CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015571	Porphyromonas gingivalis TDC60, complete genome	11 crisprs	cas2,cas1,cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7,cas4,cas3,cas7b,cas8b4,cas5,cas6,DEDDh,cas13b,Csx28,PD-DExK	11	8	1	1

1. NC_015571

CRISPR-Cas detection and classification

Crispr_ID: NC_015571_1

• CRISPR_ID: NC_015571_1
• CRISPR_location: 6623-6770
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015571_1

Consensus_repeat	Method
GAACCAAGGACCCTCTGATTAACAGTCAGATGCTCTAACCAACTGAGCTAAG	CRISPRCasFinder

spacers of NC_015571_1

>1.1|6675|44|NC_015571|CRISPRCasFinder
GAAGAATAGAAAAACGGCTTATGAGAGCGCTTTCTCTTGGGCTC

CRISPR arrays and Neighbor proteins around NC_015571_1

CRISPR arrays

The CRISPR arrays of NC_015571_1

>merge|NC_015571|1|6623-6770|CRISPRCasFinder
GAACCAAGGACCCTCTGATTAACAGTCAGATGCTCTAACCAACTGAGCTAAGGAAGAATAGAAAAACGGCTTATGAGAGCGCTTTCTCTTGGGCTCGAACCAAGGACCCTCTGATTAACAGTCAGATGCTCTAACCGACTGAGCTAAG

>NC_015571|1|1|6623-6770|CRISPRCasFinder
GAACCAAGGACCCTCTGATTAACAGTCAGATGCTCTAACCAACTGAGCTAAG	GAAGAATAGAAAAACGGCTTATGAGAGCGCTTTCTCTTGGGCTC
GAACCAAGGACCCTCTGATTAACAGTCAGATGCTCTAACCGACTGAGCTAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_043889965.1|2008_3028_-|acyltransferase-family-protein	unknown	unknown	gnl|CDD|225813
NC_015571.1|WP_013815110.1|14217_14988_+|2-phosphosulfolactate-phosphatase	unknown	unknown	gnl|CDD|377205
NC_015571.1|WP_013815105.1|5095_6475_-|MATE-family-efflux-transporter	unknown	unknown	gnl|CDD|240548
NC_015571.1|WP_013815102.1|0_1422_+|chromosomal-replication-initiator-protein-DnaA	unknown	unknown	gnl|CDD|273037
NC_015571.1|WP_013815104.1|3107_3815_+|NAD-dependent-deacylase	unknown	unknown	gnl|CDD|234777
NC_015571.1|WP_013815108.1|7401_9981_+|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl|CDD|223616
NC_015571.1|WP_004583405.1|1434_2007_+|N-acetyltransferase	unknown	unknown	gnl|CDD|100048
NC_015571.1|WP_013815114.1|20564_21260_+|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224759
NC_015571.1|WP_004583413.1|13179_14208_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|273466
NC_015571.1|WP_043889966.1|18233_20480_+|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815115.1|21254_22256_-|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl|CDD|239200
NC_015571.1|WP_005874752.1|3888_5043_-|metallophosphoesterase	unknown	unknown	gnl|CDD|277331
NC_015571.1|WP_013815109.1|10120_13132_+|serine-hydrolase	unknown	unknown	gnl|CDD|224389
NC_015571.1|WP_148271453.1|6959_7262_+|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_013815112.1|16892_18230_+|GHKL-domain-containing-protein	unknown	unknown	gnl|CDD|227333
NC_015571.1|WP_013815111.1|15532_16882_+|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225114

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_043889965.1|2008_3028_-|acyltransferase-family-protein	gnl|CDD|225813	COG3274, COG3274, Predicted O-acyltransferase [General function prediction only].	1.91054e-19
NC_015571.1|WP_013815110.1|14217_14988_+|2-phosphosulfolactate-phosphatase	gnl|CDD|377205	pfam04029, 2-ph_phosp, 2-phosphosulpholactate phosphatase. Thought to catalyze 2-phosphosulpholactate = sulpholactate + phosphate. Probable magnesium cofactor. Involved in the second step of coenzyme M biosynthesis. Inhibited by vanadate in Methanococcus jannaschii. Also known as the ComB family.	6.72157e-81
NC_015571.1|WP_013815105.1|5095_6475_-|MATE-family-efflux-transporter	gnl|CDD|240548	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.	2.49528e-131
NC_015571.1|WP_013815102.1|0_1422_+|chromosomal-replication-initiator-protein-DnaA	gnl|CDD|273037	TIGR00362, DnaA, chromosomal replication initiator protein DnaA. DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_015571.1|WP_013815104.1|3107_3815_+|NAD-dependent-deacylase	gnl|CDD|234777	PRK00481, PRK00481, NAD-dependent deacetylase; Provisional.	6.40551e-107
NC_015571.1|WP_013815108.1|7401_9981_+|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl|CDD|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NC_015571.1|WP_004583405.1|1434_2007_+|N-acetyltransferase	gnl|CDD|100048	cd03358, LbH_WxcM_N_like, WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization and transacetylation reactions of keto-hexoses. It contains an N-terminal LbH domain responsible for the transacetylation function and a C-terminal isomerase domain. The LbH domain contains imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), typical of enzymes with acyltransferase activity.	2.87631e-63
NC_015571.1|WP_013815114.1|20564_21260_+|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.09974e-11
NC_015571.1|WP_004583413.1|13179_14208_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|273466	TIGR01140, L_thr_O3P_dcar, L-threonine-O-3-phosphate decarboxylase. This family contains pyridoxal phosphate-binding class II aminotransferases (see pfamAM:pfam00222) closely related to, yet distinct from, histidinol-phosphate aminotransferase (HisC). It is found in cobalamin biosynthesis operons in Salmonella typhimurium and Bacillus halodurans (each of which also has HisC) and has been shown to have L-threonine-O-3-phosphate decarboxylase activity in Salmonella. Although the gene symbol cobD was assigned in Salmonella, cobD in other contexts refers to a different cobalamin biosynthesis enzyme, modeled by pfam03186 and called cbiB in Salmonella. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	2.20574e-68
NC_015571.1|WP_013815115.1|21254_22256_-|tRNA-dihydrouridine-synthase-DusB	gnl|CDD|239200	cd02801, DUS_like_FMN, Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. 1VHN, a putative flavin oxidoreductase, has high sequence similarity to DUS. The enzymatic mechanism of 1VHN is not known at the present.	1.24319e-109
NC_015571.1|WP_005874752.1|3888_5043_-|metallophosphoesterase	gnl|CDD|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.48097e-50
NC_015571.1|WP_013815109.1|10120_13132_+|serine-hydrolase	gnl|CDD|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	5.14836e-77
NC_015571.1|WP_148271453.1|6959_7262_+|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	1.26604e-05
NC_015571.1|WP_013815112.1|16892_18230_+|GHKL-domain-containing-protein	gnl|CDD|227333	COG5000, NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms].	3.06869e-32
NC_015571.1|WP_013815111.1|15532_16882_+|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl|CDD|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.78173e-166

Protein sequences

>NC_015571.1|WP_013815105.1|5095_6475_-|MATE-family-efflux-transporter
MSSQQIQALESEKIPKLLFHYALPAVVGTAVNSLYNIVDRIFIGNGVSEYALSGLAITFPILIFLMAFGMLVGAGASVRVSILLGRKDIKEAEHTLANAIFLTFFTQALTIIPCYIFMEPLLRLFGASERTLPYAMEYLQYVVPANIFSALSFGFNAIMRASGYPRKAMITMIIGAMTNVVLDYIFIYPLGMGISGAAIATVISMIVCSVYVLSHFFRKDSIVRFHRSAFRLSLPVISGITAIGVAPFAMHLTGSLVNIIMNRSFVSYGETADATDLAIGAFGIINGYAMLFFMIIIGVAQGMQPIVGFNYGAKNPGRVKSAYRYSCGVNLLVSFLGFALAMLMPRTIVSLFTNSEQMIELSASALRTALIGLSLVGFQVTTTQFFQSIGFSHKAIFLSLTRQIIFLIPCLLIIPRFMGLDGVWWSLPISDLASVVLSFVLITIQMKHFNQSKKTTFAE
>NC_015571.1|WP_005874752.1|3888_5043_-|metallophosphoesterase
MKVFLEAFLLQYLLTLYIAYRGGQALPQKSLWRKGFHLLMGVVFTLYLIGFAGNRVLPDAVMSCIMSVTGFWFVMSIYAMFAMVIVEIARVVDKRFLHRFDRLSERVQARIRLGLFVLIGLSSALLVIHGLNIVRYPVVKHMDIRLDRPAIDGRQSMKVALLTDIHISETVTAGHIREMVERTLAERPDIVLIGGDMIDYHGRYARRDSITEYMRRLQDETPMGAYYVLGNHEYRADEVEKREWFRSIGHLVIDQVVTPGNAFYLIGRDDSTNVFRAPLHKLMPHVDTTKASILLDHQPHKLDSVAMTGVDLALYGHTHNGQIWPFTILTQLAFEKSWGYLRKGHTQFYVSSGVGAAGPAIRVFTESEIVILNVRFASENKPVH
>NC_015571.1|WP_013815104.1|3107_3815_+|NAD-dependent-deacylase
MNKKRLVVLSGAGMSAESGISTFRDANGLWENYPVEDVASIDGFRRNPALVLKFYNARRRDYAGCKPNAGHIGLAEMEKEYDVRIITQNVDDLHERAGSTRVIHLHGELMKNRSVATDSVLYPVDPTNPDLHVGDLAPDGCQLRPFIVWFGEAVPMIEPAIEEVTQADILVVIGTSLNVYPAAGLLNYAPRNCPIYLIDPKPVRSTSRQDIRYIHAPATEGVRMLRQELRDIIDC
>NC_015571.1|WP_043889965.1|2008_3028_-|acyltransferase-family-protein
MTTKGRNTTVDVLRVLAGLMVIGIHTSGEYVLEGVAEGANFIAGLCWETVVQPAVPIFVIISGAFVLGRNETWGDFYRKRIPRLLVLLAFWLPFYWLWLWLKGDDIGSYLAGFWQGRSFVHLWYVVMLLGLYAVVPLLNEIIRRCEADGEKAARKRLWTLSTILLLLGILSNTYDYILGYNRFFPFLWPDYLGYFLVGYTLKCHAPQRSLPALSLYGLSTISLFFASRYAFEHGEGLYFYRNLSPLIVLSAISLFALFVSWGGCGGKLARIGKMQGDILGIYLVHIAVLNVVTKILVLTTPSLMQCAWLNIPIRVGLVFFVSWGVVRLMKRLPICRYLV
>NC_015571.1|WP_004583405.1|1434_2007_+|N-acetyltransferase
MIHPTAIVEDGCVLGQGTRVWHFSHLMCGAEVGENCNIGQNVVIMPEVRLGRGCKVQNNVSLYSGVVCEDYVFLGPSCVFTNVINPRAFIERKSEYRPTHLHEGVSIGANATILCGITIGAYAMVGAGTVVIRDVPPYALVVGNPARRIGWVSRAGHRLSFDDKGMAVCPETGERYREVEETGTIEPVSD
>NC_015571.1|WP_013815102.1|0_1422_+|chromosomal-replication-initiator-protein-DnaA
MNYHSTNVNEIWDACLRILQDIVDERAYRTWFLPIIPVSIEGDTLTLQVPSQFFCEFLEGNFVEQLRTVLGRVIGPNASLQYNALVDNSSPKYPGTVTLAGCADGGQAAEQFDVNLLHRHMLNAATHSEAQDFDTQLNSRLNFRNFYQSECNYVARSVAEAIAASPGNTPMNPFFIYGASGVGKTHLCHALGLRVREMHPRLKVLYVSSHLFEMQFTTAARMGTINDFIVFYQQVDVLIIDDIQWLIGKKKTQLAFFQVFNHLYMLGKQIVLTSDKPPVDLNGMEERLVTRMAGATCVKIERPDLKLRREILQQRTLQSGVRLDESVLNFIAENVCDNVRELEGTLVSLITNSVVVGKEIDLTFAKRIVRQAVRLEKKEVTIECIQQAVSRVFQVQIEQMKSKSRKQDIVQARQVVMFLSKKHTAQSLSAIGELMGGRNHATVLHGCRCVTNEMEMNASFRSSVERAEQLIAN
>NC_015571.1|WP_148271453.1|6959_7262_+|DUF1661-domain-containing-protein
MLRKTWRENFFVLVPQVFISRAKTKNFTRVFFRIYEPQSRYFRFENQVSNKPQTSIAPLCNSKSVTAGSSGSKKLFSCYRSRTESLCRAIGTSPSWPVRD
>NC_015571.1|WP_013815108.1|7401_9981_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MAYDFTQTFRNSLEYSYQEATRLGVVAVTQDMLVLGIIRDGDNGAIDIMRHYGINLYELKRLIELEAIAESLPASPEGSPIFTPSAREAINDATDICADMEDEAVSPVHLLLSILNSTQESLVQKIFMKQGIKYDTILSDYFGQRNPSEGKSPSEMEILDGYQDNDFDDEEDESSPPSGNGGAGRGSGDAPEQNTGGGDTTTTTRSGGDTPALDTFGTDITAMAAAGKLDPVVGREQEIERVIQILSRRKKNNPVLIGEPGVGKSAIVEGLAERIVNRKVSRILFDKRIISLDLAQMVAGTKYRGQFEERLKAVLDELKKNPQIIFFIDEIHTIVGAGSAAGSMDTANMLKPALARGQIQCIGATTLDEYRKNIEKDGALERRFQKVPIAPSTAEETLTILQNIKEKYEDYHGVRYTDEAIKAAVELTDRYVSDRFFPDKAIDAMDEAGASVHITNVVAPKEIEILEAELTSVRENKLSAVKAQNYELAASFRDQERRTQQQIAEEKKKWEDQMSKHRETVDENVVAHVVALMTGVPAERLSTGEGERLRTMADDLKTKVVGQDTAIEKMVRAIQRNRLGLRNEKKPIGSFLFLGPTGVGKTYLAKKLAEYLFEDENAMIRVDMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTERVRRKPYSVVLLDEIEKAHADVFNLLLQVMDEGQLTDSLGRRVNFKNTVIIITSNVGTRQLKDFGQGIGFHSEKDEEANKEHSRSVIQKALNKTFSPEFLNRLDDIILFDQLGKTEIRRMVDIELKSVLARIHRAGYDLVLTDEAKDVIATKGYDLQYGARPLKRTLQNEVEDRLTDLILSGQIEKGQTLTLSARDGEIIVQEQA
>NC_015571.1|WP_013815109.1|10120_13132_+|serine-hydrolase
MKRFLFSAITILSLSVLYTATAPARTNMGAMHAQQSKDYPFLLFGGVDSKDVKRWVDDRMKAMSTEEKVGQLLMPIVYPSLQEEKVKQAEQLVRTCHIGGILFQKGTLSEQYTMTRRLQEAAGTPLLIALDGEWGLHMRLKDAPRFPRNMGLGHQKDNQLLYNYGREVARQCRLMGIHINFAPVLDVNNNPKNPVIGTRSFGDNPRRVAERGIAYAQGLEDGGVMAVAKHFPGHGNTTEDSHKTLPTVFASREELENTELFPFKEFFRAGLSGVMTAHLNVPALEAKKNTPSSLSHAICTDLLRQEMGFKGLIFTDGLAMQGVQTAGSQPISVRAILAGNDILLGPVDPVKTFSEVLAAVEDRTISKELLDEKCRKILAFKYALIICKGVSKEVPAEEVVRQVNSREAERMSEDLWRASITILKNKKQFLPLSEENRIACVNLDGAASNTFTQELGLTSKDCYSYAKGSNSTRTQELLSKLKGYDAVIVTVRHTQPDWAGTFLHRLTEQNHTAIVFFTSPYVADRIPVAMDKARAIVVAYENVKEAARMAAYKIRDRVVVSSGGGIPVVQEEEDTDPTANMMPPTELSSGLIPMPAVDRIAKEALRQGAFPGCRILAVHRDKVVYDKSFGTLDGSARGGKVSSSTIYDLASVTKVVATTPAVMLLVQDGKLKLSDRLGTLLPRFARTDLKDITVQQLLLHEAGLRPSINFYESLIDSSSLDGKLLSPRRSSGWVRVDTNMWGNPFFGFRSDLVSGQFRPDYPFRFSSNLYLSKEVKEIVLNTIASTPRNGVGRYKYSDLGFILLQQIVEKVSGKSLNVFVEERIFRPIGAGSLGYLPLDKYSVSRIAPAQNDKFLRKSIVRGTVDDEAAACLGGISGNAGVFGTAEDVARVLDMFIHEGTYKGHRIIDQKIFRQFITTHGKGNRRCLGFDKGRASMAESASGSTYGHTGFTGTCVWVDPESELIFVFLSNRTYPNRLNKTLMTASIRPRLHQAIYEALGIAEQ
>NC_015571.1|WP_004583413.1|13179_14208_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MIFGHGDEGITPLSSEIVNFSTTVWTDGDKDHLEKHLVENLNCIRHYPEPDAGTLRQMLAKRNSVDNNAILVTNGPTAAFYQIAQAFRGSRSLIAIPSFAEYEDACRMYEHEVCFYPSNEDIGEADFSNMDFCWLCNPNNPDGRLLQRTEILRLLNDHPDTTFVLDQSYVSFTTEEVIRPADIKGRKNLVMVYSFSHAYGIPGLRIGYIVANKDFMKRVAAFSTPWAVNALAIEAAKFILIHPAQFTLPIRKWQRNTVDFITALNRLDGVEVHPSGTTFFLLRLKKGTAAELKKYMLEEYNMLIRDASNFRGLDESYVRITTQRPAQNQLFIKALETFLEKY
>NC_015571.1|WP_013815110.1|14217_14988_+|2-phosphosulfolactate-phosphatase
MLQISLCPSPVLYPYYKTEQEEYTVVIVDIFRAGTTITTALMNGAVGIIPIATVEEAEIYAGNGFLVGGERGTKRLPFAHFGNAPEEYTRQAVEGKQLVLSTTNGTRAVDIAAGALHVIIGAFINLEAVARYCIAKQKPVMVLASGWQNRMSTEDCLFAGALAATIVRLGEEVICEDGASVFQELWGNYNTHEKLTAYLNGRDHYERLRANKLERSVPYCTSLNLTEIVPEMTFKISAASTDCPANRLFLPVTPPF
>NC_015571.1|WP_013815111.1|15532_16882_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MKKSGNIIVVDDNKHVLTALKLLLTGSFETVTLLPSPKTLLSTIVEVHPDVLLLDMNFSTGINTGNEGLYWLDQVRSRFPDLPVVLFTAYADIRLAVEALKRGASDFVVKPWNNAELLESLRMAMNKAASTQVTATPKEDDSVFLGKSKAMCEVLELADRIGDTAAHVLITGENGTGKGVLAEYIHARSPRSRQPMLTVDMGALSETLFESELFGHVKGAFTDAKSDRAGKFETASGGTIFMDEIGNLSLALQAKLLAVLQQKVVTRVGSNTPIPVDVRIISATNSDLPLSVAEGRFREDLLYRLNTIHIEMPPLRRRREDIVPMAVFFLHRYARQYGKEVPELTPEAEALLSDYPWPGNVRELQHCIEKAVILSRSSSLSAADLSLPKSVDAHPTATGVASTPQTLDEMEKTAIKQALARNGSNLSNVARELGISRQTLYNKMKRYGL
>NC_015571.1|WP_013815112.1|16892_18230_+|GHKL-domain-containing-protein
MGRRKTGSFGLHLLFTIVMAVVGTWSAAAGHYAITVFAAGLVIFSALRLRLLYRRHLQDLSLLLNAIENGDYSVRFSEMGGNVSHRTFNRTLNRIKEILSRSRDEAIAGEQFLVHVLEQIPVGIMMVAPEGYVYSTNTVLLRLLGLPVITHLDQLRRVSPDMPRLFRSAATDSGIHIKLTTEREEQEVSLRFSSFRIREKIYHIYTLSNIGKELDARETESWIRLIRVMTHEIMNSIAPITSICDTLLDNLQSSADEEMLSTGLDTIRSTGVGLLSFVQDYRKFTAVPPPEKEDIALYAFLSGILRLQEELLSSNDIKVDIEEIPVELTVPADRRQLTSVLTNLVKNAAEAEYPADTEKRLLRIRAEERLDSLDEHRLLFHVENNGTPIPQEVFDNMFVPFYTTKTGGSGIGLSLSRYIIRLHGGNLLARRTADGFTSFVIELPL
>NC_015571.1|WP_043889966.1|18233_20480_+|hypothetical-protein
MRKPIVRFLLSFFWLLGVCASHMVGQSLPSVSKEIRELSNRTEQQTSLFDRKESEAFALETVRMISDRTPFLFRLAEGRSWEADVRGRSWASRVLPIVHRLKHGGIPWEQYLSSDSLCMEARLYGKYDSVTGAYKRGVVSFRSDIPQRNKVDDLTALALLGENVYAEEFDFGNRQIFPNPIRREAEAFYTYRLDSLYEKDGITYRRIAFRGLSGLNRGTVTIDATHGQLAILEMRVMMKGVITESYRVELGEVEPGLFLPIGLSVVIDRNRLWASLHNGYSASISYTGEQLDKTVLFVYMPTDSSRYRLPDELPVASVWAVRSSFGREDSSTYWKNVVVGRDHTLHQHVPWHRALAWGHKYRIGERWRLGNEGLVWALFYYNYADHLWLGQSLTAIYDMAPGIRWEIKPGLYYVTKRRKAVWTLDSKLYYSPPQRGLLQLSAGHRSFDLYSTRERIDQLTDLMMELLNGQGPTTRYDDKFVRLTNSIDLLPKLNVETSVMLAERNPLPHGETWSLFGGSITDILNISNADPDLPRIVPHHRLLEVRAKMTFNPRPYYRYTADGFLIREGEGIRAPLLSLSYRGAFGMGRKSDARFHHLDLSIQQRLVFSPAASLFYQLNVGGYFDRSVIYPSEYFFLKGGNAFWRFGDSMEAAFQTLPPYTATADKHLILQTSYRASRLLVNFLPFVFLKTNDEALHFKARWNMVSRKPYLEMGYSESIGTLMQVGVFYGGYNFFYERGVAIRFTFNM
>NC_015571.1|WP_013815114.1|20564_21260_+|winged-helix-turn-helix-transcriptional-regulator
MKYKKLLFDLIDYLDAFESLHDGGSHEPEIKDFADFLSWRCGKKKKQEEEVVSVTRERAAGAKNIARGVSLLHRYSRFYIKKALTKSPLQTEDEYTYLVSLMNGESMTKTELNNLNAMEKTSGAEVMRRLLKANLIEQRPDEEDRRSMRVSITPEGRKVLVNLFPNLRLCAETLVSALSDEQLTAFDHLLWLLCECHNEMFTGKHDAELTDLHAETCGLKQSAGGALSKRL
>NC_015571.1|WP_013815115.1|21254_22256_-|tRNA-dihydrouridine-synthase-DusB
MKIGAIDLGVEPLLLAPMEDVTDVAFRIMCKQFGADLVYSEFLSADALIRQVAGTFRKMAIDESERPMAVQIYGRDVASMVEAARLCESAGPDLIDLNFGCPVKRVAGKGAGSGMLRNIPLMIEITREVVKAVKLPVTVKTRLGWDNDSKIIVDLAEQLQDCGIAALTIHGRTRAQMYTGTADWTLIGEVKNNPRMQIPIIGNGDVTTPQEARRAFDVYGVDAVMVGRASIGQPWIFEDMKHFLRTGETLPSRPFSYYMDILRRQTLNNIRKLDERRGILHTRRHIAASPIFKGIPNFKPMRVAMLRATTQEELFALMDEVEKMIGSADSAAL

Crispr_ID: NC_015571_2

• CRISPR_ID: NC_015571_2
• CRISPR_location: 237463-237560
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015571_2

Consensus_repeat	Method
CTTCGAATCCGTTTATATAAGGCCTAAAAT	CRISPRCasFinder

spacers of NC_015571_2

>2.1|237493|38|NC_015571|CRISPRCasFinder
ATTACTACGGGAAAGCCCAGCGAACGCATTGCCGGAAT

CRISPR arrays and Neighbor proteins around NC_015571_2

CRISPR arrays

The CRISPR arrays of NC_015571_2

>merge|NC_015571|2|237463-237560|CRISPRCasFinder
CTTCGAATCCGTTTATATAAGGCCTAAAATATTACTACGGGAAAGCCCAGCGAACGCATTGCCGGAATCTTCGAATCCGTTTATATAAGGCCTAAAAT

>NC_015571|2|2|237463-237560|CRISPRCasFinder
CTTCGAATCCGTTTATATAAGGCCTAAAAT	ATTACTACGGGAAAGCCCAGCGAACGCATTGCCGGAAT
CTTCGAATCCGTTTATATAAGGCCTAAAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_013815245.1|232386_234087_+|glutamine--tRNA-ligase/YqeY-domain-fusion-protein	unknown	unknown	gnl|CDD|235424
NC_015571.1|WP_010956453.1|234114_234762_+|DedA-family-protein	unknown	unknown	gnl|CDD|223659
NC_015571.1|WP_004583612.1|230844_232005_+|AI-2E-family-transporter	unknown	unknown	gnl|CDD|223701
NC_015571.1|WP_013815251.1|243739_244315_+|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl|CDD|376519
NC_015571.1|WP_157761733.1|230514_230607_-|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_004583622.1|239402_239552_-|DUF4295-domain-containing-protein	unknown	unknown	gnl|CDD|379486
NC_015571.1|WP_004583632.1|245714_247511_+|chloride-channel-protein	unknown	unknown	gnl|CDD|238233
NC_015571.1|WP_013815253.1|247471_248536_-|mechanosensitive-ion-channel	unknown	unknown	gnl|CDD|182386
NC_015571.1|WP_004583623.1|239570_239759_-|50S-ribosomal-protein-L33	unknown	unknown	gnl|CDD|177033
NC_015571.1|WP_013815248.1|237569_238865_-|acetyl-CoA-hydrolase/transferase-family-protein	unknown	unknown	gnl|CDD|223504
NC_015571.1|WP_004583624.1|239778_240018_-|50S-ribosomal-protein-L28	unknown	unknown	gnl|CDD|234736
NC_015571.1|WP_004583610.1|229378_230383_-|malate-dehydrogenase	unknown	unknown	gnl|CDD|223117
NC_015571.1|WP_013815247.1|235761_236781_+|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223528
NC_015571.1|WP_004583625.1|240240_242508_-|inorganic-phosphate-transporter	unknown	unknown	gnl|CDD|376541
NC_015571.1|WP_005874816.1|237105_237279_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815252.1|244311_245718_+|sugar-transferase	unknown	unknown	gnl|CDD|274398
NC_015571.1|WP_013815249.1|242704_243328_-|DNA-binding-protein	unknown	unknown	gnl|CDD|273496
NC_015571.1|WP_102947768.1|230575_230698_+|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_013815246.1|234822_235758_+|YitT-family-protein	unknown	unknown	gnl|CDD|224203
NC_015571.1|WP_013815242.1|227684_229106_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|378820

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_013815245.1|232386_234087_+|glutamine--tRNA-ligase/YqeY-domain-fusion-protein	gnl|CDD|235424	PRK05347, PRK05347, glutaminyl-tRNA synthetase; Provisional.	0
NC_015571.1|WP_010956453.1|234114_234762_+|DedA-family-protein	gnl|CDD|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	2.05569e-31
NC_015571.1|WP_004583612.1|230844_232005_+|AI-2E-family-transporter	gnl|CDD|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	6.19746e-42
NC_015571.1|WP_013815251.1|243739_244315_+|threonylcarbamoyl-AMP-synthase	gnl|CDD|376519	pfam01300, Sua5_yciO_yrdC, Telomere recombination. This domain has been shown to bind preferentially to dsRNA. The domain is found in SUA5 as well as HypF and YrdC. It has also been shown to be required for telomere recombniation in yeast.	4.65026e-52
NC_015571.1|WP_157761733.1|230514_230607_-|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.00360915
NC_015571.1|WP_004583622.1|239402_239552_-|DUF4295-domain-containing-protein	gnl|CDD|379486	pfam14128, DUF4295, Domain of unknown function (DUF4295). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are two completely conserved residues (K and Y) that may be functionally important.	4.93541e-19
NC_015571.1|WP_004583632.1|245714_247511_+|chloride-channel-protein	gnl|CDD|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	9.43748e-102
NC_015571.1|WP_013815253.1|247471_248536_-|mechanosensitive-ion-channel	gnl|CDD|182386	PRK10334, PRK10334, small-conductance mechanosensitive channel MscS.	1.49128e-59
NC_015571.1|WP_004583623.1|239570_239759_-|50S-ribosomal-protein-L33	gnl|CDD|177033	CHL00104, rpl33, ribosomal protein L33.	1.21956e-18
NC_015571.1|WP_013815248.1|237569_238865_-|acetyl-CoA-hydrolase/transferase-family-protein	gnl|CDD|223504	COG0427, ACH1, Acetyl-CoA hydrolase [Energy production and conversion].	1.62269e-113
NC_015571.1|WP_004583624.1|239778_240018_-|50S-ribosomal-protein-L28	gnl|CDD|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	6.96682e-31
NC_015571.1|WP_004583610.1|229378_230383_-|malate-dehydrogenase	gnl|CDD|223117	COG0039, Mdh, Malate/lactate dehydrogenases [Energy production and conversion].	2.08354e-62
NC_015571.1|WP_013815247.1|235761_236781_+|NAD(P)-dependent-oxidoreductase	gnl|CDD|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	2.0029e-43
NC_015571.1|WP_004583625.1|240240_242508_-|inorganic-phosphate-transporter	gnl|CDD|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	3.15944e-08
NC_015571.1|WP_013815242.1|227684_229106_+|alpha/beta-hydrolase	gnl|CDD|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	3.18902e-12
NC_015571.1|WP_013815252.1|244311_245718_+|sugar-transferase	gnl|CDD|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	1.55214e-129
NC_015571.1|WP_013815249.1|242704_243328_-|DNA-binding-protein	gnl|CDD|273496	TIGR01201, HU_rel, DNA-binding protein, histone-like, putative. This model describes a set of proteins related to but longer than DNA-binding protein HU. Its distinctive domain architecture compared to HU and related histone-like DNA-binding proteins justifies the designation as superfamily. Members include, so far, one from Bacteroides fragilis, a gut bacterium, and ten from Porphyromonas gingivalis, an oral anaerobe. [DNA metabolism, Chromosome-associated proteins].	7.03433e-42
NC_015571.1|WP_102947768.1|230575_230698_+|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	4.74182e-05
NC_015571.1|WP_013815246.1|234822_235758_+|YitT-family-protein	gnl|CDD|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	5.11744e-47

Protein sequences

>NC_015571.1|WP_005874816.1|237105_237279_-|hypothetical-protein
MKYIDKQHIACFSWIESALFYSRSEHTPKGGRATPYSDSGYAVERTELRSTALRATL
>NC_015571.1|WP_013815247.1|235761_236781_+|NAD(P)-dependent-oxidoreductase
MGNKRVLITGATGFIGGYLVDEALRRQYEVWAAVRPHSDRSRLTDSRIRFVEIDYRDPSDIARLADKIAPEGESAWHLVIHNAGITKARDTSLFREINAEQTKRFLIGLQGAKHCPERFVLMSSMGSYGAPPDDCQPLSSSSVPKPTTAYGESKLLAEQYVQTFVTIPYTIIQPTGVYGPHDQDYLMAIRSVDKGFDFSTGNTPQTLTFIYAEDLASAVFIAAEHPDAAGQKYIVSDGKEYTDIEFGRMIQHLLGRKNVCHLRIPLPLVKATCYIGQKWADISGTLTPLNLDKYAIIAQRNWRCDSSPIRAIGFSPRYNLEQGLAETIRWARTTGQIRR
>NC_015571.1|WP_013815246.1|234822_235758_+|YitT-family-protein
MALTKTSKLYYKVHDYILIILGCSIYAFAWTGLILSQGITTGGLAGISTLIKIATGIPAAIPYNIINLGLAVLALIFLGWRFMVKTVISVVIMAIIIPIGEEYLVVTEIVNGVKVFTPLLLPNEPALALVIGSILSGLGIAIVFSVNSSTGGTDIIVAIMNKYKNMSFGRAILLVDCTIILCSYLVNVYIAGKSPSDAFNLLIYSAIEVILVSTVLDWYLNSNRQSVQFLIFSLKNEELSNAIQERIKRGCTLLDATGGYSGQPCKVLVVVARKTQSLSIHRIIQEIDPKAFVSESVVRGVYGEGFQAIRK
>NC_015571.1|WP_010956453.1|234114_234762_+|DedA-family-protein
MGFIQWCLAHLNYWTIMFLMAIESSFIPFPSEIIVPPAAWMAATGQNGLNVFLVILFATIGAGIGAAVNYILSLLLGRPIVYAFANSKLGHLCLINEEKVRYAERYFDKNGAVSTLVGRLIPAVRQLISIPAGLARMKFLPFISYTMLGAGIWNCILAAIGYNLAKVPGIETQEQLLEKVNKYSHEIGFSIMGVVVVVLLIMFYKKKRRSARKGN
>NC_015571.1|WP_013815245.1|232386_234087_+|glutamine--tRNA-ligase/YqeY-domain-fusion-protein
MNENKNSGIEEKKSLNFIEQIVESDLSEGKNDGRIQTRFPPEPNGYLHIGHAKAICIDFGIAQRYGGVCNLRFDDTNPVKEDVEYVDAIREDIEWLGFHWGNIYYASDYFQELYDFAERLIREGHAYVDEQTAEQIAAQKGSPTVPGTASPFRDRPAEESLDLFRRMNAGEFEEGAMTLRAKIDMASSNMHFRDPIIYRIIKHPHHRTGNEWNVYPMYDFAHGQSDYFEGVTHSICTLEFEVHRPLYNYFIELLRKDSYAPRQIEFNRLNLTYTMMSKRKLLQLVKDGLVSGWDDPRMPTLCGYRRRGYTPESIRNFIDKIGYTKYDGIIDVALLEHAVREDLNKRATRVSGVIDPIKLVITNYPEDKTEEMAAVNNPEDESAGVHTITFARELYIEKEDFMEDAPKKYFRMTPGQEVRLKSSYIVRCTGCKKDEDGSVVEVYAEYDPLTLSGMPESNRKVKGTIHWVSARHSLPAEVRLYDRLFTDENPSDIKDKTLAEMLNPDSLKVLKSCRVEPFLADAAPGSHFQFQRIGYFTVDPDSRPGALVFNRTVSLKDSWQKAQKNA
>NC_015571.1|WP_004583612.1|230844_232005_+|AI-2E-family-transporter
MQSFFDREFTFDRTARLFFIILLVGGIMAIVIGLRGILIPFCLSWILAYVLMPLVRFVQYRLHFRFRFLSVITVLVFISALIFFAILSLVPAVEEEVSKTITLLQQYRIDENLLQMLPAPIRKFLSESGSMNDLFKGISYEKLMENSKEIFGQLNKLVSGTISLFSYTTIFFIGVLYFIFILFDFEKLGKGFVNLFPVGHRIRVRSILKEVDKNMNSYFRGQALIALCVGILLSIGYKIIDFPLGVTLGLFIGMLNLIPYLQIVGLIPIVFLSVLKAAQTGQNFFVVLALGIGVMMIVQVIQDTILTPNIMGKRMGMSPAMILLSISIWGSLLGFFGLFIALPLTMSLYSVYKRYVIQDPKFIREENEETMPRKGLFRKHSRKEEK
>NC_015571.1|WP_102947768.1|230575_230698_+|DUF1661-domain-containing-protein
MVREAKNSRATTKIFSRLFFRILRPQSEHFPFVFSRKQIS
>NC_015571.1|WP_157761733.1|230514_230607_-|DUF1661-domain-containing-protein
MAREFFASRTKTKIFSSHVLRTVEWLIFGA
>NC_015571.1|WP_004583610.1|229378_230383_-|malate-dehydrogenase
MSYLTEEKLTIVGAAGMIGSNMAQTAAMMRLTPNLCLYDPFAVGLEGVAEEIRHCGFEGLNLTFTSDIKEALTDAKYIVSSGGAPRKEGMTREDLLKGNAEIAAQLGKDIKSYCPDCKHVIIIFNPADITGLVTLIYSGLKPSQVTTLAGLDSTRLQSELAKHFGIKQSLVTNTRTYGGHGEQMAVFASTAKVNGTPLTDLIGTDKLTNEQWAELKQRVVKGGANIIKLRGRSSFQSPSYVSIEMIRAAMGGEAFRWPAGCYVNVPGFEHIMMAMETTITKDGVKHSDINQLGNEAERAALKESYSHLAKLRDEVIAMGIIPAIADWKTVNPNL
>NC_015571.1|WP_013815242.1|227684_229106_+|alpha/beta-hydrolase
MKHKIIIIIYVVVLLMTTMSCKSQKFAGDWSGRIPRGNGSLALVVHLKQTGNTWQGSMDSPDQQAFGIPLSSVTVVGDSLSIAVQDLLLSYKGKLKNDSIEGEFRQGRFGTMMSLYRGLDAAKPYRPQTPVPPFPYDVTDVKILHKTGGFTIAGTLTAPKDANKTKGTVILISGSGLQDRDETIFGHKPFAVLADQLTRHGYAVLRCDDRGFGESAGDASQATTDTLAGDIESELAYLRQHYPRLTDKVFLIGHSEGGIIAPMVARRVGGIAGLVLVGAPSVKGAEILLSQNAAMDEFATGQPQSQAKRAALEELIRQATAPGDSSDIRTRIESYCRSNASVLFPQAMTDEMKEQGIKLMTEQLSNPWMRHFLTYDPAPLLDVTSGEGSHPLPPTMAIYGGRDKQVLHEVNMSKMKSLLGIETGNTANKVVYLPEVNHIMQPAEFGTPDEYAFLNRTVDTELMEIVCSFLDSL
>NC_015571.1|WP_013815248.1|237569_238865_-|acetyl-CoA-hydrolase/transferase-family-protein
MQWQELYRQRVCSADEAVVDSLKPGTKVVFGHAAAAPVRFSQAMYRQRERLENITVFHMLYFGDAPHLAPEMRSHVHPTLNFLEGNSRPASRDRRVDFIPCHFHEVPELFRQGFFPLDVAVVQVSTPNEEGYCSFGVSCDYTKAAAECAPVVVAEVNKQMPFIGGENLIHISKLTHIIEVDEPIAEVLPPAISDLELRIGQNCASLIKDGDTLQLGIGGIPDAVLRALEGHKDLGIHTEMFTDGVMRMIRKGIINGKKKTLHPEKVVTSLIFGSKELYDFVNNNPVIECYPVDYINNPDVIGKNDRMVSINSCLEMDLMGQAASESIGYEQFSGSGGQVDFLRGAKRSKGGISIMAFPSTAKKGAESRIVPILKEGACVTTGRNEVDYVVTEYGVARLRGATLRQRAEALTAIAHPDFRPALEEEIRRRFE
>NC_015571.1|WP_004583622.1|239402_239552_-|DUF4295-domain-containing-protein
MAKKSVATFKKGDGRTYSKVIKMVKSPKTGAYTFQEEMVPNEAVKDFFK
>NC_015571.1|WP_004583623.1|239570_239759_-|50S-ribosomal-protein-L33
MAKKVKGNRVQVILECTEHKESGMPGISRYITTKNRKNTTQRLELKKYNPILRRMTLHKEIK
>NC_015571.1|WP_004583624.1|239778_240018_-|50S-ribosomal-protein-L28
MSKICQITGKKAMVGNNVSHSKRRTKRVFDVNLFRKKFYWVEQDCWVVLRISAAGLRLINKIGLDAAIKRAAEKGFLNA
>NC_015571.1|WP_004583625.1|240240_242508_-|inorganic-phosphate-transporter
MSLIFTAIVVFLFILAIFDLIVGVSNDAVNFLNSAIGAKAAPFKIIVGVAALGVFCGAAMNNGMMEIARHGIFRPEHYTFSELMVVFLSVVITDVVLMDMFNSLGMPTSTTVSLIFELLGGSFFMAMTKVGGTVGFQDLLNTEKALSVILGIFLSVGIAFFFGMVVQYLSRLLFTFNYRRNLRWLAGLFGGVAVTSIIYFMLIKGLKGVSFMTEESTAWIAANTGRLVLYCLVVSIILMQVLYWLRVNVFKVIVLLGTFALAMAFAGNDLVNFIGVPLAGYSSYLDFNANGNGQYGTYLMGALNEPASTPVYFLVAAGIVMVYALITSKKAHNVIKTSVDLARQEEGEEMFGSSGLARSIVRFSTTTANAVSRIIPRPVGRWIDSRFNQDELIMAKGAAFDLVRASVNLVLAGLLIAFGTSLRLPLSTTYVAFMVAMGTSLADRAWSRESAVFRITGVFSVIGGWFITAGAAFILCFLVTMVNHFGGYPAMAGMIILAIFLLVRSHIRFDKKKKSETKDTVFIDMMASHDKEEIWQLLAKHIRQKQLALLDFAENNYMQMTDGFINEDLKRLRRSINDQNAERQMLKVNRRKETLGIRRIEEAKSVVKNTWFHLGCNSCEQIVFCLKRIAEPCKEHVDNNFNPLPKVCVSEFLAAREKLILYIKEAKLIVSNETDEILDPMTYRGKDIKKELKQLRKTQLSRIQQGASSLKISLVYLNLLQESQQLVNILDDLIHATEKLFDPVARIGTDEEFFN
>NC_015571.1|WP_013815249.1|242704_243328_-|DNA-binding-protein
MAKFVMREMPDMQGTGKRTMYPKMISRGTMGLDEIADLISSQSTFSPGEVKGLVTALARTIAHGVASGYTVKIEEIGSFSASLTLHKGVEPEEAEGGTRRNAASVTIGGVNFRPDKALILEARTRVHLVRTTVRRPRRPNLTREERLALALRHLDGHSLLKVADYCRLTGLGRTAAAEELRAFDREGLIDSTGSGTHKVYIRNKAGI
>NC_015571.1|WP_013815251.1|243739_244315_+|threonylcarbamoyl-AMP-synthase
MLNDIQRSEAKKAAEVMRKGGIILYPTDTIWGIGCDATNEEAVRRIYRLKERADSKSMLVLIDSEAKLQGLMDEVPELAWDLIELTTKPLTIIYPQAKGVAPALIASDGSLGIRLTRETFSAELCRLMRVPIVSTSANISGQPSARTFGEIAPAILDGVDYIVECRREEPAGQASSIIRLGTRGEVEVIRQ
>NC_015571.1|WP_013815252.1|244311_245718_+|sugar-transferase
MTRMQLHRLRYLLADVFGIVASYLSYNTLRYLTEEQERIYSTLSEYLFNAKSLWVGILYLLFWLSLFALSGYYNKPIAKSRISELLTTVASVLVGSVVVFLLLVVDDIVHDTALYLRLFFMMVATVLPWVYFPRLWVTTFGIKERKKTKGYHRVLLIGSGTIAEETASWLKSVNDMATTRLHFVPPTTREGFEQSLKSFATLVAEAVQESKPHQIILAVDCPDASFISLLLYQLYPFHMPVCVPMRSMLFAGAKVNVQGMKGEPMVDMTATNMSECAKSIKWFADRLFSLLMLILLIPVYAVIAVLVKRSSRGPVFFGQERIGLHGRPFTIYKFRTMYLDAEKDGPSLSFDGDSRVTPIGRILRKYRMDELPQFWNVLRGDMSFVGPRPERAFYIRQLVERAPYYYLLHNVRPGITSWGMVRYGYASTLDEMLERLQYDFLYYENMSLRLDIEVLLYTCQTIFKGLGK
>NC_015571.1|WP_004583632.1|245714_247511_+|chloride-channel-protein
MKDKETSRYGWFLHFLLWRERHINERLFLIILSLIIGILSAFAAVLLKNTIHIIQHFAFDRIRETSYLYLIFPVVGILITWLFVRYVVRDDIGHGVTKILFAISQRKSRIKPHNMWSSLAASSITIGFGGSVGAESPIVLTGAAIGSNLGRLFRMEQKTLMLLVGCGAAGAISGIFKAPITGLVFVIEVLLLDLTMSSVLPLLISSVSAAAVSYIITGQGAMFSFTLNDPFSMDRIPYALLLGVFCGLVSFYFSKVMFVFESKLKNFPHYRQRYLISAFILCGLIFLFPPLYGEGYDTINALLGGQYSSLMDGSLFEPYSNSYWVLFVFLGFIIITKVFASVATNSGGGCGGLFAPSLFMGALSGFIFAYALNFFPFIEVYLPQKNFALLGMAGVMAAVMHAPLTGIFLIAELTGGYNLFLPLMLVSTSSYATIRLFMPHSIYSLRLAQKGKLLTHQKDKAVLTLMTLDAVIEKDFEPVRPDMTLGDVVHVFGISHRNVFPVLDENNLLMGLVLLDNIRNIMFRPELYERFKVSRFMVSPPAKIVNTMSMETIMRIFDDTKAWNLPVIDEQGCYLGFVSKSKIFNSYREVLVETFSGD
>NC_015571.1|WP_013815253.1|247471_248536_-|mechanosensitive-ion-channel
MPADSVSAGLSASINDIKVTNRMGLKIFFPLQNLSVDTTKVNKIAEVVSPEALKQIKEIKPSQWTELLTQWGGKALSFGIKVLIALVAFYLGKLLLNALVKWLDRIMVRRSFEPAARTFLRSFANIGGFVLLIVIIISTLGFQPVSLAALLASVGVAVGMGLSGQLQNLAGGLIVLLTKPFKVGDYIVSNNVEGVVDGVTLFHTTVMTFENKYIFIPNGLLSSNVIINYSRMAVRRNEWIIGIEYNEDFDRVKTLLLRLIDEEPRIIKDPLPTVVLKELADSSVRVMARAWCATDDLWNVYWDINERIYSEFNRQGIAFPFPQLTIHGSAAGQERRGKSTEAQSPENVSTNTSL

Crispr_ID: NC_015571_3

• CRISPR_ID: NC_015571_3
• CRISPR_location: 251189-251297
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: cas2,cas1,cmr6gr7

Consensus repeat of NC_015571_3

Consensus_repeat	Method
AGGAAGCCGTTGTCACGTGACAATCAC	CRISPRCasFinder

spacers of NC_015571_3

>3.1|251216|55|NC_015571|CRISPRCasFinder
TCCGTGCATGATGCAGGAAGCCGTTGTCACGTGACAATCACTCCGTGCACGATGC

CRISPR arrays and Neighbor proteins around NC_015571_3

CRISPR arrays

The CRISPR arrays of NC_015571_3

>merge|NC_015571|3|251189-251297|CRISPRCasFinder
AGGAAGCCGTTGTCACGTGACAATCACTCCGTGCATGATGCAGGAAGCCGTTGTCACGTGACAATCACTCCGTGCACGATGCAGGAAGCCGTCGTCACGTGACAATCAC

>NC_015571|3|3|251189-251297|CRISPRCasFinder
AGGAAGCCGTTGTCACGTGACAATCAC	TCCGTGCATGATGCAGGAAGCCGTTGTCACGTGACAATCACTCCGTGCACGATGC
AGGAAGCCGTCGTCACGTGACAATCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_013815261.1|254621_255674_+|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815267.1|260663_263759_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187766
NC_015571.1|WP_013815256.1|249966_250869_-|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|275036
NC_015571.1|WP_143733548.1|259241_259349_+|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_013815251.1|243739_244315_+|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl|CDD|376519
NC_015571.1|WP_004583623.1|239570_239759_-|50S-ribosomal-protein-L33	unknown	unknown	gnl|CDD|177033
NC_015571.1|WP_021662107.1|252670_253339_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_005874926.1|260353_260644_-|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl|CDD|187856
NC_015571.1|WP_013815262.1|256034_258038_-|hypothetical-protein	unknown	unknown	gnl|CDD|378965
NC_015571.1|WP_004583624.1|239778_240018_-|50S-ribosomal-protein-L28	unknown	unknown	gnl|CDD|234736
NC_015571.1|WP_013815253.1|247471_248536_-|mechanosensitive-ion-channel	unknown	unknown	gnl|CDD|182386
NC_015571.1|WP_013815249.1|242704_243328_-|DNA-binding-protein	unknown	unknown	gnl|CDD|273496
NC_015571.1|WP_004583632.1|245714_247511_+|chloride-channel-protein	unknown	unknown	gnl|CDD|238233
NC_015571.1|WP_004583625.1|240240_242508_-|inorganic-phosphate-transporter	unknown	unknown	gnl|CDD|376541
NC_015571.1|WP_013815252.1|244311_245718_+|sugar-transferase	unknown	unknown	gnl|CDD|274398
NC_015571.1|WP_013815268.1|263820_264594_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	gnl|CDD|187792
NC_015571.1|WP_013815254.1|248572_249460_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NC_015571.1|WP_012458603.1|251474_252527_+|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815263.1|258067_258658_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_021662106.1|253317_254409_-|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_015571.1|WP_013815267.1|260663_263759_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	3.4e-64	211.5	0.3
NC_015571.1|WP_005874926.1|260353_260644_-|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	8.1e-20	65.7	0.2
NC_015571.1|WP_013815268.1|263820_264594_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	3.2e-59	194.9	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_013815267.1|260663_263759_-|CRISPR-associated-endonuclease-Cas1	gnl|CDD|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.81881e-68
NC_015571.1|WP_013815256.1|249966_250869_-|T9SS-type-A-sorting-domain-containing-protein	gnl|CDD|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	3.30199e-10
NC_015571.1|WP_143733548.1|259241_259349_+|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.000634986
NC_015571.1|WP_013815251.1|243739_244315_+|threonylcarbamoyl-AMP-synthase	gnl|CDD|376519	pfam01300, Sua5_yciO_yrdC, Telomere recombination. This domain has been shown to bind preferentially to dsRNA. The domain is found in SUA5 as well as HypF and YrdC. It has also been shown to be required for telomere recombniation in yeast.	4.65026e-52
NC_015571.1|WP_004583623.1|239570_239759_-|50S-ribosomal-protein-L33	gnl|CDD|177033	CHL00104, rpl33, ribosomal protein L33.	1.21956e-18
NC_015571.1|WP_005874926.1|260353_260644_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	8.2336e-16
NC_015571.1|WP_013815262.1|256034_258038_-|hypothetical-protein	gnl|CDD|378965	pfam12836, HHH_3, Helix-hairpin-helix motif. The HhH domain is a short DNA-binding domain.	0.000696007
NC_015571.1|WP_004583624.1|239778_240018_-|50S-ribosomal-protein-L28	gnl|CDD|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	6.96682e-31
NC_015571.1|WP_013815253.1|247471_248536_-|mechanosensitive-ion-channel	gnl|CDD|182386	PRK10334, PRK10334, small-conductance mechanosensitive channel MscS.	1.49128e-59
NC_015571.1|WP_013815249.1|242704_243328_-|DNA-binding-protein	gnl|CDD|273496	TIGR01201, HU_rel, DNA-binding protein, histone-like, putative. This model describes a set of proteins related to but longer than DNA-binding protein HU. Its distinctive domain architecture compared to HU and related histone-like DNA-binding proteins justifies the designation as superfamily. Members include, so far, one from Bacteroides fragilis, a gut bacterium, and ten from Porphyromonas gingivalis, an oral anaerobe. [DNA metabolism, Chromosome-associated proteins].	7.03433e-42
NC_015571.1|WP_004583632.1|245714_247511_+|chloride-channel-protein	gnl|CDD|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	9.43748e-102
NC_015571.1|WP_013815252.1|244311_245718_+|sugar-transferase	gnl|CDD|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	1.55214e-129
NC_015571.1|WP_013815254.1|248572_249460_+|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.69614e-15
NC_015571.1|WP_004583625.1|240240_242508_-|inorganic-phosphate-transporter	gnl|CDD|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	3.15944e-08
NC_015571.1|WP_013815268.1|263820_264594_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl|CDD|187792	cd09661, Cmr6_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.45991e-60

Protein sequences

>NC_015571.1|WP_013815256.1|249966_250869_-|T9SS-type-A-sorting-domain-containing-protein
MAFAQVPKGNDKSKDEHILTWALPEELVIDNNSIVATYNSFLTPFNGMTMACASFFDVQDLLPYVGYTINRIDFHPTADEKNYEQVAASKFYICIWGNKEQTEVLYEQALPTIHKEDLSFGYGVDGEEDYYDEPMYLAELETPFVIPAGKALYIGCRVETQEGHAVGFGLDDGPAMKGKGDLVGSYLPGAAPMPFVPLSDIPARSMDANFFIYSRISLGSGTQDILQHRMKVYPNPATTELHVEALSAWVGEQAAVYDMRGRRVSARMVDSEKLCIDIASLPAGVYVLRIGSYSAKFEKR
>NC_015571.1|WP_013815254.1|248572_249460_+|tetratricopeptide-repeat-protein
MTDRFLHILRLSALCLLFSALLPPLFGQPTTTRQDSLPADYTRLIDRSFEALGQGNLELAEQALRQAIKAYPDLPSGYALMNNLGAIQQRQGKPEEALLTYSAALQKLPDDKLLRTNRAMLLTEMGRTDEAIFDYNELLRAEPDNEIFHYGRAMLYLAKGMYGDAESDLEEILRVNDSSLKARLGIALVATMKGEYDKAERLYNYVIDKLPKNAAAYEGRARLFLNKGMKGYALRDINKAFEYATPPAASLFVLRGEINAAIGDKKAAAEDYAVAESRGYSKESLDLLRAALRKQ
>NC_015571.1|WP_013815253.1|247471_248536_-|mechanosensitive-ion-channel
MPADSVSAGLSASINDIKVTNRMGLKIFFPLQNLSVDTTKVNKIAEVVSPEALKQIKEIKPSQWTELLTQWGGKALSFGIKVLIALVAFYLGKLLLNALVKWLDRIMVRRSFEPAARTFLRSFANIGGFVLLIVIIISTLGFQPVSLAALLASVGVAVGMGLSGQLQNLAGGLIVLLTKPFKVGDYIVSNNVEGVVDGVTLFHTTVMTFENKYIFIPNGLLSSNVIINYSRMAVRRNEWIIGIEYNEDFDRVKTLLLRLIDEEPRIIKDPLPTVVLKELADSSVRVMARAWCATDDLWNVYWDINERIYSEFNRQGIAFPFPQLTIHGSAAGQERRGKSTEAQSPENVSTNTSL
>NC_015571.1|WP_004583632.1|245714_247511_+|chloride-channel-protein
MKDKETSRYGWFLHFLLWRERHINERLFLIILSLIIGILSAFAAVLLKNTIHIIQHFAFDRIRETSYLYLIFPVVGILITWLFVRYVVRDDIGHGVTKILFAISQRKSRIKPHNMWSSLAASSITIGFGGSVGAESPIVLTGAAIGSNLGRLFRMEQKTLMLLVGCGAAGAISGIFKAPITGLVFVIEVLLLDLTMSSVLPLLISSVSAAAVSYIITGQGAMFSFTLNDPFSMDRIPYALLLGVFCGLVSFYFSKVMFVFESKLKNFPHYRQRYLISAFILCGLIFLFPPLYGEGYDTINALLGGQYSSLMDGSLFEPYSNSYWVLFVFLGFIIITKVFASVATNSGGGCGGLFAPSLFMGALSGFIFAYALNFFPFIEVYLPQKNFALLGMAGVMAAVMHAPLTGIFLIAELTGGYNLFLPLMLVSTSSYATIRLFMPHSIYSLRLAQKGKLLTHQKDKAVLTLMTLDAVIEKDFEPVRPDMTLGDVVHVFGISHRNVFPVLDENNLLMGLVLLDNIRNIMFRPELYERFKVSRFMVSPPAKIVNTMSMETIMRIFDDTKAWNLPVIDEQGCYLGFVSKSKIFNSYREVLVETFSGD
>NC_015571.1|WP_013815252.1|244311_245718_+|sugar-transferase
MTRMQLHRLRYLLADVFGIVASYLSYNTLRYLTEEQERIYSTLSEYLFNAKSLWVGILYLLFWLSLFALSGYYNKPIAKSRISELLTTVASVLVGSVVVFLLLVVDDIVHDTALYLRLFFMMVATVLPWVYFPRLWVTTFGIKERKKTKGYHRVLLIGSGTIAEETASWLKSVNDMATTRLHFVPPTTREGFEQSLKSFATLVAEAVQESKPHQIILAVDCPDASFISLLLYQLYPFHMPVCVPMRSMLFAGAKVNVQGMKGEPMVDMTATNMSECAKSIKWFADRLFSLLMLILLIPVYAVIAVLVKRSSRGPVFFGQERIGLHGRPFTIYKFRTMYLDAEKDGPSLSFDGDSRVTPIGRILRKYRMDELPQFWNVLRGDMSFVGPRPERAFYIRQLVERAPYYYLLHNVRPGITSWGMVRYGYASTLDEMLERLQYDFLYYENMSLRLDIEVLLYTCQTIFKGLGK
>NC_015571.1|WP_013815251.1|243739_244315_+|threonylcarbamoyl-AMP-synthase
MLNDIQRSEAKKAAEVMRKGGIILYPTDTIWGIGCDATNEEAVRRIYRLKERADSKSMLVLIDSEAKLQGLMDEVPELAWDLIELTTKPLTIIYPQAKGVAPALIASDGSLGIRLTRETFSAELCRLMRVPIVSTSANISGQPSARTFGEIAPAILDGVDYIVECRREEPAGQASSIIRLGTRGEVEVIRQ
>NC_015571.1|WP_013815249.1|242704_243328_-|DNA-binding-protein
MAKFVMREMPDMQGTGKRTMYPKMISRGTMGLDEIADLISSQSTFSPGEVKGLVTALARTIAHGVASGYTVKIEEIGSFSASLTLHKGVEPEEAEGGTRRNAASVTIGGVNFRPDKALILEARTRVHLVRTTVRRPRRPNLTREERLALALRHLDGHSLLKVADYCRLTGLGRTAAAEELRAFDREGLIDSTGSGTHKVYIRNKAGI
>NC_015571.1|WP_004583625.1|240240_242508_-|inorganic-phosphate-transporter
MSLIFTAIVVFLFILAIFDLIVGVSNDAVNFLNSAIGAKAAPFKIIVGVAALGVFCGAAMNNGMMEIARHGIFRPEHYTFSELMVVFLSVVITDVVLMDMFNSLGMPTSTTVSLIFELLGGSFFMAMTKVGGTVGFQDLLNTEKALSVILGIFLSVGIAFFFGMVVQYLSRLLFTFNYRRNLRWLAGLFGGVAVTSIIYFMLIKGLKGVSFMTEESTAWIAANTGRLVLYCLVVSIILMQVLYWLRVNVFKVIVLLGTFALAMAFAGNDLVNFIGVPLAGYSSYLDFNANGNGQYGTYLMGALNEPASTPVYFLVAAGIVMVYALITSKKAHNVIKTSVDLARQEEGEEMFGSSGLARSIVRFSTTTANAVSRIIPRPVGRWIDSRFNQDELIMAKGAAFDLVRASVNLVLAGLLIAFGTSLRLPLSTTYVAFMVAMGTSLADRAWSRESAVFRITGVFSVIGGWFITAGAAFILCFLVTMVNHFGGYPAMAGMIILAIFLLVRSHIRFDKKKKSETKDTVFIDMMASHDKEEIWQLLAKHIRQKQLALLDFAENNYMQMTDGFINEDLKRLRRSINDQNAERQMLKVNRRKETLGIRRIEEAKSVVKNTWFHLGCNSCEQIVFCLKRIAEPCKEHVDNNFNPLPKVCVSEFLAAREKLILYIKEAKLIVSNETDEILDPMTYRGKDIKKELKQLRKTQLSRIQQGASSLKISLVYLNLLQESQQLVNILDDLIHATEKLFDPVARIGTDEEFFN
>NC_015571.1|WP_004583624.1|239778_240018_-|50S-ribosomal-protein-L28
MSKICQITGKKAMVGNNVSHSKRRTKRVFDVNLFRKKFYWVEQDCWVVLRISAAGLRLINKIGLDAAIKRAAEKGFLNA
>NC_015571.1|WP_004583623.1|239570_239759_-|50S-ribosomal-protein-L33
MAKKVKGNRVQVILECTEHKESGMPGISRYITTKNRKNTTQRLELKKYNPILRRMTLHKEIK
>NC_015571.1|WP_012458603.1|251474_252527_+|hypothetical-protein
MTVENLRLQRLQNLEHYRFAKNVLTLCRTANIAKLNPKLPELEKAIEMEDLALNPPVANELTPQVIALDEERDRAYQALMSRVRSYAFDEDSQLRNAAARIEDVAARYGNVIRMNYDKETAAIENFLTDLKGENIRPLVTKLGVTALVDRLEKNNKAFADFFLRRLSTDQRGKYDVKALRAETDRTLVAVVRRMDSIDDMEPSPEIRALIELYNRLVANRRALLARRASYGEAAVEKRRAEIAEMLRPLLARIVEEKKTAVFAGRTLGTGKNRHYLITFVAENGDEEDRWYRINGEQLVYVPEDELPKPKKKKKPASSTDTPSEPPVLPDPSQGGSSSGGGEQGSTGGGL
>NC_015571.1|WP_021662107.1|252670_253339_-|hypothetical-protein
METIRKITKWYLFVFALLAITIPSLAQETSKSEGLILSSSFRMGVPMLVSNLSLLDERAPLANNPGVAASVELSYKKFADRTSLGLLVDLGLYNNRIASFISGNNIGIENNVFNTFAGIVIRHYHIDNDRIELAAPIAIGYMHTWNFEDRQDLAGGVISRTKSMGAFAMTAGMELGFKVKEGKCIGAKVDLSAAVGKSMVDASKKMRCWLSPSIGLFFRHSL
>NC_015571.1|WP_021662106.1|253317_254409_-|hypothetical-protein
MQNAQSEKNLKIFFDGNKIFLLLPRISKFRIRRCRNIIPKYSKMKKSFVVGASLCIAAIFSLVSCSKQEIEEVRVMENETIKTDLPQARSIEDSVALAELVLDLETYNSSLDSDGRSTYSAGQQTFSVEGQLMNNRSFWSFFKKIAKAVAVVSADAIGVCVGSTIHPAMGVAFCATASAGTSVLLDADINVSFLKESFGPDITRSNYGVWHNNTIAAYLNEHGSLTNLDPLQFYNYSLTYCSNNIGSSTSRPLPYEKVETLCSALAQLFTSLENDNSEKTEEEICNMIVSAVPEIRAQEVKILLNFLLKMYSPDFKVEKRREYIAGHTEVVFQSRLSEAGKKRIYDMLSVACNSSLLWKQSEK
>NC_015571.1|WP_013815261.1|254621_255674_+|hypothetical-protein
MTAEIFSFSRLQNLEHYRFAKNVLTLCRTANIAKLNPKLPELEKAIEMEDLALNPPVANELTPQVIALDEERDRAYQALMSRVRSYAFDEDSKLRNAAARIEDVAARYGNVIRMNYDKETAAIENFLTDLKGENIRPLVTKLGVTALVDRLEKNNKAFADFFLRRLSTDQRGKYDVKALRAETDRTLVAVVRRMDSIDDMEPSPEIRALIELYNRLVANRRALLARRASYGEAAVEKRRAEIAEMLRPLLARIVEEKKTAVFAGRTLGTGKNRHYLITFVAENGDEEDRWYRINGEQLVYVPEDELPKPKKKKKPASSTDTPSEPPVLPDPSQGGSSSGGGEQGSTGGGL
>NC_015571.1|WP_013815262.1|256034_258038_-|hypothetical-protein
MKPLLTVVCAILLSLPLGGQTVVPEWDEYIAEQIESGALGEDEGAEFLERWMVQKQHPLDINTLTREDLEQFPFLNEFQIRRFLLYRHAHPEGFDSIWVLNEIAGWDRRTCLLLWPMLTVQKRSEPAVGSFREILSYARHDVSVHTDAILQRQEGYRPDSRHPYRGDPWGGGLRWSYAMGNRFSLGLTASKDRGEPAFDKRRKGFDSYSAHFFMEGKGAVRAVALGDYRIGMGYGLLVNQASFMGMAYAYPRGGTTLRRAFTYAEDNFMRGAATALAQGRWALTAFYSRKGVDATVTEDGAIKAIYHTGLHRTDAEIVRRNAATMTTAGTSVSYTDDRLRLTFNLLHLHWGGLRLLRAVGTQGIASLTDLERFSLVSADYSYLFGQGGTELFGEFAGAANGAVGTINGLRYTHPVGGSYMLVGRYIPADYWSYYRGAFARHSRPGNEWGVMGRAAWELPSDRTVRAFADYYGSFVPRFGRKEKTEALYWMFEGEKRLSALSWSCRIRGTADKRYRRSLAVRLRGRYTFDERWRLMASLQWSRSNSFDRELQTWQAPTGGKSFALRADYSGGKLLRLCSMDAVAFDTDSFADRLYEAVHNPRHHYSSAFFYGRGVRLGMFVRIAPLPHVEIESRTDHLLRRDTDTIGSAGELIRGQARTHLFMTVRYR
>NC_015571.1|WP_013815263.1|258067_258658_-|hypothetical-protein
MKRTLVFLFLTAVLALRAEAQSAPEQSETKDFIFSPQKEKVYVAIGYPAGIGLPSLDNYNVEGASASFAVGYERGVKQLAEGLLLSIYAELDWAAFRSVSDKRSLPFSDDSAQNRFRFLAGAGVHKRLNPNIELYARGAVGASFFPENNGSSSRELKGGFNVSLRVGLSCSLRDNFAVFIDTGTSDIVRGGLALMW
>NC_015571.1|WP_143733548.1|259241_259349_+|DUF1661-domain-containing-protein
MAREFFTSRTKTKKFPRHVFQSIDSLLQRVRYPLL
>NC_015571.1|WP_005874926.1|260353_260644_-|CRISPR-associated-endonuclease-Cas2
MNDKKLLVAYDISSNRRRRKVARILEQCGIRINKSVFICSLRELTMDKLVEAVTSQTAKRDKVFFLPLCQHCYTAAWMSGHPTLPKSRRKRKSIVV
>NC_015571.1|WP_013815267.1|260663_263759_-|CRISPR-associated-endonuclease-Cas1
MPLSTDSLPIFLSDFTAYHFSVRFRAERAIAFERKWYFMPRFALGNALKNSEQYAYLYGQIFKPQEEDTDESKGPGNTSRLIIRADKPSRKSLEAGEAMDLYITVVTRDPLLVGDFLSFLPEWQAYNFFRENDLTYDSYRLYNPTTQKYESGLRVEDAALTVDFFSRQAIRWGEILSVRFLSPASIKVDQILSAEIPYSRLMNRLSRRLYELYTQYLSRGETSVERYIFPDHDGLIYSQISMPRKATIKENRQYDMSGILGQLFYRVPYDPVAALMLSMAHWVHIGNHTIVGNGQIESTPCNDTLYRKWLSSLAADRDLPMAETERQDLLEALRICSYIPQPYHSVNIPKGDGSYRQLHIPSAVDLHLQRSLAGILYPITESLSIAQSYAYRKGKGAVAAVRRVQHLLDSLDENYTVVRCDIDNFFDSIPVPSLLQKVQRTTEDPLLTRMLSLWMKSGVVDRKQQYAPASSGIPQGSPLALLLSNLYLEDTDRYIAGHITTEFIRYADDLLLFLPEKVDPLNALQDLSEHLKYRKGLKLNRDFVVSSIKSSFSFLGITFCADGSRSMSRDKKEGLKRKITLALHRDTENFSALSETIHGMEQYYRKLLEKVDIEAIDEVAATVYATYIASLPTSEARKSAKDNLLRLGFLSSETAKQTLREAMRQTEVSSADNFPIKKESEILREQQKRQLQERGEIFDLVVTEPGAFIGISRNHVLVRKYGKTICKQPAAQIEQISIISDGVSLSSNVTKYCRKKNIRVIFYNATGQAYASLNGMNTILPSVMEAQMRLSEEKKREFILTLIKNKVRNQGKLLRYYHKYYRHDKELKEPLSNAIAELKQLEGIPIAEGSSLADFRQHAMLHEARCAQVYWRAFALLVHRSGHEFEGREHKGAEGLVNQMLNYGYAILRSYVMKTIDLWQLNPNIGILHSTQDNKPALCFDLMEQYRAFVVDRSILALLAKGEDVGQNNKGLLDMPTRSRIISKINERWFATEYYRSGEKLFSDIMKLQTKDVRAFCCGKVKRIKFYTPKW
>NC_015571.1|WP_013815268.1|263820_264594_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MNFGHWYYREYFDTINLDSKGIVTNFSTFNKGKNDKLIKGATLPPYDKENDIEDVTSFELKTCYPGLLCGVGYHHEINNPKNEPKEDDAPEVYNLGMYFDYTSGLPVIPGSSIKGMLRSAIEEWDFLADYKPQEKNTPPASLSDKKVLHEEIIKTVFEGKGLSIYDRDIFLDAIPIRVDNKLFGEDYITHHPTPLQNPNPVRFLRVNPGVTYQFRFILRNNDNGLKADFKEDLFKAIICTFGLGAKTNVGYGQFVEH

Crispr_ID: NC_015571_4

• CRISPR_ID: NC_015571_4
• CRISPR_location: 259611-259953
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 4 spacers
• Cas_protein_info: cas2,cas1,cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7

Consensus repeat of NC_015571_4

Consensus_repeat	Method
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	PILER-CR
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CRISPRCasFinder
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CRT

spacers of NC_015571_4

>4.1|259648|43|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CCAAAACTGCTAAGGCTGCAGCTCAGAATGCACTAGACCAGTT
>4.2|259728|39|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TATAGTTCAAGCTTCTGATACAGACTTGATTGAAGAAGA
>4.3|259804|41|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CGGGAGTGCGACAAGATACTTGGCTCCGGCCGCACGATTGG
>4.4|259882|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CGTATATCCGGCATTAGTAGGAGAGGTTATGATAA

CRISPR arrays and Neighbor proteins around NC_015571_4

CRISPR arrays

The CRISPR arrays of NC_015571_4

>merge|NC_015571|4|259611-259953|PILER-CR,CRISPRCasFinder,CRT
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAGCCAAAACTGCTAAGGCTGCAGCTCAGAATGCACTAGACCAGTTGTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAGTATAGTTCAAGCTTCTGATACAGACTTGATTGAAGAAGAGTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAGCGGGAGTGCGACAAGATACTTGGCTCCGGCCGCACGATTGGGTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAGCGTATATCCGGCATTAGTAGGAGAGGTTATGATAAGTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG

>NC_015571|4|1|259611-259953|PILER-CR
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CCAAAACTGCTAAGGCTGCAGCTCAGAATGCACTAGACCAGTT
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	TATAGTTCAAGCTTCTGATACAGACTTGATTGAAGAAGA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGGGAGTGCGACAAGATACTTGGCTCCGGCCGCACGATTGG
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGTATATCCGGCATTAGTAGGAGAGGTTATGATAA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG

>NC_015571|4|4|259611-259953|CRISPRCasFinder
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CCAAAACTGCTAAGGCTGCAGCTCAGAATGCACTAGACCAGTT
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	TATAGTTCAAGCTTCTGATACAGACTTGATTGAAGAAGA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGGGAGTGCGACAAGATACTTGGCTCCGGCCGCACGATTGG
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGTATATCCGGCATTAGTAGGAGAGGTTATGATAA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG

>NC_015571|4|1|259611-259953|CRT
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CCAAAACTGCTAAGGCTGCAGCTCAGAATGCACTAGACCAGTT
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	TATAGTTCAAGCTTCTGATACAGACTTGATTGAAGAAGA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGGGAGTGCGACAAGATACTTGGCTCCGGCCGCACGATTGG
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG	CGTATATCCGGCATTAGTAGGAGAGGTTATGATAA
GTCTTAATAGCCTTACGGACTGTGTATGTATAGTGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_013815261.1|254621_255674_+|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815267.1|260663_263759_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187766
NC_015571.1|WP_013815270.1|265024_265726_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl|CDD|187813
NC_015571.1|WP_013815272.1|266952_268602_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	gnl|CDD|274208
NC_015571.1|WP_013815256.1|249966_250869_-|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|275036
NC_015571.1|WP_143733548.1|259241_259349_+|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_005874934.1|270052_270304_-|hypothetical-protein	cmr1gr7	mkCas0102_cmr1gr7_CAS-III-B	unknown
NC_015571.1|WP_012458603.1|251474_252527_+|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815273.1|268594_270046_-|hypothetical-protein	cmr1gr7	mkCas0086_cmr1gr7_CAS-III-B	unknown
NC_015571.1|WP_005874926.1|260353_260644_-|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl|CDD|187856
NC_015571.1|WP_005874939.1|270305_271889_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815253.1|247471_248536_-|mechanosensitive-ion-channel	unknown	unknown	gnl|CDD|182386
NC_015571.1|WP_013815269.1|264590_265028_-|hypothetical-protein	cmr5gr11	mkCas0098_cmr5gr11_CAS-III-B	unknown
NC_015571.1|WP_013815271.1|265739_266951_-|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	cd09656_cmr3gr5_CAS-III-B	gnl|CDD|273855
NC_015571.1|WP_021662107.1|252670_253339_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815268.1|263820_264594_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	gnl|CDD|187792
NC_015571.1|WP_013815254.1|248572_249460_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NC_015571.1|WP_013815262.1|256034_258038_-|hypothetical-protein	unknown	unknown	gnl|CDD|378965
NC_015571.1|WP_013815263.1|258067_258658_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_021662106.1|253317_254409_-|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_015571.1|WP_013815267.1|260663_263759_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	3.4e-64	211.5	0.3
NC_015571.1|WP_013815273.1|268594_270046_-|hypothetical-protein	cmr1gr7	mkCas0086_cmr1gr7_CAS-III-B	1.5e-94	312.1	17.2
NC_015571.1|WP_013815272.1|266952_268602_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	4.7e-102	337.1	17.0
NC_015571.1|WP_013815269.1|264590_265028_-|hypothetical-protein	cmr5gr11	mkCas0098_cmr5gr11_CAS-III-B	4.6e-68	222.5	0.8
NC_015571.1|WP_013815271.1|265739_266951_-|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	cd09656_cmr3gr5_CAS-III-B	5.3e-79	260.5	4.4
NC_015571.1|WP_005874934.1|270052_270304_-|hypothetical-protein	cmr1gr7	mkCas0102_cmr1gr7_CAS-III-B	2e-49	160.7	5.4
NC_015571.1|WP_013815270.1|265024_265726_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	2.7e-67	222.0	0.0
NC_015571.1|WP_005874926.1|260353_260644_-|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	8.1e-20	65.7	0.2
NC_015571.1|WP_013815268.1|263820_264594_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	3.2e-59	194.9	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_013815267.1|260663_263759_-|CRISPR-associated-endonuclease-Cas1	gnl|CDD|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.81881e-68
NC_015571.1|WP_013815253.1|247471_248536_-|mechanosensitive-ion-channel	gnl|CDD|182386	PRK10334, PRK10334, small-conductance mechanosensitive channel MscS.	1.49128e-59
NC_015571.1|WP_013815272.1|266952_268602_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl|CDD|274208	TIGR02577, thermophile-specific_DNA_repair_system, CRISPR-associated protein Cas10/Cmr2, subtype III-B. This model represent a Crm2 family of the CRISPR-associated RAMP module, a set of six genes recurring found together in prokaryotic genomes. This gene cluster is found only in species with CRISPR repeats, usually near the repeats themselves. Because most of the six (but not this family) contain RAMP domains, and because its appearance in a genome appears to depend on other CRISPR-associated Cas genes, the set is designated the CRISPR RAMP module. This protein, typified by TM1794 from Thermotoga maritima, is designated Crm2, for CRISPR RAMP Module protein 2.	1.75135e-95
NC_015571.1|WP_013815256.1|249966_250869_-|T9SS-type-A-sorting-domain-containing-protein	gnl|CDD|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	3.30199e-10
NC_015571.1|WP_013815271.1|265739_266951_-|type-III-B-CRISPR-module-associated-protein-Cmr3	gnl|CDD|273855	TIGR01888, Hypothetical_protein_SSO1730, CRISPR type III-B/RAMP module-associated protein Cmr3. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family is found in at least ten different archaeal and bacterial species as part of the CRISPR RAMP modulue but is not a member of the RAMP superfamily itself. A typical example is TM1793 from Thermotoga maritima.	6.74082e-71
NC_015571.1|WP_143733548.1|259241_259349_+|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.000634986
NC_015571.1|WP_013815270.1|265024_265726_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl|CDD|187813	cd09682, Cmr4_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	3.5941e-85
NC_015571.1|WP_013815254.1|248572_249460_+|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.69614e-15
NC_015571.1|WP_013815262.1|256034_258038_-|hypothetical-protein	gnl|CDD|378965	pfam12836, HHH_3, Helix-hairpin-helix motif. The HhH domain is a short DNA-binding domain.	0.000696007
NC_015571.1|WP_005874926.1|260353_260644_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	8.2336e-16
NC_015571.1|WP_013815268.1|263820_264594_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6	gnl|CDD|187792	cd09661, Cmr6_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.45991e-60

Protein sequences

>NC_015571.1|WP_143733548.1|259241_259349_+|DUF1661-domain-containing-protein
MAREFFTSRTKTKKFPRHVFQSIDSLLQRVRYPLL
>NC_015571.1|WP_013815263.1|258067_258658_-|hypothetical-protein
MKRTLVFLFLTAVLALRAEAQSAPEQSETKDFIFSPQKEKVYVAIGYPAGIGLPSLDNYNVEGASASFAVGYERGVKQLAEGLLLSIYAELDWAAFRSVSDKRSLPFSDDSAQNRFRFLAGAGVHKRLNPNIELYARGAVGASFFPENNGSSSRELKGGFNVSLRVGLSCSLRDNFAVFIDTGTSDIVRGGLALMW
>NC_015571.1|WP_013815262.1|256034_258038_-|hypothetical-protein
MKPLLTVVCAILLSLPLGGQTVVPEWDEYIAEQIESGALGEDEGAEFLERWMVQKQHPLDINTLTREDLEQFPFLNEFQIRRFLLYRHAHPEGFDSIWVLNEIAGWDRRTCLLLWPMLTVQKRSEPAVGSFREILSYARHDVSVHTDAILQRQEGYRPDSRHPYRGDPWGGGLRWSYAMGNRFSLGLTASKDRGEPAFDKRRKGFDSYSAHFFMEGKGAVRAVALGDYRIGMGYGLLVNQASFMGMAYAYPRGGTTLRRAFTYAEDNFMRGAATALAQGRWALTAFYSRKGVDATVTEDGAIKAIYHTGLHRTDAEIVRRNAATMTTAGTSVSYTDDRLRLTFNLLHLHWGGLRLLRAVGTQGIASLTDLERFSLVSADYSYLFGQGGTELFGEFAGAANGAVGTINGLRYTHPVGGSYMLVGRYIPADYWSYYRGAFARHSRPGNEWGVMGRAAWELPSDRTVRAFADYYGSFVPRFGRKEKTEALYWMFEGEKRLSALSWSCRIRGTADKRYRRSLAVRLRGRYTFDERWRLMASLQWSRSNSFDRELQTWQAPTGGKSFALRADYSGGKLLRLCSMDAVAFDTDSFADRLYEAVHNPRHHYSSAFFYGRGVRLGMFVRIAPLPHVEIESRTDHLLRRDTDTIGSAGELIRGQARTHLFMTVRYR
>NC_015571.1|WP_013815261.1|254621_255674_+|hypothetical-protein
MTAEIFSFSRLQNLEHYRFAKNVLTLCRTANIAKLNPKLPELEKAIEMEDLALNPPVANELTPQVIALDEERDRAYQALMSRVRSYAFDEDSKLRNAAARIEDVAARYGNVIRMNYDKETAAIENFLTDLKGENIRPLVTKLGVTALVDRLEKNNKAFADFFLRRLSTDQRGKYDVKALRAETDRTLVAVVRRMDSIDDMEPSPEIRALIELYNRLVANRRALLARRASYGEAAVEKRRAEIAEMLRPLLARIVEEKKTAVFAGRTLGTGKNRHYLITFVAENGDEEDRWYRINGEQLVYVPEDELPKPKKKKKPASSTDTPSEPPVLPDPSQGGSSSGGGEQGSTGGGL
>NC_015571.1|WP_021662106.1|253317_254409_-|hypothetical-protein
MQNAQSEKNLKIFFDGNKIFLLLPRISKFRIRRCRNIIPKYSKMKKSFVVGASLCIAAIFSLVSCSKQEIEEVRVMENETIKTDLPQARSIEDSVALAELVLDLETYNSSLDSDGRSTYSAGQQTFSVEGQLMNNRSFWSFFKKIAKAVAVVSADAIGVCVGSTIHPAMGVAFCATASAGTSVLLDADINVSFLKESFGPDITRSNYGVWHNNTIAAYLNEHGSLTNLDPLQFYNYSLTYCSNNIGSSTSRPLPYEKVETLCSALAQLFTSLENDNSEKTEEEICNMIVSAVPEIRAQEVKILLNFLLKMYSPDFKVEKRREYIAGHTEVVFQSRLSEAGKKRIYDMLSVACNSSLLWKQSEK
>NC_015571.1|WP_021662107.1|252670_253339_-|hypothetical-protein
METIRKITKWYLFVFALLAITIPSLAQETSKSEGLILSSSFRMGVPMLVSNLSLLDERAPLANNPGVAASVELSYKKFADRTSLGLLVDLGLYNNRIASFISGNNIGIENNVFNTFAGIVIRHYHIDNDRIELAAPIAIGYMHTWNFEDRQDLAGGVISRTKSMGAFAMTAGMELGFKVKEGKCIGAKVDLSAAVGKSMVDASKKMRCWLSPSIGLFFRHSL
>NC_015571.1|WP_012458603.1|251474_252527_+|hypothetical-protein
MTVENLRLQRLQNLEHYRFAKNVLTLCRTANIAKLNPKLPELEKAIEMEDLALNPPVANELTPQVIALDEERDRAYQALMSRVRSYAFDEDSQLRNAAARIEDVAARYGNVIRMNYDKETAAIENFLTDLKGENIRPLVTKLGVTALVDRLEKNNKAFADFFLRRLSTDQRGKYDVKALRAETDRTLVAVVRRMDSIDDMEPSPEIRALIELYNRLVANRRALLARRASYGEAAVEKRRAEIAEMLRPLLARIVEEKKTAVFAGRTLGTGKNRHYLITFVAENGDEEDRWYRINGEQLVYVPEDELPKPKKKKKPASSTDTPSEPPVLPDPSQGGSSSGGGEQGSTGGGL
>NC_015571.1|WP_013815256.1|249966_250869_-|T9SS-type-A-sorting-domain-containing-protein
MAFAQVPKGNDKSKDEHILTWALPEELVIDNNSIVATYNSFLTPFNGMTMACASFFDVQDLLPYVGYTINRIDFHPTADEKNYEQVAASKFYICIWGNKEQTEVLYEQALPTIHKEDLSFGYGVDGEEDYYDEPMYLAELETPFVIPAGKALYIGCRVETQEGHAVGFGLDDGPAMKGKGDLVGSYLPGAAPMPFVPLSDIPARSMDANFFIYSRISLGSGTQDILQHRMKVYPNPATTELHVEALSAWVGEQAAVYDMRGRRVSARMVDSEKLCIDIASLPAGVYVLRIGSYSAKFEKR
>NC_015571.1|WP_013815254.1|248572_249460_+|tetratricopeptide-repeat-protein
MTDRFLHILRLSALCLLFSALLPPLFGQPTTTRQDSLPADYTRLIDRSFEALGQGNLELAEQALRQAIKAYPDLPSGYALMNNLGAIQQRQGKPEEALLTYSAALQKLPDDKLLRTNRAMLLTEMGRTDEAIFDYNELLRAEPDNEIFHYGRAMLYLAKGMYGDAESDLEEILRVNDSSLKARLGIALVATMKGEYDKAERLYNYVIDKLPKNAAAYEGRARLFLNKGMKGYALRDINKAFEYATPPAASLFVLRGEINAAIGDKKAAAEDYAVAESRGYSKESLDLLRAALRKQ
>NC_015571.1|WP_013815253.1|247471_248536_-|mechanosensitive-ion-channel
MPADSVSAGLSASINDIKVTNRMGLKIFFPLQNLSVDTTKVNKIAEVVSPEALKQIKEIKPSQWTELLTQWGGKALSFGIKVLIALVAFYLGKLLLNALVKWLDRIMVRRSFEPAARTFLRSFANIGGFVLLIVIIISTLGFQPVSLAALLASVGVAVGMGLSGQLQNLAGGLIVLLTKPFKVGDYIVSNNVEGVVDGVTLFHTTVMTFENKYIFIPNGLLSSNVIINYSRMAVRRNEWIIGIEYNEDFDRVKTLLLRLIDEEPRIIKDPLPTVVLKELADSSVRVMARAWCATDDLWNVYWDINERIYSEFNRQGIAFPFPQLTIHGSAAGQERRGKSTEAQSPENVSTNTSL
>NC_015571.1|WP_005874926.1|260353_260644_-|CRISPR-associated-endonuclease-Cas2
MNDKKLLVAYDISSNRRRRKVARILEQCGIRINKSVFICSLRELTMDKLVEAVTSQTAKRDKVFFLPLCQHCYTAAWMSGHPTLPKSRRKRKSIVV
>NC_015571.1|WP_013815267.1|260663_263759_-|CRISPR-associated-endonuclease-Cas1
MPLSTDSLPIFLSDFTAYHFSVRFRAERAIAFERKWYFMPRFALGNALKNSEQYAYLYGQIFKPQEEDTDESKGPGNTSRLIIRADKPSRKSLEAGEAMDLYITVVTRDPLLVGDFLSFLPEWQAYNFFRENDLTYDSYRLYNPTTQKYESGLRVEDAALTVDFFSRQAIRWGEILSVRFLSPASIKVDQILSAEIPYSRLMNRLSRRLYELYTQYLSRGETSVERYIFPDHDGLIYSQISMPRKATIKENRQYDMSGILGQLFYRVPYDPVAALMLSMAHWVHIGNHTIVGNGQIESTPCNDTLYRKWLSSLAADRDLPMAETERQDLLEALRICSYIPQPYHSVNIPKGDGSYRQLHIPSAVDLHLQRSLAGILYPITESLSIAQSYAYRKGKGAVAAVRRVQHLLDSLDENYTVVRCDIDNFFDSIPVPSLLQKVQRTTEDPLLTRMLSLWMKSGVVDRKQQYAPASSGIPQGSPLALLLSNLYLEDTDRYIAGHITTEFIRYADDLLLFLPEKVDPLNALQDLSEHLKYRKGLKLNRDFVVSSIKSSFSFLGITFCADGSRSMSRDKKEGLKRKITLALHRDTENFSALSETIHGMEQYYRKLLEKVDIEAIDEVAATVYATYIASLPTSEARKSAKDNLLRLGFLSSETAKQTLREAMRQTEVSSADNFPIKKESEILREQQKRQLQERGEIFDLVVTEPGAFIGISRNHVLVRKYGKTICKQPAAQIEQISIISDGVSLSSNVTKYCRKKNIRVIFYNATGQAYASLNGMNTILPSVMEAQMRLSEEKKREFILTLIKNKVRNQGKLLRYYHKYYRHDKELKEPLSNAIAELKQLEGIPIAEGSSLADFRQHAMLHEARCAQVYWRAFALLVHRSGHEFEGREHKGAEGLVNQMLNYGYAILRSYVMKTIDLWQLNPNIGILHSTQDNKPALCFDLMEQYRAFVVDRSILALLAKGEDVGQNNKGLLDMPTRSRIISKINERWFATEYYRSGEKLFSDIMKLQTKDVRAFCCGKVKRIKFYTPKW
>NC_015571.1|WP_013815268.1|263820_264594_-|type-III-B-CRISPR-module-RAMP-protein-Cmr6
MNFGHWYYREYFDTINLDSKGIVTNFSTFNKGKNDKLIKGATLPPYDKENDIEDVTSFELKTCYPGLLCGVGYHHEINNPKNEPKEDDAPEVYNLGMYFDYTSGLPVIPGSSIKGMLRSAIEEWDFLADYKPQEKNTPPASLSDKKVLHEEIIKTVFEGKGLSIYDRDIFLDAIPIRVDNKLFGEDYITHHPTPLQNPNPVRFLRVNPGVTYQFRFILRNNDNGLKADFKEDLFKAIICTFGLGAKTNVGYGQFVEH
>NC_015571.1|WP_013815269.1|264590_265028_-|hypothetical-protein
MNKKTIQDLIPKAMQAIEGVGIVGKDKKFKKVHEGYINALGPNIIQSGLLPTLIFYNKDERALWLRALYYMAVGEEDEMTDESSTVIIRLIIGKEGGRIENLKPKAKEWERKILEYAVALKLALRTFVAEEAETSNTKQQEGGAQ
>NC_015571.1|WP_013815270.1|265024_265726_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MKTAAYMIHCLTNMHVGKGDATYEVVDKCVQRDVTTGMPCIYSSSLKGALRQFFSKQGFAELNYVFGKDQSRDKKNNGNEKNEEEHSVGNFTFFQANLLAYPVQTTREGATYILKTNKALQESIKELAKLLSAPSNIEDLLPEGIEKDLSNEALEQLPVIARNQLDNGKSENLWYEEVVPAESRFVFFVSYDDEEIFAKFDKIIQEKVIQIGANGSIGYGFCKIANVTNPFKK
>NC_015571.1|WP_013815271.1|265739_266951_-|type-III-B-CRISPR-module-associated-protein-Cmr3
MSTYLIKLTPLDKFFFGQKKTFGDDNANYFVYSSHFPQQTALLGLLRYQLLQIAGEEIFKDNKIQDEHKAGELIGKQSFSPFVKDKLQFGIIQSLSPVFIIDKKKDEGKEEYFLPVGKRFQKKKEKAPYSLLHLSCEDECPPIFESRESQKEKEEAYDPKKGLASCWLSSKSHTLLNEEDFFTKDERIGIRKDYEGATNDDAFFCQRYYRFKNFKKVVEDEEGNECKQPPVRVHDFCFATVLETEKAIEHEKLNGKIVYLGGERQPFLMEVSEETFKLNIESSTLTSDEKHYTVVLLSDAMIDPDHLSKVRFASTEVKDFACLLTHVGTQKFYNKENKRQEQYLKKSATALSLQKELYARGSVFYFDTKEQANQFCEDLEKVPNFHTIGYNHAIIIEPTKTKK
>NC_015571.1|WP_013815272.1|266952_268602_-|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MSNEIYTAITIGPICKTLDKARSVKSFWTASYLFSWIMRELLERLPKEERPEGSFEVLSPHRDGKDVPEETSKKVGLFPDRLFAKGELEEEKLQEIKGKIFIELAEKFKNAFQDEKDGITRKIDTESDPKRKRELEEIQSRYSNAALKGEDIRKYLENYLSISCITVELSSDCNILEQLNSYLDTQELFNKASIQTDEDYMELFIEAPNNTFLKAYSQDRAFPSTSEIAVSGWEQDPPKDENGEVEYTQLTSKPGFRNCYKYLAVIKADGDGFGTYIKELKVDEEKEIKENGEKENELSRFTKSFFEFSVEVANELIQKTKAIPVYIGGDDLFLFAPVLEGNVEKDVFNLIKEIDDLFIQKEIGEGLSMSYGVSIFYYKSPMSEAIDIADSMLRKAKEEKEEKEKKKDAVAISIQKHSGQKIEFLLPCKHSSADETDRKESLYGKTVELVRAFKGDGNMLNSLIYWIEEMYEILFIEEVTQSQERINAVFDNFFDEEIHKENEVFFDLLKDFIHSMHRSEDAPRKLSDKKELLHGILRYCQFVTAKKEK
>NC_015571.1|WP_013815273.1|268594_270046_-|hypothetical-protein
MYKLEFELEQHTPIIHFQARDAGATLRASEVKPKLDKFILTQIGKRFVKKTASTTEKNFIERGIEYFQNKDEEARRVYEEEKKKGNKDAKLELCLIPGQEGALNYKLSFKLSPDAKVQYFLPMSSNPKEIDKLKSLAQEKLGVQGVEILPLTSYFANEDKAKSEPNIKRGDTPSQIKNKKRIFEKNWQKVQLATFVNTPVEGVIRFQNAGLREEVNNLITNFFMLHNFGARQSKGFGSFIISLRDGKEEEDYFDTGCACYGYSFYIPAKTLEEALRKINYFYRSLRSGFNEYRGKNEIFYAKSGMHFYATKHNFEWDKKSIKGMLFDRDKDLEGKMKKEELFAFRDLLGLSSNERWQSYKTTITKECRNKKGEKFDRIKSPIQFKPICYSKYDYIVFFDLFPEKSGIPQLKGGKVVVKSSRHKGAVLELKIQEDIDLYNVFNEIFSELNFESQVGEYDSLTDAKEIFETMKDIYEQLNKNCHE
>NC_015571.1|WP_005874934.1|270052_270304_-|hypothetical-protein
MEIETLILLCFVVVATATIIVVAIIWSYKLKIKKEELRDKTLFELERERTKDLNKWQSFSESLLETNKGLMEVYCKDNTKQKA
>NC_015571.1|WP_005874939.1|270305_271889_-|hypothetical-protein
MEAETYSRHIFIFPFQWDYIEKRGYASYNERTDIKKFDKLFSAVSPLKRQYFEIGASEERYNEYTYFHPFARRALFGTKENPSVYHYELSDTQGSYNISVKIDGVSTTYSLQLEKIAVSVFDTGVGTVAYFLRNDKHTSFEDILRINDSGRRIYPQYMAKGDRLAAKNSFLADRIYGSLGVLDFDDDFRQFEEDISHTNIFLPPDHIRQVFGYNKMDRTEDDGCQKFVFHQESERKDIIRISPVMDDRMFFITYYHSPYYAKKLRSKPKNFRRKREYNIYEEGRFGDLWFRYIFGDRGDKTVANTSVQREDVRRTTYARWSGEGTLFGLTKDSLVGISGWELMGDHITTMYYQMATLSLVQRSTILRFSNEIASITQLILDKKTKRKTEKQVKELYGNYIRFLNETYFREVTPQIQGIEMYDMLQSNMNIEKDAKALDEEMGELFNYTTLEEQGVLNKTANLYLPITLLVGFLGINTFVEKGCITRFFNIGDPCPSTWGLLGGDIITLIVFAICLYFPIRHYFKYRK

Crispr_ID: NC_015571_5

• CRISPR_ID: NC_015571_5
• CRISPR_location: 293621-294703
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 16 spacers
• Cas_protein_info: cas2,cas1,cas4,cas3,cas7b,cas8b4,cas5,cas6

Consensus repeat of NC_015571_5

Consensus_repeat	Method
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CRISPRCasFinder
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CRT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	PILER-CR

spacers of NC_015571_5

>5.1|293651|36|NC_015571|CRISPRCasFinder,CRT
GGGGATGAGCGGCGATGGCTTAATCGGGCGTCTGTT
>5.2|293717|37|NC_015571|CRISPRCasFinder,CRT
TTGCATACCGACCTCTTCCAACGAGCCTGCATCGCTC
>5.3|293784|37|NC_015571|CRISPRCasFinder,CRT
TTCCAGCCTGCAGACGACAAAGCAGGCGCCTCGAAGG
>5.4|293851|36|NC_015571|CRISPRCasFinder,CRT
GGCGTACCCCCTATGACAGCTACCCGGCTACTCATC
>5.5|293917|37|NC_015571|CRISPRCasFinder,CRT
GATAACTGGTTCGAGGAGTACGAGCGTAATATGGATA
>5.6|293984|36|NC_015571|CRISPRCasFinder,CRT
GGGGGGCGGGCAGCACGGCGGTGATCTGCTTTTCGG
>5.7|294050|36|NC_015571|CRISPRCasFinder,CRT
ACGATCGCCGGCGAGGATCTTACCGGTTACACGGTA
>5.8|294116|34|NC_015571|CRISPRCasFinder,CRT
CGGAATGCTACTTACTATGCGCGCGCATCCTCGC
>5.9|294180|36|NC_015571|CRISPRCasFinder,CRT
GACGTTTATCTTATAGTCGAATTGATTGCTCATTGT
>5.10|294246|34|NC_015571|CRISPRCasFinder,CRT
GAACAAGCTGGTCGTTCAGAATCATTATCACTTT
>5.11|294310|36|NC_015571|CRISPRCasFinder,CRT
CGGTAGCGAAAACTACTTTTTATTTCAGGACAAAGA
>5.12|294376|37|NC_015571|CRISPRCasFinder,CRT
TCTTCATAGAACTGTTGTTTATTAGTGATGATATGTT
>5.13|294443|35|NC_015571|CRISPRCasFinder,CRT
TGAGCTATTTCTTTGTCGTCTTGTCTTGAGACTTG
>5.14|294508|34|NC_015571|CRISPRCasFinder,CRT
TAGAACATACTATTAATAATACATCAAGAACATC
>5.15|294572|37|NC_015571|CRISPRCasFinder,CRT
AATCGGCGCAAAGGACTACGCCGCCGGCAACCACGGC
>5.16|294639|35|NC_015571|CRISPRCasFinder,CRT
TTCGCTCCCTTTTTAACCCCGAGCGCGGGCATATT
>5.17|293652|36|NC_015571|PILER-CR
GGGGATGAGCGGCGATGGCTTAATCGGGCGTCTGTT
>5.18|293718|37|NC_015571|PILER-CR
TTGCATACCGACCTCTTCCAACGAGCCTGCATCGCTC
>5.19|293785|37|NC_015571|PILER-CR
TTCCAGCCTGCAGACGACAAAGCAGGCGCCTCGAAGG
>5.20|293852|36|NC_015571|PILER-CR
GGCGTACCCCCTATGACAGCTACCCGGCTACTCATC
>5.21|293918|37|NC_015571|PILER-CR
GATAACTGGTTCGAGGAGTACGAGCGTAATATGGATA
>5.22|293985|36|NC_015571|PILER-CR
GGGGGGCGGGCAGCACGGCGGTGATCTGCTTTTCGG
>5.23|294051|36|NC_015571|PILER-CR
ACGATCGCCGGCGAGGATCTTACCGGTTACACGGTA
>5.24|294117|34|NC_015571|PILER-CR
CGGAATGCTACTTACTATGCGCGCGCATCCTCGC
>5.25|294181|36|NC_015571|PILER-CR
GACGTTTATCTTATAGTCGAATTGATTGCTCATTGT
>5.26|294247|34|NC_015571|PILER-CR
GAACAAGCTGGTCGTTCAGAATCATTATCACTTT
>5.27|294311|36|NC_015571|PILER-CR
CGGTAGCGAAAACTACTTTTTATTTCAGGACAAAGA
>5.28|294377|37|NC_015571|PILER-CR
TCTTCATAGAACTGTTGTTTATTAGTGATGATATGTT
>5.29|294444|35|NC_015571|PILER-CR
TGAGCTATTTCTTTGTCGTCTTGTCTTGAGACTTG
>5.30|294509|34|NC_015571|PILER-CR
TAGAACATACTATTAATAATACATCAAGAACATC
>5.31|294573|37|NC_015571|PILER-CR
AATCGGCGCAAAGGACTACGCCGCCGGCAACCACGGC
>5.32|294640|35|NC_015571|PILER-CR
TTCGCTCCCTTTTTAACCCCGAGCGCGGGCATATT

CRISPR arrays and Neighbor proteins around NC_015571_5

CRISPR arrays

The CRISPR arrays of NC_015571_5

>merge|NC_015571|5|293621-294703|CRISPRCasFinder,CRT,PILER-CR
ATTTTAATTCCTGTATGGTGCAATTGAAATGGGGATGAGCGGCGATGGCTTAATCGGGCGTCTGTTGTTTTAATTCCTGTATGGTGCAATTGAAATTTGCATACCGACCTCTTCCAACGAGCCTGCATCGCTCGTTTTAATTCCTGTATGGTGCAATTGAAATTTCCAGCCTGCAGACGACAAAGCAGGCGCCTCGAAGGGTTTTAATTCCTGTATGGTGCAATTGAAATGGCGTACCCCCTATGACAGCTACCCGGCTACTCATCGTTTTAATTCCTGTATGGTGCAATTGAAATGATAACTGGTTCGAGGAGTACGAGCGTAATATGGATAGTTTTAATTCCTGTATGGTGCAATTGAAATGGGGGGCGGGCAGCACGGCGGTGATCTGCTTTTCGGGTTTTAATTCCTGTATGGTGCAATTGAAATACGATCGCCGGCGAGGATCTTACCGGTTACACGGTAGTTTTAATTCCTGTATGGTGCAATTGAAATCGGAATGCTACTTACTATGCGCGCGCATCCTCGCGTTTTAATTCCTGTATGGTGCAATTGAAATGACGTTTATCTTATAGTCGAATTGATTGCTCATTGTGTTTTAATTCCTGTATGGTGCAATTGAAATGAACAAGCTGGTCGTTCAGAATCATTATCACTTTGTTTTAATTCCTGTATGGTGCAATTGAAATCGGTAGCGAAAACTACTTTTTATTTCAGGACAAAGAGTTTTAATTCCTGTATGGTGCAATTGAAATTCTTCATAGAACTGTTGTTTATTAGTGATGATATGTTGTTTTAATTCCTGTATGGTGCAATTGAAATTGAGCTATTTCTTTGTCGTCTTGTCTTGAGACTTGGTTTTAATTCCTGTATGGTGCAATTGAAATTAGAACATACTATTAATAATACATCAAGAACATCGTTTTAATTCCTGTATGGTGCAATTGAAATAATCGGCGCAAAGGACTACGCCGCCGGCAACCACGGCGTTTTAATTCCTGTATGGTGCAATTGAAATTTCGCTCCCTTTTTAACCCCGAGCGCGGGCATATTGTTTTAATTCCTGTATGGTGCAATTGAAAT

>NC_015571|5|5|293621-294703|CRISPRCasFinder
ATTTTAATTCCTGTATGGTGCAATTGAAAT	GGGGATGAGCGGCGATGGCTTAATCGGGCGTCTGTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTGCATACCGACCTCTTCCAACGAGCCTGCATCGCTC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCCAGCCTGCAGACGACAAAGCAGGCGCCTCGAAGG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GGCGTACCCCCTATGACAGCTACCCGGCTACTCATC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GATAACTGGTTCGAGGAGTACGAGCGTAATATGGATA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GGGGGGCGGGCAGCACGGCGGTGATCTGCTTTTCGG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGATCGCCGGCGAGGATCTTACCGGTTACACGGTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGGAATGCTACTTACTATGCGCGCGCATCCTCGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GACGTTTATCTTATAGTCGAATTGATTGCTCATTGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GAACAAGCTGGTCGTTCAGAATCATTATCACTTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGGTAGCGAAAACTACTTTTTATTTCAGGACAAAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TCTTCATAGAACTGTTGTTTATTAGTGATGATATGTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGAGCTATTTCTTTGTCGTCTTGTCTTGAGACTTG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAGAACATACTATTAATAATACATCAAGAACATC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AATCGGCGCAAAGGACTACGCCGCCGGCAACCACGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCGCTCCCTTTTTAACCCCGAGCGCGGGCATATT
GTTTTAATTCCTGTATGGTGCAATTGAAAT

>NC_015571|5|2|293621-294703|CRT
ATTTTAATTCCTGTATGGTGCAATTGAAAT	GGGGATGAGCGGCGATGGCTTAATCGGGCGTCTGTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTGCATACCGACCTCTTCCAACGAGCCTGCATCGCTC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCCAGCCTGCAGACGACAAAGCAGGCGCCTCGAAGG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GGCGTACCCCCTATGACAGCTACCCGGCTACTCATC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GATAACTGGTTCGAGGAGTACGAGCGTAATATGGATA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GGGGGGCGGGCAGCACGGCGGTGATCTGCTTTTCGG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGATCGCCGGCGAGGATCTTACCGGTTACACGGTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGGAATGCTACTTACTATGCGCGCGCATCCTCGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GACGTTTATCTTATAGTCGAATTGATTGCTCATTGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GAACAAGCTGGTCGTTCAGAATCATTATCACTTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGGTAGCGAAAACTACTTTTTATTTCAGGACAAAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TCTTCATAGAACTGTTGTTTATTAGTGATGATATGTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGAGCTATTTCTTTGTCGTCTTGTCTTGAGACTTG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAGAACATACTATTAATAATACATCAAGAACATC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AATCGGCGCAAAGGACTACGCCGCCGGCAACCACGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCGCTCCCTTTTTAACCCCGAGCGCGGGCATATT
GTTTTAATTCCTGTATGGTGCAATTGAAAT

>NC_015571|5|2|293622-294703|PILER-CR
TTTTAATTCCTGTATGGTGCAATTGAAATG	GGGATGAGCGGCGATGGCTTAATCGGGCGTCTGTTG
TTTTAATTCCTGTATGGTGCAATTGAAATT	TGCATACCGACCTCTTCCAACGAGCCTGCATCGCTCG
TTTTAATTCCTGTATGGTGCAATTGAAATT	TCCAGCCTGCAGACGACAAAGCAGGCGCCTCGAAGGG
TTTTAATTCCTGTATGGTGCAATTGAAATG	GCGTACCCCCTATGACAGCTACCCGGCTACTCATCG
TTTTAATTCCTGTATGGTGCAATTGAAATG	ATAACTGGTTCGAGGAGTACGAGCGTAATATGGATAG
TTTTAATTCCTGTATGGTGCAATTGAAATG	GGGGGCGGGCAGCACGGCGGTGATCTGCTTTTCGGG
TTTTAATTCCTGTATGGTGCAATTGAAATA	CGATCGCCGGCGAGGATCTTACCGGTTACACGGTAG
TTTTAATTCCTGTATGGTGCAATTGAAATC	GGAATGCTACTTACTATGCGCGCGCATCCTCGCG
TTTTAATTCCTGTATGGTGCAATTGAAATG	ACGTTTATCTTATAGTCGAATTGATTGCTCATTGTG
TTTTAATTCCTGTATGGTGCAATTGAAATG	AACAAGCTGGTCGTTCAGAATCATTATCACTTTG
TTTTAATTCCTGTATGGTGCAATTGAAATC	GGTAGCGAAAACTACTTTTTATTTCAGGACAAAGAG
TTTTAATTCCTGTATGGTGCAATTGAAATT	CTTCATAGAACTGTTGTTTATTAGTGATGATATGTTG
TTTTAATTCCTGTATGGTGCAATTGAAATT	GAGCTATTTCTTTGTCGTCTTGTCTTGAGACTTGG
TTTTAATTCCTGTATGGTGCAATTGAAATT	AGAACATACTATTAATAATACATCAAGAACATCG
TTTTAATTCCTGTATGGTGCAATTGAAATA	ATCGGCGCAAAGGACTACGCCGCCGGCAACCACGGCG
TTTTAATTCCTGTATGGTGCAATTGAAATT	TCGCTCCCTTTTTAACCCCGAGCGCGGGCATATTG
TTTTAATTCCTGTATGGTGCAATTGAAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_013815285.1|282818_284162_-|deoxyguanosinetriphosphate-triphosphohydrolase-family-protein	unknown	unknown	gnl|CDD|273571
NC_015571.1|WP_005874861.1|301916_302429_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_015571.1|WP_005874903.1|285807_286167_+|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815300.1|308004_308670_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_015571.1|WP_004583651.1|280628_282026_-|signal-peptidase-I	unknown	unknown	gnl|CDD|182787
NC_015571.1|WP_013815297.1|304741_305758_-|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1	cas7b	cd09717_cas7b_CAS-I-B	gnl|CDD|132528
NC_015571.1|WP_013815290.1|290354_292103_+|phospho-sugar-mutase	unknown	unknown	gnl|CDD|100092
NC_015571.1|WP_013815299.1|307264_308008_-|type-I-PGING-CRISPR-associated-protein-Cas5p	cas5	cd09716_cas5_CAS-I-B	gnl|CDD|132527
NC_015571.1|WP_013815288.1|286473_288975_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|238657
NC_015571.1|WP_010956473.1|300640_300904_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_015571.1|WP_013815293.1|294856_295942_-|IS5-family-transposase	unknown	unknown	gnl|CDD|377531
NC_015571.1|WP_005874941.1|284305_285298_-|putative-sulfate-exporter-family-transporter	unknown	unknown	gnl|CDD|225411
NC_015571.1|WP_013815284.1|282041_282758_-|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl|CDD|234595
NC_015571.1|WP_005874853.1|300903_301920_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|274695
NC_015571.1|WP_013815296.1|302448_304752_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|273707
NC_015571.1|WP_013815291.1|292361_293447_-|IS5-family-transposase	unknown	unknown	gnl|CDD|377531
NC_015571.1|WP_102947769.1|308692_308941_-|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_013815289.1|289544_290282_+|DNA-repair-protein-RecO	unknown	unknown	gnl|CDD|376822
NC_015571.1|WP_010956469.1|280012_280639_-|signal-peptidase-I	unknown	unknown	gnl|CDD|274044
NC_015571.1|WP_013815298.1|305768_307268_-|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2	cas8b4	cd09715_cas8b4_CAS-I-B	gnl|CDD|132526

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_015571.1|WP_005874853.1|300903_301920_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	8e-132	433.9	2.2
NC_015571.1|WP_013815298.1|305768_307268_-|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2	cas8b4	cd09715_cas8b4_CAS-I-B	2e-253	835.7	2.7
NC_015571.1|WP_005874861.1|301916_302429_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	2.4e-53	175.3	0.6
NC_015571.1|WP_013815300.1|308004_308670_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	5.8e-33	109.6	0.0
NC_015571.1|WP_013815296.1|302448_304752_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	1.6e-135	446.4	0.0
NC_015571.1|WP_013815299.1|307264_308008_-|type-I-PGING-CRISPR-associated-protein-Cas5p	cas5	cd09716_cas5_CAS-I-B	1.8e-136	447.6	0.6
NC_015571.1|WP_013815297.1|304741_305758_-|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1	cas7b	cd09717_cas7b_CAS-I-B	2.4e-192	632.3	4.6
NC_015571.1|WP_010956473.1|300640_300904_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	5.1e-29	95.1	0.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_013815285.1|282818_284162_-|deoxyguanosinetriphosphate-triphosphohydrolase-family-protein	gnl|CDD|273571	TIGR01353, dGTP_triPase, deoxyguanosinetriphosphate triphosphohydrolase, putative. dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions].	5.94057e-159
NC_015571.1|WP_005874861.1|301916_302429_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.76681e-68
NC_015571.1|WP_013815291.1|292361_293447_-|IS5-family-transposase	gnl|CDD|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.68725e-23
NC_015571.1|WP_013815300.1|308004_308670_-|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.51138e-36
NC_015571.1|WP_004583651.1|280628_282026_-|signal-peptidase-I	gnl|CDD|182787	PRK10861, PRK10861, signal peptidase I.	8.0144e-17
NC_015571.1|WP_013815297.1|304741_305758_-|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1	gnl|CDD|132528	TIGR03489, cas_csp1, CRISPR-associated protein Cas7/Csp1, subtype PGING. Members of this protein family are Csp1, a CRISPR-associated (cas) gene marker for the Pging subtype of CRISPR/cas system, as found in Porphyromonas gingivalis W83 and Bacteroides forsythus ATCC 43037. This protein belongs to the family of DevR (TIGR01875), a regulator of development in Myxococcus xanthus located in a cas gene region. A different branch of the DevR family, Cst2 (TIGR02585), is a marker for the Tneap subtype of CRISPR/cas system.	0
NC_015571.1|WP_013815290.1|290354_292103_+|phospho-sugar-mutase	gnl|CDD|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NC_015571.1|WP_013815299.1|307264_308008_-|type-I-PGING-CRISPR-associated-protein-Cas5p	gnl|CDD|132527	TIGR03488, cas_Cas5p, CRISPR-associated protein Cas5, subtype PGING. CC Members of this protein family are cas, or CRISPR-associated, proteins. The two sequences in the alignment seed are found within cas gene clusters that are adjacent to CRISPR DNA repeats in two members of the order Bacteroidales, Porphyromonas gingivalis W83 and Bacteroides forsythus ATCC 43037. This cas protein family is unique to the Pgingi (Porphyromonas gingivalis) subtype, but shows some sequence similarity to genes of the Cas5 type (see TIGR02593).	4.70758e-157
NC_015571.1|WP_013815288.1|286473_288975_+|TonB-dependent-receptor	gnl|CDD|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.15123e-42
NC_015571.1|WP_010956473.1|300640_300904_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.04042e-30
NC_015571.1|WP_013815293.1|294856_295942_-|IS5-family-transposase	gnl|CDD|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.70743e-22
NC_015571.1|WP_005874941.1|284305_285298_-|putative-sulfate-exporter-family-transporter	gnl|CDD|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	6.63986e-54
NC_015571.1|WP_013815284.1|282041_282758_-|4-hydroxy-tetrahydrodipicolinate-reductase	gnl|CDD|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	1.17269e-51
NC_015571.1|WP_005874853.1|300903_301920_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	8.51691e-165
NC_015571.1|WP_013815296.1|302448_304752_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	2.55385e-158
NC_015571.1|WP_013815298.1|305768_307268_-|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2	gnl|CDD|132526	TIGR03487, cas_csp2, CRISPR-associated protein Cas8c/Csp2, subtype PGING. Members of this protein family are cas, or CRISPR-associated, proteins. The two sequences in the alignment seed are found within cas gene clusters that are adjacent to CRISPR DNA repeats in two members of the order Bacteroidales, Porphyromonas gingivalis W83 and Bacteroides forsythus ATCC 43037. This cas protein family is unique to the Pging (Porphyromonas gingivalis) subtype.	0
NC_015571.1|WP_102947769.1|308692_308941_-|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	1.54497e-06
NC_015571.1|WP_013815289.1|289544_290282_+|DNA-repair-protein-RecO	gnl|CDD|376822	pfam02565, RecO_C, Recombination protein O C terminal. Recombination protein O (RecO) is involved in DNA repair and pfam00470 pathway recombination.	3.22277e-19
NC_015571.1|WP_010956469.1|280012_280639_-|signal-peptidase-I	gnl|CDD|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	3.40429e-12

Protein sequences

>NC_015571.1|WP_013815291.1|292361_293447_-|IS5-family-transposase
MAYQSKNTDEHVTFADALLSKRYRKAQNDFLNQVDTLNDWRPIRTLINKKYTKRQNAIGAPAYDVILLFKMLLLETWYNLSDCALEERINDSITFSRFLGLKMEEVSPDHSTISRFRSALTELGLMDKLLAQFNKQLSRHHISVREGVLVDASLVETPHKPNGSITIEVADDREDNRSEEEKEAEEDYQKQVVRRRKGTDEEARWVYKQKRYHYGYKKHCPANVQGIVQKVITTAANRSDTKEFIPLLEGANIPQGTAVLADKGYACGENRSYLQTHHLQDGIMHKAQRNRALTEEEKQGNKAISPIRSTIERTFGSIRRWFHGGRCRYRGLAKTHTQNILESIAFNLYRTPGIIMSSSLR
>NC_015571.1|WP_013815290.1|290354_292103_+|phospho-sugar-mutase
METDKLLDQVRAKARIWLGTEYDDSTRKAVQAMLDNADTTELVDAFYRDLEFGTGGLRGIMGAGTNRMNRYTVGAATQGLSNYLLRVFAGSSDISVVIGYDCRNNSRFFADTAAAVFSANGIGVYLFEELRPTPEISYAIRHLGCKSGVMITASHNPKEYNGYKAYWEDGAQIIAPHDRNIIAEVNRIRSVDEIKFEAKPELIRMIGENIDSAFIAEVKALSLSPESIARHRDMKIVYTPIHGTGSTVVPRALREYGFANIIHVPEQDVVSGDFPTVHSPNPEEPAALAMAIAKAEETSADLVLASDPDADRIGVAVRNNEGRMVLINGNEICSLLIYYSIMRRKELGDLHPDDYIVKTIVTTELIRDIAKKEHVSMFDCYTGFKWIAAVIRENEGRRRYIGGGEESYGFLWEDFIRDKSSVSACALFCEMAAWALDRGMSVYRLIRSIYLEYGLYYEKGLSVVRKGKSGAEEIEAMMRNYREYAPVELGGSPVQEILDYASLEGKDFTRGEKFSLDMPTTSNVLQYKTEDGTKVSIRPSGTEPKIKFYIGVHFSVANEQELDRAYIVAEEKIATILHDLGV
>NC_015571.1|WP_013815289.1|289544_290282_+|DNA-repair-protein-RecO
MIIVSRAIVLHNTAYNDSYSIAHLFSRESGRVSYLIPRSSKRGKSGGSLRLLISPLNELEITAEHKQHRDLHFIKEAKLCSLHGRIQSDPVRNSIALFLAEFLYLILRLPEADTNLYDFVAFSIDKLEEMDGPMANFHLAFLFRLLVPLGLIPDLQFGGSVIPHWFDPADGRFVPNAPAHGRGIPPHQSTYLQLFSRITFDNMKAFRLSRAERRQVLDYLVDYYRFHLPPFPLLKTPDILSTLFD
>NC_015571.1|WP_013815288.1|286473_288975_+|TonB-dependent-receptor
MKQLNIISFIIAFLFLGTSASAQQSGGSVTGTVVDKSSKEPIAYVQVFVKGTTLGTSTDANGNYSIKGIPSGNQTIVARLMGYSTCEEKVHIEKGGSRHVDLYLTEEILSLDGVVVSANRNETFRRQAPSLVTVLSPELFLKTNSTNLSQGLKFQPGLRVEDNCQNCGFNQVRINGLEGAYSQILIDSHPIFSSLAGVYGLEQMPANMIERVEVIRGGGSALFGSNAVGGVINVITKEPLRNSAEISHSTMTFDHAKGWGSFQNTTQFNGSMLTEDRKAGVMVFGQHNYRPGQDIDGDSFTELPNLRNRSLGFRSYYKTGLYSKATLEYHSMQEYRRGGDRLDNPPFEAQIAEYLQHYINGGSFKFDQGFSGGKDFFSLYASAQDVQRRSYYGGGDYTENLLNGAVQSGSTESDEYNNAFTALTSYGTTKGFDLQGGGMYRHTFGENWDFTGGLEYIYGQLDDRSGYRPSKIDQNTSTFSQYDQLEYKTEKLSALIGARIDYVLLNQDGKRYIDPLFIFSPRANVRYNPNKNLSFRLSYSEGFRAPQYFDEDLHVELAGGTPISRVLSPNLKEERSRSISASFDYYHRADEWQFNIMGEAFSTFISNQFKPSDKVETTSDGKEWIIRTIYNDKDGVSKVYGVNLEGRIAYNKSFDLQLGGTWQRSRYGSIYTAVEADKTTGQAEISVKDYVRTPNLYGYFVATVRPTEHFAINLSGTFTGKMDVVHEAYEGDIPAEHIAPDGSFDFEMNGQQFKGLAEGHAKLVKTPAFADIDLKLSHDFHLASTMTLELNAGIQNIFNSYQKDTDKGPGRASTYVYGPMQPRRIFVGTKINF
>NC_015571.1|WP_005874903.1|285807_286167_+|hypothetical-protein
MKERLNQTVRYFLPILFAVYAGLVISFTHVHIINGVIIVHSHVQWGDNESDPQDNPHSDSELILYNQLSAIFTTYLDTPAIDLKEPVRVVGVVPFFCDNLTALISELTPSNHLRAPPVA
>NC_015571.1|WP_005874941.1|284305_285298_-|putative-sulfate-exporter-family-transporter
MNTDNPKSHISRIAYPAIIVFLILTLLGSLVERFHPFTSWLTPPVALLMGLAYALIFGSTHRRANKLGSKVLLQYSVVGLGFGMNLGESLASGRDGMMFTIISVFGTLLLGWFIGRKILQMNRNTSALISAGTAICGGSAIAAVGPILKAEEHEMSVALGTVFLLNAVALFIFPSIGHWLALDQQQFGTWAAIAIHDTSSVVGAGSAYGEEALRVATTIKLTRALWIVPLTLVFSFVYKTKGAKRFPVPLFILFFIGAIILNTYLLEAYFPEVGRFVASLARKGLTLSLFFIGASLTKEVIASVGVRALLQGLFLWILISVGSLAFILLI
>NC_015571.1|WP_013815285.1|282818_284162_-|deoxyguanosinetriphosphate-triphosphohydrolase-family-protein
MTMMQWERLLSDKRVGMEHYHQPKQSAQPWERTDFERDYDRMVFSSPFRRLQNKAQVFPLAGNIFVHNRLTHSLEVSCVGRSLGNNITRGLKARYGELPWESGAISAIVSAACLAHDMGNPPFGHSGERAISAYFREGKGRVWEDAVRKEGGRWEDFLHFEGNANAFRLLTHQFEGRRKGGFALTYSTVASIVKYPYSSEMAGKAGKFGFFATEEDTFLMIAEELGMLCRNEHPVKYARYPLVYLVEAADDICYQIMDIEDAYKLRILTYAETENLFLAFCPEEELRHIRGVLDHITDANEQIAYLRSRVISLLVESCTRVFLDHEDEILSGTFSGTLIGAMEPRLKEAYGACARMAYSKIYVARDVVDVELAGHQIFGALIDKMMQALTNPDHAYSRTLLSRVSTQYNIREESLYGKIQCTLDYISGMTDIYALDLYRKITGMNLR
>NC_015571.1|WP_013815284.1|282041_282758_-|4-hydroxy-tetrahydrodipicolinate-reductase
MKIVLIGYGKMGHVIERIACSRGHEVVLTIDAGEEDRFDSIAFRSADVAIEFTRPDAAYANCSRCMDKSVPVVCGTTGWTERLPVLEERCRREGKTLFWASNFSIGVNLFFSLGRMFARLMSRHDQYRPHLTEIHHVHKLDAPSGTAITLAEGLIAESPSLDAWRLTETPEENELPITSIREGEVPGTHSISYTSEVDRLTICHEAFGREGFALGAVLAAEYAATHKGFLTMNDLISL
>NC_015571.1|WP_004583651.1|280628_282026_-|signal-peptidase-I
MTFHWKDLTPWRRIKGVAITILYLLFCIWAGPFWLIFLPLIVDYYFFHIIKWGWYKNIRNKTLRIICSWVADIIYCVVAVTFIFAFLFQNFAIPTSSLEKTLLIGDYLFVSKLSYGPRSPMTPLGVPLTHNTMPLTGGKSFSDKPLLPYKRLKGFGHVKEGDLVVFNFPAGDTVAVKQPNPDYYMWKKLVGREELWSNPDFYGEIVYRPVDRRDHYVKRCVGMPGQELSIRNNQIYIDGKEQRNPRNMQLNYLVRMSREMSVDLIDELGISYDDVRAASSEELKASVGSNLIDSASNQPQIIYHLPLTQGMLDKLQAEPSFVKAVEEPTPIGPLYPLEYETGWTRDNYGPIVIPAKGMTVRLTPLNLALYSRCIRNFEGNKLVQKADGTVLINGRTADSYTFKMDYYFMMGDNRHNSADSRYWGFVPEDHIVGKPVFIWLSLNKDKSLFGGKIRFGRMMRTVNAD
>NC_015571.1|WP_010956469.1|280012_280639_-|signal-peptidase-I
MQIKSRYRNRIFFIGLPAVVLLSAVLIRLFLVTTYRVRSDAMLPTYRSGKLLWINRIASPDRGDILVIKYRQDGEADSRFYLARLIGLPGDTLFLSKGGVVANRQKLKLPTSLLPREPYKIIVPRNDRTYRLTPLSLLAYRRAIEEECSSNISFRRGKLYRDGAETAFFHFRRNYYWILADNPASGPDSRHLGIVPEESIVGVVMNAN
>NC_015571.1|WP_013815293.1|294856_295942_-|IS5-family-transposase
MAYQSKNTDEHVTFADALLSKRYRKAQNDFLNQVERLIDWRPIRTLINKKYTKRQNAIGAPAYDVILLFKMLLPKTWYNLSDCALEERINDSITFSRFLGLKMEEVSPDHSTISRFRSALTELGLMDKLLAQFNKQLSRHHISVREGVLVDASLVETPHKPNGSITIEVADDRQDNRSEEEKEAEEDYQKQVVRQRKGTDEEARWVYKQKRYHYGYKKHCLTNVQGIVQKVITTAANRSDTKEFIPLLQGANIPQGTAVLADKGYACGENRSYLQTHHLQDGIMHKAQRNRALTEEEKQRNKAIGPIRSTIERTFGSIRRWFHGGRCRYRGLAKTHTQNILESIAFNLYRTPGIIMSSSVG
>NC_015571.1|WP_010956473.1|300640_300904_-|CRISPR-associated-endonuclease-Cas2
MYIILVYDIGEKRVGKMLKLCRKYLNWIQNSVFEGEISEVKLLELKSRAAGIMEKEEDSLIIFSSRQERWLEKEIIGKERSATDIFL
>NC_015571.1|WP_005874853.1|300903_301920_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTYYLFNPGELSRKDNTIRFVPIQEGENGQEQAGQARYIPVEGISDFYVFGSLRANSSLYNFLGSNDIAVHFFDYYENYTGSFMPRDFLLSGKMLLAQASAYKNKKKRLFLARKFIEGAASNMQKNLAYYNNRGKDMQPMMELIDKYSLRLKETTTIEALMGIEGNIRQAYYDAFNLIIDPFEMGVRSKQPPQNEVNALISFGNMMCYTLCLKAIHQSQLNPTISFLHTPGERRYSLCLDISEVFKPILVDRTIFKVMNKRIIQAKHFDKQLNKCILNPSGKKLFVQAFEERLSETIRHRKLNRSVSFRHLVKLECYKIAKDILGIEEYQPFKMYW
>NC_015571.1|WP_005874861.1|301916_302429_-|CRISPR-associated-protein-Cas4
MNTISGTHFNYHQVCRRKLWLFSAGITMEHTSDLVYEGKLIHETTYQQRPERYQELELDGIKIDFYDAKNRVVHEVKKSNKISPAHRLQLLYYLYVLERNGVLGATGILEYPTLRKKEEVILSDIDRERIREIEQEILQIISHEDCPPVIDSGICKNCSYYEFCFSGEEQ
>NC_015571.1|WP_013815296.1|302448_304752_-|CRISPR-associated-helicase/endonuclease-Cas3
MINKESPILAKPSGITLDVHAENVIQEGALLLKGLGCTKEKYFQTTAKQIVQRVELACKYHDIGKRNKIWQDACKKDYKAYLIWKKIHPNKSFEDYTIECREEAGKFLRQTHVRHEFYSIKGLLNNNPPPWLKIAIAAHHRKLSMKHEERWLSSDEDICSVWKDIRRLSNCFFDDRNSVLSDIVIKQYEFAGPRSLLQLADHRASAKEESKDIPDPIAFSYTFPEKWEKRPVQKLVEKHWRDELLLVRAPTGAGKTDAALLWASLQIKHRKADRLIIAMPTRFTTNALALNVSSTLSSTGLYHSSAWTQNFSSKIDNGEIALEQARYYHNQARLLQTPITVCTIDHLLSSLTLCDEEHQTITFALANACLVIDEADFYDQFTQANILVLLEVLKYWKVPILLMSASLPDNIVQEYRKIGYDIKHILEDTSDIERARFSLIEKRDVSEISQMQDLLQLCLDRGSAIIFANTVDRAQAYYQWFLENGHEEEVILYHSRYTETDKIEKEAQLLLRLGRSAWDNDRANGVAILTQIGEMSVNISADIMISDLCPIDRLTQRCGRLCRFSRKIGDLYIIRPMREGNLFPAPYYQNVGPSQKLEPNDALIKTDELLEKGMYSAANLVQLLNKVYANQTVFSTEASCNADRLREMFKANWLINPIEYLDEEIGSTNFWRARNIMPRCRIYIKRPLQSFRNYSDFRRWETDVAIDIPIYVIKKAMRMSDTVCSQVKVCIGKNDYTLIVINAKCYNNVRGLFFSKSVLEEPNFEFL
>NC_015571.1|WP_013815297.1|304741_305758_-|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1
METKKIAGVLVTMVAPFENHMANGGEKLFGNASSIKRRPDGRVYVSGQMQRHVLFSAIDRLNHLDKAKGTTFVSNGDGITNLIEIDLRADLGGFMHTNKGDYSDRRIAPLSVTPATALDTSSVGRDLLVRIRFDKSSDAKNQALATREYSEQDKMNMNFFLDITSVGVSKSFVYKDGLNLGTKYFKHITDDEKKRRVKLFLEATRIMNDYANQARNAVCGEPEKVLIVFDDRLSRKACRYYTAGEKEQANIIKELNECQVKYFIGDDTSDYSVADAYRDAINYLDKATFVDLAEGEEIMTFAEAFECKEKEPQGKKSKKGKDKATSAQNLFAEQQDDQ
>NC_015571.1|WP_013815298.1|305768_307268_-|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2
MNTNHYYIRYGCAITLYDNHVSERERLTPKELRFSIEKAVSSFRIQAQEPFSPGSKARFSFVKRKDGNTKNGIFLSPHIVTKDMHAQKVWTKASKFLEIDYLGKDNEREGLLKKDNVSMSNIPISGEFLTFGEKDTGRGSAKISVEEQTYGLITTLTTLKPALQVGKDNFCIIPDIPLNQMVDFITLLDKMQITHLSGEAMLGNIDNKGIPHRPKIFRGNFPNSPKSDRMGAIALLGAIGEFAKHAEFSTLAQKVLDSLKGSTLYLITYANAIPFTFHHYIIDLAKEGKLHSIVDSLFYSRLYKKEKRVYGDTDYDRFDFFANRFLQSFNKAAFDDFFSSRVEYPNQIKILFQMFFTKMEKLKTDVIASAQVLGSWLNQVAYFAAKEEADSRISPGNIFEEKAKFLVMMESSIYAAKRGDALIAQILILAGRLSKNEAPKEALLFMEKTITGEIDLSVAKNLLIAYMRIRREEKQRDLNSVKNDDAIPSDINIDDLTNT
>NC_015571.1|WP_013815299.1|307264_308008_-|type-I-PGING-CRISPR-associated-protein-Cas5p
MKYNMKNIDLSILGKDPDLSASIKLHIEPHAPISMVSELPGSYYKALLYPDKHILCGLFENVLGWHFSRKDREIITKEIKNIRKKAKKGYIPPTIRSIFIPLLSDFFELDSVRIVSTDSPFFYNDLWKRAFRRKDAGKIHFGGTQNIDYTLVMDKFRFMCENERALETEEKTDQKEEKFLRENIDRISFFYTTPTNREYLFFEGNYECVIKMDPQLVDLLSKTLPQQNMGYLGNSEGWVTLYLEEKS
>NC_015571.1|WP_013815300.1|308004_308670_-|CRISPR-associated-endoribonuclease-Cas6
MRIELSIKADDSLVSFSHQHLLVGTLQKWLGENDMHGKSISYSFSRLNGGKLVSELNSILFADWANMFVSAHDPELIRRMLAGIRQDPEMFKSLCVREVTVIEDPDMTDREIFFPASPILLKRWREDNGFDHIVYTDEAANALLTENLRKKLQAVGIDDPTATASFVPDKGKAKVMLIDYRGVKNKASWCPIRIIGNAETKLFAWNAGIGNSTGIGFGAIK
>NC_015571.1|WP_102947769.1|308692_308941_-|DUF1661-domain-containing-protein
MVREIKNSRATTKNFLFRFFRKHAPQSEHFRFVFYTPPSPLFYFQCGFRKIPRNDGCYISDFLANKHKKYALITAFRVTLGH

Crispr_ID: NC_015571_6

• CRISPR_ID: NC_015571_6
• CRISPR_location: 296084-300394
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 65 spacers
• Cas_protein_info: cas2,cas1,cas4,cas3,cas7b,cas8b4,cas5,cas6

Consensus repeat of NC_015571_6

Consensus_repeat	Method
GTTTTAATTCCTGTATGGTGCAATTGAAAT	PILER-CR
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CRISPRCasFinder
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CRT

spacers of NC_015571_6

>6.1|296114|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TGTCATATAGATATGACATCTTAGATATTGGTACTA
>6.2|296180|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TGTCATATAGATATGACATCTTAGATATTGGTACTA
>6.3|296246|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TGTCATATAGATATGACATCTTAGATATTGGTACTA
>6.4|296312|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TGTCATATAGATATGACATCTTAGATATTGGTACTA
>6.5|296378|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TGTCGTAACAGCAGGGATGAACTATGCGCTGCACG
>6.6|296443|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CGTTATACCTTCTATCGTCTTCAAATCTAAGGAT
>6.7|296507|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GGGTGGCGAGCAATGACGCGCTCCAGAACCCGACCG
>6.8|296573|37|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CCTTTGCCGTACGGGCGCGGCCGTAATGCGATCAAAG
>6.9|296640|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
AATACGTAGGAGGCGGACTATGATAGTAGCGATTAT
>6.10|296706|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CGTCAGCGCTTCAAGTACTCCACCCGCTCCTACGAG
>6.11|296772|37|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TTGTAGAATCTTATGTTTTTAGAGAACTATTTAATCA
>6.12|296839|38|NC_015571|PILER-CR,CRISPRCasFinder,CRT
ATGAAATAACCCCAAAGATAAATCCAACTACAGGCAAA
>6.13|296907|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TAAATAATCATTTAATTGTAACATTTTGTGAATA
>6.14|296971|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
ATAGTATCACACAACATCAAATGTTAGATGGATAT
>6.15|297036|38|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TTAGTAGGAGATGAAGACGACTTTTTTAACGTGGTCAA
>6.16|297104|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CTTTGTAGATTTATCGGATTATTTCGATATTATAA
>6.17|297169|37|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TTAATGCAAAAACTATAGTCCTCAACGCTAAAGACGC
>6.18|297236|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
AGTATGCCTGACACGCGAGATCGCACCTTGTCGAGG
>6.19|297302|38|NC_015571|PILER-CR,CRISPRCasFinder,CRT
ACGGGCGTTGTTCAGTCGGTCGTTATCGGAGTAATCGA
>6.20|297370|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
ACTATTCGGGAGGGAAGATATACAACGAGACCGAT
>6.21|297435|38|NC_015571|PILER-CR,CRISPRCasFinder,CRT
ACGGGGATGGCTCAGCCCTCGATTAGCCGGTTTCTGGC
>6.22|297503|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CTTGCCTTTAGAGCTCTTTTTTTATCAAGCTCATTG
>6.23|297569|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GCATTCGCGATTTTTCCGACCTCGAACGAATCGTAT
>6.24|297635|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GACGCAGGCGCGGGCGGACGTGTATAAAAAGTACT
>6.25|297700|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TTCGGTGGCATCGTCTTCGTTCGCATACAGAACGT
>6.26|297765|37|NC_015571|PILER-CR,CRISPRCasFinder,CRT
ATTTCTTACGCCCCATTCAAACTCATCCAGAAATTCT
>6.27|297832|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TGTTTCAGGATTTACCGTTGTGTACGTTCTGAGCT
>6.28|297897|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GTGAACGGAGCGTCGAAACAATGCCACGTTCCGAA
>6.29|297962|37|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CCGAGCGATAAGACCACATAAGGAGAAACGATCCGCT
>6.30|298029|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
ACCTGCAATAGATATACGACATAATTTCGTATTGCA
>6.31|298095|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CCTCTAAAATCATGTACGATTTTAGGGGGTTGTTTA
>6.32|298161|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
AGTAATTATTCAAATTTCTTGTTTATCGGATCTCT
>6.33|298226|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GAGGCCTCATTCGGCTCTATCTTCGCACCCGACAC
>6.34|298291|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TGTTGGCTTCCAACTTGTCGGCTTTGATCTCAACAT
>6.35|298357|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CCGACCTGCTTCCACCCTCTTCCGCCTTTATTCAA
>6.36|298422|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TCTTTTTTTGAAGAAAATTCATAGAAACAATGTAAG
>6.37|298488|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
>6.38|298554|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
>6.39|298620|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GTGATACGATTAATACGTTAGCGTTATTCTTCATG
>6.40|298685|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TTCTTTATCGTGATATTTTGTCCGCTCTTTTTGAC
>6.41|298750|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
AGGTTGCGCATTTCTTCTCCATGCAAGATGTAAACA
>6.42|298816|37|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TTCATGTCTATTCCTCTTCTTTATAGGTTCCTAATTT
>6.43|298883|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TAAATGCGTTCTCAATCACACCAATCTTGCCGGC
>6.44|298947|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CGTTCAGTTGTTCGCATTCAGTCGCCGACTGCCCC
>6.45|299012|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
ATCCACATTAGACGCATTCGCACTCGTCCAGCCCG
>6.46|299077|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CTGATGACATACAAAGAGTATATCGCGGCAATGGT
>6.47|299142|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TATCCTCGTACAGGTTTGCCACCTTGTCGGAGACGT
>6.48|299208|38|NC_015571|PILER-CR,CRISPRCasFinder,CRT
ATGCTTATTCAAAGGTGGATCGCGTGGTGATTTCTCAG
>6.49|299276|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CCTTCTACGATTACTGCCATTTACTTTACTTTTTTT
>6.50|299342|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TAATAGTCCACACCCCAACGCCAAAGGATGAATCG
>6.51|299407|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CGGTAATCCTCCAGCGACGCCAGCCCGTCCGTGGCG
>6.52|299473|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
AACGTCGATGTCTCAGGCGACTATGGCACAGCCACA
>6.53|299539|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CGACATGCCACCCGCAGGACACGATATGCCGCGAGA
>6.54|299605|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GCGGCCCTTGTCGGCCGCTCTCTCTTTCGTTATCGA
>6.55|299671|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GCGTACCCGCCTCTGCAGTTGCAAACACAGCTGCGA
>6.56|299737|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CCAGCCTTGTTTTTCGAACCCGAGGTGGCAAGGAC
>6.57|299802|37|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GTACAGGCGATTACGGGCGTGGTGGGTAAAGAGTTCG
>6.58|299869|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CCGCGTCGGACAAGTCCGCGGGCTGGAGACCCAGTA
>6.59|299935|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
TTTCTCTGACATTAAAATAGAAATCATCGCTGAAGA
>6.60|300001|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CCTCCGCCCCCAGCCCGCTATCGACCCCCACCTGC
>6.61|300066|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
AGGGCTGACGTGTATAAAAAATACCTGGGGGATAAT
>6.62|300132|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CTCAACCAGTTCGGGCTGGAGGCGTCGGAGGCGGCT
>6.63|300198|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
ACTTCGCCGTCCGCGGTAATGTGACCAATACCGAC
>6.64|300263|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CACCCACCCACGCCAGCACCCTCTGCCACCAGCGC
>6.65|300328|37|NC_015571|PILER-CR,CRISPRCasFinder,CRT
AACTCAAAAAAACTACAATAAATATGCCAACAGTAGT

CRISPR arrays and Neighbor proteins around NC_015571_6

CRISPR arrays

The CRISPR arrays of NC_015571_6

>merge|NC_015571|6|296084-300394|PILER-CR,CRISPRCasFinder,CRT
GTTTTAATTCCTGTATGGTGCAATTGAAATTGTCATATAGATATGACATCTTAGATATTGGTACTAGTTTTAATTCCTGTATGGTGCAATTGAAATTGTCATATAGATATGACATCTTAGATATTGGTACTAGTTTTAATTCCTGTATGGTGCAATTGAAATTGTCATATAGATATGACATCTTAGATATTGGTACTAGTTTTAATTCCTGTATGGTGCAATTGAAATTGTCATATAGATATGACATCTTAGATATTGGTACTAGTTTTAATTCCTGTATGGTGCAATTGAAATTGTCGTAACAGCAGGGATGAACTATGCGCTGCACGGTTTTAATTCCTGTATGGTGCAATTGAAATCGTTATACCTTCTATCGTCTTCAAATCTAAGGATGTTTTAATTCCTGTATGGTGCAATTGAAATGGGTGGCGAGCAATGACGCGCTCCAGAACCCGACCGGTTTTAATTCCTGTATGGTGCAATTGAAATCCTTTGCCGTACGGGCGCGGCCGTAATGCGATCAAAGGTTTTAATTCCTGTATGGTGCAATTGAAATAATACGTAGGAGGCGGACTATGATAGTAGCGATTATGTTTTAATTCCTGTATGGTGCAATTGAAATCGTCAGCGCTTCAAGTACTCCACCCGCTCCTACGAGGTTTTAATTCCTGTATGGTGCAATTGAAATTTGTAGAATCTTATGTTTTTAGAGAACTATTTAATCAGTTTTAATTCCTGTATGGTGCAATTGAAATATGAAATAACCCCAAAGATAAATCCAACTACAGGCAAAGTTTTAATTCCTGTATGGTGCAATTGAAATTAAATAATCATTTAATTGTAACATTTTGTGAATAGTTTTAATTCCTGTATGGTGCAATTGAAATATAGTATCACACAACATCAAATGTTAGATGGATATGTTTTAATTCCTGTATGGTGCAATTGAAATTTAGTAGGAGATGAAGACGACTTTTTTAACGTGGTCAAGTTTTAATTCCTGTATGGTGCAATTGAAATCTTTGTAGATTTATCGGATTATTTCGATATTATAAGTTTTAATTCCTGTATGGTGCAATTGAAATTTAATGCAAAAACTATAGTCCTCAACGCTAAAGACGCGTTTTAATTCCTGTATGGTGCAATTGAAATAGTATGCCTGACACGCGAGATCGCACCTTGTCGAGGGTTTTAATTCCTGTATGGTGCAATTGAAATACGGGCGTTGTTCAGTCGGTCGTTATCGGAGTAATCGAGTTTTAATTCCTGTATGGTGCAATTGAAATACTATTCGGGAGGGAAGATATACAACGAGACCGATGTTTTAATTCCTGTATGGTGCAATTGAAATACGGGGATGGCTCAGCCCTCGATTAGCCGGTTTCTGGCGTTTTAATTCCTGTATGGTGCAATTGAAATCTTGCCTTTAGAGCTCTTTTTTTATCAAGCTCATTGGTTTTAATTCCTGTATGGTGCAATTGAAATGCATTCGCGATTTTTCCGACCTCGAACGAATCGTATGTTTTAATTCCTGTATGGTGCAATTGAAATGACGCAGGCGCGGGCGGACGTGTATAAAAAGTACTGTTTTAATTCCTGTATGGTGCAATTGAAATTTCGGTGGCATCGTCTTCGTTCGCATACAGAACGTGTTTTAATTCCTGTATGGTGCAATTGAAATATTTCTTACGCCCCATTCAAACTCATCCAGAAATTCTGTTTTAATTCCTGTATGGTGCAATTGAAATTGTTTCAGGATTTACCGTTGTGTACGTTCTGAGCTGTTTTAATTCCTGTATGGTGCAATTGAAATGTGAACGGAGCGTCGAAACAATGCCACGTTCCGAAGTTTTAATTCCTGTATGGTGCAATTGAAATCCGAGCGATAAGACCACATAAGGAGAAACGATCCGCTGTTTTAATTCCTGTATGGTGCAATTGAAATACCTGCAATAGATATACGACATAATTTCGTATTGCAGTTTTAATTCCTGTATGGTGCAATTGAAATCCTCTAAAATCATGTACGATTTTAGGGGGTTGTTTAGTTTTAATTCCTGTATGGTGCAATTGAAATAGTAATTATTCAAATTTCTTGTTTATCGGATCTCTGTTTTAATTCCTGTATGGTGCAATTGAAATGAGGCCTCATTCGGCTCTATCTTCGCACCCGACACGTTTTAATTCCTGTATGGTGCAATTGAAATTGTTGGCTTCCAACTTGTCGGCTTTGATCTCAACATGTTTTAATTCCTGTATGGTGCAATTGAAATCCGACCTGCTTCCACCCTCTTCCGCCTTTATTCAAGTTTTAATTCCTGTATGGTGCAATTGAAATTCTTTTTTTGAAGAAAATTCATAGAAACAATGTAAGGTTTTAATTCCTGTATGGTGCAATTGAAATGCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCAGTTTTAATTCCTGTATGGTGCAATTGAAATGCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCAGTTTTAATTCCTGTATGGTGCAATTGAAATGTGATACGATTAATACGTTAGCGTTATTCTTCATGGTTTTAATTCCTGTATGGTGCAATTGAAATTTCTTTATCGTGATATTTTGTCCGCTCTTTTTGACGTTTTAATTCCTGTATGGTGCAATTGAAATAGGTTGCGCATTTCTTCTCCATGCAAGATGTAAACAGTTTTAATTCCTGTATGGTGCAATTGAAATTTCATGTCTATTCCTCTTCTTTATAGGTTCCTAATTTGTTTTAATTCCTGTATGGTGCAATTGAAATTAAATGCGTTCTCAATCACACCAATCTTGCCGGCGTTTTAATTCCTGTATGGTGCAATTGAAATCGTTCAGTTGTTCGCATTCAGTCGCCGACTGCCCCGTTTTAATTCCTGTATGGTGCAATTGAAATATCCACATTAGACGCATTCGCACTCGTCCAGCCCGGTTTTAATTCCTGTATGGTGCAATTGAAATCTGATGACATACAAAGAGTATATCGCGGCAATGGTGTTTTAATTCCTGTATGGTGCAATTGAAATTATCCTCGTACAGGTTTGCCACCTTGTCGGAGACGTGTTTTAATTCCTGTATGGTGCAATTGAAATATGCTTATTCAAAGGTGGATCGCGTGGTGATTTCTCAGGTTTTAATTCCTGTATGGTGCAATTGAAATCCTTCTACGATTACTGCCATTTACTTTACTTTTTTTGTTTTAATTCCTGTATGGTGCAATTGAAATTAATAGTCCACACCCCAACGCCAAAGGATGAATCGGTTTTAATTCCTGTATGGTGCAATTGAAATCGGTAATCCTCCAGCGACGCCAGCCCGTCCGTGGCGGTTTTAATTCCTGTATGGTGCAATTGAAATAACGTCGATGTCTCAGGCGACTATGGCACAGCCACAGTTTTAATTCCTGTATGGTGCAATTGAAATCGACATGCCACCCGCAGGACACGATATGCCGCGAGAGTTTTAATTCCTGTATGGTGCAATTGAAATGCGGCCCTTGTCGGCCGCTCTCTCTTTCGTTATCGAGTTTTAATTCCTGTATGGTGCAATTGAAATGCGTACCCGCCTCTGCAGTTGCAAACACAGCTGCGAGTTTTAATTCCTGTATGGTGCAATTGAAATCCAGCCTTGTTTTTCGAACCCGAGGTGGCAAGGACGTTTTAATTCCTGTATGGTGCAATTGAAATGTACAGGCGATTACGGGCGTGGTGGGTAAAGAGTTCGGTTTTAATTCCTGTATGGTGCAATTGAAATCCGCGTCGGACAAGTCCGCGGGCTGGAGACCCAGTAGTTTTAATTCCTGTATGGTGCAATTGAAATTTTCTCTGACATTAAAATAGAAATCATCGCTGAAGAGTTTTAATTCCTGTATGGTGCAATTGAAATCCTCCGCCCCCAGCCCGCTATCGACCCCCACCTGCGTTTTAATTCCTGTATGGTGCAATTGAAATAGGGCTGACGTGTATAAAAAATACCTGGGGGATAATGTTTTAATTCCTGTATGGTGCAATTGAAATCTCAACCAGTTCGGGCTGGAGGCGTCGGAGGCGGCTGTTTTAATTCCTGTATGGTGCAATTGAAATACTTCGCCGTCCGCGGTAATGTGACCAATACCGACGTTTTAATTCCTGTATGGTGCAATTGAAATCACCCACCCACGCCAGCACCCTCTGCCACCAGCGCGTTTTAATTCCTGTATGGTGCAATTGAAATAACTCAAAAAAACTACAATAAATATGCCAACAGTAGTGTTTTAATTCCTGTATGGTGCAATTGAAAT

>NC_015571|6|3|296084-300394|PILER-CR
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCGTAACAGCAGGGATGAACTATGCGCTGCACG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTATACCTTCTATCGTCTTCAAATCTAAGGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GGGTGGCGAGCAATGACGCGCTCCAGAACCCGACCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTTGCCGTACGGGCGCGGCCGTAATGCGATCAAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AATACGTAGGAGGCGGACTATGATAGTAGCGATTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTCAGCGCTTCAAGTACTCCACCCGCTCCTACGAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTGTAGAATCTTATGTTTTTAGAGAACTATTTAATCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGAAATAACCCCAAAGATAAATCCAACTACAGGCAAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATAATCATTTAATTGTAACATTTTGTGAATA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATAGTATCACACAACATCAAATGTTAGATGGATAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAGTAGGAGATGAAGACGACTTTTTTAACGTGGTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTTGTAGATTTATCGGATTATTTCGATATTATAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAATGCAAAAACTATAGTCCTCAACGCTAAAGACGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTATGCCTGACACGCGAGATCGCACCTTGTCGAGG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGCGTTGTTCAGTCGGTCGTTATCGGAGTAATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTATTCGGGAGGGAAGATATACAACGAGACCGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGGATGGCTCAGCCCTCGATTAGCCGGTTTCTGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTGCCTTTAGAGCTCTTTTTTTATCAAGCTCATTG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCATTCGCGATTTTTCCGACCTCGAACGAATCGTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GACGCAGGCGCGGGCGGACGTGTATAAAAAGTACT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCGGTGGCATCGTCTTCGTTCGCATACAGAACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATTTCTTACGCCCCATTCAAACTCATCCAGAAATTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTTCAGGATTTACCGTTGTGTACGTTCTGAGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGAACGGAGCGTCGAAACAATGCCACGTTCCGAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGAGCGATAAGACCACATAAGGAGAAACGATCCGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACCTGCAATAGATATACGACATAATTTCGTATTGCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCTAAAATCATGTACGATTTTAGGGGGTTGTTTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTAATTATTCAAATTTCTTGTTTATCGGATCTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GAGGCCTCATTCGGCTCTATCTTCGCACCCGACAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTGGCTTCCAACTTGTCGGCTTTGATCTCAACAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGACCTGCTTCCACCCTCTTCCGCCTTTATTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TCTTTTTTTGAAGAAAATTCATAGAAACAATGTAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGATACGATTAATACGTTAGCGTTATTCTTCATG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCTTTATCGTGATATTTTGTCCGCTCTTTTTGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGTTGCGCATTTCTTCTCCATGCAAGATGTAAACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCATGTCTATTCCTCTTCTTTATAGGTTCCTAATTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATGCGTTCTCAATCACACCAATCTTGCCGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTCAGTTGTTCGCATTCAGTCGCCGACTGCCCC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATCCACATTAGACGCATTCGCACTCGTCCAGCCCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTGATGACATACAAAGAGTATATCGCGGCAATGGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TATCCTCGTACAGGTTTGCCACCTTGTCGGAGACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGCTTATTCAAAGGTGGATCGCGTGGTGATTTCTCAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTCTACGATTACTGCCATTTACTTTACTTTTTTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAATAGTCCACACCCCAACGCCAAAGGATGAATCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGGTAATCCTCCAGCGACGCCAGCCCGTCCGTGGCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACGTCGATGTCTCAGGCGACTATGGCACAGCCACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGACATGCCACCCGCAGGACACGATATGCCGCGAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGGCCCTTGTCGGCCGCTCTCTCTTTCGTTATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGTACCCGCCTCTGCAGTTGCAAACACAGCTGCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCAGCCTTGTTTTTCGAACCCGAGGTGGCAAGGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTACAGGCGATTACGGGCGTGGTGGGTAAAGAGTTCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGCGTCGGACAAGTCCGCGGGCTGGAGACCCAGTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTTCTCTGACATTAAAATAGAAATCATCGCTGAAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCCGCCCCCAGCCCGCTATCGACCCCCACCTGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGGCTGACGTGTATAAAAAATACCTGGGGGATAAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTCAACCAGTTCGGGCTGGAGGCGTCGGAGGCGGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTTCGCCGTCCGCGGTAATGTGACCAATACCGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CACCCACCCACGCCAGCACCCTCTGCCACCAGCGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACTCAAAAAAACTACAATAAATATGCCAACAGTAGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT

>NC_015571|6|6|296084-300394|CRISPRCasFinder
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCGTAACAGCAGGGATGAACTATGCGCTGCACG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTATACCTTCTATCGTCTTCAAATCTAAGGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GGGTGGCGAGCAATGACGCGCTCCAGAACCCGACCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTTGCCGTACGGGCGCGGCCGTAATGCGATCAAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AATACGTAGGAGGCGGACTATGATAGTAGCGATTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTCAGCGCTTCAAGTACTCCACCCGCTCCTACGAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTGTAGAATCTTATGTTTTTAGAGAACTATTTAATCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGAAATAACCCCAAAGATAAATCCAACTACAGGCAAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATAATCATTTAATTGTAACATTTTGTGAATA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATAGTATCACACAACATCAAATGTTAGATGGATAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAGTAGGAGATGAAGACGACTTTTTTAACGTGGTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTTGTAGATTTATCGGATTATTTCGATATTATAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAATGCAAAAACTATAGTCCTCAACGCTAAAGACGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTATGCCTGACACGCGAGATCGCACCTTGTCGAGG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGCGTTGTTCAGTCGGTCGTTATCGGAGTAATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTATTCGGGAGGGAAGATATACAACGAGACCGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGGATGGCTCAGCCCTCGATTAGCCGGTTTCTGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTGCCTTTAGAGCTCTTTTTTTATCAAGCTCATTG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCATTCGCGATTTTTCCGACCTCGAACGAATCGTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GACGCAGGCGCGGGCGGACGTGTATAAAAAGTACT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCGGTGGCATCGTCTTCGTTCGCATACAGAACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATTTCTTACGCCCCATTCAAACTCATCCAGAAATTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTTCAGGATTTACCGTTGTGTACGTTCTGAGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGAACGGAGCGTCGAAACAATGCCACGTTCCGAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGAGCGATAAGACCACATAAGGAGAAACGATCCGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACCTGCAATAGATATACGACATAATTTCGTATTGCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCTAAAATCATGTACGATTTTAGGGGGTTGTTTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTAATTATTCAAATTTCTTGTTTATCGGATCTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GAGGCCTCATTCGGCTCTATCTTCGCACCCGACAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTGGCTTCCAACTTGTCGGCTTTGATCTCAACAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGACCTGCTTCCACCCTCTTCCGCCTTTATTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TCTTTTTTTGAAGAAAATTCATAGAAACAATGTAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGATACGATTAATACGTTAGCGTTATTCTTCATG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCTTTATCGTGATATTTTGTCCGCTCTTTTTGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGTTGCGCATTTCTTCTCCATGCAAGATGTAAACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCATGTCTATTCCTCTTCTTTATAGGTTCCTAATTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATGCGTTCTCAATCACACCAATCTTGCCGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTCAGTTGTTCGCATTCAGTCGCCGACTGCCCC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATCCACATTAGACGCATTCGCACTCGTCCAGCCCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTGATGACATACAAAGAGTATATCGCGGCAATGGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TATCCTCGTACAGGTTTGCCACCTTGTCGGAGACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGCTTATTCAAAGGTGGATCGCGTGGTGATTTCTCAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTCTACGATTACTGCCATTTACTTTACTTTTTTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAATAGTCCACACCCCAACGCCAAAGGATGAATCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGGTAATCCTCCAGCGACGCCAGCCCGTCCGTGGCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACGTCGATGTCTCAGGCGACTATGGCACAGCCACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGACATGCCACCCGCAGGACACGATATGCCGCGAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGGCCCTTGTCGGCCGCTCTCTCTTTCGTTATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGTACCCGCCTCTGCAGTTGCAAACACAGCTGCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCAGCCTTGTTTTTCGAACCCGAGGTGGCAAGGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTACAGGCGATTACGGGCGTGGTGGGTAAAGAGTTCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGCGTCGGACAAGTCCGCGGGCTGGAGACCCAGTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTTCTCTGACATTAAAATAGAAATCATCGCTGAAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCCGCCCCCAGCCCGCTATCGACCCCCACCTGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGGCTGACGTGTATAAAAAATACCTGGGGGATAAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTCAACCAGTTCGGGCTGGAGGCGTCGGAGGCGGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTTCGCCGTCCGCGGTAATGTGACCAATACCGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CACCCACCCACGCCAGCACCCTCTGCCACCAGCGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACTCAAAAAAACTACAATAAATATGCCAACAGTAGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT

>NC_015571|6|3|296084-300394|CRT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCATATAGATATGACATCTTAGATATTGGTACTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTCGTAACAGCAGGGATGAACTATGCGCTGCACG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTATACCTTCTATCGTCTTCAAATCTAAGGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GGGTGGCGAGCAATGACGCGCTCCAGAACCCGACCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTTGCCGTACGGGCGCGGCCGTAATGCGATCAAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AATACGTAGGAGGCGGACTATGATAGTAGCGATTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTCAGCGCTTCAAGTACTCCACCCGCTCCTACGAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTGTAGAATCTTATGTTTTTAGAGAACTATTTAATCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGAAATAACCCCAAAGATAAATCCAACTACAGGCAAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATAATCATTTAATTGTAACATTTTGTGAATA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATAGTATCACACAACATCAAATGTTAGATGGATAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAGTAGGAGATGAAGACGACTTTTTTAACGTGGTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTTGTAGATTTATCGGATTATTTCGATATTATAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTAATGCAAAAACTATAGTCCTCAACGCTAAAGACGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTATGCCTGACACGCGAGATCGCACCTTGTCGAGG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGCGTTGTTCAGTCGGTCGTTATCGGAGTAATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTATTCGGGAGGGAAGATATACAACGAGACCGAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACGGGGATGGCTCAGCCCTCGATTAGCCGGTTTCTGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTTGCCTTTAGAGCTCTTTTTTTATCAAGCTCATTG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCATTCGCGATTTTTCCGACCTCGAACGAATCGTAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GACGCAGGCGCGGGCGGACGTGTATAAAAAGTACT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCGGTGGCATCGTCTTCGTTCGCATACAGAACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATTTCTTACGCCCCATTCAAACTCATCCAGAAATTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTTCAGGATTTACCGTTGTGTACGTTCTGAGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGAACGGAGCGTCGAAACAATGCCACGTTCCGAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGAGCGATAAGACCACATAAGGAGAAACGATCCGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACCTGCAATAGATATACGACATAATTTCGTATTGCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCTAAAATCATGTACGATTTTAGGGGGTTGTTTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGTAATTATTCAAATTTCTTGTTTATCGGATCTCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GAGGCCTCATTCGGCTCTATCTTCGCACCCGACAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TGTTGGCTTCCAACTTGTCGGCTTTGATCTCAACAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGACCTGCTTCCACCCTCTTCCGCCTTTATTCAA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TCTTTTTTTGAAGAAAATTCATAGAAACAATGTAAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCTTTTTCACCTTTCGCGCCAATCGCTCAAAGCTCA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTGATACGATTAATACGTTAGCGTTATTCTTCATG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCTTTATCGTGATATTTTGTCCGCTCTTTTTGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGTTGCGCATTTCTTCTCCATGCAAGATGTAAACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTCATGTCTATTCCTCTTCTTTATAGGTTCCTAATTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAAATGCGTTCTCAATCACACCAATCTTGCCGGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGTTCAGTTGTTCGCATTCAGTCGCCGACTGCCCC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATCCACATTAGACGCATTCGCACTCGTCCAGCCCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTGATGACATACAAAGAGTATATCGCGGCAATGGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TATCCTCGTACAGGTTTGCCACCTTGTCGGAGACGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ATGCTTATTCAAAGGTGGATCGCGTGGTGATTTCTCAG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTTCTACGATTACTGCCATTTACTTTACTTTTTTT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TAATAGTCCACACCCCAACGCCAAAGGATGAATCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGGTAATCCTCCAGCGACGCCAGCCCGTCCGTGGCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACGTCGATGTCTCAGGCGACTATGGCACAGCCACA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CGACATGCCACCCGCAGGACACGATATGCCGCGAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGGCCCTTGTCGGCCGCTCTCTCTTTCGTTATCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GCGTACCCGCCTCTGCAGTTGCAAACACAGCTGCGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCAGCCTTGTTTTTCGAACCCGAGGTGGCAAGGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	GTACAGGCGATTACGGGCGTGGTGGGTAAAGAGTTCG
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCGCGTCGGACAAGTCCGCGGGCTGGAGACCCAGTA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	TTTCTCTGACATTAAAATAGAAATCATCGCTGAAGA
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CCTCCGCCCCCAGCCCGCTATCGACCCCCACCTGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AGGGCTGACGTGTATAAAAAATACCTGGGGGATAAT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CTCAACCAGTTCGGGCTGGAGGCGTCGGAGGCGGCT
GTTTTAATTCCTGTATGGTGCAATTGAAAT	ACTTCGCCGTCCGCGGTAATGTGACCAATACCGAC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	CACCCACCCACGCCAGCACCCTCTGCCACCAGCGC
GTTTTAATTCCTGTATGGTGCAATTGAAAT	AACTCAAAAAAACTACAATAAATATGCCAACAGTAGT
GTTTTAATTCCTGTATGGTGCAATTGAAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_013815285.1|282818_284162_-|deoxyguanosinetriphosphate-triphosphohydrolase-family-protein	unknown	unknown	gnl|CDD|273571
NC_015571.1|WP_005874861.1|301916_302429_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_015571.1|WP_013815291.1|292361_293447_-|IS5-family-transposase	unknown	unknown	gnl|CDD|377531
NC_015571.1|WP_013815300.1|308004_308670_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_015571.1|WP_004583651.1|280628_282026_-|signal-peptidase-I	unknown	unknown	gnl|CDD|182787
NC_015571.1|WP_013815290.1|290354_292103_+|phospho-sugar-mutase	unknown	unknown	gnl|CDD|100092
NC_015571.1|WP_013815299.1|307264_308008_-|type-I-PGING-CRISPR-associated-protein-Cas5p	cas5	cd09716_cas5_CAS-I-B	gnl|CDD|132527
NC_015571.1|WP_173362815.1|308909_309002_+|DUF1661-domain-containing-protein	unknown	unknown	unknown
NC_015571.1|WP_013815288.1|286473_288975_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|238657
NC_015571.1|WP_010956473.1|300640_300904_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_015571.1|WP_013815293.1|294856_295942_-|IS5-family-transposase	unknown	unknown	gnl|CDD|377531
NC_015571.1|WP_005874941.1|284305_285298_-|putative-sulfate-exporter-family-transporter	unknown	unknown	gnl|CDD|225411
NC_015571.1|WP_013815284.1|282041_282758_-|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl|CDD|234595
NC_015571.1|WP_005874853.1|300903_301920_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|274695
NC_015571.1|WP_013815296.1|302448_304752_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|273707
NC_015571.1|WP_005874903.1|285807_286167_+|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_102947769.1|308692_308941_-|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_013815289.1|289544_290282_+|DNA-repair-protein-RecO	unknown	unknown	gnl|CDD|376822
NC_015571.1|WP_013815297.1|304741_305758_-|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1	cas7b	cd09717_cas7b_CAS-I-B	gnl|CDD|132528
NC_015571.1|WP_013815298.1|305768_307268_-|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2	cas8b4	cd09715_cas8b4_CAS-I-B	gnl|CDD|132526

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_015571.1|WP_005874853.1|300903_301920_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	8e-132	433.9	2.2
NC_015571.1|WP_013815298.1|305768_307268_-|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2	cas8b4	cd09715_cas8b4_CAS-I-B	2e-253	835.7	2.7
NC_015571.1|WP_005874861.1|301916_302429_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	2.4e-53	175.3	0.6
NC_015571.1|WP_013815300.1|308004_308670_-|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	5.8e-33	109.6	0.0
NC_015571.1|WP_013815296.1|302448_304752_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	1.6e-135	446.4	0.0
NC_015571.1|WP_013815299.1|307264_308008_-|type-I-PGING-CRISPR-associated-protein-Cas5p	cas5	cd09716_cas5_CAS-I-B	1.8e-136	447.6	0.6
NC_015571.1|WP_013815297.1|304741_305758_-|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1	cas7b	cd09717_cas7b_CAS-I-B	2.4e-192	632.3	4.6
NC_015571.1|WP_010956473.1|300640_300904_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	5.1e-29	95.1	0.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_013815285.1|282818_284162_-|deoxyguanosinetriphosphate-triphosphohydrolase-family-protein	gnl|CDD|273571	TIGR01353, dGTP_triPase, deoxyguanosinetriphosphate triphosphohydrolase, putative. dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions].	5.94057e-159
NC_015571.1|WP_005874861.1|301916_302429_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.76681e-68
NC_015571.1|WP_013815291.1|292361_293447_-|IS5-family-transposase	gnl|CDD|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.68725e-23
NC_015571.1|WP_013815300.1|308004_308670_-|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.51138e-36
NC_015571.1|WP_004583651.1|280628_282026_-|signal-peptidase-I	gnl|CDD|182787	PRK10861, PRK10861, signal peptidase I.	8.0144e-17
NC_015571.1|WP_013815290.1|290354_292103_+|phospho-sugar-mutase	gnl|CDD|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NC_015571.1|WP_013815299.1|307264_308008_-|type-I-PGING-CRISPR-associated-protein-Cas5p	gnl|CDD|132527	TIGR03488, cas_Cas5p, CRISPR-associated protein Cas5, subtype PGING. CC Members of this protein family are cas, or CRISPR-associated, proteins. The two sequences in the alignment seed are found within cas gene clusters that are adjacent to CRISPR DNA repeats in two members of the order Bacteroidales, Porphyromonas gingivalis W83 and Bacteroides forsythus ATCC 43037. This cas protein family is unique to the Pgingi (Porphyromonas gingivalis) subtype, but shows some sequence similarity to genes of the Cas5 type (see TIGR02593).	4.70758e-157
NC_015571.1|WP_013815288.1|286473_288975_+|TonB-dependent-receptor	gnl|CDD|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.15123e-42
NC_015571.1|WP_010956473.1|300640_300904_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.04042e-30
NC_015571.1|WP_013815293.1|294856_295942_-|IS5-family-transposase	gnl|CDD|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.70743e-22
NC_015571.1|WP_005874941.1|284305_285298_-|putative-sulfate-exporter-family-transporter	gnl|CDD|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	6.63986e-54
NC_015571.1|WP_013815284.1|282041_282758_-|4-hydroxy-tetrahydrodipicolinate-reductase	gnl|CDD|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	1.17269e-51
NC_015571.1|WP_005874853.1|300903_301920_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	8.51691e-165
NC_015571.1|WP_013815296.1|302448_304752_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	2.55385e-158
NC_015571.1|WP_013815298.1|305768_307268_-|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2	gnl|CDD|132526	TIGR03487, cas_csp2, CRISPR-associated protein Cas8c/Csp2, subtype PGING. Members of this protein family are cas, or CRISPR-associated, proteins. The two sequences in the alignment seed are found within cas gene clusters that are adjacent to CRISPR DNA repeats in two members of the order Bacteroidales, Porphyromonas gingivalis W83 and Bacteroides forsythus ATCC 43037. This cas protein family is unique to the Pging (Porphyromonas gingivalis) subtype.	0
NC_015571.1|WP_102947769.1|308692_308941_-|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	1.54497e-06
NC_015571.1|WP_013815289.1|289544_290282_+|DNA-repair-protein-RecO	gnl|CDD|376822	pfam02565, RecO_C, Recombination protein O C terminal. Recombination protein O (RecO) is involved in DNA repair and pfam00470 pathway recombination.	3.22277e-19
NC_015571.1|WP_013815297.1|304741_305758_-|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1	gnl|CDD|132528	TIGR03489, cas_csp1, CRISPR-associated protein Cas7/Csp1, subtype PGING. Members of this protein family are Csp1, a CRISPR-associated (cas) gene marker for the Pging subtype of CRISPR/cas system, as found in Porphyromonas gingivalis W83 and Bacteroides forsythus ATCC 43037. This protein belongs to the family of DevR (TIGR01875), a regulator of development in Myxococcus xanthus located in a cas gene region. A different branch of the DevR family, Cst2 (TIGR02585), is a marker for the Tneap subtype of CRISPR/cas system.	0

Protein sequences

>NC_015571.1|WP_013815293.1|294856_295942_-|IS5-family-transposase
MAYQSKNTDEHVTFADALLSKRYRKAQNDFLNQVERLIDWRPIRTLINKKYTKRQNAIGAPAYDVILLFKMLLPKTWYNLSDCALEERINDSITFSRFLGLKMEEVSPDHSTISRFRSALTELGLMDKLLAQFNKQLSRHHISVREGVLVDASLVETPHKPNGSITIEVADDRQDNRSEEEKEAEEDYQKQVVRQRKGTDEEARWVYKQKRYHYGYKKHCLTNVQGIVQKVITTAANRSDTKEFIPLLQGANIPQGTAVLADKGYACGENRSYLQTHHLQDGIMHKAQRNRALTEEEKQRNKAIGPIRSTIERTFGSIRRWFHGGRCRYRGLAKTHTQNILESIAFNLYRTPGIIMSSSVG
>NC_015571.1|WP_013815291.1|292361_293447_-|IS5-family-transposase
MAYQSKNTDEHVTFADALLSKRYRKAQNDFLNQVDTLNDWRPIRTLINKKYTKRQNAIGAPAYDVILLFKMLLLETWYNLSDCALEERINDSITFSRFLGLKMEEVSPDHSTISRFRSALTELGLMDKLLAQFNKQLSRHHISVREGVLVDASLVETPHKPNGSITIEVADDREDNRSEEEKEAEEDYQKQVVRRRKGTDEEARWVYKQKRYHYGYKKHCPANVQGIVQKVITTAANRSDTKEFIPLLEGANIPQGTAVLADKGYACGENRSYLQTHHLQDGIMHKAQRNRALTEEEKQGNKAISPIRSTIERTFGSIRRWFHGGRCRYRGLAKTHTQNILESIAFNLYRTPGIIMSSSLR
>NC_015571.1|WP_013815290.1|290354_292103_+|phospho-sugar-mutase
METDKLLDQVRAKARIWLGTEYDDSTRKAVQAMLDNADTTELVDAFYRDLEFGTGGLRGIMGAGTNRMNRYTVGAATQGLSNYLLRVFAGSSDISVVIGYDCRNNSRFFADTAAAVFSANGIGVYLFEELRPTPEISYAIRHLGCKSGVMITASHNPKEYNGYKAYWEDGAQIIAPHDRNIIAEVNRIRSVDEIKFEAKPELIRMIGENIDSAFIAEVKALSLSPESIARHRDMKIVYTPIHGTGSTVVPRALREYGFANIIHVPEQDVVSGDFPTVHSPNPEEPAALAMAIAKAEETSADLVLASDPDADRIGVAVRNNEGRMVLINGNEICSLLIYYSIMRRKELGDLHPDDYIVKTIVTTELIRDIAKKEHVSMFDCYTGFKWIAAVIRENEGRRRYIGGGEESYGFLWEDFIRDKSSVSACALFCEMAAWALDRGMSVYRLIRSIYLEYGLYYEKGLSVVRKGKSGAEEIEAMMRNYREYAPVELGGSPVQEILDYASLEGKDFTRGEKFSLDMPTTSNVLQYKTEDGTKVSIRPSGTEPKIKFYIGVHFSVANEQELDRAYIVAEEKIATILHDLGV
>NC_015571.1|WP_013815289.1|289544_290282_+|DNA-repair-protein-RecO
MIIVSRAIVLHNTAYNDSYSIAHLFSRESGRVSYLIPRSSKRGKSGGSLRLLISPLNELEITAEHKQHRDLHFIKEAKLCSLHGRIQSDPVRNSIALFLAEFLYLILRLPEADTNLYDFVAFSIDKLEEMDGPMANFHLAFLFRLLVPLGLIPDLQFGGSVIPHWFDPADGRFVPNAPAHGRGIPPHQSTYLQLFSRITFDNMKAFRLSRAERRQVLDYLVDYYRFHLPPFPLLKTPDILSTLFD
>NC_015571.1|WP_013815288.1|286473_288975_+|TonB-dependent-receptor
MKQLNIISFIIAFLFLGTSASAQQSGGSVTGTVVDKSSKEPIAYVQVFVKGTTLGTSTDANGNYSIKGIPSGNQTIVARLMGYSTCEEKVHIEKGGSRHVDLYLTEEILSLDGVVVSANRNETFRRQAPSLVTVLSPELFLKTNSTNLSQGLKFQPGLRVEDNCQNCGFNQVRINGLEGAYSQILIDSHPIFSSLAGVYGLEQMPANMIERVEVIRGGGSALFGSNAVGGVINVITKEPLRNSAEISHSTMTFDHAKGWGSFQNTTQFNGSMLTEDRKAGVMVFGQHNYRPGQDIDGDSFTELPNLRNRSLGFRSYYKTGLYSKATLEYHSMQEYRRGGDRLDNPPFEAQIAEYLQHYINGGSFKFDQGFSGGKDFFSLYASAQDVQRRSYYGGGDYTENLLNGAVQSGSTESDEYNNAFTALTSYGTTKGFDLQGGGMYRHTFGENWDFTGGLEYIYGQLDDRSGYRPSKIDQNTSTFSQYDQLEYKTEKLSALIGARIDYVLLNQDGKRYIDPLFIFSPRANVRYNPNKNLSFRLSYSEGFRAPQYFDEDLHVELAGGTPISRVLSPNLKEERSRSISASFDYYHRADEWQFNIMGEAFSTFISNQFKPSDKVETTSDGKEWIIRTIYNDKDGVSKVYGVNLEGRIAYNKSFDLQLGGTWQRSRYGSIYTAVEADKTTGQAEISVKDYVRTPNLYGYFVATVRPTEHFAINLSGTFTGKMDVVHEAYEGDIPAEHIAPDGSFDFEMNGQQFKGLAEGHAKLVKTPAFADIDLKLSHDFHLASTMTLELNAGIQNIFNSYQKDTDKGPGRASTYVYGPMQPRRIFVGTKINF
>NC_015571.1|WP_005874903.1|285807_286167_+|hypothetical-protein
MKERLNQTVRYFLPILFAVYAGLVISFTHVHIINGVIIVHSHVQWGDNESDPQDNPHSDSELILYNQLSAIFTTYLDTPAIDLKEPVRVVGVVPFFCDNLTALISELTPSNHLRAPPVA
>NC_015571.1|WP_005874941.1|284305_285298_-|putative-sulfate-exporter-family-transporter
MNTDNPKSHISRIAYPAIIVFLILTLLGSLVERFHPFTSWLTPPVALLMGLAYALIFGSTHRRANKLGSKVLLQYSVVGLGFGMNLGESLASGRDGMMFTIISVFGTLLLGWFIGRKILQMNRNTSALISAGTAICGGSAIAAVGPILKAEEHEMSVALGTVFLLNAVALFIFPSIGHWLALDQQQFGTWAAIAIHDTSSVVGAGSAYGEEALRVATTIKLTRALWIVPLTLVFSFVYKTKGAKRFPVPLFILFFIGAIILNTYLLEAYFPEVGRFVASLARKGLTLSLFFIGASLTKEVIASVGVRALLQGLFLWILISVGSLAFILLI
>NC_015571.1|WP_013815285.1|282818_284162_-|deoxyguanosinetriphosphate-triphosphohydrolase-family-protein
MTMMQWERLLSDKRVGMEHYHQPKQSAQPWERTDFERDYDRMVFSSPFRRLQNKAQVFPLAGNIFVHNRLTHSLEVSCVGRSLGNNITRGLKARYGELPWESGAISAIVSAACLAHDMGNPPFGHSGERAISAYFREGKGRVWEDAVRKEGGRWEDFLHFEGNANAFRLLTHQFEGRRKGGFALTYSTVASIVKYPYSSEMAGKAGKFGFFATEEDTFLMIAEELGMLCRNEHPVKYARYPLVYLVEAADDICYQIMDIEDAYKLRILTYAETENLFLAFCPEEELRHIRGVLDHITDANEQIAYLRSRVISLLVESCTRVFLDHEDEILSGTFSGTLIGAMEPRLKEAYGACARMAYSKIYVARDVVDVELAGHQIFGALIDKMMQALTNPDHAYSRTLLSRVSTQYNIREESLYGKIQCTLDYISGMTDIYALDLYRKITGMNLR
>NC_015571.1|WP_013815284.1|282041_282758_-|4-hydroxy-tetrahydrodipicolinate-reductase
MKIVLIGYGKMGHVIERIACSRGHEVVLTIDAGEEDRFDSIAFRSADVAIEFTRPDAAYANCSRCMDKSVPVVCGTTGWTERLPVLEERCRREGKTLFWASNFSIGVNLFFSLGRMFARLMSRHDQYRPHLTEIHHVHKLDAPSGTAITLAEGLIAESPSLDAWRLTETPEENELPITSIREGEVPGTHSISYTSEVDRLTICHEAFGREGFALGAVLAAEYAATHKGFLTMNDLISL
>NC_015571.1|WP_004583651.1|280628_282026_-|signal-peptidase-I
MTFHWKDLTPWRRIKGVAITILYLLFCIWAGPFWLIFLPLIVDYYFFHIIKWGWYKNIRNKTLRIICSWVADIIYCVVAVTFIFAFLFQNFAIPTSSLEKTLLIGDYLFVSKLSYGPRSPMTPLGVPLTHNTMPLTGGKSFSDKPLLPYKRLKGFGHVKEGDLVVFNFPAGDTVAVKQPNPDYYMWKKLVGREELWSNPDFYGEIVYRPVDRRDHYVKRCVGMPGQELSIRNNQIYIDGKEQRNPRNMQLNYLVRMSREMSVDLIDELGISYDDVRAASSEELKASVGSNLIDSASNQPQIIYHLPLTQGMLDKLQAEPSFVKAVEEPTPIGPLYPLEYETGWTRDNYGPIVIPAKGMTVRLTPLNLALYSRCIRNFEGNKLVQKADGTVLINGRTADSYTFKMDYYFMMGDNRHNSADSRYWGFVPEDHIVGKPVFIWLSLNKDKSLFGGKIRFGRMMRTVNAD
>NC_015571.1|WP_010956473.1|300640_300904_-|CRISPR-associated-endonuclease-Cas2
MYIILVYDIGEKRVGKMLKLCRKYLNWIQNSVFEGEISEVKLLELKSRAAGIMEKEEDSLIIFSSRQERWLEKEIIGKERSATDIFL
>NC_015571.1|WP_005874853.1|300903_301920_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTYYLFNPGELSRKDNTIRFVPIQEGENGQEQAGQARYIPVEGISDFYVFGSLRANSSLYNFLGSNDIAVHFFDYYENYTGSFMPRDFLLSGKMLLAQASAYKNKKKRLFLARKFIEGAASNMQKNLAYYNNRGKDMQPMMELIDKYSLRLKETTTIEALMGIEGNIRQAYYDAFNLIIDPFEMGVRSKQPPQNEVNALISFGNMMCYTLCLKAIHQSQLNPTISFLHTPGERRYSLCLDISEVFKPILVDRTIFKVMNKRIIQAKHFDKQLNKCILNPSGKKLFVQAFEERLSETIRHRKLNRSVSFRHLVKLECYKIAKDILGIEEYQPFKMYW
>NC_015571.1|WP_005874861.1|301916_302429_-|CRISPR-associated-protein-Cas4
MNTISGTHFNYHQVCRRKLWLFSAGITMEHTSDLVYEGKLIHETTYQQRPERYQELELDGIKIDFYDAKNRVVHEVKKSNKISPAHRLQLLYYLYVLERNGVLGATGILEYPTLRKKEEVILSDIDRERIREIEQEILQIISHEDCPPVIDSGICKNCSYYEFCFSGEEQ
>NC_015571.1|WP_013815296.1|302448_304752_-|CRISPR-associated-helicase/endonuclease-Cas3
MINKESPILAKPSGITLDVHAENVIQEGALLLKGLGCTKEKYFQTTAKQIVQRVELACKYHDIGKRNKIWQDACKKDYKAYLIWKKIHPNKSFEDYTIECREEAGKFLRQTHVRHEFYSIKGLLNNNPPPWLKIAIAAHHRKLSMKHEERWLSSDEDICSVWKDIRRLSNCFFDDRNSVLSDIVIKQYEFAGPRSLLQLADHRASAKEESKDIPDPIAFSYTFPEKWEKRPVQKLVEKHWRDELLLVRAPTGAGKTDAALLWASLQIKHRKADRLIIAMPTRFTTNALALNVSSTLSSTGLYHSSAWTQNFSSKIDNGEIALEQARYYHNQARLLQTPITVCTIDHLLSSLTLCDEEHQTITFALANACLVIDEADFYDQFTQANILVLLEVLKYWKVPILLMSASLPDNIVQEYRKIGYDIKHILEDTSDIERARFSLIEKRDVSEISQMQDLLQLCLDRGSAIIFANTVDRAQAYYQWFLENGHEEEVILYHSRYTETDKIEKEAQLLLRLGRSAWDNDRANGVAILTQIGEMSVNISADIMISDLCPIDRLTQRCGRLCRFSRKIGDLYIIRPMREGNLFPAPYYQNVGPSQKLEPNDALIKTDELLEKGMYSAANLVQLLNKVYANQTVFSTEASCNADRLREMFKANWLINPIEYLDEEIGSTNFWRARNIMPRCRIYIKRPLQSFRNYSDFRRWETDVAIDIPIYVIKKAMRMSDTVCSQVKVCIGKNDYTLIVINAKCYNNVRGLFFSKSVLEEPNFEFL
>NC_015571.1|WP_013815297.1|304741_305758_-|type-I-PGING-CRISPR-associated-protein-Cas7/Csp1
METKKIAGVLVTMVAPFENHMANGGEKLFGNASSIKRRPDGRVYVSGQMQRHVLFSAIDRLNHLDKAKGTTFVSNGDGITNLIEIDLRADLGGFMHTNKGDYSDRRIAPLSVTPATALDTSSVGRDLLVRIRFDKSSDAKNQALATREYSEQDKMNMNFFLDITSVGVSKSFVYKDGLNLGTKYFKHITDDEKKRRVKLFLEATRIMNDYANQARNAVCGEPEKVLIVFDDRLSRKACRYYTAGEKEQANIIKELNECQVKYFIGDDTSDYSVADAYRDAINYLDKATFVDLAEGEEIMTFAEAFECKEKEPQGKKSKKGKDKATSAQNLFAEQQDDQ
>NC_015571.1|WP_013815298.1|305768_307268_-|type-I-PGING-CRISPR-associated-protein-Cas8c/Csp2
MNTNHYYIRYGCAITLYDNHVSERERLTPKELRFSIEKAVSSFRIQAQEPFSPGSKARFSFVKRKDGNTKNGIFLSPHIVTKDMHAQKVWTKASKFLEIDYLGKDNEREGLLKKDNVSMSNIPISGEFLTFGEKDTGRGSAKISVEEQTYGLITTLTTLKPALQVGKDNFCIIPDIPLNQMVDFITLLDKMQITHLSGEAMLGNIDNKGIPHRPKIFRGNFPNSPKSDRMGAIALLGAIGEFAKHAEFSTLAQKVLDSLKGSTLYLITYANAIPFTFHHYIIDLAKEGKLHSIVDSLFYSRLYKKEKRVYGDTDYDRFDFFANRFLQSFNKAAFDDFFSSRVEYPNQIKILFQMFFTKMEKLKTDVIASAQVLGSWLNQVAYFAAKEEADSRISPGNIFEEKAKFLVMMESSIYAAKRGDALIAQILILAGRLSKNEAPKEALLFMEKTITGEIDLSVAKNLLIAYMRIRREEKQRDLNSVKNDDAIPSDINIDDLTNT
>NC_015571.1|WP_013815299.1|307264_308008_-|type-I-PGING-CRISPR-associated-protein-Cas5p
MKYNMKNIDLSILGKDPDLSASIKLHIEPHAPISMVSELPGSYYKALLYPDKHILCGLFENVLGWHFSRKDREIITKEIKNIRKKAKKGYIPPTIRSIFIPLLSDFFELDSVRIVSTDSPFFYNDLWKRAFRRKDAGKIHFGGTQNIDYTLVMDKFRFMCENERALETEEKTDQKEEKFLRENIDRISFFYTTPTNREYLFFEGNYECVIKMDPQLVDLLSKTLPQQNMGYLGNSEGWVTLYLEEKS
>NC_015571.1|WP_013815300.1|308004_308670_-|CRISPR-associated-endoribonuclease-Cas6
MRIELSIKADDSLVSFSHQHLLVGTLQKWLGENDMHGKSISYSFSRLNGGKLVSELNSILFADWANMFVSAHDPELIRRMLAGIRQDPEMFKSLCVREVTVIEDPDMTDREIFFPASPILLKRWREDNGFDHIVYTDEAANALLTENLRKKLQAVGIDDPTATASFVPDKGKAKVMLIDYRGVKNKASWCPIRIIGNAETKLFAWNAGIGNSTGIGFGAIK
>NC_015571.1|WP_102947769.1|308692_308941_-|DUF1661-domain-containing-protein
MVREIKNSRATTKNFLFRFFRKHAPQSEHFRFVFYTPPSPLFYFQCGFRKIPRNDGCYISDFLANKHKKYALITAFRVTLGH
>NC_015571.1|WP_173362815.1|308909_309002_+|DUF1661-domain-containing-protein
MAREFFISRTKTKKFTRHVFRGRRHREVGS

Crispr_ID: NC_015571_7

• CRISPR_ID: NC_015571_7
• CRISPR_location: 604390-605408
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 15 spacers

Consensus repeat of NC_015571_7

Consensus_repeat	Method
GTTTTAATTCCTGTATGGTGCAATTGAAAT	PILER-CR
ATTTCAATTGCACCATACAGGAATTAAAAC	CRISPRCasFinder
ATTTCAATTGCACCATACAGGAATTAAAAC	CRT

spacers of NC_015571_7

>7.1|604420|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
AATATGCCCGCGCTCGGGGTTAAAAAGGGAGCGAA
>7.2|604485|37|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GCCGTGGTTGCCGGCGGCGTAGTCCTTTGCGCCGATT
>7.3|604552|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT
GATGTTCTTGATGTATTATTAATAGTATGTTCTA
>7.4|604616|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT
CAAGTCTCAAGACAAGACGACAAAGAAATAGCTCA
>7.5|604681|45|NC_015571|PILER-CR
ATTAAAACAACATATCATCACTAATAAACAACAGTTCTATGAAGA
>7.6|604756|36|NC_015571|PILER-CR
TCTTTGTCCTGAAATAAAAAGTAGTTTTCGCTACCG
>7.7|604822|34|NC_015571|PILER-CR
AAAGTGATAATGATTCTGAACGACCAGCTTGTTC
>7.8|604886|37|NC_015571|PILER-CR
ACAATGAGCAATCAANTTCGACTATAAGATAAACGTC
>7.9|604953|34|NC_015571|PILER-CR
GCGAGGATGCGCGCGCATAGTAAGTAGCATTCCG
>7.10|605017|36|NC_015571|PILER-CR
TACCGTGTAACCGGTAAGATCCTCGCCGGCGATCGT
>7.11|605083|36|NC_015571|PILER-CR
CCGAAAAGCAGATCACCGCCGTGCTGCCCGCCCCCC
>7.12|605149|37|NC_015571|PILER-CR
TATCCATATTACGCTCGTACTCCTCGAACCAGTTATC
>7.13|605216|36|NC_015571|PILER-CR
GATGAGTAGCCGGGTAGCTGTCATAGGGGGTACGCC
>7.14|605282|37|NC_015571|PILER-CR
CCTTCGAGGCGCCTGCTTTGTCGTCTGCAGGCTGGAA
>7.15|604681|38|NC_015571|CRISPRCasFinder,CRT
CAACATATCATCACTAATAAACAACAGTTCTATGAAGA
>7.16|604749|36|NC_015571|CRISPRCasFinder,CRT
TCTTTGTCCTGAAATAAAAAGTAGTTTTCGCTACCG
>7.17|604815|34|NC_015571|CRISPRCasFinder,CRT
AAAGTGATAATGATTCTGAACGACCAGCTTGTTC
>7.18|604879|37|NC_015571|CRISPRCasFinder,CRT
ACAATGAGCAATCAANTTCGACTATAAGATAAACGTC
>7.19|604946|34|NC_015571|CRISPRCasFinder,CRT
GCGAGGATGCGCGCGCATAGTAAGTAGCATTCCG
>7.20|605010|36|NC_015571|CRISPRCasFinder,CRT
TACCGTGTAACCGGTAAGATCCTCGCCGGCGATCGT
>7.21|605076|36|NC_015571|CRISPRCasFinder,CRT
CCGAAAAGCAGATCACCGCCGTGCTGCCCGCCCCCC
>7.22|605142|37|NC_015571|CRISPRCasFinder,CRT
TATCCATATTACGCTCGTACTCCTCGAACCAGTTATC
>7.23|605209|36|NC_015571|CRISPRCasFinder,CRT
GATGAGTAGCCGGGTAGCTGTCATAGGGGGTACGCC
>7.24|605275|37|NC_015571|CRISPRCasFinder,CRT
CCTTCGAGGCGCCTGCTTTGTCGTCTGCAGGCTGGAA
>7.25|605342|37|NC_015571|CRISPRCasFinder,CRT
GAGCGATGCAGGCTCGTTGGAAGAGGTCGGTATGCAA

CRISPR arrays and Neighbor proteins around NC_015571_7

CRISPR arrays

The CRISPR arrays of NC_015571_7

>merge|NC_015571|7|604390-605408|PILER-CR,CRISPRCasFinder,CRT
ATTTCAATTGCACCATACAGGAATTAAAACAATATGCCCGCGCTCGGGGTTAAAAAGGGAGCGAAATTTCAATTGCACCATACAGGAATTAAAACGCCGTGGTTGCCGGCGGCGTAGTCCTTTGCGCCGATTATTTCAATTGCACCATACAGGAATTAAAACGATGTTCTTGATGTATTATTAATAGTATGTTCTAATTTCAATTGCACCATACAGGAATTAAAACCAAGTCTCAAGACAAGACGACAAAGAAATAGCTCAATTTCAATTGCACCATACAGGAAATTAAAACAACATATCATCACTAATAAACAACAGTTCTATGAAGAATTTCAATTGCACCATACAGGAATTAAAACTCTTTGTCCTGAAATAAAAAGTAGTTTTCGCTACCGATTTCAATTGCACCATACAGGAATTAAAACAAAGTGATAATGATTCTGAACGACCAGCTTGTTCATTTCAATTGCACCATACAGGAATTAAAACACAATGAGCAATCAANTTCGACTATAAGATAAACGTCATTTCAATTGCACCATACAGGAATTAAAACGCGAGGATGCGCGCGCATAGTAAGTAGCATTCCGATTTCAATTGCACCATACAGGAATTAAAACTACCGTGTAACCGGTAAGATCCTCGCCGGCGATCGTATTTCAATTGCACCATACAGGAATTAAAACCCGAAAAGCAGATCACCGCCGTGCTGCCCGCCCCCCATTTCAATTGCACCATACAGGAATTAAAACTATCCATATTACGCTCGTACTCCTCGAACCAGTTATCATTTCAATTGCACCATACAGGAATTAAAACGATGAGTAGCCGGGTAGCTGTCATAGGGGGTACGCCATTTCAATTGCACCATACAGGAATTAAAACCCTTCGAGGCGCCTGCTTTGTCGTCTGCAGGCTGGAAATTTCAATTGCACCATACAGGAATTAAAACGAGCGATGCAGGCTCGTTGGAAGAGGTCGGTATGCAAATTTCAATTGCACCATACAGGAGGTAGTAT

>NC_015571|7|4|604390-605341|PILER-CR
ATTTCAATTGCACCATACAGGAATTAAAAC	AATATGCCCGCGCTCGGGGTTAAAAAGGGAGCGAA
ATTTCAATTGCACCATACAGGAATTAAAAC	GCCGTGGTTGCCGGCGGCGTAGTCCTTTGCGCCGATT
ATTTCAATTGCACCATACAGGAATTAAAAC	GATGTTCTTGATGTATTATTAATAGTATGTTCTA
ATTTCAATTGCACCATACAGGAATTAAAAC	CAAGTCTCAAGACAAGACGACAAAGAAATAGCTCA
ATTTCAATTGCACCATACAGGAAATTAAAA	CAACATATCATCACTAATAAACAACAGTTCTATGAAGAATTTCAA
TTGCACCATACAGGAATTAAAACTCTTTGT	CCTGAAATAAAAAGTAGTTTTCGCTACCGATTTCAA
TTGCACCATACAGGAATTAAAACAAAGTGA	TAATGATTCTGAACGACCAGCTTGTTCATTTCAA
TTGCACCATACAGGAATTAAAACACAATGA	GCAATCAANTTCGACTATAAGATAAACGTCATTTCAA
TTGCACCATACAGGAATTAAAACGCGAGGA	TGCGCGCGCATAGTAAGTAGCATTCCGATTTCAA
TTGCACCATACAGGAATTAAAACTACCGTG	TAACCGGTAAGATCCTCGCCGGCGATCGTATTTCAA
TTGCACCATACAGGAATTAAAACCCGAAAA	GCAGATCACCGCCGTGCTGCCCGCCCCCCATTTCAA
TTGCACCATACAGGAATTAAAACTATCCAT	ATTACGCTCGTACTCCTCGAACCAGTTATCATTTCAA
TTGCACCATACAGGAATTAAAACGATGAGT	AGCCGGGTAGCTGTCATAGGGGGTACGCCATTTCAA
TTGCACCATACAGGAATTAAAACCCTTCGA	GGCGCCTGCTTTGTCGTCTGCAGGCTGGAAATTTCAA
TTGCACCATACAGGAATTAAAAC

>NC_015571|7|7|604390-605408|CRISPRCasFinder
ATTTCAATTGCACCATACAGGAATTAAAAC	AATATGCCCGCGCTCGGGGTTAAAAAGGGAGCGAA
ATTTCAATTGCACCATACAGGAATTAAAAC	GCCGTGGTTGCCGGCGGCGTAGTCCTTTGCGCCGATT
ATTTCAATTGCACCATACAGGAATTAAAAC	GATGTTCTTGATGTATTATTAATAGTATGTTCTA
ATTTCAATTGCACCATACAGGAATTAAAAC	CAAGTCTCAAGACAAGACGACAAAGAAATAGCTCA
ATTTCAATTGCACCATACAGGAAATTAAAA	CAACATATCATCACTAATAAACAACAGTTCTATGAAGA
ATTTCAATTGCACCATACAGGAATTAAAAC	TCTTTGTCCTGAAATAAAAAGTAGTTTTCGCTACCG
ATTTCAATTGCACCATACAGGAATTAAAAC	AAAGTGATAATGATTCTGAACGACCAGCTTGTTC
ATTTCAATTGCACCATACAGGAATTAAAAC	ACAATGAGCAATCAANTTCGACTATAAGATAAACGTC
ATTTCAATTGCACCATACAGGAATTAAAAC	GCGAGGATGCGCGCGCATAGTAAGTAGCATTCCG
ATTTCAATTGCACCATACAGGAATTAAAAC	TACCGTGTAACCGGTAAGATCCTCGCCGGCGATCGT
ATTTCAATTGCACCATACAGGAATTAAAAC	CCGAAAAGCAGATCACCGCCGTGCTGCCCGCCCCCC
ATTTCAATTGCACCATACAGGAATTAAAAC	TATCCATATTACGCTCGTACTCCTCGAACCAGTTATC
ATTTCAATTGCACCATACAGGAATTAAAAC	GATGAGTAGCCGGGTAGCTGTCATAGGGGGTACGCC
ATTTCAATTGCACCATACAGGAATTAAAAC	CCTTCGAGGCGCCTGCTTTGTCGTCTGCAGGCTGGAA
ATTTCAATTGCACCATACAGGAATTAAAAC	GAGCGATGCAGGCTCGTTGGAAGAGGTCGGTATGCAA
ATTTCAATTGCACCATACAGGAGGTAGTAT

>NC_015571|7|4|604390-605408|CRT
ATTTCAATTGCACCATACAGGAATTAAAAC	AATATGCCCGCGCTCGGGGTTAAAAAGGGAGCGAA
ATTTCAATTGCACCATACAGGAATTAAAAC	GCCGTGGTTGCCGGCGGCGTAGTCCTTTGCGCCGATT
ATTTCAATTGCACCATACAGGAATTAAAAC	GATGTTCTTGATGTATTATTAATAGTATGTTCTA
ATTTCAATTGCACCATACAGGAATTAAAAC	CAAGTCTCAAGACAAGACGACAAAGAAATAGCTCA
ATTTCAATTGCACCATACAGGAAATTAAAA	CAACATATCATCACTAATAAACAACAGTTCTATGAAGA
ATTTCAATTGCACCATACAGGAATTAAAAC	TCTTTGTCCTGAAATAAAAAGTAGTTTTCGCTACCG
ATTTCAATTGCACCATACAGGAATTAAAAC	AAAGTGATAATGATTCTGAACGACCAGCTTGTTC
ATTTCAATTGCACCATACAGGAATTAAAAC	ACAATGAGCAATCAANTTCGACTATAAGATAAACGTC
ATTTCAATTGCACCATACAGGAATTAAAAC	GCGAGGATGCGCGCGCATAGTAAGTAGCATTCCG
ATTTCAATTGCACCATACAGGAATTAAAAC	TACCGTGTAACCGGTAAGATCCTCGCCGGCGATCGT
ATTTCAATTGCACCATACAGGAATTAAAAC	CCGAAAAGCAGATCACCGCCGTGCTGCCCGCCCCCC
ATTTCAATTGCACCATACAGGAATTAAAAC	TATCCATATTACGCTCGTACTCCTCGAACCAGTTATC
ATTTCAATTGCACCATACAGGAATTAAAAC	GATGAGTAGCCGGGTAGCTGTCATAGGGGGTACGCC
ATTTCAATTGCACCATACAGGAATTAAAAC	CCTTCGAGGCGCCTGCTTTGTCGTCTGCAGGCTGGAA
ATTTCAATTGCACCATACAGGAATTAAAAC	GAGCGATGCAGGCTCGTTGGAAGAGGTCGGTATGCAA
ATTTCAATTGCACCATACAGGAGGTAGTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_004583937.1|600572_601055_-|CinA-family-protein	unknown	unknown	gnl|CDD|334938
NC_015571.1|WP_013815513.1|607271_609467_-|ribonuclease-R	unknown	unknown	gnl|CDD|273947
NC_015571.1|WP_143733906.1|613075_613168_-|DUF1661-domain-containing-protein	unknown	unknown	unknown
NC_015571.1|WP_158309336.1|613136_613247_+|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_013815508.1|598247_599111_-|hypothetical-protein	unknown	unknown	gnl|CDD|225543
NC_015571.1|WP_013815505.1|595766_596192_+|3-dehydroquinate-dehydratase	unknown	unknown	gnl|CDD|376496
NC_015571.1|WP_013815517.1|613571_616322_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|379720
NC_015571.1|WP_005874497.1|602497_602752_-|30S-ribosomal-protein-S20	unknown	unknown	gnl|CDD|178943
NC_015571.1|WP_013815510.1|601054_602080_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl|CDD|236585
NC_015571.1|WP_005874482.1|597024_597528_+|thiol-peroxidase	unknown	unknown	gnl|CDD|179055
NC_015571.1|WP_013815515.1|611065_612916_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NC_015571.1|WP_013815512.1|605647_606733_+|IS5-family-transposase	unknown	unknown	gnl|CDD|377531
NC_015571.1|WP_013815509.1|599120_600539_-|PDZ-domain-containing-protein	unknown	unknown	gnl|CDD|379281
NC_015571.1|WP_013815514.1|609520_611032_-|GH3-auxin-responsive-promoter-family-protein	unknown	unknown	gnl|CDD|377019
NC_015571.1|WP_021662893.1|596310_596943_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|226607
NC_015571.1|WP_004583934.1|597723_598215_-|nucleoside-deaminase	unknown	unknown	gnl|CDD|223663
NC_015571.1|WP_012457484.1|617166_617385_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815504.1|594723_595650_-|tyrosine-recombinase-XerD	unknown	unknown	gnl|CDD|274043
NC_015571.1|WP_080580305.1|606832_607081_+|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_005875456.1|617417_618062_+|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl|CDD|273138

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_004583937.1|600572_601055_-|CinA-family-protein	gnl|CDD|334938	pfam02464, CinA, Competence-damaged protein. CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some stage in the process of transformation. This Pfam family consists of putative competence-damaged proteins from the cin operon. Some members of this family have nicotinamide mononucleotide (NMN) deamidase activity.	4.74078e-68
NC_015571.1|WP_013815513.1|607271_609467_-|ribonuclease-R	gnl|CDD|273947	TIGR02063, Ribonuclease_R, ribonuclease R. This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA].	0
NC_015571.1|WP_158309336.1|613136_613247_+|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.000587159
NC_015571.1|WP_013815508.1|598247_599111_-|hypothetical-protein	gnl|CDD|225543	COG2996, COG2996, Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only].	3.87914e-67
NC_015571.1|WP_013815505.1|595766_596192_+|3-dehydroquinate-dehydratase	gnl|CDD|376496	pfam01220, DHquinase_II, Dehydroquinase class II.	2.7826e-74
NC_015571.1|WP_013815517.1|613571_616322_+|TonB-dependent-receptor	gnl|CDD|379720	pfam14905, OMP_b-brl_3, Outer membrane protein beta-barrel family. This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.	1.5699e-26
NC_015571.1|WP_005874497.1|602497_602752_-|30S-ribosomal-protein-S20	gnl|CDD|178943	PRK00239, rpsT, 30S ribosomal protein S20; Reviewed.	5.59069e-20
NC_015571.1|WP_013815510.1|601054_602080_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl|CDD|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	0
NC_015571.1|WP_005874482.1|597024_597528_+|thiol-peroxidase	gnl|CDD|179055	PRK00522, tpx, thiol peroxidase.	3.72904e-103
NC_015571.1|WP_013815515.1|611065_612916_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.954e-160
NC_015571.1|WP_013815512.1|605647_606733_+|IS5-family-transposase	gnl|CDD|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.2052e-23
NC_015571.1|WP_013815509.1|599120_600539_-|PDZ-domain-containing-protein	gnl|CDD|379281	pfam13590, DUF4136, Domain of unknown function (DUF4136). This domain is found in bacterial lipoproteins. The function is not known.	1.44997e-12
NC_015571.1|WP_013815514.1|609520_611032_-|GH3-auxin-responsive-promoter-family-protein	gnl|CDD|377019	pfam03321, GH3, GH3 auxin-responsive promoter.	4.69766e-134
NC_015571.1|WP_021662893.1|596310_596943_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	1.98251e-48
NC_015571.1|WP_004583934.1|597723_598215_-|nucleoside-deaminase	gnl|CDD|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	4.18496e-55
NC_015571.1|WP_013815504.1|594723_595650_-|tyrosine-recombinase-XerD	gnl|CDD|274043	TIGR02225, Tyrosine_recombinase_XerD, tyrosine recombinase XerD. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerD, one of two closely related chromosomal proteins along with XerC (TIGR02224). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and with homologs of XerD on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerD, as some apparent XerD examples score below the trusted and noise cutoff scores. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	2.86564e-124
NC_015571.1|WP_080580305.1|606832_607081_+|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	9.17128e-05
NC_015571.1|WP_005875456.1|617417_618062_+|pyridoxamine-5'-phosphate-oxidase	gnl|CDD|273138	TIGR00558, Pyridoxine/pyridoxamine_5'-phosphate_oxidase, pyridoxamine-phosphate oxidase. This model is similar to Pyridox_oxidase from Pfam but is designed to find only true pyridoxamine-phosphate oxidase and to ignore the related protein PhzG involved in phenazine biosynthesis. This protein from E. coli was characterized as a homodimer with two FMN per dimer. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine].	2.38195e-108

Protein sequences

>NC_015571.1|WP_005874497.1|602497_602752_-|30S-ribosomal-protein-S20
MANHISSEKRIRQTNARRLHNRYYARTARNAVKAFRALTDRTEAEKKYPVLASMLDRLAGKNIIHKNKAANLKSKLARRINTLA
>NC_015571.1|WP_013815510.1|601054_602080_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MKKDIIILGIESSCDDTSAAVVRNETMLSNVIAGQAVHNAYGGVVPELASRAHQQNIVPVVSEAIKRAGIRKEEIDAIAFTRGPGLLGSLLVGTSFAKGLSLSLGIPMLEVNHLHAHVLANFLREPGEESQHPSFPFLCLLVSGGNSQIILVRSPYDMEVIGQTIDDAAGEAFDKCAKVMGLGYPGGPIVNKLASEGNPDAFRFARPLVSGYDYSFSGLKTSFLYTLRDKLAEDPDFIEKNKADLCASLQHTVIDILMKKLRQAAKDHSIKQVALAGGVSANTGLRDAFHDHARRYGWTVFIPKFAYTTDNAAMVAISGYYKYLQGDFCPIDAVPFSRITV
>NC_015571.1|WP_004583937.1|600572_601055_-|CinA-family-protein
MDYPVISELAKLLTERGLTLATAESCTGGTIASALTHCPGASTFFRGSVVAYQNDIKIRLLGVSQADIESHTVVSEPVARSMAVGVCRLLDANIGIATTGIAGPSGGSDQVPVGTVWIALVIGEDTFAHCLHLSGTREEVIAQATDQALLTIFDLCKNKL
>NC_015571.1|WP_013815509.1|599120_600539_-|PDZ-domain-containing-protein
MKMNRLFAIAIATLLSATATSAQSATGSDQVCRIGMQYQISYNEHWGANRPVIITVEPGSAADVAGLKPGDVIEKVAGKATASLDEVDFQKLLISGNTTRLEVSDLSGTKQITLGRDCQSRYILSERQLARSFSFYSLQDASDRRIVRPYKVKTSTKADFTNLRTYSFAASSPDNEEIDIAVYKEVGKYLSAMGMKETLNNPDVIVDCYYLFDNNKLFTSFNSSAPHNSWQYSPRDKKMISIPIMPAGTQEINAPYVIQLGVRLINARNNLQVFWQCESNDFLSTPLELAEYARYNVPLMMMEFPFIRYRENPTFRLRSQRYFYTGLYYQANDLSLVAAVDPDSPAAKAGLKAGDRIISINGIPALSGSEEYSSAYKEFIKKSMKYRTEEDTFTDANGLAGCRYWSPKNYEKIARMMAQPKYKPAFAYLFFFRSYVNDQQITSCVFQVQRDGMPESILVQPVLRDESSVTLE
>NC_015571.1|WP_013815508.1|598247_599111_-|hypothetical-protein
MKRSKYQLGRIGRLTIDRIVSIGAYLDGGDTDILLPNRYLPSDAAPGMEVEVFVYHDNEGRLIATTMRPLVEVGQVALLHAVSVTDSGAYMEWGIHKDLFVPFREQTQLIREGGRYFVYAYIDHVSGKIVGSAKLSKHLGNIPPSYSPGDKVSALVYERIDPGYRMIVDHTHWGMIYSDTLPMPLAIGAQVKAFVIRLRDDGKIDLSLKPIGYDRIDSESERLLHMLQRRGGRLPIGDKSSPEEIMQHTGMSKKTFKMAVGMLYRRRLIRIAPTAIALNETVSTPEA
>NC_015571.1|WP_004583934.1|597723_598215_-|nucleoside-deaminase
MHNTMNHTEQDKEMMREAIRLADESVANGGGPFGAVIVKDGEIIAATSNRVTLDNDPTAHAEVNCIRMACKRLGTFDLSGCTIYTSCEPCPMCLGAIYWARIDRIFYGNNRQDAADIGFDDDFIYQELARPMDNRSTPIIPILQDEALHSFRLWTEKTDKTEY
>NC_015571.1|WP_005874482.1|597024_597528_+|thiol-peroxidase
MATVTLQGKININTNGQLPGVGSVAPDFKAVRADLSEVSLSEFKGKRVVINIFPSIDTGVCAASVRRFNQEASSLDNTVVLCLSKDLPFAQARFCGAEGLDKVITVSAFRCDCFEKGYGLLMTDGPLKGLLARAVVVVDENGKIIYEELVPEITQEPNYEAAIAALK
>NC_015571.1|WP_021662893.1|596310_596943_+|class-I-SAM-dependent-methyltransferase
MTIDEYIATHTSAEPPILQKLDRDAHLHLMRPRMLSGHLQGRFLSMISHLMRPRRILEIGTYTGYASLCLAEGLTPDGLLHTLERDDEMEDFIRRYLEASDLGGKIRLHIGEALDLLPDLVKNERFDLIYMDADKRQYTLYYEMIIDHLPPGALILADNTLWDGKVVAEPLPTDSQTQGILRFNEMVLQDERVENLIVPMRDGLSMIRVR
>NC_015571.1|WP_013815505.1|595766_596192_+|3-dehydroquinate-dehydratase
MKLIHIINGPNLASLGKREPEIYGTRSFDAYLEDLRDLYPDATISYYQSNHEGELIDALYRAEQSGAVGVVLNAGGYTHTSIALLDAIRAISIPVVEVHISSIFAREEYRRQSMIAPACRGVISGFGLESYRLAVDFLVRE
>NC_015571.1|WP_013815504.1|594723_595650_-|tyrosine-recombinase-XerD
MIEDSLSKRYKSYLSLELHLTPNSVDAYLKDLSKLDSYLTAENISFREVSYENLQHFVAELYDLGISARSIARIISGVKSFFRFLVLEEYIEADPTELLEGPRIGVHLPTVLTIEEVDRLIGSIDPAAQGAQRNRAILEILYSCGLRVSELTSLKFSNLFLNESFLRIDGKGRKQRLVPMSETAITELKRYLSDPERPTPILGQEEYVFLSNRGKAISRIMVFVMIKKLAEEAGITKSISPHTFRHSFATHLLEGGANLQAIQLMLGHENIATTEIYTHIDRETLRHEIETYHPRNQSYRRSGSEADQ
>NC_015571.1|WP_013815512.1|605647_606733_+|IS5-family-transposase
MAYQSKNTDEHVTFADALLSKRYRKAQNDFLNQVDTLIDWRPIRTLINKKYTKRQNAIGAPAYDVILLFKMLLLETWYNLSDCALEERINDSITFSRFLGLKMEEVSPDHSTISRFRSALTELGLMDKLLAQFNKQLSRHHISVREGVLVDASLVETPHKPNGSITIEVADDREDNRSEAEKEAEEDYQKQVVRRRKGTDEEARWVYKQKRYHYGYKKHCPANVQGIVQKVITTAANRSDTKEFIPLLEGANIPQGTAVLADKGYACGENRSYLQTHHLQDGIMHKAQRNRALTEEEKQGNKAISPIRSTIERTFGSIRRWFHGGRCRYRGLAKTHTQNILESIAFNLYRTPGIIMSSSVG
>NC_015571.1|WP_080580305.1|606832_607081_+|DUF1661-domain-containing-protein
MRRTPLPSTSLFCKGLLKSAIGQEKTNRKSEESGSGNPENTREKNFVLVREQKNSRTKTKKFSDHVLRSYTRQNLRTKKRAR
>NC_015571.1|WP_013815513.1|607271_609467_-|ribonuclease-R
MSKKKDKSKTKARKGDAPRINRAGRRNKRMTKEEMRNAILDIFQSNPQSVMNYKQVSHLMGVEAAPQKLMVNSLMEDMAVDDILHEIERGRYRYNALGLIVIGTFERRFNGRNSFIPEGGGTPIFIAERNSAHAMDGDKVKVQLFAKRRGRAPEAAVIEIIEQKQATFVGKIQINRDFAFLVTEDRTLANDIFIPKDNLGNAKNGDKVIVRILEWPEQSKNPIGEVQAVLGPAGDNDAEMNAILAEFGLPYVYPQEVEEAADRLDGKITEEELARREDFRSVLTFTIDPKDAKDFDDAISFRPLEDDCYEVGVHIADVSHYVTEGGIIDQEAYNRATSIYLVDRTIPMLPERLCNDLCSLRPDEEKYAYSCIFRMNDEAKVLDYRICHSVIKSDRRFAYEEAQAVIETGEGDCKEAILKLNELAQRLRKERFQNGAIAFERKEVRFEIDEKGRPLGVIVKESKEANKLIEEFMLLANRTVARHIGEETQGKRAKTFVYRIHDLPDPDKLETLSDFIRRFGYKLRTTGSNVEVSKSINSLLDNIQNKPEENLISTVAIRSMAKAIYSTDNIGHYGLAFDFYTHFTSPIRRYPDLMVHRLLTKYLSGGSSVDKNDYEEKCKHSSAMEQLAASAERASIKYKQVEFMSEHLGKVFDGVISGVTEWGLYVELKENMCEGLIPIRCLDDDYYEYDDKNFCLIGRRYRHRYSLGDAITVRVAQANLDRKQLDFEPVS
>NC_015571.1|WP_013815514.1|609520_611032_-|GH3-auxin-responsive-promoter-family-protein
MDYKTRIIYALLKSRLKTIDTYASRAEEIQDRQLRRILSSAAYTSTGIRYGFSRISSKECFARNVPVSDYESTQAEIERMLRGEKGVLCPGRCTWFAKSSGTTNSKSKFIPVPYRHLHYCHYQGAKDSLSLYLHNRPDSRFFTTKGLVLGGSHAPVSMNADIQVGDLSAILVENMPVLGNCMRVPSKETLLMDEWTEKLKAVVREVAHVRVGSLSGVPSWVLVLIKDILAATGRETLSDVWPELEVFFHGGISFAPYRAQYEKLIPSSRMQYMETYNASEGFFGIQDDPKDSGMLLMLDYGVYYEFIPMEHFGRPEAEAIPLEGVEKGRNYAMIISTLGGLYRYVLGDTVRFTSVKPYKIVITGRTKHYINAFGEELMVDNSDKALAATCKRFGVQAVDYTVAPHFFSEEGKGRHDWLIEFVSAPADPNAFAKALDAELQTLNSDYEAKRYADMTLLPLSLTIARSGLFHDWLTEQGKLGGQHKVPRLSNTPEIMRSILEMNS
>NC_015571.1|WP_013815515.1|611065_612916_-|ABC-transporter-ATP-binding-protein
MKHFFSAIRRFVPPYKKYVAWSVVANTLSALLNLLSFSLIMPILRILFRIDRQVTTYMPMDGIDWGSMDGWKAAGAALSNNFSWYVSQLIEVRGASFTLIMLGIYLVVMTFLKVASMYLGFYSMIPLRTGVVRDIRNQINDKILGLPLSFFSEERKGDIMARISGDVNEIETSVISSLDMLLKNPILISIYLIGMILISWQLTLFVFILLPIAGGLMGKVGKTLKRKSLEGQNQWGSLMSQIEETLGGLRIIKAFNAEKKMQDRFHRANEQFRRTTMKVFRRQQLAHPMSEFLGTTTIAIVLWYGGTLILNNTSEIDASTFIYYLVIFYSLINPVKELSKASYAIEKGLASMSRVDKILMAENDIKDPEQPHPVVFEEEVVYDHVWFRYGEDWVLRDVCLTIPKGKTVALVGQSGSGKSTIVDLLPRFYDIRQGRVLIDGMDVRDVKLHELRELIGNVNQEAILFNDTVFNNIAFGKENATAEEVEHAARIANAHDFIMQMPEGYQSNIGDRGGKLSGGQRQRISIARAILKNPPILILDEATSALDTESERLVQNAIEKLMANRTAIVIAHRLTTIRNADIICVLHEGRIVEQGRHDELYALGGYYTKLCDMNAE
>NC_015571.1|WP_143733906.1|613075_613168_-|DUF1661-domain-containing-protein
MVRKFFASRAKTKNFSRHVFTIHARAFFQT
>NC_015571.1|WP_158309336.1|613136_613247_+|DUF1661-domain-containing-protein
MAREAKNFRTKTKKFRRVFSPKIAPQSHHFWFVISL
>NC_015571.1|WP_013815517.1|613571_616322_+|TonB-dependent-receptor
MLLASLGFVGLEAQQAGVAGRVLDEEGNPMIQANVQLVQSTGQVAVAAGATNEKGLFSLKTSQEGDYILRVSYVGYTTHDEKISLRNGQTITLKDISMNEDARLLQSVMVQAKAAEVVVRNDTLEFNAGSYTVAQGASIEELIKKLPGAEIGSDGKITINGKDISKILVDGKEFFSKDPQVAIKNLPADMVNKVQVLNKLSELSRMSGFDDGEEETVINLTVKPEKKKGLFGTLQAGYGTDQRYMAGGNVNRFDGNKQWTLIGSANNTNNMGFSEMSSEMGSMTFFSLQGGGRRGFGNSGGVTSSSMLGGNFSVEFSSALNTGGDARYGYNDKAIETTKRVENILAEGNTYMDENILERSFSHNGQARFRMQWKPSEHTEVVFEPDLSISKIDGFFNDTYETKDATGISINKGSIHQTTQGNNFRLNGELDISHKLNDEGRTISASVSGGLTDEDGDGIYQAVLQNVETNQKQFNDNSNLQYRLRLSYVEPLGKNYFAQAILNRRFSRRNSDREVYRLGDDGQYSILDSQYGLSYSNEFTQYRIGLNLKKIAKTWDYTVGFNVDPNRTVSYRNVAGVEQDKLAFNRVNLSPMLRINYKPSRTTNLRVDYRGRTTQPSINQIAPVQDITNPLFVTEGNPGLKPSYSNNVMAMFSDFDAKSQRAFNIVFFGNYTFDDIVPNTHYDPSTGIRTTRYENASGTWQANLHGTLSLPLKNRAFSFRMSLFNRLAEGQSFINDDKNKALSFRTRERLTLTYRNNWIDTSIGGNIGFYMANNSLSGQKDSRTYDFGGNYQVALTLPYGFRIDSDVEYNTNSGYSGGFSLDEWLWNASLSYSFLRDKAGTLRVKGYDILGQRSSISRSATAINIEESMSNTIGRYVMVDFIYRFNAFSGGGSRSDHQRGNMNRPGPPFGGGRRPS
>NC_015571.1|WP_012457484.1|617166_617385_-|hypothetical-protein
MPFELSFQKSHGSPAAGHKDKPIAPLFYDRQVGQTALIGQVFFLIRGLDSRGREDHFEQFLTWFVKQNPYLL
>NC_015571.1|WP_005875456.1|617417_618062_+|pyridoxamine-5'-phosphate-oxidase
MDLHFENIRREYDKRSLSASDLTPTPFDLVTRWLQDAVEAKTYEPTAVIVGTATPDGHPSTRTVLLKEFMNNEFIFYSNYESRKGQQMAANPHVCLTFLWHELERQIHVEGDVRILEPELSDAYFATRPYKSRVGARISPQSRPIPGRSFIVQEFMKESLKYAGRTVPRPDTWGGFAVKPVRIEFWQGRESRLHDRFLYELRPDASWSVHRLAP

Crispr_ID: NC_015571_8

• CRISPR_ID: NC_015571_8
• CRISPR_location: 679139-679231
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015571_8

Consensus_repeat	Method
CTCTACCCTTTATAGTATAACCCC	CRISPRCasFinder

spacers of NC_015571_8

>8.1|679163|45|NC_015571|CRISPRCasFinder
CCATGACTTTATAGTATCAAGTCTCCATACTTTATACTTAAAAGT

CRISPR arrays and Neighbor proteins around NC_015571_8

CRISPR arrays

The CRISPR arrays of NC_015571_8

>merge|NC_015571|8|679139-679231|CRISPRCasFinder
CTCTACCCTTTATAGTATAACCCCCCATGACTTTATAGTATCAAGTCTCCATACTTTATACTTAAAAGTCTCCACCCTTTATAGTATAACCCC

>NC_015571|8|8|679139-679231|CRISPRCasFinder
CTCTACCCTTTATAGTATAACCCC	CCATGACTTTATAGTATCAAGTCTCCATACTTTATACTTAAAAGT
CTCCACCCTTTATAGTATAACCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_013815555.1|674875_676732_-|methylmalonyl-CoA-mutase-small-subunit	unknown	unknown	gnl|CDD|273191
NC_015571.1|WP_005875129.1|669363_670023_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222
NC_015571.1|WP_013815554.1|671452_671845_+|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815560.1|682975_684757_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815558.1|681024_681696_-|M15-family-metallopeptidase	unknown	unknown	gnl|CDD|350617
NC_015571.1|WP_013815559.1|681727_682951_-|HAD-IIB-family-hydrolase	unknown	unknown	gnl|CDD|319818
NC_015571.1|WP_013815562.1|688037_690278_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl|CDD|223394
NC_015571.1|WP_021662723.1|680434_680854_+|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013815550.1|666779_668042_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223650
NC_015571.1|WP_043890020.1|676973_678500_+|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|275036
NC_015571.1|WP_005874254.1|679418_679886_+|HU-family-DNA-binding-protein	unknown	unknown	gnl|CDD|273496
NC_015571.1|WP_043890019.1|670931_671456_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
NC_015571.1|WP_013815561.1|684792_687780_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NC_015571.1|WP_013815563.1|690345_691767_-|cardiolipin-synthase	unknown	unknown	gnl|CDD|234967
NC_015571.1|WP_013815551.1|670041_670449_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_148271470.1|691999_692176_+|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_012457513.1|668064_669339_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223650
NC_015571.1|WP_021664877.1|679947_680394_+|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_004585637.1|672699_674847_-|methylmalonyl-CoA-mutase	unknown	unknown	gnl|CDD|236508
NC_015571.1|WP_023847485.1|672042_672297_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_013815555.1|674875_676732_-|methylmalonyl-CoA-mutase-small-subunit	gnl|CDD|273191	TIGR00642, mmCoA_mut_beta, methylmalonyl-CoA mutase, heterodimeric type, beta chain. The adenosylcobalamin-binding, catalytic chain of methylmalonyl-CoA mutase may form homodimers, as in mitochondrion and E. coli, or heterodimers with a shorter, homologous chain that does not bind adenosylcobalamin. This model describes this non-catalytic beta chain, as found in the enzyme from Propionibacterium freudenreichii, for which the 3-dimensional structure has been solved. [Central intermediary metabolism, Other].	0
NC_015571.1|WP_005875129.1|669363_670023_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.08758e-105
NC_015571.1|WP_013815558.1|681024_681696_-|M15-family-metallopeptidase	gnl|CDD|350617	cd14840, D-Ala-D-Ala_dipeptidase_Aad, D-Ala-D-Ala dipeptidase (includes Lactobacillus plantarum Aad peptidase). D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. This subfamily includes Lactobacillus Aad peptidase and belongs in the MEROPS peptidase family M15, subfamily D.	1.35148e-70
NC_015571.1|WP_013815562.1|688037_690278_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl|CDD|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	2.93763e-179
NC_015571.1|WP_013815550.1|666779_668042_-|ABC-transporter-permease	gnl|CDD|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	8.3335e-35
NC_015571.1|WP_043890020.1|676973_678500_+|T9SS-type-A-sorting-domain-containing-protein	gnl|CDD|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	0.000196987
NC_015571.1|WP_005874254.1|679418_679886_+|HU-family-DNA-binding-protein	gnl|CDD|273496	TIGR01201, HU_rel, DNA-binding protein, histone-like, putative. This model describes a set of proteins related to but longer than DNA-binding protein HU. Its distinctive domain architecture compared to HU and related histone-like DNA-binding proteins justifies the designation as superfamily. Members include, so far, one from Bacteroides fragilis, a gut bacterium, and ten from Porphyromonas gingivalis, an oral anaerobe. [DNA metabolism, Chromosome-associated proteins].	1.60545e-56
NC_015571.1|WP_043890019.1|670931_671456_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	4.01896e-39
NC_015571.1|WP_013815561.1|684792_687780_-|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.74567e-11
NC_015571.1|WP_013815563.1|690345_691767_-|cardiolipin-synthase	gnl|CDD|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	6.88074e-150
NC_015571.1|WP_148271470.1|691999_692176_+|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	5.65596e-07
NC_015571.1|WP_012457513.1|668064_669339_-|ABC-transporter-permease	gnl|CDD|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	3.21075e-30
NC_015571.1|WP_013815559.1|681727_682951_-|HAD-IIB-family-hydrolase	gnl|CDD|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.29143e-61
NC_015571.1|WP_004585637.1|672699_674847_-|methylmalonyl-CoA-mutase	gnl|CDD|236508	PRK09426, PRK09426, methylmalonyl-CoA mutase; Reviewed.	0

Protein sequences

>NC_015571.1|WP_043890020.1|676973_678500_+|T9SS-type-A-sorting-domain-containing-protein
MKKRLLSLCMALAMLPIAMCAQGTTQSSHHKLGSNIDYPINRLSPDGRYMGGWKNGVSYVYDTQMNQTLTTLGGDNLTVYLKSINNDGSIWASRIDNEGIKYGLYKDGKWTDLPKPEGFSGGWLRHVTPDQKYTVNSYTNSLPDMTLISDAFLYERKEDGTYRYRKLIKPKNDCWTESEVFHVDPMQISNDGRIVLGHMVDGLSKYIFPIIWERNAAGEYEYRIKGESFCFNLDQPSPGNPPIEEEMVTAEPGTPEYEEQLAQYYAAVEQWNALAAAFWTGKALHGYPFMDNQGTTIGTALFTGEQDKGSQPLLLSIADDSYALIEYYKTEPFMVTSNGTAFLLNRFMDGIHHNVMYTLGSNEVIPFDKWLKAEYDLTLENEYLHGFKVFVGEPAMSDDGKTLAFTLKFPNGTYKNHYYRLNKSLNLPTSMNKLLSTNPFRVYSSGKTLYTGNSTPCDIRIVNTNGQGVAKAENVVSSLDLKHLSAGIYVAAITRDKKTEFFKIVLAD
>NC_015571.1|WP_013815555.1|674875_676732_-|methylmalonyl-CoA-mutase-small-subunit
MAKEKEKLFSEFPPVSREAWIDKITADLKGVPFEKKLVWRTNEGFNVNPFYRREDIEDLKTTTSLPDEYPYVRSTRMHNEWLVRQDIVVGDNVAEANEKALDLLNKGVDSLGFYLKKVHINVDTLAALLKDIELTAVELNFNCCITRAADLLSAFSAYVKKVAADPNKCRGSVSYDPFKKQLVRGVSNPDWVKMTLPVMDAARELPAFRVLNVNAVNLSDAGAFITQELGYALAWGAELLDKLTDAGYKPEEIASRIKFNFGIGSNYFMEIAKFRAARWLWAQIVGSYGDQYKNETAKIHQHATTSMWNKTVFDAHVNLLRTQTETMSAAIAGVDSITVLPFDVTYQQSDDFSERIARNQQLLLKEECHFDKVIDPSAGSYYIETLTNSIGEEAWKLFLSVEDAGGFTQAAETASIQKAVNASNIKRHQSVATRREIFLGTNQFPNFTEVAGDKITLAQGEHDCNCVKSIEPLNFSRGASEFEALRLATEKSGKTPVVFMLTIGNLAMRLARSQFSSNFFGCAGYKLIDNLGFKSVEEGVDAALAAKADIVVLCSSDDEYAEYAPAAFDYLAGRAEFVVAGAPACMADLEAKGIRNYVHVKSNVLETLRAFNDKFGIR
>NC_015571.1|WP_004585637.1|672699_674847_-|methylmalonyl-CoA-mutase
MKPNYKDIDIKSAGFVAKDATRWAEEKGIVADWRTPEQIMVKPLYTKDDLEGMEHLDYVSGLPPFLRGPYSGMYPMRPWTIRQYAGFSTAEESNAFYRRNLASGQKGLSVAFDLATHRGYDADHPRVVGDVGKAGVSICSLEDMKVLFDGIPLSKMSVSMTMNGAVLPILAFYINAGLEQGAKLEEMAGTIQNDILKEFMVRNTYIYPPEFSMRIIADIFEYTSQNMPKFNSISISGYHMQEAGATADIEMAYTLADGMQYLKAGIDAGIDVDAFAPRLSFFWAIGVNHFMEIAKMRAARLLWAKIVKSFGAKNPKSLALRTHSQTSGWSLTEQDPFNNVGRTCIEAMAAALGHTQSLHTNALDEAIALPTDFSARIARNTQIYIQEETLVCKEIDPWGGSYYVESLTNELVHKAWTLIKEVQEMGGMAKAIETGLPKLRIEEAAARTQARIDSHQQVIVGVNKYRLPKEDPIDILEIDNTAVRKQQIERLNDLRSHRDEKAVQEALEAITKCVETKEGNLLDLAVKAAGLRASLGEISDACEKVVGRYKAVIRTISGVYSSESGEDKDFAHAKELAEKFAKKEGRQPRIMIAKMGQDGHDRGAKVVATGYADCGFDVDMGPLFQTPEEAARQAVENDVHVMGVSSLAAGHKTLIPQVIAELEKLGRPDILVTAGGVIPAQDYDFLYQAGVAAIFGPGTPVAYSAAKVLEILLEE
>NC_015571.1|WP_023847485.1|672042_672297_-|hypothetical-protein
MSKHLTDSERLHIVKEYLGSTRSKYAIEKKYNIAQGLIKDWLRKFGLEYKILPEQTMEASPNPNSDLTPGEKEELEQLRKKFVS
>NC_015571.1|WP_013815554.1|671452_671845_+|hypothetical-protein
MKQNIEDKKLKELFRQLPKQPAGLKQRFDVMRAVREEAARRERRAHRLFGIAMVGVCVLAVVVFVVLGSKGLFSGLDFDSLVQDRFFRNPFTGLGSDIAGAPLIFLSVVVLFGLFLYELYRNTKHRDTKS
>NC_015571.1|WP_043890019.1|670931_671456_+|sigma-70-family-RNA-polymerase-sigma-factor
MEKQSDSYYISAVQAGDTESFAPLVERYSDMLHALLSRLLQDEEDAADLLQDTFVKAFRHIGRFDGRSSFSTWIYRIAYNEAIDHLRRRKAYVTDRVEELPDVPDEDLEPSGEDPELLQQALDSLPAADKALLLMFYSDDLSVRDIAEVTGMTESNVKVKLHRLRAKLYKMMRK
>NC_015571.1|WP_013815551.1|670041_670449_-|hypothetical-protein
MNLESVLVPAVVFYFIFKIFELYVRRGERLRLIEKLDSLLSPERNADLTQLTSSFSTRDNQGLGIKVGFMMVGMGIGLLLAFFLTFVFQRAIENLDGWSFGHTFETLSGICLLIFGGLGLLIPSIIMRKGKRDKQ
>NC_015571.1|WP_005875129.1|669363_670023_-|ABC-transporter-ATP-binding-protein
MIDIKGIHKTYPGAQPLHVLKGIDLHIAKGEMVSIMGASGSGKSTLLNILGVLDTYDEGEYRLHGELIRNLSENRAAEIRGRLIGFVFQSFNLISFKNAVENVALPLYYQGMSRRKRNEMAMEYLRRVGLEDWADHLPNELSGGQKQRVAIARALAAKPQVILADEPTGALDSVTTVEVMELLRSVNRDGITMVIVTHEQSVADSTDRIIHIKDGIIGA
>NC_015571.1|WP_012457513.1|668064_669339_-|ABC-transporter-permease
MFDLDNLHELGATLRKNMLRTALTGFAVAWGVLLLILLLSAGRGFQHGIRHNVEQFGMGTSAISFSTWRTGKEYGGYPKDRYIELTPADCDYLVKLNPDLIEGAAYYTNQWSYDVQYEDRTHSTPTKAVSGEYGNMVKTHLIEGRFLSTSDDAMKRKVIVLCEQTADVLFGESISPIGKYVNLSQIPFLVVGVCKGEQGQFSPNYIPFATYSGVFAKGFSLDCTLFMNCPSVRTEEDVERLKVLLNRQLAFRKGYDPTDMEVPYVDAPVTDMKMMDKIFNGMDVFLWIIGLSTLVIGIIGVANIMQVTVNERQREIGIRKALGAKPRAIINMILTEAVVVTLFSGLIGLVAGVGLMEFVSHWVQTTGVGSRQVEGITLTLFRDPSIDLSTALLALIVMVVSGAIAGYQPARKAVRIPAVEAMRN
>NC_015571.1|WP_013815550.1|666779_668042_-|ABC-transporter-permease
MRFFDRDRWIEIWHTIYSNRRRSLATAFGVFWGIFMLVVLTSVGAGFSNGILREVSGIASNSAFYWTNLTSKPYMGFRSGRNWSMTSGDIRTVRSQVPEVEFISPIMWGARSNKNVVFGDKSETYSIVGAEPDYFEISRVNILQGRMLNAVDDKLRRKVCMIGKEVKEKLFGTTDPIGQVLRVNGLYYRVIGVLEAKSNNVTIGSSPKRSVYLPYSVLQQISNSGNRVENFAVSAYPSADMKQMFKKIETIIRSRNQIAPDDDKALSKFDISTQFQLMNMIFTGINLLVWIVGIGTLLTGIVGVSNIMLVTVRERTREIGVRRALGAKPRTIIGQILSESLLLTTLAGLLGLIFGVGLMSVVDMAFSQSSSGNFPFYNPLIPFGTALLSLFIIIAGGILGGLLPAYRAIQIKAIDAIRDE
>NC_015571.1|WP_005874254.1|679418_679886_+|HU-family-DNA-binding-protein
MLNLSVKSRLMKIGKHKDKTMYYAQVDKPRVIEYEDVIKDIAEMSSLTTGDVRNAIDRLAYYLQRELTEGNTVRLGQIGTFRVSVPSKYVETEKEVNASILKKPRIRFYINNTLSAVADNIRLAVYRNGQKVDDTTSPSTPSEGGGEQTGGSGGL
>NC_015571.1|WP_021664877.1|679947_680394_+|hypothetical-protein
MKNIILSIMLILSICGVSAQSFDNFMEQRGGEVIARMAHPMNTYESCSYQTRGNSILIKIEYKKCTTELKFYAIGDIFYNLEVLSDTDFYPPFRAVQNIKSILYTMMENEFPETIVAIEDKIGTKIREMDGKQLACMAFTLAWLNYKY
>NC_015571.1|WP_021662723.1|680434_680854_+|hypothetical-protein
MLGAEIIIYLLFCGAFVSQLAKLSIETFEKFMEKDLKEPLKHPTDAKVFREYRENEILWGRKSKFSFFYLCFMPFVAIFILIVIILEIKDPSESFTSIVIPLNIIAIIISRMIIRKNKKFLKQVLDILGTYPNREKTDS
>NC_015571.1|WP_013815558.1|681024_681696_-|M15-family-metallopeptidase
MYRLFVGIAVAMALNTMLCAQTFSEEDFRIRGYVDIHSLDTTIRLALIYSTTDNFVGEDMYGDFDKAYFEKGFAERIRQAQRLLRKEYPDYSLLIYDASRPISIQRRMYTLVKGTSKAVYVANGNRGGKHNYGVAVDLTIVDRDGKPLDMGTPVDHFGRAAHVGQEERLATDGLISREVVRNRRLLRRIMKSVGLVPYRREWWHYELPESMSHTRSHYRLLDF
>NC_015571.1|WP_013815559.1|681727_682951_-|HAD-IIB-family-hydrolase
MKYKIIVIDVFNTLLNNKYELTEENRNALLYIQKELGIRVVLTSGRTVAALKPLAEELNLREYSGYLIPYHGGQIVNCRSGKVIASHRMATSFVEVLDARARAEGVTLLAFGKDSIFSTDPHDPLAVKESDICGQPLVSKHPRSSEVIKCSFVGEAEKIAELEVVMRRDYGDKLNVFRSSETLLECLPSEVQKIKAISDLLDKLDLSREELVSVGDSYCDVEMIQLAGLGVAVANAREAVKACADYITTSNEENGVAHLVDKYIRHEYEAVPFSVEDVNSIVPGTLMESLGIRCTKIARGYVEATMPVDIRTRQPMGILHGGASLAFAETLAGFGSVALCNPGEIQVGLQVSGNHVSSALEGDVLRGEASIMHQGRSTHVWSINIYSTKSGKLICTCRVLNSILKQR
>NC_015571.1|WP_013815560.1|682975_684757_-|hypothetical-protein
MNSIMKYQLYTAVIMALSVSSVCGQTPRNTETKRPDTLRRELTIVNDQTVEMEHADPLPAAYKTIEPRLKPFRPEYNKRTFGFVPEVSSSGRNNLPNILPTEGHMKHRGYLNIGIGHTLNQRMDAGYRLIDAEQERLNLFLSYRGMKSAFNTGDFDGDRKDRRMMAGVDYEQRRPSFVLAAGLYYSNHYFNHYGRGATTNVGSIPQLSTPVTPQMDNGTHNVRVYLGAKNDVIDARIDYRFFRSIPYLGTDPMKALTEHTPELNVTMSNELSDDIKLGVEVRTGGLFFAKNSEMIQTGVLSETDRNLYYVEGAPTIGFVGDSDNMQWNIQAGVGISSHFGAKGRLFFWPKLDASLSIFPSWRVYAKAFGGVIRNGLADVMQEEMPYLMPNTIVLPSRNALTAQLGVKGNIADVVRMEVYGDFSKLTGVPFYTPTLPLYNPSDLYQYNVSFLPLYADGSRWRAGGKLEYSYRDMLRFLVDASYGKWNLDGGLVASMQPDLILKAEVGVHPIAPLDVRLRYTQLNGRYRYSFGSAGSEALGIGNVHLLSADVSYKLKKNLSLYLKIDNMLAETTELIGYYPMQPFHCFAGFSWTF
>NC_015571.1|WP_013815561.1|684792_687780_-|tetratricopeptide-repeat-protein
MKKLILSALVLGGAMTFTAQAQNKAAEPAEEFFLEGRAMFIRQNYVGALDQFRLYRLHGGQEHALEVDYYSIIADYLLGADHDYVLSAVGNFLDNFPESIDKSRVRLLTGELMIRHEQYLRANTIFSDIDDRTLNDEDLAAYLLYYAYVRMQLSESNALAEQMLLKASESRGELGGRACLLLAAIQIEDGRIDEAEQTLSRLKNRPQFADEADAYIAEIQLLRGDYREAAEIADRLLSRNSPMRQRPQLLRVAGNAYYRLGDSNKTIDYLSDYSEKVGDRIAPADAYALGVIYYKQGLMREALRPLAAATTDAGSLGAESALYLGQAQLAEGMTSEALMAFEKAATQDVNRPVREVGMYNMAMLMRSTGQSSFGQSVRIAENFLNEFPRSSHREQMAAILVESYFTGKDYNSSLRSIQKIAQPTASILAAKQFVLNRMAEQKEAAGYDSEALSFVSSSISMGNKGEYFPEAYFLRGNLRYRAGDFPAATADYRAYISAAGDRDAANLPLGYYRLGYSLFNAERYDMALEAFKEYVSRSGIAPNLAADAYARIGDCRYMKRDFHGAREAYSMAYRVYPSGGDYALLRRARLEGLAKQYADQIQTLDKLIREFPDSRHLTAALYEKGCGAVLSGKHNVAEEAFNAVVKRSPDSREARQSSLQLGLLYYNTGRTKEAIRTYQRIIDRYPRSEETTVALSGLRSIYLEEDRIDEYSAYVRGLKDKVSIAPSETEQLGFLSAERKYRRRQPDARRDLEAYLERYPQGSDRHKAELYLADLDYQAGNADAAYNRYSRLVNSPGLPEDYKIDARLRLGRMQYERKEYKAALQSFQSVLDTDGAEAVRDQAVQGVTESAYADKDYRRVIDVIAGLKNQAALPHTLRLYRAKSYQALKMNREAIADYELLAEDFSTATGAEAVVMQAQLEMEAKRLSKAKSILEKFIAKSTPQQYWLARGFILLSDIYKKEGDTFTARQYLESLEKNYPNHEDDIHEQIAQRLE
>NC_015571.1|WP_013815562.1|688037_690278_-|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MTIHDNTLFSADERSRFLSSYASLIRTLAPDRQIVKKVRSLLSRFTELGCFDRDKNGMHGLLRNMEVARIASCEIGLGIEAIGALLFYRPAMKGLMRPEEIAELMGEDVARLIDLLLKTSEIYMRNTAINTANFEHFLLSIAEDIRVVLLIIADRSYLLRQAKDMVCAEERTALAAEVSYLYAPLAHRLGLYAIKSEMEDLCLKYTDRQTFDFIKRKLGETKRSRDAYIEAFIAPLRRRLDEALPNIPYEMKGRTKSINSIRNKLRQQGIEFESIYDLFAIRIILDVPVKDEKAACWHVYSIITDMYQSNPQRMKDWISIPKSNGYESLHVTVMGPQNRWVEVQIRSRRMDEVAERGLAAHWKYKGIKSESGLDEFLTSVRETLEARDHSSDDSAETVKNFKMNLFTDEIYAFTPTGELIKLPQGASVLDFAFAIHSRIGCQAVGANVNGKNVPLKHKLENGDSVSIITSAQQTPKKDWLSYVVSSKARNKIKQQLRLQMESSIGVVKELLNRRLKNRKLPFEEAVFTRVVRRKGFKHLTDFYMEIAADRLDVQEVLELYSHELEEEQRRDAGSGAARRSADTFVAHPPKEEEIVKGGKSDVLVIDNNMTGVEYSFGKCCNPIYGDSVFGFVSNSGIKIHRTDCPNAPDMFSRYGYRIIEARWSGKGSTGYEATLHVIGQDNLAIVTNITSVINKEPGVSLRAYSINSKDNLFEGVFTVEVPDTSTLSILLRKIRATHGVKSAERH
>NC_015571.1|WP_013815563.1|690345_691767_-|cardiolipin-synthase
MIALLIIVYMLMTAAVSAVIISENRNPLKATSWILVVSFVPVLGLIVYIFFGQDQRRRRIVSRRIYKRIMLKPHYLSIPEAQLEAMNNIQLNPIMKLINNNSDSPVMLSSPPDIFTAGKDMFDCFFRDIEAARHHVHIQFYVIEDDHLGSRLSDLLIRKVQEGVKVRVIFDHVGSWATGRGYWKRLRRAGVEAYPFMPVFFPILSSRVNYRNHRKVAVIDGNIGYLGGMNVADRYYSGNRLGLWRDTHFRMMGNVVAGLQSSFLLDWYVVSRRVINLSGYYPDLPIPVSDEGVKIQLVRSGPVGQWRTIEQATIYCIERACEHVYIETPYFLPTEGLNNALITAALAGIDVHLLVPKRSDARLPQVAAFSYVEDLLQAGVHVHLYTNGFLHSKLIMVDSQVASIGSTNMDFRSLENNFEFNGIIYDEPTVRRLEAIFFEDLLQSEPLDLKRWRKRSRIKKFSESFVRLFSPLL
>NC_015571.1|WP_148271470.1|691999_692176_+|DUF1661-domain-containing-protein
MAREQKNSRAATKKFSRRFSGKHAPQSERFRPENFILPLFDNYPFPSIRETAGLKGGK

Crispr_ID: NC_015571_9

• CRISPR_ID: NC_015571_9
• CRISPR_location: 786761-786869
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015571_9

Consensus_repeat	Method
GCCATTGCTTTCATGGCAGCGATTTGAGCCGAGTCGGGGC	CRISPRCasFinder

spacers of NC_015571_9

>9.1|786801|29|NC_015571|CRISPRCasFinder
TCTTCCCTCCATTTGCTTTCATCTTTGCC

CRISPR arrays and Neighbor proteins around NC_015571_9

CRISPR arrays

The CRISPR arrays of NC_015571_9

>merge|NC_015571|9|786761-786869|CRISPRCasFinder
GCCATTGCTTTCATGGCAGCGATTTGAGCCGAGTCGGGGCTCTTCCCTCCATTTGCTTTCATCTTTGCCGCCATTGCTTTCATGGCAGCGATTTGAGCTGAGTCGGGGC

>NC_015571|9|9|786761-786869|CRISPRCasFinder
GCCATTGCTTTCATGGCAGCGATTTGAGCCGAGTCGGGGC	TCTTCCCTCCATTTGCTTTCATCTTTGCC
GCCATTGCTTTCATGGCAGCGATTTGAGCTGAGTCGGGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_173362816.1|792821_795344_-|C10-family-peptidase	unknown	unknown	gnl|CDD|366737
NC_015571.1|WP_013815635.1|796825_797596_-|peroxide-stress-protein-YaaA	unknown	unknown	gnl|CDD|234999
NC_015571.1|WP_012457596.1|789366_791307_-|TonB-dependent-receptor	unknown	unknown	gnl|CDD|238657
NC_015571.1|WP_004584094.1|777808_778678_+|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl|CDD|130274
NC_015571.1|WP_004585363.1|797680_798100_-|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|238329
NC_015571.1|WP_004585365.1|799412_799856_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl|CDD|376515
NC_015571.1|WP_013815625.1|780143_781208_+|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl|CDD|187557
NC_015571.1|WP_013815630.1|784237_784924_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_005874580.1|779279_780137_+|dTDP-4-dehydrorhamnose-reductase	unknown	unknown	gnl|CDD|367904
NC_015571.1|WP_077492526.1|795730_795877_-|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_005874565.1|781282_782371_+|glycine-cleavage-system-aminomethyltransferase-GcvT	unknown	unknown	gnl|CDD|234742
NC_015571.1|WP_004585349.1|783271_783598_-|DUF2149-domain-containing-protein	unknown	unknown	gnl|CDD|378306
NC_015571.1|WP_004585361.1|796111_796687_-|superoxide-dismutase	unknown	unknown	gnl|CDD|223678
NC_015571.1|WP_004585355.1|791321_791972_-|HmuY-family-protein	unknown	unknown	gnl|CDD|379448
NC_015571.1|WP_043890159.1|798155_799400_-|U32-family-peptidase	unknown	unknown	gnl|CDD|223896
NC_015571.1|WP_013815624.1|775738_777694_+|alkaline-phosphatase-family-protein	unknown	unknown	gnl|CDD|293739
NC_015571.1|WP_004584095.1|778692_779283_+|dTDP-4-dehydrorhamnose-3,5-epimerase	unknown	unknown	gnl|CDD|376414
NC_015571.1|WP_013815629.1|783603_784182_-|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl|CDD|223881
NC_015571.1|WP_013815623.1|774415_775654_+|3-deoxy-D-manno-octulosonic-acid-transferase	unknown	unknown	gnl|CDD|224436
NC_015571.1|WP_013815637.1|799858_800911_-|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl|CDD|234666

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_173362816.1|792821_795344_-|C10-family-peptidase	gnl|CDD|366737	pfam01640, Peptidase_C10, Peptidase C10 family. This family represents just the active peptide part of these proteins. Residues 1-120 are not part of the model as they form the pro-peptide, which before cleavage blocks the active site from the substrate. The catalytic residues of histidine and cysteine are brought close together at the active site by the folding of the active peptide.	5.95641e-69
NC_015571.1|WP_012457596.1|789366_791307_-|TonB-dependent-receptor	gnl|CDD|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.36309e-97
NC_015571.1|WP_004584094.1|777808_778678_+|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl|CDD|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	2.00296e-179
NC_015571.1|WP_004585363.1|797680_798100_-|acyl-CoA-thioesterase	gnl|CDD|238329	cd00586, 4HBT, 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).	5.19564e-26
NC_015571.1|WP_004585365.1|799412_799856_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl|CDD|376515	pfam01288, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK).	2.45438e-50
NC_015571.1|WP_013815625.1|780143_781208_+|dTDP-glucose-4,6-dehydratase	gnl|CDD|187557	cd05246, dTDP_GD_SDR_e, dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs. This subgroup contains dTDP-D-glucose 4,6-dehydratase and related proteins, members of the extended-SDR family, with the characteristic Rossmann fold core region, active site tetrad and NAD(P)-binding motif. dTDP-D-glucose 4,6-dehydratase is closely related to other sugar epimerases of the SDR family. dTDP-D-dlucose 4,6,-dehydratase catalyzes the second of four steps in the dTDP-L-rhamnose pathway (the dehydration of dTDP-D-glucose to dTDP-4-keto-6-deoxy-D-glucose) in the synthesis of L-rhamnose, a cell wall component of some pathogenic bacteria. In many gram negative bacteria, L-rhamnose is an important constituent of lipopoylsaccharide O-antigen. The larger N-terminal portion of dTDP-D-Glucose 4,6-dehydratase forms a Rossmann fold NAD-binding domain, while the C-terminus binds the sugar substrate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NC_015571.1|WP_013815635.1|796825_797596_-|peroxide-stress-protein-YaaA	gnl|CDD|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	2.13399e-84
NC_015571.1|WP_005874580.1|779279_780137_+|dTDP-4-dehydrorhamnose-reductase	gnl|CDD|367904	pfam04321, RmlD_sub_bind, RmlD substrate binding domain. L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesized by four different enzymes the final one of which is RmlD. The RmlD substrate binding domain is responsible for binding a sugar nucleotide.	1.64758e-126
NC_015571.1|WP_077492526.1|795730_795877_-|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	5.91792e-06
NC_015571.1|WP_005874565.1|781282_782371_+|glycine-cleavage-system-aminomethyltransferase-GcvT	gnl|CDD|234742	PRK00389, gcvT, glycine cleavage system aminomethyltransferase GcvT.	0
NC_015571.1|WP_004585349.1|783271_783598_-|DUF2149-domain-containing-protein	gnl|CDD|378306	pfam09919, DUF2149, Uncharacterized conserved protein (DUF2149). This domain, found in various hypothetical prokaryotic proteins, has no known function.	1.052e-40
NC_015571.1|WP_004585361.1|796111_796687_-|superoxide-dismutase	gnl|CDD|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	2.89256e-85
NC_015571.1|WP_004585355.1|791321_791972_-|HmuY-family-protein	gnl|CDD|379448	pfam14064, HmuY, HmuY protein. HmuY is a novel heme-binding protein that recruits heme from host carriers and delivers it to its cognate outer-membrane transporter, the TonB-dependent receptor HmuR. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 278 amino acids in length.	5.79537e-30
NC_015571.1|WP_043890159.1|798155_799400_-|U32-family-peptidase	gnl|CDD|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	2.12222e-87
NC_015571.1|WP_013815624.1|775738_777694_+|alkaline-phosphatase-family-protein	gnl|CDD|293739	cd16015, LTA_synthase, Lipoteichoic acid synthase like. Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.	8.79233e-65
NC_015571.1|WP_004584095.1|778692_779283_+|dTDP-4-dehydrorhamnose-3,5-epimerase	gnl|CDD|376414	pfam00908, dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. This family catalyze the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	1.23435e-101
NC_015571.1|WP_013815629.1|783603_784182_-|MotA/TolQ/ExbB-proton-channel-family-protein	gnl|CDD|223881	COG0811, TolQ, Biopolymer transport proteins [Intracellular trafficking and secretion].	2.58967e-11
NC_015571.1|WP_013815623.1|774415_775654_+|3-deoxy-D-manno-octulosonic-acid-transferase	gnl|CDD|224436	COG1519, KdtA, 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane].	3.73381e-62
NC_015571.1|WP_013815637.1|799858_800911_-|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl|CDD|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0

Protein sequences

>NC_015571.1|WP_013815630.1|784237_784924_-|hypothetical-protein
MREVLLTIALLATLKYLFEEGVHSSLLVRCLHAAVYAAFIALVHGLTQHVSRMEVETLLYSPEALRNVSLAVMVDLLYVVYICTHRPSSFRLYRTWVRHLPPLLFFPTLFYLRLSLFYVLPGYSFVGVSIVMALIVAALSITAPYLWRALGLKREALREPLVLLSLCTFVFVIAAGVLHPDSAVRTVGITTDWWQALYLFLIVLAGASIGYFAPRLWAIIRRKNNRKK
>NC_015571.1|WP_013815629.1|783603_784182_-|MotA/TolQ/ExbB-proton-channel-family-protein
MNFLSNVMFWVSNGLLVPVVAGLIYLFIKSLLLLGTLFGTWQSYRRRQETFARIIENKAGLDTEALRAEAAKRPHAPFENVLAEVLDADSARRNLLIGRYELSREQRLSSAKVLTKFGPILGLMGTLIPMGPALVGLSTGDIGQMAYNMQVAFATTVIGMFASAVGYIALHIVRTYNRNDLVWLDYINEKLS
>NC_015571.1|WP_004585349.1|783271_783598_-|DUF2149-domain-containing-protein
MSRRRFHEEDTDPSSLVSNLFDVAMVFAVALMVALVTKFNMTEVFSKEDYTIVKNPGKDNMEILIKKGDKVEKYTPSDESSDGAGSKGKRVGVAYQLESGEIIYVPED
>NC_015571.1|WP_005874565.1|781282_782371_+|glycine-cleavage-system-aminomethyltransferase-GcvT
MKTTPFTDVHIALGAKMHEFAGYNMPIEYGGIIDEHMNVVNNVGVFDVSHMGEFWVKGPNALRFLQKVSSNDASKLAVGQVQYCCFPNNDGGIVDDFLLYRYEEEKYMMVPNAANIAKDWAWCRQQNTMGAILENASDNIAQLAVQGPKATEVMQRLTDIDLNEITYYTFKVGSFAGCPDVIISATGYTGAGGFELYFYPQYAQKIWDALFEAGKPEGIKPAGLGARDTLRLEMGFCLYGNDICDTTSPIEAGLGWITKFTDDKMDMPSRKIMEEQKAGGLKRKLVAFELKDKGIPRQHYEIANAEGQIIGEVTSGTMSPCLKKGIGMGYVATEFSKVGTELGIMVRGRQLKAEIVKPPFRK
>NC_015571.1|WP_013815625.1|780143_781208_+|dTDP-glucose-4,6-dehydratase
MNFRRHILITGGAGFIGSHVVRLMVNGYPDYEIINLDTLTYAGNLANLKDIESKPNYRFVKADICNANTLKKVFAHYAIDGVIHLAAESHVDRSIKDPLAFARTNVMGTLTLLQTAKEAWHGEYEGKRFYHISTDEVYGALAFDGTLFTEETKYDPHSPYSASKASSDHFVRAYHDTFGLPTVISNCSNNYGPYQFPEKLIPLFINNIRHNKPLPVYGKGENVRDWLYVEDHARAIDLIFHRGKNGDTYNIGGFNEWKNIDLIKVMIRVVDRLLGREEGSSEKLITYVADRAGHDLRYAIDSTKLKNELGWEPSLQFEEGIEKTVRWYLHNQDWLDRVTSGDYLRYYDEMYSER
>NC_015571.1|WP_005874580.1|779279_780137_+|dTDP-4-dehydrorhamnose-reductase
MNRILVTGADGQLGSELRLLASADSRFVFTDLAELDIRDKDAVLRFMEEYSIGIIINCAAYTAVDKAEDDEASAEKVNHQAAAHLAAAAAKYDALLIHISTDYVFDGTANIPYREDIPTAPLGAYGRTKLKGEQAVLAADCRYMILRTSWLYSSFGNNFVKTMLRLTAERDTLNVVFDQVGTPTYAADLAAFIHRLAIGQLPVKTGLYHFSNEGVCSWFDFAVAIARMSGHTACRISPCHSDEYPTRVRRPHYSVLDKTLIKNTFDISIPHWQDSLAACLNLLKH
>NC_015571.1|WP_004584095.1|778692_779283_+|dTDP-4-dehydrorhamnose-3,5-epimerase
MNFIPTEIPEVVILEPRLFRDDRGYFFESFSRQEIETGIRPINFVQDNESASRYGVLRGLHFQKPPHAQSKLVRVVRGCVIDYAVDIRFGSPTFGKYVAVELSDTNFRQLFIPRGFAHGFVVLSDEVVFQYKCDNYYAPQSEGAIAWNDSNLDIDWKIPAEDIILSAKDQANPSWTELISSEDFRNLFPYNQDLYE
>NC_015571.1|WP_004584094.1|777808_778678_+|glucose-1-phosphate-thymidylyltransferase-RfbA
MKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPLSTLMLAGIRDVLIISTPQDLSMFQRLLGDGRDLGVRLEYAEQPSPDGLAQAFIIGREFVGDDCACLVLGDNIFYGHGFSQMLRSAVADAEKGMATIFGYYVNDPERYGVAEVDATGKVISLEEKPEKPKSNYAVVGLYFYPNDVLDVAADVKPSARGELEITSVNQEFMLRKQLRLQQLGRGFAWLDTGTHESLTDASVFVSVIEKRQGLKIACLEEIAYNNGWLTKEDLARVAEPMKQNQYGKYLLGLIK
>NC_015571.1|WP_013815624.1|775738_777694_+|alkaline-phosphatase-family-protein
MNICKRTIRTNSWWAFAYRMALAYFFFGIARGLFYLFNYRFFADMTAEQVWRAWMGGLRFDTASVLYLNALFILLSFLPFRFRTKRSYRILTDWTFFVPNALGLAAGLADCIYYPYTLKRTSSTVFSEFSHEGGGLIWHLLLNYWYMSLLAIVLVAAMVWLYHRVKPVRTYAEAKDSLHYYTVHVVALVAAIAFIVWGIRGGSFAKSWRPMTMSYANLSVDKVEHRALVLNTPYSIIRTIGKQGLEEKRFYASEKELEQVFNPIHHLATDTTARFSQLRGRNVMVIIIESFARQYVGRLNQDIPDYKGYTPCFDSISQKGYLFEQAFANGRKSIDAMPSILSSLPSLRSHFITSHYSGNEIEGLGTALGRIGYQSIFLHGAPNGSMGFDAFVKQAGYKRYFGKTEYANDEDFDGVWGIWDEPFLLHAVDELSRMKQPFVGTLFTLSSHEPFHIPSHREGLFPNEGEPLVQCIGYTDHALGEFFRKASRQTWFENTLFVITADHASGDLRPEYRSAVGRYAIPILFYAPGSDLIGFDRTTTVQQADILPTVLSLLGYSAPVLAFGNNMFSRQAPHFAVTDYDGTLQLLEDGLVLQHDGNHPLALYDYLNDKELRTNLIKTQTARADSMTCRIEAVIQSFNHRMNTNRLVADK
>NC_015571.1|WP_013815623.1|774415_775654_+|3-deoxy-D-manno-octulosonic-acid-transferase
MRFLFSLIGLVYSSLIKLAVPFNPKARMMVRGRWKVWRQLREGIVPGGRYIWFHAASLGEFEQGRPMIERIRSEYPDYRIVLTFFSPSGYEVRKNYEGADVIVYLPADRLSRVRKFLDLVKPEMAIFIKYDFWPCFLTELERSQIPTYLVSSIFRPSQLFFHWYGGAYKRLLHCFTHIFVQDEASRLLLEKHGIDHVSVAGDTRFDRVISVYEARKSLPLIERFAASVPEDGLVIVGGSSWPPDEEILVRYFNRNPKIKLILAPHEIDKEHLLQIISHIRRPFIRLSEATESDIARQDCLIVDSFGLLSSIYRYGQVAFIGGGFGKGIHNTPEAAVYGIPVIFGPRYEKFKEARELIDVGGGFSVSSAEEFGNLIKRIQTDKAYRDAASHAAADYIRSNAGATEYIVHRIMK
>NC_015571.1|WP_012457596.1|789366_791307_-|TonB-dependent-receptor
MKSVVTKQALIGLLFFSISIYSHAANPPAQPTDTIVSGNIALEDIVVTGSRTARLLKDVPVPTKVFKAKDIKAIAPSSFIDVLQYILPGIEFTKHGSRDQLNAQGFDESSILFLVDGELISTGSTSGIDFERINPDDIERIEVLRGASSALYGSNAIGGVINIITRTAKDPFRVSASARYDSRDGQKYDVAAGVKRGIFTSQSGVQYRADKSYILADQFEQELNVAGNTTWNINQKFTISPTENLSFNLTGLVNLRKQHWTDKIDFLYNSYDVKAGANWRISETSDLDISYHYDKYSRDTCLIKTENQKKLPIFDEDMHHLRAQYNLNLAEVHLLNVGLEYIHDNVASPRLSSPNDPGEKSVNNKILYGQYIYKVTPKLVLSYGGRLDKHSGFGLYYTSRLSAMYKCSHVTNRLSYAEGYRAPSLQEMYFFFNHGAFFIYGNPDLKPEKSRMLSYSAEAHWNKLTLMGNVFFNHVRNRIDFTYKGTDLIYTNVSKEMRIFGFEGQANVVLPYGFGFRASYSYTYDRWKATDKAGTEMKLSNTRPHAATATLSYGHNFSKNYRLASNFSTRFLSDLKTGRMNSNELFEEITYPGYTICRLDIENHFYRNYTLHIGAENLFDYKPKALAFNSPTSPGRIIYGLVRITF
>NC_015571.1|WP_004585355.1|791321_791972_-|HmuY-family-protein
MKKIIFSALCALPLIVSLTSCGKKKDEPNQPSTPEAVTKTVTIDASKYETWQYFSFSKGEVVNVTDYKNDLNWDMALHRYDVRLNCGESGKGKGGAVFSGKTEMDQATTVPTDGYTVDVLGRITVKYEMGPDGHQMEYEEQGFSEVITGKKNAQGFASGGWLEFSHGPAGPTYKLSKRVFFVRGADGNIAKVQFTDYQDAELKKGVITFTYTYPVK
>NC_015571.1|WP_173362816.1|792821_795344_-|C10-family-peptidase
MKRIFYTLGLLLLCLPMLQAGPVTRSKAEQTAKNFFAKRQPTLSSSTASLRMDFVYKTTEREEALFFVFNRGEKDGFLLVAADDRFPEVIGYAFKGHFDAARIPDNLRGWLKGYEREMLAVMDGKAEPIDPIREAKPTRDLPSSIAPILETGEHASDPILWDQDYPFNTLHPLLPSGQQAYTGCVATAMGQIMRHYKWPEKASGGYDYYDDMTGTHTHYSGTFGETYNWSKMPGNISVGISPEEVKALSTFMRDVSFSVNMQFADFGSGTFSIFVERALRETFHYKKSLRYIHRSLLPGKEWKDMIRKELAENRPVYYAGADGSMGHAFVCDGYEPDGTFHFNWGWGGMSNGNFYLNLLNPGSLGTGAGDGGYSTDQEVVIGIEPASNEAPGIVPDPTITLYGLQHNMSDEALDLSVKIKNYSTYAGDVKLAYRLTLPNGTETTNPAVTVPIVWEDIIGESTGNITIPCSQFAEGKNTISILYRTDGMADWKELKHILMGLVNKIEVTMPAGDVAYSVADARIVLKDGSLSHNLKAYSDCKLSATVYNPGTEEFRSRVTFALRNTEGRLYFLGRHLVELHPGDEDGEKVSLTITGLKARAGQYMLVCTGDMESLMEDASWIELASIEVAEHTSTHSSLLVASNPQIDLLTVHRANPETLPTFSITNEGGATFSGKIEIVAIKAFSETFFQAKEEHMSLAQGETKVLSPELTASSSLYTNAELFPDGIYYIVIREQGFWDPIDLFGDYYYRIRLITDLSSSDIAGKDVSTIVLYPNPAHDYVHVAIPPTYAGSTLRLFDIQGRMQLSTKIESADMRLDVERLPKGTYIVVVEDMVGKLFIR
>NC_015571.1|WP_077492526.1|795730_795877_-|DUF1661-domain-containing-protein
MLLLKTRFVNFFILAWEAKNSHATTKKISRHFFREYAPQSELFRFVFF
>NC_015571.1|WP_004585361.1|796111_796687_-|superoxide-dismutase
MTHELISLPYAVDALAPVISKETVEFHHGKHLKTYVDNLNKLIIGTEFENADLNTIVQKSEGGIFNNAGQTLNHNLYFTQFRPGKGGAPKGKLGEAIDKQFGSFEKFKEEFNTAGTTLFGSGWVWLASDANGKLSIEKEPNAGNPVRKGLNPLLGFDVWEHAYYLTYQNRRADHLKDLWSIVDWDIVESRY
>NC_015571.1|WP_013815635.1|796825_797596_-|peroxide-stress-protein-YaaA
MLILLSCTKTIGIPKRLPSHLTTTSPIFDEQTTKIALAASSCDIEELSRLLRINRKLAEENHRRWQHFFEDDSPTAPAALAYTGMVFKKLAPANFNADDWLYASEHLLITSFLYGLLRPSDMIRPYRMEGFAHLGAPVEDEVFNFWRPYLTDFLIEKVREKGGELCFLASEEMKMLFDWKRVEQAVRVVTPLFKVPQPDGGLKQIVIYTKMARGLMTAHLLTRRCRHVEEMQLFSPEGFIFRPELSDESNYLFVME
>NC_015571.1|WP_004585363.1|797680_798100_-|acyl-CoA-thioesterase
MKEKEYLFSLDMKVRDYECDLQGVVNNSNYQRYMEHTRHEFWESLGDNFGQMHEKGLDAFVYKVTITFKQSLRSGDRFRSCLTCHKKGPKLIFMQDIIREDGVMAACGEVEVVAVQDGVLTRGEYFDVLMKDILSKTTK
>NC_015571.1|WP_043890159.1|798155_799400_-|U32-family-peptidase
MNVNDFEIMAPVGSYESLMAAIKAGADSVYFGIEGLNMRARSANNFTTEDLYKIAEICRNKGVKSYLTVNTVIYDEDIALMRSVIDAAQKAQISAIIASDVAAMTYANEIGVEVHLSTQLNISNAEALRFYSRFADVVVLARELNMDQVRTIHETIVRDNICGPKGHPVRIEMFAHGALCMAVSGKCYLSLHEHNSSANRGACAQICRRGYTVKDKDSGLELDIENQYIMSPKDLKTIHFINKMMDAGVRVFKIEGRARGPEYVYTVCRCYKEAIEAYCNGTYDEESIGRWDEQLATVFNRGFWDGYYLGQRLGEWTHRYGSGATRQKIYVGKGIKYFSRLGVAEFEIESGELHIGDEIVITGPTTGVIIQKVEEIRYELQTVEKATKGQRISIPVKEKVRPSDKLYRFDKREE
>NC_015571.1|WP_004585365.1|799412_799856_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MAIVYLSLGSNLGDRHSLLSAALEMLQTRVGRLLTLSRFYETEPWGFESPHPFLNAVVALRSELKPQDILHITQAIERELGRTQKSNGGVYHDRPIDIDILLHSVYPKVQSPELELPHPQMWQRDFVRMPLSDVAPWLHPEAPTPNL
>NC_015571.1|WP_013815637.1|799858_800911_-|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MKLSKFKFNLPEELIALEPTKFRDESRMMVVHRRTGEIEHRVFKDILEYFDKGDTFVFNNTRVFPARLYGNKEKTGAQIEVFLLRELNERLKLWDVLVDPARKIRIGNKLYFGNDEELVAEVIDNTTSRGRTLRFLYDGSHDEFKELLFQLGQTPLPKYIDRDVNKEDPERYQSIFAEVEGAVVAPAASLHFSRELMKRLEIKDCHFSYITVHHALGAYRDIDVEDLTKHKMDSEEMYITEESCININRSWDEEKKICAVGTSILRALETAVSTDGHLKPFEGWTNRFIFPPYEFHLPSALVTNFHMPLSTLLMMTAAFGGHEPIMSAYDLAVKEKYRFGAYGDAMLIID

Crispr_ID: NC_015571_10

• CRISPR_ID: NC_015571_10
• CRISPR_location: 1515077-1515311
• CRISPR_type: TypeVI-B2,TypeVI-B1
• Repeat_type: VI-B2
• Spacer_info: 3 spacers
• Cas_protein_info: Csx28,cas13b

Consensus repeat of NC_015571_10

Consensus_repeat	Method
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	CRISPRCasFinder
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	CRT
GTTGGATCTACCCTCTATTCGAAGGGTACACACAACA	PILER-CR

spacers of NC_015571_10

>10.1|1515113|30|NC_015571|CRISPRCasFinder,CRT
GATGTGGCTGTAGATGCACTCTTCCGCAAA
>10.2|1515179|30|NC_015571|CRISPRCasFinder,CRT
GAAGTGGCCAATGTTCGATAGGCTGCTCAG
>10.3|1515245|30|NC_015571|CRISPRCasFinder,CRT
ACTGCCATATTATATAAGTGTGATTATTTT
>10.4|1515180|29|NC_015571|PILER-CR
AAGTGGCCAATGTTCGATAGGCTGCTCAG
>10.5|1515246|29|NC_015571|PILER-CR
CTGCCATATTATATAAGTGTGATTATTTT

CRISPR arrays and Neighbor proteins around NC_015571_10

CRISPR arrays

The CRISPR arrays of NC_015571_10

>merge|NC_015571|10|1515077-1515311|CRISPRCasFinder,CRT,PILER-CR
GTTGGATCTACCCTCTATTCGAAGGGTACACACAACGATGTGGCTGTAGATGCACTCTTCCGCAAAGTTGGATCTACCCTCTATTCGAAGGGTACACACAACGAAGTGGCCAATGTTCGATAGGCTGCTCAGGTTGGATCTACCCTCTATTCGAAGGGTACACACAACACTGCCATATTATATAAGTGTGATTATTTTGTTGGATCTACCCTCTATTCGAAGGGTACACACAACA

>NC_015571|10|10|1515077-1515310|CRISPRCasFinder
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	GATGTGGCTGTAGATGCACTCTTCCGCAAA
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	GAAGTGGCCAATGTTCGATAGGCTGCTCAG
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	ACTGCCATATTATATAAGTGTGATTATTTT
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC

>NC_015571|10|5|1515077-1515310|CRT
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	GATGTGGCTGTAGATGCACTCTTCCGCAAA
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	GAAGTGGCCAATGTTCGATAGGCTGCTCAG
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC	ACTGCCATATTATATAAGTGTGATTATTTT
GTTGGATCTACCCTCTATTCGAAGGGTACACACAAC

>NC_015571|10|5|1515143-1515311|PILER-CR
GTTGGATCTACCCTCTATTCGAAGGGTACACACAACG	AAGTGGCCAATGTTCGATAGGCTGCTCAG
GTTGGATCTACCCTCTATTCGAAGGGTACACACAACA	CTGCCATATTATATAAGTGTGATTATTTT
GTTGGATCTACCCTCTATTCGAAGGGTACACACAACA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_004584828.1|1518962_1519556_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_013816153.1|1508169_1509129_-|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|133030
NC_015571.1|WP_013816159.1|1520271_1521300_+|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl|CDD|187558
NC_015571.1|WP_043890087.1|1517490_1518960_-|metallophosphoesterase-family-protein	unknown	unknown	gnl|CDD|277318
NC_015571.1|WP_043890086.1|1501881_1502784_-|glutamate-formimidoyltransferase	unknown	unknown	gnl|CDD|226169
NC_015571.1|WP_013816156.1|1514321_1514867_+|hypothetical-protein	Csx28	-	unknown
NC_015571.1|WP_013816161.1|1523438_1524209_+|HAD-IA-family-hydrolase	unknown	unknown	gnl|CDD|223710
NC_015571.1|WP_013816160.1|1521342_1523439_+|ATP-dependent-DNA-helicase-RecG	unknown	unknown	gnl|CDD|236794
NC_015571.1|WP_013816157.1|1516128_1517328_-|methionine-gamma-lyase	unknown	unknown	gnl|CDD|168478
NC_015571.1|WP_004584821.1|1510100_1510670_-|hypothetical-protein	unknown	unknown	unknown
NC_015571.1|WP_004584817.1|1507250_1508159_+|DMT-family-transporter	unknown	unknown	gnl|CDD|273359
NC_015571.1|WP_004584829.1|1519656_1520262_+|YihA-family-ribosome-biogenesis-GTP-binding-protein	unknown	unknown	gnl|CDD|234770
NC_015571.1|WP_012458422.1|1503852_1504371_-|HU-family-DNA-binding-protein	unknown	unknown	gnl|CDD|273496
NC_015571.1|WP_013816154.1|1509181_1510084_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl|CDD|234626
NC_015571.1|WP_013816162.1|1524303_1525761_-|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|380191
NC_015571.1|WP_012458402.1|1527833_1528019_-|DUF1661-domain-containing-protein	unknown	unknown	unknown
NC_015571.1|WP_013816152.1|1505046_1507023_+|transcription-termination-factor-Rho	unknown	unknown	gnl|CDD|236490
NC_015571.1|WP_013816155.1|1510957_1514317_+|hypothetical-protein	cas13b	cas13b_CAS_V-B1	gnl|CDD|380475
NC_015571.1|WP_080580311.1|1526325_1527768_+|exo-alpha-sialidase	unknown	unknown	gnl|CDD|271234
NC_015571.1|WP_012458423.1|1502824_1503820_-|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_015571.1|WP_013816156.1|1514321_1514867_+|hypothetical-protein	Csx28	-	1.5e-95	313.0	1.2
NC_015571.1|WP_013816155.1|1510957_1514317_+|hypothetical-protein	cas13b	cas13b_CAS_V-B1	0	1398.9	19.8

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_013816153.1|1508169_1509129_-|glycosyltransferase-family-2-protein	gnl|CDD|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	4.31474e-97
NC_015571.1|WP_013816159.1|1520271_1521300_+|UDP-glucose-4-epimerase-GalE	gnl|CDD|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NC_015571.1|WP_043890086.1|1501881_1502784_-|glutamate-formimidoyltransferase	gnl|CDD|226169	COG3643, COG3643, Glutamate formiminotransferase [Amino acid transport and metabolism].	1.54603e-150
NC_015571.1|WP_013816161.1|1523438_1524209_+|HAD-IA-family-hydrolase	gnl|CDD|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	6.85412e-38
NC_015571.1|WP_013816160.1|1521342_1523439_+|ATP-dependent-DNA-helicase-RecG	gnl|CDD|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NC_015571.1|WP_013816157.1|1516128_1517328_-|methionine-gamma-lyase	gnl|CDD|168478	PRK06234, PRK06234, methionine gamma-lyase; Provisional.	0
NC_015571.1|WP_004584817.1|1507250_1508159_+|DMT-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.48889e-12
NC_015571.1|WP_004584829.1|1519656_1520262_+|YihA-family-ribosome-biogenesis-GTP-binding-protein	gnl|CDD|234770	PRK00454, engB, GTP-binding protein YsxC; Reviewed.	2.70082e-98
NC_015571.1|WP_012458422.1|1503852_1504371_-|HU-family-DNA-binding-protein	gnl|CDD|273496	TIGR01201, HU_rel, DNA-binding protein, histone-like, putative. This model describes a set of proteins related to but longer than DNA-binding protein HU. Its distinctive domain architecture compared to HU and related histone-like DNA-binding proteins justifies the designation as superfamily. Members include, so far, one from Bacteroides fragilis, a gut bacterium, and ten from Porphyromonas gingivalis, an oral anaerobe. [DNA metabolism, Chromosome-associated proteins].	1.34591e-52
NC_015571.1|WP_013816154.1|1509181_1510084_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl|CDD|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	1.69251e-125
NC_015571.1|WP_013816162.1|1524303_1525761_-|leucine-rich-repeat-domain-containing-protein	gnl|CDD|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	1.77428e-35
NC_015571.1|WP_043890087.1|1517490_1518960_-|metallophosphoesterase-family-protein	gnl|CDD|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.20368e-14
NC_015571.1|WP_013816155.1|1510957_1514317_+|hypothetical-protein	gnl|CDD|380475	cd20477, Cas13b_Pb-like, Class 2 type VI-B CRISPR-associated RNA-guided ribonuclease Cas13b from Prevotella buccae and similar Cas13b proteins. CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins) adaptive immune systems defend microbes against foreign nucleic acids via RNA-guided endonucleases. These systems are divided into two classes: class 1 systems utilize multiple Cas proteins and CRISPR RNA (crRNA) to form an effector complex while class 2 systems employ a large, single effector with crRNA to mediate interference. Class 2 type VI CRISPR-Cas13 systems use a single enzyme to target RNA using a programmable crRNA guide and are divided into four subtypes based on the identity of the Cas13 protein (Cas13a-d). The Cas13 proteins are capable of both pre-crRNA processing and target RNA cleavage, which protect the host from phage attacks. Once bound to a target RNA, their non-specific RNase activity is activated. Cas13b has many distinctive features compared to the other Cas13 proteins, including the lack of significant sequence similarity, disparate crRNA repeat region, and double-sided protospacer flanking sequence (PFS)-dependent target RNA cleavage.	0
NC_015571.1|WP_080580311.1|1526325_1527768_+|exo-alpha-sialidase	gnl|CDD|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	4.09442e-93
NC_015571.1|WP_013816152.1|1505046_1507023_+|transcription-termination-factor-Rho	gnl|CDD|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	0

Protein sequences

>NC_015571.1|WP_013816156.1|1514321_1514867_+|hypothetical-protein
MMTMTICWTPICVQLIKLSGIFIAAYLAYRYAVRKLSLESIENIERCKYQAVLEAHRSFYKLLRFTTDTENADSILVWQKAKGGGAKTYYFRPACIRGFLSELTDEFYKNGNGIFLSKEIISRIFEYRSIVYGLLLSERQNSDERIVMNKPETAERMISIHQELTQTVREAIALKKRTLNF
>NC_015571.1|WP_013816155.1|1510957_1514317_+|hypothetical-protein
MTEQNEKPYNGTYYTLEDKHFWAAFFNLARHNAYITLAHIDRQLAYSKADITNDEDILFFKGQWKNLDNDLERKARLRSLILKHFSFLEGAAYGKKLFESQSSGNKSSKNKELTKKEKEELQANALSLDNLKSILFDFLQKLKDFRNYYSHYRHPESSELPLFDGNMLQRLYNVFDVSVQRVKRDHEHNDKVDPHRHFNHLVRKGKKDRYGNNDNPFFKHHFVDREGTVTEAGLLFFVSLFLEKRDAIWMQKKIRGFKGGTETYQQMTNEVFCRSRISLPKLKLESLRTDDWMLLDMLNELVRCPKSLYDRLREEDRARFRVPVDILSDEEDTDGAEEDPFKNTLVRHQDRFPYFALRYFDLKKVFTSLRFQIDLGTYHFAIYKKNIGEQPEDRHLTRNLYGFGRIQDFAEEHRPEEWKRLVRDLDYFETGDKPYITQTTPHYHIEKGKIGLRFVPEGQHLWPSPEVGATRTGRSKYAQDKRFTAEAFLSAHELMPMMFYYFLLREKYSEEASAERVQGRIKRVIEDVYAVYDAFARDEINTRDELDACLADKGIRRGHLPRQMIGILSQEHKDMEEKIRKKLQEMMADTDHRLDMLDRQTDRKIRIGRKNAGLPKSGVIADWLVRDMMRFQPVAKDTSGKPLNNSKANSTEYRMLQRALALFGGEKERLTPYFRQMNLTGGNNPHPFLHETRWESHTNILSFYRSYLKARKAFLQSIGRSDRVENHRFLLLKEPKTDRQTLVAGWKGEFHLPRGIFTEAVRDCLIEMGLDEVGSYKEVGFMAKAVPLYFERACKDWVQPFYNYPFNVGNSLKPKKGRFLSKEKRAEEWESGKERFRLAKLKKEILEAKEHPYLDFKSWQKFERELRLVKNQDIITWMICGDLMEENKVEGLDTGTLYLKDIRTDVQEQGSLNVLNRVKPMRLPVVVYRADSRGHVHKEQAPLATVYIEERDTKLLKQGNFKSFVKDRRLNGLFSFVDTGALAMEQYPISKLRVEYELAKYQTARVCAFEQTLELEESLLTRCPHLPDKNFRKMLESWSDPLLDKWPDLHRKVRLLIAVRNAFSHNQYPMYDEAVFSSIRKYDPSFPDAIEERMGLNIAHRLSEEVKQAKETVERIIQA
>NC_015571.1|WP_004584821.1|1510100_1510670_-|hypothetical-protein
MVFNFLIVSDEVEDFRREIAIDSEATFLDLQNAILDSVGYSHSELTSFFLCDEDWHKGQEITLMEMDTASDEDSYVMENTRLEEFIEDEHQRLVFEFDLMTERYFFIEVMDIVPGKSLSEPKLLTSEGLPPQQSSLDDLMDPTAIPTKQARGLDLEEDFFGDSEYNEDEIDREGFEGFDEITSDLSDNY
>NC_015571.1|WP_013816154.1|1509181_1510084_-|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
METQDHTLYVLLGPTGVGKTDLSLDIAERLGSPIISADSRQIFRELPIGTAAPTPEQRARVPHLFVGTHSVRDYYSAGMYEVEVLEALKELFRKYRGVLLTGGSMMYIDAVCRGIDDIPDPFPEVREELYARYGAEGLDGILAQLRLLDPDYYAKVDRRNYKRVIHGLEICLSTGRPFSSFHRHEAKERPFRIVKIGLYREREELCKRIDARVLEMMEQGLEEEARAVYPLRHLNALNTVGYKEMFEYFDGSIDQAEAVRRIQRNSRVYARKQMTWFRHDSTIRWFHPEADKGTVLTLVT
>NC_015571.1|WP_013816153.1|1508169_1509129_-|glycosyltransferase-family-2-protein
MDVNTTYTKELSIIVPIYNEERELPELVRRLSAAAASITEDYELIFVNDGSRDGSLELLRSLCKGDDRFFYINLSRNFGHQIAVSAGLDHVRGKATVIIDGDLQDPPELIPELYAKYREGYEVVYAQRKHREGETWFKKATAKGFYRTMRKITSIDMPLDTGDFRLIDRKIVQCLREMPEQNKFLRGQIAWMGFRQTGVQFDRDERKYGQTNYPLRKMLALAIDGITGFSSRPLEWVAQLGAWVSLLSLFVIVYALISHFLLDKTVSGWTSVIVSSMFLGGVQLICLGVIGTYISKINKNIVARPLYLVAESNIAADER
>NC_015571.1|WP_004584817.1|1507250_1508159_+|DMT-family-transporter
MTSSRLYGLAVGILSSATFGLIPLFTLPISAKGASFELILFYRFFFAAIAIGILHRLSGGSFKVSRADIGPLVLLGFLYAGTALFLFHGYGYMASGVATTIHFLYPLFVTALMLLFFGERLSPVPLTAIFIALIGVGLLMGLTGGGDRVGLTGFVIVAISALCYALYIVFVNRSRIRIMPGRRLTFYVFVAAAGFCLINVLVRQGEVAPLPDAASWGNILLLALVPTVISNLALVVAVRNIGSTLTSALGAMEPLTSVLVGVWVFDEVLGASAIVGMGCILIAVGLIVFSEPLELMLRRRRR
>NC_015571.1|WP_013816152.1|1505046_1507023_+|transcription-termination-factor-Rho
MQKYTIVDLNEKAEAELAAIAGELGIANAGSMPKQELIYKILDEQAISVAGVRKEKQKTTEDRHTERRKPGRPRKNAEEEAPESKDVAAAPAEPNEEEAQAKRKRGRPRKAAEEIAEETREDVQQLVALAAAEETNATEKESAGRKPAAKTSTASPAKAPAKALPRPAETTPRVAPSPPSTTPVSEPAKDDAKPETPAPPPAIESITTTPAAGAVDEGGARRLVFRHKNSSSVLDQVLPYSSPQPPQRPKPAGAPVGSSPIRQRQAAGVPTPRREPQQSLYNFDGILECMGVLEIMPDGYGFLRSSDYNYLSSPDDVYVSQQQIKHNGLKTGDVVAGTIRPPREGEKYFPFVQLRSVNGRSPEEIRDRVPFDHLTPLFPEEKFTLEAPGIRAVNDKISVRVVDLFAPIGKGQRGLIVSQPKTGKTMLLKDIANAIAANHPEVYMIVLLIDERPEEVTDMARSVNAEVIASTFDEPAERHVKIAEIVLNKAKRMVECGHDVVILLDSITRLARAYNTVQPASGKVLSGGVDANALQKPKRFFGAARNIENGGSLTILATALTDTGSKMDEVIFEEFKGTGNMELQLDRRLSNKRIFPAVDIMSSSTRRDDLLQDETTLNRMWILRKYLSDMNPVEAMEFVRKQLENTHTNMEFLASMSN
>NC_015571.1|WP_012458422.1|1503852_1504371_-|HU-family-DNA-binding-protein
MSLKYVIKKSVAKIGPKAGQTIYYAQPAAQDSVTFHSLCKRIAEESALTSADVKGILDRLVNILSEELPNGKTVRIGELGSFRLSFGSKQLDDPKNFSVDQIQKHRLVFIPSAELKSIPARGKLRPGSSALAFDYERVEPQPKKKPGTGDNQTPSPSTPGGGGGQGGTGGGL
>NC_015571.1|WP_012458423.1|1502824_1503820_-|hypothetical-protein
MFRISRLGIVLLVSLIACNLSKAQNTTKDLINLSIKYLEQNDSTAFRKTYQDIFMQYVTEALCAPFDKAIQDRDQTYIQARLDSLTSDPEEDAFTYHLLSKPEYQAFYYTLPRWEVYKSWIDSVERNPHADMRNEIWQIQREDQGIRILWLRLPNETGDNIRKKVRDEILLVDRQNTERAIHIIDTFGEWPGANRLGCSADQTLWLCIQHADQRPEVATRYLPMLQKAVEEKRTDPMHYAYLVDRIRMHECKEQIYGTQTYHVKEENGNKFFFVIPIEDIDHVDERRAGIGMDPLSDYVNSMGYDWDIRQYKKDLPKIWKYYRHSCKKKKN
>NC_015571.1|WP_043890086.1|1501881_1502784_-|glutamate-formimidoyltransferase
MALSRIMECVPNFSEGRDREKIEKIVNPFRTREGVKLLNYSNDEDHNRLVVTVVGEPEPLREAVLEAVGIAVELIDLTKHTGQHPRMGAVDVIPFIPIKNVTAEDADALAKEVGRTIGEKYGVPVFLYEKSATAPHRENLAKIRKGEFEGMAEKIHEADWHPDFGPADRHPTAGTVAVGARMPLVAYNVNLNTNDLSIADAIAKKVRFLGGGLRFCKAMGVELTDRGIVQVSMNLTDFTKTAVYRAHEMVRMEAARYGVSVVGSEVIGLVPMQALIDCAEYYLGIENFSMDQILESRIME
>NC_015571.1|WP_013816157.1|1516128_1517328_-|methionine-gamma-lyase
MKKEDLMRSGFATRAIHGGAIENAFGCLATPIYQTSTFVFDTAEQGGRRFAGEEDGYIYTRLGNPNCTQVEEKLAMLEGGEAAASASSGIGAISSAIWVCVKAGDHIVAGKTLYGCTFAFLTHGLSRYGVEVTLVDTRHPEEVEAAIRPNTKLVYLETPANPNMYLTDIKAVCDIAHKHEGVRVMVDNTYCTPYICRPLELGADIVVHSATKYLNGHGDVIAGFVVGKEDYIKEVKLVGVKDLTGANMSPFDAYLISRGMKTLQIRMEQHCRNAQTVAEFLEKHPAVEAVYFPGLPSFPQYELAKKQMALPGAMIAFEVKGGCEAGKKLMNSLHLCSLAVSLGDTETLIQHPASMTHSPYTPEERAASDISEGLVRLSVGLENVEDIIADLKHGLDSLI
>NC_015571.1|WP_043890087.1|1517490_1518960_-|metallophosphoesterase-family-protein
MRKKRSNPYYKVSRRKFSKRNSGRRYSRKRRRNGRRWGLMISLLLLVALGIWIAKRYRAWFVSPAEVAYTVPHTIDRLTLTPGEDFLTQRTVSWRCDTLPQDSWLDYRSPDGADADTLLISLPAEGKEVLTRAGRNYYYHAKINGLKPGRTYTYRVKTGEQTSPWYRFSIPDSSAATDFIYIGDVQDPGNGGSQALLQQLRTLHPNPDFLALGGDQIEGPTDFYWEVWHRVIGDWTASTPVIAATGNHEYIKGLKRQLDPRWVPQYNYPANGPKGFERRSYYIDFPHMRLIVMDTNDIQWPASVFNHRTWLKNALETTVQPWKVVMFHHGVYSVRQGRMNPIIRYGFRSILEEGGADLVLQGHDHAYSRITTKTESGTKTTPVYIISSASPKHYRNGFSEQHDRIGSGLYLFQTIHVTQGEIRYRSTTFDNRPYDDLHLKKQGGRTTVKDNAEDWKEIFAFDNFADSKKGRKKRADYRQAAKERAAGHR
>NC_015571.1|WP_004584828.1|1518962_1519556_-|hypothetical-protein
MNKSLIILIYTLVWVLLIVLQSLALESANPGTPSFWNTPSAYYSVWIVDAYIIALYYINYFLIAPFMIKRHLFRPYIVLSLALGGIGMLLPVVFHHAWQWTIPGTSEGQMPLYGEGFIASIAAIAVGLSVRGVREWVRLARRNTNLEIALKNKSIAYDRAEARLRSLEQPVSFHNPGTGAKAENAPSSTPVSPQTNE
>NC_015571.1|WP_004584829.1|1519656_1520262_+|YihA-family-ribosome-biogenesis-GTP-binding-protein
MEIKKAAFVISNTDVRKCPDTRLPEYAFIGRSNVGKSSLINMLTGQKGLAMTSQKPGKTQLINHFIIDDSWYLVDLPGYGYARLGASNRESLRRIIETYILCREQLSSLFVLIDCRHEPQKIDLEFLQWLGENGIPFGIVFTKADKLSFSRLKENTEAYKQKLLETWEELPPVFITSSEKKTGKEELLDYIDSINQELATK
>NC_015571.1|WP_013816159.1|1520271_1521300_+|UDP-glucose-4-epimerase-GalE
MKQKILVTGGTGYIGSHTTVELQQAGYRVVSVDNFSNSNAAVLDGIARITGVRPDFYEADCNDTEAMERVFTAHPDIAGVIHFAASKAVGESVQKPLLYYRNNILSLLNILELMERFGTRGIVFSSSCTVYGQPEVLPVTEEAPIQEALSPYGNTKQINEEIIRDAIHAGAGYKAILLRYFNPIGAHPTAHIGELPNGVPQNLIPYLTQTAAGIRAELSVFGDDYDTPDGSCIRDYIYVVDLAKAHVAAIERMLNEEKASDSLEVFNIGTGRGVSVLELIRTFERVTGVVVPHRIVGRREGDIEQVWAEPKKANEVLGWKALESLEDTLLSAWRWQQRLSVK
>NC_015571.1|WP_013816160.1|1521342_1523439_+|ATP-dependent-DNA-helicase-RecG
MDILSTKITYLTGVGPKRAEVLKEEIEVRTYLDLLHYFPFRYVDRSRFYAIREIRSDMPYIQLRGVLRNFSEVGEGRRKRLTATFSDGTGSIELVWFKGIKYIRDKLQEGRRYIVFGKPVFFASGYNIAHPEIDAEEKAEQVAGGLTPIYHTTERMKSMGLGSKQLQQLLYVLLNQVSATLTETLPPYILSSYGFVSYQEAIRQIHFPQGVAQLEAARTRLKFEELFYVQLHLIGSKLERKARFQGIVFAQVGALFNTFYKEHLPFELTGAQKRVVREIRQDTLSGHQMNRLVQGDVGSGKTLVALLAMLLALDNGCQACLMAPTEILARQHHHTLSELLRPLGIEVGLLIGSCTARQRERLLPRLADGSLSIVVGTHALLEQGVAFRRLGMAVIDEQHRFGVQQRARLWEKNLDTLPHILIMSATPIPRTLAMTLYGDLDISIIDELPPGRKPIQTLHHFDSDMAPVFRFLRSQLAAGRQVYVVYPMIEGSETTDLKNLEDGFELFSSIFPDEGVTMVHGKMKAKEKEARMADFVSGRSRILLATTVIEVGVNVPNATVMVVENADRFGLSQLHQLRGRVGRGGEQSYCILITGTKTGEDSRRRIQVMVETNDGFEIAEEDMRLRGFGDLEGTRQSGRQISLRIANPARDTELIALSRSIAEQLLERDPELRHPDNQMLALRLNKLFPKEEDWSVIS
>NC_015571.1|WP_013816161.1|1523438_1524209_+|HAD-IA-family-hydrolase
MEKKESMDYNNITEALQAFRTEKAYRHAPLRSCFFDMDGVLFDSMPAHARSWVEAAGECGIAAEPLDFYRWEGQKGSDTIKILFERGYGRLPTEKEIADMYGRKSQLFALYNSGSVIDDAPALVSDVCDRGLRIMLVTGSSQTDILQRLQRSYGDNFSPANMVTGADVHRGKPHPEPYLKALECVGMSPSEAFVVENAPLGVRAAVDAGIFTIAVNTGCLPDADLWDAGASLVLPSMAVLRSLLGELLTASLSSSA
>NC_015571.1|WP_013816162.1|1524303_1525761_-|leucine-rich-repeat-domain-containing-protein
MKRKPLFSALVILSGFFGSVHPASAQKVPAPVDGERIIMELSEADVECTIKIEAEDGYANDIWADLNGNGKYDSGERLDSGEFRDVEFRQTKAIVYGKMAKFLFRGSSAGDYGATFIDISNCTGLTAFDCFANLLTELDLSKANGLTFVNCGKNQLTKLDLPANADIETLNCSKNKITSLNLSTYTKLKELYVGDNGLTALDLSANTLLEELVYSNNEVTTINLSANTNLKSLYCINNKMTGLDVAANKELKILHCNNNQLTALNLSANTKLTTLSFFNNELTNIDLSGNTALEWLFCNGNKLTKLDVSANANLIALQCSNNQLTALDLSKTPKLTTLNCYSNRIKDTAMRALIESLPTITEGEGRFVPYNDDEEGGEEENVCTTEHVEMAKAKNWKVLTSWGEPFPGITALISIEGESEYSVYAQDGILYLSGMEQGLPVQVYTVGGSMMYSSVASGSAMEIQLPRGAAYVVRIGSHAIKTAMP
>NC_015571.1|WP_080580311.1|1526325_1527768_+|exo-alpha-sialidase
MYRTLVKVALSESLPPDAKQIRIGFSLPKETEEKVTALYLLVSDSLAVRDLPDYKGRVSYDSFPISKEDRTTALSADSVAGRRFFYLAADIGPVASFSRSDTLTARVEELAVDGRPLPLKELSPASRRLYREYEALFVPGDGGSRNYRIPAILKTANGTLIAMADRRKYNQTDLPEDIDIVMRRSTDGGKSWSDPRIIVQGEGRNHGFGDVALVQTQAGKLLMIFVGGVGLWQSTPDRPQRTYISGSRDEGLTWSPPRDITHFIFGKDCADPGRSRWLASFCASGQGLVLPSGRIMFVAAIRESGQEYVLNNYVLYSDDEGDTWQLSDCAYRRGDEAKLSLMPDGRVLMSIRNQGRQESRQRFFALSSDDGLTWERAKQFEGIHDPGCNGAMLQVKRNGRDQVLHSLPLGPDGRRDGAVYLFDHTSGRWSAPVVVNSGSSAYSDMTLLADGTIGYFVEEDDEISLVFIRFVLDDLFDARQ
>NC_015571.1|WP_012458402.1|1527833_1528019_-|DUF1661-domain-containing-protein
MPEFSCLQFGKTWRVNFFALAREVKKSRTKTKKFRHHLLQKRRAAIRGFSARIGGIAVDGY

Crispr_ID: NC_015571_11

• CRISPR_ID: NC_015571_11
• CRISPR_location: 1871966-1872073
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_015571_11

Consensus_repeat	Method
GAAGCGATTTCGGCGAAAAAATTCCT	CRISPRCasFinder

spacers of NC_015571_11

>11.1|1871992|56|NC_015571|CRISPRCasFinder
TGCTGCAGCTTGCAGGAAGCTACTTTGGCGAAAAAATTCCTATTTGCAGCTTGCAA

CRISPR arrays and Neighbor proteins around NC_015571_11

CRISPR arrays

The CRISPR arrays of NC_015571_11

>merge|NC_015571|11|1871966-1872073|CRISPRCasFinder
GAAGCGATTTCGGCGAAAAAATTCCTTGCTGCAGCTTGCAGGAAGCTACTTTGGCGAAAAAATTCCTATTTGCAGCTTGCAAGAAGCGATTTCGGCAAAAAAATTCCT

>NC_015571|11|11|1871966-1872073|CRISPRCasFinder
GAAGCGATTTCGGCGAAAAAATTCCT	TGCTGCAGCTTGCAGGAAGCTACTTTGGCGAAAAAATTCCTATTTGCAGCTTGCAA
GAAGCGATTTCGGCAAAAAAATTCCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_015571.1|WP_013816407.1|1877196_1879572_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|274576
NC_015571.1|WP_013816413.1|1886661_1886946_-|NifU-family-protein	unknown	unknown	gnl|CDD|376458
NC_015571.1|WP_004585224.1|1867194_1868388_+|saccharopine-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|224662
NC_015571.1|WP_013816409.1|1882279_1882438_-|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_013816402.1|1868424_1868937_+|isochorismatase-family-protein	unknown	unknown	gnl|CDD|238493
NC_015571.1|WP_013816405.1|1872416_1874768_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|274576
NC_015571.1|WP_013816406.1|1874800_1877170_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|274576
NC_015571.1|WP_013816400.1|1866005_1866767_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187604
NC_015571.1|WP_013816412.1|1885360_1886656_-|acetyl-CoA-hydrolase/transferase-family-protein	unknown	unknown	gnl|CDD|223504
NC_015571.1|WP_004585221.1|1863700_1864294_-|indolepyruvate-oxidoreductase-subunit-beta	unknown	unknown	gnl|CDD|180732
NC_015571.1|WP_013816403.1|1869139_1870474_+|TolC-family-protein	unknown	unknown	gnl|CDD|224455
NC_015571.1|WP_013816408.1|1880606_1882160_-|PAS-domain-containing-protein	unknown	unknown	gnl|CDD|225301
NC_015571.1|WP_004585231.1|1879664_1880324_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222
NC_015571.1|WP_125026627.1|1866867_1867032_-|DUF1661-domain-containing-protein	unknown	unknown	gnl|CDD|285160
NC_015571.1|WP_012457723.1|1870513_1871767_+|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|273776
NC_015571.1|WP_013816399.1|1864320_1865928_-|indolepyruvate-ferredoxin-oxidoreductase	unknown	unknown	gnl|CDD|274526
NC_015571.1|WP_013816410.1|1882643_1883999_-|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143440
NC_015571.1|WP_013816397.1|1861434_1862505_+|iron-ABC-transporter-permease	unknown	unknown	gnl|CDD|376439
NC_015571.1|WP_013816398.1|1862548_1863307_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224045
NC_015571.1|WP_013816411.1|1884194_1885310_-|4-hydroxybutyrate-dehydrogenase	unknown	unknown	gnl|CDD|341482

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_015571.1|WP_013816407.1|1877196_1879572_+|ABC-transporter-permease	gnl|CDD|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	6.26143e-33
NC_015571.1|WP_013816413.1|1886661_1886946_-|NifU-family-protein	gnl|CDD|376458	pfam01106, NifU, NifU-like domain. This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.	1.2279e-16
NC_015571.1|WP_004585224.1|1867194_1868388_+|saccharopine-dehydrogenase-family-protein	gnl|CDD|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	3.02098e-158
NC_015571.1|WP_013816409.1|1882279_1882438_-|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.00538193
NC_015571.1|WP_013816402.1|1868424_1868937_+|isochorismatase-family-protein	gnl|CDD|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	2.64691e-32
NC_015571.1|WP_013816405.1|1872416_1874768_+|ABC-transporter-permease	gnl|CDD|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	3.07712e-20
NC_015571.1|WP_013816406.1|1874800_1877170_+|ABC-transporter-permease	gnl|CDD|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	4.81462e-32
NC_015571.1|WP_013816400.1|1866005_1866767_-|SDR-family-oxidoreductase	gnl|CDD|187604	cd05346, SDR_c5, classical (c) SDR, subgroup 5. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	5.8236e-148
NC_015571.1|WP_013816412.1|1885360_1886656_-|acetyl-CoA-hydrolase/transferase-family-protein	gnl|CDD|223504	COG0427, ACH1, Acetyl-CoA hydrolase [Energy production and conversion].	1.56665e-125
NC_015571.1|WP_004585221.1|1863700_1864294_-|indolepyruvate-oxidoreductase-subunit-beta	gnl|CDD|180732	PRK06853, PRK06853, indolepyruvate oxidoreductase subunit beta; Reviewed.	4.90894e-83
NC_015571.1|WP_013816403.1|1869139_1870474_+|TolC-family-protein	gnl|CDD|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	2.43713e-41
NC_015571.1|WP_013816408.1|1880606_1882160_-|PAS-domain-containing-protein	gnl|CDD|225301	COG2461, COG2461, Uncharacterized conserved protein [Function unknown].	6.50376e-105
NC_015571.1|WP_004585231.1|1879664_1880324_+|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	7.00946e-113
NC_015571.1|WP_125026627.1|1866867_1867032_-|DUF1661-domain-containing-protein	gnl|CDD|285160	pfam07877, DUF1661, Protein of unknown function (DUF1661). This is a family containing bacterial proteins of unknown function. Many of the proteins in this family are hypothetical.	0.000952683
NC_015571.1|WP_012457723.1|1870513_1871767_+|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	3.45071e-33
NC_015571.1|WP_013816399.1|1864320_1865928_-|indolepyruvate-ferredoxin-oxidoreductase	gnl|CDD|274526	TIGR03336, IOR_alpha, indolepyruvate ferredoxin oxidoreductase, alpha subunit. Indolepyruvate ferredoxin oxidoreductase (IOR) is an alpha 2/beta 2 tetramer related to ketoacid oxidoreductases for pyruvate (1.2.7.1, POR), 2-ketoglutarate (1.2.7.3, KOR), and 2-oxoisovalerate (1.2.7.7, VOR). These multi-subunit enzymes typically are found in anaerobes and are inactiviated by oxygen. IOR in Pyrococcus acts in fermentation of all three aromatic amino acids, following removal of the amino group by transamination. In Methanococcus maripaludis, by contrast, IOR acts in the opposite direction, in pathways of amino acid biosynthesis from phenylacetate, indoleacetate, and p-hydroxyphenylacetate. In M. maripaludis and many other species, iorA and iorB are found next to an apparent phenylacetate-CoA ligase.	1.28548e-175
NC_015571.1|WP_013816410.1|1882643_1883999_-|aldehyde-dehydrogenase-family-protein	gnl|CDD|143440	cd07122, ALDH_F20_ACDH, Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like. Coenzyme A acylating aldehyde dehydrogenase (ACDH, EC=1.2.1.10), an NAD+ and CoA-dependent acetaldehyde dehydrogenase, functions as a single enzyme (such as the Ethanolamine utilization protein, EutE, in Salmonella typhimurium) or as part of a multifunctional enzyme to convert acetaldehyde into acetyl-CoA . The E. coli aldehyde-alcohol dehydrogenase includes the functional domains, alcohol dehydrogenase (ADH), ACDH, and pyruvate-formate-lyase deactivase; and the Entamoeba histolytica aldehyde-alcohol dehydrogenase 2 (ALDH20A1) includes the functional domains ADH and ACDH and may be critical enzymes in the fermentative pathway.	0
NC_015571.1|WP_013816397.1|1861434_1862505_+|iron-ABC-transporter-permease	gnl|CDD|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.20854e-67
NC_015571.1|WP_013816398.1|1862548_1863307_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.12852e-77
NC_015571.1|WP_013816411.1|1884194_1885310_-|4-hydroxybutyrate-dehydrogenase	gnl|CDD|341482	cd14860, 4HBD_NAD, 4-hydroxybutyrate dehydrogenase, also called gamma-hydroxybutyrate dehydrogenase, catalyzes the reduction of succinic simialdehyde to 4-hydroxybutyrate in the succinic degradation pathway. 4-hydroxybutyrate dehydrogenase (4HBD) is an iron-containing (type III) NAD-dependent alcohol dehydrogenase. It plays a role in the succinate metabolism biochemical pathway. It catalyzes the reduction of succinic simialdehide to 4-hydroxybutyrate in the succinate degradation pathway This succinate degradation pathway is present in some bacteria which can use succinate as sole carbon source.	0

Protein sequences

>NC_015571.1|WP_012457723.1|1870513_1871767_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MDRKIEKKKTLIPRKYYPYAGGAIVILALAAWAVFGNHSTKFRAERARISIDSVRRGEFNDYVRINGQVQPINSIQISAVEGGMVAEKTVEEGAMVHKGDIIVRLTNPMLNLNILDSEAQLAEKQNFLRNTQVTMEQDRLNLKRESLNLRLDIERKKRKAEQYARLYKEKLCSREEYLQAGEDYQYAVEGSRLVMERQRQDSLYRGIQVRQMEESLHNMRRNLEMVRARVEDLNVKAPADGQLGLLDVEIGQTVGAGSRIGQINVLSDYKVEAMIDEHYIDRVKAGLAASFERQGRDFSLRVRKVYPEVRDKQFRTDFVFDGERPDNIRTGQTYYINLRLGQPSEAIMIPRGAFYQNTGGRWIFVVTPDGKRAVRRDITIARQNPQYYEVTSGLHAGEMVITSSYDMFGDAEEIILN
>NC_015571.1|WP_013816403.1|1869139_1870474_+|TolC-family-protein
MRFQHYLICTAAVAALAANPLTGQSNMTLEECIDYARRHSSAVALSAAELEQSKADYLQAVGNFLPRVSAGTGASWNFGRGLDAETNTYTDINSFNNSYSIHATMTLFDGLQSVYRLRMAHARRESSRLSVREQQELAALGTTEAYYDLVYARQMQELAMQKYEESNRLHRQTARMEELGMKSRPDVLEMQSRMAGDRLTLTQADNQCIIALIRLKEKMNFPIDDELVLDDMPADSLSADMAESDSSAGVFARAAHHHPVLLRAKLDEQAATDRLRAARGAFLPSVSVSGGWNTGFSRFLNGSDYTPFSEQFRNRRGEYVSLNLSIPIFSGFSLVSNLRQARAERRAAIVRRGEAERRLYSEIAQAMADRDAALASYRQAKEHTDAMQTAYEAVLQRYEEGLNTAIDLTTQANRLLDARVQRLRAAMTYRLKCKLIAYYGCLSD
>NC_015571.1|WP_013816402.1|1868424_1868937_+|isochorismatase-family-protein
MVLLIVDPQVDFVSGSLAVEGAPKAMKALAEYMAAHRKEIKSIVVTMDQHPADHCSFVAQGGQWPSHCVRYTVGAAIEPCIAEALAACSAEGIPVEMIEKATTQERDAYSAFETEVPDSLRSTERIVVAGIAGDYCVRQSVLDLERHGLGERIELLKEGIAYIAEEENRP
>NC_015571.1|WP_004585224.1|1867194_1868388_+|saccharopine-dehydrogenase-family-protein
MGKVLIIGAGGVGTVVAKKVAMNTDVFTEIMLASRTRSKCDKIASEIKNVRIQTAQVDADNVEELVALFESFKPELVINVALPYQDLTIMDACLRCGVNYLDTANYEPLDEAKYEYSWQWAYQDRFRKAGLTAILGCGFDPGVTSVYTAYAAKHHFDEIHYLDIVDCNGGDHHKAFATNFNPEINIREITQKGKYWENGRWIETEPQEIHKTLTYPSIGERESYLLYHEELESLVKNFPTIKRARFWMTFGQEYLTHLRVMQNIGMTRIDPIMYNGVEIVPIQFLKAVLPNPGDLGENYTGETSIGCRIRGIRDGKEHTYYIWNNCSHEVAYKETGTQGVSYTTGVPATVGAMMFMKGIWRKPGVFNVEEFDPDPFLEEVAKQGLPWHEKHDIDLEL
>NC_015571.1|WP_125026627.1|1866867_1867032_-|DUF1661-domain-containing-protein
MPCHKTWCVNFFVLVREVKNSRATTKKFSRHFVQKTRATIRSFAVRISDKTDPD
>NC_015571.1|WP_013816400.1|1866005_1866767_-|SDR-family-oxidoreductase
MNPIALITGATSGIGAASARRLASLGYNLIITGRRSERLQNIADEIRAEYPVEILPLSFDVRNREEVETHLGNLLDPWQAVSVLVNNAGLAAGLDPIQSGDIEDWERMIDTNIKGLLYVTRTISPGMIARSAGHIINIGSIAGKEVYSNGNVYCATKHAVDALSKAMRIDMLPYGIKVTQICPGAVETEFSLVRFHDDQAKADAVYKGFTPLCANDIAECIAAVLNLPDNICINDMVVMPKAQAGSGHFFKQV
>NC_015571.1|WP_013816399.1|1864320_1865928_-|indolepyruvate-ferredoxin-oxidoreductase
MQKQLLLGVEAIAQAALDAGISGVYAYPGTPSTEITEHIQNSRMAKERNIHREWAANEKTAMESALGMSYAGKRALVCMKHVGMNVAADCFMNAAITGANGGMVIVAADDPSMHSSQNEQDSRVYGQFAMIPVMEPSNQQEAYDMTRLAFDLSERLGTPVMMRITTRLAHSRAGVVQTEPIGENELHLPEDKRQYVLLPGIAKKRYRILLDKQTDFVRESENSPYTEYVDAADKSKGIVACGIAYNYLMEAFKAQVPYPVLKVTQYPIPHKQMERLLNECGDIVIMEEGYPVVEQLLKGFPGLERIKGRLDGTLPRDGELNPDHVAKAFNIPVVEGEPIPDLVAARPPALCKGCSHRDVYDALNEVLTEYPNGRVFSDIGCYTLGALPPYEAINSCVDMGASITMAKGAADAGLFPAVSVIGDSTFTHSGITGLLDAINENSNITVIISDNESISMTGGQHSSAYGKVEAICRGIGVDPDHIKELLPVPKNHDELCSIIREEINYEGVSVIIPRRVCIQKHARDAKAAKRAKAKE
>NC_015571.1|WP_004585221.1|1863700_1864294_-|indolepyruvate-oxidoreductase-subunit-beta
MKTDIILAGVGGQGILSIAAAIGSAALTNNLYLKQAETHGMSQRGGDVQSFLRLSDAPIYSDLIPIGGADLILSVEPMEALRYLPYLKPDGYVVTNTVPFINIPNYPETTSVISKIESLPHHVLIDADSIARDEVGNVRASNFVMLGAASPFIEIPFDYLAGGIEAIFSRKGQEVVDMNLKALNAGREFALRYAAGK
>NC_015571.1|WP_013816398.1|1862548_1863307_+|ABC-transporter-ATP-binding-protein
MEKSIELSRLAIGYRTKSGDRIVASGLEAHLHAGQLTALLGVNGAGKSTLMRTMAGFMKPLSGQIHLLGRSLDSYKEIEIAKRIGVVLTDNCRIAGMTAGELVALGRSPYTGFWGRLQKGDRKLVAEAVERVGIAPLINRELTTLSDGERQKVVIAKALAQQTPIIFLDEPTAFLDYPSKMELLYLLHSLAHDTGRTIFLSTHDLDAILPMADRVWLLDKERPFREGTPASLASALEDYFGYTHLSPTSEPV
>NC_015571.1|WP_013816397.1|1861434_1862505_+|iron-ABC-transporter-permease
MTSVSHLRTISIAGILAALGGAVLILFGVNLFLGSVAIPMSEIFRHLFSDRPEGGEALVHYNILWKSRLPEALTAAFAGAGLSVSGLQMQTVFRNPLAGPSVLGISSGASLGVALVVLLSGSLGGVALSSLGYMGEVAMNIAAAVGSLAVMGLIVFVSTKVRSHVTLLIIGVMIGYVANAVIGVFKFFSIEEDIRAYVIWGLGSFSRATDSQLSFFAILMLIFIPAGMLLVKQLNLLLLGESYARNLGLNTRRARLLVISSAGLLIAAVTAYCGPIGFLGMAVPHLARVIFHTSDHRILMPATCLIGSALALFCNIIARMPGFEGALPVNSVTALVGAPIIVTVLFRRRRFKEETD
>NC_015571.1|WP_013816405.1|1872416_1874768_+|ABC-transporter-permease
MRTYFKFLSRNKLYTFVTIVGFALSLIFVLLLSFYVRREQQADRIHTDYKRIYQYNVESKNNWSGFICCYPAGTLIREQVPDVEEICRISEYNDKEYIFIGADKQNGLIASHLSVESNFFTFFDGYKLLEGDPKTVLSEQNSAVISSALAARIFGNMSPIGQEISFFDFSKNKQTFRITGIMEPMPDNCHIRPAELLFYQEPKENNYNNGNYALYLKAREGADLTAQLPAVQKTVQGKDVIFAFDEKAEVKLHPLEKCYPEPLFPNEYAMMVQKGNPARTRILIAITLLVLIIAIISYINLTLAQGGSRGNEVALRRLWGSSRLAIVRRLWFESLLLIFLSTLLAVFGMFALEPVFDRLFDTHLYLARHISLTLILLLIGFMLLLSIVCAALPAWFISRFRPIEVVSGKFRRVVKSSFSQIMVISQYAITMILLSCTMVMAVQIDYMTNSDMGYDYRNKLIIDVFGLDPQIVSTMRTEIAKIPGITGIGLTRGTPLNGGNNNSSEYRGRPLSMQIFSIDSVALSLFDLKMKPNGRKADKPDRTLYLSRSAYNDFDVANLPDGVIHWGKAGEFYYCGDAPEVHFGGFKEPHPSYLFIPYPQSSAWSWSVLVGYSEGADPEQLIQSIQAVYSRITGQPYTEILRSEDIIASHSEEERSLSGFLLLFSILALVGTVMSVFAMAALRIRHKQKEIAIRKVVGAREVQILQIIGRRSLWNLLIAFAVASPASYLVMNRWLQGYTYHADMPWWVFPASLLFVSAVAMLSMLSMAMNAASSNPVDYLKNE
>NC_015571.1|WP_013816406.1|1874800_1877170_+|ABC-transporter-permease
MRTYFKFLSRNKLYTFVTVFGFSVSLMFVILLGFYVQGELSVDNFHSKGDRIYMLRSELHACLSNPAPAYVQELVPEVEAYCRIANADLYIETTDGEKIKTSILLVDSTFFTIFDFKLRTGQPDDVLSLRRSIVLTPETARRFFGNDDPKGRILHDKLTVSGIMEPIPFYSQFPQVDAVVSYDYIEELFGSELLSGWGYFQFSAYFLMKPHTNIQAKAKVLEKIFTGEESPLGLWRSGYAKEVHFVPLKKCYYDPLVITSRFDIRKNDASKVYILLAIVLLILFIAILNYINLTVAQAGFRGKEAAVRRLLGESQKGLIRRYLGESFLITFISFLLGLLLAFILEPFFDRVLDTRINLISRFTYQTIIVIVSSIVILSFASGLLPSIVISHFKPIEVVKGYFSYRIKSNYSHFLVILQYTVSLILVTCSLIILMQSHFLIHTDLGFRTHGIMLISNNLDSVPQESLRNEIQKIPGVDMVSFSSGNPVNIANNVAFNDDGERAQFTWEMMIDSLFFDFFEIKPKYITQEPREVLFNGDRFRKTHLMPSWATASMVNVVHPDPNTHEFTRGSYKQYDGLTHVMVGILPEIKYRPLNESHDPLLIYPLQRGQYPWTTMVRVRDSIDRKAVEKTILETYKRIGNVDDVKWHWAEDIILDRYKSQTNLSQLISAFALLTVLIMVMGVFAMSLYMIKQKEKEIALRKVNGATVATILAMLNIRSLRRFGIALLIALPVSWWAMDRWLQTFAFHIRLDWWVFVVAALIVLLLSLVSTSLQSWRAACANPVDYLKNE
>NC_015571.1|WP_013816407.1|1877196_1879572_+|ABC-transporter-permease
MLPLKLAARRLFRQGEHSISKLLTLTLGLSVSVLLLSIVIYQRSYERDFPHHDRICIVKTHGTRQSQEGDKPEELDFSQVSGGVAPAIQEEIPGVELATRTTLYGTSKMILEDNKTYETKTLLAEPAFLDMFGVELIAGVRDSALRDNMTCLISESLARKMGGDVLGKRLRPAESKSDRAITIGGVFEDLPHNSSIQADMLLPITWMPAESLNNWIGNDRYIAYVRLRPGVSPESLDEALLEMQKRHQDMEVFRKAGVELHYSLTPFNRLRLEDPTLVNMLRIQQIVAIAVLLISLLNYVLMTLASMVNRRRVAAIRKCYGAMPVQIQGTMIWETFLYLFLSLVLALLTLILFRKPMEALIETPLLHLISWRVAAALAGVLAMATFFMGWIPGYSLSRTPVMNIFRKSVAHNRLWKLGLLAVEFVAASFLFGLLAITGLQYRHMIGQDAGYKAAGLYYVPIESLDQQQLPVVIEKLKALPEVEGYTLTTALPASSGQSGDNLIDPVTDRELINVADLFYVDEHYLKVYDIELLEGKNFDAATEKDREIMLSKKAATELARLMNWKDGVIGKNIILTSFGRVVIRGVYDDLMLRRQHLSPYPEKLPSAIVYGDDWLHYLTIRLRHDDARLLHRVNGILSEADPYKETSFLSVEMELLSRFEAAKTFRNTILFGSVVAILIALIGLVGYVNTEVNRRRKELAIRKINGAGEGDILRLFLRSIFRLSLPSVLAGLFVAYLFGRNWLEKFSYRIELNGRIFLLVGLFVLLIIALAVVINLRRIARRNPVNELRYE
>NC_015571.1|WP_004585231.1|1879664_1880324_+|ABC-transporter-ATP-binding-protein
MIEISNLTKVFRTEEIETVALDGVSLKVDKGEFIAIMGPSGCGKSTLLNILGLLDNPTSGIYKLDGAEVGNLREKDRTAVRKGNIGFVFQSFNLIEEMTVSENVELPLVYLGVKASERKERVEEALRKMSISHRAGHFPNQLSGGQQQRVAIARAVVANPKLILADEPTGNLDSKNGADVMELLRGLNREGATIVMVTHSEHDARSAGRIINLFDGKIR
>NC_015571.1|WP_013816408.1|1880606_1882160_-|PAS-domain-containing-protein
MQDIKTNETFDSLDKSKLERMLDIKEAHREGHLTLEEAKERMKKEVGSISPEEFAAAEQLFKERDQDECQNEDVRTMLQLFEGLINPIRPDLPFGHPIDAYLRENDKAKELLDQADALLERTFIPNPWIELMETLMGYKLHFARKQNQLYSTLEQKGFDRPSTTMWTYDDHIRDEMNKAMSLLREKDYDSFPAAYKEMAIVLRDLMEKEELILYPTSLKLISDKEFEAMKHGDREIGFFLIDMPELDAPAKQSKEAHGQSFMAELGALLAKHGMGTGGQDDKAILDVAEGKLTLEQINLLFRHLPVDISFVDENELVCFYTDTKHRVFPRSKGVIGREVRNCHPPKSVHIVEEIIDKFRRGEQDRAEFWINKPGVFIYIVYVAIRDADGRFRGVMEMMQDCTRIRSLEGSRTLLTWDEEQSPAQGSKESESDTVGEDGIRPDTKLKSLLQRYPRLMDDLPTISSKFTLLRSPMAKVILPVATIKMMSERADIPSDMLIGKLESLIASYNKPDRSEEK
>NC_015571.1|WP_013816409.1|1882279_1882438_-|DUF1661-domain-containing-protein
MNFLLLAWEKKKSETKTKKISRLLFTKYRPQSEHFRLVSCLRRNEHMHFFPR
>NC_015571.1|WP_013816410.1|1882643_1883999_-|aldehyde-dehydrogenase-family-protein
MEIKEMVSLARKAQKEYQATHNQEAVDNICRAAAKVIYENAAILAREAVDETGMGVYEHKVAKNQGKSKGVWYNLHNKKSVGILNIDERTGMIEIAKPIGVVGAVTPTTNPIVTPMSNIIFALKTCNAIIIAPHPRSKKCSAHAVRLIKEAIAPFNVPEGMVQIIEEPSIEKTQELMGAVDVVVATGGMGMVKSAYSSGKPSFGVGAGNVQVIVDSNIDFEAAAEKIITGRAFDNGIICSGEQSIIYNEADKEAVFTAFRNHGAYFCDEAEGDRARAAIFENGAIAKDVVGQSVAFIAKKANINIPEGTRILVVEARGVGAEDVICKEKMCPVMCALSYKHFEEGVEIARTNLANEGNGHTCAIHSNNQAHIILAGSELTVSRIVVNAPSATTAGGHIQNGLAVTNTLGCGSWGNNSISENFTYKHLLNISRIAPLNSSIHIPNDKEIWEL
>NC_015571.1|WP_013816411.1|1884194_1885310_-|4-hydroxybutyrate-dehydrogenase
MQLFKLKSVTHHFDTFAEFAKEFCLGERDLVITNEFIYEPYMKACQLPCHFVMQEKYGQGEPSDEMMNNILADIRNIQFDRVIGIGGGTVIDISKLFVLKGLNDVLDAFDRKIPLIKEKELIIVPTTCGTGSEVTNISIAEIKSRHTKMGLADDAIVADHAIIIPELLKSLPFHFYACSAIDALIHAIESYVSPKASPYSRLFSEAAWDIILEVFKKIAEHGPEYRFEKLGEMIMASNYAGIAFGNAGVGAVHALSYPLGGNYHVPHGEANYQFFTEVFKVYQKKNPFGYIVELNWKLSKILNCQPEYVYPKLDELLGCLLSKKPLREYGMKDEEVKGFAESVLKTQQRLLANNYVELTVDEIEGIYRRLY
>NC_015571.1|WP_013816412.1|1885360_1886656_-|acetyl-CoA-hydrolase/transferase-family-protein
MKDVLAEYASRIVSAEEAVKHIKNGERVALSHAAGVPQSCVDALVQQADLFQNVEIYHMLCLGEGKYMAPEMAPHFRHITNFVGGNSRKAVEENRADFIPVFFYEVPSMIRKDILHIDVAIVQLSMPDENGYCSFGVSCDYSKPAAESAHLVIGEINRQMPYVHGDNLIHISKLDYIVMADYPIYSLAKPKIGEVEEAIGRNCAELIEDGATLQLGIGAIPDAALLFLKDKKDLGIHTEMFSDGVVELVRSGVITGKKKTLHPGKMVATFLMGSEDVYHFIDKNPDVELYPVDYVNDPRVIAQNDNMVSINSCIEVDLMGQVVSECIGSKQFSGTGGQVDYVRGAAWSKNGKSIMAIPSTAKNGTTSRIVPIIAEGAAVTTLRNEVDYVVTEYGIAQLKGKSLRQRAEALIAIAHPDFREELTEHLRKRFG
>NC_015571.1|WP_013816413.1|1886661_1886946_-|NifU-family-protein
MTEEIVELVLREQISPLLRSHGGDLSLSQIKDKTVFVRFSGACRFCPAAHETVEKIVQAMIREYFKDDNIDVILENSVSDDLLEQAKNILRKPK

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_015571_2	2.1|237493|38|NC_015571|CRISPRCasFinder	237493-237530	38	NC_015571.1	587742-587779	0	1.0
NC_015571_4	4.3|259804|41|NC_015571|PILER-CR,CRISPRCasFinder,CRT	259804-259844	41	NC_015571.1	63698-63738	0	1.0
NC_015571_5	5.4|293851|36|NC_015571|CRISPRCasFinder,CRT	293851-293886	36	NC_015571.1	2170216-2170251	0	1.0
NC_015571_5	5.20|293852|36|NC_015571|PILER-CR	293852-293887	36	NC_015571.1	2170216-2170251	0	1.0
NC_015571_6	6.1|296114|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT	296114-296149	36	NC_015571.1	296048-296083	0	1.0
NC_015571_6	6.2|296180|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT	296180-296215	36	NC_015571.1	296048-296083	0	1.0
NC_015571_6	6.3|296246|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT	296246-296281	36	NC_015571.1	296048-296083	0	1.0
NC_015571_6	6.4|296312|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT	296312-296347	36	NC_015571.1	296048-296083	0	1.0
NC_015571_7	7.13|605216|36|NC_015571|PILER-CR	605216-605251	36	NC_015571.1	2170216-2170251	0	1.0
NC_015571_7	7.23|605209|36|NC_015571|CRISPRCasFinder,CRT	605209-605244	36	NC_015571.1	2170216-2170251	0	1.0
NC_015571_10	10.1|1515113|30|NC_015571|CRISPRCasFinder,CRT	1515113-1515142	30	NC_015571.1	2220382-2220411	0	1.0

1. spacer 2.1|237493|38|NC_015571|CRISPRCasFinder matches to position: 587742-587779, mismatch: 0, identity: 1.0

attactacgggaaagcccagcgaacgcattgccggaat	CRISPR spacer
attactacgggaaagcccagcgaacgcattgccggaat	Protospacer
**************************************

2. spacer 4.3|259804|41|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to position: 63698-63738, mismatch: 0, identity: 1.0

cgggagtgcgacaagatacttggctccggccgcacgattgg	CRISPR spacer
cgggagtgcgacaagatacttggctccggccgcacgattgg	Protospacer
*****************************************

3. spacer 5.4|293851|36|NC_015571|CRISPRCasFinder,CRT matches to position: 2170216-2170251, mismatch: 0, identity: 1.0

ggcgtaccccctatgacagctacccggctactcatc	CRISPR spacer
ggcgtaccccctatgacagctacccggctactcatc	Protospacer
************************************

4. spacer 5.20|293852|36|NC_015571|PILER-CR matches to position: 2170216-2170251, mismatch: 0, identity: 1.0

ggcgtaccccctatgacagctacccggctactcatc	CRISPR spacer
ggcgtaccccctatgacagctacccggctactcatc	Protospacer
************************************

5. spacer 6.1|296114|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to position: 296048-296083, mismatch: 0, identity: 1.0

tgtcatatagatatgacatcttagatattggtacta	CRISPR spacer
tgtcatatagatatgacatcttagatattggtacta	Protospacer
************************************

6. spacer 6.2|296180|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to position: 296048-296083, mismatch: 0, identity: 1.0

tgtcatatagatatgacatcttagatattggtacta	CRISPR spacer
tgtcatatagatatgacatcttagatattggtacta	Protospacer
************************************

7. spacer 6.3|296246|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to position: 296048-296083, mismatch: 0, identity: 1.0

tgtcatatagatatgacatcttagatattggtacta	CRISPR spacer
tgtcatatagatatgacatcttagatattggtacta	Protospacer
************************************

8. spacer 6.4|296312|36|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to position: 296048-296083, mismatch: 0, identity: 1.0

tgtcatatagatatgacatcttagatattggtacta	CRISPR spacer
tgtcatatagatatgacatcttagatattggtacta	Protospacer
************************************

9. spacer 7.13|605216|36|NC_015571|PILER-CR matches to position: 2170216-2170251, mismatch: 0, identity: 1.0

gatgagtagccgggtagctgtcatagggggtacgcc	CRISPR spacer
gatgagtagccgggtagctgtcatagggggtacgcc	Protospacer
************************************

10. spacer 7.23|605209|36|NC_015571|CRISPRCasFinder,CRT matches to position: 2170216-2170251, mismatch: 0, identity: 1.0

gatgagtagccgggtagctgtcatagggggtacgcc	CRISPR spacer
gatgagtagccgggtagctgtcatagggggtacgcc	Protospacer
************************************

11. spacer 10.1|1515113|30|NC_015571|CRISPRCasFinder,CRT matches to position: 2220382-2220411, mismatch: 0, identity: 1.0

gatgtggctgtagatgcactcttccgcaaa	CRISPR spacer
gatgtggctgtagatgcactcttccgcaaa	Protospacer
******************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015571_6	6.13|296907|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT	296907-296940	34	NZ_CP033246	Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence	714094-714127	7	0.794
NC_015571_6	6.13|296907|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT	296907-296940	34	NZ_CP033248	Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence	714110-714143	7	0.794
NC_015571_6	6.13|296907|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT	296907-296940	34	NC_029073	Geobacillus virus E3, complete genome	39503-39536	7	0.794
NC_015571_9	9.1|786801|29|NC_015571|CRISPRCasFinder	786801-786829	29	NZ_CP024656	Bacillus cereus strain MLY1 plasmid pMLY1.2, complete sequence	41975-42003	7	0.759
NC_015571_10	10.2|1515179|30|NC_015571|CRISPRCasFinder,CRT	1515179-1515208	30	MN694560	Marine virus AFVG_250M172, complete genome	19299-19328	8	0.733
NC_015571_5	5.14|294508|34|NC_015571|CRISPRCasFinder,CRT	294508-294541	34	HQ634175	Cyanophage P-RSM1 genomic sequence	130428-130461	9	0.735
NC_015571_5	5.30|294509|34|NC_015571|PILER-CR	294509-294542	34	HQ634175	Cyanophage P-RSM1 genomic sequence	130428-130461	9	0.735
NC_015571_6	6.60|300001|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT	300001-300035	35	NC_009806	Kineococcus radiotolerans SRS30216 = ATCC BAA-149 plasmid pKRAD01, complete sequence	92086-92120	9	0.743
NC_015571_6	6.63|300198|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT	300198-300232	35	NZ_CP007231	Yersinia similis strain Y_sim_228 plasmid unnamed, complete sequence	29435-29469	9	0.743
NC_015571_6	6.63|300198|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT	300198-300232	35	NC_011759	Yersinia pseudotuberculosis pGDT4 plasmid	20547-20581	9	0.743
NC_015571_7	7.3|604552|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT	604552-604585	34	HQ634175	Cyanophage P-RSM1 genomic sequence	130428-130461	9	0.735

1. spacer 6.13|296907|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033246 (Clostridium butyricum strain CFSA3987 plasmid pCFSA3987, complete sequence) position: , mismatch: 7, identity: 0.794

taaataatcatttaattgtaacattttgtgaata-	CRISPR spacer
aaaataatgatttaattgtaaaattatat-agtat	Protospacer
 ******* ************ *** *.* *.** 

2. spacer 6.13|296907|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033248 (Clostridium butyricum strain CFSA3989 plasmid pCFSA3989, complete sequence) position: , mismatch: 7, identity: 0.794

taaataatcatttaattgtaacattttgtgaata-	CRISPR spacer
aaaataatgatttaattgtaaaattatat-agtat	Protospacer
 ******* ************ *** *.* *.** 

3. spacer 6.13|296907|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to NC_029073 (Geobacillus virus E3, complete genome) position: , mismatch: 7, identity: 0.794

taaataatc--atttaattgtaacattttgtgaata	CRISPR spacer
--gattatctgctttaattgttacattttgtaaata	Protospacer
  .** ***   ********* *********.****

4. spacer 9.1|786801|29|NC_015571|CRISPRCasFinder matches to NZ_CP024656 (Bacillus cereus strain MLY1 plasmid pMLY1.2, complete sequence) position: , mismatch: 7, identity: 0.759

tcttccctccatttgctttcatctttgcc	CRISPR spacer
ccttccatccatttgctttcatatattta	Protospacer
.***** *************** * * . 

5. spacer 10.2|1515179|30|NC_015571|CRISPRCasFinder,CRT matches to MN694560 (Marine virus AFVG_250M172, complete genome) position: , mismatch: 8, identity: 0.733

gaagtggccaatgttcgataggctgctcag	CRISPR spacer
gaactggccaatgtttgataggccatgacg	Protospacer
*** ***********.*******...   *

6. spacer 5.14|294508|34|NC_015571|CRISPRCasFinder,CRT matches to HQ634175 (Cyanophage P-RSM1 genomic sequence) position: , mismatch: 9, identity: 0.735

tagaacatactattaataatacatcaagaacatc	CRISPR spacer
aagaacaaactattaagaatacatctgaagcaca	Protospacer
 ****** ******** ******** ..*.**. 

7. spacer 5.30|294509|34|NC_015571|PILER-CR matches to HQ634175 (Cyanophage P-RSM1 genomic sequence) position: , mismatch: 9, identity: 0.735

tagaacatactattaataatacatcaagaacatc	CRISPR spacer
aagaacaaactattaagaatacatctgaagcaca	Protospacer
 ****** ******** ******** ..*.**. 

8. spacer 6.60|300001|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to NC_009806 (Kineococcus radiotolerans SRS30216 = ATCC BAA-149 plasmid pKRAD01, complete sequence) position: , mismatch: 9, identity: 0.743

cctccgcccccagcccgctatcgacccccacctgc	CRISPR spacer
ccctggatccccgcccgctgtcgacccccacctcg	Protospacer
**.. * .*** *******.*************  

9. spacer 6.63|300198|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007231 (Yersinia similis strain Y_sim_228 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.743

acttcgccgtccgcggtaatgtgaccaataccgac	CRISPR spacer
atatcgccgtacccggtaatgtgaccaacagtgtt	Protospacer
*. ******* * ***************.* .* .

10. spacer 6.63|300198|35|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to NC_011759 (Yersinia pseudotuberculosis pGDT4 plasmid) position: , mismatch: 9, identity: 0.743

acttcgccgtccgcggtaatgtgaccaataccgac	CRISPR spacer
atatcgccgtacccggtaatgtgaccaacaatgtt	Protospacer
*. ******* * ***************.* .* .

11. spacer 7.3|604552|34|NC_015571|PILER-CR,CRISPRCasFinder,CRT matches to HQ634175 (Cyanophage P-RSM1 genomic sequence) position: , mismatch: 9, identity: 0.735

gatgttcttgatgtattattaatagtatgttcta	CRISPR spacer
tgtgcttcagatgtattcttaatagtttgttctt	Protospacer
 .**.*.. ******** ******** ****** 

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	2083822 : 2135169	43	Ralstonia_phage(33.33%)	transposase,protease,integrase	attL 2099808:2099823|attR 2142958:2142973

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_015571|2083822:2135169|DBSCAN-SWA
CATGGCATACCAATCCAAGAATACCGATGAGCATGTAACATTTGCAGACGCACTCCTTTCAAAGCGTTATCGCAAAGCACAAAACGACTTCCTCAATCAGGTTGACAGGCTTATCGATTGGCGTCCGATCAGGACGCTGATCAACAAGAAATACACGAAGCGGCAAAATGCCATCGGCGCCCCGGCTTATGACGTGATTCTCTTATTCAAGATGTTGCTTTTGGAGACATGGTACAACCTCAGTGATTGTGCTTTGGAGGAGCGCATCAATGATTCGATCACCTTTTCCCGATTCTTGGGGCTGAAGATGGAAGAGGTATCTCCCGACCACAGCACCATCAGTCGATTTCGTTCGGCACTGACAGAGTTGGGTCTCATGGACAAACTATTGGCGCAGTTTAACAAACAACTTTCCCGCCATCACATTTCGGTAAGGGAAGGGGTGCTTGTCGATGCAAGCCTTGTGGAGACGCCGCACAAACCCAACGGAACCATTACGATTGAAGTCGCAGACGACAGAGAAGACAATCGGAGCGAGGCGGAAAAAGAGGCAGAGGAGGATTATCAAAAACAGGTTGTCCGTCAACGTAAAGGGACGGATGAAGAAGCCCGTTGGGTGTACAAACAAAAGCGTTATCACTACGGATACAAAAAGCATTGTCTGACCAATGTTCAAGGCATTGTTCAAAAGGTGATAACGACTGCAGCGAACCGCAGTGACACGAAGGAGTTTATTGCGCTATTGCAGGGTGCAAACATACCTCAAGGCACAGCCGTCTTGGCGGACAAAGGATATGCTTGCGGGGAAAATCGTTCCTACCTGCAAACCCATCACCTTCAAGACGGCATTATGCACAAGGCACAACGCAACAGGGCATTGACCGAGGAAGAGAAGCAACGAAACAAAGCAATCGGTCCGATACGGAGCACCATCGAACGCACCTTTGGCAGTATTCGGCGGTGGTTTCATGGCGGACGATGTCGATACCGGGGACTTGCCAAGACCCATACTCAAAACATTCTTGAAAGCATCGCCTTTAATTTATACAGAACCCCGGGGATAATTATGTCCTCATCTCTAGGATAAGGCATAACCACCCTTGAGGAGCTCGTGCAAGCAGCTCCTCAAGGGGGGATTTACAACTACTTTCACTCCTTACTGCCACCCCTTTCACTCGCTCCTTTTATGCGAAGAACTCCTCTTCCCTCCACCTCCTTATTTTTCAAAGGTCTCAGCAAAGCGAAACATCCAACCGAAAATTGAATCTCCGGCTGCAAATGTTCAAGGAGAAGATAGAGCGGGTTTACGTCGAGACTCTTCGACGTGACGGGGTTATCAGTGCCGAGTTGCTGAAGAATCATTTGCAGAGAATAAACTCCGTTCCGGCGATGCTTTTGGAAGCAAGCCGGACAGAATTGCAATCGATTGAAGCATGTATCGGTAAATCCAAAAGCAAAAGTACATACCGAAACAATTTTTACTGCGACAAGAAATTGAGTCATTTTGTCAGCAATAAGAGCAAAATAGACGTTCCGATATCGATACTGAGCATTGCTTTTTTCGACGAATATCGTTTCCACCTGAAAAAAAAGAGGGTTATGCTCCTGCTACCATCAACAAGCATCTTTGCTGGTTGAGCCGCCTGATGTACAAGGCTGTCAGCCGGTGGATGATTCGCTTCAATCCCCTTTTTTTCAGAAATTTGATATCGCCAAGACTACTGGCATTCCCGTGCAGCATAAGGAGACGGAACTCTGCCGGAGGATGTTTCTTTTCTCGGTCTTTACAAGCTTGGCTCTTGTCGACTGCAAAGTTTGCGCACCTCGCACATCAAGATGAACGGAGAAGGGAAACGTTATATCCGGAAAACAAGATAGAAAACGGAAGAGGAAAGTCCTATTCCCTTGCATCTGATAGTGGAACAGATTCTTGCGCTTTATATGAAAAATGAAGACAATGGAGGTGATTACATGATATTTCCTGACCATATAAGTGTTGGGAAGTTGAAGAACCGGTTGAATGCCGTTGGTTTGGCATGCGGTATCCGGCAACCACTAATCTGGCACCTTACTGGATATTGCAGATTGTCTTTGCCCTTGAAAATAAATAGCTTGCAGGAATTTACATCTTGACAGGTAACGATTTAGAAACGAGCGAAGTTCTATATTCTGTCTTGTCTTACATTAAATCAAAAGAATACCTTTATAGCCGCAAATTTAATAAAAATCGCGAGGTATCTACACCGACATAATAAAGTGCATCTGTAGAGTCCAATAACACACTTTTTTGTCAGTTGAAGAAAAACATTTTCTTTATGATGTCTGTGTATTCTCACGTATTTGATGTATCTTCGCACGATAAATTGGATATGTTGTATGTGCATACTACCAGTATATAGCATATGACTGAACTTGAAAATATTATGAGTAGGCAAATATATCTACCAGAGTTGTTAAGTATAAACATTAAGAATTATACTTTATACCCTAATGGTTTGGATTACACTTTTGATTTTGTCAAAGGTGTAAATCTTGTGTTAGGCGGTAATGGTATGGGAAAAACAACTTTTGTCAATATTATTAGATTTGCCATTCTTGGTTTATACAAAAAGCCTTTTGGATATACCCGTACTTACCAAGGGAGTATTATAGAAAAACGCCAATTGTTTCCACAAAAGTATTTCAGCAATCGTATGGACGACAGTGTTCACACGGATACTTCTCCTACCGTATCGATTAGCATGAAGATAAACAATGTCACAGTTGAATTGACGAGAGATTTATCTTCAATAACTTTGACTCAGCTAAAGGTTAATGGAACTGAAGTATCTGGTACCTTAGTCAATCAATTCAGCTACGAAAAATTATCGGATGTTGCAAAAGCTGATACGTTACCTTATAAATATGAGGAAATCATAAAGGTCAACACTAATTTGGAATTTGACGATTTGATATTTTTTGTAAATGAAGTCCTTTTTTTTGGAGAAGACCACAAGACAATTCTTTGGAACGATGGCGACTTCTTTCCGGATGTACAAAGTGAACTGTTCAACAAATATTTCAACGATCCAGATCTTGACAAGAAACGGCAAGAGGCTATCAGAAAAGCTAAATATTTTGACAGTTTGTCTCGCCATAGTTCAGAAGATATGCGAGCTATCAATAAGGTTTTGAGCAAAATGAAGGACGCTCCAGTAACAGGCAACTCAATAACCAATAAGGGAAATACAGCACTTATTCTGATTGATTTGAAGGGGAGGCTTGTGGAAATGGATGCCAAACTGGCAGCCATACAAAAAGAACGTGCTTCGAAGAGTCAGGACATATCACTATTGCAGAATGATATCAATAAAATTAGCTTATCTACAAACGATATAGACAAGGAGTTAAAACAAATAGAGGATAAACTAAACAGCCATATATGGGAAACCCTTCACCCCTCATATCATGTTTTCATAAAGAATATTCAGCTGAACCGCATCTGTCCGATGTGCAATCAGCCGAATGATGACTTGGTCGCGAAAGTTACAAATGAACAAAATAACTGTTTCGCATGCAGTACTCCGATTAATACAAACACTGAGGCAGATACAATACTGAGAAAGCACTTTGATGAAATAAGTACACATAGAAAAACTTTGTATCAGTCCATCAATAGCAAAAAACAAACGATACAAAATATTGAGCAGCAAATTATTAAATTAGACTCCGAATTTTCCAAGATTGAATTGGAAAGAAGAGCAATTCAGCAAAAAGTCAGGGAACTTGAGTATGAAAATGCCATGTCTGATAACAGTCAAAATTCCATTCAACCATTCTTGGATGAGGTAAATCGTCTGACACAACAAAAGGAGGCATACCAAAAACAACGTGACGAGCAGTATGATATCGTAACGTCCATTTCAAATGAGATAGAAGATGTCATAACAGCAAATGTTCATGTATTCTCTTCAATTTTTGCTCAATATGCAGGAAAGTTTTTAGGTGTATCTTGTGAACTGACATACATCAAACAGGCTGGAGATACCAACAAACGCTTTTATCCGGTTATTGACGGAAAAGTACGGTTTTACGAAGAAGAAATGTCAGAGTCACAACGATTCTTTGTAGACCATTCCTTCAGAATGAGTATTCTTACATTCTTCTATAGGACTCCATCTTTCTATATAGTTGAGACTCCTGATAGTAGTTTGGATATATCATACGAAAGGAATGCAGCAAGTGTTTTTACTGAATTTCTAAAAAAGCCCAACTCATTAATTATAACATCAAATCTGAATAATAGTTTGTTCATAGAACATTTATTGAATCAGAAAGACATTGAACTTGGAATTGTTGGTTTATTGGAGATCGCAAAACAATCTACCATACAAAACACGAATGAGCAGTTAAAATCAATCTATCAACATATTAAAACCAGATTGGAATCATGTTAGAAAAGAATTTGATAAGAGCGAATGAAGATATAGTAACCGTCACAACCATAGCCAAAAGTATGGGTTGGGGGGCAGTCTCGGAACAATCTTTCCATCGGATATTGTATTTGGCCCAAATTCTCTATTCATTCAAACATGAAGGAGAAAACATATTCTCATATTACCATTTTACGGTAACGACTTTTGGGCCATATTCAGATTTGATACAACGAAGTTTAGTCTTTTTGAAAAGTCCTTCTATATTACGTGAAGAAGAAGGAGGTTTGATTTTAAACTCTAAGAAAGAGTTTCCTTTGAATAAAGATAAAGTCGAATGGTTGAAAACTGTCATGTATATGTTAGGCAAGTACGGCGAGAAACGGCTGTTTGGCTTTATTGTAAATGACCCTTCCTATGAGAATGCCACACAGACCAACAATATAGATGGCATTGATACTTCATCGCCTGATAGCGAAACTCTTAAAGTTCTGAAAGATTTTAAGGTGGCATTTGAACAGTCTATTGAAGACACATCGGCTATTAGTGATGAGAAATACATTGAGCTGTATTTTGAATACATTTTTAGTGAAATCATAAAGTAGCAGGTTATGAAAACAAGATTCAGCCAAAATGCGAACTTTAAGGATTTGCTAAAGCGTAATCAGAATGCAATAGTCAGTGCAGCATTGAACGGTTTAGAAGCGAATGACAATTTTAAGCTAATTCTTTCCCTCATAAAAGCAATGTGCGATAAATATAAGGATAACAGCTTTAAATATATTGTCATATCAGAAGAAGATTTAAAGAATCTCACAAATAATGCAGACAGTGCAATCGAACTGTTGTTTACTGCCCCATCGTTTATTCAGAATCGTCACATTATCATTGATTCTAATTTCAATATTAAAGAAGTCAATAACGACCTGTACAATAATAACAATGAAACAAGACGTATGTTTACACAAATGTCAAAGGATGATGATGTTGTTATATTCATGGTGTCACCAGAAGGCATTATTAATTATTTTGTCAACGGCCGCGATGGTGGAGATTCTATTTTTTACGAAAGTTCTACTTTGCATTCATTCATCAGCAAAAAGCCTATTTCTGAATTGAAGAACGTATTAGAAGAATATCGAAAGCGATTGAAAATCAGAGATACATATTCTAAATTTTTTGTAGAAAAAAGTCATTTAAGGTCTCTAAGAACCGATTTAAAATCAGTACTTAGTGAAGAACAGTTTATCAAAGCCAATAAGCAATTACTAAGAAATACCCCAGAAGATTGTTTCAGAGACGACCTACGTCTGTATTTGAAAGAAAAACTCAACATCTTCTTTGTACCCAAAGAAGGCATGCTGGAAAATTTAAAGAGGTTAGACATTGTTATGCTTGATGAAGATGGTCAGGGGCTATACTTTATAGAAGTCAAGTGGGTAGGTACCAGCATTCACCCCTTAGGTAAAAAAATAGGTATAACATACGATGCAAAACCGCGTATCGTACCCGACGCATTCAAACAATCCACGGCATACATAAATGAGCTATTAACTGAAAACATCGATATAAAATTAGGGTATTTAGCTGTGTTTGATGCTAGGAATGAAGACCTCCCCGACACAGGAAAAGAGATGTCTATCGACCTGATACCTGAAGAACACAGGACTGCATATAGCAGGCATATCAAATTAGATGATTTTAGGGTAATAAACGAACATCCAAATTAATTGCTGACACCTATGTACAGAGAATACAAATTCATAGATTGCACAGAAAAATACCATTCAGTTATGCAATTTGACAAAAACAAGAATGTTTTTGTACATCGGTGGTATCCTTTTGTAGAAGGATATTCCAAGGAATTTATTGAAGACATCTTAGGAGAATTACCTTTCGTACCAACCTGCGCATTAGAACCCTTCTGTGGTAGCGGAACAACTCCTGTAGAACTGCAGAACCACGGCATAAAGTGCTATTCCTTTGAAGTCAGTCCTTTCATGCATCTCCTATCAATAGTCAAATTAGTTAGAAAGTATAATGTGGATACCTTTGAACATTATGTTAAGGCTGTAACAAAGAAACTATCCTATACAAACCGGAATATACGCAGAATAGAATCATTACCTTTTGGTGATACGATTGTAAAAAGGGATCAGAGTAAGAAATGGAATTTTCACGCCCCTGCTATAGATGGCATCCTTGATATAAGACATGCCATTAGAACGATTGTTGACAATGATGATTATAAGAATTTATTTACAATCGCATTGGCTTCAATCATCATTCAAGCAAGCAATATGTTTCGTAATGGTAAGTGCTTGTCTTACAAGAAAGGATGGGAAACTAGAATCTTTAGCAGAAAAGAGATTCATAATTTTTTTCTAGACAAATTAAATTCAATTTTTGCAGAAGATATTAGAATTATATCCAAACAGAATCCATCTGTACATAATTCTGAGATATGCTATTTAGGCGATGTTAGAAAGCATATAAACCAAGTGCCCGATGGGAAAGTAGACCTAATTATAACATCACCTCCATATCTCAATTCTAGAGATTACACGGATATTTATATGTTAGAGCTAAAAGTTTTACAACTAATCAACTCTCATGAAGAACTTCGTGAATTGCGTAAACATACATTGCGTTCTCATGTTCAAATACCTTATGATAAAATACTTCCGATAGAAAATGAAAGGCTTAGAAATAGCCTTTTAGAGATGTCAAATAAAGAATTAAACACATGGAATTCAGATATCATTAATATGATATGCGCCTATTTTGAAGATATACAATTTTTATTTTCAGAATTTGCCAAAAAGATGCACAAAGGTGGAGTCATATATTTCAATGTGGCTAATTCCGCTTATTATGGAGTTGAAATCCCAGTTGATTACATCATTGCTGATATAGCGGAATCTTGTGGATTTAAAGTCCGTGAAATAAGAAAAGCTCGGGATTTAAAAACTAGTCCTCAGCAGAGTGATAAAATTGGAAAACTTAGAGAAAGTGTAATAATCATTGACTACTAATGATTTACTTTCAAGTCTATTTGAATATAAACTTGGAAGTAAAGTTGACAATCTTTACATAGGTCTTATCATTGATTCCATAAATGAGATCTCTTCTTTGGTTAGATGTATTTTACATAGAGCTACTCATCTATTTCATGTCTGTTTTTACTCTAATCAATATCGCTTAATGAAATATCTTCTATTTATTTCTTTTGTTGCGTTCTTCAAGCAATTTGGCATTTTTCTTAATTTTAGCAGATACAGAGGAAATGATTTAGCAACTTGTTTTCTGCAGATGAGATACAATACTTTTTGCAAAGTAAAACCTATTGCTAAGGTAGTCCTATCTACAGAGAAAGACGAAACTTTCTCTAATTTTTTTTCTGAAAGTTGTTCATACGGAAAATCTTTTGTGAGACCTTTGCACGGCGATTGGTGTGTATTTTATTTGTTAATTCATTGTATAATAGGGAGTTATTTTGTATATTTGAGTATTAAAAACAGCATAATATTCCTCCTATGGCATACCAATCCAAGAATACCGATGAGCATGTAACATTTGCAGACGCACTCCTTTCAAAGCGTTATCGCAAAGCACAAAACGACTTCCTCAATCAGGTTGACGCGCTTATCGATTGGCGTCCGATCAGGACGCTGATCAACAAGAAATACACGAAGCGACAAAATGCCATCGGCGCCCCGGCTTATGACGTGATTCTCTTATTCAAGATGTTGCTTCCGAAGACATGGTACAACGATTGTGCTTTGGAGGAGCGCATCAATGATTCAATCACCTTTCCCCGATTCTTGGGGCTGAAGATGGAAGAGGTATCTCCCGACCACAGCACCATCAGTCGATTTCGTTCGGCACTGACAGAGTTGGGGCTCATGGACAAACTATTGGCGCAGTTTAACAAACAACTTTCCCGCCATCACATTTCGGTCAGGGAAGGGGTGCTTGTCGATGCAAGCCTTGTGGAGACGCCGCATAAACCCAACGGAACCATTACGATTGAAGTCGCAGACGACAGGCAAGACAATCGGAGCGAGGCGGAAAAAGAGGCAGAGGAGGATTATCAAAAACAGGTTGTCCGTCAACGTAAAGGGACGGATGAAGAAGCCCGTTGGGTGTACAAACAAAAGCGTTATCACTACGGATACAAAAAGCATTGTCTGACCAATGTTCAAGGCATTGTTCAAAAGGTGATAACGACTGCAGCGAACCGCAGTGACACGAAGGAGTTTATTGCGCTATTGCAGGGTGCAAACATACCTCAAGGCACAGCCGTCTTGGCGGACAAAGGATATGCTTGCGGGGAAAATCGTTCCTACCTGCAAACCCATCACCTTCAAGACGGCATTATGCACAAGGCACAACGCAACAGGGCATTGACCGAGGAAGAGAAGCAAGGAAACAAAGCAATCGGTCCGATACGGAGCACCATCGAACGCACCTTTGGCAGTATTCGGCGGTGGTTTCATGGCGGACGATGTCGATACCGGGGACTTGCCAAGACCCATACTCAAAACATTCTTGAAAGCATCGCCTTTAATTTATACAGAACCCCGGGGATAATTATGTCCTCATCCGTAGGATAAGGCATACCCACCCTTGAGGAGCTCGTGCAAGCAGCTCCTCAAGGGGGGATTTACAACTACTTTCACTCCTTACTGCCACCCCTTTCACTCGCTCCTTTTATGCGAAGAACTCCTCTTTACTCCATCTCCTTATTTTTCAAAGGTCTCAACCAATGAAACGATGAAAAGAAAATGGATCGATGCGCTGTGGGTGATGGGAGTATTGCTCATGGCCGGGTTTTGTTTATCTGCTTGTAATCGGGAGCTGGACGTGCAGACGGTTTTTCCGTTTGAAGTAAGCACGATGCCGGTTCCCAAACAAATCAAACAGGGCGAAACCGTGGAAGTGCGCTGTTCCCTCGTTTCGGAAGGTGATTTTTCCGGAACGTGCTATACAATGCGATTTTTTCAAACGGAGGGGAAAGGTGTTTTGCGGATCGGACGCGGGGTTGCTCTCAAACCCAATGACCGTTATCCGGTGGGTAAGGGAGACTTCCGCCTCTACTATACCTCGCAAAGCAAAGAGCGGCAGTCGCTCGAAATCGTCTTCGAGGACAATCATGGACAATCGCAAACGATCGTTCTGGATTTTAATCACAAAGAATCGGACGAGGATAAAGAGCGAGAAGCCGGTTACCGCACCTGACGGCTCCAATAATTCCTTTTTTGTTCTTAATCAATCGAAGGCGCCCGTCTGAGAGGATAGGCGCTTTCCGTTTTCCGGAAAAGCGTAAATCAGTACACCGGATTGCACCTTATAATCTTCCATCCGGAGCTGCTTCTCCTTCATTGATTCTCCATTGGGAAACGTTATTTCGAACGTTTCTTCATCATATTCGTACAATGCCGTGGATGGAATTACATATACGGCTTCCGGTGCATTACGGGACCATCCGAAACCGAAAAGATAAAACAGATGCTTGACAGGGTATCTTGTCTTGTTGGTACGGAAATATTTCTCATATTTCTCGGCATCGCTCTTGGGAATAAAGAAACTTACTGTGCTGCGCCATTTGCATTCTACGGCGATAATATCTCCGGAGACATAACTGGAACTCTTATTGGAGATACACTCCAATAGTAAATCCGGAGCTGAGGAAGATACGGGACGGTATCCGTTGACGTACTTATCCCCGCGCCACTCCAATAACCTCCAGAATGGAAGATGTTCTCCTGTGCCCGGCATACCGTCTTTGCTGATATTGGAGTGCATCACAACCCATTCTTCGAAGCGGTCGCCATAATATTTATGCTTTGTTCTCTCTTTGAAATACTGGAAGGCTTCCTTGAGTTCACCGATAATCCGATTCAATATCTCCATCATACATTTAATAAAATGCGACGTATGTGGTTTTAGTCTATTCGTTGCCTTTGCCGAAACGCTTATCTACCTCTTCGCTGATGGCTCTGCGAAAGCTCAGAGGATCGGCGATGTAATGATAGGTGTTGGTAGCACCTCCGGTAGTTACGACCACCGTTCCGAAGTTGAAAATTCGTCCCCAGAACGATTCTCCGAAAGCGATGGCCTCGGCTTTGTTCAGTTGCAATTCGACAACGCTGCGACGAATCAAGCCTAATTTGAAAATCACCCGTTTGTTGGTTACGACGTATTCGGCATAGCGCCGGCCGAGGTAGCTGTTGATAATCCCCCATACGGCTATAGCGATCAGCACATAACCCGGAATCTTGATGTAGAGTGATGAAAAGGATATCAACAGAAGTCCGAACAACAGGAATTTCATCGGATAAACAAAAACCCACCAATGCACTTGGGCTTTGTATGTAACGGTTTCACCCGTCAGCAATGTTTTGTCTATGTAGCTCATAACTAATTACAAGTTTACAGTATCAATAAACTTATAGCGTCCAAAGATATGGGTTCGGTATGTTTTTACCCAATGAATTGCAATGTTTTTTATCTAGTCACTCCTTAACAATTGATTTTTTTGAATAAAAAGGAATAAAAGTATATTTTTTCCATTGGCAGAAACCAGTGAAAAATAGAACGCAAAAGATTTTCCTTAATCTTTTCGAGCATTTTCTTTAGATTCCAAGCTGTTGCTGCCATGTAGGCATTAATATGTATCCCTTTTTCGCCCCACAGATAGTTCTGTTCCATACGGAAGTCTTTTTTCAGATGTCCGAAGATAGGTTCAATACCTGCTCTGGTTCTAAATTTCTTGCGTTTCTGCATTTTCTGATATTCACTGTCAGATTTTTTAGGTTTGTCGGGAGTAATGATTTTTACTCCTTTTATTTCTCTGCGACCTCTCCCTCCTCTGTCGTACGCAAGTTCTTGAGGTAATTTCAAATCATTGTCTTCCATCTGTCTAAGAAGCGGTTCTATGGTGTCTCCGTCATAAGGATTGTCTAAGAATGTCTGTACGGCTGTAATGATTTTTCTGCCTTTCTTGCCTGTAGTAATGAGTCCGACTTTGTTCCCAAACTCATACTGTTTGTGTGCCTTACCTTTGGCTATGCAGCGGGTAAAGGGTTTGTGCAGACTGTAAATTTTATCCTTGTCATTTCGTTTTTGATTTACAGCTTGTTTAAGAAGCGAAAACTCGTTTTCGTACAGTCTCTTCTGTGCTTCGTTCATTTTGCGGTCAAGTTCACGCAACAAGGCATTGGCAATTGTTTTCAACCGCCTTTTGGCTTTATTGGCTTTTTTGACACGCTTGGGATGTTTTCCGTTGTAAGCGTTGCGAACCAATTGTTTGCTTTCCCGGGTGTACCGCTGACGCCGGATGATTCCTTCTTTCTTAGCAATCTTATTGCATTGATCAATTACTTTCTTGCACAGCTTGGCATCCGTGGGAAAAGTGATGTTGTTTTCCTGCACGGTGGTGTCCGATAGGACAAACTTGGATTCTTTAGGCACTTCTTTGCCGTGCAGACGGACACTGTAAGCAAAAATCTTTCCTATCCCTTCTTCACCCACACGGTTACGGAAATGAACGAAATCACTCGGATCGAAAGGAAACTCATGCTCAAAAAATTCACCTCCGCAGAAATACTGAAAGTAAACATCTCGAACCCAAAACTCACGAATACGCTCATCTCCAAGATTGTATAGATGCTTTAACATTAAGCAACCAACCATCAGGCGGATGGGTACGCTCGGAGCTCCTCTGTCGGAATAAAGTGGAGCAAACTCCTTTTCAAAATAGGACCAGTCTATTTTGTCTGCAAGAACTGCAAGTTCGTGCTTCATGTCAATAAAATCTTTCAGCATGGGTCGGAACAAATCCCGCTGCCCTTTTTCCGGTAATTTTCCTAACATAATTCGCAGGGTTTTATACCGTAAAGATACAAATTCCTGCAAATATATGCAACCGTTTTTGATATTATTTTATTGAATCACAAAATATTAAGCGAATATTAAGGAGCGACTATCTATTCTCTTCTTTTCGTCGCAACGACCCGGGCGACCGTCTGCCATGTTCCGTTTTCATTTTGTTGCTCTTTGCGCCAATGAAAAGCGGTGGCAGTCATATCGGAAAAAACATATCTCATTTTGCCGGTCGTGTTTTCGGTCAATACGATGTCATCCCCCGTTTTACGGGCTAACCGGATGGCTTCGCCCGTACAACCGTAGAAAATATCCCATGCCGAAGTCTTCGGGTTGAAAATGCGGAGTGTAGTTCCGTATTCGGCATCCGGCTGTTTGTTTATCAACCTCTCGGCACGCGACGGGACGATGAACAAATCCTGAATGGCAGTGCCGTCCAAAACCCAAGAGAATATCCATTCGCCTTTTACCCGTCTGGGTGTTGCGTCGTACAAACGGTCTGTCCATTCGATCTCCCATTCTCCCACCAAAGAACCGAAGAAATCGAGCTCTTCGGGGATTCGTCCACTTCTTTTTTCGCTGCAGAGAGCAGTGCTAAATTCTTTTATCAGATTCATTTCGATAATGATTTGGAAGCAATCGGAGTAGGTCAAGTATTCATTTATGCCCGATAACACAGATACGATTGCCCTGCGTAAATACGGAGGTCTGTGTAAACCCTGCTTTCGTCATGTTCTCAACGATTTCGTCCGGGGTATAAATTTTCATATCCAAGAGTGAAATCCATCGCTCGTTTCCTGCCTCGGAAGCCATTTCGTTGCAGACGGCAAATCTGCCGCCCGGCTTGAGCACACGCCTTACTTCTTTGAAATCCTCGACGATGTCCGGCCAGAAATAGATGGTTTCAAAAGCTGTTGCAAGATCGAAAGTCGCAGATTCATAAGGAAGGGATGAGACCAAGGCCTTCATGATTTCCGCCCGGCCGTCTCGGACAGCTTTCCTGTTCCTGGCAACGGACTTTGCCACGCTCTGCGCCGAGTAGTCCGCTCCGCATACTTTTCCTTTCGTCCTTGTCAGAAAGTTGGCGATGTTTTGCCCGCCGCCGCAACCGATGTCGAGAATATCCTCCTCATCGGACGGCCGGATACATTCGTCGATGCACCAGAGAGCCATTTTATTATGGCCGTAGTTCATCCCCGCAAGCATCATTTTTCCCCAGAAATTGTTTTCAGGTCTGCGGCAATTGCTTATGAACTTCTTGAACAGTCTCATCTTCTATTCAGTTGCTAAAAGAACAAGAAATAACGAGGAGTCTTGGCCTTGTATTCGCGGTATTCCTCTCCGTAGGTTTCCTCACAATAGCGTTCTTCTCCCAGTATGAGGAAATGTGTGGCAATGATGAAGGGTATCATGACGAGTAGTATCCACAACGAGGCGGAAGCGATACAAACGCCGAACATTCCCGTAAAAAAGAAAAAGTACATCGGATTGCGCGACCAACGATAGACTCCTCCTTTGATGGTCTTTCCGGCAGGAGTTGCCACATAGTTGTGAAAAGCCCGGACAAAGAGCACCAGCGAAAGCACGTAAACCGCCATTCCCGCAAGAAACCATGCCGTACCGAACTTGAACGGGACGAAAACGGAAAGCACCAATATGGCAATTTGCAGGATTGTACTGACAGAGGCGTTCGCCTTGTCTTTGGCCGTGTACCACGAGGTGTCCACCGCGCGCTTTCCTCCCTCACGGAAGATTGCCATGTATATAAACTGTATCAGCACCATGCCGAACGAAGGTATCCATGCGTTCAGCCATCCGGCTTGCAACGTAGTGAAAAATGAAAAATCACTCATAGTCATCGGGGATGATATTGTTTTTTTAATGTGATCAGCGATACGGCAAAAATCAGGGTATACACCAGATTGTTCCATCCGCCCGCTATCAACAGAAGAAACGGTTGCGGCAGCGTTTTCCAAAGGAAATTGAGCCAGATGGTGATCAACGGTGTTGCGAAAACTATCCAACGAGGAAAAGAAGTCTGCTTTTGCAGCACCAATACAGAAAAGAGCAACCATCCGATTCCCATTAAGAAAAAAGAAAAACCGCCCAACCAGCCGATATAGGAGAGAAAATGGTCTATGATTTCGGGATGTCCCTGCGACGATACGATGCCGAAAGCCGGGAAGAAGGCATGATAAGCACCTCCGACAATTATACTTACGGATAGGGAAGCAAGCATCCAGCAGGCTGTTTTTCGTCGCGCTTTCTTAACCCTGAGAAACAAATGATAGAATCCGATGATGTACAGAACCGCCGCCAACGGGCCTATTATCCCTCCGGCAATGAGACGCTCCAAGGGCACTGCGCCCATAGAAAGCAGCAGATCTTTTTCCCGATCGGGAATGGGTTGTGTCGTAAAATACAGCAACATGTCGCCGGTATACATCAGCAGGCTACCTGCCACTCCCACATACCCTGTCAATCTGAGTTTTTTATCCATACTTTTTTCTTATTATTTGAGTTTACAAAAATATACAAGTAGAATATCGTTTGCAATCGCCAATAGTGGCTATTTTCACAGTCCGGAATCCCTATTTCTTAGGGTTTGTCGATTCGTCAATCAGTAACTCATATCCTCAAAATTCAACCTTTAATAATCTGTTTGGCATTGGCTCTCTGCCGGATTGCGACCCATCGCATGAAGGGATTTTGATGTGTCGGGACGACCTGTCATCTGCATTAGGACGACCTGTCATCTGCATTAGGACGACCTGTTGTTTGTTTTAGGTCGACCTAATCGTTCAATTAGGTCGACCTAAACGGCGTGTAAGGACGACCTAAACGGCCCGTAAGGTCGACCTAACATTCATGTAAGGTCGACCTGACTTTCTGCCGGGGTCTTTTTGCACATTGTCAGCCTTCGATACGGACTGCGATAAATTACGTATCGGCACTCCGGGGTCGAAGACAACAGGTGGAAGATTTGAAGACGGAAAAGATGCTCCGGAAAACAGTATCCTTCATGTAGTTTTCTACTGTTTTCAGGTTCTCTTTGTTCTCTGTGGAGCAGAAGAACAAATTGGTGCATATATTAGCCATAACCTCTGATATTTATGGGTTCAAATTATTGGTGATTTCCTTTCCCTTGTCATCGAAGACCTCTATGGTCGGACGACCTCCGTTTTCTTCGGGAGAAAGATTCTCGGAGGTATCCAATAGCGTTTCTCCTTCAACGAAAATGACCTGTTCTTCATCGTCATGGTTCATCACGTCTTCGCCTTGCCAAGATTTTATAATGGCTACTGCCTGTTCATAATTTTCAGCTTTCACCTGAAATTTTGTTCGCATCCGGCAAATAACCTTGCTGTCCTGATAAAAATCGAATGTATTCATATCCTTGTTGTTTATAGAGTTATTAAAAGAGTGAGCAGAAAAGCAATCCCAATAGAGCTATGATACATAGCCACCTGACAAGCGTGAAAAAGACATAGAGTGCCGTACGGACGAGAAAGCGCACGAAGTACAGGGCGGTGAGCAGGGTAAGTACCGTTATCGCTTCTTCTGTGATAAGCATGGAACAAATACAGACCGTTCCGATTATGAAAGCAGCTACTACCGTCAGCCGTATAAGGATTGTTTTCATCGTTGTTTTCGTTTATGCAATTTGTTCATATAAAGCCTCTCCATTACAGAAAGAGCCTGTTTTAGTGAGTTCCCGATAGCCATAATCCGTTTTGATTTTGTCGATTATCTTATCGGCTTCGGGCTTTTCCAATGCGAATAAATATGCCTGTAAAGCATCGTAAGCAGTATAATTCTTCCAATCTTCGCCTATTTTCCTTGCCAATTCTCTGACTTTCTCATAATCGGGATGATATGCTTTGAAATCACGCATAATCGTGTCGGTGGCATCTTCATCATATCCATCGCAAAAAGTTATGTTGTTCAAATAGCTGTCATCTTGAATGTAGTCGATACACCCACCCGAATAGTAGGCTGAAGTAATGACTATATCAAGCGTATAAAAGGAAGCACGGTATTCATCCAGATAATAGCTCGGATAATTGCGGTTGCATCCCTGCACATATTCCTTGTGTTCGGGAACATTCCCTGATTCATAGTCTTCGTCTTCGACATGGATGAGACGATTCTCGTAAGCGAAATTATGGGTTGCCATAACTGTTTATTGTTTTGTCAGGGTTAGAAAATGTTTCTCTATGGCTGCATTCAGCAGTGCATCATCGTCGTATTCGTCCTGAGAGAGGCTGATGCTTTCCGCATCTTTGTCATAGCAGGTTTCTGCGACATAATTTTCCCAACTGTACAGGCGTACATATCCGTTTCCCTTATTCACCGAAACCACAGGCACGGTCTTAAATCCGACATGGCACAACAGCAGTTCGGTCAATTCACAGGCACGATTTCCGTATTCGCTTGCCACGATAAGAATGGACACGTCCGAACCCGTTTTTATGCGGTAATGCGAGGAGGAGTTATTTCGTTTCCTGCGATCCATTGAGTGATTTAATCTTTCTTGTTCCATAATGCTGACATTTTTTTTGCGTCTAAAGCTCGGAGTGTGCCGATTTCGTTTCGTGGGCTGTTCAAGGTGGCCGGAGGGTATATGTCAAGGCTTCCCGAAAAAATACGACTTGGAACGAAGTGGAAATGTGGAGATTTTTTCAGGCGAACCCGAAAGGGCTTCAGGCCTTGACACTTTACCCGAAGGCCGGTTTCCTTCGCCCAAAGAAAGGAATCGGCACTCCGGGATCGAAGACAACAGGTGGAAGATTTGAAGACGGAAAAGATACTCCCGAAACTCTCCGGAAAAGGAAAAGGGACAGCCCCGTGTGTGAAGCTATCCCTTAAAAGAGAGGTTGTCGAGAAGAGATTGATCGGGCTAACGGAGAATGTCCTTTAGCAAATCATGCTCTTCCATGACCGTAGCGATCGTTCCGGTCAGTTCGGTATAGAGCCGGTCATATTCCGGCTTTTCATCGAAGTCGTCTCCCGGATGGTAACGGTCGAAGGTGTCTTTGACTTCTTTGTGCTCCAACAGAAGCAAAGAGAGTTTCCCCGACAGTTCGGCGGGAACTTCGTTTGCAAATTCGTTATCGATGATTTGTTCGATAAACTGATACGGCGAAAAATGCAGTCCTCTAAGCAATACTTCCATGGCCATGCTTTCGGCTATGCCGATGGGATTGTCTTGCAGGAAGGCTTCTTCGTACGTTTTTGCAGCAGCTTCGGAACGTTCACGGATAAACGTTTCGTCACTGAGCAACTGCGGATGGTAGTCTTTCAGATAAACTTCCAGCCTGAGTCGGTAATACGACAAGGTTTTCTTTTCCTGTTTCATCTTCTTTCCTTTTTAATTATTGGTGATCATTTCTCTTGCTTGGGAATGATAAAGCCGACGGGATTACGAGGCTTTTCCGCTTTTTCTTTTTGCTCCAACAGCTCCGTCAGGGCCGTGTACAACTCACTGAACTGCACATTACAGCTTACTTCAAGGTCTTCGATACGCTTTTTGAGTTCTTCATAACCGGCAATCATCCGACGCATGGCAACGAAAGTCCGCATGATGGCAATGTTCACTTCTATTGCTGTCGGACTGCGCAGCACCGATGATAGCATGGCTACTCCCTGCTCGGTAAAAGCCATCGGAGCAACGGAGCTGTGTTTGAGGGTTTCGGGTAACCGGTCACAATTTGTGACCAGTTCCGTCCATTCGTTTTCGGTAAGTTCGAACATAAAATCTTCCGGGAAGCGCTGCAAATTTCTCCTGACGGCCTGTTTGAGCACTTTTGTCTGCACACCGTAGAGTTCGGCCAAATGATAATCCAATATCACTCTGTTGCCACGAATCTCAAGAATTTTATTCCGGATGACGCTTACATCTGCTGTTATTGTATTCATATCATTGATTTATAGAATTTGTATTCAATTTCAAGTCATTGTTTTGCTTGTGACACCGGAGATCTGAATATATCCAGCTTATCCGATAGCTTGAGCATGTCCTGTTCTATCTTTTTATTGGTGATACGGGCGTAAATCTGCGTCGTTTTGATATTGGTGTGTCCCAGCATCTTCGACACGGATTCGATGGGAACGCCTTTGCTCAAAGACATCGTGGCAAATGTGTGCCGGGCCATATGAAAGGAAAGGGGTTTGCGGATATTGCACAAATCGGCTATCTCTTTCAGATAGGCATTCATCTTCTGATTGGAGAGAATCGGCAAGAGATGACCGTTTTTCCGGACAGGAGCATATTTCTCGATAATCCTCTTGGGGATGTCGAGCAGGATGATATTGGTGGCTACCCTTGTTTTCTGGCGTCTGGTCATGATCCATTCACGTCCGTCCAATTCAACGATGTTATCCTCGGTTAAATTGGACACATCAATATACGCCAGGCCACTGAAACAGGAGAATATGAAAATATCGCGAACCAAATCCAATCTGGGTATGGATATTTCTTTTCCAATGATTCGCTGAATTTCTTCATCGGTTAGAAACCCTCTGTTGGAATCTTGCGTATGAAACCGCTTGTTCACAAAGGGGTCATGAGACAGAAATCCATGTCTGCGCCCATAAAGAGTAATGGTTTTGAAAAGCTTCAAGATTTTGGTTGCCGTATTCGGACAACAATGAGCTACAGTCAGCAGATATATCTCAAAGTTATGAATGACCAACGGGGTAAGCTCCGAGAATTTGAGATCTGTTCTGTTGTACTTCGCTTTGAGGAATCGGGTAAAATGCCGTTTGCTGTTTTCGTATTTTTGTAAAGTGGCAGCCGTTTTATTGATTCCCACCTGGGCCCGGACATCCTCGTTATGTTTATCGAAAAGTTCCATTATACTGTTTAATGTATCCGTCTGTCCGCAGTATTCCGATTTGATTCTCTCCGGCGTCAAATCATCTACCGTTACTTCCAAACGTTTGTAAATGGTCAGAATATCAGCCCTGATTTCTTCGATCTTTCGATTGACTTCAAGTGCTTCTGCACTATGTCCTTTGACTTTTTCTTTTTCTGAATCCCATAATTGGGCATTGACAGACAGGCCTGTAGACCCCAGCGACAAACGCTCCTTATTCAGATAAATCCGAATGAGGATGGGCGTCTTACCTTCTTTGTTGATGTAATTGCTGCGCAAGTAAAAAACTGAACGAAATTGACTCTTCATTTTGCTCCAAAATTAGTGTAACCATACGGCTACAAAGTTCGACATATGATTTTGAAACAGAGTAATTTGTCAATCGTCTAAATATCGTCTTAACGTCGTCTGTGGTTACAATTTTCAGCCCCTTTGTTTTTTGTAACCAAAATGGAACCACCGGAGGCATATTTACGGAATATAAGCTTATTCCGAACCTCGTCCGACGTGTGGGGTGGCGACAAAGAAAAAGCGCCTTAATTCGTTGGAATTAAGACGCTTTTGGATTCGTTTCTAAAATTGCTTCAGATGACCTATAGCCTATCTTTCAGCTATTTAGCGGTATGGACGGGACTCGAACCCGCGACCCCCTGCGTGACAGGCAGGTATTCTAACCAGCTGAACTACCACACCGTTGCGAATGAATTTACCTCTTTCAGCGCTGCAAAGATAAGTTTTTTCCTCAATATGCAATAGTCATCAAAAAATCTGCACATTCCACTCACCAGTGCAACATTGAGTAGCTAAGTTAGTTCTAAAACTTGGCATGGCGTTAGATACCCTAGCCCTTTTCGAGGTCTTCGATTAAGTTTGTCTTGTATTCTTCCACAATGTGGAGATGTAACTTATGTTTTTTAGGTATTAGGATGTCAATAACAGTTTGGCAAGGGATAGATCGAGAGGAGTAGTCAATTTGATATTTTCGATATTACCGACAATCAATGCCACCGGTCGGCCAAAATGGTGTTCATATACCGAACAATCATCGGTAAAATACTCTTCATAGGGTTGCCGATAGGCCTCTCGAAGCCATTCGCTCCGAAAGGTCTGTGGAGTTTGTACCGTGACGTACCGACTCCTGTCCACTGCATAATTGCCATCAGTGGCATAATAGCGAAGCGATTCGGTCATAGGGCGACAAGGAGCGACAGCCCCCTTCAACTCTGCAAGATCGAAACAGGCATCGATAGTTTCAGCACTGACCAAAGGACGTACCCCGTCATGAACAGCAACCAAAACACCATCAGGGACAACCTGCAATCCATTCCGAACAGAGGCGAAACGTGTATTTCCACCTGCAACCACTCGATGAGAGACCGAAAAGTCATACTTCCGGCACAATTCCTGCCAATAAGCATGATGATCTGTGGGCAATACCAATACAATAGCATCGACATGAGGGGCAAAGCGATTCAGCGTATGCATCAGCACCGGTAGACCGGCCAAAAGCAAAAACTGTTTTGGCCGATCGGCCCCCATACGTAGCCCATGACCACCGGCTACGATCAGAGCATAGCGTTTTTGCTTCATGAGAGTTTGGCCATGAGTTCTTCGATCTGCTTGTCGGCTACTGTCAGTTTCTCACGACAGAAACCAATCAGAGCAATAGCCTCTTCGGCCAGCTTGGTCAGCTCGTCCACATCCGGGCTTTCATGTTCGATGACACGAACGATTTCTTCGAGGCGTCTCATGGCCTCCGTATAAGTCTTATTCTCACTCATAATAATGGCAAAAATAAGGATTTGCAGAAGAAACCGTAAACGAATCCTCCGGATCAAACTCTAAAAACAGATGAGAAATACTAGAAGTAGCCGAATGAGTAAAAAAACTCGCCCCTAAGGGAGGAGGTTTCCGTTTTTGTGAACTCACCCCAATAAATCCAAAGATCAATTCCGTATTGCAGAACCATCTAACCTGTCTTTCGGCCCCTATATTTCGATCTCACCACAAGAAAAAACTAAAAAAATATATCATCACGGCATTAACATAAAAGCCCACTATCATGTTTTTAACAAAAAACTATTATTATTGTAGTAGACAAATACAAACACTATTATGATTAATATACATACGCGACTAACTATCCTGACATTTCTTGGATGTGTCTTTATGCTCTCAGCCAAAGAGATTAATGTAGATTCTCTTTTCCAAATAGCGGCTGACCGGACTCTTTCTGCCACGGAAAAGAAAAAAAGGTATGAGGAGATGGGCAAACAGCTCGAACTGCATCAACAAGTCGGTAGTGCAGCCGATGCATATTCCTTAGCCATCAAGTTCTGCCGTGATGGTGGCTCGACCGAAGAGCTTCCATATCTGCTTTTAAAGTATGCAACTATGGCGACTCATGCAGGTCGTTATAGCAATGCAATAACGGCTCTAGAAGAAATAATGAGGCTGCTTAAAGACAAAAACGACAACATTATATTAGCCCGTACTTATATGCAAATAGGCATCGTATTTTTCTTTCAGGAAAAATGGGATGACGCATTGGTATTCTATGAACGTGCGCTACAAATCGCTCAAAAGAAAAAGGAGGAAAGAGGTATCTCTATAGCCTACAACAACATGGCTAACATTTATCAAAAAAAAGGAAATACTCAAGAAGCCTACTCCTATTATAACAAAGCTTTGGATATACAACGAGCCAATGGTGATAGTGTAAGTATGTGCAACAGTCTCATGAATATCGGAACAATTATGATCAATGAGAAAAATCCGGAGGATAGCTATAAGATTTTGAAAGAAGCTCTTACAATAGCATCCAAAATAAATGATATCGAGATCCAGGCCCTATCTTATGCACATCTTGCATATTATTATGCATGGAGAAGCGAATACGGCAAAGCAAATGAAGTGCTCACAATCGCAGAAAATTTGGCATGCCATGCCGGGTATAATCAAACCAGATTGGCAATATTGGATATAGCCAGTTCCATATATGCCGAATACGGCTTGTACTCTTTGGCTTATGAATGCCAAAAAAGATCCAAACTTCTGGCAGACTCTATTGCCGCCAAACAGATGCAAGAAAAAATTACGGAGTTTGACATTCGGTTCAAAAGCAAAGAGAAAGAGGCCGAAATAGCACTGAAAAACCAGGAATTACATCTGGCTCGCAAATTACATATTGCCCTTATCATAATATCCACACTGATGGTGGCAACCATCATTACCCTTATCATCCATGCAGCAAAGAGATATAGACAAAATAAGAGACTGCGAGAAATGAATGACACCAGAAACAGACTCCTCTCCATTATCTCACACGACATCAAGGGCCCCGCTATAGCACAGAAAATGGCCCTCGACACTATACTATCATCTTCATCTGACTGCGGCTCTATGACTCGGAATATGCTTTCTTCAATACGCAATAGTGTAGCAACAGAATTGGCTCTTTTACAGAATTTACTCGACTGGTCTAATATCCAAATCGGGAATTTAGCTCCCAAATTTGTAGTTTTCAACATTGTGGAAAACATTGGAAAGGTGATCAATTTATACTCTATTTCTGCTCGGAATAAAGATATTAGTTTACATTTGGAAGCTCCCAAACAATGTTTGGTTCATGCTGACCAACAAATGATCAATACCGTAATACGCAATTTACTCAGTAATGCAATCAAATTCTCTAAAGCAGGAAGCGTAATACACATCCGTGTGGAAGAAAAAGAGAAAGCCATGGGGATCAAAGTGTCTGTATCAGACAAAGGTATTGGCATGAGCAAAAAACAAATAACCGATATCCTCGAATCGGATAAAAATAAGAAGGCTACAGCCGGGACCGATGGGGAAATAGGTAGCGGATTAGGTTTAATTATCTGCAAAGGTCTGCTCAAAAAAAACAAAAGCAAGTTATGCATTGACAGCAAGGAAGGTAAAGGCTCCGTATTCTCTTTTGTCCTTGCCTCAGCGTAAAGATTACACAATATGATTAGTATCGTACTCGTGGATGACCACGAACTCTATCGGGTAGGTTTGCGTGCTGCCATTAGTCAAATGCAAGGTTTGGCAGAAATCGTAGGTGAATGTAGTTCTTGTGAAGAACTGGAAACGTTTCTGAAAGAACAAAAAGAACCGGGACTAATCATACTGGATATTTGGCTTCCCGATGGGAATGGAGTGAATATTGCTCGTAAGCTAAAGAAGCTATATCCGGCTGTTAAGATTATCATACTGTCTTCCGAAGTATCAGAGAAAACAGTCAATGAACTATTGGCGATTGATGTGGAAGGATACATATGCAAAACAGCTCAGATCAATGATATAGGAAATGCCATCCGCACAGTAACCACGGGTAGCCATTTCTATGGCAAAAGTGTTTCGAAGATGATACTGGATATTTGCGTATCACGTTCCGCAGACCAATCGCATAAGAAAAGCAAAAAACAGCAACAGCAGCAGAACGACTCTTCCGAGCTGACCCAACGAGAGAAAGAAGTAGTACAATATCTGTGCGATGGCTATTCTGCCAAAGAAACAGCCGAAAAAATGCACCTTAGTTACCGAACGGTAGAAACACACCGTAGTAATATTCTGCACAAACTGGGATTCACCAATGCAGCCGAACTGATACGGTATGCCGTAAAGAGCGGATTAGTGGATTGGCAATAGCTCTCTTTTCGGCTACCTGACGGCTCAAGAGAAGACAAGTAAATCGGATATTGGAGGCAAGAAGAGAAGAAACGTTTTCGATCAACCATTACATATCGTATATTTATTCGGACAGGACATTTGTATATCACAGCCAAACGCGTACCTTTGTGCGACCGAAAAGAAATAAATAATTATTCCATAATATGGCTAAAAAAGAAAATCAACAACCGGACAACCACGTAGGAGAAGTGGTTTCACGCTCAGAGCAGTTCATAGAAAAGAACATGACCAAAATCGGCTTGGTTATTCTGGGCGTTTTTATCATTGTGGCAGGTATTTTTGCCTACAAACGTTTCGTCAGCGAACCTAAAGCTCGTGAAGCTGCTGCCAAGGTATACCTTGCCGAAGACAAATTCATTCAGGAATTGGACAGCGCAGCCTTAAATGGAAACGGTGCAAACGAAATGGGACTGTTGGCAGTAATAAAAAAATACTCCGGCTCGGATGCATCCAATCTGGCAAAAGCCTATGCCGGCATTTGCTACTACAACCTCGGAGAATATCAGAAAGCCATTGATCATCTGAAGGGATTCTCCTCCAAGGAAAATATGGTAGCACCATCTATCACTCGTCTTATCGGTGACTGTTATGTACAGCTCAAAAAATATGAAGAGGCCGTAGGCTATTTTGAGAAAGCTGCGGCCGCAGCCTCTAACGATGCCATTACACCGGGCTGTCTCATCAAAGCCGGTCGCGTATACGAAGAGCTCAAACAATACGACAAGGCTCTCGCCGCTTATAAGCAGGTAAAAGAAAAATACTACACATCGATGGAAGCTAATACGGTAGAAGCAGATATCATACGTGTAAAATCCAAAGGAGCGAAATAATTGTATCAAAACGATAAAAAGAAAGGCATCTATCTCATGCTGGGATGGATGCCTTTTTTCAGGACAAAACTTATCAGACAATTACAGAATCATGGCTACAGCTTATCATAACTTATCCGACTACGACTACGAGAGCGTTCCCTGCGGCAAAGACTTACGTATAGGAATTGCTGTTGCTGAATGGAATCGCAATATCACAGAGCCACTGATGAAAGGGGCTATCGATACCCTTTTGGAACATGGTGTATCGGCTGACAATATCATCGTACAGCATGTTCCCGGCACTTTCGAACTTACCTATGCAAGCGCATACCTTGCCGAACAGCATGAAGTAGATGCAGTGATCGCTATCGGCTGTGTAGTCAGAGGCGACACCCCCCACTTCGACTATATCTGCCAAGGGGTAACACAGGGAATCACCCAGTTGAACATTGACGGCTTTGTACCAGTCATTTTCGGAGTCCTTACCACGGAAACAATGCTTCAGGCCGAAGAGCGTGCCGGGGGCAAGCATGGCAACAAAGGCACGGAAGCAGCCGTTACAGCTCTTAAAATGGCAGGATTGGAAAGAATATAAATTCCGGCTTTTTTTCATTCAGATTGCCTAATCCTAATACTACATCATCAGGAAACACTTTTGTAGAATGCAGCAAATTCTACAATGCCCCATAGGGCGACCACAGCAAAAAACTCTCATAATTCGGAATATCACCTTCAATGAAAAAAAGTTTTCTTTTAGCCATAGTAATGCTCTTTGGCATTGCCATGCAGGGACATTCTGCTCCGGTTACGAAAGAGCGAGCTTTGAATCTGGCTCGGCTGGCTTTGCGACAGATATCCTTGCGAATGGGACAAACAGCAGTATCTGACAAGATTTCCATCGATTACGTCTATCGGCAAGGAGATGCCGAGAGGGGTATCACATCACAAGAGGAAGGCTCTCCTGCATATTTTTATGTAGCTAATCGTGGAAATAATGAGGGCTATGCTCTTGTAGCAGCAGATGACAGAATACCGACAATTTTGGCCTATTCACCCATTGGCCGTTTCGACATGGACAGTATGCCGGATAATCTTCGCATGTGGCTACAAATTTACGATCAGGAAATAGGCCTGATACTTTCCGGAAAAGCTCAGCTCAATGAAGAGATATTACGCACCGAGGGCGTACCCGCTGAAGTACATGCTCTGATGGATAACGGTCATTTTGCCAACGATCCCATGCGATGGAATCAAGGTTACCCATGGAACAATAAGGAACCACTGCTTCCTAATGGCAATCATGCCTATACCGGCTGTGTTGCTACTGCTGCAGCACAAATCATGCGCTACCATAGCTGGCCGCTTCAAGGTGAAGGCTCTTTCGATTATCATGCAGGTTCATTAGTTGGCAACTGGTCCGGCACATTTGGTGAAATGTACGACTGGATCAATATGCCCGGAAATCCCGACCTTGATAATCTGACTCAATCTCAAGTGGATGCCTACGCCACACTGATGCGTGATGTGAGTGCATCTGTTTCGATGAGTTTTTATGAAAATGGAAGTGGTACGTACAGCGTTTATGTAGTAGGAGCTTTGCGAAACAACTTTCGCTACAAGCGTTCACTGCAGCTACATGTACGCGCCTTATATACCTCACAGGAGTGGCACGATATGATCCGCGGGGAACTTGCCTCCGGAAGGCCGGTCTATTATGCAGGGAATAACCAGAGCATAGGACATGCTTTCGTTTGCGATGGTTATGCTTCGGATGGTACTTTCCATTTCAACTGGGGTTGGGGAGGTGTTTCCAACGGCTTCTACAAACTAACACTCCTCTCGCCGACTTCGTTGGGTATCGGAGGTGAGGGAATAGGTTTCACCATTTATCAAGAGATCATCACCGGTATCGAACCGGCTAAGACTCCCGCTGAAGCCGGTACAGATGCCTTGCCGATCTTGGCACTGAAAGATATAGAAGCCGAGTATAAAAGTGAATCCGGATTGAACGTAGAGTATTCGATATATAATACAGGTGAAGAGCAATCAAATCTTGACCTCGGATACAGATTGAACAAGGCTGACGGAGAAGTCATAGAGGTGAAAACTTCATCTAACAATATCTCTTGGTACGGATACGGAGAGCATCCCGAGAGTTTCTCATTGGCACCTAATCAGTTGTCACAAGGAATCAACACCATCACCCTACTTTATCGTCGCACAGGCACCGAACAGTGGGAGCCGGTACGGCATGCACAGGGAGGATATGTCAATAGCATTAAAGTAAATACGACAGACCCGAACAATGTCGTAGTCACGGTAGATAATAACGAAGGCAAGCTCAGTATCGTCCCCAACAGCTTTGTCGCAGATCTGAATTCTTATGAACATAGTACGATTACAGTACAGTTCAACAGCGACAGCCCTGATGAGATCCGTACACCCGTAGCCTTTGCTCTATCTACAGGAGCTACTGCGGACGATGCAATATCTTTGGGCTGGGTAATGGCTGAAGTTCCGGGCGGTAGCAGCAACTATCCGGTGGTTTGGTCTAAAGACGTTCTCACTCTCTCGGAAGGCGACTATACATTGTGGTATAGATTTTCCATCAACAACCAAAAGGATGAATGGAAAAAGATCGGAAGCGTGTCAGTAAAAACACCGACAGAGTATACGCACCCCTTATTCGAAGTAGGCCATAATCAAACTTCTACCTATACGCTGGATATGGCACACAACAGAGTATTGCCCGACTTTACACTCAAAAATCTCGGATTGCCTTTCAATGGTGAGTTGGTTGTTGTTTTCCGCCAAACACAATCCTCATCGGGGTCTTTATGGGCAGCCCAAGAAACAGTACATATCAAGCAAGGAGAAACTTTCGTATATAAACCTGTTGTCGAAGGCCCTATACCCGATGGATCCTATCGTGCAACCCTCCATGCATTCGTAAACGGACAACCACAGTTGTACCTCAAGGGGAAAAGGAACTACACGGTGAAGATCGTCAATGGTACAGCAGTAGAAGCAATAGAATCGTCAGAAGAGATCAGAGTATTCCCTAATCCGGCACACGATTATGTGGAAATATCGGCACCTTGCATTCCCCAAGAAACATCTATCATTCTTTTCGATCTGTCAGGTAAGATTGTCATGAAGAATAGTTTATCAGCAGGGCATGGTAGAATGGATGTCAGCCGACTTCCTAATGGGACCTACATCCTTAAGATGGATGGATATACGACGAAAATAAATATAGTGCACTAAGAAAACTCAACGACCAAATAAAATGGGAGAGCGTATGCAGGAAATATATTTTCCACATACGCTCTCTTCTTTTTGATAGACCCGGGGAGCACGTAATAAGGACAATGACTTTCATCCCTTTTTATCGTAAAAAGAGACCTTTGCGCAATAACCCTCCCCCCTCATATTGATGAAGACAAACACAAGCATTGATTTGACGAAGAGAGGAGTGCTTCATGTAGGTCTCTGCGAACCTCAAGTATATACCTGAAGGAAACTTGGGGAAATCTCCGTTTACTTGGCAGCCATACACCTGCTCATTGGTCTTTCACTGAGATACAAAGAATGAACTTCCACGAGAGGATACTATGGTCTTATACGAGAGGATACTATGGTCTCACATGAGAGGATACTATGGTCTCATACGAGAGGATACTATGGTCTCACATGAGAGGATACTATGGTCTCCTACGAGAGGATACTATGGTCTCACATGAGAGGATACTATGGTCTCCTATGAGAGGATACTATGGTCTCACATGAGAGGATACTATGGTCTCACATGAGAGGATACTATGGTCTCACATGAGAGGATACTATGGTCTCATATGAGAGGATACTATGGTCTCACATGAGAGGATACTATGGTCTCACACGAGAGGATACTATGGTCTATTGATGGAAGATGCTATCTGCTCTGTGTCGGATGGCAGGTTCGGGGAGTGGGAGGTTCCGTGTGAGCTGTAAAACCGATAGATGAGATTGTCGCATGGCATTTTCCGGGAGATTTCATTGTCAATTGACTGATTTTTCAGTGTCATTATAGATATGAATACCTCTAAAGCTCCTCCATGACTTGTGCGATACACTCTATAGGTGAGCAAAAACGATACCGAAAAGATACTTCTTGATGACCTTCTCTTTTTGCAAAGGGCTCAAAAAGCAAGAAAACAGGTTTATTATATTTCATATTGATGATTTCTTCTAATTTTACGGGCGGTTATCGGGTTGGAGGTGAAAAACCGAAGGTAAATTCCTCCATGGATATTTCGCAAAAAGATCGGCCCATGTCCCTCTTTATTATTTCCCCGAGATCTTATCATATGTTCAGGAACATATTCATAACATCATAAAACATATCAAACAATGAAAAAGCTTTTACAGGCTAAAGCCTTGATTCTGGCATTGGGACTCTTCCAACTGCCCGCAATCGCCCAAACGCAAATGCAAGCAGACCGAACAAACGGTCAATTTGCAACAGAAGAGATGCAACGAGCATTCCAGGAAACGAATCCCCCTGCAGGTCCTGTGCGTGCTATCGCTGAGTACGAACGCTCTGCAGCCGTTTTGGTACGCTATCCGTTCGGTATCCCGATGGAATTGATCAAAGAGCTGGCCAAGAACGACAAGGTGATTACCATTGTGGCGAGTGAAAGCCAAAAAAACACCGTTATAACCCAGTACACCCAAAGCGGTGTGAATCTCTCTAATTGCGATTTCATCATTGCGAAAACGGACTCTTACTGGACACGCGACTATACCGGTTGGTTCGCAATGTACGATACGAACAAAGTAGGTCTCGTGGACTTTATTTATAACCGCCCTCGTCCTAACGATGATGAATTCCCCAAATACGAAGCACAATATCTGGGCATCGAGATGTTCGGGATGAAGCTCAAGCAGACCGGTGGCAATTACATGACGGACGGATATGGATCCGCTGTGCAGTCACATATCGCATATACGGAGAACTCCTCTCTGTCTCAAGCTCAAGTAAATCAAAAGATGAAAGACTATCTCGGCATCACACATCATGATGTGGTACAAGATCCGAACGGCGAATATATCAACCATGTGGACTGTTGGGGCAAGTATTTGGCGCCGAACAAAATCCTCATCAGGAAAGTACCTGACAATCACCCTCAGCACCAAGCTCTGGAAGATATGGCAGCCTACTTCGCAGCACAGACCTGCGCATGGGGAACGAAGTACGAGGTGTATCGCGCTTTGGCCACCGATGAACAACCGTACACGAACTCTCTGATTCTGAACAACAGGGTATTTGTTCCTGTCAATGGCCCCGCCTCCGTGGATAACGATGCTCTGAACGTCTATAAGACGGCAATGCCCGGTTACGAAATTATAGGTGTCAAAGGGGCTTCAGGAACACCTTGGTTAGGCACAGATGCCCTGCATTGTCGTACTCACGAGGTAGCGGATAAGGGCTATCTCTATATCAAGCACTACCCGATACTGGGCGAACAGGCAGGCCCTGATTATAAGATCGAAGCGGATGTCGTCTCATGCGCCAATGCTACTATCTCGCCGGTACAATGTTACTATCGTATCAATGGTTCCGGTAGCTTTAAGGCTGCTGATATGACGATGGAATCAACAGGTCACTATACTTATAGCTTTGCAGGTCTTAACAAGAATGATAAGGTAGAATACTATATCTCTGCCGCTGACAATAGTGGTCGCAAAGAGACTTATCCCTTTATCGGCGAACCTGATCCTTTCAAGTTTACGTGTATGAACGAAACCAATACATGTACTGTGACCGGAGCAGCCAAAGCTCTTCGTGCATGGTTCAACGCCGGTCGTTCAGAACTGGCTGTTTCGGTAAGTTTGAATATTGCCGGCACATATCGGATAAAGCTTTATAACACCGCAGGAGAAGAAGTCGCTGCAATGACCAAGGAATTAGTAGCAGGGACGAGTGTCTTCAGTATGGATGTATATTCTCAGGCTCCGGGCACATATGTTTTGGTTGTTGAAGGAAATGGAATCCGTGAGACAATGAAAATTCTCAAATAAGGGGTCTTATTTGAGAATACTCCTCAGGTAGACATAAAAAGGCTGTGTGGATTTTTCCTCCACACAGCCTTTTTCACATCGTATTATTTTCTCCACTGTGATATTCTTAATTCGGGTTATTATTCAAAATCTGAGCATTGGTTTCGTAAATTTGCTCTTGCGGACAAACTGATAGAAGCAATCAAACAACAAGTTCGACAGTCATCAATTCTAAGAAGTAGCAAATGCTCAAAACATTCCAAATGAAATCAGAAATGAAATCACAAAGGAGAACTCTAACGACCGATTGGGGTTTAAGACAATATCTTCTATTTCTTCTCTTTGCAATTCTCGGGCAGAGCCTTTCTGCACAAGATCGGGGTGCAATAGATATCATCAAGAAAGCTGAGAGACAGACGAAAAGTCGTATCGGCGTGGAGATACGTCGCTGTCGGGACGATAGCCTTTTCGTATCAAATCGAAGAGACGAACAGTTTTGTCCGGCATCTCTGGTTAAGCTCGTAACCTCTGCTTCCATTTTGCGTCTGAGGGGAACCGAGATACCATTCTATACCGGAGTCGGCATGGATGGAAAAATTCGAAAAGGGATTCTTGACGGTAATCTCATCATCAAAGGAGGAGGAGATCCTTCTCTCGCATCCAACTATTTACCGACGGACTCCGGTCGATTTGCCTATGCTTTGGTCGATGCCGTCAAGCAATGGGGCATAAAAGAAATAACAGGAGATATCATCGTCGATGCATCAGCTTTTGACATTGAGGGAGTCAATGACAGTTGGCTCGATGAAGACAAAGGCAACTATTTCGGTGCCGGCGTCTATGGATTTAACATCAATGATAATAGAATAGATGTCATCCTTGCTACAGGCAAAGCAGGCTCCGAAGCTCATATCCTGAGAATAGAGCCTCCTCATCCGGAGGTTCGGTGGGAAAACAGAATCGAGGTAATTCACCGAGGAAAGGATACTGCCGGATGCTATGGCGAAGGGTTGGATCTTAAGCGAACCCTTACGGGAGTCCTTCCGACAAATATCGTTTCCTACCGCCTCAAGACGGATTTGCCCGATCCTGCTCTATACGCAGCTGCATGGGCCAAAGGCTTATTGTCTGCTGCCGGCACTCTGTGCCAAGGGAAGTGCCGTGCCTCATATCAAGCCGTACCGATCACTCAAGAATTATTAATCTACGAATCCCTTCCATTGGATTCATTGGTGCGGGTGATGAATTTCCGTAGTCTGAACCATTTTGCAGAGGCTTTTGTCAAACAGTTGGCTCCCCTTGCATCGAAGAATCATCGGGGTAATACAACAGAGCGAGGTCTGTCCGTCATCCGAAACTATTGGACTTCCCAAACAGGATTGCAGCATACCGACATTTCTCTTTCGGATGGATCCGGTCTCTCCCGTAAAAATCGCTTTAGCCCGAATGCCCTCAGCCAAATACTGATCGATATGATCAGTCGCGGCGATCTTGTTACCACTTCGTTCTTGAATAGCCTGCCTCTCGCAGGAAGAGAGGGTACGGTGAAGAACTTCATGAAAGACGAAGCAATAGAGGCATACCTCAAGAGTGGTAGTATGAAAGGTGTTTTAGGGTATGCCGGCTATGTGCGATTCCAAGGAGAATGGTACAGCGTTGTTTTGATGGGTAATGATTTTTCTTCTTCCGCACCGGTTCGTCGTGCTTTCTCGGATTTTCTTCTCTCTTTCTTCTCTTCCGCTATCTCTACTAAGCAAGTCCTGCTAAAGGAAAAGTAAACAGCAGCTTATTTCGTCTCATTCCTCTTACCAGATCTCGTGCCAATTTTATGTAGGGATGATTGCCGACAACAAGCATATATATAGCTCTCTATAGGTATTCATTCGCATTTAAGTCGCACCTCGAGACTACTTTTCTCGAATGCTTATTACTCATAATCTCTTCAAAAACCTCGTAAAATCGGAGAAAATCAATAAGTTAACTCTATTCAATAGAAATGCAGTAGAAAATTTGCATACCTACATGTTGGTATATTCGGTTTTCTTTCTACCTTTGTTTCACAAAAGTGATACGATAAACAAAATTTGTCTTACCATAAAACTATTACAAAACTATGGCTTACGTTATTAATGACAGTTGTGTAGCATGCGGATCATGCATCGATGAATGTCCGGTATCAGCTATCTCTGAAGGTAGCATCTATAAAATCGATGCTGATACATGTATTGATTGTGGCACTTGTGCTGCAGCATGCCCTTCTGAAGCTATCCATCCTGCCGAATAATTTCAGGTTAGGTTAGAAACAGGGACAGATACGGCCGCTCTTTCATAGGAAGGGGTGGCCTTTTTGTATATGGATATGTTGGAAAACAAGCAAATCGGCAGGATATTTATCGAAGGCAGGTATAAATCCTAATCAGTCATGCTCCTAAACGGTGTTGAACCAAGATGAAATTAACCGCCCCTGACTACCATCTTTTTTTCGGCACACGACAATACTCTTTTAACGCGTAATAAAACTACTAGTGGTTTCAGAGAAAACTACTAGTGGTTTCGGGCAAAACTACTAGTAGTTTCGGAAGAATCTACTAGTAGTTTCAACGGAATCTACCGGTGGTTTCCGAAAGAAGCGATAAAAGTGCCGAAAGGGAGGTATAAATGCCCGTCCTATTTCATCCTCTTTGAGAGAAGTTACGTCTCTTTACAGGATGGCCGAAAGGCTATACCAGACTAAGACCAAGACGCATTCGAAGCTCATCAAAAAGAGGATTTTCCTGATTGAGGCGTTCGATCTTTTCGTCCAAAGAGACAGGCACTCGGTTCAGAGATGTAGATTCGGATACTCGCACATTCATTCGTATCGTCGTATTGCACAGCTTATCCGCAAGGAAGCCCAGCAAACGAGCCGATACGTTATTGATTTCTTCCTCTTGCCTGCTATTGAGCACCTCCACTTCAAAAGCCGAAGTTCCGGGACGGAGTTTAGGAAGACAGTTAACCATCGTTTCTTTCAGGTGAATCTCCTCCGAGAGCTTCGTTTCGGCAAATTCGATCCAAGCCAGTTGCAACTGCTCCTCATCGAATGATTCGGTCATCTCTGTCCGAACCTCCTGAATGTTATTTTGGAGTTGTTCCTGTTTATTGCGGATTCCCCTTAATGTAAACCGGCCTTCCGATCCGACAGTAGATGTTGCCATCGGGCGCGTCGGAGGTACCACTTTCGTCTGTTCGGGCTTGTCTTCCGTGATAGTTGGAGCAGTGGTCTCGGGTTGGCGTCGCTGCTCCCCGATACTCGGCTGAGGTGGGACAGAGGACTGTGATGGAGCAACGGATGGCTGCTCTTTGGCCGGAGCCGGCCGGGGAGATACCGATCCGCTCACCGCGGGATTTGCATGCTGTGCTCCATGGGTCGGAGGCGGAGCAGTCAGTCCCTTGCTAAATAAAGCCGCGATATTCATCAGCGACAACTCCAACAACAGACGCTTGCCATTGCTCTGGCGATACTGCTGGTCACAGGCATTCAGTATCTTGAGCGATTGGTATAAGAAAGAAGTCGGGCAACGTGCTGCCATATCCACATATCGCTGTATGACTACTTCGGACTGCTCCAACAGCGGCAAGGTAGAAGCGTCCTGAGCCATCATCAAATCGCGGAAGAAAGAAGCCAATCCGCTCACGATCACCTGTCCGTCGAATCCCTTGGCAAGCAATTCGTCCAACACAATCAATACGGATCGGTAATCCCCCTGTAAAAAGAAATCCGTCAGACGGAAATAATAATCGTAGTCGAGGATATTCAGATTCTCTATCGTATTGGCATAGGTAATATTGCCTTCCGAAAAGCGGGCAATGCGGTCGAAGAGCGAAAGAGCATCGCGCATCCCTCCATCGGCTTTTGTCGCTATTATAGCCAAAGCTTCGGCTTCGGCTTTTATCCCCTCGCTGTCTGCTACGTAGCGCAAATGTTGCTCTATTCGGGCCGGTGGTATTCGTTTGAAGTCGAATATCTGACAGCGCGAGAGAATAGTGGGCAGGATCTTGTGCTTCTCTGTGGTAGCCAATATAAAGATCACATAAGAAGGCGGTTCTTCGAGAGTCTTCAGGAAAGCATTGAAGGCTTGCTGCGAGAGCATGTGTACCTCGTCGATGATGTAGATCTTGTATTTTCCTATCTGTGGCGGCACATTGGCCTGCTCTATCAAGAGACGAATATCATCTACCGAATTGTTCGAAGCGGCATCCAGTTCATATATATTCATGGATCGCTGCTCATCGAAAGCCTTGCACGACTCGCATCGCCCACAAGCTTCTCCATCCGGCAACCGCTCCAGACAGTTGATGGCACGGGCGAAGATGCGTGCACAAGAGGTCTTTCCCACCCCACGCGGGCCACAAAAGAGATAGGCGTGAGCTGTCTTTTGCTGTACGATGGAGCTTTTGAGTGTAGCGGACAATGCCTCCTGACCGACCATCGAGGCAAAAGAATCGGGGCGATATTTGAGTGCAGATACGATGTATTTCGTTTCCATGAGCCGAGCCTGTTTGCTTAGGAAACAAAGGTAAACTAAAAAGAAGCAGCAGAGGCTATGCCGGAGAGCGAACTCTCGCGACATAGCCTCACGATGCTTTCAGTGAAAAAAAACGTACAATATCAATGCAAGGCACAACCCTTACACTTCTCTCTTATCTGAGTAAAGAAATCATTGCCCTTGTCATCTACCAGAATAAAGGCCGGGAAGTCCTCCACTTCGATCTTCCAAATAGCCTCCATACCCAGCTCGGGATATTCCAGACACTCCACTTTCCTAATGCTGTCCTGAGCCAGAATGGCTGCAGGGCCTCCAACACTGCCGAGGTAGAATCCGCCGTACTTCTTACACGCATCCGTCACTTGCTGAGAGCGGTTGCCTTTGGCTATCATCACCATACTGCCTCCATGCGATTGGAAGAGATCCACATAGCTATCCATACGGCCCGCTGTCGTAGGCCCGAACGAACCGCTCGGCATCCCCTTCGGGGTTTTGGCCGGACCGGCGTAGTAGATGGGATGATTCTTGATATAGTCGGGCAAACCCTCGCCACGGTCGATACGTTCTTTTAGTTTGGCGTGAGCAATATCACGCCCCACGATAATCGTACCACTGAGAGACAAACGGGTGGAAACAGGATACTGCGACAGCTCTTTCAGAATCTCAGGCATCGGACGATTCAGATCGACCTTGACCACCGTACCCTCTGTACCCTCACGCATGGATTCAGGGATGAGGCGTGTGGGATTGGTCTCCATCTTTTCGATCCAGATACCGTCTTTATTGATCTTTGCCTTGATATTGCGGTCTGCCGAACAACTGACGCCCATACCTACGGGACAGCTTGCTCCATGTCGGGGCAGGCGGATGATGCGCACGTCGTGTGCGAAGTATTTGCCTCCAAACTGAGCACCCAGTCCCAGACGATAGGCAGCTTCCAAGACTTCTTTTTCCAGTTCGACATCGCGGAAGGCTCGCCCGCCTTCGTTGCCCGAAGTAGGCAGATTGTCGTAGTACTTGGCCGAAGCCAGCTTGACGGTCTTGAGGTTCGTTTCGGCCGAAGTTCCGCCTATCACGAATGCGATGTGATACGGAGGACAGGCAGCTGTACCGAGAGAACTCATCTTATCCACGAGGAAGTTCACCAGTGTCTTGGGGTTGAGCAGTGCTTTCGTTTCCTGATAGAGATACGTCTTATTGGCCGACCCTCCTCCTTTGGCTATGCAGAGAAAGTCGTACTCCATGCCGTCCACGGCCATCAGGTCGATCTGTGCCGGCAGGTTGCACCCCGTATTCACCTCCTTATACATATCCAAAGGAGCATTCTGTGAATAGCGCAGGTTCTCCTGCGTATAGGTATCATAGACACCATGCGAGAGCTGCTCTTCGTCATGACCGCCCGTCCAGACCTGCTGTCCCTTCTTACCGAGGATGATAGCCGTGCCCGTATCTTGGCAGAAAGGGAGCTGTCCCTTGGCTGAAACCTCCGCATTGCGCAGGAAAGTCAGAGCCACGAATTTGTCGTTTTCGCTGGCTTCCGGATCGGACAGAATCCGAGCCACTTGCTGCTGATGCTCCGGTCGCAAATAGAAAGCGATGTCATGAAAAGCCGTCCGCGCAAGTAATCGCAGAGCTTCCGGCTCCACTTTCAGGACATCATGATCGCCAAACTTGTCCACGGACACATACTCCTTCGTCAGCAAATAATACTCTGTCGTATCATCCCCCATAGGGAAAGGCTTCTGATACTTAAATTCTGGAGTTGCCATAGTAATTGTAACTATTGTTATTAAAGTGATAATCGGTTCTTTTTCGGTCTCCCATCGAGGACATTTCCTTATCGATGCATTTGGAGTATTTCCTCTGCGGAGGCATTTGCTATTTCCCTGAGACAAGGCAGACAGAGACAGTCATGATAATGTCGTCGAAGGAATTCGAAGTGATGCGATTGCAGTTGTACCGTCCTACAGTCGCATCGCATATCGGGAAGATCATGACCGCACAGAAAGCCTCTCCCACAACGGGGACAGACTTTCCGGCGGTAGTTTCCCGATAGATTCAGGCTCATATCTCAGTGGGCATCCCGGCCAATGATCGCTTGTATCCATCCACCAGATCAACCATGATCTCGGCCACCGTCTCCGCATGACTTATCTGCGATACTGCTTGGCCTATCTCCAATTCGCCCTCGTGCAGGTCGCCTTCGAAAATACCTTGCTTGGCACGACCACGACCGAGCAGCTCGCGCAGCTCTTCCACGGAAGCACCGCGCTGCTCGGCAGCGAATACATCCTGATAGAATTTGTTCTTCAGCAGTCGCGTAGGCGATACAGCCTTGAGCGAAAGCATCGTATCTCCCTCCACCGACCGGCGGCAATGTGCCTTAAAGTCTTCATGCGCCGAACTTTCCTCACTCAGAGCAAAACGGGTCCCCACTTGTACGGCATCGGCACCCAAAGCCAAAGCAGCGGCAACTGCACGGCCGGAAGCAATCCCTCCGGCAGCAACCACAGGAATGTTCACAGCATCCACTACTTCAGGTATCAAACAGAGGGTCGTAGTCTCCTCTCGTCCATTATGTCCGCCGGCTTCGAACCCTTCGGCCACGATGGCATCTACACCGGCTGCCTCTGATTTGCGAGCGAATGTGGCACTGCTCACTACATGTATCACCTTGCTACCGGCAGCTTTCAACTTGGGTGTCCACACCTTTGGACTACCGGCTGACGTTACCACTACGGGCACATGTTCCCTCATGATAATCTCCATGATTTTGTCCATCTCCGGATAGAGAAGAGGCACGTTCACACCGAAAGGCTTGTCTGTAGCAGCTTTACACGAACGGATGTGATGCTCCAGATTGTCCGGATGCATGGATCCGGCACCAATAAGTCCCAAACCACCGCAGTTGCTCACAGCAGAAGCCAGTTTCCAACCGCTGCACCACACCATGCCTCCCGATATGATCGGATGTTCGATACCCAATAATTCGCAAATTCTATTCATTTCTTATTCTTCTTATTTTGTATTGTATCTGTTATTCATTTCTCATTTGGTCGTCTGATCCGATCCTTCTTCAAGGCATCTTAATCTTATTTAGTAAGTACAATCGTACTCGCTTTTTCAAGTTTTTACGGCACACACAACATAGTCACAAAAATAGGAACAAAAGCCGACTTCTGCACCCTGCTATTTCGATGCCTATGAGAAAGAATCACCCGAACCGCCAAATCAAATGCAACAACCCCCAAGCAGAGGCCTCGACAAATTCCAAACAGCTTCGACAAAAAGTGAGAGGAAATCGAAAAATAATTTCAACACAACCTCTTTATAATTAAATCCGGCTTTCAGGAGAATCCCAAAATATAGAGGGTGAGCCAAAATTTTCATTTTGACACACCCTCTTCGTCCGTCTTATGTAGTAGGATCAGTGTAAGATCAGAAGTTTACACGAATACCGGTAGACCAAGTGCGGCCGAAACCGTACCATACGAGAGCCGAAGCCTCATCGTGTTTCTTACCGATGATGTTGTCGTCGGCATCGCTCACATATCGCTTGTCGGCTACGTTGTCCATGTTGAAATAGAATGTGGTGCTGAGTGAACCAAGCTTGAAATTGTAGGATGCAGACAGATCGAACAGACCTACATCGGGCAACTTCCATGATTCCACGATTTCTTTGCCATCCGCTTCGTACTGCTGTGCATTACGCGTTGCGGGGTTGAATCCTGCATAGTTCTTGCCAAGGAAGTTGTACTTACCTATGACATGGAAACCCTTGAACAGCTCTATGTCTGCCGATACAGCAGCCGTCATCTGTGCTGCATCTCCGACGTGAAGACCCTTGATATAGGTTATATCCTGCCCTGTCTCGTTGCCGGCTTCGTCATAAGAGGTGTAGCTTACATTGTTTTGCCAAGTCCAGTCACCGAGAGAGAACATACCGCGAAGGTCGATCTGACGAATAGGACGATAGCTGATCTCAGCCTCTACCCCACAGTGAACAGCATCAACGCCATTGAGATAAACATACTCGTTTCCGATTCTCTTCGAGGTCACGCGATCCATCCACTTCGTATAGTATCCGTTGATATTGAACTCGAAGTTTTTGTGATTCGTGAATCCATAACCGACCTCTCCTGTAAGCACCTTTTCCATATTGGCTTTGTCATTGGGAATGATAGCCCCCGCAGCATAGACATTGCCAAAGAGCGGTGCGCGTGTGAAGAAACCGCCATTGGCGAATACATTGTGTCCCTGTGCGAACTTGTAGCTCAGACCGGCCTTGCCACTCCACGGAAGGAAGCTTTTCCACGGCGATACGCCGGGCAGGTAGCCGGTGGACTTGCTACCGCCATAGTTGTGGTTGCGGTAGAGTTCGTAGTTGATAGATCCTGATACGAATGCATCGATCCATTCGGACGAATGCTCCATCTGTGCGAAGAGGCCTTGCCACATGATTTCGCCTGTGTAGTCCCGATTTACAATGTCACCCACTTTCAGTTGCTGACCTTCCGTATGGTATGCGAGCTTTGTCTTGGGATCCTCTATGTAGTAGCTACCGCCGAGCAGATCGGTGATCTTGTCATAGTGGTCGCCACGGTAGTAACGCCCATCGTATCCGGCTGTCAAAGTCAGCGAACTATTAAGTTTCTTCTTGAATGAAGAGAGTAGACCGAACCACTTGTGAGAGTTGGAACCAAGGGCAAAAATTGCTTCCGAGCCATTGCTCGCCGCAGCATTGGCAGCCAGTACGGCATCGTAGTCGATAAGTCCATCGGGAGTCACCTTTGTTTGTTCATAGGGTTGTCCGGTGTTGTAGTTGATCAATACCCACTTACTGTTTTTTCCATAAGCGCGACGACCTCCACCGGTAGCCAAAGATGCGTAGGCTGCGGTATAAAGAGAGGTATTCTCATCCATCTTCCAGAAGTGGTTCAGCGAGAACTGGGGCTTGTGGTACGTATTGTAAGCATAAGCCGTAGGAGTCAGTTCGCCTCGCAGATAGCCGAAGGATTGATTGTGACGGATGCCGTATTTGTCATAGTCGGCTACAGAATATTTGGAAGAACGTTGATTGTGCCATTGCGGTGCACCGAATCCGGTGAGAGAGAGGGTATGGCGTTCATTGAACTTCTTCGAAACGTTGAAGAAGTAAGAGAATGCACGTCCCTTCAGCCCCTTCACATAACCCAGACCCGTCATATGGGAGCCTGCAATGGTGATAGCCCAACCGTCGTTCATACCCGTAGAAATGGAGAACGATTCTTTGTGCAATCCGTCATTACCCATACCGACATAAGCCGAACCTCCGGTGTTGGCATCCGTAGTCTTCGTGATAATGTTCATCGTACCACCTACCGAGCTGATACCGAGCTTGGAGGCTCCGAGTCCGCGCTGAATCTGAATGGTACTGGCTTGATTCATCAGACCACTCCAATTGCTCCAATATACTTTTCCGTCTTCCATACCATTGACAGGAACTCCGTTGATGAGTACACCGAAGTTGTAAGTGTCGAATCCACGCACATTGGTACGACCATCACCGAAGCCTCCGCTTCCTTTTGTCGTATAGGTAGAGGGAGTGGATTTAACCAGTTCGGGAAATTCGACATTCAACGATGCTGCCTGAATATCAGCCACGCGGATATTGGACACGGGTACCGGCGTCATACGGTCTTTGGGCACCACAGAGGCTATTACCTGAATCTCATCCAAGCCGATGGCCTGGGGATCGAGGAGAATCGTACCGAGGTCTTCTTGAGAACCTCTGCCTATAGAGCGAGTTACGGTAGCATAACCTACGCAACGGAAAGTCAAGACAGACTTGGCCGGTACTTCGAATCGGAAGCCACCATCCATATCGGTGGTTACACCGCGGAGGGATGCTCCCTGACCGGTGCTTACGGATACACCGATGAGCGGTTCGGACGTTTCTGAATCGATCACCTTACCGGTCACCACTGTTTGCGCTATGGCGAGAGAGGAGCCTAATGCCAGCAGCAATGTGGTCAGGAAAAGTTGTAGAATTCTTTTTCTCATAAGACATAACAATTTAGATTCGACTTAAAGGCATCTCTGCCCAATTTTTGTACAAAGATAATCCAGAAACATTAGAGGAGTGTCTGTCGAAATTATTTTTGGTACACCCTGTGTGTTTGATCGAAAGCAGGTTTGGAACTTGCTCAAAACCAAAATAAGGCAACTGCATCAAAATACAGGCCACTCGGGGCACGGATTTTGATGCTAACGACCCGATTTTTTCAAATCTCCCGAGACTGAATATTTTCTTACATTTGTCGTCCGATGAAGCTATCTGTCGGAAGTTGGATGCCGCTGCCAAGAGAGCCGATTGCTTGAATAGAACTACATGGATAATAGACTATAACAGAACATGTGCACCGAACATCTTTATACCCCCGATTTTTCCGGCCGGTCCTTTCGCGCCCATAACCTACCACGCCATCTCGATATTTGGACAAACAGCATATATCCCTATGACGAATAAGTAGGAATAACTCCTCTTATACTTCTCCTAAAGGCATAGGCACCCGCACGGTTCGGCCACGAATCGTGCGGGTGCCTCTTTTATTTCAGCTTCCGAAAGGGCCTTTTTCGGTCTTCGATTTATATACAAATGAGTTTCGATCTATATATAAATTGAAAACGATTTATATACAAATCGCAAACGATCTATATATTTATCGTAAACAGTTTGTATATAGATCGTTATCTTGTCTCCCACAAACCATGTTTTGACCTGAAAAAGTTCGTTTCTTCATATTTTTGACTTCAAAATCCGTTCCCTTTCAGGTGCTTATTTAGAATCATTCCAAATTCCGCTTCGTTGTTGAAAACTAAAAAATTTTCAAACGCGATCGTCCTGACAGGCTGCCCCGGGGCCGACGCATTAAATCGGTTTTGCGGCTTCATTCGAGCGAGTTTCTTCTCTGAATACGAGGGATTGAGGACTTCATATTGGCCTTTAAGGGGGAAACGATATGTTGCCGGCGGTAACTGACGTGTACTAAATGGTCGTCTGACACACATAAAATGAATGAACAAAAGTGCCTGCTTATTGTGCAAAGGTCCCATTAATTCGTACTTGTTTGATAATTGGATGTAGCAATCATGAGCTTTAGATGTACGTTAGTGGCTGAAATGCGATTGCCCTGTGGAATATGCATCCTGCTATATCTGAAATGTGTTATTTTTTCTATCTTTGTGCGGACTTTGTTCAGAGCTGCCTTTTCCTATCGGGATCGGTGGTGATGATTAAAAGGGAATCGGGTGAAAATCCCGAGCAGTCCCGCTGCTGTGAACCTTGTTAAGCTTTCGGCATTTATATCCACTGTCCGTTCTGTGCGGATGGGAAGGAGTCGGAAGTATGGGGTGAGCCAGAAGACCTGCAAAGTCTTTGTCTGCGGCTTCGAGGAAAAGCCGGGAGAGAATGCACTTGTGGTCAATCCGACTTTACTGCCACAAGGATCCGTTTCTTTCCCTTTCAATCCCCCGAGGAAAATTTTGTTTCCGACGCAGCGGAAACGATCCGATTCTTTTGCCAGGAATTGGAGTGTATTGTGAGCGGACCCTTATGGTCTTGTCTTGGCGGGATGAGCTCCGTACAAGGCAGACCTAAGGGTCTTATCATTTTCTATCTTATCATTCTTTTTTATAGAGTTTCTGCTTCCCTTCGGCGAATCTACAGGGGTATGATTATCATATCGAATTATGAAATCTTATTGTTTTTCGGATGTCACGACCTAAATAAGTACTATTTTTGTGGGGTTTCGAACGAGACTTTGGTTTCCGTTAGAATTTATAAATTGATAAAACCACATGAAAATATGCGACATGTCGCCCTTCGGCTTCATTTTCTTGTCATAGGAAAAGTCTTGAGCCAAGTGAAGAAGTCGCATACTATTTGACTAACTATAAAGCTGTTTGGATGAATATGCAATGGCTTAATGACTTGCTTTTCGGTGTAGGAGTGGGGCACTCCATTCTCTTGGTCGCCGTAACGATTGCCTTAGGGATTTGGTTGGGAAAGATAAAGATCTTCGGAATTTCTTTGGGGGTTACTTTCGTTCTTTTTGTCGGAATAGTCTTAGGACATTTCGGCATGAATCTGCATCCCGACGTACATCATTTCTTCAAAGAGTTCGGACTGATCCTATTCGTTTACTCGGTGGGGATGCAAGTGGGCCCGGGTTTTTTCTCCTCTCTTCGCAAGGGGGGGCTTACCTTGAACCTACTGGCTATGGGCGTCGTCTTTTTGGGGGTACTGACAACCGTGATTCTGCACTTCGTGACAGGCATATCCATGTCCACAATGGTAGGAATTCTGTCCGGTGCCGTGACGAACACACCGGGCCTGGGAGCTGCCGAGCAGACATTCCATGATCTAACGGGAACCGGCGATCCGACTATCACACTCGGTTATGCTGTAGCTTATCCGCTCGGAGTGGTGGGGATCATTGCGTCCATGCTGATCGTACGAGCTATTTTCAAGATCAGTGTGGCCAAAGAGAAAGAGAAGATGGACAACCTGGAACATAACGATGACAATCAGGCTATTGCACTCTCTCTGGTTGTAAAAAATCCGGCCGTTTTCTCCAAAACATTAGCAGAAGTCCGCCAACTGCTCAAAGGTCATGACTACGTGATTTCGCGCACAATGGATTCGCGTACCAACAGTATTTCGCTGGCACATTCGGATACGGTTCTAAATGAAAACGACAGGGTTTTCGTAATTACCAATCCGCAAAATGCTGCGGTGATTAGCAACTTCATCGGGACTGAGGTACAGATGGATAGGAAGCAGTGGATACCTACCGAGTCGCATTTGGTGAGCCGCCGATTCATCGTCACGAAGTCCGAATTGAATGGAAAGACCCTCGGTTCATTGCAGCTACGCAAATTGCATGGCATGAATGTGACACGTGTGAACCGTGCCGGAGTTGAGATGGTAGCATTGGCTTCCCTTCCGCTACAGGTGGGCGATCGTCTGACTGTAGTGGGCAGTGAGTTGGTAATGCCCAAAGTGGAAGAACTGATCGGTAATTCTGTCAAACGACTGAACGAACCGAACCTAATGTCCATATTCATCGGCATCGGTCTCGGTATCCTTTTGGGTTCGCTTCCGATCGTTTTGCCCGGTATTCCTCAGCCCGTCAAGCTGGGACTTGCCGGTGGGCCATTGGTGGTGGCTATTCTATTGAGTCGGTTCGGTTATCGGTATAAGCTGGTGACTTATACGACTCCCAGTGCCAATTTGATGTTGAGAGAAATCGGCATCACCATATTCTTGGCTTGCGTAGGATTGGGGGCCGGAGAGGGGTTCGTCGATACGATAGTAAACAAAGGTGGTTTTACATGGATCGGATACGGTTTTATAATCACCCTCCTGCCTCTCCTTATCATCGGATTTATCGCTCGCAAAGGATATAAGATCAATTATCTTACGCTGATGGGAATGTTGGCCGGAAGTACTACAGACCCTCCTGCCCTGGCATACGCCAACAACACGACTAACCACGATGCTCCGGCCGTAGGCTACGCCACGGTCTATCCTCTGACTATGTTCTTGAGGGTGCTAACTGCACAATTGCTTATCTTATTCTTTTGCTCTTAGTCCGGCGAACCGAAAGACTCGCTTTGCGGAGCCTATCTCCGCTGTATTTGCTGTAGACTGCTTGTACATATCGCCTAATGCCAATCTGAATGATGACTGATACGCAAGACAATGAGCTTATCGTTTTCGGAGAGCATAATGTCCATGCTGAAAACCTTTCCATAGGCCATCTTGTCACATACTTTCCGTGGACGAAACTCTTCAATGCGTTAGGTATGGTAGGGGCCTACCCGGCTTTGCTTTACACAAATGAAAAAGCCGATGCTTTGTATGAAGTCGTATCGTCGCTTTTAGGCGAGTGGATAGTATCGGGAGATCCATGGATTGACCTCTCTTTGGTTTTTCACGATGTGGAGGGAGGGCAACCCGAAGGCGATTTGGAGGTTGTACTCTCCTCTCATCTAAACGAAGAAGACATTATGCCTGTACCGTCCCTCTTTTTGTATGATATGGGATGCTATCTTTTGGAGGCAGCCGCTGCATGGATAGCTGATCAAGAAGCATATGGGATGCAAACGGTGATCGAACGAAAAGATATCAGCCGCAGACCCTCGGAAAAAGGACTGCGGCTGGTAGGGCATTGGATTTTGAAGGCAATCGAATGTTAGCAGCTCTCCATCCCACAAGAGCAACCCTCGGGATCCAATTCTATTGTAGCATGTCGTATTCCGTGGGCACTGCATTTCTCCCGCACTGATTCTTTCATATCGAATACTGCTTGGGGCGAACTGAAATCGTCCGGGCAGTACACAACGTGAATCGTCATCACGTGTGACTCTCCGTCGAGTGTCCATAGGTGGATGTCGTGAACGCTACGTATATGTGGCAGAGAGAGTATATCCGTCTTTAATCCCTCTAAGTCTATCCCATCGGGTACACCTTGCAGCAAGACTTTGAAGGTCTCACGCAGGTTGCCATACACATTGTACAGGATCCATGCTGTGATACATAGAGAAAGTATCGGGTCGAGGATCGGGGCATTGACAAAGAGCATAACGATGCTGACTACAAGTACGGCTGCCCATCCGAGCACATCTTCCAGAAGGTGTAGCATCACGGCACGTTCGTTCAGCGAAGAGCTTCCTTTTAGTCTGAGTGCGGCCAAGCCATTGACTACCAATCCGAATATGGCCAGAATAAGCATCCCTCCTGCTTTGGGCTCTCCCGGCATGGAGAAACGTTGTACGGCTGCAATGATGACAAAAACGGATCCTACCAGAAGAATGATTGAAATAAGCAGTGCACCGAGCAGAGAGAAGCGTTTGTAGCCATAACTGAAAGATCTGTCGCGACCCTTTTCCGATAGTTTCTGCAGTCGCCAGGCAATGCCGAGCGAAATGGAATCACCGAAATCATGTAAGGCATCCGACAGGATGGCTACACTTCCGGTGAAAATACCGCCGACCAACTCTACGATGGCAAAGAAGAGGTTCATAGCGAAAGCAAAAAGCAAATTGCTTCCACTTTCGCCATGATGGTGATGATGGTGATGATGTCCGTGATGATGTGCCTCATGTTCATGTTTGTGTTCCGAGCAACAGGCGTGGGCGTGAGATTGTTTTGTTTCCATAGATTTGTCTCCTACACATTATGATCTGATGTTTTTGTTTTGACGGAGTGTCATAATGAGCAATTTGCTGCGTTGCTTGCGACATTCGGCTTCAGTCACGTACTTCAGTACGTTCCTTTCAGACTCTGTTTTAGCACCTTTGTGCTCCAAAAGAATTTTGACACTGCTCCATCTTTATTGCAAATGTCATCATTTTGTCGACATTTTTACCATATATTTCGCCGTTTCAAAAAGTATAACCCTTGATTTCAGGAAATTCATCATGCGACGTAAAGATCGAGAAATGAGCCGAGAATTCGGTTTGGAGGTAATTGATCGGGCAGCCTACGGTGTCCTTTCTGTCGTGGATTCGGACGGTGCACCCTATGCTTTGCCTCTTTCCATCGTGCGCGATGGGGAGAATTTGTATTTTCATTCGGCACGTGCCGGACACAAAGTCGAATTATTCACCCATGAGCCTTCGGCCACCATCGTATTTGTAGGCCGAGTGGAGGTACCCGATGTATATACTCCGGAAGTACTGGAATCGCTAAAAGAGGGAGACTCCCGCTTATCCGGCTCTATGCTGAGTCGAATTTTCACCACCGATTTCGAGAGTGCTATAGTCAAGGGGCAAGTCATTCGTGTAGCAGATCATGAGGAGTGCGTGCATGCCTTACGATTGATATGCGAGAAGTACACGCCAGAGAAAATGGATTTGTTCGATAAGGCCGTTGAAAGCGGCATGCCACATACCGCTATCTATCGCATTAAAATAGATATGATCACAGCGAAACGAAAGCTTGTTCTCCCCGACTAACCATATCAATATCTCCCTACTCAAATCTGATGTAACCCCAGGGTTATTTCATTTGAAAATTTATACTGTATCTTTATACTGTATCCTTAGCCTCTTTCTTCTATTATTCGGGACCTTTGCATAATAAGCAGGCACTTTTGTTCATTCTTTTTATTTCTGTGTCAGGCGACTATTTGGTACACACCGGTTTTCCACTGGTGGAAACTTCTTTTTCCACCGGTGGAAATTTACTCCCCTTTAATGAGTGCCCCTTTGAGACGTCCAACGACGTTACCGCCGGCAACATATCTTTTCCCTCTTAAAGGCCAATATGAAGTCCTCAATCCCTCGTATTCAGAAGAAACTCGCTCGAATGAAGCCGCAAACCAATTTAATGCGTCGGCCCCGGGGCAGCCTGTACAACCTCATCGTGTATTACAACTTCTTTTTTACCTTTGCTCACCTGTGAGTATGAATGAATCCGAATGAGAGTATCCGATCTCTGTTCCAGACTTTCATGGTTATTACCCGTAATCCTTGTCGGATTGCTCTGTGCTACTTTGGTCGCTGCGGAACGTCCTATGGCCGGAGCAGTCGGATTGCACCACCGTCGGCATGCAGCGCTGTCTGATTCTACAGCGAAAGACACGGTGCCTCTCGCAAAACCTATTCCTGACAGTGCTTTTCGAGATTCCCTTCCTGCCGATTCCACCGGATCGATGCGGCAGGATAGCGTGTATGACGATGAATTCGAATTGGAAGATATAGTGGAGTACGAAGCTACCGACTCCATCGTTTTGCTCGGACAGAATCGTGCCTATCTTTTCGGCAAGAGCTATGTGAGCTATCAAAAGAGTCGCTTGGAGGCAAACTTCATGTATCTCAATACCGACAGCAGTACGGTTTATACTCGCTATGTCCTCGATACGGCCGGTTATCCGATGGCCTTTCCTGTTTTCAAGGATGGAGAGCAGTCGTTCGAAGCCAAGAACTTTACCTACAACTTCCGCACGGAGAAGGGGATTATCAGCGGAGTGATCACGCAGCAGGGCGAAGGCTATCTGACTGCCGGTAAGACCAAGAAGATGCCCGACAATATCATGTTTATGCAAGGAGGGCGTTATACGACCTGCGACAATCACGATCATCCTCACTTCTATATCAATCTTTCCAAGGCAAAGGTGCATCCGGAGAAAGACATCGTCACCGGTCCGGTCAATCTGGTTATCGCCGATATGCCGCTGCCGATAGGTCTTCCTTTCGGCTATTTTCCCTTTTCCAACAAATACTCTTCCGGTATATTGATGCCCACGTACGGAGAGGACAATCGCTATGGATTCTATTTGAGGAATGGTGGATATTATTTTGCCTTCAGCGACTATATCGATTTGGCATTGCGTGGGGAGATCTTTTCCAAAGGGTCATGGGGCATTTCAGCCCAATCGAAATATAAGAAGAGATATAAGTACAACGGTTCGTTCGAAGCCAATTATCTGGTATCGAAGTCCGGCGACAAATATGTGCCCGGAGACTACAGCAAGACCACCAGTCTGAATATCCGATGGACACACAGTCAGGATCCGAAGGCCAATCCTTTGCAAACGTTGTCGGCCAATGTCAATTTTGCCACCGGGAGCTATTTCCAGAATTCGCTGAATACCACCTATGATGTCAATGCCCGTACTGCTACGACACGAAGTTCGGCCGTGAGCTATTCGCGCAAGTTTCCGGGTACTCCTTTTTCGATTACGGGTAGCATGGATATTAGCCAGAACATGCGCGATACGACGGTGAGCCTTACCTTGCCGAATCTTTCGATTAATATGTCCACGCGTTATCCTTTCAAGCGGAAGACCCGTGTAGGACCGGAGCGATGGTACGAGAAGTTGAGTGTGGGCTATTCCGGTCAGCTTCGCAATAGTATCTTGACAAAAGAGAAAGATTTGCTCCAGAGCAATCTCGTGCGCGATTGGAAGAATGGTATGCGTCATTCCGTACCGATCAGTTTGACTGTCCCTTTGTTGGATTATATCAATCTGACTCTGGGGGTTAACTACAATGAGTGGTGGTATACGAAAGGCATACGGAAGTCGTGGAATGAGGATAAGAAAACATTTCTGCCTTCGGACACGACCTATAAATTCCGCAGACTGTACGATTACAGCCTGTCGGCAGGCTTATCTACCACACTGTACGGTATGTTCAAGCCTTGGAAACCTTTTTCCTTCGGAGGCAATCTCATTATGATCCGTCATCGCTTCACGCCTACTGTCAGTTTCTCCTATATGCCGGACTTCACGAAACGCCGATATGGTTTTTGGGAGCATCACGAGCATACGGATCAGAACGGCAAGCTGCATACGCTGCTCTACTCTCCTTATTCCGAGCAGATATTCGGTGCTCCCTCCATGGGCAATGCAGGATCTGTCAATTTCTCTTTTGACAACAACTTAGAGGCCAAGATCAAATCCAAATCGGATTCGACAGGGATCAAGAAGATCAGCCTGATAGATCAGTTCACGTGGTCTACATCCTATAATATGTTTGCCGATTCTATCCGATGGAGCAATATCTCGGCTTCGCTGGCACTTCGCCTCTCCAAGAGCTTTACCTTGCGCTTGTCCGGTCTGTTCGATCCCTATTTGACGAAGTATTATGAAGGAGAAGATGGGAAGATCATTCCCTATAAGAGCAACGACCTGCGTATTTTTAACGGCAAGGGATTGGCACGCCTGATCAGTACGGGTACTTCTTTCAGCTATACGCTCAACAAAGAGTCGCTCAGCGGATTGATAGCTCTTTTCAGTGGCAAAAAGGAGCGGAGAGATGAAAAGAAAAACACAGGGGCTACTCCTCTTGAAGGAGACGATGCTGCCGATATACTTGAGGGAGGAAGACCGCAAAATGAAAGTGGGGGGTCGCTCCTCGAGCGCAACCGTCAGGGCGGAGCAGTGGATCAGGATGGTTACTTCGCATATTCGATCCCATGGAGCCTGTCCTTCGACTATAGTTGGAATATTGCTACCGACTACAATAGGTACAATGTCAATAAGATGGAGCACTACTATCGGGTAACGCAGAATCTGAGCTTTCGCGGCAATATCCAGCCTACACCGAACTGGAGCTTCGGATTCAATGCGAACTACAATTTCGACTTGAAGAAAATAACATCGCTTACCTGCAACGTCACTCGCGACATGCACTGCTGGGCTATCTCGGCCAGTTTCATCCCTATAGGAGCATACAAGTCCTATAATTTCGTCATATCGGTGAAGAGTTCACTCTTGCAAGATCTGAAGTATCAGCAGAGCAATCGTCCCATCACGAATACTTGGTATTGAAATAGAAAACAAGAACAATCCATAATATGAATAGCTTTAGAGAAAGGAATTATCAGTTTGCTCCACCCGTAACGCAGAACCTGATCATCATCAATGCGATATTCTTGTTCGCGACTTACGTACTTGAGGCACGATTCAATATTGATCTGAACGATACCATGGGGCTGCATTATTTTCAGGCAGACAGTTTCAATCCCATACAGTTCGTTTCCTATATGTTCTTACACGATGGCCTCTCGCATCTCTTCTTCAATATGTTTTCCCTATGGATGTTCGGACGGCTGATAGAGCAGTTTTGGGGGGCGAAGCGTTTCCTCATCTTCTATGTTATTTGTGGTCTTACGGCTGCATTGGCACAGCAGATCGTATGGGCTGTGGATCTGATGCCCATCGTGAACAGTCCGGCCGAGTTTGTTCGCTTTCCGGAGGGTACGGAGATGCTCAAGAGTGCTTTCCTCAATTTGCCAACGACGGTCGGTGCCTCCGGAGCCGTATTTGGGTTGCTATTGGCCTTCGGGATGCTCTTCCCCAATGGTGAGATCTACCTTTTCTTTATCCCCATTCCCATCAAAGCCAAGTGGTTTGTTATTATATACGGCCTTGTAGAGCTGTTCCTTGTCCTTGGTGTTGCACCGATGGCAGGTGGTAGCAACATCGCTCACTTTGCTCATTTGGGTGGTATGATAGGAGGTATTATACTCATTCTCCTCTGGCGCAGGAAAGGAGAGATCGATGGACCTTACAATTAG

Protein sequences of DBSCAN-SWA_1

>NC_015571|2083822:2135169|2093009_2093474_+|WP_013816560.1|DBSCAN-SWA
MKRKWIDALWVMGVLLMAGFCLSACNRELDVQTVFPFEVSTMPVPKQIKQGETVEVRCSLVSEGDFSGTCYTMRFFQTEGKGVLRIGRGVALKPNDRYPVGKGDFRLYYTSQSKERQSLEIVFEDNHGQSQTIVLDFNHKESDEDKEREAGYRT
>NC_015571|2083822:2135169|2089975_2091268_+|WP_013816557.1|DBSCAN-SWA
MYREYKFIDCTEKYHSVMQFDKNKNVFVHRWYPFVEGYSKEFIEDILGELPFVPTCALEPFCGSGTTPVELQNHGIKCYSFEVSPFMHLLSIVKLVRKYNVDTFEHYVKAVTKKLSYTNRNIRRIESLPFGDTIVKRDQSKKWNFHAPAIDGILDIRHAIRTIVDNDDYKNLFTIALASIIIQASNMFRNGKCLSYKKGWETRIFSRKEIHNFFLDKLNSIFAEDIRIISKQNPSVHNSEICYLGDVRKHINQVPDGKVDLIITSPPYLNSRDYTDIYMLELKVLQLINSHEELRELRKHTLRSHVQIPYDKILPIENERLRNSLLEMSNKELNTWNSDIINMICAYFEDIQFLFSEFAKKMHKGGVIYFNVANSAYYGVEIPVDYIIADIAESCGFKVREIRKARDLKTSPQQSDKIGKLRESVIIIDY
>NC_015571|2083822:2135169|2093504_2094152_-|WP_013816561.1|DBSCAN-SWA
MMEILNRIIGELKEAFQYFKERTKHKYYGDRFEEWVVMHSNISKDGMPGTGEHLPFWRLLEWRGDKYVNGYRPVSSSAPDLLLECISNKSSSYVSGDIIAVECKWRSTVSFFIPKSDAEKYEKYFRTNKTRYPVKHLFYLFGFGWSRNAPEAVYVIPSTALYEYDEETFEITFPNGESMKEKQLRMEDYKVQSGVLIYAFPENGKRLSSQTGAFD
>NC_015571|2083822:2135169|2120934_2121165_-|WP_077070601.1|DBSCAN-SWA
MSLNLSGNYRRKVCPRCGRGFLCGHDLPDMRCDCRTVQLQSHHFEFLRRHYHDCLCLPCLREIANASAEEILQMHR
>NC_015571|2083822:2135169|2083822_2084908_+|WP_013816551.1|transposase|DBSCAN-SWA
MAYQSKNTDEHVTFADALLSKRYRKAQNDFLNQVDRLIDWRPIRTLINKKYTKRQNAIGAPAYDVILLFKMLLLETWYNLSDCALEERINDSITFSRFLGLKMEEVSPDHSTISRFRSALTELGLMDKLLAQFNKQLSRHHISVREGVLVDASLVETPHKPNGTITIEVADDREDNRSEAEKEAEEDYQKQVVRQRKGTDEEARWVYKQKRYHYGYKKHCLTNVQGIVQKVITTAANRSDTKEFIALLQGANIPQGTAVLADKGYACGENRSYLQTHHLQDGIMHKAQRNRALTEEEKQRNKAIGPIRSTIERTFGSIRRWFHGGRCRYRGLAKTHTQNILESIAFNLYRTPGIIMSSSLG
>NC_015571|2083822:2135169|2130563_2131100_+|WP_043890212.1|DBSCAN-SWA
MRRKDREMSREFGLEVIDRAAYGVLSVVDSDGAPYALPLSIVRDGENLYFHSARAGHKVELFTHEPSATIVFVGRVEVPDVYTPEVLESLKEGDSRLSGSMLSRIFTTDFESAIVKGQVIRVADHEECVHALRLICEKYTPEKMDLFDKAVESGMPHTAIYRIKIDMITAKRKLVLPD
>NC_015571|2083822:2135169|2097406_2097979_-|WP_013816566.1|DBSCAN-SWA
MTMSDFSFFTTLQAGWLNAWIPSFGMVLIQFIYMAIFREGGKRAVDTSWYTAKDKANASVSTILQIAILVLSVFVPFKFGTAWFLAGMAVYVLSLVLFVRAFHNYVATPAGKTIKGGVYRWSRNPMYFFFFTGMFGVCIASASLWILLVMIPFIIATHFLILGEERYCEETYGEEYREYKAKTPRYFLFF
>NC_015571|2083822:2135169|2088250_2088838_+|WP_013816555.1|DBSCAN-SWA
MLEKNLIRANEDIVTVTTIAKSMGWGAVSEQSFHRILYLAQILYSFKHEGENIFSYYHFTVTTFGPYSDLIQRSLVFLKSPSILREEEGGLILNSKKEFPLNKDKVEWLKTVMYMLGKYGEKRLFGFIVNDPSYENATQTNNIDGIDTSSPDSETLKVLKDFKVAFEQSIEDTSAISDEKYIELYFEYIFSEIIK
>NC_015571|2083822:2135169|2134446_2135169_+|WP_013816596.1|protease|DBSCAN-SWA
MNSFRERNYQFAPPVTQNLIIINAIFLFATYVLEARFNIDLNDTMGLHYFQADSFNPIQFVSYMFLHDGLSHLFFNMFSLWMFGRLIEQFWGAKRFLIFYVICGLTAALAQQIVWAVDLMPIVNSPAEFVRFPEGTEMLKSAFLNLPTTVGASGAVFGLLLAFGMLFPNGEIYLFFIPIPIKAKWFVIIYGLVELFLVLGVAPMAGGSNIAHFAHLGGMIGGIILILLWRRKGEIDGPYN
>NC_015571|2083822:2135169|2117288_2119097_-|WP_013816583.1|DBSCAN-SWA
METKYIVSALKYRPDSFASMVGQEALSATLKSSIVQQKTAHAYLFCGPRGVGKTSCARIFARAINCLERLPDGEACGRCESCKAFDEQRSMNIYELDAASNNSVDDIRLLIEQANVPPQIGKYKIYIIDEVHMLSQQAFNAFLKTLEEPPSYVIFILATTEKHKILPTILSRCQIFDFKRIPPARIEQHLRYVADSEGIKAEAEALAIIATKADGGMRDALSLFDRIARFSEGNITYANTIENLNILDYDYYFRLTDFFLQGDYRSVLIVLDELLAKGFDGQVIVSGLASFFRDLMMAQDASTLPLLEQSEVVIQRYVDMAARCPTSFLYQSLKILNACDQQYRQSNGKRLLLELSLMNIAALFSKGLTAPPPTHGAQHANPAVSGSVSPRPAPAKEQPSVAPSQSSVPPQPSIGEQRRQPETTAPTITEDKPEQTKVVPPTRPMATSTVGSEGRFTLRGIRNKQEQLQNNIQEVRTEMTESFDEEQLQLAWIEFAETKLSEEIHLKETMVNCLPKLRPGTSAFEVEVLNSRQEEEINNVSARLLGFLADKLCNTTIRMNVRVSESTSLNRVPVSLDEKIERLNQENPLFDELRMRLGLSLV
>NC_015571|2083822:2135169|2101020_2101479_-|WP_013816573.1|DBSCAN-SWA
MKQEKKTLSYYRLRLEVYLKDYHPQLLSDETFIRERSEAAAKTYEEAFLQDNPIGIAESMAMEVLLRGLHFSPYQFIEQIIDNEFANEVPAELSGKLSLLLLEHKEVKDTFDRYHPGDDFDEKPEYDRLYTELTGTIATVMEEHDLLKDILR
>NC_015571|2083822:2135169|2119219_2120866_-|WP_013816584.1|DBSCAN-SWA
MATPEFKYQKPFPMGDDTTEYYLLTKEYVSVDKFGDHDVLKVEPEALRLLARTAFHDIAFYLRPEHQQQVARILSDPEASENDKFVALTFLRNAEVSAKGQLPFCQDTGTAIILGKKGQQVWTGGHDEEQLSHGVYDTYTQENLRYSQNAPLDMYKEVNTGCNLPAQIDLMAVDGMEYDFLCIAKGGGSANKTYLYQETKALLNPKTLVNFLVDKMSSLGTAACPPYHIAFVIGGTSAETNLKTVKLASAKYYDNLPTSGNEGGRAFRDVELEKEVLEAAYRLGLGAQFGGKYFAHDVRIIRLPRHGASCPVGMGVSCSADRNIKAKINKDGIWIEKMETNPTRLIPESMREGTEGTVVKVDLNRPMPEILKELSQYPVSTRLSLSGTIIVGRDIAHAKLKERIDRGEGLPDYIKNHPIYYAGPAKTPKGMPSGSFGPTTAGRMDSYVDLFQSHGGSMVMIAKGNRSQQVTDACKKYGGFYLGSVGGPAAILAQDSIRKVECLEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFTQIREKCKGCALH
>NC_015571|2083822:2135169|2100303_2100663_-|WP_021661933.1|DBSCAN-SWA
MEQERLNHSMDRRKRNNSSSHYRIKTGSDVSILIVASEYGNRACELTELLLCHVGFKTVPVVSVNKGNGYVRLYSWENYVAETCYDKDAESISLSQDEYDDDALLNAAIEKHFLTLTKQ
>NC_015571|2083822:2135169|2088844_2089963_+|WP_013816556.1|DBSCAN-SWA
MKTRFSQNANFKDLLKRNQNAIVSAALNGLEANDNFKLILSLIKAMCDKYKDNSFKYIVISEEDLKNLTNNADSAIELLFTAPSFIQNRHIIIDSNFNIKEVNNDLYNNNNETRRMFTQMSKDDDVVIFMVSPEGIINYFVNGRDGGDSIFYESSTLHSFISKKPISELKNVLEEYRKRLKIRDTYSKFFVEKSHLRSLRTDLKSVLSEEQFIKANKQLLRNTPEDCFRDDLRLYLKEKLNIFFVPKEGMLENLKRLDIVMLDEDGQGLYFIEVKWVGTSIHPLGKKIGITYDAKPRIVPDAFKQSTAYINELLTENIDIKLGYLAVFDARNEDLPDTGKEMSIDLIPEEHRTAYSRHIKLDDFRVINEHPN
>NC_015571|2083822:2135169|2121161_2122103_-|WP_013816585.1|DBSCAN-SWA
MNRICELLGIEHPIISGGMVWCSGWKLASAVSNCGGLGLIGAGSMHPDNLEHHIRSCKAATDKPFGVNVPLLYPEMDKIMEIIMREHVPVVVTSAGSPKVWTPKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGREETTTLCLIPEVVDAVNIPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSLKAVSPTRLLKNKFYQDVFAAEQRGASVEELRELLGRGRAKQGIFEGDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTEI
>NC_015571|2083822:2135169|2096777_2097392_-|WP_013816565.1|DBSCAN-SWA
MRLFKKFISNCRRPENNFWGKMMLAGMNYGHNKMALWCIDECIRPSDEEDILDIGCGGGQNIANFLTRTKGKVCGADYSAQSVAKSVARNRKAVRDGRAEIMKALVSSLPYESATFDLATAFETIYFWPDIVEDFKEVRRVLKPGGRFAVCNEMASEAGNERWISLLDMKIYTPDEIVENMTKAGFTQTSVFTQGNRICVIGHK
>NC_015571|2083822:2135169|2107857_2108544_+|WP_004585427.1|DBSCAN-SWA
MAKKENQQPDNHVGEVVSRSEQFIEKNMTKIGLVILGVFIIVAGIFAYKRFVSEPKAREAAAKVYLAEDKFIQELDSAALNGNGANEMGLLAVIKKYSGSDASNLAKAYAGICYYNLGEYQKAIDHLKGFSSKENMVAPSITRLIGDCYVQLKKYEEAVGYFEKAAAAASNDAITPGCLIKAGRVYEELKQYDKALAAYKQVKEKYYTSMEANTVEADIIRVKSKGAK
>NC_015571|2083822:2135169|2109261_2111793_+|WP_013816578.1|protease|DBSCAN-SWA
MKKSFLLAIVMLFGIAMQGHSAPVTKERALNLARLALRQISLRMGQTAVSDKISIDYVYRQGDAERGITSQEEGSPAYFYVANRGNNEGYALVAADDRIPTILAYSPIGRFDMDSMPDNLRMWLQIYDQEIGLILSGKAQLNEEILRTEGVPAEVHALMDNGHFANDPMRWNQGYPWNNKEPLLPNGNHAYTGCVATAAAQIMRYHSWPLQGEGSFDYHAGSLVGNWSGTFGEMYDWINMPGNPDLDNLTQSQVDAYATLMRDVSASVSMSFYENGSGTYSVYVVGALRNNFRYKRSLQLHVRALYTSQEWHDMIRGELASGRPVYYAGNNQSIGHAFVCDGYASDGTFHFNWGWGGVSNGFYKLTLLSPTSLGIGGEGIGFTIYQEIITGIEPAKTPAEAGTDALPILALKDIEAEYKSESGLNVEYSIYNTGEEQSNLDLGYRLNKADGEVIEVKTSSNNISWYGYGEHPESFSLAPNQLSQGINTITLLYRRTGTEQWEPVRHAQGGYVNSIKVNTTDPNNVVVTVDNNEGKLSIVPNSFVADLNSYEHSTITVQFNSDSPDEIRTPVAFALSTGATADDAISLGWVMAEVPGGSSNYPVVWSKDVLTLSEGDYTLWYRFSINNQKDEWKKIGSVSVKTPTEYTHPLFEVGHNQTSTYTLDMAHNRVLPDFTLKNLGLPFNGELVVVFRQTQSSSGSLWAAQETVHIKQGETFVYKPVVEGPIPDGSYRATLHAFVNGQPQLYLKGKRNYTVKIVNGTAVEAIESSEEIRVFPNPAHDYVEISAPCIPQETSIILFDLSGKIVMKNSLSAGHGRMDVSRLPNGTYILKMDGYTTKINIVH
>NC_015571|2083822:2135169|2094186_2094654_-|WP_013816562.1|DBSCAN-SWA
MSYIDKTLLTGETVTYKAQVHWWVFVYPMKFLLFGLLLISFSSLYIKIPGYVLIAIAVWGIINSYLGRRYAEYVVTNKRVIFKLGLIRRSVVELQLNKAEAIAFGESFWGRIFNFGTVVVTTGGATNTYHYIADPLSFRRAISEEVDKRFGKGNE
>NC_015571|2083822:2135169|2131564_2134420_+|WP_043890124.1|DBSCAN-SWA
MRVSDLCSRLSWLLPVILVGLLCATLVAAERPMAGAVGLHHRRHAALSDSTAKDTVPLAKPIPDSAFRDSLPADSTGSMRQDSVYDDEFELEDIVEYEATDSIVLLGQNRAYLFGKSYVSYQKSRLEANFMYLNTDSSTVYTRYVLDTAGYPMAFPVFKDGEQSFEAKNFTYNFRTEKGIISGVITQQGEGYLTAGKTKKMPDNIMFMQGGRYTTCDNHDHPHFYINLSKAKVHPEKDIVTGPVNLVIADMPLPIGLPFGYFPFSNKYSSGILMPTYGEDNRYGFYLRNGGYYFAFSDYIDLALRGEIFSKGSWGISAQSKYKKRYKYNGSFEANYLVSKSGDKYVPGDYSKTTSLNIRWTHSQDPKANPLQTLSANVNFATGSYFQNSLNTTYDVNARTATTRSSAVSYSRKFPGTPFSITGSMDISQNMRDTTVSLTLPNLSINMSTRYPFKRKTRVGPERWYEKLSVGYSGQLRNSILTKEKDLLQSNLVRDWKNGMRHSVPISLTVPLLDYINLTLGVNYNEWWYTKGIRKSWNEDKKTFLPSDTTYKFRRLYDYSLSAGLSTTLYGMFKPWKPFSFGGNLIMIRHRFTPTVSFSYMPDFTKRRYGFWEHHEHTDQNGKLHTLLYSPYSEQIFGAPSMGNAGSVNFSFDNNLEAKIKSKSDSTGIKKISLIDQFTWSTSYNMFADSIRWSNISASLALRLSKSFTLRLSGLFDPYLTKYYEGEDGKIIPYKSNDLRIFNGKGLARLISTGTSFSYTLNKESLSGLIALFSGKKERRDEKKNTGATPLEGDDAADILEGGRPQNESGGSLLERNRQGGAVDQDGYFAYSIPWSLSFDYSWNIATDYNRYNVNKMEHYYRVTQNLSFRGNIQPTPNWSFGFNANYNFDLKKITSLTCNVTRDMHCWAISASFIPIGAYKSYNFVISVKSSLLQDLKYQQSNRPITNTWY
>NC_015571|2083822:2135169|2114813_2116346_+|WP_013816582.1|DBSCAN-SWA
MLKTFQMKSEMKSQRRTLTTDWGLRQYLLFLLFAILGQSLSAQDRGAIDIIKKAERQTKSRIGVEIRRCRDDSLFVSNRRDEQFCPASLVKLVTSASILRLRGTEIPFYTGVGMDGKIRKGILDGNLIIKGGGDPSLASNYLPTDSGRFAYALVDAVKQWGIKEITGDIIVDASAFDIEGVNDSWLDEDKGNYFGAGVYGFNINDNRIDVILATGKAGSEAHILRIEPPHPEVRWENRIEVIHRGKDTAGCYGEGLDLKRTLTGVLPTNIVSYRLKTDLPDPALYAAAWAKGLLSAAGTLCQGKCRASYQAVPITQELLIYESLPLDSLVRVMNFRSLNHFAEAFVKQLAPLASKNHRGNTTERGLSVIRNYWTSQTGLQHTDISLSDGSGLSRKNRFSPNALSQILIDMISRGDLVTTSFLNSLPLAGREGTVKNFMKDEAIEAYLKSGSMKGVLGYAGYVRFQGEWYSVVLMGNDFSSSAPVRRAFSDFLLSFFSSAISTKQVLLKEK
>NC_015571|2083822:2135169|2101505_2102039_-|WP_012457820.1|DBSCAN-SWA
MNTITADVSVIRNKILEIRGNRVILDYHLAELYGVQTKVLKQAVRRNLQRFPEDFMFELTENEWTELVTNCDRLPETLKHSSVAPMAFTEQGVAMLSSVLRSPTAIEVNIAIMRTFVAMRRMIAGYEELKKRIEDLEVSCNVQFSELYTALTELLEQKEKAEKPRNPVGFIIPKQEK
>NC_015571|2083822:2135169|2094758_2096111_-|WP_043890121.1|transposase|DBSCAN-SWA
MLGKLPEKGQRDLFRPMLKDFIDMKHELAVLADKIDWSYFEKEFAPLYSDRGAPSVPIRLMVGCLMLKHLYNLGDERIREFWVRDVYFQYFCGGEFFEHEFPFDPSDFVHFRNRVGEEGIGKIFAYSVRLHGKEVPKESKFVLSDTTVQENNITFPTDAKLCKKVIDQCNKIAKKEGIIRRQRYTRESKQLVRNAYNGKHPKRVKKANKAKRRLKTIANALLRELDRKMNEAQKRLYENEFSLLKQAVNQKRNDKDKIYSLHKPFTRCIAKGKAHKQYEFGNKVGLITTGKKGRKIITAVQTFLDNPYDGDTIEPLLRQMEDNDLKLPQELAYDRGGRGRREIKGVKIITPDKPKKSDSEYQKMQKRKKFRTRAGIEPIFGHLKKDFRMEQNYLWGEKGIHINAYMAATAWNLKKMLEKIKENLLRSIFHWFLPMEKIYFYSFLFKKINC
>NC_015571|2083822:2135169|2112918_2114589_+|WP_013816581.1|DBSCAN-SWA
MKKLLQAKALILALGLFQLPAIAQTQMQADRTNGQFATEEMQRAFQETNPPAGPVRAIAEYERSAAVLVRYPFGIPMELIKELAKNDKVITIVASESQKNTVITQYTQSGVNLSNCDFIIAKTDSYWTRDYTGWFAMYDTNKVGLVDFIYNRPRPNDDEFPKYEAQYLGIEMFGMKLKQTGGNYMTDGYGSAVQSHIAYTENSSLSQAQVNQKMKDYLGITHHDVVQDPNGEYINHVDCWGKYLAPNKILIRKVPDNHPQHQALEDMAAYFAAQTCAWGTKYEVYRALATDEQPYTNSLILNNRVFVPVNGPASVDNDALNVYKTAMPGYEIIGVKGASGTPWLGTDALHCRTHEVADKGYLYIKHYPILGEQAGPDYKIEADVVSCANATISPVQCYYRINGSGSFKAADMTMESTGHYTYSFAGLNKNDKVEYYISAADNSGRKETYPFIGEPDPFKFTCMNETNTCTVTGAAKALRAWFNAGRSELAVSVSLNIAGTYRIKLYNTAGEEVAAMTKELVAGTSVFSMDVYSQAPGTYVLVVEGNGIRETMKILK
>NC_015571|2083822:2135169|2106988_2107672_+|WP_004585426.1|DBSCAN-SWA
MISIVLVDDHELYRVGLRAAISQMQGLAEIVGECSSCEELETFLKEQKEPGLIILDIWLPDGNGVNIARKLKKLYPAVKIIILSSEVSEKTVNELLAIDVEGYICKTAQINDIGNAIRTVTTGSHFYGKSVSKMILDICVSRSADQSHKKSKKQQQQQNDSSELTQREKEVVQYLCDGYSAKETAEKMHLSYRTVETHRSNILHKLGFTNAAELIRYAVKSGLVDWQ
>NC_015571|2083822:2135169|2084970_2085402_-|WP_158309342.1|DBSCAN-SWA
METIFVEKSNAQYRYRNVYFALIADKMTQFLVAVKIVSVCTFAFGFTDTCFNRLQFCPACFQKHRRNGVYSLQMILQQLGTDNPVTSKSLDVNPLYLLLEHLQPEIQFSVGCFALLRPLKNKEVEGRGVLRIKGASERGGSKE
>NC_015571|2083822:2135169|2102074_2103307_-|WP_013816574.1|integrase|DBSCAN-SWA
MKSQFRSVFYLRSNYINKEGKTPILIRIYLNKERLSLGSTGLSVNAQLWDSEKEKVKGHSAEALEVNRKIEEIRADILTIYKRLEVTVDDLTPERIKSEYCGQTDTLNSIMELFDKHNEDVRAQVGINKTAATLQKYENSKRHFTRFLKAKYNRTDLKFSELTPLVIHNFEIYLLTVAHCCPNTATKILKLFKTITLYGRRHGFLSHDPFVNKRFHTQDSNRGFLTDEEIQRIIGKEISIPRLDLVRDIFIFSCFSGLAYIDVSNLTEDNIVELDGREWIMTRRQKTRVATNIILLDIPKRIIEKYAPVRKNGHLLPILSNQKMNAYLKEIADLCNIRKPLSFHMARHTFATMSLSKGVPIESVSKMLGHTNIKTTQIYARITNKKIEQDMLKLSDKLDIFRSPVSQAKQ
>NC_015571|2083822:2135169|2127045_2128731_+|WP_021664251.1|DBSCAN-SWA
MNMQWLNDLLFGVGVGHSILLVAVTIALGIWLGKIKIFGISLGVTFVLFVGIVLGHFGMNLHPDVHHFFKEFGLILFVYSVGMQVGPGFFSSLRKGGLTLNLLAMGVVFLGVLTTVILHFVTGISMSTMVGILSGAVTNTPGLGAAEQTFHDLTGTGDPTITLGYAVAYPLGVVGIIASMLIVRAIFKISVAKEKEKMDNLEHNDDNQAIALSLVVKNPAVFSKTLAEVRQLLKGHDYVISRTMDSRTNSISLAHSDTVLNENDRVFVITNPQNAAVISNFIGTEVQMDRKQWIPTESHLVSRRFIVTKSELNGKTLGSLQLRKLHGMNVTRVNRAGVEMVALASLPLQVGDRLTVVGSELVMPKVEELIGNSVKRLNEPNLMSIFIGIGLGILLGSLPIVLPGIPQPVKLGLAGGPLVVAILLSRFGYRYKLVTYTTPSANLMLREIGITIFLACVGLGAGEGFVDTIVNKGGFTWIGYGFIITLLPLLIIGFIARKGYKINYLTLMGMLAGSTTDPPALAYANNTTNHDAPAVGYATVYPLTMFLRVLTAQLLILFFCS
>NC_015571|2083822:2135169|2099775_2100297_-|WP_013816570.1|DBSCAN-SWA
MATHNFAYENRLIHVEDEDYESGNVPEHKEYVQGCNRNYPSYYLDEYRASFYTLDIVITSAYYSGGCIDYIQDDSYLNNITFCDGYDEDATDTIMRDFKAYHPDYEKVRELARKIGEDWKNYTAYDALQAYLFALEKPEADKIIDKIKTDYGYRELTKTGSFCNGEALYEQIA
>NC_015571|2083822:2135169|2099231_2099513_-|WP_013816569.1|DBSCAN-SWA
MNTFDFYQDSKVICRMRTKFQVKAENYEQAVAIIKSWQGEDVMNHDDEEQVIFVEGETLLDTSENLSPEENGGRPTIEVFDDKGKEITNNLNP
>NC_015571|2083822:2135169|2096224_2096737_-|WP_013816564.1|DBSCAN-SWA
MNLIKEFSTALCSEKRSGRIPEELDFFGSLVGEWEIEWTDRLYDATPRRVKGEWIFSWVLDGTAIQDLFIVPSRAERLINKQPDAEYGTTLRIFNPKTSAWDIFYGCTGEAIRLARKTGDDIVLTENTTGKMRYVFSDMTATAFHWRKEQQNENGTWQTVARVVATKRRE
>NC_015571|2083822:2135169|2097975_2098620_-|WP_013816567.1|DBSCAN-SWA
MDKKLRLTGYVGVAGSLLMYTGDMLLYFTTQPIPDREKDLLLSMGAVPLERLIAGGIIGPLAAVLYIIGFYHLFLRVKKARRKTACWMLASLSVSIIVGGAYHAFFPAFGIVSSQGHPEIIDHFLSYIGWLGGFSFFLMGIGWLLFSVLVLQKQTSFPRWIVFATPLITIWLNFLWKTLPQPFLLLIAGGWNNLVYTLIFAVSLITLKKQYHPR
>NC_015571|2083822:2135169|2086244_2088257_+|WP_043890209.1|DBSCAN-SWA
MSRQIYLPELLSINIKNYTLYPNGLDYTFDFVKGVNLVLGGNGMGKTTFVNIIRFAILGLYKKPFGYTRTYQGSIIEKRQLFPQKYFSNRMDDSVHTDTSPTVSISMKINNVTVELTRDLSSITLTQLKVNGTEVSGTLVNQFSYEKLSDVAKADTLPYKYEEIIKVNTNLEFDDLIFFVNEVLFFGEDHKTILWNDGDFFPDVQSELFNKYFNDPDLDKKRQEAIRKAKYFDSLSRHSSEDMRAINKVLSKMKDAPVTGNSITNKGNTALILIDLKGRLVEMDAKLAAIQKERASKSQDISLLQNDINKISLSTNDIDKELKQIEDKLNSHIWETLHPSYHVFIKNIQLNRICPMCNQPNDDLVAKVTNEQNNCFACSTPINTNTEADTILRKHFDEISTHRKTLYQSINSKKQTIQNIEQQIIKLDSEFSKIELERRAIQQKVRELEYENAMSDNSQNSIQPFLDEVNRLTQQKEAYQKQRDEQYDIVTSISNEIEDVITANVHVFSSIFAQYAGKFLGVSCELTYIKQAGDTNKRFYPVIDGKVRFYEEEMSESQRFFVDHSFRMSILTFFYRTPSFYIVETPDSSLDISYERNAASVFTEFLKKPNSLIITSNLNNSLFIEHLLNQKDIELGIVGLLEIAKQSTIQNTNEQLKSIYQHIKTRLESC
>NC_015571|2083822:2135169|2116681_2116852_+|WP_010956309.1|DBSCAN-SWA
MAYVINDSCVACGSCIDECPVSAISEGSIYKIDADTCIDCGTCAAACPSEAIHPAE
>NC_015571|2083822:2135169|2108635_2109121_+|WP_013816577.1|DBSCAN-SWA
MATAYHNLSDYDYESVPCGKDLRIGIAVAEWNRNITEPLMKGAIDTLLEHGVSADNIIVQHVPGTFELTYASAYLAEQHEVDAVIAIGCVVRGDTPHFDYICQGVTQGITQLNIDGFVPVIFGVLTTETMLQAEERAGGKHGNKGTEAAVTALKMAGLERI
>NC_015571|2083822:2135169|2128820_2129339_+|WP_013816591.1|DBSCAN-SWA
MMTDTQDNELIVFGEHNVHAENLSIGHLVTYFPWTKLFNALGMVGAYPALLYTNEKADALYEVVSSLLGEWIVSGDPWIDLSLVFHDVEGGQPEGDLEVVLSSHLNEEDIMPVPSLFLYDMGCYLLEAAAAWIADQEAYGMQTVIERKDISRRPSEKGLRLVGHWILKAIEC
>NC_015571|2083822:2135169|2104584_2104779_-|WP_013816575.1|DBSCAN-SWA
MSENKTYTEAMRRLEEIVRVIEHESPDVDELTKLAEEAIALIGFCREKLTVADKQIEELMAKLS
>NC_015571|2083822:2135169|2099535_2099763_-|WP_005874553.1|DBSCAN-SWA
MKTILIRLTVVAAFIIGTVCICSMLITEEAITVLTLLTALYFVRFLVRTALYVFFTLVRWLCIIALLGLLFCSLF
>NC_015571|2083822:2135169|2122535_2125139_-|WP_013816586.1|DBSCAN-SWA
MRKRILQLFLTTLLLALGSSLAIAQTVVTGKVIDSETSEPLIGVSVSTGQGASLRGVTTDMDGGFRFEVPAKSVLTFRCVGYATVTRSIGRGSQEDLGTILLDPQAIGLDEIQVIASVVPKDRMTPVPVSNIRVADIQAASLNVEFPELVKSTPSTYTTKGSGGFGDGRTNVRGFDTYNFGVLINGVPVNGMEDGKVYWSNWSGLMNQASTIQIQRGLGASKLGISSVGGTMNIITKTTDANTGGSAYVGMGNDGLHKESFSISTGMNDGWAITIAGSHMTGLGYVKGLKGRAFSYFFNVSKKFNERHTLSLTGFGAPQWHNQRSSKYSVADYDKYGIRHNQSFGYLRGELTPTAYAYNTYHKPQFSLNHFWKMDENTSLYTAAYASLATGGGRRAYGKNSKWVLINYNTGQPYEQTKVTPDGLIDYDAVLAANAAASNGSEAIFALGSNSHKWFGLLSSFKKKLNSSLTLTAGYDGRYYRGDHYDKITDLLGGSYYIEDPKTKLAYHTEGQQLKVGDIVNRDYTGEIMWQGLFAQMEHSSEWIDAFVSGSINYELYRNHNYGGSKSTGYLPGVSPWKSFLPWSGKAGLSYKFAQGHNVFANGGFFTRAPLFGNVYAAGAIIPNDKANMEKVLTGEVGYGFTNHKNFEFNINGYYTKWMDRVTSKRIGNEYVYLNGVDAVHCGVEAEISYRPIRQIDLRGMFSLGDWTWQNNVSYTSYDEAGNETGQDITYIKGLHVGDAAQMTAAVSADIELFKGFHVIGKYNFLGKNYAGFNPATRNAQQYEADGKEIVESWKLPDVGLFDLSASYNFKLGSLSTTFYFNMDNVADKRYVSDADDNIIGKKHDEASALVWYGFGRTWSTGIRVNF
>NC_015571|2083822:2135169|2103919_2104588_-|WP_004585423.1|DBSCAN-SWA
MKQKRYALIVAGGHGLRMGADRPKQFLLLAGLPVLMHTLNRFAPHVDAIVLVLPTDHHAYWQELCRKYDFSVSHRVVAGGNTRFASVRNGLQVVPDGVLVAVHDGVRPLVSAETIDACFDLAELKGAVAPCRPMTESLRYYATDGNYAVDRSRYVTVQTPQTFRSEWLREAYRQPYEEYFTDDCSVYEHHFGRPVALIVGNIENIKLTTPLDLSLAKLLLTS
>NC_015571|2083822:2135169|2091769_2092849_+|WP_013816559.1|transposase|DBSCAN-SWA
MAYQSKNTDEHVTFADALLSKRYRKAQNDFLNQVDALIDWRPIRTLINKKYTKRQNAIGAPAYDVILLFKMLLPKTWYNDCALEERINDSITFPRFLGLKMEEVSPDHSTISRFRSALTELGLMDKLLAQFNKQLSRHHISVREGVLVDASLVETPHKPNGTITIEVADDRQDNRSEAEKEAEEDYQKQVVRQRKGTDEEARWVYKQKRYHYGYKKHCLTNVQGIVQKVITTAANRSDTKEFIALLQGANIPQGTAVLADKGYACGENRSYLQTHHLQDGIMHKAQRNRALTEEEKQGNKAIGPIRSTIERTFGSIRRWFHGGRCRYRGLAKTHTQNILESIAFNLYRTPGIIMSSSVG
>NC_015571|2083822:2135169|2129335_2130301_-|WP_005873381.1|DBSCAN-SWA
METKQSHAHACCSEHKHEHEAHHHGHHHHHHHHGESGSNLLFAFAMNLFFAIVELVGGIFTGSVAILSDALHDFGDSISLGIAWRLQKLSEKGRDRSFSYGYKRFSLLGALLISIILLVGSVFVIIAAVQRFSMPGEPKAGGMLILAIFGLVVNGLAALRLKGSSSLNERAVMLHLLEDVLGWAAVLVVSIVMLFVNAPILDPILSLCITAWILYNVYGNLRETFKVLLQGVPDGIDLEGLKTDILSLPHIRSVHDIHLWTLDGESHVMTIHVVYCPDDFSSPQAVFDMKESVREKCSAHGIRHATIELDPEGCSCGMESC
>NC_015571|2083822:2135169|2105167_2106976_+|WP_013816576.1|DBSCAN-SWA
MLSAKEINVDSLFQIAADRTLSATEKKKRYEEMGKQLELHQQVGSAADAYSLAIKFCRDGGSTEELPYLLLKYATMATHAGRYSNAITALEEIMRLLKDKNDNIILARTYMQIGIVFFFQEKWDDALVFYERALQIAQKKKEERGISIAYNNMANIYQKKGNTQEAYSYYNKALDIQRANGDSVSMCNSLMNIGTIMINEKNPEDSYKILKEALTIASKINDIEIQALSYAHLAYYYAWRSEYGKANEVLTIAENLACHAGYNQTRLAILDIASSIYAEYGLYSLAYECQKRSKLLADSIAAKQMQEKITEFDIRFKSKEKEAEIALKNQELHLARKLHIALIIISTLMVATIITLIIHAAKRYRQNKRLREMNDTRNRLLSIISHDIKGPAIAQKMALDTILSSSSDCGSMTRNMLSSIRNSVATELALLQNLLDWSNIQIGNLAPKFVVFNIVENIGKVINLYSISARNKDISLHLEAPKQCLVHADQQMINTVIRNLLSNAIKFSKAGSVIHIRVEEKEKAMGIKVSVSDKGIGMSKKQITDILESDKNKKATAGTDGEIGSGLGLIICKGLLKKNKSKLCIDSKEGKGSVFSFVLASA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013816551.1|2083822_2084908_+|transposase	IS5 family transposase	A0A077K814	Ralstonia_phage	9.9e-20	28.1
WP_158309342.1|2084970_2085402_-	hypothetical protein	NA	NA	NA	NA
WP_043890209.1|2086244_2088257_+	AAA family ATPase	NA	NA	NA	NA
WP_013816555.1|2088250_2088838_+	hypothetical protein	NA	NA	NA	NA
WP_013816556.1|2088844_2089963_+	hypothetical protein	NA	NA	NA	NA
WP_013816557.1|2089975_2091268_+	methyltransferase	NA	NA	NA	NA
WP_013816559.1|2091769_2092849_+|transposase	IS5 family transposase	A0A077K814	Ralstonia_phage	1.0e-16	26.5
WP_013816560.1|2093009_2093474_+	DUF3872 domain-containing protein	NA	NA	NA	NA
WP_013816561.1|2093504_2094152_-	hypothetical protein	NA	NA	NA	NA
WP_013816562.1|2094186_2094654_-	PH domain-containing protein	A0A2H5BNL9	Klebsiella_phage	5.8e-09	31.1
WP_043890121.1|2094758_2096111_-|transposase	IS5 family transposase	NA	NA	NA	NA
WP_013816564.1|2096224_2096737_-	hypothetical protein	NA	NA	NA	NA
WP_013816565.1|2096777_2097392_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_013816566.1|2097406_2097979_-	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_013816567.1|2097975_2098620_-	hypothetical protein	NA	NA	NA	NA
WP_013816569.1|2099231_2099513_-	hypothetical protein	NA	NA	NA	NA
WP_005874553.1|2099535_2099763_-	hypothetical protein	NA	NA	NA	NA
WP_013816570.1|2099775_2100297_-	hypothetical protein	NA	NA	NA	NA
2099808:2099823	attL	NA	NA	NA	NA
WP_021661933.1|2100303_2100663_-	hypothetical protein	NA	NA	NA	NA
WP_013816573.1|2101020_2101479_-	DUF1896 domain-containing protein	NA	NA	NA	NA
WP_012457820.1|2101505_2102039_-	ORF6N domain-containing protein	NA	NA	NA	NA
WP_013816574.1|2102074_2103307_-|integrase	site-specific integrase	H7BUI8	unidentified_phage	4.4e-32	38.1
WP_004585423.1|2103919_2104588_-	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_013816575.1|2104584_2104779_-	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_013816576.1|2105167_2106976_+	tetratricopeptide repeat-containing sensor histidine kinase	NA	NA	NA	NA
WP_004585426.1|2106988_2107672_+	response regulator transcription factor	NA	NA	NA	NA
WP_004585427.1|2107857_2108544_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_013816577.1|2108635_2109121_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	9.9e-28	42.9
WP_013816578.1|2109261_2111793_+|protease	thiol protease/hemagglutinin PrtT	NA	NA	NA	NA
WP_013816581.1|2112918_2114589_+	peptidylarginine deiminase PPAD	NA	NA	NA	NA
WP_013816582.1|2114813_2116346_+	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	NA	NA	NA	NA
WP_010956309.1|2116681_2116852_+	4Fe-4S binding protein	NA	NA	NA	NA
WP_013816583.1|2117288_2119097_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	6.1e-46	39.1
WP_013816584.1|2119219_2120866_-	fumarate hydratase	NA	NA	NA	NA
WP_077070601.1|2120934_2121165_-	cysteine-rich CWC family protein	NA	NA	NA	NA
WP_013816585.1|2121161_2122103_-	nitronate monooxygenase	NA	NA	NA	NA
WP_013816586.1|2122535_2125139_-	TonB-dependent receptor	NA	NA	NA	NA
WP_021664251.1|2127045_2128731_+	putative transporter	NA	NA	NA	NA
WP_013816591.1|2128820_2129339_+	hypothetical protein	NA	NA	NA	NA
WP_005873381.1|2129335_2130301_-	cation transporter	NA	NA	NA	NA
WP_043890212.1|2130563_2131100_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_043890124.1|2131564_2134420_+	LPS-assembly protein LptD	NA	NA	NA	NA
WP_013816596.1|2134446_2135169_+|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
2142958:2142973	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage
NC_015571.1|WP_004584358.1|1072052_1072466_-|PcfK-like-family-protein	1072052_1072466_-	137 aa aa	40	NA	NA	No	NA

Protein sequences of NC_015571.1|WP_004584358.1|1072052_1072466_-|PcfK-like-family-protein

>NC_015571.1|WP_004584358.1|1072052_1072466_-|PcfK-like-family-protein
MKGTEHFKDVIQNYLETRASYDELFAGNFRKENKNIDECITYILTEVQRMGCAGLSDEEVYSLAVHYYDEDNIKVGTSINCQVVVNHTIELTEEEKAEARKKAIERYQAEEYRKLTAKKPKAEKQAEEQLQPSLFEF

gnl|BL_ORD_ID|40 information

• hit_Aca_id: gnl|BL_ORD_ID|40
• identity: 0.5815602836879432
• query_coverage: 1
• hit_coverage: 1.0