CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_018607	Brachyspira pilosicoli B2904, complete sequence	4 crisprs	DinG,csa3	0	2	1	0

1. NC_018607

CRISPR-Cas detection and classification

Crispr_ID: NC_018607_1

• CRISPR_ID: NC_018607_1
• CRISPR_location: 154888-154964
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_018607_1

Consensus_repeat	Method
ATTACAGACACAAATAAAAATAATAT	CRISPRCasFinder

spacers of NC_018607_1

>1.1|154914|25|NC_018607|CRISPRCasFinder
TCTTCTTAATGCTGATGGAATAAGT

CRISPR arrays and Neighbor proteins around NC_018607_1

CRISPR arrays

The CRISPR arrays of NC_018607_1

>merge|NC_018607|1|154888-154964|CRISPRCasFinder
ATTACAGACACAAATAAAAATAATATTCTTCTTAATGCTGATGGAATAAGTATTACAGACACAAATAAAAATAATAT

>NC_018607|1|1|154888-154964|CRISPRCasFinder
ATTACAGACACAAATAAAAATAATAT	TCTTCTTAATGCTGATGGAATAAGT
ATTACAGACACAAATAAAAATAATAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_018607.1|WP_014935150.1|158924_159521_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935139.1|150819_151911_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935154.1|160556_160766_-|hypothetical-protein	unknown	unknown	gnl|CDD|225288
NC_018607.1|WP_014935134.1|148029_148485_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935151.1|159527_159785_-|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935145.1|155140_155506_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935152.1|159794_160067_-|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935149.1|157753_158923_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935147.1|155925_157143_+|hypothetical-protein	unknown	unknown	gnl|CDD|377414
NC_018607.1|WP_014935135.1|148497_149061_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935141.1|152585_153176_-|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935143.1|153979_154327_+|hypothetical-protein	unknown	unknown	gnl|CDD|183178
NC_018607.1|WP_014935142.1|153422_153944_+|DNA-damage-inducible-protein-D	unknown	unknown	gnl|CDD|183178
NC_018607.1|WP_014935153.1|160071_160560_-|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935136.1|149006_149261_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935146.1|155508_155850_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935140.1|151959_152574_-|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935148.1|157139_157751_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935137.1|149274_149862_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935138.1|149858_150179_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_018607.1|WP_014935147.1|155925_157143_+|hypothetical-protein	gnl|CDD|377414	pfam04865, Baseplate_J, Baseplate J-like protein. The P2 bacteriophage J protein lies at the edge of the baseplate. This family also includes a number of bacterial homologs, which are thought to have been horizontally transferred.	1.55637e-08
NC_018607.1|WP_014935143.1|153979_154327_+|hypothetical-protein	gnl|CDD|183178	PRK11525, dinD, DNA-damage-inducible protein D; Provisional.	1.73641e-16
NC_018607.1|WP_014935154.1|160556_160766_-|hypothetical-protein	gnl|CDD|225288	COG2433, COG2433, Uncharacterized conserved protein [Function unknown].	1.76502e-05
NC_018607.1|WP_014935142.1|153422_153944_+|DNA-damage-inducible-protein-D	gnl|CDD|183178	PRK11525, dinD, DNA-damage-inducible protein D; Provisional.	2.27887e-39

Protein sequences

>NC_018607.1|WP_014935143.1|153979_154327_+|hypothetical-protein
MGSTELGANIFRITQTAEKIKSENIQGQYALEQAHKEVGKEVRESMKRMHNKLPEDLAIERDIKKVRSELKQTHKKMKKIPKSKKKKISKNYKPKRELPLRLFYSQKHNDKLTIV
>NC_018607.1|WP_014935142.1|153422_153944_+|DNA-damage-inducible-protein-D
MCDIITTDYEKIFENKSNSNGFLFWYARDLMITLGYKDYTTFKKSINKAIGICVSLNIEFPDNFVYIKRTIDGKEVDDYKLSRFACYLIAMNSDVKKPEVARAQAYLAKYAEIIITLSQQAEDIERIDLRDKLSEEEKNLSGIVYAHKVETYSLFQNAGYLGMYNMSLNKLKK
>NC_018607.1|WP_014935141.1|152585_153176_-|hypothetical-protein
MRKLIFLLLISIFSISCIYEDDTTGVIINWQKEGIPNAEITLIQRKDNKSFRDIKAITYIVPKNTNSIQSPTSIKECFIIKDAANVFDENYKQQIKIDKKYMNVVFKYEGKELYFKDWNNKEYKLKYQGFPVFKGTDKDFQRADFLNLGLEGLKGNSWVGVLYFINEFTKSGEYLQHKNEPETADFFNSYTNKFMK
>NC_018607.1|WP_014935140.1|151959_152574_-|hypothetical-protein
MKKLIFLFGIFYFSVFCYAYKVPKDVVKIKDDNKLHYELNRANYKIVILEEQEEDPITYRPHFFIIIRTQTPITKKDLEENKMCFFETTINNEAYAYSSTPYYISVNEKINNEMYYHQEMDISEEELKELSEKKVNAVFIRPENFSGAYELKEDLEYLKSINLSSIQIKETDGYFINGEIEKDASKFISDLSMMIDFYFEISYY
>NC_018607.1|WP_014935139.1|150819_151911_+|hypothetical-protein
MRAYRFVLLDKKEFDTTEPPKGFYSGKKIVLEQNMDRSKTFDNIHIEFDIQQLVDNEEKEVFDTATIFLYNVNRYWHNENAQKIINNAKIVLYAGTKASPIHYHQGLIDYKEGSCYAFTDADITLTPIYQGYVKNAYPDMDGVNTVLKLNLANESFNEEITGLVQFNIKNGEEWRPSVKKFLEEIIKKEGLSLTTEIGEPSKGSLERAKCNTNPININGIFRPSSKNGVSLAAYVKKAFNEIIYKDGNVIYIGQNKNIVNKPPVVIRDKNLIGQPQMTGLKTISFSVPMTSKFRVLQKIKLELESFVSINQMFYGEGDLGYNPLNRADKMFKGEYQIIQIWHKGQSRNPNAESWCTTIEAVEI
>NC_018607.1|WP_014935138.1|149858_150179_+|hypothetical-protein
MTLLQSFSFTINTEGSFAEQYPDLRRGAYTQKITINDSSYTFKIFPNFYMENVEVSILNEAEEAIISNIPFNITENINYLIGDISFNNYKLIYNMKKQQFELYSVA
>NC_018607.1|WP_014935137.1|149274_149862_+|hypothetical-protein
MLIQSLLGSVSSLNKNTAFSFQSITAKYNKFAVILPDTVSIMNGYVSPIDLPLPLVGFEVSYNGDIPFLVNEYSEYPYLNKQLLIEGAVRQNADFSVILHNIITSANPWTVQNIKNQIFVDALEYYVQQGGTFNILTPWGDIKYAVLVGLYGIENEAAQKGISFRLDLKTLIPVYKNETDKLVSKLSNYITGAII
>NC_018607.1|WP_014935136.1|149006_149261_+|hypothetical-protein
MEEYFYDTITNPRDFRGIGLHIYKNGNIERIPIENSIADFLFRFPFDYFQDYINMYFSNEVKKDLKEEGIKNYNSLIHYLKKSF
>NC_018607.1|WP_014935135.1|148497_149061_+|hypothetical-protein
MDNAKIDYNTANIVFPINTPNGEIKVFIPPVNKEEVKSNALVLGGFAMYIDSINPAVLLTDYDVYINEVIEKFANEKYKSNDPRYKKYINDSKLKISAMLERSIAAGYYFEDNEVKPLNSINGEAQDIIKASLLFFIVILRYIKPQLTLEEWEEKIKSLSLTFTSSTVTEWKNTFMTQSQTQEISEV
>NC_018607.1|WP_014935134.1|148029_148485_+|hypothetical-protein
MPQLPSYLERFINKAVTSLIFPDDPDLNLTAFDMGEDAASMSIDEETVKRLKVNFGDVGAVEMAVPVTINVSIIKVVTPAETWRKRIFTNGLVQGANRTCIFTDDVGNEYSIFACTLSMGEVSANASSPVYNFTVKGTLAVNTDLYGILIG
>NC_018607.1|WP_014935145.1|155140_155506_+|hypothetical-protein
MKNITVEDCTLTTDNATAKATIIDAPSTKVKAEGKGVYKTPLKVQVEGATQGSFTQTAPSTGTIISTAKKVKADNILVILEGDKTNTPVQCPASDPNTGATTTIPVTVTIQAAGQTKVKGA
>NC_018607.1|WP_014935146.1|155508_155850_+|hypothetical-protein
MSAWLLDIEGNWHEANGDIEIRTIDFITRLQTIKGEQSFNANNGLDFLNIINGSSLLEVEVENIARDFNNYFDINIGNAEEDRKAKVMKIDINMKLKNSSNNETLNYTALIGA
>NC_018607.1|WP_014935147.1|155925_157143_+|hypothetical-protein
MQIGNTGVIKDSPTVIRERLLNKAIEEAEGFTNLPSGIQNNLIDESVIIENEIQDMLSNVMNSISPSYANDFIVKELGEAFGLKMKDKALPNTTITFYGLAGVVIPEGLEIGNADGSKKFITTKSDIINASGQVSIYCEGADYYDTPTPANTLNVLLNQVLNVTSCTNLSDAVESTPAETISEFRARFQTRAQANRSGTVATLDNALKEVEGTVDRLCTYKESQILEDGVKKAVIEVVIGGGDDYKVALAIFNSVLYPDIFVSNPSGDETNRTVNINVTFNSVDFPITYTRPKINQLSINISLTVQSGFINIPSEAFTLLLRPYYENYINNLKIGYSPTEYSFDDLIYQCFKDNSYSRDIITGINYTLNINGAPASLNGERQLETAFDTAYTLLDLECTLTGASV
>NC_018607.1|WP_014935148.1|157139_157751_+|hypothetical-protein
MIEKLSDIHVWQQYKRSDAIVNYFAFFRDYIQENYNDLFFKYNKETKQIELGEYAKEFSINQAQTDYLEYYLRSIYNMLRPHYLVDRTFYDSGLKYDSLYKYDETGTAELVPVSLLKKIFTFVYNLKYTHWSIPNLAAMLANFCEINITEVRIEIDTTRLKYFKFYLPTNKNSQDFRIIYNTYRNILNMPIGFNMELNLIDEV
>NC_018607.1|WP_014935149.1|157753_158923_+|hypothetical-protein
MRELKNNIFNNNIAGDTSNILIPDSSAIKNGIAFKSNINSNVLNGFYNILSEAIQYLQFTVGLYNKEADYNEGNIASLVIKDSENYSIWQFRRNSNNPQVLNNNPPITGASITTINGIDIYKGGTLNTDWDKLTQNYNVEAISNTVMIRDEVGASNVNTPSNIKNTTIVNNEYLEKQLQAGLSTKQDKLKAGTNVEITEDNVINVKGDVATDANLVTQTNEALGDNVQTALDILNSRYMIPPYYTQYPLENGNFDANEEPSNWYKKMYNITTTWQIMFNTESVYFRTEGDLANAGRSNGLQNDAGRNAGGSFYTLFANGNIKGVFYEGYITPRGFMPLDSTIWSEGVITMDLSHAYATANEFRVKNRLMRIYKLLTINDKSVNEIMEEF
>NC_018607.1|WP_014935150.1|158924_159521_+|hypothetical-protein
MVFVIYDKYNYKCYFVEGQSINDFKLKPNEVIKAHNSKDLSQTDIRAYNKDGSVKSLEEQVQEKIITLKDNEIIDNGIIRELNKNYEDDYIVMIERGLEKLDDNKKIVEDNGKKYVREKSIEEKYNEGLITKEEYNAYIVNQRQNQYSQNLDGARAELLDSVLNTLANQGLLNETQMEALKNIQTTRANIKEQYPKQS
>NC_018607.1|WP_014935151.1|159527_159785_-|hypothetical-protein
MIWYEKLKSFDFNHVKNIAKKYGKNKIIAEKLGLTNRQFRLLKHENKTIIHKEYRELAVKFAIAVEEGILEYKKNNLKKNLIQPY
>NC_018607.1|WP_014935152.1|159794_160067_-|hypothetical-protein
MKKNDIKIIENIFNQEASITENDSIIYVYLYFSHSGLFSLSFCKIKNDFGIYTTKTLNKEEAIKYQQYLDIFIKNYDVLYKIFLKYSNKR
>NC_018607.1|WP_014935153.1|160071_160560_-|hypothetical-protein
MNKEHTNLCYKTAEKFIKDVALIEYKCIYLSEEPDVIVFDSYGNTTLYEVKISIPDFWNDFKKPQRIQVKKKRELIYTLYPSLGKERYYVCPKKLIDIDELPEGWGLIWYDKDTDKFRLKKKSGVFKIDKGLECRLLVNALKRYKSGYTKSILLKDYLEYKE
>NC_018607.1|WP_014935154.1|160556_160766_-|hypothetical-protein
MPKLILVIFCFVCLWCFFWIAVYYQDIKNIYKKQQEYERDIRELEYKNNELKNQIEYLKNPYIEFGALQ

Crispr_ID: NC_018607_2

• CRISPR_ID: NC_018607_2
• CRISPR_location: 456722-456930
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_018607_2

Consensus_repeat	Method
TTTTTTATTTTTTTAACTGCTTTTTTTACTTCTTTTTTAACAGT	PILER-CR

spacers of NC_018607_2

>2.1|456766|22|NC_018607|PILER-CR
ATTTTTTACAGCCTTAGCAACT
>2.2|456832|63|NC_018607|PILER-CR
GAAGCTTTTTTTACTGTAGAAGCTGCCTTTTTAGCATCTTTTTTAATCTCTTTCTTTACTTCT

CRISPR arrays and Neighbor proteins around NC_018607_2

CRISPR arrays

The CRISPR arrays of NC_018607_2

>merge|NC_018607|2|456722-456930|PILER-CR
TTTGTTTTTTTTGATACTGCTTTTTTTACTTCTTTTTTAACAGTATTTTTTACAGCCTTAGCAACTTTATTTATTTCTTTAGTTGCTTTTTTTACATCTTTTGAAGCTTTTTTTACTGTAGAAGCTGCCTTTTTAGCATCTTTTTTAATCTCTTTCTTTACTTCTTTTTTTACTGTTTTAACTGCTTTTTTCACTTCTTTTTTAACATT

>NC_018607|2|1|456722-456930|PILER-CR
TTTGTTTTTTTTGATACTGCTTTTTTTACTTCTTTTTTAACAGT	ATTTTTTACAGCCTTAGCAACT
TTATTTATTTCTTTAGTTGCTTTTTTTACATCTTTTGAAGCTTT	TTTTACTGTAGAAGCTGCCTTTTTAGCATCTTTTTTAATCTCTTTCTTTACTTCTTTTTTTAC
TGTTTTAACTGCTTTTTTCACTTCTTTTTTAACATT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_018607.1|WP_014935374.1|455456_456284_-|histidinol-phosphatase-HisJ	unknown	unknown	gnl|CDD|213994
NC_018607.1|WP_014935381.1|464561_465188_+|chloramphenicol-acetyltransferase-CAT	unknown	unknown	gnl|CDD|366012
NC_018607.1|WP_014933786.1|467684_468623_+|methionyl-tRNA-formyltransferase	unknown	unknown	gnl|CDD|234567
NC_018607.1|WP_014935379.1|462028_463657_+|AMP-binding-protein	unknown	unknown	gnl|CDD|341240
NC_018607.1|WP_013243832.1|469406_470207_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|372616
NC_018607.1|WP_013243833.1|468652_469300_+|PASTA-domain-containing-protein	unknown	unknown	gnl|CDD|275384
NC_018607.1|WP_148271102.1|460062_460824_+|HAD-IIIA-family-hydrolase	unknown	unknown	gnl|CDD|319806
NC_018607.1|WP_014935380.1|463668_464523_+|aldo/keto-reductase	unknown	unknown	gnl|CDD|381364
NC_018607.1|WP_014935364.1|443650_444331_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935365.1|444804_445860_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935368.1|449260_450292_+|UDP-N-acetyl-D-mannosamine-transferase	unknown	unknown	gnl|CDD|237177
NC_018607.1|WP_014935378.1|461347_462004_+|channel-protein,-hemolysin-III	unknown	unknown	gnl|CDD|224191
NC_018607.1|WP_014935362.1|441491_442163_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224059
NC_018607.1|WP_014935363.1|442440_443658_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|226957
NC_018607.1|WP_014935366.1|446114_446681_-|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935371.1|452109_455004_+|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl|CDD|214599
NC_018607.1|WP_014935384.1|466803_467556_-|DUF3108-domain-containing-protein	unknown	unknown	gnl|CDD|378635
NC_018607.1|WP_013243849.1|448260_449241_+|6-phosphofructokinase	unknown	unknown	gnl|CDD|235111
NC_018607.1|WP_014935367.1|446771_448133_-|magnesium-transporter	unknown	unknown	gnl|CDD|225148
NC_018607.1|WP_014935377.1|460839_461292_+|phosphatase	unknown	unknown	gnl|CDD|350348

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_018607.1|WP_014935374.1|455456_456284_-|histidinol-phosphatase-HisJ	gnl|CDD|213994	cd12110, PHP_HisPPase_Hisj_like, Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like. Bacillus subtilis YtvP HisJ has strong histidinol phosphate phosphatase (HisPPase) activity. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to produce histidinol. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.	3.02969e-73
NC_018607.1|WP_014935381.1|464561_465188_+|chloramphenicol-acetyltransferase-CAT	gnl|CDD|366012	pfam00302, CAT, Chloramphenicol acetyltransferase.	2.00937e-85
NC_018607.1|WP_014933786.1|467684_468623_+|methionyl-tRNA-formyltransferase	gnl|CDD|234567	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed.	4.59681e-94
NC_018607.1|WP_014935379.1|462028_463657_+|AMP-binding-protein	gnl|CDD|341240	cd05914, LC_FACL_like, Uncharacterized subfamily of fatty acid CoA ligase (FACL). The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.	4.65308e-148
NC_018607.1|WP_013243833.1|468652_469300_+|PASTA-domain-containing-protein	gnl|CDD|275384	sd00037, PASTA, PASTA domain. PASTA domain is found at the C-termini of several penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular domain consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.	3.67071e-20
NC_018607.1|WP_148271102.1|460062_460824_+|HAD-IIIA-family-hydrolase	gnl|CDD|319806	cd07503, HAD_HisB-N, histidinol phosphate phosphatase and related phosphatases. This family includes the N-terminal domain of the Escherichia coli bifunctional enzyme histidinol-phosphate phosphatase/imidazole-glycerol-phosphate dehydratase, HisB. The N-terminal histidinol-phosphate phosphatase domain catalyzes the dephosphorylation of histidinol phosphate, the eight step of L-histidine biosynthesis. This family also includes Escherichia coli GmhB phosphatase which is highly specific for D-glycero-D-manno-heptose-1,7-bisphosphate, it removes the C(7)phosphate and not the C(1)phosphate, and this is the third essential step of lipopolysaccharide heptose biosynthesis. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.13386e-41
NC_018607.1|WP_014935380.1|463668_464523_+|aldo/keto-reductase	gnl|CDD|381364	cd19138, AKR_YeaE, Escherichia coli YeaE and similar proteins. Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.	3.39852e-138
NC_018607.1|WP_014935362.1|441491_442163_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	9.1648e-82
NC_018607.1|WP_014935368.1|449260_450292_+|UDP-N-acetyl-D-mannosamine-transferase	gnl|CDD|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	2.09577e-08
NC_018607.1|WP_014935378.1|461347_462004_+|channel-protein,-hemolysin-III	gnl|CDD|224191	COG1272, COG1272, Predicted membrane protein, hemolysin III homolog [General function prediction only].	5.47425e-14
NC_018607.1|WP_013243832.1|469406_470207_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.26275e-31
NC_018607.1|WP_014935363.1|442440_443658_+|ABC-transporter-permease	gnl|CDD|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	7.03816e-25
NC_018607.1|WP_014935371.1|452109_455004_+|methyl-accepting-chemotaxis-protein	gnl|CDD|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.04317e-32
NC_018607.1|WP_014935384.1|466803_467556_-|DUF3108-domain-containing-protein	gnl|CDD|378635	pfam11306, DUF3108, Protein of unknown function (DUF3108). This is a bacterial family of putative lipoproteins. Structure 3fzx, the first structural template for this large family including several homologs in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Bacteroides fragilis glyA is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA|QNQDC, and a Phobius server prediction of non-cytoplasmic localization for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit Structure 2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.	1.66514e-12
NC_018607.1|WP_013243849.1|448260_449241_+|6-phosphofructokinase	gnl|CDD|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	8.54532e-174
NC_018607.1|WP_014935367.1|446771_448133_-|magnesium-transporter	gnl|CDD|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	4.36591e-133
NC_018607.1|WP_014935377.1|460839_461292_+|phosphatase	gnl|CDD|350348	cd14498, DSP, dual-specificity phosphatase domain. The dual-specificity phosphatase domain is found in typical and atypical dual-specificity phosphatases (DUSPs), which function as protein-serine/threonine phosphatases (EC 3.1.3.16) and protein-tyrosine-phosphatases (EC 3.1.3.48). Typical DUSPs, also called mitogen-activated protein kinase (MAPK) phosphatases (MKPs), deactivate MAPKs by dephosphorylating the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr motif residing in their activation sites. All MKPs contain an N-terminal Cdc25/rhodanese-like domain, which is responsible for MAPK-binding, and a C-terminal catalytic dual specificity phosphatase domain. Atypical DUSPs contain the catalytic dual specificity phosphatase domain but lack the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. Also included in this family are dual specificity phosphatase-like domains of catalytically inactive members such as serine/threonine/tyrosine-interacting protein (STYX) and serine/threonine/tyrosine interacting like 1 (STYXL1), as well as active phosphatases with substrates that are not phosphoproteins such as PTP localized to the mitochondrion 1 (PTPMT1), which is a lipid phosphatase, and laforin, which is a glycogen phosphatase.	9.72257e-11

Protein sequences

>NC_018607.1|WP_014935374.1|455456_456284_-|histidinol-phosphatase-HisJ
MKYISNLHTHTTYCDGKNSIEENILYAIEKNFISLGFSGHSYLPFDNSSMSIENTIKYLEDIKKLKEIYKDKIQIYSGIEADYYSNLNKITDKEMMLDYRIGSVHFIKDDENNYFSIDSSKQNFENTLKHFGSIKEVVLRYYNNLIDMINTQKTDIIGHLDLIRKYNFNKEYFTEKEDWYIKKLDEVLEVIKKSNSIVEINTRKMNKDNLNAHYPSNYTIKKLLKLNIPIIINTDAHSANTLDYFYYEMAEELKKLGYTKIKMLIDNSFKDMSIN
>NC_018607.1|WP_014935371.1|452109_455004_+|methyl-accepting-chemotaxis-protein
MSLKNKVLFSVILVVALSLSPTIFINSTTNRKALYDNAMTVTQNYFYDIVSTFNNIYSTTSVGTVSLSDIATVAYELYDVGNIENPQRSLRDIIYRFHKSQLNLHHVIANGIYFEPNVITENTNLRNLYSLYLYDVPDAGTMEPQFGTIMDNYINEEFYSLALPNNWNREDKRPQDVYYSSPYMKNLDKPQKVISFSSPIYSTDNSRLIGVSLSDVSLDIAHEVLTNIVKTGPFNTIIYDTRNNKIVYHDNPKYILSNVNDFPWFNAAINNLDISTNTIIKNKVMIDDVPYHIFVRQFSSGLYNLFMFVPSSYFSSVLDQTNNTIFVILIFAIIVIIIILSITIPISLKPLDRISHELEEGVFNNNMFINITKINSKDSLGYLSSWIIIFFDMVQHVFSTVSKTLSVFKAQITSLKNKTSDISNVAGSMTESVNLIVDNISYQQKEFKAFESSNLEIYKIIASNLSELVSIDQMTNDLQIKIDEQAISLNQINSLTLSIQKDMEEVSESVAKAKDESEVMLSLSNDSRDKILKTENITRNLVSSIRGISEFVNSTIDISQQTNMLAMNAAIEAAHAGEQGKGFAVVAEEIRKLATTTNVQSEKAHRILREIEKEMNLMIEKMAERMNIIENMISKVNNFVDTMTKVKKVVDDKYVSTKDMNIAIERLTNAIKDIKEQYTSLHGRISVAKDDLVNLSDFSKKNDEAMKLISKNSDDIVSKTQDMSARINDVFNLIKEIESLSNISGDSIETLDREMSAYVVKDFEEVMAGKISSINDGERAYAKYALIKRFYKFMIETFGKEKTIALIAKMPEDAKIIYSDVKKVKFKKKFVLSSSFFIPITIIMNEFYEGSTDCIRDVAKYGFRKCSVLNKVKIRFYKGRTLADLLIKFSNKRFKNIHIDVVKSEKRKIIYHLYYFPNYDSMMEIYFDELINNIFRYRYPNSAKVEISKSISNGYIYTEYIVTW
>NC_018607.1|WP_014935368.1|449260_450292_+|UDP-N-acetyl-D-mannosamine-transferase
MINKNSLLGIRIDTFNNDLYAALDQLKDGNDVLIVTLDVHQLLNVRFNKKLKNIIENASLVIAAHPSISKAYKFIYKEELEYIKDFSLFSDILSYIEQRKMTMFLFGDEEKYFFTITEKMKKIYPDISILGTYQNTKNKSELDKAFIGFKKMNPDVFFIYMPFKKSLYWFNENNGKLGMKLCVPMSRPLDCFCGKKKSPSLKIIEANKDESFYLKRNIFRIFLYCDYIKFWILVFFEKISVNRAKKRIIKNAKKEAKREVKLEKIKAKELKKEEKKALKESKKEAKMEAKGEKIRAKELKKEEKQALKEAKKALKEEKKALKKEKKALKKDKKLCKKKTKKNN
>NC_018607.1|WP_013243849.1|448260_449241_+|6-phosphofructokinase
MADIKKIGVLTSGGDASGMNPTIRSVVRTAIANGLEVVGIREGYQGLMYNNVYKMDAGSVGGIINHGGTILFSARSPEFQTEEGMKKAADNMKYNGIDALVVIGGDGTYKGALDFANHHEEFPVIGIPGTIDNDIFGTDYTIGYDTAVNVAMEAIDKLRDTATSHGRCFVVEVMGRHAGYIALEVGIASGAEDILIPETTTDIDKIVENLQIAKKRGKKSSIIVVAEGDESGGAMEVAKQIEGKTGFDTRVTILGHMQRGGSPTSRERLMAARFGYIAVKALLEGKRNVAVGIWKGEYTYTPLADAVKKVPKVDPIDLELCRTLAI
>NC_018607.1|WP_014935367.1|446771_448133_-|magnesium-transporter
MINSQYIEIINIIENKRWDKLKYLLNDMHPIEIVDIMRILESSKDKTILFRLLSTEKSALVFAELDANEQEELISSMNDKEIEELMHEMSPDDRTSLFEELPEEINKKIFSLMEKEDLDITKKLLAYPEYSVGRIMTTEYISISPNFSVNQTLEYIRKYGKDSETFEVIYIVDNKNTLLGYILLKDLLFANRTDIIENLMHTDIIYLSAYSDQEEAVLVGRKYDLLYIPVVDAKNALIGIVTIDDIFDIAEEEETEDFHKLGAISIDDDFTGNIKQAPILTLYKKRITWLFILVFINIFSGYFIGIFEETISKYVSLIFFLPLLIDSAGNAGAQSSTLIIRSLSLGDVKKSDWLFMFFKEIAISSILGITMSLAVSLLAIFRGGLMIALVVSLSMICVVVIGSLIGLCLPFIFVKLKKDPTTSSVPLVTSICDITGTSIYLLLASIILTKINI
>NC_018607.1|WP_014935366.1|446114_446681_-|hypothetical-protein
MKKYIVLIFIFAVCTIYANNYESMIKSMQLENMEELSISDENSTITFNQLAEYYASIVTDKNATPEQLEALGNIIKLWTDTINQNFSKEEIFTKYSTVTSTLSSMSILLILRIAIKDNNIPTEEMQKSIYESINNKFIPSFAQFKNDGWKTDFNFYVINMSAAVCKWYEDKSKKLDYPDFKVWRDGDF
>NC_018607.1|WP_014935365.1|444804_445860_+|hypothetical-protein
MKRYFIFFIFAVSSIAFADITPKFGIKNSFNYIDLKESEYIPNSILSNDTYFYLGFEYLNNNFYFSFKPAIRIYTKDNRELIYDNGNLIKQNDNKAYLSFTFDEIQFNYINEILGFYIGKRKFHFGEGFNRQYMFVGESVLYNDYEALYNTELNFYQGNITHSIGFITDTKAIDLLKEPQYYTSWYYLKYSSSHLGLMGITKYTYDLQKKNNLMLGFEASYIFDIGFKLYGNVTYNILSSDNIGKSLNDIKSLLGINYTFIYNYDFILSPYVEYFYEDSHSFYSIGLYLSFLNNLFNIITYFSHSPNYKMDLNTKLLINYNNFSFTFNYYTPLKNDEILEHIFEISLEYNY
>NC_018607.1|WP_014935364.1|443650_444331_+|hypothetical-protein
MFNKIIKILFIISILSFNLYSQNIFDDFVKIYNRNGKSYKMSGTFTDIKDGKKKVNNFDMIVGKDYKLMYLKNNNTLFLANNQGFFVQSRNQTSPLKISGSYVVTGAANMNDLMSINFTDDYKLDKVVSDEEVNLVKKNRSVPYAKATLKKIAGGYSIDFFDNSGKALKRGIYKIKDNYFNDMEFYNLIINTNTSTVCNISKTEPSSSSSSYFRSENMKMLFSLFK
>NC_018607.1|WP_014935363.1|442440_443658_+|ABC-transporter-permease
MNIIKLAFDNLWYNKTRTILNMILIIVSFISLMMISGYNNFTKEGIIISVNTSGGSVVIADKSYWDTKSEKINMLSINDFEIIYKKLDTIGEVNDYQKKLDISGLVGNESKSKFFSGYAYEKPSKIMSTVSIKEGTPIFDDDINTFVLGKDLGEFFNLNYNEEPYLNLMTDFGEGISLGSLMAVGAISLNNSASDAITIYSPLNAIYEIFGLEYGNAHNLLVYLKDYKKATEIKNNLNQYFNENNLNYEAKDWKDLNAFLLSVIEMNTNNYLIALFILSILVFVSVMQMLTTNFLERLNEFGTMRALGINIKNVTLLLFLEIIIMAVLSSLISIIISYGAASILNASNFIMKFPGATDGYPLSLLLTFKDTVLIFAWVLSVSILAGIYPIIKVIKMPIIEVIKYV
>NC_018607.1|WP_014935362.1|441491_442163_+|ABC-transporter-ATP-binding-protein
MIRCENISKIYKTKDYNIAANKNISLEIKDGEIVWVAGVSGAGKSTLLHILSSIDIPTEGSVYWNNDEVSKLSDKERSSFRLSNIGLILQSLELLKTQSVFDNVALPLKFLNESSSNINKKVNEILENLKIDNLKNKKPEQLSGGQKQRVAIARALVSEAPYIFGDEISANLDTETSKFIYEYIRETIKKRNGIGFFISHDELIEDYADKKYIMRDGGIILNI
>NC_018607.1|WP_148271102.1|460062_460824_+|HAD-IIIA-family-hydrolase
MVVGLTFDFNNNKLYTIDDNYKITKDNIQNPLSGYSISNLIVYDNKVFEYNESFNLVIDEAFNNGNLYGIPLYIPDANKKVNKALFLDRDGVLMEDVGYIGEVERVKIKKEFTDIVKYANEKNYITIVTTNQAGVSYNYYTNDDVKNVHNYLYEEYKKHDAIIDDFYYCPYHIKGNVEEYKLLSVLRKPEAAMHLSACKKYNIDLTSSFMIGDRDSDIVKIPFLKTLLIKTDVYDIVNVDNIVEVNDIYSFLI
>NC_018607.1|WP_014935377.1|460839_461292_+|phosphatase
MFELCHNLYVGNDHDCSVFEGAIVHACQSCFVRGVNGAVGNKTFYENNDDLYLNLLDISSLSYDYASPMIKKAIDFIDRKIKDKKVLVHCNFGMSRSPSICLLYMAKKGYINNSSFKEASKDFHKIYNYFSAGLGMHRYFERYWNDIMQF
>NC_018607.1|WP_014935378.1|461347_462004_+|channel-protein,-hemolysin-III
MSVLIKKNVSIICAIICIICASSAIAVLVVLIVNSKTGIEATSFSLYSSFLVIFYIINSIYHFFPFNNKAKKVFYILSHAFFIMMIWGVYIPPCLISLQDGWGWSFFGVITGLCVLGITLRSVFSYRWRGFTETIYYFLLNWVWLIAIQKISLAVGEYGAILYLTAFLLLNIAMVFYRLAMYEVNKRYTLFLPLFYSLLILSNVCHAIFMFRYVAHIV
>NC_018607.1|WP_014935379.1|462028_463657_+|AMP-binding-protein
MINEKLSEYIFNSIKENWDINAFCDYSKDNFLKYSDVAKHILKMHTIFKRMEIYKGDKIALCGSNSANWALTYLSIVSYGAVVVPILVDFAKDDIISILNDSGSKYLFMDKNIIEKIDKEKFSFLNRIFYLDNLTIFDHKNDLTEEYNEILDVQLENFSRETFSLTMFENDTLATIIYTSGTTGFSKGVMLNHNSLAANIRFAIDNMPIKPNDHILSFLPLAHVFGCLFDFLFPFSKGACIYMLSAIPSPNILLKAFDEVKPNLILMVPLILEKIYFKKLKPTIDKPIMKKLLTLPFISKILKNKIRDKLTESFGANFHEVIVGGSALNEEVERFLMDIGFKFTVGYGMTECGPLISYAPWDKHVARSCGCIIDTLEIKIDSNSPEEVGDIMVKGENVMLGYYKNPKATTDVLSRDGWLRTNDLGVLVDGKRIFIRGRSKNMLLGPSGQNIYPEDIESKLNTMPYILESLIVQRENKLCALVYLDAEQVANLNDEEIKTKLEEVRNNLNKLLPDFARVSSFEIQKEEFEKNPTKKIKRFLYK
>NC_018607.1|WP_014935380.1|463668_464523_+|aldo/keto-reductase
MSYILKSSNIMPKFGIGTWRMGENENKSSVEINSVYYALKNGVRLIDTAEMYGEGGAEIIVGEALKKANVDRKELFIVSKVYPHNAGRDNLFTSLKKSLSRLGLDYLDMYLLHWRGRVPLRETVECMEEAKKEGLIKDWGVSNFDIDDMKELESIKNGDKCSVNQVLYHLASRGVDFDLASYLLERNIVLMAYCPLAQAGNLGNDILNNSVIKNIAKKHNATSSQIALAFIMYFDKRVPIPKSSSEKHILENINSQNIILDKEDIELLNKEFPKPNRKMPLDIV
>NC_018607.1|WP_014935381.1|464561_465188_+|chloramphenicol-acetyltransferase-CAT
MFNIIDIENWERKEHYYHYSNVNQCTYSITLKVEVQNIVNSSFKFYPTIIYLISKTVNNIKEFKMSFEDSKLGYYDVVNPSYTIFNNNSKTFSSIYTEYNDDFNLFYNNCIEDIKTYSISTSFSPKACNIKNLFNISSIPWVSFEGFNLNINNCFDYLPPIFTIGKYFNYSNKILMPIAIQVNHRVCDGYHVGLFAESLQENIFNLKK
>NC_018607.1|WP_014935384.1|466803_467556_-|DUF3108-domain-containing-protein
MIKYVLTLTILISNIVFCYNQTFKEGEYIKYDVLAQVPEFNISGKVGTLEAKVLAISNVDGVPAYHLYAHVYSTGAANFVYKVSDVFEAWVSTNDFTPLLIVKDAQEGEWTNYETSRFNHKERYFIYNDKRTTDEKITYDGLAFDALSLVFFMRFVDKNIGTFSIDWLEAKNVKKDIRFIIEEGPEIKTKLERGKLKTVRIYEKGKYGTDALVAKDKYNQVPLDVIIAEQKLYGLTIRVRGIIREYKDGK
>NC_018607.1|WP_014933786.1|467684_468623_+|methionyl-tRNA-formyltransferase
MYNVIIAGSTDFTSDCILQLMKLDNVNISAVISTIDTKKDRKGNIIPNPVTVTALENNLNLLKPENINSDDFYNTLVDLNADFFIVVAYGKILSKRTLSIPKIMPMNIHGSLLPILRGASPVEHALLYGFSKTGTTLQKMDYKLDEGDVILQDEFDIDSNWQFNELYDNIKKSGVYILKEFFDDANKYISNLKKQDDSKATYCTKIKKEDGRLYFNKNALELHNMTKAFVRWPVAYCYYNDVSIKVFKSEYKESSNNSNDFGKIVHIDNEGIHVQALNGIYIIKELQREGKKRQSVKEFLCGNKLNINEYFN
>NC_018607.1|WP_013243833.1|468652_469300_+|PASTA-domain-containing-protein
MKELFKKIKSKFNNFYNAYIKKFMNKILPKGILTEDKSLLVIKRLIIFALFLFVLQGIIVSVVVFIVVKAGGESFVLPDVQGVEAFEAFNILAKEDMNLNIQSHYFKDYPLGTIVSQEPKGGMRVKRGRTVYLVVNVPEQALVKMPDLTGKSYDDAVSIISNEIISKIPSVTILPKLNDNNSAYDNNVVLSQVPNANEVIGINTEIILTVNNKTE
>NC_018607.1|WP_013243832.1|469406_470207_+|class-I-SAM-dependent-methyltransferase
MEKRKCEFCHSDEYKPYIKTDLVSYSKCSNCGLIFQDPIITQEEIDAIYDDNYFEYEVANHDNFFALIQLALKDIGFERIENELPNKNVLDIGCATGMTLNYLKSKGYDTTGIEICSASAEYARKHYNLNIYEKPLIDVGFPDNYFSFIHFSHVIEHVPNPADTLKEIYRILAKGGYLAITTPNADGMFAKKYGGNWRAVMPQHLWLFSKPVLSNYLQQVGFNIISDFSWGSIPIEKKPNKIVKKFFDKFVKKFNKGDVMLFLCKK

Crispr_ID: NC_018607_3

• CRISPR_ID: NC_018607_3
• CRISPR_location: 1042841-1042954
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_018607_3

Consensus_repeat	Method
TCACTAGCTTATTATATGCGAAGGCGAACATAGCAATAA	CRISPRCasFinder

spacers of NC_018607_3

>3.1|1042880|36|NC_018607|CRISPRCasFinder
ATAAAAAAGTGAGCCGAAGCTAGCTAGTGAGTTTAC

CRISPR arrays and Neighbor proteins around NC_018607_3

CRISPR arrays

The CRISPR arrays of NC_018607_3

>merge|NC_018607|3|1042841-1042954|CRISPRCasFinder
TCACTAGCTTATTATATGCGAAGGCGAACATAGCAATAAATAAAAAAGTGAGCCGAAGCTAGCTAGTGAGTTTACTCACTAGCTTATTATAGGCGAAGGCGAACATAGCAATAA

>NC_018607|3|2|1042841-1042954|CRISPRCasFinder
TCACTAGCTTATTATATGCGAAGGCGAACATAGCAATAA	ATAAAAAAGTGAGCCGAAGCTAGCTAGTGAGTTTAC
TCACTAGCTTATTATAGGCGAAGGCGAACATAGCAATAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_018607.1|WP_014935734.1|1031163_1032264_+|GTPase-HflX	unknown	unknown	gnl|CDD|274455
NC_018607.1|WP_014935738.1|1036755_1039413_-|NTP-transferase-domain-containing-protein	unknown	unknown	gnl|CDD|224128
NC_018607.1|WP_014935735.1|1032543_1034280_+|proline--tRNA-ligase	unknown	unknown	gnl|CDD|236405
NC_018607.1|WP_014935743.1|1044281_1045205_-|methylenetetrahydrofolate-reductase	unknown	unknown	gnl|CDD|238299
NC_018607.1|WP_014935737.1|1035813_1036692_-|DUF2225-domain-containing-protein	unknown	unknown	gnl|CDD|224569
NC_018607.1|WP_014935749.1|1048679_1050146_-|PTS-ascorbate-transporter-subunit-IIC	unknown	unknown	gnl|CDD|237262
NC_018607.1|WP_014935742.1|1043974_1044181_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935736.1|1034733_1035804_-|YjgP/YjgQ-family-permease	unknown	unknown	gnl|CDD|367632
NC_018607.1|WP_014935745.1|1046058_1046697_-|3-keto-L-gulonate-6-phosphate-decarboxylase-UlaD	unknown	unknown	gnl|CDD|237344
NC_018607.1|WP_014935741.1|1042965_1043772_+|5-methyltetrahydrofolate--homocysteine-methyltransferase	unknown	unknown	gnl|CDD|224328
NC_018607.1|WP_014935733.1|1030588_1031152_+|HD-domain-containing-protein	unknown	unknown	gnl|CDD|224627
NC_018607.1|WP_013243346.1|1034295_1034727_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|273701
NC_018607.1|WP_148271111.1|1047422_1048277_-|L-ribulose-5-phosphate-3-epimerase	unknown	unknown	gnl|CDD|237308
NC_018607.1|WP_014935739.1|1039437_1039974_-|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935752.1|1051272_1051704_-|PTS-transporter-subunit-EIIA	unknown	unknown	gnl|CDD|182114
NC_018607.1|WP_014935740.1|1040115_1042743_+|dihydropteroate-synthase	unknown	unknown	gnl|CDD|273959
NC_018607.1|WP_014933391.1|1029871_1030549_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014935746.1|1046723_1047419_-|L-ribulose-5-phosphate-4-epimerase	unknown	unknown	gnl|CDD|236181
NC_018607.1|WP_014935744.1|1045242_1046055_-|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl|CDD|319818
NC_018607.1|WP_014935748.1|1048349_1048658_-|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl|CDD|99905

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_018607.1|WP_014935734.1|1031163_1032264_+|GTPase-HflX	gnl|CDD|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	4.0016e-137
NC_018607.1|WP_148271111.1|1047422_1048277_-|L-ribulose-5-phosphate-3-epimerase	gnl|CDD|237308	PRK13210, PRK13210, L-ribulose-5-phosphate 3-epimerase.	2.4834e-173
NC_018607.1|WP_014935735.1|1032543_1034280_+|proline--tRNA-ligase	gnl|CDD|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NC_018607.1|WP_014935743.1|1044281_1045205_-|methylenetetrahydrofolate-reductase	gnl|CDD|238299	cd00537, MTHFR, Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase to convert homocysteine to methionine. The enzymatic mechanism is a ping-pong bi-bi mechanism, in which NAD(P)+ release precedes the binding of methylenetetrahydrofolate and the acceptor is free FAD. The family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from prokaryotes and methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The bacterial enzyme is a homotetramer and NADH is the preferred reductant while the eukaryotic enzyme is a homodimer and NADPH is the preferred reductant. In humans, there are several clinically significant mutations in MTHFR that result in hyperhomocysteinemia, which is a risk factor for the development of cardiovascular disease.	6.1799e-43
NC_018607.1|WP_014935737.1|1035813_1036692_-|DUF2225-domain-containing-protein	gnl|CDD|224569	COG1655, COG1655, Uncharacterized protein conserved in bacteria [Function unknown].	7.84696e-46
NC_018607.1|WP_014935749.1|1048679_1050146_-|PTS-ascorbate-transporter-subunit-IIC	gnl|CDD|237262	PRK12997, PRK12997, PTS sugar transporter subunit IIC.	7.23595e-155
NC_018607.1|WP_014935736.1|1034733_1035804_-|YjgP/YjgQ-family-permease	gnl|CDD|367632	pfam03739, YjgP_YjgQ, Predicted permease YjgP/YjgQ family. Members of this family are predicted integral membrane proteins of unknown function. They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this.	1.84776e-51
NC_018607.1|WP_014935745.1|1046058_1046697_-|3-keto-L-gulonate-6-phosphate-decarboxylase-UlaD	gnl|CDD|237344	PRK13306, ulaD, 3-dehydro-L-gulonate-6-phosphate decarboxylase.	1.00259e-127
NC_018607.1|WP_014935741.1|1042965_1043772_+|5-methyltetrahydrofolate--homocysteine-methyltransferase	gnl|CDD|224328	COG1410, MetH, Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism].	3.78387e-29
NC_018607.1|WP_014935733.1|1030588_1031152_+|HD-domain-containing-protein	gnl|CDD|224627	COG1713, COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism].	2.72408e-43
NC_018607.1|WP_013243346.1|1034295_1034727_+|GNAT-family-N-acetyltransferase	gnl|CDD|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	5.9083e-15
NC_018607.1|WP_014935752.1|1051272_1051704_-|PTS-transporter-subunit-EIIA	gnl|CDD|182114	PRK09854, cmtB, PTS mannitol transporter subunit IIA.	7.25373e-31
NC_018607.1|WP_014935740.1|1040115_1042743_+|dihydropteroate-synthase	gnl|CDD|273959	TIGR02082, Methionine_synthase, 5-methyltetrahydrofolate--homocysteine methyltransferase. This family represents 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13), one of at least three different enzymes able to convert homocysteine to methionine by transferring a methyl group on to the sulfur atom. It is also called the vitamin B12(or cobalamine)-dependent methionine synthase. Other methionine synthases include 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (MetE, EC 2.1.1.14, the cobalamin-independent methionine synthase) and betaine-homocysteine methyltransferase. [Amino acid biosynthesis, Aspartate family].	0
NC_018607.1|WP_014935738.1|1036755_1039413_-|NTP-transferase-domain-containing-protein	gnl|CDD|224128	COG1207, GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane].	2.973e-55
NC_018607.1|WP_014935746.1|1046723_1047419_-|L-ribulose-5-phosphate-4-epimerase	gnl|CDD|236181	PRK08193, araD, L-ribulose-5-phosphate 4-epimerase AraD.	7.24919e-171
NC_018607.1|WP_014935744.1|1045242_1046055_-|Cof-type-HAD-IIB-family-hydrolase	gnl|CDD|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.71838e-84
NC_018607.1|WP_014935748.1|1048349_1048658_-|PTS-sugar-transporter-subunit-IIB	gnl|CDD|99905	cd05563, PTS_IIB_ascorbate, PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a transmembrane channel IIC subunit. Subunits IIA, IIB, and IIC are encoded by the sgaA, sgaB, and sgaT genes of the E. coli sgaTBA operon. In some bacteria, the IIB (SgaB) domain is fused C-terminal to the IIA (SgaT) domain. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include ascorbate, chitobiose/lichenan, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	4.89561e-24

Protein sequences

>NC_018607.1|WP_014935740.1|1040115_1042743_+|dihydropteroate-synthase
MFNSVKDRLKESIREQYLIIDGATGTELQKKEIKKEYWTFNGNNIEGCNEILNITAPHIMKEIHIDYLNANANITKTNSFGAIPWVLSEYDIADKAYELAKQAAVIANEARDEYLKNPNSKGDLDRDIFIAGSLGPGVKLPSLGQIGFDEMYSGYTLAARGLIEGGVDIILLETAQDVLQLKAAILAVNDTAKKLNKDIPIMVSVTIEKEGTMLLGTDIETAYTILSNLDIFSIGMNCGTGPDMAMQHIKKLSEISCLPISIHSNAGLPENRDGKAYYSMTAEEFTDINSEFFNLSGLAFIGGCCGTTPKHIEALAKKVKGVKPKKTALEKQRAYIASLFNSVSIKQEPAPLMIGERSNATGSKIFRELMIAGDMDGMLDVGIKQVKSGSHAIDVNAAWAGRDEIEDITKIISAYVKQISLPLVIDAIKPDVIEAALKVYGGKPIINSANMEQGEEKFDAICSLAKRYGASIMLLTIDEKAMALTCEDKLRMCERMYDRAVNVHKILPHDIIFDPLTFTLASGDENSFLAGVETLNAMKELSKRYPESSISLGVSNISFGLKEEARKVMNSVFLYEAINHGLSAAIVNVAQILPISKIGDKEIELARELIYNKNKTKEPLIKYINYFSDKKEKKELTNVTNEEKIKKPIREAIRDAMLDGEWKDMQNLLNEVKENSEEFGGEKKFAQAIIDEILLPTMADIGVKFGEGSIQLPFVLGSAEVMKKSVDFLSEFLEKKKQEKTAKIILGTVAGDVHDVGKNLVEIIIKNNGFETVNLGTKVPIEKFIEAYHEHNADCIGMSGLLVKSTEVMKDNLAYIRDKGLKIPILLGGAALTKDFVENTCKKVYGDSGKIFYCKDGFDDIVAIKEIIADRDKEK
>NC_018607.1|WP_014935739.1|1039437_1039974_-|hypothetical-protein
MSIDDKTKSALIRKGNELFNERKIEEAYRCYLTASYFGGIEKIADYYNFEGKNFIKAMQLYKFILKEDSNLGGNIRAKQKLDTLSQSVAKVLQKWLNDDETFSNSKTTKLSLDSKNTYLLNNYKRNSLEDILNAKEKLDEEKLDKNKLNKDNNNKINNNDNKIIKKPVFEQIYKNKNK
>NC_018607.1|WP_014935738.1|1036755_1039413_-|NTP-transferase-domain-containing-protein
MTKREEANNIKNVEESLEQLSSKFSKNDSLVIILAAGHGKRIRSSTSKMLHTIWGVPSIERVRLAVKNGINKSNITIVVGIKALEVANAVGKQANTNFAYQEKQLGTGHAVKVGLEKSDLKNIKYCYVIYADMGLIDSNTMKEFHDEFMKAKTDMILMTAMYDGPKGGNYYGRVLRTRGLTKDHKKSQYREGSKGQVMGVIEYKDILALKDDEDLVKAYKDEKFEYGKDELLDNMHEYVAGIYGFKIDPLLNLIKELKANNAQNELYLTDLIEMFVNNNLSISTYMPKDNRVVLGFNDKTVLKEMESIARNNVYNKLKNIITIYDGEDFFIDDSVVEQILEIDKDEKPLDIYIGKGAYVGKGVKINYGVYIDHGARLEGNIELGEHTYIGDNALVSCLDNQKMVLSNNVQIYAGNQIRGNVYIGENTTLERGVNVTGSDKHPLSIGKNVLIKGVSYIYGSIVDDNAYIEHCIFYYSHIKAVLDENGKVIKCRFIRPKEEGIESVIKLKDEKIKKLKRNKIFLILIAISIFYSNINAQYERDINKDAPPLSKHYYRISSFESISTWSVASLNSEPYISELLIDPNNNLHIAYYDDKINAPVYVFGKNGNFKREILDKNRELGSLISIASNSDNMHISYLKNNKIWYANNNSGTFNNYAMDLRNNRKIIDLKLVVSTFNSPILFFIDSKGILSVSRFYRDNFFSDLVYTNKIIEKVYPVAENDGYAVYMKEYSTGNLFYASRKTNTAFTFFDNNQILNNVNQYTVEHEAHNRFNIIYNTKDNTKEIRYKKFYDGNFIDGIVATEDQNIISFDSTLDYASQPVVLYTKEDGNKYIYIDGQTIDLSILGKSAGEVRINAARYPEFYIAYYNTLFKELRISKLNISDIEK
>NC_018607.1|WP_014935737.1|1035813_1036692_-|DUF2225-domain-containing-protein
MAEELKISYFEKNPRTCPVCNKEFYHEMLLTGGGRLIAGNLRDDLRRTYEKSKKYGAVYPLIYVVAVCPHCLYAAFQEDFNMVDSHKIKEAFDSYEQRSKYMHEFFGPDIDFKKNRNLISGAASYFLALDGYRYHTKDSAPTLKKALSSLRLSWTLEDLASVYPNDNYDKLIPFFQYKASEFYTEAIEYMQNGKESFDKLKSFGPDIDNNFGYEGMLYMGALLGTDASKFIPDPNVKARTLVQAKRKISKIFGSGKSSKSKPSALLEKIKELHTRISEELTYLNENYGINVD
>NC_018607.1|WP_014935736.1|1034733_1035804_-|YjgP/YjgQ-family-permease
MKKLNSYLLKEFLSMFVGSLILFVILVTIADLSSKLSYYTEHPENMKYFITYHAARTPHNLYYLFPIALMFSSTYVLGTFVKNKEMLAVQNSGISLFKFSSPIFVIVIVLCLGLIGFWQFVAAPMNKISFEANDLGRGHKKAEYTGALNIFGANDYIYFIENFNFNENYLTNTVIVKLKKDGAIDMRISSPSVRWNDNERRWYVENGILAEFSDEKNISVKEITNYPLDVLERPEHFMNRPLLDSMSLTEEMHWIKLRKEVNLNTNNLETDFHYRISYCFSGFIIVLLASLFSKFSTQSVLVVSLVMVIMVALVYYSILMMFRSMGDGGNMNPFIAAWMPNIIFAGLCFLAFKKFY
>NC_018607.1|WP_013243346.1|1034295_1034727_+|GNAT-family-N-acetyltransferase
MIELINSIDDNIIESIFFISSKSEYITLSKNYIKEYIEDKNHKVVIIKDDENIVGFIIYFLLSPEIDILFIATYPHNKGYGNKLLSYLFDDAENNNVDSIKLDLHENNINAKEFYTKNGFQSIGVRKKYYNNKYSALILEKKL
>NC_018607.1|WP_014935735.1|1032543_1034280_+|proline--tRNA-ligase
MRLSKLFMPTLKEAPSDAIIASNKLMIRAALARKISNGLYSYLPLGVRVLNKISNIIREEMDAIGSNECIMPILVSKELLTPSGRWERFKKELFRLKDRNDVDMAMGPTHEEAFTITAQNEIQSYKDLPVTLYQIHTKFRDEIRPRFGVIRSKEFTMKDAYSFHITKECLDKTYNDMSGAYTKIFKRMGLDTVSVKADSGAMGGEGSEEFMVLSEVGEETIIFCSKCNYRANVEKANVMEDEEAKSYTDKALEEVYTPDIKTIEDLEKFFNTSSKNFIKSIIYKTEEDEVILVAIRGDLEINETKLSNALGGLDIELASEDIIKEVTGARVGFASPVGLKKKIRIFADKSIKTVADAIIGGNKDDTHIKNVNINRDFNVDVWGDFRVAKEGDRCPECGEKLYQKKGLELGHIFKLGDKYTQAFNFTVLDENNKAITPIMGCYGIGVNRALASVIEQNYDDKGIIFPISVAPYEAIVVAIDKETEESFKKAEEIYKALSAIGVETMFDDRKERLGVKLNDCDLIGVPMRIIVGKKSLERGVVEFKLRRDLESVEVKLEDIVEYVKAKKKELFDEINSKL
>NC_018607.1|WP_014935734.1|1031163_1032264_+|GTPase-HflX
MKRAYIIFVADSKEYRTKKINIDNILTELSMLCDTAGYEVADRFSFIQQKIVAGTYIGTGKLESLKESAIADNVEYFVFDNELSGSQVNSIEEGSNIKALTRTEIILEIFAMRAKTLTARMQVELAFLEFEYPRLKGKRSNLSQVRGVIGLRGGAGEKQLEYDRRRARERIHKLKTQLSKVEKSASTGRKGRGSTFRIAIVGYTNAGKSTLFNLLCKEDTYVEDKLFATLDTHTRKLYLSDDAPVEAIISDTVGFIDRLPHTLIASFKSTLSEVVEADLLLHLVDSTDEYIEEKLINVEATIKEIEASNIKRIMVFNKVDSLEENQKNKILTMYDDAIFISAKNNINIDLLREKILKIILESFNNG
>NC_018607.1|WP_014935733.1|1030588_1031152_+|HD-domain-containing-protein
MNNFDEKPILDYIKKYLPFREEHILSTRDLSIKLAKHYNVDVNKASIAALCHDLGKRYKEEEIRKILLEYDKKEYPKHITSALLHARVSAIITIEEFHIKDDDIISAIESHTVGHANMSMLEKIIYASDYLEPTRKLETADKLREEIFINFDEAFLKVVLESIYFVLSKKQYLSDKTIELYNSLVIK
>NC_018607.1|WP_014933391.1|1029871_1030549_+|hypothetical-protein
MKRLFFYIILLIYSTALFGFRDIEREDSFSSSKFNDWLLIATFNSDNVPSFKFVSKHDDKEWESLDSAKNEYYYKGDNSKAGIFAIYNMKYYQYRGYNPLYTKQLNSKYSNMLKRFYFYRFSGKGAGLIALDNSLVAVDTYSKYVYIYGMPIREKVTFGVDVPLEWGAADTNMSSGKDFMPFYMYDPVGHVNEDGSVVLYDQYKESFLDKEKRYKPVFNNKSIYR
>NC_018607.1|WP_014935741.1|1042965_1043772_+|5-methyltetrahydrofolate--homocysteine-methyltransferase
MPEINHKNHEHHINKPPFYGRKVFEFNKQIEKEAFDMINKIRLFRVGFGYSAKNQDMEKYNEMIKTKVEPKYEEMKKNIIENNLLEPVMIYGFYKTVTENDKLYIYDVETNKLKNEKIELPLERMENEPYNSIVDFFDKDEDTIGFTLVSLGEKYHKFLKSLYDNNDYKEYYFYNAIGIHIIENYVDILQSHMDNLLNLKNNGKRKHVGCRYSFGYKALSNMYGNKIIFDKLKPEEFNVILTESYMMEPELSTCAIVSFCEDAYYFAN
>NC_018607.1|WP_014935742.1|1043974_1044181_+|hypothetical-protein
MKLAKIFLMSIIIASSVFAQANTVYISDKGKKYHRGNCRTLRASKYSISIQEAKKRGYTACKVCNPPN
>NC_018607.1|WP_014935743.1|1044281_1045205_-|methylenetetrahydrofolate-reductase
MNNNVENFIKKLENNNEYCFTLEISPQAKYDLSYIEKKINNSNIQNYVDAFVVTDSPFANIKISPILAAIQLQQKLNNNKPFIATQTMRDKNSIALQNDLIGANYFDIRMILAVTGDAIANGNQKQAKGVFEGNSNLLIDIIKNLNKSKSLGEFTFKEPLKPIYPFCVINSYAKNDDSLKVRLAKKANSGVKAIFTQPIYEVERLEFLLKCIDELPLKEKPILVPGFFPVLTYKTAYFIYYKLSGSYIPEKWLSKLKKASDKSEEEERKTATELSTKLFEDMLKIHKKMHIMSLNNYEFVVDLLKNI
>NC_018607.1|WP_014935744.1|1045242_1046055_-|Cof-type-HAD-IIB-family-hydrolase
MNNIQLIATDLDGTLLNANHQISEYNKSIIKKASENGIKIILSTGRPTAAATKFLYDLDIDSELISFNGAMITDKTSNIIYQQNLDANIGKELINIAKKYNIFHQGFLADRWNMGFFDEKWVEFYVSIAKIDNYTIGFDNINDFSFSKFMFIGENNLLKEIAKEIDKTFGERIYYTFSRPVYLEVHSPNASKAKALEYLANKYNITSNNIMAFGDNNNDLEMLEFAGVSVAVENAEDNVKNKCKYITKSNLEDGVGYFINKYLNTQSNNN
>NC_018607.1|WP_014935745.1|1046058_1046697_-|3-keto-L-gulonate-6-phosphate-decarboxylase-UlaD
MAIPLLQIALDNTTLSGALKSAKAVGNEVDVIEAGTILCLAEGMEAVRCLRALYPDKIILADTKCADAGGTVAKTCADAGADWMTVICSATIPTMKAALKEVKELQVELYGDWTFEHAKAWKEAGITQAVYHQSRDALLAGQTWADSDLEKIKKLTEMGFKVSVTGGLEIDTLKLFKDINVFTFITGRSIRDAEDPAKEARKFKEEILKYWR
>NC_018607.1|WP_014935746.1|1046723_1047419_-|L-ribulose-5-phosphate-4-epimerase
MLEELKKIVFEENLELVKKQLVIYTWGNVSGLDRESKTFAIKPSGVDYDVMKAEDMVILDLEGKKIEGKYKPSSDTATHIELYKAFPEIGGIVHTHSSYATSWAQARKDIPAFGTTHADYFYGDIPCARPLTKDEIEGEYEKNTGLVIIETLKKRNINPMDIPGIIIASHGPFAWGKDAKEAVHNAVVMEELAKMAYRTIQINPQIKSVEQYLLNKHYFRKHGANAYYGQN
>NC_018607.1|WP_148271111.1|1047422_1048277_-|L-ribulose-5-phosphate-3-epimerase
MNNLFGIYEKALEKNISWHQRLLDAKELGFDFVEISIDETDERLARLDWTKEQREELVKSIFETGIKIPTMCFSGHRRFPMGSKNPETRKKAMELMEKAVIFASDVGIRIIQLAGYDVYYEKGDKETKQLFIEGLKKSLEMAAKYQVMLAIEIMDTPFLNSITKFLEYDKICNSPWLTVYPDLGNLTAWGNDVEDEIRKGIHKITAIHIKDTLAPKEGFEGKFKEVHFGEGCVDFVKCFKLLKELNYNGTFMIEMWSEKVDNPKEHVIKEKKWVLEKMREGGFC
>NC_018607.1|WP_014935748.1|1048349_1048658_-|PTS-sugar-transporter-subunit-IIB
MLKVLVACANGSGTSLMMKMTAEKALKSLGINDANVHHCALAEGKSTAINYDLVFCPLNFIDMFKEAVEKGAKVIGIKNVLSEPEFKQKLNESGYLEELKNK
>NC_018607.1|WP_014935749.1|1048679_1050146_-|PTS-ascorbate-transporter-subunit-IIC
MEILLKIWTYFAQNILTQPAYFIGFIVLIGYILLKKPWYECLAGFLKATVGYLILSVGSGGLVNNFRPILVGLKDKFNLQATVIDPYYGQNAVQAAMEHIGKSFSQVMLLLLIAFIFNIVLVAFRKITKIRSIFTTGNVQIQQAATAFWLIFFCFPELGDTPMLIVMSLLLGLYWAVGSNLTVEITQDLTEGGGFCVAHQQVFALKIFSTIAEKMKGKGEGKKLEDVKFPGFLSIFNENMVSTSILMLLFFGIILITLGRDYLVANNFMKEGQSFFFYTLTTALNFAVYLAILQLGVRTFVTELTQSFQGISTRLLPGAVPGIDCAATFGFGSSNAVTMGLLFGAAGQFLAIITLILLKSPVVIIAGFIPVFFDNATIAVFANNRGGIKAAMLLPFISGLCQVFGSAFIAYWVGLAAYGGYLGMWDWAILWPSFTIVMKYLGYAGIAIVAIVLIAIPQIQYMKNKDTYFLITDDYEAYKQKMKEKLNA
>NC_018607.1|WP_014935752.1|1051272_1051704_-|PTS-transporter-subunit-EIIA
MLKEFLKNNIKIVDSVENWEEALRIGAESLINNNNIEPRYVQAIIDNVYKYGPYIVLTDGVAMPHSRPEEGVLKKGMSFLKVKNGIEFYQTESKIYLFFTLAAENADGHQDAIAELAEFLGDDEKLEKIIKEDLTESEILDLL

Crispr_ID: NC_018607_4

• CRISPR_ID: NC_018607_4
• CRISPR_location: 1440047-1440194
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_018607_4

Consensus_repeat	Method
TTCAAGTTTTTTATATTTTTCTAATTTCTTTTTT	PILER-CR

spacers of NC_018607_4

>4.1|1440084|42|NC_018607|PILER-CR
AATTTTTCTATATCTGAATTAATTGTTTTCACATTATCTGTT
>4.2|1440163|35|NC_018607|PILER-CR
TCTTCTAACTGTTTTATTTTTTCTTTATATTTATC

CRISPR arrays and Neighbor proteins around NC_018607_4

CRISPR arrays

The CRISPR arrays of NC_018607_4

>merge|NC_018607|4|1440047-1440194|PILER-CR
TTCTAATTTCTTTTTTAATTTTTCTATATCTGAATTAATTGTTTTCACATTATCTGTTTTGTATTTTTTTATATTTTCTTCTAACTGTTTTATTTTTTCTTTATATTTATCTTCAAGTTTTTTATATTTATCTTCTAATTTCTTTTTT

>NC_018607|4|2|1440047-1440194|PILER-CR
TTCTAATTTCTTTTTTAATTTTTCTATATCTGAATTA	ATTGTTTTCACATTATCTGTTTTGTATTTTTTTATATTTTCT
TCTAACTGTTTTATTTTTTCTTTATATTTATCTTCAA	GTTTTTTATATTTATCTTCTAATTTCTTTTTTTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_018607.1|WP_014936009.1|1427092_1429105_+|DUF4954-family-protein	unknown	unknown	gnl|CDD|374484
NC_018607.1|WP_014936018.1|1441293_1441470_-|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_013243066.1|1443423_1443642_-|DUF3343-domain-containing-protein	unknown	unknown	gnl|CDD|378728
NC_018607.1|WP_013243072.1|1448325_1448892_-|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_014936012.1|1431451_1432240_-|pyrroline-5-carboxylate-reductase	unknown	unknown	gnl|CDD|223422
NC_018607.1|WP_014936022.1|1445817_1446591_-|CAP-domain-containing-protein	unknown	unknown	gnl|CDD|349398
NC_018607.1|WP_014936007.1|1423492_1425580_-|glutamine-synthetase	unknown	unknown	gnl|CDD|226477
NC_018607.1|WP_014933261.1|1434680_1435442_-|glucosamine-6-phosphate-isomerase	unknown	unknown	gnl|CDD|129593
NC_018607.1|WP_014933268.1|1445382_1445793_-|biopolymer-transporter-ExbD	unknown	unknown	gnl|CDD|223917
NC_018607.1|WP_014933267.1|1444775_1445348_-|sulfurtransferase-like-selenium-metabolism-protein-YedF	unknown	unknown	gnl|CDD|274630
NC_018607.1|WP_014936013.1|1432688_1434653_-|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl|CDD|224733
NC_018607.1|WP_115590354.1|1440527_1440584_+|hypothetical-protein	unknown	unknown	unknown
NC_018607.1|WP_013243074.1|1449232_1450312_+|aspartate-carbamoyltransferase	unknown	unknown	gnl|CDD|234849
NC_018607.1|WP_014936023.1|1446714_1448082_-|phosphoglucosamine-mutase	unknown	unknown	gnl|CDD|274906
NC_018607.1|WP_013243056.1|1430967_1431330_-|response-regulator	unknown	unknown	gnl|CDD|381106
NC_018607.1|WP_014936011.1|1429969_1430968_-|DUF4921-family-protein	unknown	unknown	gnl|CDD|238341
NC_018607.1|WP_014933260.1|1432239_1432674_-|PaaI-family-thioesterase	unknown	unknown	gnl|CDD|239527
NC_018607.1|WP_014936014.1|1435475_1438214_-|DNA-directed-RNA-polymerase-sigma-70-factor	unknown	unknown	unknown
NC_018607.1|WP_014936019.1|1441948_1443139_+|potassium-transporter	unknown	unknown	gnl|CDD|223104
NC_018607.1|WP_014936010.1|1429110_1429965_+|methyltransferase	unknown	unknown	gnl|CDD|234786

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_018607.1|WP_014936009.1|1427092_1429105_+|DUF4954-family-protein	gnl|CDD|374484	pfam16314, DUF4954, Domain of unknown function (DUF4954). This family consists of uncharacterized proteins around 660 residues in length and is mainly found in various Bacteroides species. The function of this protein is unknown.	0
NC_018607.1|WP_014936011.1|1429969_1430968_-|DUF4921-family-protein	gnl|CDD|238341	cd00608, GalT, Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme contains two identical subunits. It also demonstrates that the active site is formed by amino acid residues from both subunits of the dimer.	1.61638e-80
NC_018607.1|WP_014936012.1|1431451_1432240_-|pyrroline-5-carboxylate-reductase	gnl|CDD|223422	COG0345, ProC, Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism].	1.87525e-77
NC_018607.1|WP_014936022.1|1445817_1446591_-|CAP-domain-containing-protein	gnl|CDD|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	1.79595e-19
NC_018607.1|WP_014936007.1|1423492_1425580_-|glutamine-synthetase	gnl|CDD|226477	COG3968, COG3968, Uncharacterized protein related to glutamine synthetase [General function prediction only].	0
NC_018607.1|WP_014933261.1|1434680_1435442_-|glucosamine-6-phosphate-isomerase	gnl|CDD|129593	TIGR00502, Glucosamine-6-phosphate_deaminase, glucosamine-6-phosphate isomerase. The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars].	1.73937e-36
NC_018607.1|WP_014933268.1|1445382_1445793_-|biopolymer-transporter-ExbD	gnl|CDD|223917	COG0848, ExbD, Biopolymer transport protein [Intracellular trafficking and secretion].	2.8989e-28
NC_018607.1|WP_014933267.1|1444775_1445348_-|sulfurtransferase-like-selenium-metabolism-protein-YedF	gnl|CDD|274630	TIGR03527, selenium_YedF, selenium metabolism protein YedF. Members of this protein family are about 200 amino acids in size, and include the uncharacterized YedF protein of Escherichia coli. This family shares an N-terminal domain, modeled by pfam01206, with the sulfurtransferase TusA (also called SirA). The C-terminal domain includes a typical redox-active disulfide motif, CGXC. This protein family found only among those genomes that also carry the selenium donor protein SelD, and its connection to selenium metabolism is indicated by the method of partial phylogenetic profiling vs. SelD. Its gene typically is found next to selD. Members of this family are found even when selenocysteine and selenouridine biosynthesis pathways are, except for SelD, completely absent, as in Enterococcus faecalis. Its role in selenium metabolism is unclear, but may include either detoxification or a role in labile selenoprotein biosynthesis.	1.38633e-45
NC_018607.1|WP_014936013.1|1432688_1434653_-|N-acetylglucosamine-6-phosphate-deacetylase	gnl|CDD|224733	COG1820, NagA, N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism].	7.67409e-141
NC_018607.1|WP_014936023.1|1446714_1448082_-|phosphoglucosamine-mutase	gnl|CDD|274906	TIGR03990, Arch_GlmM, phosphoglucosamine mutase. The MMP1680 protein from Methanococcus maripaludis has been characterized as the archaeal protein responsible for the second step of UDP-GlcNAc biosynthesis. This GlmM protein catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. The first-characterized bacterial GlmM protein is modeled by TIGR01455. These two families are members of the larger phosphoglucomutase/phosphomannomutase family (characterized by three domains: pfam02878, pfam02879 and pfam02880), but are not nearest neighbors to each other. This model also includes a number of sequences from non-archaea in the Bacteroides, Chlorobi, Chloroflexi, Planctomycetes and Spirochaetes lineages. Evidence supporting their inclusion in this equivalog as having the same activity comes from genomic context and phylogenetic profiling. A large number of these organisms are known to produce exo-polysaccharide and yet only appeared to contain the GlmS enzyme of the GlmSMU pathway for UDP-GlcNAc biosynthesis (GenProp0750). In some organisms including Leptospira, this archaeal GlmM is found adjacent to the GlmS as well as a putative GlmU non-orthologous homolog. Phylogenetic profiling of the GlmS-only pattern using PPP identifies members of this archaeal GlmM family as the highest-scoring result. [Central intermediary metabolism, Amino sugars].	1.40644e-179
NC_018607.1|WP_013243056.1|1430967_1431330_-|response-regulator	gnl|CDD|381106	cd17554, REC_TrrA-like, phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains. Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.60394e-58
NC_018607.1|WP_013243066.1|1443423_1443642_-|DUF3343-domain-containing-protein	gnl|CDD|378728	pfam11823, DUF3343, Protein of unknown function (DUF3343). This family of proteins are functionally uncharacterized. This protein is found in bacteria and archaea. Proteins in this family are typically between 78 to 102 amino acids in length.	4.28773e-05
NC_018607.1|WP_014933260.1|1432239_1432674_-|PaaI-family-thioesterase	gnl|CDD|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	4.56677e-38
NC_018607.1|WP_013243074.1|1449232_1450312_+|aspartate-carbamoyltransferase	gnl|CDD|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	7.47214e-136
NC_018607.1|WP_014936019.1|1441948_1443139_+|potassium-transporter	gnl|CDD|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	4.7578e-28
NC_018607.1|WP_014936010.1|1429110_1429965_+|methyltransferase	gnl|CDD|234786	PRK00517, prmA, 50S ribosomal protein L11 methyltransferase.	8.81182e-57

Protein sequences

>NC_018607.1|WP_014936014.1|1435475_1438214_-|DNA-directed-RNA-polymerase-sigma-70-factor
MFKYLFLIFTIIINIIACSSKNVTVGEINAVYNKKEDSYTISFPEYNKIYPEYIKLEVNKKIKNGIVLSYNIETDNIPTLLDICVEEDNIKKTYSIVNPNVNQTINIELYATNFTPYLSNDKIKDIEISLESVGSYDTKEKVKISLSEKIDGYKNIDTTRLVLPESGHIAKSNPPFFMVNKKLNLIRVYLAQDLSFNNAYQYTIRNNNFFDITNKLNSGKWYIALDENGDTNLRKIYHFFITDKTKDINIITNTKANTQRPFIFADSQTLNLLNNIYNSKRIQQSAFLRNFNYFKLYTSNNMGKWYLDNISYTNENNDNKIYFENIPSHIMLMSLRSYLEEDNTILQYDIKQMIKNITLLNENSIENFNNVDAAYILANSLLMPFDILYDKLSSEEVVLIKQKFIDYGNILYKYIINNPSLYRDANNIKYITTLGLISLNMLNENLYQEEVRNWYLFSLKYINSMIFSMFEDDGSLKASLDNSFDIIFNILIYANALKNAEVDNVFEYESFKNIGKYLSIIGYPSGYTLPIGYTLIDNRSKMRFDSGARSAIMELLSKTYNNALYKNYSVFGQSEAIDIKYLPYMLLWNNHSIKDDALSVLNNEYQSSYFKNIETAIYNRDIKSLNSQYLGIYAKGYNAYKSYGLNHNDRMSFLYYNYGDSIIDELGYFYDNDANKEIFAYADFHNTIIISDTTNEYRIEEKPSSFSEIISFTNNNKLFFAKAKANNIYTYQTTLRNFERTFYYLKPNILIIKEDIEALPNINNENYINGYKYKWNINSKLPISNSNDGFIIDGKYSTSYIKLLSEDKLNYEVSQTNIGNQKLYTAKASTADKTKRFSPWIMVITMPKNNVAINERRNIINTNISINSFSYTNLSFKAGYKDYNINYKYLSTNNNEKIVYTENRENVIISSH
>NC_018607.1|WP_014933261.1|1434680_1435442_-|glucosamine-6-phosphate-isomerase
MNIYIADSYKDYTSFTANHILRFLEKKQKTKEKLYISVSSENDTKDIYKAIIENIKNYNINFKNIFIFQQSEYVGLSQDDKNSKAYFLKENLLSKLNIPKKNQFLFDGSKDESQMEKQLEIIKKIGRFDVIWYSLTPDSTSAGNERMSSLSSLFRLKTLSEHSIKAIESKFKKEVPTMVFSMGMGIIDIVDTILLTSSGIENSCSLRDCLECGISNSSPLSKLQKHSDVTVIADYESSLRLSSQTVSMKIKQN
>NC_018607.1|WP_014936013.1|1432688_1434653_-|N-acetylglucosamine-6-phosphate-deacetylase
MRIIITNESVYEWAAYYTVKCILDYSDRKKTFVLSFPLRYVDKSYYEKLLSFYNDNIVSFKNIHIVSSGEYIDSDISQKYLEENFIKHIDIPKENVHLFNSRATDRKKEARRMSNIIKKLGNITLLIDNLAEDGSFLLNTPSSSLEGSVRDKKISEIIRSYEAKKFNMPVEMFPREGLTLGFEEAFNAKYILVMANGYDVSDALSHCVEGAISQFYPTSVLQEHKKLIIVADEESSSDLKVKTYKYAKSLESKNLHPKELIKGLYKSYYALTNIRIFDGEKFIDGHCIVIENNIIKSVEKEIDVDAVITRIDLGGKIVAPGYIDLQVNGIGGYDINASPTVDTLKNMNEVCQRYGCTSYLPTVITNGDEYMLKIIDLFNSIEDLSVIGVLGIHFEGPYISHEKRGIHNEKFIREADMNMIKKINASKCVMVTVAPEMVDGKVIEAFAKAGKVVSVGHTNGTYNEIKEKIPYGITFATHLFNAMRPWGSREPGAVGAVLETKDMYTGLICDGVHCDFASVELAYKLKTGHICIVTDAIAPAAAPEIKEYIWAGKKIHRDGNRLIDDNGTLGGASITMSQSVRNVVNQVGATVEEALKMASLYPAKVMGIDDKYGRIKEGYIADLVVLDEKLVVKGVVFKGNYKEYNYDYEWESNA
>NC_018607.1|WP_014933260.1|1432239_1432674_-|PaaI-family-thioesterase
MQENVYKRLSDIFCKQDFLNFIDCKLEEADVGRVVISLENKKEFSQALGFMHGGMVATMLDTASGFAAFSVLEEGNHVVTSDLKINYLRPVVCKKVRCIGEVLKAGKSLIVVEASVLDEENKILAKMLGTMVVVPNSYNNKGDR
>NC_018607.1|WP_014936012.1|1431451_1432240_-|pyrroline-5-carboxylate-reductase
MIGFIGAGAMGLALIEGFIKAGINKNTIIASVKTKEKKEQIEKNIEIKTFNDNKKIAQEADILFIAVKPYMVKDIAKEIEKNIKKDATIVSVAASVSVAELKQLFNTENIIRIMLNTPVKTCNGFISVVESQNKVVEEAIVELLSKVAMVKIIPEDKIHAYNAMAGCSPAFMYILIEAMSDAGVLMGIDRKSAIEIASQVFKGAGSMVLESKKHPAELKDNVCTPAGITIKGVEVLEQKSVRSGMIEALIATYQKSIDSEKK
>NC_018607.1|WP_013243056.1|1430967_1431330_-|response-regulator
MPKKTILVLDDEKSIRTLFEEEFKDEGYNVVSTDSGEEALEMINKDNPHIDLITLDIKMPKMDGLDFLGKVRENHRELPIIICTAYNNYRHEFQVWNADGYILKSGNLTEIKDKIKRLIG
>NC_018607.1|WP_014936011.1|1429969_1430968_-|DUF4921-family-protein
MPHIRKDPVTKQSVIIASERMGRPSDYINIEEKHAILSSDNTCPFCKGNEDKTPEHSTIIFDDNKNWIVRIVPNKYPIIAQSNADELPEKNSLFEADICKGVHDVIIENPNHSFNYYNAKERDLFFIFEAIIMRFQELSKEKDMMYSLLFKNFGREAGASLVHSHAQMMTTPFVPIQIMEEIYGSLEYYNENKKCVYCSMIEEEKKINERVICENNDFIAISPFASKSPYQIYILPKKHSDSIVYSEDCISQFASIVKDIFNRINKVLGEISFNYVLHTLTPALEKKYSHSSHWFLDIMPKMSKLAGYELGSGVFINSITPEDATNDLKNAL
>NC_018607.1|WP_014936010.1|1429110_1429965_+|methyltransferase
MRIYSLSINITIGFEDIIEATIESGELDILGYNIEFPINNNNIAIVNIYNENQEKLENNLNIIKQNIDDMAEYDYEIKELNSDEYLTSYMAFLKPFKVGEITIIPNLKDDNNNEDGLYIAKQYAFGTGTHETTFLALEMINEYSKNNNISSKTIADIGCGSGILSLFCYKLGARNITSVDIDNDAVNCTLDNAKYNNIKLNNIFLGSADSLSNFQYDLVIANIETDILIAILPNLKKILKENGHLILSGILAEKENFMNEAIKQNNLTILNRKQKNDWISLLLR
>NC_018607.1|WP_014936009.1|1427092_1429105_+|DUF4954-family-protein
MKLCFLNKGVAMSYFFVKEDKEFRKLKENEIDFLKSQGCISQSWDKILIKNVDLTRIKDVTFHGKIKINELNGNVKYYNKLKVPASINRATLIDVFINGNVYINNIGRFIANYKIQNGVIIENAGAIYMEGESSFGNGVETSPIMEGDGRSVKIFYRLNSHIAYIVAMYRHKKLMRDNINKIIDDYAKSKTKKFGKIKKHAQIINARIIKNSLIDPYATIENTDEINNTTIISTKECPSYIGTSVILKDSIVLKGAHIVDGTVIKKAFIGEGVKLGRQFSCEDSLLFANCEGEHGEMFSIFAGPYTVTHHKATLLIASHFSFFNAGSATNQSNHMYKLGPYHHGFMERGCKTGSNSYILWPSHIGAFSTVIGSHYDNVDTSDFPFSYITEHGYHQTRLIPALNLFGVGLSRDENKWRDRDRRVGDKKDLIIFDVFSPYTVSKMIKAEEILNNIKKEIINDEVEYIKYKNMIIKTSSLNKYSNRYSIAIDLYLHNKLLEYIKESDNLNNIFNDTNKFYETWVDVGGLICAKEKLDDVILNIENNNINNVQDLVKSFEELYNNYSTDEKSWVINMIKKRYNINTINIDVIIKMLKEHLSLLTTSYEIFYRDVKKEYDLAKMVSCGIDDKTMMEEDFKAIRGTAKDNAFVIKYKNDVETKIEDINKLIKKLGN
>NC_018607.1|WP_014936007.1|1423492_1425580_-|glutamine-synthetase
MDKLPDIFESYVFNDNVMQEKLPKDIYKKLIKTIKNGERLDLELANVVAHAMKEWAIEKGATHFTHWFQPMTGVTAEKHTCFITQTKDGKVRMEFTGKELVQGEPDASSFPSGGLRSTFEARGYTAWDPTSYAFIKDNTLCIPSAFCSYSGESLDKKTPLLRSMEVIERESKRILKLFGHNNINRVYTTVGAEQEYFLIDRDLYLQRPDLRYCKRTLFGACPPKGQELEDHYFGAIKPRVLEFMKELDNELWKLGIIAKTEHNEVAPGQYELAPEFTITNMATDQNQITMELMKVIAEKHNLACILHEKPFSGVNGSGKHNNWSIATDTGLNLFEPGNTPSENKQFLLFVVAVMKAVDEYQDLLRATTASASNDHRLGASEAPPAIISIFLGDELTEIIESMENSKKYKKREAVEMEMGVNSLARFTKDSTDRNRTSPLAFTGNKFEFRMVGSSLSVSGPNIVLNTIVAEALSQFADVLEKSSDFDKDLEVLLKENIKKHKRIIYNGNNYSDEWVKEANKRGLCNLKTTPEALETFISQKNIDLFLKHKVLTKAEVLSRYEISLEEYNKVINIEALTLIDMINKYIIPFSLDYTEELVYIYEKKKSLKIKYDIEKDLLDRLTSLTNNLYKKLRTLEDYLSEAKKIKNISKSSIFFRDKVLACIEDMRPIIDELEKTVSKKYWKLPTYGDMLYSLA
>NC_018607.1|WP_115590354.1|1440527_1440584_+|hypothetical-protein
MIINIINYLLGLPKEMPT
>NC_018607.1|WP_014936018.1|1441293_1441470_-|hypothetical-protein
MIFLVLFNFYTCRKQSVVNPINRKNHNDGGNNNIYIEVGANTMINNEALSSFRLILKP
>NC_018607.1|WP_014936019.1|1441948_1443139_+|potassium-transporter
MLLSLALIFLCGMILGKIFSLLKLPSLLGLIITGIVLGPYCLNLLDNSILSISADLRELALIIILTRAGLNLDIEDLKKVGRPAILMCFVPASFEIIGMILIAPKLFDISLLDAALMGSVVAAVSPAVLVPKMLKLIDEKYGTNKSIPQLLMAGASVDDIFVIVLFTSFTSLVKGGNISYLDFVKIPTSIIFGLLLGIIIGFILSKFFTKFHIRDSAKVVIILSISFILVSIETSISNLFGGVIGISGLLAVMSIGAYLKKSKEELSKRLSLKYSKLWVAAEIILFVLVGAAVNINYAFNAGVLGIVLIFAVLIFRMLGILVSLIKTKLNKKERIFSMIAYCPKATVQAAIGSIPLSFGLASGEIILVIAVLAILITAPLGAFAIEVSYKKLLEHE
>NC_018607.1|WP_013243066.1|1443423_1443642_-|DUF3343-domain-containing-protein
MTKSFCYLKTPRDLIKAEKILSDAGIEVIVRPAPEPIFGVCNMAIDIKDNDKVYIVSLLEAAGLVVLIKDSE
>NC_018607.1|WP_014933267.1|1444775_1445348_-|sulfurtransferase-like-selenium-metabolism-protein-YedF
MKTVDARGVPCPKPLILTKTALMNASLNEEIEVLIDDEVAFHNITDFLNNNKITYSNNGMNFKITKNKELSQNDSAKEKSSGPVIAVVDKKAMGQGNDELGELLLKAFLGALKDANPKPEALYCYNGGVYLGIDEPYKSLLQELRDAGIKIFFCGTCVKFYELEGIKVEEQTNMLGIIEAMANASAVIRA
>NC_018607.1|WP_014933268.1|1445382_1445793_-|biopolymer-transporter-ExbD
MKFRHRFTIKKGIDLTPMMDIVFNLLIFFMIGATIMQTPQIEISLPKSTSAVGKEKNETIIITISKEGSIYVNEEAVNDIDGYLNNLAKVEGELAKPVEIRSDEDVRTQVLISVIDSVKNAGFTKLGIATDTKNNN
>NC_018607.1|WP_014936022.1|1445817_1446591_-|CAP-domain-containing-protein
MKKISLVMIFILISAFALHADVIEDEVFRLINLERSKVSLPPLPNNQRLHSLALYHSDNMAKNKFFSNTDLEGLDSKGRQLKLYPEMVGNITESFTKLDVIPLTDKNAAASIVKNLMNTPDYKKVILSKDFNAMGVGASKRGVGVYTTVTLANIIAESVNFKSEVKYGDDITVQYRILNKAPFTDFKIAVEMADPKAQIVGDDGKTYIGKVIYDVTDAGNTVISKTFKAEYGKGEYKVSLLYKGEHFSSNTRVITVK
>NC_018607.1|WP_014936023.1|1446714_1448082_-|phosphoglucosamine-mutase
MPTLKTSISGIRGIIGDGLDISTIVDYTSAFASLFPKKAKILVARDTRITGESILNAVVATLMASGINVIDIGITPTPTALYMVEKLKIHGGIMISASHNPIEWNALKLIGKGGHFLDEKAVNELMKLYDKKAKRFVKALETGTYQKIDNAIEEHIKRILRFINVEKIKKANFKVACDYVNGTGLFATPPLLKALGVKEVSINKEHTGKFAHVAEPSATSMKSLSELVKKNKVNIGFTQDPDADRLALVLDDGTIISEEYTLALCAKYLWLSGKGNAAVNLSTSRMIDDLAKEKGYSVDRTKIGEINVSSHIVKNKLYFGGEGNGGIIVPAVTPGRDSLLGIALILELMAATGKTIKELVNEIPKYEIVKEKLEVSKIDENNFLKQIKEKYNKAKITTIDGIKIDLEDSWLHVRSSNTEPIVRIIAEAKTKKEAKELISIAINMIKDNNKPKKTK
>NC_018607.1|WP_013243072.1|1448325_1448892_-|hypothetical-protein
MFKKIIIYSIFTVLIYSTSSAKLFSYFPTDSALGFSLRFSFPLQASLGVTGKFEGIPFMFGGILNIGISSKGASWFGFSASADWWGYTTRLGQLGDSDVMLYLGPGVEAIFNFAAKYVNIEADFRIPVGVSFIVKEDWEIFLQLTPALNVISVGTRGFATFGWYPESSGWAFGDFFRFYGDFGFRYWF
>NC_018607.1|WP_013243074.1|1449232_1450312_+|aspartate-carbamoyltransferase
MKNFIGIKEMSKEEILEVLDVAKRLDNTPNMERRKMMDGMIMTSLFFEPSTRTRLSFNSAAYKMGLDVIGFDNPDVSSIKKGESLRDTIIMVSAYSDVIVMRHPIDGAAKFAEEVTDCPVINAGDGSNEHPSQTLLDLYTLKDELGSIENKKIAFVGDTKYGRTVHSLSKALKMFNGEFYYISPDIIQIPDYILKELDNAGIKYHKGNNYEEILKEIDCLYMTRIQRERFENIEDYEKVKHAFNISKSTIVGKCKEDMIIMHPLPRVDEISIDLDDTKYAKYFIQAKNGVPTRMAMLSLATGIIESTAKKKEKDYELIENKEIVCQNKKCVTHFEETKNKVARRSYGDFCYYCNKEITK

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_018607_2	2.1|456766|22|NC_018607|PILER-CR	456766-456787	22	KT325596	Uncultured bacterium plasmid pFK2-7, complete sequence	34274-34295	1	0.955
NC_018607_2	2.1|456766|22|NC_018607|PILER-CR	456766-456787	22	NZ_CP010903	Acinetobacter nosocomialis strain 6411 plasmid p6411-66.409kb, complete sequence	47162-47183	1	0.955
NC_018607_2	2.1|456766|22|NC_018607|PILER-CR	456766-456787	22	NC_019217	Uncultured bacterium HHV216 plasmid pHHV216, complete sequence	24303-24324	1	0.955
NC_018607_2	2.1|456766|22|NC_018607|PILER-CR	456766-456787	22	NC_019299	Uncultured bacterium HH1107 plasmid pHH1107, complete sequence	24303-24324	1	0.955
NC_018607_2	2.1|456766|22|NC_018607|PILER-CR	456766-456787	22	NZ_CP044465	Acinetobacter schindleri strain HZE23-1 plasmid pHZE23-1-2, complete sequence	28481-28502	1	0.955
NC_018607_4	4.2|1440163|35|NC_018607|PILER-CR	1440163-1440197	35	NZ_CP006909	Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence	4074-4108	6	0.829
NC_018607_4	4.2|1440163|35|NC_018607|PILER-CR	1440163-1440197	35	NZ_CP044536	Borrelia sp. CA690 plasmid lp54, complete sequence	12805-12839	8	0.771
NC_018607_4	4.2|1440163|35|NC_018607|PILER-CR	1440163-1440197	35	NZ_CP009059	Borreliella afzelii K78 plasmid lp54, complete sequence	15294-15328	8	0.771
NC_018607_4	4.2|1440163|35|NC_018607|PILER-CR	1440163-1440197	35	NZ_CP018745	Borreliella garinii strain CIP 103362 isolate 20047 plasmid p_lp54_linear	14765-14799	8	0.771
NC_018607_4	4.2|1440163|35|NC_018607|PILER-CR	1440163-1440197	35	NZ_CP028862	Borreliella garinii strain 20047 plasmid lp54, complete sequence	42689-42723	8	0.771
NC_018607_4	4.2|1440163|35|NC_018607|PILER-CR	1440163-1440197	35	NZ_CP009214	Borreliella afzelii Tom3107 plasmid lp54, complete sequence	42970-43004	8	0.771
NC_018607_4	4.2|1440163|35|NC_018607|PILER-CR	1440163-1440197	35	NC_017241	Borreliella afzelii PKo plasmid lp54, complete sequence	15158-15192	8	0.771
NC_018607_4	4.2|1440163|35|NC_018607|PILER-CR	1440163-1440197	35	MN692985	Marine virus AFVG_117M57, complete genome	45015-45049	9	0.743

1. spacer 2.1|456766|22|NC_018607|PILER-CR matches to KT325596 (Uncultured bacterium plasmid pFK2-7, complete sequence) position: , mismatch: 1, identity: 0.955

attttttacagccttagcaact	CRISPR spacer
attttttacagccttatcaact	Protospacer
**************** *****

2. spacer 2.1|456766|22|NC_018607|PILER-CR matches to NZ_CP010903 (Acinetobacter nosocomialis strain 6411 plasmid p6411-66.409kb, complete sequence) position: , mismatch: 1, identity: 0.955

attttttacagccttagcaact	CRISPR spacer
attttttacagccttatcaact	Protospacer
**************** *****

3. spacer 2.1|456766|22|NC_018607|PILER-CR matches to NC_019217 (Uncultured bacterium HHV216 plasmid pHHV216, complete sequence) position: , mismatch: 1, identity: 0.955

attttttacagccttagcaact	CRISPR spacer
attttttacagccttatcaact	Protospacer
**************** *****

4. spacer 2.1|456766|22|NC_018607|PILER-CR matches to NC_019299 (Uncultured bacterium HH1107 plasmid pHH1107, complete sequence) position: , mismatch: 1, identity: 0.955

attttttacagccttagcaact	CRISPR spacer
attttttacagccttatcaact	Protospacer
**************** *****

5. spacer 2.1|456766|22|NC_018607|PILER-CR matches to NZ_CP044465 (Acinetobacter schindleri strain HZE23-1 plasmid pHZE23-1-2, complete sequence) position: , mismatch: 1, identity: 0.955

attttttacagccttagcaact	CRISPR spacer
attttttacagccttatcaact	Protospacer
**************** *****

6. spacer 4.2|1440163|35|NC_018607|PILER-CR matches to NZ_CP006909 (Clostridium botulinum CDC_1436 plasmid pCBG, complete sequence) position: , mismatch: 6, identity: 0.829

tcttctaa---ctgttttattttttctttatatttatc	CRISPR spacer
---tctaaattttgttttaatttttctttatatttatt	Protospacer
   *****   .******* *****************.

7. spacer 4.2|1440163|35|NC_018607|PILER-CR matches to NZ_CP044536 (Borrelia sp. CA690 plasmid lp54, complete sequence) position: , mismatch: 8, identity: 0.771

tcttctaactgttttattttttctttatatttatc	CRISPR spacer
ttttctaactcttttattttttctttaagaatttt	Protospacer
*.******** **************** .  * *.

8. spacer 4.2|1440163|35|NC_018607|PILER-CR matches to NZ_CP009059 (Borreliella afzelii K78 plasmid lp54, complete sequence) position: , mismatch: 8, identity: 0.771

tcttctaactgttttattttttctttatatttatc	CRISPR spacer
ttttctaattcttttattttttctttaagtatttt	Protospacer
*.******.* **************** .* * *.

9. spacer 4.2|1440163|35|NC_018607|PILER-CR matches to NZ_CP018745 (Borreliella garinii strain CIP 103362 isolate 20047 plasmid p_lp54_linear) position: , mismatch: 8, identity: 0.771

tcttctaactgttttattttttctttatatttatc	CRISPR spacer
ttttctaattcttttattttttctttaagtatgtt	Protospacer
*.******.* **************** .* *.*.

10. spacer 4.2|1440163|35|NC_018607|PILER-CR matches to NZ_CP028862 (Borreliella garinii strain 20047 plasmid lp54, complete sequence) position: , mismatch: 8, identity: 0.771

tcttctaactgttttattttttctttatatttatc	CRISPR spacer
ttttctaattcttttattttttctttaagtatgtt	Protospacer
*.******.* **************** .* *.*.

11. spacer 4.2|1440163|35|NC_018607|PILER-CR matches to NZ_CP009214 (Borreliella afzelii Tom3107 plasmid lp54, complete sequence) position: , mismatch: 8, identity: 0.771

tcttctaactgttttattttttctttatatttatc	CRISPR spacer
ttttctaattcttttattttttctttaagtatttt	Protospacer
*.******.* **************** .* * *.

12. spacer 4.2|1440163|35|NC_018607|PILER-CR matches to NC_017241 (Borreliella afzelii PKo plasmid lp54, complete sequence) position: , mismatch: 8, identity: 0.771

tcttctaactgttttattttttctttatatttatc	CRISPR spacer
ttttctaattcttttattttttctttaagtatttt	Protospacer
*.******.* **************** .* * *.

13. spacer 4.2|1440163|35|NC_018607|PILER-CR matches to MN692985 (Marine virus AFVG_117M57, complete genome) position: , mismatch: 9, identity: 0.743

tcttctaactgttttattttttctt-tatatttatc	CRISPR spacer
tcttctaattgttttatttcttcttctatggccgc-	Protospacer
********.**********.***** ***. .... 

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	1994918 : 2029773	34	Synechococcus_phage(16.67%)	tRNA,tail,protease,integrase,head,capsid	attL 2000422:2000439|attR 2017592:2017609

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_018607|1994918:2029773|DBSCAN-SWA
TATGATGAAATTAGTTATGGGACTTGGCAATCCTGGAAGTGAATATCAGAATCATAGACATAATGTCGGATATATGATACTTGATAAGGTTGCCAAGAAACTTAATGTAGAATTAGATATTAAAAAAAAGAAAACTGTATTTGGTAGAGCTAAATATGGTAAAATTGAATATCTTCTCTTAAAACCGCAAACTTTTATGAATCTTTCTGGTGAGGCTGCTTTATATATGGCTAGCTTTATGAAGATTGCTGTTGATGATATTATTGTTATATATGATGATATGAATATTCCTGTAGGCGAGTTCAAACTTGTAATTGCTAAAAATGATGCTAATGATAATGACAATGAAGAAAAAGAAGGTCCTATAAAACATAATGGTATCAAAAGCATAGAAGAGTCATTAAAAAGTAATAATTTTACTAGAGTTGGTATTGGTATAGGTACACCTGCTGAAGGTCAAGAAATAGCTGATTTCGTCTTATCCCCTTTCACAAAAGATGAAAGAAAAAAAATAAAAGATATAACTGATGATGTAGTTGATGCTATATGTAAGGTTTTATTTGAATCTAATAATAAAACATCTAAAAAGAAGTATCTATGACAAAATTAGTAATTGGGCTTGGTAATCCGGGCGAAGAATATAAAAATCATAGGCATAATATAGGTTTTATTATTATTGACAAATTAGCACAAAACCTATCTCTCAAATTCGACAATAACAAAAAAAAATCATTATTTACAAGAGCAAAACTTAATAACACAGATTTTATACTATTAAAACCTCAAACTTTTATGAATCTCTCTGGAGAATCTGCCATTTATATATCAAAATTTTTCAATATAAAACCAGAAGATATAATAGTAATATATGATGATATGGATATACCATTTGGAACTTTTAAGATAAAAAAAGGAGGAAGTTCAGGCGGGCATAATGGAATAAAAAGTTTAATAGCACAATTACAAACTGATGATTTTATAAGACTTAGAGTTGGAATAGGAAGACCAAGTTTTGGAAAAAAGGTTAATGATTATGTTTTATCTTCTTTTAGTAAAAGCGAAAGAGAAAATATAGATAATGATTTGGGTGAAAATGTAATAGAGGCTATAAAAACTATATTATTTGAATCATACACTATAGCACAAAACAAATATAATAAAAGAATAAATAATAAGGACACAAACAATGATTAAAATTGTAGCCAAAAACTATATAAAAAAAGATAAAAAAGATGATTTTTTAAAATTGGCTAAAGAATTAATAATAGAAAGCAGAAAAGAAGATGGATGTATAGCTTATGATATTTATGAAAGCATAGACGGATTATGTTTAACTTTTATAGAAGAATGGAAAGACGAAGAAGCTATAAAGTCTCATAACAGCAGCAATCATTTTATAACCATAGTTCCTAAATTAGCTGAGTTTCTTGACGGCGAAATGGATGTAACATTATACAAAAAAATAAATATATAAAAATAATTAAATATATTAAAACTTTTATAATTATAGTGTATAATCATTAATTATTATATTTAAGGATATTTATGATACTCAAAGAACTAACATTACGTTCTTTTAGAAATTATAATGAAAATACATTCGAGTTTTCAAAGCATATTAATATACTATATGGAATAAATGGTTGTGGAAAAACTAATATACTAGAAGCTATATATATTCTTGGAAATGGAATATCATTTAGAACTCGTTTAGACAGAGAATTAATAAAATATGGAAATGATAATTATTTTTTAAGAGGAATATTCAAAGAAGATGATTTGAATTATGACACTAATATAGAAATAGTATATCAAAAAAAAACAAAAAAAGTATTTATAAACAAAAAAGAAATTACCTCAAGAAAAAATTTAATAGGCAAAATACTTTATGTTATATTTCTTCCCAATGACACTGATATGGTAACATCAGAGCCTAAACTTAGAAGAGATTATTTTAATATGCTAATATCAAGCATTTCAAATGAATATCTTTTATCACTCATAAAATACAACAAACTTCTAAAAATGAGAAATATTTATCTAACAACAAGTCCAAATGATGCTCATATTTATAATGAAGATATAGCAAAATTATCTTTATATATTGCTAATGAAAATAAAAAATATTCTATGCTTTTAGAAGAAAAGATGAATGAAATATACAGAACTATTTTTAAAAATGATAACCCATACAAAATAAAATATTTATCTACAATAGAAGATATAGCAAATGAAAATGAATATATAAAAAAATTAGAAAGTACAATAAAAGAGCAAATAAAAATGCGTACTACATATTTTGGCATACATAGAGCAGAGTATCAATTCTTTTATAAGGATTCTCTATCAAGAAAATTTTCTTCTCAAGGTGAAAAAAGAATGCTTACTCTTATAATGAAACTGGCAAGCGAAAAAATATTATATGAATACAGAAAAAAATCCCCAATACTATTAATAGATGATGCTATGCTTGAACTTGATAATATTAAAAGAGAAAGTATTTTAGAATATATAAAAACATTAGGTCAAGTATTTATTACAGTTACTGAAAAAGAAAAGTTATCAAAATTTGAAGAGAGTAAAGTTTTTGATATTGTTAATATAAAAAATTAAATTTTTAATAAACTTCTTTACATTATAATTGTTTATGTTAAACTTATTATAAATAATCAATAAAAAACGGAGTGTTATATTATGGGATTATTCTCTAAAAAAATTCAAATAAAAGCACCTATTAATGGAAAATTAATTGATATTACAGAAGTAAAAGATGAAGCCTTTTCAAGCAAAGCACTTGGAGATGGAATGGCAATTATACCTTCTGAAGGTAAAGTATATGCTCCTGTAGATGGTGAAGTTATTACTATGATAGATACAAACCATGCTATAGGTTTATTAGCTGGAGGAGTTGAAATATTAATACATATAGGAATGGATACTGTAAGACTTGGCGGAAAATATTTTAAAGCTCATGTTAAAGAAGGAGATAAAGTAAAAGCAGGTACTTTGCTTATAGAATTTGAAAAGGAAGAAGTTGAAAAAGAATATGATATAACATCTCCTATAATAATTTCAAATTACAGCGAATTAAAATCACTTACAAAAACAGACCCAAGAGAAGTAAATACAACTGAAATTATAATGACAGCTGTAAAATAATTTTTTGAAAAATGAATTTATGAGGGGCTTTTAAAAGCCCCTTTTATTATATAATTTTTTAATTTTAATTATTGCCCACGCACCCCCACTTCTTTTGCGACCGAAGGAAGTGCCGGCGACCAAAGGGAGTCCTTCAGGGCGACCAAAGGGAGTCCTTCAGGGCGACCGTAGGAAGTACCTTTAGGTAAGGCGTGACCCAAAGAAGCAAAAAGACTGCATTTAATGAAGTATAGCTTTTGATGTATATACAGAATATAGACATTATTTTATATATCCAAAAATATAAAGCTAAAACATTTGCACTTTCACGAAGCGTATCTGAAGGATATAAGGTTCTTTAACGAAGTCCGCACCCCGTAAGGCGGGAAAAGAACAATAAATTTTTTATATTTTTTATTATATGTTGGAACTAGCTACAATTAATCAACATTATAATCTTTAAGCTTTCTGTAAAGTGTTGCACGCTCTATACCTAAAATCTTTGCTACTTGTGCTTTATTAAAATTGTTTTTGCTTAAAAGATGATTTATATATTTTTTCTCAAGCTCTTCTAATGTCATCTCTTTATCTATAATAAAATCATCTGTGCTAGATGTTAAAACCCAATTAGGAATATTGCTTTCATCTATCTTGCCGTCTTTAGACATTACAACCATAGTCTCTACAGTGTTTCTAAGCTCACGTACATTACCTTCCCATTGTAGTGAAGATAATAGTTTATATACTTTTTTATCTACATTAGTAATCTCTATATTATGAACCTGAGAAAACTCTTTAATAAAATTATCTATAAGTAAAGGTATATCCTCTCTTCTTTCTCTAAGAGGAGGCATTTCTATTTTTATAACATTAAGCCTATAATATAAATCCTCTCTAAACCTACCCTCTTTTATTTCTTCAGATAATTTTTTATTTGTAGCAGCAATCACCCTAATATCAACACTAATAGGAGTATTAGAACCTACCCTCTCTATCACTCTCTCTTCAAGCACTCTCAAAAGCTTTACCTGAACAACCTGATTAATCTCCCCTATCTCATCTAAAAATATAGTGCCTTTATTGGCAGCCTCAAACCTACCTATTTTTTTATCTATTGCACCAGTAAAAGAACCTTTCTCATGACCAAATAATTCACTCTCCAAAACACCCTCAGAAAGTGCAGCACAGTTAACAGTAATATATGGCTGTTTGGCTCTGTCTGATATTTGATGAATTGCATTAGCAACTAATTCTTTACCAGTTCCGCTTTCGCCTTCTATAAGTACAGTAGCCTTTGTTCTTGCCACCTGTTTTATTGCTTCATATACTTTAAGCATCTTACTGCTATGACCTATCATTCCATAAAAACTTTCATGATAGTCAACTCTTTTTTCTAATGTTTCATTTGTCTTTTTTATGTTTTTATTTTCTAATGCCCTTGCTATAATAAGAAGCATTTTGTCTATGTTAAAAGGTTTAGTCATAAAATCATAAGCACCAAGACGCATCATATCAACAGCTGTTTCTATATTGCCATGCCCTGTGAGTATTATAACTGGTATATGCTTATCAAACTCTAATATGTCATGCAAAAACTCTTCGCCAGTCTTTTCAGGCATTTTTAAATCTGTAATAACTAAATCAATTCCGCCTTTATAAACTGTCTCTATTCCCTTCTCTCCATTCTCCGCAGTAACTACTTCATATCCCTCATACTCTAAAGACTTCTTTATACCGTCTCTTATGTTTTTCTCATCGTCTATAACTAATATCTTAGGCATAAATTAAAAATCACTCTCCAAAAATTTTTGATTCTCAAGCATCAAAGGAAGTTTAATAATAGCCTCGCTTCCAAAACCATATTTGCTCTCTATATTAAAACTGCCATTATGTGCCTCTATTATTCGTATAACATTCGTAAGTCCCAATCCTGTGCCGTTTCTTTTGGTTGTAAAATATGGCTCAAATATCTTTGATAATTCTTCCTCTTTTATACCAATGCCTGTATCTTTAATTGATATTAAAGCATAATTATCTAATAATTTTAACTTTATTGATATATTATTCTCATCTGATTTATTATGTTTTTTCTTTTCTATAATAGAATCTATTGAGTTTTGTATTATGTTAATTAAACATTGTTTTATATATTTCTCATCTATTTTTAAAATTAAATTTTCTATATCAAATTTTATATCTATTTTTATATTATTATTTTCTATTTCATATTTCAAAAAATCAACAGTAGAAAGTATCAAAGAGTTTATATTAATATCTTCCAAATTAAGAACTAATTTACGAACAGAAAATAAAAACGAATTAATGGTATCTTCAAGCCTGCTAATCTCTTCTTTAATAATATTACAATAATCTCTAAACTCATTATAACACTGGCAATCATTGTCAATATTTTTTTTAATAATTTTCTCTATCAACTGCACATATATAGAAATAGAGCCTAGAGGATTTTTTATTTCATGAGCAACCCCAGCTGCAAGCGTTGTAAAAGAAGCTAATTGTTCAGCACGTTTAAGCTTCTGAGCACTTTCATAGCTTTTTGTAATATCAAATATTTTTATTAAAGTTCCTATAATGATTCCAGAATCTCCAAGTGGCAAAATATCTATTTGAAGCATTCTGTCATTTTTATCATCTTTTATAATTTTCGTATCTGTATTATTTGCTTCTAATAGTTCTAATATTAATCTTCCTATATTGGTGTTATTTATACATTTTGAAATTGCTTTATCTTCAGAGTTTCTTGGTATAGATAACAAAAAACATGCTTTTTTATTTATACCTTGAATTATACCGTTGATATCTATTGCTATTATGCCTTCTTCTAAATTCTCTATTATTATATTTTGAGAATTTGAAAGTAAAGCTAATCTTTCAATTATTCTTTTCTTTTCTATATCCGAAACTTTATCGAAGTTTTTTATTATCTTATCAAAAAATTGATTTCTTCTATTCATTCTAAAAGTATAATAAAAAAACAAAAAACTTCAATACTAATATTTAATTAGAATATTACTTTTTGCCACTTGACTATAAACAAAAAGTTTATTATTATATAATAACTATTATTAATAGAAGAAGCGGATTTTACGAGGAGTATAAAAAATATATGATTAGAAAATTAGTAATTTACGGAGACGATAGATTAAAAGAGAAATCATCTTACGTAGAAAATGTAGATGAAGAGATTTTAACTTTAATAGATGATATGTTTGAAACTATGTATAAGGCTAATGGGGTTGGACTTGCTGCCGTACAGGTGGGTGTATTAAAAAGAGTAATAGTAATATCTGTACCTGATTTTGATGATGAAACTAAACCTGATTTTAAGTTGGCTTTAATTAACCCTGAAATAATTTGGCATGGAGAAGATACTGAAATATTAGAAGAGGGCTGTTTATCTTTTCCTAAAATAAGCGATGAGGTTGCAAGATACAAAGAAATAAAAGTAAAATACATAGACACAGAAAATAAAGAGCAAATATTAGATGCTAAAGATTATATAGCTAAAGTTCTTCAGCATGAAATAGACCATACTAATGGGATTACTTTTATAGATAGGCTTGAATCATATCAAAAAAGAAGATTAAAAAAAGATTTAAAAGAGCTTAGAAACACTCATAAAAAAACTGTTTCTGCATAAAATATGTTATGATAAAAAATATAATATTTGACTTAGACGGCACATTGATAGATTCCATTCCAGATATAAATGCCAGTGTAAACAAAACTTTGGAACATATCAAATTTCCAAGTTTAGATATAGAATACACAAAAAAATATGTTGGCAATGGTGCTAGGCTTTTAATAAATAGAGTATTAAATCATTTTGCTGATAAATATGACAAAGAATATTTAGAAAGTATTGAAAATGATGTGTATAATTTTTATATTGATTATTATAGTAAACACTCTACAGACAATACAAAGCTTTATGACAATGTATTAGAAACTCTTACATCACTTTATAAACTCAATATTAATATGTTTATAATATCAAATAAGCCAAACGAGATAACAATTACAACAGCAAAAAAACTAAATATATTTAATTATTTTAAAGCTGTTATAGGCGATGGAATCTATCCTTATAGAAAGCCAGATGTGAATATTTGGTATAACTTAAAAAGAGATTATATCCTAATAGAAGAAGAAACTATTATGGTAGGAGACGGTGTTCCAGATTATGAGTTTGCCAAAAATGCAAAAATAAAAGCACTAATTGCCTTATACGGCATTACAGACAAACAAACATTACTAAATTTAAAAAATGATTGTTATATAAACAGTTTCAAAGAAGTAGAAGATTTCGTATTAAGCAGCAACAAGTAAAATTTTCTATACTTTCTACCGCACTGTGAATTAATAAAAATATTTTATTCTATTTATAAAACAATTTTAATTATATTTTTAATCAAGCTCAACGTGCGGAAATGTAAAGAAAAATTTTGAGTCTCTAAAAATTATATTTTTTTAATATTTGCGGGTACTAGCCCCCGCTTCCCCAGTTCTTTTGCGACCGAAGGAAGTGCCTGTGGTATTGGCACAAAGAACCAAAAAGACTGCATTATTAGATTATATTTAATATATATATTATAAGTTATAGTTTAATGAAAAGTATATAAGAATAAAACTTTTCACATTCCAATCAAAGCAATAGAATGTTTTAAGAGTGAGAGCAATAAAAATTTAATATAGAATGCTTTTTGATAAAAAATAAAATTAATGAAAGTTATGTTTTGAAGTTTAGAACAAAAAACCTTATAGGGCGGGGTGCGTAAATAATTTTAAAAAAAGAGAGACTCTTGACTATTCAAAAGCCTCTCTTTAATTTATTAGTTTATAATATATTATTTTTCAGTGTTGTCATAATAAGCATAGAAAAACTTATGCTTACCAAGCACATCATACTGAACATCTTTTAAATTATTATTTACCAATAAAGGCAATGTGTAATAATATAAAGGAATGATAGGCATATCTTCCATAAATAATTCTTCTGCCTTATGAAGCAAAGGCATTCTTATAGTATTGTCATCTGTAGCAGAAGCATTAGCTAATAATCTATCATATATAGCACTATTATAACTTTCCACATTTTGAGGACTGTAACTTAAAAACATACCTAAAAAAGTCATAGGGTCATCATAATCTCCAATCCAACCATTTCTTGCTATAACATAAGTTCTGCTATAGCGTGATGATTGAAATACTGCCCACTCTTCACTTACTATAGTAGTATCTATTCCTAAATTATTTTTCCACATCTGCTGAATAGCTTCAAATATAGATGTATGCTCACCTGGATTAGTTTTAAACTCAAGTACAGGGAAATTTTCTCCGTTTGGATAGCCTGCTTCAGCTAATAATTTTTTAGCCTCTTCTATATTTTTTTGATAATCTTCAGCCTTTAAACTAAAACTATCTTGTCCATTTTCTCTAAACTTCCCAGTAACATCAGATATTTGAGGCGGTACAACAGCAGCAGCAGGAGTTTGCCCTCCTCTTGTAACTTGAGATACTATATAATTTCTGTCAATAGCCAAAGCTAATGCTCTTCTTACTCTCTTATCTTTTAATGTTTCATTAGTAATATTTAAACTATAATAATACAAACCAAGGTAAGGTTCTATTTTTAAATATCCTTCTTCTTTTAATGTATCCATATCTTGAGTAGGTACTCTATCAGAGAAATATATAGAACCGTCTTTTATACCAGCAACAACAGAAGTAGGATTATCCATCAATATAAAAATTAATTTCTTTGGAACTATAATAGAACGATTCCAATAATTAGTATTAACTTCCATTACTATTTTACTGTCTATCTCTCTTTCAGTCATTTTAAAAGGACCATTTCCAATATAAGTATCAGCACTCATAGTCCAAGTATCAGGATTAGCTTCTATAATATCTTTTCTTAATGGGAAATATACAGGATAAGCCATAAGCTGGTCAAAATATGGAGTAGGAGCTTCCAAAGTAACCTCTAAAGTATTATCATCAATAGACTTAACACCTAAAGATTCAACAGGCATCTCACCAGCAGTAATCTTTTTAGCATTTTTTAAAGGCTCCATTTGATAACTATAATTAGCAGCAGTTTTAGGGTCAGCAGCCCTTCTCCAGCTATATACAAAATCATCAGCTACAACAGGCTTACCATCAGACCACTTAGCATTGCTTCTAATATGAAACACATATTTAGTGCCATTCTCACTAATATCCCAACTCTCAGCAACACCGCCTACAATTTTACCCTCTTTATCTTTCTGTGCTAAACCCTCAAAAGCATGTATTATATACATACTTCCGTCTATTGCAGAGTTTAATGTAGGGTCTATACTTTGAGGCTCTGGCCCAACATTCAAGCGTAAAACTCCTTCTTCGAATTTATTTCCGCCTCCGCAAGATGCAAACAAAAACAAAGAAGAAATAAATAATAATAACTTAATCTTCATAATAATAAAAAGACTCCTATATTTTTTATGTTTGATGATTTTATAATGATTTATAGTAAATATCAATATTTTTTCATATCAATTTATCTAGTATTTAATTGAGTGAAAAATAATTATATAGTTATTTTTTTAACCTATTAACCGCACGGTAAGAAAATTAAGAAACAAAAAAATTCATATTATAGAAACATCTATATATAATTTTAATAAATACAGCGTGCGGCATTTAAATACTAAAATAATCTTTTATAAATTAAGAAATAAAAGAAATATATAACAAGAGTAAAATATAAATTTATTTAACTAAATACTCGCCATCATCATTAAACTTAACGCCTGTCTTTTGAAAATCTAAATCAGCGTATTCATTTAATTTTTTTATAGCAGTATTTGCAGAATCAACACTAGGTATGCCGCCATTTACTAAACGTACAGGTATAACTTTTGCTTTAGAAACTTTTAAATCATCATCTAAAGTAATTTGTAATATAGCACTAATTCCATTATTTCCAGACAAAGAGAATTGTTTATATCCAACAAAATTTCCAAGAGAGTAAGCAATAAAAGTATTATTATACATTTCCATAGCTCTAAGTACATGCGGACCATGACCAACTACTAAATCAGCTCCCGCATCGCTAACAGCCCTTGCAAACTTATAAACATCTCCCCTATTTTCTTTATAAAAATACTCAGTTGTTTTAGGTACTCTAAACATACTGCTTCCCTCAGCTCCGCCATGAAAACTTACAACTAAAAAATCGCATTCTTTTTTTGTTTTTTCAACTAAAGCCTTAGCAGCTGCAATATCCTGTATAGAGTTATTAGCATAAGAAAAATAATAGAAAGCCAAAAATCCTATTTTTTTACCCTTAACTTCTATAAAAGAAGCCTGATTTAAAACATTGCCTACAACTTCCATACCAGCTTTTTTTACATATTCTTGAGTCTGACTATAACCCTTAGCACCAAAATCTCTAGAATGATTATTAGCAACAGCAACTATATCAAAACCAGCCTCAGATATTCTATCGGCCATATATGGGGGCATACGAAAAGAATATGAACGCTTGCCTGTTTTAGCAGATTTTGTTTCTGAGTTTGCTATAGCCCCTTCTAAATTTGCAAAACTTATATCTGAAGCTTTTAAAAATGATGATACACTTTTAAAAACATCTTTTCCTTCATTAGGAGGCAAATAACTTTTATCTGGATGGTCACTTCCTGTCATAACATCGCCTACAAAAGATAATGTTATCTCTGGATATAAAGAAAATTGGAATAATAATATTAATAATAAAGTAAAATTTCTCATAATAATATGATTTTACCATAAAAATAAATAAATTCAATATTATGTTTACAAATTATATTAAAAGTTTTTTCTTTTTTACCGAGTTAATATAAAGTTAGATAATATTTACATTTTATATGCTTGACAATATATAAAAATTTAGTATTATACTAATAACAATTTTAATAATTTAATAATCTAAAATTAATAAAAAGAACTAACTGCCATGAGAAAATTTAAATACACAAGAGTAAGAAGAAAACAAAATATTATAAAGAAAATAAAACAATATTTAATAGAAGATAGTGATAAAAATCTTTTTCCATATTTTCTAAAAAAATCATTATTAATAGCTATATCATTTATAATGTTCATAGTTTTAATTAACTTTTTAATACTTGGTTCAAAAAGAAATCCTAATAACAATTTATATGCTCAAAACACAGATAATTCAAAAAGCACATCTGAAGTATATAATAAAATATTAGATGAAGTAAAAGAAATGAAAATAGAAACTAATAATATTGTTACAGAAGAAGATATAAAAGACATACCAGCAGTAGCTTCAACTCCCGTTGCTTCTGTAGAAAAGGCATCTGATGCTTTTTATGATTATTTGGTTTCTGATAATTCTCTTGTGAGTGATGGTACTATTAGTCTTAAATATGATGAATATACAATAGAAGAAGGAGATAATTTAACTAGCATATCAAAAAAAATAGGTGCTAATTTAGATACTATAGTTAGCGTTAATAAAATAAGCAATGCTAATAAATTAAGACCAGGACAAACTATAATGATACCAAATAGAAATGGTTTGCTTTATATTGTTAAGAAAAATGAAACATTAGAAGAGATTAGTGACAGATACGATGTTGAACTTAATAGAGTGTTGAGCTTCAATAAAATAGATAGAGATAACATTAACACTGGTGATGAAATATTTTTACCAGGTGCTAAATATACATTAGATGAAAGAATAGATAAGTTTGGTCAAATGTTTAGCTTACCTACAGTTGTAACAAGAATAAGCAGTGTATTTGGATATAGAGTACATCCAATTACAGGGGTAAGAAGAAAACATTTAGGTGTTGATATACCTGGCGGATTAAACACTCCTATATATGCTGCTAGAAAAGGAAAGGTTATATTTGCAGGATACAGCGGCGGATTTGGAAATTTGGTTATAGTTCGTCATGATAAAGGATATACTACATATTACGGACACTTAAATAAAATCACTACTACAGTTGGTGCTAATGTAGGTGTGGGTGTAATGATAGGAAGAATGGGAAGCACTGGTAATTCTACAGGAAGCCATTTACATTTTGAAGTGAGAAGAAACGGAGTGGCATTAAACCCTGCAGACTTTATACCTATAGGAAAATTCATTAAAAGAAGATAATTAAAATAAATAATCTAAAAAATAAAATAAGGAAACAGTAAATAACACTGTTTCCTTTTTTGTTTATATACAGTTATTGATAATAACATATTAATAAATATTTTAACGAATTTTAAAATCAAAAAGATATATAGAAAGCGGTACAAGGCTTTATTTTTATTGACAAGTAAAATACAAGCAGGACATAAACTATTTGAGAGATAGTTTTTCACACTTGTACCGCATTTCAAGCTTATTAAATTAAAAGAACTATTACATCTTATTTTCTTCTGAGTATACAACTCTTTAGAAGATAGTATTATACCTCTATCGCCTTTCATATTATGTCCTTTAATGCTTCAAAAGTTTCTCAGGCTTTTGTTCTTGATGCATTTTTAATTTTACTTGTCAATTGTTAATATACACAAAAATAATTTTAAAGTCAAGAAAAAGATATATTTTTTTAAAAATTTAAAATACGGCTATAAACGGCGATTTTTGAAAGGGTATATATAAATGTATACCAAAGTAAAAAAGTCCCTAAAATGAGGCTCTACGCTTCAAATAAAGGCATTGTAATAAATACTCTATCAGCAAAATTATATTATATTATCGCAATAGCATTAAAATATTTTTTTTTGCTTTAGCTTTTATTCAAAAAAATAAAAATCTGCATAAGTTAGTTAGTTTAAAGTCTTTAAATAAATCATTAGTTAATATTTAAAAGTCTTTAAATATATCTTTAAACTCATATATCAAAATGCAACATGCCTATGTCGCAAAATGCAACATGCCTATGTCGCAAAATGCAACATACCTATGTCGCAAAATGTAACATACCTATGTCGCAAAATGTAACATACCTATGTCGCAAAATGCAACATGCCTATGTCGCAAAATGCAACATACCTATGTCGCAAAATGTAACATACCTATGTCGCAAAATGTAACATACCTATGTCGCAAAATGCTACTTTAACCTATATATATGCAATTTTTTTAAGCCTTTTTTAAATCTGTTTCTCTGGGCAGATGATTTATAATCTCATTCATTTTTTGAGATAAATCTTTCCACTCATCAAGCATATTTTTTATTGATTCAGCTTCAGCACTTTTTATATTTTTATCCGAATTAGTACAGTCTTGTTTCGTACTATTTTGCTTTTCTCTATTTTTAGCAAATGGATGATTTTGCATAGCCTCTTTTATCATGCTAGCCATAACATAAATATATCTTGATACTGTTGTATTAATATTTTGATGCCCAAGCATTTTTGATATTACATAAATGTCTGTTCCGCTTTCTGCCATATCAGTTGCAAATCCTCTTCGTAGAGAATGACAGGTAACTTTTATATTTGTCTTTTTAGAGATGATATCCATTATTGTGCTTATAGTATTTATGTTCAGAGGCTCACTATTTTTTTTAATGAATAACATGTTATGCTTTTTATTTTTACGACTTAATCTTTCTTCTCTTAATTTTAAGTATTCAATTAATTTAGATTTTATTGAATCAGAAAAAGAAATAATTCTCGGTTTATCCCCTTTCGTTTTATAAATAGTTATGGTATTATTATTCATATTGATATTTGTTATGTCTATGCAGGCAAGTTCTTTTCTGCGAATGCCTGTATTAGACATAAGCAAAAGCATAAAGATATTTCTTTGATCTAAAAAAAATAGATTTGGTGATTTTGATTTTTCGGCTATTGCTTTTGTGATAGATAAAGTTTTATCGGCTTTTATTAAGAGTTGTTTTTTTACAATTATCTTTGGAGTTTTAAGCTCATCAAAAATATCAAAAAAAGTTTCTGTACTTATTTTTTTTAATTTAAGCAAATATTTAAAATAATTTTTGACTGCCATTATCATGCAGTGAATAAAATCAGCACTTACTTTTTTATTAACTTGATAAGCTATATAGTCTTCAATGCATTTTCTATCTACTTTATTATACAGTACCGTAGTATAGTATGATTGAGTATTTTCAGATTGTCGGTTGTCATAATAAAAAAATAAAAAATCATAAAATCTTTTTATACAACTTGAATAAATCTGTATAGTTGCTTTTGATTTATATAGTTTAGAATATTCAAGATATTGAATAATTAAATTAGAATTATTATTATCATATAGTTTTAGACATTCTATTGTTTTCATAAAAATAGCTCCATTTTTTATTAGGCATATACATGCCTAAGTTAAAAAAGTTTGGCAACGTTTTTTATAATAAAAACAGAGCTATTTTATATTTACATTTATTATCGGTTTACTAAAATAATAATTTATCTATCATTAAAAATATTTAATATTTCTTTACTCTCTATATCTTCTGCTGTTTTATAAGGAGTTATACCATATTGATGTTTTGCATAAATATCTGCACCATAATTAACTAATTCAATTATTATATTTAAATCTTTTTCATTAGAAGAACTATAATATTGCCATATTGCTATCATTAAAGGAGTATTACCATTTTTATCTCTTATCTCTATATCTGCTCCTAATTCTAATAATTTTTTTATTAGTTCTATATTCCCTCTATATATGGCATTTATCAATAAAGTATCATCATTATTATCTTTAGCATTTATATTAGCACCAATTTTTACTAATATTTCAAGTTTTTTATAATCTATATTATAAGAATTAATAAAACATAATAATGGAGTGTTCCCTTCATTATCCCTAACTTCTAATTGAGCTCCAGATGATACAAGTTTTTCTACTGCATCATAACCAACAGTAAATAATGCTGTTTTTCCATTAGTATCTTTTGCATTAACGTCAATTCCTAGTTTTATTAATTCAGCTGCTATATATTTATCTTGTGCATAAAATAATAGAGTTCTTCCTCCTTCTATATTTATGTCAGCATTATTATTTATAAGTTCTTTTAGAATATTAAGATTTGTTAATGAACTAGCTAAAACTATTGGTACAGTAACTATATTATAAATTGATTCGCCATTAATTCCTTTATATCGAATAGTATTTGTAACTGCTTTATTAACATCGGCACCTCTTTTTATAAGTTCCTTTACTATCTCTGTATTTGATATCATTATTGCATATATTAACGGTGTATATGCCTGATTAATAACACTATTAGTAATTATAGTATTAACATCAGTATTATTTTTTATTATTTTTTCTAAAATAACAAGACTTTCTTTATCTCTTGATTTTAATAAATTATAATTTTGAGCCAATAAATTAAAACTTAAAATGAATAATATTAATAATATTTTTTTCATAATATACATCCTATTATTTTTATTTAATCATTCTATAAAAATGAAACAAAAAAACAACAATAAAAAAGTTAATAAAGGTTATATTTTTTATTTTATTTATGTATAAAGTTTTTCTTAAAAAGAAATCTGCTAATTATAATTTTTTTAAAAAAATAAGCAGAACTAATTAATATTTTCTTATATTTCTTTTTAATACTATACATAAAATAAATTTTGAGGAGAGCATTATGCAAAAGTTACAACCTTTCAATAAAGAAGAAAAAAATATAGGAATAACTTTGAGAGTTACAGAAAAAACATTTCAAGAGATGAAGAAAGAAGCTTCAAGTTTAAATATGAGAGTAAGCGAGTATTTAGCAGAACTTCATAAAATGTATATCAATGAAGTACATCAAAAGTAATAAGCTTAAATAAAAAAGCGGGTAAGATTTTTGCACAACCTTACCCTTGAAAATCAAAATATCACTTGCGAGGTAATAAAATGATTAGTATAAATATGATACTACTGTTTTTAAAAATAGTAAAGTATATTTTAATTTTTTTATAAAAATAATTAATAAAGATAAATATAAAAAACTTCATTGCATATTAAATAAGGCAGATTCTTTTTTAACTCTTATTGTAAATATTTTATCAATAATTGATTTTGATTTATGAATATTTATAAAATATTAAAGGCAATTATAGTCATTGCAGATACCATAATTTCCTTATACAAAATCTTTAAAGAATGAACAATAATCTAATACTTTGTTTTCTATAAGATATACTTGCAGTGTTATCAGTTACTATTTTATGAAATTATAATTAAAATATAAAAAGTTTTTTATTCTTGTAGTTTATATTATTTTTAATAATAATTGACAAGTTAAATATTTATTATATTATTATTTTTATAATAATTTCTATTTCTTTCTCATATCTATTTTTATGTTTTGTTGCAATACTTAGTTGTAGCAAAACATAAAAATATTTTTAAATAAAAAAGGTTTTATTAATAAGAGTAGTTTGTTAGATTATAAAAAATTATTGATATTATTGGGGAGCTAACAGCAGAAGCTTTTTTAAGTTACTGCTATTAGCTTGCTAAAGAAAAAATATTAAAAAAGGAATAAATGAATAACAAAGATATTAGTATGAGATGAATATAAGCTTTTATGGAGGTGGCAGCAGGAGCTCTTAAAAACTCCAACTGCCCTATAATGAAGAATACCATATTAGAAGTTGCTGTGTAAACTAAAGATTGAGATCATACTAATATATTAATATATGTTAAATATAAGTTTTTATTATTATACTAATAATGTTGTAAGTTAAAAAAGTTTTTTATTTTTAAAGAATCATTTATAAATTATTTATCTCCTTCAAACTTAGCTTGATAACTTTTAAAACCAGCAAGTCCTAATAAGCCACCAATAAAAAAAGGAAGCGACTCTATAAGCCTCTCATCTTTAGAAAAAACTAAAAAAGATACACAAACAAGCATTACAGTAGAACCTAATAAACTTATTAAACGCATAGATGATAAATGCCCTGTTTTTGAAGATGATATTAAATCTTTAAAACAATTTAACATAAATGAATCCTTAGAAATAAATAGTTTATAATATCATAGCAATAAAAAACATTACACTTCCATAAACTAATCTAATAAAATAATATATTGATGTCTTATTTTTTATAAAAGCTTTTAATCTATTTTCATAAGTTCCAGCATACGCATTCATGAACTTATAATAATATTTGCCTAGAGATATAAAACTATAAAAAACTATAATTCCTATTAAAAAATTAAAATTAATTTTAACATATAAACTCCTTTTATATTTGTTTAGGTAAAACCCAATCTATATTATAAGTAGTTCCAGCATTTCCTTGAAACTCTAGCACGCACATAATATTATTATTTCTATGATAAATTGCTTTTAAAGTGCCTTCATTTGTATTAATACTATATTCTTCATTATTTTCAAAGAAATCTGAAATACCATTATTTGTAATAGCAGTAAAATTAGTCTCTTCATTTGAGAAAGTTAATTGCCCTTTTATTTTATAGTTTCCATCTTCATATACTATTCCAAAGTCATCACTTACTTTTGAAACCGATATTTCATTTACAACTTTATTATTAAACAATACTATATTAGTATCTATTAATTTTATATTATCAAAACTTTCCTCAATAACAGGATTTTCATTTATTTTTTGCATATTGAGATATATATAATTCTCATGTGCTAAACTAACAACATATAAATTATCTGTAATTATAGCAGGTATAATATTTTTTATATTGCCGCCTATTGTATTTATTGTATTTGTAGTTTTTATTATCATACAAGATGATCTATTAGTATCTTCATATAATTTTATATTTCCTTTTAAGCTATAAGAATTATCAGCATTTTTTACAAGCGATAATTTACTGCAATCTTCTACTTTATTATCAACCATTGGAGAATTGAGAAAATATGAAACAATTTCAAAATTAGATACTTCTTCTTGAGGCTCTGGTTGTGGTTTTGCTTCAAAATAATCTAAATCTATATCTTTATTTAGAGCCTCTATAGCATCTTGGACAGTTTCTATTACTTTTTCTTTAACTTCTACTTCTGCATTTTTATCTGGAATCAAATCAAACATTATTATTTCGTCTGCTTCTAATTCAGAACCATCTTGATTAACTATTTTTAAATAATAAGTATTAGCTTTATTTTTATATCTCATAAAACCAAACTTTTTAGGTTTCCCTGAACTTGAAATAATTCCATCAGTATTTATTAAATTATCGTTACTGTCAATAATATTAAAATAATTTTCTAATATAGGACTGTAGCAAGTAGGATGAATTAAACTACTCTTACAAATATAATGCCCTTTGAATCTTATTTGATTATCATCTTTTTTTACTATTTCAAGTTTAAAAGGTGTCAAGCTGCCTATTAATAGAAAATATATGTTTGTATCTAATTTATTTAATTGCTTGTTTTTAATGTCTAAAACAATGTTATAATTGCCTTCTGCTATTTCAGTTGGAAACTCAGCTTTCGCAATAGTTAATAATAATTCAGTAGATTGAATAGAAATATTAAATACAAGAGTAGAATCTATATTAGATATTTGGCATTCATTTGGAGCTAAACGATATATCATATTATTTATATTAAAGAATTGTGATAACACATTATATTTTAGTTCCAGTTCTTCCTGACCATTAACACTTTTAATAATTAGACGTACTATTTTGTTTACATGACAATTACTAATTATAGCTTTAATTCTATAATCGTTTCCTTCTTTTTCTATAACAGCAGTATATTCATTAGTTCTTTCTTCATCAGTTAATACCAAATTGATAGTTTCTATATTTGTTTTAAACTTTGGAAAATTATATTTTTTATATGTTAATTTAGCTTCTTCATTGTCAAAAGATATATGAGAAGCTGTTAGAGCTTTTTTGTTTAATATGCCATCTAAAATATCTTTTAATTCTTTAATATTAGATACAGGAGCTTCATTAGGTTTGCCGCCTTTTATTTTTTCTATATTTGCTATTATCTGATTATGATCTTGAGCATATACAGTTTCACCATCTTGAAGAGCTGGCACTTCTTTATAATTATCAGGTTTTTCTAATTTTTCTAATGACATAATGAAGCTCCTATAATTCCTATTTTGGCATTATTTTTTATAGTAAAAATAATTTGTTCCAACTTGGGCGTTGTACCATATTTGCCACTCTCCTATTTTTATAATACTCTCTTGATATCTTTTCATTAAATCCTGTCTGTTTGTAGCTTGTTTTATAATGAATATTTCTGGAGGAGTAGAGAGCGGTATTTTTACATATTTTACTTGTGCTTGACAGGAAGGTAATATTATTAAAATAATTATAAAAGTTATTAGATATGCTATTAAATGTTTCATGTTCTGTCCTTGTTAGTGATTCTTTATCTATATTTTTAATCATAGCATCTGAATTACTAAAGCTATTTTGCAACTTTTGATTTTCCTGTATAAATTGTATTTCACTTTGAAGCGTTTGAGTTTTAAGCTCCAAGCCATTAATATTTTCTTGATACTCAGCAATCTCTTTTTCTTTCTGACGTATTTCACTATCTTTAACAGCCATTAATATAATAAAAATAGCTACGAAAAGAACTATTCCAATAGCTATAAATATTCTCTTGTCTATTTTGCTTAAAAAAGCAGTTATTATTGGCATCATGTTAGCTCCTATTATTTTTTATTATTTAGCAAAATGAATTATAAAACCTATTATAGTTCCTAATCCTGTTAGGACGGCAGCAATTCCCACTATAGCTTTACGAATATTACTTAAAGTGTTAATATTGATATTACCTTCTAAACTCTTTTTTATTTCTTTTAATTCATCTAAAAAATCTTTAATTTGAGTTTCCAGTCTTTCTAATCTAAAATCTATTTTAATTATATCTTCTGATAAATTATCTAAATATGTATCATAACTTTTTATATCATCGCTGAGGTTTTTAATTTGTTCTTTTACCTCTTCTATTTTATGTATAAGACCGTTGCCATTTTTTGTGCCATCTTCATTTATACCAACAGTATGTTCCACATGCATTAATCTTTTTTCAAGAGTACTAATTGTATTTTCTTGCGAAGCTGTTTGAGTTGTTTTTTTAGGGGACATTTATTAACCTTCTAATATTTTTAATATTTTTTTATACCTTTCTTCTCTGTCTTCCAGTCCGTTATATCCGCCATTAATAAGTTTAGTAACACCCTTCACATCTCCTTGACAAGCAAGTAAACTGCAGCCTCTCTCCTGCCAGAATAATAATGCAATCTCTATTGCATTGTTTGTTTTTTTTGCTAAATCTGGATTATTAACTAAATCAACATTTATTTTTTTACCATATTTCTTATAGTTGCTTTTTCCAGTAAGCTGTATTATTCCTCTGCCTCTATATTTATAGCCTTCATCTTCAGCATTGCCTAAACGTCCGCCATAAACAAAATTAGCTATAGCTTCAGCTCCTTGAAGACATAATTGTTTAGCATTTTCTAAACTTCCAACTCTTTTTCTAAATACATCATAAAGTCTTGGCGGAGTATATTTGAAGCTCTCTTCAAGTCTTTTATAATTATTACTTTCATGAGTTGTTTGTGCTAAAAACATTGCAGCTTCTTTAGTGTCTGTAATATTGTATTTATTAAAAGCATTATTTAATGGATCAAGCCATTTCTTATTTATACCTATTTTTTCTAAAATATTTTCATTAAGCATATAAAATTACTCCTTATCATCTTCTTTGGAATCATAAACTTTTATATATTCTGTTGTTTTAGATACATTTGCTATTTGAAGTGTTTGTTCTCTTTTTTTAGAACTTTAATCTCTATTTCTATATTTTCTATAGCCTCGCTATATTTGTATGTTACTGCTTCCTGTTTTACAATATTGTGTCCATTATATTCTATTTTATTGTCATGTGCTTTTAATAGATTAATAACATCTTCTTTTATAGCTTCAATATTTTCTTTATTTTTTTTCTCTTCATCTTTTAATTTGAGATATTTTTCTATTAATGCAGTTTCTTTTTTAGTAAGTTCTTTTACATCAGTTTTTGACATAATCTATCCTTATATCTTTATTTATACCTATTAATGAAAAATATAAGGATAATTCAAACTAAATATGATAAAACTGCTACAATACTATCTTTTAAAGATTTTTTTATATGTTCTAATTTCTGTGAAATACTGCTTTGGCTGACATTTAATTTTTCGCCGATTTCTTTTTGAGTATATCCATTGGAATATAATTTTAATACTTCTATATGATCTTTAGGAAGTATTGCAATTATAATACGTTTCACATCACGTTCTTGAACTTTAGATAGACCATAAGTATATAAACTTAAATCTTCAACATCATCTATATTTTTATCAGAATTATAAGACGTCATATCTAAGTATGATAATTTTTTGCCACTAATTGTTTGTAAATGCTCTATCATTGAAGGACATAATTTAGTGCATTTTTCTCTTTTATCACAAATATTGCAACTTATATCTTTCATAACCTATTATCCTCCATATTCATATAATTAGCTATTTCAATTGCATCTCTTACAGAAAATGGTTTTTTAATATTAAGTTTCTCAGCTACTCTTTCTATATCTGCTTTTAATTCTATGCAATTATAGCAATCTATTCTATATGCTATATCATCTGTATCCATTTCGCTTATGGCTAAAACGCCCAATGATGTCATTATATAAACTCCTGTTTTTATATTTGTCTTAGCTTTATTACATTATCAAATATGTTTAATTTGATAATTTCGCAAAGACATGGTTTTATATAATAACTTCCGTTTTCTCTTTCATATTCTATTTCTACTATATCAAATAACTTTAGAAAATCTAAAGTTTCATAATATTCAAATGTGTAATATTCTTTTAGCAAGTATCTGCTTTTCATTATTTCGTTAGATAAGCTAATAGCATCTTCTTTTAGTTTTAATAAAGTTTCAAACTCTTCATGAGCATTTATTCTATGCCTCTTTTTAGCTTCTTCTTCAAACTCAGTATTTTTATATGTTGATTTTAATAAATCATATTTAATACTGCAGCTTGATAAATACTCATCGCTTTCTACTGTTTTATCAATCCTGCCCATGCAGTATTGTTTTAATTTGTATTTAGCTTTATTCTCACGAAACCTTGTACTAATAAAATCTATTTTATTATCATAGACTTCTAATCTTCCTTGCTCTAAAAAAGATAGTTCCCCTATTAAATCAAGTGTAGTCTTTTTGTTATCATTATCAAGAAGAACGGCTATTTCTCTTGAACGTTCTTCTTCAAGCTGCCAATTCTCTATGTTATAATTTTCTTTAATGTATGCTATGTTCTCATAATCTTCTAAAACCTCCCTCATTAAAGTTAAAGATTTATAAGGCGGAATATCTATTTCAGCATATATTTCTATAAGTTCATCACTCATATTGGTACTTGAATCAGATATGCCTGCACATATACTTTTTACTTGTTTTTCACCTTTAAAAATTAACTGTCCTTTTTCTTTATCTAATGTCCATACCCTTTGAGTTCCTTTGCCGTCTTTATAATCTCTAAACTCATTTATAAATTGTTCTAAATCACCTGTTATAGTTTTTCCGCCTATTACTAATTGACTGTCGCTTTGTGCCTTTTCAATGAAAAATATATGAGGCTTTAATTTATTATTATCAAGCGGATCATTTCTATTAACAATATTTTCTATAGCATGCCTTGAAGTGTCGCATATTTCAAAAATTACCTCTGGTATTAAATCAGGGTTTAATATATCAGGAGTATAATATTTTATAGGCTTTAATTTTACTATAATACCATGCCCCGCTGCTAAAGTTCTGCATGTGTCAATATTATCTTCACCGCTGTCTACGTTCTCTGGGAAGTTTTTTAAATCAGGATATTCTTTTTCACTGAAAACATTTTTAGGAAGTTCAGTAGAGAAAGAAGCTCTCATATCTGATGCAGTAATAGTTACAGTCTCTAAAAAAGAATATTCAGGCTTTTGAATAAAACCTGAAAATATTATTTTTGAATCCTCAAAATTACTGCTGTCAAATATCTGCCTAACTAAAAATCTATTGCCATATAAATTAGCAAAATCATCAAATAGCCCATCATCATTTCTTAAAGTAACAGACATTTCATTTGTTTGAATAGTATCAAATGCAAGTGAATCTCCTTCTATATCTGCAGTATCTATTTCCTCAACTCTAGGCTCTATATACATATTATTTAATTCAGTAATTAAATCATTATTACTATCAAGCCATTCACGTGTAGAGAATAATTTTTTTATATTTATAATAATATTCTTTTTGCTATAAATAGTTTCAAAGTTATTAAAATGTATAGCTATATAACTAATATTATCTTTTTTATATTGATAGTAAGATTTATTTTGTTTATATAGAGCTTCTAAAGAAAATACTTCTACATATCCTCTATCATTATCAACACTTATAGAACCGATATTAAATAAATTATATAACTCACTTTCTTTAATATTAAATAATTCATTAAAATAAGAATTGCTGTATGATGAATATATTTCATTAATGCTGGCAATCCATACACCTCCAGAAGGTGCAAATATTAATTTAGTATCAGGGCTAGAAATATCAAGCTCTATAATATTGGCGAAACTTTTAAGCATTCATAAAACCTATTTTTGCATATACTCTATAACTGCTGAACCATTTTGACCATTATTCATTCTTGTTGGATTACCATCCATATATCCGCTAACTCCGCCAGCTCCTACAATAATTTTAATTTTAGAAGAAGTTCCTAACATACTTCTATTTATATCTACTATAGCAGCAGAGCCAGAACCTCCGCCTACAGAACCTTTGTTCCCAACATTATGAGATACCCCATTTCCTCCATTTCCTCCACTTGCTAAAGATTGATTATTTAAAACCCCACCTAGTCCAGGACTTCCTTTAGAACCAGCAGAACCATTATATAGTTTCCCTTGTCCGCTAGCCCTACCTGCTACTCCTGCACCTTGATTTAATCCTGTCATTATTCCGCCGCCGCCGCCGCCGCATGTTGTTATAGCACTATTATTTATTAATACTTGAGAATTGCCTCCATTAGTAGCATTATGGTATCCATTATTTCCAGTCTCTATTATACTCATACCAGCACCACCACCACCAGAACATATATGAACTGTAATACTATTAACATCGCTTGGGAAAGTAAACTCATGAGAACCAACTCCAAAGCTCACTGTTTTTCTTTTTAATATAAGTCCCTTTCTTTGAAAGTCATTAATATTCCAATATTGTTTTTCTATATATCCGCCTGAAGCACTACTATACTTCATACTAAGTCTTAAATATTTATCTAAACATCTGCCTTGTGAATCTAAATGATAAAAACCTCTATTATTGTAATCATAAGATGGAAAATTATTAGATACTACTTGAACTTCTAAATAATCATTATTGCTATTATTAGCATCTCTAACTATTGCTAATTTAATAAATCTTGAACCTTCTGATGATGAAGAATCTGATAGCTTAATTGTTTCATTAGTTTCAAAAAGTCTGCCCTCAAACTCACAGATACTTCCTGCTAAAATATCAGGCAGCTCCCTATCAGTATCACTCCAATGGTTTATTTTTATACCATCAAAAGCAGTATGAAGCATACGCATTTTTTGCATAATAATATTCTGCTGCCTATAGCTATTTAATAAATCGCTTGGATTTTCTTCAGCTTCTCTAATTACTCTAAACATCAGCTTACCTCATTATTATACATATTAAAATAATCTATTTGATAATATCCTGCTTTAGTTATAACTAATGGAATATATTTGCCTATCCCTTCATTACTAATCAAATAAAATCCGCCTAGCTCCTCATTATAATAGCAGTCTAAGCTATTAACTACTTGTGCTTCTAAGTTTTGCCCATTGTTAATTAATTTAAGCAGTATATATTTATTACTTTCACTATTAGTGTTATCATTTAATATAATATCTTCTTTAGCTTCATATAGGGAATAACAAAACATACATATAGAGCCTTTCTTAATAAATGGCATTTTGCTATTATTAGAAAAATCTATTTTTATTCCTTCAAAAGCAGTATGCAAAAATCTTATATGCTTTAATAAATAATTTTGTTTTTTATATGCCTCTTCAAGTGTAAGAGGTAGGCATGAAGGCTCATATATTAACTCAAACATATTATTTAATTTCCCTAAAACTCAATTCAGTAGAATACTGATATAAATCAGTCTTTCCTTTTTTGAAATCTATTTCTTTATTAGTACATACATAAAGACCAGACTTCATATAATATTTAGGATAAGTAACTTTTGTTCTATCTGCATACGATGCTTTTCCATATTTTCCAGTATTATATAGACTATTTATTTCATTAGGCATTATAGTTGGTTCAATCCATACTTGAAGCACAAAAGGTTCAAAATTATTAACTTCAAAAAAATTAATTATTTTTTCTCTATCAGCATTAGTTAAGTATGGAAAAGATACTTTCCAAGTATCATATTTTTTAACAGGAAGCCTTCTGCAAAAATAATGATTACTTGTAGAAAAAAATTGTTCATGAGTATAATTTACAGTATAGTTTTTTTGTTTATCATGCGGAGGAAAATCTACAGCTTCCCCTATAATAAGATATCCGCATTCAAGCATATTTCCGTCTGCTTTTTATTAAAAGTTATTTTTATTCTTGTAAAATCTACAGGAGCTATATTATAAACTCCAAAATTATTTTTTATATAAACAGTATAATTAATTATTTTACCATATATATTTTCTATTTCTACTGTCAAATATTCCACATTAGTATTAAATATAGCAAAAGAATTAATTATCCCTTTTCCATCTACAAATAAACTTGCTTTTTCATCAGTTTTGAATCTTCCTACTTCTAAAGTCTGATAGTTAAACATATTTGAAACAGGAAAAAAATCATCTTCTTCAGATTCCAATATACTAACTGGAAAAAGATTAAGTATATTATTATGTAATAACCTCATAATATACCTCTCTGACTAACAACTTTAACTCCACGTTTGCTTAAATTAAGCATTGTAGCTGCAACTATCTTACCATCAAGCATTAAGCAAATAGGCTGATTATATGAATCATCAGATGCATCTTTCACACTATAGCTTTGATCATTATTAGCAGTAGCCTCAAAAATGCTGCTTCCTATTTTAGATAGTATTTTATCTTCAAGAGGAATAACTGCTTCATCATTAGCACCCTCACCAATAACAGCATTAATTCCTCCCTGTCTTCTCTCTACAACTCCGCCTCTTGCCAAATATTTAGGCTCTTGAGGTTTAGCCTGACCAAGTTTTACTAAATTAATAGTGCCGCCTGCTATTACACCTAAAAGAGTAGCATAAGCTACTAAATTGGCAGGGAAAGGAACTGCCATCGCAGATGCTAAGGCATTAATTCCTGCTTGTGCCATTGAAGCTGTACCTTGTGCTAAAGACATTTTCCAGTTTTCTAATCTTGAATTATATTCAAGCCTCATTTTTTCATTATTGTAATTTTTTTCTATTTCTAACTGTTTTGCCTTTGCCTCTTCTTCTATTTGTATTTTAGACAGCTCTTTCTGTTTTTCCTCAAGCTCTGCTTTTATTCTTTCCTGTTCATAAAGTCCTAAGGCTACATTTTGTCTATTTTTAAGCTGTTTAATTTCATTTAATAAACTCTGCTTTTGAGAGTTTTCCATTATTCCTAAAGCTTCAAGCCTTGCTGCTTTCTCTTCTTCTATAGCTTTTAATGCTAATTCTTTACGCTCTTCAGTTTTATCTATTTCAAACTCTATAGCTTGTATTTTTAAATCTTGTACAGCAGTATATAGATCGCTCATATTATCTGCTACATCATTAAACATGTTGCTCCAGTTTGAAGCAAAATAAGAGCTAAAATCTAAAGTATTAACTTTCCATAAATCTCCAAACTTCTGCTTTAATATCTCTACTTGTTCATTTGTAAGCTTTATTTCGTTTGTTATACTTTCTATGCCGCTTCGAACTATTTCACTTTTAGCACCTTCTCTTTCAGCTTCGCTTATTTTTTCTCCAAACTCTTCTGCTACTTCAACATTTCTTTCATAAGCTGTTATGCTGTTTTCTATCTCTTTTACTAATTCATCAAATCTATCAGTCTTTATACTATCAAAAGCATAACCATAATTATGACTTAAATATTTTATCTGATTAGCATTCAAGTTTAATGCTGTACTCATTTCTGTAAGTATAGAACTTACTTTGTTTTTTTTAGCTTCTAAAGCATCAGCATCGCTTATTTCAGCACCTAAAGCATTAAGATTTTTTACTCTTCTAGTTTCATCTTCTTCAGCTTTTTTTAATTCTTTTAAATAATCTTCATAAGTTTTAGTATGTTCTTTTACAGTATCAGATTTCTTTTTTATGGCATCTATAGATTTTTGATTAGCCTTCTGCTCTTTAGTTTCTAAATCTATTCCGTCCCTTGTCAAGGACTGCCTTAATTGCATGTTCTGATTTAAGTCATTTCTTTGTTTTTCTAATTTTGCTAATGTATCTTCTACTTTCTTTAATTCGTTATAATCAGATGAATTACCAAGATCTAGTTCTCTTTGTATATAATTATCATCAGCACCTATAGCATATAAAGATTGTTTCCATCCTTCGAGGGCTTTTTGATAAATCTTTCTTTGCTTTTCTAATTCTTTAATTGTTGATTCTATAGTTTGTATATTAGTGGCTTCTTCTGCTGTTCTATAATCTTCAAGCTTCATAGTAGCAGAATCTATATATGTTATGCCGTCTAAAACTACTGTTTTTAAATTAGGATAAAGTCTAGTAAGCTTTTCAGTAACTTGATTTAATCTTTCTGTTGCCGCTGCATCAAGTTCTTTAGAACTTGCCAATTTTTGATACTCTTGGAATAAACCTAAATCTTTAAAAGCATTGTCATTTAATTCTTTTGTGCTGCTAGTAAGTTTTTGAGAGCTTTCTATTAATTGTTTATATTCTTGATTTAATTTATATGCTTTTAAAGCTAAAGCTCCAAGTCCTGCTGTTAAAGCAGTTACAACTCCAACAGGGCTTGCAAGTACAACTGTATTAAAACCTTTCCAAACAGTGCTTAATGCTTGGATAGAACTTACAGATGTTTTTAATGAGCCAATAGCACCTTTGAAATCATTAATTATTTTTTTAGTTTCTACAAAAGATTTTCTCAAACTTCCTATACCCTGCAAAGCGGGTCCCAAGCCAGCTGTAATTCCTATAATTCCAACCGTTGTCGCTTGCAAAGGAGCTGGAAGATTATTAAATGCTTTTATTAATGATGATATAGTTTTGATTGCATCATCAATTATTGGTACTAAAGTATCTCTAAATAATGGGATAAAGCTTTCGTTAATTAATGGAAGAGCATTATTGCCTAACTCTATAACTAAAGCACTGAGTTCTGCTTTAAGTCTTTCAAATTGTCTTGCCGCACCATCATCTATTTTTTTGAATGCTTCAGAAGTAGCTCCAACGCTATTTCTCACTTGATCCAAATAGTCTTTGAACTTACTTGCATTTTTACCAGATAAAGCTAAAACAGCGTTGCCAGCATCTACGCTAGTAAACATACTTGTAACTTCTTTTCCTGTTTTTTCAGCATAATCGCTCATCATTTGAAGAGCTTCTTGAAGGTTGCCTCCTCCTGCTATAAAGTCTTTGAAGCTTTCACCTGATATCTGTTTAAATGCTTCGTAAGTAACTGAACCCTCTTTATTAAGATCAGATAAAGCCTGTTTCATTTGTGTCGTTGCAACAGATGTAGGAACACCCTGAGCAGTCATTGCCGCAATAGCAGCTCCTATATCCTCAAACTGAACACCTATAGCAGAAGCTATTGGAATAACATTATATAAATTATTTGATAATTGTGTAAAATCAGTTTTACCTAATTTTACTGTTTGAAACATTATATCAGAGGCTTTTTGAGCATTTAATATTTCTGAGCCATAAGCATTAGTAACACTTGTTAATCCATCAACTGAAGTTCTTAAATCACTAACTCCAGCAATAGAAGCCTCTCCTGCTGTTTTTAAGAACTCAAATACATTTTCACGTGGTATGCCTGCAGATAAAGCTTGATAGAGTGCTTTTACTGTTTCTTCTGGTGCTTTACCTATATCCTTTGAAAAAGATAAAGCTTGATTCTTTAATTTCTCAAAACTTTCATTGCCTAACTCTGGAAGCAAAGTAAGAACTTCACGCATTCCATTATCAAACTCTATTGCTTTTTTAGAAGCGAGTCCCATTGCTGTGGTACTAGCAACTATTGGGACGGTTAAACTTTTGGTAGCTAAAGAACCAAAATTAGAAAAAGCCTTTCCTATTTTATTAAAACCTTTTTCTAAATCAGTAGTTCTGTCTTTAAGTTTGCCGAATGCTTCAATGGCTTGTGATGCATCAGCATATATACTAACATTTAAACTACTCATTAATCTTTAACTCCAATAGTTCCGCTATTTATTATCAATTGTAATGGTTTCTACTTCCCAAAGTCCTTGCTTTTCTCTTTTTATTTTCTTATTGCCTTGTTGAGTTTCAGTAATATTACTATCATTATATGTTTCATATTCTATTGTATATGGCAGCTGAAATGATGCAGTATAATAGAGCATAAGTCTTGAAAGACTCATGCTCAGCATATACTCTTCTGTCCAACCGAAACAGTTGGCTAAATGGGCAAGTAACTTAATTAATTCTACTTTTAACCTTTTTTTTATTATCTTCTTTTTTAGGTTCAGTTCCTGCTGAGAAAAAGCAATCAAATATCATATTCATTACTTTCATTATTTGATCATAACTAAACTTATTTAAAATATCTTCCTTTGTAAGATCTTCATTAGTTCGCTTTATTACAGGTATTACGACTTCATCTATTAGAAGTCCTATGTCTACTGATTCTCCAGTTCTTATATTATTATGATATTCGTTAACTTTTAATGCCACTTGTACAGGCACATCATTAACATTAATCTTATAATCACCTAATTTAGCATAAACTGCTTTTTTCTTTGTAAACTCTTCTAAATCTACAATAGTTACTTCCATTATTCTATTATCCCCCTAATTATTTTATTCTTGTATATTAATAACTATATCTAAAGTTTTATCTTCAGAGCCTGCTTTTTTAGCTGTTATTTTTAGTGTAGCTTGTCCTGGAGTTTTTCCTGTGATAGTGAAAGTTTTAGTTTCCTCTTCATAGCTTATATCACAAAAACCTTGTTCTGAAGGCTCTACTGCATATTTTATCTCATCAGCATTTGAAGTTAATACAACTGTATCACTTCCAGTGCCTGATATATCTACATTTTGTTTATTGCTTTCTAAAGTAAGAGGCTCTATTATTGTTTCATTTTCATCATTGCTTACAGATTGTTCATCTTCATACCAAGCCAACTGTTCGCCGCTTTCCTGACTTCCTGATGTACTTGCTGAGAAACTTAATTTTCCAACTAGTACATCTTGCGATTTGTCAGCAGGGAAACTAAACTCTAAACCACCTGTTATAGCAGCCTGAGGTAAATATACTCTTAATTCTTTACCTTCTGCATTTGTATTAACTAACATTATGCATTTAGGTTTAACAATAGAGCTTTTTCCGCCTGTAGTCATACGAACCATCTTAGGCATTATTCTTTTATATGTAATAACTAAAGTATCTGTGCTTGGAGATATATTATTATCTGTAATTTTTATTCCATTAGTTCCTATTTTCTCATAGCTTGTTTCTTCTATTAAAACATTTCCTGTAGAGCTTTTCTTTTCTACTTTTGTGATGGTAACATCACTTCCATCTGCGTTCTTAAATGGAACTTTTATCTCTTCGCCTCTTTTATATGTATCTGATCCAACTATATATGCTTTTGTTATTTCTGTTTTTCCATCATAAGTATCTATATTATCTATGCCGCCTCTTGTCATAGCATATTTCTCAAAGTTTATTTCTAAACTATCAAGAGTTACTTCCATTTTATGTTCTGTAGTTAATGTATTTACAACGCCTGCATTATCACTTTCTATATCTGCTGTGGTAATAGTTTCTTTAAGGGCAATACTTCTTGCAGCTCCTATGTCTACAAGTTTATCAAACCTATCTCCTATTAGAAGTTTGGCACTTCCAGTTCTTATTGTTCTTTTATTTTGTACATATGTTTGACTCATGATGTCTCCTTTTAATATTTATATAATATATTTATTATGCTGATAGCTTGATAAAAGCCTTCGACATAGCTATGTGTCTCATTTGAAACATCACATCCGCATATTTCTGTATCTTCAATAATATCTATTAAATTGCTAAAATGTTTCCCTATATCTCTTTGAATATTTAATGCTTTACTAAGATCATTAGAATATACAGCTATTTGATAAACATTCCTGCCATATTCAAAATTATAATGCGGTGTGCTGCTTATTAAAGAATAAACTATATATGTCTTATTTTTATCTATTGTTGAATCATTAACAAAATCTAAATAAACACCATCTGCTTTATCTTCTGTTAATTCTTTAAGTATTGTATATATGGCATTTTCAATCATTTCTTTTTATTTGCCTTGTCTATTGCTTTTTGTAAGCTTTCTTTTATATATTGTTCTATAACAGGTTTCTTCTTTTCAAAAGTAGGAATTAAAAGAGGCTGCGGTGCTTGAGTAGCTGTACCAAACTCTGGGAAACGAACATAATATCTATCTCCCTTCTTTTTATACCATATTATTTTATTTTTTGATGGAGCACCTGTGCCGCTAACTTCTAAAGTACCAACTTTTATTGCAACTGAGGTATCGCTTCCTTTTGATGACTTTTTTTCTTTTACATCATAGTATTTATCTTCAGTCCAACCTCTGCTTTTAGCTTCTGCATTAGCTTCTTTTGCTATTTCATTTCCTGCTTTTCTAGCACCTGCTTTTATTGCTTTTTTGAAATCGCCGCCTAATTCTTCTAAAGTTTTTCTAAACTCATCAAGTCCTTGTATACTTATAGAAGTTTTTCTGCTTACGCCTGACATATTATCCGCTTTTATTATTTACTAATTTCTTTATTGTAAAAATACACTCTATATTTTTATATGAAACATTTTCTCTATAAATGACTTCATAAATGTCATCTTCATGATTTATTTTGGCCATCATTCCTTTGGTATCAAACTCTTTGAAATAATGTGTATGCACCTTCAATGTACTTTCTAAATCTTTTCTTTTTCCCTGCTCTATATCTTTGTATGTTATATCTTCAATAGAACATTTAACTTTTTTAAGCTCTACTAATTCATTATTTCCTGTTCCGTTTCCATTATCTATATATGTGCTAGTATAAAAAGTGATAGTATGAATTAATTTCCCTACTTTCATAAGGTTATATTTTCCCTTGCTATAGTTAACAGCCTATGAACTCCTTTCAAAGCTACGTCTTCACTTTGACTTGCTTCTCCTGTTTTAGTTTCAAAATAATGAGCAGCAAGCCCAAGTATTGCATATCGAACTTCAGGAGGACAATCAATTCTTTTGTATTCAGTTTCATTAGCTTTATTACAATAGCTGATTGCACTGTCTAAAGTTAATTGCAATATATCATCATCATAATCAATGCCTTCTAAGTTTAGAAACTTTTTGAACTCTGACAAAGTAACAACTCTGTCATCATCTCCGCTTTCCACAACACTAGAGACATCAATATCTATATTTTCATTAATATCCTCAGGTTTGCTACTCATTTTTATATCCTAAAACTAATTATTTATTAACCAGCTGACTCAGCAACTGATTTTGCAAATGGTTTATCATGTGCTACCAATCTTACAAAAGCCTCTTTTTGAACAGGAGCACCATCTCCATAGTATCCTACTTGGAATCCAACTTGATTTGTTGCACTATATAATTCATATAAAACTTGAAGTTCCATAGATAAGCTGTCCATTATCCAATAATGAGATAAATTAGCTAAGAATCCAAAATATTTTGTAGATTCTAATTTATCCTCAATAAAGTCATTTTGCACAACAGGTATTCCTAAAAGCATACTAGGCTGTCCTGCTTGTAAACTTTCATTCCAAATAGGACGGTCTTGTTTATCTTTTAGTTTTCTTAATGCCGCAACTGCTTTTTTATTAAGCATCCATACAGCTCCATGTTGATATCCGCTTTTTAAACCGCTTACAGCATCTACTAATCCATCATAGGTTATAGCAGCTGTTGTAGTTCCAACAGCTATATCTCTATCAGTTGGAATACTAGAACTGTTGTCTGAAGTCTGAGCGAAAATACCAAGAGGTTTTCCTGTACCATTTCCATATAAATAATTATGTTCTAAAGTAGAAGATAGCTTGTATGCTATTCTTTCTTGAACTAATTTTTGAACATCTATATTGCTGTCTCTAATTAATTTTCTACTTACCTTAACTAATTTAGTTAATTGATTAGCTTTCATTTCTCTTTTACCAAAAGACATATTTTTATCTTCTGTAACTTCGCCTATTTCTGGTGTCCAGTCTAAATCATCAAAATCATTTTCAAGTGTAGGTATTCCTATGCTTGCATAACCATTCATAGCAGGAATTACATATGCTCTTTTTCTTACTTCTACAGATAAATCCAATCCTTTTATTATATCTTTTACAAGATATTGAGGTGCTATAGTATTGCCGCCTGCTTCTGCCACTCCTGCCTGAAGTTCTTCTCTTACTTCTTTATCATCTCCTGTTCTTAACCATCTAGTAACTTTATCTCTTAATTCTGTGTCATTGTTAGCAGTAGAAGAGTCTAAATCATCAACTATATTTCTTTTATTCATAGAAGATTTAGTTTGAAGTGATAAAAGTTTATCATTTCTTTCTATCTCCTTATTTCTATTTTCTATATTTTGCATTAAAGTATCTATATCATTATCTAGCTTTGATATATCTTCTTTCTTGTTTGCTCTCTCCTCTAAGCTCATAGCAGAATATAAATCTCTTTGAGAGATAAGGTCTTCAACTTTTGTTAAGTCTGAAGCATTTTCTGATTTCAAGTTTGCTATTTTAGTTCTTAAATCTTCTGGTGTCATAAAAGCTCCTTAATTATTTTTGATTTTTAATAGATTTATTTTTTGGTTATATGTTATAGTTCTATCTTCAAAGCCATCATCAGTAATTTTTATTGGCGGCTTTGGAACATATATATCATTTTTATCTCTAACATTTGTTTGAGGGTAGGCTGGAAATGTAACTAATGATATTTCATGCAAAACAATTTCTTTCACTTCACGAATTGGCATTCCATATTCTTTTATTATGTCTTCATCATCAATCCATTCATCGTCTTTTACTTTGAAGCCAAAAGACATTTGCTTTATATCGCCTCTGTTTACGCTTTCTTTTAAATCTCTTGCCCAAGTAGTATTTGGAAGTTCTACTTCAAAATATAAGCCTTTTTCATCTTCTCTTAAAAACAATGTACCAGCACTTTTTCTGCCTAAAACATATCTTGTATCATGCCCCCACAAGCATACTTGATCATCTTGTGCTAAAGACTTAGTAAAAGCACCACTTTTTATACGCTCTCTAAATAAATCACCATAAAGAGGCTCACTTAAAGCATTATAGACTATAGCATAACCTCTTAATTTAAGAGGTTCATCTTCTGTGTTGTTTTCAAACCTAATGTCTATATTTCTAATTTCACTATTGTTTGCTGGCAT

Protein sequences of DBSCAN-SWA_1

>NC_018607|1994918:2029773|1999839_2001030_-|WP_014936409.1|DBSCAN-SWA
MNRRNQFFDKIIKNFDKVSDIEKKRIIERLALLSNSQNIIIENLEEGIIAIDINGIIQGINKKACFLLSIPRNSEDKAISKCINNTNIGRLILELLEANNTDTKIIKDDKNDRMLQIDILPLGDSGIIIGTLIKIFDITKSYESAQKLKRAEQLASFTTLAAGVAHEIKNPLGSISIYVQLIEKIIKKNIDNDCQCYNEFRDYCNIIKEEISRLEDTINSFLFSVRKLVLNLEDININSLILSTVDFLKYEIENNNIKIDIKFDIENLILKIDEKYIKQCLINIIQNSIDSIIEKKKHNKSDENNISIKLKLLDNYALISIKDTGIGIKEEELSKIFEPYFTTKRNGTGLGLTNVIRIIEAHNGSFNIESKYGFGSEAIIKLPLMLENQKFLESDF
>NC_018607|1994918:2029773|2027446_2027812_-|WP_014936434.1|head,tail|DBSCAN-SWA
MSSKPEDINENIDIDVSSVVESGDDDRVVTLSEFKKFLNLEGIDYDDDILQLTLDSAISYCNKANETEYKRIDCPPEVRYAILGLAAHYFETKTGEASQSEDVALKGVHRLLTIARENITL
>NC_018607|1994918:2029773|2027838_2029140_-|WP_014936435.1|capsid|DBSCAN-SWA
MTPEDLRTKIANLKSENASDLTKVEDLISQRDLYSAMSLEERANKKEDISKLDNDIDTLMQNIENRNKEIERNDKLLSLQTKSSMNKRNIVDDLDSSTANNDTELRDKVTRWLRTGDDKEVREELQAGVAEAGGNTIAPQYLVKDIIKGLDLSVEVRKRAYVIPAMNGYASIGIPTLENDFDDLDWTPEIGEVTEDKNMSFGKREMKANQLTKLVKVSRKLIRDSNIDVQKLVQERIAYKLSSTLEHNYLYGNGTGKPLGIFAQTSDNSSSIPTDRDIAVGTTTAAITYDGLVDAVSGLKSGYQHGAVWMLNKKAVAALRKLKDKQDRPIWNESLQAGQPSMLLGIPVVQNDFIEDKLESTKYFGFLANLSHYWIMDSLSMELQVLYELYSATNQVGFQVGYYGDGAPVQKEAFVRLVAHDKPFAKSVAESAG
>NC_018607|1994918:2029773|2016754_2018695_-|WP_014936423.1|DBSCAN-SWA
MLKSFANIIELDISSPDTKLIFAPSGGVWIASINEIYSSYSNSYFNELFNIKESELYNLFNIGSISVDNDRGYVEVFSLEALYKQNKSYYQYKKDNISYIAIHFNNFETIYSKKNIIINIKKLFSTREWLDSNNDLITELNNMYIEPRVEEIDTADIEGDSLAFDTIQTNEMSVTLRNDDGLFDDFANLYGNRFLVRQIFDSSNFEDSKIIFSGFIQKPEYSFLETVTITASDMRASFSTELPKNVFSEKEYPDLKNFPENVDSGEDNIDTCRTLAAGHGIIVKLKPIKYYTPDILNPDLIPEVIFEICDTSRHAIENIVNRNDPLDNNKLKPHIFFIEKAQSDSQLVIGGKTITGDLEQFINEFRDYKDGKGTQRVWTLDKEKGQLIFKGEKQVKSICAGISDSSTNMSDELIEIYAEIDIPPYKSLTLMREVLEDYENIAYIKENYNIENWQLEEERSREIAVLLDNDNKKTTLDLIGELSFLEQGRLEVYDNKIDFISTRFRENKAKYKLKQYCMGRIDKTVESDEYLSSCSIKYDLLKSTYKNTEFEEEAKKRHRINAHEEFETLLKLKEDAISLSNEIMKSRYLLKEYYTFEYYETLDFLKLFDIVEIEYERENGSYYIKPCLCEIIKLNIFDNVIKLRQI
>NC_018607|1994918:2029773|2015153_2015747_-|WP_014936419.1|DBSCAN-SWA
MLNENILEKIGINKKWLDPLNNAFNKYNITDTKEAAMFLAQTTHESNNYKRLEESFKYTPPRLYDVFRKRVGSLENAKQLCLQGAEAIANFVYGGRLGNAEDEGYKYRGRGIIQLTGKSNYKKYGKKINVDLVNNPDLAKKTNNAIEIALLFWQERGCSLLACQGDVKGVTKLINGGYNGLEDREERYKKILKILEG
>NC_018607|1994918:2029773|1997611_1998076_+|WP_013244842.1|DBSCAN-SWA
MGLFSKKIQIKAPINGKLIDITEVKDEAFSSKALGDGMAIIPSEGKVYAPVDGEVITMIDTNHAIGLLAGGVEILIHIGMDTVRLGGKYFKAHVKEGDKVKAGTLLIEFEKEEVEKEYDITSPIIISNYSELKSLTKTDPREVNTTEIIMTAVK
>NC_018607|1994918:2029773|2012296_2014126_-|WP_014936417.1|DBSCAN-SWA
MSLEKLEKPDNYKEVPALQDGETVYAQDHNQIIANIEKIKGGKPNEAPVSNIKELKDILDGILNKKALTASHISFDNEEAKLTYKKYNFPKFKTNIETINLVLTDEERTNEYTAVIEKEGNDYRIKAIISNCHVNKIVRLIIKSVNGQEELELKYNVLSQFFNINNMIYRLAPNECQISNIDSTLVFNISIQSTELLLTIAKAEFPTEIAEGNYNIVLDIKNKQLNKLDTNIYFLLIGSLTPFKLEIVKKDDNQIRFKGHYICKSSLIHPTCYSPILENYFNIIDSNDNLINTDGIISSSGKPKKFGFMRYKNKANTYYLKIVNQDGSELEADEIIMFDLIPDKNAEVEVKEKVIETVQDAIEALNKDIDLDYFEAKPQPEPQEEVSNFEIVSYFLNSPMVDNKVEDCSKLSLVKNADNSYSLKGNIKLYEDTNRSSCMIIKTTNTINTIGGNIKNIIPAIITDNLYVVSLAHENYIYLNMQKINENPVIEESFDNIKLIDTNIVLFNNKVVNEISVSKVSDDFGIVYEDGNYKIKGQLTFSNEETNFTAITNNGISDFFENNEEYSINTNEGTLKAIYHRNNNIMCVLEFQGNAGTTYNIDWVLPKQI
>NC_018607|1994918:2029773|2024555_2024741_-|WP_041747756.1|DBSCAN-SWA
MLSMSLSRLMLYYTASFQLPYTIEYETYNDSNITETQQGNKKIKREKQGLWEVETITIDNK
>NC_018607|1994918:2029773|2016539_2016737_-|WP_014936422.1|DBSCAN-SWA
MTSLGVLAISEMDTDDIAYRIDCYNCIELKADIERVAEKLNIKKPFSVRDAIEIANYMNMEDNRL
>NC_018607|1994918:2029773|2016147_2016543_-|WP_014936421.1|DBSCAN-SWA
MKDISCNICDKREKCTKLCPSMIEHLQTISGKKLSYLDMTSYNSDKNIDDVEDLSLYTYGLSKVQERDVKRIIIAILPKDHIEVLKLYSNGYTQKEIGEKLNVSQSSISQKLEHIKKSLKDSIVAVLSYLV
>NC_018607|1994918:2029773|2025171_2026260_-|WP_014936430.1|DBSCAN-SWA
MSQTYVQNKRTIRTGSAKLLIGDRFDKLVDIGAARSIALKETITTADIESDNAGVVNTLTTEHKMEVTLDSLEINFEKYAMTRGGIDNIDTYDGKTEITKAYIVGSDTYKRGEEIKVPFKNADGSDVTITKVEKKSSTGNVLIEETSYEKIGTNGIKITDNNISPSTDTLVITYKRIMPKMVRMTTGGKSSIVKPKCIMLVNTNAEGKELRVYLPQAAITGGLEFSFPADKSQDVLVGKLSFSASTSGSQESGEQLAWYEDEQSVSNDENETIIEPLTLESNKQNVDISGTGSDTVVLTSNADEIKYAVEPSEQGFCDISYEEETKTFTITGKTPGQATLKITAKKAGSEDKTLDIVINIQE
>NC_018607|1994918:2029773|2011826_2012051_-|WP_014936416.1|DBSCAN-SWA
MLNCFKDLISSSKTGHLSSMRLISLLGSTVMLVCVSFLVFSKDERLIESLPFFIGGLLGLAGFKSYQAKFEGDK
>NC_018607|1994918:2029773|2001182_2001716_+|WP_013244839.1|DBSCAN-SWA
MIRKLVIYGDDRLKEKSSYVENVDEEILTLIDDMFETMYKANGVGLAAVQVGVLKRVIVISVPDFDDETKPDFKLALINPEIIWHGEDTEILEEGCLSFPKISDEVARYKEIKVKYIDTENKEQILDAKDYIAKVLQHEIDHTNGITFIDRLESYQKRRLKKDLKELRNTHKKTVSA
>NC_018607|1994918:2029773|2004829_2005849_-|WP_013244834.1|DBSCAN-SWA
MRNFTLLLILLFQFSLYPEITLSFVGDVMTGSDHPDKSYLPPNEGKDVFKSVSSFLKASDISFANLEGAIANSETKSAKTGKRSYSFRMPPYMADRISEAGFDIVAVANNHSRDFGAKGYSQTQEYVKKAGMEVVGNVLNQASFIEVKGKKIGFLAFYYFSYANNSIQDIAAAKALVEKTKKECDFLVVSFHGGAEGSSMFRVPKTTEYFYKENRGDVYKFARAVSDAGADLVVGHGPHVLRAMEMYNNTFIAYSLGNFVGYKQFSLSGNNGISAILQITLDDDLKVSKAKVIPVRLVNGGIPSVDSANTAIKKLNEYADLDFQKTGVKFNDDGEYLVK
>NC_018607|1994918:2029773|1996462_1997530_+|WP_013244843.1|DBSCAN-SWA
MILKELTLRSFRNYNENTFEFSKHINILYGINGCGKTNILEAIYILGNGISFRTRLDRELIKYGNDNYFLRGIFKEDDLNYDTNIEIVYQKKTKKVFINKKEITSRKNLIGKILYVIFLPNDTDMVTSEPKLRRDYFNMLISSISNEYLLSLIKYNKLLKMRNIYLTTSPNDAHIYNEDIAKLSLYIANENKKYSMLLEEKMNEIYRTIFKNDNPYKIKYLSTIEDIANENEYIKKLESTIKEQIKMRTTYFGIHRAEYQFFYKDSLSRKFSSQGEKRMLTLIMKLASEKILYEYRKKSPILLIDDAMLELDNIKRESILEYIKTLGQVFITVTEKEKLSKFEESKVFDIVNIKN
>NC_018607|1994918:2029773|2026271_2026640_-|WP_014936431.1|DBSCAN-SWA
MIENAIYTILKELTEDKADGVYLDFVNDSTIDKNKTYIVYSLISSTPHYNFEYGRNVYQIAVYSNDLSKALNIQRDIGKHFSNLIDIIEDTEICGCDVSNETHSYVEGFYQAISIINILYKY
>NC_018607|1994918:2029773|2001724_2002405_+|WP_014936410.1|DBSCAN-SWA
MIKNIIFDLDGTLIDSIPDINASVNKTLEHIKFPSLDIEYTKKYVGNGARLLINRVLNHFADKYDKEYLESIENDVYNFYIDYYSKHSTDNTKLYDNVLETLTSLYKLNINMFIISNKPNEITITTAKKLNIFNYFKAVIGDGIYPYRKPDVNIWYNLKRDYILIEEETIMVGDGVPDYEFAKNAKIKALIALYGITDKQTLLNLKNDCYINSFKEVEDFVLSSNK
>NC_018607|1994918:2029773|1996103_1996391_+|WP_013244844.1|DBSCAN-SWA
MIKIVAKNYIKKDKKDDFLKLAKELIIESRKEDGCIAYDIYESIDGLCLTFIEEWKDEEAIKSHNSSNHFITIVPKLAEFLDGEMDVTLYKKINI
>NC_018607|1994918:2029773|2008211_2009375_-|WP_014936413.1|integrase|DBSCAN-SWA
MKTIECLKLYDNNNSNLIIQYLEYSKLYKSKATIQIYSSCIKRFYDFLFFYYDNRQSENTQSYYTTVLYNKVDRKCIEDYIAYQVNKKVSADFIHCMIMAVKNYFKYLLKLKKISTETFFDIFDELKTPKIIVKKQLLIKADKTLSITKAIAEKSKSPNLFFLDQRNIFMLLLMSNTGIRRKELACIDITNINMNNNTITIYKTKGDKPRIISFSDSIKSKLIEYLKLREERLSRKNKKHNMLFIKKNSEPLNINTISTIMDIISKKTNIKVTCHSLRRGFATDMAESGTDIYVISKMLGHQNINTTVSRYIYVMASMIKEAMQNHPFAKNREKQNSTKQDCTNSDKNIKSAEAESIKNMLDEWKDLSQKMNEIINHLPRETDLKKA
>NC_018607|1994918:2029773|2024787_2025147_-|WP_014936429.1|DBSCAN-SWA
MEVTIVDLEEFTKKKAVYAKLGDYKINVNDVPVQVALKVNEYHNNIRTGESVDIGLLIDEVVIPVIKRTNEDLTKEDILNKFSYDQIMKVMNMIFDCFFSAGTEPKKEDNKKKVKSRIN
>NC_018607|1994918:2029773|2021057_2024531_-|WP_014936428.1|tail|DBSCAN-SWA
MSSLNVSIYADASQAIEAFGKLKDRTTDLEKGFNKIGKAFSNFGSLATKSLTVPIVASTTAMGLASKKAIEFDNGMREVLTLLPELGNESFEKLKNQALSFSKDIGKAPEETVKALYQALSAGIPRENVFEFLKTAGEASIAGVSDLRTSVDGLTSVTNAYGSEILNAQKASDIMFQTVKLGKTDFTQLSNNLYNVIPIASAIGVQFEDIGAAIAAMTAQGVPTSVATTQMKQALSDLNKEGSVTYEAFKQISGESFKDFIAGGGNLQEALQMMSDYAEKTGKEVTSMFTSVDAGNAVLALSGKNASKFKDYLDQVRNSVGATSEAFKKIDDGAARQFERLKAELSALVIELGNNALPLINESFIPLFRDTLVPIIDDAIKTISSLIKAFNNLPAPLQATTVGIIGITAGLGPALQGIGSLRKSFVETKKIINDFKGAIGSLKTSVSSIQALSTVWKGFNTVVLASPVGVVTALTAGLGALALKAYKLNQEYKQLIESSQKLTSSTKELNDNAFKDLGLFQEYQKLASSKELDAAATERLNQVTEKLTRLYPNLKTVVLDGITYIDSATMKLEDYRTAEEATNIQTIESTIKELEKQRKIYQKALEGWKQSLYAIGADDNYIQRELDLGNSSDYNELKKVEDTLAKLEKQRNDLNQNMQLRQSLTRDGIDLETKEQKANQKSIDAIKKKSDTVKEHTKTYEDYLKELKKAEEDETRRVKNLNALGAEISDADALEAKKNKVSSILTEMSTALNLNANQIKYLSHNYGYAFDSIKTDRFDELVKEIENSITAYERNVEVAEEFGEKISEAEREGAKSEIVRSGIESITNEIKLTNEQVEILKQKFGDLWKVNTLDFSSYFASNWSNMFNDVADNMSDLYTAVQDLKIQAIEFEIDKTEERKELALKAIEEEKAARLEALGIMENSQKQSLLNEIKQLKNRQNVALGLYEQERIKAELEEKQKELSKIQIEEEAKAKQLEIEKNYNNEKMRLEYNSRLENWKMSLAQGTASMAQAGINALASAMAVPFPANLVAYATLLGVIAGGTINLVKLGQAKPQEPKYLARGGVVERRQGGINAVIGEGANDEAVIPLEDKILSKIGSSIFEATANNDQSYSVKDASDDSYNQPICLMLDGKIVAATMLNLSKRGVKVVSQRGIL
>NC_018607|1994918:2029773|2009500_2010475_-|WP_014936414.1|DBSCAN-SWA
MKKILLILFILSFNLLAQNYNLLKSRDKESLVILEKIIKNNTDVNTIITNSVINQAYTPLIYAIMISNTEIVKELIKRGADVNKAVTNTIRYKGINGESIYNIVTVPIVLASSLTNLNILKELINNNADINIEGGRTLLFYAQDKYIAAELIKLGIDVNAKDTNGKTALFTVGYDAVEKLVSSGAQLEVRDNEGNTPLLCFINSYNIDYKKLEILVKIGANINAKDNNDDTLLINAIYRGNIELIKKLLELGADIEIRDKNGNTPLMIAIWQYYSSSNEKDLNIIIELVNYGADIYAKHQYGITPYKTAEDIESKEILNIFNDR
>NC_018607|1994918:2029773|1995514_1996111_+|WP_013244845.1|tRNA|DBSCAN-SWA
MTKLVIGLGNPGEEYKNHRHNIGFIIIDKLAQNLSLKFDNNKKKSLFTRAKLNNTDFILLKPQTFMNLSGESAIYISKFFNIKPEDIIVIYDDMDIPFGTFKIKKGGSSGGHNGIKSLIAQLQTDDFIRLRVGIGRPSFGKKVNDYVLSSFSKSERENIDNDLGENVIEAIKTILFESYTIAQNKYNKRINNKDTNND
>NC_018607|1994918:2029773|2029149_2029773_-|WP_014936436.1|head,protease|DBSCAN-SWA
MPANNSEIRNIDIRFENNTEDEPLKLRGYAIVYNALSEPLYGDLFRERIKSGAFTKSLAQDDQVCLWGHDTRYVLGRKSAGTLFLREDEKGLYFEVELPNTTWARDLKESVNRGDIKQMSFGFKVKDDEWIDDEDIIKEYGMPIREVKEIVLHEISLVTFPAYPQTNVRDKNDIYVPKPPIKITDDGFEDRTITYNQKINLLKIKNN
>NC_018607|1994918:2029773|2026636_2027107_-|WP_014936432.1|DBSCAN-SWA
MSGVSRKTSISIQGLDEFRKTLEELGGDFKKAIKAGARKAGNEIAKEANAEAKSRGWTEDKYYDVKEKKSSKGSDTSVAIKVGTLEVSGTGAPSKNKIIWYKKKGDRYYVRFPEFGTATQAPQPLLIPTFEKKKPVIEQYIKESLQKAIDKANKKK
>NC_018607|1994918:2029773|2014724_2015150_-|WP_013244393.1|DBSCAN-SWA
MSPKKTTQTASQENTISTLEKRLMHVEHTVGINEDGTKNGNGLIHKIEEVKEQIKNLSDDIKSYDTYLDNLSEDIIKIDFRLERLETQIKDFLDELKEIKKSLEGNININTLSNIRKAIVGIAAVLTGLGTIIGFIIHFAK
>NC_018607|1994918:2029773|2002923_2004534_-|WP_014936411.1|DBSCAN-SWA
MKIKLLLFISSLFLFASCGGGNKFEEGVLRLNVGPEPQSIDPTLNSAIDGSMYIIHAFEGLAQKDKEGKIVGGVAESWDISENGTKYVFHIRSNAKWSDGKPVVADDFVYSWRRAADPKTAANYSYQMEPLKNAKKITAGEMPVESLGVKSIDDNTLEVTLEAPTPYFDQLMAYPVYFPLRKDIIEANPDTWTMSADTYIGNGPFKMTEREIDSKIVMEVNTNYWNRSIIVPKKLIFILMDNPTSVVAGIKDGSIYFSDRVPTQDMDTLKEEGYLKIEPYLGLYYYSLNITNETLKDKRVRRALALAIDRNYIVSQVTRGGQTPAAAVVPPQISDVTGKFRENGQDSFSLKAEDYQKNIEEAKKLLAEAGYPNGENFPVLEFKTNPGEHTSIFEAIQQMWKNNLGIDTTIVSEEWAVFQSSRYSRTYVIARNGWIGDYDDPMTFLGMFLSYSPQNVESYNSAIYDRLLANASATDDNTIRMPLLHKAEELFMEDMPIIPLYYYTLPLLVNNNLKDVQYDVLGKHKFFYAYYDNTEK
>NC_018607|1994918:2029773|2018704_2019790_-|WP_014936424.1|DBSCAN-SWA
MFRVIREAEENPSDLLNSYRQQNIIMQKMRMLHTAFDGIKINHWSDTDRELPDILAGSICEFEGRLFETNETIKLSDSSSSEGSRFIKLAIVRDANNSNNDYLEVQVVSNNFPSYDYNNRGFYHLDSQGRCLDKYLRLSMKYSSASGGYIEKQYWNINDFQRKGLILKRKTVSFGVGSHEFTFPSDVNSITVHICSGGGGAGMSIIETGNNGYHNATNGGNSQVLINNSAITTCGGGGGGIMTGLNQGAGVAGRASGQGKLYNGSAGSKGSPGLGGVLNNQSLASGGNGGNGVSHNVGNKGSVGGGSGSAAIVDINRSMLGTSSKIKIIVGAGGVSGYMDGNPTRMNNGQNGSAVIEYMQK
>NC_018607|1994918:2029773|2027108_2027450_-|WP_014936433.1|head,tail|DBSCAN-SWA
MKVGKLIHTITFYTSTYIDNGNGTGNNELVELKKVKCSIEDITYKDIEQGKRKDLESTLKVHTHYFKEFDTKGMMAKINHEDDIYEVIYRENVSYKNIECIFTIKKLVNNKSG
>NC_018607|1994918:2029773|2019789_2020242_-|WP_014936425.1|DBSCAN-SWA
MFELIYEPSCLPLTLEEAYKKQNYLLKHIRFLHTAFEGIKIDFSNNSKMPFIKKGSICMFCYSLYEAKEDIILNDNTNSESNKYILLKLINNGQNLEAQVVNSLDCYYNEELGGFYLISNEGIGKYIPLVITKAGYYQIDYFNMYNNEVS
>NC_018607|1994918:2029773|2014163_2014700_-|WP_014936418.1|DBSCAN-SWA
MPIITAFLSKIDKRIFIAIGIVLFVAIFIILMAVKDSEIRQKEKEIAEYQENINGLELKTQTLQSEIQFIQENQKLQNSFSNSDAMIKNIDKESLTRTEHETFNSISNNFYNYFNNITFLSSTSKICKNTALYSSRNIHYKTSYKQTGFNEKISREYYKNRRVANMVQRPSWNKLFLL
>NC_018607|1994918:2029773|1994918_1995518_+|WP_014936408.1|tRNA|DBSCAN-SWA
MMKLVMGLGNPGSEYQNHRHNVGYMILDKVAKKLNVELDIKKKKTVFGRAKYGKIEYLLLKPQTFMNLSGEAALYMASFMKIAVDDIIVIYDDMNIPVGEFKLVIAKNDANDNDNEEKEGPIKHNGIKSIEESLKSNNFTRVGIGIGTPAEGQEIADFVLSPFTKDERKKIKDITDDVVDAICKVLFESNNKTSKKKYL
>NC_018607|1994918:2029773|2006054_2007233_+|WP_014936412.1|DBSCAN-SWA
MRKFKYTRVRRKQNIIKKIKQYLIEDSDKNLFPYFLKKSLLIAISFIMFIVLINFLILGSKRNPNNNLYAQNTDNSKSTSEVYNKILDEVKEMKIETNNIVTEEDIKDIPAVASTPVASVEKASDAFYDYLVSDNSLVSDGTISLKYDEYTIEEGDNLTSISKKIGANLDTIVSVNKISNANKLRPGQTIMIPNRNGLLYIVKKNETLEEISDRYDVELNRVLSFNKIDRDNINTGDEIFLPGAKYTLDERIDKFGQMFSLPTVVTRISSVFGYRVHPITGVRRKHLGVDIPGGLNTPIYAARKGKVIFAGYSGGFGNLVIVRHDKGYTTYYGHLNKITTTVGANVGVGVMIGRMGSTGNSTGSHLHFEVRRNGVALNPADFIPIGKFIKRR
>NC_018607|1994918:2029773|1998495_1999836_-|WP_013244841.1|DBSCAN-SWA
MPKILVIDDEKNIRDGIKKSLEYEGYEVVTAENGEKGIETVYKGGIDLVITDLKMPEKTGEEFLHDILEFDKHIPVIILTGHGNIETAVDMMRLGAYDFMTKPFNIDKMLLIIARALENKNIKKTNETLEKRVDYHESFYGMIGHSSKMLKVYEAIKQVARTKATVLIEGESGTGKELVANAIHQISDRAKQPYITVNCAALSEGVLESELFGHEKGSFTGAIDKKIGRFEAANKGTIFLDEIGEINQVVQVKLLRVLEERVIERVGSNTPISVDIRVIAATNKKLSEEIKEGRFREDLYYRLNVIKIEMPPLRERREDIPLLIDNFIKEFSQVHNIEITNVDKKVYKLLSSLQWEGNVRELRNTVETMVVMSKDGKIDESNIPNWVLTSSTDDFIIDKEMTLEELEKKYINHLLSKNNFNKAQVAKILGIERATLYRKLKDYNVD

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014936408.1|1994918_1995518_+|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_013244845.1|1995514_1996111_+|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_013244844.1|1996103_1996391_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_013244843.1|1996462_1997530_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_013244842.1|1997611_1998076_+	PTS glucose transporter subunit IIA	NA	NA	NA	NA
WP_013244841.1|1998495_1999836_-	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_014936409.1|1999839_2001030_-	two-component sensor histidine kinase	NA	NA	NA	NA
2000422:2000439	attL	NA	NA	NA	NA
WP_013244839.1|2001182_2001716_+	peptide deformylase	E3SLL2	Synechococcus_phage	1.6e-18	43.1
WP_014936410.1|2001724_2002405_+	HAD family hydrolase	NA	NA	NA	NA
WP_014936411.1|2002923_2004534_-	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013244834.1|2004829_2005849_-	CapA family protein	NA	NA	NA	NA
WP_014936412.1|2006054_2007233_+	M23 family metallopeptidase	A0A292GJG6	Xanthomonas_phage	1.2e-21	42.0
WP_014936413.1|2008211_2009375_-|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_014936414.1|2009500_2010475_-	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_014936416.1|2011826_2012051_-	hypothetical protein	NA	NA	NA	NA
WP_014936417.1|2012296_2014126_-	hypothetical protein	NA	NA	NA	NA
WP_014936418.1|2014163_2014700_-	hypothetical protein	NA	NA	NA	NA
WP_013244393.1|2014724_2015150_-	hypothetical protein	NA	NA	NA	NA
WP_014936419.1|2015153_2015747_-	glycoside hydrolase family 19 protein	A0A191ZC60	Erwinia_phage	3.4e-30	43.9
WP_014936421.1|2016147_2016543_-	RNA polymerase	NA	NA	NA	NA
WP_014936422.1|2016539_2016737_-	hypothetical protein	NA	NA	NA	NA
WP_014936423.1|2016754_2018695_-	hypothetical protein	NA	NA	NA	NA
2017592:2017609	attR	NA	NA	NA	NA
WP_014936424.1|2018704_2019790_-	hypothetical protein	NA	NA	NA	NA
WP_014936425.1|2019789_2020242_-	hypothetical protein	NA	NA	NA	NA
WP_014936428.1|2021057_2024531_-|tail	phage tail tape measure protein	A0A1L6BY19	Clostridium_phage	1.2e-61	38.4
WP_041747756.1|2024555_2024741_-	hypothetical protein	NA	NA	NA	NA
WP_014936429.1|2024787_2025147_-	hypothetical protein	NA	NA	NA	NA
WP_014936430.1|2025171_2026260_-	hypothetical protein	NA	NA	NA	NA
WP_014936431.1|2026271_2026640_-	hypothetical protein	NA	NA	NA	NA
WP_014936432.1|2026636_2027107_-	hypothetical protein	NA	NA	NA	NA
WP_014936433.1|2027108_2027450_-|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_014936434.1|2027446_2027812_-|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_014936435.1|2027838_2029140_-|capsid	phage major capsid protein	A0A142K632	Streptomyces_phage	2.2e-53	35.4
WP_014936436.1|2029149_2029773_-|head,protease	HK97 family phage prohead protease	A0A2H4J6Z9	uncultured_Caudovirales_phage	3.7e-27	42.2