CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_017030	Corallococcus coralloides DSM 2259, complete sequence	38 crisprs	DEDDh,csa3,cas3,WYL,Cas9_archaeal,2OG_CAS,DinG,RT	3	13	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_017030_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_1

190099-190195

Orphan

Consensus_repeat	Method
GGATGCGGACCGGAATCATGCGGCCCTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_1

>merge|NC_017030|1|190099-190195|CRISPRCasFinder
GGATGCGGACCGGAATCATGCGGCCCTCCTGCTGCCGGACGGGCTTCCTCGCAAGAACTCCCGCGCATGGATGCGGACCGGAATCATGCGGCCCTCC

>NC_017030|1|1|190099-190195|CRISPRCasFinder
GGATGCGGACCGGAATCATGCGGCCCTCC	TGCTGCCGGACGGGCTTCCTCGCAAGAACTCCCGCGCAT
GGATGCGGACCGGAATCATGCGGCCCTCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014393023.1\|202432_203473_-\|DUF2236-domain-containing-protein	unknown	unknown	gnl\|CDD\|378343
NC_017030.1\|WP_014393006.1\|181318_182152_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NC_017030.1\|WP_014393011.1\|186747_187896_+\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NC_017030.1\|WP_014393024.1\|203668_204682_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236947
NC_017030.1\|WP_043322503.1\|199059_201123_-\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|274618
NC_017030.1\|WP_014393007.1\|182206_182944_-\|3-keto-5-aminohexanoate-cleavage-protein	unknown	unknown	gnl\|CDD\|225785
NC_017030.1\|WP_043322498.1\|180468_181329_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|225136
NC_017030.1\|WP_014393025.1\|204683_204881_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393009.1\|183667_185935_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393021.1\|201283_202111_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|131480
NC_017030.1\|WP_014393012.1\|187892_188408_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393019.1\|198490_199048_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393004.1\|176909_180458_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014393022.1\|202145_202430_+\|DUF427-domain-containing-protein	unknown	unknown	gnl\|CDD\|377265
NC_017030.1\|WP_014393018.1\|196515_198177_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NC_017030.1\|WP_014393016.1\|192112_195310_-\|multidrug-efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|273335
NC_017030.1\|WP_014393017.1\|195319_196528_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NC_017030.1\|WP_148282157.1\|186089_186698_+\|DUF2378-family-protein	unknown	unknown	gnl\|CDD\|370550
NC_017030.1\|WP_014393013.1\|188411_189152_-\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|153249
NC_017030.1\|WP_148282458.1\|183112_183655_+\|DUF2378-family-protein	unknown	unknown	gnl\|CDD\|370550

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014393023.1\|202432_203473_-\|DUF2236-domain-containing-protein	gnl\|CDD\|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	0.00155736
NC_017030.1\|WP_014393006.1\|181318_182152_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.14746e-30
NC_017030.1\|WP_014393011.1\|186747_187896_+\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	3.68437e-09
NC_017030.1\|WP_014393024.1\|203668_204682_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	7.33134e-164
NC_017030.1\|WP_043322503.1\|199059_201123_-\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|274618	TIGR03508, decahem_SO, decaheme c-type cytochrome, DmsE family. Members of this family are small, decaheme c-type cytochromes, related DmsE of Shewanella oneidensis MR-1, which has been shown to be part of an anaerobic dimethyl sulfoxide reductase.	4.62524e-11
NC_017030.1\|WP_014393007.1\|182206_182944_-\|3-keto-5-aminohexanoate-cleavage-protein	gnl\|CDD\|225785	COG3246, COG3246, Uncharacterized conserved protein [Function unknown].	3.55755e-34
NC_017030.1\|WP_043322498.1\|180468_181329_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|225136	COG2226, UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism].	4.77644e-18
NC_017030.1\|WP_014393021.1\|201283_202111_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	1.17757e-47
NC_017030.1\|WP_014393004.1\|176909_180458_+\|AAA-family-ATPase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.73409e-60
NC_017030.1\|WP_014393022.1\|202145_202430_+\|DUF427-domain-containing-protein	gnl\|CDD\|377265	pfam04248, NTP_transf_9, Domain of unknown function (DUF427). This domain contains a beta-tent fold.	5.55792e-40
NC_017030.1\|WP_014393018.1\|196515_198177_-\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	1.18292e-38
NC_017030.1\|WP_014393016.1\|192112_195310_-\|multidrug-efflux-RND-transporter-permease-subunit	gnl\|CDD\|273335	TIGR00915, Probable_aminoglycoside_efflux_pump, The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family. Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate].	0
NC_017030.1\|WP_148282458.1\|183112_183655_+\|DUF2378-family-protein	gnl\|CDD\|370550	pfam09536, DUF2378, Protein of unknown function (DUF2378). This family consists of a set of at least 17 paralogous proteins in Myxococcus xanthus DK 1622 and and 12 in Stigmatella aurantiaca DW4/3-1. Members are about 200 amino acids in length. The function is unknown.	5.74089e-61
NC_017030.1\|WP_148282157.1\|186089_186698_+\|DUF2378-family-protein	gnl\|CDD\|370550	pfam09536, DUF2378, Protein of unknown function (DUF2378). This family consists of a set of at least 17 paralogous proteins in Myxococcus xanthus DK 1622 and and 12 in Stigmatella aurantiaca DW4/3-1. Members are about 200 amino acids in length. The function is unknown.	5.03627e-64
NC_017030.1\|WP_014393013.1\|188411_189152_-\|acyltransferase-family-protein	gnl\|CDD\|153249	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.	4.8906e-37
NC_017030.1\|WP_014393017.1\|195319_196528_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	1.27619e-66

>NC_017030.1|WP_014393013.1|188411_189152_-|acyltransferase-family-protein
MTVTATAARAAWLTTFRLLQRYHRYEVVNLEPLLRPGAKLLVGYHGRPLAVDLCMLTVTLHDRLGYLPHGIAHGAFDRIPGMRQVADGLGFVTSDGPLLAEAVKKGEHVLVQPGGTREGCRDFRHRYRVDWGERLGYLRLAVRYGLPIVPIAGHGMDDAYVGLNDGYAWGKRVGMPGRLPLWLGVGATGLWPLSLPFPVKMIQWIGEPLTTHLAPGFDAADREALLKVHREVTGAVQGLLDAARPS
>NC_017030.1|WP_014393012.1|187892_188408_+|hypothetical-protein
MSRYVVDTDVLANVQRAGHALTLRELGTLPVVITDTVWDELTVGASLAGAPERLVQEAEAMLKAIAGAPTVLVPQSLEAQTLVQLQLPPVTEGMGEHSVIAYACHHPDATAILHDRRALHRGIEELRGRVLSLHGFLDVLRREYGLAPKAAHQISEWYCVRNKPQRRPLWW
>NC_017030.1|WP_014393011.1|186747_187896_+|ImmA/IrrE-family-metallo-endopeptidase
MTQGPPTDDASDALRELGRRLSRRRKEAGLEVEALASRARVSAHLIRTFEQGEQALGLSALTRLASALGLAPTAFFHTSAPVEQVPLEPAALLKGSAVSASLSDTDRTFLLEGLRQARAFSLLGALRQVPRLADQFHPEPPPMRNAHQAGYACARRVRALLPERQGPLRNLGRLMESHFDVLVLRHAFTNPAVHGVSCRSGNARLIVIHSELTREPVRRFVLAHELAHQLLDLSESDVQTDEGRLDSSRFWMENPPAEKRANAFAAMLLAPEEAVTQSLGAAKPEGYGLKEARELVIRARTHFGLSFSAMAWHLYNLRYIRERETVEALLMASDETVLEGFEDDTRFTGIERRALDAHAHELISSSRARELLGRPVEDLLAT
>NC_017030.1|WP_148282157.1|186089_186698_+|DUF2378-family-protein
MFELTRGHPSHVIPRDVAEEPLVSNPSEIIFGHTVEGLLLALKGRLDGPLRAKLKDAGLDLDRKLEPAYPNAIWQKVLHLCATELFPGVSMNEAQWQLGERFVAGYFETNMGRALQAVVKLLGPARTLERTSRNLASGSNFLHVEVERLAATDYRIKVNEGGTYPEFIGSICHHGTLTTGVKGLTTVVESRQGRAAIYRMRW
>NC_017030.1|WP_014393009.1|183667_185935_-|hypothetical-protein
MSWSIHIPAVNTLKLALGNAAHEQALGHAELNGNKAIPIQGGAVSLTGTLKVPVELFNDRNDKDAYGIIGVPPKTLDGSSVEPLFSPDGAACWLKYAAELSAEANGQGHFPFVELSGGGALQVKVADYRHHAATQTLEAALGSDVKSLRLPFVLGDVQALQPGDALSFQTCVALKAGVKVSWSAISTSLVAALAKRLAGQLVFELKAEAGASIGGTVSLQDEFRIVFSRPKDGGPFRVSVRKATSDAAAVHVSAGVSLEYSSPLLASILSAVDAKVQDALKLVEGLEQGSLQPALLQVAAALLKQLGFLKSVEPTVSAVTAAYEELKDFVESVVSGSLKAGFEYEYARSTEDATLLELEVPVEELAGAHGAFVSGDLASIQRRVNDTWLRRYFHMKSVESQRVWGLGLGWRDVNFASQEDRRKLKAVVQHASRDHRQGPRRYAFLGARSYTSSGVLYGKTSRWGLDFSAQMPRFSLTPSADEFEYSFFAQSQVEDGLSKELIQRAVDGATVWGAVRPEDAPALVDRLFRAAPAGTKTVTRLDLRVDNPSFRRLLAKLGSEPAFERNAFARALARALPRASQPVRTSLQRREELYTPLWDAYLKDGAKDWTLDRARASVAWHLKTQAGADGFVASHWEQTGGTGTFSDVLVQSSRYGGDIGSQPYGKVYVFWRDLLDKLIALNKAIHSEAVIAENDSTSAVQQVFTALDDLACDDFRVTAFVAWMDQLAIRWKLGSGIQRLLQVRVGEQEFVISHG
>NC_017030.1|WP_148282458.1|183112_183655_+|DUF2378-family-protein
MRPPEKVVFGHTVEGLLVTLDGHLEGPLRPRLKAVGLDLDQKLAPAYPRDQWHQMLLLGAQVLFPHHSVAQAHWHLGQRFVTAYFSTRIGRALQGVLKFLGPARTLERTTRNMASGNNYLHVDVERLAATDYRLRVNEGGLHPEFIGALCHFGTLTTGVKGLTTVVEGREGPAATYRMRW
>NC_017030.1|WP_014393007.1|182206_182944_-|3-keto-5-aminohexanoate-cleavage-protein
MLLKVCLNGARAAADHPRLPILPEALARDAAACHGAGAGAFHVHPRAAHGGESLDAADIGVAVSAIRHACPGVPVGVSTGAWILPDVKARHARIASWKALSAGTRPDFASVNLSEPGWDAIADALLDAGIGVEAGVWFPEDVPRLMAWPRAPECLRVLVETQSSQPEAACQEARTLVDLLRATGLSRPLLVHGSEGGAWAVLGWARRHGFDTRIGLEDTLVLPDGQRAEDNAALVAEAVRPLRGQ
>NC_017030.1|WP_014393006.1|181318_182152_-|SDR-family-oxidoreductase
MHEPPAAGGSSPAWALILGASSGSGAAIAEAVARKPGLNVFGVHRGRYPDTARELEARVRDAGRDVHLRQADASTPEAAEAGADELLQRAGPRSVKLFVHAIAGASVGHFLSEGPDRLHPRRIQRTFDCMAHSFVYWTQALVQRDLLAPDARLLGLQNPLDETHLGNTGLISAAKASLEMYVRHLAMELGPKGHRVNLLKFGTVMTPALRHVYSPEALARLEARHAAMNPAGRMGTLEEVARFVTVLVGDDAAWFNGATIDFTGGMTLKLLDLVLNP
>NC_017030.1|WP_043322498.1|180468_181329_+|methyltransferase-domain-containing-protein
MWLRDVALLACPDCRGQLVWHGQSEDDRLDEGRLLCGGCGETWKVEDGLARLYREDRVQGTDRLMRHIYDGLPALHDPLTAVLTPLFQSVSESRMRDGYMRRLELGALKPRDDGQPVRVLEVGVGAGANLPRIRGALPPGLPVEVWGLDLSTGMLAQCEKRLRKGRGVKDTRLLVADAHALPFKDGLFDRVFHVGGIGSYRQPAVALREMARVARPGTPLVVVDEQLDAAFRPSLFQRAAFRALTFYTRDAKSPRDLLPRNAEDVIEEQVSPFYYCLTFRVPAVTG
>NC_017030.1|WP_014393004.1|176909_180458_+|AAA-family-ATPase
MSHPPSCQTSPRADAPDADTSPGMDPEVVGRRYRILDLLGRGGAGTVWRAQDGLSGPVALKRLHKTVADLARRPGRGTPSAFATQGMALSLAHEFQTLVSLRHPHVIRVLDYGFDAEGRPYLAMDLLEDARTLVEAGTDAPLTVQVGLLIQTLQALAYLHRRGIIHRDLKPGNVLVVRGQVKVLDFGLAVGRDQQGRRAQPAGTPGYLAPELFEDQPPSELTDLFGFGAMACQMFFGRLPHAGQVFATPGFPPALKALLEQLVAPEAHRRPRDAEAVITALCDAVGQPRPAESAATRESFLQSARFVGRVAEREHLTDVLDAALAGQGGAWLISGESGVGKSRLLEEVRSLALVRGAMVLRGQAVDTGGVPYQEWRAVLRWLPMLTELSDREARVLRPLVPDLEALLDRQVPAAPELDADMAQLRLHQTVEDLFARLSQPTVVILEDLHQAHAESLQLLAQLAARAPGLPLLLLVSFRDDESPQLPEHLPGTRVLRLQRLNAEEIAQLGESMLGAVGRRPDVVELLRRESEGNPFLLVEVVRALAEDAGGLDRLGAVALPQRVWAGGMRALVQRRLEKVPREARELLDVAALLGRELDLAVLERAAPGVDVEAWLTDCAAAAVLDVADGRWRFAHDKLRERLLEDLSPAIRPVLHRRAALALEAAHPTGHAAALSYHWGQAGDAARESHHARLAGEEALAVGACREALPLLSRALAVAPQATPLERGRVEALLAEARFQLGDLEAFRAHAEAALAHFGWRVPSSRVAWVLGTLTQALARLAQSARPDAYVDDSRRRRETRRVAGRLLMRLTDAFIYAQEALPVLWSGLRMLNLCEPAGPTPELARGYTVMAVVAGTVPVHRVADAWVKRAQEVAESVGRPADLAYVLNRNAVCAVYQARWQDVETWLSRATAIVDSVGDLRLAEECRALLTVSAMYRGQFARGLPLMDWLEASAVRRGSAQTQHWAQHYRAHMLLRLGEHARARVALEPALAWTEAHGGATDRIITDGTLALLCLREGDAAGARAAAEKALVRLSAGKPVAHFVYFGATAVAEVLLTLWARETPGPGLQALTHSARAALQAVEGFARVFPFGEPAAWLWRGCEAWLAGKHRKAFRAWKRCIAESDARGMPYEAARARLEWARHLPADDAERAGLLRRAAEDFTRLGAREDLARTLAEQGTAG
>NC_017030.1|WP_014393016.1|192112_195310_-|multidrug-efflux-RND-transporter-permease-subunit
MFTDFFIQRPVFSSVLSILITLVGAISIPSLPIEQYPELALPQVQITATYTGASAETVESAVTTVLERQLNGMEGMRYMSSTSTNDGQSTITATFDPSRDVDLAAVDVQNRVATATPQLPAQVNALGVTVRKAQTQLLVSFGVFDKEKRYDTEFISNYADVFIRDALLRVKGVGDVRIFGERRFAMRLWLDPTELARRSLTAQDVVNALQEQNVQVGAGKVGQAPSSKEQAYQLSLQVKGQLTSADEFGAIVIQRGADGALVRIRDVGNVQLGAENYQQLLRFNGQDAVGLGITQLPGSNALEVREGVEAELQRLSANFPPGLTYQVAFDTTAAVSASIEEVLQALGEAILLVILVIFIFLHGWRSVLVAVTTLPVSLVGTFMFVNAFGFSLNTLTLFGLTLATGLVVDDAIVVIENVERVIEHEKVDAKEATHRGMQQVAGVVVATALVLSAVFIPVSFFPGTTGAIYRQFALTIAFSISLSALVALTLSPALCARLLRPNEGQKFVLARKFDQGMDALRRGYGKLLRLMLGKLRWVVVGIFAVFLVATGLLYRATPTGFIPDEDQGYVIIAVQGPEGTSLEYTRNVLIQVEDIIKQQEEVTQIFTVGGFSLLGTGANYGSLFINLKPWEERKAKESSVAGLIERLRGPLGQVGGARVLPLQPPAIRGVGSVGGFEFVLEDQQGGRTLEELAQATQALVGKASQDQRLRGVFSAFTAGSPQLNIDVDREKAKAMGVPLSSLFSTLQVYLGSQYVNDFTFANRVYRVFVQAATPFRDNPKDIGSFYVRSDTGAMVPLEALVKVTPITSAQNITHYNLFRSANINGQGSPGTSTGTALNAMEEVAKQALPPGFTFEWTGLSQEQKSAGNTVLIIFALGIVFVFLVLAAQYESFALPFVVMLAVPVAMMGALLLQNLRGLVNDVFCQVGLVMLVGLASKNAILIVEFGEQLRAQGQGVVESAINAAETRLRPILMTSFAFLFGVVPLMLASGAGASARKSLGTAVFGGMLFSTFVNLIFIPVLYALVEGARTKILKHRKHGNSPSGPQNPPPPSIPPEGEPPRPQPA
>NC_017030.1|WP_014393017.1|195319_196528_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MRVVRGGWGAWGLVLALTAGGCSGGKDPGQAAPGGGPQGGQQSQGGGKPTPVQVMAVKPGPVRDTREYVGTLISRSSITVVPQVAGYIQKIPVRQGQKVKAGQVLLVVDPRQEQASLRATQAQKASAVANREFARRTRERSAQLLKEGLVSRQDYEQAVAQAAQSEAQAQAAEAQIQNQQVQLGFFNVSAPFDGVVGDIPVKLGDYVTPQTALTILDQSRALELSVQVPVDQAARVKIGETPLEILNEDGEPIVRAPAFFVATTPNPNTQLVEVQAAFENTVGLRAGQLVRAQLVYDVRDALKMPTTAVTRQGSQSFAMVVGEGDAGTVVKRQPVTLGLVEGNDYEVLKGLDAGTQVIISGVQQLRDGMPIQPKPARQSQGQTEGMPLPPAQGMGGGADAGR
>NC_017030.1|WP_014393018.1|196515_198177_-|TolC-family-protein
MNAFVFAALLVPSGIPGEAPAPHGSGPSRPLVAQYTAPPQRAPPAPPPPTPPVTPPNTLAPNAPAPNAPVLKLPEQPPAAPNAPAPNTPARTPARQPDRTRTPSSQNPDDVPEVPPPFQANVSDPLLTPAPAAPQEIQSWNEALTLLRQRSTDLQAVLGQVEVAAGTWRIALANLLPTVGGTLSAQYNILNPNIPAVGGGIGGGVGGGVSGEGGFTPTELLGIGVLNANVPVVDLASLYALGSAKESRRTAALSLAETRRQLTRGLAQALVSVSSNERLAEVNRVNLRTALERLALAQRRFELGAGTRLDVVRVEQDAQTARRNVVTGDENLRQAREALGLALGTPSAVGIKPGLELTTLFEGTKATCRTLESLENRPDIAAAKSRQVVAERAIGEVYRQYAPTLDLTSTTTALTVNPGFAEVPIWNVGASLVLPFWDGGAREGRLRQARGQLEQARADVTNRERNIVIEVTQAKRAVQVTQATRDLAERERRLAEENDRLTRRSFEVGTGTSLELVDAAGALRQAELELVIRDFQFRQAQVDAFLSEAACEW
>NC_017030.1|WP_014393019.1|198490_199048_-|hypothetical-protein
MSVAWRALPAALLLAGCLRSTPTRDAWTNDTSIEFPRFFEQPAVEAGVDGSTVELSGSVLRALEVAAADFLGPQDANTPCVDRRESHRYRVVQRQGVIFIRIDEDPRACGLTVPALHSGAQYAVGSDGRLLRRLRDGEPDESRVPTDAGPGTLVPTSEVGRSFDPPDGSMPLPFPDAGTGARQGP
>NC_017030.1|WP_043322503.1|199059_201123_-|HEAT-repeat-domain-containing-protein
MRSSRPVLVALAVVVLAAGLFFFLRPSAPTPAVSPPVTQAPAPAPETPLDAGSVAAPVPVKTVEAPPSKPNHFVGSQVCADCHEEQHTGWKHDWHSRALSPATKPYVVGTFAAGTHFKGESSEAWMRRDGSQYLMRTKGADGNLGEWPVQWVVGGKRMQDPITLLPDGRWQVMPVYFHVTGKGEWVDYSEKKQGALSPDHPFFWTNFRRSAQHACLDCHVTGLDARYDRASHQWETKFADAGVACESCHGPGGRHAESQVPADIIQPAKLSKEEGFAVCAQCHGPRRTLFPMLDAKHHFQPGQRYDASYQPMVMLVGNDRSGDFFADGRPSTSSFEYQALIQSQCHLKGGATCLTCHTAPHDASAPNEVRKQKPVAARTSVNASTCQGCHPEVVAQGEQHTHHKAAAAQDCLACHMPPVVSGVLDHFADHALDVPAPRNTARHDIPNACNTCHAKQTPDAMQASLVKWWPKAEARQARRLRLADAFDEKTAALSRGALEAVLADTTEAGTLRGAAAKFLARRFKRDAVPALRAALKGTTDSTLRSDIIDGLGAANAREATEDLAALLKDGSLWVRQGAALTLAAFGDARAMPALQALATEPETRGLVQPHVMLGQLAMRRRDVTTATREFEQALDLQPYNADVLVRLADLYVVQGNPAKGRERLEEALRFDPQNKSAKQRLGMLPAQ
>NC_017030.1|WP_014393021.1|201283_202111_+|alpha/beta-fold-hydrolase
MPMRSVNGTRLYYEDTGGSGDVVLFSHGLLWSTRLFDPQVEALRGRFRCIAYDHRGQGQSDVSPESSIDVETVYADAVALIESLGVAPVHFVGLSMGGFVGMRLAARRPDLLRSLVLLETSADPEPTANVPRYTALNLIARYVGLAPVATAVMRIMFGASFLTDPGRAEERALWRTRLTGNRRDIYRAVNGVIKRKAIAEELPRIRTPTLVIVGEEDRATVPAKSERIHSLIPGSQLVRLSRGGHSSSVEEPALVNAELAPFLTQHASNRAAHAG
>NC_017030.1|WP_014393022.1|202145_202430_+|DUF427-domain-containing-protein
MPVAKWNGTVLAKSDTYETVEGNIYFPPDSLVREHFKPSATHTTCPWKGEASYYSVEVDGKTNADAAWYYPEPKPAASNIQGHVAFWKGVTVER
>NC_017030.1|WP_014393023.1|202432_203473_-|DUF2236-domain-containing-protein
MPFTFRGQNLDAILGDALDAPNSLFGIMSAADPQFMQGLRQHWTKHAQATPSVNGWKPALKAFSDIAADWWNTYSDHRLAGILYGAQAHATATAAVTGAQSSAQFLRDFEAARDEAFYVFFQATSVNELAGVSFQATYYHYDVSALFEQRPHSKLKAIVSRRVIETAQIMLRILYGNMSMGWGSLYSTRTLATTLLLAQMHNVALQHYRSRYTDRRCYNQSAVAFTLLTFSYVVAQAWRDKRYEFNEQRWYYFWKLLGSLLGVDTRLIANTHAEAAELWDLFFEHHECQGGPGAPYPTTLDPRRIHSELRAGYDVQPEANLLQWVPAFIVTQMRNSLRWGKYLLGR
>NC_017030.1|WP_014393024.1|203668_204682_+|ABC-transporter-ATP-binding-protein
MATVSLQDVRKVYRGGVAAVKGVTLDIADGEFVSLVGPSGCGKSTTLNLIAGLEELSGGELRIDGQLVNDLSPRERDIAMVFQSYALYPHLDVAGNLAFPLKVAGMDAKDVEARVREVSGVLGLEALLARRPKELSGGQRQRVALGRALVRRPKVFLFDEPLSNLDAALRTQMRGEIKKLHEQLKATFIYVTHDQAEAMTLSDRVVVMSQGEVQQVAPPRELYDAPANLFVAGFFGSPRINLVKPQTLGLPDGDAVLGLRPEHLQVGQGARPEDAREGRVYLVEPMGAEVWVTVEMGGERLVARAPGDFRAASGDTVWLRHDARYLRRFDARTGRAA
>NC_017030.1|WP_014393025.1|204683_204881_-|hypothetical-protein
MLLELSNDESRVLKDAVDSSLQMLLAEIAQADQRELKEALHQRYDRLVALQRRLEPVVESEQVYA

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Crispr_ID: NC_017030_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_2

859639-860354

Orphan

Consensus_repeat	Method
GACAGTCGGACAGGTTTNGGAGNACCG	CRT

10 spacers

The CRISPR arrays of NC_017030_2

>merge|NC_017030|2|859639-860354|CRT
GACAGTCGGACAGGCTTGGACTGAAAGGCCGTGCCCGGGCCCCCGCTCAGGCCGCGCGGCGGAAACCTGTCCGACAGTCGGACAGGTTTGGGAGGACAGTGGTCGGAGCCTCCGCTCCATCCAGGCGGCGGGAGCTTGTCGGTCAGTCGGACAGGTTTTGGAGAACCGCGGCCGGAGAACCTCCTCCCCATGCGGGCGGAAGAACGTGTCCGACAGTCGGACAGGTTTCAAGGAACCACGGTCGAGGGCCTCGACTCCATCCATCCAGGGGGCGGAAACCTGTCCGACAGTCGGACAAGTTGGGGAGGACAATGACCGGAGACCTCTGCTCCATCGAGCAGCGGAAACCTGTCGGACAGTCGGACAGGTTTTGGAGAACCGTGACCGGAGCCCCGCCTCAACTGAGCAGCGGAAACCTGTCGGACAGTCGGACAGGTTCTGGAGAACCGTTGCCGAGGGCCCGCCTCGGCTGCGCGGCGAAAAGCTGTCGGACAGTCGGACAGGTTTTGGAGAACCGTGACCGGAGCCCCGCCTCAACTGAGCAGCGGAAACCTGTCGGACAGTCGGACAGGTTCTGGAGAACCGTTGCCGAGGGCGCCGCTCCAGCGGGACGGCGGAAACCTGTCGGACAGGTTTGGGAGGACCGTGGCCGGAGCGCCTCCGACCCATCCGGGCGGATGAACTTGTCCGACAGTCGGACAGGTTTTGAGGAACCG

>NC_017030|2|1|859639-860354|CRT
GACAGTCGGACAGGCTTGGACTGAAAG	GCCGTGCCCGGGCCCCCGCTCAGGCCGCGCGGCGGAAACCTGTCC
GACAGTCGGACAGGTTTGGGAGGACAG	TGGTCGGAGCCTCCGCTCCATCCAGGCGGCGGGAGCTTGTCG
GTCAGTCGGACAGGTTTTGGAGAACCG	CGGCCGGAGAACCTCCTCCCCATGCGGGCGGAAGAACGTGTCC
GACAGTCGGACAGGTTTCAAGGAACCA	CGGTCGAGGGCCTCGACTCCATCCATCCAGGGGGCGGAAACCTGTCC
GACAGTCGGACAAGTTGGGGAGGACAA	TGACCGGAGACCTCTGCTCCATCGAGCAGCGGAAACCTGTCG
GACAGTCGGACAGGTTTTGGAGAACCG	TGACCGGAGCCCCGCCTCAACTGAGCAGCGGAAACCTGTCG
GACAGTCGGACAGGTTCTGGAGAACCG	TTGCCGAGGGCCCGCCTCGGCTGCGCGGCGAAAAGCTGTCG
GACAGTCGGACAGGTTTTGGAGAACCG	TGACCGGAGCCCCGCCTCAACTGAGCAGCGGAAACCTGTCG
GACAGTCGGACAGGTTCTGGAGAACCG	TTGCCGAGGGCGCCGCTCCAGCGGGACGGCGGAA
ACCTGTCGGACAGGTTTGGGAGGACCG	TGGCCGGAGCGCCTCCGACCCATCCGGGCGGATGAACTTGTCC
GACAGTCGGACAGGTTTTGAGGAACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014393575.1\|856138_857074_-\|transcriptional-regulator-GcvA	unknown	unknown	gnl\|CDD\|182990
NC_017030.1\|WP_014393584.1\|866083_868702_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_017030.1\|WP_014393573.1\|853797_854784_-\|zinc-dependent-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176645
NC_017030.1\|WP_014393581.1\|863210_864317_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393572.1\|852999_853764_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|187600
NC_017030.1\|WP_014393571.1\|850413_852963_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370664
NC_017030.1\|WP_014393577.1\|857479_858262_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NC_017030.1\|WP_014393579.1\|860391_862557_-\|molybdopterin-oxidoreductase-family-protein	unknown	unknown	gnl\|CDD\|239163
NC_017030.1\|WP_043320998.1\|871168_871675_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_148282182.1\|862621_863134_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393586.1\|869606_870173_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393578.1\|858306_859287_+\|homocysteine-S-methyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224951
NC_017030.1\|WP_014393585.1\|868706_869600_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_193352549.1\|864570_865119_+\|chalcone-isomerase-family-protein	unknown	unknown	gnl\|CDD\|374318
NC_017030.1\|WP_014393587.1\|870191_870641_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_193352525.1\|854990_856142_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103
NC_017030.1\|WP_014393583.1\|865240_866053_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|181619
NC_017030.1\|WP_014393576.1\|857188_857470_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393569.1\|848001_848733_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NC_017030.1\|WP_014393570.1\|848810_850241_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014393575.1\|856138_857074_-\|transcriptional-regulator-GcvA	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	7.78717e-117
NC_017030.1\|WP_014393584.1\|866083_868702_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.61129e-37
NC_017030.1\|WP_014393573.1\|853797_854784_-\|zinc-dependent-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176645	cd05282, ETR_like, 2-enoyl thioester reductase-like. 2-enoyl thioester reductase (ETR) catalyzes the NADPH-dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the alcohol dehydrogenases in this family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. Candida tropicalis enoyl thioester reductase (Etr1p) catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis. Etr1p forms homodimers with each subunit containing a nucleotide-binding Rossmann fold domain and a catalytic domain.	5.94192e-134
NC_017030.1\|WP_014393572.1\|852999_853764_-\|glucose-1-dehydrogenase	gnl\|CDD\|187600	cd05341, 3beta-17beta-HSD_like_SDR_c, 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. This subgroup includes members identified as 3beta17beta hydroxysteroid dehydrogenase, 20beta hydroxysteroid dehydrogenase, and R-alcohol dehydrogenase. These proteins exhibit the canonical active site tetrad and glycine rich NAD(P)-binding motif of the classical SDRs. 17beta-dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens, and include members of the SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	4.72525e-109
NC_017030.1\|WP_014393571.1\|850413_852963_+\|hypothetical-protein	gnl\|CDD\|370664	pfam09756, DDRGK, DDRGK domain. This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.	7.65712e-05
NC_017030.1\|WP_014393577.1\|857479_858262_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.89026e-64
NC_017030.1\|WP_014393579.1\|860391_862557_-\|molybdopterin-oxidoreductase-family-protein	gnl\|CDD\|239163	cd02762, MopB_1, The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NC_017030.1\|WP_014393578.1\|858306_859287_+\|homocysteine-S-methyltransferase-family-protein	gnl\|CDD\|224951	COG2040, MHT1, Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism].	3.87938e-37
NC_017030.1\|WP_193352549.1\|864570_865119_+\|chalcone-isomerase-family-protein	gnl\|CDD\|374318	pfam16036, Chalcone_3, Chalcone isomerase-like. Chalcone_3 is a family of largely bacterial members.	9.53293e-31
NC_017030.1\|WP_193352525.1\|854990_856142_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	1.73266e-12
NC_017030.1\|WP_014393583.1\|865240_866053_+\|OmpA-family-protein	gnl\|CDD\|181619	PRK09039, PRK09039, peptidoglycan -binding protein.	3.24648e-41
NC_017030.1\|WP_014393569.1\|848001_848733_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	5.6157e-47

>NC_017030.1|WP_014393578.1|858306_859287_+|homocysteine-S-methyltransferase-family-protein
MSGLANHASFLRALHEAPRVLTEGSVVERLRRHPAGLLDPHVANAGLLFNPEGREALAGIYRDYRDIGLRHGLPTLLLTPTWRANAERLARAGLAGRDVFGEAVGLLAGLRDEVGGRGEGVFIGGLVGCRGDAYRPEEALPREEAAAFHAPHVEALARAGVDFLVAQALPALSEAEGLALAMAGTRAPFLLSFILRPTGTLLDGTPLAEAVARIDALPGARPAAYMVNCVHPSIFREGLSRQLAASPALGARVVGLQANTSRLSPEELEGRAELDSETPDAFAREMARVHAECGTRLLGGCCGTDERHIAALASALTEGAPGERRP
>NC_017030.1|WP_014393577.1|857479_858262_+|SDR-family-oxidoreductase
MSARFPHQKLIVVGGTSGMGKAVAQLVLEEGGRAVVIGHRDDKLQAAVTELAAFGSVDGLRADITSGAERQALVAQLRRDHADATLLVNAAGVFLPKSFLEHEERDYDLYLDLNKAVFFITQAVARSMVAMGKGGAIVNIGSMWARQAIQATPSSAYSMAKAGLHSLTQHLAMELASHGIRVNAVSPAVVETPIYEGFIPKEQVHRTLQGFNGFHPLGRVGRAEEVARTIAHLLSNEASWVTGAIWDVDGGVMAGRNQYS
>NC_017030.1|WP_014393576.1|857188_857470_+|hypothetical-protein
MVYLQITLRISPNNRPAAAGVYQRYKAPFLETIAGAKSKELLVRDEDVQVLHGFETAQQASAYLKTDLFNADVVAALKPLLDAAPDVRIYQAA
>NC_017030.1|WP_014393575.1|856138_857074_-|transcriptional-regulator-GcvA
MSAPEHLNALRAFEASARHESFSAAAAELHVTPAAVGQLVRSLEEALGTPLFHRGTSGRKRLVLTEAAQRALPDIRAGFERLSVGVARLKESSSAGVLTVTVSPAFAAKWLLPRLERFQAAWPELDVRLDASTELLDFAARGVDVGVRYGAGSWPGLVAEKLLGEEVYPVCSPALLRQNRRPRRPSDLRGLRLIHDRSVDARLGFATWDAWLEKAGAKDVETKRGLRINNSASVLQAAIDGQGVALARSIMAHDDLAAGRLVRLFPEVEFPSVLAYYVVYRPECATLPKLVAFRDWLVREASARQALTDRT
>NC_017030.1|WP_193352525.1|854990_856142_+|flippase-like-domain-containing-protein
MTVGAAQVLKWTPRWGGWGRARRSSVSNVHHEGALAGPGAAAGEGLSASPCVWRRRLLTVLKPVFAMGGLGMLGALVHKAGAGELKTTLLEALPLLPWVVFIEMGRQACDATATRLSYGARARQVPLSVLVRAQLIGTAVSSMAPAGRAAAEATKATLLTPYTGGASATAAAATSQSASLGAGGLISFPCALAAYLMTGWSAFTVAMLVHGVVLLLASLGVRAGLRAKRLGAWMRRRCGKWGEHAEAFQASVCAGGLCPWRPMMAFLGSRVLQVMQYAVLAHAVGIDTTLVQALFTQGLYLVALAMGSLVPGQVGVTDGMFSLAAGAMGTTAAKAMSIALLAHTVQAVFVLVGALTPLVWRAKAKVAAAAPVVPPVLPAPVYR
>NC_017030.1|WP_014393573.1|853797_854784_-|zinc-dependent-alcohol-dehydrogenase-family-protein
MKAVRFSAFGPPSDVVQVVEDSPAPLKPGEARLAVLATPINPSDLLTLSGEYGVLPKLPATPGNEGVGRVVEVSGTESVAVGDLVFLPLGAGTWRTHLTAPAAQLLPVPPGLDLLQASMLLINPPTAYLMLRQFVTLQPGEWVVQDAANSAVGRYLITLAQVMGLKTVNVVRRQELADQLKAQGADVVLLDTDELPQQVRAATGGAKVRLGIDAVGGESARRVGDCLSTGGTLVNYGSMSGKGPKLSAAATIFKDVTLRGFWLTRWLRDAPREEQNATLARLAELMAVGTLQAPVDGTYPLERIQDAVKRALEPGRNGKILLTPNPAA
>NC_017030.1|WP_014393572.1|852999_853764_-|glucose-1-dehydrogenase
MKRVEGKVALVTGGAGGLGAASARMLAREGAKVVVTDRREDEARAVVEELGDAGLFLPLDVTREDQWVSALARTVEKFGRLDVLVNNAGTGVVKDVEELSLDEWKGVHSVNLDGVFLGCKHGIRVMKECGSKGSIINISSIAGLVGVPQYPAYCSSKAAVRMLSKSVALHCAYKGYGIRCNSIHPGYVETAMVEALAQAGGHAEKTRARMLKGIPAGRFGEPDDVAHAVVYLASDESKLMTGAEMVLDGGATAQ
>NC_017030.1|WP_014393571.1|850413_852963_+|hypothetical-protein
MSALLDSGVRQGAEVRCPGCIRFIPADAACPHCLCGAIPPERHGSARALVKSGVDRFALAARTAALEPAQVAVLEARYARQWGAVQRLAEDARRIEPLLIQRGFVRELEDSWALILPIEDAALEEMLAPFSPMPDSVEWLANKSPDPTLRLLGALACVHQGSGSRDARFAVSNQVLHGEGRVAVEAMLAMTRWRNGLDPRLSPEERERIRTLALGVLHVPELSARAAVAWTRASHEPTPANVTEALHRGLYGSDPDVRFECALCLRDEMEVSQALDSSDADLAAFARRVLSQWGSRRLLARLQKDGDAAFAKEVLRELPTPPPEGALEALLTVSLRTVGSLADELLSFAKRRPFREWGLEDQRRWARWARSVLSDLPAETALDFFSWAATPPRDDPEPPEEEESEAMWAFLEETVHAIDRGTTKDRTACFGESEFARFLHHSGVDEQRRLNDWACDMYSGEALLEALILFPSRARHLGLVPDISRTEKHPDPGHFGRLLMAIWEGPGQHLLVAPLSRVVRSWRSLTGSELFVEAVWRRFQSHPAERAALLTAFAAWRDRLWEHQCEVEPDALVRFQTWWRVDPEGLYRQTEQLLDRVPVEALPKRLRALWDAAEEVVGTRPRTASLSVSKGAMALRNGLESRDASARDVLDAELEHFESWLPAFEERVRATPSPQEESNIHRDFLDDTHNALRMMRERRERRREDEERERQRAIDRQVAESRRRDQERQLEAQRREAEALRARQAAEREQQETLSRVNAQRLLVTLQPRVALKDVDREVLFPESAFPTLVDYARMIKAMQQGADVMKLFETLGLTPATWAAQATAWGQVMVGRMDLGMRFGELLTAPWE
>NC_017030.1|WP_014393570.1|848810_850241_-|hypothetical-protein
MHRRSRSLAVLAVLLAGGTAHAESSGYCERVSKKPETKDGYEVVTIDANSGQVVDGTTRLSEDARVQFIFSGKNPFRYEYRFPVTSQPLGAAVALRFLQMIPGLDLGNLPPATAKAKDLKGLVSSQCKTPEDLKWVNEVDKRARALQQRSVQVRDNLGYFEEANSFLKVTETDVLQDLPLICGRAEKLRAWPHSPGSFTNDTDTFKTQSAALATFLGKDEGLDGKPLSTGCQAETQKATATFEDEADAYQKAAAKVEAELQTHKVAIQQLDSVLASTLTREDPFFETRYTSPRDEPTGVRAESFRRDLRTENAPERLVGTVNMELGRSPFSLSAGIVFSTIESRRLVRQPSRVPTEDNPNQVGLRFGYDEDSDVTFAPAVFFNARLSDSPRYNWGASAGIVTAAADSTLRIDYALGLFASFRDVFYLHLGLQAGQRSSLAGGFKEGEEVPADLPDPIPTTKDWKVGFLLGFSLQLN
>NC_017030.1|WP_014393569.1|848001_848733_-|SDR-family-oxidoreductase
MGALDGKIAVVTGGSTGIGFAIAERFASEGAEVVIAGRRQQRLEDAAARIGRGARGVVTDVGDDAQVKRLIDSVPRVDLLVTCAGGAVFGAVDSVPSQSWRALFNDRFFGQLSACHYAVPKMAPGSAIILCSGIAGHTALVNYSGGAGLCGAVNAMGRSLSVELAPKGIRVNVLSPGLTRDTAIDWGVPQEQVGAFLDALVSKVPLKKPGTVRDMADAAYFLATCAYATGQVIDIDGGWTAGA
>NC_017030.1|WP_014393579.1|860391_862557_-|molybdopterin-oxidoreductase-family-protein
MSASVHFRTCNLCEAMCGVRIEVADGRITSIKGDSEDPFSRGHICPKAVALRDLHEDPDRLRHPMKRTASGWERVSWEDAFRDISHRLHSIQKEHGPNAVGAYLGNPNVHNLGAMMFGPQLLRALRTRNRFSATSVDQLPHQLAAHLMFGHQLLVPIPDIDRTRYMLMLGANPLASNGSLMTTPDVRARLRAIQERGGKVVVIDPRRTETAGIADQHVFVRPGTDALALFSLLHVVLEGNAHRMGRLAAFVDGLDTVLPLVRDFPPERTAPHTGIAPDVLRGIARDFLAADGAVCYGRVGVSTQPFGSLCQWLINVLNIVTGNLDREGGALFTLPAFDLIGGPRAFGVSPGSHGRWKSRVRGLPESSGELPVAALAEEILTPGEGRIRALITLAGNPVLSTPNGTQLDTALEQLDFMVSVDPYLNETTRHAHYILPPASLLERGHYDLVFHVLAVRNTAKYSPPVFPAGPDSRQDWEILLELQHRLKTLRKGRSVRAVLKYQALKRMGPERILDLGLRMGPYGSRFHPLKKHGLSLAKLRAAPHGIDLGPMKPSLPGRLRNRSKRIQLAPELLVADVARLRAAFPDDAAPREGELLLIGRRHLRDNNSWMHNVPGLVKGRPRCTLMVHPDDASRIGLADGANATIRSRVGEVTVPVAVTADVMPGVVSLPHGYGHQRPGIRQQVASAHAGASINDLTDDQALDVVSGNAAFSGTPVQVRPA
>NC_017030.1|WP_148282182.1|862621_863134_+|hypothetical-protein
MAFLNVSVHDAEVAGVRMDSARELLQLELVLHSCEKVRVDFSSACQWSLSRFERQNVLLAIHEWKASNVATAARCRDLGLDEFWTRMVLTDRYTLYEVSASVGFGGWVLAQGAEVIRAAPETAFSPAPDVVDLLEGIRKRPGMYVRGDASQRVLQLRNLECVGAVLEARG
>NC_017030.1|WP_014393581.1|863210_864317_-|hypothetical-protein
MDLARGFRGLLAWGVVVLMGCAGANYEGVGRRCPSCTVEPMPTSLPPGTFVEYRIDTPYLTDLRATFTVLRETQTERWVEVRMRREARPEELLKGLYDRPLIFVMQLQPLPGGPSNPPFQTRFATDEERFVGPERLHRSVTSTPMKLQVKGKTFECEDHAYQMEPPRSGRGCIRAKDPRVLFAGGVFFLEEHYGDARWPSLRIRLLDMGQREVDASAGAIAVRSGQSATYVRSDGLSVTHTWTTGPTRVRHVQTYLSQDMPLPGNDFDWEGTLLEVVTALADKSGWRYRPLPDSDARTDVQVNGEALRVFHRRLSDRNGGDEPYDITHSYLEDVWQMKDAPIWIRLWPLTAQGNIGQRPVHHWLKEWK
>NC_017030.1|WP_193352549.1|864570_865119_+|chalcone-isomerase-family-protein
MGTAWTKGARGVALGMLLLLGAAAHAGQAGGVNMPDSLQVEGKTLALTHMELKKKLFFNVYVWSLYMEEEPTCFKEAVASNSLKRLHFRFLRTITKDQLVGSFREGLRQNPAMRQDALNQSLEKLLSSLHDVRKGDDLVLTYLPGSGLHVSGGASGGVHIPGKSFADALFSSWLDTHPIFPK
>NC_017030.1|WP_014393583.1|865240_866053_+|OmpA-family-protein
MRTRLVLAALVALSTGCVSQGKFNEKALEAEGLTKNLTDEKAARAAAEAKIKELEEKQAALEQEKTALQTRLDASENRLTGAAAERRALEEKNAQLAALNDELGRNAKKLAQAKEELEKKSSEYENLAQSLKQEISDGKIELSEMKGRMTVQLKDKILFASGSARVGKEGQEALVKIADALKTVKGRIVRVEGHTDDVPTGGGQFPTNWELSLARAMAVVRSLQDSGVDPTMLSAAGYGQYQPLVPNDTPEHKSQNRRIEIVLAPSLGGR
>NC_017030.1|WP_014393584.1|866083_868702_+|TonB-dependent-receptor
MKTLLCVVCVLLATGAVAQAPDAGTLAGDAGAPTGVLTKPPALLRQVEAAYPPDAAAQQLEGTVVMFIDISETGAVTNVEITQPAGHGFDEAATEAVKQFQFEPAEVDHVPAPVRIQYAYQFVFRAPEPPPEASPDGGVQEPQGPVNFSGQALERGTRKPLVGAEVVLTELDRSTVTDEDGRFAFRGVPVGTHPVVVVMGNYDRFKTQETIEEGKETRATYYVQKRIFSQYETVVRSDRERKEVTRTTITVAEVQRVPGTQGDTLKVVQNLPGVARPAFNGGALVIRGTSPQESGVFLDGLRIPILYHFGGLTSVYNSDLLEAVDYLPGNFSAYYGDITGGVINVRSREPRTDRLHATVGISLIESNAVVEGPITDTLSFAIGGRRSYIDLVLKAVPFDDDSLQVAPRYYDAQAKLVWKPSRRHTFTLQGLTSRDRLALLLDQPADGDPTVNGGLDVTTGFNQLRLRHQFREGKLLLDTHGLVGNTILDFQIGERGLRIASTDLYLRPTVEYAFNDNVTVAGGLDVVANLANVTASIQQPPREGEPPSPLVTEDLINIDGKFTQYYPSAWAEVRWRPLQDLLVVPGVRTESYIFTDQQEVKRTVNPRLAVRYALTETLTLKGGAGVYHSPPVQDEPSPGFGNPDLGAKRSLQYSVGAEWQARPEWFVGSEVFYNDLDDLIVRSNARVVRDGESVPENLKNGGVGRIYGFELLVRRALTDRLFGWISYTLSRSERRDAPGARWRKFDNDQTHVLTAIASYKLPKGWEVGARFRFATGNPTTPVLGSKRDDTTDVFIPYYGLVNSQRLPSFNQLDIRVDKTLIFDTWSLDLYLDLTNAYNNQSVEGVAYNYNYSKREYFKGLPILPVLGLKGAF
>NC_017030.1|WP_014393585.1|868706_869600_+|hypothetical-protein
MRTPVLLSVIALLGSTACSGPDFDAQSEIRGVRVLGIKAEPPELALEPNASTLPPPVTFSALAVTPDARPVTVTYALCRPDVNPYGDVACPGDSGVPLPGGVLSLSDPAVQALLIEAFQAATGSTGGGQGGSFDFNDPVVQQVLQTGLPLFVGYEATDGSGTPEGVERGVRRITLRSTDTPNQNPVMQDVLWNDAPLSGPLPLDAEVTFTPVLGEGSEETYSTVDGARTEQVFYSWFATGEGEVGSFRSLEPVDGKPGDPTTTYTTAKTPERITLWVVARDGRGGTDWTTRTVDVGP
>NC_017030.1|WP_014393586.1|869606_870173_-|hypothetical-protein
MTPSTEQLLAIARHYWPASVSDADEPGPELSRLFKRFGEALQGLGQWHGFLDHLRTLFPGFSIGDGTGPTRCSFRCIVYPAMGFPMPPIPWAVVGCMSILAPVFTVYGITFEYEGRKRRAAQLHLTPLPGPMEETARIVARELGARYQVSELPRGVAATPVPVVVDSTQPPQTTLFDALFDSDPTNIP
>NC_017030.1|WP_014393587.1|870191_870641_-|hypothetical-protein
MLALCVACVGPTDRTFVTGRILPRQIRFVTLREATPGEEGGQRSACIHVRLTRANTSESVLCRFGVETPLHNVEGPISTALAQRIAADRINEATQANFSAATIASPLGMLCESVKATLRTTVPASIAGAKVPAVCHERALPVHFGDFTL
>NC_017030.1|WP_043320998.1|871168_871675_+|hypothetical-protein
MSAMRCGGLGLVGGVLLLAGCLRGQGARPADWEGDRSIAFPPFYVQSAVQLGGEEQAYVLDGNLLRAVQVSMDDFFPKRSKDTPCWGTPEAYRYRVIRQGTVFFILIHEARDACGNTFIGVDTGARYAVSLDGRILRRSVGAEPEAPPASPGIDSGVLEGVALDGGAP

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Crispr_ID: NC_017030_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_3

957469-957582

Orphan

Consensus_repeat	Method
GGCGGCGGGAGCGGGGACCGCGCCGATGCCGCAAGGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_3

>merge|NC_017030|3|957469-957582|CRISPRCasFinder
GGCGGCGGGAGCGGGGACCGCGCCGATGCCGCAAGGAGCCCACGTGGGGATTGGCGCCGCAGTGGCTCCGGCGTGGGCGGCGGGAGCGGGGACCGCGCCGATGCCGCAAGGAGC

>NC_017030|3|2|957469-957582|CRISPRCasFinder
GGCGGCGGGAGCGGGGACCGCGCCGATGCCGCAAGGAGC	CCACGTGGGGATTGGCGCCGCAGTGGCTCCGGCGTG
GGCGGCGGGAGCGGGGACCGCGCCGATGCCGCAAGGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_148282475.1\|969581_970808_-\|C39-family-peptidase	unknown	unknown	gnl\|CDD\|239109
NC_017030.1\|WP_014393660.1\|949720_950767_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176186
NC_017030.1\|WP_014393668.1\|958029_958524_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_193352551.1\|949368_949737_+\|DoxX-family-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393666.1\|955432_956041_-\|DUF2378-family-protein	unknown	unknown	gnl\|CDD\|370550
NC_017030.1\|WP_014393673.1\|962547_966003_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014393664.1\|954010_955024_+\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176237
NC_017030.1\|WP_014393669.1\|958599_959232_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NC_017030.1\|WP_014393671.1\|961312_961792_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NC_017030.1\|WP_014393658.1\|948673_949189_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393672.1\|961809_962154_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NC_017030.1\|WP_043322605.1\|966122_966929_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NC_017030.1\|WP_014393670.1\|959312_960215_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187572
NC_017030.1\|WP_014393676.1\|967901_969341_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NC_017030.1\|WP_014393657.1\|948122_948641_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_017030.1\|WP_014393675.1\|967056_967905_+\|DUF1206-domain-containing-protein	unknown	unknown	gnl\|CDD\|377695
NC_017030.1\|WP_014393661.1\|950870_951776_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176163
NC_017030.1\|WP_014393663.1\|953347_953962_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393662.1\|951781_953260_-\|putative-lipoprotein	unknown	unknown	gnl\|CDD\|283275
NC_017030.1\|WP_014393665.1\|955010_955412_-\|TonB-family-protein	unknown	unknown	gnl\|CDD\|372476

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014393660.1\|949720_950767_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176186	cd05283, CAD1, Cinnamyl alcohol dehydrogenases (CAD). Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NC_017030.1\|WP_014393662.1\|951781_953260_-\|putative-lipoprotein	gnl\|CDD\|283275	pfam05576, Peptidase_S37, PS-10 peptidase S37. These serine proteases have been found in Streptomyces species.	1.05122e-99
NC_017030.1\|WP_014393675.1\|967056_967905_+\|DUF1206-domain-containing-protein	gnl\|CDD\|377695	pfam06724, DUF1206, Domain of Unknown Function (DUF1206). This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.	2.44121e-13
NC_017030.1\|WP_014393666.1\|955432_956041_-\|DUF2378-family-protein	gnl\|CDD\|370550	pfam09536, DUF2378, Protein of unknown function (DUF2378). This family consists of a set of at least 17 paralogous proteins in Myxococcus xanthus DK 1622 and and 12 in Stigmatella aurantiaca DW4/3-1. Members are about 200 amino acids in length. The function is unknown.	3.46687e-55
NC_017030.1\|WP_014393673.1\|962547_966003_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.53399e-88
NC_017030.1\|WP_014393664.1\|954010_955024_+\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176237	cd08276, MDR7, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NC_017030.1\|WP_014393669.1\|958599_959232_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	3.2022e-18
NC_017030.1\|WP_043322605.1\|966122_966929_+\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	5.25033e-21
NC_017030.1\|WP_014393672.1\|961809_962154_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	1.28332e-09
NC_017030.1\|WP_014393676.1\|967901_969341_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	9.16985e-112
NC_017030.1\|WP_014393657.1\|948122_948641_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	2.59264e-22
NC_017030.1\|WP_148282475.1\|969581_970808_-\|C39-family-peptidase	gnl\|CDD\|239109	cd02549, Peptidase_C39A, A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature or have different domain architectures.	5.99101e-21
NC_017030.1\|WP_014393661.1\|950870_951776_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176163	cd08474, PBP2_CrgA_like_5, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 5. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.59232e-82
NC_017030.1\|WP_014393671.1\|961312_961792_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	9.37445e-31
NC_017030.1\|WP_014393670.1\|959312_960215_+\|SDR-family-oxidoreductase	gnl\|CDD\|187572	cd05262, SDR_a7, atypical (a) SDRs, subgroup 7. This subgroup contains atypical SDRs of unknown function. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.20175e-123
NC_017030.1\|WP_014393665.1\|955010_955412_-\|TonB-family-protein	gnl\|CDD\|372476	pfam13103, TonB_2, TonB C terminal. This family contains TonB members that are not captured by pfam03544.	3.60211e-10

>NC_017030.1|WP_014393666.1|955432_956041_-|DUF2378-family-protein
MTPERLVFQQSFEGLIRALGDHLDEPCARQLRDVGIDPRGKLAVAYPLEVWVESLKLAASVLAPAATLDDGAEVVGRRFLEGYGATLIGSALLAGVRLLGPHRMLERMTRNLRTGTNYLEARLEQTGPTRYVLTCRPVVVAGFYRGLFSAGLEMSGAHGASVVLMRAAGDAAVYDLSWLPEKGASKPPEAKPLPPRGPQPRN
>NC_017030.1|WP_014393665.1|955010_955412_-|TonB-family-protein
MLRIPKTAVVVLALALASGALAASGSPQLQTYFQGSVDSPTYQQQAFQRVAKAWKQPGPKGTPALGKKTIVQAVLDKDGKLVSTAILTESGAKAWDAAALAAVKKAAPFPPLPKSTATATVEAHFHFAWVSSP
>NC_017030.1|WP_014393664.1|954010_955024_+|NAD(P)-dependent-alcohol-dehydrogenase
MNVYEIRGAFGLDNLVRAERPDPVPGPFQVRVRVKATSLNSRDLMMVEGRYNPRQKLPLVPNSDGAGVVDAVGPGVTRVKVGDRVMTLFAQGWQSGEPTKAITATTLGGPLDGALADTLLLHEDGVVPTPAYLSDEEAATLPCAAVTAWSALVTQGGLKAGDTVLVQGTGGVSIFALQIARLFGAHVIVTSSRDDKLERALKLGAHEGINYVTTPDWEKAARTLTGGVGVDHVVEVGGSGTFEKSLKALRVGGTVSVIGVLSGGAGTVSLVPILMQNLRVQGVFVGHRQSFEALTRAFTLHDVHPVVDRVFPFAEARAAFEHMKQGAHFGKIVIKVS
>NC_017030.1|WP_014393663.1|953347_953962_-|hypothetical-protein
MSLLQKLMEHASLHEPCGTAGKRAHLKAGLQPSAATKQVDGDLTLTEGTDLVFEEGRVHVKGHLLLEEQSRLLVAGDLVVEGNIVHEGFDYALLFAGGSIQADNLLFHGELVALGGLTLRGAAWTYYNDYSTYADTLTARAVVADDRADAVDQVHADTHLEGHARVIAGALEQLLHPDAWARYQEGSYAALARHLRQGQPLLRK
>NC_017030.1|WP_014393662.1|951781_953260_-|putative-lipoprotein
MSRFFGRPAVLACALALGLQACGGSELPPESITPSAPEVQAQSLTQDAAPDILAQLQAIPGLTVVQEQPAPAPGVRFFVLTYDQPADHLRPNGTRFQQRMTLRYRSAEAPMVLASTGYGISTFSFQLEPTFLLQGNQLLVEHRFFEPSRPQPADWRLLSIEQAAADHHRIVQAFKPLFPGKWISTGGSKGGMTSLYHRAFFPRDVDATVAYVAPNSYGTQDPRYVKFLSKLGTPECREDIRNFQHEVLARRSETAPLFQAAGAANYGSTYDFLGVDKALEFSTLEVAFAFWQHGNASLCDLIPQPGAPAEALVGFLDRVVGLSYMSDGDLDYYAAYDFQAATQLGSYASEEGHLRGLLRYPRQYDPRNLVPFNMGPYPFNPLAMPLVEGWVKAFGERILLVYGENDPWSTGAFSVSARNDSYRFFEPGGNHGASITRLPEADQAVALERLRTWAGLPAQSTAEMSLRAKSAKSSGEPITTGVVDRRRGPPRD
>NC_017030.1|WP_014393661.1|950870_951776_+|LysR-family-transcriptional-regulator
MATTPLNALNAFLAVGRRRSFASAAIELGISPSALSQQVRHLESRLGVPLLTRTTRSVALTDAGQRLLERAGPSVAQALEALEAATASAGDITGRVRLSVPTISLSTVVTPILLRFAQRHPQVEVELRIEDRFVDIVAEGLDAGIRPFEAVERDMVQVRLSKRFRYVVVGSPAYLKRKGTPQRPEDLLDHDCVNIVLPSSGAKYAWELERGRKTWRIPVRGPVLATNEEVLVAMAEAGLALMYAFEPTIVPRLKRGTLKLVLEPYAAWMEGLFLYFPSRAQVSPAFRAFLDVAREVTAARD
>NC_017030.1|WP_014393660.1|949720_950767_-|NAD(P)-dependent-alcohol-dehydrogenase
MISARGYAAPDASSPLAPYPFERREPGPRDVQLDVLYCGVCHTDLHMVRNDWGFSTYPLVPGHEIVGRVVRVGSDVTKFRPGDLAGVGTMVDSCRACVDCRDGYEQYCKVQGVLTYGSRERDGKGITQGGYSDRLVVDEHFALKVPGNLDPAAVAPLLCAGITTYSPLRHWKVGPGQKVGVVGLGGLGHLGVKFALALGAHVTVFSHTDRKKQDALRLGAHEVVVSSRPEEMAAKANSLDFILDTVSAVHDVNAYLDLLRRDGHLVLVGFPSRPLEVAPVALLSRRASFSGSGTGGLPETQAMLDFCGEHGIVSDIELIPIQGINEAFTRLEKGDVKYRFVLDLKSLG
>NC_017030.1|WP_193352551.1|949368_949737_+|DoxX-family-protein
MGLVFFVFGLNGFLEFIPTPKDLSPTDPAVAFGIAMKATGFLFALVKGTETVVGLLLLANRFVPLALALIAPVIVNIFLTHAFLAPSGLGMAVMLLAAELFLAWSYRAAYRPMLAMKVNPGS
>NC_017030.1|WP_014393658.1|948673_949189_+|hypothetical-protein
MANPLSVLGIIHTLVSVPPIVFGVWAFVRDGRIDPGTRVGKAYVASMVASVVTSFGLSSTGGFNPGHALGLVALLLMAVGAAAPGLGVFGRATEYVRTLTYSASFMVLLLPGINETLTRLPADKPLADSPQSPVVQAALATLLGLFLCGATYQVLRLRARKYDHVGGLSHR
>NC_017030.1|WP_014393657.1|948122_948641_+|sigma-70-family-RNA-polymerase-sigma-factor
MGSTPTPDALLLAAHAGDRDAMVHLLQLQQPNLRRYAQKRCLISDVDDAVQEALLVMSRQLSAVRQLASFSGWMFKIVQRECRRLARTVMKNDPYEEALVDQWMSAHTPDSLRLDMASALESLPPQYLEVVVLRDFEALSIREMAERLSLDPAAVKSRLHRARVMIREYLLA
>NC_017030.1|WP_014393668.1|958029_958524_+|hypothetical-protein
MRSRVLFPLCLTGLLLACASGGARSTPSEAASSDSGPVQPCSVNPTPPEGTTQVLITARPDGKVHFSSTTVQVRAGQTVSFVSQVQQDRCIGVSNSGLLKDGSQNPLPVPACQVASWKLRAADEPGTTTSLWSCPTSDCSKCTQSQGIRETINGTLEVTGRGED
>NC_017030.1|WP_014393669.1|958599_959232_-|TetR-family-transcriptional-regulator
MGRWEPNARDRLAQAAMTLFQEHGYDRTTVEEIAARAGLTERTFFRYFTDKKEVLFGGSDALHERIVTTIAEAPPGAAPLDTVAAALESLTPFFKDRRDHARARQTLLVAHAELRERELIKLASLASAAAETLRKRGVTEPTASLAAEAGIAVFKVAFERWLEDPKAQDLSRHIQLGLDELRAVTASTSATVTPAAPPRQPARPARARKP
>NC_017030.1|WP_014393670.1|959312_960215_+|SDR-family-oxidoreductase
MRVFVTGASGFIGSAVVPELLGAGHQVVGLARSDASARALEAAGAEVHRGSLDDPDSLRAGAAKADGVIHLAFIHDFSRFEDSVRADARAIEAMGKALEGSQRPLVIAAGLLFLTPGRVAVETDAAAPTGRGAAEATMLALAERGVRTSIVRLPPSVHGKGDHGFVPHLITSARRTGVAAYVGEGVNRWPAVHRSDAARLFRLALERAPAGSRLHAVADEGVPTRDIAAVIGRRVGVPVASKTPAEAGDFLGFLGALFALDAPASSTRTREQLGWRPEGPGLLADLDDGHYFAPDAGTIL
>NC_017030.1|WP_014393671.1|961312_961792_-|PaaI-family-thioesterase
MSGTKSPFGPQVFTPADASFEQRVRASFARQRVMDTLGASLTSVAPGEVVIELPFREDFTQQHGYLHAAIVTAIVDSACGYAAYSLMPVDAAVLTVEYKVNFLAPAAGRKFIAQGRVTKPGRTLTVTTGDVFAETDAGLKPVATMLATMMAVSHRETSG
>NC_017030.1|WP_014393672.1|961809_962154_-|VOC-family-protein
MPLALYAGIAVSDYATACDWYSRLFGGPPTLVATPTKAVWDLAEHRSICIDERPEHAGHANLSIFVDDLDSLVARIAERGIHAEKQETYKDGVRRATYRDPDGNEIGFGSAPQL
>NC_017030.1|WP_014393673.1|962547_966003_-|protein-kinase
MALAEGLLSREDVDALREEAARRGVSPLQLLVEQGRLTADSLVSLRRSLEVERNAPPGTADDTLPPGAAPASVTDGPAFPVPHWTLYRPLRFLGQGGMGRVFLARDLRLHRDVALKFVRDEDPELSRRFISEARAQARVDHERVCRVYEVGEVQGRAYIAMQYIAGAPLHTLAGTLSVEQKALVLRDATLGVHAAHLAGLVHRDLKPSNILVERGEDGALRPYVMDFGLARDWSSDDAATATGTVLGTPQYMAPEQARGEVTRLDRRADIYSLGATLYHLLTGQPPVTGANGLEVLGRIATQEPRRPRELDAGIPADLEAIVLKCLEKDRSRRYGSARALADDLTRFLEGDRVLARTGPAYRVRKWMARHRVAVVVASITGLAVAGAVGQGVMARREVARREALTRRFTEGIERIEAQARYSGQAPLHDTRPDREVMLARMRDIEATMRDAGPVAEGPGHYALGRGFLALGDEEAALTHLEAAWAKGFREPRVAYALALVLGHRYQRERLEADRIPDAARREAKRREAWAHSRDPALAFLEQGRGAEMPAPEYAEALRAFHQERFEDALKSLDALGTRLPWFHEAPRLRGDVLLARAVRHALASERDAARDDLEAGRRAYDAAADIGRSVSAVHRARAELEQEALILELSGKGDVLPAYTRGMEAVSRARTAAPDEADTWVLEARLHRRLAQASLSSGGDVEPLLERTLDAAKEALRLAPERVEARHALAMGWWQWARYRQDRNEDPREQLKAAVAAFESIPESARDYDFHLDLGLVFKVWADSEDGRGGDSLPFRQQAITAYRQALALDAKRPDAWINLGTAHVNRANHPRAPSKDADLEEARTALERASTLDPGHVVAWFYLADVHRTLALRLRDHGGDAGPGLARALEAYRQGVAINAKLPPLQNGVGTILLDQAREAWDRGDSPESLLDQAEQAFLQAIAIAPKVGFAHNNLGEVRMWRATWRLLRDQDPTASAKEAQAELQQATTLLPGLAEPWANLGQVHHTEAAYALKQGKDPRPSLARATEALERALKLNPSLAQAWRWRGEVRALQAREEVRRGQKPDASFQAAASDFQKALELDPENLDPRLAYSAFLREWGATASGPDARAHLQQGLSLTETVLTARPRWKDASTLRDGLLRALAKLPPE
>NC_017030.1|WP_043322605.1|966122_966929_+|alpha/beta-hydrolase
MSSMWVLETPQPPPDARIAYGEAPQQFTELRKPKGKGPHPVVLFVHGGFWRAEYGLEHAGHLCADLTKRGFATWSLEYRRVGQDGGGFPGTLEDVASAADHLMSAAPSLGLDLSNVVAMGHSAGGHLAMWLAARHRLPPKHPLYRDAPLKLKGVVSLAGVLDLAQGAALDLGNGIVKTFMGGTPEQVPERYAVASPAALQPLKLPQVLIHGTEDDTVPLKVSEGFHARGVQQKDPVHLVPLKGAGHFELIDPRSKEWPRVVQAVKNLR
>NC_017030.1|WP_014393675.1|967056_967905_+|DUF1206-domain-containing-protein
MATMDVMRGPGMDRLSRGAKEAANHPWAKKLGRMGYAAKGCVYAIIGVLALKLAAGEGGRATDSHGAVATVAQGPFGIVLLSLLAVGLVGYVVWRFAQAFADTEDKGSDAKGIATRAMYFVSGVIYGSLALFAVKTVVGSSQGKGKGTQGWTATLMEQPFGRVLVVLVGLGIIGFAVKQFHTAWKAKFREKLTLTGLAATHQHRVERVCQFGIAARGVVFTVIGGFLVLAGVDANPGEAKGLGEALAVVARQPAGDVLLGVVAAGLVAYAAYLFLQARYREL
>NC_017030.1|WP_014393676.1|967901_969341_-|glutamine-synthetase
MEQKPLRDFLEIPYDELEELNLKVKRQRIKRESPDKIREERIKYLTDEKRIKAVTVCFTDLEGRLHMLDYDKKFLLKSADNLTFDGSSIRGFSAQAESDLRLNVDWSAFYWLPSDIFGPGKVLAFCEVLERDGTPYHSDMRGQLKRATEQLFQKDGTVFHAAPEIEGFLFKNRDAERHYHEEGKFEFISIGGYYHALPGDGLRAFIDKAAEAQRAMGFENEKDHPEVAPSQFEMNFSYSEALVAADQIQLYKLLCRQVAAQQGLTASFLPKPVTGVNGNGMHINMSLSKNNKNLFYDKGGQDGLSAMGWEFIDRILNNANDICLVLNSSVNSYRRLDPHYEAPNQIKASANNRGAMVRIPFGNERSARVECRSVAPDANPYMVLFTLLKTGLEGPQPQEDAETKRSRTRFLPDNIYDAVRFFKGSQFIAQTLGEQVQGKYAELKVAAADRCPKQLGTRVKDAEIQFHHEVTNQYLWNLF
>NC_017030.1|WP_148282475.1|969581_970808_-|C39-family-peptidase
MLATCIWACASSPPSPSSDAPQETGSPARLWQKTSVSGDLARFSRDGTRVTADGALELDPSTAKEGTDPFPAGGWLDGGSFYNGGTFRVGTATSEVQSVPGGFDSVVPSFDAQTPPGTWVKLTVSARVEGTWTKDYELGVWAFDTTTVARHSVDNQGDADGNVLTDTLNLKRRADALRVTVHLFSERADVSPRVRALAAAVTDTRLKPQDATSDRTGWGVVLDVPGYSQMIYPDGGEVWCSPTSTTMLLGYWSRKLGRADLEHPVPTAAAHTYDWVYKGTGNWAFNTAYAASMSNGALHGLVARFDSFAPVERLVAAGIPVSISIAYEPGELPGGASRRTDGHLIVVKGFTDTGDVVGNDPAFGSNETTHATYPRAELWRAWQHSRGAAYVLWPAGTPLPEQGLVPLP

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Crispr_ID: NC_017030_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_4

960752-960992

Orphan

Consensus_repeat	Method
GCGGAAACCTGTCGGACAGTCGGACAGGTT	PILER-CR

3 spacers

The CRISPR arrays of NC_017030_4

>merge|NC_017030|4|960752-960992|PILER-CR
GCGGAAACCTGTCCGACAGTCGGACAGGTTGGACAACCGTGTCGGCGGGGGCCACGCCGCTCCAGGCGAGCCGAGGAAACCTGTCGGACAGTCGGACAGGTTCAGGTGAACCCGGACCGAGGGTTGCTGCTCCGTCCGGGTAGCGGAAACCTGTCGGACAGTCGGACAGGTTTGGGCGGCCGTGTCCGCAGGGGCGCCACTCCAGCCGAGCGCGGAAACCTGTCGGACAGTCGGACAGCTT

>NC_017030|4|1|960752-960992|PILER-CR
GCGGAAACCTGTCCGACAGTCGGACAGGTT	GGACAACCGTGTCGGCGGGGGCCACGCCGCTCCAGGCGAGCC
GAGGAAACCTGTCGGACAGTCGGACAGGTT	CAGGTGAACCCGGACCGAGGGTTGCTGCTCCGTCCGGGTA
GCGGAAACCTGTCGGACAGTCGGACAGGTT	TGGGCGGCCGTGTCCGCAGGGGCGCCACTCCAGCCGAGC
GCGGAAACCTGTCGGACAGTCGGACAGCTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014393680.1\|971918_972602_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_148282475.1\|969581_970808_-\|C39-family-peptidase	unknown	unknown	gnl\|CDD\|239109
NC_017030.1\|WP_014393667.1\|956221_957952_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_017030.1\|WP_014393668.1\|958029_958524_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393666.1\|955432_956041_-\|DUF2378-family-protein	unknown	unknown	gnl\|CDD\|370550
NC_017030.1\|WP_014393673.1\|962547_966003_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014393664.1\|954010_955024_+\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176237
NC_017030.1\|WP_014393679.1\|971502_971904_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376540
NC_017030.1\|WP_014393663.1\|953347_953962_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393675.1\|967056_967905_+\|DUF1206-domain-containing-protein	unknown	unknown	gnl\|CDD\|377695
NC_017030.1\|WP_014393672.1\|961809_962154_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NC_017030.1\|WP_043322605.1\|966122_966929_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NC_017030.1\|WP_014393670.1\|959312_960215_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187572
NC_017030.1\|WP_014393669.1\|958599_959232_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NC_017030.1\|WP_014393676.1\|967901_969341_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NC_017030.1\|WP_014393678.1\|970983_971466_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014393661.1\|950870_951776_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176163
NC_017030.1\|WP_014393671.1\|961312_961792_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NC_017030.1\|WP_014393662.1\|951781_953260_-\|putative-lipoprotein	unknown	unknown	gnl\|CDD\|283275
NC_017030.1\|WP_014393665.1\|955010_955412_-\|TonB-family-protein	unknown	unknown	gnl\|CDD\|372476

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_148282475.1\|969581_970808_-\|C39-family-peptidase	gnl\|CDD\|239109	cd02549, Peptidase_C39A, A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature or have different domain architectures.	5.99101e-21
NC_017030.1\|WP_014393667.1\|956221_957952_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	4.16892e-89
NC_017030.1\|WP_014393675.1\|967056_967905_+\|DUF1206-domain-containing-protein	gnl\|CDD\|377695	pfam06724, DUF1206, Domain of Unknown Function (DUF1206). This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.	2.44121e-13
NC_017030.1\|WP_014393666.1\|955432_956041_-\|DUF2378-family-protein	gnl\|CDD\|370550	pfam09536, DUF2378, Protein of unknown function (DUF2378). This family consists of a set of at least 17 paralogous proteins in Myxococcus xanthus DK 1622 and and 12 in Stigmatella aurantiaca DW4/3-1. Members are about 200 amino acids in length. The function is unknown.	3.46687e-55
NC_017030.1\|WP_014393673.1\|962547_966003_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.53399e-88
NC_017030.1\|WP_014393664.1\|954010_955024_+\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176237	cd08276, MDR7, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NC_017030.1\|WP_014393669.1\|958599_959232_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	3.2022e-18
NC_017030.1\|WP_043322605.1\|966122_966929_+\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	5.25033e-21
NC_017030.1\|WP_014393672.1\|961809_962154_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	1.28332e-09
NC_017030.1\|WP_014393676.1\|967901_969341_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	9.16985e-112
NC_017030.1\|WP_014393670.1\|959312_960215_+\|SDR-family-oxidoreductase	gnl\|CDD\|187572	cd05262, SDR_a7, atypical (a) SDRs, subgroup 7. This subgroup contains atypical SDRs of unknown function. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.20175e-123
NC_017030.1\|WP_014393679.1\|971502_971904_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	3.80723e-11
NC_017030.1\|WP_014393661.1\|950870_951776_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176163	cd08474, PBP2_CrgA_like_5, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 5. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.59232e-82
NC_017030.1\|WP_014393671.1\|961312_961792_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	9.37445e-31
NC_017030.1\|WP_014393662.1\|951781_953260_-\|putative-lipoprotein	gnl\|CDD\|283275	pfam05576, Peptidase_S37, PS-10 peptidase S37. These serine proteases have been found in Streptomyces species.	1.05122e-99
NC_017030.1\|WP_014393665.1\|955010_955412_-\|TonB-family-protein	gnl\|CDD\|372476	pfam13103, TonB_2, TonB C terminal. This family contains TonB members that are not captured by pfam03544.	3.60211e-10

>NC_017030.1|WP_014393670.1|959312_960215_+|SDR-family-oxidoreductase
MRVFVTGASGFIGSAVVPELLGAGHQVVGLARSDASARALEAAGAEVHRGSLDDPDSLRAGAAKADGVIHLAFIHDFSRFEDSVRADARAIEAMGKALEGSQRPLVIAAGLLFLTPGRVAVETDAAAPTGRGAAEATMLALAERGVRTSIVRLPPSVHGKGDHGFVPHLITSARRTGVAAYVGEGVNRWPAVHRSDAARLFRLALERAPAGSRLHAVADEGVPTRDIAAVIGRRVGVPVASKTPAEAGDFLGFLGALFALDAPASSTRTREQLGWRPEGPGLLADLDDGHYFAPDAGTIL
>NC_017030.1|WP_014393669.1|958599_959232_-|TetR-family-transcriptional-regulator
MGRWEPNARDRLAQAAMTLFQEHGYDRTTVEEIAARAGLTERTFFRYFTDKKEVLFGGSDALHERIVTTIAEAPPGAAPLDTVAAALESLTPFFKDRRDHARARQTLLVAHAELRERELIKLASLASAAAETLRKRGVTEPTASLAAEAGIAVFKVAFERWLEDPKAQDLSRHIQLGLDELRAVTASTSATVTPAAPPRQPARPARARKP
>NC_017030.1|WP_014393668.1|958029_958524_+|hypothetical-protein
MRSRVLFPLCLTGLLLACASGGARSTPSEAASSDSGPVQPCSVNPTPPEGTTQVLITARPDGKVHFSSTTVQVRAGQTVSFVSQVQQDRCIGVSNSGLLKDGSQNPLPVPACQVASWKLRAADEPGTTTSLWSCPTSDCSKCTQSQGIRETINGTLEVTGRGED
>NC_017030.1|WP_014393667.1|956221_957952_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MPHDALADVSTAAMQERGGARGTPRAVPALTVVSHPVPQRVGERLLLDAVVAGRTLALSRNAPDFAKPGSSLGLPLADPFVSRKPLELSALAAGGVRLSVPEDGTHVVAAGGPLQGARDFGPAELMDGVALELSGRVVLLLHTVELDGEGLVDTQGMVGESAGLRRLRKHIERVADLDVSVLIRGETGTGKELVAQAIHRLSPRRDGRFVSVNLGAIPKELAAAELFGSKKGAYSGATQDREGFFRAAHGGTLFLDEVGEAPPEVQVMLLRVLETGELYPVGASQPVKVDVRLIAATDAHLEEQIRDGRFKAPLLHRLAGYDLRVPALRERREDVGRLFFHFAREELAALGDAARLDSEDPHAEPWLPAPLASRLVRAAWPGNIRQLRNLTRQLVIGSRGQARLQLDPQLEEALGTAAGAGTAPMPQGAHVGIGAAVAPAWAAGAGTAPMPQGAQASAGTPVAPARGADAPEAREAAVPRRKPSQVTEAELLAALRASAWDLKAAADALGIPRPSVYDLIERSPNLRTAGDLGADEITRCFEACGGDLDAMVRTLEVSKRALGRRLKELGLTAKAP
>NC_017030.1|WP_014393666.1|955432_956041_-|DUF2378-family-protein
MTPERLVFQQSFEGLIRALGDHLDEPCARQLRDVGIDPRGKLAVAYPLEVWVESLKLAASVLAPAATLDDGAEVVGRRFLEGYGATLIGSALLAGVRLLGPHRMLERMTRNLRTGTNYLEARLEQTGPTRYVLTCRPVVVAGFYRGLFSAGLEMSGAHGASVVLMRAAGDAAVYDLSWLPEKGASKPPEAKPLPPRGPQPRN
>NC_017030.1|WP_014393665.1|955010_955412_-|TonB-family-protein
MLRIPKTAVVVLALALASGALAASGSPQLQTYFQGSVDSPTYQQQAFQRVAKAWKQPGPKGTPALGKKTIVQAVLDKDGKLVSTAILTESGAKAWDAAALAAVKKAAPFPPLPKSTATATVEAHFHFAWVSSP
>NC_017030.1|WP_014393664.1|954010_955024_+|NAD(P)-dependent-alcohol-dehydrogenase
MNVYEIRGAFGLDNLVRAERPDPVPGPFQVRVRVKATSLNSRDLMMVEGRYNPRQKLPLVPNSDGAGVVDAVGPGVTRVKVGDRVMTLFAQGWQSGEPTKAITATTLGGPLDGALADTLLLHEDGVVPTPAYLSDEEAATLPCAAVTAWSALVTQGGLKAGDTVLVQGTGGVSIFALQIARLFGAHVIVTSSRDDKLERALKLGAHEGINYVTTPDWEKAARTLTGGVGVDHVVEVGGSGTFEKSLKALRVGGTVSVIGVLSGGAGTVSLVPILMQNLRVQGVFVGHRQSFEALTRAFTLHDVHPVVDRVFPFAEARAAFEHMKQGAHFGKIVIKVS
>NC_017030.1|WP_014393663.1|953347_953962_-|hypothetical-protein
MSLLQKLMEHASLHEPCGTAGKRAHLKAGLQPSAATKQVDGDLTLTEGTDLVFEEGRVHVKGHLLLEEQSRLLVAGDLVVEGNIVHEGFDYALLFAGGSIQADNLLFHGELVALGGLTLRGAAWTYYNDYSTYADTLTARAVVADDRADAVDQVHADTHLEGHARVIAGALEQLLHPDAWARYQEGSYAALARHLRQGQPLLRK
>NC_017030.1|WP_014393662.1|951781_953260_-|putative-lipoprotein
MSRFFGRPAVLACALALGLQACGGSELPPESITPSAPEVQAQSLTQDAAPDILAQLQAIPGLTVVQEQPAPAPGVRFFVLTYDQPADHLRPNGTRFQQRMTLRYRSAEAPMVLASTGYGISTFSFQLEPTFLLQGNQLLVEHRFFEPSRPQPADWRLLSIEQAAADHHRIVQAFKPLFPGKWISTGGSKGGMTSLYHRAFFPRDVDATVAYVAPNSYGTQDPRYVKFLSKLGTPECREDIRNFQHEVLARRSETAPLFQAAGAANYGSTYDFLGVDKALEFSTLEVAFAFWQHGNASLCDLIPQPGAPAEALVGFLDRVVGLSYMSDGDLDYYAAYDFQAATQLGSYASEEGHLRGLLRYPRQYDPRNLVPFNMGPYPFNPLAMPLVEGWVKAFGERILLVYGENDPWSTGAFSVSARNDSYRFFEPGGNHGASITRLPEADQAVALERLRTWAGLPAQSTAEMSLRAKSAKSSGEPITTGVVDRRRGPPRD
>NC_017030.1|WP_014393661.1|950870_951776_+|LysR-family-transcriptional-regulator
MATTPLNALNAFLAVGRRRSFASAAIELGISPSALSQQVRHLESRLGVPLLTRTTRSVALTDAGQRLLERAGPSVAQALEALEAATASAGDITGRVRLSVPTISLSTVVTPILLRFAQRHPQVEVELRIEDRFVDIVAEGLDAGIRPFEAVERDMVQVRLSKRFRYVVVGSPAYLKRKGTPQRPEDLLDHDCVNIVLPSSGAKYAWELERGRKTWRIPVRGPVLATNEEVLVAMAEAGLALMYAFEPTIVPRLKRGTLKLVLEPYAAWMEGLFLYFPSRAQVSPAFRAFLDVAREVTAARD
>NC_017030.1|WP_014393671.1|961312_961792_-|PaaI-family-thioesterase
MSGTKSPFGPQVFTPADASFEQRVRASFARQRVMDTLGASLTSVAPGEVVIELPFREDFTQQHGYLHAAIVTAIVDSACGYAAYSLMPVDAAVLTVEYKVNFLAPAAGRKFIAQGRVTKPGRTLTVTTGDVFAETDAGLKPVATMLATMMAVSHRETSG
>NC_017030.1|WP_014393672.1|961809_962154_-|VOC-family-protein
MPLALYAGIAVSDYATACDWYSRLFGGPPTLVATPTKAVWDLAEHRSICIDERPEHAGHANLSIFVDDLDSLVARIAERGIHAEKQETYKDGVRRATYRDPDGNEIGFGSAPQL
>NC_017030.1|WP_014393673.1|962547_966003_-|protein-kinase
MALAEGLLSREDVDALREEAARRGVSPLQLLVEQGRLTADSLVSLRRSLEVERNAPPGTADDTLPPGAAPASVTDGPAFPVPHWTLYRPLRFLGQGGMGRVFLARDLRLHRDVALKFVRDEDPELSRRFISEARAQARVDHERVCRVYEVGEVQGRAYIAMQYIAGAPLHTLAGTLSVEQKALVLRDATLGVHAAHLAGLVHRDLKPSNILVERGEDGALRPYVMDFGLARDWSSDDAATATGTVLGTPQYMAPEQARGEVTRLDRRADIYSLGATLYHLLTGQPPVTGANGLEVLGRIATQEPRRPRELDAGIPADLEAIVLKCLEKDRSRRYGSARALADDLTRFLEGDRVLARTGPAYRVRKWMARHRVAVVVASITGLAVAGAVGQGVMARREVARREALTRRFTEGIERIEAQARYSGQAPLHDTRPDREVMLARMRDIEATMRDAGPVAEGPGHYALGRGFLALGDEEAALTHLEAAWAKGFREPRVAYALALVLGHRYQRERLEADRIPDAARREAKRREAWAHSRDPALAFLEQGRGAEMPAPEYAEALRAFHQERFEDALKSLDALGTRLPWFHEAPRLRGDVLLARAVRHALASERDAARDDLEAGRRAYDAAADIGRSVSAVHRARAELEQEALILELSGKGDVLPAYTRGMEAVSRARTAAPDEADTWVLEARLHRRLAQASLSSGGDVEPLLERTLDAAKEALRLAPERVEARHALAMGWWQWARYRQDRNEDPREQLKAAVAAFESIPESARDYDFHLDLGLVFKVWADSEDGRGGDSLPFRQQAITAYRQALALDAKRPDAWINLGTAHVNRANHPRAPSKDADLEEARTALERASTLDPGHVVAWFYLADVHRTLALRLRDHGGDAGPGLARALEAYRQGVAINAKLPPLQNGVGTILLDQAREAWDRGDSPESLLDQAEQAFLQAIAIAPKVGFAHNNLGEVRMWRATWRLLRDQDPTASAKEAQAELQQATTLLPGLAEPWANLGQVHHTEAAYALKQGKDPRPSLARATEALERALKLNPSLAQAWRWRGEVRALQAREEVRRGQKPDASFQAAASDFQKALELDPENLDPRLAYSAFLREWGATASGPDARAHLQQGLSLTETVLTARPRWKDASTLRDGLLRALAKLPPE
>NC_017030.1|WP_043322605.1|966122_966929_+|alpha/beta-hydrolase
MSSMWVLETPQPPPDARIAYGEAPQQFTELRKPKGKGPHPVVLFVHGGFWRAEYGLEHAGHLCADLTKRGFATWSLEYRRVGQDGGGFPGTLEDVASAADHLMSAAPSLGLDLSNVVAMGHSAGGHLAMWLAARHRLPPKHPLYRDAPLKLKGVVSLAGVLDLAQGAALDLGNGIVKTFMGGTPEQVPERYAVASPAALQPLKLPQVLIHGTEDDTVPLKVSEGFHARGVQQKDPVHLVPLKGAGHFELIDPRSKEWPRVVQAVKNLR
>NC_017030.1|WP_014393675.1|967056_967905_+|DUF1206-domain-containing-protein
MATMDVMRGPGMDRLSRGAKEAANHPWAKKLGRMGYAAKGCVYAIIGVLALKLAAGEGGRATDSHGAVATVAQGPFGIVLLSLLAVGLVGYVVWRFAQAFADTEDKGSDAKGIATRAMYFVSGVIYGSLALFAVKTVVGSSQGKGKGTQGWTATLMEQPFGRVLVVLVGLGIIGFAVKQFHTAWKAKFREKLTLTGLAATHQHRVERVCQFGIAARGVVFTVIGGFLVLAGVDANPGEAKGLGEALAVVARQPAGDVLLGVVAAGLVAYAAYLFLQARYREL
>NC_017030.1|WP_014393676.1|967901_969341_-|glutamine-synthetase
MEQKPLRDFLEIPYDELEELNLKVKRQRIKRESPDKIREERIKYLTDEKRIKAVTVCFTDLEGRLHMLDYDKKFLLKSADNLTFDGSSIRGFSAQAESDLRLNVDWSAFYWLPSDIFGPGKVLAFCEVLERDGTPYHSDMRGQLKRATEQLFQKDGTVFHAAPEIEGFLFKNRDAERHYHEEGKFEFISIGGYYHALPGDGLRAFIDKAAEAQRAMGFENEKDHPEVAPSQFEMNFSYSEALVAADQIQLYKLLCRQVAAQQGLTASFLPKPVTGVNGNGMHINMSLSKNNKNLFYDKGGQDGLSAMGWEFIDRILNNANDICLVLNSSVNSYRRLDPHYEAPNQIKASANNRGAMVRIPFGNERSARVECRSVAPDANPYMVLFTLLKTGLEGPQPQEDAETKRSRTRFLPDNIYDAVRFFKGSQFIAQTLGEQVQGKYAELKVAAADRCPKQLGTRVKDAEIQFHHEVTNQYLWNLF
>NC_017030.1|WP_148282475.1|969581_970808_-|C39-family-peptidase
MLATCIWACASSPPSPSSDAPQETGSPARLWQKTSVSGDLARFSRDGTRVTADGALELDPSTAKEGTDPFPAGGWLDGGSFYNGGTFRVGTATSEVQSVPGGFDSVVPSFDAQTPPGTWVKLTVSARVEGTWTKDYELGVWAFDTTTVARHSVDNQGDADGNVLTDTLNLKRRADALRVTVHLFSERADVSPRVRALAAAVTDTRLKPQDATSDRTGWGVVLDVPGYSQMIYPDGGEVWCSPTSTTMLLGYWSRKLGRADLEHPVPTAAAHTYDWVYKGTGNWAFNTAYAASMSNGALHGLVARFDSFAPVERLVAAGIPVSISIAYEPGELPGGASRRTDGHLIVVKGFTDTGDVVGNDPAFGSNETTHATYPRAELWRAWQHSRGAAYVLWPAGTPLPEQGLVPLP
>NC_017030.1|WP_014393678.1|970983_971466_+|hypothetical-protein
MNHAPLYTVEFYEEANGSSPVFKWMTEELSPAQRRVVTAALEELVAPMGPDIAGTEFGKNLGGGVIELRLRQDAAQLLKRVGKPPREPHPEDMGEEILLRIFFHPHGRKRALVLHGYDKGRNPSMRHQQQQIAIAEARRVRFKQREKQRDKRAGKPRGGK
>NC_017030.1|WP_014393679.1|971502_971904_+|helix-turn-helix-transcriptional-regulator
MGGLVRTLKDLTAFVEKEAAAEGPAAQAELQAQRDRFRIARELAMLRKAQGLTQAQLSARAGVPQSEISKIESGKANATGLTLFRMAHAMGHVFRLEPVGSAVAPTRPRRSVAGKKGRAVRKGAPRSRELEPA
>NC_017030.1|WP_014393680.1|971918_972602_-|hypothetical-protein
MSHFFSRVLVGTTLLLAGCDSSADTDGYKQVDCSYWWSRQPLFEDLRPAAGLDAVQVRGTREQPPSEGPASGSIASWGQACSTATDVPACQAAVEAARPSEGFHSSCYADACSYHFLLTTQGDQVRTHSTPASVREVLGTIDTEQEAVLMVYAMGYDFLCYDVDQGGVKANVDGSFDVIGFRGIQCDGDIPITQHVFHVPASGEVREMESHVLQGGDETCGPPGAPP

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Crispr_ID: NC_017030_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_5

1833418-1833546

Orphan

Consensus_repeat	Method
CCAAACCTGTCCGACTGTCGGACAGGTTTCCACGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_5

>merge|NC_017030|5|1833418-1833546|CRISPRCasFinder
CCAAACCTGTCCGACTGTCGGACAGGTTTCCACGGCGCGGAGGGCGGAGGCGCGCCGCCCGCAGCGCCGGGCACCGAGGAGGCGGTGTTCCTCCAAACCTGTCCGACAGTCGGACAGGTTTCCACGGCG

>NC_017030|5|3|1833418-1833546|CRISPRCasFinder
CCAAACCTGTCCGACTGTCGGACAGGTTTCCACGGCG	CGGAGGGCGGAGGCGCGCCGCCCGCAGCGCCGGGCACCGAGGAGGCGGTGTTCCT
CCAAACCTGTCCGACAGTCGGACAGGTTTCCACGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014394375.1\|1836378_1837269_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394381.1\|1842950_1843832_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_017030.1\|WP_043321124.1\|1832107_1833295_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394374.1\|1835077_1836163_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_167594320.1\|1824397_1826716_-\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NC_017030.1\|WP_171426003.1\|1834442_1835033_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NC_017030.1\|WP_014394370.1\|1831242_1832106_+\|formyltetrahydrofolate-deformylase	unknown	unknown	gnl\|CDD\|235676
NC_017030.1\|WP_014394377.1\|1838644_1839754_-\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|274511
NC_017030.1\|WP_014394368.1\|1829866_1830253_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131637
NC_017030.1\|WP_014394376.1\|1837377_1838640_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340874
NC_017030.1\|WP_148282200.1\|1821103_1824109_-\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NC_017030.1\|WP_014394378.1\|1839792_1840956_+\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
NC_017030.1\|WP_014394379.1\|1840966_1841452_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394369.1\|1830249_1831122_-\|TIGR02587-family-membrane-protein	unknown	unknown	gnl\|CDD\|370584
NC_017030.1\|WP_014394380.1\|1841513_1842743_-\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234846
NC_017030.1\|WP_043321123.1\|1827139_1829809_-\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NC_017030.1\|WP_014394363.1\|1816930_1818106_+\|lytic-polysaccharide-monooxygenase	unknown	unknown	gnl\|CDD\|225932
NC_017030.1\|WP_014394364.1\|1818097_1821070_-\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NC_017030.1\|WP_014394362.1\|1815440_1816868_+\|DUF1552-domain-containing-protein	unknown	unknown	gnl\|CDD\|377875
NC_017030.1\|WP_014394372.1\|1833648_1834446_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014394381.1\|1842950_1843832_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.68562e-67
NC_017030.1\|WP_014394368.1\|1829866_1830253_-\|hypothetical-protein	gnl\|CDD\|131637	TIGR02588, TIGR02588, TIGR02588 family protein. The function of this protein is unknown. It is always found as part of a two-gene operon with TIGR02587, a protein that appears to span the membrane seven times. It is found in Nostoc sp. PCC 7120, Agrobacterium tumefaciens, Sinorhizobium meliloti, and Gloeobacter violaceus, so far, all of which are bacterial. [Hypothetical proteins, Conserved].	4.37556e-15
NC_017030.1\|WP_167594320.1\|1824397_1826716_-\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	1.79567e-08
NC_017030.1\|WP_014394370.1\|1831242_1832106_+\|formyltetrahydrofolate-deformylase	gnl\|CDD\|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	0
NC_017030.1\|WP_014394377.1\|1838644_1839754_-\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|274511	TIGR03300, assembly_YfgL, outer membrane assembly lipoprotein YfgL. Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking].	3.86799e-27
NC_017030.1\|WP_014394363.1\|1816930_1818106_+\|lytic-polysaccharide-monooxygenase	gnl\|CDD\|225932	COG3397, COG3397, Uncharacterized protein conserved in bacteria [Function unknown].	2.31682e-74
NC_017030.1\|WP_014394376.1\|1837377_1838640_+\|MFS-transporter	gnl\|CDD\|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.68187e-35
NC_017030.1\|WP_148282200.1\|1821103_1824109_-\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	2.35796e-07
NC_017030.1\|WP_014394378.1\|1839792_1840956_+\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	2.59127e-138
NC_017030.1\|WP_014394369.1\|1830249_1831122_-\|TIGR02587-family-membrane-protein	gnl\|CDD\|370584	pfam09622, DUF2391, Putative integral membrane protein (DUF2391). This entry is found in Nostoc sp. PCC 7120, Agrobacterium tumefaciens, Rhizobium meliloti, and Gloeobacter violaceus in a conserved two-gene neighborhood. Proteins containing this entry appear to span the membrane seven times.	4.56078e-110
NC_017030.1\|WP_014394380.1\|1841513_1842743_-\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|234846	PRK00844, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NC_017030.1\|WP_043321123.1\|1827139_1829809_-\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	1.29451e-09
NC_017030.1\|WP_014394362.1\|1815440_1816868_+\|DUF1552-domain-containing-protein	gnl\|CDD\|377875	pfam07586, HXXSHH, Protein of unknown function (DUF1552). A family of proteins identified in Rhodopirellula baltica.	3.18791e-50
NC_017030.1\|WP_014394364.1\|1818097_1821070_-\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	2.00749e-10
NC_017030.1\|WP_171426003.1\|1834442_1835033_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	5.75867e-28
NC_017030.1\|WP_014394372.1\|1833648_1834446_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.89283e-07

>NC_017030.1|WP_043321124.1|1832107_1833295_-|hypothetical-protein
MRLRIAGLVFWTALLGAACTVDDPVATLRSPDAGTDVPDEWAAHCANSGPPLLLGNPASGPQACSGQLAQTLFRRAACSCEGLSLSAPFTVDAFRSSAGPYAPGGPGGDVGVNGVLSANDRVSVGGSLQVGGVQLSSPLTVGGGLDSNGPLSGPGTSATVAGDARVNGDVGLAALTVGGVLTVPPEFSPGPAQASELRREPVPPVTPCDCDEGSRFDPAALIAHHTVDNDNAAIGLDPATLTDVSGERVLELPCGRFLLTRIAGPGHATLRIRGRTALFIPGGVDLREALTVDVQPPGELDLFLAGGFIVSGDLTLGSAALPSRVRVYVAGSQALDISAGSTLAGNLYAPQAQLNLSGNAEVFGSLFVRHLESSGAVQVHHDADVLGAGAACPAG
>NC_017030.1|WP_014394370.1|1831242_1832106_+|formyltetrahydrofolate-deformylase
MTERPAQYILTLSCPDQRGIVHAVSGWLAEHGCNILDSAQYGDPQTRLFFMRVHFTDEEGKAQPAALREAFGALAGRFSMEWKLHDAAEKPRVLLMVSKIGHCLNDLLYRYRSGILPVEIPAIVSNHRDFYQLAASHDIPFHHLPVTPENKERQEARLLELVREQRVDLVVLARYMQILSAGTCDALRGRLINIHHSFLPSFKGARPYQQAYDRGVKLIGATAHFVTGDLDEGPIIEQDVERVDHTLSPEALTAIGRDVESVVLGRAVTWFVQHRILLNGHKTVVFR
>NC_017030.1|WP_014394369.1|1830249_1831122_-|TIGR02587-family-membrane-protein
MADSLPANAPQRRRPVSDSLREYGRGIAGGLLFSLPLLYTMEVWWAGFTSHPGNVLGYLVATYVLLLGYNRYGGFRRDVYWFDVFTDSMEELGLGLLVSLGVLVLIGRIGQGTSLQEAVGMVVVEAGTVAIGVSVGTAQLGGQHREENEEEDKKRLESADHVPGQLVISFCGAVLFAANVAPTEEIVMIAVETQPWCLLGIAVLSLLLGGLILFQSDFTRAHRFTRRRLRRDVFAGTFVTYAIALLSSALVLWFFGRFTGNGLSVCVAQVVVLALASTLGASAGRLLIQS
>NC_017030.1|WP_014394368.1|1829866_1830253_-|hypothetical-protein
MKTHWNWLEGVVFIASCVLVALVMGYLAVDAWTTGSGPPDLTVQVGTPVAAVNAKEWRVPVTVTNHGDSAAAEVHVRVSLRGGREPKEEAEFVLAYVPRHSQREAWVAFRQEPSPEGVEAHAVGFATP
>NC_017030.1|WP_043321123.1|1827139_1829809_-|carboxypeptidase-regulatory-like-domain-containing-protein
MLVLGLGVAVVSFREPAGPAPASNGRLRDARPGHSGTRFTQPLAMPAEGSLRITGVVRDARGPVAGVQVSASRVDADTLSERPCPPTHPRHEHSPQRMRQGDCCFQEMALEYARLVDAREGEAPVLAQTVTEEDGTFVLEGLPSGTFTLWALGDTGAAVQPDIPAGRDDVTLTLDDGVFLSGGVVEEFTRVPIPGARVTLIHEAGSRFFDALADARGRFRVGPLPAGRYLRVASAQGYQTQAFREDVWLDADVDVTLVLHRKHRLEGVVLTPEGLPASGLDVHLALSEGEGETSTTRSDGQGRFAFEDVPALPHELWTRTGDETAYGQALGMPPEKVVLRMEPTGFMEGTVRDEQRRPLAGVRLRVKGHPLGGQPVPEVLTDAAGHYRLGPLLDRRVDLRLLLAHYADRLERLTLGAPHTGPWDFTLTRVPSVEGQVVDTEGVPLAGVQVRITMTRELPERIWDLAVVDDWSDTSDESGHFTVDSMHEGPGQLSVTARGFLAVKLPVEVPSTGVRVVMNRGASVSGAVMDATGRPVSNVDVRLWNTEPLSGDPHRASVDSRGAFTLGGLEAGHYVLEARLRTPGIEHTASQSVDLDEGTQATVSVRFEEGRTLQGMTVGGDGQPMSGVRVQACLLLEDIPAWQAHAPDCSVTGERGVLSGPDGRFVFKHLTAPAYQLIAWKEGQAFAPSRSQGGTPDNTALLVTLGQGDVRLVLERRPRLRGQVVSDDGTPLPCKVLERGDWVQALDGTFDLPLPDDGPGKLLVSAKGFFELQRKFVVSPGTDIDLGTLWMTRSRTVRFTVLSEATRVPLAGLKVAINTNADAPRPGVRGSSFYFGILDADGSAEVEGVPFESATFSVSMYGGPEQGETDGVLDATQETVTVLMPEANR
>NC_017030.1|WP_167594320.1|1824397_1826716_-|carboxypeptidase-regulatory-like-domain-containing-protein
MEAREGDAPVFAQTVTADDGTFILDGLPAGVFTLWALGDLGTAMQPEVPAGSTDVALTLEAGIFLSGTVMDEDTWTPIPGARVTAVQDAQSRFFDTLTNAQGRFRIGPVPPGQYLQVGSAQGWRTTAFREGVWFDTDVDVTLVLQKQARLEGLVLTPEGRPASGITVQAFFTGVSDDAWSTRSDAQGRFVFEDVVGAPYTVWVWAWNEAAIGDAPAKAPAQVVIRMEPVTFMEGTVRDERGRPLEGVLLEGRNLPLEAAPSLEVISDAAGHYRLGPLRQTTMNLRLRHARYSDRTETIDLRTPHTGPWDFTLQQTASVEGWVVDTEGTPRPGIRLRLAKGPVGTRERAFVDEAEALSDDAGHFILDTPKEGSGHLVIDSEDFSSMEQPVEVPSTGVRVVLSRGASVSGKVVDAKGAPLPHAEVLLWDPTALGGDKDPRSLRVDSEGTFSAAGLKAGHHILEARLRTPGIERSVTEAIELGAHSQATVSLRFEEGRTVKGLTVDTDGQPLAGVRVQACLSLEDAPEWRTRSPSCDAGSEQGVLSGPGGHFVLKHLVDPAHQIVAWKEGHAFVPSRSRGGTPGPAALVVRTGAEDVQLVLQERPRLRGQVVNEDGMPVFSEVWLGRRQKPAPDGAFALPLLEDGPGQVTVRAKGFFALERDFVVSPGKDIDLGTLVMRRSRKTRFILLDAATRTPLVGARAFIGRSECNDRSCTGRSSSSFYGNLDAEGGADVEGLPFAPIAMSVSLRPGEPTTDVLLDARQETVTVLMPDPSR
>NC_017030.1|WP_148282200.1|1821103_1824109_-|carboxypeptidase-regulatory-like-domain-containing-protein
MSASRVEPEVTLSERSCPPSEDASGEHPRRLMQCWDEAFDELVDQVDKREGEAPTVAETTSAEDGTFVLDGLPDGMVTLHATSGQNVAMRPDVMTGQQDVVLVLDEGSFFEGIVLEGPAGTEPIAGARVTVFSHEHTRFFPAISGVDGRYRIGPVPPDDYGILVTASGRGPNLRMRADPWEEDTFILDRPAKYAGTVVTAKGAPAPGVSVRLYKPSATPESRTALTDAQGRFSFPSFEDVPGQLFAETAARDGLAHLRTGPREDIVLTLGPGMVLQGHVSDENGRPIPGARVMADLDDANAPSPRGQTVTDAQGHYRLGPLFRLPHFVAVRAEHYIDDEPEHYELGEVEETLDFILPRALSVEGILVDEAGQPLAGHGVFLHPGSATSVIVDVSLESTVTDEAGRFILDSDEAGPAWLSVSDEAFVPQHFTVGRPSRDVRLVLRRGARVPITVLSAAGAPVRGARVELWKQDARGESHHAGVTDARGQVTLQGVPPGSYVAEATLARQAVDVHASQPLEVQTGEAPPVTLRLEEGRTLQGTVVNPQGRPLPGVSVRAELLDADRPRYRSAQSTGRIPEGVRTDAEGRFTLRSLSAARYTLGATLAEHRIDGALSQGVRAGEYATVIVGRDTAEVRLVLRRIPHVRGRVVAEDGAKLDLFEVNGRRYEDPQGRFDQPLPKATGPQRFVVRARGYAPVDRSVTPDGDGDVDVGTLTLTRGRTVQVFLRDAATGEPFTGRVRDDSGQWATIAIGYRIHGEGVADGPPYLPATGAVPRKDGSLLLEHLPPTAFTLEVDTQLHLPARVTVGEAEDSLTLSLDSGARVTGYVRDARGQPLGAELVFTRSDGLTLQRSLASGEFTLRAIPPGRYTVNAWRMEITSETLFPSRTVQVPPSGEVRVTFDELGTGTTVTLRLPPEVDLALLLPGQAPFPDSPRAFEHLRLQQHPVAEWTGPSVTFRRVPKGHYTVIASTRDKDRIHREELDVPAEGTLSRDVKPVWRLLAP
>NC_017030.1|WP_014394364.1|1818097_1821070_-|carboxypeptidase-regulatory-like-domain-containing-protein
MGNGGPGGLKPWLGGIALAAVALLAFLLWNTEAPSSVKDSSVPPVSSATKPAARATRVTTPPSPAGTARITGRVLGTSGPAAGVRVSASRVEPGVTLSERPCPNPSGQDDARAPALKSGTCSFDSERMQWESVEARDGEAPVFAEAATDAEGRFVLEGLPEGLVTLWALGDTGAVSQGGVAVGSNDVGLTLEQGVLFEGTVTDTDRKPPIPDARVTLVSRWHTRFFDATTDAEGRFIVGPLPQGDYAAFVTAEGRSPWFKPEVESLTDMQPVVLARALSLSGQVLSVDGAPVPGILVHLDGDTATASTQRTTTDGAGRFRFNAPAVLHQLTAEANGAFATLDVTPPQEDVEVRLQPGVFVTGTVRDDAGSPIPNARVETYREDGGPVSAEATTVTDAGGRYQLGPTRPGPHTFRILAPRYLDVELHAQKLQQGMAPLDFTLKRAKSVEGRVVDTSGAPLAGILLSLSGNRLGDGDTIDAGGARRSDATGHFILDVQRAGTGELSVEEPSFQRQSITVNIPSRDVVVVLDRGASVSGTVTDPQGLPLRGATVSLETEAQEDAPYEEPRQTLTDEQGRFHLRGIAPGTYLLGAIVRGDLMDASVSQPITFQAREHRDVSLRMEPGHERSGIAVDGAGQPLADVVITADLDEDASSEWRTVYDSGPSGLRTGPDGRFTLRGLVAPRYAVWAHLPGYTFRPGRSQGGEPIAEKDGLWVDSSEAPLQLVLERDGRIRGRVVAPGGQAVTSFQVKGADLYNSAQPDEWPDGTFELPFGMAGPATLTVEARGFMPLERAVTLSEGVDLDLGVLTLDPGWTLRLAVHDAETGEALSQLESFRATLTRPGDSDIARARSRPQNVPLRDGVYTLSQLPPPPFTLSLQSRNTRPFEQQVTAHVDTLTVALDRAATVRLLARDTNGTPLPALVSLKELGAHPMPRYQDFAPGGTLVLRGIEPGEYLLDARAADPYEGPRFTPRKVLIPPRGEVTFTVEASSP
>NC_017030.1|WP_014394363.1|1816930_1818106_+|lytic-polysaccharide-monooxygenase
MFPAIRKAFTASLAFVSLLSAGPAAAHGSMEVPLSRVYGCFKEGPESPRSAACKAAVQTGGTQALYDWNGVRQGAANGRHREIIPDGKLCSAANESHKGLDLARTDWPSTLITPDGSGRFEFVFHATAVHATGYFQLFVTKEGYNPALPLKWSDLEATPFCNVTNVSAVNNRYRLNCPFPASRTGSHVIYAIWQRADSPEAFYACTDVKFSDTPPPPVSWKELGQVQAREDLPKSSKVTFRLFDSAGRDAESYPLTLDAATPAATWMYRLAQQVNAGSSRVQVGVLQTTGSVTPVQDALGNRVYAKETGYSFQVDIEKPSTGGSAQYKYPAGIDSYTAGTLVEGTDGLIYRCKPFPYSGWCKGAASHYAPGTGMAWQDAWERANLARGASR
>NC_017030.1|WP_014394362.1|1815440_1816868_+|DUF1552-domain-containing-protein
MKLSRRRVLQGLGGVMLGLPVLEGLMPRKAQAADANALPFAIFLRQADGVAAAQNTSELGNEPERFWPEPLGNLSTTTLAGKSLVELADHRARLLVVRNVNMKDYNYGDGHARGALQCLTARGPAVEGVGGDSEASGESLDHRIGRELNPQKRDSLYLYAGQAGGWLGGPCISHRGSASRRAALHDPWVAYQTMVGGPGGLSPEAREQLLVRQKSLNDLVSGQLKALQSRPELSGTDRQRLDLHLSNVRDLEVALSCRARADEELRLQQQAPGYNSTDGDEVLATVRLHMDIAVLAVACGTTRSVAIQVGNGNDSATRYRDPTTGQLMENFHYISHRRSSHDASGGIIAGSDVLHSRVDAQFAQTFNYLLDQLAAYTLPDGKKLVDQGVSVWFNDLGNGPAHSARHIPFILAGSCNGYLKQGVAVTAAGGNSSPNLNKMLNTIGAAVGLKNAAGGPLDDFGDPSLPKGLLTELLA
>NC_017030.1|WP_014394372.1|1833648_1834446_-|tetratricopeptide-repeat-protein
MSARPPDDGDGEPLDDLLRPLDNGSGPARRLSRQRSSALVQAALDAALQQAPEPPRRRRRPPVWLMAGAALVFTGAAAAAWRYARPSQPHPQVLTPAVPEPTRMATLEPVPLPPPAPSEPFVIEHPRPLRPSITVKESSKPEDLLRQANALRSAGKWKDAEGLYLRVIRAEPSSLAAYVARVASGALRLEHLGDARGALRQYQDAVRLQPGGMLDPEARHGVAEAHRALGDTAAEARALGEFLSLHPDSPLSAASRARLRELSPP
>NC_017030.1|WP_171426003.1|1834442_1835033_-|sigma-70-family-RNA-polymerase-sigma-factor
MRSSGSHATVAPRGEDARLTAAMRGQRDATEALLLELLPRVRNLVRYLVRGDSDVEDIAQESLIALVRGLPTYRGDGRFHGWVDRVVVRTTFAWLKRSRGREARYSGDPVELLAVPSDEAPADEYLHRRHLVTLLDRLSTEQRHALVLHHVLELSVQEISTELGVPFETVRSRLRLGRTALRALASDGEAPEGESS
>NC_017030.1|WP_014394374.1|1835077_1836163_-|hypothetical-protein
MSVLEAVARQRVVVLALVLGLWSPAWAAEPWRAVARVATSEDRSLLERVRGQSSDLPVILEAEAGPSMDASPGGAWREAERLASRKDARAVLWFTRDAAQLRVSVAAPRTGHLFVRSARVEGAPETLTWSVGAEALALAVRSALRAVDAGEPLGDVVAPPPPPPVVAAPPDLPAAADPGVEAPVTPVDGAFFQVGVHAALDGYHSWGQQGLSVGAGWAGRVLRLRAQVLAALPVHLRDAYADIRLTQGSALAWADVPFVKTGTWEGTVGLGAGVAGFWRRTEARAPDVEPTPSRLLAAFVVGPAVRVAWRVGPALALEAALSGEVLLGRPRLGYAAEGGFVLREDGASVRPRLGVGMVIFP
>NC_017030.1|WP_014394375.1|1836378_1837269_-|hypothetical-protein
MYTHAVLVPFKVNPKDEGHADVLSIAKGLHERIRKHPYKIQNKTRRLYKQILRLGEDREDLMLSKVPFDSTRSTLYVTAHGNADEIGTRGPVSISPERLARKLAEAGMPKTLTDLKVMTCNSGFGWKKYGYLGPANTENLLDEEPQGTTVTTVDEEPQQEGSAPFTIPTGESSASFIPEQKQETEDLPATEEQEQDTEVVPDEVKEDKMMHPAKPKKLTFYVRRLCIALYKRGYTNLRVHGYVGFTGEVKKKGENHTFVTETYGGSRLIRASLSRVTVQGEFGWTVQKPKLRLKVK
>NC_017030.1|WP_014394376.1|1837377_1838640_+|MFS-transporter
MNRLRELRSVLNLTVLVAGLGYFVDLFDITLFGVVRVASLKDLGLTDPSDIFQKGLFIYNAQMAGMMVGGLFWGLLGDKRGRLSVMFGSILLYSAANLLNPFVWDVNSYAACRFLGGLGLAGELGAAITLVAESLPKEKRGLGTTVVATLGMLGIVVAALVAQYLHWKAAYVTGGVLGLLLLFARFKVSESALFTQKGGPERGNPLLLLTGGRFTKYLGCILVGVPIYFTTGILFVFAPELTAGLHVQGTVTAGNAILFGSVGLTLGDLSSGLLSQWLQSRKRAVGFSLCAWFALVLVYGLMPGLTPTLIYALTFLIGLTVGYWAVLITMAAEQFGTNIRATVATSVPNFVRGSAVIAATAFGQLKGSLGVAHAALAVGAVCFVLALVALARLAETFHRDLDYVESANPASADAPTGSGA
>NC_017030.1|WP_014394377.1|1838644_1839754_-|PQQ-binding-like-beta-propeller-repeat-protein
MPSRACPRLPLVSCLMLTLAVMACQRAPVEPAFQYSSDASSRTGLTALSDGVLLGNEAGAVVRLDREGRPVWTTRLGREVAVPPALAGESVVVGTVVGEVACLSLKDGKERWRLGGEPPVLTPPVVDDAGHTVFLVAPDGAVRALAVDSGQERWRRPAPKASAPVESLEPQVSVAPGLRAAPVLVADVLVVPLGAGLWALDAGSGEPRWSRPVTDVVGLDSERDTVFVATRPGRVLALSVKDGSTRWEQRLADGVTGPPARALGALWVGAGPSSLVGLSTAEGREVARVELPTPLVGRVQVGLEDLLLVPTSGHAGNLVALKAPGWTTAFTVRADTPLRTRPVVRGPLVFVLGLDGRVLAWRLRVPPPN
>NC_017030.1|WP_014394378.1|1839792_1840956_+|adenosine-deaminase
MPTIRDDETPNATGIPSSARRTDITPPPTLAVTEELLHALPKTDLHCHLDGSMRLKTILELAEQQKIKLMADTEDGLAKAIHMGQVCKSLEEYLVAFDVTLSVLQTAESLYRAAYELAVDAAAENVRWLEVRYSPALHLQKGLKMTTVIDSVLEGLRAAKKETGIKCAVIVCGIRHINPQTSMRLAELSVAYKNRGVVGFDLAGAEASFPAKDHLDAFRLILKNNVNCTAHAGEAFGPESISQAIHSLGAHRIGHGTRLREDGDLLNYVNDHRIPMEVCPSSNVQTGAVSSLESHPLKFYFDYGLRVTINTDNRLITDTTVTKELWLAHRNLGLSLEDLTTIIVSGFKSSFLPFREKQDMLRQVNQEIATTLAAFEKRPVAAMRQPA
>NC_017030.1|WP_014394379.1|1840966_1841452_+|hypothetical-protein
MDDTQGLPPPDFDPARAKAAQDLKLPALIMMGMGGLWVLYSLFGLYRTLSPAGMEQLHAGIEKALEVYPPELRVQARSILSHFLSPAFLAVSALPGICLNGLVVFGAWKMKNLQLHGLAMTVSIICCIPCCGPGWGLGLIPGIWSLVVLNRPEVKAAFRSK
>NC_017030.1|WP_014394380.1|1841513_1842743_-|glucose-1-phosphate-adenylyltransferase
MSKLLAMILAGGAGTRLEPLTRERAKPAVPFGGRYRIIDFVLSNFANSGVYRMKVLTQYKSDSLNNHLSRAWRMTAFLGHYVEAVPAQMRTGVDWYKGSADAIYQNLNIITDEEPDHIFVFGADHVYRMDVRKMLDFHIAQKAACTVAAIPVPIEQGREFGIIDVGPDGRMLQFLEKPKDPPPMPGNPKMCLASMGNYLFTTDTLVKQVVRDAADEKSAHDFGKSIISELYKHEPVYVYDFAQNTVAGQEDKERGYWRDVGNIDVYYQSNMDLVEVDPTFNLYNDRWPIHTQPNNFPPAKFVFADRESKRVGTATDSLVAEGCIISGGHVHRSVLSPKVRVNSYSEVEDSILFENVTIGRRCRIKRAIIDKNVEIPPGMTIGYDPVEDKRRFHVTSGGVVVIPKGMKVT
>NC_017030.1|WP_014394381.1|1842950_1843832_+|GGDEF-domain-containing-protein
MSGDQTRVTKISSLTPGPERGTECCLVQIHGPELGKKYVLEETEFTIGRDQHNHIVVDLDNVSRRHARIWTRQGKTFVEDLQSTNGTYLNDREVLQAQPLRSGDLVKVGGSIFKFLDGDNIETQYHETIYTLTIADGLTGINNKRYFLEYLEREMGRSHRYQRTLSLMMFDIDHFKQINDVHGHLAGDYVLREMAQSIKRLVRREQCFARYGGEEFAIVMPEDGPDKARLFAEKIRKLVEDKRFVFEDKDIPVTISIGVAEVASEMSEPSQFIKVADANLYKAKKSGRNRVVG

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Crispr_ID: NC_017030_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_6

1928589-1928665

Orphan

Consensus_repeat	Method
AACCTGTCCGACAGTCGGACAGGTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_6

>merge|NC_017030|6|1928589-1928665|CRISPRCasFinder
AACCTGTCCGACAGTCGGACAGGTTTTCGCCGCATGAAACCTCAGGCCACGAACCTGTCCGACAGTCGGACAGGTTT

>NC_017030|6|4|1928589-1928665|CRISPRCasFinder
AACCTGTCCGACAGTCGGACAGGTTT	TCGCCGCATGAAACCTCAGGCCACG
AACCTGTCCGACAGTCGGACAGGTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014394456.1\|1929577_1930564_-\|Prolyl-tri/tetrapeptidyl-aminopeptidase	unknown	unknown	gnl\|CDD\|283275
NC_017030.1\|WP_014394448.1\|1920564_1921896_-\|AHH-domain-containing-protein	unknown	unknown	gnl\|CDD\|379603
NC_017030.1\|WP_014394461.1\|1936095_1936899_+\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NC_017030.1\|WP_014394455.1\|1928824_1929541_-\|Prolyl-tri/tetrapeptidyl-aminopeptidase	unknown	unknown	gnl\|CDD\|283275
NC_017030.1\|WP_014394459.1\|1934241_1934658_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394450.1\|1923409_1924783_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NC_017030.1\|WP_014394447.1\|1919980_1920553_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394457.1\|1930725_1932912_+\|peptidase	unknown	unknown	gnl\|CDD\|367566
NC_017030.1\|WP_014394451.1\|1924792_1925095_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394460.1\|1934668_1935958_-\|threonine/serine-exporter-family-protein	unknown	unknown	gnl\|CDD\|377697
NC_017030.1\|WP_014394454.1\|1927763_1928384_+\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|239344
NC_017030.1\|WP_014394452.1\|1925287_1925761_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|224159
NC_017030.1\|WP_014394463.1\|1938997_1940938_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014394449.1\|1921903_1923220_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394446.1\|1918598_1919930_-\|AHH-domain-containing-protein	unknown	unknown	gnl\|CDD\|379603
NC_017030.1\|WP_014394445.1\|1918011_1918587_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394458.1\|1932928_1934104_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NC_017030.1\|WP_085960292.1\|1926117_1927662_+\|lamin-tail-domain-containing-protein	unknown	unknown	gnl\|CDD\|376421
NC_017030.1\|WP_014394462.1\|1936895_1938938_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014394464.1\|1941039_1942644_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014394456.1\|1929577_1930564_-\|Prolyl-tri/tetrapeptidyl-aminopeptidase	gnl\|CDD\|283275	pfam05576, Peptidase_S37, PS-10 peptidase S37. These serine proteases have been found in Streptomyces species.	4.75589e-54
NC_017030.1\|WP_014394448.1\|1920564_1921896_-\|AHH-domain-containing-protein	gnl\|CDD\|379603	pfam14412, AHH, A nuclease family of the HNH/ENDO VII superfamily with conserved AHH. AHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif, AHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and LHH, the AHH nuclease contains 4 conserved histidines of which, the first one is predicted to bind a metal-ion and the other three ones are involved in activation of a water molecule for hydrolysis.	4.19478e-30
NC_017030.1\|WP_014394461.1\|1936095_1936899_+\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	1.25203e-67
NC_017030.1\|WP_014394455.1\|1928824_1929541_-\|Prolyl-tri/tetrapeptidyl-aminopeptidase	gnl\|CDD\|283275	pfam05576, Peptidase_S37, PS-10 peptidase S37. These serine proteases have been found in Streptomyces species.	4.51013e-35
NC_017030.1\|WP_014394450.1\|1923409_1924783_+\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	2.03197e-73
NC_017030.1\|WP_014394457.1\|1930725_1932912_+\|peptidase	gnl\|CDD\|367566	pfam03571, Peptidase_M49, Peptidase family M49.	7.9988e-46
NC_017030.1\|WP_014394460.1\|1934668_1935958_-\|threonine/serine-exporter-family-protein	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	2.9892e-60
NC_017030.1\|WP_014394454.1\|1927763_1928384_+\|glutathione-S-transferase	gnl\|CDD\|239344	cd03046, GST_N_GTT1_like, GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal TRX-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GTT1, a homodimer, exhibits GST activity with standard substrates and associates with the endoplasmic reticulum. Its expression is induced after diauxic shift and remains high throughout the stationary phase. S. pombe GST-III is implicated in the detoxification of various metals.	9.1449e-35
NC_017030.1\|WP_014394452.1\|1925287_1925761_+\|DedA-family-protein	gnl\|CDD\|224159	COG1238, COG1238, Predicted membrane protein [Function unknown].	6.78378e-23
NC_017030.1\|WP_014394463.1\|1938997_1940938_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.64375e-88
NC_017030.1\|WP_014394446.1\|1918598_1919930_-\|AHH-domain-containing-protein	gnl\|CDD\|379603	pfam14412, AHH, A nuclease family of the HNH/ENDO VII superfamily with conserved AHH. AHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif, AHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and LHH, the AHH nuclease contains 4 conserved histidines of which, the first one is predicted to bind a metal-ion and the other three ones are involved in activation of a water molecule for hydrolysis.	1.39165e-28
NC_017030.1\|WP_014394458.1\|1932928_1934104_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	4.1992e-43
NC_017030.1\|WP_085960292.1\|1926117_1927662_+\|lamin-tail-domain-containing-protein	gnl\|CDD\|376421	pfam00932, LTD, Lamin Tail Domain. The lamin-tail domain (LTD), which has an immunoglobulin (Ig) fold, is found in Nuclear Lamins, Chlo1887 from Chloroflexus, and several bacterial proteins where it occurs with membrane associated hydrolases of the metallo-beta-lactamase,synaptojanin, and calcineurin-like phosphoesterase superfamilies.	3.3965e-21
NC_017030.1\|WP_014394462.1\|1936895_1938938_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.02993e-90
NC_017030.1\|WP_014394464.1\|1941039_1942644_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.49081e-87

>NC_017030.1|WP_014394454.1|1927763_1928384_+|glutathione-S-transferase
MLKVHHLSESRSQRILWLLEELGLDYEVVRYERDPKTGFAPPELKAIHPLGKSPLVEDGGRVLAESGAIIETLIRKYGQGRLSPAPEDLDRYTHFLHYAEGSAMLPIVQLLYVKRLGDAAAPIKPRIDSELKSHLSYLEGSLQGREYLVGNALTGADIQLSFVLEAAKSFRLLAELPNFTAYLDRLHARPAYQRALERGGPYKMGR
>NC_017030.1|WP_085960292.1|1926117_1927662_+|lamin-tail-domain-containing-protein
MAANLSSGTGQDYDPGHGIRIFQGTDADVVMIQEFNYKTDSAADLRSFVDTAFGTGFSYYRESGAQIPNGIISRYPIIAAGEWDDTQVSNRDFAWARIDIPGPKDLWAISVHLLTTSSSVRNTEASNLVKFINANVPASDYLVIGGDFNTGSRSESTFSTFSSVVSTASPYPADKNGNTNTNAGRNSPYDHVLVDNDLRAYQTSVVMGSSTFANGLVVDTRVYSPLSDISPALSGDSGASGMQHMGVIKDFLIPGDGATASTVTVLSPNGGESWTAGSARTITWTASGVSNVKVEYSLNGSTWTTITSSTGASAGSVAWTVPSSASTNAWVRVSDASNATVTDLSNAAFTITTGGTTGTGNVFINEVLINEPGSDVNGEFVELVNSGTAAVDLSGWTVSDGTAVRHTFASGTTVAAGKAVVVFGGASGIPAGTPGAVAASTGSLVLGNSGDTVTVKNSAGTVVDTATFASSLAGTDGVSANRSPDASSTGSFVLHTGVSSLSSSPGKRASGAAF
>NC_017030.1|WP_014394452.1|1925287_1925761_+|DedA-family-protein
MPAEPSTLSTWGLPGMFFVAMLAGSVVPVPSEAMLAALIYNGTPPVMATVVATVGNVLGAVTLYILGKWVSQGGGGAVGRWVARRREKEGPRMARVEANLRTWGAPALLMAWLPILGDAFVLAGGFVGVRPLPFVVFVTLGKGLRYAFVALSTTAAM
>NC_017030.1|WP_014394451.1|1924792_1925095_-|hypothetical-protein
MRSIDTEDERIASLLVAEPPALHFEGSRNLVVRLRDGRTFVLTVLTLEALEARLGGAPSYVASGIVLVRRLSDGALLHAVRSAMDQGLEHFGTLQPPIEE
>NC_017030.1|WP_014394450.1|1923409_1924783_+|amidohydrolase-family-protein
MRSRYLTAALLALALPLSASTAPAASRTVVFQGGTVLDGSGGQPLEEAAVVVRDGKIVSVGLAIHVKVPKGAEVIDFKGQTLLPGLISDHSHVGQTSGTTTGSQNYTRENVEKQLRQFAAYGVTTVTALGMNRPLFNELRKEAHADTFTGADLFGAGQGIGVPEGGPPQAMTNSAPDQLFRPTTAEEARAAVRTLAKNRVDLVKVWVDTFLGKLPKMKPDIYKAVIDESHKQGLRVAAHIHDLEDAKAVVDAGVDIIAHGVRDQPVDAAFIQAMKKRGVWYVPTLELDEATVVYADQPLLVDDPVLQPALSPELRAQFNDSAWRKKTLEDPKAQEARHALSTNQANLKALYDAGVKVGFGTDSGATPLRIPGYAEHRELKLMVGAGLTPGQALAVATGNAADLLKLKDRGRIKPGLRADFFLVEGDPTASIIAADRITGVWRQGRKVAGKLTAPPAP
>NC_017030.1|WP_014394449.1|1921903_1923220_-|hypothetical-protein
MDEPGLQYPGEALRGWLRQFAKTPLAEPTLKLLVVLADTVFFASLGREEGEATRVRIAYHAQGLQGLQAVRETVYIGGQKGKRQAWETLPLEAKSSITDFSVEALVKLAPAANLPRTAVVVGPREGKLRIQGLARRVEYTEFHAEGEEDVFILHAPEPGHLVVSTQGREVFRYEQGAPVPPGRRVALHDLLFHEDSAVRAALMEMCSSLVESLPKVQPLMGGNREWYVSNAVQGLIRRMAGLHHGGLIAFLPKQHDVERFRARGKYVLPPEQGSLLRQRLQRFVQARADLINGAWQAEAGKAAEEEEDPELKKAAAEHDDKATESDFQALVESIGQFTAVDNALVLGPELEVLCAGYQIALPRSGPPQVFEARTLQGRPGPHYPIHQHGSRHRAAAVFANQHSGAIVFVASQDGPLRCLHRPPGKKKVLLWSLLLTED
>NC_017030.1|WP_014394448.1|1920564_1921896_-|AHH-domain-containing-protein
MKRLGWVLLLGLLVSGCATTRVVRLEVDGGDRVVVTPREEEGASHSEARLEEDEFKAAVKTLARDVRPFAHPLRQARELFGLPERSGLFGFRERSRQIIPLGEEEVRELRLLDASDDLTRGYQQWCGKKRKQPGDCLRLLEEGPLLGSDGRYALAMAIAMDSGWNETAEALEGMASPQAVMATMTSAVTMYLLLWAMPEPVSKGLAALITATAIAYLGVDTVWTLLDGWVTLVRHVDHATTFLQVRDAGEAYGAVMGRNAARIFVMLATAAIGNTAGLAMKAPTLPGSAQAAVAVETQAGLQFVSLAGVRSVAMTADGFTIALAPNAVAMSSRSGKPQRHHLATIRNEKSSKTGGPWTPLFRRIFKRAGMELKDPENIIEVPGHRGPHPRAYHERIYNRLDEATQGCRSVEACREALTQELRALANEAVTQGSILNRLLTQGR
>NC_017030.1|WP_014394447.1|1919980_1920553_-|hypothetical-protein
MVKRYFDLSEDVEAPGRWYLGDPVDENGVELEDPWMFRAGKPVQVKTPLRLPIDEPGRPLDFSAAGVGRAPILHVKLATLFAELAPHDVQLLPVDIPGQPEQFSMLVATRMIRCIDERASEEARRWEPKDGRPEKVGQYRSVYGMRIDPTQVGDAKVFRTWGWSIALIVSEDLKTALERSRATGMYFTEV
>NC_017030.1|WP_014394446.1|1918598_1919930_-|AHH-domain-containing-protein
MSRLGWALLLGLLVSGCATTRVVRLEVDGGDRVVVTPREEEGASHSEARLEEDEFKAAVKTLARDVRPFAHPLRQARELFGLPERSGLFGFRERSRQIIPLGEEEARELRLLDASDDLTRGYQQWCGKKRKQPGDCLRLLEEGPLLGSDGRYALAMAIAMDSVWNETAEALEGMASPQAVMATMTSAVTMYLLLWAMPEPVSKGLAALITATAIAYLGVDTVWTLLDGWVTLVRHVDHATTFVQVRDAGEAYGAVMGRNAARIFVMLATAAIGNTAGLAMKAPTLPGSAQAAVAVETQAGLQFVSLAGVRSVAMTADGFTIALAPNAVAMSSRSGKPQRHHLATIRNEKSSKTGGPWTPLFRRIFKRAGMELKDPENIVEVPGHRGPHPAEYHQLVYDRLRQVTSDCRSVEACREALTDALRILGEQARTHGTELNRLLTRGR
>NC_017030.1|WP_014394445.1|1918011_1918587_-|hypothetical-protein
MTTRYFRLTEDVYAQGRWYLGDPVDEKSTGVEDPWMFSAGRPIQAPGSLQVPIDEPGRPLDYSEAGVGSTPILHVKLATVFAELAPDDVQLFTVAIPGHPEQFNMLVATRLIRCIDDEASREVEYWDPIKHKQPEKAGQYYSVAGMRIDASKVGHARVFRTWGWKIALIVSEDIKTALERTGATGMYFTEV
>NC_017030.1|WP_014394455.1|1928824_1929541_-|Prolyl-tri/tetrapeptidyl-aminopeptidase
MLSLVDAYAARYDLTYSQLGRELALEHAVIETYFAFWQYRTASSCTSSIPPNTATDQQLFDAMNAVVGIDSFSDQGLAPYAAYYYQAAAELGWPQPYEKHLGALIHFPDTDTGEVYSPPGIPFEFRPSAMPDIQDWVSSQGQRLMFIYGSYDPWTAAAYVLGNSQDSYLYTVAGGNHGARISQLPAAQQAEAKATLNRWMGIAPLKRAPRFVQSEEPPVFGPHVPPHLREASSQAVRQ
>NC_017030.1|WP_014394456.1|1929577_1930564_-|Prolyl-tri/tetrapeptidyl-aminopeptidase
MARAVRFPRLLLALPLLALLGGPVACGDDEPDDPRPDSGTQPVDGGSDAGSDAGANTDAGTDEDAGSDAGSEVDAGTDADAGTETDAGTDADAGSEVDAGTDADAGTDGGVVACTPSGWVDTPPDLSVISDTSLDIAVRLEAIPGLTVKENPNGVNVPAGYRFFDLNYNQPADHAHPECQRFEQRVTLLHKADTSPMVLYASGYQVATGVGRSEPQQLLSANQLSVEHRFFDSSTPSPADWSHLTIRQSADDFHRLTQALKPIYTGKWVSTGGSKGGETVVFFRRFHPDDVDATVAYVAPIAKRNDERFVTFQDIVGGDAQRACRERL
>NC_017030.1|WP_014394457.1|1930725_1932912_+|peptidase
MKPLLLAAVLAAAPATPQKSPAPDAGLAQAAQPSLTVPGGKFLRARSGNTAVAQMFAPGIAELSLAEKRVAWSLTLAAHAGEDIALDQLGWKLVPTKQLLEGVWLFGRDAQSAASGFDGKLADYLLRFYGHGGNHDSTTGQKFVPAFTAEQLAAGASRALKAGAPWTVKDEAALQAWLQDLKPTLFDASFEPQLTSKAPPPGQDLLTASSNTAYGPGVTQKDLVGFTEKYPLNSRVVKENGKLVEQVFRAGTPDGKVKPGLYAKELSRVIAHLQEAMKSAEPAQKAALGKLVRYFQTGSPKDWDAYNIAWLKVDPKVDANLGFIETYVDPRGHKGQWEGLVNYRDTAENQIMVLMGQKAQYFEDRLPWPEKYRRKKVSLPVAKAINLITSHPEPPAGINLPNEQHIREKYGSKSVMITNVMDAASAVTRLPLALEFSRTAEDREQAQKYSVTARKWLVAFHEVLGHASGQVDPKLKGQSPSVFLKEYDNTLEEARADLVALWHAFDPALAELSPDHEAIARQMYRDFLVEGLTNLRRVETGNAFEEDHQRGHHMTVTFLEEKGVVKQVTENGRTYLTIPDYAKMREAVGELLSQLMVIKATGDYEGIRALVQEKGIHFDPKLRDEVARRVKAVDVPTVLLLNSPRVVPVLDAKGTLVDLKEDTTQAFVDQHLERSLLGRLSPSEASRVAAKVAGSPDAVREAFKELGPDTAPAPTPAKKGAAPVKSTP
>NC_017030.1|WP_014394458.1|1932928_1934104_-|AI-2E-family-transporter
MASDQVSRRVFVGLILLSIVLLCLVIRPFAEAFFLAAVLAGTFYGLHTRLKKRLRGHGNVSSGLIVTGILLALLLPLGGLTAFVVAEVSEGARFVTQTVQKGGMKGLVDKLPSGIQGPVSKLIERLPLEQAELDQKLQEQMTTQGGTAAKAVTGAVAATGTIILQLAMMLIALFFFLTDGARLVQWIESVSPLRHGQTRELLREFKSTSVSVLVSTVATAGVQAAVALIGFLIVGVPAPLFFAGLTFFLALIPAVGAAVVVLFAAGLMFLSGHPWAALFLAIWGVVVVGLVDNVVKPLLARKGMNQHGAIVFFALLGGLAAFGAVGLLLGPLIVAFFLSVVRIYERDYGRPNGRMGDPATPGGPIQPGSQRVVLTTESGTPLSDADAPSNH
>NC_017030.1|WP_014394459.1|1934241_1934658_+|hypothetical-protein
MPPFDSARFTLWLPQLLCAAFLAILFLQSGLDKVVDWKGNLGWLTGHFARSPLKGVVTPMLAVITLMELAAGALSGAGAVALLVNGNPFLAYLGAVLSALSLLALFFGQRMAKEYAGAAVLVPYFIVALAGVYLMRLA
>NC_017030.1|WP_014394460.1|1934668_1935958_-|threonine/serine-exporter-family-protein
MCAPAVSTRPSETPEAPPEFVASLAPPPPGPAVAFVLRLGHALHRHGTPAHRLEGLMKRVSERLGLEARFFSTPTSIFASFGPPEDLRTSLIRVEPGDMDLERLILLDMLADDVIHGRLTPAEGARRVEDILARPARYGPALQLLCWMLAGASAALLFGGGWKEMGVAGVSSLAIGVLDLLTRKQPTTARVLEPVAAVLSAAFAGLAAHFFGPLHGEVATLAGLIVLLPGLTLTIAVNEVATRNLISGTSRLTHAALIFLQLGFGAALGSRVATVLPPVPMPTPALPTVLPPGVALVALVVAGFAIAVLFRARPRDWGWIALAGAAAFMGARLGALLLGPQLGAFAGALLLGIGSNALARLRNRPAVTTVVPGLMLLVPGSVGFRSLASLLERDVVAGVDTAFSMLMVAVALAAGLLSANAIMPSRKVL
>NC_017030.1|WP_014394461.1|1936095_1936899_+|rRNA-pseudouridine-synthase
MARKQRTPRWLEAARRRGPEAPAGPGADWLTRALGRAGVLPRAEAEQAIRDGRVEVDGRVEREPFAPVGEGTRVRVDGVERALTRQVRVLMFHKTSGPVVHGSDPEGVGTVFERLRAVLPPELQGFEWYAVGRLDRDTTGLLLFTNDEQLVRHSTAPETHLPKRYVARVEGQPPEPALARLREGLMLEDGPTRPAEAVLRAPDVVALTLTEGRHHQVKRMLAAVGHPVLALHREAVGQVVLDVAEGAWRELSGAEVAQGLGFQPGAD
>NC_017030.1|WP_014394462.1|1936895_1938938_-|serine/threonine-protein-kinase
MALQAGDAFGRYELVSWLGQGGMAETWRAQLVGDAGVTKPVLIKKVLPEYANDEAFISMFISEARISATLSHGNVAQVFDFGRVDGGYFLAMEFVDGQPLHRFLKRAMKSGMGALPVPIAVFIAMEMCRGLHYAHTRTDSSGQPLGIVHRDISPDNVLVSYEGQVKIVDFGIAKAQLIRDLKTEPGVVKGKYLFFSPEQARGEEVDARTDIWATGVVLYELLCGKLPLDGPPEAVMMRIARGELPPLSESRPDLPAALQRIVLKALHPEQSQRFESSHAFAEALSGFLYANHPGVSSLSLAHLLRMLFRDDLLSHGRELSVPPTFQQELESWREQEPALPKKPARPRPLLHTGRIPLPESSVEIVEEEAPAALAPSASRKWMLGLSTTGLAVGASCFWLLSSPGAPPEPPGVVRPIERPAAAVQSLSDTARPPTLAATPVLQAAGSAPLTVEPIPEPALSLADYQDRVQARVQQGGLQDAVDLAHQCETRFPREGECQLLLGMLYSRINDSRSSVTHYQRFLEYAPDTHPSRAKVVRILDDAKALSSASGRIVKPETFADMIETGRTAFRDEKYPEAAAAYRNALAMKPDSFDTKLELGLTLIKLKPGTAKDHKQAVKLLEDVTRNNPSLRRAWLGLETAYTLTGNKAKAKKAHDRYMVMSPRNMANPAKAREMLKNLGR
>NC_017030.1|WP_014394463.1|1938997_1940938_-|protein-kinase
MALQAGDIFGRYELVSWLGRGGMAETWRAQLVGDAGVTKPVLIKKVLPEYANDEAFISMFISEARISATLSHGNVAQVFDFGRVDGEYFLAMEFVDGQPLHRVLKRALKSDLGALPIPVAVFIAMEMCRGLHYAHTRMDNSGRPLGIVHRDISPDNVLLGYEGQVKIVDFGIAKAQLIRGFKTAPGVVKGKYLFFSPEQARGEDVDARTDVWATGVVLYELLCGKLPVEGPPHVVMMRVGRGEIPAPSVLRPDLPKELNDIVMKALTPDREQRFESSHAFGDALAGFLYSNFPRFSSMTIAHLLRVLFRGDLAQEGREMSVPGSFLEELKSWRQQTAPEEPVTPRPSTERQTRRVRPVSPHVTETTQPRSIVASSGTSRPLLYGLSAGGLLVVGASLWLLLDAHSPSTAGGAPPPTPIRAPITVEASSLPATAESPPAPRVELAQALPPPVEDAQLHAPDVPAPETREPPRISAKEAADVKKMKVGVARAIRLKQHPDAVYLSNHCVEMYPTNADCHALVQLVGEKLFNDPPRPKTDSPTRLTTEADIQRAMTSAASIANSITDIMAHVHMLSRAGHSDKGLEVAQNCAAKAPKLPECQLMLGVLYVKIGDFRKSTEAYERFLTLAPPDHPRRARVVEILNQASRQ
>NC_017030.1|WP_014394464.1|1941039_1942644_-|serine/threonine-protein-kinase
MDLQAGDVFGRYELVSWLGRGGMAETWHAQLVGDAGVTKPVLIKKVLPEYANDEAFISMFISEARISATLSHGNVAQVFDFGRVEGEYFLAMEFVDGQPLHRVLKRALRSDLGRMPIPIAVFIAMEMCRGLHYAHTRTDGSGRPLGIVHRDISPDNVLLGYEGQVKIVDFGIAKAQLIRGISTEPGVVKGKFHFFSPEQARGEGVDARTDVWSTGVVLYELLCGKLPVEGPPAVVLSRVGNGEIPSPATLRPDLPKELNDIVMKALTPDRQRRFDSSHAFGDALTAFLYANFPRFSSMSLAHLLRVLFKEDLAQLGREPSVPGSFLEDLKAWSKPAAPARPVTPPAPPPVLQRQPRPVRPSNPTATAMPAPRVPAPAPAPPKPLRTGLGVGALLAVAAGLVFLWRHQTATQPVEEPPPQPMATLEPPSEPAPTPVAEVAPPPAAPSNEIMELRQQIQALVDEKNYDVALVKAQLCIKLDPTFPDCERYLGFLYAELGDATLSEEHYKAYVKLAAEGDPARARVMEGLGKSGDAG

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Crispr_ID: NC_017030_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_7

2005074-2005278

Orphan

Consensus_repeat	Method
GTGGGCGAGGGGCCCGAAGCCGGTGCGGACGTCGAAGCGGTCACCGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_7

>merge|NC_017030|7|2005074-2005278|CRISPRCasFinder
GTGGGCAAGAGGCCCGAAGCCGGTGCGGACGTCGAAGCGGTCACCGCGTGCGGCGTCGCCACGGAGGTCGCAAGCGAAGTGGGCGAGGGGCCCGAAGCCGGTGCGGACGTCGAAGCGGTCACCGCGCGCGGCGTCGCCACGGAGGTCGCAAGCGAGGTGGGCAAGGGGCCCGAAGCCGGTGCGGACGTCGAAGCGGTCACCGCGC

>NC_017030|7|5|2005074-2005278|CRISPRCasFinder
GTGGGCAAGAGGCCCGAAGCCGGTGCGGACGTCGAAGCGGTCACCGCGT	GCGGCGTCGCCACGGAGGTCGCAAGCGAAGTGGGCGAGGGGCCCGAAGCCGGTGCGGACGTCGAAGCGGTCACCGCGCGCGGCGTCGCCACGGAGGTCGCAAGCGAG
GTGGGCAAGGGGCCCGAAGCCGGTGCGGACGTCGAAGCGGTCACCGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014394532.1\|2018494_2019616_+\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187566
NC_017030.1\|WP_014394525.1\|2007989_2009183_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|153418
NC_017030.1\|WP_014394523.1\|2006499_2006886_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NC_017030.1\|WP_014394524.1\|2007079_2007967_+\|beta-xylosidase	unknown	unknown	gnl\|CDD\|226190
NC_017030.1\|WP_148282502.1\|2014583_2015534_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176230
NC_017030.1\|WP_014394518.1\|2001831_2002248_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394530.1\|2015530_2016529_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_017030.1\|WP_014394520.1\|2002900_2003254_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394513.1\|1997734_1998676_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187551
NC_017030.1\|WP_014394519.1\|2002294_2002783_-\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176868
NC_017030.1\|WP_014394527.1\|2011754_2012312_-\|dual-specificity-protein-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|350348
NC_017030.1\|WP_014394516.1\|2000221_2000611_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NC_017030.1\|WP_014394521.1\|2003377_2004253_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_193352532.1\|1998672_1999491_-\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|153249
NC_017030.1\|WP_043321140.1\|2016574_2018374_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_017030.1\|WP_014394515.1\|1999593_2000211_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394517.1\|2001027_2001810_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|163708
NC_017030.1\|WP_014394526.1\|2009915_2011748_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394512.1\|1996515_1997745_-\|tetracycline-resistance-MFS-efflux-pump	unknown	unknown	gnl\|CDD\|340888
NC_017030.1\|WP_014394528.1\|2012442_2014125_+\|DUF5060-domain-containing-protein	unknown	unknown	gnl\|CDD\|379863

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014394532.1\|2018494_2019616_+\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187566	cd05256, UDP_AE_SDR_e, UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs. This subgroup contains UDP-N-acetylglucosamine 4-epimerase of Pseudomonas aeruginosa, WbpP, an extended SDR, that catalyzes the NAD+ dependent conversion of UDP-GlcNAc and UDPGalNA to UDP-Glc and UDP-Gal. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.72272e-86
NC_017030.1\|WP_014394525.1\|2007989_2009183_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|153418	cd07377, WHTH_GntR, Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators. This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.	5.82853e-14
NC_017030.1\|WP_014394528.1\|2012442_2014125_+\|DUF5060-domain-containing-protein	gnl\|CDD\|379863	pfam16586, DUF5060, Domain of unknown function (DUF5060). This is the N-terminal domain of a putative glycoside hydrolase, DUF4038. It is found in a number of different bacterial orders.	4.41666e-15
NC_017030.1\|WP_014394524.1\|2007079_2007967_+\|beta-xylosidase	gnl\|CDD\|226190	COG3664, XynB, Beta-xylosidase [Carbohydrate transport and metabolism].	5.89975e-52
NC_017030.1\|WP_148282502.1\|2014583_2015534_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176230	cd08269, Zn_ADH9, Alcohol dehydrogenases of the MDR family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.	1.20979e-136
NC_017030.1\|WP_014394530.1\|2015530_2016529_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.98995e-57
NC_017030.1\|WP_014394513.1\|1997734_1998676_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.06806e-92
NC_017030.1\|WP_014394519.1\|2002294_2002783_-\|SRPBCC-family-protein	gnl\|CDD\|176868	cd07826, SRPBCC_CalC_Aha1-like_9, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	1.22035e-56
NC_017030.1\|WP_014394527.1\|2011754_2012312_-\|dual-specificity-protein-phosphatase-family-protein	gnl\|CDD\|350348	cd14498, DSP, dual-specificity phosphatase domain. The dual-specificity phosphatase domain is found in typical and atypical dual-specificity phosphatases (DUSPs), which function as protein-serine/threonine phosphatases (EC 3.1.3.16) and protein-tyrosine-phosphatases (EC 3.1.3.48). Typical DUSPs, also called mitogen-activated protein kinase (MAPK) phosphatases (MKPs), deactivate MAPKs by dephosphorylating the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr motif residing in their activation sites. All MKPs contain an N-terminal Cdc25/rhodanese-like domain, which is responsible for MAPK-binding, and a C-terminal catalytic dual specificity phosphatase domain. Atypical DUSPs contain the catalytic dual specificity phosphatase domain but lack the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. Also included in this family are dual specificity phosphatase-like domains of catalytically inactive members such as serine/threonine/tyrosine-interacting protein (STYX) and serine/threonine/tyrosine interacting like 1 (STYXL1), as well as active phosphatases with substrates that are not phosphoproteins such as PTP localized to the mitochondrion 1 (PTPMT1), which is a lipid phosphatase, and laforin, which is a glycogen phosphatase.	1.82829e-18
NC_017030.1\|WP_014394516.1\|2000221_2000611_-\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	1.7107e-20
NC_017030.1\|WP_193352532.1\|1998672_1999491_-\|acyltransferase-family-protein	gnl\|CDD\|153249	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.	9.76116e-36
NC_017030.1\|WP_043321140.1\|2016574_2018374_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.67127e-163
NC_017030.1\|WP_014394517.1\|2001027_2001810_+\|hypothetical-protein	gnl\|CDD\|163708	cd08152, y4iL_like, Catalase-like heme-binding proteins similar to the uncharacterized y4iL. Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes involved in the protection of cells from the toxic effects of peroxides. It catalyses the conversion of hydrogen peroxide to water and molecular oxygen. Several other related protein families share the catalase fold and bind to heme, but do not necessarily have catalase activity. This family contains uncharacterized proteins similar to Rhizobium sp. NGR234 y4iL, of mostly bacterial origin.	1.06967e-90
NC_017030.1\|WP_014394512.1\|1996515_1997745_-\|tetracycline-resistance-MFS-efflux-pump	gnl\|CDD\|340888	cd17330, MFS_SLC46_TetA_like, Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.31826e-73
NC_017030.1\|WP_014394523.1\|2006499_2006886_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	6.35108e-28

>NC_017030.1|WP_014394521.1|2003377_2004253_-|hypothetical-protein
MTSRLSPWLTLFVMLLALPVLAADAQRTGTWGAYVKEQQLQLSLHPKDKPDSHHGFSAPLTDFQGLSTAEGSSAPFKLVREAGTFDFEGRFKDGQGVGTWRFSPDASFTKKLAELGIPKPDADEQLLLASVNVGPQRVQALAATGQKVTTVDELVQVGIFHVTPEYVRAMAAEGYPKLTLEQLVASRIHNVTPERIQGFAALGFKGLPLDSLLAMSIHGVTPDFIREMRGLGFKDLSADDLVSMRIHGVTPAFVKEMRDAGYENATAEDFVSLRIHGIDSVFVRSMSKKRK
>NC_017030.1|WP_014394520.1|2002900_2003254_-|hypothetical-protein
MRSMIRAWFLMSLSLGVLTACGPSTGADEAAMPGGEAQVEQEIGTDPNCPISQMQSMITWQAQCRTPCSNTAGYDEPNTTNSGYGLPGTKYKRCCPPGGSCTVWKLIGPVCQTCELN
>NC_017030.1|WP_014394519.1|2002294_2002783_-|SRPBCC-family-protein
MTTQVTSSPKALVTQTAEREIRIERIFNASRERVWKALTDPALVARWWGRGNKLVIERMDVRRGGHWRFVEHAEDGTYGFEGRYREVKPLELIEQTFEWDGEPGHVSVDTTTLEDLGDGRTKLVSVSLFHTVEDLKGMIQAGMEQGINQSYAALDTLLVLPH
>NC_017030.1|WP_014394518.1|2001831_2002248_+|hypothetical-protein
MQPFRSLSVGRWALTLAAALMLALPGHAGPPAAPKPTQGDGTVMLTIFFRHDQTKTLEEINAQLDRTGFRKSFPPEGVEVVSWYVMMGVGQVVTLRFPPEKLRTVNLAIEKGAWGAFRTEMYATYDYRPVWQELRNAK
>NC_017030.1|WP_014394517.1|2001027_2001810_+|hypothetical-protein
MALKVLGVDGLGPMLPGHAGQTTQDFVLDTGKVFNASNVKSFLAQITPVENIAPRTPQAVKGMVSAVSLAASKGLHAVGADSSVLDFFGHPLLHPLGESYYSQVPFRYGDSLANLSVTPDSPALRALKDARLDVKDCDGLRKEVVEFFRSNPARFVVGIQLCTDLERMPVEDANAEWSEEESPYQPVARLVFPAQDAYDPAMQDAVDEAMVFCPAHSLAAHRPLGGIMRAHMAVYAAVGRARREQNGQPVKEPRSAGDLP
>NC_017030.1|WP_014394516.1|2000221_2000611_-|VOC-family-protein
MHHSRLSTFVIDCKVEDFDAATRFWSAALGRAVKPVDPDSPNYRELEAKDTEPMLLLQKVEHESRIHLDIESDDLDAELERLEALGAKRVAYVQRWWVMEAPTGQRFCIVRPQRGPLEGRANVWDGEGR
>NC_017030.1|WP_014394515.1|1999593_2000211_+|hypothetical-protein
MAGQPWTGMLDGVLAWARALPAGLSNQVAVDVAGRRVRLSHARVEALSSGVLGRVKGLTLRSWDSTPAVYDLRLDVRGWKLRVETTPQRVELAGGRYTLWLATPGRVELEESPGASSLLMGALRTGAGKAALQALARKLLPPGLAWDGQLLRVEGALPKEGALAARLFESSSLRMTAEHAPEGLWLSAEEWPGLLDLLQAALGPG
>NC_017030.1|WP_193352532.1|1998672_1999491_-|acyltransferase-family-protein
MPQSESLSERVERLELPFNEYGVDPYGISKKHLKLALEFFAFLYRNYFRVRCTGVHHIPKKGRGMLVGNHSGGVAVDGMMVLTSTMLEMDPPRLAQGMVERFIHKFPVASLWASRTGQFTGLPEHAVRLLEDDRLLMIFPEGARGTAKLYPDRYSLVDFGTGFIRLALQTRSPIIPFAFLGGGAAIPTVTNAYALGKLLGVPYVPLTPYLLPLPLPVGLEIHYGEPLVFEGTGDEEDHVIQGYVDQVKASIQRLIEDNRAERNLRRARRLLP
>NC_017030.1|WP_014394513.1|1997734_1998676_-|NAD-dependent-epimerase/dehydratase-family-protein
MKVLIAGISGGIARRLALKLRDSGHEVAGMDVRPWRDAPKGIEVHPVDIRKRAAEDVFRRWKPEAVIHMATVTAFTVQGHERGRINLDGTKALFDHCAAHGVKQVLFVGRHTFYGAAPDSPLYHSEDEPPRALEAIPELADLVAADLYAATALWRLPDVTTAVLRLVYTLGTPGTGTLANLLRGKRVPMVLGYDPLFHVLQEEDVVTALQLALEKQVRGIFNVAGPAPIPLSVIIKGTGRTPVPLPSPVLSLLLGRAGFPRLSVGATDHLRYPIVVDNKRFLEATGFQAAYDEGRILRAYADALPVDRAGHGG
>NC_017030.1|WP_014394512.1|1996515_1997745_-|tetracycline-resistance-MFS-efflux-pump
MVAESVGAAPVATPGLLRRVEAVVFFTVFLDLVGFGIVIPMLPFYVQSMGGSARTVGILLGCFSFTQLLATPLLGRYSDRHGRRSVILLSLLANAVAMVLFALASHQRMLPLLFASRILAGATSGNIAACQAALADVTTKETRARAMGRIGAGIGLGMVLGPTLGGLFSGLGPWVPPLLAGGLALVGFVAAFFAMPETHPVEKRVEAKSQTRWSALQDSPRRKALGMVLGLFFAVFLSMTTLQVAFALLVQARLGWGSKEVGYTFAVVGGLGMVIQGGLIGPLSRAAGEFRLMICGALLLAGGMAGLAVSWQAIPMMVSVVLVGVGTGFLQPLISSQASQVAPPSQQGAVLGLAQSCGGLARTVGPVASGWMYASWSTQAPFLTGMVSALAAAGLGLLLHRETGDDAGR
>NC_017030.1|WP_014394523.1|2006499_2006886_-|BlaI/MecI/CopY-family-transcriptional-regulator
MSRGKLPRPTDAELAILRVLWDGGARTVREVHETLQDGSGYTTVLKTMQIMTEKGLVTRDESQRAHVYSARLPRESTQQQLVTDLVDRVFGGSPARLALQALSTKKTSPEELAELRQLLDSLEKESES
>NC_017030.1|WP_014394524.1|2007079_2007967_+|beta-xylosidase
MIEAVKLWNEPNNKSHWDLELDKDWLIYSRMVRLAGAAVRAEHPTLPRVLGGMSPIDPGFLERLDRQGALDEVDVVAVHGFPLDWNHWPIDEWPLRIAEVRAVSRHPVWVTEVGVSSFGAEEVQEFGLRRTAELLLGRVERLHWYSLYDLPRAWPATTRHREAEGSSYYRHFHMGLLREDGTPKRALRHFADYTPQLGICQWFHFQDPRLDEAVAWLKKLGVRHLRTGLSWADSLRPGAEEWFDQQMRALEDFDVTLTYCFTPESCGMTAHHTSPPNHVEEYADFCARMTRRYAS
>NC_017030.1|WP_014394525.1|2007989_2009183_-|FadR-family-transcriptional-regulator
MGMGRGGLVAYVEAQIERDIALGRLHPSGQFGSEAKLARRYEVCRGTIREALRRLAARGLVVQRPGRKTRAVALDESLTLENLGLALHDERSPEARWLLEGYFSLRRQVLVELLVDCCARASDLDLDRLGSTCFALWNAARWEPGATCAQLEFELLRQAARVADRPGHVLLVQSLQRAFLGGAAQLVPHMGGEALREWATCTMGALSERNVQALQQELPALLKACDELVLNAFAPAPQAHCSPEEDLAQEKQGPLVAPASANAQDEAHEARDLGVPLAATVKDEALEACPGVEADGLRHLAPVSPPGLASGGHGAECAGKDAMGSALGNLSDGRTGWNASSPGRCIQPEPPRTSLHEPSHGVKPSEGSLLQRTRALLGRWASRLWRSIAQAAGPPAS
>NC_017030.1|WP_014394526.1|2009915_2011748_-|hypothetical-protein
MLVHGDHPRVLDPREVLGPLKSRLRRLDTLPPGLERHAELVTLFIEASVLAQGLLDADMEATGEDGAGPQREVRLALPLALAKRLRESWDGVTAPGTASRHALRESSGWSTLSARLQSLERSALPARVTLKEPEGYAHFALYPELYLEAARASRLAGSTRVVGVRSIGTGLACVVAAGLGASSPPVTVRPVGPPFERQLRPGLQLTRELDTAAHSDAVSIVDEGPGLSGSTFGAVADFLEARGMRRERLHFFPSHAGAPGPMASEHHRARWAHAHRHPPDFDTCATRLMAWVEDLTGPAIAPLEDISAGAWRQHLFPDPRDWPAVHVQQERRKYLLTTERGTFLLRFAGLGVPANHRVHRARQLASAGFTPPVTGLRHGFLVQPWLARSHADDLDPAAPRACPLPLARALDRAMLLEHVGRYLGFRARAFPAPEPGRGASLHQLLEMARYNTARVLDEGLARVLDGWMPHLDALAQTTRPVETDHKLHAWEWLVLPGGRLLKTDAVDHHAGLDLVGCQDVAWDIVGAAVELDLSEPALATHVEHASGHRVSPWLLRFYRPCYLAFQCGHHTLAGTTLERTNPDEAARLRSAAARYASRLREHLSSSPAAR
>NC_017030.1|WP_014394527.1|2011754_2012312_-|dual-specificity-protein-phosphatase-family-protein
MRVKERELNLDWVTPLLAVGGSYPMDAAAHLAQKLGVRHVVDVRVECQDDEHVLREHGITFLHLPTVDMRAIHLRMIHDGVAWVRERLTKEQKVLIHCEHGIGRSALLALCVLVDQGLAPLEALELAKTRRPCVSPSPEQLKAFIAYTRDVRAERSVMWTEPTLEALGTIAYRHLRACMETTGGS
>NC_017030.1|WP_014394528.1|2012442_2014125_+|DUF5060-domain-containing-protein
MTPFTKGWPVALWVVLLVGCAAHRPPPAAPAPLQEVERFARFEVGFTVPGITSAPDDVPVHARFVAPSGREMDVGGFPVAGGGFRVRFTPQEVGEYHYRVQAGAKEVASGRFLSRPSSRRGFVRRSTVSAHHLAWDDGTPFLPLGENRFNVYDPTWNQGQQSATEYIAGMAARGMNTLRVFIFTDCEREEPEPGPQPGCLEPRPGVFDPEVAAHYDAILDTAERHGLQVILTLFAVGFTPGETWKSWEDNPYSTARGGPAAMPDDFFDRPQLAERRLRYVLARFGASPALLAVDLLNEPEWDGNVGEATWMPWAVKLAQTWHAEDPYGHLVTVGSVGLHWNVDGDERPWYASRQDDLLQWHLYGKEFYEVHALAAELTRKVAETWGYDKPILLGEFGYGGDDRRTYDHTHVGIWVTTFCGAGVLAHSAPPFTEDSDVPMTPERGRHFRVLADYLARLPPGTPLLPQEAPPASPAGTRAWSMGRPGLHALWVMGAKQGYGEPVSDARVRVRLAPGEYRITWWNDVTGEVLSREQRLVSDPEVSLTVPPFVRHAAGVVEVVR
>NC_017030.1|WP_148282502.1|2014583_2015534_+|zinc-binding-dehydrogenase
MRAAVVGGPRGIRVERVARPEPGPGQVRVRLEGCGVCGSNLPVWEGRDWFRYPLPPGAPGHEGWGVVDALGPDVSGLKPGDRVAMLSSAAFAEYDVADTASTVVLPPSLAGKPFPGEPLGCAMNIFRRADIQPGQTVAIIGIGFLGAVVTRLAAHAGARVLAIARRPWALELARGQGAAECIPMDDHHRIIERVKSLTGNTFCDRVIEVVGEQWPLDLASELTRVRGRLVIAGYHQDGPRQVNLQLWNWRGLDVVNAHERDPQVYVEGMRMAVDAVASGRLDPFPLFTSFPMGELDRAFEAMRARPDGFLKGIVTP
>NC_017030.1|WP_014394530.1|2015530_2016529_+|Gfo/Idh/MocA-family-oxidoreductase
MSATPAAKPRVGFLGVGWIGRNRMEAVVRSEQVQVVGLCDPSADAAREAQALAPGARCVGSLDALLDLELDGLVIATPSAVHAEQSLRALERGVSVFCQKPLGRTAAEVRRVVEAARAKDRLLGVDLSYRFTTGMRQLRERIQEGSLGHVYAVNLVFHNAYGPDKPWFYDPKQAGGGCVMDLGIHLVDLALWTLGFPAVEAVSTRRFAQGRPLASREEGVEDFAAAQLLLGTGTAVQLACSWKLPAGCDAVIEAAFYGTKGGAAFRNVDGSFYDFTADVFQGTKRERLSAPPDAWGGRAAVAWATRLAQGERFDAEAERLVDVATTLDRLYA
>NC_017030.1|WP_043321140.1|2016574_2018374_+|ABC-transporter-ATP-binding-protein
MPNASVPSASLSRAMAWLQPHRRAVVFILLLVLTGSALSALEPLVLKYIFDQLGAQGAARAVLLGVVGLVLMGLTRESLASTANWLTWRTRIGVHYSLNEATVTRLHSLPLSFHREEGVGAIMTRLDRGMQGFVGAITELAFNVVPAAAYLLLSVIIMLRLDWRLALVALAFAPIPVLIARKAAPVQTKREQTLMDRWASIYARFNEVLSGIVTVKSCAMEEREKQRFLHGVREANAVVVRGVGYDAVVSGSQNIVVLVARVASIGMGALLVLKGEITTGTLVAFLGYIGGLFGPVQGLSGVYRTLRTASVAMHQVFSILDAQDHLGDAPDAREVTGVKGEVEFSNIHFAYPSSAGEGRPLLRGVDLKVRPGETIALVGPSGAGKTTLMSLLYRFYDPIQGTVRIDGQDVRTLKQMSLRRHIGVVLQDSLLFNESVRANIAYGRPEASQEEIEAAARAAHADVFIQHLPQGYDTVVGEKGSRLSAGERQRIAIARSLLKDPPILVLDEPTSALDAESEALVQEALGRLMKGRTTFAIAHRLSTVVDADRILVLQEGRIVEQGRHEELMHHGGYYASLVRRQTRGLLPDRPLAPPSPLSA
>NC_017030.1|WP_014394532.1|2018494_2019616_+|NAD-dependent-epimerase/dehydratase-family-protein
MGRKHILITGGAGFIGSHLADELLAHGHRVRALDALVPQVHGPGYERPDYLSPEVELHVGDVRDAQAVRRALEGVDCVVHLASAVGVGQSMYEVAHYTSVNNQGTAVLLQALIERPVERLVVASSMSVYGEGLYLTPDGRTAPGPERSLSQLQAGDWEPRDANGARLTPVPTPEDKTPTLSSVYALSKFDQERLCLLVGRAYRIPTVALRFFNVYGPRQALSNPYTGVLAIFASRLLNGNAPLLFEDGLQQRDFVNVHDVAQACRLALQVEGAAGQVLNVGSGRAVTVREVARAVGEVMGLSRMRPAVTGKYRMGDIRHCFADITRAREVLGYAPRVGFQEGLLELSRWLVGQAAQDRAAQARAELDARGLTV

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Crispr_ID: NC_017030_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_8

2120436-2121350

Orphan

Consensus_repeat	Method
AAACCTGTCGGACAGTCGGACA	CRT
ACCTGTCGGACAGTCGGACAAGTTGGG	PILER-CR

13 spacers

The CRISPR arrays of NC_017030_8

>merge|NC_017030|8|2120436-2121350|CRT,PILER-CR
AAACCTGTCGGACAGTCGGACAGGTTGTGCGGACCGTGCCCGGGTCCTCTCGCGGACTCCTGGACGAGGAAACCTGTCGGACAGTCGGACAAGTTGGAAGGACCGTGGCAGGCCCCCCAGGCTGCCCGGGCAGCAGGAAAACCTGTCGGACAGTCGGACAGGTTGGGCGGCCCTCAGCCGGAAGCTCCTGTTCCATCCCGACGGCGAAAACCTGTCGGACAGTCGGACAGGTTGGGGGCCTTGGTCCGGCTCCCAGGGGCCGGATCCAGGAAGCAAAACCTGTCGGACAGCCGGACATGCTGGGGGATCCTGGCGGGGCTCCCAGGCGCCGACTCCAGGCCGCGGGAACCTGTCGGACAGTCGGACAAGTTGGGCGGACCGTGGCAGGTCCCCGCGCTGCCCCGGGCAGTTGGAAGACTTGTCGGACAGTCGGACAAGTTGGGCGGACCGTTACCGGGCCCTCGGCGCTGGTTCCTGGCCGCGGGAACCTGTCGGACAGTCGGACCGGTTTGGGGGACCAGGCAAGCCCTGGGGCGACCCCGAATGGCGGAAACCTGTCGGACAATCGGACAGGTTGGGCGGACCGTGACCGGGCCTTCGGTGCTGGCTCCAGCCTGCGGAAACTTGTCCGACAGTCGGACCTGTCTTGCGGACCGTGGCTGGTGGGGGCTCCTCCCCGTCCGGGCAGTGGAAACCTGTCGGACAGTCGGACAGGTTTTGGAACACCGCCGCCGGGGGAGGTCTCTCCCAGCTCGGGCCGAGGAAACCTGTCGGACAGTCGGACAGGTTGGGGACCTTGGCGGGGCTCGTGGGCTTTGGCTCCGGACCGGGGAAACTTGTCGGACAGGTTGGGGACCTTGGTCGGGCTCGTGGGCTTTGGCCGCGGACCTTGGAAACTTGTCCGACAGTCGGACA

>NC_017030|8|2|2120436-2121350|CRT
AAACCTGTCGGACAGTCGGACA	GGTTGTGCGGACCGTGCCCGGGTCCTCTCGCGGACTCCTGGACGAGG
AAACCTGTCGGACAGTCGGACA	AGTTGGAAGGACCGTGGCAGGCCCCCCAGGCTGCCCGGGCAGCAGGA
AAACCTGTCGGACAGTCGGACA	GGTTGGGCGGCCCTCAGCCGGAAGCTCCTGTTCCATCCCGACGGCGA
AAACCTGTCGGACAGTCGGACA	GGTTGGGGGCCTTGGTCCGGCTCCCAGGGGCCGGATCCAGGAAGCA
AAACCTGTCGGACAGCCGGACA	TGCTGGGGGATCCTGGCGGGGCTCCCAGGCGCCGACTCCAGGCCGCGG
GAACCTGTCGGACAGTCGGACA	AGTTGGGCGGACCGTGGCAGGTCCCCGCGCTGCCCCGGGCAGTTGGA
AGACTTGTCGGACAGTCGGACA	AGTTGGGCGGACCGTTACCGGGCCCTCGGCGCTGGTTCCTGGCCGCGG
GAACCTGTCGGACAGTCGGACC	GGTTTGGGGGACCAGGCAAGCCCTGGGGCGACCCCGAATGGCGG
AAACCTGTCGGACAATCGGACA	GGTTGGGCGGACCGTGACCGGGCCTTCGGTGCTGGCTCCAGCCTGCGG
AAACTTGTCCGACAGTCGGACC	TGTCTTGCGGACCGTGGCTGGTGGGGGCTCCTCCCCGTCCGGGCAGTGG
AAACCTGTCGGACAGTCGGACA	GGTTTTGGAACACCGCCGCCGGGGGAGGTCTCTCCCAGCTCGGGCCGAGG
AAACCTGTCGGACAGTCGGACA	GGTTGGGGACCTTGGCGGGGCTCGTGGGCTTTGGCTCCGGACCGGGG
AAACTTGTCGGACAGGTTGGGG	ACCTTGGTCGGGCTCGTGGGCTTTGGCCGCGGACCTTGG
AAACTTGTCCGACAGTCGGACA

>NC_017030|8|2|2120438-2120878|PILER-CR
ACCTGTCGGACAGTCGGACAGGTTGTG	CGGACCGTGCCCGGGTCCTCTCGCGGACTCCTGGACGAGGAA
ACCTGTCGGACAGTCGGACAAGTTGGA	AGGACCGTGGCAGGCCCCCCAGGCTGCCCGGGCAGCAGGAAA
ACCTGTCGGACAGTCGGACAGGTTGGG	CGGCCCTCAGCCGGAAGCTCCTGTTCCATCCCGACGGCGAAA
ACCTGTCGGACAGTCGGACAGGTTGGG	GGCCTTGGTCCGGCTCCCAGGGGCCGGATCCAGGAAGCAAA
ACCTGTCGGACAGCCGGACATGCTGGG	GGATCCTGGCGGGGCTCCCAGGCGCCGACTCCAGGCCGCGGGA
ACCTGTCGGACAGTCGGACAAGTTGGG	CGGACCGTGGCAGGTCCCCGCGCTGCCCCGGGCAGTTGGAAG
ACTTGTCGGACAGTCGGACAAGTTGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014394626.1\|2134139_2134571_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394608.1\|2108030_2108942_+\|phospholipase	unknown	unknown	gnl\|CDD\|226584
NC_017030.1\|WP_148282205.1\|2122578_2123937_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394615.1\|2118524_2118992_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NC_017030.1\|WP_148282506.1\|2130002_2131946_+\|2,3-oxidosqualene-cyclase	unknown	unknown	gnl\|CDD\|274591
NC_017030.1\|WP_014394612.1\|2115079_2115922_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_017030.1\|WP_014394624.1\|2131893_2132400_-\|DUF1993-domain-containing-protein	unknown	unknown	gnl\|CDD\|370447
NC_017030.1\|WP_014394613.1\|2115950_2116340_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319923
NC_017030.1\|WP_014394625.1\|2132501_2133926_-\|RtcB-family-protein	unknown	unknown	gnl\|CDD\|376465
NC_017030.1\|WP_014394619.1\|2124042_2126316_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_017030.1\|WP_014394620.1\|2126312_2127503_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|132512
NC_017030.1\|WP_014394609.1\|2108942_2110697_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|224594
NC_017030.1\|WP_043321153.1\|2116345_2118460_-\|M3-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341051
NC_017030.1\|WP_014394611.1\|2114189_2114927_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|226674
NC_017030.1\|WP_014394617.1\|2121468_2122428_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132002
NC_017030.1\|WP_014394621.1\|2127442_2128852_-\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|223727
NC_017030.1\|WP_014394616.1\|2119081_2120386_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NC_017030.1\|WP_014394610.1\|2110779_2113875_-\|DUF3427-domain-containing-protein	unknown	unknown	gnl\|CDD\|197297
NC_017030.1\|WP_014394622.1\|2128938_2129985_+\|squalene/phytoene-synthase-family-protein	unknown	unknown	gnl\|CDD\|173831
NC_017030.1\|WP_014394607.1\|2106954_2107824_+\|transcriptional-regulator-GcvA	unknown	unknown	gnl\|CDD\|182990

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014394608.1\|2108030_2108942_+\|phospholipase	gnl\|CDD\|226584	COG4099, COG4099, Predicted peptidase [General function prediction only].	7.05584e-16
NC_017030.1\|WP_014394615.1\|2118524_2118992_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	4.09762e-35
NC_017030.1\|WP_148282506.1\|2130002_2131946_+\|2,3-oxidosqualene-cyclase	gnl\|CDD\|274591	TIGR03463, osq_cycl, 2,3-oxidosqualene cyclase. This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.	0
NC_017030.1\|WP_014394612.1\|2115079_2115922_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	5.95408e-25
NC_017030.1\|WP_014394624.1\|2131893_2132400_-\|DUF1993-domain-containing-protein	gnl\|CDD\|370447	pfam09351, DUF1993, Domain of unknown function (DUF1993). This family of proteins are functionally uncharacterized.	2.71187e-72
NC_017030.1\|WP_014394613.1\|2115950_2116340_-\|VOC-family-protein	gnl\|CDD\|319923	cd07262, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.48057e-38
NC_017030.1\|WP_014394625.1\|2132501_2133926_-\|RtcB-family-protein	gnl\|CDD\|376465	pfam01139, RtcB, tRNA-splicing ligase RtcB. This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyze the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage.	2.90076e-118
NC_017030.1\|WP_014394619.1\|2124042_2126316_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.46131e-93
NC_017030.1\|WP_014394620.1\|2126312_2127503_+\|glycosyltransferase	gnl\|CDD\|132512	TIGR03472, HpnI, hopanoid biosynthesis associated glycosyl transferase protein HpnI. This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The member of this clade from Acidithiobacillus ferrooxidans ATCC 23270 (AFE_0974) is found in the same locus as squalene-hopene cyclase (SHC, TIGR01507) and other genes associated with the biosynthesis of hopanoid natural products. Similarly, in Ralstonia eutropha JMP134 (Reut_B4902) this gene is adjacent to HpnAB, IspH and HpnH (TIGR03470), although SHC itself is elsewhere in the genome. Notably, this gene (here named HpnI) and three others form a conserved set (HpnIJKL) which occur in a subset of all genomes containing the SHC enzyme. This relationship was discerned using the method of partial phylogenetic profiling. This group includes Zymomonas mobilis, the organism where the initial hopanoid biosynthesis locus was described consisting of the genes HpnA-E and SHC (HpnF). Continuing past SHC are found a phosphorylase enzyme (ZMO0873, i.e. HpnG, TIGR03468) and another radical SAM enzyme (ZMO0874), HpnH. Although discontinuous in Z. mobilis, we continue the gene symbol sequence with HpnIJKL. Hopanoids are known to feature polar glycosyl head groups in many organisms.	2.07049e-25
NC_017030.1\|WP_014394609.1\|2108942_2110697_-\|serine-hydrolase	gnl\|CDD\|224594	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms].	1.46041e-32
NC_017030.1\|WP_043321153.1\|2116345_2118460_-\|M3-family-metallopeptidase	gnl\|CDD\|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0
NC_017030.1\|WP_014394611.1\|2114189_2114927_-\|SDR-family-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	1.30291e-87
NC_017030.1\|WP_014394617.1\|2121468_2122428_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	2.7337e-64
NC_017030.1\|WP_014394621.1\|2127442_2128852_-\|FAD-dependent-monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	3.94002e-43
NC_017030.1\|WP_014394616.1\|2119081_2120386_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	4.46685e-33
NC_017030.1\|WP_014394610.1\|2110779_2113875_-\|DUF3427-domain-containing-protein	gnl\|CDD\|197297	cd09203, PLDc_N_DEXD_b1, N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain. N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain. All members of this subfamily are uncharacterized. Other characterized members of the superfamily that have a related domain architecture ( containing a DEAD/DEAH box helicase domain), include the DNA/RNA helicase superfamily II (SF2) and Res-subunit of type III restriction endonucleases. In addition to the helicase-like region, members of this subfamily also contain one copy of the conserved HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue) in the N-terminal putative catalytic domain. The HKD motif characterizes the phospholipase D (PLD, EC 3.1.4.4) superfamily.	1.38212e-68
NC_017030.1\|WP_014394622.1\|2128938_2129985_+\|squalene/phytoene-synthase-family-protein	gnl\|CDD\|173831	cd00683, Trans_IPPS_HH, Trans-Isoprenyl Diphosphate Synthases, head-to-head. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze a head-to-head (HH) (1'-1) condensation reaction. This CD includes squalene and phytoene synthases which catalyze the 1'-1 condensation of two 15-carbon (farnesyl) and 20-carbon (geranylgeranyl) isoprenyl diphosphates, respectively. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DXXXD) located on opposite walls. These residues mediate binding of prenyl phosphates. A two-step reaction has been proposed for squalene synthase (farnesyl-diphosphate farnesyltransferase) in which, two molecules of FPP react to form a stable cyclopropylcarbinyl diphosphate intermediate, and then the intermediate undergoes heterolysis, isomerization, and reduction with NADPH to form squalene, a precursor of cholestrol. The carotenoid biosynthesis enzyme, phytoene synthase (CrtB), catalyzes the condensation reaction of two molecules of geranylgeranyl diphosphate to produce phytoene, a precursor of beta-carotene. These enzymes produce the triterpene and tetraterpene precursors for many diverse sterol and carotenoid end products and are widely distributed among eukareya, bacteria, and archaea.	6.29917e-47
NC_017030.1\|WP_014394607.1\|2106954_2107824_+\|transcriptional-regulator-GcvA	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	2.86892e-115

>NC_017030.1|WP_014394616.1|2119081_2120386_+|FAD-dependent-oxidoreductase
MQATKVAVVGGGLGGLTAAALLARGGCEVTVYERSKHLGGRARTTEVEGFRFNLGPHALYRAGAAFRVLERLGVKPTGGIPNQTGSHALVGGRLHTLPRGAVTLMTTDVLSLASKLEVAKLLAGLARIDTQPLGAMSMREWLETHLTRKDSQALIGALIRVSSYCADFEALSAEAGLKQLQCATAANVLYVDGGWSTLVDAVERLGREAGARLELSARVDAVVLQEGGKWVEGVRLADGTVHRADAVVMAGSPADVAALMPGDAVLAREAREAVPIQAATLELGLSALPRPDALFALGLDGPWYASVHSASAKLAPEGGAMVHVAKYLGGADTEASEAALEAVMDALQPGWRAKVVARRYRPSLTVSAGLPRAVNGGLTGRPSVEVPHVGGLFRVGDWVGSEGMLADASLASAEAVEQALVRRTATSQRRAAGT
>NC_017030.1|WP_014394615.1|2118524_2118992_+|Lrp/AsnC-family-transcriptional-regulator
MAALDRIDRVILEALQNNARLSNKELAAKVGLAPSSCLARVKRLETDGVIRSYRAELDPRPLGLGLQALIGVQLRLHVGEHFGSIGDHLRSLPETVAVYCLGGTTDFLVHVVCRDTEHLRVLTIQSFTSRPEVSRIETSLVFSFARSGLPVDRGA
>NC_017030.1|WP_043321153.1|2116345_2118460_-|M3-family-metallopeptidase
MPRHRIAACLVLLAGTAFAAPASSPDVLLAPWSGPHGGVPPFDRARVEDFAPALEAAMAQARNEVAAIADSKEPPTFENTVAAYQDSGRAFNRVYEVYNAWSSFVSSPEYQAVERELAPRLSAFWDEEPQNRKLFRRIKAVRDSAAKAKLTPEQQRLVAYYYDDFVRSGALLDAAGAKRMAALNQRLATLYTTFNQNVLADEKRYTLLENEADLAGLPEPLRKAVAAEATARGQPGKWAVANTRSVVADFLTYSERRELREKVWRNYDSRGDHGDAHDNNAIITQILAARAEQAKLMGFPTHAHRQLQRAMVKTPERAMKLLETMWTPAVARVREEVTAMTAIARSQGQQEPIAPWDYRYYAEKVRKQAYDFDDSEVKPYLQLETLREGMFWVAGQLLGYTFTPAPDVPVYHPDVRVFAVKDRESGRERGLLYFDPYAREGKYNGGQTETYRVQERFRGEVPALVAISMPFVKPGAGSPALLGWRDAQTLFHEFGHALHTLSGDVTYPSLGGGRVVSDYAEFPSKLFEHWLATPEVLSRFAVHHTTGQPMPQALVARIQKAATFNQGFYTVDFLTSALVEMKMHLAGAKRIDPDAFERDMLRQMGAPAEVGMRFRMPHFGHVFASNAYAAGYYRYLWADMLASDAFEAFQEAGGAYDAKVAARLREHVLSVGNTIDPFEGYRKFRGKDASLDALMRERGFAPIH
>NC_017030.1|WP_014394613.1|2115950_2116340_-|VOC-family-protein
MIDHTGIGVSDVARSAAFYDAALGALGLRRAIQLPTDTGADGIGYGRDFPIFWIDRFHPHGVKQHTAFAATSRAQVDAFHAAAVAAGGTDNGPPGLRGVETGYPAGYYAAFVLDPDGNNIEAVFREPSR
>NC_017030.1|WP_014394612.1|2115079_2115922_+|helix-turn-helix-transcriptional-regulator
MPALHHAVVDGPLSIQTFLFPELPGLRLVRYRTDGRLLRSVKERFSVMVTQRGHSEWWGRGRVHSSSPRTVDLKQMGEVHRDLRRDGPARFQVIAFDESLVAEAREALGAPASARLRQLQLETSQPSAADFVRLHAVLDAGLAGRSSALALQTALTEALSSLVGCLEHPGSVEQRYRWPIRRVVEALHEAIPEGITLESLARQVGWNRFHLCRAFREELGMPPHAYLTHLRVSRAQRLLSQGLAPAEVALQVGLCDQSQLNRHFKRIVGITPGQFARAVQ
>NC_017030.1|WP_014394611.1|2114189_2114927_-|SDR-family-oxidoreductase
MSGIQDKVIAITGASSGIGEAAALLLAGRGAKVVLGARRLERLGPVVERITQAGGEALSARTDVRRREDVAGLVHLACERFGRLDVLINNAGSLATSPLDDLRVDDWEELVDTNIKGVLYGIAAALPVFRQQGFGHFINTASTSAHRIVPGQAVYAGTKFAVRAISEGLRQEAGPRLRVTVISPGMTRTNFLEHVKNPELRARFEEVRDKLAISPDAIARAMAYAIEQPADVDVGEVIVRPTAQD
>NC_017030.1|WP_014394610.1|2110779_2113875_-|DUF3427-domain-containing-protein
MSQNERGLYETLITEALEGPLGALDHRLEANRSALHEAEAADRIGLHLARVVERALASLDRKERVAIGTALARKVVELVVDATEASTLLSERPVEPGSMLRSILGKLPDGSTETLSEPLIPLLDTTLLTNAPGEPRIGSQVLAEIHSADHIDVVMAFIRRSGIAPMMGALRAHCQAGRRLRVLTTTYTGSTEARALDALRELGADIRVSYDQTSTRLHAKAWLFHRQSGFSTAYIGSSNLTHSAQVSGLEWNVRASRARNESVVDKVAAVFESYWNSGDFVPYDREQFLARTASADDHGSQIELSPIELRPEPFQERLLEQIALSRKLGHHRNLLVSATGTGKTVMAALDYARLSEELPRARLLFVAHREEILTQTRATFRHALRDHSFGELWVGGDRPSYFEHVFASVQSLNASGLEHLDAAHFDVVIVDEFHHAAAPTYQNLLEHLRPAELLGLTATPERSDGMPVLDWFEGRIAAELRLWDAIDQHRLVPFAYYAIHDGLDLREIPWRRGRGYDVESLSNLFTHNDAWVRLVLKEVARRSEDLSQMRALGFCVSVEHARFMARAFSAAGIRAVAIWSDTPDDERRQALRDLAQRRVNVVFSIDLFNEGVDVPAVDTLLMLRPTDSPTLFLQQLGRGLRRHPSKSVCTVLDFVGHHHSEFRFDHRLRALLGGTRAEVIRQFEKGFPFLPAGCHMEFDRVASEIVLASIRNSVPSRWSEKVDELRRYAKGAAAVSLTGFLAETGLELEDIYSADKNWSDLCQDAGLAVLPAGPYEPSLRRACGRLLHLDDSARIDTYRRLLGSEAVPKAEALSLVDRRMLRMLVASLVDKAVTKTSALEEGCAILWGHPQVRQEVLALLNTLSGRISHLPSRLVSHPDVPLTVHARYTRIEILAAFGVGDGAKVAPWQTGVYWARESKTDLLAFTLDKTSGHFSPTTRYRDYAISRDLIHWESQSVTRAASETGQRYQHHVQQGSSVMLFARQRSDDRAFYFLGPATYMKHEGELPMAVTWRLEHALPGDLFASFAAAVA
>NC_017030.1|WP_014394609.1|2108942_2110697_-|serine-hydrolase
MRPSLLRLSLLLAVLSQGGALAQGADPAKTLVGTWGGERTYGPEVQGELTLFRDPGGWHASIGGFTASGVLDKQTLTFTLPGGKGDFRGSLSADGKRILGHWIQPRILVGGVRYATPVELRLLQKDVWRGSVAPLDDTFTIYFVIQEMPDGAIHAFIRNPEKNLGRQGTFRVSLKDNAVSLVETRPGGMRFNGTYDADAGKLSLNVLFLGTLDLTRRERDQAVGLDPRTPASPVYTYRKPIADGDGWATASLADVGMDEAPIRALVQGILDTTPGPTPTPLIEGLLIARHGKLVVEEYFHGQDSERPHDLRSASKTFAPLLVGAAIDQGAKLRPESPVYPLLPGGTDLAAQDPRKARITVEHLMTMTSGLACDDNDDSSPGNENTVQDQPSGWYTYTLNLPMAREPGEDTAVYCSAGIHLLGAVLHEATGTWLPELFERTVATPLQMRRRHINLSPDGDAYLGGGLYLRPRDALKLGQLYLSGGVWNGRRVISRRWVERSTARHAEMSPGRTYGYAWWRHELKVGDRVYAEYEAGGNGGQYVMVVPELDLAVAFTGANYGQFALWKRVREELLPRYILAAASWK
>NC_017030.1|WP_014394608.1|2108030_2108942_+|phospholipase
MRMPWIALVVVLGAIACGGSFEPGEAETWGTHEAGLTITTEDQVVARLPASTGAGYGYGEYLPPGYLTSTTSYPVIIHLNGAGEFGTSPTEADLLGYVTRHGALKNIHKTAQGKAYFGQHQVMVFTPRAHANWQPAAIDAFISFIVANYRVDTTRIYLTGISFGGYGAWQYAYTYGSRLAALAPMATNIGAPGPTITQLKNVPVWAVHSFADGSSLSAETSWLTGVTKNYGLFQPVQVTAPTQKVTYLFPGASSPVWSSPQPGAVATGSDIARLTVLPGGVHDCWTQQYDNYAFWDWLLAQHR
>NC_017030.1|WP_014394607.1|2106954_2107824_+|transcriptional-regulator-GcvA
MRRIPPLGALRAFEAGARHLSFTRAATELRVTQAAISHQVRQLEDWLGVSLFERRGHALTLTARGAEYLRELTPVFERMSEATARLYAREQGPLRLTVLPSFASCWLLPRLERFRKQHPDIELHVNSSEALWDFLDDRFDVGIRSGLGRWTGLKAEQLASERLSPVCTPALAKRLRAPGDLGKARLLHDSPKDGWRRWLDAAGVSGVDADRGPVFNDAGLALQAARLGDGVALGRLMLAAEDLEAGRLVQPFKAVLPNDFSYWLVHPRPLTGRRDVAAFKAWVLEEARR
>NC_017030.1|WP_014394617.1|2121468_2122428_+|sigma-70-family-RNA-polymerase-sigma-factor
MDSQARGALGQAAREHERFLWGLCYRMTGVAADADDLVQDVYARALATPPERLDTLRPWLTRVAVNLARDHLRRRRREGYVGPWLPSPVETGDEEVLPAVEARLPGGGSTEGRYELLESVSFAFLLALEALSPKQRAVLLLRDVFDYSVLEVAEALRMSEANVKVVHHRARSAMAAYDQSRCVPTRDVQERTRASLEAFLGALVTGDVAAAEALLASDVRALSDGGGKVRAALVPIVGPQRVVLFMRRLLEMRGPPVAWEARMLNGLPAVVAVFHPGADPLLALNTVLRVDVDSSGRIHALHSVLVDRKLMGVRMPVPE
>NC_017030.1|WP_148282205.1|2122578_2123937_+|hypothetical-protein
MLGGLTLLAGCGREPRPVEVIQSRGAEGVALLIEREAGTGPYVESTAERFRVVASGEVIKSVRWSANAGVVEPSDERVTWTLPTAGTASLSVTVETESGKTAEGAFQFSVVAAPLASHSAIDTRPDVTGSSCDIAFDSTGKGHVIYTNDTHNSLWYASWDGASWTTEQIDGPGFNNGGVFVVKSQLVVDPVTGTPHVAYSKGTGNITNTTTRVGYATRVNGAWVREEVDSSVVMRFSIALNPAQAQQPVIVFTSNPSAGVKVATRTAANTWSTVTPSTSIHALTSDALFDATGALHFITHQSASGYVSQYLQVLRGSTLESFALKTSTSAPWLATAWGPDSHLLALSNGISEGEWNAIEDITVGTPAASSTRRVSTVDYKYASSALAYGGGKPVVVLRNGTALTLGTTDAQGFWTYTQLGTVEDNSRPSVAIRPTDGVPHVCYQRDGKVTFQ
>NC_017030.1|WP_014394619.1|2124042_2126316_+|MMPL-family-transporter
MAGRGDDSPVGGGPSLFARLAVGVFRHRGRVLVGTLLLLAAAVWALLRGGHLTTGTIEGIESARAEALARGAAAGSNDQTLAVIFHHDEWTTDEPRFAQAVTSVLSRVERLPEVASVVSPIGAPEAFRARFVARTGHDLLALVRLKGGEREATAAFPAVRAALENPDLRTTLTGKVAFLAALNELLEHDLLRAELLSFPLALVVLLWVFRTVVAAMLPLVVGGLAVLCGVAGVMLLSHATNMAQYTLNVVSLIGLGVAIDYSLFIVSRFRSELALGLSTEHALTRTLDTAGRAVAFSGLAVTVGLGGLLFFRGSYLSAMGLGGALVVAFAVLFALTVLPALLAWLGPRVDRGRLPFARKEGRGGAWHALATWVMRHPWWVLLPTLTLLLAMGLPFRRLQLAATDITALPEGTEARQGAETLARLFPREAATRVLVAVEFPGGSPLTPERAGALYDASRRVASMPGVVGVESAVDLGPGMDRATVLRMAAAPPQFLPPELQAARAAYVTGNVAVMQVLTSSAPSSLEARNLVRALREDRTVGDGRWLVGGQTATDVDAAAFVRHHTPAAVGFVMGMTCIVLFVLLRSVVLPLKALLMNLLSLAGSFGALVWIFQEGHLHRLLRFEPGPIEPSLPILLFCALFGLSMDYEVLLLSRIREEYLRTGDNTHAVAEGLEKTGGLITSAAAIMVAVFAAFTLASVVVVKAMGLGMAIAVALDATLVRVLIVPAMMRLMGDFNWWGPGHWRRSHPREQGTEVRS
>NC_017030.1|WP_014394620.1|2126312_2127503_+|glycosyltransferase
MSARNLAWTAAALGVLVHGHRELMAGLRRRAAPPMKHFEPPSVTVIRPIRGLDVDARENVRALLELDYPGEWEVLFVFDSEDDPAFLPTREEVAARPTRAKRVELIVAGEPPAGMTGKLNAMQVGVACSRCQLLAFSDSDTRPSPGVLTALVGALLEDRETGATFAPIYAAADAPLAGDVGYGLLVNAWYGASVACTAEPDGSLPFIMGQLMVFRRQALEAIGGVGCAVGQFVDDMYLGRRLYLAGWKNRVVHAPLRVVTGQLGLGAFLRIFRRWILFSEAGIPGTFARPHWVRGAVSWLSWGALVTAAARRAWGPALLSAVPIGFSVWSQLRLQRACHGPEVAPRHYWVPAVLPLLGAGVAVSARLSREVDWRGRGYRLDAKARLGEAQPARASV
>NC_017030.1|WP_014394621.1|2127442_2128852_-|FAD-dependent-monooxygenase
MGDTEVVIAGGGPAGCAVAAALSDLGWSVLLLDAGVDRHKQLAGELLHPPGVRDLRALGFGDVVDGWAAHPVRGFAVRFHAPARTLVLPYGRGVTGLSLEHAALTLPLLESVSRRRGVTVCTRARVTAVEHNCERGVRLRYSHEGTEHTVHARLLVAADGRASPVRRMLGIAEHHQRLSTMLGVTVDSACLTHPEHGHQFVGGAVHALAYTIQPGVARVMVDLPLGSTAQTLKEQPELLLALPSRLREAVRQALEQRPAVRMASNDDWLAETVWMGSAVLVGDAAACCHPLTASGMASCFHDARALQESLDRYPGHVARALEHYAHARRPAQRTRVALASALYSAFARQDEGMHALRMGLLHYWEHSPGGARASMALLSSEEPRMRVMAREYLRVVAHAFAAMLSPNGTGGSLRSAAPLLRSAGPPLRGTVASAVEQVGSWLHRRVRRPVYTLARAGWASPRRAFASNR
>NC_017030.1|WP_014394622.1|2128938_2129985_+|squalene/phytoene-synthase-family-protein
MKVQVASFCRTQLPRVSRTFALNIPLLPEPLDLAVTVAYLLCRIADTLEDEAPGALHGALLDELGGLVSLEPGWEARARSFARRARLALRDEAPPAEAELVSETPTVLETLASLPSWVHPPIARCVRTMAGGMNQIQRMHGGSGQVMGLPDLQATFMYCYYVAGVVGEMLTGLFVASSPRVAWREERLMSRAPAFGRALQLTNILKDVREDLDRGSCWLPRDRMAAHGLTPATLALPSLRANAVALLDELVAVARRELDVALEYSLALPVEEPGLRLFCLYPLFFAAATLDVVEGNPAVFEPEPVKIPRETVAMLMQLTQERVGSDEALRALHASVSRGSRDGAEAWS
>NC_017030.1|WP_148282506.1|2130002_2131946_+|2,3-oxidosqualene-cyclase
MLAGTQAADGSWKGDYSGPLFLGPVYVAGLYVMGRTPEASVRDGMVAHMRAHQNADGGWGLDVESPSLVFTSVLNYVAQRLLGVGADDPGLVRARAWFLPRGGPLSSASWGKFLLALLGLYEYEGLAPVPPELWLLPRGLPFHPSRLWCHCRMVYLPMGWLYGRRARAPETPLLAELRRELYPQPYADVDWKAARGRVARTDAYSPHGLGLRAVHRVLGWYERFHSKRLRERALEESLELIRGEDEATHFVCIGPINKVLDMVVWHVARPDGPEVRAHLERLPDYLQHTHEGVAVNGYNSSQLWDTAFAVQALVAAGESAWARDTLERAGRFLEAQQVLEDSPDAARHHRHPSRGGWPFSTRAHGWPISDCTAEALKACLLLEPLGLNRVPRERLEQAVAFILSLQNRDGGWATYEQQRGPRWLERFNPSDVFAGIMVDPSYVECTSACIQALAAWRGAWPHAPVGQSIARGADFLRRQQRPDGSWEGAWGVCFSYGTWFGVTGLVASGAGTGDPALRKAVTFLKAHQREDGAWSETIQACRERRWVEGRTGHAVMTSWSVLSLVAAGEANAEATRRGVAWLRERQEAEGQWPREPLAGVFSRTCAIHYDAYLRIFPLWALSLAERQAGAFRAREGSATPGSPPCPG
>NC_017030.1|WP_014394624.1|2131893_2132400_-|DUF1993-domain-containing-protein
MYFETFSQMKKQLGQLSKWLETAAAHAKAKSFDPNLYLNFRLAPDQLPFVRQVQIGCDAVKLAASRLSGKAAPSNPDTEQTLEELSARVRSTIAYLDTFTAKDFEGAAGRIVTHPRWEGQVMSGADYFLENAVPNFFFHVTHAYALLRHNGVNLGKADYLGSQSLRAP
>NC_017030.1|WP_014394625.1|2132501_2133926_-|RtcB-family-protein
MQPKLNRLLRALAREGLDVAYDGRVYTVRLQADPHAPPAEVLLPPDLPVEGKALQQLAALAALHHPDGGRVKQVRATPDFHPGDSGVAIGSVVHTEGLVVPGAVGTDINCGMRLHVADIPVDAFLARRDAFVERMKGHYFFGTRDVAQGSRALEALLRDGLPGWLLETEDQPLGMAARVDLGQLHRESGRVHLGGALEGDPAWAPTGLRREGVVRDPGLATIGGGNHFVEVQRVEAVVDRARAWAWGVREGQLAFMVHSGSRDMGKHVGRTWQERARAAWPSGAPHPASGIFPLADPAKVREYLKAEATAANYAFLNRLLLAELVRQTLRELFGDVEAPLVYDVPHNITLPWEGGWLARKGACPAEEDQPVIIPGSMGATSYLMRGLGNAKALASASHGAGRAHSRFSMSRGGAKHREEDLGLTGVDCIAMRAERRIEEAPAAYKPIGPVVASQVDADIVREVARLRPLMTFKA
>NC_017030.1|WP_014394626.1|2134139_2134571_+|hypothetical-protein
MTVAVLRAQAPEFDVASVLDRFPECHPDAVWLQGEQHLRQGRHSTSGFNLTLVEDGEGTLHGPVAAARRQLEVLAPLLAELRQQAVPCIVDFGLFVGTARHFTSSIHFPPDDVRWFADQGIALAVSAYPTAEEESEDSSGNLQ

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Crispr_ID: NC_017030_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_9

2188019-2188164

Orphan

Consensus_repeat	Method
CGACGGCCACGAAGCCCACGGCGACGACG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_017030_9

>merge|NC_017030|9|2188019-2188164|CRISPRCasFinder
CCACGGCGTCCAAGCCCAAGCCGCCGGCGCGCGCGTCGACGCTCCCCGCCTCGACGACGGCCACGAAGCCCACGGCGACGACGGCCACGAAGCCCACGGCGACGACGACGCCCGCGGCGACGGCCACGAAGCCCACGGCGACGACG

>NC_017030|9|6|2188019-2188164|CRISPRCasFinder
CCACGGCGTCCAAGCCCAAGCCGCCGGCG	CGCGCGTCGACGCTCCCCGCCTCGA
CGACGGCCACGAAGCCCACGGCGACGACG	GCCACGAAGCCCACGGCGACGACGACGCCCGCGG
CGACGGCCACGAAGCCCACGGCGACGACG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014394663.1\|2178349_2178766_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
NC_017030.1\|WP_014394676.1\|2193471_2194386_-\|NmrA-family-NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|187561
NC_017030.1\|WP_014394670.1\|2184599_2185505_-\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|378155
NC_017030.1\|WP_014394677.1\|2194491_2195043_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_017030.1\|WP_014394674.1\|2190978_2192001_+\|deoxyhypusine-synthase-family-protein	unknown	unknown	gnl\|CDD\|224811
NC_017030.1\|WP_014394671.1\|2185599_2187609_-\|DNRLRE-domain-containing-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394666.1\|2179754_2180192_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394669.1\|2182729_2184577_+\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|320687
NC_017030.1\|WP_014394665.1\|2179248_2179743_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394673.1\|2189271_2190150_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274033
NC_017030.1\|WP_014394679.1\|2198221_2200018_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394668.1\|2181722_2182622_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_017030.1\|WP_014394662.1\|2177771_2178338_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176908
NC_017030.1\|WP_014394682.1\|2201243_2203067_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_017030.1\|WP_014394680.1\|2200038_2200434_+\|GFA-family-protein	unknown	unknown	gnl\|CDD\|226314
NC_017030.1\|WP_014394681.1\|2200506_2201097_+\|NAD-dependent-deacetylase	unknown	unknown	gnl\|CDD\|234777
NC_017030.1\|WP_043321158.1\|2180228_2181620_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|378991
NC_017030.1\|WP_014394664.1\|2178762_2179197_+\|DUF1801-domain-containing-protein	unknown	unknown	gnl\|CDD\|227936
NC_017030.1\|WP_014394678.1\|2195120_2198063_-\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NC_017030.1\|WP_043321160.1\|2192068_2193316_-\|SBBP-repeat-containing-protein	unknown	unknown	gnl\|CDD\|115400

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014394663.1\|2178349_2178766_+\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	3.95383e-11
NC_017030.1\|WP_014394676.1\|2193471_2194386_-\|NmrA-family-NAD(P)-binding-protein	gnl\|CDD\|187561	cd05251, NmrA_like_SDR_a, NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs. NmrA and HSCARG like proteins. NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. HSCARG has been identified as a putative NADP-sensing molecule, and redistributes and restructures in response to NADPH/NADP ratios. Like NmrA, it lacks most of the active site residues of the SDR family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Atypical SDRs are distinct from classical SDRs. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.66567e-55
NC_017030.1\|WP_014394670.1\|2184599_2185505_-\|SMI1/KNR4-family-protein	gnl\|CDD\|378155	pfam09346, SMI1_KNR4, SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.	4.52431e-06
NC_017030.1\|WP_014394677.1\|2194491_2195043_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	8.8078e-10
NC_017030.1\|WP_014394674.1\|2190978_2192001_+\|deoxyhypusine-synthase-family-protein	gnl\|CDD\|224811	COG1899, DYS1, Deoxyhypusine synthase [Posttranslational modification, protein turnover, chaperones].	3.66688e-27
NC_017030.1\|WP_014394669.1\|2182729_2184577_+\|M48-family-metalloprotease	gnl\|CDD\|320687	cd07328, M48_Ste24p_like, M48 Ste24 endopeptidase-like, integral membrane metallopeptidase. This family contains peptidase M48-like proteins that are as yet uncharacterized, but probably function as intracellular, membrane-associated zinc metalloproteases; they all contain the HEXXH Zn-binding motif, which is critical for Ste24p activity. They likely remove the C-terminal three residues of farnesylated proteins proteolytically and are possibly associated with the endoplasmic reticulum and golgi.	5.37161e-27
NC_017030.1\|WP_014394673.1\|2189271_2190150_-\|hypothetical-protein	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	9.74038e-05
NC_017030.1\|WP_014394680.1\|2200038_2200434_+\|GFA-family-protein	gnl\|CDD\|226314	COG3791, COG3791, Uncharacterized conserved protein [Function unknown].	7.93346e-34
NC_017030.1\|WP_014394668.1\|2181722_2182622_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.76013e-09
NC_017030.1\|WP_014394662.1\|2177771_2178338_+\|SRPBCC-family-protein	gnl\|CDD\|176908	cd08899, SRPBCC_CalC_Aha1-like_6, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	4.25618e-35
NC_017030.1\|WP_014394682.1\|2201243_2203067_+\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	3.37537e-50
NC_017030.1\|WP_014394681.1\|2200506_2201097_+\|NAD-dependent-deacetylase	gnl\|CDD\|234777	PRK00481, PRK00481, NAD-dependent deacetylase; Provisional.	3.67106e-41
NC_017030.1\|WP_043321158.1\|2180228_2181620_-\|SH3-domain-containing-protein	gnl\|CDD\|378991	pfam12913, SH3_6, SH3 domain (SH3b1 type). This domain appears to be an SH3 domain of the SH3b1-type, and is just C-terminal to an N-terminal domain that is probably the stabilizing domain for the structure from Desulfovibrio vulgaris DVU_0896, Structure 3m1u, which is a four-domain protein. The next domain is an SH3b2 and the last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, pfam00877 (details derived from TOPSAN).	7.49951e-13
NC_017030.1\|WP_014394664.1\|2178762_2179197_+\|DUF1801-domain-containing-protein	gnl\|CDD\|227936	COG5649, COG5649, Uncharacterized conserved protein [Function unknown].	1.81567e-57
NC_017030.1\|WP_014394678.1\|2195120_2198063_-\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	1.00223e-60
NC_017030.1\|WP_043321160.1\|2192068_2193316_-\|SBBP-repeat-containing-protein	gnl\|CDD\|115400	pfam06739, SBBP, Beta-propeller repeat. This family is related to pfam00400 and is likely to also form a beta-propeller. SBBP stands for Seven Bladed Beta Propeller.	0.000737566

>NC_017030.1|WP_014394671.1|2185599_2187609_-|DNRLRE-domain-containing-protein
MSGKKMWRRMRMSAGWMAGLMLLTHCGGAEESVKDGDTAQETAELDACEAVVQVENLRVVVTEDTYASATAPTATHGGLDRVVVDANPQSEGFLKFNVPQALLQGGVIVRAKLQLNAVDGSSDGPALYQTGTDWSEASLNWNNRPGHASGALLGDQGSIITHQLVEYDVTSVVMEPGTFGFVLVPTSGDGTDFRSSESTGTTLVPRLDLTVAKSVCTRKGTGGDVAWTRVRGGEGFQSFPTRAGGMDAAADGSFVTLAAYNEQGNFGGQTFTSANSFVIAKYAADGSHQWSRAYVPFTPSARLHANAVTLTPLGNILVVGNYNGAPDLGAGPLPPVEDEDDVGLFIAKYSPNGDFVWAHGFAPTGSAQLSQRYVNASRVTSDANGSLLVTGGFVGELNLGGETFVSGTTDSQESLFLAKFSWEGNPLWSLAVPAGTSDLYYDSVSAEDVLTDANGRVFVTGVAGTGRMGATAPSTPFIAAYSPEGALLWSRAFNGATGSLGGLALRPDGSLAFAGAFSGSFSFAGATFTSVPGNSGPSSDAIVGALSASGGDLWVRKHGTGRDESFLDLGVDTAGNITVRAMSNGLFDLGGGPLGHPAEGRHFVARFSASGAHLWSRVMDPDLSMSDMEVLPDGSTLLEGTFRNPVTLNSQEYVAPGGAAELLFLRLTP
>NC_017030.1|WP_014394670.1|2184599_2185505_-|SMI1/KNR4-family-protein
MIDPRFPARLLEDLSQQRSTEGPRTRLNIDRHGDESEELPPGLVPFARDGGGGVWYLDVEDCLKKGVGAIFYLHMSEVYGDTRYIAASYDELLQRVAEGLHPRDMPTFDELASRQAPKSVRVPGIEGLVDVERVHASTGRPAVVTVHDNARCEGGFVARAGTSVYMTDAGRIQFVTLAERAVVDGIPCAGDTVLALHPKTGRPLRFTPAEPIVVDGLPLAPFHEVMVEDPIYAPSVSGMLARDHDVEGLPLAAGTQVRLLRGKLDQGTLRADANVAGTLLPAGTWFELLSGTLYRTRPPAT
>NC_017030.1|WP_014394669.1|2182729_2184577_+|M48-family-metalloprotease
MASSRISAGFVRSLVLPALLLFALPLLGLWFAGHASDRFDAQVLEVIEKQIGRDTTLSEADRQEALAFYREVPASAACQSDSEELASYRDGLGEACSDAKQFGWAYLASWVLLALGLGSTAVALLCGLAAFISRPFQYGSFVVGWFVLRITSALQVLGQGALLVWLSYWVTALWANRYYPKLIGIMALLAAGAVFLVVVAIFSRPPMNFDVEAEEVPEARAPELWACVRRLCARLQTPPPDHILAGIDTNFFVTESDVRVDGRVLTGRTLFVSLSLLRLLERSEAEAVLAHEMGHLLGGDTGHGKRLAPMLSHFGHYLETLRDGGVTLPVFYFMAAYRGLFELSLGRSRRASELAADRLAAGVTSGQDIARSLVKVGAYSSFRDRVEAKLFAQDEQHQSVAISQRVALGFSEYAQSEVVHDDLQGAVTPHPFDSHPPLGARMENVGVQLKPADMAQVLLEPVQSSWVEAFEDAEAIEARLWGAYEARFSQAHDLALACRYGPSTDEERQHVEKFFPALVFEGKEAGYEVRMDYAQVSCSEWEEPVEFERISSASTADRMFKKYLDLKVTGEGRFKGGRSICLSKLKEQDAVLEAFERYLGRHRFMKAHRSDSQAA
>NC_017030.1|WP_014394668.1|2181722_2182622_-|GNAT-family-N-acetyltransferase
MSSLRPYRDVADLEAMEQLVARAWAERGPHVECAVGDLTWRLLRNAQVRPREDIALWEPEPGQLAGFAWAYGNGDVDLLVHPLTHANAFVQDMLPWVRARHGSTSPPATLWALESNGPLLAALQRSGCLRTPGGCYLHLELPLHALPPPPPPLPAGYRVRAVRGLEEVAARALVHRRGFGTERMTTEVYAQLMEAPRYQPALDLVAEAPDGSLAACALGWFDEVNAVGEFEPTACAPEHRRRGLVRALLHEGLGRMHGMGARRAIVYAFEDNPASVALYQSAGFTVVDRNLGHSEPPVK
>NC_017030.1|WP_043321158.1|2180228_2181620_-|SH3-domain-containing-protein
MRALSLAVMGAAASLTACAAPAALAVSPSGVPAFSEDMLTPGFWIRRAPSPDAVLLDAGQVAAKRELAFGPEGGLIDLKGLPATLTRAQVAGWVRAAQQTPIPAVIDEQGQPVTEAMLDGLRQNAAAEHIPEATAARYGLSVRRTHLRSLPSDRRLFASEDSRDYESLQAGILFPGEPVVIAHQSADQQWLFVQTTQGPAWVQRGDIAEGTADAVFSYVAMAPGRVVTGDQVRTVFTPEAPGVSELELDMGVALPRADVAPGEPVNGASSYASWPVQLPVREEDGSLAFRSALLRRTADTAPGYLPLTRANILRQSFKFLGERYGWGHQFNARDCSGLTSEVYRSMGLLLPPNSGMQGKSAALNHRLFTAQDSHEERVRALKQAEVGDLVVVPGHVLMIIGHVNGEPYVIQDVPYAVFKDPATQQVRKTKLNQVSVTPLLPLYADDTTLYVDAMTSLVHVTRP
>NC_017030.1|WP_014394666.1|2179754_2180192_+|hypothetical-protein
MQPERQVVGFIARGAVEDGRLFDSIGRALGLPPEGVARFDVDGPSDAAVLVETALRSKGFRTDVTLYVDVSRTRVSSGLTSVEVATRVAALLGEEVLVSPPADDPAVATSWFLVTPDGKRFRASEVSLEGDEDSLEIDRASLRPA
>NC_017030.1|WP_014394665.1|2179248_2179743_+|hypothetical-protein
MLRPAVRKPFIPLTLATVLMALGVLLIAPNAWAEKPAKPTSKPADRHYIRKVDQSSVAKDKNTVIESRVDVSRDVKDINDGKAKKGSDSGAVTWTLNGRTYGAHDNGTLYPIRGTGFHELNRSAFKALGVYNKFDDTPRAKEILDKMGTSQGDRKAALKAHIAG
>NC_017030.1|WP_014394664.1|2178762_2179197_+|DUF1801-domain-containing-protein
MKKAVAKESASALIDQRIQDLGDWRGKTLAKVRALIHAADPEVVEEWKWMGTPVWSHDGIICTGESYKAAVKLTFLKGAALPDPAGLFNSSLEGNARRAIDIHEGDKINETAFKTLIRAAVVLNLENKSNKPKASRAKRKPAPK
>NC_017030.1|WP_014394663.1|2178349_2178766_+|DoxX-family-protein
MESTLPKPALVAARTSPKAVTITFWIATALFCLEMGFTAYAQLNLQDAADGFTRLGFPGYFRVELAWAKVLGLLVLVAPVPGRLKEWAYAGFAINLVSALIAHFAVGDGPEAWAFAAFTSVLWVVSYVSWRNLQGGRA
>NC_017030.1|WP_014394662.1|2177771_2178338_+|SRPBCC-family-protein
MSHRAKYTPGPAAGARVQKEGEKWTLVLVRDLRHPPAKVWQALTDPAHLAEWAPFDADRNMASVGPVKLSTVGAPTPQVAETTVKRAEAPKLLEYSWGPQDLRWELELTGAGGTRLTLWHNIDRGFIAWGASGWHICFDVLDHLLSGDPLGRIVGPDAMQYDWQRLNSEYAEQFGVQSPTWKASNSKQ
>NC_017030.1|WP_014394673.1|2189271_2190150_-|hypothetical-protein
MTHMPRWFALLPLPAILLGAFVAWRSGVPATAFAVNVLAAALGVGTAALVGRLSSTALPQASVPIAFVAVLLTASTLLFPGLDGVHRWLVLGSVRLHASTLAVPWVLLGMSAALHQRFAVSAGLALGMSAVHALQPDAGQGTAFALAASALLACAPSTPWLLRAASCSGTLVLGFAAWLRPDPLAAVPHVERIVHLAASVAPALGVAAVLALALLLLPAALVTERARASGGQEWALPASLVVYIAATLGVTTLGNFPVPVMGAGAGPILGWYAATGILAAAWATARVSSAAS
>NC_017030.1|WP_014394674.1|2190978_2192001_+|deoxyhypusine-synthase-family-protein
MSTSELPVLEFILTNYKNFNARATRDALLSYWEHVSSGGRMFWSVAGAMSSAQLGITLAPAIRSGLIHGLSVTGANLEESLFRLVAHTAYKDFPEYRYFTKQDDTKILEQRMRRVTDTSIPEDEAFRAVEKIVVPMWKNASAKGERRFWHEYFYELIQVLEPSAYEGDPEACWLMEAAKRKLPIVVPGYEDSTFGNIFASYVKTGDCNASIAKSGIEYMADFYDRYEELSAGTGVGFFQIGGGIAGDFPICVVPSTKYDMQKPVKPWAYFCQISDSTTSYGSYSGATPNEKITWDKLTETTPMFVIESDATIVVPLMLRALLECQGNPDAANALIAKHRR
>NC_017030.1|WP_043321160.1|2192068_2193316_-|SBBP-repeat-containing-protein
MFGFAGVVGAAGLPSVAAAQVPSPSWVAQLGANLDEQANAVAVSGASVYVVGQTTSQLGADPKVGGQDAFIARYDTAGNLQWARQLGTPGNDRATAVATDADGNAYVAGTTYGGFDFYTNAGGFDFFIAKYDAAGNRLWLRQNGTQMDDFATGIAVGADDTLYFTGYTGGSFANGGNPNNYDIIAGLYDTAGNPYWLQQYGTSASDVARGIAVTSGHEVYIVGNTSGSLDGTTSSGNSDLFLLKLNILGVQQWVRQIDAGELDDAKSVAVGPDGGVYIAGETFGSLDGNTNNGTVDVLLARYDSAGNRAWSRMLGGEQPDYAFGVAVTPDNVVQVVGYTSGLDNIPSAGGSDAFLTRYDALGTKVGSRLLGTSRQDIARGVAVDASGNAYVAGQTAGSLGGNTSAGGNDAFLVRF
>NC_017030.1|WP_014394676.1|2193471_2194386_-|NmrA-family-NAD(P)-binding-protein
MSRSETVLVTAATGRQGGATARALLAEGRTKVRVLVRNPEAANARALAAAGAEVVVGDLDDPASLRAACAGTRAVFSMQSPIVSATGIDFSKERQQGRNLVEAALAEGVETFVHTATSGVGAHRDVEGWAEGRWKFHEEYWENKLATCDLVRTAGFKHWTVLLLSTFMDHPMFDPAGFVDGRRLLTVVRADKPLALIAPEDIGKAAAAAIHDPARFHGVTLELAGDVLTLPQITEVLSRVDGKEYVAWSSSIEEAVAAGLHPGVAQGMTYMNVAPLLARPEIARSYGLSPMSFEAWVRQRREMT
>NC_017030.1|WP_014394677.1|2194491_2195043_+|TetR/AcrR-family-transcriptional-regulator
MEQVKRLRADGRRNRERIVEVAAELVAREGAQVSLEEIARRAGVGSATLHRHFPSRQALLEAVFRDGVAQLCARAAAKPGKAPADELADWLEEVTVYTVTHRGLAAALLAGPEGLSAEDICCTDLLLNVVKALVARASSVGALHAGATAEDLVKLVNAIAVANENDPTTARRVLRLALTGIRR
>NC_017030.1|WP_014394678.1|2195120_2198063_-|PQQ-dependent-sugar-dehydrogenase
MPGTSVRAESPLPLFVVCAVFSLLVGCSTQAPLELEVARAAAVMQEPNFADSVFVSGLQGPTTMTFAPDGRLFISEKNGSLRVVVNGQLLSTPFMTLAVDTGNERGLMGVAFDPNFDSNHYLYVYYTSVAGSIHNRVSRFTANGNVVVPGSELVLADFPTLDAANHNGGAVRFGLDGKLYVSVGENAVSSNSQSLNTPLGKLLRFNPDGSIPTDNPFYATATGLAKATWAMGLRNPFTFDVQPGTGILFINDVGEGGWEEINRGQAGANYGWPMTEGYFTNRPELTQPFFAYPHGSGTAAGNCIAGGAFYNPPVTAFPSAYVGQYFFADYTNNWISRIDPNTGAHSLFATAASGPVDLDVGPDGALYYLARGAGQVGRIAYTASLPPSIAQQPASTLVSVGYPATFTVSASGEPPLTYRWQRNGVDIPGATSPGYELTAAQLGDSGARFRVVVTNGLGSTTSTEAVLTVTSNKPPVATILTPATGATYIAATNLTFSGSASDQEDGALPPSAMTWNITFHHDTHTHPAMADTTGIASGSWPIPNIGESSANVWYRVRLTVRDSIGLTHTTYRDVHPVTVPLTVTSVPSGLQVLMDGRPVPAPHDTTGVVGVVRSVGVESPQYANGKFWAFSSWSDGGAQSHTFITPGSAATYTALFVETSGGSCYQIQSERSDKWLTVDTAGKVVAGSTTQAGGQIFQLVPNGTQYKLKGSGDAFLTVVANQLTMGANFTSGESFTQLACGYGGRTRVGFRASVGSAPHWKETTTGGPIQSGDGGNGGACNPADGGAWEGFYLEPVACPGSGGGPVCGNGTVESGEQCDDGNTQPGDGCDATCQTEASGSAGCFRIQSERTDQWLTVDGAGKVAALGTTQAGGAVFELVTSGAKYKLKGASGAYLAVVADQLTVNASLGTAEAFTRHACGVFGGRNRYGFEATTGTARNWKENTPGAPIQSGNGGNVGICNPADATSWEAFYLEPATCPQ
>NC_017030.1|WP_014394679.1|2198221_2200018_+|hypothetical-protein
MDGISRFSSALNGVRTSSVSETASQPTPSQDSTAERTLRELFSRSSFEPSSRPAATSSYRALSQPTAPPDVSNPSVSDWQAWCEQFKGNAEAELNRKRGTTLPDVTADQVMHGSHSPMYAAGRSTVPGNENIPAFFQDFPATGERQMQLYTFCRPPPGQTLDPTDRNQWVSFEVHGDLCKAYSDNTFTHGRQGTNSLLGYPNSGLEDGVKARPPFLDDPMVKAFRDARVAAGKPDMVPFQEFQNGYLVDLGGKVQAFSKDGQRLGTAWPGGDMTATATQGPGGVQTPTGPYGTTGPLNGDTSFGNATVQMGTSASHGGAVTSLVYDGKEYINNKDHGRQMQVAFSLDGYDEALMPTEAGSHQNGADPISTTEVVGYGAQPGRMTSSVHPAYWLEPGEEAGPYNSVPKAKNTTLVSEDVITKDITVGVGGHDNVIQYDSHIHLAASHDKIYAEVPTTYVNGEFEKHYRFDPATGESREYPRVHSEPPKPPEERKGFPDEGGNVPLIVATGDGKHAMAIWSPDERRSDLQYRLHQFDLGNPADDCTKLGVTFGMSEDVPADIQTRSYVIVGTVEEVKARLAELYSQNPTGVERKWPEDVR
>NC_017030.1|WP_014394680.1|2200038_2200434_+|GFA-family-protein
MHRGSCLCGAVRFTVEGELPAPDACHCGKCRKHSGHYFVSTDVPRSAVTIEGADKVGWFQSSEKARRGFCSVCGSSLFWDPLHRDWIGIAMGAFDTPTHTRIAVHVYMANKGDYYDVADGVRQFDTIPPRP
>NC_017030.1|WP_014394681.1|2200506_2201097_+|NAD-dependent-deacetylase
MALAAKPNPAHLALAQWERWQEQRGRAFTLVTQNVDTLHEQAGSRALIKVHGSLDRARCTKRGCENGAPRGSVPLASVDFGPFHAFPSPRTVPRCPRCNKRMRPHIPWFDEFYAEHQDYGIQRVEERAKRSRLVLFIGTSFSVGVTDRVSTLALLREAKVLSIDPSGTSRVPGIEVIPERAEELLPRWIQALTESP
>NC_017030.1|WP_014394682.1|2201243_2203067_+|serine-hydrolase
MLRLVPLWVFVLLVPTLALATDAPAPTTAAELRQSLTALLDTHHIPGASYAVFDREGTVLRGTIGLTDSGTRAPVTDDTLFRLGSITKTVTAIAIMQLVEQGHFDLQTPVSRLLPDAPIQNPFNDTDPVRVIHLLTHTAGFDDMHAKAFFSPVERRGRHLESSLQHPEPLVVRWRPGVYEGYSNPGYVLLGAILEAHYQQPWDEVVSARVLGPLGITRFATLATQAARGDHASGHTGDDMHRTPVFFEQTQADGALWCTAEDLARLGRFLLTDGATAPGVLRPETVRAMKQTGATVGTRAGGVYGSRLGLQHRIVAGMLWLGHSGGLLGGKASMHFHAEQGLGYVLLLNSENEIRKLEVPLAAFISQRTRWKPPAPTLRPVEGDVDGWYRVVNPRISLAGLPTYLLHASRVRAQGDTLTIEPFLPGFGYQATLKHHGNGLLSDIDYGDVVNGVLVRDGNGAAVGIETGGDFLERTSMVAAVLPLVSVLLSLVLLVSTPFGRRTSLRNRWMRRLPSLALLTLVLGIVCAANLELTLLAHKNWQTVGVWAASVLFPALGVAGVVLSVRTWRQEPAALARWRCLLGSASVVCLSTWLATFGMFSFALWRW

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Crispr_ID: NC_017030_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_10

2472609-2473740

Orphan

Consensus_repeat	Method
AACCTGTCGGACAGTCGGACAGGTTT	CRISPRCasFinder
TGTCGGACAGTCGGACAGGTT	CRT
AACCTGTCGGACAGTCGGACAGGTTT	CRISPRCasFinder
TGTCGGACAGTCGGACAGGTT	PILER-CR

16 spacers

The CRISPR arrays of NC_017030_10

>merge|NC_017030|10|2472609-2473740|CRISPRCasFinder,CRT,CRISPRCasFinder,PILER-CR
AACCTGTCCGACAGCCGGGCAGGTTCGGACGACCGTGGAGGGAGGCCTCCGGGCCAGCCAGGCACCGGAAACCTGTCGGACAGTCGGACAGGTTCTGGAGAACCGGGGCCAGGGCCCTCGTCCCGTCGGACCGGCGGAAACCTGTCGGACAGTCGGACAGGTTCGAAGGACCGTGGCTGGGGGCGGCCGATCCATCCGGGCAGCGGAAACCGGTCGGACAGTCGGACAGGTTCGATGGAACCGGGGCCAGGGCCCTCGTTCCTCCCAAGCGGAGGAAACCTGTCGGACCGTCGGACGGATTGGGAGAACCGGAGTTGGGGGCTTCGTTCTGCCCGAGCCACGAGAACTTGTCGGACCGTCGGACGGATTTGGAGAACCGGGGCCAGGGGCTTTGCTCCGCCCGAGCCGCGAAACCCTGTCGGACCGTCGGACAGGTTTGGTGGACCGTCTCTGGGGGCTCCGGGCCAGCAGTCGCCGGAAACCTGTCGGACAGTCGAACAGGTTTTGGAGAACCGCAGCAGGGGCTGCCGCCCAATTCAGGCTGCGGAAGCCTGTCGGACAGGTTCTGGGGAACCGGGGCCCGGAACCTCTTCCTGCCCGAGCCGCAAAAACCTGTCGGACAATCGGACAGGTTCGAGGGACTGGGCTGGGGCAGCCGTTCCATCCGGACCCCAGAATCTTGTCGGACAGTCGGGCAGGGCTTGGAGAACAGTGGTTGGGAACTACCGCTCCAACTGGGTCCCAAGAAGACCTGTCGGACAGTCGGACAGGTTTTGGGCCCACTGCGGCCGGAAGGTCGTCGTTCCGTCCGGGCAGCGGAAACCTGTCGGACAGTCGGACAGGTTTGGCCGTCCTGCGGCTGGGGGCTCCTCGTTCCATCCGGGCAGCGGAAACCTGTCGGACAGTCGGACAGGTTTTGGGCCCACTGCGGCCGGGAGGCCGTCGTTCCATCCGGGCAGCGGAAACCTGTCGGACAGTCGGACAGGTTTGGCCGTCCTGCGGCTGGAGGCTGCTCACTCCCGACGGGCAGAGGGAACTTGTCGGACAGTCGGACAGGTTTTGGAGCGCCGTCGCTGGAGGGGCTGCCCGCTCCCGTCGGGCTGCGGAATCTTGTCGGACAGGTTTGGGCTGT

>NC_017030|10|7|2472609-2473114|CRISPRCasFinder
AACCTGTCCGACAGCCGGGCAGGTTC	GGACGACCGTGGAGGGAGGCCTCCGGGCCAGCCAGGCACCGGA
AACCTGTCGGACAGTCGGACAGGTTC	TGGAGAACCGGGGCCAGGGCCCTCGTCCCGTCGGACCGGCGGA
AACCTGTCGGACAGTCGGACAGGTTC	GAAGGACCGTGGCTGGGGGCGGCCGATCCATCCGGGCAGCGGA
AACCGGTCGGACAGTCGGACAGGTTC	GATGGAACCGGGGCCAGGGCCCTCGTTCCTCCCAAGCGGAGGA
AACCTGTCGGACCGTCGGACGGATTG	GGAGAACCGGAGTTGGGGGCTTCGTTCTGCCCGAGCCACGAG
AACTTGTCGGACCGTCGGACGGATTT	GGAGAACCGGGGCCAGGGGCTTTGCTCCGCCCGAGCCGCGAA
ACCCTGTCGGACCGTCGGACAGGTTT	GGTGGACCGTCTCTGGGGGCTCCGGGCCAGCAGTCGCCGGA
AACCTGTCGGACAGTCGAACAGGTTTTGGAGAACCGCAGCAGGGGCTGCCGCCCAATTCAGGCTGCGGAAGCCTGTCGGACAGGTTCTGGGGAACCGGGGCCCGGAACCTCTTCCTGCCCGAGCCGCAAAAACCTGTCGGACAATCGGACAGGTTC	GAGGGACTGGGCTGGGGCAGCCGTTCCATCCGGACCCCAGA
ATCTTGTCGGACAGTCGGGCAGGGCT	TGGAGAACAGTGGTTGGGAACTACCGCTCCAACTGGGTCCCAAGAA
GACCTGTCGGACAGTCGGACAGGTTT	TGGGCCCACTGCGGCCGGAAGGTCGTCGTTCCGTCCGGGCAGCGGA
AACCTGTCGGACAGTCGGACAGGTTT	GGCCGTCCTGCGGCTGGGGGCTCCTCGTTCCATCCGGGCAGCGGA
AACCTGTCGGACAGTCGGACAGGTTT	TGGGCCCACTGCGGCCGGGAGGCCGTCGTTCCATCCGGGCAGCGGA
AACCTGTCGGACAGTCGGACAGGTTT	GGCCGTCCTGCGGCTGGAGGCTGCTCACTCCCGACGGGCAGAGGG


>NC_017030|10|3|2472613-2473740|CRT
TGTCCGACAGCCGGGCAGGTT	CGGACGACCGTGGAGGGAGGCCTCCGGGCCAGCCAGGCACCGGAAACC
TGTCGGACAGTCGGACAGGTT	CTGGAGAACCGGGGCCAGGGCCCTCGTCCCGTCGGACCGGCGGAAACC
TGTCGGACAGTCGGACAGGTT	CGAAGGACCGTGGCTGGGGGCGGCCGATCCATCCGGGCAGCGGAAACC
GGTCGGACAGTCGGACAGGTT	CGATGGAACCGGGGCCAGGGCCCTCGTTCCTCCCAAGCGGAGGAAACC
TGTCGGACCGTCGGACGGATT	GGGAGAACCGGAGTTGGGGGCTTCGTTCTGCCCGAGCCACGAGAACT
TGTCGGACCGTCGGACGGATT	TGGAGAACCGGGGCCAGGGGCTTTGCTCCGCCCGAGCCGCGAAACCC
TGTCGGACCGTCGGACAGGTT	TGGTGGACCGTCTCTGGGGGCTCCGGGCCAGCAGTCGCCGGAAACC
TGTCGGACAGTCGAACAGGTT	TTGGAGAACCGCAGCAGGGGCTGCCGCCCAATTCAGGCTGCGGAAGCC
TGTCGGACAGGTTCTGGGGAA	CCGGGGCCCGGAACCTCTTCCTGCCCGAGCCGCAAAAACC
TGTCGGACAATCGGACAGGTT	CGAGGGACTGGGCTGGGGCAGCCGTTCCATCCGGACCCCAGAATCT
TGTCGGACAGTCGGGCAGGGC	TTGGAGAACAGTGGTTGGGAACTACCGCTCCAACTGGGTCCCAAGAAGACC
TGTCGGACAGTCGGACAGGTT	TTGGGCCCACTGCGGCCGGAAGGTCGTCGTTCCGTCCGGGCAGCGGAAACC
TGTCGGACAGTCGGACAGGTT	TGGCCGTCCTGCGGCTGGGGGCTCCTCGTTCCATCCGGGCAGCGGAAACC
TGTCGGACAGTCGGACAGGTT	TTGGGCCCACTGCGGCCGGGAGGCCGTCGTTCCATCCGGGCAGCGGAAACC
TGTCGGACAGTCGGACAGGTT	TGGCCGTCCTGCGGCTGGAGGCTGCTCACTCCCGACGGGCAGAGGGAACT
TGTCGGACAGTCGGACAGGTT	TTGGAGCGCCGTCGCTGGAGGGGCTGCCCGCTCCCGTCGGGCTGCGGAATCT
TGTCGGACAGGTTTGGGCTGT

>NC_017030|10|8|2473218-2473668|CRISPRCasFinder
	GGACGACCGTGGAGGGAGGCCTCCGGGCCAGCCAGGCACCGGA
AACCTGTCGGACAGTCGGACAGGTTC	TGGAGAACCGGGGCCAGGGCCCTCGTCCCGTCGGACCGGCGGA
AACCTGTCGGACAGTCGGACAGGTTC	GAAGGACCGTGGCTGGGGGCGGCCGATCCATCCGGGCAGCGGA
AACCGGTCGGACAGTCGGACAGGTTC	GATGGAACCGGGGCCAGGGCCCTCGTTCCTCCCAAGCGGAGGA
AACCTGTCGGACCGTCGGACGGATTG	GGAGAACCGGAGTTGGGGGCTTCGTTCTGCCCGAGCCACGAG
AACTTGTCGGACCGTCGGACGGATTT	GGAGAACCGGGGCCAGGGGCTTTGCTCCGCCCGAGCCGCGAA
ACCCTGTCGGACCGTCGGACAGGTTT	GGTGGACCGTCTCTGGGGGCTCCGGGCCAGCAGTCGCCGGA
AACCTGTCGGACAGTCGAACAGGTTTTGGAGAACCGCAGCAGGGGCTGCCGCCCAATTCAGGCTGCGGAAGCCTGTCGGACAGGTTCTGGGGAACCGGGGCCCGGAACCTCTTCCTGCCCGAGCCGCAAAAACCTGTCGGACAATCGGACAGGTTC	GAGGGACTGGGCTGGGGCAGCCGTTCCATCCGGACCCCAGA
ATCTTGTCGGACAGTCGGGCAGGGCT	TGGAGAACAGTGGTTGGGAACTACCGCTCCAACTGGGTCCCAAGAA
GACCTGTCGGACAGTCGGACAGGTTT	TGGGCCCACTGCGGCCGGAAGGTCGTCGTTCCGTCCGGGCAGCGGA
AACCTGTCGGACAGTCGGACAGGTTT	GGCCGTCCTGCGGCTGGGGGCTCCTCGTTCCATCCGGGCAGCGGA
AACCTGTCGGACAGTCGGACAGGTTT	TGGGCCCACTGCGGCCGGGAGGCCGTCGTTCCATCCGGGCAGCGGA
AACCTGTCGGACAGTCGGACAGGTTT	GGCCGTCCTGCGGCTGGAGGCTGCTCACTCCCGACGGGCAGAGGG
AACTTGTCGGACAGTCGGACAGGTTT

>NC_017030|10|3|2473222-2473667|PILER-CR
TGTCGGACAATCGGACAGGTT	CGAGGGACTGGGCTGGGGCAGCCGTTCCATCCGGACCCCAGAATCT
TGTCGGACAGTCGGGCAGGGC	TTGGAGAACAGTGGTTGGGAACTACCGCTCCAACTGGGTCCCAAGAAGACC
TGTCGGACAGTCGGACAGGTT	TTGGGCCCACTGCGGCCGGAAGGTCGTCGTTCCGTCCGGGCAGCGGAAACC
TGTCGGACAGTCGGACAGGTT	TGGCCGTCCTGCGGCTGGGGGCTCCTCGTTCCATCCGGGCAGCGGAAACC
TGTCGGACAGTCGGACAGGTT	TTGGGCCCACTGCGGCCGGGAGGCCGTCGTTCCATCCGGGCAGCGGAAACC
TGTCGGACAGTCGGACAGGTT	TGGCCGTCCTGCGGCTGGAGGCTGCTCACTCCCGACGGGCAGAGGGAACT
TGTCGGACAGTCGGACAGGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014394900.1\|2470689_2471535_+\|phage-major-capsid-protein	unknown	unknown	gnl\|CDD\|273690
NC_017030.1\|WP_014394904.1\|2475706_2476783_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|235299
NC_017030.1\|WP_014394910.1\|2482189_2482711_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_017030.1\|WP_014394909.1\|2481138_2482179_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394893.1\|2464420_2464684_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237054
NC_017030.1\|WP_014394895.1\|2466569_2467517_+\|putative-transketolase-N-terminal-section	unknown	unknown	gnl\|CDD\|238970
NC_017030.1\|WP_014394903.1\|2474850_2475720_+\|[LysW]-aminoadipate-kinase	unknown	unknown	gnl\|CDD\|237599
NC_017030.1\|WP_014394905.1\|2476787_2478023_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_017030.1\|WP_014394894.1\|2464703_2466371_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|171961
NC_017030.1\|WP_014394898.1\|2468765_2469620_+\|RimK-family-alpha-L-glutamate-ligase	unknown	unknown	gnl\|CDD\|273994
NC_017030.1\|WP_014394901.1\|2471534_2472530_+\|sulfotransferase	unknown	unknown	gnl\|CDD\|379204
NC_017030.1\|WP_148282517.1\|2468576_2468756_+\|lysine-biosynthesis-protein-LysW	unknown	unknown	gnl\|CDD\|273499
NC_017030.1\|WP_052312976.1\|2451542_2464289_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NC_017030.1\|WP_014394902.1\|2474077_2474854_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187602
NC_017030.1\|WP_014394911.1\|2482720_2486650_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014394908.1\|2480704_2480992_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394906.1\|2478122_2479049_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_017030.1\|WP_014394899.1\|2469616_2470660_+\|N-acetyl-gamma-glutamyl-phosphate-reductase	unknown	unknown	gnl\|CDD\|234761
NC_017030.1\|WP_014394896.1\|2467513_2468551_+\|putative-transketolase-C-terminal-section	unknown	unknown	gnl\|CDD\|226467
NC_017030.1\|WP_014394907.1\|2479102_2480608_+\|putative-metal-binding-motif-containing-protein	unknown	unknown	gnl\|CDD\|338048

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014394900.1\|2470689_2471535_+\|phage-major-capsid-protein	gnl\|CDD\|273690	TIGR01554, prophage_Lp3_protein_18, phage major capsid protein, HK97 family. This model family represents the major capsid protein component of the heads (capsids) of bacteriophage HK97, phi-105, P27, and related phage. This model represents one of several analogous families lacking detectable sequence similarity. The gene encoding this component is typically located in an operon encoding the small and large terminase subunits, the portal protein and the prohead or maturation protease. [Mobile and extrachromosomal element functions, Prophage functions].	0.00607173
NC_017030.1\|WP_014394904.1\|2475706_2476783_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|235299	PRK04443, PRK04443, [LysW]-lysine hydrolase.	2.62694e-117
NC_017030.1\|WP_014394910.1\|2482189_2482711_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.39989e-27
NC_017030.1\|WP_014394893.1\|2464420_2464684_-\|hypothetical-protein	gnl\|CDD\|237054	PRK12316, PRK12316, peptide synthase; Provisional.	8.30701e-13
NC_017030.1\|WP_014394895.1\|2466569_2467517_+\|putative-transketolase-N-terminal-section	gnl\|CDD\|238970	cd02012, TPP_TK, Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.	1.40334e-96
NC_017030.1\|WP_014394903.1\|2474850_2475720_+\|[LysW]-aminoadipate-kinase	gnl\|CDD\|237599	PRK14058, PRK14058, [LysW]-aminoadipate/[LysW]-glutamate kinase.	9.03127e-70
NC_017030.1\|WP_014394905.1\|2476787_2478023_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.84851e-54
NC_017030.1\|WP_014394894.1\|2464703_2466371_-\|AMP-binding-protein	gnl\|CDD\|171961	PRK13295, PRK13295, cyclohexanecarboxylate-CoA ligase; Reviewed.	0
NC_017030.1\|WP_014394898.1\|2468765_2469620_+\|RimK-family-alpha-L-glutamate-ligase	gnl\|CDD\|273994	TIGR02144, lysine_biosynthesis_enzyme, Lysine biosynthesis enzyme LysX. The family of proteins found in this equivalog include the characterized LysX from Thermus thermophilus, which is part of a well-organized lysine biosynthesis gene cluster. LysX is believed to carry out an ATP-dependent acylation of the amino group of alpha-aminoadipate in the prokaryotic version of the fungal AAA lysine biosynthesis pathway. No species having a sequence in this equivalog contains the elements of the more common diaminopimelate lysine biosythesis pathway, and none has been shown to be a lysine auxotroph. These sequences have mainly recieved the name of the related enzyme, "ribosomal protein S6 modification protein RimK". RimK has been characterized in E. coli, and acts by ATP-dependent condensation of S6 with glutamate residues.	3.69456e-81
NC_017030.1\|WP_014394901.1\|2471534_2472530_+\|sulfotransferase	gnl\|CDD\|379204	pfam13469, Sulfotransfer_3, Sulfotransferase family.	1.50832e-06
NC_017030.1\|WP_148282517.1\|2468576_2468756_+\|lysine-biosynthesis-protein-LysW	gnl\|CDD\|273499	TIGR01206, lysW, lysine biosynthesis protein LysW. This very small, poorly characterized protein has been shown essential in Thermus thermophilus for an unusual pathway of Lys biosynthesis from aspartate by way of alpha-aminoadipate (AAA) rather than diaminopimelate. It is found also in Deinococcus radiodurans and Pyrococcus horikoshii, which appear to share the AAA pathway. [Amino acid biosynthesis, Aspartate family].	6.95042e-10
NC_017030.1\|WP_052312976.1\|2451542_2464289_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NC_017030.1\|WP_014394902.1\|2474077_2474854_+\|SDR-family-oxidoreductase	gnl\|CDD\|187602	cd05344, BKR_like_SDR_like, putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR. This subgroup resembles the SDR family, but does not have a perfect match to the NAD-binding motif or the catalytic tetrad characteristic of the SDRs. It includes the SDRs, Q9HYA2 from Pseudomonas aeruginosa PAO1 and APE0912 from Aeropyrum pernix K1. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.81776e-68
NC_017030.1\|WP_014394911.1\|2482720_2486650_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.18751e-85
NC_017030.1\|WP_014394906.1\|2478122_2479049_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	5.04117e-74
NC_017030.1\|WP_014394899.1\|2469616_2470660_+\|N-acetyl-gamma-glutamyl-phosphate-reductase	gnl\|CDD\|234761	PRK00436, argC, N-acetyl-gamma-glutamyl-phosphate reductase; Validated.	3.46355e-135
NC_017030.1\|WP_014394896.1\|2467513_2468551_+\|putative-transketolase-C-terminal-section	gnl\|CDD\|226467	COG3958, COG3958, Transketolase, C-terminal subunit [Carbohydrate transport and metabolism].	6.55895e-98
NC_017030.1\|WP_014394907.1\|2479102_2480608_+\|putative-metal-binding-motif-containing-protein	gnl\|CDD\|338048	pfam11617, Cu-binding_MopE, Putative metal-binding motif. The seqeunce of structure 2vov is not matched in any other sequence either in UniProt or in NCBI (Sep2014). The model is of a short repeat not found on the G1UBC6 - 2vov - protein. The presence of conserved cysteine residues and the lack of hydrophobic residues suggests that this repeat might be a metal-binding site, perhaps for zinc or calcium ions.	0.00718396

>NC_017030.1|WP_014394901.1|2471534_2472530_+|sulfotransferase
MATASAKGEGAQLTVLYITGWCRSGSTILGNVLNEVPGFFHVGELSFLWKNAYGNGSNTLCGCGQQLLECGIWDTVLTSDVPAGLTPRAHAEEVVRRQQAAVRTRHTLRVLDEAGDSQALHAHADFLARTYRTIARATGSTVLVDSGKFPSEAALLPRVEGIRPLYLHLVRDPRAVTHSWTKTKQYVVPMSAARSTAYWLGFNAASEEVTRRFPAQSLFLRYEDFIAAPDRAVDTVLDLVGVPRAQNPVKGRTVVLGKNHTVTGNPDRFRSGPTLLRGEDDAWKGELASGAKALTVALAWPLMAKYGYFSGARRAPSGGSGPDAAGVETRP
>NC_017030.1|WP_014394900.1|2470689_2471535_+|phage-major-capsid-protein
MSLSTKSPGEVFAAAVQKQGTKAHVDYDTSIVDAFPGFKRRPRIAVRGMFKTAKAERDPVPFWYETHPQTKPTGPVQDVELRPEAGFEFHQDTQALKPTRAWIQVPRNLLEDSQSLAQFIDFRLLVRLNTAENQALCIGKGGDGVRGLLHTPGIVRLPAKKNAVASLLNACAQVEQMGGSADGIVINSLDFYEHLVGQQSLLSDLAAMGIRLCRTRMVNPGTIIVGDFTAAATLYDSQRSVIRFAEPPPGIFPREGLAAYGEVYTTLAVHLPTHFFVASLT
>NC_017030.1|WP_014394899.1|2469616_2470660_+|N-acetyl-gamma-glutamyl-phosphate-reductase
MSVRVAVLGAAGYTGGEVLRLLLAHPAVEVVQATSGQFAGKRLDFPHPHLRGVGTLRYTPHDALEPCDVLVSCLPQGELLQRWAKVARLAERVVDLSADFRLDAAGHARWYGKHPRPDDVPAFVYGLPEWMGDALTNARHVAVPGCMAHAGLLALLPLLHAGLARPDVLVVDAKTGSSGGGSTPDRSSHHPERANALRCYKPVGHRHTGELEGVVARVTGQQPTIHFSATAVPGVRGILATVHAFAARPVEEAEVVRAIATRYREKPFVRLLRPSASLSPFPEPGPLLGTNHCDLSVDVDAERGRIVVNAAIDNLVKGAAGTAVHALNLMLGRPETEGLGFRGLHPL
>NC_017030.1|WP_014394898.1|2468765_2469620_+|RimK-family-alpha-L-glutamate-ligase
MRKVDLVYTRVRTEEKLLLEALRRRDCAVNLVQDSGMVLSMDRQRVTEADTVLMRSMSFTRARYLATFLEMKGLRVLNSARTISLCGDKALTSAALAAKGVPMPWSFVAFDEDACLEAIEQKGYPVVTKPVLGSWGRMVARLDSRTAAEGVLSTRFGTGGAQDHVALVQEYVDKPGYDLRVYVIGRAVGGLRRRSEHWITNTARGAVPERYEVPVVHAKLAEAAAEAVGGDMVAVDLLETRGGDIYVNEINHCVEFARSIDETNVPLPDLIAEYVASGAGGARR
>NC_017030.1|WP_148282517.1|2468576_2468756_+|lysine-biosynthesis-protein-LysW
MTQSVPSEQCPLCAQPVPGGNRIVGEVLSCDGCSAELEVVGINPLRLEEAPEVEEDWGE
>NC_017030.1|WP_014394896.1|2467513_2468551_+|putative-transketolase-C-terminal-section
MSASLAPAVDLAHAPEAWLAAHPELSSRLVFRHAAAHFAQDDARVVFLEADLGGGGDPFEKRHPQRYFNLGICEATMLDMACGLAHGGHTVIAHSFAAFGVMRACEQVRLNLAYARANVKLVCDYGGVAGAFFGPTHHAIEDLAVLRAMPNLTVVSPADGLETVQATRAMLQHDGPVYLRLGRNRVTRLDLPRPPFELGRAALLREGDDVGLLAHGEVGVSVALDAAKLLEAQGVSARVLNVHTLKPLDEESVRETAARTRLLVTVEEHNVLGGLGSAVCETVCSLDLQRRVLRVGLQDRYDSRAGSHEALLRGHGLEGGQVAERILGVLPRTPVFAVESATRRD
>NC_017030.1|WP_014394895.1|2466569_2467517_+|putative-transketolase-N-terminal-section
MTFSANPTTPGLSRDARTPEEPAASGGPVAAARTGDGAAGAASDAGLALLPRRAKAIRRTIVRLAATPSGCHLGGSLSMVEILVALLGRVMRVDPRAPKAPERDHLILSKGHAAAGLYAALAEFGFVDVETLVREYNADGSIFTGHVNAAVPGVEFATGSLGHGLGLGVGLTLAHVLRGEPNRTFVVCGDGEMGEGSNWEALQVASHRKLTGLTLIIDRNGGQNDGPTESILSQEALVQRLDAFGFQSLEVDGHDLPALVAALEAPVVGDRPRAIVARTQKGAGVPMLKGKGPHYAVFSPEHLRRALASLGEDGQ
>NC_017030.1|WP_014394894.1|2464703_2466371_-|AMP-binding-protein
MGQRFHNAAALEKGSEYRRKGWWRDTTVVDDLRRCVQAHPDKTAIIAARYFSKDITRLSYAELARYMDRFALGLRELGVGREDIVAVQLPNGWHFTALALACARLGAVIAPIPPDYRRREVEFILGRTEASVYVGPTSWTGHSHRDMARDIAAVLPSLRHRVLLGSNTELQPGERDFERHFIEHEWEKEASLTGIAPAAADDVCNILYTSGTTGEPKGVVHSHNTNYGITRALCDTLGIDATDVVALPSLLTASTGFTYSYLMPILLGATAIYMDVGDPELTLKLFEEHGVTFTYGIPTYLMNLIALQRKRQRNTSSLRQLATGSIPVPPHLIAAVREVFGVRLHTLWGMTENGAVTITRHEDAPDWPSQSDGRAVAWMETKIVPALAEDGTPYPDGTGRLLVRGASQCLTYFKRDDVYAAAVDAEGWFDTGDLARDDGRGGIRIVGRLKDVIFRYGYKIPVVEVESALYSHPKVKEVAVVAHSDDKIGGERVCAVVVVREGEAPPTLNELRDHLKQQGMSNQYWPDRLDLIDEMPKTATGKVRKYLLRERLKPA
>NC_017030.1|WP_014394893.1|2464420_2464684_-|hypothetical-protein
MNPSPEEAASLTDTEAKLAAWWKDLLGVEVVRPEDHFLEIGGNSLMATVLSNRIESELGVEVSMVELFNTLRAVATLCDELRQEQTA
>NC_017030.1|WP_052312976.1|2451542_2464289_-|non-ribosomal-peptide-synthetase
MQPVPRDVLLPLSFGQQRMWFIEQLTPGGISYNVPYFARLTGALDIPALERALAVLVERHEALRTTFTVVEGQPVQRIAPSLPLPLRVESLEAVPASEREQALRQAAEAEARVPFDLGAGPLMRVRLLRLGEAEHVLLLMLHHICCDGWSLTVMERELQALYAAFRAGTTPVLPPLPVQYADHAVWQRQWIQGEHLQQQLEWWRGELAGAPAALELPTDRPRPAAQSTRGAVYRHALPPGLGKALEALCRKQGVTLFMALLGGMHLLLSRLSGQDDLVIGSPISGRTRQELEPLIGFFINTLPLRVRGEGSLGFGELLRRVRKTCLDAYAHQEVPFEQLVDALQPERDLSRPPLFQVFFTLQHSAVPALELEGLRTSELDFEPGVSRMDLTVFLRETPEGLVGLWEYSTDLFDAATVARFAEHYTRLLEAAVAEPERPVATLPLLTAQERRHLLDQGTGAAVPYPRDASLPALFAEQAARTPGAVAVEAGGLRLTYAELEARANQLAHHLRGLGVRLGTPVGLCSGRSLEMVVATLAILKAGGAYVPLDPGYPPERLELMARDARITVLLLEQGRESSLKGLASRVVVLDPSWRAFEDQPRAAPDVQVPAEALAYVMYTSGSTGRPKGVGVPHRAVTRLVKGVSYVRFGAEDVVLQLATTSFDAATLELWGALLGGAKLFLYPPVTPSLEELEATLERERISVLFLTTAFFEQMALNRPAALARVGQVLTGGDVLSPLAARKLLDAGRAVINGYGPTENTTFSATYQVKRDLDARMPVPIGRPLENSQALVLDARLEPVPPGVVGDLYVGGDGLAWGYLHRPDLTADRFVPHPFSGVPGARLYRTGDRARWLPSGELAFMGRADTQVKLRGFRIELGEIETALRHLPGVEDAVAEVREYAPGDKRLVAYVTGESVDVNALRSRLSAQLPAPLVPSAFVKLDRLPLTPVGKVDRRALATPVGDALVEDAYVAPVTPTETAVAEVWAALLGRTRVGTQDSFFELGGHSLLATQVTSRLRETFQVDLSVRALFEAPTVTSLAARIDALRRESSRIQSLPLVPGPRDGWLPQSFAQQRLWFISQLDTLGYSYNVPMVTRLRGPLDADALERSLAEVIRRHAVLRTTFDEVDGQPVQRIGPAWDFTLTKTDVEAAKLPEQLAMEARRPFELRRGPLLRGLLLRVADDDHVLMLVIHHIVFDGWSIDVLQRELNALYPARGQSTLPPLSLQYVDYARWQRESFQGEELEDQLAWWREALAGAPPVLDLPTDKPRPPVQTFQGANFEVLLPQPLHGSLQLLGQREGATLFMTLLAGFQALLARYSGQEDVVVGSPISGRNRREVEGLIGFFVNTLALRANVSGSRSFRQLLRGVRESCLGAFAHQDLPFEQLVDALKPPRDLSRTPLVQTMFVLQRAATPLSLPGLAVEDFPFQSGVSRFDLMLFMRQTPHGLVAYWEYNSALFEEATLARMAGHYVRLLEAVTANPELPLADLSLLSREEREQLLVAWNNREERLPAPGLIHAWVEAQVARTPEAIAVTSGAESLTYAQLNARANQLAHHLIALGVTPGSSVGLCLERSSLDMPVAVLATLKAGAAYVPLDPNYPTERLALMVEDTRAPVVLAHEGFVRALPPGTSARIVTMETVSLAARPTTSPNVKLSPEAVCYVVFTSGSTGRPKGIAMSHRGISNMLAWQTRRAVRAQATTLQFASLNFDVSFQEIFGTWCIGGRLLLSSAELRRDPPALLRYLTQHRVERLFLPFVALQSLSEAARTATELPPLNEVITAGEQLQVTPALVAFFERLPGCVLENQYGPSETHAVSAWRASGAPSTWAALPPVGTPLPSVQAYVLDPRREPCPVGVPGELYVGGEGLAHGYHGRPDLTAERFVPSPFGPTPGARLYRTGDKARWLADGQLEFLGRLDGQVKLRGFRVEMGEVESALRALPDVRDVVVVLREDTPGHRRLVAYVVQPEASFSPEALRQALARRLPEHMVPSALVRMDALPLGPSGKVNRNGLPAPKEEATDDTGFLAPMTAVEKVIADIWASLLVVPRVGLQDHFFELGGHSLLATQVVSRLREAFQVDLSLRVVFEAPTVAQLAARLEEQLHGANRKAIPPLVPQLRGELVPQSFSQQRLWFVSQLDTSAHAYNLPLVTRLRGRLDAQALEDALNALIRRHEVLRTTFDEVDGQPVQRIGPAWKLTLKQVDVDPRLPLQRQVEAEAHVPFDLRRGPLLRATLLRIADEDQVLILNFHHSVFDGWSIALLQRELDVLYLARLQGTEAVLPPISIQYADHALWQRAWLQGDMLEEQLAWWREQLAGAPPVLDLPTDKPRPPVQTFQGAYIEVPLPPALTSALVAMGQREGTTLFMTLLAGFQALLARYSGQDDVVVGSPISGRNRREVEGLLGLFVNTLALRADVTGSRSFRHLLRGVRESCLGAFAHQDLPFEQLVEALKPPRDLSRAPLVQTLFVLQQAAVPFSLPGLQAEDVPFQTGVSRFDLMLFVRESEQGLTAFWEYNTALFEEATLTRMAGHYVRLLQGAVRHPEQPLSALPLLSEEERQHVVVTWNAAKDGSFEPGLMHRWVETQVARTPEAIAVTNGAESLTYAQLNARANQLAHHLIALGVTPGSSVGLCLERSSLDMPVAVLATLKAGAAYVPLDPNYPTERLALMVEDTRAPVVLAHEGFVRALPPGTSARIVTMETVSLAARSTTSPNVKLSPEAVCYVVFTSGSTGRPKGIAMSHRGIGNMLAWQTRRAVRAQATTLQFASLNFDVSFQEIFGTWCIGGRLLLSSAELRRDPPALLSYLTQHRVERLFLPFVALQSLSEAARTSAELPPLNEVITAGEQLQVTPALVAFFERLPGCVLENQYGPSETHAASAWRASGPPSTWPALPPVGTPLTNVQTYVLDARGNPSPVGVPGEVFIGGEGLAHGYHNRPDLTAERFVPSPFSSTPGARLYRTGDKARWLADGQLEFLGRLDGQVKLRGFRVELGEVESALRALPDVQDVVVVLREDTPGFKRLVAYVVQPETGFSAEALRQALARRLPEYMVPSALVRMDALPLTPSGKVNRNGLPVPTEEAIPGTVYVAPVSAVEKLIADIWAPLLGVPRVGTQDHFFELGGHSLLATQVASRLRESLQMELPVRVLFEAPTLAELAARIEALRQEAHPLQAPPLVRTEAGDSAPQSFPQQRLWFIDALAPGGFAFNVPLFIRCKGPLDVAALERSLAALIDRHESLRTVFAEENGQPVQRVLPSVPFALAFERLEDVPPPQRDTVLRQRAEERMRHVFDLRTGPLLTATLLRLDAEDHALFLLMHHIITDGWSTDVMGRELGILYDAFTRSQTPRLPPLPIRYTDYARWQRATLQGEGLDAQLAWWKRQLNGAPHALELPTDRPRPPVQAQGGAAHMVRIPAAVDAAVRELCHQQGVTSFMALLAGFHALLSRYSGQDDVVIGSPISGRNHREVEGLIGFFVNALPLRVKVSGAESFQVLLARVRETCLGAYAHQEVPFEQLVDALQTPRDLSRTPVFQAVFALFKDFPGFPLRGLETAPVPFDPGLAKHDLTLFMRESATGLLTHWEYNTALFDAATVERMAGHYLRLLEQVTRNPERPLASLSLLTETERQQLLVDWNDTALDVPADLRVPTRITEQARLRPEALALAGDGQRLTFGELEARSNQLANLLRAQGVKPETVVALCVDRTPGYVWGALGILKSGGAYLPMDLTWPEAWWRHVLTDSGARIVVTLQAFASRFEGCGVRVLCLDAEPALETQPDTAPGVTLHAEAMAYVIYTSGSTGKPKGVAVTHGTLANLVAGLGTAASMGPGDRATLLTGLAFDATVFETWPALSHGASLHLPTDEVRAEPARLVRWLAAEGITLTTLPTPMAEAALEQPWPSGMPLRRVHVAGDVLHRRPGPSVPGQWRNCYGPTENTVIATSGVVKPEAPEGLLPPIGSPEPNVHVYVLDGTGQPVPVGLWGELFLGGAQVARGYLGQPALTAERFGPDPFSQEPGARLYRTGDVVRWLADGTLEFRGRADSQVKLRGFRIELGEVEAALLAQPSVKEAVAQVREDVPGQRRLVAYLVLREGAAFTVDALRASLRRSLAEHAVPSALVVLERLPLTANGKLDRKALPAPDVHRPELSEDYRVPEAGLEQTLAGLWAEVLRLERVGASDNFFDLGGNSLLLQSVHAKLEALVGRKVPLVTLFQYPTVRALAGHLSPPKDTPPAAAPAPAQDPGAQRRDNLRRMAQRRGRPGSS
>NC_017030.1|WP_014394902.1|2474077_2474854_+|SDR-family-oxidoreductase
MELGLANKVALVAGGSSGLGLAVAEELAKEGAHVAIGARDTDRLAQAEARLKSVARGGRVLATRVDVKDDAEVRRWVDDVVAKLGALHVVVTNSGGPPPGPASTFGVDAYRSAADAVLLPPISLALAALPHLKKAGWGRLLFITSETVHRPVARFALSGFARMGIVGFSAALVQELGDAGITVNVLAPGYMRTPPVERTAGNAGDVEAGLRAMGAHIPLKRVGLPEEFAAAAVFLASERASFITGTVQLVDGGASVIG
>NC_017030.1|WP_014394903.1|2474850_2475720_+|[LysW]-aminoadipate-kinase
MSAAPDAPSRRPVIVKIGGAAGVDLENVCSDVVELVRQGERVVVVNGGSEAGERLLGSLGLARPEATTANGNVVRLTYAPTLRALTMAWVGEVNKAVVLALLAKGVTALGLCGADGRVLTARRRPPLKLQDSDGRMRIDREHLAGEVSSVNAPLLGTLLDGGYVPVVCPPAVTEDGVLVNVDADHVASSIAAALGAKALVILSNVPGLLADPKDPASLVRSSDDVEGCMPLAGGRMRYKLEAVRRALQGGVPTAYVSASRVARPVFCALEEAGGTKFTLRDGGRADAGA
>NC_017030.1|WP_014394904.1|2475706_2476783_+|M20/M25/M40-family-metallo-hydrolase
MRAREPGVDLLRWMVEQYSPSHQEASFAGALVERLGARGWRAHTDAVGNAVARYGDGDTVIAFLGHIDTVPGEVPVRLEGQKLYGRGAVDAKGPLCAFIEAVELLDDAERAGKQFLLLGCVEEEVAITRGALHVRDQYAPDFVINGEPSGAHAVTIGYKGLLRLDLEHRASRRHTASRDYRAAAEHVIDAWNALKRLCDDWNRERPSLFEQNLPSLNAFHTGATETEEWATAAVSIRTGPSTDTDALLAALASVPTVTVRTVARKNAVSTNGNDALSRVFKQAIRERGVKPTLRLKTGTSDWNTVASAWAVPTVAYGPGDAALDHTPHEHIDLPEYEEGVAVLARVLALLPAKGTAGG
>NC_017030.1|WP_014394905.1|2476787_2478023_-|MFS-transporter
MATSLFSRSGSARALSHRDFTLLWLGTLVSNIGTWMESVALGVYVTQVTGQAAWTGGVAALTHLPSLVLAPLGGALADRFDRRTFMAVCICVQALLAALLTVLAATGNLSVPWVAVLSLLNGAFSTLVIPCATALTVAVVPPEDLHNALSLDSAQFNLGRIIGPVLAALVLTQVGIAGALFVNTLSFLAVLLALAGMRGAASPLPPKAEALWAGIMRGVRLAWTDPGIALALGSGALVGLLISPFVGLVPVFALKVLGGDATTTSMLLTAQGTGAVIAAFGSGAIVARMGRRAFLEAALLLVGLCSAAYWLSPSLPVALVTLFILGAVYLVAFTGLKTVCQARTPPELQARVSSLFLLLVNAGYILGVWGQGALSDRVGVRPITAGCALLFFGIVVGMRTLRARGLAALGT
>NC_017030.1|WP_014394906.1|2478122_2479049_+|RluA-family-pseudouridine-synthase
MTRHKVLVVPREIAGERLDRFLTKHVPGLTPERARAMLDAGRVRIRGKKAQATRKLWGGEELTLEVPEPRPSPHASVEGPELPVLYDDAALIIVAKPPGLVVEPEGRAASVVGLLAARCPPFDVEGLVQPGVVHRLDRETSGCLALARTDDAVAALLKAFQEKRVDKRYQTLVLGRPPDTGHLEGPYARDPKDPRRFTTRVPSARRAALTFTVRERFREGALLDIDLDTGRTHQIRVQLSEAGFPVLGDSLYGTEEACKHPAALAVGRQALHAWRLEVPSSATGQLVQVESPLPEDFLRGLTVLRGGA
>NC_017030.1|WP_014394907.1|2479102_2480608_+|putative-metal-binding-motif-containing-protein
MQSRMMSWGSLSLVAALLVSGCGSSTSPSGPVPDAGTQVDAGTDAGNSGDAGVADAGTVDSGVPEGAPCEKTQGVCAGAQRAWVDGAYEPVCTARSYGADYEASELRCDGLDNDCDGVTDPTTWADVAPMQWAPDTRWADSLPVEGGFLFVSSNGLSAIEFLRLDASLTLKGSAALPLSPAPIRVTRTQLVRTARGPALFSIVVYSEPSYFVRGSLTQLDELGTPGGEGVVLFEGPYTWANGHVAPSLDGERLAVTWTWELAGAREVQGMTVDPAGQVLAAPRVLHRSDSLDLSAAEVLGLGDGGFLVKANENKAGSFDDTRVWLQRYDRELLPVGDERILTVKYAAAPSLMLTAPSEEGGAGEPTLLYRDPHGLTPQFLQVRSLFNEGMAESLTSTSRGQTALFGATMTSRGLQLAWLSMPMVPNPGGDAAFGFEGRLWGRSATGVVTDWTPGAAAIPMNGTASWVRLHELAGHQLGALTMTATDTPRSYTLRSLRYCAP
>NC_017030.1|WP_014394908.1|2480704_2480992_-|hypothetical-protein
MADRILEQQHEHEREQERERLREQEQKDLEVESHRGARPLEGFAGGHTTWTGDQDDAAAARVHAGDAEASWEASERQARLEPPESDAEDGTGRRE
>NC_017030.1|WP_014394909.1|2481138_2482179_+|hypothetical-protein
MNPGVSIVADDTRSWGLETPGPGLLLHVPATGRWARRPAVHLEAARDYRIRLRGAGQTLLWARIDSYWDRAVLLRGTAPAPHVIPSLSAPEVRAVEAAPGTEAWWEAWAWRVARALVEAPLPVLHSGSWCLRPVRAIAAEKAERHPVSPMEWGFGQPPMPPHSVAALERYLFAWAEDWWDARTEHTPGVVLGLRALSSPEDGRVKSWRKRARDGTLPPVLLLYVDILAKWLVLDGHDRLHAALLEGVEPPLLGLWPFIDRPRPWNAVREDGALFSAEFQLRAGATPETVDRVNRMLLLNFTPNPRGTVSRAWPLPGGRETWSEEVSARRRRGRLPLLDDNAWDWLT
>NC_017030.1|WP_014394910.1|2482189_2482711_+|GNAT-family-N-acetyltransferase
MLLQHFERTTTDRLLLRAVRENDLDAVFALHSDPTTNRFSRHGYMETLDDARRVMGLWLEDWARDGVGYWLVERLEAPGVVVGLGGLRHKELEGQRVLNLAYRFTPETRGSGYATEVSRVALALAARHLPHVPLVAIIHPENAASIRVAERLGMRLDRHITEDDIQNRVYVIG
>NC_017030.1|WP_014394911.1|2482720_2486650_-|protein-kinase
MSAPPSSCLTDDILVQLLEDQLTDEALAQVHRHAAGCNECRSMLATLTPGIQRSSVEDPEPPDERETDRLPPPEPEPWTPPPSFDAFRLERPLGRGGMGIVYLAHDTSLDRRVAVKFMAAAQPDERFRDLFTTEARALARLQHANIVSVFSVGAVEGHPYIVSEYVVGETLAELPLPVPWRRVLSLGVGLARGLAAAHRQGVLHRDLKPSNALVTREGEVKLLDFGLAERFEVGAELASGSPLLVGTLPYLAPEVLTGGPASARSDLYALGLILHELCTGQVPRRASRKPEDTPPRAALGPEVDPDFAALIQRCLAVDPLERINSAEALSESLEQLERSIAPAPLAAGNPYRGLAPFAAEHRALFFGREGDIRAVLERLRTRPLVLVAGDSGTGKSSLCRAGVLPRVAAGDLGDGREPHVVTLWPGHRPLEALAAALAPVLGRREAELVTALTDTPAWLGQALRETHGRGRGLLLFVDQLEELLTLSDPGQAAHFARLLGELALPSPGVHVLLAVRGDFLTRLCALPGLGEEAERALYILRPLSPEGVREAIIGPARARGVAFESPELVQTLVDSTAHGVGSLPLLQFALAELWERRDAARGRITRSALEAMGGVAGALSRHADGVLARMSPAEHAAARRLLLQLVTAEGTRIERGAEDLADASDEVSRAALRVLVEGRLLHTRTVSGLPRWEIAHESLISSWGTLRDWLDDDIGHRVLRKRVEAASAEWDRLRRASEALWGQRQLDEVRVLEPATLGIREQAFLRASHRAVRRARWGRGLTALVLALAVLASYGGLRLQAYLEDSRFIAAELGTAKEALASGRTLAARALASREESLAMFDGRPPSSLGPETATDATGLRSAAEKRWTETLALRDKAEAAFTRASRSLERGLDRDRHHPDTRRLIAEVLSERVLLAEAFHQRHERDAWLQRLEQEVDSAKEGGASLRRFHEPAELVLESTPPGAHVSITRVLRSDGPFRREAVPATGSSRFVLPEGSYLLHVTQPGRVPLDVPVFLTHGAREALRLTLPTQVPEGYVYIPPGCFLLGSAEPEVVRRFTFSPPMHRYCLTGGYLVGRDEVTFGDWLTYLEDLPPDAPARKILEQPHFGDGGTITLRWRQGTGWVFTFHRTREEFRTAKEGEPLLYAERTRHASVDWKRLPLSGVSAQDLEGYFYWLHRTKRLPGARLCGQHEWEYAARGADGRRYPHGDQLQPDDANIDATYDRRPLAFGPDAVGTHPASVSPFGLRDMAGNAYELTRSVTPEFGSVVLRGGSWYYDSFVAASADLSPGDATARDVRIGVRVCASFDPR

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Crispr_ID: NC_017030_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_11

2506422-2506531

Orphan

Consensus_repeat	Method
TGAGGGAAACCCTCATCGGAGAGGATGCTCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_11

>merge|NC_017030|11|2506422-2506531|CRISPRCasFinder
TGAGGGAAACCCTCATCGGAGAGGATGCTCCGGCCGGAGTTGGCACTGCCGAGGCGAACGCCGTCGCCACGGGCGCGATGAGGGGAACCCTCATCGGAGAGGATGCTCCG

>NC_017030|11|9|2506422-2506531|CRISPRCasFinder
TGAGGGAAACCCTCATCGGAGAGGATGCTCCG	GCCGGAGTTGGCACTGCCGAGGCGAACGCCGTCGCCACGGGCGCGA
TGAGGGGAACCCTCATCGGAGAGGATGCTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014394923.1\|2504573_2505737_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394920.1\|2500983_2501403_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394928.1\|2512410_2513268_-\|general-secretion-pathway-protein-GspE	unknown	unknown	gnl\|CDD\|377474
NC_017030.1\|WP_014394926.1\|2510618_2511413_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_017030.1\|WP_043321181.1\|2510007_2510283_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394921.1\|2501605_2502106_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394918.1\|2496652_2497633_-\|ChaN-family-lipoprotein	unknown	unknown	gnl\|CDD\|350609
NC_017030.1\|WP_148282217.1\|2517012_2518635_+\|DUF1592-domain-containing-protein	unknown	unknown	gnl\|CDD\|377885
NC_017030.1\|WP_014394916.1\|2495563_2496100_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394917.1\|2496118_2496505_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394922.1\|2502195_2504223_-\|YgiQ-family-radical-SAM-protein	unknown	unknown	gnl\|CDD\|274847
NC_017030.1\|WP_014394931.1\|2515253_2516291_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103
NC_017030.1\|WP_014394929.1\|2513338_2513710_-\|Spx/MgsR-family-RNA-polymerase-binding-regulatory-protein	unknown	unknown	gnl\|CDD\|239334
NC_017030.1\|WP_014394932.1\|2516406_2516817_+\|SET-domain-containing-protein-lysine-N-methyltransferase	unknown	unknown	gnl\|CDD\|380938
NC_017030.1\|WP_148282518.1\|2488875_2494098_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_043321180.1\|2498014_2500975_+\|response-regulator	unknown	unknown	gnl\|CDD\|223715
NC_017030.1\|WP_148282519.1\|2506597_2509987_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|350195
NC_017030.1\|WP_043321179.1\|2494208_2495402_-\|lipoprotein	unknown	unknown	unknown
NC_017030.1\|WP_014394930.1\|2513749_2515108_+\|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl\|CDD\|275079
NC_017030.1\|WP_014394927.1\|2511497_2512397_+\|DUF459-domain-containing-protein	unknown	unknown	gnl\|CDD\|238867

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014394932.1\|2516406_2516817_+\|SET-domain-containing-protein-lysine-N-methyltransferase	gnl\|CDD\|380938	cd10540, SET_SpSet7-like, SET domain found in Schizossacharomyces pombe Set7 and similar proteins. Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).	7.75969e-33
NC_017030.1\|WP_014394928.1\|2512410_2513268_-\|general-secretion-pathway-protein-GspE	gnl\|CDD\|377474	pfam05157, T2SSE_N, Type II secretion system (T2SS), protein E, N-terminal domain. This domain is found at the N-terminus of members of the Type II secretion system protein E. Proteins in this subfamily are typically involved in Type 4 pilus biogenesis, though some are involved in other processes; for instance aggregation in Myxococcus xanthus. The structure of this domain is now known.	2.48484e-22
NC_017030.1\|WP_014394929.1\|2513338_2513710_-\|Spx/MgsR-family-RNA-polymerase-binding-regulatory-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	4.97968e-45
NC_017030.1\|WP_014394918.1\|2496652_2497633_-\|ChaN-family-lipoprotein	gnl\|CDD\|350609	cd14727, ChanN-like, ChaN is an iron-regulated, heme-binding protein. This family represents a domain found in ChaN, a heme-binding/iron-regulated lipoprotein from Campylobacter jejuni. ChaN, possibly involved in the uptake of heme-iron, contains a pair of cofacial heme groups situated between two ChaN monomers. A single tyrosine residue contacts the heme-bound iron atom while the heme-binding regions of each monomer also have contacts to the heme in the complementary monomer. ChaN presumably associates with an outer membrane-associated receptor, ChaR. Campylobacter jejuni is an important cause of food-borne illness, and is dependent on iron uptake from the host. ChaN like proteins are related to the Tiki/TraB like family of proteases. Proteins containing this domain also include protein reticulata-related from Arabidopsis which may play a role in leaf development.	5.66914e-65
NC_017030.1\|WP_148282217.1\|2517012_2518635_+\|DUF1592-domain-containing-protein	gnl\|CDD\|377885	pfam07627, PSCyt3, Protein of unknown function (DUF1588). A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match pfam07626 and pfam07624.	2.3702e-48
NC_017030.1\|WP_014394930.1\|2513749_2515108_+\|right-handed-parallel-beta-helix-repeat-containing-protein	gnl\|CDD\|275079	TIGR04247, nitrous_oxide_maturation_protein_NosD, nitrous oxide reductase family maturation protein NosD. Members of this family include NosD, a repetitive periplasmic protein required for the maturation of the copper-containing enzyme nitrous-oxide reductase. NosD appears to be part of a complex with NosF (an ABC transporter family ATP-binding protein) and NosY (a six-helix transmembrane protein in the ABC-2 permease family). However, NosDFY-like complexes appear to occur also in species whose copper requiring enzymes are something other than nitrous-oxide reductase.	0.000651596
NC_017030.1\|WP_014394931.1\|2515253_2516291_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	1.06024e-32
NC_017030.1\|WP_014394926.1\|2510618_2511413_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.4291e-10
NC_017030.1\|WP_148282519.1\|2506597_2509987_+\|AAA-family-ATPase	gnl\|CDD\|350195	cd18808, SF1_C_Upf1, C-terminal helicase domain of Upf1-like family helicases. The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.	3.37528e-27
NC_017030.1\|WP_043321180.1\|2498014_2500975_+\|response-regulator	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.33451e-52
NC_017030.1\|WP_014394922.1\|2502195_2504223_-\|YgiQ-family-radical-SAM-protein	gnl\|CDD\|274847	TIGR03904, putative_radical_SAM_protein_YgiQ, uncharacterized radical SAM protein YgiQ. Members of this family are fairly widespread uncharacterized radical SAM family proteins, many of which are designated YgiQ. [Unknown function, Enzymes of unknown specificity].	0
NC_017030.1\|WP_014394927.1\|2511497_2512397_+\|DUF459-domain-containing-protein	gnl\|CDD\|238867	cd01829, SGNH_hydrolase_peri2, SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	7.86673e-66

>NC_017030.1|WP_014394923.1|2504573_2505737_+|hypothetical-protein
MSLRHPLSLFASLLLLGGCGTETLEEGAALGEARSAVNTGNGEHTGIDLAVTELGVTCEGDVLTVTGTIKNAAPTGIDPSIAGIYAGNPAEGGTLLDTINVPWLVGQETYPFSKVVTVPEGTQQLYVVADNFGFFPEDDETNNTAMVTLSPGGGCLVNQPPVALCKNVTVSASATCSAAASIDNGSYDPDGFPQSLSITASPAGQYPVGTTPVTLTVSDGMDSASCSATVTVVDDAAPVAGASKNLVLARTLGADYKTVTLADCAQPATDTCGGTLNLQQSASIIRVESDESEDALFSLALFKCKDIVLSADRKSAQLRAESSLLGNGRVYTMVYSVADASGNATIGTCKVKVPSPLGILSVGLGPNYCQGEGCPAGTGNGLLCPLL
>NC_017030.1|WP_014394922.1|2502195_2504223_-|YgiQ-family-radical-SAM-protein
MASITPRYAHPFLPVTRADMQARGWEQCDIIIVSGDAYVDHPAFGPVLIARFLEGRGFKVGLIPQPDWHSAEPFKALGAPRLFFGVAAGNLDSMLNRLTAQKKNRSEDQYSPGGRTNCRPDRASIVYAQRCREAFPDVPIVLGGIEASLRRIAHFDYWSEKVRRSILFDAKADLLVFGMGERPIWEIADRLHRGERIEDLKDIRGTAHLINDAAMKALEADPAKRAADHGKVVVLPSYEDVVADTRAFAVMSRDFQLETNPGNARAIAQRHGNRAIYMNPPARPLEDGAGQKPGDTATVAMDELYDLKFNRVPHPMYKEPIPAYETVKHSVVLMRGCFGGCTFCSITEHEGRVIQSRSAASVLREVRELRRMGDFRGTITDLGGPTANMYKLKCKSEDIESRCRKLSCVHPGVCENLQTDHGPLISLMKQVREEPGIKHVFIASGVRYDLAERSPEYVKELAAHHVGGQLSVAPEHVSPRVLEKMKKPGIESFERFQHMFACASEDAGKEQYDIAYFISGHPGSTLEDMVMLAQWLKEKGKRPRQVQDFIPTPMSVATAMYYTGLDPLKMEPVYTAKGLREKRLQKALLLYWNPEHWPLAREALKLAGREDLIGRGPKALVPPESAAEAARLRRASEGSNAEEGLPTNAWPRPAQPRPSGPRGGGRTPRPGPRGR
>NC_017030.1|WP_014394921.1|2501605_2502106_-|hypothetical-protein
MPRTSQEQSQERHAFLLDLFRNQPDLSRQDALESFKDRFGATINLRTFNELREQAKKELASQPAAPVAAPKEEQDVDVQDERAEVTAEDAGTLLKAAAAPELHAGAAPAKKPKAKGPGSRNVFVDASAEQLQFLERVVQQLQEAGAANVRIDHATDRWMVLVVDSK
>NC_017030.1|WP_014394920.1|2500983_2501403_-|hypothetical-protein
MTRSIPALALVVGGLLFGCGGMPEEGDSQVPSEGNVSQSAVTYIYGNGVTVVYNSASDSFTVHDTLADGHSAVARIYNSNTGSTTYCWNSNGAGTSAVCNRNYPNNPLLRISACTGEAGPGTIVACSSAVPVDAFAPTK
>NC_017030.1|WP_043321180.1|2498014_2500975_+|response-regulator
MGRLILERDWSGTPLGPIASWPPTLRTLVSMCLTTRFPMFIYWGPERVQLYNDAGIPIMGAKHPDHALGPLRDVFPELWPQLGSMFDELERTKQANWAESQSLPIQRGGFAEEAYFTWSYTPVLDDDGTVVGFYTPALETTGQVLGQRRLRTLHLLTQRAGGAGSVEEACRAGLDALAENPADLPFTWLYVTDAGGTRASLVGSTGMGARSSAVPAHVDLRTPEEGGPSGGLLSPVASTRQAWRVDDVNGWLGAPLAPEATEPPRPALVLPLPHAEGDRDLGFLVVGLSPFLNPSGEYRGFLELVAGALATAASSARARQEAVERMERLAALDRAKTAFFSNVSHEFRTPLTLMLGPVGDALSDPAEPLAPRLAERLSLVQRNATRLLKLVNTLLDFTRAEAGRVRAAFQPTDLSAFTAELVSQFESIAKRAQLTLTLDLPPLAEPVWVDREMWEKIVFNLLSNAMKFTFEGGVHVRLRAEEGRARLTVRDTGSGIPEAELPHIFERFHRVENARSRSHEGSGIGLSLVQELTKLHGGTVGVTSTLGQGTTFCVAVPLGNGHLPREQLVPEGGIPTHSVARSASAYVEEIRGWLAPTGLEDGARVLEGVRATPLLPPMSARVLVVDDNADLRTYITGLLDASVTVETAEDGYAALQAIRARPPDLVLSDVMMPRLGGFGLLRELRADPRLRAIPFVLLSARAGEEASVEGLEAGADDYLVKPFSARELAARVRTQLEMARVRREVAELSAREAVLQDAVRARDEFLSVVSHELKTPLAGFRLQLDLIERGLGPDVHARLGERLLFTRRQVHRLATVVETLLDMSQLSSGPVRLNVEDMDLAALVTEEVAQAREELCREGCELTLRIAGPVRGRFDKARLEQVVQGLLSNALKYGPGKPVEVHVEQVGPHARLTVVDHGMGVRPEDRERIWKRFERAVSVRNFGGLGLGLWIARQVVDAHGGSVSVSETPGGGATFTVSLPLDGPRV
>NC_017030.1|WP_014394918.1|2496652_2497633_-|ChaN-family-lipoprotein
MKRTTTALVLALSLGCASKQQPSPPPAREWATTLHRDHPLVGRIWDVAGGRFVDESALRAAVVPARFVLLGERHDHPDHHRLQAELVRARTASGQRPALAFEMLDVTQQPALDAALKAHPEDAEALAKAVDWANSGWPAFSLYEPVFTAGLQARLPIVAANLPRAQVRELVMKGPEALPSDLRSRLGLEAPVPEAEAKAVREELDRSHCGQLPQEMLEPMALAQRARDAMMADRLLETVPADGAVLITGNGHVRKDRGVPAHLERRVKDVTVLSVALLEVSPEALNPQDYAAVVGATALPYDYVWFTPAMPEDDPCKALRERNKKQ
>NC_017030.1|WP_014394917.1|2496118_2496505_-|hypothetical-protein
MFKKKAAIALGLTMLAGSSTAWAGAQGTNPVVINTTNKTLEGSLGSARNSSDPIQSLDIGFYGGSSYLYGFIFAFDASGTMAACSTFDPNMIEVLKAAASDSYIKVYHDGAGTCTDIEMRKASYLEPK
>NC_017030.1|WP_014394916.1|2495563_2496100_-|hypothetical-protein
MTMASRGLYLAALVASAGAGFGMARWTGPTAVATDAELPRRLEGVERELRALRQGLEGPSRPAPVAVAGLDARALQEDLRRMVREEFQTVTAEARAESPPDRPEPAPPIPSGNLEAYAKARRVLEDGIASRHWGDQERGELRALREKLTQPQLRELLTKLAVAINQQQLRITTHGPPF
>NC_017030.1|WP_043321179.1|2494208_2495402_-|lipoprotein
MTMTTRSLGFRAWRWSAVLSLLALTGCAVEPQPQEQAPDQEEQAKVLEQQAHELTPPAGCTEITMGALSNGVQLTPVMYGGQPTYQGTFNGLGDPALKDTAFVRLDVNTATGVHDLAAGGANTFTCEQCVYGYQDAGTAGQKLFVADTGALLLALKVSPQQSVGVLFNVTLRESVNAAPLSAPYKGSAVVPGGECKWIRYATWNTVRPMGCDPREGSWTANVPGHTCVADNYFADDGTLEKSQGTGTQGAACTRTPAADANHPATTDCAEGFACSDLFTDDRQCLKTCDPMAAVPGCPTGTICGVYGTCIEQAVLEPLGFDFDPALIGETCTKTYAEFCGTEGARGACVSLNGQTKCQPYTRARSECGPGEELGFINYPLSGGGYDRTTGWCYHDGL
>NC_017030.1|WP_148282518.1|2488875_2494098_-|hypothetical-protein
MLCPACTEPRALDSGPLCPECGAALVPAAGRHLDDFVLARMRRRIEHWRFDGVLDAATADRLEASLAAPPDGVASILEVPAPEAVEVPVPVEPALDSAARVEAWADEVAHSLRRAGGWRPGWLASIASSLDETARAEREQAARRVSSLDVGASSRAEDLGDGSARAKREQQAARRRVVVAPDEGESSSEEDLGSALGSGQALFGRGHLDSLGGSGLEAVIALDEGDNPPRFNEYIWWFLGAVLVLGGSLMGVREAWRALGGVPRQLIVTGALLGYHAAFIGLGTFLARRSRSAGRVLAGIGLGLLPVVFIALSALVALTPMVGVPTALGVAAVALLPLRAAGRLWPGASATTFAVALFPSLLAGLPLMGWDDAPWLRALCAFAGVVALGASLWRARAADAGEGAPEASRSRAAAAGAVEASPWRAGAASFAGVGAALYGALWLVVFCVASGPSGFDALEPGAPLFAGLVLWAVALGAVVAVGASSDAVRAAHPRAAPVFETLAHAVVASGALAGALGAFSVFPGEDAWVDTASICAPVLAALVFFLLEFRRRALVHPAVMASLLAGALVARVQAPDDPAWWCFGVAAVASGLMLLARVTFSGVLRPRMLAWSVVVSLATMPAFSVLAWTQGTNAPWPQAYTGAVIAFAAHFAGRWKWRGLHYLGGVALLFGALSAVDGTPWLASSAAGLGVFALAAVLYGLGGLAQSAWLERQGLRDAFHPLEDLSLAIAALGVARALGVAPALPDVLAGVDEPFSTLLACAPTAVATAVLLLRVRRDGSRLVGFLAAMGFALTVSQGLGTVSDFTSARAALVAAGLAFGFALFAMLRGPGLDTVKGRRLLDVFPMPFGARGRPLFTDGFAGAALVQAVLAVITLINWVALPDSAERPVALLAGGLLSAGALLAFVSRGFVAFQMRGSVVTLALSGGFIALTGAVNRAGRPLPPDVSAWRVPLIGIALWVLALGLRRVGPWVAQRLERPKHGSLYHLVPHLGVAVLAVLLLRSAIAVGLPGPSRALGLVPPLLVLGPALLMVLLAASFRSRLLAHWGLVLGLPGAALWAAQQSLLGSPLVALRPPDGQWIRATAEHLISPSLGWLHPDAWMPPDSTHFLLWQQAFAGIAAAGLVYAVFAVAVARVDAGRAFFRRLLSLGTDNRPGPFLDALSRETLTAVVLVAVAAFFQPGVLAADLVLATGAVLFVGGARGRGRGVVGLGLLLLVHALAHLMPHLEPWPGPTLALLGLGVVVVAPWLAKRRGHDEGRTRLRAHLAVLPYFIAATVYALAVEGHSSSTMAVPVLVMEMISGLTGEWLMSFAFPLTLGLLSAALLVAAFQWRGALAGFIAGLGTMVAGGAVVATGLAFLAQARAPWDPTYLPLFTRSGAQLALAAAGSALALHVARRMTSRRRNDVAGGMGWGRDLWLVASAALLAAVAVGGQASEDVLPVALAAIGLAVGVSLHAAWREHTGRHVYFVQLAVVGVYALVRGLYAQGLRPEHDALFALSLGFVLVGVTVLARRAGVRPVERATRRFAALLPIAVALILPGDATGDAALLAGGSGLLYAALGAVERSRMFGAFAAAACNLALLIAALAFGLEGLEVYLAPLGLLLLMMGQLFTSSLPHAARNAVRILGGLLLYVPAAAKLTASLGESEDGTYAIVFGAVCLLGVAVGMALRIRAYLALGTLFLLLDVVANLLDAGLRDHRIGFLVMTLTGLTIVAGRVMATLKRQEWDLLLRRVRVQLRGWD
>NC_017030.1|WP_148282519.1|2506597_2509987_+|AAA-family-ATPase
MVTPGVRPFASDAASGGSNGRAPKPPAPNLVRVDDVADARPPEEAPARDVSASGDVTPAEREAMQAAVSSGRRREQWVAPTYLPEDLRDALVAERSQYRAQRIQEAREVGLAGPGVLGLVPVPAADPDWSGGSLLGFLGEELVFAGNIVHLDFESGRVFASSDSGEDLDRRVLSCERWCYRPYDFAEALCAAAAAYEDRVSDLTNALARAKGELLPSTPSPRDAELIPVDRLWRQPWGSIWGPPGTGKTTAVADLIARALRAYPHERILAVAPTNRAADELVMRVSALLERDPIPLRPLARSIFRGGTGASESLHKLPTVALEENKTSKLLNTIQQRERELTLERSRGGPAPELARMQAELRSLRGRVKDPTLKEAEKGESPLMVLTVHRALRLVSELEGEETFQRLVVDEAGMVTRAATALLAPLARQVTLAGDPKQIGPVSRAAEGAGKGTQTWLRASALSHLEDAVKDAERPDVLLLRTQHRMHPDIAKVVSHFCYGGALEDGDLVKDRAQKPAPVPAFPSRAMWLVLDGLSRDTRRLTHGRGETGSGYQRELSAELAVTLARQAVRLGLTVLCVTPYRAQAALLRKLGNAAGLRHDMFSASTIHRQQGTQYDVVMVDTVAGGRPFPPHTLVPILNVAASRAKEYLLVLASRAEARASPVPARFLSLLPRVRVHAGTPPKLELLATQPRPPPPPPPPLVPVGLGGEIEGGKDTGPLFTQEQVSLFERRFDDGHHLVRGVAGSGKTYVLAHWAARYLLENPRARVLVSFYNRSLAPLVDKLLMEALTVRAGPDQVRPLRAQVTVKHVGALRRLEPHAFDAVFVDEAQDMDAKGLAALHALVRPIVGEDGRESRCFQLFMDDSQNVYGQVPIDSLKEQLPEGLSFRGRTRVLKETFRATRDILDVAFNVVLDPLRQHRVTDPGMREYMKAGELARERLLWLPEETLEGLYRVQSTERGGVLPQVKDFASSTSEARWVAKEIARLVREEGVHPGDILVVAPVMPASFTDALRKAGVPAEAYGGKGGRDVTDFRVSGVDHVRATTVFSCKGHECPVVFFAGLEALDSIEAWMAGARQRNERENERIRRAMFYVGATRAMKRQYLTGVRGGRFLRVAASYVETLSGHRPAP
>NC_017030.1|WP_043321181.1|2510007_2510283_-|hypothetical-protein
MVDSTELVGETLERALSVFERLQDQDTAAVAQWLDGAMSRCFARMGGQLPDTRAAAPDLQQTFDLLRARFREVYAQPAFGKSAGVPGGWRM
>NC_017030.1|WP_014394926.1|2510618_2511413_+|alpha/beta-hydrolase
MRRTVELTDMAGNDEGPRVLLLPGLGARGSGFRELALRLTDVARPVMVEYPEGEHAACGARALAEQVLRVTGKVDAVVASSFGGMVAAHLAAGGATRGVAFLGAFTRTEHVGPRGRLIAMMGPIAVLGRPGRVAASLAAWRPVASHQVADVVPTTMLERLTTLRRAFSIHAEPPPPDLRPLNVSCLCIQGDRDVLVPPSSLERLAASLPEGTPRHLLRGAGHVPYFSHPEECARLLTPWLQALAPAGLAVLTARGLGADVGSAA
>NC_017030.1|WP_014394927.1|2511497_2512397_+|DUF459-domain-containing-protein
MSTRPLRALLFLAFLSTSAQAAADSAPGLNASPVLPTAPAQAAAPAPAPRRTVLLLGDSLIATGFGEYLQNQLSAHPRIRCERRAKSSTGLARPDFFDWLEVGQQEVQQHQPDVVVVILGGNDGQALHTRQGRATVAWGKPDWQGEYRQRLSDFVTAISAPGRKIVWLELPATGRQRFEQKLAVIRDLQREVIAARGDAVHLDTRPYFTDARGKALKQARVEGFRKPMRLRMTDGVHFTVAGGRYFANKVYPEVLGVLGLEHAEPEEQHTTRPAGAPVKPAMQALAPVAPAAPEAPTKP
>NC_017030.1|WP_014394928.1|2512410_2513268_-|general-secretion-pathway-protein-GspE
MEIGTRRPLGEILLELGVVDKGQLRLGLVHHHEVHVPLGRALVSEGVCTEADVLRGLAIQFDVEAVDLDRHPLDRALTKLVPARIARQYGVVPLRLETREDKEVLHLAVPAPLSLDAVDDVRAVSGKARVEPHLASDGALSRALSALYGIRETAGAAQEPPRPAVPSPPLMLYGWPPVTAVLISRTLARNSIPSRVATPLDVLHTRDNDVVLAPLQAMEGLLAGEVHIEGALIVHGTSDDEGFERARKLGARGFLANPRDEELLLRAVRRLRPDAGSESSWPRHS
>NC_017030.1|WP_014394929.1|2513338_2513710_-|Spx/MgsR-family-RNA-polymerase-binding-regulatory-protein
MSDDILVLAYSGCDTCKKALKWLEARGVSYTTRAIVDQPPTVAELRQWIPQSGVSVRKWLNTSGQSYRALGKEKIDAASDTELLEWLAKDGKLVKRPVLVTKKAVTVGFKPEAYEALFPLHGS
>NC_017030.1|WP_014394930.1|2513749_2515108_+|right-handed-parallel-beta-helix-repeat-containing-protein
MNRPATLHTVLSVLCLLGGGVGCSGEVEFAGEVPSGIVPDSGTPDRDDAGAPDRDAGMIDAGTADAGTSDAGTADAGTPDAGTADGGVVIPADGGTQVTGTLPARLTLAGSPYRVVGNAQYVVTIPKGQTTTVEPGVVIDFKGNPAVTEADVRDGAQDVMNHQNGRVELRVYGRILVQGTASAPVTFTSTNPYGWWGMNFFGDQSKGDGDPVFRHMVFEKVRKNDYNGDRDRTRGALWAYYPGSVTIEHSLFRDNESSGKCGALDLMFTDGSVVTDTVFENNRTRDIDRFATGDGATSGGGAMCVTHGRNSIVRGNTFRNNTLSAFRGSRANALQPRTYEVWPNGTNHYDLGGGGALHYFQPDHDLIENNVFENNAAVRGPGAALYLEDVPNAGVTLRGNTFTGNQAGAGGVIVCNRGSGDATELVLGAGNTFSGNTVNGAAAPQVTGDCAR
>NC_017030.1|WP_014394931.1|2515253_2516291_+|flippase-like-domain-containing-protein
MEGTRAEPIPTLEEPLEVPAKRRRGWWIPGVLVLVALLAFILSRHNEEKQFLELLRQARPAWLLVAAACQVGTYLCVAGIWWMVLHRARIKTSLWSLARLSLMKLAFDQVIPTGGVGGSLLVGRGLRRQGANPGVAAGAVLLTVLCFYVAQALGVGVSLYFLWRRSELNDWIQWLVTGFGVVALIIPLGILWATRHREWKPGRFARRIPSLGTLLKAIAEVPPGMLLNPGLLARGVLLQLGVYVLDAATLGAMLQALGQEVPLSTVFVSFMVASMAETVSIIPGGVGTYEAASVGMLNLFGVPVEAALAGTLLLRGFTLWLPLLPGLYLLRHTFRRRPVAGGQAG
>NC_017030.1|WP_014394932.1|2516406_2516817_+|SET-domain-containing-protein-lysine-N-methyltransferase
MNLGPALFLHPGVKVRPCEWGMGVFTDTFIAAGELIEECHYLKVPQRLCRGEPLDDYVFEISWHRHEQHRPGNWVALVMGYGMIYNHASDPNAEYGRAEDRDVFRYHALRDIHPGEQIFISYGDNWWKARGEEVPP
>NC_017030.1|WP_148282217.1|2517012_2518635_+|DUF1592-domain-containing-protein
MPLRRFYLSSALVLSASACTGNIGGQDAELESAAAPARVRRLTRDEYNKSASAVLGTEVDIAQGFAAEDTILGFSTHERLQVTSLLADQLDTAAVTLAEQGKSQLSDLYACPKGKTQDECARSFIQRVGERAFRRPVTAEEETDLLALFNEGKKGGTMATGAELVLQALFSSSSFLYRTELGPEGARKGQVVELTAYELASELSFMVTGGPPDATLLASAKAGTLSSPDEREAQARRLLKTEAAQVKLRQFFVEWLGLGGLAKVNKNNLVYPDYSVDFRDSMVRERDAFLDFIVKEHSGSVAELLGANYSFVDETLANFYGELERTNVDDTTGLGRVTLPPERLGILTQAGVMSTYAHFDSSSPIKRGKFVLTRLLCRTVPAPPANVSTIPPALSEDATTRERFAAHTDNPACASCHKVIDPMGFGMEDFDGLGQHRTEENGKRVDASGAVIARDGTTNLGNFTGGAQLARYLTTSEELANCVPLQFVRYAMGRDEHASDAELLAAMRTGPYRTGGLKITEALVSLVRSSSFTQRRLPTR

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Crispr_ID: NC_017030_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_12

2531914-2531994

Orphan

Consensus_repeat	Method
AGGGCGCCCATGAGGCCACCGCCACCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_12

>merge|NC_017030|12|2531914-2531994|CRISPRCasFinder
AGGGCGCCCATGAGGCCACCGCCACCGCCACCCGCGCCGCCGAGCATGCCACCCAGGGCGCCCATGAGGCCGCCGCCACCG

>NC_017030|12|10|2531914-2531994|CRISPRCasFinder
AGGGCGCCCATGAGGCCACCGCCACCG	CCACCCGCGCCGCCGAGCATGCCACCC
AGGGCGCCCATGAGGCCGCCGCCACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014394940.1\|2528725_2529871_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173849
NC_017030.1\|WP_014394932.1\|2516406_2516817_+\|SET-domain-containing-protein-lysine-N-methyltransferase	unknown	unknown	gnl\|CDD\|380938
NC_017030.1\|WP_014394941.1\|2529873_2531526_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223065
NC_017030.1\|WP_014394950.1\|2538696_2539395_-\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|238449
NC_017030.1\|WP_014394952.1\|2541143_2542496_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_017030.1\|WP_014394946.1\|2535027_2535237_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394935.1\|2520118_2521423_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394938.1\|2524840_2525689_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014394947.1\|2535289_2536507_-\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NC_017030.1\|WP_148282217.1\|2517012_2518635_+\|DUF1592-domain-containing-protein	unknown	unknown	gnl\|CDD\|377885
NC_017030.1\|WP_014394943.1\|2532323_2532812_-\|8-oxo-dGTP-diphosphatase	unknown	unknown	gnl\|CDD\|239519
NC_017030.1\|WP_014394945.1\|2534564_2534975_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_148282520.1\|2521755_2522385_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237865
NC_017030.1\|WP_014394939.1\|2525786_2528675_+\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NC_017030.1\|WP_014394937.1\|2522375_2524511_-\|ATP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|226482
NC_017030.1\|WP_014394934.1\|2518647_2520021_+\|DUF1552-domain-containing-protein	unknown	unknown	gnl\|CDD\|377875
NC_017030.1\|WP_014394948.1\|2536538_2537711_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369540
NC_017030.1\|WP_014394949.1\|2537808_2538477_-\|DUF4476-domain-containing-protein	unknown	unknown	gnl\|CDD\|379689
NC_017030.1\|WP_014394944.1\|2532865_2534398_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274150
NC_017030.1\|WP_014394951.1\|2539391_2540963_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014394940.1\|2528725_2529871_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	1.44818e-132
NC_017030.1\|WP_014394932.1\|2516406_2516817_+\|SET-domain-containing-protein-lysine-N-methyltransferase	gnl\|CDD\|380938	cd10540, SET_SpSet7-like, SET domain found in Schizossacharomyces pombe Set7 and similar proteins. Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).	7.75969e-33
NC_017030.1\|WP_014394941.1\|2529873_2531526_-\|hypothetical-protein	gnl\|CDD\|223065	PHA03378, PHA03378, EBNA-3B; Provisional.	0.00233329
NC_017030.1\|WP_014394950.1\|2538696_2539395_-\|carbonic-anhydrase	gnl\|CDD\|238449	cd00884, beta_CA_cladeB, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	5.07742e-84
NC_017030.1\|WP_014394952.1\|2541143_2542496_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.31084e-153
NC_017030.1\|WP_014394948.1\|2536538_2537711_-\|hypothetical-protein	gnl\|CDD\|369540	pfam07819, PGAP1, PGAP1-like protein. The sequences found in this family are similar to PGAP1. This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body.	3.45294e-05
NC_017030.1\|WP_014394944.1\|2532865_2534398_-\|hypothetical-protein	gnl\|CDD\|274150	TIGR02474, pectate_lyase, pectate lyase, PelA/Pel-15E family. Members of this family are isozymes of pectate lyase (EC 4.2.2.2), also called polygalacturonic transeliminase and alpha-1,4-D-endopolygalacturonic acid lyase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	1.33737e-05
NC_017030.1\|WP_148282520.1\|2521755_2522385_+\|hypothetical-protein	gnl\|CDD\|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	0.00690882
NC_017030.1\|WP_148282217.1\|2517012_2518635_+\|DUF1592-domain-containing-protein	gnl\|CDD\|377885	pfam07627, PSCyt3, Protein of unknown function (DUF1588). A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match pfam07626 and pfam07624.	2.3702e-48
NC_017030.1\|WP_014394943.1\|2532323_2532812_-\|8-oxo-dGTP-diphosphatase	gnl\|CDD\|239519	cd03427, MTH1, MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the incorporation of such oxygen radicals during replication. This is an important step in the repair mechanism in genomic and mitochondrial DNA. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for activity, and contain the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as a metal binding and catalytic site. MTH1 is predominantly localized in the cytoplasm and mitochondria. Structurally, this enzyme adopts a similar fold to MutT despite low sequence similarity outside the conserved nudix motif. The most distinctive structural difference between MutT and MTH1 is the presence of a beta-hairpin, which is absent in MutT. This results in a much deeper and narrower substrate binding pocket. Mechanistically, MTH1 contains dual specificity for nucleotides that contain 2-OH-adenine bases and those that contain 8-oxo-guanine bases.	6.8347e-48
NC_017030.1\|WP_014394947.1\|2535289_2536507_-\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	0
NC_017030.1\|WP_014394939.1\|2525786_2528675_+\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	4.37797e-10
NC_017030.1\|WP_014394937.1\|2522375_2524511_-\|ATP-binding-domain-containing-protein	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	4.00717e-29
NC_017030.1\|WP_014394934.1\|2518647_2520021_+\|DUF1552-domain-containing-protein	gnl\|CDD\|377875	pfam07586, HXXSHH, Protein of unknown function (DUF1552). A family of proteins identified in Rhodopirellula baltica.	2.40662e-88
NC_017030.1\|WP_014394949.1\|2537808_2538477_-\|DUF4476-domain-containing-protein	gnl\|CDD\|379689	pfam14771, DUF4476, Domain of unknown function (DUF4476).	3.11165e-05
NC_017030.1\|WP_014394951.1\|2539391_2540963_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	5.16216e-91

>NC_017030.1|WP_014394941.1|2529873_2531526_-|hypothetical-protein
MTFLSRMQPSPAPIAPRRLPEAPSQGPATRPAQRPAVGRPGDGFEVRGGRAGPAGAPGGIAAGGVRGSPGQGPVAGGAGSDGPGSLGLEGGVAGQVQPEGLAAGGVGGTAQPQGAMDMLLQSARDNVPGFTWLESKVDGALKVLGAGTDVTGSQVDLESMKPGDKFSTSGGFDGGYKIGRLQTRAQIEVSCEEGMRTNPTTGAREPGPNYRLSIDSEVLGGVGFENSKLDAKLLAGGGGKVEFKFETPAEVARANRIMDRMKTGMQANIAGAADMPPKEDIEWLQSKMAAVELRGTGAAQFAADIPVPGGPLVNNLDVGGKARSDRTVRIEFPEGKPPEVVIKDAVQVEVGGGPNRNLEVDKSIVGQDRMKLPIKAGVKVGTSLRGSGKLEVETRIPLPAGSKTDEILKDPKAALGPALKDMAANSRSKVTLTVEGAGLVQGNGKGTSYEVSIEGNPGTLVKNGAFGKLLEGDVPGAFEKAGKDATVEYKETSYTQRGVSMAPGFKVGPVKVGWELEVARRTVDGTPTVWKGNGADAARWLEGPQGQKAA
>NC_017030.1|WP_014394940.1|2528725_2529871_+|acyl-CoA-dehydrogenase-family-protein
MDERFTPEHDAFRRTVRQFVEKELAPHALEWDQAGEFPRDVFRRCGELGFFGISHDPAYGGSGLDYWYVAAFAEELARARNGGVAMSLLVQGQMATPVINELGTDEQKREFLAPALTGERIAALAMSEPDAGSDLARLRTTARKDGDDYVIQGAKTWISNGARADFLVLAVRTGGEGAPGISLVTLPTDVKGFSVSKKLQKVGHRSSDMAILYFEDCRIPARYVLGRENDGFFHIMNSFHAERLVTALYTVAVMDDLLREAIRYGRERQAFGKRLLDFQVWRHTFVDHATRVEAARQLTYQAVQLFNRKRKQKPVKEIAMAKLLTTELAQRVAYDCQQFYGGMGYVEESHVARAWRDVRMLTIGGGTSEVMKEIIAGTMAL
>NC_017030.1|WP_014394939.1|2525786_2528675_+|carboxypeptidase-regulatory-like-domain-containing-protein
MSSRKVFVVVAGLALLLAGVFVWMRASAPAAAVRAEAVATPERPASGPTRAPVRNGGGATAPVEQPMQDADGALRVETVTASGPLAGAEVTLYLRGPASPGSRLPSWRVAGQGRTDAAGALVLPARPGPYLVTAHAEGLALARAEVTRPHGEALSKVRLLLESGVSLTGLTVERVGGAPVPMTELTLTPHTGFEDALPVFLQTGASVPDEARHEALSDARGAFGFHGLARGEYQLEARAPGHAPRRIARVHVPGTDVRVEMDGSAFIEGFVTRADGTPAPGARVSAWGEDGAVEVEAGDTGSFSLDVPPGSFQVTARHGAETGTVVERPGSTVKGETGAAEGPIVVGPGMTVKDVRIRLGGAASLAGVVRRKDSGEAIAGATVGVRAHGDRADLLQARSEADGRFEVGGLAPGAYDVQVRAPGFQPLTRTGLGVLAGQRFELVLELAAPGRIEGTVVDGSEAPLPGVSVVAQLRWRPLPDALPSVTDAQGRFTLEDVPEGTVYVAARRADSEDEVRQPVRVEAGKTATARLTLVGEGVLEGTVRKEDGARPSGAVTVTAHRVGAAASESVDVPAKPDGTWSMRVGAGRYQLSAWLSALRFQNGDQQQVVELEAGGRRHVDLVVGEPRKPLRVTVLEPNGAPSVHATVMATEAGHTDIQAEEMTDAAGQAVLALDGLGSDAWRVWSTNGGRQGEAASVSASQKELTLQLKPAAQLRGTVRSAGGREVRGFALTVTAARGEDDFLSSVERQFSGDSFQVDDVFPTRVTVTATLPDGRAGKVDVTLASGAEARVEVVVDAGGGVSGRLVDARTNEPLAGAYVDADGIASPTTGADGRFELKDLAPGAHRLTAWSRGRELVDRRVTLAAGKTQALGDWRLGLQRVEPGRLGLSFGMTGRDVVISGIAEGADVAGLQVGDVVRSIDGAVVLDTGEARRRELGAPGSPAVLALQRSGQALSFTFIRAR
>NC_017030.1|WP_014394938.1|2524840_2525689_+|hypothetical-protein
MTSMNAPFRWTLSLAAALGIATSAAAQEPEPQTETETSTSPATTTMSSEEMQKSGGHHPEGRVGPQFAVSGNVGFGLGYVYTNGQAPGGGLEDLKITQSAKISFPIIAELGFRVTPRFYLGVWGSWEPVLTKTNDLSCPEGFDCSTYQWRVGPEVRYHIRPGSSFDPWIGLGVGLEILKSHVEGDTQLQVAPNVFVPTHVDTHVTDRGPTIARLTLGGDVRVSRSLAVGPIITASVGQYTVRTGTQTLDITGVGTRDQGLTPVDDGFHALFTVGIRLAFLPL
>NC_017030.1|WP_014394937.1|2522375_2524511_-|ATP-binding-domain-containing-protein
MAGQEQELSPEALALIAEEEALLSRVQQALAEARRQAAERTLDTQGLMAQLAVLRDDATTAHAADLPHVFTQMNEVRSMLERQEAVPLPDAHAPYFAHLRLSGPTGARDYLLGRTSFANLSAGVRVIDWRFAPVARVFYNYEEGDAFEEYFGDRLSEGEVEARRLVIIEKGVLTRISTGPYLLQRDSHGRWHSRGRDAASVLAGGSGTAARPGFLGVGRGETHVEDAFGVTALLDAEQYAAVSTGPEQPLLVLGSAGSGKTTVALHRLAKVVFDDAKTFPQARTKVVVPEEGLARLTRRLLAPLGLGKVSVETLEAWSLATARSAFSVPGIKLSPDTPALVSRFKRHPALRRALAGRVPVFKGKALPPTLDRLRIKLADAYMDRAFLEAVVADAKGELPRTVVAEVMEHTRQQTATPLSRQYKGFDEDRLVTVDGRAIEADTPDALAGTVDADDLPVLMFLKAQRGALGAERLAHVVLDEAEDFSLFELFVVSQLLGDSRSCTLAGDEVQQTTAGFAGWDAALDELGIRDAATCRLQVSYRCPRPVVELAQHVLGTQSPATAAKAGREGAPVGFHHFPDEAQAWLFLGDALRDLVLREPHASVGVIASSREAAQSFHRVIREMPWARLVLEGDFSFEPGVDVTDVDNVKGLEFDYVVLPDVTARAYPADDEARRRLHVAVTRSSHQLWVASSAVRSPLIRTFPGADALSQG
>NC_017030.1|WP_148282520.1|2521755_2522385_+|hypothetical-protein
MVLAVGAWLVFGGQAPEDAAPAPAPAPVTQAPAPPPVFASTPAVPRAKDGGLDLVGAATAQVQAAPDEEPAPYPVDLEALRAKLPGNLYFELDAPTKDPEELRRREGVKAKWNALYGKVLSNEASEEEVHQYYEHRRQVSEDAIAFATTMLQDYGDKLPSEHRGLLELSVNMHRTRLAEIPRQESEALSRREAHAQRQKEWRAGGGRQP
>NC_017030.1|WP_014394935.1|2520118_2521423_-|hypothetical-protein
MRSFLWMSLLALSAPVGAAHAEVLVEGIVDVLVDGGNTYPWQKVTLPGLKCGNGSQYKFFVHKTNSPNLLFMMEGGGACWDYDSCSGRLGILGAANPNGIADDYMTQFTAKYVSPIVNGADPGLPFRDRRDIVTKGWNIVYLPYCTGDVHIGNNAKTYVDTTGGQAPLTWYHNGYNNTLAAANYAKQNFPNVQKLLVTGYSAGGTSTSAGYYFIRKAVNPAKGYMINDSGPIFMAPNANSLSRPLHNQIRSSWNLDSVFSQLPASFNINDMGSINKMVATEFPNDQLAYTGYTLDYNYSRYSYERFKTPNDQASIHAYWKQDQDAFVNELNKYNNFSYFIPHHRAINQSHCSTIITFVGAHACQRMEKKYWYEYIDSPWQSWACHSEMVPMDVFLSRFINNNQRIRIYEPANNYNNEDAGMSILAPLINGALGG
>NC_017030.1|WP_014394934.1|2518647_2520021_+|DUF1552-domain-containing-protein
MPRDFSRRSILKLLSGTAMAAPFAHLLTSSVAEAADAAPLRFIALFTPHGLLPEYWLPKGNDTGFNIDFENSVLQPLQRHRDKLLVLDGLDYRVLYEHGRTGHEGGPVTFLTGSQVEVSSGDELPSNASLDQVIGNAVGGSTQFRSLQLHAFEQFGAQHVYNSISFTENGSRVPFELNPANVYKRLFASMGGSEAEAQAILSKRRSLLDYLIKDATRLKSRLAAAEGTKLDTHLAALRDIERRLTNSGALSCSTPAKPANTDLGDISNMPALTELHMDLIARAFACDLTRVVTMTIPGPSMPWIGIDEDIHNDIAHRTDTQSEPARTEIRLRMVAVQRWYSEQVARLMDTLKSIPEGSGTVLDNTVILWGNELGDAAGHMNVSIPTVLAGGAGGKFRMGRMLSLRAGKDPLGSWKGPGTPLEGAVPHNKLLTSIAQAFGVNVDRFGHDDYAGTLDLT
>NC_017030.1|WP_148282217.1|2517012_2518635_+|DUF1592-domain-containing-protein
MPLRRFYLSSALVLSASACTGNIGGQDAELESAAAPARVRRLTRDEYNKSASAVLGTEVDIAQGFAAEDTILGFSTHERLQVTSLLADQLDTAAVTLAEQGKSQLSDLYACPKGKTQDECARSFIQRVGERAFRRPVTAEEETDLLALFNEGKKGGTMATGAELVLQALFSSSSFLYRTELGPEGARKGQVVELTAYELASELSFMVTGGPPDATLLASAKAGTLSSPDEREAQARRLLKTEAAQVKLRQFFVEWLGLGGLAKVNKNNLVYPDYSVDFRDSMVRERDAFLDFIVKEHSGSVAELLGANYSFVDETLANFYGELERTNVDDTTGLGRVTLPPERLGILTQAGVMSTYAHFDSSSPIKRGKFVLTRLLCRTVPAPPANVSTIPPALSEDATTRERFAAHTDNPACASCHKVIDPMGFGMEDFDGLGQHRTEENGKRVDASGAVIARDGTTNLGNFTGGAQLARYLTTSEELANCVPLQFVRYAMGRDEHASDAELLAAMRTGPYRTGGLKITEALVSLVRSSSFTQRRLPTR
>NC_017030.1|WP_014394932.1|2516406_2516817_+|SET-domain-containing-protein-lysine-N-methyltransferase
MNLGPALFLHPGVKVRPCEWGMGVFTDTFIAAGELIEECHYLKVPQRLCRGEPLDDYVFEISWHRHEQHRPGNWVALVMGYGMIYNHASDPNAEYGRAEDRDVFRYHALRDIHPGEQIFISYGDNWWKARGEEVPP
>NC_017030.1|WP_014394943.1|2532323_2532812_-|8-oxo-dGTP-diphosphatase
MPYTPIVATLGYVMSPDGQQVLLIHRNARPEDAHYGKYNGLGGKMERDEDIAACMRREIREEAGIECTRMVLRGTLSWPGFGKHGEDWLGFIFRIDAFEGTPLEKNAEGALSWVPVSSILSLSLWDGDRHFLPLVFDADPRPFHGVMPYEGGRALSWSFTRL
>NC_017030.1|WP_014394944.1|2532865_2534398_-|hypothetical-protein
MKRHFALALLPVLSALACVSPDTELGESEQAATTPLRQKALGRMRNAAKYFHDNVARHGGYAWHHNATNLNERWGDIQLDADQIMIQSPGTSDVTIAFVEAALSDPATPALKTYALDAAMALRHGQVKSGGWRLYADFKPTPTIKACYLNTTASCGCGGCTVTAYDDQVTQNALIAMMRTDQLLGFANTDISGSSAYARARVETSQFPTNGGFPQGFAGPVAARPALSASYPPSIGTSCGLANCYANSYTTEYWDDPTLNDNLATSFVEMLYWAKEIYPAQAATYQSMRTAFGDFLRRAQMPQPQPAWAQQYDLQMQPRWARSWEAPAIAGQESQDVMWALLRLYQLDPGVPANRAAVGTALAYLETVDYANDTLLSRYIELDDTAPSNIGFYTVKAGGYPAQFSTAPPTYQNYAWEVPSQLAAIRAEYNRLATDTTVMKRSCQQLRADTAQAVDTAVNNERWITTYSPGGPRSGATPGDYLDTSTFARNLRTLAEFVTRTTTDCTAWNY
>NC_017030.1|WP_014394945.1|2534564_2534975_+|hypothetical-protein
MGLAERRAAKEFETKRFPQFKKDIDEAAGFEVPVTVAWDTLALEGESHLYDQCWGQVYFVPLIEALKGITIDDMGKEALKGALKQIEIQNRSDISYGERMATFEGGILRLDHRPHTNIDDVKDRTKGIQTLLESKL
>NC_017030.1|WP_014394946.1|2535027_2535237_-|hypothetical-protein
MMTSLKKAGRVLFAMGAGAFVSFGATLALSTPATAEASQVECYAEECNASCVAKGFRLGKCYKAACTCF
>NC_017030.1|WP_014394947.1|2535289_2536507_-|PQQ-dependent-sugar-dehydrogenase
MRHGLVTSFLASLLLSAAPEAQAQKPQPLETAPPNVPEFKPAFPQQTRAPAVKTRTPIVVTEIASGFNKPWAIAFLPDGRFLVTEKPTGKLFIVTAAGKKSPPVAGLPKVDGRGQGGLLDVEVGPDYAKSGLIYWTYYEPREGGNGLAVARAKLVDGPKPRIEGLQVIFRMQPTLESTLHAGGRLVFTPDGKLFVTLGERSILPGRVQAQDLKSDFGKVVRINPDGSIPQDNPFVGRKDARPEIWSSGHRNILSAALDAQQRLWIVEMGPRGGDELNRPEAGKDYGWPTIGYGEEYSGAPIHKTTQAAGMEQPVYYWDPVISPSGLTIYSGALFPEWKGNFFIGGLSSQALVRLVLKDDRVVGEEHLLTERNARIREVVQGPDGALYLLTDDSNGRLWKLTPGTP
>NC_017030.1|WP_014394948.1|2536538_2537711_-|hypothetical-protein
MANRHRVYLVPGFFGFTQMGDKETERIAYFQNVPRLLEQRFHERGIDARVHAIASAPTAGLEARARDVFREMARTANEDDAQLHLVGHSTGGLDARSVVSPRMAREAPDFVKRVRSVVTIATPHHGTPLASYFDQGGVGKTLLRYLWLFTFLTLHRKAMPLRTAALQACYWLVLRSEEAKLPPNLFNQVVRLTADLSEAEREDLIRFFGQVGENQALIQDLMPVRMRGFNADTADREDVRYGCVVTGAPPPRLSLHLLLTPDALLNGLFAFLYAKSAPLSRELQIPERTPAQTQALQDVLGRRFESKSDGIVPSRAQVWGEVLHVAKGDHMDVMGHFDQPPEYISWLKSGSHFQEPQFRAMWDRVIDFTVGGAATVHPGNEEAQRMSIDG
>NC_017030.1|WP_014394949.1|2537808_2538477_-|DUF4476-domain-containing-protein
MNRIVRAALVSSLFVSSASFAQDAEFNMQVDIDDQDMPSARIKMKTTTNVDGEETTTVKVRGGGARMDVRMTGGTMESESHSEHRETRTTETRREPRMDSRPEMAAEPSHRDCGTRSDEGCMMRRDGQFPMDASTWSGFYQSLKSESNEIVRQEKAEKMLKRVYLTAVQFGMVLDLFNNEITRLEVAKEAAPHVVDPQHALGFSSKWRNSISGSEYTDIITQ
>NC_017030.1|WP_014394950.1|2538696_2539395_-|carbonic-anhydrase
MKKLIRGLLDFQRHTLPSYRATFARLAKGQSPDCLFISCSDSRVVPNLLVSTDPGDLFTVRNVGNLVPPAKPGGQPSADRGEAAAIEFSLGFLPIEDVVVCGHSSCGAMKAILAGGTVDGAPNLEQWLAHGTPSMKKLRESNSKVGEGLPDADRLSQLNVLEQLEHLKTYPIVRDRLAAGTLRLHGWWFDIGAAQVHAYRADLGRFVPIDETEGDRLLTSLSEEPPALRAVQ
>NC_017030.1|WP_014394951.1|2539391_2540963_-|SulP-family-inorganic-anion-transporter
MTSDVKAAEARPSLKAILASDLPASLVVFLVALPLCMGIALASGAPIMAGLIAGVVGGLVVGFLGGVPLLVSGPAAGLAVMVFGFIQQLGFAVTCAAVAAAGLVQVALGGLKVARSALAISPAVIHGMLAGIGILIVLGQVHIVLGGSPQSNAWNNIRELPGQILNLHGAATLLGLMTLGILIAWGFLPNGRLKKVPGPLVAVLGGTVVAAVMNADVARVQLAADALSAIKLPSLPEGSMWGAFAVAVFSLALVASAESLLSAVATDKLHTGPRANLDRELLAQGVANTVSGLLGGLPITGVIVRSAANINAGAKTRWSAIMHAVWMLAFITLLGSLAAYVPLTVLAGLLVHVGLKLVNLAHIRELRHRGELPVYLITVAGVVGINLLAGIGLGLGAAILRLLWQLGQVRVEIHADKGVHQVCISGALTFVGVPKLSTALAKIPSGAKVEVDVAVNTLDHSGFEALESWADTHRKTGGSVRMEPLEDVWTRRSARAALATGPAASSPSSPVHHVSTLSPGGVQ
>NC_017030.1|WP_014394952.1|2541143_2542496_-|sigma-54-dependent-Fis-family-transcriptional-regulator
MSTSLLLVDDDRTFSSLAASMLSQEGFRVRVARSLHETRVALAAEAPDLVVLDRRLPDGDGLVFLPELRAQLPTTVVLMVTAHGDIESAVEAIRAGARDYLSKPVEIDDLVMRARRAASDLQLQERLRQAESVLEGRHRMAESRSPAMQRTLQMLERIATTPRSPVLLLGETGTGKAVLARHLHALRQKQGAFVQINCAALPDTMMESELFGHERGAFTDAKTARRGLVELASDGLLFLDEVGELPLALQAKLLTFLDKGAFRRLGGMTELTSTARIVAATNKDLEAEVTAGRFREDLLFRLSVFRVDVPPLRERREDVLPLARTLVQELCSELGRRPVPFSPAAEERLVSYPFPGNVRELRNVLERALVLELGPALELQSLAKGGGAPAAVDPNAFSVSGPPRPLDEVERLYVRHVLEQLGGRRMEAARALGLSYPTFLRRLEENPPSE

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Crispr_ID: NC_017030_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_13

2628244-2628348

Orphan

Consensus_repeat	Method
GCCCAAACCTGTCCGACTGTCGGACAGGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_13

>merge|NC_017030|13|2628244-2628348|CRISPRCasFinder
GCCCAAACCTGTCCGACTGTCGGACAGGTTTTCGCGGCCCGGCTGAAGGGGGAGCCCGTCCTGGCCGACCGGGTTGCCCAAACTTGTCCGACTGTCGGACAGGTT

>NC_017030|13|11|2628244-2628348|CRISPRCasFinder
GCCCAAACCTGTCCGACTGTCGGACAGGTT	TTCGCGGCCCGGCTGAAGGGGGAGCCCGTCCTGGCCGACCGGGTT
GCCCAAACTTGTCCGACTGTCGGACAGGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014395016.1\|2632358_2633822_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236145
NC_017030.1\|WP_014395018.1\|2634642_2635074_+\|YciI-family-protein	unknown	unknown	gnl\|CDD\|226318
NC_017030.1\|WP_014395009.1\|2618775_2619792_+\|phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270703
NC_017030.1\|WP_014395005.1\|2615145_2615808_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_017030.1\|WP_014395006.1\|2615804_2616647_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|236206
NC_017030.1\|WP_014395020.1\|2636377_2638921_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|223256
NC_017030.1\|WP_014395025.1\|2643081_2643705_+\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NC_017030.1\|WP_014395007.1\|2616780_2617554_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|180773
NC_017030.1\|WP_014395013.1\|2623006_2624368_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_017030.1\|WP_014395008.1\|2617570_2618773_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173844
NC_017030.1\|WP_014395011.1\|2620160_2621786_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275380
NC_017030.1\|WP_014395021.1\|2638939_2639713_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014395010.1\|2619784_2620150_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014395023.1\|2640612_2641410_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014395012.1\|2621914_2622985_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_017030.1\|WP_014395014.1\|2624488_2625562_-\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|239583
NC_017030.1\|WP_148282525.1\|2640036_2640609_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_017030.1\|WP_014395019.1\|2635142_2636258_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|224594
NC_017030.1\|WP_014395017.1\|2633912_2634464_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014395024.1\|2641396_2643082_+\|caspase-family-protein	unknown	unknown	gnl\|CDD\|334197

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014395016.1\|2632358_2633822_-\|SDR-family-oxidoreductase	gnl\|CDD\|236145	PRK08063, PRK08063, enoyl-[acyl-carrier-protein] reductase FabL.	2.44527e-63
NC_017030.1\|WP_014395009.1\|2618775_2619792_+\|phosphotransferase-family-protein	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.70825e-65
NC_017030.1\|WP_014395005.1\|2615145_2615808_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.25708e-12
NC_017030.1\|WP_014395006.1\|2615804_2616647_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|236206	PRK08260, PRK08260, enoyl-CoA hydratase; Provisional.	9.2286e-111
NC_017030.1\|WP_014395020.1\|2636377_2638921_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|223256	COG0178, UvrA, Excinuclease ATPase subunit [DNA replication, recombination, and repair].	0
NC_017030.1\|WP_014395025.1\|2643081_2643705_+\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	0.00498972
NC_017030.1\|WP_014395018.1\|2634642_2635074_+\|YciI-family-protein	gnl\|CDD\|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	3.72378e-42
NC_017030.1\|WP_014395007.1\|2616780_2617554_+\|SDR-family-oxidoreductase	gnl\|CDD\|180773	PRK06949, PRK06949, SDR family oxidoreductase.	5.25895e-77
NC_017030.1\|WP_014395008.1\|2617570_2618773_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173844	cd01155, ACAD_FadE2, Acyl-CoA dehydrogenases similar to fadE2. FadE2-like Acyl-CoA dehydrogenase (ACAD). Acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACAD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. ACAD's are generally homotetramers and have an active site glutamate at a conserved position.	1.90974e-88
NC_017030.1\|WP_014395011.1\|2620160_2621786_+\|hypothetical-protein	gnl\|CDD\|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	8.95058e-19
NC_017030.1\|WP_014395012.1\|2621914_2622985_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	2.49723e-06
NC_017030.1\|WP_014395014.1\|2624488_2625562_-\|fatty-acid-desaturase	gnl\|CDD\|239583	cd03506, Delta6-FADS-like, The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases are required for the synthesis of highly unsaturated fatty acids (HUFAs), which are mainly esterified into phospholipids and contribute to maintaining membrane fluidity. While HUFAs may be required for cold tolerance in bacteria, plants and fish, the primary role of HUFAs in mammals is cell signaling. These enzymes are described as front-end desaturases because they introduce a double bond between the pre-exiting double bond and the carboxyl (front) end of the fatty acid. Various substrates are involved, with both acyl-coenzyme A (CoA) and acyl-lipid desaturases present in this CD. Acyl-lipid desaturases are localized in the membranes of cyanobacterial thylakoid, plant endoplasmic reticulum (ER), and plastid; and acyl-CoA desaturases are present in ER membrane. ER-bound plant acyl-lipid desaturases and acyl-CoA desaturases require cytochrome b5 as an electron donor. Most of the eukaryotic desaturase domains have an adjacent N-terminal cytochrome b5-like domain. This domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain the residues: HXXXH, HXX(X)HH, and Q/HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homolog, stearoyl CoA desaturase.	7.75041e-24
NC_017030.1\|WP_014395013.1\|2623006_2624368_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	2.22748e-24
NC_017030.1\|WP_148282525.1\|2640036_2640609_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	4.20319e-21
NC_017030.1\|WP_014395019.1\|2635142_2636258_+\|serine-hydrolase	gnl\|CDD\|224594	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms].	1.8125e-31
NC_017030.1\|WP_014395024.1\|2641396_2643082_+\|caspase-family-protein	gnl\|CDD\|334197	pfam00656, Peptidase_C14, Caspase domain.	1.32472e-10

>NC_017030.1|WP_014395014.1|2624488_2625562_-|fatty-acid-desaturase
MTDFSSSLPMPPDDAKRLRSELRRVLPPEAFERQPLRGIVALCLVPVEAALIWVLGTWTLPHWACLLIAFVLGQLVTAVGLAAHEALHHSVFHSRKWESLLGWVGFAPFLVTPGNWRAWHVQAHHSAANVLVRDPDILPRRTDWHTQGFAKLFHAMSPGSGHWLSFISFSVFFTAQGQAFLWHHCRLPAFQHVHLHRARERVLTVLVTAGWVALGWVLGPRAAFYALVLPLLIGNVTLMIYIATNHWMQPAAEETDNPFVNTASVETHPLMNWLHFNFSYHQEHHIFPAQSPKYAPLLRKHLRELSPRASIVYPHLHALRTLYRRPALYSADGQSLMGRDGTREVSTTELRRQLEAT
>NC_017030.1|WP_014395013.1|2623006_2624368_-|FAD-binding-oxidoreductase
MRTESVTGGPRVEIPSRAEALHEAKVEAISQQLRQRKGKGPASFKKKSPPHSVPKRFDARRRDEKVDLGDLDAILDIDPVGMTCTAEPAVTFDEVVRATLPHGLIPFIVPEHKTITLGGAIAGCSIESMSFRQGGFHDTCLEYEVITAKGDVLRCSPTNEPLLFQMMHGSFGTLGILSKVRFKLTRCTPYVRVTNETHSTLESFQQGIWHHFQEPGADYLDGQIFSPTKHVLCVGHFVDRAPYVNRYDWLTAYCESIPRRSEDYLPTYDYLFRYNRGVTHVKPKNLLARALFGRLIHSDSVLRTANRFTQLLPKKDPPVIVDVFVPFSRTAAFMDWYHREMRHSPVWCVPFRRTRDYEWLTPQWWSGMKDPLFLDLAVYGMPQPPGRNVYKELEEELQRVNGTKTLISYNYYDEQTFWSIWNRETYQAVKQRTDPDNLFRDLYVKTCKAALGL
>NC_017030.1|WP_014395012.1|2621914_2622985_+|hypothetical-protein
MSISSLNRASSFQPSSSLSQLKPAAAPAQGVMGTSAQQPRNDLRRMLMTDSFEAGPSRLGGASGGGFEKQLSQLVSQLSQLVQMLQMQSPAGQGQGAEGAASAVGGVGGAAPAQKAASASSASTFEGPAASAAAPAAQGAAPASSASAPAHPTYNSDAGPGFGPPSAGSTEPAPANAPWLAKNNVGSPYNSNMQLIDESQKGQFKYTNTFTNKTNEPQTITLWNKTGENGNPNDGQNFDKSTPKTFTLQPGQSQVVAFDSNTSVAWAASKDGTAKPGANSGQTWGEATFANSGTGWSGFDTSQIAPAGHNGKMSITNEATGKTVTEANAWQTEKDDPALHDVGVPAGPLNLRTEIG
>NC_017030.1|WP_014395011.1|2620160_2621786_+|hypothetical-protein
MKKKASPSPARDLPFEILTWSQVRDEVKAPGNREDDWDRVLVLTGNVVMPYDLGLDFHQGIFAQDDEDAPPFTGLIVRGDLTVEGCVLNWENDFGPFLQVHGNLVAKRIAIGGARLHVSGDVTTEDLVAVYNHGSVSVGGNLKARTLASHYSFNVAGAVDAHRYLGQDSKVFAVAGGVEDVKDPYEGKGVFVPAVVRDGRVDLEKVRARLAAGKPVARDAFTSIREAFRQLVAKKIAEPDKVKSLTLEDKGLTSLPEELFLFRKLEKLNLRRNNLRVLPEELGQLTELRELDLRSNGLLELPESIGELKKLRVLDLEANCLWRLPESLAGCVELRRVNLINNPHAYVRRAFGSWKQVQLMFDFPEVLTRLPKLEVLTFEGTPLRTLPTRRFDSTALSKATVLRSLVTQVDPELHAQLQVDVERSREKAAAYIGYWFKPETVSLESFYDAKTDRYDFAELLALLALLLRINIPTAAPYEEALAKFRGQSQGIARYLDWDGDKPRHVHALFGALRDALGPLGEPYPGDALIAGLRDVFAAHAG
>NC_017030.1|WP_014395010.1|2619784_2620150_+|hypothetical-protein
MREQPDGAALLAIAREVLLRELLPGLPEDKVYAARMIANAMGIAERQLRAGEGPAQEERGALVALLQREGELAELNRELAARIRQGAFDGNREAWSLLWDSTIQRVRESAPKALPASDRMG
>NC_017030.1|WP_014395009.1|2618775_2619792_+|phosphotransferase-family-protein
MREEHKHALESFLATKAEAREVRLIDARLLSGGAIQENWLLTAAVSGGPHDGVLECVLRSDAASGVSVSHGRAQEFALLKEAFRAGVTVPEPLWLGDSSVLGRAFFVMRKARGTAAGHRIVKDLGLGGDREALTERLGEELARLHAIRPPVEALSFLPVPALSPALRGVKEFQSFLAGHHTAFPALEWGIRWLERHAPRTPELVLTHRDFRTGNYMLDEAGLTAVLDWEFAAWSDPLEDIGWFCARCWRFGQFDKEAGGIGSREALARGYARVSGRQLDWASVRYWEVFAHARWAVIAVQQGERHVSGREPSLELALTAHVVPELELELLSMTGGRNA
>NC_017030.1|WP_014395008.1|2617570_2618773_+|acyl-CoA-dehydrogenase-family-protein
MDFSLSPEIEAYRLRVREFVATHVLPLEKQPDAFDAHENLREEMVARVRELARAQGLWAFQMPKARGGQGLGVVGMAACYEEAARSPFGPVMFNAAPPDDGNMIVLEKVLATEALKQRWLQPIIDGKVRSAFAMTEPDGCGSDPSLTYTRAEKQGGEWVLTGRKWFITGAQGAQHFIVVARTSDDERKGLTAFLFDASQPGWRIERRIPIMGPEEHGGHCELVFEGLRIPDEHRLLGVGDGLKVTQIRLGTARLTHCMRWLGLAKRCLEEAGGYVSRRMSFGETLAQHEGVQWMLGDAAKDIHIGRLLTMSAAWKLDQGDFARTDISIAKIHVADALHKAADTAIQLMGARGYSKDTLVEWIYRYARQARLVDGASEIHKMVLSRAYLAEGADFFRWGVG
>NC_017030.1|WP_014395007.1|2616780_2617554_+|SDR-family-oxidoreductase
MSVDAFGLEGRRALVTGASGGLGLHFAEVLARAGAEVVLAARRADRLAAEVERLRELGLRAHAVSMDVTLAASVQAGVAEAEALAGGVLDVLVNNAGVSGEGFFLQVEEADWDTVIDTNLKGSYLVSRTVARRLVEQGSPGSIIHIASILGLRVAGGVAPYGASKAGLIHLTKAMALELARHRIRVNALAPGYIETDFNRTFFAKDAGQKLLARIPFRRLGHMRELDGPLLLLASEAGSYMSGSVIEVDGGHLCSTL
>NC_017030.1|WP_014395006.1|2615804_2616647_-|enoyl-CoA-hydratase/isomerase-family-protein
MSYQHIRVSYADRVANVELHRPEARNGFTVLMADELAAALAAADADEAVRVVILSGAGKDFCVGADLSGQSLEVTNTDIPGGAWVEPATRVARQLFMLRKPVIAAIQGAAVGVGSTMILPADFRLAARNSRFGFVFSRRGIYPEAGSCWFLPRLVGLGRAMDWMVSGRLVPAEEALGAGLVQSLHEPEALADAAQALARELVDSTAPVSVAVIRQALYRMSALPSPEPAFALDSQLIASLGESADALEGVMAFMQKRPARFSRTVTQDLPTFLPWQEARR
>NC_017030.1|WP_014395005.1|2615145_2615808_-|TetR/AcrR-family-transcriptional-regulator
MSALAPRWKRLEPDERRQQILECAMRLFGERPYADVSTTDIAREAGVARGLLNHYFGQKRDLYLKVVKRMLLMPGIEKSVPMTGTLRERVERSVEWYLDTVATHGKTYLAVIGSGGIGADPDVERIIAEADDVAASRTLEFLGLKAEVGNDSRQRAMIRSYGGLVKSSIREWLRDGTLSREETHLLLSESLLLIVRDLLPQLARTATPGRATPAKPKAQK
>NC_017030.1|WP_014395016.1|2632358_2633822_-|SDR-family-oxidoreductase
MSARSSQSHTSTPSNILEQVRQCAASVTRYPLDILTEHAQLEDELGIDSVKLAEIAAVIAREFQLPPDRLPRNGKARTLGAIAGAVTEALGTQPGPSLHVAAPVAPAPAVAEAKAGTGAPATQDLLPRVRAVFARVTRYPEELLTPHADLEDELGIDSVKQAEVMAVLMKELGLGDAPKPSQRLRTMAAIADAARALLPAAPPVAEARPRAPVVHAAPAPVVSRTDLPFAGKVALVTGSGKGIGRVIATRLARAGATVVVNSFHSREDGEKTARDIVDAGGKAVHLWGSVAQEEHLERMFAAIREQLGGLDLLVCNASNGLIGPFDRIAPRDWDKAFRTCITGTYECAMRARPLMAARGGGSIVTMSTSMSQRYMHDLGCQGVVKAGVESLTRYLAAELAPEGIRTNCVSAGPVHGDLLGMFPDAPERVARWESATPGGRLCTADDVADVTELLLGPKTQRVNGAIWVVDAGLSGTVDGLLPAARAS
>NC_017030.1|WP_014395017.1|2633912_2634464_-|hypothetical-protein
MHAGVTSPGTKPFPASGLLHPAVLVAVVLLVLNDHVFKARWPSWWTGKLSDVAGLAMFPVLLQALWEQAFQRRAREFRPSFPVLVGAVVLTGLCFGATKISSDAGDAWRWALGALQWPFYALRAGLAGTRIPSVRPTVHTVDITDLLTLPSLIIPLWLGWRRARVAREQGAHIPAREESSLPP
>NC_017030.1|WP_014395018.1|2634642_2635074_+|YciI-family-protein
MRFMIIRRADKDTEAGVMPDEKLLAAMGAYNEEMVKAGVMLQGEGLHPSSKGARVKFTNGKPAIIDGPFTETKELIAGFTLIQVKSREEALAWLKRWPSIDAGGNVELELRQVFEDDDFGAEFTPELREQEARIREQGAKNRR
>NC_017030.1|WP_014395019.1|2635142_2636258_+|serine-hydrolase
MFQRMVLLCAVWLLACGGKRVPTGPGSPPDRLDDGWAVASFEDTGMQRPWFDALEHDVSEGTVEAPDAVLVARGGQLVYERYWNDFTREKAHDLRSATKSVTSLLVGMAQERGLLPDLDAPVLPLLPHLAPVKNADPRKERITLRHLLQMRSGLSCDDWDPESPGNEERMYDTDDWARFIVDVPMRDEPGTVTRYCTGGVVLLGAVLEHVSGRSIPDLSREWLFTPMQVQDVTWQPAGKKGTDTGGHLRLRPRDFLKVGQLMLDGGAWQGERRVSEAWVAESGKALGPLGDANHGLLWWSARFVIQGTPVEVSFARGNGGQYVFVAPSLGLTAAFTGSYYNDAGSALPLVLFGQYVLPAALGLERPGARGG
>NC_017030.1|WP_014395020.1|2636377_2638921_+|excinuclease-ABC-subunit-UvrA
MAPPKAPRSRKTPDPSGFVRVRGAREHNLKHVDVDIPRDALVVFTGVSGSGKSSLAFGTLYAEAQRRYFESVAPYARRLIDQVGVPEVDAIDGLPPAVALQQHRGAPTSRSSVGSVTTLSNSVRMLYSRAGNYPPKLERLDSDAFSPNTPAGACPKCHGIGRVFEVTERSMVPDDSLSIRERAVAAWPPAWHGQNLRDILVTLGYDIDKPWRDLPKKDRQWILFTDEQPTVPVYAGFTSAEVKRAMARKEPPSYMGTFTGAKRYVMTTFATTQSAMMKKRVARYMVASDCSLCEGKRLKRESLSVTFAGRDIGELSRLPLEQVAELIKPTAEGKGKDADTMAREHPEKLIVAQRITKDLLARIQVLTDLGLGYLSLERSTPTLSPGELQRLRLATQVRSNLFGVVYVMDEPSAGLHPADTESLLTALDRLKEAGNSLFVVEHEVDVIRHADWIVDVGPAAGEHGGRVLYSGVPEGLAKVEASRTRRYLFEEEALRRREPRKPTGRLRLEGVKRNNLRGLDVDFPLGVFTTVTGVSGSGKSSLVSQALVELVAGRLGQTLAPEEEEGEPLDREPVMASEGHIQEGMESIRRLVTVDQKPIGRTPRSNLATYTGLFDHVRKLFAATPLSKSRKYGAGRFSFNTAGGRCDTCEGEGFVSVELLFLPSVYAPCPTCHGTRYNAKTLEVRYREKNIADVLGLTVDGAFDFFTEEPPLQRALKVLRDVGLGYLRLGQPATELSGGEAQRIKLATELQRTQHGDTLYVLDEPTTGLHPADVDKLMTQLEGLVDAGNTVIVVEHDLRVIAVSDHVIDVGPGAGNAGGRVVAQGTPEQVAKVKESRTAPYLARVLR
>NC_017030.1|WP_014395021.1|2638939_2639713_-|hypothetical-protein
MRRFIGLFASLMWLSACGNSTSSVGLSTRMGSAVTGSALTRTSSQRLVLSNGITVDRVRLSVRELELKREGHHDDSSDDDSDAGTDAGTDDKSEHKQRTGSFLIDLSGTALEGQLVRLQDISVDVGTYDEIEFDIGKVDPANATGGLKELADQGASLIIDGHIDGEPFQFVSSLRVEQEREVSFEIAEGDDQNVTFNIDPSGWFTDKDGKRLDPRESSARSELENNLQKSIDAFDDHDRNGGEDDDDNGSHHDGKDD
>NC_017030.1|WP_148282525.1|2640036_2640609_+|sigma-70-family-RNA-polymerase-sigma-factor
MTEQELADCIRRAARGDQSACGQLYQRFHGAVRRVAQGSGVLGAAEVEDAVQETFVRAFRELPRLQHPRAFSSWLLTIARHHAYALSRGAKARARVEEDLARELDTVAPALPPSLTLERRVAVVRALIEGLPEGPEKETARLFYLEGELSAREIADRLGLGKSAVTMRLERFRARVKRELLARLLAAEVG
>NC_017030.1|WP_014395023.1|2640612_2641410_+|hypothetical-protein
MGASDRHLDVESAKQLERREPEAVRYFAEHLSHPCETCEAFLARDDAEPGELRGVDALADEALVAASDRPVREDAVGWARVRRKLRAPQRVWVTGGLGAVAAAVLLALVVRPGTGGPGSVEAPSQRIKGTAPLALELTAVARLPTGEVRAVAPDAMLPPEAVVLLRYHASESADALLVRESPGVPPQVLGRHALTPGTHDLRDGEDLAGVSLEDERGPVTLVLVAWPHGEQGNAALEVVRVSGQVPPDAAQARLRLKVESGHAAP
>NC_017030.1|WP_014395024.1|2641396_2643082_+|caspase-family-protein
MLLPEEPRVSRLLFIPVVLALVVLGACRSVEPREKGRAVRVRLEDGVLASAQEGERHALLIGISAYTDPAWNGLRYAAKDADDLGRVLADPARGGFRSVTVLTRPEQTTRTSVLAALQALEARPWRPQDTVVVYVSGHGSLARDVRGELQRYLVTSDTRYRDVAGTGLDMATLEQSLERLGSRRRVLVLATCHSGTGKSLLPPEVRDELAHTKASFLPQPLEAASRASLVLSASDWGEAAREDDALANDIYTHFLIQALDGSGDRNRDGAVSATEAHDWARRNTWAYTEGRQRPSAQILEVGADPVLLSGSLQRPGQPEVFSYSARLEGFTLKVDGHDAGELPGGVVVPEGRRKLELRKGGQVLWEDTVALRSGERRELEAFLRPIADGPKRTVTLGGGVLGFLDGQSRQQVLPASAQAGVGLGWEGVLLDGKLDLWVDVAAGQGSQSLRLDPGGDVPVRHRTLLVGVAVGPTWTWGRLGLSTGPRVAGLWLQRSFQLELLDRNEQYVTAWPGWMAALSFRFSPVWMVEARAQALWAYVPVDGQTRTVGFGGLMLAGGYRF
>NC_017030.1|WP_014395025.1|2643081_2643705_+|carboxypeptidase-regulatory-like-domain-containing-protein
MRARTCGGALVLALVGCGGFENGDLRTGTVRGRVLGAESGVARVSVLGHEELRATVAADGRFELDGVPAVSLELYVVASRTKAARTPVLAQGARVTDVGDIQGKPGAFLTVRVRDEQGAIPPDVEVELRGTGEDRAKVDTSSGEVRLGPLPAGCYALEVKADDLEDVETEVCVREGEERLQPITLPADDDGGGDDDGGDDHGGRDGG

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Crispr_ID: NC_017030_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_14

4718906-4719006

Orphan

Consensus_repeat	Method
ACGTGATTCTGGCCCGCGTGCATGACGGGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_14

>merge|NC_017030|14|4718906-4719006|CRISPRCasFinder
ACGTGATTCTGGCCCGCGTGCATGACGGGCGGCGGGCCCTCGGGTGGCGGACCTTCGCGCGGCGGGGGGACGTGATCCTGGCCCGCGTGCATGACGGGCGG

>NC_017030|14|12|4718906-4719006|CRISPRCasFinder
ACGTGATTCTGGCCCGCGTGCATGACGGGCGG	CGGGCCCTCGGGTGGCGGACCTTCGCGCGGCGGGGGG
ACGTGATCCTGGCCCGCGTGCATGACGGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014396598.1\|4713030_4713444_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014396601.1\|4716740_4717565_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014396593.1\|4706330_4707569_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182528
NC_017030.1\|WP_014396606.1\|4724247_4724763_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014396610.1\|4732043_4732859_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_043321541.1\|4722760_4724260_+\|glucan-biosynthesis-protein	unknown	unknown	gnl\|CDD\|377321
NC_017030.1\|WP_083892138.1\|4733718_4736004_+\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NC_017030.1\|WP_014396607.1\|4724812_4726837_+\|glucans-biosynthesis-glucosyltransferase-MdoH	unknown	unknown	gnl\|CDD\|235476
NC_017030.1\|WP_014396604.1\|4720756_4722211_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|236722
NC_017030.1\|WP_014396596.1\|4710542_4711121_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_017030.1\|WP_014396602.1\|4717576_4718398_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014396609.1\|4728532_4731679_-\|cyclase	unknown	unknown	gnl\|CDD\|226418
NC_017030.1\|WP_043321540.1\|4711124_4712753_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NC_017030.1\|WP_014396595.1\|4708812_4710468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|293787
NC_017030.1\|WP_148282569.1\|4713955_4715758_+\|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl\|CDD\|223107
NC_017030.1\|WP_148282293.1\|4736050_4738345_+\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NC_017030.1\|WP_014396600.1\|4715762_4716728_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223409
NC_017030.1\|WP_014396611.1\|4732863_4733676_+\|TIGR02452-family-protein	unknown	unknown	gnl\|CDD\|131505
NC_017030.1\|WP_014396594.1\|4707573_4708803_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NC_017030.1\|WP_148282570.1\|4727011_4728520_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349910

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_148282569.1\|4713955_4715758_+\|thiamine-pyrophosphate-binding-protein	gnl\|CDD\|223107	COG0028, IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism].	6.43009e-138
NC_017030.1\|WP_043321541.1\|4722760_4724260_+\|glucan-biosynthesis-protein	gnl\|CDD\|377321	pfam04349, MdoG, Periplasmic glucan biosynthesis protein, MdoG. This family represents MdoG, a protein that is necessary for the synthesis of periplasmic glucans. The function of MdoG remains unknown. It has been suggested that it may catalyze the addition of branches to a linear glucan backbone.	0
NC_017030.1\|WP_083892138.1\|4733718_4736004_+\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	1.31624e-09
NC_017030.1\|WP_014396604.1\|4720756_4722211_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|236722	PRK10590, PRK10590, ATP-dependent RNA helicase RhlE; Provisional.	1.20328e-171
NC_017030.1\|WP_014396596.1\|4710542_4711121_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.89102e-25
NC_017030.1\|WP_014396607.1\|4724812_4726837_+\|glucans-biosynthesis-glucosyltransferase-MdoH	gnl\|CDD\|235476	PRK05454, PRK05454, glucans biosynthesis glucosyltransferase MdoH.	0
NC_017030.1\|WP_014396609.1\|4728532_4731679_-\|cyclase	gnl\|CDD\|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	1.54807e-33
NC_017030.1\|WP_043321540.1\|4711124_4712753_-\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.02297e-06
NC_017030.1\|WP_014396595.1\|4708812_4710468_+\|hypothetical-protein	gnl\|CDD\|293787	sd00044, HEAT, HEAT repeats. The canonical HEAT repeat consists of two helices forming a helical hairpin. HEAT repeats are found in a diverse family of proteins, including the four proteins from which its name is based: Huntingtin, Elongation factor 3, the PR65/A subunit of protein phosphatase 2A (PP2A), and the lipid kinase TOR (target of rapamycin). The HEAT repeat family is related to armadillo (ARM)/beta-catenin-like repeats.	0.0032786
NC_017030.1\|WP_014396593.1\|4706330_4707569_+\|ABC-transporter-permease	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	7.94076e-48
NC_017030.1\|WP_148282293.1\|4736050_4738345_+\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	9.91455e-12
NC_017030.1\|WP_014396600.1\|4715762_4716728_+\|hypothetical-protein	gnl\|CDD\|223409	COG0332, FabH, 3-oxoacyl-[acyl-carrier-protein].	6.47744e-31
NC_017030.1\|WP_014396611.1\|4732863_4733676_+\|TIGR02452-family-protein	gnl\|CDD\|131505	TIGR02452, conserved_hypothetical_protein, TIGR02452 family protein. Members of this uncharacterized protein family are found in Streptomyces, Nostoc sp. PCC 7120, Clostridium acetobutylicum, Lactobacillus johnsonii NCC 533, Deinococcus radiodurans, and Pirellula sp. for a broad but sparse phylogenetic distibution that at least suggests lateral gene transfer.	1.0052e-90
NC_017030.1\|WP_014396594.1\|4707573_4708803_+\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	1.63889e-53
NC_017030.1\|WP_148282570.1\|4727011_4728520_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349910	cd05660, M28_like_PA, M28 Zn-peptidase containing a protease-associated (PA) domain insert. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins containing a protease-associated (PA) domain insert which may participate in substrate binding and/or promote conformational changes, influencing the stability and accessibility of the site to substrate.	1.72475e-90

>NC_017030.1|WP_014396602.1|4717576_4718398_-|hypothetical-protein
MKCIVAVAVLATVLGTLPARAAPPAPVEAGKVFVGPQGELVSVVPLAPREQKKFLLRIQGTGSVLDNLVLPYTLKDWSSPSTLRHNYTTQWHGKDYSPLITVGKNTELHFPGGPGNGIAVQYDEARSQKLKPEEVYAQHQQQTQSGQLAKLMAFDRKAEETIHDTAYAEALQALNTTCGTSVAGAIDWTTIPEPVLKSQKIARYCASPLTALKALCEVSDEARTTVKARLKQMDCRFGATLEPALQGDRFVWTTTPEASQQEKAATRYFKKHL
>NC_017030.1|WP_014396601.1|4716740_4717565_-|hypothetical-protein
MLFQRILPVAVLLSASPAAAVEPPWGKAENLGQRMLLEATAVCTDGKGHYVVSVPREDTDELEDQLYYGDSKSLVVVPRPRSRNLNATTFLDPRFFNPNGTADYDGVDLRVHSQLSVDTKERTCSLRCGERKVTLEMLPSTQARELLRKATYVPNPQKFAPHALLRDSEGTYYYVDKGFTPAESRNFRVFIGPRGDLKPQKMTNVVADSEGEIFTTKKGQLRLVIDRAQKPIWIEKARKEVELRNVPVEQNLPLIYNELGVYTGIRLGTPCDDQ
>NC_017030.1|WP_014396600.1|4715762_4716728_+|hypothetical-protein
MSAATFALLGVGAAVPEQVRGNDDPLFEPLRRAAGSGGEHALFYGNRERRVLGPGESLAALTAKAGAAALQDAGLTAADVERLYGYVSVSEFIAPNELYAVHRELGLSQGALVVPVNADFANFLMGVVLAWEALRAGSIRHALVAVGSAWTRNVDYTQGHAIGIGDGAGAVVVGAGEGLTLVDWGADTFSDEYGAMMMGSRPESGLAYPTYGIAPAAGVKAFLNSGMNGPPRLVERLLTKHGVAREDVTLISHQATRKLMDHWAQEIRPREYLDTFEQYGNMVHASMPVTLARFRRELRTKYLVMVGLGIGAHQMALLVRV
>NC_017030.1|WP_148282569.1|4713955_4715758_+|thiamine-pyrophosphate-binding-protein
MEARHGDPIPMYGDVNARGFKTVEDITVADCVIAHLEAEEVDAVFGVPGGNIAPFQQALRKHKSMRFIIASHEGGAAFMADGYARATGKLGVCMVTAGPGATNALTGVASAHLDGVPLLAISGNIATDRVGLMAIQESSSTHGVNTVEMFRQACASSTGVPDAQSFQRLLARSMRTAQGLPGGAAHLSVPANIARQPIHRASVPTTRGAFRARPATAPFEDLRAAFTLLRTARRPLIFLGAGAREAMAEHAETFTAFVTQHGIPVATSMRGKGLFSEREALSLGVLGLAGSKRAEAYLRDGVDVMLVLGSRLGEWASRSFHRYFQAIHHVIQVDVNASNIGQFLPVRLPIVADVGSVMTGLAELGQMIGPSSGARVQERWAQVMALTEPAPVVRTPQDRDSVKPQDLMAELDKHLSPDMDLYIDMGNCTGWTSHLLHITPPARIFYPCGLSSMGWSCGAVIGGKVGRPDRSAVAIVGDGAFLMNGTEMITASRYRVGTVTIVLNDNFLGMVNHGEHVQDRTVPLEDDYYGLGNPDLKAFSESLGARAYTVNGPGQLDALLPEVLRRANETGQPQVIVAHIDYREVPPYGDRFAAVASDGK
>NC_017030.1|WP_014396598.1|4713030_4713444_-|hypothetical-protein
MAENLRTEYGFRLNAPGYITPAEAKAWFEDLRAKVAIKRGRPFGLMVDIRGQKANPPETQEIIKQAMGWLRQNGMVRSAVVLDSTVARLMMVRMAKQSGVYEWERYIDASKDSDWEHKAIDWITNATEPSKEEDAAA
>NC_017030.1|WP_043321540.1|4711124_4712753_-|hypothetical-protein
MRVYADVDHRARGLHWERGVAGWLQRASESVRGPLGITFELESARAWDRRGSDGPLEPVLDALEEVDAGEDVDLVVGLVAAPATFSGAQHELGFARVLGRHCVLRGLGGELPVEARQRLEVAVLLHEWAHTLGAPHVRDGRGWMSPKYDAGQTGFDARTLALLGAGLRHLPGARVELEAQKAWARELRVAVEAMTGPAWEGPERDFLLEWTERVRASSVVLGPEGTPHSLTPQERQRLAEVIALEKAGRPEVAAEALEPLAVRHPHNERVQLLACYLAVHVTPGLNATRERCERAIARFPREPSLRMNVALLHLHAGRFDEARDSLVAARTNLEARADVEPAQWADLAALFLRAHCVTWAEETAARAQGLAASTAVLEQAARLRRQVALPARSEARTAVVDPAREGALVRAVSDIEALLHAGSSGPARERVAALAQEYPASPSVTLLQCELHLFQGRLGSARTACERVLAFREDAVQAHLLLGVLATNTRAHARARKHLERVIALEPSRTEAWHLLAREYRGTRQLKTLQARYREQFARDLP
>NC_017030.1|WP_014396596.1|4710542_4711121_+|GNAT-family-N-acetyltransferase
MSMISVTLPLPIVPAPFRVRVFTPEDMDGVIALYSHPEVARSLNFTVPVPRETLHQKLTGDLEAMRQGKGIRWVLSKDEDPTPLGYLTLFNWSQKDRRAEVGYMVGRSVWGQGVMTGILPALIRFGFEQLNLHRIEGMVNVRNTASYKALTRAGFQQEGVMRGYQADGNGGGFNDIILLALLEDAWRASVAT
>NC_017030.1|WP_014396595.1|4708812_4710468_+|hypothetical-protein
MGDALAEARRRASGDDLASLRRLDALMVRSGFRHADRTPREWVAELVAQGKSRRGDTYDAHEALRAIGLGAVPALLEVLATPQLAEKESADANIRLNVLEALMAPRPPPRCAVPAVLGLLSRRSARVQRQGMRALVSLRPRPTRLAVRLLLEACQDKTQWQARATALDALAALDGPVPDDVLHEALKRLSDESPYVRRSALRLLGRCTPPSEEVLHALEEQVVLDDESRVVVLQVLSWLSPSRALPLLDRTARGLVGLLPNDRDGARQGLFALHLLAGMGARARPAVGLLRRVVTHAVKRGHGDPFAWRMRVHAESVADAIVRCAPLPVEARTPGAGSPRLALALAGAGPLPVDAEHPDSARLQAWVDSLGPLSQEEEVRLCVAVARVAARVWDRHGPENDGAQSSLLALEEWVLAPDEAHQRRAMEIGLFVPSQLLASELFNAAWCLHYATLMVADAEKRHVGFTGLTPKEPEHLLATCAFAAYRALRSGACMTVDEGWRDSTLTWQRTPDEALAFLHRAMVDEVLPWARGEWDPLRDVLRERRRLLMEE
>NC_017030.1|WP_014396594.1|4707573_4708803_+|ABC-transporter-permease
MRAFLDNLRLALGTFLGNPLRSLLTLVGIVIGVATVITMMALIEGLREQVNKNLGSLGAHTFEVTKWPTGFGRINWAKYAKRKDLLGDDVRAIVESCPSVGAATPTSQEWGKKLTTAFRETPPSVSVLGTEPTYLETSGVVVSTGRFFNETETLDGRPVMVIGVDLADTLFPGMNPVGSEVRLQGRPFQVIGVLQKRGSVMGMASQDNQAIVPMRAFQQFYGKNRSVEIDIQARDGESFQKAQDEVVNLMRRRRGLTPQEANDFEVHTNESMTASFNELSQVIAFAGVGVCLLSLVVGGIGILNIMLMSVTERTREIGIRKALGARRRRILGQFATEAVMLSLVGGVLGLGLGFGFVFLGKWVLLFPMSVPMWAVLLSLGMSCGVGLIFGIYPASRAARLDPVEAMRAE
>NC_017030.1|WP_014396593.1|4706330_4707569_+|ABC-transporter-permease
MSFRRVFRVDVLEGARIAVFSLQANRMRTVLTTLGIGIGVATLLAIVGIIQGLNSSFEKQLATLGANTVFISKYPWMIKGNWWIYRNRKNFTLEQVAQLRSQADFITAISPAVMRMSDVAHGALQVSNVRINGVWSDYQAIGNYEVVSGRFLTRADEEVNRAVTVLGADVAASLFPSISPLGQTVRIDGRPFQVVGTLGRKGKVVAENMDLSVFMPFKTFNSHFGKGRPMQIAIAVADAGQMAKVEDQLVGIMRRVRATPPGQADDFNVNRTDSLAATYEQLTGALYAVATGVGLITLLVGGIGIMNIMLVSVRERTREIGVRRALGARQRTIVLQFLMEASSVSAVGGLLGTTVGLGTAKIVSLVTPLAADVRPSTVVGGVAFAALVGLLFGIWPAARAAKLDPVEALRYE
>NC_017030.1|WP_014396604.1|4720756_4722211_-|DEAD/DEAH-box-helicase
MTFDELQLTDSLLKAVKAEGYTTPTPIQAKAIPHALAGKDVLGVAQTGTGKTAAFALPILQRLSAKAPAGGARPVRCLVLTPTRELASQVSDSFATYGKNLPLRHAVVFGGVGQNPQVQALRQGVDILVATPGRLLDLIDQGFVTLRALEVFVLDEADRMLDMGFIHDVRRVIKVLPPVRQTLFFSATLPPDIMDLARNILKEPVRVEVSPASSTADTVSQQVYFVEREEKRALLTHLLQDAKAIPRALVFTRTKHGANRVAKQLTAAGVRADAIHGNKSQNARERALDEFRAGTLRVLVATDIAARGIDIDGLSHVFNYDLPNVPEQYVHRIGRTGRAGASGQAVSFCDSEERAYLRDIERTIRRSVPVVADAAFRSHLPPPLPGDVEESRPPMNRGGRGQSRGGGGGGGGGQRRGGGQRRGGGGGGQGRPNGGQPRQASGGGNAQAPRSGGQGRPQQARPAVASPAAGPSSPPPRRTMSKWG
>NC_017030.1|WP_043321541.1|4722760_4724260_+|glucan-biosynthesis-protein
MAWGLGLCVASLACAQQPKAGSVKASGFSAQTVEEKARALAAKPYQEPPIGVPPSFEKLTYDQYRDIRFRDSASLWREEALPFRAQFFHPGFFYTRPVGVNVVEGGKARPVPFSTEQFTYGPLVGTPPKGKVNGFAGFRLNAPLNTKDYYDELVVFLGASYFRALGKGNLYGLSARGLAIDTAQPGGEEFPTFREFWLETPAKGSDTVVVHALMDSPSVTGAYRFAIRPGERTVMDVESTVFARKAVRQLGVAPLTSMFLFGENDRGDFDDFRPEVHDSDGISVWMKNGEKLWRPLKNPKQIQTSSFHTDGLSGFGLLQRDQAFSSYEDLEARSERRPGAWVEPVGDWGAGSVRLVELPTREEIHDNIVAFWVPDAPVQAGAQLRFSYRLSWGFAPEGAKAGGSTVAATRVAAGSKPGARRFVLDFTKASTEGTGPVEAVVTASRGQVLHPRAEVHAVTGGFRAAFELMPDGEGPVELRCFLKRGSETLTETWSYLWIP
>NC_017030.1|WP_014396606.1|4724247_4724763_+|hypothetical-protein
MDSVTTHPFISFAPAMPQEARADTRAALESFFQDFGFTGRNDLEKLAGWVLGTRELSLSPEAALALARWRVEGWLAEVLGPAHVGPSLMVRGRAAFVLVGGARWGADVLMRAPSSLPEAWRRAVCEAVPMSAPAEVPCQMREQVLVLNPFMDMLRRWLRPAAGQAGVSPSR
>NC_017030.1|WP_014396607.1|4724812_4726837_+|glucans-biosynthesis-glucosyltransferase-MdoH
MNAQPYTPALARPRRVMVLGLAALSTGFACVEMHRLLAAHGTTVPELFVLGLFAVCFAWIALSFWSGVAGFIQLVANQRVPGLRWPTEEEAAQPLTRRTAVVMPVYNEDPAAVFAHVQATYESIAATGQLDAFDFYVLSDSTRAESWVAEELAWSELCRRVGGQGRIFYRRRSDNTAKKAGNLAEFCERWGRRYDFLLVLDADSLMAGDSVVKMARLMELNPGAGILQVPPQNVGRSTLFARLQQFAGRVYGPIVAAGAAAWQLGDSNYWGHNAILRMAPFIEHCGLPVLPGQQPFGGHILSHDFVEAALMRRAGYTVWLVPELGGSYEQPPPDLLAYAQRDRRWCQGNLQHLGLVMAGGLHPMSRMHFLMGVMSYVASPLWLIFLVAGLFAALHEWFFAPATLVEFQSTLPGGDAFDTVGALRLMALSLALLWIPRLMGLGLLLANREEATRMGGRFKLVLSVMLEGVVSTLMAPVMMLFQSHFVFGTLFGYKVNWSSQQREDTDLPWSEALRRHKWHMVMGGVLAALTVAVAPGMLAWLSPVIVGLWLAPAISVFTSRASLGLWLQRKGLLLIPEEAEPPAVLVRAQELAEEEMEPVDDALDHVLTDPRAHALHLALLESHPAASVPAALASARRKLLAGGVEPLSPQEKSAVLLDARTLSELRGRRLGVQA
>NC_017030.1|WP_148282570.1|4727011_4728520_+|M20/M25/M40-family-metallo-hydrolase
MEGRDTGSKGYATAAGYVSKELAALGVKPMLKTGFLQPMALQSRRLIEAKSSIALVKDGKALPLVQGEDVVLSSRQGDNGTVEAPLVFVGYGLSIPELGHDDYAGLDLKGKVVVLLQGGPGNIPGPVKSHFSSWEERLKVLKAAGVVGVVYLQNPKLLELPWERMVGANKNPTVVFADPSLNESRGLKVAVVANEAQSQKWLEGAPHTYEELVALANADKPLPKFDLPLRMKAKLAFDVKPLKSMNVVGVMPGTDPVLSKEYVVLSAHLDHVGVGEPVKGDRIYNGAMDNASGVAAVLEVARQLHEQKDKLKRSVVFALVTGEEKGLLGSKYFASRPPVPITSIVADFNLDMFMPHWPFTSVVAHGKDESSLAVPLAEVAAKLDVQVLPDPEPDRNLFVRSDQYSFIREGVPALFFKFGYTPDSEEQKVFKQWLTERYHAPSDDLSQQPVDHEGAARFITFLTALTNAVADAPGRPYWNDDSFFRRFAKPAPKSDQETAPAP
>NC_017030.1|WP_014396609.1|4728532_4731679_-|cyclase
MGEAFRRLTVVAPPADEGASVCAPPPARHLPPTGSVALVFTDIQGSTRLWERCGQAMRDALELHDGVLRALLPGTDGYEVKSQGDAFMVAFASPVEAAHWCLRAQEALLHASWPEALLEEPDAAEEHAPEGLSHRGLRVRMGVHVGEPDCRLDPATHRLDYLGPPVNIAARVAGAGHGGQVLLSGAAWARIQPELASLGMPIARSLGSFRLRGVSDSVALVELLPASLAHRRFGPLRAPRERPGNVPTLRQDLVGRAEELNTLRQWVSEGARLISILGPGGMGKTRLATHFGALESDAGTWEGGVWRCDLEEALTEGDLCHAVGRALGVPLTADGDGSPPAERLGHALAGCGDVLVILDNVEQVVRHVPATLGRWRVLAPCARFLVTTREALRLPGERVLDLAPLGLPDPDETRWDVLLRSDAVRLFVQRARETRGDFMLTDADTPRVADIVRQLDGIALAIELAAARVSVLGVEQLRERLSKRFDLLRVGRRDAPARQATLRGAIDWSWNLLEPAERAALAQCSVFRGGFTLEAAEAVLVLPEGSPDVLEVVHSLRSQSLLCAREVGAPGGFLRLGLYESIREYAALRLREMGDEAACEARHADTYLQVAGRLRERVQKTGGATALRRLALERENLLAACDNAMAVRPATAESLSRALETLVALEPDARTRGPVGLLVERLERALESSAHVAVAPLKRAEALAVLGRAYMDAGQAEYARQALEEARGVFHTLDETTSEKRVLVDLSIVARHAGDGAAAWTLMRDAQALPSGSDRWLEAYAVGNLGLVEQVRRGPEAAIPHLRASLALFREVGDVTFEVGFLTNCAVAIGEAGDDGEAVMLLGEALGRALSVEDRAGQALASINLGCYLMDAGGISEACEHLESAVRLSRLLGQRLLEGTALGELGRASLARGDWKQARAALTEAVTILGRASRWQALRFIAHRAALDAACGDLRAAREGFAGLDGAPELREDPALFQLVDLLRAAVDLAEADAAPPRSAEGNDARAAARRRIEAARNAPRETASSDIRCALRFLEARPGVNEPHLDA
>NC_017030.1|WP_014396610.1|4732043_4732859_+|hypothetical-protein
MRSTSALALMMATLAVGALSACGDDDKKDNTPDSGTNTDAGTSTGNGQCPASAIICEDFEDGETGWKQPDEDHHATIAVDSTRPRSGKASVHVKTDPGYNEDTGSGDQQAIAHLRRDIPAFGTKLYTRAYVYLDRASPEGVMGTYFILFSPKDNDFGGIELQGMHSGAFALDDWSGIKGTGWNHQEGTEVTVSPNKWTCIEWGVERANSSATTGHALVWVDGKLAFDFPNVGIRPFTNFGVGYGFVHPKGDSESETWIDDLAVAPERIGCE
>NC_017030.1|WP_014396611.1|4732863_4733676_+|TIGR02452-family-protein
MSLNRVADETLHILEQGTYVPLSGREVSIRDAVSRAVEGTVLVRPGDFEHLTRPSPVPGFTIEVTPEKTGDAARRLVEQEGEERVLALNFASAVNPGGGFLTGAKAQEEDLARCSALYPCLLKWPEYYDVNRKLRSPLYTDHFLYSPDVPFFRNEHYDLLERPFSVSLLTAPAPNARELPAKDPEVAQKVRDVLFARALKVLQVAAHHGHRTIILGAWGCGAFRNNPHDAAEAFARGLSTMAGAFSRVVFAVYERGGKGPNLSTFRERFG
>NC_017030.1|WP_083892138.1|4733718_4736004_+|carboxypeptidase-regulatory-like-domain-containing-protein
MRWSWVGLLAVVLACAGTPRPVVDTPGPAEDVAWMFRVVDPDGHPVAGARVSVWRADHPPTYNVRSGTTDAQGTGHHLLKPGWYAAEVQARGFVTAFRTDIRLAPESKPALDVSLTRSASLSGRVVDVEGKPVPDVRLRFASSNVAAPFVEATSDAQGQFHFEGAAAGEGLLYVDKWEWSPQRLKMLTPQPELTVVMGRLSSLLVRVVDPEGHLLPMARSYVTPLDGRLGVAYEFKRTPDGLLHQQLPAQRYSVTGHYNPAPGCWWGRSVDVDVLPGQQAEVTVSFEGVATTSPWTGRAVTPDGQPLAGLSLFATSNPSPAGMRTGGFCETTTGPDGRFEWMQALAWPYTLKIRTRDSREQVGEAEQAPSDMKDGPVVFHSPGALVGRVLGPDGKPLTRFDVDWTSNANPEGHFFRRLDASRAYSLIASAPNLAPTRVRVEGRAHEVRTVPDITLDAGHSVVGRVFQEDGRTPVPEAGVELVDPADVDIRRSPSPYELPADMAGRFKFDHVPRRRQYLRVNDKRAGTLLYELGTREDRVDLTLKPDGALVGFVTDGARVPLAGVKVRVRCEAGLDARTETDEAGHYVLRVPADRECFVHVSEEDLRDAPWPRPPPLVFAPQAVSLSPRERERRDFVPRSTGASLRVGFPEPRERLEPFLVPGDARMPKNFAELMALQRSAFSNDPPAFSWRSNDPDLPGYQFLQKNFAFSHLPRKRYTLFVVEPQDTAFAVLRVPVDLTHEETKSLPLRFPLESGGTMLVD
>NC_017030.1|WP_148282293.1|4736050_4738345_+|carboxypeptidase-regulatory-like-domain-containing-protein
MRWSWVGLLAVVLACAEAPRKVQTKTRWPVEEVAFTVRTVDPAGQPVPGVALVARRADQGSLISRSGTSDATGTVRLRVMPGWYVVQAEAPGFVRTLHTDARIPPGEEVRLELTLARAAPFAGRVVDLEGRPVAGAQLRLTPSADEEAALHTESDGDGRFRFDNVPAGAVKLLAEKEEWSPTRLKLAAPQPELTVVMGGLSSLRVQVRRPDGTLSSAASSSIYPEDEKDFFELFPEERSDAKVFQGLRAGRYRVSGRYAPASGDCLWTRAIEVQVLPGQQAEATVSFEGIQDVGPWRGVAVDASGKALAPGQVTAWLADGALDAMGLHGRCDVRSEPDGSFALPHVFKAPVSLEWAAQPTMRWWVSEPLPRGTGEPVTFRPGIGLLKGRILRPDGRPQERFKVHSYSEEDPRGEYDQIVPSSHTYQWLIEAEGFAPALVRGEGREHEILTVPDVVLDVGRTVHGRVVAEDGKTGVPGQQVELVEVFDLETRWRRRPHTVTSGADGHFQFDHVANRGQFLRVDAKAQGTVLRGLEPDEVSVQLRLVPGAELEGFVTEGARVPLAGVNLEVRCEGGFKVDARTDAMGHYSVRVPANRPCFMHAEASLLNVMPRPQPPRVFFSPRRILLAPASHHRLDFEPRHGPAHLRVSVNASREFVTAFVLPGDVPWPGSPGALDDLIRAGFKPEPWSNSWVSEEGDSVFVPSYRSGARFDFRKLPLGRYTLFIREEEQGLDELLRIPVDLSRDGVHAVDSERPARKGGRLYTR

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Crispr_ID: NC_017030_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_15

5282054-5282136

Orphan

Consensus_repeat	Method
AAACCTGTCCGACTGTCCGACAAGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_15

>merge|NC_017030|15|5282054-5282136|CRISPRCasFinder
AAACCTGTCCGACTGTCCGACAAGTTCGCCGGCTCCGGCTCCCGGCGCGACCGTCCCAAACCTGTCCGACTGTCCGACAGGTT

>NC_017030|15|13|5282054-5282136|CRISPRCasFinder
AAACCTGTCCGACTGTCCGACAAGTT	CGCCGGCTCCGGCTCCCGGCGCGACCGTCCC
AAACCTGTCCGACTGTCCGACAGGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014397009.1\|5224506_5225022_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397011.1\|5226518_5227034_+\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051
NC_017030.1\|WP_014397014.1\|5228704_5265490_-\|hybrid-non-ribosomal-peptide-synthetase/type-I-polyketide-synthase	unknown	unknown	gnl\|CDD\|237054
NC_017030.1\|WP_014397006.1\|5221345_5221738_+\|TIGR02266-family-protein	unknown	unknown	gnl\|CDD\|274060
NC_017030.1\|WP_014397023.1\|5311871_5312648_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378964
NC_017030.1\|WP_014397010.1\|5225095_5226481_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237673
NC_017030.1\|WP_014397025.1\|5313595_5314918_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NC_017030.1\|WP_014397021.1\|5308501_5309494_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370782
NC_017030.1\|WP_014397016.1\|5301458_5303702_-\|TIGR02266-family-protein	unknown	unknown	gnl\|CDD\|234715
NC_017030.1\|WP_014397019.1\|5306129_5307683_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NC_017030.1\|WP_014397008.1\|5223079_5224477_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|226082
NC_017030.1\|WP_014397017.1\|5303866_5305324_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NC_017030.1\|WP_014397020.1\|5307695_5308460_-\|phytanoyl-CoA-dioxygenase-family-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397012.1\|5227066_5227537_+\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237999
NC_017030.1\|WP_014397005.1\|5220607_5221270_+\|CoA-transferase-subunit-B	unknown	unknown	gnl\|CDD\|188219
NC_017030.1\|WP_014397007.1\|5221777_5223073_+\|class-I-SAM-dependent-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|225174
NC_017030.1\|WP_014397013.1\|5227843_5228638_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_017030.1\|WP_043321608.1\|5312754_5313570_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293828
NC_017030.1\|WP_014397022.1\|5309578_5311672_-\|S46-family-peptidase	unknown	unknown	gnl\|CDD\|371067
NC_017030.1\|WP_014397018.1\|5305417_5306005_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014397011.1\|5226518_5227034_+\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	1.81976e-80
NC_017030.1\|WP_014397014.1\|5228704_5265490_-\|hybrid-non-ribosomal-peptide-synthetase/type-I-polyketide-synthase	gnl\|CDD\|237054	PRK12316, PRK12316, peptide synthase; Provisional.	0
NC_017030.1\|WP_014397006.1\|5221345_5221738_+\|TIGR02266-family-protein	gnl\|CDD\|274060	TIGR02266, gmx_TIGR02266, Myxococcus xanthus paralogous domain TIGR02266. This domain is related to Type IV pilus assembly protein PilZ (pfam07238). It is found in at least 12 copies in Myxococcus xanthus DK 1622.	1.60423e-27
NC_017030.1\|WP_014397023.1\|5311871_5312648_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378964	pfam12833, HTH_18, Helix-turn-helix domain.	2.16899e-16
NC_017030.1\|WP_014397010.1\|5225095_5226481_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237673	PRK14325, PRK14325, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NC_017030.1\|WP_014397025.1\|5313595_5314918_+\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	9.86812e-124
NC_017030.1\|WP_014397016.1\|5301458_5303702_-\|TIGR02266-family-protein	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_017030.1\|WP_014397019.1\|5306129_5307683_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NC_017030.1\|WP_014397008.1\|5223079_5224477_+\|VWA-domain-containing-protein	gnl\|CDD\|226082	COG3552, CoxE, Protein containing von Willebrand factor type A (vWA) domain [General function prediction only].	1.18754e-26
NC_017030.1\|WP_014397017.1\|5303866_5305324_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NC_017030.1\|WP_014397012.1\|5227066_5227537_+\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	1.39645e-24
NC_017030.1\|WP_014397005.1\|5220607_5221270_+\|CoA-transferase-subunit-B	gnl\|CDD\|188219	TIGR02428, 3-oxoadipate_CoA-transferase_subunit_B, 3-oxoacid CoA-transferase, B subunit. Various members of this family are characterized as the B subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The A subunit represents a different clade in pfam01144.	2.37572e-130
NC_017030.1\|WP_014397007.1\|5221777_5223073_+\|class-I-SAM-dependent-RNA-methyltransferase	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	7.87602e-98
NC_017030.1\|WP_014397013.1\|5227843_5228638_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	4.55784e-42
NC_017030.1\|WP_043321608.1\|5312754_5313570_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293828	cd07742, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.16472e-115
NC_017030.1\|WP_014397022.1\|5309578_5311672_-\|S46-family-peptidase	gnl\|CDD\|371067	pfam10459, Peptidase_S46, Peptidase S46. Dipeptidyl-peptidase 7 (DPP-7) is the best characterized member of this family. It is a serine peptidase that is located on the cell surface and is predicted to have two N-terminal transmembrane domains.	0
NC_017030.1\|WP_014397021.1\|5308501_5309494_-\|hypothetical-protein	gnl\|CDD\|370782	pfam10026, DUF2268, Predicted Zn-dependent protease (DUF2268). This domain, found in various hypothetical bacterial proteins, as well as predicted zinc dependent proteases, has no known function.	0.000131115

>NC_017030.1|WP_014397014.1|5228704_5265490_-|hybrid-non-ribosomal-peptide-synthetase/type-I-polyketide-synthase
MHDFSRTLPGVLLKLGQGPSAHAPLYTFLGDADGEETVWSAFDLDVRARRIAAALRERGAQGERVLLLYPPGLDYIAGFFGCLYAGAVAVPAYPPDPMRLERTLPRLRAIIQDARASVVLTTSGILGLSDFVFEQAPDFRALHWMATDELPEGGERDWVAPEGLGAESLAFLQYTSGSTGTPKGVMLTHGNLLHNLSLIHGAFGARADSVGVIWLPPYHDMGLIGGILEPLYGGFPVTLMSPMAFLKRPMAWLEAVSRFGGTISGGPNFAFDLCVRKSTPEQRRALDLSRWEVAFCGAEPIRPETLERFVEAFGPSGFRREAFYPCYGLAEGTLIVSGGEKSAPPVSVTLSGAALERHRAEEVGAEQPGARTLVGCGQTLAEQRIAIVDPETLERRGPGEVGEIWVSGPSVAQGYWGREEATRETFHARIAREDGGPYLRTGDLGFLRPEGELYVTGRRKDLIILRGRNHYPQDLEATVEGAHPALRPGGGAVFSVEVGGEERAVVVQEIDVRRLGGLREQLAAADTAVGTIRQRLAESHEVQAHAVVLIEPGSLPKTSSGKVQRHACRAAFVAGTLHEVTAWRAQPPGGAGPLSEAPLPSLVAATEASSSVATASSASIAASGASGPLASTGASDSGASASGVSGSGRPGSNTAPGFEASEASSQSAASHDGGAISPSAFGAGSGAREAAHVSKGLPANADEAALIAWLRDVVARHVRMRREEIDVDAPVTRYGLDSLGAVELAHEISIGTTTLTVPMEWLLQGPSITSLARQLISARTAASAPAASSLRRRDVKGDRATSFAQARLWFLDRYAPGDVTYNLPAAVRLEGELDVAALENSLLVLAARHDALRTSFREQDGRPLQVIASFASLPLARVSLESLPADTREAEASRLAHEEARRPFVLTQGPLVRATLLTLDARTHVLVLVMHHAVSDGTSMAVLVRELSAVYAALREGGPSPLRALPVAYADYAEWQREWLDGAALASHLDYWRQQLSGAPRLLELATDRPRPAERGTQGARVPVVLDSRLAEAVRKLAVHEGATPFMVLLAAFQAVLARRSGQDDVSVGTAIAGRDRAELQGLVGFFVNTLVMRTRLSGAPTFRELLGRVRATAMDAYAHQDVPFEKLVEALQPTRERGHTPLFQVMFILQGAQVGAPVLPGLQSRLLDVHSGTAMFDLTLSLSESARGFEGWLEYATDLFNEDTVARIAGHLRVLLEAAVGDPSRQVDALPWLSADESEHLLALSRGPDTEFPSDTTVSSRFAAQVARTPDAVALVAGEGRLTYRELRARARAVAHTLRQRGVGPESVVGLCVDRSVELAVGMLGILEAGAAYLPLDPAYPAQRLAAMWEDSGAKVLVGPRRLEDVLAVPAERRLFLDDVDPSVGADFVRSASDARTLAYVLYTSGSTGRPKGVGVPHRTVMNFFRAMDAHVSPCPGTWLAMTSISFDISVLELLWAWTRGFQVVLAPTGLEPVAFADLLERHAVTHFQCTPSYARALVEEPRALQALGGLRQLLVGGEALPAGLASKLRAHVPALLNMYGPTETTVWSSMHRVETDTAGTVSLGRPLANTGLHVLDDRLRPVPVGVPGELFIGGEGVVRGYLGRPDLTAERFVPDAFREAPGTRMYRTGDRVRWLADGTLEFLGRIDHQVKLRGFRIEPGEIEAALRTHPEVREAVVDVRDQRLVAYFVPATLEAGVLREHLRSRLPAYMVPTAFVGLDALPLTPNGKVDRGALPAPTAPAVAEDTGPLTPLQEKLAELFQDVLHVERVGAHDDFFALGGHSLLATQLVTRVSARFGVDLPVRAVFDAPTVARLAERIEALPSRYPAAPIPKVSRDEGLPLSFAQQRMWFLERLEPGQALYNIPLALRLSGPLDVEVLRRTFAELVRRHEPLRTTFEEHEGQPLQRIHAPPSDWSLPVESLPEGAERDTTLQQRMREDATRPFNLGTGPLLRTRLLRLSPDEHMLLLCMHHIVTDGWSMGVLVHEVGSLYPALAAGRPSPLPALEVQAADFAAWQREQEDSETARARLDTLKESLKDVPVLTLPAEQGQPGARSTRGGSHVFTLPASLVRSLEQVGRDRDATLFMVLMAGYQAVLSRYSGQDDFAVGTPVAHRTRPELEPLIGVFLNTLVLRARLDGAPRFSELLDRVRESSLAAYAHQDVPYERLVEAVAQARGGDRASLFQVMFVLQNAPLSTPALPGVRVERLHTSTETARFDLHLSLTASGGGLEGTLEYSRDLFSEDAAARFATHFQVLLEAVARDAATPVHLLPLMGDAEQRLLAAWNATERDYPLEGTLHGLVEAQVARTPDAIAVDFEGARLTYRELDGRANQLARALRARGVGPEVRVGVCAERSLELVIALLGVLKAGGAYVPIDPSAPAERRTYQVEDSAVAVVLTQQHLRPLLSVGSTPVLCLDADWPQVASLSPEPEESGVGAEHLAYVIYTSGSTGRPKGAMNTHAGIRNRLLWMQDAYRLEPRDVVLQKTPFSFDVSVWEFFWPLMTGARLVVARPGGHQDAAYLVDVMAREGITTVHFVPSMLQVFLEEPGLERCTALRRVVCSGEALPLELKDRCLDRLGVPLYNLYGPTEAAVDVTAWTCERHDGRRSVPIGRPVANTRIHILDAALQPVPVGIAGELHIGGVQVGRGYLGRPALTAERFIPDPYGPPGARLYRTGDRARVLADGTIEYLGRLDFQVKLRGFRIELGEVESALRQCEGVRDTVVVVREDAPGDKRLVAYVVGRGVTAEALREALKAKLPEYMVPSAFAVLDALPLSPNGKVDRKALPVPDVHAVAVVPSKPQRMTPFQQRIADLFRDVLRVPKVSVHDDFFALGGHSLLATRLLSRVRSTFQVELPLRGLFDGATVAEVTEQVEAQLLSRTDLPRVPAIRKVPRDGGQVLSFAQQRLWVMEQLQPGATPYVLLGAVRLDGALDVEALRRALEFLVERHEALRTTLAMKGRDPVQDIHPTPLWALPVTDLGDLTDPESAVQRLAREEAGRPFDLGTGPLLRTRLLRLTSTQHVLLLGMHHVVSDGWSLGVMVREVATAYAAFASGKAPVLPELPVQYADFAAWQRGWLQGDVLADEVTWWKEQLAGAPRVLELPTDKPRPTTRSPHGALMPVHVPRDLTDRLTGLARREGATPFMALLTAWQAVLSRYSRQEDLLVGAPIAGRTHGDVEGLVGFFVNTLVLRARIHPEASFRTLLGQVRDTTLAAYEHQDLPFEKLVEELQVPRDLGRTPLVQAVFALQNAPAEAFDAPGLRMEPLEVDAGTAHFDLSLLLTETPDGLRGSIEYSTDLFERDTVARLAGHLRVLLEAAVAGPDVPLSRLPWLTPEERQQVLVAWNDTALPYPSDGTLAERFALQASLRPDAIAVEDGDEQLTYAQLDARANQLAHVLRARGVGPDVRVALCLERSVGFVVTVLGIVKAGGAYVPLDASYPAQRLSFMLEDARPHLLVTTRELRGRLHLPDESLPCLFLEELSLAGEPVTAPQTGVGPRNLAYVIFTSGSGGRPKGVGVEHRGLLRVLHAAPYLHYGTRDTVLLFAPVSFDGSVLELWMPLVHGSRLVVFPGHVPAGDMDTLARVVERHGVTFIHLPSGLFSQLMEHRPDILGRLRELHAGGDIVSAPHVRRAVESLGIPFTNGYGPSECSIVATTFTAERPDQVGTSVSIGAPLANTSVYVLDARLNPVPVGVPGELFLGGDGVGRGYVSRPDLTAERFVPDAYGTTPGARLYRTGDMGRWRADGTLEFLGRIDTQVKVRGFRIELAEVEAALRDLTAVQDAAVVVREDVPGDKRLVAYAMPGPGHVLEASALRAALRQRLPEYMVPSVFVMLDTLPLNPSGKVDRKALPAPDAASTGRQGRFVEPTHPLEQRLAPVFARELGTDRVSAQDQFFEDLGATSLSVVRLAARLREELQREVPVVWLFEHPTLEGFVQRLERESQGPGTAPPPVSQAPGHRPREAPKAGASGSIAIIGMAGRFPGAMTVAEFWRNLRGGVESITRFSPEELEHLSLLPEGLELWHQPAFVPAAGVIDGADRFDHAFFDMSLREAQFTDPQQRLFLQTAWAALEDAGIDPDRFPGAISLYAGATGSGYTDAVRQAMPLDAASYMELHGTATHESLATKASFKLGLTGESVLLYTACSTGLVAVHLAAQSLRTGQSDVALAGAMRLSLPQRTGYVHEEGLIFSPDGHCRAFDAKAGGTLSGNGVGSVVLKRLEDAVRDGDAIYAVIRGSALNNDGRNKSGFTAPSVQGQAAVVSQALANAGVAPEAVGYVETHGTATPLGDPIEVAALTRAYGLGAEHRGSIALASLKTNVGHLDTVAGLAGLMKAALSLHHGEIPPSLHFEKPNPQIDFDAGPFFVNTTLRPWPRGETPRFAAVSSFGIGGTNAHAVLEEAPLRRSGATSRSHQLVLLSARSLEALQAAARQLDAHMAEDVDAQALADLAFTHAVGRKAFEYRHALVVKDAADLVWQLRKPVVAVKTEKRAPRVAFVFSGQGAQRVAMGRELAEASPRFRAHLDACLALLEAPLRERVSWLLSPQAGAEAEATAALADTRVALPALFSVQVSLARLWQDLGVTPYAVLGHSFGEYAAACVAGVLSLEDAMRLTVARGELMHRMPPGAMLAVALPVDRVQPLLSGRLELAAVNTPDRCVVSGPVEDVERLEAQLKAQKAGAVRMPAPHAFHSVDVEPLMPELARVVGTLRRSEPAVRYVSSLTGMVAQPGQLADPRYWTEQMRKPVHFTRAVETLQEEGCAVLLEVGPGQDVTPLVRANLMGVESGAPRVRGLPSLRLGGKTTEQMGWLQTVGELWTAGVPVDWSAFYAHEQRLRLHLPTYVFQEKTVWVEQKAQGRVTVKAVEAAALPASIASEVARPAPVVASAILEASPEAPSAPSQPARDDAPRGEVEERVAALWRARLGLEFVGRHDDFLEIGGNSLTAAQLLNQVRDAFGVNLPLAALFEAPTVAGIAERLVPLLHQAPQAAVSAELPLVPLARTGELPLSFVQERVWRLEQHLPGQSAYNIPFVLRLEGDLNADVMERGIQEIVQRHEALRTTYDAVDGRPVQRFHAHMRVPLTRVELSGPMEDREPEALRLAREDAAEPYDLVHGPVLRTTLVRVDTRLHLLLCGIHHIVSDTLSITLFVHELGQLYDAFLQGRPSPLPPLPVQYADFGAWQRHSIAGGHLPEQDQGWRQRLAGMPRKLDLPTDRPRPTASPLTSERMTVEFPPTLAHELVAFARREGFTGYMTVLAAWQTLLHRYSGQTDVIVGTPIANRTRPELLPLIGYVAHSAAFRTRFTDGLTFRELLAQVRDEVADAQTRPDVPFEYLVEALIPGHDIGRGRLTDSVFVYHTGAAAGAGTLNLTGLRGSLVEVPGTPVQWGATLADLTLLLSEAPGRVHGVLEYATELFDAATVERLMEHFQVLLGAALARPETPVAQLPLITEAERRAWPAPRASPGFTSVPALLAERRARHADTTAVSRGDAHWTWAELGARADALAARLKSLGVTAGTPVAVCLRSSPEKLAALWGVLAAGGAGIALGPADLTQLPVYAPEGTRVPVLVTTRALVASVRVEASRVVYVEDVDASGVPLRAGVDAHALAWLLPTGSGQPAWALGHRELSEFFTGLDARLSPPDGGAWLSASEASAERPELEALWALTRGLRVVYPPERITARLVSLGGGGPRAKAMDLSLIYFANDEDSLQGPKYELLMEGAKFADANGFSAVWTPERHFHSFGGLYPQPAVISAAVAAVTKHLHVRSGSVVLPLHDPLIIAEQWSVVDNVSQGRVGLSVATGWHTQDFTFAPANFEKRRDILLEKLATLRALWRGERFKRPGGAGTMVEGALRPKPVQKELPVWLTATSNPETFRMAGELGAGVLTGLLSHSLEELKPKVALYREAWRRNGHPGRGHITCMLHTYLGDDDQEVLRLVRKPLLAYFRSSVDILTSLLLTQGYQGDIQKLSPEDIDALLEHTFENHAKTTGLVGTVDGAVKRLRDVRAADVDEVAALIDFGLDTPVVLEGLRRLAVVRERMDAEAAARQEQVLVEAEAGVEGLLELARQSGAVLLHTSARLARSLSELPGARESLARVGALVLEGASVELGAALHRAAGVEVWLSGDAQEGALLPRTLGERIPANLQAWVLDAAGQPVPAGVVGELALAGAGLPTALWRASDDDRRLVPHPREAAARLYRTGRHARLRADGRVEPVASPSRLPPPPVARPAVMEAPRPTVAPVAARPAAPVVNEGPPPIPRVGRDRPLPLSFAQQRLWYLQQLEPGSGAYNNPSLFRLVGELDVDALQAALDALVARHEVLRTTYALEGDRAVQKIHPPRGLPLPRRDVEGDTPEAREAEMQRFCRAYALLPFDLEQSVLRATLLRLDPQVHVLAIVFHHAVSDAWCNMVVAHELTANYAAFHSGQPSPLTELPVQYADYAVWQRAWLEGGVMEAQLGWWKQQLAGAPVLELPTDRPRPALQSFEGARYRFAFPADVSAPLLALGRRNGATSFMVMMALFQTLLSRYSGQDDFVVGTPIAGRTRPEVEWLLGCFINTLPFRSKLSGQPSFVELLGRVRTQALEAYARQDAPFERVLETLELPRDLSRTPVFQAVLNVINTPEAKGQLPSLALSQVEVPTDTAKFDLSLEVLESRTGIACHLEYATALFDAATVERMAEHLVVLAREIIAAPEAPLAKLSLLTPAAREQVLRGWNDTHVDFPPGATLHHLFESQAERTPDAFAIQFEDQRLTYAQLEARANQLAHHLRAHGAGPETLVGVCMERSLEMVVALLGVLKSGAAYVPLDPATPAERLAGMLEDTGAPVLLVQERFRAAVPPRTAHVIALDTQWEAIAREPTVRSRPLAGEDSLAYVIFTSGSTGRPKGAMNAHAGVVNRLRWMQGRYGLTPSDTVLQKTPFSFDVSVWEFFWPLMTGARLVLARPGGHQEPDYLVALMAREGVTTTHFVPSMLRAFVEEPGLESLPRLRQLMCSGEALPADLVLRAQARLPHTTLHNLYGPTEAAVDVTSWECPRDEALRVVPIGRPVANTRMHVLDAHGQPVPVGIPGELFIGGVQVGRGYWRRPALTAERFIPDAFSDTPGARLYRTGDIARWRTDGTLEYLGRADFQVKLRGFRIELGDIEAALLTHPDVREAVAVVREDAPGVRRLVAYVVSGADLELASLRTLLSRRLPEYMVPAIFIPLPALPLTSSGKVDRKALPTPEVQRAATREYAAPRTATERTLSEVLAQVLRVERVGLDDNFFELGGDSIISIQAVARARQAGIQLSVRDLFQHPTLAALASVARVSGVRLAEQGPVVGEVPLTPIQRQLLERDPTHAHHFNQVLLLQVRQPLKAAWVEEALQTLVVHHDALRMRFVREDGGAWRQQNAAPDEARVSLLQIDLSELPEDMRSARLEEEAERLQASFDLSRPPLLRAALFHFGAGQEQRLLLILHHLVVDGVSLRVLVEDLETTYLRLRTGQSPALPAKTTSFLAWARRLEAHALSDALHAQTALWLDEARRNVAPLPTDGSGPGTEGSHRTMSVRLEAEQTRLLLEETPEAWRARINDILLTALALALREWTGQSRLLIDLEGHGREALFADADVSRTVGAFTSLAPALLQLPEGGSAGDCLRAVRDSLSAWPDRGIGYGLLRFMGPAELRQRLATLPSAQVLFNGLSQRDGSIGASTLFAPGTEPTSMAVSPKALHAYALSVGGFVVDGQLRMDFGFSHEWHHAATIEALAQGFTRALRELIALRHSEDARRRTPSDFPLARLTQASLDAVLAAQGPTVEDLFPLSALQEGMLFHALNDPEAGFYFEQTAWSVHSDVDLALFQRTWQTAVDRNPILRTAFVWKDLEAPLQAVHSRAVLPFEAHDWRHLPELEQQALLEQLYAEDRARGFDVSRAPLSRMTAVRLGDARWRFVWSHHHLLFDGWSLGLFFQEVFAIYDALTAGTPLPAAGRPPFRDYIAWLGQRDVAEDERFWRGQLGGLSSPTPLPAMRPSSAHPDGTVNQPNLVLTLPEDRTTALEGFARQHRLTVNTLTQAAWALVLARHADTRDVLFGTTFAGRPPELAGSEAMLGLLISTLPVRVAIPDEDASVLAWLQSLQAKLLDIQQHQHTPLVAAHGWSDIPRGLPLFQSLLVFENVPLDESVLRRSTALDLRDFVIGESTNYPLSATVYPGRELQLHLAYDENRFDADAVQRVLGQWSQALESLIQPGARLADVSLLPAEDRAWLLRTGTGDVVDFERDTTVHARFERQAAATPDADALVFEETTLSFQQLNARANQLAWHLRSLGVGPEVTVGLCLERSAEAIVALLAVLKAGGAFVPLDPKAPAARKSFVLKDSGASVLVTTQALQEAWHPEVPHLVRLDEKPVGQSDRFSDNLPPAAGPANLAYVIYTSGSTGAPKGVMVQHRSVIHLHLAMTRSIYEELAPAQRITVNAPLYFDAAIEQVIQLLDGHCLVIVPEDVRLDPEAMLDWMERQRIHLLDGTPSQIKLLLSAGMLERAHGPVRFSIGGEAMDEVTWRQLAAAKHARAYNGYGPTEVTVDATTIAVQGATQPLPVIGRPITNLRAYVLDANLRLAPIGTPGELCLSGEGVTRGYLGQPALTAERFLPDPFSTEPGARMYRTGDKARWREDGTLDFMGRLDFQVKLRGNRIELGEIEATLRAHPGIRDAVAQVHDDRLVAYVAPPVDTSPLREHLLRHLPEYMVPAVFITLDVLPLTPNGKVDRKALPAPAAAPATERVIEPPATPTEAALIPLWIEVLRVPAVGRHDGFFELGGHSLLATQLVSRVRKHFGVELPLRALLEGPTVAALAERIDALRQPASESQEAPASALPSLTRVERPDVLPLSFAQQRLWFIEQLGTVGNAYSLPSMLELEGTLDIIVMLAAFDELVRRHEALRTTFRSHEGTPSQVIHPPFPMPLRNVDLSALPTAEAREAEASRLALEEARTPFDLEQGPLFRGLLMKLGPTKHRLLLNTHHIISDGWSTGVLVREMGALYTAFSAEESSPLPELPVQAADHALWQRDWLQGDVLESQVAYWRGQLEGAAPYLELPTDHPRPARQSFRAGVQPMTLPRELSEALESLAKQTHTTPFMVLLAAFQLLLHRYAGQEDVLVGSPIAGRRHAESEDLIGYFANTVVLRTRVRDTLRFRELLEQVRATTLGAYEHQDLPFEKLVEVLHPERDLGRTPLFQVTFTLQNAPLPELSLPGLTLRPLESTPDVILFDLQWLMMRTPDGFDGGLVFNQDLFEPATAAGMAEHLRVLLEAAVRAPDTRLGQLPWLTDAERRRLLIGWNDTARDYPRDASVGALFAEQASRTPDAIALKSGGETLTYAALERASNQLAHHLRRQGVRPGHRVGLCVERSFDLVTGLLGILKAGAAYVPVDAKTPAERITWMLQAASVSVLVTQEALADELPQVTDLQVLLDADEAQIARQPETPLDLNVSAEALAYVMFTSGSTGRPKGVSVPHRGITRLVRGADFIHFGPEEVFLQLAPIAFDASTLEIWGALLNGATLVLAPPKALSLEETGALLRREGITTLWLTAALFEQMVLHQGDALARVKQVLAGGDVLPVERVREHLKRLPPGAVLVNGYGPTENTTFSATHTLRAGDTVGRSVPIGRPLSNSTAWVLDASLQPVPPGVPGTLYVGGDGLAWGYLQRPDLTAERFIPHPFATEPGARLYDTGDRVRWQRDGTLEFLGRTDFQVKLRGFRVEPGEIEAVLRQSPEVEEAVVVVREDVPGDKRLVAYVVSEGLDTAALRASVQKQLPDYMVPSAIVALPKLPLSANGKVDRKALPAPQARGTDSATSAPRSELEKALAGIWAEVLHLDTVDIHGDFFELGGHSLLATQVVSRIRSTLGVELPLGELFRAPTVASLAERLVNARRTQAPPLVRAERTSAPPLSFAQQRLWFVDQLEPGSPLYNMPLALSLTGDLDVEALRASLDALMARHESLRTTFRMEVGKPVQDIHPEGHVPLELADLRGLGSRAAKQAEAQRLGHAETLRPFDLTRGPVIRALLMKLEEREHVLVLHLHHIVSDGWSLGILVRELTALYEARRAGRSAALPELPVQYADYAVWQRGWLQGGVLQAQVEWWKNQLSGAPFVLDVPTDRPRTATSTQRGGLVRLTLPRVLSERVDALAQAEGATPFMALLAAFQAVLSRVSGQDDVLVGSPIANRRHAETEGLIGFFVNMLVLRGRFSAKTTFRELLAQVRATTLGAYEHQDIPFEHLVEALQPERDLGRTPLFQAMFALQNAPVTELAVPGLTVGPASFDGGSPTQFELALDLNRTRDGYEGRFHYAAEWYDAGTIERFAAHLRRLLEAVCDAPDLPLADVSLVSPEELVRLVRMGGGELLDFERDATLHGLIERQVARTPDAPAVVFGETALTYRQLDTRANQLAWRLRSMGVGPEVRVALCLERSVESIVAILAVLKAGGAFVPLDPGAPPARRDFVLKDSAAAVLVTTETACGDWSPYGVQEVWLDVEQAGLGALSHEPLPTLTGPEHLAYVLYTSGSTGKPKGVMVQHRSVLNMHRAMGRAFYAGQPRGQRISVNAPLYFDAVIERVVHLIDGHCLHVVPDALRLDPEAMLAWLEHHRIDALDCTPAQLKPLLAAGLLERAWVPPVILTGGDALDVETWRRLAATDRTRAFNGYGPTECTVGTTGAPIQGSPRTEPVIGRPLANLNAYVLDTRQRLVPFGMPGELCFSGESVTRGYLGRPDLTAERFVPDPFSAEPGARLYRTGDKGRWRPDGTLEFMGRLDFQVKLRGYRIELGEIEATLRTHAGVRDAVALVREDTPGDARLVAYVVTDGDTEVLREHLRRHLPEYMVPSAFVTLPSLPLTPNGKVDRKALPSPEAQWRAARSYEAPATPAEVALASLWEELLNVPVVGRNDHFFELGGHSLLATQLVSRIRARFGVDVGVRALFESPTVAALAQRLPDAPEASALPPLRPATNPGPHPLSFAQQRLWFIDQLDPGSALYNMPTALRLSGAVDVPALQQAFDALVERHEALRTTFESHNGEPRQHVHPAPTGVLSVVDLTGMPEDAKEAEAVRLASEDALTPFDLATGPLARLTLLKLGEQEHVLLLCLHHAIGDGWSMGILVREVTALYEAFRQGQPSPLAPLPVQYPDFAVWQRGWLQGEVLDAQLAWWTQQLAGAPQALALPTDKPRPPHRSARGATFPVRLSQSLSESVEALAQAEGATPFMVLLAAFQTLLHRYSGQEDLLVGTSIAGRRHAETEGLIGFFVNTLVLRARFDGRPSFRKLLAQVRTTTLGAYEHQDIPFERLVEAVQPTRDLSRTPLIQALFALQNMPDAEVRLPELTLRPVEVDLPTTKFDLDLTLARTERGFEGDLSYATDLFEPATARRLSEHLVQLLEGATAKPDAALDSLPLLTAEERQWVLEEWSGETALFDADLPFHVRFEHQVTRTPKAPAVVMGDTTVSFHQLNVRANQLAHYLRSLGVGPDVPVAFCLERSPEAIVALLGILKAGGAYVPLDPAAPEARRAFILENSGAAVLLTTQAQMEAWQPAVRHVVRLDADARRIEASSPANPRVATRPEHLAYVIYTSGSTGMPKGVMIQHRSLAHLHRSLTEACYTQAPKVMRVSLNGPLYFDASVTQLLLMADGHCLCIVPEAVRQDPEAMLAWLEQRRIDALDCTPSLFKLLLEAGFLEQAHVPSICFIGGEAMDEVTWRTLAATHRTRAYNAYGPTEGTVASTTECIQSTAQPTPVIGRPMLNVGVYVLDANLNPVSVGVPGELFIAGEGLARGYRNRPDLTAERFIPHPFSTERGARLYRTGDRVRWKQDGTLDFMGRVDFQVKLRGYRIEPGEIEAALRTHPGIRDAMVLVREDVPGVQRLVAYVAPEVDTAPLRSHLQRSLPDYMVPAAYVALPVLPLTPNGKVDRAALPAPVDEATNPEARVGPRDEQEAMLERLWAEALGVAAVDVRTSFFELGGHSLLAVRLMAAVQRETGRKLPLSALFQAPSVERFAVLLGEAEPEDPEPFTALVPFTNQGTGTPFFCVHPVGGNVLAYAELARRLGPDQPFYGLQARGMDGTDQPLDTVEALAASYVREVRKVQPHGPYRLGGWSLGGVIAYEMAYQLREAGEAVELVAMIDSYVPETVPDSEPNLDRTLAVALFAQDLMGVSLADLDVDTAELEPEAVLTKVLEAAAQAGALPSGVDTTALFQVFEANLEAARRYHPPAMDQHVLRIHAEERDETRTPDGGWAALVGEQLESHELPGTHHTLLREPTVQAVAELLAKALRDAGKE
>NC_017030.1|WP_014397013.1|5227843_5228638_+|DedA-family-protein
MEELLTNLLGSSQGLFAYLSVFAILVACGLGVPLPEDISLILGGFLAHKGAANLPVMMAVGFFGILVGDSLIYLAGRRLGTKLGRDPGAKGGGFFSKIVTPEKRAKVESLFVTHGQKIVMIARFMPGVRAVTYFTAGSVHMSYWRFIFWDGLAALLSAPVFVWLGFHFGGELDMVIRKLKDGQVVVLGSLAVLAVGYFLYRRRKNAKLKAEAAAHAQVTPVALPPVPETLENSMSPTRAASPSAFFDVPADKAPPSEPDLNAHK
>NC_017030.1|WP_014397012.1|5227066_5227537_+|cyclic-nucleotide-binding-domain-containing-protein
MALAPETTLKACPLFKGFTDTGISIFAAAAVSRAYPKGTALFTEGKAGDSLLIVGEGTVRLSARSPSGEDVPLGEVTAGEPLGELALVQKGERLCSATAQTDVLALEIRAADFQKLLAQKPQACIKLLMGIVSHFGAKARDNRDMLRTLVARAPGS
>NC_017030.1|WP_014397011.1|5226518_5227034_+|gamma-carbonic-anhydrase-family-protein
MPLKPFRGVSPRVHPSCFIEDSAQVVGDVELGEDSSIWFNSVLRGDVNSIRIGKRTNIQDLTMIHVTSQGDSTTVGDDCTVGHRVILHGCVVGNRVLVGMGAILMDGVEVGDDCIIGAGTLLTPGTKIPPGSLVVGSPGKVKRPIHDGEREFLVQSALHYVHTAAEHRASR
>NC_017030.1|WP_014397010.1|5225095_5226481_+|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MKRYFIHTFGCQMNVNDSLRMSEALSKMSYVPTPEPDNADLIILNTCSIREKAEDKMLSALGRYRAVKASRGAILGVGGCVAQQEKDKLLKKVPYLDFVFGPDNIAKLPEVIARVQDARERVVETAFVDSEEYVFPRADAETSRGKVTEFVTVMKGCDNVCSFCIVPHTRGREVSRNFPDVLTEVADLAGVGLREVTLIGQNVNSYQGGISFAQLLLRTAEVPGIERVRFTTSHPHDLSDELIEAFRVQPKIAPHFHLPVQCGSDRILKMMRRDYTVEQYMERLEKLRAARPGIAITTDIIVGFPGETEEEFEMTMQLTERVKYDNQFSFVYSPRPKTGAALREKDWGPIPHEVKVARLERLQKLQRRISGEYTQAQVGLDVEVLVEGRSRYDATKRFGRTPENRTVNFEGDAPAGSIVKVHVERATPNQLAGKQVAVLQAPTVAPPAVELPVPLHVPAEA
>NC_017030.1|WP_014397009.1|5224506_5225022_+|hypothetical-protein
MAPSFFDDYQDVPNVETGPAFDAADDRTLRMASRPVDKALLDQLVRYQETFLSHVEADASPEAMAGAAKAALETSGLDVKAAEWGSAVLRAFGGRRWTVQRLRSKLTELESRSGPEVDEVKKRVQDELVKQERETDALGRRYGVETVALLREREAELVALHTRLTKVLSRG
>NC_017030.1|WP_014397008.1|5223079_5224477_+|VWA-domain-containing-protein
MDARIVEFAEVLRQNGVRVSTSEVQDALRATAEVGLEDRALFRSVLRTTLVKRELDVETFRRAFDFFFSGAACTFEAIDKSLAKQLEEEGYLEGDLLKMVIYQMNLLAPEMSPLAQAILAGDRARLAQIFRQASLQLDLGQLESPLQTGFFTRRMLAGAGMERARSDLKSMEDELKARGLHAEGVEIVSRHVAAAMRKIEEAARAEVKRQSEARIRRRTDTVTEKPLHLLTQAEVDQMEAAVRTLAEKLKSRMIRKQRSHRRGSLHAQRTLRRNMPWDGIPMVPVFRTRRPERPELVVLCDVSDSVRNASRMMLLFMHTLQSLFVRVRSFVFVSDVGEVTQFFKDLDVSEAIDAATAGRTVSMSSNSNYGRALADFTRDHLGSITRRTTVMIIGDGRNNYNASNAWALKDLKRKARRVLWICPEDRGNWGIGDSEMLTYEKHCTQAVVVTSVSDLARIAEQLVPV
>NC_017030.1|WP_014397007.1|5221777_5223073_+|class-I-SAM-dependent-RNA-methyltransferase
MTTLPESPIELTIERLGQLGEGVAQWEGRTVFVPGAFPGDTVRVRLEAQGKVLRGLLGQVLTDGAERVPSRCVYSDACGGCDWLELSVPAQRSAKQEIVLSTLEHLGHLKRSDFTVRPLMVAPRDWGYRRRAVLHGAGKGALGYFGRRTHERIPVDVCPALTPVLTALPGKLAPLLKPLAKDTEEVLLLAEGDKAAFAVNMSGPVTARHLEAAEAAVRALRLEGAVLVPKEGSARLIGRPVLRSLSPLRPEVPVYLRPDAFAQAHAEANVGLVTAALYELGAKETDSVLELYSGNGNFTFPLAGTAGSVLGVESSPVGVELAQRSAREGGVANVRFVQGDARKVCDGLVAEGRSFDLCLADPPRAGAPGLAKWMRALNVRRVVYVACDPASLARDAAGLVEAGYKPVALQVVDMFPQTHHVEAVMSFERGA
>NC_017030.1|WP_014397006.1|5221345_5221738_+|TIGR02266-family-protein
MSDTSEKPVPAPRAHRIDHELPVAYRTVSGFVTDWAVNLSRGGLYINTPQPLPVGTVVRLLVSLPGASFPVDLSGKVTRTNPQGTPGSEVPGMAVEFLDVDDEKRSRIEAFVERLREALPADERGSATRK
>NC_017030.1|WP_014397005.1|5220607_5221270_+|CoA-transferase-subunit-B
MPLTREQIAQRIAQELKDGFYVNLGIGIPTLVPNYIPHGVEVVLQSENGLLGIGPYPEEGSEDPDLINAGKETVTVVKGSAFFDSALSFGMIRGGHIDLAVLGAMEVSEEGDLANWMIPGKMVKGMGGAMDLAVGAKRIYVAMEHANKDGQPKILKKCSLPLTGLKCVHHIVTDHAFIDVTPEGLVLRELAPGLTVERVQQLTEPKLKIAPDLREMKFQA
>NC_017030.1|WP_014397016.1|5301458_5303702_-|TIGR02266-family-protein
MAELNQAGAVGLVVKLPFATPEEFLAKYGGNITRGGIYLRAKAVRPPGTAVTLDLRLASGDRLLYTAAIVHFVTGQQGQGISGMGLKFGEADPPTRRFLESAVAILPHAQSDVPPVPNGVGPADFTVPAPAAAPALPPAVAADPGGPARMDAPAAAPSPALEMVTDASLGLSIEEPPRTGPVIGIDLGTTNSCAAFVRGNKPGVLPSREGHNTVPSILAFNQRGKLVVGHPAKGQMLTNPRQTVYGAKRLVGRPYASPIVGQIKGRFHYEIAAGQNGEAAVRLGDRIYSLQQISALILREVREVAQNQLGQPISRAVITVPAYYNDNQRHAVREAGKLAGLYVERILNEPTAAALAYGYGKKLNQRVLVYDLGGGTFDASVLELHDTVYEVISTGGDTFLGGIDFDNAIVEYLLQEFERQTGRAFQGDRVALQRINDAAERAKCALSERSEMRVHVAFITMIDNKPYDLDVTLTRQKLIALTEGLVDRTVQVCEEVLQAKGLKPTDIDEVILVGGQSRFPLVHEKITKFFGRPPSKGVHPDEAVALGAALLAHSLGQLEGVVLIDVLPMAIGVGLPGGRFKPVLERNVSLPAAKSYTLSTHRDGQTELELTVFQGDSERAQDNEYLGTLRLAGLPKKPRGAVQVSVTFEVNNESLLKVTAKEGTTGREVVSTFTTRDTPEAVKARLAQEESAAAAPAPPVVTPGTAAPAARKVAASAPVVQEAEPDVAVVSKQKGFMGWLKGLFGRA
>NC_017030.1|WP_014397017.1|5303866_5305324_+|IMP-dehydrogenase
MLNPDIRLALTFDDVLLLPGESAVTPRDADLTTRLTRNIRLNVPLLSAAMDTVTEARTAIAMAQEGGIGVIHKNMTPEQQALEVLKVKKFESGMVVDPITIDPKAPLARALELMKVHGVSGVPVVQGKRLVGILTSRDVRFEKNLSQKVEDVMTTKLITGREGITQDDATKLLHEHRIEKLLVVNEAYELKGLITIKDIEKRRTHPYAAKDAKGRLLCAAAVGVSPDREARIDALVKAGVDVIVVDTAHGHSKGVIEGVRDTRKNFKGFDLIAGNVATAEGTRALIEAGVDAVKVGIGPGSICTTRVVAGVGVPQVTAVDDCAREADKHGVPIISDGGIKYSGDIVKALAAGASSVMIGSLFAGTEEAPGDVILYQGRSYKSYRGMGSLGAMKQGAKDRYFQSDVEAVKLVPEGIEGRVPYKGTLSMNVHQMLGGIRSGMGYVGCATIEELRTKATFTRITSAGLKESHVHDVIITEEAPNYRME
>NC_017030.1|WP_014397018.1|5305417_5306005_-|hypothetical-protein
MLLLSASGCVKEITSDERLERDTRSVAVKDAPGVSELSKLTCDDTSAPLNKARDVNRPESDRLVDYVNLYSSLKDRTHTFEEAMARNPDLSYREGSQSLVNAKDACIQQTADVRVEFETYLRELVAVPTVQEIKGGNTVTVARLDFSTLRKAIETLDPDDRESLLQSVNSAEKRVSATAAPAEDTSTGSGKRRGK
>NC_017030.1|WP_014397019.1|5306129_5307683_+|glutamine-hydrolyzing-GMP-synthase
MDLHSEKILILDFGSQYTQLIARRVRELGVYCEIHRPDLPAADIQQFAPKGIILSGGPASVEAPGSPRCDPFVFEAGVPVLGICYGLQLISKLLGGRIDRSAHREFGSAAVEVLAARGPFAEFRPGDQVQVWMSHGDRVDELPPGFEAIGRSGNSPFAAAAHKTNPWYGFQFHPEVVHTPQGKAMLRAFLFNDCKVSGSWTMKGFIDEAVETIRKQVGDEGRVICGLSGGVDSSVAALLLHRAIGPRLQCIFVDNGVLRQGERAQVEALFVDRFHVPLKTVDARERFLSKLAGVTDPEQKRKIIGREFIAVFEEASRDVQDAGFLAQGTLYPDVIESVSWKGPSVTIKSHHNVGGLPEQMKLKLVEPLRELFKDEVRALGRELGLPDEMVSRQPFPGPGLAIRVLGEVNEKRLDLVRRADAIVQEEIHKAGLYKEVWQAFAVLLPVQSVGVMGDERTYESTCVLRAVTSVDGMTADWARLPFPILEKISSRITNEVRGINRVVYDISSKPPATIEWE
>NC_017030.1|WP_014397020.1|5307695_5308460_-|phytanoyl-CoA-dioxygenase-family-protein
MDARAEQFMRDGFLRIDGAFPREVADEARAILWRDTGCDPDQPSTWTRPVIRLGMYTQKPFVDAANTPVLHAAYDELVGAGRWLPLGAMGTFPVRFPSPTDPGDAGWHIDVGFDFDKPDFMDWRANVASKGRALLMLFLFSDVGEDDAPTRIRVGSHQDIARLLGPAGEAGLTLRQLAANGFAESAHRREVLATGEAGTVYLCHPFLVHSAQPHRGARPRFMAQPPLLPREPLSLARLPEDTSPVEEAIRRAVT
>NC_017030.1|WP_014397021.1|5308501_5309494_-|hypothetical-protein
MFPRPALLAATTTAALALTACAARQPVEAAPAAIQDVVSTVDVDHFWEAYDAVRATTDPAEQLARFQALYVDRGTPGLHSFMRARRYTAQGYVDAIRDYPRFWASVRPLTARAREAVARVAPTLERFRALYPRLGTAEVYFTVGALNSSGTALDGRVLLGAELATGDEQVDVSELPPKLRAGLGAYFQSRPHEGLDVLIAHEAVHTRQKVPADVLVDQVVYEGVADFVAEQVTGRLPALAYVTYGPQHDAELRERFREAQDSTRFAPWLWSGPDNAEGVADLGYYVGYAIARAYHAKAPDKQAALQRMIELDYADTAAVKTFVRESGYLE
>NC_017030.1|WP_014397022.1|5309578_5311672_-|S46-family-peptidase
MKRLVVIAALVGAAPALADEGMWTYNNFPAAKVKEKYGFQPDQQWLDKLRLGAVRLAGGCSASFVSPDGLVMTNHHCARGCIEQLSTAKQDYLANGFYAKTQAEEKQCPAMEVNQLVEITDVTEQLNKATASLTGKQYSDTLKAEMSKVEKACSNGDDKVRCDLVTLYQGGKYNLYKYRRFQDVRLVFAPEHAIAFFGGDPDNFEFPRYDLDVTFVRVYQDKQPVKTPDYFKWSEGGAKENDLTFVAGNPGRTSRALTIAELEYTRDVSLPKTLMYLSELRGMLTEFQKRGPEQKRISSNLLFGVENGLKASKGRHEALLDKKFFASKVAAEQELRKKVDANPELKKKYAAAWDEIAKAEAQLLTIREELNFIEQGNGLSSSLFHIAKALVRAGDELPKDNGQRLREFNDANQPALKAQLFSPAPIYPELEIARLTYGLTKMREELGAKHPFVKKVLGKESPEQVATRVVKGTKLKDPKARQALWDGGKKAVDASKDPMVQLALLTDPDSRAIRKKFEDEVESVIKKNSELVAKAKFDIYGTSQYPDATFSPRVSFGSVKGYTDNGQQVAPITQMSGTFEHATGQDPYALPKSWLKSEKVITGTTPMNFVTTNDIIGGNSGSPVVNKNQEVVGLVFDGNIQSLGGEYGFDESVNRTVAVHSEAIIEALQKIYGATRVLEELRPGSTKVPPVKANPAG
>NC_017030.1|WP_014397023.1|5311871_5312648_-|helix-turn-helix-domain-containing-protein
MAARSDNALAPRADLSRFVQRVRVLWRGPSSGDYVRVPDGTVELVVRVTSTTCDVHALGPREQVVRKAPSEVPPDTLGIQFKPGGAYPFFGLPMSELAHRSLSIDTLWGKADGAKLREALAEAPSSQARLRTLEAALAERLHRDDVYEPAAAYLVRRGIRLLTGSRELPRVAELARTLGVSERHLRRAFDDVLGMGPKSYARLVRFQRALHASTDQGARPDWGSIAAGAGYYDQAHLIADFRAVLGTTPGAWLRAQAA
>NC_017030.1|WP_043321608.1|5312754_5313570_+|MBL-fold-metallo-hydrolase
MRIHHLNCGTLCPSSARFVTGSGGLFEPARMVCHCLLLETPRGIVLVDTGLGTQDVQDARGRLGQRFVSRSAPRLDASETALAQVERLGFRREDVRHIVPTHLDMDHVGGLADFPDAQVHLFADEHAAAMAGKRQGYKPVQWAHGPKWNPYAVDGERWFGFSAVRLIPGLDAEVLLVPLTGHSAGHCGVAVKGPAGWMLHAGDAYFSHHEVDPVAPRSPWGLALFQRLFSENNAVRIQNQERLRGLVRAHGHEVKVFSAHCAVEFDRMRAA
>NC_017030.1|WP_014397025.1|5313595_5314918_+|amidohydrolase-family-protein
MRRALLFGSLLWSLSSASAAEPARVQVLKAARLFDAKAGKVVTPGVVVVSEGRVVGVGPKAPVPEGASVVDLGDATLLPGFMDAHTHMTVEPGPDWRKDLIDGFQRTIPEQTLDTLPWARATLMAGFTTVRNLGAEDFIDVGLRNATARGIVVGPRILAATSSLSSTGGHCDYGNSFRKGLLAEDASRGVADGPDALRAKVRENVKYGADVIKVCATGGVMSLNADPDAPQFTQAELDAVVDEAHAHRRKVAAHAHGAEGAKRAIRAGVDSIEHGTLMDDEGVALMKQKGTWYVPTAFAFFGIKELADQGKLPPDTVAKLRAVDRRREHVLRKAISLGVRIAFGTDAGVFAHGRNAEEFALLVQAGLTPAEALRTATVNTAELLGVSDKLGTLEQGKLADVVAVPGNPLQDIRVTQKVFFVMKEGVIHRDDTAATSRAAP

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Crispr_ID: NC_017030_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_16

5746533-5746614

Orphan

Consensus_repeat	Method
GGCTTCGCGGCGACCTTGGGGGCCTCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_16

>merge|NC_017030|16|5746533-5746614|CRISPRCasFinder
GGCTTCGCGGCGACCTTGGGGGCCTCCGCGGGCTTGGGCTCCGGCTTCGTCTCCGGCTTCACGGCGACCTTGGGGGCCTCCG

>NC_017030|16|14|5746533-5746614|CRISPRCasFinder
GGCTTCGCGGCGACCTTGGGGGCCTCCG	CGGGCTTGGGCTCCGGCTTCGTCTCC
GGCTTCACGGCGACCTTGGGGGCCTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014397342.1\|5744654_5744837_-\|ribbon-helix-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|289422
NC_017030.1\|WP_014397354.1\|5754267_5754951_+\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|350376
NC_017030.1\|WP_014397335.1\|5736027_5737155_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
NC_017030.1\|WP_014397340.1\|5742655_5743600_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187566
NC_017030.1\|WP_014397348.1\|5749741_5750131_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397346.1\|5747115_5748162_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_017030.1\|WP_014397353.1\|5753631_5754252_+\|DUF1877-family-protein	unknown	unknown	gnl\|CDD\|378105
NC_017030.1\|WP_014397352.1\|5753249_5753594_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397355.1\|5754997_5755282_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397344.1\|5745590_5745953_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380343
NC_017030.1\|WP_014397337.1\|5738452_5739346_-\|aspartate-carbamoyltransferase-catalytic-subunit	unknown	unknown	gnl\|CDD\|234849
NC_017030.1\|WP_014397341.1\|5743670_5744630_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187541
NC_017030.1\|WP_014397343.1\|5744930_5745530_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_167594363.1\|5751807_5753130_+\|family-16-glycosylhydrolase	unknown	unknown	gnl\|CDD\|185683
NC_017030.1\|WP_014397339.1\|5740675_5742487_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_017030.1\|WP_043321689.1\|5739422_5740670_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_017030.1\|WP_014397350.1\|5750624_5751671_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NC_017030.1\|WP_014397336.1\|5737154_5738456_-\|dihydroorotase	unknown	unknown	gnl\|CDD\|236479
NC_017030.1\|WP_014397347.1\|5748256_5749522_-\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|237339
NC_017030.1\|WP_014397349.1\|5750202_5750631_+\|DUF4326-domain-containing-protein	unknown	unknown	gnl\|CDD\|372965

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014397342.1\|5744654_5744837_-\|ribbon-helix-helix-domain-containing-protein	gnl\|CDD\|289422	pfam12651, RHH_3, Ribbon-helix-helix domain. This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.	8.29305e-13
NC_017030.1\|WP_014397354.1\|5754267_5754951_+\|tyrosine-protein-phosphatase	gnl\|CDD\|350376	cd14527, DSP_bac, unknown subfamily of bacterial and plant dual specificity protein phosphatases. This subfamily is composed of uncharacterized bacterial and plant dual-specificity protein phosphatases. DUSPs function as a protein-serine/threonine phosphatases (EC 3.1.3.16) and a protein-tyrosine-phosphatases (EC 3.1.3.48).	5.77888e-29
NC_017030.1\|WP_014397335.1\|5736027_5737155_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NC_017030.1\|WP_014397340.1\|5742655_5743600_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187566	cd05256, UDP_AE_SDR_e, UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs. This subgroup contains UDP-N-acetylglucosamine 4-epimerase of Pseudomonas aeruginosa, WbpP, an extended SDR, that catalyzes the NAD+ dependent conversion of UDP-GlcNAc and UDPGalNA to UDP-Glc and UDP-Gal. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.55057e-131
NC_017030.1\|WP_167594363.1\|5751807_5753130_+\|family-16-glycosylhydrolase	gnl\|CDD\|185683	cd00413, Glyco_hydrolase_16, glycosyl hydrolase family 16. The O-Glycosyl hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A glycosyl hydrolase classification system based on sequence similarity has led to the definition of more than 95 different families inlcuding glycosyl hydrolase family 16. Family 16 includes lichenase, xyloglucan endotransglycosylase (XET), beta-agarase, kappa-carrageenase, endo-beta-1,3-glucanase, endo-beta-1,3-1,4-glucanase, and endo-beta-galactosidase, all of which have a conserved jelly roll fold with a deep active site channel harboring the catalytic residues.	3.50672e-16
NC_017030.1\|WP_014397346.1\|5747115_5748162_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_017030.1\|WP_014397353.1\|5753631_5754252_+\|DUF1877-family-protein	gnl\|CDD\|378105	pfam08974, DUF1877, Domain of unknown function (DUF1877). This domain is found in a set of hypothetical bacterial proteins.	3.38587e-20
NC_017030.1\|WP_014397344.1\|5745590_5745953_-\|cupin-domain-containing-protein	gnl\|CDD\|380343	cd02213, cupin_PMI_typeII_C, Phosphomannose isomerase type II, C-terminal cupin domain. This family includes the C-terminal cupin domain of mannose-6-phosphate isomerases (MPIs) which have been classified broadly into two groups, type I and type II, based on domain organization. This family contains type II phosphomannose isomerase (also known as PMI-GDP, phosphomannose isomerase/GDP-D-mannose pyrophosphorylase), a bifunctional enzyme with two domains that catalyze the first and third steps in the GDP-mannose pathway in which fructose 6-phosphate is converted to GDP-D-mannose. The N-terminal domain catalyzes the first and rate-limiting step, the isomerization from D-fructose-6-phosphate to D-mannose-6-phosphate, while the C-terminal cupin domain (represented in this alignment model) converts mannose 1-phosphate to GDP-D-mannose in the final step of the reaction. Although these two domains occur together in one protein in most organisms, they occur as separate proteins in certain cyanobacterial organisms. Also, although type I and type II MPIs have no overall sequence similarity, they share a conserved catalytic motif.	1.22035e-16
NC_017030.1\|WP_014397337.1\|5738452_5739346_-\|aspartate-carbamoyltransferase-catalytic-subunit	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	8.66557e-177
NC_017030.1\|WP_014397341.1\|5743670_5744630_-\|SDR-family-oxidoreductase	gnl\|CDD\|187541	cd05230, UGD_SDR_e, UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs. UGD catalyzes the formation of UDP-xylose from UDP-glucuronate; it is an extended-SDR, and has the characteristic glycine-rich NAD-binding pattern, TGXXGXXG, and active site tetrad. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.86637e-176
NC_017030.1\|WP_014397339.1\|5740675_5742487_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_017030.1\|WP_043321689.1\|5739422_5740670_-\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	2.91467e-41
NC_017030.1\|WP_014397350.1\|5750624_5751671_-\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.01982e-90
NC_017030.1\|WP_014397336.1\|5737154_5738456_-\|dihydroorotase	gnl\|CDD\|236479	PRK09357, pyrC, dihydroorotase; Validated.	0
NC_017030.1\|WP_014397347.1\|5748256_5749522_-\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|237339	PRK13299, PRK13299, tRNA CCA-pyrophosphorylase; Provisional.	4.01734e-97
NC_017030.1\|WP_014397349.1\|5750202_5750631_+\|DUF4326-domain-containing-protein	gnl\|CDD\|372965	pfam14216, DUF4326, Domain of unknown function (DUF4326). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 100 and 162 amino acids in length. There are two completely conserved residues (P and C) that may be functionally important.	3.28116e-19

>NC_017030.1|WP_014397344.1|5745590_5745953_-|cupin-domain-containing-protein
MTTTKRVEKPWGHELIWAHTERYVGKLLHVKAGHKLSLQFHNVKDETIHVQSGKLLFVVDEGQGLIEKEMNPGESYHIKPLTKHRMVAITDCDILEVSTPELNDVVRLEDSYGRTGTSAP
>NC_017030.1|WP_014397343.1|5744930_5745530_+|hypothetical-protein
MASSNRLIFLGFLAAGALAGCASQKAAEAPDAARKRPEAEGIRGKQDPGETVTELDANGDGRTDVWEYRLKDALVRKELDLNWDGRVDVTQYLDPQGVKVREVMDLDYDGKVDATYHYTEGKRTKGERDLNGDGRADSWLYYENDTLVRKERDANHDGRVDYWEYWENGQVDRIGEDLDGDGTVDQWTRNPNAAAKSKE
>NC_017030.1|WP_014397342.1|5744654_5744837_-|ribbon-helix-helix-domain-containing-protein
MARKKVSTTIYITPEQNELLKALNQKTKVPVAEYIRQGIDLVLEKYKAQLPGQATFDELS
>NC_017030.1|WP_014397341.1|5743670_5744630_-|SDR-family-oxidoreductase
MRGKRAVVLGGAGFVGSHLCERLLDDGAESVLAVDNLITGNEANVRTLKPRAGFQFVNQDITEGLEVDGPVDFVLNLASPASPIDYANLPIETLRVGSIGTENALKLAEKKKAVFLMASTSEVYGDPLVHPQKEDYWGNVNPIGPRSVYDEAKRYSEAISAAYERSRGVNVRIVRIFNTYGPRMRLNDGRVVPAFVGQALKGEDFSVFGDGSQTRSFCYVKDLVDGLVRLVLSDVRGPVNIGNPREMTIKQFAEAVREAAGGGRQIVYHPLPKDDPKQRQPDITRARTLLGWEPKVKLEDGLRDTIAYFREVAARPSGT
>NC_017030.1|WP_014397340.1|5742655_5743600_-|NAD-dependent-epimerase/dehydratase-family-protein
MKVLVTGGAGFIGSHVCDEFLRNGHEVIALDNLSSGKKENLDPRVRLAVHDIRSPEAAELIRTEKPQVLCHLAAQMDVRRSVEDPGFDADVNIRGMTNLLEAARQSGVKKVIFSSTGGAIYGEQDYFPAREDHPQRPVSPYGVSKAAGELYLGYYRAQYGLPYVALRYANVYGPRQNPHGEAGVVAIFSQRVIAGQGCTIFGEGKQTRDFVFGPDVARANYLAFQSDYVGAANIGTGVETDINRLYELIAQAGGSSLKAAHAPGKPGEQLRSCIDAAHAKKVLGWEPSVQLAEGLRHTIQFFRDQAAGPVRARG
>NC_017030.1|WP_014397339.1|5740675_5742487_-|elongation-factor-4
MPAENAHIRNFCIIAHIDHGKSTLADRLLEKTGTLTKREAQAQFLDNMDIERERGITIKAQSVRMTYTAKDGQNYVLNLIDTPGHVDFAYEVSRSLAACEGALLVVDATQGVEAQTLANVYMALDHNLEIIPVINKIDLPSADVDRTRGEIEDVIGIDASVAVPASAKEGLGIHDILESVVKRVPPPQGSPTAPLKALVFDSWYDNYRGVVTLVRVLEGTLKLKQKIKMFSNNKVFEVQELGVFSPFSRPVQQLMAGEVGVLVANVKELQDAKVGDTVTEEARPTEAPFPGFKEVKPMVFSGIFPVDSADYENLRDALAKLTLNDSAFTYEPESSTALGFGFRCGYLGLLHMEIVQERLEREYNLNLITTAPSVVYRITTSKGETMLVDNPAKLPPTQNIEKFEEPILTCHIHVPNEHLGAILKLCQDRRGVQKDMKYLGSSGTRVQVTYEMPMAEVVFDFFDRLKSVSRGYASLDYELSAYAEADLAKLDILINGEPVDALSVIVHRERAYLRGREVCEKLKEVIPKQMYEVAIQAAIGAKIISRETISAMRKNVLAKCYGGDISRKRKLLEKQKEGKKRMKQVGTVEIPQEAFLAVLKTEQ
>NC_017030.1|WP_043321689.1|5739422_5740670_-|signal-peptidase-I
MSTASPSMKLGAAMAARRTPEQLKARRQLMWRELLTSLWAPLCGVGLAFLPYVTLIEMAPGTASWAQPLMKGFGLLMVVAFFGLLVWRSASKKESLLRTLRHEAHELISEDERILARLGTKVPPAVADRITEQALRVESASVAGNPELLRTETQALEKLTQEHLGAYRKQSVWDFLGGFGKALLIAVVIRTVLIEPYRIPSGSMLPTLQIGDQVFVNKFIYGVRIPYTNYVPFRIVREPKRGDVIVFNNPVDESKDFIKRVIGIPGDTVEIVDGVVRINGEPQPRTLVTPDFVVHNQDDLTGRWFDQEEVLYRETLGDVVHSSLQHPMRLPGREHEGPYTVPANSVFVMGDNRDNSADSRYNLGGPGGAEVAYVPYGHIKGKAMVVWLSLGWGGLLGNLFGGTGLRVDRFFEPVR
>NC_017030.1|WP_014397337.1|5738452_5739346_-|aspartate-carbamoyltransferase-catalytic-subunit
MRHLLGIAGWRRDELEALLDRAQAHLPGGPDASHVLRGRVVANLFFEDSTRTRSSFEVAARKLGADVLNWSYAGSSVSKGETLLDTARNIEAMGPAVIVIRHRSSGAPGLVARHVKCAVVNAGDGAHEHPSQALLDAFTLRQRWGRLDGRTVLIVGDVLHSRVARSNLLCLKALGARVVLCGPPTLLPPGLEEMGGEVTHQLDAVLPQADAVMCLRLQTERMSEAFLPSQREYSRLFGITPARAERMKPDALVLHPGPINRGVELSPVVADGPRSVILEQVANGVAVRRAILEACAS
>NC_017030.1|WP_014397336.1|5737154_5738456_-|dihydroorotase
MTPVLFQRARVIDPRNGVDGVRDVLVTDGRVAQVSEAPLPAPKDARVVDATDKWLVPGFIDLHVHLREPGEEGKETVLTGCRAAVAGGFTGVVAMPNTKVVNDSALVTELVLSRARDAGLCHVYPAGAITKGLKGEELSEAGELIGAGCVALTDDGRPVMNAGLMRRVLQYATQFDVPVMVHEEDLTLSAGGAMHEGATSTRLGLRGIPSSAEVAMVARDLVLLEETKGRLHVAHVSCEGSVRLIREAKQRGLRVTCEVAPHHFTLDDRAVGDYDTHAKMAPPLRGDVDVKALREALVDGTVDAIATDHAPHGVSDKLVEFEKGINGIVGLETALGLTLALVHEGVLTPRRAVELLSDGPARVFGLPGGHLAPGAPADITLLSPSEEWTVDAHRFYSRSRNTPFHGRTLKGRVTQTWVGGRCVFEDGQLKESR
>NC_017030.1|WP_014397335.1|5736027_5737155_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MTKRAVLALADGTTFEGRAFGASGETVGEVVFNTSMYGYQEILTDPSYVGQIVTMAYPEMGNIGANATDEEAGLPHAVGMVVRSLTKTPSNWRSQETLDAYLARHGRVGIEGVDTRRLVRHLRTHGAQTGIISTENVSAAALSERARTAVGMEGLDLATGVSCKEPYVFTTPSPDVFLAPGDKRPEPELKYDVIAYDYGLKRSMLQYLVDVGCRVTVVPSHFTAEQVLAKKPHGVFLANGPGDPAAVKGADRTVAALLGKVPVFGICLGHQIMALALGGRTYKMKFGHRGGNQPVKDLTTGKVEITAQNHGFAVDDASLKGKAVVTHINLNDGTVEGLAVPDARAFSVQYHPEASPGPHDARYLFSRFATLMAGS
>NC_017030.1|WP_014397346.1|5747115_5748162_-|tRNA-2-thiouridine(34)-synthase-MnmA
MRVVVAMSGGVDSSAAAALLKEQGHEVIGITLRVWSYEGAAKCGSCCSPDDIDDARAVAQTLGIPFYVANAEEIFQDRVVNPFVQSYLGGRTPIPCVSCNRDVKFNFLLKRARALGARLATGHYAQVEEVDGRFHLRRAVDAAKDQSYFLFTLGQEELKDVLFPVGHLTKPEVRAVAERHHLPTTHKPESMEICFVPDGDYAGFVEKVAGPQPAGEVVDPDGKVLGTHNGIHRFTVGQRKGLNLGGGEVRYVQRLEPETNRVVVGPAEGTGRAQFGLLQPHWVDGPPPPEQAVEVRIRHRHAGAPGRIHISQHGLVSVKLDEPARAVTPGQAAVVYDRDRVLGGGWIV
>NC_017030.1|WP_014397347.1|5748256_5749522_-|CCA-tRNA-nucleotidyltransferase
MIANLHDADIPKPVLEVITRLRELGHPTYLVGGCVRDMVRKVHPKDFDVATSALPEEVQRAFRKVIPTGIQHGTVTVVTGGNHVEVTTFRSEGDYLDGRRPSSVSFERDIVKDLSRRDFTINAMAYNPLDRELVDPFGGQVDLPAKLIRCVGSAQERFSEDGLRPLRAVRFAAVLGFTLDPDTRDAIPATLAVFRKVALERVREELLKLLLSPRAEMGLHLLADTGLMAVFLPEVAHADAETVRLARAAVQAAPLDADLRMATLLADIDTATQARELCLRLKFPNKSADLIGLLVEHAKLETRVDDADPALRRLLARVGLVNLPALLSVAKARVQVQAPERLPAVEALAARLEALAAAKPPLSAKELALTGGDIMKTLGIGPSPKVGEATRYLVESVLDDPSLNTTDALCSLLTAWAARGS
>NC_017030.1|WP_014397348.1|5749741_5750131_+|hypothetical-protein
MFKVTSNHTFKNPSRLQIDQTTQGKKSDYSHAVSGVNQLLDKGNFGISDRSKNSVIDNVKKVETGARSEVNAHQREALNFGRDAFVSISKGQFKQGAVEALGSGLNAAASGFKSTYTPTPHEKQGIAPW
>NC_017030.1|WP_014397349.1|5750202_5750631_+|DUF4326-domain-containing-protein
MSESRTTAVHVHDACEVYVGRAFRAWAKPGPLNPVPGRFGNPFKPGGVKTWKAMIRTYFEPWLAKLPADEAERIRDEAQRRMAPGPDAFESFRWYLELRTKHDADFLRDVKTLRGKRLGCWCKPGPCHADVLAAWLDSGPRQ
>NC_017030.1|WP_014397350.1|5750624_5751671_-|alpha/beta-hydrolase
MPTDTKQPSDSGLDPHARAFLEQLKKAGGPALETLPPAEARGVLRSVQAGKSARKPARIEDRSLPVGPDGQVSVRIVRPADASEKLPVVLYLHGGGWVLGDKDTHDRLIRELAVGTRCAVVFINYTPAPEGQYPMQLEQAYAALQWVAKNGGEADLDGQRIAVAGDSAGGNLAAALTLLAKERGGPRILQQVLFYPVTDARFDTGSYARYADGYFLTRSGMQWFWDNYAPDSTVRTEPTVSPLRATDVQLRGLPPALILNGECDVLRDEGQAYARRLVDAGVPALALQYEGMIHDFVMLDPLADSLAARNAITQACLTLSEALGTRKQVEAGLTSQPAQVRERESARH
>NC_017030.1|WP_167594363.1|5751807_5753130_+|family-16-glycosylhydrolase
MSESAVLRRPRFRTALALLLALPLASSCSPEPGTDTPVQSEAPLASVITNTSFETNTSGWSSWQGTLTREARTGAPDGQYVARVTVSGAATLYSLDGAQSSIPNAPQGQAYTATAYVAAGNSGTVGKPVSLILREKNASGTTYKLFTADATLTTGFQRLSVTGTVERVGDTVDVYVLQNQATSGNAILVDAITLETAGGGSSPSGEPMPVGDLTNWRQVFTDDFTTNVPVGQFPAAVSSRWGVYPDGWKDTSKNGTYSPSKVVSIQNGVLNKYLHTENGVHRVAALLPKIPGANAAGGLPAGRYAIRFRADAVPGYKVAWLLWPDSEVWPRDGEIDFPEGDLNGTISGFMHRQNGTSGGDQDAASSSARFTSWHTAIIEWTPGRCRFILDGTVILDKTSRVPNTAMHWVIQTETDLSGTPPSNSAAGNVQIDWVAVWVPK
>NC_017030.1|WP_014397352.1|5753249_5753594_+|hypothetical-protein
MAVQYDPSIITKHAQALYTKASGIIFAWSVIGFIAGLAMTTAMNTNAPGPIVVLGGLVVALIGAVFGRGRAFSLQLQAQVALCQVATEANTRRTANAVAAAVPSPAPESVNRAS
>NC_017030.1|WP_014397353.1|5753631_5754252_+|DUF1877-family-protein
MGLDASYQALPGGSPLLELARRNIGVGGWLMSVTRLLRAPREETLAPGAPESDELLLLDAVRDLLRTRPDLATQQVDLGRRWDHLHFVLSDRRRNAQGTEDDSLAGIAIHGEAEIAPHVVAPQGVPLRYTRPETVERIARMLEAVRFDALREHFTFKRLSDAAVYKCPREEGIDEAWQWLTERFDRFRAFYVTAAKHGDGVLVCVD
>NC_017030.1|WP_014397354.1|5754267_5754951_+|tyrosine-protein-phosphatase
MKYTFVFTTAAALLTFLAQRLQGLGWLLLWPALSFAFLALAYAGLGARVFGKQPDGRMQPWAVFALLPYLLLTWGTWHLARRFSRERAFDEVVPGVLVGRRLLTGELPAGVTAVLDLTSEFIEPEGIRAAGRYVSLPILDASTLPVEQVAPVLRELAALPGPVYIHCAQGHGRTGMIAAALLEARGDAPDAKAALARVRQARPGVRLSALQERALDALSAALRPAGV
>NC_017030.1|WP_014397355.1|5754997_5755282_-|hypothetical-protein
MNALKKSLMAVAAVFAVAPSAAFAYPPQCWDVCVGYCDQICYEGTYRTTCGDVVGCFAPAQPSEETASVSTEQAQQSEDAALVCDAEQTPAVES

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Crispr_ID: NC_017030_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_17

5823755-5823861

Orphan

Consensus_repeat	Method
GGCCACCTCGCCGTCCAGCCGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_17

>merge|NC_017030|17|5823755-5823861|CRISPRCasFinder
GGCCACCTCGCCGTCCAGCCGCGCGAGGAGCGTGTCTACGAAGTTCGCGCGCATCGCTCCACCCATCCGCTCCACAGGGCCCGGGCCGCCTCGCCGTCCAGCCGCGC

>NC_017030|17|15|5823755-5823861|CRISPRCasFinder
GGCCACCTCGCCGTCCAGCCGCGC	GAGGAGCGTGTCTACGAAGTTCGCGCGCATCGCTCCACCCATCCGCTCCACAGGGCCCG
GGCCGCCTCGCCGTCCAGCCGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014397412.1\|5819711_5820941_-\|CapA-family-protein	unknown	unknown	gnl\|CDD\|214858
NC_017030.1\|WP_014397419.1\|5829264_5829696_-\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NC_017030.1\|WP_167594366.1\|5833257_5833728_-\|DUF3592-domain-containing-protein	unknown	unknown	gnl\|CDD\|378822
NC_017030.1\|WP_014397409.1\|5817645_5817879_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397411.1\|5819097_5819709_-\|iron-containing-redox-enzyme-family-protein	unknown	unknown	gnl\|CDD\|379634
NC_017030.1\|WP_014397425.1\|5837720_5839673_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|223963
NC_017030.1\|WP_014397426.1\|5839676_5840834_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NC_017030.1\|WP_014397424.1\|5835524_5837717_+\|TOMM-precursor-leader-peptide-binding-protein	unknown	unknown	gnl\|CDD\|376866
NC_017030.1\|WP_014397413.1\|5820937_5821918_-\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|225779
NC_017030.1\|WP_014397408.1\|5816638_5817616_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397406.1\|5814324_5815248_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176161
NC_017030.1\|WP_043321700.1\|5815337_5816354_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293806
NC_017030.1\|WP_014397414.1\|5821925_5822537_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224931
NC_017030.1\|WP_014397405.1\|5813957_5814296_+\|UBP-type-zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|366940
NC_017030.1\|WP_014397410.1\|5817933_5818359_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397417.1\|5825195_5826785_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|375882
NC_017030.1\|WP_014397423.1\|5833755_5835429_-\|S8/S53-family-peptidase	unknown	unknown	gnl\|CDD\|173788
NC_017030.1\|WP_014397421.1\|5830693_5833243_+\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NC_017030.1\|WP_167594364.1\|5829995_5830697_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226702
NC_017030.1\|WP_014397418.1\|5826848_5829263_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226702

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014397412.1\|5819711_5820941_-\|CapA-family-protein	gnl\|CDD\|214858	smart00854, PGA_cap, Bacterial capsule synthesis protein PGA_cap. This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.	4.46711e-53
NC_017030.1\|WP_014397419.1\|5829264_5829696_-\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.96767e-56
NC_017030.1\|WP_014397425.1\|5837720_5839673_+\|radical-SAM-protein	gnl\|CDD\|223963	COG1032, COG1032, Fe-S oxidoreductase [Energy production and conversion].	2.21127e-25
NC_017030.1\|WP_167594366.1\|5833257_5833728_-\|DUF3592-domain-containing-protein	gnl\|CDD\|378822	pfam12158, DUF3592, Protein of unknown function (DUF3592). This family of proteins is functionally uncharacterized.This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 150 and 242 amino acids in length.	4.46763e-08
NC_017030.1\|WP_014397411.1\|5819097_5819709_-\|iron-containing-redox-enzyme-family-protein	gnl\|CDD\|379634	pfam14518, Haem_oxygenas_2, Iron-containing redox enzyme. The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase.	3.69342e-14
NC_017030.1\|WP_014397426.1\|5839676_5840834_+\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	5.81801e-23
NC_017030.1\|WP_014397424.1\|5835524_5837717_+\|TOMM-precursor-leader-peptide-binding-protein	gnl\|CDD\|376866	pfam02624, YcaO, YcaO cyclodehydratase, ATP-ad Mg2+-binding. YcaO is an ATP- an Mg2+-binding protein involved in the peptidic biosynthesis of azoline. There three motifs involved in the binding are, in UniProtKB:P75838, 71-79: Sx3ExxER, 184-203: Sx6Ex3Qx3ExxER, and 286-290: RxxxE. Three slightly different functional families are represented in this family, proteins involved in TOMM (thiazole/oxazole-modified microcin) biogenesis, non-TOMM proteins such as UniProtKB:P75838, and TfuA-associated non-TOMM proteins involved in trifolitoxin biosynthesis. UniProtKB:P75838 hydrolyzes ATP to AMP and pyrophosphate.	8.15959e-99
NC_017030.1\|WP_014397413.1\|5820937_5821918_-\|fatty-acid-desaturase	gnl\|CDD\|225779	COG3239, DesA, Fatty acid desaturase [Lipid metabolism].	6.74746e-24
NC_017030.1\|WP_014397406.1\|5814324_5815248_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176161	cd08472, PBP2_CrgA_like_3, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 3. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.17581e-93
NC_017030.1\|WP_043321700.1\|5815337_5816354_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293806	cd07720, OPHC2-like_MBL-fold, Pseudomonas pseudoalcaligenes organophosphorus hydrolase C2, and related proteins; MBL-fold metallo hydrolase domain. Pseudomonas pseudoalcaligenes OPHC2 is a thermostable organophosphorus hydrolase which a broad substrate activity spectrum: it hydrolyzes various phosphotriesters, esters, and a lactone. This subgroup also includes Pseudomonas oleovorans PoOPH which exhibits high lactonase and esterase activities, and latent PTE activity. However, double mutations His250Ile/Ile263Trp switch PoOPH into an efficient and thermostable PTE. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	4.28355e-106
NC_017030.1\|WP_014397414.1\|5821925_5822537_-\|isoprenylcysteine-carboxylmethyltransferase-family-protein	gnl\|CDD\|224931	COG2020, STE14, Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones].	2.41637e-12
NC_017030.1\|WP_014397405.1\|5813957_5814296_+\|UBP-type-zinc-finger-domain-containing-protein	gnl\|CDD\|366940	pfam02148, zf-UBP, Zn-finger in ubiquitin-hydrolases and other protein.	2.2658e-09
NC_017030.1\|WP_014397417.1\|5825195_5826785_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|375882	pfam18456, CmlA_N, Diiron non-heme beta-hydroxylase N-terminal domain. This is the N-terminal domain found in Diiron non-heme beta-hydroxylase (CmlA). CmlA catalyzes beta-hydroxylation of the precursor molecule l-p-aminophenylalanine (l-PAPA) to form l-p-aminophenylserine. Structural analysis indicate that the N-terminal domain facilitates dimerization and has a mixed alpha-beta topology. Furthermore, a projecting 'dimerization arm' (residues 108-146) from the N-terminal domain of CmlA mediates the interaction between the monomers.	2.40453e-108
NC_017030.1\|WP_014397423.1\|5833755_5835429_-\|S8/S53-family-peptidase	gnl\|CDD\|173788	cd04056, Peptidases_S53, Peptidase domain in the S53 family. Members of the peptidases S53 (sedolisin) family include endopeptidases and exopeptidases sedolisin, kumamolysin, and (PSCP) Pepstatin-insensitive Carboxyl Proteinase. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of Asn in subtilisin. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Characterized sedolisins include Kumamolisin, an extracellular calcium-dependent thermostable endopeptidase from Bacillus. The enzyme is synthesized with a 188 amino acid N-terminal preprotein region which is cleaved after the extraction into the extracellular space with low pH. One kumamolysin paralog, kumamolisin-As, is believed to be a collagenase. TPP1 is a serine protease that functions as a tripeptidyl exopeptidase as well as an endopeptidase. Less is known about PSCP from Pseudomonas which is thought to be an aspartic proteinase.	6.05707e-83
NC_017030.1\|WP_014397421.1\|5830693_5833243_+\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	7.15763e-60
NC_017030.1\|WP_167594364.1\|5829995_5830697_+\|hypothetical-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	1.06316e-49
NC_017030.1\|WP_014397418.1\|5826848_5829263_-\|PAS-domain-containing-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	4.15959e-53

>NC_017030.1|WP_014397414.1|5821925_5822537_-|isoprenylcysteine-carboxylmethyltransferase-family-protein
MKGLRDAPALYLGFISLHLLLGHLGASLVYRLRFGRGPLAYRSTRADSAHTRLTRRISGVSLVWAGSVVAAALWPRWSELPWGRPLLALPPEVGWALGVLGLVGMLAAQYGMGAAFRIGVDAGEAPPVLHERGLHRCSRNPIYIFSYLYLVGASLWAPSLVTLGACAVLGGLFHGLVLQEERYLSARLGEAYARYRQRVPRYL
>NC_017030.1|WP_014397413.1|5820937_5821918_-|fatty-acid-desaturase
MQPALAPVLASPAAPAGPGPSRDEWVELLRIRPARALGMAALHLGVWGLAGVGLAHVSGFWLKLPLWLLAAQGVMGLIQLDHDAWHDTLFPRPWQNRLFGNGLSLLVGIAYEPMRHDHLAHHRWNRTEKDPDAYNAGRRSPGLWALFYATVLLGLPLSLVYFNVLYPVQHFDAARLRRHARVLLGYGAFYALLFWLLAGHGLLGSAVECWLVPVLFASPLNGLKSISDHHANVWRGDRFHTATTVRSTRLVTFLWNGLNHHLDHHLYPRVPGYNLARLHARLRPGLLARGAPVFDSYLHVMWRALLAGPMVVEEDVRLVTLERKRP
>NC_017030.1|WP_014397412.1|5819711_5820941_-|CapA-family-protein
MNALRRLYADLRYEDGRWPLSRWDLNLRYITKSLLHLPQPRSAETGEHFARVARHLASGSWRHEGAPELRLSAVGDMMWIRSGFHRALSPGVREVMANDAVAFANLETPVDPARPVPRLVYETLHYNAPPDYLAAWEGAARHRVFSLCNNHALDQGAEGLERTRGTVLASSQHRCVGGPRPEDAVAALEVDGVRMGIAAVTYDINHLVGAPPAGVPVTRLGSPLHAPDWERLGALIDAARAVGPDLVVLMPHWGFEYEYWPEALQREHAWRLIERGADLLLGSSPHVLQPVEWVSIDGADATCPTQVRRGGPARMGLIAYSLGNFLSIMPTLACQTGAVLKLALARDARGVLQPVDLRAVPTACGRGLGGEGLLDAGVVRLDELPPQRAAPHLAHARRTLGALLSDRRD
>NC_017030.1|WP_014397411.1|5819097_5819709_-|iron-containing-redox-enzyme-family-protein
MSSIEEQLEALTVGMARQVASWLPAVTPERYVAFLDMMYHYTRRSGDRLRLAAERATLPELKDFFTELAGDEQSHYLLARADLAAFGREPSSDTPREVADFHAFWEGIGPERQLAFLGALRVLEGVARHLGGEARQGLGRLGLERTKARFILVHLDVDLEHGARAQALCAALGAGHPEPLLEGARRAADFWVAIHRAALAGET
>NC_017030.1|WP_014397410.1|5817933_5818359_-|hypothetical-protein
MNRQAMFAALAVLCLTACGGAMDEQADLSAQKAAVLSSTDPLVGKWCHASWPGCFTISSSGSGIMANNGDGCWLTGDVKFSGLTPGSTAGTYTGTRNHRGSGVCASPPPYPLPTSTTITMTGPDSFTEVSGSFTASWFRSP
>NC_017030.1|WP_014397409.1|5817645_5817879_+|hypothetical-protein
MRYTRKNISELLDAVQGNPDVMGFWTSNFAGSAFTLVPSPGGMIWQDVYSPSRQICEDGIPYGTEDGMNNHCGGTGY
>NC_017030.1|WP_014397408.1|5816638_5817616_+|hypothetical-protein
MVLLACLWAADQLTSEWKALLNKETQLLKLWSGVGVFFSANTHPLGSFTSVVLSPRGKAGGGSSDWGFYSVELKSPTRTVAVSGSNDRDEALELAQALSRFLGVDLSVDGGHARPPDARLEAAPLEREQAPPSLPPGSRIRVRQGAQGLVLQLPGCGWRPLFVVKAGIALVIAVGGPAVFGLAWVRTYGLRQLTSAEPLMALAVFLCLGGLLLWSVIREVNRGWSLAASSQGIEHSRTRGGKPGEVTRLPASQIEDIDLREPEEEFFGSLTVVIEHKKGFVRIGAGLSREELEWTETMLRRALATRRAPRDDGDSPLLMRAATRN
>NC_017030.1|WP_043321700.1|5815337_5816354_+|MBL-fold-metallo-hydrolase
MKTTPARGAFLAVSRALTLLMLSGAPLLSSSVHAAAPQVRTQAPGFHRMMLGDFEVTALSDGTVPQTVSEVAKGTTPGRVKELLSRDHLEDPIEASINAFLINTGTALVLVETGSGSFFGPGVGGQLQQSLQAAGYRPEQIDVVLLTHIHSDHSGGLMSKTSRAFPNAILRAHAREVGFWLGRDGQAKGSVDPKFFEEARAMVGPYQDAGKLKTFADGDAIVPGIRAMPTPGHTPGHSVYVVESRGARLVLWGDLMHFGSVQLREPSVTVAYDVDERAAAAQRARAFTEAAKRGDLIGLAHMPFPGLGRLSAEGKGYRWIPLNYSSGQRWEDTKARAE
>NC_017030.1|WP_014397406.1|5814324_5815248_-|LysR-family-transcriptional-regulator
MDTFTAMEAFVRVVETGTFTKAADALGRPKAAVTRLIQQLEAHLRVKLLHRTTRRVTVTPEGMTYYQQALRLLGEVRELEATLSQSRRGPRGRLRVESSGTISRLLLIPALPSFYARYPQMHIELGVSDCVVDLLADNVDCAIRGGAVKDESLVARHLGDLCYWLCASPRYLERHGAPLHPLELAGPAHAVVSYFSSLSGKENPFVFVREGERLEVRGRSLLTLNETNAYLAAGLAGLGVMFAPRFVVEPYLASGELVRVLDGWRPEPRPLFLVYPPSRQLGAGARVFIDWLTELFASRPNLWRDDG
>NC_017030.1|WP_014397405.1|5813957_5814296_+|UBP-type-zinc-finger-domain-containing-protein
MKKACPHLEDTQQHRTAPVHPSSHGCMECLKDGGDWVHLRMCLTCGHVGCCDDSPSRHATQHFHASAHPVMKSFEPGENWAWCFVDEQFLDRIPTFPGESPPVHYSAPMSAP
>NC_017030.1|WP_014397417.1|5825195_5826785_+|MBL-fold-metallo-hydrolase
MLDRPMYLKPDVAIEPLFNQWYVWWYLISPATAPLFVSRLHLKLMQSFVANPDVHVAALQNPALMGGPFINHPVSRVNEVKALLDRTTREQADMLAYTKAVSDLEQLLASSKGESLEPLYAKVPDMLRGFVELHYDLAHRANARIMEPLLYRSSLYKESAQSISLMRVAGDARKYVFSTPRLEGDSPLWLQVPYRHEGIDALFRMRHTPGSPGQVAEMLGVPSSAAEAFADLFTETAPRKPEPYTGSGVRVRYFGHACVLMETREVSVLTDPVISYEFPTDQRRFTHADLPEKIDYVLITHGHADHLMMETLLQLRHRIGTIVVPRSNAYSLADPSLRLVLEKTGFKNVIEIDDLQEIQIPGGSLMGIPFIGEHSDLAVQAKTAHLVRLAGRSLLMAADSNALEPRMYQHLSELVGPLDALYLGMECEGGPMSWMYGPLLSQPLPRKMDQSRRLNGSDSARATEILNHLNPKEVFIYAMGQEPWLRHVMVLQYDETAPQMIESNKFIEVCKGRSIPAARPFLSMERILE
>NC_017030.1|WP_014397418.1|5826848_5829263_-|PAS-domain-containing-protein
MTVQWKPATDAAARVFPDGGELGALCRAKDWSAHPLGPVDGWPQSLKTAVSMVLGSQFPLIVLWGPQLYQFYNDGYRLLMGTKHPGGLGQGNKECWPEVWHINETIYPRIFNGETVTYEERMYPLAPHGYPEEYFLTLCYSPVRDETGAVGGVLVSIFDVTREVRARNERDRALAEARAERERLYEVFMQAPAVIAVLEGPEHCFTVSNPLYQQLTGNRDLIGKPLREALPEIGDQGFLQLLDNVRSTGKPYIAHDALVRLDRKGTGAVEDVYVDFVYQPLKDASGSVFGIMAHAVETTEQVLARRSIEALAAERVAMLGHIADAVITFDTAGRVSFINEMARTLYPGLRVGEPFAAQGFRQERVDGTPLSADELPPARAGRGERVLNEVWNIHTSDGHRQRVQGSAVPVYTDTRVHLGVVLTLRDITQQHRLEQQLELERNRLTQVFMQAPASIMVARGPQHVIQVVNPGYDQMTGNRPLVGKTIPDAFPDLAGQGLFELYDQVYATKQPFVGNEVPVRVARFGRVDDAYFNFVYQPLIDEDGETFGVMTHAVEVTDMVRSRQQAEERTRELVRLTQALEQSNRELDQFAYVASHDLKAPLRGIANLAEWLKEELGSNLTVEAREFITLLHGRVHRMEALIDGILTYSRAGKLSDPAAVDTGALLKEVVELLAPPPEAEVKVQPGSPTVSAERVKLQQVFLNLIGNALKFTRLHRPDPRIQVTWRDAGEQYEFTVADNGPGIAPEFHERIWGIFQTLESRDKVEGTGIGLSVVRKIIETRGGRAWVDSVPGEGAAFRFTWPKT
>NC_017030.1|WP_014397419.1|5829264_5829696_-|response-regulator
MTTATSGDRTLHILLIEDDEVDVMNVRRAFQKNHIANPLYVATNGLEGLEMLRNGAVPEGRRLVLLDLNLPKMNGIEFLRVLRADPELRTVSVVVLTTSADERDKIDAYNLNVAGYLLKPVTFINFVEVMATLNKYWTLVEMP
>NC_017030.1|WP_167594364.1|5829995_5830697_+|hypothetical-protein
MRKALRQNSADLEQFTYVASHDLRAPLRGISNLSQWLEEDLGPQLSQGSRRQMELLRGRVQRMEGMLDGLLDYSRAGRVHHKPEPVPVDRLIHETLERLAPGPSARLEVGPGMPVLVTERPALQQVFQHLLSNALKHAGREDVRIRVEVEATPAFHHFSVADDGQGISSRYHEKIWSPFQTLVSRDKVEGAGMGLCVIKKLVESRGGRTWVESAEGAGATFHFTWPGSEERLT
>NC_017030.1|WP_014397421.1|5830693_5833243_+|response-regulator
MSDTPASTSSVEVPPLTERLRLLLVDDDEVDRLLVQRLLGTTGLAVDVVEATSGSEALEQLKARSFDVILLDFFLPGEDGFWVLRELGSRGSRSPIVVLTGQGSEQTAVELMKAGASDYIAKSRLSAERLEQSLRQAMRLHLAEQRHRALAEALPQIVWTAGPDGRPDYFNQRWYDYTGLPARPASEERGSAPPLLPRDVLHADDVVGCLDRWSESRQAGGPFECEGRIRRRSDGAWRWHLIQALPLRNAHGRILQWLGTCTDIDDQKRAAETLSFLAEASTMLTASLEMSVTLERLSALILPRLGDWCAVYLQDDDGPVRQAMAAHVDASRVPLLREQHRAFNPSATASHGVARVLRTGMPELVPELTEAVLHEALGPAGDDARIRPGSWIIVPLWAQRRVFGALMVCALPSGRRYGARDMELVQELARRAEIAIDNARLFEMAKAEHLGAEQANRAKDEFLAAVSHELRTPLMAMVGWTRMLRSGQLGPDKAARALEAVERNTQVQTQLIEDLLDVSRIITGKMRLEIRPVVPGMFIEAALDSVRHAAEAKGVTLCAELPPGSGSIHGDADRLQQVVWNLLSNAIKFTPRGGQVTVRLRWVEGHVVIEVQDTGQGIPRAYLGQIFERFWQVDGSSTRKHGGLGLGLAIVRHLTELHGGTIEATSQGEGHGALFRLTLPLATAASSRGSAPLVQVQARQEVPSLDSGVLKGLQVLVVDDEPDALELLAVVLESRGAQVFTASSARQALEKHQFHRPHVIISDIGMPGEDGYSFIRRLRALPLEQGSQTPAIALTAFARMEDRTRALLAGFQMHVPKPIEPAELIIVLASLTGRHPQVDSQFQAARQAP
>NC_017030.1|WP_167594366.1|5833257_5833728_-|DUF3592-domain-containing-protein
MRNLLMILTFGGLFFGVIFGIGAWMIHSSAQAFLARPTVQGRVLEMAVEMGYSKSRYWRVKARYAYEVDGQSYVGETLSNETPRELLLWNPQPSPALTRYVERYPVGSTVTVRYNPKEPRRSLLEVNPDAARGPALAAGIALLVAVLSLVGQRFVR
>NC_017030.1|WP_014397423.1|5833755_5835429_-|S8/S53-family-peptidase
MARIPLTQSARVSPASLHPPLRSRSATGTVEVTLLLRHGAPLPTVEELCANPPRRPLTHDEFEAKYGTNPKHLAAVRRFAKSHGLTVTTERRDRGYVVLQGSTAAVRKAFEVDLRRYTHGKRSYLTHTKPVRLPRALEGVAEWVLGLDTRPLVTHNAAALPIPKEMAKQAGLRTYTAPQVANLYRYPRNQGEGQCVGIIELAGGYKQSDLDAYLKSMGVERTAPVVNVGPNKAGALNTASNAEVTMDVELVASVCPAARVVVYNAGSKDYSLRDYHRVLAEAISDRENRPSVLTTSWSFYEGSLIQQGEELAFERLFIEAALLGITVCAASGDLGSQVPVNAHSPTGAITLAATSYPAASALVLGCGGTTLEAVGDVLHHERVWNRLGEAMSMGPSSTAAGASSGGVSTMNALPLYQQGMGVPDLVMSSWKNGVFSVSRSTGRGVPDVAANADLHTGYQIVFKGQQGVAAGTSAAAPMWAALIVRLNEALGERVGFLHPRLYALVTEGQPVVRRITHGGNGAYFASDATLWNACTGLGTPDGEALLTGLRRLQRRKH
>NC_017030.1|WP_014397424.1|5835524_5837717_+|TOMM-precursor-leader-peptide-binding-protein
MDRVLRIKPHLRAEVLDARRVFLVGERAQFLLEGELHASIVPLLDGERTVENVIAALAGRASAPEVLYALSLLEERGHVEEAHDVFDASVAGFWESLGVGAATAAGRLLDVSVSVHAVDGEDGEGLAEALRDTGLDVCDAADRRVLLVDDYLSQEALALAEEARSAGAAFLPLKVSGTACHAGPVVGTGERACWTCLTARLLDNRPIEKYLARKGTPPRAIRPPRTGLPTTAKAGLSFAATLAARWVVDGPGRPGQTRLWTLDFATWKLESHAVARRPQCPDCGDPHWMEARAKKPLELASRSKRFTDDGGHRILTPEQTWERHRHLISPVTGVVSDLRAVPGDAPLGHIQSAVFRVCPWTDAPASDDFHRVASGKGRTEAQARAGALCEALERYSAVFQGDEPRVHATASQLGAQAVHPDALQHFSSAQFQSRPETASRDMRTAVPRPYADQPMDWSPAYSLTHGVHKYVPTSFAYLFAPPPPSGDGPFCFFNSNGNAAGNCVEEAILQGFLELVERDAVALWWYNRLRRPRVDLRSFDEPWFASVSAHYQSLGLQLSVLDLTHDLGIPVFAALVWSPERGRAWAGCGCHFDAKLAVQRALTEVAQCYDPKDVSPSPWDASAHGDVSWLFPNDLVPARVRADFPHMGHNDLRDDVRECVTRAASVGLETLVVEQSRPDVGVSAVKVIVPGLRHFWPRLGPGRLYDVPVRMGWLKAPKTEAQLNPVPFYF
>NC_017030.1|WP_014397425.1|5837720_5839673_+|radical-SAM-protein
MAPPPAPKPRILLVQCGPDRRHVDRETEDFDPERGLVKRATMTPLACATLAALTPDAFTVDIWDEELHGQLRADTELPDYDIVGVSVMYSALTYQARFLGGHFRDRGATVVAGGPAISAAPEDYRGFFDALFVNEAERTWPRFLADWLGGEYAPEYRQLEKPSLSESPLPRWDAIAADLPRYAWGSVQTTRGCPFDCSFCDVIYLYGRKQRHKPVERVLDEVRAHAALGAEGVFFADDEFIGDAAYAKEVLAGLVPLNRALPRPLRFFTQVTMNLSRDAALLEGMADANFYTVVLGIESFDTGALKEAQKHQNVRADLVGDLLRIQAHGIGPRGSFIVGFDHDTPAVFDSLHANIQRTHLPWVVVAPLQAPRGTKLWTRLRAEGRLATPRRAHAKDRGAIVLNVMPLGMTRPQLLEGFRDLVERLSTWDAACERIRGFIAGIQRPPQVEEPHWPEAVTDRFLREATAAWALTPSERHALGDTLAQVRRTAPAMLPRAVFFLARNQNERRRHERLFTDFDAVLAAERQGDLVPDTQPVYVPPGFATAMRDVFPDLFVRLSRDLPDRRDVPEASRDVLVDFVARWGEGFQALQPQHHEFLRELCDREVAARGGHPGTLEVVEEQALRTQARRTGLLEALLKDVRDELASWGP
>NC_017030.1|WP_014397426.1|5839676_5840834_+|amidohydrolase
MRDGLHIFDADRHVLEPLSLWAEQLEPGLRRHAPRPGRLPDETLEERLERLGPQGLLPVLPLPEVDGKPLWNHMPEKAWLAFSERSYAQLGRNELLQRPDVYLAQMDRDGVDMAALFPTYALLLEGFSPLEPHVATAFASVYNTWLHGFCAHQPERLRGVGLISRHQPEAMVAEVRRVAGFGWRAVMVRPNPIGGRLLSDAAYEPFWSECEKLSLAVVLHGSGHVYVPSAGADRFDTRFANHVCAHPMELMMGLLALLQGGVLERHPALRIGAMEAGCGWLPYWAWRLDEEYRAVGAEVSATIRQLPSAYLRQHCFVSVEPDEPYLPDVVRHLPEDRLVFGSDFPHLDHGEDVLGAMLSLRDVMTESRLRKVLWENPTRFYGVEP

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Crispr_ID: NC_017030_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_18

6369436-6369518

Orphan

Consensus_repeat	Method
TCCAGATACGGAGACGCCACGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_18

>merge|NC_017030|18|6369436-6369518|CRISPRCasFinder
TCCAGATACGGAGACGCCACGTCGTACCGCTGATCCGAAGCGCCCGGTGCGCGCGGGACTTCCAGATACGGAGACGCCACGTC

>NC_017030|18|16|6369436-6369518|CRISPRCasFinder
TCCAGATACGGAGACGCCACGTC	GTACCGCTGATCCGAAGCGCCCGGTGCGCGCGGGACT
TCCAGATACGGAGACGCCACGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014397848.1\|6354484_6355240_-\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|376576
NC_017030.1\|WP_043321831.1\|6362466_6364392_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_017030.1\|WP_014397867.1\|6384317_6385439_+\|DHH-family-phosphoesterase	unknown	unknown	gnl\|CDD\|223691
NC_017030.1\|WP_014397861.1\|6378661_6378889_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397860.1\|6373949_6378545_+\|response-regulator	unknown	unknown	gnl\|CDD\|274008
NC_017030.1\|WP_014397849.1\|6355403_6357998_-\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|235840
NC_017030.1\|WP_014397855.1\|6364452_6365046_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238870
NC_017030.1\|WP_014397864.1\|6381145_6382483_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223679
NC_017030.1\|WP_014397866.1\|6383470_6384304_+\|deoxyribonuclease-IV	unknown	unknown	gnl\|CDD\|179214
NC_017030.1\|WP_043321829.1\|6360533_6361409_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|188247
NC_017030.1\|WP_014397853.1\|6361491_6362250_-\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|376831
NC_017030.1\|WP_014397865.1\|6382603_6383443_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|376885
NC_017030.1\|WP_043321833.1\|6366711_6368301_-\|DUF1957-domain-containing-protein	unknown	unknown	gnl\|CDD\|212104
NC_017030.1\|WP_014397851.1\|6359293_6360508_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_017030.1\|WP_014397868.1\|6385435_6386581_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_017030.1\|WP_014397850.1\|6358021_6359152_-\|DNA-processing-protein-DprA	unknown	unknown	gnl\|CDD\|376794
NC_017030.1\|WP_014397863.1\|6380135_6381086_+\|branched-chain-amino-acid-transaminase	unknown	unknown	gnl\|CDD\|235841
NC_017030.1\|WP_148282604.1\|6371111_6373850_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340825
NC_017030.1\|WP_014397862.1\|6379079_6380021_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_017030.1\|WP_014397856.1\|6365110_6366610_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014397848.1\|6354484_6355240_-\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|376576	pfam01618, MotA_ExbB, MotA/TolQ/ExbB proton channel family. This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels. MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller. ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.	5.39088e-20
NC_017030.1\|WP_043321831.1\|6362466_6364392_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.48377e-60
NC_017030.1\|WP_014397867.1\|6384317_6385439_+\|DHH-family-phosphoesterase	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	1.14259e-46
NC_017030.1\|WP_014397860.1\|6373949_6378545_+\|response-regulator	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.11534e-25
NC_017030.1\|WP_014397849.1\|6355403_6357998_-\|type-I-DNA-topoisomerase	gnl\|CDD\|235840	PRK06599, PRK06599, DNA topoisomerase I; Validated.	0
NC_017030.1\|WP_014397855.1\|6364452_6365046_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238870	cd01832, SGNH_hydrolase_like_1, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.	1.44405e-44
NC_017030.1\|WP_014397864.1\|6381145_6382483_+\|AAA-family-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	6.40552e-10
NC_017030.1\|WP_014397866.1\|6383470_6384304_+\|deoxyribonuclease-IV	gnl\|CDD\|179214	PRK01060, PRK01060, endonuclease IV; Provisional.	1.1891e-105
NC_017030.1\|WP_043321829.1\|6360533_6361409_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|188247	TIGR02795, Uncharacterized_protein_in_oprL_3'region, tol-pal system protein YbgF. Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.	1.39824e-20
NC_017030.1\|WP_014397853.1\|6361491_6362250_-\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|376831	pfam02578, Cu-oxidase_4, Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.	3.47115e-86
NC_017030.1\|WP_014397865.1\|6382603_6383443_+\|Fic-family-protein	gnl\|CDD\|376885	pfam02661, Fic, Fic/DOC family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.	1.22408e-09
NC_017030.1\|WP_043321833.1\|6366711_6368301_-\|DUF1957-domain-containing-protein	gnl\|CDD\|212104	cd10792, GH57N_AmyC_like, N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins. Alpha-amylases (alpha-1,4-glucan-4-glucanohydrolases, EC 3.2.1.1) play essential roles in alpha-glucan metabolism by catalyzing the hydrolysis of polysaccharides such as amylose starch, and beta-limit dextrin. This subfamily is represented by a novel alpha-amylase (AmyC) encoded by hyperthermophilic organism Thermotoga maritime ORF tm1438, and its prokaryotic homologs. AmyC functions as a homotetramer and shows thermostable amylolytic activity. It is strongly inhibited by acarbose. AmyC is composed of a N-terminal catalytic domain, containing a distorted TIM-barrel structure with a characteristic (beta/alpha)7 fold motif, and two additional less conserved domains. There are other two canonical alpha-amylases encoded from T. maritime that lack the sequence similarity to AmyC, and belong to a different superfamily.	0
NC_017030.1\|WP_014397851.1\|6359293_6360508_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	2.31985e-07
NC_017030.1\|WP_014397868.1\|6385435_6386581_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	2.12326e-162
NC_017030.1\|WP_014397850.1\|6358021_6359152_-\|DNA-processing-protein-DprA	gnl\|CDD\|376794	pfam02481, DNA_processg_A, DNA recombination-mediator protein A. The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyze the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation.	2.82801e-73
NC_017030.1\|WP_014397863.1\|6380135_6381086_+\|branched-chain-amino-acid-transaminase	gnl\|CDD\|235841	PRK06606, PRK06606, branched-chain amino acid transaminase.	3.95407e-176
NC_017030.1\|WP_148282604.1\|6371111_6373850_+\|glycosyltransferase	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	1.17905e-43
NC_017030.1\|WP_014397862.1\|6379079_6380021_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.7715e-41
NC_017030.1\|WP_014397856.1\|6365110_6366610_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.08869e-152

>NC_017030.1|WP_043321833.1|6366711_6368301_-|DUF1957-domain-containing-protein
MSLGSLALVLHAHLPFVRHPEYEDFLEEDWLYEAISETYLPLLRVFDRLVEDRVPFRVTMTLSPTLVSMLNDELLRERYARRLDSLCELGAREVHRTRDDPTFHPLAVFHRDHFESLRLAYHNHYRRDLVAAFRRLQDSGHLDILTCNATHGFLPLMQQTPEAVRAQVTVAANHYRQNFGRDPAGIWLAECGYYPGLERILSAERIRYFFADTHALTDATPRPLHGPYAPIFTEPGVAAFARDPESSQQVWSTEHGYPGDPVYREFYRDIGWDLDLDYIRPFIQPTGDRKNTGFKYFRITGKTNDKQPYDPAAARERAWVHAGNFLFNRERQFEYLASRMGGRKPVVVAPYDAELFGHWWFEGPHFIDALIRQAARNPSRFTLISPLDDLREHPENQVATPPMSSWGAGGYANMWLDGTNDWIYRHLNHAARQMVELARDFPDAPSLKRRALNQAARELLLAQASDWAFIMKTGTMVDYAVRRTKEHLQRFLRLHDQVRAGTVDESWLSHVEGRNNLFPELDYRVYRPG
>NC_017030.1|WP_014397856.1|6365110_6366610_-|trypsin-like-peptidase-domain-containing-protein
MTHTLPPFRRKLVAAVLVLASPTLALAQAPAPQPPAPKTQQAASGQAGNLQPATREAQSLASLAPLVESVKSAVVNVDVQARPEMPEGMEDNPLFDRFFGGNGRGRGGRSEREQIRQGAGSGFIIDPKGLVLTNNHVIEDAVTITIRLDDGRSFTGEVVGRDPLTDVAVVKIKEKVDQLPSVKLGDSDAVRVGDWVLAIGNPFGLASSVSVGILSARAREIGASVYDDFLQTDAAINPGNSGGPLFNMKGEVVGINTAIVGGGTGIGFSVPSNLIKALLPQLEKEGAVTRGWLGVGIQPLTRELGQALKLSVSEGAILTQITPDSPAAKAGLKPDDVVVAVDGKQVRSDSELTRTVALKKPNSVATLTLYRDGKKQDVKVTMGTRPDLEGLSKKKPGATDEQDSSRRVGVSLQDLDARTASQAGFTERAGALITDIVPGSPADRAQLTPGMLVVEANKKPIASAKELAAAIRAAPKGSTLLLRVAGPGGGRLLRALTVP
>NC_017030.1|WP_014397855.1|6364452_6365046_-|SGNH/GDSL-hydrolase-family-protein
MSVNYVSLGDSTAVGVGASQGGGYPDRLASRLRKGGLPVGHTNLGQSGARVRDIVNNALKRVIALQPTLITLGVGTNDIWRGTEVAEFQDDLDRIARRLKQTGASMVVVNLADMALAPVAKMVPSALYEGRIEQFNDAIASVARSHGLHLVDLYTASREMIPRRPDFFCSDGFHPSAEGYEEWADLMLPVVRTLVRR
>NC_017030.1|WP_043321831.1|6362466_6364392_+|diguanylate-cyclase
MALGSETIGRKLLWSIALPGLVVALLGVGHFSREARQAVREGTHLEALALAEAVASTFTLPQAPGAAPHGAVAEVLASDTRLFRSVEDLRVLTPEGRIRWSRRPAEQGHPHPEASRLSATGPETARSSDHGTEVVRPLGGPECSGCHTGEAAQRMGVLQVRMGEPALTRQLQTVFQDALGAMVLFVGILGLVTWLSLRFVLTAPLKRLSEAMGRAADGDLLVRAEARGTDEISRLGAAFNQMLARLTSMKVEEIDTHRDLQLVKEKLALKDELEERLTELSLLFDVARSLNTTLELDELLSRITRMVVERLHIPDFSIMLLNEEGLLEVKHAWPQGRGLEGHTFAMGEGACGRAAQARKAVYLPDLTDSTSVFARRGLRGGSEQGSLLAVPMVHADTLLGVINFQRPETASISAEEIELFTAVADQAATAVTNARLHAETVKLTLTDALTGVPNRRHLFQRMDLELARAQRFGVPMALLMVDVDHFKRLNDLAGHRAGDETLRRVSDVLRNRARKVDTLGRYGGEEFVLLLPQVSKATAVEVAETLRRAVADSVTLSRPGLPGGHVTVSIGVAHFPTDATSQDMLVDCADSALYCSKRTGRNRVTAFEPGMEVHPGRERSISTPPADAPSTPPAPSGIAKA
>NC_017030.1|WP_014397853.1|6361491_6362250_-|peptidoglycan-editing-factor-PgeF
MTPPVFLTSELLPVPHGFATRAGGVSEGPYASLNLGFSVNDERSRVEENHRLLARAAGARLGALCRVSQVHGDRVLEARGESDDVLRPTLGEADALWTEGEGSWVAVGTADCVPVLIVDPRGKRVAAVHSGWKGTDLEISARTVETLVARGSRPEDLLAAVGPCIQACCYEVSPELGDRFRARFGPDVVRAGDKPHLDLPRAVKASLLKAGLTPEHVDVLQACTACDPDRFFSHRRDAGRTGRHLNYVLHRF
>NC_017030.1|WP_043321829.1|6360533_6361409_-|tetratricopeptide-repeat-protein
MPVRPFLFRLFAAVALSAPTACATTAASQSEVGRLEAEVRTLRASQASLLERLERLENRDAVSRARAATPAPAAASPKATASTKPEAASPEGGEALSLAPAELTVVRLKPKKEPAPRINTAVAVVEPDSDQMEMFISPVEGSNGTGSVGSISASTAARMEPPEKDPDILDAEYERAVAMLRTGNVEGGVETLTRFAAENPRHPRADNALYFSGLGQMGLKDAAGAAKTFEKLIKNYPAGDAVQDGMLRLAECRVRLNQAVDARALYTRVVTQFPGTAAATQAEQRLAALSP
>NC_017030.1|WP_014397851.1|6359293_6360508_-|LysM-peptidoglycan-binding-domain-containing-protein
MRSRILASLLVPLTVAPAWTAFAQDAQEEEPQPASETEGQDISDDVEQRPTSVTLPPGAAQGRESAPGQVHTVETGDTLWDLSQRYLGSPWYWPKVWSYNPQIANPHWIYPGNNVKFFPGGEEVPARVEGGDLPSDDVAAPTDVSGGSLVSVVGKIGYDPSKSSPVTTKGFVTTRELDEAGRIEGSTSEALMLSAPEKVYLRFKKRGAAKIGDRYVIFHTVEEVKHPVTNARTGYLTELLGTVQVVSINNDVVTARIMETWDPISRGDLVGPSSEKLSERISPKPNSKEIPGFVLTPMTPGQTLLGEHNFVVVDRGTADGVQVGNTFTIERRGDPSLDVLGRSDYKMGDAGKGQKTYPWEAVAQCMVTEVRERTSNCLMTRSMVEVSAGDRATMRKDGTPTASR
>NC_017030.1|WP_014397850.1|6358021_6359152_-|DNA-processing-protein-DprA
MADTNTDTHLHWDEQRATLALWAIAGLGPRTLDAVRAFAGGALSRLAAVPVRDWVADVPVPATVRQRLAAVASLDALASRTEEACAQSGLQVAFAGSPPYPSRLVGLEDAPPLLFYLGHPGPPRRRLAMVGSRHPDQGFLPFARTFARKVAEAGVGVVSGAAEGVDRACHWGALDVGAETWAFLGSALDALDPAQARLLPHFLERGGVYFSELPPGVRASTTTFPRRNRLISGASDAVLVMRAGEGSGALYTAEAAQAQGRPVFALPGDVWQPAAAGCNALLADGRARACTSAESICAVVGVHPVRAVPAGRDAGWWEALSAEARGAYGLLDRAPRSFDEVLAASPLSPAALTSALVELELSGLVVQHPGKRYEKV
>NC_017030.1|WP_014397849.1|6355403_6357998_-|type-I-DNA-topoisomerase
MATRKKTQAAQTEAAAEETPKKAAAKKPAAKKAAKKKTAAKKVTAKKKTAARRRGADADELPTVDADADAEEEVPERRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKIGVDVEDDFKPEYTVIKGKEKVLNELKKMAKTVDRVFLATDPDREGEAIAWHIKEELGHPDSLRVTFNEITKRAVQDAIAQPRELNQDNYDSQQTRRILDRLVGYQISPLLWKKIRRGLSAGRVQSVAVRLIVEREAEIKAFQPEEYWTLDALVQGPQGPPPFKAKLSRVDGKKVELKDRATTDGLVAELKDAPFTVTKVDRKERRRNAPAPFITSKLQQEAANRLHFTAKKTMTLAQKLYEGVPLGEEGQTALITYMRTDSTRLSDDAVTQVREFIGQKYGADYLPAEPMVYKSRKSAQDAHEAIRPTSLEYPPERVRPFFDAMDELDMFRLYELIWNRFVACQMKPAVYDQTAADITAGRATFRASGSTLKFPGYLGVYGAGLTPEEEAAAEKAKAAGEEGAEDVVGELPPLNEGEVLTLDKLLNEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSNIQDKKYVEKLESRFRPTDLGQMTNELLVKHFPHELDVSFTASMEEKLDQISDGGASWKTVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIACEKCGNPFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVIVEEETTDEKCEKCGKPMVIKRGRFGRFMACSGYPDCKTSKPISIGVNCPECKVGYLTERRSGRGKIFFGCNRYPECKFAAWDRPLAEQCPQCASPYLLQKFSKRDGAYIACPNKECDYRREVVEPAIPGASAEGAPAPTPTVEA
>NC_017030.1|WP_014397848.1|6354484_6355240_-|MotA/TolQ/ExbB-proton-channel-family-protein
MIPSVSELLRVVVAEAAPAAAGHASSGGLGDFIVGAFKAGGPFMFVNLFWLAASLAVIGERAVTLLFRYRLNATAFIEQVHKMVRSGNLDRAVKFCGMAPRSPLARVIRAGLINANRGELEVAKAVEEAMAEYTPHVSRRVQWLWSLANIATLVGLVGTIVGLIGTFRALGNVPAEQKQALLSNGISEAMYNTGFGLSIAVLCIVAHLFFSNYAKNMVELVELNALKLENLLSRRGSLEVVPSDSDVRAAS
>NC_017030.1|WP_148282604.1|6371111_6373850_+|glycosyltransferase
MPGPSGSSRRLTEYLKALPDRFSVVVLSAKTPDHSHIEKYQGARLLRVPVGSGDLASRIQSFERAVRRQLESEDYALAHFTDPFGGYALCELKADYGYRLIYEAQTFPSQELRYTHPQTDGDRRFLSKIRRQELFCLMNADLVVTGSQTTRAFIQGLGAAEDQLRTIRAPVDLKPYDPEVLGAPDGSPLRMMYLGSHVGWQGLPTLLRATALAAQQVDVRLTLVGAHHPDWKPHLEDLVNDLGIKEKVDFQPPVAHDDLVKVLALADVGVLPLDDSERNRLQGGPLAKVSEYLAAGRPVIAADLPVTRELIPKDAAIFFPPGDSRALSERILDLARDVPRRVALGKAGRAFAEKVLDAGLIRGQLLDLYDSLLEKRGHGPVEAASEPPDVTMTGTPTNRLASLGMPEASQPAPAPKPPAKPAVQAASDEADPPPTKEGPEDAPVVMGMALDDGMDTRLVKTEPDMRPDEVPMVMGLPLRESATAAPAPAGREATPPPEPEAAPQTTDDTAKTTLPSSPAKDGEPEPLGGRGSEPAPPTEMVTSPLVKALGLKELSRDDAGDSDAEARASEDGSSGATAVVRRPVEVEEDDSSTPAPTPVVRRPASEDEAPAPTPVVRRPLPEDEPPAATPIVRRPTSLSEDEERAPTPVVRRTGVMREEEEAPAPTPIVPMRSLLTGARSTSASRAQRPQDSTPSEPPRLFPTPSPMADAEKPPIRGGLAADPGRPASRPPVLAESDKPPIRGGSVSDADRPPQLPPRAAAPPPVPRQGPPRLSPTPPVLKPSVSSDDEPEEIAADEAQSLDDDAGNTPSNASAALDEAEEIAADEVHDADALEVEAADAEEAVDEGPPPAPPDSTLNPWFAQLAHGYCPPEGARFARHTPPTNFPGRDPEEGVPPGSVPPVGQGAVRGKNS
>NC_017030.1|WP_014397860.1|6373949_6378545_+|response-regulator
MERRVLIVESQNDFALSMASVLKSAGYNTAMATTASDAQRELEKRRPDLVVVRAELPDQSGFALCGQIKKGKWGQNLKVLLLSSDSGVEGLNKHRETPAAADGYLVIPFEMGELASMSAGIVPPGSDESDADLDAALSGAPREAPPPMPGVRTGAPPKLPKRERRSAMTDEDKAFMDRAFSSIADRKAELLAESRQLKRPPPRRELMGTPEGKIQILRDELKTREAQLARLSEIWSVRERELLSVEDRLHEKDVELQGLKMQVDDLLRRFNDAQQSIVQKEREHGATVDDLLLQKFSSEKDLIEVVASKEKDINVLRKEVNLRDEELSRRGADLESWRNEFDKLEKHLGVVTLEFEVKEQKLQDTVRANEADILQLRERGDQFESELSRTVSERDQRYAELDGELQALQERLTQTEQERDATVRGLEARATTAEEHASRSDAEIERLNAERAALEQRLNQQVADLESDIARVTGERDQLRLDKDALEADLTQRVEEREAKISALDRELQETIARNENSEAELNATIQQHRERIGELEGEVEAVKTHLEDRENELNAEIQALQQAKDALEQDLTSQLEDLRAAKDALEADLNGQIQALTEQLDAAQRQGEQLSARVASLEDTVAQRDGTIEGLQTDVSDRDSRIAELTGNLEATSQQLSETQNTLSSTEATLAETRGELEATSQQLSETQGTLSNTEATLSETRGELEATSQQLSETQTRLAQTEETLSTTRGELEATSQTLATTEATLADTQGTLARTEATLSDTQAPSPSTEGTLAETRGELEATSQTLSDTQARLAQTEETLSTTRGELEATSQTLSDTQATLSSTEGTLSETRGELEATSQTLTETQARLAQTEGTLASTQGELEATSQTLATTESTLAQTQDTLARTEATLADTQATLSSTEGTLAETRGELEATSQTLTQTQETLESTRADLAKVTQHRDELDAELHETRDLLQETNGLLARTTEERDARIADLQALNAAKDALEQDLTGQIGQLRADLSETQGLYDAERTAHAALAEETTARINALTGERDNLTAELNATSQQLADTQGQLASTQDALAREEQAHAQSRQAAASMQAELTRQLTEAQANGEDLAEQLIVTKHELGTRVSEVTQLSSTLAQTEDARHHLEDRLQTLTHESQRREELLQNEVDTKGKELSDTLRKLTHVTQEKMRQAEVLNREVTTRTEQVKQLEGQLEHQASEAKKQADALNQQLANVSGELDGARKAIADRDGQLQQAANQQKKLTSERDGLAGQLQQAQAQAQQQAQQAQAAAAEAKKQSDDLAAKLAKADQRIAQLSQEAQKFAADTEAKLKDAQAQLQARTKKAQDLELALENAQSTRARAEKDLNARVAAAETKANEAAARLATAQKERKDLEARQAKELEDLNAKQKAELERREAIKAQEVARLQTSVQEKSKALKVAELELARYKTKAPAAAAPAAKAGAKASEEEHLAATVQANPVIPAAAKPPAKAAGKPAAKKAAAAPTPVPVDEEAPERTMVMQLPTAPEAGEDDWTALVDELDK
>NC_017030.1|WP_014397861.1|6378661_6378889_-|hypothetical-protein
MWAWLKLAMAVLVVVMPGGFPLVLAYIATRTLLERWRVAQAQAREEGRPVSVVRDVVGALHFRDLIREARAATAL
>NC_017030.1|WP_014397862.1|6379079_6380021_+|MoxR-family-ATPase
MSPPQLTSEIRSFTSVEDAARRLEAVGYLSSPEIATAVFLADRMGKPILVEGPAGVGKTELAKALAQALDRTFLRLQCYEGLDEAKALYEWEYAKQLLYTQLLKDKIGELTQGTSTLAEAADRLASGDAVFFSERFLLPRPILQAQLSDTPALLLVDEIDKADPEFEAFLLEVLSDNAVTVPELGTIRAKHVPRVILTSNNARELSDALKRRCLHLHIDFPDRERELRIVRSRLPEVPQVLAEQVVEAVAAIRALDLKKAPSISETLDWAQSLALLNAEALSADIVAATLNLVLKYEGDIEKARANLPTIAQA
>NC_017030.1|WP_014397863.1|6380135_6381086_+|branched-chain-amino-acid-transaminase
MSSTSSTVLRAEHIWLDGKLMKWDEGNVHVMTHALHYGLGVFEGIRAYKTHDGRLAVFRLREHIRRLLDSAHIIMLQIPYSEDELVEATVDLLRKQKQQFANGAYLRPVAFMGDGAMGLGAVNPTRVGITAWDWGAYLGDKGIKEGIRAKVSSFTRNHVNVNMVRGKITGQYVNSILAKREAVLAGYDEAILLDISGFVAEASGENIFLVNKKGVIKTPPLSSPVLDGITRDTVLKLLRDAGHTTIEEVTVTRDALYIANEVFFTGTAAEITPVREVDNRQIGDGKPGPISKYVQDTYFRVVRGQEARYADWLTYV
>NC_017030.1|WP_014397864.1|6381145_6382483_+|AAA-family-ATPase
MPPAGYAYEDNPFKLENPSVLDIAPGEPKSLEDTGLRMGLLADLGLKFLYYAGTGTGVAIAESMCLPWSGVVEHVVDFLAAEKLVDLRGGKGFGRASVEFALTEKGREYARDALTRSTYVGPAPVPIEQYNALISSQTEETPVVGQEDLVAALGHLTVSAELMDKLGPAVNSGRSLFLYGPPGNGKTSLAEAISHMFGGEVFVPHCLEIDNQIIKVFDRIIHTPVPLEMGRDANGRRQTFEMDKRWSLCRRPAVVVGGELTLETLDLIYSESTRFYEAPFQVKANGGMLLIDDFGRQKVHPTDLLNRWIVPLEKRVDFLTLHTGKKFEIPFDQLLVFSTNLDPKELVDEAFLRRIKYKIEVGNPDEESYREIFRRVCEAAGIPYVDQAITYLVEHYYKPRSMEMRSCHPRDLVSLIRDAARYRQIPPALSKDLLDQACEVFLVNL
>NC_017030.1|WP_014397865.1|6382603_6383443_+|Fic-family-protein
MKERYQDIDEKNEQLREYLEIYKGKPPAREYLDRFEMSWIYHDAALEGVVYTHQELMAALFPERTAAEASMIPVVLEIRNHKAVADFIREEAAGAKKQSALTLTTIKRMHDLFLGNTPEALAERARMERRERTEKELAKERDRAGLRKDMPLHRTYFHDITQPAKIQARLEKLVDHTASAEFREFHPIKQAAVVQHEFLQIFPFTEHSGKVGRMCSNLILLRNGYMPAVIHSIDRQRYYESFRAPVATFRTVLMDAMENSLDNGVKYFRDLGRKYKTVE
>NC_017030.1|WP_014397866.1|6383470_6384304_+|deoxyribonuclease-IV
MRIGAHESIAGGVSQAFQRAEAHGARALQIFTKNARGWSAPALTDAETEAFRAEARRTGLPVIAHGSYLVNLAGEAPEAREKSLACVTEELTRCERLGIPLLILHPGSHPDEARGLRLIAEGLDEVHRRCPGYTARVCLEMTAGQGSALGWRFEHLEELLSRVADEARLAVCLDTCHLFAAGYDLRTPKGYAAVMDECDRRVGLHRVRAFHLNDCKKPLGCRVDRHEEPGKGAIGLTAFRCLMKDARFVDTIGVLETPFPERYGENIRLLESLCRRK
>NC_017030.1|WP_014397867.1|6384317_6385439_+|DHH-family-phosphoesterase
MPVTPSLQSRRAQLPAGSELTEPPPARLAKLPAADKLARLLQVAKGHRRALILTHDNPDPDSMAAAVSLAHLLERKAGIEAHVGYGGIIGRAENVAFVRVLRLPVSHVSQIDFSQYDLFGLVDTQPPVRNHSLPARYRADLVVDHHPLREESLLAPFADVGGDFGATSTMLVEYLRAARLEPSVEIATALFYGIKADTRDLGRETTQTDVDSYLWLFPRCDKQLLGQIEHPELPARFFQLFHTSIEKAKVYGTAIITDLEEVYSPDLVAEVAERMMYLEGMKWSLAYGTYRNQLFLSLRVKDRRMNAGRLIRELCDDLGGSSGGHGSMAGARLPLSGSASKRKALKREVVSRFLEAFGVSEERPVSLLSAQDT
>NC_017030.1|WP_014397868.1|6385435_6386581_+|cysteine-desulfurase
MIYWDHNAAAPVRAEVGALLARAFTEGGFGNASSVHGGGREARARLDAARAKVARVLGCEPKEITFTASGSEADALALVGAYAARPVKDRRRVVSTTVEHPSALGALAQLEKDGAQVVRLSPDASGRVPLEAVLEALTPDTALCSLMWANNETGVLQPVAETARACRQRGILFHTDAVQAAGKVPLTLREVDADLLSLSAHKFGGPQGVGVLVVRKGVDVRALTPGHQEGGRRGGTQNVPHAEALALALELAAADQASTAARVAALRDTFEQQVLQRLPGVTVNGAGAPRVPNTSNLRFDGVEGEALLMALDLEDIRVSSGAACASGTLSPSHVLRAMGLSPAEARSSLRFSLGPGTTSAEVTRVVDALCTHVPRVRALGG

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Crispr_ID: NC_017030_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_20

6373473-6373590

Orphan

Consensus_repeat	Method
GACGAGCCGGAGGAGATCGCCGCCGACGAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_20

>merge|NC_017030|20|6373473-6373590|CRISPRCasFinder
GACGAGCCGGAGGAGATCGCCGCCGACGAGGCCCAGTCCCTGGACGACGACGCCGGCAACACGCCCTCCAACGCCAGCGCGGCGCTGGACGAGGCGGAGGAGATCGCCGCCGACGAGG

>NC_017030|20|17|6373473-6373590|CRISPRCasFinder
GACGAGCCGGAGGAGATCGCCGCCGACGAGG	CCCAGTCCCTGGACGACGACGCCGGCAACACGCCCTCCAACGCCAGCGCGGCGCTG
GACGAGGCGGAGGAGATCGCCGCCGACGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_043321831.1\|6362466_6364392_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_017030.1\|WP_014397867.1\|6384317_6385439_+\|DHH-family-phosphoesterase	unknown	unknown	gnl\|CDD\|223691
NC_017030.1\|WP_014397861.1\|6378661_6378889_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397860.1\|6373949_6378545_+\|response-regulator	unknown	unknown	gnl\|CDD\|274008
NC_017030.1\|WP_014397849.1\|6355403_6357998_-\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|235840
NC_017030.1\|WP_014397855.1\|6364452_6365046_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238870
NC_017030.1\|WP_014397864.1\|6381145_6382483_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223679
NC_017030.1\|WP_014397866.1\|6383470_6384304_+\|deoxyribonuclease-IV	unknown	unknown	gnl\|CDD\|179214
NC_017030.1\|WP_043321829.1\|6360533_6361409_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|188247
NC_017030.1\|WP_014397869.1\|6386596_6386770_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397853.1\|6361491_6362250_-\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|376831
NC_017030.1\|WP_014397865.1\|6382603_6383443_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|376885
NC_017030.1\|WP_043321833.1\|6366711_6368301_-\|DUF1957-domain-containing-protein	unknown	unknown	gnl\|CDD\|212104
NC_017030.1\|WP_014397851.1\|6359293_6360508_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_017030.1\|WP_014397868.1\|6385435_6386581_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_017030.1\|WP_014397850.1\|6358021_6359152_-\|DNA-processing-protein-DprA	unknown	unknown	gnl\|CDD\|376794
NC_017030.1\|WP_014397863.1\|6380135_6381086_+\|branched-chain-amino-acid-transaminase	unknown	unknown	gnl\|CDD\|235841
NC_017030.1\|WP_014397862.1\|6379079_6380021_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_017030.1\|WP_014397856.1\|6365110_6366610_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NC_017030.1\|WP_014397858.1\|6368327_6370934_-\|DUF4912-domain-containing-protein	unknown	unknown	gnl\|CDD\|379808

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_043321831.1\|6362466_6364392_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.48377e-60
NC_017030.1\|WP_014397867.1\|6384317_6385439_+\|DHH-family-phosphoesterase	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	1.14259e-46
NC_017030.1\|WP_014397860.1\|6373949_6378545_+\|response-regulator	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.11534e-25
NC_017030.1\|WP_014397849.1\|6355403_6357998_-\|type-I-DNA-topoisomerase	gnl\|CDD\|235840	PRK06599, PRK06599, DNA topoisomerase I; Validated.	0
NC_017030.1\|WP_014397855.1\|6364452_6365046_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238870	cd01832, SGNH_hydrolase_like_1, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.	1.44405e-44
NC_017030.1\|WP_014397864.1\|6381145_6382483_+\|AAA-family-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	6.40552e-10
NC_017030.1\|WP_014397866.1\|6383470_6384304_+\|deoxyribonuclease-IV	gnl\|CDD\|179214	PRK01060, PRK01060, endonuclease IV; Provisional.	1.1891e-105
NC_017030.1\|WP_043321829.1\|6360533_6361409_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|188247	TIGR02795, Uncharacterized_protein_in_oprL_3'region, tol-pal system protein YbgF. Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.	1.39824e-20
NC_017030.1\|WP_014397853.1\|6361491_6362250_-\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|376831	pfam02578, Cu-oxidase_4, Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.	3.47115e-86
NC_017030.1\|WP_014397865.1\|6382603_6383443_+\|Fic-family-protein	gnl\|CDD\|376885	pfam02661, Fic, Fic/DOC family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.	1.22408e-09
NC_017030.1\|WP_043321833.1\|6366711_6368301_-\|DUF1957-domain-containing-protein	gnl\|CDD\|212104	cd10792, GH57N_AmyC_like, N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins. Alpha-amylases (alpha-1,4-glucan-4-glucanohydrolases, EC 3.2.1.1) play essential roles in alpha-glucan metabolism by catalyzing the hydrolysis of polysaccharides such as amylose starch, and beta-limit dextrin. This subfamily is represented by a novel alpha-amylase (AmyC) encoded by hyperthermophilic organism Thermotoga maritime ORF tm1438, and its prokaryotic homologs. AmyC functions as a homotetramer and shows thermostable amylolytic activity. It is strongly inhibited by acarbose. AmyC is composed of a N-terminal catalytic domain, containing a distorted TIM-barrel structure with a characteristic (beta/alpha)7 fold motif, and two additional less conserved domains. There are other two canonical alpha-amylases encoded from T. maritime that lack the sequence similarity to AmyC, and belong to a different superfamily.	0
NC_017030.1\|WP_014397851.1\|6359293_6360508_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	2.31985e-07
NC_017030.1\|WP_014397868.1\|6385435_6386581_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	2.12326e-162
NC_017030.1\|WP_014397850.1\|6358021_6359152_-\|DNA-processing-protein-DprA	gnl\|CDD\|376794	pfam02481, DNA_processg_A, DNA recombination-mediator protein A. The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyze the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation.	2.82801e-73
NC_017030.1\|WP_014397863.1\|6380135_6381086_+\|branched-chain-amino-acid-transaminase	gnl\|CDD\|235841	PRK06606, PRK06606, branched-chain amino acid transaminase.	3.95407e-176
NC_017030.1\|WP_014397862.1\|6379079_6380021_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.7715e-41
NC_017030.1\|WP_014397856.1\|6365110_6366610_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.08869e-152
NC_017030.1\|WP_014397858.1\|6368327_6370934_-\|DUF4912-domain-containing-protein	gnl\|CDD\|379808	pfam16258, DUF4912, Domain of unknown function (DUF4912). This family consists of uncharacterized proteins around 160 residues in length and is mainly found in various Clostridium species. The function of this family is unknown.	1.72535e-29

>NC_017030.1|WP_014397858.1|6368327_6370934_-|DUF4912-domain-containing-protein
MDERKGVTVSYLRQLARKYLREGAGASRGRELVSSLAERIPALGRLARMAGLATSRRGSGDVGGEEKALDSGPADSRDAKGPASESVPLPPPESAAAPQARELSEEPITQPGSGPRTRPARVVTFPARVKARRDPDEEDTQPLSPEAPTPRPSSSPKGDSPAAAKPAPASEPPHAAEPLVEGFFVTKMAGEKEARRHHLLEEQAPRLPPADASPERDEHLAMLPLDYQDDAMVLLARDPHTLFVFWDFSDASRNRALDELPAPRAVLKVFDGEGVSREVDFALESRSFYLQGMTPGRTYRVEAHFVGSDGRSRRIGHSSNRATLPPAGPSADTSIRFLRMPPPPVVDRLREAVPSAASARVPRVEEREYVTWRRVQLPGSAGVVDVPEVHRERTEAYVDAPRVPGASDQRYVEEAYLESAPRAPGASDQQYARVGEATLGEGAVLAPSRAPGASDQRYLAVELAPGASDQRYDVASPYLEVPRAPGASDQRYDVASPYLEVPRAPAASDQRYGQAQLPGGVSEYRYLEVPRAPGASDQRYVAGGQGTSDQRYLSVPRAAEASDQRYLSVPRAAGASDQRYLTVPRAAGASDQQYLSVPRAAGASDQRYLSADRATGASDQQYLTVPRAAGASDQRYLSVDRATGASDQQYLTVPRAAGASDQRCLSADHATGTSDQPGASRTAGGSDAWSPESPRSRGDVTEARDLPSSPPVGTSAPVGAEASFPSGPSTQGTASTDSWRPTEPEPPKDPWALSVARGPSASEQRALDKAREAARRAALASVPVSPSPAKVEAPAAMPASTPPAKAEAPTAPTPKVESRAAPSAVAPKADAVKSPPAAPSKAAQNPPEPKPSGSKSSTRSRPSRRGRK
>NC_017030.1|WP_043321833.1|6366711_6368301_-|DUF1957-domain-containing-protein
MSLGSLALVLHAHLPFVRHPEYEDFLEEDWLYEAISETYLPLLRVFDRLVEDRVPFRVTMTLSPTLVSMLNDELLRERYARRLDSLCELGAREVHRTRDDPTFHPLAVFHRDHFESLRLAYHNHYRRDLVAAFRRLQDSGHLDILTCNATHGFLPLMQQTPEAVRAQVTVAANHYRQNFGRDPAGIWLAECGYYPGLERILSAERIRYFFADTHALTDATPRPLHGPYAPIFTEPGVAAFARDPESSQQVWSTEHGYPGDPVYREFYRDIGWDLDLDYIRPFIQPTGDRKNTGFKYFRITGKTNDKQPYDPAAARERAWVHAGNFLFNRERQFEYLASRMGGRKPVVVAPYDAELFGHWWFEGPHFIDALIRQAARNPSRFTLISPLDDLREHPENQVATPPMSSWGAGGYANMWLDGTNDWIYRHLNHAARQMVELARDFPDAPSLKRRALNQAARELLLAQASDWAFIMKTGTMVDYAVRRTKEHLQRFLRLHDQVRAGTVDESWLSHVEGRNNLFPELDYRVYRPG
>NC_017030.1|WP_014397856.1|6365110_6366610_-|trypsin-like-peptidase-domain-containing-protein
MTHTLPPFRRKLVAAVLVLASPTLALAQAPAPQPPAPKTQQAASGQAGNLQPATREAQSLASLAPLVESVKSAVVNVDVQARPEMPEGMEDNPLFDRFFGGNGRGRGGRSEREQIRQGAGSGFIIDPKGLVLTNNHVIEDAVTITIRLDDGRSFTGEVVGRDPLTDVAVVKIKEKVDQLPSVKLGDSDAVRVGDWVLAIGNPFGLASSVSVGILSARAREIGASVYDDFLQTDAAINPGNSGGPLFNMKGEVVGINTAIVGGGTGIGFSVPSNLIKALLPQLEKEGAVTRGWLGVGIQPLTRELGQALKLSVSEGAILTQITPDSPAAKAGLKPDDVVVAVDGKQVRSDSELTRTVALKKPNSVATLTLYRDGKKQDVKVTMGTRPDLEGLSKKKPGATDEQDSSRRVGVSLQDLDARTASQAGFTERAGALITDIVPGSPADRAQLTPGMLVVEANKKPIASAKELAAAIRAAPKGSTLLLRVAGPGGGRLLRALTVP
>NC_017030.1|WP_014397855.1|6364452_6365046_-|SGNH/GDSL-hydrolase-family-protein
MSVNYVSLGDSTAVGVGASQGGGYPDRLASRLRKGGLPVGHTNLGQSGARVRDIVNNALKRVIALQPTLITLGVGTNDIWRGTEVAEFQDDLDRIARRLKQTGASMVVVNLADMALAPVAKMVPSALYEGRIEQFNDAIASVARSHGLHLVDLYTASREMIPRRPDFFCSDGFHPSAEGYEEWADLMLPVVRTLVRR
>NC_017030.1|WP_043321831.1|6362466_6364392_+|diguanylate-cyclase
MALGSETIGRKLLWSIALPGLVVALLGVGHFSREARQAVREGTHLEALALAEAVASTFTLPQAPGAAPHGAVAEVLASDTRLFRSVEDLRVLTPEGRIRWSRRPAEQGHPHPEASRLSATGPETARSSDHGTEVVRPLGGPECSGCHTGEAAQRMGVLQVRMGEPALTRQLQTVFQDALGAMVLFVGILGLVTWLSLRFVLTAPLKRLSEAMGRAADGDLLVRAEARGTDEISRLGAAFNQMLARLTSMKVEEIDTHRDLQLVKEKLALKDELEERLTELSLLFDVARSLNTTLELDELLSRITRMVVERLHIPDFSIMLLNEEGLLEVKHAWPQGRGLEGHTFAMGEGACGRAAQARKAVYLPDLTDSTSVFARRGLRGGSEQGSLLAVPMVHADTLLGVINFQRPETASISAEEIELFTAVADQAATAVTNARLHAETVKLTLTDALTGVPNRRHLFQRMDLELARAQRFGVPMALLMVDVDHFKRLNDLAGHRAGDETLRRVSDVLRNRARKVDTLGRYGGEEFVLLLPQVSKATAVEVAETLRRAVADSVTLSRPGLPGGHVTVSIGVAHFPTDATSQDMLVDCADSALYCSKRTGRNRVTAFEPGMEVHPGRERSISTPPADAPSTPPAPSGIAKA
>NC_017030.1|WP_014397853.1|6361491_6362250_-|peptidoglycan-editing-factor-PgeF
MTPPVFLTSELLPVPHGFATRAGGVSEGPYASLNLGFSVNDERSRVEENHRLLARAAGARLGALCRVSQVHGDRVLEARGESDDVLRPTLGEADALWTEGEGSWVAVGTADCVPVLIVDPRGKRVAAVHSGWKGTDLEISARTVETLVARGSRPEDLLAAVGPCIQACCYEVSPELGDRFRARFGPDVVRAGDKPHLDLPRAVKASLLKAGLTPEHVDVLQACTACDPDRFFSHRRDAGRTGRHLNYVLHRF
>NC_017030.1|WP_043321829.1|6360533_6361409_-|tetratricopeptide-repeat-protein
MPVRPFLFRLFAAVALSAPTACATTAASQSEVGRLEAEVRTLRASQASLLERLERLENRDAVSRARAATPAPAAASPKATASTKPEAASPEGGEALSLAPAELTVVRLKPKKEPAPRINTAVAVVEPDSDQMEMFISPVEGSNGTGSVGSISASTAARMEPPEKDPDILDAEYERAVAMLRTGNVEGGVETLTRFAAENPRHPRADNALYFSGLGQMGLKDAAGAAKTFEKLIKNYPAGDAVQDGMLRLAECRVRLNQAVDARALYTRVVTQFPGTAAATQAEQRLAALSP
>NC_017030.1|WP_014397851.1|6359293_6360508_-|LysM-peptidoglycan-binding-domain-containing-protein
MRSRILASLLVPLTVAPAWTAFAQDAQEEEPQPASETEGQDISDDVEQRPTSVTLPPGAAQGRESAPGQVHTVETGDTLWDLSQRYLGSPWYWPKVWSYNPQIANPHWIYPGNNVKFFPGGEEVPARVEGGDLPSDDVAAPTDVSGGSLVSVVGKIGYDPSKSSPVTTKGFVTTRELDEAGRIEGSTSEALMLSAPEKVYLRFKKRGAAKIGDRYVIFHTVEEVKHPVTNARTGYLTELLGTVQVVSINNDVVTARIMETWDPISRGDLVGPSSEKLSERISPKPNSKEIPGFVLTPMTPGQTLLGEHNFVVVDRGTADGVQVGNTFTIERRGDPSLDVLGRSDYKMGDAGKGQKTYPWEAVAQCMVTEVRERTSNCLMTRSMVEVSAGDRATMRKDGTPTASR
>NC_017030.1|WP_014397850.1|6358021_6359152_-|DNA-processing-protein-DprA
MADTNTDTHLHWDEQRATLALWAIAGLGPRTLDAVRAFAGGALSRLAAVPVRDWVADVPVPATVRQRLAAVASLDALASRTEEACAQSGLQVAFAGSPPYPSRLVGLEDAPPLLFYLGHPGPPRRRLAMVGSRHPDQGFLPFARTFARKVAEAGVGVVSGAAEGVDRACHWGALDVGAETWAFLGSALDALDPAQARLLPHFLERGGVYFSELPPGVRASTTTFPRRNRLISGASDAVLVMRAGEGSGALYTAEAAQAQGRPVFALPGDVWQPAAAGCNALLADGRARACTSAESICAVVGVHPVRAVPAGRDAGWWEALSAEARGAYGLLDRAPRSFDEVLAASPLSPAALTSALVELELSGLVVQHPGKRYEKV
>NC_017030.1|WP_014397849.1|6355403_6357998_-|type-I-DNA-topoisomerase
MATRKKTQAAQTEAAAEETPKKAAAKKPAAKKAAKKKTAAKKVTAKKKTAARRRGADADELPTVDADADAEEEVPERRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKIGVDVEDDFKPEYTVIKGKEKVLNELKKMAKTVDRVFLATDPDREGEAIAWHIKEELGHPDSLRVTFNEITKRAVQDAIAQPRELNQDNYDSQQTRRILDRLVGYQISPLLWKKIRRGLSAGRVQSVAVRLIVEREAEIKAFQPEEYWTLDALVQGPQGPPPFKAKLSRVDGKKVELKDRATTDGLVAELKDAPFTVTKVDRKERRRNAPAPFITSKLQQEAANRLHFTAKKTMTLAQKLYEGVPLGEEGQTALITYMRTDSTRLSDDAVTQVREFIGQKYGADYLPAEPMVYKSRKSAQDAHEAIRPTSLEYPPERVRPFFDAMDELDMFRLYELIWNRFVACQMKPAVYDQTAADITAGRATFRASGSTLKFPGYLGVYGAGLTPEEEAAAEKAKAAGEEGAEDVVGELPPLNEGEVLTLDKLLNEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSNIQDKKYVEKLESRFRPTDLGQMTNELLVKHFPHELDVSFTASMEEKLDQISDGGASWKTVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIACEKCGNPFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVIVEEETTDEKCEKCGKPMVIKRGRFGRFMACSGYPDCKTSKPISIGVNCPECKVGYLTERRSGRGKIFFGCNRYPECKFAAWDRPLAEQCPQCASPYLLQKFSKRDGAYIACPNKECDYRREVVEPAIPGASAEGAPAPTPTVEA
>NC_017030.1|WP_014397860.1|6373949_6378545_+|response-regulator
MERRVLIVESQNDFALSMASVLKSAGYNTAMATTASDAQRELEKRRPDLVVVRAELPDQSGFALCGQIKKGKWGQNLKVLLLSSDSGVEGLNKHRETPAAADGYLVIPFEMGELASMSAGIVPPGSDESDADLDAALSGAPREAPPPMPGVRTGAPPKLPKRERRSAMTDEDKAFMDRAFSSIADRKAELLAESRQLKRPPPRRELMGTPEGKIQILRDELKTREAQLARLSEIWSVRERELLSVEDRLHEKDVELQGLKMQVDDLLRRFNDAQQSIVQKEREHGATVDDLLLQKFSSEKDLIEVVASKEKDINVLRKEVNLRDEELSRRGADLESWRNEFDKLEKHLGVVTLEFEVKEQKLQDTVRANEADILQLRERGDQFESELSRTVSERDQRYAELDGELQALQERLTQTEQERDATVRGLEARATTAEEHASRSDAEIERLNAERAALEQRLNQQVADLESDIARVTGERDQLRLDKDALEADLTQRVEEREAKISALDRELQETIARNENSEAELNATIQQHRERIGELEGEVEAVKTHLEDRENELNAEIQALQQAKDALEQDLTSQLEDLRAAKDALEADLNGQIQALTEQLDAAQRQGEQLSARVASLEDTVAQRDGTIEGLQTDVSDRDSRIAELTGNLEATSQQLSETQNTLSSTEATLAETRGELEATSQQLSETQGTLSNTEATLSETRGELEATSQQLSETQTRLAQTEETLSTTRGELEATSQTLATTEATLADTQGTLARTEATLSDTQAPSPSTEGTLAETRGELEATSQTLSDTQARLAQTEETLSTTRGELEATSQTLSDTQATLSSTEGTLSETRGELEATSQTLTETQARLAQTEGTLASTQGELEATSQTLATTESTLAQTQDTLARTEATLADTQATLSSTEGTLAETRGELEATSQTLTQTQETLESTRADLAKVTQHRDELDAELHETRDLLQETNGLLARTTEERDARIADLQALNAAKDALEQDLTGQIGQLRADLSETQGLYDAERTAHAALAEETTARINALTGERDNLTAELNATSQQLADTQGQLASTQDALAREEQAHAQSRQAAASMQAELTRQLTEAQANGEDLAEQLIVTKHELGTRVSEVTQLSSTLAQTEDARHHLEDRLQTLTHESQRREELLQNEVDTKGKELSDTLRKLTHVTQEKMRQAEVLNREVTTRTEQVKQLEGQLEHQASEAKKQADALNQQLANVSGELDGARKAIADRDGQLQQAANQQKKLTSERDGLAGQLQQAQAQAQQQAQQAQAAAAEAKKQSDDLAAKLAKADQRIAQLSQEAQKFAADTEAKLKDAQAQLQARTKKAQDLELALENAQSTRARAEKDLNARVAAAETKANEAAARLATAQKERKDLEARQAKELEDLNAKQKAELERREAIKAQEVARLQTSVQEKSKALKVAELELARYKTKAPAAAAPAAKAGAKASEEEHLAATVQANPVIPAAAKPPAKAAGKPAAKKAAAAPTPVPVDEEAPERTMVMQLPTAPEAGEDDWTALVDELDK
>NC_017030.1|WP_014397861.1|6378661_6378889_-|hypothetical-protein
MWAWLKLAMAVLVVVMPGGFPLVLAYIATRTLLERWRVAQAQAREEGRPVSVVRDVVGALHFRDLIREARAATAL
>NC_017030.1|WP_014397862.1|6379079_6380021_+|MoxR-family-ATPase
MSPPQLTSEIRSFTSVEDAARRLEAVGYLSSPEIATAVFLADRMGKPILVEGPAGVGKTELAKALAQALDRTFLRLQCYEGLDEAKALYEWEYAKQLLYTQLLKDKIGELTQGTSTLAEAADRLASGDAVFFSERFLLPRPILQAQLSDTPALLLVDEIDKADPEFEAFLLEVLSDNAVTVPELGTIRAKHVPRVILTSNNARELSDALKRRCLHLHIDFPDRERELRIVRSRLPEVPQVLAEQVVEAVAAIRALDLKKAPSISETLDWAQSLALLNAEALSADIVAATLNLVLKYEGDIEKARANLPTIAQA
>NC_017030.1|WP_014397863.1|6380135_6381086_+|branched-chain-amino-acid-transaminase
MSSTSSTVLRAEHIWLDGKLMKWDEGNVHVMTHALHYGLGVFEGIRAYKTHDGRLAVFRLREHIRRLLDSAHIIMLQIPYSEDELVEATVDLLRKQKQQFANGAYLRPVAFMGDGAMGLGAVNPTRVGITAWDWGAYLGDKGIKEGIRAKVSSFTRNHVNVNMVRGKITGQYVNSILAKREAVLAGYDEAILLDISGFVAEASGENIFLVNKKGVIKTPPLSSPVLDGITRDTVLKLLRDAGHTTIEEVTVTRDALYIANEVFFTGTAAEITPVREVDNRQIGDGKPGPISKYVQDTYFRVVRGQEARYADWLTYV
>NC_017030.1|WP_014397864.1|6381145_6382483_+|AAA-family-ATPase
MPPAGYAYEDNPFKLENPSVLDIAPGEPKSLEDTGLRMGLLADLGLKFLYYAGTGTGVAIAESMCLPWSGVVEHVVDFLAAEKLVDLRGGKGFGRASVEFALTEKGREYARDALTRSTYVGPAPVPIEQYNALISSQTEETPVVGQEDLVAALGHLTVSAELMDKLGPAVNSGRSLFLYGPPGNGKTSLAEAISHMFGGEVFVPHCLEIDNQIIKVFDRIIHTPVPLEMGRDANGRRQTFEMDKRWSLCRRPAVVVGGELTLETLDLIYSESTRFYEAPFQVKANGGMLLIDDFGRQKVHPTDLLNRWIVPLEKRVDFLTLHTGKKFEIPFDQLLVFSTNLDPKELVDEAFLRRIKYKIEVGNPDEESYREIFRRVCEAAGIPYVDQAITYLVEHYYKPRSMEMRSCHPRDLVSLIRDAARYRQIPPALSKDLLDQACEVFLVNL
>NC_017030.1|WP_014397865.1|6382603_6383443_+|Fic-family-protein
MKERYQDIDEKNEQLREYLEIYKGKPPAREYLDRFEMSWIYHDAALEGVVYTHQELMAALFPERTAAEASMIPVVLEIRNHKAVADFIREEAAGAKKQSALTLTTIKRMHDLFLGNTPEALAERARMERRERTEKELAKERDRAGLRKDMPLHRTYFHDITQPAKIQARLEKLVDHTASAEFREFHPIKQAAVVQHEFLQIFPFTEHSGKVGRMCSNLILLRNGYMPAVIHSIDRQRYYESFRAPVATFRTVLMDAMENSLDNGVKYFRDLGRKYKTVE
>NC_017030.1|WP_014397866.1|6383470_6384304_+|deoxyribonuclease-IV
MRIGAHESIAGGVSQAFQRAEAHGARALQIFTKNARGWSAPALTDAETEAFRAEARRTGLPVIAHGSYLVNLAGEAPEAREKSLACVTEELTRCERLGIPLLILHPGSHPDEARGLRLIAEGLDEVHRRCPGYTARVCLEMTAGQGSALGWRFEHLEELLSRVADEARLAVCLDTCHLFAAGYDLRTPKGYAAVMDECDRRVGLHRVRAFHLNDCKKPLGCRVDRHEEPGKGAIGLTAFRCLMKDARFVDTIGVLETPFPERYGENIRLLESLCRRK
>NC_017030.1|WP_014397867.1|6384317_6385439_+|DHH-family-phosphoesterase
MPVTPSLQSRRAQLPAGSELTEPPPARLAKLPAADKLARLLQVAKGHRRALILTHDNPDPDSMAAAVSLAHLLERKAGIEAHVGYGGIIGRAENVAFVRVLRLPVSHVSQIDFSQYDLFGLVDTQPPVRNHSLPARYRADLVVDHHPLREESLLAPFADVGGDFGATSTMLVEYLRAARLEPSVEIATALFYGIKADTRDLGRETTQTDVDSYLWLFPRCDKQLLGQIEHPELPARFFQLFHTSIEKAKVYGTAIITDLEEVYSPDLVAEVAERMMYLEGMKWSLAYGTYRNQLFLSLRVKDRRMNAGRLIRELCDDLGGSSGGHGSMAGARLPLSGSASKRKALKREVVSRFLEAFGVSEERPVSLLSAQDT
>NC_017030.1|WP_014397868.1|6385435_6386581_+|cysteine-desulfurase
MIYWDHNAAAPVRAEVGALLARAFTEGGFGNASSVHGGGREARARLDAARAKVARVLGCEPKEITFTASGSEADALALVGAYAARPVKDRRRVVSTTVEHPSALGALAQLEKDGAQVVRLSPDASGRVPLEAVLEALTPDTALCSLMWANNETGVLQPVAETARACRQRGILFHTDAVQAAGKVPLTLREVDADLLSLSAHKFGGPQGVGVLVVRKGVDVRALTPGHQEGGRRGGTQNVPHAEALALALELAAADQASTAARVAALRDTFEQQVLQRLPGVTVNGAGAPRVPNTSNLRFDGVEGEALLMALDLEDIRVSSGAACASGTLSPSHVLRAMGLSPAEARSSLRFSLGPGTTSAEVTRVVDALCTHVPRVRALGG
>NC_017030.1|WP_014397869.1|6386596_6386770_-|hypothetical-protein
MATERKQQQPEQKQPTRETRHGDERLPPKADEAKEGMPGYGQPDPEVREKNLPDQKW

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Crispr_ID: NC_017030_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_19

6372838-6373070

Orphan

Consensus_repeat	Method
CCACGCCCGTCGTGCGCCGGCCC	CRT

4 spacers

The CRISPR arrays of NC_017030_19

>merge|NC_017030|19|6372838-6373070|CRT
CGACGGCGGTCGTGCGCCGGCCGGTGGAGGTGGAAGAAGACGACTCGAGCACGCCGGCCCCCACGCCCGTCGTGCGCCGGCCCGCCTCCGAGGATGAGGCCCCCGCCCCCACGCCCGTCGTGCGCCGGCCCCTGCCCGAAGACGAACCTCCCGCGGCCACGCCCATCGTGCGCCGTCCCACCTCCCTCTCGGAGGACGAGGAGCGCGCGCCCACGCCCGTCGTTCGCCGGACC

>NC_017030|19|4|6372838-6373070|CRT
CGACGGCGGTCGTGCGCCGGCCG	GTGGAGGTGGAAGAAGACGACTCGAGCACGCCGGCCC
CCACGCCCGTCGTGCGCCGGCCC	GCCTCCGAGGATGAGGCCCCCGCCC
CCACGCCCGTCGTGCGCCGGCCC	CTGCCCGAAGACGAACCTCCCGCGG
CCACGCCCATCGTGCGCCGTCCC	ACCTCCCTCTCGGAGGACGAGGAGCGCGCGC
CCACGCCCGTCGTTCGCCGGACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_043321831.1\|6362466_6364392_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_017030.1\|WP_014397867.1\|6384317_6385439_+\|DHH-family-phosphoesterase	unknown	unknown	gnl\|CDD\|223691
NC_017030.1\|WP_014397861.1\|6378661_6378889_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397860.1\|6373949_6378545_+\|response-regulator	unknown	unknown	gnl\|CDD\|274008
NC_017030.1\|WP_014397849.1\|6355403_6357998_-\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|235840
NC_017030.1\|WP_014397855.1\|6364452_6365046_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238870
NC_017030.1\|WP_014397864.1\|6381145_6382483_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223679
NC_017030.1\|WP_014397866.1\|6383470_6384304_+\|deoxyribonuclease-IV	unknown	unknown	gnl\|CDD\|179214
NC_017030.1\|WP_043321829.1\|6360533_6361409_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|188247
NC_017030.1\|WP_014397869.1\|6386596_6386770_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397853.1\|6361491_6362250_-\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|376831
NC_017030.1\|WP_014397865.1\|6382603_6383443_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|376885
NC_017030.1\|WP_043321833.1\|6366711_6368301_-\|DUF1957-domain-containing-protein	unknown	unknown	gnl\|CDD\|212104
NC_017030.1\|WP_014397851.1\|6359293_6360508_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_017030.1\|WP_014397868.1\|6385435_6386581_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_017030.1\|WP_014397850.1\|6358021_6359152_-\|DNA-processing-protein-DprA	unknown	unknown	gnl\|CDD\|376794
NC_017030.1\|WP_014397863.1\|6380135_6381086_+\|branched-chain-amino-acid-transaminase	unknown	unknown	gnl\|CDD\|235841
NC_017030.1\|WP_014397862.1\|6379079_6380021_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_017030.1\|WP_014397856.1\|6365110_6366610_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NC_017030.1\|WP_014397858.1\|6368327_6370934_-\|DUF4912-domain-containing-protein	unknown	unknown	gnl\|CDD\|379808

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_043321831.1\|6362466_6364392_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.48377e-60
NC_017030.1\|WP_014397867.1\|6384317_6385439_+\|DHH-family-phosphoesterase	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	1.14259e-46
NC_017030.1\|WP_014397860.1\|6373949_6378545_+\|response-regulator	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.11534e-25
NC_017030.1\|WP_014397849.1\|6355403_6357998_-\|type-I-DNA-topoisomerase	gnl\|CDD\|235840	PRK06599, PRK06599, DNA topoisomerase I; Validated.	0
NC_017030.1\|WP_014397855.1\|6364452_6365046_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238870	cd01832, SGNH_hydrolase_like_1, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.	1.44405e-44
NC_017030.1\|WP_014397864.1\|6381145_6382483_+\|AAA-family-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	6.40552e-10
NC_017030.1\|WP_014397866.1\|6383470_6384304_+\|deoxyribonuclease-IV	gnl\|CDD\|179214	PRK01060, PRK01060, endonuclease IV; Provisional.	1.1891e-105
NC_017030.1\|WP_043321829.1\|6360533_6361409_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|188247	TIGR02795, Uncharacterized_protein_in_oprL_3'region, tol-pal system protein YbgF. Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.	1.39824e-20
NC_017030.1\|WP_014397853.1\|6361491_6362250_-\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|376831	pfam02578, Cu-oxidase_4, Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.	3.47115e-86
NC_017030.1\|WP_014397865.1\|6382603_6383443_+\|Fic-family-protein	gnl\|CDD\|376885	pfam02661, Fic, Fic/DOC family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.	1.22408e-09
NC_017030.1\|WP_043321833.1\|6366711_6368301_-\|DUF1957-domain-containing-protein	gnl\|CDD\|212104	cd10792, GH57N_AmyC_like, N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins. Alpha-amylases (alpha-1,4-glucan-4-glucanohydrolases, EC 3.2.1.1) play essential roles in alpha-glucan metabolism by catalyzing the hydrolysis of polysaccharides such as amylose starch, and beta-limit dextrin. This subfamily is represented by a novel alpha-amylase (AmyC) encoded by hyperthermophilic organism Thermotoga maritime ORF tm1438, and its prokaryotic homologs. AmyC functions as a homotetramer and shows thermostable amylolytic activity. It is strongly inhibited by acarbose. AmyC is composed of a N-terminal catalytic domain, containing a distorted TIM-barrel structure with a characteristic (beta/alpha)7 fold motif, and two additional less conserved domains. There are other two canonical alpha-amylases encoded from T. maritime that lack the sequence similarity to AmyC, and belong to a different superfamily.	0
NC_017030.1\|WP_014397851.1\|6359293_6360508_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	2.31985e-07
NC_017030.1\|WP_014397868.1\|6385435_6386581_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	2.12326e-162
NC_017030.1\|WP_014397850.1\|6358021_6359152_-\|DNA-processing-protein-DprA	gnl\|CDD\|376794	pfam02481, DNA_processg_A, DNA recombination-mediator protein A. The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyze the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation.	2.82801e-73
NC_017030.1\|WP_014397863.1\|6380135_6381086_+\|branched-chain-amino-acid-transaminase	gnl\|CDD\|235841	PRK06606, PRK06606, branched-chain amino acid transaminase.	3.95407e-176
NC_017030.1\|WP_014397862.1\|6379079_6380021_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.7715e-41
NC_017030.1\|WP_014397856.1\|6365110_6366610_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.08869e-152
NC_017030.1\|WP_014397858.1\|6368327_6370934_-\|DUF4912-domain-containing-protein	gnl\|CDD\|379808	pfam16258, DUF4912, Domain of unknown function (DUF4912). This family consists of uncharacterized proteins around 160 residues in length and is mainly found in various Clostridium species. The function of this family is unknown.	1.72535e-29

>NC_017030.1|WP_014397858.1|6368327_6370934_-|DUF4912-domain-containing-protein
MDERKGVTVSYLRQLARKYLREGAGASRGRELVSSLAERIPALGRLARMAGLATSRRGSGDVGGEEKALDSGPADSRDAKGPASESVPLPPPESAAAPQARELSEEPITQPGSGPRTRPARVVTFPARVKARRDPDEEDTQPLSPEAPTPRPSSSPKGDSPAAAKPAPASEPPHAAEPLVEGFFVTKMAGEKEARRHHLLEEQAPRLPPADASPERDEHLAMLPLDYQDDAMVLLARDPHTLFVFWDFSDASRNRALDELPAPRAVLKVFDGEGVSREVDFALESRSFYLQGMTPGRTYRVEAHFVGSDGRSRRIGHSSNRATLPPAGPSADTSIRFLRMPPPPVVDRLREAVPSAASARVPRVEEREYVTWRRVQLPGSAGVVDVPEVHRERTEAYVDAPRVPGASDQRYVEEAYLESAPRAPGASDQQYARVGEATLGEGAVLAPSRAPGASDQRYLAVELAPGASDQRYDVASPYLEVPRAPGASDQRYDVASPYLEVPRAPAASDQRYGQAQLPGGVSEYRYLEVPRAPGASDQRYVAGGQGTSDQRYLSVPRAAEASDQRYLSVPRAAGASDQRYLTVPRAAGASDQQYLSVPRAAGASDQRYLSADRATGASDQQYLTVPRAAGASDQRYLSVDRATGASDQQYLTVPRAAGASDQRCLSADHATGTSDQPGASRTAGGSDAWSPESPRSRGDVTEARDLPSSPPVGTSAPVGAEASFPSGPSTQGTASTDSWRPTEPEPPKDPWALSVARGPSASEQRALDKAREAARRAALASVPVSPSPAKVEAPAAMPASTPPAKAEAPTAPTPKVESRAAPSAVAPKADAVKSPPAAPSKAAQNPPEPKPSGSKSSTRSRPSRRGRK
>NC_017030.1|WP_043321833.1|6366711_6368301_-|DUF1957-domain-containing-protein
MSLGSLALVLHAHLPFVRHPEYEDFLEEDWLYEAISETYLPLLRVFDRLVEDRVPFRVTMTLSPTLVSMLNDELLRERYARRLDSLCELGAREVHRTRDDPTFHPLAVFHRDHFESLRLAYHNHYRRDLVAAFRRLQDSGHLDILTCNATHGFLPLMQQTPEAVRAQVTVAANHYRQNFGRDPAGIWLAECGYYPGLERILSAERIRYFFADTHALTDATPRPLHGPYAPIFTEPGVAAFARDPESSQQVWSTEHGYPGDPVYREFYRDIGWDLDLDYIRPFIQPTGDRKNTGFKYFRITGKTNDKQPYDPAAARERAWVHAGNFLFNRERQFEYLASRMGGRKPVVVAPYDAELFGHWWFEGPHFIDALIRQAARNPSRFTLISPLDDLREHPENQVATPPMSSWGAGGYANMWLDGTNDWIYRHLNHAARQMVELARDFPDAPSLKRRALNQAARELLLAQASDWAFIMKTGTMVDYAVRRTKEHLQRFLRLHDQVRAGTVDESWLSHVEGRNNLFPELDYRVYRPG
>NC_017030.1|WP_014397856.1|6365110_6366610_-|trypsin-like-peptidase-domain-containing-protein
MTHTLPPFRRKLVAAVLVLASPTLALAQAPAPQPPAPKTQQAASGQAGNLQPATREAQSLASLAPLVESVKSAVVNVDVQARPEMPEGMEDNPLFDRFFGGNGRGRGGRSEREQIRQGAGSGFIIDPKGLVLTNNHVIEDAVTITIRLDDGRSFTGEVVGRDPLTDVAVVKIKEKVDQLPSVKLGDSDAVRVGDWVLAIGNPFGLASSVSVGILSARAREIGASVYDDFLQTDAAINPGNSGGPLFNMKGEVVGINTAIVGGGTGIGFSVPSNLIKALLPQLEKEGAVTRGWLGVGIQPLTRELGQALKLSVSEGAILTQITPDSPAAKAGLKPDDVVVAVDGKQVRSDSELTRTVALKKPNSVATLTLYRDGKKQDVKVTMGTRPDLEGLSKKKPGATDEQDSSRRVGVSLQDLDARTASQAGFTERAGALITDIVPGSPADRAQLTPGMLVVEANKKPIASAKELAAAIRAAPKGSTLLLRVAGPGGGRLLRALTVP
>NC_017030.1|WP_014397855.1|6364452_6365046_-|SGNH/GDSL-hydrolase-family-protein
MSVNYVSLGDSTAVGVGASQGGGYPDRLASRLRKGGLPVGHTNLGQSGARVRDIVNNALKRVIALQPTLITLGVGTNDIWRGTEVAEFQDDLDRIARRLKQTGASMVVVNLADMALAPVAKMVPSALYEGRIEQFNDAIASVARSHGLHLVDLYTASREMIPRRPDFFCSDGFHPSAEGYEEWADLMLPVVRTLVRR
>NC_017030.1|WP_043321831.1|6362466_6364392_+|diguanylate-cyclase
MALGSETIGRKLLWSIALPGLVVALLGVGHFSREARQAVREGTHLEALALAEAVASTFTLPQAPGAAPHGAVAEVLASDTRLFRSVEDLRVLTPEGRIRWSRRPAEQGHPHPEASRLSATGPETARSSDHGTEVVRPLGGPECSGCHTGEAAQRMGVLQVRMGEPALTRQLQTVFQDALGAMVLFVGILGLVTWLSLRFVLTAPLKRLSEAMGRAADGDLLVRAEARGTDEISRLGAAFNQMLARLTSMKVEEIDTHRDLQLVKEKLALKDELEERLTELSLLFDVARSLNTTLELDELLSRITRMVVERLHIPDFSIMLLNEEGLLEVKHAWPQGRGLEGHTFAMGEGACGRAAQARKAVYLPDLTDSTSVFARRGLRGGSEQGSLLAVPMVHADTLLGVINFQRPETASISAEEIELFTAVADQAATAVTNARLHAETVKLTLTDALTGVPNRRHLFQRMDLELARAQRFGVPMALLMVDVDHFKRLNDLAGHRAGDETLRRVSDVLRNRARKVDTLGRYGGEEFVLLLPQVSKATAVEVAETLRRAVADSVTLSRPGLPGGHVTVSIGVAHFPTDATSQDMLVDCADSALYCSKRTGRNRVTAFEPGMEVHPGRERSISTPPADAPSTPPAPSGIAKA
>NC_017030.1|WP_014397853.1|6361491_6362250_-|peptidoglycan-editing-factor-PgeF
MTPPVFLTSELLPVPHGFATRAGGVSEGPYASLNLGFSVNDERSRVEENHRLLARAAGARLGALCRVSQVHGDRVLEARGESDDVLRPTLGEADALWTEGEGSWVAVGTADCVPVLIVDPRGKRVAAVHSGWKGTDLEISARTVETLVARGSRPEDLLAAVGPCIQACCYEVSPELGDRFRARFGPDVVRAGDKPHLDLPRAVKASLLKAGLTPEHVDVLQACTACDPDRFFSHRRDAGRTGRHLNYVLHRF
>NC_017030.1|WP_043321829.1|6360533_6361409_-|tetratricopeptide-repeat-protein
MPVRPFLFRLFAAVALSAPTACATTAASQSEVGRLEAEVRTLRASQASLLERLERLENRDAVSRARAATPAPAAASPKATASTKPEAASPEGGEALSLAPAELTVVRLKPKKEPAPRINTAVAVVEPDSDQMEMFISPVEGSNGTGSVGSISASTAARMEPPEKDPDILDAEYERAVAMLRTGNVEGGVETLTRFAAENPRHPRADNALYFSGLGQMGLKDAAGAAKTFEKLIKNYPAGDAVQDGMLRLAECRVRLNQAVDARALYTRVVTQFPGTAAATQAEQRLAALSP
>NC_017030.1|WP_014397851.1|6359293_6360508_-|LysM-peptidoglycan-binding-domain-containing-protein
MRSRILASLLVPLTVAPAWTAFAQDAQEEEPQPASETEGQDISDDVEQRPTSVTLPPGAAQGRESAPGQVHTVETGDTLWDLSQRYLGSPWYWPKVWSYNPQIANPHWIYPGNNVKFFPGGEEVPARVEGGDLPSDDVAAPTDVSGGSLVSVVGKIGYDPSKSSPVTTKGFVTTRELDEAGRIEGSTSEALMLSAPEKVYLRFKKRGAAKIGDRYVIFHTVEEVKHPVTNARTGYLTELLGTVQVVSINNDVVTARIMETWDPISRGDLVGPSSEKLSERISPKPNSKEIPGFVLTPMTPGQTLLGEHNFVVVDRGTADGVQVGNTFTIERRGDPSLDVLGRSDYKMGDAGKGQKTYPWEAVAQCMVTEVRERTSNCLMTRSMVEVSAGDRATMRKDGTPTASR
>NC_017030.1|WP_014397850.1|6358021_6359152_-|DNA-processing-protein-DprA
MADTNTDTHLHWDEQRATLALWAIAGLGPRTLDAVRAFAGGALSRLAAVPVRDWVADVPVPATVRQRLAAVASLDALASRTEEACAQSGLQVAFAGSPPYPSRLVGLEDAPPLLFYLGHPGPPRRRLAMVGSRHPDQGFLPFARTFARKVAEAGVGVVSGAAEGVDRACHWGALDVGAETWAFLGSALDALDPAQARLLPHFLERGGVYFSELPPGVRASTTTFPRRNRLISGASDAVLVMRAGEGSGALYTAEAAQAQGRPVFALPGDVWQPAAAGCNALLADGRARACTSAESICAVVGVHPVRAVPAGRDAGWWEALSAEARGAYGLLDRAPRSFDEVLAASPLSPAALTSALVELELSGLVVQHPGKRYEKV
>NC_017030.1|WP_014397849.1|6355403_6357998_-|type-I-DNA-topoisomerase
MATRKKTQAAQTEAAAEETPKKAAAKKPAAKKAAKKKTAAKKVTAKKKTAARRRGADADELPTVDADADAEEEVPERRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKIGVDVEDDFKPEYTVIKGKEKVLNELKKMAKTVDRVFLATDPDREGEAIAWHIKEELGHPDSLRVTFNEITKRAVQDAIAQPRELNQDNYDSQQTRRILDRLVGYQISPLLWKKIRRGLSAGRVQSVAVRLIVEREAEIKAFQPEEYWTLDALVQGPQGPPPFKAKLSRVDGKKVELKDRATTDGLVAELKDAPFTVTKVDRKERRRNAPAPFITSKLQQEAANRLHFTAKKTMTLAQKLYEGVPLGEEGQTALITYMRTDSTRLSDDAVTQVREFIGQKYGADYLPAEPMVYKSRKSAQDAHEAIRPTSLEYPPERVRPFFDAMDELDMFRLYELIWNRFVACQMKPAVYDQTAADITAGRATFRASGSTLKFPGYLGVYGAGLTPEEEAAAEKAKAAGEEGAEDVVGELPPLNEGEVLTLDKLLNEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSNIQDKKYVEKLESRFRPTDLGQMTNELLVKHFPHELDVSFTASMEEKLDQISDGGASWKTVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIACEKCGNPFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVIVEEETTDEKCEKCGKPMVIKRGRFGRFMACSGYPDCKTSKPISIGVNCPECKVGYLTERRSGRGKIFFGCNRYPECKFAAWDRPLAEQCPQCASPYLLQKFSKRDGAYIACPNKECDYRREVVEPAIPGASAEGAPAPTPTVEA
>NC_017030.1|WP_014397860.1|6373949_6378545_+|response-regulator
MERRVLIVESQNDFALSMASVLKSAGYNTAMATTASDAQRELEKRRPDLVVVRAELPDQSGFALCGQIKKGKWGQNLKVLLLSSDSGVEGLNKHRETPAAADGYLVIPFEMGELASMSAGIVPPGSDESDADLDAALSGAPREAPPPMPGVRTGAPPKLPKRERRSAMTDEDKAFMDRAFSSIADRKAELLAESRQLKRPPPRRELMGTPEGKIQILRDELKTREAQLARLSEIWSVRERELLSVEDRLHEKDVELQGLKMQVDDLLRRFNDAQQSIVQKEREHGATVDDLLLQKFSSEKDLIEVVASKEKDINVLRKEVNLRDEELSRRGADLESWRNEFDKLEKHLGVVTLEFEVKEQKLQDTVRANEADILQLRERGDQFESELSRTVSERDQRYAELDGELQALQERLTQTEQERDATVRGLEARATTAEEHASRSDAEIERLNAERAALEQRLNQQVADLESDIARVTGERDQLRLDKDALEADLTQRVEEREAKISALDRELQETIARNENSEAELNATIQQHRERIGELEGEVEAVKTHLEDRENELNAEIQALQQAKDALEQDLTSQLEDLRAAKDALEADLNGQIQALTEQLDAAQRQGEQLSARVASLEDTVAQRDGTIEGLQTDVSDRDSRIAELTGNLEATSQQLSETQNTLSSTEATLAETRGELEATSQQLSETQGTLSNTEATLSETRGELEATSQQLSETQTRLAQTEETLSTTRGELEATSQTLATTEATLADTQGTLARTEATLSDTQAPSPSTEGTLAETRGELEATSQTLSDTQARLAQTEETLSTTRGELEATSQTLSDTQATLSSTEGTLSETRGELEATSQTLTETQARLAQTEGTLASTQGELEATSQTLATTESTLAQTQDTLARTEATLADTQATLSSTEGTLAETRGELEATSQTLTQTQETLESTRADLAKVTQHRDELDAELHETRDLLQETNGLLARTTEERDARIADLQALNAAKDALEQDLTGQIGQLRADLSETQGLYDAERTAHAALAEETTARINALTGERDNLTAELNATSQQLADTQGQLASTQDALAREEQAHAQSRQAAASMQAELTRQLTEAQANGEDLAEQLIVTKHELGTRVSEVTQLSSTLAQTEDARHHLEDRLQTLTHESQRREELLQNEVDTKGKELSDTLRKLTHVTQEKMRQAEVLNREVTTRTEQVKQLEGQLEHQASEAKKQADALNQQLANVSGELDGARKAIADRDGQLQQAANQQKKLTSERDGLAGQLQQAQAQAQQQAQQAQAAAAEAKKQSDDLAAKLAKADQRIAQLSQEAQKFAADTEAKLKDAQAQLQARTKKAQDLELALENAQSTRARAEKDLNARVAAAETKANEAAARLATAQKERKDLEARQAKELEDLNAKQKAELERREAIKAQEVARLQTSVQEKSKALKVAELELARYKTKAPAAAAPAAKAGAKASEEEHLAATVQANPVIPAAAKPPAKAAGKPAAKKAAAAPTPVPVDEEAPERTMVMQLPTAPEAGEDDWTALVDELDK
>NC_017030.1|WP_014397861.1|6378661_6378889_-|hypothetical-protein
MWAWLKLAMAVLVVVMPGGFPLVLAYIATRTLLERWRVAQAQAREEGRPVSVVRDVVGALHFRDLIREARAATAL
>NC_017030.1|WP_014397862.1|6379079_6380021_+|MoxR-family-ATPase
MSPPQLTSEIRSFTSVEDAARRLEAVGYLSSPEIATAVFLADRMGKPILVEGPAGVGKTELAKALAQALDRTFLRLQCYEGLDEAKALYEWEYAKQLLYTQLLKDKIGELTQGTSTLAEAADRLASGDAVFFSERFLLPRPILQAQLSDTPALLLVDEIDKADPEFEAFLLEVLSDNAVTVPELGTIRAKHVPRVILTSNNARELSDALKRRCLHLHIDFPDRERELRIVRSRLPEVPQVLAEQVVEAVAAIRALDLKKAPSISETLDWAQSLALLNAEALSADIVAATLNLVLKYEGDIEKARANLPTIAQA
>NC_017030.1|WP_014397863.1|6380135_6381086_+|branched-chain-amino-acid-transaminase
MSSTSSTVLRAEHIWLDGKLMKWDEGNVHVMTHALHYGLGVFEGIRAYKTHDGRLAVFRLREHIRRLLDSAHIIMLQIPYSEDELVEATVDLLRKQKQQFANGAYLRPVAFMGDGAMGLGAVNPTRVGITAWDWGAYLGDKGIKEGIRAKVSSFTRNHVNVNMVRGKITGQYVNSILAKREAVLAGYDEAILLDISGFVAEASGENIFLVNKKGVIKTPPLSSPVLDGITRDTVLKLLRDAGHTTIEEVTVTRDALYIANEVFFTGTAAEITPVREVDNRQIGDGKPGPISKYVQDTYFRVVRGQEARYADWLTYV
>NC_017030.1|WP_014397864.1|6381145_6382483_+|AAA-family-ATPase
MPPAGYAYEDNPFKLENPSVLDIAPGEPKSLEDTGLRMGLLADLGLKFLYYAGTGTGVAIAESMCLPWSGVVEHVVDFLAAEKLVDLRGGKGFGRASVEFALTEKGREYARDALTRSTYVGPAPVPIEQYNALISSQTEETPVVGQEDLVAALGHLTVSAELMDKLGPAVNSGRSLFLYGPPGNGKTSLAEAISHMFGGEVFVPHCLEIDNQIIKVFDRIIHTPVPLEMGRDANGRRQTFEMDKRWSLCRRPAVVVGGELTLETLDLIYSESTRFYEAPFQVKANGGMLLIDDFGRQKVHPTDLLNRWIVPLEKRVDFLTLHTGKKFEIPFDQLLVFSTNLDPKELVDEAFLRRIKYKIEVGNPDEESYREIFRRVCEAAGIPYVDQAITYLVEHYYKPRSMEMRSCHPRDLVSLIRDAARYRQIPPALSKDLLDQACEVFLVNL
>NC_017030.1|WP_014397865.1|6382603_6383443_+|Fic-family-protein
MKERYQDIDEKNEQLREYLEIYKGKPPAREYLDRFEMSWIYHDAALEGVVYTHQELMAALFPERTAAEASMIPVVLEIRNHKAVADFIREEAAGAKKQSALTLTTIKRMHDLFLGNTPEALAERARMERRERTEKELAKERDRAGLRKDMPLHRTYFHDITQPAKIQARLEKLVDHTASAEFREFHPIKQAAVVQHEFLQIFPFTEHSGKVGRMCSNLILLRNGYMPAVIHSIDRQRYYESFRAPVATFRTVLMDAMENSLDNGVKYFRDLGRKYKTVE
>NC_017030.1|WP_014397866.1|6383470_6384304_+|deoxyribonuclease-IV
MRIGAHESIAGGVSQAFQRAEAHGARALQIFTKNARGWSAPALTDAETEAFRAEARRTGLPVIAHGSYLVNLAGEAPEAREKSLACVTEELTRCERLGIPLLILHPGSHPDEARGLRLIAEGLDEVHRRCPGYTARVCLEMTAGQGSALGWRFEHLEELLSRVADEARLAVCLDTCHLFAAGYDLRTPKGYAAVMDECDRRVGLHRVRAFHLNDCKKPLGCRVDRHEEPGKGAIGLTAFRCLMKDARFVDTIGVLETPFPERYGENIRLLESLCRRK
>NC_017030.1|WP_014397867.1|6384317_6385439_+|DHH-family-phosphoesterase
MPVTPSLQSRRAQLPAGSELTEPPPARLAKLPAADKLARLLQVAKGHRRALILTHDNPDPDSMAAAVSLAHLLERKAGIEAHVGYGGIIGRAENVAFVRVLRLPVSHVSQIDFSQYDLFGLVDTQPPVRNHSLPARYRADLVVDHHPLREESLLAPFADVGGDFGATSTMLVEYLRAARLEPSVEIATALFYGIKADTRDLGRETTQTDVDSYLWLFPRCDKQLLGQIEHPELPARFFQLFHTSIEKAKVYGTAIITDLEEVYSPDLVAEVAERMMYLEGMKWSLAYGTYRNQLFLSLRVKDRRMNAGRLIRELCDDLGGSSGGHGSMAGARLPLSGSASKRKALKREVVSRFLEAFGVSEERPVSLLSAQDT
>NC_017030.1|WP_014397868.1|6385435_6386581_+|cysteine-desulfurase
MIYWDHNAAAPVRAEVGALLARAFTEGGFGNASSVHGGGREARARLDAARAKVARVLGCEPKEITFTASGSEADALALVGAYAARPVKDRRRVVSTTVEHPSALGALAQLEKDGAQVVRLSPDASGRVPLEAVLEALTPDTALCSLMWANNETGVLQPVAETARACRQRGILFHTDAVQAAGKVPLTLREVDADLLSLSAHKFGGPQGVGVLVVRKGVDVRALTPGHQEGGRRGGTQNVPHAEALALALELAAADQASTAARVAALRDTFEQQVLQRLPGVTVNGAGAPRVPNTSNLRFDGVEGEALLMALDLEDIRVSSGAACASGTLSPSHVLRAMGLSPAEARSSLRFSLGPGTTSAEVTRVVDALCTHVPRVRALGG
>NC_017030.1|WP_014397869.1|6386596_6386770_-|hypothetical-protein
MATERKQQQPEQKQPTRETRHGDERLPPKADEAKEGMPGYGQPDPEVREKNLPDQKW

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Crispr_ID: NC_017030_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_21

6376293-6376717

Orphan

Consensus_repeat	Method
GAGCTGGAGGCCACNCAGCCAGACNCT	CRT

5 spacers

The CRISPR arrays of NC_017030_21

>merge|NC_017030|21|6376293-6376717|CRT
GAGCTGGAGGCCACCAGCCAGACCCTCTCCGACACGCAGGCCAGGCTCGCGCAGACGGAGGAGACGCTCTCCACCACGCGCGGTGAGCTGGAAGCCACCAGCCAGACCCTCTCCGACACGCAGGCCACGCTCTCCAGCACGGAGGGCACGCTCTCGGAGACCCGCGGCGAGCTGGAGGCCACCAGCCAGACGCTGACGGAGACGCAGGCCAGGCTCGCGCAGACGGAAGGGACGCTCGCGTCCACCCAGGGCGAGCTGGAGGCCACCAGCCAGACGCTGGCCACCACCGAGTCCACGCTCGCGCAGACGCAGGACACGCTGGCGCGCACGGAGGCCACGCTCGCCGACACGCAGGCGACCCTCTCCAGCACGGAAGGCACGCTCGCGGAGACGCGCGGTGAGCTGGAGGCCACCAGCCAGACGCT

>NC_017030|21|5|6376293-6376717|CRT
GAGCTGGAGGCCACCAGCCAGACCCT	CTCCGACACGCAGGCCAGGCTCGCGCAGACGGAGGAGACGCTCTCCACCACGCGCGGT
GAGCTGGAAGCCACCAGCCAGACCCT	CTCCGACACGCAGGCCACGCTCTCCAGCACGGAGGGCACGCTCTCGGAGACCCGCGGC
GAGCTGGAGGCCACCAGCCAGACGCT	GACGGAGACGCAGGCCAGGCTCGCGCAGACGGAAGGGACGCTCGCGTCCACCCAGGGC
GAGCTGGAGGCCACCAGCCAGACGCT	GGCCACCACCGAGTCCACGCTCGCGCAGACGCAGGACACGCTGGCG
CGCACGGAGGCCACGCTCGCCGACAC	GCAGGCGACCCTCTCCAGCACGGAAGGCACGCTCGCGGAGACGCGCGGT
GAGCTGGAGGCCACCAGCCAGACGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014397870.1\|6386878_6387874_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_043321831.1\|6362466_6364392_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_017030.1\|WP_014397867.1\|6384317_6385439_+\|DHH-family-phosphoesterase	unknown	unknown	gnl\|CDD\|223691
NC_017030.1\|WP_014397861.1\|6378661_6378889_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397855.1\|6364452_6365046_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238870
NC_017030.1\|WP_014397864.1\|6381145_6382483_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223679
NC_017030.1\|WP_014397866.1\|6383470_6384304_+\|deoxyribonuclease-IV	unknown	unknown	gnl\|CDD\|179214
NC_017030.1\|WP_043321829.1\|6360533_6361409_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|188247
NC_017030.1\|WP_014397869.1\|6386596_6386770_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397853.1\|6361491_6362250_-\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|376831
NC_017030.1\|WP_014397865.1\|6382603_6383443_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|376885
NC_017030.1\|WP_043321833.1\|6366711_6368301_-\|DUF1957-domain-containing-protein	unknown	unknown	gnl\|CDD\|212104
NC_017030.1\|WP_014397851.1\|6359293_6360508_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NC_017030.1\|WP_014397868.1\|6385435_6386581_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_017030.1\|WP_014397850.1\|6358021_6359152_-\|DNA-processing-protein-DprA	unknown	unknown	gnl\|CDD\|376794
NC_017030.1\|WP_014397863.1\|6380135_6381086_+\|branched-chain-amino-acid-transaminase	unknown	unknown	gnl\|CDD\|235841
NC_017030.1\|WP_148282604.1\|6371111_6373850_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340825
NC_017030.1\|WP_014397862.1\|6379079_6380021_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_017030.1\|WP_014397856.1\|6365110_6366610_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NC_017030.1\|WP_014397858.1\|6368327_6370934_-\|DUF4912-domain-containing-protein	unknown	unknown	gnl\|CDD\|379808

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014397870.1\|6386878_6387874_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.09455e-91
NC_017030.1\|WP_043321831.1\|6362466_6364392_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	4.48377e-60
NC_017030.1\|WP_014397867.1\|6384317_6385439_+\|DHH-family-phosphoesterase	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	1.14259e-46
NC_017030.1\|WP_014397855.1\|6364452_6365046_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238870	cd01832, SGNH_hydrolase_like_1, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.	1.44405e-44
NC_017030.1\|WP_014397864.1\|6381145_6382483_+\|AAA-family-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	6.40552e-10
NC_017030.1\|WP_014397866.1\|6383470_6384304_+\|deoxyribonuclease-IV	gnl\|CDD\|179214	PRK01060, PRK01060, endonuclease IV; Provisional.	1.1891e-105
NC_017030.1\|WP_043321829.1\|6360533_6361409_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|188247	TIGR02795, Uncharacterized_protein_in_oprL_3'region, tol-pal system protein YbgF. Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.	1.39824e-20
NC_017030.1\|WP_014397853.1\|6361491_6362250_-\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|376831	pfam02578, Cu-oxidase_4, Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.	3.47115e-86
NC_017030.1\|WP_014397865.1\|6382603_6383443_+\|Fic-family-protein	gnl\|CDD\|376885	pfam02661, Fic, Fic/DOC family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.	1.22408e-09
NC_017030.1\|WP_043321833.1\|6366711_6368301_-\|DUF1957-domain-containing-protein	gnl\|CDD\|212104	cd10792, GH57N_AmyC_like, N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins. Alpha-amylases (alpha-1,4-glucan-4-glucanohydrolases, EC 3.2.1.1) play essential roles in alpha-glucan metabolism by catalyzing the hydrolysis of polysaccharides such as amylose starch, and beta-limit dextrin. This subfamily is represented by a novel alpha-amylase (AmyC) encoded by hyperthermophilic organism Thermotoga maritime ORF tm1438, and its prokaryotic homologs. AmyC functions as a homotetramer and shows thermostable amylolytic activity. It is strongly inhibited by acarbose. AmyC is composed of a N-terminal catalytic domain, containing a distorted TIM-barrel structure with a characteristic (beta/alpha)7 fold motif, and two additional less conserved domains. There are other two canonical alpha-amylases encoded from T. maritime that lack the sequence similarity to AmyC, and belong to a different superfamily.	0
NC_017030.1\|WP_014397851.1\|6359293_6360508_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	2.31985e-07
NC_017030.1\|WP_014397868.1\|6385435_6386581_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	2.12326e-162
NC_017030.1\|WP_014397850.1\|6358021_6359152_-\|DNA-processing-protein-DprA	gnl\|CDD\|376794	pfam02481, DNA_processg_A, DNA recombination-mediator protein A. The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyze the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation.	2.82801e-73
NC_017030.1\|WP_014397863.1\|6380135_6381086_+\|branched-chain-amino-acid-transaminase	gnl\|CDD\|235841	PRK06606, PRK06606, branched-chain amino acid transaminase.	3.95407e-176
NC_017030.1\|WP_148282604.1\|6371111_6373850_+\|glycosyltransferase	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	1.17905e-43
NC_017030.1\|WP_014397862.1\|6379079_6380021_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.7715e-41
NC_017030.1\|WP_014397856.1\|6365110_6366610_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.08869e-152
NC_017030.1\|WP_014397858.1\|6368327_6370934_-\|DUF4912-domain-containing-protein	gnl\|CDD\|379808	pfam16258, DUF4912, Domain of unknown function (DUF4912). This family consists of uncharacterized proteins around 160 residues in length and is mainly found in various Clostridium species. The function of this family is unknown.	1.72535e-29

>NC_017030.1|WP_148282604.1|6371111_6373850_+|glycosyltransferase
MPGPSGSSRRLTEYLKALPDRFSVVVLSAKTPDHSHIEKYQGARLLRVPVGSGDLASRIQSFERAVRRQLESEDYALAHFTDPFGGYALCELKADYGYRLIYEAQTFPSQELRYTHPQTDGDRRFLSKIRRQELFCLMNADLVVTGSQTTRAFIQGLGAAEDQLRTIRAPVDLKPYDPEVLGAPDGSPLRMMYLGSHVGWQGLPTLLRATALAAQQVDVRLTLVGAHHPDWKPHLEDLVNDLGIKEKVDFQPPVAHDDLVKVLALADVGVLPLDDSERNRLQGGPLAKVSEYLAAGRPVIAADLPVTRELIPKDAAIFFPPGDSRALSERILDLARDVPRRVALGKAGRAFAEKVLDAGLIRGQLLDLYDSLLEKRGHGPVEAASEPPDVTMTGTPTNRLASLGMPEASQPAPAPKPPAKPAVQAASDEADPPPTKEGPEDAPVVMGMALDDGMDTRLVKTEPDMRPDEVPMVMGLPLRESATAAPAPAGREATPPPEPEAAPQTTDDTAKTTLPSSPAKDGEPEPLGGRGSEPAPPTEMVTSPLVKALGLKELSRDDAGDSDAEARASEDGSSGATAVVRRPVEVEEDDSSTPAPTPVVRRPASEDEAPAPTPVVRRPLPEDEPPAATPIVRRPTSLSEDEERAPTPVVRRTGVMREEEEAPAPTPIVPMRSLLTGARSTSASRAQRPQDSTPSEPPRLFPTPSPMADAEKPPIRGGLAADPGRPASRPPVLAESDKPPIRGGSVSDADRPPQLPPRAAAPPPVPRQGPPRLSPTPPVLKPSVSSDDEPEEIAADEAQSLDDDAGNTPSNASAALDEAEEIAADEVHDADALEVEAADAEEAVDEGPPPAPPDSTLNPWFAQLAHGYCPPEGARFARHTPPTNFPGRDPEEGVPPGSVPPVGQGAVRGKNS
>NC_017030.1|WP_014397858.1|6368327_6370934_-|DUF4912-domain-containing-protein
MDERKGVTVSYLRQLARKYLREGAGASRGRELVSSLAERIPALGRLARMAGLATSRRGSGDVGGEEKALDSGPADSRDAKGPASESVPLPPPESAAAPQARELSEEPITQPGSGPRTRPARVVTFPARVKARRDPDEEDTQPLSPEAPTPRPSSSPKGDSPAAAKPAPASEPPHAAEPLVEGFFVTKMAGEKEARRHHLLEEQAPRLPPADASPERDEHLAMLPLDYQDDAMVLLARDPHTLFVFWDFSDASRNRALDELPAPRAVLKVFDGEGVSREVDFALESRSFYLQGMTPGRTYRVEAHFVGSDGRSRRIGHSSNRATLPPAGPSADTSIRFLRMPPPPVVDRLREAVPSAASARVPRVEEREYVTWRRVQLPGSAGVVDVPEVHRERTEAYVDAPRVPGASDQRYVEEAYLESAPRAPGASDQQYARVGEATLGEGAVLAPSRAPGASDQRYLAVELAPGASDQRYDVASPYLEVPRAPGASDQRYDVASPYLEVPRAPAASDQRYGQAQLPGGVSEYRYLEVPRAPGASDQRYVAGGQGTSDQRYLSVPRAAEASDQRYLSVPRAAGASDQRYLTVPRAAGASDQQYLSVPRAAGASDQRYLSADRATGASDQQYLTVPRAAGASDQRYLSVDRATGASDQQYLTVPRAAGASDQRCLSADHATGTSDQPGASRTAGGSDAWSPESPRSRGDVTEARDLPSSPPVGTSAPVGAEASFPSGPSTQGTASTDSWRPTEPEPPKDPWALSVARGPSASEQRALDKAREAARRAALASVPVSPSPAKVEAPAAMPASTPPAKAEAPTAPTPKVESRAAPSAVAPKADAVKSPPAAPSKAAQNPPEPKPSGSKSSTRSRPSRRGRK
>NC_017030.1|WP_043321833.1|6366711_6368301_-|DUF1957-domain-containing-protein
MSLGSLALVLHAHLPFVRHPEYEDFLEEDWLYEAISETYLPLLRVFDRLVEDRVPFRVTMTLSPTLVSMLNDELLRERYARRLDSLCELGAREVHRTRDDPTFHPLAVFHRDHFESLRLAYHNHYRRDLVAAFRRLQDSGHLDILTCNATHGFLPLMQQTPEAVRAQVTVAANHYRQNFGRDPAGIWLAECGYYPGLERILSAERIRYFFADTHALTDATPRPLHGPYAPIFTEPGVAAFARDPESSQQVWSTEHGYPGDPVYREFYRDIGWDLDLDYIRPFIQPTGDRKNTGFKYFRITGKTNDKQPYDPAAARERAWVHAGNFLFNRERQFEYLASRMGGRKPVVVAPYDAELFGHWWFEGPHFIDALIRQAARNPSRFTLISPLDDLREHPENQVATPPMSSWGAGGYANMWLDGTNDWIYRHLNHAARQMVELARDFPDAPSLKRRALNQAARELLLAQASDWAFIMKTGTMVDYAVRRTKEHLQRFLRLHDQVRAGTVDESWLSHVEGRNNLFPELDYRVYRPG
>NC_017030.1|WP_014397856.1|6365110_6366610_-|trypsin-like-peptidase-domain-containing-protein
MTHTLPPFRRKLVAAVLVLASPTLALAQAPAPQPPAPKTQQAASGQAGNLQPATREAQSLASLAPLVESVKSAVVNVDVQARPEMPEGMEDNPLFDRFFGGNGRGRGGRSEREQIRQGAGSGFIIDPKGLVLTNNHVIEDAVTITIRLDDGRSFTGEVVGRDPLTDVAVVKIKEKVDQLPSVKLGDSDAVRVGDWVLAIGNPFGLASSVSVGILSARAREIGASVYDDFLQTDAAINPGNSGGPLFNMKGEVVGINTAIVGGGTGIGFSVPSNLIKALLPQLEKEGAVTRGWLGVGIQPLTRELGQALKLSVSEGAILTQITPDSPAAKAGLKPDDVVVAVDGKQVRSDSELTRTVALKKPNSVATLTLYRDGKKQDVKVTMGTRPDLEGLSKKKPGATDEQDSSRRVGVSLQDLDARTASQAGFTERAGALITDIVPGSPADRAQLTPGMLVVEANKKPIASAKELAAAIRAAPKGSTLLLRVAGPGGGRLLRALTVP
>NC_017030.1|WP_014397855.1|6364452_6365046_-|SGNH/GDSL-hydrolase-family-protein
MSVNYVSLGDSTAVGVGASQGGGYPDRLASRLRKGGLPVGHTNLGQSGARVRDIVNNALKRVIALQPTLITLGVGTNDIWRGTEVAEFQDDLDRIARRLKQTGASMVVVNLADMALAPVAKMVPSALYEGRIEQFNDAIASVARSHGLHLVDLYTASREMIPRRPDFFCSDGFHPSAEGYEEWADLMLPVVRTLVRR
>NC_017030.1|WP_043321831.1|6362466_6364392_+|diguanylate-cyclase
MALGSETIGRKLLWSIALPGLVVALLGVGHFSREARQAVREGTHLEALALAEAVASTFTLPQAPGAAPHGAVAEVLASDTRLFRSVEDLRVLTPEGRIRWSRRPAEQGHPHPEASRLSATGPETARSSDHGTEVVRPLGGPECSGCHTGEAAQRMGVLQVRMGEPALTRQLQTVFQDALGAMVLFVGILGLVTWLSLRFVLTAPLKRLSEAMGRAADGDLLVRAEARGTDEISRLGAAFNQMLARLTSMKVEEIDTHRDLQLVKEKLALKDELEERLTELSLLFDVARSLNTTLELDELLSRITRMVVERLHIPDFSIMLLNEEGLLEVKHAWPQGRGLEGHTFAMGEGACGRAAQARKAVYLPDLTDSTSVFARRGLRGGSEQGSLLAVPMVHADTLLGVINFQRPETASISAEEIELFTAVADQAATAVTNARLHAETVKLTLTDALTGVPNRRHLFQRMDLELARAQRFGVPMALLMVDVDHFKRLNDLAGHRAGDETLRRVSDVLRNRARKVDTLGRYGGEEFVLLLPQVSKATAVEVAETLRRAVADSVTLSRPGLPGGHVTVSIGVAHFPTDATSQDMLVDCADSALYCSKRTGRNRVTAFEPGMEVHPGRERSISTPPADAPSTPPAPSGIAKA
>NC_017030.1|WP_014397853.1|6361491_6362250_-|peptidoglycan-editing-factor-PgeF
MTPPVFLTSELLPVPHGFATRAGGVSEGPYASLNLGFSVNDERSRVEENHRLLARAAGARLGALCRVSQVHGDRVLEARGESDDVLRPTLGEADALWTEGEGSWVAVGTADCVPVLIVDPRGKRVAAVHSGWKGTDLEISARTVETLVARGSRPEDLLAAVGPCIQACCYEVSPELGDRFRARFGPDVVRAGDKPHLDLPRAVKASLLKAGLTPEHVDVLQACTACDPDRFFSHRRDAGRTGRHLNYVLHRF
>NC_017030.1|WP_043321829.1|6360533_6361409_-|tetratricopeptide-repeat-protein
MPVRPFLFRLFAAVALSAPTACATTAASQSEVGRLEAEVRTLRASQASLLERLERLENRDAVSRARAATPAPAAASPKATASTKPEAASPEGGEALSLAPAELTVVRLKPKKEPAPRINTAVAVVEPDSDQMEMFISPVEGSNGTGSVGSISASTAARMEPPEKDPDILDAEYERAVAMLRTGNVEGGVETLTRFAAENPRHPRADNALYFSGLGQMGLKDAAGAAKTFEKLIKNYPAGDAVQDGMLRLAECRVRLNQAVDARALYTRVVTQFPGTAAATQAEQRLAALSP
>NC_017030.1|WP_014397851.1|6359293_6360508_-|LysM-peptidoglycan-binding-domain-containing-protein
MRSRILASLLVPLTVAPAWTAFAQDAQEEEPQPASETEGQDISDDVEQRPTSVTLPPGAAQGRESAPGQVHTVETGDTLWDLSQRYLGSPWYWPKVWSYNPQIANPHWIYPGNNVKFFPGGEEVPARVEGGDLPSDDVAAPTDVSGGSLVSVVGKIGYDPSKSSPVTTKGFVTTRELDEAGRIEGSTSEALMLSAPEKVYLRFKKRGAAKIGDRYVIFHTVEEVKHPVTNARTGYLTELLGTVQVVSINNDVVTARIMETWDPISRGDLVGPSSEKLSERISPKPNSKEIPGFVLTPMTPGQTLLGEHNFVVVDRGTADGVQVGNTFTIERRGDPSLDVLGRSDYKMGDAGKGQKTYPWEAVAQCMVTEVRERTSNCLMTRSMVEVSAGDRATMRKDGTPTASR
>NC_017030.1|WP_014397850.1|6358021_6359152_-|DNA-processing-protein-DprA
MADTNTDTHLHWDEQRATLALWAIAGLGPRTLDAVRAFAGGALSRLAAVPVRDWVADVPVPATVRQRLAAVASLDALASRTEEACAQSGLQVAFAGSPPYPSRLVGLEDAPPLLFYLGHPGPPRRRLAMVGSRHPDQGFLPFARTFARKVAEAGVGVVSGAAEGVDRACHWGALDVGAETWAFLGSALDALDPAQARLLPHFLERGGVYFSELPPGVRASTTTFPRRNRLISGASDAVLVMRAGEGSGALYTAEAAQAQGRPVFALPGDVWQPAAAGCNALLADGRARACTSAESICAVVGVHPVRAVPAGRDAGWWEALSAEARGAYGLLDRAPRSFDEVLAASPLSPAALTSALVELELSGLVVQHPGKRYEKV
>NC_017030.1|WP_014397861.1|6378661_6378889_-|hypothetical-protein
MWAWLKLAMAVLVVVMPGGFPLVLAYIATRTLLERWRVAQAQAREEGRPVSVVRDVVGALHFRDLIREARAATAL
>NC_017030.1|WP_014397862.1|6379079_6380021_+|MoxR-family-ATPase
MSPPQLTSEIRSFTSVEDAARRLEAVGYLSSPEIATAVFLADRMGKPILVEGPAGVGKTELAKALAQALDRTFLRLQCYEGLDEAKALYEWEYAKQLLYTQLLKDKIGELTQGTSTLAEAADRLASGDAVFFSERFLLPRPILQAQLSDTPALLLVDEIDKADPEFEAFLLEVLSDNAVTVPELGTIRAKHVPRVILTSNNARELSDALKRRCLHLHIDFPDRERELRIVRSRLPEVPQVLAEQVVEAVAAIRALDLKKAPSISETLDWAQSLALLNAEALSADIVAATLNLVLKYEGDIEKARANLPTIAQA
>NC_017030.1|WP_014397863.1|6380135_6381086_+|branched-chain-amino-acid-transaminase
MSSTSSTVLRAEHIWLDGKLMKWDEGNVHVMTHALHYGLGVFEGIRAYKTHDGRLAVFRLREHIRRLLDSAHIIMLQIPYSEDELVEATVDLLRKQKQQFANGAYLRPVAFMGDGAMGLGAVNPTRVGITAWDWGAYLGDKGIKEGIRAKVSSFTRNHVNVNMVRGKITGQYVNSILAKREAVLAGYDEAILLDISGFVAEASGENIFLVNKKGVIKTPPLSSPVLDGITRDTVLKLLRDAGHTTIEEVTVTRDALYIANEVFFTGTAAEITPVREVDNRQIGDGKPGPISKYVQDTYFRVVRGQEARYADWLTYV
>NC_017030.1|WP_014397864.1|6381145_6382483_+|AAA-family-ATPase
MPPAGYAYEDNPFKLENPSVLDIAPGEPKSLEDTGLRMGLLADLGLKFLYYAGTGTGVAIAESMCLPWSGVVEHVVDFLAAEKLVDLRGGKGFGRASVEFALTEKGREYARDALTRSTYVGPAPVPIEQYNALISSQTEETPVVGQEDLVAALGHLTVSAELMDKLGPAVNSGRSLFLYGPPGNGKTSLAEAISHMFGGEVFVPHCLEIDNQIIKVFDRIIHTPVPLEMGRDANGRRQTFEMDKRWSLCRRPAVVVGGELTLETLDLIYSESTRFYEAPFQVKANGGMLLIDDFGRQKVHPTDLLNRWIVPLEKRVDFLTLHTGKKFEIPFDQLLVFSTNLDPKELVDEAFLRRIKYKIEVGNPDEESYREIFRRVCEAAGIPYVDQAITYLVEHYYKPRSMEMRSCHPRDLVSLIRDAARYRQIPPALSKDLLDQACEVFLVNL
>NC_017030.1|WP_014397865.1|6382603_6383443_+|Fic-family-protein
MKERYQDIDEKNEQLREYLEIYKGKPPAREYLDRFEMSWIYHDAALEGVVYTHQELMAALFPERTAAEASMIPVVLEIRNHKAVADFIREEAAGAKKQSALTLTTIKRMHDLFLGNTPEALAERARMERRERTEKELAKERDRAGLRKDMPLHRTYFHDITQPAKIQARLEKLVDHTASAEFREFHPIKQAAVVQHEFLQIFPFTEHSGKVGRMCSNLILLRNGYMPAVIHSIDRQRYYESFRAPVATFRTVLMDAMENSLDNGVKYFRDLGRKYKTVE
>NC_017030.1|WP_014397866.1|6383470_6384304_+|deoxyribonuclease-IV
MRIGAHESIAGGVSQAFQRAEAHGARALQIFTKNARGWSAPALTDAETEAFRAEARRTGLPVIAHGSYLVNLAGEAPEAREKSLACVTEELTRCERLGIPLLILHPGSHPDEARGLRLIAEGLDEVHRRCPGYTARVCLEMTAGQGSALGWRFEHLEELLSRVADEARLAVCLDTCHLFAAGYDLRTPKGYAAVMDECDRRVGLHRVRAFHLNDCKKPLGCRVDRHEEPGKGAIGLTAFRCLMKDARFVDTIGVLETPFPERYGENIRLLESLCRRK
>NC_017030.1|WP_014397867.1|6384317_6385439_+|DHH-family-phosphoesterase
MPVTPSLQSRRAQLPAGSELTEPPPARLAKLPAADKLARLLQVAKGHRRALILTHDNPDPDSMAAAVSLAHLLERKAGIEAHVGYGGIIGRAENVAFVRVLRLPVSHVSQIDFSQYDLFGLVDTQPPVRNHSLPARYRADLVVDHHPLREESLLAPFADVGGDFGATSTMLVEYLRAARLEPSVEIATALFYGIKADTRDLGRETTQTDVDSYLWLFPRCDKQLLGQIEHPELPARFFQLFHTSIEKAKVYGTAIITDLEEVYSPDLVAEVAERMMYLEGMKWSLAYGTYRNQLFLSLRVKDRRMNAGRLIRELCDDLGGSSGGHGSMAGARLPLSGSASKRKALKREVVSRFLEAFGVSEERPVSLLSAQDT
>NC_017030.1|WP_014397868.1|6385435_6386581_+|cysteine-desulfurase
MIYWDHNAAAPVRAEVGALLARAFTEGGFGNASSVHGGGREARARLDAARAKVARVLGCEPKEITFTASGSEADALALVGAYAARPVKDRRRVVSTTVEHPSALGALAQLEKDGAQVVRLSPDASGRVPLEAVLEALTPDTALCSLMWANNETGVLQPVAETARACRQRGILFHTDAVQAAGKVPLTLREVDADLLSLSAHKFGGPQGVGVLVVRKGVDVRALTPGHQEGGRRGGTQNVPHAEALALALELAAADQASTAARVAALRDTFEQQVLQRLPGVTVNGAGAPRVPNTSNLRFDGVEGEALLMALDLEDIRVSSGAACASGTLSPSHVLRAMGLSPAEARSSLRFSLGPGTTSAEVTRVVDALCTHVPRVRALGG
>NC_017030.1|WP_014397869.1|6386596_6386770_-|hypothetical-protein
MATERKQQQPEQKQPTRETRHGDERLPPKADEAKEGMPGYGQPDPEVREKNLPDQKW
>NC_017030.1|WP_014397870.1|6386878_6387874_-|serine/threonine-protein-kinase
MNAPTPVSKPIRVFGNYEIQSLLGKGGMAEVYRARVRSGPYEGWTVALKRLLPALTRDPASVDLFRREAQLSRQLDHPNIVKVLDAGMLDDVSFLVMDLVDGRDLGHILRRCKARGIPLPVDFAVYLAKVLLEALAYAHTATGPDGKPLGIVHCDVSPSNLFISRVGEIKLGDFGVSRVLVDGKLQGGEVLGKPYYLSPESLQGAVTPEADLWAASVVLYELLTLGRPFVGSTPEEVFAGILSRKYRLLRSVRPDIPQALDDVLARAFAENPEDRFSSAEEYAKALSPHFDENVGTPLAIAAVVRGLFGTTDEMPAYRGSPPNGPSSDDNG

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Crispr_ID: NC_017030_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_22

6485193-6485375

Orphan

Consensus_repeat	Method
CGGAAACCTGTCCGACTGTCCGACAGGTTTTGG--AGCT	PILER-CR

2 spacers

The CRISPR arrays of NC_017030_22

>merge|NC_017030|22|6485193-6485375|PILER-CR
CGAACCTGTCCGACAGCCGGACAGGTTTTGGAGCTTCTTGGCCGCCACGGGGCCTGCGCGACGCCCGGGCCGCGGAAACCTGTTCGACTGTCCGACAGGTTTTGGAACTTCTTGGCCGCCACGGGGCCTGCGCGACGCCCGGGCCGCGGAAACCTGTCCGACTGTCCGACAGGTTTTGGAGGT

>NC_017030|22|4|6485193-6485375|PILER-CR
CGAACCTGTCCGACAGCCGGACAGGTTTTGGAGCTTC	TTGGCCGCCACGGGGCCTGCGCGACGCCCGGGCCGCG
GAAACCTGTTCGACTGTCCGACAGGTTTTGGAACTTC	TTGGCCGCCACGGGGCCTGCGCGACGCCCGGGCCGCG
GAAACCTGTCCGACTGTCCGACAGGTTTTGGAGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014397943.1\|6478317_6479787_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NC_017030.1\|WP_014397942.1\|6476859_6478137_-\|O-antigen-ligase-family-protein	unknown	unknown	gnl\|CDD\|377422
NC_017030.1\|WP_167594435.1\|6479877_6481341_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275327
NC_017030.1\|WP_014397940.1\|6475098_6475965_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_017030.1\|WP_014397951.1\|6492163_6493708_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NC_017030.1\|WP_014397948.1\|6486798_6487911_-\|YjgP/YjgQ-family-permease	unknown	unknown	gnl\|CDD\|367632
NC_017030.1\|WP_014397947.1\|6485683_6486802_-\|YjgP/YjgQ-family-permease	unknown	unknown	gnl\|CDD\|367632
NC_017030.1\|WP_014397955.1\|6497175_6499944_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_043321854.1\|6471632_6472817_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NC_017030.1\|WP_014397949.1\|6487907_6489167_-\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NC_017030.1\|WP_014397945.1\|6481581_6483942_+\|phosphoketolase-family-protein	unknown	unknown	gnl\|CDD\|235379
NC_017030.1\|WP_014397938.1\|6472939_6473848_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176169
NC_017030.1\|WP_014397950.1\|6489168_6492159_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|274350
NC_017030.1\|WP_014397956.1\|6500045_6500354_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014397946.1\|6483938_6485114_+\|acetate/propionate-family-kinase	unknown	unknown	gnl\|CDD\|234680
NC_017030.1\|WP_014397952.1\|6493814_6494306_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|223642
NC_017030.1\|WP_014397941.1\|6475997_6476807_-\|DUF3472-domain-containing-protein	unknown	unknown	gnl\|CDD\|378772
NC_017030.1\|WP_014397953.1\|6494363_6494888_-\|MerR-family-transcriptional-regulator	unknown	unknown	unknown
NC_017030.1\|WP_014397939.1\|6473946_6475059_+\|keratin-associated-protein-10-2	unknown	unknown	gnl\|CDD\|368175
NC_017030.1\|WP_083892327.1\|6495052_6497155_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014397943.1\|6478317_6479787_+\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.71771e-68
NC_017030.1\|WP_014397942.1\|6476859_6478137_-\|O-antigen-ligase-family-protein	gnl\|CDD\|377422	pfam04932, Wzy_C, O-Antigen ligase. This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.	1.65988e-10
NC_017030.1\|WP_167594435.1\|6479877_6481341_-\|hypothetical-protein	gnl\|CDD\|275327	TIGR04534, hypothetical_protein, ELWxxDGT repeat. This model describes protein repeat with a well-conserved motif ELWxxDGT, and a periodicity of about 48. A single protein may have as many as 18 repeats. It may consist nearly entirely of this repeat, or may have other repeats as well (e.g. hyalin repeat). It is most common in the Deltaproteobacteria.	8.84888e-15
NC_017030.1\|WP_014397940.1\|6475098_6475965_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.89133e-06
NC_017030.1\|WP_014397951.1\|6492163_6493708_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NC_017030.1\|WP_014397948.1\|6486798_6487911_-\|YjgP/YjgQ-family-permease	gnl\|CDD\|367632	pfam03739, YjgP_YjgQ, Predicted permease YjgP/YjgQ family. Members of this family are predicted integral membrane proteins of unknown function. They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this.	8.91419e-79
NC_017030.1\|WP_014397947.1\|6485683_6486802_-\|YjgP/YjgQ-family-permease	gnl\|CDD\|367632	pfam03739, YjgP_YjgQ, Predicted permease YjgP/YjgQ family. Members of this family are predicted integral membrane proteins of unknown function. They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this.	1.08939e-58
NC_017030.1\|WP_014397955.1\|6497175_6499944_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.3788e-98
NC_017030.1\|WP_043321854.1\|6471632_6472817_-\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	9.16583e-91
NC_017030.1\|WP_014397949.1\|6487907_6489167_-\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NC_017030.1\|WP_014397945.1\|6481581_6483942_+\|phosphoketolase-family-protein	gnl\|CDD\|235379	PRK05261, PRK05261, phosphoketolase.	0
NC_017030.1\|WP_014397938.1\|6472939_6473848_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176169	cd08480, PBP2_CrgA_like_10, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 10. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.52517e-93
NC_017030.1\|WP_014397950.1\|6489168_6492159_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	1.28528e-20
NC_017030.1\|WP_014397946.1\|6483938_6485114_+\|acetate/propionate-family-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	1.21386e-149
NC_017030.1\|WP_014397952.1\|6493814_6494306_-\|DNA-binding-protein	gnl\|CDD\|223642	COG0568, RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription].	3.70149e-07
NC_017030.1\|WP_014397941.1\|6475997_6476807_-\|DUF3472-domain-containing-protein	gnl\|CDD\|378772	pfam11958, DUF3472, Domain of unknown function (DUF3472). This presumed domain is functionally uncharacterized. This domain is found in bacteria, eukaryotes and viruses. This domain is typically between 174 to 190 amino acids in length. This domain has a single completely conserved residue G that may be functionally important.	0.000275384
NC_017030.1\|WP_014397939.1\|6473946_6475059_+\|keratin-associated-protein-10-2	gnl\|CDD\|368175	pfam04885, Stig1, Stigma-specific protein, Stig1. This family represents the Stig1 cysteine rich plant protein. The STIG1 gene is developmentally regulated and expressed specifically in the stigmatic secretory zone.	0.000271862
NC_017030.1\|WP_083892327.1\|6495052_6497155_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.25561e-91

>NC_017030.1|WP_014397946.1|6483938_6485114_+|acetate/propionate-family-kinase
MSDPGAVLVINSGSSSLKFGLYVEQGGQESVRFKGSATHIGAEQGRLVVKDGTGKQVRAVDVRHPSQEDAFREAVWHLGELGGERPRAIGHRVVHGGPHLRAHQALTPEVMKALEEATHFAPLHIPAALRLIRATERQYPGVPQFVCFDTAFHATLPEVASTFPLPRSVRDQGVQRYGFHGLSYESIVARLEPQVPARTVVAHLGNGASLVALDHGRSVDTSMGFTPTGGIPSGTRTGDLDPGVLLFLMRTGGMDADALETLVNHDAGLRGLSEGTSDMQALTRDAAAGNTAAALAVDVFTRSIAKTVGAYATVLGGLDLLVFTGGIGENSARIRESVCARLGHLGIQLDAQRNEAGEGLITAKGSRCPVRVLPSDEEIQLARHTRRLLRG
>NC_017030.1|WP_014397945.1|6481581_6483942_+|phosphoketolase-family-protein
MAGPLSDEELGKIDAYWRAANYLSVGQIYLKDNPLLERPLTREDIKPRLLGHFGTTPGLNFIYVHLNRIIRNHRANMMYLIGPGHGAPGIIANTFLEGSYTELYPNIERNRDGMKRLFRQFSWPYGIPSHDAPEVPGSISEGGELGYALLHAYGAVLDNPDLIVPCVVGDGEAETGALAASWHSNKFINPITDGAVLPILHLNGYKIANPTVLARIDADELEALFKGYGHTPYVLEGDDPKDMHQRMAQVLDTLYAEITRIQRHAREKNDPTRPRWPMLVLRTPKGWTGPKVVDGKPVEGTWRAHQVPLEEVRDNPEHLKILEAWLHSYRPRELFDANGTFREELADIAPKGRLRMGVNVHSNGGQLLVPLVLPGFRDYAVDPGVPGSRQVSATKVLGGYLRDVMRHNLATKNFRMFAPDENASNRLQDVYAVSGKSWDAKQESTDENLSVDGRVMEVLSEHLCQGWLEGYLLTGRHGFFSCYEAFIHIIDSMFNQHAKWIKSAKELPWRKPIASLNYLLSSHVWRQDHNGFSHQDPGFIDHVANKKADTVRIYLPPDANTLLSVTDHCLRSKNYVNLIIAGKQLSPVWLDMASAVRHCSAGIGAWDWAGNDDGDPDVVMACAGDVPTMETLAAVTLLREWAPELKVRVVNVVDVFTLAPVHVHPHGLNEEDFNRLFTTDKPVVFAFHGYPTLVHKLTYNRANHGNIHVHGFKEEGTTTTPFDMTVLNDMDRFTLALDAIRHSKAARHRLDDAEQRFSEVRQRHKLYVSEHGEDMPEVADWKWSAR
>NC_017030.1|WP_167594435.1|6479877_6481341_-|hypothetical-protein
MRFGWILAGLSFVGCGGAQEMAPPSAQEPQVQAQACTPAMAATKVKDFLAPGDPLPSPYRPIPEWLTNVAGTLYFTSDPYQGTAALWRSDGTTVGTVPVKEFPYAGLNYRDFASLTAVGSRVFFTMEDPAVGSELWVSNGTAAGTQLVKDITPGAPGSFLSNLTALGGALTFFRNAGGAVELWRSDGTAAGTYRVVDFGAGSSRAYPTLHAGGALLFFLQDATQGTRLWRTDGTAAGTWLVKRVDAGGPYVTATRGLASGTGVFTLDDSSGTEVWRTDGTAAGTVRLDTFGKQARLLGSLGSYVYLSTLADDGERLKLSRLSLSGGGKTTVTTLPNPYPGQPDNTPYVQDSQESGGKLYLSVAISSPGPAPRQVGLWVTDGTAGGTRQLSQELTTADEYSSPLFDTGSGTLLFSSFEGDLGLMPQVTTGTPAGTGRVTTSSPGGERPEEFTRVGNTIYFRAYSGVWGSALWAVPANVTCTPLSASAR
>NC_017030.1|WP_014397943.1|6478317_6479787_+|MFS-transporter
MRTTHRPFTTLALALCLFVAALEMTVVSTAMPTVVSDLGGIQHYAWVFTAYMLSSTITVPIYGKLADLYGRKPILLFGSTLFLLSSLACGFSTSMNMLIAFRVLQGLGAGAMQPIALTIIGDIYTLEQRGKVQGAFSAVWGIAGLAGPLTGGLIVKYLTWHWIFFINIPIGIASMVLIVLFFHEQLQRKERARLDYAGAALLSSGVVALLFGVQGSGATLLALPVAAVLLTAFVFVELRAAEPIIPMSIFKIPTIAISNVAGALFSAAQFGATTYVPLYVQGVLGGSATMAGGMITPMIVGWPLASLIGGKVMVRTGFRPLIVGGLGLASIGTVLMALLLKPGASMLVPQIAMGLFGIGLGFAAMATMVAVQTTVGWELRGVATASSMFFRTIGGSLGVGVMGGVLVNQLMKDPNVPVSAATELLGPEHGRGLAPAILETLGGALNTGLSINFWIMCSAMIAAFTAGLFFPKVKRVTTPVNMSDVTASH
>NC_017030.1|WP_014397942.1|6476859_6478137_-|O-antigen-ligase-family-protein
MGTDTKTVESGRWKTAVAAVLGLYAVGLVLAEAVLQAGAILATALALALAVTKRLRLEKDVRAFVLASVALCAWQLLSPAVALLTGAATKWPRGARYGQALDTVAAAAVACIGTLGVPWLMLGSLIAGGWLLAAALGFFQHRVPWPWEPPKFTKLNLARLHENFGTEENPRYAAGGFFFHRLKFAHGAIAVLGPALAVIGRSKVTRRRVLAGVMVLGLLLSIYGAFARAALGAALGVCVLALLLLLRGTARKAGLGVAVALVAVVLLTPAWRERFGKALDNLFGSGERSLAMSVGWRLVREHPWVGVGFGNHKPAALATQAETGITDLLATDSHNLWLTAWAETGLVGLVLLATMHFLLARALVRRHRAGSIPATGALLSFVGFHVLALVHYLPFHPSVHLSFMLIWGLGLCGYSQDSQESVKSA
>NC_017030.1|WP_014397941.1|6475997_6476807_-|DUF3472-domain-containing-protein
MTRFLQVLTPFCLGSLLACGGTDPQATQPEPRTLATTSQSLVKVNQTYSYWDVQNVPAQGLYNFDLTIFPSNDPAADATHVAPWYFYAAQFAFKTGGDAGYIGIQTDPNGKRAVFSIWGANGATCSNVSGAICQPFSHEGVGYQTMVPFNWVAGQYYRVRVWQNGADAEGEWWLGVIINDSTQTETVVGRIRVPWGRNWLSGSIINWVEWYGPGTDNCTQLTSSTVYFAPPKGNAGTLTAPPPYNTTGQGPCASDVSVYGEWMRHYNGW
>NC_017030.1|WP_014397940.1|6475098_6475965_-|GNAT-family-N-acetyltransferase
MDAHTVTRIGSHDKDLQELFCDYVPQVFRRADFRRWRAWGQWSDDYHAYALMEAGRVVANTSVMRMRLVLEGREVTGYQLGAVGCLPSHRGRGLARVAMNAALDACGDAPVLLFANPTVRQFYPRFGFQPQRQTLFTTTYDSVPEGPPALTLNLDDEEVRAGLVALSSEGLPSTERFGARGYATVASWPVANGFARPLRQLGSEAWVFAGVEGETLYLDDVFAREPFDLRAWIPRLIDRPIRAIRFGFTPERYWPGAVEAGEDTEADLFVRNLQLSPEAHRFPIMAHT
>NC_017030.1|WP_014397939.1|6473946_6475059_+|keratin-associated-protein-10-2
MISIRSIALSCFVVLGIFAACSDDSPNPPGGAPDASVPDASVPDASVEMCTDAGTTQCGDTCVSTDSDPAHCGGCGQACASIEACESGVCVSVCRIDGQQIAAGTLNAANACEQCTPATSATAWTQLAEGAECGVGQVCSAGACSPKCFINGTIYGEGTPNPANACEVCTPAMSTTAWSPREAIPLLVGGTDIVAQGWTTISQAPSTLTYGEDYVRLATSTNSGARTSGQLLLAKTNALDPTQPFKLRVTMQVESVNTHNQLDSGAAILGSFTSPSGNSTDRTQMIYLDSRAIGWADDTQSAAFAVTDGAYHVYELAVDASKVATVSVDGVAKLTRNNFTASGTIAIGDQTNDPNVDGVVRIKSVEKLCQ
>NC_017030.1|WP_014397938.1|6472939_6473848_+|LysR-family-transcriptional-regulator
MNAKVQPGGADRAHEMAVFSAVVATGSFSAAGRELDLSPSAVSRTLDRIEARLGVRLMLRTTRALTLTPEGHAYLRAARRILAELDDAEQAIADLGAPRGRLRVSAAHSHGRLCVVPLLGDFTARYPHILVDINLTDRVVDIAAGQADVAIRFGPLADSGLTARKLGENPRVIVASPDYLARRGTPMVPEDLHHHNCLNFNFRRAEAVWPFVRDGHEYSLSVKGSIEANNGETLGQLAAAGVGVARVGAFSVAEELRSGRLVPLLEQYNPGDVENIHAVFVGGANLPARVRVFVDYLADALR
>NC_017030.1|WP_043321854.1|6471632_6472817_-|MFS-transporter
MKPNAPLLALAVGAFGIGVTEFAPMGMLPVIAEDLGVSIPAAGLLVSAYAFGVLVGAPVMTLTTGRVPRRTLLVGLMGIFTLGNLLSALAPEYWTLMAARVVTSFNHGAFFGVGAIVAASVVAPNRRAGAVAAMFMGLTVANITGVPLASWAGESLGWRASFWGIAGLGALAMVALRLTLPHGQVEPSSDSGAMKAELAVLRRGPVLAALALTVIGSSAMFTVFTYIAPILKEQTLASAGFVTAMLMTYGLGLTIGNWLGGRFADRSVDRTLIVTLAGLATLLVVFAGVMPWQAPAAVVIFLWGVASFALVPPLQMRVMTAASDAPNLASAMNIGAFNLGNAIGAALGGAVIGLNLGYPAVALAGAAMAGAGLILVLLLVRREARVVTALPARC
>NC_017030.1|WP_014397947.1|6485683_6486802_-|YjgP/YjgQ-family-permease
MRGTLFRYVVGAYVRYTLGILAGVVAVFLVVDFVDRAKAYGGEGWVLDVLKLYGYKALVTVQQLGPAALLLAAGTTVSALRKKGEVTALRSLTFGPAALYLPVGICALVACVGLVAFDETVAARAGRRVDEITTQRFNRWGDWRMYYTPKQWFRRGDSIFFLRGGNPQEGFENVSIFTLTPEFKLRRRVDAGRMRSVEGTRWELTDVVERTFTEDGRTSVTQQPVAEYELGVGATTFRIRPGRPEQMRLGELGEQIVARAEVGLATKAFQLAWHNRFAYPLAGLPAALLAVGLALRTNRRGHLTAAVVEGLLIAVAMWGLMVVSRTLVLTERLAPAVAAWMPTTLLTVVAAALWLRREGLLHFPRRSVTRQA
>NC_017030.1|WP_014397948.1|6486798_6487911_-|YjgP/YjgQ-family-permease
MKLLARYLLKELLVPLGVWVAFMFLLLFVMQFLRGTDVLLGSAVTLVDLGRLIAYLAPHFLVMALPIAFLLAILLGLGRLGEDRELTSLQALGISPLQLLAAPLGVGIALSAFMVLLTSTVEPWGLTGVKDLVGEVIQKNVAGDVKSGVFYEDLSDLTLYAQKVAPKGGGWTNVLLHDDRDPSSPLLVLAHKGSVGTSERGEALRIELKEGEVHRANRSSVDASVVAFEKAEINVGLGGSLSRRNRFRSPKEELTPAELLAAAKDAEERREDSRPFLMALHSRMGNAVAPVAFALLGTPLAIGRRQAGRAWGYLLTLGGYVLYYLLSRAFEQMGQKGQMPVFVAGQLANVLFMVVGAFALYRVTRSGTVR
>NC_017030.1|WP_014397949.1|6487907_6489167_-|phosphoribosylamine--glycine-ligase
MKVLLLGSGGREHALAWKLAQSPRLSRLLVGPGNPGTARWGTNVPLQADSPEAVVSLARRERVDLVVVGPEAPLVAGVADALAQVDIPCFGPVAAAARIEGSKAFAKEIMAEAGVPTAAFRVFTDAAEAEAYAVAQGRIVVKADGLAAGKGVIVAPDAKAAREAVRAVAEMGQAGQRMVLEELLEGEEVSLMALCDGERYVLLPLSQDHKRVGEGDTGPNTGGMGAYCPAPFLTPAQLAQVGEQVIAPTLAVLKKRGTPLRGVLYAGLMLTASGPKVLEFNARFGDPETQVLMMQVDEDLLPLMEACAKGTLEPRPLKQFPGASVGVVLAAEGYPEAPKKGARIEGLDAVASNAPVFLAGVAKQDGALVTAGGRVLTVCARGDSLATARERALESADAVRFEGKHFRRDIGARGLRARP
>NC_017030.1|WP_014397950.1|6489168_6492159_-|zinc-ribbon-domain-containing-protein
MRIVCQKCAAAYAIDDRLITPKGVRAQCPRCRHLQLVKREASAASVTAPAEGAVPPSAEPKPPAAAPAPPVAREPRSNPAAAPVAAKPLEPLAAPKAAPKSDLFGDFGEMPELGPPGSVDPFADLGPPASKAPGGLPSDPFANLGPSVPPSASKAAPAAKPGPPVPAAPAVAAPAKSAAPVVPEDPLLDFLGPAPGGLEPEASPAPGRASSPPAGAVSLGRMSARAPAPVVPKPETHTNCRSCGKDLTDPFDQALGICEACKQRESAFPRESTVLVAPEVAPPPSDGGALVELPVMSGLDGAASGDEPRSEGATALAPDSRVSSVKPARTSHITAAPVRSAQRGGSGGSRAGVFSLLALAVLGAGGAGYYFLVHKPQQEQRVRDAQPAAPAAVPPEVLATVGRWKLQFLELEGTSEQHLAAGQKQLAMDQRSAYAEAEESFQQALLLDPRSTDAIAGYVQALALGRGPGMDDNSFQEARELIQAATGMAGETPALLVAHANLLLARSRQAGNLEEAARLATEVLSQSNAADAYKAEAHLVLGRSQVATSRELANQEFEAARKLAPNLQRVDYYSALAHEQAGQYGMALKQLRQRMELDPQDWNSVEAAARIYVEVGETARARKLYEDRLKAKAGDVRATLALAVLRYQAEGNAREAVRVLKELSKNASRHGPRDASEIFSHLAAAERTAGNDAAAATAAAAALKAVPAMPEAHLQWFMVALTQKDAALAREHLKGFQGRLEDAALEKVLEGRVHLLEGDAAGAQARFQQAVRLDDRRMDAKLLEGVAAASAKKRDEAFRLFYPVLEARVWDPLRLAPRPALSRFWLRPGDTLVGVENVVKSLGDRAEDVQPLLYEALVRFHQGDRQTAERLLQSVVDVNANSGGALAYRALIALDTKGPQARNLADRAVGVERGLPVARLSLGLAQAAAGDVAGAMRALQSTLDVAPKMLSAQTKLAELLVTSKPQEARAVLEKVVGLDPSYFPAKKLLFKLDERG
>NC_017030.1|WP_014397951.1|6492163_6493708_-|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MLALLSVSDKRGLVPFAQGLVRLGYRLLSTGGTLEALKAAGIPATQVSEHTQSPEILGGRVKTLHPRIHGGILGRPDLESDKAEMAANHIEPISLVVVNLYPFRQTVASGAGEDDVIENIDIGGPAMVRASAKNFKHVAIVVDPDDYAPVLAEIEGHKAVGLETRRRLMRKAFAHTAAYDASISGWLSGEAQEPFPEELSLAFRKVQGLRYGENPHQRGAFYKEYAAPKEPSVAFAKVLQGKELSYNNILDLDAALGLVLEFPEKPCAVVIKHNTPCGVAVDDVLEKAYRTARAVDEVSAFGGIVAFNREVDEATAKAMAETFLEAVIAPSYSAVALQVLAGKKNLRLLEAGPALASPTAAPRPQVDARSVSGGMLLMDRDAVEPPLEWKVVSKRAPTPEEERALRFAWKVCKHVKSNAIVFAAPAQLLAQGGGQTNRVDSVRIAMTRGGEALKGSAVASDAFFPFRDGLDEAARAGATAVIQPGGSVRDAEVIAAADEHGMAMVVTGVRHFRH
>NC_017030.1|WP_014397952.1|6493814_6494306_-|DNA-binding-protein
MSEVKQLQEGEGGNEEEQPAERRRSKTMSRKEMARDLRRRRLAGQLDPEEAETLKLVDEQRPRTRADCINGPRPCLFVSCKHNLYLDVNPETGSIKLNFPDKEITELEHTCALDVAEKGGITLEEVGEIMNLTRERIRQVETRGLMKLREATEAEPPVSARKP
>NC_017030.1|WP_014397953.1|6494363_6494888_-|MerR-family-transcriptional-regulator
MESMDLLAPEELERIERENAGGLPANAILEIFRPRGVRLSEATFRKYVQAGLLPRSRRVGRKGKHQGSLGLYPVEAVRRINVIKKMMAEGHTLEDIRRSFVFHRNHIDQLQRDLSEVLDGFQEELGGRPLGGERRRSLEAQLATLRQRAQDLVRDVARLGSAVTAREDETLRPQ
>NC_017030.1|WP_083892327.1|6495052_6497155_-|serine/threonine-protein-kinase
MTLEAGTHVGKYVVRRKLAEGGMAEIFLCTARGPEGFEKEVVIKRVRAFLASDPDFVQMFIAEARLASRLNHANVVQIFDFDKHEDTYYLAMEYVRGCSLWELRKRSKEAMTPMPPVLVAHIGAEVARGLHYAHRLRVNGELLNLVHRDVTPHNVLVSYDGAVKLTDFGIAKAGNKLTNPGVLKGKFAYMSPEQARGESVDVRTDVFALGVVLWELLTGGRLFQGDSEIAVLRAVQESTIVPPARLNPDVPPDLDAAICRALERDLSKRFQTAGELERALAQCVLNHARSVDDTDVGAFVRPLFPVAASNQALPALPERTALQDGALPAEGAPPREPTAVMPSREHASGAKQGASPDEDRHGTTLVLSRDDQAPNARPPQPTPQMPLQSMGREAPLARRSESREVPAARAESPSDENSMAWTGFADDDVGAPEDGGSRSSASARRREESSSRKPDTASARRAGSAGNADSASARRVELDGDDLSGADDRELDTVSATEPGPPVAPGRKRALWAGAAALGLAGLVGVLAVARSNTGARDAGQGSPPAQATTAAATPPPTTAPAVTPPPATSAVPPAESARTPAAETVDAELEGQRREAALAPAPSTETAAPATTPTADPATEPPAADSAKAMGTLHVKATPYATVYLGAKRLGDVQGRATYKVPAGTYTVTFQHPTSKKAFTVVVPADGSVLQEFRASRGR
>NC_017030.1|WP_014397955.1|6497175_6499944_-|protein-kinase
MSIETYGSYQLLKRLATGGMAQIYLARRPGSDAPDKLLVLKRILPHLSENDEFVRMFLDEARIAARLAHPNVVQIYDLGAEGDTFFIAMEYIHGVDARRLWKRSETAGRPLPVPIVCRILLEACAGLDYAHKKTDAAGRPLGIVHRDVSPQNILVTFDGGVKVVDFGIAKAADQATVTRSGVLKGKYSYMSPEQAAGQRVDRRSDVFALGVVLHELLTGGRLFKRVSDMLTLSAVAECNVPVPSQVAPRVPVELDAIVLKALAKDPDARYQHAQELQRALEGWLASQPQPCGTPADLAGYMRELYSDRLTEEARSGEVQVTDEEAGVAPPSAPRRSVMRPATAPARTENEPTTTLRPNRPSRPSGKVEARREDAEADGARSEVRGPDTRPEGRNAEARMEARNSEGRGVDARPEPRSEVRNAEARSVDARAVDARPEPRSEVRNADPRAEASRGMTGSRRALESPPSRSTRPVRLEEPSLPTVTQDEDGPTLAMVDTQRKLSGGFQIEEDGPTLAMVDTEGKLSRGFQIEEDGPTLAMVDTQGKLSRGFQIEEDGPTLDQRSMTTLTQDDEDDSTLDMRAVSRADVDEGPTQDLRAVPRSEIPVPRPGGPTPSGEHRGHRLPVPAPHATIEEMTASTAPRSASRAPMPNAWVPPARTGTLTEQSAVERPKRRGLLYGAIVLVAILVGVGIVWSLGPGASGVHVESEPEGARVVFEDRVLPERTPLTLPTVKPGRYWVVLIKEGYRELRTQIVIPPSGRLDVGPLKLVPLPPSGKPGAEPPATAPPPPSTTPEPGVGPSGVAGPHAPDARAPEVKQAQESPGAQAPAPVVKAPVASAATVVPAAEVREAARAAERSAPVSFVVTPRAEVSCNGRKLGETPFQPVKLGVGLYDCKFTHPELKRTVSRRIEVRPIDLNVVTVKFE
>NC_017030.1|WP_014397956.1|6500045_6500354_-|hypothetical-protein
MKSSPRAGAPGLRVIRGEGQRKQEPLADRNAVARVLMEAGADLLLRRISPVRAQEIERKVDRVLDLFDRVDAAPVLMPVLKRHLDELEALMRETREVRAARR

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Crispr_ID: NC_017030_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_23

6590410-6590608

Unclear

Consensus_repeat	Method
CTTCCCGTTCTCGTACCAGAAGGTCCAGAGCCCCTCCTTCTTGCCGTCCTTGAAC	PILER-CR
AGGTCCAGAGCCCCTCCTTCTTG	CRISPRCasFinder

2 spacers

cas3

The CRISPR arrays of NC_017030_23

>merge|NC_017030|23|6590410-6590608|PILER-CR,CRISPRCasFinder
CTTCCCGTTCTCGTACCAGGAGGTCCAGAGCCCCTCCTTCTTGCCGTCCTTGAACGTTCCCTCGGACTCCAGCGCTCCGTGTGAGGACCAGAAGGTCCAGAGCCCCTCCTTCTTGTCGTCCCGAAAGGTCCCGGTGGAGTGCCTCTTTCCGTTCTCGTACCAGTAGGTCCAGAGCCCCTCTTTCTTGCCGTCCTTGTTC

>NC_017030|23|5|6590410-6590608|PILER-CR
CTTCCCGTTCTCGTACCAGGAGGTCCAGAGCCCCTCCTTCTTGCCGTCCTTGAAC	GTTCCCTCGGACTCCAGCGCTCCGTGTGAGG
ACCAGAAGGTCCAGAGCCCCTCCTTCTTGTCGTCCCGAAAGGTCCCGGTGGAGTG	CCTCTTTCCGTTCTCGTACCAG
TAGGTCCAGAGCCCCTCTTTCTTGCCGTCCTTGTTC

>NC_017030|23|18|6590430-6590596|CRISPRCasFinder
AGGTCCAGAGCCCCTCCTTCTTG	CCGTCCTTGAACGTTCCCTCGGACTCCAGCGCTCCGTGTGAGGACCAGA
AGGTCCAGAGCCCCTCCTTCTTG	TCGTCCCGAAAGGTCCCGGTGGAGTGCCTCTTTCCGTTCTCGTACCAGT
AGGTCCAGAGCCCCTCTTTCTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_043321873.1\|6590895_6591168_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_017030.1\|WP_014398035.1\|6613101_6613515_-\|preprotein-translocase-subunit-SecG	unknown	unknown	gnl\|CDD\|273280
NC_017030.1\|WP_014398019.1\|6580383_6580569_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398021.1\|6581593_6582859_-\|lanthionine-synthetase-C-family-protein	unknown	unknown	gnl\|CDD\|271201
NC_017030.1\|WP_014398023.1\|6583971_6585375_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|225130
NC_017030.1\|WP_014398018.1\|6576994_6580228_-\|lantibiotic-dehydratase	unknown	unknown	gnl\|CDD\|377403
NC_017030.1\|WP_014398029.1\|6595444_6598027_-\|BREX-2-system-phosphatase-PglZ	unknown	unknown	gnl\|CDD\|380288
NC_017030.1\|WP_014398033.1\|6607675_6611764_-\|protein-kinase	unknown	unknown	gnl\|CDD\|380284
NC_017030.1\|WP_014398017.1\|6573023_6576950_+\|Dyp-type-peroxidase	unknown	unknown	gnl\|CDD\|376958
NC_017030.1\|WP_014398030.1\|6598023_6601650_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380283
NC_017030.1\|WP_014398031.1\|6601666_6603670_-\|DUF2326-domain-containing-protein	unknown	unknown	gnl\|CDD\|378384
NC_017030.1\|WP_014398020.1\|6580684_6581590_-\|MsnO8-family-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NC_017030.1\|WP_014398032.1\|6603666_6607665_-\|BREX-2-system-adenine-specific-DNA-methyltransferase-PglX	unknown	unknown	gnl\|CDD\|380293
NC_017030.1\|WP_014398016.1\|6572119_6572671_+\|transposase	unknown	unknown	gnl\|CDD\|315923
NC_017030.1\|WP_014398028.1\|6594074_6595445_-\|BREX-system-ATP-binding-protein-BrxD	unknown	unknown	gnl\|CDD\|380280
NC_017030.1\|WP_014398034.1\|6611767_6612517_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_148282353.1\|6582857_6583958_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NC_017030.1\|WP_014398024.1\|6585381_6587595_-\|peptidase-domain-containing-ABC-transporter	unknown	unknown	gnl\|CDD\|225183
NC_017030.1\|WP_014398025.1\|6587587_6588535_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NC_017030.1\|WP_014398027.1\|6591318_6594072_-\|DEAD/DEAH-box-helicase	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224122

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_043321873.1\|6590895_6591168_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.63655e-07
NC_017030.1\|WP_014398035.1\|6613101_6613515_-\|preprotein-translocase-subunit-SecG	gnl\|CDD\|273280	TIGR00810, secG, protein translocase, SecG subunit. This family of proteins forms a complex with SecY and SecE. SecA then recruits the SecYEG complex to form an active protein translocation channel. [Protein fate, Protein and peptide secretion and trafficking].	6.11468e-24
NC_017030.1\|WP_014398031.1\|6601666_6603670_-\|DUF2326-domain-containing-protein	gnl\|CDD\|378384	pfam10088, DUF2326, Uncharacterized protein conserved in bacteria (DUF2326). This domain, found in various hypothetical bacterial proteins, has no known function.	4.50143e-09
NC_017030.1\|WP_014398021.1\|6581593_6582859_-\|lanthionine-synthetase-C-family-protein	gnl\|CDD\|271201	cd04793, LanC, Cyclases involved in the biosynthesis of lantibiotics. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links called lanthionines (Lans) or methyllanthionines (MeLans) in addition to 2,3-didehydroalanine (Dha) and (Z)-2,3-didehydrobutyrine (Dhb). These unusual amino acids are introduced by the dehydration of serine and threonine residues, followed by thioether formation via addition of cysteine thiols, catalysed by LanB and LanC or LanM. LanC, the cyclase component, is a zinc metalloprotein, whose bound metal has been proposed to activate the thiol substrate for nucleophilic addition. Also contains SpaC (the cyclase involved in the biosynthesis of subtilin), NisC, and homologs.	5.88928e-86
NC_017030.1\|WP_014398023.1\|6583971_6585375_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	9.66461e-08
NC_017030.1\|WP_014398018.1\|6576994_6580228_-\|lantibiotic-dehydratase	gnl\|CDD\|377403	pfam04738, Lant_dehydr_N, Lantibiotic dehydratase, C-terminus. Lantibiotics are ribosomally synthesized antimicrobial agents derived from ribosomally synthesized peptides. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues. This family constitutes the N-terminus of the enzyme proposed to catalyze the dehydration step, via glutamylation of the substrate during lantibiotic biosynthesis. The enzyme dehydrates Ser/Thr residues in the precursor by glutamylation.	0
NC_017030.1\|WP_014398029.1\|6595444_6598027_-\|BREX-2-system-phosphatase-PglZ	gnl\|CDD\|380288	NF033446, BREX_PglZ_2, BREX-2 system phosphatase PglZ.	6.53459e-60
NC_017030.1\|WP_014398033.1\|6607675_6611764_-\|protein-kinase	gnl\|CDD\|380284	NF033442, BREX_PglW, BREX system serine/threonine kinase PglW. Members of this family are PglW, a predicted serine/threonine kinase of the Pgl (phage growth limitation) system (now called BREX type 2) and the BREX type 3 system.	1.69077e-76
NC_017030.1\|WP_014398017.1\|6573023_6576950_+\|Dyp-type-peroxidase	gnl\|CDD\|376958	pfam02901, PFL-like, Pyruvate formate lyase-like. This family of enzymes includes pyruvate formate lyase, choline trimethylamine lyase, glycerol dehydratase, 4-hydroxyphenylacetate decarboxylase, and benzylsuccinate synthase.	1.14685e-118
NC_017030.1\|WP_014398030.1\|6598023_6601650_-\|hypothetical-protein	gnl\|CDD\|380283	NF033441, BREX_BrxC, BREX system P-loop protein BrxC. BrxC is a P-loop-containing protein, and probable ATPase, from BREX (bacteriophage exclusion) systems of type 1.	6.16729e-08
NC_017030.1\|WP_014398020.1\|6580684_6581590_-\|MsnO8-family-LLM-class-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	3.96861e-69
NC_017030.1\|WP_014398032.1\|6603666_6607665_-\|BREX-2-system-adenine-specific-DNA-methyltransferase-PglX	gnl\|CDD\|380293	NF033451, BREX_2_MTaseX, BREX-2 system adenine-specific DNA-methyltransferase PglX. This protein, PglX, is a site-specific DNA methyltransferase associated with PGL (phage growth limitation), a type 2 BREX (bacteriophage exclusion) system. The phage resistance appears not be restriction, but does manage to inhibit phage replication.	0
NC_017030.1\|WP_014398016.1\|6572119_6572671_+\|transposase	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.11028e-11
NC_017030.1\|WP_014398028.1\|6594074_6595445_-\|BREX-system-ATP-binding-protein-BrxD	gnl\|CDD\|380280	NF033438, BREX_BrxD, BREX system ATP-binding protein BrxD. BrxD is an ATP-binding protein found in types 2 and 6 of BREX (bacteriophage exclusion) phage resistance systems.	6.78347e-172
NC_017030.1\|WP_148282353.1\|6582857_6583958_+\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	7.11283e-35
NC_017030.1\|WP_014398024.1\|6585381_6587595_-\|peptidase-domain-containing-ABC-transporter	gnl\|CDD\|225183	COG2274, SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms].	0
NC_017030.1\|WP_014398025.1\|6587587_6588535_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	1.05771e-11
NC_017030.1\|WP_014398027.1\|6591318_6594072_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|224122	COG1201, Lhr, Lhr-like helicases [General function prediction only].	9.60313e-132

>NC_017030.1|WP_014398025.1|6587587_6588535_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MSDSPRTVFRQEALEHHARPEARGGLLRLMPGWIHATWWVVVGLVVVGGVGLSLVEINDYARGPVLVRVKGLEEVTSTEGGRVSRVLVRRGERVHAGQPLVELYAGGETAERERVDQEFRSQLAAWLLEPANPGTRQALAGLRAQLELSEARMSERVLKAPCDGRVGEVRVREQQFLQPGEVVASLVRDGAETWAVALLPGQYRPLLHPGQPLRLELTGFPYSYQMLEVASVSDDLVGPAEVRRLLGPGLKDALTVTDGPLVLVEAKLPSETFHTGDDTYAYFTGMPGQAWVKVRARNGWVTLLPVLELFGKRRG
>NC_017030.1|WP_014398024.1|6585381_6587595_-|peptidase-domain-containing-ABC-transporter
MAEPSPSFFERFPALGRLGEQLGRRRIPYVAQLAAADCGAACLAMVLGYWGRHVGLDEVHAATGLTTRGISARTLLETGRRFGLVSRAVQVDMEQLHLLTPGAVLHWEFRHFVVFERLARQGVDVVDPNFGRRRVPLEQFRKAFTGVALLFEPSETFETSAPRQGSRRYLHLLLQERPALLRVAVMSLLLQLFALALPSLTGAVVDRVVPSGDTPLLATLAAGMAALVGFQFLSSFVRAHLLLQLRTHLDARLTLGFLDHLVHLPFTFFQLRSAGDLMNRLNSNTTVREMLTSGALSTLLDGSMVVLYLGVLLAGSPRMGALVCGLALLQVLVFVFASRRQRELMAKNLEISASAQNYQVEMFSGIQTLKALGLEDKAVQHWSGLYVDVLNVSLERGRLEALTESITSTLRMASPLVVLATGALLVMEGQLTMGEMLALNALAVGFLLPISNLVTTAFQLQLVRSYLTRVDDVLQAPPEQPPGTRYRAHTLQGRIEVENVSFRYGANSPRVVQDVSVTIEPGQFVAIVGASGAGKSSLAHLLLGLYLPSSGSIRFDGVPLVEMDLKEVRRQMGVVLQNPSLFRGDIRRNIAYADPLLPLETVQAAAKRAQVHDDIAAMPMGYETVLSEMGSSLSGGQRQRMALARALVGNPAILLLDEATNALDAKTERAVQDAIAELRCTRVVIAHRLSTVRDADLILVMNAGQLVERGTHAELMERRGEYFELVSAQEGPRKAVG
>NC_017030.1|WP_014398023.1|6583971_6585375_-|MBL-fold-metallo-hydrolase
MRFAPDVVVDLTPLPDERVGALPFTELLWGLLRRGFEPDASRRLLEDANARLKRPLLRPGAVEDGGPLVDDGVLFPAPGPWWWVLQQGESRWSTRLEPEAVPFVADFLRAVARADTLDEVRAAWPFDAEDFEDALFLATPPEAPWPEPSGPGLYRREHASLLVCSRTTSVLVDPIPLQRRLRHIGSVPGNLAPEALGAVAITHGHVDHWHVPSLLAHLPRRDTPVFVPRVPRVNLLTPQDFSHVLEACGQAVQAPAWGESRRVGDLRVDVLPFHGEQPAPDGPPLPEGLRSWGSCYRFDTGDFSCLVLVDAGDDPAGRMAEVVARSRKAHGPVDVVLACQREFLAPFFGGLSHYWASLPWERLRGLYEDHQAGRLRSSTAGPKGVADLCALAGARYFLPYANGFEGVGRPITDVGWGDGEPSEAVCNAQVREQLARRGATTEVLDWKPGDVARFERGRLVLERGPER
>NC_017030.1|WP_148282353.1|6582857_6583958_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MDVDPGWRPRAPLASGPSESRAFFPASRARTTLPSPPRIACPGGRCAGRGRGLQSARTAHLQDRRVEKHVTRSGRAWAWVTTGVVLLGPGGALASSPEEAREPARVLAASRPLLGVVVASQVLDVVSEVEGRLSEVKARLGDRVEAGQVLATLDPEPLKLEWSARQANARAAGAEHARASLLLAQAKQKLQREQRIREHSAAEALEAAESAVALAEADLTLAQARLSEAQTRLAQAERDVAHARIRAPFTGIITEQYLTPDMRVSRATPLLRVVSDDLRLRFAVPETLAPSVRPGLPVRVRLAAVDVELVGTVERLAPEVDPASRHQKAEAVLTVPDALRARLSSGLLAEVFLQPPAETRTRGTHR
>NC_017030.1|WP_014398021.1|6581593_6582859_-|lanthionine-synthetase-C-family-protein
MSNAWKPVLSGPTRARALEAAEAIVQDLARAPLVSRPPDLAKGDAGLALFFESAGRALDTDLLDKVGQHLQLSAEGFLRAERTKVGLHGGLAGLGWVAARLSARHPDLDVEEVCGPVDEAIAQELELRPWPHPCDLRDGLAGLGLYALERPRTPSTPQLLERMVTLLEETAEPTAQGLRWPMPPNYLRLYGDPRAFPRGVYTLGVAHGMPGGLALLGALHAHGIARERVGALLEGGFAWMASVAGPGEHPGFPHYLHGDEPVVDARFSWCVGTPGITAVLWWAAWAWGHADWQARALAWAEAVAREGLDRPPFVPRRSANLCCGTAGTALLFTRLFHATGRPIFEEAAVRWYEHTLALRQPGQGPGGYCFQQDPKRPDENLQFGAAGIALALLAGATDQEPDWDECLLMSLRPRPPAKTEA
>NC_017030.1|WP_014398020.1|6580684_6581590_-|MsnO8-family-LLM-class-oxidoreductase
MRLGILDFCSLRQGATPRAALYESVELAQHAEALGFSRYWLAEHHEPSAAHHAPDMLAALIAGSTERMRVGVAGILLKLHSPMRVAKAFRLMETFFPGRIDLGVGGGGAAPSVMEAMRCDTRSLAEVNEEYPRRVAQLLELLRGESPFAFQPPGVPPVWLLGAARPFTARMAALHGTCYGHSLAHVSSRDDPSVLDIYRSEFRPRPEQPQPQAVLAVTGLCAPTETEARRRAAASGTKTGDVAPVIGDPRQCREQLEALAHRYGTQELVFLDQAPDAATRRECYELLSESIGLNASPAEDD
>NC_017030.1|WP_014398019.1|6580383_6580569_-|hypothetical-protein
MANTKSQKQDNAKSLKLKLSLKKETLRELNDSQVGALDQVVGGTIVWLSNNCCDYTQEQAN
>NC_017030.1|WP_014398018.1|6576994_6580228_-|lantibiotic-dehydratase
MSTNHSRPPSKAPTYAASGFFALRTPLLPFDTLVDWGQDLSAWRLPEGQRADALGEERARLRERLRGWVEEPVVREALFLASPGLEESIPVWLESPDSEWGQKVERGLVRYLSRMAGRATPFGLFAAHSVGSLGGKARLRVPERSAVRKHTRLDMDYVCALVEHVRREPEVMRALRYVPNTSLYRTPTELRYLEMRQRGRERSYGLVAVEPTPYLDATLERARAGATLEALAQALVELDAEIPLEDARLYTVDLVEAQLLVPTWAPNLTGPEPVPFLLAGAAGIPALAPVRERLSAVQSLLADLDAAPPGASPASYRHVARTLEALPVPVELPRLFQVDSVRPAADLSLPPRVASELLRAVEVLRRITPERSEQDPLVRFRERFAARYEGRSVPLLEALDEERGIGFVADPRPGGGTGPLVKGLGLRSPRGAEPAGLDTRARHLLRRLQEVSAARAHELVLTEEDLRAMEAETPRRLANAFGVVSTLIADSAEAVDRGDFRILFENIHVAGAMYMGRFCHGDPELEARVREHLRAEEALRPDAVFAEIVHLPQGRMGNVVCRPALRRHDLVFLGQSGVPEEDRIDVADLRLSLEGHRLVLRSERLGREVVPRLTNAHNYVGYGLSLYRFLCMLQSEGGERGMRFLWGPLDAASFLPRVRYGRTVLALACWNLPSALLQAWGKLQGAARFDAVQRYRQEARLPRWVCLREGDNQLPVDLDNVLSVETLVHTVKERPLAVLEELYPGPEGLCVEGGDGRYVHEVVVPFVREPSPVAPPLPELAPALSAQVARRFPPGSEWLYLKLYTGTATADRLLRGGLGDTVRQVLASGAVDRWFFIRYGDPDFHLRLRFQGDPARLESQVWPVLRSACADLLDEGTGWKLQLDTYEREVERYGGPVGVVLSEAFFSVDSDATLDLLRTCEGDAGADLRWRLVLKGLDLLLTDLGLPLDAKARVAERARDGFASEFKPGKVLETQLSARFRAERPKLEALLDATPATEGPWREGLTVLQQRTERLATVGREFQAAEREGRLTMPVEALATSLMHMHVNRVLPDDARAHELVLYDFLARLYRSRLARG
>NC_017030.1|WP_014398017.1|6573023_6576950_+|Dyp-type-peroxidase
MRTPSLLAAEHHSAKSLSTQQGNQLSHELWSLVQRGLVYPSPYAVFATFWRTPGGTGEPLTRALLQTLMRDVREEIHTHYGSANSSAIVGVGFRLWQEWCAEDGTDLPEGMKLAFPEESSPAWRSNVFSRSNGTFVDSQGDLWFHIKSDEESHCDAVFEFIRARLQDQARCVRSGPHDHQKAATKSTRPDKRGGKVLGCRFAENLNNPSDPVSIQEQTLVGFEDPAHLGASFVLAQRFEINWEHLLDMSPQQVEDLVGRTTEDILIPSQDQRSHIKSARVQDAQGNTLQVLRLGLPFGQANTVHNTELRAKGASLRDEAGIYFAGYARSVRALEAVMNQQIGDQRGFMRDRLLSEVRSNLGGFYYIPSQADLGLEPVKLQSAEQQDWKRFPGVDWSRLDRHFDVSSSNGYMHYNHKNYLFQMATMSGDKRRTHQPPSNRVLQLLSDAFSRWQDNWYVNRSQQELEHLCAYVARQYGPAKAREVMGLSVVERMGWAIKVSLGQVFASDAYGFRGRRQDAQGNWYNGADTYRIHPVELIVGALPNLGLGQGRYVIDYARKDEELGNFFAGLSSASGVGHLVPGFQRVLDRGLGGLMADVQARHDSTQDESKRQFYRGVVLSLEGVRDSCLAYAALAGKMASELPLGQHAERDNLLKIQERMQRLATERPQTMLEATQLLFTLHAGLHLIGEPTAVGRLDQMLFPFYERDVAAGVLDDEQAQEIIDCFWVKLGEKVLLNRQFVEDHQPFGNLAMGGMSGNYPQGAANNQWIQQVTVGGTIADETPGEGRPAYNRVTLFCLRAARRLPLNAPCLSLRVRKDIPPEYLHEAALAILSGGAHPILLSDEKIIPGLLHSGDGVGQGTQPTAATPVAQKAGSAWSSEVVLQAARDYACDGCYEPQIVGQNWFTLGGMTALSPLEAALNQGKSWSTAGPMYFRGQRVSFTSPPPSAIQSFEQLQDLFFQHLSWMYAKQADGMVGVFGTMSAVCPSPLLSVFVDDCIDKGLDLYGGGARYNMVAPCITALSTVINSLYAIRKMVFEQDTAVTSLPELVEALLCDWGHQMNEPFISTFAGPARIEAKAQRYRDLRQVALAQPRYGRGNEEVDRFGNAFIQRVAETVVRVFTEPAEPTAQKMVDLAKRFGTPEKPFGGFQVQPGAGTFENYVEFGATCGASADGRRLGETLASDLSPSPSIADQPLDHQEEGFVRALSGYTGAGAEGFTSGAPTDFNIREDFPVGSLERVLHAFAQGQGSNILTITCANPETFEHASKDPEKYDVLRVRMGGWSEFFVSMFPAHQEQHQRRPLSTPDVER
>NC_017030.1|WP_014398016.1|6572119_6572671_+|transposase
MVPTLTATLALKGERPVIGTRDCKDVVHTFASANVTTGEVTSRLYGSRTQKRRRDGLSKTKRMQVAFAHHLLDVARAYPANEYPEVVLIIDNAPWHRGRPVDWALGRYPHLTLYRLPPYSPQLQPIERLWRPLRQRATHNLLFDELTELQYALRSGLGYYRARPQVVLNLLGSFWLPTQSAEA
>NC_017030.1|WP_043321873.1|6590895_6591168_-|helix-turn-helix-transcriptional-regulator
MIAANVRATRLKRGMPLEGLAEAAIITTAYLQRVEYGRVNISVVTLVTLARALETRLDTLVESARLEGGDQAVPGAGQTERSTRGETAAP
>NC_017030.1|WP_014398027.1|6591318_6594072_-|DEAD/DEAH-box-helicase
MAGLERLHPHLQHAIIHDLGWRSLRPVQELTIDAILDGCNAVVLAPTAGGKTEASIFPVLSRILTEDLKPVCALYVCPIRALLNNQEERLSSYARMVGLEVFKWHGDVSDSKKKKFRETPAHILMTTPESLEVMMISERTDAKSLFSGLSAVIIDEVHAFAADDRGAHLASLLERLVAMTGRDIQRIGLSATVGNPHVIGEWLQGSSKRPFRLVDPPKAKAQRDLRLDLCVDISEAAKAIGQVARGKKSLVFVESRSKAEKVAHALAGTGVEVFIHHSSVSRADRTLAEEQFAKGQNTAIVCTSTMELGIDVGDLDQVIQVDAPASVASFLQRLGRTGRRANTRANCTFFCLSSESLLQSVALLRLAEAGWVEDVTPAAHAMHVLAHQVMALILQEGGISRHTLMPWVEAAYPFSSVRPERVQELVDTMLEREILYEADGLLSLGQRGEKLYGRKNFFELYAVFTAPPVMRVQHGKEDVGYIQALFVSMHDASAGPLCFRLSGRAWEVGQIDYGKGVLHVRPADYGRVPSWLGLPGVLSNALCQGMLDVLLHEKQEGAWLSKAAAAELAVVRDSYDGLLEEGTAPLEDHPDGVQWHTFAGGAVNRLLAAGLEQKSGKKWVAGNLSLRCKDIAFSAADDAIRSLADLNWERVAAGAAREMARGMLSKFQPCLPEEAEDRLLSERLLDQAGTLRFLANVRVNGSRVAARPTGMRLADVEVTGPLPLELTLRGLPGVAAAPKNDVQWVDTLAALRAVSEELRAAEVVGLDVETALDFGTLYLLQIATRTRTFLIDPLAVGDLQPIVDVLSGPTPLKVIHNARFERRVLAALGIALDGVFDTLAASRRARGTDALGGHSLAMVCERELGIVLDKSSQTSNWSRRPLEADQLSYAALDAEILLALYDRFKDAGVAPGAGGGN
>NC_017030.1|WP_014398028.1|6594074_6595445_-|BREX-system-ATP-binding-protein-BrxD
MAVVPESAAIVNALRSGLVPNVGLEHFATGLDALVGAVNEDLDFVAGGKGLSKWIRGEYGTGKTFAARYLCAKARERKFASSEVQISINDTPLHHLETVYRRLIEKLETAADGPNAFQAIVEGWLYQVGDEVTRLRGISEDDPGFADATEQRLEDKLADLSKRNPAFAQVLRAYHRATHEGDFATAQGLLAWLAGQPHTDRSVLAAAGVKGKVDGQASLTFLAGLLQLLRQSGYAGLVVVLDEVETVQRMNTQTREKSLNALRQLMDMLAKEELPGLYLVVTGTRDFFEGYKGLKALAPLYQRVQVNFSEDSRFDNLKAPQVRLTPFMDDRLLTVGARIRNLYPAKNPARLTERVSDAFLQGLVTQVTAGFGGKVALAPRMFLRELIDVMDRVDIHEAYDPREHYKLELDDGKLTAEELAAKHGRPVEEPPEEPEEPTSNDSEGPPPAPARKRLDG
>NC_017030.1|WP_014398029.1|6595444_6598027_-|BREX-2-system-phosphatase-PglZ
MSAAQLLLRRLLEQSGGASETGYLLVIDGEGLENLPDQMPTPKGSYGVHRISSELGLRHLLWKAKGAPLIAVMPEDVARRIQNAPDLLRRARNQRVHALSVNDVLEVVLGVRVVGADAPYMQQLALENVERLGFAMSHRTLPTVVDRRLLTELLVDVSVGEQVRTRSPAQLLAAWVQEPPRWSPNISQLVRDAMPSLHGDEGRLLAWALAEPEKRLRDLVVYGAVLTVEAAELPKPAWGPLWRAATEPPLEMDRRILRRTVARLAEETLALLGDAAGDLLAGADRVGRESLTPTQLQTSRVLPLAFSDRCHELAQQAASGKAISAADITWLSNHRAARMHRGDLAVLESMARISRYLNQPFSPKLDLLEQVRDYQRGGAFVDLAMMQLRRALASSVHYHAEANKLLAACRERRDRENRHFAETLSGGYEAALHREGLTPLHRLWKRTVAPVWQHEPDARLFLVVLDGCSYPVFLELLYALAQDSSFPLGIKPDASGLVAGLPALSPLPTITSHARGAIFLGELPNDPLISETVFRDQDEAKTDKARFNQNAALGSRNRRLFLKGDLTDGGQELLSALEDESLSVVGVVFNAVDDQIGSSNTGATVKISPEDITAFKPALRVALKAKRRVLITADHGHSLFVDKSLRSGNGKTPRYTALGKHEPVPEGFIEINIAGLGGPPERRAFAWRSGAYLGGSQVGFHGGCGLEEVVVPLAWLERDGLHADEPAWWYGRGALAEVTTEVKPVQPPIVTPLPSDEVPAKPKAQLSLFNPADKADSLPIPKELLAKLSLDEKSILVLLRETGSARASELAERLKKNPGRLNGLMRSLRRTLHEGGHVLFSDEVLPSGETMYRYQPKEGR
>NC_017030.1|WP_014398030.1|6598023_6601650_-|hypothetical-protein
MTTITEAFELPRPEDIRAMGFVVKLRELDPNSEEVEQLARDYVVTPAVEKELPRILDDMKQVFERGEEYGRFIHGSFGSGKSHFMTMLSLLVEGALPAWKKFRPLLNAHRDAKASKGGEASDHEAWLTKAGLLVVRIHMLSVRGKSTGFDRAVYEGFNAALKRRGKAPFEFLNVDAIFEEVRREAKEYGEVVWKRLETEGIVGGREDFEALAAGSIQAKERFARAWLKYKGRDASDAGIDPRWSEGLNRMAEHSKAQGFGGIVLMIDEFLLWLAEKSGQEFVAEINNLNVIVDHNTGQRPTPVFVFVARQRNLQEFFPDLVDESKIHEHLDHHAKRFEITKLQDVELRHIVRGRVLRPKKAGEVKAAVSSLSEKHSKVLPALLAGGDLDYVRDVYPFHPALIEMLVDVTSLMQRERSALRLLYELLVVHYPKLPLGEFLPVGSAFSAIFPESGVEASKKVELMQDIHHQYYSRLAPAMAKMAEEGGAEFNDERRRALDQLVKTVLLAEVSPRLKQGGLTIERLVQLNAVDVEGETFRGQVRVAETDLLALSQRVPDLQVAGQGKTALVRYVLGRVSLGEILGRARSKVDNPAQRFRVFWLALREALGVAGTKGFEDGGPNEGDWDLSWRRTKRRGRIKLGNVREMSYEDFAPPDGAFKILVDYPWDEPGHTVDEDRLRATNVRKKQGLLHTVCWLPRHMSPTELGVLTELAAVRYLLSEAGQEDLLETLGSQDKSKVLDQAGIRQKTLEGQLEDLLKEVYVRHGEFFALISDVDSSRPRETLAENLEHIAALLMDRRYPQHPAFLAEPKKQDLESLLGWMVDAGEGSVSVAYDENVGKVLKNLGQPLELVNLGQTKASLRLDSRYIKDVLHRTDQDSVSWSPIADHLRETYGFQPLLIDLFLCFLCQRDHRALEDISGEPADVRIGMSQTTRIRLQRGKLVSAADWHRLRDLGSQLFEVARPAAHRSLQGQDRFTTELRTRGQAKRTVLQALHTRLVHLGVQGGDRLKELSTANTRLGPLAQTTTDSHKVLSELLPAWPDDASDALRTLVQQAETLRDALAELNEHARGNLKAGVNHLVIGSEVSGHLRALDSRLEAAQAEQPLTKDWVATWNKKAQELIKRLIEQPQSPQPSVTGGGVQPPAIGGGAQSPLVGGGTAVTPRTVLLKKRVNPTDADAISDFLAEVRKALTEQGAKPISVVLVRTEEFE
>NC_017030.1|WP_014398031.1|6601666_6603670_-|DUF2326-domain-containing-protein
MTAGQMRIPGIDPPRQIRPSSERMAPAFWVYRIRILSELTKGDEHVVRDVKLRRGLNIVWAAHNSAGVDNALFRDGVAGHTAGKSTFCRLLRHVLGDGGFAPDGVKRRIRSKLPNAWVVAEVFVNDVRWVVARPLGIGHRSFCLRDRTIDDVTDTTAERRDYQEFVEALAKSTTEALASKKFPISDKLVGWEHVLPWLIRDQDCRFADFLEWRHRASGSDAPSLNVEERQFLIRTVLGLSSDAERHELQRNAQFVADKEDAARSAPLLRHQADTDRQRLSTVLGMELPLTSTPLFGSATRAELEKRRAELKTRKQELEESDRQEELRTLLEIASENEGALKEKLKGVQERLDAVQGMVGELVGTQQSGLLASLPPSRDFCSVPLRMAHEKCCPLAVGRPSDISSKRSERAATEELAIERGLAAAIQQEIARIKSEIEAAERATKNARRQLLAASTAYVEANANLREENAKLDHVGQLIDAAEKTANDAASKAESIKQLTRDIEESYSRQDKIREAQRVTVHRFSARFDYLVRALIGDQVTGRVETSGRSLSLTVEERGERDSTAIATVKLLAFDLAALVASIEGDGTFPRFLVHDGPREADMAPDVYERLFLLAHEIEKCFEGEPAFQYIVTTTTTPPEKFIERDAPWLCLQLSGLPAQERLLRQDL
>NC_017030.1|WP_014398032.1|6603666_6607665_-|BREX-2-system-adenine-specific-DNA-methyltransferase-PglX
MKANDRARLTTALRDHVAKIAADLRAKMRAPGAARVAAEQLHKDERVAEDFEVWTDLLSRRAAVLWVLKSVYVRVLEDRGLLAPGRLLDPEAQQLFEKLAPNLGETAFLRWIYKDLASTRGGMPELFSPQPAEVALPSDELSRALIGFWRHRDADTGAVWSFVEERFEGELMGDLYQELDPVVKDRFALCQTPDFVRAFILDRTLTPAIETFGADDVRLLDPACGSGHFLIDGLKRLVAATAEKHNDWSKENVVAHALDRVVGIDLNDYACALARTRLIMTAAELAGVTKLADAARFRPHVYWADGLEQVEKEEQKLSTQFDLFTKVEEKPRATLTRSDVRAALKKVFAKKFQAVVANPPYILERDEARKEYHRELIGKNRRYVSATGKYSLGAPFTERCFQLADKDGFVGIITSNNFTKRDFGKALIERVLANLDLTLVVDAAQAYIPFHSTPTVLLFGRHRKPVGDAVRAVLGKRGESGTPCDPAHGEVWTSIATNWPSVGFDNDYISVADVPRTMLNVHPWSLGGGGASELKQRIESAAESTLGRLSESIGITCFTLEDEAFIASEEVLVRHGIPADQRRPMVEGDLIRDWAVAPTDVAVFPYDDTLNVLASVDGSKLEAWLLPYKTRLSNNKMFGGRTKVEDGLKWYEYGRFTASKLRTPLSIVCACVATHNHFVLDRGGRNFKQSVLVIKLPSEATEGTHLALLGILNSSTACFWMKQVFYPKGSKTHDVDSAGTLPENNRFDFAATGMNAFPVPHGLAASSAGTIAATINALATERSDHLPHSVVRRPGVLVSSTALRAALREAEQREMSAFLRMVFWQEELDWEIYRLLGLTPQGSTNLLAECDVQPDSRPFAWAEGMLPSGLSPKVAEEYVRRRKLLESERFLGLLESPVSKRLWRGTQGVFGRYDRTYLDKTRTALSAWFAGRVEAVARDRSRHFSLEHLVAALQDDDDALAVCEVLTDRRDFNLSQLVAQVLQAESVPSHPLHTYKPAGLVKRQAWERTWLDQARVDAGEKTSPEVPPNYANTDFLKPEYWQLRGKLDVPKERFIAFTEVPGRSGVETLYGWAGWTAQQRVKAILAIDEELEDDSVPLADRIGLLDSAWRLLSDVAREDAPAATRLKAELQALVGIEGPSTTLIGDWKKRFPPPSTRAAGPRRTSTKEVEDDDSFDDLPAIIPDVSSPDDAALFIWAVLHASGGSATRTDLARAFALRARPNLLKRLAPAPLKRAVTHWGTTVGSRSVKAGLLASTLAALAERNGVVLGTNSEARVTVSTSPHTPSEEQIDPWFRFEADLAVKVLRAQPVDDFSSIDKSLSAADRKLLETAA
>NC_017030.1|WP_014398033.1|6607675_6611764_-|protein-kinase
MAAKFIQIGEPAHDAERQALRFLVEGLPESFTVYGNAWLVERSGVVYELDTVVVAPHAIFVVEIKSYRGRIEGTDNDWWLPEKIRSPLKLNRITSQVLKSHLKNASYQAGQVWTEGLVFLSATTDVGVRGPASNDRVHTRKTILAALQDPELIKRMSGGRALMPSSNAERELLELFTGAQSGPRPVRRVREYEVVETFEHHDTFTELLGKNTLSGAERVLRIYSVPPLATQTQRDRISERARWEAQVLGRLGRSEGVLTADPPFSDEAGIVLPLEHFKGITLTTWVERYGPDARGKEKAELRVRSDLWIRIAQTIDEVHRQGVVHRLLRPDVVLVEDKQEPTEVRVTGFDLAKQMTSDATISLTTIHDDRLVYAAPEVVTAFSSAEPASDQFSLGAMLALVLTGKPLFENTRQLMAQRRLMRRVRDISQRLPLSLDEAVAKMVELRATDRYATLAEAIEAVRIGRDPSPRVQALIQNVGRAQLDADNLQAGQRIGSDYEIVTRLGQGGMAVVYAARHLVSGRTRALKIARSEDAAEEALRGEYTVLTGLDHPNIVRVIDLTKMVEGRLTLVMERVSGMNLRQWFAQHPAPEPTTQRRLAEDLIAGLDYLEQKSVTHKDLKPDNLLVSDGRLTIIDFSLASMPEDAPYGGTALYRDSASARWTHATDRFAAALCLFELYAGRHAFEGRVPEPGQAPIVADDDIQPTGLAAFFRKALEPTPEKRFPSARAMREALLVALGEDTTTASSVPPPKQIDATTPLRTSGLSTRAINALARCQVHTVGQLLALPDAQVRAIHAIGTKTANDIIAFQETLRGRGLEGTESAGTLEPPLLPDLCSSPEPVQKLPLGETLRSALAAGGLPTVGAVASVTRSALLALPGIGRKRLAEVVEALYQFRAYTEGKATGGDDGAHTLDRVWELATRPLTPEQRIAVERVIGITGEPETQEQIADDLGTNQPKVSHDVSKGLERMDLSALADLTSAFDAVVDGFGGLVRLDEIGQRFESEWPAGVVTGEGIVRVIVRVTPGRAHIFEVDGAEQPIVARPIFDRDTVKAFAAEVVRLAGQWPPVEPDTARRTLAGLLPHFDGDPLALGVRICEDVEIAETGHLFIGPVDPKHSIGFVLDQAREPLQLEDLAVRVRRIFGPHTPYPDPDHLLAILRDLDCRVQGALVLPGRAGSIVAAQPLAADELPNSFGAERSPELVVRDMLKEAAGSRGFRMLVTPPEGHAEIGRSVSAALGGKWLSFDDAFFGEHSADIKSLERAERFVAQREALTEAAEQTLFNLLEEYGRPGNVIVLGDTALFGLCEALDLPRRLYDETLSGSRGFWILVVPGVIHNRQPRFNEGSAMWHLEGATLPLLHPLPG
>NC_017030.1|WP_014398034.1|6611767_6612517_-|hypothetical-protein
MPSLDVSTLSDAQRPTGVWVASLLHALARDESAGRRRPRLTEPKLDTWSRFRGRLSSVDLVSLLFEDAAVLHRVPFDPEVVGGALRPERLPETITDDWLKAIDSLSLNTAGADYILEQARLLGLPTRMARSDLHVMKPHQKVLELPGTGGQLAHHLVSSQKDLTLQDNFFVACGSWQELTLAGIVALELGAPHSDFATSADAADLKNPEHPLRQRSFDFVVGLHPDKGGLFRVEDQLAIWFPTAKVLWV
>NC_017030.1|WP_014398035.1|6613101_6613515_-|preprotein-translocase-subunit-SecG
MLTFFTIVHVLLCVFMIFVILLQPGKDAGMGSALGGGAATSAFGGRGAVTFLSKLTGVCAGLFFLTSLGLSFVGLRGSVAAGGSVATPPAKTAPATPGATTPPPATPGAVEQERSATPPAEGQQAPAPTTPAPAPAQ

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Crispr_ID: NC_017030_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_24

6812133-6812231

Orphan

Consensus_repeat	Method
GCTCGGCTGGGGTGGAGGCCCCGGCCTCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_24

>merge|NC_017030|24|6812133-6812231|CRISPRCasFinder
GCTCGGCTGGGGTGGAGGCCCCGGCCTCGGGGCTCCAAAACGTGTCCGACTGTCGGACAGGTTTCCGCGGCTCGGCTGGGGTGGAGGCCCCGGCCTCGG

>NC_017030|24|19|6812133-6812231|CRISPRCasFinder
GCTCGGCTGGGGTGGAGGCCCCGGCCTCGG	GGCTCCAAAACGTGTCCGACTGTCGGACAGGTTTCCGCG
GCTCGGCTGGGGTGGAGGCCCCGGCCTCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014398200.1\|6802337_6802856_-\|DUF507-family-protein	unknown	unknown	gnl\|CDD\|367914
NC_017030.1\|WP_014398215.1\|6821747_6825416_-\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|224000
NC_017030.1\|WP_014398209.1\|6815953_6817159_-\|carbohydrate-binding-family-9-like-protein	unknown	unknown	gnl\|CDD\|187678
NC_017030.1\|WP_014398212.1\|6818957_6819398_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398205.1\|6810515_6812006_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|366133
NC_017030.1\|WP_052313081.1\|6799638_6799944_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398210.1\|6817345_6817981_+\|outer-membrane-beta-barrel-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398204.1\|6808917_6810387_-\|cysteine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234705
NC_017030.1\|WP_014398199.1\|6800863_6802276_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NC_017030.1\|WP_014398208.1\|6815683_6815944_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_043321913.1\|6813224_6815684_+\|DNA-internalization-related-competence-protein-ComEC/Rec2	unknown	unknown	gnl\|CDD\|225212
NC_017030.1\|WP_014398206.1\|6812538_6813033_-\|CarD-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224248
NC_017030.1\|WP_052313080.1\|6799398_6799626_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_043321912.1\|6804947_6807116_-\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_017030.1\|WP_014398198.1\|6800298_6800649_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398203.1\|6807195_6808872_-\|M28-family-peptidase	unknown	unknown	gnl\|CDD\|349910
NC_017030.1\|WP_014398211.1\|6818109_6818946_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NC_017030.1\|WP_014398214.1\|6820424_6821735_-\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NC_017030.1\|WP_014398201.1\|6802994_6804935_-\|excinuclease-ABC-subunit-UvrC	unknown	unknown	gnl\|CDD\|234792
NC_017030.1\|WP_014398213.1\|6819462_6820368_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014398200.1\|6802337_6802856_-\|DUF507-family-protein	gnl\|CDD\|367914	pfam04368, DUF507, Protein of unknown function (DUF507). Bacterial protein of unknown function.	8.58501e-44
NC_017030.1\|WP_014398209.1\|6815953_6817159_-\|carbohydrate-binding-family-9-like-protein	gnl\|CDD\|187678	cd09620, CBM9_like_3, DOMON-like type 9 carbohydrate binding module. Family 9 carbohydrate-binding modules (CBM9) play a role in the microbial degradation of cellulose and hemicellulose (materials found in plants). The domain has previously been called cellulose-binding domain. The polysaccharide binding sites of CBMs with available 3D structure have been found to be either flat surfaces with interactions formed by predominantly aromatic residues (tryptophan and tyrosine), or extended shallow grooves. CBM9 domains found in this uncharacterized heterogeneous subfamily may co-occur with various other domains.	2.53789e-64
NC_017030.1\|WP_014398205.1\|6810515_6812006_+\|FHA-domain-containing-protein	gnl\|CDD\|366133	pfam00498, FHA, FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.	1.1513e-23
NC_017030.1\|WP_014398214.1\|6820424_6821735_-\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NC_017030.1\|WP_014398204.1\|6808917_6810387_-\|cysteine--tRNA-ligase	gnl\|CDD\|234705	PRK00260, cysS, cysteinyl-tRNA synthetase; Validated.	0
NC_017030.1\|WP_014398199.1\|6800863_6802276_-\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	4.12697e-06
NC_017030.1\|WP_043321913.1\|6813224_6815684_+\|DNA-internalization-related-competence-protein-ComEC/Rec2	gnl\|CDD\|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	5.91875e-64
NC_017030.1\|WP_014398206.1\|6812538_6813033_-\|CarD-family-transcriptional-regulator	gnl\|CDD\|224248	COG1329, COG1329, Transcriptional regulators, similar to M. xanthus CarD [Transcription].	2.43011e-50
NC_017030.1\|WP_043321912.1\|6804947_6807116_-\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_017030.1\|WP_014398203.1\|6807195_6808872_-\|M28-family-peptidase	gnl\|CDD\|349910	cd05660, M28_like_PA, M28 Zn-peptidase containing a protease-associated (PA) domain insert. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins containing a protease-associated (PA) domain insert which may participate in substrate binding and/or promote conformational changes, influencing the stability and accessibility of the site to substrate.	2.24891e-87
NC_017030.1\|WP_014398211.1\|6818109_6818946_+\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	1.64823e-16
NC_017030.1\|WP_014398215.1\|6821747_6825416_-\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	9.69502e-93
NC_017030.1\|WP_014398201.1\|6802994_6804935_-\|excinuclease-ABC-subunit-UvrC	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
NC_017030.1\|WP_014398213.1\|6819462_6820368_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	5.5441e-11

>NC_017030.1|WP_014398205.1|6810515_6812006_+|FHA-domain-containing-protein
MAPPNPKRPPRPPRPPGQQASSDDPSEELPFDDDEVAPLQADDPRPQRVPQYPAGPRKAKRRGPGERSRSDRELSPRYDWAMEYSDPGLTPAFVYVERGPGAGQLVPLRQGSITLGRSSTSDLRLQHASISRRHAQLTRRGNVFTVRDLGSQNGTFVNRLRIKGEVELQPGDELSLGNATLRLRGSGSGPTMSRTALDPLRPRTAKRRLNGVAVAVAAAVVGSAAAALISMVAMRMGDWTPARARAEGAPAKAPGTPATPAKEAQETEAAAPAKEAPSKGSSDGSPGAAKVLSASDIARRAQSSQLTPSTGATTKDAAPSALEVAKGTGTAKAGEPHPGASVVAASGRKASPSTEPSGLPDEGQRADILARYESGDVTGALAQAKRANLAPLVQQLTRFQTAEAAARAALAQQDRPRALDALIAAVRADGELSQGWSRQGISLRRQLAGMYVRTGQEAVRAQRFADARAAFTTALQYDADNAEARSQLAALPTQAP
>NC_017030.1|WP_014398204.1|6808917_6810387_-|cysteine--tRNA-ligase
MAPPSIRLFNTMSMQKEPLEPLVPGEVKVYVCGPTVYSYIHIGNARTFTSFDVVVRYLRYRGFKVTYVRNYTDVDDKIIKAAHETGEAPVDLASRFVEAFREDARALHLREPDVSPRVSETIPEIVAIIQTLVDKGYAYEAKGDVYFAVDKDEDYAKLSKRNLDDLCQGERVQPGDLKRQPLDFALWKAAKPGEPSWDSPWGKGRPGWHIECSAMSEKFLGRTFDIHGGALDLIFPHHENEIAQSESATGQTMAKYWMHCGFLDLEGAKMSKSLGNVVRLRDALAKVDAEALRFFFLSTHYRHPLNFGEKALQDAEGRMEYFYETLRKVDERVAGKDFGKGPLHGEPARFLTEFESAMDDDFNTAGALGALSGLFGFMNELTDKPPVKDKPLVGRTLQALREQVRETSRVLGLFEDDPGAWLLRRRDRAVRERGIDVAEVERLLAERTAARAAKDFAKADQVRGALKTLGVDIMDTPAGTSWKVAAPAS
>NC_017030.1|WP_014398203.1|6807195_6808872_-|M28-family-peptidase
MRLLPALFVSLCSASVLAAGAPSVTPQEKTAEQAITADLLRAHVRFLASDLLEGRGPGTRGDALAQEYIATQLEGLGLKPGAEDGSYFQRFDLMGIHSRPGTMTFQAKAGRVELQPREDFIAVSGVQAPEAKLDASELVFVGYGIVALEYQWDDFKGADLKGKTLVILNNDPEDDPRLFGGKARLWYGRWDYKYEQAAKTGAAGAIIIHTTPSAGYPWQVVRTSWTGEQFELPAGDAPRLQVKAWTTEDATKQVMKLAGQDLDALRAAAQKRDFRPVPLGVKVSLGLTNEVRRRPTANVLGLLPGSDPTLAKEVVLYSAHHDHLGKKDDGKPGEDVIYNGALDNAAGVASMLSVARAFTALPTPPRRSILFAAVAAEEYGLLGSAYLAAHPPMPPGRIAANINVDGGNVLGRTRDITVIGLGKSSLDTFVTAMAKTQGRTVKADQLSDRGFFYRSDQFNFARQGIPAAYFGSGMDFIGRPEGWGKEQRGQWEAKHYHQPSDEVRPEWDLSGAVEDTRLFFLVGAQVAKAPAMPVWNKGDEFEAARLKSLEALKAPPAK
>NC_017030.1|WP_043321912.1|6804947_6807116_-|excinuclease-ABC-subunit-UvrB
MPDFELVSEHKPQGDQPRAIGELTEGLLRGDRYQTLLGVTGSGKTFTMANLIANVKRPSLVIAHNKTLAAQLYGEFKALFPNNAVEYFVSYYDYYQPEAYVPSTDTFIEKDSSINDNIERMRHSATHSLRTRNDVIIVASVSCIYGLGAARSYVDLAIRAAVGEEMGRDGFMRKLVEAQYERNDLDFHRGTFRARGDTVEVFPAYEEERAVRVSFFGDEVERITEFDPLRGQTLGQLEKIVIFPASHYVAGADARQNAMRTIREELAEQLQKFKAEGKLLEAQRLEQRTMFDLEMIEQVGYCNGIENYSRHFTGRAPGEAAPCLIDYFPRDLLVLIDESHQTVSQIGAMYRGDRARKETLVNFGFRMPSALDNRPLKFVEFEEMVPQAVFVSATPAEYELQKSKGVVVEQIIRPTGLTDPEVETRPAGNQVDDLLEEVRVRVSRNERVLVTTLTKRMAEDLTEYYSDVGVKVRYLHSDIDAIQRMAIIRDLRRGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSHVSLIQTIGRAARNVNGRVIMYSDQMTDSMKRAMEETARRRDIQRAYNKEHGITPRSVKSNITDFTENIPDYDAGAGALPMAAEGENDLLEPKEIQRLIKEFTADMLKAADEMQFEKAAEFRDRVQLLKDMDLGLKPASRSLLRAPAKAADQPGTTPKKGRGRGRPSASGGGSSGGSSGAAKPAARSRSRKN
>NC_017030.1|WP_014398201.1|6802994_6804935_-|excinuclease-ABC-subunit-UvrC
MDIRLQEKLDALPTEPGVYLMKDKRGTIIYVGKAINLRSRVRSYFNRSGDTRVFVSLLDTMLGDLETVLVHNEKEALLLENELIKKHKPRFNVLLKDDKQFISLRLDRTQPFPRLEVVRKYEKDGARYFGPYSSAGAIRETLRLINRFFRLRTCTDHVLANRKRPCLLYQIGRCPAPCVHPVPPDEYRKSVDEVAMFLEGKAGQLIEGLRARMKRASMELKFEEAARVRDQLLAIERSLERQKVATTDFKDQDVFALFREGDRILFYVLHVRQGRLNGGQAFPFGSQEFPDDELLASFVNLYYDQGGFVPEEVLLPLEPGDGTDGLEALLTERKGERVRVFVPKRGEKHELVNMAVKNAEQAFVERKRTKDETDTVLSRLQSKLGLRNFPRRMECYDISHFQSSSIVASQVAVTDGETDKSRYRKYKIKTVEKQDDFASMYEVITRRLKRGLEDNDLPDLLVIDGGKGQLASAHAAMKDLGVEGVDVVGLAKSRDQEVFDRDAESAKSPERVFVLGRKDPIVLPQNSAEMFMLTRMRDEAHRFAITFQGKSMRKSSLRSALEDIPGVGEGRRKMLLRHFGSLKRVGEASIEELTEVVGPAMAERVHAGLHGDPEDDTEDPVREASLDDASEPVHEKADGGSPPGAA
>NC_017030.1|WP_014398200.1|6802337_6802856_-|DUF507-family-protein
MRLYPKVIPIISREAIQQLMQDGDIEVEPMRVADAEMDLSAIMREYLANEERVNQATREALERRGYDYSKFNQVKREMADVRGFKMGDEGIEYVINQMIEFLLISRNVEEVYSPDNVLRQKMFQGMKKHLDVDDEIDREARSRLKHLQEGTSAFDIEYNKTVEQIRRARGLI
>NC_017030.1|WP_014398199.1|6800863_6802276_-|hypothetical-protein
MAGPITSILLSGVLAAAPGGDGVTFEGREASARTEQPDGYFFQGTLPFGDLTERGTGRASLSVQDRIGVANATFGDKAQLSASLRVGGTEYRVELTQAGFPPVQAMSRAPAGPLPPPPPHLIEGGVLMGTPIYGETGIGWRATTRAHAAMAVWGIGSVWRNGTLLTDSALVHAAALDAGTYSDDDTTRLLREARPGDTELVVVVWNLPPQAEPRGFIQFLYDNVSIEVEGARVPSLAVVPTTGELPSALGTLTPVLPTAFPAAVAPMSPPHFAQGTGGSGTAGTTGVATTTGTTPTAVTPGSGTVGTANLPSATAVPAEGPTTFSGTFAPSAPTNPPPVVSGVSPGSPALVGQGTFATPPTVASVSVGGFTAPQISAPDFNNFLGTTQVSPGIPATVPPLAQSSGTPTPPLVGTPAPLNTGAPTPLVGTPAPLNASPGIALPATPAPANAAPAAPAAAPAPAGGVAGPAR
>NC_017030.1|WP_014398198.1|6800298_6800649_-|hypothetical-protein
MPPPVAALATPAMLRRSDPVRGAVERLARTLPAREDAAVLLDFVEDDLREGLDALGDVQAHFYDLLLALHRETLTPVALMNAGENLHVLQRLEDLHEVVTQLRRRLSQAAGMIRHG
>NC_017030.1|WP_052313081.1|6799638_6799944_+|hypothetical-protein
MVMLGHLGNAGAVSARNARLSNLLDVLRTPVADNALSAWGELGYDIAPWLGLDGNHRLEPYVRIDYMDSQFKPRPELFDNLASSAPSTRWAPATRSRGSQC
>NC_017030.1|WP_052313080.1|6799398_6799626_+|hypothetical-protein
MLASDLAAVVRADVRRFEGFHFGVSAYYGGTTRNRPKPDRVKTCDDANPNVVAPCGYVSAPLFIADAHLSVNRDR
>NC_017030.1|WP_014398206.1|6812538_6813033_-|CarD-family-transcriptional-regulator
MQTSFKTGDKAVYPGQGVGEVMGIEHTEVAGQRQSFYVLRILENGMRIMIPINKVGSVGLREIISEEDVKQVYSILREKDISVDSTTWNRRYREYMEKIKTGSVFEIAEVLRDLYLLKGDKDLSFGERKMLDTARSLLIKELSLAKDCSEEEVESDLKKIFNLA
>NC_017030.1|WP_043321913.1|6813224_6815684_+|DNA-internalization-related-competence-protein-ComEC/Rec2
MVRYSWRDLGTRPLFFPALSLLLGALWATGTESFGGVFLLCALCLGGLGMALGPLPGAHLAVLGALALMGAGLSSLEARVDIPPSLKEGGSAVLEGELERVERFDGAVRLRLAVARAGSRQEPPTAARFHVSLSGRGERLDLHPGQRLRVEARLVPDAPPSNPGERDFSSARRRQGVAFTGGFAPGRVLALSPAPSWRLALEDVRGRLTTAVHGVAPSADAAALFLTLAAGQRADLDDSWEDAFSRAGLAHVLSVSGLHVAALALMTLALLRRGLVRLGGRSRTLEARRWAAPAAVPFVWAYVVFTGNQAPAVRSAVMASAVLLGLSLWRRADGLNGLSLAALVLVVWTPSSVVDLSLRLSFLAVLGLVLLSPALREALPLDRPAPSEPRVLKRWAAQARETVAQTLCASGAATLVGLPVVAAAFGRVSLAGLVSNIVALPLCGLLTGLAAGGAALFVVAPVVATPVLWAGAWASELLLVLTRGFAAVPFAAVEVPGLGPWLGGAYAVGLGAWALGSGRWRWLGMLVPGAVLGALLLPVLAPEPALRITFLSVGQGDAVVLRSQGHHALVDAGGVPEGADTGERFVLPFLKAEGVSRLDLAVLSHPHPDHALGLVSTLAQVPTERLWLSAGSADGPLSRKIISAAKGATVEEVEVGHPAFVLGEATLEVLGPPVDRELLEGANDRSVVLRVRHGDVTVLLAGDVEADGEAALEESLGPVTVLKVPHHGSRTSSTAPLLERTRPRHAVFCVGRRNRYGFPHPEVEARYRALGTECWRTDRDGAITLESDGEDVRLVSFLPRVDSAPPPVAGSGGQAQLER
>NC_017030.1|WP_014398208.1|6815683_6815944_+|hypothetical-protein
MISDDLDLRQLTTQLKARLGPGEPVGYLRGKSLMRDLLLDMRENRFSELEAEELVDTLEARGFVRFLGDPAERSVADAPWDISPHA
>NC_017030.1|WP_014398209.1|6815953_6817159_-|carbohydrate-binding-family-9-like-protein
MRLRSLALVPLLSSVLFVGGACRDEQAGPAHRTPKLPAPTTLRTLDAAPEGLTFRSGATFAGGAIVYLGARVTPEQATPGQPVRISHYFQAVRPPPQGFHFFAHVVDPESGQMLANADHEFQDGAAPLETWPVGRVLEDVHTVAMPATPARLVLGFWNDDGRLTVDDPRMQLGGNRMRGPLLGGEPPALPEYAVTRVKKAPVVDGALDDEAWKGAKPVTLAGSFDGRPVRLRTQARLVYDDANLYVAFDVEDPDIWGTMRNRDDSIYEQEVVEVFLDANADGRTYNELQVSPHNVIFDAYFPARRQGMDRSWDSGMKTAVKVRGTLDDASDRDEGWTVEMAIPFNRLAEVPHIPPQPGERWRFNLYRLEHHDRRQVEGQAFSPLFIGDFHALPRFGWLVFQ
>NC_017030.1|WP_014398210.1|6817345_6817981_+|outer-membrane-beta-barrel-protein
MSKGLLAGAAVVTVLAAGSAQAASTELRRSADMRGLTFLVGGGVEGYTSGLRDQIDPGLAYGVTVAIKPTNVLGLELGYTGAISNFNDSRVLATDTSGPDIVRNGAQAAVTLGLTATPLQPYVMGGLGLSRYNVRSAALGFQDDTVGNVPVGAGLRLHIGSFTADARVNYNFLFDQEFALTVPPSDVDLGGDETFSSGGRYVGTINLGATF
>NC_017030.1|WP_014398211.1|6818109_6818946_+|FHA-domain-containing-protein
MRFEFEHLGTPTPFELTEGHHLLGGGPDDHVHLEGLPPGLLTLRIDSGRLMVEAVRSFTVNAVRVLPGVSRLVVPGEVLGLPDGMCLRVLAEPSAPGRGVGTVAVLKGLLTDADLPPSRAATLTCLTGLDVGRCHALAEACTDIGRGDGAALRLRDRAVSRMHARIRREDPGFLLEDLGTPNGVFLNGVRLEAPAPLMDGDVVELGRSLLRFQAAFDEASGEARPVPRPMATVEEPAEAATPRPPEGGPRRLEGWIIAGAVALALGALLVTSLVAATG
>NC_017030.1|WP_014398212.1|6818957_6819398_-|hypothetical-protein
MDGRDRTVEGKQPHQVFRPRRVLAAVMAAAGLLWLGIFAWLFHFDGVPLQTFLSAAFFVVFFGVAVTYYGRTRIEVDSRGITCRGMVRTRRFSFADIRKLDVLPGPVTVYAIRGSKGFVHFTSFFRHHRHLARLLVERAGLSPLPA
>NC_017030.1|WP_014398213.1|6819462_6820368_-|tetratricopeptide-repeat-protein
MVRTRRFQLGVSAVVWLGTLAVPAWAQGTSAQPPAPEAKSAAQAARAPGPATDTPPGPGESQPQRTSQAVLAATRIRDGDALMRERRYREAAFAFLDAEHAAPDHVEARFKLGNALAVLGYYARAIEEWEAASRLTQDAAIRQSAQDNITRARVKQGELGASPQAVGQLPGSGPVADTTRAQARRAYEQGVQHISQRAYGPALQTLTQALQQEPLLTVAYIARGSANIGLRRYAEAAADYQFALKLEPGAASPLYGLAEAYRALGRNLEARDLYARYARSTAADVRPELKEESRQKAERLR
>NC_017030.1|WP_014398214.1|6820424_6821735_-|adenylosuccinate-synthase
MPNVVVIGAQWGDEGKGKVVDLLTEHAQVVVRFQGGNNAGHTLVVGGQKTVLHLIPSGILHPGKTCVIGNGVVVDPAVLVREIDALKPRGFLKDDAQLLISDNAHVIFPWHKLLDSFREKARGGSAIGTTGRGIGPAYEDKVARRGIRVRDLLHPERLRRRIDERLPGALEELKDLCAQAGVDVPTLETPQILAEFSALGDRLRPYVHDVSLFLSEQVRRGARILFEGAQGTLLDVDHGTYPFVTSSNCVAGNAAVGSGLGPTTIDKVMGISKAYTTRVGGGPFPTELSDELGDRLRKVGDEFGATTGRPRRCGWLDGVVLRYAVRVNGLWGLALTKLDVLSGIKTLSICNAYELDGQRVTELPGDYEDLERVKPIYETLPGWDEKIAGVRTFDELPEAAKRYVRRVEEVSGVPVVCVSVGADRGETVLLQNPFRS
>NC_017030.1|WP_014398215.1|6821747_6825416_-|UvrD-helicase-domain-containing-protein
MSDTAPHMLALEKNLALMAGAGAGKTYSLVTMTLHLFAGARQAEPLRPSRLCMLTFTDKAAAEMRKRVRERLDALAQGDVPLDAEKDLRASLARLERPFPTQDAWRKVREELGAATVGTFHSLCGQLLRRAPPAVGIDPAFEVLDELEAAGLLEDVTERVVLDALEGGDARVRELCAELGFSGSGFSDGLVAALMDVYGTLREEGLNAATARVGDGVADKAQLEALIEDCRRLCLDARAQDTKGEWSNLLSACEPALKGMTPDTFMQPGYFPTLRNVLLSEPRNLANLRKGAGACLKELLWKVKGKSDGSVRRLEDAYAAWRTAPFEATFRDLLTQVEDRHDAELTRRNVFDFTSLLVKARDLLRDHPEFRQQVQERLGALLVDEFQDTNRLQLELVLLLSEKREGGPRELAPDADLVASLPLEPAFLCAVGDRKQSIYEFRGADVSVFKVLADKIEAEGGMRGFLQNNYRSLPGVLSFFNRAFAGLLVAKEETPRPFEVVYEPETDDLSPTRPDLAEGPVVERLTLPEADTAPELREYEADAVARRLRVMLAPGAPPTVMAEDKKGLRPARGGDVAILFRTFTHLEEYRQALIRHGVPHRVLRGRGFYGAQEVRDLASLLALLADADDALAFAAVLRSPLVGLSDASLFRLAGDLPLSLGSPRLVDEEVRAAMSAREQSRLSRFLELIPVLRRERDRLGVHALLQAALDATGYREALAGSPYAEQASANVEKLLSLAARRDERGTGGCVAFARELRQLADSDPNEAQADLLDEGDPRAVQLLTIHRAKGLEWPVVIVPGMGGRRRSTSARAYFERSFGLALRPWMPDSLDTFTSERFEAVRAELKAREDAEYLRLLYVALTRAKDLLVLSGGEEKRAGTDTWWHRVDRRLDVDPDLRALANDVDVEQLPPPADPEPPTEEQLEQARIRLESALERMSDEASGAGAAVFTDAPVVASVRAVQDFLTCPRRYHQLHRLGLAIGSEPWEAPVRAAPLFVEPDGWLPVERPDQLVTRLLREVDLSLAGPDAEASERRAHLENLLRSAGRDPDEDELGDVLATVERFLDTTFARQLAVAPASTIHRGLDFVLDLDDAASVEGAVDLLWESPDGEAVAVLLRPGARHPRGPAACVHELTALALASARMVRDGVPVRVGVAFLGDASPEPEFLPAGSADAGAVRRLAEGVRALVQAEMSRAWPGWDKAACQALHCGFAEHCHPAPPAC

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Crispr_ID: NC_017030_25

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_25

6829412-6829493

Orphan

Consensus_repeat	Method
CGCTGCGAAACCGGTCGGACAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_25

>merge|NC_017030|25|6829412-6829493|CRISPRCasFinder
CGCTGCGAAACCGGTCGGACAGCCAACAGGTTCCGGGACACCGCCGCCGGTACCACGGCGCTGCGAAACCGGTCGGACAGCC

>NC_017030|25|20|6829412-6829493|CRISPRCasFinder
CGCTGCGAAACCGGTCGGACAGCC	AACAGGTTCCGGGACACCGCCGCCGGTACCACGG
CGCTGCGAAACCGGTCGGACAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_043321913.1\|6813224_6815684_+\|DNA-internalization-related-competence-protein-ComEC/Rec2	unknown	unknown	gnl\|CDD\|225212
NC_017030.1\|WP_014398218.1\|6830923_6831832_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176165
NC_017030.1\|WP_014398227.1\|6846596_6849470_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_017030.1\|WP_014398211.1\|6818109_6818946_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NC_017030.1\|WP_014398226.1\|6843234_6846177_-\|choice-of-anchor-D-domain-containing-protein	unknown	unknown	gnl\|CDD\|380152
NC_017030.1\|WP_043321916.1\|6841073_6842237_+\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|223715
NC_017030.1\|WP_014398214.1\|6820424_6821735_-\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NC_017030.1\|WP_014398210.1\|6817345_6817981_+\|outer-membrane-beta-barrel-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398222.1\|6839635_6840463_+\|chemotaxis-protein-CheR	unknown	unknown	gnl\|CDD\|224271
NC_017030.1\|WP_148282357.1\|6831889_6832783_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239488
NC_017030.1\|WP_014398216.1\|6825412_6828658_-\|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl\|CDD\|378929
NC_017030.1\|WP_014398221.1\|6836180_6839627_+\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NC_017030.1\|WP_014398213.1\|6819462_6820368_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_017030.1\|WP_014398212.1\|6818957_6819398_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398223.1\|6840478_6841090_+\|chemotaxis-protein-CheB	unknown	unknown	gnl\|CDD\|319752
NC_017030.1\|WP_014398209.1\|6815953_6817159_-\|carbohydrate-binding-family-9-like-protein	unknown	unknown	gnl\|CDD\|187678
NC_017030.1\|WP_014398215.1\|6821747_6825416_-\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|224000
NC_017030.1\|WP_014398225.1\|6842226_6843150_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277322
NC_017030.1\|WP_014398208.1\|6815683_6815944_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398217.1\|6829651_6830527_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_043321913.1\|6813224_6815684_+\|DNA-internalization-related-competence-protein-ComEC/Rec2	gnl\|CDD\|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	5.91875e-64
NC_017030.1\|WP_014398218.1\|6830923_6831832_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176165	cd08476, PBP2_CrgA_like_7, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 7. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.82452e-70
NC_017030.1\|WP_014398227.1\|6846596_6849470_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_017030.1\|WP_014398211.1\|6818109_6818946_+\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	1.64823e-16
NC_017030.1\|WP_014398226.1\|6843234_6846177_-\|choice-of-anchor-D-domain-containing-protein	gnl\|CDD\|380152	NF012200, choice_anch_D, choice-of-anchor D domain-containing protein. This HMM describes a repeat domain just over 100 amino acids long and usually found in tandem copies. Members appear to be extracellular proteins that have some C-terminal anchoring domain, such as type IX secrection (T9SS) or PEP-CTERM.	3.54879e-08
NC_017030.1\|WP_043321916.1\|6841073_6842237_+\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.62648e-38
NC_017030.1\|WP_014398221.1\|6836180_6839627_+\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	1.69824e-72
NC_017030.1\|WP_014398222.1\|6839635_6840463_+\|chemotaxis-protein-CheR	gnl\|CDD\|224271	COG1352, CheR, Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms].	2.57943e-53
NC_017030.1\|WP_148282357.1\|6831889_6832783_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239488	cd03394, PAP2_like_5, PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.07795e-17
NC_017030.1\|WP_014398216.1\|6825412_6828658_-\|PD-(D/E)XK-nuclease-family-protein	gnl\|CDD\|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	1.2827e-26
NC_017030.1\|WP_014398213.1\|6819462_6820368_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	5.5441e-11
NC_017030.1\|WP_014398223.1\|6840478_6841090_+\|chemotaxis-protein-CheB	gnl\|CDD\|319752	cd16433, CheB, Chemotaxis response regulator protein-glutamate methylesterase, CheB. This family contains the methylesterase CheB (EC 3.1.1.61; also known as CheB methylesterase, chemotaxis-specific methylesterase, methyl-accepting chemotaxis protein methyl-esterase, or protein methyl-esterase) domain, a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors. Signaling output of the chemotaxis receptors is modulated by CheB and methyltransferase CheR by controlling the level of receptor methylation. cheR and cheB have a strong preference to occur in the same operon, and a subgroup contains multidomain proteins with CheB-CheR fusions. Reversible methylation of transmembrane chemoreceptors plays an important role in ligand-dependent signaling and cellular adaptation in bacterial chemotaxis. Phosphorylated CheB catalyzes deamidation of specific glutamine residues in the cytoplasmic region of the chemoreceptors and demethylation of specific methyl glutamate residues introduced into the chemoreceptors by CheR.	1.24116e-88
NC_017030.1\|WP_014398209.1\|6815953_6817159_-\|carbohydrate-binding-family-9-like-protein	gnl\|CDD\|187678	cd09620, CBM9_like_3, DOMON-like type 9 carbohydrate binding module. Family 9 carbohydrate-binding modules (CBM9) play a role in the microbial degradation of cellulose and hemicellulose (materials found in plants). The domain has previously been called cellulose-binding domain. The polysaccharide binding sites of CBMs with available 3D structure have been found to be either flat surfaces with interactions formed by predominantly aromatic residues (tryptophan and tyrosine), or extended shallow grooves. CBM9 domains found in this uncharacterized heterogeneous subfamily may co-occur with various other domains.	2.53789e-64
NC_017030.1\|WP_014398215.1\|6821747_6825416_-\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	9.69502e-93
NC_017030.1\|WP_014398225.1\|6842226_6843150_-\|metallophosphoesterase	gnl\|CDD\|277322	cd00844, MPP_Dbr1_N, Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain. Dbr1 is an RNA lariat debranching enzyme that hydrolyzes 2'-5' phosphodiester bonds at the branch points of excised intron lariats. This alignment model represents the N-terminal metallophosphatase domain of Dbr1. This domain belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.22426e-29
NC_017030.1\|WP_014398214.1\|6820424_6821735_-\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NC_017030.1\|WP_014398217.1\|6829651_6830527_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.30937e-14

>NC_017030.1|WP_014398216.1|6825412_6828658_-|PD-(D/E)XK-nuclease-family-protein
MPRPGRTLHVFPDAARRQAALRAERRARGIAVGTHLLTWDDFVHALGGARELNRRPCPAMAARAVVAGLGATLGPTPFGDYVREPAFARAAADVLLDLKAGRLSPRELQDAAEVLPPERRTRARVLARLYHLYEQRLAELGLADHEDVLRGAREALDRGAWPSGWDGVTGLVLHGVYDVRPSKLELLMGLAAACEARRVSLRVETPVGGSPVADAALAALFRAFENRGETMPHVDLFKADVTFEGRPFTDLGRHLFSPRAARDVLKGAVDGLAVWNATNAREEARVVARDVRRLIDSGSAPGDIAIAYRDLGPEAGWLAEALGDLGVPVRLPWGEPLALAGPVRLALELPVLMEDGFPAERVAELVSSRYVPSLSRGGPDAPATLFALAAARDDRLGATRGKGAYDVRLEGLARRMAAQGGKRKEDAVKVQAVRALRDRVMRLIDECRHIPQEAPAAESIAAWWKVVERLGLLDSAGPLEAREAGPLGARMEDARARDDAALAAFRQRMEALLRSLRAVGGGPRITRRVLGRWLADALRDVHLPARGPSTGAVEVLDLAEVPGRTFRHLFVAGLTEGRLPGRDPPSPLLGDAERVALNQHLTRDVFRLTGGEFDDRAPWRLTEDRLLFASALAAAEGSLSLSFAVKAAGGQEQVPSAFLEEVRRLTGHKGSTRALPPVLPLDEVLTLPELRRTVALEALAGLTFPSLRVTEPDPAGQLLKERFGTDDWFRSARELAHMEAARLRFFGREDELPGEFTGGVQGPQLEQKLRDTFHFGLERPLSASALSKFGNCGFQGFIAYGLKVAEPVVANEEFDARGRGTFWHRVMEEVFKELKEKKLLGQAPEDVPDDVLKGAVKKASKHFAELYHVGHHELWKLAGEKAHAMARRILTDPRRGLPFDPLVPEGFELRFGPAAEDERWSDVKLMVAEDAIVFEGQIDRLDTAGAEVGVIDYKTGRLDKRTLRENLLRSDFQLPLYLYAARVAGHVGAKNAAWFSLRTGDAIHLSSVLPPAELEDLLSTDPEVRQRVAEAAGLNLPNAVESLVRQLRKGDFPARPNDCGKCGYRAVCRITERRISDEGSG
>NC_017030.1|WP_014398215.1|6821747_6825416_-|UvrD-helicase-domain-containing-protein
MSDTAPHMLALEKNLALMAGAGAGKTYSLVTMTLHLFAGARQAEPLRPSRLCMLTFTDKAAAEMRKRVRERLDALAQGDVPLDAEKDLRASLARLERPFPTQDAWRKVREELGAATVGTFHSLCGQLLRRAPPAVGIDPAFEVLDELEAAGLLEDVTERVVLDALEGGDARVRELCAELGFSGSGFSDGLVAALMDVYGTLREEGLNAATARVGDGVADKAQLEALIEDCRRLCLDARAQDTKGEWSNLLSACEPALKGMTPDTFMQPGYFPTLRNVLLSEPRNLANLRKGAGACLKELLWKVKGKSDGSVRRLEDAYAAWRTAPFEATFRDLLTQVEDRHDAELTRRNVFDFTSLLVKARDLLRDHPEFRQQVQERLGALLVDEFQDTNRLQLELVLLLSEKREGGPRELAPDADLVASLPLEPAFLCAVGDRKQSIYEFRGADVSVFKVLADKIEAEGGMRGFLQNNYRSLPGVLSFFNRAFAGLLVAKEETPRPFEVVYEPETDDLSPTRPDLAEGPVVERLTLPEADTAPELREYEADAVARRLRVMLAPGAPPTVMAEDKKGLRPARGGDVAILFRTFTHLEEYRQALIRHGVPHRVLRGRGFYGAQEVRDLASLLALLADADDALAFAAVLRSPLVGLSDASLFRLAGDLPLSLGSPRLVDEEVRAAMSAREQSRLSRFLELIPVLRRERDRLGVHALLQAALDATGYREALAGSPYAEQASANVEKLLSLAARRDERGTGGCVAFARELRQLADSDPNEAQADLLDEGDPRAVQLLTIHRAKGLEWPVVIVPGMGGRRRSTSARAYFERSFGLALRPWMPDSLDTFTSERFEAVRAELKAREDAEYLRLLYVALTRAKDLLVLSGGEEKRAGTDTWWHRVDRRLDVDPDLRALANDVDVEQLPPPADPEPPTEEQLEQARIRLESALERMSDEASGAGAAVFTDAPVVASVRAVQDFLTCPRRYHQLHRLGLAIGSEPWEAPVRAAPLFVEPDGWLPVERPDQLVTRLLREVDLSLAGPDAEASERRAHLENLLRSAGRDPDEDELGDVLATVERFLDTTFARQLAVAPASTIHRGLDFVLDLDDAASVEGAVDLLWESPDGEAVAVLLRPGARHPRGPAACVHELTALALASARMVRDGVPVRVGVAFLGDASPEPEFLPAGSADAGAVRRLAEGVRALVQAEMSRAWPGWDKAACQALHCGFAEHCHPAPPAC
>NC_017030.1|WP_014398214.1|6820424_6821735_-|adenylosuccinate-synthase
MPNVVVIGAQWGDEGKGKVVDLLTEHAQVVVRFQGGNNAGHTLVVGGQKTVLHLIPSGILHPGKTCVIGNGVVVDPAVLVREIDALKPRGFLKDDAQLLISDNAHVIFPWHKLLDSFREKARGGSAIGTTGRGIGPAYEDKVARRGIRVRDLLHPERLRRRIDERLPGALEELKDLCAQAGVDVPTLETPQILAEFSALGDRLRPYVHDVSLFLSEQVRRGARILFEGAQGTLLDVDHGTYPFVTSSNCVAGNAAVGSGLGPTTIDKVMGISKAYTTRVGGGPFPTELSDELGDRLRKVGDEFGATTGRPRRCGWLDGVVLRYAVRVNGLWGLALTKLDVLSGIKTLSICNAYELDGQRVTELPGDYEDLERVKPIYETLPGWDEKIAGVRTFDELPEAAKRYVRRVEEVSGVPVVCVSVGADRGETVLLQNPFRS
>NC_017030.1|WP_014398213.1|6819462_6820368_-|tetratricopeptide-repeat-protein
MVRTRRFQLGVSAVVWLGTLAVPAWAQGTSAQPPAPEAKSAAQAARAPGPATDTPPGPGESQPQRTSQAVLAATRIRDGDALMRERRYREAAFAFLDAEHAAPDHVEARFKLGNALAVLGYYARAIEEWEAASRLTQDAAIRQSAQDNITRARVKQGELGASPQAVGQLPGSGPVADTTRAQARRAYEQGVQHISQRAYGPALQTLTQALQQEPLLTVAYIARGSANIGLRRYAEAAADYQFALKLEPGAASPLYGLAEAYRALGRNLEARDLYARYARSTAADVRPELKEESRQKAERLR
>NC_017030.1|WP_014398212.1|6818957_6819398_-|hypothetical-protein
MDGRDRTVEGKQPHQVFRPRRVLAAVMAAAGLLWLGIFAWLFHFDGVPLQTFLSAAFFVVFFGVAVTYYGRTRIEVDSRGITCRGMVRTRRFSFADIRKLDVLPGPVTVYAIRGSKGFVHFTSFFRHHRHLARLLVERAGLSPLPA
>NC_017030.1|WP_014398211.1|6818109_6818946_+|FHA-domain-containing-protein
MRFEFEHLGTPTPFELTEGHHLLGGGPDDHVHLEGLPPGLLTLRIDSGRLMVEAVRSFTVNAVRVLPGVSRLVVPGEVLGLPDGMCLRVLAEPSAPGRGVGTVAVLKGLLTDADLPPSRAATLTCLTGLDVGRCHALAEACTDIGRGDGAALRLRDRAVSRMHARIRREDPGFLLEDLGTPNGVFLNGVRLEAPAPLMDGDVVELGRSLLRFQAAFDEASGEARPVPRPMATVEEPAEAATPRPPEGGPRRLEGWIIAGAVALALGALLVTSLVAATG
>NC_017030.1|WP_014398210.1|6817345_6817981_+|outer-membrane-beta-barrel-protein
MSKGLLAGAAVVTVLAAGSAQAASTELRRSADMRGLTFLVGGGVEGYTSGLRDQIDPGLAYGVTVAIKPTNVLGLELGYTGAISNFNDSRVLATDTSGPDIVRNGAQAAVTLGLTATPLQPYVMGGLGLSRYNVRSAALGFQDDTVGNVPVGAGLRLHIGSFTADARVNYNFLFDQEFALTVPPSDVDLGGDETFSSGGRYVGTINLGATF
>NC_017030.1|WP_014398209.1|6815953_6817159_-|carbohydrate-binding-family-9-like-protein
MRLRSLALVPLLSSVLFVGGACRDEQAGPAHRTPKLPAPTTLRTLDAAPEGLTFRSGATFAGGAIVYLGARVTPEQATPGQPVRISHYFQAVRPPPQGFHFFAHVVDPESGQMLANADHEFQDGAAPLETWPVGRVLEDVHTVAMPATPARLVLGFWNDDGRLTVDDPRMQLGGNRMRGPLLGGEPPALPEYAVTRVKKAPVVDGALDDEAWKGAKPVTLAGSFDGRPVRLRTQARLVYDDANLYVAFDVEDPDIWGTMRNRDDSIYEQEVVEVFLDANADGRTYNELQVSPHNVIFDAYFPARRQGMDRSWDSGMKTAVKVRGTLDDASDRDEGWTVEMAIPFNRLAEVPHIPPQPGERWRFNLYRLEHHDRRQVEGQAFSPLFIGDFHALPRFGWLVFQ
>NC_017030.1|WP_014398208.1|6815683_6815944_+|hypothetical-protein
MISDDLDLRQLTTQLKARLGPGEPVGYLRGKSLMRDLLLDMRENRFSELEAEELVDTLEARGFVRFLGDPAERSVADAPWDISPHA
>NC_017030.1|WP_043321913.1|6813224_6815684_+|DNA-internalization-related-competence-protein-ComEC/Rec2
MVRYSWRDLGTRPLFFPALSLLLGALWATGTESFGGVFLLCALCLGGLGMALGPLPGAHLAVLGALALMGAGLSSLEARVDIPPSLKEGGSAVLEGELERVERFDGAVRLRLAVARAGSRQEPPTAARFHVSLSGRGERLDLHPGQRLRVEARLVPDAPPSNPGERDFSSARRRQGVAFTGGFAPGRVLALSPAPSWRLALEDVRGRLTTAVHGVAPSADAAALFLTLAAGQRADLDDSWEDAFSRAGLAHVLSVSGLHVAALALMTLALLRRGLVRLGGRSRTLEARRWAAPAAVPFVWAYVVFTGNQAPAVRSAVMASAVLLGLSLWRRADGLNGLSLAALVLVVWTPSSVVDLSLRLSFLAVLGLVLLSPALREALPLDRPAPSEPRVLKRWAAQARETVAQTLCASGAATLVGLPVVAAAFGRVSLAGLVSNIVALPLCGLLTGLAAGGAALFVVAPVVATPVLWAGAWASELLLVLTRGFAAVPFAAVEVPGLGPWLGGAYAVGLGAWALGSGRWRWLGMLVPGAVLGALLLPVLAPEPALRITFLSVGQGDAVVLRSQGHHALVDAGGVPEGADTGERFVLPFLKAEGVSRLDLAVLSHPHPDHALGLVSTLAQVPTERLWLSAGSADGPLSRKIISAAKGATVEEVEVGHPAFVLGEATLEVLGPPVDRELLEGANDRSVVLRVRHGDVTVLLAGDVEADGEAALEESLGPVTVLKVPHHGSRTSSTAPLLERTRPRHAVFCVGRRNRYGFPHPEVEARYRALGTECWRTDRDGAITLESDGEDVRLVSFLPRVDSAPPPVAGSGGQAQLER
>NC_017030.1|WP_014398217.1|6829651_6830527_-|alpha/beta-hydrolase
MVLAGCASTSGTGLREASDGPAQKTPAPFTQHRFTSADGTSLSYFRHGHGPALVWVCGTLSTWNDWRDVASRLSPRFTNFVLERRGRGASADGAAYALEREVEDVLALMQEAGPGASLFGHSLGGILALEAAVQRPPARLVLYEPPFPISRRIAREAVDLVRTTWKREGPDAALVAAQHHIFRMLTPELLEAFRQTPQWAKQLGMMETFLREIGAVADLPMGVERFRTMKTSTLVLLGDQSPHVLLAEPAQALTKVLPHASLRVLPGQGHVAHVSAPVLLAREVEGFISAR
>NC_017030.1|WP_014398218.1|6830923_6831832_+|LysR-family-transcriptional-regulator
MESLSAIGVFARVAETGSFASAARALGITPSAASKSVARLEERLGTRLFQRTTRRMHLTEQGARFHERCVRALTELRDAESELAHAAHTPRGRVRVSVPEMLALRLIIPNLQRFRREYPHLELDLDVNDHVADIVGDGLDAAVRCGELTDSRLMRRRLGPKRFILCASPAYLQAHGTPRSLDALQEHDCIRYRFVSTGRVESWALRQPASAPAPRIPETFVFNNSEAVTHAARAGFGIAQFVELMIRPELEAGTLRPFLREHSLERGALWLVWPQTRRTPPKVKALGDFLARLVEEDEAGAR
>NC_017030.1|WP_148282357.1|6831889_6832783_+|phosphatase-PAP2-family-protein
MPASYRTLATFCLLLLAPLSPAAAQDTSDAPRALRFNWTRDGIITGTAGVLWLSSESVFKDNLAPAQCRWCDRAPDGTDRLNRLDRWGRGIAGSTEASRKRADTWSNIIGFAGLPLGLLGTQYAVGRSSGASTEFFAQDATIMVQSAVLASVANQAVKFAVGRERPFVHVLPEAEKGLTEHPTDNNLSFYSGHTNLAFSLAVSAGTVAAMRGYKHQAVIWGVGLPLAASVGLLRMGADKHYLSDVLTGAVLGTAFGVAVPLLLHSRVDDTSPATTRASSVSLNPMVGTQMVGLSGAF
>NC_017030.1|WP_014398221.1|6836180_6839627_+|response-regulator
MSPPRVKDAPRVERFGPALPRSTFTGFAVAALAVLAIALLSYRTLKTRAATGQMVTHTLTVAAKLEEVLSTVKDAETGQRGFLLTGAESYLSPYTLAKKTLPENLSELRGLIADSAVQQQRLDRLEGAVTEKLAELQETVDLQLRGEGRQAIAVVQEDRGFAAMRTIRDTVEEMELEERALLTNRYGEFQESANLSLAVTLSGSALLCALLGIAAYTAARDFRARAIESWLQTAQTTLGTRMQGEQRLDRLGDNILRVLANALDAQVGALYVADTTHHFRRVAGHALPADLEARHDTLAPGEGLAGQALKEGRAFHLRDVPEGYLPISSGLARGRPRQVLIAPAQVDGQVNAVVELGFLHPVHPSDLELLQRVSDAIGVAVRASLDRARLEQLLEETQRQAEELQAQQEELRVSNEEIEEQSRVLKESQARLLNQQAELEQTNAQLEAQARLLENQRDDLALAQVTLSEKASELERTNRYKSEFLANMSHELRTPLNSSLILAKLLADNKEGNLTAEQVKFAQTIGSAGNDLLVLINDILDLSSIEAGRVDMQLESVGLQPFVDNLGRTFQPVATQKGLRFTTTVAPDVPSTLETDPQRLGQVLKNLLANAFKFTEAGEVALTVATEAPGRVTFSVSDSGIGIPRELQGLIFEAFRQADGSTHRKYGGTGLGLSISRDLARLLGGDVTVRSTPGEGSTFTVTLPLRPGTPVPAVREPPPAPPPGPVPPVAIPRPTPPPPRGLEDDRERLTSGSRVLLVVEDDARFALILRDLARELGFQCILASTATDGLEAALGHAPHAIILDMNLPDHSGLTVLDQLKRNPRTRHIPVHVLSASDRTRESLELGAAGFALKPVQREQLLDVFRTLETKSSPGPRRVLVLEDDARQRESIQKLLETEDVEVECAATAHDALQRLREHTFDCMVMDLHLPDLSGQDLLERMAAEEAVSFPPVIVYTGHTLSRDEEQQLRRFSRSIIIKGVRSPERLMDEVTLFLHQVESRLPPEHQRLLQAARDRESTLEGRRILVVEDDVRNIFALSSVLEPRGAKVAVARNGKEALALLTKSLAQPQLAVDLVLMDLMMPEMDGLTATREIRKQEAWRKLPIIALTAKAMRDDQEKCLQAGANDYIAKPLDVEKLLSLLRVWMPKG
>NC_017030.1|WP_014398222.1|6839635_6840463_+|chemotaxis-protein-CheR
MLDVATKEFDIELRLLLEALYLKYHYDFRGYAESSLKRRLVQAAEHFDCATLPQLQDRMLHEPALFPVLLDHLTVQVSELFRDPSYFRTLREHVVPVLRTYPSLKVWVAGCSTGEEAWSLAILLREEGLLERTLIYATDINPTALQRAEAGVYAVDRIASFTQNHHLSGARTSLSDYYTAAYGGAVFDRSLKAHIVFSDHSLATDSVFAEVQLLSCRNVLIYFNRELQERALGLFAESLCHKGFLGLGARESLRFSSHEASFTPVVPEDRLYQKR
>NC_017030.1|WP_014398223.1|6840478_6841090_+|chemotaxis-protein-CheB
MPTPRTTPAGRVDAIVIGASAGGVDALTHLLPALPTNFRPAILVVLNLPRSLPSLLPEVFSARCTLPVHEAGDEQPIQPGTISFAPPNYHLLVDRDAKGPLLALSTDAPVHFSRPAIDVLFESAAAIYGARLGGVILSGANADGALGLQAVKRRGGVTLVQATETARSPAMPEAALAAGPVDFVLPLEQMPAVFRAWGDGGAI
>NC_017030.1|WP_043321916.1|6841073_6842237_+|hybrid-sensor-histidine-kinase/response-regulator
MAVLSDLSILSKEPLPVASRVKCLLVDDLEENLLALSAVLRRDDVEVHCARSGAEALELLLLHEFALALVDVQMPEMDGFELAELMRGSERTRDVPIIFVTAGGGDPWRTFKGYEAGAVDFLFKPLEAHALRGKAEVFFQMHRQKQQLAQQLDTLAETLRLNEMFTAVLGHDLRNPLSAILTAADLLQRRSDDEAVKKTASRMMTAGKRMSRMIEDVLDLARARLAGGIPLRRGETDFGQLVQRMVQEHQTAWPRHRIEVRQDGDLVGDWDADRLAQVASNLIGNALQHGDAAEPVRILVDGTRDDALRFTITNVGVIPAHLLPFLFDPFRGGQQRRGRGEGLGLGLYIVQQIIHAHQGGVEVLSGTGPYTEFRVELPRKGVEVVKL
>NC_017030.1|WP_014398225.1|6842226_6843150_-|metallophosphoesterase
MPQDSLLVAALGDIHGRFHRVEAWLDALEQARGRRVDLVLAVGDVEAFRHADDHRRKAAKRAMPAEFAEYADGIRRVKRPLYFIGGNNEDFEALHDLPDGGELAPDVHYLGRAGLRTLGPLRVAYLSGIHAPRFIDQPLKRPTSLDTAKQAGYFRAPEVEQVSALRDVDLLLVHEWPRGIVQKARDERLVPERPLPSPWIGNPVTRKLVDTVHPKWVLCGHSHKPFAVALDSHGRTLSRVACLDQAARPDTAVFWLEFEGREAQRAGWGVSGVASWQAGQRWGLHTLPPLDESDGPGSVPADNGATA
>NC_017030.1|WP_014398226.1|6843234_6846177_-|choice-of-anchor-D-domain-containing-protein
MRGLRWLVLALVVAAATACERPTSQQARTGFAARPELLEFGAAAVGRTKTMTLRLANQGRASYRVEGARSSLPNVQVPAFEPFTLTAGAEHEIEVRFSPDVEGAVQGQLELFTDASGGAATQVPVSGRGVKALVEVPESALDFGNVNLGLVEMREVTVRNPSDVESPLVLSVEGADADQFSAGAGLPSTLAPHETRKVPVAFSPVRLGNAEAALHVAICDGCEPAVVTLKGMGVAGALEVTPLRVDFGRVAVGATAEERITVRNLGSEPLSYKGASLLEDPSGVFKVVSAPALPNDVLAPGAVVELRVAFTPAAAGRVKDGRVEVSVRKQKTTSPGPKVTLTGEGGASCVEVTPAHLSFGPVAFGMTATRDVTVHNRCREETTVTGLHLTTQAGGYFTLAQPPSSHPVAPGGTLKVGITFSPRAGVGSASSGQLAVTSTQRSSTSTDGVTLSGEGRAFAPCEYALPSVLDFGQVPVGSEVALGVTLRNTGSEACFLSALQLASGSDPAFRAATLPNSVLEPGKKMTLVVRFQPPTDGEFQGLAEGWVSHPTRGHPLVNLVGRGVQGCFSVQPTTVDFGINRLVCGPRTREFMAYNDCPGDVKVSGMKLEQPGHEFAVSGALPATIPAGGRVKLTAKYAPVEEGEDAATVRFTLKDGGVYNAGLVGRGLSKTDQTDRFVQQAEARVDVLFVVDNSGSMMEEQQSLGENFAAFLSAATAAQVDYRIGVTTTGLDPSPGGWSECPGGAQGGENGRLFPVDGSSPRIITPETPNAGGVFATNTHVGVCHWNEQGLDATYRALSDPLLYDLDDPRTPQSSDGNGGFLREEAKLAIIVLSDEEDFSSQPVSFYETYLLALKGNDPSKVSFNAVVGPEDLTTCTTSSSSGSRYMELARKLNGVVDSICTPNWATSLEKLSESAFGPNRAFPLSELPADPGAIAVQVDGVPVTDGWSYDARANAIVFDRLRAPAPGSVVEVTYPLGCP
>NC_017030.1|WP_014398227.1|6846596_6849470_+|excinuclease-ABC-subunit-UvrA
MSEPDVISIRGAREHNLKTVSLDIPKKKLVVFTGVSGSGKSSLAFDTLYAEGQRRYVESLSSYARQFLGQMEKPRYDTLRGLSPTISIEQKAASNNPRSTVGTVTEVHDYLRVLYASIGVQHCPNCGRKVGKQSAQQIVDEIMKLPAGTKLQVLAPIVTNRKGEHKDLLAEAQKRGFSRARVDGKVRELEERIELDKKSKHDIALIIDRLVLKPDLRTRLTDSVETALREGKGTLIITDEKGTLASDRVMSELNACPACGLSFGDLTPASFSFNNPLGMCTDCNGLGTRPEMDADLLVPDQSRSIRDGAIEPWASGMNRGEGWTADFVESLASAFKIDLDVPYAKLTKREKDVLMNGAKGKSFTVQWGDNGQYDMEWEGLLARTMRNFKTTTSEARKAELQKYFSDKPCPSCKGERLRPESRAVKVHQRTLVDLSRMTITEARTFLTQMGLSAQEEKIAQELLKEIRSRLSFLVDVGLGYLTLDRTASTLSGGESQRIRLASQMGSELTGVIYILDEPSIGLHQRDNGKLLTTLKRLRDLGNSVIVVEHDEETMEEADYLVDFGPGAGELGGQVVSQGTPKQVMADEKSLTGAYLSGRQEIEIPESRRPVNPKHQISIVGATENNLKNVDADIPLGIFTAVTGVSGAGKSTLINEILYPALARALYESREPMGKHKSIKGLEHLDKVIDIDQRPIGRTPRSNPATYTKVFDAIREVFAMTPEARTFGYGPGRFSFNIKGGRCEACEGDGVKLVEMHFLADVYVPCEVCNGKRFNEATLRVRYKGKNIAETLDLSVREAVDHFGAHKDIMRVLTTLTDVGLGYLRLGQPSPTLSGGEAQRIKLARELARVATGRTLYILDEPTTGLHFEDIRKLLSVLNRLVEAGNSVLVIEHNLDVIKSADWLIDLGPEGGSGGGNILATGTPEDVAKVEASHTGRYLKHVLGKARRARIGKRVDAA

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Crispr_ID: NC_017030_26

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_26

6969990-6970099

Orphan

Consensus_repeat	Method
AAGGGCCGGAGCGCCTGAGCACTCCAGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_26

>merge|NC_017030|26|6969990-6970099|CRISPRCasFinder
AAGGGCCGGAGCGCCTGAGCACTCCAGCCCGTTCGCTGCATCATCGCGGCGGGGACGCGGCAGCGCGCCCTCGACGCAAAAAGGGCCGGAGCGCCTGATGCACTCCAGCC

>NC_017030|26|21|6969990-6970099|CRISPRCasFinder
AAGGGCCGGAGCGCCTGAGCACTCCAGCCC	GTTCGCTGCATCATCGCGGCGGGGACGCGGCAGCGCGCCCTCGACGCAAA
AAGGGCCGGAGCGCCTGATGCACTCCAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014398334.1\|6970129_6971842_-\|polynucleotide-adenylyltransferase-PcnB	unknown	unknown	gnl\|CDD\|130997
NC_017030.1\|WP_014398342.1\|6980391_6981816_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238742
NC_017030.1\|WP_014398337.1\|6974311_6975622_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340888
NC_017030.1\|WP_014398329.1\|6964111_6965968_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014398326.1\|6960541_6961366_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398339.1\|6977790_6978687_-\|outer-membrane-beta-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|275358
NC_017030.1\|WP_014398330.1\|6966096_6967215_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014398335.1\|6972223_6973270_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227187
NC_017030.1\|WP_014398331.1\|6967211_6968153_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_017030.1\|WP_014398338.1\|6975733_6977785_-\|adventurous-gliding-motility-protein-GltC	unknown	unknown	gnl\|CDD\|236776
NC_017030.1\|WP_014398343.1\|6981980_6982484_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|376377
NC_017030.1\|WP_014398341.1\|6979782_6980289_+\|adventurous-gliding-motility-lipoprotein-CglC	unknown	unknown	unknown
NC_017030.1\|WP_014398325.1\|6959605_6960403_-\|di-trans,poly-cis-decaprenylcistransferase	unknown	unknown	gnl\|CDD\|259850
NC_017030.1\|WP_014398324.1\|6958781_6959609_-\|phosphatidate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|366491
NC_017030.1\|WP_014398328.1\|6962282_6964088_+\|DUF4215-domain-containing-protein	unknown	unknown	gnl\|CDD\|200169
NC_017030.1\|WP_014398333.1\|6968604_6969810_+\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|176459
NC_017030.1\|WP_014398332.1\|6968149_6968563_-\|YjbQ-family-protein	unknown	unknown	gnl\|CDD\|223509
NC_017030.1\|WP_043323830.1\|6978683_6979511_-\|outer-membrane-beta-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|275358
NC_017030.1\|WP_014398336.1\|6973266_6974301_-\|phosphate-acyltransferase-PlsX	unknown	unknown	gnl\|CDD\|235414
NC_017030.1\|WP_148282361.1\|6961596_6962286_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|338048

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014398334.1\|6970129_6971842_-\|polynucleotide-adenylyltransferase-PcnB	gnl\|CDD\|130997	TIGR01942, pcnB, poly(A) polymerase. This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).	1.06228e-93
NC_017030.1\|WP_014398342.1\|6980391_6981816_+\|VWA-domain-containing-protein	gnl\|CDD\|238742	cd01465, vWA_subgroup, VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known.	3.30124e-40
NC_017030.1\|WP_014398337.1\|6974311_6975622_-\|MFS-transporter	gnl\|CDD\|340888	cd17330, MFS_SLC46_TetA_like, Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.46884e-73
NC_017030.1\|WP_014398329.1\|6964111_6965968_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.82554e-102
NC_017030.1\|WP_014398339.1\|6977790_6978687_-\|outer-membrane-beta-barrel-domain-containing-protein	gnl\|CDD\|275358	TIGR04565, hypothetical_protein_N47_G32130, outer membrane beta-barrel protein. Members of this family are outer membrane beta-barrel proteins, as inferred by distant homologies to other families (e.g. pfam13505) and by the concentration of aromatic residues, especially Phe, in the OMP signal region, which is flush with the C-terminus in some members, but followed by a few residues in others. Members have variable insertions and deletions, affecting scores, so this model does not cleanly separate all members from all non-members. Members are common in the Myxococcales, with five occurring in Myxococcus xanthus DK 1622.	3.35457e-44
NC_017030.1\|WP_014398330.1\|6966096_6967215_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.28396e-63
NC_017030.1\|WP_014398335.1\|6972223_6973270_-\|hypothetical-protein	gnl\|CDD\|227187	COG4850, COG4850, Uncharacterized conserved protein [Function unknown].	8.76467e-07
NC_017030.1\|WP_014398331.1\|6967211_6968153_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	8.11054e-81
NC_017030.1\|WP_014398338.1\|6975733_6977785_-\|adventurous-gliding-motility-protein-GltC	gnl\|CDD\|236776	PRK10856, PRK10856, cytoskeleton protein RodZ.	5.19244e-07
NC_017030.1\|WP_014398343.1\|6981980_6982484_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	6.16241e-81
NC_017030.1\|WP_014398325.1\|6959605_6960403_-\|di-trans,poly-cis-decaprenylcistransferase	gnl\|CDD\|259850	cd00475, Cis_IPPS, Cis (Z)-Isoprenyl Diphosphate Synthases. Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS) catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl diphosphates. A few can also catalyze the condensation of IPP to trans-geranyl diphosphate to form the short-chain cis,trans- FPP. In prokaryotes, the cis-IPPS, undecaprenyl diphosphate synthase (UPP synthase), catalyzes the formation of the carrier lipid UPP in bacterial cell wall peptidoglycan biosynthesis. Similarly, in eukaryotes, the cis-IPPS, dehydrodolichyl diphosphate (dedol-PP) synthase catalyzes the formation of the polyisoprenoid glycosyl carrier lipid dolichyl monophosphate. cis-IPPS form homodimers and are mechanistically and structurally distinct from trans-IPPS, which lack the DDXXD motifs, yet require Mg2+ for activity.	2.00769e-124
NC_017030.1\|WP_014398324.1\|6958781_6959609_-\|phosphatidate-cytidylyltransferase	gnl\|CDD\|366491	pfam01148, CTP_transf_1, Cytidylyltransferase family. The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.	3.41561e-55
NC_017030.1\|WP_014398328.1\|6962282_6964088_+\|DUF4215-domain-containing-protein	gnl\|CDD\|200169	TIGR02232, myxo_disulf_rpt, Myxococcus cysteine-rich repeat. This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP\|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.	7.8473e-06
NC_017030.1\|WP_014398333.1\|6968604_6969810_+\|DNA-polymerase-IV	gnl\|CDD\|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	1.40068e-169
NC_017030.1\|WP_014398332.1\|6968149_6968563_-\|YjbQ-family-protein	gnl\|CDD\|223509	COG0432, COG0432, Uncharacterized conserved protein [Function unknown].	1.68208e-58
NC_017030.1\|WP_043323830.1\|6978683_6979511_-\|outer-membrane-beta-barrel-domain-containing-protein	gnl\|CDD\|275358	TIGR04565, hypothetical_protein_N47_G32130, outer membrane beta-barrel protein. Members of this family are outer membrane beta-barrel proteins, as inferred by distant homologies to other families (e.g. pfam13505) and by the concentration of aromatic residues, especially Phe, in the OMP signal region, which is flush with the C-terminus in some members, but followed by a few residues in others. Members have variable insertions and deletions, affecting scores, so this model does not cleanly separate all members from all non-members. Members are common in the Myxococcales, with five occurring in Myxococcus xanthus DK 1622.	1.21428e-35
NC_017030.1\|WP_014398336.1\|6973266_6974301_-\|phosphate-acyltransferase-PlsX	gnl\|CDD\|235414	PRK05331, PRK05331, phosphate acyltransferase PlsX.	2.04414e-125
NC_017030.1\|WP_148282361.1\|6961596_6962286_+\|hypothetical-protein	gnl\|CDD\|338048	pfam11617, Cu-binding_MopE, Putative metal-binding motif. The seqeunce of structure 2vov is not matched in any other sequence either in UniProt or in NCBI (Sep2014). The model is of a short repeat not found on the G1UBC6 - 2vov - protein. The presence of conserved cysteine residues and the lack of hydrophobic residues suggests that this repeat might be a metal-binding site, perhaps for zinc or calcium ions.	6.77748e-07

>NC_017030.1|WP_014398333.1|6968604_6969810_+|DNA-polymerase-IV
MRAILHVDMDAFYASVEQRDNPSLRGKPVIVGGHAQRGVVVAASYEVRPFGVRSAMPMARAVKQAPHAIVVKPRFSAYAEASEQVFAIFERYTPLIEPLSLDEAFLDVTASVGLFGAAADIAKRIRKEIAHELNLPASAGIATAKFVAKIASDLAKPNGQREVRPEETVAFLAGLPVSRLWGVGPKTEEAMKRAGLVTIGDVATRDVDWLEERFGAASAKHLWELSHGIDARDVVPDRAAKSVGAEDTFDEDLTGPEALKPHVHAQALRVARRLRRASLKGRVVQLKLKFADFTLITRRVTLREATDDGQVIYRAALELLERAHEGKALRLTGVSVQLDEDEPQLGLFPAAAPKSSKLNEAMDRIAARFGSKAITMADIAGAEASDDDQHRSEKPVDKPKR
>NC_017030.1|WP_014398332.1|6968149_6968563_-|YjbQ-family-protein
MKTLTEYLWFETKARRELVRLTDTVAALLKKSGIQEGMVLVSAMHITAGVFVNDDEPGLHEDIWDWLQHLAPHGPDYRHHRTGEDNGDAHLKSMLVHHQVLIPVTAGKLDLGPWQQVFYAEFDGQRRKRVIVKVMGD
>NC_017030.1|WP_014398331.1|6967211_6968153_+|RluA-family-pseudouridine-synthase
MSTTTTHTLTVDAAKAGQRVDLFVGEALGLSRARMKRLFEEGQVRVDGRPAKKGLTVTEGQKVSVTVEEAPREAVPDTDFPLVVLHEDPSLLFVDKPAGRPSHPLQPGETGTVANALVARYPEVAQASQDPREGGLCHRLDVETSGVLAVARTREAWTRVREAFSNRAVDKRYVALVTGPLADEGEVEVPLRHHPRHPDRVEPAPYGAEDAREALSHFRVLARSGDYSLVEVKILTGVLHQVRAHLAGVGAPLVGDALYGGREAPELGRFFLHARSLTVPHPVTNQPVKVESPLPPDLVAELGRHGLSWPVAG
>NC_017030.1|WP_014398330.1|6966096_6967215_+|serine/threonine-protein-kinase
MPPKAIGPYRVLETLGSGGAGTVYRALDRRSNDEVALKLLSTGGPSLDDRAARRLAREFETLADLSHPNVVKVFEAGVHAGQPYLAMELIEGLTLRHYLDVSFNDLHTPTPSSRFPLTLRRTADDDFGSADGPDDDADDASEDDGTFDLNAFAEEAPSEDLASFHGAGDDDSASDGMPVVDPRRAAPRAPQPPARPATPKMADLNRPERMGKLKDAMLQVCEALAYIHGHGLVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAGITADGKLVGTYRYMAPEQILGEPLDGRSDLYSLGVILYELMSGRPPFDAKTPHELWRQVLETEPPPLLALNLHGDPQLARVAHRLIRKEPDDRFQTAEEVYEALSE
>NC_017030.1|WP_014398329.1|6964111_6965968_-|serine/threonine-protein-kinase
MQLGKYQLVRKLASGGMAEVFLAKAAGPRGFEKTLVLKRILPHLAEDEAFVEMFLGEAQLAARLDHPNVVQIFDFGEVDGSYFLAMEYIDGPTLRRLIKRSAELKQPLPPGVCAKMVAAAAEGLAFAHELADPETGAPLGLVHRDISPENVLVSRQGAVKVVDFGIAKVAGQSHRTATGVVKGKVAYMPPEQLQARPMDGRVDVYALGIVLYELLTGKRPFDATTDVSMMQAILFEPFVPAVQRRPDLPESMQRILEKALAKDREQRYPDCRAFQADLERFVLSLGEPVGAYQISRLVAQVMEGVEATPVSPTPAKGRVTAPVALVPESATTPMPARVGTAWEPLASRGSMAAPAVTASQHDIPSSRFDAATDPATPSAGSLLRNSSRAQPQEEVSKVAASEEPVLAGAVRSPRRKLVGAMVAVSVLGLAGGLAVAGRGEKAAAPASAPAPVARTDDAPVKPPEPKVTPVVPEARVEPVATETVDSGTPAVVAEVKPATENSTEVRDAGVVTEVAPTPRPTVAVKPATTSPVTPPVRRVATPVRRELPKGKVEFRVRPFGTVYLDGKNLGQTPFAAVEATEGSHQVRVVNKDLGKDVTRAFEVKAGQDNVFKLNLAAE
>NC_017030.1|WP_014398328.1|6962282_6964088_+|DUF4215-domain-containing-protein
MTPQSSHRQLASRAWMVLAFLLPLLTVCSDPPDRTCPSGLLCPEGRQCAAKQDICIPSDCGDGAVEDGEACDDGNVIDGDGCNRTCTSLEVCGNGVVDIAKGEKCDDGNTLGGDACSADCRSSEVCGNGVRDTAVGEVCDDGNNVSGDGCSADCLSQETCGNGYTDAAKEERCDDGNTEDGDGCSADCHVAEVCGDGARQGREQCDTQGESGTCNANCTLPACGDGIVNAAAGEQCEHNNTSSRSCPYGQATCTVCREDCMAFVAAQGNVCGDGARDAAYEACDDSNTTTETSCPYGQASCQRCSRDCQSALALRGNVCGDGIQDPSAANEACDDGNTTTETACPYGVASCVICRSDCKETLSVTGNTCGDGVRDPVNEACDDGNVSTETTCPYGTESCQRCSSDCKTALSLQGNVCGDGVWAPSNEACDDGNTLTCGSCSADCKVKTLQAATGTITASASTNMNDGETFTISDGINTPVTFEVDRNGSLQNPAHQRVQVENNTPATQVALIIRDAINAVAEPFEIEASVVIGTFVVNVTHNLKGSIGNQTMTEKITNTAFKVSGMNGGSGYDCAQGTKCVGNEDCAYDLICDGARVCSPP
>NC_017030.1|WP_148282361.1|6961596_6962286_+|hypothetical-protein
MSTLVLGRQEAQPGEPLRVAVLLADTWRGDVLFQADAFEQTCDTAPVASEVLPAVPTDKGQVTQARLDLTAEDLDQDGFVSAARGGTDCDDANANIHPGAVERCNGVDDNCVDGERDAVDAPTWYADTDLDGHGGTPVRACVAPAGAYAVRDDCDDRNRLVHPGQAESLCDGKDDNCNGDVDEGFNVGAPCTTAQSLPGRLTCDTAIPTRAVCTAIPSVTGTDSSEVLE
>NC_017030.1|WP_014398326.1|6960541_6961366_+|hypothetical-protein
MKTPHGSPSFRVLGGLLGFWVFGVGPAFGQAAGTGSAASRPAGTYFDAAMAEAARLYEDLESEQALAAVTRARRLARTDAERSSAAIYEGVILADLGRRDEALASFRAGLLLAPEAKLPAKVSPKVEGDFESIRSAVRQERAAVAKPVDAPVVETPAALSPPQVAVAPAPAPGVDLKAEARERGMRRVPTVSWVLLGTGVVAGGVGSIIGLQSRGNVSSARDADLSADVSGHLDDARGQAVVANVLFGTALAAAAGAVTTYFLSGESTASAGGQ
>NC_017030.1|WP_014398325.1|6959605_6960403_-|di-trans,poly-cis-decaprenylcistransferase
MDRPPTVLPTALEVQVRARPLPRHVGIIMDGNGRWAELRGQPRLEGHREGSVSVREVTRAARRLGVQALTLYAFSSQNWARPPEEVAGLMDLLREYLESERAEILDNGIRLNAIGEVDKLPRYVREPLERLRADSAHNTGMVLTLALSYGGREELLRAARDLAQAAARGELDPAHLDADDLESRLWTAGLPPVDLIVRTSGEQRISNFLLWQLAYAELCFTDALWPDFRTEEFLRCLSQFQGRERRFGLTSAQVNRDDTPQRAKA
>NC_017030.1|WP_014398324.1|6958781_6959609_-|phosphatidate-cytidylyltransferase
MNEKNKNLLIRVVTGITLLPLVLLLLFLGGYYSAILLAGAAAVCAGEYYLITQKRLGAAAWVGMAFAFVMPLLPLRDAARTGEAAFWLTSVFFFFAWIYNLFRGVLAEAPTRAAHLVTGFLYGSIGLTALSALRLLPEGHAWVICALTITWANDTLAYFAGRFLGKHKLYPAVSPNKTWEGFFGGMVGSVLGMFVAKLGFFPIFTVWDCVVLGILGGLLGPVGDLCESMLKRAYGVKDSGKLIPGHGGVLDRIDALIFNAPLVFVYVQFVRHLLP
>NC_017030.1|WP_014398334.1|6970129_6971842_-|polynucleotide-adenylyltransferase-PcnB
MSSPLDLTGSEERTERTEAQVPADSAEHPSEHETPSRADPAPSEPPFAADAAEDDGFDDDDDAEDAGPEVSDEIRAATEALKAAEAEDAQAAAEAGDEAEEPEAVILEPEPEPASNEPELQAPTTTRTGEPAEIDPDEMDPDALKVVLRLHQHGHQAYLVGGCVRDLLLGKKPKDFDVATSAHPGEVRAIFRNCRLIGRRFRLAHVYFKGGKIVEVSTFRANPTELEPAAGAEEGQSGEDLLITHDNVFGTAQQDARRRDFTINGLFYDASEGRVIDYVRGRRDLDERFIRTIGDPEIRMREDPVRILRAVRFAAKLDLDIESRTYAAMEGAVEDLPRCAPARLLEETFRLIRGGVSAPALKLLAALDALKILLPPVDAYLRENGKEGEKTFYAFAQALDKRVSAGEVLDDAILLAALLVPISRAQPPVEESQDEGRASVSRVIEDLLAGFVESARLPRRIAERCRMLLLMQRTLSGERRRKTGAFRRHPLFNEALAVYAMTVEATGEGREALEAWQAGEVPPPRAGAAGGADAEGPRRKRRRRRRRRSGSGSGEGGGAGASSGSDAGEG
>NC_017030.1|WP_014398335.1|6972223_6973270_-|hypothetical-protein
MSLPDRIDPRPPRRIYRWDLDKTYLQTDFESLRDLFRTAFQKAHEKVAIPGASALIRELAEQGDSRLCIVSGSPKQMRAVLEEKLKLDGIQWDEFVLKDNVGNLLRGRFRALRGQVGYKLPAILESRVNAPVEAEEVLFGDDAEADAFIYSLYADLIAGRVDERVLSQVLEAGGVYPDDAARVHEAWKKIPIADPVRRIFIHLDKLTPPAHFTPYGPRVVPIFNYFQAALVLLADGHLTAPQVLKIAVEMVQTAGHNIITLSNSFQDLLRRGLPLQQAAIALSQAMEGPNALLKAMRPMPDILAAFSKRLAALGTQPPPPRVQAVDYVSLISHALPRTHKGRTLKPPT
>NC_017030.1|WP_014398336.1|6973266_6974301_-|phosphate-acyltransferase-PlsX
MVGKPQHITIAFDVMGSDHGPAEVVRGAAQLSLESPHIHALLVGDRPVIDEALAGIKHNGERISVHHAGDYVGMDEKPGEALARKPESSVAVAARLVAEGEAHALVSAGNTGAGVLACKRHFQLIPGVRRAALATVYPTRGVRGAKQDPFSLILDVGATVEATAEDLVAFAVMGSAYARIISRNERPKVALLSNGVEPQKGPPRVVEAHQRLSQMAGLNFTGNVEGIDIPRGTVDVIVTDGFVGNVCLKMLEGVHDTVMELAQYAYKESLRWRAGLAMLSSGIERLKDITDWEQYGGAPILGFDRIFIKAHGRSKARAIANAGKVAAKAVANELGTAIQEGLAK
>NC_017030.1|WP_014398337.1|6974311_6975622_-|MFS-transporter
MAREASLRVVFGIAVLDLIGFGILIPQLGVYGVRFGASPFAVGLLVAVYSLMQLVAAPIMGRLSDRFGRRPVLLISQVGSLLGYVLFAFAHTLPLLFLSRVIDGVSGGNVSTAQAVVADITKPHERARGMGIIGAAFGLGFVLGPALGGVLGAWGGNLAIGLFAAGLSALNLINTWFFLPETRRADSPSATTRSMRGAAAVLTLPVVGRCVVLVLLYTVAFAQMEGTFSVYLLTRFLSSGPVPLEGGWLVHAVHPDAAVLKEASLRSGALFAVVGVLSALVQGGLVRRLVAAHGAPGQGAEGAPGGRGGREAPVAVVGFGLTAAGLALLPVAPSYGWLFPVMGLLAVGSALVTPCLSALVSLHAPMERQGAVLGAYQASGSLGRIIGPALGGLLFTRLGPTAPYGTGAVLVALGGLLALSLVTQVRMSGAGAEQSS
>NC_017030.1|WP_014398338.1|6975733_6977785_-|adventurous-gliding-motility-protein-GltC
MRTHRFLRLAVLGLTLAYTAPTLAQSFEGLDLAGQSKKKKKGASSKASSKKKTSAKRGKGKATAPAEEVDESSTATSEPAPAGNPATPPAAVTTTPAPSAMPAAPAAKPTPPAKPAAQGSPGLGLDLTGDNDKPPAPTMTFDAVDVSGKTADRQRLDAAISLFKNDEYEKAAMASHELLGDPKLQGLHVEARYVLAKSLYRMGLYHSSLGEFSKILAAGPSTKFFKTSLEWLFFISRKTQNETVILDEIARYANYEFPEKFRNEFRYLLARYHFVRGRALDQVGQTENADKSFEEVKRLALTIPRTDAFYPRAKYLEGLAFFRNGTRNKDAASKRGNTDVLASVEAMKEVVRLTRPMAGRTGEAAKLDKSLRELAFMQLARTHYGMQQNRFSIFYLNKVERGNTQWLEALFESSWANYRIGQYEQALGNLITLSSPFFREEYFPEALILKAVIYYENCRYRESNLILQDFERTYLPVHDELDGLVKKNMEASEYYTVLADVQKKNKDGLEKNGTDVILERILRLALTDQDLKKTNDSILELEGEMDLFSNKGDTFKYSELTKQLLEELKVQRTSLISKAGIMAKGKLESELGALKLLLANGLRIKFETTTKEKEFLEEQLKAGGRTAIVKKYKFSVAVADDQLYWPYEGEYWRDELGTYQYTMTKGCIERDTANRQMQSAEAM
>NC_017030.1|WP_014398339.1|6977790_6978687_-|outer-membrane-beta-barrel-domain-containing-protein
MKPAFRLLLTLCAGVPALAAADQAPAPAPAAAAPAAPATPAPAPAAAAPKTAANSNPPSTSQEEEAGDVSEVDKDALGPLRERIRPVSGHMFLKKGRFEVSPSASITIRDAFFKKYLFGGTVTYFPMETLGVGLRGGYALNSVAGSAQKCTFTPGEGGDTRGCSAPTREELDGYAPGQMTLMGGVDVQWAPIYGKLSLLAEKFVHFDMYGVVGATVVQYKGPAESLSDGTPVAGSKSYLTGGGNVGVGLRFFFNRWMTLRTELRDIIYVEKGRDPTPNYLRNQILFELGLSFFFPSGS
>NC_017030.1|WP_043323830.1|6978683_6979511_-|outer-membrane-beta-barrel-domain-containing-protein
MNRPTLLLALSLMWPALAPAQNQPGMGLDLTEDAQAKPPEENPAPPPDEEARPASPPAATPAKEIPVEALMPLTDITQDDRVKSVQRKVYLKKNRLEISPFVSLSVNDPFYSKFGGSLRAAWYLSDTLAISARGSLIQVIPSDDVSTAKRTFNSKIYASVPNWSAMGDLEWAPLYGKVSFLNSILHFDGYLLGGMGVVRTETSALPDRGLNPAFDLGLGMRFVTKDYLAVNVALINTSYVDQPLGSSKGALQNVMTLNAGISIFLPLKSTGRESE
>NC_017030.1|WP_014398341.1|6979782_6980289_+|adventurous-gliding-motility-lipoprotein-CglC
MFVRTALFLSAALMLGGCDVTTELGKPCQLVRRATAEEQAAQGRKFMEIQEKDIAVDQDFISFGSLDCEDLVCVRDDLSPRSDNPEAFALGYCSKECVQGTTTGCEITRTVGDVEEGLKERMTCRPLLLDQDTLDAIKIADEGFYRRTFGENNSPYFCAGAVSASQGT
>NC_017030.1|WP_014398342.1|6980391_6981816_+|VWA-domain-containing-protein
MNRTVLFLALAGGLALTALVLGMPRGGGLPPTPHVVVTPPPPVTPPGPRASTGSLQVTSRLSHPYVPVGPSETYVTVDLTGAEVPGAKRSPVNLAVVIDRSGSMSGYKLQQAKQAARHLVTLLRDEDRLAIVHYGSDVKSLPSLPATAGNRERMLQFIDGIWDDGGTNISAGLSVGRTQLASAMGGTATVNRLILMSDGQPTEGVSDEEGLKNVVREIRASGITVSSIGVGTDFNEDLMQAFAEYGAGAYGFLEDASKLSTLFQRDLQQATTAVARNVELSFELPPGTSLGEVLGYRAHQAGNTVRVALPDFSAGQVERVVARLHVTGTAPGQSVQVAGLKVAYTDLLVQKNVEDQSTLAAVATHVQEEIVQRQDKEATVYAARARSAQNLQKAAEAMSQGKKAEAKGYLSQNQALFEEAGAVAGAAAVAADQAEQSRAMQEYDDADSYEAQKAAVKNSKVKALKSFGRMGSTY
>NC_017030.1|WP_014398343.1|6981980_6982484_+|5-(carboxyamino)imidazole-ribonucleotide-mutase
MAASASTPWVGVIMGGKSDLEHLQPAIDILAELRIPHEVRVVSAHRTPDWMMEYASSAEGRGLSVIIAAAGGAAHLPGMVSSKTLLPVLGVPMPTTVLSGFDALLSIVQMPKGVPVGTQAIGKPGAANAALHAAAILALKYPELRERLAAWRKARTDEVLAQREVAG

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Crispr_ID: NC_017030_28

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_28

6987908-6988005

Orphan

Consensus_repeat	Method
AAACCTGTCCGACTGTCCGACAGGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_28

>merge|NC_017030|28|6987908-6988005|CRISPRCasFinder
AAACCTGTCCGACTGTCCGACAGGTTTCGGCAAGCCACGCCGGGCGGACCTTCCCCTTCGCTTGAGAAGCGAAAACCTGTCCGACTGTCCGACAGGTT

>NC_017030|28|23|6987908-6988005|CRISPRCasFinder
AAACCTGTCCGACTGTCCGACAGGTT	TCGGCAAGCCACGCCGGGCGGACCTTCCCCTTCGCTTGAGAAGCGA
AAACCTGTCCGACTGTCCGACAGGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014398355.1\|6993914_6994883_-\|homoserine-kinase	unknown	unknown	gnl\|CDD\|270702
NC_017030.1\|WP_014398357.1\|6996634_6997126_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398342.1\|6980391_6981816_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238742
NC_017030.1\|WP_014398345.1\|6983628_6984105_+\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NC_017030.1\|WP_014398339.1\|6977790_6978687_-\|outer-membrane-beta-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|275358
NC_017030.1\|WP_014398356.1\|6995027_6996638_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_017030.1\|WP_193352512.1\|6990406_6992770_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276808
NC_017030.1\|WP_014398347.1\|6985546_6987325_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225110
NC_017030.1\|WP_014398353.1\|6992824_6993352_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_148282362.1\|6988987_6989323_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398338.1\|6975733_6977785_-\|adventurous-gliding-motility-protein-GltC	unknown	unknown	gnl\|CDD\|236776
NC_017030.1\|WP_014398343.1\|6981980_6982484_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|376377
NC_017030.1\|WP_014398341.1\|6979782_6980289_+\|adventurous-gliding-motility-lipoprotein-CglC	unknown	unknown	unknown
NC_017030.1\|WP_014398348.1\|6988195_6988954_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398344.1\|6982480_6983623_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
NC_017030.1\|WP_014398337.1\|6974311_6975622_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340888
NC_017030.1\|WP_043323830.1\|6978683_6979511_-\|outer-membrane-beta-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|275358
NC_017030.1\|WP_014398354.1\|6993425_6993899_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379639
NC_017030.1\|WP_014398350.1\|6989431_6989983_-\|DUF192-domain-containing-protein	unknown	unknown	gnl\|CDD\|376876
NC_017030.1\|WP_043321926.1\|6989979_6990381_-\|TIGR02266-family-protein	unknown	unknown	gnl\|CDD\|274060

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014398355.1\|6993914_6994883_-\|homoserine-kinase	gnl\|CDD\|270702	cd05153, HomoserineK_II, Type II Homoserine Kinase. This subfamily is composed of unusual homoserine kinases, from a subset of bacteria, which have a Protein Kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	6.36059e-78
NC_017030.1\|WP_014398342.1\|6980391_6981816_+\|VWA-domain-containing-protein	gnl\|CDD\|238742	cd01465, vWA_subgroup, VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known.	3.30124e-40
NC_017030.1\|WP_014398345.1\|6983628_6984105_+\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	2.12192e-68
NC_017030.1\|WP_014398339.1\|6977790_6978687_-\|outer-membrane-beta-barrel-domain-containing-protein	gnl\|CDD\|275358	TIGR04565, hypothetical_protein_N47_G32130, outer membrane beta-barrel protein. Members of this family are outer membrane beta-barrel proteins, as inferred by distant homologies to other families (e.g. pfam13505) and by the concentration of aromatic residues, especially Phe, in the OMP signal region, which is flush with the C-terminus in some members, but followed by a few residues in others. Members have variable insertions and deletions, affecting scores, so this model does not cleanly separate all members from all non-members. Members are common in the Myxococcales, with five occurring in Myxococcus xanthus DK 1622.	3.35457e-44
NC_017030.1\|WP_014398356.1\|6995027_6996638_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	9.5294e-07
NC_017030.1\|WP_193352512.1\|6990406_6992770_+\|hypothetical-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	0.00145237
NC_017030.1\|WP_014398347.1\|6985546_6987325_+\|GGDEF-domain-containing-protein	gnl\|CDD\|225110	COG2200, Rtn, c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms].	3.20806e-62
NC_017030.1\|WP_014398354.1\|6993425_6993899_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	1.27231e-08
NC_017030.1\|WP_014398338.1\|6975733_6977785_-\|adventurous-gliding-motility-protein-GltC	gnl\|CDD\|236776	PRK10856, PRK10856, cytoskeleton protein RodZ.	5.19244e-07
NC_017030.1\|WP_014398343.1\|6981980_6982484_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	6.16241e-81
NC_017030.1\|WP_014398344.1\|6982480_6983623_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	8.41634e-154
NC_017030.1\|WP_014398337.1\|6974311_6975622_-\|MFS-transporter	gnl\|CDD\|340888	cd17330, MFS_SLC46_TetA_like, Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.46884e-73
NC_017030.1\|WP_043323830.1\|6978683_6979511_-\|outer-membrane-beta-barrel-domain-containing-protein	gnl\|CDD\|275358	TIGR04565, hypothetical_protein_N47_G32130, outer membrane beta-barrel protein. Members of this family are outer membrane beta-barrel proteins, as inferred by distant homologies to other families (e.g. pfam13505) and by the concentration of aromatic residues, especially Phe, in the OMP signal region, which is flush with the C-terminus in some members, but followed by a few residues in others. Members have variable insertions and deletions, affecting scores, so this model does not cleanly separate all members from all non-members. Members are common in the Myxococcales, with five occurring in Myxococcus xanthus DK 1622.	1.21428e-35
NC_017030.1\|WP_014398350.1\|6989431_6989983_-\|DUF192-domain-containing-protein	gnl\|CDD\|376876	pfam02643, DUF192, Uncharacterized ACR, COG1430. Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for Structure 3pjy shows that there is much similarity with the other solved structure, Structure 3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. Structure 3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).	5.45096e-48
NC_017030.1\|WP_043321926.1\|6989979_6990381_-\|TIGR02266-family-protein	gnl\|CDD\|274060	TIGR02266, gmx_TIGR02266, Myxococcus xanthus paralogous domain TIGR02266. This domain is related to Type IV pilus assembly protein PilZ (pfam07238). It is found in at least 12 copies in Myxococcus xanthus DK 1622.	5.53966e-36

>NC_017030.1|WP_014398347.1|6985546_6987325_+|GGDEF-domain-containing-protein
MSLPSPSKPAPPPPWLWNGDEPRVATVFQPIVDLLSGEVLGHEVLSRGLGPVESPNELFNRARVEGFTYELERACWTAAVRRIATLPEAQRRGPFFFNVSPDVLSDERFGGASTLELLRQHGLSPQQLVLEITERSTFEDTEQLRMLARRYAEQGFGIALDDFGAGHSGLVTLVHSAPDFIKLDQALVRDIHLHTYRQHLVKSLVAFAQRVDAVLIAEGVETWNELAVLLRLGIRHAQGYLLARPVSSPQRPGADFAERCREAIRALHHREHEDDETVGSMIIRPPCAPVTAQAVELDRLFRRTPGEDHVVLLDGEQPQAVVTRRNFYARFGGTAASTEAALPDEPREAPMVVEDATAITALARMAMRRPPETVYDPVVVTDAKGHFLGTVTMKQLIARASDLEQHAATGAHPLTDLPGSRMIERWIRAALQGSAFTVIYADLDHFEAYNDRYGFLQGDRVIRYTASVLSECLHLLPEGSNLGHVGGDDFVLVCPDAVAPEVLRTLCQRFDAEKVPLYGPEDLRRGGFTAKDAAGNTVPVTLSLAAVDHQGLSANPHPAELSAVAASLRKRVKAVSAQTHTSTFLFQPGAVK
>NC_017030.1|WP_014398345.1|6983628_6984105_+|Cys-tRNA(Pro)-deacylase
MKTNAARLLDSLGIAYSLRDYDVDPDDLSAETVAAKVGMPAEQVFKTLVAKGDRTGVLMAVVPGNAELDLKALARLSGDRKVDTVPLKELQPLTGYIRGGVTALGGKKDYPVFVDETLELFDEVAVSAGVRGTQIVLAPADYLRVTKGKPGPISRPKA
>NC_017030.1|WP_014398344.1|6982480_6983623_+|5-(carboxyamino)imidazole-ribonucleotide-synthase
MSGPMVLPGGTLGILGGGQLGRMMALAARTLGYQVQALDPDSACPSRSVVDRCLTASFTDTAAAEDLARQCDVVTLEIEKVSLSTLNAVARHAPMRPGASVLEVVQHRGRQKAWLAKGGFPLGPWREANSEAELSQAITALGGKCFIKSSEGGYDGRGQYEVKTASEAGVAWKELGERSVVVEAALDLKAELSVLVARGPDGQLAVYPPAFNHHEERILAWSLLPGPLPQAVLTQASQVARDITAGLKVEGLLVVEMFLLGDGSLLVNEVAPRPHNSFHSTEVACLTSQFEQAVRAVCNLPLGSVEVVRPAAIVNLLGDLWLQEGGPRFAQALALPGVRLHLYGKRDARKGRKMGHLSAVGSTPEDALQRVKAAATALGM
>NC_017030.1|WP_014398343.1|6981980_6982484_+|5-(carboxyamino)imidazole-ribonucleotide-mutase
MAASASTPWVGVIMGGKSDLEHLQPAIDILAELRIPHEVRVVSAHRTPDWMMEYASSAEGRGLSVIIAAAGGAAHLPGMVSSKTLLPVLGVPMPTTVLSGFDALLSIVQMPKGVPVGTQAIGKPGAANAALHAAAILALKYPELRERLAAWRKARTDEVLAQREVAG
>NC_017030.1|WP_014398342.1|6980391_6981816_+|VWA-domain-containing-protein
MNRTVLFLALAGGLALTALVLGMPRGGGLPPTPHVVVTPPPPVTPPGPRASTGSLQVTSRLSHPYVPVGPSETYVTVDLTGAEVPGAKRSPVNLAVVIDRSGSMSGYKLQQAKQAARHLVTLLRDEDRLAIVHYGSDVKSLPSLPATAGNRERMLQFIDGIWDDGGTNISAGLSVGRTQLASAMGGTATVNRLILMSDGQPTEGVSDEEGLKNVVREIRASGITVSSIGVGTDFNEDLMQAFAEYGAGAYGFLEDASKLSTLFQRDLQQATTAVARNVELSFELPPGTSLGEVLGYRAHQAGNTVRVALPDFSAGQVERVVARLHVTGTAPGQSVQVAGLKVAYTDLLVQKNVEDQSTLAAVATHVQEEIVQRQDKEATVYAARARSAQNLQKAAEAMSQGKKAEAKGYLSQNQALFEEAGAVAGAAAVAADQAEQSRAMQEYDDADSYEAQKAAVKNSKVKALKSFGRMGSTY
>NC_017030.1|WP_014398341.1|6979782_6980289_+|adventurous-gliding-motility-lipoprotein-CglC
MFVRTALFLSAALMLGGCDVTTELGKPCQLVRRATAEEQAAQGRKFMEIQEKDIAVDQDFISFGSLDCEDLVCVRDDLSPRSDNPEAFALGYCSKECVQGTTTGCEITRTVGDVEEGLKERMTCRPLLLDQDTLDAIKIADEGFYRRTFGENNSPYFCAGAVSASQGT
>NC_017030.1|WP_043323830.1|6978683_6979511_-|outer-membrane-beta-barrel-domain-containing-protein
MNRPTLLLALSLMWPALAPAQNQPGMGLDLTEDAQAKPPEENPAPPPDEEARPASPPAATPAKEIPVEALMPLTDITQDDRVKSVQRKVYLKKNRLEISPFVSLSVNDPFYSKFGGSLRAAWYLSDTLAISARGSLIQVIPSDDVSTAKRTFNSKIYASVPNWSAMGDLEWAPLYGKVSFLNSILHFDGYLLGGMGVVRTETSALPDRGLNPAFDLGLGMRFVTKDYLAVNVALINTSYVDQPLGSSKGALQNVMTLNAGISIFLPLKSTGRESE
>NC_017030.1|WP_014398339.1|6977790_6978687_-|outer-membrane-beta-barrel-domain-containing-protein
MKPAFRLLLTLCAGVPALAAADQAPAPAPAAAAPAAPATPAPAPAAAAPKTAANSNPPSTSQEEEAGDVSEVDKDALGPLRERIRPVSGHMFLKKGRFEVSPSASITIRDAFFKKYLFGGTVTYFPMETLGVGLRGGYALNSVAGSAQKCTFTPGEGGDTRGCSAPTREELDGYAPGQMTLMGGVDVQWAPIYGKLSLLAEKFVHFDMYGVVGATVVQYKGPAESLSDGTPVAGSKSYLTGGGNVGVGLRFFFNRWMTLRTELRDIIYVEKGRDPTPNYLRNQILFELGLSFFFPSGS
>NC_017030.1|WP_014398338.1|6975733_6977785_-|adventurous-gliding-motility-protein-GltC
MRTHRFLRLAVLGLTLAYTAPTLAQSFEGLDLAGQSKKKKKGASSKASSKKKTSAKRGKGKATAPAEEVDESSTATSEPAPAGNPATPPAAVTTTPAPSAMPAAPAAKPTPPAKPAAQGSPGLGLDLTGDNDKPPAPTMTFDAVDVSGKTADRQRLDAAISLFKNDEYEKAAMASHELLGDPKLQGLHVEARYVLAKSLYRMGLYHSSLGEFSKILAAGPSTKFFKTSLEWLFFISRKTQNETVILDEIARYANYEFPEKFRNEFRYLLARYHFVRGRALDQVGQTENADKSFEEVKRLALTIPRTDAFYPRAKYLEGLAFFRNGTRNKDAASKRGNTDVLASVEAMKEVVRLTRPMAGRTGEAAKLDKSLRELAFMQLARTHYGMQQNRFSIFYLNKVERGNTQWLEALFESSWANYRIGQYEQALGNLITLSSPFFREEYFPEALILKAVIYYENCRYRESNLILQDFERTYLPVHDELDGLVKKNMEASEYYTVLADVQKKNKDGLEKNGTDVILERILRLALTDQDLKKTNDSILELEGEMDLFSNKGDTFKYSELTKQLLEELKVQRTSLISKAGIMAKGKLESELGALKLLLANGLRIKFETTTKEKEFLEEQLKAGGRTAIVKKYKFSVAVADDQLYWPYEGEYWRDELGTYQYTMTKGCIERDTANRQMQSAEAM
>NC_017030.1|WP_014398337.1|6974311_6975622_-|MFS-transporter
MAREASLRVVFGIAVLDLIGFGILIPQLGVYGVRFGASPFAVGLLVAVYSLMQLVAAPIMGRLSDRFGRRPVLLISQVGSLLGYVLFAFAHTLPLLFLSRVIDGVSGGNVSTAQAVVADITKPHERARGMGIIGAAFGLGFVLGPALGGVLGAWGGNLAIGLFAAGLSALNLINTWFFLPETRRADSPSATTRSMRGAAAVLTLPVVGRCVVLVLLYTVAFAQMEGTFSVYLLTRFLSSGPVPLEGGWLVHAVHPDAAVLKEASLRSGALFAVVGVLSALVQGGLVRRLVAAHGAPGQGAEGAPGGRGGREAPVAVVGFGLTAAGLALLPVAPSYGWLFPVMGLLAVGSALVTPCLSALVSLHAPMERQGAVLGAYQASGSLGRIIGPALGGLLFTRLGPTAPYGTGAVLVALGGLLALSLVTQVRMSGAGAEQSS
>NC_017030.1|WP_014398348.1|6988195_6988954_-|hypothetical-protein
MRYVEPDAPALLSTRLKEPRYSRKDEEPADDRVRNFYAEEQEKKRRGRLPAFPCTPELGLNNEFGWRLQGFIEDAKGRLRIQTLEERVYCMGCHTNLGVTGDQTFAFPRKVQGRDGWRKQDLRGLPDVPQAGHAAPETATYFECVQGGDEFRANEELLARFFPNGVLDLPAVRRAAPGGDRDLAWLVTPSRERALQLDKAYQALVRKQAFARGRDTLLVPPANVHRAVENGSTELETTGRLYTDGRLHLAWE
>NC_017030.1|WP_148282362.1|6988987_6989323_-|hypothetical-protein
MRYQPFLGTFWPTNGGTDDVYVWLPESFRKDAHGQLSREVYRFNLEVLDAAMTVDPDLLDVKGASRRVDPVDARVGGLDLDGDGVLSPSVERVRGLPTHDAGSAADMRVRR
>NC_017030.1|WP_014398350.1|6989431_6989983_-|DUF192-domain-containing-protein
MKARFTFILAALAFAGGACQEAPAAPPKPAAPAPARPRSKDVSAEDYVMPTLPRAHVRLKDAYGGVRRVEVEVAATGESRTRGLMWRKSLPAGQGMLFIFPDEEVRGFWMRNTLIPLDMLFITSEGRVVGIIENAEPRTLTNRTVGIPSQYVLEVPGGWCQKNGIVRGGTAEFEGVSTLPITP
>NC_017030.1|WP_043321926.1|6989979_6990381_-|TIGR02266-family-protein
MSEQKSGSELRTHGRAPIELKVDYKKLNSFFADYTKNISKGGTFIKTKKPLPIGTRFLFKLTVPHREAPFELLGEVVWSKADAEEPGMGIRFIYSSESQRVDFETLVERLMSDSLGSELTEKLLNKPLHPQHP
>NC_017030.1|WP_193352512.1|6990406_6992770_+|hypothetical-protein
MRQVLPRARALLGRPAVLATVLLLGGGGSALVLLPLFGVPGFELGLALSIAVGLLGGGTGIAAAAQERRILTGAAPLPARVEASALPGTAVGRALGASAVLNLGVLVPPFVCALLFARLRTACDPFELAGFYPLLTIPSALVASAAGVLLGFATARPRGAAGLYALLLLASLAVTVWPIVFGPQVFAFNIFLGHLPGPLYDEALQMTAALGWFRLETLLWVGVFAGLAIALLDVRTGRLALKGARLGGLLGLVLPCALGILWLEARAPQLGLRMSDAYLSEQLGGVRETDHFVLHYPRGKARQDVDRMARDLEFRFTQTSGFLGVAPTERVRVWLYRSEDEKQRLVGAGRTQYAKPWRTELHIQDKPFPHSTLHHELAHVMAGPAGSGFFRVTTRLGVWPLMGVIEGLAVAADDPVQGELTLHQWAAGMRRQGLAPDMRDLMGPKGFYQSAPARAYTVAGSFLRYLADTYGADRLRAVYAHADFNEAYGRPLDELVTEWERTLDALPLDASALARAFARFRTGSLFTRACAREVARLSDSARESLASDPQDALDRYQRAARLQPEEPSYQLGQAVALDALERGPDAAKVLAALADQVKDRPALAAEVAVARADVALHLEDVEGSRAFLQAALALDPGPELTRTAQVKLAALETPSRRGPIEAYFRAPQEELRLLLLDRALLAAPMDPWLHYLLGRRLHQVGAPALAGDQLQRALSDTTLPEAIRREATRLRIEAAYLAGDCGAVRHEVGALPDYGAAFRAAASEWQARCDFEQTAYRGPLVPRQAFR
>NC_017030.1|WP_014398353.1|6992824_6993352_+|hypothetical-protein
MHFEKTQYIQGTVDEVERALLDERYFPFLLQHHGVLLELQPQEVRVDGDRVHRKVRYRPKPVISSVGPKKVSPEWFAFIETSTYDKRTKQLTFTNTPTSHTISKMLVNTGVLKLRDLGNGQTERKMEGELSLKVPFLLKPVAMIAEPLIKTEGLKILDGELPVLNRFIAEVIRAK
>NC_017030.1|WP_014398354.1|6993425_6993899_+|nuclear-transport-factor-2-family-protein
MHKRFLALCAVFLLAACAPKRIPGTELEDTGDTRAILAVMEKYRSALENRDAKAIQALVSPKFRDDAGTPDDPTDDLNASNLEAHLQGLFTKLQNPKVDFNIRRVEFHEDEDVALAIYYWNASWRMPGLNARPQSDSELEQMVFQKVDGDWKIVSGI
>NC_017030.1|WP_014398355.1|6993914_6994883_-|homoserine-kinase
MAVYTTLPPEAFTQVADVWGLGAVRSITPIPQGSINTNHRLETDSGRVFVRHTTVRSPEDLRFEASLLDHLSRAHFPAPVLLVPPGPSPFLELHGGRISVFKWLAGEEYTRDRLTPEVLERLGAELGKLHRVTQSFGGTRANPYGPGLVKGWLEGLSRRPEPELVSVAAELERYLARVEAERQGLEPRGVIHADLFLDNVKWLGDRVGAFFDFEMACVDAYALDVAITLNAWCFEGSYQPERCQALLRGYQDARPLSDVEKRALYGHALYGAVRFTTSRIRDYHLSPLGADKLAPKDFRTYLSRARALNDMGPDGLRALVGA
>NC_017030.1|WP_014398356.1|6995027_6996638_+|tetratricopeptide-repeat-protein
METSGRGDWKRREGLGSALAQIGVVAVLLAAGVAWYVHRGQVRQEVDAHLRTARSAVLKGNPSDLAMAQQNLEALFALAPDSRDARALAADLQAELWLTHHQPGADAKAREQLERAETLGSRSGERYGARALLLVGAGQTAEANKLLEELKSQGASSPRLTLAQARLLQKEGRLSEARQAFARAAEGAWKDPRFSAAYGEALLDEGMFPQAVEAFARATTANPDHLLSRVTSALAQLYAGRPPDGVTALLEEVRSRGKELTPALQARMAVAQAEVSLAKGAPDEALTHVDAALKAWPEEHYALFTRGRALAVKRAPEARQAFEAAAAKRPTAPLLTLEGARLLQAQGDGEGALAMLDAYEKTFREVKTRTADGKELPALDRDDRYWLARGGVMEAAGRQDDALAAYDKALAARGVGLARAQYAKGALLLARKDFDGAKSLLTAVAPETGAGSMPEAYAALGELLFAQGEFAAGCQQHYFSLVRARAQGAPVEQLATRANDIKKRLETSGQPAMAKAWLTEAGPLFNGGNEPAAVTR
>NC_017030.1|WP_014398357.1|6996634_6997126_-|hypothetical-protein
MVLTRTRVLSGMAAVVAAALVLFFWPREEPGVKDAVTRRIIAMTSAAEEKDVGEVMEGVSERFKTTEGWSKQEVRSILTAQVLRGQWVRIFTTDIDVHEVSPTQGDFQARFIFGRSQADKLEDLARDSVLNAYSIEGTFEKEADGEWRVVKAKQRRLDPSELL

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Crispr_ID: NC_017030_27

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_27

6987646-6987744

Orphan

Consensus_repeat	Method
AAACCTGTCCGACTGTCCGACAGGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_27

>merge|NC_017030|27|6987646-6987744|CRISPRCasFinder
AAACCTGTCCGACTGTCCGACAGGTTTGGAGGCCCCAGGGCCAGAGAGGCTGCCGGTCCATCCACGCGGCCAAAACCTGTCCGACTGTCCGACAGGTTA

>NC_017030|27|22|6987646-6987744|CRISPRCasFinder
AAACCTGTCCGACTGTCCGACAGGTT	TGGAGGCCCCAGGGCCAGAGAGGCTGCCGGTCCATCCACGCGGCCA
AAACCTGTCCGACTGTCCGACAGGTTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014398355.1\|6993914_6994883_-\|homoserine-kinase	unknown	unknown	gnl\|CDD\|270702
NC_017030.1\|WP_014398357.1\|6996634_6997126_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398342.1\|6980391_6981816_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238742
NC_017030.1\|WP_014398345.1\|6983628_6984105_+\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NC_017030.1\|WP_014398339.1\|6977790_6978687_-\|outer-membrane-beta-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|275358
NC_017030.1\|WP_014398356.1\|6995027_6996638_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_017030.1\|WP_193352512.1\|6990406_6992770_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276808
NC_017030.1\|WP_014398347.1\|6985546_6987325_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225110
NC_017030.1\|WP_014398353.1\|6992824_6993352_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_148282362.1\|6988987_6989323_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398338.1\|6975733_6977785_-\|adventurous-gliding-motility-protein-GltC	unknown	unknown	gnl\|CDD\|236776
NC_017030.1\|WP_014398343.1\|6981980_6982484_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl\|CDD\|376377
NC_017030.1\|WP_014398341.1\|6979782_6980289_+\|adventurous-gliding-motility-lipoprotein-CglC	unknown	unknown	unknown
NC_017030.1\|WP_014398348.1\|6988195_6988954_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398344.1\|6982480_6983623_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
NC_017030.1\|WP_014398337.1\|6974311_6975622_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340888
NC_017030.1\|WP_043323830.1\|6978683_6979511_-\|outer-membrane-beta-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|275358
NC_017030.1\|WP_014398354.1\|6993425_6993899_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379639
NC_017030.1\|WP_014398350.1\|6989431_6989983_-\|DUF192-domain-containing-protein	unknown	unknown	gnl\|CDD\|376876
NC_017030.1\|WP_043321926.1\|6989979_6990381_-\|TIGR02266-family-protein	unknown	unknown	gnl\|CDD\|274060

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014398355.1\|6993914_6994883_-\|homoserine-kinase	gnl\|CDD\|270702	cd05153, HomoserineK_II, Type II Homoserine Kinase. This subfamily is composed of unusual homoserine kinases, from a subset of bacteria, which have a Protein Kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	6.36059e-78
NC_017030.1\|WP_014398342.1\|6980391_6981816_+\|VWA-domain-containing-protein	gnl\|CDD\|238742	cd01465, vWA_subgroup, VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known.	3.30124e-40
NC_017030.1\|WP_014398345.1\|6983628_6984105_+\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	2.12192e-68
NC_017030.1\|WP_014398339.1\|6977790_6978687_-\|outer-membrane-beta-barrel-domain-containing-protein	gnl\|CDD\|275358	TIGR04565, hypothetical_protein_N47_G32130, outer membrane beta-barrel protein. Members of this family are outer membrane beta-barrel proteins, as inferred by distant homologies to other families (e.g. pfam13505) and by the concentration of aromatic residues, especially Phe, in the OMP signal region, which is flush with the C-terminus in some members, but followed by a few residues in others. Members have variable insertions and deletions, affecting scores, so this model does not cleanly separate all members from all non-members. Members are common in the Myxococcales, with five occurring in Myxococcus xanthus DK 1622.	3.35457e-44
NC_017030.1\|WP_014398356.1\|6995027_6996638_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	9.5294e-07
NC_017030.1\|WP_193352512.1\|6990406_6992770_+\|hypothetical-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	0.00145237
NC_017030.1\|WP_014398347.1\|6985546_6987325_+\|GGDEF-domain-containing-protein	gnl\|CDD\|225110	COG2200, Rtn, c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms].	3.20806e-62
NC_017030.1\|WP_014398354.1\|6993425_6993899_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	1.27231e-08
NC_017030.1\|WP_014398338.1\|6975733_6977785_-\|adventurous-gliding-motility-protein-GltC	gnl\|CDD\|236776	PRK10856, PRK10856, cytoskeleton protein RodZ.	5.19244e-07
NC_017030.1\|WP_014398343.1\|6981980_6982484_+\|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl\|CDD\|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	6.16241e-81
NC_017030.1\|WP_014398344.1\|6982480_6983623_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	8.41634e-154
NC_017030.1\|WP_014398337.1\|6974311_6975622_-\|MFS-transporter	gnl\|CDD\|340888	cd17330, MFS_SLC46_TetA_like, Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.46884e-73
NC_017030.1\|WP_043323830.1\|6978683_6979511_-\|outer-membrane-beta-barrel-domain-containing-protein	gnl\|CDD\|275358	TIGR04565, hypothetical_protein_N47_G32130, outer membrane beta-barrel protein. Members of this family are outer membrane beta-barrel proteins, as inferred by distant homologies to other families (e.g. pfam13505) and by the concentration of aromatic residues, especially Phe, in the OMP signal region, which is flush with the C-terminus in some members, but followed by a few residues in others. Members have variable insertions and deletions, affecting scores, so this model does not cleanly separate all members from all non-members. Members are common in the Myxococcales, with five occurring in Myxococcus xanthus DK 1622.	1.21428e-35
NC_017030.1\|WP_014398350.1\|6989431_6989983_-\|DUF192-domain-containing-protein	gnl\|CDD\|376876	pfam02643, DUF192, Uncharacterized ACR, COG1430. Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for Structure 3pjy shows that there is much similarity with the other solved structure, Structure 3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. Structure 3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).	5.45096e-48
NC_017030.1\|WP_043321926.1\|6989979_6990381_-\|TIGR02266-family-protein	gnl\|CDD\|274060	TIGR02266, gmx_TIGR02266, Myxococcus xanthus paralogous domain TIGR02266. This domain is related to Type IV pilus assembly protein PilZ (pfam07238). It is found in at least 12 copies in Myxococcus xanthus DK 1622.	5.53966e-36

>NC_017030.1|WP_014398347.1|6985546_6987325_+|GGDEF-domain-containing-protein
MSLPSPSKPAPPPPWLWNGDEPRVATVFQPIVDLLSGEVLGHEVLSRGLGPVESPNELFNRARVEGFTYELERACWTAAVRRIATLPEAQRRGPFFFNVSPDVLSDERFGGASTLELLRQHGLSPQQLVLEITERSTFEDTEQLRMLARRYAEQGFGIALDDFGAGHSGLVTLVHSAPDFIKLDQALVRDIHLHTYRQHLVKSLVAFAQRVDAVLIAEGVETWNELAVLLRLGIRHAQGYLLARPVSSPQRPGADFAERCREAIRALHHREHEDDETVGSMIIRPPCAPVTAQAVELDRLFRRTPGEDHVVLLDGEQPQAVVTRRNFYARFGGTAASTEAALPDEPREAPMVVEDATAITALARMAMRRPPETVYDPVVVTDAKGHFLGTVTMKQLIARASDLEQHAATGAHPLTDLPGSRMIERWIRAALQGSAFTVIYADLDHFEAYNDRYGFLQGDRVIRYTASVLSECLHLLPEGSNLGHVGGDDFVLVCPDAVAPEVLRTLCQRFDAEKVPLYGPEDLRRGGFTAKDAAGNTVPVTLSLAAVDHQGLSANPHPAELSAVAASLRKRVKAVSAQTHTSTFLFQPGAVK
>NC_017030.1|WP_014398345.1|6983628_6984105_+|Cys-tRNA(Pro)-deacylase
MKTNAARLLDSLGIAYSLRDYDVDPDDLSAETVAAKVGMPAEQVFKTLVAKGDRTGVLMAVVPGNAELDLKALARLSGDRKVDTVPLKELQPLTGYIRGGVTALGGKKDYPVFVDETLELFDEVAVSAGVRGTQIVLAPADYLRVTKGKPGPISRPKA
>NC_017030.1|WP_014398344.1|6982480_6983623_+|5-(carboxyamino)imidazole-ribonucleotide-synthase
MSGPMVLPGGTLGILGGGQLGRMMALAARTLGYQVQALDPDSACPSRSVVDRCLTASFTDTAAAEDLARQCDVVTLEIEKVSLSTLNAVARHAPMRPGASVLEVVQHRGRQKAWLAKGGFPLGPWREANSEAELSQAITALGGKCFIKSSEGGYDGRGQYEVKTASEAGVAWKELGERSVVVEAALDLKAELSVLVARGPDGQLAVYPPAFNHHEERILAWSLLPGPLPQAVLTQASQVARDITAGLKVEGLLVVEMFLLGDGSLLVNEVAPRPHNSFHSTEVACLTSQFEQAVRAVCNLPLGSVEVVRPAAIVNLLGDLWLQEGGPRFAQALALPGVRLHLYGKRDARKGRKMGHLSAVGSTPEDALQRVKAAATALGM
>NC_017030.1|WP_014398343.1|6981980_6982484_+|5-(carboxyamino)imidazole-ribonucleotide-mutase
MAASASTPWVGVIMGGKSDLEHLQPAIDILAELRIPHEVRVVSAHRTPDWMMEYASSAEGRGLSVIIAAAGGAAHLPGMVSSKTLLPVLGVPMPTTVLSGFDALLSIVQMPKGVPVGTQAIGKPGAANAALHAAAILALKYPELRERLAAWRKARTDEVLAQREVAG
>NC_017030.1|WP_014398342.1|6980391_6981816_+|VWA-domain-containing-protein
MNRTVLFLALAGGLALTALVLGMPRGGGLPPTPHVVVTPPPPVTPPGPRASTGSLQVTSRLSHPYVPVGPSETYVTVDLTGAEVPGAKRSPVNLAVVIDRSGSMSGYKLQQAKQAARHLVTLLRDEDRLAIVHYGSDVKSLPSLPATAGNRERMLQFIDGIWDDGGTNISAGLSVGRTQLASAMGGTATVNRLILMSDGQPTEGVSDEEGLKNVVREIRASGITVSSIGVGTDFNEDLMQAFAEYGAGAYGFLEDASKLSTLFQRDLQQATTAVARNVELSFELPPGTSLGEVLGYRAHQAGNTVRVALPDFSAGQVERVVARLHVTGTAPGQSVQVAGLKVAYTDLLVQKNVEDQSTLAAVATHVQEEIVQRQDKEATVYAARARSAQNLQKAAEAMSQGKKAEAKGYLSQNQALFEEAGAVAGAAAVAADQAEQSRAMQEYDDADSYEAQKAAVKNSKVKALKSFGRMGSTY
>NC_017030.1|WP_014398341.1|6979782_6980289_+|adventurous-gliding-motility-lipoprotein-CglC
MFVRTALFLSAALMLGGCDVTTELGKPCQLVRRATAEEQAAQGRKFMEIQEKDIAVDQDFISFGSLDCEDLVCVRDDLSPRSDNPEAFALGYCSKECVQGTTTGCEITRTVGDVEEGLKERMTCRPLLLDQDTLDAIKIADEGFYRRTFGENNSPYFCAGAVSASQGT
>NC_017030.1|WP_043323830.1|6978683_6979511_-|outer-membrane-beta-barrel-domain-containing-protein
MNRPTLLLALSLMWPALAPAQNQPGMGLDLTEDAQAKPPEENPAPPPDEEARPASPPAATPAKEIPVEALMPLTDITQDDRVKSVQRKVYLKKNRLEISPFVSLSVNDPFYSKFGGSLRAAWYLSDTLAISARGSLIQVIPSDDVSTAKRTFNSKIYASVPNWSAMGDLEWAPLYGKVSFLNSILHFDGYLLGGMGVVRTETSALPDRGLNPAFDLGLGMRFVTKDYLAVNVALINTSYVDQPLGSSKGALQNVMTLNAGISIFLPLKSTGRESE
>NC_017030.1|WP_014398339.1|6977790_6978687_-|outer-membrane-beta-barrel-domain-containing-protein
MKPAFRLLLTLCAGVPALAAADQAPAPAPAAAAPAAPATPAPAPAAAAPKTAANSNPPSTSQEEEAGDVSEVDKDALGPLRERIRPVSGHMFLKKGRFEVSPSASITIRDAFFKKYLFGGTVTYFPMETLGVGLRGGYALNSVAGSAQKCTFTPGEGGDTRGCSAPTREELDGYAPGQMTLMGGVDVQWAPIYGKLSLLAEKFVHFDMYGVVGATVVQYKGPAESLSDGTPVAGSKSYLTGGGNVGVGLRFFFNRWMTLRTELRDIIYVEKGRDPTPNYLRNQILFELGLSFFFPSGS
>NC_017030.1|WP_014398338.1|6975733_6977785_-|adventurous-gliding-motility-protein-GltC
MRTHRFLRLAVLGLTLAYTAPTLAQSFEGLDLAGQSKKKKKGASSKASSKKKTSAKRGKGKATAPAEEVDESSTATSEPAPAGNPATPPAAVTTTPAPSAMPAAPAAKPTPPAKPAAQGSPGLGLDLTGDNDKPPAPTMTFDAVDVSGKTADRQRLDAAISLFKNDEYEKAAMASHELLGDPKLQGLHVEARYVLAKSLYRMGLYHSSLGEFSKILAAGPSTKFFKTSLEWLFFISRKTQNETVILDEIARYANYEFPEKFRNEFRYLLARYHFVRGRALDQVGQTENADKSFEEVKRLALTIPRTDAFYPRAKYLEGLAFFRNGTRNKDAASKRGNTDVLASVEAMKEVVRLTRPMAGRTGEAAKLDKSLRELAFMQLARTHYGMQQNRFSIFYLNKVERGNTQWLEALFESSWANYRIGQYEQALGNLITLSSPFFREEYFPEALILKAVIYYENCRYRESNLILQDFERTYLPVHDELDGLVKKNMEASEYYTVLADVQKKNKDGLEKNGTDVILERILRLALTDQDLKKTNDSILELEGEMDLFSNKGDTFKYSELTKQLLEELKVQRTSLISKAGIMAKGKLESELGALKLLLANGLRIKFETTTKEKEFLEEQLKAGGRTAIVKKYKFSVAVADDQLYWPYEGEYWRDELGTYQYTMTKGCIERDTANRQMQSAEAM
>NC_017030.1|WP_014398337.1|6974311_6975622_-|MFS-transporter
MAREASLRVVFGIAVLDLIGFGILIPQLGVYGVRFGASPFAVGLLVAVYSLMQLVAAPIMGRLSDRFGRRPVLLISQVGSLLGYVLFAFAHTLPLLFLSRVIDGVSGGNVSTAQAVVADITKPHERARGMGIIGAAFGLGFVLGPALGGVLGAWGGNLAIGLFAAGLSALNLINTWFFLPETRRADSPSATTRSMRGAAAVLTLPVVGRCVVLVLLYTVAFAQMEGTFSVYLLTRFLSSGPVPLEGGWLVHAVHPDAAVLKEASLRSGALFAVVGVLSALVQGGLVRRLVAAHGAPGQGAEGAPGGRGGREAPVAVVGFGLTAAGLALLPVAPSYGWLFPVMGLLAVGSALVTPCLSALVSLHAPMERQGAVLGAYQASGSLGRIIGPALGGLLFTRLGPTAPYGTGAVLVALGGLLALSLVTQVRMSGAGAEQSS
>NC_017030.1|WP_014398348.1|6988195_6988954_-|hypothetical-protein
MRYVEPDAPALLSTRLKEPRYSRKDEEPADDRVRNFYAEEQEKKRRGRLPAFPCTPELGLNNEFGWRLQGFIEDAKGRLRIQTLEERVYCMGCHTNLGVTGDQTFAFPRKVQGRDGWRKQDLRGLPDVPQAGHAAPETATYFECVQGGDEFRANEELLARFFPNGVLDLPAVRRAAPGGDRDLAWLVTPSRERALQLDKAYQALVRKQAFARGRDTLLVPPANVHRAVENGSTELETTGRLYTDGRLHLAWE
>NC_017030.1|WP_148282362.1|6988987_6989323_-|hypothetical-protein
MRYQPFLGTFWPTNGGTDDVYVWLPESFRKDAHGQLSREVYRFNLEVLDAAMTVDPDLLDVKGASRRVDPVDARVGGLDLDGDGVLSPSVERVRGLPTHDAGSAADMRVRR
>NC_017030.1|WP_014398350.1|6989431_6989983_-|DUF192-domain-containing-protein
MKARFTFILAALAFAGGACQEAPAAPPKPAAPAPARPRSKDVSAEDYVMPTLPRAHVRLKDAYGGVRRVEVEVAATGESRTRGLMWRKSLPAGQGMLFIFPDEEVRGFWMRNTLIPLDMLFITSEGRVVGIIENAEPRTLTNRTVGIPSQYVLEVPGGWCQKNGIVRGGTAEFEGVSTLPITP
>NC_017030.1|WP_043321926.1|6989979_6990381_-|TIGR02266-family-protein
MSEQKSGSELRTHGRAPIELKVDYKKLNSFFADYTKNISKGGTFIKTKKPLPIGTRFLFKLTVPHREAPFELLGEVVWSKADAEEPGMGIRFIYSSESQRVDFETLVERLMSDSLGSELTEKLLNKPLHPQHP
>NC_017030.1|WP_193352512.1|6990406_6992770_+|hypothetical-protein
MRQVLPRARALLGRPAVLATVLLLGGGGSALVLLPLFGVPGFELGLALSIAVGLLGGGTGIAAAAQERRILTGAAPLPARVEASALPGTAVGRALGASAVLNLGVLVPPFVCALLFARLRTACDPFELAGFYPLLTIPSALVASAAGVLLGFATARPRGAAGLYALLLLASLAVTVWPIVFGPQVFAFNIFLGHLPGPLYDEALQMTAALGWFRLETLLWVGVFAGLAIALLDVRTGRLALKGARLGGLLGLVLPCALGILWLEARAPQLGLRMSDAYLSEQLGGVRETDHFVLHYPRGKARQDVDRMARDLEFRFTQTSGFLGVAPTERVRVWLYRSEDEKQRLVGAGRTQYAKPWRTELHIQDKPFPHSTLHHELAHVMAGPAGSGFFRVTTRLGVWPLMGVIEGLAVAADDPVQGELTLHQWAAGMRRQGLAPDMRDLMGPKGFYQSAPARAYTVAGSFLRYLADTYGADRLRAVYAHADFNEAYGRPLDELVTEWERTLDALPLDASALARAFARFRTGSLFTRACAREVARLSDSARESLASDPQDALDRYQRAARLQPEEPSYQLGQAVALDALERGPDAAKVLAALADQVKDRPALAAEVAVARADVALHLEDVEGSRAFLQAALALDPGPELTRTAQVKLAALETPSRRGPIEAYFRAPQEELRLLLLDRALLAAPMDPWLHYLLGRRLHQVGAPALAGDQLQRALSDTTLPEAIRREATRLRIEAAYLAGDCGAVRHEVGALPDYGAAFRAAASEWQARCDFEQTAYRGPLVPRQAFR
>NC_017030.1|WP_014398353.1|6992824_6993352_+|hypothetical-protein
MHFEKTQYIQGTVDEVERALLDERYFPFLLQHHGVLLELQPQEVRVDGDRVHRKVRYRPKPVISSVGPKKVSPEWFAFIETSTYDKRTKQLTFTNTPTSHTISKMLVNTGVLKLRDLGNGQTERKMEGELSLKVPFLLKPVAMIAEPLIKTEGLKILDGELPVLNRFIAEVIRAK
>NC_017030.1|WP_014398354.1|6993425_6993899_+|nuclear-transport-factor-2-family-protein
MHKRFLALCAVFLLAACAPKRIPGTELEDTGDTRAILAVMEKYRSALENRDAKAIQALVSPKFRDDAGTPDDPTDDLNASNLEAHLQGLFTKLQNPKVDFNIRRVEFHEDEDVALAIYYWNASWRMPGLNARPQSDSELEQMVFQKVDGDWKIVSGI
>NC_017030.1|WP_014398355.1|6993914_6994883_-|homoserine-kinase
MAVYTTLPPEAFTQVADVWGLGAVRSITPIPQGSINTNHRLETDSGRVFVRHTTVRSPEDLRFEASLLDHLSRAHFPAPVLLVPPGPSPFLELHGGRISVFKWLAGEEYTRDRLTPEVLERLGAELGKLHRVTQSFGGTRANPYGPGLVKGWLEGLSRRPEPELVSVAAELERYLARVEAERQGLEPRGVIHADLFLDNVKWLGDRVGAFFDFEMACVDAYALDVAITLNAWCFEGSYQPERCQALLRGYQDARPLSDVEKRALYGHALYGAVRFTTSRIRDYHLSPLGADKLAPKDFRTYLSRARALNDMGPDGLRALVGA
>NC_017030.1|WP_014398356.1|6995027_6996638_+|tetratricopeptide-repeat-protein
METSGRGDWKRREGLGSALAQIGVVAVLLAAGVAWYVHRGQVRQEVDAHLRTARSAVLKGNPSDLAMAQQNLEALFALAPDSRDARALAADLQAELWLTHHQPGADAKAREQLERAETLGSRSGERYGARALLLVGAGQTAEANKLLEELKSQGASSPRLTLAQARLLQKEGRLSEARQAFARAAEGAWKDPRFSAAYGEALLDEGMFPQAVEAFARATTANPDHLLSRVTSALAQLYAGRPPDGVTALLEEVRSRGKELTPALQARMAVAQAEVSLAKGAPDEALTHVDAALKAWPEEHYALFTRGRALAVKRAPEARQAFEAAAAKRPTAPLLTLEGARLLQAQGDGEGALAMLDAYEKTFREVKTRTADGKELPALDRDDRYWLARGGVMEAAGRQDDALAAYDKALAARGVGLARAQYAKGALLLARKDFDGAKSLLTAVAPETGAGSMPEAYAALGELLFAQGEFAAGCQQHYFSLVRARAQGAPVEQLATRANDIKKRLETSGQPAMAKAWLTEAGPLFNGGNEPAAVTR
>NC_017030.1|WP_014398357.1|6996634_6997126_-|hypothetical-protein
MVLTRTRVLSGMAAVVAAALVLFFWPREEPGVKDAVTRRIIAMTSAAEEKDVGEVMEGVSERFKTTEGWSKQEVRSILTAQVLRGQWVRIFTTDIDVHEVSPTQGDFQARFIFGRSQADKLEDLARDSVLNAYSIEGTFEKEADGEWRVVKAKQRRLDPSELL

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Crispr_ID: NC_017030_29

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_29

7245091-7245204

Orphan

Consensus_repeat	Method
CCGCAGCAGGGCGGGCCGCGCAACGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_29

>merge|NC_017030|29|7245091-7245204|CRISPRCasFinder
CCGCAGCAGGGCGGGCCGCGCAACGGCGCTCCGGCGCAGGGCGCGACTGCTCCGGTGGCGCAGGGCGATGCGCGCATGAACGGCCGGCCGCAGCAGGGCGGGCCGCGCAACGGC

>NC_017030|29|24|7245091-7245204|CRISPRCasFinder
CCGCAGCAGGGCGGGCCGCGCAACGGC	GCTCCGGCGCAGGGCGCGACTGCTCCGGTGGCGCAGGGCGATGCGCGCATGAACGGCCGG
CCGCAGCAGGGCGGGCCGCGCAACGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014398537.1\|7242931_7243669_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225577
NC_017030.1\|WP_014398547.1\|7255389_7256274_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|227339
NC_017030.1\|WP_167594389.1\|7254963_7255332_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_148282616.1\|7248375_7249566_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366664
NC_017030.1\|WP_014398533.1\|7235561_7236428_-\|NAD-dependent-protein-deacetylase	unknown	unknown	gnl\|CDD\|238700
NC_017030.1\|WP_014398540.1\|7247646_7248360_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_017030.1\|WP_014398529.1\|7228288_7230727_+\|penicillin-acylase-family-protein	unknown	unknown	gnl\|CDD\|376618
NC_017030.1\|WP_014398531.1\|7231829_7233371_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NC_017030.1\|WP_014398528.1\|7226888_7228292_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_017030.1\|WP_043323892.1\|7240570_7241374_+\|TonB-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|372476
NC_017030.1\|WP_014398536.1\|7241375_7242875_-\|amidase	unknown	unknown	gnl\|CDD\|223232
NC_017030.1\|WP_014398545.1\|7252916_7254950_+\|PKD-domain-containing-protein	unknown	unknown	gnl\|CDD\|372323
NC_017030.1\|WP_148282366.1\|7252353_7252656_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398534.1\|7236607_7239733_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014398539.1\|7246743_7247634_-\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	unknown	unknown	gnl\|CDD\|372627
NC_017030.1\|WP_014398542.1\|7249867_7250335_-\|putative-toxin-antitoxin-system-toxin-component,-PIN-family	unknown	unknown	gnl\|CDD\|379205
NC_017030.1\|WP_014398532.1\|7233385_7235404_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014398530.1\|7231145_7231826_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_017030.1\|WP_014398543.1\|7250502_7251117_+\|CAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|349398
NC_017030.1\|WP_014398544.1\|7251154_7252345_+\|cysteine-desulfurase-like-protein	unknown	unknown	gnl\|CDD\|273906

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014398537.1\|7242931_7243669_-\|hypothetical-protein	gnl\|CDD\|225577	COG3034, COG3034, Uncharacterized protein conserved in bacteria [Function unknown].	1.78336e-46
NC_017030.1\|WP_014398547.1\|7255389_7256274_-\|DMT-family-transporter	gnl\|CDD\|227339	COG5006, rhtA, Threonine/homoserine efflux transporter [Amino acid transport and metabolism].	5.6165e-86
NC_017030.1\|WP_148282616.1\|7248375_7249566_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|366664	pfam01476, LysM, LysM domain. The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.	3.67613e-12
NC_017030.1\|WP_014398533.1\|7235561_7236428_-\|NAD-dependent-protein-deacetylase	gnl\|CDD\|238700	cd01409, SIRT4, SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.	1.15537e-131
NC_017030.1\|WP_014398540.1\|7247646_7248360_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	1.69868e-145
NC_017030.1\|WP_014398529.1\|7228288_7230727_+\|penicillin-acylase-family-protein	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	0
NC_017030.1\|WP_014398531.1\|7231829_7233371_-\|GAF-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	4.38179e-68
NC_017030.1\|WP_014398528.1\|7226888_7228292_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.64541e-45
NC_017030.1\|WP_043323892.1\|7240570_7241374_+\|TonB-C-terminal-domain-containing-protein	gnl\|CDD\|372476	pfam13103, TonB_2, TonB C terminal. This family contains TonB members that are not captured by pfam03544.	0.00163164
NC_017030.1\|WP_014398536.1\|7241375_7242875_-\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	8.33555e-133
NC_017030.1\|WP_014398545.1\|7252916_7254950_+\|PKD-domain-containing-protein	gnl\|CDD\|372323	pfam12810, Gly_rich, Glycine rich protein. This family of proteins is greatly expanded in Trichomonas vaginalis. The proteins are composed of several glycine rich motifs interspersed through the sequence. Although many proteins have been annotated by similarity in the family these annotations given the biased composition of the sequences these are unlikely to be functionally relevant.	9.09751e-10
NC_017030.1\|WP_014398534.1\|7236607_7239733_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.72956e-75
NC_017030.1\|WP_014398539.1\|7246743_7247634_-\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	gnl\|CDD\|372627	pfam13532, 2OG-FeII_Oxy_2, 2OG-Fe(II) oxygenase superfamily.	5.79301e-37
NC_017030.1\|WP_014398542.1\|7249867_7250335_-\|putative-toxin-antitoxin-system-toxin-component,-PIN-family	gnl\|CDD\|379205	pfam13470, PIN_3, PIN domain. Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).	4.90268e-18
NC_017030.1\|WP_014398532.1\|7233385_7235404_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.8663e-92
NC_017030.1\|WP_014398530.1\|7231145_7231826_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	3.74728e-42
NC_017030.1\|WP_014398543.1\|7250502_7251117_+\|CAP-domain-containing-protein	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	3.66892e-41
NC_017030.1\|WP_014398544.1\|7251154_7252345_+\|cysteine-desulfurase-like-protein	gnl\|CDD\|273906	TIGR01976, am_tr_V_VC1184, cysteine desulfurase family protein, VC1184 subfamily. This model describes a subfamily of probable pyridoxal phosphate-dependent enzymes in the aminotransferase class V family (pfam00266). The most closely related characterized proteins are active as cysteine desulfurases, selenocysteine lyases, or both; some are involved in FeS cofactor biosynthesis and are designated NifS. An active site Cys residue present in those sequences, in motifs resembling GHHC or GSAC, is not found in this family. The function of members of this family is unknown, but seems unlike to be as an aminotransferase. [Unknown function, Enzymes of unknown specificity].	1.20709e-138

>NC_017030.1|WP_014398537.1|7242931_7243669_-|hypothetical-protein
MRILLACGVLLASLCAHAEDRVAAARKRQTAGLVQTFKAAGLSWPPEELYLRAFKVERELEVWAGRPGQPLVKVRTFPVCAASGEVGPKRAQGDLQVPEGFYTVDLFNPKSAYHLSLRVSYPNALDRKLGAAKPGGDIYIHGDCVSIGCLAIEDGPIEELYVMVSEARVRMGRDVPVHLFPRRLDAAGLAALEALSGVPDARKAFWRGLEPGYRLFEESRRPPRVKVDDSASAYVVSPAPQARVR
>NC_017030.1|WP_014398536.1|7241375_7242875_-|amidase
MKSSVPLQESGTAGGARALVSLTTTELAAALRERHVTSVEVLDAFLARARAHNPALNAVVTWDEAQARKRAEEADAALARGELWGPLHGVPFTVKDAFSTGGLRTTAAHPGFAEYVPAQDATVVARLKAAGAILFGKTNLPPFAGDFQTDGPLWGRTNNPHDLGRTPGGSSGGAAVAVAAGLTPFEVGSDIGGSIRQPAHYCGIVGIKPTEHRVSTFGHIPDPPGGPRHVRHMACAGPLARSVADVRLILSLIEGADPRAPEVPPVVPVGAAKPRALKGLRLAWADTLGPFQADRETRALFQRFTAAARAEGVVVEQAVPPGQDFTDLVEVWGLIEGAEVGAPLPPPVREGYQQQFLPFERDLLAKAILQGTRVDMTGYGTALSQRDVHIGLLEDFLSGWDAWLVPVALTAAPPHTPFGAPVDVDGAPRDYLESLGGFTCLFNATGSPVVVFPLGRTAAGLPVGAQLVGRRWMDGALLDVAEALLPLGGGVRWPAAFTP
>NC_017030.1|WP_043323892.1|7240570_7241374_+|TonB-C-terminal-domain-containing-protein
MRPGDPSLSAESLAAEEHARVSERVQGIVDERRARDRVDTGRIHPYFGQLRAQLEKQMDAPPLFDMPSFPKQLLYSYAEKARQFGASGSPGAMPGPRKPPKPGELLAKRARDEPGYNRLRGLSQAGEELQDFAHGVSTMKLTVTLELLQGPDGLLREVKLISRSGNRAYDDYVLQAVPPALGKSAAPPPDAMGVHTDGIRSVWAVEGRVVYVRKVSEMKKGADNIYLAALTAAGLLAGNFDETTGEVYVIDVRNPHFECRSRLLRVY
>NC_017030.1|WP_014398534.1|7236607_7239733_-|tetratricopeptide-repeat-protein
MPLACLDEPTFMDLLLGTLPSDRAALVDEHLDTCPSCRRMVSEALKVQPPADSGAAPEEEVLDSQLATLAVDPWRGKKLRLRLPTPPLARGTAVGRYLILEMLGVGGMSVVYAAYDPELDRRVALKLLQVEALGLGAEAGRTQVLREAQAMARVSHPHVVSVFDVGTFGRQVFLAMELVDAHTLRKWEHDGPHPWRQVVELFLAVARGLAAAHAVGVVHGDVKPENILVGQDGRVRVTDFGLSRIMFGAVAPPLMPGSPTHPRAMEGGTPAYMAPEQFPPEERTDARSDQFGFCAALYEGLYGERPFAGTTVEELSQAVHAGRVKSVPRHSGVPQWLRKVVVKGLSVKPEDRHASMEALIAALESDPAARRTRRLRVAGASLLLLSAVGLTHVLHGRDVTGCEGAARAMDGVWDAPRQQAVEAAFIGTQRRFAHDAFRHVRRGLDAYTAAWVTTRTAACEATRVRHEQSEAVMALRMRCLDARLADVAALTQLFTQADPDLVERAPRAVEGLTPLAGCSDVEALTSRGQSSPDDPAARDRTVALLQALVDARALRAAGRYSQGVARVEPVAQAARAAGDWSGAADALLLLAELKDGAGDYRGAEATVLQAAWTAEAGRNDDAAARAWTLAVRVTGERLDHYAQGQQAAERASAAVERLGASRELAGALAMNLGRLLSRQGRYPEAHEQLTRALSFLEKRFGPEALEVADVRVELGTVRRSQGRAEEALGLYERALGTVRGALGPEHPDVARIRLEQASVRWQQGDFVQSERLARGALALLERSLGQDHPQVADALNSLALALQYQGKREEALPLYERALGIAEKTEGRDSSTVAIIVNNIGTLLVHMGRLEEATQRFATALEQVEKSLGPDHPTLALVLRGMGQTLSYRNQPDQALPYFQRAAALQTSLPDDVNGGWTGALVDLGRTYMVLGRPREALAPLEQAVAGWERARPRPAERPAARYMLARALWDAKKDPARAVRLAAEARQEAGALPDDESSVPELRQAMDRWIARLPPAARRDIKAAMATPKPADPARDALVR
>NC_017030.1|WP_014398533.1|7235561_7236428_-|NAD-dependent-protein-deacetylase
MTLLSDSPVAALPPEAGVDALAKLLRGRRVVVLTGAGISTESGIPDYRGPETRHKVRNPIQHREFLHQPEVRQRYWARSLLGWPRFTTARPNDGHFALVALEKAGVVPGLITQNVDGLHSAAGSERVLELHGALSRVRCLACGAHEPRASLQARMLGLNPGFAHTVVELRPDGDAELSQEAVEGFRVPACTRCGGTLKPDVVFFGDNVAAPLVQDAFALVEEGDALLVVGSSLTVYSGYRFVTRAAERHMPIGILNIGESRGDGLADVRVEARAGEVLPRLAQALTRS
>NC_017030.1|WP_014398532.1|7233385_7235404_-|protein-kinase
MDTGRPLGGRYALERRIGGGGMGAIWRAVDLQLQRHVALKLIASDVVARTPEAHRHFEQEAQAVARLRHPHVVQVHDSGVDGGVPYIVMELLEGEDLETRLTQQGRLSPARVAALVTPVARALAAAHAAGLVHRDLKPANLFLAHVDGEEVVKVLDFGLARSLLPNGAPAQAEGLTGTLRYMSPEQLRADPDLDARADLWSLAVVLYRALTGQFPYGAESVGALLRGAFHPPAVPVSQLVPELGASGDAFFQRALSPTLAQRFTSARELAAAFVALVEAGRAGQAATVLVVDDEPDVELLMRQRFRRHVRDGVYRFVFARDGEEALEALRQHPDTHAVLCDLNMPRMDGLTFLSRVGEVDPLVKVVMVSAYGDLPNLRTAMNRGAFDFLVKPVDLDDLESTLAKTVRHVAELRRAVRSTEENALLRMFVHGGIVDRVLPLVRGPGGLAGEQVDATVAFLDVADFTAVTRQHPPESALRRLNANFEVILPELESRGGVVDKFLGDAVMAVFQGEGHVARALDACLAVRQRLQGLAWSGGDASPYAHGVCMGVDTGPVLSGNVGAAGRGRLDHTVLGDVVNTAARLATVAARDQVLVSEALAARLQDAFDCRLAGDRHLPGAGGQALAVREVVARHGSQSASSADRTSEQVAPAVMEAPASPPRPGAFTAKGPT
>NC_017030.1|WP_014398531.1|7231829_7233371_-|GAF-domain-containing-protein
MRVILNPGQVDERVVMLPEGTTTIGRTEENGIRVPHPSLSRRHARLERAGGRVVLVDLDSKNGSFVGPHRVSRQELGHGQSFRCGEVWFRLVSLDTPLPDGWGPLRTQPLETRFSGGSSMEALLDTRSPDRTRDKLQVLLKVGQILSSPGPVDGLLERVLQLVFQIWAVDRAAVLLVDRDTGTLEPRVSRGARGGALPERFYSQHIVDYVHSRGVAALFTDAQDDARLVGADSVFRQSIRASLCVPLRTRDAVLGVLYLDSLKQGGLFTDEDLEFLTAFANQAAIALDHAHLARRLEEEAVLRNAYQRFFPPDVVRQLKALRGVPLEVREANVTILFSDITGFTAMSSRLKPRQVVDMLNAYFPVMADVVFRHEGTLEKYIGDALMAVWGAPFARPDDADRAVRAAVEMQQALAALNARWRAEGVPEIQVHIGLNSGPVAAGNIGSERYLQYATVGDATNVAARVCGVARPGEVLITDATRALLDAGAFALEPLAPVRVKGRDEPLSLFRVLG
>NC_017030.1|WP_014398530.1|7231145_7231826_+|Crp/Fnr-family-transcriptional-regulator
MSYAQLLAEIPMFESLGREDLENMSSLLQPRRFARGEVIFHRGDVGTALFIIRRGQVAIRLSSSEGREITLALLDRGDAFGELSLLDGEMRSTDAMAREEAHLLTLQRDDFRRYLETRPQVSLALLANMSRLVRRTTQLVYDSAFLDARSRLVRVLLELAKTQGKQGPEGLVITPKLTQSELANLCGVTRESVNKWLRYYVREGMLSFEGGQIILLQPERLGQDAE
>NC_017030.1|WP_014398529.1|7228288_7230727_+|penicillin-acylase-family-protein
MSAFTQVLRMLRMLPSAMAVATPGVGPWLARRRWTREEGTLSLPGLHGKVEVLRDTWGVPHIFANDEHDLFFAQGYVHGQDRLWQLEMGRRLVDGRLATLLGPMGLSADRFLRTVGLRHMAEKSWEQVDPEARAILEAYSAGINARIAAEPLPYEFTVMATEPTPWTPVDSLARGNLLAMMLGGNHRIELFRARLVAAVGEEVANALLPQNAPETPLIVPKEARLPGLKDVKAMSGLDSVDAVMGDPNIVSGSNNWVVHGQRTKSGQPLLANDVHIPLSMPSTWYENGLHAGRFQHVGFSLPGVPMLIVGHNGKVAWGMSNLGPDTQDFYIEKLDDPKAPKKYLYQDVWHDLEVRREEIPVKGGAPVVLEVQSTRHGPLMNVVMAEELKDSEPLALKWAHRECQPLINSVLKLNLATDWESFRAAMKLWEGPGQNFVYADTAGNVGYQATGKIPIRQGHQGLIPMPGWTGESEWTGFIPFEELPASFNPPAGYAATANNKITSDDYPHLIAHNWFPGYRAKRITDLIEAGTQHTVESMRDIQAQTYSLPAEALRPYFLAAALPADDTQRQAVEALKAWDLRFEPEAVGATVFQAWYIEVLRKLLQHKLEPSLVKEYLMGQYERHGSLHMPFVIGLMSQPDSAWWDDPKTPEKETRDDILRAALGVATAWLVKTYGPKPEAWAWGQVHQLTYAHQMLGGPAIPGPIRRVFNSGPVPARGDNYSVDGASFLWSHPFKVVHGTALRMIVDLGDLSRSVSIHSPGQSEHLFHKHRDDLMELNRKVEFHPMLHTRQAVEQHREATLTLTPAVALVAK
>NC_017030.1|WP_014398528.1|7226888_7228292_+|MFS-transporter
MSLAQRLTITQPMRVFWITWFGQLISILGSGLTSFGVGAKVFLDTRSTTQFALLSFFALAPMVVLSPIAGTLIDRWDRRRAMLLADLGNGFTTLLIFSMLLASERGLFKLEPWHFYLPVALGACFGAFRWPAFFATVTLIVPKQHLGRANAMAEVASGASQILSPIIAGALIDSVGLKGVLTVDVCSFFIAVTTLLMVRFPRPTASAEGQQGKGSLLAEMKQGWAFISARKGLLSLMAFTGVAVLCMDLVVLLITPLVLAFTDISTLGRIASIAGVGALLGGIGMGVWGGPKNPLHGILGFHAFSGVVLFMAAPAPSVPLVATAAALYLFTMPPVMAGIQSIWQRKIPADLQGRAAAVKRMIILCVSPFAALIAGPLADDIFEPAMREGGALASTMGRLLGVGPGRGIAVIFIVLGLLTLTNVAAGWLNPRLRNLDKELPDALPDTPPATSDDTAAPNAPTAGASAS
>NC_017030.1|WP_014398539.1|7246743_7247634_-|alpha-ketoglutarate-dependent-dioxygenase-AlkB
MALPPRRGPGSPLARKAAQRTPGHHYNASFLNSADRAEILAWLGTLHPLWEERYSKHFPPPEGQQQRRLLRPVYWLGNWQFACLDYYRPPKGVQNRCVKAEPFPAVLQRQIEKVEALARRMFRGPDMPQGWHLNTCLVNFYGSRLEDGRWVDTARVGEHKDFEPGPVASLSLGERALIQFVTSTRPGERDAVVLEQWLDDGALQLFGGAQWKEQTFHRVQRVDTRAGHVMPPELPDFRTRRINLTFRYVPDAHVTPFATLSPEAREDVRPYMETLAKGSRFFREELAREQPPVKAE
>NC_017030.1|WP_014398540.1|7247646_7248360_-|purine-nucleoside-phosphorylase
MATPHISASPGDFAEVILMPGDPLRARYISERFLENARSVTAVRNMLGFTGTFRGKRLSVMGHGMGVPSISIYATELVRNYGAKVLIRVGSCGALRTDVKLRDVIVAMGAGTDSNVNRMRVMGHDFPAVADFTLARRAVEAAEKRNKPVRVGNVFTSDLFYHPQEALNATLEKMGILAVEMEIAGLYGVAAEFGARALSLLTVSDHLRTGEHLSPEDRQTTFDEMIELALDVAASEA
>NC_017030.1|WP_148282616.1|7248375_7249566_-|LysM-peptidoglycan-binding-domain-containing-protein
MPSPAEVAAVVTDAAVRENPCPVDAEEEDDEATAATDDEGVSEEGEMQAPLAPAAPSGPLYTADLSDEALAEAWKKDPATLGSMSIGFVESGRQINSVRVPDDKDWIVVSPDIAYGTQETVDYVAAAIRAVRAQYPNVPTLRVNRLSTKDGGYLRPHKSHQNGRDVDFGFYYPTAEPVRERERERYIDVAMNWALVRSLVVNTDVQMILVDKRVMKVLYDYALSIGEDKVWLDSLFNAGFNSLIKHARRHRDHFHVRFFNGRAQELGRRVAPLLALQPDQNLMMYKVRNGDTLGGIALRHNSSVVAIKKANRMRNTFLSIGRRLVIPLKGPCTHCPIPPPVQLPPRRLPPQAQAPALVNTEPAASGKLPNPCTPATPAPTPVAVPTGVPSGLSTGR
>NC_017030.1|WP_014398542.1|7249867_7250335_-|putative-toxin-antitoxin-system-toxin-component,-PIN-family
MTPSAVPAIRSVVLDTNVVLDVFVFDDVFTRPLAQALRSGALTAWADRHTLKELALVLAYPSFKLTADAQRTVRDAYGALVRIADGEGTPVELPPCRDRDDQKFLELAARAKASWLVSKDQRVLSMGGGRRLPFDVLSPRRASQALEAEGFTRSA
>NC_017030.1|WP_014398543.1|7250502_7251117_+|CAP-domain-containing-protein
MKPSSRSLCLTLLSAAALLGGCGGEEAPTSQGEGVVVPPVQTDVAGNGLSASAAYCDDVTTWDPAWVQFETDVLTLINQRRAAGATCGGVAKPAVGALTTNDKLRCAARKHSKDMGTNNFFSHTGSNGSTPWQRMASAGYSYRTAAENIAAGYGTAQAVVDGWMASTGHCNNIMNGALKQSGIGYYNAPSSTYRAYWTQDFGTP
>NC_017030.1|WP_014398544.1|7251154_7252345_+|cysteine-desulfurase-like-protein
MPSPFAEHFPALRSGFSYLDNAAGAQVPTYCIDAIHQFLSGGSCNVGQPYPASRVATALKARAREETAEFLNCRPDEVMLGPSATALTFQVGRAVSRLFKPGDEVVISELEHESNAAPWRALEAQGVKVTTWRASWPEGRLETSELRKLVTPRTRLVAVSAAANSVGATPDVAAAAEVAHGVGAWLFVDAVHSSPHHLPDVRAWGADFAVFSPYKVFGPHLGCLFVRRELLAGLPADKLWFMPDDGPQKFEPGTANHEGWAGWLGSLRYLRDVLGGGQPGREGLARAFQRIAQLEQPLLEATLEQLSRHPRVQLYGPKTSAGRVATFCFNVAGVSPRAVAEHLAEQGVGVAAGHYYATMAAEALGLMPDGAVRASLLHYNTAEDVGRLLAALDSLP
>NC_017030.1|WP_148282366.1|7252353_7252656_-|hypothetical-protein
MASVLFASQAWAQAPRNPRGRSSAWDTPCIRPLLELVSGLVKLVFGTLAFRAFWEPRSDAITDGLMGVFFVVMGVSEVMTGALRLRARRKEHAAPKTAQD
>NC_017030.1|WP_014398545.1|7252916_7254950_+|PKD-domain-containing-protein
MQRKSSSWLLCVALSFLALLTGCASEMRPDATGSVQVTTVAQNLASSDVARVELAISGPGMTPLNATLEHSGSQWTGVIGNIPAGADRTFSAQAFDASGIAIYEGQATGVTIQSGQTAMVVLLLQQRTAPTPFENSAPRISGISASTYQVRANQTVTLSLSASDADGDVLTYAWTADGGAFGNASVASPTWTAPATPGNYSLSVVVSDGRDAQSGMTLRIAVLQDTGNANVAVSFNTWPAVTQVKGTPFGQVAPGGAVTLDVTATDADGDALTYAWSDDCGGGFSATTATHGIWTAPASEPTGGQCKVTVTVTDGRGGSTTGTLRLNVIHLQVPTLPPVIGQVFQSAAVARAGDTVRLFATATDPEGAALTFTWSASGGTLATPITTANRSEVVWTAPADSGGSDMSVTLAVEDASGQRTTQGFTVQMQLCVQAVTSYLLKTNASAVPLVVTYRMVGGGGGGAGRVPGAEGARVEGSFTWGAAATLEVIVGGGGGFGYWTAGGAGAGGAGYFGGGAGGTSAGGAGGGGGGGSSAILSGGQLVAFAAGGGGGGVGGGGGSNTGGAPAVDFYGHQPKAGTAGTGGSTIFVSGGAGLTGGAGGESHMGGGGGFGGGGGGAGPAAQSFGGSSGGNGGASSGGMGANTWSTVTTLPTEAGASTTGGGNAGLVILKYDGACAL
>NC_017030.1|WP_167594389.1|7254963_7255332_-|hypothetical-protein
MLGTAGVLFASQARADGVDSALGALFGMAAAVLVLGGLALVVGMGTLFFNLSGRHGTASIVLGLLLGLGTLRLGLWTNGSFSDDGGLALLGGALLFLGAGEIAAAVRALRLGRDRSAAPKNL
>NC_017030.1|WP_014398547.1|7255389_7256274_-|DMT-family-transporter
MSEVAGRRVSALPPIPAVLIAVVSVQGGAALAKGLFPVLGSVGAAGLRLVLASVMLLAYFRPPLLRYTRAQWAAVVPYGVALGVMNLTYYLAIARIPLGLAVTLEFVGPFVLAVVGSRKVLDFVWVLFAATGIVLITPWTAKPGGLDPLGVVLALTAGACWALYILAGGRLSRRVPEGQGVAAGMVVAMLTVLPFMLREGHLERMTPGLFAAGVGVALLSSALPYSLEMMALGQLSSRTFGILMSLEPGVATVVGWLFLREHLSPLQWLAVALVSVASAGATLTAKQPPPPVEA

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Crispr_ID: NC_017030_30

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_30

7246417-7246715

Orphan

Consensus_repeat	Method
GGACCGCGGAAACCTGTCCGACTGTCGGACAGGTTT	PILER-CR

3 spacers

The CRISPR arrays of NC_017030_30

>merge|NC_017030|30|7246417-7246715|PILER-CR
AACCTGTCCGACTGTCCGACAGGTTTGGAAGCCCCTGAGACGGCCACGTCACCCGCAGTGGCCGAGAGGCCCCCGGGGCCAACCGGACCGCGGAAACCTGTCCGACAGTCGGACAGGTTTAGAGGACCGCGATGCCGCCGCCGGCCACCACCCGTGCCTGGCGGCTTCGAGCGACAGCTGGACCGCGGAAACCTGTCCGACAGGTTTGGACGATGCGAGGCCCGCCCCGTCACCCGCCGTGGCCGGGGGCTCCGGCGCCAGCCGGACCGCGGAAACCTGTCCGACTGTCGGACAGGTTT

>NC_017030|30|6|7246417-7246715|PILER-CR
AACCTGTCCGACTGTCCGACAGGTTTGGAAGCCCCT	GAGACGGCCACGTCACCCGCAGTGGCCGAGAGGCCCCCGGGGCCAACCGGACCGCGGA
AACCTGTCCGACAGTCGGACAGGTTTAGAGGACCGC	GATGCCGCCGCCGGCCACCACCCGTGCCTGGCGGCTTCGAGCGACAGCTGGACCGCGGA
AACCTGTCCGACAGGTTTGGACGATGCGAGGCCCGC	CCCGTCACCCGCCGTGGCCGGGGGCTCCGGCGCCAGCCGGACCGCGGAAACCTGTCCGACTG
TCGGACAGGTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014398537.1\|7242931_7243669_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225577
NC_017030.1\|WP_014398538.1\|7243965_7246362_+\|RIO1-family-protein	unknown	unknown	gnl\|CDD\|270696
NC_017030.1\|WP_148282616.1\|7248375_7249566_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|366664
NC_017030.1\|WP_014398533.1\|7235561_7236428_-\|NAD-dependent-protein-deacetylase	unknown	unknown	gnl\|CDD\|238700
NC_017030.1\|WP_014398540.1\|7247646_7248360_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_017030.1\|WP_014398529.1\|7228288_7230727_+\|penicillin-acylase-family-protein	unknown	unknown	gnl\|CDD\|376618
NC_017030.1\|WP_014398531.1\|7231829_7233371_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NC_017030.1\|WP_014398547.1\|7255389_7256274_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|227339
NC_017030.1\|WP_043323892.1\|7240570_7241374_+\|TonB-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|372476
NC_017030.1\|WP_014398536.1\|7241375_7242875_-\|amidase	unknown	unknown	gnl\|CDD\|223232
NC_017030.1\|WP_014398545.1\|7252916_7254950_+\|PKD-domain-containing-protein	unknown	unknown	gnl\|CDD\|372323
NC_017030.1\|WP_148282366.1\|7252353_7252656_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398534.1\|7236607_7239733_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014398539.1\|7246743_7247634_-\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	unknown	unknown	gnl\|CDD\|372627
NC_017030.1\|WP_167594389.1\|7254963_7255332_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398542.1\|7249867_7250335_-\|putative-toxin-antitoxin-system-toxin-component,-PIN-family	unknown	unknown	gnl\|CDD\|379205
NC_017030.1\|WP_014398532.1\|7233385_7235404_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_017030.1\|WP_014398530.1\|7231145_7231826_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_017030.1\|WP_014398543.1\|7250502_7251117_+\|CAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|349398
NC_017030.1\|WP_014398544.1\|7251154_7252345_+\|cysteine-desulfurase-like-protein	unknown	unknown	gnl\|CDD\|273906

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014398537.1\|7242931_7243669_-\|hypothetical-protein	gnl\|CDD\|225577	COG3034, COG3034, Uncharacterized protein conserved in bacteria [Function unknown].	1.78336e-46
NC_017030.1\|WP_014398538.1\|7243965_7246362_+\|RIO1-family-protein	gnl\|CDD\|270696	cd05145, RIO1_like, Catalytic domain of the atypical protein serine kinases, RIO1 and RIO3 kinases and similar proteins. RIO1 is present in archaea, bacteria and eukaryotes. In addition, RIO3 is present in multicellular eukaryotes. Both RIO1 and RIO3 are associated with precursors of 40S ribosomal subunits, just like RIO2. RIO1 is essential for survival and is required for 18S rRNA processing, proper cell cycle progression and chromosome maintenance. Although depletion of either RIO1 and RIO2 results in similar effects, the two kinases are not fully interchangeable. The specific function of RIO3 is unknown. RIO kinases are atypical protein serine kinases containing a kinase catalytic signature, but otherwise show very little sequence similarity to typical PKs. Serine kinases catalyze the transfer of the gamma-phosphoryl group from ATP to serine residues in protein substrates. The RIO catalytic domain is truncated compared to the catalytic domains of typical PKs, with deletions of the loops responsible for substrate binding. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).	2.66641e-58
NC_017030.1\|WP_148282616.1\|7248375_7249566_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|366664	pfam01476, LysM, LysM domain. The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.	3.67613e-12
NC_017030.1\|WP_014398533.1\|7235561_7236428_-\|NAD-dependent-protein-deacetylase	gnl\|CDD\|238700	cd01409, SIRT4, SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.	1.15537e-131
NC_017030.1\|WP_014398540.1\|7247646_7248360_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	1.69868e-145
NC_017030.1\|WP_014398529.1\|7228288_7230727_+\|penicillin-acylase-family-protein	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	0
NC_017030.1\|WP_014398531.1\|7231829_7233371_-\|GAF-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	4.38179e-68
NC_017030.1\|WP_014398547.1\|7255389_7256274_-\|DMT-family-transporter	gnl\|CDD\|227339	COG5006, rhtA, Threonine/homoserine efflux transporter [Amino acid transport and metabolism].	5.6165e-86
NC_017030.1\|WP_043323892.1\|7240570_7241374_+\|TonB-C-terminal-domain-containing-protein	gnl\|CDD\|372476	pfam13103, TonB_2, TonB C terminal. This family contains TonB members that are not captured by pfam03544.	0.00163164
NC_017030.1\|WP_014398536.1\|7241375_7242875_-\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	8.33555e-133
NC_017030.1\|WP_014398545.1\|7252916_7254950_+\|PKD-domain-containing-protein	gnl\|CDD\|372323	pfam12810, Gly_rich, Glycine rich protein. This family of proteins is greatly expanded in Trichomonas vaginalis. The proteins are composed of several glycine rich motifs interspersed through the sequence. Although many proteins have been annotated by similarity in the family these annotations given the biased composition of the sequences these are unlikely to be functionally relevant.	9.09751e-10
NC_017030.1\|WP_014398534.1\|7236607_7239733_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.72956e-75
NC_017030.1\|WP_014398539.1\|7246743_7247634_-\|alpha-ketoglutarate-dependent-dioxygenase-AlkB	gnl\|CDD\|372627	pfam13532, 2OG-FeII_Oxy_2, 2OG-Fe(II) oxygenase superfamily.	5.79301e-37
NC_017030.1\|WP_014398542.1\|7249867_7250335_-\|putative-toxin-antitoxin-system-toxin-component,-PIN-family	gnl\|CDD\|379205	pfam13470, PIN_3, PIN domain. Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).	4.90268e-18
NC_017030.1\|WP_014398532.1\|7233385_7235404_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.8663e-92
NC_017030.1\|WP_014398530.1\|7231145_7231826_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	3.74728e-42
NC_017030.1\|WP_014398543.1\|7250502_7251117_+\|CAP-domain-containing-protein	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	3.66892e-41
NC_017030.1\|WP_014398544.1\|7251154_7252345_+\|cysteine-desulfurase-like-protein	gnl\|CDD\|273906	TIGR01976, am_tr_V_VC1184, cysteine desulfurase family protein, VC1184 subfamily. This model describes a subfamily of probable pyridoxal phosphate-dependent enzymes in the aminotransferase class V family (pfam00266). The most closely related characterized proteins are active as cysteine desulfurases, selenocysteine lyases, or both; some are involved in FeS cofactor biosynthesis and are designated NifS. An active site Cys residue present in those sequences, in motifs resembling GHHC or GSAC, is not found in this family. The function of members of this family is unknown, but seems unlike to be as an aminotransferase. [Unknown function, Enzymes of unknown specificity].	1.20709e-138

>NC_017030.1|WP_014398538.1|7243965_7246362_+|RIO1-family-protein
MNDSLETLLADGIIDAVIGQLKTGKEAEVWLVQHAGQVVAAKLYKERHERNFRNNAGYKEGREVRNSRTRRAMEKGSRFGQAAAEEAWKNAEADSLYKLHAQGVRVPTPVMFYEGILLMELVLDAEGQPAPRLVEAPPQTPEEAEALYLDLRAQVVRTLCADLIHGDLSPYNILMSGNGPTIIDFPQTVAAARNSQAEFYFRRDLDNVRQYLAGFSTRLAGRSGDTGEIWNAYVRRELTPEFVPSGTFREAPRRQGAGRQASRQERFLQQEEARRNEAPPAPAPVAAVEEGLSAEEAELRALEALVLRQGGGERGRPIVTASPRDGRRRGGFGGKPPPRTGNAPRPGNGGPPQNAGARPPQGGGNNRPNGNNNGRPQQGGPRNGAPAQGATAPVAQGDARMNGRPQQGGPRNGNPRNEPRRDGRPPRQPNGEARMNGQPMGDNAQAPRMNGQPMGENVQASQQNGRPPRTNGQAYSENAQASQQNGRPPRMNGQAMGENVQASQQNGRPPRTNGQAYSENAQASQQNSRPPRTNGQAYSENAQASQQNGRPPRMNGQSRGGEAGMNGQPRMNGQSRGGEAGLNGQPRMNGQSRGGEAGLNGQPRMNGQPSGEHGQESQQNGRPPRMNGRSRGGESGLNGPSRQNEQPYGGEAGLNGSPRMNGQPHGGESDVNGPSQSQNGNGRPPRNEWRANGRPQQNGGPRQDGPGAQSRMNGRPPRNNGSFQDDAPQQNDEPRQNGRGPGSGPREARGNLPNNGPRMPRQGPERGAGRSSRGSAPQVSYVARPPAASSSNPETGSS
>NC_017030.1|WP_014398537.1|7242931_7243669_-|hypothetical-protein
MRILLACGVLLASLCAHAEDRVAAARKRQTAGLVQTFKAAGLSWPPEELYLRAFKVERELEVWAGRPGQPLVKVRTFPVCAASGEVGPKRAQGDLQVPEGFYTVDLFNPKSAYHLSLRVSYPNALDRKLGAAKPGGDIYIHGDCVSIGCLAIEDGPIEELYVMVSEARVRMGRDVPVHLFPRRLDAAGLAALEALSGVPDARKAFWRGLEPGYRLFEESRRPPRVKVDDSASAYVVSPAPQARVR
>NC_017030.1|WP_014398536.1|7241375_7242875_-|amidase
MKSSVPLQESGTAGGARALVSLTTTELAAALRERHVTSVEVLDAFLARARAHNPALNAVVTWDEAQARKRAEEADAALARGELWGPLHGVPFTVKDAFSTGGLRTTAAHPGFAEYVPAQDATVVARLKAAGAILFGKTNLPPFAGDFQTDGPLWGRTNNPHDLGRTPGGSSGGAAVAVAAGLTPFEVGSDIGGSIRQPAHYCGIVGIKPTEHRVSTFGHIPDPPGGPRHVRHMACAGPLARSVADVRLILSLIEGADPRAPEVPPVVPVGAAKPRALKGLRLAWADTLGPFQADRETRALFQRFTAAARAEGVVVEQAVPPGQDFTDLVEVWGLIEGAEVGAPLPPPVREGYQQQFLPFERDLLAKAILQGTRVDMTGYGTALSQRDVHIGLLEDFLSGWDAWLVPVALTAAPPHTPFGAPVDVDGAPRDYLESLGGFTCLFNATGSPVVVFPLGRTAAGLPVGAQLVGRRWMDGALLDVAEALLPLGGGVRWPAAFTP
>NC_017030.1|WP_043323892.1|7240570_7241374_+|TonB-C-terminal-domain-containing-protein
MRPGDPSLSAESLAAEEHARVSERVQGIVDERRARDRVDTGRIHPYFGQLRAQLEKQMDAPPLFDMPSFPKQLLYSYAEKARQFGASGSPGAMPGPRKPPKPGELLAKRARDEPGYNRLRGLSQAGEELQDFAHGVSTMKLTVTLELLQGPDGLLREVKLISRSGNRAYDDYVLQAVPPALGKSAAPPPDAMGVHTDGIRSVWAVEGRVVYVRKVSEMKKGADNIYLAALTAAGLLAGNFDETTGEVYVIDVRNPHFECRSRLLRVY
>NC_017030.1|WP_014398534.1|7236607_7239733_-|tetratricopeptide-repeat-protein
MPLACLDEPTFMDLLLGTLPSDRAALVDEHLDTCPSCRRMVSEALKVQPPADSGAAPEEEVLDSQLATLAVDPWRGKKLRLRLPTPPLARGTAVGRYLILEMLGVGGMSVVYAAYDPELDRRVALKLLQVEALGLGAEAGRTQVLREAQAMARVSHPHVVSVFDVGTFGRQVFLAMELVDAHTLRKWEHDGPHPWRQVVELFLAVARGLAAAHAVGVVHGDVKPENILVGQDGRVRVTDFGLSRIMFGAVAPPLMPGSPTHPRAMEGGTPAYMAPEQFPPEERTDARSDQFGFCAALYEGLYGERPFAGTTVEELSQAVHAGRVKSVPRHSGVPQWLRKVVVKGLSVKPEDRHASMEALIAALESDPAARRTRRLRVAGASLLLLSAVGLTHVLHGRDVTGCEGAARAMDGVWDAPRQQAVEAAFIGTQRRFAHDAFRHVRRGLDAYTAAWVTTRTAACEATRVRHEQSEAVMALRMRCLDARLADVAALTQLFTQADPDLVERAPRAVEGLTPLAGCSDVEALTSRGQSSPDDPAARDRTVALLQALVDARALRAAGRYSQGVARVEPVAQAARAAGDWSGAADALLLLAELKDGAGDYRGAEATVLQAAWTAEAGRNDDAAARAWTLAVRVTGERLDHYAQGQQAAERASAAVERLGASRELAGALAMNLGRLLSRQGRYPEAHEQLTRALSFLEKRFGPEALEVADVRVELGTVRRSQGRAEEALGLYERALGTVRGALGPEHPDVARIRLEQASVRWQQGDFVQSERLARGALALLERSLGQDHPQVADALNSLALALQYQGKREEALPLYERALGIAEKTEGRDSSTVAIIVNNIGTLLVHMGRLEEATQRFATALEQVEKSLGPDHPTLALVLRGMGQTLSYRNQPDQALPYFQRAAALQTSLPDDVNGGWTGALVDLGRTYMVLGRPREALAPLEQAVAGWERARPRPAERPAARYMLARALWDAKKDPARAVRLAAEARQEAGALPDDESSVPELRQAMDRWIARLPPAARRDIKAAMATPKPADPARDALVR
>NC_017030.1|WP_014398533.1|7235561_7236428_-|NAD-dependent-protein-deacetylase
MTLLSDSPVAALPPEAGVDALAKLLRGRRVVVLTGAGISTESGIPDYRGPETRHKVRNPIQHREFLHQPEVRQRYWARSLLGWPRFTTARPNDGHFALVALEKAGVVPGLITQNVDGLHSAAGSERVLELHGALSRVRCLACGAHEPRASLQARMLGLNPGFAHTVVELRPDGDAELSQEAVEGFRVPACTRCGGTLKPDVVFFGDNVAAPLVQDAFALVEEGDALLVVGSSLTVYSGYRFVTRAAERHMPIGILNIGESRGDGLADVRVEARAGEVLPRLAQALTRS
>NC_017030.1|WP_014398532.1|7233385_7235404_-|protein-kinase
MDTGRPLGGRYALERRIGGGGMGAIWRAVDLQLQRHVALKLIASDVVARTPEAHRHFEQEAQAVARLRHPHVVQVHDSGVDGGVPYIVMELLEGEDLETRLTQQGRLSPARVAALVTPVARALAAAHAAGLVHRDLKPANLFLAHVDGEEVVKVLDFGLARSLLPNGAPAQAEGLTGTLRYMSPEQLRADPDLDARADLWSLAVVLYRALTGQFPYGAESVGALLRGAFHPPAVPVSQLVPELGASGDAFFQRALSPTLAQRFTSARELAAAFVALVEAGRAGQAATVLVVDDEPDVELLMRQRFRRHVRDGVYRFVFARDGEEALEALRQHPDTHAVLCDLNMPRMDGLTFLSRVGEVDPLVKVVMVSAYGDLPNLRTAMNRGAFDFLVKPVDLDDLESTLAKTVRHVAELRRAVRSTEENALLRMFVHGGIVDRVLPLVRGPGGLAGEQVDATVAFLDVADFTAVTRQHPPESALRRLNANFEVILPELESRGGVVDKFLGDAVMAVFQGEGHVARALDACLAVRQRLQGLAWSGGDASPYAHGVCMGVDTGPVLSGNVGAAGRGRLDHTVLGDVVNTAARLATVAARDQVLVSEALAARLQDAFDCRLAGDRHLPGAGGQALAVREVVARHGSQSASSADRTSEQVAPAVMEAPASPPRPGAFTAKGPT
>NC_017030.1|WP_014398531.1|7231829_7233371_-|GAF-domain-containing-protein
MRVILNPGQVDERVVMLPEGTTTIGRTEENGIRVPHPSLSRRHARLERAGGRVVLVDLDSKNGSFVGPHRVSRQELGHGQSFRCGEVWFRLVSLDTPLPDGWGPLRTQPLETRFSGGSSMEALLDTRSPDRTRDKLQVLLKVGQILSSPGPVDGLLERVLQLVFQIWAVDRAAVLLVDRDTGTLEPRVSRGARGGALPERFYSQHIVDYVHSRGVAALFTDAQDDARLVGADSVFRQSIRASLCVPLRTRDAVLGVLYLDSLKQGGLFTDEDLEFLTAFANQAAIALDHAHLARRLEEEAVLRNAYQRFFPPDVVRQLKALRGVPLEVREANVTILFSDITGFTAMSSRLKPRQVVDMLNAYFPVMADVVFRHEGTLEKYIGDALMAVWGAPFARPDDADRAVRAAVEMQQALAALNARWRAEGVPEIQVHIGLNSGPVAAGNIGSERYLQYATVGDATNVAARVCGVARPGEVLITDATRALLDAGAFALEPLAPVRVKGRDEPLSLFRVLG
>NC_017030.1|WP_014398530.1|7231145_7231826_+|Crp/Fnr-family-transcriptional-regulator
MSYAQLLAEIPMFESLGREDLENMSSLLQPRRFARGEVIFHRGDVGTALFIIRRGQVAIRLSSSEGREITLALLDRGDAFGELSLLDGEMRSTDAMAREEAHLLTLQRDDFRRYLETRPQVSLALLANMSRLVRRTTQLVYDSAFLDARSRLVRVLLELAKTQGKQGPEGLVITPKLTQSELANLCGVTRESVNKWLRYYVREGMLSFEGGQIILLQPERLGQDAE
>NC_017030.1|WP_014398529.1|7228288_7230727_+|penicillin-acylase-family-protein
MSAFTQVLRMLRMLPSAMAVATPGVGPWLARRRWTREEGTLSLPGLHGKVEVLRDTWGVPHIFANDEHDLFFAQGYVHGQDRLWQLEMGRRLVDGRLATLLGPMGLSADRFLRTVGLRHMAEKSWEQVDPEARAILEAYSAGINARIAAEPLPYEFTVMATEPTPWTPVDSLARGNLLAMMLGGNHRIELFRARLVAAVGEEVANALLPQNAPETPLIVPKEARLPGLKDVKAMSGLDSVDAVMGDPNIVSGSNNWVVHGQRTKSGQPLLANDVHIPLSMPSTWYENGLHAGRFQHVGFSLPGVPMLIVGHNGKVAWGMSNLGPDTQDFYIEKLDDPKAPKKYLYQDVWHDLEVRREEIPVKGGAPVVLEVQSTRHGPLMNVVMAEELKDSEPLALKWAHRECQPLINSVLKLNLATDWESFRAAMKLWEGPGQNFVYADTAGNVGYQATGKIPIRQGHQGLIPMPGWTGESEWTGFIPFEELPASFNPPAGYAATANNKITSDDYPHLIAHNWFPGYRAKRITDLIEAGTQHTVESMRDIQAQTYSLPAEALRPYFLAAALPADDTQRQAVEALKAWDLRFEPEAVGATVFQAWYIEVLRKLLQHKLEPSLVKEYLMGQYERHGSLHMPFVIGLMSQPDSAWWDDPKTPEKETRDDILRAALGVATAWLVKTYGPKPEAWAWGQVHQLTYAHQMLGGPAIPGPIRRVFNSGPVPARGDNYSVDGASFLWSHPFKVVHGTALRMIVDLGDLSRSVSIHSPGQSEHLFHKHRDDLMELNRKVEFHPMLHTRQAVEQHREATLTLTPAVALVAK
>NC_017030.1|WP_014398539.1|7246743_7247634_-|alpha-ketoglutarate-dependent-dioxygenase-AlkB
MALPPRRGPGSPLARKAAQRTPGHHYNASFLNSADRAEILAWLGTLHPLWEERYSKHFPPPEGQQQRRLLRPVYWLGNWQFACLDYYRPPKGVQNRCVKAEPFPAVLQRQIEKVEALARRMFRGPDMPQGWHLNTCLVNFYGSRLEDGRWVDTARVGEHKDFEPGPVASLSLGERALIQFVTSTRPGERDAVVLEQWLDDGALQLFGGAQWKEQTFHRVQRVDTRAGHVMPPELPDFRTRRINLTFRYVPDAHVTPFATLSPEAREDVRPYMETLAKGSRFFREELAREQPPVKAE
>NC_017030.1|WP_014398540.1|7247646_7248360_-|purine-nucleoside-phosphorylase
MATPHISASPGDFAEVILMPGDPLRARYISERFLENARSVTAVRNMLGFTGTFRGKRLSVMGHGMGVPSISIYATELVRNYGAKVLIRVGSCGALRTDVKLRDVIVAMGAGTDSNVNRMRVMGHDFPAVADFTLARRAVEAAEKRNKPVRVGNVFTSDLFYHPQEALNATLEKMGILAVEMEIAGLYGVAAEFGARALSLLTVSDHLRTGEHLSPEDRQTTFDEMIELALDVAASEA
>NC_017030.1|WP_148282616.1|7248375_7249566_-|LysM-peptidoglycan-binding-domain-containing-protein
MPSPAEVAAVVTDAAVRENPCPVDAEEEDDEATAATDDEGVSEEGEMQAPLAPAAPSGPLYTADLSDEALAEAWKKDPATLGSMSIGFVESGRQINSVRVPDDKDWIVVSPDIAYGTQETVDYVAAAIRAVRAQYPNVPTLRVNRLSTKDGGYLRPHKSHQNGRDVDFGFYYPTAEPVRERERERYIDVAMNWALVRSLVVNTDVQMILVDKRVMKVLYDYALSIGEDKVWLDSLFNAGFNSLIKHARRHRDHFHVRFFNGRAQELGRRVAPLLALQPDQNLMMYKVRNGDTLGGIALRHNSSVVAIKKANRMRNTFLSIGRRLVIPLKGPCTHCPIPPPVQLPPRRLPPQAQAPALVNTEPAASGKLPNPCTPATPAPTPVAVPTGVPSGLSTGR
>NC_017030.1|WP_014398542.1|7249867_7250335_-|putative-toxin-antitoxin-system-toxin-component,-PIN-family
MTPSAVPAIRSVVLDTNVVLDVFVFDDVFTRPLAQALRSGALTAWADRHTLKELALVLAYPSFKLTADAQRTVRDAYGALVRIADGEGTPVELPPCRDRDDQKFLELAARAKASWLVSKDQRVLSMGGGRRLPFDVLSPRRASQALEAEGFTRSA
>NC_017030.1|WP_014398543.1|7250502_7251117_+|CAP-domain-containing-protein
MKPSSRSLCLTLLSAAALLGGCGGEEAPTSQGEGVVVPPVQTDVAGNGLSASAAYCDDVTTWDPAWVQFETDVLTLINQRRAAGATCGGVAKPAVGALTTNDKLRCAARKHSKDMGTNNFFSHTGSNGSTPWQRMASAGYSYRTAAENIAAGYGTAQAVVDGWMASTGHCNNIMNGALKQSGIGYYNAPSSTYRAYWTQDFGTP
>NC_017030.1|WP_014398544.1|7251154_7252345_+|cysteine-desulfurase-like-protein
MPSPFAEHFPALRSGFSYLDNAAGAQVPTYCIDAIHQFLSGGSCNVGQPYPASRVATALKARAREETAEFLNCRPDEVMLGPSATALTFQVGRAVSRLFKPGDEVVISELEHESNAAPWRALEAQGVKVTTWRASWPEGRLETSELRKLVTPRTRLVAVSAAANSVGATPDVAAAAEVAHGVGAWLFVDAVHSSPHHLPDVRAWGADFAVFSPYKVFGPHLGCLFVRRELLAGLPADKLWFMPDDGPQKFEPGTANHEGWAGWLGSLRYLRDVLGGGQPGREGLARAFQRIAQLEQPLLEATLEQLSRHPRVQLYGPKTSAGRVATFCFNVAGVSPRAVAEHLAEQGVGVAAGHYYATMAAEALGLMPDGAVRASLLHYNTAEDVGRLLAALDSLP
>NC_017030.1|WP_148282366.1|7252353_7252656_-|hypothetical-protein
MASVLFASQAWAQAPRNPRGRSSAWDTPCIRPLLELVSGLVKLVFGTLAFRAFWEPRSDAITDGLMGVFFVVMGVSEVMTGALRLRARRKEHAAPKTAQD
>NC_017030.1|WP_014398545.1|7252916_7254950_+|PKD-domain-containing-protein
MQRKSSSWLLCVALSFLALLTGCASEMRPDATGSVQVTTVAQNLASSDVARVELAISGPGMTPLNATLEHSGSQWTGVIGNIPAGADRTFSAQAFDASGIAIYEGQATGVTIQSGQTAMVVLLLQQRTAPTPFENSAPRISGISASTYQVRANQTVTLSLSASDADGDVLTYAWTADGGAFGNASVASPTWTAPATPGNYSLSVVVSDGRDAQSGMTLRIAVLQDTGNANVAVSFNTWPAVTQVKGTPFGQVAPGGAVTLDVTATDADGDALTYAWSDDCGGGFSATTATHGIWTAPASEPTGGQCKVTVTVTDGRGGSTTGTLRLNVIHLQVPTLPPVIGQVFQSAAVARAGDTVRLFATATDPEGAALTFTWSASGGTLATPITTANRSEVVWTAPADSGGSDMSVTLAVEDASGQRTTQGFTVQMQLCVQAVTSYLLKTNASAVPLVVTYRMVGGGGGGAGRVPGAEGARVEGSFTWGAAATLEVIVGGGGGFGYWTAGGAGAGGAGYFGGGAGGTSAGGAGGGGGGGSSAILSGGQLVAFAAGGGGGGVGGGGGSNTGGAPAVDFYGHQPKAGTAGTGGSTIFVSGGAGLTGGAGGESHMGGGGGFGGGGGGAGPAAQSFGGSSGGNGGASSGGMGANTWSTVTTLPTEAGASTTGGGNAGLVILKYDGACAL
>NC_017030.1|WP_167594389.1|7254963_7255332_-|hypothetical-protein
MLGTAGVLFASQARADGVDSALGALFGMAAAVLVLGGLALVVGMGTLFFNLSGRHGTASIVLGLLLGLGTLRLGLWTNGSFSDDGGLALLGGALLFLGAGEIAAAVRALRLGRDRSAAPKNL
>NC_017030.1|WP_014398547.1|7255389_7256274_-|DMT-family-transporter
MSEVAGRRVSALPPIPAVLIAVVSVQGGAALAKGLFPVLGSVGAAGLRLVLASVMLLAYFRPPLLRYTRAQWAAVVPYGVALGVMNLTYYLAIARIPLGLAVTLEFVGPFVLAVVGSRKVLDFVWVLFAATGIVLITPWTAKPGGLDPLGVVLALTAGACWALYILAGGRLSRRVPEGQGVAAGMVVAMLTVLPFMLREGHLERMTPGLFAAGVGVALLSSALPYSLEMMALGQLSSRTFGILMSLEPGVATVVGWLFLREHLSPLQWLAVALVSVASAGATLTAKQPPPPVEA

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Crispr_ID: NC_017030_31

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_31

7428733-7429047

Orphan

Consensus_repeat	Method
GTCCGACTGTCCGACAGGTTTTGGNCGGCCGCGGC	CRT
CTGTCCGACAGGTTTTGGGCGGCC	PILER-CR

4 spacers

The CRISPR arrays of NC_017030_31

>merge|NC_017030|31|7428733-7429047|CRT,PILER-CR
GTCCGACTGTCCGACAGGTTCTGGGCGGCCGCAGCCCATGAGGGCCTCTGCCCACCCGGACAGTGGAAACCGGTCCGACTGTCCGACAGGTTTTCGGCGGCCACGGCTGGCGGAGACCTCCTCCCATCCGGGCATTGGAAACCTGTCCGACAGGTTTTGGGCGGCTGCGGCTGACGGGTGTCGCCCTCCATCCAGGCCAAGGAAACGTGTCCGACTGTCCGACAGGTCTTGGCCGGCCGCGGCTGGCGGGAGCCTCGGCCCACCTGGGCCGCGGAAACCGGTCCGACTGTCGGACAGGTTTGGCCGCGCCGGGCG

>NC_017030|31|6|7428733-7429047|CRT
GTCCGACTGTCCGACAGGTTCTGGGCGGCCGCAGC	CCATGAGGGCCTCTGCCCACCCGGACAGTGGAAACCG
GTCCGACTGTCCGACAGGTTTTCGGCGGCCACGGC	TGGCGGAGACCTCCTCCCATCCGGGCATT
GGAAACCTGTCCGACAGGTTTTGGGCGGCTGCGGC	TGACGGGTGTCGCCCTCCATCCAGGCCAAGGAAACGT
GTCCGACTGTCCGACAGGTCTTGGCCGGCCGCGGC	TGGCGGGAGCCTCGGCCCACCTGGGCCGCGGAAACCG
GTCCGACTGTCGGACAGGTTTGGCCGCGCCGGGCG

>NC_017030|31|7|7428739-7428898|PILER-CR
CTGTCCGACAGGTTCTGGGCGGCC	GCAGCCCATGAGGGCCTCTGCCCACCCGGACAGTGGAAACCGGTCCGA
CTGTCCGACAGGTTTTCGGCGGCC	ACGGCTGGCGGAGACCTCCTCCCATCCGGGCATTGGAAAC
CTGTCCGACAGGTTTTGGGCGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014398668.1\|7415622_7417233_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|381601
NC_017030.1\|WP_014398675.1\|7424916_7426737_-\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|238518
NC_017030.1\|WP_014398681.1\|7434563_7436012_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238492
NC_017030.1\|WP_014398682.1\|7436021_7437278_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|227277
NC_017030.1\|WP_014398683.1\|7437406_7439512_-\|elongation-factor-G	unknown	unknown	gnl\|CDD\|234569
NC_017030.1\|WP_014398673.1\|7423745_7424456_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225818
NC_017030.1\|WP_014398680.1\|7432335_7434528_+\|DUF4082-domain-containing-protein	unknown	unknown	gnl\|CDD\|372556
NC_017030.1\|WP_014398685.1\|7441634_7442663_+\|prephenate-dehydrogenase/arogenate-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223364
NC_017030.1\|WP_014398671.1\|7421739_7422669_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_017030.1\|WP_148282619.1\|7422705_7423749_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_017030.1\|WP_014398669.1\|7417539_7420935_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057
NC_017030.1\|WP_014398677.1\|7429100_7430237_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_017030.1\|WP_043323947.1\|7440375_7441533_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239803
NC_017030.1\|WP_014398679.1\|7431615_7432137_+\|DUF2007-domain-containing-protein	unknown	unknown	gnl\|CDD\|378182
NC_017030.1\|WP_014398686.1\|7442659_7442956_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398674.1\|7424468_7424798_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_167594392.1\|7427033_7428278_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|274425
NC_017030.1\|WP_014398678.1\|7430258_7431398_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340836
NC_017030.1\|WP_014398667.1\|7415006_7415591_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_017030.1\|WP_014398670.1\|7421182_7421545_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014398668.1\|7415622_7417233_-\|peptidoglycan-binding-protein	gnl\|CDD\|381601	cd01021, GEWL, Goose egg-white lysozyme. Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.	2.25636e-90
NC_017030.1\|WP_014398675.1\|7424916_7426737_-\|aminopeptidase-P-family-protein	gnl\|CDD\|238518	cd01085, APP, X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.	3.49535e-121
NC_017030.1\|WP_014398681.1\|7434563_7436012_+\|hypothetical-protein	gnl\|CDD\|238492	cd00992, PDZ_signaling, PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of PDZ domains an N-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in proteases.	9.65312e-05
NC_017030.1\|WP_043323947.1\|7440375_7441533_+\|hypothetical-protein	gnl\|CDD\|239803	cd04276, ZnMc_MMP_like_2, Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin.	0.000150277
NC_017030.1\|WP_014398683.1\|7437406_7439512_-\|elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
NC_017030.1\|WP_014398673.1\|7423745_7424456_+\|response-regulator-transcription-factor	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	2.03026e-52
NC_017030.1\|WP_014398680.1\|7432335_7434528_+\|DUF4082-domain-containing-protein	gnl\|CDD\|372556	pfam13313, DUF4082, Domain of unknown function (DUF4082). This family appears to be a parallel beta-helix repeated region that sits between successive Cadherin domains, pfam00028.	2.05397e-58
NC_017030.1\|WP_014398671.1\|7421739_7422669_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.50188e-18
NC_017030.1\|WP_148282619.1\|7422705_7423749_+\|histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	5.03484e-38
NC_017030.1\|WP_014398669.1\|7417539_7420935_-\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	3.42763e-06
NC_017030.1\|WP_014398677.1\|7429100_7430237_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.37622e-51
NC_017030.1\|WP_014398679.1\|7431615_7432137_+\|DUF2007-domain-containing-protein	gnl\|CDD\|378182	pfam09413, DUF2007, Putative prokaryotic signal transducing protein. This is a family of putative prokaryotic signal transducing proteins of Pii-type.	9.33166e-08
NC_017030.1\|WP_014398685.1\|7441634_7442663_+\|prephenate-dehydrogenase/arogenate-dehydrogenase-family-protein	gnl\|CDD\|223364	COG0287, TyrA, Prephenate dehydrogenase [Amino acid transport and metabolism].	4.8264e-36
NC_017030.1\|WP_014398682.1\|7436021_7437278_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|227277	COG4941, COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription].	7.18898e-167
NC_017030.1\|WP_014398678.1\|7430258_7431398_-\|glycosyltransferase	gnl\|CDD\|340836	cd03807, GT4_WbnK-like, Shigella dysenteriae WbnK and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.	2.24308e-62
NC_017030.1\|WP_014398667.1\|7415006_7415591_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.11917e-09
NC_017030.1\|WP_167594392.1\|7427033_7428278_+\|glycosyltransferase	gnl\|CDD\|274425	TIGR03087, stp1, sugar transferase, PEP-CTERM/EpsH1 system associated. Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.	7.8984e-51

>NC_017030.1|WP_167594392.1|7427033_7428278_+|glycosyltransferase
MRRVLAILPYVPLPSDTGGTLRTLELVRALASRFTLDVLAVHRAGNDAEGFKRWLGELGVPASRLHLVDLPRVAPEETLNSTRAFLRGTPLTYVRFARQSVQDALRRVLAERGPFDIIHFDHLHMAQLLPLARRLNPTAHMVIDEHNVESQLLARMAPLSPPPMRPFLNWQFKRVERLERECVSQADTVLACSSVDAEQLRAMGAKLVQVVPNGVKLPDFAPRETRGDDLVFVGSMDWWPNEDAVLLLAREVWPLVSSELSTSKLMVVGRSPPASVRALENERLVVTGSVPSVAPYLARALATAIPLRAGSGTRLKVLEAAAAGVPVVATRLAVEGLPVVEGQHVLLAESPEEFAAALRRLRKDPDLCSRLAQNARRMAESFAWDGIGAGLGELYLNAVSVSGEAKKPSGAEAN
>NC_017030.1|WP_014398675.1|7424916_7426737_-|aminopeptidase-P-family-protein
MGLEQTQGAAARERIARVRQVMREHGVAAVWVPTSDPHLSTYVPARWKGREWASGFTGSLATLVVTQDYAGLWVDSRYWDQADAQLKGSGIATVRAMNAPGQSHLDWLAANVPQGQTVAVDGAVLGLGVARSAAAQLSAAGVVLRTDLDVVAEAWADRPPLPAAPVFAHALSPVSRTDKLRAVRAEMGVLGATHHFISTLDDVAWLMNLRGADVEHLPLFLAHLLVEPGGARLFIGAGKVPDALRAALEADGITLHPYDEAARALVALPDGTRLLVDPRRITHGLRQAVPRGVTVVEGLNPSTVAKSRKTDAELAHFRNAMEQDGAALCAFFAWFESALGREPITELTVDERLSAERARRPGFVSLSFSTIAAFNANAAMPHYRATKDSHATVCLPGQQPQGILLIDSGGQYTSGTTDITRVVPVGEPTPEQRRDFTLVLRGNINLSRARFPRGTRSPNLDALARAPLWAEGLDYGHGTGHGVGFFLNVHEGPHGFSPTLPNDLTTAMEPGMITSNEPGLYRPGRWGIRIENLIAAVPDRKTEFGDFLRFETLSLCPIDTRLVDPALLSREEVEWLNAYHATVRERLLPHVEGAAREWLIQRTQPL
>NC_017030.1|WP_014398674.1|7424468_7424798_-|hypothetical-protein
MRLTRALFPLLAILPLLACGDSDGGVGESCGEDGCDSGLSCRRDFPGTFCAQDCTAEGEGGGCPSGTLCTRQLDTLMCSPVCDSESDCRESYACNGVSSTNLKACQVKL
>NC_017030.1|WP_014398673.1|7423745_7424456_+|response-regulator-transcription-factor
MKVLIADDERLARAELRRLLTAFPEVEVVGEANHVDETCERVEALAPDLLLLDIQMPGGTGFDVLDRLEAPPDVVFTTAHDAHALRAFQVNALDYLLKPIEAARLAEALERVRQRGRTQRAVGAPVTPLERVFVRDGERCWLVALSQVPLFSSEGNYARLHLPDAEPLLARSLNHLEERLDPARFFRASRQHLINLDFVEALEPGPGGTLIARLRGGREVEMSRRQSQRFRERLSP
>NC_017030.1|WP_148282619.1|7422705_7423749_+|histidine-kinase
MRMTRSRGYTACQVGGWGLHTLLNIALSGAHGPPAVGWLIAGATGLGLTHVARRALRLHAWNRLPLPRLVARVLAAGLVLGLLQNTLVFLEAVFVFHVYSLREASWAGYFSSATMWSLVMGVWLTLYIAVQAVTHARRVELEHWKLEAAARSAELSFLQAQLQPHFLFNCLNGLRGLIVEDPIRAQEAVTRLSGLLRYALGARGPETVTLQRELQVVDDYLGLEAIRLEERLRVRMDVTPDALGVSVPAMLVQTLVENAIKHGIAPAPRGGEVSVKARIEDRALCLEVANTPGSPDVGAGTVDSGGVGLRNATERLRLLCGAAASLRLDQSQSTVTTARVHIPLEAA
>NC_017030.1|WP_014398671.1|7421739_7422669_+|alpha/beta-hydrolase
MRRILLALCTLPLLLGCATASPGGGATVARAAAPTPFRVQRSGQGRPLLLIPGLSSSGKVWDATVAHYQSRYDCHVFTLAGFAGQPAVPGPFLPTMRRALADYIRGQHLERPILVGHSLGGVLALAVAEDAPELLGGLVLVDSLPFLPAAMDPSATAESVRPQVEELSARMRMQPPDQRNAQTLRTLRGFITDEDNVQTAMRWSVDSDPETIINAFSELSTTDLRPELTRIQVPALVLGSWVALKGRVPKEQVEAVYRAQYRNLSGARVVLNDTARHFIMWDDPAGFLRETDAFLGALPAPVARMEPVH
>NC_017030.1|WP_014398670.1|7421182_7421545_-|hypothetical-protein
MPKPPQSRRWMLTAFLVWLPGLVHVFPLLGVYMLMFNKAYALALFVGFALTGLALGLIQALTRGLRALWLTPASFVAGWSPLPVLMALSAPFSVAWTLTLFTSAGCVGLGQWMLRSEDRA
>NC_017030.1|WP_014398669.1|7417539_7420935_-|hypothetical-protein
MTTPIDGSAAAAARAAAEAAARAAAEAAARAAAKAAAEAAAKAAAEAAAKAAAKQQTKQPTVKLFNDGFASGGAQNNRNGVNRLTGETTNPFATPLGTSGGHARPLSGPVPGTANGAVPVRADVNGAAPAADPKPPKAEALPDKPEELPKLFPELKDKSKEDLKKAYDSLNKLGTGSFSEKATALGELASQFPETVPNALERLGIQDDKLAKLATNSDALTSLGKLTDPKASKVDKAQAALTLAKVTGDTFAPEDLKGVLDTTLKGLPAAEKLVGAIGKWTDPNASATDKATATLELGKALKDFAGDKFPALANDLRKLDGSLRAAGAAITLVDPNASTQDKALAAAQLLAEVPDLKKDLKAFADVLKNAGVKNATDVAQQGARMADVKVKGLDPQLASKLTPDQLKKLEAAATRLGGPESMEAALKGITDPKALDNLVGQLGKVDAEAGKKLVGALGGMEHKVLNEVLSDPKTTEQFAKLAGKLDDDAAKIVSKLVTDMDSAAVKSLLKLTDKFGADALNTTVKTLGPLLDKAGSKLVGQGLKIMDKVLGKIGVEITADVAGKVFKNLAKVVPVAGALPNAIDAAKFEKESLELHGKNNDLGYFAHTAAALNVADAGLGIALDLTGVGVAVDVGASVLLGAAELAMDIGFTQEKAKYEADPKGYKAPDWMKAVNLAGAAAQGPAGLAHMAAYYGPEGTAQLIQWGVEKAAKGAVKAAEFVGVSQAELAGEGLKGAAKVIHKLADVVRNPSQYGEAAVKAATEAFNTAIEKGGELAKEAKQVLDNVIDGAKKLGEKGLETLKYIAQNPGEAAKKALDGIKSVVNSGLDLATDAGKALYKQAVSTLNDLKAGYDKLTGAAKEKAKELIDGATTLVSNTVNKAKELGEKGLELLAWTAQNPGEAAAKAKEAIGDALAKGGELAKKAWESVKDLGAAGAELAEGLVKGLANAGEKAVETLKYIAENPGEALTKAGEWVGGALSDLARKGGELANAAAGALKDMIDFGGRRLEWAKGFARDLLKDGVESFKNVAKAWKDNLSEGGKELLIAVADLGDAGVDALKDLAGVGGQLAEAAVGHLSDLAKKSIEGAKEALGALADFGGEVGELAGDAFNGVKDFLDDLIPDDIPGVPFV
>NC_017030.1|WP_014398668.1|7415622_7417233_-|peptidoglycan-binding-protein
MSLSATTSQRTNSVYSNRSQALTTSAVRNSANPNAILSQYQPTGASARTARQDGLQPGVAASTKMAQTDLARLQQYKGNIEAAAAKHGLPPALLAAIASRESRAGAALDRTGHGDGGNGFGVMQVDHRYHTTKGGPTSAEHIDQAAGILKGYVNDMKKAHPDWSEAQQLRGAVAAYNSGPGNVRTLAGMDQGTTGNDYSNDVWARAQALAPHFGGAATNAGTINNASTPTRPSRNADTFEPASSTQRPGAKTWSAAPSMDQVMVRGNNLREGMQGPAVKQIQEMLGVPADGKFGPVTRKAVEDFQRANGVRAGNNAGQVGPDTLRALQGNRPGGTTNTQGTTNTQGTTNTQGTTNTQGTNNNGAVLGNGVRINTNDPTLQKLATSRLNNGQTGYCVRTTLDNMTRLGIPNTPAATGNDPNNPRGGMAQMLRNGWESIPFPGAQQKAIKSPYGNATANVVTADQYRKLVADGKVPDGAIIFQSRHGWDYSGGSKGNDMGIVRNGGKTTHNYQSMNSIIYSDCKEVVILVPKGAIQRD
>NC_017030.1|WP_014398667.1|7415006_7415591_+|TetR/AcrR-family-transcriptional-regulator
MTQKTEQKQKSHDAILASAATLLLERGIQASSIMDVMKGAGLTVGGFYGHFDSKEHLFTETLRSTARTAWNALLRKAKEDAPDAPALKVLERYLSRKHRDAATPTCPLPSITAEVSRAGEPYRGGLEAELQEFVRSYAELLPSGARRREKALAAIALMYGALSLARAVRGTKLGDEFLDAARKLGAELLTKEGT
>NC_017030.1|WP_014398677.1|7429100_7430237_-|glycosyltransferase-family-4-protein
MPHSAILHVRSTCGLYGAERALLSLAASTPSPWHAQVCSLVPPGRVDVLSGAAREQGLDALTLEVPGRFSAMAVATLASEVRRRGVGLLHAHDYKSLTLGAAASALAGVPLVATYHGDTGATPALIAYEGFARVLGNCTRAVAAVSRELTARLRRYVHRSPVVYIPNALPLADECTEAERLQAREALGLAPEGSVIALVGRLSVEKGPQVLLDAMQRLARTPGATVPTLLLVGDGPLRESLEAQAQGLPVRFLGFRSEVRSVYAAADAVVMPSLREGMPLVALEAMALGRPLVASGVGELPHVLGTGRGLVVPPGDAGTLASALAGLLTAPGWRTRMAQAAREYVVAHHAPERMANRYIESLYLPALLDPREEQAAAG
>NC_017030.1|WP_014398678.1|7430258_7431398_-|glycosyltransferase
MKNEMHPTARPTRVAHVMYGLEMGGLEQLVVRLSQHGRERGIESVVLALGPDGPVRELLQRANVPTVWLGGLAGMTPAAIRRLAQEVDAFGADVVHGHDVGPWLNAVATRTLRPRTPVMGTFHQTVEPQGKLRPAAMAAAMFTQSLVACGSEVRASLERWSPKLLSNVVTIENGVPLEVATGEEARRAARERLGLPQDATVVGYLGRLSEEKGPDLLVDAFLRHFADAKDTHLVMIGPGPMEASLRARAAASPLAGRVHFTGALLEASKLLPAFDVYVQPSRREGRSLSLLEAMAVGLPTVSHAIPAIREVHSDGQTALLVKSEDVDALGGAVKRLTHDAELRSRLGEAAKREAQRYSLSTMVDTYAKLYRGAAARAQA
>NC_017030.1|WP_014398679.1|7431615_7432137_+|DUF2007-domain-containing-protein
MGIPDHDFQLLTTCGDESEAALVRALLQADNIPCIIQGEQHRSMLGVAGAYIELRVLVPASELEHARELLKSVARGEPPVGFAPAPDADSEEAHCALHAQRATGTCQRCGTFLCASCDGASAGLCEDCAERNDSGAGIQRGRKRKVIAWLILLFLFGPPFLLMLASTLNALLR
>NC_017030.1|WP_014398680.1|7432335_7434528_+|DUF4082-domain-containing-protein
MLRHASRWVTTFVLGFTWIQTGCAPAETSPQEIAETTTAEQPLLPGERSLLGTTALPAVQSADDSGAVELGVRFRSDAPGRIMGVRFYKGTGNTGTHTGSLWTASGTLLATATFQNETASGWQEVRFASPVTIAADTNYVVSYHAPAGHYSVTSNGFASALDVLPLHAEATSNGLYRYGTSGFPTSSFNASNYWVDVAFLPNDTTAPRAPTNVTAVPSSSTAIDLTWYASVDGTGEMQGNARWHLVYRNGQLIAELPGTTVRYRDTGLTPSTGHNYTVRGRDAAGNVSAASTVVTATTLPNMACNPCSLWNSVTGDPQYENADATPTEVGVKFRTDVAGTVTKVRYYKGSTDTGPHVGHLWSATGALLATTETTPAETGFGWRELSFPTPVSLTANTTYVVSYFATGGRYAITPYYFSTAGVDMPPLHAPSTVEAGGNGVRNLNGSAFPTEAWLNTNFWVDVTFVPEEPSGPATVDLAVTQSFPAGTGANGDVLFYDLTVTNNGPATATNVVLDVPIPTGLNYFFYSATPGSSGGCSFFSDLQCTTASLAPGATFTVHVEAIPLSAGTFTSQATVSSSQVDFVPGNNTHALTIPVGPSTNLVTFDTIPGQDETLNGTYGPIQFGLNSWYIASPWGGFTTKSVSFNGGGPTQANLGIIGQRRILGLDAFTWDSGATLTLKCIDLPTLTFPLTAGQVTHVVPTWTQPCTVFTVITSNGWDTNFDNLELSPRP
>NC_017030.1|WP_014398681.1|7434563_7436012_+|hypothetical-protein
MPAAPLLLSAATSLLATTWLLAAAPSSVAVEPSGFTVQSDGKAVIITQVVPGRPADRAKLTPGTRILRIESPERTFARGPIEQLNQTDLHDALIATWDEPLLLFVGNTREDGRYIGLQRDDPRPAEEFPGFPLPPEKRARLSLLQQQLHEARRLRELHRTPREKPGLELRHQSEAWVKGGQLRSVDGGGFTGLWIHPELTLDARCPDRLEKVVLSGPGKGLPRTFQPAEDSVSTGQDFTFDLPLWSVRDVTRACAAGKSSLAVTLRAELSCKDEPALQQPLPVKLSLKCEQKLPDEEAGGLRLLSLRGAPEEYVTGTKAAFTAEASGLDSVVPPVASVTFVEVDARGKVQQRFATVPVPPGATEATAELTLDTSTARTVRLSVEARFADGSTRGSDTREVNVVTPAFVEARSKGYEEGSRRGRALDQRFTQEIPTPCADIAATVAWLKAQPEVESAHGTGKHNFDYRVKGSGITQVVSCHAP
>NC_017030.1|WP_014398682.1|7436021_7437278_-|RNA-polymerase-sigma-factor
MSKAQAAVHAVWRIESARLIAGLARMVRDVGQAEELAQDALVVALEKWPVSGVPENPGAWLMATAKRRAIDEMRRHKLLARKHEELGHGLEEAEVPDLDAALDDDVGDDLLRLIFTSCHPVLSPEARVALTLRLLGGLTTDEIARAFLVPEPTVAQRIVRAKRTLAEKGVPFEVPHGEALAARLASVLEVVYLIFNEGYSATAGDGWMRPELCQDALRLGRILAELAPGEPEVHGLVALMEIQASRSRARVGPSGEPVLLLEQNRALWDQLLIRRGLAALERSEKAGPAGPYTLQAAIAACHARARTPEETDWPRIAALYGVLARLTPSPVVELNRAVALSMAFGPAVGLELVDQLVAEPSLKHYHLLPSVRGDLLQKLGRLKEAKAEFERAASLTRNAKEQALLRARAAACSGEKRS
>NC_017030.1|WP_014398683.1|7437406_7439512_-|elongation-factor-G
MSRTTRIERYRNIGIMAHIDAGKTTLTERVLFFTGRIHSTGEVHTGSTEMDWMEQEKKRGITITSAATTAFWQPRHGREAGVPHRINILDTPGHVDFTIEVERSLRVLDGAVAVFDASQGVEPQSETVWRQADRYGVPRIAFINKMDKVGADFALSVQSMVDRLGVRPVAVQWPVGDGADFQGLVDLVRMRLVRFQGDDGGFDDGAPVPPELMEAVLPYRMRLIEVCADLDAGVMEKFVDGRVEDITAEELERALRSGTLARTLVPVLCGSAFKKKGVQMLLDAVVSYLPSPADVASVEGFAPVTGERVSRPVSDSGPPTALAFKLMSDKAVGGIVFLRVYSGTLRAGTVLLNPVTGRKERVGRLMFMHANRREEVAEVHAGDLCAALGLKGVRTGDTLCDPEAPVVLEALNVMEPVVQLAVEARSPAELPKLEEGLQRLAAEDPSLRLGVDPESGQVLLSGMGELHLEVVVDRLRTEFGVEARVGQPKVAYRDTLRSAVRQEYRHVRQSGGPGQYARVVLDVGPAPRGAGLVFVDATKGGSIPRELVPAIEKGVAGAMAKGMREGVPLVDVEVRLVDGDTHVKDSTPQAFMVAGSLALQEAARRVGVQGLEPVMEVEVVTPEEFLGDVLGDLASRRGRVLGMEAKGAARCVSARVPMARLFGYVTALRGRTQGRAVASMRLGTYEPVPESAAGLAAEARA
>NC_017030.1|WP_043323947.1|7440375_7441533_+|hypothetical-protein
MTQDGTDYQVSAVQPVYLCALNAVDTDGDGVCDAAENQYGTNPNNSDTDGDRISDFAELYGYGGVDLRYWGADPLKKDVFVEVDYYADRKPTQGALDRVTTAFANAPVSNPNGTTGIALHLVLDSQIAAADVISNLDTGWVGVDTIKSKYFKSRRAPFFHYALFANTYGTTTSSGLSRGIPAHDLIVTLGGWSTPGGTELQQAGTLMHELGHNIGLRHGGTDDANYKPNYLSVMNYEYQTFGLRIDGVDNVLDYSRVRVASVTETSVNEVSAFAPIAPTTEADLARIGVRINGVQRTGTASANLDINGSGAIQAASFAYNFNRDSDSVDLFPASQNDWLALVYDGAGQIGDGWLGTTQGLSRQQPFFVVPEKTDSCLTEQMLLKR
>NC_017030.1|WP_014398685.1|7441634_7442663_+|prephenate-dehydrogenase/arogenate-dehydrogenase-family-protein
MSHVALVGYGRFGRALGTLLEAVGVEHRALDPVADIPEPLRAHSVGELLEGAELVVVAVPVPQMRDVLRSLRAHLRPEHLVLDVGSVKVKPVEALMEVLGAQVPWVGTHPLFGPLSLAMAERPMRVVLCPNPLHPEAAPRARRFYEGLGCEVIEQTPEGHDQVMARTHALTFFVAKGMVDSGAAADVPFAPASFKALSRTIETVRADAGHLFNAIQQENPFATQARGQLLAALQDIHRDLEAAPPATQAPETSGVAVPGLEPEAPSPREPREHIDALDRELVELLARRQELARRQRRAQEAGNEPARTETLLAVRRAWARELGVDAQEVEAVFRVVLGSSLR
>NC_017030.1|WP_014398686.1|7442659_7442956_+|hypothetical-protein
MTRRQARKTQAWQREAAEVKRILEQEARLGGTYALVAGELQHWTRMPRDGALVRDFMLMSDGLAIRLSHYLKRHGRAFSTREEAEFVLFGEESSGVLD

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Crispr_ID: NC_017030_32

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_32

7746870-7747294

Orphan

Consensus_repeat	Method
CCNNCGTCCNNGCCNCCGTCNNN	CRT

8 spacers

The CRISPR arrays of NC_017030_32

>merge|NC_017030|32|7746870-7747294|CRT
TCCTGCCGGTCGACGTCGCCCGGCGAACTTCCGCCGTCGCGCGGGTTGGATTCCGTCTCCTCCTCGCCCTCGCTGCCGCCGTCCGCGCCACCATCGCGCGAGTCGCCTTCGCCCTCGTCCTGGCCACCGTCGCCCTGACCACCGTCACCGCCGCCGTCGCTGGGACCGCCGTCACCGCCGCCGTCCTGGCCCCCATCCGAGCCACCGTCGCCAGGACCGGCATCGCCGCCGCCACCGTCCGTGCCGCCGTCCTGACCGCCATCCTGCCCACCGCCGTCCTGGCCTCCGTCGGCCCCGCCGTCCGCGCCACCATCCGGACCGCCGTCCTGGCCTCCGTCCTGCGGCGTGCCGCCGTCACCCTTCTGGCCGCCGTCCTCGCCCGCGTCCGGACGTCCGCCGTCGTTGCCGCCGTCCTGGCCTCCGTC

>NC_017030|32|7|7746870-7747294|CRT
TCCTGCCGGTCGACGTCGCC	CGGCGAACTTCCGCCGTCGCGCGGGTTGGATTCCGTCTCC
TCCTCGCCCTCGCTGCCGCC	GTCCGCGCCACCATCGCGCGAGTCGCCTTCG
CCCTCGTCCTGGCCACCGTC	GCCCTGACCACCGTCACCGCCGCCGTCGCTGGGA
CCGCCGTCACCGCCGCCGTC	CTGGCCCCCATCCGAGCCACCGTCGCCAGGACCGGCATCGCCGCCG
CCACCGTCCGTGCCGCCGTC	CTGACCGCCATCCTGCCCA
CCGCCGTCCTGGCCTCCGTC	GGCCCCGCCGTCCGCGCCACCATCCGGA
CCGCCGTCCTGGCCTCCGTC	CTGCGGCGTGCCGCCGTCACCCTTCTGG
CCGCCGTCCTCGCCCGCGTC	CGGACGTCCGCCGTCGTTG
CCGCCGTCCTGGCCTCCGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014398948.1\|7756485_7758207_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_017030.1\|WP_014398936.1\|7744177_7744903_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|377965
NC_017030.1\|WP_014398928.1\|7738980_7739472_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014398941.1\|7749828_7750812_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_148282621.1\|7740752_7741100_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_043324055.1\|7748843_7749854_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238744
NC_017030.1\|WP_014398943.1\|7751714_7752704_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_017030.1\|WP_014398947.1\|7755969_7756467_+\|GDYXXLXY-domain-containing-protein	unknown	unknown	gnl\|CDD\|379571
NC_017030.1\|WP_014398931.1\|7741239_7742055_-\|flagellar-M-ring-protein-FliF	unknown	unknown	gnl\|CDD\|274190
NC_017030.1\|WP_014398937.1\|7744902_7746780_-\|protein-BatD	unknown	unknown	gnl\|CDD\|379280
NC_017030.1\|WP_014398944.1\|7752820_7753801_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|184875
NC_017030.1\|WP_043324053.1\|7747788_7748844_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238744
NC_017030.1\|WP_043324052.1\|7743299_7743629_+\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NC_017030.1\|WP_014398932.1\|7742071_7742560_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_043322000.1\|7739468_7740620_-\|type-III-secretion-system-cytoplasmic-ring-protein-SctQ	unknown	unknown	gnl\|CDD\|274196
NC_017030.1\|WP_014398946.1\|7754863_7755973_+\|DUF4401-domain-containing-protein	unknown	unknown	gnl\|CDD\|379574
NC_017030.1\|WP_014398942.1\|7750808_7751690_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NC_017030.1\|WP_014398945.1\|7753850_7754861_+\|DUF2157-domain-containing-protein	unknown	unknown	gnl\|CDD\|378311
NC_017030.1\|WP_014398935.1\|7743646_7744048_-\|response-regulator	unknown	unknown	gnl\|CDD\|381100
NC_017030.1\|WP_014398933.1\|7742572_7743070_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014398936.1\|7744177_7744903_-\|SH3-domain-containing-protein	gnl\|CDD\|377965	pfam08239, SH3_3, Bacterial SH3 domain.	0.000597078
NC_017030.1\|WP_014398948.1\|7756485_7758207_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.60618e-67
NC_017030.1\|WP_014398943.1\|7751714_7752704_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	7.01459e-94
NC_017030.1\|WP_043324055.1\|7748843_7749854_-\|VWA-domain-containing-protein	gnl\|CDD\|238744	cd01467, vWA_BatA_type, VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.	2.10084e-70
NC_017030.1\|WP_014398942.1\|7750808_7751690_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.50868e-34
NC_017030.1\|WP_014398937.1\|7744902_7746780_-\|protein-BatD	gnl\|CDD\|379280	pfam13584, BatD, Oxygen tolerance. This family of proteins carries up to three membrane spanning regions and is involved in tolerance to oxygen in in Bacteroides spp.	1.89293e-138
NC_017030.1\|WP_014398944.1\|7752820_7753801_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|184875	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional.	1.06661e-30
NC_017030.1\|WP_043324053.1\|7747788_7748844_-\|VWA-domain-containing-protein	gnl\|CDD\|238744	cd01467, vWA_BatA_type, VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.	2.78965e-36
NC_017030.1\|WP_014398931.1\|7741239_7742055_-\|flagellar-M-ring-protein-FliF	gnl\|CDD\|274190	TIGR02544, YOP_proteins_translocation_lipoprotein, type III secretion apparatus lipoprotein, YscJ/HrcJ family. All members of this protein family are predicted lipoproteins with a conserved Cys near the N-terminus for cleavage and modification, and are part of known or predicted type III secretion systems. Members are found in both plant and animal pathogens, including the obligately intracellular chlamydial species and (non-pathogenic) root nodule bacteria. The most closely related proteins outside this family are examples of the flagellar M-ring protein FliF. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	2.08681e-37
NC_017030.1\|WP_014398946.1\|7754863_7755973_+\|DUF4401-domain-containing-protein	gnl\|CDD\|379574	pfam14351, DUF4401, Domain of unknown function (DUF4401). This family of proteins is found in bacteria. Proteins in this family are typically between 357 and 735 amino acids in length. The family is found in association with pfam09925. There is a single completely conserved residue K that may be functionally important.	2.57543e-47
NC_017030.1\|WP_043322000.1\|7739468_7740620_-\|type-III-secretion-system-cytoplasmic-ring-protein-SctQ	gnl\|CDD\|274196	TIGR02551, translocation_protein_Q, type III secretion system apparatus protein YscQ/HrcQ. Genes in this family are found in type III secretion operons. The gene (YscQ) in Yersinia is essential for YOPs secretion, while SpaO in Shigella is involved in the Surface Presentation of Antigens apparatus found on the virulence plasmid, and HrcQ is involved in the Harpin secretory system in organisms like Pseudomonas syringae. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	1.70506e-21
NC_017030.1\|WP_014398947.1\|7755969_7756467_+\|GDYXXLXY-domain-containing-protein	gnl\|CDD\|379571	pfam14345, GDYXXLXY, GDYXXLXY protein. This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 171 and 199 amino acids in length. It contains a conserved GDYXXLXY motif.	1.55041e-42
NC_017030.1\|WP_043324052.1\|7743299_7743629_+\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	1.68477e-08
NC_017030.1\|WP_014398935.1\|7743646_7744048_-\|response-regulator	gnl\|CDD\|381100	cd17548, REC_DivK-like, phosphoacceptor receiver (REC) domain of DivK and similar proteins. Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.41494e-29
NC_017030.1\|WP_014398945.1\|7753850_7754861_+\|DUF2157-domain-containing-protein	gnl\|CDD\|378311	pfam09925, DUF2157, Predicted membrane protein (DUF2157). This domain, found in various hypothetical prokaryotic proteins, has no known function.	5.34005e-28

>NC_017030.1|WP_014398937.1|7744902_7746780_-|protein-BatD
MRRTGSGRTALLAVLALLATAPAWAADIEFYQTVDRTEVGTDDTFKLTVVMVDAPSNAQLRLPQSNDFEVLSSSRGSQRSISLSGGGPAVIQDITRHELLMRPLRAGKLTLPPATLTAGGRTYRTDAVQLTVREGRVGNAPQAQQGGRPQLPDPFRNFRNMPDPFGDDDSDLRDDEPVIPRGDSDLFLRASLDRDDLYVGEQATLSLYIYSRVDLSSVDAVTMPKLEGFWTEEVESPTQLTGEQKVVDGIPYRAYLLRRRALFPVKSGTLLITPAEADITTGFLFAGHRVHRVSNGLKVKVRPLPNGAPPNMSNANVGSWRMSLDVSQTRVELGQPITVKVILEGQGNVKNVTPPKLTGPAALKVYEPTTTDRLTPNRNRIQGRRVVEYLVMPQRTGTFTLPELRFPYFDPSRRQYETARTDPVTITVEAGAGGVSSLPSAMTPSQVADAANEQKNVLTTGGLRPVRARAHFVGPSQPVWMRPFFLAGVLAPLGLLAGVAFAGGMRGRLATRSEAGRGRQQAKAARKRLAEAEKLKAGSDSGAFYVEVERAMVGFLEAQLGFPVGGLTREALGEKLAAAGVDAERRARVLFVLEACDLGRYGGGVEPGERRKVLATAAAVMEGWA
>NC_017030.1|WP_014398936.1|7744177_7744903_-|SH3-domain-containing-protein
MSDAATQGYYTAEEAEAVFQQANDAYGREDYATAQAQYEKLIAHGFGGPDVLYNLGTTHLARGDLGRAVLALEQARKQGGRAEDLEANLALARARQVDKVVGAAADEAFLPRLAAATDGAAVAWVFFVAWLVGFALLLFRRAFPSMRRTAVAVVAGLCLTAAVPAALLLGAHIWVHQNVHEAVVLAPTLVARELPRSEGRSLFEVHAGLKVQLLDETGKYVRIRLPNGLEGWAERDGVSEI
>NC_017030.1|WP_014398935.1|7743646_7744048_-|response-regulator
MAGNAQAPFHILLVEDEPVIRELVRSMLSDGAVDVVCAANGIEGLKLARDRDFHLILMDVVLPQLDGVSVCRILKSDPATAKVPLYMLTGKAKKADVESATQAGADGYIHKPFRGAELMDLVERLRAARSAAD
>NC_017030.1|WP_043324052.1|7743299_7743629_+|PilZ-domain-containing-protein
MNPSNGPRPNERERYHPRVEARLQVKVLLSGRTVTAQARDISMNGLFLQAHPADSQRALTIALPLPGDRELVTMCTIRRREVDGVALEFGELDWDDLIALARFLHPHLP
>NC_017030.1|WP_014398933.1|7742572_7743070_-|hypothetical-protein
MEDRRIPSLSIAPSIARQTPKTEFGPTLARAAREVVRTGAGLVGGMLPSGPISSAVVSTLSGTVSAAVPAEAVSSVPATGGATAMSARASTAGTTASTGSAATGQGDAWDLLEAQKLMAADGQKFNMAYVALQNAMQKESREHNAISNIMKVRHDSAKAAINNIR
>NC_017030.1|WP_014398932.1|7742071_7742560_-|hypothetical-protein
MAIDKLGAVGGAGPSPAVESGRETFNKVLEGVRTPQSRPVPVTTEGPPKPVRTPTEATAGTSRADGVERAKAGCAEVKPGSRVDSAQAARSQQAVEMLDRVGQAQQRLDHILKLAESGRTFSPSELLALQAHVYRASQELDLAGKVVEKATGGVKQVLQTQV
>NC_017030.1|WP_014398931.1|7741239_7742055_-|flagellar-M-ring-protein-FliF
MRSAPLRCLCLLLLLGASACRERIQHGLDERQANELQTVLVERGLDARKVPEPGKKPTWAIEVTDAQSSDAVRILAELGLPRLAAETGCDVFGGSGLVRSPLEEQVCRVRGMERELEKTLQTVDGVLLARVHLVVPPPPRPGQASAPSKASAMLRTAPGGATRVRKSADMLRELIAGGVEGLSPEAVSLLVDEVTTHVEAPSPKGGPVPLRLRVVLALLGVLVTGLSGALVWTTLRWKHYRALAEQPPAAPPAPPTPARPVVTPGSTRKLA
>NC_017030.1|WP_148282621.1|7740752_7741100_-|hypothetical-protein
MVVCVLARERAAELLGGLVDAEAGRALRHLERFAAMPSAQRQAKVAVEFGERADGANRLALFLETAPEALRQEAFRGLPPYHRSRFPQWEGAESRADAAPALTALAERRIREALR
>NC_017030.1|WP_043322000.1|7739468_7740620_-|type-III-secretion-system-cytoplasmic-ring-protein-SctQ
MQTNPVRTPSAVKKPTRPFRPGARRLTRAHLVLGQRPQVGRWGAELLRDVGAALSRDLGAAVKVEGHLVPAAVQPERELAVGMVFALVELSAVGGTAIVELEVPLVFAALARLAGTGLRPAPVAELTRLEESTLVYLLLSTLAAMRGQGEWVRRLGPRLSAVSMRRGDVLTRVDTRQPYVAVLLTATVDGATVGGRVLLPARAVQTAFQELPLEPGGATAPQVLAASIPARCLMGRSPLQASAVDALAAGDVVLFEGVRLRDGRVEGQGQLITRGFALRGEFLAEGFSTGSVHSRAARQESDMVATNKRSEAMPPLPVDVEIELTRLMLPLAELAALKPGTLLPLHVNASSPVLLRVGDRVVARAELVEIEGEVGARILALLP
>NC_017030.1|WP_014398928.1|7738980_7739472_-|hypothetical-protein
MSAPVNTLLSSFSPRGRLLFASALLVGLATLAPLGGLSLVGTSRLLIGATALAGLGWVFLRKGGMAGSADATAPEPLSIVSRTGLSQRCGLALVEADGRRYLVAYGDTFAEIHETRTMAVLPGATPRPTVKSRFDLELEPTVLFPRARPTKTACGALRKRGGG
>NC_017030.1|WP_043324053.1|7747788_7748844_-|VWA-domain-containing-protein
MPTLDAWRFTLLGYQVGLAQPLFLGLFGVGLLLGLLALLKALGRRTRLSALIAERHVTALAPGVSVWRPAVQGGLYGLGLMLFGLALAQPQCGTKSELTKRRGIDVVVALDASKSMLARDVQPSRLDRARLELNTLLDELKGDRAGLVVFAGDAFVQSPLTSDYSAVKLFLRAVDPDAMPQGGTNVGAALRLAKQVLDNADRGSKERVVVLLSDGEDLTGDVREATEALKDARVQVLAVGVGSDSGEPIPVYDRRGEFVDYKKDSNGDTVITRLDRAGLTAIADATGGAFFYQPNGVAMGQVVERIDQLQKSELESRVTVRYDERFQWFAIPGLVLLVLGMALIPSRRRAA
>NC_017030.1|WP_043324055.1|7748843_7749854_-|VWA-domain-containing-protein
MPPDLAFNNPEALWALLLAPLLLALAFWERKRRATLRFSAAHVFAKGGRGFRTYLLPLLPILRAAAVIAAVIAIARPQSRDSRVRDLSVEGIDIVVALDLSTSMEAGDFRPQNRLNVAKEVLTEFISGRVNDRLGLVVFSGAAYTQSPLTLDYGVLKEVLKQLRTRVLEDGTAIGDAIATSLNRLRDSDAKSRVVVLITDGDNNAGKISPLDAANMAASLHIPIYTILVGKGGKVPFPQGTDLFGNTVWRETEIPINPELMQDIADRTGGEYYRATDPEGLKQGLQKVLDALERSKLMEGGASATYKENFHPFLLVAFGLAALELLLRATVLRVFP
>NC_017030.1|WP_014398941.1|7749828_7750812_-|hypothetical-protein
MRHALVLAAVLFVSSPAVWAQAPKAPVALETVTPTGASARVEPEAVHIGEPFTYQVTLTHPKDQRYELVAPTGEGAVELLQQTRQRQDNANDATTTFGLRFSAFDLGDVQLPDLAFDVATPEGPRRFVLKGKTVEVTSTLPPDAQGQGAELFDYQPPQEVPIRSWTLLYALAVALAVAVAVWALVRWWQRRPKREKVVPVLPLDVRVRQSLDALKREDLPGRGHVKDFYFRLSEIVRGYLGERYGFEALECTSSELMASLRRLPTPGLPEDALMRFVSESDMVKYARADASPESCNQALAFGYDLLAKTYVPPAPPKPDAAPGPRVQ
>NC_017030.1|WP_014398942.1|7750808_7751690_-|DUF58-domain-containing-protein
MLPKDLIRRIRKLEIRTRKVVSDMLAGQYHSVFKGRGMAFSEVRQYQPGDEIRFIDWNVTARMNEAYIKVFTEERELTVMLLVDVSASNEFGSKDRTKAEVAAEVAAQIAFSAIANNDRVGLILFSDRVEKVVPPRKGRMHVLRLVSDILTFKPKGHGTDLSAGLTYLTQVAKRKAVTFLVSDFLATGYEKPLRLVGRRHDLVPVVIEDPLEQRFPAHGLVEMEDPETGERFVVDTSSTAVRGRFMRAMQAQRDERRKLFKKLELDHVELRAGDDHGKALANFFRARARRMAA
>NC_017030.1|WP_014398943.1|7751714_7752704_-|MoxR-family-ATPase
MNTDIRALTERVQQESSFVEVLNQETGKVIVGQRYMLERILIGLLCNGHVLLEGVPGLAKTLTVRTVADSLSATFMRVQFTPDLLPADLVGTMIYNQQTAAFTVRKGPIFANIVLADEINRAPAKVQSALLEAMAERQVTIGDQTFGLPSPFLVLATMNPIEQEGTYPLPEAQVDRFMLKVKVGYPTRDEEKVIMDRMSGGSSPKVQRVISLEHLVRARELVHAIYMDEKVKEYILNVVFATREPARYGLKDLADYIQFGASPRATIALAQAARAHAFLRHRGFVTPEDVKAIAFDVLRHRIAMTYEAEAEELTQEKIIQRVFDRVEVP
>NC_017030.1|WP_014398944.1|7752820_7753801_+|alpha/beta-fold-hydrolase
MSRPTPPRRSPLPPRWDAAGRPGAPGATPPVGPVETGLLAQLAPAVVPQVHWLPGGGAVRILEGGPPEGARSTIVFLHGRGNAATHWFPYLTALARHHRVLALDLPGFGQSTPADVHVRSAEDAVRFFTAPVEESLGMVAPGPVSVVGHSLGGLVALELALRGTVPVERLVLVDAMGLGPEMPRASRLFFRAGPERLARNLGPWAMARMLPPPPTPLGEKLGQLGYELLSVPGGRPEAAQAFNALVPLTGPLFHRRERLGEVKVPVLLIWGERDETLPVSLADEAARHLPQARALRVACGHSPQLEHPERVLPELKAFLDAEPSSP
>NC_017030.1|WP_014398945.1|7753850_7754861_+|DUF2157-domain-containing-protein
MPKDFLDLEATPERLHALADAGILRPDAYGRALHLAVASPSRPAWRAFLSTTLMALGSLLVLAGVVYFFAFNWAELGRFSKLGLICLGIAGAAVGAWRLGDRPAGQFALLAAAVLVGPLLAVYGQTYQTGADPYELFIGWGVLILPWVALARFTPLWMLQLVLVNTGVILFWGQRMTRFGAYEARLALVLGLLNGFAWATYEHFANQKVSWLQGRWMPRVLSLMTLMPLVTLGILFIVSRHDRSIESGVSLLLVLGALVAIYALHRHLHGELFLLTVGALSVITLVTTAVGYFLVEVTRADELTLFILPMVLIGEVALAVYWLRHESQATGVSEET
>NC_017030.1|WP_014398946.1|7754863_7755973_+|DUF4401-domain-containing-protein
MALRPTIQDVLAGLKAEGHVDEGVDARARTALEIRQKTLGASPWFVKALAGGGAWLSAAFLLSFFACVGLWKEEVALTAMGLVLTVAAVLLRRTSQGPFMEQLALALCMAGVGAFLVGLAQLEQNTLTVAFAGAVASVVLLAVYPDLILYFLATVGLCVSVGVFALDAVGGAGVDVWMLLCAAALSGILLFEPLLRRGQLGPRVGPIAFALACAVPGWLLFRNFESAQEGFRYVFRFESEFVPSAYLSILLALLLGWTGWRVLRELGLSREQRVWVPAVCALVLLTVMTLNTPGVLVAVLMLTLGFHRRSRVMLGLAVAFLLTFGAYYYYDLHITLLAKALALTGSGLVLLGVRQFFLRRQSAVLTEAR
>NC_017030.1|WP_014398947.1|7755969_7756467_+|GDYXXLXY-domain-containing-protein
MKRGAVIFGGLALVFVALAFLVVQKETVLARGQPVLLRLAPVDPRSLIQGDYMVLDYAINQGWREGREQPQEDGNVVLRLDEHNVGEFVRYETPGTPLAPGEVRLRFRIRNSQMRLGAEAFFFQEGHAERYANARFGELRVTDNGTSVLVGLRDENYQPLGSAIR
>NC_017030.1|WP_014398948.1|7756485_7758207_-|sigma-54-dependent-Fis-family-transcriptional-regulator
MQDELAQLMAALRDSRDFETAAAATLRRMLAVADAAVAASRYAGRARVLRGIVHLRPGEAYRRLAALDVGAREVTDAGVGTPFFTSATAWRAVVEHRCAVSIDVNIGTVQPHAPDAPVTGDPGLAGFHSNESKQRFLGRHATHVCVLPLRTPSGMEGMISLEADCLAAMGQEFVWRDAGDLLQLLTDIAAPYLTALPQRPVATPEVDEFLPVVGRSMAELLPILRTFALQDETILVSGATGAGKSRLARWCHERSGRRGKPFETLDLVTVPEDLQMAELFGWKKGAFTGAVRDAPGVVARSDGGTLFIDEIDKLSLKAQAGLLHLLESRSYRPLGEGTGEKLADVRFIIGTNADLLAQVRAGRFREDLYYRVNVLPVRMPPLQDRQDEIPLWARYMVNRRHRERLPEGSARLAPEAELLLTTSSWPGNLRQLDNIVRRAYTLAMVEHAGSTGDLVLLEKHVARALDYEQSPGGRPLPEALRAAAQAFVGEARRRGTPLDLDYADGFRGLVLGLAIRQVGRDEAFRLLGRESLVKNRNHHKALKRELEKVDGLYKALGEDGSPFSDLLENEDAD

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Crispr_ID: NC_017030_33

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_33

7950399-7950715

Orphan

Consensus_repeat	Method
ATCCCCGGGCTCCAGCGAAGCCACCGCCC	PILER-CR

4 spacers

The CRISPR arrays of NC_017030_33

>merge|NC_017030|33|7950399-7950715|PILER-CR
ATCCCCGCGCTCCAGCGAAGCCGCCGCCCTCATCAGCGCGGCGCTGGGACAACCACCGGCTGCGGCAACATCCCAGGGCTCCAGCGAAGCCACCGCGCCCACCAGCGCGGCTTCGGAACAGCCGCGTCCTCAAGCATCGGCCGCGCCAGATTCCTCGCGCGCGAGCGAAGCCGCCGACCTCATCAGCGCGGCGTTGGGACAACCATCGGCTGCGGCAACATCCCCGGGCTCCAGCGAAGCCACCGCACTCATCAGCGCGGCGTTGGGCCAACCATCGGCTGCGGCAGCATCCCCGGGCTCCAGCGAAGCCACCGCGC

>NC_017030|33|8|7950399-7950715|PILER-CR
ATCCCCGCGCTCCAGCGAAGCCGCCGCCC	TCATCAGCGCGGCGCTGGGACAACCACCGGCTGCGGCAAC
ATCCCAGGGCTCCAGCGAAGCCACCGCGC	CCACCAGCGCGGCTTCGGAACAGCCGCGTCCTCAAGCATCGGCCGCGCCAGA
TTCCTCGCGCGCGAGCGAAGCCGCCGACC	TCATCAGCGCGGCGTTGGGACAACCATCGGCTGCGGCAAC
ATCCCCGGGCTCCAGCGAAGCCACCGCAC	TCATCAGCGCGGCGTTGGGCCAACCATCGGCTGCGGCAGC
ATCCCCGGGCTCCAGCGAAGCCACCGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014399094.1\|7939156_7939594_+\|serine-acetyltransferase	unknown	unknown	gnl\|CDD\|100045
NC_017030.1\|WP_014399093.1\|7937981_7939175_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379214
NC_017030.1\|WP_014399100.1\|7944152_7946846_+\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NC_017030.1\|WP_014399101.1\|7946842_7947508_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399097.1\|7941354_7942125_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399096.1\|7941022_7941187_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399108.1\|7960103_7960820_-\|glycerophosphoryl-diester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176506
NC_017030.1\|WP_014399111.1\|7961958_7964034_-\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|372687
NC_017030.1\|WP_148282389.1\|7933338_7937946_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|188527
NC_017030.1\|WP_014399099.1\|7943358_7943916_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_148282390.1\|7939901_7940951_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399112.1\|7964202_7964883_+\|polyhydroxyalkanoate-synthesis-regulator-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|369568
NC_017030.1\|WP_014399103.1\|7952648_7953272_+\|outer-membrane-beta-barrel-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399110.1\|7961160_7961952_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399105.1\|7954718_7955540_+\|EI24-domain-containing-protein	unknown	unknown	gnl\|CDD\|377798
NC_017030.1\|WP_014399104.1\|7953321_7954659_-\|glutamate--cysteine-ligase	unknown	unknown	gnl\|CDD\|130503
NC_017030.1\|WP_043322039.1\|7960939_7961164_+\|twin-arginine-translocase-TatA/TatE-family-subunit	unknown	unknown	gnl\|CDD\|184862
NC_017030.1\|WP_014399107.1\|7959194_7960103_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_043322036.1\|7955757_7959003_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|274843
NC_017030.1\|WP_014399098.1\|7942169_7943228_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|369540

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014399094.1\|7939156_7939594_+\|serine-acetyltransferase	gnl\|CDD\|100045	cd03354, LbH_SAT, Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-cysteine. This reaction represents a key metabolic point of regulation for the cysteine biosynthetic pathway due to its feedback inhibition by cysteine. The enzyme is a 175 kDa homohexamer, composed of a dimer of homotrimers. Each subunit contains an N-terminal alpha helical region and a C-terminal left-handed beta-helix (LbH) subdomain with 5 turns, each containing a hexapeptide repeat motif characteristic of the acyltransferase superfamily of enzymes. The trimer interface mainly involves the C-terminal LbH subdomain while the dimer (of trimers) interface is mediated by the N-terminal alpha helical subdomain.	3.36592e-25
NC_017030.1\|WP_014399093.1\|7937981_7939175_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379214	pfam13480, Acetyltransf_6, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions.	3.26921e-29
NC_017030.1\|WP_014399100.1\|7944152_7946846_+\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NC_017030.1\|WP_014399104.1\|7953321_7954659_-\|glutamate--cysteine-ligase	gnl\|CDD\|130503	TIGR01436, Glutamate--cysteine_ligase_chloroplastic, glutamate--cysteine ligase, plant type. This model represents one of two highly dissimilar forms of glutamate--cysteine ligase (gamma-glutamylcysteine synthetase), an enzyme of glutathione biosynthesis. The other type is modeled by TIGR01434. This type is found in plants (with a probable transit peptide), root nodule and other bacteria, but not E. coli and closely related species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	5.27446e-118
NC_017030.1\|WP_014399108.1\|7960103_7960820_-\|glycerophosphoryl-diester-phosphodiesterase	gnl\|CDD\|176506	cd08563, GDPD_TtGDE_like, Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase (TtGDE, EC 3.1.4.46) and its uncharacterized homologs. Members in this family show high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. Despite the fact that most of GDPD family members exist as the monomer, TtGDE can function as a dimeric unit. Its catalytic mechanism is based on the general base-acid catalysis, which is similar to that of phosphoinositide-specific phospholipases C (PI-PLCs, EC 3.1.4.11). A divalent metal cation is required for the enzyme activity of TtGDE.	1.33037e-65
NC_017030.1\|WP_014399111.1\|7961958_7964034_-\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|372687	pfam13717, zinc_ribbon_4, zinc-ribbon domain. This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR, pfam12773.	1.15044e-16
NC_017030.1\|WP_148282389.1\|7933338_7937946_+\|hypothetical-protein	gnl\|CDD\|188527	TIGR04012, poly_gGlu_PgsB, poly-gamma-glutamate synthase PgsB/CapB. Of four genes commonly found to be involved in biosynthesis and export of poly-gamma-glutamate, pgsB(capB) and pgsC(capC) are found to be involved in the synthesis per se. Members of this family are designated PgsB, a nomeclature that covers both cases in which the poly-gamma-glutamate is secreted and those in which it is retained to form capsular material.PgsB has been shown to have poly-gamma-glutamate activity by itself but is bound tightly by PgsC (TIGR04011). [Cell envelope, Other].	8.14608e-61
NC_017030.1\|WP_014399112.1\|7964202_7964883_+\|polyhydroxyalkanoate-synthesis-regulator-DNA-binding-domain-containing-protein	gnl\|CDD\|369568	pfam07879, PHB_acc_N, PHB/PHA accumulation regulator DNA-binding domain. This domain is found at the N-terminus of the Polyhydroxyalkanoate (PHA) synthesis regulators. These regulators have been shown to directly bind DNA and PHA. The invariant nature of this domain compared to the C-terminal pfam05233 domain(s) suggests that it contains the DNA-binding function.	9.62926e-31
NC_017030.1\|WP_014399105.1\|7954718_7955540_+\|EI24-domain-containing-protein	gnl\|CDD\|377798	pfam07264, EI24, Etoposide-induced protein 2.4 (EI24). This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53. It has been suggested to play an important role in negative cell growth control.	7.16008e-15
NC_017030.1\|WP_043322039.1\|7960939_7961164_+\|twin-arginine-translocase-TatA/TatE-family-subunit	gnl\|CDD\|184862	PRK14860, tatA, twin arginine translocase protein A; Provisional.	3.52526e-10
NC_017030.1\|WP_043322036.1\|7955757_7959003_+\|PDZ-domain-containing-protein	gnl\|CDD\|274843	TIGR03900, carboxyl-terminal_protease_family_protein, putative carboxyl-terminal-processing protease, deltaproteobacterial. This model describes a multidomain protein of about 1070 residues, restricted to the order Myxococcales in the Deltaproteobacteria. Members contain a PDZ domain (pfam00595), an S41 family peptidase domain (pfam03572), and an SH3 domain (pfam06347). A core region of this family, including PDZ and S41 regions, is described by TIGR00225, C-terminal processing peptidase, which recognizes the Prc protease. The species distribution of this family approximates that of largely Deltaproteobacterial C-terminal putative protein-sorting domain, TIGR03901, analogous to LPXTG and PEP-CTERM, but the co-occurrence may reflect shared restriction to the Myxococcales rather than a substrate/target relationship.	0
NC_017030.1\|WP_014399098.1\|7942169_7943228_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|369540	pfam07819, PGAP1, PGAP1-like protein. The sequences found in this family are similar to PGAP1. This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body.	0.000120791

>NC_017030.1|WP_014399101.1|7946842_7947508_+|hypothetical-protein
MSPRASSRPLAFLTAALLLGGCTKEASTSEEGQEADARTLQKLRAEADRVKQGGAVATRPQPPQREPEESKLAGLAAGMGDSGPRKLRLPERNDTVHVDTVAMKVTGLEASHSVKGSGKAGLGLTTEDLFLRVELITQNVGGMPAPLTLEGVKLTDAKGQTYPLARDAQAVAGTKPLPSTWAPAQRTEVALLFEVPPDAVQDDGLALVVQGSGGDVRIPLR
>NC_017030.1|WP_014399100.1|7944152_7946846_+|alanine--tRNA-ligase
MPSALTASQIREAFLQFFEERAHRRVASSSLVPVGDQTLLFTNAGMVQFKDVFTGREQRDYRRATTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKADAISFAWEFVTKRLGLSTDRLAVTVFNGENNIPWDEEAFELWAKQGVSRDRILKLGYKDNFWAMGDTGPCGPCSEIHYHQGDDIPCVEEAAGRKCQGVACDCDRWLEIWNLVFMQFERKEKDAPLIPLPKPSIDTGAGLERIASVVQGKRSNYDTDLFQGILATVSQLCGKPYTQETGASQRVVADHARATAFLVADGVQPSNVARGYVLRRIMRRAIRHGDQQLGIKEPFFFKVVDRVIELMGDAFPELRDGRTFILEVAKHEEEGFRRTLDRGLKLMDEELAKLQASGGKMISGDVVYLLHGTYGFPWDLTQIIARERGYDVDLEGFKKLQEEEAAKQDFHGEKKSTTDIFQDVLARTAPTQFLGYDGEGHEGEGSVLALVQDGVEVPQVSAGATVDVVLDRTPFYGESGGQLGDTGRIVAHGGKTVVQVKDAQRPVQGLIVHSVEVKEGTLKVGDMVQTSVDVERRKSIRANHSATHLLHKALKRVLGEHVKQAGSVVAPDFLRFDFSHFSPATQEQLEQVEDLVNTWVRDNADAQTRVMNIDDAKKSGAVAMFGEKYGETVRVVTVHPESTELCGGTHVKRSGDIGLFKVTSESGVASGVRRIVAVTGVGALQFVREQEHELKKVAALLRTNPKEVAVRVEATQKRVKELERKVEEVSVKAQSASQKDLLDQAREVNGMKVLATRVDPADDKVFRGMADQLRDRIGSGVIAIGGEKDGRAVILVAATKDVVAKGISAGNLVREMAKEVGGKGGGKPDMAQAGGPDADKLPVALEKLFELVKGASPA
>NC_017030.1|WP_014399099.1|7943358_7943916_-|hypothetical-protein
MRMDRRSFWLLDAVVELSENLAVLRSPDLELITNRRTHGLEARELAPMLASLCEAGLIWVKHLETDALARTLPEIESALAVSSCTPGRYSGFWYGLTPEGGAVWESLARPDWSRYSTGWSDGEEHFIEAGARELAEEEFARASSRPSRVLVPGSAVWTVMRPWSATYWKTMPVGFQVRYRSTRGK
>NC_017030.1|WP_014399098.1|7942169_7943228_-|alpha/beta-fold-hydrolase
MVQVTRPSSLTPSTQTRVAPEAPARAKGAQGFNAIVKGDSFSAVAPVGSQQVNALRLPIPWPGKGEADKIGWIQKAYPPAKDSTAEFMKLNQAVRAGQNVMPPEAKNCVFLAVGGLLSEAAPKQFYFDKNLDALEAQGLQVGRVPVDTDMGVEHNAAIVRQAVLEASKNGKQVVLIGHSKGGLDSAAALSMYPELQEHVRALVTIQSPYGGSPMAQDLLDNPLVRYGVGGAVEALGGSIQAGEDLTYDSRKEFLAKHPMPPGIPTVSMASTTANPTSPLFAMQEYMHQRYGVKSDGLVLPQDAFIPGSKSVTLSGLDHLDSTGTTLNPFKPYQPEDLTLSLVAMALKMPKGG
>NC_017030.1|WP_014399097.1|7941354_7942125_+|hypothetical-protein
MTTIASVVVGGKVSRSPNAQDSRMTFAAQIAAYCRGRGAKIVLLPAGYLFSADAEETPRTSAKALAKVFSGLCLIAGIDSADAEKLESSKAQNGKRLDKWTRNESLPFWVFASDSSGKVLTLFRQRSTTSSNGKAAGQPSPAEQQHRTVKLAGLQCYLLACGELFNPFLRPLLEQEQGFALIAHLGHKGLGRTFPKSFPALANATGAWVINAQHTWSGECWAAEPGKKARRIPGDVIHETTHSSGEWARVAFWDVP
>NC_017030.1|WP_014399096.1|7941022_7941187_-|hypothetical-protein
MNKKPNHPSDIRNGNWGTPGTNATWDKAQGNRGKQLNPNARPRPKSGRPQGKKK
>NC_017030.1|WP_148282390.1|7939901_7940951_-|hypothetical-protein
MAEPKPRKPKFKYTRELVKIALADGMTQKEVGDLCRVEQSVVSGWFNGKSLALEHQVAELKKRYGHRLNRTTSRVYLVRAQRTSDERWEESALGQRLLALRERLERESAASIRRRGPKPMGGVVEVQSPDDARPESLKASQEELRELQVDILEEEHPSAGVDVLIEIDRRDFEAARRPIQLTQVEGPVVFRYTFVQLVPVVRKMVELARVPVARWLVHRHLDGRFVLVQQKRRILTGRARWAWLKTLKSLHQEARERFRHGTQGIDPRFTHLADEEPFVECADDSARWLSVIHGPFDSNALLAHSEVFFAGPGRALDAHDVLTLPFLLRKMLVEHGHDVPGVVRILSSE
>NC_017030.1|WP_014399094.1|7939156_7939594_+|serine-acetyltransferase
MGPTALTFYRAAKRLQAHPRLANVVATVGDRIHNSHVDTKAVLHPTVELGYGGIGVIIAPGVEIGENSFISQNVSLEPLPGVDGVPRVGRDVYIGVGAQVLGPVVIGDGAKIGANAIVMEDVAPGATVAGIPARELKRQAPPTGT
>NC_017030.1|WP_014399093.1|7937981_7939175_+|GNAT-family-N-acetyltransferase
MEESPITDAVLGERVPSLPRLKAVEPVARGRVEPLCVAEVRSLAAFNALEAEWNALVKRVDDQVFYRHEFVRCWIENFAPGAALRILTARNALGMLVAVLGLQEEQGHQYGVPVRQLSSLTNKHSCRFDLVAEEPKRAAVAFLSHLMGDPSWEVLRLSDVPEGGAAWELLNAARGAGMPWGAWPSARSPYLVLPSTVAAWTKGRSNAKPLRRRRRRLEERGRVEVERVAEVEGLGSKLEEAFALEQSGWKAQEGTAIAQAEHRRGFYTGLARTAAERGWLGLYFLRLDSRPIAFQYGLEYAGRYLAMKPGYDESLAEVSPGHLLTENLIQDCIGRGLGELDLLGDDAPYKREWTEQVRQHHWLFIYRDTWMGQTLQRSKFRWAPVAKRMVGRWVRRR
>NC_017030.1|WP_148282389.1|7933338_7937946_+|hypothetical-protein
MNSSGRDMHLANEPLESQLLEALPPLHRRVRGAQVEVLAQRLVESCPRPAGLEGLAPWLGVALEALETELAAVHAEIVQFTRQHNEALDDAARRQVLVEHIKATVKDRKDRKEDLRALDRWMGFDALRERLEKRRHKLLIEEETALRALTGVLGKAHAQELQPAAVPLARQLLDRAVDAPRAQNRSAALEAFRQLAQTVPGVAASLPEVGPTLTSLAGQEDVSPFFQAEALRALLTVDVLEGITLLRQRLRAKAPSEKDFLFRRQVLEQCAPLLSEEHRMPLLTEVAHHDPSEYVRMGLCALIAQRQDGQPLLRRLAGLEQVPAVAGQTLSEPSPRVRTAAVLAAVDAALTAPKVKGPALQVLVDVIGRDTAPLVLRVSCERAAALAEALGAAGLGPAHAALLDAVESLATQPGATGPVVEAAAAAAQVLHRVKDPVRQAWTAFLAGRVSKLRPGSRTRIPLQPAPENLPPMPEGPAWLGAILADLSQDGHGLYAERTDKTLTLWHGDRQERRLWRMWHELGRPAPNKRQAFLHTTGRVMSGTLRAHPGHLDEITETLVPGERVHVASQGSWGRHLPTVDDLLDMPLSKDGKVHLFSSHGETVLVPPASRLRRLTNRLKVSKDYRRLASLRLDSLGGEEPRERRRFVEQVERELGVQVRFTPYGQHKQVPAPLATLFHEPEAAPKPTSTLHTPAVLGLQSGFLALLTERIMENEGYFLGMGGNGIAALGLFTAALFSIFLGDTYVKRQSVRKSREKIPLVIGGWGTRGKSGTERLKAALFSGMGFEVFAKTTGSEAMFVHSAPGAGPSEFFIFRPYDKATIWEQKDMVELGARLGTEVFLWECMALQPNFVELLQNDWMRDDFATLTNAYPDHEDIQGPAGINVASVITNFMPNGGRVVTTEDHFLPLFKQAAKEKDTTLLHSAWWEAELIPEEFLALFPYREHPRNMALVATLAEQLGVSRPYALALMAEHVQPEIGVLKVFPPAKVRGRQLQFINGHSANERTGFMNNWIRTGLGDVDPDANPERAVITVINNRWDRVSRSEVFARIMVEDAPADRHVLIGTNLEGLQKYVRDALDRHLLSTEVVAAEEVSSPEGQARAEARLAKELAKLKVPRPTTATFMNRLERYAAGAGLQATATLALTAAVEKALEGGDDDVGVEKVRRALEREVGPLIDEALSPASRAQPSSLPEVLTAATQDEVREHALYLLARMAVHARLKALLPRGEADAQGRVKAFHAKFRDAYKAMMLEQLVPVSDSQATGDQVVDACARSVAPGMQVSIMGAQNIKGTGLDWVYRWMALDRVTTALKALEGTSVEARRRALESLETFDDSGFVDAGLARTVLPGLVSKAASPDEADRLRKLAERSRARHELKIAALTHTAAGGATQVVVRKLEKVFDYLDSVTRRRLSELLLEDLETGRVSHARAAVETRKLYERQKGGWLFRGLKKQPKLAPVPTVEAPTPVMPAPAEAVFKTTVELPSTKVPVQVRHVPLDTNALTKLEGPVLLRDEPLKKQGPDVLGPEVADDAGEPLS
>NC_017030.1|WP_014399103.1|7952648_7953272_+|outer-membrane-beta-barrel-protein
MRRTSMVAGLVVAGTCVAGPALAVDASEVSRKLSFSEEDATAGLDVGAGLGGFTGDLGDETGVGGLFNITANAQPWKYIGVEVGYEGQNIPIDDARVLGGNNIFRNNGTFMGQLGPIVDHKWHPFVGLGVGLSYLHVSSGAEDVYNNDWQTEVPLAAGIEYRLGHLSAGVRATYRIVGGEGLFEVPGTTDDAKGSLFNGNVTVGGRF
>NC_017030.1|WP_014399104.1|7953321_7954659_-|glutamate--cysteine-ligase
MSLDLKRVASEPLTSAAPLVEELRKGEKPRTQHRLGLEHEKFIYPVGSAQPPPYEGPNGIGALLERIAPGGYDRFRETPESPVIALQRGMAAISLEPGGQFELSGSPFRTAREAHQENLEHLKETKAAASALGLRLVALGYRPVGTTGEMPWMPKTRYQVMRRTLPERGRLALNMMLMTSTGQVSLDWADEADCVRKTVAVARLSPLLVALYANSPLLEGKPSGYMSFRSRVWEEVDPTRCGYLPSWFDGSFSYQAYVDWALDAPLLFLRREGEYRHPKLTFRQLMKEGYEGKPPDMGDWTDHLSTLFPEVRLKKVLEVRGADCSSAAMTGALGALWRGILYDAQALEEAELLLPRLTFTEHLAFHDTARREGLAGKLGPRELHRLAGEMVAIAKRGLQRLDPEDAPLLAPLEAVAASGRSPAQAVLDAWKEDPRPEVLMSRFEL
>NC_017030.1|WP_014399105.1|7954718_7955540_+|EI24-domain-containing-protein
MRPASPVPTLSPRPRLSDFLQGMGVLGRAFKLIFRSRRLFLLSSLCAVLTAIALVGLAVLLYRYAPGLLESVWARPDSWYGQAGWYTALVLGSLVAWVVGANVVPPLLLTPLQDPVSEATEAECAGADAVLSPASFLRGLTTGLLHTLARMALLFLGLAVLLPLNFVPGLGSVAFTVLASLWTMLWMAAEHLAAPMTRHLYPFAEVRRMLRERRALCLGFGAGVYLLLWVPILNTFFLPVAIVGGTLLYRALREAGDLPPPPDAQADARADAK
>NC_017030.1|WP_043322036.1|7955757_7959003_+|PDZ-domain-containing-protein
MNRMPRIFRRITAVAVLCGAWAFAGSDRAPLPLTVGAAEAGQDSWDGALPSAGKSEKAPHDLNSLRVLTKVILYVKENYVDPKRVKPKEMMIASLEYVEKSVPDVLVDGNPETGKLNVNVNGKQKEFDISHVDSLWKMSFALKDVFDFLSKNMRPIEETRDIEYAAVNGMLSTLDPHSVLLRPELYREMKLSTKGEFGGLGFVIQMKEGNLTVVKVLPKTPASRAGIQKDDRIKKIGEESTVNMDLNEAVSKLRGPVDSRITITVERDGWDKPRNMTVARAMISIESVQHKLLAGGVGYVRLKNFQGNTTRDLEAALTDIRKQAEAKGGFKGLVLDLRGNPGGLLEQAIQVSDTFLSKGTLVATVGFSDKLREEKRARPADGEENYPIAVLVNAGSASASEIVAGALKNLDRAVIIGRQTFGKGSVQVLYDFPDDSALKLTIAKYLTPGDVSIQEVGIVPDIQLVPTRVTADRVDVFAPRKSMGEADLDQHFGNPESSTVAKKREEVLDREKPGTSLKYLKVDEKAAQASAKKEEPKEKVAAKPGTKDKKEHGQNDPLLDVDVAGQGEDLDDQLDAESQEEIKEDFEVQFARDFVLKVPALKRSEQLAKGKQFVEQKRNEEEQRINNAIAALGLDWSPGPTPKNVQLDASFSPGADTKIIAGEQLDMVINVENKGTEPLKRVRGWTESDNAFLDRREFLFGAIAPGEKKSWKVQVRLPKDLTSRRDDVKVKLFDDNGALRDTLVSELSFVELPRPTFAFNWQVVDDCAECNGDGVVQRGEDVTVVMDVTNTGVGPALDSFAQIKNGGDANIFIEKGRFKLGEIKPGETKTARFQVSLKKAFKGDTFPLKLAILDEPLEEFVLEKLQLPVKDGPVAPLEAKKGLVKLNDKAELFASPTADARPVAKLPQGATLALEATTKGYYKVALEKDRFAFVRTQDAKEVKTGKAQAPKTVAYTTTHQPPDIKLDVDPSHGGVVVNGDKFTLSGMVKDPNGLLDVYVLVNDQKVYFKAVDPKGGEPHTLKFTSDFTLKEGNNNVLVVARESTEFASRRTLVIRRRPAEVAQKVATPAATATTPVKPRQQ
>NC_017030.1|WP_014399107.1|7959194_7960103_+|hypothetical-protein
MRTFSRWLVLATALSGAAAHADANDLVISRFGVERRGSSSVITNTEFAEASADFRAFARTYGAVMTSANLMPPRTTGHSGFAFNAELSVVSLPEDVQLPTEAEQPGSVLVPSLHVRKGLPFSLELGGRVGWIEKSSMVTATGELKWAVNEGFTYLPDVGVRLHVTKLFGAQDLDLTTTGLDIGVGKQFPLGGMVTVTPYGGLDLNFVSATTRTLDFDPSRSPADAAGNDSRDALTNTAPYSRVNAGDNLTPRFYAGARFIGGVLQLGAEISLTNLGSFDQEGAGSRDLPSVFAFNTTLGLDF
>NC_017030.1|WP_014399108.1|7960103_7960820_-|glycerophosphoryl-diester-phosphodiesterase
MLLLAHRGASADAPENTLEAFAEAVRQGADGVELDAMVCGSGEVVVCHDERLDRLAGQPWEVRTTPWWKLSRADVGTPLGFAPARIPLLEEVLDALPEHFLVNIELKCDRFDDGGLAAGVARLLRERDLSGRVVVSSFNPLCLFRLAEVAPTLRRGFLIDPDKPWALQAYALSPLVSSHSVHPFHEACTPERVTAWNDAGLRVAAWTVDDPRRARELRDLGVSYLITNRPGRVREALR
>NC_017030.1|WP_043322039.1|7960939_7961164_+|twin-arginine-translocase-TatA/TatE-family-subunit
MLGTGEFLVLGFILLVVFSAARMGQLGNAVGKFVYSFRKASRGEDLVDVKHLPHSRRGTTDADYTEGSSKDRRS
>NC_017030.1|WP_014399110.1|7961160_7961952_-|hypothetical-protein
MSTLEEARVLARNLHALGGGATVRRKAAARELARREPFDTNELIGHLLSLSRAGQAPATCVLSDFLAALDQEAEHIPHVEALRRMAHVQSLEAVADLFAQGPARKELDADAAARADAQAANQSLGHLKQQARLTRDPDVLSRLATVSNPAVLRNVLINPRLTEDLVVRIAARRPARPEPLVEIWKSPRWSVRHKVRRALAFNPYLPPEVGAKLVPLLSTADLRELVEDAGLLPALRQQAARLLLAPAPGSPPGPLVLPTGEEF
>NC_017030.1|WP_014399111.1|7961958_7964034_-|zinc-ribbon-domain-containing-protein
MIVQCEQCQTRFKIPDEKVTEKGVKVRCTKCQNTFRVAREPAPALSAPPPAGPPAGQADPFQAFGDAPEPTGEVTRPGAAYYAPGAPAVRSQVQSWGDVDVDIDVDAPQAAPGRAPVAPGAAGAMMPFDPPTSSPGVASRRQAAPPPPPPNPALPDLDDPFADFMLDGPAPSAPVAAPRPAVAAPPVAAPRPVPPGAFAPPAARAAPPGAFAVGNAGAARPAAVAPPSGPGAFAAQSAPLGAAAPMGPVPPGAVAPAPPGRAAMPPGPGAALAGAPSGAAPSRAAMPPAGAPVARVPLASVPAGASRPGAAPVASPGLAAAGSTDLAPDPLFDFPIDAPAAPDAASLRHAANVAAAPSPSGAAAVGPSVPSPGFESEDPFASIDTAAPSPDLSAAPEDAHVGPEPMSDLFDFSGAGASGEEGMVASDTGRAALLGDVPAEAGAEEPGGISLLSDVPAYDDGDPFKITTPRREVVDLASMRSGPAVTVAKPSARIEDVGMPQRRMPGRARKLTGVVLNLAIATALVVALGVLGAMYLRDGKVDPSTLSPDRLRTLVMPASRPFIASDVSNGLYETRDGRMLFVVRGEAENRTGAAAAVRVRAALFDGDQRVRSTEGLAGALATPEELHAVTTREAATALRQRMDAASLPVPPGGKVPFLVLFQEFPADLTGHRLEVTLEPIPSEPTADRTGG
>NC_017030.1|WP_014399112.1|7964202_7964883_+|polyhydroxyalkanoate-synthesis-regulator-DNA-binding-domain-containing-protein
MSEAEQANAPSNTKEPKIIKRYTNRKLYDTVESRYVTLDEIAAMIKEGTEVRIVDNRTKEDLTSVTLAQIIFEEEKKKNQMPLSVLREIIRHPGESISGFIQKEVSPRVASIREEAEQRLDKLLRREDGSPQEAPPAEAPDAAAPAPQAEGNAASLNPAELLKASQRAFEDFQRRIDERVKQVVENLTGNLPALGRDMQALSQRLEELEKKLDAVEKGDKKDPSAS

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Crispr_ID: NC_017030_35

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_35

8067497-8067591

Unclear

Consensus_repeat	Method
CCCCGCCGCCGGTTGGGAAGAGCCCG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NC_017030_35

>merge|NC_017030|35|8067497-8067591|CRISPRCasFinder
CCCCGCCGCCGGTTGGGAAGAGCCCGTCGCCGAGGAAGAGGTCTCCCTCACCGACATCACCGCCCCCACCCCGTCCGCCGGTTGGGAAGAGCCCG

>NC_017030|35|25|8067497-8067591|CRISPRCasFinder
CCCCGCCGCCGGTTGGGAAGAGCCCG	TCGCCGAGGAAGAGGTCTCCCTCACCGACATCACCGCCCCCAC
CCCGTCCGCCGGTTGGGAAGAGCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014399183.1\|8054256_8055381_-\|RNA-polymerase-factor-sigma-32	unknown	unknown	gnl\|CDD\|274107
NC_017030.1\|WP_014399198.1\|8075148_8075826_-\|2-hydroxychromene-2-carboxylate-isomerase	unknown	unknown	gnl\|CDD\|239320
NC_017030.1\|WP_014399191.1\|8069045_8069921_-\|dioxygenase	unknown	unknown	gnl\|CDD\|153375
NC_017030.1\|WP_014399195.1\|8072957_8073173_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399188.1\|8061038_8062400_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|290220
NC_017030.1\|WP_014399182.1\|8053587_8054151_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_043322062.1\|8063020_8063626_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NC_017030.1\|WP_014399184.1\|8055449_8057867_+\|DEAD/DEAH-box-helicase	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|223587
NC_017030.1\|WP_014399180.1\|8050484_8051960_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371989
NC_017030.1\|WP_014399190.1\|8068381_8069011_-\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NC_017030.1\|WP_014399193.1\|8071708_8072440_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NC_017030.1\|WP_043324120.1\|8059768_8060986_+\|threonine-ammonia-lyase	unknown	unknown	gnl\|CDD\|236182
NC_017030.1\|WP_014399196.1\|8073230_8074427_-\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|180261
NC_017030.1\|WP_014399185.1\|8057888_8058383_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NC_017030.1\|WP_014399194.1\|8072570_8072768_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399192.1\|8070066_8071707_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_017030.1\|WP_014399186.1\|8058451_8059681_+\|glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|178095
NC_017030.1\|WP_014399181.1\|8051989_8053555_+\|beta-ketoacyl-synthase	unknown	unknown	gnl\|CDD\|238430
NC_017030.1\|WP_014399197.1\|8074501_8075152_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399199.1\|8075853_8079504_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014399183.1\|8054256_8055381_-\|RNA-polymerase-factor-sigma-32	gnl\|CDD\|274107	TIGR02392, RNA_polymerase_sigma_factor_RpoH, alternative sigma factor RpoH. A sigma factor is a DNA-binding protein protein that binds to the DNA-directed RNA polymerase core to produce the holoenzyme capable of initiating transcription at specific sites. Different sigma factors act in vegetative growth, heat shock, extracytoplasmic functions (ECF), etc. This model represents the clade of sigma factors called RpoH and further restricted to the Proteobacteria. This protein may be called sigma-32, sigma factor H, heat shock sigma factor, and alternative sigma factor RpoH. Note that in some species the single locus rpoH may be replaced by two or more differentially regulated stress response sigma factors. [Cellular processes, Adaptations to atypical conditions, Transcription, Transcription factors].	2.36116e-94
NC_017030.1\|WP_014399198.1\|8075148_8075826_-\|2-hydroxychromene-2-carboxylate-isomerase	gnl\|CDD\|239320	cd03022, DsbA_HCCA_Iso, DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-dihydroxynapthalene by a dioxygenase, into cis-o-hydroxybenzylidenepyruvate (cHBPA). This is the fourth reaction in a six-step pathway that converts napthalene into salicylate. HCCA isomerase is unique to bacteria that degrade polycyclic aromatic compounds. It is closely related to the eukaryotic protein, GSH transferase kappa (GSTK).	1.52725e-58
NC_017030.1\|WP_014399191.1\|8069045_8069921_-\|dioxygenase	gnl\|CDD\|153375	cd07363, 45_DOPA_Dioxygenase, The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine. This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.	1.12688e-109
NC_017030.1\|WP_014399188.1\|8061038_8062400_+\|hypothetical-protein	gnl\|CDD\|290220	pfam13485, Peptidase_MA_2, Peptidase MA superfamily.	5.5601e-07
NC_017030.1\|WP_043322062.1\|8063020_8063626_-\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	9.35746e-05
NC_017030.1\|WP_014399184.1\|8055449_8057867_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	7.17127e-138
NC_017030.1\|WP_014399180.1\|8050484_8051960_+\|hypothetical-protein	gnl\|CDD\|371989	pfam12248, Methyltransf_FA, Farnesoic acid 0-methyl transferase. This domain family is found in bacteria and eukaryotes, and is approximately 110 amino acids in length.Farnesoic acid O-methyl transferase (FAMeT) is the enzyme that catalyzes the formation of methyl farnesoate (MF) from farnesoic acid (FA) in the biosynthetic pathway of juvenile hormone (JH).	3.61086e-06
NC_017030.1\|WP_014399190.1\|8068381_8069011_-\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	4.47441e-62
NC_017030.1\|WP_014399193.1\|8071708_8072440_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	7.73116e-07
NC_017030.1\|WP_043324120.1\|8059768_8060986_+\|threonine-ammonia-lyase	gnl\|CDD\|236182	PRK08198, PRK08198, threonine dehydratase; Provisional.	0
NC_017030.1\|WP_014399185.1\|8057888_8058383_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.14928e-16
NC_017030.1\|WP_014399196.1\|8073230_8074427_-\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NC_017030.1\|WP_014399192.1\|8070066_8071707_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	3.70485e-144
NC_017030.1\|WP_014399186.1\|8058451_8059681_+\|glutamate-dehydrogenase	gnl\|CDD\|178095	PLN02477, PLN02477, glutamate dehydrogenase.	0
NC_017030.1\|WP_014399181.1\|8051989_8053555_+\|beta-ketoacyl-synthase	gnl\|CDD\|238430	cd00834, KAS_I_II, Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.	3.7272e-38
NC_017030.1\|WP_014399199.1\|8075853_8079504_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.78785e-71

>NC_017030.1|WP_043322062.1|8063020_8063626_-|hypothetical-protein
MAAACVSCTAASTGAAGSAVATSLQSHSEAAPSAGAVGSTASGAESSALARDSSDSTASGAASHAASTGDRSSAITASATGSASSNSASPTACSAEASASAIGSSPDAAGAWASDSTSIDRSANESSSEGSGAAASTGGGVSVDSPEKSSSALVPHGSAAAAGEVATGACGIHGAGSLSEGMSMSSVLRFRLSGSEGACGA
>NC_017030.1|WP_014399188.1|8061038_8062400_+|hypothetical-protein
MNTPLIALLLLAAAPPAQKAKELAAHKEWEELYLAFAAADPASYPEAQRPSVAAPLLKGCEALLAEDAVMAYSLGERAVAFQETAGGLRCLAKSALKTDQRAAAEEALKKGLATFPKDGAFALELGRLQLQDKDSAGALATLQQVPAKSKEAAEAKKLMQQARAQVSEEGAARREAERLEQRMNGDGDTRQAKATAGGEVRPASLSYESGVGKDGMRVRQNSRFAIRYFNSDRDFGQRAEYEGKVVSALDEAYDFTQRTLGRARERQLNVVLYTRDEFATHLGPSYAARVAGLYHDDAIRMNDAAELTQGTKATLVHEYVHAAVDEICPRGGGALPRWFNEGLAEYIEWRYLGLDGPPRYLRDVMKGQAKQGRLPKLSDMDSQAPISMSQPEVAYGTSAMAVRELVRLGGQEKLLDFIQKAGQAESFQEALKATYEKDFAGLDQAVRAALSGR
>NC_017030.1|WP_043324120.1|8059768_8060986_+|threonine-ammonia-lyase
MVTLQDIQAARERIRPALRPTPCPASDYFTEKTDCAVVYFKLENLQRTGAFKERGALNKLLTLTEEEKRRGVIAASAGNHAQGVAYHARRLGIRATIVMPERTPLIKVTRTRDDYGARVVLKGANYDEAYAEALRIQAAENLVFVHPFNDPHVIAGQGTLALELLEQCPDLELVVVPVGGGGLISGVAVALKETNPRIQVVGVQASTIASMKASLDAGKRTELTNAGTTIADGIAVKVPGELTFEHVRKYVDAMVTVDEEEIAAAILMMLEQEKSVAEGAGAAGLAALVNGRIPQAKGKRVAIIVGGGNIDMNVISRIIERGLVKAGRLVQLEVRLPDRPGMLARLTTQIAEMRANVVDLHHDRAFSKAGLGEATVEVMLETTGHAHIQELMTALESQGWQVART
>NC_017030.1|WP_014399186.1|8058451_8059681_+|glutamate-dehydrogenase
MNAVDGTNYYFRKAARVMDVGTPIETLLATPLREVKVQVSIEMDSGEIRTFLGYRIQHDNSRGPMKGGLRYHPALDQDECVSLASLMTWKTAVVNVPYGGAKGGVACDPAQMSLKEVERLTRKFVDQIQDVIGPTRDIPAPDVNTNPQVMAWVMDQYSRYHGHSPAVVTGKPLELYGSKGREAATGRGLLYVCREILRDLGMPVKGTRFAIQGFGNVGSHIAQLIWGDGGVVVAASDVLGGMYNPTGLDVPSLFEHVKRTGTVTGFSGGTPCRNEDVLAADCEVLIPAALGHVLTRDNANSVRARLVVEGANGPTQPEADDILEKRGIFVVPDILASAGGVTVSYLEWVQNLQHVSWEEDRVNAELEKTMKEAYDRVAQIARSRKVSMRTAAYILAIGRVGKATVLRGI
>NC_017030.1|WP_014399185.1|8057888_8058383_-|helix-turn-helix-domain-containing-protein
MRPHSPDDSDAGSSLQGLARRIRTLRERRGLTQEDFAARCDISVSFVSLLERGERNPSYDTLLQVAAALELPLGELFRLEDAEDAGAHRLVEWVRLKKLGRDDVDRLLAVAEAMFSGGPGASTPPAKEASAACASPECGRPVLARGLCVAHYHRARRKKAPPES
>NC_017030.1|WP_014399184.1|8055449_8057867_+|DEAD/DEAH-box-helicase
MSDIQEPTPGAPAPDEASTRPAEYIADVSFDEMNLSEPLRRALAERGYTSPTPVQAKAFGPAMAGKDLIVRSKTGTGKTAAFGLPLLEKIPADEKRVRALILCPTRELALQVAEELTTLAKYKGVKVAAIYGGASMKQQEDALEEGTPIIVGTPGRVFDHINRGNLKLDGCDHAVLDEADEMLNQGFYEEVTRILDRLPKTRQVLLFSATVPTDIQNLIARYTTNAETLLLSGDVFTVEHIHHIRYDVSDQFPKPRNLIYILEKEEPSNAIIFCNTRDDTALVTAVLNRNGFDAELLNGDLPQKERERVMGKVKRGEVAFMVATDIAARGIDISGLEYVINYSLPEDPAVYLHRVGRTGRIGNKGTAINLFSGRELATFTVLEKKFGIKFEMREMPAPEEAMHLWTERHVRELREGMGSSIFEGFLPLASQLKQRPDADDLIAFLIKYYFSRLRMEKAQAAGETEKREPAPERKPVERRGKDRERDRERPRREDRGERAERPRRDEHPDRERRPRRDERREDRGERRGAGSAALEAGPGETKLWVNLGTADGLGPGSIATAMEDAGAPLGKLVRAELRPTFAYVFVAEEDSAGFEALNGKQHGGKTLRVEKSKPRSERDTTSTRPPPSPDAGPGEVKLWVNLGSDDGMDEAKLPATLESLGAPAGKVIKALTRPTYGYVYVPEDDAAGFESLNGKAHNDKPLKLERHRPRGQREERRPRHEALPDIPGQARLWVGLGRQEGLDEAGVTAALEAAGAPAGKVLRTDLRPTYAYVFVAEEDVAGFEATHGKPHGEGKTLKVERAKRK
>NC_017030.1|WP_014399183.1|8054256_8055381_-|RNA-polymerase-factor-sigma-32
MANGRKRTNGPAAPRPRAKRPAASARPGAARETAPETPEEDVEETAQDPDALEPDLAELNEAEAEIEESPAPARPAALVRAEASSALTNRDPLQAYMAEVTKHPLLTREEEHRLAKEYQSTGDVRAAYRLVASNLRLVVKLAHEYHRNPLSLLDLVQEGNIGLMQAVKKYDPDRGVKLSSYAAWWIRAYILRYIMDNWKMVKLGTTEAQRKLFFKLRQEQEKLISQGFEASPRLLAERLNVSEQDVVEMDQRLGHDEVSIDAPLGNDGDSGATRADRYLPSSAVPADERLGGEQLKALFRENLAAFAQTLEGKERYIFEHRLTADEPLTLQDIGDKYGVSRERARQIEAALINRMREFMRERIPDFDMVAVPKG
>NC_017030.1|WP_014399182.1|8053587_8054151_-|hypothetical-protein
MRHLLRAAPLWALTASVVLVTGCAGHQRDNYVRDRAATAAYEQPLAQLWPEVKAIMDERGYSWRELPNQFVLETEWLDSGGGTLGPTSSTRYLIEGVTLADGRAVLRALRTDRVQQSVGVSYATDKGNGRPSTGGLADENGVGRSASGLAPAQKASYRDLDLELEFFRKLNPKGATALEAEASAKYP
>NC_017030.1|WP_014399181.1|8051989_8053555_+|beta-ketoacyl-synthase
MRRVGIFGWGVVAPRSPNIEAFAKNLASSETWLTPFNGFGPDNFLVGTPEFDLADYKPWIDERFPANRFSQLERKMGQPTQYAIGAFIQSLAQNPGIEKELQELGTKAHVYVGTGLGDLPTIQNISLDLYRAQRRWDRFWASPERNGALRQWRETREPLPGLPPEPSTIEEVERDKAEDDWWHFWAGRSPELREYLEELREIEAIGVPDEGDVESAKLAVIKEKRTRNARLQKKWSAPEPPWNAVSSNVLWNIHNTPASQVSMLGQITGMTFAPVAACSSFGYGLKLAMNAIRLGEAKAVVLGMTDAAPNPLVVGGFYNARVISADAAVSKPLTALRGTHIAGGAVVWVVGDYEHFTQKGFKALGLEPVAVGVTADADHIITPSKEGPTLAIREALGAAGCQPQDVGSWDLHATATPGDFLEVQNLRDVLPESVLITARKGTFGHGMSAGGGWELTAQYLGAESGKVYPTPLSAPELNKQIAKVHGRFVFNQEVAAPEGCSGKLSMGVGGINACVISRPWK
>NC_017030.1|WP_014399180.1|8050484_8051960_+|hypothetical-protein
MGQASRKDKDTQKQEGSPPAASVPSSPDAAQPAVPHEGWRKPAGMSRKGWAILAGAVAFIQLPLIHYALFRGQADVTATVPYQQSFNDPAVVARDFFSTGAYWRVTNGELLGPAPKNNPLWLQASLPDDVAVEFDVRPEYPEGDIRVELFGNGRDPASGYVLVQGGWNNSLSVIARRDINAPALDALQRRAARVAEKGGGQGADLVATGVFKKDTRVRVESRVGAPIQSGRTYHWRIERRGNVLKWAIDGQLVAELDDPFPLKGKGQDRMGLSGWESQLFFDNLRVGTPDSMPATMVAKQEPTLPPGPSEDDFNRDTLGDAWNVTNPAAVKIEDGALVVQNLGNRPVWLKKPLPENAVIEFDAWGDSPDGDMKVEAWGDGRSFYAGDPRLQYTATGYVFIFGGWKNTQSIIARQHEHTNDRAVRDGAAVVPGQRYHFKITRRDGLLSWEVDGKPFLTLQDASPLYGPRNQYFGFSGWQTRVHFDNLKIQPL
>NC_017030.1|WP_014399190.1|8068381_8069011_-|YceI-family-protein
MKMSLKSAITLLAVAAPSFAFASAWEIDSSHSSAQFAVKHMMVSNVRGTFSNVKGNVNLDDKDITKSTIEATLDATTINTNEPKRDEHLKSPDFFDVAKFPTITFKSTKVAKAGKDKLNVTGDLTMHGVTKPVTLAVEGPTPETKDAWGNVRRGAVATTKIKRSDFGLTWNKALEAGGVAVGDEVTITLDLETTKKPDAASAPAATDKK
>NC_017030.1|WP_014399191.1|8069045_8069921_-|dioxygenase
MPTGVDRREVLQGVAAAGVAGVMGPGPSAARQVAPALFVSHGSPMTALDADEYPQALKRFGDGAGAVKALVVVSAHWETDARVHVTAMAAPPLVYDFYGFPEEMYRLRYAPPGAPSLAQDVVARLSSAGVPAVADGERGLDHGVWVPLRHAFPEARVPVLQVALPADATPAQVARMGEALRPLRSEGVLLMGSGGVVHNLRRVNFRNKLASAEPWAAEFDAWVAGKLAARDFLGLQSWMDAPNARVAHPSVEHWLPIYFVLGAALPEDRITPVFEGFHHGTLSMRSFALRA
>NC_017030.1|WP_014399192.1|8070066_8071707_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MAGLEGLDLKELLAFEPKGGVIRFAGQRALLMDPVTLGLLRKELIGMLGMTAARGIFTRLGYAHGWRTAEAMKTAVPWKDEAEWRRSGGRLHTLMGQVRVERIERTAQDGPEPFAEAQWSDSYEAEQHLLHLGQAEEPVCWSLTGFASGYLSYCNGKQIYCAELKCVGKGDAFCHIVGRPEAEWSTECTEFLRFYETQCMEGVLGQVTEALRQAERKLRAKRQSLARVSGVTEDPTGMVARSEAMQRVLNLARRSAKVDTTVLVTGESGVGKERIARLIHDESGRSHKAFIAVNCAAVTESLLESELFGHAKGAFTGATHDRPGLFEAAHGGTLFLDEVGEVPPAMQAKLLRALQEREVRRVGENTSRKVDVRVVAATNRELSEEVRLGRFRQDLFYRLRVIELRIPPLRERREDILPLARLLLAETGERLGRRVNGLSPDAADQLLRYPWPGNVRELGNAVERAVALCEGPRLERDDLPEEVRAAPPSLVPSGNPRRLEDMEKEYILAVLAQNGGNRSRTAEQLDIGVATLYRKLKQYGHPEAAH
>NC_017030.1|WP_014399193.1|8071708_8072440_-|rhomboid-family-intramembrane-serine-protease
MRPMRGYNRGGGGFGDMFPSLDSMAAKLAIAFVGISALFLATSRGQGGLLLLNPADVILRFRVWELVTYAFVATGPLGILFGGLIIWSIGGFLESTWGGKRLLLVAVGIPFVAGLITTALALVMPMSVYAGGSVMTAVMWVAYGLVIGKGQTNFWGIPLTGNWFAAIGAGFTVLNMLTAGSWRAVAPEIFGLVLVFVYVRGASPKRLMLQLQHWRLQRQLRDRSKHLRVVDRNRPPDRDQYLN
>NC_017030.1|WP_014399194.1|8072570_8072768_-|hypothetical-protein
MGVISFTGVKVFSTTLARDRENMGENITKWLKENSSVEVVDKIVTQSSDKEFHCLTITLFYRHKT
>NC_017030.1|WP_014399195.1|8072957_8073173_-|hypothetical-protein
MSNEVDAKTARERAKAIAEQRRAERRNRKRRCVVCGVEESDKTPLTAHPEGIGPACKDEVTCQARRAAAGR
>NC_017030.1|WP_014399196.1|8073230_8074427_-|acetyl-CoA-C-acetyltransferase
MKSVSKNEEIYFLSGKRTPFGTYGGSLKDLSATDLAVESAKAALAQAGVSPELIEHVVYGNVVQTSSDAIYLPRHVGLRTGVPVPVPALGVNRLCGSGFQAFVTAAEMMLTGGAEAVLAGGTESMSQAPHVIRGARWGLPLGKGGLEDMLWTALTDSYTGNAMALTAEQLAVDYSISQDDVDQYAVLTQKRFAAAQEAGRLADEIAPVTLKGKKGDTVVSKDEHNRPETTVEGLRKLPKVFKKDGVVHAGAASGICDGAGSMVMATRGFVEKHGLKPMARLVNWGIAGCDPRIMGIGPAPAIRNLLKRADAKLTDVDLFEVNEAFAPQYLAVEKDLGLPRDATNVNGGAIAVGHPLGASGARITMSLAYELKRRGARYGIGSACIGGGQGIAVLVEAL
>NC_017030.1|WP_014399197.1|8074501_8075152_-|hypothetical-protein
MNVLGQLGVAVAGLVLAGVLLFLNFWRALLYLFPHTVRVEPEAPADQMDLPESLGPLAGQLQALGFTPLGSHEEKPLLQKATRSYDWAHPGERVFATLHEGSDLLPRLYLLTPLASGGFVVTASYRRPALDVPGYRSGSLEDAAPERLLRAHVRRLEGLEPAGPEGFTWEGRVQAARAWYQGLGRKEIRRQNLQGLLWTAIALAIVASAFLGRRAG
>NC_017030.1|WP_014399198.1|8075148_8075826_-|2-hydroxychromene-2-carboxylate-isomerase
MASSPLRFCLDYLSPYAYLAWLRMPAIAQKHGRELEPVPVLLAGLLNAVGSVGPAEIPAKRVYVFKQTFRIAHEQGAPFTLPPSHPFNPLLSLRVTAAVDDVAERTRLTTALYSAAWGQGRGIETPEQVGAVLTEAGFDARALLERAQLPEVKDRLRKNTEAALAQGAFGVPSVLVDDEMFWGVDSLGHLERFLEGRDPLTPADLAKWQHLPATADRRQGGKPRP
>NC_017030.1|WP_014399199.1|8075853_8079504_-|protein-kinase
MRTPITLPGSGIGERRSLIPGVVVTGRYRVESLLGEGGMGRIWLADDLQERRRVALKEMHVPSELSAAKVEELVLLFRHEFFAMKKLQHPSTLKVFDWGMTEAGNRFITMEVVGGNDLSTLVRDAPLDTRTLYRVLIQMAQVLAFIHSRLYVHCDIKASNVRITESGAVKLMDFGVMHQLGTPSPGKLKGTLEYLAPEWQRGASIDGRADLYSLGVMAWYLATRKLPFKRNSPAVLLADHLTRPPPRPSTLCPVDPQLEEIILLLMAKDPRERFQDAGELLEALCHASGEPVPEEPLSARASYLHVPEVVGREAELEGLMNGLAEADWGQSRAMLVGGPAGVGKTRLLQEFELQAKLAELPFGRGQCRAEGLSPLAPVAQSLRCLVPHTPADLMERVKAPLARLLSPEVLEGDQDEQLPRDGSDEKAAFFEALTEWTRTLGERQSFVLCLEDLQWADSASLEALNVVIRALHGTRGMVVGTFRSQELSRLSLAFQTVDEKLTSRMDLEPLSAEHVAKLVELVLPGLEMPEGFVPRLHATTGGNAFFATECLRMLVEAGALRRVGGRWEAEEGLGTRRLPASIQEAVLVRLANAPPEQVSLLRKLAPAGRMLDLPLLRALSGLPEAELFAVLDGIVERQFLQDVEGRYVFTHDTVHQAVYDSTPEPARRTYHGQVARTLQALPSGRSGVVRAVGWHFSRSDAPAEAIQPLLEAGQAAIEAEALLEATLLLKEAAGLLESAPDYPGRSEQLLRTWVSLVEVGYSSDPPTSVAYAERLFAHWAATVDVEAGRREALSRLESARVATPAEREELLIPLFREVSAGVRMTPVDVFWKRSELQILQGMALAILGRTEELEALIARVAAEHPEDSPYRAGLSVARSTLCAYTGHWAGGVAEQRKQVQRLHAFRDAVGRPPRRLAWALGMGGYLLNVNLALRGEPLDEALLKDGLLLAEGQGFTDVRAYHLFAQVARAAFTGDGAAFASALAQKTELVRRLGSPRLMERNLALFTPPYYLERGEHELVAAVVSRGEALSRVLPEDRWLRAHVQVYQACRDVLFEDAAAARESLPRALEAARMGGLRMETLVRVYQSRFEREQGRLPAALAAAEAALERALDPRFANPWDEILARRALAPLVSQEEGDAHLRHARLLAESTGNVLQMGLVYMQHAERHGTPEEALRELEIAERAFTTARATHLQQLAQSLRGPLSRQHEDVKQSA

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Crispr_ID: NC_017030_34

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_34

8063924-8064265

Unclear

Consensus_repeat	Method
CGACGTCGCCACGGACTGGCAGGC	PILER-CR

5 spacers

cas3

The CRISPR arrays of NC_017030_34

>merge|NC_017030|34|8063924-8064265|PILER-CR
CGACGTCGCCACGGACTGGCAGGCGGATGGCGAGACTCCGGCGGCCGATGCGATTGCGCTCGGCACGAACGACGTCGCCACGGACTGGCAGGCCGCTGCTGAGACTCCGGCGGAGGAGGTCGCGGTCGCCACGGATTGGCAGACCGGTGGCGAGGCTGGGGCCGATGCGATTGCGCTCGGCACGAACGACGTCGCCACGGACTGGCAGGCAGATGGCGAGGCTGCGGACGCGGTCGCGCTGAGCACCAACGACGTCGCCACGGACTGGCAGGCAGATGGCGAGGCTCCGGCTGCGGACACGGTCGCGCTGAGCACGAACGACGTCGCCACGGACTGGCAGGC

>NC_017030|34|9|8063924-8064265|PILER-CR
CGACGTCGCCACGGACTGGCAGGC	GGATGGCGAGACTCCGGCGGCCGATGCGATTGCGCTCGGCACGAA
CGACGTCGCCACGGACTGGCAGGC	CGCTGCTGAGACTCCGGCGGAGGAGGTCGCG
GTCGCCACGGATTGGCAGACCGGT	GGCGAGGCTGGGGCCGATGCGATTGCGCTCGGCACGAACGAC
GTCGCCACGGACTGGCAGGCAGAT	GGCGAGGCTGCGGACGCGGTCGCGCTGAGCACCAACGAC
GTCGCCACGGACTGGCAGGCAGAT	GGCGAGGCTCCGGCTGCGGACACGGTCGCGCTGAGCACGAACGAC
GTCGCCACGGACTGGCAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014399183.1\|8054256_8055381_-\|RNA-polymerase-factor-sigma-32	unknown	unknown	gnl\|CDD\|274107
NC_017030.1\|WP_014399198.1\|8075148_8075826_-\|2-hydroxychromene-2-carboxylate-isomerase	unknown	unknown	gnl\|CDD\|239320
NC_017030.1\|WP_014399191.1\|8069045_8069921_-\|dioxygenase	unknown	unknown	gnl\|CDD\|153375
NC_017030.1\|WP_043322062.1\|8063020_8063626_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NC_017030.1\|WP_014399188.1\|8061038_8062400_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|290220
NC_017030.1\|WP_014399182.1\|8053587_8054151_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_083892223.1\|8064521_8068277_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_017030.1\|WP_014399184.1\|8055449_8057867_+\|DEAD/DEAH-box-helicase	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|223587
NC_017030.1\|WP_014399180.1\|8050484_8051960_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371989
NC_017030.1\|WP_014399190.1\|8068381_8069011_-\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NC_017030.1\|WP_014399193.1\|8071708_8072440_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NC_017030.1\|WP_043324120.1\|8059768_8060986_+\|threonine-ammonia-lyase	unknown	unknown	gnl\|CDD\|236182
NC_017030.1\|WP_014399195.1\|8072957_8073173_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399185.1\|8057888_8058383_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NC_017030.1\|WP_014399196.1\|8073230_8074427_-\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|180261
NC_017030.1\|WP_014399194.1\|8072570_8072768_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014399192.1\|8070066_8071707_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_017030.1\|WP_014399186.1\|8058451_8059681_+\|glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|178095
NC_017030.1\|WP_014399181.1\|8051989_8053555_+\|beta-ketoacyl-synthase	unknown	unknown	gnl\|CDD\|238430
NC_017030.1\|WP_014399197.1\|8074501_8075152_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014399183.1\|8054256_8055381_-\|RNA-polymerase-factor-sigma-32	gnl\|CDD\|274107	TIGR02392, RNA_polymerase_sigma_factor_RpoH, alternative sigma factor RpoH. A sigma factor is a DNA-binding protein protein that binds to the DNA-directed RNA polymerase core to produce the holoenzyme capable of initiating transcription at specific sites. Different sigma factors act in vegetative growth, heat shock, extracytoplasmic functions (ECF), etc. This model represents the clade of sigma factors called RpoH and further restricted to the Proteobacteria. This protein may be called sigma-32, sigma factor H, heat shock sigma factor, and alternative sigma factor RpoH. Note that in some species the single locus rpoH may be replaced by two or more differentially regulated stress response sigma factors. [Cellular processes, Adaptations to atypical conditions, Transcription, Transcription factors].	2.36116e-94
NC_017030.1\|WP_014399198.1\|8075148_8075826_-\|2-hydroxychromene-2-carboxylate-isomerase	gnl\|CDD\|239320	cd03022, DsbA_HCCA_Iso, DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-dihydroxynapthalene by a dioxygenase, into cis-o-hydroxybenzylidenepyruvate (cHBPA). This is the fourth reaction in a six-step pathway that converts napthalene into salicylate. HCCA isomerase is unique to bacteria that degrade polycyclic aromatic compounds. It is closely related to the eukaryotic protein, GSH transferase kappa (GSTK).	1.52725e-58
NC_017030.1\|WP_014399191.1\|8069045_8069921_-\|dioxygenase	gnl\|CDD\|153375	cd07363, 45_DOPA_Dioxygenase, The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine. This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.	1.12688e-109
NC_017030.1\|WP_043322062.1\|8063020_8063626_-\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	9.35746e-05
NC_017030.1\|WP_014399188.1\|8061038_8062400_+\|hypothetical-protein	gnl\|CDD\|290220	pfam13485, Peptidase_MA_2, Peptidase MA superfamily.	5.5601e-07
NC_017030.1\|WP_083892223.1\|8064521_8068277_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	8.8686e-13
NC_017030.1\|WP_014399184.1\|8055449_8057867_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	7.17127e-138
NC_017030.1\|WP_014399180.1\|8050484_8051960_+\|hypothetical-protein	gnl\|CDD\|371989	pfam12248, Methyltransf_FA, Farnesoic acid 0-methyl transferase. This domain family is found in bacteria and eukaryotes, and is approximately 110 amino acids in length.Farnesoic acid O-methyl transferase (FAMeT) is the enzyme that catalyzes the formation of methyl farnesoate (MF) from farnesoic acid (FA) in the biosynthetic pathway of juvenile hormone (JH).	3.61086e-06
NC_017030.1\|WP_014399190.1\|8068381_8069011_-\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	4.47441e-62
NC_017030.1\|WP_014399193.1\|8071708_8072440_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	7.73116e-07
NC_017030.1\|WP_043324120.1\|8059768_8060986_+\|threonine-ammonia-lyase	gnl\|CDD\|236182	PRK08198, PRK08198, threonine dehydratase; Provisional.	0
NC_017030.1\|WP_014399185.1\|8057888_8058383_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.14928e-16
NC_017030.1\|WP_014399196.1\|8073230_8074427_-\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NC_017030.1\|WP_014399192.1\|8070066_8071707_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	3.70485e-144
NC_017030.1\|WP_014399186.1\|8058451_8059681_+\|glutamate-dehydrogenase	gnl\|CDD\|178095	PLN02477, PLN02477, glutamate dehydrogenase.	0
NC_017030.1\|WP_014399181.1\|8051989_8053555_+\|beta-ketoacyl-synthase	gnl\|CDD\|238430	cd00834, KAS_I_II, Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.	3.7272e-38

>NC_017030.1|WP_043322062.1|8063020_8063626_-|hypothetical-protein
MAAACVSCTAASTGAAGSAVATSLQSHSEAAPSAGAVGSTASGAESSALARDSSDSTASGAASHAASTGDRSSAITASATGSASSNSASPTACSAEASASAIGSSPDAAGAWASDSTSIDRSANESSSEGSGAAASTGGGVSVDSPEKSSSALVPHGSAAAAGEVATGACGIHGAGSLSEGMSMSSVLRFRLSGSEGACGA
>NC_017030.1|WP_014399188.1|8061038_8062400_+|hypothetical-protein
MNTPLIALLLLAAAPPAQKAKELAAHKEWEELYLAFAAADPASYPEAQRPSVAAPLLKGCEALLAEDAVMAYSLGERAVAFQETAGGLRCLAKSALKTDQRAAAEEALKKGLATFPKDGAFALELGRLQLQDKDSAGALATLQQVPAKSKEAAEAKKLMQQARAQVSEEGAARREAERLEQRMNGDGDTRQAKATAGGEVRPASLSYESGVGKDGMRVRQNSRFAIRYFNSDRDFGQRAEYEGKVVSALDEAYDFTQRTLGRARERQLNVVLYTRDEFATHLGPSYAARVAGLYHDDAIRMNDAAELTQGTKATLVHEYVHAAVDEICPRGGGALPRWFNEGLAEYIEWRYLGLDGPPRYLRDVMKGQAKQGRLPKLSDMDSQAPISMSQPEVAYGTSAMAVRELVRLGGQEKLLDFIQKAGQAESFQEALKATYEKDFAGLDQAVRAALSGR
>NC_017030.1|WP_043324120.1|8059768_8060986_+|threonine-ammonia-lyase
MVTLQDIQAARERIRPALRPTPCPASDYFTEKTDCAVVYFKLENLQRTGAFKERGALNKLLTLTEEEKRRGVIAASAGNHAQGVAYHARRLGIRATIVMPERTPLIKVTRTRDDYGARVVLKGANYDEAYAEALRIQAAENLVFVHPFNDPHVIAGQGTLALELLEQCPDLELVVVPVGGGGLISGVAVALKETNPRIQVVGVQASTIASMKASLDAGKRTELTNAGTTIADGIAVKVPGELTFEHVRKYVDAMVTVDEEEIAAAILMMLEQEKSVAEGAGAAGLAALVNGRIPQAKGKRVAIIVGGGNIDMNVISRIIERGLVKAGRLVQLEVRLPDRPGMLARLTTQIAEMRANVVDLHHDRAFSKAGLGEATVEVMLETTGHAHIQELMTALESQGWQVART
>NC_017030.1|WP_014399186.1|8058451_8059681_+|glutamate-dehydrogenase
MNAVDGTNYYFRKAARVMDVGTPIETLLATPLREVKVQVSIEMDSGEIRTFLGYRIQHDNSRGPMKGGLRYHPALDQDECVSLASLMTWKTAVVNVPYGGAKGGVACDPAQMSLKEVERLTRKFVDQIQDVIGPTRDIPAPDVNTNPQVMAWVMDQYSRYHGHSPAVVTGKPLELYGSKGREAATGRGLLYVCREILRDLGMPVKGTRFAIQGFGNVGSHIAQLIWGDGGVVVAASDVLGGMYNPTGLDVPSLFEHVKRTGTVTGFSGGTPCRNEDVLAADCEVLIPAALGHVLTRDNANSVRARLVVEGANGPTQPEADDILEKRGIFVVPDILASAGGVTVSYLEWVQNLQHVSWEEDRVNAELEKTMKEAYDRVAQIARSRKVSMRTAAYILAIGRVGKATVLRGI
>NC_017030.1|WP_014399185.1|8057888_8058383_-|helix-turn-helix-domain-containing-protein
MRPHSPDDSDAGSSLQGLARRIRTLRERRGLTQEDFAARCDISVSFVSLLERGERNPSYDTLLQVAAALELPLGELFRLEDAEDAGAHRLVEWVRLKKLGRDDVDRLLAVAEAMFSGGPGASTPPAKEASAACASPECGRPVLARGLCVAHYHRARRKKAPPES
>NC_017030.1|WP_014399184.1|8055449_8057867_+|DEAD/DEAH-box-helicase
MSDIQEPTPGAPAPDEASTRPAEYIADVSFDEMNLSEPLRRALAERGYTSPTPVQAKAFGPAMAGKDLIVRSKTGTGKTAAFGLPLLEKIPADEKRVRALILCPTRELALQVAEELTTLAKYKGVKVAAIYGGASMKQQEDALEEGTPIIVGTPGRVFDHINRGNLKLDGCDHAVLDEADEMLNQGFYEEVTRILDRLPKTRQVLLFSATVPTDIQNLIARYTTNAETLLLSGDVFTVEHIHHIRYDVSDQFPKPRNLIYILEKEEPSNAIIFCNTRDDTALVTAVLNRNGFDAELLNGDLPQKERERVMGKVKRGEVAFMVATDIAARGIDISGLEYVINYSLPEDPAVYLHRVGRTGRIGNKGTAINLFSGRELATFTVLEKKFGIKFEMREMPAPEEAMHLWTERHVRELREGMGSSIFEGFLPLASQLKQRPDADDLIAFLIKYYFSRLRMEKAQAAGETEKREPAPERKPVERRGKDRERDRERPRREDRGERAERPRRDEHPDRERRPRRDERREDRGERRGAGSAALEAGPGETKLWVNLGTADGLGPGSIATAMEDAGAPLGKLVRAELRPTFAYVFVAEEDSAGFEALNGKQHGGKTLRVEKSKPRSERDTTSTRPPPSPDAGPGEVKLWVNLGSDDGMDEAKLPATLESLGAPAGKVIKALTRPTYGYVYVPEDDAAGFESLNGKAHNDKPLKLERHRPRGQREERRPRHEALPDIPGQARLWVGLGRQEGLDEAGVTAALEAAGAPAGKVLRTDLRPTYAYVFVAEEDVAGFEATHGKPHGEGKTLKVERAKRK
>NC_017030.1|WP_014399183.1|8054256_8055381_-|RNA-polymerase-factor-sigma-32
MANGRKRTNGPAAPRPRAKRPAASARPGAARETAPETPEEDVEETAQDPDALEPDLAELNEAEAEIEESPAPARPAALVRAEASSALTNRDPLQAYMAEVTKHPLLTREEEHRLAKEYQSTGDVRAAYRLVASNLRLVVKLAHEYHRNPLSLLDLVQEGNIGLMQAVKKYDPDRGVKLSSYAAWWIRAYILRYIMDNWKMVKLGTTEAQRKLFFKLRQEQEKLISQGFEASPRLLAERLNVSEQDVVEMDQRLGHDEVSIDAPLGNDGDSGATRADRYLPSSAVPADERLGGEQLKALFRENLAAFAQTLEGKERYIFEHRLTADEPLTLQDIGDKYGVSRERARQIEAALINRMREFMRERIPDFDMVAVPKG
>NC_017030.1|WP_014399182.1|8053587_8054151_-|hypothetical-protein
MRHLLRAAPLWALTASVVLVTGCAGHQRDNYVRDRAATAAYEQPLAQLWPEVKAIMDERGYSWRELPNQFVLETEWLDSGGGTLGPTSSTRYLIEGVTLADGRAVLRALRTDRVQQSVGVSYATDKGNGRPSTGGLADENGVGRSASGLAPAQKASYRDLDLELEFFRKLNPKGATALEAEASAKYP
>NC_017030.1|WP_014399181.1|8051989_8053555_+|beta-ketoacyl-synthase
MRRVGIFGWGVVAPRSPNIEAFAKNLASSETWLTPFNGFGPDNFLVGTPEFDLADYKPWIDERFPANRFSQLERKMGQPTQYAIGAFIQSLAQNPGIEKELQELGTKAHVYVGTGLGDLPTIQNISLDLYRAQRRWDRFWASPERNGALRQWRETREPLPGLPPEPSTIEEVERDKAEDDWWHFWAGRSPELREYLEELREIEAIGVPDEGDVESAKLAVIKEKRTRNARLQKKWSAPEPPWNAVSSNVLWNIHNTPASQVSMLGQITGMTFAPVAACSSFGYGLKLAMNAIRLGEAKAVVLGMTDAAPNPLVVGGFYNARVISADAAVSKPLTALRGTHIAGGAVVWVVGDYEHFTQKGFKALGLEPVAVGVTADADHIITPSKEGPTLAIREALGAAGCQPQDVGSWDLHATATPGDFLEVQNLRDVLPESVLITARKGTFGHGMSAGGGWELTAQYLGAESGKVYPTPLSAPELNKQIAKVHGRFVFNQEVAAPEGCSGKLSMGVGGINACVISRPWK
>NC_017030.1|WP_014399180.1|8050484_8051960_+|hypothetical-protein
MGQASRKDKDTQKQEGSPPAASVPSSPDAAQPAVPHEGWRKPAGMSRKGWAILAGAVAFIQLPLIHYALFRGQADVTATVPYQQSFNDPAVVARDFFSTGAYWRVTNGELLGPAPKNNPLWLQASLPDDVAVEFDVRPEYPEGDIRVELFGNGRDPASGYVLVQGGWNNSLSVIARRDINAPALDALQRRAARVAEKGGGQGADLVATGVFKKDTRVRVESRVGAPIQSGRTYHWRIERRGNVLKWAIDGQLVAELDDPFPLKGKGQDRMGLSGWESQLFFDNLRVGTPDSMPATMVAKQEPTLPPGPSEDDFNRDTLGDAWNVTNPAAVKIEDGALVVQNLGNRPVWLKKPLPENAVIEFDAWGDSPDGDMKVEAWGDGRSFYAGDPRLQYTATGYVFIFGGWKNTQSIIARQHEHTNDRAVRDGAAVVPGQRYHFKITRRDGLLSWEVDGKPFLTLQDASPLYGPRNQYFGFSGWQTRVHFDNLKIQPL
>NC_017030.1|WP_083892223.1|8064521_8068277_+|hypothetical-protein
MTEWTADSAVATGTPSEEIALDSSEVATDWQSGSATSEQASSEEIALGASDVATEWQADNTAPVQASAEEITLGTDDVATEWQAGAETPAEEIALDANDVAHEGAAEGSVGGAASAVAAGVEAQTFDVADLGAEEEQQLTPPPSPFANESGIPSLRIRSIPVGPDIEADTVELGSDDVEPAAEVAPASEQWSELSGSADDAVPLATAAESLAEAQSTEASAWDTSGQDAQAWSAEGEPSDATTTVGLQDASAAIELQPEWAADAVEPAAPIELQPEWAAEEATAPVAAQSEWAAAEEAPIEAQPEWATEEAAPSTAQAEWGTAEAAPLEAQPEWTAAEGTSTVPTQPQWGTAEAAPIEAQPEWATTEATAPVVAAQSEWTTEEAAPVAAQPEWATEEAAPIEAQPEWATEETAPVSAQSEWATTDATPAAAQPEWATTDSTTEAAPIEAQPEWATEEGAAPVAAQPEWATTEAATQTAPQSEWSATEEAAPIEAQPEWATEEAAPVATQSDWATEEAAAPVAAQPEWAAGEAAPVSAQPEWATEEAAAPVAAQSEWAAEEAPIEAQPEWATEEAAPIEAQPEWATTEATAPVASQPEWATTEAAEPVAAQSEWATEEAAPIEAQPEWATTEATAPGASQSEWATEEAAPIEAQPEWATTEATAPVASQPEWATEEAAPVTAQPEWATEEAAPIEAQPEWATTEATAPVAAQSEWASTEAAPVAAQPEWAAAEEAPIEAQPEWATEEAAPVAAQPEWAAAEEAPIEAQPEWATTEAATPVVAQPEWATEEAAPIEAQPEWATTEAAETVAAQPEWAAAEEAPIEAQPEWATTEAATPVAAQPEWATEEAAPIEAQPEWATTEASAPVAAQPEWAAAEEAPIEAQPEWAATEAVTPGADQPWAATDASAQSEWAATEDSSASSAWAQPSTDAQQPWDAPVEEAAPEWNAAPATPEWGAPEAPAARSAWAAPQEAQPEWMADAAPAASTWQAPPAPAAGWEEPVAEEEVSLTDITAPTPSAGWEEPAVDVDTELDATPALDVEEVDSEPVADIELVEEVPALPVAAIPPPPPPAPALSLSAAPALPVARLTPAAPTSPTLRSPAPVAANHLRPTDDSLFEAPVAGFASAANSFVEGEHRVIIHTVEGQVKRGTIRDADLLEDTISLEQQSGFAPERIPGKRVKAIFFMLAAGARQPQAEGSKIRVTFNDGRQVAGFSQDFKGPTPGFFVIPADTRTNTARIFIYRASVQAVAEG
>NC_017030.1|WP_014399190.1|8068381_8069011_-|YceI-family-protein
MKMSLKSAITLLAVAAPSFAFASAWEIDSSHSSAQFAVKHMMVSNVRGTFSNVKGNVNLDDKDITKSTIEATLDATTINTNEPKRDEHLKSPDFFDVAKFPTITFKSTKVAKAGKDKLNVTGDLTMHGVTKPVTLAVEGPTPETKDAWGNVRRGAVATTKIKRSDFGLTWNKALEAGGVAVGDEVTITLDLETTKKPDAASAPAATDKK
>NC_017030.1|WP_014399191.1|8069045_8069921_-|dioxygenase
MPTGVDRREVLQGVAAAGVAGVMGPGPSAARQVAPALFVSHGSPMTALDADEYPQALKRFGDGAGAVKALVVVSAHWETDARVHVTAMAAPPLVYDFYGFPEEMYRLRYAPPGAPSLAQDVVARLSSAGVPAVADGERGLDHGVWVPLRHAFPEARVPVLQVALPADATPAQVARMGEALRPLRSEGVLLMGSGGVVHNLRRVNFRNKLASAEPWAAEFDAWVAGKLAARDFLGLQSWMDAPNARVAHPSVEHWLPIYFVLGAALPEDRITPVFEGFHHGTLSMRSFALRA
>NC_017030.1|WP_014399192.1|8070066_8071707_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MAGLEGLDLKELLAFEPKGGVIRFAGQRALLMDPVTLGLLRKELIGMLGMTAARGIFTRLGYAHGWRTAEAMKTAVPWKDEAEWRRSGGRLHTLMGQVRVERIERTAQDGPEPFAEAQWSDSYEAEQHLLHLGQAEEPVCWSLTGFASGYLSYCNGKQIYCAELKCVGKGDAFCHIVGRPEAEWSTECTEFLRFYETQCMEGVLGQVTEALRQAERKLRAKRQSLARVSGVTEDPTGMVARSEAMQRVLNLARRSAKVDTTVLVTGESGVGKERIARLIHDESGRSHKAFIAVNCAAVTESLLESELFGHAKGAFTGATHDRPGLFEAAHGGTLFLDEVGEVPPAMQAKLLRALQEREVRRVGENTSRKVDVRVVAATNRELSEEVRLGRFRQDLFYRLRVIELRIPPLRERREDILPLARLLLAETGERLGRRVNGLSPDAADQLLRYPWPGNVRELGNAVERAVALCEGPRLERDDLPEEVRAAPPSLVPSGNPRRLEDMEKEYILAVLAQNGGNRSRTAEQLDIGVATLYRKLKQYGHPEAAH
>NC_017030.1|WP_014399193.1|8071708_8072440_-|rhomboid-family-intramembrane-serine-protease
MRPMRGYNRGGGGFGDMFPSLDSMAAKLAIAFVGISALFLATSRGQGGLLLLNPADVILRFRVWELVTYAFVATGPLGILFGGLIIWSIGGFLESTWGGKRLLLVAVGIPFVAGLITTALALVMPMSVYAGGSVMTAVMWVAYGLVIGKGQTNFWGIPLTGNWFAAIGAGFTVLNMLTAGSWRAVAPEIFGLVLVFVYVRGASPKRLMLQLQHWRLQRQLRDRSKHLRVVDRNRPPDRDQYLN
>NC_017030.1|WP_014399194.1|8072570_8072768_-|hypothetical-protein
MGVISFTGVKVFSTTLARDRENMGENITKWLKENSSVEVVDKIVTQSSDKEFHCLTITLFYRHKT
>NC_017030.1|WP_014399195.1|8072957_8073173_-|hypothetical-protein
MSNEVDAKTARERAKAIAEQRRAERRNRKRRCVVCGVEESDKTPLTAHPEGIGPACKDEVTCQARRAAAGR
>NC_017030.1|WP_014399196.1|8073230_8074427_-|acetyl-CoA-C-acetyltransferase
MKSVSKNEEIYFLSGKRTPFGTYGGSLKDLSATDLAVESAKAALAQAGVSPELIEHVVYGNVVQTSSDAIYLPRHVGLRTGVPVPVPALGVNRLCGSGFQAFVTAAEMMLTGGAEAVLAGGTESMSQAPHVIRGARWGLPLGKGGLEDMLWTALTDSYTGNAMALTAEQLAVDYSISQDDVDQYAVLTQKRFAAAQEAGRLADEIAPVTLKGKKGDTVVSKDEHNRPETTVEGLRKLPKVFKKDGVVHAGAASGICDGAGSMVMATRGFVEKHGLKPMARLVNWGIAGCDPRIMGIGPAPAIRNLLKRADAKLTDVDLFEVNEAFAPQYLAVEKDLGLPRDATNVNGGAIAVGHPLGASGARITMSLAYELKRRGARYGIGSACIGGGQGIAVLVEAL
>NC_017030.1|WP_014399197.1|8074501_8075152_-|hypothetical-protein
MNVLGQLGVAVAGLVLAGVLLFLNFWRALLYLFPHTVRVEPEAPADQMDLPESLGPLAGQLQALGFTPLGSHEEKPLLQKATRSYDWAHPGERVFATLHEGSDLLPRLYLLTPLASGGFVVTASYRRPALDVPGYRSGSLEDAAPERLLRAHVRRLEGLEPAGPEGFTWEGRVQAARAWYQGLGRKEIRRQNLQGLLWTAIALAIVASAFLGRRAG
>NC_017030.1|WP_014399198.1|8075148_8075826_-|2-hydroxychromene-2-carboxylate-isomerase
MASSPLRFCLDYLSPYAYLAWLRMPAIAQKHGRELEPVPVLLAGLLNAVGSVGPAEIPAKRVYVFKQTFRIAHEQGAPFTLPPSHPFNPLLSLRVTAAVDDVAERTRLTTALYSAAWGQGRGIETPEQVGAVLTEAGFDARALLERAQLPEVKDRLRKNTEAALAQGAFGVPSVLVDDEMFWGVDSLGHLERFLEGRDPLTPADLAKWQHLPATADRRQGGKPRP

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Crispr_ID: NC_017030_36

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_36

9234412-9234571

Orphan

Consensus_repeat	Method
GCGAAACCTGTCCGACTGTCCGACAG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_017030_36

>merge|NC_017030|36|9234412-9234571|CRISPRCasFinder
GCGAAACCTGTCCGACTGTCCGACAGCTCGGGAGCACCGCTTGGGGCCCCGCGTCATCCAGGCCGCGGCGAAACCTGTCCGACTGTCCGACAGGTTCAGGTCGCACGCTTCGGGACGGTCGCGCCGCCGAACCTCGGAAACCTGTCCGACTGTCCGACAG

>NC_017030|36|26|9234412-9234571|CRISPRCasFinder
GCGAAACCTGTCCGACTGTCCGACAG	CTCGGGAGCACCGCTTGGGGCCCCGCGTCATCCAGGCCGCG
GCGAAACCTGTCCGACTGTCCGACAG	GTTCAGGTCGCACGCTTCGGGACGGTCGCGCCGCCGAACCT
CGGAAACCTGTCCGACTGTCCGACAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014400147.1\|9232620_9233514_-\|NmrA/HSCARG-family-protein	unknown	unknown	gnl\|CDD\|187561
NC_017030.1\|WP_148282432.1\|9239974_9241417_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274511
NC_017030.1\|WP_014400139.1\|9225751_9226480_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_017030.1\|WP_014400148.1\|9233591_9234203_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_017030.1\|WP_014400141.1\|9229020_9230220_+\|carotenoid-1,2-hydratase	unknown	unknown	gnl\|CDD\|227908
NC_017030.1\|WP_014400138.1\|9223407_9225528_-\|response-regulator	unknown	unknown	gnl\|CDD\|223715
NC_017030.1\|WP_167594438.1\|9232340_9232685_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_017030.1\|WP_167594439.1\|9238421_9239654_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400151.1\|9236529_9238014_+\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|198361
NC_017030.1\|WP_014400157.1\|9243521_9243842_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368828
NC_017030.1\|WP_014400158.1\|9243844_9245356_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|130740
NC_017030.1\|WP_014400142.1\|9230221_9230635_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400150.1\|9236078_9236315_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_193352518.1\|9230742_9231165_+\|DUF3574-domain-containing-protein	unknown	unknown	gnl\|CDD\|371896
NC_017030.1\|WP_014400155.1\|9241421_9242897_-\|ammonia-forming-cytochrome-c-nitrite-reductase-subunit-c552	unknown	unknown	gnl\|CDD\|349426
NC_017030.1\|WP_014400149.1\|9234706_9235690_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187539
NC_017030.1\|WP_014400152.1\|9238089_9238401_+\|4a-hydroxytetrahydrobiopterin-dehydratase	unknown	unknown	gnl\|CDD\|376528
NC_017030.1\|WP_014400156.1\|9242893_9243412_-\|cytochrome-c-nitrite-reductase-small-subunit	unknown	unknown	gnl\|CDD\|274453
NC_017030.1\|WP_014400145.1\|9231776_9232178_-\|Dabb-family-protein	unknown	unknown	gnl\|CDD\|369566
NC_017030.1\|WP_014400140.1\|9226476_9229017_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226957

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014400147.1\|9232620_9233514_-\|NmrA/HSCARG-family-protein	gnl\|CDD\|187561	cd05251, NmrA_like_SDR_a, NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs. NmrA and HSCARG like proteins. NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. HSCARG has been identified as a putative NADP-sensing molecule, and redistributes and restructures in response to NADPH/NADP ratios. Like NmrA, it lacks most of the active site residues of the SDR family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Atypical SDRs are distinct from classical SDRs. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.19263e-70
NC_017030.1\|WP_148282432.1\|9239974_9241417_+\|hypothetical-protein	gnl\|CDD\|274511	TIGR03300, assembly_YfgL, outer membrane assembly lipoprotein YfgL. Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking].	0.000192554
NC_017030.1\|WP_014400139.1\|9225751_9226480_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	4.99657e-109
NC_017030.1\|WP_014400148.1\|9233591_9234203_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	6.13638e-11
NC_017030.1\|WP_014400141.1\|9229020_9230220_+\|carotenoid-1,2-hydratase	gnl\|CDD\|227908	COG5621, COG5621, Predicted secreted hydrolase [General function prediction only].	2.32778e-98
NC_017030.1\|WP_014400138.1\|9223407_9225528_-\|response-regulator	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.78802e-61
NC_017030.1\|WP_167594438.1\|9232340_9232685_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.49109e-29
NC_017030.1\|WP_014400157.1\|9243521_9243842_+\|hypothetical-protein	gnl\|CDD\|368828	pfam06291, Lambda_Bor, Bor protein. This family consists of several Bacteriophage lambda Bor and Escherichia coli Iss proteins. Expression of bor significantly increases the survival of the Escherichia coli host cell in animal serum. This property is a well known bacterial virulence determinant indeed, bor and its adjacent sequences are highly homologous to the iss serum resistance locus of the plasmid ColV2-K94, which confers virulence in animals. It has been suggested that lysogeny may generally have a role in bacterial survival in animal hosts, and perhaps in pathogenesis.	0.0014816
NC_017030.1\|WP_014400151.1\|9236529_9238014_+\|glycerol-kinase-GlpK	gnl\|CDD\|198361	cd07786, FGGY_EcGK_like, Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases. This subgroup is composed of mostly bacterial and archaeal glycerol kinases (GK), including the well characterized proteins from Escherichia coli (EcGK), Thermococcus kodakaraensis (TkGK), and Enterococcus casseliflavus (EnGK). GKs contain two large domains separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The high affinity ATP binding site of EcGK is created only by a substrate-induced conformational change, which is initiated by protein-protein interactions through complex formation with enzyme IIAGlc (also known as IIIGlc), the glucose-specific phosphocarrier protein of the phosphotransferase system (PTS). EcGK exists in a dimer-tetramer equilibrium. IIAGlc binds to both EcGK dimer and tetramer, and inhibits the uptake and subsequent metabolism of glycerol and maltose. Another well-known allosteric regulator of EcGK is fructose 1,6-bisphosphate (FBP), which binds to the EcGK tetramer and plays an essential role in the stabilization of the inactive tetrameric form. EcGK requires Mg2+ for its enzymatic activity. Members in this subgroup belong to the FGGY family of carbohydrate kinases.	0
NC_017030.1\|WP_014400158.1\|9243844_9245356_+\|FAD-binding-protein	gnl\|CDD\|130740	TIGR01679, bact_FAD_ox, FAD-linked oxidoreductase. This model represents a family of bacterial oxidoreductases with covalently linked FAD, closely related to two different eukaryotic oxidases, L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae.	3.59024e-13
NC_017030.1\|WP_193352518.1\|9230742_9231165_+\|DUF3574-domain-containing-protein	gnl\|CDD\|371896	pfam12098, DUF3574, Protein of unknown function (DUF3574). This family of proteins is functionally uncharacterized. This protein is found in bacteria and viruses. Proteins in this family are typically between 144 to 163 amino acids in length. This protein has a conserved TPRF sequence motif.	1.90813e-52
NC_017030.1\|WP_014400155.1\|9241421_9242897_-\|ammonia-forming-cytochrome-c-nitrite-reductase-subunit-c552	gnl\|CDD\|349426	cd00548, NrfA-like, cytochrome c nitrite reductase and similar proteins. This family contains cytochrome c nitrite reductase (also known as cytochrome c552, or NrfA) and similar proteins. The pentaheme enzyme NrfA catalyzes the electron reduction of nitrite to ammonia in the nitrogen cycle. This enzyme can also transform nitrogen monoxide and hydroxylamine, two potential bound reaction intermediates, into ammonia. It is a homodimer, with each monomer containing four classical CXXCH type heme-binding sites along with an alternative CXXCK heme-binding motif, which is important for catalysis. This family also includes octaheme nitrite reductase (TvNiR) from the haloalkaliphilic bacterium Thioalkalivibrio paradoxus which catalyzes the reduction of nitrite and hydroxylamine to ammonia as well as the reduction of sulfite to sulfide.	0
NC_017030.1\|WP_014400149.1\|9234706_9235690_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187539	cd05228, AR_FR_like_1_SDR_e, uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs. This subgroup contains proteins of unknown function related to aldehyde reductase and flavonoid reductase of the extended SDR-type. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. The related flavonoid reductases act in the NADP-dependent reduction of flavonoids, ketone-containing plant secondary metabolites. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.53164e-90
NC_017030.1\|WP_014400152.1\|9238089_9238401_+\|4a-hydroxytetrahydrobiopterin-dehydratase	gnl\|CDD\|376528	pfam01329, Pterin_4a, Pterin 4 alpha carbinolamine dehydratase. Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerization cofactor of hepatocyte nuclear factor 1-alpha).	1.40329e-34
NC_017030.1\|WP_014400156.1\|9242893_9243412_-\|cytochrome-c-nitrite-reductase-small-subunit	gnl\|CDD\|274453	TIGR03153, cytochr_NrfH, cytochrome c nitrite reductase, small subunit. Members of this protein family are NrfH, a tetraheme cytochrome c. NrfH is the cytochrome c nitrite reductase small subunit, and forms a heterodimer with NrfA, the catalytic subunit. While NrfA can act as a monomer, NrfH can bind to and anchor NrfA in the membrane and enables electron transfer to NrfA from quinones. [Energy metabolism, Electron transport].	3.26816e-65
NC_017030.1\|WP_014400145.1\|9231776_9232178_-\|Dabb-family-protein	gnl\|CDD\|369566	pfam07876, Dabb, Stress responsive A/B Barrel Domain. The function of this family is unknown, but it is upregulated in response to salt stress in Populus balsamifera. It is also found at the C-terminus of an fructose 1,6-bisphosphate aldolase from Hydrogenophilus thermoluteolus. Arthrobacter nicotinovorans ORF106 is found in the pA01 plasmid, which encodes genes for molybdopterin uptake and degradation of plant alkaloid nicotine. The structure of one has been solved and the domain forms an a/b barrel dimer. Although there is a clear duplication within the domain it is not obviously detectable in the sequence.	7.75392e-10
NC_017030.1\|WP_014400140.1\|9226476_9229017_+\|ABC-transporter-permease	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	1.39366e-24

>NC_017030.1|WP_014400148.1|9233591_9234203_+|TetR/AcrR-family-transcriptional-regulator
MKKPDKVPVEDATGGAMRADARRNRERLLAAAHAVFSERGADASLNDVAKRAEVGIGTLYRHFESREALLAATCDEQLLTLAKESRERSEALPPLEALRVFLAELVHSAGMYKGLAASLGIVLKSHTAGCDATTAEGQRLLEAAQRAGEVRGDILLDDVVCMAMAISLAAAENSSDPKRIPRLTGMFFDGLRSRPEPRGARHR
>NC_017030.1|WP_014400147.1|9232620_9233514_-|NmrA/HSCARG-family-protein
MATKSEVVLVMGATGQQGGATARALLKDGWRVRALVRDPASARARELEAAGVELVRGDMGDRASLDRAVAGAYGVFSIQPSSAQASYGVTDDDEVRFGTSIADAAKAAGVEHFVYTSVLGLRPGTGVDHFETKWRIEEHVRASGLRATIVRPGTFMELLLVPDFGLTRGALQFFIQPEQPMQFIAGEDIGVLTARVFADPRTYVGTTLELAGDSLTGNALAEKIGRATGTSISYSRFPPEVLAASPMLRKLVKLFEDGFVFESADIPALRRLAPGLLTFDAWLERGGAAAIRERFAA
>NC_017030.1|WP_167594438.1|9232340_9232685_+|winged-helix-turn-helix-transcriptional-regulator
MRLLGGAWTANIVWRLSGDPRRFSELRSDIPRISAKVLSAKLRALEENGVLTRHAVASSPPSVEYALTPLGRELLPVIDTIVQVGMKLQRMQAAMPRSAPGSPRRPRAPATHRT
>NC_017030.1|WP_014400145.1|9231776_9232178_-|Dabb-family-protein
MFINLLRFRFRDGVPEEERARALEAISRTAKSEAVSFSVVGRDLGNPADGFTHAYCVGLADLSALRRYFDDPLHRAGDLLFLPLVGRLWRMALTDDADPALGEKIHAMHAEKMAGDPEWAALLSAIPDLQLQG
>NC_017030.1|WP_193352518.1|9230742_9231165_+|DUF3574-domain-containing-protein
MTAVASRLLLGLALVFGSGVTACGGDDGLDCKVGEPQYQTDLYFGRNRVNNEPVSEAEFQAFVDTVVTPRFQDGLTVYDANGQYQLESGELVHEQSKIIVLLHDGSAARSADIETIREEYKSQFDQESVLRIDSQPCVAF
>NC_017030.1|WP_014400142.1|9230221_9230635_-|hypothetical-protein
MTGAISLEALAEYIQDAFRDVHVDTSTPDLFFFAGDERKFPFATIVTRDTEFDHHSELDRDGVFRLNLGVSKESFQKLFPELDPNVDYTDLDVLLPHPAYARMFWLSVLNPSHETLRLLRPYLKEAHDLQVKRAARG
>NC_017030.1|WP_014400141.1|9229020_9230220_+|carotenoid-1,2-hydratase
MGRGLVIGVVLVLAALGVAVGVVLRDTEDTGPANTGGMTVASAMGGDGGTEGYARAMEPRPFHFPEDHGPHPDFRTEWWYWTGNLETQDGRAFGYQFTLFRSALSPEQPQRESGWGTRQVFMGHFTLTDVSAGKFHVTERFSRAAQGLAGADGAPFHVWLQDWDVRSEGTGGTWPMHLRAQGDGVTLELTLDEGKSPVLQGDKGLSQKGAERGNASYYYSMPRMPSRGTVSVDGQTVQVKGESWMDREWSTSALSGDQVGWDWFALQLSDGSELMLYQLRKKDGSKDTFSAGAYVPKTGEAVHLTADDMRLEPRGTWKSPRGGEYPAGWRVQVPKVSLELTVTPKLPDQELPVLVRYWEGAVTVDGKREGQPVQGRGYLEMTGYADVPRDEQTVRSRTP
>NC_017030.1|WP_014400140.1|9226476_9229017_+|ABC-transporter-permease
MRALLARSSLRHLGGHPWLTALSLLGIAMGVAVVVSIDLASGSALRAFEQSTDVVAGRATHQLTGGTSGLPEGVYTALKLRPDSPDAAPVVQGFVQVEGGNHRTLTLLGLDPFAEAPFRDFSTGGAVGDVSALLTRPGTVVMGAKTARSLGVKAGDTLPVTVTGLRRELRVSALLTPSQETTERALESLLIADISTAQEVLGLEGRLTRVDLRLKGGEAQAAALKATLPPGAELVQTSGRAGTVEQMTRAFRTNLTALSLLALVVGMFLIYNTMTFSVVQRRGMLGRLRAVGVTRGELFAVVLGEALLLGIVGTAAGLLLGILMASGLVGLITRTINDLYFVVNVRRLSLEPFTLIKGLSLGLGATVLAALVPAWEAARAAPVTALRRSTVEDVSRNRAPKLAVLGLIILAISAAVLAWPTQALMPAYTGLFGVLLGSSLLVPWVTEKLTKAAARPLGAMFGPLGRMAARGVTASLSRTAVALAALMVAVATTVGVGLMVSSFRGTVAAWLESALQADVFVSPPSLVARRGDSSLVPGLAEKLRSTPGVEASGSIRVIHVRINDVDTDLLAVDFAKGHERTYRFKEGRAEDVWRQLDASTDALIVSEPFAFHRDVHAGDTLRVATDKGPHDFRVAGVYFDYGSDVGTVLMPRATYEHWYEDRGVSGLSLFAAPGQDVDELVARVRDRAGGEQALNVRANRALRQASMEVFDRTFTITQVLRLLAIGVAFVGVLSALMSLQLERAREFAVLRATGLTPGQLWGMVSLQTGLLGLLAGLFSVPLGLALAYVLVHVINQRSFGWTLQLVVAPGVVGQALVLALVAAALAGLYPAWRMARANPAMALREE
>NC_017030.1|WP_014400139.1|9225751_9226480_+|ABC-transporter-ATP-binding-protein
MPSSPSDSRPLVELRAVTKSYAEGDSVREVLSGTSLALHRGEFVVLLGRSGSGKSTLLNLISGIDQATHGEILVEGRDLGRMPERDRTLLRRERIGFIFQAFNLLPTLTVEENVRLPLELLGRSSAEASARARELLERVGLGARANSFPDRLSGGEQQRVAVARALAHAPPLLLADEPTGNLDEETGGQVLDLLEGLTRQGHACALIVTHEPAMAERADRVLTMENGRLVERPGGARGRGTP
>NC_017030.1|WP_014400138.1|9223407_9225528_-|response-regulator
MNEAQAGWGAASGSVPPPLHELLQQLPAFFGLYRGPVHHIEFSTSTRLPLLDTHGQVGIPLREACPQLGGPGWHEAWDRVFATGEALHLREASARARTADEDLFFNLSLLPRRDAQGKVEGVLAFAVDVTELVRTRRAAWTTAAWRTERLQAMTAALSEALTPAQVVEVAAREGALAMGAVTGLVVVPAGAALDVFERAAAHGFAPGELEGWQRFEVSATCPLTDVTRTREPCALGSWTECMARYPRLAQLSRERTLAAWASVPLVSGGRVCGALGLGFGDARDFDAPERAFLLTVGRLCAQALDRARLYDEERAARSVAEAASRAKDAFLATVSHELRTPLTSILGWSQMLRQGLLGEDKRQRAVEAIERNARAQRQLIEDLLDISRIANGRLRLEPVPLELGHVVEAALDAVRPTALARELTLDVSVDADGVPLFGDPDRLQQVVWNLLSNAIKFTPPGGHVTVSARTRDEGAELVVRDDGEGIPADFLPFLFQRFQQADTGVSRQHGGLGLGLSIVRHLVELHGGTVTAVSDGLGKGATFTVVLPRTRVGTAPGSSRVPRPVEGLTLPRFPELEGQRVLVVDGQPDAREWMSVLLTRVGAHVLTATNVTDAMDEVRRSPPTVLVTDVTLAGEDGYSLLYRLRALPWESGGGVPALAVTAAARREDRDRALRAGFSAFVTKPLDAVELLTAVARLAPPPNPPGS
>NC_017030.1|WP_014400149.1|9234706_9235690_+|SDR-family-NAD(P)-dependent-oxidoreductase
MNVLVTGATGLIGNAIAQRLVKQGASVRALVRDLARASKLLPPSVRLIQGDVTSPGTLPAALHDVELVFHAAGMPEQWHRDDSIFDRVNRQGSVNVLSAAHAAKVRRVVYTSTMDVFAAPRGGELTEANIDPHPKPTVYERSKQEAERAVEAIRQQGLDVVFVNPAAVYGPSPVHVGLNSFFIQLLNKKAPLLPPGGMSVVHVDGCTDVHLAAAERGVNGERYLVSDQYVSTADLALAIHQAAGAGKPPAVAPVFLMEALARVSAPLARVFPFTPLVAPGQLSFMRWEARVNAAKAQRELAFRPTPLADGVAHTVAFLREQGHIPRA
>NC_017030.1|WP_014400150.1|9236078_9236315_+|hypothetical-protein
MALLSNLLGALGASQRTVFKGSGWNRGRSAYGRRPIGYGYRGRRSSGAGGSLGRMILAGLGAYGLRRYFNNRSRVTSY
>NC_017030.1|WP_014400151.1|9236529_9238014_+|glycerol-kinase-GlpK
MAKAKYVLALDQGTTGTHVSILDTRLQVVGRSYKELPQHFPKPSWVEHDLIDIWNTSEWCIARALKDAGLTGRDIAVVGITNQRETTGLWDRETSEPLARAIVWQDRRTADICQRLKAQGVEPRVREVTGLVLDPYFSGTKLTWLFQHLKGAKKRAERGDVCFGTMDSWLVHKLTGGVAHVTDVSNASRTLLMDLRTLNWDDELCSLLGVPRACLPEIRGNAEVYGTTRGMRSLPDGILVAGMAGDQQAALFGQACFEPGESKCTYGTGAFLLMNTGTQPVRSTAGLLTTVAWKLGNTTNYALEGSSFIAGAAVQWLRDGLKVIKKAPDVEALAASVKDSGDVVFVPALAGLGAPHWRPEARGLFAGIDRSTTVAHLARATLEGVALQIHDLAEAMRKDSGRNIPVFKADGGAAANNLLMQYQADLLGVPVVRPRNLETTSLGAAFLGGLGAGVWTSPDAIRRAWKADKTFKPKMKPEVRARHLEKWKQAVSRA
>NC_017030.1|WP_014400152.1|9238089_9238401_+|4a-hydroxytetrahydrobiopterin-dehydratase
MAYDRTLLSPDALQTFLTQHPAWKHEGGMIRRTYEAPSFLEGIAFVERVAKAAEAADHHPDIDIRWRKVTLALVTHDAGGLTPRDTALAAEADRLFSEGAAVR
>NC_017030.1|WP_167594439.1|9238421_9239654_+|hypothetical-protein
MAALACAVCFTALPALAQDDAPTEPRPERLYFNSGALLGSARVVGLGGAYVGIAEGAAGVSSNLAALAQRSPSLERDWDLGVTLSWLDLPFTGTKRRDVDNDGLADESVDSRQLLGALMLQYKRFGIGFLWRNSRTGYCLTPGCRGEGEKLRVSLTQSTLAGSIAFGQDDFILSLGIFSAQASFSEMGDQSWRYGDTGVAVDMLFRPHGRPYRIGVAVRPEVVAGWRRDDSQSPFIAGRRIYAAVVSPAVLSLGASWRLGEGAHRYNRLSPAARRQLQVDGDALPVPEEEPRDALAGRWLITAQVDLISSVSNAVASRSLAITTEPQPVGDTPTFQPRLGAEWDTFPGLLRLRAGTWLEPSPFRDRNPRPHLTGGFELFVLRYWEDWSLTASFDLASRYSNWGVSIGFWR
>NC_017030.1|WP_148282432.1|9239974_9241417_+|hypothetical-protein
MGCPPDEQPSIPGELPPPGSGTQTPPGNENPQTQPPPVKEPEVVPPASGATLWFAKEGAAQDDLALDLAVDATTGDFFTAAVHGYDDLDARTPTDDAVDLVLTRRSGAGQTLWTHAYDVRVESTPVELRADVRARVAADGAGGMLLAGNIQGTVDLGTGKLSNGAIVARLSADGATLWAHRVPGELTVKDVAADAEGRLYVAYTAPGTVDLGNEVKGASAGVAVFTADGTAERAFAVGSAESEGAGAEPLSLAPGADGSVAVAGRYTGTVRFGTNVTQGSGSGSPFVALYRQNGALGWAKVRPGVKGSVRDVSRDTAGAVVAGGDFQGSFSWAGASLKGASSPSPFVVVTGADGTERWARDLGVDASVQGVAIHSTGEVLVVGYTYSWLENGASGTDGLGSAQLFTQRFDPTGQPLASRLFLGTAPEARGELYGVEAVPAVTLMPDGDAVLYGYTDRVTDFGVDKFKPTRGDVFLLRVKY
>NC_017030.1|WP_014400155.1|9241421_9242897_-|ammonia-forming-cytochrome-c-nitrite-reductase-subunit-c552
MTEPEKAPEKRRLFSGIKLVVAVAVVAALASAGVTALLVNIMERKQEAKNPFYRVVELDDTITDPAVWGKNFPLQYDGYKRTVDQKRTRYGGSEAVARTPTQADPRSVVAQSRLEEDPRLVTMWSGYAFATDFREERGHAHMLEDQVFTQRQQVTQQPGTCIHCHGSVYVPYKKLGDGDLIKGFEKMNQMPFAEARKLVEHPVSCIDCHDPTTMQLRVTRPGFIEGIAALKASQGVPGFKVNQDATRQEMRTYVCGQCHVEYYFKGKEKRLTYPWAKGINIEQIMAYYDEDGHADWTHALTGAKVLKAQHPEFEMYNQGIHAKSGVACADCHMPYQREGAMKISDHHVRSPLLNINRACQTCHKWSEAELLNRAETIQTRTFQTRNIAMDALVDLIHDLESAQKAGAPEESLAKARDLQKRAQFYLDFVEAENSMGFHADQEAVRILSNSINFSRLGQNALRPGGGASTAPDQRPAGAPTPGSAGAPQGSK
>NC_017030.1|WP_014400156.1|9242893_9243412_-|cytochrome-c-nitrite-reductase-small-subunit
MLFASRTVLAVTLGIAIGVAVGLGGFTFAYAKGSSYLRDDPAACANCHIMNEQYDGWRKSSHHAVATCNDCHTPAGFLPKYYTKASNGFWHSFYFTTGTFPDPIRLRPGNRVVTENACRKCHASIVEAIETPPTGHGQVAPGEQLQCLTCHNSVGHPEGSGNPELIRKEIAR
>NC_017030.1|WP_014400157.1|9243521_9243842_+|hypothetical-protein
MSKRAAALLCLGLSSACAHYRVQAPGAAGASATEPQGEVLWSLGWGLVQERPRVDNCQGQALAEVTQSTNVGFALISVLTLGLAMPQRVEWRCAKAQPTPGDLGVR
>NC_017030.1|WP_014400158.1|9243844_9245356_+|FAD-binding-protein
MPPVIHESSQKRWQNWHQSYTQKLELLVDVWNADAPQSTVPGYIDTTVGLQGLIQRALTERLEIRGLGGGWSFTRAPATSGILVNTRPLNYLFPAPRTHPAHPGRREDLLFAQCGVSVAELSHFLKSIGKSLTTSGASNGQTIAGAIGTGTHGSSLETGAMQDFVVGLHVVVSPDRHVWLERASAPVIHDEIPQKLGAELIRDDALFNAALVGLGGFGLVHGVLMEVVDLYYLQAYRRRMPLDDGLWRALDQLDFSGITLPGPPGLKPYHFTAVINPNDLERGVFVTVMYKHARCPEGSSPPSPGSKLTQGDSALEIIGVLTDMVSELTIPLLARLMDRFYPEYENVCGTHGELFTDTTTRGKAWGSAVGVPLGRVRETVELALAINRTHAFPGLFGVRYALPSRAPLAFTQHAPMTCVLDIDGAASTRTKSYNRRVWQQLAESSIPHTYHWGKFHELDGPAVRSLYGEARVDAWLAARQSLLTTPELRTAFANDYLRELGLA

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Crispr_ID: NC_017030_38

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_38

9545363-9545437

Orphan

Consensus_repeat	Method
TCCGGCATCCACGGTGGTGCCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_38

>merge|NC_017030|38|9545363-9545437|CRISPRCasFinder
TCCGGCATCCACGGTGGTGCCCGCATCGTCCGTGGGCTGTTCCTCGTTGGATCCGGCATCCTCGGTGGTGCCCGC

>NC_017030|38|28|9545363-9545437|CRISPRCasFinder
TCCGGCATCCACGGTGGTGCCCGC	ATCGTCCGTGGGCTGTTCCTCGTTGGA
TCCGGCATCCTCGGTGGTGCCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014400420.1\|9550918_9551923_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400406.1\|9538506_9538896_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400416.1\|9546614_9549509_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235588
NC_017030.1\|WP_014400412.1\|9543165_9543792_-\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|173234
NC_017030.1\|WP_014400423.1\|9554573_9556010_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_017030.1\|WP_083892271.1\|9543933_9544287_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400409.1\|9539983_9541090_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_017030.1\|WP_014400408.1\|9539448_9539970_-\|HAD-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|224692
NC_017030.1\|WP_014400421.1\|9551922_9553593_-\|pilus-biogenesis-operon-protein	unknown	unknown	gnl\|CDD\|379164
NC_017030.1\|WP_014400407.1\|9539080_9539431_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_043324466.1\|9537214_9537454_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400418.1\|9549889_9550579_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400422.1\|9553598_9554405_-\|pilus-assembly-protein	unknown	unknown	gnl\|CDD\|377921
NC_017030.1\|WP_014400419.1\|9550592_9550916_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400410.1\|9541129_9542431_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|376615
NC_017030.1\|WP_014400411.1\|9542518_9543133_-\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|173234
NC_017030.1\|WP_014400405.1\|9537648_9538482_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235545
NC_017030.1\|WP_014400415.1\|9545812_9546571_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376668
NC_017030.1\|WP_014400424.1\|9556087_9557107_+\|RimK-family-alpha-L-glutamate-ligase	unknown	unknown	gnl\|CDD\|182468
NC_017030.1\|WP_014400417.1\|9549562_9549859_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014400416.1\|9546614_9549509_-\|isoleucine--tRNA-ligase	gnl\|CDD\|235588	PRK05743, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NC_017030.1\|WP_014400412.1\|9543165_9543792_-\|signal-peptidase-II	gnl\|CDD\|173234	PRK14773, PRK14773, lipoprotein signal peptidase; Provisional.	3.02644e-88
NC_017030.1\|WP_014400409.1\|9539983_9541090_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.60727e-07
NC_017030.1\|WP_014400408.1\|9539448_9539970_-\|HAD-hydrolase-family-protein	gnl\|CDD\|224692	COG1778, COG1778, Low specificity phosphatase (HAD superfamily) [General function prediction only].	2.92049e-56
NC_017030.1\|WP_014400421.1\|9551922_9553593_-\|pilus-biogenesis-operon-protein	gnl\|CDD\|379164	pfam13400, Tad, Putative Flp pilus-assembly TadE/G-like. This is an N-terminal domain on a family of putative Flp pilus-assembly proteins. The exact function is not known. The Flp-pilus biogenesis genes include the Tad genes, and some members of this family are putatively assigned as being TadG.	0.000321871
NC_017030.1\|WP_014400423.1\|9554573_9556010_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	4.30989e-128
NC_017030.1\|WP_014400422.1\|9553598_9554405_-\|pilus-assembly-protein	gnl\|CDD\|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	7.29134e-06
NC_017030.1\|WP_014400410.1\|9541129_9542431_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|376615	pfam01790, LGT, Prolipoprotein diacylglyceryl transferase.	3.92311e-45
NC_017030.1\|WP_014400411.1\|9542518_9543133_-\|signal-peptidase-II	gnl\|CDD\|173234	PRK14773, PRK14773, lipoprotein signal peptidase; Provisional.	4.57602e-81
NC_017030.1\|WP_014400405.1\|9537648_9538482_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235545	PRK05650, PRK05650, SDR family oxidoreductase.	5.85492e-91
NC_017030.1\|WP_014400415.1\|9545812_9546571_+\|hypothetical-protein	gnl\|CDD\|376668	pfam01927, Mut7-C, Mut7-C RNAse domain. RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C-terminus.	2.60344e-69
NC_017030.1\|WP_014400424.1\|9556087_9557107_+\|RimK-family-alpha-L-glutamate-ligase	gnl\|CDD\|182468	PRK10446, PRK10446, 30S ribosomal protein S6--L-glutamate ligase.	4.7634e-93

>NC_017030.1|WP_083892271.1|9543933_9544287_+|hypothetical-protein
MKPSAPDIAPPGTTTPPAAKPSLMARFKTLLVDYGPLAIAVNYLIFGLVIVGFWAAIRAGFQPQGTGAQAGAWGAAYLASQAVKPLRLAAVFVLTPLIARIPPVGRFIAKNKHKWSF
>NC_017030.1|WP_014400412.1|9543165_9543792_-|signal-peptidase-II
MKASFRLLLVVVLAVLAADQVTKYLAVSRLTEALDGRSGLSRVSGFLSEQNLDNDPPVEGVFRKNTRPYRFIEDYWHFRYVENPGAAWGMFSNLPETARKAFFHVVSLVALGFILTLYRKTEPSQKLVRVALALITGGALGNFMDRLIRGYVIDFIDWHWRNQPGMRWPTFNVADAAICVGVALMLLDSLRPEASAAQPLPQGTSPQP
>NC_017030.1|WP_014400411.1|9542518_9543133_-|signal-peptidase-II
MPRKYAILLALTLGVIVLDQWTKYLVVRDLTTRFDGATTLSQRLGAFYSPAEEPGRRGLHFQPKTHVEVAENFFRLRYAENPGAAWGMFRDLPPHVRGPLFHLVSLGAVLLIVFYFRKLSGTDPAEVWALWGLPLVLGGALGNYIDRVARAFVIDFLEAHWYDKAAWPSFNVADMAICIGVGMLVVDAFVRKEKPEASAPAKAS
>NC_017030.1|WP_014400410.1|9541129_9542431_-|prolipoprotein-diacylglyceryl-transferase
MLPVLLRLSFTTLWMQLLLYAVAVGVVASVAVNGWKGTLGPVDAETGKEGPAPLQDKLWRAVGFAAAGGFLAYFGLKYALPADAFPGGKGEGIPLHTYGLLLALGFTTAVAVAARLAQDEWRRVTLVPGRGWVDTEGPQKREQVMDLAFWVLVGGLVGSRVLFVLVNWQDYARDWTQVFSLGGGLVFYGGLIGAGLAAYLFARRHDLDFLRLADVCIPTVSLGQCLGRLGCFSAGCCWGDMAGSHSHTGVTFPGSGLAQDLFGQLGRASSLAYGSQAGDGRFVVEATGQVLHEWAPGAVRISDWVAQHGTTLPVYPTQLFESVGQLVLFVALLYARRFRRFHGHIFALWLMAYACLRTTVELFRGDVERGTLHGLLESLGAQGLAGAVPLEAWYNVSTSQFISLCMFTFGALLMARHRPAGEAAGLGPTPSAA
>NC_017030.1|WP_014400409.1|9539983_9541090_-|hypothetical-protein
MPPPDNARPAAKGGARPAQQDASSSSEAALQQCEELEAAIAELRHSYEQYFMGMERQAPIRAHEDLKKRMLKLKGAFIRSTSVKFRVQSLHNKFLTYERLWTRTLQEIEAGTYRRDLAKARRRAGAKQAGATGDRQKGVVEIPEEVDDMDFEEIEELTGRRPINEPKLASEYQAEQQAGGGTPFRGSPAVAPVAAQPAGAPRGTPAGLVPPKQSVPAVSPMSGLPSIAPMGTPAAGTSKLPSVTPSVAPGGTPAAGRAAVPPGMATKAPAAAPQQPARPAAPAAAAAPRPAAAGPGGGMSDDKLRAVYDAYVTAKRRCQEDTSKLSYESVAATLRKQVPELLKQHNAKAVEFKVVIKDGKASLKAVPK
>NC_017030.1|WP_014400408.1|9539448_9539970_-|HAD-hydrolase-family-protein
MNQDLESLKARVARLSVMIFDIDGTLTDGRIFWVPNSGWTQMYSVRDGMGIKRLQEVGIEVAAISGGDSLSAQMRMQSLGLRHVHFGSQDKVAHFEKLLGILNVSAENCGYMGDEVVDLPLLNAVGFSATVPEAPDEVRAQVHYVAQRAAGFGAAREVCEFILKHRTRSAPAT
>NC_017030.1|WP_014400407.1|9539080_9539431_-|hypothetical-protein
MKWGMLLGVGILGLTGCASVMGPKEPDSPPVGRATVKCVITKKGRAEQCRAITWDPTVSNARLAQGIRDIESTQYGPEEGERYGWYAEDHPYTFELRFWDPPVTDGGLTASTSLQP
>NC_017030.1|WP_014400406.1|9538506_9538896_-|hypothetical-protein
MGMRRMWLGLAVAVGLAVSTGCGQSPEDSEARLAVLEAEGKQMDQALDAVEDRLLGSQGRLAMWNELGRRHQEVSAIQCKVADAHMAAILKHEDKQNQKARMVKQRNSMASVDTAVLTSGKAPAQQRSN
>NC_017030.1|WP_014400405.1|9537648_9538482_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSLPSRPRAVVTGAGSGLGRALCEALAARQARVMVSDMNAASAEETARRVTELGGEARVHPCDVTDPDAVEALARATDEAFGGVDLVVNNAGVATGGAVGTLPLSEWKRVLDVNLWGVIHGCHAFVPRLKKQGSGHVLNIASAAGLVYAPNLAAYNTSKAAVVALSETLYAELQPLGLGVTVACPTFFRTNLASAAAPYADPETRRMSVKLVDQSKIGPEWVAERLLKAVDQGAPHVLPMADARWFWRLRRLAPRLFLWGVIAVEKRMRERTARIPG
>NC_017030.1|WP_043324466.1|9537214_9537454_-|hypothetical-protein
MAVVAVAAAALLGCNDLENCGSTPVDITRTDGGLYRCVTSEDCPRTSRVSVCVTDVSSERECVRCDETRCVRLIPESCQ
>NC_017030.1|WP_014400415.1|9545812_9546571_+|hypothetical-protein
MSSRQLTVRIHGALNDFVAPERRGQAFTHVLQGSPSVKDLIESLGPPHPEVDVVLVDGEPVGFAHRAEEGTSIDVYPASDPSAPQVARVGPPIPEMPRFILDVGLGRLSGFLRMLGFDTLWRNDSADDQLARLSHDEERVLLTRDLGVLKRSEVVLGYFPRETDPAHQLVEVVRRYGLTSRMRPFSRCIACNAPLSTATPEEVQGRVPEGVTQRHSRFQQCPGCQRVFWPGTHHERMQNLVETLRKLEAANP
>NC_017030.1|WP_014400416.1|9546614_9549509_-|isoleucine--tRNA-ligase
MSDAPSRKDLDATVHLPRTEFPMKGNLGQLEPRLLAWWREQDVWTQLLAKNAGREPFVLADGPPYANGHLHAGHALNKVLKDIVVKFRNLSGRPCDFIPGWDTHGLPIEQAVEKRLKEQKLDKRTLSRDALLERCREYALEFVDIQRAEFQRLGVFGTWDAPYRTLDFSYEAQEVRELAAFARRGMLYRRKKPVAWCLQDQTALAEAEVEYAEHTSPSAYVAFDAGPALVEKLPQLKGHRVSFVIWTTTPWTLPANLAIAVNAGFEYVFYRLEDRVLCVAKDLLAKVLAEVKSDELAVKHVQLPTGEVSSPALVDPSRILAYATGEDLEHMTYQHPFLERQGHVVLGEHVTLDAGTGLVHTAPGHGQEDYEVGLKYGLDIYNPVRADGRYDDTVGEVLAGRRVFEANPVVLDLLVQRGALLNDKSDTVTHSYPHCWRCHQPVIQAATYQWFIPMDAPFHGTQTFRQVVLEQVEQVQWVPSWGQSRIRGMLEGRPDWCISRQRSWGVPIPIAYCDGCDDAVVSPEVMERVAAAVEQEGAGVWYRTPVKEFLGADFTCPRCGKGEFHRETDILDVWFDSACMASAVLTKRQRVPADLFLEGSDQHRGWFHSSLLVSVGTRDVAPYKACLTHGFVVDGQGEKMSKSRGNTVAPDKVIQQYGAEVLRLWVAASDYRNDVRLSDAILKGLSEGYRKIRNTLRYALGNLHDFDPAKDAVAGDKLLPLDQWARGRLAQVAARVRQAYEDYEFHLVYATVVDFCANDLSAVYFDILKDRLYTAKQDGSARRGAQTVLHEVLTVLLPLLAPVMSFTAEEAWQHLPGERAKSVFLAGFTEVKATMPPELEARYAKLFAVRSAVQGVLEVARRDKRIGASLEARVALSATGAVRELLEAHRAELPGLFIVSQVELANAPSDSAKALDVSQTFGENASLSAEVLPALGTKCPRCWVYSEAVGQGDDVCLKCREALS
>NC_017030.1|WP_014400417.1|9549562_9549859_-|hypothetical-protein
MTTRIAVRGWLGLMALGAVLVAPQALAQTCDEKCSINAGPTMQACVKKCSAKDRNCTDKCTKAFQAAKAKCAKKCPKGKGKNTPQPHTHEHGDDHHDE
>NC_017030.1|WP_014400418.1|9549889_9550579_-|hypothetical-protein
MKRGFGRWALLLSLMGAAPAWAQRANFTWDIPKTVSVVDVPGQVDANGVPVKLLAVRSKEKPQVILQSVVDRFQSWGFSVQEAYKQPQLLREPMVTGLDTRNFISYTAILQVNPDGTTTVFLGQANLGAAKAPQPAGLPVFPGGAGVLTAQTEGSHTVSYSVPGKTTAEVEAFYREVLTKAGFKEIQPRVFKSSTEEVALNVAVTKEGPVAVRLVRRAAAPDDDMRPGE
>NC_017030.1|WP_014400419.1|9550592_9550916_-|hypothetical-protein
MKMRSLLSGGVLAFMLCLTASPARADSNSCNTDCATKNGDTLNACITACPAPSSPGSAKDSSRTCSARCAQKFQAQFNQCKARCPKPEGDTGPKSGKSVKAARSHRG
>NC_017030.1|WP_014400420.1|9550918_9551923_-|hypothetical-protein
MHRHLRRHPRQARGQSIVEAALGVTLFITILVFGIHFAEVGFLSLKVQEAAVSALWNGTHGRMHSLLISDFDPAEDSMRQGGEDAQARYADFNGLSSVNRGDTITQVFTRGSDLRVSCGRNGGLGWNGPVLTRLLFRDQGGSACTSQATLSAWNIPSRFLDQTPETGLYNEQHLDAANAAIQVCGIGRAVGGSCQGRFSMLVDDWGLASEEETTTCLLFQDMAVPCTNAAFYVVTKGVYEPTTLPIPTYASFLAMDALFMNPLPPLVLMQRENTFWMSAAGEETNFMQYFMKPAALGNLWNTTPGAMIGITTPHYGLGYLDRTGNGGCFLGKDC
>NC_017030.1|WP_014400421.1|9551922_9553593_-|pilus-biogenesis-operon-protein
MRRSFSQRGQTLVLFVLSMLLLLLMVALTLSFTMKVRERIEVQTVADAAAYSNAVATARTFNTIAVSNRAEIAHMVANAGAASLLSWASLYRGELNAAKIGYGAWLPVYQAFATAGCPCAWSNGFCARMCQCGVRGVTDLGRLITTLQREDLRVEAVFQALDPMVGLQMRLHQVAAGALYASSLEDYMSLEDKVGDQGFANDILGDLVAGKNPRDAGWLAPSAGNVSRNELADNTACVGGGAVCDPLPLTVAHSVDAAMGSRGFTFVTSRTIEQYIAHEANLAFVILPPDIVTLPFAAGTAHFGKPILQYGLFPPYAPAVSAEDEGVVAFIYNHIAHGGGPPCPVMVGGTVPTTALFAASGGVMPTPMHMWLGGTDPAPFARHMLAPCLGGVSSCPGIWPPFMDYNLTELWPGGADNNYGQPKNFAVIQRDRSNMPVAQQDPWNLAFRFRFKAANPNPNAGRFDNTSATMADGVTPLGIQTALSTGIAYYHRGRSASFSHWSEPPNLLNPYWRATLVPVDTDETGLQDAIDTLRPTSPSSAQTIEELRRVGFRGFQ
>NC_017030.1|WP_014400422.1|9553598_9554405_-|pilus-assembly-protein
MSARSPREAGESGQALVEAALSLPLVTFLILGALQLFLMMQARVMTHYAAFRATRAGSVAHGDCERMTHAAILALIPTFHSFMGQGTGSLNGPLGRGAGSDAPRLLAEAFAARMNNRYAGSGGPGPGMDGVHNRSIVWIQRDLAGGGVDSPEDSDFDRPGHLRRLEVQLVFWYPLRIPFANWVMSRMFLAHFSLRSYTDANPLIVAERSANWNGSDVTTSHVLDGELGAELAERVLNRQYVFPIITTFTMRMMTPVKSRFFATMACPR
>NC_017030.1|WP_014400423.1|9554573_9556010_-|sigma-54-dependent-Fis-family-transcriptional-regulator
MTAPNPHPDDIHTNPGDVGLELSSQSPLLGETLVVDSRASVKLHKCRLLVTSGPDTGRSMVSDKERLRCGAHPGNDLVLVEDRTASRHHFEVQYTERGHLLVDLNSTNGTFLDGRRIERAYLSPGSQIRAGSSVITFAPLDEEVAVEPDREGELCGMVGQSVKMRQVFGLIKRIAPMDVSVIIQGETGTGKELVSSAIHELSGRKKGPMVVLDCGAIPPNLIESELFGHEKGAFTGATSSRPGAFERAQGGTIFLDELGELRLDLQPKLLRVLENREVRRVGGNDVIEVDCRVIAATHRDLVKEIAAGNFREDLYFRLSVIHIQLPPLRQRRDDIPLILKRALAEPEVVETHGRKRFSAEALGLLMAYAWPGNVRELMNVLSHVLTFSDEGEEILPSHLPPRVRGQAREGPLPFNEHLAFKDAKEQLLENFEREYVTSVLTRCEGNLSRAARESGLHRKSIERLVKKYQLDAKGLKPR
>NC_017030.1|WP_014400424.1|9556087_9557107_+|RimK-family-alpha-L-glutamate-ligase
MPPRKAQPKKAPVPPGAQAPERGDAPRPKRPRAKKTVAILSRKRSLYSTRRLVEAIKAQGHRALVFDTLRCCLLLARGQPRMTYRGAEVKGVDVVIPRIGASITAYGLAVVNHFEMMDVPVLNPPTAIARSRDKLRALQFLARAGLDMPRTVMAHDRGNVRKLVQEVGGLPVIIKLIKGTQGVGVMIAHTLPEVQTILDTFWDLGQEIVLQEFVAESEGRDVRALVVGDTVVGAMRRKAKKGEFRSNIHRGGEGRAITLPPDYMEAAVKAARIIGLEVAGVDMLEGREGPRLMEINSSPGFEGLEGATGKDIAGHIVEHALVYAGTRASALRTRAGRAS

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Crispr_ID: NC_017030_37

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_017030_37

9545222-9545300

Orphan

Consensus_repeat	Method
TCCGGCATCCACGGTGGTGCCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_017030_37

>merge|NC_017030|37|9545222-9545300|CRISPRCasFinder
GCCCGCGTCGGTCGTGGTGCCCGCATCCGTCGCGGAACCGGCATCCGTCGAAGTGCCCGCATCGGTGGTGGTGCCAGCG

>NC_017030|37|27|9545222-9545300|CRISPRCasFinder
GCCCGCGTCGGTCGTGGTGCCCGC	ATCCGTCGCGGAACCGGCATCCGTCGAAGT
GCCCGCATCGGTGGTGGTGCCAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_017030.1\|WP_014400420.1\|9550918_9551923_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400406.1\|9538506_9538896_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400416.1\|9546614_9549509_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235588
NC_017030.1\|WP_014400412.1\|9543165_9543792_-\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|173234
NC_017030.1\|WP_014400423.1\|9554573_9556010_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_017030.1\|WP_083892271.1\|9543933_9544287_+\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400409.1\|9539983_9541090_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NC_017030.1\|WP_014400408.1\|9539448_9539970_-\|HAD-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|224692
NC_017030.1\|WP_014400421.1\|9551922_9553593_-\|pilus-biogenesis-operon-protein	unknown	unknown	gnl\|CDD\|379164
NC_017030.1\|WP_014400407.1\|9539080_9539431_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_043324466.1\|9537214_9537454_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400418.1\|9549889_9550579_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400422.1\|9553598_9554405_-\|pilus-assembly-protein	unknown	unknown	gnl\|CDD\|377921
NC_017030.1\|WP_014400419.1\|9550592_9550916_-\|hypothetical-protein	unknown	unknown	unknown
NC_017030.1\|WP_014400410.1\|9541129_9542431_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|376615
NC_017030.1\|WP_014400411.1\|9542518_9543133_-\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|173234
NC_017030.1\|WP_014400405.1\|9537648_9538482_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235545
NC_017030.1\|WP_014400415.1\|9545812_9546571_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376668
NC_017030.1\|WP_014400424.1\|9556087_9557107_+\|RimK-family-alpha-L-glutamate-ligase	unknown	unknown	gnl\|CDD\|182468
NC_017030.1\|WP_014400417.1\|9549562_9549859_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_017030.1\|WP_014400416.1\|9546614_9549509_-\|isoleucine--tRNA-ligase	gnl\|CDD\|235588	PRK05743, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NC_017030.1\|WP_014400412.1\|9543165_9543792_-\|signal-peptidase-II	gnl\|CDD\|173234	PRK14773, PRK14773, lipoprotein signal peptidase; Provisional.	3.02644e-88
NC_017030.1\|WP_014400409.1\|9539983_9541090_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.60727e-07
NC_017030.1\|WP_014400408.1\|9539448_9539970_-\|HAD-hydrolase-family-protein	gnl\|CDD\|224692	COG1778, COG1778, Low specificity phosphatase (HAD superfamily) [General function prediction only].	2.92049e-56
NC_017030.1\|WP_014400421.1\|9551922_9553593_-\|pilus-biogenesis-operon-protein	gnl\|CDD\|379164	pfam13400, Tad, Putative Flp pilus-assembly TadE/G-like. This is an N-terminal domain on a family of putative Flp pilus-assembly proteins. The exact function is not known. The Flp-pilus biogenesis genes include the Tad genes, and some members of this family are putatively assigned as being TadG.	0.000321871
NC_017030.1\|WP_014400423.1\|9554573_9556010_-\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	4.30989e-128
NC_017030.1\|WP_014400422.1\|9553598_9554405_-\|pilus-assembly-protein	gnl\|CDD\|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	7.29134e-06
NC_017030.1\|WP_014400410.1\|9541129_9542431_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|376615	pfam01790, LGT, Prolipoprotein diacylglyceryl transferase.	3.92311e-45
NC_017030.1\|WP_014400411.1\|9542518_9543133_-\|signal-peptidase-II	gnl\|CDD\|173234	PRK14773, PRK14773, lipoprotein signal peptidase; Provisional.	4.57602e-81
NC_017030.1\|WP_014400405.1\|9537648_9538482_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|235545	PRK05650, PRK05650, SDR family oxidoreductase.	5.85492e-91
NC_017030.1\|WP_014400415.1\|9545812_9546571_+\|hypothetical-protein	gnl\|CDD\|376668	pfam01927, Mut7-C, Mut7-C RNAse domain. RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C-terminus.	2.60344e-69
NC_017030.1\|WP_014400424.1\|9556087_9557107_+\|RimK-family-alpha-L-glutamate-ligase	gnl\|CDD\|182468	PRK10446, PRK10446, 30S ribosomal protein S6--L-glutamate ligase.	4.7634e-93

>NC_017030.1|WP_083892271.1|9543933_9544287_+|hypothetical-protein
MKPSAPDIAPPGTTTPPAAKPSLMARFKTLLVDYGPLAIAVNYLIFGLVIVGFWAAIRAGFQPQGTGAQAGAWGAAYLASQAVKPLRLAAVFVLTPLIARIPPVGRFIAKNKHKWSF
>NC_017030.1|WP_014400412.1|9543165_9543792_-|signal-peptidase-II
MKASFRLLLVVVLAVLAADQVTKYLAVSRLTEALDGRSGLSRVSGFLSEQNLDNDPPVEGVFRKNTRPYRFIEDYWHFRYVENPGAAWGMFSNLPETARKAFFHVVSLVALGFILTLYRKTEPSQKLVRVALALITGGALGNFMDRLIRGYVIDFIDWHWRNQPGMRWPTFNVADAAICVGVALMLLDSLRPEASAAQPLPQGTSPQP
>NC_017030.1|WP_014400411.1|9542518_9543133_-|signal-peptidase-II
MPRKYAILLALTLGVIVLDQWTKYLVVRDLTTRFDGATTLSQRLGAFYSPAEEPGRRGLHFQPKTHVEVAENFFRLRYAENPGAAWGMFRDLPPHVRGPLFHLVSLGAVLLIVFYFRKLSGTDPAEVWALWGLPLVLGGALGNYIDRVARAFVIDFLEAHWYDKAAWPSFNVADMAICIGVGMLVVDAFVRKEKPEASAPAKAS
>NC_017030.1|WP_014400410.1|9541129_9542431_-|prolipoprotein-diacylglyceryl-transferase
MLPVLLRLSFTTLWMQLLLYAVAVGVVASVAVNGWKGTLGPVDAETGKEGPAPLQDKLWRAVGFAAAGGFLAYFGLKYALPADAFPGGKGEGIPLHTYGLLLALGFTTAVAVAARLAQDEWRRVTLVPGRGWVDTEGPQKREQVMDLAFWVLVGGLVGSRVLFVLVNWQDYARDWTQVFSLGGGLVFYGGLIGAGLAAYLFARRHDLDFLRLADVCIPTVSLGQCLGRLGCFSAGCCWGDMAGSHSHTGVTFPGSGLAQDLFGQLGRASSLAYGSQAGDGRFVVEATGQVLHEWAPGAVRISDWVAQHGTTLPVYPTQLFESVGQLVLFVALLYARRFRRFHGHIFALWLMAYACLRTTVELFRGDVERGTLHGLLESLGAQGLAGAVPLEAWYNVSTSQFISLCMFTFGALLMARHRPAGEAAGLGPTPSAA
>NC_017030.1|WP_014400409.1|9539983_9541090_-|hypothetical-protein
MPPPDNARPAAKGGARPAQQDASSSSEAALQQCEELEAAIAELRHSYEQYFMGMERQAPIRAHEDLKKRMLKLKGAFIRSTSVKFRVQSLHNKFLTYERLWTRTLQEIEAGTYRRDLAKARRRAGAKQAGATGDRQKGVVEIPEEVDDMDFEEIEELTGRRPINEPKLASEYQAEQQAGGGTPFRGSPAVAPVAAQPAGAPRGTPAGLVPPKQSVPAVSPMSGLPSIAPMGTPAAGTSKLPSVTPSVAPGGTPAAGRAAVPPGMATKAPAAAPQQPARPAAPAAAAAPRPAAAGPGGGMSDDKLRAVYDAYVTAKRRCQEDTSKLSYESVAATLRKQVPELLKQHNAKAVEFKVVIKDGKASLKAVPK
>NC_017030.1|WP_014400408.1|9539448_9539970_-|HAD-hydrolase-family-protein
MNQDLESLKARVARLSVMIFDIDGTLTDGRIFWVPNSGWTQMYSVRDGMGIKRLQEVGIEVAAISGGDSLSAQMRMQSLGLRHVHFGSQDKVAHFEKLLGILNVSAENCGYMGDEVVDLPLLNAVGFSATVPEAPDEVRAQVHYVAQRAAGFGAAREVCEFILKHRTRSAPAT
>NC_017030.1|WP_014400407.1|9539080_9539431_-|hypothetical-protein
MKWGMLLGVGILGLTGCASVMGPKEPDSPPVGRATVKCVITKKGRAEQCRAITWDPTVSNARLAQGIRDIESTQYGPEEGERYGWYAEDHPYTFELRFWDPPVTDGGLTASTSLQP
>NC_017030.1|WP_014400406.1|9538506_9538896_-|hypothetical-protein
MGMRRMWLGLAVAVGLAVSTGCGQSPEDSEARLAVLEAEGKQMDQALDAVEDRLLGSQGRLAMWNELGRRHQEVSAIQCKVADAHMAAILKHEDKQNQKARMVKQRNSMASVDTAVLTSGKAPAQQRSN
>NC_017030.1|WP_014400405.1|9537648_9538482_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSLPSRPRAVVTGAGSGLGRALCEALAARQARVMVSDMNAASAEETARRVTELGGEARVHPCDVTDPDAVEALARATDEAFGGVDLVVNNAGVATGGAVGTLPLSEWKRVLDVNLWGVIHGCHAFVPRLKKQGSGHVLNIASAAGLVYAPNLAAYNTSKAAVVALSETLYAELQPLGLGVTVACPTFFRTNLASAAAPYADPETRRMSVKLVDQSKIGPEWVAERLLKAVDQGAPHVLPMADARWFWRLRRLAPRLFLWGVIAVEKRMRERTARIPG
>NC_017030.1|WP_043324466.1|9537214_9537454_-|hypothetical-protein
MAVVAVAAAALLGCNDLENCGSTPVDITRTDGGLYRCVTSEDCPRTSRVSVCVTDVSSERECVRCDETRCVRLIPESCQ
>NC_017030.1|WP_014400415.1|9545812_9546571_+|hypothetical-protein
MSSRQLTVRIHGALNDFVAPERRGQAFTHVLQGSPSVKDLIESLGPPHPEVDVVLVDGEPVGFAHRAEEGTSIDVYPASDPSAPQVARVGPPIPEMPRFILDVGLGRLSGFLRMLGFDTLWRNDSADDQLARLSHDEERVLLTRDLGVLKRSEVVLGYFPRETDPAHQLVEVVRRYGLTSRMRPFSRCIACNAPLSTATPEEVQGRVPEGVTQRHSRFQQCPGCQRVFWPGTHHERMQNLVETLRKLEAANP
>NC_017030.1|WP_014400416.1|9546614_9549509_-|isoleucine--tRNA-ligase
MSDAPSRKDLDATVHLPRTEFPMKGNLGQLEPRLLAWWREQDVWTQLLAKNAGREPFVLADGPPYANGHLHAGHALNKVLKDIVVKFRNLSGRPCDFIPGWDTHGLPIEQAVEKRLKEQKLDKRTLSRDALLERCREYALEFVDIQRAEFQRLGVFGTWDAPYRTLDFSYEAQEVRELAAFARRGMLYRRKKPVAWCLQDQTALAEAEVEYAEHTSPSAYVAFDAGPALVEKLPQLKGHRVSFVIWTTTPWTLPANLAIAVNAGFEYVFYRLEDRVLCVAKDLLAKVLAEVKSDELAVKHVQLPTGEVSSPALVDPSRILAYATGEDLEHMTYQHPFLERQGHVVLGEHVTLDAGTGLVHTAPGHGQEDYEVGLKYGLDIYNPVRADGRYDDTVGEVLAGRRVFEANPVVLDLLVQRGALLNDKSDTVTHSYPHCWRCHQPVIQAATYQWFIPMDAPFHGTQTFRQVVLEQVEQVQWVPSWGQSRIRGMLEGRPDWCISRQRSWGVPIPIAYCDGCDDAVVSPEVMERVAAAVEQEGAGVWYRTPVKEFLGADFTCPRCGKGEFHRETDILDVWFDSACMASAVLTKRQRVPADLFLEGSDQHRGWFHSSLLVSVGTRDVAPYKACLTHGFVVDGQGEKMSKSRGNTVAPDKVIQQYGAEVLRLWVAASDYRNDVRLSDAILKGLSEGYRKIRNTLRYALGNLHDFDPAKDAVAGDKLLPLDQWARGRLAQVAARVRQAYEDYEFHLVYATVVDFCANDLSAVYFDILKDRLYTAKQDGSARRGAQTVLHEVLTVLLPLLAPVMSFTAEEAWQHLPGERAKSVFLAGFTEVKATMPPELEARYAKLFAVRSAVQGVLEVARRDKRIGASLEARVALSATGAVRELLEAHRAELPGLFIVSQVELANAPSDSAKALDVSQTFGENASLSAEVLPALGTKCPRCWVYSEAVGQGDDVCLKCREALS
>NC_017030.1|WP_014400417.1|9549562_9549859_-|hypothetical-protein
MTTRIAVRGWLGLMALGAVLVAPQALAQTCDEKCSINAGPTMQACVKKCSAKDRNCTDKCTKAFQAAKAKCAKKCPKGKGKNTPQPHTHEHGDDHHDE
>NC_017030.1|WP_014400418.1|9549889_9550579_-|hypothetical-protein
MKRGFGRWALLLSLMGAAPAWAQRANFTWDIPKTVSVVDVPGQVDANGVPVKLLAVRSKEKPQVILQSVVDRFQSWGFSVQEAYKQPQLLREPMVTGLDTRNFISYTAILQVNPDGTTTVFLGQANLGAAKAPQPAGLPVFPGGAGVLTAQTEGSHTVSYSVPGKTTAEVEAFYREVLTKAGFKEIQPRVFKSSTEEVALNVAVTKEGPVAVRLVRRAAAPDDDMRPGE
>NC_017030.1|WP_014400419.1|9550592_9550916_-|hypothetical-protein
MKMRSLLSGGVLAFMLCLTASPARADSNSCNTDCATKNGDTLNACITACPAPSSPGSAKDSSRTCSARCAQKFQAQFNQCKARCPKPEGDTGPKSGKSVKAARSHRG
>NC_017030.1|WP_014400420.1|9550918_9551923_-|hypothetical-protein
MHRHLRRHPRQARGQSIVEAALGVTLFITILVFGIHFAEVGFLSLKVQEAAVSALWNGTHGRMHSLLISDFDPAEDSMRQGGEDAQARYADFNGLSSVNRGDTITQVFTRGSDLRVSCGRNGGLGWNGPVLTRLLFRDQGGSACTSQATLSAWNIPSRFLDQTPETGLYNEQHLDAANAAIQVCGIGRAVGGSCQGRFSMLVDDWGLASEEETTTCLLFQDMAVPCTNAAFYVVTKGVYEPTTLPIPTYASFLAMDALFMNPLPPLVLMQRENTFWMSAAGEETNFMQYFMKPAALGNLWNTTPGAMIGITTPHYGLGYLDRTGNGGCFLGKDC
>NC_017030.1|WP_014400421.1|9551922_9553593_-|pilus-biogenesis-operon-protein
MRRSFSQRGQTLVLFVLSMLLLLLMVALTLSFTMKVRERIEVQTVADAAAYSNAVATARTFNTIAVSNRAEIAHMVANAGAASLLSWASLYRGELNAAKIGYGAWLPVYQAFATAGCPCAWSNGFCARMCQCGVRGVTDLGRLITTLQREDLRVEAVFQALDPMVGLQMRLHQVAAGALYASSLEDYMSLEDKVGDQGFANDILGDLVAGKNPRDAGWLAPSAGNVSRNELADNTACVGGGAVCDPLPLTVAHSVDAAMGSRGFTFVTSRTIEQYIAHEANLAFVILPPDIVTLPFAAGTAHFGKPILQYGLFPPYAPAVSAEDEGVVAFIYNHIAHGGGPPCPVMVGGTVPTTALFAASGGVMPTPMHMWLGGTDPAPFARHMLAPCLGGVSSCPGIWPPFMDYNLTELWPGGADNNYGQPKNFAVIQRDRSNMPVAQQDPWNLAFRFRFKAANPNPNAGRFDNTSATMADGVTPLGIQTALSTGIAYYHRGRSASFSHWSEPPNLLNPYWRATLVPVDTDETGLQDAIDTLRPTSPSSAQTIEELRRVGFRGFQ
>NC_017030.1|WP_014400422.1|9553598_9554405_-|pilus-assembly-protein
MSARSPREAGESGQALVEAALSLPLVTFLILGALQLFLMMQARVMTHYAAFRATRAGSVAHGDCERMTHAAILALIPTFHSFMGQGTGSLNGPLGRGAGSDAPRLLAEAFAARMNNRYAGSGGPGPGMDGVHNRSIVWIQRDLAGGGVDSPEDSDFDRPGHLRRLEVQLVFWYPLRIPFANWVMSRMFLAHFSLRSYTDANPLIVAERSANWNGSDVTTSHVLDGELGAELAERVLNRQYVFPIITTFTMRMMTPVKSRFFATMACPR
>NC_017030.1|WP_014400423.1|9554573_9556010_-|sigma-54-dependent-Fis-family-transcriptional-regulator
MTAPNPHPDDIHTNPGDVGLELSSQSPLLGETLVVDSRASVKLHKCRLLVTSGPDTGRSMVSDKERLRCGAHPGNDLVLVEDRTASRHHFEVQYTERGHLLVDLNSTNGTFLDGRRIERAYLSPGSQIRAGSSVITFAPLDEEVAVEPDREGELCGMVGQSVKMRQVFGLIKRIAPMDVSVIIQGETGTGKELVSSAIHELSGRKKGPMVVLDCGAIPPNLIESELFGHEKGAFTGATSSRPGAFERAQGGTIFLDELGELRLDLQPKLLRVLENREVRRVGGNDVIEVDCRVIAATHRDLVKEIAAGNFREDLYFRLSVIHIQLPPLRQRRDDIPLILKRALAEPEVVETHGRKRFSAEALGLLMAYAWPGNVRELMNVLSHVLTFSDEGEEILPSHLPPRVRGQAREGPLPFNEHLAFKDAKEQLLENFEREYVTSVLTRCEGNLSRAARESGLHRKSIERLVKKYQLDAKGLKPR
>NC_017030.1|WP_014400424.1|9556087_9557107_+|RimK-family-alpha-L-glutamate-ligase
MPPRKAQPKKAPVPPGAQAPERGDAPRPKRPRAKKTVAILSRKRSLYSTRRLVEAIKAQGHRALVFDTLRCCLLLARGQPRMTYRGAEVKGVDVVIPRIGASITAYGLAVVNHFEMMDVPVLNPPTAIARSRDKLRALQFLARAGLDMPRTVMAHDRGNVRKLVQEVGGLPVIIKLIKGTQGVGVMIAHTLPEVQTILDTFWDLGQEIVLQEFVAESEGRDVRALVVGDTVVGAMRRKAKKGEFRSNIHRGGEGRAITLPPDYMEAAVKAARIIGLEVAGVDMLEGREGPRLMEINSSPGFEGLEGATGKDIAGHIVEHALVYAGTRASALRTRAGRAS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_017030_34	34.4\|8064138\|39\|NC_017030\|PILER-CR	8064138-8064176	39	NC_017030.1	8064266-8064304	0	1.0
NC_017030_32	32.5\|7747121\|19\|NC_017030\|CRT	7747121-7747139	19	NC_017030.1	69216-69234	2	0.895
NC_017030_32	32.5\|7747121\|19\|NC_017030\|CRT	7747121-7747139	19	NC_017030.1	7226172-7226190	2	0.895
NC_017030_32	32.8\|7747256\|19\|NC_017030\|CRT	7747256-7747274	19	NC_017030.1	1813765-1813783	2	0.895

1. spacer 34.4|8064138|39|NC_017030|PILER-CR matches to position: 8064266-8064304, mismatch: 0, identity: 1.0

agatggcgaggctgcggacgcggtcgcgctgagcaccaa	CRISPR spacer
agatggcgaggctgcggacgcggtcgcgctgagcaccaa	Protospacer
***************************************

2. spacer 32.5|7747121|19|NC_017030|CRT matches to position: 69216-69234, mismatch: 2, identity: 0.895

ctgaccgccatcctgccca	CRISPR spacer
ctgaccgccatccggcgca	Protospacer
************* ** **

3. spacer 32.5|7747121|19|NC_017030|CRT matches to position: 7226172-7226190, mismatch: 2, identity: 0.895

ctgaccgccatcctgccca	CRISPR spacer
ctgaccgccatgccgccca	Protospacer
*********** *.*****

4. spacer 32.8|7747256|19|NC_017030|CRT matches to position: 1813765-1813783, mismatch: 2, identity: 0.895

cggacgtccgccgtcgttg	CRISPR spacer
cggaagtccaccgtcgttg	Protospacer
**** ****.*********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_LR134465	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence	116301-116325	2	0.92
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP050093	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b5, complete sequence	438610-438634	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP050082	Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence	620431-620455	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP050099	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence	376592-376616	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP050105	Rhizobium leguminosarum bv. trifolii strain 4B plasmid pRL4b6, complete sequence	597040-597064	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NC_008384	Rhizobium leguminosarum bv. viciae 3841 plasmid pRL11, complete sequence	594019-594043	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP025508	Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvB, complete sequence	506327-506351	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP050110	Rhizobium leguminosarum bv. trifolii strain 3B plasmid pRL3b4, complete sequence	597042-597066	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP048282	Rhizobium leguminosarum bv. viciae 248 plasmid pRle248d, complete sequence	467009-467033	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP054023	Rhizobium sp. JKLM12A2 plasmid pPR12A202, complete sequence	178779-178803	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP054029	Rhizobium sp. JKLM19E plasmid pPR19E02, complete sequence	230911-230935	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP054033	Rhizobium sp. JKLM13E plasmid pPR13E02, complete sequence	336032-336056	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP053208	Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence	522995-523019	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP050087	Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b5, complete sequence	505111-505135	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP018230	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed2, complete sequence	490115-490139	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP021016	Xanthomonas citri pv. phaseoli var. fuscans strain CFBP6991 plasmid pF, complete sequence	107483-107507	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP022667	Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR2, complete sequence	131253-131277	3	0.88
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP022566	Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK02, complete sequence	373924-373948	3	0.88
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	KT281796	Mycobacterium phage Zakhe101, complete genome	21139-21164	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	AY129335	Mycobacterium virus Corndog, complete genome	21868-21893	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MN428058	Mycobacterium phage Krili, complete genome	21137-21162	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MH020246	Mycobacterium phage SchoolBus, complete genome	21411-21436	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MT818418	Mycobacterium phage Shida, complete genome	21263-21288	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	NC_004685	Mycobacterium phage Corndog, complete genome	21868-21893	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	JN698993	Mycobacterium phage Firecracker, complete genome	21033-21058	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MH926062	Mycobacterium phage Vorrps, complete genome	21009-21034	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MG099943	Mycobacterium phage Familton, complete genome	21414-21439	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MG872838	Mycobacterium phage JangDynasty, complete genome	21503-21528	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MN585964	Mycobacterium phage Blessica, complete genome	21721-21746	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	KJ829260	Mycobacterium phage YungJamal, complete genome	21740-21765	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	NC_022057	Mycobacterium phage Catdawg, complete genome	21410-21435	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MT818425	Mycobacterium phage NiebruSaylor, complete genome	21009-21034	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	NC_022325	Mycobacterium phage Dylan, complete genome	21135-21160	3	0.885
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MN428052	Mycobacterium phage Smooch, complete genome	22551-22576	3	0.885
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NC_006569	Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence	364343-364367	4	0.84
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	586108-586132	4	0.84
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP024940	Paraburkholderia hospita strain mHSR1 plasmid pmHSR1_P, complete sequence	575287-575311	4	0.84
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP029833	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence	110667-110693	4	0.852
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP014769	Hymenobacter sp. PAMC 26554 plasmid unnamed1, complete sequence	142584-142610	4	0.852
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	NZ_CP050011	Citrobacter sp. Y3 plasmid unnamed2, complete sequence	22991-23016	4	0.846
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3694651-3694676	4	0.846
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	NZ_CP045770	Enterobacter cancerogenus strain MiY-F plasmid pCFSAN086183, complete sequence	88676-88701	4	0.846
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MN703407	Microbacterium phage Leaf, complete genome	77051-77076	4	0.846
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MN703414	Microbacterium phage Dewdrop, complete genome	77051-77076	4	0.846
NC_017030_9	9.1\|2188048\|25\|NC_017030\|CRISPRCasFinder	2188048-2188072	25	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	524799-524823	5	0.8
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NC_003037	Sinorhizobium meliloti 1021 plasmid pSymA, complete sequence	1177257-1177283	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NC_017327	Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence	1308193-1308219	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP009145	Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence	1283264-1283290	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NC_020062	Rhizobium tropici CIAT 899 plasmid pRtrCIAT899c, complete sequence	1905604-1905630	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP021801	Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence	1190503-1190529	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP021830	Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence	879622-879648	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP021824	Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence	1290690-1290716	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP021813	Sinorhizobium meliloti strain M270 plasmid psymA, complete sequence	131137-131163	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP021809	Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence	322313-322339	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP021217	Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence	913348-913374	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP019483	Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence	1029176-1029202	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP019486	Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence	983392-983418	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NC_020527	Sinorhizobium meliloti 2011 plasmid pSymA, complete sequence	1175595-1175621	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP019585	Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymA, complete sequence	202806-202832	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP021798	Sinorhizobium meliloti strain USDA1106 plasmid psymA, complete sequence	905433-905459	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP021827	Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence	336661-336687	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NC_017966	Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence	333831-333857	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP021819	Sinorhizobium meliloti strain M162 plasmid psymA, complete sequence	251822-251848	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NC_018683	Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence	303108-303134	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP026526	Sinorhizobium meliloti strain AK21 plasmid pSymA, complete sequence	473676-473702	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	KY676784	Streptomyces phage ToastyFinz, complete genome	31831-31857	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	175057-175083	5	0.815
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	NZ_CP020927	Sphingobium yanoikuyae strain SHJ plasmid pSES189, complete sequence	138774-138799	5	0.808
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	NZ_AP018520	Sphingobium sp. YG1 plasmid pYGP1, complete sequence	164156-164181	5	0.808
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	NC_012811	Methylorubrum extorquens AM1 megaplasmid, complete sequence	356393-356418	5	0.808
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MH248947	Streptomyces phage Yosif, complete genome	23543-23568	5	0.808
NC_017030_16	16.1\|5746561\|26\|NC_017030\|CRISPRCasFinder	5746561-5746586	26	MH248947	Streptomyces phage Yosif, complete genome	23567-23592	5	0.808
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP021082	Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence	351910-351943	5	0.853
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NZ_CP021332	Maritalea myrionectae strain HL2708#5 plasmid pHL2708Y3, complete sequence	43985-44012	5	0.821
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NC_015065	Granulicella tundricola MP5ACTX9 plasmid pACIX902, complete sequence	193170-193197	5	0.821
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	412569-412596	5	0.821
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NZ_LR134446	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 4, complete sequence	27336-27363	5	0.821
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NZ_CP020539	Sphingobium herbicidovorans strain MH plasmid pMSHV, complete sequence	848242-848269	5	0.821
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NZ_CP016453	Sphingobium sp. RAC03 plasmid pBSY17_1, complete sequence	396031-396058	5	0.821
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NC_011368	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence	935147-935174	5	0.821
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NZ_CP013635	Rhizobium sp. N324 plasmid pRspN324e, complete sequence	470392-470419	5	0.821
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NZ_CP035000	Rhizobium acidisoli strain FH23 plasmid pRapFH23b, complete sequence	322270-322297	5	0.821
NC_017030_38	38.1\|9545387\|27\|NC_017030\|CRISPRCasFinder	9545387-9545413	27	NZ_CP022369	Azospirillum sp. TSH58 plasmid TSH58_p05, complete sequence	439994-440020	5	0.815
NC_017030_38	38.1\|9545387\|27\|NC_017030\|CRISPRCasFinder	9545387-9545413	27	NZ_CP032326	Azospirillum brasilense strain MTCC4035 plasmid p5, complete sequence	21607-21633	5	0.815
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NC_008271	Rhodococcus jostii RHA1 plasmid pRHL3, complete sequence	214439-214465	6	0.778
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_HG938354	Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence	1429098-1429124	6	0.778
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_HG938356	Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence	1333791-1333817	6	0.778
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NC_023735	Rhodococcus phage ReqiPepy6, complete genome	24250-24276	6	0.778
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NC_023694	Rhodococcus phage ReqiPoco6, complete genome	26263-26289	6	0.778
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP023738	Methylosinus trichosporium OB3b plasmid pOB3b1, complete sequence	171465-171495	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_LT853887	Xanthomonas fragariae strain PD5205 plasmid pPD5205-21, complete sequence	19730-19760	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP016835	Xanthomonas fragariae isolate Fap29 plasmid pFap29-2, complete sequence	4838-4868	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_LT853881	Xanthomonas fragariae strain NBC2815 plasmid pNBC2815-21, complete sequence	19944-19974	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP006990	Rhizobium sp. IE4771 plasmid pRetIE4771d, complete sequence	254614-254644	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP017422	Arthrobacter sp. ZXY-2 plasmid pZXY21, complete sequence	110111-110141	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP046332	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed2	104783-104813	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	CP007644	Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803c, complete sequence	253803-253833	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	276182-276212	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP017750	Cupriavidus sp. USMAA2-4 plasmid unnamed1, complete sequence	33561-33591	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP017750	Cupriavidus sp. USMAA2-4 plasmid unnamed1, complete sequence	490759-490789	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP032520	Cupriavidus oxalaticus strain T2 plasmid unnamed1, complete sequence	16918-16948	6	0.806
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NC_006466	Cupriavidus metallidurans CH34 plasmid pMOL30, complete sequence	84207-84237	6	0.806
NC_017030_19	19.4\|6373017\|31\|NC_017030\|CRT	6373017-6373047	31	NC_021289	Burkholderia insecticola plasmid p1, complete sequence	707386-707416	6	0.806
NC_017030_19	19.4\|6373017\|31\|NC_017030\|CRT	6373017-6373047	31	NZ_CP006995	Methylobacterium sp. AMS5 plasmid pAMS5c, complete sequence	6032-6062	6	0.806
NC_017030_32	32.2\|7746950\|31\|NC_017030\|CRT	7746950-7746980	31	NZ_CP015623	Corynebacterium crudilactis strain JZ16 plasmid pCRULAC1, complete sequence	65306-65336	6	0.806
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP016820	Rhodococcus sp. p52 plasmid pDF02, complete sequence	30713-30746	6	0.824
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NC_015065	Granulicella tundricola MP5ACTX9 plasmid pACIX902, complete sequence	221741-221768	6	0.786
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	MK279853	Gordonia phage Gray, complete genome	40477-40504	6	0.786
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	MN586022	Gordonia phage Chidiebere, complete genome	40476-40503	6	0.786
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NZ_LR134465	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence	386417-386444	6	0.786
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	27294-27321	6	0.786
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	1019930-1019957	6	0.786
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NZ_CP012477	Arthrobacter sp. ERGS1:01 isolate water plasmid unnamed2, complete sequence	156658-156685	6	0.786
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NZ_CP005085	Sphingobium sp. TKS plasmid pTK1, complete sequence	225470-225497	6	0.786
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NZ_CP006990	Rhizobium sp. IE4771 plasmid pRetIE4771d, complete sequence	376529-376556	6	0.786
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NZ_CP021127	Rhizobium sp. Kim5 plasmid pRetKim5c, complete sequence	358808-358835	6	0.786
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NC_012855	Ralstonia pickettii 12D plasmid pRp12D01, complete sequence	328948-328975	6	0.786
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NZ_CP010801	Ralstonia mannitolilytica strain SN82F48 plasmid pRMAN01, complete sequence	78581-78608	6	0.786
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NZ_CP023526	Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence	16964-16991	6	0.786
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NZ_CP016451	Sinorhizobium sp. RAC02 plasmid pBSY16_2, complete sequence	204326-204353	6	0.786
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	MT521993	Gordonia phage RedWattleHog, complete genome	51772-51799	6	0.786
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	MN586040	Gordonia phage Stormageddon, complete genome	51755-51782	6	0.786
NC_017030_37	37.1\|9545246\|30\|NC_017030\|CRISPRCasFinder	9545246-9545275	30	MN862068	Brevundimonas phage vB_BsubS-Delta, complete genome	7733-7762	6	0.8
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP047177	Rathayibacter sp. VKM Ac-2759 plasmid unnamed1, complete sequence	116616-116649	7	0.794
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	JX042579	Mycobacterium virus MacnCheese, complete genome	38521-38554	7	0.794
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NC_022536	Rhizobium sp. IRBG74 plasmid IRBL74_p, complete sequence	136204-136230	7	0.741
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP053858	Rhizobium pusense strain 76 plasmid pR76, complete sequence	348335-348361	7	0.741
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	16955-16981	7	0.741
NC_017030_12	12.1\|2531941\|27\|NC_017030\|CRISPRCasFinder	2531941-2531967	27	NZ_CP027299	Streptomyces sp. SGAir0924 plasmid unnamed_5	217578-217604	7	0.741
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	128033-128063	7	0.774
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	MK937594	Gordonia phage Galadriel, complete genome	20869-20899	7	0.774
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NC_010373	Methylobacterium sp. 4-46 plasmid pM44601, complete sequence	17864-17897	7	0.794
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NC_010373	Methylobacterium sp. 4-46 plasmid pM44601, complete sequence	17954-17987	7	0.794
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NC_010373	Methylobacterium sp. 4-46 plasmid pM44601, complete sequence	18044-18077	7	0.794
NC_017030_32	32.6\|7747160\|28\|NC_017030\|CRT	7747160-7747187	28	NZ_CP049244	Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence	1094107-1094134	7	0.75
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NZ_CP009030	Xanthomonas citri pv. citri strain AW13 plasmid pXCAW58, complete sequence	52810-52837	7	0.75
NC_017030_32	32.7\|7747208\|28\|NC_017030\|CRT	7747208-7747235	28	NZ_CP009039	Xanthomonas citri pv. citri strain AW16 plasmid pXCAW58, complete sequence	52810-52837	7	0.75
NC_017030_37	37.1\|9545246\|30\|NC_017030\|CRISPRCasFinder	9545246-9545275	30	NC_008269	Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence	779084-779113	7	0.767
NC_017030_37	37.1\|9545246\|30\|NC_017030\|CRISPRCasFinder	9545246-9545275	30	NZ_CP035001	Rhizobium acidisoli strain FH23 plasmid pRapFH23c, complete sequence	391688-391717	7	0.767
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NC_007353	Sphingomonas sp. A1 plasmid pA1 DNA, complete sequence	41314-41347	8	0.765
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	JX469828	Uncultured bacterium plasmid pRSB223, complete sequence	18935-18968	8	0.765
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	JX469829	Uncultured bacterium plasmid pB1, complete sequence	10020-10053	8	0.765
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_MN366361	Bacterium plasmid pALTS33, complete sequence	10010-10043	8	0.765
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NC_003085	Myxococcus phage Mx8, complete genome	41045-41078	8	0.765
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	AF396866	Bacteriophage Mx8, complete genome	41045-41078	8	0.765
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_AP022607	Mycobacterium branderi strain JCM 12687 plasmid pJCM12687	303572-303605	8	0.765
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP010857	Marinovum algicola DG 898 plasmid pMaD2, complete sequence	174116-174149	8	0.765
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1171011-1171041	8	0.742
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	642523-642553	8	0.742
NC_017030_19	19.4\|6373017\|31\|NC_017030\|CRT	6373017-6373047	31	NZ_CP042820	Octadecabacter sp. SW4 plasmid pow41, complete sequence	106514-106544	8	0.742
NC_017030_19	19.4\|6373017\|31\|NC_017030\|CRT	6373017-6373047	31	NZ_CP010861	Marinovum algicola DG 898 plasmid pMaD6, complete sequence	61341-61371	8	0.742
NC_017030_32	32.2\|7746950\|31\|NC_017030\|CRT	7746950-7746980	31	NC_014718	Paraburkholderia rhizoxinica HKI 454 plasmid pBRH01, complete sequence	791947-791977	8	0.742
NC_017030_32	32.2\|7746950\|31\|NC_017030\|CRT	7746950-7746980	31	NZ_CP006991	Rhizobium sp. IE4771 plasmid pRetIE4771e, complete sequence	88471-88501	8	0.742
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP019037	Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence	145714-145747	8	0.765
NC_017030_37	37.1\|9545246\|30\|NC_017030\|CRISPRCasFinder	9545246-9545275	30	NZ_CP015811	Microbacterium chocolatum strain SIT 101 plasmid 1, complete sequence	5050-5079	8	0.733
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_LR134457	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 15, complete sequence	42069-42102	9	0.735
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP049041	Pseudohalocynthiibacter aestuariivivens strain RR4-35 plasmid pRR4-35_4, complete sequence	27453-27486	9	0.735
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	MN284895	Mycobacterium phage Marshawn, complete genome	37843-37876	9	0.735
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	5638952-5638985	9	0.735
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	KX683428	Mycobacterium phage TBond007, complete genome	37043-37076	9	0.735
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	MF373841	Mycobacterium phage Hurricane, complete genome	37512-37545	9	0.735
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	KR080206	Mycobacterium phage ShedlockHolmes, complete genome	37569-37602	9	0.735
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NC_042325	Mycobacterium virus Pixie, complete genome	37044-37077	9	0.735
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NC_026603	Mycobacterium phage Keshu, complete genome	37579-37612	9	0.735
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP054025	Rhizobium sp. JKLM12A2 plasmid pPR12A204, complete sequence	212680-212710	9	0.71
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NZ_CP054034	Rhizobium sp. JKLM13E plasmid pPR13E03, complete sequence	176115-176145	9	0.71
NC_017030_15	15.1\|5282080\|31\|NC_017030\|CRISPRCasFinder	5282080-5282110	31	NC_013858	Azospirillum sp. B510 plasmid pAB510d, complete sequence	403203-403233	9	0.71
NC_017030_25	25.1\|6829436\|34\|NC_017030\|CRISPRCasFinder	6829436-6829469	34	CP021183	Sphingomonas wittichii DC-6 plasmid pDC02, complete sequence	81122-81155	9	0.735
NC_017030_32	32.2\|7746950\|31\|NC_017030\|CRT	7746950-7746980	31	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	702221-702251	9	0.71
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	829191-829224	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP022363	Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence	756381-756414	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP007795	Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence	210308-210341	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP032341	Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence	112122-112155	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	430960-430993	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP016560	Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence	88217-88250	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP032323	Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence	896645-896678	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP012916	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence	127918-127951	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NC_042035	Mycobacterium phage Zemanar, complete sequence	31519-31552	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NC_022331	Mycobacterium phage Bane1, complete genome	31192-31225	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	KF279413	Mycobacterium phage Bane2, complete genome	31171-31204	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	KT021004	Thermobifida phage P1312, complete genome	38430-38463	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP054615	Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence	91167-91200	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	455629-455662	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP040819	Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence	522417-522450	9	0.735
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	1676732-1676765	9	0.735
NC_017030_37	37.1\|9545246\|30\|NC_017030\|CRISPRCasFinder	9545246-9545275	30	NZ_CP045361	Roseivivax sp. THAF40 plasmid pTHAF40_a, complete sequence	106319-106348	9	0.7
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	1129744-1129777	10	0.706
NC_017030_25	25.1\|6829436\|34\|NC_017030\|CRISPRCasFinder	6829436-6829469	34	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	916823-916856	10	0.706
NC_017030_25	25.1\|6829436\|34\|NC_017030\|CRISPRCasFinder	6829436-6829469	34	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	896299-896332	10	0.706
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP017563	Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence	912579-912612	10	0.706
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1910901-1910934	10	0.706
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1529712-1529745	10	0.706
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1817216-1817249	10	0.706
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NC_015409	Verrucosispora maris AB-18-032 plasmid pVMKU, complete sequence	463-496	10	0.706
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	KF954506	Mycobacterium phage Nyxis, complete genome	2952-2985	10	0.706
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	KX550441	Mycobacterium phage LittleGuy, complete genome	2949-2982	10	0.706
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1138244-1138277	10	0.706
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	LN997843	Streptomyces reticuli genome assembly TUE45, plasmid : II	352455-352488	10	0.706
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NC_007763	Rhizobium etli CFN 42 plasmid p42b, complete sequence	57214-57247	11	0.676
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP021025	Rhizobium sp. TAL182 plasmid pRetTAL182a, complete sequence	54187-54220	11	0.676
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP020907	Rhizobium etli strain NXC12 plasmid pRetNXC12a, complete sequence	57188-57221	11	0.676
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP013600	Rhizobium sp. N741 plasmid pRspN741e, complete sequence	166186-166219	11	0.676
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NC_021906	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1a, complete sequence	57225-57258	11	0.676
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP013504	Rhizobium esperanzae strain N561 plasmid pRspN561d, complete sequence	166186-166219	11	0.676
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP013510	Rhizobium sp. N1341 plasmid pRspN1341e, complete sequence	164627-164660	11	0.676
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP013521	Rhizobium sp. N113 plasmid pRspN113d, complete sequence	168874-168907	11	0.676
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP013494	Rhizobium sp. N6212 plasmid pRspN6212d, complete sequence	162992-163025	11	0.676
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP013512	Rhizobium sp. N1314 plasmid pRspN1314a, complete sequence	54186-54219	11	0.676
NC_017030_9	9.2\|2188102\|34\|NC_017030\|CRISPRCasFinder	2188102-2188135	34	NZ_CP013594	Rhizobium sp. N871 plasmid pRspN871d, complete sequence	166186-166219	11	0.676
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_LR536451	Methylocella tundrae isolate MTUNDRAET4 annotated genome plasmid 2	139618-139651	11	0.676
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_CP008954	Amycolatopsis japonica strain DSM 44213 plasmid pAmyja1, complete sequence	25331-25364	11	0.676
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	1100639-1100672	12	0.647
NC_017030_32	32.3\|7747001\|34\|NC_017030\|CRT	7747001-7747034	34	MK411746	Arthrobacter phage Sonali, complete genome	7891-7924	16	0.529

1. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_LR134465 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence) position: , mismatch: 2, identity: 0.92

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
cgcgcgtcgacgccgcccgcctcga	Protospacer
*************. **********

2. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP050093 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b5, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

3. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP050082 (Rhizobium leguminosarum bv. trifolii strain 31B plasmid pRL31b4, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

4. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP050099 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

5. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP050105 (Rhizobium leguminosarum bv. trifolii strain 4B plasmid pRL4b6, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

6. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NC_008384 (Rhizobium leguminosarum bv. viciae 3841 plasmid pRL11, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

7. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP025508 (Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvB, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

8. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP050110 (Rhizobium leguminosarum bv. trifolii strain 3B plasmid pRL3b4, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

9. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP048282 (Rhizobium leguminosarum bv. viciae 248 plasmid pRle248d, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

10. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP054023 (Rhizobium sp. JKLM12A2 plasmid pPR12A202, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

11. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP054029 (Rhizobium sp. JKLM19E plasmid pPR19E02, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

12. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP054033 (Rhizobium sp. JKLM13E plasmid pPR13E02, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

13. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP053208 (Rhizobium leguminosarum bv. trifolii TA1 plasmid pRltTA1B, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

14. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP050087 (Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b5, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

15. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP018230 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed2, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

16. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP021016 (Xanthomonas citri pv. phaseoli var. fuscans strain CFBP6991 plasmid pF, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
agcgcgtcgaggctcccggcctcga	Protospacer
 ********* ****** *******

17. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP022667 (Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR2, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccgccgcctcga	Protospacer
 ************.* *********

18. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP022566 (Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK02, complete sequence) position: , mismatch: 3, identity: 0.88

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
ggcgcgtcgacgcccaccgcctcga	Protospacer
 ************.* *********

19. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to KT281796 (Mycobacterium phage Zakhe101, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

20. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to AY129335 (Mycobacterium virus Corndog, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

21. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MN428058 (Mycobacterium phage Krili, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

22. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MH020246 (Mycobacterium phage SchoolBus, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

23. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MT818418 (Mycobacterium phage Shida, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

24. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to NC_004685 (Mycobacterium phage Corndog, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

25. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to JN698993 (Mycobacterium phage Firecracker, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

26. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MH926062 (Mycobacterium phage Vorrps, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

27. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MG099943 (Mycobacterium phage Familton, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

28. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MG872838 (Mycobacterium phage JangDynasty, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

29. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MN585964 (Mycobacterium phage Blessica, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

30. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to KJ829260 (Mycobacterium phage YungJamal, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

31. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to NC_022057 (Mycobacterium phage Catdawg, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

32. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MT818425 (Mycobacterium phage NiebruSaylor, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

33. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to NC_022325 (Mycobacterium phage Dylan, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

34. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MN428052 (Mycobacterium phage Smooch, complete genome) position: , mismatch: 3, identity: 0.885

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgccttc	Protospacer
************* *******.**.*

35. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NC_006569 (Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence) position: , mismatch: 4, identity: 0.84

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
accgcgtcgacgcccgccgcctcga	Protospacer
  ***********.* *********

36. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 4, identity: 0.84

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
gccgcgtcgacgcgcgccgcctcga	Protospacer
  *********** * *********

37. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP024940 (Paraburkholderia hospita strain mHSR1 plasmid pmHSR1_P, complete sequence) position: , mismatch: 4, identity: 0.84

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
tccgcgtcgacgctcccctcgtcga	Protospacer
. **************** * ****

38. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP029833 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence) position: , mismatch: 4, identity: 0.852

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
tcacccgcaccgccgcgcatgccaccg	Protospacer
.*******.****** **********

39. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP014769 (Hymenobacter sp. PAMC 26554 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.852

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
ccgaccacgccgccgagcacgccaccc	Protospacer
**. **.************.*******

40. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to NZ_CP050011 (Citrobacter sp. Y3 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.846

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgcgctgcggcttcgtcatc	Protospacer
******** *** ********** .*

41. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 4, identity: 0.846

cgggcttgggctccggcttcgtctcc	CRISPR spacer
tgggcgtgggctccgccttcgtcttc	Protospacer
.**** ********* ********.*

42. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to NZ_CP045770 (Enterobacter cancerogenus strain MiY-F plasmid pCFSAN086183, complete sequence) position: , mismatch: 4, identity: 0.846

cgggcttgggctccggcttcgtctcc	CRISPR spacer
agggcttgcgctgcggcttcgtcttc	Protospacer
 ******* *** ***********.*

43. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MN703407 (Microbacterium phage Leaf, complete genome) position: , mismatch: 4, identity: 0.846

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttcggctcgggcttcgtcggc	Protospacer
******* ***** *********  *

44. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MN703414 (Microbacterium phage Dewdrop, complete genome) position: , mismatch: 4, identity: 0.846

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttcggctcgggcttcgtcggc	Protospacer
******* ***** *********  *

45. spacer 9.1|2188048|25|NC_017030|CRISPRCasFinder matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.8

cgcgcgtcgacgctccccgcctcga	CRISPR spacer
tcccggtcgacgctccccgcctcgc	Protospacer
. *  *******************

46. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NC_003037 (Sinorhizobium meliloti 1021 plasmid pSymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

47. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NC_017327 (Sinorhizobium meliloti SM11 plasmid pSmeSM11c, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

48. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP009145 (Sinorhizobium meliloti strain RMO17 plasmid pSymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

49. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NC_020062 (Rhizobium tropici CIAT 899 plasmid pRtrCIAT899c, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
acggccgcgccgccgatcatgccacca	Protospacer
 *. ************ *********

50. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP021801 (Sinorhizobium meliloti strain USDA1021 plasmid psymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

51. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP021830 (Sinorhizobium meliloti strain HM006 plasmid psymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccaagcatgccaccg	Protospacer
 *  **********.***********

52. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP021824 (Sinorhizobium meliloti strain KH46 plasmid psymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

53. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP021813 (Sinorhizobium meliloti strain M270 plasmid psymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

54. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP021809 (Sinorhizobium meliloti strain Rm41 plasmid psymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

55. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP021217 (Sinorhizobium meliloti RU11/001 plasmid pSymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

56. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP019483 (Sinorhizobium meliloti strain B401 plasmid pSymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

57. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP019486 (Sinorhizobium meliloti strain B399 plasmid pSymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

58. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NC_020527 (Sinorhizobium meliloti 2011 plasmid pSymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

59. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP019585 (Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

60. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP021798 (Sinorhizobium meliloti strain USDA1106 plasmid psymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

61. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP021827 (Sinorhizobium meliloti strain KH35c plasmid psymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

62. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NC_017966 (Tistrella mobilis KA081020-065 plasmid pTM2, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
tgacccgcgccgccgagcgtgccgccg	Protospacer
. ****************.****.**

63. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP021819 (Sinorhizobium meliloti strain M162 plasmid psymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

64. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NC_018683 (Sinorhizobium meliloti Rm41 plasmid pSYMA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

65. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP026526 (Sinorhizobium meliloti strain AK21 plasmid pSymA, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accaccgcgccgccgagcatgccgccg	Protospacer
 *  *******************.**

66. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to KY676784 (Streptomyces phage ToastyFinz, complete genome) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
accgccgcgccgccgagcaggccgccc	Protospacer
 *  *************** ***.***

67. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 5, identity: 0.815

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
tcgcccgcgccgccgagcaggccgccg	Protospacer
.*.**************** ***.**

68. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to NZ_CP020927 (Sphingobium yanoikuyae strain SHJ plasmid pSES189, complete sequence) position: , mismatch: 5, identity: 0.808

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgtgcag	Protospacer
************* ******** .

69. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to NZ_AP018520 (Sphingobium sp. YG1 plasmid pYGP1, complete sequence) position: , mismatch: 5, identity: 0.808

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcgtgcag	Protospacer
************* ******** .

70. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to NC_012811 (Methylorubrum extorquens AM1 megaplasmid, complete sequence) position: , mismatch: 5, identity: 0.808

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cacagttgggctgcggcttcgtctcc	Protospacer
*. . ******* *************

71. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MH248947 (Streptomyces phage Yosif, complete genome) position: , mismatch: 5, identity: 0.808

cgggcttgggctccggcttcgtctcc	CRISPR spacer
cgggcttgggctcgggcttcggagcg	Protospacer
************* *******   *

72. spacer 16.1|5746561|26|NC_017030|CRISPRCasFinder matches to MH248947 (Streptomyces phage Yosif, complete genome) position: , mismatch: 5, identity: 0.808

cgggcttgggctccggcttcgtctcc	CRISPR spacer
gaggcttgggctcgggcttcggctcg	Protospacer
 .*********** ******* ***

73. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP021082 (Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence) position: , mismatch: 5, identity: 0.853

gccctgaccaccgtcaccgccgccgtcgctggga---	CRISPR spacer
gccctgaccaccctcaccgccgccctc---gggatcg	Protospacer
************ *********** **   ****

74. spacer 32.6|7747160|28|NC_017030|CRT matches to NZ_CP021332 (Maritalea myrionectae strain HL2708#5 plasmid pHL2708Y3, complete sequence) position: , mismatch: 5, identity: 0.821

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
cgcgccgccggccgcgccaccatccaca	Protospacer
 ** ****** **************. *

75. spacer 32.6|7747160|28|NC_017030|CRT matches to NC_015065 (Granulicella tundricola MP5ACTX9 plasmid pACIX902, complete sequence) position: , mismatch: 5, identity: 0.821

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
ggaaccgccgtccacgccaccatccagg	Protospacer
**  *********.***********.*.

76. spacer 32.6|7747160|28|NC_017030|CRT matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.821

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
gacgccgccgtccgcgccaccgcccggc	Protospacer
*.* *****************..****

77. spacer 32.6|7747160|28|NC_017030|CRT matches to NZ_LR134446 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 4, complete sequence) position: , mismatch: 5, identity: 0.821

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
ggccccgccgtccgcgccgccgccctca	Protospacer
******************.**..**  *

78. spacer 32.6|7747160|28|NC_017030|CRT matches to NZ_CP020539 (Sphingobium herbicidovorans strain MH plasmid pMSHV, complete sequence) position: , mismatch: 5, identity: 0.821

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
gcgcccgccgcccgcgccatcatccgaa	Protospacer
*  *******.********.******.*

79. spacer 32.7|7747208|28|NC_017030|CRT matches to NZ_CP016453 (Sphingobium sp. RAC03 plasmid pBSY17_1, complete sequence) position: , mismatch: 5, identity: 0.821

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
cagcggcgtgccgccatcacccttcgcc	Protospacer
* *************.*********

80. spacer 32.7|7747208|28|NC_017030|CRT matches to NC_011368 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG201, complete sequence) position: , mismatch: 5, identity: 0.821

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
ctcgatcgtgccgccgtaacccttctgg	Protospacer
**  . *********** **********

81. spacer 32.7|7747208|28|NC_017030|CRT matches to NZ_CP013635 (Rhizobium sp. N324 plasmid pRspN324e, complete sequence) position: , mismatch: 5, identity: 0.821

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
ctcgatcgtgccgccgtaacccttctgg	Protospacer
**  . *********** **********

82. spacer 32.7|7747208|28|NC_017030|CRT matches to NZ_CP035000 (Rhizobium acidisoli strain FH23 plasmid pRapFH23b, complete sequence) position: , mismatch: 5, identity: 0.821

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
ctcgatcgtgccgccgtaacccttctgg	Protospacer
**  . *********** **********

83. spacer 38.1|9545387|27|NC_017030|CRISPRCasFinder matches to NZ_CP022369 (Azospirillum sp. TSH58 plasmid TSH58_p05, complete sequence) position: , mismatch: 5, identity: 0.815

atcgtccgtgggctgttcctcgttgga	CRISPR spacer
cgagtccgtggactgttcctcggtgga	Protospacer
   ********.********** ****

84. spacer 38.1|9545387|27|NC_017030|CRISPRCasFinder matches to NZ_CP032326 (Azospirillum brasilense strain MTCC4035 plasmid p5, complete sequence) position: , mismatch: 5, identity: 0.815

atcgtccgtgggctgttcctcgttgga	CRISPR spacer
cgagtccgtggactgttcctcggtgga	Protospacer
   ********.********** ****

85. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NC_008271 (Rhodococcus jostii RHA1 plasmid pRHL3, complete sequence) position: , mismatch: 6, identity: 0.778

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
ccacccgcgccgccgagcagcttcgcc	Protospacer
*******************  ..  **

86. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_HG938354 (Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence) position: , mismatch: 6, identity: 0.778

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
tcacccgcgtcgccgagcatggcatga	Protospacer
.********.*********** **.

87. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_HG938356 (Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence) position: , mismatch: 6, identity: 0.778

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
tcacccgcgtcgccgagcatggcatga	Protospacer
.********.*********** **.

88. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NC_023735 (Rhodococcus phage ReqiPepy6, complete genome) position: , mismatch: 6, identity: 0.778

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
cagaatgcgccgccgagcatgccatcc	Protospacer
* .  .******************.**

89. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NC_023694 (Rhodococcus phage ReqiPoco6, complete genome) position: , mismatch: 6, identity: 0.778

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
cagaatgcgccgccgagcatgccatcc	Protospacer
* .  .******************.**

90. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP023738 (Methylosinus trichosporium OB3b plasmid pOB3b1, complete sequence) position: , mismatch: 6, identity: 0.806

cgccggctccggctcccggcgcgaccgtccc--	CRISPR spacer
cgccggctccgcctcccggcgcg--cggcgagg	Protospacer
*********** ***********  ** *

91. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_LT853887 (Xanthomonas fragariae strain PD5205 plasmid pPD5205-21, complete sequence) position: , mismatch: 6, identity: 0.806

--cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
cgtgctgg--ccggctccctgcgcgaccgcccc	Protospacer
  .**.**  ********* *********.***

92. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP016835 (Xanthomonas fragariae isolate Fap29 plasmid pFap29-2, complete sequence) position: , mismatch: 6, identity: 0.806

--cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
cgtgctgg--ccggctccctgcgcgaccgcccc	Protospacer
  .**.**  ********* *********.***

93. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_LT853881 (Xanthomonas fragariae strain NBC2815 plasmid pNBC2815-21, complete sequence) position: , mismatch: 6, identity: 0.806

--cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
cgtgctgg--ccggctccctgcgcgaccgcccc	Protospacer
  .**.**  ********* *********.***

94. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP006990 (Rhizobium sp. IE4771 plasmid pRetIE4771d, complete sequence) position: , mismatch: 6, identity: 0.806

cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
cgccggcttcggctcccgccgcgccttgccc	Protospacer
********.********* **** *.  ***

95. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP017422 (Arthrobacter sp. ZXY-2 plasmid pZXY21, complete sequence) position: , mismatch: 6, identity: 0.806

cgccggctccggctcccggcgcg-accgtccc	CRISPR spacer
cgccggcggcggctcccggcgcgcatcggca-	Protospacer
*******  ************** *.** *

96. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP046332 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed2) position: , mismatch: 6, identity: 0.806

cgccggctccggctcccggcgcg-accgtccc	CRISPR spacer
cgccggctccagctcacggcgcgtaatggcc-	Protospacer
**********.**** ******* * .* **

97. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to CP007644 (Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803c, complete sequence) position: , mismatch: 6, identity: 0.806

cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
cgccggcttcggctcccgccgcgccttgccc	Protospacer
********.********* **** *.  ***

98. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.806

cgccggctccggctcccggcgcg-accgtccc	CRISPR spacer
cgccggctccagctcacggcgcgtaatggcc-	Protospacer
**********.**** ******* * .* **

99. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP017750 (Cupriavidus sp. USMAA2-4 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.806

cgccggctccggctcccggcgcg-accgtccc	CRISPR spacer
cgccggctccagctcacggcgcgtaatggcc-	Protospacer
**********.**** ******* * .* **

100. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP017750 (Cupriavidus sp. USMAA2-4 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.806

cgccggctccggctcccggcgcg-accgtccc	CRISPR spacer
cgccggctccagctcacggcgcgtaatggcc-	Protospacer
**********.**** ******* * .* **

101. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP032520 (Cupriavidus oxalaticus strain T2 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.806

cgccggctccggctcccggcgcg-accgtccc	CRISPR spacer
cgccggctccagctcacggcgcgtaatggcc-	Protospacer
**********.**** ******* * .* **

102. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NC_006466 (Cupriavidus metallidurans CH34 plasmid pMOL30, complete sequence) position: , mismatch: 6, identity: 0.806

cgccggctccggctcccggcgcg-accgtccc	CRISPR spacer
cgccggctccagctcacggcgcgtaatggcc-	Protospacer
**********.**** ******* * .* **

103. spacer 19.4|6373017|31|NC_017030|CRT matches to NC_021289 (Burkholderia insecticola plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.806

acctccctctcggaggacgaggagcgcgcgc	CRISPR spacer
gcggcgctcgcggaggacgaggtgcgcgcgc	Protospacer
.*  * *** ************ ********

104. spacer 19.4|6373017|31|NC_017030|CRT matches to NZ_CP006995 (Methylobacterium sp. AMS5 plasmid pAMS5c, complete sequence) position: , mismatch: 6, identity: 0.806

acctccctctcggaggacgaggagcgcgcgc-	CRISPR spacer
ctctccctgtcggaggacgaggaccg-gcgaa	Protospacer
 .****** ************** ** ***

105. spacer 32.2|7746950|31|NC_017030|CRT matches to NZ_CP015623 (Corynebacterium crudilactis strain JZ16 plasmid pCRULAC1, complete sequence) position: , mismatch: 6, identity: 0.806

-gtccgcgccaccatcgcgcgagtcgccttcg	CRISPR spacer
agcgcacg-caccatcgcacgagtcgccatcg	Protospacer
 *. *.** *********.********* ***

106. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP016820 (Rhodococcus sp. p52 plasmid pDF02, complete sequence) position: , mismatch: 6, identity: 0.824

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
gccctgaccaccgccaccgccgccggcgccgatc	Protospacer
*************.*********** ***.*.

107. spacer 32.6|7747160|28|NC_017030|CRT matches to NC_015065 (Granulicella tundricola MP5ACTX9 plasmid pACIX902, complete sequence) position: , mismatch: 6, identity: 0.786

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
ctccccgccttccgcgccaccatcacgg	Protospacer
  ******* **************  *.

108. spacer 32.6|7747160|28|NC_017030|CRT matches to MK279853 (Gordonia phage Gray, complete genome) position: , mismatch: 6, identity: 0.786

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
ggccccgccgaccgcgccaccaccaccg	Protospacer
********** ***********.*   .

109. spacer 32.6|7747160|28|NC_017030|CRT matches to MN586022 (Gordonia phage Chidiebere, complete genome) position: , mismatch: 6, identity: 0.786

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
ggccccgccgaccgcgccaccaccaccg	Protospacer
********** ***********.*   .

110. spacer 32.6|7747160|28|NC_017030|CRT matches to NZ_LR134465 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence) position: , mismatch: 6, identity: 0.786

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
gtcgacgccgtccgcgccaccgtccgcc	Protospacer
* *  ****************.****

111. spacer 32.6|7747160|28|NC_017030|CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 6, identity: 0.786

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
tggcccgccgtccgcgccagaatccgat	Protospacer
 * ****************  *****.

112. spacer 32.6|7747160|28|NC_017030|CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 6, identity: 0.786

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
tggcccgccgtccgcgccagaatccgat	Protospacer
 * ****************  *****.

113. spacer 32.6|7747160|28|NC_017030|CRT matches to NZ_CP012477 (Arthrobacter sp. ERGS1:01 isolate water plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.786

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
agcgacgccgtccgcgccaccacccgcg	Protospacer
.**  *****************.*** .

114. spacer 32.6|7747160|28|NC_017030|CRT matches to NZ_CP005085 (Sphingobium sp. TKS plasmid pTK1, complete sequence) position: , mismatch: 6, identity: 0.786

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
gcgccagccgtccgcgccatcatccgcg	Protospacer
*  ** *************.****** .

115. spacer 32.7|7747208|28|NC_017030|CRT matches to NZ_CP006990 (Rhizobium sp. IE4771 plasmid pRetIE4771d, complete sequence) position: , mismatch: 6, identity: 0.786

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
ttcgatcgtgccgccgtaacccttctgg	Protospacer
.*  . *********** **********

116. spacer 32.7|7747208|28|NC_017030|CRT matches to NZ_CP021127 (Rhizobium sp. Kim5 plasmid pRetKim5c, complete sequence) position: , mismatch: 6, identity: 0.786

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
ttcgatcgtgccgccgtaacccttctgg	Protospacer
.*  . *********** **********

117. spacer 32.7|7747208|28|NC_017030|CRT matches to NC_012855 (Ralstonia pickettii 12D plasmid pRp12D01, complete sequence) position: , mismatch: 6, identity: 0.786

ctgcggcgtgccgccgtcaccct---tctgg	CRISPR spacer
ctgcggcctgccgccgtcaccgcagatc---	Protospacer
******* ************* .   **

118. spacer 32.7|7747208|28|NC_017030|CRT matches to NZ_CP010801 (Ralstonia mannitolilytica strain SN82F48 plasmid pRMAN01, complete sequence) position: , mismatch: 6, identity: 0.786

ctgcggcgtgccgccgtcaccct---tctgg	CRISPR spacer
ctgcggcctgccgccgtcaccgcagatc---	Protospacer
******* ************* .   **

119. spacer 32.7|7747208|28|NC_017030|CRT matches to NZ_CP023526 (Cedecea neteri strain FDAARGOS_392 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.786

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
ccagagcgtgccggcctcacccttctgg	Protospacer
*.. .******** * ************

120. spacer 32.7|7747208|28|NC_017030|CRT matches to NZ_CP016451 (Sinorhizobium sp. RAC02 plasmid pBSY16_2, complete sequence) position: , mismatch: 6, identity: 0.786

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
ctgcggcgtgccgccgacaccgatccat	Protospacer
**************** ****  **..

121. spacer 32.7|7747208|28|NC_017030|CRT matches to MT521993 (Gordonia phage RedWattleHog, complete genome) position: , mismatch: 6, identity: 0.786

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
cagcggggtgccgccgtcaccctcgctg	Protospacer
* **** ****************. . *

122. spacer 32.7|7747208|28|NC_017030|CRT matches to MN586040 (Gordonia phage Stormageddon, complete genome) position: , mismatch: 6, identity: 0.786

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
cagcggggtgccgccgtcaccctcgctg	Protospacer
* **** ****************. . *

123. spacer 37.1|9545246|30|NC_017030|CRISPRCasFinder matches to MN862068 (Brevundimonas phage vB_BsubS-Delta, complete genome) position: , mismatch: 6, identity: 0.8

atccgtcgcggaaccggcatccgtcgaagt	CRISPR spacer
agcctccgccgaaccggcacccgtcgaagc	Protospacer
* ** .*** *********.*********.

124. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP047177 (Rathayibacter sp. VKM Ac-2759 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.794

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
acgtagaagcccacggcgacgacgaggccggcga	Protospacer
.*   ******************** *** ***.

125. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to JX042579 (Mycobacterium virus MacnCheese, complete genome) position: , mismatch: 7, identity: 0.794

----gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tgcggcc----cgcccgcggcgacgacgacgcccgcag	Protospacer
    ***     ****.*******************.*

126. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NC_022536 (Rhizobium sp. IRBG74 plasmid IRBL74_p, complete sequence) position: , mismatch: 7, identity: 0.741

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
tcacccgcgccggcgagcatgcggaga	Protospacer
.*********** ********* .

127. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP053858 (Rhizobium pusense strain 76 plasmid pR76, complete sequence) position: , mismatch: 7, identity: 0.741

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
tcacccgcgccggcgagcatgcggaga	Protospacer
.*********** ********* .

128. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.741

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
tggaccgcgccgccgagcatgccggca	Protospacer
. . *******************. *

129. spacer 12.1|2531941|27|NC_017030|CRISPRCasFinder matches to NZ_CP027299 (Streptomyces sp. SGAir0924 plasmid unnamed_5) position: , mismatch: 7, identity: 0.741

ccacccgcgccgccgagcatgccaccc	CRISPR spacer
aggagagcgccgccgagcatgccgccc	Protospacer
  .   *****************.***

130. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.774

cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
tgcgtccgccggcgcccggcgggaccgtccc	Protospacer
.**   * ***** ******* *********

131. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to MK937594 (Gordonia phage Galadriel, complete genome) position: , mismatch: 7, identity: 0.774

cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
ccggggtaccggcacacggcgcgaccgtccc	Protospacer
*   **. ***** * ***************

132. spacer 32.3|7747001|34|NC_017030|CRT matches to NC_010373 (Methylobacterium sp. 4-46 plasmid pM44601, complete sequence) position: , mismatch: 7, identity: 0.794

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
gccgcggacaccgtcaccgccgccgccgccgggg	Protospacer
*** .*. *****************.***.***.

133. spacer 32.3|7747001|34|NC_017030|CRT matches to NC_010373 (Methylobacterium sp. 4-46 plasmid pM44601, complete sequence) position: , mismatch: 7, identity: 0.794

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
gccgcggacaccgtcaccgccgccgccgccgggg	Protospacer
*** .*. *****************.***.***.

134. spacer 32.3|7747001|34|NC_017030|CRT matches to NC_010373 (Methylobacterium sp. 4-46 plasmid pM44601, complete sequence) position: , mismatch: 7, identity: 0.794

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
gccgcggacaccgtcaccgccgccgccgccgggg	Protospacer
*** .*. *****************.***.***.

135. spacer 32.6|7747160|28|NC_017030|CRT matches to NZ_CP049244 (Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.75

ggccccgccgtccgcgccaccatccgga	CRISPR spacer
gcgaccgccgtgcgcgccaccatccttg	Protospacer
*   ******* *************  .

136. spacer 32.7|7747208|28|NC_017030|CRT matches to NZ_CP009030 (Xanthomonas citri pv. citri strain AW13 plasmid pXCAW58, complete sequence) position: , mismatch: 7, identity: 0.75

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
ctgcggcgtgccgccgacaacctcaaac	Protospacer
**************** ** ***.  .

137. spacer 32.7|7747208|28|NC_017030|CRT matches to NZ_CP009039 (Xanthomonas citri pv. citri strain AW16 plasmid pXCAW58, complete sequence) position: , mismatch: 7, identity: 0.75

ctgcggcgtgccgccgtcacccttctgg	CRISPR spacer
ctgcggcgtgccgccgacaacctcaaac	Protospacer
**************** ** ***.  .

138. spacer 37.1|9545246|30|NC_017030|CRISPRCasFinder matches to NC_008269 (Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence) position: , mismatch: 7, identity: 0.767

atccgtcgcggaaccggcatccgtcgaagt	CRISPR spacer
cgaagtcccggatccggcatccgtcgaact	Protospacer
    *** **** *************** *

139. spacer 37.1|9545246|30|NC_017030|CRISPRCasFinder matches to NZ_CP035001 (Rhizobium acidisoli strain FH23 plasmid pRapFH23c, complete sequence) position: , mismatch: 7, identity: 0.767

atccgtcgcggaaccggcatccgtcgaagt	CRISPR spacer
attcgtcgcggaaccggcagccggctgatg	Protospacer
**.**************** *** * .*

140. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NC_007353 (Sphingomonas sp. A1 plasmid pA1 DNA, complete sequence) position: , mismatch: 8, identity: 0.765

-gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tggctc-aagctcacggcggcgacgacgcccgaca	Protospacer
 * * * ****.*******.************  .

141. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to JX469828 (Uncultured bacterium plasmid pRSB223, complete sequence) position: , mismatch: 8, identity: 0.765

-gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tggctc-aagctcacggcggcgacgacgcccgaca	Protospacer
 * * * ****.*******.************  .

142. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to JX469829 (Uncultured bacterium plasmid pB1, complete sequence) position: , mismatch: 8, identity: 0.765

-gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tggctc-aagctcacggcggcgacgacgcccgaca	Protospacer
 * * * ****.*******.************  .

143. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_MN366361 (Bacterium plasmid pALTS33, complete sequence) position: , mismatch: 8, identity: 0.765

-gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tggctc-aagctcacggcggcgacgacgcccgaca	Protospacer
 * * * ****.*******.************  .

144. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NC_003085 (Myxococcus phage Mx8, complete genome) position: , mismatch: 8, identity: 0.765

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccagcgacgcccacggcgatgacgacgccgctgg	Protospacer
 * .*** ***********.*********  .**

145. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to AF396866 (Bacteriophage Mx8, complete genome) position: , mismatch: 8, identity: 0.765

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccagcgacgcccacggcgatgacgacgccgctgg	Protospacer
 * .*** ***********.*********  .**

146. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_AP022607 (Mycobacterium branderi strain JCM 12687 plasmid pJCM12687) position: , mismatch: 8, identity: 0.765

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
agcacgcagcccacgacgacgacgacgaaaccgg	Protospacer
. **** ********.***********    ***

147. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP010857 (Marinovum algicola DG 898 plasmid pMaD2, complete sequence) position: , mismatch: 8, identity: 0.765

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tccacgaagcccacggcgatgccgatggttgtgg	Protospacer
 ******************.* ***.* ..*.**

148. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 8, identity: 0.742

cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
gtccggctgcggcacccggcgcgacaggtca	Protospacer
  ****** **** *********** * .*

149. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 8, identity: 0.742

cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
gtccggctgcggcacccggcgcgacaggtca	Protospacer
  ****** **** *********** * .*

150. spacer 19.4|6373017|31|NC_017030|CRT matches to NZ_CP042820 (Octadecabacter sp. SW4 plasmid pow41, complete sequence) position: , mismatch: 8, identity: 0.742

acctccctctcggaggacgaggagcgcgcgc	CRISPR spacer
attggtccctcggaggacgagttgcgcgcgc	Protospacer
*..  .*.*************  ********

151. spacer 19.4|6373017|31|NC_017030|CRT matches to NZ_CP010861 (Marinovum algicola DG 898 plasmid pMaD6, complete sequence) position: , mismatch: 8, identity: 0.742

acctccctctcggaggacgaggagcgcgcgc	CRISPR spacer
attggtccctcggaggacgagttgcgcgcgc	Protospacer
*..  .*.*************  ********

152. spacer 32.2|7746950|31|NC_017030|CRT matches to NC_014718 (Paraburkholderia rhizoxinica HKI 454 plasmid pBRH01, complete sequence) position: , mismatch: 8, identity: 0.742

gtccgcgccaccatcgcgcgagtcgccttcg	CRISPR spacer
ctccgcgccgccatcgcgcaagtcgtcgcga	Protospacer
 ********.*********.*****.* . .

153. spacer 32.2|7746950|31|NC_017030|CRT matches to NZ_CP006991 (Rhizobium sp. IE4771 plasmid pRetIE4771e, complete sequence) position: , mismatch: 8, identity: 0.742

gtccgcgccaccatcgcgcgagtcgccttcg	CRISPR spacer
gctcgcgccaccgtcgcgcgagtagccgaac	Protospacer
*..*********.********** ***

154. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP019037 (Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

gccctgaccaccgtcaccgccgccgt-cgctggga	CRISPR spacer
accctgaacaccgtcaccgcagccgcgcaatgcg-	Protospacer
.****** ************ ****. *. ** *

155. spacer 37.1|9545246|30|NC_017030|CRISPRCasFinder matches to NZ_CP015811 (Microbacterium chocolatum strain SIT 101 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.733

atccgtcgcggaaccggcatccgtcgaagt	CRISPR spacer
caccgtcgcggagccggcatccatcgcccc	Protospacer
  **********.*********.***   .

156. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_LR134457 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 15, complete sequence) position: , mismatch: 9, identity: 0.735

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tcggcctcgcccacggcgacgacgccgcgcgcga	Protospacer
 * .*   **************** *** ****.

157. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP049041 (Pseudohalocynthiibacter aestuariivivens strain RR4-35 plasmid pRR4-35_4, complete sequence) position: , mismatch: 9, identity: 0.735

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
acaccctcgcccacctcgacgacgacgcccgcgc	Protospacer
.*  *   ******  *****************

158. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to MN284895 (Mycobacterium phage Marshawn, complete genome) position: , mismatch: 9, identity: 0.735

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tccggccagcacgcggcgacgacgacgcccgcac	Protospacer
 **.   *** *.*******************.

159. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 9, identity: 0.735

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
agcaccgctcccacggcggcgacgacgcacgcgc	Protospacer
. *** .  *********.********* ****

160. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to KX683428 (Mycobacterium phage TBond007, complete genome) position: , mismatch: 9, identity: 0.735

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tgcgcccggcacgcggcgacgacgacgcccgcag	Protospacer
  *.*  .** *.*******************.*

161. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to MF373841 (Mycobacterium phage Hurricane, complete genome) position: , mismatch: 9, identity: 0.735

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tgcgcccggcgcgcggcgacgacgacgcccgcag	Protospacer
  *.*  .** *.*******************.*

162. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to KR080206 (Mycobacterium phage ShedlockHolmes, complete genome) position: , mismatch: 9, identity: 0.735

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tgcgcccggcacgcggcgacgacgacgcccgcag	Protospacer
  *.*  .** *.*******************.*

163. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NC_042325 (Mycobacterium virus Pixie, complete genome) position: , mismatch: 9, identity: 0.735

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tgcgcccggcacgcggcgacgacgacgcccgcag	Protospacer
  *.*  .** *.*******************.*

164. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NC_026603 (Mycobacterium phage Keshu, complete genome) position: , mismatch: 9, identity: 0.735

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
tgcgcccggcgcgcggcgacgacgacgcccgcag	Protospacer
  *.*  .** *.*******************.*

165. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP054025 (Rhizobium sp. JKLM12A2 plasmid pPR12A204, complete sequence) position: , mismatch: 9, identity: 0.71

cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
ttgcggccccggctcccggcgcgacatggac	Protospacer
.  ****.*****************     *

166. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NZ_CP054034 (Rhizobium sp. JKLM13E plasmid pPR13E03, complete sequence) position: , mismatch: 9, identity: 0.71

cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
ttgcggccccggctcccggcgcgacatggac	Protospacer
.  ****.*****************     *

167. spacer 15.1|5282080|31|NC_017030|CRISPRCasFinder matches to NC_013858 (Azospirillum sp. B510 plasmid pAB510d, complete sequence) position: , mismatch: 9, identity: 0.71

cgccggctccggctcccggcgcgaccgtccc	CRISPR spacer
agccggctccggctccgggggcgaacaggat	Protospacer
 *************** ** **** *.   .

168. spacer 25.1|6829436|34|NC_017030|CRISPRCasFinder matches to CP021183 (Sphingomonas wittichii DC-6 plasmid pDC02, complete sequence) position: , mismatch: 9, identity: 0.735

aacaggttccgggacaccgccgccggtaccacgg	CRISPR spacer
ctcaggatccgtgacaccgccgccggtattattc	Protospacer
  **** **** ****************..*.

169. spacer 32.2|7746950|31|NC_017030|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 9, identity: 0.71

gtccgcgccaccatcgcgcgagtcgccttcg	CRISPR spacer
ggggtcgccaccatcgcgggcgtcgcctcgc	Protospacer
*    ************* * *******.

170. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
ctcctgaccactgccaccgccgccgtcgtcgtcc	Protospacer
 .*********.*.**************..*

171. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP022363 (Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accctgacgaccgtcaccgccgccttcctcgccc	Protospacer
.******* *************** ** ..*

172. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP007795 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accctgacgaccgtcaccgccgccttcctcgccc	Protospacer
.******* *************** ** ..*

173. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP032341 (Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accctgacgaccgtcaccgccgccttcctcgccc	Protospacer
.******* *************** ** ..*

174. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
ctcctgaccactgccaccgccgccgtcgtcgtcc	Protospacer
 .*********.*.**************..*

175. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP016560 (Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
ctcctgaccactgccaccgccgccgtcgtcgtcc	Protospacer
 .*********.*.**************..*

176. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP032323 (Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accctgacgaccgtcaccgccgccttcctcgcct	Protospacer
.******* *************** ** ..*

177. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP012916 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accctgacgaccgtcaccgccgccttcctcgccc	Protospacer
.******* *************** ** ..*

178. spacer 32.3|7747001|34|NC_017030|CRT matches to NC_042035 (Mycobacterium phage Zemanar, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
tacgtgaccaccgccaccgccgccgttgccgccg	Protospacer
  * *********.************.**.*  .

179. spacer 32.3|7747001|34|NC_017030|CRT matches to NC_022331 (Mycobacterium phage Bane1, complete genome) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
tacgtgaccaccgccaccgccgccgttgccgccg	Protospacer
  * *********.************.**.*  .

180. spacer 32.3|7747001|34|NC_017030|CRT matches to KF279413 (Mycobacterium phage Bane2, complete genome) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
tacgtgaccaccgccaccgccgccgttgccgccg	Protospacer
  * *********.************.**.*  .

181. spacer 32.3|7747001|34|NC_017030|CRT matches to KT021004 (Thermobifida phage P1312, complete genome) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
ccgatgaccaccatcaccgccgccgacgccgccg	Protospacer
 *  ********.************ ***.*  .

182. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP054615 (Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
tccatgaccaccgacaccgccgccgggaccgcaa	Protospacer
 ** ********* ***********  .*.* .*

183. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accatgaccaccgacaccgccgccgccccgatgc	Protospacer
.** ********* ***********.* * . *

184. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP040819 (Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
gccgccgccaccatcaccgccgctgtcgctgtcg	Protospacer
*** . .*****.**********.*******  .

185. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.735

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accatgaccaccgacaccgccgccgccccgatgc	Protospacer
.** ********* ***********.* * . *

186. spacer 37.1|9545246|30|NC_017030|CRISPRCasFinder matches to NZ_CP045361 (Roseivivax sp. THAF40 plasmid pTHAF40_a, complete sequence) position: , mismatch: 9, identity: 0.7

atccgtcgcggaaccggcatccgtcgaagt	CRISPR spacer
tgtcgtggcggaaccggcatccgtgacgct	Protospacer
  .*** ***************** . . *

187. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 10, identity: 0.706

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccaaagaagccaacggcgacgacggcgccgaaaa	Protospacer
 * * ****** ************.**** . ..

188. spacer 25.1|6829436|34|NC_017030|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 10, identity: 0.706

aacaggttccgggacaccgccgccggtaccacgg	CRISPR spacer
gaggtcttccgcgacaccgctgccggtaccgacg	Protospacer
.* .  ***** ********.*********.  *

189. spacer 25.1|6829436|34|NC_017030|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 10, identity: 0.706

aacaggttccgggacaccgccgccggtaccacgg	CRISPR spacer
gaggtcttccgcgacaccgctgccggtaccgacg	Protospacer
.* .  ***** ********.*********.  *

190. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP017563 (Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence) position: , mismatch: 10, identity: 0.706

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
gccctgaccaccgtcactcccgccgcttcgatcg	Protospacer
*****************. ******.. * .  .

191. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.706

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accatgaccaccgacaccgccgccgcaccgatgc	Protospacer
.** ********* ***********.  * . *

192. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 10, identity: 0.706

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accatgaccaccgacaccgccgccggaccgatgc	Protospacer
.** ********* ***********   * . *

193. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 10, identity: 0.706

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accatgaccaccgacaccgccgccgcaccgatgc	Protospacer
.** ********* ***********.  * . *

194. spacer 32.3|7747001|34|NC_017030|CRT matches to NC_015409 (Verrucosispora maris AB-18-032 plasmid pVMKU, complete sequence) position: , mismatch: 10, identity: 0.706

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
gcccggaccaccgccaccgccgccctgaccaccg	Protospacer
**** ********.********** * .*..  .

195. spacer 32.3|7747001|34|NC_017030|CRT matches to KF954506 (Mycobacterium phage Nyxis, complete genome) position: , mismatch: 10, identity: 0.706

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
ccaatgacccccgtcaccgccgccgccgttaccg	Protospacer
 *  ***** ***************.**.*.  .

196. spacer 32.3|7747001|34|NC_017030|CRT matches to KX550441 (Mycobacterium phage LittleGuy, complete genome) position: , mismatch: 10, identity: 0.706

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
ccaatgacctccgtcaccgccgccgccgttaccg	Protospacer
 *  ***** ***************.**.*.  .

197. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 10, identity: 0.706

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accatgaccaccgacaccgccgccgctccgatgc	Protospacer
.** ********* ***********.. * . *

198. spacer 32.3|7747001|34|NC_017030|CRT matches to LN997843 (Streptomyces reticuli genome assembly TUE45, plasmid : II) position: , mismatch: 10, identity: 0.706

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accatgaccaccgtccccgccgccggccacctgc	Protospacer
.** *********** ********* *  .  *

199. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NC_007763 (Rhizobium etli CFN 42 plasmid p42b, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

200. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP021025 (Rhizobium sp. TAL182 plasmid pRetTAL182a, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

201. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP020907 (Rhizobium etli strain NXC12 plasmid pRetNXC12a, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

202. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP013600 (Rhizobium sp. N741 plasmid pRspN741e, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

203. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NC_021906 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1a, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

204. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP013504 (Rhizobium esperanzae strain N561 plasmid pRspN561d, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

205. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP013510 (Rhizobium sp. N1341 plasmid pRspN1341e, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

206. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP013521 (Rhizobium sp. N113 plasmid pRspN113d, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

207. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP013494 (Rhizobium sp. N6212 plasmid pRspN6212d, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

208. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP013512 (Rhizobium sp. N1314 plasmid pRspN1314a, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

209. spacer 9.2|2188102|34|NC_017030|CRISPRCasFinder matches to NZ_CP013594 (Rhizobium sp. N871 plasmid pRspN871d, complete sequence) position: , mismatch: 11, identity: 0.676

gccacgaagcccacggcgacgacgacgcccgcgg	CRISPR spacer
ccgtggaagccgacggcgtcgacgacgccgagca	Protospacer
 *   ****** ****** ********** .  .

210. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_LR536451 (Methylocella tundrae isolate MTUNDRAET4 annotated genome plasmid 2) position: , mismatch: 11, identity: 0.676

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
accctgaacgccgtcaccgccgccgccctccttg	Protospacer
.****** *.***************.* ..   .

211. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_CP008954 (Amycolatopsis japonica strain DSM 44213 plasmid pAmyja1, complete sequence) position: , mismatch: 11, identity: 0.676

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
acgtcactcaccgtcacagccgacgtcgctggat	Protospacer
.* ... .********* **** *********.

212. spacer 32.3|7747001|34|NC_017030|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 12, identity: 0.647

gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
cacctgaccgccatcaccgccgccgtgctcttcg	Protospacer
  *******.**.*************  ..   .

213. spacer 32.3|7747001|34|NC_017030|CRT matches to MK411746 (Arthrobacter phage Sonali, complete genome) position: , mismatch: 16, identity: 0.529

------gccctgaccaccgtcaccgccgccgtcgctggga	CRISPR spacer
ccgaacgcctccgtcaccgcctccgtcgctgccg------	Protospacer
      ***.. ..*****.* ***.***.*.**

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2248898 : 2273504

Wolbachia_phage(16.67%)

tail,transposase,plate

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014394723.1\|2248898_2250866_+\|tail	phage tail sheath subtilisin-like domain-containing protein	A0A1B2LRR3	Wolbachia_phage	2.3e-06	27.3
WP_014394724.1\|2250889_2251399_+\|tail	phage tail protein	NA	NA	NA	NA
WP_014394725.1\|2251398_2252199_+	hypothetical protein	NA	NA	NA	NA
WP_148282210.1\|2252794_2253265_+	hypothetical protein	NA	NA	NA	NA
WP_014394726.1\|2253266_2254301_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_014394727.1\|2254297_2255620_+	AAA family ATPase	K9MCS8	Sulfolobus_virus	4.8e-08	35.2
WP_014394728.1\|2255613_2255886_+	hypothetical protein	NA	NA	NA	NA
WP_014394729.1\|2255879_2256527_+	hypothetical protein	NA	NA	NA	NA
WP_014394730.1\|2256526_2256817_+	hypothetical protein	NA	NA	NA	NA
WP_014394731.1\|2256821_2257952_+	hypothetical protein	NA	NA	NA	NA
WP_014394732.1\|2257948_2258770_+\|tail	phage tail protein	A0A292GCA1	Xanthomonas_phage	4.7e-06	32.1
WP_014394733.1\|2258786_2259197_+	GPW/gp25 family protein	NA	NA	NA	NA
WP_014394734.1\|2259189_2260383_+	hypothetical protein	NA	NA	NA	NA
WP_148282211.1\|2260379_2263271_+\|plate	baseplate J/gp47 family protein	NA	NA	NA	NA
WP_014394736.1\|2263267_2264884_+	hypothetical protein	NA	NA	NA	NA
WP_014394737.1\|2264916_2266779_+	hypothetical protein	NA	NA	NA	NA
WP_014394738.1\|2266788_2267817_-	toprim domain-containing protein	A7KV10	Bacillus_phage	1.1e-12	24.4
WP_014394739.1\|2268334_2269333_-	hypothetical protein	NA	NA	NA	NA
WP_014394740.1\|2269562_2270465_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_014394741.1\|2270673_2271441_+	SDR family oxidoreductase	A0A0M4JSW6	Mollivirus	1.7e-10	27.2
WP_014394742.1\|2271443_2272091_-\|transposase	IS701 family transposase	NA	NA	NA	NA
WP_014394743.1\|2272136_2272355_-	hypothetical protein	NA	NA	NA	NA
WP_014394744.1\|2272656_2273076_-	hypothetical protein	NA	NA	NA	NA
WP_014394745.1\|2273276_2273504_-\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	4.8e-09	46.7

DBSCAN-SWA_2

3266297 : 3273532

Staphylococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014395451.1\|3266297_3267047_+	3-oxoacyl-[acyl-carrier-protein] reductase	Q06VL0	Trichoplusia_ni_ascovirus	2.3e-23	35.8
WP_014395452.1\|3267153_3267402_+	acyl carrier protein	M4QDG5	Prochlorococcus_phage	4.0e-09	55.7
WP_014395453.1\|3267487_3268744_+	beta-ketoacyl-ACP synthase II	NA	NA	NA	NA
WP_014395454.1\|3268847_3269294_+	ribose 5-phosphate isomerase B	NA	NA	NA	NA
WP_014395455.1\|3269354_3270611_+	serine hydroxymethyltransferase	A0A219Y950	Aeromonas_phage	5.4e-94	50.3
WP_014395456.1\|3270620_3271124_+	transcriptional repressor NrdR	NA	NA	NA	NA
WP_014395457.1\|3271134_3272298_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	7.8e-47	32.8
WP_014395458.1\|3272338_3273004_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	2.2e-25	35.9
WP_014395459.1\|3273031_3273532_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.6e-26	43.0

DBSCAN-SWA_3

3536553 : 3552062

Bacillus_phage(100.0%)

tail,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014395674.1\|3536553_3539328_-\|tail	phage tail protein	NA	NA	NA	NA
WP_014395675.1\|3539328_3541647_-\|plate	baseplate J/gp47 family protein	NA	NA	NA	NA
WP_014395676.1\|3541654_3542047_-	GPW/gp25 family protein	NA	NA	NA	NA
WP_014395677.1\|3542051_3543602_-	hypothetical protein	NA	NA	NA	NA
WP_167594425.1\|3543598_3544315_-	type IV secretion protein Rhs	NA	NA	NA	NA
WP_014395679.1\|3544314_3545400_-	phage late control D family protein	NA	NA	NA	NA
WP_014395680.1\|3545412_3545586_-	hypothetical protein	NA	NA	NA	NA
WP_014395681.1\|3545597_3546341_-	hypothetical protein	NA	NA	NA	NA
WP_014395682.1\|3546344_3546833_-\|tail	phage tail protein	NA	NA	NA	NA
WP_014395683.1\|3546836_3549635_-\|tail	phage tail sheath family protein	NA	NA	NA	NA
WP_014395684.1\|3549636_3550089_-\|tail	phage tail protein	NA	NA	NA	NA
WP_014395685.1\|3550109_3552062_-\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	4.2e-45	33.4

DBSCAN-SWA_4

3995658 : 4076432

Bacillus_phage(20.0%)

tail,protease,transposase,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014396075.1\|3995658_3997668_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_052313009.1\|3997676_3999998_-	PAS domain-containing sensor histidine kinase	NA	NA	NA	NA
WP_014396077.1\|4000218_4000593_-	DUF1622 domain-containing protein	NA	NA	NA	NA
WP_014396078.1\|4000865_4002824_+	hypothetical protein	NA	NA	NA	NA
WP_014396079.1\|4002840_4005162_+\|tail	phage tail sheath subtilisin-like domain-containing protein	J9PVC2	Bacillus_phage	4.8e-64	40.9
WP_014396080.1\|4005161_4005725_+\|tail	phage tail protein	NA	NA	NA	NA
WP_014396081.1\|4005750_4006242_+\|tail	phage tail protein	NA	NA	NA	NA
WP_014396082.1\|4006243_4007119_+	hypothetical protein	NA	NA	NA	NA
WP_014396083.1\|4007138_4007351_+	hypothetical protein	NA	NA	NA	NA
WP_014396084.1\|4007347_4008076_+	hypothetical protein	NA	NA	NA	NA
WP_014396085.1\|4008086_4008365_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_014396086.1\|4008364_4009552_+	hypothetical protein	NA	NA	NA	NA
WP_014396087.1\|4009551_4009926_+	GPW/gp25 family protein	NA	NA	NA	NA
WP_014396088.1\|4009922_4013690_+\|plate	baseplate J/gp47 family protein	NA	NA	NA	NA
WP_014396089.1\|4013686_4016200_+	hypothetical protein	NA	NA	NA	NA
WP_014396090.1\|4017014_4020656_+	hypothetical protein	NA	NA	NA	NA
WP_014396091.1\|4020652_4028266_+	right-handed parallel beta-helix repeat-containing protein	NA	NA	NA	NA
WP_014396092.1\|4028297_4028639_+	hypothetical protein	NA	NA	NA	NA
WP_014396093.1\|4028638_4028848_+	hypothetical protein	NA	NA	NA	NA
WP_014396094.1\|4028844_4030032_+	rhs element Vgr family protein	NA	NA	NA	NA
WP_043321408.1\|4030036_4030231_+	hypothetical protein	NA	NA	NA	NA
WP_014396095.1\|4030199_4031810_+	hypothetical protein	NA	NA	NA	NA
WP_014396096.1\|4031806_4033969_+	hypothetical protein	NA	NA	NA	NA
WP_014396097.1\|4035176_4035908_+	hypothetical protein	NA	NA	NA	NA
WP_014396098.1\|4035904_4036126_+	hypothetical protein	NA	NA	NA	NA
WP_014396099.1\|4036268_4037501_+	hypothetical protein	NA	NA	NA	NA
WP_014396100.1\|4037517_4039362_-	hypothetical protein	NA	NA	NA	NA
WP_052313011.1\|4039358_4042622_-	lantibiotic dehydratase	NA	NA	NA	NA
WP_014396102.1\|4042697_4042874_-	hypothetical protein	NA	NA	NA	NA
WP_167594338.1\|4043056_4044346_+	lanthionine synthetase C family protein	NA	NA	NA	NA
WP_167594339.1\|4044733_4045129_+	AgmX/PglI C-terminal domain-containing protein	NA	NA	NA	NA
WP_014396105.1\|4045135_4046815_-	AMP-binding protein	NA	NA	NA	NA
WP_167594340.1\|4046811_4048326_-	hypothetical protein	NA	NA	NA	NA
WP_148282558.1\|4048659_4049328_-	SUMF1/EgtB/PvdO family nonheme iron enzyme	NA	NA	NA	NA
WP_014396108.1\|4050176_4050941_-	hypothetical protein	NA	NA	NA	NA
WP_014396109.1\|4050958_4051486_-	hypothetical protein	NA	NA	NA	NA
WP_014396110.1\|4051498_4059625_-	hypothetical protein	NA	NA	NA	NA
WP_014396111.1\|4059656_4062005_-	AAA family ATPase	A0A0R6PCP6	Moraxella_phage	1.1e-28	33.6
WP_014396112.1\|4062151_4062652_+	flavin reductase family protein	NA	NA	NA	NA
WP_014396113.1\|4062698_4063283_+	superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	1.9e-41	44.0
WP_014396114.1\|4063351_4063558_-	hypothetical protein	NA	NA	NA	NA
WP_014396115.1\|4063603_4066330_-	serine/threonine protein kinase	S4W2F5	Pandoravirus	8.6e-20	33.2
WP_014396116.1\|4066360_4067323_-	SMP-30/gluconolactonase/LRE family protein	NA	NA	NA	NA
WP_052313014.1\|4067400_4068201_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_014396118.1\|4068403_4069492_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	1.7e-83	45.0
WP_014396119.1\|4069588_4070902_+	restriction endonuclease	NA	NA	NA	NA
WP_148282265.1\|4070865_4071561_+	hypothetical protein	NA	NA	NA	NA
WP_014396121.1\|4071983_4074218_-	hypothetical protein	NA	NA	NA	NA
WP_014396122.1\|4075151_4076432_+\|transposase	IS1182-like element ISCoco1 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

7607913 : 7618696

Pandoravirus(14.29%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014398820.1\|7607913_7609794_+	protein kinase	S4W2F5	Pandoravirus	1.3e-11	30.4
WP_014398821.1\|7609814_7610357_-	hypothetical protein	NA	NA	NA	NA
WP_014398822.1\|7610393_7610879_-	SsrA-binding protein SmpB	W5RAM5	Staphylococcus_phage	4.3e-31	46.0
WP_014398823.1\|7610896_7611751_-	pantoate--beta-alanine ligase	NA	NA	NA	NA
WP_014398824.1\|7611753_7612662_-	3-methyl-2-oxobutanoate hydroxymethyltransferase	A0A0P0BXC9	Ostreococcus_lucimarinus_virus	9.1e-51	40.9
WP_014398825.1\|7612831_7613473_-	deoxynucleoside kinase	A0A291I9G8	Lactobacillus_phage	1.9e-18	31.3
WP_043321988.1\|7613654_7613942_+	hypothetical protein	NA	NA	NA	NA
WP_014398827.1\|7613948_7614827_-	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	E4ZFQ0	Streptococcus_phage	4.3e-13	31.5
WP_014398828.1\|7614837_7615836_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	1.9e-73	45.7
WP_014398829.1\|7615888_7618696_-	response regulator	Q56AR1	Bacillus_thuringiensis_phage	5.0e-07	30.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_017030

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CRISPR-Cas detection and classification

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