CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_018642	Listeria monocytogenes L312, complete genome	2 crisprs	DinG,cas3,WYL,casR,DEDDh,RT,csa3	0	0	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_018642_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018642_1

501262-501690

Orphan

Consensus_repeat	Method
GATGTAAGTAATTTTAATACGAG	CRISPRCasFinder
GATNTAAGTNNTTTTGATACNAGTTCNGTNACTNNNATG	CRT

5 spacers

The CRISPR arrays of NC_018642_1

>merge|NC_018642|1|501262-501690|CRISPRCasFinder,CRT
GATTTGAGTGGTCTTGATACTAGTGCGGTAACTACTATGTGGGATATGTTTAACAGCTGTAGGGCACTTGAGGAACTGGATGTAAGTCATTTTGATACGAGTTCAGTAACTGATATGTATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTAGATGTAAGTAATTTCGATACCAGTTCCGCTACTGCAATGGTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTGGATGTAAGTAATTTTAATACGAGCTTAGTAACTGATATGCGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGCGTTAGATGTAAGTAATTTTGATACGAGTTCAGTAACTAATATGGCTGCCATGTTTTCTGATAATGAAAAACTGGAGAAGCTTGATTTAAGTACCTTTGATACCAGTTCAGTGACTAACATG

>NC_018642|1|1|501262-501674|CRISPRCasFinder
GATTTGAGTGGTCTTGATACTAG	TGCGGTAACTACTATGTGGGATATGTTTAACAGCTGTAGGGCACTTGAGGAACTG
GATGTAAGTCATTTTGATACGAG	TTCAGTAACTGATATGTATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTA
GATGTAAGTAATTTCGATACCAG	TTCCGCTACTGCAATGGTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTG
GATGTAAGTAATTTTAATACGAG	CTTAGTAACTGATATGCGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGCGTTA
GATGTAAGTAATTTTGATACGAG	TTCAGTAACTAATATGGCTGCCATGTTTTCTGATAATGAAAAACTGGAGAAGCTT
GATTTAAGTACCTTTGATACCAG

>NC_018642|1|1|501262-501690|CRT
GATTTGAGTGGTCTTGATACTAGTGCGGTAACTACTATG	TGGGATATGTTTAACAGCTGTAGGGCACTTGAGGAACTG
GATGTAAGTCATTTTGATACGAGTTCAGTAACTGATATG	TATAGAGTGTTTAATGGCTGTGAAAAACTGAAGAAACTA
GATGTAAGTAATTTCGATACCAGTTCCGCTACTGCAATG	GTTCAAATGTTTAGAAATTGTAGCGCCCTTGAGAAGTTG
GATGTAAGTAATTTTAATACGAGCTTAGTAACTGATATG	CGTGCCATGTTTGCTGGTTGTACTAGTCTTGAAGCGTTA
GATGTAAGTAATTTTGATACGAGTTCAGTAACTAATATG	GCTGCCATGTTTTCTGATAATGAAAAACTGGAGAAGCTT
GATTTAAGTACCTTTGATACCAGTTCAGTGACTAACATG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018642.1\|WP_003734632.1\|485010_485766_-\|DUF4866-family-protein	unknown	unknown	gnl\|CDD\|379782
NC_018642.1\|WP_003728092.1\|494400_495951_+\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NC_018642.1\|WP_003725186.1\|485882_488042_-\|transglutaminase	unknown	unknown	gnl\|CDD\|376628
NC_018642.1\|WP_003728992.1\|492023_493307_+\|cytosine-permease	unknown	unknown	gnl\|CDD\|271377
NC_018642.1\|WP_003734634.1\|488038_489187_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NC_018642.1\|WP_012681110.1\|510607_511435_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368573
NC_018642.1\|WP_012681107.1\|502652_504413_+\|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl\|CDD\|308794
NC_018642.1\|WP_003728090.1\|496586_498125_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|368260
NC_018642.1\|WP_003734773.1\|507792_508140_+\|hypothetical-protein	unknown	unknown	unknown
NC_018642.1\|WP_003740428.1\|490294_491890_+\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225306
NC_018642.1\|WP_003728455.1\|504478_504952_+\|hypothetical-protein	unknown	unknown	unknown
NC_018642.1\|WP_003721253.1\|504971_505457_+\|hypothetical-protein	unknown	unknown	unknown
NC_018642.1\|WP_003740435.1\|505484_505790_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NC_018642.1\|WP_003734774.1\|508543_508786_+\|hypothetical-protein	unknown	unknown	unknown
NC_018642.1\|WP_012681109.1\|508868_509846_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004
NC_018642.1\|WP_012681108.1\|505865_506132_+\|transposase	unknown	unknown	unknown
NC_018642.1\|WP_003721242.1\|489191_490139_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_018642.1\|WP_003728093.1\|493307_494408_+\|DUF917-domain-containing-protein	unknown	unknown	gnl\|CDD\|226065
NC_018642.1\|WP_014952534.1\|498387_500469_+\|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl\|CDD\|308794
NC_018642.1\|WP_003734772.1\|506865_507483_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_018642.1\|WP_003734632.1\|485010_485766_-\|DUF4866-family-protein	gnl\|CDD\|379782	pfam16160, DUF4866, Domain of unknown function (DUF4866). This family consists of uncharacterized proteins around 250 residues in length and is mainly found in various human gut Firmicute species and abundant in human gut metagenomic datasets. The function of this family is unknown.	2.71521e-121
NC_018642.1\|WP_003728092.1\|494400_495951_+\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.15698e-106
NC_018642.1\|WP_003725186.1\|485882_488042_-\|transglutaminase	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	4.40206e-28
NC_018642.1\|WP_003728992.1\|492023_493307_+\|cytosine-permease	gnl\|CDD\|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	1.15029e-95
NC_018642.1\|WP_003734634.1\|488038_489187_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	7.03616e-53
NC_018642.1\|WP_012681107.1\|502652_504413_+\|BspA-family-leucine-rich-repeat-surface-protein	gnl\|CDD\|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	7.96941e-29
NC_018642.1\|WP_003728090.1\|496586_498125_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|368260	pfam05043, Mga, Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins. This is presumably a DNA-binding domain.	1.06475e-18
NC_018642.1\|WP_012681110.1\|510607_511435_+\|hypothetical-protein	gnl\|CDD\|368573	pfam05708, Peptidase_C92, Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family. Amidase_YiiX is a family of permuted papain-like amidases. It has amidase specificity for the amide bond between a lipid and an amino acid (or peptide). From the structure, a tetramer, each monomer is made up of a layered alpha-beta fold with a central, 6-stranded, antiparallel beta-sheet that is protected by helices on either side. The catalytic Cys154 in UniProtKB:Q74NK7, Structure 3kw0, is located on the N-terminus of helix alphaF. The two additional helices located above Cys154 contribute to the formation of the active site, where the lysine ligand is bound.	0.00019582
NC_018642.1\|WP_003740428.1\|490294_491890_+\|PucR-family-transcriptional-regulator	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	2.42853e-59
NC_018642.1\|WP_003740435.1\|505484_505790_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	4.51255e-05
NC_018642.1\|WP_012681109.1\|508868_509846_-\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	2.46397e-44
NC_018642.1\|WP_003721242.1\|489191_490139_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	7.47241e-102
NC_018642.1\|WP_003728093.1\|493307_494408_+\|DUF917-domain-containing-protein	gnl\|CDD\|226065	COG3535, COG3535, Uncharacterized conserved protein [Function unknown].	0
NC_018642.1\|WP_014952534.1\|498387_500469_+\|BspA-family-leucine-rich-repeat-surface-protein	gnl\|CDD\|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	4.65057e-29

>NC_018642.1|WP_014952534.1|498387_500469_+|BspA-family-leucine-rich-repeat-surface-protein
MKKFSMRVVLIISVLFIALGNANVSIAQERDTTNKLPEEELGSLDTSNLIAEEVAQEKPAEVENLEEIPTTDELMQNPDVREQSVADSDDPDLTAVSSGDYWTIYYNSANDEYSLRMFGNVPSSKPSAWNSYLKYIKHIEIEEATLTGDFSSYFRSNVFTVLESVRIERSNLSGVTSFARAFEGDSESESPLEKVIIRDNYYPETPSLTNISRMFTLCRKLSELDVSGLNTSSVTKMDTIFSNANSLKELDVSHFDTSSVTDMSSMFAACNSLEELDVSNFDTSSVTNMKYMLSGLHLKKLDVSNFDTSSVTNMYGMFAYCYNLEELDVSNFDTSSVNNMLHMFYVCNNLEELDLSNFDTSSVTNMFAMFAYCTSLKEIDVSNFDTSSVTTMSAMFFECSSLEALDLSNFDTSSVTTMASMFENSTALKSLYLDNFTDAASMTDMFKGTTSLTYLFVSHNLSTFNRLENTSWYDEKNWVQFSNLSQLQTYHRKQSEPTGYRKGAFLSLTMDAMGGEFEDAEEQKVQNKVSGEYWEEIVPVKEDYYFDGWYLDQNFTNKFDFSLPAAVSTTIYAKWVENYTVIIPASISLNEATELKVEGINRGSKALSVGLNRLATSVSESNELTLANTADTTVQCSAPLSWDGSENNPEKAILTLAPGSEITEGDAVMAIEAPENIQAGKYTGNLVFSINYE
>NC_018642.1|WP_003728090.1|496586_498125_+|helix-turn-helix-domain-containing-protein
MREYLDSKSQKKVALLEKIFYAENHTSTQEELLNDLNITYPTLISTIKTINFDIERFGYKAFSIVHSAPNLSYTLKISDNCSIQLIINAYIRESPKFQILETLLLASFPNLQALAKKVHVSYSGIKKEIKELNEELSERNLYISTGNQVEITGDEFSLRIFYAFLFLVAYSGDRWPFSFVRYDEITDLLESCPKEIYRANSIDKAMMIHYYVAMHLLRDRMNCQIDTTRQFKVALYKACTEESKKSESAFIKKVAKQLPNRNYKEMTYTTQIILSTIVAFGSYSSIEKMPSFFYMDEQLEEMGFMKLVDFASERVNDNLSIPFSEKEMELLRYSFASINYRYFLLDNLINKFNNIVPGYTDLDRNIRKIHKVNHLEPLISQLVNLKEMDPLKPFEERLTSDYLIILDKRIDFSIHTLPIKVTILSTISNETAVFDFMRYFSSYYNLEIINQVDPVVDLYISDFSVSPEVLTSLRINQPIIYVNTRWLESDYVKINDNLAKIARKKFIANKKD
>NC_018642.1|WP_003728092.1|494400_495951_+|hydantoinase/oxoprolinase-family-protein
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTHAMLGTTQCTNAIVERKKLAKVGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYEYDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKNDQELAVQKIIEEELGADIPVSISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIAHAEIYLCQNDGTLMSLNYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDVGGVRTNFRMPDIISIGLGGGSIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAVRLGRAEIGNPELVAHIPTDFAEKAYKKIAEMTEDAIDKMKTSSGSVSLVLVGGGSVIIPDEISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLAGAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV
>NC_018642.1|WP_003728093.1|493307_494408_+|DUF917-domain-containing-protein
MRYLDEQAIENIAIGAAFLGTGGGGDPYIGKMMALTAIKKHGPIKLLSPEEIADDDYFIPAAMMGAPSVLIEKFPKGDEFVRVFEKLGRYVGKEVKGTFPMEAGGVNSMIPIVVAAQLGLPMVDCDGMGRAFPELQMVTFHLDGISATPMAITDEKGNIGIMETIDNKWTERLARVTTVEMGASSLVSLYPCNGAQIKQSSIKNIVTLSEEIGKVIRETSMDEAEKLQKLLDVTHGYHLFEGKITDVVRETRAGFNFGRVKIDGLNKDTGSEVIVHFQNENLVAEKNGEPIAITPDLICMVDLETLMPVTTEALKYGKRVRVMALPADDAWRTDKGIETVGPRYFGYDVDFEPLEELVKKEERRHV
>NC_018642.1|WP_003728992.1|492023_493307_+|cytosine-permease
MTEKKSVEQTQSWQSLAFVWTGAMICVPSLLVGGTLISGMPLWEAILIALLGYGVIVLFMIYQGMQSSDLGIPAVSVASQVFGEQGSKKIISILLAIACLGWFGIQANVCGAAFSQFLGIYGINLPVPVSSLIWGVIMLLSAIYGIRILSILNYIAVPVLLFVCIYGLVVSLNDGGLAIVENYKPAGSMSFMTGLAITIGSFALGAVIAGDYSQYTKSRKDVVKAAIVGILPSGVLMITVGAVLALTAGTADISVVFTNLGLPVLGIIGLILAAWTTNAVNAFSGGIAIINVFNISEKYHKVAVAVAGGLGTILAVIGILNHFVPIMSVLSAMVPPVAGVMIASYWIVQKGDKSKWAPVSGVNWLGVSSWLVGAVIAGIPVILTFFPELPQLPNQPLIGIILSLAVYLIGAKVLSGKTNNVENLEGK
>NC_018642.1|WP_003740428.1|490294_491890_+|PucR-family-transcriptional-regulator
MSVKLADLMKLPSLKEAKVVSGKSGLSKLVSSISVLEYTEVALLEDDLFDNDEFYGSEIVVSAFVNIRDDVEAQCRTIERLHKVGEVALILYYVGIFVPKMDQKLIDFANELDFTIIVMPENEMSLRYSEVIYEVVEAIVKQEMTDTNFVTESLEQISSVRPPQRNIDTTLKILSDRTHTSLVLTDNSFQVINSITWPRTRHWDFERIIEASKQIGEHELVQLTLDERDFYTARKPIFQDGMQAMHLFMMKEKGVLTADVVMQITEVVQVFMNLWGRNYVEISTAELMKAILNDESVKMRRLGKILNVDVSSIKWMWLVKTEEIRDNEQVLAELKSFVASHFQVSLIDLFEDNIVVLLDNSVAQRDRTHTANEFAMMMKEHGIDLKITVCQGMEQTSDVQSAYSLVNEYKNAANAIYANKSIYSLQEIDFAAKCVEIVDRGELAIAEQMRPLKPLEDNDELIETLSVFLLEGESNYNQAAELLFLHKNTIKYRIQRINELLQYPATKIPESYNLYLAVAIRRILGGNNNNK
>NC_018642.1|WP_003721242.1|489191_490139_-|MoxR-family-ATPase
MSIEPSIKIEEIINEVEKVIVGKRHVVKLSLTALLAGGHVLLEDVPGVGKTMMVRTLSKTIGVSFKRIQFTPDLLPADVTGVSIFNPETRDFEFRPGPVMGNIVLADEINRTAPRTQAALLEGMAENSVTVDGITRKLANPFFVMATQNPIEYEGTYALPEAQLDRFLLKINIGYPTVEEEMQLLTLKQYQDPLDQTQQVVTLSELLDLKNKAKQVFIDDVLKNYIIRLVDATRKHPSVALGISPRGSLAFMQAAQAFALIEGRDYVIPDDIQYLAPYIFTHRLILKSEAYYNEETAESIIASILKNTSVPVEKR
>NC_018642.1|WP_003734634.1|488038_489187_-|DUF58-domain-containing-protein
MLKKRLLLAFRWIIMLIIYAGLWTYTLFQGDTASWFLTYFFSFILLLLFLSSIYPLKAWKVNRRFVKNTYHDGDLVDMQVSFTRKSRYPVGYLLFQQKIPASFGNVSARQQVVYPLFKKHFTVTLAGFVGVRGIHSFPPVDVETSDAFGLLERSRQLSSEKSLTIYPTYFPDVLEKISEASPENERNAAYWTLKKNSNLHSLREFSSGDRISLIDWKSSAKSDQLMTREFENSATSRLSVIFYGASHPNFELSLRAAYSFIRKISEDNGEIRVTLLGDQTSKFAPAKGTSRLQDISTAFAEIAPVDSLTLQESLDSNLHSGEKILLFTPCIDTMLMQKVTRLTDNKQLQIITFQSEHSKAMDAPAIFLEPASLLSRWEREAK
>NC_018642.1|WP_003725186.1|485882_488042_-|transglutaminase
MKRYLTLVMLFILSVLLISEWIYPFAELTELSTANWIILFITLSLGSFFLRLKYYWTIPLHIVMIIFVSGIYYAKGGILAGNWFVSFFQITFNGFRDMVQFRSSDISMDFILIVFLIALWLLSYITTYSILRKQRVMSVLVLTVAYLAVINTFTDYNSNWAIVRTVLEGFLLLHLALASRIAAPNRISADSLKRNGLFYHIFVILLLAVFVFSSLMLPKKAPIFPDPVPTIKNALGINTTRTVGYSEDDTTLGGALKKDNATVFTARAEKGHYWRVESKTVYTGTGWANANSADVISFSSGDNFPIQLTEQTTGATNTAEISFASSNDYMPYPYGTQTVNGAVDSFSANLTIERVGPVDTIKNYTVQLKTPVYNIEKMQNADFSTLSNAFVSQYTQTPKDLPDRVTKLANKVTKDADSIYDKTKAIERYLSASGTFTYSTEDAKETPRGADYVDQFLFETQIGYCDNFSTSMVVMLRSLGIPARWAKGYTPGEGEKKENDAKTTYTITNNNAHSWPEVFFPGTGWVPFEPTATFSNPENFQEPTTETANKPETPNDSTSTPETPNTADKTPEQDNGSSSTGETPKKEEPKTETAASNFEIPSWVWWIPAGLVVTLLALAIIFRRRIRRYLLLRSLRNSPEFGKTYHRLMKLLASYGYVRESSETLRHFSTRVDAELTTTEFSRLTKMYEAQIYSNNLTEKVITAEETQLVQQVIARLTK
>NC_018642.1|WP_003734632.1|485010_485766_-|DUF4866-family-protein
MTTIFPKEQNVAPLFEQILANPTACRRFKDVFLDNLESYQETRGFEKDDTLFAKIILSAYRQSDVSALLLGVCGRTLFELLRQAFLIPKKLTVDNPFFLTDKEGNFIAKKDDISNREQEKFQEIYQSDLHHSETTIFLVDDDDIIHSYEPDFSISTKRINKKRGILVLYSLPDTLKLGMTESEVYAFIWKTFLHIQEIIPSSRIFYGQETSENADELGVFLPIHHFEKKMLQNIEQVNELVDALREQMVNK
>NC_018642.1|WP_012681107.1|502652_504413_+|BspA-family-leucine-rich-repeat-surface-protein
MKKFSMRVVLIISVLFIAFGSANVSIAQERDTTNKLPEEELGSLDTSNIIAEEVAQEKPAEVEQLEEIPTTDELMQNPDVLEKSVADSDDPDLTVVSSGDFWTIYRNTVNNEYNLRMFGNVPSSRPTAWNSYLKSIKHIEIEEATLTGSFASYFRGTDFPVLESVRIEQCNLSGVTSFEMAFYNSGIEKVIIRDNDYPKAPSLLTATQYMFSLCRNLSELDLSGLDTSAVTNMYAMFQNCTSLEELDLSNFDTSSATNMYSMFSGCRSLEKLDVSNFDTSSVAHMQFMFEKCSILEELDLSNFDTSSVTNMSYMFQLCPALKSLYLDNFTDAAIMTGMFAGTTSLTYLFVSHNLSTFNNLENTSWYDEKNWVQFSNLSQLQTYHRQQSEPIGYRKGAFLSLTMDAMGGEFEDAEEQKVQNKISGEYWEEVIPVKEGHYFDGWYLDQNFTNKFDFSLPAAVSTTIYAKWVENYTVIIPASISLNEASELKVQGINRGSKTLSVGLNYEETTISESNKLTLSNTADTTVRCLAPMSWDGSETNPEKAILTLAPGSEITEGDAVMEIKSPENIQAGKYTGNVVFSIKYE
>NC_018642.1|WP_003728455.1|504478_504952_+|hypothetical-protein
MKKKRVVIISLLLLLVSVIGISSYFLFKDKINLLDVDHSAVEWNGKKQKDTSGEENTIAIPGFEKVTLYANETTQAVNFHNPEINDCYFKISLIHPDGSVLWISDLIEPGKGMYSIELEKTLAVGEYENAVLKYECFSLNDQSPLNGSEINLKLVVV
>NC_018642.1|WP_003721253.1|504971_505457_+|hypothetical-protein
MNKLVLSTLSVAAMGMVFFSGGTAYAADKEGNTVVEYSVEGDYTLVVPEKVNLSNDNATEMSVKTINRNLEPGKEVEVTLSSGLSADGEIELQRVGAISDVITSSFKSNNSVVPMANPVIGSFSGYAMEETEVSKIQIGNPQGDKKAGAYQTTLTFTAAFK
>NC_018642.1|WP_003740435.1|505484_505790_+|LPXTG-cell-wall-anchor-domain-containing-protein
MKRKLVLAMVLISFCGMFLLSPERVQASQTVVEVFISEDDLDVSEENIQEIPKKELAASSDKDNKQPILPKAGDTVTNYTLLGLVLVLIWLIMQRKRKKKE
>NC_018642.1|WP_012681108.1|505865_506132_+|transposase
MARIEYGEEIQKSLLVLYSRGSTIQSICKEYGIPRYEFHKWMKLHDADKLETKEVKTFLQIRELKQQKNKLEEEILFLNEAINLLESP
>NC_018642.1|WP_003734772.1|506865_507483_+|hypothetical-protein
MLMSLSVLPLATYASETENTPTESYDGENFIATQTGNTLVIEDKKTGETVKIEMNDEENGVITSDDGTIENVHRDEEGNVYVDNELELEAPPLDIEDGINIATQPRLLKASKWIYVQTTKYNTTTQGNMRSLALGILSFMPITGPIFGIVAIIDAARSMGAKTLYVRVKQYRTSGYQFYKYDSYYYANASLTKLVKKTSQTKRMW
>NC_018642.1|WP_003734773.1|507792_508140_+|hypothetical-protein
MQKDTYSGIRLSVIQLIDSKKENLKENNIKLTIIKDEKDGYVVELDNDKCMAEIVVEEPTYAPYRYISFEVVSLMDGKVKIIYSWYDDETSQWSDIEKELNKGIQFLNNFKTMEQ
>NC_018642.1|WP_003734774.1|508543_508786_+|hypothetical-protein
MKRIILTSTLIVWTIVCIYMSISMVSNNTGIAFPIWLHIILLICFLATGIVNVKKKEYLWSTMLFEGVLVVLLSLIIVLV
>NC_018642.1|WP_012681109.1|508868_509846_-|HD-domain-containing-protein
MKITDPLYGTFEIEPVLAELIQSPLVSRLAYVHQGGSSYLVNPLWDLSRLDHSIGVMLFIRKFGGSLEEQIAGLLHDVSHTAFSHVVDYALDFEEEDYHEQIFEDFVKTSTIPAILEKYGYSFEGIFDDISKWKILEQEAPELCADRIDYTLQDLYRHGKISLAEVEEFLQALVMVDGRLYLANIALAEWFVAQYYSEVIDYFYDPLNVYSYEILAEAMRIAFQQETITTADLRLTDTELLAKLNANSDAREKIQLLASAHLEENEADFTYHHKKKMRLINPSILVDGRLIPADELSENVREMNDWASERSKHGIYIKATKKSKQ
>NC_018642.1|WP_012681110.1|510607_511435_+|hypothetical-protein
MKKRLIGIITALLLVSGILLSPQMAQAETKVDYDALYQQGVSEGIINKADVSLETWIKENESEYNQVYQDGLKDGVYDASLSYEEWIKLNNYGQPPVVDENWEEVPQKPMLKGVYKGYNIKKGDILITNGTSSSGLLGHAAIANGNEYILDIPGAGKTTRQVPTSKWMSDYDPEGWVKVYRLKDSSVANAAANWADKNYYSTKGTSKQNIFPKYGMTGSRYSKNPTYCSKIVLQAYYFGTGNKPVVQVFPSLVTVYDLPNYFSKAYKPQQVKYFK

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Crispr_ID: NC_018642_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_018642_2

2104310-2104597

Orphan

Consensus_repeat	Method
ACATATTAGTAACGGAACTCGTATCAAAATTACTTACATCCAATTTCTCAAGTG	PILER-CR

3 spacers

The CRISPR arrays of NC_018642_2

>merge|NC_018642|2|2104310-2104597|PILER-CR
ACATAGTAGTAACGGAACTCGTATCAAAATTGCTTACATCCAATTTCTCAAGTGCTCTACAGGAACTAAACAAGGCTGACATATTAGTAACGGAACTCGTATCAAAATTACTTACATCTAATTCTTTAAGACTGGTACTATTAACAAACATGCCTCCCATATTAGTAACGGAACTCGTATCAAAATTACTTACATCCAATTTTTCAAGTGCTTTACAATCCCTAAACATATGATACATATCATTCACAGAACTCGTATCAAAATTACTTACATTCAATTTCTCAAGTG

>NC_018642|2|1|2104310-2104597|PILER-CR
ACATAGTAGTAACGGAACTCGTATCAAAATTGCTTACATCCAATTTCTCAAGTG	CTCTACAGGAACTAAACAAGGCTG
ACATATTAGTAACGGAACTCGTATCAAAATTACTTACATCTAATTCTTTAAGAC	TGGTACTATTAACAAACATGCCTCCCATATTAG
TAACGGAACTCGTATCAAAATTACTTACATCCAATTTTTCAAGTGCTTTACAAT	CCCTAAACATATGATACATATCAT
TCACAGAACTCGTATCAAAATTACTTACATTCAATTTCTCAAGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_018642.1\|WP_003724067.1\|2111014_2111473_-\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|224712
NC_018642.1\|WP_014952578.1\|2098989_2100828_-\|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl\|CDD\|308794
NC_018642.1\|WP_003725774.1\|2093720_2094821_+\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NC_018642.1\|WP_003721253.1\|2095818_2096304_-\|hypothetical-protein	unknown	unknown	unknown
NC_018642.1\|WP_003728335.1\|2113526_2114807_-\|cell-division-protein-FtsA	unknown	unknown	gnl\|CDD\|223918
NC_018642.1\|WP_003725775.1\|2095144_2095411_-\|hypothetical-protein	unknown	unknown	unknown
NC_018642.1\|WP_003728090.1\|2105664_2107203_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|368260
NC_018642.1\|WP_003730798.1\|2091427_2092882_+\|L-aspartate-oxidase	unknown	unknown	gnl\|CDD\|236147
NC_018642.1\|WP_012681384.1\|2109800_2110577_-\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|225185
NC_018642.1\|WP_003724066.1\|2110701_2110992_-\|YggT-family-protein	unknown	unknown	gnl\|CDD\|376765
NC_018642.1\|WP_003725773.1\|2092878_2093724_+\|carboxylating-nicotinate-nucleotide-diphosphorylase	unknown	unknown	gnl\|CDD\|181221
NC_018642.1\|WP_003725196.1\|2096323_2096797_-\|hypothetical-protein	unknown	unknown	unknown
NC_018642.1\|WP_003728337.1\|2108031_2108625_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_018642.1\|WP_014952579.1\|2100962_2103113_-\|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl\|CDD\|308794
NC_018642.1\|WP_003728333.1\|2116005_2117097_-\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|234825
NC_018642.1\|WP_012681378.1\|2096862_2098854_-\|BspA-family-leucine-rich-repeat-surface-protein	unknown	unknown	gnl\|CDD\|308794
NC_018642.1\|WP_014952580.1\|2107224_2108004_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|316372
NC_018642.1\|WP_003728828.1\|2112284_2113460_-\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468
NC_018642.1\|WP_003727952.1\|2095485_2095791_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NC_018642.1\|WP_012681385.1\|2111476_2112166_-\|YggS-family-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223402

Protein	Function_ID	Function_description	E-value
NC_018642.1\|WP_014952578.1\|2098989_2100828_-\|BspA-family-leucine-rich-repeat-surface-protein	gnl\|CDD\|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	1.82475e-34
NC_018642.1\|WP_003725774.1\|2093720_2094821_+\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	7.8764e-150
NC_018642.1\|WP_003728335.1\|2113526_2114807_-\|cell-division-protein-FtsA	gnl\|CDD\|223918	COG0849, ftsA, Cell division ATPase FtsA [Cell division and chromosome partitioning].	8.66919e-161
NC_018642.1\|WP_003728090.1\|2105664_2107203_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|368260	pfam05043, Mga, Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins. This is presumably a DNA-binding domain.	1.06475e-18
NC_018642.1\|WP_003730798.1\|2091427_2092882_+\|L-aspartate-oxidase	gnl\|CDD\|236147	PRK08071, PRK08071, L-aspartate oxidase; Provisional.	0
NC_018642.1\|WP_012681384.1\|2109800_2110577_-\|RNA-binding-protein	gnl\|CDD\|225185	COG2302, COG2302, Uncharacterized conserved protein, contains S4-like domain [Function unknown].	5.25746e-131
NC_018642.1\|WP_003724066.1\|2110701_2110992_-\|YggT-family-protein	gnl\|CDD\|376765	pfam02325, YGGT, YGGT family. This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown.	3.52749e-09
NC_018642.1\|WP_003725773.1\|2092878_2093724_+\|carboxylating-nicotinate-nucleotide-diphosphorylase	gnl\|CDD\|181221	PRK08072, PRK08072, carboxylating nicotinate-nucleotide diphosphorylase.	0
NC_018642.1\|WP_014952579.1\|2100962_2103113_-\|BspA-family-leucine-rich-repeat-surface-protein	gnl\|CDD\|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	2.47728e-32
NC_018642.1\|WP_003728337.1\|2108031_2108625_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.0655e-06
NC_018642.1\|WP_003724067.1\|2111014_2111473_-\|cell-division-protein-SepF	gnl\|CDD\|224712	COG1799, COG1799, Uncharacterized protein conserved in bacteria [Function unknown].	5.62658e-53
NC_018642.1\|WP_003728333.1\|2116005_2117097_-\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	gnl\|CDD\|234825	PRK00726, murG, undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional.	1.16143e-161
NC_018642.1\|WP_012681378.1\|2096862_2098854_-\|BspA-family-leucine-rich-repeat-surface-protein	gnl\|CDD\|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	9.13135e-32
NC_018642.1\|WP_014952580.1\|2107224_2108004_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|316372	pfam13847, Methyltransf_31, Methyltransferase domain. This family appears to have methyltransferase activity.	2.54328e-12
NC_018642.1\|WP_003728828.1\|2112284_2113460_-\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	0
NC_018642.1\|WP_003727952.1\|2095485_2095791_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	0.000635685
NC_018642.1\|WP_012681385.1\|2111476_2112166_-\|YggS-family-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223402	COG0325, COG0325, Predicted enzyme with a TIM-barrel fold [General function prediction only].	4.98022e-107

>NC_018642.1|WP_014952579.1|2100962_2103113_-|BspA-family-leucine-rich-repeat-surface-protein
MKKFSMRVVLIISVLFITFGSANVSTAQERDTANKLPEVELGSLDTSNIIAEEVTQEKPAEVEQLEEIPTTDELMQNPNVLEKSVADSDDPDLTVVSSGAYWTIYYNSANGEYSLRMFGNVPSSKPTAWNSYLSNIKHIEIEEATLTGSFEAYFRDNVFTVLESVRIEQCNLSGVTSFRSAFEGQLALEKVIIRDNYYPTTPTLRTTENMFLGCYNLREFDVSGLDTRAVTNMRAMFQNCTSLEELDVSNFDTSSVTTMQNMFQNCTSLEELDVSNFDTSSVTTMQNMFQNCTSLEELDVSNFDTRSVTSMAYMFYRSAGLKELDVSNFNTSSVTAIQGMFYDCSSLEELDVSNFDTRSVTSMTFMFLNCANLEELDVSNFNTRSVTSMTYMFGGCTSLKELDLSNFNTSSVTAMYNMFQNSTSLEELDLSNFNTSSVTNMSYMFQNCTALKSLYLDNFTTPKTMTDMFIGTTSLTYLFVSHNFKDFNGVENTNWFDEKNGVQFSNLSQLQTYHQQQREPTGYRKGVFLSLTMDAMGGQFEDAEEQKVQNKVSGEYWEEVVPVKEGHYFDGWYLDRNFTNKFDFSLPVAVSTTIYAKWVENYTVVIPASISLNEATELKVEGINRGSKTLSVGLNYEETTISESNKLTLANTADTTVQCLAPLSWDGSETNPEKVILTLAPGSEITEGDAVMAIEAPENIQAGTYTGNLVFSINYE
>NC_018642.1|WP_014952578.1|2098989_2100828_-|BspA-family-leucine-rich-repeat-surface-protein
MKKFSMRVVLIISVLFIAFGSANVSIAQEMDTTNKLPEEELGSLDTSNLIAEEVAQDKPAEVDNLEEIPTTDELMQNPEVLEQPVVDSDDPDLTVVSSGDFWTLYYNSANDEYSMRMFGNVPSSKPTAWNSYLKYIKHIEIEEATLTGSFASYFDNSAFPALESVRIEQCNLSGVTSFRTAFNNHLTLEKVIIKDNDYPTTSSLLTTEYMFSHAIKLTELDVSGLDTSAVTNMKNMFGGCNSLEELDLSNFDTSSVTNMSGMFGYCESLEKLNVSHLDTSSVTDMNAMFYGCTSLEALDVSNFDTSSVTDMRAMFADNEKLEKLDLSTFDTSSVTNMGTMFKDCTALKSLYLDNFTDAAIMTDMFKGTTSLTYLFVSHNLSTFTSLENTSWYDEKNWVQFSNLSQLQTYHRKQSEPTGYRKGAFLSLTMDAMGGEFEDAEEQKVQSKISGEYWEEVIPVKEGHYFDGWYLDQNFTNKFDFSLPATVSATLYAKWVENYTVVIPASISLNEATELKVEGINRGDKNLSVGLNRTATSVSESNKLTLANTADTTIQCLAPLSWDGSENNPKNAILTLAPGSEITEGEAVMAIEAPENIQAGTYTGNLVFSINYE
>NC_018642.1|WP_012681378.1|2096862_2098854_-|BspA-family-leucine-rich-repeat-surface-protein
MKKFSMRVVLIISVLFIAFGSANVSIAQEMDTTNKLPEEELGSLYTSNLITEEVAQDKPAEVEQLEEIPTTDELMQNPDVLEQPVADSDDPDLTVVSSGAYWTIYRNTVNGEYSLHMFGNVPSSRPTAWNSYLKSIKHIEIEEATLTGNFASYFDNSAFPALESVRIEQCNLSGVTSFASAFYSSGIEKVIIRDNDYPTAPSLLTTQSMFGYANKLTELDVSGLDTSAVTNMQNMFQYCRALEELDVSHFDTSSVTTMRGMFQYCELLDKLDVSNWDTSSVTTMMSAFAECNSLEILDVSNFDTSSVTDMTAMFQNCYALEKLNISNFDTSSVTKMYAMFSGLYEVGKLDASNFDTSLVTTMNRMFQNCKSLKELDIGNFNTSLVTDMDRMFINCAALKSLYLDNFTTAKTMTDMFTGTTSLTYLFVSHNLSTFTGLENTSWYDEKNWVQFSNLSQLQTYHRKQSEPTGYRKGEFLSLTMDAMGGEFEDAEEQKVQSKISGEYWEEVIPVKEGHYFDGWYLDQNFTNKFDFSLPAAVSTTIYAKWIENYTVIIPASISLNETSELKVEGINRGDKNLSVGLNRTATSISESNKLTLSNTADATVQCLVPLSWDGSENNPENAILTLAPGSEITEGDAVMEIKSPENIQAGKYTGNVVFSIKYD
>NC_018642.1|WP_003725196.1|2096323_2096797_-|hypothetical-protein
MKKKRVVIISLLLLLVSVIGISSYFLFKDKINLLDVDHSAVDWNGKKQKDTSGEENTIAIPGFEKVTLYANETTQAVNFHNPEINDCYFKISLIHPDGSVLWISDLIEPGKGMYSIELEKTLAVGEYENAVLKYECFSLNDQSPLNGSEINLKLVVV
>NC_018642.1|WP_003721253.1|2095818_2096304_-|hypothetical-protein
MNKLVLSTLSVAAMGMVFFSGGTAYAADKEGNTVVEYSVEGDYTLVVPEKVNLSNDNATEMSVKTINRNLEPGKEVEVTLSSGLSADGEIELQRVGAISDVITSSFKSNNSVVPMANPVIGSFSGYAMEETEVSKIQIGNPQGDKKAGAYQTTLTFTAAFK
>NC_018642.1|WP_003727952.1|2095485_2095791_-|LPXTG-cell-wall-anchor-domain-containing-protein
MKRKLVLAMVLISFCGMFLLSPERVQASQTVVEVFISEDDLDVSEENIQEIPKKELAASSDKDNKQPILPKAGDTVTNYTLLGLVLVLIWLIMQRRSKKKE
>NC_018642.1|WP_003725775.1|2095144_2095411_-|hypothetical-protein
MARIEYEEKIQKSLLVLYFRGSTIQSICREYGIPRYEFHKWMKLHDADKLETKEVKTFLQIRELKQQKNKLEEEILFLNEAINLLESP
>NC_018642.1|WP_003725774.1|2093720_2094821_+|quinolinate-synthase-NadA
MNLLETVEQDTMPTHYKQMTQAEMIARVTEIKAQLGENLFIPCHHYQKDEVVPFADAIGDSLQLAQIAAQNKKAKHIVFCGVHFMAETADMLTTSEQIVTLPDMRAGCSMADMADIHQLTNAWPKLQTLFGDTILPVTYINSTAAIKSFVGEHGGTTVTSSNATKIVSWALEQKERIFFLPDQHLGRNTAFELGIPLEHMAIWNPIKNELEYEGNLDDCKVILWKGYCSVHQHFTVKNIENIRKNNPKMRIIVHPECTHEVVSLADDSGSTKKIVTEINNAAPGTEWAVGTEANLVGRIIQENPDKKIVSLNPFMCPCMTMNRIDLPHLLWTLEAIQNGEQRNQIKVDKQTTKFALKALERMLQLS
>NC_018642.1|WP_003725773.1|2092878_2093724_+|carboxylating-nicotinate-nucleotide-diphosphorylase
MNSILMNQAIQAFLLEDIGQHDLSAETVFPRDTMGEGVFLAKETGILCGISIPPKVYELLGGNIQFEAYKKDGDWIQKGDIIAAVTAPVRTLLSGERVILNLMQRMSGIASQTNFAVKQLDDSAIRICDTRKTAPGLRAFDKYAVQTGGGFNHRNGLYDGVMLKDNHIAFSGGITSAVSTVREKLGHMVKIEVETETAEQVKEAVQAGADIIMFDNRTPEEIKQLVKLVPPHITTEISGNVTLENIHRYKGSGANYLSLGSLTHSVRAFDISFNSKGGIKA
>NC_018642.1|WP_003730798.1|2091427_2092882_+|L-aspartate-oxidase
MTKERVIIIGSGIAGCTAAFRLMHDYDVTIITKGLKEESNSMLAQGGVAAAVSKNDTPKKHFSDTFQAGCFHNKVLAVNQLVTNGPIVIQKLIAEGMTFDEQNGELSLGLEGAHQLPRILHTGGDQTGKFLTTFLQEKLTNIHWQEQKMAIEIIKQNDSAIGVHCLDKENRLHTYYGEHIILASGGLGQLFPVTTNAATISGDGLALAYRAGAKLTDMEFIQFHPTLLFLNGRCHGLISEAVRGEGAKLIRADGSAVMTDVHPRADLAPRDIVAATLFAEIQDGNEVFLDITPIPNFEERFPGITANLDAYHVPFRETKRIPVHPGAHFLMGGIRTDLQGKTNIPGLYAIGEVANAGVHGANRLASNSLLETLVFGEKVAEYILTQKTNLIDHPEIPLSNQTQTPHLPDKQLLQEKIWETLGITRKPEKITEFLHWLTDFDYANHTRETAEISHMLITAKLIAESALKRTESLGAHRILKGVIK
>NC_018642.1|WP_003728090.1|2105664_2107203_-|helix-turn-helix-domain-containing-protein
MREYLDSKSQKKVALLEKIFYAENHTSTQEELLNDLNITYPTLISTIKTINFDIERFGYKAFSIVHSAPNLSYTLKISDNCSIQLIINAYIRESPKFQILETLLLASFPNLQALAKKVHVSYSGIKKEIKELNEELSERNLYISTGNQVEITGDEFSLRIFYAFLFLVAYSGDRWPFSFVRYDEITDLLESCPKEIYRANSIDKAMMIHYYVAMHLLRDRMNCQIDTTRQFKVALYKACTEESKKSESAFIKKVAKQLPNRNYKEMTYTTQIILSTIVAFGSYSSIEKMPSFFYMDEQLEEMGFMKLVDFASERVNDNLSIPFSEKEMELLRYSFASINYRYFLLDNLINKFNNIVPGYTDLDRNIRKIHKVNHLEPLISQLVNLKEMDPLKPFEERLTSDYLIILDKRIDFSIHTLPIKVTILSTISNETAVFDFMRYFSSYYNLEIINQVDPVVDLYISDFSVSPEVLTSLRINQPIIYVNTRWLESDYVKINDNLAKIARKKFIANKKD
>NC_018642.1|WP_014952580.1|2107224_2108004_-|methyltransferase-domain-containing-protein
MNKETERKLAASLTSQSIEILPFILYFLQDFFELGSSPKDITYLIKQHMPLSAESNFLDLACGKGAVSIGIAKELGNPVKGIDLIPAFIEEAKCKAKEAQVESLCQFEVGDVNKSVQNEKNYDAVIFGAAADILGNPAETLEKLQGTVKEGGYIIIDEAYVPELAHNNQVKYQNYEYLTRKEWLNLFEQNQLQLVEELEGTAEVDFELEKQHLLTRANELIQQYPEKKALFEGYLKSQWSEYDDLEEYLIAVTWILHKK
>NC_018642.1|WP_003728337.1|2108031_2108625_-|TetR/AcrR-family-transcriptional-regulator
MPKLVTGYERQQTKNLIIEHTSHLIYIKKGIQGFTVEDITRAARIGKRKFYTCFPSKEACLFEVVEYSYQAQLEAFKKIMEEKGSLKSKMTRFLKEVYLSEKSINNYFSPEDFHAILQKLPPTYTEREERMTSEVLETAMTYIDLTRAQWEALVMLLDCLTYTATRSYVETAKKAKEETLDILIHSIADYVEKQTQC
>NC_018642.1|WP_012681384.1|2109800_2110577_-|RNA-binding-protein
MDGIYQHFRAEEYAFIDKILGITMQVENEYTPQLTDFLDPRQRFITETVIGGYDEINVQFFGGVAHAERRRALIYPDYYTPTEADFEIALFHIRYPVKFTTLTHQKILGTLMSLGMKRDIFGDILNNGSEWQLLVESTMKDYLTLQLEKIGKVNVMLEETDLANAVYAPVVWEEMGLTVSSMRLDVIISNVHHISRQKAKQLVTAGLVKVNWKTVENPDFECEEEDVLSARGYGRVKVLSTGGRTKKDKIRIEIGYLK
>NC_018642.1|WP_003724066.1|2110701_2110992_-|YggT-family-protein
MQSILYQVVEIILFIIRWLPTLMFIYFLMSWFPGARESKIGQFLARIFEPILEPFRRIIPPIGMFDISSLVAYFIFQYAMRVLTGLIQVYVIPMLF
>NC_018642.1|WP_003724067.1|2111014_2111473_-|cell-division-protein-SepF
MGLSNKFKSFFFLDEEEEYYEEEVAREPEPMQKKTKKEKPNKNRFYAVEEDDAKVVSMQGAQFSSRMVLAEPRVYAEAQELADYLKEYKSVVVNLQRISHDQATRIVDFLSGTVYALGGDIQRVGNNIFLCTPDNVEVDGSISEMLDEQNFM
>NC_018642.1|WP_012681385.1|2111476_2112166_-|YggS-family-pyridoxal-phosphate-dependent-enzyme
MTKQANLQKVTAQIERACEESNRQPEDVTLVAVTKTIDVAGITELYDLGIRHFGENRADVFQEKTVALADKEDICWHYIGSLQTRKVKDVLPKIDYLHSLDRSSLAKEIEKRATKQVKCFLQVNISGEESKHGFSKEEALSFLQEANFTFIEIVGLMTMAPITNSDIELHHVFHELKQLQQEIHALQLNNIPCTELSMGMTNDYGVAITEGATFIRVGRALVSDDNMEV
>NC_018642.1|WP_003728828.1|2112284_2113460_-|cell-division-protein-FtsZ
MLEFDTSSESLATIKVIGVGGGGNNAVNRMIEHGVQGVEFISVNTDAQALNLAKAETKLQIGTKLTRGLGAGAVPEIGKKAAEESREQIEEALKGSDMVFVTAGMGGGTGTGAAPVIAQIAKEMGALTVGVVTRPFGFEGPKRTKQALTGTEAMKEAVDTLIVIPNDRLLQIVDKNTPMLEAFREADNVLRQGVQGISDLIAVPGLINLDFADVKTIMTNRGSALMGIGIATGENRAAEAAKKAISSPLLETSVDGAKGVLMNITGGSNLSLYEVQEAAEIVSSASDEDVNMIFGSVINDELKDELIVTVIATGFDEEKQAQQQAQANRRPNQSIQVNRPNYAVQDEQQNDYAQNAPQQANAPVHEQQAEPQQNSSDVDVPAFIRNRNRRG
>NC_018642.1|WP_003728335.1|2113526_2114807_-|cell-division-protein-FtsA
MGDSEIYVSLDIGTASVKVIIAEMADDRLNIIGVGNVESSGIKKGIIIDIDKTVESIKKAIEQAERMVGVEISQVIVGVVSSQVHLEACRGIVAVGSENREITDEDVWNVMDAAQVVPLSPEREIINTIPDQFVVDGLTGITDPRGMIGVRLEMEGTLITGSKTILHNTLRCVERAGLEISDIALQPLAEASISLSEDDKEFGTALVNVGAGTTTVSVFEQGRLTYTGVIPVGGDNITKDLSLGLNTSTANADRVKLDHGYAFYDDASPDEVFAIDVIGSDQKQHFTQVEVADIIEARMEEIFQLVVEELTRVGKTHLPGGYVLTGGSMAIPGAIDLAGKTLAAHVRLAIPDYIGVREPSFTTAVGLIKYAYQMAELEGRDVSSSASEPRYDDEAPKQKQPKPKQKKSDDEKVSTKMKNFFGAFFE
>NC_018642.1|WP_003728333.1|2116005_2117097_-|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase
MKVAISGGGTGGHVYPALALIRELKKIHPEAEFLYIGTEKGLEAGIVKREGIPFEAIEITGFKRSLSLENIKTVMRFLSGAKKSKQILRDFKPDVVIGTGGYVCGPVVYAAAKLKIPTLIHEQNSVAGLTNKFLSRYTDKVAICFEEVSDSFASEKIVFTGNPRASEVVGVDSEGALETYGLVSGKPTVLVFGGSRGARGVNEAVEAILPEWNNRDFQLLYVTGDVHYEKIKDSLAELNLGNHISVQPFIYDMPKILNAVTLVVSRAGATTLAELTALGVPSILIPSPYVTANHQENNARALEKNNAAIVITEAELKNTDLMATVDSILNDEAKLNGMKLSAKQMGRPDAAAKLVEAVLSIMK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

123377 : 129904

Listeria_phage(33.33%)

tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003728215.1\|123377_123830_-	ImmA/IrrE family metallo-endopeptidase	A0A059T7S0	Listeria_phage	4.0e-31	47.9
WP_003721740.1\|123835_124171_-	helix-turn-helix transcriptional regulator	A0A2H4JAR9	uncultured_Caudovirales_phage	4.0e-20	52.5
WP_003724946.1\|124387_124816_+	hypothetical protein	NA	NA	NA	NA
WP_003724947.1\|124827_125244_+	hypothetical protein	A8ASQ1	Listeria_phage	1.3e-20	38.6
WP_003728212.1\|125523_125913_+	DUF5072 family protein	NA	NA	NA	NA
WP_003721744.1\|125925_126438_+\|tail	phage major tail protein, TP901-1 family	A0A097PBF4	Streptococcus_pyogenes_phage	1.2e-47	62.7
WP_003721745.1\|126485_126788_+	hypothetical protein	NA	NA	NA	NA
WP_003740367.1\|126829_127234_+	hypothetical protein	NA	NA	NA	NA
WP_003731178.1\|127220_129089_+	membrane protein	A0A097PAU2	Streptococcus_pyogenes_phage	3.5e-20	45.8
WP_003724951.1\|129085_129904_+\|tail	phage tail family protein	A0A2H4JAE4	uncultured_Caudovirales_phage	1.7e-40	34.9

DBSCAN-SWA_2

1271743 : 1328595

Bacillus_virus(16.67%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003734523.1\|1271743_1272883_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_003723563.1\|1272962_1273358_-	helix-turn-helix transcriptional regulator	A9D9J6	Lactobacillus_prophage	1.3e-14	57.4
WP_003727524.1\|1273508_1273724_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_003727523.1\|1273847_1274381_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_003731300.1\|1274396_1275062_+	hypothetical protein	NA	NA	NA	NA
WP_003727521.1\|1275323_1276262_+	hypothetical protein	NA	NA	NA	NA
WP_003723884.1\|1276376_1277660_+	trigger factor	NA	NA	NA	NA
WP_003723886.1\|1277844_1279104_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.4e-145	63.2
WP_003726393.1\|1279222_1279789_+	type I signal peptidase SipX	NA	NA	NA	NA
WP_003726394.1\|1279823_1280393_+	type I signal peptidase SipY	NA	NA	NA	NA
WP_003727520.1\|1280494_1281037_+	type I signal peptidase SipZ	NA	NA	NA	NA
WP_003726396.1\|1281046_1281910_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_003727519.1\|1281906_1282692_+	ribonuclease HII	G4YAY0	Emiliania_huxleyi_virus	6.7e-26	37.6
WP_012681270.1\|1282825_1283686_+	DNA-protecting protein DprA	NA	NA	NA	NA
WP_003727517.1\|1283958_1286037_+	type I DNA topoisomerase	A0A1V0SB35	Catovirus	5.4e-107	37.5
WP_003726401.1\|1286099_1287404_+\|tRNA	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	NA	NA	NA	NA
WP_003731303.1\|1287686_1288589_+	tyrosine recombinase XerC	A0A142K7N4	Mycobacterium_phage	1.8e-14	29.5
WP_003724001.1\|1288609_1289149_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_003727514.1\|1289162_1290572_+\|protease	ATP-dependent protease ATPase subunit HslU	W6AS21	Erwinia_phage	7.5e-44	27.8
WP_003726695.1\|1290592_1291372_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_003726696.1\|1291474_1291894_+	acyl-CoA thioesterase	NA	NA	NA	NA
WP_003724130.1\|1291916_1292228_+	hypothetical protein	NA	NA	NA	NA
WP_003726697.1\|1292230_1293103_+	aldose 1-epimerase family protein	NA	NA	NA	NA
WP_003726698.1\|1293144_1293741_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_003727511.1\|1293898_1294306_+	CoA-binding protein	NA	NA	NA	NA
WP_003727510.1\|1294486_1296454_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	5.1e-123	42.5
WP_003727509.1\|1296450_1298910_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	1.1e-101	31.8
WP_003726814.1\|1298992_1299460_+	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_009917681.1\|1300087_1301908_+	class 1 internalin InlK	NA	NA	NA	NA
WP_003727507.1\|1301940_1303827_-	peptidoglycan O-acetyltransferase OatA	B5WZU0	Pseudomonas_phage	3.8e-43	32.2
WP_003726657.1\|1304039_1304738_+	glycerophosphodiester phosphodiesterase	A0A0S2MYI4	Enterococcus_phage	6.4e-12	31.9
WP_003723738.1\|1304970_1306647_+	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_003726658.1\|1306773_1307691_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_003719566.1\|1307812_1308046_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_012681271.1\|1308156_1309380_+	GTPase HflX	NA	NA	NA	NA
WP_003727505.1\|1309372_1310599_+	methionine gamma-lyase family protein	NA	NA	NA	NA
WP_003719570.1\|1310800_1311169_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_003723435.1\|1311239_1312574_+	type I glutamate--ammonia ligase	A0A1V0SJ53	Klosneuvirus	2.0e-06	26.4
WP_003726564.1\|1312717_1314013_+	arsenic transporter	A0A2H4PQU3	Staphylococcus_phage	2.5e-147	62.6
WP_003726565.1\|1314046_1314571_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_003723438.1\|1314601_1315216_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	9.3e-15	62.1
WP_003726566.1\|1315372_1315702_+	cell division suppressor protein YneA	NA	NA	NA	NA
WP_003726567.1\|1315795_1316023_+	DUF896 domain-containing protein	NA	NA	NA	NA
WP_012681272.1\|1316169_1318164_+	transketolase	NA	NA	NA	NA
WP_003726667.1\|1318384_1318624_+	YneF family protein	NA	NA	NA	NA
WP_003726668.1\|1318672_1319404_-	class I SAM-dependent methyltransferase	A0A1X9I6N4	Streptococcus_phage	2.3e-81	58.0
WP_003726669.1\|1319425_1319932_-	ParB-like nuclease domain-containing protein	A0A220GKT8	Streptococcus_phage	1.4e-56	66.7
WP_003727499.1\|1319941_1321246_-	DUF3440 domain-containing protein	A0A220GKF8	Streptococcus_phage	1.2e-133	52.1
WP_012681273.1\|1321235_1322441_-	helicase SNF2	L0P6E9	Lactobacillus_phage	7.0e-91	46.6
WP_003727498.1\|1322418_1322793_-	hypothetical protein	NA	NA	NA	NA
WP_003723449.1\|1323085_1323814_+	UMP kinase	NA	NA	NA	NA
WP_003723450.1\|1323813_1324371_+	ribosome recycling factor	NA	NA	NA	NA
WP_003727497.1\|1324601_1325360_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	4.4e-22	42.1
WP_003727496.1\|1325373_1326162_+	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_003726414.1\|1326176_1327319_+	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_003726415.1\|1327332_1328595_+\|protease	RIP metalloprotease RseP	NA	NA	NA	NA

DBSCAN-SWA_3

1824302 : 1832588

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003731569.1\|1824302_1824869_-	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	2.8e-26	38.5
WP_003726210.1\|1824865_1825915_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	3.2e-63	44.4
WP_012681342.1\|1825933_1827361_-	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	1.4e-53	31.9
WP_003731570.1\|1827345_1829565_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	6.5e-159	40.8
WP_003726212.1\|1829557_1830241_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_003722248.1\|1830244_1830490_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_003726214.1\|1830501_1831215_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	2.0e-40	38.3
WP_003729814.1\|1831295_1832588_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	2.5e-17	33.0

DBSCAN-SWA_4

2519416 : 2527261

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003725407.1\|2519416_2520388_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	5.2e-52	39.4
WP_003734495.1\|2520395_2521364_-	YvcK family protein	A1IMD5	Streptococcus_phage	1.8e-68	43.6
WP_003722606.1\|2521365_2522241_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	1.9e-08	29.7
WP_003725409.1\|2522348_2524079_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	9.5e-174	53.1
WP_003741152.1\|2524120_2525182_-	galactose mutarotase	NA	NA	NA	NA
WP_003725411.1\|2525198_2526182_-	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	4.0e-52	38.1
WP_003722610.1\|2526301_2527261_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.0e-88	53.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_018642

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection