CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_018014	Terriglobus roseus DSM 18391, complete sequence	11 crisprs	csa3,Cas9_archaeal,cas3,WYL,DinG	1	1	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_018014_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_1

120943-121019

Orphan

Consensus_repeat	Method
TCTTCACTTTGATGACCTCAGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018014_1

>merge|NC_018014|1|120943-121019|CRISPRCasFinder
TCTTCACTTTGATGACCTCAGGACGAAGCGGAACATGCGTCCCTGCCGTTTCGCTCTTCACTTTGATGACTTCAGGA

>NC_018014|1|1|120943-121019|CRISPRCasFinder
TCTTCACTTTGATGACCTCAGGA	CGAAGCGGAACATGCGTCCCTGCCGTTTCGC
TCTTCACTTTGATGACTTCAGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_014784024.1\|122314_123082_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NC_018014.1\|WP_174277922.1\|126746_127565_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014784031.1\|130504_131359_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NC_018014.1\|WP_157178495.1\|109491_110226_+\|DUF1080-domain-containing-protein	unknown	unknown	gnl\|CDD\|368908
NC_018014.1\|WP_014784015.1\|112177_113422_-\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223104
NC_018014.1\|WP_014784023.1\|121362_122157_-\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NC_018014.1\|WP_014784016.1\|113626_116005_+\|LssY-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379450
NC_018014.1\|WP_157178207.1\|118206_118986_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014784019.1\|117669_118020_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_018014.1\|WP_014784014.1\|111278_112112_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|180446
NC_018014.1\|WP_014784017.1\|116059_116896_-\|TIGR03435-family-protein	unknown	unknown	gnl\|CDD\|132476
NC_018014.1\|WP_157178496.1\|127707_128619_+\|DUF1080-domain-containing-protein	unknown	unknown	gnl\|CDD\|368908
NC_018014.1\|WP_014784032.1\|131620_133828_+\|bifunctional-rhamnulose-1-phosphate-aldolase/short-chain-dehydrogenase	unknown	unknown	gnl\|CDD\|236241
NC_018014.1\|WP_014784021.1\|119111_119840_-\|LUD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224473
NC_018014.1\|WP_014784027.1\|126239_126620_+\|response-regulator	unknown	unknown	gnl\|CDD\|381085
NC_018014.1\|WP_014784026.1\|124190_125813_+\|TIGR03435-family-protein	unknown	unknown	gnl\|CDD\|372177
NC_018014.1\|WP_014784018.1\|116899_117673_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014784013.1\|110232_111132_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377694
NC_018014.1\|WP_014784025.1\|123188_124040_+\|fatty-acid-desaturase	unknown	unknown	gnl\|CDD\|177866
NC_018014.1\|WP_014784030.1\|128678_130193_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_014784024.1\|122314_123082_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.65176e-66
NC_018014.1\|WP_014784031.1\|130504_131359_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	2.14206e-102
NC_018014.1\|WP_157178495.1\|109491_110226_+\|DUF1080-domain-containing-protein	gnl\|CDD\|368908	pfam06439, DUF1080, Domain of Unknown Function (DUF1080). This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.	6.21479e-24
NC_018014.1\|WP_014784015.1\|112177_113422_-\|cation:proton-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	1.22869e-45
NC_018014.1\|WP_014784023.1\|121362_122157_-\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	1.10111e-47
NC_018014.1\|WP_014784016.1\|113626_116005_+\|LssY-C-terminal-domain-containing-protein	gnl\|CDD\|379450	pfam14067, LssY_C, LssY C-terminus. This domain is found at the C-terminus of Legionella LssY proteins, which may be a part of the type I secretion system. This domain is functionally uncharacterized. This domain is found in bacteria, and is typically between 182 and 195 amino acids in length. It is often found in association with pfam09335 and PF01569. There are two completely conserved residues (P and W) that may be functionally important.	1.66271e-58
NC_018014.1\|WP_014784032.1\|131620_133828_+\|bifunctional-rhamnulose-1-phosphate-aldolase/short-chain-dehydrogenase	gnl\|CDD\|236241	PRK08324, PRK08324, bifunctional aldolase/short-chain dehydrogenase.	0
NC_018014.1\|WP_014784019.1\|117669_118020_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.69553e-06
NC_018014.1\|WP_014784014.1\|111278_112112_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|180446	PRK06180, PRK06180, short chain dehydrogenase; Provisional.	3.31025e-103
NC_018014.1\|WP_014784017.1\|116059_116896_-\|TIGR03435-family-protein	gnl\|CDD\|132476	TIGR03435, Soli_TIGR03435, soil-associated protein, TIGR03435 family. Bacterial reference strains encoding members of this protein family are all isolated from soil. These include 39 members from Solibacter usitatus Ellin6076, 27 from Acidobacterium sp. MP5ACTX8 (both Acidobacteria), and four from Pedosphaera parvula Ellin514 (Verrucomicrobia). The family is well-diversified, with few pairs showing greater than 50 % pairwise identity. A few members are fused to Peptidase_M56 domains (see pfam05569), to Sigma70_r2 domains (see pfam04542), or have a duplication of this domain.	5.04688e-75
NC_018014.1\|WP_014784021.1\|119111_119840_-\|LUD-domain-containing-protein	gnl\|CDD\|224473	COG1556, COG1556, Uncharacterized conserved protein [Function unknown].	3.52049e-29
NC_018014.1\|WP_014784027.1\|126239_126620_+\|response-regulator	gnl\|CDD\|381085	cd00156, REC, phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs). Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.	1.24623e-14
NC_018014.1\|WP_157178496.1\|127707_128619_+\|DUF1080-domain-containing-protein	gnl\|CDD\|368908	pfam06439, DUF1080, Domain of Unknown Function (DUF1080). This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.	3.13634e-40
NC_018014.1\|WP_014784026.1\|124190_125813_+\|TIGR03435-family-protein	gnl\|CDD\|372177	pfam12543, DUF3738, Protein of unknown function (DUF3738). This family of proteins is found in bacteria. Proteins in this family are typically between 251 and 457 amino acids in length.	9.828e-63
NC_018014.1\|WP_014784013.1\|110232_111132_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|377694	pfam06719, AraC_N, AraC-type transcriptional regulator N-terminus. This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.	8.07191e-59
NC_018014.1\|WP_014784025.1\|123188_124040_+\|fatty-acid-desaturase	gnl\|CDD\|177866	PLN02220, PLN02220, delta-9 acyl-lipid desaturase.	2.9738e-73
NC_018014.1\|WP_014784030.1\|128678_130193_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.07406e-114

>NC_018014.1|WP_014784021.1|119111_119840_-|LUD-domain-containing-protein
MSESRLHDDARFHEDARWHEEDRQREDARFTVLDTIRRQLAADPDIKDELIESPEAAYARIQRTYQRSAQLDREEILELFYDRLRDYDSELIFTDEAGIADAVLQAMSEANETLLLVPTGVPDAWLPSSGISILRDEQLTTSALDQPRVVLTGCTACVAMSGTIILEHGDEQGRRAATLLPDHHLCVLWRDQVVETLSEAMQRITKRTAPITTIAGPSATSDIEMTRIRGVHGPRRLTAIIL
>NC_018014.1|WP_157178207.1|118206_118986_-|hypothetical-protein
MKLLLPILLLPALTPACAQRPSAAQRESVAERPAVSKNPTYLFRSVSVSEEWDHAADDTLTTSVEYTEPFHDAATAVGVSVPIAKSVIGPAGESFGLGDMSVRGQWIPYETLHDGVLLTGTFTMPTGGKSGGSGKWRCTPSGAYARFWGPRFLLAQFVQQEFSFAGAADRDRINRTDLDLYGVYSSASQRWWINGDVNLRVDEANRNSLSSTTTVSYGRGLRRMMGGSLNGSVQTGFGMGVGRPYSEVVLVSVSLVGFH
>NC_018014.1|WP_014784019.1|117669_118020_-|PadR-family-transcriptional-regulator
MSERLPLNDSDLVTLLAILRLGDEAYGVSLCKEIGSITGTGAALASVYKALDRLEQSGLVVSRMGEPSPERGGRAKRLVRVTAKGLRAIDETRAALNDLWRDVPVYGSIAQKEKSR
>NC_018014.1|WP_014784018.1|116899_117673_-|hypothetical-protein
MRQDPVLGVALWLLTVSSSGRDAEAFAGDLLELFHAGCSRWWCLRQALLRSGSVTEQRLRASLVPLCYCAVFVLLHPLWQQLYTPSVAGLLTKYRGAIQWPGSAVLEMIAGLLPAFLFLYVGVFVYSLLRHRSLQSHPVATLLSLNVGACLLFVAMLVRLHVLHNDLRLLSRADFYYPLVHGRFSVLLFLSLFGAVLILPRTDQPRRRKPSHVAMRSMVQRIARRFGSMAPPDVPRAIRRPHETATKSLLLFTMSER
>NC_018014.1|WP_014784017.1|116059_116896_-|TIGR03435-family-protein
MRLTYSLLFSGLTMFAYPLSMCAQYTTPRLMALDGKPLEFDVVSVKPSNPGATGMRIGSPLMSGGFEITNMPPENIVQWAFGIFLSDQIAGLPNWAKQERFDVTAKVDDAELETYRNVTDPIRRAPMLQKILIDRFAMKFHYETKELPVYALVVSKGGSRMTEIEPAIGPNGMKDGGTREVRRGQIRSMGQPMKPLINQLTIELKRAVVDRTELTGFYNFTLRWTPDEGATPTNSALEENAAPSIFTALQEQLGLKLERTKAPVQVLVIDRLERPSAN
>NC_018014.1|WP_014784016.1|113626_116005_+|LssY-C-terminal-domain-containing-protein
MQLIFTLQKAVVLSALALGSAATAAAQLVIPAQTPIEIRLTERVSTRLSKKGSVVHAIIAAPVLAGDGIVLPMGSKVEGRVVHVNSVRLGFTHETSSIGLDMERIILPDGTIVPLAARVAQIENSREVINKQGRIAGVRSTSTLSHKTSGAVGTLAFSNPIALIFTTASSASLLRFSDPEISLPANTELILLTTQPISIAHGTESAAPALAQDAESERALTGLIRRQPYRTVTDPKHTPSDLTNLMFIGDQSAILRAFQAAGWLQVDTLDATSAYRTVRAVSEVQAYRTAPMSTLLLEGQKPTLGLAKTLDTFSKRHHLRVFATQEEWQGQRVWLSSSTQDIGIGFSASQKNFIHQIDHNIDHERAKVVNDLMLTGCVTGLNLVARSWLPKDIKNGTGEEIVTDNRMAVVRLNDCEAPINVPAVDQTAAMPVHQNKLVQVTRQTTLTLRNTILRDNLAVSAYGGVRMALGLKHPKPPEQPLEVSSEINAHRYAIGKAEATADDKPELQKRDFVETAKAGTTADLALNPPKRLPPYSVEIGVHGGFAGYAGGNGGAIGYLLLPEDAVANPPYLLVLGNEHNNGFNLGGSVTLNSHQHLSHEFSFDYNRTGFMLGFADLNLLPGPDTDPTTQSDFAFEEATLSTTEVAYNLQYLPLRRESRWRPYVSAGPSLRLMHLTEAPITRASPWFKLGLSTVGAITAAYRFASIPPLEGGGIFQVGLQYGGGVKYRASRRILLRADYKETLSAQPDFWSKSKDDIFDAADLPGYGLTVIGPIMDGVMRQQRATMGISFVF
>NC_018014.1|WP_014784015.1|112177_113422_-|cation:proton-antiporter
MLALIAIVVSLAAIFGLVSSRWLKLPTVVGTMLLTVLLSTVLAFTSHSFPAVHAWALHSVLRIDYERFILHGLLSLLLFAGAFLLDLEHLSREKFAVGMLAGLGTLLSTGLVGTALFFAAPLLGQHPSFLQTLLFGALISPTDPIAVLEMLRRVAAPRYLQAQLAGESLFNDGVGAVLFVTILGIAQSGRMPSAWEVSGRFLLDAGGGLALGVLLAMPISRMMRAVNAYHIEILLTLALALGGYAIADNLHLSAPLEAVAAGLALRWQNSRHPADISHTAIEGFWTAIEEVQNAVLFVLMGCEFLAVPFTVGSVNVGLVSIVLVNAVRFVTTGMVLGLVRLVQPAHKTSLLMIAWGGLRGGLSIALALSVPEELGRNWILVATYVVVVFSIVVKGGSMDLFLQRFRGHITDQAA
>NC_018014.1|WP_014784014.1|111278_112112_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSKVWMITGASRGLGLEIAKAALAAGDQVIAGARDAAKITSALGTQEHLLAVALDVTVPAQSTAAVAAGIERFGHIDVLVNNAGYGHFGPFEQASADDIEAQYSVNVFGAMHVTRAVLPGMRQQKSGRIFNISSVAGLKGGPMASLYCSSKFALEGWSESLAGELQPLGIQVTAVEPGFFRTDFLEPTSVRYTDAALPEYAPGLEQMQAWLNGKSLQQEGDPAKLAKVLVDVASKPEQPLHLLMGSDAIAWMEDRLQRDAKNVEEWRTVSASTDFPM
>NC_018014.1|WP_014784013.1|110232_111132_-|AraC-family-transcriptional-regulator
MTSLQELQRRIVDHATAPITVTAVPGLSLYHADSDAPLSAQLIYTPMVCIMAQGEKKVLLGDSVFRYTPESYLVSSVDLPVTGRVCNAAPGRPYLALSLAIDTRLLSELLMTLPPAATETEPRCGLAIGKVDAALLDCFVRLTRLLDEPGAIAMVAPLIAREILYRLLQGEQAQMLRQIATQESRTYQVARVVQWIREHYAEPFSAQVLAEVANMSPASLHRHFRAITAMSPLQYQKQVRLQEARRLLVTQGEDAATAGFHVGYASPSQFSREYTRTFGKPPRQDAAHLQSLAGAVAIP
>NC_018014.1|WP_157178495.1|109491_110226_+|DUF1080-domain-containing-protein
MPKFHDPLPYDIDDHAGYTQLFDGKTMKGWDGDPSIWRIEDGVMIGETKEEERKGNSYIVYTADKAKDFDLKLQMKIEKGGGGGIQYRSHTGEAWTRPQPAGAGPNGTPPKWLLTGPQADFWFPVRQSASNYTGQWYSENTMQGILAYRGQVTQALPGKGNRLVANIGDKLALGGYVKTNEWNDYEIIARGGVMMHIMNGQLMATFIDDDPNDANNQMGLIGFEIESQPCKISVKDIWWRKFDK
>NC_018014.1|WP_014784023.1|121362_122157_-|(Fe-S)-binding-protein
MRIHLFIACYNDTLFPRTGMAVVNLLERLGHDVVFPMAQTCCGQMHYNTGYHQEAMPLVKRLIDEFRDAETIVVPSASCVAMMRDHYELMAHNANDLRMMEDVKEFLPRVFEFSELITDKLGLTDVGAYFPHKVTYHPSCHSLRLLHVGDRPIRLLQGVEGLDYTPMEGADQCCGFGGTFAVKNAEVSSAMLADKIGCVRKTSAEFVAALDNSCLMQIDGGLHRESNGKGAEGRIRPVHLAEILNSTREKPLTAESLAWEGATA
>NC_018014.1|WP_014784024.1|122314_123082_+|SDR-family-oxidoreductase
MSQPKQFATYPSLRGRVVVVSGGASGIGEAIVEAFAEQGAQVAFLDILDDAANALVARLSGHSVKFYRCDLLNISAIQQTCMQIAEDLGTVDVLVNNAGNDTRHDLETVTEEMWDGALNLNLRHQFFLAQALLPGMRAQKRGSIINLSSIAWMIPSTDLPVYVTSKSAIIGMTRAMAHRVGMDGVRVNAVLPGSIATERQRRLWLTPEYTAQILARQALKFELQPADVARMILFLAADDSAGITNQSFVVDGGWV
>NC_018014.1|WP_014784025.1|123188_124040_+|fatty-acid-desaturase
MPASELTARDRTFSQPIAWTTSIVLVAFHLGAIAALFFFTWKAFFVAMVLWWVAGGLGIGVGYHRLLTHRGYKTPKWVEYLLTIFATLTLEGGPIFWVATHRKHHQNTDKEGDPHSPNEGGFWSHVGWLVTGKTMHNDAAELLPYVPDLRKDKFHVWISRWHWVPLTTLGLVLLAVGGLPFLLWGIFFRTVLGLHSTWLVNSATHMWGSRRFATGDSSRNSFWVAMLTFGEGWHNNHHAHPQSSRHGLAWYEIDFNWYGICALRALGLAWDVKARSLSEGNAH
>NC_018014.1|WP_014784026.1|124190_125813_+|TIGR03435-family-protein
MKRLLPKLSILCVLSSAAWGQQPADIKPAAAKAAFTIADVHASPRVSFPNSDSGQLRGERYSLHQATLVDMIALAYGVKPEMVQGGPSWLELPRFDVTAKADPKTSDAELKRMLQALLADRFKLVVHKGEAPMPAFLLTAPSGKPKMQQSKDGETKSCKADTTPPAPGEVPLFVLACTHMSSEEIATFLSQAAGNFLTEPVLDQTGLEGAWDFTLSFTGPRERAKAGAAAVSIFDAVEKDLGLKLELKTAPRLVWIVDSVTEKPTPNSPAVVKELPTLAPTEFEVSTIKPAKPDAQPGGRVANGQMNITATTLKNLFSFVWDFNSNDPQLLANAPAWLDKDKFDFFAKAVMPEQIPGRPPVQFYEVEFRQMLQTLLMDRFQMKVHREDRPIFAYKMVADHPKLTKADPTKRTHCKQGPGPDGKDPRVVNPMLTALLTCQNITMKQLGEQLTQFATGYIYTPVLDETGLTGGYDLTLAWSSAALTILRPPPPPGQPEEALSADAVTLYDAMQKQLGIRMVKEKRPVSVLVIDHIEETPTPN
>NC_018014.1|WP_014784027.1|126239_126620_+|response-regulator
MQFTGVRAFVVDDDVIVASTLAAILRLHGFAVRYYIDPTEALADALVDPPNLLVSDVIMPILSGIDLALQIKALCPDCKILLFSGQADTVDFVQDAQRVDANLHIMPKPMKPSMLLEVISQKLMQN
>NC_018014.1|WP_174277922.1|126746_127565_+|hypothetical-protein
MATPPDFFSPVVPDALGALRNMQPTVATGAPARRAPSFQIIERKPPRPAAILLAFVMAASVASAVAYGLNHSKAARLADGRSSAARDPNEKPGDTPHEDDKDDDPSQVDTIVLGDAADAPVPARRKDHISPVHATILVHLPRFGPQAGLIPDTPSGRLLYSWLAAFNQGSDTALEQAVPNVAPVYSAAAQMVLRAQTGGFNLLSAKEVQPGVLVFRLRDQTPAGNEVLGTLQMRAKSDPPAIASLSLRAVPSTKPNAVAATAQSTPTNPQRN
>NC_018014.1|WP_157178496.1|127707_128619_+|DUF1080-domain-containing-protein
MAAQDSKAFLGRWDLTVTPSTGKAYPQWIELKENGGKMEGRVQPRGGGWHPIAGAHLESGKLIVDLGETGAAASTTWELTTPSAGKLTGIEKRGDAADGLTIAGAKAPSLDRPMPKAWTKPRPLFDGKDLKGWEPIGNVENNKWIARNGELVNDNPETPGRRGPGAANIKTTEKFQDFKLHIEVNCPEGGNSGIYLRGRYELQVGTEGGKLPSHEMGAIYSHYPPPAGSELGLGKWTSFDVTFVGRHVTVLRDGKMYHDNVEIPGPTGGALDSNESEPGPFFLQGDHHGVIAYRNITISVPKK
>NC_018014.1|WP_014784030.1|128678_130193_-|SulP-family-inorganic-anion-transporter
MNIQTLRSEVLAGLTAALSLVPEVVGFALVAHVNPLNGLYAAFILCLIAAIFGGRPGMISGAAGSMAVVSAALVVQHGIDYLFATIVLTGILQLLFAVFRLGKLIRMVPHSVMLGFVNGLAIIIASAQFQHLRQRMPDGTEHWLPSSALLTMLGLIAVTVAVTVLLPKLTKAFPSALAGILAATACALAFGIHTRTVGDLSSIRGTLPHFHLPAVPYTWETLRITLPYALVLATIGLVETLLTLNLIDELTDTTGEPNRESMAQGIGNIVGAFFTGIGGCAMIGQSIINLNAGGKRRLSGVAAGGFLLSFILVGSRLIERIPLAALVGVMFVVAAETFNWQSLRNAFSFPGRIPRHDTLVMLLVTLVTVLTNLAVAVVAGIVIAALVFAWDHAQQLEVDVLEANGRKTYRLHGSLFFASAAQFTAFFSPKTDPVETYLEFDHARIMDSSALEVIESIAKRYREAGKALHIHGLSESCDRLLRRKDGAILLVSREPAASSTQVLS
>NC_018014.1|WP_014784031.1|130504_131359_-|fumarylacetoacetate-hydrolase-family-protein
MKLFRYGQRGSERPGVLDSAGKLRDLSNVIADVAGAALAPESLARIAALDLSTLPEVPAGERIGACVGGVGKVICIGLNYADHAAESGAAVPVEPIVFMKATSALCGPDDGIIIPKDSQKTDWEVELAVVIGLEARYIDEANAMDYVAGYCVANDLSERAFQLEGTGQWVKGKSADNFGPMGPWLVTKDEVADPQNLHLWLEVDGHRFQDGSTETMVFGVAYLVAYLSKFMTLQPGDIISTGTPPGVGLGQKPPIYLKPGQVVRLGIDGLGEQTQKVVTYESTL
>NC_018014.1|WP_014784032.1|131620_133828_+|bifunctional-rhamnulose-1-phosphate-aldolase/short-chain-dehydrogenase
MATAKLKFLEDRWDDAVASKLDAPELLRYRSNLLGSDLRLTNFGGGNTSSKLDEVDPLTGETVKVLWVKGSGGDLGSIKRSGFATLYLDKVLSLTKRYRGVENEDEMVAMYPLCTFNNNPTAASIDTPLHGYLPFPHVDHLHPDWGIALAASANGLEKMEQFNKEFGHKIVWVPWQRPGFELGMMLKRAVEANPGCDGIVLGGHGLFTWGETQRESYLNTVTIIDQIGQFIEAHNLKKALTAFGGVKHTNHAERETLAAQLMPVIRGGVSQKQRLIGTFSDHDDVLEFVNSQYAKTLAHLGTSCPDHFIRTKIRPMYVEWDPKTDVSELKAKITSALATYREEYAAYYSNHALPESPKMRDPNPTVVLVPGVGMFSFGKNKAESRITGEFYLNAIHVMNGAGQLGDGTCPAELPQAGPAAPTSAFATEENYVALPPSEAFRIEYWALEEAKIQRQPPEKELSRRIVMVVGGASGIGRETVLLAASRGAHIVVADLTQDGADKVVAEAQAIGGKECAIGTTIDIRNREKIKAALDKCVAAFGGLDILINTAAIFPTSPTGAISDAQWGTTLEINVTANWLLSDEANKVFAAQALPGSSIVLTSSANAVVPKKGTEVYDISKAALSHLVRELAITFSPDVRVNGISPATVVKGSTMFPRDRVKASLSKYNLPFEESESDDELRNKLAHFYAKRTLTHIPIDPKDNAEAILFIGGPKAPVTSGHLIPVDGGLPEAFLR

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Crispr_ID: NC_018014_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_2

242626-242715

Orphan

Consensus_repeat	Method
GTTGGCGCGGGCCTTCAGCCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018014_2

>merge|NC_018014|2|242626-242715|CRISPRCasFinder
GTTGGCGCGGGCCTTCAGCCCGCAGAGTCACAGGTAATCGCTAACCCAGGGCGTTGCCCTGGGCTAGGATGGCGCGGGCCTTCAGCCCGC

>NC_018014|2|2|242626-242715|CRISPRCasFinder
GTTGGCGCGGGCCTTCAGCCCGC	AGAGTCACAGGTAATCGCTAACCCAGGGCGTTGCCCTGGGCTAG
GATGGCGCGGGCCTTCAGCCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_041592823.1\|254710_255445_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349966
NC_018014.1\|WP_014784121.1\|235808_236720_-\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NC_018014.1\|WP_014784128.1\|245832_246894_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293817
NC_018014.1\|WP_014784130.1\|248053_248944_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NC_018014.1\|WP_014784124.1\|239091_239754_-\|Bax-inhibitor-1-family-protein	unknown	unknown	gnl\|CDD\|376437
NC_018014.1\|WP_014784120.1\|234978_235431_-\|response-regulator	unknown	unknown	gnl\|CDD\|381085
NC_018014.1\|WP_014784131.1\|249028_250381_+\|DNA-directed-DNA-polymerase	unknown	unknown	gnl\|CDD\|176453
NC_018014.1\|WP_014784118.1\|232303_232507_-\|4-oxalocrotonate-tautomerase-family-protein	unknown	unknown	gnl\|CDD\|224853
NC_018014.1\|WP_014784133.1\|251451_252081_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014784123.1\|237952_238681_+\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|367555
NC_018014.1\|WP_014784127.1\|242970_245793_-\|VacB/RNase-II-family-3'-5'-exoribonuclease	unknown	unknown	gnl\|CDD\|273947
NC_018014.1\|WP_157178213.1\|250783_251332_-\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NC_018014.1\|WP_014784117.1\|231375_232299_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226631
NC_018014.1\|WP_014784136.1\|255596_256280_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293807
NC_018014.1\|WP_014784116.1\|230098_231334_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224582
NC_018014.1\|WP_014784125.1\|240142_242545_-\|ATP-dependent-helicase-HrpB	unknown	unknown	gnl\|CDD\|273901
NC_018014.1\|WP_014784122.1\|236915_237572_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239314
NC_018014.1\|WP_014784129.1\|247085_247883_-\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|379309
NC_018014.1\|WP_014784134.1\|252159_254664_-\|DPP-IV-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|366374
NC_018014.1\|WP_014784119.1\|232588_234913_+\|ATP-dependent-DNA-helicase-RecG	unknown	unknown	gnl\|CDD\|236794

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_041592823.1\|254710_255445_-\|RNA-methyltransferase	gnl\|CDD\|349966	cd18093, SpoU-like_TrmJ, SAM-dependent tRNA methylase related to TrmJ. tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	2.76882e-53
NC_018014.1\|WP_014784121.1\|235808_236720_-\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	7.49285e-75
NC_018014.1\|WP_014784128.1\|245832_246894_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293817	cd07731, ComA-like_MBL-fold, Competence protein ComA, ComEC and related proteins; MBL-fold metallo hydrolase domain. This subgroup includes proteins required for natural transformation competence including Neisseria gonorrhoeae ComA, Pseudomonas stutzeri ComA, Bacillus subtilis ComEC (also known as ComE operon protein 3) and Haemophilus influenza ORF2 encoded by the rec-2 gene, as well as Escherichia coli YcaI which does not mediate spontaneous plasmid transformation on nutrient-containing agar plates. It also includes the phosphorylcholine esterase (Pce) domain of choline-binding protein e from streptococcus pneumonia. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. .	1.23727e-24
NC_018014.1\|WP_014784130.1\|248053_248944_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	9.54304e-51
NC_018014.1\|WP_014784124.1\|239091_239754_-\|Bax-inhibitor-1-family-protein	gnl\|CDD\|376437	pfam01027, Bax1-I, Inhibitor of apoptosis-promoting Bax1. Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.	1.90938e-20
NC_018014.1\|WP_014784120.1\|234978_235431_-\|response-regulator	gnl\|CDD\|381085	cd00156, REC, phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs). Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.	2.34772e-22
NC_018014.1\|WP_014784131.1\|249028_250381_+\|DNA-directed-DNA-polymerase	gnl\|CDD\|176453	cd00424, PolY, Y-family of DNA polymerases. Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.	5.82841e-80
NC_018014.1\|WP_014784118.1\|232303_232507_-\|4-oxalocrotonate-tautomerase-family-protein	gnl\|CDD\|224853	COG1942, COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only].	5.5879e-16
NC_018014.1\|WP_014784123.1\|237952_238681_+\|energy-transducer-TonB	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	1.86072e-17
NC_018014.1\|WP_014784127.1\|242970_245793_-\|VacB/RNase-II-family-3'-5'-exoribonuclease	gnl\|CDD\|273947	TIGR02063, Ribonuclease_R, ribonuclease R. This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA].	0
NC_018014.1\|WP_157178213.1\|250783_251332_-\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	3.2216e-38
NC_018014.1\|WP_014784117.1\|231375_232299_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226631	COG4152, COG4152, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	1.0688e-108
NC_018014.1\|WP_014784136.1\|255596_256280_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	2.50728e-67
NC_018014.1\|WP_014784116.1\|230098_231334_-\|ABC-transporter-permease	gnl\|CDD\|224582	COG1668, NatB, ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism].	1.28213e-36
NC_018014.1\|WP_014784125.1\|240142_242545_-\|ATP-dependent-helicase-HrpB	gnl\|CDD\|273901	TIGR01970, ATP-dependent_RNA_helicase_HrpB, ATP-dependent helicase HrpB. This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity].	3.48069e-166
NC_018014.1\|WP_014784122.1\|236915_237572_+\|peroxiredoxin	gnl\|CDD\|239314	cd03016, PRX_1cys, Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by reducing and detoxifying hydrogen peroxide, peroxynitrite, and organic hydroperoxides. As with all other PRXs, a cysteine sulfenic acid intermediate is formed upon reaction of 1-cys PRX with its substrates. Having no resolving cysteine, the oxidized enzyme is resolved by an external small-molecule or protein reductant such as thioredoxin or glutaredoxin. Similar to typical 2-cys PRX, 1-cys PRX forms a functional dimeric unit with a B-type interface, as well as a decameric structure which is stabilized in the reduced form of the enzyme. Other oligomeric forms, tetramers and hexamers, have also been reported. Mammalian 1-cys PRX is localized cellularly in the cytosol and is expressed at high levels in brain, eye, testes and lung. The seed-specific plant 1-cys PRXs protect tissues from reactive oxygen species during desiccation and are also called rehydrins.	7.58266e-114
NC_018014.1\|WP_014784129.1\|247085_247883_-\|2OG-Fe(II)-oxygenase	gnl\|CDD\|379309	pfam13640, 2OG-FeII_Oxy_3, 2OG-Fe(II) oxygenase superfamily. This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.	1.3792e-14
NC_018014.1\|WP_014784134.1\|252159_254664_-\|DPP-IV-N-terminal-domain-containing-protein	gnl\|CDD\|366374	pfam00930, DPPIV_N, Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.	2.46653e-63
NC_018014.1\|WP_014784119.1\|232588_234913_+\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0

>NC_018014.1|WP_014784125.1|240142_242545_-|ATP-dependent-helicase-HrpB
MAATPRKPALPIDDLLPEITAALRANNNLVLQAEPGAGKTTRVPPALLEVVPGEVIVLEPRRLPARMAARRVAWEMNEQAGETVGFQVRFEEAIGPRTRLRFVTEGILIRRLISDPLLPSVDAIVLDEFHERHIDSDLALALLRRLQQTTRPDLKIIVMSATLDAAPVAEFLGNCEMLYAAGRVFPLTVEHTPYSVEPLHVQVRQAVERLHRENHTGHTLVFLPGAAEIRRTMRECDGIARAAGLLMLPLYGDLSPAEQDRAVGPSTQPKLILSTNVAESSVTVEGVTAVIDSGIARVAAHSPWTGLPTLEIRRISKASATQRGGRAGRTAPGRVLRLYAEADFAQRAEHDRPEILRTDLSQLALTLRALDLRMGDVVWLDAPETIAVDHAEALLDRLGAAGAMARRLARFPLPPRLARMLVAAEDAGVAQEGATAAALLSVGASVERNDLLEAMDAQFAVPDHRVRQTESQLRRLVRKGQTKHTGDSDEPLLRAMLQGFPDRVARRRTGKEILLGTGITAEMTGAAPLYEFMVVLDAEDRSDKPLPLVRMAARFEPDWLIDLFPDRVREESTLVWNRSAQRVEATTSLRYEGLLLQEWRDAKPDAEAAAAMLAHEAVVAGIARFVDETAMENLQARAAFAGLQAPDVEAELRQLCLGLTRFSMDELRKAAVGLLPSMEARLDAQHLRDLAPGTLKLKAGRALKVHYETGKPPWIESRMQDFFGMSDGPRIGPDQTPVVMHLLGPNNRAVQTTSDLAGFWQRLYPEVRRGLMRRYPKQKWPENPLRPNAQPKEPTTPPRT
>NC_018014.1|WP_014784124.1|239091_239754_-|Bax-inhibitor-1-family-protein
MYVNRTNGFPTVIDVPREGTAPLLAKVLGITALGFFVTAIGVATAPPWSMLPGFIAVLALVFGINAVRRTNAGLAMALFMALAFFMGWEIAPIIHMYVRMIGPGIVFQAAVTTGLGMTAMGCVAYLFSIDYRKLSGIALAGLLLLILAGVASMFFHFMSPNTYSWIALAIFTALTVADFARIRAGGDGMGAVSLALGIYLDAINIFMILLQLFSGRSRRD
>NC_018014.1|WP_014784123.1|237952_238681_+|energy-transducer-TonB
MFQDSLLVESSGRLKSKSSCYVWVTATFNAAVVAVAVLLPLLYPDALPRMAMTAMLSAPPAPPAAPAPPPVVSARVARVTASVDPFVPPARVPRHLDMTRDDPPPSVSGVVRMTGGGSGDGPGVIGSLGLGPAPPVVSVAVARPVVGPARVSSGVMAGQIVTKTTPVYPAIAKAAHVSGAVVLHAVISKTGAIESLSVVSGHEMLRASAVAAVQGWRYRPYLLNGDPTEVETTITVNFSFGG
>NC_018014.1|WP_014784122.1|236915_237572_+|peroxiredoxin
MSLRINDVAPDFTAETTQGTIRFHEFIGDNWVVLFSHPKDFTPVCTTELGAVATLEQQFANRGVKVIGLSVDKVSDHGKWAEDIKDVSGADVNFPIIGDFDLKVAKLYDMLPAEEGDSCEGRTPANNAPVRTVFIIGPDKKIKLTMAYPMTTGRNFDEIIRVLDSMLLTSKFPVATPANWKVGGDVIITGAVSNDDAAVKFPGYKTVKPYLRTTAQPK
>NC_018014.1|WP_014784121.1|235808_236720_-|PhzF-family-phenazine-biosynthesis-protein
MSTWFTAGRSLDWVQVDVFAERAYEGNMLAIFTDGRSLSDEQMQSLARETNLSETTFILPATPEEEREHGVRVRIFTVEEELPFAGHPTLGTASWLWANHPLLRGGDEVRLKLNVGTIAVRFRTPAEDEAGVYGEMRQRDPEFGPAPDRNELAAACGLAVSDLHTALYPQVVSTGLPFCIVPLASLDALQRMRVDSARMATALAGTAAKFIYAITPHDGAWRARMPFHGADDPATGSAAGCAISYLVRHNAVPSQAAITIHQGIEVHRPSRIDVRASLRDGAVTDVFVGGRTIPVASGTFTHP
>NC_018014.1|WP_014784120.1|234978_235431_-|response-regulator
MRPKKIILCVDDNEQTLSVRKFLLETRGYRVISTTSSHEALEIIDSHAPGELSLLLCDLLMPQMDGVELIRRVREMQPGLPSLMVSGTVTSFERGSGADVFLPKGACSPTELLERVRVLVARKRGPKKHVQSVPLRAIPAASAPTLAQVA
>NC_018014.1|WP_014784119.1|232588_234913_+|ATP-dependent-DNA-helicase-RecG
MLDLATPVQLIKGVGPRNAEALRKRGVETAEDLLYHLPFRYEDRLDPKPLSALKAGEMASVIGEVRGTATLRARSMPIFEMTVGQGLGTLKAMWFRGTYLEGKFRPGQMVALYGKLESSRSTVGSFKMVQPQFEILPGPEDENEAVLLEVGRIVPVYESLGGTTPWGAKLGSRWMRQVVWRLLDDLAAGPQLIDPVPHSLRKRLGLPGRLEALRAAHFPPAGTGMGDLQAFTTPGHARLIFEELFYLELGLELKRKRLRDRAGIAFTADDNVRNAIKQVLPFRPTAAQKRVLGEIVEDMRKPQPMRRLLQGDVGSGKTIVALEAALVAIEGGYQAVLMAPTEILATQHYLSARKLLQRSSRQYKVTLLTGSLDEAEKRRARRRIASGDAELIIGTQALIQAKVDFANLGLVIVDEQHRFGVRQRFTLMKKDEATEPDVLVMTATPIPRTLALTIYGDLEVSVIDELPPGRSPIITRRTSEERADDVWEFVRKQVTAGRQAYVVYPVIEGANDDQPELDFPKDPSESAGQNTGAPTIALKAPAKKAAKKVAAKKSAKKSAKTKKDDELFEKPSLRAATDMYEELRHGALHGLRLGLLHGRLPSDEKEIIMQQFKRGDIDVLISTTVIEVGVDVPNASLMVIEHAERFGLAQMHQLRGRVGRGTAKSYCILMTGGRVSPEAEQRLDAMVRTQNGFELAELDLQQRGPGEFFGTRQAGLPDFRVANLVRDRRLLELAKSEASDFANLRTKNVTEDERAIVRTQLKLHWQRRYGLVEA
>NC_018014.1|WP_014784118.1|232303_232507_-|4-oxalocrotonate-tautomerase-family-protein
MPVIHVHMLGGASHEQKAQIAKEFTDTLVRVLGSNPQMTHIILDEQNPENWANAGELISDRRAKQKA
>NC_018014.1|WP_014784117.1|231375_232299_-|ATP-binding-cassette-domain-containing-protein
MATVVLDKIRKVYETKVAVEGLSLRIEPGTMFGLLGPNGSGKTSSIRMMIGITVPDSGTVTLFDKPFERDALKRVGYLPEERGLYKKMNVMEQITFMGQLRGLSATEADKRGKAWAERLQITEALPKKTEELSKGMQQKIQFITALIHEPELIIMDEPFSGLDPVNGALLQDTLMDLRREGKAILFSTHRMDQVEKMCDAIALIHRGRIVLEGNMREIKSRYPKNRVEVTFEGDNSFLRNAEVESAEEFGGGMASVKLRGDGITTMPDAQPLLAEAVARGTRISRFEVKEPTLEEIFIERVGGAVDA
>NC_018014.1|WP_014784116.1|230098_231334_-|ABC-transporter-permease
MRNIFLIARREYLERVRTKGFMIATILIPLLMGGGITASILIAKHSKSSSHIVIVSPDLALANDVQDQLNRDTEGEMLLNIVAPPSANTLPGLKASLKSKDIDGYLWITPAAQKGAKPKIEYRQGSSADLATRNTVRDALDKVLTRDRLVAQGMSKADVADMMSPITMNAADEEQDSTSANFAGAYVLFFLMYMVIMLYGMNVARSIIEEKTSRVFEVMLATVKPAEMMAGKVIGVGSVGLTQVFIWMAAAVVLTATPLLTHFLGGGTHISLSAAQVGYFIVYFLLGYLLYSSIAAALGAMTNSEQELQQLNMFLVMPLAACMVTLPLVLNSPNSIYARILSLIPFCTPLLMYMRISVSPVPWYEIAASIVLMAITIYVVLWIASRIYRVGILMYGKKPNLPEIVRWMKYS
>NC_018014.1|WP_014784127.1|242970_245793_-|VacB/RNase-II-family-3'-5'-exoribonuclease
MPGHPYPHTDRELLRRVERAGGRAGYKQLVRELGMGGGRERRMLLEQLAKMTARGALVKIDAEQWALPQVHTERVKNDTGRRAVAQDRKRLVHDRSAARSDLIAGKLQLHRDGFGFVRPTDATTQSDGDYFIPPHDLNGAMQGDIVLVLPAPPSRDGRKSGRIMRVLTRRNPTVVGIFHAAGARGRSEDMRLRGSYVVPLDERMTQPVLIENDQDLPSSAITPHRTLGAEAAANDHQWDGTLEDLNGLAVDVEITQYPTDNSPARGRVIEVLGDPDAFGVDVEIIIRKHHLPHVFPAGVLAEAEDAAERNVASLLEEELNLRRDFRDEPIVTIDGETAKDFDDAVLVRKHADNTWELQVHIADVAEYVRDNSDLDLEARLRGNSVYFPDRAIPMLPQQLSNGECSLRPDEDRMVLSCIARIDDEGNVLGYEICEGLIRSARRMTYTNVQKILDGDEEVRKLYEPLLPQFERMYELALKLNGKRVRRGSIDFDLPEPVIDFNELGAMQGVRKAERAWANRIIEEFMLCANECVARWIETSGVPGMYRIHEMPDPKRIIDFEDAAAAFGITLGVGALPVKSVTMKSDRRDQQRRGQQGRVAHKAREHEVSTAAIEVTPHMYQRLAAKIHGRPEERILSYLMLRSLKQAKYSEKNEGHFALAAPAYTHFTSPIRRYPDLVVHRILKTLLADGADPFGDAEEIAAPQGYLGIDEAPKRDVHHGEQQFEDVYPKDELIAIAQECSETERRAADAERELIEWKKIKFMTDRVGEDFDAMILSVTKYGMFVELADMFVEGLVPIFTLTDDHYTYRETTREIRGGKSNKTYRPGMKVRVLLDRIDRGNRRLQFAVIPDHAAGETALPEGVRPFPKRASRSTERREKTVAEAPTRTRKPSPRSAKRSKAKAAPLSSSSPFAKFGADGSSVRKKKNKDRIAASKKKGKKR
>NC_018014.1|WP_014784128.1|245832_246894_-|MBL-fold-metallo-hydrolase
MKPSRLAFALSTVVLAAATAVAQGKGSLRIAAIDVEGGQATLFIAPTGQSLLVDTGWPGRNGRDADRIVAAAKEMGLTRIDTVLLTHYHTDHAGGVPQLVDRIPVGTFLDHGDRYPQDPNSPQDYDDYLKVIASGKSKRVTVKAGDKLPIAGFDAIAISSAGKVMDAALPGAGKPNALCANAPAPAEDTQENGQSLGILLRFAGLKIVDGGDLTSDRERMLVCPANKIGPVDLMIVSHHGIDWSSSPIFIKSLAPRVAIMDNGSRKGASTSVIDTLRSSPRIEALYQLHLAPPAGSPNPGGTKQEGPDHNVPDEFLANPAGTDGKRIDITITPNGAIDVRNERTGDTKHFPRG
>NC_018014.1|WP_014784129.1|247085_247883_-|2OG-Fe(II)-oxygenase
MTPKFLRSDIDFGSLVPAFNEGLPFRHVVIDNFFREDVAKQLAEEFPAFDGPAWSVYHNPIEIKKALNHWDRFPKTTYAVFDFLNSEEFVGEMAKLAGLPLWSDPGLHGGGWHAHAQGGKLNTHLDYSIHPKLGKERILNLIIYITPDWQEEWNGALGLWKDDNGTPGELVTRIPNFFNRAVIFDTSQKSWHGLPDPVESPREKVRNSMAVYYLCEPRKEASERGRALFAPHGDQANDPAVLELIQKRSQVTTSGSVYRTNEDKK
>NC_018014.1|WP_014784130.1|248053_248944_-|glycosyltransferase-family-2-protein
MVACVIVNWNGWRDTIACLRTLKEQTAPLEVIVVDNGSTNDSVAQIKAFLAATPAGSVPITLVEHPENVGFGRGTNIGIRIAKERGAEFAWLLNNDTECPPDTLAKLLRVANEKPDTGIVGTVLYYHHDPSQVQAWSGGRISRWLGTSLHYTSPQPQVPGSYTTFASALVRMQVLDEIGMIYEGFFMYYEDSELCMRMEHTPWKIAVAADTKVLHKEGASTGEARNPFMEKTIAVSGMLFLRMHSPMFIVSLPLFLAIKLLNRARRGEWAAFRAVLRAVAEFQSTPMVPPPVRRRS
>NC_018014.1|WP_014784131.1|249028_250381_+|DNA-directed-DNA-polymerase
MSSADPFASDRRTSAADDRFSFLHVDLNSFFASVEQQIHPEYRNRPLAVVPTFADTTVAIAASYEAKALGIKTGTRVGDMKKICPEIIMVQGDHTTYAEYSHRIHAAVERVCPVAHIPSIDEVTCQLMGREREPPNARRISLDIKQAIYDDVGDTMRCSIGMAPNRYLAKIASDMQKPDGLIGLLPSQLPRALTHLELRDLPGVGAKTEQMLIKKGITTMPQLLELDREGMHKLWNSVWGDRLYHWLRGHDTGDDGAPLPNEMQKSLGHSHVLGPDHRSPQGSWAIAHKLLHKAAMRLRMEKMCTGSLGVTIRYQLSRQEAEGRSKVRQHQSGIKHDAWGMEARFPTCQDTLSLLETLQKVWAQQPTGPEYQRPFFVGVTLGRLIPESEQQPTLFADADNRGALSRTLDKLNLKYGHTTLHFAGMLPARDSAPTRIAFTQIPVQYGVDYM
>NC_018014.1|WP_157178213.1|250783_251332_-|metal-dependent-transcriptional-regulator
MAQTAYASLRRGDFLSTLTAKAKSGVAPIRTSESIDNYLKAVFTLGGDEQRRIGSSELAVRLHVAPASVTNMLQKLAAERKPMIDYERGRGVRLSVSGRRRALEIVRHHRLIETFLFEVLGYPIEDLHDEAEKLEHFISEHFEQRIAAKLGHPDTDPHGHCIPALDGTMPSRHGISCRCGLD
>NC_018014.1|WP_014784133.1|251451_252081_+|hypothetical-protein
MRRNLQLCVALAATSLMVTTGCKGPKDESSNLKSAINSYYDQWPDCLWRNPIQMPQQHDKDDASKVMPFDALVDQGLLSRTPVEKTKLLVLKKEANSYDLTDKGRSNWTADVNQPGYGNFCYAHRKVKDIVSNTPAGTQPGATTTVNYTYTLGDVKDWAQATETQNAFPQLRTALTATNNAKATLTLTNDGWKMQPVAKSAGGDSGIVE
>NC_018014.1|WP_014784134.1|252159_254664_-|DPP-IV-N-terminal-domain-containing-protein
MTTPYLLARKRLCGIARGDRSVAHAPILSALLLVALLPATHAAAQQAVTAADYARAESRMVIHTTPLVDHAVNAATWLKSSDGSDRFWYRDVTGGVSTFMVTDAATGTSAPAFDHARLSAALSAAAGYRTSAADLPISALQMPAANTALLTTIYGDRYRCTLAAEYTCTRQLTMPAQQQAATPTAAVTQPAGNPKPVEGKPATVKEAREKAVISPDGKRAVFIRDWNLWLIDLATGNERALTTDGITDFGYATDNAGWTHSEKPIVVWSPDSRLIATFQQDQRKTGMMYLVGTNLGHPTLDAWHYPLPGDKDITMIERVIIDADAAKTTRLKMPPDQHRSSLCDDISCGGSWEDVQWSTDAKTLAFVSTSRDHKREDVRIADVATGEVRDVFHEEAATYFESGSDSVNWRYLSARNEILWFSERSNWGHLYLYDATTGKQKRQVTSGDWNVSRVLRVDAATGDLLVEGVGREKGWDPYYSAVYRTSLDSNKLRLLTPEQSNHHAAISPDGKYFVDVYSTPQTPPVTVLRDAEGKRLTEIAKTDITRLLATGWQAPENFTVKARDGKTELYGLIFKPSHFDPSKKYPIIDYIYPGPQVGSIGPRIFPLMAGDTHAQGVARSMGGHIALADLGFIVIEIDGMGTPLRSKRFHDSYYRDMGDATIPDQVTGIQQLAAKYSWIDLSRVGVWGHSGGGYATAEAMFRYPDFFKVGWSESGNHENRNYEDDWAEKVIGLDNAANKAAYQDQSTPAIANRLKGKLMLTHGMADDNVPPSNTILVVDALMRAGKDFDLLMIPNAHHGYGDANSYVTRRRWDYFVTNLMGATPPREYPLGPLN
>NC_018014.1|WP_041592823.1|254710_255445_-|RNA-methyltransferase
MSTEVDQQNRVAIVLVRARNPLNIGAAARAMSNFGFHDLRVVNDYDVPFAEARSAIDAAPVLAAARQFATVAEAVADCTLVFGTTALGERRLLHPVDLLRDAAPHAQAALDAGGTVAVLFGSEKTGLSAEEMSHCHRLLTIPMHRGGVSMNLGQAVAVCLYELARGGSSPRTLPDAATPATATELARFESLLREVLVSSEYDRRFPGNMGEDAMRRLVRRLALPGDDVEVWLGMLRQMLWKLRQ
>NC_018014.1|WP_014784136.1|255596_256280_+|MBL-fold-metallo-hydrolase
MKTITHSKNLCQITFLGFSNCWLLREADGFTLIDTSVGGCAEKIVSAARDCGAPIRRILLTHAHGDHIGSLDALRELLGPVDIAISEREAPLLHKDMTLRADEPKGKLKGGYPGAKSRPTHTLTDGELYGSLRCISTPGHTPGHMSFLDERDGTLFSGDALMSIGGLHLVTNPPWYFPLPKMATWDFPLADASARRLLEYRPVCIATGHGAFVGNGTVELERALASL

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Crispr_ID: NC_018014_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_3

1418825-1419178

Orphan

Consensus_repeat	Method
GGCTTTAGCCACNGNGATAGA	CRT

8 spacers

The CRISPR arrays of NC_018014_3

>merge|NC_018014|3|1418825-1419178|CRT
GGCTTCAGCCGCTGAGACAGACCACCAGAAGTTTCTAAGTGGCTTTAGCCACCGGGATAGACACGCAGAAGAGTCGTAAGTGGCTTTAGCCACTGAGATAGAAGCAGCGGGAAAATTCCGCCCGGCTTCAGCCACCGAGATAGAAGCAGCGAGAAAATTCCGCACGGCTTTAGCCACAGGGATAGAACATGCAGAAGAATCATAAGTGGCTTTAGCCACCGAGATAGAAGCAGCAAGAAAATTCCGAACGGCTTTAGCCACCGGGATAGAACATGCAGAAGAATCATAAGTGGCTTTAGCCACCGAGATAGAAGCAGCGAGAAAATTCCGAACGGCTTTAGCCGCCGAGATTCG

>NC_018014|3|1|1418825-1419178|CRT
GGCTTCAGCCGCTGAGACAGA	CCACCAGAAGTTTCTAAGT
GGCTTTAGCCACCGGGATAGA	CACGCAGAAGAGTCGTAAGT
GGCTTTAGCCACTGAGATAGA	AGCAGCGGGAAAATTCCGCCC
GGCTTCAGCCACCGAGATAGA	AGCAGCGAGAAAATTCCGCAC
GGCTTTAGCCACAGGGATAGA	ACATGCAGAAGAATCATAAGT
GGCTTTAGCCACCGAGATAGA	AGCAGCAAGAAAATTCCGAAC
GGCTTTAGCCACCGGGATAGA	ACATGCAGAAGAATCATAAGT
GGCTTTAGCCACCGAGATAGA	AGCAGCGAGAAAATTCCGAAC
GGCTTTAGCCGCCGAGATTCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_014785110.1\|1435439_1436111_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_018014.1\|WP_014785093.1\|1402625_1404425_-\|NirA-family-protein	unknown	unknown	gnl\|CDD\|236573
NC_018014.1\|WP_014785101.1\|1419199_1420000_+\|3-ketoacyl-ACP-reductase	unknown	unknown	gnl\|CDD\|237188
NC_018014.1\|WP_157178267.1\|1408938_1410174_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014785092.1\|1400871_1402629_-\|sulfite-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|273882
NC_018014.1\|WP_014785107.1\|1432685_1434530_+\|cyclomaltodextrinase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|200479
NC_018014.1\|WP_014785094.1\|1404851_1406522_+\|uroporphyrinogen-III-synthase	unknown	unknown	gnl\|CDD\|376850
NC_018014.1\|WP_014785100.1\|1416623_1417436_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_018014.1\|WP_014785097.1\|1410477_1413972_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|379297
NC_018014.1\|WP_014785106.1\|1429231_1432597_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|379297
NC_018014.1\|WP_014785091.1\|1399239_1400844_-\|dimethyl-sulfoxide-reductase-anchor-subunit	unknown	unknown	gnl\|CDD\|319893
NC_018014.1\|WP_014785103.1\|1421728_1424194_+\|DUF4982-domain-containing-protein	unknown	unknown	gnl\|CDD\|236657
NC_018014.1\|WP_169315283.1\|1436107_1437493_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226654
NC_018014.1\|WP_041593055.1\|1434656_1435073_-\|YjbQ-family-protein	unknown	unknown	gnl\|CDD\|223509
NC_018014.1\|WP_014785104.1\|1424229_1426701_-\|DUF5110-domain-containing-protein	unknown	unknown	gnl\|CDD\|269890
NC_018014.1\|WP_014785105.1\|1426810_1429009_-\|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|226233
NC_018014.1\|WP_014785099.1\|1415444_1416620_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_018014.1\|WP_014785102.1\|1420474_1421686_+\|alginate-lyase-family-protein	unknown	unknown	gnl\|CDD\|377511
NC_018014.1\|WP_014785098.1\|1414123_1415410_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
NC_018014.1\|WP_014785095.1\|1406593_1408849_+\|RNA-binding-transcriptional-accessory-protein	unknown	unknown	gnl\|CDD\|225094

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_014785110.1\|1435439_1436111_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	9.76063e-51
NC_018014.1\|WP_014785093.1\|1402625_1404425_-\|NirA-family-protein	gnl\|CDD\|236573	PRK09567, nirA, NirA family protein.	0
NC_018014.1\|WP_014785101.1\|1419199_1420000_+\|3-ketoacyl-ACP-reductase	gnl\|CDD\|237188	PRK12745, PRK12745, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	2.29413e-121
NC_018014.1\|WP_014785092.1\|1400871_1402629_-\|sulfite-reductase-subunit-alpha	gnl\|CDD\|273882	TIGR01931, Sulfite_reductase_flavoprotein_alpha-component, sulfite reductase [NADPH] flavoprotein, alpha-component. This model describes an NADPH-dependent sulfite reductase flavoprotein subunit. Most members of this family are found in Cys biosynthesis gene clusters. The closest homologs below the trusted cutoff are designated as subunits nitrate reductase.	0
NC_018014.1\|WP_014785107.1\|1432685_1434530_+\|cyclomaltodextrinase-N-terminal-domain-containing-protein	gnl\|CDD\|200479	cd11340, AmyAc_bac_CMD_like_3, Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins. Cyclomaltodextrinase (CDase; EC3.2.1.54), neopullulanase (NPase; EC 3.2.1.135), and maltogenic amylase (MA; EC 3.2.1.133) catalyze the hydrolysis of alpha-(1,4) glycosidic linkages on a number of substrates including cyclomaltodextrins (CDs), pullulan, and starch. These enzymes hydrolyze CDs and starch to maltose and pullulan to panose by cleavage of alpha-1,4 glycosidic bonds whereas alpha-amylases essentially lack activity on CDs and pullulan. They also catalyze transglycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules. Since these proteins are nearly indistinguishable from each other, they are referred to as cyclomaltodextrinases (CMDs). This group of CMDs is bacterial. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_018014.1\|WP_014785094.1\|1404851_1406522_+\|uroporphyrinogen-III-synthase	gnl\|CDD\|376850	pfam02602, HEM4, Uroporphyrinogen-III synthase HemD. This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as HemD with pfam00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease.	3.26021e-26
NC_018014.1\|WP_014785100.1\|1416623_1417436_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	6.53363e-31
NC_018014.1\|WP_014785097.1\|1410477_1413972_+\|TonB-dependent-receptor	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	2.00958e-19
NC_018014.1\|WP_014785106.1\|1429231_1432597_+\|TonB-dependent-receptor	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	7.93446e-18
NC_018014.1\|WP_014785091.1\|1399239_1400844_-\|dimethyl-sulfoxide-reductase-anchor-subunit	gnl\|CDD\|319893	cd16371, DMSOR_beta_like, uncharacterized subfamily of DMSO Reductase beta subunit family. This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.	2.9079e-78
NC_018014.1\|WP_014785103.1\|1421728_1424194_+\|DUF4982-domain-containing-protein	gnl\|CDD\|236657	PRK10150, PRK10150, beta-D-glucuronidase; Provisional.	2.74857e-59
NC_018014.1\|WP_169315283.1\|1436107_1437493_-\|PAS-domain-containing-protein	gnl\|CDD\|226654	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms].	4.56519e-18
NC_018014.1\|WP_041593055.1\|1434656_1435073_-\|YjbQ-family-protein	gnl\|CDD\|223509	COG0432, COG0432, Uncharacterized conserved protein [Function unknown].	1.16102e-57
NC_018014.1\|WP_014785104.1\|1424229_1426701_-\|DUF5110-domain-containing-protein	gnl\|CDD\|269890	cd06604, GH31_glucosidase_II_MalA, Alpha-glucosidase II-like. Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This subgroup also includes the MalA alpha-glucosidase from Sulfolobus solfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source.	8.3613e-178
NC_018014.1\|WP_014785105.1\|1426810_1429009_-\|winged-helix-turn-helix-domain-containing-protein	gnl\|CDD\|226233	COG3710, CadC, DNA-binding winged-HTH domains [Transcription].	5.14732e-22
NC_018014.1\|WP_014785099.1\|1415444_1416620_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.34092e-50
NC_018014.1\|WP_014785102.1\|1420474_1421686_+\|alginate-lyase-family-protein	gnl\|CDD\|377511	pfam05426, Alginate_lyase, Alginate lyase. This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyze the depolymerization of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end. This family adopts an all alpha fold.	1.12077e-67
NC_018014.1\|WP_014785098.1\|1414123_1415410_+\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.99926e-52
NC_018014.1\|WP_014785095.1\|1406593_1408849_+\|RNA-binding-transcriptional-accessory-protein	gnl\|CDD\|225094	COG2183, Tex, Transcriptional accessory protein [Transcription].	0

>NC_018014.1|WP_014785100.1|1416623_1417436_+|sugar-phosphate-isomerase/epimerase
MADIQRLSLNQATVQNWSVKEAVDGCVRHGIPSIALWRHKIHEAGLQQSAQHVRDAGLHVSSVCRGGMFVAPSAAERKERIMDNFRAVEEAKELNADSLVMVVGASTEVPIADARQMVADGLAELVPYAREQGVKIGLEPLHPMYAGDRSVLNTIDQSLAMAAPYAADEVGLILDVFHIWWDPTVFEQIQRAAGRIFGFHACDWLVPLPDTLLGRGVMGDGVIDNHALRLAVDAAGYNGPIEVEIFNQALWDTPGDDVLNKVVERFTALV
>NC_018014.1|WP_014785099.1|1415444_1416620_+|Gfo/Idh/MocA-family-oxidoreductase
MQEKRIGIIMNGVTGRMGLNQHLIRSVLAIRNAGGLPIGDGTVLMPDPILVGRNEAKLKAIADAHGVTRYSTDLERCLGDEKDEIYFDSGTTGLRETFVSEAIDAGKNVYCEKPLSTSVESALRLAKKAASAGVKQGIVQDKLFLPGVRKLRRLIESGFFGRILSVRGEFGYWVFEGDWGGQPAQRPSWNYRKEEDGGIILDMFCHWRYVLDHTFAPVQSVSCMGATHIPQRVDENGKTYQATADDAAYGSFQLEGDIFAQINSSWTTRVYRDELFNLHVDGTEGSAIAGLRDCKTQHRVNTPKPTWNPDLPNPFKFREHWQEVPDNANFENAFKVQWELYLKHVALGTPFPHTFVDGARGVQLAELGLKSWAERRWLDVPVIKDADVLKA
>NC_018014.1|WP_014785098.1|1414123_1415410_+|MFS-transporter
MTNAATQKIFYGWWIVVAAFLNLFLAVGVIFYGFPVFYPAFVQALGFSRGQVTQGFLLGFLIVGLPFGLLTGILIDRIGARAVILSGVGLIGLPLIAMGHMHHFWQYQVLCVIEVIGYVLAGPISNQVLIAHWFHERRGRAMGYAYLGLGLGGAAAPPTINWLIRSVGWRHALEIVGAVILIVLFPVGVFLTRSTPADMGLNPDGALAPAALEPAAAGGVFSVIGTAMRDRNFWLILAGSALVIGAMNAVIQHFIFFLVSNGYSSVSASRFLSVLLLASLGGRVIVGYIADRFRKKNTMALFYALLGLAIPILFVAHLPVAAFSFAVIFGFAMGADYMLIPLVTAECFGVKSLGKLLALIIAGYSIGQWMGPWVAGRIFDRYGSYDPAWKFMCGAALLGAAAIYAIRKPRATIMASPEALVIETSSAK
>NC_018014.1|WP_014785097.1|1410477_1413972_+|TonB-dependent-receptor
MKINRILGTASALVLCSTASGVASAQLSTATMFGVVRDASGASVPNATITLTQTDTNFTSKVTAKDDGSYHVEFLPVGPYKLTVTSEGFKTLERSGIVLAVMQNAEVNLALEIGGAVDTVNVTSDVPLINVGNSTLGNTVSNVEIDNLPLINRDVTRLLQLVPGVQSVQTANSLGFQELHVLVNGAADSLVGQTSYYLDGGLNMTGLRNSGNAVPNPDAVSQFNVVTNNYSAQLGKYSSAVVSVITKSGTNKFHGSAFEFYRSRNFNATTHLQGSKNPYNQHRFGGTVGGPIRHDKDFFFASAAAFRFIQYGNYNGSLPSLAQQAGNFSENTPTPAEQANCKATPTAAANTAVHFLVCNPATGLPYANNTLPTVDPTAVNILKYVRANLPTQQPAQFGDTRYTYRTRSPLPEQNNEYLIKTDHQLAAKHRLTLSYFMLDYKVRSVPTTFTQAWSYSDYANKQQNANIAETWTVSDRTVNQFFVGYTRQNGGRNPVPGNSTLADFGSDFGVVGTPSRGQIAVGGVEAFTLGQAITGPKAGSNVYNVRDVLATTRGKHSIYVGGEAGLEKDFQLTSLSNYGSFAFNTANGASGARTTNGLSDFLAGVPTTMAQDTGLYANASYFNYGIFAQDDWRVRSNLTINVGLRYDWQQAPTEPLSRQTNFSPGVQSRAFPNVSIVGKTGPQLAPVGMLFPGDPGVPRGGVFTPRNHVSPRVGFAFDPNGKGTTVFHGAAGLFFGGISGNEWEFPSNFAPYAVRNTYNKVVSLTHPYQGDPTEFPTGTNPYPALSYKGDGNVTFLPLNQVVAFDPNYKWPYSIQINAGFQHQLTSGLAISAYYVGSLNRKLPLYNDINGPQFNINAAGASGASCTDLSKACGYANNSNTVNNRRPLNSQFGASAANPLYSQVYIIRSNQNSNYNGLQVTIEQRLTHRVSARGYYSWSKTLQSNNLNNQGGMNGVFVDNNFPELEVRQRSDQDRRHMMTATVVWKPDYFDNFNHVVRYFANGWTVTAIWTANSGQPFTITTGVDNYFSGNGNNRVSVVPGKTPRVLDNNGSRATAMNQWFDTSAFCRPGVDAGCPGVGPLGLLGNFRAATLDSPGYRNIDTSIFKDFALFREGVKFQIRGESTNVFNLTNLGQPTAAANNTNYGKVTSTSGNNRIIQVGGRILF
>NC_018014.1|WP_157178267.1|1408938_1410174_-|hypothetical-protein
MVIQKTDRERWAPQTEADHTFVWAELEGVLHSPQFSNSKRYPAFLRYVVAQTLDGNGPQIKERTIGIEVFGRSTDYDTNNDTVVRYTAGEVRKRLAIYYHDHEDAALEITIPQGSYVPDFQRVVKPVDAAETAVTPTFDTPVAAYALPVPAALPPAAQVNQWRSLPLVVLVTVVALGLALAFVNHRVQAARTTAVDRFWSPVLHDRGTPLLVPGVVVYSPNPYSGTETAGKGAEYPFVSMQAAAATARMSGLLQKNGSEYELQPANTTTLSDLRDRSVILIGAYSNGWTRRLLQDTRYRLDGPSTPAIRSASDPRQHWERDHNLPYSASDDYAVFGRFRDKTTGSLIVVVAGLGRNGTEAAAEFLTDPHYMAELEERLGKPIGEENMEAVLKISVVDGKTGAPALQAVTVW
>NC_018014.1|WP_014785095.1|1406593_1408849_+|RNA-binding-transcriptional-accessory-protein
MSVPISLDAPYLLHIAQLLNLPLPGIRAVIALSDEGSTVPFIARYRKEATGNLDEVQIRDIAEKVDYFRELLQRRETILASITEQGKLTDDLKARILATMDRSELEDLYLPYKPKRRTKATIAREKGLEPLADYLWNQSPAALDLIALAQSLVDPVKEVATIEDALEGARHIVAERISEDAEVRKATRHLMFEEGFIISRKSFDAVDEQEKFKMYYDYREPVKTIPSHRMLAVRRGESENVLYWMIELEEPRVLGLMRSRIHKADGDWTPHLNQAVEDCWKRLLNSSIQVEIRIELKRRSDAAAIDVFRDNLENLLLAAPAGPIGVLGVDPGLRTGCKLAVVNETGKFLADDVIYPHTGRTKEATDKLAALIAKHNIRAIAIGNGTASRETDAFLRDFLKEKGLANIFRVTVSEAGASVYSASDVARQEFPNLDLTVRGAISIARRLQDPLAELVKVDPKSIGVGQYQHDVDQRQLQQSLEAAIESCVNRVGVDLNTASWTLLRYVSGVTERVALNIVSFRDERGQFRSRSQLHEVPGIGPKTFEQAAGFLRVRDGDQPLDNTAVHPESYGLVEEIAKSLSAPVSDLIRAPHLLSGVKQSSFAAGTFTWNDIVEELKKPGRDPRDTFVAPTFNEAVRDLADVVPGMVLEGVVSNVTKFGAFVDVGVHQDGLVHISEISNRFIKDASEVLKAGQIVKVKVLSADIKTKRIALSIKALQAPSTPTVKNRPVKETKAIPVSDQLAALSSKWRTR
>NC_018014.1|WP_014785094.1|1404851_1406522_+|uroporphyrinogen-III-synthase
MPHASFDSLRVVSLESRRAREVEKLIRTYNGEPIVVPSMREVPLSSNAACLQFGHDLLADRFDAIIFFTGVGVRAMMRILETEFPRENLLEKLRGLTVISRGVKPQAALIELRVPITALAPEPATWHEVMSVLDTTLGDRAAGMRLAVQEYGASNPEMLSELVNRFDSVTKVPVYQWALPEDLEPLRSVVREIVRGSVDVVLFMTAVQVIHLFQVADEISMQDDLRLALASTVVVSVGPTTTEELQQYGVKPDFEPSRPKMGFMINEAAQYAGKLLAAKRASLPPDDLSAALPPPSATRKTPASGVQQVAAMTATMAGFTDGLAPLDILHEIGSRIALADPLHLVLERIVKFACAVIPCDSCFVYTVEGEQLILRASKNPHADQVDTLNVPVGEGITGWVAKHRESVAIPKAASEDPRFSFFALLPEDRFEAMLSTPLVCANRVIGVINVQHRDPYFHSDLQRRLLATLGILVGAEIERARLETENLDLSQRLESRKVIDRAKGLLQAELGITEEEAYLTMQKESRQRRRSMRDIAEAILLSEKLRQKPTMSESRA
>NC_018014.1|WP_014785093.1|1402625_1404425_-|NirA-family-protein
MTDAPSDLTTGDFTDEQKQYLQGFFAGATQRMPFVGHTGAGALTNDPTRADSNLAVATADVEPTVWGTPVSDLCAEEVWKYERNPLDCWDDLLRHAAMDSVPDAEFRYRFKSFGLFHVAPAQDSFMLRMRVPGGVLTSHQMRGLAKMAEQWGCGRIDLTTRANVQLRELQPRNIVDVLNTIQKLGMSSRGSGADNLRNFTASPISGFDAQELIDVQPFADALQNYMSNSRDMFGLPRKFNIAFDNGGSISVLADTNDIGFTAVRVASGRSVPEGVYFRVLLCGITGHKQFASDCGLLLLPDQLVAVAAAMVRVFAEHGDRTDRKKARLKYLIDRWGVPKFLEEVQKKLDFPVIHCDAAECEPRGPIDRAGHLGAHAQSQDGLHYMGITIPVGWLPTEQARALADVADRFSTGELRLTVWQNLLIPNIAAADLEAAKAAVREAGLEYEAGRVLSGTVACTGSRGCRFAMTDTKAHALEIARTLDTMFPIDSPVNLHVTGCPNSCAQHYIGDIGLMGVKVNGGEGYQVNLGGSADNDQGMARELFPAMPYAEVIPALQGVFAIYQQRHEASESFLEFTRRHAVEELRSMCGQQVLSQGDAA
>NC_018014.1|WP_014785092.1|1400871_1402629_-|sulfite-reductase-subunit-alpha
MSVPFLPDNAPFSTEQRAWLNGFLAGLFSAAPTAAAAVDPLQLAVYFASQSGTAERLAKKLVKELKAQGHVAELASLAKVTLADVAGKQHALFLVSTYGEGDPPESSISFRDSLFADGAPKLDAMRYAVFALGDRHYEQFCKFGADVDERLRALGATRLMARVDADVDVDVPFEQWKTALRPHLTQAQVPGVVASTAPVAVACAAESAPASPGHSRDNPFHAEMRERKPLTRDVSSKMTMHLSFGLADSDVHYQAGDACGVIAQNDPELVEEILTLLPFAADTKIEVAKSGVTTVRDALLHHLQPTRLTRKIVQHFAARTEAKPLTTLLLPEEASHLDSFMWDRGLVDLLHEYPGSVSEPAELVSMLPRLSPRLYSISSSPAAHGREVHCTIAVVRYRSHNRERGGIASTMLSDRVRVGERLPIYIQPNKKFRLPASDVPMIMIGPGTGIAPFRAFLHERQALGHGGRNWLFFGERSAQTDFLYCDELHGLRDSGYLTRLDTAFSRDQSHKIYVQDRMKENGAELWRWLCEGAQIYVCGDASRMAKDVDASLHEVIARHGGMNAEAAGDYVSQLHDDGRYHRDVY
>NC_018014.1|WP_014785091.1|1399239_1400844_-|dimethyl-sulfoxide-reductase-anchor-subunit
MALPLHERAMETDSTDLVRMTLLEGGASRALVDALIPSRPLEEGEQYRFHFDMTKCIGCRSCEVACNEQNGNPADIKWRRVGELEGGVWPETQRTYLSMGCNHCVSADCVKGCPVDAYTKDPLTGIVLHSADACIGCQYCVWNCPYSVPQFNPERGVVGKCDMCRGRLLEGREPACVNACPENAIQIEIVNKLEWSENYAAAESPGMPPAGTTISTTRITLPENNVAWLERVDNGHVALEHAHPSLVVMTTAMQATFGTLTALVVAHGLDAIHVTLLVLLTAFALNVSVFHLGRPAYAWRAMKMWRRSWLSREVLCFSLFMLSIVVSAAASWASALGVVWAGPVVQSAAVAGVVFGLMGTLASAFIYLVKARPAWNVVHTPLDFLLSSALIGSVLPAFLQQPADLLGDALGRFGVHLQHAALSAHPLFVVVVAALWVVNLIARVLRLRGSANFESRASYNLLRGEALWWKVALAVAAAVVTPLFFAAPLPFAALLTSITAVAMGRYLFFVSVVPLNMGLTFVGGKQAAHAGAAA
>NC_018014.1|WP_014785101.1|1419199_1420000_+|3-ketoacyl-ACP-reductase
MSSNNNTSGKVALVTGGTRGIGLGIAKRLATSGFHLVITGRRDKADAQDALNDVAQSFRDNTQRVEYQQADVSSATERHSMLDAIDASFGGVDVLVNNAGIAPRVRADVLEATEESFDELIGTNLKGPYFLTQAVANRMIARQQQSTTLRCIINVSSISATVASVNRGDYCISKAGIAMATKLWAARLTQFGIGVYEVQPGVIATDMTAGVKGKYDALIEGELLLDKRWGTPDDVGTAVAMLATGQLPYAPGAVLVLDGGLTLPRL
>NC_018014.1|WP_014785102.1|1420474_1421686_+|alginate-lyase-family-protein
MNPSTHWTRRTFCRAAAATAVLPRRIFAQKSNAGYDLVAKTDRKRIMDAAARYRQEKPETITAVTSPRSPGGPHDFFSEADYFWPNPANPTGPYINRDGQSNPDNFNEHRKRMIRLSIHMPALTASWLLTGNRTDGMLAADHLRAWFITPATRMNPNLQFSQGVHGVSTGRNYGIIDTLHLVEVARAASLIASALMSKADRDALHAWFADYLHWMKTSNFGIAERDTKNNHAVCWALQASEFARLIGDETTRAEVRTQYENLFLPKQMAPDGSFPLELARTKPYGYSIFNFDAMAMLCQSLLDSDKDIYSFALPTGQGICKGAAFLYPYLKDKSAWPYAKDVQHFDSWPVRSPGLLFTGLACRRDEYLALWKTLPADPTDPEIIRNYPVRQPLLWFGKAPARA
>NC_018014.1|WP_014785103.1|1421728_1424194_+|DUF4982-domain-containing-protein
MTPTRRAFLVGSAALCATTLVSSRLMAASTTTTPDVTILDKDWEFYRGPLEPWQVWHSEELVTWEPQTVPHCFNHYDACDPDIPAYRGSGWYRTKLKAANPYRDGRTMLLFEGAAQTSEVFMGTTSVGKHIGGYNEFAVDITDALKTSKDGALAIHCSNARDLDRMPSDLSDFTLYGGLIRPVHLVYLPELAIESIYSVPEWHPGDTSATVSVTARLSGNTTRTASQIPFTIKLIDSSGKVVTQQKLSKNAGQAEFELATLTIPAVQPWSPETPTLYRCEVTMGTGADTSVTTHRFGIRHTKFEAQGPFLLNGKRLLLRGTHRHEDGAYYAAAMPADQVREEFRLIKAMGANFIRLAHYQQSRQVLDLCDELGLLVWEEVPWCRSGVGSATFQQHGKDTLTAMIDQHRNHPSVLMWGLGNEDDWPGELNGDDREAIRTYMRELHELSHKLDPSRVTSYRRCDFARDIPDVYSPSIWAGWYGGRYTEYAAALEKARKAVPHFIHMEWGADSHAGRHAEDPDPALGTVATGKGTAEKGFDYKLTGGTQRMAKDGEWSETYACDLFDWYLKTSESTPWLTGTAQWVFKDFTTPLRVENPVPRVNQKGLITRDMQLKEGYYVFQSFWAKEPMLRLYGHSFPLRWGKARQKRTARVYSNCSEVELFLNGKSVGRRKRDPNDFPCAGLRWELAFTEGRNELRAVAHEGGKTLEDTVQFRYETRPWSKPVKLLLRTVATQNGRSTVEAELVDVAGVRCLDSRAVVRFSLAGDGRLIDNLGTPDGSRVVQLANGRARITVDHREAVVVGVSSDNIIPGYQELGKHNGQA
>NC_018014.1|WP_014785104.1|1424229_1426701_-|DUF5110-domain-containing-protein
MSRCAVRLLFPTAVFLLPLAALAQQIRATPNGLTATEDGTTLEVTALQADKLRIREWRSAPPEDASWAVLPASRTSRATVAADVRGFHTDKLSVEISTGLHLIIRDHHGNVLQEDSTPVQWRGETFHIYKQRGENEHFFGLGDKPGPLDRAGQEFTMWNTDDFGWQESSDPIYKSIPFFMDVKDGRSFGILFDNTWRTSFDFGRESAQEYNFGSQGGPVDYYFLYGPEPKQVMASYAWLTGPAPLPPLWSFGFQQSRYTYSPASQLLDVAAHLRKDKIPADALWLDIDFQKNNMPFTVDPVGFPKFPELVQQLAKEHFHLIVIADTHIADKPNAGYVPYDSGTAGDHFLKNPDGTTYVGKVWPGDSVFPDYTQARTRKWFGTLYKDFVADGVSGFWDDMNEPAVFRYPSKTMPLDTQHRIDEPGFAKRTASHREVHNIYGLLNSQASYDGVLALRPNERPYVMTRATYAGGQRYAVTWTGDNSSTWNHMRMTTPQLINLGISGFSFAGADVGGFAGSPPADLLTKWLEIAAFQPIDRDHSAKGTRMHEPWVDGPEQEAIRKRFIEERYRLLPYMYTVAEETSRDGMPMMRPLFMEFPHATADGSPMDLVTGGAEFLLGSDLLIAPNPSPEEVAPYELHLPPGTWYDYWTGARAGTRSVVQTRDSEVRDSLLASQQTMLTPELAKVPVYARGGAILPLQPLVQNTDETPNGPLTLRVYVPSAGESCSGTVYSDDGHSLNYRKGDFFRMNASCSVSADGLLSVTLDPAEGRYKPWFKQLRIELVGSQRAPQRASIDGKEAALASTGAVPSITFDWNAKGSRITFQ
>NC_018014.1|WP_014785105.1|1426810_1429009_-|winged-helix-turn-helix-domain-containing-protein
MRQSTHSVRVAFGTFEADLSTGELWRGGFRIKLQGQPFRVLAELVQNAGQVVTREELQQRVWEPGTNVDFDHSLGTAVNKIREALGDNADNPRYVETLTRRGYRFIAPVTVLETAAAPATIDIATPPPPDLAPSVPTLPTSPTAMMSVQEVSRTPSTINRLWVAGAAIALILLIGVFCGFLIGRPAGAPQIPSLRQVTHSQRVLPGGDAMEVFPVTVTDGLHLFASVIRDGSVHLARITIAGGAGEPIVLPDEIAGPAIADISHDGSRLLVRSHASNQSEQPLFIVPSGGGSAQRIVRILAHDATWMPDDKKILYATGNQLLVAGPDGSEPVLFATLPGRAFWLRWSPDGKVLRFTLFDPIPHTQALWEMTVSNHTAHPVLSKWAEANGVCCGSWMSDGSFVFQAAQGPASDLWLLAPRSSNPVRLTDGPLTYQGPVAARSERTIFLTGVSTEGEVQQLKPGARDFAPVRNFYSDAHRLEQSRDGKWLAWVDTVGRLWRARSDGSEILQLSPGDLQVFNAHWSPDGSRMALMARKASGAWSIYQEFADGSDLQPLLESGSNTADPTWSPDGQTIVLGLAPDLLGKDAAPRTIQLLDLKSHRVTTLPGSDNLFSPRWAPDGRYIAALSLDQRQVKLYEVATKQWRVLSGRSAADPVWSADSHYLYADAFMDAGQPVYRVAVADGRIEELGGMDRLRSSEFSDMVLAGTLLDGTIVVRARSTTANLYALGLSTR
>NC_018014.1|WP_014785106.1|1429231_1432597_+|TonB-dependent-receptor
MRSKSKSFGSHLYVTAATLSLGFASISVQAHAQTDTGRVTGTVVDPTEATIPGATVTITNTGTSETQTVKADAAGNFTFPALQRGPYKISATMTGFQTTTQSFDLQVSQVQTVIFKLSVGSTDQTVEVTSAAPMVELGSSTIGSVVESRQQTQLPLNGRNFTQLALLSPGVTRGNYGNGASGVNGDAETFRNSSSGGGSLSTNGLRPQANNYILDGVDNNEGLVNTLNFFPNVEATEEFRVNTSTAPAEFGRAGGAIVQTSIKSGTNSIHGSAYWFSRSNLFDASPNYQFLGASKTAPLPFKRNTFGGAIGGPIIKDRLFLFGDYSGLRENSPLNPEIVTVPTAQMRQGNFQELLGRGTTQAPTVCGRPGVTTVAVNGGIYDPTTCQQFANNIIPQGRLNSAGLRYLNAFPLPNIPGTLGGTQNNYRTIRTDVRHSNTIDGRLDYNISTADRLFARFSYDNSNFTRSSRFAALPAGFASGTNYVHARGYVLGETHTFGPNTINEFRAGYTRYTFANQPVFSNTPISANLGIVNANRTTNLGGGALIGGNGSQLEYTGDYGTYLVPENTYQINNALTYIWKGHTFKVGGNGIRREVAYFRPISGKGYFQLGNGDFTGYNTSEVLAGFADNYSIGAQSGLFGTRNYEVGAFAQDDWKLSRRLTFNLGFRWDLITYPTEQQNRQAALNPNSTGANPTELIAGQNGVGRSIINTRFTNFAPRFGFSYDLTGQGKTVLRGGYGIFYFLDRGGIDNQLGQQVPFGGSTSYFASGGSRIAFTGQNPTGSSLSSTLATAPLPGPTTSSLAGANVFAVNQTEKIPTVQQYDLQIQHEITPKMVMTVGYVGNLSTHLATGYNFNSKPFSAGATTPTAFPTLGQVVYNLNDGVSRYNSLQAQLNYRANKSLTLTSSYTWAHNIDNTNGYLGFYAVSDLNYYDHSLNKGNSSLDQRNVFVASALYSIPFGRGQQFGSNINRGLDYIVGGWQLNTIVQAQTGTPFSVTFPVYGGGTSIRADYANNGQPIYTHSIQGNYINPAAFSKTQPNGRQGNTGRNQFYGPGFAAGDVSMFKTLGVTERLKTELRAEVFNVTNTPQFQNPDGTITDGNFGKVTATRLASERQMQMAIRFLF
>NC_018014.1|WP_014785107.1|1432685_1434530_+|cyclomaltodextrinase-N-terminal-domain-containing-protein
MFARPVVASCLSLIFASALSLHAQAPRITKVDPPNWWVNMPAPMLLINGEHLNGAKFSVGGLPIERTTISDNGHWAELWLAKDATSVGDLRITAQTTQGKAEVPFRFEPRRAANDGFAGFSSRDVMYLIMTDRFADGDKTNDGPDAKDSADSAAAQAQRKEGRGWHGGDLRGIEQHLDYLQALGINTVWITPVYQNHDHDSYHGYGATDMYAVDEHYGSLEDLKSLSKALHARGMKLVLDTVPNHVGPMHPWVNDEPEPTWFHGTKVKHTVAQMDFQPLTNSHAPWSTQRDVTEGWFVDTLPDNNQSNPANAKYLVQNAIWWTEQAGLDGLRIDTFPYVQRDFWTQFNSTLRTLYPKLTSVGEVSGTDPIINSSFAGGVTRDGVDTGLWTPLDYPLHFAIRNAFTGASPMTELVTILRQDSLYPHPERLVPFLDNHDLIRFASEPNATLAGGKLAMTFLLTVRGMPQLYAGNEIYMDGYQDPDNRHDFPGGFANASNDVFQASTRQPVQKEMFDWTSGLLALRSKTPALQTGTLQILYASTDSLVYTRTEGKQRVLIAIHRGSEDVTLHLPTLDTSITGANAATRLYGEGELTFGSGDVAVALPANSALIAEIQ
>NC_018014.1|WP_041593055.1|1434656_1435073_-|YjbQ-family-protein
MNQSVRTIVLTTRGQGLYEFTETLSSWLSEQEIQTGLLTVFCRHTSASLLIQENADPTVQHDIKAYFSRLAPENGPYEHNDEGADDMPAHLKTALTQIQLSIPLVNGRLVLGTWQGVYLFEHRVRPHRREIVLHLIGE
>NC_018014.1|WP_014785110.1|1435439_1436111_-|response-regulator-transcription-factor
MSDLQTPIRILLVDDHTLFRESLRRVLEAEAPFRVVAEASTLEEATAYCTGGGDFDLGLVDFQLSSSDPAKNGLAVLRAIRQTNASAAVILLTAGTGKAELREAVQTYAASIFLKSEPTSDLFLAIERTLEGRRWISSGANRLLLEESSAPSASAPGEAAFTARELMVLRWITEGLSNKEIADKLTISESSVKALLQKLFEKTSVRTRSQLVRYVFECGLTLP
>NC_018014.1|WP_169315283.1|1436107_1437493_-|PAS-domain-containing-protein
MTHWRERPATVALAAAILAAAISVFDRLLPHDVPLSLLYLLPMGMIGSVASRWQVLSAALLCTGIAEYSDAFAWSASAGIPRDLLSFIAFASEGLYIREALSKRQSERRNIKLLQEENQARREAEEQLSLLIGSSALAILTLDGTGLIIQANQAARQMFQEGACGDESLLGIGVTTLLPALGRVPHRSHPERPVKTMMQTQGFRRDGAPFLAEVWFSTYTTTHGPRTAAMIVDASDDLRDREESALEQLLNSSRLAVGAVAHEIRNVSSAIQLVQRNLLTTTPALGDTPDFIALQQLTSTLERMASVETSQVKRTATILPLQHCFEELRIVSQAMLRESDIALEWNVPADLPSAWADQQGLMQVFLNILRNAQSALASTADAKVRVDFIRNAKTVSIRISDNGPGVATPESLFRPFWAAPTTVSFGLYLSRAILNSFQADISYEPLNPGASFVIALQVASL

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Crispr_ID: NC_018014_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_4

1609963-1610053

Orphan

Consensus_repeat	Method
TTCGCGGGCTGTAGGCACACGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018014_4

>merge|NC_018014|4|1609963-1610053|CRISPRCasFinder
TTCGCGGGCTGTAGGCACACGACTTCCCAGCCCAGGGCAACGCCCTGGGTCGCAAAACACCGCACGCGTTCGCGGGCTGTAGGCACGCGAC

>NC_018014|4|3|1609963-1610053|CRISPRCasFinder
TTCGCGGGCTGTAGGCACACGAC	TTCCCAGCCCAGGGCAACGCCCTGGGTCGCAAAACACCGCACGCG
TTCGCGGGCTGTAGGCACGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_014785247.1\|1617904_1618792_+\|SCO-family-protein	unknown	unknown	gnl\|CDD\|239266
NC_018014.1\|WP_014785244.1\|1610187_1613835_-\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|224000
NC_018014.1\|WP_014785235.1\|1597407_1598250_+\|phosphoadenylyl-sulfate-reductase	unknown	unknown	gnl\|CDD\|234997
NC_018014.1\|WP_014785243.1\|1609083_1609746_+\|phosphate-signaling-complex-protein-PhoU	unknown	unknown	gnl\|CDD\|273990
NC_018014.1\|WP_014785246.1\|1616603_1617821_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340891
NC_018014.1\|WP_014785236.1\|1598322_1599087_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_018014.1\|WP_014785249.1\|1620804_1622913_-\|oligopeptidase-B	unknown	unknown	gnl\|CDD\|224684
NC_018014.1\|WP_157178582.1\|1618902_1620786_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224055
NC_018014.1\|WP_014785245.1\|1613828_1616585_-\|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl\|CDD\|274682
NC_018014.1\|WP_014785239.1\|1601303_1603880_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|379297
NC_018014.1\|WP_014785237.1\|1599159_1599597_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_041593087.1\|1624618_1625188_+\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
NC_018014.1\|WP_014785242.1\|1607522_1608911_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|274368
NC_018014.1\|WP_157178280.1\|1606766_1607510_+\|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|223816
NC_018014.1\|WP_041592493.1\|1625284_1626289_-\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NC_018014.1\|WP_157178279.1\|1603986_1604346_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_157178583.1\|1623842_1624562_+\|TPM-domain-containing-protein	unknown	unknown	gnl\|CDD\|224429
NC_018014.1\|WP_014785240.1\|1604740_1606609_-\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|372624
NC_018014.1\|WP_014785250.1\|1623116_1623629_+\|DUF4142-domain-containing-protein	unknown	unknown	gnl\|CDD\|379301
NC_018014.1\|WP_014785238.1\|1599735_1600713_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133030

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_014785247.1\|1617904_1618792_+\|SCO-family-protein	gnl\|CDD\|239266	cd02968, SCO, SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c oxidase (COX). They contain a metal binding motif, typically CXXXC, which is located in a flexible loop. COX, the terminal enzyme in the respiratory chain, is imbedded in the inner mitochondrial membrane of all eukaryotes and in the plasma membrane of some prokaryotes. It is composed of two subunits, COX I and COX II. It has been proposed that Sco1 specifically delivers copper to the CuA site, a dinuclear copper center, of the COX II subunit. Mutations in human Sco1 and Sco2 cause fatal infantile hepatoencephalomyopathy and cardioencephalomyopathy, respectively. Both disorders are associated with severe COX deficiency in affected tissues. More recently, it has been argued that the redox sensitivity of the copper binding properties of Sco1 implies that it participates in signaling events rather than functioning as a chaperone that transfers copper to COX II.	1.46537e-30
NC_018014.1\|WP_014785244.1\|1610187_1613835_-\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	6.79374e-79
NC_018014.1\|WP_014785235.1\|1597407_1598250_+\|phosphoadenylyl-sulfate-reductase	gnl\|CDD\|234997	PRK02090, PRK02090, phosphoadenylyl-sulfate reductase.	2.52414e-78
NC_018014.1\|WP_014785243.1\|1609083_1609746_+\|phosphate-signaling-complex-protein-PhoU	gnl\|CDD\|273990	TIGR02135, Uncharacterized_protein, phosphate transport system regulatory protein PhoU. This model describes PhoU, a regulatory protein of unknown mechanism for high-affinity phosphate ABC transporter systems. The protein consists of two copies of the domain described by pfam01895. Deletion of PhoU activates constitutive expression of the phosphate ABC transporter and allows phosphate transport, but causes a growth defect and so likely has some second function. [Regulatory functions, Other, Transport and binding proteins, Anions].	2.30793e-56
NC_018014.1\|WP_014785246.1\|1616603_1617821_-\|MFS-transporter	gnl\|CDD\|340891	cd17333, MFS_FucP_MFSD4_like, Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins. This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.03747e-17
NC_018014.1\|WP_014785236.1\|1598322_1599087_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	3.04958e-23
NC_018014.1\|WP_014785249.1\|1620804_1622913_-\|oligopeptidase-B	gnl\|CDD\|224684	COG1770, PtrB, Protease II [Amino acid transport and metabolism].	0
NC_018014.1\|WP_014785245.1\|1613828_1616585_-\|PD-(D/E)XK-nuclease-family-protein	gnl\|CDD\|274682	TIGR03623, TIGR03623, probable DNA repair protein. Members of this protein family are bacterial proteins of about 900 amino acids in length. Members show extended homology to proteins in TIGR02786, the AddB protein of double-strand break repair via homologous recombination. Members of this family, therefore, may be DNA repair proteins.	0
NC_018014.1\|WP_014785239.1\|1601303_1603880_-\|TonB-dependent-receptor	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	9.4047e-20
NC_018014.1\|WP_157178280.1\|1606766_1607510_+\|winged-helix-turn-helix-domain-containing-protein	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.59565e-83
NC_018014.1\|WP_041593087.1\|1624618_1625188_+\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	3.0942e-71
NC_018014.1\|WP_014785242.1\|1607522_1608911_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	3.561e-84
NC_018014.1\|WP_157178582.1\|1618902_1620786_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.57629e-164
NC_018014.1\|WP_041592493.1\|1625284_1626289_-\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	8.37527e-90
NC_018014.1\|WP_157178583.1\|1623842_1624562_+\|TPM-domain-containing-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	7.65944e-46
NC_018014.1\|WP_014785240.1\|1604740_1606609_-\|amino-acid-transporter	gnl\|CDD\|372624	pfam13520, AA_permease_2, Amino acid permease.	1.50993e-11
NC_018014.1\|WP_014785250.1\|1623116_1623629_+\|DUF4142-domain-containing-protein	gnl\|CDD\|379301	pfam13628, DUF4142, Domain of unknown function (DUF4142). This is a bacterial family of unknown function.	2.03329e-24
NC_018014.1\|WP_014785238.1\|1599735_1600713_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	1.25214e-89

>NC_018014.1|WP_014785243.1|1609083_1609746_+|phosphate-signaling-complex-protein-PhoU
MRKRFHQSLDELKEKLLVMAGFSEQAIQRAIEAYRTRDGEMVELVRKSEPSINRLEREIDSTALDLLATEQPMAVDLRFILSVIRINADLERVGDLAVNIAVRVGETNALQPVDLPVDIPRLGTLAAAMIRKALEAFIEGDAEMAESVLALDDEVDRLNSAAFHALSRVIREQPAVTTQALNAMLIARNLERVGDHATNIAEDVIFWVKGNDIRHKMTAA
>NC_018014.1|WP_014785242.1|1607522_1608911_+|two-component-sensor-histidine-kinase
MRRFFKNPLTLALACFSLGALLIVLIPRHPELRWFAVAVFASVSLSAGMALRRQFRMRADSAARAVAGIVGRHQNSAGAPLAPVLDLRNTVDGRGPVFDPVLRAARDAAEYIATERARLEQRGNQLEVLLEGMPDAVLGVDAAGRAQWSNGQMQRLMGRDTAGVSVRHGRALVHTFRDPALLAAVQKTLDEGVTSQCRSESIVAGHIFQVNASPLPGGGAVVVLHDNTQAEQMERTQRDFVANVSHELRTPLTSIVGYVETVLDHETLSGPAREFLDTVLKNASRMHRLTEDLLLLTRVERADNPLEPQPVAAEQLLRDALSMVSGSTYAEGARLEVGGSTRRLVRADEHAILQVLGNLMENAVKYSSGGVESPRVIVSARELEGEVEFCVQDFGPGISSEHLPRIFERFYRVEKARSRATGGTGLGLSIARDLIQQHGGRIWVESALGEGSTFRFTLLFAD
>NC_018014.1|WP_157178280.1|1606766_1607510_+|winged-helix-turn-helix-domain-containing-protein
MSQTIFLLEDDADISRLVRYHLEASGFTVQSFANAGEVLPAAERKAPSLFLLDIMVPGGDGLDLCRRLRLNATLSSVPVIFLTALATESDRVHGLELGADDYITKPFGTRELLARVKAVLRRFERQEPAETLRVGEIEIDGSAMQLRVRGELVTTTATEFRLLDYLARHPGRVFSRDQLLDAVWGDARFVTPRSVDVYVRRIREKIEDDAEEPRYLKTMRGAGYRFERADKISQVPAVPTEAAVERA
>NC_018014.1|WP_014785240.1|1604740_1606609_-|amino-acid-transporter
MTFSDWLLADLRVPTPHVEHEAQNPWWRVMCLTGVDYFSTLGYQPGIAFLAAGVLSPVATLVLVLVTLFAALPVYRRVCKASPYGQGSVAMLQRLFPAWGGKIFVLVLLGFATTDFVITMTLSAADGANHLIHNPLMPAWMDHQMVVTLLILTILSGIFLKGFKEAIGVAVWLVGSYLVLNAVVVCAGFWEIIKHPSVLHHWRMAIGERHQSIPVMIGLSLLLFPKLALGLSGFETGVAVMPLIKADSDEERIRNAKRLLATAAGIMSVFLIATSVITTVLIPAKEFAKGGEANGRAMAWLAHQYAGNVLGTAYDISTILILGFAGASAMAGLLNLIPRYLPKFGMAPEWARASRPLVLVFMGIATVVTLLFNADVDAQGGAYATGVLVLITSASVAVMLSVWKTKLRWAFIATTAIFTYTTLANIVERPEGLKISSIFIGCILLSSFISRALRSTELRISDVQLDEETDSILAEDADQIIRLVARGPEMGDSVELLDVADWKVRHFHNLSDEECLFFFEVIRGDASDFSETLCVTGRRVGRHRVLSAKSPVVANSIAGMLIYLERRTGKVPHVYFRWTQVSPAVNIMRFLFLGEGDTAPLTQEVLRKAIPQQERRPVVHVS
>NC_018014.1|WP_157178279.1|1603986_1604346_-|hypothetical-protein
MQLPARDRSSSAFSRACAVLCLLLLMFSFGHTAAGHADALAAPSLHGMGLTLSQAGDPAGPDSADACALCVALSTIVALAVFAFGIPRTARPRPIFRVTPTGPVTGWHASLFCRPPPTV
>NC_018014.1|WP_014785239.1|1601303_1603880_-|TonB-dependent-receptor
MRMGRFAFMLALSPALAGVSVVAQGNTGTVTGTVADTTGAAVPNATVIITNPVSGLRRTATSDGAGHYTFPNMPFNRYHVEASAPGFASASGDAQVRTGSATTVDLKMTVGAASQEITVEAEDVLNTSAQQANTIDRDLFSKLPLVSTSSPLSSLVTLSTPGIASDSNGLFHPLGEHADTTFAIDGQPISDQQSRVFGNQPSPNIIQSVNVINGIAPAEYGDKTSLVVETTTRSGLGQLKPTGTISLGYGTFGTFSPAIAFGMGGAKVGDFFSVDGFRSGRYLDSPELRPLHDVGNNQNIFNRADWHPTDKDALQLNTTFSRSWFQQPNQYDQPTQDQRGKIISFNIAPSWTHTINATSLFSMSPYLRQDNFHYYPSHDILDDSPVTLSQSRRLQNVGFKANYTVTKGIHTIKAGATIYHTFLSEGFGLGVTSAAFNAPCNDADGNAVTDPAVTSQTQCGVGNAYVANDGYAAGLAPYDLTRGGALYRFHGRTDIKQEAAYVEDNITWHNLNLQLGARADNYNGLSRRSLVQPRLGVSYHLVSTGTVFRFGYGMFFLTPYNENLLVSSSTGVGGLQSTAADPLTAVPLKPAARNQFNAGFEQAFSHFVVVNAEYFWKYTDRDFDFDVVLNSPLAFPIQWAKSKIDGLGVKVSIPNYRGFSAYSAIGHTRSRFFGPEVGGVLSNDPTINSSSVFRIDHDQAFQQSSNFQYQFKHGPYAGLTWRYESGMVAGAATDAAAVLGFTPDQQAQMQLQCGNVKATLAAPITSCAANLLSSPLIKIPAPGTENDDKNPPRVAPRTLFDAQLGWDNVLHKDRYKTNVSIVGTNLTNKVALYNFLSTFSGTHFVSPRTVTGQIALTF
>NC_018014.1|WP_014785238.1|1599735_1600713_+|glycosyltransferase-family-2-protein
MPKYSIVVPFHNEEDNVTALYDRVKDVMEHVGETFEMIFVDDGSRDRTYRLLEEIAAVDSRVLVIKLRRNFGQTSALAAGFDHAQGDFVLAMDGDLQHDPREIPDFLAKLEEGYDVVSGWRAQRADNFVMRRIPSRIANWLMAKLSGVDIHDFGTTFKAYRREVIQNIPLYGQMHRFIPALASWYGASICEIPISNPPRVAGKSHYGITRTFRVFFDLLTIRFLLKYMMRPLHFFGSFGAISVLAGIIMALWLGIMKLVTHGHMLLQHGPWFIMASVLILAGVQLIGIGLLGELQVRHYHSPQHRAPYAVERIVRLRSSEETMLS
>NC_018014.1|WP_014785237.1|1599159_1599597_-|hypothetical-protein
MGKRIFGIVVALLAVYLIYYAYQRRMISQSTDGSIKIGDTDDATAKDGSSNELQTPAPKPRATVENPLNSTMPAAAQTPVAARDSIQPNPPNGVAFAGTGKFQVYRQGNLTWRVDTESGANCILFATMEEWKKPVVYHHACGDSR
>NC_018014.1|WP_014785236.1|1598322_1599087_+|sulfite-exporter-TauE/SafE-family-protein
MHYLIGFIIAMFIALTGVGAGTITTPLLILFLGVPTSIAVTTGLVFAASVKLLLVPTQIIRKQVDWKVLGWMLLGGLPGVLVGSFFLAHLVSKGSQHFMNGLLGAVLVGTAIYQIFYSFRPIKNPREITRDAPWAMPLLMFPVGAEVGFSSAGAGALGTAALLSLTTLAPAMVVGTDILFGFLVAVIGSGVHMFNGAHDTQLLKELIIGGIGGVIVGTVSAKYIPKRPLRFALWVWLLIIGVQFLYTNMIGVTK
>NC_018014.1|WP_014785235.1|1597407_1598250_+|phosphoadenylyl-sulfate-reductase
MSQLPIDTTEVVSREHEKQVLRAERETERAGGAPLPDAPIVDTADLRPELLAQLAHVRQTLQDELSPVGPEEACLTCSFQAEDVLLLHLAMELRPNIPVLFLDTGYHFKETYEYRDRIAADWHLNLTNLLPRQTVPQQESEFGLLYQTEPNRCCGFRKVEPLFDAVAQYKVWLTGLRREQARSRTALKEIDDFAVKPGIIVRKLSPFADWTTRDVWQLCAHFDIPLLPLYDLGYTSIGCEPCTTLPTDPNDPRSGRWAGKKVECGIHIQATEDGNPDASH
>NC_018014.1|WP_014785244.1|1610187_1613835_-|UvrD-helicase-domain-containing-protein
MVIEFPVSDREEMSDASERSAALDITTSCIVEAPAGSGKTGLLIQRFLKLLATVDEPAQVLALTFTNKATAEMQERVLGALSATADGSAKDDGDFARLTKELAEAVLARDAERGWRLLQRPQRLNIRTIDSLCGEIARSLPLLSGEAGVTRPVQDARPLYARAARVVMMQFGGNDEPLNAAVRTVLLHRDGDLLFCERVLAEMLGTREQWGSLIPLGEQLTEEHLEQVTLPRLNASLERVVCGAMEELRDSFDEESLLEIAAITEQLAYADGYKDYPHPFRECGGMPLPPGCGPDQLRYWKAIAHALLTKDGWRASHNTNHVYAVIETKAKARLKDLIESIQSDELKDLLNTVRGFEGAVYPREQWEVAKALFRLLERALVELQLLFAREGVCDFTEVALAARTALKENAFEAQSALGAPLRHLLVDEMQDTSSGQYELLQTLTSGWDGASQTVCLVGDPKQSIYLFRQARVDRFQRCMTTGLLGEIGLNVLRLSSNFRSTRTLVDELNGAFTRIFPEHHPLEGDVEFHPATAAKDPVDGDGAQWHLKAVPPGDGLMENRRVRRRAVREEARAIASTILRWRAEKGESSSVAVLTRARTHVTEIAKALRKVGVPYRAVDLESLAERQEVLDIMAVTRALLHPADRVAWVALLRAPWCGVELAHLHTLVAGDDRQHRSEALRLRLRERAAMLPGAAGARVLRTLDVMDGAVRHAGTAALADRVDRTWRSLGGDLCTDDVGRENVRQFLRVLDAMEADGEAVTLPSLNRRVERLFAQAGHAANAVDIMTVHRAKGLEWDLVIVPGLHRPAGRDAFTALEWLEIANSDDVLLAPLPAKGGQAEAVLQYIRKRRRERVYLELKRLFYVAATRARVSLHLYGAPMADSKGSPIVVKGTLLSAARPAAMLEFQTAAGIPVEEAPTRGIALVDEQDTFETGALALAASIAVEDEEEKVFHLPSFQRLPDHVDPIASLHASQPAVASLSADALAPRQRFVRPQGTFGARAVGNAIHAFVERLSQAVAGSIGSGEAANNALGRMEREVPQWSAAIHAMLRSGGLPPAAVERAAGTVERALLNMLRSEDGRWLLLPHRMAANEAAWRSGVSGEEVRVRLDRSFFAGSKPGAAGDDTLWIVDFKTADRAAAEQDAFLAEERVAYEQQLRAYAAIRLQMLPAGTPVMLALFYPLMGRMVSWRYEASEVASSEVVIVANGTGQFSLFG
>NC_018014.1|WP_014785245.1|1613828_1616585_-|PD-(D/E)XK-nuclease-family-protein
MSDRPATQPQPAGSVHLSLRIDAALKRGAFVLTPNLRTARRLAAQFDDARRAEGLLAWQPANVLTWSAWTTSLWQSALIAGSETRVLLNDLQERAVWQRVLQQDATQSLRPLVSQARLCSGALRLLGAFDTANRFGRITTQDVFSDTATFANWYARFTDLCAAEGLLPTSHLDTEIAGLLRDGRMTAADEYILYGFDRLTPAQRVVTDALQQAGSLLQHVAPSRNQAASPRLLACGSPDDELQACSAWAREALADGERVAILVPDLETTRPELERALRSAAAPALADVTASVRPAPYEFSTGRPLSQVAMVADALRLLRWCAGSIPVPDAGAVLCSPNLSVAPSPERGAELDAFVLRDASADLLRAEVSLAEAASILFKRDADTAGALRGIASAARPLDSTRNSHAYFADESRKLLQRAGWPGVQELSSTEYQAIDRWEEALDRLSTLDLLGGRTTFANFLDDLTDLARETLFAPENTGAPIQVMSITEAAGNTADALWFLHADDATWPPRRAMHPLLPSALQRSLGMPGSEADRDEDEAREAMMRCVRSASRTTFSYASSAAEGHRRSSPLVEAMPGIVFEFATVDEAAEAPAQIESVEDTMPLPPLPAGVAAGGVSVLTAQAQCGFRAFAEGRLFVRELETIDAGLSPRDRGEQVHTALQAFWDTVKTQAELIRISRKDATGDRKRDALLQSCIEKAFEKTPANQWDAAYLQVQRERLFKLLSSWLDVEAQRPPFTVLHTELKVPGAQVGPLRVDMRVDRIDRVGSEEEGTGATVLIDYKTGVAERKDWIGDRLEAPQLPVYAIAGGIDDVRGIAFGSVRVQKDGMKFDEMAERAGMIGPATRTKRDLSFDERMEEWRRDLQRLAEAYANGEAAVDPKDHLITCKHCASRPICRLDLTQLEPDDDLTEEEDEAPAW
>NC_018014.1|WP_014785246.1|1616603_1617821_-|MFS-transporter
MGQIPDERTTASDQTSAEIAAGASPNLALLHVCMLLAGFGTVFLGPTLPVLAASAHASDSGSGLFFTAQFVGAFFGGVTTSSRLWFSLIRGSAAATFGFALLGACALLHASLLWDAAALLPLGFGVGQMLTAVNLLASQRFATSRGSALSLVNLSWSLGAVCAPFLLGSLLPHVRLGALLVCAAAIFASACLASIVNARGFGPARVAMARGAIRRGLPKVAFVYFGFLLLLYGGVETCIGGWITTFGTRYGSGALQISALGESALWIGITSGRALAPLLLKVMRERTLLISTLLTATALTAMLSRANGAAAITLIAGLLGVALAPWFPLVLSAMLGEGAAAGEVGTIIAVSGIGAATLPLLLGTVSRASGSLRIALLVPLCGLLLLFALSFRRSEPLPATEIQHA
>NC_018014.1|WP_014785247.1|1617904_1618792_+|SCO-family-protein
MGQRCCAASLLCFCGLLAGCRKPTETIAKTTREFKVKGKIVATDPAHSEITLDHEAIPGLMEAMTMPYKVARPEIVEELHPGDVIRARLLADQTSDGDYTNSKLDQIAVIGQAKPDFKPKSNYHAPNPGDVMPDFALTDQDGKSIHTSQFKGKALLITFIYTRCPIDDFCPKMSRNFAAISKSLAADRALYDGTHMLSISFDPAFDKPSVLRAYGKTYTGAAGFAHWQFAAPTAAALPDVEKYFNVGATPESDGSLTHSLSTVLIDPTGKVAAWYPGSEWKPEEVVAKIRSMPRG
>NC_018014.1|WP_157178582.1|1618902_1620786_+|ATP-binding-cassette-domain-containing-protein
MSGGHSTRSMERTARNPSRSISAELTQKKPKPPLKKVWPEVKKLVKPRLPLLGVSLLVLIINRACGLVLPASTKYLIDDVMRQHHAALLPRIVGMVVTATILQGLTTFALTQMLSKAGQRLITEMRTQVQSHIGRLPVAYYDANRSGTLVARIMSDVEGVRNIIGTGLVDFLGGLMTAIFAFIYLIRLSTQMTLLTFGVLVLFGGVMARAFKTIRPIFRARAIINAEVTGRLTESLGGVRVVKGYHAEASEAKVFADGAQRLLKNVISTLTAQSIMALSSTAVMGIVGALVMYLGARQVLAGTLTTGGYVTYTMFLAFMIAPLMSLVNIGTQITEALAGLDRTAEILNEREEDAYPKRTVVLPPIAGDVVFDNVMFEYDPGKPVLHGVSFEARPDTVTALVGSSGSGKSTIISLVCAFHDATTGKVLVDGIDLSTVQLASYRSQLGVVLQETFLFDGTIRDNVVFSRPDATEEQLMEACRIARVDEFVERFELGYDTIVGERGVKLSGGQRQRLSIARAILADPRILILDEATSSLDSESEAMIQQGLNHLMTGRTTFVIAHRLSTIRNADQILVIEGGNIVERGTHTTLFALRGRYRELYDRQHGLESNLFLAPGEGDKLVEPAAV
>NC_018014.1|WP_014785249.1|1620804_1622913_-|oligopeptidase-B
MISPLLAAVAATVQPPTAKQVPHPTHLHGHTLEDDYFWLREKESEEVLAYLSAENDYTDAVMAPTKDLQEKLYREMLSHIKETDTSVPYRDGDWFYLTHTVEGSQYAIHCRRRAAADRSYDASAPEEALLDVNKLAEGKPFMALGALSVSPDGNLLAYTTDETGFRQYTLHVKDLRTGDVLPDTAQRVGSLVWTPDAKTIFYTVEDEQTKRQDRVLRHTLGTAADADVLIFEEKDERFNVGVGRSRDRKYLFLEVGSHTTSEYRFVDAATPTAEFQLLAERVPDQEYYPDHRDGFFYIRANDTGKNFRVVTAPVATPDRDHWTELLPESKDIPLDDFEVFQHFAVASEIVQGLDRMRVFRFENNTLSKDFKTVAFPEPSYSAGLHVNRNFDATTLRYSYQSLVTPASVYEYDVATGESTLLKQQEVPGGFDRELYASERLWATASDGVRVPVSLVYRRDSFKRDGTNPLYVYGYGSYGYALPVGFGTSRLSLLDRGIVMAYAHIRGGGDLGDAWHDDGKMMVKRNTFTDFIEVTEHLIVEKYGAKDEVIIEGGSAGGLLMGAVVNLRPDLFRIVLSHVPFVDVMNTMLDASLPLTVAEYEEWGNPNEAEAFGYMRSYSPYDNLQPGIYPATLVKTSLNDSQVMYWEPAKFVAKLRTLKTNNDAPLLLHTNMDAGHGGASGRYDYLREIAMDYAFVLRELGLA
>NC_018014.1|WP_014785250.1|1623116_1623629_+|DUF4142-domain-containing-protein
MKIRTIALTTALFACTATAAFAQDFSDKDKSFLKDSTQDNMAEVKMAELAIKTTKNPKIRSFAQKMVTDHNALIAGSKPVAAKAGVEPPKTDGFEANADYLKLKILTGETFDKSYVKTMVSDHHSDLDKIKQENAATTNADMKKLTTHAATVVAGHTKMIDTLAGSMGLQ
>NC_018014.1|WP_157178583.1|1623842_1624562_+|TPM-domain-containing-protein
MPQPTAYVNDYAGVLNDSTKSDLDAQLKQLDTQAHAQVFVAIIHKIEDDNSPAEFANQLFAKWKPGAKGSDHGVLLLLSVEDHKYQFEVGYGLEGILPDAKTGDIGREMVPDLKAGSYDGAVRTAVNSLTTVIAQDAGVTLDVPQHTYRRQNVRQKSGVGGIIGFLVVLFIIFLLMRGGGRGGPGGFLTGMLLGNILGGGGFRGGGGGGGFGGGSDDGGGGFGGGGGGSSGGGGAGGSW
>NC_018014.1|WP_041593087.1|1624618_1625188_+|LemA-family-protein
MKKGLIGLIVAVVLIGLVAMSFISAKNSIAVKSNGIDAAFSEVDVNLQRRADLIPNLVASVKGYAKVETNILTAIAEARSGLLQARTPDEKLAANDRLSVSLLPLTRMQEAYPDLKSNQQFMRLEDELSGTENRIAVARKRYNDSILDYNNTIAVFPNSMWASIAGFKPRTTYYRADPGAATVPKVDFN
>NC_018014.1|WP_041592493.1|1625284_1626289_-|polyprenyl-synthetase-family-protein
MSSLPIATAKEVFDLVRDDLSAVEREFGRQSKSEVVVIQDIARYLLSGGGKRIRPLLLLLSAKALGFTGESRIRLGAVVEMLHTATLVHDDIIDEAQTRRGKPSANTAWGASKCVLAGDWLYMQSFQTALDERNFKILDLLIGLTQQMVEGELLQMQKLGHLINEEEYFDLIFRKTAMLFKVSMQLGAALAGVDETVEQQLGEYGRNLGLAFQIVDDVLDLVGEEATLGKPAASDLREGKATLAVIHALERGTGAEREAIRTVLADRDFTRVKHATILEILRGHGSLEYAMDAARAYAEAARQSIADLPQANAEAGRALRALLWVPGYVTDRDR

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Crispr_ID: NC_018014_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_5

1711179-1711271

Orphan

Consensus_repeat	Method
TCCTTTCGAATCTGATTTTTGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018014_5

>merge|NC_018014|5|1711179-1711271|CRISPRCasFinder
TCCTTTCGAATCTGATTTTTGCGTGTAAGTCCTTTGGAATTTGATTTTTGCCGATTTGGGAAAACTCAAGTCCTTTAGAATCTGATTTTTGCG

>NC_018014|5|4|1711179-1711271|CRISPRCasFinder
TCCTTTCGAATCTGATTTTTGCG	TGTAAGTCCTTTGGAATTTGATTTTTGCCGATTTGGGAAAACTCAAG
TCCTTTAGAATCTGATTTTTGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_157178585.1\|1709506_1709929_+\|general-secretion-pathway-protein-GspG	unknown	unknown	gnl\|CDD\|225076
NC_018014.1\|WP_014785317.1\|1704594_1706136_-\|leucyl-aminopeptidase	unknown	unknown	gnl\|CDD\|234863
NC_018014.1\|WP_014785325.1\|1714113_1715901_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|227319
NC_018014.1\|WP_014785321.1\|1709934_1710396_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|130771
NC_018014.1\|WP_014785330.1\|1719995_1721228_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_018014.1\|WP_014785327.1\|1717412_1717784_+\|response-regulator	unknown	unknown	gnl\|CDD\|333815
NC_018014.1\|WP_081490613.1\|1713574_1714090_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|279875
NC_018014.1\|WP_014785329.1\|1718821_1719988_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340848
NC_018014.1\|WP_041592495.1\|1710432_1711080_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235448
NC_018014.1\|WP_014785331.1\|1721284_1722274_-\|polysaccharide-biosynthesis/export-family-protein	unknown	unknown	gnl\|CDD\|132073
NC_018014.1\|WP_014785323.1\|1711322_1711964_-\|ribosome-biogenesis-GTP-binding-protein-YsxC	unknown	unknown	gnl\|CDD\|234770
NC_018014.1\|WP_081490612.1\|1704202_1704619_-\|response-regulator	unknown	unknown	gnl\|CDD\|381118
NC_018014.1\|WP_014785318.1\|1706210_1706738_-\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|376590
NC_018014.1\|WP_014785328.1\|1717932_1718760_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133005
NC_018014.1\|WP_014785315.1\|1702188_1704180_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|223097
NC_018014.1\|WP_014785314.1\|1701093_1702161_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103
NC_018014.1\|WP_014785324.1\|1712088_1713429_-\|DUF1939-domain-containing-protein	unknown	unknown	gnl\|CDD\|236518
NC_018014.1\|WP_157178282.1\|1706927_1709414_+\|type-II-and-III-secretion-system-protein	unknown	unknown	gnl\|CDD\|224367
NC_018014.1\|WP_014785326.1\|1715897_1717238_-\|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NC_018014.1\|WP_014785313.1\|1699733_1700954_+\|aspartyl-protease-family-protein	unknown	unknown	gnl\|CDD\|379408

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_157178585.1\|1709506_1709929_+\|general-secretion-pathway-protein-GspG	gnl\|CDD\|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	9.17151e-10
NC_018014.1\|WP_014785317.1\|1704594_1706136_-\|leucyl-aminopeptidase	gnl\|CDD\|234863	PRK00913, PRK00913, multifunctional aminopeptidase A; Provisional.	0
NC_018014.1\|WP_014785325.1\|1714113_1715901_-\|ABC-transporter-permease-subunit	gnl\|CDD\|227319	COG4986, COG4986, ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism].	1.91391e-121
NC_018014.1\|WP_014785321.1\|1709934_1710396_+\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|130771	TIGR01710, Type_II_secretion_system_protein_G, type II secretion system protein G. This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	2.45234e-14
NC_018014.1\|WP_014785330.1\|1719995_1721228_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	7.07585e-39
NC_018014.1\|WP_014785327.1\|1717412_1717784_+\|response-regulator	gnl\|CDD\|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	4.00199e-21
NC_018014.1\|WP_081490613.1\|1713574_1714090_+\|AI-2E-family-transporter	gnl\|CDD\|279875	pfam01594, AI-2E_transport, AI-2E family transporter. This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA, has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration of AI-2, TqsA affects gene expression in biofilms and biofilm formation. TsqA belongs to the AI-2 exporter (AI-2E) superfamily.	1.21697e-18
NC_018014.1\|WP_014785329.1\|1718821_1719988_-\|glycosyltransferase	gnl\|CDD\|340848	cd03821, GT4_Bme6-like, Brucella melitensis Bme6 and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.	1.96521e-69
NC_018014.1\|WP_041592495.1\|1710432_1711080_+\|hypothetical-protein	gnl\|CDD\|235448	PRK05414, PRK05414, urocanate hydratase; Provisional.	1.86683e-06
NC_018014.1\|WP_014785331.1\|1721284_1722274_-\|polysaccharide-biosynthesis/export-family-protein	gnl\|CDD\|132073	TIGR03028, EpsE, polysaccharide export protein EpsE. Sequences in this family of proteins are members of a polysaccharide export protein family (pfam02563) which includes the wza protein from E.coli. This family of proteins are homologous to the EpsE protein of the methanolan biosynthesis operon of Methylobacillus species strain 12S. The distribution of this protein appears to be restricted to a subset of exopolysaccharide operons containing a syntenic grouping of genes including a variant of the EpsH exosortase protein. Exosortase has been proposed to be involved in the targetting and processing of proteins containing the PEP-CTERM domain to the exopolysaccharide layer.	4.39633e-18
NC_018014.1\|WP_014785323.1\|1711322_1711964_-\|ribosome-biogenesis-GTP-binding-protein-YsxC	gnl\|CDD\|234770	PRK00454, engB, GTP-binding protein YsxC; Reviewed.	1.364e-67
NC_018014.1\|WP_081490612.1\|1704202_1704619_-\|response-regulator	gnl\|CDD\|381118	cd17580, REC_2_DhkD-like, second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains. Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.78273e-23
NC_018014.1\|WP_014785318.1\|1706210_1706738_-\|SsrA-binding-protein-SmpB	gnl\|CDD\|376590	pfam01668, SmpB, SmpB protein.	6.21925e-78
NC_018014.1\|WP_014785328.1\|1717932_1718760_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	3.7186e-58
NC_018014.1\|WP_014785315.1\|1702188_1704180_+\|arginine--tRNA-ligase	gnl\|CDD\|223097	COG0018, ArgS, Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].	1.21513e-108
NC_018014.1\|WP_014785314.1\|1701093_1702161_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	5.45215e-24
NC_018014.1\|WP_014785324.1\|1712088_1713429_-\|DUF1939-domain-containing-protein	gnl\|CDD\|236518	PRK09441, PRK09441, cytoplasmic alpha-amylase; Reviewed.	3.75435e-126
NC_018014.1\|WP_157178282.1\|1706927_1709414_+\|type-II-and-III-secretion-system-protein	gnl\|CDD\|224367	COG1450, PulD, Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion].	3.45948e-43
NC_018014.1\|WP_014785326.1\|1715897_1717238_-\|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	1.2076e-102
NC_018014.1\|WP_014785313.1\|1699733_1700954_+\|aspartyl-protease-family-protein	gnl\|CDD\|379408	pfam13975, gag-asp_proteas, gag-polyprotein putative aspartyl protease. This family of putative aspartyl proteases is found pre-dominantly in retroviral proteins.	5.13387e-12

>NC_018014.1|WP_041592495.1|1710432_1711080_+|hypothetical-protein
MFTALRLHRTVWAGSLVLGLGLNDAGRAFALASLAAGAAALLLEDDPARLREASREGCATFTVTTLDEALRALKNEVRQGRAITVALGGSVEQWLSEMAERGVLPRSLAVARELSDAEAAAIGILKDWGAERLHGLGLIGPGEVELTVGAHWAITTDTATNQAERRSLDAALLAAAEGDAAMSEVTRQWLRAAPTLFPRSLDRSHWQSLSTPVKA
>NC_018014.1|WP_014785321.1|1709934_1710396_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MTTDKTSRRTLDPASTDCGSAAAPHAGQSGFTMLELIVVMMIIGILAAMAVPAFTHHLKVAREAVLREDLHTMRQAIDSYTVDKQKAPQSLDELVTSGYLKSMPLDPMTHRTDTWVGDRSDQYQNVDETATGINDVHSGAQQLSTDGSLYTTW
>NC_018014.1|WP_157178585.1|1709506_1709929_+|general-secretion-pathway-protein-GspG
MVELVVVVSIIAILATAAVPVTRWQVKRTKERELRAALWEMRSAIDHYKDAAERGAFQTKVDSFNYPPDLETLINGVDVKDKKVRFLRRIPIDPMTKGTEWQLRAMQDDADSTSWGGQNVFDVHSKSQGTALDGTKYSEW
>NC_018014.1|WP_157178282.1|1706927_1709414_+|type-II-and-III-secretion-system-protein
MLGKGGESQGQGRSLCHSLPRGLLRSGAAAMVLLSMAAVTIPAGHTQSANAWSKRGADAEVSEDWDAAFEAYRQAHLLKPKDLRYKTHFERARFSAAAAHVDRGRVLRQSGDMRGALTEFERALAIDGGNQAAQQEITVTERLLSDAPTSSLDLPVPVGPTPDMLSISEPLKLKPVSNNPLTLHMVEDTKVLYQAIGKEAGLNVIFDPDYTSRRIALDLNNVSLNDALRILGTQAGTFYKAVTNNTIFVAQNTQTKRTDLASVAVQTFYLSNAATQADQNELLTALRNVLDQNVKIFLVPSQNAIVMRATPDQLLLTQELLNNLDRPHSEVVVDVAVLEVNRDRARNLGVTLPQSFSITPQVANSTTTSSTTGSTTTTGSSTSSTSTSPTLNTLAHLTGANFAVSLGTATVNALLTDNDTRVLQNPRIRATDGQRAQLKIGQRIPIATGSYSSGASTSVVSSLVNTQFQYIDVGVLIDMTPTVHADREITLKMALEISSQNGSVSISGVTQPIIAQRKVEQVIQLKEGEPSILAGILSRSETDSISGTPGLASIPILKNFFRSNNRDRAQDEVVFLLIPHIVREPLVTRMNTRALDTGTGQSIELRHDAVPESVATDTSASLSTGAFQQQRSNAAAANGAPLTAAQAAAAMIGQVGNENSPGSQRAMQALAAGGTPTTAATAAAQAIPGAGGPVSFSITPGQTTQAMGSTFQMAVIANGAKDLYSVPLQVQFNPSLLSLVNVDSGEFLGRDGQSVAIVHRDEGNGMVTISISRPPAVRGMDGQGSVCVLTFRANAPGDSQVSLVKVGAKDSAQTNLPAVGSAATVHVR
>NC_018014.1|WP_014785318.1|1706210_1706738_-|SsrA-binding-protein-SmpB
MPHSPTATQQNPPKKPKERDAVAVGTRDAAYNRQAGHNYFLSDRWECGVALRGTEVKSIREGKANLRDAYGLVKDGEAFLLNAHIGAFSHGNTMNHEETRTRKLLLHKEELRRLTVKTKEKGFTLIPTRLYFKNGRVKCELALAKGKQDWDKRETERKREADKEAKSAIARSQRR
>NC_018014.1|WP_014785317.1|1704594_1706136_-|leucyl-aminopeptidase
MSTQLLFSDAVSFATPLLAVFAVDIAVGTDAPALPTLLTTSDALSDAASAFLTSGEFKAACGETLLLHSPNGLKADRLLIVGLGKVSKLAPTELRIGAGTAVRVAKTKSIRNIAIVFPEDRAISDEHLESLDCMPSARSLVEGALLADFDPDTYRSDRKDRSLESITLLAPDQQKATQDEIRAGHAEGVIFAEAQNFTRSLVNEPGNVLTPTELGRRTAAMCQTAGLSCEVHSTAKLKELGMGAFLGVAQGSAEPPALIVMRYKPAQLAPGGKIVALVGKGITFDTGGISIKPADGMDKMKYDMAGAGAMIGAMQAIAALKPKIEVISVICSAENMPSGTAYKPGDVLTAMSGKTIEIMNTDAEGRLVLADGLHYAKTLGATHLIDAATLTGAVVVALGKVNSGLFSNDEATCDHFHAAAKIAGEHFWRLPCTEDYRELIKSSIADIMNTGRDRWGGSITAAMFLKEFVGDTPWVHLDIAGQAWIDDHHTEIAKGPSGVAVRSIVEWVRALSV
>NC_018014.1|WP_081490612.1|1704202_1704619_-|response-regulator
MGEGAVCMTLAESTILVVDDEPILRLTFSLVLKQTGATVHVAEDGINALDVLERERVDVILSDKQMPQMDGIAMIRTLRERGNTAPVVLFVNGVASESPAEMDRLGVTETVTKPLHPAELVKILARVVEPIPASGKQP
>NC_018014.1|WP_014785315.1|1702188_1704180_+|arginine--tRNA-ligase
MYRTQRQALLTKMEQVLKDKYDITGANIATEQPPTIALGEIATPVAFELAKRLRKAPKMIAAELAAELSGMDGVAAVEVAGAGYLNIKLDRADAARRIAKGEHADVGGKGLRLIEHTSINPNKAAHVGHLRNAILGDTFARLLKKDDYKSGYPVVVQNYIDNTGVQVADVVVALLHLEGKTPEQVDELIGGLIARGERVDYFMWDLYARVSQWYDSDPAEKEARKKLRLDTLHELEEGNNEVSRVADLVATAVLERHLETMERLGIEYDFLPRESEILHGHFWDAARTLMIERGVLYEETAGKNKGCWVMRRPNADAVEEGAIDEDAKVIVRSNGTVTYVGKDIAYHLWKFGLLPGRDFGYKIFREYATHPCWISTMDGEEKHPHYGQATAIYNVIDSRQNDPQANVVESLRAMGYTEAAEHYTHVNYEFVALTPRCAEELGYVLSDEDKQRAYIEVSGRKGFGVKADDLLDRLIAAAKAEVDSRHPEDAEALRQDAAEKIAIGALRYFMLKFTRNTLIAFDFREALSFEGETGPYVQYSAVRAANILRKSGVSHEDAIRGLQGFDLAPYFTGEAGDSLWAMWLIASRVTTVVEQAIAAAEPAIVARYAFQLAQEFNNFYHRNHVLNETDESRKKLLLATAAVGYRELERVLGWLGISVPASM
>NC_018014.1|WP_014785314.1|1701093_1702161_+|flippase-like-domain-containing-protein
MSQNEKVSTARKYWKLIPGFAISAYFLWRVLRDLKVDRLREMRLSHPVWIGVFVAFIVCDYALRGYRWWYMLRPVKASYRACVRVLLTSLAANNILPFRIGDFMRIFAYAPDVNAPSSTVLSTVLLERLLDIFMLFTFFVVELQGADSRFPQHTIYGHSLGVQELAIVLLMVAAVGLGALLFGTRLLQRITHGLVARFGQHPRTKKLGEWASLLFDAVLHLTFVDRIWLVLITSAVWFCESVLFISAAKMVGIESGVRGPWLAASLSNLSFMLPSAPGGIGPFEGSAKLAMQSQGAMADDAALFAVLVHVLIWFAITAVGGIGFLVHRAARGAMSKPLTEELAAVPVDLEVPETH
>NC_018014.1|WP_014785313.1|1699733_1700954_+|aspartyl-protease-family-protein
MRLIPLIALQVILVMVHGLQAQSPEALKAAYDAKHVFALRDAVAHSSAPRLYKGAVDASANRVQTATKELQAVIQHDPHSDEAYEAHDLLGNLYFRNGMYREGYGEIVAALRESPNASDAKSMLSIFTALNELPKMSVVEMKPTSMAIEPGSLSLPFQANGKDLKFFFDTGAAISIMGESEAKELGILAKPVEGKMNDSSGRGVSGLRVALVSDLRIGGLHLRNVPFLVIADSGEPWTHAPKNERGIIGLPLLIAMRTFRWTPEGRFEFGLPAGKPDINTCNMLFHNSSPVVDVLVEGMHLDFTLDTGAVDTDLNPPFAKALPDLMKSGQPEERALEGLGGKVVNASLLLPSVTFAFGGKSLALSPAHVFTEHGNGAWAPGNLGMDLLRQARAFTVDFEAMTLRLE
>NC_018014.1|WP_014785323.1|1711322_1711964_-|ribosome-biogenesis-GTP-binding-protein-YsxC
MRLRAQFLLSAFAPEHFPSTVKTGGVPEIAFLGRSNVGKSSLINALLGEGQARVSSTPGRTRSINFFAMHEVLNSGTMRPNPALILADLPGYGYAKISKSISAEWSSFVDPYLADRETLALSCCLVDTNIPPQESDAQMIKYMQLHRQPFVVVGTKSDRLSNNTLANSIATLKREHGVGEIIAVAAKEGKNGRGMKELWARIEAARVGTETEG
>NC_018014.1|WP_014785324.1|1712088_1713429_-|DUF1939-domain-containing-protein
MAVMMQGFYWDCAKEEDKLGEWWNFVAGEIPKLGKKGVGFDSIWLPPISKGADKGTMGYDPYDYFDLGDFEQKGQLKTSFGNRAELEKLIGIIHENGMGAIADMVINHNSGADAEEENPLDGEKRWTKFTPASGKFARNWDCFHPSRYEKVMMEGEQFAGFPHLCHRNPKVYGAMYDYARMIIEDLDFDGFRFDFVKGFGAWMIGLLAKYEYQKKNNPNFSPFVVGEYWSGPEDIGDWLDSVSKLTDSQIAAFDFPLRYKLKDVCDTPNYDLRNLTDGNSVSAARPFNAVTFTENHDMGGNEVVNDKMLGYSFILTQDGYPCVFWKDYYNFGLARPNSPNGIDALVSAHHKHAGGESCILHADPDLYISQRGGNEGQSGLIYVLNNLGNQWSGTTVQTKWPNTRFVPVAWDGKDEAHPDERSTDAEGKGEFPAPPRGYCVYAPVFE
>NC_018014.1|WP_081490613.1|1713574_1714090_+|AI-2E-family-transporter
MNDVRTTLERTNNSGISTSPSGGDPFRTAGGAIAGWWRATTLDALCVGLMWFVGLYFIHVPWAPLWALVAAFCQFVPGIGMAIAVCGPAVSAALASSDTDFDKLWWTLGLYAFIAIVDGLIVQPMLLKRTTLVPWWAAMLGPIVGGILLPPWGALIAPPVLAVIFAFRKKR
>NC_018014.1|WP_014785325.1|1714113_1715901_-|ABC-transporter-permease-subunit
MKNLPDSFGSLRTRRELGIPQTLARSQAVQRSWPFFLDLIVACIGLAAFYGVVQIARLWLGQPQPNVVLSLSPQALPRYAFYSVVRMGLAYILSLLFAVGYGYVAAYSRRLEALMIAALDILQSIPVLSFLPGVMLAMVALFRTRQIGLELGCIVLIFTGQVWNMAFSFYSSLKSLPRELTEASAIYGFSRWQRLLQLELPYAAIGLIWNSMVSVAGGWFFLMACEMFVLGSRDFRLPGLGSYLQTAASEGNTKAIFWGLMTMILIIVATDQLLWRPIIAWSDRFKFEQVESSRRVRSPLLSMLQQSNFVRRLGRVTFEPLTEKLYRHEAKRRSTHPQYDEASRRAPSTFFRMAGLALILIVVGYAAVQALHLLRSVDRHEVLQIFGGAGMTLMRVVIALVLATLWTVPAGVAIGFHPRLARIAQPLAQIAASVPATALFPVLLLLLFKTGAGMGTAAVLLMLLGTQWYVLFNVIAGAMAIPNDLKEVARLFRFSTVQRWRTVILPGIFPYLLTGLITASGGAWNASIIAEYFRLKSNTLTTFGLGEQISAATDAGRFAVLLLATIVMALMVVTINRLIWRPLFRIAESKYKLGA
>NC_018014.1|WP_014785326.1|1715897_1717238_-|nitrate/sulfonate/bicarbonate-ABC-transporter-ATP-binding-protein
MQQAIIRAERVEKYYAQPSENRIQVISPTDLSIVPGEIVALLGPSGSGKSTLMRMLTGLSIPSAGQVYWHEKPIAQADINVAIVFQSFALFPWLTVLENVEAPLQARGMEPVERRKRALKMLDTVGLDGFQHAYPKELSGGMRQRVGFARALVVEPEVLFMDEPFSALDVLTAENLRSELLELWQKKTMPTQAIFIVTHNIEEAVLLADRIIVLGRNPGHVRVDFRVALQHPRDRKASAFTQLVDYIYKVLTQPEAQPPALPRTADGKRVRDQRLMSYQMLPHARPGGIAGLLELMVDHGGKADIYRLADDLAFEVDDLLPIVDASSLLGFLQITEGDAALTSIGSEFANAEILRQKEIFRAAAVENVLLLRQIVRALEAKSDGTVPEEFFHDMLDEQFSEEETLRQLETAINWGRYAELFDFDAQRRRFTLAHNQAAESAAEVSG
>NC_018014.1|WP_014785327.1|1717412_1717784_+|response-regulator
MTNTSTKPRVLVADDEQVIANTLAIILNQAGFEARAVYSGENAVESLDEFQPNMLISDVIMTGMTGIEAAIKVRAKLPNCKILLFSGQAATADLLEKARAQGHEFEILAKPVHPTDLLAKLRS
>NC_018014.1|WP_014785328.1|1717932_1718760_-|glycosyltransferase-family-2-protein
MISVVILTKNESTDIGGAIRSVSFSNDVHVFDSMSTDGTQEIARSLGATVHERVFDNYAAQRNASLTQPAFRHDWVLILDADERPTRELVAEMQRAVATADADVDGFRLRRHDYLWGTWLEHAQITPYYTRLVRRGRARYVREINELLEVDGRIVELQAPLNHYPFSKGIAHWVAKHNVYSTMEAQLLASGAATADASLQVALFGKDRGERRAAQKALFFKLPMRPVFKWIYMMFIRGAVLDGYAGLTYSTLQSFYEYLIELKRREIMHERLLNI
>NC_018014.1|WP_014785329.1|1718821_1719988_-|glycosyltransferase
MRILHVIPTLNPAMGGPIEGVRTLFTYVNEGYIGEAVTADLPDAPWLQGLAFPVHALGPSTGGTYGYNARLLPWLRANIDRFDGVIVNGLWQYNGLPAMLAARGRKPYMVFTHGMLDPYFKRRYPLKHLKKVLYWYPFEYWVLRRAYRVLFTTETEERLAQESFAAWRWRPQVVPYGIRAPQSRPEDDISTFLEHVPAVRGKRFLIYLSRIHPKKGCDLLLQAFSEVSASDPDLHLVMAGPDETGWIPELKAVAEKAGCGHRVHWPGILRGPAKWGAFRAAEAFILPSHQENFGIAVAEALAAGLPVLLSDKVNIGDMLVGEGCSLIQPDTLDGTRHLLESWIAMHPSDRQAMSEHAAECFRSRFDMLETAQVIMSLFRQAQLEGGKR
>NC_018014.1|WP_014785330.1|1719995_1721228_-|glycosyltransferase-family-4-protein
MEGVHRRIRLAYVVSHPIQYQAKLLRLIAADPGIDLTVFFCSDLSLRSYKDPGFGVSVTWDVPLTEGYRSVVLPRWRDTNKLSPTRPIARGIFRGLLRGIDGEPFDALWVHGYSTVNSLHAMLAAKALGIPVLLRAESWLADRTRSHTTLLIKQLYFDGLKMLVDAVLPIGSRNATYWTHYFGADFPAFTMPYAVDNEYFATRAEAATRNRAELQTEFNLDPSRPVILFASKLQERKHADHLLEAYLQLRVQTSLDPYLLIVGDGETRAQLEQRASASGVEGIRFLGFRNQSELPRFFDLSTVFVLPSRHEAWGLITNEAMAAGLPVIVSDDVGCAVDLVRNGENGYVYPLGDIAALRNALAATLAPGRRESMGERGREILSRWSYREDLVALKAALQRVTKLPIQKISG
>NC_018014.1|WP_014785331.1|1721284_1722274_-|polysaccharide-biosynthesis/export-family-protein
MSLTRMLRLIQTAALTLTTCVALCLPAAAQYTGTVPTSAPGLNVRLPITTDPAVLYPPQRELTLLPGDLLKISVYGVAPEYTDTERVDLDGSIRMNLGGVIHVAGMSVKEAEVAMSERFESAEIFHSAQVSIELTEAPQHFATVVGEVKGTVPILGPKRLLEVMAANGGIPATASTVLRIDRLGQAEPIIVDIGNDPARTVQANVPIFTGDVITVGRVGQYYVLGAVMRPGVGQLSGSIPVTAVEAVSAAGGLTFPAKGDQATLIRNVGGQRTVINLQLRQIQDGKLADVVLQSDDILLVPSSGLKKFLATQSSGTVVALIVAMATLLR

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Crispr_ID: NC_018014_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_6

2133077-2133170

Orphan

Consensus_repeat	Method
CTGGGTACAGCACAAGCGATGTCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018014_6

>merge|NC_018014|6|2133077-2133170|CRISPRCasFinder
CTGGGTACAGCACAAGCGATGTCCCTTGGCGGGCAGAAGGCCCGCGACTTCCCAGCCCAGGGCAACGCCCTGGGTACAGTACAAGCGATGTCCC

>NC_018014|6|5|2133077-2133170|CRISPRCasFinder
CTGGGTACAGCACAAGCGATGTCCC	TTGGCGGGCAGAAGGCCCGCGACTTCCCAGCCCAGGGCAACGCC
CTGGGTACAGTACAAGCGATGTCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_041592523.1\|2139496_2140291_-\|TIGR00282-family-metallophosphoesterase	unknown	unknown	gnl\|CDD\|379099
NC_018014.1\|WP_014785657.1\|2131426_2132752_+\|L-fucose:H+-symporter-permease	unknown	unknown	gnl\|CDD\|340952
NC_018014.1\|WP_157178299.1\|2121070_2123116_-\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NC_018014.1\|WP_014785663.1\|2140879_2141464_-\|YkgJ-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|308985
NC_018014.1\|WP_014785667.1\|2145912_2146170_-\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|239274
NC_018014.1\|WP_014785659.1\|2133400_2137273_-\|chromosome-segregation-protein-SMC	unknown	unknown	gnl\|CDD\|274008
NC_018014.1\|WP_014785655.1\|2129748_2130351_-\|CvpA-family-protein	unknown	unknown	gnl\|CDD\|367140
NC_018014.1\|WP_157178300.1\|2142941_2144120_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_018014.1\|WP_014785664.1\|2141556_2142876_-\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|176464
NC_018014.1\|WP_014785651.1\|2123747_2125019_+\|enterochelin-esterase-like-enzyme	unknown	unknown	gnl\|CDD\|225256
NC_018014.1\|WP_014785660.1\|2137729_2139064_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014785661.1\|2139136_2139493_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014785666.1\|2144116_2145853_+\|chloride-channel-protein	unknown	unknown	gnl\|CDD\|238233
NC_018014.1\|WP_157178608.1\|2118285_2119476_-\|esterase	unknown	unknown	gnl\|CDD\|199888
NC_018014.1\|WP_014785654.1\|2129446_2129737_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|225114
NC_018014.1\|WP_014785653.1\|2127527_2129411_-\|Flp-pilus-assembly-protein,-secretin-CpaC	unknown	unknown	gnl\|CDD\|333965
NC_018014.1\|WP_014785668.1\|2146193_2146970_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|187616
NC_018014.1\|WP_014785656.1\|2130356_2131250_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NC_018014.1\|WP_041592521.1\|2119589_2121074_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014785652.1\|2125008_2126988_+\|carbohydrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|226064

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_041592523.1\|2139496_2140291_-\|TIGR00282-family-metallophosphoesterase	gnl\|CDD\|379099	pfam13277, YmdB, YmdB-like protein. This family of putative phosphoesterases contains the B. subtilis protein YmdB.	9.91531e-148
NC_018014.1\|WP_014785657.1\|2131426_2132752_+\|L-fucose:H+-symporter-permease	gnl\|CDD\|340952	cd17394, MFS_FucP_like, Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.04969e-131
NC_018014.1\|WP_157178299.1\|2121070_2123116_-\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	9.64087e-19
NC_018014.1\|WP_014785663.1\|2140879_2141464_-\|YkgJ-family-cysteine-cluster-protein	gnl\|CDD\|308985	pfam03692, CxxCxxCC, Putative zinc- or iron-chelating domain. This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex. However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.	0.0035938
NC_018014.1\|WP_014785659.1\|2133400_2137273_-\|chromosome-segregation-protein-SMC	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0
NC_018014.1\|WP_014785655.1\|2129748_2130351_-\|CvpA-family-protein	gnl\|CDD\|367140	pfam02674, Colicin_V, Colicin V production protein. Colicin V production protein is required in E. Coli for colicin V production from plasmid pColV-K30. This protein is coded for in the purF operon.	2.61329e-23
NC_018014.1\|WP_157178300.1\|2142941_2144120_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	3.73069e-09
NC_018014.1\|WP_014785664.1\|2141556_2142876_-\|adenylosuccinate-lyase	gnl\|CDD\|176464	cd01360, Adenylsuccinate_lyase_1, Adenylsuccinate lyase (ASL)_subgroup 1. This subgroup contains bacterial and archeal proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP).	0
NC_018014.1\|WP_014785651.1\|2123747_2125019_+\|enterochelin-esterase-like-enzyme	gnl\|CDD\|225256	COG2382, Fes, Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism].	4.58341e-23
NC_018014.1\|WP_014785666.1\|2144116_2145853_+\|chloride-channel-protein	gnl\|CDD\|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	3.06971e-101
NC_018014.1\|WP_157178608.1\|2118285_2119476_-\|esterase	gnl\|CDD\|199888	cd02858, E_set_Esterase_N, N-terminal Early set domain associated with the catalytic domain of esterase. E or "early" set domains are associated with the catalytic domain of esterase at the N-terminal end. Esterases catalyze the hydrolysis of organic esters to release an alcohol or thiol and acid. The term esterase can be applied to enzymes that hydrolyze carboxylate, phosphate and sulphate esters, but is more often restricted to the first class of substrate. The N-terminal domain of esterase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase, among others.	1.35115e-32
NC_018014.1\|WP_014785654.1\|2129446_2129737_-\|histidine-kinase	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.29549e-06
NC_018014.1\|WP_014785653.1\|2127527_2129411_-\|Flp-pilus-assembly-protein,-secretin-CpaC	gnl\|CDD\|333965	pfam00263, Secretin, Bacterial type II and III secretion system protein.	1.65767e-18
NC_018014.1\|WP_014785668.1\|2146193_2146970_-\|glucose-1-dehydrogenase	gnl\|CDD\|187616	cd05358, GlcDH_SDR_c, glucose 1 dehydrogenase (GlcDH), classical (c) SDRs. GlcDH, is a tetrameric member of the SDR family, it catalyzes the NAD(P)-dependent oxidation of beta-D-glucose to D-glucono-delta-lactone. GlcDH has a typical NAD-binding site glycine-rich pattern as well as the canonical active site tetrad (YXXXK motif plus upstream Ser and Asn). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	6.96535e-99
NC_018014.1\|WP_014785656.1\|2130356_2131250_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	9.88857e-179
NC_018014.1\|WP_014785667.1\|2145912_2146170_-\|glutaredoxin-family-protein	gnl\|CDD\|239274	cd02976, NrdH, NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase activity that is dependent on TRX reductase, not glutathione (GSH). It is part of the NrdHIEF operon, where NrdEF codes for class Ib ribonucleotide reductase (RNR-Ib), an efficient enzyme at low oxygen levels. Under these conditions when GSH is mostly conjugated to spermidine, NrdH can still function and act as a hydrogen donor for RNR-Ib. It has been suggested that the NrdHEF system may be the oldest RNR reducing system, capable of functioning in a microaerophilic environment, where GSH was not yet available. NrdH from Corynebacterium ammoniagenes can form domain-swapped dimers, although it is unknown if this happens in vivo. Domain-swapped dimerization, which results in the blocking of the TRX reductase binding site, could be a mechanism for regulating the oxidation state of the protein.	6.05107e-17
NC_018014.1\|WP_014785652.1\|2125008_2126988_+\|carbohydrate-binding-domain-containing-protein	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	1.59001e-47

>NC_018014.1|WP_014785657.1|2131426_2132752_+|L-fucose:H+-symporter-permease
MHGPPVATTRHAVHEAPDLNTPLFSPSHRTAFFVVTALFFLWALPNNLNDVLIRQFMKAFQLSRLQGGLVQSAFYFGYFCISMPAAYVLRRWGYRVGLVTGVLLYGVGCLLFWPAALANQYSFFLIALFVIAAGLAFLETGGASFITLLGDPSTSERRLNFAQAFNPPGTIAGALIGTVFIFSGIEPSATETAQMKAAGTYAAFLHRETLRVTTPYLVLALVVFLFAILLMRVKFPARTLSQDQFPFEERGTTASLIHVPHFVWAVISQFFYVGAQVASWSFLIQYAHDYAHQPEKIAGYFLSGSLAIFSVGRFAATALMKYVRPNVLMGIFALINVALLVLVILFPGWVGLWALMFTSFFMSLMYPTNFALGLKGLGANTTLGASVLVMAIIGGAVATPVVGWVAEQTGSMAMSFIVPLLCYLVVAYFAFIGSKVRTQVS
>NC_018014.1|WP_014785656.1|2130356_2131250_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MILGDLKPILTGKVRDLYEVGTDRLLFVASDRISAFDHVLGSLVPDKGKVLTQLSLFWFDYLRNLVPNHLITADVRDYPADLQVYSDALRGRSMIVQRARMVQVECVARGYLSGSGWKDYQQTGAVCGIALPSGLRESDRLPEPIFTPAAKNHTGHDENVGFDHVVDAVGPELAERLRSLTLAIYGAASKYAESKGLILADTKFEFGFVPSKDGGDLLVLADEVLTPDSSRYWLASGYAPGGAQPSFDKQFVRDYLERIQWNKQLPAPALPDEVVEETRAKYLQAFTLLTGKQELPE
>NC_018014.1|WP_014785655.1|2129748_2130351_-|CvpA-family-protein
MNNTLHGVTIGLNGMNPLDWTIALVLAISVVTAFMRGLIRSVVSLAGLLAGILAACWYAPKGAAYLARWVTPFAFAEIVAFVLILAGVYVLAALLGRVLSGAAGAVGLGFLDRLGGACFGFVRGVLLLASLVLPFGPFLHDFRAAKDSVLLPYLLPAAHGISFVVPRDFGKRLPASDWWNHARSAAGELAPIGKRTTPSD
>NC_018014.1|WP_014785654.1|2129446_2129737_-|histidine-kinase
MKRELDILVAQMHADGISYEEAVREFKRRYLLQVLVNHRGNQCKSAEELGMHRNTLSRTLAELDMDTAQIRSGLKRPARSDRAAGTPRLQTIARVR
>NC_018014.1|WP_014785653.1|2127527_2129411_-|Flp-pilus-assembly-protein,-secretin-CpaC
MTASLPHRRGVSLGCIAALLLSPLAQAQTAAPTPKPLTPLSAKQRARAEDAYLSGAKHLSKAEFLPAEKDFARAIVVDPSRPEYVQALVLSREHRVTNLLQQAAATRPRDAAAADALVGQARALDRDNPRVTQHDGPTAIKPVRKMEVVGGVVLLHTNTRHSYHERSDIRTLASHIAADYGLKAVLDTEVPTKSYRIDVDDASYDEVMSVFSVLTNMMSVPLDEHTLLFAMDTVANRQRYERLVEAVYYLPAFTADQLKDFVSIAQNVLTLKQVSVKPGDGSLVVRGPADLVDAADKIFADLMTGGSDVVIDMKLYAIEKSRTQNLGVVLPSSLNAFSLASQAQSIVSANQSLITQLIASGVIPSTTSVYELAAYLVFVAGVGGTSSLLSNSFLIFGGGATTGVLSAGNIPTINLALNQSDARSLEDVQLRGSDRQTIIFKAGTRYPIQTSLFSDIASNASSALGNTTVNGVSLSSLLSQYLGTNSSGSNGIIPQFQYEDLGLVITAVPRILRTGDVSMHLEIKVSALSGAALNGIPILSSRQFSSDLTMADGDTALMVSDTTQNETTAVTGVPGLSELPGFQGGTNRNGTRSTGDLVLMLTPHIVRLGHRSPTGPYIALPPRPDDE
>NC_018014.1|WP_014785652.1|2125008_2126988_+|carbohydrate-binding-domain-containing-protein
MNRRHFVLSTIAATAALPIRATPWLSVADAETLEPGVAVLLVDTDRKTAPIDRNIYGQFLEHINHSVEDGLYAEQIQGAGFEGDDFKTYWKPSSEKGHVELIDLEFQNGKKSVRLTAQGGHASIRQGRIFLEQGSRYEGSLWVKRERGSSHLTLRVLGHAGEQIASLPIAVTGSEWKELPFSFTSTVRDTQASIELTASGNGSILVDFISMMSAAARANGMFRHDLYSAFNDLKPAFIRWPGGSFASTYRWKEGIGRYAARGYHPNTYWGGYSDYFGFGTDEFLSLCKKLKAEPLITLPATSTKPEDVQYAIDWIHYVNDPPTTEMGKLRAANGHPEPYNVKLFQIDNEPMNNGFTPDAYAEIVNVYGPRIRAAAPSAKVVACGQKRSNDMEWSEKVIDLAGKNFDVLGCHNYEYEPDNFETGVRRIHEYLVKLRDHVHNSDHPKIEIAVLEWSLQHTYDWRAGLHAAGSLMMYESLSPALSMTCPALLMRNITDDPTWTSSIYHDHVSWFPGGSYPVEKLFSDCYAERFLASTSGTFRDQPNRAILFDKISTAIPKGWIPGSVDAVATASEDNRRMVIKAVNYRGVKADLLVRLQGARTPKNATAVLHTITAAPTAAASIENPNAILTETKSFPYTSEFTINLAPYTVAVLEITGSAA
>NC_018014.1|WP_014785651.1|2123747_2125019_+|enterochelin-esterase-like-enzyme
MVLRTTALCFACLALTTGTQAQTPTPPVTTAAPAVRPSGRPAPLVSPQLAPDNRVTLRIYAPQASAVTLAGDMGQGVARDPASNGTTAQALAAAIPMIKTPDGVWTGSSALPIKSGAWRYHFLVDGASVVDSRNVNTSPYQSQMESLLIVPGDFSDTRNVPHGSVSRVKYMASTYQGATREMYVYTPPGYEKGSGTYPVLYLIHGGGETAASWSTVGRANDILDNLIAEGKAVPMIIVMPSGWTPLGGQVMTSDATKDPFNDEMMKDIIPYMQTHFRAKTSPNDRALSGLSMGGIQTLNVGLHNLGSFRYLAVMSSGWTTDQDRQAFFTTEAARIPTYNSQLKLFWWGWGATDIARPNSLLVTDRFKAKGVHMETMETADGHEWKNWRLYLHEVAPKLFQPSKPNEQVSARRGTAQKGIRIEP
>NC_018014.1|WP_157178299.1|2121070_2123116_-|carboxypeptidase-regulatory-like-domain-containing-protein
MATSAYGQTSGSISGHVADPQGAAVPVTSILLKNVDTGAERTTVTTSTGDYTFTEVPIGSYVVSAQHAGFKTSSSSALDVQIGQSVRLDVHLEIGAISETVEVSTAGTLLQSENAATGTVIGNEELTELPLNGRNYLGLVALSSNVNTLSQASGQAGSRLGGDRANQSIAVGGQRIMFNYFTLDGVNNTDPDFNTYIGLPSPDAIQEMKVQTGVYSAEFGHEASQVNVVTKGGTNKYHGTAYEFIRNNFVDARPYWFPQRQAAGAVQQINPFKYNDFGFELDGPIRIPKLYNGKDKFFFMVSKEWFRSRSSNPNATATVPTAAMAGGDFRGYSYQYVDPSGAVRNAPVTIYDPSTGNANGTGRQPFPNNIIPAGRISKQTTALLKYLGTAASLPTYNCPAKVTTNTNCAAVPNYRYSTTSPSNRESLYVRGDYNWSDRTQISFRYGQGDGDSLNTGLLGAGSKTITQYQQYMGSLTHTFSPTVVNETRFGYSNFFNSLGLVSAFTTDVVSSLGIPGLTGGDPATWGIPSVSFSNFAVSGVQSSGAFGTAPAIWTGFGDQGGDGPYVLRDPSWQIVDNVTLIRGKHSLRLGYEFNRQTFNQLGNQFSRGQFSAQPLTTSFYTGTTLTGGDSLADLLLGNLQQSVVAVAVANANDVRNVQAGYVDDTFKGARSSPHPLACDTS
>NC_018014.1|WP_041592521.1|2119589_2121074_-|hypothetical-protein
MTPPWTNTFGNNFNVRLPQLPKQGDTNTTYTAAQLPYYVRQGNCAPADVYASIAVRWTASRAECSNGQIPNDTLMNTRYTDIAPRIGLSWAPMEKTVIRAGFGIFYTQDVANAVFDISRNIAGRVTVTNQNANQLGAPSNLTWANAAPGASGATTVNLPATTVAFSNAVSHKTSYTQQFLLNIQQQIGKNWSMEAGFQGALSRHLYGFINANAATPWSFFGSTSATPVGPRQPFPNVAGGLQYVHDGGSANYNSATFKLNRRFSKGMSLTSSYTYSKSLDNTSGIRNQGNDQLYPQNSYCLSCEYGPSAFDVRNRVVVAALYELPIGPGRLIPLQNKALVSILAGWQVGGIFTHQTGQVATPQTGADNAGISSPFGNFDRPNQTGVSQYLSGTARSVDKWANLAAYAKSPAGTFGNVSRGSFTGPGVTNLDASLHKDFAMPYGEHHALSIRFEAFNALNHPNWNTPTLTINSSTFGQVTAGNMRQLQLAAKYLF
>NC_018014.1|WP_157178608.1|2118285_2119476_-|esterase
MFAAAALTAGTAWAQPPAACKPSSLNIPGAPYPCVMPDRTAMFRVNAPAAQKVQVSAGGRVDMTKKEDGLWYATTPPLVEGFHYYTINIDGASVSDPATRTYFGGGLWSSAIEVPAADAEFYAHKDVPHGVVREQEYFSTVTQQWRRAMVYTPPGYDANAKVRYPVLYLLHGWGENEVGWTYQGHVDQIMDNLIATNKAKPMVIVMDNLNAAKPGEDASIYNARSVLTQAVPVPPPAPGATPAPRGMPRMSNTFTEMMVADLIPMVEKNYRTAPGRENRAMAGLSMGGFQTLNTGLTNLDKFAYLAGFSGNCGSLGASFDPKTSCSGAFADPAAFNKKVKLLYISTGSVEGPRVKQFSDALQTAGVNNVYFESPGTAHEWLTWRRSFQDFAPRLFR
>NC_018014.1|WP_014785659.1|2133400_2137273_-|chromosome-segregation-protein-SMC
MLKLKRVQILGFKSFCDRTDVQLSGNGIAAIVGPNGCGKSNISDAITWVLGEQSAKSLRGVKMEDVIFAGTRDRKPTGMAEVSLTLVDPDVYDASDAGETINMGSVTPKPAEINDWDETAERNMSAEATLAAVAEAQPGPIPADEESEEIEVDAPVDSTAELAAAEAGTVAPNPLVLKIRRRKFNRAPVRAGEITVTRRLFRSGESEYLLNGKICRLRDIQDIFFGTGLSGENYAIIGQERIGQLLSSKPLDRRSIIEEAAGITRFKTKKRLAELRLEAAKQNLARVDDIFDEVTRQMGSLKRQAAKAERYGQMRDELRAKLRVVLRSRLSQHDADRAASEASVTKLTASIDEQAGSLEALDAEHTAGVARGYELDEETRAAQSRINETRIELERATARIHSNTDRVTDLAARIASGTEELAQLKHQIEALSADRDGLRLFLETATADTEEAKQTAQTKQREANEAQAQVNNTDREAGNGRHQSMQLMQRISNVHREEAQAAESLAGLEREAERLIGESEQAKVELEALGKQRGQVSMTFESVTDRLKRLEAEIAQLRLDLDAKRREEMETRRRGDHLRAEAATLTGRKNSLEALIRDHSYSSETVRKLFKANGIATSVAPVGTLADFLEVDDEHGAVVDEFLKEELNYIVVKDWNSADAGIGLLKGNVDGRATFLVHSESAPKYGDGMASRSAGDLRGARPLKDCIRVLNGFGRSLEVILPKLREGFIAPDSETARTLAIENPEAFFLSPSGETFHNMTVTGGKARSGGPLALKSELREIQTKLEGVQAELAQSEIGVAALAKQIQEMQHAVEAKGNERREAEREAANSGAALRQMDSEAARIEKRLADWSLHSERNRDARAQKQDLIERKQAEASQLMMEREAIDVRVSDTLLRIEDLRRQREEVQAAAAAASAALAGLEERRRNASSNFEQNERMRNTTQQRILHLEGQNASAAAERTRREEETVQLIEQQAELTAQREQLSAEAQRLGAEATALRASIGEKNGLLRSLRTEIEGLREQRGTLQTTIARLSSEIEHLEAQSLNDLNMPAEELRADTTIEPITAEALDAADEETRTLKGKLEAMGPVNMMALEEFAEAEQRHSFLETQRKDLLDSISNTQGAIKEIDEISKIKFDDAFAIINKNFSETFVKLFGGGQATMKLTDESNSAESGIDLVASPPGKKMQNVLLLSGGEKALTALSLLVGIFEFQPSPFCVLDEVDAPLDETNVGRFARLIHEMSKDTQFVVITHHKRTMTEADVIYGVTMQEPGVSKIVSVNLNKAETRRVA
>NC_018014.1|WP_014785660.1|2137729_2139064_+|hypothetical-protein
MKKAFLASMLAAACVSATYAVAQTPVNTNNGAAAQGPQLSADEYTAYQAVITATDPAAKATAAEAFLTKFPQSSVKSTVLEQLVAGYAGSNNVPKTLESADKLLQVDPNNIRALALETSLLKAQGDSATDPAAKQSAYDKAADAASRGLKATKPAAVADADWAAIQKQVTPYFYSAIGIDALTKKDSAGAIAAYTSELKAVDVAATTQPGPVLQDTYFLGQAYYTSTPPDYLNCTYFATRTAIYAPEQFKSTFQPLATYCYKKFHGAEDGYDAVKAVAKDNLFPPADFATSVKPAPTPADQATTVFEADKKEDPTLTKTNIADREFVITNGTTEQAEAEFAPIKDKEVKLTGKVVSIADTTLTLAVSDDAKQANPLVADVSVTLTEAPKVAPVVGADVTVVGSMASYTQKPMMFTMTGGTIEGKAAAKAPAKAAPARRAPARKR
>NC_018014.1|WP_014785661.1|2139136_2139493_+|hypothetical-protein
MLPSNRITNALLAVIAVALTAIAARPYVQPTPVAAQSSTFASQAGNADPIYVEPGVYMLRRPEGGQVLGKVTINLRTGNVWGFPTGTPDPYPVTPLDSKPQISHAIPLGRFAVGEADR
>NC_018014.1|WP_041592523.1|2139496_2140291_-|TIGR00282-family-metallophosphoesterase
MNILFVGDIFGSAGRRIVAEHIGHVLESNAIDLCVINGENAAGGFGITPSIADDIFDLGADVITTGNHFWDKKELLDYLKVPADSHGRPRRILRPANFAPKTPGFGVYESALPTGQPYAVVNLQGRVFMQQNDDPFRKADEMLASIKAKVILVDFHAEASSEKVAMGWYLDGRVTAVLGTHTHIPTADERVLPGGTAFQTDVGMSGPYDSVIGVEKEAVIERFLTGQPAKFEAAKGNPKMCAAVIECDGATGRAYRIKRVMLGE
>NC_018014.1|WP_014785663.1|2140879_2141464_-|YkgJ-family-cysteine-cluster-protein
MLPQGDRELVQIMDAALADAAVRSGHWLACRPGCNQCCSGVFRIGPLDAERLREGLRLLGDEKAGLIRDRVRESVARLSPGFPGDTDTGLLFEDDDSLERFEDFADDEVCPVLDPVTGTCDLYAHRPMTCRTFGPPVRTGDEGFGVCELCFVGAPEEAVAAAELHLPDPDLEARLDFETGLSGTTVVAFALLGV
>NC_018014.1|WP_014785664.1|2141556_2142876_-|adenylosuccinate-lyase
MIDRYTRPAMRTLWSDESKFRAWLEVEATASEVLADAGIVPQDAAKAIRTRGDFDIARILEIEQQTRHDVIAFTTAVAEKVGPEARWLHFGLTSTDVVDTAQALLLREASSIIREGLVALSVVLKRRAIEFALTPCIGRTHGVHAEPTTFGLKLLLWYTECQRNIVRFDAAAAGMNVGKLSGAVGSYGTVTPALEEEICTRLGLDTALVSTQVLQRDRHAAYIGALSVMASSLDRIATEVRHLQRTEVREAEEFFSEKQKGSSAMPHKRNPITCENICGLARVMRANSQVALEDVALWHERDISHSSAERVILPDTTTLADYMLSKTTNLIDKLMVYPERMLKNLNLTGGLVFSGQLLLDLAEAGMSREDAYKTVQTLAMKAWKEDLVFKELVAADAQITALLAPERIVRAFDVNRRLENVPAIFERVFGKPLSELQGK
>NC_018014.1|WP_157178300.1|2142941_2144120_+|tetratricopeptide-repeat-protein
MEAGSKQAAAPLPPTPAQASRRRLMIRDGLKFLTLTLVAVVLSGVTTFLFRSFESRRERLAERWAQRGHDAMQRGQSEQAVAALRVSLSYHPDDYENQLALAEALAAGGHVDEAENYYLNLWQSRPGDGPINLQLARLERTRGRDQQAIDYYRAAVFGTWAGDAPARRRDTRLELSRYLVDRGQPLAAQAELLIAAGNNPDPATQLRIAEALEAAGDTSSALTAYRRAEVGSQLHTAQARAGELCFRAGDYTCAEDSLEKALRSKTWTAEQITRLNGMHDDAARLQELAFSPVVPPALRSAHLLSDSVIALNRFKTCTDPSLMPLQTRWKALNTPQNRAALRHDDDVQLQYANLIFETEITAAKTCGTPIGDDALLLHLQDHPMTRIGAQQG
>NC_018014.1|WP_014785666.1|2144116_2145853_+|chloride-channel-protein
MSTLISNEKETSTDSSPMREERLFLLLSIFIGIISGLVVVSFRMAIEWLTVLLQGSAPAPHQLRLVIVPAVIGLALGVMIRYVFPDVRGSGVNQTKAALYIHNGYISTKTMIGKFLLAALSIGSGQSLGPEDPSLHFGAGVASRIGRYMGLSRERMRLFAPVGAAAGLAAAFNAPISAVLLVIEEVIGQWTAAILGSIVLSAVSAVVVARWFWGPQPMFRIPPVTLRDPRELLAYAVLGVVGGFASLALTKALAYLRPRLRSQSANRQMFMPALAGLFVGGIAYFGVPQVLGVGYGAMDAAMHAQYTIGFLLLLAGLKLVASTVSFSSGAPGGLFATALFLGAMLGSVVGTVEHGLFPSLTGSVGSYALVGMGVFFAAFIRVPLTSVFMILEMSGNYSVILPVILANTIAYLISRSLQPVPILELFTHQDGLYLPSMEEEREDSQLHFEDALKPSSAPILPGGEKLNELAKTVENNSEIAHAAAVLIQCSDGWYAATQTELQQMLTNASADREGAGAKTLEQSVGQARTPLLFPDQPLANALPFFKIWPLLPISNRAIRGVIEGVLTLDDVLKRYQRS
>NC_018014.1|WP_014785667.1|2145912_2146170_-|glutaredoxin-family-protein
MDLKVYTASWCRDCFVAKRFLQQHSIAFTEIDIERTPGAVDALLQNVGKKAIPQFVIDGKWVQPYKPGQGFLYEEMSLLLGVTKA
>NC_018014.1|WP_014785668.1|2146193_2146970_-|glucose-1-dehydrogenase
MSEGKLAGKVALITGSSSGIGQGIAIRMAKDGADIVVNYSGHIEGAQETQQEIEALGRKAFIVRADVSKVAECQSLVQAGWDQFGKIDILVNNAGVEKGSDFVDVTEADYDLVLDVNLKGPFFTTQAFVKRVLAAKIPGRVINISSVHEDMVFPHFASYCASKGGIRMLMRDLAVELGPKNITVNNIAPGAIITPINKKLLDDKAKLDPLLANIPLGRMGSIDDVSALAAFLASDEAAYVTGSTYFVDGGLMRNYHEQ

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Crispr_ID: NC_018014_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_7

2140774-2140863

Orphan

Consensus_repeat	Method
GAGGCGGGCTGAAGGCCCGCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018014_7

>merge|NC_018014|7|2140774-2140863|CRISPRCasFinder
GAGGCGGGCTGAAGGCCCGCGACTTCCTAGCCCAGGGCGAAGCCCTGGGTCACCACCGGCAACAAAGCAGGCGGGCTGAAGGCCCGCGAC

>NC_018014|7|6|2140774-2140863|CRISPRCasFinder
GAGGCGGGCTGAAGGCCCGCGAC	TTCCTAGCCCAGGGCGAAGCCCTGGGTCACCACCGGCAACAAAG
CAGGCGGGCTGAAGGCCCGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_041592523.1\|2139496_2140291_-\|TIGR00282-family-metallophosphoesterase	unknown	unknown	gnl\|CDD\|379099
NC_018014.1\|WP_014785657.1\|2131426_2132752_+\|L-fucose:H+-symporter-permease	unknown	unknown	gnl\|CDD\|340952
NC_018014.1\|WP_014785663.1\|2140879_2141464_-\|YkgJ-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|308985
NC_018014.1\|WP_014785670.1\|2148788_2149835_+\|low-specificity-L-threonine-aldolase	unknown	unknown	gnl\|CDD\|224919
NC_018014.1\|WP_014785659.1\|2133400_2137273_-\|chromosome-segregation-protein-SMC	unknown	unknown	gnl\|CDD\|274008
NC_018014.1\|WP_014785655.1\|2129748_2130351_-\|CvpA-family-protein	unknown	unknown	gnl\|CDD\|367140
NC_018014.1\|WP_157178300.1\|2142941_2144120_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_018014.1\|WP_014785664.1\|2141556_2142876_-\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|176464
NC_018014.1\|WP_014785669.1\|2147066_2148497_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NC_018014.1\|WP_014785660.1\|2137729_2139064_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014785661.1\|2139136_2139493_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014785666.1\|2144116_2145853_+\|chloride-channel-protein	unknown	unknown	gnl\|CDD\|238233
NC_018014.1\|WP_014785672.1\|2150782_2151265_+\|DUF3455-domain-containing-protein	unknown	unknown	gnl\|CDD\|314761
NC_018014.1\|WP_014785654.1\|2129446_2129737_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|225114
NC_018014.1\|WP_014785653.1\|2127527_2129411_-\|Flp-pilus-assembly-protein,-secretin-CpaC	unknown	unknown	gnl\|CDD\|333965
NC_018014.1\|WP_014785668.1\|2146193_2146970_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|187616
NC_018014.1\|WP_014785656.1\|2130356_2131250_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
NC_018014.1\|WP_014785667.1\|2145912_2146170_-\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|239274
NC_018014.1\|WP_014785671.1\|2149859_2150771_+\|carbon-nitrogen-hydrolase	unknown	unknown	gnl\|CDD\|143597
NC_018014.1\|WP_014785652.1\|2125008_2126988_+\|carbohydrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|226064

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_041592523.1\|2139496_2140291_-\|TIGR00282-family-metallophosphoesterase	gnl\|CDD\|379099	pfam13277, YmdB, YmdB-like protein. This family of putative phosphoesterases contains the B. subtilis protein YmdB.	9.91531e-148
NC_018014.1\|WP_014785657.1\|2131426_2132752_+\|L-fucose:H+-symporter-permease	gnl\|CDD\|340952	cd17394, MFS_FucP_like, Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.04969e-131
NC_018014.1\|WP_014785663.1\|2140879_2141464_-\|YkgJ-family-cysteine-cluster-protein	gnl\|CDD\|308985	pfam03692, CxxCxxCC, Putative zinc- or iron-chelating domain. This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex. However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.	0.0035938
NC_018014.1\|WP_014785670.1\|2148788_2149835_+\|low-specificity-L-threonine-aldolase	gnl\|CDD\|224919	COG2008, GLY1, Threonine aldolase [Amino acid transport and metabolism].	2.83364e-143
NC_018014.1\|WP_014785659.1\|2133400_2137273_-\|chromosome-segregation-protein-SMC	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0
NC_018014.1\|WP_014785655.1\|2129748_2130351_-\|CvpA-family-protein	gnl\|CDD\|367140	pfam02674, Colicin_V, Colicin V production protein. Colicin V production protein is required in E. Coli for colicin V production from plasmid pColV-K30. This protein is coded for in the purF operon.	2.61329e-23
NC_018014.1\|WP_157178300.1\|2142941_2144120_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	3.73069e-09
NC_018014.1\|WP_014785664.1\|2141556_2142876_-\|adenylosuccinate-lyase	gnl\|CDD\|176464	cd01360, Adenylsuccinate_lyase_1, Adenylsuccinate lyase (ASL)_subgroup 1. This subgroup contains bacterial and archeal proteins similar to ASL, a member of the Lyase class I family. Members of this family for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. ASL catalyzes two steps in the de novo purine biosynthesis: the conversion of 5-aminoimidazole-(N-succinylocarboxamide) ribotide (SAICAR) into 5-aminoimidazole-4-carboxamide ribotide (AICAR) and, the conversion of adenylsuccinate (SAMP) into adenosine monophosphate (AMP).	0
NC_018014.1\|WP_014785669.1\|2147066_2148497_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	1.31425e-97
NC_018014.1\|WP_014785672.1\|2150782_2151265_+\|DUF3455-domain-containing-protein	gnl\|CDD\|314761	pfam11937, DUF3455, Protein of unknown function (DUF3455). This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 174 to 251 amino acids in length.	2.65468e-28
NC_018014.1\|WP_014785666.1\|2144116_2145853_+\|chloride-channel-protein	gnl\|CDD\|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	3.06971e-101
NC_018014.1\|WP_014785654.1\|2129446_2129737_-\|histidine-kinase	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.29549e-06
NC_018014.1\|WP_014785653.1\|2127527_2129411_-\|Flp-pilus-assembly-protein,-secretin-CpaC	gnl\|CDD\|333965	pfam00263, Secretin, Bacterial type II and III secretion system protein.	1.65767e-18
NC_018014.1\|WP_014785668.1\|2146193_2146970_-\|glucose-1-dehydrogenase	gnl\|CDD\|187616	cd05358, GlcDH_SDR_c, glucose 1 dehydrogenase (GlcDH), classical (c) SDRs. GlcDH, is a tetrameric member of the SDR family, it catalyzes the NAD(P)-dependent oxidation of beta-D-glucose to D-glucono-delta-lactone. GlcDH has a typical NAD-binding site glycine-rich pattern as well as the canonical active site tetrad (YXXXK motif plus upstream Ser and Asn). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	6.96535e-99
NC_018014.1\|WP_014785656.1\|2130356_2131250_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	9.88857e-179
NC_018014.1\|WP_014785667.1\|2145912_2146170_-\|glutaredoxin-family-protein	gnl\|CDD\|239274	cd02976, NrdH, NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase activity that is dependent on TRX reductase, not glutathione (GSH). It is part of the NrdHIEF operon, where NrdEF codes for class Ib ribonucleotide reductase (RNR-Ib), an efficient enzyme at low oxygen levels. Under these conditions when GSH is mostly conjugated to spermidine, NrdH can still function and act as a hydrogen donor for RNR-Ib. It has been suggested that the NrdHEF system may be the oldest RNR reducing system, capable of functioning in a microaerophilic environment, where GSH was not yet available. NrdH from Corynebacterium ammoniagenes can form domain-swapped dimers, although it is unknown if this happens in vivo. Domain-swapped dimerization, which results in the blocking of the TRX reductase binding site, could be a mechanism for regulating the oxidation state of the protein.	6.05107e-17
NC_018014.1\|WP_014785671.1\|2149859_2150771_+\|carbon-nitrogen-hydrolase	gnl\|CDD\|143597	cd07573, CPA, N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases). CPA (EC 3.5.1.53, also known as N-carbamoylputrescine amidase and carbamoylputrescine hydrolase) converts N-carbamoylputrescine to putrescine, a step in polyamine biosynthesis in plants and bacteria. This subgroup includes Arabidopsis thaliana CPA, also known as nitrilase-like 1 (NLP1), and Pseudomonas aeruginosa AguB. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 11. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer; P. aeruginosa AugB is a homohexamer, Arabidopsis thaliana NLP1 is a homooctomer.	1.90048e-172
NC_018014.1\|WP_014785652.1\|2125008_2126988_+\|carbohydrate-binding-domain-containing-protein	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	1.59001e-47

>NC_018014.1|WP_041592523.1|2139496_2140291_-|TIGR00282-family-metallophosphoesterase
MNILFVGDIFGSAGRRIVAEHIGHVLESNAIDLCVINGENAAGGFGITPSIADDIFDLGADVITTGNHFWDKKELLDYLKVPADSHGRPRRILRPANFAPKTPGFGVYESALPTGQPYAVVNLQGRVFMQQNDDPFRKADEMLASIKAKVILVDFHAEASSEKVAMGWYLDGRVTAVLGTHTHIPTADERVLPGGTAFQTDVGMSGPYDSVIGVEKEAVIERFLTGQPAKFEAAKGNPKMCAAVIECDGATGRAYRIKRVMLGE
>NC_018014.1|WP_014785661.1|2139136_2139493_+|hypothetical-protein
MLPSNRITNALLAVIAVALTAIAARPYVQPTPVAAQSSTFASQAGNADPIYVEPGVYMLRRPEGGQVLGKVTINLRTGNVWGFPTGTPDPYPVTPLDSKPQISHAIPLGRFAVGEADR
>NC_018014.1|WP_014785660.1|2137729_2139064_+|hypothetical-protein
MKKAFLASMLAAACVSATYAVAQTPVNTNNGAAAQGPQLSADEYTAYQAVITATDPAAKATAAEAFLTKFPQSSVKSTVLEQLVAGYAGSNNVPKTLESADKLLQVDPNNIRALALETSLLKAQGDSATDPAAKQSAYDKAADAASRGLKATKPAAVADADWAAIQKQVTPYFYSAIGIDALTKKDSAGAIAAYTSELKAVDVAATTQPGPVLQDTYFLGQAYYTSTPPDYLNCTYFATRTAIYAPEQFKSTFQPLATYCYKKFHGAEDGYDAVKAVAKDNLFPPADFATSVKPAPTPADQATTVFEADKKEDPTLTKTNIADREFVITNGTTEQAEAEFAPIKDKEVKLTGKVVSIADTTLTLAVSDDAKQANPLVADVSVTLTEAPKVAPVVGADVTVVGSMASYTQKPMMFTMTGGTIEGKAAAKAPAKAAPARRAPARKR
>NC_018014.1|WP_014785659.1|2133400_2137273_-|chromosome-segregation-protein-SMC
MLKLKRVQILGFKSFCDRTDVQLSGNGIAAIVGPNGCGKSNISDAITWVLGEQSAKSLRGVKMEDVIFAGTRDRKPTGMAEVSLTLVDPDVYDASDAGETINMGSVTPKPAEINDWDETAERNMSAEATLAAVAEAQPGPIPADEESEEIEVDAPVDSTAELAAAEAGTVAPNPLVLKIRRRKFNRAPVRAGEITVTRRLFRSGESEYLLNGKICRLRDIQDIFFGTGLSGENYAIIGQERIGQLLSSKPLDRRSIIEEAAGITRFKTKKRLAELRLEAAKQNLARVDDIFDEVTRQMGSLKRQAAKAERYGQMRDELRAKLRVVLRSRLSQHDADRAASEASVTKLTASIDEQAGSLEALDAEHTAGVARGYELDEETRAAQSRINETRIELERATARIHSNTDRVTDLAARIASGTEELAQLKHQIEALSADRDGLRLFLETATADTEEAKQTAQTKQREANEAQAQVNNTDREAGNGRHQSMQLMQRISNVHREEAQAAESLAGLEREAERLIGESEQAKVELEALGKQRGQVSMTFESVTDRLKRLEAEIAQLRLDLDAKRREEMETRRRGDHLRAEAATLTGRKNSLEALIRDHSYSSETVRKLFKANGIATSVAPVGTLADFLEVDDEHGAVVDEFLKEELNYIVVKDWNSADAGIGLLKGNVDGRATFLVHSESAPKYGDGMASRSAGDLRGARPLKDCIRVLNGFGRSLEVILPKLREGFIAPDSETARTLAIENPEAFFLSPSGETFHNMTVTGGKARSGGPLALKSELREIQTKLEGVQAELAQSEIGVAALAKQIQEMQHAVEAKGNERREAEREAANSGAALRQMDSEAARIEKRLADWSLHSERNRDARAQKQDLIERKQAEASQLMMEREAIDVRVSDTLLRIEDLRRQREEVQAAAAAASAALAGLEERRRNASSNFEQNERMRNTTQQRILHLEGQNASAAAERTRREEETVQLIEQQAELTAQREQLSAEAQRLGAEATALRASIGEKNGLLRSLRTEIEGLREQRGTLQTTIARLSSEIEHLEAQSLNDLNMPAEELRADTTIEPITAEALDAADEETRTLKGKLEAMGPVNMMALEEFAEAEQRHSFLETQRKDLLDSISNTQGAIKEIDEISKIKFDDAFAIINKNFSETFVKLFGGGQATMKLTDESNSAESGIDLVASPPGKKMQNVLLLSGGEKALTALSLLVGIFEFQPSPFCVLDEVDAPLDETNVGRFARLIHEMSKDTQFVVITHHKRTMTEADVIYGVTMQEPGVSKIVSVNLNKAETRRVA
>NC_018014.1|WP_014785657.1|2131426_2132752_+|L-fucose:H+-symporter-permease
MHGPPVATTRHAVHEAPDLNTPLFSPSHRTAFFVVTALFFLWALPNNLNDVLIRQFMKAFQLSRLQGGLVQSAFYFGYFCISMPAAYVLRRWGYRVGLVTGVLLYGVGCLLFWPAALANQYSFFLIALFVIAAGLAFLETGGASFITLLGDPSTSERRLNFAQAFNPPGTIAGALIGTVFIFSGIEPSATETAQMKAAGTYAAFLHRETLRVTTPYLVLALVVFLFAILLMRVKFPARTLSQDQFPFEERGTTASLIHVPHFVWAVISQFFYVGAQVASWSFLIQYAHDYAHQPEKIAGYFLSGSLAIFSVGRFAATALMKYVRPNVLMGIFALINVALLVLVILFPGWVGLWALMFTSFFMSLMYPTNFALGLKGLGANTTLGASVLVMAIIGGAVATPVVGWVAEQTGSMAMSFIVPLLCYLVVAYFAFIGSKVRTQVS
>NC_018014.1|WP_014785656.1|2130356_2131250_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MILGDLKPILTGKVRDLYEVGTDRLLFVASDRISAFDHVLGSLVPDKGKVLTQLSLFWFDYLRNLVPNHLITADVRDYPADLQVYSDALRGRSMIVQRARMVQVECVARGYLSGSGWKDYQQTGAVCGIALPSGLRESDRLPEPIFTPAAKNHTGHDENVGFDHVVDAVGPELAERLRSLTLAIYGAASKYAESKGLILADTKFEFGFVPSKDGGDLLVLADEVLTPDSSRYWLASGYAPGGAQPSFDKQFVRDYLERIQWNKQLPAPALPDEVVEETRAKYLQAFTLLTGKQELPE
>NC_018014.1|WP_014785655.1|2129748_2130351_-|CvpA-family-protein
MNNTLHGVTIGLNGMNPLDWTIALVLAISVVTAFMRGLIRSVVSLAGLLAGILAACWYAPKGAAYLARWVTPFAFAEIVAFVLILAGVYVLAALLGRVLSGAAGAVGLGFLDRLGGACFGFVRGVLLLASLVLPFGPFLHDFRAAKDSVLLPYLLPAAHGISFVVPRDFGKRLPASDWWNHARSAAGELAPIGKRTTPSD
>NC_018014.1|WP_014785654.1|2129446_2129737_-|histidine-kinase
MKRELDILVAQMHADGISYEEAVREFKRRYLLQVLVNHRGNQCKSAEELGMHRNTLSRTLAELDMDTAQIRSGLKRPARSDRAAGTPRLQTIARVR
>NC_018014.1|WP_014785653.1|2127527_2129411_-|Flp-pilus-assembly-protein,-secretin-CpaC
MTASLPHRRGVSLGCIAALLLSPLAQAQTAAPTPKPLTPLSAKQRARAEDAYLSGAKHLSKAEFLPAEKDFARAIVVDPSRPEYVQALVLSREHRVTNLLQQAAATRPRDAAAADALVGQARALDRDNPRVTQHDGPTAIKPVRKMEVVGGVVLLHTNTRHSYHERSDIRTLASHIAADYGLKAVLDTEVPTKSYRIDVDDASYDEVMSVFSVLTNMMSVPLDEHTLLFAMDTVANRQRYERLVEAVYYLPAFTADQLKDFVSIAQNVLTLKQVSVKPGDGSLVVRGPADLVDAADKIFADLMTGGSDVVIDMKLYAIEKSRTQNLGVVLPSSLNAFSLASQAQSIVSANQSLITQLIASGVIPSTTSVYELAAYLVFVAGVGGTSSLLSNSFLIFGGGATTGVLSAGNIPTINLALNQSDARSLEDVQLRGSDRQTIIFKAGTRYPIQTSLFSDIASNASSALGNTTVNGVSLSSLLSQYLGTNSSGSNGIIPQFQYEDLGLVITAVPRILRTGDVSMHLEIKVSALSGAALNGIPILSSRQFSSDLTMADGDTALMVSDTTQNETTAVTGVPGLSELPGFQGGTNRNGTRSTGDLVLMLTPHIVRLGHRSPTGPYIALPPRPDDE
>NC_018014.1|WP_014785652.1|2125008_2126988_+|carbohydrate-binding-domain-containing-protein
MNRRHFVLSTIAATAALPIRATPWLSVADAETLEPGVAVLLVDTDRKTAPIDRNIYGQFLEHINHSVEDGLYAEQIQGAGFEGDDFKTYWKPSSEKGHVELIDLEFQNGKKSVRLTAQGGHASIRQGRIFLEQGSRYEGSLWVKRERGSSHLTLRVLGHAGEQIASLPIAVTGSEWKELPFSFTSTVRDTQASIELTASGNGSILVDFISMMSAAARANGMFRHDLYSAFNDLKPAFIRWPGGSFASTYRWKEGIGRYAARGYHPNTYWGGYSDYFGFGTDEFLSLCKKLKAEPLITLPATSTKPEDVQYAIDWIHYVNDPPTTEMGKLRAANGHPEPYNVKLFQIDNEPMNNGFTPDAYAEIVNVYGPRIRAAAPSAKVVACGQKRSNDMEWSEKVIDLAGKNFDVLGCHNYEYEPDNFETGVRRIHEYLVKLRDHVHNSDHPKIEIAVLEWSLQHTYDWRAGLHAAGSLMMYESLSPALSMTCPALLMRNITDDPTWTSSIYHDHVSWFPGGSYPVEKLFSDCYAERFLASTSGTFRDQPNRAILFDKISTAIPKGWIPGSVDAVATASEDNRRMVIKAVNYRGVKADLLVRLQGARTPKNATAVLHTITAAPTAAASIENPNAILTETKSFPYTSEFTINLAPYTVAVLEITGSAA
>NC_018014.1|WP_014785663.1|2140879_2141464_-|YkgJ-family-cysteine-cluster-protein
MLPQGDRELVQIMDAALADAAVRSGHWLACRPGCNQCCSGVFRIGPLDAERLREGLRLLGDEKAGLIRDRVRESVARLSPGFPGDTDTGLLFEDDDSLERFEDFADDEVCPVLDPVTGTCDLYAHRPMTCRTFGPPVRTGDEGFGVCELCFVGAPEEAVAAAELHLPDPDLEARLDFETGLSGTTVVAFALLGV
>NC_018014.1|WP_014785664.1|2141556_2142876_-|adenylosuccinate-lyase
MIDRYTRPAMRTLWSDESKFRAWLEVEATASEVLADAGIVPQDAAKAIRTRGDFDIARILEIEQQTRHDVIAFTTAVAEKVGPEARWLHFGLTSTDVVDTAQALLLREASSIIREGLVALSVVLKRRAIEFALTPCIGRTHGVHAEPTTFGLKLLLWYTECQRNIVRFDAAAAGMNVGKLSGAVGSYGTVTPALEEEICTRLGLDTALVSTQVLQRDRHAAYIGALSVMASSLDRIATEVRHLQRTEVREAEEFFSEKQKGSSAMPHKRNPITCENICGLARVMRANSQVALEDVALWHERDISHSSAERVILPDTTTLADYMLSKTTNLIDKLMVYPERMLKNLNLTGGLVFSGQLLLDLAEAGMSREDAYKTVQTLAMKAWKEDLVFKELVAADAQITALLAPERIVRAFDVNRRLENVPAIFERVFGKPLSELQGK
>NC_018014.1|WP_157178300.1|2142941_2144120_+|tetratricopeptide-repeat-protein
MEAGSKQAAAPLPPTPAQASRRRLMIRDGLKFLTLTLVAVVLSGVTTFLFRSFESRRERLAERWAQRGHDAMQRGQSEQAVAALRVSLSYHPDDYENQLALAEALAAGGHVDEAENYYLNLWQSRPGDGPINLQLARLERTRGRDQQAIDYYRAAVFGTWAGDAPARRRDTRLELSRYLVDRGQPLAAQAELLIAAGNNPDPATQLRIAEALEAAGDTSSALTAYRRAEVGSQLHTAQARAGELCFRAGDYTCAEDSLEKALRSKTWTAEQITRLNGMHDDAARLQELAFSPVVPPALRSAHLLSDSVIALNRFKTCTDPSLMPLQTRWKALNTPQNRAALRHDDDVQLQYANLIFETEITAAKTCGTPIGDDALLLHLQDHPMTRIGAQQG
>NC_018014.1|WP_014785666.1|2144116_2145853_+|chloride-channel-protein
MSTLISNEKETSTDSSPMREERLFLLLSIFIGIISGLVVVSFRMAIEWLTVLLQGSAPAPHQLRLVIVPAVIGLALGVMIRYVFPDVRGSGVNQTKAALYIHNGYISTKTMIGKFLLAALSIGSGQSLGPEDPSLHFGAGVASRIGRYMGLSRERMRLFAPVGAAAGLAAAFNAPISAVLLVIEEVIGQWTAAILGSIVLSAVSAVVVARWFWGPQPMFRIPPVTLRDPRELLAYAVLGVVGGFASLALTKALAYLRPRLRSQSANRQMFMPALAGLFVGGIAYFGVPQVLGVGYGAMDAAMHAQYTIGFLLLLAGLKLVASTVSFSSGAPGGLFATALFLGAMLGSVVGTVEHGLFPSLTGSVGSYALVGMGVFFAAFIRVPLTSVFMILEMSGNYSVILPVILANTIAYLISRSLQPVPILELFTHQDGLYLPSMEEEREDSQLHFEDALKPSSAPILPGGEKLNELAKTVENNSEIAHAAAVLIQCSDGWYAATQTELQQMLTNASADREGAGAKTLEQSVGQARTPLLFPDQPLANALPFFKIWPLLPISNRAIRGVIEGVLTLDDVLKRYQRS
>NC_018014.1|WP_014785667.1|2145912_2146170_-|glutaredoxin-family-protein
MDLKVYTASWCRDCFVAKRFLQQHSIAFTEIDIERTPGAVDALLQNVGKKAIPQFVIDGKWVQPYKPGQGFLYEEMSLLLGVTKA
>NC_018014.1|WP_014785668.1|2146193_2146970_-|glucose-1-dehydrogenase
MSEGKLAGKVALITGSSSGIGQGIAIRMAKDGADIVVNYSGHIEGAQETQQEIEALGRKAFIVRADVSKVAECQSLVQAGWDQFGKIDILVNNAGVEKGSDFVDVTEADYDLVLDVNLKGPFFTTQAFVKRVLAAKIPGRVINISSVHEDMVFPHFASYCASKGGIRMLMRDLAVELGPKNITVNNIAPGAIITPINKKLLDDKAKLDPLLANIPLGRMGSIDDVSALAAFLASDEAAYVTGSTYFVDGGLMRNYHEQ
>NC_018014.1|WP_014785669.1|2147066_2148497_-|glutamine-synthetase
MSGNYREFLELSYEELEELNLAAKDQRKKHVAIGKIQEERLKYLTDTKGIKAVTVVFSDLEGRMHMLDYDKKFLVNSYDNLTFDGSSIRGFTAQKESDLRLGLDWNAFYWTPADVFGSGKVMVFGEVIDKSGGPYSADLRGILKQYANKLYDEKGYTLNAANEVEGFLFEGVDAERSFHKTGSFEYVNGGGYYNSLPGDPLREFIDTAAEVQRAMGFENEKDHPEVAPSQFEINYTYGDVVSAADQIQLYKLICRQVATQMGMTASFLPKPVTGVNGSGMHTNVSITKDKKNLFFDKAGEEGMSEMAWSFIDKILTHGNDICLLLNSSVNAYRRLDPHFEAPNQIKASATDRGSMVRIPIGNEKSARVEVRSVGPDANPYGVLYSVFKTGLDGQVGQIENLRQASRYLPDNIYTAIENFRGSDWTTTLLGADVKERFAELKQASADRCPRLLGSVVKGPEVQFHHEIYNQLLWGQF
>NC_018014.1|WP_014785670.1|2148788_2149835_+|low-specificity-L-threonine-aldolase
MTHISTDNSQQFASDNYSGICPEAWAAMAEANQGHATAYGDDPWTQRASDLFRDLFETECEVFFAFNGTAANSLSLAALCQSYHSVICAQSAHVETDECGAPEFFSNGSKLLTAQTTDGKMTPAAIRTLATSRNDIHFPKPKAVTITQSTETGRVYSLDELSQLSATCRELKLHLHMDGARFANAVASIGCTPAEMTWKAGVEVLCFGGTKNGMAIGEAIVFFDHTLAQDFDYRCKQAGQLASKMRFLSSPWVGMLESGAWQRNAQHANACATRLRESISGITQGSIMYPTEANAVFLMSDEARLEQLRERGWRFYTFIGGSARFMFAWDTDLARVDQLAADIREIMA
>NC_018014.1|WP_014785671.1|2149859_2150771_+|carbon-nitrogen-hydrolase
MKKTKIALIQMSCVPDTGKNLEHAAELVIEAAKNGADLVCLPELFRAQYFCQREDHALFATAESIPGPSTERLGAIAKEHGIVIIASLFERRAPGLYHNTAVTIERDGSIGDVYRKMHIPDDPLYYEKFYFTPGDLGFKAFASSAGNIGTLVCWDQWYPEGARITALKGAETLFFPTAIGWHPSEKEEYGDAQYDAWQTTQRAHAISNGVWVCAVNRVGFEHGDVVHNGVDMPGPEGAGLEFWGGSFIADPFGRIVARASHDKEEILYADIDPAQVEITRQHWPFLRDRRIDAYEGVTKRFLI
>NC_018014.1|WP_014785672.1|2150782_2151265_+|DUF3455-domain-containing-protein
MKVKALALLLLLAIGAHAQDVTEPPATAKVKYTVLGIGRQVYACGEDGKWTLQEPQADLIDTQTHQPVGTHTKGPTWTWSDGSAITGKVLQQRVSADSIPWLLLQVQSSGGSGALSTIAFIRRSDTQGGVPQAANICGAQNVGSTINVPYQATYTFYTAQ

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Crispr_ID: NC_018014_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_8

3773094-3773410

Orphan

Consensus_repeat	Method
CTCATTTCCAGCCAGGTCCGGGA	CRISPRCasFinder
TTTCCAGCCAGGTTCGGG	PILER-CR

5 spacers

The CRISPR arrays of NC_018014_8

>merge|NC_018014|8|3773094-3773410|CRISPRCasFinder,PILER-CR
GAAATTTCCAGCCGGGTCCGGGAAGATTACCAGCCGAGTCCGGGAGGCCTTCCAACAGGGTTCGGACCACAGTTCCAGCGGGGTTCGGAACGTTTTCCAGCCAAGTACGGCAATATTTCCAGCCGGGTCCGGGGCCTCATTTCCAGCCAGGTCCGGGAACAAAAGGGGCTCTCGCTCCGATTAGCGCGCTCATTTCCAGCCAGGTGCGGGACTCGTGGGTCATATGTTGGGATAAGGAGCTCGTTATTTCCAGCCCGGTTCGGCAATTCGCCTCGGAAGGGCGCCTCAGACTCAAGCTTTTCCAGCCGGGTTCGGGT

>NC_018014|8|7|3773094-3773410|CRISPRCasFinder
GAAATTTCCAGCCGGGTCCGGGA	AGATTACCAGCCGAGTCCGGGAGGCCTTCCAACAGGGTTCGGAC
CACAGTTCCAGCGGGGTTCGGAA	CGTTTTCCAGCCAAGTACGGC
AATATTTCCAGCCGGGTCCGGGG	CCTCATTTCCAGCCAGGTCCGGGAACAAAAGGGGCTCTCGCTCCGATTAGCGCG
CTCATTTCCAGCCAGGTGCGGGA	CTCGTGGGTCATATGTTGGGATAAGGAGCTC
GTTATTTCCAGCCCGGTTCGGCA	ATTCGCCTCGGAAGGGCGCCTCAGACTCA
AGCTTTTCCAGCCGGGTTCGGGT

>NC_018014|8|1|3773233-3773409|PILER-CR
TTTCCAGCCAGGTCCGGG	AACAAAAGGGGCTCTCGCTCCGATTAGCGCGCTCA
TTTCCAGCCAGGTGCGGG	ACTCGTGGGTCATATGTTGGGATAAGGAGCTCGTTA
TTTCCAGCCCGGTTCGGC	AATTCGCCTCGGAAGGGCGCCTCAGACTCAAGCT
TTTCCAGCCGGGTTCGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_014786599.1\|3762065_3763031_+\|nucleotidyltransferase	unknown	unknown	gnl\|CDD\|143390
NC_018014.1\|WP_014786607.1\|3770430_3771129_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|349760
NC_018014.1\|WP_014786606.1\|3769458_3770007_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786608.1\|3771435_3772971_-\|replication-initiator-protein-A	unknown	unknown	unknown
NC_018014.1\|WP_157178392.1\|3778446_3779325_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271188
NC_018014.1\|WP_014786602.1\|3764496_3766032_+\|SAVED-domain-containing-protein	unknown	unknown	gnl\|CDD\|380122
NC_018014.1\|WP_014786601.1\|3763564_3764500_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|224144
NC_018014.1\|WP_014786620.1\|3785816_3787328_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_018014.1\|WP_014786621.1\|3787851_3788064_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786598.1\|3761755_3761962_-\|transcriptional-regulator	unknown	unknown	unknown
NC_018014.1\|WP_014786609.1\|3773852_3774089_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380292
NC_018014.1\|WP_157178391.1\|3775612_3777427_+\|type-IV-secretion-system-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|313610
NC_018014.1\|WP_014786605.1\|3768396_3769335_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271175
NC_018014.1\|WP_014786612.1\|3775052_3775463_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_157178393.1\|3785378_3785681_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786614.1\|3777475_3778447_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271178
NC_018014.1\|WP_014786600.1\|3763043_3763562_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375583
NC_018014.1\|WP_014786616.1\|3779760_3781635_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|224875
NC_018014.1\|WP_014786618.1\|3782027_3784784_+\|relaxase-domain-containing-protein	unknown	unknown	gnl\|CDD\|378042
NC_018014.1\|WP_014786604.1\|3766635_3768321_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_014786599.1\|3762065_3763031_+\|nucleotidyltransferase	gnl\|CDD\|143390	cd05400, NT_2-5OAS_ClassI-CCAase, Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme. In vertebrates, 2-5OASs are induced by interferon during the innate immune response to protect against RNA virus infections. In the presence of an RNA activator, 2-5OASs catalyze the oligomerization of ATP into 2-5A. 2-5A activates endoribonuclease L, which leads to degradation of the viral RNA. 2-5OASs are also implicated in cell growth control, differentiation, and apoptosis. This family includes human OAS1, -2, -3, and OASL. CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This class I group includes the archaeal Sulfolobus shibatae and Archeoglobus fulgidus CCA-adding enzymes. It belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this family.	1.09369e-19
NC_018014.1\|WP_014786607.1\|3770430_3771129_-\|ParA-family-protein	gnl\|CDD\|349760	cd02042, ParAB_family, partition proteins ParAB family. ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.	8.65579e-31
NC_018014.1\|WP_014786600.1\|3763043_3763562_+\|hypothetical-protein	gnl\|CDD\|375583	pfam18138, bacHORMA_1, Bacterial HORMA domain family 1. Family of bacterial HORMA domains found in conserved genome contexts with Pch2/TRIP13 P-loop NTPases. Acts as a 'third component' in broad class of conflict systems reliant on the production of second messenger nucleotide or nucleotide derivatives. Together with Pch2/TRIP13, could act as co-effectors or in regulation of other effectors of the systems.	2.00846e-64
NC_018014.1\|WP_014786620.1\|3785816_3787328_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	9.08031e-14
NC_018014.1\|WP_014786602.1\|3764496_3766032_+\|SAVED-domain-containing-protein	gnl\|CDD\|380122	pfam18145, SAVED, SMODS-associated and fused to various effectors sensor domain. Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. The sensing of ligands by SAVED is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.	5.2135e-30
NC_018014.1\|WP_014786601.1\|3763564_3764500_+\|AAA-family-ATPase	gnl\|CDD\|224144	COG1223, COG1223, Predicted ATPase (AAA+ superfamily) [General function prediction only].	3.26263e-15
NC_018014.1\|WP_157178392.1\|3778446_3779325_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271188	cd01188, INT_RitA_C_like, C-terminal catalytic domain of recombinase RitA, a component of the recombinase trio. Recombinases RitA (also known as pAE1), RitB, and RitC are encoded by three adjacent and overlapping genes. Collectively they are known as the Recombinase in Trio (RIT). This RitA family includes various bacterial integrases and integrases from the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus H1. All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.50086e-77
NC_018014.1\|WP_014786609.1\|3773852_3774089_-\|hypothetical-protein	gnl\|CDD\|380292	NF033450, BREX_PglZ_1_B, BREX-1 system phosphatase PglZ type B. BREX (bacteriophage exclusion) is a phage resistance resistance, in which two protein families are core but other proteins are variable. BREX subtypes are based on PglZ domain protein, a putative phosphatase. This family is one of two major subtypes of PglZ as seen in type 1 BREX systems. Most members of this family contain an additional C-terminal domain that is not included in the seed alignment. Family TIGR02687 describes the alternative type A for PglZ of BREX-1.	0.00263792
NC_018014.1\|WP_157178391.1\|3775612_3777427_+\|type-IV-secretion-system-DNA-binding-domain-containing-protein	gnl\|CDD\|313610	pfam10412, TrwB_AAD_bind, Type IV secretion-system coupling protein DNA-binding domain. The plasmid conjugative coupling protein TrwB forms hexamers from six structurally very similar protomers. This hexamer contains a central channel running from the cytosolic pole (made up by the AADs) to the membrane pole ending at the transmembrane pore shaped by 12 transmembrane helices, rendering an overall mushroom-like structure. The TrwB_AAD (all-alpha domain) domain appears to be the DNA-binding domain of the structure. TrwB, a basic integral inner-membrane nucleoside-triphosphate-binding protein, is the structural prototype for the type IV secretion system coupling proteins, a family of proteins essential for macromolecular transport between cells and export.	1.08232e-83
NC_018014.1\|WP_014786605.1\|3768396_3769335_-\|site-specific-integrase	gnl\|CDD\|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	2.74351e-31
NC_018014.1\|WP_014786614.1\|3777475_3778447_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271178	cd00797, INT_RitB_C_like, C-terminal catalytic domain of recombinase RitB, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	8.94943e-40
NC_018014.1\|WP_014786616.1\|3779760_3781635_-\|radical-SAM-protein	gnl\|CDD\|224875	COG1964, COG1964, Predicted Fe-S oxidoreductases [General function prediction only].	2.80521e-61
NC_018014.1\|WP_014786618.1\|3782027_3784784_+\|relaxase-domain-containing-protein	gnl\|CDD\|378042	pfam08751, TrwC, TrwC relaxase. Relaxases are DNA strand transferases which function during the conjugative cell to cell DNA transfer. TrwC binds to the origin of transfer (oriT) and melts the double helix.	3.42361e-94

>NC_018014.1|WP_014786608.1|3771435_3772971_-|replication-initiator-protein-A
MAKRPEANQKTIALPDAIDLIRFEKNLLQIGFFSAHDRRSNDPDLSRRIEQWVNRDGKRIRVSAEFRSTLGLPSTSDRDKYMAFMKIAMERKMMEGEITNPIRFSGYSMLKALGLSDSGANYEDLNQWGMRMADTTITSEQIIYSSSRRKFMNKTVHVFRSFTRTGESDNDGGNQTVQFAVELEDWLLENLNQSYVVPEDFTQYRKLVRPTAKGIFVYLYVWFYASRGKEVEKDYGELCALLNVRCYQHVSKIRETMGLSLDDLVGIGYLQKWDIRSMSSKKGFKLVLSPGRAILDVIATAQRRQLVSTANHTELVGAQSELSDALVSRGVAEDKAAAICRAHDPDVVKDQLEYLDSEIARDGGRRIKNPAGFIIAFIDGGKGVPLTFETTRKRDERRSLLTEQLASHEEQIGREIQELTLRERYESWRRTQADEVIERAYGQIDLDKKLRQIRVEVSKDRRIGIVLDRLTAEQCRRDLLRLLQKEIADELQLPTFDEWLRDNGQGVLFGD
>NC_018014.1|WP_014786607.1|3770430_3771129_-|ParA-family-protein
MPVIAVSNPKGGAGKSTTTLLLASYLAQKGASVCILDADPNQPIHDWKTQGTSTTKLVVVGGVRESNLMEILDAQKQQFIFIDLEGTASVLVSRSIALADFVIIPVQASAVDVRQASKAIRAVRDEERVAQRSNPERRIPFKVLMTRTPAPGAPVSSVQQQLEKEISAAGIPRFKNSLAERLAFKAIFVERLSLPELHSHRVGNLEAAYENVHLVVEELIETLARLQKEETE
>NC_018014.1|WP_014786606.1|3769458_3770007_+|hypothetical-protein
MARPVKWSRDLYPIRERAAHSRTETWARKDIERLFDIRRASAQSLMKAIGEVQAVGGAHFVDRTSLLAFLDEMIAADLVENALRHRLLEAEAPPAPKPLRVALPAGLRNVMLRDLPENIKLTTGRLEISAPDTIGMLENLALLAQALQNDLLSIEMVLDRPVASRTTDPDLGAFLERLRLVD
>NC_018014.1|WP_014786605.1|3768396_3769335_-|site-specific-integrase
MTESTEIALWAPEEPETASPAPGLSPAQLQLRQMVLDAVTSPHSRRNYAKALDLLFAFAPSRPLTRALLLEYRTSMEDLAPSTVNVRLAAVRKLVAEARKNGMLSHEDAANLTDIPNVKEKGTRLGNWLTKEQARELLAVPDRSTVKGKRDYAVLALLVGCALRRRELASLTVEDIQMRENRWVIIDLVGKGGRVRTVAIPVWVTKGIDAWQAAGSVEKGPLLRSVSKGGKVGESLSDWAIWSVVTEAAKEIGIERFGAHDLRRTCAKLCRKAGGDLEQIKFLLGHSSIQTTERYLGSEQDIAVAVNDAIGL
>NC_018014.1|WP_014786604.1|3766635_3768321_-|hypothetical-protein
MADPETIAGKMEYLLPGSSKENQVPFWPPDVFCLCAAILQNSGAYSRVLEDNEKMLLGEDSDARAEKLRSLGKAWTEAKTREALPNEIGRLWGEIYSEREAELNRLGTPELSRCRSALLDLLALADEASVGLGINSRRHQDGDGTIFKAEADRTFVKSMTGQEGGSLCKEIHPSRARVLPKMHTPQSGLTIRSLSHHLGYCPGSDMQPYWYDLTPSVPTHCVNLLLIPWPMAVEPSQFASTKTKRIDEKVGPGGYGLFTYKPGRGPTVEYVRSLLSEARRKVGPIGGIVFPELAMSEAEFDQIARVFATPDTFVVAGVGEAAGVKAGKNKAMLEVVNPDIIDKSGDPVHVRIVQKKHHRWKLDKPQIVQYGLGANLHPLANWWENIELGDRQITFVALQSWLTMSVLICEDLARPDPVGDIVRAVGPNLIIALLCDGPQIGNRWPGRYASGFADDPGSSVLTFTNLGMSKLSRASDPSKDRSGVVALWRDAKTGTTELSCPSGSEAIVLNVTAEYHEEWTADGRGDGKSGGYPVLSGFHPIKRPDSSSDGWFGWFQRRKQR
>NC_018014.1|WP_014786602.1|3764496_3766032_+|SAVED-domain-containing-protein
MTQAVSVRREGDTYQARVFWQNAIQMLDPQSSIQRVGFEFGPKSFDDVWVEHAGGATPIDHEGKPLLRDHIQSKWHVGPGQYGFRDIIDPDFINATSLSFLERARAAQLLHAPDGTGSRFRLITTHRIDCTDALCGLIHGRAHNLRLDKMWEGKTAKSATGELRSVWAKHLGITDKALRVLARTLAFTETTESLDVFRQNLAERMGWHGLKVIPASESAFIYDEIVFRWLAQGRNVFSRADFYAACKHEGLLASIKPAPVVFGVKSFEHATDPLEPRCVKTLNLLPDFYERQIRPESDWTSVIYPKLKHFLLEAAKDHASLRLALDAHITLGVAAGSILNVKSGRTIELEQRTNGRQVWSPTDTELDPSWGVWQAVQETKDPGESDLVLSVGLSTDPWPMVDAYLKRAEMTYIHRLSLTPSTGTGAASVRSGRHAIALADDLVHRVSLLRANGSFTGRVHLFMAVPNGFSFFLGQRISRLGRLTVYEYDFEGLKSNSYEPSLHFPVPAIAQ
>NC_018014.1|WP_014786601.1|3763564_3764500_+|AAA-family-ATPase
MKTSLDALFDRRLSYPDMGAAKRLSQLVGLDQTKASLTKTLGILVNTSGPQEWAKKFHGQADALLSYVARRPPLVIFAGDVGTGKTELAESIGDSVARQEGIDITLFPLSLATRGSGRVGEMTQLLSEAFDAVADHARQLKGRGKKAHGAAILFVDEGDALTQSRENAQMHHEDRAGVNAFIRGVDRLAEENLPAVVILSTNRLNSIDPAVQRRAADIVTFRRPNDEQREAVLQKPLEELGFSPKDILEVVKHTGPRKPGEEGFTFSDLTQRLLPAIFLDAYPNQAVTHARTLQIVAGIAPTPPFSQGVAR
>NC_018014.1|WP_014786600.1|3763043_3763562_+|hypothetical-protein
MGSYSVTATVAFTITHARYIASKVATDLKRLQGLYLTYDPSDSEIDSYEEELTYLLKHDAVSSVVYGYKRNGAWTAACVRYTVAADGSMQTDDDPGKIRPGHDIAGATFTSFLSYSSSWWQKSEEERERIKKGSPLTRSSQSTPGLERGYWSDDLSYSAGGRGVARSTVKGS
>NC_018014.1|WP_014786599.1|3762065_3763031_+|nucleotidyltransferase
MSREHVTHRDIVQFAEERVNLKRDDALELRRQANLLRDRLQTYLADHPDFELRKMLLSGSLAKGTALKSVSDIDVACYVSSDTAPHKVSDLIAWLASRLEKAFPNFKPEQIQRKTYSVAVNFITTGNEVDIVPILYKGDPQWKGSLISQDTGEELMTSVPMHLEFLRKRKDANKTHFAQVVRLIKFWAKLQKQADENFRFKSFMTELIVAHLADNGMALNDYPTALSRFFNFLACDGLKSTITFSDYYKTSDCEVTSDPIRIWDPVNCQNNVAKLYKESNRDLLIEAALDAGDAVEAALRATTKGETVRYWQKVFGPTFSA
>NC_018014.1|WP_014786598.1|3761755_3761962_-|transcriptional-regulator
MSDKRTMTLNLSEAEMTALEELCVKKDLSKTAVLRQALRLYQTIDARVDQGHKLMLEGTHEKSELMLL
>NC_018014.1|WP_014786609.1|3773852_3774089_-|hypothetical-protein
MDLRSWREADKSEHVELFTEDSDVLVIYWLATARELASRQDAWEKGWSRFADAAESECMRRGLPIAELSKQKGLVLLS
>NC_018014.1|WP_014786612.1|3775052_3775463_+|hypothetical-protein
MTTPRNSGSAPENASDKPGFRTKILSTRMTPEELREVEAAAERDGKKSAEWLRDTALRSARQRPADPMEVLLGEQSAMRYMLLNLFYATAQANAEGKHLLPESVLKIRDQANARKVTDMRKLLESFAQEGGVGGQP
>NC_018014.1|WP_157178391.1|3775612_3777427_+|type-IV-secretion-system-DNA-binding-domain-containing-protein
MASSFAEDHPRNLTSIRWVMKTAPKRKPEVLLPADSEADPDSKLAVKLSAVARVRGWQGIVQDPVEKVRSAELAPYLRSQIFEGESAGWLIARPLLYSLAAMIALYTAWQYFRHGSGRARAHEERHGRRTKGPELGSGLARFRRSGEDGIRLRMQRRGMLPGGSYRIPKRLESSHILLMGDTGSGKSSAIRQILRQVQERGESAIVYDPAMDFVGEFYNPERGDLILNPLDARCPWWDLRGEVSSPEIAMTIAAAMLPEKEYEKAFFTDAPRRVLARLLMWHPKTRDLLQWMSDPEEIEMRVKGTPQAALVDPAAPAQRAGVLSSLNMIADSLELLPEDHTKPGFRTEDWKFQRTRWVFLTSSAAYREKLLPLHSVWLDLFILRMMEPCVNEGAKPVWFVLDELASLNKLPQLHAAVTENRKYGNPVVMGLQGKSQMEKRYGQDAEAMLSQPATKIFLKTSEPRAAKWVSDAIGEIEIERLKESRSMELLGSKQSYAMEIATKPLVMASEIAGLAPLHGFIKQENRVIPTNFALAKKCNKQADFVERKREEAPPTKPAEKLTDAPIQKRVPAPTSKQLQAELPLGKPPEVKREGFTWDSSNEIE
>NC_018014.1|WP_014786614.1|3777475_3778447_-|tyrosine-type-recombinase/integrase
MRLEQAISAYIEQKRAGGAAFAKGAQILRSFSRHVRNMDLQDISERQITNFLNGPQTSTVTWRSKHLLLKHFFLYWRARGEVAGLPLPPSRAPVPQVFTPYIYSRSEVRQLLQATRVSQRDKACKFDAGTFRAFLLFLYGTGALTGEARRLKRCDLDLRRRRVTIRGSQFGRFRVLPIGTDLYGILRTYINSRQRRGTSSEHFFSDVDGHALNETTLAKSFQRLRRIAQVVRRDGYPYAPRLHDFRHTFAVHRLSSWFKRKADINRMIPALSAYMGLVGLGSTERYLTMTSERFRTQLDKLSPKRSKKHWRDDAALMQFIEGL
>NC_018014.1|WP_157178392.1|3778446_3779325_-|tyrosine-type-recombinase/integrase
MAALFAVDLRYRGLSTATVTGYSSRADMFLRWLASEINDFGAVSIHHVDQFIAVKRTEGWKPRGVATQCQALRSFFRFCEMRGWCDSGIPLGIRSPRIPKYENVPKAPSWPQVQKMVRSIRGLDPVSLRSKAILTLLTIYGLRSSEVTGLRLDDFDWRSETFTVRRAKRGGIQHYPIQYEAGEAILDYLQRGRPKCESRLLFVSARRPYGRLSQSPMYHTVDVAMRKVGINLEHTGPHALRHACATRLLQKGSSLKEIADFLGHKDIKCVGIYARFDLQLMRKVANVSLAGL
>NC_018014.1|WP_014786616.1|3779760_3781635_-|radical-SAM-protein
MSLISRFANASWTVLNSVGRKDGQLPTPSWSTSRLLKRTERHFPPLGPRFTQSVCPACQLETRDAIIRGRGKSSSLFADEALIEAEVVEVNGQVVMRKYCARHGQIEDVLARDASFFWRMEKLFPGCDFPRRENADSLGSHTVQYGRGSFLIIDLTTRCNMKCEPCFMNANEIGHVHELSLSDIRKQLDYALTVEPRREINILFSGGEPTISAHFLEAVAYAKSIGLHRLHAATNGLRFAEDPSFAIAAKGAGLHGVYLQLDGVTNDTNVHRGIGNLFDLKVKALDNISAAGLHTTLQVTVINGVNNARLAEIVEFAAKRSDQILGVVFQPVMFTGRDEQITETRRKQQRYTLSDLSDDLSQQSGIVWMPGRDWFPMATYNTLAILLDTLNPHRAMGSTCVNAHPDASVVSPLIVNRTTGEPTPLASFFNVERFLNDMEAVLERGRGALMSKASILASLRRNFEQRLAPINFRFTDLLQLASRSAARFDSSSEERIYSQDKWSLLIASGMWFQDLFNYELPNIQLSTALVADLGVEGLSPSEISFSFKNAVGWRQIVENHASVPTLSDWHRSQGRHAIYANGVSVTVDELTSSLKRCFAEEPSSGGYILERFSRPEVNGEPSLR
>NC_018014.1|WP_014786618.1|3782027_3784784_+|relaxase-domain-containing-protein
MLTMSSKALSAGQARTYHAREFASERQNYWSRDQQGFSEWQGRLAENWGLSGSVGNEHFARLSEGQHPITEQQLVKHQVSRTYEGKGGREVTSVEHRAGWDATFSAPKSVSLTSLVGGDDRVREAHRESVRVALREIEHYTQARIGNVHAPETTGKFAAATFEHDTARPVEGYAAPQLHTHAVIFNVTERENGQTRSVQSHELYASQHYGTAIYRAELATRLQDLGYEIERGKDGQPEIKGYTREYLEASSPRRQQVQDYKREQGIDGAAAGQIAAHRTRDKKELQTPTEVQRAHQEIAAQHGHQADRVVAEALERTHKVRQEQAYSPEMKAQQAVTYARDHLFERQAVQDRRALYETALDRGMGEITHSQVRQEFERRMQAGEFREAPADVRGPQITTAEMVRMEREIVSVMRQGNERNFSHPMLLEGRERFDTIDRHPELNASQRTTAEELFASREKIVAIDGVAGAGKTTTLAVVREGAEAEGYRVEGFAPTSRAAQKLGEAGIETSTLQMHLARGQKPDSGEKRLYVLDESSLASTKQMHEFVTRLHRNDRVLLVGDRRQHEAVDAGKPFAQLQQAGMRTISLDQIVRQKDPELRNVIEQLSRGEVGAAVKKLDDQGRVHEFRGREERMNAIAKEYAKSPENTLVVSPDNRSRAEINGRIRAELQEQGLVSREEHRIQTLVPRQDLTGAARTWAEKYEVGDVLRYSRASKETGIDKGEYAHVLDVDGKQNRITVELNDRRQQSYDPRRQSGVSVYREEERAFSSGDRIQFTAPANDLKVANRELGTVEGITEGRMALRMDDGRFVQIDPVKHPHLDHGYAVTSHSSQGQTAERVLVHVDTELGAKDLLNNRMAYVAVSRGAHDAQLFTNDREKLPIALGHEVSQQSAHVPDMAKEQRVEIAPKHEHSYGFGISV
>NC_018014.1|WP_157178393.1|3785378_3785681_+|hypothetical-protein
MKSAVDIAKDFTELVLNSIRLDETNPMKPKKQDLLTLSVRLPRTEKHRFERLARRYGVEQTQVVRKAVTAILDHLEDQERQIQQLPRHAQAPLFSESAGK
>NC_018014.1|WP_014786620.1|3785816_3787328_-|ATP-dependent-helicase
MLESGTSTVQPVIAQQRAVDLFLAGGNLRIDAYAGTGKTTTLRLLAGSKPGRGLYLAFNRAIAVEAQQRFPSHVKCATTHSVAYRGVRRKLGYPQWKLTESLTPNLILEAFRLPQTVSFHSGVVLEQRSYAAILRDGMKAFLQSSDKAPGSAHIPRYGMLETLSSGQFDSFATQAAEHLSYLWMAMLDRERGLPLGHDGYLKLWALSEPRAEVDYIMVDEAQDLSPVLLDVLNQSACQIVYVGDPYQQIYEWRGAVNAMQQVHTQHRCLLSQSFRFGPAIAAAASIVLRTLGARESLRGSAAIDSHIGRVRPDAILARSNAGVIANVLRCLAQNLRCAVSGGTKELERVLSDVQRVKQGQVAQSPELLGFQNWRDVMSFSAQPEGGGLRPLVNLVQEHGEARMLRALSVCESSEATAQVICSTAHRSKGREWNYVHLDRDFEAGFVRATQLPPAEVSRATASEARLLYVALTRAKLGVHLPRETAKRFGIRSTTNELLGRSAG
>NC_018014.1|WP_014786621.1|3787851_3788064_+|hypothetical-protein
MHSQHDVGCKRSLELDMFTRSYATFGRQNNEYRVVLERNRGVVLGGRRGVSSWWAMLATAHRQPQAWVVP

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Crispr_ID: NC_018014_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_9

4025654-4025875

Orphan

Consensus_repeat	Method
CACATAGGCGGCTAAGTGGTGCACCGCATCCCCCCTGCCGTAGCGAACAATGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018014_9

>merge|NC_018014|9|4025654-4025875|CRISPRCasFinder
CACATCGGCGGGTAAGTGGGGCACCGCATCACCCCTGCCGTAGCGAACAATGGTTCACATAGGCGGCTAAGTGGTGCACCGCATCCCCCCTGCCGTAGCGAACAATGGTGCACATCGGCGGCTGATCGGAGCCCGTTCCGATCCTTCCGGCCGTCGCGATCCATGGTCCACATAGGCGGCTAAGTGGGGCACCGCATCCCCCCTGCCGTAGCGAACAATGGT

>NC_018014|9|8|4025654-4025875|CRISPRCasFinder
CACATCGGCGGGTAAGTGGGGCACCGCATCACCCCTGCCGTAGCGAACAATGGT	TCACATAGGCGGCTAAGTGGTGCACCGCATCCCCCCTGCCGTAGCGAACAATGGTGCACATCGGCGGCTGATCGGAGCCCGTTCCGATCCTTCCGGCCGTCGCGATCCATGGTC
CACATAGGCGGCTAAGTGGGGCACCGCATCCCCCCTGCCGTAGCGAACAATGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_157178415.1\|4027255_4028287_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786838.1\|4028480_4029329_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381314
NC_018014.1\|WP_014786841.1\|4034435_4035620_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|379862
NC_018014.1\|WP_041593422.1\|4023505_4023685_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786844.1\|4038366_4039737_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NC_018014.1\|WP_157178671.1\|4022072_4022642_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786845.1\|4039777_4040635_-\|spore-coat-U-domain-containing-protein	unknown	unknown	gnl\|CDD\|227717
NC_018014.1\|WP_014786827.1\|4019095_4019290_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786840.1\|4031283_4034433_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226220
NC_018014.1\|WP_157178670.1\|4018055_4018961_-\|segregation/condensation-protein-A	unknown	unknown	gnl\|CDD\|234635
NC_018014.1\|WP_157178416.1\|4029642_4031127_-\|TonB-family-protein	unknown	unknown	gnl\|CDD\|367555
NC_018014.1\|WP_014786825.1\|4016033_4017608_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379971
NC_018014.1\|WP_157178417.1\|4035619_4037161_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NC_018014.1\|WP_014786831.1\|4022776_4023505_-\|SIMPL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225516
NC_018014.1\|WP_014786833.1\|4023759_4024035_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786836.1\|4026162_4027338_+\|sensor-domain-containing-diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_018014.1\|WP_014786828.1\|4019321_4020881_-\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|183401
NC_018014.1\|WP_157178418.1\|4037224_4038370_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|236901
NC_018014.1\|WP_014786834.1\|4024117_4024405_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786829.1\|4021333_4022038_-\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|100079

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_014786838.1\|4028480_4029329_+\|aldo/keto-reductase	gnl\|CDD\|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	1.53776e-148
NC_018014.1\|WP_014786841.1\|4034435_4035620_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|379862	pfam16576, HlyD_D23, Barrel-sandwich domain of CusB or HlyD membrane-fusion. HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.	3.98248e-60
NC_018014.1\|WP_014786831.1\|4022776_4023505_-\|SIMPL-domain-containing-protein	gnl\|CDD\|225516	COG2968, COG2968, Uncharacterized conserved protein [Function unknown].	1.37202e-18
NC_018014.1\|WP_014786844.1\|4038366_4039737_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NC_018014.1\|WP_014786840.1\|4031283_4034433_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|226220	COG3696, COG3696, Putative silver efflux pump [Inorganic ion transport and metabolism].	0
NC_018014.1\|WP_157178417.1\|4035619_4037161_-\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	4.36445e-39
NC_018014.1\|WP_157178670.1\|4018055_4018961_-\|segregation/condensation-protein-A	gnl\|CDD\|234635	PRK00104, scpA, segregation and condensation protein A; Reviewed.	9.93455e-53
NC_018014.1\|WP_014786825.1\|4016033_4017608_+\|hypothetical-protein	gnl\|CDD\|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	5.29646e-08
NC_018014.1\|WP_157178416.1\|4029642_4031127_-\|TonB-family-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	3.9583e-15
NC_018014.1\|WP_014786845.1\|4039777_4040635_-\|spore-coat-U-domain-containing-protein	gnl\|CDD\|227717	COG5430, COG5430, Uncharacterized secreted protein [Function unknown].	1.4249e-23
NC_018014.1\|WP_014786836.1\|4026162_4027338_+\|sensor-domain-containing-diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.11053e-44
NC_018014.1\|WP_014786828.1\|4019321_4020881_-\|tryptophan--tRNA-ligase	gnl\|CDD\|183401	PRK12283, PRK12283, tryptophanyl-tRNA synthetase; Reviewed.	3.53021e-171
NC_018014.1\|WP_157178418.1\|4037224_4038370_+\|sensor-histidine-kinase	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	8.54338e-61
NC_018014.1\|WP_014786829.1\|4021333_4022038_-\|site-2-protease-family-protein	gnl\|CDD\|100079	cd06158, S2P-M50_like_1, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with a minimal core protein and no PDZ domains.	4.01484e-50

>NC_018014.1|WP_014786834.1|4024117_4024405_+|hypothetical-protein
MSHAPVLISERHLTPAEVEIVDRRRRRGQLLLTIGFQAGIITTLVGVLWVGQDLTQSPGMVHPMFYWACITGTISVVCLLAGMSMRRGFHEFTSY
>NC_018014.1|WP_014786833.1|4023759_4024035_+|hypothetical-protein
MEERDFFDERTEPRTMTLTCTKCGVAGEYALNWIVRRKKKQLNGRADERDRARFAKAVNYMVLRDDTANCTNPRCRKRFEIAGIKTMAFID
>NC_018014.1|WP_041593422.1|4023505_4023685_-|hypothetical-protein
MSKAKKEVFSVTKAVKANARERVGSPPPEVVIPDDKTRAARRTSKHKVTLQKLMQREES
>NC_018014.1|WP_014786831.1|4022776_4023505_-|SIMPL-domain-containing-protein
MKKVWLAAVFAAVTSVGAQAQVAQTLGINKDNRSITVTATDSAFAMADQAVVNIGYQAYGEDEQTAYAEGSRRSNAIVDALTAAKVPAEAIESQDQQLQPLNEYELKNLPASLKNMKFRITQSWSVRSTPEAAAKTLDVAVKAGANQSGSIGWEMKDGSMLEAAASAKALAHAQSIASRMAEGLHIKIGSLLYASNQAQEIARPMPMMAMAARAKTADAKPLSISARRVERSATVFAIFAIE
>NC_018014.1|WP_157178671.1|4022072_4022642_-|hypothetical-protein
MQEAPAETQLHPEVPRPLPEAEAIYRRWLAHLNAEFTRYNSCTRRSEIVRDELHSLLLGRPHGGRMNAALISELPLAVLAESLDPRNVTLPAEMEVDLDREKFNTIKPLLWFWRGFDRTVLGANLWLGLRFRAMLGAHIFAGLGKNVRFYRDVNFERGYTLTFADNTIVRPGACIDDRQPRIISGTLER
>NC_018014.1|WP_014786829.1|4021333_4022038_-|site-2-protease-family-protein
MNQEVALILFEFAALVFALTFHEFAHAWTASFFGDQTARMMGRVTLNPIKHLDPLGSVVLPLVSAFAHFPLLGWAKPTPVTTRNLRNVKRDDILVTLAGPASNVLLAVASLVLLLVIKHVFPTGQMAVLNAALLSARIEGATLQGQGAIFPISLLLYSSVVINLLLAIFNLLPVPPLDGSRILRHYLPYNALQMYDNIGGFANLIILYLLMRSGVLNIFFGPAFSLFNRLLLSA
>NC_018014.1|WP_014786828.1|4019321_4020881_-|tryptophan--tRNA-ligase
MSELQAKRRVLSGMRPTGRLHLGNYMGALYNWVRLQDQYDCFFFIADLHALTTDYADPSRVRQNTMEIALDFLSAGLDPEKSTIFVQSQVPQHAELHLIFSMFTPLGWLERVPTYKDQLEQLKAKDLNTYGFLGYPLLQSADILLYKPDFVPVGQDQIAHVELTREVARRFNQLYGGDGFGGKQALNEAPVSQLLPEPNVLLTPSPKLPGTDGRKMSKSYGNFISMSDPPLIVLQKTSGMSTNGQRISQSDPGDPDLCPVGDLHKVFSPEYTQTHFFHGCRTATVECRDCKMGCGNAINMVLAPIRKTREVLEQKPDYVADLLSAGAAKARAASEETMRIVRDAVGYGGDLHGVRISAPAYLSSAAPTAHDLREHEDWWTIEEDNLRSRLIREWWFKEVLPTDITLREDSPRVYVTKHNKRVYVTTSRADKSGSYDFEAKPKSYDLLCLMCWDVDRMMRIFVVPQKLYVQEWTAAKKQAGKEMMKFFVLQEEDHFFLRIAPSQAQVDITEYLSSYDLLD
>NC_018014.1|WP_014786827.1|4019095_4019290_-|hypothetical-protein
MSGLTDEKPVPNQPTPAPAMDADRAAHSNLAPQGTVDLSDQVPNSNFTPEGDQEDVPNIAATAE
>NC_018014.1|WP_157178670.1|4018055_4018961_-|segregation/condensation-protein-A
MAEVSAAEPQGPVAEPLVLQSPPTPEPVKQPKKREPAPPKEEASQSPFLLTVGAVYDGPLDLLLDLIRRQSIDIYDIPIARLTEQFLAYTETLKQTDVDSAGDFIYTAALLIHIKSKMLLPREASGIAAGDIEDPRRELVERLLEHERFKAAAQMLMQKQQIEDATWTTPGIREFKEQVVAEREIDADTTDLVRVFGEIIERLRKRPVLNVNEETVTVAQMIEYTKRRLMLEDKPTSLRKLLQNTHSQQALICMFLAMLELVRLQAILLRQSDKFGDILIKKTDEFDEVLAHQERMRDDWR
>NC_018014.1|WP_014786825.1|4016033_4017608_+|hypothetical-protein
MNRRDFLAASAAVLATVRDSSAFAASEPLFRTGNARWQSTYDAALRVLAGNIQVMPRFPGPVLIEGSSYAGIWMECGPHEALLYRSFRPDAARNSHLTFFALQKEDGQLPANNKATAASPGWAQIQMVVPIAATAWELARTTGDHELLEKAYIACSRWDDWLMRHRNTRGTGLVEGFCTYDTGMDNSPRWHGMPNACPDGSARNLPRVASLPRLCPDLSATTYGARVALAAMAQALGKASEASMWQQKAATIRQLILDKLYVAEDTAFYDLDAQNNFVKINCDILSRVCSEHVPDQRLFDTLWQRQIHRPQGFWPQFPLPSSAIDEPTFVRPIPRNSWGGASQALTAMRAPRWMDHYGRSADFAHMMDQWCEALQRDSTFRQGIDPLTGTFSPDEAPKYSPAALVMTTYTWRLAGTHDEGDEIWWNIRAGHPAAQDATFRMKTDNGKIAEMHYTGKAATLSLNGKQIATIASEGTRLITTKDGTPKALVGINNRSATTNVSLHISGKATSQRSLQADEHMNLKP
>NC_018014.1|WP_014786836.1|4026162_4027338_+|sensor-domain-containing-diguanylate-cyclase
MARKSQKHLELEFTHAIQQDYTRLFHDVARALTSTLELEIVLTTVMTKMAQFFGPERWSMMLVDKEKNDLYYVIAVGEDSKSLRGLRVPMGEGVAGWVALTGNPMVVPDTSVEPRWQEFSRKNPGLNINSIACVPVRSADGVVGVIQLLNSKVDLLSDYSIQFLRVLCDFTAIAVRNAADMERIHLLSISDDCTGLFNARHLYTLLEERLKTQERAPFSLLFLDLDHFKSINDTHGHLVGSRLLAEVGDLIKRTIGPTIPAFRYGGDEFVCLLPDLGKSAGREVATKLFYALREARFLEVEGLSLELRGSFGMATYPDDARDIEGIIKAADDMMYYVKGTTRDNLAIAGLGSVLSPGTIEGEEGARAGNVVEPALGRDELLARSRHDSVRH
>NC_018014.1|WP_157178415.1|4027255_4028287_-|hypothetical-protein
MFLSRVVLVGGLVMAVCVPLVAQERPSLPLEASPGSGLRRTRLYLRDGSFQVVLSYSVKGENVFYLSAERGAEQEIIPVKLVDLDKTREWERRGEAQRNGTPAVQIDPELAKEEADRAARSPEVAKDLRLPDESSVLMLDTYQGQPQLAVLQQTDGELNRQQAHNILRQTINPMAHAHQLVEIKGQTAPVQLHVADPEIYVRMDDDDAEPTRGGAFQVDTDGNRGRKVESPSPKSEYVIVRVDVRRDVRIVTSFSIGLLGGAKRQADVVETTRTLMPGGHWLKIVPKEPLSFGEYALMEVIDAKTVNTGVWDFGVRPSAGPNRDAILPEVRHAPKLAPRRSQP
>NC_018014.1|WP_014786838.1|4028480_4029329_+|aldo/keto-reductase
MSIQRTFKLGGDLEVNRLGYGAMRITGEGVWGPPKDREGALKVLKRAVEIGVNFIDTADSYGPYVSEELIAESLAPYQAGVVIATKGGLCRVGPNKWLPVGRPEYLEQEALMSMRRLKTDVIDLWQLHRIDPKVPVEESLKPIVKLQKTGKIKHIGLSEVTPAEIEQARKVADIVSVQNEYNIGQRKSEATLEYCEKNNIAFIPWFPVAAGKLAKEGGPLDTAAKQHNATVSQLSLAWLLHRSPVILPIPGTTSIEHLEENFKSLDLELSDAEWQSLEAAAK
>NC_018014.1|WP_157178416.1|4029642_4031127_-|TonB-family-protein
MQPAQLKDVSVRYSHEVAELRDFLGKAGFSLGTAGTLEAVAAALQRDRAFHRDLILHVWVLIDGCGGQISPSDLLGVLAVAAAGMHFAAEASEEDAHDLLRFVMEARRSVDAPTSKRVAEPVPAAVVSAAVPVAAAVDVPAAALPLALDTPRFTPPVAVDEAPSEEVVERGGGKRSAWIVGLALCLLVLVAVGVWQYRENSPAPVEVGTAVDGSAATAVSPSTAEAPTSGNGLESAPVVPTPVGPSMTARGPVVRPSREAAAVDRSVVPSVPPRTSYAPPAQDVAAAPAPVVRSAPPASPVATVTPLTRPAVAAPSTPLVRPGAARPAAPVAVPAGTLSRQLGSSTIPAYAALPDADATTDGKKYPRLLRRRMSLNNNTQVAELRPPGGSGGAGSVPVGVVRPTSLGIMAGNLVYSPTPAYPSAAAAAHVQGEVKVQAEIDRDGNVVSARVVSGPPMLRDAAVDAIQHWRYKPWTAGGKTVPMSAVAVVDFQLP
>NC_018014.1|WP_014786840.1|4031283_4034433_-|efflux-RND-transporter-permease-subunit
MLQAIIAGALRQRLILVVVSLVLVGFGLNAAKHLSVDAFPDVANVQVQIATEAAGKSPEEVERFVTVPIEIAMTGLPGMTDMRSLNKPGLSLITLVFADGSDLHLQRQMVSERLSEVRDRMPEGVAPVLGPITNALGEVYQYTLERAGEADEKHVLSTDELVERRTLQDWVVRPLLRSIPGVAEINSTGGFVKQYETLVDPQKLHYYNLTVNDVRNSLAHNNANAGGGILPQHAEQYLIRSVGLVRDLEDIRNIVLKESRGTPVYIRDVAEVRLGTEVRYGAMIKNGYTEAVGGVVLMTIGGNAKDIVSRVKERVDEINARHMIPGGLRIVPYYDRSQLVDAAIHTVTEVLGEGILFVIVVLVLFLGDIRSSLIVSATLVVTPLLTFLIMNQVGLSANLMSLGGLAIAIGLMVDGSVVVVENVFAKLSHARQHAAEAIGSRQKLNIVLAAVTEVATPVLFGVTIIILVFMPLMTLEGMEGKMFAPLAYTIAIALAISLVLSLTLSPVLSSYLLKGGSEDDTRLVRILRRPYNAMLGWTLANRKKAVVAVVIVFLGAVSLFPFLGTAFIPEMQEGTLSPNADRVPNISLEESLKMEMSMQKSMMTVKGVENVVSRVGRGESPADPAGPNEADVLASLTPYDERPRGRSQDKIADEMREKLASIPGINLVMSQPISDRVDEMVSGVRADVAVMLYGDDLDVLVAKANAIAKVASGIQGTQDTRVDRVGGQQYLTIDINRAAIARYGINAADVNEIIETAIAGKSATEIYEGERRFQAVVRLPHAQRDSMEDIRQLLISSPDGPRIPLKELATVKVAEGPALINRSMGKRRIVVGVNVANRDLGGFVAELQQKVDQQVKLPAGYFIEWGGQFHNMERALHHLMIIVPITIAAIFFLLFVLFKSVRFAALIITVLPLASIGGVLGLFLSGEYLSVPASVGFIALWGIAVLNGVVLVSYIRKLRQEGMGQDEAVREGTRLRFRPVMMTATVAALGLVPFLFATGPGSEIQRPLAIVVIGGLVSSTALTLLLVPAVYAFFEGKAEYVIDEADEWS
>NC_018014.1|WP_014786841.1|4034435_4035620_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MFPAFRFILPPFRVTLVTVLAATSVLSFEGCKKETKAEVAAAQTDPLAVKVPPALRGSLKLGAPHLTDVSGTLQVSGRVETDASRIARVGSPVAGRILKLNAFEGQNVRAGTVLAMLHSTNLSDTQLSLIKAYSTETLAQAATKRAEQLVEADVIGRAELERRRAELVQASAEVSSYETQLRGLGMTSQQLKTLQSTRRLSADYPIVTPRGGTVLERKVTVGQVIQPADPAYTIADLSSVWIVANVPEEEAAMLHKGLEVSVRIPARPEQSIRGALSYVAPTVDPATRTVEVRMDLANTQGLFKPDELASVTFNGHTERKLTIPQTAIVREENKDYIFVKTSADNFLLREVELGDESKDERVVLSGVNASETVVLDGAFHLNNQRKQDAIKGSH
>NC_018014.1|WP_157178417.1|4035619_4037161_-|TolC-family-protein
MLHRLTLVAIGTPNITVAVPERSGFAGCSICVRFARQGCPIRDIYRESAVICGSFCWPPDCTSKVVKPFAVIPIAALLWVTATSGQTVSSPAAGALSLPPSAVSQSPAALPAAPEAQPSAAKPLTLEQAIAMAEQNSPRLRGAAAATQRAAAAVGTSRAYINPSLEVFQGRQYARPIATPGVPGLLQHYAAYQAIEIPSERRARTRAAELSRLSADFGQKGVTRSVVADVKHAFYDVLRRREELAHQQENLKLVEDLRRRVEVEYRVGEKGRLELTRAEAELGRAGFAVRGAQLELANAIALLRIAIAAPADDALDPRGSLEQRIKLPELTALREEVLRTHPAIAQAAAEVDAAGARLDRERRLRIPQPTAFAEFENQPDLRFWRAGVTVPIPLWDRRRGPIEESKAAINQAQAEAGQRRLELISATERAYEQYQLADQQATSLESGELRAASSAVDAAQAAYRFGERGIVEVLDAQRVLQSVRDDLINAQFARQSALIDLEELGAIVPGGRP
>NC_018014.1|WP_157178418.1|4037224_4038370_+|sensor-histidine-kinase
MESVQSRIRSPRFITAMIAFLIVSLAITTWITPPHAVVLHNILHHLNILPFMLAGMIFGWKGALRAIVFAVMLQAPIVYEHWYRAPLDAQDQVVELSTFGIAGMIAGLVADRERMQRARVEATKHELERVYSELRENIQQMKKTERLTAAGELAASLAHEIRNPLASISGAAGIVARGQAPAASQHECLDILMKESQRLNKLLTNFLDFARPRLPRFQATDPGAMLQSVTTLAQHSGVERGVDIVLRTNSLRGEVQCDAEQVKQVLLNLMLNAIQATSGHGTILVRAFMNAQSLCVEVQDEGCGVEQQNMDRLFDPFFTTKENGTGLGLAVSANIVAQHGGTLSCDRNGADRRGMTFRVELPLQPPSVGDAARAKDKAAFA
>NC_018014.1|WP_014786844.1|4038366_4039737_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MKKGTILVVDDDSSLRRVMKIQLEEAGYSVALAADGDEAYDILPDLRPALVITDLRMPSGGLDLLRKIAKSDMDTTVIVITAFGTVETAVEAMKIGAYDYVTKPLDFDALVLVVHRAMERQSLREEVRTLRSVLNERYGFENIIGRSKGFLRVLDQASRVAPHDTTVLIQGETGTGKELLARAIHNNSGRRARAFVPINCGAIPEDLVESELFGYVRGAFTGAMTNKTGRIEAADGGTLFLDEVGELPLDAQVKLLRVLQEGELAKLGASAPTRVDVRVIGATHRNLAAMVEDGTFREDLYYRLTVVSLRIPALRERREDLPELIDALFKRAKERHGLSHAQLSRPLLQRLISYAWPGNVRQLENVIERLLVLSADDVLTEENLPDDLQATPSAQTTPLQFPLPEEGISLEAVERELIVQALARFSGNQTHAARYLDISRRTLIYRIEKHGLQHED
>NC_018014.1|WP_014786845.1|4039777_4040635_-|spore-coat-U-domain-containing-protein
MRCLPFLCAPFLLSPVALAQRFPCSVSVPAIHLGTYAGNRVASGVTPVSVICPASTPYTIGLRSSAGGPANTVRTMKGVRGAGLRYQLFQDAARSVNWGSEIGTDAVSGVGTGGVQRFNIYPVLMQSQQASQGEYADALTVTVTSNRGISSANVPVIANALGVCIVLSTAMGFGSYTGGAITSTSTISLTCTANVAYDIALNAGTTTGASTSARKMAGPNGGTLGYSLFRDAAFSQNWGSVSGVDTLTGIATGLLQPITVYGKISSGLIAPIGAYSDTITATITY

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Crispr_ID: NC_018014_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_10

4157153-4157217

Orphan

Consensus_repeat	Method
AAAAATCAGATTCTAAAGGAGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018014_10

>merge|NC_018014|10|4157153-4157217|CRISPRCasFinder
AAAAATCAGATTCTAAAGGAGTTGAGTTTTCGGTATGACTGCAAATATTAGATTTGATTGGAGTT

>NC_018014|10|9|4157153-4157217|CRISPRCasFinder
AAAAATCAGATTCTAAAGGAGTT	GAGTTTTCGGTATGACTGC
AAATATTAGATTTGATTGGAGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_014786952.1\|4167021_4168488_+\|3-isopropylmalate-dehydratase-large-subunit	unknown	unknown	gnl\|CDD\|235490
NC_018014.1\|WP_014786939.1\|4151784_4154205_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|380161
NC_018014.1\|WP_014786935.1\|4147106_4147652_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176862
NC_018014.1\|WP_014786942.1\|4156520_4157093_-\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NC_018014.1\|WP_014786945.1\|4159950_4161837_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_018014.1\|WP_014786947.1\|4162704_4163307_-\|porin-family-protein	unknown	unknown	gnl\|CDD\|379226
NC_018014.1\|WP_014786938.1\|4151248_4151785_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379639
NC_018014.1\|WP_014786949.1\|4164460_4165624_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|234864
NC_018014.1\|WP_014786950.1\|4165707_4166808_+\|3-isopropylmalate-dehydrogenase	unknown	unknown	gnl\|CDD\|234832
NC_018014.1\|WP_014786951.1\|4166804_4167008_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786936.1\|4147796_4149686_-\|1-deoxy-D-xylulose-5-phosphate-synthase	unknown	unknown	gnl\|CDD\|235470
NC_018014.1\|WP_157178422.1\|4144148_4146752_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|227115
NC_018014.1\|WP_014786944.1\|4158722_4159847_+\|TonB-family-protein	unknown	unknown	gnl\|CDD\|367555
NC_018014.1\|WP_014786933.1\|4143473_4144142_-\|sel1-repeat-family-protein	unknown	unknown	gnl\|CDD\|276807
NC_018014.1\|WP_014786943.1\|4157362_4158334_-\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|224012
NC_018014.1\|WP_014786941.1\|4156320_4156524_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786937.1\|4149775_4151188_-\|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl\|CDD\|224220
NC_018014.1\|WP_014786940.1\|4154289_4156263_-\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NC_018014.1\|WP_014786946.1\|4162032_4162620_+\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014786948.1\|4163424_4164348_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|177082

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_014786939.1\|4151784_4154205_+\|PAS-domain-S-box-protein	gnl\|CDD\|380161	NF033092, HK_WalK, cell wall metabolism sensor histidine kinase WalK. This model describes WalK as found in Staphylococcus aureus (sp\|Q2G2U4.1\|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.	1.99432e-63
NC_018014.1\|WP_014786935.1\|4147106_4147652_+\|SRPBCC-family-protein	gnl\|CDD\|176862	cd07820, SRPBCC_3, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	1.52923e-29
NC_018014.1\|WP_014786942.1\|4156520_4157093_-\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	1.44884e-29
NC_018014.1\|WP_014786945.1\|4159950_4161837_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000821474
NC_018014.1\|WP_014786947.1\|4162704_4163307_-\|porin-family-protein	gnl\|CDD\|379226	pfam13505, OMP_b-brl, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	1.59142e-09
NC_018014.1\|WP_014786938.1\|4151248_4151785_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	4.04601e-09
NC_018014.1\|WP_014786940.1\|4154289_4156263_-\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NC_018014.1\|WP_014786949.1\|4164460_4165624_+\|2-isopropylmalate-synthase	gnl\|CDD\|234864	PRK00915, PRK00915, 2-isopropylmalate synthase; Validated.	0
NC_018014.1\|WP_014786950.1\|4165707_4166808_+\|3-isopropylmalate-dehydrogenase	gnl\|CDD\|234832	PRK00772, PRK00772, 3-isopropylmalate dehydrogenase; Provisional.	0
NC_018014.1\|WP_014786936.1\|4147796_4149686_-\|1-deoxy-D-xylulose-5-phosphate-synthase	gnl\|CDD\|235470	PRK05444, PRK05444, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional.	0
NC_018014.1\|WP_157178422.1\|4144148_4146752_-\|TonB-dependent-receptor	gnl\|CDD\|227115	COG4774, Fiu, Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism].	1.5968e-178
NC_018014.1\|WP_014786952.1\|4167021_4168488_+\|3-isopropylmalate-dehydratase-large-subunit	gnl\|CDD\|235490	PRK05478, PRK05478, 3-isopropylmalate dehydratase large subunit.	0
NC_018014.1\|WP_014786933.1\|4143473_4144142_-\|sel1-repeat-family-protein	gnl\|CDD\|276807	sd00010, SLR, Sel1-like repeat. Sel1-like repeats (SLRs) share similar alpha-helical conformations with Tetratricopeptide repeats (TPRs), but with different consensus sequence lengths and superhelical topologies. SLRs contain 36 to 44 amino acids and are present in bacteria and eukaryotes but not in archaea. SLR proteins are involved in a variety of functions, and many serve as adaptor proteins for the assembly of macromolecular complexes. The SLR family was named after the Caenorhabditis elegans Sel1 protein which is predicted to fold into 11 SLRs, a transmembrane domain, and an N-terminal signal sequence. The human Sel1L protein contains an additional fibronectin type-II domain and an N-terminal PEST sequence. Its downregulation is associated with the development of breast and pancreatic carcinomas.	1.55657e-31
NC_018014.1\|WP_014786943.1\|4157362_4158334_-\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|224012	COG1087, GalE, UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane].	3.63026e-169
NC_018014.1\|WP_014786937.1\|4149775_4151188_-\|cation:dicarboxylase-symporter-family-transporter	gnl\|CDD\|224220	COG1301, GltP, Na+/H+-dicarboxylate symporters [Energy production and conversion].	1.22541e-111
NC_018014.1\|WP_014786944.1\|4158722_4159847_+\|TonB-family-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	1.29151e-13
NC_018014.1\|WP_014786948.1\|4163424_4164348_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|177082	CHL00180, rbcR, LysR transcriptional regulator; Provisional.	6.0389e-43

>NC_018014.1|WP_014786942.1|4156520_4157093_-|DUF421-domain-containing-protein
MLHDMLHLPVPLLEKILRPIVVYLALIILLRVFGKRELAQLNPFDLVVLLSLSNTVQNAIIGDDNSLTGGLVGALSLLAANWVLNRILFAYPKLNDIVQGEETVLIRDGMLDEKAMRDEILTREELVGVLHKQGIRGLGDVEEATLEPSGTFYVEAKKDSFPRTRHEEILSRIEELMQEVKKLQQSDAAR
>NC_018014.1|WP_014786941.1|4156320_4156524_+|hypothetical-protein
MYGFAVSSLIGVCLGFMFGVGCALAVMYSIYMGGYRAALRDAGRDVKPDRWFEEQAKVDKDPEKRPG
>NC_018014.1|WP_014786940.1|4154289_4156263_-|acetate--CoA-ligase
MVEQHSEASPNSFTSTMREDRLFPPPPEFAARAHIRSRAEYDEMYRRSIDDNEAFWAEQAQALDWFKPFDKVLEWNVPEAKWFVGGKLNLCHNAVDRHALGSRADKTALLWEGEPGEVRSLTYAELHAEVQRFANVLKSLGIAKGDRVAIYMGVCPEIVLAVLACARIGAVHNVVFGGFAAQALADRMNDAQCKLLITQDTSFRRGQDVALKSIADEALDRSPGVEHVLVYQRSGKPVSMKEGRDHWLHEELAKADAECAAEPMDSEDPLYILYTSGTTGKPKGLVHTTGGYGVGTLLTTKYIFDLQDSDVYWCTADVGWVTGHSYVVYGPLLNGATIMLYEGAPNWPECDRFWQIVDRHKVSIFYTAPTAIRAFMKWGTEHVHKHSLASLRMLGTVGEPINPEAWMWYHREIGKKRCPIADTWWQTETGSIMIAPIPGAVPTKPGSATLPFFGIEPEIVTKEGEPVPLGHGGLLVVRKPWPAMARTIFGDAERYKKAYWSEIPGSYFTGDGARRDMDGYFWLMGRVDDVLNISGHRLGTAEIESALVAHPKVAEAAVVGRPDEMKGEGIVVFVSLHDDAEVTPTLKDELKKHVAKEIGALARPDEIRFTPSLPKTRSGKIMRRLLRELAATGDVKGDTTTLEDFSVVAKLKEKDEE
>NC_018014.1|WP_014786939.1|4151784_4154205_+|PAS-domain-S-box-protein
MATTIKHESATRAAVTTISPEQRRLQALDRLEISSLPDPALDEITQLVAQICDVPAAAVSFVERDRVWFKSRVGLPSRTMLRDASPCDETVLGDDVFQIPDAAEDAHYPDGSIPIGTASFRFYAGAPLRTADGQAVGTLCVYDVAPRRLDELEANTLRTLARQVMTRLELNLNHRIADRDARSRQRVESALTVERNFVSAVLDTVGALVVVLDTAGRIVRFNRICETISGFGLNEVVGQTEWDTLVPPEDRDNAIATYTQLRDGLFPFAFENRWRTRDGSIRRIQWTATALLDAQGEVAFLIATGIDVTLQREAEITLRESEARYRLLIEGSLGAVFTHTLDGTLLSINTYGAENLGYTPDDMLNRPLSHFMPAGAQSSFTKYLASIAASGEAQGTFELCHRDGTSHVVAYRNRLIEASTREKYALCFGVDITEKVRAEERLSALTRQSNSILDSVGDGIFGMDLEGLATVCNPAAAQILGYRPDEIPTEILGRDIHALMHHTRPDGSVYPADECPILNSARELRPVRVSTDVFWRKDGTSFPVEYVACPILNNGAATGIVVAFTDTTERHALDRMKDEFVSTVSHELRTPLTSMRASLGLIASGALQSRPDKSKQMLGIAIGNTDRLVNLVNDILELERIGSGKAELHYGDVDADDLLHRAADLLSGTAAKSGIHFTFGEPGVHLWVDSDRILQTVTNLISNAIKFSLPEGEIHLAAFDSAPGEATLEVRDHGRGIPSDKLEHIFGRFQQVDASDARVMGGTGLGLAICRSIVAQHGGRIWAESEIGQGARFLLTLPTKPSSHLR
>NC_018014.1|WP_014786938.1|4151248_4151785_+|nuclear-transport-factor-2-family-protein
MRSLFFGSVMFLMGPIALHAQLDPLSRRAPANNPVTQPTLSPGVMQLLQLDAQFAKETLAGGGKAFSNWFADDALTLNDGKAAVYGKTHIAAEAAWDPKQYQLQWTPTGGQMGPSGDMGFTWGHYDGHSKDRNGNDVTTSGRYITIWKRLPNGTWKVAMDASANEPAAASECCKLPNP
>NC_018014.1|WP_014786937.1|4149775_4151188_-|cation:dicarboxylase-symporter-family-transporter
MSADTLQGNRHRLRYEIAAWTLAAVLLCGGLTCLASAHFLALGVTLRAAGVLVLLVWATFLRRKLTPWIVVGMVAGVELGLDAPAVAIGSHFLSDIFLRLVKTIVAPLILATLVSGIAGHGDLKSVGRMGWKSLLYFEVLTTIALVIGLIAANISKAGVGLAMPAEMIGSVPSAAPMHWQEFLAHVFPENIAKAIAEGQVLQVAVFAAIFGIALAMAPREKAAPVLKLAEGLSEVMFRFTNIVMYMAPLGVAAAMAYTVAKMGPGVLIHLGKLLLVFYGALLAFILFVLLPVALIARLPLRRLLRHVSGPAAIAFATATSEAALPRAMEEMEAFGVPRRILSFVIPAGYSFNLDGSTLYLAMAMVFVAQVANVPLSIGTQIFMMGTLMLASKGVAGVPRAVLVVLLATAGTLRLPSEPILILVGIDALMDMGRTAINVVGNCLASAVIARWEGALNTETVEPAVLAAMAE
>NC_018014.1|WP_014786936.1|4147796_4149686_-|1-deoxy-D-xylulose-5-phosphate-synthase
MSKFLPTIESPADIKKLTIPQLAELAEEIRERLIQSVAKTGGHIGPNLGVVELTIAMHYVFDTPQDSFVFDVSHQSYVHKLLTGRESRFETIRQPDGLNGFMLRTESEHDSFGAGHAGTALSAALGMAVARDLSGGTEHIVALAGDAAFTCGISYEALNNIAGQTKRMIIVLNDNEWSIDKNVGAIASYFHTIITHPRFTYLHDRASELIERIGGKAAKHVQRKAEESVKGLLGPSMLFEEFGLDYYGPIDGHDLPLLVKTFQFLKAQNKPVVLHAITQKGKGFQPAIDKQKKFHGLGPYDPETGDTAAAGQKTYSEIFAETLVKLANNDPKVVAITAAMPNGTALDLFRPSHPTRYFDVGIAEEHAVIFAAGMATKGYKPFCAIYSTFLQRAFDPIVHDVALQELPVVFCMDRGGLSGDDGPTHHGLFDISYLRCVPNIVHMVPKDEDELADMMQTALEHNGPSAIRYPRGTGPGSTVKAQPVALTIGKAEVIQDGADVVIFGLGALLPLAKETASRLSKLGLSVAVVNPRFVKPIDRACIEGYGRKCGLVITFEDHVLAGGFGSSVLEVLSAAEINTPVVRIGWPDQFIEHGKVDALRDKYGISVDGALHQAQPYLNAILQERLAHR
>NC_018014.1|WP_014786935.1|4147106_4147652_+|SRPBCC-family-protein
MRHNFQADQWLPFPVPIVFAFFANPQNLPPLMPYWQRAKIEELRLIAPPAPPPGSPVRLGTGVGTTMILSFRMLPGLPIRMNWHALIPEFEWNDHFCDSQTSGPFQYWRHCHTVREETRNGIAGTLVHDNVDYEFPGWLLGDLANWAAGRAQIRYIFRFRHRQTEKLMPLFAANLASRQPR
>NC_018014.1|WP_157178422.1|4144148_4146752_-|TonB-dependent-receptor
MSGLRAEAAISTDKDDHKPEPNANGGRVYDEVADQTRPSQTVHTFNIPPGTLAEVAAALEKETGLRMVISSKRYAGVQSPGVQGVLTIEEALTAALKDTSMAANFVSPERVSLDLLGADQSVSVVATSELISPKYTAPLRDLPQTLTIIPQAIIENTGSTTLVEALRTVPGITFGAGEGGNPVGDRPYIRGVDSQSSTFVDGMRDIGAQSREVFNLESVEVSKGPSGGFAGRGAAGGSLNLNTKMARRESFLAGTFSPGTANFFRGSADGGLKLTNSIAGRLNGVWQDSDTAGRDYVRNGRYGFAPALLFNLGHRVRLNTNYYHLMTNDVPDPGMPYNNPTFFARIDGRARTLQAGDGQPLVVNRNNFYGINSRDFRNEKVKTALGRVEVDLTEGVVLRNSYRFGKSNQDYVYSMVDDSQGNIYYGLVYRRAQQRFSAVDTSINQTDLSGHGKTGSIQHSFATGFEFSRERGWNSTYTLGGRNSAGVVAIPTYTVRNVATGAATAVSATRCPLGTGAAGGYYCTDLTNPTPDDPFYGVTSATNLTTAAPSAPVTNTLVKNFAPNKQVTGTRSVYGFDTIRFIKQLQATVGIRYDHYDSVYRSALTAVPVTTFPTISNLVNYQVGVGYKPVTAATIYGSVSSSATPPGNSLGQGQDPSAITSAVNQALPPEKTRSVEGGVKWELFGAKALATGAYFQSNTENVRITQADSTIAAVGTRRNRGLDFGITGYVSRKWQLFGGYTFMNAILLNSGGAGAAAGLMDGRRFPNTPEHSFSVTSYYSVTHKLNLGGGIYGAGKVFGADSPTAPKWVPGYARVDLYGSYRFNPHVELQANLQNVGDKTYFLQAYTTHYAQMAPGRQGRLTLNVHF
>NC_018014.1|WP_014786933.1|4143473_4144142_-|sel1-repeat-family-protein
MQVADHKTLELVRAAAERGVCQAQALYGQMHLDGKLVPQNPSLALHWFERAAVGGDVMAINMVGRCLDQGWGVAASPHLAAPWFRKAAERGLDWGMYNLATLLTMGSGVNEDKYEALHWFRKAADLGHAKSINIVGGFYEDGWVVAVDMAAAKDCYRRAAIAGDFRGQFNYARLLADAGEISSALSWLQKVPQTATPAFLLKMKRFLEQMPVAELRTFAVEL
>NC_018014.1|WP_014786943.1|4157362_4158334_-|UDP-glucose-4-epimerase-GalE
MNYLVTGGAGYIGGTVTRLLLQRGYTVTVYDNLCHSNRTALPDGATFVQGDLAQRDLLIDTLSKGKFDGVFHFAALIEAGESMNRPDLYFRNNTVGTLSLLECMQNTGANHLVFSSTAACYGEPKRTPIQEDDELLPTNPYGESKLLSESMMKWFGSQMGLRYAILRYFNVAGAVTGYGEAHEPESHLIPLILDAALGLRDSIRIYGQDYPTPDGTCVRDYIHVQDLADAHLLAMDSLNRQNRAIYNIGNGQGFSVRQVIESARRVTGRDIHVIEEARRPGDPAVLVASSDRIMRDLGWKPNFSDLDSIIASAWEWHQKLRAK
>NC_018014.1|WP_014786944.1|4158722_4159847_+|TonB-family-protein
MANEQAYLEDTQAAAVAERVAATPSQRELAFKTFGVMNAGEQSKSSVVTSLIINGLILLIVIAVSLTAKKIVKTATLTTLTAPIPIKKEAPPKPPPPKLPKPPVVKVTPPPQIPDVPKIEVPEPPKIQPVIMKASPVPVVTPPAPKAVTPPPAPKPVAIQLAQAASVPNNDPHPSAIRLGSQTNPINNTSGPAVSPVNLGRSGAPGMAAGNTGLGAPSKIAIGGSGSPNGQMGGRDNGPQPIKGISTGMTGGTGPTSARPVGAIAIAKATPPPSIQQPQASVTPAKTSPKVLFKPKPEYTEEARSLHLEGTVNVKIHVSATGTVSVVGVQSGLGHGLDQAAVRAVQGMRFQPAMANGQPTEWEGVVSINFQLAG
>NC_018014.1|WP_014786945.1|4159950_4161837_+|hypothetical-protein
MRNLRKSCIAGVAAILLAATAMPAMAGIPLLGKKKKEDLPARKLTPAQIALLDKAIAREADVIKVVQERAPLVETYIQNMKPDQALLQVPASDQHFLGRVDFKKVLSGDTYETEDNHKAKGKLGFFKNSMSYIGGLNKQLHLQFNEVGFIQMILVDAHSFDKETYKFGFVRNDFLGSVPTMVFDVEPATNKSRGRFFGRIWVERRNGNIVRFNGSFAGSEKDFREFYHFDSWRTNVQENLWLPTAFYVEESDPKSDEHTVKFKAVNHIWGYALKVPTGDAENVDVEVKGADDVSADAQDISPLGAQRAWVQQAEDNVVTRLFQAGLLDAPSDFDKIMEQIAGNVLAYNNIQVARPIRVRTLLTEPLESLAIGNTIVISKSLIDTTAVPGNNNEQVNNLYAIIAFQVAHIIQGHRLDTKYAFNDRLLFPDTSAFTRIPMHHTDHDNEEASKKTLELLSPKELNDASAQFGLYLAQLQDRYKSLTALNEPMIGDSLIKDPKTGVFWLQALVGKGGKLDMNDLKQNAAMPLSSFLRFDPWTDQVVQMHPAYEPLLSSRDKMPFEVTPVYLKLSYYKAPTNALDAAAAAAAAAGANATTDAAGNAVSAPPASTGTPAAAPVATPSTGVPANQ
>NC_018014.1|WP_014786946.1|4162032_4162620_+|hypothetical-protein
MLQTSQLTRFRRFLSGAALLAVMGGAAGLTGRLHAQASTTTASRAADLQIGLTYSGAPISDRSLFLYESNRLYGFGGYATLDFKAHYGIEVNIRQLNSGSGDKVYERTYEVGGRYIRHYGRFGPYGRASYGRGVFNFRNDAANLAYNLYAFGGGVDVNLVPSINLRGDFDYQKWMGFPLGLSPMVVTAGIAYHFH
>NC_018014.1|WP_014786947.1|4162704_4163307_-|porin-family-protein
MKKMMWMCALLAGAMSAHAQESRQDVSLSATGNIPPQVNGQGSQLNASMALGALASYRFMLTPRSALEANYSFSQYTSDLTATSFKRYQVHTRQQEVSFGYVYSRNYRNYNPFAEVGIGAIMFSPIRDFETQSLDAKRQISLGGFFGAGLAYEISPSYDIRIGYRGLLAKAPDFKLDNQNFKTGRYEVISMPTLGLAYHF
>NC_018014.1|WP_014786948.1|4163424_4164348_-|LysR-family-transcriptional-regulator
MDLFALETFLAVAEERSFSRAAARLHRTQPAVSQAVAKLEGQLGEALFDRASRDGLLTDAGEVLREYAQKLLNLRVEANHALGELRSLHRGTLNLAANEYTCLYLLPVLDGFRRLHPRVKVSVQRSLASRIADEVLLHSVEIGVLSFKPDDRALKSIVVYRDELAFVVNPRHALARTKSVSIRDLGDQNFIAHNVPSPQRIKVVEAFRRHKTELRIDVELPSLEAVRRFVELGNGVALVPGLTVERELKSGALVRVHVKELQMERKLRLVHRKEANLSHAALEFLKGVREYAETTGGAYCFVPERAD
>NC_018014.1|WP_014786949.1|4164460_4165624_+|2-isopropylmalate-synthase
MSTTSDRVFFFDTTLRDGEQSPGCTMHHEEKLRFAHQLGALGVDIIEAGFPIASDGDFASVQAIAREVRGPRIAALARCKTGDIERAARAVEGAGSNRIHTFIASSDLHLEAKLRITRQQALDQTGECVRLAKTYTEDVEFSAEDATRSDREFLVQMVEIAIAAGATTINLPDTVGYSTPAEYRAMFESMCARFSGAKDVIFSTHCHDDLGLAVINTVSGVEGGARQVEVSMHGIGERAGNAALEEVAALFKIRHDQYPFSNNLKMDEIGATSKMLDGIISFAPSPNKAIVGKNAFAHASGIHQHGMLANPLTYEIMKPAIFGVDANTIVLGKHSGRRALEHRLKELGFDLNKDEVEQTYTRFTALADRKKNIYDQDIVALVPQSVS
>NC_018014.1|WP_014786950.1|4165707_4166808_+|3-isopropylmalate-dehydrogenase
MKLKIALLAGDGIGPEVTQEAVNVLNAVAASGGHTFEYVPLLIGGAAIDAHGTPLPDETLQATLACDAALLGAVGDNKFNKLAPSERPEAGLLKIRSELGGFANLRPAVAYKALADNSPLRPEITEGADIMFVRELLGGLYFGQPRQWDKQTGRAHNTMVYTQEEVERVARIAFDIAAKRPKRKLTSVDKANVLECSQMWRFVVDQVAKDYPTVTVEHQLVDSMAIHLMNRPRDFDVVLTENLFGDILSDESGVITGSLGMLPSATLGGKVNLYEPVHGSAPDIAGQGKANPIGAILTAAMVLRFSANLEREAKIIEDAVVKVLEAGYRTSDIARGDIAGQTKVSTMEMGRLVLDRVEAELGVAAS
>NC_018014.1|WP_014786951.1|4166804_4167008_+|hypothetical-protein
MTQRTTSSPLLRVLIVNIFIIAGLVMVQRSGKLTGGMIGFYVFFFVAANALMYFSARARRRMMERNR
>NC_018014.1|WP_014786952.1|4167021_4168488_+|3-isopropylmalate-dehydratase-large-subunit
MSTPKTLFEKVWQQHLVAEPAGEPPLLYIDLQLVHEVTSPQAFEGLRLAGRKLRRPDRHIATVDHNVPTTSVQDRLHIVDQIASKQVQALRNNCAEFGIEFFDVQDASQGIVHMIGPELGATKPGMTIVCGDSHTSTHGAFGAMAFGIGTSEVEHVMATQTLPQPKPKTFRINVEGELPFGVTAKDIILDIIGRIGTDGATGYAVEYAGSAIRALSMEGRMTVCNMSIEAGARAGMIAPDETTFAYLKGRRFSPQGTAWDEAVAHWQTLPTDEGATFDREMHIDAATLAPAVTWGTSPGMHATIDGNVPTLDEAPSEADKKSFAKAYEYMDLKPGMPMDQIKIDTVFLGSCTNGRIEDLRAAAAVVKGHHIATKIRAMVVPGSQAVKRQAEAEGLDEIFKTAGFEWREPGCSMCLGMNPDILQPGERCASTSNRNFEGRQGRGGRTHLVSPEMAAAAAITGHFTDIRKWKSNELNIATKQMLAEGGSL

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Crispr_ID: NC_018014_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018014_11

4276908-4277007

Orphan

Consensus_repeat	Method
GGTCGCGCTGCGCGCGATTGAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018014_11

>merge|NC_018014|11|4276908-4277007|CRISPRCasFinder
GGTCGCGCTGCGCGCGATTGAGCGTTGCTTCCTGTGGCGCTCGGGACGTCAGGATTTGACGGCTCCAGATGCTCCCGGTCGCGCTTCGCGCGATTGAGCG

>NC_018014|11|10|4276908-4277007|CRISPRCasFinder
GGTCGCGCTGCGCGCGATTGAGCG	TTGCTTCCTGTGGCGCTCGGGACGTCAGGATTTGACGGCTCCAGATGCTCCC
GGTCGCGCTTCGCGCGATTGAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018014.1\|WP_014787053.1\|4279218_4280406_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240430
NC_018014.1\|WP_014787051.1\|4276339_4276510_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014787058.1\|4283588_4283930_-\|HigA-family-addiction-module-antidote-protein	unknown	unknown	gnl\|CDD\|274228
NC_018014.1\|WP_014787046.1\|4271902_4272880_-\|formamidopyrimidine-DNA-glycosylase	unknown	unknown	gnl\|CDD\|223344
NC_018014.1\|WP_014787054.1\|4280402_4281020_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_157178685.1\|4281016_4281622_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014787052.1\|4277078_4278989_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NC_018014.1\|WP_157178684.1\|4268948_4269317_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NC_018014.1\|WP_014787044.1\|4269470_4270511_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187593
NC_018014.1\|WP_014787047.1\|4272987_4274490_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NC_018014.1\|WP_014787060.1\|4284397_4285297_+\|Nif3-like-dinuclear-metal-center-hexameric-protein	unknown	unknown	gnl\|CDD\|376614
NC_018014.1\|WP_014787056.1\|4281657_4282446_-\|fimbrial-assembly-protein	unknown	unknown	unknown
NC_018014.1\|WP_014787061.1\|4285324_4286365_-\|DUF2157-domain-containing-protein	unknown	unknown	unknown
NC_018014.1\|WP_041592699.1\|4275469_4275880_-\|hypothetical-protein	unknown	unknown	unknown
NC_018014.1\|WP_014787057.1\|4282447_4283515_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227306
NC_018014.1\|WP_041593479.1\|4283939_4284218_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|226079
NC_018014.1\|WP_014787045.1\|4270631_4271843_-\|J-domain-containing-protein	unknown	unknown	gnl\|CDD\|223560
NC_018014.1\|WP_014787048.1\|4274546_4275221_-\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|238449
NC_018014.1\|WP_041592698.1\|4268538_4268934_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133394
NC_018014.1\|WP_014787050.1\|4275951_4276266_-\|L-rhamnose-mutarotase	unknown	unknown	gnl\|CDD\|377501

Protein	Function_ID	Function_description	E-value
NC_018014.1\|WP_014787053.1\|4279218_4280406_-\|hypothetical-protein	gnl\|CDD\|240430	PTZ00473, PTZ00473, Plasmodium Vir superfamily; Provisional.	4.3465e-07
NC_018014.1\|WP_014787045.1\|4270631_4271843_-\|J-domain-containing-protein	gnl\|CDD\|223560	COG0484, DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones].	9.79671e-135
NC_018014.1\|WP_014787058.1\|4283588_4283930_-\|HigA-family-addiction-module-antidote-protein	gnl\|CDD\|274228	TIGR02607, Virulence-associated_protein_I, addiction module antidote protein, HigA family. Members of this family form a distinct clade within the larger family HTH_3 of helix-turn-helix proteins, described by pfam01381. Members of this clade are strictly bacterial and nearly always shorter than 110 amino acids. This family includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is uncoded by the upstream member of the gene pair. [Regulatory functions, DNA interactions, Regulatory functions, Protein interactions, Mobile and extrachromosomal element functions, Other].	5.07628e-26
NC_018014.1\|WP_014787052.1\|4277078_4278989_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NC_018014.1\|WP_157178684.1\|4268948_4269317_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.85963e-12
NC_018014.1\|WP_014787044.1\|4269470_4270511_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187593	cd05332, 11beta-HSD1_like_SDR_c, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs. Human 11beta_HSD1 catalyzes the NADP(H)-dependent interconversion of cortisone and cortisol. This subgroup also includes human dehydrogenase/reductase SDR family member 7C (DHRS7C) and DHRS7B. These proteins have the GxxxGxG nucleotide binding motif and S-Y-K catalytic triad characteristic of the SDRs, but have an atypical C-terminal domain that contributes to homodimerization contacts. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.46352e-61
NC_018014.1\|WP_014787047.1\|4272987_4274490_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.07655e-89
NC_018014.1\|WP_014787060.1\|4284397_4285297_+\|Nif3-like-dinuclear-metal-center-hexameric-protein	gnl\|CDD\|376614	pfam01784, NIF3, NIF3 (NGG1p interacting factor 3). This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.	1.2773e-20
NC_018014.1\|WP_014787046.1\|4271902_4272880_-\|formamidopyrimidine-DNA-glycosylase	gnl\|CDD\|223344	COG0266, Nei, Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair].	3.85834e-47
NC_018014.1\|WP_014787057.1\|4282447_4283515_-\|hypothetical-protein	gnl\|CDD\|227306	COG4972, PilM, Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion].	1.09168e-05
NC_018014.1\|WP_041593479.1\|4283939_4284218_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|226079	COG3549, HigB, Plasmid maintenance system killer protein [General function prediction only].	2.72389e-27
NC_018014.1\|WP_014787048.1\|4274546_4275221_-\|carbonic-anhydrase	gnl\|CDD\|238449	cd00884, beta_CA_cladeB, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	2.18397e-87
NC_018014.1\|WP_041592698.1\|4268538_4268934_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|133394	cd04766, HTH_HspR, Helix-Turn-Helix DNA binding domain of the HspR transcription regulator. Helix-turn-helix (HTH) transcription regulator HspR, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	6.90036e-36
NC_018014.1\|WP_014787050.1\|4275951_4276266_-\|L-rhamnose-mutarotase	gnl\|CDD\|377501	pfam05336, rhaM, L-rhamnose mutarotase. This family contains L-rhamnose mutarotase which is a glycosyl hydrolase that converts the monosaccharide L-rhamnopyranose from the alpha to the beta stereoisomer. In Escherichia coli this enzyme is the product of the rhaM gene (also known as yiiL). The tertiary structure has been solved, in complex with L-rhamnose, and the catalytic mechanism determined. His22 is the proton donor. The enzyme naturally exists as a dimer.	2.44556e-38

>NC_018014.1|WP_014787051.1|4276339_4276510_-|hypothetical-protein
MNTVIWKCEQYIAGKLHEKTIFENEQQARDFARKLYDVRPDTILRIEPMPIQHVWN
>NC_018014.1|WP_014787050.1|4275951_4276266_-|L-rhamnose-mutarotase
MQRVCFTLKLRESTLPEYIERHRNVWPEMQDALRATGWTNYSLFLAPGGLLIGYVEVEDFNAAREAMKALPVNVRWQTEMLPFFDSSANADDAMQPLPEIFHLD
>NC_018014.1|WP_041592699.1|4275469_4275880_-|hypothetical-protein
MKRRIEWSALLLFVLGLCSMAAPHRMVHATVHHQQMPSSGSGGTRTSRTSRQNGRSARGGMTTEMDHHGSDLDRASQGVRPREVISSNVTTVAAIITPRFLLAPSTARGSLAPAADVVIANPYDALPSRGRAPPAL
>NC_018014.1|WP_014787048.1|4274546_4275221_-|carbonic-anhydrase
MQKLLEGYQKFQIEVFPKRAGLFKSLESGQKPSTLFLTCSDSRIVPDMILQSDPGELFISRNAGNIVPPYGEVNGGVTATIEYAVLALGVQNIVVCGHSDCGAMKAVLSGKQHPQMPTVDKWLQHSASAMQMVPPVGDNNITTPKDRLRTLTRANVLTQLQHLQTHPSVAYATSRGQLKLFGWVYEIHTGCIDTYDAASGRFLPLTADVLAPSVVHPRLELLAS
>NC_018014.1|WP_014787047.1|4272987_4274490_-|SulP-family-inorganic-anion-transporter
MALPQRYVRDLSASLVVFLVALPLCMGIALASGAPPAMGLVTGIIGGIVVGSIAGSPLQVSGPAAGLAVLVFEIIHEHGYAGLAPILMIAGVVQLIAGAAKLGRWFRAISPAVIHGMLAGIGLLIVFQQFHVMFDNKPKGSGLANLAAVPGTVMHGLFPLGPSSALEASLMGCFTITVMLLWERFRPEKLKLVPGALLGIAAASITAKLLHLPINHVQVPDSLLDSLSFPKLASFTEINGSAIGSALALALIASAETLLSAAAVANLQPAVKTNYDRELLAQGVGNILCGAVGAIPMTGVIVRSSANVQAGATSRLSAIMHGVWILGTIVLFASVLRAVPTSSLAGVLVLTGLKLVKVKDMRHLSSYGKVPILIYLATLITIVSRDLLTGVLVGVMLSVVALLYNVTRLTIHSEAMPGDNQWQLRFVGSATFVRIPLISAALEKVPANATVRIITDDLSYIDHSCLEMLRDWVDLANRNGSRVVLEQHALENKYWTSKTA
>NC_018014.1|WP_014787046.1|4271902_4272880_-|formamidopyrimidine-DNA-glycosylase
MPEGNEVHRWAERHTAAFAGRKLNILPGPNHRFSDAHLVDGKKLLKVHAVGKHLGYEFPGELYLHVHLGRFGDFTEGCGPLPEPKGLLRAVMQRAGSGRPSRSQKGQPHNLTCAHDDGTQPFPPEDVDWWELRGPTDCSVYDAAKWQALLDRLGPDPLAHEPDGHDDPKRAFDKILAKKTSIGELLMDQSIIAGIGNIYRAELLFRHRVNPFTPGNEMPLNRLKAIWKDAIPLLKAGMIDRRIVCTDRKDRPSKKALAERGEEHYVYRRHGKPCFVCGETILRKDVAGRTLYWCPKDQQTTAAENESALKPGISLKSSRVKPKRL
>NC_018014.1|WP_014787045.1|4270631_4271843_-|J-domain-containing-protein
MAPTPSKDYYGALGIKKTATTDEIRKAFRKLARKYHPDVNPNDKKSEEKFKEISEANDVLSDDKKRKIYDQLGFYSDNIDPAQAEAAARGGYGGGGFGGGSPADAGGVPFDFGGFDFSGGAPQQGGGGFGSSFRDIFGGMFSGGGPAGRQQAQRGPRAGTDLEYQVEVDFWTAIRGGTTRIEISRQDPCSTCKGAGVVGPPQNCPQCNGTGQVTQMNGRMKFNVQCPRCGGSGRIQQGCPTCHGEGTVTRRDSLEFRIKPGTRDGQRIRLAGKGNAGSMGSPAGDLYLIMKAGQHPVFTRIADDIRVTVPVMAFEAALGTKIDVPTIDGRAQLKIPPGTQTGQKLRLREKGVPSAAKEGLRGDQIVEVQIVVPKIQDERSKEILRELAKLNPEDPREAMFSKV
>NC_018014.1|WP_014787044.1|4269470_4270511_+|SDR-family-NAD(P)-dependent-oxidoreductase
MIAKVLKLGTKAAWWATKRTARGYRTETNIALGIIGVAVAANEAYKAKQRATAMCGKIVVVMGGSRGLGLEIARQFGLGGAHLVLVARNEDELRSALGKLHAEGAIPNGAAAHIVVGDVSRQEDCEHAIASATKRFGRVDVLVNCAAIMQVAPFEDMTTEAFESAMKVNFFGALYATQAVLPQMLSRGSGSIVNIASVGGKIAVPHMLPYVASKFALVGFSEGLHAELRHKGIRVTTVCPGLMRTGAESGVKFAGNAEKEYAWFKFGAEAPLVSINARAAARKIFAATVAGKAEITITPQAWLGARAVGLAPNFSQQFAAAVNHLGLPAANGNRETTTGAEIEARQ
>NC_018014.1|WP_157178684.1|4268948_4269317_-|GNAT-family-N-acetyltransferase
MSPRSIEAAAAGLPRTLFGVVVRHKGRVVGMARVIGDGGLCFQISDVAVHPDHQARGLGKALMGRIVAYLQETVPAGSFVNLLADGEAHRLYAQFGFRPTAPDSIGMDLVIGSAAFAVEPVR
>NC_018014.1|WP_041592698.1|4268538_4268934_-|helix-turn-helix-transcriptional-regulator
MATKRRSKGAYMISAVAEMYAIHPQTLRLYEREGLLRPSRSDGNTRLYTDEDLERLEFILNLARDLGVNIAGIAIILQMRERMEQMNSDMQNFVSYMRDEMLSRMQQPPRSESGLVPLKRTVVVGKTVRKR
>NC_018014.1|WP_014787052.1|4277078_4278989_-|molecular-chaperone-DnaK
MGKIIGIDLGTTNSCVSVMEGGEPKVIANEEGGRTTPSIVAFTKSGERLVGQVAKRQAITNPENTIYSIKRFMGRRPNEVNEEMKMVPYKVVTKGDNIYIDAQGKEYTPPEISAMILQKLKKAAEDYLGQSVTEAVITVPAYFNDSQRQATKDAGKIAGLDVKRIVNEPTAAALAYGLDKKKDETIVVYDFGGGTFDVSVLEVGEGVIEVKSTNGDTHLGGDNLDQRLVEFLIDEFRKQEGLDLKGKGNEMALQRLRDAAERAKIELSTTMETEINLPFITADATGPKHLVVKLTRAKFESLVEDLLQKSIGPCKQAMKDAGIDASKVDEVVLVGGQTRMPRMQALVKELFGKEPHKGVNPDEVVAIGAAVQGGVLGGEVKDLLLLDVTPLTLAIETMGSVATAMIPRNTTIPTKKTETFSTAADSQTEVEVHVIQGERPLASQNRTLGKFKLSGIPPAPRGVPQIEVTFDIDANGILNVTAKDNATGKDQKITITSSSGLSKEEVERMAKEAEAHAGEDKEKREEIEARNQLDSMVYNVDKMFKENGDKITGDERQQVEEALNDAKSTLTGSPSATELKAANERLTAASHKLAEAMYKQGQAPTDGAAAAAGTADEAPKHDEGVIDAEYVDVDHK
>NC_018014.1|WP_014787053.1|4279218_4280406_-|hypothetical-protein
MSHPRQETRPSLQPSRPGEEGYLLLGLAVVCFLLLLALSVAAPRVAKELERDRELESEHRALEYVRAIQLYYKKNNSYPTSVEQLLGSSTAGASVSIGPGASLKFLRQRYKDPLTGDDFRLIHTGEAKTQVKGFFGEPLEGMPVSNLGAAQGMVSSINATPAGTFGGSSAVGAPSSASGAASGNSAFGGAGSSTSSFGSSAFNNSGTGTSTGTGTGATGSTGTSSTGTGSSMSGTSATNFQGSKGAFLGVGSNAKGPGLVEWNGSANIEEWEFLYDPRVELLKAKVSIFGGGPPTVGSGSMGSGFGPATGANGTGNTTNGTGTSSGGFGSGSSSGFGSGSSSGFGSGSSSGFGSGSSSGFGSSGSSGFGSGSSTTPTNGTGTSGSGTTTPTPTNP
>NC_018014.1|WP_014787054.1|4280402_4281020_-|hypothetical-protein
MSALKAGTEDRKKLIAAGAFGVLALGYLAYTFLGSSSSSDTPASTSPVITTSAPVSTNTVSPAATATARIVPSKLDPTLHPEGMLLSESLVYGGHGRNIFAAPGTQTEAAAPKIPAAAASPRYVPPTPVNTGPPPPPPIDLRFFGTATRRDGKPQAFLLRGEDVFVAGPGDIVSRRYRVDEVSGNSVLVTDLTNNNQQRLPMSPQ
>NC_018014.1|WP_157178685.1|4281016_4281622_-|hypothetical-protein
MSNEARRESMRKALSLINLHFAAAGLLLLICLYFGVRLFLVSGNTGTQGDEAIVIAQSRVAAAEVAAKPLRGVDTKLGESESEANRFYESRLPYAYSDVASSIGGIAKASNVRWSRASYVQTVPTNGVTELRIDGSVSGEYRNVAEFINAVERSKSFFLIQTLALSGAQGGLVNLQLRIGTYLREPMPSFAAAQATAGSKP
>NC_018014.1|WP_014787056.1|4281657_4282446_-|fimbrial-assembly-protein
MRVSINLATRPYVELDRLLRQLRIAIGVLAVVAIALGIWLHSMTAQARAQQAQLDRLNAQAQTLQRERAANEARLRQPVNAATLGRNQFLNTLFARKAFSWTAVLMDLEDVMPNGVQVTSIEPIIASTGEVTIRLRVLGERDRTVDLVRNLEHSKRFISPRLAGEAQQTANRTGATTIGANGLPQLVAATGANGLPAISGVEFEIVSGYNPLQPRMREKIAPHTTPERDEPTGTPVRRRPRKVVDNSPPPQPSLARRRAGAR
>NC_018014.1|WP_014787057.1|4282447_4283515_-|hypothetical-protein
MPSLLPKSTIQVRPRIAVEIRPEGVYAASATDAAGLLAQIASAPLPAGAVVPSLRVGNIVDRIAVIAALKKVLPAVQVGKGRDVTLIVSDTAVRVLLLDFDEIPSKAEEALPVLRFRLAKLLPFNPELAQVSYQVMSRHAMVLQVLVVAIPNEVLAEYESAVREAGFEPGAVIPSTLAVAAAIDEAGTAAALVVNGSEFAVTTAILRRGELLLHRTLELKSKTMAEVAALVAHEPANVAIDAEMARASFVQSGEDSEVAVAEMVQAGILHDAEDPDRAELELLQSISVAAAYFEDSLAVAPEEVLTAGTLSPEALGPMLAETGLHAREVLQSTDLMTTTSIPRGLLAGLRGALKS
>NC_018014.1|WP_014787058.1|4283588_4283930_-|HigA-family-addiction-module-antidote-protein
MLMHNPPHPGTVLREYLRDADVTSFAGKIGVARTTLSRLLHGHTGVSAPMALRLSAALGTSAMLWMNLQVQFDLWQAIQAEKAARKKARAAAPSRVATKKAKPKRSPTYAKAA
>NC_018014.1|WP_041593479.1|4283939_4284218_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MIGSFRHAGLEKFFKSGSKAGIQPAHASRLELQLGVLNAAEGPEDMAVPGWKLHALQGKLRGHYAVSVNGNWRMVFAFDGTDAILVDYSDYH
>NC_018014.1|WP_014787060.1|4284397_4285297_+|Nif3-like-dinuclear-metal-center-hexameric-protein
MTDLSRREFMATGAAFAAGVTLTPSALAAPPSLTAGDVIDRIKQEVGVPWREKTVDNLLTGTRATPVRGIATTMMATLDVVERCVADGKNMIVTHETPFYLHQDGTDDIKDDAVLRYKLDYCAKHEVAIFHFHDHWHARQPDGIAQGMVNQLGWAKHVVDAANPKKLSFDGVPLAQFTRTMQKTLQARTMRVLGDPKLPVRRVVTSWGFCGREGGIKLFSAPETDVLICGETREWELVEYCQDSIRSGNKKALIVVGHVLSEQGGMVLCRDWLKPFFPGTPVAFIPAMEPFWNPQEPVS
>NC_018014.1|WP_014787061.1|4285324_4286365_-|DUF2157-domain-containing-protein
MRTYTEAEVVHAAGRAGISKEGLDRLRAELSGGQAGRSGFEAAHVAYYLGALLICGAMGWFVTDAWDHLAGITLFAVAMVYAAVFGGTGYALSRRPSTWVPGGVLTTVAVCMTPLAVYGIERQIGWWPSGDPGAYSHFHPYINASWLLMEACTILAAGIALRIVRFPFLTAPAAYAFWYMSMDAPRLFGLSLTFHMQAWITVGFGVVLLGIAWFADGERELDLAFWFYLFGLLAFTGGLSALGSGKQSGLLLFGLLHLLMLPCALVLQRRVFLVFGAIGTFIFLATEATRFFRNSLGFSVALTLIGVVMIAAGIFYKRHEARLSAALFKLTPQRVLHHHAHGVGPA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_018014_10	10.1\|4157176\|19\|NC_018014\|CRISPRCasFinder	4157176-4157194	19	NC_018014.1	4737090-4737108	2	0.895

1. spacer 10.1|4157176|19|NC_018014|CRISPRCasFinder matches to position: 4737090-4737108, mismatch: 2, identity: 0.895

gagttttcggtatgactgc	CRISPR spacer
gagttttcggtctgagtgc	Protospacer
*********** *** ***

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_018014_8	8.5\|3773359\|29\|NC_018014\|CRISPRCasFinder	3773359-3773387	29	NZ_HG938354	Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence	97625-97653	8	0.724
NC_018014_8	8.5\|3773359\|29\|NC_018014\|CRISPRCasFinder	3773359-3773387	29	NZ_HG938356	Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence	94269-94297	8	0.724

1. spacer 8.5|3773359|29|NC_018014|CRISPRCasFinder matches to NZ_HG938354 (Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence) position: , mismatch: 8, identity: 0.724

attcgcctcggaagggcgcctcagactca	CRISPR spacer
cggcgcctcggaagggcgcatcaggtact	Protospacer
   **************** ****.. *

2. spacer 8.5|3773359|29|NC_018014|CRISPRCasFinder matches to NZ_HG938356 (Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence) position: , mismatch: 8, identity: 0.724

attcgcctcggaagggcgcctcagactca	CRISPR spacer
cggcgcctcggaagggcgcatcaggtact	Protospacer
   **************** ****.. *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1900161 : 1907911

Yellowstone_lake_phycodnavirus(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_157178595.1\|1900161_1901256_-	CDP-glucose 4,6-dehydratase	A0A0P0YMS6	Yellowstone_lake_phycodnavirus	1.7e-14	25.0
WP_014785499.1\|1901249_1902020_-	glucose-1-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_014785500.1\|1902127_1903468_+	lipopolysaccharide biosynthesis protein RfbH	A0A0P0YLZ6	Yellowstone_lake_phycodnavirus	5.7e-41	33.8
WP_014785501.1\|1903540_1904338_+	aldolase	E5ERI3	Ostreococcus_lucimarinus_virus	1.3e-16	30.7
WP_014785502.1\|1904350_1905058_+	SDR family oxidoreductase	E5ERI5	Ostreococcus_lucimarinus_virus	1.2e-21	31.1
WP_014785503.1\|1905041_1906118_+	3-dehydroquinate synthase	A0A0P0C619	Ostreococcus_mediterraneus_virus	3.2e-26	35.6
WP_014785504.1\|1906114_1907911_+	thiamine pyrophosphate-binding protein	E5EQ70	Micromonas_sp._RCC1109_virus	1.9e-76	32.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_018014

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection