CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_018526	Streptococcus suis S735, complete sequence	5 crisprs	PrimPol,DinG,csa3,cas3,DEDDh	0	0	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_018526_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018526_1

16638-16768

Unclear

Consensus_repeat	Method
GAGTTGTCTCTTGAGGGACTAGTTAACAGAGGAACGAAAAAA	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NC_018526_1

>merge|NC_018526|1|16638-16768|CRISPRCasFinder
GAGTTGTCTCTTGAGGGACTAGTTAACAGAGGAACGAAAAAAGTTTCGAAAAAGTGTTGACAAGACCATCAGAAGATGATAGACTAATGGAGTTGTCTCTTGAGGGACTGGTTAACAGAGGAACGAAAAAA

>NC_018526|1|1|16638-16768|CRISPRCasFinder
GAGTTGTCTCTTGAGGGACTAGTTAACAGAGGAACGAAAAAA	GTTTCGAAAAAGTGTTGACAAGACCATCAGAAGATGATAGACTAATG
GAGTTGTCTCTTGAGGGACTGGTTAACAGAGGAACGAAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_018526.1\|WP_011921646.1\|30711_31419_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|181800
NC_018526.1\|WP_011921636.1\|11815_13084_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|238950
NC_018526.1\|WP_011921644.1\|29345_30353_+\|phosphate-acyltransferase-PlsX	unknown	unknown	gnl\|CDD\|235414
NC_018526.1\|WP_012774879.1\|4398_5514_+\|redox-regulated-ATPase-YchF	unknown	unknown	gnl\|CDD\|236583
NC_018526.1\|WP_014917168.1\|26346_27315_+\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|167353
NC_018526.1\|WP_002935339.1\|24387_24903_+\|rod-shape-determining-protein-MreD	unknown	unknown	gnl\|CDD\|282013
NC_018526.1\|WP_011922532.1\|27401_28580_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235985
NC_018526.1\|WP_002935335.1\|28566_29349_+\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|273175
NC_018526.1\|WP_012775463.1\|13091_13634_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NC_018526.1\|WP_011921638.1\|13655_15629_+\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NC_018526.1\|WP_011921633.1\|5671_6241_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NC_018526.1\|WP_012774880.1\|24987_26244_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226400
NC_018526.1\|WP_004194327.1\|10043_10412_+\|septum-formation-initiator-family-protein	unknown	unknown	gnl\|CDD\|225471
NC_018526.1\|WP_011921639.1\|15966_16437_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_018526.1\|WP_012775464.1\|23561_24398_+\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560
NC_018526.1\|WP_012774881.1\|31431_35151_+\|phosphoribosylformylglycinamidine-synthase	unknown	unknown	gnl\|CDD\|130916
NC_018526.1\|WP_011921634.1\|6240_9735_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NC_018526.1\|WP_011921645.1\|30345_30594_+\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|183533
NC_018526.1\|WP_004194330.1\|9784_10057_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NC_018526.1\|WP_011921635.1\|10534_11815_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|379138

Protein	Function_ID	Function_description	E-value
NC_018526.1\|WP_011921646.1\|30711_31419_+\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|181800	PRK09362, PRK09362, phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed.	4.61705e-143
NC_018526.1\|WP_011921636.1\|11815_13084_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	6.49313e-74
NC_018526.1\|WP_011921644.1\|29345_30353_+\|phosphate-acyltransferase-PlsX	gnl\|CDD\|235414	PRK05331, PRK05331, phosphate acyltransferase PlsX.	8.90536e-173
NC_018526.1\|WP_012774879.1\|4398_5514_+\|redox-regulated-ATPase-YchF	gnl\|CDD\|236583	PRK09601, PRK09601, redox-regulated ATPase YchF.	0
NC_018526.1\|WP_014917168.1\|26346_27315_+\|ribose-phosphate-diphosphokinase	gnl\|CDD\|167353	PRK02269, PRK02269, ribose-phosphate diphosphokinase.	0
NC_018526.1\|WP_002935339.1\|24387_24903_+\|rod-shape-determining-protein-MreD	gnl\|CDD\|282013	pfam04093, MreD, rod shape-determining protein MreD. MreD (murein formation D) is involved in the rod shape determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped.	0.00116629
NC_018526.1\|WP_011922532.1\|27401_28580_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235985	PRK07309, PRK07309, pyridoxal phosphate-dependent aminotransferase.	0
NC_018526.1\|WP_002935335.1\|28566_29349_+\|DNA-repair-protein-RecO	gnl\|CDD\|273175	TIGR00613, DNA_repair_protein_RecO, DNA repair protein RecO. All proteins in this family for which functions are known are DNA binding proteins that are involved in the initiation of recombination or recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	3.30367e-78
NC_018526.1\|WP_012775463.1\|13091_13634_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	2.51562e-92
NC_018526.1\|WP_011921638.1\|13655_15629_+\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_018526.1\|WP_011921633.1\|5671_6241_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	6.27614e-97
NC_018526.1\|WP_012774880.1\|24987_26244_+\|CHAP-domain-containing-protein	gnl\|CDD\|226400	COG3883, COG3883, Uncharacterized protein conserved in bacteria [Function unknown].	3.21323e-51
NC_018526.1\|WP_004194327.1\|10043_10412_+\|septum-formation-initiator-family-protein	gnl\|CDD\|225471	COG2919, COG2919, Septum formation initiator [Cell division and chromosome partitioning].	3.84819e-14
NC_018526.1\|WP_011921639.1\|15966_16437_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	0.00468367
NC_018526.1\|WP_012775464.1\|23561_24398_+\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	1.15531e-53
NC_018526.1\|WP_012774881.1\|31431_35151_+\|phosphoribosylformylglycinamidine-synthase	gnl\|CDD\|130916	TIGR01857, FGAM-synthase, phosphoribosylformylglycinamidine synthase, clade II. This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis].	0
NC_018526.1\|WP_011921634.1\|6240_9735_+\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NC_018526.1\|WP_011921645.1\|30345_30594_+\|acyl-carrier-protein	gnl\|CDD\|183533	PRK12449, PRK12449, acyl carrier protein; Provisional.	1.19684e-17
NC_018526.1\|WP_004194330.1\|9784_10057_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	4.26063e-31
NC_018526.1\|WP_011921635.1\|10534_11815_+\|serine-hydrolase	gnl\|CDD\|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.88913e-42

>NC_018526.1|WP_011921639.1|15966_16437_+|sigma-70-family-RNA-polymerase-sigma-factor
MEFEKVYASVKGIVNKARKEFYIKLWDRDDWEQEGMMTLFELLEAQPWLVDEQVQLYCYFKVKFRNRIKDRIRKQESQKRKFDRMPHEDIYELSHAIQSPGLINDELLMLRGALRDYRKNLSNDQLDKYEKLISGQCFNGRREMIRDLQIHLKDFR
>NC_018526.1|WP_011921638.1|13655_15629_+|ATP-dependent-zinc-metalloprotease-FtsH
MNNQPNKGFIKNPFLIILVIATIVTAFQFFNAGQQVATQEISYSQVVTELKNNNVSEITYQPNSSVIEITGKYKTEQEAKDELASSIKLFQVSSKVKYKNFKSLILPSETNLSELQALANENGVKVAIKPESSNGLWLNIIFNLLPLVIAGVFFMMMMNQGGGGARGAMNFGRNKAKALEQSNIKVRFSDVAGAEEEKQELVEVVEFLKDPKRFTKLGARIPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAKKAAPAIIFIDEIDAVGRQRGVGMGGGNDEREQTLNQLLIEMDGFEGNEGIIVIAATNRSDVLDPALLRPGRFDRKVLVGRPDVKGREAILKVHAKNKPLAADVDLKLVAQQTPGFVGADLENVLNEAALVAARRNKTVIDASDIDEAEDRVIAGPSKKDRQVSAKEREIVAYHEAGHTIVGLVLSNAREVHKVTIVPRGRAGGYMIALPKEDQMLLSKEDMKEQLAGLMGGRVAEEIIFNTQTTGASNDFEQATQMARAMVAEYGMSDKMGPMQYEGSHAMFGGQTTQKHISEQTAYELDNEVRDLLNEARNKAAEIIQSNRETHKLIAEALLKYETLDSVQIKSLYETGKMPENIERDDEDVHPLSYEEVKEKINTKE
>NC_018526.1|WP_012775463.1|13091_13634_+|hypoxanthine-phosphoribosyltransferase
MLDKDIKKILVSEEEIVAKCKELGQILATDYADKNPILVGILKGSIPFMAELMKHIDAHVETDYMVVSSYHGGTESCGTVKIIKDLDNSVAGRHIIFVEDIIDTGRTLKELKELFALRQAASIKIATLLDKPEGRVVEIEPDYTCFTIPNEFVVGFGLDYDENYRNLPYVGVLKEEVYTK
>NC_018526.1|WP_011921636.1|11815_13084_+|tRNA-lysidine(34)-synthetase-TilS
MKDRFLKVTLDGHFFDKHKKVLVAVSGGLDSMNLFHLLYECKQVLGIELGIAHINHGQREESVIEEKYLRQLAEESNVPFYLSYFEGVFSEEAARKWRYGFFATIMEKEGYTALVTAHHADDQAETVFMRLIRGGRLRHLSAIQPTQPFATGELIRPLLSFKKADFEKLFHFEDCSNADFKYFRNRVRNDYLPKLKQENPKIELTLNNLAVDTNNLFQALRDLTQDLSVTDVMSFQQQTPAVQSYLLEEYLEKFPDLQLSRPQFNEVLHILRSKANYYHLLKNDYMLEKDYHRFQIYKIGPETDSQPEKIMIESEGIFSYGSYIFSLNHPLEEADSILYFPTENPIVVRRRQAGDTILINGVNKKLRRWFIDNKISQKVRQNALIIEQNGEIYGITNLVSSDLSKSVKNDIIKATLYIKMKE
>NC_018526.1|WP_011921635.1|10534_11815_+|serine-hydrolase
MQKKLLVWLLPVLFGWQVVDSTEIPFELTAQEEYELTHTIYDQYFQTIPQNPNVFQTENLYSDEELTIAGGQLQPNQHFSITDVLVNSKKELVFQIDDKGYILASRHLLFDDVIVTETTVEQTYWTKKGFTLLTSPIANEATEIKNDLQPYQAVMVSKIVTTSLGDFAYVTDKGWIAVNNLSKTDNRVEAVQELLTNKYSKDTIGIYVKQLSTGQTAGVNQEKLFYSASIAKLPILYYVQEQLNAGYIDLTTKVKYTAESISFPGAYVAGGSGSLSKTPDNKDYSVEELINKTAKESDNVASNLLSYYVANKFDSNFYQVITAKTGSEWSMVTRETSAEIAGKMMEALYIQNGYVLESLLSTQFDNQRISKDISVPVAHKIGDADDVKHDVAIVYAGSPFVLSIFTDKSNYDEITQIANDIYRILK
>NC_018526.1|WP_004194327.1|10043_10412_+|septum-formation-initiator-family-protein
MKKSKILQLNNAFIQSERKKTQHQLAERQQKNRFMGAILILVIFLFMLPAYNLVGTYTNIQQQEKKLAELEKNYEELTKEQKQEAEMVAKLKNEEYAAKYVRAKYQYSKEGEFVYNIPGLPK
>NC_018526.1|WP_004194330.1|9784_10057_+|RNA-binding-S4-domain-containing-protein
MRLDKYLKVSRIIKRRTVAKEVADKGRIKVNGILAKSSTDLKVNDQVEIQFGNKLLTVKVLEMKDSTKKEDALKMYEIISEKRIEKDEEI
>NC_018526.1|WP_011921634.1|6240_9735_+|transcription-repair-coupling-factor
MNILDLLHKNKQINQWQSGLNQSTRQLLLGLSGTSKSLIMATAYDCLAEKIMIVTATQNDAEKLVADLTAIIGSENVYNFFTDDSPIAEFVFASKERTQSRIDSLNFLTDSTSSGILVASIVACRVLLPSPETYKGSKIQLEVGQEIEVDKLVKNLVNIGYKKVSRVLTQGEFSQRGDILDIFDMQSETPYRIEFFGDEIDGIRIFDVDSQKSLENLDEISISPASDIILSSEDYSRASQYIQTAIEQSTLEEQQSYLREVLADMQTEYRHPDLRKFLSCIYEQSWTLLDYLPKSSPLFLDDFHKIADKQAQFEKEIADLLTDDLQKGKTVSSLKYFASTYAELRKYKPATFFSSFQKGLGNVKFDALYQFTQHPMQEFFHQIPLLKDELTRYAKSNNTVVIQASSDVSLQTLQKNLQEYDIHLPVHAADKLVEGQQQVTIGQLASGFHLMDEKLVFITEKEIFNKKMKRKTRRTNISNAERIKDYSELAVGDYVVHHVHGIGQYLGIETIEISGIHRDYLTVQYQNSDRISIPVEQIDLLSKYLASDGKAPKVNKLNDGRFQRTKQKVQKQVEDIADDLIKLYAERSQLKGFAFSPDDENQVEFDNYFTHVETDDQLRSIDEIKKDMEKDSPMDRLLVGDVGFGKTEVAMRAAFKAVNDGKQVAILVPTTVLAQQHYANFQERFAEFPVNVDVMSRFKTKAEQEKTLEKLKKGQVDILIGTHRLLSKDVVFADLGLLVIDEEQRFGVKHKERLKELKKKIDVLTLTATPIPRTLQMSMLGIRDLSVIETPPTNRYPVQTYVMETNPSVIRDAMLREIDRGGQVYYLYNKVDTIEQKVSELKELVPEATIGYVHGQMSEIQLENTLYAFVEGEYDILVTTTIIETGVDIPNANTLFIENADHMGLSTLYQLRGRVGRSSRIAYAYLMYRPDKSLTEVAEKRLEAIKGFTELGSGFKIAMQDLSIRGAGNILGAAQSGFIDSVGYEMYSQLLEQAILEKQGKATQRQKSNSEVNLQIDAYLPSDYIGDQRQKIEIYKRIKNIDSRVNYQELQEELIDRFGEYPDVVAYLLEIGLLKSFLDQVFCHTVLRRQHQVTVTFEPMAGQIFLTQDYFEALSVTNLKAQITENKGKLAVVFNIQQKKEYEILEELISFAEKLKEIKARKAE
>NC_018526.1|WP_011921633.1|5671_6241_+|aminoacyl-tRNA-hydrolase
MTRLIIGLGNPGDRYFETKHNVGFMLLDKIAKRENVTFNHDKIFQADIATTFIDGEKIYLVKPTTFMNESGKAVHALMTYYGLDATDILVAYDDLDMAVGKIRFRQKGSAGGHNGIKSIVKHIGTQEFDRIKIGIGRPKGKMSVVNHVLSGFDIEDRIEIDLALDKLDKAVNVYLEEDDFDTVMRKFNG
>NC_018526.1|WP_012774879.1|4398_5514_+|redox-regulated-ATPase-YchF
MSLTAGIVGLPNVGKSTLFNAITKAGAEAANYPFATIDPNVGMVEVPDERLQKLTELIIPKKTVPTTFEFTDIAGIVKGASKGEGLGNKFLANIREVDAIVHVVRAFDDENVMREQGREDAFVDPIADIDTINLELILADLESINKRYARVEKMARTQKDKDSVAEFAVLEKIKPVLEDGKSARTVEFTDEEQKIVKQLFLLTTKPVLYVANVDEDKVADPEAISYVQQIRDFAATENAEVVVISARAEEEISELDDEDKGEFLEALGLTESGVDKLTRAAYHLLGLGTYFTAGEKEVRAWTFKRGMKAPQCAGIIHSDFEKGFIRAVTMSYDDLMTYGSEKAVKEAGRLREEGKEYVVQDGDIMEFRFNV
>NC_018526.1|WP_012775464.1|23561_24398_+|rod-shape-determining-protein-MreC
MNKFSKLVVVVSIFLLLSFSLLFVTFSKGLQVPYLNNIVRVVVTPIQSVISVPTRFFSEQKDVLTDLMNAYEENKQLKETIMSLEGMAAENTSLKEENASLRSSLGVVSDFPEKQLIPGSVLVRTPSSWSEHISINIGETSGVTYNALVVANGGLVGIVSSLSSDSAVVTLFTNSDEFTKLPVKISVDSKEIYGILSGYDADTNSFIINQLNSADEIAVGSNVVTSDLAGATPANVQIGKVLSVKSNSNSLNREVYVEPTASFSNIYSVLVVGQTNAQ
>NC_018526.1|WP_002935339.1|24387_24903_+|rod-shape-determining-protein-MreD
MRNKMIEIFMFPILFFILLLDGQISTLVTNWSVGLFTISSHLVLMLAIFYANYVSLGFSLFIFTLLGLVYDISYLNLIGIATTTLPLVLYCIYFFFQGAVSKRGINILILLVAIFQFEFISYSFARIFHITNLSVFIFVFNKLLPSLLFNLVLFFVLQPLFERLFGITNKT
>NC_018526.1|WP_012774880.1|24987_26244_+|CHAP-domain-containing-protein
MKKKILATIMLSTVVLSNANYVAVISANDVDSQIATKNQQISELTAQQAEAQQQVDAIQGQVDAIVSEQAKLTEENTRLEAESQTLAADIERLSADIVSRDGALKEQARSAQVDGSASSYINTILDSKSIIDAVSRVNAMREIISANNRMLEQQKADKEAIVEKQKANQEAITTLAANRQKLEDDAQVLQVRQAELEAAKLNLAVQKATAEDEKNSLLVQKAAAEEAARQAAARQAEYQAQQAALAQQQVASVSAPVVSTLVETTVTETVAAPTQTVSQSTPTVSTPTTSTSSGSGSSAAANNARYDASSYPVGECTWGVKSQLSWVGPYWGDAKQWLASARAEGFSTGSTPQVGAIAVWTGGYYGHVAVVTAVQSSTSIQVVESNYMGRRYIGNHRGGYFNPTTTSEGAVYYIYPPY
>NC_018526.1|WP_014917168.1|26346_27315_+|ribose-phosphate-diphosphokinase
MAFTDLKLFALSSNQKLAEQVSKKIGIPLGKSSVRQFSDGEIQVNIEESIRGTHVYILQSTSSPVNDNLMEILIMVDALKRASAESVNVVMPYYGYARQDRKARAREPITSKLVANMLQTAGVNRLLTIDLHAAQIQGFFDIPVDHLMGAPLIADYFERRGMVGDGYVVVSPDHGGVTRVRKLAQFLKTPIAIIDKRRSVDKMNTSEVMNIIGDIKDKTCILIDDMIDTAGTICHAADALADAGATAVYASCTHPVLSGPAMDNISKSAIKKLVVLDTIEIAEDRLIDKIEHISTAELLAEAIIRIHEKRPLSPLFEASRVK
>NC_018526.1|WP_011922532.1|27401_28580_+|pyridoxal-phosphate-dependent-aminotransferase
MDLLNRFNKNLNRIEVSMIRQFDQSISDVPGILKLTLGEPDFTTPDHVKEAAKAAIDADQSYYTGMAGLLELRQAAAEFVAEKYNLHYNPENEILSTIGATEALSASLVAILEAGDTVLLPAPAYPGYEPIVNMVGADIVEIDTTANDFVLTPEMLEEAIIEQGDKLKAVILNYPANPTGVTYSREQIQAFADVLRNYPVFVLSDEVYAELTYTGQPHTSIAEFLPEQTILIQGLSKSHAMTGWRIGLIMSQAPIIAQIIKSHQYLVTAASTAMQYGAVEALKNGKDDALPMRAEYVKRRDYIIEKMTDLGFKIIKPDGAFYIFAKIPAGYNQDSFSFLQDFARKKAVAFIPGAAFGQYGEGYVRISYAASMEKIQTAMARLKEYLEENGTN
>NC_018526.1|WP_002935335.1|28566_29349_+|DNA-repair-protein-RecO
MERIETRGLVLYNRNFREDDKLVKIFTEKAGKRMFFVKHASKSKLVASIQPLTYADFIVKINDDGLSYIEDFHQVQPFKNINGDIFKLSYATYILALADAALQDKVYDPALFAFLVKTLDLMESGLDYEVLTNIFEIQLLGRFGISLNFHECAFCHRVGLPFDYSYKYSGVLCPQHYQQDERRAYLDPNVPYLLDQFQAISFDELETISIKPEMKRKLRFFIDQLYEEYVGIHLKSKKFIDDLSSWGQIMKPRTENEETE
>NC_018526.1|WP_011921644.1|29345_30353_+|phosphate-acyltransferase-PlsX
MKRIAVDAMGGDHAPQAVVEGVNQALAAFPDIEIQLYGDEAKIKQYLTATERVSIVHTTEKINSDDEPVKAIRRKKEASMVLATKAVKDGQADAVLSAGNTGALLAAGVFVVGRIKNIDRPGLMSTLPTMDGKGFDMMDLGANAENIAHHLYQYGILGSFYAEHVRGVKQPRVGLLNNGTEDTKGTPVHQEAYKLLAEDKSINFIGNVEARELLNSVADVVVTDGFTGNAVLKTIEGTAKSIVGQLTGSIKNGGLRAKLGGLLVKPTLKKALGAMDYKTAGGAVLLGLKAPVIKAHGSSDAQSIFYTIKQTRSILEAGIVEKSVAKFSVVEESHD
>NC_018526.1|WP_011921645.1|30345_30594_+|acyl-carrier-protein
MTREQVYQRVVELIQDEKGEDFQVQPESTLADNIAADSVEIMEFVLNLEDEFHVDVPDAAIEHFEVLSDIVDFIYKEVKKRS
>NC_018526.1|WP_011921646.1|30711_31419_+|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MKTDLLYSGKAKDIYATADSDQIVAVYKDQATAFNGGKKEQIVGKGRLNNLISSLIFEKLNEAGVPTHFIKRLSDSEQLNKKVEIIPLEVVLRNVTAGSFSKRFGVEEGITLSTPIVEFYYKKDELDDPFINDEHIAFLELASQDQIAYIKEETRRINEFLKDLFAQIGLTLVDFKLEFGIDSSGQILLADEFSPDNCRLWDADGNHLDKDVFRRGLGELTEVYEVVLAKLQEVK
>NC_018526.1|WP_012774881.1|31431_35151_+|phosphoribosylformylglycinamidine-synthase
MAKRIFVEKKAAFQIKAEALRKELTHNLQLTSLSSLRLVQVYDVFNLEEDLLEQAIKHIFTEQVTDKVLSDEELGLEGAVYFAIEALPGQFDQRAASSQEALLLLGSRQEVRVNTGQLYILNGDVQEEELVAIKNYLLNPVDSRFKDMDAPLVAQEFSVSDTVIPSLDFFDSYGVEEFASYKREAGLAMEVEDLLFIQDYFKSIGRVPTETELKVLDTYWSDHCRHTTFETELRSIDFSASKFQKQLQATYDKYLAMRTELGRTDKPQTLMDMATIFGRYERANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPFGGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITQPLTATRSGKLPQQIISKTAAHGYSSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKENVVREKPVAGDVVILLGGKTGRDGIGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRNGAVTRLIKKSNDFGAGGVCVAIGELADGLEIDLDKVPLKYAGLNGTEIAISESQERMSVVVRPEDVDAFIAACRQENIHAVVVAKVTEKPNLVMTWNGQTIVDLERSFLDTNGVRVVVDAKVVDSPVNLPETRTTSAQTLREDLKDLLSDLNHASQKGLQTIFDSSVGRSTVNHPLGGRHQLTPTESSVQKLPVQQGVTTTASVMAQGYHPYLADWSPYHGAAYAVIEATARLVATGANWSKARFSYQEYFQRMDKQAERFGQPVAALLGSIEAQIQLGLPSIGGKDSMSGTFEDLTVPPTLVAFGVTTADSCKVLSPEFKATGEHIYYLPGQILSEDIDFTLIKSNFKAFEKWQSDYVITAASAVKYGGVLESLALMSFGNQVGARVELADFETSLTGQLGGFVFTSQEDIPDAVKIGQTTTDFTLVVNGVNLSGQDLQVAFEGKLEEVYPTEFEQATELQDVPAVTSSAVIKAKETVEVPVVYIPVFPGTNSEYDSAKAFEQAGAKVNLVPFVTLDAESIENSVDTMVDNIAKANILFFAGGFSAADEPDGSAKFIVTILRNAKVRSAIDQFIEKRGLIIGICNGFQALVKSGLLPYGNFEEAGDTSPTLFYNDANQHIAKMVETRIANVNSPWLAGVQVGDIHAIPVSHGEGKFVVTDEEFATLRDNGQIFSQYVDFTGQPSMDSKYNPNGSSHAIEGITSRNGQIIGKMGHSERYEDGLFQNIPGKKDQGLFVSAVRYFTGK

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Click the colored protein region to show detailed information

Crispr_ID: NC_018526_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018526_2

87427-87557

Orphan

Consensus_repeat	Method
GAGTTGTCTCTTGAGGGACTAGTTAACAGAGGAACGAAAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018526_2

>merge|NC_018526|2|87427-87557|CRISPRCasFinder
GAGTTGTCTCTTGAGGGACTAGTTAACAGAGGAACGAAAAAAGTTTCGAAAAAGTGTTGACAAGACCATCAGAAGATGATAGACTAATGGAGTTGTCTCTTGAGGGACTGGTTAACAGAGGAACGAAAAAA

>NC_018526|2|2|87427-87557|CRISPRCasFinder
GAGTTGTCTCTTGAGGGACTAGTTAACAGAGGAACGAAAAAA	GTTTCGAAAAAGTGTTGACAAGACCATCAGAAGATGATAGACTAATG
GAGTTGTCTCTTGAGGGACTGGTTAACAGAGGAACGAAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_018526.1\|WP_012774898.1\|86728_87115_+\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NC_018526.1\|WP_011921708.1\|99722_99932_+\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219
NC_018526.1\|WP_002936636.1\|82418_83729_+\|preprotein-translocase-subunit-SecY	unknown	unknown	gnl\|CDD\|236412
NC_018526.1\|WP_001808836.1\|84828_84945_+\|50S-ribosomal-protein-L36	unknown	unknown	gnl\|CDD\|376334
NC_018526.1\|WP_002936638.1\|81646_81829_+\|50S-ribosomal-protein-L30	unknown	unknown	gnl\|CDD\|180163
NC_018526.1\|WP_002936595.1\|95938_96643_+\|metal-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224046
NC_018526.1\|WP_002936637.1\|81964_82405_+\|50S-ribosomal-protein-L15	unknown	unknown	gnl\|CDD\|235523
NC_018526.1\|WP_002936627.1\|84585_84804_+\|translation-initiation-factor-IF-1	unknown	unknown	gnl\|CDD\|178954
NC_018526.1\|WP_012774904.1\|95494_95938_+\|winged-helix-DNA-binding-protein	unknown	unknown	gnl\|CDD\|197670
NC_018526.1\|WP_012774905.1\|99959_100337_-\|HIT-family-protein	unknown	unknown	gnl\|CDD\|223611
NC_018526.1\|WP_002936630.1\|83822_84464_+\|adenylate-kinase	unknown	unknown	gnl\|CDD\|234711
NC_018526.1\|WP_014636196.1\|94770_95046_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271189
NC_018526.1\|WP_002936622.1\|84964_85330_+\|30S-ribosomal-protein-S13	unknown	unknown	gnl\|CDD\|235358
NC_018526.1\|WP_004195509.1\|85347_85731_+\|30S-ribosomal-protein-S11	unknown	unknown	gnl\|CDD\|180007
NC_018526.1\|WP_011921705.1\|97457_98969_+\|zinc-ABC-transporter-substrate-binding-protein-AdcA	unknown	unknown	gnl\|CDD\|238499
NC_018526.1\|WP_014636197.1\|99071_99542_+\|CopY/TcrY-family-copper-transport-repressor	unknown	unknown	gnl\|CDD\|131745
NC_018526.1\|WP_002936593.1\|96635_97448_+\|metal-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|334323
NC_018526.1\|WP_011921691.1\|85775_86714_+\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NC_018526.1\|WP_011922558.1\|100394_101651_-\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NC_018526.1\|WP_014917174.1\|93991_94774_+\|DUF2971-domain-containing-protein	unknown	unknown	gnl\|CDD\|378585

Protein	Function_ID	Function_description	E-value
NC_018526.1\|WP_012774898.1\|86728_87115_+\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	2.6132e-66
NC_018526.1\|WP_011921708.1\|99722_99932_+\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	1.5654e-09
NC_018526.1\|WP_002936636.1\|82418_83729_+\|preprotein-translocase-subunit-SecY	gnl\|CDD\|236412	PRK09204, secY, preprotein translocase subunit SecY; Reviewed.	3.43842e-180
NC_018526.1\|WP_001808836.1\|84828_84945_+\|50S-ribosomal-protein-L36	gnl\|CDD\|376334	pfam00444, Ribosomal_L36, Ribosomal protein L36.	5.19122e-15
NC_018526.1\|WP_002936638.1\|81646_81829_+\|50S-ribosomal-protein-L30	gnl\|CDD\|180163	PRK05611, rpmD, 50S ribosomal protein L30; Reviewed.	6.71487e-29
NC_018526.1\|WP_002936595.1\|95938_96643_+\|metal-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	3.88616e-106
NC_018526.1\|WP_002936637.1\|81964_82405_+\|50S-ribosomal-protein-L15	gnl\|CDD\|235523	PRK05592, rplO, 50S ribosomal protein L15; Reviewed.	3.86637e-85
NC_018526.1\|WP_002936627.1\|84585_84804_+\|translation-initiation-factor-IF-1	gnl\|CDD\|178954	PRK00276, infA, translation initiation factor IF-1; Validated.	3.25516e-47
NC_018526.1\|WP_012774904.1\|95494_95938_+\|winged-helix-DNA-binding-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.12951e-14
NC_018526.1\|WP_012774905.1\|99959_100337_-\|HIT-family-protein	gnl\|CDD\|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	7.56885e-23
NC_018526.1\|WP_002936630.1\|83822_84464_+\|adenylate-kinase	gnl\|CDD\|234711	PRK00279, adk, adenylate kinase; Reviewed.	4.90526e-116
NC_018526.1\|WP_014636196.1\|94770_95046_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	5.30548e-16
NC_018526.1\|WP_002936622.1\|84964_85330_+\|30S-ribosomal-protein-S13	gnl\|CDD\|235358	PRK05179, rpsM, 30S ribosomal protein S13; Validated.	3.4104e-76
NC_018526.1\|WP_004195509.1\|85347_85731_+\|30S-ribosomal-protein-S11	gnl\|CDD\|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	1.51827e-85
NC_018526.1\|WP_011921705.1\|97457_98969_+\|zinc-ABC-transporter-substrate-binding-protein-AdcA	gnl\|CDD\|238499	cd01017, AdcA, Metal binding protein AdcA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AdcA proteins belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. They are comprised of two globular subdomains connected by a long alpha helix and they bind their ligand in the cleft between these domains. In addition, many of these proteins have a low complexity region containing metal binding histidine-rich motif (repetitive HDH sequence).	3.25216e-133
NC_018526.1\|WP_014636197.1\|99071_99542_+\|CopY/TcrY-family-copper-transport-repressor	gnl\|CDD\|131745	TIGR02698, Uncharacterized_16.5_kDa_protein_in_ptsI_3'region, copper transport repressor, CopY/TcrY family. This family includes metal-fist type transcriptional repressors of copper transport systems such as copYZAB of Enterococcus hirae and tcrYAZB (transferble copper resistance) of an Enterocuccus faecium plasmid. High levels of copper can displace zinc and prevent binding by the repressor, activating efflux by copper resistance transporters. The most closely related proteins excluded by this model are antibiotic resistance regulators including the methicillin resistance regulatory protein MecI. [Transport and binding proteins, Cations and iron carrying compounds, Regulatory functions, DNA interactions].	8.80717e-41
NC_018526.1\|WP_002936593.1\|96635_97448_+\|metal-ABC-transporter-permease	gnl\|CDD\|334323	pfam00950, ABC-3, ABC 3 transport family.	3.22087e-65
NC_018526.1\|WP_011921691.1\|85775_86714_+\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	1.9769e-179
NC_018526.1\|WP_011922558.1\|100394_101651_-\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NC_018526.1\|WP_014917174.1\|93991_94774_+\|DUF2971-domain-containing-protein	gnl\|CDD\|378585	pfam11185, DUF2971, Protein of unknown function (DUF2971). This bacterial family of proteins has no known function.	4.47073e-06

>NC_018526.1|WP_012774898.1|86728_87115_+|50S-ribosomal-protein-L17
MAYRKLGRTSSQRKAMLRDLTTDLLINESIVTTEARAKEIRKTVEKMITLGKRGDLHARRQAAAFVRNEIASENYDEATDKYTSATALQKLFSEIAPRYAERNGGYTRILKTEPRRGDAAPMAIIELV
>NC_018526.1|WP_011921691.1|85775_86714_+|DNA-directed-RNA-polymerase-subunit-alpha
MIEFEKPTITKIDENKDYGRFVIEPLERGYGTTLGNSLRRVLLASLPGAAVTSIKIDGVLHEFDTVPGVREDVMQIILNIKGIAVKSYVEDEKKIELDVVGPAEVTAGDILTDSDIEIVNPDHYLFTIADGATFKAVLTVNSGRGYVPAEDNKKDDAPVGTLAVDSIYTPVKKVNYQVEPARVGSNDGFDKLTLEINTNGTIIPEDALGLSARILMEHLGLFTDLTEVAKSAEVMKEAEVASDDRMLDRTIEELDLSVRSYNCLKRAGINTVFDLTEKTEPEMMKVRNLGRKSLEEVKVKLADLGLGLKKDK
>NC_018526.1|WP_004195509.1|85347_85731_+|30S-ribosomal-protein-S11
MAKPTRKRRVKKNIESGIAHIHATFNNTIVMITDVHGNAIAWSSAGALGFKGSRKSTPFAAQMASEAAAKSAQEHGLKTVEVTVKGPGSGRESAIRALAAAGLEVTAIRDVTPVPHNGARPPKRRRV
>NC_018526.1|WP_002936622.1|84964_85330_+|30S-ribosomal-protein-S13
MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGISEDVRVKDLTSDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNTKNNARTRKGKAVAIAGKKK
>NC_018526.1|WP_001808836.1|84828_84945_+|50S-ribosomal-protein-L36
MKVRPSVKPICEYCKVIRRNGRVMVICPANPKHKQRQG
>NC_018526.1|WP_002936627.1|84585_84804_+|translation-initiation-factor-IF-1
MAKEDVIEIEGKVVDTMPNAMFTVELENGHQVLATVSGKIRKNYIRILVGDRVTVELSPYDLTRGRITYRFK
>NC_018526.1|WP_002936630.1|83822_84464_+|adenylate-kinase
MNLLIMGLPGAGKGTQAAKIVEKFNVAHISTGDMFRAAMANQTEMGILAKSYIDKGDLVPDEVTNGIVKERLVQDDIKEKGFLLDGYPRTIEQAHALDENLADLGIELQGVINIEIDPSKLVERLSGRIIHKETGETFHKVFNPPVGDYKEEDFYQREDDKPESVKRRLEVNIAQGQPIIDHYRAKGLVHDIEGDQDIDLVFQAIDTVLSKLQ
>NC_018526.1|WP_002936636.1|82418_83729_+|preprotein-translocase-subunit-SecY
MFFKLLKDALKVKLVRSKILFTIFILFVFRVGTHITVPGVNAKSLEALSNLPFLNMLSLVSGNAMRNFSVFALGVSPYITASIIVQLLQMDILPKFVEWGKQGEVGRRKLNQATRYISLVLAFVQSIGITAGFNALSGAKLTNMPLNWQTYLLIGAILTTGSIIVTWLGEQISEKGYGNGTSMIIFAGIISSLPGTFHEIYIDRFVNIESSRLGESAIFVAALVVLIFFVVYFTTFVQQAEYKLPIQYTKRAQGAPSSSYLPLKLNPAGVIPVIFAGSITAVPTSLIQYFASQNKSAGWLLTVQEYFDYSTAKGMIVYAGLIIAFTFFYTFVQVNPEKTAESLQKSAAYIHGVRPGNGTEQFLSKLLTRLAVIGALFLSFVALLPILAQNLFGLSSSIAFLGTSLIIVISTSIEGIKQLEGYLLKRKYVGFLEITE
>NC_018526.1|WP_002936637.1|81964_82405_+|50S-ribosomal-protein-L15
MKLHELQPATGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGGGVRPGFEGGQTPLFRRLPKRGFTNINAKEYAIVNLDQLNAFEDGAEVTPVVLIEAGIVKAEKSGIKILGNGELTKKLTVKAAKFSKSAEEAITSKGGSVEVI
>NC_018526.1|WP_002936638.1|81646_81829_+|50S-ribosomal-protein-L30
MAQIKITLTKSPIGRKPEQRKTVVALGLGKLNSSVVKEDNPAILGMVNAISHLVTVEEVK
>NC_018526.1|WP_014917174.1|93991_94774_+|DUF2971-domain-containing-protein
MKTLYHYTTVETLLLILNYKTLRFKSLLYVDDPLEPSTSDFGNLGGFKYVSCWTDTPNSIPQWTMYSDNMTGVCIGISFDKETDVFLTEKFSLSESSEPIDMVNALHPLKSGLLVTNNKYVPSLEQIRYTDDISLITPRVVSSDDKSTTINLASNGIYKTTDWSFQNEQRFSFQIFPLPIDLVLELMNANKGDLTEIINSFISVKPKEYFDLDLNPTIFSNMTITFGKRCSAEDKLKVSKFLEDNKFHIPLFDSTVNIKP
>NC_018526.1|WP_014636196.1|94770_95046_-|tyrosine-type-recombinase/integrase
MSVFQSSPITITKNSIEKQYKKILERDAALKKIRIHDFRHSHASLLINRGEDYLVVKERLGHAFITTSIDTYSHLYPSKQKDLADKLDDLI
>NC_018526.1|WP_012774904.1|95494_95938_+|winged-helix-DNA-binding-protein
MNRIALEIEKYLHEIVLSSENQLEILVGSCQSTVKLTNTQEHILMLIEKAAYTNTEIAKELNVSQAAITKATKSLVAQGLLVAVRDDKDARIVRFSLTEAAKPIAAEHAHHHAHTLEAYEELLENYSLEEQESIARFLSELVEKIRK
>NC_018526.1|WP_002936595.1|95938_96643_+|metal-ABC-transporter-ATP-binding-protein
MRYITVEDLSFYYDKEPVLEHIHYYLDSGEFVTLTGENGAAKTTLIKATLGILKPKQGKVSIAEKSIKGKKLRMAYLPQQIASFNAGFPSTVYEFVKSGRYPRQGWFRRLTAHDEEHVRISLESVGMWEHRDKRLGALSGGQKQRAVIARMFASDPDIFILDEPTTGMDAGTKDAFYQLMHHSAKKHGKSVLMITHDPDELNKYADRNIHLVRDQQSPWRCFNVHEADEEVAHV
>NC_018526.1|WP_002936593.1|96635_97448_+|metal-ABC-transporter-permease
MFDLSVFHYDFMQRAFLAIIAMSLFSPILGVFLILRRQSLMSDTLSHVSLAGVAFGLVLGISPTLSTVLVVIVAAVFLEYLRTIYKNFMEIGTAILMSTGLAISLIVMNKSGGKSGLSLEQYLFGSIVTISQEQVIALFTIAVIVIVLTLLFLRPMYILTFDEDTAFVDGLPVRAMSIAFNVVTGVAIALMIPAAGALLVSTIMVLPASIALRLGKSFKAVIFTGMGIGFFGMVMGLLTSYYAETPASASITLIFISIFLLVNVVQKFKK
>NC_018526.1|WP_011921705.1|97457_98969_+|zinc-ABC-transporter-substrate-binding-protein-AdcA
MKKVGLLFLSVSALLLGACGNSTASEDGKLNIVTTFYPVYEFTKQVAGDEANVDLLVKAGTEVHGYEPSAKDIARIQEADAFVYENENMETWVHDVEKSLDTTKVNVISATEGMLLLPGGEEEHEGHDHSEEGHSHAYDPHVWLSPERAITLVENIRDSLVAKYPEKKDAFETNAAAYIEKLDALDAKYSETLSAAKQKYFVTQHTAFAYLALDYGLKQVSITGVAADEDPTPSRLAELTEYINKYGIKYIYFEENASKSVAETLAKETGVQLDVLNPLESLTDEDMKNGKDYISVMEDNLIALEKTTSQEGSEILPEEGAETAQTVYNGYFEDSAVKDRTLSDYAGEWQSVYPYLLDGTLDQVWDYKAKIKGGMTAEEYKTYYDTGYKTDVDQINITDNTMEFVVGDKKEKFTYKYVGYKILTYKKGNRGVRFLFEATDANAGNYKYVQFSDHNIAPVKTGHFHIYFGGESQEKLLEELENWPTYYPVGLTGLEIGQEMLAH
>NC_018526.1|WP_014636197.1|99071_99542_+|CopY/TcrY-family-copper-transport-repressor
MEQTISAAEWQVMRVLWAHPGATSQEIIQALQEGFDWQATTIKTLLGRLRKKNYLRMAKETSKYHYYPLISEEEHLQGQVELLLAAICSTKQGQLVEKLLDTGTFSKKSLENLASKISQLQRTAPEQIACRCLAGQCTCGHHHTLRKSTSDVVDLT
>NC_018526.1|WP_011921708.1|99722_99932_+|heavy-metal-associated-domain-containing-protein
MKQTLKLKNLSCQNCVKHVTNHLLDLDGVEEVKIQLEEQLAEVATSVAYDLERYQEVLEDTIYEVEELV
>NC_018526.1|WP_012774905.1|99959_100337_-|HIT-family-protein
MTCIFCHQIEEIDILYQTEYFKVVWDIDPIQTGHLLIISKDHYDTLSQVPPTIRYELSDLEVFLTEKLCQTLAIDGVTTACNDRLFNAGTHFHVHLIPRFRSDGFWDQISLAQAQLDLTHFLKAL
>NC_018526.1|WP_011922558.1|100394_101651_-|tyrosine--tRNA-ligase
MNIFEELKARGLVFQTTDEEALVKALTEGQVSYYTGYDPTADSLHLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKDTVDGWVTKIQGQLSRFLDFENGDNKAEMVNNYDWFSDISFIDFLRDVGKYYTVNYMMSKDSVKKRIETGISYTEFAYQIMQGYDFYELNDKHNVTLQIGGSDQWGNMTAGTELLRRKADKSGHVMTVPLITDSTGKKFGKSEGNAVWLDADKTSPYEMYQFWLNVMDDDAVRFLKIFTFLSLDEIAEIEKQFDAARHERLAQKILAKEVVTLVHGEEAYNQALNITEQLFAGNIKNLSAKELKQGLSNVPNYAVQAEDNLNIVELLVTSGIVNSKRQAREDVQNGAIYVNGERVQDLDYTLSDSDKIDGELTVIRRGKKKYSVLTY

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_018526_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018526_3

382055-382268

Orphan

Consensus_repeat	Method
TAAAAGGTTGGAGATTGGAA	PILER-CR

3 spacers

The CRISPR arrays of NC_018526_3

>merge|NC_018526|3|382055-382268|PILER-CR
TAAAAGGTTGGAGATTGGAATCGTCGGTAGACGATTCTCATTGTACGTGGGACGTCCTAGAAGGTTGGAGATTGGAACTGCCGTGCCGGCAGGCAGTTTTCTTTATACTCAAAAGTCCGGGGGACAGTCATTTTTATTAAAAGGTTGGAGATTGGAATCGTCGGTAGACGATTCTCATTGTACGTGGGATGTCCTAGAAGGTTGGAGATTGGAA

>NC_018526|3|1|382055-382268|PILER-CR
TAAAAGGTTGGAGATTGGAA	TCGTCGGTAGACGATTCTCATTGTACGTGGGACGTCC
TAGAAGGTTGGAGATTGGAA	CTGCCGTGCCGGCAGGCAGTTTTCTTTATACTCAAAAGTCCGGGGGACAGTCATTTTTAT
TAAAAGGTTGGAGATTGGAA	TCGTCGGTAGACGATTCTCATTGTACGTGGGATGTCC
TAGAAGGTTGGAGATTGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_018526.1\|WP_011922666.1\|380191_380818_-\|DUF2812-domain-containing-protein	unknown	unknown	gnl\|CDD\|378589
NC_018526.1\|WP_012774980.1\|384042_384963_+\|hypothetical-protein	unknown	unknown	unknown
NC_018526.1\|WP_009909407.1\|385175_386159_+\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|234663
NC_018526.1\|WP_011922661.1\|372228_373737_+\|4-alpha-glucanotransferase	unknown	unknown	gnl\|CDD\|237738
NC_018526.1\|WP_011921968.1\|377127_377919_+\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197313
NC_018526.1\|WP_011921974.1\|383389_383935_+\|ECF-type-riboflavin-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|184218
NC_018526.1\|WP_012774978.1\|369946_372046_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NC_018526.1\|WP_011921978.1\|386845_388519_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NC_018526.1\|WP_012774979.1\|373729_375994_+\|glycogen/starch/alpha-glucan-family-phosphorylase	unknown	unknown	gnl\|CDD\|340853
NC_018526.1\|WP_171840875.1\|386416_386728_+\|lactoylglutathione-lyase	unknown	unknown	gnl\|CDD\|226134
NC_018526.1\|WP_011921981.1\|390525_392712_-\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|273955
NC_018526.1\|WP_004194195.1\|381300_382017_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|237084
NC_018526.1\|WP_004194196.1\|380828_381140_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|163261
NC_018526.1\|WP_004194205.1\|376221_376929_-\|UTRA-domain-containing-protein	unknown	unknown	gnl\|CDD\|274116
NC_018526.1\|WP_012774977.1\|369231_369642_+\|peptide-deformylase	unknown	unknown	gnl\|CDD\|181704
NC_018526.1\|WP_004194192.1\|382520_383369_+\|S-adenosyl-l-methionine-hydroxide-adenosyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224824
NC_018526.1\|WP_004195223.1\|389508_389712_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_018526.1\|WP_011922665.1\|377952_380121_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|131058
NC_018526.1\|WP_011921980.1\|389753_390467_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NC_018526.1\|WP_011921979.1\|388515_389349_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692

Protein	Function_ID	Function_description	E-value
NC_018526.1\|WP_011922666.1\|380191_380818_-\|DUF2812-domain-containing-protein	gnl\|CDD\|378589	pfam11193, DUF2812, Protein of unknown function (DUF2812). This is a bacterial family of uncharacterized proteins, however some members of this family are annotated as membrane proteins.	6.08987e-21
NC_018526.1\|WP_009909407.1\|385175_386159_+\|rhodanese-related-sulfurtransferase	gnl\|CDD\|234663	PRK00142, PRK00142, rhodanese-related sulfurtransferase.	0
NC_018526.1\|WP_011922661.1\|372228_373737_+\|4-alpha-glucanotransferase	gnl\|CDD\|237738	PRK14508, PRK14508, 4-alpha-glucanotransferase; Provisional.	0
NC_018526.1\|WP_011921968.1\|377127_377919_+\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197313	cd09079, RgfB-like, Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins. This family includes Streptococcus agalactiae RgfB (for regulator of fibrinogen binding) and related proteins. The function of RgfB is unknown. It is part of a putative two component signal transduction system designated rgfBDAC (the rgf locus was identified in a screen for mutants of Streptococcus agalactiae with altered binding to fibrinogen). RgfA,-C,and -D do not belong to this superfamily: rgfA encodes a putative response regulator, and rgfC, a putative histidine kinase. All four genes are co-transcribed, and may be involved in regulating expression of bacterial cell surface components. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.	6.73631e-125
NC_018526.1\|WP_011921974.1\|383389_383935_+\|ECF-type-riboflavin-transporter-substrate-binding-protein	gnl\|CDD\|184218	PRK13661, PRK13661, ECF-type riboflavin transporter substrate-binding protein.	8.67718e-92
NC_018526.1\|WP_012774978.1\|369946_372046_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NC_018526.1\|WP_011921978.1\|386845_388519_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	5.22213e-92
NC_018526.1\|WP_012774979.1\|373729_375994_+\|glycogen/starch/alpha-glucan-family-phosphorylase	gnl\|CDD\|340853	cd04300, GT35_Glycogen_Phosphorylase, glycogen phosphorylase and similar proteins. This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism. The allosteric control mechanisms of yeast and mammalian members of this family are different from that of bacterial members. The members of this family belong to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	0
NC_018526.1\|WP_171840875.1\|386416_386728_+\|lactoylglutathione-lyase	gnl\|CDD\|226134	COG3607, COG3607, Predicted lactoylglutathione lyase [General function prediction only].	2.17243e-18
NC_018526.1\|WP_011921981.1\|390525_392712_-\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NC_018526.1\|WP_004194195.1\|381300_382017_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|237084	PRK12378, PRK12378, YebC/PmpR family DNA-binding transcriptional regulator.	7.09301e-135
NC_018526.1\|WP_004194196.1\|380828_381140_-\|transcriptional-regulator	gnl\|CDD\|163261	TIGR03433, padR_acidobact, transcriptional regulator, Acidobacterial, PadR-family. Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions].	2.51666e-11
NC_018526.1\|WP_004194205.1\|376221_376929_-\|UTRA-domain-containing-protein	gnl\|CDD\|274116	TIGR02404, Trehalose_operon_transcriptional_repressor, trehalose operon repressor, B. subtilis-type. This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions].	3.21951e-64
NC_018526.1\|WP_012774977.1\|369231_369642_+\|peptide-deformylase	gnl\|CDD\|181704	PRK09218, PRK09218, peptide deformylase; Validated.	1.94042e-84
NC_018526.1\|WP_004194192.1\|382520_383369_+\|S-adenosyl-l-methionine-hydroxide-adenosyltransferase-family-protein	gnl\|CDD\|224824	COG1912, COG1912, Uncharacterized conserved protein [Function unknown].	2.06971e-121
NC_018526.1\|WP_004195223.1\|389508_389712_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	5.32735e-32
NC_018526.1\|WP_011922665.1\|377952_380121_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|131058	TIGR02003, PTS_system_glucose-specific_IIBC_component, PTS system, IIBC component. This model represents a family of fused B and C components of PTS enzyme II. This clade is a member of a larger family which contains enzyme II's specific for a variety of sugars including glucose (TIGR02002) and N-acetylglucosamine (TIGR01998). None of the members of this clade have been experimentally characterized. This clade includes sequences from Streptococcus and Enterococcus which also include a C-terminal A domain as well as Bacillus and Clostridium which do not. In nearly all cases, these species also contain an authentic glucose-specific PTS transporter. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NC_018526.1\|WP_011921980.1\|389753_390467_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	9.06801e-85
NC_018526.1\|WP_011921979.1\|388515_389349_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	2.31637e-38

>NC_018526.1|WP_004194195.1|381300_382017_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKKGDPDPETNSALKFVIDRAKQAQVPKHIIDKAIDKAKGNTDETFVEGRYEGFGPNGSMIIVDTLTSNVNRTAANVRSAFGKNGGNMGASGSVSFMFDKKGVVVFAGDDADAIFELLLEADVEVDDVEAEDGTITVYTAPTDLHKAIVALKESGIQEFNVTELEMIPQSEVSLEGDDLATFEKLYDALEDDEDVQKIYTNVDGF
>NC_018526.1|WP_004194196.1|380828_381140_-|transcriptional-regulator
MKRNKHLPLTETTYYILLALLEPAHGYHIMQKVEDMSDGDVKIAAGTMYGAIENLLKLKWICSVPSSDKRRKVYQVTATGQEIIKLETQRIQKLHHIAKELGF
>NC_018526.1|WP_011922666.1|380191_380818_-|DUF2812-domain-containing-protein
MIRHKLFTSLQEEEHWINSIQSEGYQLVKVTPWTATYHFEKCSRTPHPVRLDFHEHIAKGEYSNYLSLFEDCGWQPIQGSRRCGIHYFQQTIETSSTEIFSDTESKKAFYSRYQNYAYSYFGLFLTLFFIHYQVGLQNGYTLWNPKSWYLTPGLWERTGTSFWFGFLFETPFALFRSGIIPLFFLAWSIYFLHIAEKGKKEAKKLEKY
>NC_018526.1|WP_011922665.1|377952_380121_+|PTS-transporter-subunit-EIIC
MKKFLSFEFWQKFGKCLMVVIAVMPAAGLMVSIGNSIPLISPESELLIRIGNIIAQIGWGIIGNLHLLFALAIGGSWAKEKAGGAFSAGLAFILINLITGHFFGVTTDMLADAAATVTTVFGTEIPVSGYFVNILGQPALNMGVFVGIIAGFVGATTYNKYYNYRKLPDVLTFFNGKRFVPFVVIYRSVLVALGLAIFWPVVQTGINSFGKWIASSQDTAPILAPFVYGTLERLLLPFGLHHMLTIPMNYTSLGGTYDILTGAQAGTQVFGQDPLWLAWITDLINLKDAGDMAQYNDLLANITPARFKVGQMIGSSGILMGLTYAMYRNVDEDKKHKYKGMFISSALAVFLTGVTEPIEFMFMFAAMPLYVVYAFVQGAAFAMADIVNLRMHSFGNIEFLTRTPMAIKAGIGMDVINFIWVTALFAVGMYFIANFMIKKFNLATAGRNGNYDTETTDVVSNSNVDTADANSQVVQIINLLGGRDNIADVDACMTRLRVSVKDVAQVGDENAWKQAGAMGLIIKDSGVQAVYGPKADVLKSDIQDLLESGVAIPRTEIVATEEVAPETQFKGVTETVYSVAEGQAIAITEVKDPVFSQKMMGDGYAVEPSSGNVYAPVSGIVTSVFPTKHAVGILSDKGVEVLVHVGLDTVALNGAPFSTKVTDGQRVEAGDLLLVADLEAIRSAGRETTIVVAFTNTAEIKSVSLENLGQVSQDSQVATVEL
>NC_018526.1|WP_011921968.1|377127_377919_+|endonuclease/exonuclease/phosphatase-family-protein
MKLLTINVHAWLEERQDEKLDVLAQTIAEKAYDVIALQEVNQLITADLVTKDLKADNYGLILLEKLRTLGQFDYSYYWSNSHIGYDKYEEGIAFLTKLPVYEVDQFYCSQNKSIDSILSRKIMGLTVFYQDQLIDLYSCHINLPGSEEEDQLDNIRTIVERTGNRRFKILMGDFNTDAFSDREAYEAITELGLYDSYNLAMEKDQGITVEKAIDGWAGHSQEKRLDYIFLNQKKEVLSSLVIFNGENRPIISDHFGVEVEINV
>NC_018526.1|WP_004194205.1|376221_376929_-|UTRA-domain-containing-protein
MSKYKKVYQDIKKKIEEQVWSTGQALPTENELMEVYSYSKDTIRKALSLLEMDGYIQKKQGKSSIVIEHGLMKDQYLSEIKTAGELNKRSQHQIQTQLTSLYIIQGQEDLMSTFEVDDKVDFYRVSRVRTIDGERLEYDISYFDRRVVPYLSKEIAESSIYRYLEEELHLTISHSRREISFRFANEEEKQLMDLGDYDMVVVVTSITYLSNGQAFQYGTISYRPDKVSFVSMAKR
>NC_018526.1|WP_012774979.1|373729_375994_+|glycogen/starch/alpha-glucan-family-phosphorylase
MTKFTTFAETNTSKKLADLTNEEIYLQLLNYVKDAAASKPKNTGKRKVYYISAEFLIGKLLSNNLINLGVYKDVQAELAAAGKSLAQVEDVEPEPSLGNGGLGRLASCFVDSMSTLAINGEGVGLNYHCGLFRQVFKKNEQEAEPNFWIENDSWLIPTTISYDVPFKNFTLKSKLDRLDILGYKKETKNYLNLFDIESVNYDLITDGISFDKTDIKENLTLFLYPDDSDKNGELLRIYQQYFMVSNAAQLLIDEAIERGSNLHDLADYAYVQINDTHPSMVIPELIRLLTEKHGIEFAEAVAIVKNMTGYTNHTILAEALEKWPLEFLEEVVPHLVDIIKELDALIRAEIKDPAVQIIDESGRVHMAHMDIHFSNSVNGVAALHTEILKNSELKAFYELYPEKFNNKTNGITFRRWLEFANQDLADYIKELIGDEYLTDATKLEKLLAFADDKEVHAKLAEIKFNNKLALKRYLKDNKGIELDENSIIDTQIKRFHEYKRQQMNALYVIHKYLEIKNGNLPKRKITVIFGGKAAPAYIIAQDIIHLILCLSELINNDPEVNKYLNVHLVENYNVTVAEKLIPATDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAELAGMDNIYTFGKDSDTIIDLYDKAGYVSADYYNGDANIKRAVDFIVSDEVKALGNEERLGRLHHELISKDWFMTLIDLAEYIEVKEQVFADYEDQDSWNKKVVHNIAKAGFFSSDRTIEQYNEDIWHSN
>NC_018526.1|WP_011922661.1|372228_373737_+|4-alpha-glucanotransferase
MTNRTSGILMHITSLPGKFGIGTFGQSAYDFVDFLVETKQTYWQILPLTTTSYGDSPYQSFSAIAGNTHLIDFDLLVEDGLLATEDFQDVNFGDNPEKVDYALIYQVRRPILEKAVQAFLQDDKKKAAFLEFEKANSSWLTDYAEFMAIKEYFGNKALQEWEDKKVVARNEEALDKYRLELANQIDYYKVTQYFFFSQWKQLKEYANKHHIKIIGDMPIYVSADSVEVWTKPQLFKLDSERKPLYVAGVPADNFSADGQLWGNPIYDWPEHEKTGYNWWIYRIHESFKLYDVLRIDHFKGFSDFWQVDGKAEVAKVGTWEPGPGYNLFKAVKETLGDLPIIAEDLGNIDAKARKLLADCGYPGMKILEFGFFDVTGKSIDAPHRCIPNSVAYTGTHDNEVVNGWYNNLDPEQQEYVDAYSNRKPIEKVSQAMLRMLFATVSDTAIATMQDVLDLGEESRMNMPSTIGGNWEWRMKAEDLTQERKDFLTKMTLLYQRGNENHD
>NC_018526.1|WP_012774978.1|369946_372046_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MNNNFNNFNNMDDIFNQLMGNMGGYSTERRRYSINGREVTPEEFAMYRQTGRLPQTEEVAQTQAKGQIKSDGILAKLGRNLTQDAREGKLDPVIGRNKEIQETSEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEAGTQYRGAFEENVQNLVDEVKKAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTIHKNAALARRFNEVKVNAPSAEDTYQILKGIKPLYEAHHNIELPDEVLRAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAAQHPVTDIQTLEAEMAEAKQLQLEAAEKEDYEKALNEKVRIDKLQKQIDNHTEQQKVVATVNDVAQAVERMTGIPVSQMGASDIERLKELKNRLAANVIGQDDAVEAVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGNKDAIIRLDMSEYSDRTAVSKLIGTTAGYIGYDDNSHTLTERVRRNPYSIVLMDEIEKADPQVITLLLQVLDDGHLTDGQGNQVNFKNTIIIATSNAGFGYGMAEGEENQDIMDRIAPFFRPEFLNRFNAVIEFKHLDKDDLKAIVELLLAQVNNTLAKKGIQLTVTEAAKEFLMEEGYDKAMGARPLRRVIENQIRDKVTDFYLDHVDVKYLEADVVDGSIQIKEQSFA
>NC_018526.1|WP_012774977.1|369231_369642_+|peptide-deformylase
MIQPIMKDIFFLQQKSEPATQLDVQVGQDLQDTLAANAHACVGMAANMIGVKKRIIIVNMGFTNLVMYNPVLISKAKPYQTEEGCLSLEGTRPTTRYQEIEVEFFDASWKKISLKLTDFQAQIVQHELDHLEGIII
>NC_018526.1|WP_004194192.1|382520_383369_+|S-adenosyl-l-methionine-hydroxide-adenosyltransferase-family-protein
MSNNLLVLQSDFGLVDGAVSAMIGVALQESRDLVVHHLTHDITPYNIFEGSYRLFQTVEYWPEGTTFVSVVDPGVGSKRKSVVALTEQNHYIVTPDNGTLSFIKKYVGIKAVREISEVANRRANTEHSYTFHGRDVYAYTGAKLASGHISFEEVGPELSVDKIVEIPTVPTEVGSDYVKGAIDILDVRFGSLWTSITREEFYTLQPQFEDRFEVTIYNNDMLVYQNQVTYGKSFADVRIGQPLIYINSLYRVGVAINQGSFAKAYNVGVGQNWHIEIKRISN
>NC_018526.1|WP_011921974.1|383389_383935_+|ECF-type-riboflavin-transporter-substrate-binding-protein
MKNNSIKTVVATGIGAALFVVIGHLINIPTFVPNTSIQLQYAVQSLLAVVFGPVVGFLVGFIGHTLKDSLTYGPWWSWILASGVFGLVVGLTKKRLRIQEGIFEGKDILFFNLVQIAANVLAWGVIAPVLDILIYSEAANKVFAQGLVAGIANSITIAIAGTLLLVVYAKSQTKTGSLSKD
>NC_018526.1|WP_012774980.1|384042_384963_+|hypothetical-protein
MVWTEEKLGPIIHSILNPDEEVLSLYQSKTTKSIYGCILWNNYYYKVFRVSNHPSQSTYKQPTFYDFHGEFYMKGAIRTYLYHTNSWYELSKQGYYLLLFFQKLWDEKQEVEASWQNGRMQIRLVVEEEGWQVHYRFPDNQAREVERLLGSGMLVAIRSSRNFIKIRTSRFVAPYIALIKQRQLYRKKPSKAMLQWEKYQSQLIEIQRTYRLVEESAPQTFFGHWLNKVQLYLCSAIASYWEEVIKGVEWQEAREIKEQRKAEKPHNPIEDKWKENIARRHKRKMDQLIGHDTLEKLRQLKTELDD
>NC_018526.1|WP_009909407.1|385175_386159_+|rhodanese-related-sulfurtransferase
MSKDIRVLLYYKYVPIENAKEYAAEHLAFCKSIGLKGRILIADEGINGTVSGDYETTQKYMDYVHANPLFSDLWFKIDEENEQAFKKMFVRYKKEIVHLGLEDNDFDNDIDPLVTTGAYLSPKEFKEALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVRGELWDGKMYVFDERIAVDVNHVNPVVVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEHKYVRGCSAECRAHERNRYISENGLTRQEWAERLEAIGETLTPANA
>NC_018526.1|WP_171840875.1|386416_386728_+|lactoylglutathione-lyase
MAGRFYEAIGFAVATFGDIKSATLPKGGNLILMQADSFAQRVPFQVVASGNEVLISLNVASREEVDRIIERVEANGGQITGCPTDARGFYGASFTDLDGIILM
>NC_018526.1|WP_011921978.1|386845_388519_+|ABC-transporter-ATP-binding-protein
MKKIIEFKDFTFKYQAQQEPTLKDIQLTIYQGEKVLIIGPSGSGKSTIGQCLNGIIPNIYKGEHSGSLLLDGQEAFNLSVYDKSLLVSTVLQDTDGQFIGLSVAEDLAFALENDMESQVVMKQKVGDWAERLSLTDLLAHRPQDLSGGQKQRVSLGGVLIDESPILLFDEPLANLDPKSGQDTIDLIDRLHKQEGTTTIIIEHRLEDVLYRQVDRVVLINDGRILFNGGPDDLLRTSLLQENGIREPLYLSTLRALGYPIAQAERLSSVWEIDIEALNIASLPTLHFENGEKEALLEVKHLYFSYPNKQVLTDIQLTIHKGERLAIVGKNGAGKSTLAKVLCGFIQGEGEILWKGQSIKEDSVKERAERIGYVLQNPNQMISQTMIFDEVALGLRMRGVTEEEIEHRVHHILKVCGLYPFRNWPISALSYGQKKRVTIASILVLNPEIILLDEPTAGQDQRHYREMMEFLDQLNAQGHTIVMITHDMQLMLDYSDRAVVVVDGQIIEDASPAEILSDDTVIERANLKETSIFHLAERVGVNPLELTTFYMQEERRGR
>NC_018526.1|WP_011921979.1|388515_389349_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MSQQKLIGYHPGTGLIHSLSAVSKLLFFLIVSILAMITYDTRLILFIAVFSLALFKMSGIRYKEISLVLILTIIFAAMNALMVHLFAPRYGVELYGADTPLLSGLGVYSLTSQQAFYLVNLLLKYFCTVPLAIIFLMTTHPSQFASSLNQIGVSYKVAYAVSLTMRYIPDIQEEFYTIRMSQEARGLELSKKGKLMDRIKGNLSLVIPLIFSSLERIDTISTAMELRRFGKNKKRTWYTQQPLQRIDYAVLLFILALVVVTIYLFFVNQGRFYNPWR
>NC_018526.1|WP_004195223.1|389508_389712_+|cold-shock-protein
MVQGTVKWFNAEKGFGFIAQENGPDVFAHFSEIQSNGFKSLEDGQKVTFEVEQGQRGLQATNITKIG
>NC_018526.1|WP_011921980.1|389753_390467_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MKPEVFYKTLADQGIQLTDQQKHQFHRYFQLLVEWNEKINLTAITEESEVYLKHFYDSIAPLLQGHIQNEPLRLLDIGAGAGFPSLPMKIIFPQLDVTIIDSLNKRINFLHLLAEELELEGVHFYHGRAEDFAQDKNFRAQFDLVTARAVARMQILSELTIPYLKLHGKLIALKASSAEDELTQAKNALNLLFAKVIENHDYTLPNGDPRTLTIVEKKKETPNKFPRKAGMPNKRPL
>NC_018526.1|WP_011921981.1|390525_392712_-|PBP1A-family-penicillin-binding-protein
MVNLLKTTTIKKALLITANILLAGAIIACLAGAALVVYYIQSAPELTEESLTATVSSKIYDKNGNLIADLGAEKRSSAKTEEIPTDLVNAIVAIEDQRFFNHRGVDVIRIAGSLINNLSGGRLQGGSTLDQQFIKLTYFSTSVEDQNLKRKIQEAWLATQLERRNTKQEILTYYINKVYMSNGNYGMKTAALAFYGKELKDLTLPQLALLAGMPQAPNQYDPYTNPEDAKARRDLVLAEMLEEKYIDNTQYEQAVLTPVTDGLQPLSNAAAYPAYMDNYLKQVVEEVEAKTGYNLLTTGMDVYTNVDPAAQQQLWNIYNTDMYVSYPDDLLQVASTVVDVSNGKVVAQLGGRKQETNVSFGTNQAVETNRDFGSTMKPITDYAPAFENGIYTSTADLILDGPYNYPGTPTPVNNWDKQYYGNISVKTAIQYSRNVTAVKALEATGLENALKFLNSVGINYPDIHYSNAISSNTSDTSSKYGASSEKMAAAYAAFANGGTYYAPQYVNKIVFSDGTVTEYAPKGTKVMSAETAYMMTDMMKAVMSYGYGLNASVSGVPMAGKTGTSNYTDSETDTILASIPEANYSYMVVPDENFVGYSSQYAMAVWTGYTNRMTPILDNSMRIATDVYHNMMLFMHSDYTATDWEMPSGLVRYGSNYYLRGSRSLSNAYNTYTSSSTSSSSSTETSETTEATTTSSETSSGTATETATSSTETATTGNNPATGQTDGQ

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Crispr_ID: NC_018526_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018526_4

1615337-1615481

Orphan

Consensus_repeat	Method
GTCCACTCTCGCCGTTGCGCCTTTCCAGTTTCTTGGGCGCAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018526_4

>merge|NC_018526|4|1615337-1615481|CRISPRCasFinder
GTCCACTCTCGCCGTTGCGCCTTTCCAGTTTCTTGGGCGCAAGCTAAAAAGACCCGTCGGGGTCTCAATTCGCTTTCTTATTTTCATGCTCATGAAAAAACAGTCCATTCTCGCCGTTGCGCCTTTCCAGTTTCTTGGGCGCAAG

>NC_018526|4|3|1615337-1615481|CRISPRCasFinder
GTCCACTCTCGCCGTTGCGCCTTTCCAGTTTCTTGGGCGCAAG	CTAAAAAGACCCGTCGGGGTCTCAATTCGCTTTCTTATTTTCATGCTCATGAAAAAACA
GTCCATTCTCGCCGTTGCGCCTTTCCAGTTTCTTGGGCGCAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018526.1\|WP_002939250.1\|1615507_1615747_-\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NC_018526.1\|WP_012027732.1\|1610172_1612998_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_018526.1\|WP_012027722.1\|1602998_1604876_-\|PTS-sugar-transporter-subunit-IIBCA	unknown	unknown	gnl\|CDD\|131051
NC_018526.1\|WP_002937767.1\|1622692_1624081_-\|dihydrolipoamide-acetyltransferase	unknown	unknown	gnl\|CDD\|237001
NC_018526.1\|WP_012027737.1\|1618297_1619287_-\|lipoate--protein-ligase	unknown	unknown	gnl\|CDD\|161920
NC_018526.1\|WP_012027735.1\|1614461_1615118_+\|DUF1129-domain-containing-protein	unknown	unknown	gnl\|CDD\|368981
NC_018526.1\|WP_012775322.1\|1605081_1606536_+\|sucrose-6-phosphate-hydrolase	unknown	unknown	gnl\|CDD\|273554
NC_018526.1\|WP_002942393.1\|1624421_1625417_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NC_018526.1\|WP_014917308.1\|1606516_1607482_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380514
NC_018526.1\|WP_012027739.1\|1620658_1622419_-\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|273568
NC_018526.1\|WP_012027738.1\|1619416_1620607_+\|hypothetical-protein	unknown	unknown	unknown
NC_018526.1\|WP_012775324.1\|1609012_1610074_-\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NC_018526.1\|WP_002942446.1\|1607971_1608364_-\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|377129
NC_018526.1\|WP_002939248.1\|1613501_1614446_+\|magnesium-transporter-CorA-family-protein	unknown	unknown	gnl\|CDD\|213361
NC_018526.1\|WP_012775325.1\|1625703_1626672_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|238958
NC_018526.1\|WP_011922710.1\|1616815_1617979_+\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NC_018526.1\|WP_002942403.1\|1616285_1616576_-\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NC_018526.1\|WP_002938276.1\|1607562_1607982_-\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|234686
NC_018526.1\|WP_012775323.1\|1608391_1608949_-\|elongation-factor-P	unknown	unknown	gnl\|CDD\|234788
NC_018526.1\|WP_002942409.1\|1615779_1616274_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|180915

Protein	Function_ID	Function_description	E-value
NC_018526.1\|WP_002939250.1\|1615507_1615747_-\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	6.68341e-38
NC_018526.1\|WP_012027732.1\|1610172_1612998_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_018526.1\|WP_012027722.1\|1602998_1604876_-\|PTS-sugar-transporter-subunit-IIBCA	gnl\|CDD\|131051	TIGR01996, Includes:_Phosphotransferase_enzyme_IIB_component, PTS system, sucrose-specific IIBC component. This model represents the fused enzyme II B and C components of the sucrose-specific PTS sugar transporter system. Sucrose is converted to sucrose-6-phosphate in the process of translocation into the cell. Some of these transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci, Streptococci, Lactococci, Lactobacilli, etc. which contain their own A domain as a C-terminal fusion. This family is closely related to the trehalose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively).	0
NC_018526.1\|WP_002937767.1\|1622692_1624081_-\|dihydrolipoamide-acetyltransferase	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	5.84394e-162
NC_018526.1\|WP_012027737.1\|1618297_1619287_-\|lipoate--protein-ligase	gnl\|CDD\|161920	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase. One member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus. [Protein fate, Protein modification and repair].	1.69881e-103
NC_018526.1\|WP_012027735.1\|1614461_1615118_+\|DUF1129-domain-containing-protein	gnl\|CDD\|368981	pfam06570, DUF1129, Protein of unknown function (DUF1129). This family consists of several hypothetical bacterial proteins of unknown function.	2.99466e-85
NC_018526.1\|WP_012775322.1\|1605081_1606536_+\|sucrose-6-phosphate-hydrolase	gnl\|CDD\|273554	TIGR01322, Sucrose-6-phosphate_hydrolase, sucrose-6-phosphate hydrolase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_018526.1\|WP_014917308.1\|1606516_1607482_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380514	cd06291, PBP1_Qymf-like, ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs. This group includes the ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus metalliredigens (strain Qymf) and its close homologs. Qymf is a strict anaerobe that could be grown in the presence of borax and its cells are straight rods that produce endospores. This group is a member of the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	1.56273e-104
NC_018526.1\|WP_002942393.1\|1624421_1625417_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	1.50604e-179
NC_018526.1\|WP_012027739.1\|1620658_1622419_-\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|273568	TIGR01350, Dihydrolipoyl_dehydrogenase, dihydrolipoamide dehydrogenase. This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide.	0
NC_018526.1\|WP_012775324.1\|1609012_1610074_-\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	5.90797e-112
NC_018526.1\|WP_002942446.1\|1607971_1608364_-\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|377129	pfam03780, Asp23, Asp23 family, cell envelope-related function. The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed in a sigmaB-dependent manner in Staphylococcus aureus. Following an alkaline shock Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000 per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required to localize Asp23 to the cell membrane. The overall function for the family is thus a cell envelope-related one in Gram-positive bacteria.	1.25433e-34
NC_018526.1\|WP_002939248.1\|1613501_1614446_+\|magnesium-transporter-CorA-family-protein	gnl\|CDD\|213361	cd12827, EcCorA_ZntB-like_u2, uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family. A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.46201e-115
NC_018526.1\|WP_012775325.1\|1625703_1626672_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl\|CDD\|238958	cd02000, TPP_E1_PDC_ADC_BCADC, Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).	7.20442e-147
NC_018526.1\|WP_011922710.1\|1616815_1617979_+\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	1.6445e-28
NC_018526.1\|WP_002942403.1\|1616285_1616576_-\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	1.41522e-37
NC_018526.1\|WP_002938276.1\|1607562_1607982_-\|transcription-antitermination-factor-NusB	gnl\|CDD\|234686	PRK00202, nusB, transcription antitermination factor NusB.	6.30967e-49
NC_018526.1\|WP_012775323.1\|1608391_1608949_-\|elongation-factor-P	gnl\|CDD\|234788	PRK00529, PRK00529, elongation factor P; Validated.	1.37279e-91
NC_018526.1\|WP_002942409.1\|1615779_1616274_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|180915	PRK07275, PRK07275, single-stranded DNA-binding protein; Provisional.	1.03536e-102

>NC_018526.1|WP_012027735.1|1614461_1615118_+|DUF1129-domain-containing-protein
MSFTEINGLTKKNQEFIHIATNQLIKDGKSDSEIKELLEEILPTIIEKQKTGVTARNLYGAPSEWAASKTISEQEKKDQVEYNENPWLMWLDSSLFMLAIIAGINGLMNLFGQGAQYGLLTLFVIGFGVGAGMYLMYHFVYREQIKTGQRPKLLKAIAFLGLATLAWSVVFILAALIPAAFNPVLPPLVTILIGAAAFGARYLLKKKYNIRNAMSPVQ
>NC_018526.1|WP_002939248.1|1613501_1614446_+|magnesium-transporter-CorA-family-protein
MKQIFLSTMTDLEEIQTFEPGAWINLVNPSQSESMEVAEHYKIDIADLRAPLDAEESSRITVEDDYTLILVDVPILEERNNKTYYITIPLGIILTDDAIITTCLEPLPLFEQFIHRRLRNFFTFMKSRFVFQILYRNAQLYLSALRTIDRKSEEIEKQLHEATRNEELIVLMELEKTIVYFKASLKTNERLVKKLASSSRLLRKYEEDEDLLEDTLVETQQAIEMADIYGSILNSMTHAFASIISNNQNTIMKTLALVTIVLSIPTMVFSAYGMNFKDNIIPFNDIPYAFWWIILFAFAISLSLTFYFIRKRWF
>NC_018526.1|WP_012027732.1|1610172_1612998_-|excinuclease-ABC-subunit-UvrA
MQENIVIHGARAHNLKNIDVTIPREKLVVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGNMDKPDVDSIEGLSPAISIDQKTTSRNPRSTVGTATEINDYLRLLYARVGVPYCINGHGAIAASSVEQIVDEVLELPERQRLQILAPIVRKKKGQHKTIFEKIQKDGYVRVRVNGGVYDVSEVPELSKSKAHNIEVVVDRIVIKDGIRSRLFDSIEAALRIADGYVIIDTMDEKEMLFSEYYACPVCGFTVPELEPRLFSFNAPFGSCSDCDGLGMKLEVDTDLIVPDASKTLREGALAPWNPISSNYYPQMLEQAMNHFGVDMDKPFEELTEEEKNLIFNGSDGKEFHFHYENEFGGVRDIDIPFEGLITNINRRYRETNSDYTRTVMKTYMNELTCGTCHGYRLNDQALSVKVGGEQGLHIGQLSDLSVADHLQVIEHLTLSENEATIATPIVKEIKDRLSFLNNVGLNYLTLSRAAGTLSGGESQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLIASLKKMRDLGNTLIVVEHDEDTMREADWLIDIGPGAGVFGGEIVASGTPAQVAKNKKSITGQYLSGKREIPVPLERRVGNGRFLEVTGAKENNLQDVTVRFPLGKFVAVTGVSGSGKSTLVNSILKKAIAQKLNRNSDKPGKFKSISGIEHLDRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNEAKIRGYKKGRFSFNVKGGRCEACSGDGIIKIEMHFLPDVFVPCEVCHGHRYNSETLEVHYKEKNIAQVLDMTVNDAVEFFKHIPKIERKLRTIQDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSLYILDEPTTGLHTEDIAQLLKVLARFVDDGNTVLVIEHNLDVIKTADHIIDMGPEGGVGGGTVVATGTPEEVAENPASFTGQYLKMKLK
>NC_018526.1|WP_012775324.1|1609012_1610074_-|aminopeptidase-P-family-protein
MQKRLEKFEAKLAQSTVDGILVTGQNNIYYLTGFWGTEATVFISGKRRLFVTDSRYTLIAKASVKGFDIIESRFALEEIAKVIKEDGLEKIGFDSEVTYGFYQSLTSIFEGYQLVAMSNFIEDLRMIKDEKEIATIRRACQISDQAFIDVLDFIKPGQTTEMDVNHFLDHRMRQLGAEGASFEFIVASGYRSAMPHGRASEKVIQSGETLTLDFGCYYQHYVSDMTRTIHIGHVTDQEREIYDVVLRANKALIEQAKEGVTYREFDAIPREIISAAGYGANFTHGIGHGIGLDIHEYPYFGKSDETIKAGMVLTDEPGIYLDDKYGVRIEDDLLITENGCEVLTLAPKELIVI
>NC_018526.1|WP_012775323.1|1608391_1608949_-|elongation-factor-P
MIEASKLRAGMTFEAEGKLIKVLDASHHKPGKGNTIMRMKLRDVRTGSTFDTTYRPDEKFEQAIIETVPAQYLYQMDDTAYFMNTETYDQYEIPVATIKEELLYILENSEVKIQFYGTEVIGVTVPTTVELVVAETQPSIKGATVTGSGKPATMETGLVVNVPDFIEAGQKLVINTAEGTYVSRA
>NC_018526.1|WP_002942446.1|1607971_1608364_-|Asp23/Gls24-family-envelope-stress-response-protein
MTTEYQGEIVIAPRVLEVITGIAAAKVDGVHSLQNKRVADSWSKTSLNKGVYLETDEEGRVTADIYVYLEYGVNVPAVSMDIQRAVKTAVYNYAEVQVAAVNIHVSGIVPDKTPKPALKDLFGEDFLDEE
>NC_018526.1|WP_002938276.1|1607562_1607982_-|transcription-antitermination-factor-NusB
MKNNRHALRKCALQAIVSLEFGQEPVQAAQFSYLYDREEEQEGVEIPLFLLNLVNGVADYRDDLDKELSSRLKAGWTLDRLTLIDKNIMRLGLFEILHFEETPDRVAVNEAIELAKEFSDESSAKFVNGVLSQFIKEEA
>NC_018526.1|WP_014917308.1|1606516_1607482_+|LacI-family-DNA-binding-transcriptional-regulator
MVAKLTDVAQLAGVSPTTVSRVINKKGYLSEKTIRNVEEAMRELGYKPNNLARSLQGKSAKLVGLIFPTINNIFYSELISHLEKELFDRGYKTIICNSQHESDKEREYLEMLAANQVDGIISGSHNLGIQDYDRVVAPIIAFDRNLSPSIPIVSSDNFAGGVLAAQTLQKAGCHNPLMITGNDDSNSPTGLRQVGFTSILNKAEVFHISSDFSPVRKEMEIRAILEKQKPDGIFVSGDATAMLVWNIIRSMKLSIPEDIKLIGYDGTSFIENYYPQLTTIKQPLTEIARLLVELLVDKIEGKKLTKTDYILPISLLAGASI
>NC_018526.1|WP_012775322.1|1605081_1606536_+|sucrose-6-phosphate-hydrolase
MAFTTGERYRAYADWTPEYIEKIKKNTESSPWRTNFHIETPHGLLNDPNGFSYFNGKWTLFYQYFPFGAAHGLKSWVHTESTDLVHFEETGTVMYPDTPLDSHGAYSGSAMEFGDKLFLFYTGNVRDENWVRHPYQIGALMDKDGKIEKIDKVLIEQPEDTTDHFRDPQIFNYKGQYYAIVGGQNLDKKGIVKLYKAENNDYLNWSYVGDLDFANDMTAYMMECPNIAFVGEQPILLYCPQGLDKEVLDYGNIYPNMYKIGQSFVPETASIVEPSELINLDYGFECYATQAFNAPDGRTLSVSWLALPDVEYPTDAYDYQGCLSLVKELTIKDGKLYQYPVDAITSLRKEAQPFSAQKETNNVYELELDFSASTKHEIVLFANEAEKGLVLSVDTEQGQITLDRGNCGQPFALDFGTSRSCEISPGALTANIFIDKSVFEIFINKGEKVFSGRVFPDADQSGIVITTGNPTGTYYHLDYGRKTN
>NC_018526.1|WP_012027722.1|1602998_1604876_-|PTS-sugar-transporter-subunit-IIBCA
MNNTEIAKKVIDALGGRENVRSVAHCATRLRVMVVDEGKIDKDTVEDIEKVQGAFFNSGQYQIIFGTGTVNKIYDEVVALGLPTATTGEQKAEAAKQGNAFQRAIRTFGDVFVPIIPAIVATGLFMGLRGLLGALGYTLPEDLNVYSQILTDTAFIVLPALVVWSTFRVFGGNQTIGIVLGMMLIAGQLPNAWVVASGGDVKPTIFFGFIPVVGLQGSVLPAFIIGLVGAKFEKAVRKVVPEVLDLLVTPFVTLFVMSILGLFVIGPVFHVVENYILAGTQAILNLPMGLGGLLIGGVHQVIVVSGVHHIFNFLEAQLVANTGANPFNAIITAAMTAQGAATVAVGVKTKNPKLKALAFPAALSAFLGITEPAIFGVNLRFRKPFLLSLIAGAIGGAVASLLGLAGKGMGVTIIPGATLYVGNGQLFQYILMVAVSFALGFALTYLFGFEDEVEAAPKAAAAPVATPATPAVELNEETLVSPLSGDVVALENVNDPVFSSGAMGKGLAVKPSEGVVYAPADAEVTIAFETGHAYGLKTASGAELLIHIGIDTVSMNGNGFEKLVAAGDKVKAGTPLAKFDAAKIAEAGLDDTTMIIVTNTADFAEVSPLAEGTIAHGVEFLKVAK
>NC_018526.1|WP_002939250.1|1615507_1615747_-|30S-ribosomal-protein-S18
MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFISERGKILPRRVTGTSAKNQRKVTTAIKRARVMALLPFVNED
>NC_018526.1|WP_002942409.1|1615779_1616274_-|single-stranded-DNA-binding-protein
MINNVVLVGRMTRDAELRYTPSNQAVATFTLAVNRNFKNQNGEREADFINVVIWRQQAENLANWAKKGALIGVTGRIQTRSYDNQQGQRVYVTEVVAESFQLLESRTAREGQGGGYSAGNSFAGGNDYNSPYQAPAQSTPNFAREESPFGASNPMDISDDDLPF
>NC_018526.1|WP_002942403.1|1616285_1616576_-|30S-ribosomal-protein-S6
MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATIVESKAWEKRRLAYEIKDFREGLYHIVNVEANNDEALKEFDRLSKINGDILRHMIVKLDA
>NC_018526.1|WP_011922710.1|1616815_1617979_+|IS30-family-transposase
MKNKHLTLSDRNDIQIGIEQLKPFSAIAAKLGKDPSTISKEVRRNRVIKENSSTSNCEACPLLKKTPYVCNACPKKRSNCGYQKQFYYAKRAQLDYEVKLSDSRTGVALNKEEFYRMDEIVSAAIQKGQHLNHIIASNEMSASRASIYRYLEKGYLSTKPIDFPRVVKFRKRRIRNLQPIPKIAKEGRSYEDFQRFLTEKGISYWLEMDTVTGRIGGKVLLTFNLSFCNFIFAQLLDNKTANEVAKHLYAIKNDLHQKEMDFCEIFPVILTDNGGEFARVDDIEMDVRGESKLFFCDPNRSDQKGRIEKNHTLIRDILPKRSSFDNLTQEDINLVCSHINSVKRASFNGKSAYELFTFTYGEELATLLGISKIDPENVIQSPRLLDK
>NC_018526.1|WP_012027737.1|1618297_1619287_-|lipoate--protein-ligase
MKYIVNNSNDPAYNIALEAYAFKELTDIDEIFILWINEPAIIIGKHQNAIEEINKEFTDEKGIHVVRRLSGGGAVYHDLNNLNYTIISNKADEGAFDFKTFSKPVIDTLATLGVEANFTGRNDLEIDGKKICGNAQAYAKGRMMHHGCLLFDVDMSVLASALKVSKDKIESKGVKSVRARVTNINNELPDKMTVLEFKDAILNQMKQEYPEMDEYVLTEDDLARIQEIRDSQFATWDWTYGQTPEYTVERSVRYPAGKITTYIKAEKSVIESIKIYGDFFGIGDVADVEDLLVGTRYEYADVLAKLQEIDTTHYFSRMTTEEVAKAIVA
>NC_018526.1|WP_012027738.1|1619416_1620607_+|hypothetical-protein
MSKHLKSFLIFYLAASIFLPFMWFINAPLICFVLPLYLTWKNIRHFWDLLKKQLKEYSFWINDGLIFFLGTGLSWLALEMAQVVYVDWPETLVNNQIHSPMQTEAWSGQFFLLLLGVLAYLVLNIFQTKLLPPLLTVLLISCLYPSFVFAVLWTIQLSSLIETDFFTYCYLCLVPFNICLIYSRTILQTIQLWQAELAKQSNPRFPRLSALLQKSLSLPIWLLFFSLPYLAVLGSYLILFGQKPDQLLQMWTETSDWALSEKISPPNAFYDEHYLCTVGAAGHRKLVKPIRMGERHGHRVVVNRQLQIANAFEQILEERCPRLHRCVRSNYDRYGYPISKHIRKAWQADLIYLIMKPAEWLFLIVIYLHDRQPENRIAVQYLPLSKNLLPQENTSN
>NC_018526.1|WP_012027739.1|1620658_1622419_-|dihydrolipoyl-dehydrogenase
MAIEIIMPKLGVDMQEGEIIEWKKQEGDFVNEGDVILEMMSDKTSMELEAEESGVLLKIVHGNGATVPVTEVIAYLGAEGESVEVGAALAPAEVAQATADLKAAGLEVPATPAAAPQAPKAELAADEYDMVVVGGGPAGYYAAIRGAQLGGKIAIVEKSEFGGTCLNKGCIPTKTYLKNAEILDGLKIAAERGINLASTNYTVDMDKTVDFKNKVVKTLTGGVQGLLKANKVTIFNGLGQVNPDKTVVIGDKVIKGRSIILATGSKVSRINIPGIDSKLVLTSDDILDLREIPKSLTVMGGGVVGVELGLVYASYGTEVTVVEMADRIIPGMDREVSVELQKVLSKKGMKFLTSVGVSEIVEANNQLTIKLNDGSEIVSEKALLSIGRVPQLAGLENLNLELDRGRIKVNEYQETSIPGIYAPGDVNGTKMLAHAAYRMGEVAAENAIHGNHHKAKLDFTPAAVYTHPEIAMVGLTEDQAIEKYGKENILIGRNSFTGNGRAIASNEAHGFVKVIADKKYHEILGVHIIGPVAAEMINEAATIMESELTVDDVAASIHGHPTFSEVMYEAFLDVLGVAIHNPPKRK
>NC_018526.1|WP_002937767.1|1622692_1624081_-|dihydrolipoamide-acetyltransferase
MAIEIIMPKLGVDMQEGEIIEWKKQEGDFVNEGDVILEMMSDKTSMELEAEESGVLLKIVHGNGATVPVTEVIAYIGAEGETVEAGASSAPAVEPAAAIEEVPAGRTPVIVAPATAAKPQGSGKVRATPAARKLARELGIDLGLVPGTGANGRVHKVDVEDFKGAAPKATPLAARIAADQGVDLSTLTGSGVNGKIVKNDVLAVLAPVAVETAAPVPKAEEKPAKELPEGVEIIKMSPMRKAISKGMVNSYLTAPTFTLNYDIDMTNLMALRKQVLEPIMNKTGLKVTFTDLIGLAVVRTLMKEEHRYMNASLINDAQEIELHKFVNLGIAVGLDDGLVVPVVHGADKMSLSDFVVASKDVIKKAQSGKLKGAEMSGSTFSITNLGMFGTKTFNPIINQPNSAILGVASTVQTPVVIDGEIKIRPIMALCLTIDHRIIDGMNGAKFMVDLKNLLENPLELLI
>NC_018526.1|WP_002942393.1|1624421_1625417_-|alpha-ketoacid-dehydrogenase-subunit-beta
MAETKVMALREAINLAQSEEMRKDEKVFLMGEDVGIYGGDFGTSVGMLDEFGPKRVRDTPISEAAIAGSAVGAAQTGLRPIVDLTFMDFITIALDAIVNQAAKTNYMFGGGLKTPVTFRVASGSGIGSAAQHSQSLEAWLTHIPGIKVVAPGTANDAKGLLKSSILDNNPVIFLEPKALYGKKEEVNLDPDFYIPLGKGEIKREGTDVTIISYGRMLERALKAAEEVAAEGISVEVVDPRTLIPLDKELIIESVKKTGKVILVNDAYKTGGFIGEIASIITESEAFDYLDAPIIRIASDDVPVPYANILENAVLPNVEKIKAAIYKQVNKG
>NC_018526.1|WP_012775325.1|1625703_1626672_-|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MVSITKEQHLDMFLKMQQIRDVDMKLNKLVRRGFVQGMTHFSVGEEAAAVGPIAGLTDEDIIFSHHRGHGHVIAKGIDINGMMAELAGKATGTSKGRGGSMHLANVEKGNFGSNGIVGGGYALAVGAALTQQYLGTDNIVIAFSGDSATNEGSFHESMNLAAVWNLPVIFFITNNRYGISTDISYSTKIPHLYQRAAAYGIPGHYVEDGNDVIAVYEKMQEVIEYVRAGKGPAMVEVESYRWFGHSTADAGVYRTKEEVNEWKAKDPLKKYRKYLTENKIATDEELDAIEAQVAEQVEASVKFAQESPDPDISVAYEDVFVD

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Crispr_ID: NC_018526_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018526_5

1659669-1659792

Orphan

Consensus_repeat	Method
CCAATCAACCACTACTGCGCTAAGATGTTGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_018526_5

>merge|NC_018526|5|1659669-1659792|CRISPRCasFinder
CCAATCAACCACTACTGCGCTAAGATGTTGACACTAACGTTGAGAAGCGGTACAGGGCTTGAGCCCAGCTTCACTCCACTGGACTGTTAAACCCAATCAACCACTACTGCGCTGAGATGTTGAC

>NC_018526|5|4|1659669-1659792|CRISPRCasFinder
CCAATCAACCACTACTGCGCTAAGATGTTGAC	ACTAACGTTGAGAAGCGGTACAGGGCTTGAGCCCAGCTTCACTCCACTGGACTGTTAAAC
CCAATCAACCACTACTGCGCTGAGATGTTGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_018526.1\|WP_012027774.1\|1665668_1666571_-\|SPFH-domain-containing-protein	unknown	unknown	gnl\|CDD\|259805
NC_018526.1\|WP_012027766.1\|1656133_1657357_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NC_018526.1\|WP_012775334.1\|1661134_1661857_-\|adaptor-protein-MecA	unknown	unknown	gnl\|CDD\|235030
NC_018526.1\|WP_012775333.1\|1657360_1658623_-\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NC_018526.1\|WP_002938151.1\|1653941_1655357_-\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NC_018526.1\|WP_009910800.1\|1665373_1665583_-\|hypothetical-protein	unknown	unknown	unknown
NC_018526.1\|WP_014917310.1\|1650443_1652234_-\|oligopeptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173875
NC_018526.1\|WP_009910803.1\|1668113_1669136_-\|ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235491
NC_018526.1\|WP_012775335.1\|1664505_1665249_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_018526.1\|WP_014917311.1\|1652446_1653697_+\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NC_018526.1\|WP_012775691.1\|1655706_1656147_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918
NC_018526.1\|WP_012028491.1\|1662947_1664513_+\|ABC-transporter-substrate-binding-protein/permease	unknown	unknown	gnl\|CDD\|270345
NC_018526.1\|WP_002942324.1\|1649059_1650058_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_018526.1\|WP_012027769.1\|1659965_1661138_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NC_018526.1\|WP_002938143.1\|1647157_1648114_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_018526.1\|WP_002937416.1\|1666580_1667831_-\|threonine-ammonia-lyase-IlvA	unknown	unknown	gnl\|CDD\|236318
NC_018526.1\|WP_012027759.1\|1648115_1649057_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NC_018526.1\|WP_012027770.1\|1661984_1662821_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712
NC_018526.1\|WP_002938165.1\|1658639_1659413_-\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NC_018526.1\|WP_009910805.1\|1669276_1669753_-\|acetolactate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|183365

Protein	Function_ID	Function_description	E-value
NC_018526.1\|WP_012027774.1\|1665668_1666571_-\|SPFH-domain-containing-protein	gnl\|CDD\|259805	cd03407, SPFH_like_u4, Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.	3.71678e-128
NC_018526.1\|WP_012027766.1\|1656133_1657357_-\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NC_018526.1\|WP_012775334.1\|1661134_1661857_-\|adaptor-protein-MecA	gnl\|CDD\|235030	PRK02315, PRK02315, adaptor protein MecA.	2.58092e-83
NC_018526.1\|WP_012775333.1\|1657360_1658623_-\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	4.97321e-124
NC_018526.1\|WP_002938151.1\|1653941_1655357_-\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NC_018526.1\|WP_014917310.1\|1650443_1652234_-\|oligopeptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173875	cd08510, PBP2_Lactococcal_OppA_like, The substrate binding component of an ABC-type lactococcal OppA-like transport system contains. This family represents the substrate binding domain of an ATP-binding cassette (ABC)-type oligopeptide import system from Lactococcus lactis and other gram-positive bacteria, as well as its closet homologs from gram-negative bacteria. Oligopeptide-binding protein (OppA) from Lactococcus lactis can bind peptides of length from 4 to at least 35 residues without sequence preference. The oligopeptide import system OppABCDEF is consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and also is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_018526.1\|WP_009910803.1\|1668113_1669136_-\|ketol-acid-reductoisomerase	gnl\|CDD\|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NC_018526.1\|WP_012775335.1\|1664505_1665249_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	7.30548e-147
NC_018526.1\|WP_014917311.1\|1652446_1653697_+\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	1.78392e-90
NC_018526.1\|WP_012775691.1\|1655706_1656147_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.35279e-67
NC_018526.1\|WP_012028491.1\|1662947_1664513_+\|ABC-transporter-substrate-binding-protein/permease	gnl\|CDD\|270345	cd13627, PBP2_AA_binding_like_2, Substrate-binding domain of putative amino acid-binding protein; the type 2 periplasmic-binding protein fold. This putative amino acid-binding protein belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.18368e-91
NC_018526.1\|WP_002942324.1\|1649059_1650058_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.71068e-159
NC_018526.1\|WP_012027769.1\|1659965_1661138_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	9.66017e-81
NC_018526.1\|WP_002938143.1\|1647157_1648114_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.06681e-112
NC_018526.1\|WP_002937416.1\|1666580_1667831_-\|threonine-ammonia-lyase-IlvA	gnl\|CDD\|236318	PRK08639, PRK08639, threonine dehydratase; Validated.	0
NC_018526.1\|WP_012027759.1\|1648115_1649057_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	2.10004e-119
NC_018526.1\|WP_012027770.1\|1661984_1662821_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	1.49616e-101
NC_018526.1\|WP_002938165.1\|1658639_1659413_-\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	2.74827e-148
NC_018526.1\|WP_009910805.1\|1669276_1669753_-\|acetolactate-synthase-small-subunit	gnl\|CDD\|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	1.6123e-73

>NC_018526.1|WP_002938165.1|1658639_1659413_-|Fe-S-cluster-assembly-ATPase-SufC
MSVLEIKDLHVEIEGKEILKGVNLTLKTGEIAAIMGPNGTGKSTLSAAIMGNPSYEVTQGEILFDGVNILELEVDERARMGLFLAMQYPSEIPGITNAEFLRAAMNAGKEDEDKISVRDFITKLDEKMELLNMKEEMAERYLNEGFSGGEKKRNEILQLLMLEPTFALLDEIDSGLDIDALKVVSKGINAMRGEGFGAMIITHYQRLLNYITPDVVHVMMEGRVVLSGGPELAQRLEKEGYVQVAAELGIDYKEDDI
>NC_018526.1|WP_012775333.1|1657360_1658623_-|Fe-S-cluster-assembly-protein-SufD
MTKEKIQEFSALQAEPTWLTDLRLKAFDKIAELDLPVIERVKFHRWNLGDGSLATNDEIGAVPDFTAIGDNPMLVQVGSQTILEQLPVALVEKGVVFTDFASAMDVIPDVLEKYLGAAVAYDEHKLAAYNTAYFNATAVLYVPDNVEIDQPVEALFYQDSTSPVAFNKRVLIIAGKNAKLNYLERFESLGDGAATTSANIVVEVIALAGSQIKFAAIDRLGKHLDTYLNRRGYLGNDATIDWAIGLLNEGNVVADLDSELKGNGSHANLKVVGLSSGRQVQGVDTRVTNYGHNSVGHILQHGVILESGTLTFNGIGHIVRGAKGADAQQESRVLMLSDKARSDANPILLIDENEVTAGHAASIGQVDPEDMYYLMSRGLDRATAERLVVRGFLGSVITEIPVKEVRDQLIAVIEEKLTKR
>NC_018526.1|WP_012027766.1|1656133_1657357_-|cysteine-desulfurase
MDLERIRKEFSILDQVVNDEPLVYLDNAATTQKPQQVLDVLADYYQKDNANVHRGVHTLSERATTRYEAARQKVADFIQAKSSKEILFTRGTTTSLNWVAQFAKEILQPDQEVIISVQEHHSNIIPWQQACQQTGAKLRYVTLKDGELDMDHLRSLLSSKTKFVSLAHVSNVLGGVVPIGEIAELVHQVGAYLVVDGAQSVPHMGVNVQELDVDFYAFSGHKMLGPTGIGILYGKEELLNLMSPVEFGGEMIDFVYEQSATWKELPWKFEAGTPNIAGAIGLGAAIDYLTEIGMDAIQAHEAELVDYVFPKLQAIPGLTIYGSQDLSKRTGVIAFNLDDLHPHDVATALDYEGVAVRAGHHCAQPLLRYLQVPATVRASFYIYNTKADCDKLVEAIIKTKEFFNGPI
>NC_018526.1|WP_012775691.1|1655706_1656147_-|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MALSRLDSLYMAVVSEHSKSPRHRGSLDGVEKLELHNPTCGDVIELSVKIEKDVITDIAFDGVGCTISTASASMMTEAVLGKEISQIQELAEIFSQMVRGQEDPRQKELGDASLLAGVAKFPQRIKCATLPWNALKKALERSDSAE
>NC_018526.1|WP_002938151.1|1653941_1655357_-|Fe-S-cluster-assembly-protein-SufB
MSEERIEPTPIDLGEYKFGFHDENVELVASTGKGLNEEVIREMSRIKGEPEWMLEFRLKSYETFKKMPMQTWGADLSELDFDDIVYYQKPSDKPARSWDDVPDKIKETFERIGIPEAERAYLAGASAQYESEVVYHNMKEEYDKHGIIFTDTDTALKEHPELFKKYFGKLVPPSDNKLAALNSAVWSGGTFIYVPKGVKLDIPLQTYFRINNEGTGQFERTLIIVDEGASVHYVEGCTAPTYSTASLHAAIVEIIAHEGAYMRYTTIQNWSDNVYNLVTKRARAEKNATVEWIDGNLGAKTTMKYPAVYLEGEGARGTMLSIAFANKGQVQDTGAKMIHNAPRTSSSIVSKSIARGGGEVNYRGQVTFAKNSAKSISHIECDTIIMDDISKSDTIPFNEIHNSQVALEHEAKVSKISEEQLYYLMSRGLSESEATEMIVMGFVEPFTKELPMEYAVELNRLIAYEMEGSVG
>NC_018526.1|WP_014917311.1|1652446_1653697_+|D-alanyl-D-alanine-carboxypeptidase
MRKLLLTLTTILAVFLTSTPILAEDFSVAAKHAIAVEVSSGKILYEQDAETKASIASISKTLSIYLVYEALAKGEITLDTMVDISDYPYSLTSNTELSNVNLDERSYSVRDLLNASLITSSNSAIIALAEKIAGSEAAFVDRMKAKVQEWGITDTKIVNVSGLDNTDLGENIYPGSSPEDVNMFSALDVAIIARRLILDYPQVLDITSLNAYDFGGYTYYSTNQMLSDGTHARGGVDGLKTGTSNSAGSSFLATTQQAGMRIITVVLNANDGLTSPENRFVATNDLMNYVYSNFSLVTLVKKSEAFGDSKIKVFNGEKETSPVVAAADLTVVQRNQTDNVPTATFTTDIKEIDAPLKAGTLVSKLQLKDQDLIGKGYISEQTGVDMIIPSDMKEASWPFSWWNQFVRYVNEKIIKK
>NC_018526.1|WP_014917310.1|1650443_1652234_-|oligopeptide-ABC-transporter-substrate-binding-protein
MKKTTKLFALAGVTLLSASVLAACGSKQSGAAKQELSFPAEVKQDGTAVADAQLKYAWVSPTTSSGLLIDELTENTTDSTFGGMVDISMFGYDGERKLDDSGLAKAEFDVKGKKITVSLTGKDYKWSDGEPFTINDYIFTIKSMASKDYTGIRFDDKFLNIEGMQEFVDGKASDISGIKKVDDYTVELTVKEMSPSMMYAGGDVPAYIQPEHIYKDIPVADWEKSEYSRTAKLVGMGPWKIKEIVNGESITYVPNEYFFKGTKPKTSSLKIDIVSPDTIVSEMKAGNYDIAEMPVDQLDSYKDASNLNIVGQLESSYEYISFNFGKYDEAAGKNVMDENAKMNDVKLRQAIAYAIDTKTAGKSLYNGLYHPAKSLIISFFGDIHDSELEGYSYNPEKAKKLLDEAGYKDVDGDGIREGKDGKAFKITFAARKRTEANEALVQQYIAWWKEVGLNVELYTGRIVEGKSFYNSVQANDAAIDMYAGGWSTGYDPNPSGLWGPIAAFNMSRFVSDENTKLLEAISSAESFDDKKNVENYKAWQKYAHEQAFAIPTFESEKITAVNKRVKSYDTKYGSASGTGLAYEGIELTADKGVVAE
>NC_018526.1|WP_002942324.1|1649059_1650058_-|ABC-transporter-ATP-binding-protein
MATEKPLLDIKDLHVGFRIGDDYFDAVDGVDISLQKNEILAIVGESGCGKSTLATTIMGLHNPLNTKITGSIQYNDMELIGMDEAKYNTVRGNDIGMIFQDPLASLNPLMTIGAQIDEALFYHTDLDANARTERVLELLAQVGIPNPKRTFKQYPHELSGGMRQRIIIAMALSCKPPIIIADEPTTALDVTIQAQILDLLNDIQAETGSGIILITHDLGVVAETADRVAVMYGGQFVEVAPVEELFTNPKHPYTRSLLKSNPQSGSEGGDLHVIEGIVPPITKMVRKGCRFAPRIPWIGAEAHEENPSMHEVGPNHFVRCTCHETFYFEGEA
>NC_018526.1|WP_012027759.1|1648115_1649057_-|ABC-transporter-ATP-binding-protein
MGFIEVKDLKVHYPIRSGFFNRVTDHVYAVDGVNIEFEEGKTYGLVGESGSGKSTIGKAIIGLERATSGQIIYEGQDVTNKSRGKKGNFNRDVQMIFQDSLSSFNPKKRILDIIAEPIRNFDRLSPDEEKKKVLQLLDTIGLNEEALIKYPHEFSGGQRQRIGVARALASNPRLIIADEPVSALDLSVQAQVLNYMKRIQDEFKLSYLFISHDLGVVQHMCDELFIMYRGRFVETGNKNDIYNNPQHIYTKRLLSAIPTIDPLNRLKNKEKRLAAEKEYQEMQGQYYDENGRVYDLRSFSETHQVALPEGGQN
>NC_018526.1|WP_002938143.1|1647157_1648114_-|ABC-transporter-permease
MWKTVLRRLLMMIPQIIILSVIAFFVAKMMPGDPFTGLIDPNIDPAIIEQKRIAAGYYDPIPVQYFRWVGNLLQGDFGQSVIFKQPVVDVIMQRLNNTIGLSLLTMVLTYLIALPLGMIAGRYQNSLADKIIGVYNFLTFSTPTFVFAILMLWMFGFSLGWFPTRGSISGGVEGFAATLSRLHHMILPAITMAILSTTVTIQYLRTGIIDAKSQDYVRTARAKGVPERVVYNRHIFRNSILPIASFLGYELTGLIGGSIFIENIFTYPGIGQLFFNSISSRDYSVILALLLVFGMGTLLGTLISDIIMSIVDPRIRVK
>NC_018526.1|WP_012027769.1|1659965_1661138_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MIPFALKYIMVIITTMVISAIATPLVRFMSLRVGAVDNPNARRINKVPMPSAGGLAIFVAFTISVLWFLPGIVTRVNYHGTYLHYIWPLVLASSIIVLTGFIDDVKELKPAPKMFGILAAATIIWIFTEFRFDSFKIPFGGPFLQFPVWLSFLLTVLWIVSITNAVNLIDGLDGLVSGVSIISLTTMGIVSYFFLHDSNIFLTLTIFVLVAAIVGFLPYNYNPAIIYLGDTGALFIGFMIGVLSLQGLKNSTAVAVVTPMIILGVPITDTVVAIIRRKLSGQKIYEADKMHLHHRLLSLGLTHRGTVLVIYAISFLFSLTSLLLNVSSRIGGILLLVTMGLGIEILCELIGIFGINRTPLLNLLRFIGNSSYRQEKIAKYKKCCEEKKRK
>NC_018526.1|WP_012775334.1|1661134_1661857_-|adaptor-protein-MecA
MKVKQISDSTLKITIKLDDLEERGMELSDFLIPQEKTEEFFYTVLDELDLPMTFRESGMLSFRVTPKPDRVDIFVTKSDLDQNLNFDEFTDLSELGDVASMTPDEFFKSLEQTVREKSAPDATAVRHLEEVEQEEEADEEEQERYIYYILEFPTIEDLFTFVGTVDYPVEESELYKMDGHYYLTVLINVENRSKQYPGYILSRMLEFTNDTKLTRPALQEHGTLMLPLAAIEELRKVPTV
>NC_018526.1|WP_012027770.1|1661984_1662821_-|undecaprenyl-diphosphate-phosphatase
MLLELLKAIFLGIIEGVTEWLPVSSTGHLILVQEFVKLNQSKNFLEMFNIVIQLGAILAVMTIYFKKLNPFQPGKTKRDIQLTWQLWAKVVIACIPSILIAVPLDNWFEAHFNFMVPIAIALIVYGIAFIWIENRNRGIEPQVTDLAKMSYKTALLIGCFQVLSIVPGTSRSGATILGAIILGTSRSVAADFTFFLGIPTMFGYSGLKAVKYFLDGNSLNMEQVWILLVASVTAYLVSLVVIRFLTDFVKKHDFTVFGYYRIILGAILLVYAFITFLF
>NC_018526.1|WP_012028491.1|1662947_1664513_+|ABC-transporter-substrate-binding-protein/permease
MKRKLSIFLLTLIAVFSVTTGVRADEYLRVGMEAAYAPFNWTQEDDSNSAVPIEGTNQFANGYDVQVAKKIAASMDKELLVVKTKWEGLVPALTSGKIDMIIAGMSPTEERKKEIAFSDSYYTSIPTLVVRSDSQYANATSLEDFAGAKITAQQGVYLYDLIDQIEGANKQTAMGDFSQIRQALESGIIDAYVSERPEGRTAEAANKAFKMVELADSFETNAEDVTIAVGMRKDDERIAQVNEVLATISEEEQIALMDDMIENQPVEEASEGETPSFFAQVWNIVVNNWQQLLRGTGMTLLISILGTIIGTAIGLLIGVFRTAPKAANKALAIGQKVLGWIINIYIEIFRGTPMIVQSMVIYYGTAQAFGLNLDRTLAAIFIVSINTGAYMSEIVRGGIFAVDKGQFEAATALGFTHNQTMRKIVLPQVIRNILPATGNEFVINIKDTSVLNVISVVELYFSGNTVATQTYQYFQTFTVIAIIYFILTFTVTRILRAVEKYFDTDTYTTGANQMQVEVPHD
>NC_018526.1|WP_012775335.1|1664505_1665249_+|amino-acid-ABC-transporter-ATP-binding-protein
MTKNVILEIKNLKKSYGQNQVLKDISISVEKGEVISIIGSSGSGKSTFLRSINLLETPTEGQILYHGQDVLAKGYDLTTYREKLGMVFQSFNLFNNLNVLENAIVAQTTVLKRDRAEAEKIAKENLNKVGMTEQYWQAKPSQLSGGQKQRVAIARALSVDPEVILFDEPTSALDPEMVGEVLKTMQDLAKSGLTMLIVTHEMEFARDVSDRVIFMDKGVIAEEGSPQQIFENPQEERTREFLQRFLG
>NC_018526.1|WP_009910800.1|1665373_1665583_-|hypothetical-protein
MTSYEKVAAVVGWVREKKITGYRISKETNAREMSVIALAQGRAKIDNISFATALGLIDFYDKNHKKFEN
>NC_018526.1|WP_012027774.1|1665668_1666571_-|SPFH-domain-containing-protein
MVFGPIVFIGSFLFFVLIALILIASGLYVVKQQTVAIIERFGKYQKTSTSGINFKIPFGVDVIAARIQLRMLQSEIVVETKTQDNVFVTMNVATQYRVNENNVTDAYYKLMHPEAQIKSYIEDALRSSVPKLTLDELFEKKDEIALEVQKQVAEEMSTYGYVIVKTLITKVEPDAEVKQSMNEINAAQRKRVAAQELAEADKIKIVTAAEAEAEKDRLHGVGIAQQRKAIVDGLADSIRELKESNVSLSEEQIMSILLTNQYLDTLNNFAQGGNQTIFLPGNPEGVEDIRTQILSSLRAK
>NC_018526.1|WP_002937416.1|1666580_1667831_-|threonine-ammonia-lyase-IlvA
MITAKNVEQAYSVLKRVVVRTPLDYSRYLSEKYGATIYLKRENEQRVRSFKIRGAYYAISQLTDDEKSRGVVCASAGNHAQGVAYTCQEMQIPATIFMPITTPQQKIGQVKFFGGDYVEIRLVGDTFDESAKAAQDYTQESGKTFIDPFDDENVQAGQGTVAYEILEEAEEQTISFDQILVPIGGGGLVAGVSAYLKEHAPEIKIVGVEASGARSMKAAFDKGRPVKLDQIDKFADGIAVQKVGKSTYEVARKYVDRLIGVDEGWISGTILDLYSKLGIVAEPAGAATIAALEVVKDQIKGQTICCIISGGNNDINRMPEMEERALIYEGIKHYFVVNFPQRPGALREFVNDILGPNDDITRFEYIKRANKGTGPVLIGIALGDKTDYTQFISRLEEFDPQYINLHENDSLYKMLV
>NC_018526.1|WP_009910803.1|1668113_1669136_-|ketol-acid-reductoisomerase
MTVTMQYEKDVTVAALDGKRIAVIGYGSQGHAHAQNLRDTGHDVIIGVRAGKSFDKAKEDGFETFEVAEAAKQADVIMILAPDEIQADLYNEEIAPNLEAGNALGFAHGFNVHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKHIAMDWAKGVGSARVGLLETTFKEETEEDLFGEQAVLCGGLTALMQAGFEVLTEAGYAPELAYFEVLHEMKLIVDLVYEGGFKKMRQSISNTAEFGDYVSGPRVITDQVKENMKAVLADIQSGKFANDFVNDYKAGRPRMEAYRKEAENLEIEKVGAELRKAMPFVGRNDDDAFKIYN
>NC_018526.1|WP_009910805.1|1669276_1669753_-|acetolactate-synthase-small-subunit
MRRMLTAKLRNSSGVLNRFTGVLSRRQINIESISVGPTEVDGISRVTVIVDVVSHDEVEQIIKQLNRLIDVVRVRDLTDIPHLEREVILVKISAPPTKRAEILAIIQPFRANVVDVAPHSITIQMTGDGDKIDALLRVIQPYGIKNIARTGATGFSRD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

31431 : 41693

Microbacterium_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012774881.1\|31431_35151_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	8.6e-39	26.9
WP_011921648.1\|35153_36608_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.2e-58	35.4
WP_012774882.1\|36663_37686_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A127KMF9	Cyanophage	1.3e-58	42.7
WP_011922533.1\|37682_38234_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.6e-26	38.5
WP_011921652.1\|38243_39791_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	2.6e-74	47.6
WP_014917169.1\|39916_41179_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_011921654.1\|41204_41693_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.7e-17	45.0

DBSCAN-SWA_2

536802 : 549915

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011922101.1\|536802_537441_-	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	1.0e-125	99.5
WP_011922102.1\|537503_540017_+	bifunctional DnaQ family exonuclease/ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	0.0e+00	98.5
WP_011922103.1\|540176_541253_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	1.5e-193	99.2
WP_011922104.1\|541317_542556_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.0e-217	96.8
WP_011922105.1\|542565_543351_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.0e-130	95.4
WP_011922106.1\|543373_543778_-	TetR/AcrR family transcriptional regulator	A0A1X9I6A2	Streptococcus_phage	3.2e-64	99.3
WP_002938910.1\|543904_544756_+	DegV family protein	A0A1X9I5J4	Streptococcus_phage	1.3e-152	98.6
WP_011922108.1\|544854_546114_-	PLP-dependent aminotransferase family protein	A0A1X9I5H2	Streptococcus_phage	1.2e-239	98.8
WP_012775019.1\|546236_546971_+	peroxide stress protein YaaA	A0A1X9I5I0	Streptococcus_phage	1.5e-120	99.5
WP_012775020.1\|547075_548521_+	LCP family protein	A0A1X9I5X1	Streptococcus_phage	2.4e-226	99.5
WP_011922111.1\|548538_549228_+	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	1.3e-110	96.1
WP_012775429.1\|549237_549915_+	tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	8.1e-121	99.1

DBSCAN-SWA_3

632455 : 647800

Streptococcus_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012775040.1\|632455_634693_+	DNA internalization-related competence protein ComEC/Rec2	M1PSD2	Streptococcus_phage	1.2e-99	96.7
WP_002935351.1\|634694_634838_+\|transposase	transposase	NA	NA	NA	NA
WP_011922763.1\|635017_635674_+	CBS domain-containing protein	M1NSC5	Streptococcus_phage	2.7e-113	98.6
WP_011922194.1\|635767_636595_+	hypothetical protein	M1PFV6	Streptococcus_phage	1.0e-133	98.5
WP_012775639.1\|636600_637872_+	toxic anion resistance protein	M1PLC8	Streptococcus_phage	3.3e-208	98.3
WP_002935357.1\|637908_638775_-	YitT family protein	M1Q1P6	Streptococcus_phage	4.6e-153	99.7
WP_012775041.1\|638949_639588_+	dTMP kinase	M1PSC7	Streptococcus_phage	1.0e-112	98.1
WP_012775638.1\|639584_640469_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	4.3e-154	99.0
WP_002935361.1\|640488_640806_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	3.1e-54	100.0
WP_002935362.1\|640807_641671_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	2.1e-158	99.7
WP_011922200.1\|642140_643232_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	2.4e-207	100.0
WP_011922201.1\|643231_643789_+	GNAT family acetyltransferase	M1PSC3	Streptococcus_phage	5.9e-93	94.6
WP_011922202.1\|643842_645024_+	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	7.8e-220	99.7
WP_011922203.1\|645026_645533_+	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	7.0e-93	97.0
WP_002935368.1\|645516_645870_+	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.9e-60	100.0
WP_011922204.1\|645886_646786_-	cation transporter	M1Q1N9	Streptococcus_phage	5.1e-163	99.7
WP_012775042.1\|646972_647800_-	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	2.9e-152	100.0

DBSCAN-SWA_4

808168 : 815198

Bacillus_phage(33.33%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011922359.1\|808168_809008_+	thymidylate synthase	U5J9N5	Bacillus_phage	1.7e-88	55.7
WP_011922360.1\|809293_809806_+	dihydrofolate reductase	A0A076GDN3	Bacillus_phage	1.6e-20	36.6
WP_002934974.1\|810003_811230_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.2e-133	59.2
WP_012775089.1\|811285_811873_+	YihA family ribosome biogenesis GTP-binding protein	NA	NA	NA	NA
WP_012028095.1\|811895_812309_+	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	4.3e-24	42.5
WP_012775626.1\|812412_813084_+	membrane protein	A0A1S5SAM6	Streptococcus_phage	3.0e-06	35.2
WP_002943192.1\|813365_815198_+	elongation factor 4	A0A2K9L2P9	Tupanvirus	2.2e-19	38.8

DBSCAN-SWA_5

1192635 : 1198416

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012027298.1\|1192635_1193385_-	ABC-F family ATP-binding cassette domain-containing protein	A0A1B0RXA0	Streptococcus_phage	3.4e-27	32.9
WP_012027299.1\|1193547_1194090_-	ATP-binding cassette domain-containing protein	A0A2I4R674	Erysipelothrix_phage	5.9e-21	35.1
WP_014735627.1\|1194076_1194349_-	hypothetical protein	NA	NA	NA	NA
WP_012027300.1\|1194604_1195408_-	MBL fold metallo-hydrolase	A0A0C5AJ83	Bacteriophage	2.8e-35	35.6
WP_012027301.1\|1195414_1196764_-	cell wall metabolism sensor histidine kinase VicK	W8CYF6	Bacillus_phage	2.1e-35	34.5
WP_004298854.1\|1196756_1197461_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.1e-38	39.8
WP_012027304.1\|1197654_1198416_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.0e-34	38.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_018526

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection