CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_015737	Clostridium sp. SY8519, complete genome	8 crisprs	DEDDh,WYL,cas3,csa3,PrimPol,cas8e,cse2gr11,cas7,cas5,cas6e,cas1,DinG	1	18	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_015737_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015737_1

595048-595122

Orphan

Consensus_repeat	Method
GGCTGTACGCTCCGGTTCCGGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015737_1

>merge|NC_015737|1|595048-595122|CRISPRCasFinder
GGCTGTACGCTCCGGTTCCGGCCGTTGATTGCCCGGCTGATCCGATCTTCCGGCTGTACACTCCGGTTCCGGCCG

>NC_015737|1|1|595048-595122|CRISPRCasFinder
GGCTGTACGCTCCGGTTCCGGCCG	TTGATTGCCCGGCTGATCCGATCTTCC
GGCTGTACACTCCGGTTCCGGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_015737.1\|WP_013976516.1\|600898_601630_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213186
NC_015737.1\|WP_041728267.1\|600183_600897_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213191
NC_015737.1\|WP_013976512.1\|597508_598060_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013976508.1\|592623_594081_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NC_015737.1\|WP_013976504.1\|587409_587910_-\|ATP--corrinoid-adenosyltransferase	unknown	unknown	gnl\|CDD\|376827
NC_015737.1\|WP_013976520.1\|604740_605304_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NC_015737.1\|WP_013976513.1\|598241_599240_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119323
NC_015737.1\|WP_013976500.1\|582255_583242_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NC_015737.1\|WP_013976502.1\|585344_586109_-\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|234595
NC_015737.1\|WP_013976501.1\|583344_585309_-\|fructose-bisphosphatase-class-III	unknown	unknown	gnl\|CDD\|377726
NC_015737.1\|WP_013976505.1\|588160_589999_+\|translational-GTPase-TypA	unknown	unknown	gnl\|CDD\|224138
NC_015737.1\|WP_013976514.1\|599252_600119_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
NC_015737.1\|WP_013976503.1\|586194_587079_-\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NC_015737.1\|WP_013976511.1\|596120_597395_+\|ArsB/NhaD-family-transporter	unknown	unknown	gnl\|CDD\|238536
NC_015737.1\|WP_041728261.1\|591495_592287_-\|phosphoribosylformimino-5-aminoimidazole-carboxamide-ribotide-isomerase	unknown	unknown	gnl\|CDD\|215245
NC_015737.1\|WP_013976509.1\|594236_594872_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374106
NC_015737.1\|WP_013976518.1\|603323_604043_-\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013976519.1\|604046_604694_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_015737.1\|WP_013976506.1\|590147_591365_-\|LL-diaminopimelate-aminotransferase	unknown	unknown	gnl\|CDD\|181053
NC_015737.1\|WP_013976517.1\|601800_603069_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380560

Protein	Function_ID	Function_description	E-value
NC_015737.1\|WP_013976516.1\|600898_601630_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	1.08263e-81
NC_015737.1\|WP_041728267.1\|600183_600897_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213191	cd03224, ABC_TM1139_LivF_branched, ATP-binding cassette domain of branched-chain amino acid transporter. LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.	1.45484e-111
NC_015737.1\|WP_013976514.1\|599252_600119_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	3.54118e-58
NC_015737.1\|WP_013976508.1\|592623_594081_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NC_015737.1\|WP_013976504.1\|587409_587910_-\|ATP--corrinoid-adenosyltransferase	gnl\|CDD\|376827	pfam02572, CobA_CobO_BtuR, ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin adenosyltransferase, EC:2.5.1.17, involved in cobalamin (vitamin B12) biosynthesis. These enzymes catalyze the adenosylation reaction: ATP + cob(I)alamin + H2O <=> phosphate + diphosphate + adenosylcobalamin.	4.38813e-22
NC_015737.1\|WP_013976520.1\|604740_605304_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	2.33051e-24
NC_015737.1\|WP_013976513.1\|598241_599240_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	3.09267e-54
NC_015737.1\|WP_013976500.1\|582255_583242_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	1.67923e-86
NC_015737.1\|WP_013976502.1\|585344_586109_-\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	1.68431e-99
NC_015737.1\|WP_013976501.1\|583344_585309_-\|fructose-bisphosphatase-class-III	gnl\|CDD\|377726	pfam06874, FBPase_2, Firmicute fructose-1,6-bisphosphatase. This family consists of several bacterial fructose-1,6-bisphosphatase proteins (EC:3.1.3.11) which seem to be specific to phylum Firmicutes. Fructose-1,6-bisphosphatase (FBPase) is a well known enzyme involved in gluconeogenesis. This family does not seem to be structurally related to pfam00316.	0
NC_015737.1\|WP_013976505.1\|588160_589999_+\|translational-GTPase-TypA	gnl\|CDD\|224138	COG1217, TypA, Predicted membrane GTPase involved in stress response [Signal transduction mechanisms].	0
NC_015737.1\|WP_013976503.1\|586194_587079_-\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	5.40079e-153
NC_015737.1\|WP_013976511.1\|596120_597395_+\|ArsB/NhaD-family-transporter	gnl\|CDD\|238536	cd01116, P_permease, Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.	1.04261e-123
NC_015737.1\|WP_041728261.1\|591495_592287_-\|phosphoribosylformimino-5-aminoimidazole-carboxamide-ribotide-isomerase	gnl\|CDD\|215245	PLN02446, PLN02446, (5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.	4.32088e-128
NC_015737.1\|WP_013976509.1\|594236_594872_-\|hypothetical-protein	gnl\|CDD\|374106	pfam15782, GREB1, Gene regulated by oestrogen in breast cancer. GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.	0.00590672
NC_015737.1\|WP_013976519.1\|604046_604694_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	2.65367e-43
NC_015737.1\|WP_013976506.1\|590147_591365_-\|LL-diaminopimelate-aminotransferase	gnl\|CDD\|181053	PRK07590, PRK07590, L,L-diaminopimelate aminotransferase; Validated.	0
NC_015737.1\|WP_013976517.1\|601800_603069_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380560	cd06337, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.	1.41459e-110

>NC_015737.1|WP_013976509.1|594236_594872_-|hypothetical-protein
MKLKKAFALIGCTALVGILAAGCGTASSSSGSSGGTSASSSGETSSEKTSDSDTVYGKVTKVDGSTITIQVAKLNKPKDAPNGAKEGSLDSSNSSGSGSSSDSSSSDTGKSGKNTDGKAPGTMDPSDMVTLSDETMKVTVGDSVDISDIARGDYVTITMDGDDVKSVKEGIQMEKPSGKAPTAPDSGNSSGSGSSSGSGSSSGSSSDSSGS
>NC_015737.1|WP_013976508.1|592623_594081_+|IMP-dehydrogenase
MAKIIGEGITFDDVLLVPAYSEVTPNMVDISTYLTKKIKLNIPMMSASMDTVTEHRMAIAMARQGGIGIIHKNMSITAQAEEVDKVKRSENGVITDPFSLSADHTLQDADDLMAKFRISGVPITDNEGKLVGIITNRDLKFETDFSKKISESMTSEGLITAQEGITLDEAKKILAKARKEKLPIVDVNFHLKGLITIKDIEKQIKYPLSAKDDQGRLLCGAGVGITHDMMDRVDALVGANVDAIVVDSAHGHSKNILDAVSRIKNKYPDLQIIAGNVATGEATEALIQAGADCVKVGIGPGSICTTRVVAGIGVPQISAIMDCYAVAKKYDIPIIADGGIKYSGDLTKALAAGASVCMMGSLFAGCDEAPGEFELYQGRKYKVYRGMGSLAAMENGSKDRYFQEDARKLVPEGVEGRVAAKGSVEDTIFQMIGGIRSGMGYCGAKDIPTLTKTSHFVKISAAALRESHPHDIHITKEAPNYSIEE
>NC_015737.1|WP_041728261.1|591495_592287_-|phosphoribosylformimino-5-aminoimidazole-carboxamide-ribotide-isomerase
MEFRPCIDIHNGKVKQIVGGSLRDEGDRAAENFVAEQDSVFFADFYKKDGIRGGHVILLNGKDSEYYEATKQQALAALRAYPGGLQAGGGINPENAREFLEAGASHVIVTSYVFHDGTVNYENLEKLLAVTGREHLVLDLSCRKRDGAYYIVTDRWQKFTREKVTAELLDRLAEYADEFLIHAVDVEGRASGIEEDLAAMLGAWNRIPVTYAGGVGSFRDLARLKELGQNHVNVTIGSALDLFGGNMRYDEVLRAVREPVVRP
>NC_015737.1|WP_013976506.1|590147_591365_-|LL-diaminopimelate-aminotransferase
MFKVNENYLKLPGSYLFSTIAKKVAEYQEAHPEKELIRLGIGDVTQPLVPAIIQALHGAVDEMGKAETFRGYAPDLGYDFLRSAIVANDYKARGCEVYEDEVFVSDGAKSDSGNIQELFSEDSRIAVCDPVYPVYVDSNVMAGRTGVYNAETETWSNVIYMPTTRENGFVPEFPKETPDLIYLCLPNNPTGTTLTKDQLQDWVDYANRVGAVIIFDAAYEAYITEENVPHSIYECEGARTCAIEIRSFSKNAGFTGVRLGFTVVPKDLKCGDASLNAMWARRHGTKFNGAPYIVQRAGEAVYTPEGKAQIREQVGYYMKNAATIRKGLADAGFEVYGGINAPYIWMKTPDQMTSWEFFDYLLNEVNIVGTPGSGFGPSGEGYFRLTAFGTYENTLAALERFKAMK
>NC_015737.1|WP_013976505.1|588160_589999_+|translational-GTPase-TypA
MIQKREDVRNIAIIAHVDHGKTTLVDELLKQSGVFRENQEVQERVMDSNDIERERGITILSKNTAVFYKGTKINIIDTPGHADFGGEVERVLKMVNGVVLVVDAFEGAMPQTKFVLMKALALDLPVIVCINKIDRPEARPTEVVDEVLELLMDLDASDEQLDCPFLFASAKNGYAMRSPEDEPKDMVPLFETIIDHIPAPEGDPDASTQVLISTIDYNEYVGRIGVGKVDNGCLRINQDAVLVNHHDPDKQKKVRISKLYEFDGLNKVEVKEARIGSIVAISGIADIHIGDTICDPENPTAIPFQKISEPTISMNFIVNDSPLAGQEGKYITSRHIRDRLFRELNTDVSLRVEETDSPDSFKVSGRGELHLSVLIENMRREGFEFAVSKAEVLYHTDENGKKTEPMELAYVDVPDEFTGAVIEKLSQRKGELLNMGSISGGYTRLEFRIPSRGLIGYRGEFMTDTKGNGIINTIFDGYAPYRGDISYRKQGSLIAFEPGESVTYGLFSAQDRGTLFIGPGEKVYSGMVIGQCSRQEDIELNVCKKKHLTNTRTSSSDEALTLTPPKILSLEQALDFIDTDELLEVTPQSLRIRKKILDPTLRKRASFSKKNS
>NC_015737.1|WP_013976504.1|587409_587910_-|ATP--corrinoid-adenosyltransferase
MSNIRAYFGNGRGKTAAALGYAVTQAARGASVIIIGFLKQRDDEVFDYLTRLEPEIRCFRFQKSKELFEELPPECRNDEVMNMKNGLNYAKKVLQIGECDILILDEVLGLVDHGIITADELLELAGSGEEHMQVIVTGQKLDEALKSRIPCVYELKTCRQDGQDVE
>NC_015737.1|WP_013976503.1|586194_587079_-|4-hydroxy-tetrahydrodipicolinate-synthase
MPIFTGAAVAIVTPMKDNYEVDYDGLQENIDYQVEHGCDCIVIAGTTGEGSTLSEEEHMKVVKAAVDFTRHRIPVVAGTGSNCTRTAIELSRQAEADGVDGLLIVTPYYNKATQNGLIRHYSAIAEEVKTPIILYNVPSRTGCNIQPETVAELVKRNDAIVGIKDATGNLSQAAQMMNLCDGNLELYSGNDDQVVPLLSLGGLGVISVLCNIAPQYTHDMVTEFLQGNVKKSAKMQLDAIPLINALFCEVNPIPVKSAMDLMGMKAGPLRAPLYELSAEHREQLKTEMTRFGLL
>NC_015737.1|WP_013976502.1|585344_586109_-|4-hydroxy-tetrahydrodipicolinate-reductase
MTRIIMNGCNGHMGQVIAGLCQEDSDTEIVAGIDISGEAQNGFPVFRTIAECDAEADAIIDFSHVSCIDSLLAYSAEKQIPVVVCTTGLSKEQEDLVTETAKKVAVLKSANMSLGVNTLMALLKTAARTLAPAGFDMEIVEKHHHRKLDAPSGTALALAASMNEALDNAYEYKLDRSRERKARDPHEIGIQAVRGGNIVGEHEVIFAGMDEVITFKHTAYSRAIFGKGAIEAAKFLKGKPAGYYDMSDVIAARS
>NC_015737.1|WP_013976501.1|583344_585309_-|fructose-bisphosphatase-class-III
MNKHELKYLKVLSNQYPSISSAATEIINLKAILSLPKGTEHFISDLHGEYEQFIHIMNNGSGAVRRKIEDEFGVSLSVVEKRQLSMLIYYPELKIRQIEKQITDKEELEDWYRVTILRLCRVCRQAASKYTRSKVRKAMPKDFAYIMDELMNGRTDIADQEAYYQQIVNSVIETRRADEMIIDFCKLIRRFVIDHLHVLGDIFDRGQYPHLIMDELMKHHSLDIQWGNHDIIWMGAAAGSEACMCNMLRISAKYGNLSILEDNYGINLLPLAQLALKVYANDPCKAFHLTVDDEDYDQTNRSLDEKMHKAIAIIQFKVEGQLIRKHPEFHMDDRLLMEKIDLKKGTVLCYGVEYPLTDTNFPTMDPKDPYKLSPEEEEVVRRLRASFEGSVRLQEHIRFLYKKGSLYKVYNGNLLFHGCVPLKEDGTFNEVEIYGKKYKGKALYDILDFYARRGYFSTDPEEKKRGQDILWFIWKNKESPVFGKDKMTTFERYFIADKRTHEEPKNPYYHLYEKKEVVNRILHEFGLTSEDSHIINGHMPVKAKKGESPAKCGGKVLVIDGGFSKAYQKTTGLAGYTLTYNSYGLILTAHQPFLSLEDTVLKEQDVESEIILKQGVIQRKRVGDTDTGKVLQENIEELEQLLQAYRSGEILEKE
>NC_015737.1|WP_013976500.1|582255_583242_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MTNHNIWVIFELTNHTPKRVSLELMQKASDLAREAGQKAVAVIVDSAPADAAAAAFANGADEVITNASDSCFEDICYITEKLAAENAPLAILIGSTNFGHDLSAALSARCGMGLAADCTDVILSIQESGSVINWIRPSYDGKLNTNISISAFPQIGTFRPGTLKASEDFPAKAPGAVTDAAIEVPASVRLTRFLGFIPDDELMKTNIEDADILISGGRGMGSKEAFDQLFELARLVDGNVAASRAAVDEGWTDRDRQVGITGKTVTPKLYLAFGISGAEPHVAGMKESDVIVAVNTDPQAPIFDLAHYGVVADLHKVIPVMIDKLKNR
>NC_015737.1|WP_013976511.1|596120_597395_+|ArsB/NhaD-family-transporter
MTQEIIALVIFIVVITLIISGKVHETTAALAGAAALLITHIFTITKAISYVDFDTICVLVGMMMFVSVVKHSGLFEYVAIKCAKMAKGDPWKIMVAFMILTAVCSAFLDNVTTVLLVGPMAIIIAKILKINPIPMLLGQIFASNIGGTMTMIGDPPNIMIGSAAHLSFLDFIENTGVACVIGLIAVIFAMKIAYKKKLKADAKAIKKVMELDENKAISDKRLLKISVVMILLIIIAFFFHDKLGIESGTVALTAGVVMLLIGRQDVEETIHDVEWPTILFFIGLFVCVGGLEATGFISQLGSLIMKVSGGHLVATMLILLWASALISAILNNVPFIATLIPLVLALGHQGMNITPLWWAISLGACLGGNGTQIGASANVVLSGIAGKNGYPISFSRYTKVGMPVMLITILIATGFLLLKFGHLS
>NC_015737.1|WP_013976512.1|597508_598060_+|hypothetical-protein
MKYTINPISDDLVNTVVRQLGAISVKTKSANVNVATFQLSENIRIKYKYEMKEDEPFYLQRISPYPLLIGTCETTDQLLAMLRKDLKMFQRAYKSSNFPEFLAIMTKLTEARRRTEDLFLHYNIPAESLTQIDQDLLAIFHGLRDAKRSAAPIAEPVFPDDDFLMEAPDPADTGDSVRERESN
>NC_015737.1|WP_013976513.1|598241_599240_-|branched-chain-amino-acid-ABC-transporter-permease
MKAKSHSKSSLIILVIVLLLLFVAVPVTGNAKLIDVLTLICLYLAMSQMWNLLGGYAGMLSLGMQAFIGIGGYSLTILSVKYTMNVYLSIIIGAVICGLFALAVSPAVFKMSGVYFAIGTWIVAEALTIFFSNWKFVGYAQDWSIGSVFLMSPTVLYLTALVVAVLATLVVYGLLRSKTGLALMAMRDSTSAAEVMGVELYKTKLKCYVIACTMMGLIGGAQYMKTAYINPSTGFSINWTIAMTFAVIIGGLGYMEGPIIGSILYVIITQIMYNYPGMSNIVLGIIAIVVIMAAPQGIMGFIYEHTGFLLLSPRRSIPDFEPSAPAKGEASK
>NC_015737.1|WP_013976514.1|599252_600119_-|branched-chain-amino-acid-ABC-transporter-permease
MLQVIITGILLGGLYSMIGVGMSLVFGIMGLTNLAHGDLMILGTYITLVITRAAGLPLVLATIISVIVMCVLGFVIQQFLVNQVMDKGEAPALLVTFGLSIFLSNLMLKIFSADNQSINNALTSKNVITTEYLTVSASYLMAFIIACVIIIGLSLFMKYTNYGRAIRATSDDTMAAELMGVNTKLAFAVAMVICMGITAVAGTLVGSTFTFYPSSGTQYLIIAFGVVVIGGMGSLFGTLVGGIILGVAQLVGGHIFGSGVQMLVAYIVLLVILATRPNGLFAASAVRK
>NC_015737.1|WP_041728267.1|600183_600897_-|ABC-transporter-ATP-binding-protein
MLEVNNIDVFYGDFHAIKDVSIHVEPGQIVSLIGANGAGKSTIMNTICGINHPKNGTIVFDGTDISHKKTNQIARLGLSMSPEGSHCFEKMTVQDNLLMGAYLAKGSERSSRLEQVYTLFPVLKEKKNQTATYLSGGQRQMLAIGRGIMTQPKILLLDEISLGLAPVVINDIYDRLQEIAATGLTMLVVEQNVNRSLSVADYAYVILEGRVVMQGKTSELNVDDVNDAYFGMNDFAS
>NC_015737.1|WP_013976516.1|600898_601630_-|ATP-binding-cassette-domain-containing-protein
MSAILSASGLGISFGSNHVLKDINFELGENEVLGVIGPNGAGKTVLLNILTGLLKPTKGQVVFNGKPIGDEGVTQRCRDGIGRTFQVPRPFEQMTVFENIMVGGVFGAGMSESQAKQKAIEVSKIIKLDDKLDLFAGKLALLDRKRLEIGRALATEPKVLLLDEVGGGLTESEVGLIINLVKEIKQRGVSVIWIEHIIRTMLEGTDRVMLLADGVDVITGKPLDVMNSPEVKRVYMGGGDDDE
>NC_015737.1|WP_013976517.1|601800_603069_-|ABC-transporter-substrate-binding-protein
MKKRISQLAALSLAGVMVVGLAACGSGSKGGGSAAKEGGSSGDTITVGFVYPKTGALAAFGAHSEDWTKYAIDVANKKGIKVDGKDVKLQLVAADSESSATKASEAANNLINAKKVDIMITSKTADTTVPVAAACERAGVVCLSVDTPDEAWATSDYKYAFHAGFNTKNELSAFKDAWDLGDTNKKVAVMHATDTEGQTMINAFSDFAKSNGYTAYDPGAYTSGATDYSSIISNIKSQKCEVVAGVMLTSDYGTFFKQLKSSGYMPKVITVAKATLFKADVDSIGANGLASGLCSEVWWRDDYPYKSSLDGMNCKDLGKKYIEVTGDSYAVPTAGYDYANIEILAAVINKAGSMDKDKLAAAAADLDLDTVIGKIKYNDKHYSVQALTTGQWIYKDGKWTQNIIANSQIPDAKTTADIQLLK
>NC_015737.1|WP_013976518.1|603323_604043_-|hypothetical-protein
MTQKETQLFAQEYDVGEPVIFALYRQQQEERVTVSLKYRFPSQGPEEITCRKIFYPLRAEDYESPYLSWYNLICCSNNYGPVPVVPYMNRAVQKGRKVAATIYPASAQEYMSILAEVEQKPDRYYCYPYHPQEYRYLLYLSRTGTLRDYFDLDRLLQIYSDCGIALDRGQMEEYFSRELNWFGREECPIPIHFCTGSEEFATVGLLFGYPVASTVALIARTMDLCEENRQERTEEISKS
>NC_015737.1|WP_013976519.1|604046_604694_-|GntR-family-transcriptional-regulator
MTKEDMIYEQIKQDILNNEFPAGTVLVERKLTERYQVSRSPVRYALRLLVKDGLLTGEPGKGIMVPVYTLEDILEVYDLLEVLQIYAIQMSLKNYDEAIDEEMSRILEETRKNTSEDRLDVRMQWDIRFHDCIIHNVHNRRLNSIFETLVNQKRRFDITSFHDVEHGKKTNDQHEQIFAALKARDMEGAIAAVRAHEAYIKQYYIEKLITGRYNI
>NC_015737.1|WP_013976520.1|604740_605304_-|flavodoxin-family-protein
MKKVVIFNGSPRFDGNTATICNMIERGAKEHNAQVNSYTLFKLKMSACQGCFGCRINDGKCSLNDELTKAIEQVKEADAVVIGSPIYFMQINGMVKNLYDRMFPLLGNDGRPRCGEKQIVTVYTQEMDDPHMHDSYFDFLAGTMFPGFGFVNEKRIVCTNANNPQSADDNRELMQQAYNVGREIANA

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Crispr_ID: NC_015737_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015737_2

780560-780656

Orphan

Consensus_repeat	Method
GCTGCTCCGTGCTCCGCACTCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_015737_2

>merge|NC_015737|2|780560-780656|CRISPRCasFinder
GCTGCTCCGTGCTCCGCACTCCCTCCCCCGCTCCATCCTCTGGCTGGGGCTTTTTCTCTAAATTAATTACACGGGATGCTCCGTGCTCCGCACTCCC

>NC_015737|2|2|780560-780656|CRISPRCasFinder
GCTGCTCCGTGCTCCGCACTCCC	TCCCCCGCTCCATCCTCTGGCTGGGGCTTTTTCTCTAAATTAATTACACGG
GATGCTCCGTGCTCCGCACTCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015737.1\|WP_013976674.1\|778579_779452_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_015737.1\|WP_013976678.1\|782923_784141_+\|FprA-family-A-type-flavoprotein	unknown	unknown	gnl\|CDD\|223503
NC_015737.1\|WP_013976684.1\|790118_791621_+\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|234594
NC_015737.1\|WP_013976672.1\|771987_772986_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133384
NC_015737.1\|WP_013976675.1\|779457_779817_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319900
NC_015737.1\|WP_041727593.1\|784639_785707_+\|J-domain-containing-protein	unknown	unknown	gnl\|CDD\|199909
NC_015737.1\|WP_013976676.1\|779888_780545_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_015737.1\|WP_013976677.1\|780933_782862_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NC_015737.1\|WP_013976673.1\|776141_778415_-\|glycogen/starch/alpha-glucan-phosphorylase	unknown	unknown	gnl\|CDD\|376320
NC_015737.1\|WP_013976681.1\|785869_786796_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_015737.1\|WP_013976682.1\|787004_788609_-\|phosphoenolpyruvate-carboxykinase-(ATP)	unknown	unknown	gnl\|CDD\|236471
NC_015737.1\|WP_148267778.1\|792810_793122_-\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013976671.1\|770874_771813_-\|Ig-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|349398
NC_015737.1\|WP_013976668.1\|766966_767974_-\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013976670.1\|769854_770148_-\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013976667.1\|766085_766970_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|318854
NC_015737.1\|WP_013976683.1\|788837_789821_-\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NC_015737.1\|WP_013976688.1\|793112_794156_+\|uroporphyrinogen-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|239548
NC_015737.1\|WP_013976669.1\|767975_769679_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227699
NC_015737.1\|WP_013976686.1\|792141_792714_-\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|226090

Protein	Function_ID	Function_description	E-value
NC_015737.1\|WP_013976674.1\|778579_779452_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	3.89478e-31
NC_015737.1\|WP_013976678.1\|782923_784141_+\|FprA-family-A-type-flavoprotein	gnl\|CDD\|223503	COG0426, FpaA, Uncharacterized flavoproteins [Energy production and conversion].	2.49827e-114
NC_015737.1\|WP_013976684.1\|790118_791621_+\|glycerol-kinase-GlpK	gnl\|CDD\|234594	PRK00047, glpK, glycerol kinase GlpK.	0
NC_015737.1\|WP_013976672.1\|771987_772986_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133384	cd01109, HTH_YyaN, Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB. Putative helix-turn-helix (HTH) MerR-like transcription regulators of Bacillus subtilis, YyaN and YraB, and related proteins; N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.65042e-21
NC_015737.1\|WP_013976675.1\|779457_779817_-\|VOC-family-protein	gnl\|CDD\|319900	cd07233, GlxI_Zn, Glyoxalase I that uses Zn(++) as cofactor. This family includes eukaryotic glyoxalase I that prefers the divalent cation zinc as cofactor. Glyoxalase I (also known as lactoylglutathione lyase; EC 4.4.1.5) is part of the glyoxalase system, a two-step system for detoxifying methylglyoxal, a side product of glycolysis. This system is responsible for the conversion of reactive, acyclic alpha-oxoaldehydes into the corresponding alpha-hydroxyacids and involves 2 enzymes, glyoxalase I and II. Glyoxalase I catalyses an intramolecular redox reaction of the hemithioacetal (formed from methylglyoxal and glutathione) to form the thioester, S-D-lactoylglutathione. This reaction involves the transfer of two hydrogen atoms from C1 to C2 of the methylglyoxal, and proceeds via an ene-diol intermediate. Glyoxalase I has a requirement for bound metal ions for catalysis. Eukaryotic glyoxalase I prefers the divalent cation zinc as cofactor, whereas Escherichia coil and other prokaryotic glyoxalase I uses nickel. However, eukaryotic Trypanosomatid parasites also use nickel as a cofactor, which could possibly be explained by acquiring their GLOI gene by horizontal gene transfer. Human glyoxalase I is a two-domain enzyme and it has the structure of a domain-swapped dimer with two active sites located at the dimer interface. In yeast, in various plants, insects and Plasmodia, glyoxalase I is four-domain, possibly the result of a further gene duplication and an additional gene fusing event.	3.97616e-28
NC_015737.1\|WP_041727593.1\|784639_785707_+\|J-domain-containing-protein	gnl\|CDD\|199909	cd10747, DnaJ_C, C-terminal substrate binding domain of DnaJ and HSP40. The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.	3.75637e-50
NC_015737.1\|WP_013976676.1\|779888_780545_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	5.16168e-21
NC_015737.1\|WP_013976677.1\|780933_782862_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
NC_015737.1\|WP_013976673.1\|776141_778415_-\|glycogen/starch/alpha-glucan-phosphorylase	gnl\|CDD\|376320	pfam00343, Phosphorylase, Carbohydrate phosphorylase. The members of this family catalyze the formation of glucose 1-phosphate from one of the following polyglucoses; glycogen, starch, glucan or maltodextrin.	0
NC_015737.1\|WP_013976681.1\|785869_786796_-\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.79445e-18
NC_015737.1\|WP_013976682.1\|787004_788609_-\|phosphoenolpyruvate-carboxykinase-(ATP)	gnl\|CDD\|236471	PRK09344, PRK09344, phosphoenolpyruvate carboxykinase.	0
NC_015737.1\|WP_013976671.1\|770874_771813_-\|Ig-like-domain-containing-protein	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	2.48976e-17
NC_015737.1\|WP_013976683.1\|788837_789821_-\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.0233e-68
NC_015737.1\|WP_013976667.1\|766085_766970_-\|hypothetical-protein	gnl\|CDD\|318854	pfam16731, GARP, Glutamic acid/alanine-rich protein of Trypanosoma. GARP, or glutamic acid/alanine-rich protein, is one of a subset of major surface molecules on Trypanosoma species. They are all surface-orientated, immunodominant, and highly charged. GARP is interesting as ts expression coincides with the loss and gain of variant surface glycoprotein (VSG) molecules in the tsetse vector. It has an extended helical bundle structure that is homologous to the core surface structure of VSG, suggesting that it might replace the bloodstream VSG as the trypanosomes differentiate inside the tsetse vector after a blood-meal.	0.00154355
NC_015737.1\|WP_013976688.1\|793112_794156_+\|uroporphyrinogen-decarboxylase-family-protein	gnl\|CDD\|239548	cd03465, URO-D_like, The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, an important branching point of the tetrapyrrole biosynthetic pathway. The methyltransferases represented here are important for ability of methanogenic organisms to use other compounds than carbon dioxide for reduction to methane.	1.5078e-56
NC_015737.1\|WP_013976669.1\|767975_769679_-\|hypothetical-protein	gnl\|CDD\|227699	COG5412, COG5412, Phage-related protein [Function unknown].	1.01248e-19
NC_015737.1\|WP_013976686.1\|792141_792714_-\|nitroreductase-family-protein	gnl\|CDD\|226090	COG3560, FMR2, Predicted oxidoreductase related to nitroreductase [General function prediction only].	1.62556e-78

>NC_015737.1|WP_013976676.1|779888_780545_-|Crp/Fnr-family-transcriptional-regulator
MKRREFLDDISKESLEQIIPCFLPKKKQYQRGSVILSYPDASNQPMHIGILETGAARLEVLGADGEMFQLEGFQQGDVFGEMFTLPLTNYEYIVTAEEDCRVIFLDYEHVITPCEHVCSHHTQMISNLFIMTAQKTQEMSFHLSVLNQRNTREKILCYLKYVRMMEDIAGDEEFRIPMTLSKLAEYLRVDRAAMTREIRGMKDEGMLESKNRWFRLLA
>NC_015737.1|WP_013976675.1|779457_779817_-|VOC-family-protein
MYFNHVKFTVRDLDKTVAFYQEALGLKPVERFDAPDGSFTNLYLGDGKTGFRLEITWNKGRTEPYDLGEECFHLALTSEDMEASHRHHEAMGCICFENPEMGIYFIKDPDGYWIEIVPE
>NC_015737.1|WP_013976674.1|778579_779452_+|AraC-family-transcriptional-regulator
MTLEEFSQYRETQLHEQPGFAYNTYLCTIPLDFPRVRLHWHEQTELIYIKKGSGTVSVNLIPYPVSAGCIVPVMPGELHAIEGSADGPMEYENIIFSLSILDSTAENDWCRQHILDPIRRASLQIPRPLRPGTDFHTEVARALDTADLACARRDPGFSLIVKSQLFLMLHAFYQYRIPAAVPEASSARTRVLKDVLEWIRLHYSEPVTVTDAAKAAGYSPSHFMRVFKAETGQTFISYLTDYRLTAASYYLTETRDPIGAIASRCGFDNFSYFIRLFRKRYGVSPRDYRK
>NC_015737.1|WP_013976673.1|776141_778415_-|glycogen/starch/alpha-glucan-phosphorylase
MSELNRIEFYTKKPIAECTDLELFNALLELTVDAATVRGYNTGKKKLYYISAEFLIGKLLSNNLINLQLYDQVSSELQAAGRSLEELEEFEYEPSLGNGGLGRLAACFLDSLATLGLPADGVGLAYHCGLFRQSFLNHKQYETPDYWLKWGRENWMRRTDRKYRVPFGGFSLESVMYEIAVTGYHGKCGRLRLFDVDSVDERSIKDGIAFDKESIAKNITLFLYPDDSDEQGRLLRVYQEYFMVSNAAQLMLEECEERGSNLHDLADYAAVQINDTHPTMVIPELIRLLTERGIDMDEAVQIVTDVCGYTNHTILAEALETWPKHYLEKAVPHLIPVIEALDARVRSKYEDSFVQIIDENQNVHMANIDIHFSHSVNGVAELHTNILKESELAPFYRIYPEKFNNKTNGITFRRWVRVCNPELSARITERIGHSWMHDSSELKKLLDLQDNTEFLDQLTEVKQQKKQQFADWIRNHQGAEVNPDTLFDVQSKRLHEYKRQQLNLLWIIRRYLDIKAGEKPEQPVTVIFGAKAAPAYTIAKDIIHAILCMSHIIARDPEVRKYLNVVMIENYNVTAAQNLIPAADLSEQISLASKEASGTGNMKYMINGALTIGTMDGANVEIADFVGPENIYTFGLSSDEVIAHYAKGDYCARDYYQADERLKEAVDFLTGPEMLETGDAENLNRLFHELVGKDWFMTFPDFAEYCKVKEQAIRDYAKKREWARRTLVNIANAGFFSSDRTIAQYNEDIWHLTSDRD
>NC_015737.1|WP_013976672.1|771987_772986_-|MerR-family-transcriptional-regulator
MKISEVCSKTGISKRSIHYYIQEGLISPVSNKHNGYFIFTEEDCRKLQTVRCLRNAGVSIADIRSIMANPATINYYLSIHLKKLRNELSLMQTTINSLNYILSKSPLHPSVSDILDLVSSAGIPDSSKTSVLDHFDSYDVSLTNKYLWGSFLNSEPFNDYQDFLWNKLQRLAQENYSDDYSKIEHYLCSLSNSSIDRTFAHTEQHHIYIAELTEKDYGSYSEQIKKQLHRISKNRVLVSAWKRNYDLFYAPTARIHSSQLGDIVAEISPFFASFKKNINEICKMVYDWLFRPEGSDCLALLNHTFGRCLDIQSCNHGQLESLASLSIIGYGE
>NC_015737.1|WP_013976671.1|770874_771813_-|Ig-like-domain-containing-protein
MEISAKKRWHRILVCLAAAVWSAVILCGIPGTTTTAWAAGTGKLKIKVAQDNGRAQEILKYVNKYRKQHHLSALKLDTELTEAAVTRGAELNIMVPYTSPHRRPDGRYAHTVNKRINYEDCLETTYGSISAKEIVDEWMDSPSHKKGILLPGARSIGIGAVYMQDSLFNGKLYPWYSYQQSYTLEISRTSVKKKLKSSSVKKYTKSISTKKSDLKKKYFSCTTKNVTLYTGNPSWDHSLELWVNYSGPHTWSDAHIDNSSFTWKSSKPSVASVNKHGLIKAVKPGTAAITFRLKSDPKVKLTVKVSVQKAGE
>NC_015737.1|WP_013976670.1|769854_770148_-|hypothetical-protein
MKLYETRAEAAQGCRASAKTAERYMKAAERFAREGRKTSAWNMADTAKTAADCAMQAHEALWGLADGKLTDEEFEAFEQAEIAQTNARKAAGAAANC
>NC_015737.1|WP_013976669.1|767975_769679_-|hypothetical-protein
MIVKIAVIAALVGPLLVGISKIGMAIGTISGGIGKMITLGGKLSKAFSDAGGMAGVMGKAIGFLTSPIGLVIAAIAAAIVVGVLLYKNWDKIKATAQKVFTAVSKIITSVMKTIKSVITTVWSGIKKFFVTVLTAIAAVFRAYFDIYLTIAKTVFKAIKIVITTIMNGIRVVIRTVWNAIKGIFSSVTGAIKSIVTRAWNGIKSVTSSVFHGVLSVTKSVWNRIKAVISSVVNAVRNVVSRGWHAIRSVTASVFNAVKNAMVHPIQTALSVIRGIVNRIKGLFHFSISMPHIPLPHFSISPSGWKIVATVKDGLGRFDTAYLPFEVHWAHQALIPTASVSVDKNNLIASITPIKPEGALDTDVCDIYRLSSDKPELIVSDAVFEETYVDPYPAFGDSCGHRVVMRTANGDYITAENIPAWTDYSDEDGDVLHETALVIDFDGDRAVLPYNVKLDHSWEKDFERTRYLGGSITGDWNEGVTRDLSVSTDIIRIQDSDLIQTMRRLADYAGICHVRTSDGSSFAADVEVSESREYNSLSVSFSLDIKKVEAEGFDGMTLSEWKELQEEV
>NC_015737.1|WP_013976668.1|766966_767974_-|hypothetical-protein
MDYSKGFTASYDLTIVDPVSWRDISHHRLTAGTITRNTDLLMESADLDLTEVPEDGEVWVRVWMNARQEYSSESRIPLFTGLTTAPERKLTGKRESYPASCYSVLKPAADRLLPRGWYAPKNGNGAKLVKDLLSVGAAPVTAAENASALSSAIVAEDGETNLSMASKILTATGWKIRIHGNGNITIQPKSTEVAVTFDAASFDILEPSVTDQYDWYSCPNVFRAVSGSDYAVARDEDPESRYSIASRGREIWMEETNCTLREGETLLSYAKRRLKEEQMPSRTISYDRRYVPDIFPGDLIRLNYPEEKISGTFEIRSQNITLGFAGKTSEEVIEV
>NC_015737.1|WP_013976667.1|766085_766970_-|hypothetical-protein
MNIKQHIAQRNLKEAFTYQGHSTKPYDTQATVTKAEDDIAWVHIPGGISETPVQRSIDAKVGDTVTLRVSGGSAWITGNLSSPPTDDTAANDAKEHAKEAKVTAVRAQGTADGAKNLADKAGSAAENAANAAGTAGTAAKQAAAQADQAKTDAASARNAANKVNVKFSSLIRKTDDGIECGMVPDASTLTDGNSVIVPAALVNTDGSFDVNLITYTNTSGTVSRTKSVRFASFGKEAVIGETNQTHARIDTDSFDIIDADGSIRASLGGATPLLQIGKFTFTNRENGNLTLQLN
>NC_015737.1|WP_013976677.1|780933_782862_+|acyl-CoA-dehydrogenase-family-protein
MLFQTSKEHEALRAEIRAFAEKEIAPIAFRLDKENEFPTEQVKQMAEHGWMGLPYPKEYGGAGADVISYAIAVEELARVDGGTGVILSAHTSLGTYPIAAYGTEEQKKKYLVPLASGQKLGAFGLTEENAGSDAGGTETTAIDKGDHYLLNGGKIFITNAPKADIYVVFAVTTPDIGTRGISAFIVEKGWKGFEFGDHYDKLGIRSSSTAELIFNNVKVPKENLLGKEGQGFKIAMSTLDGGRIGIAAQALGIAQGAYDKALEYAKERVQFGEPIGVHQGISFKLADMATKLQAARFLIYSAAELKENHERYGMEAAMAKMYASDAAVEITNDALQIFGGSGYLKGMEVERAFRDAKITTIYEGTNEIQRVVIAANLLGKISKNTGGGSRSVMKKPAPVTGIRKNRIFTEGEAADKVNDLVAALKSDGYDFSVGIPADTPIPQAERVVSAGKGIGDKANMKLIEDLAHAAGAAIGSSRPVAETLQYVPLNRYVGMSGQKFTGNLYIACGISGAKQHLKGIKDASTIVAINKNGNAPIFKNCDYGIVGDVNEILPLLTKALGTGKKAPAGKMIKMKRPLPPKPEPIGPRYICSGCAYEYIPELGDEEADIAPGTLFKDLPADWVCPECAEDKDHFIEAGIRGL
>NC_015737.1|WP_013976678.1|782923_784141_+|FprA-family-A-type-flavoprotein
MYNVRKITDDIYWCGANDHRLHLFENIHPIPQGVSYNCYLLLDEHPTLFDTVDWSACRQMIENLQYLLGDRPLEYLVINHLEPDHAACIEEILLIWPDVQLISTEKGFMLARQFGFSVDRQTCHTVKEGDTFSFGKHTVTFVEAPMVHWPEPMVTLDLTDGVLFSADAFGSFIANDGKMFADEVNYDRDYIDEARRYLVNIVGKYGPHVQLLLGKAASVLDKIKIIAPLHGLCWRKDLMYFINKYDLWSRYEPEEKGVLIVYASMYGNTESAAQALASRLCEKGVTNVKVCDVSNTHVSYLISDAFKYSHLVLASVTYNLNIYPVMFDFLDEMRMLNLQNRTVAIVENGSWACKSGDLMQKYIDENMKNMTILNERLSLASTLSADKSTELEQLADAIVESVQAE
>NC_015737.1|WP_041727593.1|784639_785707_+|J-domain-containing-protein
MPMTRNLYDVLGISKNASDNDIKKAYRKLARKYHPDANPGDRQAEARFKEIGEAYSILSDPEKKKLYDRFGSAPFEYGGDPKDYEKTHSGFFHGGADGTYGSSGFGNGGTRFYSSGPDGNGGYRTFHFEGGDAEDIFGDLFGNMFHGNNGRHDRSWSYRASSQGPDFDQFRSGFRNAGQPQSYDLHSDLTVSFDESVFGCSKKLRFQTEQGPQILEVTVPAGIQDGKSIRLRGKGRRRSNGSYGDLLLKVHVEEKAGYTRKGSDIYTSARIPFTTAVFGGEASLPTVYGPVKCKIPAGIQSGNKIRLKNKGTPVPGKPLEHGDEYVTIEIDVPKNLTPEQRRILREFQNASVPTA
>NC_015737.1|WP_013976681.1|785869_786796_-|DMT-family-transporter
MQLQTNRDLRKGHLAALVTILLWGTTYISTKILLKEFQPVEILLLRYVIALGVLFLLRPKRLKLQCRKHELYFALAGLTGVCMYYLLENIALTMTSASNVGVIGAVSPFFTAIFALFILKDPTARRPGFFIGFAVAIFGIGLITFQGAAMGFHLAGDLLVILSTMVWACYSVVSRIIGDFGYPTVQATRRMFLYGILFMLPFLKIFGFHPNLSALSEPVVLGNLIFLGVGASALCFVSWNYAVIRLGAVKTSVYIYLIPVVTVLAAVIVLHERITFWSGVGIVLTISGLFLSQGLRLKEKSGDTPESQ
>NC_015737.1|WP_013976682.1|787004_788609_-|phosphoenolpyruvate-carboxykinase-(ATP)
MGNIDLSQYGITGTTEIVYNPSYEQLFEEETRPELTGYDKGQVSELGAVNVMTGIYTGRSPKDKFIVMDENSKDTVWWTSEEYPNDNHPASEETWAAVKEIAREELSNKKLYVVDGFCGANKDTRMGIRFIMEVAWQAHFVKNMFIQPTPEEEASFTPDFVVYNASKAKVENYKELGLNSETAVVFNISSHEQVIINTWYGGEMKKGMFSMMNYYLPLKGVASMHCSANTDLNGENTAIFFGLSGTGKTTLSTDPKRLLIGDDEHGWDDSGVFNFEGGCYAKVINLDKDAEPDIYGAIRRNALLENVTLDADGKIDFADKSVTENTRVSYPIDHIEKIVKPISHGPAAENVIFLSADAFGVLPPISILTPEQTQYYFLSGFTAKLAGTERGITEPTPTFSACFGQAFLELHPTKYAQELVKKMKVSGARAYLVNTGWNGTGKRISIKDTRGIIDAILNGDVLKAPTKQIPYFNFEVPTELPGVDSRILDPRDTYAGPDEWNAKAKDLAGRFIRNFHKYEGNEAGKALISAGPQL
>NC_015737.1|WP_013976683.1|788837_789821_-|ADP-ribosylglycohydrolase-family-protein
MMRSIWYDGMMGLVTGDALGCPAEFCTREELRERGGVTAMEGYGTYQMPPGTWTDDSSMALATLDSLRNRQAAVPKDIMDCFAAWKAQGSYTPFGRAFDIGRTCSEAIEAYQKSGDWHTCGRTDEHANGNGALMRILPVCLFLIRQEQKKELDEEQALQTVQQVTALTHGHRRAGIASGLYYFMVRSIVQNREKGSLKELLQAGLDAGFRYYDKNPENQEELKHFARIRSLDAAEKIPEEKILSSGYVIDTIEAAVWCLLTTDSFRSCLLKAVNLGDDTDTTAAVAGGPAGLYYGGENIPAEWRNALQRREWIEGLIGAMDARDAEC
>NC_015737.1|WP_013976684.1|790118_791621_+|glycerol-kinase-GlpK
MADYIMALDAGTTSSRCILFDRSGRECGMAQQEFNQIFPQPGWVEHDPNEIWQTQLSVARKAMNQMHITFRDIAAIGIANQRETVILWDRRTGQPVCNAIVWQCRRTADDVERIKTEHPEYPQIFRDKTGLILDPYFSGTKIRWILDHVDGALEKAQRGDLCFGTVDSWLIYKLTKGRVHVTDYSNASRTLLFNIHTLSWDEELCNILEIPASILPEVKPSSCIYGETDPEFFGGPIPIAGAAGDQQAALFGQNCLRPGEAKNTYGTGCFTLMNIGNIPLLSASGLLTTIAWGLNNEITYALEGSVYVAGAAIQWLRDEMDLIDSSSDSEYFATRVPDTNGCYVVPAFTGLGAPYWDPYARGVITGLTRGVSKCHLIRATLESIAFQSYDVLHTMEADAGIRLRTLKVDGGASRNNFLMQFQADIANTEIQRPRCVETTALGAACLAGLAVSHWSCTEEITDNWTLDRAFLPQMSSDRRRRELAGWKKAVSASRGWAREY
>NC_015737.1|WP_013976686.1|792141_792714_-|nitroreductase-family-protein
MHLSDGLEKRRSYYQLNKELPVSADEVKQLLERVTELVPDSFNMKSARIVTALGSRQDELWDRIYDVFGGKVAREKIDGFKAAAGTILYFCDEDVVKAMQEQVPAYADNFPVWANQANGMLQFSIWTALRENGIGANLQHYNPVIDAVVKEMFDVPDSWKLIAQMPFGGIAAEPDPKAKEEIGERVRFFG
>NC_015737.1|WP_148267778.1|792810_793122_-|hypothetical-protein
MSSFLLPPIPLLSFLSEPLFLSIIEKGAVPHWKNIYADWQKFPGTQAQEKEKSRAVRLKKSKGSSRQTEAAQIFTKKQKKIAGAGKTAKENKYKNNNRIAKNG
>NC_015737.1|WP_013976688.1|793112_794156_+|uroporphyrinogen-decarboxylase-family-protein
MNSMERVLKALNHEEADRVPVYPLLAGVSRHLIGVNCKEWSTDAELCVKGLLKAKEDFDLDCIVTLIDLSLECDAWGQELVYPDNEPAHPNYKNQVIATEDDYDKIQYVDYRNSERMMMHIEVCRRLVEEAKGEYPVIAFVFGPLGILSMLRNQEEMYVDCIEQPETVYAATGRISQTLKDYCHAIMETGVQGIMFDTLFASGSIMSKEMWDELEGDWIEELSNQVREDGGLVMIHNCGGNIYFDAQIKRMQPAAISFLYPPDDCADLAETKEKYGDVTTLIGAVAPTTVTVGSPESIDAECRGNIDAMAKGGGFMLATGCELISPDAFAGARQMVEIAKTYGVYQH

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Crispr_ID: NC_015737_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015737_3

1014423-1014601

Orphan

Consensus_repeat	Method
TTATCGGTACATTTTGGGT	PILER-CR

3 spacers

The CRISPR arrays of NC_015737_3

>merge|NC_015737|3|1014423-1014601|PILER-CR
TTATCGGTACATTTTGGGTCATATAAAAAGAATCGCTTTCTGCCCGCTTCCGGTTTACCGGTACATTTTGGGTAAATTTTGACACCTCTTTCCGTACTAACTCTGTATTATCGGTACATTTCGGGTAAAATTTCGCAGCCTGTCCAGCATTTTCTCCGGATTATCGGTACATTTTCGGT

>NC_015737|3|1|1014423-1014601|PILER-CR
TTATCGGTACATTTTGGGT	CATATAAAAAGAATCGCTTTCTGCCCGCTTCCGGT
TTACCGGTACATTTTGGGT	AAATTTTGACACCTCTTTCCGTACTAACTCTGTA
TTATCGGTACATTTCGGGT	AAAATTTCGCAGCCTGTCCAGCATTTTCTCCGGA
TTATCGGTACATTTTCGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015737.1\|WP_013976892.1\|1021891_1022725_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|238269
NC_015737.1\|WP_013976893.1\|1022761_1024051_-\|homoserine-dehydrogenase	unknown	unknown	gnl\|CDD\|235783
NC_015737.1\|WP_013976877.1\|1004355_1004904_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153105
NC_015737.1\|WP_013976879.1\|1007872_1009057_-\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
NC_015737.1\|WP_013976882.1\|1010283_1011057_-\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|238635
NC_015737.1\|WP_070097184.1\|1020558_1020999_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NC_015737.1\|WP_013976885.1\|1012385_1013852_-\|replication-initiation-protein	unknown	unknown	gnl\|CDD\|376444
NC_015737.1\|WP_013976894.1\|1024573_1024930_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380433
NC_015737.1\|WP_041728430.1\|1002990_1003485_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|223663
NC_015737.1\|WP_013976876.1\|1003884_1004298_+\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|133478
NC_015737.1\|WP_013976881.1\|1009364_1010246_-\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NC_015737.1\|WP_013976880.1\|1009053_1009362_-\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198403
NC_015737.1\|WP_013976888.1\|1017467_1018826_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NC_015737.1\|WP_013976889.1\|1018964_1020248_-\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|200569
NC_015737.1\|WP_013976878.1\|1005059_1007876_-\|SMC-family-ATPase	unknown	unknown	gnl\|CDD\|223496
NC_015737.1\|WP_013976891.1\|1021049_1021871_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NC_015737.1\|WP_013976887.1\|1016387_1017353_+\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|225645
NC_015737.1\|WP_013976886.1\|1015402_1016227_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NC_015737.1\|WP_013976895.1\|1025068_1026793_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_015737.1\|WP_013976884.1\|1011295_1012240_+\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|181359

Protein	Function_ID	Function_description	E-value
NC_015737.1\|WP_013976892.1\|1021891_1022725_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|238269	cd00483, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.	3.09325e-59
NC_015737.1\|WP_013976893.1\|1022761_1024051_-\|homoserine-dehydrogenase	gnl\|CDD\|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	0
NC_015737.1\|WP_013976877.1\|1004355_1004904_+\|hypothetical-protein	gnl\|CDD\|153105	cd01046, Rubrerythrin_like, rubrerythrin-like, diiron-binding domain. Rubrerythrin-like domain, similar to rubrerythrin, a nonheme iron binding domain found in many air-sensitive bacteria and archaea, and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system. The rubrerythrin protein has two domains, a binuclear metal center located within a four-helix bundle of the rubrerythrin domain, and a rubredoxin domain. The Rubrerythrin-like domains in this CD are singular domains (no C-terminus rubredoxin domain) and are phylogenetically distinct from rubrerythrin domains of rubrerythrin-rubredoxin proteins.	2.89928e-51
NC_015737.1\|WP_013976879.1\|1007872_1009057_-\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	1.62127e-52
NC_015737.1\|WP_013976882.1\|1010283_1011057_-\|TatD-family-hydrolase	gnl\|CDD\|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	6.24223e-106
NC_015737.1\|WP_070097184.1\|1020558_1020999_+\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	2.83685e-09
NC_015737.1\|WP_013976885.1\|1012385_1013852_-\|replication-initiation-protein	gnl\|CDD\|376444	pfam01051, Rep_3, Initiator Replication protein. This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.	2.96135e-25
NC_015737.1\|WP_013976894.1\|1024573_1024930_-\|cupin-domain-containing-protein	gnl\|CDD\|380433	cd20299, cupin_YP766765-like, Rhizobium leguminosarum YP_766765.1 and related proteins, cupin domain. This family includes mostly bacterial proteins homologous to Rhizobium leguminosarum YP_766765.1, a protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.74368e-15
NC_015737.1\|WP_041728430.1\|1002990_1003485_-\|adenosine-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	7.24417e-60
NC_015737.1\|WP_013976876.1\|1003884_1004298_+\|transcriptional-repressor	gnl\|CDD\|133478	cd07153, Fur_like, Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators. Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.	6.47674e-41
NC_015737.1\|WP_013976881.1\|1009364_1010246_-\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	5.06971e-140
NC_015737.1\|WP_013976880.1\|1009053_1009362_-\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198403	cd10456, GIY-YIG_UPF0213, The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1. This family contains a group of uncharacterized proteins found mainly in bacteria and several in dsDNA viruses. Although their function roles have not been recognized, these proteins show significant sequence similarities with the N-terminal GIY-YIG endonuclease domain of structure-specific endonuclease subunit SLX1, which binds another structure-specific endonuclease subunit SLX4 to form an active heterodimeric SLX1-SLX4 complex. This complex functions as a 5' flap endonuclease in yeast, and has also been identified as a Holliday junction resolvase in human.	2.13119e-35
NC_015737.1\|WP_013976888.1\|1017467_1018826_-\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	9.65308e-24
NC_015737.1\|WP_013976889.1\|1018964_1020248_-\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|200569	cd10944, CE4_SmPgdA_like, Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins. This family is represented by a putative polysaccharide deacetylase PgdA from the oral pathogen Streptococcus mutans (SmPgdA) and Bacillus subtilis YheN (BsYheN), which are members of the carbohydrate esterase 4 (CE4) superfamily. SmPgdA is an extracellular metal-dependent polysaccharide deacetylase with a typical CE4 fold, with metal bound to a His-His-Asp triad. It possesses de-N-acetylase activity toward a hexamer of chitooligosaccharide N-acetylglucosamine, but not shorter chitooligosaccharides or a synthetic peptidoglycan tetrasaccharide. SmPgdA plays a role in tuning cell surface properties and in interactions with (salivary) agglutinin, an essential component of the innate immune system, most likely through deacetylation of an as-yet-unidentified polysaccharide. SmPgdA shows significant homology to the catalytic domains of peptidoglycan deacetylases from Streptococcus pneumoniae (SpPgdA) and Listeria monocytogenes (LmPgdA), both of which are involved in the bacterial defense mechanism against human mucosal lysozyme. The Bacillus subtilis genome contains six polysaccharide deacetylase gene homologs: pdaA, pdaB (previously known as ybaN), yheN, yjeA, yxkH and ylxY. The biological function of BsYheN is still unknown. This family also includes many uncharacterized polysaccharide deacetylases mainly found in bacteria.	6.97671e-77
NC_015737.1\|WP_013976878.1\|1005059_1007876_-\|SMC-family-ATPase	gnl\|CDD\|223496	COG0419, SbcC, ATPase involved in DNA repair [DNA replication, recombination, and repair].	3.82536e-68
NC_015737.1\|WP_013976891.1\|1021049_1021871_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	5.28134e-123
NC_015737.1\|WP_013976887.1\|1016387_1017353_+\|SH3-domain-containing-protein	gnl\|CDD\|225645	COG3103, COG3103, SH3 domain protein [Signal transduction mechanisms].	1.67783e-13
NC_015737.1\|WP_013976886.1\|1015402_1016227_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	2.71081e-49
NC_015737.1\|WP_013976895.1\|1025068_1026793_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_015737.1\|WP_013976884.1\|1011295_1012240_+\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|181359	PRK08293, PRK08293, 3-hydroxyacyl-CoA dehydrogenase.	3.23527e-172

>NC_015737.1|WP_013976885.1|1012385_1013852_-|replication-initiation-protein
MSDQQKTGKKKARKQDVVFKSSNAFLQAKYKSTLRQNKIFTYAISQMREKSDGNGGTDLVADLSAAEIKEQFGYTGNSVYNFLKPFSKDILDHKYMLEDDTTHQFFYMNMINDVSYSDGHLVITFNKKLKPHTLDVQKNYTLVDMRSLMSFESNNTFRLYELLKIYEYLIPKEEGACYEVKIGLAELKFNLGIIDAGDEKIEKAIKSGMSLEDIDDKIAVNAKYRDYSNFRKRVLDTAYKEMKASKKATIYFEYVPITRGRGRKTIAIRFFIYRHNNHDWHVESVFDTEVIDELSAYTEGRLSRKNITTLLEKSDGNAALIKTIYNSARETNGIKNLMGWMVSAIEGQWEFPERRTEENEEPAGTATRFTNFQERDTTDYDQLMAQLIHASDPQQTDASDPVDTEYEEISPVQEVTEPEEEEELPFGDLPDPKMADQPEEEHTEVHAPEEDAWLEKYKSMDKAAIFVELAKLPPDKQSQVIELLSHEN
>NC_015737.1|WP_013976884.1|1011295_1012240_+|3-hydroxyacyl-CoA-dehydrogenase
MSFKNVVVAGGGVLGSQIAYQSAFRGFHVTIWLRSEASIGRAKPKIDRLHSIYLDTLDACSKNPALTPRGFCEDPSKLTPEQFDKMKEAAEAAYNNMIYETDLAAAVADADLVIEAMAENPADKIAFYQNLAPVLEEKTILATNSSTLLPSTFAEYTGRPEKYLALHFANEIWKNNTAEIMGHPGTSPEAYQAVVSFAAEIGMVPLQLKKEQPGYILNSMLVPFLNSAQALYATGVADPETIDKTWMLATGAPAGPFRILDIVGLTTAYNIVMNRPEATSDPDSIPYKIAHKLKEYIDAGKTGVNAGEGFYRYK
>NC_015737.1|WP_013976882.1|1010283_1011057_-|TatD-family-hydrolase
MIFDTHAHYNDRQFDSDREELLASMKDHNVGTILNVGASVQDCRDTVELAHRWPMIYGAVGVHPDHTGELNEEIFAWLRETAGTDDRIVAIGEIGLDYHWNIESHETQKKWFIRQLELAGELDLPVSIHSRDAAQDTLEIMKTYGQGLTGSIHCFSYSPEIAEEYVKMGFCIGTGGVVTFKNAKKLKNTVARTPMEYLLLETDCPYLAPSPHRGERNHSIYLDFVADTVAQLKGISKEEVIRQTEANARRVFLKAKN
>NC_015737.1|WP_013976881.1|1009364_1010246_-|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MTEKKGIPYLGNPTRTRAVIERYGFTFQKKFGQNFLIDSNILEEIVEAAGITKTDYVLEIGPGIGTMTQYLAQAARAVTAVEIDDKLIPILENTLEEFPNAEIIHGDILKLDLNRLVEEKNNGNPIKVVANLPYYITTPIIMELFESRVPMESITIMVQKEVADRMQTGPGSKDYGALSLAVQYYAEPEIVAEVPPSCFMPQPKVGSAVIRLTRHRKPPVEVSDEKLLFAVIRASFNQRRKTLANGLKNAPELHFTKEQAETAIRNIGKPLTIRGEALTLQEFAQLSNQLGNL
>NC_015737.1|WP_013976880.1|1009053_1009362_-|GIY-YIG-nuclease-family-protein
MSENNYTYMLRCGDGSLYTGWTNHIRKRLTDHQSGRGAKYTRSHQPVELVYLEVYDTREEAMHREAVIKKLSRMKKLALIAEHPGWRTLMPPAETEQNGDGV
>NC_015737.1|WP_013976879.1|1007872_1009057_-|exonuclease-SbcCD-subunit-D
MRLIHLSDLHIGKKVNEFSMLEDQRYILKEILKITDSRHAEGVMISGDIYDKSVPPAEAVTLLDEFLTELSRRNLPVFIISGNHDSPQRLDFGSRLLASEKIYISGIFEKIPQPIVQTDAYGEIHFYLLPFIKPASVRHVLGQETEGTEEEGEEEEIRTYPDALAWVMEQIPVDPSVRNVLLAHQFVTGAVCSESEELYAGGQENVDAALFDAFDYVALGHIHRPQKIGRETVRYCGTPLKYSFSEASHVKSVTLVDLKKKGEVAVEQIPLTPRRDLREIRGTYEELTARSAYEGTAVEDYLHITLTDENDIMDAMNRLRTIYPNIMKLDYDNRRTRENREIRDLTESEHRSPMELLEDFYEQQNNQPMQEAQRKYLAARIEEIWDSRERTEHR
>NC_015737.1|WP_013976878.1|1005059_1007876_-|SMC-family-ATPase
MKPIKLTMSGFGPYADKQEIPFDRLEGCGLYLITGDTGAGKTTIFDAITYALYGEASGSSRDDARMFRSKYADAHTATYVELLFSYHGKKYTVRRNPEYERPKTRGQGTTRQAAGAVLEFSDGRPPVTKTQEVTRVITDLIGLDRVQFTQIAMIAQGDFLKLLLAKTEERSRIFRQIFHTEPYRQLQQKLHGDTAALKNAYERAEAVLAQTIARIHPDTEKEEEQLQALGLHQRKEREQLLEEMIHRDQKEADRLEQAYRDLDRRRNELQKEYSKAETDHRNREELRREEKILLEEQQKLFSAKAVLQKETEKDPEREQLRIQIAEEEKRLPEYEELTRIQSAGQKAEENRKKDQAGIAAEEARQEKQEKAYRQMLETRSSLKEVPQQLLREMHGLEQFQDREKLIRRISEQCRGIDREWKEIHTAREEYQKELEAYRRMHDREGRLNQQFLNAQAGLLAQTLTDGEPCPVCGSTVHPSAAELTREAPTEEMVSQAREQTAQQQERAGACSRRLGEMTARTGAHVRELAGNAARLFPELTEETWIQIFRKAEEQQTWPEEFTVRFRAVFDQNKTQKAEYQKRIQMYRQQKKELDALEQKIPESEDSLKQTQSRLEQWRQKQVRDQAEYENCRARLEECRRKLPFRSLQEARDQIIRQKAQLKQMTETRQQAEACYQECARAVDVRSGKTEALRKALEGSTPADRKELDTRRSDLEKEWNQLRDRQKTISLRLSENETVCKDLKMREKELTQLEEQQSWMMNLNATLNGTLSGKDKMMLETYIQTHYFDRVIGRANTRFMQMSSGQYELKRRREASNQRSQSGLELNVLDHHNGSERSVRTLSGGESFMASLSLALGLADEIQSTAGGIQLDTMFVDEGFGSLDEDTLNQAMRAFDDLSQSGRQIGIISHVSELKERIRNQIVVTKDVCGKSRARIVQE
>NC_015737.1|WP_013976877.1|1004355_1004904_+|hypothetical-protein
MAKFVCSVCGYVYEGDSLPADFTCPVCKAPASKFTEQKGEMEWAAEHVVGVAQGASEDIMADLRANFEGECSEVGMYLAMARVAHREGYPEIGLYYEKAAYEEAEHASKFAELLGEVITDSTKKNLEMRIDAENGATAGKTDLAKRAKAANLDAIHDTVHEMARDEARHGKAFLGLYNRYFK
>NC_015737.1|WP_013976876.1|1003884_1004298_+|transcriptional-repressor
MRNRSKRSKQRDSIQAFLASRHDHPTAETVYLNIREQIPNISLATVYRNLSLLSEQGEIRKISIGQGPDRFDGNTEPHSHFICRECGTIIDLAAEPALPVTDMDGHPFDGKIDEHVTCYYGLCPTCLKKTLPTGNIL
>NC_015737.1|WP_041728430.1|1002990_1003485_-|adenosine-deaminase
MKEAIRQAKKAKDLGEVPIGCVIVYEDRIIGRGYNRRNTDRSTLAHAELAAIRKACKKMGDWRLEGCTMYVTLEPCQMCSGALVQSRISKVVIGTMNPKAGCAGSVLNLLQMKAFNHQVDVEYGLCKEMCAEILRDFFRDLRRKNKEIRLQERKQKEIQSQELG
>NC_015737.1|WP_013976886.1|1015402_1016227_+|RNA-methyltransferase
MSVIRKVTDRNIPELKPYAAASDRQLMRYCEPEPGLFLAESAKVILRAWNAGYEPLSLLMDQNQTETESEELLHVLPDIPVFLTDWDTIKKITGLKMIRGALAIFRRKPLPDYLTIIQDARRIAVLDHVVNPSNIGAVFRSAAALNIDAVLLSRECSDPFYRRTLRVSMGTVFQIPWTKFSDNYSWPEEGLKQLKHLGFRTAAMALTENSVNVNDPALKNEKRLAILLGNEGYGLSEELTAACDYQVCIPMAHGVDSLNVAAASAVAFWELGNH
>NC_015737.1|WP_013976887.1|1016387_1017353_+|SH3-domain-containing-protein
MSMKKRILPAAAAAVFGLSCLMIPAPEAQAAGSVSRFVSSAIAIAKDNSHGYNDSNRWGPDYDCSSYIITALRNAGFNTNGATYTGNMRSALTGAGWSYYPASSMNLSGTSRLKSGDILIKSGHAEIYVGSGQRAGAHKNYDGRQGDSSGKEISVSSYYNGGWTGVLRYTGQSSSSGTASVRSAAVYSTGTYKTTINLNMRQKASISSKVLRNVKKGTKVSVTKVSGSWGKIKYSGKTGWVSFSYLKKMSTSSAASKAVKTGKYKTTINLNMRQKASISSKVLRNVKKGTKVSVTKISGSWGKIKYSGKTGWVALKYLKKA
>NC_015737.1|WP_013976888.1|1017467_1018826_-|alpha/beta-hydrolase
MVLLLAVLLIFTMLLVNQEKLMAFFCAAVMLFLGWGNLKSSPRLGIPGILNAAVEFFGASAGIAWILFTWYSGYCILLICGMFLLAKYTLQYMIRILRLPGQKTVIRILRTLPVLFLCVFYLMFHFSLLATAVTPLALVGPLQTYLNNTNSFSRKYDAGEFNFLHGEKVYSNVAYGTDYPNSFMDIYLSAEENADKPTVVFIHGGGYIGGTKTGGNPRSGSNGLLWYFTNLMQEGYNVVSIDYAYAPEYRYPIQLRQANQALAFLMRHGSKYGLHMDRVVLIGKSAGGNIAGMLALTATQPSSARKLQIRPALSQKNLKAVVFVSALINNEDFTITHNLIRDHVFMQYARCAFGTNVIRKSAIAKQTNLLTHVDENYPASYISDGNTATFYSQANALHKKLDQLGVVNELNLYPRKKERLGHGYETRPSLSCAQDNMKKTIAFLNRVVKANS
>NC_015737.1|WP_013976889.1|1018964_1020248_-|polysaccharide-deacetylase-family-protein
MSRRNTYGMPAWKRRREMRRRRNSLLGLIILVAVILIFFVAIPAHIHHKTVFQLKGDSDLTAEAGSSYTDPGIKVSYKGEDTYHGKKLSSRIKTENTIKKSTPGTYKVIYRMHIFTARFKAVRTVTVKDTTAPAITLSGGNSLSLNQGDSYKDPGYSAKDAVDGTVTNQVKVSGSVDTGKPGTYRITYKVTDKAGNEASAVRTVIVKAKVTPVTKSTIYLTFDDGPSSEVTPRILDILKKNDVKATFFIIGYGNDPVKKKLIRREIDEGHTIGMHTISHDYAAVYKSVGTFMSEINQEKANIQKDFNYTPWMIRFPGGSSNTISAHYCKGIMSQLSRKVEEAGYSYMDWNVSSGDAEGNEIPSDRLYRNYVRELVKGKENVVLCHDTNAKKTTAAVLQKFITYGKKHGYTFKAIDQSTPMIHQRINN
>NC_015737.1|WP_070097184.1|1020558_1020999_+|HD-domain-containing-protein
MDAIAADEKDRIYCGHNLQHALDVARIMRIYNGELALGISTDLIYAAALTHDIGRAVQYRTGIPHDRASAELAEQILPACGFDETETRQIAEAIRHHREYEKGSDISRTLGTLLCRADKESRLCFLCPAADTCKWPDTKKNHQLRI
>NC_015737.1|WP_013976891.1|1021049_1021871_+|dihydropteroate-synthase
MQIGRHAFDTEHHTYIMGILNVTPDSFSDGGRWNTLDHALEHTESMIQEGADLIDIGGESTRPGYTKISDEEEIHRVVPVIQAIRKRFDIPISVDTYKSKVAEAALEAGADLINDIWGLKYDPRMASVIAASGAACCLMHNRKNGQYSSFASDLKQDLLESVRLAETAGISRDKIILDPGIGFAKDYEQNLETMRILPELCRLPYPMLLGTSRKSMIGNCLHLPTEERLEGTLATTVLAVQAGCGFVRVHDIQANQRAIQMTEAILKRGVQKK
>NC_015737.1|WP_013976892.1|1021891_1022725_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MDRYLQEDKITIEGLTVFANHGVYPEEQSLGQKFTVSADLYVDTRKAAAADDLRQSVDYGLVCRHITEYLQKHTFQLIETAAGNTACDLLENFPLVRGVDLTLSKPWAPVGLPLENVSVTVRRRWHKVFLSLGSNLGSKKAYLDLAVEALDSLAGIRFRQISDYIVTRPYGNVPQDDFLNAAAEIDTWMSPEELLAQLHRIEQAAGRRREIHWGPRTLDLDILLYDSLVLDTPDLHIPHIDMENRDFVLVPLCQIAPYVRHPVLNRTAKQLLMDRNS
>NC_015737.1|WP_013976893.1|1022761_1024051_-|homoserine-dehydrogenase
MRKKINVGMLGIGNIGTGTYQALHMNHEKIAETTGLDIEIVKILNRHPEKDRGIDIPKEKYTPDPDEILTDPAIDIVVELIGGIEPATEYMAQALRNGKSVVTANKAAIAANGKLLADLAQENHVLLRFEAAVAGGIPILTSLTTALLSNRFTEVHGILNGTTNYILTQMGEYGKDYASVLKDAQEKGFAEADPTADVEGIDTANKLSILMSLIFGIGVGPDAIPTQGITSVGSDDIAFAEENGYKIKLLASARAKDGKVAGNVEPALVPDSHPLASVSNEFNAVFVTGNAVDDLMFYGRGAGPLPTGSAVVGDIIGIARKLEKDSAYDLVPQLRYDSELQYVGEGSNKYYVRMKARNHPGVMARITSVFGAHGISIETMVQKGSKDAEFVPLIFIFSYVEKTLLTEALQEILKDDCVSAVNSVMRVEE
>NC_015737.1|WP_013976894.1|1024573_1024930_-|cupin-domain-containing-protein
MAGYKITKKDGYYTYTAPGHNECKCTRLHDPQDVEGGQLINGLTHFLPAGGGTDFASNPCESIYYILHGTMKFKGEDEVETVLEAGDSVHIAANSPKCVTNIGPDTAQMLVVLLPPAK
>NC_015737.1|WP_013976895.1|1025068_1026793_-|ABC-transporter-ATP-binding-protein
MQTFRKFIQFYRPYKGVFIFDLICAAFISLVDLAYPQVLRTLTNTLFTRDPDRILHALPGIALVLLAAYILQALCKYYVSCQGHIMGAKMERDMRKKLFDQYEALSFSYYDRNNTGQMMSRLVSDLFDISEMAHHGPENLFISLVKIAGSFVFLFLIQKKLALLLLAVVILMTLVSAAQNRRMQATFLDNRRKIGSINATLQDSLSGIRIVQAFGNEKIEQAKFRRGNEAFLDSKRDNYRAMGTFQAGSLFFQGIMYLLVIAAGGYFVAKRQMSAGDLAMYSLYIGIFISPIQILVELTEMLQKGMSGFRRYLDVMETRREITDAPDAVPIADAHGDIVFQDVSFAYEAEEPVLIHLSFTVKSGESLALVGPSGGGKTTICSLIPRFYDVTGGTIRIGGQDIRKIRLESLRQSIGIVQQEVYMFSGTIRDNIAYGRPDASMEDIVEAAKKANVHEFVLSLPDGYDTFVGERGTRLSGGQKQRISIARIFLKNPPILILDEATSALDNESERYIQKSLDALAENRTTITIAHRLSTIRSADEILVIEGQGIAERGTHEELMEKNGIYARYYNLSK

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Crispr_ID: NC_015737_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015737_4

1046088-1046211

Orphan

Consensus_repeat	Method
AAATGTTTCACGTGAAACATTGC	PILER-CR

2 spacers

The CRISPR arrays of NC_015737_4

>merge|NC_015737|4|1046088-1046211|PILER-CR
AATGTTTCACGTGAAACCTCTCTGTTTTACGTGAACCAAAGAATGAAGAAAAAATGTTTCACGTGAAACATTTCAAAACAACCAAAACAAATTGGAAAATCAGATGTTTCACGTGAAACATTGC

>NC_015737|4|2|1046088-1046211|PILER-CR
AATGTTTCACGTGAAACCTCTCT	GTTTTACGTGAACCAAAGAATGAAGAAAAAATGT
TTCACGTGAAACATTTCAAAACA	ACCAAAACAAATTGGAAAATCAGATGT
TTCACGTGAAACATTGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015737.1\|WP_013976903.1\|1035803_1037150_-\|chromosomal-replication-initiator-protein-DnaA	unknown	unknown	gnl\|CDD\|273037
NC_015737.1\|WP_013976906.1\|1038070_1038337_+\|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl\|CDD\|376620
NC_015737.1\|WP_013976905.1\|1037667_1038030_+\|ribonuclease-P-protein-component	unknown	unknown	gnl\|CDD\|234782
NC_015737.1\|WP_013976904.1\|1037402_1037537_+\|50S-ribosomal-protein-L34	unknown	unknown	gnl\|CDD\|179004
NC_015737.1\|WP_013976921.1\|1052324_1053152_+\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293
NC_015737.1\|WP_013976916.1\|1048429_1048948_+\|DUF4446-family-protein	unknown	unknown	gnl\|CDD\|379655
NC_015737.1\|WP_013976923.1\|1054121_1054865_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_173363197.1\|1046232_1047039_+\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293
NC_015737.1\|WP_013976908.1\|1039702_1040323_+\|protein-jag	unknown	unknown	gnl\|CDD\|224760
NC_015737.1\|WP_013976909.1\|1040449_1041832_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NC_015737.1\|WP_148267851.1\|1051228_1051429_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013976907.1\|1038352_1039690_+\|YidC/Oxa1-family-membrane-protein-insertase	unknown	unknown	gnl\|CDD\|376730
NC_015737.1\|WP_013976912.1\|1044240_1044978_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NC_015737.1\|WP_013976911.1\|1041993_1043886_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	unknown	unknown	gnl\|CDD\|235362
NC_015737.1\|WP_013976922.1\|1053108_1054038_+\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|319264
NC_015737.1\|WP_013976918.1\|1050870_1051197_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013976920.1\|1051421_1052309_+\|replication-initiator-protein-A	unknown	unknown	gnl\|CDD\|369151
NC_015737.1\|WP_148267850.1\|1048954_1049839_+\|DUF3881-family-protein	unknown	unknown	gnl\|CDD\|379014
NC_015737.1\|WP_013976913.1\|1045003_1045951_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|178419
NC_015737.1\|WP_013976915.1\|1047040_1048363_+\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|275105

Protein	Function_ID	Function_description	E-value
NC_015737.1\|WP_013976903.1\|1035803_1037150_-\|chromosomal-replication-initiator-protein-DnaA	gnl\|CDD\|273037	TIGR00362, DnaA, chromosomal replication initiator protein DnaA. DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_015737.1\|WP_013976906.1\|1038070_1038337_+\|membrane-protein-insertion-efficiency-factor-YidD	gnl\|CDD\|376620	pfam01809, Haemolytic, Haemolytic domain. This domain has haemolytic activity. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	3.57676e-41
NC_015737.1\|WP_013976905.1\|1037667_1038030_+\|ribonuclease-P-protein-component	gnl\|CDD\|234782	PRK00499, rnpA, ribonuclease P; Reviewed.	2.80974e-45
NC_015737.1\|WP_013976904.1\|1037402_1037537_+\|50S-ribosomal-protein-L34	gnl\|CDD\|179004	PRK00399, rpmH, 50S ribosomal protein L34; Reviewed.	5.03296e-11
NC_015737.1\|WP_013976921.1\|1052324_1053152_+\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	1.12985e-72
NC_015737.1\|WP_013976916.1\|1048429_1048948_+\|DUF4446-family-protein	gnl\|CDD\|379655	pfam14584, DUF4446, Protein of unknown function (DUF4446). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 165 and 176 amino acids in length.	3.61306e-67
NC_015737.1\|WP_173363197.1\|1046232_1047039_+\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	1.03575e-99
NC_015737.1\|WP_013976908.1\|1039702_1040323_+\|protein-jag	gnl\|CDD\|224760	COG1847, Jag, Predicted RNA-binding protein [General function prediction only].	2.84702e-70
NC_015737.1\|WP_013976909.1\|1040449_1041832_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NC_015737.1\|WP_013976907.1\|1038352_1039690_+\|YidC/Oxa1-family-membrane-protein-insertase	gnl\|CDD\|376730	pfam02096, 60KD_IMP, 60Kd inner membrane protein.	1.36654e-28
NC_015737.1\|WP_013976912.1\|1044240_1044978_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	7.51497e-84
NC_015737.1\|WP_013976911.1\|1041993_1043886_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	gnl\|CDD\|235362	PRK05192, PRK05192, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG.	0
NC_015737.1\|WP_013976922.1\|1053108_1054038_+\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|319264	cd16407, ParB_N_like, ParB N-terminal, parA-binding, -like domain of bacterial and plasmid parABS partitioning systems. This family represents the N-terminal domain of ParB, a DNA-binding component of the prokaryotic parABS partitioning system. parABS contributes to the efficient segregation of chromosomes and low-copy number plasmids to daughter cells during prokaryotic cell division. The process includes the parA (Walker box) ATPase, the ParB DNA-binding protein and a parS cis-acting DNA sites. Binding of ParB to centromere-like parS sites is followed by non-specific binding to DNA ("spreading", which has been implicated in gene silencing in plasmid P1) and oligomerization of additional ParB molecules near the parS sites. It has been proposed that ParB-ParB cross-linking compacts the DNA, binds to parA via the N-terminal region, and leads to parA separating the ParB-parS complexes and the recruitment of the SMC (structural maintenance of chromosomes) complexes. The ParB N-terminal domain of Bacillus subtilis and other species contains a Arginine-rich ParB Box II with residues essential for bridging of the ParB-parS complexes. The arginine-rich ParB Box II consensus (I[VIL]AGERR[FYW]RA[AS] identified in several species is partially conserved with this family and related families. Mutations within the basic columns particularly debilitate spreading from the parS sites and impair SMC recruitment. The C-terminal domain contains a HTH DNA-binding motif and is the primary homo-dimerization domain, and binds to parS DNA sites. Additional homo-dimerization contacts are found along the N-terminal domain, but dimerization of the N-terminus may only occur after concentration at ParB-parS foci.	2.14514e-49
NC_015737.1\|WP_013976920.1\|1051421_1052309_+\|replication-initiator-protein-A	gnl\|CDD\|369151	pfam06970, RepA_N, Replication initiator protein A (RepA) N-terminus. This of family of predicted proteins represents the N-terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids. Most proteins in this family are bacterial, but archaeal and eukaryotic members are also included.	4.50032e-28
NC_015737.1\|WP_148267850.1\|1048954_1049839_+\|DUF3881-family-protein	gnl\|CDD\|379014	pfam12997, DUF3881, Domain of unknown function, E. rectale Gene description (DUF3881). Based on Eubacterium rectale gene EUBREC_3695. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture.	5.34635e-160
NC_015737.1\|WP_013976913.1\|1045003_1045951_-\|alpha/beta-hydrolase	gnl\|CDD\|178419	PLN02824, PLN02824, hydrolase, alpha/beta fold family protein.	1.08849e-11
NC_015737.1\|WP_013976915.1\|1047040_1048363_+\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	3.52179e-84

>NC_015737.1|WP_013976913.1|1045003_1045951_-|alpha/beta-hydrolase
MKKRIFSLFSTGSILGFAFLFNTFSGFRSVMGNRLSLKNGHYYRWKYGNVYYSKCGTGTPLLLIHELLPTSSGEEWAESLRTLAEAHTVYTLDLPGCGRSDKPDLLYTQYFYDQMIVDFISDIIQAPCDVMATGTSFSIAVMARKLDPSRFLHIIGVNPSPIEWTYRYPTVIHRLLRYILMSPFAGTFIYNVSHCKFLVTNDMVKNAFYEPAKLKKETVDLYYRFAHYDHHLNKMLFSSMLTRFMNLDIRDGIRQGENLSIIAGEADEQGVHAAKACARMNGSVRVRRIQKTKHLPQMENPGLFCMTAEKLLTHK
>NC_015737.1|WP_013976912.1|1044240_1044978_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MTYDLTKLQTSAAALGITLSEAQLAQFLTYYKMLIAWNEKMNLTAVTDFQEVLEKHFLDSLSLIQAVDLHAAAEKKPLRLIDVGTGAGFPGIPLKIAFPQLSVVLLDSLNKRIRFLHAVTEELGLTNITAIHGRSEELARSKEYRESFDLCVSRAVANLSTLSEYCLPFVRVGGLFLSYKGSEVDEEAETAEHAIHLLGGSIREIKRFSLPNTTYGRSLVVIQKKKNTPGKYPRKAGTPSREPLQ
>NC_015737.1|WP_013976911.1|1041993_1043886_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG
MPVLEENYDVVVVGAGHAGCEAALACARLGLETILFTVSVEAIAMMPCNPNIGGSSKGHLVREIDALGGEMGVNIDHTFIQSKMLNRSKGPAVHSLRAQADKAAYSARMRRTLQNTDHLTIRQSEVCELIVEDHTVRGVKTISGATYHARAVVLCTGTYLNARCLFGEVINQTGPNGLMAATHLTDSLKDNGVEMYRFKTGTPARIDKRSMDFSKMEEQKGDERVVPFSFTTDPESVQIDQVSCWLTYTNEETHRIIRENLDRSPMYSGVIEGTGPRYCPSIEDKVVKFADKKRHQIFIEPEGLDTNEMYLSGMSSSLPEDVQYAMYHSVPGLEHAKIVRNAYAIEYDCINPRQLRPSLEFKNIHGLFSGGQFNGSSGYEEAACQGLIAGINAAMQILGKDPLVLDRSESYIGVLIDDLVTKENHEPYRMMTSRSEYRLLLRQDNADLRLTPKGYKVGLISRERYEKVKEKERFIREEIARMETIKVGAGRQIGEFLSRLGSQPLHTSTSLAELIRRPELDYDKIAPLDPDRKPLPRDVIEQVTINIKYDGYIRRQMKQVKQFKRLEGKKLPAEFDYSTISGLRIEAQQKLNLYQPESIGQASRISGVSPADISVLLVYMEQLHQQEQTK
>NC_015737.1|WP_013976909.1|1040449_1041832_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MKTDTIAAIATAMAPAGIGIIRISGEESLEVADRIFRPIKSKKKVSQMDSHTVHYGYICDGEEIVDEVLLLVMRGPHTYTREDTVEIDTHGGVIVMKRILEVVLKNGARPAEPGEYTKRAFLNGRIDLTQAESVIDIINAKSDNALKSSVRQLQGSIRDKITDIRGRLLYELAFIESALDDPEHYTLDGYLPELKQKMQKIHSELKHLLDRADDGRILKEGINTVIVGKPNAGKSSLLNALTGEERAIVTDIAGTTRDTLQESIQLDGIGLNIVDTAGIRDTEDTVERIGVERSRQAMEDADLILYVADSSTPLDENDSEILQRIAGRRVIVLLNKSDLKEETSAEELRAHLDPDQEVIPVSMVDGTGLQQFRDRVKDMFFHGNLSFNDEVYLTNARQKNTLTLAWESIGQVLQSMENQMPEDFLTIDMMDAYQELGKMIGEAVEDDLVDEIFSEFCMGK
>NC_015737.1|WP_013976908.1|1039702_1040323_+|protein-jag
MDYIEVSGKTVEEALTEATVQLGTTSDQIEYEVLDKGASGFLGFNSKPAVIRARRKFSPEDRIRDFLSQVFAAMHLDVEIIFHNTEDDCIDVELKGDDMGILIGKRGQTLDALQYLTNLSLNKHSDHYTKVRIDTEDYRHRRQQTLENLAKNIAYKVKRTRKDVSLEPMNPFERRIIHCALQDDKYVETHSEGEEPYRFVVVTLKK
>NC_015737.1|WP_013976907.1|1038352_1039690_+|YidC/Oxa1-family-membrane-protein-insertase
MGLLLTQSSGVLRPIAVALGWLMNLIYIGLSKIGINNVALTIIVFTILIYLCMMPLTYQQQKFSKMTMIMNPELQAIQKKYRGKRDQASVNAMNEETQAVYRKYGVSPSGSCIYLVIQLPILFALYRVIYNVPAYISSVKNTFTDLAAQVYATSGAHGTMTKFLDSIQTYAMRGVKLDWSSATAAKDSIIDVLYKCTSSNWDLFRDTFPNISSGLISTTQAKAEAFNSFLGVSVVYSPKNIIATSFHEGHYLLILIAILIPVISAATQFINIRLMPTSAGAGAGGMGGQMKAMNYMMPIYSFILVFFLPVGVGVYWIAGALIRSFQQWFFNRRLDRMDMDEMIKKNRAKAEEKEKKRLEKKSGVSGQTISKSANISTKKIDTSSANIKKNSMAAKANAVKHSNKNNKTDSPETETQQDAPVTYKKGSLTSKANLVKDFNNRNTKK
>NC_015737.1|WP_013976906.1|1038070_1038337_+|membrane-protein-insertion-efficiency-factor-YidD
MKKVFIKLIKLYQKYISPMKTVKCPYYPTCSAYGLEAVETHGALKGGLLAAWRILRCNPFSKGGYDPVPEPKKKTNKIKSLVKEEIRF
>NC_015737.1|WP_013976905.1|1037667_1038030_+|ribonuclease-P-protein-component
MRFSESLKKNQDFRLVYRKGKSYANRILVMYVLKNGTESNRLGISVSKKVGNSVVRHRITRLVRESYRLSENMFHPGWDMVVVARGSAKAADYRAIESALLHLAGMHHILDLQEKGRMRP
>NC_015737.1|WP_013976904.1|1037402_1037537_+|50S-ribosomal-protein-L34
MKMTYQPKKRQRSKVHGFRARMSTKGGRKVLASRRAKGRKKLSA
>NC_015737.1|WP_013976903.1|1035803_1037150_-|chromosomal-replication-initiator-protein-DnaA
MLSIEENWDKILQKTKKDYDLTDVVYRSWLKPLEVFSVEGSKITILVPIEPIALNIVEKKYKKLIQVTIEEMTGTAYELEFILPEDTRSRKPRIRRELPVNEAASKCNLNPNYTFDTFVVGSNNRLAHSAALAVAENPGDKTYNPLFIYGGVGLGKTHLMHSIAHYILDQDPSKKVLYVSSETFMNDVIEGIRTHTTASLREKYRKLDVLLVDDIQFISKSDATQEEFFNTFNDLRSINHQIIISSDRQPKELEKLEERAKSRLAWGIQVDIASPDYETRMAILRNKVKLEAIDLDEEILNYIAINIKSNIRELEGALNKLIAYSNLERADITMDIAVRELESLIYPEANREITPSLITEVVCDHFGLTVEQILSSDRSRSIARPRQIIMYLCKSMTDLPLDAIGREIGGRDHSTVLHGVNKISREYREDETLHQSIDAIRKKINPHV
>NC_015737.1|WP_173363197.1|1046232_1047039_+|ParA-family-protein
MLYYKISFGKENRLKRIIAIANQKGGVGKTTTSINLAACIAEQGKKVLLVDLDPQGNATTGVGLDKNEIEFSTYELLIGECTAKKAAVSTNTENLDIIPANMNLAASEIELVETKNKEYRLKEELDYIVDDYDFVIIDCPPSLSMLTINAMTTADTVLVPIQCEYYALEGLSQLMYTINLIQERLNENLKVEGIVFTMYDSRTNLSNDVITNVKKYMDTYIYETLIPRNIRLAEAPSYGMPINQYDDRSTGAAAYRALATEVIEREDI
>NC_015737.1|WP_013976915.1|1047040_1048363_+|ParB/RepB/Spo0J-family-partition-protein
MAARRRGLGSGLDALIPPKRNRTEEKKTGHSDHTEDTAGQAGPAQEKKSAEAKSTKQEEKSAEVKTAKQTKKSAGVKTGEQKKSSAGAKATGQEENTARIKSTKQKANTAEEKSSEQEANTAEEKLPKQKEKSAQDDVSVKGKSAVSQTDKASASVPKEEKSAAKKETESTAGSKGKETTVPIDRVEPNRNQPRKEFDRESLKELADSISEYGILQPLLVTDKKDYYQIIAGERRWRAAKLAGLKEVPVIVRELTDQEIVEISLIENIQREDLNPIEEAHAYRTLIEEFQLKQSDVAKRVSKSRTVITNSMRLLKLDQKVQQMLIDGKLSVGHARALIALEDPALQVEVAEQTAEKKLSVREVEQLIRSLLHPKKTKEKKKESPELEHLYRDLEEQMKLVLGTKVEIKNKGKQGKIEISYFSQEELDHILLMLKSIDQDI
>NC_015737.1|WP_013976916.1|1048429_1048948_+|DUF4446-family-protein
MSGILDLSLKSLTGISADFMVLVLAALVVILIIVCCVLAGRSRKLRAAYEKFMRGHDGQSLEGVLKSQLDHLDQVRMEEKQAENKVHEIMDEFDDTYQKMGLVKYDAFDEMGGKLSFSLAMLNRKNTGFVLNAVHSKEGCYTYIKEIIEGNSVLLLAQEEKEAVEMAMHSQE
>NC_015737.1|WP_148267850.1|1048954_1049839_+|DUF3881-family-protein
MHNFLRSIGFHNLQKNTELFDILEDIVRNPDRKSVTRDIYGNGFGSFSREYGENFGITVCGDFLENNEFHIEYYFPFFRGSDISTYEQIEVERFAQKEAYAGICDDLRLGATLIFYIDNVADLLNARLLYGNQFNASNAVLSGLASSGKILLPVLKTEQQVKQRTEISKKRMDLLNEAKSGSQEAIDSLTLNDMDTYSMLSQRVNHNKEDILSIVESSFIPYGIESDQYVVIGEILSCRRTHNQTTNESVWILGLDCNDLVFDIIINERDLYGEPAVGRRFRGRILMQGFINFS
>NC_015737.1|WP_013976918.1|1050870_1051197_+|hypothetical-protein
MRTRQKLQRKTIMIDGVRYYAERPHDCRKCFFWKNRKVGCSLGKENCYYLAEVIKTEQEKKCENCPYAKGQPCVTASCYKDLEHWLQERRARTVKLMMKEERSSAYVG
>NC_015737.1|WP_148267851.1|1051228_1051429_+|hypothetical-protein
MIKKARKTGIGEKPPSCAKCQYYQPEFKYRKCLYARCPYQRDTEIFRKRPLKKDKIPGPEVVKVDG
>NC_015737.1|WP_013976920.1|1051421_1052309_+|replication-initiator-protein-A
MDNYYLDYFYGLEADAYSFIRVPKLLINLPIYKDLTSDDKLLYGILLDRMSLSAKNRWMDDDGRVYIIFTIEDVMEALNCAQHKAVKLMNNLETKAHLIERKRQGQGKPSLIYVKKFVPMSNAQFLNCQNRNSGIAESTIQELPKPQCNNTESNNTEYSDTDLFFSADGRSEEMRTRAAYEEYFREALEIDFLKQNNPGERDTLDGILDLIVDTCCANKPWIVISGDKKPIEVVKSRFMKLNSSHIEYVLKCLSDNTTRIRNVNQYLLATLFNATTTISPYYRSWVNNDMANGLV
>NC_015737.1|WP_013976921.1|1052324_1053152_+|ParA-family-protein
MPNKATVLCCGNQKGGVGKTFTTENLGVGLAQEGKKVLLVDMDPQASLTISLGHPRPDELPVTISDMMQKVITDEDIQLREGILTHPEGVDLMPANISLSGLEVSLVNAMSRESILKQYLEALKKNYEFIILDCMPSLGMLTVNALAASDQLIVPVQAQYLSAKGLEQLLQTVNKVKRQINPKLRIEGILLTMVDARTNNAKEIAGLIRETYGSRLKVFDVEIPRSVRAAEISAEGKSIFAHDPGGKVAAAYKELTKEVIRDAEKRRKHHLEQLR
>NC_015737.1|WP_013976922.1|1053108_1054038_+|ParB/RepB/Spo0J-family-partition-protein
MPKKGANITLSSYDDIFETDESRADAQLERIQKIPISELVPFRDHPFKVVDDEAMLRTTESIAQFGVLTPLIARPLEDGTYEIISGHRRVHAAQAAGLTEVPVIVRDMDDDAATVLMVDSNLQREHILPSERAFAYKMKNEAMKRRAGRPSRENASQVGTQKRTDEIMVEEMGQSRNQIQRYIRLTYLIPELLELVDEKKISFNPAVELSYLKPTEQEMFLSVMEWSQNAPSLSQAQRLKKLSQDGKLTPDAMREIMNEVKKGDLERVTFRNETLRKYFPRSYTAQQMQDQIIKLLEQWQKRKQRNQER
>NC_015737.1|WP_013976923.1|1054121_1054865_+|hypothetical-protein
MSKMKATEKQAMEILKKLDELIDFSVDLEANLDESETIEEVLLCLEDTIDEFCDAVEVIEAIREFLIEVENLDDEDPAEEEPEEECTCCAPPELRNELIRIAQSIQAYERMAAEKRMAGTATKRNPVPEIPVPEEDSVALLFYDAGDYRVFPFEHVLRICPWLNEHSVMRAIPGVKDLYYLYEEGTEIKTESDLYLVGPVVVIRLNKDHFLITPDALDRHRVRKFMRDNTETIDFEEGASYPALRFV

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Crispr_ID: NC_015737_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015737_5

1391183-1391277

Orphan

Consensus_repeat	Method
CGCCGGATTTTTTGCTGTGCCGCCGGATTTTT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_015737_5

>merge|NC_015737|5|1391183-1391277|CRISPRCasFinder
CGCCGGATTTTTTGCTGTGCCGCCGGATTTTTTGCTGTGCCGCTGGATTTTTATCGCTTCTGCCGCCGGATTTTTTGCTGTGCCGCTGGATTTTT

>NC_015737|5|3|1391183-1391277|CRISPRCasFinder
CGCCGGATTTTTTGCTGTGCCGCCGGATTTTT	TGCTGTGCCGCTGGATTTTTATCGCTTCTGC
CGCCGGATTTTTTGCTGTGCCGCTGGATTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_015737.1\|WP_083835061.1\|1385593_1387546_+\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319847
NC_015737.1\|WP_013977221.1\|1382129_1383773_+\|Na/Pi-cotransporter-family-protein	unknown	unknown	gnl\|CDD\|224202
NC_015737.1\|WP_013977242.1\|1405058_1405712_+\|DUF308-domain-containing-protein	unknown	unknown	gnl\|CDD\|225786
NC_015737.1\|WP_083835062.1\|1402253_1402907_+\|sortase	unknown	unknown	gnl\|CDD\|320674
NC_015737.1\|WP_013977234.1\|1394215_1398814_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|379234
NC_015737.1\|WP_013977237.1\|1401409_1402096_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380024
NC_015737.1\|WP_013977229.1\|1390870_1391020_+\|FeoB-associated-Cys-rich-membrane-protein	unknown	unknown	gnl\|CDD\|378908
NC_015737.1\|WP_013977227.1\|1388283_1388505_+\|ferrous-iron-transport-protein-A	unknown	unknown	gnl\|CDD\|224830
NC_015737.1\|WP_013977241.1\|1404524_1405004_+\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NC_015737.1\|WP_013977228.1\|1388596_1390789_+\|ferrous-iron-transport-protein-B	unknown	unknown	gnl\|CDD\|223447
NC_015737.1\|WP_013977220.1\|1381174_1381624_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107228
NC_015737.1\|WP_148267796.1\|1400480_1401413_+\|class-C-sortase	unknown	unknown	gnl\|CDD\|320676
NC_015737.1\|WP_013977233.1\|1393468_1394131_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_015737.1\|WP_013977226.1\|1388024_1388234_+\|ferrous-iron-transport-protein-A	unknown	unknown	gnl\|CDD\|377199
NC_015737.1\|WP_013977230.1\|1391392_1392544_+\|ATPase	unknown	unknown	gnl\|CDD\|236737
NC_015737.1\|WP_041727686.1\|1398905_1400318_+\|SpaH/EbpB-family-LPXTG-anchored-major-pilin	unknown	unknown	gnl\|CDD\|275067
NC_015737.1\|WP_013977224.1\|1385186_1385405_+\|cation-transporter	unknown	unknown	gnl\|CDD\|236827
NC_015737.1\|WP_083834972.1\|1384784_1385138_+\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NC_015737.1\|WP_013977222.1\|1383865_1384639_-\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_148267797.1\|1403054_1404224_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353

Protein	Function_ID	Function_description	E-value
NC_015737.1\|WP_083835061.1\|1385593_1387546_+\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319847	cd07548, P-type_ATPase-Cd_Zn_Co_like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell. Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_015737.1\|WP_013977221.1\|1382129_1383773_+\|Na/Pi-cotransporter-family-protein	gnl\|CDD\|224202	COG1283, NptA, Na+/phosphate symporter [Inorganic ion transport and metabolism].	3.78775e-115
NC_015737.1\|WP_013977242.1\|1405058_1405712_+\|DUF308-domain-containing-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	1.45118e-06
NC_015737.1\|WP_083835062.1\|1402253_1402907_+\|sortase	gnl\|CDD\|320674	cd00004, Sortase, Sortase domain. Sortases are cysteine transpeptidases, mainly found in Gram-positive bacteria, which either anchor surface proteins to peptidoglycans of the bacterial cell wall envelope or link proteins together to form pili by working alone, or in concert with other enzymes. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall sorting signal and covalently linked to peptidoglycan for display on the bacterial surface. Sortases are grouped into different classes based on sequence, membrane topology, genomic positioning, and cleavage site preference. The different classes are called class A to F sortases. Most Gram-positive bacteria contain more than one sortase and it is thought that the different sortases attach different surface protein classes. The typical eight-stranded beta-barrel fold is observed in all known sortases, along with the conserved catalytic triad consisting of cysteine, histidine and arginine residues. Some sortases contain an N-terminal signal peptide only and the C-terminus serves as a membrane anchor, which represents a type I membrane topology, with the N-terminal enzymatic portion projecting towards the bacterial surface and the C-terminal end residing in the cytoplasm. Other sortases adopt a type II membrane topology, with the N-terminal hydrophobic segment inside the cytoplasm and the C-terminal enzymatic portion located across the plasma membrane. The N-terminus either functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. Sortases are also present in some Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	6.9629e-37
NC_015737.1\|WP_013977234.1\|1394215_1398814_+\|VWA-domain-containing-protein	gnl\|CDD\|379234	pfam13519, VWA_2, von Willebrand factor type A domain.	9.41357e-14
NC_015737.1\|WP_013977237.1\|1401409_1402096_+\|hypothetical-protein	gnl\|CDD\|380024	pfam17802, SpaA, Prealbumin-like fold domain. This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.	2.32354e-06
NC_015737.1\|WP_013977229.1\|1390870_1391020_+\|FeoB-associated-Cys-rich-membrane-protein	gnl\|CDD\|378908	pfam12669, P12, Virus attachment protein p12 family. This family of proteins are related to Virus attachment protein p12 from the African swine fever virus. The family appears to contain an N-terminal signal peptide followed by a short cysteine rich region. The cysteine rich region is extremely variable and it is possible that only the N-terminal region is homologous.	0.000108254
NC_015737.1\|WP_013977227.1\|1388283_1388505_+\|ferrous-iron-transport-protein-A	gnl\|CDD\|224830	COG1918, FeoA, Fe2+ transport system protein A [Inorganic ion transport and metabolism].	5.51905e-18
NC_015737.1\|WP_013977241.1\|1404524_1405004_+\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	1.44044e-76
NC_015737.1\|WP_013977228.1\|1388596_1390789_+\|ferrous-iron-transport-protein-B	gnl\|CDD\|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	0
NC_015737.1\|WP_013977220.1\|1381174_1381624_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107228	cd06471, ACD_LpsHSP_like, Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Transcription of the genes encoding Lp HSP 18.5, 18.55 and 19.3 is regulated by a variety of stresses including heat, cold and ethanol. Early growing L. plantarum cells contain elevated levels of these mRNAs which rapidly fall of as the cells enter stationary phase. Also belonging to this group is Bifidobacterium breve (Bb) HSP20 and Oenococcus oenis (syn. Leuconostoc oenos) (Oo) HSP18. Transcription of the gene encoding BbHSP20 is strongly induced following heat or osmotic shock, and that of the gene encoding OoHSP18 following heat, ethanol or acid shock. OoHSP18 is peripherally associated with the cytoplasmic membrane.	5.37165e-43
NC_015737.1\|WP_148267796.1\|1400480_1401413_+\|class-C-sortase	gnl\|CDD\|320676	cd05827, Sortase_C, Sortase domain found in class C sortases. Class C sortases are membrane-bound cysteine transpeptidases broadly distributed in Gram-positive bacteria (mainly present in Firmicutes and Actinobacteria). They function as pilin polymerases responsible for the assembly of pili, which are multi-subunit hair-like fibres that extend from the cell surface to promote microbial adhesion and biofilm formation. First, one or more class C sortases form the long thin shaft of the pilus through linking together pilin subunits via isopeptide bonds. The base of the pilus is then anchored to the cell wall by a housekeeping sortase or, in some cases, the class C sortase itself. Depending upon the organism both the number and type of sortase enzymes involved varies, and in some cases, accessory factors appear to be needed. In three-component spaA pilus from Corynebacterium diphtheriae, the prototypical class C sortase (named Cd-SrtA) catalyzes polymerization of the SpaA-type pilus, consisting of the shaft pilin SpaA, tip pilin SpaC and minor pilin SpaB. The pilus shaft is then attached to the cell wall by a housekeeping class E sortase, Cd-SrtF. In the absence of Cd-SrtF, Cd-SrtA attaches the pilus to the cell wall, albeit at a reduced rate. Cd-SrtA can recognize two distinct sorting signals (LPLTG in SpaA and SpaC, and LAFTG in SpaB) and it can employ lysine residues that originate from different proteins (either Lys190 within the pilin motif of SpaA or Lys139 in SpaB). However, Cd-SrtA cannot be able to polymerize the major pilin subunit SpaH, even though it contains LPLTG motif. In two-component pili of prototypical Bacillus cereus, the class C sortase (named Bc-SrtD) cleaves related sorting signals within a major pilin protein BcpA (LPVTG) and a minor tip pilin BcpB (IPNTG), and catalyzes a transpeptidation that joins the threonine residues in each signal to the side-chain of Lys162 in BcpA (located within a pilin motif). Unlike the SpaA pilus in C. diphtheriae, in B. cereus Bc-SrtD is unable to covalently attach the pilus to the cell wall without the help of the housekeeping sortase.	4.00176e-83
NC_015737.1\|WP_013977233.1\|1393468_1394131_+\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.42453e-35
NC_015737.1\|WP_013977226.1\|1388024_1388234_+\|ferrous-iron-transport-protein-A	gnl\|CDD\|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	1.50771e-15
NC_015737.1\|WP_013977230.1\|1391392_1392544_+\|ATPase	gnl\|CDD\|236737	PRK10696, PRK10696, tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional.	5.9971e-59
NC_015737.1\|WP_041727686.1\|1398905_1400318_+\|SpaH/EbpB-family-LPXTG-anchored-major-pilin	gnl\|CDD\|275067	TIGR04226, Fimbrial_subunit_type_2, fimbrial isopeptide formation D2 domain. The Streptococcus Pneumoniae pilus backbone protein, RrgB, has three tandem domains with Lys-to-Asn isopeptide bonds, but these three regions are extremely divergent in sequence. This model represents the homology domain family of the D2 domain. It occurs just once in many surface proteins but up to twenty times in some pilin subunit proteins. Three of every four members have the typical Gram-positive C-terminal motif, LPXTG, although in many cases this motif may be involved in pilin subunit cross-linking rather than cell wall attachment. Proteins with this domain include fimbrial proteins with lectin-like adhesion functions, and the majority of characterized members are involved in surface adhesion to host structures.	3.36127e-13
NC_015737.1\|WP_013977224.1\|1385186_1385405_+\|cation-transporter	gnl\|CDD\|236827	PRK11033, zntA, zinc/cadmium/mercury/lead-transporting ATPase; Provisional.	3.21935e-11
NC_015737.1\|WP_083834972.1\|1384784_1385138_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	1.02404e-16
NC_015737.1\|WP_148267797.1\|1403054_1404224_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	5.87331e-14

>NC_015737.1|WP_013977229.1|1390870_1391020_+|FeoB-associated-Cys-rich-membrane-protein
MAGTIIIAAALAAAVTLIIRSMIKDRKAGKSLQCGMNCSECRKGGGCCH
>NC_015737.1|WP_013977228.1|1388596_1390789_+|ferrous-iron-transport-protein-B
MSIRIALAGNPNSGKTTLFNALTGSNQYVGNWPGVTVEKKEGRLKSDRQVKIGDTPGIYSLSPYTLEEVVARNYLLQERPEVILNIIDGTNIERNLYLTTQLMELGIPVILAVNMMDAVEKNGDTIDMKKLGDAFGTVAVPISALKGTGIQKAAQLAMETAKKHKVYHCRHHFSEPVEAAIEQVEGAIGTAVPEEQKRFFAIKLLENDEKIREEYAGLPDVSEEIETLEKAFDDDVESIIANERYQVVSDVIDGCLTRRNKEKLTVSDRIDRVVTNRIAALPIFAGIMILVYVLSVTTVGGILTDWVNDGVFGTDGWNLFGNPNLHVGSLPPLVDAGLDAINCAPWLHSLIVNGIIAGVGAVLGFVPQILVLFACLAFLESCGYMARVAFIMDRIFRKFGLSGKSFIPILIGTGCGVPGIMSSRTIENDRDRKMTIMTTTFIPCSAKLPIIALIAGAFFGNAWWVAPSAYFIGGAAIVCSGILLKKFRAFAGEPAPFVMELPSYHMPTAGTILRSMWERGFSFIKKAGTVILLATILIWALSSFGVVNGTWQMLDSVDMENSILAMIGHRIAIIFRPLGWGNWKFAVAAITGLMAKENVVGTFGILFGHMDSVAEDGTEVWAAVRTAVVPLAAYSYMVFNLLCAPCFAAMGAIRREMNNPKWFLAAIGYQCLLAYGAALCIYQIGMLTQGVFGVGTVVAFAIVALFIYLLVRPYKDVDDMGVSHLSIDAN
>NC_015737.1|WP_013977227.1|1388283_1388505_+|ferrous-iron-transport-protein-A
MKTLREAQVGETVTVKKVNGAGPVRRRIMDMGITKGIEVYIRKVAPLGDPVEVTIRGYELSIRKNDAEMILVG
>NC_015737.1|WP_013977226.1|1388024_1388234_+|ferrous-iron-transport-protein-A
MPLTMTNQGETCRIVRIGGNDKVRRHLENLGFAVGTEVTVVSRVSGSFIVNVKGSRVALGKELVSKIFI
>NC_015737.1|WP_083835061.1|1385593_1387546_+|cadmium-translocating-P-type-ATPase
MTKKQKRELKRILTAAGIFFALLILARISEASGWAELFFRNRWVMLGCYLVPFLIVGWPVVRGAAHGIANGQVFDEEFLMTLAAIGAFATGENAEAAAVMLFYQVGEFFQSYAVNKSRRSIRELMDIAPAEAVRERFDGTTEVIDPSQVEIGDILLIRPGEKVPVDGRVTEGSSLVDTAALTGEPVPRSVKPGDTIISGCINGDGLLRVCAEKKYADSTVARILELVENASARKSRTENFITRFARYYTPVVVLAAVVLAFVPPIFAGNLLQWIYRACTFLVISCPCALVISVPMAFFGGIGAASGMGILVKGSNFLEQMARLDTIVTDKTGTLTRGEFRVTRVIAAEGTEQEVLRTAAAAERGSTHPIAASICAACEAEEGEAAVSAVENISGKGIRAVIDGAEILVGSEKLLEERGIPVPAVDSGAATVAHVARNGRWMGTILISDTVKPEAAEAIRELKQEGVGKVVMLTGDRKETGEAVGRMLGLDHVYTELLPGDKVRQVEALLTQQNDRQTLAFVGDGTNDAPVLSRADIGIAMGVMGSDAAIEAADIVIMDDDLLRLPVVVRIARRTLFIAKQNIVFALAVKILILILGALGLANMWAAVFADVGVAIICILNAMRTLAKRRYRSRTEEKGQPVKEAAVSKTE
>NC_015737.1|WP_013977224.1|1385186_1385405_+|cation-transporter
MRKTYTMEDLDCANCAAKMEAAIKKIDGVREASVSFMTQKLIIEADEERFDEIMKQAQKAVSRVDRDCSILL
>NC_015737.1|WP_083834972.1|1384784_1385138_+|helix-turn-helix-transcriptional-regulator
MKLCSYEYGRRSAVNREEIHRIHEIDEAKLSDLAELFKMFGDTTRVKILYDLFSGEKSVSEITEDLDMNQSAISHQLKILKTAKLIRSRREGKAMIYSLADDHVKTIILMGKEHIEE
>NC_015737.1|WP_013977222.1|1383865_1384639_-|hypothetical-protein
MGLFNRNSDTKIERSDDDVIEAQRIQALAKNIYNDGKNTVLAYDEENLILEYKRRHDEFVLDGASTLLTYTCEDRMMGTREIGIWEKDLKDKRAGAHPAYKKSGSITFSKKDSDTFFHLYHDIKNCLTGKALFFTPETEFDEISFDSGDQILEFADGHRTYYIEYKDIIGADLNTNTKTITTTKTHVGKTRVSSSDNVGINGAEGKQDASSTTTIESYDLVIYLDDDQFLLMKKHYEANEGDDVQRMFQMLRDIIGE
>NC_015737.1|WP_013977221.1|1382129_1383773_+|Na/Pi-cotransporter-family-protein
MTLVDVFSLLGGVGLFLFGMTIMSSGLKNACGDNLQNILEKATKNKIIAVLVGLGMTMLIQSSSATDVMVIGFVNSAMMNLSQAIGVIMGANIGTTITAQITAFNIGAYAPVILFGGAVLYLFISRNLVKYIGEILMGFGMLFFGISVMKEAIIPLSKTQGFINFLTGLSNPFLAILFGVGFTALLQSSSSSTVIFQAFAIQGMLDYHTAVYLVIGAAIGSVTPNLLASLTTNRNGKRCAILNLLFNVIRAGILVALINCFPVLLDLIQGLSPNDVGRQIANTHTIFAIVAVLIELPFTEKIIRLSEKIIPIREEENEKLEDRKLQYMIGMGKMPVSMAVAQAHREVVRMGRIAARNLKDSMDCFFHYDTELAEKVRIREESVNILNHTIADAMVQLRTLDLTQINLRQVSNMTIAISDIERLSDHAENIVEYVEEMRRNKAELSDTAIAELRHMAEDAMHAVNLSLDIFETEDYGMLHQIESLENAVDHQEAELIHNHVERLMEEKCNPVAGVIFTDMVTALERCADHAINLAYALKERPADYEPA
>NC_015737.1|WP_013977220.1|1381174_1381624_+|Hsp20/alpha-crystallin-family-protein
MLFTPSIFRNTFADNVFDDFFNDQFWTPASGTPYNTMNTDIKETDGGYQIEMELPGFAKEDVSAQLKDGYLTVTATHSENKDEKDDKNEKYIRRERYSGHYQRSFYVGDEITDADVKASFKDGILTVAIPKKEPKKPEVEDAKYISIEG
>NC_015737.1|WP_013977230.1|1391392_1392544_+|ATPase
MLIKTIEEMEQDTREKLILDIRKPEDYARETYPGAQSMYWEMFDPETADLPKDRPIYLICYTGQKSEDLADELQEAGYEAYSIKQGYRAWISRKLHLSSGDPVLQQERCREIERSIQKKFRKEIWRKFTKAINTYDLIQDGDRIAVCISGGKDSMLMAKCFQELARHGKKNFETVFLVMNPGYNELNARTVEENARLLHVPITVFRSEIFDIVADQPDSPCYLCARMRRGHLYAKAKELGCNKIALGHHFDDVIETILMGMLYSGQIQTMMPKLHSTNFEGMELIRPMYLIREEDIRRWRDSNHLNFIACACRLTESCASCGGTEQGSKRAEIKALIADLHRQNPFVEKNIFRSVENVNLKTIIAYKKDGVRHSFLDEYEKES
>NC_015737.1|WP_013977233.1|1393468_1394131_+|signal-peptidase-I
MNSKKYSRGDAGREELQEIRQKTETPQHDASGQGLPSAASIKEEYTRVTEKRRFWGTIRSSVFVLIVVAAVAVLVAVMLLPILKIYGKSMHGTLDNGNIVISLKGAEFETGDIIAFYYNNNILVKRVIATSGEWVNIDKSGNVYVNQKKIDEPYLSSKAYGETNIDLPYQVPEGKVFVMGDNRKVSIDSRSTAIGCVSQEQIVGKIVFRIWPLSEMGTVG
>NC_015737.1|WP_013977234.1|1394215_1398814_+|VWA-domain-containing-protein
MKFMQKMIEKIMALRKTVKRRLRVIVALASVVVFATTYALILPGITLDQNTMTQQSGVTQEAGAGASGSDRKAESKEISKADTDGAAGEKKASESSESSKTAEHAAKTSDTKQKTAETDTAGQKKDTEQKKDTAQKEDSPQKQKDSKPDTEEDLITAETALTYQADDYTVTVSFDKAAQLPKGVKLKVHEITKDSAKKDYEAYQAGALKTLQNKDSRVSRLKSARFYDISFEKDGKTVEPSADVSVSIRYRDAIQTYSEKNIQAVHFKDNGKKEVVSLRTEGTSARASAKVKEVRFDADSFSVYGIVDTEKIASGVITADGTSATVEVSYKTDAGIPEGAELKVKEIRKDTKEYQNYLKQSEAALKKENGTGKKASEASEDTAEKKEENSQEDPKVSDAKFFDISILSDGKEIEPKAPVTVKITYADQVAVKTGQKMKAVHFASKGTEIIDIDKSAKGKDGGIASVTFRQDSFSVTGTVVQDLADGWPENGTYIMVLTNDNKNYYAVDSNGNLRNVNYDAGTGKVTFEQVTSEEQLSDYQWTVAGDQRGTYIRNGDGSAYIAPFASGGISKERAYLNRDQQGRLYSYSYYNGYNYLGMNTSTQTLKLKGQNRAEDSFTAKKIFFAESFRADKMDPAQPGEEEDSGGLNAPATEKTLSSNGDGTYNLSLSVTGASKATTSHTKADVIVVLDRSGSMRNSVSGSRRDVVAQNAINDLAKALLQNNTGAHPDTVQLSLVTFNNGAQTMVSGTSSLNTFQQAVNAAVGVYNTGTNWEAALKQADSVQTRSGAETYVIFVSDGNPTYYGTRPYGTGQETDQNILNSYNAARDDARSIVNKGKHFYTLGVFGDVSRMKNLTAYAYTGLESGYYPKDHYQTASNQSALNAAFANIIEDIQKNFTYTKVDITDGLTSMTASAVVSGSADSFTYKITDKDGNDITSTELTKIPGRASYNSSTHSVEWEMGDYDLKDGVTYTVSFTVWPSQAAYDLVADLNNGIKSYEGLTYAQKAQITKKADGTYGLNTNTTAQVKYQTVKRETNKDPVYSDPKTAGIANPDPVGLTASTLKLRKEWQDSSDSSQLLAILKENPDYKVILDLKKNSKAYKSGITITPTVSRDSDGNPVSAVWPEETIDIAPGLMVDKDSIDSYGLDTSKYTTVTYQGTVYYILEKGADYDITEQKEDYHFELDTETYHPMLVNGTLRNVVFTYGSSGSITGIKEIKDNPLTSLKASNRLKGSIALTKVVKDAAGNTIYPEKAEFTVHCVMEDKDGKAYTRDSQTVGSSESDGIVYRIVSRDGTKGKRIGVTDSSGFDVKLKAGETVEFLSLPTGTTWFFKETDIPNGYTQESFENIEGTVEANTQYTSTLTNRQTAAHVNILKVSATDNTKLGGATFELYKDSAHRTKATHPNGNEVGTIQTSSEGIGAIGALPIGDYYLVETKAPDGYDRLTSDVVIHVTADGVTYTQADNSASQDPLKPTVKDGVLTYTITIKNSTGVQLPAAGGSGTLPYTLGGCALSAAALMYGLLMRRRKKRVSDR
>NC_015737.1|WP_041727686.1|1398905_1400318_+|SpaH/EbpB-family-LPXTG-anchored-major-pilin
MKKGKTRKIIAFLLAAVMVLAMCIPAMAADNYTITVNNAKNGETYTAYKIFDASYASETDDAVSYTANKNIVNLIEGKPGAEGLTFKQIGTTDEYVVTVDKDTFNAAKAEEFAKLLDSVKDKLTAAAHVTAADGKAEITGLSKGYYFVDTTLGSLCALDTAKNVTVEEKNTIPSEEKTVSDTENGTYGSNANAQIGDTVYYQIQVTDSKGTDQAITVHDTMSKGLSLNTDSFTVTKDGETVPKDNYSVKTTGLTDVCTFEVTLNADYVKNLEENDVVVIKYSATLNENAVAGKDETNTSKLTYSNQTTTESTPKVHTYKFQVNKYDGADSNRNPLAGAKFKLLDKDGNLVKLVKANDAGTEYRVAKNENESGAVNEFVTVDSGNITITGVDADEGYSIEETEAPAGYNKLTGAVSITVNADNSLVQPVENNKGTALPSTGGRGTRIFYLVGIICVAGAGIVLVSRRRMSR
>NC_015737.1|WP_148267796.1|1400480_1401413_+|class-C-sortase
MNREKRRHGGRKGASRGTSAGRASRRGRQRVTLILLIIVFAVGVGLLLYPTVSNYWNSFHQSRAVMSYSAKVADMSKTDYSRILRNAKKYNRQITKHGINWNLSKKEKAAYERQLNVGEDGSMGYIDIPKISVQLPIYHGTNEAVLQTSIGHLEGTSLPIGGKGTHSVLSGHRGLPSAKLFTDLDQLREGDTFTIHVLNRTLTYEVDQIRIVEPTDLSDLKIVKGKDYCTLLTCTPYGINTHRLLVRGHRVKNLNGNASILADAIQIQPIYVIPFVAVPIIIVLVIYVFAVTGRRRRKHRGKTKSEGPEL
>NC_015737.1|WP_013977237.1|1401409_1402096_+|hypothetical-protein
MKMKVHVKLQTIGILAVLAAVLCFWLAAGSRPALADSGKTGTITVNVEDTDGHAVAGGTLAIYQVAAVQDGKFVYTRDFSSSTEKLEKNSDFSDQLADQLASIAEQSKAETMDTRTVDQKGTARFSNLPEGVYLFIQTKEADGYTTLNPFLVTVPFTDTDGVTTYDITANPKPGKVSKKTEPTPAPTPTPTPIDHRLPQTGQLWWPVPVLACAGAALLIAGSRKRKNA
>NC_015737.1|WP_083835062.1|1402253_1402907_+|sortase
MGQKKNETQNRPFRRLRILIRTAGIACILAAALLVLYNVWDSGRAGRESAAVAKQIQHTVTEEGLRKLDPNKEMPVVTIDGRQYIGTLEIPSISRRLPVMADWSYRNLKLAPCRYSGSYYADNLVICGHNYASHFSPLKWIAVGADVYFTNVEGLRLHYVVSNVETVRPTAVEEMVDNQAEKNSGGNSETGNKWDLTLFTCNTGGQTRCAVRCIRKN
>NC_015737.1|WP_148267797.1|1403054_1404224_-|C40-family-peptidase
MKSRFVRPMITAALSAALLIGSASAVSAAPAAADSGTGTAAASGSSAETSASSATASDRSASGAAGSSAAVSDGSSAAVSDGASETGNSAAAAAGSSSSAASGSAQSASGDSSEKNTESQTGSSSATTSKTPGAASGSASSRKSLSLRAPHITRVSSGRRVFTVRYGKVTGASGYEVRYSIHYDMSRSTRKDRKSSRSLTVRNLKSEGIYFVQVRAYGKTNGKKVYSKWSEKKAAKYVYYRSNLTEVRALSLLKNTKNSRSRNALQYALARAGHPYSQARRHSGIYYDCSSLAYYAYRSAGVKIASGRDFTAAGEAYRLRGKRVSYSSMKPGALIFFSYGRNGRYRNITHVAMYAGRGMLIEAANSRIGVVYRPIHSRGSIVMICDPAK
>NC_015737.1|WP_013977241.1|1404524_1405004_+|Cys-tRNA(Pro)-deacylase
MSKEAKTNAMRMLDRKKIPYEMLRYECEEFIDGMHMAEATGADADLSYKTLVMQGKSRQYYVYVIPIAMEVDLKKAARAVHEKSVEMIHVKDINKVTGYIRGGCSPIGMKKQYPTVIHCTAEQQPRIYISGGRIGLSLKLKPEDLVAMTGAVFADIARD
>NC_015737.1|WP_013977242.1|1405058_1405712_+|DUF308-domain-containing-protein
MKELFRKGLDAFRNYSIFLIVAGALMVVWPGTTVTVLFRILGVLLLITGFTGILEAFRSDDPTYRYVACVPAVVVILFGLWFLAAPGFVISIIPVLIGLALLFYGIRGLVFLGAVSGFRVTPVLFTSLASMVIGVVLIVHPWTMARILIVVLGILLILTGINGIYTSRKGRSMFDGFGKGSGKGPGSGSGPFGRKSRADRDVIDVDYQEEESHRIDR

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Crispr_ID: NC_015737_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015737_6

2161501-2165128

TypeI-E

Consensus_repeat	Method
GTAATTCCCGCGCGAGCGGGGGTGATCC	PILER-CR
GTAATTCCCGCGCGAGCGGGGGTGATCC	CRISPRCasFinder
GTAATTCCCGCGCGAGCGGGGGTGATCC	CRT

59 spacers

DEDDh,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,cas3

The CRISPR arrays of NC_015737_6

>merge|NC_015737|6|2161501-2165128|PILER-CR,CRISPRCasFinder,CRT
GTAATTCCCGCGCGAGCGGGGGTGATCCTGAGCGTAAAATTGGTTAAAGAGTCGGATTTGAGTAATTCCCGCGCGAGCGGGGGTGATCCCGCCGCAAGGCTGTCAATCTGCTTCTGCATTGCGTAATTCCCGCGCGAGCGGGGGTGATCCTACTGGCGTTTAGCCATGCGGGTAACAAGGTAAGTAATTCCCGCGCGAGCGGGGGTGATCCTCCGTTCCATGCCATCCCAGCTTGCTTGTGGACGTAATTCCCGCGCGAGCGGGGGTGATCCTATATATACCGTCCTTAAAAATCGCGTCTGTGGGTAATTCCCGCGCGAGCGGGGGTGATCCCAGCCTGTGCCATTCTAGCGATGCTATTCAGCCGTAATTCCCGCGCGAGCGGGGGTGATCCTAACCAACCCTTCGTCCAGACGCTCTTTAAACCGTAATTCCCGCGCGAGCGGGGGTGATCCTGGAACGTTATCCAATTGTATCGCCTCCTTTCTGTAATTCCCGCGCGAGCGGGGGTGATCCCTCTTCCATAATTTCGAAAATATCATATGGTTCGTAATTCCCGCGCGAGCGGGGGTGATCCTGAGTTACACCGGTATGACAATTCGGGAACTTGGTAATTCCCGCGCGAGCGGGGGTGATCCTTGAAAGAAAGGCAGGAGAAAAAAGATGACTGAGTAATTCCCGCGCGAGCGGGGGTGATCCTCTGCATGAATCCATCGCCCACAGGCTCACCAGGTAATTCCCGCGCGAGCGGGGGTGATCCTGCGCAATCACGTTTTTGTTTTCTTCCGGCAATGTAATTCCCGCGCGAGCGGGGGTGATCCCGAGCGGACCGCCGAAGGGAGAGAACTTAGTGAGTAATTCCCGCGCGAGCGGGGGTGATCCTTCCACCGTCAAGCACGCTGATCTTTACACGGAGTAATTCCCGCGCGAGCGGGGGTGATCCTGCGCCGCAGCAGCGTGGGACGAAAAGAACGGAGTAATTCCCGCGCGAGCGGGGGTGATCCTCCACCGCCCGCATATGCGTCGCATGGAATTTCGTAATTCCCGCGCGAGCGGGGGTGATCCTCTGATTCGCCCTTCCCCAATAAATTTATGAAGGTAATTCCCGCGCGAGCGGGGGTGATCCCGCATGGAGCCGATCGAAAAAAAGATACAAGATGTAATTCCCGCGCGAGCGGGGGTGATCCTAATTTTATACGGCCGTTCTGGCCGGGCGGAGAGTAATTCCCGCGCGAGCGGGGGTGATCCCGGTGGTATCACGTGGTTTGCCAGCAAAAAGTTGTAATTCCCGCGCGAGCGGGGGTGATCCCGGCGTTTTGCACAAATTTAGAGCCAGACACCTGTAATTCCCGCGCGAGCGGGGGTGATCCTGCGCAGCGGCAGCCTGGGACGAAAAGAACGGAGTAATTCCCGCGCGAGCGGGGGTGATCCTATGTTTTTTTGTCATCCATTTTTCACCTCCTGGTAATTCCCGCGCGAGCGGGGGTGATCCTACTGGCGTTGAGCCATGCGGGTAACAAGGTAAGTAATTCCCGCGCGAGCGGGGGTGATCCCAGCACCATCATCATCGCGACATCATAGCCGTTGTAATTCCCGCGCGAGCGGGGGTGATCCTCAGCGCAATTTTTGCATGGCTTCCGACAACGGGTAATTCCCGCGCGAGCGGGGGTGATCCTCATTTTTACACCGGAGCAGGTGTACCAGGTAAGTAATTCCCGCGCGAGCGGGGGTGATCCTATCGCATCCATGCCAGCGCTTCCGGTTCTGGCGTAATTCCCGCGCGAGCGGGGGTGATCCCATGTGTACAGCTATGTGTTATGTACAACTGTCGTAATTCCCGCGCGAGCGGGGGTGATCCCGATGTGGATGCCTTCGCGGAAGCGTATCTTGCGTAATTCCCGCGCGAGCGGGGGTGATCCTATTCTTTGCTTTTGACTTTTGACCGTCCAAAAGTAATTCCCGCGCGAGCGGGGGTGATCCCGGCGAACGGCTAAACAGCATCGCTAGAATGGCGTAATTCCCGCGCGAGCGGGGGTGATCCTCAAGTAATCAACGTGATTCTTTCCGTCAATTAGTAATTCCCGCGCGAGCGGGGGTGATCCTCAGGTAATCCACGTGATTCTTTCCATCAATGAGTAATTCCCGCGCGAGCGGGGGTGATCCTGCGCCGCAGCAGCGTGGGACGAAAAGAACGGAGTAATTCCCGCGCGAGCGGGGGTGATCCTGCGCCGCAGCAGCGTGGGACGAAAAGAACGGAGTAATTCCCGCGCGAGCGGGGGTGATCCTGACAGCGACAAGGAAGACCTGAAGCGCGCGAAGTAATTCCCGCGCGAGCGGGGGTGATCCCATGGGATTGGCCATGGAAGGCGGCAGATCAGGGTAATTCCCGCGCGAGCGGGGGTGATCCCGGCGGACGAGGATTGCACGGTGATTGCTTAATGTAATTCCCGCGCGAGCGGGGGTGATCCCCAGCCATACACAGCGGCAATTTTTCCCGGCAAGTAATTCCCGCGCGAGCGGGGGTGATCCCAACAATCTGTGTGTAAGGACTAATCAACTCAAGTAATTCCCGCGCGAGCGGGGGTGATCCCACGGTTGACGTTCTGGCCAGAAGATCAATGTTGTAATTCCCGCGCGAGCGGGGGTGATCCCAACGGAAGTTGGACAGGATAAATGCATGTGGGGTAATTCCCGCGCGAGCGGGGGTGATCCCGAGCGATCCGCCGAAGGAAGGGGACTCAGCGAGTAATTCCCGCGCGAGCGGGGGTGATCCTGCTCGGAAGGTCATATCCTCTGCTTTGACGAGGTAATTCCCGCGCGAGCGGGGGTGATCCCAGGCGAACACCGGGAAAGGGCTGCAGTGGTTGGTAATTCCCGCGCGAGCGGGGGTGATCCTCACGGCATTTTTTAAAGCCCGTGAAAGCACCAGTAATTCCCGCGCGAGCGGGGGTGATCCCGCCGCGCCGCCGCAATTCTCTGCGCACGGAAGGTAATTCCCGCGCGAGCGGGGGTGATCCTGCTGAGAAAGGCAAACAAAAAAATGTCGTTGGGTAATTCCCGCGCGAGCGGGGGTGATCCCCCTCGCAAGCAGGCCCCACGCAAGTCGGCTCCGTAATTCCCGCGCGAGCGGGGGTGATCCTACGGCGATCCTGACGGCCTGGGCGATCTGCAGGTAATTCCCGCGCGAGCGGGGGTGATCCTCCGACAAGAGGCCGGCCATCAGCAACCATGTAGTAATTCCCGCGCGAGCGGGGGTGATCCTGGATTGACTACGCAAAGCCCTGCGATAATGGGGTAATTCCCGCGCGAGCGGGGGTGATCCTACCATTAGTCAAGATTCCGAACTTTGCTTTTGGTAATTCCCGCGCGAGCGGGGGTGATCCTAATTGCACTATCTTTGATATTTTGTAAATTCAGTAATTCCCGCGCGAGCGGGGGTGATCCCTTTGTCCCCTGTGCCTTTGGCGCATAATTCCCGTAATTCCCGCGCGAGCGGGGGTGATCCTGCCATATTATGATCTGATTCTTTGATCCCAAAGTAATTCCCGCGCGAGCGGGGGTGATCCTCACCCCGGATGTAAAGCACGTCACTTTTTATGGTAATTCCCGCGCGAGCGGGGGTGATCCT

>NC_015737|6|3|2161501-2165127|PILER-CR
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGAGCGTAAAATTGGTTAAAGAGTCGGATTTGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCCGCAAGGCTGTCAATCTGCTTCTGCATTGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACTGGCGTTTAGCCATGCGGGTAACAAGGTAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCCGTTCCATGCCATCCCAGCTTGCTTGTGGAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATATATACCGTCCTTAAAAATCGCGTCTGTGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGCCTGTGCCATTCTAGCGATGCTATTCAGCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TAACCAACCCTTCGTCCAGACGCTCTTTAAACC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGGAACGTTATCCAATTGTATCGCCTCCTTTCT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CTCTTCCATAATTTCGAAAATATCATATGGTTC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGAGTTACACCGGTATGACAATTCGGGAACTTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TTGAAAGAAAGGCAGGAGAAAAAAGATGACTGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCTGCATGAATCCATCGCCCACAGGCTCACCAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCAATCACGTTTTTGTTTTCTTCCGGCAAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGAGCGGACCGCCGAAGGGAGAGAACTTAGTGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TTCCACCGTCAAGCACGCTGATCTTTACACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCCGCAGCAGCGTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCCACCGCCCGCATATGCGTCGCATGGAATTTC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCTGATTCGCCCTTCCCCAATAAATTTATGAAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCATGGAGCCGATCGAAAAAAAGATACAAGAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TAATTTTATACGGCCGTTCTGGCCGGGCGGAGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGTGGTATCACGTGGTTTGCCAGCAAAAAGTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCGTTTTGCACAAATTTAGAGCCAGACACCT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCAGCGGCAGCCTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATGTTTTTTTGTCATCCATTTTTCACCTCCTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACTGGCGTTGAGCCATGCGGGTAACAAGGTAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGCACCATCATCATCGCGACATCATAGCCGTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAGCGCAATTTTTGCATGGCTTCCGACAACGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCATTTTTACACCGGAGCAGGTGTACCAGGTAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATCGCATCCATGCCAGCGCTTCCGGTTCTGGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATGTGTACAGCTATGTGTTATGTACAACTGTC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGATGTGGATGCCTTCGCGGAAGCGTATCTTGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATTCTTTGCTTTTGACTTTTGACCGTCCAAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCGAACGGCTAAACAGCATCGCTAGAATGGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAAGTAATCAACGTGATTCTTTCCGTCAATTA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAGGTAATCCACGTGATTCTTTCCATCAATGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCCGCAGCAGCGTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCCGCAGCAGCGTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGACAGCGACAAGGAAGACCTGAAGCGCGCGAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATGGGATTGGCCATGGAAGGCGGCAGATCAGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCGGACGAGGATTGCACGGTGATTGCTTAAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCAGCCATACACAGCGGCAATTTTTCCCGGCAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAACAATCTGTGTGTAAGGACTAATCAACTCAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CACGGTTGACGTTCTGGCCAGAAGATCAATGTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAACGGAAGTTGGACAGGATAAATGCATGTGGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGAGCGATCCGCCGAAGGAAGGGGACTCAGCGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCTCGGAAGGTCATATCCTCTGCTTTGACGAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGGCGAACACCGGGAAAGGGCTGCAGTGGTTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCACGGCATTTTTTAAAGCCCGTGAAAGCACCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCCGCGCCGCCGCAATTCTCTGCGCACGGAAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCTGAGAAAGGCAAACAAAAAAATGTCGTTGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCCTCGCAAGCAGGCCCCACGCAAGTCGGCTCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACGGCGATCCTGACGGCCTGGGCGATCTGCAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCCGACAAGAGGCCGGCCATCAGCAACCATGTA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGGATTGACTACGCAAAGCCCTGCGATAATGGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACCATTAGTCAAGATTCCGAACTTTGCTTTTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TAATTGCACTATCTTTGATATTTTGTAAATTCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CTTTGTCCCCTGTGCCTTTGGCGCATAATTCCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCCATATTATGATCTGATTCTTTGATCCCAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCACCCCGGATGTAAAGCACGTCACTTTTTATG
GTAATTCCCGCGCGAGCGGGGGTGATCC

>NC_015737|6|4|2161501-2165128|CRISPRCasFinder
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGAGCGTAAAATTGGTTAAAGAGTCGGATTTGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCCGCAAGGCTGTCAATCTGCTTCTGCATTGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACTGGCGTTTAGCCATGCGGGTAACAAGGTAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCCGTTCCATGCCATCCCAGCTTGCTTGTGGAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATATATACCGTCCTTAAAAATCGCGTCTGTGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGCCTGTGCCATTCTAGCGATGCTATTCAGCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TAACCAACCCTTCGTCCAGACGCTCTTTAAACC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGGAACGTTATCCAATTGTATCGCCTCCTTTCT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CTCTTCCATAATTTCGAAAATATCATATGGTTC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGAGTTACACCGGTATGACAATTCGGGAACTTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TTGAAAGAAAGGCAGGAGAAAAAAGATGACTGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCTGCATGAATCCATCGCCCACAGGCTCACCAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCAATCACGTTTTTGTTTTCTTCCGGCAAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGAGCGGACCGCCGAAGGGAGAGAACTTAGTGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TTCCACCGTCAAGCACGCTGATCTTTACACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCCGCAGCAGCGTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCCACCGCCCGCATATGCGTCGCATGGAATTTC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCTGATTCGCCCTTCCCCAATAAATTTATGAAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCATGGAGCCGATCGAAAAAAAGATACAAGAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TAATTTTATACGGCCGTTCTGGCCGGGCGGAGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGTGGTATCACGTGGTTTGCCAGCAAAAAGTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCGTTTTGCACAAATTTAGAGCCAGACACCT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCAGCGGCAGCCTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATGTTTTTTTGTCATCCATTTTTCACCTCCTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACTGGCGTTGAGCCATGCGGGTAACAAGGTAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGCACCATCATCATCGCGACATCATAGCCGTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAGCGCAATTTTTGCATGGCTTCCGACAACGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCATTTTTACACCGGAGCAGGTGTACCAGGTAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATCGCATCCATGCCAGCGCTTCCGGTTCTGGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATGTGTACAGCTATGTGTTATGTACAACTGTC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGATGTGGATGCCTTCGCGGAAGCGTATCTTGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATTCTTTGCTTTTGACTTTTGACCGTCCAAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCGAACGGCTAAACAGCATCGCTAGAATGGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAAGTAATCAACGTGATTCTTTCCGTCAATTA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAGGTAATCCACGTGATTCTTTCCATCAATGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCCGCAGCAGCGTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCCGCAGCAGCGTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGACAGCGACAAGGAAGACCTGAAGCGCGCGAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATGGGATTGGCCATGGAAGGCGGCAGATCAGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCGGACGAGGATTGCACGGTGATTGCTTAAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCAGCCATACACAGCGGCAATTTTTCCCGGCAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAACAATCTGTGTGTAAGGACTAATCAACTCAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CACGGTTGACGTTCTGGCCAGAAGATCAATGTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAACGGAAGTTGGACAGGATAAATGCATGTGGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGAGCGATCCGCCGAAGGAAGGGGACTCAGCGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCTCGGAAGGTCATATCCTCTGCTTTGACGAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGGCGAACACCGGGAAAGGGCTGCAGTGGTTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCACGGCATTTTTTAAAGCCCGTGAAAGCACCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCCGCGCCGCCGCAATTCTCTGCGCACGGAAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCTGAGAAAGGCAAACAAAAAAATGTCGTTGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCCTCGCAAGCAGGCCCCACGCAAGTCGGCTCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACGGCGATCCTGACGGCCTGGGCGATCTGCAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCCGACAAGAGGCCGGCCATCAGCAACCATGTA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGGATTGACTACGCAAAGCCCTGCGATAATGGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACCATTAGTCAAGATTCCGAACTTTGCTTTTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TAATTGCACTATCTTTGATATTTTGTAAATTCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CTTTGTCCCCTGTGCCTTTGGCGCATAATTCCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCCATATTATGATCTGATTCTTTGATCCCAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCACCCCGGATGTAAAGCACGTCACTTTTTATG
GTAATTCCCGCGCGAGCGGGGGTGATCCT

>NC_015737|6|1|2161501-2165127|CRT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGAGCGTAAAATTGGTTAAAGAGTCGGATTTGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCCGCAAGGCTGTCAATCTGCTTCTGCATTGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACTGGCGTTTAGCCATGCGGGTAACAAGGTAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCCGTTCCATGCCATCCCAGCTTGCTTGTGGAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATATATACCGTCCTTAAAAATCGCGTCTGTGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGCCTGTGCCATTCTAGCGATGCTATTCAGCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TAACCAACCCTTCGTCCAGACGCTCTTTAAACC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGGAACGTTATCCAATTGTATCGCCTCCTTTCT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CTCTTCCATAATTTCGAAAATATCATATGGTTC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGAGTTACACCGGTATGACAATTCGGGAACTTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TTGAAAGAAAGGCAGGAGAAAAAAGATGACTGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCTGCATGAATCCATCGCCCACAGGCTCACCAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCAATCACGTTTTTGTTTTCTTCCGGCAAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGAGCGGACCGCCGAAGGGAGAGAACTTAGTGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TTCCACCGTCAAGCACGCTGATCTTTACACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCCGCAGCAGCGTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCCACCGCCCGCATATGCGTCGCATGGAATTTC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCTGATTCGCCCTTCCCCAATAAATTTATGAAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCATGGAGCCGATCGAAAAAAAGATACAAGAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TAATTTTATACGGCCGTTCTGGCCGGGCGGAGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGTGGTATCACGTGGTTTGCCAGCAAAAAGTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCGTTTTGCACAAATTTAGAGCCAGACACCT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCAGCGGCAGCCTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATGTTTTTTTGTCATCCATTTTTCACCTCCTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACTGGCGTTGAGCCATGCGGGTAACAAGGTAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGCACCATCATCATCGCGACATCATAGCCGTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAGCGCAATTTTTGCATGGCTTCCGACAACGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCATTTTTACACCGGAGCAGGTGTACCAGGTAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATCGCATCCATGCCAGCGCTTCCGGTTCTGGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATGTGTACAGCTATGTGTTATGTACAACTGTC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGATGTGGATGCCTTCGCGGAAGCGTATCTTGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATTCTTTGCTTTTGACTTTTGACCGTCCAAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCGAACGGCTAAACAGCATCGCTAGAATGGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAAGTAATCAACGTGATTCTTTCCGTCAATTA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAGGTAATCCACGTGATTCTTTCCATCAATGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCCGCAGCAGCGTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCGCCGCAGCAGCGTGGGACGAAAAGAACGGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGACAGCGACAAGGAAGACCTGAAGCGCGCGAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATGGGATTGGCCATGGAAGGCGGCAGATCAGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCGGACGAGGATTGCACGGTGATTGCTTAAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCAGCCATACACAGCGGCAATTTTTCCCGGCAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAACAATCTGTGTGTAAGGACTAATCAACTCAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CACGGTTGACGTTCTGGCCAGAAGATCAATGTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAACGGAAGTTGGACAGGATAAATGCATGTGGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGAGCGATCCGCCGAAGGAAGGGGACTCAGCGA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCTCGGAAGGTCATATCCTCTGCTTTGACGAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGGCGAACACCGGGAAAGGGCTGCAGTGGTTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCACGGCATTTTTTAAAGCCCGTGAAAGCACCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCCGCGCCGCCGCAATTCTCTGCGCACGGAAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCTGAGAAAGGCAAACAAAAAAATGTCGTTGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCCTCGCAAGCAGGCCCCACGCAAGTCGGCTCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACGGCGATCCTGACGGCCTGGGCGATCTGCAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCCGACAAGAGGCCGGCCATCAGCAACCATGTA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGGATTGACTACGCAAAGCCCTGCGATAATGGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACCATTAGTCAAGATTCCGAACTTTGCTTTTG
GTAATTCCCGCGCGAGCGGGGGTGATCC	TAATTGCACTATCTTTGATATTTTGTAAATTCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CTTTGTCCCCTGTGCCTTTGGCGCATAATTCCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCCATATTATGATCTGATTCTTTGATCCCAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCACCCCGGATGTAAAGCACGTCACTTTTTATG
GTAATTCCCGCGCGAGCGGGGGTGATCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015737.1\|WP_148267817.1\|2158167_2158896_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|187886
NC_015737.1\|WP_013977921.1\|2156468_2157050_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	mkCas0194_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NC_015737.1\|WP_050979269.1\|2159576_2160482_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_015737.1\|WP_158309840.1\|2154714_2156472_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|378189
NC_015737.1\|WP_013977933.1\|2170425_2170758_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977924.1\|2158897_2159530_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl\|CDD\|378050
NC_015737.1\|WP_148267870.1\|2151980_2154731_+\|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
NC_015737.1\|WP_158309839.1\|2149552_2150509_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_015737.1\|WP_013977935.1\|2171390_2171600_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977922.1\|2157099_2158161_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_015737.1\|WP_013977790.1\|2166108_2166396_-\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_015737.1\|WP_013977938.1\|2172436_2172727_-\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977790.1\|2168254_2168542_-\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_015737.1\|WP_158309841.1\|2173337_2173508_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977926.1\|2160488_2161424_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
NC_015737.1\|WP_041727858.1\|2165203_2166112_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_015737.1\|WP_041727861.1\|2170824_2171280_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_148267871.1\|2172040_2172301_+\|preprotein-translocase-subunit-SecA	unknown	unknown	unknown
NC_015737.1\|WP_013977918.1\|2150688_2151231_-\|glutathione-peroxidase	unknown	unknown	gnl\|CDD\|223463
NC_015737.1\|WP_013977939.1\|2172723_2172987_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015737.1\|WP_148267817.1\|2158167_2158896_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|187886	cd09756, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	4.58918e-47
NC_015737.1\|WP_013977921.1\|2156468_2157050_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	5.5545e-38
NC_015737.1\|WP_050979269.1\|2159576_2160482_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	6.98921e-132
NC_015737.1\|WP_158309840.1\|2154714_2156472_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	2.39782e-90
NC_015737.1\|WP_013977924.1\|2158897_2159530_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	2.09125e-75
NC_015737.1\|WP_148267870.1\|2151980_2154731_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	8.13591e-82
NC_015737.1\|WP_158309839.1\|2149552_2150509_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	8.89675e-12
NC_015737.1\|WP_013977922.1\|2157099_2158161_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	4.25813e-151
NC_015737.1\|WP_013977790.1\|2166108_2166396_-\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	3.16009e-05
NC_015737.1\|WP_013977790.1\|2168254_2168542_-\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	3.16009e-05
NC_015737.1\|WP_013977926.1\|2160488_2161424_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	1.65445e-48
NC_015737.1\|WP_041727858.1\|2165203_2166112_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	2.11342e-68
NC_015737.1\|WP_013977918.1\|2150688_2151231_-\|glutathione-peroxidase	gnl\|CDD\|223463	COG0386, BtuE, Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones].	1.42598e-80

>NC_015737.1|WP_013977926.1|2160488_2161424_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MPFTVIVLKKVPNSLRGDLTRWMQEIATGVYVGSYNSKVREYLWKRVTDTVGQGEASMCYACRNEIGYSFCTCNTDRQVVDYDGIPLVLIPAKDTEEENIAGISMGFSNANKFRHACQMRKISGTTKLSPELNTGCSGVNNSNNQDIVFLDIETTGLDAESDQIIEIGAIKISKNRQTEFHRLINSEMHIPDIVQKLTGITEEMLKTGSTLEDSIRDFDRFIQSAVLIGYNVSFDIKFLNRAFERMSLNTIHNKTLDLLREAKRENCFQDNYKFETTLKEYGIDQSVFHRALEDAKLVQLLYNKMGFVKKL
>NC_015737.1|WP_050979269.1|2159576_2160482_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MPRISDRVTYIYVEHSKINRVDGSITVAESRGIVRIPASMIGILLLGPGTDISHRAMELLGDSGTSVAWVGEQGVRNYAHGRSLSHTSRFLELQAKLVSNTRSRLQVARKMYQMRFPEEDVSSLTMQQLRAKEGARIRKIYRKMSAEYGVDWNGRTYDPDDFEGGDPVNQALSAANVALYGLAYSAIAAMGLATGLGFVHTGHDLSFVYDIADLYKADITVPVAFEIASEYEEGDNVGKISRQKVRDKFIGGKLFATIVRDIQLLFGIKEEEQLNVEPLSLWDNREGNIKYGINYSNENED
>NC_015737.1|WP_013977924.1|2158897_2159530_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSRVEIDVRNRRKIKDLTHLGAYHNWVECSFPNEWKESIRSRKLWRIDTLQGRRYLLLVSEEKPDLEKLEKYGIHGSAQTKSYDKFLTSITEGGIYRFRVTLNPVKSISRGEGKRGRVVPEITATQQLRYLEERADQLGFELIPDEYQIVERGWEAFRKQGQEMIRLSKATYEGLLKITNRDVFYHTLTRGVGKKKAYGFGLMTVIPV
>NC_015737.1|WP_148267817.1|2158167_2158896_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MIVLKTVLLKFAGPLQSWGTDSHFETRHTDTHPSKSGVLGMIAAGLGYGRDDDENLSKLNALQFAVRVDQAGQILRDYHTAKKYKKNGELERTYVTNRYYLQDAVFLVALSSDEESLVNDVKTAVTYPYYPIFLGRRALPPTAELFQGIYNTDAVTLLKEYPWQASVRYQQRHSNRIQIYADSVLLDSNSIRLRNDIACSFSQIQGRKFRLRKEARITVDAVIPDKPDKKDEHDIFKALGED
>NC_015737.1|WP_013977922.1|2157099_2158161_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MAENRFYLDMHVIQTLPPSNVNRDDTGSPKTAVYGGVRRARVSSQAWKRAMRKYFLNESEEDLGVRSLDVVKYVSDRIRAADPSVNEENAMDMSEKLFNVAGIKTKDQKTKALFFLGKKQAEELAAAAIQGETDKKTVQEIFRSNPAVDIALFGRMVADDPSLNEDASAQVAHAISTHGVQTEFDFYTAVDDLAPEDNAGAGMLGTIEYNSSTLYRYANIAMHELSKQLADKEQTIHAAKLFVEAFANSMPTGKANTFANQTLPQLLMINIRQDRPVNLVSAFENPISSKNGIVVPSINRLFDEVKKTEKFVSVPVKSFYVVDEDVNKPEWAVEEDTLSDLLNDFAEAAGMLL
>NC_015737.1|WP_013977921.1|2156468_2157050_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MNTESNKPSVYDTMAGILAHMNGPQEKKNIAGHLAAIRNSIGKGYENTAEVWPIIFPLMPAEYLGNGAMTYEEKALLVTLQLYAIGQQGSNKTQGDRSRNFGSSLRNIRGIESAALDRRFNTMLTATTFEEFAYHLRQIFKLAKSKNTFSVNFPALAEDLFWYQKDKDKMVCLRWAREYYRPSLKKDTVSSDE
>NC_015737.1|WP_158309840.1|2154714_2156472_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MMGRFNLLDEPWISVLDGKTGEKRDVSLLEFFQNGGKYQTLAGDTETQNFAVMRFLLSIIQTVFSRFDFEGAVLPGVELDERWVQTESVDEDDLDEYCDAVSECWDRLYLNGSFPDVVSQYLEKWRDRFFLFDEVHPFYQVNQQEMNDIMELIPQKSQPTTIYGKNLNRTISESENKIALFSPIVQTGSGKRSKKDIMTSAQLVRWLITFQGYSGLADKVSLVNTVEKQRPSKGWLFDLGGVFLQGSNVFETLVMNYIPEFPANRKQLCGRIQNPCWEADGSLVVKRIYSGKQIDNLAELYTNWSRSIYIDPMMDMADPVEINIVKLPEIEHTENSIEPMTLWRWNENGPNKNHFTPKKHNAEQALWRSFGIIAMNPSSGESSRQFRPGIYGQYRRLAKVAGSRWTNLTGVSMADDGNATSWLPVDEISDSFMINDLVIADEEPDGWIVRINDVVETTKEVVSTIFKSYLRGICEIRDLKVTSPMDPNAAGFIEREIAEMYALIDSSFKEWICSIEPGDSKEEKIKSWNTQLRRQVLNRGEELYESSMMRDLTGIEKDNKIVNIATKYWQFVYRVNNKLGKGGAA
>NC_015737.1|WP_148267870.1|2151980_2154731_+|CRISPR-associated-helicase-Cas3'
MCTPLWAKKEERAGRFYWLSLVTHLEDTMNVSRWLWNNWLSDRQREFCINSINPSNEETASDLAAFLGAVHDIGKATPAFQTQKGFSNSPDLDVMLLEKLERAGFSGIADLTLTGSRKSHHTVAGEYLLSQFQVKDDIGSIIGGHHGKPADERFEIEDQSAYVENLFQNEDKTSEIYKKWSHVQKGIFNWALEAASFENADQLPEISKPGQVIYSGLLIMADWIASNAEYFPLIPIDSEYNTDCTARYKNGISAWYKNLPLQIQSYPQADELFNYRFGFQPRNFQKIVCETVGHIHEPGIVILEAPMGLGKTEAALAAAEEIASKTGSSGLFFGLPTQATSNSMFERVHQWLENLTDAYDEKQSLRLQHGKAALNEEMNRLQNASSVDLDGESGSNVYVNQWFSGRKKASLDDFVVGTVDGFLLTALKQKHLALRHLGFSKKVIIIDEVHAYDTYMQQYLEEALRWMGAYGAPVILVSATLPLEKRKELISAYLKGKGVKGRDIVFPEILTGCHYPLISYTDGMTVKAQASFEPVKDKIVYIKKISEDGLLDKVTELLKGNGVIGIIVNTVSKAQKLGKICKEHFGNDTVDILHSAIIATDRVRKENTLMRMIGKGGDRPKRKIIIGTQVIEQSLDIDFDVLITDLCPVDLLIQRIGRLHRHEIQRPERHREPVVYVMGTSTQLEFEKGTERIYAKYYLIRTQYFLPGEIRIPTDIPILIDQVYGGKKIELQGEQGKIYQASSKQMELDKQNKQNKALTYRIDAPHIRIKPDKYNLIGWLENPDFSRSDETAAAQVRDIADTIEVIAVKQTGNGYGTFDNEEDISARIDEPGISRELTKQTIRLPLFATRKKGISATIEFLEKYNLKCLPDWQDQPWLKGSLGIIFDENGRFGMNGIILKYDNEYGLREEKNDGKV
>NC_015737.1|WP_013977918.1|2150688_2151231_-|glutathione-peroxidase
MAFYDYKVMDRNGEELSLKEYEGKVVLVVNTATGCGFTPQYKDLETMYEAFHDRGLEILDIPCNQFAGQTPGTDEEIHEFCTLKYNTQFPQMKKSEVNGPNALPLYTYLKSQQGFKGFGKGPKAVMMGAMLHKIDKDYKNNPEIKWNFTKFLVDRNGAVVARFEPTESMEKVSAAVEKLL
>NC_015737.1|WP_158309839.1|2149552_2150509_+|CPBP-family-intramembrane-metalloprotease
MKDRTYFSIAGFGMLGYSMASLWIYRLVTLLAYRWNPQLASSQYFTWFVYYGLLFGVGGLICFRILRHLPKKKIFRHRMRPSDIFQALCISLFLMYVGSGIGQWLNRLLSASSESTVSSRFSDLIEQSDLRIVILIVVLIGPIAEELIFRKLLIDRMIVFGDRTAILLSAFLFAIYHGTFTQCFYAFFLGLVFAYVYIRTGRPFVNIGLHMLINGIGTLGPILLSRILHQSISNITAGSLRSIGNPMALIGVGTYSMVLLVLAAAGIVFLILRLHRGLEIRLGERSMPAGPTARVMFLNAGMLGWVAWCTYLFVRSLS
>NC_015737.1|WP_041727858.1|2165203_2166112_-|IS3-family-transposase
MTEAIYLGVSKKTEAARKQGRRVSVSGMLKYLGVSRSGYRSWLNRTPSDTEKRREYIKRKIQDIYEESKQNYGAPKITKKLRQRGEIISERTVGKCMREMGIKAQWVKPWTITTIDSDLSYELKNLLDEQFSPDRPNAVWCSDITYIWTVDGFVYLTSIMDLFSRKIIAWTLSKTLEVSCVIDTINKAKAKRNTELPLIIHSDRGSQYVSKAYRDATVKMQRSYSKKAFPWDNACIEAFHALIKREWLNRFKIRDYQQAYRLVFEYIEAFYNTKRIHSHCDYMSPDDFEKLYEQTDELLLVS
>NC_015737.1|WP_013977790.1|2166108_2166396_-|transposase
MMARQHDKQFKLDAVQYYFEHKELGVRGCAQNLGVGYSTLTRWLREFRESGDITVRGSGNYASDEQKEIARLKRELRDAKDALDVLKKAISILGK
>NC_015737.1|WP_013977790.1|2168254_2168542_-|transposase
MMARQHDKQFKLDAVQYYFEHKELGVRGCAQNLGVGYSTLTRWLREFRESGDITVRGSGNYASDEQKEIARLKRELRDAKDALDVLKKAISILGK
>NC_015737.1|WP_013977933.1|2170425_2170758_+|hypothetical-protein
MKQEEDRLSDDFTEYVQKLTEKVLKSPSLKRVTVGSSHELFQYFSEDLANVTKDIAGHFYSAGSQADIMPDATLITAKGKLDGERAIIIIRTDHKPAPFSSAAKDDVRIV
>NC_015737.1|WP_041727861.1|2170824_2171280_+|hypothetical-protein
MFIIEKKYTVDGKSEAILNSSWIHGDASMTDRQKENAVKRIIRKVQKETQDEMYIPKLKSVLSQNAVTESPVNVKEVIEDVIGQEADQYMKAEGVGEKDEMQNYSDSSKVTVTTDTGIRITAEADDVLKGKDIRIDDGKIIISGFSEYKIS
>NC_015737.1|WP_013977935.1|2171390_2171600_+|hypothetical-protein
MKKNFKEYMEGYDAALKLHHEAFHAYCMEMREAAPTAVKEALQTNYRTLLLAIRKQELDDLRKEQKGRG
>NC_015737.1|WP_148267871.1|2172040_2172301_+|preprotein-translocase-subunit-SecA
MVACASLIDELEQITLDEAADIVFVQDSTPAVENYHNYHGRRTAIIRCHRPEEKTYQYSAEETARRLHMTDMTFVKASGKTVEIQY
>NC_015737.1|WP_013977938.1|2172436_2172727_-|hypothetical-protein
MIGDHLLHGSNGKELGYLVEHLSWSKCDWGITEDLPKGVSGRLYDRNNRHDWRKGPIACTRIEGIITRNVKFWEDMVFYGHSRRKPFFVKTAYGVK
>NC_015737.1|WP_013977939.1|2172723_2172987_-|hypothetical-protein
METKRALNTQTLREEAFEPNIHDAIVDFKAGMDAQFIEHVEEKHLGVSNKYLRERITKGEWDDDLKKSFSLVNRRQSTASLHLSCVE
>NC_015737.1|WP_158309841.1|2173337_2173508_+|hypothetical-protein
MAAIIGVLIWLICLILVIYLTHKKNRSMVGMVIFAVFLPVIALIVILCMKPIPRVE

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Crispr_ID: NC_015737_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015737_7

2166503-2167263

TypeI-E

Consensus_repeat	Method
GTAATTCCCGCGCGAGCGGGGGTGATCC	PILER-CR
GTAATTCCCGCGCGAGCGGGGGTGATCC	CRISPRCasFinder
GTAATTCCCGCGCGAGCGGGGGTGATCC	CRT

12 spacers

DEDDh,cas1,cas6e,cas5,cas7,cse2gr11,cas8e,cas3

The CRISPR arrays of NC_015737_7

>merge|NC_015737|7|2166503-2167263|PILER-CR,CRISPRCasFinder,CRT
GTAATTCCCGCGCGAGCGGGGGTGATCCCATACCGGTTTGTATGGGATCCGTGCCGCCCGGGTAATTCCCGCGCGAGCGGGGGTGATCCCTTTGTCCTTTGCACTGATCCCGTCAGCGCTATGTAATTCCCGCGCGAGCGGGGGTGATCCTGATTCCGGCATCAAGGCCACCTCGTCAAAAAAGTAATTCCCGCGCGAGCGGGGGTGATCCCACGGGACGGGCTCCCATATTGATAGTGCCAACGTAATTCCCGCGCGAGCGGGGGTGATCCTATAAGACGGTGATTTCACTTTAATTCTATGAAGTAATTCCCGCGCGAGCGGGGGTGATCCTCTTAAAATCCGGATCCTGCGCGTACCGGTAAGGTAATTCCCGCGCGAGCGGGGGTGATCCCGCTGGCCGAAGCGTTCATAGATAAACATGAACGTAATTCCCGCGCGAGCGGGGGTGATCCCAGGAGGCTGACCAGATTGCCGACATTCTTAGCGTAATTCCCGCGCGAGCGGGGGTGATCCTGAAAGAAACTCACCCAAAGCAGTACGATTATAGTAATTCCCGCGCGAGCGGGGGTGATCCCAGGAAAAACTCAACCGGCTAAAATACATATACGTAATTCCCGCGCGAGCGGGGGTGATCCCGCCCGGATATCATCCGGGCAAGCTTGAAAAGTGTAATTCCCGCGCGAGCGGGGGTGATCCCATAAAGGAGATGCTTGACGATGGCAAAGAAGGGTAATTCCCGCGCGAGCGGGGGTGATCCT

>NC_015737|7|4|2166503-2167262|PILER-CR
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATACCGGTTTGTATGGGATCCGTGCCGCCCGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CTTTGTCCTTTGCACTGATCCCGTCAGCGCTAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGATTCCGGCATCAAGGCCACCTCGTCAAAAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CACGGGACGGGCTCCCATATTGATAGTGCCAAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATAAGACGGTGATTTCACTTTAATTCTATGAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCTTAAAATCCGGATCCTGCGCGTACCGGTAAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCTGGCCGAAGCGTTCATAGATAAACATGAAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGGAGGCTGACCAGATTGCCGACATTCTTAGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGAAAGAAACTCACCCAAAGCAGTACGATTATA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGGAAAAACTCAACCGGCTAAAATACATATAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCCCGGATATCATCCGGGCAAGCTTGAAAAGT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATAAAGGAGATGCTTGACGATGGCAAAGAAGG
GTAATTCCCGCGCGAGCGGGGGTGATCC

>NC_015737|7|5|2166503-2167263|CRISPRCasFinder
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATACCGGTTTGTATGGGATCCGTGCCGCCCGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CTTTGTCCTTTGCACTGATCCCGTCAGCGCTAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGATTCCGGCATCAAGGCCACCTCGTCAAAAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CACGGGACGGGCTCCCATATTGATAGTGCCAAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATAAGACGGTGATTTCACTTTAATTCTATGAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCTTAAAATCCGGATCCTGCGCGTACCGGTAAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCTGGCCGAAGCGTTCATAGATAAACATGAAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGGAGGCTGACCAGATTGCCGACATTCTTAGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGAAAGAAACTCACCCAAAGCAGTACGATTATA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGGAAAAACTCAACCGGCTAAAATACATATAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCCCGGATATCATCCGGGCAAGCTTGAAAAGT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATAAAGGAGATGCTTGACGATGGCAAAGAAGG
GTAATTCCCGCGCGAGCGGGGGTGATCCT

>NC_015737|7|2|2166503-2167262|CRT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATACCGGTTTGTATGGGATCCGTGCCGCCCGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CTTTGTCCTTTGCACTGATCCCGTCAGCGCTAT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGATTCCGGCATCAAGGCCACCTCGTCAAAAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CACGGGACGGGCTCCCATATTGATAGTGCCAAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TATAAGACGGTGATTTCACTTTAATTCTATGAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCTTAAAATCCGGATCCTGCGCGTACCGGTAAG
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCTGGCCGAAGCGTTCATAGATAAACATGAAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGGAGGCTGACCAGATTGCCGACATTCTTAGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGAAAGAAACTCACCCAAAGCAGTACGATTATA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CAGGAAAAACTCAACCGGCTAAAATACATATAC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGCCCGGATATCATCCGGGCAAGCTTGAAAAGT
GTAATTCCCGCGCGAGCGGGGGTGATCC	CATAAAGGAGATGCTTGACGATGGCAAAGAAGG
GTAATTCCCGCGCGAGCGGGGGTGATCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015737.1\|WP_013977943.1\|2174794_2175616_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375542
NC_015737.1\|WP_148267817.1\|2158167_2158896_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|187886
NC_015737.1\|WP_013977921.1\|2156468_2157050_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	mkCas0194_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NC_015737.1\|WP_050979269.1\|2159576_2160482_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_015737.1\|WP_158309840.1\|2154714_2156472_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|378189
NC_015737.1\|WP_013977933.1\|2170425_2170758_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_148267870.1\|2151980_2154731_+\|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
NC_015737.1\|WP_013977924.1\|2158897_2159530_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl\|CDD\|378050
NC_015737.1\|WP_013977935.1\|2171390_2171600_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977922.1\|2157099_2158161_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_015737.1\|WP_013977790.1\|2166108_2166396_-\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_015737.1\|WP_013977938.1\|2172436_2172727_-\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977790.1\|2168254_2168542_-\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_015737.1\|WP_013977941.1\|2173629_2174499_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|214792
NC_015737.1\|WP_013977926.1\|2160488_2161424_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
NC_015737.1\|WP_041727858.1\|2165203_2166112_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_015737.1\|WP_041727861.1\|2170824_2171280_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_148267871.1\|2172040_2172301_+\|preprotein-translocase-subunit-SecA	unknown	unknown	unknown
NC_015737.1\|WP_158309841.1\|2173337_2173508_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977939.1\|2172723_2172987_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015737.1\|WP_148267817.1\|2158167_2158896_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|187886	cd09756, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	4.58918e-47
NC_015737.1\|WP_013977921.1\|2156468_2157050_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	5.5545e-38
NC_015737.1\|WP_050979269.1\|2159576_2160482_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	6.98921e-132
NC_015737.1\|WP_158309840.1\|2154714_2156472_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	2.39782e-90
NC_015737.1\|WP_148267870.1\|2151980_2154731_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	8.13591e-82
NC_015737.1\|WP_013977924.1\|2158897_2159530_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	2.09125e-75
NC_015737.1\|WP_013977922.1\|2157099_2158161_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	4.25813e-151
NC_015737.1\|WP_013977790.1\|2166108_2166396_-\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	3.16009e-05
NC_015737.1\|WP_013977790.1\|2168254_2168542_-\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	3.16009e-05
NC_015737.1\|WP_013977926.1\|2160488_2161424_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	1.65445e-48
NC_015737.1\|WP_041727858.1\|2165203_2166112_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	2.11342e-68
NC_015737.1\|WP_013977941.1\|2173629_2174499_-\|radical-SAM-protein	gnl\|CDD\|214792	smart00729, Elp3, Elongator protein 3, MiaB family, Radical SAM. This superfamily contains MoaA, NifB, PqqE, coproporphyrinogen III oxidase, biotin synthase and MiaB families, and includes a representative in the eukaryotic elongator subunit, Elp-3. Some members of the family are methyltransferases.	2.90429e-28
NC_015737.1\|WP_013977943.1\|2174794_2175616_-\|hypothetical-protein	gnl\|CDD\|375542	pfam18089, DAPG_hydrolase, DAPG hydrolase PhiG domain. This domain is found in 2,4-diacetylphloroglucinol hydrolase PhiG present in Pseudomonas fluorescens. 2,4-diacetylphloroglucinol hydrolase is the gene product of PhiG that is responsible for cleaving toxic 2,4-diacetylphloroglucinol (DAPG). The small N-terminal region of the domain is involved in dimerization through hydrogen bonding of the dimer interface. The C-terminal catalytic region resembles the tetracenomycin aromatase/cyclase and has a Bet v1-like fold. DAPG PhiG is the first discovered hydrolase whose catalytic domain belongs to the Bet v1-like fold, rather than the classical alpha/beta-fold hydrolases.	2.37158e-95

>NC_015737.1|WP_013977790.1|2166108_2166396_-|transposase
MMARQHDKQFKLDAVQYYFEHKELGVRGCAQNLGVGYSTLTRWLREFRESGDITVRGSGNYASDEQKEIARLKRELRDAKDALDVLKKAISILGK
>NC_015737.1|WP_041727858.1|2165203_2166112_-|IS3-family-transposase
MTEAIYLGVSKKTEAARKQGRRVSVSGMLKYLGVSRSGYRSWLNRTPSDTEKRREYIKRKIQDIYEESKQNYGAPKITKKLRQRGEIISERTVGKCMREMGIKAQWVKPWTITTIDSDLSYELKNLLDEQFSPDRPNAVWCSDITYIWTVDGFVYLTSIMDLFSRKIIAWTLSKTLEVSCVIDTINKAKAKRNTELPLIIHSDRGSQYVSKAYRDATVKMQRSYSKKAFPWDNACIEAFHALIKREWLNRFKIRDYQQAYRLVFEYIEAFYNTKRIHSHCDYMSPDDFEKLYEQTDELLLVS
>NC_015737.1|WP_013977926.1|2160488_2161424_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MPFTVIVLKKVPNSLRGDLTRWMQEIATGVYVGSYNSKVREYLWKRVTDTVGQGEASMCYACRNEIGYSFCTCNTDRQVVDYDGIPLVLIPAKDTEEENIAGISMGFSNANKFRHACQMRKISGTTKLSPELNTGCSGVNNSNNQDIVFLDIETTGLDAESDQIIEIGAIKISKNRQTEFHRLINSEMHIPDIVQKLTGITEEMLKTGSTLEDSIRDFDRFIQSAVLIGYNVSFDIKFLNRAFERMSLNTIHNKTLDLLREAKRENCFQDNYKFETTLKEYGIDQSVFHRALEDAKLVQLLYNKMGFVKKL
>NC_015737.1|WP_050979269.1|2159576_2160482_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MPRISDRVTYIYVEHSKINRVDGSITVAESRGIVRIPASMIGILLLGPGTDISHRAMELLGDSGTSVAWVGEQGVRNYAHGRSLSHTSRFLELQAKLVSNTRSRLQVARKMYQMRFPEEDVSSLTMQQLRAKEGARIRKIYRKMSAEYGVDWNGRTYDPDDFEGGDPVNQALSAANVALYGLAYSAIAAMGLATGLGFVHTGHDLSFVYDIADLYKADITVPVAFEIASEYEEGDNVGKISRQKVRDKFIGGKLFATIVRDIQLLFGIKEEEQLNVEPLSLWDNREGNIKYGINYSNENED
>NC_015737.1|WP_013977924.1|2158897_2159530_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSRVEIDVRNRRKIKDLTHLGAYHNWVECSFPNEWKESIRSRKLWRIDTLQGRRYLLLVSEEKPDLEKLEKYGIHGSAQTKSYDKFLTSITEGGIYRFRVTLNPVKSISRGEGKRGRVVPEITATQQLRYLEERADQLGFELIPDEYQIVERGWEAFRKQGQEMIRLSKATYEGLLKITNRDVFYHTLTRGVGKKKAYGFGLMTVIPV
>NC_015737.1|WP_148267817.1|2158167_2158896_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MIVLKTVLLKFAGPLQSWGTDSHFETRHTDTHPSKSGVLGMIAAGLGYGRDDDENLSKLNALQFAVRVDQAGQILRDYHTAKKYKKNGELERTYVTNRYYLQDAVFLVALSSDEESLVNDVKTAVTYPYYPIFLGRRALPPTAELFQGIYNTDAVTLLKEYPWQASVRYQQRHSNRIQIYADSVLLDSNSIRLRNDIACSFSQIQGRKFRLRKEARITVDAVIPDKPDKKDEHDIFKALGED
>NC_015737.1|WP_013977922.1|2157099_2158161_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MAENRFYLDMHVIQTLPPSNVNRDDTGSPKTAVYGGVRRARVSSQAWKRAMRKYFLNESEEDLGVRSLDVVKYVSDRIRAADPSVNEENAMDMSEKLFNVAGIKTKDQKTKALFFLGKKQAEELAAAAIQGETDKKTVQEIFRSNPAVDIALFGRMVADDPSLNEDASAQVAHAISTHGVQTEFDFYTAVDDLAPEDNAGAGMLGTIEYNSSTLYRYANIAMHELSKQLADKEQTIHAAKLFVEAFANSMPTGKANTFANQTLPQLLMINIRQDRPVNLVSAFENPISSKNGIVVPSINRLFDEVKKTEKFVSVPVKSFYVVDEDVNKPEWAVEEDTLSDLLNDFAEAAGMLL
>NC_015737.1|WP_013977921.1|2156468_2157050_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MNTESNKPSVYDTMAGILAHMNGPQEKKNIAGHLAAIRNSIGKGYENTAEVWPIIFPLMPAEYLGNGAMTYEEKALLVTLQLYAIGQQGSNKTQGDRSRNFGSSLRNIRGIESAALDRRFNTMLTATTFEEFAYHLRQIFKLAKSKNTFSVNFPALAEDLFWYQKDKDKMVCLRWAREYYRPSLKKDTVSSDE
>NC_015737.1|WP_158309840.1|2154714_2156472_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MMGRFNLLDEPWISVLDGKTGEKRDVSLLEFFQNGGKYQTLAGDTETQNFAVMRFLLSIIQTVFSRFDFEGAVLPGVELDERWVQTESVDEDDLDEYCDAVSECWDRLYLNGSFPDVVSQYLEKWRDRFFLFDEVHPFYQVNQQEMNDIMELIPQKSQPTTIYGKNLNRTISESENKIALFSPIVQTGSGKRSKKDIMTSAQLVRWLITFQGYSGLADKVSLVNTVEKQRPSKGWLFDLGGVFLQGSNVFETLVMNYIPEFPANRKQLCGRIQNPCWEADGSLVVKRIYSGKQIDNLAELYTNWSRSIYIDPMMDMADPVEINIVKLPEIEHTENSIEPMTLWRWNENGPNKNHFTPKKHNAEQALWRSFGIIAMNPSSGESSRQFRPGIYGQYRRLAKVAGSRWTNLTGVSMADDGNATSWLPVDEISDSFMINDLVIADEEPDGWIVRINDVVETTKEVVSTIFKSYLRGICEIRDLKVTSPMDPNAAGFIEREIAEMYALIDSSFKEWICSIEPGDSKEEKIKSWNTQLRRQVLNRGEELYESSMMRDLTGIEKDNKIVNIATKYWQFVYRVNNKLGKGGAA
>NC_015737.1|WP_148267870.1|2151980_2154731_+|CRISPR-associated-helicase-Cas3'
MCTPLWAKKEERAGRFYWLSLVTHLEDTMNVSRWLWNNWLSDRQREFCINSINPSNEETASDLAAFLGAVHDIGKATPAFQTQKGFSNSPDLDVMLLEKLERAGFSGIADLTLTGSRKSHHTVAGEYLLSQFQVKDDIGSIIGGHHGKPADERFEIEDQSAYVENLFQNEDKTSEIYKKWSHVQKGIFNWALEAASFENADQLPEISKPGQVIYSGLLIMADWIASNAEYFPLIPIDSEYNTDCTARYKNGISAWYKNLPLQIQSYPQADELFNYRFGFQPRNFQKIVCETVGHIHEPGIVILEAPMGLGKTEAALAAAEEIASKTGSSGLFFGLPTQATSNSMFERVHQWLENLTDAYDEKQSLRLQHGKAALNEEMNRLQNASSVDLDGESGSNVYVNQWFSGRKKASLDDFVVGTVDGFLLTALKQKHLALRHLGFSKKVIIIDEVHAYDTYMQQYLEEALRWMGAYGAPVILVSATLPLEKRKELISAYLKGKGVKGRDIVFPEILTGCHYPLISYTDGMTVKAQASFEPVKDKIVYIKKISEDGLLDKVTELLKGNGVIGIIVNTVSKAQKLGKICKEHFGNDTVDILHSAIIATDRVRKENTLMRMIGKGGDRPKRKIIIGTQVIEQSLDIDFDVLITDLCPVDLLIQRIGRLHRHEIQRPERHREPVVYVMGTSTQLEFEKGTERIYAKYYLIRTQYFLPGEIRIPTDIPILIDQVYGGKKIELQGEQGKIYQASSKQMELDKQNKQNKALTYRIDAPHIRIKPDKYNLIGWLENPDFSRSDETAAAQVRDIADTIEVIAVKQTGNGYGTFDNEEDISARIDEPGISRELTKQTIRLPLFATRKKGISATIEFLEKYNLKCLPDWQDQPWLKGSLGIIFDENGRFGMNGIILKYDNEYGLREEKNDGKV
>NC_015737.1|WP_013977790.1|2168254_2168542_-|transposase
MMARQHDKQFKLDAVQYYFEHKELGVRGCAQNLGVGYSTLTRWLREFRESGDITVRGSGNYASDEQKEIARLKRELRDAKDALDVLKKAISILGK
>NC_015737.1|WP_013977933.1|2170425_2170758_+|hypothetical-protein
MKQEEDRLSDDFTEYVQKLTEKVLKSPSLKRVTVGSSHELFQYFSEDLANVTKDIAGHFYSAGSQADIMPDATLITAKGKLDGERAIIIIRTDHKPAPFSSAAKDDVRIV
>NC_015737.1|WP_041727861.1|2170824_2171280_+|hypothetical-protein
MFIIEKKYTVDGKSEAILNSSWIHGDASMTDRQKENAVKRIIRKVQKETQDEMYIPKLKSVLSQNAVTESPVNVKEVIEDVIGQEADQYMKAEGVGEKDEMQNYSDSSKVTVTTDTGIRITAEADDVLKGKDIRIDDGKIIISGFSEYKIS
>NC_015737.1|WP_013977935.1|2171390_2171600_+|hypothetical-protein
MKKNFKEYMEGYDAALKLHHEAFHAYCMEMREAAPTAVKEALQTNYRTLLLAIRKQELDDLRKEQKGRG
>NC_015737.1|WP_148267871.1|2172040_2172301_+|preprotein-translocase-subunit-SecA
MVACASLIDELEQITLDEAADIVFVQDSTPAVENYHNYHGRRTAIIRCHRPEEKTYQYSAEETARRLHMTDMTFVKASGKTVEIQY
>NC_015737.1|WP_013977938.1|2172436_2172727_-|hypothetical-protein
MIGDHLLHGSNGKELGYLVEHLSWSKCDWGITEDLPKGVSGRLYDRNNRHDWRKGPIACTRIEGIITRNVKFWEDMVFYGHSRRKPFFVKTAYGVK
>NC_015737.1|WP_013977939.1|2172723_2172987_-|hypothetical-protein
METKRALNTQTLREEAFEPNIHDAIVDFKAGMDAQFIEHVEEKHLGVSNKYLRERITKGEWDDDLKKSFSLVNRRQSTASLHLSCVE
>NC_015737.1|WP_158309841.1|2173337_2173508_+|hypothetical-protein
MAAIIGVLIWLICLILVIYLTHKKNRSMVGMVIFAVFLPVIALIVILCMKPIPRVE
>NC_015737.1|WP_013977941.1|2173629_2174499_-|radical-SAM-protein
MNYEGIVYRPPSEARSLILQVTIGCAHNQCTFCTMYKAKNFRIRTLEEIRKDIHETAAAYGDIFRRIFLADGDALILPTETLLEILKELKQHFPSAERITSYGTPADVLRKTPDELKQLRSAGLAMVYMGAESGDDTVLSRIHKGVSSDEILAAGLRLRQSGIAVSVTLISGLGGRARIEEHAVASARLISGIRPEYVGFLTLMLDPAAPIRQELASGQMELLKPEELVDEMELFLRKVDAPGTVFRSNHASNYMMLKGTLNDDIPAMLARLADIRAHKGYRKESWRAL
>NC_015737.1|WP_013977943.1|2174794_2175616_-|hypothetical-protein
MSKVPCTNADKQKSYYKFYAADGYWGEQEKYSQITKEPLDPATAPRIEDRNDLFLPGYLPGEFGWWKLENGTAVIANKTFFPNTTGEMFDWWFAWHPIDRLRYACWNNEDHYDVYLEDPARALDMTKSMRERHWGSVHHIWEDIGLPGGAGMLIIAFKRPSELGYDESKIDTDACSTLVCAKTTIVGDDQTPDLDVVMTHFLRPAEGGSELRSRFWFGYTIDDNGKAVKTIPDGFTVPDAGPYCLLNHNVKEFSNLAKILPDLYAEEKDHWAV

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Crispr_ID: NC_015737_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_015737_8

2168638-2169702

TypeI-E

Consensus_repeat	Method
GTAATTCCCGCGCGAGCGGGGGTGATCC	CRISPRCasFinder
GTAATTCCCGCGCGAGCGGGGGTGATCC	CRT
GTAATTCCCGCGCGAGCGGGGGTGATCC	PILER-CR

17 spacers

DEDDh,cas1,cas6e,cas5,cas7,cse2gr11,cas8e

The CRISPR arrays of NC_015737_8

>merge|NC_015737|8|2168638-2169702|CRISPRCasFinder,CRT,PILER-CR
GTAATTCCCGCGCGAGCGGGGGTGATCCTACTTCATCATTGCATTTGCAACGTTATCTGAAGTAATTCCCGCGCGAGCGGGGGTGATCCTGTAATTAGATGTGTAGACACTGACGGAATAGCGTAATTCCCGCGCGAGCGGGGGTGATCCCGGCTACAAGTTCAACCAAAATAGCGGTTTCGGGTAATTCCCGCGCGAGCGGGGGTGATCCGCTGAAACACTTAAATGCCCTGTTTGTGGCTCAGTAATTCCCGCGCGAGCGGGGGTGATCCCGTGGTGTAACTTTGCCCTGATATACATTCATAGTAATTCCCGCGCGAGCGGGGGTGATCCCCAGTGGAACGGTCCCGCCGGGTTACAATTAAAGTAATTCCCGCGCGAGCGGGGGTGATCCTGCTGGCGGTGATCCGGACACCGAGAACGGCGCGTAATTCCCGCGCGAGCGGGGGTGATTTTGCTGTATGCTTCACTGCCAAACCTGCCAGAGCGTAATTCCCGCGCGAGCGGGGGTGATCCCGGTCATAGCAGTCCGGACAGATGAACGGATGCGTAATTCCCGCGCGAGCGGGGGTGATCCCCGCCACGCTCCGACAGGCTCCGCGCCCATGCCGTAATTCCCGCGCGAGCGGGGGTGATCCTGTGCTGCGCCGCATGATTTCCTTTTTCGGCTTGTAATTCCCGCGCGAGCGGGGGTGATCCTTATATCAGATACCGGTTGTCGCTACGATAGCAGTAATTCCCGCGCGAGCGGGGGTGATCCCCAGTCAGAGCGGAATGCAAGCGAAATAAAAACGTAATTCCCGCGTGAGCGGGGGTGATCCCGGGAAAACGTTGATCGTTTCAGGCAGATCGGCGTAATTCCCGCGCGAGCGGGGGTGATCCTCAAAATAAAAAGCCCCTACGTCCTTCAGCGCAGTAATTCCCGCGTGAGCGGGGGTGATCCCACTTTTAACGGGTTTTGTTAAATCCAATTTCGGTAATTCCCGCGTGAGCGGGGGTGATCCCATCGCAGTTCCTCCTAAAACGTTTCTTCGCTTGTAATTCCCGCATGAGCGGGGGTGATCC

>NC_015737|8|6|2168638-2169702|CRISPRCasFinder
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACTTCATCATTGCATTTGCAACGTTATCTGAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGTAATTAGATGTGTAGACACTGACGGAATAGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCTACAAGTTCAACCAAAATAGCGGTTTCGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	GCTGAAACACTTAAATGCCCTGTTTGTGGCTCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGTGGTGTAACTTTGCCCTGATATACATTCATA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCAGTGGAACGGTCCCGCCGGGTTACAATTAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCTGGCGGTGATCCGGACACCGAGAACGGCGC
GTAATTCCCGCGCGAGCGGGGGTGATTT	TGCTGTATGCTTCACTGCCAAACCTGCCAGAGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGTCATAGCAGTCCGGACAGATGAACGGATGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCGCCACGCTCCGACAGGCTCCGCGCCCATGCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGTGCTGCGCCGCATGATTTCCTTTTTCGGCTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TTATATCAGATACCGGTTGTCGCTACGATAGCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCAGTCAGAGCGGAATGCAAGCGAAATAAAAAC
GTAATTCCCGCGTGAGCGGGGGTGATCC	CGGGAAAACGTTGATCGTTTCAGGCAGATCGGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAAAATAAAAAGCCCCTACGTCCTTCAGCGCA
GTAATTCCCGCGTGAGCGGGGGTGATCC	CACTTTTAACGGGTTTTGTTAAATCCAATTTCG
GTAATTCCCGCGTGAGCGGGGGTGATCC	CATCGCAGTTCCTCCTAAAACGTTTCTTCGCTT
GTAATTCCCGCATGAGCGGGGGTGATCC

>NC_015737|8|3|2168638-2169702|CRT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TACTTCATCATTGCATTTGCAACGTTATCTGAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGTAATTAGATGTGTAGACACTGACGGAATAGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCTACAAGTTCAACCAAAATAGCGGTTTCGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	GCTGAAACACTTAAATGCCCTGTTTGTGGCTCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGTGGTGTAACTTTGCCCTGATATACATTCATA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCAGTGGAACGGTCCCGCCGGGTTACAATTAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCTGGCGGTGATCCGGACACCGAGAACGGCGC
GTAATTCCCGCGCGAGCGGGGGTGATTT	TGCTGTATGCTTCACTGCCAAACCTGCCAGAGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGTCATAGCAGTCCGGACAGATGAACGGATGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCGCCACGCTCCGACAGGCTCCGCGCCCATGCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGTGCTGCGCCGCATGATTTCCTTTTTCGGCTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TTATATCAGATACCGGTTGTCGCTACGATAGCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCAGTCAGAGCGGAATGCAAGCGAAATAAAAAC
GTAATTCCCGCGTGAGCGGGGGTGATCC	CGGGAAAACGTTGATCGTTTCAGGCAGATCGGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAAAATAAAAAGCCCCTACGTCCTTCAGCGCA
GTAATTCCCGCGTGAGCGGGGGTGATCC	CACTTTTAACGGGTTTTGTTAAATCCAATTTCG
GTAATTCCCGCGTGAGCGGGGGTGATCC	CATCGCAGTTCCTCCTAAAACGTTTCTTCGCTT
GTAATTCCCGCATGAGCGGGGGTGATCC

>NC_015737|8|5|2168760-2169702|PILER-CR
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGCTACAAGTTCAACCAAAATAGCGGTTTCGG
GTAATTCCCGCGCGAGCGGGGGTGATCC	GCTGAAACACTTAAATGCCCTGTTTGTGGCTCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGTGGTGTAACTTTGCCCTGATATACATTCATA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCAGTGGAACGGTCCCGCCGGGTTACAATTAAA
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGCTGGCGGTGATCCGGACACCGAGAACGGCGC
GTAATTCCCGCGCGAGCGGGGGTGATTT	TGCTGTATGCTTCACTGCCAAACCTGCCAGAGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CGGTCATAGCAGTCCGGACAGATGAACGGATGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCGCCACGCTCCGACAGGCTCCGCGCCCATGCC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TGTGCTGCGCCGCATGATTTCCTTTTTCGGCTT
GTAATTCCCGCGCGAGCGGGGGTGATCC	TTATATCAGATACCGGTTGTCGCTACGATAGCA
GTAATTCCCGCGCGAGCGGGGGTGATCC	CCAGTCAGAGCGGAATGCAAGCGAAATAAAAAC
GTAATTCCCGCGTGAGCGGGGGTGATCC	CGGGAAAACGTTGATCGTTTCAGGCAGATCGGC
GTAATTCCCGCGCGAGCGGGGGTGATCC	TCAAAATAAAAAGCCCCTACGTCCTTCAGCGCA
GTAATTCCCGCGTGAGCGGGGGTGATCC	CACTTTTAACGGGTTTTGTTAAATCCAATTTCG
GTAATTCCCGCGTGAGCGGGGGTGATCC	CATCGCAGTTCCTCCTAAAACGTTTCTTCGCTT
GTAATTCCCGCATGAGCGGGGGTGATCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_015737.1\|WP_013977943.1\|2174794_2175616_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375542
NC_015737.1\|WP_148267817.1\|2158167_2158896_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|187886
NC_015737.1\|WP_013977921.1\|2156468_2157050_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	mkCas0194_cse2gr11_CAS-I-E	gnl\|CDD\|378191
NC_015737.1\|WP_050979269.1\|2159576_2160482_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
NC_015737.1\|WP_158309840.1\|2154714_2156472_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|378189
NC_015737.1\|WP_013977933.1\|2170425_2170758_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977944.1\|2175798_2176749_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_015737.1\|WP_041727861.1\|2170824_2171280_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977924.1\|2158897_2159530_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl\|CDD\|378050
NC_015737.1\|WP_013977935.1\|2171390_2171600_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977922.1\|2157099_2158161_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
NC_015737.1\|WP_013977790.1\|2166108_2166396_-\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_015737.1\|WP_013977938.1\|2172436_2172727_-\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977790.1\|2168254_2168542_-\|transposase	unknown	unknown	gnl\|CDD\|366690
NC_015737.1\|WP_013977926.1\|2160488_2161424_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
NC_015737.1\|WP_041727858.1\|2165203_2166112_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_015737.1\|WP_013977941.1\|2173629_2174499_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|214792
NC_015737.1\|WP_148267871.1\|2172040_2172301_+\|preprotein-translocase-subunit-SecA	unknown	unknown	unknown
NC_015737.1\|WP_158309841.1\|2173337_2173508_+\|hypothetical-protein	unknown	unknown	unknown
NC_015737.1\|WP_013977939.1\|2172723_2172987_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_015737.1\|WP_148267817.1\|2158167_2158896_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|187886	cd09756, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	4.58918e-47
NC_015737.1\|WP_013977921.1\|2156468_2157050_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	5.5545e-38
NC_015737.1\|WP_050979269.1\|2159576_2160482_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	6.98921e-132
NC_015737.1\|WP_158309840.1\|2154714_2156472_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	2.39782e-90
NC_015737.1\|WP_013977943.1\|2174794_2175616_-\|hypothetical-protein	gnl\|CDD\|375542	pfam18089, DAPG_hydrolase, DAPG hydrolase PhiG domain. This domain is found in 2,4-diacetylphloroglucinol hydrolase PhiG present in Pseudomonas fluorescens. 2,4-diacetylphloroglucinol hydrolase is the gene product of PhiG that is responsible for cleaving toxic 2,4-diacetylphloroglucinol (DAPG). The small N-terminal region of the domain is involved in dimerization through hydrogen bonding of the dimer interface. The C-terminal catalytic region resembles the tetracenomycin aromatase/cyclase and has a Bet v1-like fold. DAPG PhiG is the first discovered hydrolase whose catalytic domain belongs to the Bet v1-like fold, rather than the classical alpha/beta-fold hydrolases.	2.37158e-95
NC_015737.1\|WP_013977924.1\|2158897_2159530_+\|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl\|CDD\|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	2.09125e-75
NC_015737.1\|WP_013977922.1\|2157099_2158161_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	4.25813e-151
NC_015737.1\|WP_013977790.1\|2166108_2166396_-\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	3.16009e-05
NC_015737.1\|WP_013977790.1\|2168254_2168542_-\|transposase	gnl\|CDD\|366690	pfam01527, HTH_Tnp_1, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	3.16009e-05
NC_015737.1\|WP_013977926.1\|2160488_2161424_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	1.65445e-48
NC_015737.1\|WP_041727858.1\|2165203_2166112_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	2.11342e-68
NC_015737.1\|WP_013977941.1\|2173629_2174499_-\|radical-SAM-protein	gnl\|CDD\|214792	smart00729, Elp3, Elongator protein 3, MiaB family, Radical SAM. This superfamily contains MoaA, NifB, PqqE, coproporphyrinogen III oxidase, biotin synthase and MiaB families, and includes a representative in the eukaryotic elongator subunit, Elp-3. Some members of the family are methyltransferases.	2.90429e-28
NC_015737.1\|WP_013977944.1\|2175798_2176749_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.88389e-31

>NC_015737.1|WP_013977790.1|2168254_2168542_-|transposase
MMARQHDKQFKLDAVQYYFEHKELGVRGCAQNLGVGYSTLTRWLREFRESGDITVRGSGNYASDEQKEIARLKRELRDAKDALDVLKKAISILGK
>NC_015737.1|WP_013977790.1|2166108_2166396_-|transposase
MMARQHDKQFKLDAVQYYFEHKELGVRGCAQNLGVGYSTLTRWLREFRESGDITVRGSGNYASDEQKEIARLKRELRDAKDALDVLKKAISILGK
>NC_015737.1|WP_041727858.1|2165203_2166112_-|IS3-family-transposase
MTEAIYLGVSKKTEAARKQGRRVSVSGMLKYLGVSRSGYRSWLNRTPSDTEKRREYIKRKIQDIYEESKQNYGAPKITKKLRQRGEIISERTVGKCMREMGIKAQWVKPWTITTIDSDLSYELKNLLDEQFSPDRPNAVWCSDITYIWTVDGFVYLTSIMDLFSRKIIAWTLSKTLEVSCVIDTINKAKAKRNTELPLIIHSDRGSQYVSKAYRDATVKMQRSYSKKAFPWDNACIEAFHALIKREWLNRFKIRDYQQAYRLVFEYIEAFYNTKRIHSHCDYMSPDDFEKLYEQTDELLLVS
>NC_015737.1|WP_013977926.1|2160488_2161424_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MPFTVIVLKKVPNSLRGDLTRWMQEIATGVYVGSYNSKVREYLWKRVTDTVGQGEASMCYACRNEIGYSFCTCNTDRQVVDYDGIPLVLIPAKDTEEENIAGISMGFSNANKFRHACQMRKISGTTKLSPELNTGCSGVNNSNNQDIVFLDIETTGLDAESDQIIEIGAIKISKNRQTEFHRLINSEMHIPDIVQKLTGITEEMLKTGSTLEDSIRDFDRFIQSAVLIGYNVSFDIKFLNRAFERMSLNTIHNKTLDLLREAKRENCFQDNYKFETTLKEYGIDQSVFHRALEDAKLVQLLYNKMGFVKKL
>NC_015737.1|WP_050979269.1|2159576_2160482_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MPRISDRVTYIYVEHSKINRVDGSITVAESRGIVRIPASMIGILLLGPGTDISHRAMELLGDSGTSVAWVGEQGVRNYAHGRSLSHTSRFLELQAKLVSNTRSRLQVARKMYQMRFPEEDVSSLTMQQLRAKEGARIRKIYRKMSAEYGVDWNGRTYDPDDFEGGDPVNQALSAANVALYGLAYSAIAAMGLATGLGFVHTGHDLSFVYDIADLYKADITVPVAFEIASEYEEGDNVGKISRQKVRDKFIGGKLFATIVRDIQLLFGIKEEEQLNVEPLSLWDNREGNIKYGINYSNENED
>NC_015737.1|WP_013977924.1|2158897_2159530_+|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MYLSRVEIDVRNRRKIKDLTHLGAYHNWVECSFPNEWKESIRSRKLWRIDTLQGRRYLLLVSEEKPDLEKLEKYGIHGSAQTKSYDKFLTSITEGGIYRFRVTLNPVKSISRGEGKRGRVVPEITATQQLRYLEERADQLGFELIPDEYQIVERGWEAFRKQGQEMIRLSKATYEGLLKITNRDVFYHTLTRGVGKKKAYGFGLMTVIPV
>NC_015737.1|WP_148267817.1|2158167_2158896_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MIVLKTVLLKFAGPLQSWGTDSHFETRHTDTHPSKSGVLGMIAAGLGYGRDDDENLSKLNALQFAVRVDQAGQILRDYHTAKKYKKNGELERTYVTNRYYLQDAVFLVALSSDEESLVNDVKTAVTYPYYPIFLGRRALPPTAELFQGIYNTDAVTLLKEYPWQASVRYQQRHSNRIQIYADSVLLDSNSIRLRNDIACSFSQIQGRKFRLRKEARITVDAVIPDKPDKKDEHDIFKALGED
>NC_015737.1|WP_013977922.1|2157099_2158161_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MAENRFYLDMHVIQTLPPSNVNRDDTGSPKTAVYGGVRRARVSSQAWKRAMRKYFLNESEEDLGVRSLDVVKYVSDRIRAADPSVNEENAMDMSEKLFNVAGIKTKDQKTKALFFLGKKQAEELAAAAIQGETDKKTVQEIFRSNPAVDIALFGRMVADDPSLNEDASAQVAHAISTHGVQTEFDFYTAVDDLAPEDNAGAGMLGTIEYNSSTLYRYANIAMHELSKQLADKEQTIHAAKLFVEAFANSMPTGKANTFANQTLPQLLMINIRQDRPVNLVSAFENPISSKNGIVVPSINRLFDEVKKTEKFVSVPVKSFYVVDEDVNKPEWAVEEDTLSDLLNDFAEAAGMLL
>NC_015737.1|WP_013977921.1|2156468_2157050_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MNTESNKPSVYDTMAGILAHMNGPQEKKNIAGHLAAIRNSIGKGYENTAEVWPIIFPLMPAEYLGNGAMTYEEKALLVTLQLYAIGQQGSNKTQGDRSRNFGSSLRNIRGIESAALDRRFNTMLTATTFEEFAYHLRQIFKLAKSKNTFSVNFPALAEDLFWYQKDKDKMVCLRWAREYYRPSLKKDTVSSDE
>NC_015737.1|WP_158309840.1|2154714_2156472_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MMGRFNLLDEPWISVLDGKTGEKRDVSLLEFFQNGGKYQTLAGDTETQNFAVMRFLLSIIQTVFSRFDFEGAVLPGVELDERWVQTESVDEDDLDEYCDAVSECWDRLYLNGSFPDVVSQYLEKWRDRFFLFDEVHPFYQVNQQEMNDIMELIPQKSQPTTIYGKNLNRTISESENKIALFSPIVQTGSGKRSKKDIMTSAQLVRWLITFQGYSGLADKVSLVNTVEKQRPSKGWLFDLGGVFLQGSNVFETLVMNYIPEFPANRKQLCGRIQNPCWEADGSLVVKRIYSGKQIDNLAELYTNWSRSIYIDPMMDMADPVEINIVKLPEIEHTENSIEPMTLWRWNENGPNKNHFTPKKHNAEQALWRSFGIIAMNPSSGESSRQFRPGIYGQYRRLAKVAGSRWTNLTGVSMADDGNATSWLPVDEISDSFMINDLVIADEEPDGWIVRINDVVETTKEVVSTIFKSYLRGICEIRDLKVTSPMDPNAAGFIEREIAEMYALIDSSFKEWICSIEPGDSKEEKIKSWNTQLRRQVLNRGEELYESSMMRDLTGIEKDNKIVNIATKYWQFVYRVNNKLGKGGAA
>NC_015737.1|WP_013977933.1|2170425_2170758_+|hypothetical-protein
MKQEEDRLSDDFTEYVQKLTEKVLKSPSLKRVTVGSSHELFQYFSEDLANVTKDIAGHFYSAGSQADIMPDATLITAKGKLDGERAIIIIRTDHKPAPFSSAAKDDVRIV
>NC_015737.1|WP_041727861.1|2170824_2171280_+|hypothetical-protein
MFIIEKKYTVDGKSEAILNSSWIHGDASMTDRQKENAVKRIIRKVQKETQDEMYIPKLKSVLSQNAVTESPVNVKEVIEDVIGQEADQYMKAEGVGEKDEMQNYSDSSKVTVTTDTGIRITAEADDVLKGKDIRIDDGKIIISGFSEYKIS
>NC_015737.1|WP_013977935.1|2171390_2171600_+|hypothetical-protein
MKKNFKEYMEGYDAALKLHHEAFHAYCMEMREAAPTAVKEALQTNYRTLLLAIRKQELDDLRKEQKGRG
>NC_015737.1|WP_148267871.1|2172040_2172301_+|preprotein-translocase-subunit-SecA
MVACASLIDELEQITLDEAADIVFVQDSTPAVENYHNYHGRRTAIIRCHRPEEKTYQYSAEETARRLHMTDMTFVKASGKTVEIQY
>NC_015737.1|WP_013977938.1|2172436_2172727_-|hypothetical-protein
MIGDHLLHGSNGKELGYLVEHLSWSKCDWGITEDLPKGVSGRLYDRNNRHDWRKGPIACTRIEGIITRNVKFWEDMVFYGHSRRKPFFVKTAYGVK
>NC_015737.1|WP_013977939.1|2172723_2172987_-|hypothetical-protein
METKRALNTQTLREEAFEPNIHDAIVDFKAGMDAQFIEHVEEKHLGVSNKYLRERITKGEWDDDLKKSFSLVNRRQSTASLHLSCVE
>NC_015737.1|WP_158309841.1|2173337_2173508_+|hypothetical-protein
MAAIIGVLIWLICLILVIYLTHKKNRSMVGMVIFAVFLPVIALIVILCMKPIPRVE
>NC_015737.1|WP_013977941.1|2173629_2174499_-|radical-SAM-protein
MNYEGIVYRPPSEARSLILQVTIGCAHNQCTFCTMYKAKNFRIRTLEEIRKDIHETAAAYGDIFRRIFLADGDALILPTETLLEILKELKQHFPSAERITSYGTPADVLRKTPDELKQLRSAGLAMVYMGAESGDDTVLSRIHKGVSSDEILAAGLRLRQSGIAVSVTLISGLGGRARIEEHAVASARLISGIRPEYVGFLTLMLDPAAPIRQELASGQMELLKPEELVDEMELFLRKVDAPGTVFRSNHASNYMMLKGTLNDDIPAMLARLADIRAHKGYRKESWRAL
>NC_015737.1|WP_013977943.1|2174794_2175616_-|hypothetical-protein
MSKVPCTNADKQKSYYKFYAADGYWGEQEKYSQITKEPLDPATAPRIEDRNDLFLPGYLPGEFGWWKLENGTAVIANKTFFPNTTGEMFDWWFAWHPIDRLRYACWNNEDHYDVYLEDPARALDMTKSMRERHWGSVHHIWEDIGLPGGAGMLIIAFKRPSELGYDESKIDTDACSTLVCAKTTIVGDDQTPDLDVVMTHFLRPAEGGSELRSRFWFGYTIDDNGKAVKTIPDGFTVPDAGPYCLLNHNVKEFSNLAKILPDLYAEEKDHWAV
>NC_015737.1|WP_013977944.1|2175798_2176749_-|LysR-family-transcriptional-regulator
MHNALSTLTLQQINIFLTVVDANGFARAGEVLHMTQPAVSKSIAKMEKNLNLRLFTRTTRSHALTEAGQMLYDAWKPLIGQMDRSYLQTCRLLEANNHTLSLGVLSTARPDLYFHPLIRRMQELHPEIHLTYEFDYMTNLERDLASAQKYDLILIPDFERFYINTLHLPYRYAAFDHMYLLLSKTHPLAAKTSVTTPDFADEPMVQIITHEDGQYYLQDLTERLARFRKTPQIGYTFRNAYDIRYLFTSSHAILLADNYFDYSTDQMDMVKLRIEDQFGGIICVWDPENRKQSLQYFLDLLPDLPSENKNAPAEAE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_015737_5	5.1\|1391215\|31\|NC_015737\|CRISPRCasFinder	1391215-1391245	31	NC_015737.1	1391258-1391288	0	1.0

1. spacer 5.1|1391215|31|NC_015737|CRISPRCasFinder matches to position: 1391258-1391288, mismatch: 0, identity: 1.0

tgctgtgccgctggatttttatcgcttctgc	CRISPR spacer
tgctgtgccgctggatttttatcgcttctgc	Protospacer
*******************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_015737_4	4.2\|1046168\|27\|NC_015737\|PILER-CR	1046168-1046194	27	MN693794	Marine virus AFVG_250M688, complete genome	15240-15266	3	0.889
NC_015737_1	1.1\|595072\|27\|NC_015737\|CRISPRCasFinder	595072-595098	27	NZ_CP017148	Bosea vaviloviae strain Vaf18 plasmid unnamed1, complete sequence	209260-209286	4	0.852
NC_015737_4	4.2\|1046168\|27\|NC_015737\|PILER-CR	1046168-1046194	27	NC_014653	Photobacterium damselae subsp. damselae virulence plasmid pPHDD1, complete sequence, isolate RM71	110579-110605	5	0.815
NC_015737_4	4.2\|1046168\|27\|NC_015737\|PILER-CR	1046168-1046194	27	NC_013940	Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence	293590-293616	5	0.815
NC_015737_6	6.29\|2163237\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2163237-2163269	33	NC_049953	Escherichia phage Lambda_ev099 genome assembly, chromosome: 1	46264-46296	5	0.848
NC_015737_4	4.2\|1046168\|27\|NC_015737\|PILER-CR	1046168-1046194	27	MN693677	Marine virus AFVG_250M686, complete genome	30900-30926	6	0.778
NC_015737_4	4.2\|1046168\|27\|NC_015737\|PILER-CR	1046168-1046194	27	MK448971	Streptococcus phage Javan52, complete genome	21295-21321	6	0.778
NC_015737_6	6.9\|2162017\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2162017-2162049	33	NZ_CP006906	Clostridium baratii str. Sullivan plasmid pCBJ, complete sequence	132851-132883	6	0.818
NC_015737_4	4.2\|1046168\|27\|NC_015737\|PILER-CR	1046168-1046194	27	NZ_CP040756	Paracoccus sp. 2251 plasmid unnamed9, complete sequence	4934-4960	7	0.741
NC_015737_6	6.29\|2163237\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2163237-2163269	33	NZ_CP050138	Sphingomonas sp. CL5.1 plasmid pTSSC1, complete sequence	116018-116050	7	0.788
NC_015737_6	6.49\|2164457\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2164457-2164489	33	NZ_CP012265	Cronobacter condimenti 1330 strain LMG 26250 plasmid pCCO1, complete sequence	22687-22719	7	0.788
NC_015737_6	6.56\|2164884\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2164884-2164916	33	NZ_CP013043	Clostridium perfringens strain JP55 plasmid pJFP55H, complete sequence	21541-21573	7	0.788
NC_015737_6	6.13\|2162261\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2162261-2162293	33	KY984068	Erwinia phage vB_EamM_Y3, complete genome	190753-190785	8	0.758
NC_015737_6	6.49\|2164457\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2164457-2164489	33	NZ_CP049700	Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2a, complete sequence	307312-307344	8	0.758
NC_015737_7	7.8\|2166958\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2166958-2166990	33	NC_016587	Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence	330629-330661	8	0.758
NC_015737_7	7.8\|2166958\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2166958-2166990	33	NZ_CP029833	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence	71806-71838	8	0.758
NC_015737_7	7.8\|2166958\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2166958-2166990	33	NC_013858	Azospirillum sp. B510 plasmid pAB510d, complete sequence	232764-232796	8	0.758
NC_015737_8	8.9\|2169154\|33\|NC_015737\|CRISPRCasFinder,CRT,PILER-CR	2169154-2169186	33	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	175793-175825	8	0.758
NC_015737_8	8.16\|2169581\|33\|NC_015737\|CRISPRCasFinder,CRT,PILER-CR	2169581-2169613	33	NZ_AP018263	Calothrix sp. NIES-4071 plasmid plasmid8 DNA, complete genome	2947-2979	8	0.758
NC_015737_3	3.3\|1014549\|34\|NC_015737\|PILER-CR	1014549-1014582	34	NC_014908	Alicycliphilus denitrificans BC plasmid pALIDE01, complete sequence	27636-27669	9	0.735
NC_015737_6	6.11\|2162139\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2162139-2162171	33	NZ_CP013691	Myroides odoratimimus strain PR63039 plasmid p63039, complete sequence	29053-29085	9	0.727
NC_015737_6	6.31\|2163359\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2163359-2163391	33	NZ_CP009691	Bacillus mycoides strain ATCC 6462 plasmid pBMX_1, complete sequence	345006-345038	9	0.727
NC_015737_6	6.31\|2163359\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2163359-2163391	33	NZ_CP009691	Bacillus mycoides strain ATCC 6462 plasmid pBMX_1, complete sequence	356952-356984	9	0.727
NC_015737_6	6.41\|2163969\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2163969-2164001	33	NZ_CP028351	Pantoea vagans strain PV989 plasmid pPV989-167, complete sequence	150289-150321	9	0.727
NC_015737_6	6.41\|2163969\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2163969-2164001	33	NC_014561	Pantoea vagans C9-1 plasmid pPag1, complete sequence	161755-161787	9	0.727
NC_015737_6	6.50\|2164518\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2164518-2164550	33	NC_048053	Dickeya phage vB_DsoM_JA29, complete genome	156945-156977	9	0.727
NC_015737_8	8.14\|2169459\|33\|NC_015737\|CRISPRCasFinder,CRT,PILER-CR	2169459-2169491	33	NZ_CP017563	Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence	553934-553966	9	0.727
NC_015737_3	3.3\|1014549\|34\|NC_015737\|PILER-CR	1014549-1014582	34	NZ_CP021649	Acidovorax sp. T1 plasmid p1-T1, complete sequence	113202-113235	10	0.706
NC_015737_6	6.9\|2162017\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2162017-2162049	33	NZ_CP013134	Rickettsia rhipicephali strain HJ#5 plasmid pHJ51, complete sequence	14637-14669	10	0.697
NC_015737_6	6.11\|2162139\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2162139-2162171	33	MN692993	Marine virus AFVG_117M87, complete genome	7588-7620	10	0.697
NC_015737_6	6.49\|2164457\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2164457-2164489	33	NZ_CP018172	Mesorhizobium oceanicum strain B7 plasmid unnamed1, complete sequence	125074-125106	10	0.697
NC_015737_6	6.52\|2164640\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2164640-2164672	33	NC_020275	Mycobacterium intracellulare subsp. yongonense 05-1390 plasmid pMyong1, complete sequence	114239-114271	10	0.697
NC_015737_7	7.7\|2166897\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2166897-2166929	33	NZ_CP033579	Vibrio mediterranei strain 117-T6 plasmid unnamed, complete sequence	33905-33937	10	0.697
NC_015737_7	7.8\|2166958\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2166958-2166990	33	CP006583	Mesorhizobium huakuii 7653R plasmid pMHb, complete sequence	254040-254072	10	0.697
NC_015737_7	7.8\|2166958\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2166958-2166990	33	NZ_CP053710	Acetobacteraceae bacterium strain PAMC 26569 plasmid unnamed2, complete sequence	343879-343911	10	0.697
NC_015737_7	7.8\|2166958\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2166958-2166990	33	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	899560-899592	11	0.667
NC_015737_7	7.8\|2166958\|33\|NC_015737\|PILER-CR,CRISPRCasFinder,CRT	2166958-2166990	33	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1232816-1232848	11	0.667

1. spacer 4.2|1046168|27|NC_015737|PILER-CR matches to MN693794 (Marine virus AFVG_250M688, complete genome) position: , mismatch: 3, identity: 0.889

aaaacaaccaaaacaaattggaaaatc	CRISPR spacer
aaaacaaccaagacaaattggcaaata	Protospacer
***********.********* ****

2. spacer 1.1|595072|27|NC_015737|CRISPRCasFinder matches to NZ_CP017148 (Bosea vaviloviae strain Vaf18 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.852

ttgattgcccggctgatccgatcttcc	CRISPR spacer
tggattgcccggctgatccgctcctcg	Protospacer
* ****************** **.**

3. spacer 4.2|1046168|27|NC_015737|PILER-CR matches to NC_014653 (Photobacterium damselae subsp. damselae virulence plasmid pPHDD1, complete sequence, isolate RM71) position: , mismatch: 5, identity: 0.815

aaaacaaccaaaacaaattggaaaatc	CRISPR spacer
taaacaaccaatacaaattggaactcc	Protospacer
 ********** ***********  .*

4. spacer 4.2|1046168|27|NC_015737|PILER-CR matches to NC_013940 (Deferribacter desulfuricans SSM1 megaplasmid pDF308, complete sequence) position: , mismatch: 5, identity: 0.815

aaaacaaccaaaacaaattggaaaatc	CRISPR spacer
agaacaacaaaaacaaattgaaaaaca	Protospacer
*.****** ***********.****.

5. spacer 6.29|2163237|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NC_049953 (Escherichia phage Lambda_ev099 genome assembly, chromosome: 1) position: , mismatch: 5, identity: 0.848

-tatcgcatccatgccagcgcttccggttctggc	CRISPR spacer
atatttcat-catgccagcgagtccggttctggc	Protospacer
 ***. *** **********  ************

6. spacer 4.2|1046168|27|NC_015737|PILER-CR matches to MN693677 (Marine virus AFVG_250M686, complete genome) position: , mismatch: 6, identity: 0.778

aaaacaaccaaaacaaattggaaaatc	CRISPR spacer
caaacaaccaaaacaaattgatggatt	Protospacer
 *******************. ..**.

7. spacer 4.2|1046168|27|NC_015737|PILER-CR matches to MK448971 (Streptococcus phage Javan52, complete genome) position: , mismatch: 6, identity: 0.778

aaaacaaccaaaacaaattggaaaatc	CRISPR spacer
taagcaaccaaaacaagttggaaatgt	Protospacer
 **.************.*******  .

8. spacer 6.9|2162017|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006906 (Clostridium baratii str. Sullivan plasmid pCBJ, complete sequence) position: , mismatch: 6, identity: 0.818

ctcttccataatttcgaaaatatcatatggttc-	CRISPR spacer
ctcttccataatatcgaaaatatc-tctagctaa	Protospacer
************ *********** * *.*.*

9. spacer 4.2|1046168|27|NC_015737|PILER-CR matches to NZ_CP040756 (Paracoccus sp. 2251 plasmid unnamed9, complete sequence) position: , mismatch: 7, identity: 0.741

aaaacaaccaaaacaaattggaaaatc	CRISPR spacer
taaacaaccaaaacaaattgccatggt	Protospacer
 *******************  * . .

10. spacer 6.29|2163237|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP050138 (Sphingomonas sp. CL5.1 plasmid pTSSC1, complete sequence) position: , mismatch: 7, identity: 0.788

tatcgcatccatgccagcgcttccggttctggc	CRISPR spacer
tggcgcatccttgccagcgattccggtggttgc	Protospacer
*. ******* ******** *******  * **

11. spacer 6.49|2164457|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012265 (Cronobacter condimenti 1330 strain LMG 26250 plasmid pCCO1, complete sequence) position: , mismatch: 7, identity: 0.788

cgccgcgccgccgcaattctctg-cgcacggaag	CRISPR spacer
cgccgcgctgccgcacttctctgccacaccggg-	Protospacer
********.****** ******* *.*** *..

12. spacer 6.56|2164884|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013043 (Clostridium perfringens strain JP55 plasmid pJFP55H, complete sequence) position: , mismatch: 7, identity: 0.788

taattgcactatctttgatattttgtaaattca	CRISPR spacer
taatttcaatatctttgatatttttatttttca	Protospacer
***** ** ***************     ****

13. spacer 6.13|2162261|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to KY984068 (Erwinia phage vB_EamM_Y3, complete genome) position: , mismatch: 8, identity: 0.758

tgcgcaatcacgtttttgttttcttccggcaat	CRISPR spacer
ttcgctattacgtttttgttttcttcgaagaag	Protospacer
* *** **.***************** .. **

14. spacer 6.49|2164457|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049700 (Bradyrhizobium sp. 1S5 strain 323S2 plasmid pB323S2a, complete sequence) position: , mismatch: 8, identity: 0.758

cgccgcgccgccgcaattctctgcgcacggaag	CRISPR spacer
cgccgcgccgctgcaattttctgctcgagctgg	Protospacer
***********.******.***** *. *  .*

15. spacer 7.8|2166958|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NC_016587 (Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence) position: , mismatch: 8, identity: 0.758

caggaggctgaccagattgccgacattcttagc	CRISPR spacer
ggcggggcagaccagattgccgacattctcgac	Protospacer
 . *.*** ********************...*

16. spacer 7.8|2166958|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029833 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.758

caggaggctgaccagattgccgacattcttagc	CRISPR spacer
ggcggggcagaccagattgccgacattctcgac	Protospacer
 . *.*** ********************...*

17. spacer 7.8|2166958|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NC_013858 (Azospirillum sp. B510 plasmid pAB510d, complete sequence) position: , mismatch: 8, identity: 0.758

caggaggctgaccagattgccgacattcttagc	CRISPR spacer
ggcggggcagaccagattgccgacattctcgac	Protospacer
 . *.*** ********************...*

18. spacer 8.9|2169154|33|NC_015737|CRISPRCasFinder,CRT,PILER-CR matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 8, identity: 0.758

cggtcatagcagtccggacagatgaacggatgc	CRISPR spacer
gcggcggcgcagtccgggcagttgaacggatgc	Protospacer
  * *.  *********.*** ***********

19. spacer 8.16|2169581|33|NC_015737|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018263 (Calothrix sp. NIES-4071 plasmid plasmid8 DNA, complete genome) position: , mismatch: 8, identity: 0.758

cacttttaacgggttttgttaaatccaatttcg	CRISPR spacer
acccgttaacgggttttgttaaatcaaatattt	Protospacer
  *. ******************** *** *.

20. spacer 3.3|1014549|34|NC_015737|PILER-CR matches to NC_014908 (Alicycliphilus denitrificans BC plasmid pALIDE01, complete sequence) position: , mismatch: 9, identity: 0.735

aaaatttcgcagc----ctgtccagcattttctccgga	CRISPR spacer
----tcccgcaatgagactgtccagcattttctcggga	Protospacer
    *..****..    ***************** ***

21. spacer 6.11|2162139|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013691 (Myroides odoratimimus strain PR63039 plasmid p63039, complete sequence) position: , mismatch: 9, identity: 0.727

ttgaaagaaaggcaggagaaaaaagatgactga	CRISPR spacer
atgaaagaaagggaagagaaaaaagaaaataat	Protospacer
 *********** *.*********** .*. .

22. spacer 6.31|2163359|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009691 (Bacillus mycoides strain ATCC 6462 plasmid pBMX_1, complete sequence) position: , mismatch: 9, identity: 0.727

cgatgtggatgccttcgcggaagcgtatcttgc	CRISPR spacer
agatatggatgcctttgcggaagcgatgcgaga	Protospacer
 ***.**********.*********   *  *

23. spacer 6.31|2163359|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009691 (Bacillus mycoides strain ATCC 6462 plasmid pBMX_1, complete sequence) position: , mismatch: 9, identity: 0.727

cgatgtggatgccttcgcggaagcgtatcttgc	CRISPR spacer
agatatggatgcctttgcggaagcgatgcgaga	Protospacer
 ***.**********.*********   *  *

24. spacer 6.41|2163969|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028351 (Pantoea vagans strain PV989 plasmid pPV989-167, complete sequence) position: , mismatch: 9, identity: 0.727

ccagccatacacagcggcaatttttcccggcaa	CRISPR spacer
gtacgattacactgcagcaatttttcccggcca	Protospacer
 .*    ***** **.*************** *

25. spacer 6.41|2163969|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NC_014561 (Pantoea vagans C9-1 plasmid pPag1, complete sequence) position: , mismatch: 9, identity: 0.727

ccagccatacacagcggcaatttttcccggcaa	CRISPR spacer
gtacgattacactgcagcaatttttcccggcca	Protospacer
 .*    ***** **.*************** *

26. spacer 6.50|2164518|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NC_048053 (Dickeya phage vB_DsoM_JA29, complete genome) position: , mismatch: 9, identity: 0.727

tgctgagaaaggcaaacaaaaaaatgtcgttgg	CRISPR spacer
cagcggtaaaggcaaacataaaaatgttgttgc	Protospacer
.. .*. *********** ********.****

27. spacer 8.14|2169459|33|NC_015737|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017563 (Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence) position: , mismatch: 9, identity: 0.727

cgggaaaacgttgatcgtttcaggcagatcggc	CRISPR spacer
ccaatgatggttgatcgtatcagggagatcggc	Protospacer
* .. .*  ********* ***** ********

28. spacer 3.3|1014549|34|NC_015737|PILER-CR matches to NZ_CP021649 (Acidovorax sp. T1 plasmid p1-T1, complete sequence) position: , mismatch: 10, identity: 0.706

aaaatttcgcagcctgtccagcattttctccgga	CRISPR spacer
gtcattttgcagcctgtccaacattttgttgagt	Protospacer
.  ****.************.****** *. .*

29. spacer 6.9|2162017|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013134 (Rickettsia rhipicephali strain HJ#5 plasmid pHJ51, complete sequence) position: , mismatch: 10, identity: 0.697

ctcttccataatttcgaaaatatcatatggttc	CRISPR spacer
aaaattaataatgtctaaaatatcatatggtag	Protospacer
    *. ***** ** ***************

30. spacer 6.11|2162139|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to MN692993 (Marine virus AFVG_117M87, complete genome) position: , mismatch: 10, identity: 0.697

ttgaaagaaaggcaggagaaaaaagatgactga	CRISPR spacer
aagaaaaaaaggaaggagaaaaaagaaaaggtc	Protospacer
  ****.***** ************* .*

31. spacer 6.49|2164457|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018172 (Mesorhizobium oceanicum strain B7 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.697

cgccgcgccgccgcaattctctgcgcacggaag	CRISPR spacer
atgggcgccgccgcaatactccgcgcactggcc	Protospacer
    ************* ***.****** *.

32. spacer 6.52|2164640|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NC_020275 (Mycobacterium intracellulare subsp. yongonense 05-1390 plasmid pMyong1, complete sequence) position: , mismatch: 10, identity: 0.697

tacggcgatcctgacggcctgggcgatctgcag	CRISPR spacer
ggcggcgatcttgccggcctgggcgaggccaaa	Protospacer
 .********.** ************  .  *.

33. spacer 7.7|2166897|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033579 (Vibrio mediterranei strain 117-T6 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.697

cgctggccgaagcgttcatagataaacatgaac	CRISPR spacer
ataacatcaaagcgtgcatagataaatatgaac	Protospacer
     ..*.****** **********.******

34. spacer 7.8|2166958|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to CP006583 (Mesorhizobium huakuii 7653R plasmid pMHb, complete sequence) position: , mismatch: 10, identity: 0.697

caggaggctgaccagattgccgacattcttagc	CRISPR spacer
cgccgggcagacaagattgccgacattctcgat	Protospacer
*.  .*** *** ****************....

35. spacer 7.8|2166958|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053710 (Acetobacteraceae bacterium strain PAMC 26569 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.697

caggaggctgaccagattgccgacattcttagc	CRISPR spacer
cgccgggcagacgagattgccgacattctcgat	Protospacer
*.  .*** *** ****************....

36. spacer 7.8|2166958|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 11, identity: 0.667

caggaggctgaccagattgccgacattcttagc	CRISPR spacer
ggccgggcagacgagattgccgacattctcgat	Protospacer
 .  .*** *** ****************....

37. spacer 7.8|2166958|33|NC_015737|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 11, identity: 0.667

caggaggctgaccagattgccgacattcttagc	CRISPR spacer
ggccgggcagacgagattgccgacattctcgat	Protospacer
 .  .*** *** ****************....

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

42392 : 92475

Lactococcus_phage(16.67%)

capsid,transposase,protease,integrase

attL 58349:58392|attR 92564:92607

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013975993.1\|42392_43895_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	7.2e-93	49.2
WP_013975994.1\|44129_46619_+	alkaline phosphatase family protein	NA	NA	NA	NA
WP_013975995.1\|46757_47537_-	uridine phosphorylase	NA	NA	NA	NA
WP_013975996.1\|47716_48649_-	cysteine synthase A	A0A1X9I5K7	Streptococcus_phage	4.2e-91	60.2
WP_013975997.1\|48917_49352_+	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_041727500.1\|49451_50225_-	arginase family protein	NA	NA	NA	NA
WP_041728015.1\|50274_51069_-	anaerobic sulfite reductase subunit AsrB	NA	NA	NA	NA
WP_013976000.1\|51157_53026_-	anaerobic sulfite reductase subunit A	NA	NA	NA	NA
WP_013976001.1\|53018_53657_-	4Fe-4S dicluster domain-containing protein	NA	NA	NA	NA
WP_013976002.1\|53681_56483_-	molybdopterin-dependent oxidoreductase	A0A077SK27	Escherichia_phage	2.7e-45	25.5
WP_013976003.1\|56792_58214_-	MATE family efflux transporter	NA	NA	NA	NA
58349:58392	attL	NA	NA	NA	NA
WP_148267759.1\|59348_59675_-\|protease	ribosomal-processing cysteine protease Prp	NA	NA	NA	NA
WP_013976007.1\|59677_59875_-	hypothetical protein	Q4ZA73	Staphylococcus_virus	3.3e-14	65.0
WP_013976008.1\|59938_60244_-	hypothetical protein	NA	NA	NA	NA
WP_013976009.1\|60230_60434_-	hypothetical protein	NA	NA	NA	NA
WP_013976011.1\|60878_61049_-	hypothetical protein	NA	NA	NA	NA
WP_148267760.1\|61045_61417_-	hypothetical protein	NA	NA	NA	NA
WP_148267761.1\|61490_61979_-	hypothetical protein	NA	NA	NA	NA
WP_013976014.1\|62179_62371_-	D-alanine--D-alanine ligase	Q6SED4	Lactobacillus_prophage	5.8e-08	37.7
WP_158309827.1\|62367_62514_-	hypothetical protein	NA	NA	NA	NA
WP_013976016.1\|62532_62742_-	hypothetical protein	NA	NA	NA	NA
WP_013976017.1\|62773_63037_-	hypothetical protein	A0A1P8BMG7	Lactococcus_phage	2.3e-07	37.0
WP_013976018.1\|63064_63250_-	hypothetical protein	NA	NA	NA	NA
WP_148267762.1\|63612_64083_-	hypothetical protein	A0A1P8BMG7	Lactococcus_phage	3.2e-15	41.3
WP_013976021.1\|64073_64292_-	hypothetical protein	NA	NA	NA	NA
WP_158309828.1\|64304_65135_-\|capsid	minor capsid protein	D7RWC7	Brochothrix_phage	1.5e-23	39.0
WP_013976023.1\|65286_65922_-	phage scaffolding protein	A0A0A7S0J5	Clostridium_phage	5.8e-28	41.3
WP_013976024.1\|66375_66582_-	hypothetical protein	NA	NA	NA	NA
WP_013976025.1\|67122_68289_+\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	2.2e-25	26.9
WP_013976028.1\|68938_69232_-	hypothetical protein	NA	NA	NA	NA
WP_013976029.1\|69275_69494_-	hypothetical protein	NA	NA	NA	NA
WP_013976030.1\|69451_70231_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_013976031.1\|70487_71753_-	MFS transporter	NA	NA	NA	NA
WP_013976034.1\|72713_73823_-	butyrate kinase	NA	NA	NA	NA
WP_013976035.1\|73842_74847_-	phosphate acetyltransferase	NA	NA	NA	NA
WP_013976036.1\|75015_76542_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013976037.1\|76672_77701_+	hypothetical protein	NA	NA	NA	NA
WP_013976038.1\|77754_78582_-	hypothetical protein	NA	NA	NA	NA
WP_013976039.1\|78659_78950_-	hypothetical protein	NA	NA	NA	NA
WP_013976040.1\|79184_80900_-	FAD-binding protein	NA	NA	NA	NA
WP_013976041.1\|80911_81187_-	ferredoxin family protein	NA	NA	NA	NA
WP_013976042.1\|81199_82945_-	iron hydrogenase small subunit	NA	NA	NA	NA
WP_013976043.1\|83197_84004_-	acyl-[acyl-carrier-protein] thioesterase	NA	NA	NA	NA
WP_013976044.1\|84023_85106_-	acyl carrier protein	NA	NA	NA	NA
WP_013976045.1\|85116_86412_-	thiolase family protein	NA	NA	NA	NA
WP_013976046.1\|86620_87523_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_013976047.1\|87659_88766_+	hypothetical protein	NA	NA	NA	NA
WP_013976048.1\|88958_90494_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013976049.1\|90546_91347_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_041727507.1\|91324_92029_+\|integrase	tyrosine-type recombinase/integrase	A0A2I7SCV1	Paenibacillus_phage	1.6e-15	29.3
WP_083834927.1\|92301_92475_+\|integrase	tyrosine-type recombinase/integrase	A0A0A8WIE1	Clostridium_phage	5.8e-07	51.0
92564:92607	attR	NA	NA	NA	NA

DBSCAN-SWA_2

154435 : 174240

Clostridium_phage(70.59%)

capsid,terminase,plate,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013976116.1\|154435_155572_-\|plate	baseplate J/gp47 family protein	A0A0A8WFK0	Clostridium_phage	7.9e-60	38.5
WP_013976117.1\|155564_155981_-	DUF2634 domain-containing protein	A0A0A8WJV8	Clostridium_phage	9.7e-16	35.7
WP_013976118.1\|155982_156270_-	DUF2577 domain-containing protein	NA	NA	NA	NA
WP_013976119.1\|156259_158209_-	CHAP domain-containing protein	X5JAJ3	Clostridium_phage	2.0e-66	44.3
WP_013976120.1\|158237_159068_-	LysM peptidoglycan-binding domain-containing protein	X5J9Z8	Clostridium_phage	1.8e-16	29.0
WP_013976121.1\|159067_161278_-	hypothetical protein	H7BVH2	unidentified_phage	2.0e-35	24.8
WP_013976123.1\|161460_161895_-	hypothetical protein	X5JAB6	Clostridium_phage	1.5e-19	37.5
WP_013976124.1\|162003_162489_-	hypothetical protein	A0A0A8WJ62	Clostridium_phage	2.7e-09	25.4
WP_013976125.1\|162510_163848_-	hypothetical protein	X5JAJ1	Clostridium_phage	2.4e-76	36.4
WP_013976126.1\|163844_164057_-	hypothetical protein	NA	NA	NA	NA
WP_148267766.1\|164098_164542_-	hypothetical protein	A0A0A8WJT3	Clostridium_phage	2.6e-11	30.7
WP_013976128.1\|164538_164973_-	HK97 gp10 family phage protein	Q20DD1	Lactobacillus_phage	2.9e-15	35.4
WP_013976129.1\|164977_165358_-	hypothetical protein	NA	NA	NA	NA
WP_013976130.1\|165360_165720_-	hypothetical protein	NA	NA	NA	NA
WP_013976131.1\|165785_166775_-	hypothetical protein	A0A0A7RVZ1	Clostridium_phage	5.5e-110	59.6
WP_013976132.1\|166809_167445_-	phage scaffolding protein	A0A0A7S0J5	Clostridium_phage	7.3e-31	44.3
WP_041727518.1\|167596_167851_-	hypothetical protein	NA	NA	NA	NA
WP_013976134.1\|167945_168194_-	hypothetical protein	C1KFI4	Lactobacillus_virus	2.5e-19	55.0
WP_013976135.1\|168505_170035_-\|capsid	minor capsid protein	X5JAI9	Clostridium_phage	2.1e-87	46.2
WP_013976136.1\|170031_171546_-\|portal	phage portal protein	A0A0A7S0I9	Clostridium_phage	4.2e-141	54.7
WP_013976137.1\|171560_173093_-\|terminase	PBSX family phage terminase large subunit	S5MC58	Brevibacillus_phage	9.4e-141	63.4
WP_148267767.1\|173223_173424_-	hypothetical protein	NA	NA	NA	NA
WP_013976139.1\|173847_174240_+	type II toxin-antitoxin system HicB family antitoxin	A0A0C5AEN7	Bacteriophage	4.4e-18	40.0

DBSCAN-SWA_3

756406 : 766073

Erysipelothrix_phage(33.33%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013976659.1\|756406_758278_-	ribonuclease H-like domain-containing protein	A0A0K2SUJ2	Clostridium_phage	4.5e-20	34.9
WP_013976660.1\|758457_760035_-	recombinase family protein	Q6DMS5	Streptococcus_phage	4.6e-151	54.4
WP_013976661.1\|760019_761753_-	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	4.1e-68	45.5
WP_013976662.1\|761809_761974_-	hypothetical protein	NA	NA	NA	NA
WP_013976663.1\|761963_762389_-	hypothetical protein	NA	NA	NA	NA
WP_013976664.1\|762709_764029_-	CHAP domain-containing protein	H7BV84	unidentified_phage	3.5e-59	54.6
WP_013976665.1\|764029_764443_-\|holin	phage holin family protein	A0A2K5B2A2	Erysipelothrix_phage	4.4e-45	62.5
WP_013976666.1\|764459_766073_-	hypothetical protein	A0A075KQI0	Lactobacillus_phage	5.4e-22	40.0

DBSCAN-SWA_4

803018 : 859656

Klosneuvirus(16.67%)

transposase,tRNA,protease,integrase

attL 825429:825443|attR 854768:854782

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013976699.1\|803018_804944_-\|tRNA	lysine--tRNA ligase	A0A1V0SIS0	Klosneuvirus	1.0e-91	39.8
WP_013976700.1\|805074_805548_-	transcription elongation factor GreA	NA	NA	NA	NA
WP_013976701.1\|805688_806645_-\|tRNA	tRNA dihydrouridine synthase DusB	NA	NA	NA	NA
WP_013976702.1\|806815_807583_-	type III pantothenate kinase	NA	NA	NA	NA
WP_013976703.1\|807671_808022_-	hypothetical protein	NA	NA	NA	NA
WP_013976704.1\|808111_809086_-	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_013976705.1\|809261_810254_-	ornithine carbamoyltransferase	NA	NA	NA	NA
WP_013976706.1\|810273_811209_-	SPFH/Band 7/PHB domain protein	A0A2K9KZA2	Tupanvirus	7.5e-16	29.6
WP_013976707.1\|811241_811721_-	NfeD family protein	NA	NA	NA	NA
WP_148267779.1\|811807_813157_-	glucose-6-phosphate isomerase	NA	NA	NA	NA
WP_013976709.1\|813370_814450_+	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	NA	NA	NA	NA
WP_013976710.1\|814551_816315_-	bifunctional homocysteine S-methyltransferase/methylenetetrahydrofolate reductase	NA	NA	NA	NA
WP_013976711.1\|816345_817197_-	AmmeMemoRadiSam system radical SAM enzyme	NA	NA	NA	NA
WP_013976712.1\|817208_818525_-	AmmeMemoRadiSam system protein A	NA	NA	NA	NA
WP_013976713.1\|818562_818985_-	HIT family protein	B5LJ12	Mycobacterium_phage	2.3e-09	31.1
WP_013976714.1\|819072_819729_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_013976715.1\|819794_821201_-	FHA domain-containing protein	NA	NA	NA	NA
WP_013976716.1\|821222_821492_-	pilus assembly protein	NA	NA	NA	NA
WP_013976717.1\|821498_821939_-	prepilin peptidase	NA	NA	NA	NA
WP_013976718.1\|821968_822829_-	pilus assembly protein	NA	NA	NA	NA
WP_013976719.1\|823121_824723_-	hypothetical protein	NA	NA	NA	NA
WP_013976720.1\|824719_824899_-	hypothetical protein	NA	NA	NA	NA
WP_013976721.1\|824955_826188_-	hypothetical protein	NA	NA	NA	NA
825429:825443	attL	NA	NA	NA	NA
WP_013976722.1\|826204_827011_-	type II secretion system F family protein	NA	NA	NA	NA
WP_013976723.1\|826898_827264_-	type IV secretory pathway	NA	NA	NA	NA
WP_041727598.1\|827415_830475_+	hypothetical protein	NA	NA	NA	NA
WP_013976725.1\|830467_831040_+	hypothetical protein	NA	NA	NA	NA
WP_013976726.1\|831791_832163_+	plasmid mobilization relaxosome protein MobC	NA	NA	NA	NA
WP_013976727.1\|832120_833254_+	relaxase/mobilization nuclease domain-containing protein	NA	NA	NA	NA
WP_013976728.1\|833147_833912_+	hypothetical protein	NA	NA	NA	NA
WP_013976729.1\|833948_834137_+	hypothetical protein	NA	NA	NA	NA
WP_013976730.1\|834313_835558_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.2e-45	44.9
WP_013976731.1\|835671_835932_-	dehydrogenase	NA	NA	NA	NA
WP_013976732.1\|836132_836843_-	recombinase family protein	NA	NA	NA	NA
WP_013976734.1\|837016_837199_-	hypothetical protein	NA	NA	NA	NA
WP_013976735.1\|837200_840554_-	DEAD/DEAH box helicase family protein	NA	NA	NA	NA
WP_013976736.1\|840553_841588_-	Eco57I restriction-modification methylase domain-containing protein	NA	NA	NA	NA
WP_013976737.1\|841599_842526_-	hypothetical protein	NA	NA	NA	NA
WP_013976738.1\|842841_843450_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_148267844.1\|843670_843865_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_013976741.1\|843981_844662_+	recombinase family protein	NA	NA	NA	NA
WP_013976742.1\|844658_846302_+	recombinase family protein	A0A2I4R675	Erysipelothrix_phage	1.2e-24	23.9
WP_013976743.1\|846451_846748_-	hypothetical protein	NA	NA	NA	NA
WP_013976744.1\|846879_847260_-	TnpV protein	NA	NA	NA	NA
WP_013976745.1\|847280_847688_-	hypothetical protein	NA	NA	NA	NA
WP_041728358.1\|847671_849177_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_013976747.1\|849166_850897_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_083834959.1\|850915_852073_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_013976749.1\|852258_853056_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013976750.1\|853717_854104_-	HNH endonuclease	NA	NA	NA	NA
WP_083835052.1\|854229_854973_-	L-2-amino-thiazoline-4-carboxylic acid hydrolase	NA	NA	NA	NA
854768:854782	attR	NA	NA	NA	NA
WP_002576323.1\|855492_856242_-	ABC transporter permease	NA	NA	NA	NA
WP_002576324.1\|856234_857152_-	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	6.0e-42	43.2
WP_041728366.1\|857332_857959_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_041727604.1\|858504_859656_-\|transposase	IS91 family transposase	NA	NA	NA	NA

DBSCAN-SWA_5

1342340 : 1380913

uncultured_virus(40.0%)

transposase,integrase

attL 1379673:1379689|attR 1381156:1381172

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013977179.1\|1342340_1342664_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_013977182.1\|1343160_1343859_-	MIP family channel protein	NA	NA	NA	NA
WP_013977183.1\|1344014_1344578_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_041727588.1\|1344756_1346187_+\|transposase	ISLre2-like element ISClsp4 family transposase	NA	NA	NA	NA
WP_050979222.1\|1346581_1347355_+	hypothetical protein	NA	NA	NA	NA
WP_013977186.1\|1347538_1353199_+	Cna B-type domain-containing protein	NA	NA	NA	NA
WP_013977187.1\|1353798_1355043_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.2e-45	44.9
WP_083834971.1\|1355300_1355537_-	TRAP transporter large permease subunit	NA	NA	NA	NA
WP_013977189.1\|1355834_1356692_-	hypothetical protein	NA	NA	NA	NA
WP_013977190.1\|1357038_1358793_+\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_013977195.1\|1361485_1361839_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_013977196.1\|1361835_1362129_+	helix-turn-helix domain-containing protein	A0A088CD40	Shigella_phage	1.4e-08	40.4
WP_148267792.1\|1362231_1362564_+	hypothetical protein	NA	NA	NA	NA
WP_013977198.1\|1362656_1362797_+	hypothetical protein	NA	NA	NA	NA
WP_013977199.1\|1363165_1363654_+	hypothetical protein	NA	NA	NA	NA
WP_013977200.1\|1363644_1364190_+	hypothetical protein	NA	NA	NA	NA
WP_013977201.1\|1364192_1364930_+	hypothetical protein	NA	NA	NA	NA
WP_070097172.1\|1365049_1365682_+	helix-turn-helix transcriptional regulator	A0A2H4J6F9	uncultured_Caudovirales_phage	1.0e-08	47.9
WP_083835060.1\|1365875_1366016_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_148267794.1\|1366012_1366252_+	hypothetical protein	NA	NA	NA	NA
WP_013977204.1\|1366257_1366701_+	hypothetical protein	NA	NA	NA	NA
WP_013977206.1\|1367210_1367390_+	hypothetical protein	NA	NA	NA	NA
WP_013977187.1\|1367444_1368689_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.2e-45	44.9
WP_013977207.1\|1369111_1369327_+	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_148267795.1\|1371290_1371650_-	IS66 family insertion sequence element accessory protein TnpB	NA	NA	NA	NA
WP_013977211.1\|1371636_1372029_-	IS66 family insertion sequence hypothetical protein	NA	NA	NA	NA
WP_013977213.1\|1372870_1373239_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013977214.1\|1373243_1374116_+	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_013977215.1\|1374151_1374337_+	NAD-dependent DNA ligase	NA	NA	NA	NA
WP_013977216.1\|1375492_1375864_+	type II toxin-antitoxin system PemK/MazF family toxin	NA	NA	NA	NA
WP_013977217.1\|1375884_1379118_+	VaFE repeat-containing surface-anchored protein	NA	NA	NA	NA
WP_013977218.1\|1379359_1379563_+	hypothetical protein	NA	NA	NA	NA
1379673:1379689	attL	NA	NA	NA	NA
WP_013977219.1\|1379692_1380913_+\|integrase	site-specific integrase	H7BUX8	unidentified_phage	6.3e-71	37.3
WP_013977219.1\|1379692_1380913_+\|integrase	site-specific integrase	H7BUX8	unidentified_phage	6.3e-71	37.3
1381156:1381172	attR	NA	NA	NA	NA

DBSCAN-SWA_6

2653106 : 2657842

uncultured_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013978361.1\|2653106_2654135_+	3-deoxy-7-phosphoheptulonate synthase	A0A067ZJG7	Escherichia_phage	7.4e-49	34.9
WP_013978362.1\|2654131_2654671_-	NUDIX hydrolase	NA	NA	NA	NA
WP_013978363.1\|2654693_2655185_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.8e-44	61.4
WP_013978364.1\|2655323_2656004_-	7-cyano-7-deazaguanine synthase QueC	A0A1U9WRB5	Streptococcus_virus	8.0e-60	52.9
WP_013978365.1\|2656122_2656707_-	GTP cyclohydrolase I FolE	S4U0J3	uncultured_phage	2.3e-47	53.6
WP_013978366.1\|2656710_2657388_-	putative 7-carboxy-7-deazaguanine synthase QueE	S4TZT1	uncultured_phage	1.7e-41	43.6
WP_013978367.1\|2657422_2657842_-	6-carboxytetrahydropterin synthase QueD	J9PV91	Bacillus_phage	6.3e-07	31.6

DBSCAN-SWA_7

2702616 : 2743829

Leptospira_phage(20.0%)

transposase,integrase

attL 2719337:2719352|attR 2726572:2726587

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013978411.1\|2702616_2702988_+\|transposase	transposase	NA	NA	NA	NA
WP_173363206.1\|2703225_2704449_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	8.0e-42	43.3
WP_013977274.1\|2704588_2705971_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	5.1e-29	30.8
WP_013978414.1\|2706170_2707604_-	adenylosuccinate lyase	NA	NA	NA	NA
WP_013978415.1\|2707705_2708587_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	2.7e-39	34.2
WP_013978416.1\|2708656_2710204_-	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	NA	NA	NA	NA
WP_041729178.1\|2710293_2711043_-	triose-phosphate isomerase	NA	NA	NA	NA
WP_013978418.1\|2711093_2712299_-	phosphoglycerate kinase	NA	NA	NA	NA
WP_013978420.1\|2712568_2713582_-	type I glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_013978421.1\|2713783_2714587_+	histidinol-phosphatase HisJ family protein	NA	NA	NA	NA
WP_083835036.1\|2714778_2716647_-	fibronectin type III domain-containing protein	A0A2K9V3I9	Faecalibacterium_phage	5.0e-11	28.9
WP_013978423.1\|2716880_2717438_-	elongation factor P	NA	NA	NA	NA
WP_013978424.1\|2717517_2717973_-	ribose 5-phosphate isomerase B	NA	NA	NA	NA
WP_013978425.1\|2717969_2718569_-	YqeG family HAD IIIA-type phosphatase	NA	NA	NA	NA
WP_013978426.1\|2718568_2719033_-	transcriptional repressor NrdR	NA	NA	NA	NA
WP_013978427.1\|2719055_2720156_-	redox-regulated ATPase YchF	NA	NA	NA	NA
2719337:2719352	attL	NA	NA	NA	NA
WP_013978428.1\|2720264_2721395_-\|integrase	site-specific integrase	A0A2H4JCB7	uncultured_Caudovirales_phage	3.7e-33	27.5
WP_041729184.1\|2721525_2721735_-	hypothetical protein	NA	NA	NA	NA
WP_013978430.1\|2721769_2721970_-	hypothetical protein	NA	NA	NA	NA
WP_050979245.1\|2722365_2723226_-	hypothetical protein	NA	NA	NA	NA
WP_148267823.1\|2723258_2725703_-	type II restriction endonuclease subunit M	NA	NA	NA	NA
WP_013978433.1\|2725930_2727121_-\|transposase	IS66 family transposase	S5VTD3	Leptospira_phage	1.0e-46	31.7
2726572:2726587	attR	NA	NA	NA	NA
WP_013978434.1\|2727715_2728318_-	hypothetical protein	NA	NA	NA	NA
WP_013978435.1\|2728310_2729282_-	hypothetical protein	S5VKI3	Leptospira_phage	1.6e-56	37.2
WP_013978436.1\|2729253_2729772_-	hypothetical protein	NA	NA	NA	NA
WP_013978438.1\|2730252_2730438_-	hypothetical protein	NA	NA	NA	NA
WP_148267825.1\|2730628_2731435_-	hypothetical protein	NA	NA	NA	NA
WP_013978440.1\|2731586_2731748_-	hypothetical protein	NA	NA	NA	NA
WP_013978441.1\|2731788_2732322_-	VanZ family protein	NA	NA	NA	NA
WP_013978442.1\|2732798_2734277_+	nucleotide sugar dehydrogenase	M1IB49	Acanthocystis_turfacea_Chlorella_virus	5.2e-104	50.5
WP_013978443.1\|2734455_2735835_-	ATP--cob(I)alamin adenosyltransferase	NA	NA	NA	NA
WP_041729192.1\|2735954_2736716_-	YdcF family protein	NA	NA	NA	NA
WP_013978445.1\|2736740_2737094_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	3.6e-19	46.8
WP_148267876.1\|2737394_2738528_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_013978447.1\|2738529_2740113_-	acyl CoA:acetate/3-ketoacid CoA transferase	NA	NA	NA	NA
WP_013978448.1\|2740226_2741504_-	MFS transporter	NA	NA	NA	NA
WP_013978449.1\|2741523_2742339_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_148267826.1\|2742617_2743829_+\|transposase	IS256 family transposase	A0A0N9STL0	Staphylococcus_phage	1.6e-39	38.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_015737

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection