CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_016943	Blastococcus saxobsidens DD2, complete genome	2 crisprs	cas3,csa3,DEDDh,Cas9_archaeal,casR,c2c9_V-U4,WYL,cas4	0	10	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_016943_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016943_1

1226405-1226857

Orphan

Consensus_repeat	Method
GTGCTCCCCGCGTCCGCGGGGGTGAGCC	PILER-CR
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	CRISPRCasFinder
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	CRT

7 spacers

DEDDh

The CRISPR arrays of NC_016943_1

>merge|NC_016943|1|1226405-1226857|PILER-CR,CRISPRCasFinder,CRT
GTGCTCCCCGCGTCCGCGGGGGTGAGCCCGTGTACATCGGCCCGGACGAGCCCCACTGGGCGTGCTCCCCGCGTCCGCGGGGGTGAGCCCACGTCGTCGGGCAACAACCACTCTGGACGGGAGTGCTCCCCGCGTCCGCGGGGGTGAGCCCGCCACCGCCCGGTCCTGGGGCAGCGCGCCGAGGTGCTCCCCGCGTCCGCGGGGGTGAGCCCGCGCGGCTGAACTCGTCAGCGGTGACCGCGGTGTGCTCCCCGCGTCCGCGGGGGTGAGCCCACCCCGAAGCGCGGGCAGGACGGCTACCACGAGTGCTCCTGCGTCCGCGGGGGTGAGCCCCGCTCACATACTGGGCCAGCAGGTCACGTGCCGTGTTCCCCGCGTCCGCGGGGGTGAGCCTCTCGGGCGCCGCCGCCCCAGAGGACGACAGGTGCTCCCCGCGTCCGCGGGGGGTGATCC

>NC_016943|1|1|1226405-1226797|PILER-CR
GTGCTCCCCGCGTCCGCGGGGGTGAGCC	CGTGTACATCGGCCCGGACGAGCCCCACTGGGC
GTGCTCCCCGCGTCCGCGGGGGTGAGCC	CACGTCGTCGGGCAACAACCACTCTGGACGGGA
GTGCTCCCCGCGTCCGCGGGGGTGAGCC	CGCCACCGCCCGGTCCTGGGGCAGCGCGCCGAG
GTGCTCCCCGCGTCCGCGGGGGTGAGCC	CGCGCGGCTGAACTCGTCAGCGGTGACCGCGGT
GTGCTCCCCGCGTCCGCGGGGGTGAGCC	CACCCCGAAGCGCGGGCAGGACGGCTACCACGAGTGCT
CCTGCGTCCGCGGGGGTGAGCCCCGCTC	ACATACTGGGCCAGCAGGTCACGTGCCGTGTTC
CCCGCGTCCGCGGGGGTGAGCC

>NC_016943|1|1|1226405-1226857|CRISPRCasFinder
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	GTGTACATCGGCCCGGACGAGCCCCACTGGGC
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	ACGTCGTCGGGCAACAACCACTCTGGACGGGA
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	GCCACCGCCCGGTCCTGGGGCAGCGCGCCGAG
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	GCGCGGCTGAACTCGTCAGCGGTGACCGCGGT
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	ACCCCGAAGCGCGGGCAGGACGGCTACCACG
AGTGCTCCTGCGTCCGCGGGGGTGAGCCC	CGCTCACATACTGGGCCAGCAGGTCACGTGCC
GTGTTCCCCGCGTCCGCGGGGGTGAGCCT	CTCGGGCGCCGCCGCCCCAGAGGACGACAG
GTGCTCCCCGCGTCCGCGGGGGGTGATCC

>NC_016943|1|1|1226405-1226857|CRT
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	GTGTACATCGGCCCGGACGAGCCCCACTGGGC
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	ACGTCGTCGGGCAACAACCACTCTGGACGGGA
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	GCCACCGCCCGGTCCTGGGGCAGCGCGCCGAG
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	GCGCGGCTGAACTCGTCAGCGGTGACCGCGGT
GTGCTCCCCGCGTCCGCGGGGGTGAGCCC	ACCCCGAAGCGCGGGCAGGACGGCTACCACG
AGTGCTCCTGCGTCCGCGGGGGTGAGCCC	CGCTCACATACTGGGCCAGCAGGTCACGTGCC
GTGTTCCCCGCGTCCGCGGGGGTGAGCCT	CTCGGGCGCCGCCGCCCCAGAGGACGACAG
GTGCTCCCCGCGTCCGCGGGGGGTGATCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016943.1\|WP_014375115.1\|1225784_1226249_-\|hypothetical-protein	unknown	unknown	unknown
NC_016943.1\|WP_014375117.1\|1228086_1229100_-\|NADPH:quinone-reductase	unknown	unknown	gnl\|CDD\|176215
NC_016943.1\|WP_014375109.1\|1216916_1218101_+\|hypothetical-protein	unknown	unknown	unknown
NC_016943.1\|WP_014375121.1\|1231579_1232014_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380340
NC_016943.1\|WP_014375124.1\|1235094_1236903_+\|phosphoenolpyruvate-synthase/pyruvate-phosphate-dikinase	unknown	unknown	gnl\|CDD\|181362
NC_016943.1\|WP_166486483.1\|1236914_1237994_+\|phosphoenolpyruvate-synthase	unknown	unknown	gnl\|CDD\|376527
NC_016943.1\|WP_083877941.1\|1214950_1215358_-\|MerR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|133398
NC_016943.1\|WP_014375108.1\|1216121_1216781_-\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
NC_016943.1\|WP_014375111.1\|1220007_1220634_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_016943.1\|WP_014375119.1\|1229515_1229932_-\|hypothetical-protein	unknown	unknown	unknown
NC_016943.1\|WP_014375114.1\|1224394_1225549_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NC_016943.1\|WP_014375116.1\|1226961_1227897_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NC_016943.1\|WP_014375118.1\|1229227_1229473_+\|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	unknown	unknown	gnl\|CDD\|171099
NC_016943.1\|WP_014375107.1\|1215354_1215594_-\|hypothetical-protein	unknown	unknown	unknown
NC_016943.1\|WP_014375113.1\|1222388_1224389_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NC_016943.1\|WP_014375122.1\|1232146_1232968_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|182100
NC_016943.1\|WP_041776140.1\|1230097_1231453_+\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|379017
NC_016943.1\|WP_014375112.1\|1220723_1222337_+\|acetyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|178415
NC_016943.1\|WP_014375110.1\|1218251_1219997_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237865
NC_016943.1\|WP_051005136.1\|1233058_1235071_+\|acetoacetate--CoA-ligase	unknown	unknown	gnl\|CDD\|235134

Protein	Function_ID	Function_description	E-value
NC_016943.1\|WP_014375117.1\|1228086_1229100_-\|NADPH:quinone-reductase	gnl\|CDD\|176215	cd08253, zeta_crystallin, Zeta-crystallin with NADP-dependent quinone reductase activity (QOR). Zeta-crystallin is a eye lens protein with NADP-dependent quinone reductase activity (QOR). It has been cited as a structural component in mammalian eyes, but also has homology to quinone reductases in unrelated species. QOR catalyzes the conversion of a quinone and NAD(P)H to a hydroquinone and NAD(P+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.26341e-113
NC_016943.1\|WP_014375121.1\|1231579_1232014_-\|cupin-domain-containing-protein	gnl\|CDD\|380340	cd02210, cupin_BLR2406-like, Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to BLR2406, a Bradyrhizobium japonicum protein of unknown function with a cupin beta barrel domain. Proteins in this subfamily appear to align closest to RmlC carbohydrate epimerase which is involved in dTDP-L-rhamnose production, and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	5.67093e-35
NC_016943.1\|WP_014375124.1\|1235094_1236903_+\|phosphoenolpyruvate-synthase/pyruvate-phosphate-dikinase	gnl\|CDD\|181362	PRK08296, PRK08296, hypothetical protein; Provisional.	0
NC_016943.1\|WP_166486483.1\|1236914_1237994_+\|phosphoenolpyruvate-synthase	gnl\|CDD\|376527	pfam01326, PPDK_N, Pyruvate phosphate dikinase, PEP/pyruvate binding domain. This enzyme catalyzes the reversible conversion of ATP to AMP, pyrophosphate and phosphoenolpyruvate (PEP).	5.87056e-132
NC_016943.1\|WP_083877941.1\|1214950_1215358_-\|MerR-family-DNA-binding-protein	gnl\|CDD\|133398	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators. Helix-turn-helix (HTH) heavy metal resistance transcription regulators (HMRTR): MerR1 (mercury), CueR (copper), CadR (cadmium), PbrR (lead), ZntR (zinc), and other related proteins. These transcription regulators mediate responses to heavy metal stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	3.38467e-09
NC_016943.1\|WP_014375108.1\|1216121_1216781_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	5.37655e-115
NC_016943.1\|WP_014375111.1\|1220007_1220634_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.47298e-12
NC_016943.1\|WP_014375114.1\|1224394_1225549_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	3.11885e-167
NC_016943.1\|WP_014375116.1\|1226961_1227897_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	8.86406e-71
NC_016943.1\|WP_014375110.1\|1218251_1219997_+\|hypothetical-protein	gnl\|CDD\|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	9.13211e-08
NC_016943.1\|WP_014375113.1\|1222388_1224389_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NC_016943.1\|WP_014375122.1\|1232146_1232968_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|182100	PRK09834, PRK09834, DNA-binding transcriptional regulator.	1.30175e-55
NC_016943.1\|WP_041776140.1\|1230097_1231453_+\|IS4-family-transposase	gnl\|CDD\|379017	pfam13006, Nterm_IS4, Insertion element 4 transposase N-terminal. This family represents the N-terminal region of proteins carrying the transposase enzyme, DDE_Tnp_1 (that was Transposase_11), pfam01609, at the C-terminus. The full-length members are Insertion Element 4, IS4. Within the collection of E.coli strains, ECOR, the number of IS4 elements varies from zero to 14, with an average of 5 copies/strain.	1.30167e-33
NC_016943.1\|WP_014375112.1\|1220723_1222337_+\|acetyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
NC_016943.1\|WP_014375118.1\|1229227_1229473_+\|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	gnl\|CDD\|171099	PRK11409, PRK11409, YoeB-YefM toxin-antitoxin system antitoxin YefM.	4.14833e-11
NC_016943.1\|WP_051005136.1\|1233058_1235071_+\|acetoacetate--CoA-ligase	gnl\|CDD\|235134	PRK03584, PRK03584, acetoacetate--CoA ligase.	0

>NC_016943.1|WP_014375115.1|1225784_1226249_-|hypothetical-protein
MTTPPRIDPHPVPSLDVVESALVRVEGSYRTRASSLDTKNGLVLAAAGVLVALVGARPEIAGLIGQVIAVAAGAAAVRSLGLRVDKAIDVGLLRDRYLGVDPTTARLVLLNTRIDLQARDEQQLLVKLRFLRLAAALRLGASVAILVGAIVNLI
>NC_016943.1|WP_014375114.1|1224394_1225549_+|acyl-CoA-dehydrogenase-family-protein
MLDYRLSDETEALRKTVQEFAREVIAPQIGEFYERDEFPTEIVRQMGELGLFGLPFPEEYGGAGGTYFDLCVALEELARVDSSMAITVEAGVSLGAMPIYRFGTPEQKQEWLPRLCSGEALGAFGLTEPGGGSDAGATRTTARLEDGQWVINGSKAFITNSGTDLTQLVTVTAVTGTRPDGGKEISAIIVPSGTTGFTVGQRYSKVGWNASDTRELSFDDVSVPEENLVGERGRGYAQFLSILDEGRIAISALSVGLAQGCVDESVKYAGEREAFGQPIGKNQAVQFMIADMEVRASTARLAYYRAAEKMLRGEPFKREASIAKLYSSEIAMDNARYATQVHGGYGFMNEFPVGRFYRDAKILEIGEGTSEVQRMLIARDLGVG
>NC_016943.1|WP_014375113.1|1222388_1224389_+|ATP-grasp-domain-containing-protein
MFDTVLVANRGEIAVRVIRTLREMGIRSVAVYSDADAGALHTRLADVAVRLGPAPAAQSYLLVERVLAAAAETGAQAVHPGYGFLSENVEFARACESAGIVFIGPPVAAIEAMGDKIRAKQTVMAAGVPVVPGRSEPGMSDEEVAEAAVAAGFPVLLKPSAGGGGKGMRVVRSKDELPDAIAGARREARSSFGDDTLLVERYVGNSRHIEVQVLGDTHGTVIHLGERECSLQRRHQKVIEEAPSPLLDTSMRASMGRAAVEAAKAVGYTGAGTVEFIVDADRPRDFFFLEMNTRLQVEHPVTEAITGLDLVEQQIRVAAGERLPIDQSDVSLDGHAIEARLYAEDPARGFLPQAGTVLALIEPAGPGIRVDSSLAVGSVVGTDYDPMLAKVIAWGPDRETARARLVGALGRTAVLGVSTNAAFLRALLTDEDVVAGRLDTGLIERRGNDLTAADPVPESVYASAALALQLEAEPTGPVVDRFDVPDGWRLGEPAWTVRRLQAPGGEPVVIRLRGRAADAELCIGDGAPVPARAARYGDDLVVTVGDWTARYAVVHVGGSVWLAADGRVTELREQERLASSAAGAAAGDGVVTSPMPGTVTVVQASVGDEVEAGTPLLVVEAMKMEHVLTAPVAGTVAELGVTAGQTVALDERLALVMPKAPDQQEL
>NC_016943.1|WP_014375112.1|1220723_1222337_+|acetyl-CoA-carboxylase-subunit-beta
MDAPVLPRTLTADPAAAARNAAAHAGLVADLADQLRRVALGGGERARERHTARGKLLPRERVDALLDPGSPFLELSPLAAHGLYDGDAPAAGIITGIGRVAGRECVVVANDATVKGGTYYPMTVKKHLRAQEVALHNRLPCIYLVDSGGAFLPMQDEVFPDREHFGRIFFNQANLSKAGIAQIAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGPPLVKAATGEVVTAEDLGGGDLHSRVSGVTDHLADDDAHALQIVRQIVGTLGPREQRPWDVAPVEEPQYLPESLYEVVPPDPRTPYDVREVIARLVDGSRFAEFKPLYGQTLVTGFARLHGHPVGIIANNGVLFAESALKGAHFIELCDRRAIPLLFLQNITGFMVGRDYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSFGAGNYSMCGRAYSPRFLFTWPNARISVMGGEQAASVLAQVRRDGLEARGEEWPAEDEEAFKAPIRDQYESQGHPYYATARLWDDGVIDPAHTRTVLGLALSACANAPLEEVGYGVFRM
>NC_016943.1|WP_014375111.1|1220007_1220634_-|TetR/AcrR-family-transcriptional-regulator
MTTARSQAGPARSARDTALIADTRRPSRREQILQAAAQLFAERGARAVGVDDVGAAVGVTGPAIYRHFASKDAMLAEMLVRISERLADGARERISEAGPDPADELRALIDFQVEFALDNPALIVVHDRDLPSLADADAAQVRRLQRRYVEEWVAVLARLHPGADAAACRVRAHAVFGLINSTPHSAGRLGRPATGDLLRRMAWAAATG
>NC_016943.1|WP_014375110.1|1218251_1219997_+|hypothetical-protein
MLALIPAPLQTAGERAFFGELARWDTGGSVRAAVVASLPLVDGPLGRRQSDAVLLVPEGIAVIRVAEVVRQSGVVRATPEGSWTIAADDGPSQVLQLAGGGSTPLDGLMRAGMDTAVKLRRAGLEPGRIARLTVLVGEVTGLDPADGDLGEGDHVATLDPRSLLLAIARASRHAGVDNPRLWTTADVRAALEALEYPGRGPSVEELNGEAFPYSPYVLRRPQLLTPAAMNAAPKATPPAPQAAEPSPTPAPNPGDPLSATGVARAVAASVASAHAAAVAAAAPAAPAPGRTGQRDTVEVDGEPAPPAGDAGIGGLFGRERESAGATDGPVPPPSPRTAVLPATPGAEEPRVRPPLSPAWGATASGNRAEGGPSDGAARTRWVIAAVVLALVVLGATAAGVLLGGGDEGATPGTTAPVTESAPSGPAPGEVRTVDGTAYTLQAVQVDDTCAGHAYGQVAEFLAATDCTGLARALYSASVEGAPVVVSVSRVAMADTAIARELRELTDTDGSGNVSDLLREGVTYAGGPAKLSSAQYASAVSGPTVTVVETAWANPATTGSVAALDKAASDGLALPVPPPPGG
>NC_016943.1|WP_014375109.1|1216916_1218101_+|hypothetical-protein
MSTAPAPAAPAVPQAPGTLRAGLVHPVALVRWLWFAYMTPGRPGRATTQHELRWIYTAWLAAFLLKMVGSSWDVSWHFMWLRDDLAPPHLLNTVGTAGVVVLVLFHSYSGYGVDQRALRLMQVGIGTFLVAIPVDILNHRINGLDITSWSPSHALLYLGTAIMLAGALRGWWLYAAPGRLRDLVSLGLWLFFVENVVFPNQHQEYGVLSLEAYNAGRTTAEPSLLDFAAAQGQTPTMFMLPVSSWVHPAWLVCAGLLSLVVARKVVGLRWTATVVAVVYLGYRGVMWLGLVAMGFPPSVLPVVLIVGAVLVDVAVTRRIPGWAAGLVVAAGVYAVAFPLEMLGLLPPWSWWSALPVAVAFAVLWAGVDALAGSAWLARWRAADEPAATPERAVV
>NC_016943.1|WP_014375108.1|1216121_1216781_-|oligoribonuclease
MSGDVAESAGHLVWIDCEMTGLDIVKDKLIEVAVVVTDSELNVLDPGLDLIIAADDADLDGMDDVVVEMHRKSGLTDAVRASSLTVAEAEQQLLAYIKRWVPERRTAPLCGNSIGTDRGFLARDMPELDDHLHYRMVDVSSIKELARRWFPRVYFAQPPKGLAHRALADIIESVRELAYYRRTLFVAAPGPSSDRAKKASDAVVGSFADLLAAGDAGHA
>NC_016943.1|WP_014375107.1|1215354_1215594_-|hypothetical-protein
MVSTVPDRSVNLALLHGLDQADFTGKVALTAHNDHDAEQLEAAGVDVVLRPFHAAADSGAALLLDEVETRGHRNGTALD
>NC_016943.1|WP_083877941.1|1214950_1215358_-|MerR-family-DNA-binding-protein
MRHRGVVRGDAPRVRPLRNRYGRRPAPAEGPDVGPVGQRDASHAGRGEPTGRAARRQIIAVREDGGEPPHHVTALLDAHAADLDQRIAELTALREDIRGLRDRADGSDPARCAEDMVCHVLPVDRPPGPPEEPGR
>NC_016943.1|WP_014375116.1|1226961_1227897_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MRLRMLATAAVAVTALSACGSSSENAPETSAQEDAVETRSVSHVMGTTEVPAEPQRIVTLDTPHLDTALSLGVTPVGSVQSDVAGGLPDYLGDRTEGIEIVGSIEEPELEAIAALEPDLILSSSVRHEEIYDQLSEIAPTVLTDYEEGWQAIFSTTAEALGMAEEGEEALAEYESRAQEIGDALGADGASASIVRFLPDETRIYGPETFSGSILADVGFTLPELPYDEYSMVYISPELIDQADADIVFSTAYGDPGATTKGSVTAVWDFLEAVPDCAFEVDDDEWMLGIGPIGAGIVLDDVEAKLAGTNCL
>NC_016943.1|WP_014375117.1|1228086_1229100_-|NADPH:quinone-reductase
MRAITYTRPGGPDVLQLTDRPVPEPGPGEVRVRVAFSGVNPTDWKSRTTARPGPDGQVPNQDGSGTVDAVGQGVDPAMLGQRVWIWEAAWQRPWGTAAESTVVPARHVVLLGADPSFELGAALGIPFLTAHRCLTVAESLPDRLGPGALTGHTVLVQGGAGAVGNAAIQLARWSDATVIATVSSPHKAQLAAAAGADHVVNYQEQDVVAEVRTVAQKGVDAIVEVSAAVNAGVDAQVIGAHGAVAMYADDGGAEVTVPVRAQMGLNARWQFVLVYTEPERAKALGIEDVTTAVADGAVGVGEGAGLPLHVFPLAETAQAHQAVQDGAVGKVLIDVTH
>NC_016943.1|WP_014375118.1|1229227_1229473_+|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin
MAITVSAARQRLGSLIEEVDADQVAVAIVSKRGTAFLVSAHEYHSLKETVHLLQSPKNAQRLRESLSEVSAGGLAEDQAAR
>NC_016943.1|WP_014375119.1|1229515_1229932_-|hypothetical-protein
MGYFGTLVYSEGRWRTGRPTAVPFLMVDVHDSDIATVDYRAADATGGRFFLGYEPRVYFDEPDASVPVDTDAEAAGFARWVKDAVGTEVEPAELRGLMASPGGVPPTDEVVEQTVERLLVLAGLPVPEWPTDEDAPPG
>NC_016943.1|WP_041776140.1|1230097_1231453_+|IS4-family-transposase
MSQVVRVVNVAGGRFAPGHLGELTQIVPFEMVDAVLAKTGTVQQRVRDLPSRVVVYLLLSAVLFAECGYRQVWDRMTAALDGLPVPAPTPAALAAARRRIGAAPLRALFDLLRGPAAGPATKGVWWRGRLVTAIDGTTMCCPDTPANLVVYRKGGGHHGGTGYPMIRLLALVACGTRGLLATTFGTTGRGETGYATDLVPAMRAPMIVLADRNFAAADLLAQIADRGADLLVRVKTGRRLPVCARCADGSWLSRIGPLEVRVIRAEITITTPGGQRTEVYQLVTTVTDPDCPATELVRLYHERWEIETAYCELKQTIGDGRVLRARTPAGLEQEIYALLVAYQALRITIADATLTAPDVDPDRGSFTIALNTARDQLIKAAGVIAETTVDLLGGIGRQVLEHLLPDRRCRTSPRVVKRAISNYAPHTASGRLRGPSHKATISIDVLVHPDP
>NC_016943.1|WP_014375121.1|1231579_1232014_-|cupin-domain-containing-protein
MAQDQSSDTTDHWHRPLRHVRAAELSGDTGQSSGMTRKEAVSGKSVGAEKVWMGEAHVAPGTASANHHHGDSETGIYVVSGRPVFVFARDGEEVRLTPEPGDYVFVPPWTPHREENPGDEEAVVVLARSSQEAIVVNLPPGSLA
>NC_016943.1|WP_014375122.1|1232146_1232968_-|helix-turn-helix-domain-containing-protein
MREYRVKTIDSLARGLEVLRVLQEVRAASLHDLHLATGISKPTLTRILVTAYQHGLVWQRMVDGAFLPSHTLQRRMETDDSEWLVEIASPVLGELSRRLQWPSIFSVPRLDHMETLETNSSRTYFDGLPPRPHGFRVNMLGSASGRAYLAFCPEQELEAVLARLRLKKDPAYRLARDDAAVRRMVETTRRRGYGVRAPDFGGDHDRPRSEVDDGRESIAMPVRVDGRVVGCINLTWRRQVLSLPTAVQRHLEDLRTAVRTVEERARAAGLGHG
>NC_016943.1|WP_051005136.1|1233058_1235071_+|acetoacetate--CoA-ligase
MASSAADPATSPAVREGDLLWAPPPDRAERTRLAEFTRFAEARTGRSFPDYADLWTWSTVELEEFWQAVWDFFDVRSSAPHTAVLESPEMPGARWFPGARLNFAEHVLAQERPGQPALLAVSESNPLRAVPWEEFTRQVRAVATYLRERGVRPRDRVVAYLPNVPEAVVAMVATASVGAVWASCSPDFGSRGALDRLGQLEPTVLFAADGYRYGGRDFDRRGEIAELVAGLPSLREVVRVPVLGLEAPGTPWADVLAGPTVPAAEFVCEQVSFDHPLWVLFSSGTTGLPKAIVHGHGGILLEQLKLQAFHLDLRPGDRAFFFTTTGWMMWNFCVSMLLQGIVPVLYDGNPSHPDVDVLWRTAQDSRARLFGASPTFVELMQKAGVVPKERFDLSALEIVMPAGSPVSPAVTTWFYEAVGPDLWIATGSGGTDCCTGFVGGVPTLPVRAGEIQARSLGVAAESWDDAGHPVVGRVGELVITAPMPSMPLFFWGDDDGSRYRASYFETFPGVWRHGDFFELNERGGCFVRGRSDAVLNRQGVRIGTAEIYRVVEDDPAVLGALIVNLDLPDGGFFMPLFVSLTPGAQLDGELAGRLRRRLREECTPRHVPDAIVAVRAIPLTRSGKKMEIPVRRLLLGADTAAVADPHAMADPAALDDFVEYARTQRDYALR
>NC_016943.1|WP_014375124.1|1235094_1236903_+|phosphoenolpyruvate-synthase/pyruvate-phosphate-dikinase
MPERSFPLPSQIEAVPGAEGWEAMYPFFSRFQPEDDQRFWFYNSMHFPEVIPAFDGITSEIPYTAIGANTARLFSFPTTMGIEYRIINGRVYITANPVLDEAEQGRRFADFQERAGHYYANWDRIYGEWQQRIEALIADIEAVEVPELGELDPLEVVTGGRGFASNHYLRERFHRCIDLYSKMWHHHTELLMLGYGAYVVFFEFCKQAFPEMGDQMVARMVAGMDVTMYRPDDELKKLAALAVELDLGDLFVEGADPAKVLASLGERGDAGARWLAALEAAKDPWFNVSVGDGFYHHHLSWADDLTVPFAALPRYVEQIAVGEDLTRPTERLAEERDRIAGEYRALLDSEEEKAAFDQMLGLCRQVFPYIESHKFYCEHWFTTRFFQKIRAFGALLAERGVLLAADDVFHLRHLEVEDALVDVSLAWASGGTELGARHWQPIVAERKRIVEALSGWSPPPALGAVPEALNDPAVKMLWGITQDTIEAWLGGDDDDESTVRGYAASPGVVEGIARVLLNVNDIGQIREGEVLVCPVTAPSWGPVFGKIAAAVSDIGGTMSHAAIVAREYGMPAVVGTGMATARIKTGDRVRVDGDRGVVTVLS
>NC_016943.1|WP_166486483.1|1236914_1237994_+|phosphoenolpyruvate-synthase
MTTRSVLHFRDVGLGDVATVGGKGASLGELLRAGVRVPTGFAVTTSAFRQTVEHLTVHGESIPARVAALDPADAERLAAATAEIRAVLESAPPPDEVAAAVTAAYAALGEECGDPELPVAVRSSATSEDSAEASFAGLQDTYLWVRGADSVLEHVRRCWASLYSVESVTYRLRRGIPETDLGMAVVVQRMVGARSSGVMFTRSPRSGDKSVVAIDASWGLGSAVVSGDVTPDSFVVSKVTGEVRRTVATKTRWHRPDPSGSGVAESDVPAELQDQPSISDEEIAELVAIARQVEAHYGCPQDIEWAVAETAPAGENVFLLQSRPETVFAEKDRAAKAAPAARPFDHVFNLLGGQRPSRG

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Crispr_ID: NC_016943_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_016943_2

4845082-4845179

Orphan

Consensus_repeat	Method
GGGACGCCGTCCCCGTCCGTGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_016943_2

>merge|NC_016943|2|4845082-4845179|CRISPRCasFinder
GGGACGCCGTCCCCGTCCGTGTCCACCGGCTTCGTGGTCACGGAGGGGTCTCGCGGCGAGTAGTCCCTGCTGTCGGGGACGCCGTCCCCGTCGGTGTC

>NC_016943|2|2|4845082-4845179|CRISPRCasFinder
GGGACGCCGTCCCCGTCCGTGTC	CACCGGCTTCGTGGTCACGGAGGGGTCTCGCGGCGAGTAGTCCCTGCTGTCG
GGGACGCCGTCCCCGTCGGTGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_016943.1\|WP_014378685.1\|4848162_4848810_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_016943.1\|WP_014378690.1\|4853145_4854102_-\|matrixin-family-metalloprotease	unknown	unknown	gnl\|CDD\|334067
NC_016943.1\|WP_041775922.1\|4841222_4842299_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NC_016943.1\|WP_041776903.1\|4835064_4835355_-\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NC_016943.1\|WP_014378674.1\|4835923_4836274_-\|hypothetical-protein	unknown	unknown	unknown
NC_016943.1\|WP_014378679.1\|4840821_4841187_+\|hypothetical-protein	unknown	unknown	unknown
NC_016943.1\|WP_014378686.1\|4848904_4849984_+\|inositol-3-phosphate-synthase	unknown	unknown	gnl\|CDD\|132491
NC_016943.1\|WP_041775923.1\|4847587_4847983_-\|DUF5318-domain-containing-protein	unknown	unknown	gnl\|CDD\|379953
NC_016943.1\|WP_014378687.1\|4850105_4850867_+\|hypothetical-protein	unknown	unknown	unknown
NC_016943.1\|WP_014378677.1\|4836843_4837788_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173799
NC_016943.1\|WP_014374932.1\|4837900_4838722_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|366760
NC_016943.1\|WP_014378693.1\|4856266_4858651_+\|hypothetical-protein	unknown	unknown	unknown
NC_016943.1\|WP_051005101.1\|4843269_4844763_-\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|227937
NC_016943.1\|WP_014378681.1\|4842423_4843236_+\|deoxyribonuclease-IV	unknown	unknown	gnl\|CDD\|179214
NC_016943.1\|WP_041776908.1\|4854175_4855624_-\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|131739
NC_016943.1\|WP_014378689.1\|4851866_4853138_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_016943.1\|WP_014378672.1\|4834570_4835062_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|236092
NC_016943.1\|WP_014378692.1\|4855793_4856270_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239645
NC_016943.1\|WP_193345711.1\|4851035_4851557_-\|YqgE/AlgH-family-protein	unknown	unknown	gnl\|CDD\|234694
NC_016943.1\|WP_014378675.1\|4836270_4836606_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|273625

Protein	Function_ID	Function_description	E-value
NC_016943.1\|WP_014378685.1\|4848162_4848810_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	4.99012e-18
NC_016943.1\|WP_014378690.1\|4853145_4854102_-\|matrixin-family-metalloprotease	gnl\|CDD\|334067	pfam00413, Peptidase_M10, Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.	6.28431e-05
NC_016943.1\|WP_041775922.1\|4841222_4842299_-\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	3.37905e-05
NC_016943.1\|WP_014378675.1\|4836270_4836606_-\|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	gnl\|CDD\|273625	TIGR01439, Uncharacterized_protein_Mb2626, looped-hinge helix DNA binding domain, AbrB family. This DNA-binding domain family includes AbrB, a transition state regulator in Bacillus subtilis, whose DNA-binding domain structure in solution was determined by NMR. The domain binds DNA as a dimer in what is termed a looped-hinge helix fold. Some members of the family have two copies of the domain in tandem. The domain is found usually at the N-terminus of a small protein. This model excludes members of family TIGR02609. [Regulatory functions, DNA interactions].	0.000296409
NC_016943.1\|WP_014378692.1\|4855793_4856270_+\|NUDIX-hydrolase	gnl\|CDD\|239645	cd03673, Ap6A_hydrolase, Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most preferred substrate, hydrolyzes to produce two ATP molecules, which is a novel hydrolysis mode for Ap6A. These results indicate that Ap6A hydrolase is a diadenosine polyphosphate hydrolase. It requires the presence of a divalent cation, such as Mn2+, Mg2+, Zn2+, and Co2+, for activity. Members of the Nudix superfamily are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site.	4.07834e-44
NC_016943.1\|WP_014378681.1\|4842423_4843236_+\|deoxyribonuclease-IV	gnl\|CDD\|179214	PRK01060, PRK01060, endonuclease IV; Provisional.	7.55461e-97
NC_016943.1\|WP_014378686.1\|4848904_4849984_+\|inositol-3-phosphate-synthase	gnl\|CDD\|132491	TIGR03450, mycothiol_INO1, inositol 1-phosphate synthase, Actinobacterial type. This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.	0
NC_016943.1\|WP_041775923.1\|4847587_4847983_-\|DUF5318-domain-containing-protein	gnl\|CDD\|379953	pfam17249, DUF5318, Family of unknown function (DUF5318). This family of unknown function is mostly found in Actinobacteria.	2.62609e-74
NC_016943.1\|WP_014378677.1\|4836843_4837788_-\|S8-family-serine-peptidase	gnl\|CDD\|173799	cd07473, Peptidases_S8_Subtilisin_like, Peptidase S8 family domain in Subtilisin-like proteins. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	5.7916e-08
NC_016943.1\|WP_014374932.1\|4837900_4838722_-\|ATP-binding-protein	gnl\|CDD\|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	1.22539e-58
NC_016943.1\|WP_051005101.1\|4843269_4844763_-\|DUF2029-domain-containing-protein	gnl\|CDD\|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	3.78928e-63
NC_016943.1\|WP_041776903.1\|4835064_4835355_-\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	3.54747e-42
NC_016943.1\|WP_014378689.1\|4851866_4853138_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.08504e-34
NC_016943.1\|WP_014378672.1\|4834570_4835062_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	4.00023e-95
NC_016943.1\|WP_193345711.1\|4851035_4851557_-\|YqgE/AlgH-family-protein	gnl\|CDD\|234694	PRK00228, PRK00228, YqgE/AlgH family protein.	4.18956e-48
NC_016943.1\|WP_041776908.1\|4854175_4855624_-\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0

>NC_016943.1|WP_051005101.1|4843269_4844763_-|DUF2029-domain-containing-protein
MVVPRGTRPPERRDRVIPSWDDPVARQASEAVGGPWGRFAVTGRALFWTPLRVCLLLTTLAAAVAWLKQAPCSDGNWAGFVQYTHLCYSDGVPLFALYGLDEGAVPYLDSAVEYPVLTGGFMAVAAALSGLYDRAAAASGLLPAVPAVQSYYAVTCLLLTACAFLVVRSTLALAGRRPWDAAMIGLSPLVVVHAFTNWDLFAVALAGLGLWAWARSRPVLAGLLLGLGAAAKLYPVFLLLTLFLLCLRAGRLRTWVRTAAAAMAAWSAVNVPVALVAPEGWSRFFTLNRTRPVDPDSLWNIALHLSGNRLLDGPLAEGEAPTVLNAVVAVALLAGVAAVARLVRVAPVRPRVAQVAFLLVAVFLLTNKVWSPQYSLWLLPLAILARPRWRSLLAWQATEALLWVPRMLWYLGTENNGVAVEWFFVAVTVRDVAVVVLMALVVRDVLDPDRDVVRTSWPGVDDPAGGPLDRAPDRVLPRTARRDQVTWSSMVLPRRGP
>NC_016943.1|WP_014378681.1|4842423_4843236_+|deoxyribonuclease-IV
MGLHPIGVHVGAGLSDEGQLEHGGPLARAAEVDADGVQIFLTDPQSYAAPEPRPDAGELSSGDVMVVVHAPYLLNVASTNNRIRIPSRKLLDQHARAAAAVGARGLVVHGGHVLAKDDPSAGADNWRKTFARQVEQGGFPVPVLIENTAGGGNAMARDLDAIGRLWDAVGEFGAGFVLDTCHAWAAGWDLSTVVEAVRAVTGRIDLVHLNNSRDPAGSGRDRHAPLTDGEIPADLLFDVARRADCPIVLETPGDAASHAEEIALLRAALA
>NC_016943.1|WP_041775922.1|4841222_4842299_-|hypothetical-protein
MATGRIRRTARRGIAVAVLAWLGVAGASLVAPLAVAAPSVTVPIRDVTPPVVSVDAGGSVTFVNEIQDKTVQVGGGGLLPALVDVTASTEVTLGLPSGTKVLTAPGTPGASVTERFDRSCATCTLTYTYALTSNGSLTAPLTDAALEALPSLPAPTPFVVNTILPDVPDVQGANLPPLPAVTLPPLPVQPPAPPAPPVPGEDREETVVDTPPAAPPVMQDPPGDPYTYGAGAGAVRLSPSSTTAAAAFDPSRFAVPGQGPGGAGRAGSSGAGGVAGSYDGASVPVFGQLAGLDFAALDEGSASEVVTASEARPLTLPAAALAAVVALAAVTAALVRTSASTRRPGGDGNTVVWLGRSR
>NC_016943.1|WP_014378679.1|4840821_4841187_+|hypothetical-protein
MPKIPDSTKDSLHWRLATRARERWPDLAEVRMRYRTGLAYVDGILSGGEILPLCRLRYVGSATTWGFAIYRASHDDYEDNFLPTGSSSGTAEEALDCACGLCLNDPTACTTDPRPFNGGNH
>NC_016943.1|WP_014374932.1|4837900_4838722_-|ATP-binding-protein
MTAATRSASAVAVGPAVGTPAAPALPDDLETLLRRLRLPHVRRHAADVLATAKAQRWDPAEVLRVLLGEEVAGRDRSALATRRAAAAFPTGKTFDAWTPEASSIPAPTQQALRTLEWLHRRENLVICGPSGTGKTFLLEALGSSAVEQGLKVAWFTLEDLGLLVRRHRADDTVTKAIARVLRADLVVIDDIGLLPVATDAAEGLYRLVDAAYEKRSVAVSSNLHPAAFDELMPKTLATATVDRLLHHAHVCQTSGDSVRLSQALAGQGVRPLT
>NC_016943.1|WP_014378677.1|4836843_4837788_-|S8-family-serine-peptidase
MTPGCGFFGPAICGTYHQTYGISMAAPLVAGVAALARSANPELSAADIGSCIVSTAGRRTGTVAERGTVPGTGNAVLDFPVVGAPSLPIVDAEAAVKCAQGGLDGGGILVLGAGDRTGSGDGSDLGDLTQRLTEEGYEVSTSQTMPADLSGFDQVWHIDTQPLTGSEVDRLAAFVESGRSVYLTGEWGCCPIDQSTIGLINRLTGGNVGHGGENGTNTVPVNSDAIGNIDGTDTPNQVSTLQVATSGSLRGVPARSIVAAVPGDPTRAVWAAWDSSQVTGGGKVVALMDINWFAHQYRGDTWDEVTANIAKFLS
>NC_016943.1|WP_014378675.1|4836270_4836606_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein
MAVRTRRAEKAEECFHGYVTVQGRGTVALPVGLRKRYHLDRPGAQVEITEREDGVLELRPTLAVPVAEAWFWEERWQAGEREVDAHVAAGATTQHETVDDFVAHLDALDDE
>NC_016943.1|WP_014378674.1|4835923_4836274_-|hypothetical-protein
MRFETTPRFDSDYKDLKAEHKRQFREVLPDFIRACDAYAEAYAVSRDKDAVKEKVPAYRWPAALRVSPMKSAPGIWEMTWSFASPDGRATFEFVSDDQGLILRWRRIGDHSIYKRP
>NC_016943.1|WP_041776903.1|4835064_4835355_-|30S-ribosomal-protein-S6
MRHYELMVILDPDLEERTIAPSLDRFLTVITKSGGTVAKVDIWGRRRMAYEIQKQAEGIYAVIDIDAEPAAVSELDRQLNLNESVLRTKLMRPEVH
>NC_016943.1|WP_014378672.1|4834570_4835062_-|single-stranded-DNA-binding-protein
MAGETVITVIGNLTADPELRFTPSGAAVANFTVASTPRTFDRQSQEWKDGEALFLRCNVWRQAAENVAESLTRGSRVIVSGRLKQRSFDTKEGEKRTVIELEVDEIGPSLRYATAKVTKASRGEGGGGFGGGGGGGGGGFGGGGGGASDPWSTPAGPSDEPPF
>NC_016943.1|WP_041775923.1|4847587_4847983_-|DUF5318-domain-containing-protein
MDYSLQRRAVLAGVHAGRTGLFEVCDASPYLSRAAKYHGQPTDVACPVCRRERLTLVNYVYGEHLGPVAGQAKTEAELARMDAAQDEFSVYQVEVCRGCGWNHLDCSYVLGAEPEPGRQPRRGRRRTATEQ
>NC_016943.1|WP_014378685.1|4848162_4848810_+|PadR-family-transcriptional-regulator
MLEFAILGLLQQAPMHGYELRKQLAQVLGGLRSISYGSLYPALRRMQAAGLITTDEPAPRALLPADAPPLTGRRGKVVYTITADGKERFHELVSETGPEAYDDGGLFGVRLAFFRHTAQDARLRILEGRRRTVERQREGLRSSLSRTRERLDRYTLELQRHGLESVDREVRWLSELIDSERREASEPGTARREASGTSGAAALPDPPDGDPPGTT
>NC_016943.1|WP_014378686.1|4848904_4849984_+|inositol-3-phosphate-synthase
MGSVKVAIVGVGNCAASLVQGVHYYRDADETASVPGLMHVRFGEYHVSDIEFVAAFDVDAKKVGRDLSEAIVASENNTITICDVPPLGVTVQRGTTLDGLGKYYREMVEESDEQPVDVVAALRQAQADVLVCYLPVGSQQAAEFYAQAALDAGVAFVNALPVFIAGTKEWADKFTAAGVPIVGDDIKSQVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFKNMLERERLESKKISKTQAVTSQIERDMGVGNVHIGPSDHVPWLSDRKWAYVRLEGRAFGDVPLSLEYKLEVWDSPNSAGIIIDAVRAAKIAKDRGIGGPILSASAYFMKSPPVQYRDSEARDMVEAFIAGDAER
>NC_016943.1|WP_014378687.1|4850105_4850867_+|hypothetical-protein
MPASRPLLRRVGAAGLAAVLLSGCGSEERRAGEPITAEDAAVLAELLHHNHEEGGADFVATVPFSEDALLTLTGEIDFRRGAGQAQAVTTVDEEEVDTRTLFFDRDGLWTGDLPGLTEALAGDGAPAASYLRRPLPAGTPESPLIDVVVQALQNLTAETADEPETFLAGPYRWQGDQAIDGRPTTVYRLREGRTVAVDDVDATLVQYRSPLRDGGPELTITLADHGDRRLALPTEEETAAAADHPGIAGTFGI
>NC_016943.1|WP_193345711.1|4851035_4851557_-|YqgE/AlgH-family-protein
MPVLTDPTFAGAVVFVLDHSDSGTVGVVLGRPSQVEIRDVLPGWCDLAVPPGVFHVGGPCETDTALCLATAPSGDPAAGLRPVAGDVHLVDLDGDPEALVGHLQGLRVFAGYAGWSAGQLAGEISEGAWACVPSRPGDVLSELPGPELWRRVMGRQTGRLAVLSSATADPTVN
>NC_016943.1|WP_014378689.1|4851866_4853138_+|MFS-transporter
MAEAGTTVRGLLVRPDFRRLLGTRLLSQFGDGVFQAALAGTVLFNPQRAADPVDVAAGFAVLLLPYSLVGPFAGVWLDRWSRRQVLLRANVLRAGLVAVVAALVLAGVQGPAFYAAGLAVFSVNRFILAALSAGLPHTTDEASLVSANAVSTTSGAVATVAGGGAALGLLQWTGSDDAGYAALALTAALPYLAAAVVVAGFSRGHLGPDHMARSARLSAGQVLAGMASGARHAWQHRPAAAALTAISLHRIWYGFLTLMALLLYRNTFVEASGPFPGGLVGLGLVVAAGAVGTLTAAAVTPAAVHRIGKAGWIGLLLATGGVAQVGLWLLLQPPAAVAAGFVLGFMGQGVKICVDTTLQECIDDDHRGRVFSVYDTLVNVGYVVALMAGAFVLPASGVSRPLLLVVGVGYVATAVLHGRMVRR
>NC_016943.1|WP_014378690.1|4853145_4854102_-|matrixin-family-metalloprotease
MTGVHPQEPGNDVPRMPTSPSGRTPQWVVAEATGTVTPVAAPLPRRRRRGRWAVPLVVAAVAAGLAFSDPPAWSWTPGAPAAVQAPPAATAPAKPTDRPTPAGATTPLGRPPLPPPAGGAYAYASLQDDGLTPVSYDPCREIHYVLHPEAAPPGTDGLVHDAVARITELTGLRFVFDGYTDEPLSAERPPFQPERYGDQWAPVLIGWQDEAQNPALVGDVVGEGGSTAVSLGDGPRVYVTGTVSLDAVQVPDILAEPDGAATLRSVVLHELAHLVGLSHVDDDRELMFPEARRGVTDFADGDRTGLATLGQGTCVPEL
>NC_016943.1|WP_041776908.1|4854175_4855624_-|CCA-tRNA-nucleotidyltransferase
MPPAVQETVRKLVEFSPVLTELGERFAAAGHQAHLVGGSVRDALLAAGAGGPGVPGDLDVTTDARPEQVLELLRGWARSTWNTGIAFGTVGADVRGTRVEITTFRADRYDRESRNPEVAWGDSLVDDLARRDFTVNAMAVSLGPDRTVTDPFGGLGDLLARRLRTPAAAVESFADDPLRMLRAVRFVAQLGLAPDDAVVSAMTSLGGDLARITPERVNAELSKTLLQDSPRAALELFVSTGLADVVLPELSALRMEIDEHHQHKDVYTHSLTVLDQAIALELADPEHESPDLVLRLAALLHDIGKPATRRHEPRGRVSFHHHEVVGAKLVRKRLTALRYPKDVVEAVARLTFLHLRFHGYGEGHWTDSAVRRYVTDAGNLLPRLHKLVRSDSTTRNKRRAAALSATYDALEQRIAELAEQEDLARVRPDLDGNAIMELLGLPPGPEVGAAWRFLKDLRLERGPLDRDEAEAALREWWAGRAG
>NC_016943.1|WP_014378692.1|4855793_4856270_+|NUDIX-hydrolase
MAGSGGRGRPGRRLRRVDETSAGGLVVADDGVTGPRAALIGRTDRRGRLLWSLPKGHIEAGETPEDTAVREVAEETGIIGEVVAPLGIIDFWFVAEGRRVHKTVHHFLLRAVGGALSDADVEVTEVAWVPLDELSTRLAYADERALVERAPGLLADSA
>NC_016943.1|WP_014378693.1|4856266_4858651_+|hypothetical-protein
MTRPAAARAGGRPAAASSARPGAARRAAAFAPLLAGALAVAGSGLAAVTVPATAAAAPGSTAAEQVTDADRQVRIDVARFEPRTVTPGSLITVTGTLTNTGTEPITDLAVRLQRGSVLTGRQDLAEAVGEPDPATTVEPPFVPLPGALAPGASMEFSYTLDSAELRLEQDGVYPALFNVNGTVGGDLERRVGELSTFLVQQPVVPSSRTTVAWLWPLSEPSHRNAAGAFVDDGLTEEISSGGRLDRALTVLERLPAGPPAGGTGEATRLPVTLALDPALVEELALMADGPYAVGGVAGAGTGTEEAQAFLERLRALTAGHPVVALPYGDVDADGLQSAGLGQVITRSLPGTPEGTAQARPAPWPDPAAGDGATPPTPVEPPTTGAGAQILADVLGVTPVTDLAWAADGSYELQTLDILRDGGIDRVVLGSGALSEGNSAVGLDGSDAVARTAVGEGDDALDVLVADPTLSAVVGAAGVTPGGPRIAEQRYLAELAALTLQGPPGSEQTVLVAPPRDLVAGLEGAGAMISDTVGLPWLRAGSVAGLGDVPPADAGSLAEPAEETGLGGVGMATLGEAVAAREDLAAAVAGDGDLALRPYDAGIARAASVLRRDAPEEFAEAAVDARATVAALREQVTVVAPVDGTYSLASSNAPLVLTVDNPLPFPVQVRLQVQTPGNRGLSVGDIGVQTLAPEQLTTLQVPTELRRSGGFSVTAQVTTPSGRPLGDPVEIQVKSTAYGPITLIITVGAASLLGLLFLRRLVHFVLRRRRGAAAGADASGPVAPGLAAPPARSPV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_016943_1	1.3\|1226555\|33\|NC_016943\|PILER-CR	1226555-1226587	33	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	144837-144869	6	0.818
NC_016943_1	1.3\|1226555\|33\|NC_016943\|PILER-CR	1226555-1226587	33	NZ_CP045548	Streptomyces sp. SYP-A7193 plasmid unnamed1, complete sequence	97995-98027	6	0.818
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	144837-144868	6	0.812
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NZ_CP045548	Streptomyces sp. SYP-A7193 plasmid unnamed1, complete sequence	97995-98026	6	0.812
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NZ_CP040763	Paracoccus sp. 2251 plasmid unnamed4, complete sequence	46408-46439	6	0.812
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NC_020062	Rhizobium tropici CIAT 899 plasmid pRtrCIAT899c, complete sequence	377958-377989	6	0.812
NC_016943_1	1.11\|1226678\|31\|NC_016943\|CRISPRCasFinder,CRT	1226678-1226708	31	NC_011887	Methylobacterium nodulans ORS 2060 plasmid pMNOD02, complete sequence	369550-369580	6	0.806
NC_016943_1	1.13\|1226799\|30\|NC_016943\|CRISPRCasFinder,CRT	1226799-1226828	30	NZ_LR594663	Variovorax sp. RA8 plasmid 2	335651-335680	6	0.8
NC_016943_1	1.1\|1226433\|33\|NC_016943\|PILER-CR	1226433-1226465	33	CP000663	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA02, complete sequence	196030-196062	7	0.788
NC_016943_1	1.1\|1226433\|33\|NC_016943\|PILER-CR	1226433-1226465	33	NZ_CP031752	Rhodobacter sphaeroides strain EBL0706 plasmid p.A, complete sequence	193466-193498	7	0.788
NC_016943_1	1.3\|1226555\|33\|NC_016943\|PILER-CR	1226555-1226587	33	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	493773-493805	7	0.788
NC_016943_1	1.7\|1226434\|32\|NC_016943\|CRISPRCasFinder,CRT	1226434-1226465	32	CP000663	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA02, complete sequence	196030-196061	7	0.781
NC_016943_1	1.7\|1226434\|32\|NC_016943\|CRISPRCasFinder,CRT	1226434-1226465	32	NZ_CP031752	Rhodobacter sphaeroides strain EBL0706 plasmid p.A, complete sequence	193466-193497	7	0.781
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	493774-493805	7	0.781
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NC_004808	Streptomyces rochei plasmid pSLA2-L DNA, complete sequence	57481-57512	7	0.781
NC_016943_1	1.13\|1226799\|30\|NC_016943\|CRISPRCasFinder,CRT	1226799-1226828	30	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	997084-997113	7	0.767
NC_016943_1	1.13\|1226799\|30\|NC_016943\|CRISPRCasFinder,CRT	1226799-1226828	30	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	2362722-2362751	7	0.767
NC_016943_1	1.3\|1226555\|33\|NC_016943\|PILER-CR	1226555-1226587	33	NC_004808	Streptomyces rochei plasmid pSLA2-L DNA, complete sequence	57480-57512	8	0.758
NC_016943_1	1.4\|1226616\|33\|NC_016943\|PILER-CR	1226616-1226648	33	MT498035	Gordonia Phage Barsten, complete genome	36423-36455	8	0.758
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	4602070-4602101	8	0.75
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NZ_CP014802	Salipiger profundus strain JLT2016 plasmid pTPRO6, complete sequence	6478-6509	8	0.75
NC_016943_1	1.10\|1226617\|32\|NC_016943\|CRISPRCasFinder,CRT	1226617-1226648	32	MT498035	Gordonia Phage Barsten, complete genome	36424-36455	8	0.75
NC_016943_1	1.10\|1226617\|32\|NC_016943\|CRISPRCasFinder,CRT	1226617-1226648	32	NZ_CP040995	Klebsiella pneumoniae strain FDAARGOS_775 plasmid unnamed3, complete sequence	102567-102598	8	0.75
NC_016943_1	1.13\|1226799\|30\|NC_016943\|CRISPRCasFinder,CRT	1226799-1226828	30	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	314817-314846	8	0.733
NC_016943_1	1.13\|1226799\|30\|NC_016943\|CRISPRCasFinder,CRT	1226799-1226828	30	MN908690	Microbacterium phage Hubbs, complete genome	10557-10586	8	0.733
NC_016943_1	1.13\|1226799\|30\|NC_016943\|CRISPRCasFinder,CRT	1226799-1226828	30	MN096374	Microbacterium phage Roman, complete genome	10404-10433	8	0.733
NC_016943_1	1.13\|1226799\|30\|NC_016943\|CRISPRCasFinder,CRT	1226799-1226828	30	MK937596	Microbacterium phage PhillyPhilly, complete genome	10409-10438	8	0.733
NC_016943_1	1.13\|1226799\|30\|NC_016943\|CRISPRCasFinder,CRT	1226799-1226828	30	MK919474	Microbacterium phage Lupine, complete genome	10229-10258	8	0.733
NC_016943_1	1.8\|1226495\|32\|NC_016943\|CRISPRCasFinder,CRT	1226495-1226526	32	NZ_HG938356	Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence	1042401-1042432	9	0.719
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NZ_CP053709	Acetobacteraceae bacterium strain PAMC 26569 plasmid unnamed1, complete sequence	374152-374183	9	0.719
NC_016943_1	1.10\|1226617\|32\|NC_016943\|CRISPRCasFinder,CRT	1226617-1226648	32	NZ_CP045204	Citrobacter sp. NMI7904_11 plasmid pCTEL-1, complete sequence	14701-14732	9	0.719
NC_016943_1	1.10\|1226617\|32\|NC_016943\|CRISPRCasFinder,CRT	1226617-1226648	32	NZ_CP013856	Pseudonocardia sp. HH130630-07 plasmid pLS2-2, complete sequence	67443-67474	9	0.719
NC_016943_1	1.12\|1226738\|32\|NC_016943\|CRISPRCasFinder,CRT	1226738-1226769	32	NC_016972	Streptomyces hygroscopicus subsp. jinggangensis 5008 plasmid pSHJG2, complete sequence	69028-69059	9	0.719
NC_016943_1	1.4\|1226616\|33\|NC_016943\|PILER-CR	1226616-1226648	33	NZ_CP045204	Citrobacter sp. NMI7904_11 plasmid pCTEL-1, complete sequence	14700-14732	10	0.697
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	1704247-1704278	10	0.688
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	MF415411	Klebsiella phage KPN U2874, complete genome	52164-52195	10	0.688
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	MF476924	Klebsiella phage YMC15/11/N53_KPN_BP, complete genome	52164-52195	10	0.688
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	MF415413	Klebsiella phage KPN N54, complete genome	52164-52195	10	0.688
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	MF415410	Klebsiella phage KPN N137, complete genome	52164-52195	10	0.688
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	MG835858	Klebsiella phage KPN N98, complete genome	52278-52309	10	0.688
NC_016943_1	1.13\|1226799\|30\|NC_016943\|CRISPRCasFinder,CRT	1226799-1226828	30	NZ_CP015882	Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence	1260642-1260671	10	0.667
NC_016943_1	1.13\|1226799\|30\|NC_016943\|CRISPRCasFinder,CRT	1226799-1226828	30	NZ_CP030264	Ensifer adhaerens strain Corn53 plasmid AB, complete sequence	1160003-1160032	10	0.667
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	MN106244	Klebsiella phage Soft, complete genome	11909-11940	11	0.656
NC_016943_1	1.9\|1226556\|32\|NC_016943\|CRISPRCasFinder,CRT	1226556-1226587	32	NC_048732	Klebsiella phage Seifer, complete genome	46650-46681	11	0.656

1. spacer 1.3|1226555|33|NC_016943|PILER-CR matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 6, identity: 0.818

cgccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
cccgagcgccccgtcctggggcagcgcgccgta	Protospacer
* * * ***** ******************* .

2. spacer 1.3|1226555|33|NC_016943|PILER-CR matches to NZ_CP045548 (Streptomyces sp. SYP-A7193 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.818

cgccaccg-cccggtcctggggcagcgcgccgag	CRISPR spacer
-gtcgccgccccgctcctggggcagcgcggcgac	Protospacer
 *.*.*** **** *************** ***

3. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 6, identity: 0.812

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
ccgagcgccccgtcctggggcagcgcgccgta	Protospacer
 * * ***** ******************* .

4. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP045548 (Streptomyces sp. SYP-A7193 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.812

gccaccg-cccggtcctggggcagcgcgccgag	CRISPR spacer
-tcgccgccccgctcctggggcagcgcggcgac	Protospacer
 .*.*** **** *************** ***

5. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP040763 (Paracoccus sp. 2251 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.812

gccaccgcccggtcctggggcagcgcgccgag---	CRISPR spacer
gccaccgcccggtccagcggcag---gccgggcgc	Protospacer
*************** * *****   ****.*

6. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NC_020062 (Rhizobium tropici CIAT 899 plasmid pRtrCIAT899c, complete sequence) position: , mismatch: 6, identity: 0.812

gccaccgcc-cggtcctggggcagcgcgccgag	CRISPR spacer
-gcattgccgcgatcctggagcagcgcgccgag	Protospacer
  **..*** **.******.*************

7. spacer 1.11|1226678|31|NC_016943|CRISPRCasFinder,CRT matches to NC_011887 (Methylobacterium nodulans ORS 2060 plasmid pMNOD02, complete sequence) position: , mismatch: 6, identity: 0.806

accccgaagcgcgggcaggacggctaccacg	CRISPR spacer
ccaccagagcgcgggcaggacggcttccacc	Protospacer
 * **..****************** ****

8. spacer 1.13|1226799|30|NC_016943|CRISPRCasFinder,CRT matches to NZ_LR594663 (Variovorax sp. RA8 plasmid 2) position: , mismatch: 6, identity: 0.8

ctcgggcgccgccgccccagaggacgacag	CRISPR spacer
attgaccgccgccgccgccgaggacgacag	Protospacer
 *.*. ********** * ***********

9. spacer 1.1|1226433|33|NC_016943|PILER-CR matches to CP000663 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA02, complete sequence) position: , mismatch: 7, identity: 0.788

cgtgtacatcggcccggacgagccccactgggc	CRISPR spacer
ccagtacatcggcctggtcgagccccagcgagc	Protospacer
*  ***********.** ********* .*.**

10. spacer 1.1|1226433|33|NC_016943|PILER-CR matches to NZ_CP031752 (Rhodobacter sphaeroides strain EBL0706 plasmid p.A, complete sequence) position: , mismatch: 7, identity: 0.788

cgtgtacatcggcccggacgagccccactgggc	CRISPR spacer
ccagtacatcggcctggtcgagccccagcgagc	Protospacer
*  ***********.** ********* .*.**

11. spacer 1.3|1226555|33|NC_016943|PILER-CR matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 7, identity: 0.788

cgccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
cccgagcgccccgtcccggggcagcgcgccgta	Protospacer
* * * ***** ****.************** .

12. spacer 1.7|1226434|32|NC_016943|CRISPRCasFinder,CRT matches to CP000663 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA02, complete sequence) position: , mismatch: 7, identity: 0.781

gtgtacatcggcccggacgagccccactgggc	CRISPR spacer
cagtacatcggcctggtcgagccccagcgagc	Protospacer
  ***********.** ********* .*.**

13. spacer 1.7|1226434|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP031752 (Rhodobacter sphaeroides strain EBL0706 plasmid p.A, complete sequence) position: , mismatch: 7, identity: 0.781

gtgtacatcggcccggacgagccccactgggc	CRISPR spacer
cagtacatcggcctggtcgagccccagcgagc	Protospacer
  ***********.** ********* .*.**

14. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 7, identity: 0.781

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
ccgagcgccccgtcccggggcagcgcgccgta	Protospacer
 * * ***** ****.************** .

15. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NC_004808 (Streptomyces rochei plasmid pSLA2-L DNA, complete sequence) position: , mismatch: 7, identity: 0.781

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
tcccgcgcccggtcctcgggcagcgcgacgga	Protospacer
 **  *********** ********** **..

16. spacer 1.13|1226799|30|NC_016943|CRISPRCasFinder,CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 7, identity: 0.767

ctcgggcgccgccgccccagaggacgacag	CRISPR spacer
gccctgcgccgccgccccggaggccgactg	Protospacer
 .*  *************.**** **** *

17. spacer 1.13|1226799|30|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 7, identity: 0.767

ctcgggcgccgccgccccagaggacgacag	CRISPR spacer
gccctgcgccgccgccccggaggccgactg	Protospacer
 .*  *************.**** **** *

18. spacer 1.3|1226555|33|NC_016943|PILER-CR matches to NC_004808 (Streptomyces rochei plasmid pSLA2-L DNA, complete sequence) position: , mismatch: 8, identity: 0.758

cgccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
ttcccgcgcccggtcctcgggcagcgcgacgga	Protospacer
. **  *********** ********** **..

19. spacer 1.4|1226616|33|NC_016943|PILER-CR matches to MT498035 (Gordonia Phage Barsten, complete genome) position: , mismatch: 8, identity: 0.758

cgcgcggctgaactcgtcagcggtgaccgcggt	CRISPR spacer
cgccgatctgaacgcgtcaccggtgaccgcgtc	Protospacer
***  . ****** ***** *********** .

20. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.75

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
agcgtctcgcggtcctcgggcagcacgccgag	Protospacer
. *..* * ******* *******.*******

21. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP014802 (Salipiger profundus strain JLT2016 plasmid pTPRO6, complete sequence) position: , mismatch: 8, identity: 0.75

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
agcaccgcccggtcgtagggcagcgtctcgac	Protospacer
. ************ *.********. .***

22. spacer 1.10|1226617|32|NC_016943|CRISPRCasFinder,CRT matches to MT498035 (Gordonia Phage Barsten, complete genome) position: , mismatch: 8, identity: 0.75

gcgcggctgaactcgtcagcggtgaccgcggt	CRISPR spacer
gccgatctgaacgcgtcaccggtgaccgcgtc	Protospacer
**  . ****** ***** *********** .

23. spacer 1.10|1226617|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP040995 (Klebsiella pneumoniae strain FDAARGOS_775 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.75

gcgcggctgaactcgtcagcggtga-ccgcggt	CRISPR spacer
tggcggcggaacacgtcagcggtgagttgctg-	Protospacer
  ***** **** ************ ..** *

24. spacer 1.13|1226799|30|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

ctcgggcgccgccgccccagaggacgacag	CRISPR spacer
taatggcgccgccgctccagcggacgaagg	Protospacer
.   ***********.**** ****** .*

25. spacer 1.13|1226799|30|NC_016943|CRISPRCasFinder,CRT matches to MN908690 (Microbacterium phage Hubbs, complete genome) position: , mismatch: 8, identity: 0.733

ctcgggcgccgccgccccagaggacgacag	CRISPR spacer
cggagtcgccgccgtcccagaggacgatct	Protospacer
*  .* ********.************.

26. spacer 1.13|1226799|30|NC_016943|CRISPRCasFinder,CRT matches to MN096374 (Microbacterium phage Roman, complete genome) position: , mismatch: 8, identity: 0.733

ctcgggcgccgccgccccagaggacgacag	CRISPR spacer
cggagtcgccgccgtcccagaggacgatct	Protospacer
*  .* ********.************.

27. spacer 1.13|1226799|30|NC_016943|CRISPRCasFinder,CRT matches to MK937596 (Microbacterium phage PhillyPhilly, complete genome) position: , mismatch: 8, identity: 0.733

ctcgggcgccgccgccccagaggacgacag	CRISPR spacer
cggagtcgccgccgtcccagaggacgatct	Protospacer
*  .* ********.************.

28. spacer 1.13|1226799|30|NC_016943|CRISPRCasFinder,CRT matches to MK919474 (Microbacterium phage Lupine, complete genome) position: , mismatch: 8, identity: 0.733

ctcgggcgccgccgccccagaggacgacag	CRISPR spacer
cggagtcgccgccgtcccagaggacgatct	Protospacer
*  .* ********.************.

29. spacer 1.8|1226495|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_HG938356 (Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence) position: , mismatch: 9, identity: 0.719

acgtcgtcgggcaacaaccactctggacggga	CRISPR spacer
gccgcatcgggcaacgaccattctggacgacg	Protospacer
.*  *.*********.****.********. .

30. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP053709 (Acetobacteraceae bacterium strain PAMC 26569 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
ccatccacccggtcgtggggcagcgcgtctcc	Protospacer
 *  **.******* ************.*

31. spacer 1.10|1226617|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP045204 (Citrobacter sp. NMI7904_11 plasmid pCTEL-1, complete sequence) position: , mismatch: 9, identity: 0.719

gcgcggctgaactcgtcagcggtgaccgcggt	CRISPR spacer
aaggtcctgaactcgtcagcgctgaacgcgcc	Protospacer
. *   *************** *** **** .

32. spacer 1.10|1226617|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP013856 (Pseudonocardia sp. HH130630-07 plasmid pLS2-2, complete sequence) position: , mismatch: 9, identity: 0.719

gcgcggctgaactcgtcagcggtgaccgcggt	CRISPR spacer
cagcggctgagcgcgtcagcggtgagtgacga	Protospacer
  ********.* ************ .*  *

33. spacer 1.12|1226738|32|NC_016943|CRISPRCasFinder,CRT matches to NC_016972 (Streptomyces hygroscopicus subsp. jinggangensis 5008 plasmid pSHJG2, complete sequence) position: , mismatch: 9, identity: 0.719

cgctcacatactgggccagcaggtcacgtgcc	CRISPR spacer
gggagccatcccgggccagcaggtcacgtacg	Protospacer
 *    *** *.*****************.*

34. spacer 1.4|1226616|33|NC_016943|PILER-CR matches to NZ_CP045204 (Citrobacter sp. NMI7904_11 plasmid pCTEL-1, complete sequence) position: , mismatch: 10, identity: 0.697

cgcgcggctgaactcgtcagcggtgaccgcggt	CRISPR spacer
gaaggtcctgaactcgtcagcgctgaacgcgcc	Protospacer
 . *   *************** *** **** .

35. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 10, identity: 0.688

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
gttggcgcacggtcttggggcagcgcgcgcct	Protospacer
*... *** *****.*************

36. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to MF415411 (Klebsiella phage KPN U2874, complete genome) position: , mismatch: 10, identity: 0.688

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
cggcccgcccagtcctggcgcagcgcgttgtc	Protospacer
    ******.******* ********..*

37. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to MF476924 (Klebsiella phage YMC15/11/N53_KPN_BP, complete genome) position: , mismatch: 10, identity: 0.688

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
cggcccgcccagtcctggcgcagcgcgttgtc	Protospacer
    ******.******* ********..*

38. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to MF415413 (Klebsiella phage KPN N54, complete genome) position: , mismatch: 10, identity: 0.688

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
cggcccgcccagtcctggcgcagcgcgttgtc	Protospacer
    ******.******* ********..*

39. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to MF415410 (Klebsiella phage KPN N137, complete genome) position: , mismatch: 10, identity: 0.688

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
cggcccgcccagtcctggcgcagcgcgttgtc	Protospacer
    ******.******* ********..*

40. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to MG835858 (Klebsiella phage KPN N98, complete genome) position: , mismatch: 10, identity: 0.688

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
cggcccgcccagtcctggcgcagcgcgttgtc	Protospacer
    ******.******* ********..*

41. spacer 1.13|1226799|30|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP015882 (Ensifer adhaerens strain Casida A plasmid pCasidaAB, complete sequence) position: , mismatch: 10, identity: 0.667

ctcgggcgccgccgccccagaggacgacag	CRISPR spacer
ggaacacgccgccgccccacaggacgagcc	Protospacer
   . .************* *******

42. spacer 1.13|1226799|30|NC_016943|CRISPRCasFinder,CRT matches to NZ_CP030264 (Ensifer adhaerens strain Corn53 plasmid AB, complete sequence) position: , mismatch: 10, identity: 0.667

ctcgggcgccgccgccccagaggacgacag	CRISPR spacer
ggaacacgccgccgccccacaggacgagcc	Protospacer
   . .************* *******

43. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to MN106244 (Klebsiella phage Soft, complete genome) position: , mismatch: 11, identity: 0.656

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
cggcccgcccagtcctggcgcagcgcgttatc	Protospacer
    ******.******* ********...

44. spacer 1.9|1226556|32|NC_016943|CRISPRCasFinder,CRT matches to NC_048732 (Klebsiella phage Seifer, complete genome) position: , mismatch: 11, identity: 0.656

gccaccgcccggtcctggggcagcgcgccgag	CRISPR spacer
ctgcccgcccagtcctggcgcagcgcgttatc	Protospacer
 .  ******.******* ********...

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1404212 : 1472644

Mycobacterium_phage(20.0%)

integrase,transposase,protease

attL 1403364:1403380|attR 1456594:1456610

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1403364:1403380	attL	NA	NA	NA	NA
WP_014375299.1\|1404212_1405346_-\|integrase	tyrosine-type recombinase/integrase	A0A249XVB5	Mycobacterium_phage	1.0e-46	35.3
WP_051004873.1\|1405657_1405879_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014375301.1\|1406429_1406882_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_166486490.1\|1407281_1407689_+	hypothetical protein	NA	NA	NA	NA
WP_014375304.1\|1407682_1408582_+	hypothetical protein	NA	NA	NA	NA
WP_014375305.1\|1408578_1409262_+	flagellar protein FlgA	NA	NA	NA	NA
WP_014375306.1\|1409276_1410077_+	hypothetical protein	NA	NA	NA	NA
WP_041776207.1\|1410093_1411488_+	Flp pilus assembly complex ATPase component TadA	NA	NA	NA	NA
WP_014375308.1\|1411484_1412396_+	type II secretion system F family protein	NA	NA	NA	NA
WP_014375309.1\|1412392_1413307_+	type II secretion system F family protein	NA	NA	NA	NA
WP_014375310.1\|1413337_1413535_+	hypothetical protein	NA	NA	NA	NA
WP_014375311.1\|1413663_1414008_+	pilus assembly protein	NA	NA	NA	NA
WP_014375312.1\|1414004_1414430_+	pilus assembly protein	NA	NA	NA	NA
WP_014375313.1\|1414426_1414873_+	hypothetical protein	NA	NA	NA	NA
WP_014375314.1\|1414869_1418106_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_014375316.1\|1418744_1419002_+	hypothetical protein	NA	NA	NA	NA
WP_014375317.1\|1419303_1420122_+	hypothetical protein	NA	NA	NA	NA
WP_166486716.1\|1420151_1420502_+	hypothetical protein	NA	NA	NA	NA
WP_014375319.1\|1420501_1421308_+	hypothetical protein	NA	NA	NA	NA
WP_051004875.1\|1421300_1422929_+	hypothetical protein	NA	NA	NA	NA
WP_014375321.1\|1422925_1424440_+	hypothetical protein	NA	NA	NA	NA
WP_014375322.1\|1424436_1425945_+	ATP-binding protein	NA	NA	NA	NA
WP_014375323.1\|1425941_1427111_+	M23 family metallopeptidase	A0A075BS18	Microcystis_phage	5.3e-19	42.4
WP_014375324.1\|1427176_1429090_+	TraM recognition domain-containing protein	NA	NA	NA	NA
WP_166486491.1\|1429104_1429665_+	hypothetical protein	NA	NA	NA	NA
WP_014375326.1\|1429661_1430141_+	hypothetical protein	NA	NA	NA	NA
WP_014375327.1\|1430250_1430547_+	hypothetical protein	NA	NA	NA	NA
WP_166486492.1\|1430570_1431884_+	hypothetical protein	NA	NA	NA	NA
WP_041776211.1\|1432947_1434333_-	hypothetical protein	NA	NA	NA	NA
WP_014375332.1\|1435089_1435611_-	hypothetical protein	NA	NA	NA	NA
WP_014375334.1\|1436022_1437024_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	3.9e-10	28.7
WP_041775647.1\|1437020_1438796_-	hypothetical protein	NA	NA	NA	NA
WP_014374930.1\|1438961_1440269_+\|transposase	IS256-like element ISBsa1 family transposase	NA	NA	NA	NA
WP_166486418.1\|1440347_1440803_+	hypothetical protein	NA	NA	NA	NA
WP_041775648.1\|1440959_1441469_+	hypothetical protein	NA	NA	NA	NA
WP_166486493.1\|1441609_1442539_-	hypothetical protein	NA	NA	NA	NA
WP_041775650.1\|1442884_1448380_-	relaxase domain-containing protein	NA	NA	NA	NA
WP_041776212.1\|1448794_1449517_+\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_014375340.1\|1449513_1451559_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_041776213.1\|1451576_1452623_+	TniB family NTP-binding protein	NA	NA	NA	NA
WP_014375342.1\|1452622_1453816_+	TniQ family protein	NA	NA	NA	NA
WP_014375345.1\|1454644_1456444_+	hypothetical protein	NA	NA	NA	NA
WP_051004876.1\|1456458_1458804_+	sensor histidine kinase	NA	NA	NA	NA
1456594:1456610	attR	NA	NA	NA	NA
WP_014375347.1\|1458800_1459937_+	hypothetical protein	NA	NA	NA	NA
WP_166486494.1\|1459998_1460544_+	hypothetical protein	NA	NA	NA	NA
WP_014375349.1\|1460719_1461799_+	DUF4365 domain-containing protein	NA	NA	NA	NA
WP_014375350.1\|1462106_1466870_+	DEAD/DEAH box helicase	A0A1V0SHP4	Klosneuvirus	5.7e-27	23.4
WP_014375351.1\|1467396_1468044_+	histidine kinase	NA	NA	NA	NA
WP_166486495.1\|1468040_1470053_+	DUF2306 domain-containing protein	NA	NA	NA	NA
WP_014375353.1\|1470308_1471757_+	trigger factor	NA	NA	NA	NA
WP_051005141.1\|1472044_1472644_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	3.0e-42	49.7

DBSCAN-SWA_2

1717240 : 1783277

Mycobacterium_phage(50.0%)

integrase,transposase

attL 1715491:1715508|attR 1789049:1789066

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1715491:1715508	attL	NA	NA	NA	NA
WP_014375595.1\|1717240_1718548_+\|transposase	ISL3 family transposase	A0A2H4PDF8	Mycobacterium_phage	5.1e-196	76.8
WP_014375596.1\|1718928_1719159_+	hypothetical protein	NA	NA	NA	NA
WP_166486724.1\|1719271_1720093_-	diguanylate cyclase	NA	NA	NA	NA
WP_014375599.1\|1720361_1720601_-	hypothetical protein	NA	NA	NA	NA
WP_014375602.1\|1721704_1725322_+	relaxase domain-containing protein	NA	NA	NA	NA
WP_014375603.1\|1725553_1726660_+\|integrase	site-specific integrase	A0A0E3XBN7	Gordonia_phage	1.4e-53	38.7
WP_014375604.1\|1727564_1728518_+	hypothetical protein	NA	NA	NA	NA
WP_166486725.1\|1728667_1729306_-	peptidase	NA	NA	NA	NA
WP_166486726.1\|1729777_1730185_+	hypothetical protein	NA	NA	NA	NA
WP_014375607.1\|1730172_1731144_+	hypothetical protein	NA	NA	NA	NA
WP_166486510.1\|1731161_1731875_+	hypothetical protein	NA	NA	NA	NA
WP_014375610.1\|1731879_1732662_+	hypothetical protein	NA	NA	NA	NA
WP_014375611.1\|1732658_1734197_+	CpaF family protein	NA	NA	NA	NA
WP_014375612.1\|1734193_1735060_+	pilus assembly protein TadB	NA	NA	NA	NA
WP_014375613.1\|1735056_1735956_+	hypothetical protein	NA	NA	NA	NA
WP_014375614.1\|1735982_1736219_+	hypothetical protein	NA	NA	NA	NA
WP_014375615.1\|1736235_1736706_+	pilus assembly protein	NA	NA	NA	NA
WP_014375616.1\|1736702_1737167_+	hypothetical protein	NA	NA	NA	NA
WP_166486511.1\|1737163_1737589_+	hypothetical protein	NA	NA	NA	NA
WP_166486727.1\|1737669_1740957_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_014375619.1\|1741371_1742448_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_014375620.1\|1742444_1742753_-	hypothetical protein	NA	NA	NA	NA
WP_051004909.1\|1742930_1743209_+	multiubiquitin domain-containing protein	NA	NA	NA	NA
WP_014375622.1\|1743183_1744416_+	ThiF family adenylyltransferase	NA	NA	NA	NA
WP_014375623.1\|1744405_1744810_+	hypothetical protein	NA	NA	NA	NA
WP_014375625.1\|1745499_1747788_-	AAA family ATPase	NA	NA	NA	NA
WP_014375626.1\|1748183_1748735_+	hypothetical protein	NA	NA	NA	NA
WP_014375628.1\|1749126_1749720_+	hypothetical protein	NA	NA	NA	NA
WP_166486512.1\|1750070_1750847_+	hypothetical protein	NA	NA	NA	NA
WP_051004913.1\|1751299_1751956_+	hypothetical protein	NA	NA	NA	NA
WP_014375631.1\|1751964_1752327_+	hypothetical protein	NA	NA	NA	NA
WP_014375632.1\|1752326_1753133_+	hypothetical protein	NA	NA	NA	NA
WP_166486728.1\|1753173_1754742_+	hypothetical protein	NA	NA	NA	NA
WP_014375634.1\|1754738_1756253_+	hypothetical protein	NA	NA	NA	NA
WP_014375635.1\|1756249_1757758_+	ATP-binding protein	NA	NA	NA	NA
WP_014375636.1\|1757754_1758921_+	M23 family metallopeptidase	A0A2D0ZM66	Rhodococcus_phage	2.8e-28	34.5
WP_014375637.1\|1759028_1759595_+	hypothetical protein	NA	NA	NA	NA
WP_014375638.1\|1759591_1759900_+	hypothetical protein	NA	NA	NA	NA
WP_014375639.1\|1759899_1761192_+	hypothetical protein	NA	NA	NA	NA
WP_014375640.1\|1761204_1762725_+	TraM recognition domain-containing protein	NA	NA	NA	NA
WP_166486513.1\|1762721_1763201_+	hypothetical protein	NA	NA	NA	NA
WP_014375642.1\|1763385_1764033_+	Abi family protein	NA	NA	NA	NA
WP_166486514.1\|1764227_1764956_+	hypothetical protein	NA	NA	NA	NA
WP_041775678.1\|1765057_1766140_-	hypothetical protein	NA	NA	NA	NA
WP_166486729.1\|1766398_1772011_-	relaxase domain-containing protein	V5UQN3	Mycobacterium_phage	6.9e-32	24.9
WP_166486710.1\|1772186_1773485_-	hypothetical protein	NA	NA	NA	NA
WP_014375253.1\|1773637_1773982_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_166486711.1\|1773978_1775055_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_041776212.1\|1775530_1776253_+\|transposase	TnsA-like heteromeric transposase endonuclease subunit	NA	NA	NA	NA
WP_014375340.1\|1776249_1778295_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_041776213.1\|1778312_1779359_+	TniB family NTP-binding protein	NA	NA	NA	NA
WP_014375342.1\|1779358_1780552_+	TniQ family protein	NA	NA	NA	NA
WP_166486515.1\|1780738_1781134_+	hypothetical protein	NA	NA	NA	NA
WP_051004915.1\|1781437_1781773_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014375649.1\|1782227_1783277_-\|transposase	IS110 family transposase	NA	NA	NA	NA
1789049:1789066	attR	NA	NA	NA	NA

DBSCAN-SWA_3

4226714 : 4267817

Bacillus_virus(50.0%)

integrase,transposase,protease

attL 4235718:4235737|attR 4276913:4276932

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014378067.1\|4226714_4228376_-\|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_166486602.1\|4228441_4228693_-	hypothetical protein	NA	NA	NA	NA
WP_014378068.1\|4228783_4228993_-	biotin/lipoyl-binding carrier protein	NA	NA	NA	NA
WP_014378069.1\|4229004_4230348_-	biotin carboxylase	NA	NA	NA	NA
WP_014378070.1\|4230426_4231890_-	CoA-binding protein	NA	NA	NA	NA
WP_014378071.1\|4231886_4232651_-	acetate--CoA ligase family protein	NA	NA	NA	NA
WP_041776776.1\|4232775_4234311_-	methylmalonyl-CoA carboxyltransferase	NA	NA	NA	NA
WP_014378073.1\|4234468_4235764_-	TRAP transporter large permease	NA	NA	NA	NA
4235718:4235737	attL	NA	NA	NA	NA
WP_166486603.1\|4235815_4236289_-	TRAP transporter small permease subunit	NA	NA	NA	NA
WP_014378075.1\|4236500_4237592_-	TRAP transporter substrate-binding protein DctP	NA	NA	NA	NA
WP_014378076.1\|4237883_4238843_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_014378077.1\|4239154_4239769_+	CoA pyrophosphatase	NA	NA	NA	NA
WP_014378080.1\|4240570_4241056_+\|transposase	transposase	NA	NA	NA	NA
WP_014378081.1\|4241028_4241523_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_166486604.1\|4241519_4241942_+	hypothetical protein	NA	NA	NA	NA
WP_014378083.1\|4241938_4242688_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	4.7e-53	48.4
WP_014378085.1\|4243202_4244087_-	hypothetical protein	NA	NA	NA	NA
WP_051005083.1\|4244086_4244869_-	ABC transporter permease	NA	NA	NA	NA
WP_014378088.1\|4245249_4245843_-	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	1.5e-17	34.2
WP_014378089.1\|4245839_4246661_-	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	4.9e-19	32.0
WP_014378090.1\|4246675_4248208_-	methylmalonyl-CoA carboxyltransferase	NA	NA	NA	NA
WP_014378091.1\|4248311_4249061_-	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_014378092.1\|4249094_4251329_-	acetate--CoA ligase family protein	NA	NA	NA	NA
WP_014378093.1\|4251377_4252226_-	ABC transporter permease	NA	NA	NA	NA
WP_014378094.1\|4252222_4253059_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.0e-28	36.2
WP_166486605.1\|4253063_4254071_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_166486606.1\|4254256_4255342_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_193345667.1\|4255457_4256513_+	hypothetical protein	NA	NA	NA	NA
WP_014378098.1\|4257001_4257247_+	hypothetical protein	NA	NA	NA	NA
WP_166486710.1\|4257764_4259063_-	hypothetical protein	NA	NA	NA	NA
WP_014375253.1\|4259215_4259560_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_166486711.1\|4259556_4260633_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_014378100.1\|4261507_4261939_-	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_014378101.1\|4261938_4262199_-	type II toxin-antitoxin system prevent-host-death family antitoxin	NA	NA	NA	NA
WP_014378102.1\|4262320_4263688_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_166486607.1\|4264111_4264984_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_014378105.1\|4264953_4266120_-	mandelate racemase/muconate lactonizing enzyme family protein	NA	NA	NA	NA
WP_014378106.1\|4266213_4266918_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_014378107.1\|4266938_4267817_-\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
4276913:4276932	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_016943

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection