CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_019689	Pleurocapsa sp. PCC 7327, complete sequence	14 crisprs	cas14j,Cas14c_CAS-V-F,Cas14u_CAS-V,csa3,c2c10_CAS-V-U3,csx1,csm3gr7,cmr5gr11,cmr4gr7,cmr3gr5,WYL,csx18,cas1,cas2,c2c9_V-U4,csc2gr7,csc1gr5,cas3,cas6,cas4	0	12	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_019689_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_1

41636-41839

Orphan

Consensus_repeat	Method
ANTTGCGTTTGTTGNAGNTGCGAT	CRT
TTGCGTTTGTTGCAGTTGCGATCGCGCCTGTTCTAATTCGACTTGCGTTTGTTGC	CRISPRCasFinder

4 spacers

The CRISPR arrays of NC_019689_1

>merge|NC_019689|1|41636-41839|CRT,CRISPRCasFinder
ATTCTGGTTCGTTGTAGCTGCGATCGCATTTGTTCTAAGTTGACTTGCGTTTGTTGCAGTTGCGATCGCGCCTGTTCTAATTCGACTTGCGTTTGTTGCAATTGCAATTGCAATTGCAATTGTGCTTGCTTTGATTCGGTTTGCGTTTGTTGTAGTTGCGATCGCGCCTGTTCTAATTCGACTTGCGTTTGTTGCTGCTGAGAG

>NC_019689|1|1|41636-41839|CRT
ATTCTGGTTCGTTGTAGCTGCGAT	CGCATTTGTTCTAAGTTG
ACTTGCGTTTGTTGCAGTTGCGAT	CGCGCCTGTTCTAATTCG
ACTTGCGTTTGTTGCAATTGCAAT	TGCAATTGCAATTGTGCTTGCTTTGATTCG
GTTTGCGTTTGTTGTAGTTGCGAT	CGCGCCTGTTCTAATTCG
ACTTGCGTTTGTTGCTGCTGAGAG

>NC_019689|1|1|41638-41830|CRISPRCasFinder
TCTGGTTCGTTGTAGCTGCGATCGCATTTGTTCTAAGTTGACTTGCGTTTGTTGC	AGTTGCGATCGCGCCTGTTCTAATTCGACTTGCGTTTGTTGCAATTGCAATTGCAATTGCAATTGTGCTTGCTTTGATTCGGT
TTGCGTTTGTTGTAGTTGCGATCGCGCCTGTTCTAATTCGACTTGCGTTTGTTGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015141842.1\|50502_51138_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239314
NC_019689.1\|WP_015141825.1\|27593_28382_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015141831.1\|35564_36644_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340838
NC_019689.1\|WP_015141833.1\|37782_39576_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133027
NC_019689.1\|WP_015141843.1\|51212_52160_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|274884
NC_019689.1\|WP_015141844.1\|52203_52896_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|234670
NC_019689.1\|WP_041392514.1\|31282_32026_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015141826.1\|28383_29412_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|132997
NC_019689.1\|WP_015141835.1\|42717_44121_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213187
NC_019689.1\|WP_041392520.1\|47896_49486_-\|alkaline-phosphatase-D-family-protein	unknown	unknown	gnl\|CDD\|226070
NC_019689.1\|WP_186005353.1\|25813_25960_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015141839.1\|46683_47691_+\|chlorophyll-synthase-ChlG	unknown	unknown	gnl\|CDD\|215028
NC_019689.1\|WP_015141829.1\|32202_34638_+\|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234804
NC_019689.1\|WP_015141827.1\|29435_31217_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238461
NC_019689.1\|WP_015141841.1\|49546_49927_-\|photosystem-II-complex-extrinsic-protein-PsbU	unknown	unknown	gnl\|CDD\|235048
NC_019689.1\|WP_015141832.1\|36689_37550_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NC_019689.1\|WP_015141837.1\|45318_45513_+\|DUF2862-domain-containing-protein	unknown	unknown	gnl\|CDD\|371361
NC_019689.1\|WP_015141824.1\|26027_27557_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl\|CDD\|129465
NC_019689.1\|WP_015141838.1\|45552_46650_+\|ArsA-family-ATPase	unknown	unknown	gnl\|CDD\|349755
NC_019689.1\|WP_015141836.1\|44145_44991_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224596

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015141842.1\|50502_51138_+\|peroxiredoxin	gnl\|CDD\|239314	cd03016, PRX_1cys, Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by reducing and detoxifying hydrogen peroxide, peroxynitrite, and organic hydroperoxides. As with all other PRXs, a cysteine sulfenic acid intermediate is formed upon reaction of 1-cys PRX with its substrates. Having no resolving cysteine, the oxidized enzyme is resolved by an external small-molecule or protein reductant such as thioredoxin or glutaredoxin. Similar to typical 2-cys PRX, 1-cys PRX forms a functional dimeric unit with a B-type interface, as well as a decameric structure which is stabilized in the reduced form of the enzyme. Other oligomeric forms, tetramers and hexamers, have also been reported. Mammalian 1-cys PRX is localized cellularly in the cytosol and is expressed at high levels in brain, eye, testes and lung. The seed-specific plant 1-cys PRXs protect tissues from reactive oxygen species during desiccation and are also called rehydrins.	4.42656e-137
NC_019689.1\|WP_015141841.1\|49546_49927_-\|photosystem-II-complex-extrinsic-protein-PsbU	gnl\|CDD\|235048	PRK02515, psbU, photosystem II complex extrinsic protein PsbU.	9.94979e-63
NC_019689.1\|WP_015141831.1\|35564_36644_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340838	cd03809, GT4_MtfB-like, glycosyltransferases MtfB, WbpX, and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.	1.21949e-100
NC_019689.1\|WP_015141833.1\|37782_39576_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133027	cd04184, GT2_RfbC_Mx_like, Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis. The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.	7.07583e-124
NC_019689.1\|WP_015141843.1\|51212_52160_-\|glycosyltransferase	gnl\|CDD\|274884	TIGR03965, glycosyltransferase_Rv0696_family, mycofactocin system glycosyltransferase. Members of this protein family are putative glycosyltransferases, members of pfam00535 (glycosyl transferase family 2). Members appear mostly in the Actinobacteria, where they appear to be part of a system for converting a precursor peptide (TIGR03969) into a novel redox carrier designated mycofactocin. A radical SAM enzyme, TIGR03962, is a proposed to be a key maturase for mycofactocin.	7.32631e-44
NC_019689.1\|WP_015141844.1\|52203_52896_-\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|234670	PRK00155, ispD, D-ribitol-5-phosphate cytidylyltransferase.	8.06221e-116
NC_019689.1\|WP_015141835.1\|42717_44121_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213187	cd03220, ABC_KpsT_Wzt, ATP-binding cassette component of polysaccharide transport system. The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2.	3.07466e-108
NC_019689.1\|WP_041392520.1\|47896_49486_-\|alkaline-phosphatase-D-family-protein	gnl\|CDD\|226070	COG3540, PhoD, Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism].	0
NC_019689.1\|WP_015141826.1\|28383_29412_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|132997	cd00761, Glyco_tranf_GTA_type, Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.	3.98912e-22
NC_019689.1\|WP_015141839.1\|46683_47691_+\|chlorophyll-synthase-ChlG	gnl\|CDD\|215028	PLN00012, PLN00012, chlorophyll synthetase; Provisional.	0
NC_019689.1\|WP_015141829.1\|32202_34638_+\|phenylalanine--tRNA-ligase-subunit-beta	gnl\|CDD\|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	0
NC_019689.1\|WP_015141827.1\|29435_31217_-\|hypothetical-protein	gnl\|CDD\|238461	cd00919, Heme_Cu_Oxidase_I, Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is diverse in terms of electron donors, subunit composition, and heme types. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. It has been proposed that Archaea acquired heme-copper oxidases through gene transfer from Gram-positive bacteria. Membership in the superfamily is defined by subunit I, which contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme and a copper ion. It also contains a low-spin heme, believed to participate in the transfer of electrons to the binuclear center. Only subunit I is common to the entire superfamily. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from the electron donor on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I of cytochrome c oxidase (CcO) and ubiquinol oxidase. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electron transfer occurs in two segments: from the electron donor to the low-spin heme, and from the low-spin heme to the binuclear center. The first segment can be a multi-step process and varies among the different families, while the second segment, a direct transfer, is consistent throughout the superfamily.	0.000333587
NC_019689.1\|WP_015141836.1\|44145_44991_-\|ABC-transporter-permease	gnl\|CDD\|224596	COG1682, TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	7.9825e-46
NC_019689.1\|WP_015141832.1\|36689_37550_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	1.30622e-28
NC_019689.1\|WP_015141824.1\|26027_27557_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl\|CDD\|129465	TIGR00368, Uncharacterized_protein_YifB, Mg chelatase-related protein. The N-terminal end matches very strongly a pfam Mg_chelatase domain. [Unknown function, General].	0
NC_019689.1\|WP_015141838.1\|45552_46650_+\|ArsA-family-ATPase	gnl\|CDD\|349755	cd02035, ArsA, Arsenical pump-driving ATPase ArsA. ArsA ATPase functions as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two subunits, the catalytic ArsA subunit and the membrane subunit ArsB, which are encoded by arsA and arsB genes, respectively. Arsenic efflux in bacteria is catalyzed by either ArsB alone or by ArsAB complex. The ATP-coupled pump, however, is more efficient. ArsA is composed of two homologous halves, A1 and A2, connected by a short linker sequence.	4.37912e-64
NC_019689.1\|WP_015141837.1\|45318_45513_+\|DUF2862-domain-containing-protein	gnl\|CDD\|371361	pfam11061, DUF2862, Protein of unknown function (DUF2862). This family of proteins has no known function.	4.94237e-31

>NC_019689.1|WP_015141833.1|37782_39576_-|glycosyltransferase-family-2-protein
MQIVAIFQKLDRLKYLSARQGTRRLLRYLYQRAISNVKSRRDYQKWIKQNCLTNEDIAAARVEIETWQLRPKFSVIMPVYNVEAKWLKKAIDSVRKQIYPNWELCIADDASSKPHIREILTHYTQIDERIKVTFRIENGQISAASNSALELTTGDYIALLDHDDELTIDALFENAKLINQHPDADFIYSDEDKIDARGNRFNPVFKPDWSPEYFYSTMYTCHLGVVRTSLIRKIGGFRSEYDGSQDYDLILRIVEKTNNIYHIPKILYHWRNITVSAASGSLAKPWAFAAGKKALEAMLERSLYQGRVKETANPGIYRVRRDIIGHPLVSIIISSTGKIIDTPSGSRCLLENCIDSIEQLSSYRNYEIIVVDGCELPESALETISSANSFLVRCTELFNFSIGINQGAAKAKGEFLLLLNDDTEIITPDWLESMLELAQQKEIGAVGAKLLSPDGYIRHTGIILLEGNPCYAFYGFDSAHSGYHCSNIVNRNYLAVTGACLMMRRELFQQLGGMDENFPLDYNDVDLCLAAHQAGYRNVVTPYAQLICYTSTSSKNRLKTGELEQLKTKWKHYLNGLTRDPYYNPNLSKRVSNFEMF
>NC_019689.1|WP_015141832.1|36689_37550_-|glycosyltransferase-family-2-protein
MPALYFLTVNYHSTELVDNLIQSISRYKNIPYQIVIVNNSPENKSIYFIKNKYLFILDSPKNLGFGGACNLGLNWIYTQNPKAIVWIINPDACLLENNFKKLIQFFNNYSEVSIFGTIIYNAVKKIWFAGGRFIPATGAIFTEDLVSNTDSAYVPCDWVSGCSLIINLRNFSECPQFDSAYFLYYEDFDFCRRYANQGHLVAVTKQFSVIHQPSSITDRNPFQKIKHSTYSYLLTLERYTNKLFFILRLIRLTFNASVLIFIKPKKALGKVAGILNYFMRSHRVSL
>NC_019689.1|WP_015141831.1|35564_36644_-|glycosyltransferase-family-4-protein
MSDLLVNLAVVFSKPTGISNYARNLFLYLKNLNSTLLTPQKYSEFNCYLIPDNLSPAYGTKGHFRRLLWTQFHLPPIYKKLQSKLLFSPIPEAPIYTDCHFIVMVHDLIPLRFLKRFSPLTPYFRYYIPQVLDRAEHIICNSVATAKDITEFYRISSAKITPILLAYDANHFRKLNMPSKDEQPPYFLYLGRHDPYKNLHRLIDAFAKIPDRDCQLWLAGPPDKRYTPKLQAQVEALSLRDRVKFLDYVPYEQLPILLNQALALVFPSLWEGFGLPVLEAMGCGTPVITSNLSSLPEVAGDAALLIDPYNVEEITAAMASVAEDSGLRSRLSTLSLERASQFSWAKTGRATVEVLQRYL
>NC_019689.1|WP_015141829.1|32202_34638_+|phenylalanine--tRNA-ligase-subunit-beta
MRISVNWLRELVDVTLAPEELAETLTIAGLEVEEIEDRRQLADGVVIGKIVERQPHPNADKLSVCQVDIGQPTPLNIVCGAPNARADIYVPVATVNTYLPAVDLKIRPTKLRGVRSEGMICSLAELGLEKESAGIHIFSQENLKLGGDVRPLLGLDDVIIDISPTANRADALSMVGVAREVAALTGASLHLPKVSPISIPAGDGILSLKVADKQACPAYIGTVIEGVKIATSPEWLQRRLQAAGVRPINNVVDATNYILLEWGQPLHAFDRDRTQALAGGDSLTIGVRFARENESLKTLDGQTRSLKPQNLLITANDRPIALAGVMGGEETEVHPGTQNIILEAALFDPVATRRSSRAQSLRTESSARYERGVNQAELDIACHRAIALIVELAGGTPIAQTIADGRENTKSQSIQLRLARVHQVLGAVKRDNAIGQIEAEDVERILTDLGCQLELVSTKDKVWTVTVPPHRCRDLEREIDLIEEVARLFGYDRFIDKLPDKTEPGGLSFEDRAQRQLREAFRAVGLTEVVQYSLVKPEKDEVVLANPLFVEYSALRTNLLDGLIDAFEYNQSQGNGALNAFEIGRIFSRSEDGVREADSIAGILGGDLMSEGRWSRSGKPAPMTWYEAKGILESVFARLGLAVEYQPDRKDARLHPGRTASLWWGGKRLGTFGQLHPQLRQQRGLLDAVYAFEMSCSVLLEALAREDLQTPRFRPYSTYPALERDLAFFSPVKVSVVELEMAMKKAAGGLLDKVELFDEYRGENVPDGQRSLAFSLAYRSSDRTLTDAEVEPVHNKIREALVERFNVLLRS
>NC_019689.1|WP_041392514.1|31282_32026_-|hypothetical-protein
MLVFVIPLKSPQVSRSWERVCQLFERTVRSACNQTSPNFHVIVVCHEKPNIEFTHPKITYLEVDFPLPKETNPVARGDTDKGRKILKGLIYAAQFSPSHTMAVDADDCVNQHLAEFVEQYPQNNGWYVSRGYKYQENTSYVYLTRKNFYRMCGTSNILRYDLNFLPENPEYNRGYGYYKYYILHARVRDVLTEKGMPLAPLPFAGAIYILGYGDNVYGNAKNFSFNFFNRRKLTKSIREEFCLSSIV
>NC_019689.1|WP_015141827.1|29435_31217_-|hypothetical-protein
MVRAKKLKLKTSQVFTELFGDLRETREKPLDLKEKLAEKRKAKEERKKLLGIVGIAIAFAIVVGLPLVLLVGTRPAAIVATGIPSLLLCYNYPRLALWVFLIYMPFSGTITYWIGGGNALFQLSKDAIYVPALIALVVQCKRKRLPILIPKQLLPTLGLLLFSCLLTLFLVNGMQELLPYCQDLGPNERYALDAAGNYILNERGLVVLNPCKEGSPFFQGVLGLKVLLGYVPLIFCTYYLINDKKKLLLLGRILVMLAIACCLLGLAQYWMLKTGRCVGTRNLMGNDLFKPTVEAKCLVGGALLYSPQVGQIRLPGTFVSPWHWAWFLVANAGICFATAFSDTSFIWRAAGLTGMGLVFVNAVVSGQRLALAAVPVLIAVLLVLTGQIANLKRFIPIGVGLTLVLFLFFSFLNPDFIQERIDSFVGRWNTSPPQQFIQQQFQYALANQTGILGRGLGKATNSTRVFGPVSLVETFHPKLLFEIGWPGLIAFMIFITHLTILSFKSYRSVRDRALYSFGSSFWVFMLIIGYFPYWYPLDTDPVAVYYWLFAGVLFKLPEIDKQEREKLKAVKGKNSSRSKNKKSNLRKKKLSAA
>NC_019689.1|WP_015141826.1|28383_29412_-|glycosyltransferase-family-2-protein
MVFPSISIIIPTYRREEPLQETLEDVLKQDYSAFEVLVIDQTPTHTPTVEAYLEQLAESGKIRWFRVNWASLPGARNYGVRRATGEIILFIDDDVKLPEGYLQAHARNYQERPEIGAVAGRVFDRMKLADSQKINPKDSPYSIDYLPPQAMDPGIAWYYIDLVHTVKPQRVISTRGCNMSFRRDIFTERGIWFDERFRGSAVREESDFCLRLRQTGYHIWYDPEAYLVHLGEETGGCHDINTRSLQYQLTFYHNHFLMALKNLTPVQQLRLYAKLFDCHVLGNPPCNKGGSPIKILTRGIFYSLGFLDALSTLVKSLWENGQIYSRQDLEGSAVPVTQQAKV
>NC_019689.1|WP_015141825.1|27593_28382_-|hypothetical-protein
MIEGNNCTIDRAASGKLIFAGTLLIAAVFSPLPLAAQISNIDIPYMAFYDHQGTYASTIGIGTSAAQALTEVSPQTISAQRLTGETLPASALSFRYSPQVTMQVRDRIAEQFAAQSPEQAVQIRCEFAQADVVGEFRRLIQRYGYDPDNLAHNMAAFLILQWEVLTETQAQPPQMKGAAEQVAEALLAGSLLHGMSDADKQTVADSMAYQALMSVLVFNDLKQRGDSTGIARLREGIIRSARELGWDFNRIELTSRGFVAAR
>NC_019689.1|WP_015141824.1|26027_27557_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MLARVWSASIVGIDAVKVAVEVDVSGGLPGIALVGLPDAAVQESKERVKSAIKNAGFAFPVRKIVVNLAPADLRKEGPIFDLPISIGILAASEQANAQLLEDYLFLGEVSLDGSLRPVAGVLPIAAAAQKMGIQGLIVPADNAQEAAVVKGIAVYGFRNLYEVADFLSQPENYKPVAFDAKAEFDRAPQLISDLADVKGQTHARRALEIAAAGGHNLIFVGPPGSGKTMLAKRLPGILPPLSFTEALEVSQIHSVAGLLKDKGSLIRERPFRSPHHSASGPSLVGGGSFPRPGEISLAHRGVLFLDELTEFKRNVLEFLRQPLEDGYVSISRTRQSVSFPAQFTLVASTNPCPCGYFGDSVQPCTCSARAREQYWAKLSGPLMDRIDLQVAVNRLKPEEMTGRETGENSQTVRERAIAARDRAQHRLKDDPAVRCNAEMRSSHLRRFCQLDDPSRNLLEAAIRKLGLSARAMDRILKVSRTIADLAGEEALKSHHLAEAIQYRTLDRLS
>NC_019689.1|WP_186005353.1|25813_25960_+|hypothetical-protein
MVLPPGSSAIDKGIPISGLTDDFVGKAPNIGAYESGEPRWQAGANLQR
>NC_019689.1|WP_015141835.1|42717_44121_-|ABC-transporter-ATP-binding-protein
MSEIAITLKNVSKCYKRYARPVDRLKEILLPGKSRAEEFWALRDINLEIHQGQTVGIVGRNGSGKSTLLQIIAGTLTPTTGEVNVCGRVSALLELGSGFNPEFTGRQNVFFNGRLLGLSQKEIEDKFDEIAGFADIGDFIDEPVKTYSSGMFVRLAFAVAINVNPEILIVDEALAVGDGVFIHRCMASIKAFQDSGGTILFVSHEMGTVSRLCSQAIWINDGNIVEIGEPDDISRHYQAWMYEQINDYQKKHNEVGNRLVEPIETRDSLENLENIKDRTSQKIKVNPFNEKAYREYHNIERFGTGRAEIISFEVVDNSNKKAGFVYPKDRIKLVVKVLTYDRIQKPIVGIMLYDRLRTAITGFNTYQYQHHLSSLLPEQLLTVEFSLEWPEIQGGNYVLEPAIADGSQENHEMLDWLQFPLNIISGATDLTFGVFRLSSVNISHQITVSQSLRENYLETTRLETRKA
>NC_019689.1|WP_015141836.1|44145_44991_-|ABC-transporter-permease
MRGVVRKAGKLRRWLPFNAQWQAKFDLLRTLVRRDLEARYKGSILGNLWPLLNQLSQLLIYTYVFSIVLKVKLSLRGLPENNLTFGLWLFAGLLPWIAFTGGLTQAAGSVVGQPNLVKKVVFPLALLPLVPILSMFVESYFGLMLLIFFVAVTTHSLHTTLALLPLIWLTQLSLTAGLGYLSAGLTVFLRDIPQTLGVILNIWMYLTPIIYPASAIPQEWRSWVFWLNPMTAIAEVYRDLILVGEVKHWGEWGVASAISAIVFCCGFLVYKKLRPAFADVL
>NC_019689.1|WP_015141837.1|45318_45513_+|DUF2862-domain-containing-protein
MEIGQKVKVYRLRDRVSTDIANKLGKVGTIKEFKMTDGSGVGAIVEFEDNTATWFFEDEIKPVD
>NC_019689.1|WP_015141838.1|45552_46650_+|ArsA-family-ATPase
MSLILTFLGKGGSGRTTMAIAAAKKFASSEKRVLLVGQDPGPTLGLLLGATTSNSPTEITSNLSVVQLFSTIMLEQSWEQIKELEAKYLRSPTLKNVYGQELGILPGMDSALALNAIREYDKSERYDIIVYDGPGDNNTLRMMGIPEVLSWYVRRFRKVLGDSDVGKVLAPFIQPITSAILNVSWSADDLAKEPSDRANNLLEEGKAALANPKRVTAYLVTTADPIAIAAAKYLWGSAQQVGLTVSGVLLNQAEASEAITTEFAPLGVNAIPSRAGDDWQPLIEALPDFQTVSQVPQPMTVDLAARQVRIFLPGFDKKQVKLTQYGPEITIEAGDQRRNIDLPSPLRGQPVRGAKYQSGYLVISF
>NC_019689.1|WP_015141839.1|46683_47691_+|chlorophyll-synthase-ChlG
MSDSSVSNPSDRVKLPTNDDRSAKTRQLLGMKGAASGETSIWKIRLQLMKPITWIPLIWGVICGAASSGEYTWSLENILKIAVCMVLSGPFMTGYTQTVNEYYDREIDAINEPYRPIPSGAIPLSQVIAQIVVLLLGGIGLAYVLDVWAGHEFPTITCIAIGGALLAYIYSAPPLKLKQNGWLGTYALGSSYIALPWWTGHALFGDLNWTIVILTLIYSFAGLGIAVVNDFKSIEGDRQLGLKSLPVMFGVTAAAWICVLTIDLFQAAIAAYLIYIHENLYATILLLLIIPQITFQDMYFLRDPLKNDVKYQASAQPFLVLGMLVTGLALGHAGV
>NC_019689.1|WP_041392520.1|47896_49486_-|alkaline-phosphatase-D-family-protein
MNNPFFNRFLSTQLKRRNLLLGAGVLGGLAIANRSRYLIAQPKYSDYPFSLGVASGEPDSNSVVLWTRLAPNPRRGNTLPSADIPLQWQVATDEKMRRVVAKGVVLATPEWAHSVRVVVEGLESDRWYWYQFRTGNEVSPVGRTRTCPAPTASSKRLSFAFASCQNYEHGYFNAYRHMSEEEIDFVIHLGDYIYEGGGVPRPDNVRSHGSPEPMDLEGYRRHYALYRSDRDLQEAHRLFPFICTWDDHEVDNDYANLESQDFDEIAAFAKRRAAAYQAYYEHLPFRPASRPQGDRMQLYRRFSWGNLALFHILDTRQYRDDQACDENGDGGGQVVECQERLAEARSLLGQPQEQWLLDGLTNSSAHWNIIAQQYLVAQLKQQKDGREGYWSDGWDGYAANRKRILDHIAQQRPSNPIFIGGDIHSFWVSELKSDFQNPASPTVACEFVGTSISSNGVPYDQFASVLPENPHIKFFESRLRGYVKCAVSRQEWRSDLRVVDTVKQQNSKVSTLATFVVEDGNPQVRQLEP
>NC_019689.1|WP_015141841.1|49546_49927_-|photosystem-II-complex-extrinsic-protein-PsbU
MKRLVRILALLTLIVSCLLTLPATPAFAEQPKLNAVDAMLTTEFGKKIDLNNSDIRDFRDLRGFYPNLAGKIIKNSPYNKVEDVLSIPGLSERQKERLQANLDNFIVTPPSKEFNEGGDRINPGVY
>NC_019689.1|WP_015141842.1|50502_51138_+|peroxiredoxin
MALQLGDTVPNFTQDSSEGTISFYEWAGDSWVVLFSHPADYTPVCTTELGAVAKLKPEFDKRNVKILALSVDDAESHRGWIKDINETQNATVNYPIIADPDRKVSNLYGMIHPNSLDNLTVRSVFIIDPNKKLRLTITYPASTGRNFDEILRVIDSLQLTDNYQVATPANWKDGDDCVVVPSIPTEEAKAKFPKGVTEIKSYLRMTPQPNK
>NC_019689.1|WP_015141843.1|51212_52160_-|glycosyltransferase
MTKDNSKVSVIVPIYNGEADLPDLIECLRTQTYPRDRVEYLLVDNNSSDRTGQILATAAAQTSTEKINLQVLREDKIQSSYAARNKAIRIAQGEIIAFTDADCRPQPDWLEKLVIPFANPTVGIVVGELVALPGNTILEQYAERYELMSQKFLVEHPFCSYGQTANIAIRREVFERVGLFRPYLTTGGDADICWRIQKQTDWKLEFAPQAIVRHRHRANLREFKSQWRRYGTSNRYLHELHGVSLMRELTFRESLYRVSRWLLKELPRDSAKLVIGKAKAIDLIRTPIDLIGFQARTTGQKQAKLSEEAKTIEWL
>NC_019689.1|WP_015141844.1|52203_52896_-|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MHFLIPAAGMGKRMGSARNKLLLTLLGKPLLAWTLSAAEASRQISWIGIIGQPDDFADFKAIIAELALAKPVELIKGGETRQESVDNGLQALPSSAERVLIHDGARCLATPELFDRCAEALLTCSGLIAAIPVKDTIKIVDKTNLIKDTPERRYLWAAQTPQGFEVQLLKECHEKGRKLGWEVTDDAALFERCHLPVQIVEGEETNLKVTTPIDLAIAEFILRQRLFSNQ

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Crispr_ID: NC_019689_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_2

626291-626397

Orphan

Consensus_repeat	Method
CTGGCTTTAGCAGAACGCTTGGGCATAGAGTTATGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019689_2

>merge|NC_019689|2|626291-626397|CRISPRCasFinder
CTGGCTTTAGCAGAACGCTTGGGCATAGAGTTATGGACTGTGAAAGCGAAGCCGCTATCCGAGCATGGGCCTGGCTTTAGCAGAACGCTTGGGCATAGAGTTATGGA

>NC_019689|2|2|626291-626397|CRISPRCasFinder
CTGGCTTTAGCAGAACGCTTGGGCATAGAGTTATGGA	CTGTGAAAGCGAAGCCGCTATCCGAGCATGGGC
CTGGCTTTAGCAGAACGCTTGGGCATAGAGTTATGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015142326.1\|625682_625883_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015142336.1\|634851_635190_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_144266173.1\|616122_616557_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224427
NC_019689.1\|WP_015142321.1\|618716_619895_-\|molybdopterin-synthase-adenylyltransferase-MoeB	unknown	unknown	gnl\|CDD\|180967
NC_019689.1\|WP_015142327.1\|626484_627027_-\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|273139
NC_019689.1\|WP_015142332.1\|629615_630326_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015142328.1\|627129_627804_-\|sugar-transferase	unknown	unknown	gnl\|CDD\|376775
NC_019689.1\|WP_015142334.1\|630858_632337_-\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|378817
NC_019689.1\|WP_186005361.1\|615690_615834_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_186005362.1\|620044_620965_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|372616
NC_019689.1\|WP_041392677.1\|628788_628977_-\|DUF2949-domain-containing-protein	unknown	unknown	gnl\|CDD\|371402
NC_019689.1\|WP_015142325.1\|623587_625606_+\|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl\|CDD\|223733
NC_019689.1\|WP_015142337.1\|635291_638096_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NC_019689.1\|WP_041391806.1\|633297_634401_+\|hydrogenase-expression/formation-protein-HypE	unknown	unknown	gnl\|CDD\|273984
NC_019689.1\|WP_186005363.1\|628054_628594_+\|DUF4278-domain-containing-protein	unknown	unknown	gnl\|CDD\|372912
NC_019689.1\|WP_083888324.1\|617563_618214_+\|ubiquinone-biosynthesis-protein	unknown	unknown	gnl\|CDD\|227364
NC_019689.1\|WP_015142323.1\|621077_621533_-\|M67-family-metallopeptidase	unknown	unknown	gnl\|CDD\|163701
NC_019689.1\|WP_051036373.1\|625975_626185_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350221
NC_019689.1\|WP_015142324.1\|621548_623357_-\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NC_019689.1\|WP_015142333.1\|630371_630836_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015142337.1\|635291_638096_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	1.18855e-158
NC_019689.1\|WP_144266173.1\|616122_616557_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224427	COG1510, COG1510, Predicted transcriptional regulators [Transcription].	7.3441e-08
NC_019689.1\|WP_015142321.1\|618716_619895_-\|molybdopterin-synthase-adenylyltransferase-MoeB	gnl\|CDD\|180967	PRK07411, PRK07411, molybdopterin-synthase adenylyltransferase MoeB.	0
NC_019689.1\|WP_015142327.1\|626484_627027_-\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl\|CDD\|273139	TIGR00560, pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis].	1.32051e-44
NC_019689.1\|WP_015142328.1\|627129_627804_-\|sugar-transferase	gnl\|CDD\|376775	pfam02397, Bac_transf, Bacterial sugar transferase. This Pfam family represents a conserved region from a number of different bacterial sugar transferases, involved in diverse biosynthesis pathways.	1.132e-95
NC_019689.1\|WP_015142334.1\|630858_632337_-\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|378817	pfam12128, DUF3584, Protein of unknown function (DUF3584). This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.	0.00102918
NC_019689.1\|WP_186005363.1\|628054_628594_+\|DUF4278-domain-containing-protein	gnl\|CDD\|372912	pfam14105, DUF4278, Domain of unknown function (DUF4278). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 58 and 136 amino acids in length. There is a single completely conserved residue R that may be functionally important.	6.86832e-10
NC_019689.1\|WP_186005362.1\|620044_620965_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.11679e-22
NC_019689.1\|WP_041392677.1\|628788_628977_-\|DUF2949-domain-containing-protein	gnl\|CDD\|371402	pfam11165, DUF2949, Protein of unknown function (DUF2949). This family of proteins with unknown function appear to be restricted to Cyanobacteria.	1.74836e-26
NC_019689.1\|WP_015142325.1\|623587_625606_+\|AarF/ABC1/UbiB-kinase-family-protein	gnl\|CDD\|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	0
NC_019689.1\|WP_041391806.1\|633297_634401_+\|hydrogenase-expression/formation-protein-HypE	gnl\|CDD\|273984	TIGR02124, Hydrogenase_expression/formation_protein_HypE, hydrogenase expression/formation protein HypE. This family contains HypE (or HupE), a protein required for expression of catalytically active hydrogenase in many systems. It appears to be an accessory protein involved in maturation rather than a regulatory protein involved in expression. HypE shows considerable homology to the thiamine-monophosphate kinase ThiL (TIGR01379) and other enzymes.	3.13141e-174
NC_019689.1\|WP_083888324.1\|617563_618214_+\|ubiquinone-biosynthesis-protein	gnl\|CDD\|227364	COG5031, COQ4, Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism].	9.26348e-67
NC_019689.1\|WP_015142323.1\|621077_621533_-\|M67-family-metallopeptidase	gnl\|CDD\|163701	cd08070, MPN_like, Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding). This family contains archaeal and bacterial MPN (also known as Mov34, PAD-1, JAMM, JAB, MPN+)-like domains. These domains contain the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, EXnHS/THX7SXXD, which is involved in zinc ion coordination and provides the active site for isopeptidase activity for the release of ubiquitin from ubiquitinated proteins (thus having deubiquitinating (DUB) activity) that are tagged for degradation. The JAMM proteins likely hydrolyze ubiquitin conjugates in a manner similar to thermolysin, in which the zinc-polarized aqua ligand serves as the nucleophile, compared with the classical DUBs that do so with a cysteine residue in the active site.	1.7337e-46
NC_019689.1\|WP_051036373.1\|625975_626185_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350221	cd09873, PIN_Pae0151-like, VapC-like PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Pyrobaculum aerophilum proteins, Pae0151 and Pae2754, and homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.98654e-11
NC_019689.1\|WP_015142324.1\|621548_623357_-\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	0

>NC_019689.1|WP_051036373.1|625975_626185_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MICVDTSFIIRLLTSQDTDSPYDQRWNQWQASNATIVAPTLIMYEVSNGLYQYSRAGQITIEEIEQLVE
>NC_019689.1|WP_015142326.1|625682_625883_+|hypothetical-protein
MNTKLVNSLVQIIQSLTPEEQALLEERLQSKKNWQQEYQKLLEVRAKIFARRKGKPLEPTPEEIIH
>NC_019689.1|WP_015142325.1|623587_625606_+|AarF/ABC1/UbiB-kinase-family-protein
MSQTTLSPTLQSLEIVTIEDRPLHIPEKHRENLGPVNDKDPESWRYHPDVINTYYRSRPFQVLGRLIEIVLPLIFFAFRLWTDKISGRLERNQQKRAIQLREMLTNLGPTYIKVGQALSTRPDLVPPAYLQELTTLQDQLPSFPNEIAYRFIEEELGAKPDEIYAELSEKPIAAASLGQVYQGRLKTGEKVAVKVQRPDLARRITLDIYIMRSLAGWAQKNLKQIRSDLVAITDELASRIFEEMNYCHEGKNAEKFAELYGHLPEIYVPKIYWEYTGRRVLTMEWIDGTKLTNIKAIEAQGINAAHLVEVGVNCSLRQLLEHGFFHADPHPGNLLATTDGKLAYIDFGMMSNIKPYQRYGLIEAVVHLVNRDFEALAYDYVKLDFLKPDTDLSPIIPALAKVFGNALGASVAELNFKSITDQMSEMMYEFPFRVPAYYALIIRSMVTLEGIAIGIDPNFKVLSKAYPYIAKRLLTDPSPQLRSSLRDLLFKEGSFRWNRLENLLRNAKNSPDYDFSSALNQAVDFLFSDRGTFIREKLVDELVNAIDIFGRRTLFNWSAAVREQVGVAVQETPPELRKNSQTIEHLKNILRILQETPGFDPMHLLTMLTQLVTKPETQQMGQQIVEKLVQKAIARFIRSLLLEQPQDPQNGTYNYSDSQKALPSAAFRSWEW
>NC_019689.1|WP_015142324.1|621548_623357_-|DNA-repair-protein-RecN
MLSCLRIKNFALIDQLELEFSRGLTVLTGETGAGKSIILDAIDIALGGKANNRLIRQGAQQAIVEATFRVNADVRAWLQELEIDLLEDESVVCSRELTVVGDSLRSRSRINGILANRQLMAKLRDRLVEITAQGQTVQLMDSSMQRELLDLYGGTPLWQQREIVASTYNIAQAARSALEKRRQSEQQRLQRLDLLNYQVKELESANLSDPQELEQLEQERDRLAHVVDLQQLSYQANQILYQSDSEQPAVADLLGQAESILMDMTKYDEGIEPILEIIRMALNEVIEAGHQINTYGDGLEADPERLAEVEERILFLKRLCRKYGASLAEVISYYQQLQQELAELTDSDRSVEKLEAEDRIARENLNQACQELTKLRQQVATKLEKQLTEELKPLAMDKVVFVCQIDPCPPTATGSDRVVFYFSPNAGEKIQPLASTASGGEMSRFLLALKACFSDSEKQSGTLIFDEIDAGVSGKVAQAIAEKLHHLSQKHQVLCVTHQPLVAAMADSHFRVDKQIIEEFPSDIQDNNGQSHLPEIRTVVRVSSLENLQMRREELAQLTGGHSAEDAIAFAESLLAKAQAAKGLSVGESHAEAQRRRGRRKR
>NC_019689.1|WP_015142323.1|621077_621533_-|M67-family-metallopeptidase
MIRATLEQIQQIRAHAENTYPEECCGLLIGKIEGENKILIEVIATENSWDAEAAEFLSVEAGSKRNRFSIAPEVLLRVQKETRDRNLSIIGIYHSHPDHPAIPSEFDRAIAWQQYSYMIISLSQGRAVEIRSWFLDENRQFKPENNFSNQL
>NC_019689.1|WP_186005362.1|620044_620965_-|methyltransferase-domain-containing-protein
MSMPIDWLKGKPTPYGEIYWCEESQYGLVMPRPDRESVRSFYDLKAYYTHGSNHVTESEKNTFLDRLRVNIAWKFDRGTEITANFIDRCLAGKISRICEIGCGNGELIQQLKEIGHKVCGIEPDEKALAFLKDLDVYPGTAEEIPTAIMSRSFDLVIIKHVLEHCLDPLVALRNAYQLLRSGGMLICEVPNNCALQLSYDGVTWPFLDIPRHLNFFTPTSLRTICEKSGFKTQSLFFRGFTRQFSNSWINTQASIWDRLRDARAQTAARPLPKRISQIRVWKHLFFSLLASAEKKYDSVGIIAIRP
>NC_019689.1|WP_015142321.1|618716_619895_-|molybdopterin-synthase-adenylyltransferase-MoeB
MLNPNLEEIELSKEEYQRYSRHIILPEVGLEGQKRLKAASVLCVGTGGLGSPLLLYLAAAGIGRIGIVDFDVVDSSNLQRQIIHGTSWVGKSKIQSAKDRILEINPYCQVDLYEVRLTSENALDILKPYDVIIDGTDNFPTRYLTNDACVILNKPNVYGSIFRFDGQATVFNYQDGPNYRDLYEEPPPPGMVPSCAEGGVLGVLPGVIGTIQATEAIKIILGVPPENTLSGRLLVYNAMNMTFRELRLRRNPNLAPIEKLIDYEQFCGIPQAKAQEAQQQMEISEMTVQELKALIDSGADGYVLIDVRNPNEYEIAKIPGSILIPLPEIENGSGIEKVKELVNGHRLIAHCKMGGRSAKALGILKKAGIEGINVKGGITAWSKEIDPSVPQY
>NC_019689.1|WP_083888324.1|617563_618214_+|ubiquinone-biosynthesis-protein
MLTGEESLDSVGELTAALLETPAFELAAKSLKADPACAALIRDRYIPPAHNLDELLHYPQDSLGYIYAYTMKDKGFDPDLYSHMAADSDASYVELRLSQTHDIWHIIAGFDTSCAGEIGLQAFHLSQFPYPLAAMLIANSLISSTLLAPKELPKLVQEIDRGLQMGKQAKSLFAQKWEQDWKKPLIQWQRELNIRISSAIAFNPKIGNSSSKSKKS
>NC_019689.1|WP_144266173.1|616122_616557_+|MarR-family-transcriptional-regulator
MEGLPRMAGQIIGHLLFSRSPLVSSAELAEALQVTKGVISTTSRLLIQVELIERVKLMGDRRDYFRLKKRPWFHSFKQELYLISAYRQMAQRGLQAIEDYESERKEALQEMFELYSFLEREFPALIDRWEQEWATKQSKNSQKK
>NC_019689.1|WP_186005361.1|615690_615834_+|hypothetical-protein
MKGYEQARACNYELPQSGLTTELESWLDKAIASQVGMSQYHLARLLF
>NC_019689.1|WP_015142327.1|626484_627027_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MNLPNWITFSRLLGLPFIFYFLQVPTPQNRWIGLAIFLLAASTDWVDGYLARQLNQITELGKFLDPLVDKLLVLATLLVLIELEKIPAWGVFLILGRELAIAGWRVNPNLTGESSIKGANFWGKLKTVSQIIAVALLIAPLSEAWTIPSLVAFWISVLLTLISGVIYLLPQKSSYSSSAG
>NC_019689.1|WP_015142328.1|627129_627804_-|sugar-transferase
MHSSVSSLIRTSYLEQPIAEQAVHPSVYSKRKRLIDIAGALVGLGITAILTVPIAIAMQVTSPGPIFYSQVRCGLRGKPFRIWKFRSMVVDADQKKHLVQNQAQGHIFKNENDPRITRVGRFLRRTSLDELPQFWNVLMGEMSLVGTRPPTPDEVQKYDSHHFERLKVKPGMTGEWQAKGRSNVKDFEDIVRMDIDYQRQWSILYDLYLIFRTIAVVFAGRGAY
>NC_019689.1|WP_186005363.1|628054_628594_+|DUF4278-domain-containing-protein
MNSLNSQSSDRFIYSLKHFYFGIEVAIMRWLFLIPLTTGLISGYISQKSADEIAYLTGALTIMSLLASLVMAPWQVQLLILVLVFIIVRQFWLKLEFESQLETEQQEKADVFRVTSTPNEVERKTIRKYRGVTYEPPASTSSVTEVEIEGKYRGATCKVHYLQQTSDPLHKRDLDLKEQ
>NC_019689.1|WP_041392677.1|628788_628977_-|DUF2949-domain-containing-protein
MNVTHSHLLRFLQEELALPADSLAIAQRSAEQDRGPLPMILWQYGLITLEELDRIYDWLEEI
>NC_019689.1|WP_015142332.1|629615_630326_-|hypothetical-protein
MNRRRHLKPARPTQNLDSFLDILTNTVGVLMFISLFISLISIQASTTIRTPLVSKSEKKAHYFEVRGKRVTYLDDAAIDRQLTILVSSLPRCDRPDIPQNLDSDFYQYYLSDIEEYEVCTNKVFERLKGFRAQTKNYNVRLVGVDAIMYEPTGENSGETIKEIAKSDSEFGTVLKKLNPQTDYLAFIVRPDSFSAFRAARQQAWEKGFEIGWEPQSVEKSIVFNISGSGGRAVGVQ
>NC_019689.1|WP_015142333.1|630371_630836_-|hypothetical-protein
MSRRSHSHQSIETELFPFLSVLACTIGTLILLIIVLTMQLFTSQREVTIVAKNETNEIGKNRSKTPHYIECRRDGVIIHPSQKFVAQENLEEPNSALINLINEVKAKRDREYVIVALRPDGLEVFQKVRDLIEKEEIDIGYEPIEKDWKLKINN
>NC_019689.1|WP_015142334.1|630858_632337_-|MotA/TolQ/ExbB-proton-channel-family-protein
MKKASNNTSGDFERKKLDVDLLTVSLIALLITIAIYLIVLPFRTSFIGILLYDRGLTQPFAIYFACIVATLNFLKFIKLQKELKALKNFWIPETIQLGDPNAKDIVQVQKTLARDGRLIAIRCSRVIATYIQSGNRKAASELALDDSSFYVSASESSYTFPRILIWAIPLLGFIGTVFGISEAVNGFSGLLEKAADVEQIKEGIGTVTTGLAIAFDTTLLALFLSVLVMIPLVALERLESRLLLGIDVYINDHLLPRFKDKTDLDEQAIDRAIDKAVKEHLPEPEALIKPAHEYARQAVATLAQNFVSEVSKLQEVHSKLIEQIGQVNRMALEDRYAYTTALEKQKNTNQNLIAEIRSIVEAIEGNNVSVLEKQKEIHQNLLGEIRAIIGTVKTTHAEMSTSFVSQTQQISARLERASQMLGTRIADLEKAAMQLSEINRLTQSLERVLASLEQARYLNQALIEIRESLIQLKPALEKMSKPRIITFVDSEE
>NC_019689.1|WP_041391806.1|633297_634401_+|hydrogenase-expression/formation-protein-HypE
MTHNPTNPTHHPLFQKVERVRRRRAKVRDTNITLAHGSGGKAMRDLIDDIFVGSFDNPLLAELEDQARIGLAELLAAGDRLAFTTDSYVVDPIFFPGGDIGSLAVHGTVNDLAVSGAKPFYLSCSMILEEGLPVDALRQVARSMKAAADAAGVKIVTGDTKVVHRGSADKIFINTTGIGVIRPEVSISARNLQPGDKIIVNGYLGDHGAAILIARGELALSSAIESDSQPLNSLVDAILDVCPEVRAMRDATRGGLATVLNEFALSSEVGIRLYESSMPVREEVQGICELLGLDPLYLANEGKLAVVVPGDRAQTILAAMRAHPAAGKASIIGEVIDSPPGVVLMQTLFGTERIVDMLVGDQLPRIC
>NC_019689.1|WP_015142336.1|634851_635190_+|hypothetical-protein
MKTVLHTLFFIGILELTLSSPAKSRISSVAQASSTQYTFEDYRKECLQRATREKLPQDVAEDLCNCTINRFRSQYTLEEFRSLVKKSKNNTAAAETLTAVGESCFEEVMYEE
>NC_019689.1|WP_015142337.1|635291_638096_+|efflux-RND-transporter-permease-subunit
MKQSSRKLSLRERLNISRLAIQFPRITIAFWIAVSVAGIFAFSSLKYALFPDITFPVVIVTAQAPIETTLDTENQLTKPIEKPLQSLERLDELSSSTYPGQTVVKVLFVPGTKLESATEKVKEALTQVSLPPKTTFEVVPIDLNESSAISYAIKGENKSLSQLVQIAKAQIVPQIKQLPGVLKVNLLGDIRSNSPTRVRFNGQDAIALQIIKRSQANTLDVVTQVEQAVQQLQAKFSDLQLVLAETQADYIREATQATIDALIGAIVLAILVIFPFLRNFKATLITALAIPISLLGTFIVMAIAGFNLETMTLLALALVIGIVVDDAIVDVENIARHVEKGENSREAAIKGTGEIGLAVTASTLTIAAVFVPVALMRNAVGEFFKPFGLTVSAAVVFSLLVARTLSPVLAVYWLKPRNNRNESLQRLEARNNSQGAISNAIANNYYRNLLGWSLHNRKIVVAIAILSFASGIALIPLIPKGFIPKLDRGEFNIAYTAPLPKLAGQFQSGTPNTNPKSAERSRRTPLEVNSSTTATKTQNPKSNNGAFAWMENLAKSPERLLLRKTIKVGQQLEEVVLTFSEVESVFTTAGLRGDPTKGKLYIRLKRDPRSRSVPEGFSASAENRQLTTAEVQAKIRAALPTLKGVSASVEDIPFVQTEAEKPIQIAILGKNLNLLRKTAQQLETRVEKLPGLVDVALSGQEKQGENALEVERLNGQRVVYLSANLAQQQGLEDAAWQIEQIAQSIFPKGITLKRWGSSAHSSDVLSSFGSTMTLSIFLMLSVLLLLFGRLLEPIAVGLSLPLSIVGAMLGLLATQSDFGVISLLGLIFLLGLLDKNALLLMDYTNQLRESGLSREEALVETGAVRLRPIIMTTASTILGMLPIALGWGAGAELRQPMAVVIIGGLITSSLLSLIVVPVLYTLLEDGWTKMFGKR

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Crispr_ID: NC_019689_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_3

1226682-1229689

Orphan

I-D,II-B

Consensus_repeat	Method
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	PILER-CR
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CRISPRCasFinder
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CRT

41 spacers

The CRISPR arrays of NC_019689_3

>merge|NC_019689|3|1226682-1229689|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTCTTCCTGCGAATCCTCCTATGATATTAAAAGATTTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATGACCTGCCAAGTGTTTCCAAGTATTTTTCTTCGCTCTGTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATAGGGGATTGATGAGGTACTGAGTAAGCTTAAGGAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATATCATGATTCCGTAGGGTATGTTTGCTTAGTTTTCGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTCGCAGCCGTGGATTAAATCGGGAGATGTCCATAAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTCGGGTGGGCCAAAGAATATTCGAGAATGGAGGCCTGCTTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATGGGCGATTCCTGCGAGTCCTTTTGCTTCTTGGGCTTCTCGGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATCCAGGCTTGTTTGTCGTTGTACAAGTCAGGTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATATGAAGAAATGAAACGCCTGATCAGGCAAATCGACCAAACGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATGTACAAACGTTCGTCCGCAACGGGTTACACCTTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATCTTTGATGAAAGCTATTCTAGTGAAACTGGAATGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTTTTTTCGGGAAGATTTACTACGAAAATCTTCCCGGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAACCAAATCGGCTATTTGACGCTCTGATTTTTTGTCCGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTGATCTAACTAGTGCTAGAGGTGCATTGAGAACGGGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTCCCACATCCGCCTCAAGAAGGAGGTGATCGGTGAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATATTGGAGTCGCCGATCGTTACTTTGTTTTTTTCGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTTAGGAAATATCTAAAAAAATGTCCCTCGAACGCATCCTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTTAGGAAATATCTAAAAAAATGTCCCTCGAACGCATCCTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATCTTACCAAGCTTTTGGCTATACGGGGGTTTGGGAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTTATAGGTTTTATTTTTATTAAAATTCTTCCTTAAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATCGAGACGAAAATATTCCTGTCAAAAATCAAGCCGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTCTTACACGGTAGCGTCCAACCAAGCGCGGCTTATCCGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATGGTAGGAAGATTTTCGTAGAAATCTTTCTAGCCGAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATCGGGAGAGTTACTGGAATGGAAAAAAGCGCAGTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATGCGAAAGCCTCTCCCAATCGGCATCCTGTCAGAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATCTAGAAGCAAACGGGATGCCTTGGACTATAAAATTTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATCTAGAAGCAAACGGGATGCCTTGGACTATAAAATTTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTTGGCAGGAATCAATGTTCCCACCAGCCAAAAGGGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTCAACAGCTCGACGAACAGAAAAAAGAATTTGAGCGAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATCGGGAAGGATGCTGAAGTGGATGAAGAAACAAGGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTTTTGGAATCCAATGCGGAGGATATTATGGAAATCTGGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATATAATGGGTGAGGCTCGTTCATGTAGAAGGGCACGAAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATAATTCTTTTTCGACATTTCCCTTGTTTAAAAAATAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTCTATTAGCTTAAGGTGGGTATACGAGCAATTCTCGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTACATTAGTACTATCCGAGCGCACGTAACTATTAAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAGATAAATGGTTAGCCCGGCGATACTCGTACCCAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATGAATCGCTAGTTACGCTTGCTCCAACGTTAATGTCAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTGCTGAAGTTCCCAAATGGCTGCTCGATATTGAAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATCCGTAATTAGGATGGGGAGGCGAGGGGTTTGCTTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTTGAAAAATCATTTCAATTTCCTCAAAAATTAATAGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAATTTGGTTCCCCTTCCCCGGTTGTTGGTTAAAAGCTTTTATCCTGTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT

>NC_019689|3|1|1226682-1229688|PILER-CR
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTCTTCCTGCGAATCCTCCTATGATATTAAAAGATTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TGACCTGCCAAGTGTTTCCAAGTATTTTTCTTCGCTCTGT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TAGGGGATTGATGAGGTACTGAGTAAGCTTAAGGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TATCATGATTCCGTAGGGTATGTTTGCTTAGTTTTC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTCGCAGCCGTGGATTAAATCGGGAGATGTCCATAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTCGGGTGGGCCAAAGAATATTCGAGAATGGAGGCCTGCTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TGGGCGATTCCTGCGAGTCCTTTTGCTTCTTGGGCTTCTCG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TCCAGGCTTGTTTGTCGTTGTACAAGTCAGGT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TATGAAGAAATGAAACGCCTGATCAGGCAAATCGACCAAAC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TGTACAAACGTTCGTCCGCAACGGGTTACACCTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TCTTTGATGAAAGCTATTCTAGTGAAACTGGAAT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTTTTTTCGGGAAGATTTACTACGAAAATCTTCCCG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	CCAAATCGGCTATTTGACGCTCTGATTTTTTGTCC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTGATCTAACTAGTGCTAGAGGTGCATTGAGAACGG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTCCCACATCCGCCTCAAGAAGGAGGTGATCGGTGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TATTGGAGTCGCCGATCGTTACTTTGTTTTTTTC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTTAGGAAATATCTAAAAAAATGTCCCTCGAACGCATCCT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTTAGGAAATATCTAAAAAAATGTCCCTCGAACGCATCCT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TCTTACCAAGCTTTTGGCTATACGGGGGTTTGGGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTTATAGGTTTTATTTTTATTAAAATTCTTCCTTAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TCGAGACGAAAATATTCCTGTCAAAAATCAAGCC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTCTTACACGGTAGCGTCCAACCAAGCGCGGCTTATCC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TGGTAGGAAGATTTTCGTAGAAATCTTTCTAGCCGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TCGGGAGAGTTACTGGAATGGAAAAAAGCGCAGT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TGCGAAAGCCTCTCCCAATCGGCATCCTGTCAGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TCTAGAAGCAAACGGGATGCCTTGGACTATAAAATTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TCTAGAAGCAAACGGGATGCCTTGGACTATAAAATTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTTGGCAGGAATCAATGTTCCCACCAGCCAAAAGG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTCAACAGCTCGACGAACAGAAAAAAGAATTTGAGCGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TCGGGAAGGATGCTGAAGTGGATGAAGAAACAAG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTTTTGGAATCCAATGCGGAGGATATTATGGAAATCTG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TATAATGGGTGAGGCTCGTTCATGTAGAAGGGCACGAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TAATTCTTTTTCGACATTTCCCTTGTTTAAAAAATA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTCTATTAGCTTAAGGTGGGTATACGAGCAATTCTC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTACATTAGTACTATCCGAGCGCACGTAACTATTAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	GATAAATGGTTAGCCCGGCGATACTCGTACCCA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TGAATCGCTAGTTACGCTTGCTCCAACGTTAATGTCA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTGCTGAAGTTCCCAAATGGCTGCTCGATATTGAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TCCGTAATTAGGATGGGGAGGCGAGGGGTTTGCTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTTGAAAAATCATTTCAATTTCCTCAAAAATTAATA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA	TTTGGTTCCCCTTCCCCGGTTGTTGGTTAAAAGCTTTTATCCT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAA

>NC_019689|3|3|1226682-1229689|CRISPRCasFinder
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCTTCCTGCGAATCCTCCTATGATATTAAAAGATTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GACCTGCCAAGTGTTTCCAAGTATTTTTCTTCGCTCTGT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	AGGGGATTGATGAGGTACTGAGTAAGCTTAAGGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	ATCATGATTCCGTAGGGTATGTTTGCTTAGTTTTC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCGCAGCCGTGGATTAAATCGGGAGATGTCCATAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCGGGTGGGCCAAAGAATATTCGAGAATGGAGGCCTGCTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GGGCGATTCCTGCGAGTCCTTTTGCTTCTTGGGCTTCTCG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CCAGGCTTGTTTGTCGTTGTACAAGTCAGGT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	ATGAAGAAATGAAACGCCTGATCAGGCAAATCGACCAAAC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GTACAAACGTTCGTCCGCAACGGGTTACACCTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CTTTGATGAAAGCTATTCTAGTGAAACTGGAAT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTTTTTCGGGAAGATTTACTACGAAAATCTTCCCG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAC	CAAATCGGCTATTTGACGCTCTGATTTTTTGTCC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TGATCTAACTAGTGCTAGAGGTGCATTGAGAACGG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCCCACATCCGCCTCAAGAAGGAGGTGATCGGTGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	ATTGGAGTCGCCGATCGTTACTTTGTTTTTTTC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTAGGAAATATCTAAAAAAATGTCCCTCGAACGCATCCT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTAGGAAATATCTAAAAAAATGTCCCTCGAACGCATCCT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CTTACCAAGCTTTTGGCTATACGGGGGTTTGGGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTATAGGTTTTATTTTTATTAAAATTCTTCCTTAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CGAGACGAAAATATTCCTGTCAAAAATCAAGCC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCTTACACGGTAGCGTCCAACCAAGCGCGGCTTATCC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GGTAGGAAGATTTTCGTAGAAATCTTTCTAGCCGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CGGGAGAGTTACTGGAATGGAAAAAAGCGCAGT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GCGAAAGCCTCTCCCAATCGGCATCCTGTCAGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CTAGAAGCAAACGGGATGCCTTGGACTATAAAATTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CTAGAAGCAAACGGGATGCCTTGGACTATAAAATTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTGGCAGGAATCAATGTTCCCACCAGCCAAAAGG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCAACAGCTCGACGAACAGAAAAAAGAATTTGAGCGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CGGGAAGGATGCTGAAGTGGATGAAGAAACAAG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTTTGGAATCCAATGCGGAGGATATTATGGAAATCTG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	ATAATGGGTGAGGCTCGTTCATGTAGAAGGGCACGAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	AATTCTTTTTCGACATTTCCCTTGTTTAAAAAATA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCTATTAGCTTAAGGTGGGTATACGAGCAATTCTC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TACATTAGTACTATCCGAGCGCACGTAACTATTAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAG	ATAAATGGTTAGCCCGGCGATACTCGTACCCA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GAATCGCTAGTTACGCTTGCTCCAACGTTAATGTCA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TGCTGAAGTTCCCAAATGGCTGCTCGATATTGAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CCGTAATTAGGATGGGGAGGCGAGGGGTTTGCTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTGAAAAATCATTTCAATTTCCTCAAAAATTAATA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTGGTTCCCCTTCCCCGGTTGTTGGTTAAAAGCTTTTATCCT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT

>NC_019689|3|2|1226682-1229689|CRT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCTTCCTGCGAATCCTCCTATGATATTAAAAGATTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GACCTGCCAAGTGTTTCCAAGTATTTTTCTTCGCTCTGT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	AGGGGATTGATGAGGTACTGAGTAAGCTTAAGGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	ATCATGATTCCGTAGGGTATGTTTGCTTAGTTTTC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCGCAGCCGTGGATTAAATCGGGAGATGTCCATAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCGGGTGGGCCAAAGAATATTCGAGAATGGAGGCCTGCTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GGGCGATTCCTGCGAGTCCTTTTGCTTCTTGGGCTTCTCG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CCAGGCTTGTTTGTCGTTGTACAAGTCAGGT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	ATGAAGAAATGAAACGCCTGATCAGGCAAATCGACCAAAC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GTACAAACGTTCGTCCGCAACGGGTTACACCTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CTTTGATGAAAGCTATTCTAGTGAAACTGGAAT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTTTTTCGGGAAGATTTACTACGAAAATCTTCCCG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAC	CAAATCGGCTATTTGACGCTCTGATTTTTTGTCC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TGATCTAACTAGTGCTAGAGGTGCATTGAGAACGG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCCCACATCCGCCTCAAGAAGGAGGTGATCGGTGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	ATTGGAGTCGCCGATCGTTACTTTGTTTTTTTC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTAGGAAATATCTAAAAAAATGTCCCTCGAACGCATCCT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTAGGAAATATCTAAAAAAATGTCCCTCGAACGCATCCT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CTTACCAAGCTTTTGGCTATACGGGGGTTTGGGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTATAGGTTTTATTTTTATTAAAATTCTTCCTTAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CGAGACGAAAATATTCCTGTCAAAAATCAAGCC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCTTACACGGTAGCGTCCAACCAAGCGCGGCTTATCC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GGTAGGAAGATTTTCGTAGAAATCTTTCTAGCCGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CGGGAGAGTTACTGGAATGGAAAAAAGCGCAGT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GCGAAAGCCTCTCCCAATCGGCATCCTGTCAGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CTAGAAGCAAACGGGATGCCTTGGACTATAAAATTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CTAGAAGCAAACGGGATGCCTTGGACTATAAAATTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTGGCAGGAATCAATGTTCCCACCAGCCAAAAGG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCAACAGCTCGACGAACAGAAAAAAGAATTTGAGCGA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CGGGAAGGATGCTGAAGTGGATGAAGAAACAAG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTTTGGAATCCAATGCGGAGGATATTATGGAAATCTG
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	ATAATGGGTGAGGCTCGTTCATGTAGAAGGGCACGAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	AATTCTTTTTCGACATTTCCCTTGTTTAAAAAATA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TCTATTAGCTTAAGGTGGGTATACGAGCAATTCTC
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TACATTAGTACTATCCGAGCGCACGTAACTATTAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAG	ATAAATGGTTAGCCCGGCGATACTCGTACCCA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	GAATCGCTAGTTACGCTTGCTCCAACGTTAATGTCA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TGCTGAAGTTCCCAAATGGCTGCTCGATATTGAA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	CCGTAATTAGGATGGGGAGGCGAGGGGTTTGCTT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTGAAAAATCATTTCAATTTCCTCAAAAATTAATA
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT	TTGGTTCCCCTTCCCCGGTTGTTGGTTAAAAGCTTTTATCCT
GTTTCAATCCCTAATAGGGATTAAGAATGTTTGGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015142880.1\|1239098_1240070_+\|glutathione-synthase	unknown	unknown	gnl\|CDD\|235371
NC_019689.1\|WP_015142879.1\|1238618_1238888_+\|glutaredoxin-3	unknown	unknown	gnl\|CDD\|274017
NC_019689.1\|WP_015142877.1\|1237021_1237645_-\|TenA-family-protein	unknown	unknown	gnl\|CDD\|381703
NC_019689.1\|WP_015142868.1\|1222948_1223683_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NC_019689.1\|WP_015142870.1\|1224353_1225706_-\|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236426
NC_019689.1\|WP_041392835.1\|1223679_1224246_-\|nicotinate-nucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
NC_019689.1\|WP_015142875.1\|1234364_1236020_+\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NC_019689.1\|WP_015142867.1\|1220841_1222536_-\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NC_019689.1\|WP_015142873.1\|1229969_1232438_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NC_019689.1\|WP_015142860.1\|1210134_1210905_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_051036386.1\|1232823_1233054_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223131
NC_019689.1\|WP_015142864.1\|1213143_1213404_-\|MoaD/ThiS-family-protein	unknown	unknown	gnl\|CDD\|340452
NC_019689.1\|WP_015142874.1\|1233364_1234243_-\|4-hydroxybenzoate-solanesyltransferase	unknown	unknown	gnl\|CDD\|237240
NC_019689.1\|WP_015142878.1\|1237658_1238435_-\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NC_019689.1\|WP_015142861.1\|1210954_1211320_-\|Mo-dependent-nitrogenase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|369150
NC_019689.1\|WP_015142871.1\|1226350_1226641_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_041391877.1\|1233095_1233281_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223131
NC_019689.1\|WP_015142876.1\|1236202_1236940_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187594
NC_019689.1\|WP_083888329.1\|1218764_1219655_+\|glycine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|236473
NC_019689.1\|WP_041392833.1\|1211916_1213080_-\|GuaB3-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl\|CDD\|236322

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015142880.1\|1239098_1240070_+\|glutathione-synthase	gnl\|CDD\|235371	PRK05246, PRK05246, glutathione synthetase; Provisional.	0
NC_019689.1\|WP_015142879.1\|1238618_1238888_+\|glutaredoxin-3	gnl\|CDD\|274017	TIGR02181, GRX_bact, Glutaredoxin, GrxC family. Glutaredoxins are thioltransferases (disulfide reductases) which utilize glutathione and NADPH as cofactors. Oxidized glutathione is regenerated by glutathione reductase. Together these components compose the glutathione system. Glutaredoxins utilize the CXXC motif common to thioredoxins and are involved in multiple cellular processes including protection from redox stress, reduction of critical enzymes such as ribonucleotide reductase and the generation of reduced sulfur for iron sulfur cluster formation. Glutaredoxins are capable of reduction of mixed disulfides of glutathione as well as the formation of glutathione mixed disulfides. This family of glutaredoxins includes the E. coli protein GrxC (Grx3) which appears to have a secondary role in reducing ribonucleotide reductase (in the absence of GrxA) possibly indicating a role in the reduction of other protein disulfides. [Energy metabolism, Electron transport].	1.18063e-44
NC_019689.1\|WP_015142877.1\|1237021_1237645_-\|TenA-family-protein	gnl\|CDD\|381703	cd19368, TenA_C_AtTH2-like, TenA_C family similar to the N-terminal TenA_C domain of Arabidopsis thaliana thiamine requiring 2. This TenA family belongs to the TenA_C class as it has a conserved active site Cys residue; the double Glu residues identified in the active site of TenA_E from the archaeon Pyrococcus furiosus is conserved in this family. TenA_C proteins (EC 3.5.99.2) catalyze the hydrolysis of the thiamin breakdown product 4-amino-5-amino-methyl-2-methylpyrimidine (amino-HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in a thiamin salvage pathway. Arabidopsis thaliana TH2 is an orphan enzyme thiamin monophosphate phosphatase which has a haloacid dehalogenase (HAD) family domain fused to its TenA_C domain, it's TenA_C domain has thiamin salvage hydrolase activity against amino-HMP. This family includes mostly uncharacterized single-domain TenA_C- like proteins; some however have additional domains such as a HAD family domain or a kinase domain It has also been suggested that TenA proteins act as transcriptional regulators based on changes in gene-expression patterns when TenA is overexpressed in Bacillus subtilis, however this effect may be indirect.	3.52245e-90
NC_019689.1\|WP_015142868.1\|1222948_1223683_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	3.89281e-22
NC_019689.1\|WP_015142870.1\|1224353_1225706_-\|nicotinate-phosphoribosyltransferase	gnl\|CDD\|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NC_019689.1\|WP_041392835.1\|1223679_1224246_-\|nicotinate-nucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	3.28193e-59
NC_019689.1\|WP_015142875.1\|1234364_1236020_+\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	3.03835e-167
NC_019689.1\|WP_015142867.1\|1220841_1222536_-\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NC_019689.1\|WP_015142873.1\|1229969_1232438_-\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	1.7914e-69
NC_019689.1\|WP_051036386.1\|1232823_1233054_+\|hypothetical-protein	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.24398e-07
NC_019689.1\|WP_015142864.1\|1213143_1213404_-\|MoaD/ThiS-family-protein	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	9.50782e-25
NC_019689.1\|WP_015142874.1\|1233364_1234243_-\|4-hydroxybenzoate-solanesyltransferase	gnl\|CDD\|237240	PRK12870, ubiA, 4-hydroxybenzoate octaprenyltransferase.	7.87731e-162
NC_019689.1\|WP_015142878.1\|1237658_1238435_-\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	9.20734e-21
NC_019689.1\|WP_015142861.1\|1210954_1211320_-\|Mo-dependent-nitrogenase-C-terminal-domain-containing-protein	gnl\|CDD\|369150	pfam06967, Mo-nitro_C, Mo-dependent nitrogenase C-terminus. This family represents the C-terminus (approximately 80 residues) of a number of bacterial Mo-dependent nitrogenases. These are involved in nitrogen fixation in cyanobacteria. Note that many family members are hypothetical proteins.	5.92179e-56
NC_019689.1\|WP_041391877.1\|1233095_1233281_+\|hypothetical-protein	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	5.09977e-07
NC_019689.1\|WP_015142876.1\|1236202_1236940_+\|SDR-family-oxidoreductase	gnl\|CDD\|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.79925e-102
NC_019689.1\|WP_083888329.1\|1218764_1219655_+\|glycine--tRNA-ligase-subunit-alpha	gnl\|CDD\|236473	PRK09348, glyQ, glycyl-tRNA synthetase subunit alpha; Validated.	0
NC_019689.1\|WP_041392833.1\|1211916_1213080_-\|GuaB3-family-IMP-dehydrogenase-related-protein	gnl\|CDD\|236322	PRK08649, PRK08649, GuaB3 family IMP dehydrogenase-related protein.	0

>NC_019689.1|WP_015142871.1|1226350_1226641_+|hypothetical-protein
MTLEQMQEVLNKMLSVQQELQNSQLKFTESLSELKDDISGLTQSVKRIDKMVARLSISQANFWETQADYYDRLEKVEETHNKIAEILERLTKQEER
>NC_019689.1|WP_015142870.1|1224353_1225706_-|nicotinate-phosphoribosyltransferase
MIEDQQLIFSSEDYSLLTDLYQLTMVACYVGEGLEDKPASFELFVRHFPDKFGYLIAMGLAQALDYLEKLHFTNQQLEALQNTGIFAHAPAKFWSLLESGRFTGNVWAIPEGTAIFANEPLLRVEAPLWQAQLVETYLLNTINYQTLIATKAARMRDVAGKDAILLEFGTRRAFSPQGSLWAARAALAGGLDSTSNVLAALKLGRKPSGTMAHSLVMAIGAIEGSEDDAFSAFHRYFPTALLLIDTYDTIAAAERLAEKVKAGKIEVTGVRLDSGDLAELSKKVRSLLPDITIFASGDLDEWEIVRLKEAGACIDGYGLGTKLVTGSPVNGVYKIVEIDGIPTMKQSSKKATYPGRKQIFRRQENSKILSDRLGLAQETANSDEQPLLELVMQQGKPVNPPETIETIQKRTQASVASLPPETRRLNNPIPVPVNISNALESLRLSWIANH
>NC_019689.1|WP_041392835.1|1223679_1224246_-|nicotinate-nucleotide-adenylyltransferase
MTKIALFGTSADPPTAAHQAILEWLSEHYDWVAVWASDNPFKGHQTSLEHRMEMLRLLIEEIKTPRKNIRVYEELSHLRSLISVEKAKELWGNEAEYHLVIGSDLVNQIRRWYRFEELLKQVQILVIPRPGYPIAEEDLEALHSLGGKCIVADLDAPAISSTAYREKRNKNIVTQPVKEYIKREKLYI
>NC_019689.1|WP_015142868.1|1222948_1223683_-|NUDIX-hydrolase
MKTDEQKLVNKTELENFKVGVDNVIFSVDTQLNRLLVLLIKRKDEPFSGQWSLPGTLVRKGEALEQSAYRILAEKIQVKNLYLEQLYTFGGPWQAPRESPDSYGVRYLSVSYFALVRFEDAKLIAENLSSITWYPIQRVPKLAFDHNEILEYGYRRLRNKLEYSPIAFDVLPEVFTLNDLYQLYCTILGENFSDYSNFRSRLLKLGFLCDTGVKVSKGAGRPASLYRFDAEAFAPFKDKPLVFI
>NC_019689.1|WP_015142867.1|1220841_1222536_-|NAD+-synthase
MKIAIAQLNPTIGDLSGNAKNILEAARQAAKEGVRLMLTPELSLCGYPPRDLLLSSEFVESMSKKLHELAQQLPTQIAVLVGTAEPNPYATSKGQKPLFNGTALLEGGKLQKIFYKRLLPTYDVFDEDRYFEPGYQTNSFTIKSDSQSKIHIGVTICEDLWNEEEFWGKRNYEINPIEDLAELEVDLIVNLSASPYTVSKQKLREAMLSHSASRYQTPIIYVNQIGGNDDLIFDGNSVAFNRTGNVVCRAKAFASDLKIIELDEQTKDLLPTAIAPLPETEEEEIFSALVLGVRDYARKCGFSQVVLGLSGGIDSSLVAAIAAEAMGAENVLGVLMPSPYSSEHSITDAEALVKNLGIKSQKLPIGDLMKSYDRLLEPLFAGTEFGIAEENTQSRIRGNLLMAISNKFGHLLLSTGNKSEMAVGYCTLYGDMNGGLAVIADVPKTRVFSICRWLNRTREIIPNNVLIKSPSAELKPGQVDQDSLPPYEILDDILERAIHHHQSTAQIVESGHDLEVVDQVMKLIARAEFKRKQAPPGLKITDRAFGTGWRMPIASRWLPPNPSN
>NC_019689.1|WP_083888329.1|1218764_1219655_+|glycine--tRNA-ligase-subunit-alpha
MNFQSIVVTLNQFWSDRGCLIVQPYDIEKGAGTKNPHTFLRALGPEPWSVAYIEPCRRPTDGRYGENPNRFQHYYQYQVLIKPSPDNIQDIYLDSLRALGIHPEDHDIRFVEDNWEDAAVGAWGTGWEVWLDGMEITQFTYFQQCGGIDCRPVSIEITYGLERLAMYLQDVDAIIKIRWNDRITYGEIFLQAEIEQCTYNFEASNPDLLFSLFDLYEQEAKQLLDRELVWPSLDYVLKCSHTFNLLDARGVIAVAERTRYIGRIRHLARQVAQLYVRQREKSGFPLLNNQPEVISK
>NC_019689.1|WP_015142864.1|1213143_1213404_-|MoaD/ThiS-family-protein
MSQALVNIRVKLFAAYQEAYGVSELKLSFTQGTPVQAVLDYILREHPELESWRNLTRFGVNLQFVEPDILLCDGDEVVLIPPVSGG
>NC_019689.1|WP_041392833.1|1211916_1213080_-|GuaB3-family-IMP-dehydrogenase-related-protein
MDIAIGRGKTARRAYGIDEIALVPGVRTLDPSLADTRIRIGEIEREIPIIASAMDGVVDVRMAVLLSELGAMGVLNLEGIQTRYADPEPILDRIASVGKSEFVGLMQELYAEPIKPELIQQRIKEIKERGGIAAVSLTPAGAVKYREDVTSAGADLLFVQATVVSTAHLSPESTIPLDLVQLCQELPIPVVLGNCVTYEVALNLMKAGAAAVLVGIGPGAACTSRGVLGVGVPQATAVADCAAARDDFERETDKYIPVIADGGIVTGGDICKCIACGADAVMIGSPIARAAEAPGRGYHWGMATPSPVLPRGTRINVGTTGTIAEILTGPAKLDDGTHNLLGALKTSMGTLGAKNMKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK
>NC_019689.1|WP_015142861.1|1210954_1211320_-|Mo-dependent-nitrogenase-C-terminal-domain-containing-protein
MSLNNTSTKSIVLSGWIENDLAKTKTNAKRSFSWKSVDLLKPLRMRLNSIEIDRPKLAHRICRLIPARCPFARKIRLFGRTIANIPPLCKINPLYEDLMALRFRALCYLADECGEDISAYC
>NC_019689.1|WP_015142860.1|1210134_1210905_-|hypothetical-protein
MAIIALKAWYLEHYAPIKEIVKRPHDLRLSRNSLLKSGMRADFLDDAQAIQESVWFQRYLEGNLVEFYIEGSGSYVISNIDLLSHEIYFTKQDISAWLEPIVFLSCQNEYPQASEALRSALAEAIETFNRRSRFPITLEESLRSTDTTVRLSETQLRKIRKSLLFIADGTPITSIPQERQPQLILSPLVCVELGYALESKRAGQILLVQMERPDLIGKFSFDLPQHQQLIFKTATELNKTLPSMLKTLLQRFNLHY
>NC_019689.1|WP_015142873.1|1229969_1232438_-|ATP-dependent-helicase
MPFDSNDSATNRITTVSSWTETSVRTDLEEKLEQLRKSLRPGQRDLADWKGGQMAISAVPGAGKSHSLSVAAAIAIARYQLHARKQLVIVTYTRSAAASIKDKIKQQLKELQLPQTGFSVQTLHGLALNIANRYPELSGLNLDSATLITPNSTHRIVRACVEQWINTAPRRYQILLEGMQFDGEEAEKLRRHSVLRTEVLPNLAHTVIREAKSSGLSPEALAEISQQTNDDYQILAIAAGLYQQYERLMRSRDLIDYDDMILAALRVLENESIRQIWQNQVFAVFEDEAQDSSPLQEKLISILAADPSNLNAPMNLVRVGDPNQAINSTFTPADPLYFNWFCTTCQIQGNLATMDRAGRSNQRIIDAANFILEWVNNTWRSKDKQSQQQELQNSEYVLHRRYINQKNLESKNTYVAQKIELPFREQKIYPVDAGDPQKLANPKAKGLGLEIYTPEDTYETVALIQKRVIKLLTEDSQRNAAILVRENRQGRFLAEQLTDSLRQHNIKVYEVGESDRFSQIPEEILKLLQFIDRPHSPDNLKAALEILERRDLIAAQDLNALATYPEQFLYPSPLDLPQKPQVAQARRYCCNLLRARLELPHYQLIPFLGMTLKYTGSELATVQKLSERVHQQIVGNSSLKTAIAALNEIASSECFEAVEEETDDRYTSQGQLTIITMHKAKGLDWDYVFIPFLHEDVLPGKPWVPTSSKFLGDFTLAEVARAQIRTAVHAQYLDPDSLPPIPQPLEAWEEAGKLKKAEEFRLLYVAMTRAKRLLWMSAETKAPFRWNTFRGDRVSNLQDKTPCPILSALMRQFPESVVKIGF
>NC_019689.1|WP_051036386.1|1232823_1233054_+|hypothetical-protein
MGNETGCRDFFYSWGYILLESVQKLLTQEIPQPSLAGILIAIASLITMPILAWQKDRLGQNLDSRALIADSQETLV
>NC_019689.1|WP_041391877.1|1233095_1233281_+|hypothetical-protein
MIADSQETLVCGWLSAILLLGLGLNYTFGFWQADPMAGIAIAPFVFKEGWETWEESQQEED
>NC_019689.1|WP_015142874.1|1233364_1234243_-|4-hydroxybenzoate-solanesyltransferase
MTQSQQLPEPVWLTIFRLLRWNKPEGRLILMIPALWAVFLAAHGTPPLPLVVVIILGSLVTSAAGCVVNDLWDRDIDPEVERTRDRPLASRALSVRVGIVIALIAFACAAVLAFYLNSLSFWLCVAAVPVIICYPLAKRVFPIPQLVLSIAWGFAVLISWSAVTAKLDSATWVLWGATIFWTLGFDTVYAMPDREDDRRVGVSSSALFFGKYAADAVGVFFALTAGSLAYLSLVMRLHWGFWIAWAIAVVGWVGQYIRLSTPEIPNSIYGEIFRQNVWLGFILLSGMILGSI
>NC_019689.1|WP_015142875.1|1234364_1236020_+|Ppx/GppA-family-phosphatase
MVDSVDKVKTNRTELATPSKTEPTILAAIDIGTNSIHMVVVQIDPILAAFTIIAKEKDTVRLGDRDPKTGNLTPEAMQRAIAALQRCKDLAISKNADHIVAVATSAAREAPNGLEFLQRIESEVGIFVNLISGYEEARRIYLGVLSGMDFQNQPHVIIDIGGGSTELILADSQEPRFLSSTKVGAVRLTREFITTDPISEAEFAYLQAYVRGMLERATDELRFYIKPGEQLRMVGTSGTIETLAIIHALEKQGEVPNPLNGYQISRKDIREMVKRFAAMNCEQRSAIAGMSEKRAEIILAGAIVLQEAMSLLNLETIVICERSLREGVIVDWMLTHGLIDSRMRYQSEIRERSVIKIAHKYQVNLEHCERVANFALSLFDQLQGYLHSWGSEERELLWAAAILHNCGLYISHSAHHKHSYYLIRNAELLGFTEIELELIANIARYHRKSKPRKKHEPYSKLPDNYRKAIKQLSAILRIAVALDRRQIGAIEKFECKYDSEYKTLHLHLFTSNPDDDCALELWNLDYEKGVFEEEYGVRLVATLAVSRAAVS
>NC_019689.1|WP_015142876.1|1236202_1236940_+|SDR-family-oxidoreductase
MLSLGLEDKVIFVTGGNRGIGATVVSLLQQLGAKVAYTYRSSNHYYDGDLPNGALPIEADVTDAAALEAAARRVEEKLGAVYGVVANAGITKDNFYPKLTHDDWDAVIDVNLKGVNHTIKPFISGMYERGEGSLVCVSSISGERGNVGQTNYAATKAAVIGLVKSLAREAARYGVRANVVSPGFIETDMTKGLPDKVKDKVTAEIPFRRFGKPEDVAWAVAFLLSPVASNYVTGEVLRVNGAHHT
>NC_019689.1|WP_015142877.1|1237021_1237645_-|TenA-family-protein
MLSKELWQSHQELARACLENSFVRGIATGTLEREKFAFYVGQDAFFLEAFARAYSIAAAKAYDWEGFCTFHRLAEGVLEELRLHEDYANQWGVNLREVKPAPATRRYTDFLLATAWGSDVGVTAVAMSPCMRLYAFLGQQLAQNGIPDHQYANWILAYSSPEFEKLAQLLESLCDRYATATDLVRETYRYALLCEEDFFTAAWESKV
>NC_019689.1|WP_015142878.1|1237658_1238435_-|pentapeptide-repeat-containing-protein
MKFNLLAITTILSAIGLSIPVRAENLEHLRQLLSTRECSQCELSGAGLVMSNLAGVNLRGANLSGANLSQANLTGADLSGANLAGASLYGANLVGANLAGAILDGTDLRSAYLTNANLIGTKLDTAYVQGAYGIPTYAGSPQQFYGWGLVESKKGNHVAAIEHYNQSLSLDPQFAPAYLARGIANYRLGKQGQAKKDAEMASQLFQKQQNKPGFDASQNFLVTMEAIRQSNQEPEETSGFMRFLQGAASLLLQFLVAF
>NC_019689.1|WP_015142879.1|1238618_1238888_+|glutaredoxin-3
MAAKVEIYTWSSCPFCIRAKALLGKKGVEFTEYVIDGDEEARALMAERANGRRSLPQIFIDNRHVGGCDDLYALESQGQLDPLLQGNVA
>NC_019689.1|WP_015142880.1|1239098_1240070_+|glutathione-synthase
MKLAFIIDPISRLDPGHDTSVALMEAAQTLGHEVWITQVHQLSVIGGTAWATLQKVRLTPVKLANGRWVSDPNWYQLSDGVLTCLEDMDAVFMRTDPPVTMRYLYATYILELINPAKTLVINSPQGLREANEKMYTLQFHQVMPETIVSQDKSIIRQFVEEKKFAVLKPLGGKAGEGILFLDPSDRNFNSIIEVSTQHGREPVMIQQYLPEAKDGDKRIIMLNGEPIGAVNRVPTGSEFRGNMAVGGKVEKTNITEREREICAAVGPKLRDNGLYFVGLDVIGGYLTEVNVTSPTGIREIDRLNNTNLGKQVIQWLEKAIPSP

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Crispr_ID: NC_019689_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_4

2138316-2138410

Orphan

Consensus_repeat	Method
TCGATCGAGAAGCCAAAGACTATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019689_4

>merge|NC_019689|4|2138316-2138410|CRISPRCasFinder
TCGATCGAGAAGCCAAAGACTATTGTAAGCAGCAAGGAATGAAATAATCACCGTAGAAAGACTTACAGCGTTCGATCGAGAAGCCAAAGACTATT

>NC_019689|4|4|2138316-2138410|CRISPRCasFinder
TCGATCGAGAAGCCAAAGACTATT	GTAAGCAGCAAGGAATGAAATAATCACCGTAGAAAGACTTACAGCGT
TCGATCGAGAAGCCAAAGACTATT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015143624.1\|2123759_2125001_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379084
NC_019689.1\|WP_015143639.1\|2152408_2152957_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NC_019689.1\|WP_083888336.1\|2149637_2152007_+\|bifunctional-metallophosphatase/5'-nucleotidase	unknown	unknown	gnl\|CDD\|277369
NC_019689.1\|WP_015143627.1\|2126583_2127762_+\|sulfate-adenylyltransferase	unknown	unknown	gnl\|CDD\|235227
NC_019689.1\|WP_015143623.1\|2122375_2123671_-\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|180954
NC_019689.1\|WP_015143636.1\|2142485_2143109_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_019689.1\|WP_015143634.1\|2140725_2141265_-\|RNA-binding-protein,-contains-THUMP-domain	unknown	unknown	gnl\|CDD\|214952
NC_019689.1\|WP_015143630.1\|2132139_2134566_-\|phosphoenolpyruvate-synthase	unknown	unknown	gnl\|CDD\|235809
NC_019689.1\|WP_015143633.1\|2139418_2140666_+\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NC_019689.1\|WP_015143625.1\|2125255_2125768_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NC_019689.1\|WP_015143626.1\|2125996_2126470_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_019689.1\|WP_015143631.1\|2135185_2135965_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NC_019689.1\|WP_015143642.1\|2156254_2159146_-\|beta-phosphoglucomutase	unknown	unknown	gnl\|CDD\|224471
NC_019689.1\|WP_015143632.1\|2136091_2137267_+\|LptF/LptG-family-permease	unknown	unknown	gnl\|CDD\|367632
NC_019689.1\|WP_015143637.1\|2143143_2143692_+\|YqeG-family-HAD-IIIA-type-phosphatase	unknown	unknown	gnl\|CDD\|225090
NC_019689.1\|WP_015143629.1\|2130377_2132015_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015143640.1\|2153276_2154677_-\|(Fe-S)-binding-protein	unknown	unknown	gnl\|CDD\|223325
NC_019689.1\|WP_015143628.1\|2127935_2130212_+\|caspase-family-protein	unknown	unknown	gnl\|CDD\|334197
NC_019689.1\|WP_015143641.1\|2154729_2156022_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_019689.1\|WP_015143635.1\|2141986_2142421_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015143624.1\|2123759_2125001_-\|hypothetical-protein	gnl\|CDD\|379084	pfam13240, zinc_ribbon_2, zinc-ribbon domain. This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.	0.00375934
NC_019689.1\|WP_015143639.1\|2152408_2152957_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.27057e-61
NC_019689.1\|WP_083888336.1\|2149637_2152007_+\|bifunctional-metallophosphatase/5'-nucleotidase	gnl\|CDD\|277369	cd08162, MPP_PhoA_N, Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain. Synechococcus sp. strain PCC 7942 PhoA is a large atypical alkaline phosphatase. It is known to be transported across the inner cytoplasmic membrane and into the periplasmic space. In vivo inactivation of the gene encoding PhoA leads to a loss of extracellular, phosphate-regulated phosphatase activity, but does not appear to affect the cells capacity for phosphate uptake. PhoA may play a role in scavenging phosphate during growth of Synechococcus sp. strain PCC 7942 in its natural environment. PhoA belongs to a domain family which includes the bacterial enzyme UshA and several other related enzymes including SoxB, CpdB, YhcR, and CD73. All members have a similar domain architecture which includes an N-terminal metallophosphatase domain and a C-terminal nucleotidase domain. The N-terminal metallophosphatase domain belongs to a large superfamily of distantly related metallophosphatases (MPPs) that includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.72125e-102
NC_019689.1\|WP_015143627.1\|2126583_2127762_+\|sulfate-adenylyltransferase	gnl\|CDD\|235227	PRK04149, sat, sulfate adenylyltransferase; Reviewed.	0
NC_019689.1\|WP_015143623.1\|2122375_2123671_-\|adenylosuccinate-lyase	gnl\|CDD\|180954	PRK07380, PRK07380, adenylosuccinate lyase; Provisional.	0
NC_019689.1\|WP_015143636.1\|2142485_2143109_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	8.72843e-28
NC_019689.1\|WP_015143634.1\|2140725_2141265_-\|RNA-binding-protein,-contains-THUMP-domain	gnl\|CDD\|214952	smart00981, THUMP, The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.	2.74142e-06
NC_019689.1\|WP_015143630.1\|2132139_2134566_-\|phosphoenolpyruvate-synthase	gnl\|CDD\|235809	PRK06464, PRK06464, phosphoenolpyruvate synthase; Validated.	0
NC_019689.1\|WP_015143633.1\|2139418_2140666_+\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	5.23614e-159
NC_019689.1\|WP_015143625.1\|2125255_2125768_+\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	9.9156e-53
NC_019689.1\|WP_015143631.1\|2135185_2135965_-\|SDR-family-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	3.33207e-102
NC_019689.1\|WP_015143642.1\|2156254_2159146_-\|beta-phosphoglucomutase	gnl\|CDD\|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	0
NC_019689.1\|WP_015143632.1\|2136091_2137267_+\|LptF/LptG-family-permease	gnl\|CDD\|367632	pfam03739, YjgP_YjgQ, Predicted permease YjgP/YjgQ family. Members of this family are predicted integral membrane proteins of unknown function. They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this.	3.42847e-72
NC_019689.1\|WP_015143637.1\|2143143_2143692_+\|YqeG-family-HAD-IIIA-type-phosphatase	gnl\|CDD\|225090	COG2179, COG2179, Predicted hydrolase of the HAD superfamily [General function prediction only].	2.21915e-61
NC_019689.1\|WP_015143626.1\|2125996_2126470_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	3.6921e-38
NC_019689.1\|WP_015143640.1\|2153276_2154677_-\|(Fe-S)-binding-protein	gnl\|CDD\|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	7.12672e-101
NC_019689.1\|WP_015143628.1\|2127935_2130212_+\|caspase-family-protein	gnl\|CDD\|334197	pfam00656, Peptidase_C14, Caspase domain.	1.00764e-14
NC_019689.1\|WP_015143641.1\|2154729_2156022_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.03352e-77

>NC_019689.1|WP_015143632.1|2136091_2137267_+|LptF/LptG-family-permease
MKFDKPLYYLLKSQLGGISIMDRYIVTELIGPFLLSIGIFSSLGVAIGYSSDLINKVIESNLPIVQAAQVLLLKVPEFISYALPISVLLSSLMAFGRLSNNSEIIALRGCGVSLYRIVAPAIALSLLVTGITFLFNELVVPAANYRATAILVESIQEEHPFWQTRDIFYPDYEKVTLPNGETRQRLKSLFYAKQFDGKQMKMLTILQWLGENLNQIIISDSASWNGEQQTWDFFNGTIYKIASDTSYDETLSFDRRQIPFSRVPFDLAVLGRDPDEMNIAQAQAYMKLLRQTGDEKKLLMFEVRTQQKMAFPFVCLVFGVVGSALGSRPQHVSRATSFGLSVAIVFLYYVLGFSLGSFGTIGIFSPFLAAWLPNFIGLGVGLWLLGRTDSD
>NC_019689.1|WP_015143631.1|2135185_2135965_-|SDR-family-oxidoreductase
MKIALITGASSGIGAAFARELAARKTDVVLVARSEEKLARLAKQLQEQFQVRSEVIVQDLIAPGATQSIADAISEKGLTIDLLINNAGFGDYGAFVDRDLQRQVEMIQLNITALVELTYRFLPGMKQRGSGGIINVSSIAGFQPLPYLSVYAATKAFVLNFSEALWAENQGTGVRILALCPGATESEFFNVAKFPSSFAGENGNRYTPAEEVVRDALKALEQNQSHIVTGGVGNKLMVNLSRFFPRDWLVSAVEKQFRG
>NC_019689.1|WP_015143630.1|2132139_2134566_-|phosphoenolpyruvate-synthase
MGSIEREKALILWFEEVGTEDVGLVGGKNSSLGEMIQQLQPKGINVPNGFATTAHAYWHFIESAGLENKLRKIFADLDVDDVNNLQERGQYARSLILNTPFPADLQEAIANAYTSLCERFGSATRQQVDVAVRSSATAEDLPEASFAGQQETYLNVYGIKAVIESCHKCFASLFTDRAISYRQHNGFDHFAVALSVGIQKMVRSDLASSGVMFSIDTETGFKDAVFITAAYGLGENVVQGAVNPDEYLVFKPTLKQGYRPILDKRLGSKAIKLVYDTGGSKLTKNVAVPKADRGKFCLNSDEILQLAKWAIQIEDHYSQVRGTYTPMDIEWAKDGITGELFIVQARPETVQSQKSGNVLKTYRLKESTQVLATGRSVGAAIGQGKARVILDVGKLNVFQPGEVLITHRTDPDWEPIMKKASAIVTNQGGRTCHAAIIAREMGIPAIVGSGNGTEVIKSGQEVTISCAEGEEGRVYEGLLDFEVTETTLDNLPRTRTQIFMNVGNPEQAFSLASLPCDGVGLARLEFIIANHIKAHPLALIHFDELQDDSVKAEIAELTKLHQDKPQFFVDKLARGIGTIAAAFYPKPVIVRMSDFKSNEYANLLGGRQFEPKEENPMLGWRGASRYYDPLYQQAFALECEAILKVRDRMGLTNVIPMIPFCRTPEEGQRVIEEMAKNGLKRGENGLQVYVMCELPSNVILADEYCEVFDGFSIGSNDLTQLTLGLDRDSALVAHLFDERNRGVKRMVKMAIEAAKAKGRKIGICGQAPSDYPEFAKFLVELGIDSISLNPDSVLSTLLKVAEVEGVKA
>NC_019689.1|WP_015143629.1|2130377_2132015_+|hypothetical-protein
MNTLPQPTKRRLKKIPQIPSVWEGDRRSLSSFRAHLESDTEGNGECIIWVDGSEGFVRAMDVVSPEMGPEAVVRTLLRAIETPHSPAKPARPQKIVVRNREIQFFLRGALQNLDIAIDYVPELPLIDELFRSFEDLSGTRPPAIPPLYDTALKDIARELWQAAPWEVLADRDVLAIELNRWDVETIYACVMGMLGKEYGVILYRSLDSLKRFRLAALEEKSVEQLEKAFLAQDCWFLNYEPVRDVEWEEEEFDLADLPPSQIRPLFGSVHPYEGIRPYLDEEEAKAVYVLLQALLRFFRASKRGLDREPIDRISKRYRIPTSPAPDARETIPVTVSTLPELSAELLDIMETIEAEEDEKESQLSVPLRDDLVPDNAFLSVGMVPWELVETLRHHPKIYYQNQGASPKGEGMPVVLIQTSRPKAKALIETLKNDGGLKAICFNPGEDPFTGVNYDLGIFQTFNENFYIFGEFVSDDPEHVQARKKWDRRCHKTERYCGLIVAMGVTGTSRGNPQLPDMMALFETKALDAKELAMGVLQLMPEFEEL
>NC_019689.1|WP_015143628.1|2127935_2130212_+|caspase-family-protein
MGLNRRTFLQKAGLGLLALGASHSRLPLGINRYYQTLAAPTPRKLALLVGINEYPDSTSLKGCLTDVELQQELLVHRFGFKSQDILTLTGQQAGREAIESAFLEHLIEQATPGDVVVFHFSGYGRQVKVPETVDKSYRLVNSLMPSDSILTTKGTPATNDLLEETLLLLGRSLATNKVTFVLDTSYCSTGRLLQGNLRVRSFPTLAENPNPEELATQEQLQRRLNAALPTWKSTGTSSSGTILSAAGRERVATEIAIDGLNAGLFTHTLTQYLWQVAPASRILVAMTRTAEQMAVAIGMCQEPQQISGDKQPLLTYYLMPENPIGAEGVITRLEDDRAVEILLAGLPAYVLAHYGLNSCLMVVPSPDSKEVVVQIRSREGLKAKARLLEAPDERPMPLKVGQLLQESIRILPRHLSLTVALDPSLERIERVDATSALASVAAVAGAIAAGEQAADCVLSKVRAADSSGTTLASTQDNLGVALGWEGYGLLSAGGVALANAKGSGSEAVKSAIARLEPQFKQLLAAKWWRLTANEGSSNLAVSATLEIAGKPPQSLIRRDTRRQAFGADNSSLPANTTATGETAVLPRLPIGTQIQYRLENLSDRPIYFLLLGIDSGGRAIALHAPRLARESAPAEASSQLKERCLLPGEQLVVPNPTASVNWLASAPAGLAEMHVVCAHAPFAKTVEALSSKEYLKGDREQIFKVPNPLEVALALLQDLHDASAVKSEIIGSLTDVYALDTKAWATLSFVYQVVSSSQ
>NC_019689.1|WP_015143627.1|2126583_2127762_+|sulfate-adenylyltransferase
MTTHTDGIAPHGGQLINRVATPAEREEFLAQAEYLPRVRLDERATSDLIAIAIGGFSPLKGFMEQADYEKVVDDMHMVNGLAWSIPVTLPVSEEVAEPLKEGNWVRLDDSDGKFIGVLELTQKYRYNKAHEAINVYRTDDVNHPGVRVLYEQGAINLAGPVWLLQRDPHPLFPKYQIDPAESRKLFKEKGWQTIVGFQTRNPIHRAHEYIQKCALEVVDGLFLHPLVGATKSDDIPADVRMRCYEIMLEKYFPKERVILAINPCSMRYAGPREAIFHAILRKNYGCTHFIVGRDHAGVGDYYGTYDGQKIFDEFDPQELGIVPMKFEHAFYCTRTQQMATSKTSPSTKEERIHLSGTKVREMLRRGELPPPEFSRPEVAAELAKAMMQANGN
>NC_019689.1|WP_015143626.1|2125996_2126470_-|universal-stress-protein
MGYQKILVALDRSSQSEIVFDSALEIAKEFGAALMVFHCLPIETPAMTPYANLYGEELINFAQAIHQRLEEETQQVQQWLRKCSQKAIEREVSTELDYKVGDAGPWICEMASNWGADLIVLGRRGRRGLAEMFLGSVSNYVIHHASCSVLVVQGGSA
>NC_019689.1|WP_015143625.1|2125255_2125768_+|N-acetyltransferase
MSCAISQKQIRDATEADLPAIVEIYNASIPSRMATADLEPVSVESRKRWFDEHSPTSRPLWVMENNNTIVGWLSFQSFYGRPAYHKTAEVSLYISVLHRRQGIGEQLLQQAIQKSPELGLDTLVGFIFAHNRPSLQLFAKYHFQQWGYLPKVAELDGIKRGLVIVGKKVG
>NC_019689.1|WP_015143624.1|2123759_2125001_-|hypothetical-protein
MLAQIRHLLSQFFSKSRTINNEPLNKVSLIVIILIDIFIAINVFAGLDDISQWYISPSQAYPCYFEWENYRKDTTNDKDYRIVRLAFSYDTSDRFSFQQTYQKAEEGHLGRVSKTCLRYGDYKDKINNSENQQIIKTIDRKQSEISTIEQNNRNIRAQYDSTLLEKIAGQPRERSINLIAAEKAKQELERNNRQISTLKKDISNLKNKLVTKPESVSFIAFLKDGEKFREVEGGYQQASFWYPSIQLAFQSLFLVPLILIALSVHNFGQRKGYGLISLMSWHLLVIFFIPLILKIFEFLQIGAIFRFIFDIIRTLFGGLLFLLSYVYILLIPPIGFGIIKFFQKIVFNTKSQAASRVQKSRCIKCAKKIRPHDSYCPHCGYYQYIECQHCNNLTYKHLPYCKQCGSAQNLDNL
>NC_019689.1|WP_015143623.1|2122375_2123671_-|adenylosuccinate-lyase
MIERYTLPEMGEIWTETYKLKTWLQVEIAVCEAQAELGYIPAEAVEEIKAKANFDPKRVLEIEAEVRHDVIAFLTNVNEYVGDAGRYIHLGLTSSDVLDTALALQLVASLNLILECLEELIQAIRYQAQQHRNTVMVGRSHGIHAEPITFGFKLAGWLAEVLRNRDRLVRLRENIAVGKISGAMGTYANIDPRVEAIACQKLGLDPDTVSTQVISRDRHAEFVQQLALLAASIERFAVEIRNLQRTDVLEVEEFFSKGQKGSSAMPHKRNPIRSERLTGMARIIRGHVVAALENVALWHERDISHSSVERVMLPDTCILIHFMIKEITDLVKHLLVYPENMKRNMNVYGGVIFSQRVLLALVAKGMSREEAYTVVQSCAHQAWNTPEGNFHDLISKDPRVTQLLSPQEIESCFDPQQHLKNLDEIYQRLGI
>NC_019689.1|WP_015143633.1|2139418_2140666_+|molybdopterin-molybdotransferase-MoeA
MLSVKEAESIILELVKPLDIRKDTEVVTLKDATGRILAQPVTSDLDFPYWDNSAMDGYAVKFADVESCSAESPAILEIVEEIPAGVQPKSAIASGQAARIFTGAMMPEGTDTIVIQENTKREGNCVLVLSPPSRSNAFVRQRGSFYQAGNPLLEPGIVINAPEIAVLATAQCTQLTVYRRPRVAILSTGDELVPPDRTLQPGKIVDSNQYALAAFVASQGGIPIRLGIVPDKPDLLKEKMTQAIATADIVLSTGGVSVGDYDYVEQLLAELGGEIRIRSVAIKPGKPLTVAAFANGCTYFGIPGNPVSALVSCWRFVQPALRKLSGLSDNWLPTFMKVRSRDRLISDGKRETYLWGQLQSVDGVCEFQLAGGAQNSANLINLARTNSLAVLPVGQTAIASGQEVDVMLVAGAFGR
>NC_019689.1|WP_015143634.1|2140725_2141265_-|RNA-binding-protein,-contains-THUMP-domain
MRDWNVVVNLHEHSFQKAFKELQGFGIVSETDFFNVLAMKVGDINRFLENLQEWIANHPDFLTRIARIVPVTNTFTFQSPEEFEAKAKEIVLQWVPQLAGKSFHVRIHRRGFKGRLSSLDEEHFLDKILLEALEKAGTPGRITFENPDAIAIVETLGQWAGLACWKREDLERYPWMRID
>NC_019689.1|WP_015143635.1|2141986_2142421_+|hypothetical-protein
MSVNYQGKIITLWTTFLLGTIFHTDLGLMPLFHGKSVAHSHEIGDISWVMWLMLAFFVLPMFAIIATAFTESKRFRVAHFGLTVFYSVMNLLHIILDLFVTPIAWYQITLMVILFAIGLLLNVVSFQWMQHHPRGKRLQEQVSF
>NC_019689.1|WP_015143636.1|2142485_2143109_+|class-I-SAM-dependent-methyltransferase
MATILRPLSYKYQWLYDGISHLAALGVGGEKRFRHLALQDLDIKPDTEILDLCCGAGQTTRFLVRFSNRVTGLDTSPLALQRAARSVPQANYIEGLAEKMPLPDEQFDLVHTSVALHEMETEQLQQILSEVYRVLKPGGIFTAIDLHKPTNSLFWLPLAIFMWLFETETAWQLLEIDLVERLKAVGFSDCRQRLYLGGSLQVIQARK
>NC_019689.1|WP_015143637.1|2143143_2143692_+|YqeG-family-HAD-IIIA-type-phosphatase
MLKVDLLQPDLILGDTVLGITPEILHHYQLKGLVLDVDETLVPLRVREVSEELMQWATEIRQVAKIWLVSNNLSENRIGKIAQSLNAPYTWGARKPSRRKLRQALQALNLPASQVAMVGDRLFTDAIAGNRLGMFTILVEPMVDPAIAARSYPIRNFEVWLSKKLGVSLTTTQQMFTKSDET
>NC_019689.1|WP_083888336.1|2149637_2152007_+|bifunctional-metallophosphatase/5'-nucleotidase
MTESKPEPASEAFTLQLLHGSDFEAGIEALDDAPRFSAVINGLRDDYKNTLVLSSGDNYIPSPFLFAASDPSLANTPVGTEGIGRADIEILNQIGIQASAFGNHEFDLGTREVQGLISPDENYRGTQFPYLSSNLDFSTDSNLSGLVTANGQEASTIPNTIAESTVITVNGEKIGIVGATTPLLPSISSSGDVGVIPSDPNNVAALAAEIQKTVDELTATGIDKVVLLSHFQQLRIEQAVAPLLRDVDIIVGGGSHTLLSDESDRLRSGDTSGGTYPILTTSASGEPIALVNTDANYRYVGRLVADFDANGVLVPESIDPNISGAYATDEQGVTDVGGTPDPEVVAITDTLGNVINEQDGNIFGKTDVFLRGDRTFVRTEETNLGNLTADANLAAAQAVDPSTVISIKNGGGIRSSIGVIEAAGGSTDPDDFALLPTAANPEASKEEGDISQLDIANSLRFNNGLTLLTLTAEQLLQTIEHGVAATASGETPGQFPQVSGISFSFDPDLPEGDRVLSLAVTDDEGNVTDVVAQNGELQGDPNRTFRTVTLDFLAGGGDDYPFATFANTNPVELVTEDSENPAPSNRTGVATFAADGSEQDALAEYLAANFNEQNPFDVADVAPEKDTRIQNLNFREDTVLSANVAPASTELPETVFGTSGDDVFDAADPSGNFDGSKDIVSAGEGSDRFFLGAGEGDNLLTGGIGADQFWITSSDDGLPSVANTITDFNSTEGDVIGFADTSLSYGALGGDWNLRQAGNDAVIEAFGQDVAILQGIQADSLTETNFVFG
>NC_019689.1|WP_015143639.1|2152408_2152957_-|DNA-starvation/stationary-phase-protection-protein
MPKLNIGLTEEQRQGVIGLLNIDLADFYLLLIKTKKYHWDVIGPQFRSLHELWEEQYETLTANIDRTAERIRALGGYPIGTAQGFLQHSTIQEQPGTLPTANDMVMSLVNDHEQIIRNLREHVDRCSDEFHDEGTADFLTGLMEEHEEMAWMLRSFIEGEDLKPSGDRPGSEIKESIGVYSS
>NC_019689.1|WP_015143640.1|2153276_2154677_-|(Fe-S)-binding-protein
MQTSDKALNNPVRSIPNELKSFDVQNLLDKEIKGFDPKNPPKQDLIDTCVHCGFCLSTCPSYRVIGKEMDSPRGRIYLMNAINKGEAALDETTTQHFDSCLGCLACVTTCPSGVQYDQLIAATRPQVERNQPRSLKDKLIRTLIFNLFPYPNRLRIFLPLLWLYQKLGIQKLVRATGLLDRFFPRLAAMESILPEVNLKSLRDNLPDIIPAQGEKRYRVGVILGCVQRLFFSPVNEATVRVLTANGCEVVIPKTQGCCAALPAHQGQEEQAQALAKQMIDSFEGTGIDYVIINAAGCGHTLKEYNHILEDNPEYREKAKQFVAKVRDVQEFLAEAKLTTNLSPLTEKDLTIVYQDACHLLHGQKISLQPRQLLKQIPGVKLKEPIDAALCCGSAGVYNMLQPEVANELGQQKVKNLLDTGAELIASPNPGCSLQLKKHMQLKGQEIPLMHPMELLDYSIRGIKLKI
>NC_019689.1|WP_015143641.1|2154729_2156022_-|FAD-binding-oxidoreductase
MTYEIANQPETIAWEKVEPIWQKKIQGAIASQMPPSCLIFPKTQESLSEIIRSASEKRFSVLPCGSGSKLGWGGLVKDARLVVSTQHLDRIIEHAVGDLTVTVEAGVKLADLQKLLSQSHQFLPLDPAYPESATIGGIVATADSGSWRQRYGGVRDMVLGLSFVRADGQIAKAGGRVVKNVAGYDLMKLFTGSYGTLGIISQVTFRLYPIPEASGTIVLTGETNAIATATQTLLMSGLAPTAAQMLSGSLVNRLEIGKEIGLAIRFQSIVESVKEQIVQVESVAQQLGLKTSLYCHRDEIDLWQKLQQITRVPSSENAVTCKIAVRPNAASKILEQGERITNNQGAIAINISSGLGQLHCQYGEINQIKKMRSLCQENQGFLTILEAPTSVKKQLDPWGYAGNALEMMRRIKQKFDPNNIFSPGCFVSGI
>NC_019689.1|WP_015143642.1|2156254_2159146_-|beta-phosphoglucomutase
MSASAPSHHFIYTDWNLIETQFDPEQINHKGTVFTIGNGYLGTRGSFEEGYPRALSATLINGVYDDVPVVYTELANCPDWLPLTVSIDGENFRLDRGEVLSYQRQLDLQRGILSRKVRWRSPKGKTLDLYFERFASLADQNVLALRCQVTPLDFNGSIAVSASLNGYPENQGYNHWEELDRGDGDGTIWLHVRTRSSHIELGMAAKLLLSGTEGTFQVTSVPGYPTVETTLAVAAGQTATLDKIVTVFTSREAQTPAHVAQEKLAQLSSYAQLQSAHIEAWEKVWQHSDLLIEGDTKAQLAVRYNLFQLLISAPRHDNRVSIPAKTLSGFGYRGHIFWDTEIFILPFFIYTQPNVARNLLTYRYHTLNGARRKASYYGYKGAMFAWESAETGDEVTPRWALPNQPYAEDIRIWCRDREIHISSDIAYAIWSYWQATNDDEWMRDCGAEIILDGAVFWNSRIEWNPKQQRYEIREVIGADEYHEHVSNNAFTNRMVQWHLEKAIAVYQWLCDRFPERAAELEAKLGLTAKLRDRWEDMAANLWIPYDPTTGLIEQYEGFFNLEDIDLAHYEPRTRSMQEILGIEGANKRQVLKQPDVLMLLYLMRQSEEFPYNKEILQKNWDYYAPRTDITYGSSLGPAIHGILASDLGQSDEAYKLFLQAAMVDLEDVRGNAADGIHAASAGGVWQAVVFGFGGFKLTQEGPVATPHLPSHWQRLKFKIHWRSTWYDFDLRAEASEQKAEGKIQGVIFDLDGVLTDTAEFHYRAWQRLADEEGIPFDRQANEALRGISRRESLMRIVGDRNYTEAQLEEMMERKNRYYVESIQDITPDNLLPGARELLDELRAAGIKIAIGSASKNARMVIEHLGIADKVDAIADGYSVQLSKPAPDLFLHAAELLGLEPFQCVVVEDAESGIEAGLAAGMLTVGLGPAERVGKAHVVLPSLEGISWEDLQSQLFGTAAGSRY

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Crispr_ID: NC_019689_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_5

2419748-2423389

TypeIII-B

Consensus_repeat	Method
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	PILER-CR
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CRISPRCasFinder
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CRT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	PILER-CR
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	PILER-CR
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	PILER-CR

48 spacers

cas2,cas1,csx18,WYL,cmr3gr5,cmr4gr7,cmr5gr11,csm3gr7,csx1

The CRISPR arrays of NC_019689_5

>merge|NC_019689|5|2419748-2423389|PILER-CR,CRISPRCasFinder,CRT,PILER-CR,PILER-CR,PILER-CR
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTCAAGGGCACGACCGGCGAGGCGCGGCTAGGCAACCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGCCGGCCAGGGCCTCGGCCACGGTGCGCGCGGCCTCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACAAAACCCAGTTTTTGCGAGTTAACGGCTTGTAAAAAAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTAGGTCTGAGGCCTTGCGACAAGCACAATTAAAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTTGGTAAAAGGATTGACCGTTCCTGTGTTCACAAAGGTTGCAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCCTGAAAAAATAGGCGGATTTGTAGATACGCTTATTCCCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACAACATCCGCCGTCGGAGTTTACCTGCCCGTGCACCGAAGCCCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACATAAACCCAGTTGAGATTGGCCGCCATGCGCACCTCGCCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGGTCGTCCTGCCAGTCTCCCGCCACCAGCGGCGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCGGGCTTTGCCTGGAGCGCCCGGCGCAACACGGTGGTCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGTCAGGTCCACGACCCGAACCCCTCGCCTGTGCGTCACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGACTGTTTGAGTATCAATGAGGACATTTTAAAACAAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACACAAAATCACCAGCGAGCTGGAAACCCGCAATGCACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGTCGAGTATTACGACGCGCTGGCCGCCAGCTTCCTCGGCGAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTATCTTTTTTGGATTGTAAATCTATATCAAGATTAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTTCCTCATCGGATTCCCCACGCACGTCTACTGTTTCAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACATCTCTGGTTACCGGCAAGCGCTTGTTTATGCGGCAGTTGGCAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGGCTTACTTCAAGAAAGAGAACTCGGACCTCAGGCCACTTCAGACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCAAAAAGGTTTGGCAGAACCTAAGTCAAGAACATCAGAATGCCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCGATAGAAGCGAGTTTCAGCCGAGGAACGCCGGGTGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACAGCCGACCACTATAACGCGATGGTCATGTTCGTCAAACTACGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGCCCGTGTAGAGCGAGGCTGCGTCGGTCTGCTCTTCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTTAGTGTAATAGCGCTCGATTTTAGTGATTGGCTTTTCAATTATCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCACAATTCCAAAACATCAAAGCTAAGATAGAGACCGACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCACTTTCACCATCGAATCCGGTGACACCCACCAGGGTTCCACCCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGACAACCCCCATATCTTCAAACTCGGACGGTTCAAAGTCCGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTCAGCTCTCATAGCAGTGCTAAGCCCTTTAACTGCTTCCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACATCTCCGATGCTACAAAAATTGCCAATCGTGCCGAAAGCAAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTTTCATCGCCCATGAAAACCACTATCGACTGGATGCGCCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACATCGGTTTCCCCATTTCCAGCGTCAACAGTTGACCAAAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTCACCAATGCGGTCGGCATGGCACTCGCTGAAAAGCTACTCGCCGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGTCGCGGGGCTTGCCGTCGCGATATTTCCAACTTGGCCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTCGCGAAGGTGAACGGCGCGCGCGGCGACGCGGCGGGGCTCGCCCGGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACAGTATCCGGCTCACGCAACGAGAGCGCTCTTCATGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCTATTTACTTACTTATATAAGTAAGTAATTAATTTATATCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTTGATCGTCTTTATAGGCTGAATTGTTTTGCTCAGGCGTGTGTCCCAGCGATTGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTGGGCGCGCAATGCCTCTGTATTGCAAAAGTTGCCTTAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCACAAGTTGGCCGAGTCGCAGAAAAAATCGGCGCGGACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGATGGGCAACTGGGTCTTCGGGTGTGACATCTGCCAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACACTCCAATGTGGTTTTTACCTCTTGTTCCACACTGGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCTGAGTTGCATGCAGAGCCATAAGGGCATCGAGCTGAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACACCTGGTATCTTCGCAACCCTACTCGACACACCGTAGTTCTTTGTAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTTGGATAAAAATATTCGTTACCTTTTGCAGCTCCGCCAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTAAACCACGTAAAATTATTTCCACCCAAGACAATTGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGTGGTAGCTCTAACATTACATGGATAATGGTTTGTATCCGCGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACACCTTCGGGTCAGGTGGGCTGGTTGAGCTTCTTAAGCCCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACAACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACAACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC

>NC_019689|5|2|2419748-2419999|PILER-CR
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCAAGGGCACGACCGGCGAGGCGCGGCTAGGCAAC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GCCGGCCAGGGCCTCGGCCACGGTGCGCGCGGCCT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AAAACCCAGTTTTTGCGAGTTAACGGCTTGTAAAAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTAGGTCTGAGGCCTTGCGACAAGCACAATTAAAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTTGGTAAAAGGATTGACCGTTCCTGTGTTCACAAAGGTTGCAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CCTGAAAAAATAGGCGGATTTGTAGATACGCTTATTCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACATCCGCCGTCGGAGTTTACCTGCCCGTGCACCGAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATAAACCCAGTTGAGATTGGCCGCCATGCGCACCTCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGTCGTCCTGCCAGTCTCCCGCCACCAGCGGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGGGCTTTGCCTGGAGCGCCCGGCGCAACACGGTGGT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCAGGTCCACGACCCGAACCCCTCGCCTGTGCGTCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACTGTTTGAGTATCAATGAGGACATTTTAAAACAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACAAAATCACCAGCGAGCTGGAAACCCGCAATGCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGAGTATTACGACGCGCTGGCCGCCAGCTTCCTCGGCGAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TATCTTTTTTGGATTGTAAATCTATATCAAGATTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTCCTCATCGGATTCCCCACGCACGTCTACTGTTTCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCTGGTTACCGGCAAGCGCTTGTTTATGCGGCAGTTGGCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGCTTACTTCAAGAAAGAGAACTCGGACCTCAGGCCACTTCAGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CAAAAAGGTTTGGCAGAACCTAAGTCAAGAACATCAGAATGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGATAGAAGCGAGTTTCAGCCGAGGAACGCCGGGTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGCCGACCACTATAACGCGATGGTCATGTTCGTCAAACTACG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGCCCGTGTAGAGCGAGGCTGCGTCGGTCTGCTCTTCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTAGTGTAATAGCGCTCGATTTTAGTGATTGGCTTTTCAATTAT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAATTCCAAAACATCAAAGCTAAGATAGAGACCGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACTTTCACCATCGAATCCGGTGACACCCACCAGGGTTCCACC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACAACCCCCATATCTTCAAACTCGGACGGTTCAAAGTCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCAGCTCTCATAGCAGTGCTAAGCCCTTTAACTGCTTC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCCGATGCTACAAAAATTGCCAATCGTGCCGAAAGCAAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTTCATCGCCCATGAAAACCACTATCGACTGGATGCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCGGTTTCCCCATTTCCAGCGTCAACAGTTGACCAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCACCAATGCGGTCGGCATGGCACTCGCTGAAAAGCTACTCGCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGCGGGGCTTGCCGTCGCGATATTTCCAACTTGGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCGCGAAGGTGAACGGCGCGCGCGGCGACGCGGCGGGGCTCGCCCGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGTATCCGGCTCACGCAACGAGAGCGCTCTTCATG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCTATTTACTTACTTATATAAGTAAGTAATTAATTTATATCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGATCGTCTTTATAGGCTGAATTGTTTTGCTCAGGCGTGTGTCCCAGCGATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TGGGCGCGCAATGCCTCTGTATTGCAAAAGTTGCCTTAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAAGTTGGCCGAGTCGCAGAAAAAATCGGCGCGGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GATGGGCAACTGGGTCTTCGGGTGTGACATCTGCCAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACTCCAATGTGGTTTTTACCTCTTGTTCCACACTGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CTGAGTTGCATGCAGAGCCATAAGGGCATCGAGCTGAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTGGTATCTTCGCAACCCTACTCGACACACCGTAGTTCTTTGTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGGATAAAAATATTCGTTACCTTTTGCAGCTCCGCCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TAAACCACGTAAAATTATTTCCACCCAAGACAATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTGGTAGCTCTAACATTACATGGATAATGGTTTGTATCCGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTTCGGGTCAGGTGGGCTGGTTGAGCTTCTTAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA


>NC_019689|5|5|2419748-2423389|CRISPRCasFinder
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCAAGGGCACGACCGGCGAGGCGCGGCTAGGCAAC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GCCGGCCAGGGCCTCGGCCACGGTGCGCGCGGCCT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AAAACCCAGTTTTTGCGAGTTAACGGCTTGTAAAAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TAGGTCTGAGGCCTTGCGACAAGCACAATTAAAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGGTAAAAGGATTGACCGTTCCTGTGTTCACAAAGGTTGCAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CCTGAAAAAATAGGCGGATTTGTAGATACGCTTATTCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACATCCGCCGTCGGAGTTTACCTGCCCGTGCACCGAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATAAACCCAGTTGAGATTGGCCGCCATGCGCACCTCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGTCGTCCTGCCAGTCTCCCGCCACCAGCGGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGGGCTTTGCCTGGAGCGCCCGGCGCAACACGGTGGT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCAGGTCCACGACCCGAACCCCTCGCCTGTGCGTCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACTGTTTGAGTATCAATGAGGACATTTTAAAACAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACAAAATCACCAGCGAGCTGGAAACCCGCAATGCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGAGTATTACGACGCGCTGGCCGCCAGCTTCCTCGGCGAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TATCTTTTTTGGATTGTAAATCTATATCAAGATTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTCCTCATCGGATTCCCCACGCACGTCTACTGTTTCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCTGGTTACCGGCAAGCGCTTGTTTATGCGGCAGTTGGCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGCTTACTTCAAGAAAGAGAACTCGGACCTCAGGCCACTTCAGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CAAAAAGGTTTGGCAGAACCTAAGTCAAGAACATCAGAATGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGATAGAAGCGAGTTTCAGCCGAGGAACGCCGGGTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGCCGACCACTATAACGCGATGGTCATGTTCGTCAAACTACG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GCCCGTGTAGAGCGAGGCTGCGTCGGTCTGCTCTT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTAGTGTAATAGCGCTCGATTTTAGTGATTGGCTTTTCAATTAT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAATTCCAAAACATCAAAGCTAAGATAGAGACCGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACTTTCACCATCGAATCCGGTGACACCCACCAGGGTTCCACC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACAACCCCCATATCTTCAAACTCGGACGGTTCAAAGTCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCAGCTCTCATAGCAGTGCTAAGCCCTTTAACTGCTTC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCCGATGCTACAAAAATTGCCAATCGTGCCGAAAGCAAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTTCATCGCCCATGAAAACCACTATCGACTGGATGCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCGGTTTCCCCATTTCCAGCGTCAACAGTTGACCAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCACCAATGCGGTCGGCATGGCACTCGCTGAAAAGCTACTCGCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGCGGGGCTTGCCGTCGCGATATTTCCAACTTGGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCGCGAAGGTGAACGGCGCGCGCGGCGACGCGGCGGGGCTCGCCCGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGTATCCGGCTCACGCAACGAGAGCGCTCTTCATG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CTATTTACTTACTTATATAAGTAAGTAATTAATTTATAT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGATCGTCTTTATAGGCTGAATTGTTTTGCTCAGGCGTGTGTCCCAGCGATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TGGGCGCGCAATGCCTCTGTATTGCAAAAGTTGCCTTAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAAGTTGGCCGAGTCGCAGAAAAAATCGGCGCGGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GATGGGCAACTGGGTCTTCGGGTGTGACATCTGCCAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACTCCAATGTGGTTTTTACCTCTTGTTCCACACTGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CTGAGTTGCATGCAGAGCCATAAGGGCATCGAGCTGAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTGGTATCTTCGCAACCCTACTCGACACACCGTAGTTCTTTGTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGGATAAAAATATTCGTTACCTTTTGCAGCTCCGCCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TAAACCACGTAAAATTATTTCCACCCAAGACAATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTGGTAGCTCTAACATTACATGGATAATGGTTTGTATCCGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTTCGGGTCAGGTGGGCTGGTTGAGCTTCTTAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC

>NC_019689|5|3|2419748-2423389|CRT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCAAGGGCACGACCGGCGAGGCGCGGCTAGGCAAC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GCCGGCCAGGGCCTCGGCCACGGTGCGCGCGGCCT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AAAACCCAGTTTTTGCGAGTTAACGGCTTGTAAAAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TAGGTCTGAGGCCTTGCGACAAGCACAATTAAAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGGTAAAAGGATTGACCGTTCCTGTGTTCACAAAGGTTGCAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CCTGAAAAAATAGGCGGATTTGTAGATACGCTTATTCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACATCCGCCGTCGGAGTTTACCTGCCCGTGCACCGAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATAAACCCAGTTGAGATTGGCCGCCATGCGCACCTCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGTCGTCCTGCCAGTCTCCCGCCACCAGCGGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGGGCTTTGCCTGGAGCGCCCGGCGCAACACGGTGGT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCAGGTCCACGACCCGAACCCCTCGCCTGTGCGTCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACTGTTTGAGTATCAATGAGGACATTTTAAAACAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACAAAATCACCAGCGAGCTGGAAACCCGCAATGCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGAGTATTACGACGCGCTGGCCGCCAGCTTCCTCGGCGAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TATCTTTTTTGGATTGTAAATCTATATCAAGATTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTCCTCATCGGATTCCCCACGCACGTCTACTGTTTCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCTGGTTACCGGCAAGCGCTTGTTTATGCGGCAGTTGGCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGCTTACTTCAAGAAAGAGAACTCGGACCTCAGGCCACTTCAGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CAAAAAGGTTTGGCAGAACCTAAGTCAAGAACATCAGAATGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGATAGAAGCGAGTTTCAGCCGAGGAACGCCGGGTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGCCGACCACTATAACGCGATGGTCATGTTCGTCAAACTACG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GCCCGTGTAGAGCGAGGCTGCGTCGGTCTGCTCTT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTAGTGTAATAGCGCTCGATTTTAGTGATTGGCTTTTCAATTAT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAATTCCAAAACATCAAAGCTAAGATAGAGACCGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACTTTCACCATCGAATCCGGTGACACCCACCAGGGTTCCACC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACAACCCCCATATCTTCAAACTCGGACGGTTCAAAGTCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCAGCTCTCATAGCAGTGCTAAGCCCTTTAACTGCTTC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCCGATGCTACAAAAATTGCCAATCGTGCCGAAAGCAAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTTCATCGCCCATGAAAACCACTATCGACTGGATGCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCGGTTTCCCCATTTCCAGCGTCAACAGTTGACCAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCACCAATGCGGTCGGCATGGCACTCGCTGAAAAGCTACTCGCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGCGGGGCTTGCCGTCGCGATATTTCCAACTTGGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCGCGAAGGTGAACGGCGCGCGCGGCGACGCGGCGGGGCTCGCCCGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGTATCCGGCTCACGCAACGAGAGCGCTCTTCATG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CTATTTACTTACTTATATAAGTAAGTAATTAATTTATAT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGATCGTCTTTATAGGCTGAATTGTTTTGCTCAGGCGTGTGTCCCAGCGATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TGGGCGCGCAATGCCTCTGTATTGCAAAAGTTGCCTTAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAAGTTGGCCGAGTCGCAGAAAAAATCGGCGCGGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GATGGGCAACTGGGTCTTCGGGTGTGACATCTGCCAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACTCCAATGTGGTTTTTACCTCTTGTTCCACACTGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CTGAGTTGCATGCAGAGCCATAAGGGCATCGAGCTGAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTGGTATCTTCGCAACCCTACTCGACACACCGTAGTTCTTTGTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGGATAAAAATATTCGTTACCTTTTGCAGCTCCGCCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TAAACCACGTAAAATTATTTCCACCCAAGACAATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTGGTAGCTCTAACATTACATGGATAATGGTTTGTATCCGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTTCGGGTCAGGTGGGCTGGTTGAGCTTCTTAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC

>NC_019689|5|3|2420113-2421344|PILER-CR
	TCAAGGGCACGACCGGCGAGGCGCGGCTAGGCAAC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GCCGGCCAGGGCCTCGGCCACGGTGCGCGCGGCCT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AAAACCCAGTTTTTGCGAGTTAACGGCTTGTAAAAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTAGGTCTGAGGCCTTGCGACAAGCACAATTAAAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTTGGTAAAAGGATTGACCGTTCCTGTGTTCACAAAGGTTGCAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CCTGAAAAAATAGGCGGATTTGTAGATACGCTTATTCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACATCCGCCGTCGGAGTTTACCTGCCCGTGCACCGAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATAAACCCAGTTGAGATTGGCCGCCATGCGCACCTCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGTCGTCCTGCCAGTCTCCCGCCACCAGCGGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGGGCTTTGCCTGGAGCGCCCGGCGCAACACGGTGGT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCAGGTCCACGACCCGAACCCCTCGCCTGTGCGTCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACTGTTTGAGTATCAATGAGGACATTTTAAAACAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACAAAATCACCAGCGAGCTGGAAACCCGCAATGCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGAGTATTACGACGCGCTGGCCGCCAGCTTCCTCGGCGAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TATCTTTTTTGGATTGTAAATCTATATCAAGATTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTCCTCATCGGATTCCCCACGCACGTCTACTGTTTCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCTGGTTACCGGCAAGCGCTTGTTTATGCGGCAGTTGGCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGCTTACTTCAAGAAAGAGAACTCGGACCTCAGGCCACTTCAGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CAAAAAGGTTTGGCAGAACCTAAGTCAAGAACATCAGAATGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGATAGAAGCGAGTTTCAGCCGAGGAACGCCGGGTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGCCGACCACTATAACGCGATGGTCATGTTCGTCAAACTACG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGCCCGTGTAGAGCGAGGCTGCGTCGGTCTGCTCTTCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTAGTGTAATAGCGCTCGATTTTAGTGATTGGCTTTTCAATTAT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAATTCCAAAACATCAAAGCTAAGATAGAGACCGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACTTTCACCATCGAATCCGGTGACACCCACCAGGGTTCCACC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACAACCCCCATATCTTCAAACTCGGACGGTTCAAAGTCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCAGCTCTCATAGCAGTGCTAAGCCCTTTAACTGCTTC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCCGATGCTACAAAAATTGCCAATCGTGCCGAAAGCAAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTTCATCGCCCATGAAAACCACTATCGACTGGATGCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCGGTTTCCCCATTTCCAGCGTCAACAGTTGACCAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCACCAATGCGGTCGGCATGGCACTCGCTGAAAAGCTACTCGCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGCGGGGCTTGCCGTCGCGATATTTCCAACTTGGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCGCGAAGGTGAACGGCGCGCGCGGCGACGCGGCGGGGCTCGCCCGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGTATCCGGCTCACGCAACGAGAGCGCTCTTCATG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCTATTTACTTACTTATATAAGTAAGTAATTAATTTATATCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGATCGTCTTTATAGGCTGAATTGTTTTGCTCAGGCGTGTGTCCCAGCGATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TGGGCGCGCAATGCCTCTGTATTGCAAAAGTTGCCTTAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAAGTTGGCCGAGTCGCAGAAAAAATCGGCGCGGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GATGGGCAACTGGGTCTTCGGGTGTGACATCTGCCAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACTCCAATGTGGTTTTTACCTCTTGTTCCACACTGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CTGAGTTGCATGCAGAGCCATAAGGGCATCGAGCTGAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTGGTATCTTCGCAACCCTACTCGACACACCGTAGTTCTTTGTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGGATAAAAATATTCGTTACCTTTTGCAGCTCCGCCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TAAACCACGTAAAATTATTTCCACCCAAGACAATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTGGTAGCTCTAACATTACATGGATAATGGTTTGTATCCGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTTCGGGTCAGGTGGGCTGGTTGAGCTTCTTAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA


>NC_019689|5|4|2421380-2422333|PILER-CR
	TCAAGGGCACGACCGGCGAGGCGCGGCTAGGCAAC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GCCGGCCAGGGCCTCGGCCACGGTGCGCGCGGCCT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AAAACCCAGTTTTTGCGAGTTAACGGCTTGTAAAAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTAGGTCTGAGGCCTTGCGACAAGCACAATTAAAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTTGGTAAAAGGATTGACCGTTCCTGTGTTCACAAAGGTTGCAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CCTGAAAAAATAGGCGGATTTGTAGATACGCTTATTCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACATCCGCCGTCGGAGTTTACCTGCCCGTGCACCGAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATAAACCCAGTTGAGATTGGCCGCCATGCGCACCTCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGTCGTCCTGCCAGTCTCCCGCCACCAGCGGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGGGCTTTGCCTGGAGCGCCCGGCGCAACACGGTGGT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCAGGTCCACGACCCGAACCCCTCGCCTGTGCGTCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACTGTTTGAGTATCAATGAGGACATTTTAAAACAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACAAAATCACCAGCGAGCTGGAAACCCGCAATGCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGAGTATTACGACGCGCTGGCCGCCAGCTTCCTCGGCGAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TATCTTTTTTGGATTGTAAATCTATATCAAGATTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTCCTCATCGGATTCCCCACGCACGTCTACTGTTTCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCTGGTTACCGGCAAGCGCTTGTTTATGCGGCAGTTGGCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGCTTACTTCAAGAAAGAGAACTCGGACCTCAGGCCACTTCAGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CAAAAAGGTTTGGCAGAACCTAAGTCAAGAACATCAGAATGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGATAGAAGCGAGTTTCAGCCGAGGAACGCCGGGTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGCCGACCACTATAACGCGATGGTCATGTTCGTCAAACTACG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGCCCGTGTAGAGCGAGGCTGCGTCGGTCTGCTCTTCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTAGTGTAATAGCGCTCGATTTTAGTGATTGGCTTTTCAATTAT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAATTCCAAAACATCAAAGCTAAGATAGAGACCGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACTTTCACCATCGAATCCGGTGACACCCACCAGGGTTCCACC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACAACCCCCATATCTTCAAACTCGGACGGTTCAAAGTCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCAGCTCTCATAGCAGTGCTAAGCCCTTTAACTGCTTC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCCGATGCTACAAAAATTGCCAATCGTGCCGAAAGCAAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTTCATCGCCCATGAAAACCACTATCGACTGGATGCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCGGTTTCCCCATTTCCAGCGTCAACAGTTGACCAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCACCAATGCGGTCGGCATGGCACTCGCTGAAAAGCTACTCGCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGCGGGGCTTGCCGTCGCGATATTTCCAACTTGGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCGCGAAGGTGAACGGCGCGCGCGGCGACGCGGCGGGGCTCGCCCGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGTATCCGGCTCACGCAACGAGAGCGCTCTTCATG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCTATTTACTTACTTATATAAGTAAGTAATTAATTTATATCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGATCGTCTTTATAGGCTGAATTGTTTTGCTCAGGCGTGTGTCCCAGCGATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TGGGCGCGCAATGCCTCTGTATTGCAAAAGTTGCCTTAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAAGTTGGCCGAGTCGCAGAAAAAATCGGCGCGGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GATGGGCAACTGGGTCTTCGGGTGTGACATCTGCCAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACTCCAATGTGGTTTTTACCTCTTGTTCCACACTGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CTGAGTTGCATGCAGAGCCATAAGGGCATCGAGCTGAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTGGTATCTTCGCAACCCTACTCGACACACCGTAGTTCTTTGTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGGATAAAAATATTCGTTACCTTTTGCAGCTCCGCCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TAAACCACGTAAAATTATTTCCACCCAAGACAATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTGGTAGCTCTAACATTACATGGATAATGGTTTGTATCCGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTTCGGGTCAGGTGGGCTGGTTGAGCTTCTTAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA


>NC_019689|5|5|2422373-2423389|PILER-CR
	TCAAGGGCACGACCGGCGAGGCGCGGCTAGGCAAC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GCCGGCCAGGGCCTCGGCCACGGTGCGCGCGGCCT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AAAACCCAGTTTTTGCGAGTTAACGGCTTGTAAAAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTAGGTCTGAGGCCTTGCGACAAGCACAATTAAAACTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACTTGGTAAAAGGATTGACCGTTCCTGTGTTCACAAAGGTTGCAGCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CCTGAAAAAATAGGCGGATTTGTAGATACGCTTATTCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACATCCGCCGTCGGAGTTTACCTGCCCGTGCACCGAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATAAACCCAGTTGAGATTGGCCGCCATGCGCACCTCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGTCGTCCTGCCAGTCTCCCGCCACCAGCGGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGGGCTTTGCCTGGAGCGCCCGGCGCAACACGGTGGT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCAGGTCCACGACCCGAACCCCTCGCCTGTGCGTCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACTGTTTGAGTATCAATGAGGACATTTTAAAACAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACAAAATCACCAGCGAGCTGGAAACCCGCAATGCA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGAGTATTACGACGCGCTGGCCGCCAGCTTCCTCGGCGAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TATCTTTTTTGGATTGTAAATCTATATCAAGATTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTCCTCATCGGATTCCCCACGCACGTCTACTGTTTCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCTGGTTACCGGCAAGCGCTTGTTTATGCGGCAGTTGGCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GGCTTACTTCAAGAAAGAGAACTCGGACCTCAGGCCACTTCAGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CAAAAAGGTTTGGCAGAACCTAAGTCAAGAACATCAGAATGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CGATAGAAGCGAGTTTCAGCCGAGGAACGCCGGGTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGCCGACCACTATAACGCGATGGTCATGTTCGTCAAACTACG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACGCCCGTGTAGAGCGAGGCTGCGTCGGTCTGCTCTTCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTAGTGTAATAGCGCTCGATTTTAGTGATTGGCTTTTCAATTAT
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAATTCCAAAACATCAAAGCTAAGATAGAGACCGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACTTTCACCATCGAATCCGGTGACACCCACCAGGGTTCCACC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GACAACCCCCATATCTTCAAACTCGGACGGTTCAAAGTCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCAGCTCTCATAGCAGTGCTAAGCCCTTTAACTGCTTC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCTCCGATGCTACAAAAATTGCCAATCGTGCCGAAAGCAAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTTCATCGCCCATGAAAACCACTATCGACTGGATGCGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ATCGGTTTCCCCATTTCCAGCGTCAACAGTTGACCAAAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCACCAATGCGGTCGGCATGGCACTCGCTGAAAAGCTACTCGCCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTCGCGGGGCTTGCCGTCGCGATATTTCCAACTTGGC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TCGCGAAGGTGAACGGCGCGCGCGGCGACGCGGCGGGGCTCGCCCGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AGTATCCGGCTCACGCAACGAGAGCGCTCTTCATG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAACCTATTTACTTACTTATATAAGTAAGTAATTAATTTATATCTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGATCGTCTTTATAGGCTGAATTGTTTTGCTCAGGCGTGTGTCCCAGCGATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TGGGCGCGCAATGCCTCTGTATTGCAAAAGTTGCCTTAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CACAAGTTGGCCGAGTCGCAGAAAAAATCGGCGCGGA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GATGGGCAACTGGGTCTTCGGGTGTGACATCTGCCAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACTCCAATGTGGTTTTTACCTCTTGTTCCACACTGG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	CTGAGTTGCATGCAGAGCCATAAGGGCATCGAGCTGAG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTGGTATCTTCGCAACCCTACTCGACACACCGTAGTTCTTTGTAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TTGGATAAAAATATTCGTTACCTTTTGCAGCTCCGCCAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	TAAACCACGTAAAATTATTTCCACCCAAGACAATTG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	GTGGTAGCTCTAACATTACATGGATAATGGTTTGTATCCGCG
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	ACCTTCGGGTCAGGTGGGCTGGTTGAGCTTCTTAAGCC
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC	AACCGAAGCCAGCTCTTGAGGTTCCATGCCAACAA
CTCTCTATTTATTAGAGAAATTAGTTGAATGGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015143869.1\|2418272_2419265_+\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|376633
NC_019689.1\|WP_015143867.1\|2416434_2417676_-\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_019689.1\|WP_015143878.1\|2435811_2437425_-\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|234864
NC_019689.1\|WP_015143877.1\|2434259_2435771_-\|threonine-ammonia-lyase,-biosynthetic	unknown	unknown	gnl\|CDD\|236417
NC_019689.1\|WP_015143863.1\|2410709_2411498_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NC_019689.1\|WP_015143876.1\|2431350_2434230_+\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|215452
NC_019689.1\|WP_041393148.1\|2412781_2413141_-\|four-helix-bundle-protein	unknown	unknown	gnl\|CDD\|274132
NC_019689.1\|WP_015143861.1\|2408121_2410110_-\|hypothetical-protein	csm3gr7	pfam03787_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187792
NC_019689.1\|WP_015143860.1\|2406757_2408038_-\|hypothetical-protein	csx1	mkCas0109_csx1_CAS-III	gnl\|CDD\|312974
NC_019689.1\|WP_015143875.1\|2428780_2431021_-\|DUF839-domain-containing-protein	unknown	unknown	gnl\|CDD\|225752
NC_019689.1\|WP_015143880.1\|2438204_2439041_-\|sulfurtransferase	unknown	unknown	gnl\|CDD\|225450
NC_019689.1\|WP_041393150.1\|2439113_2439554_-\|anti-sigma-regulatory-factor	unknown	unknown	gnl\|CDD\|379279
NC_019689.1\|WP_015143873.1\|2425627_2426185_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NC_019689.1\|WP_015143871.1\|2423445_2424228_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|100107
NC_019689.1\|WP_015143862.1\|2410213_2410609_-\|hypothetical-protein	cmr5gr11	cls000022_cmr5gr11_CAS-III-B	unknown
NC_019689.1\|WP_015143874.1\|2426278_2428231_-\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NC_019689.1\|WP_015143870.1\|2419273_2419552_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_019689.1\|WP_015143868.1\|2417966_2418254_+\|hypothetical-protein	csx18	cls000006_csx18_CAS-I:CAS-III	unknown
NC_019689.1\|WP_015143879.1\|2437522_2438062_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350235
NC_019689.1\|WP_015143864.1\|2411514_2412696_-\|CRISPR-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl\|CDD\|187879

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015143869.1\|2418272_2419265_+\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	8.02094e-111
NC_019689.1\|WP_015143867.1\|2416434_2417676_-\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	8.21929e-11
NC_019689.1\|WP_015143878.1\|2435811_2437425_-\|2-isopropylmalate-synthase	gnl\|CDD\|234864	PRK00915, PRK00915, 2-isopropylmalate synthase; Validated.	0
NC_019689.1\|WP_015143877.1\|2434259_2435771_-\|threonine-ammonia-lyase,-biosynthetic	gnl\|CDD\|236417	PRK09224, PRK09224, threonine ammonia-lyase IlvA.	0
NC_019689.1\|WP_015143876.1\|2431350_2434230_+\|isoleucine--tRNA-ligase	gnl\|CDD\|215452	PLN02843, PLN02843, isoleucyl-tRNA synthetase.	0
NC_019689.1\|WP_041393148.1\|2412781_2413141_-\|four-helix-bundle-protein	gnl\|CDD\|274132	TIGR02436, S23_ribosomal_protein, four helix bundle protein. This family describes a protein of unknown function whose structure is a bundle of four long alpha helices. Some of the first members of this family were found encoded in the (atypically large) intervening sequence (IVS) of Leptospira 23S RNA, a region often present in the rRNA gene and removed during rRNA processing without re-ligation. However, this location is not conserved, and naming this protein as a 23S RNA protein is both confusing and inaccurate.	1.86282e-25
NC_019689.1\|WP_015143861.1\|2408121_2410110_-\|hypothetical-protein	gnl\|CDD\|187792	cd09661, Cmr6_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	3.08794e-13
NC_019689.1\|WP_015143860.1\|2406757_2408038_-\|hypothetical-protein	gnl\|CDD\|312974	pfam09659, Cas_Csm6, CRISPR-associated protein (Cas_Csm6). Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	2.21563e-08
NC_019689.1\|WP_015143875.1\|2428780_2431021_-\|DUF839-domain-containing-protein	gnl\|CDD\|225752	COG3211, PhoX, Predicted phosphatase [General function prediction only].	5.68878e-107
NC_019689.1\|WP_015143880.1\|2438204_2439041_-\|sulfurtransferase	gnl\|CDD\|225450	COG2897, SseA, Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism].	2.79251e-89
NC_019689.1\|WP_015143873.1\|2425627_2426185_-\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	5.04657e-35
NC_019689.1\|WP_015143871.1\|2423445_2424228_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|100107	cd02440, AdoMet_MTases, S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).	0.000183701
NC_019689.1\|WP_015143864.1\|2411514_2412696_-\|CRISPR-associated-protein-Cmr3	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	2.10555e-69
NC_019689.1\|WP_015143874.1\|2426278_2428231_-\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_019689.1\|WP_015143870.1\|2419273_2419552_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.09222e-35
NC_019689.1\|WP_041393150.1\|2439113_2439554_-\|anti-sigma-regulatory-factor	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	7.77037e-22
NC_019689.1\|WP_015143879.1\|2437522_2438062_-\|NYN-domain-containing-protein	gnl\|CDD\|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.02602e-56
NC_019689.1\|WP_015143863.1\|2410709_2411498_-\|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	1.19242e-37

>NC_019689.1|WP_015143870.1|2419273_2419552_+|CRISPR-associated-endonuclease-Cas2
MLFYVVVYDLPCDKRRKKVADLLEGYGQRVQYSVFECILTKAKYDELRQRLKKRIKEEEDSVRFYPLSGHTLAQVEIWGQPPLTKPPSSLIV
>NC_019689.1|WP_015143869.1|2418272_2419265_+|CRISPR-associated-endonuclease-Cas1
MKSLYVSQQGCYVSLKQESLIVQQKGKILAEVQLPLLEQILIFGKSQVTTQAIRTCLWRNIPIAYLSRMGYCYGRLLPLERGYRHLTRYQQQISSLERLLVAREIVRAKLKNSRVILLRQQRRHNSETIAFAIQSLEHLIQKATQADNLERLMGYEGAGSGSYFSAFGESLTNREFVFLARSRRPPGNPVNALLSFGYQVLWNHLLALIEIQGLDPYQACLHQGTERHAALASDLIEEFRAPIVDSLVLWLVNSKVMDAANDFEYGNGGCYLNNSGRKKYLKAFLQRMEEEVQTNSQQKQPRWDLLAQQVKLFKQFIYEPSRGYQPFLIR
>NC_019689.1|WP_015143868.1|2417966_2418254_+|hypothetical-protein
MYLSLRATFVRNVVVAGVNGAITLILLLIAPLGLAAVIVNTVMVTASTFVVCTLGDLVVAWLLKSSSPNQLTRGGELRQFNPFSQPKAIDRRKRY
>NC_019689.1|WP_015143867.1|2416434_2417676_-|WYL-domain-containing-protein
MAKQAKSHPYADPQAFDRLMLLIATLVNYPGVGYRENDRAEISEPGNHHNALEALKNQLRELAAAVGFQLPEGYPATPTLRRDLEKLRDYYILDRRMYRWGYYLGTGVMDRDEFRVAFNALESQAIYQGDPRIRQIYRQLRKRLRGFEFNEVQTSAVRWGKDYPRKDFFYPVRQHLNRAINYTDPQEMMEKGEFRNTLFHQIDKVERAIVEGQAIEISRSFDLYGHQKVGPLVIWPLQLIYYDIAWYLLYESCSNGCLAIARVNRFSNYCQILTPGGRGIEAQKQSLKRAYRLLKNGWGFKLGELEEQQLELRGELEFVRVKVRFFPPVSSFIEEGELRHSHQKIRRGPKDSQTGKPQYVDYCLELPPRSLDEFSIWVQRYGDRAQVLSPPQLVEKHRQAALNLVDRYTKANN
>NC_019689.1|WP_041393148.1|2412781_2413141_-|four-helix-bundle-protein
MNGNKHDLRKRTKDFAIQIIILYSNLPKTTEASVMGKQILRSGTSVGAHYREATRARSTAEFISKIEGGLQELEETVYWLELLTETNTVNTAKTQNLFQEAEELMRILVASVKTAKRAN
>NC_019689.1|WP_015143864.1|2411514_2412696_-|CRISPR-associated-protein-Cmr3
MHWYTLTPLDILLFRDAKPFSPGERAWAGSVFPPNGHAIAGAIRGLLNSKDNLTIKGTFLCYQQQLYFPRPLNYVNNSLLHPLTWLDEKSPARQMIWDRLSPAPLLLKEKESGKGKEKENKLEQKPRHYLPFSVVTKLLNNEILNPEDWLCQQGESSQPWTVETRSHNAIAPDSRQVKDADGYFVENAIRLHSGWSMAIAIDRKIPNVPTSMRLGGEGHRVLVEECPSLGEQWEQLQQQSQRNYQRGGKSLAYLITPGVFERIHKNQKAVCQPYPWEWKLAHTVNSNQKPGNLVSVATAQPLPISGRVKDNAELGMMNDERNNSSFSTHPSSLKSIPAPQVFAAPAGSVYYLERPDTLFAENLNSQPGKALEKAKRWRQLGYSELLWISYQDN
>NC_019689.1|WP_015143863.1|2410709_2411498_-|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MINYAYLYLLSPLHTGGTTQEGNLLGIARESHTNFPYIPSSSIRGRLRASVEDKDQKFKLFGTDLENASQLEQGTIWIGDGSLLWLPVPSLSHGVVWVSCPMLLKRWARFTGKLNRIPVEYSCNFLNGNSAVYLKDAILKAEELKQWQDWQDFLPQTPQTNTIERAIVLPDKHCATLIQMSLWRQVKIKLDENKTVDGGFRYEEAIPPDTLMYFTWGTTSAANGTASQIHQEFSQLLAKHEILQIGGQESLGRGFVQQWLEK
>NC_019689.1|WP_015143862.1|2410213_2410609_-|hypothetical-protein
MQTFDPRTFSTPVYEALQELRNRNSNDNSRLKEQKSQAVELYTYLATWGMMRLKAEEQALSQKGKQDVVKKYFECLQLLSPVKDLAGNKGLDSLKQLKADDYLGLTGLGLNLAQEFSFWANAIYHDVKGDA
>NC_019689.1|WP_015143861.1|2408121_2410110_-|hypothetical-protein
MSPQPIQRPQRPITRPNRSQQSSNHNGGGNNDGHGNRRNNNGGNNNGGNNQPPSPWLNSDKPPRPDSTASFVEYLRWMREPEREYKDATKIQILQLAQENANYRDRLKQLNQRTELIAGKENTFTVKCPWRIRVGGHRGPESILLPAFDALGMPYIPASTLRGVARTQAIREIVAAEKIKWSAAEQKIAPYFGSIDTDNPQHSTGKVVFLDAYPLPSKTGGLSMDMANNIWKWDENRQPKYESNPNVFLSLQESSFLIGLRLASNCQDKEVLNKIKKWLIKGLQAGVGSQINTGYGQLILGDRDKSSSEFFRVKFAVEGQLIHAHQKFANIRQPFQTARDGNLKTDRNGNLKPATSAVPEVRPTAFKSMLRYWFRAFALGVLPVEQVMNWEGQIFGAITPKQQLGWVRVNIINGQLIQPEPKRNNERRGEQEGILTLSYSVAAPQDKSQAISSLFKNLTWMMFNLGGIGQGARRPCYSRQNRPYAPWFRGSTFFVDADLENPNSFWYAPESAKNFQKLFQTRLKTFYTALEQLIPNSNIAKNINSLLSFNNPSDRNWSDAADNHCRIVVCSGQEQYGKPHALAVLHGQDLKVTNSRGQLDYDGNLCGQTNKPVKPSPVWIADLEDYQVVTVFGATANPRSKYLHNLRQRSQQYYQIFPFTTN
>NC_019689.1|WP_015143860.1|2406757_2408038_-|hypothetical-protein
MTSIVLSFVGNQDPGTDKNDKEGSIVSLTNHLLEQNQEIKRVILLYTHGTQEAANFTKEWLLSSELPQLKIVEKNIELIPVDEKLSQDPIDLLLAIQAARQALERAKLYLNRGDFLELNASSGTPAMKSAWNILQAAGYAPQSRVWQVRNPDKMMPGQSRVFETNVNSLKKEFDLKVIREQINNYNYSGALANFKESGLKDNGVSVLLEYGRCRLACDFQKARQEIHQFRTIIDPRLSEEIDRLASHDQKYFVVELYFQALTKLKNQEYSNFLVLLFAFQESVLRFQVRKRLCPKLLNYPWKDVKEQVEKAIQQYQEGQLYSYLQNYRLPNGRSLQLNHPSRPVLLAILEYVSEQSSLLEPLKKINKYCDQRNDYVHQFEGVSFLEDQERLVRDIRKIVRQIAQIPEQNSFELLNQQLHSLLTSSL
>NC_019689.1|WP_015143871.1|2423445_2424228_-|class-I-SAM-dependent-methyltransferase
MEILDSYITSSPCEQNALNIFKNEWASRLPDQFAELAAGQIPLFEDGRIHWCVKSLGGIADQTILELGPLEAGHTYMLEKMGAASILSIEANTRAYLKCLIIKEILELKRAKFICGDFVKYLQNCSTKFDICLASGVLYHMTNPVELLSLISQVTNKVFIWTHYYDRDLLQANPHKIAKKFPSSISAEHNGFKHTLYRYEYLTALDDAGFCGGSQPFSNWMSRGDILACLKYLGFNEIEINFEQPDHPNGPSFSVLAIRN
>NC_019689.1|WP_015143873.1|2425627_2426185_-|universal-stress-protein
MTYSVNSQKVLTPQNQEGHSLTVGFKKILVAVDYLASTPELFEKALQLAKAYNSQLTIFHCLQEPIAGMPEFLAHAGMGAYSGVYSQEIIELEEQLIREATEELKAWLSSFVQKATEAGIKAESDYQPGEPGRQICATAKQWGADLIVIGRRGRSGLSELILGSVSNYVIHHAHCSVLVIQQQEK
>NC_019689.1|WP_015143874.1|2426278_2428231_-|ATP-dependent-zinc-metalloprotease-FtsH
MSIKNKPQIPSLGNLLLVLAGVSFLAYLFWPRSSRYPLQPYSQFLEQVEKGEVAVVMIGNDLIRYQLKASRSIGENPENLFQFPVDNPLQTTKTPNNPFHADASSSANNTSAEGEVLETIPLNDPQLPNKLREKGVVFAASPPPQNPWWMTLLAWVVPPLILVGAMHFLLNRGEERRSLAFSRSKAKVYVEGESARITFADIAGAEEAKTELVEIVEFLKNPERYNKIGARIPKGVLLVGPPGTGKTLLAKAVAGEAGVTFFSISASEFVELFVGTGAARVRDLFNQAKRQAPCIIFIDELDAIGKSRNSGGVASGSNDEREQTLNQLLTEMDGFAAGESTVIVLAATNRPETLDSALLRPGRFDRQVLVDRPDLLGRLAILEVYARKVELAEDVDLKAIAARTPGFAGADLANLINEAALLAARRQQEVVTQNELKEAIERVIAGLEKKSRVLNEKEKQIVAYHEVGHALVGAVMPGGGKVAKISIVPRGLSALGYTLKMPTEDRFLMSEAEFREQIATLLGGRASEELVFDSVTNGAADDLQRATDIAERMVTTYGMSKRLGPLAFDRAGQANFLGNGNGNLRRLVSEETAKAIDEEVKRIVEGEYQRAIAILDRNRELLDAIAQQLLKTEVIEGEELQAALERVRPL
>NC_019689.1|WP_015143875.1|2428780_2431021_-|DUF839-domain-containing-protein
MTIKRREFLYFLGASAGTIALGEPSKKVSLSFTTPTLAQTSPKTNSLQIEGLSFQPVKVPMPLDIDGMAEAEQISAYSTYEVVDDLVLPEGFTYDVIAAWGDRVGDSRFGYNNDYLSFIETSPNEGFLTVNFEYISGKTWMQTYPMVIGKSLPFDEVKAAAKDTQGEIDAFALPENDPLKAKILEISKEGLIDQGIGLISIRRNADGRWERTFSKSDRRITGISGLEDGRYLKATGPAVAIFNKSNKKGYDDKLGDKIIGTFQNCAGGTTPWGTVLSAEENFQDQVPEPVMADGSSLDPSETPFLITDEDLDGRANVLGLAGNKYGWMVEIDPANPDDYGTKHTWLGRYRHEAVAFRAVPGKPLAVYSGCDRRGGHLYKFISKETINDIKDKANSRLLEEGMLYGAKFNPDGTGRWIPLSPDTPINPVLPSQVAGEDGKGMVPLPNPDRLAGGIIKAISESEIAIFKERFKTLGDLYEGDPTEKQGAILIDAHYAANAAGITCTARPEDTEVAQDGTLFIAFTSGSPGSDGGSDKQIFKGSKGETPYEFGWIMRLQEDDSNPDSMTFRWELFATGGEPAEGGLGFSNPDNLEIDPDGNLWMVTDMSTSSQNKAVASRVVNGNPVSQIDLVGLFGNNSAWFIPTSGANAGTAYPFAISPMDTEICGLRFTEDRQTLFLAIQHPGEAGGIRQDLKTEIRQFDMRTTTGREFMQERKIPIGSNWPDKAANHPPRPAVVAVRRLNDRNWL
>NC_019689.1|WP_015143876.1|2431350_2434230_+|isoleucine--tRNA-ligase
MTEVKKLKDTVNLPKTKFDMRANAVKREPEIQKFWAENRIYETLSQNNPGEIFVLHDGPPYANGDLHMGHALNKILKDIINKYKLLRGYKVRYVPGWDCHGLPIELKVLQAMKSEEREGLTPLKLRRKARDFALKTQKEQCEGFKRYGVWGDWEHPYLTLTPDYEAAQIGVFGQMALKGYIYRGLKPVHWSPSSQTALAEAELEYPEGHTSRSIYVTFPITQAGEAAKEVLTPFIPNLGVAIWTTTPWTLPGNLAVALNPDLTYAVVEADSSLCQHRYLIVAKDLVERLSKTFGVNLTVKATILGKDLEHTTYRHPLYDRLGEILIGGDYVTTESGTGLVHTAPGHGQEDFIVGQRYGLPILSPVDDKGNFTAEAGQFAGLNVLKDANEAIVKELQEKGVLLKEEPYTHKYPYDWRTKKPTIFRATEQWFASVEGFRDEALKAIKSVKWIPAQGENRITPMVADRADWCISRQRSWGVPIPVFYDEETNEPLMTEETINHVREIIAQKGSDAWWELSVEELLPPTYRNNGRKYRKGMDTMDVWFDSGSSWAAVLKQREELKYPADMYLEGSDQHRGWFQSSLLTSVATNDIAPYKMVLTHGFVLDEQGRKMSKSLGNVVDPAVIIEGGKNQQQEPPYGADVLRLWVSSVDYSADVPLGPNLLKQLNDIRGKIRNTARFLLGNLYDFDPENHAVSYEQLPELDKYMLHRITEVFAEVTEAFETFQFFRFFQVVQNFCVVDLSNFYLDIAKDRLYISAPDSWRRRSCQTILAVAVENLAVAIAPVLCHLAEDIWQFLPYKTPYKSVFESGWVKTKDEWKKPELVDSWLKFRQIRNEVNKVMELARNGKSIGASLEAKVLLYVSDGELRKQLNSINPADSLSGNRVDELRYLFLASQVELVDSLEAIASADYKSESDLVSVGVVKADGQKCERCWNYSTRVGEFPEAPTICERCNAALAGEF
>NC_019689.1|WP_015143877.1|2434259_2435771_-|threonine-ammonia-lyase,-biosynthetic
MYCDYLVQILTARVYDVAQETPLEYAPNLSTRLNNKLLLKREDMQSVFSFKLRGAYNKMAQLPPERLAQGVIAASAGNHAQGVALGASVLGTRAIIVMPVTTPQVKVDAVKARGGEVVLYGDTYDDAYAYARQLSAEKGLTFIHPFDDPYVIAGQGTIGMEILRQYQKPIHAIFVAIGGGGLISGIAAYVKRLRPEIKIIGVEPVDADAMHQSLKAGKRVRLSQVGLFADGVAVREVGEETFRLCQQYVDDIILVGTDDTCAAIKDVFEDTRSILEPAGALAIAGAKAYVEREQIQEQTLIAVACGANMNFDRLRFVAERAELGERREAIFAVTIPEEPGSLRKFCECIGKRNLTEFNYRIADKQTAHIFVGVQIQNRADAVKIAATFEANGFKTLDLTDDELTKLHLRHMVGGHSPLAHHELLYRFEFPERPGALMKFVDSMSPDWNISLFHYRNNGADYGRIVVGIQVPPHEMEEWQAFLDTLGYRYWDESHNLAYKLFLG
>NC_019689.1|WP_015143878.1|2435811_2437425_-|2-isopropylmalate-synthase
MNNQPDRIIIFDTTLRDGEQSPGATLNVDEKLTIATALARLGVDIIEAGFPYASPGDFEAVQKIAEAVGVEGGPTICGLARATQQDIKAAAEALKPAAKKRIHTFLATSDIHLEYKLKKTRQEVLQIVPEMVAYAKSLVDDVEFSPEDAGRSDPEFLYQVLESAIAAGATTVNIPDTVGYLTPSEFGALIKGIKENVSNIDRAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAAMEELVMALHVRRQYFNPFLGRPADSTEPLTNINTKEIYRTSRLVSNLTGMMVQPNKAIVGANAFAHESGIHQDGVLKHKLTYEIMDAESIGLTNNQIVLGKLSGRNAFRTRLKELGFDLSETDLNKAFLRFKEVADKKKEITDWDLEAIVNDEINTAPELFRLELVQVSCGDNARPTATVALRTPDGKELMDAAIGTGPVDAVYKAINRVVNIPNELIEFSVKSVTAGIDAMGEVTIRLRHEGRIYSGHAANTDIIVASARAYISALNRLYAALQQKETAESEAPQEVVVS
>NC_019689.1|WP_015143879.1|2437522_2438062_-|NYN-domain-containing-protein
MTYFNNCTCQKKDRLSIFVDGNNMFYAQQKNGWFFDPRRVLEYFTSDPTVTLINAFWYTGLKDSQDQRGFRDALISLGYTVRYKILKEYYDDSSGRYSQKANLDIEIVVDMFNTVDQYDRVILFSGDGDFERAIELLRSKNTHITVVSTEGMIARELRNATDRYIDLNDIRDKIEKTDS
>NC_019689.1|WP_015143880.1|2438204_2439041_-|sulfurtransferase
MKKIQCVVSPQWLWERLHDPQHDPQVVVVDCRFQLANPQWGYQQYFASHVPGAYYLDLEKDLSAPPNKHGGRHPLPDRDLLAQKLASIGIVSGETLVVAYDDSRFAFAARLWWLLRYLGHDRVALLDGGWQGWIADGYPVCDAIPAPKSGNFAPNPQPDWIVDIETVRARKDSPSVVLLDSRDGDRYRGEREPIDPIAGHIPGAVNSPWQLVSNERGNLQPLSRQQQLWADYQQADEIIVYCGSGVTACVNLFSMELAGIRTAKLYPGGWSDWCSYLI
>NC_019689.1|WP_041393150.1|2439113_2439554_-|anti-sigma-regulatory-factor
MRSAFKVESALQALDLLLQHFDRLYQPWIPKKDWLQCQLALAEGFTNAVRHAHRNLPPETPIEVEIVLSQQSIEMRIWDRGSYFDLDGFLKNVALRNDRLSGHGQGLVILQKIASHLSYTRTNDDRNCLLIVKQFSSETPIAVNDP

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Crispr_ID: NC_019689_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_6

2610811-2610917

Orphan

Consensus_repeat	Method
CTTGTCCTTTCATTGTTGTCGCTCAGGCTCGTCTGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019689_6

>merge|NC_019689|6|2610811-2610917|CRISPRCasFinder
CTTGTCCTTTCATTGTTGTCGCTCAGGCTCGTCTGAGTCAAAGGCTTGTAGCGCAGTACCATAACAAGAACTTGTCCTTTCATTGTTGTCGCTCAGGCTCGTCTGAG

>NC_019689|6|6|2610811-2610917|CRISPRCasFinder
CTTGTCCTTTCATTGTTGTCGCTCAGGCTCGTCTGAG	TCAAAGGCTTGTAGCGCAGTACCATAACAAGAA
CTTGTCCTTTCATTGTTGTCGCTCAGGCTCGTCTGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015144030.1\|2621089_2621512_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NC_019689.1\|WP_186005315.1\|2597528_2597675_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_144266115.1\|2602396_2602495_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015144026.1\|2614669_2615494_-\|zinc-dependent-peptidase	unknown	unknown	gnl\|CDD\|377621
NC_019689.1\|WP_015144015.1\|2597759_2598218_-\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|176643
NC_019689.1\|WP_015144023.1\|2612087_2613299_-\|response-regulator	unknown	unknown	gnl\|CDD\|381129
NC_019689.1\|WP_015144024.1\|2613489_2613885_-\|pre-16S-rRNA-processing-nuclease-YqgF	unknown	unknown	gnl\|CDD\|128971
NC_019689.1\|WP_015144019.1\|2606038_2608762_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NC_019689.1\|WP_015144025.1\|2613964_2614282_-\|DUF1825-family-protein	unknown	unknown	gnl\|CDD\|370158
NC_019689.1\|WP_015144014.1\|2596910_2597468_+\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NC_019689.1\|WP_015144016.1\|2598458_2598998_-\|CheW-domain-containing-protein	unknown	unknown	gnl\|CDD\|214588
NC_019689.1\|WP_015144018.1\|2602459_2605939_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NC_019689.1\|WP_015144020.1\|2609871_2610621_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377333
NC_019689.1\|WP_015144027.1\|2615829_2617233_+\|3-isopropylmalate-dehydratase-large-subunit	unknown	unknown	gnl\|CDD\|235490
NC_019689.1\|WP_144266088.1\|2608785_2609852_-\|ISKra4-like-element-ISPle1-family-transposase	unknown	unknown	gnl\|CDD\|284250
NC_019689.1\|WP_015144029.1\|2618621_2620928_+\|PhoD-like-phosphatase	unknown	unknown	gnl\|CDD\|277335
NC_019689.1\|WP_015144022.1\|2611542_2611908_-\|response-regulator	unknown	unknown	gnl\|CDD\|381164
NC_019689.1\|WP_015144017.1\|2598994_2602363_-\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|223716
NC_019689.1\|WP_015144028.1\|2617234_2618239_-\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NC_019689.1\|WP_015144021.1\|2610946_2611492_-\|chemotaxis-protein-CheW	unknown	unknown	gnl\|CDD\|238374

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015144030.1\|2621089_2621512_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	7.56908e-22
NC_019689.1\|WP_015144026.1\|2614669_2615494_-\|zinc-dependent-peptidase	gnl\|CDD\|377621	pfam06167, Peptidase_M90, Glucose-regulated metallo-peptidase M90. MtfA (earlier known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E.coli. Mlc is a repressor of ptsG, and MtfA is found to bind and inactivate Mlc with high affinity. The membrane-bound protein EIICBGlc encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a glucose-regulated peptidase, whose activity is regulated by binding to Mlc available in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken up. A physiologically relevant target for this peptidase is not yet known.	4.27448e-128
NC_019689.1\|WP_015144015.1\|2597759_2598218_-\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	2.77985e-67
NC_019689.1\|WP_015144023.1\|2612087_2613299_-\|response-regulator	gnl\|CDD\|381129	cd17602, REC_PatA-like, phosphoacceptor receiver (REC) domain of PatA and similar domains. Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.	5.83455e-49
NC_019689.1\|WP_015144024.1\|2613489_2613885_-\|pre-16S-rRNA-processing-nuclease-YqgF	gnl\|CDD\|128971	smart00732, YqgFc, Likely ribonuclease with RNase H fold. YqgF proteins are likely to function as an alternative to RuvC in most bacteria, and could be the principal holliday junction resolvases in low-GC Gram-positive bacteria. In Spt6p orthologues, the catalytic residues are substituted indicating that they lack enzymatic functions.	1.02851e-16
NC_019689.1\|WP_015144019.1\|2606038_2608762_-\|GAF-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	8.43006e-75
NC_019689.1\|WP_015144025.1\|2613964_2614282_-\|DUF1825-family-protein	gnl\|CDD\|370158	pfam08855, DUF1825, Domain of unknown function (DUF1825). This uncharacterized family of proteins are principally found in cyanobacteria.	2.3824e-46
NC_019689.1\|WP_015144014.1\|2596910_2597468_+\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	5.43377e-45
NC_019689.1\|WP_015144016.1\|2598458_2598998_-\|CheW-domain-containing-protein	gnl\|CDD\|214588	smart00260, CheW, Two component signalling adaptor domain.	2.9133e-12
NC_019689.1\|WP_015144018.1\|2602459_2605939_-\|GAF-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	4.76543e-69
NC_019689.1\|WP_015144020.1\|2609871_2610621_-\|hypothetical-protein	gnl\|CDD\|377333	pfam04375, HemX, HemX, putative uroporphyrinogen-III C-methyltransferase. This is a family of bacterial putative uroporphyrinogen-III C-methyltransferase proteins. It forms one of the members of a complex of proteins involved in the biogenesis of the inner membrane in E.coli. Uroporphorphyrin-III C-methyltransferase (HemX) is a single spanning inner membrane protein that regulates the activity of NAD(P)H:glutamyl-tRNA reductase (HemA) in the tetrapyrrole biosynthesis pathway.	0.00908973
NC_019689.1\|WP_015144027.1\|2615829_2617233_+\|3-isopropylmalate-dehydratase-large-subunit	gnl\|CDD\|235490	PRK05478, PRK05478, 3-isopropylmalate dehydratase large subunit.	0
NC_019689.1\|WP_144266088.1\|2608785_2609852_-\|ISKra4-like-element-ISPle1-family-transposase	gnl\|CDD\|284250	pfam06782, UPF0236, Uncharacterized protein family (UPF0236).	1.70142e-05
NC_019689.1\|WP_015144029.1\|2618621_2620928_+\|PhoD-like-phosphatase	gnl\|CDD\|277335	cd07389, MPP_PhoD, Bacillus subtilis PhoD and related proteins, metallophosphatase domain. PhoD (also known as alkaline phosphatase D/APaseD in Bacillus subtilis) is a secreted phosphodiesterase encoded by phoD of the Pho regulon in Bacillus subtilis. PhoD homologs are found in prokaryotes, eukaryotes, and archaea. PhoD contains a twin arginine (RR) motif and is transported by the Tat (Twin-arginine translocation) translocation pathway machinery (TatAyCy). This family also includes the Fusarium oxysporum Fso1 protein. PhoD belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	0.00555871
NC_019689.1\|WP_015144022.1\|2611542_2611908_-\|response-regulator	gnl\|CDD\|381164	cd19937, REC_OmpR_BsPhoP-like, phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators. Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.92934e-35
NC_019689.1\|WP_015144017.1\|2598994_2602363_-\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|223716	COG0643, CheA, Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms].	3.63445e-148
NC_019689.1\|WP_015144028.1\|2617234_2618239_-\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	1.3195e-28
NC_019689.1\|WP_015144021.1\|2610946_2611492_-\|chemotaxis-protein-CheW	gnl\|CDD\|238374	cd00732, CheW, CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.	4.74225e-29

>NC_019689.1|WP_015144020.1|2609871_2610621_-|hypothetical-protein
MTQIPPKSDPKDFANSRLPEDDRAFLTDQTASGDELPTQAFYVESEAIADDKEPLLESEEAAIEPWEHQATPRKSGWGQKLNLKTKAAVLALAIGIIPAVAIGSIGYYAASQSETRQVFAAKKTQVDALSQVLTNFLAERYGDIQVMADLSVLADPRLRNTTSLQEKQARLEQYIKSYKVYESIVVIDMKGNPIVQAGSNDRPANFLEKKVDYYMEVLKTGRPAHSQRPSIGEHPVLEDLPFMGKCKGK
>NC_019689.1|WP_144266088.1|2608785_2609852_-|ISKra4-like-element-ISPle1-family-transposase
MNQEKQERIKACLQELSTLLYEEADKSKLTDLEGIEKTVRSQVLELVSPEIAPFFIEQKTGTKVGKTRKIKSLVGELKLKAKQLIRLGLKPRTRLSPLLQKCCLRLSANESYQKAEIEIEALTGVKVGHSTQQQLVLSQDFQLPLAKQSVSEVSVDGGKVRLRGKPKAGCHWRDYKTVRLQGIYYGAFFDDNQSLIDYVNSQQLLDPLVCLGDGHDGVWNLVREFGQDQFSRCEILDWYHLKENLYKVGGSLKRLKAAETLLWQGQVEAAKTLFNHCRGKQAKNFIAYLEKHLPRIVNYSYYQAEQLCSIGSGAVESAIKQIGLRIKISGAQWNVESVNHILSVRCAYLNGLLAV
>NC_019689.1|WP_015144019.1|2606038_2608762_-|GAF-domain-containing-protein
MLPSIVTGKYALFFAAPIKDSVTGQTIGVIRTLVPIKVVEDLIKPFTNEANKIHLVDKSGKVFLAPEGEQKLVGQSLDKEYPEFDPKLLTDRTGFTTLRDASRNSNVLLAYSNLQKRTNLPDFDWRILLSTPTSAAFAAQRQLLLTTLLGTGATAIAVGIIALLLADRLTRPIISAAEAVEKIGRGELDTRVAVSGEDELAALGANINVMAAQLETLVQEQAVSVEQAQLLKDITVKISQALDVDTIFRAAVEEIRKAIVSDRVIVYLFDKNWKGTVVAESVASGFPKSLGAQIADPCFAQNYVQKYKKGRVQATPDIYNAGLTDCHLAQLAPFSVRANLVAPIVASGELLGLLIAHQCSGTRNWQVGEIDFFTQAAIQVGAAIERTNLLQRQQIEAERAGVLRDITLELAQKVTKEEILAQPPLDKVRHALKSDRVILYQFDKTWKGTVTGESVAEEFPKALGAQIADPCFAKNYVEKYKRGHVQATPDIYNAGLTQCHLKQLEPFSVKANLVTPIVTSGDLLGLLIAHQCSGTRQWEEAEINFLAQVATQIGLALDRTNLLDKQRLSELAQRKEKEKLQQRALELLMQVDPLTQGDLTIRATVTEDEIGTIADSYNSTIENLRKIVSQVKEAAQKVALTTSNNDALVAALSQGAMQQTGEIAAALERIQAMTNSIRAVALSAEQAEEAVDQAAQTVEEGDAAMNRTVEGIMAIRQTVAETAKKVKRLGESTQKISKVVNLISSFADQTNLLALNASIEAAHAGEQGRGFAVVADEVRNLARQSAEATAEIEKVVAEIQAETNDVVAAMEEGTEQVVMGTKLVEETRQSLNRIAASSEQIGQLVEAIAKATEEQTEVSEVVSQSMTGIAAIANETSSSATDVSASFKELLAVAQALQESVGKFKVS
>NC_019689.1|WP_015144018.1|2602459_2605939_-|GAF-domain-containing-protein
MTQTPPKPNFKKIANDRSLISQSPQRETRTPSPQLVPSPSQIELLEAPKEGKANLWQNLSFRWKLSTLLIVGAALPTIGVTQGIVWYSQKTAQDTLKETVASNASGFQEDYIHWVRLESSGQVQAIADVLGASKIDLQNPAQVKANQMLLQSLIVPSKIEQERLDGWKSFRIIANAQGKTIAQFLRVHKDYSLGTAAEDRSEAIENVSLPTGIDLGNIAIVKESLRLKRPLKGIELLDRSVIQKLGLGEQFKASDANKGIKGLTAMAVEPIEVNGKVVGIAIAGVLLNRNNILVDTFREYYGSEASLYAGDLRVSTTIATADGKNRAIGDRAAEAVKKAVLDGGQRFPWREEIDGKPYLTYYLPLYDYRQDLNPQQAKPVGMLAVGTAPETLNSAVNSVRIVGYGIGLVFLLAAGAIAIPVAGTFSRPLRRLQDFARGIANGEKIAGLADTARRDEIGVLSQELDRMATKMEANLTALRQEKAREQLLKEVTLDLSQYPQVKNAFEIALEKLRIDLNVDRAFFYRFDEETFTGEVVAESVAQGLPRALGALITDPCFDNRMVEEYRRGRVQALANIYESGLADCHIKMLEAFAIRANLVVPIVCGSRGILTGLLSVNQCSESRVWQPSEIELLTQIATQFGLAIDRANLIEKTKIAAERAQALKDLTLKMSQSLESKKIFDTAVTEIRQAIRSDRVIIYQFDKNWKGTVVAESVADEFPKALGAEIADPCFADKYVQKYKQGRIQPTPDIYKAGLTECHLKQLEAFGIKANLVAPIVVGEDLLGLLIAHQCSAPRNWEPAEVDFLAQLATQVGLSLERASLLERQRQEKENLQRRALELLKEVDPVSQGDLTIRATVTEDEIGTVADSYNSTIESLRKIVGQVKMAAKQMTVTTSQNEVSVKTLSEEAVRQAQEIADALARIQSMTKSIREVTANAKQAEMVVQQASQTVRTGDVAMNRTVDGILAIRETVVETAEKVKRLGESTQKISKVIGLIGRFAAQTHMLALKASIEAARAGDEGQGFAVIADEVRILAAQSAEATAEISNLVTSIQTETNEVATAMQSGTERVAVGTKLVEETRQNLTKIAEASAQIDQLVRAIAKTANEQSQASETVSQTMNEVAAISTKTSAEATQVSNSFKELLTVAQTLQESVSKFKVE
>NC_019689.1|WP_144266115.1|2602396_2602495_+|hypothetical-protein
MRRNISILMSKSLNSDCKVKILFHLELTDALL
>NC_019689.1|WP_015144017.1|2598994_2602363_-|hybrid-sensor-histidine-kinase/response-regulator
MALNSDIRDQAYQFFIEEAPELLHSIESGLLTLREERSTAKVHEIMRAAHSLKGGAASVELNAIKTLSHRLEDAFKALYNETVEIDTELESLLLKAYDCLKNPLMEQIQVGSFDADAALQVAEPIFKQLEERLGDSLANADRYIPSSSDLGIDIVSSIFEVDVAQGLERLANVVANPQNYEVAGELRAQAEVFVGFAELLGLPGFGEIAQVALQALDRHPDKTLQITQLALADWQVSREQVLAGDRDRGGNPSEVLIALAQGSAGTAALLVHPEIVETQAEFDAQSLEAFWGETAPPALDDIFGTVTPAPETAPINFSTPSLDEVFGSVAPETTEASPSLDEVFGSVAPETTEASPSLDEVFGSVAPETTEASPMLYFTESKPEELAEKIDAAVQSVEQIFDRLPSIEETSEPSAPLSFPLPTSATPAPIAAKTNRETFTEPDKHPELPGVSAAKAASNLSVRVDFNRLERMNNLVGELSINRNSLSLQNEQIQGGVKELLARFARFQKMTGKLRELSDQMLVKPMNDELGDLKSDRDSTVASSQSSEFRIQSLAEFDALEMDSYGALYSLLQGLVEEMIQLEEAVEDIVLFARNSNQSLEQQRQMLTNLRDELMWARMLPLGEVLNRFPRTLRDLSTTYHKPVKLKLSGTGVLVDKAALEKLYDPLLHLLRNAFDHGIEPPEVRKQQGKSEEGQIEIRAFHQGNQTIIEIKDDGRGLNLEKIGQKAISVGLATPEELAMMTEDRIAELIFEPGFSTASQVSELSGRGVGLDVVRSQLRSLKGTVVVTSTPGKGTTFTLRLPLTLTISKLLVCLMNQEVTGQATAVALPSDSIEEIIIPTGEQIKKSGSQRFLHWQQQIIPIYRLNELLTYNCALPEITSSKVLSSVPTPDDWALPLLLLRRGQQLFALEVNRLVSEQELVIKPFGSAIASPSYTYGCTILGDGTLIPVINGGILLDQFLEPETAKAAIKSAFSDKQQIANAKSAPTVAQATTILVVDDSATLRRTLALTLQKAGYRVVQARDGREAIEQLQQTAGIQLVICDVEMPNMNGFEFLGQRRRDPEMTKIPVAMLTSRSSDKHRQLAMHLGASAYFTKPFIEQQFLAAIKDLLAQNSSKALTALR
>NC_019689.1|WP_015144016.1|2598458_2598998_-|CheW-domain-containing-protein
MNDLSNNQSPNIGLPIGQSQRSIKLLTFSVGKLNVALPVDLVKKVVNYTPIYGSGLSHLGVARIDDREITVVDLHKRLFNASQLIPSGSRGYLIIARNSVGESFGILVGQAPSLHDVPISQIRALPASYRRADTLEIASHVTVISHKEESLTVFILEVDRIVPPVSGIISASPQLSFPF
>NC_019689.1|WP_015144015.1|2597759_2598218_-|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MKLTSPAFAHEGKIPPKYTCDGENINPPLVISDVPAEAKSLVLIMDDPDVPKRLRADGMWDHWVVFNIAPSLTEIQEGKEPPGVHGIGTSKNLDYYGPCPPDREHRYFFKLYALDTRLNLPEKATKQQVERAMEGHILAKAELMGRYERIRN
>NC_019689.1|WP_186005315.1|2597528_2597675_-|hypothetical-protein
MATPLRGGNAKPGSEEEATKVRRKREAGDRFQLEKVTEGTLENQTEMI
>NC_019689.1|WP_015144014.1|2596910_2597468_+|DNA-starvation/stationary-phase-protection-protein
MSTAQGLLRAFGEVGDNPVLLDKSVTAPVCEGLNITLASFQALYLQYQKHHFIVEGSEFYQLHEFFQESYEAVQEHVHDLGERLNGLGGIPAASFAKLAELCCFSPEPDGAYDCRRMIEHDLEAEQALIQLIRRQAAQAESLGDRATRYLYEKILLETEERAYHLNHFLAPDSLTLAFVKNGSSH
>NC_019689.1|WP_015144021.1|2610946_2611492_-|chemotaxis-protein-CheW
MMSDAFLRDLGQTASGSGGRGREEQFLRFYLEPDTKVMLPVAQLTEVLTIPLGQIIPIPHMPAWVMGVYNWRGEILWMVDLGQLVGLTPWHQQSFKGSTYRAFVLKSAGKSETAAKSQTLGLVISRVDDIEWCDPAQIQSPPASAVEPGLAPFLRGFWVKPDGEILVALEGEAIMAAMPKS
>NC_019689.1|WP_015144022.1|2611542_2611908_-|response-regulator
MGTALVVDDSLTEQKIIRSCLEKEGINVLIASSGEEALEKVKSTRPDVIVLDVVLPGRSGFEICRQLKAEASTSTIPIIICSTKGSEMDKFWGMKQGADAYIPKPIDQAEFVQTVKQLIKQ
>NC_019689.1|WP_015144023.1|2612087_2613299_-|response-regulator
MTTANPSSQSPLIIRDFNAEKQAEFFEKLKQNRFSGQLVLTNPKGERWFFYFYLSRIIYATGGIHPVRRWRRNLITYFPQIASQPSIVQVDLANIAPDKLKICWEYELLCLWVEQQKITREQAAKMIRASIVEILFDITQGMAVACEIKPNILLPPRLVLIDGEQVIAESQQSWQAWQEAKIADRSPNSAPIVRQSEQLQQKTSPQVYQTLSQLLDGQQTLRDLSIRMKRHVLPVISSLLPYIQMGLVELVSVPDLASPVAPPPTPSGGTPIPITSGKAPLIACVDDSPLMCQTMEKILTAANYQFVGINDPLRAIAILLARKPDLIFLDLVMPNANGYEICGQLRRMTFFKDTPIVILTGNDGIVDRVRAKMVGSTDFISKPVDPEIVIGTIRKHLRQESPA
>NC_019689.1|WP_015144024.1|2613489_2613885_-|pre-16S-rRNA-processing-nuclease-YqgF
MILGFDPGRDKCGVAIVGLDRQLFYHQVVSAAVAIDTIKSLCQQFAIERLVIGNQTTAKQWRQQLKENLPSSVLIKMVDERNSSLEARDRYWQMYPPQGLQRLIPQGMRVPPRPVDDIVAILLIERYLQNV
>NC_019689.1|WP_015144025.1|2613964_2614282_-|DUF1825-family-protein
MGFFDSEVVQQEAKQLFEDYQSLMQLGSEYGKFDREGKKIFIEKMEQLMERYRIFMKRFELSEDFMAQMTVQQLKTQLSQFGVTPEQMFDQMHMTLERMKSEIKD
>NC_019689.1|WP_015144026.1|2614669_2615494_-|zinc-dependent-peptidase
MLNAIITFLIVAIVVTLIWLRPILREIRRDRLKNKSFPLHWRAIIEQNIPCYQTLPRSLQKQLHGHINVFLAEKQFLGCGGLQITDEIKLTIAAQACLLLLNQKGNYYPKLKSILVYPSAYIVKTTTPISDYLVEEKQEIRLGESWYRDRIVLSWEQIKYDTKNWQDGHNVIFHEFAHQLDGEDGSLNGVPLLDRQSDYITWARVFEREYKQLCSDVELGLKTVIDEYGATNPAEFFAVATETFFEKPKQMKRKHPGLYTELKHYYKLDPLEWI
>NC_019689.1|WP_015144027.1|2615829_2617233_+|3-isopropylmalate-dehydratase-large-subunit
MSKGTLFDKVWDAHAVKILPSGQTQLFIGLHLIHEVTSPQAFSMLRDRGLKVLYPERTVATVDHIVPTESQARPFLDDLAEEMMVAIEKNAKDYGIRFYNIGSGNQGIVHVIAPEQGLTQPGMTIACGDSHTSTHGAFGAIAFGIGTSQVRDVLASQTLALSKLKVRKIEVNGTLAPGVYAKDVILHIIRKLRVKGGVGYAYEYAGTTFEQMSMEERMTVCNMSIEGGARCGYINPDEVTFEYLKGRDFAPKGADWDKAVEWWKSIRSDDDAVYDDLVTFDASEIEPTVTWGITPGQGIGVSESIPTLEMLAESDRAIAQEAYSYMKLTPGQPIKGTKVNVCFIGSCTNGRISDLREAAKFAKGKHVAEGVKAFVVPGSERVKKQAEAEGLDKIFLEAGFEWREAGCSMCLAMNPDKLQGDQISASSSNRNFKGRQGSAMGRTLLMSPAMVVAAAVKGEVADVRELI
>NC_019689.1|WP_015144028.1|2617234_2618239_-|pentapeptide-repeat-containing-protein
MTSQSNATDHLTLGNQSETKTSLTATQLLERYAAGERKFRQVQLKRVDLKGASLAQIDLRGADLSYVNLREADLSSADLRDACLDGADLYKANLSRVNLQGARLGKANLKEANLTRASLEQAHLEGAFLTKALMSRANLKEVHLISAHLNEADLRYANLSNAYLDSAYLIQANIQKANLEEASLIGAFLSGASLGGANFHGGYYTDKTNFDTSFDPVGAGLRKVQKTTLEELLSAFKHLSESAIRYIGPKMTARYWESSRPEFEWLRQKFQVGSSGQISFSGNTAEPLTFVQLKYGYRWVDNFVESCSAIVQEFPNLIDRSKLEFYSSQDNREN
>NC_019689.1|WP_015144029.1|2618621_2620928_+|PhoD-like-phosphatase
MSEISFRDRLERLPLILAGPILHHTSSESVTVWVALKEPRWVAIEVYETAESGNVVGALVIAGERTTIALGRYLHIVAVTAKSHNGDSLRSGQLYAYDLSFTRTEGDRQTLKQALTSSSLPLVPISYFPHQLPTFALPPEDLERLQIVYGSCRKPHGKGYDALPILDSLLEHNAALPDFRPHQLFLTGDRIYGDDVADLLLYALTEVGDLLLGWQEQLPLLPSSKVSHLTPKQLKPGQRSKIACEQAGFTAGIRDKAEFAKSHLFGLGEYYAIYLFAWSQVFWLEPFPKGREIYQDRQAAKQWDRELKDLQQFASTIWKVRRALANVPRYTIFDDHDVSDDWYLNQAWCLRVLGKPLGRRVVQNALLAYAVFQGWGNTPEQFQDGQLGAKLLEAASEWSASAGGDKKAEEAIARYLGLPESNPLTGLPKMRLDGQFLILDRSPEALRWHYTVRGDGHEVIVLDTRTRRGYPADRDPIAPPALLCPSVFERQLRAVLQQVRSNIKATLAISPTNLFTLQAIDRIQQWHLKQGKVYHADVGDGWNMNASGLAAFLATLFEERDRVIILSGDIHYSATARLDYWSRRPSDSVVSESEQSFKPHLLTQFTSSALKNSELMTQLIHTKAKSILMPERRRFWIGWTNPPEMIEVRHTDRSLPEWKCSLEWIPRQPIQIPEWGKTVPWLRVQQKQNWLCNSVKWLWRNRWFQEGKEVVGTNNLGLIQFERSDNEGAAIQDIYWYTSWGNTRVGFSRFQASLHLRQLPNKIKSGGL
>NC_019689.1|WP_015144030.1|2621089_2621512_-|DoxX-family-protein
MQKFIPLIARTFLAVIFVRSGFDKAFFNFAATQQQMAEAGIPIPFVVLIFTIAFQIVGGISLILGYKAQIGAILLLIFLVPATLVFHNPIADPSQTIDFMKNLAILGGLLMVVSFGAGSLSLDARTRESKGYLRTTQLKE

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Crispr_ID: NC_019689_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_7

2921982-2922130

Orphan

Consensus_repeat	Method
AAAGGAGTCTAGGGATTCGGGTTCCAAGCTCTCAAAGCTAGCTGTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019689_7

>merge|NC_019689|7|2921982-2922130|CRISPRCasFinder
AAAGGAGTCTAGGGATTCGGGTTCCAAGCTCTCAAAGCTAGCTGTTTGTGGGGAAGCTTCGGCTGAGAACGTGTCTTGGGGGACTTCAGCTACTGGTTCAGTAAAGGAGTCTAGGGATTCGGGTTCCAAGCTCTCAAAGCTAGCTGTTT

>NC_019689|7|7|2921982-2922130|CRISPRCasFinder
AAAGGAGTCTAGGGATTCGGGTTCCAAGCTCTCAAAGCTAGCTGTTT	GTGGGGAAGCTTCGGCTGAGAACGTGTCTTGGGGGACTTCAGCTACTGGTTCAGT
AAAGGAGTCTAGGGATTCGGGTTCCAAGCTCTCAAAGCTAGCTGTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015144300.1\|2931991_2932963_-\|integron-integrase	unknown	unknown	gnl\|CDD\|131303
NC_019689.1\|WP_015144297.1\|2926938_2928879_+\|squalene--hopene-cyclase	unknown	unknown	gnl\|CDD\|273661
NC_019689.1\|WP_015144296.1\|2925223_2926804_-\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|227621
NC_019689.1\|WP_015144285.1\|2912189_2912720_-\|phycobiliprotein-lyase	unknown	unknown	gnl\|CDD\|319977
NC_019689.1\|WP_015144292.1\|2919028_2920480_-\|PP2C-family-protein-serine/threonine-phosphatase	unknown	unknown	gnl\|CDD\|225118
NC_019689.1\|WP_071880645.1\|2918760_2918964_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015144294.1\|2922925_2923864_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NC_019689.1\|WP_015144284.1\|2910545_2912168_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|270916
NC_019689.1\|WP_083888297.1\|2930445_2931159_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187616
NC_019689.1\|WP_071880610.1\|2929423_2929549_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|226674
NC_019689.1\|WP_083888341.1\|2913630_2914395_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223999
NC_019689.1\|WP_015144289.1\|2916770_2917226_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NC_019689.1\|WP_041392118.1\|2922423_2922720_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274528
NC_019689.1\|WP_015144295.1\|2923985_2925173_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|213815
NC_019689.1\|WP_015144290.1\|2917343_2918729_-\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NC_019689.1\|WP_015144299.1\|2931183_2931723_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NC_019689.1\|WP_015144286.1\|2912805_2913486_-\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|224331
NC_019689.1\|WP_015144293.1\|2920725_2921124_+\|4a-hydroxytetrahydrobiopterin-dehydratase	unknown	unknown	gnl\|CDD\|234845
NC_019689.1\|WP_144266202.1\|2914690_2916406_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015144298.1\|2928950_2929247_+\|DUF3288-family-protein	unknown	unknown	gnl\|CDD\|371670

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015144300.1\|2931991_2932963_-\|integron-integrase	gnl\|CDD\|131303	TIGR02249, Integrase/recombinase_E2_protein., integron integrase. Members of this family are integrases associated with integrons (and super-integrons), which are systems for incorporating and expressing cassettes of laterally transferred DNA. Incorporation occurs at an attI site. A super-integron, as in Vibrio sp., may include over 100 cassettes. This family belongs to the phage integrase family (pfam00589) that also includes recombinases XerC (TIGR02224) and XerD (TIGR02225), which are bacterial housekeeping proteins. Within this family of integron integrases, some are designated by class, e.g. IntI4, a class 4 integron integrase from Vibrio cholerae N16961. [DNA metabolism, DNA replication, recombination, and repair, Mobile and extrachromosomal element functions, Other].	1.07591e-166
NC_019689.1\|WP_015144297.1\|2926938_2928879_+\|squalene--hopene-cyclase	gnl\|CDD\|273661	TIGR01507, squalene-hopene_cyclase, squalene-hopene cyclase. SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other].	0
NC_019689.1\|WP_015144296.1\|2925223_2926804_-\|glycosyltransferase-family-39-protein	gnl\|CDD\|227621	COG5305, COG5305, Predicted membrane protein [Function unknown].	1.91016e-66
NC_019689.1\|WP_015144285.1\|2912189_2912720_-\|phycobiliprotein-lyase	gnl\|CDD\|319977	cd16339, CpcS, S-type phycobiliprotein (PBP) lyase. This family contains the S-type phycobiliprotein (PBP) lyase (denoted CpcS/CpcU or CpeS/CpeU). PBP lyases are employed by cyanobacteria, red algae, cryptophytes and glaucophytes for light-harvesting. Pigmentation of light-harvesting phycobiliproteins of cyanobacteria and cryptophytes requires covalent attachment of open-chain tetrapyrrole chromophores, the phycobilins, to the apoproteins. PBP lyases mediate this covalent attachment of phycobilin chromophores to apo-PBPs and also ensure the correct binding of the chromophore with regard to the specific attachment site and stereospecificity. The S-type lyase is distantly related to CpcT and similarly adopts a beta-barrel structure with a modified lipocalin fold. Many members of the CpcS/CpcU family ligate phycocyanobilin (PCB) to a specific cysteine residue in the beta-subunits of phycocyanin (CpcB) or phycoerythrocyanin (PecB) and to a related cysteine residue in the alpha and beta subunits of allophycocyanin (AP); they are typically given the designation of "CpcS" or "CpcU". Other members which attach phycoerythrobilin (PEB) to the beta-subunit of phycoerythrin (PE) are given the designation "CpeS" or "CpeU". In Guillardia theta, a Cryptophyte, which has adopted phycoerythrobilin (PEB) biosynthesis from cyanobacteria, phycobiliprotein lyase has been shown to provide structural requirements for the transfer of this chromophore to the specific cysteine residue of the apophycobiliprotein.	1.61728e-78
NC_019689.1\|WP_015144292.1\|2919028_2920480_-\|PP2C-family-protein-serine/threonine-phosphatase	gnl\|CDD\|225118	COG2208, RsbU, Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription].	4.81634e-87
NC_019689.1\|WP_015144284.1\|2910545_2912168_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.8967e-65
NC_019689.1\|WP_083888297.1\|2930445_2931159_+\|SDR-family-oxidoreductase	gnl\|CDD\|187616	cd05358, GlcDH_SDR_c, glucose 1 dehydrogenase (GlcDH), classical (c) SDRs. GlcDH, is a tetrameric member of the SDR family, it catalyzes the NAD(P)-dependent oxidation of beta-D-glucose to D-glucono-delta-lactone. GlcDH has a typical NAD-binding site glycine-rich pattern as well as the canonical active site tetrad (YXXXK motif plus upstream Ser and Asn). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.90875e-116
NC_019689.1\|WP_071880610.1\|2929423_2929549_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	1.56355e-09
NC_019689.1\|WP_083888341.1\|2913630_2914395_-\|alpha/beta-hydrolase	gnl\|CDD\|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	2.86835e-22
NC_019689.1\|WP_015144289.1\|2916770_2917226_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	2.35467e-30
NC_019689.1\|WP_041392118.1\|2922423_2922720_-\|hypothetical-protein	gnl\|CDD\|274528	TIGR03345, VI_ClpV1, type VI secretion ATPase, ClpV1 family. Members of this protein family are homologs of ClpB, an ATPase associated with chaperone-related functions. These ClpB homologs, designated ClpV1, are a key component of the bacterial pathogenicity-associated type VI secretion system. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0.00103647
NC_019689.1\|WP_015144295.1\|2923985_2925173_-\|glycosyltransferase	gnl\|CDD\|213815	TIGR03469, HpnB, hopene-associated glycosyltransferase HpnB. This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. Indeed, the members of this family appear to never be found in a genome lacking squalene-hopene cyclase (SHC), although not all genomes encoding SHC have this glycosyl transferase. In the organism Zymomonas mobilis the linkage of this gene to hopanoid biosynthesis has been noted and the gene named HpnB. Hopanoids are known to feature polar glycosyl head groups in many organisms.	0
NC_019689.1\|WP_015144290.1\|2917343_2918729_-\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NC_019689.1\|WP_015144299.1\|2931183_2931723_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	5.81999e-24
NC_019689.1\|WP_015144286.1\|2912805_2913486_-\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	1.8857e-33
NC_019689.1\|WP_015144293.1\|2920725_2921124_+\|4a-hydroxytetrahydrobiopterin-dehydratase	gnl\|CDD\|234845	PRK00823, phhB, pterin-4-alpha-carbinolamine dehydratase; Validated.	1.22103e-47
NC_019689.1\|WP_015144294.1\|2922925_2923864_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.56225e-31
NC_019689.1\|WP_015144298.1\|2928950_2929247_+\|DUF3288-family-protein	gnl\|CDD\|371670	pfam11691, DUF3288, Protein of unknown function (DUF3288). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	4.54883e-45

>NC_019689.1|WP_015144293.1|2920725_2921124_+|4a-hydroxytetrahydrobiopterin-dehydratase
MLSNLKKNLTLGIAIACLLLVHASYTLANEPPNNSTRLTQAEISQQIKNLPGWTLEDGQLRRTYSFSNFVEAIAFVNRLVAPAEAAGHHPDLSISYNRVTVSLTTHDAGGLTQKDFELAQIISQLFSQTQSE
>NC_019689.1|WP_015144292.1|2919028_2920480_-|PP2C-family-protein-serine/threonine-phosphatase
MTAVPIPRQPSSTDKNANPSGVRTETTPVLALKELVASLYREQNKIQNLLSSLGFALRSFNNLNQFLELTPLMAARVTDADGSALILLKSNGQISLEQLHCQEHQATQELRRLLDGVIRQANTSENQRNKNSNNSPILLLPSLLDEQIRQALGPQVRLYSTPVLVKNVERGRFYIFSSDPDYVWTQTRRKLLQLVADQTAVAIANNELTVELRSKERQDRELEIASEIQLRLLPRKCPKIQGVELAARCRNANRVGGDYYDFIPTNYDQLRQTQEGKIDKQTACCVPWSIVIGDVMGKGVPAGLIMTMTRGMLRAEVLNRHSPAQILQHLNRVMYADLDESHRFVTLFYSEYDPQSQILSYSNAAHNPPLMWRTSSQEIERLDTNGMLIGVDADSQYEDAKVQLKPGDTIIYYTDGFTDAVNPNGDRFEEKGLIEAFRQACQQCHSPQEILDYLFEQVDRFVSGENSNGDDMTLVVMRVQSSE
>NC_019689.1|WP_071880645.1|2918760_2918964_-|hypothetical-protein
MTFLPAKETSTASSAQYAVSIIAKIDKDVDVLAQMQDAFNNFIESGQVWALLIGFVLGYIFRSFTAY
>NC_019689.1|WP_015144290.1|2917343_2918729_-|argininosuccinate-lyase
MTEKKTWSDRFEGTLHPAIARFNASIGFDIELIEYDITGSIAHAKMLAHTGIIERSEAGQLVAGLEQIRQEYRNGKFNPGIEQEDVHFAVERRLIEIVGDVGKKLHTARSRNDQVGTDIRLYLRDRIDEIRHRLRQFQRVLLRHAEARVETLIPGYTHLQRAQPISLAHHLLAYFQMAQRDWERLGEIRSRTNILPLGCGALAGTTFPIDRQYSANLLGFEGVYGNSLDGVSDRDFAIEFLGAASLIMVHLSRLSEEIILWASQEFNFVTLKDSCATGSSIMPQKKNPDVPELVRGKSGRVFGHLQGMLVLMKGLPLAYNKDLQEDKEALFDAVKTVRACLEAITILLDEGLEFRDERLAEAVSEDFSNATDVADYLAARGVPFREAYNLVGKVVKTSLAAGKLLKDLTLEEWKQLHPAFEGDIYEAIAPKQVVAARNSYGGTGFEQVRQALATAKSLVEN
>NC_019689.1|WP_015144289.1|2916770_2917226_-|NUDIX-hydrolase
MLRAWRFISTVIGIIFRHPVTGTTIIPILPDGRIILIRRRDTGQWSLPGGIVDWGEDIATTARRELAEETGLELVKIRRLVGVYSSPDRDPRIHSITVSIEAEVRGALAIGDTLEVSDAKAFLPEDLPLGNLSHDHDRQLQDYFKGSTILA
>NC_019689.1|WP_144266202.1|2914690_2916406_-|hypothetical-protein
MKSSKLFSHPNTSFWFSLSLSVNLYFGLVSIGHGFSQDYIVQDDVRQHVVWLQRFVDPQLFPNDLIADYFQTLAPVGYKFFYWSMAKLGIESILLAKILPLVLGFIATVYLFFFSLKIFPIPSGAFLISLLFNQVIWNNDDLISATPRSFVYPLFAAFLYYLVQRSLIPILISVALQGLFYPQLLLVEVAILTVRLFRWQRGLPQLSQDRQDYFFWLSGLGVAFVVLLPFILDRSEFSTVVTLAQMKAMPEFGFRGRNQYFGVNPIWFIFMGSSGIKLPLFPSIVWFAFALPFWHKSQLSLAKFVTEDAKILWQIVIASLGMFFLAHLLLPKLHLPSRYTHHSIRFVMPIAAGIVLLVLLESGWRWLSKKRLTKAKFTRKESFLLGLVALFATIVIIVPAIPSGVLFLFQTWIVGDAPAVYEFLSKQPKNILVASIAQEADNIPAFSQRSLLASREFALAYHPAYYNRIQQRTIDTIRAQYSSDLSVTKSIIQKYSIDFLLIERNSFQPDYLLKQEWLTRSSFRDSVFATINRLEKGEIPALEKLSDRCSVVSTEKFILLEAACITKVEEN
>NC_019689.1|WP_083888341.1|2913630_2914395_-|alpha/beta-hydrolase
MIFFPPAGIATTPAEVNLSYEEVWLPVSTGKIHGWWIRSPKAEAPVLLYFHGNGSNIGDNVHRASRFHQLGLSVLLIDYRGYGKSSGPFPNESLVYEDAEAAWTYLTQQRRIAPKNIFLYGHSLGGAIAIEMAARHPDIAGIIVEGAFTSVRAVVDEVSLYRLFPVDLILTQRFDSLAKVRSLQMPILFIHGTADEIIPVKMSQELYQAAPEPKQLLLVPNAGHNDTAELGGMQYLQTIWEFIEQTRKRNASLR
>NC_019689.1|WP_015144286.1|2912805_2913486_-|HEAT-repeat-domain-containing-protein
MNQPSLEQIAVQLESPNSRDRLLALVSLRQFPAADAVPLIKKVLYDEILPVRSMAVFALGVKQTEECYEILVKLLETDPDYGIRADAAGALGYLEDGRAFEPLVRAFYEDTEWLVRFSAAVSLGNLKDIRAKEVLLKALESEEAVLHQAAIAALGEIEAVDTVDRLLQFAPSEDWLIRQRLAEALGNLKTEKSISALKFLAKDPHPQVSQAATLSLERLEEGSTEQ
>NC_019689.1|WP_015144285.1|2912189_2912720_-|phycobiliprotein-lyase
MEIEEFLELCAGKWFSQRTSYHLDETKVENHKADLTVERLSRDRPEIITLCQQHKIDPSHTLGGTKTWWDNSVDWGKPKQSGSSVTILVPDRDNSQTGQLLFAAGMPLTTISLGSFVLGNDQALTLIIEKDKTYLEERLWFASPNLRLRTSLVKNAHGFSRTAFYSEIRKIPPKST
>NC_019689.1|WP_015144284.1|2910545_2912168_+|pentapeptide-repeat-containing-protein
MSYCVNPSCSQPKNPKNAEVCQACGSSLILRGRYRVLGILGKGGFGATFVAVDLSLPGKPWCVVKQLRPSTDDPALFKMAKELFEREAETLGRIGNHPQVPRLLDYFEDRQQFYLVQEYVKGHNLHQEVKKNGPFSEAGVRQFLSEVLPILQYIHTQRVIHRDIKPANIIRREEDRQLVLIDFGAVTNQVNSVANSASTQTAFTAFAVGTAGFAPPEQMAMRPVFASDIYAVGVTCLYLLIGKSPKDLGTDPTTGEITWERWITVSESFAKVLKTMLEVSVRHRYKTANEVLQALELVPYSESLAQSMINAPNLEKGTGNSAILATTPISKIGMGDRTRIDRATRTSANPPTPNLPSKAAAGSNFSAALNYQMSSNYAIDKNRLASPSKSPASKKPVPKLDANSIVEGYKNGRRDFAQQELNNLNLSRASLPGAIFHQSQLNQANFQRANLANADFGHANLTHADLRNANLSRAYLSYADLKGADLRGADLSFAHLTYANLKGANLCGANLTNAKVTEEQLVYAKTNRSTIMPTGRKGFW
>NC_019689.1|WP_041392118.1|2922423_2922720_-|hypothetical-protein
MEFVFVGIIGFLLGAGLLYWLQKRQLENTQHRLEQARVALEQTEAQLRELQQSQGKSPEEIEKSYQNRIQALEQAHQSKLEEIEAAYQARIEELRANL
>NC_019689.1|WP_015144294.1|2922925_2923864_-|glycosyltransferase-family-2-protein
MFFSVVIPTYNRKLILEKCLVALENQQLTDTKVSSYEVVLVDDGSTDGTLGWLADRADKFPRVRCFSQVRQGAAAARNLGVEQAKGDIIIFIDSDLIVTEQFLQAHADALVKGEKQLGSDRLFTYGWVINTCNFDNPTAEPYKLTDFSAAYFATGNVAIARKWLEQAGLFDTRFQLYGWEDLELGVRLKKLGLKLIKCPAAVGYHWHPPFSLDQIPKLIEKEIHRGRMGVLFYQKHPTWEVRMMIQMTWLHRLLWGLLSCGGRFNEHSMAPLLQWLIDRGKSQLALEIARIFLNWHNVRGVYAAYEEIQQSS
>NC_019689.1|WP_015144295.1|2923985_2925173_-|glycosyltransferase
MSDRIFLSLIIISAIIWIYLLGFRGQFWRSNQRFKPQTIELESYPSVTAIIPARNEAELLPIALRSVLNQDYPGSFSVILVDDRSTDGTANLAKEVAEKSSKPQQLKVIESQPLPPGWTGKLWAIEQGISQAQKITPLPDYFWLTDADIEHDLTNLRQLVIKAQRDNLNLVSLMVLLKCQTFWEKLLIPAFVFFFQKLYPFAWVNDPNNPTAAAAGGCIVIQRQALECIGGIQAVRQALIDDCTLAQAVKSSSQSDRTKSIWLGLTTTTHSLRTYSSLSRIWDTIARTAFTQLNYSAWLLLATLLGMVLTYLVSPIGLVISILTRDWITAITSLFTWSLMTVAYLPTIRLYKISSLWAFYLPAIAFLYILMTIDSAVRYWRGQGGAWKGRVYPQV
>NC_019689.1|WP_015144296.1|2925223_2926804_-|glycosyltransferase-family-39-protein
MQTTSVKRSGLEKPGRIWVSNWRWLYALLAIVLAIGIFFRFANLDRKVYWNDEAVTSLRISGYTEAEIIQQVYDGRAIDVSEIMKYQRPNPEKGLDGVINSLATEDAHLSLLYHVLARVWVDWFGSSIAAIRSLSALLSLLALLCLYWLCRELFNSPLTGWIGMALMAVSPFHVLYAQEARQYSLWTVTLLLSSAALLRALRVQTKISWVVYAATAALAIYSHTLSILVVAGQGIYVLCIERFRLSKRFFAYLLSAIGGFLAFVPWLIVAIAQSSKISSNVSRTNINIGLLALIKSWCQSLYRIFVDIPNLGDYFFPIIFLLTIYALYYLVRKRSKETYLFIVILIGTALALAIPDILLGGKRSSDSRYLIPSYLGIELAIAYLFSTQLVALKSRWKSFWSFVLVALMSVGIVSCAISSQAQAWWNKSSGYYNPQIAEIINQTNNSLVISDNTPGRILSLSHLLNRRVKLLLLSRPDSLKISGNFDNIFVYQPSSKLEKQIEQEKNYHLKDMLKGWLWKLDKIGDR
>NC_019689.1|WP_015144297.1|2926938_2928879_+|squalene--hopene-cyclase
MQTQDRVTRNGDSKAFSKVSEAIAASQNYLLSIQDPQGYWWAELESNVTITSEVVLLHKIWGTDRDRPLHKVEAYLRAEQREHGGWELFCGDGGDLSTSVEAYMALRLLGVPQSDPALLRAKDFILKRGGISKTRIFTKIHLALIGCYDWRGVPAIPPWIMLFPENFPFTIYEMSSWARSSTVPLLIVFDRKPVFVTEPAITLDELYAEGIENARYELPLRGDWTDVFVWLDKAFKLAEDLHLVPWRQAGVDAAEKWILERQEVSGDWGGIIPAMLNSLLSLRVLGYDTADPVVERGLKAIDNFAIATEETYRVQPCVSPVWDTAWTLRALVESGIAPDNPALARGGEWLLGKQILSYGDWAVKNKQGKPGGWAFEFENRFYPDLDDSAVVVMALNGLKLPNESLKQAAIKRCVAWMATMQCRSGGWAAFDVDNDQNWLNYLPYADLKAMIDPNTADVTARVLEMLGSGNLMMDSDRVERATAFLEKQQEADGSWFGRWGVNYIYGTSGAISALAVIAPRTHQRQLQGGAAWLVGCQNPDGGWGETCRSYDDPTLKGKGVSTASQTAWALIGLLAAGQATGKFEQRAIESGINYLVAVQRSDGTWDECEFTGTGFPGHFYLKYHLYQQYFPLIALSRYQRLQPYIS
>NC_019689.1|WP_015144298.1|2928950_2929247_+|DUF3288-family-protein
MASAANSQDQRHPLEKQDREIVNRLLQGNPDPLNLAELARLRIRYRNFPGARDIQRDLDVILRQWQITEEQLFEKTRQLHLTERIYQRRQSEEQQDWS
>NC_019689.1|WP_071880610.1|2929423_2929549_+|SDR-family-NAD(P)-dependent-oxidoreductase
MKGLKDKNALITGATSGIGQAIAIRLAQEGCNRPPAKVRVS
>NC_019689.1|WP_083888297.1|2930445_2931159_+|SDR-family-oxidoreductase
MAINYRKSPEAAEDTEEIALQKACGNIENCGVQSLLVQGDVSSEQDIVEMVNTVVEKFGSLDLLINNAGIQIECPSHEVKTQAFDRVLGVNLRGAYLCACEAIKHFLTQNHPGTIINISSVHEIIPRPMYVSYSISKGGMENMTKTLALEYANRGIRVNAIAPGATITPINEDWTKDPEKKAVVESHIPMGRAGTPEEMAAAVAFLASSDATYITGQTLFIDGGLTLYANFREAWSA
>NC_019689.1|WP_015144299.1|2931183_2931723_+|pentapeptide-repeat-containing-protein
MNRSNFLKILSHWSVNAVFLTLTVGSMAIAMPKAIAQSTAPEASTELRRLLDTKECAGCNLSGVDLQNANLQGANLEGANLQNADLEEANLQGANLAGANLQGADLEKGNLAGANLQTANLINADLEEANLQNANLQGASLQRADLEKANLTGANTNEANLQGANLENAIGIDPTAQTR
>NC_019689.1|WP_015144300.1|2931991_2932963_-|integron-integrase
MTEPQPPRLLDRVRDTLRLKHMSLKTEKSYVYYIKEFILFHNKRHPREMGVEEIRAYLSHLAINKNVAASTQNVARNALLFLYKEVLQIALPFIDGIQPAKRPQRLPVVFTREEVQAILANLKGVHHLMASLLYGSGLRLTECLNLRVKDIDFGYQQIVIRDGKGHKDRITTLPKLTIEGLKLQLENARYLHQQDLAQGYGAVYLPYALEQKYPHANREWAWQFVFPANNRSKDPRSGIVRRHHIYPDSLQRAVKTAIRQAGITKHASCHTFRHSFATHLLEDGYDIRTVQELLGHKDVRTTMIYTHVLNRGGRGVRSPLDFQ

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Crispr_ID: NC_019689_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_8

2940444-2940585

Orphan

Consensus_repeat	Method
ATAGCCAGAAAAATTCTTGATAT	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_019689_8

>merge|NC_019689|8|2940444-2940585|CRISPRCasFinder
ATATGCGGAATAGTTCTGGATATCATCCTTTTTCGGATAATAGCCAGAAAAATTCTTGATATCTACCCCAAATCAGGTAGTTATCCAGAAATTTTCTGTATAATAGTTGGATATTGACGATATCCAGAAAAATTCTTGATAT

>NC_019689|8|8|2940444-2940585|CRISPRCasFinder
ATATGCGGAATAGTTCTGGATAT	CATCCTTTTTCGGATA
ATAGCCAGAAAAATTCTTGATAT	CTACCCCAAATCAGGTAG
TTATCCAGAAATTTTCTGTATAA	TAGTTGGATATTGACG
ATATCCAGAAAAATTCTTGATAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015144300.1\|2931991_2932963_-\|integron-integrase	unknown	unknown	gnl\|CDD\|131303
NC_019689.1\|WP_015144304.1\|2938570_2938996_+\|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl\|CDD\|223317
NC_019689.1\|WP_015144301.1\|2933247_2934141_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377686
NC_019689.1\|WP_015144309.1\|2944465_2945626_-\|alpha-D-ribose-1-methylphosphonate-5-triphosphate-diphosphatase	unknown	unknown	gnl\|CDD\|237967
NC_019689.1\|WP_015144308.1\|2943890_2944460_-\|phosphonate-metabolism-protein/1,5-bisphosphokinase-(PRPP-forming)-PhnN	unknown	unknown	gnl\|CDD\|274078
NC_019689.1\|WP_015144311.1\|2946464_2947313_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|183280
NC_019689.1\|WP_015144305.1\|2938995_2939379_+\|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl\|CDD\|376809
NC_019689.1\|WP_083888297.1\|2930445_2931159_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187616
NC_019689.1\|WP_015144313.1\|2948336_2949443_-\|carbon-phosphorus-lyase-complex-subunit-PhnI	unknown	unknown	gnl\|CDD\|377563
NC_019689.1\|WP_015144303.1\|2935700_2937074_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366721
NC_019689.1\|WP_144266124.1\|2941963_2942176_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183052
NC_019689.1\|WP_051036435.1\|2943330_2943900_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293822
NC_019689.1\|WP_015144307.1\|2941061_2941871_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_019689.1\|WP_144266088.1\|2942244_2943311_-\|ISKra4-like-element-ISPle1-family-transposase	unknown	unknown	gnl\|CDD\|284250
NC_019689.1\|WP_083888298.1\|2939397_2939571_+\|DUF190-domain-containing-protein	unknown	unknown	gnl\|CDD\|376875
NC_019689.1\|WP_015144312.1\|2947296_2948214_-\|alpha-D-ribose-1-methylphosphonate-5-phosphate-C-P-lyase-PhnJ	unknown	unknown	gnl\|CDD\|377586
NC_019689.1\|WP_015144310.1\|2945678_2946416_-\|phosphonate-C-P-lyase-system-protein-PhnL	unknown	unknown	gnl\|CDD\|131377
NC_019689.1\|WP_015144299.1\|2931183_2931723_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NC_019689.1\|WP_015144302.1\|2934175_2934661_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_071880610.1\|2929423_2929549_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|226674

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015144300.1\|2931991_2932963_-\|integron-integrase	gnl\|CDD\|131303	TIGR02249, Integrase/recombinase_E2_protein., integron integrase. Members of this family are integrases associated with integrons (and super-integrons), which are systems for incorporating and expressing cassettes of laterally transferred DNA. Incorporation occurs at an attI site. A super-integron, as in Vibrio sp., may include over 100 cassettes. This family belongs to the phage integrase family (pfam00589) that also includes recombinases XerC (TIGR02224) and XerD (TIGR02225), which are bacterial housekeeping proteins. Within this family of integron integrases, some are designated by class, e.g. IntI4, a class 4 integron integrase from Vibrio cholerae N16961. [DNA metabolism, DNA replication, recombination, and repair, Mobile and extrachromosomal element functions, Other].	1.07591e-166
NC_019689.1\|WP_015144304.1\|2938570_2938996_+\|fluoride-efflux-transporter-CrcB	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	4.52016e-30
NC_019689.1\|WP_015144307.1\|2941061_2941871_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.35973e-56
NC_019689.1\|WP_015144309.1\|2944465_2945626_-\|alpha-D-ribose-1-methylphosphonate-5-triphosphate-diphosphatase	gnl\|CDD\|237967	PRK15446, PRK15446, phosphonate metabolism protein PhnM; Provisional.	5.60751e-173
NC_019689.1\|WP_015144308.1\|2943890_2944460_-\|phosphonate-metabolism-protein/1,5-bisphosphokinase-(PRPP-forming)-PhnN	gnl\|CDD\|274078	TIGR02322, Ribose_15-bisphosphate_phosphokinase_PhnN, phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN. Members of this family resemble PhnN of phosphonate utilization operons, where different such operons confer the ability to use somewhat different profiles of C-P bond-containing compounds (see ), including phosphites as well as phosphonates. PhnN in E. coli shows considerable homology to guanylate kinases (EC 2.7.4.8), and has actually been shown to act as a ribose 1,5-bisphosphokinase (PRPP forming). This suggests an analogous kinase reaction for phosphonate metabolism, converting 5-phosphoalpha-1-(methylphosphono)ribose to methylphosphono-PRPP. [Central intermediary metabolism, Phosphorus compounds].	1.32126e-75
NC_019689.1\|WP_015144311.1\|2946464_2947313_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|183280	PRK11701, phnK, phosphonate C-P lyase system protein PhnK; Provisional.	5.09635e-108
NC_019689.1\|WP_015144305.1\|2938995_2939379_+\|fluoride-efflux-transporter-CrcB	gnl\|CDD\|376809	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB). CRCB is a family of bacterial integral membrane proteins with four TMs.. Over expression in E. coli also leads to camphor resistance.	4.80369e-26
NC_019689.1\|WP_083888297.1\|2930445_2931159_+\|SDR-family-oxidoreductase	gnl\|CDD\|187616	cd05358, GlcDH_SDR_c, glucose 1 dehydrogenase (GlcDH), classical (c) SDRs. GlcDH, is a tetrameric member of the SDR family, it catalyzes the NAD(P)-dependent oxidation of beta-D-glucose to D-glucono-delta-lactone. GlcDH has a typical NAD-binding site glycine-rich pattern as well as the canonical active site tetrad (YXXXK motif plus upstream Ser and Asn). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.90875e-116
NC_019689.1\|WP_015144313.1\|2948336_2949443_-\|carbon-phosphorus-lyase-complex-subunit-PhnI	gnl\|CDD\|377563	pfam05861, PhnI, Bacterial phosphonate metabolism protein (PhnI). This family consists of several Proteobacterial phosphonate metabolism protein (PhnI) sequences. Bacteria that use phosphonates as a phosphorus source must be able to break the stable carbon-phosphorus bond. In Escherichia coli phosphonates are broken down by a C-P lyase that has a broad substrate specificity. The genes for phosphonate uptake and degradation in E. coli are organized in an operon of 14 genes, named phnC to phnP. Three gene products (PhnC, PhnD and PhnE) comprise a binding protein-dependent phosphonate transporter, which also transports phosphate, phosphite, and certain phosphate esters such as phosphoserine; two gene products (PhnF and PhnO) may have a role in gene regulation; and nine gene products (PhnG, PhnH, PhnI, PhnJ, PhnK, PhnL, PhnM, PhnN, and PhnP) probably comprise a membrane-associated C-P lyase enzyme complex.	0
NC_019689.1\|WP_015144303.1\|2935700_2937074_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	4.1659e-65
NC_019689.1\|WP_144266124.1\|2941963_2942176_-\|hypothetical-protein	gnl\|CDD\|183052	PRK11244, phnP, carbon-phosphorus lyase complex accessory protein; Provisional.	6.02955e-24
NC_019689.1\|WP_051036435.1\|2943330_2943900_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293822	cd07736, PhnP-like_MBL-fold, phosphodiesterase Escherichia coli PhnP and related proteins; MBL-fold metallo hydrolase domain. Escherichia coli PhnP catalyzes the hydrolysis of 5-phospho-D-ribose-1,2-cyclic phosphate to D-ribose-1,5-bisphosphate, a step in the C-P lyase pathway. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.75247e-99
NC_019689.1\|WP_015144301.1\|2933247_2934141_+\|hypothetical-protein	gnl\|CDD\|377686	pfam06677, Auto_anti-p27, Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27). This family consists of several Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) sequences. It is thought that the potential association of anti-p27 with anti-centromere antibodies suggests that autoantigen p27 might play a role in mitosis.	0.00309706
NC_019689.1\|WP_144266088.1\|2942244_2943311_-\|ISKra4-like-element-ISPle1-family-transposase	gnl\|CDD\|284250	pfam06782, UPF0236, Uncharacterized protein family (UPF0236).	1.70142e-05
NC_019689.1\|WP_083888298.1\|2939397_2939571_+\|DUF190-domain-containing-protein	gnl\|CDD\|376875	pfam02641, DUF190, Uncharacterized ACR, COG1993.	1.99765e-11
NC_019689.1\|WP_015144312.1\|2947296_2948214_-\|alpha-D-ribose-1-methylphosphonate-5-phosphate-C-P-lyase-PhnJ	gnl\|CDD\|377586	pfam06007, PhnJ, Phosphonate metabolism protein PhnJ. This family consists of several bacterial phosphonate metabolism (PhnJ) sequences. The exact role that PhnJ plays in phosphonate utilisation is unknown.	0
NC_019689.1\|WP_015144310.1\|2945678_2946416_-\|phosphonate-C-P-lyase-system-protein-PhnL	gnl\|CDD\|131377	TIGR02324, phosphonate_uptake_transporter_ATP-binding_protein, phosphonate C-P lyase system protein PhnL. Members of this family are the PhnL protein of C-P lyase systems for utilization of phosphonates. These systems resemble phosphonatase-based systems in having a three component ABC transporter, where TIGR01097 is the permease, TIGR01098 is the phosphonates binding protein, and TIGR02315 is the ATP-binding cassette (ABC) protein. They differ, however, in having, typically, ten or more additional genes, many of which are believed to form a membrane-associated C-P lysase complex. This protein (PhnL) and the adjacent-encoded PhnK (TIGR02323) resemble transporter ATP-binding proteins but are suggested, based on mutatgenesis studies, to be part of this C-P lyase complex rather than part of a transporter per se.	1.25615e-96
NC_019689.1\|WP_015144299.1\|2931183_2931723_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	5.81999e-24
NC_019689.1\|WP_071880610.1\|2929423_2929549_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	1.56355e-09

>NC_019689.1|WP_083888298.1|2939397_2939571_+|DUF190-domain-containing-protein
MSNAEQLTIYVTEGDRAQGKLLYRVLMNAARQSNIAGMTVAPAAVGYGQRYRHKLLI
>NC_019689.1|WP_015144305.1|2938995_2939379_+|fluoride-efflux-transporter-CrcB
MEASDFLPVWIVLGAIPGALSRYYLTLICTQRLDGNFPYGTFLINLTGAFLMGFSATVLQKMSAEQWLSGFTTIGFLGAYTTFSTYALDFSNLLKLGNYKQALLYGLGSPTGGFLAVEMGIALAQHL
>NC_019689.1|WP_015144304.1|2938570_2938996_+|fluoride-efflux-transporter-CrcB
MLKQPVVRTVMAISLGAIAGALCRYYLGLGIGHLLGTALPYGTLFVNITGCFVMGLLATLSLGQVISLHPDLRLLLLTGFLGSYTTFSSYELDSAKLLFQKDLRADLIYWAGSVLLGIISLQLGITLAEWMLKKLDRNWSS
>NC_019689.1|WP_015144303.1|2935700_2937074_-|FAD-dependent-oxidoreductase
MSSIADVLVVGAGLSGLYAARSLQRAGLTVTVLEARDRVGGRVLSQTLVNGVTIDLGGQWIGPGQQRMYALAKEYGLNTIVTHTQGESVFLVDGHYQRTSDTIPPMSWFAKLDISQLGWRIDRLLNQLTIAEPWQHPRAGYLDSISVNQWLQKNSFSKAARSYWLHLFESGFCASADRVSPLEVLHQIATIGGLEKLETAEYEFFADGAQTVARRMAEELGDCVYLQTPVRSLKRQGKFVQAITDQGKFTGEHVILALPPQLINQITFEDGLTHPFPHQPGERVLGQVVKIPIVYDCAWWREAGLSGIAIAPDELINFLADGSSPSGKPGILIALATGSRAVQLSLMDSETRKATALACIQKMLGNASGHLTNFIAMDWIAEPFSRGGYASRWGIGGWSHRQNSSVSPDRCIHVAGSETATEWRSYMEGALQSAERASTEVLNAMKGKTLDLQQKSE
>NC_019689.1|WP_015144302.1|2934175_2934661_+|hypothetical-protein
MNVRKSQVPLKQIVGNINKYESYREAWSRIKLAQENHFFLEAITIQESIISDRLISFLSRPEALNPPSKRKNGQFPSLNQLIKQWRSEFPHALQSGSYSDLISAVDQWRRTRNEAIHAIVKSEPGEPTQPIDSFLQKAKEAAEEGEKLTREVCKWCKRGKK
>NC_019689.1|WP_015144301.1|2933247_2934141_+|hypothetical-protein
MEEQLSLEACPKCGSPLRPPLKTTGRQICVKCGWTNIKRESKSSVKSDVSSTSKIESLISSWKQKISFVNELLKLNKNVKYGLASVIGIAVIGWGSTSLYFKHQADSCRTETKEAIGKISEEWDDVMSRAKASNRLNMQANISDLQHIKRKVSDAKWPQCALVAKSAVWVGMQSDINQLLKFAGGDDISYDKSFAWKIFADEIKQITSSGETNHSVNSEDDAKKAVEALFIEEINKINAQMEPLKQPFSEYESKSNQLSMSLYDQQRNLREQYKDVVSKYTDLQLEKTKLEMDKLLL
>NC_019689.1|WP_015144300.1|2931991_2932963_-|integron-integrase
MTEPQPPRLLDRVRDTLRLKHMSLKTEKSYVYYIKEFILFHNKRHPREMGVEEIRAYLSHLAINKNVAASTQNVARNALLFLYKEVLQIALPFIDGIQPAKRPQRLPVVFTREEVQAILANLKGVHHLMASLLYGSGLRLTECLNLRVKDIDFGYQQIVIRDGKGHKDRITTLPKLTIEGLKLQLENARYLHQQDLAQGYGAVYLPYALEQKYPHANREWAWQFVFPANNRSKDPRSGIVRRHHIYPDSLQRAVKTAIRQAGITKHASCHTFRHSFATHLLEDGYDIRTVQELLGHKDVRTTMIYTHVLNRGGRGVRSPLDFQ
>NC_019689.1|WP_015144299.1|2931183_2931723_+|pentapeptide-repeat-containing-protein
MNRSNFLKILSHWSVNAVFLTLTVGSMAIAMPKAIAQSTAPEASTELRRLLDTKECAGCNLSGVDLQNANLQGANLEGANLQNADLEEANLQGANLAGANLQGADLEKGNLAGANLQTANLINADLEEANLQNANLQGASLQRADLEKANLTGANTNEANLQGANLENAIGIDPTAQTR
>NC_019689.1|WP_083888297.1|2930445_2931159_+|SDR-family-oxidoreductase
MAINYRKSPEAAEDTEEIALQKACGNIENCGVQSLLVQGDVSSEQDIVEMVNTVVEKFGSLDLLINNAGIQIECPSHEVKTQAFDRVLGVNLRGAYLCACEAIKHFLTQNHPGTIINISSVHEIIPRPMYVSYSISKGGMENMTKTLALEYANRGIRVNAIAPGATITPINEDWTKDPEKKAVVESHIPMGRAGTPEEMAAAVAFLASSDATYITGQTLFIDGGLTLYANFREAWSA
>NC_019689.1|WP_071880610.1|2929423_2929549_+|SDR-family-NAD(P)-dependent-oxidoreductase
MKGLKDKNALITGATSGIGQAIAIRLAQEGCNRPPAKVRVS
>NC_019689.1|WP_015144307.1|2941061_2941871_-|GntR-family-transcriptional-regulator
MTLSTSDALPRYKQIAYHIIDAIQTGHYLPGEKLPSENQLAAKYQVHRLTVRHAMNLLAQQGFIYRHQGKGSFVAEPNLYYAIGAKTSFSHAMLELGYLPCFKILSVKTRSATAELMEVLQIAAQVAILEIKILRTATAAMVGPKVPAFQPLCISCSYLREDQFPQLSQKIYHAQSLYGLLKQHYGVVPQRRWTRIAAEAATPEDVALLDMPPQIPVLITQGLAQTDQGDLIDYTVTRFRSDRFILEIPLHPVKPASPELSETFAYSLL
>NC_019689.1|WP_144266124.1|2941963_2942176_-|hypothetical-protein
MIDCDHPPQPTQPRNHNDVPRALAILDALQPRQGYLTHMGHECDRWLMVQADFLPATVRCAQDGDIIALQ
>NC_019689.1|WP_144266088.1|2942244_2943311_-|ISKra4-like-element-ISPle1-family-transposase
MNQEKQERIKACLQELSTLLYEEADKSKLTDLEGIEKTVRSQVLELVSPEIAPFFIEQKTGTKVGKTRKIKSLVGELKLKAKQLIRLGLKPRTRLSPLLQKCCLRLSANESYQKAEIEIEALTGVKVGHSTQQQLVLSQDFQLPLAKQSVSEVSVDGGKVRLRGKPKAGCHWRDYKTVRLQGIYYGAFFDDNQSLIDYVNSQQLLDPLVCLGDGHDGVWNLVREFGQDQFSRCEILDWYHLKENLYKVGGSLKRLKAAETLLWQGQVEAAKTLFNHCRGKQAKNFIAYLEKHLPRIVNYSYYQAEQLCSIGSGAVESAIKQIGLRIKISGAQWNVESVNHILSVRCAYLNGLLAV
>NC_019689.1|WP_051036435.1|2943330_2943900_-|MBL-fold-metallo-hydrolase
MRLTLLGTGDAGGVPCYGCNCVVCNRARQNPTYRRRPCSALLNWGSESWLIDGGLMDLGDRFSPGTLSGILLTHFHVDHVQGLFHLRWGMGAPITVHCPPDPQGCADLYRNPGLLRFQPLTAFTPISLGQGQVIPIPLQHSKLTFGYCMEDSSGKLAYLTDTVGLPPKTQRWEHPVLEDLPFMGKCKGK
>NC_019689.1|WP_015144308.1|2943890_2944460_-|phosphonate-metabolism-protein/1,5-bisphosphokinase-(PRPP-forming)-PhnN
MTTQGQLFYVIGASGSGKDSLMRYARTHLNGHQRVLFAHRYITRPFEVGGENHVALTTAEFAERLHHGCFAMHWQSHGYHYGVGIEINQWLSWGFRVVVNGSRAYLPQAQAHYPKIRPVLVKTSPAILAQRLQARQRETPEEIAARLRRSEQIHWPQAGLVEIDNDQPLEKAGQDFLDLLTEGVWPLCG
>NC_019689.1|WP_015144309.1|2944465_2945626_-|alpha-D-ribose-1-methylphosphonate-5-triphosphate-diphosphatase
MTNTYLTNATLITADHVLPDSTLLLEDGHIAAINPEVIPAAANTIDLGGHYLLPGLVDLHCDAIEKEIEPRPNAFFPLEFAIAQIDQRNAALGITTPFHAISFAHEELGVRNNDKAAEIVRLLHACQTHTLVNNRVHCRYEITDPTGLPILLDLMGEQDIHLISLMDHTPGQGQFKDLQAFQAYFARTYHKSTAEVEEIAARKLDQAADALDRVKTLIEAAHQQCITVASHDDDTPERVDSMAALGVHISEFPINPATAQAATARSLSTVFGAPNLLRGQSQSGSMKAIDAVRQRLCDVLCSDYSPASLLAAAFKIPELVTDWTLPEAIALITRNPARATQLTDRGEIAPGQRADLIVVRHDLGFPQVVSTWVAGQEVYRNRYATR
>NC_019689.1|WP_015144310.1|2945678_2946416_-|phosphonate-C-P-lyase-system-protein-PhnL
MTLTATTPLRHSTTALTNPVLLRVTGLTKDFVLHEQRKTLPGAKPISFTAQQGQLTALSGPSGAGKSSLLKCVFRTYLPTAGRIDYLTATGAWVNLAQASDAEILALRRQEIGFVTQFLHFLPRQPTLDVVAKPLFELGLDRQEARDRAAALLEHMHLPKRLWHLSPATFSGGEKQRVNLARSMALQPRLLLLDEPTASLDHAAAERVVELIHDIKARGTALLAVFHDPEIIQTLADTVVTVEPA
>NC_019689.1|WP_015144311.1|2946464_2947313_-|ATP-binding-cassette-domain-containing-protein
MQPLLDVCNLTKIYGAGCPHCLSATGATAQTNICPHCGSLVAMQEVSFSLYPGEILGIMGESGSGKSTLVKTLYLDQLPTAGTAVFRDGDEATETVQSYDLFSLNGAQQRWLQHHKFGMVYQNPHLGLNFRVSAGGNIAERLLMADLLDYSTIRDRARTLLERTEILPERMDELPSDFSGGMQQRVQIARALATNPPLLFLDEVTTGLDLSVQAKILDLILEIQQQLGVAMIVVTHDLGVIRLLTTRTLVMKYGQVVEAGLTDQVLEDPQHAYTQQLVASAL
>NC_019689.1|WP_015144312.1|2947296_2948214_-|alpha-D-ribose-1-methylphosphonate-5-phosphate-C-P-lyase-PhnJ
MLTPTVTPPQSFGFLDNYAKKEIRRTLLKAVSIPGYQVPYSSREMPIARGFGTGGLQITLSLLKPTDTLKVIDQGSDESVNAVNLRKFVAATSPGVTMTSHTPEATLIQTRHRIPEFPLKLGQILVLQVPYPDALVLVEASEAKRKRMHGEGDYARLWVKLYEDMVKFSEITISHRYPTRINGHYVIDPSPIPRFDVPKLHQSPGLYLFGAGREKKIYAVPPYTDAEPLSFDDIPFQVEDFTDERGHRRACAICGSTTSFLDECLNDAGDRIYQCSDSDYCLTTLREAHPPVPQPTPETAHATLA
>NC_019689.1|WP_015144313.1|2948336_2949443_-|carbon-phosphorus-lyase-complex-subunit-PhnI
MGYVAIKGGETAITEAIKLLDVLRTQGASETPLTPGMIQHQLHALHSRVLSEGGLYHPDLAALAIKQSAGDTLEAAFFLRAYRSTCPRLGITLPHPTDSMRLVRRISAAFKDIPGGQMLGPTSDYLQRLFRFELLNESPEQFRQVVQDWFKTLPEHQLPTSFPKVLDSLRAEGLLPPVATESAPPAFDITREPLVFPVPRSAALATMARAETGSILAIAYSNMRGYGDVHPTVAELRVGYLPVYLPHPITGEPMEVGEVLMTECEVVAMYEAKDGEDLPTFGLGYGACLGHNEVKAIAMAVLDRALQKGQQHGADNPSEDSEFVLLHIDGIESMGFASHYKMPHYVTFQSDLDRLRTTQKQQRETVSS

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Crispr_ID: NC_019689_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_9

3254069-3254176

Orphan

Consensus_repeat	Method
AATATCAAATAGTAGTGCGGAGCTGCACGGCTTGCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019689_9

>merge|NC_019689|9|3254069-3254176|CRISPRCasFinder
AATATCAAATAGTAGTGCGGAGCTGCACGGCTTGCGACGTCGATATTAACACATTGGCTCAGGAATCTCAAATATCAAATAGTAGTGCGGAGCTGCACGGCTTGCGAC

>NC_019689|9|9|3254069-3254176|CRISPRCasFinder
AATATCAAATAGTAGTGCGGAGCTGCACGGCTTGCGAC	GTCGATATTAACACATTGGCTCAGGAATCTCA
AATATCAAATAGTAGTGCGGAGCTGCACGGCTTGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015144569.1\|3250217_3251657_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|235978
NC_019689.1\|WP_144266205.1\|3247234_3247918_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015144577.1\|3255878_3256787_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|178419
NC_019689.1\|WP_015144581.1\|3261298_3261595_-\|DUF1232-domain-containing-protein	unknown	unknown	gnl\|CDD\|225876
NC_019689.1\|WP_015144575.1\|3254316_3255402_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|279875
NC_019689.1\|WP_015144578.1\|3256991_3257639_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224929
NC_019689.1\|WP_015144580.1\|3260500_3261196_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|381154
NC_019689.1\|WP_015144571.1\|3252203_3252455_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015144579.1\|3257790_3260430_+\|chloride-channel-protein	unknown	unknown	gnl\|CDD\|238504
NC_019689.1\|WP_015144568.1\|3249885_3250221_+\|cation:proton-antiporter-subunit-C	unknown	unknown	gnl\|CDD\|236258
NC_019689.1\|WP_015144574.1\|3253345_3254008_+\|Na(+)/H(+)-antiporter-subunit-B	unknown	unknown	gnl\|CDD\|237140
NC_019689.1\|WP_015144573.1\|3252722_3253346_+\|DUF4040-domain-containing-protein	unknown	unknown	gnl\|CDD\|236006
NC_019689.1\|WP_015144584.1\|3264823_3265519_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_019689.1\|WP_041393353.1\|3264465_3264720_+\|YciI-family-protein	unknown	unknown	gnl\|CDD\|183801
NC_019689.1\|WP_015144570.1\|3251817_3252207_+\|Na+/H+-antiporter-subunit-E	unknown	unknown	unknown
NC_019689.1\|WP_041392178.1\|3255522_3255720_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015144582.1\|3261918_3263943_-\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|320697
NC_019689.1\|WP_015144572.1\|3252451_3252730_+\|monovalent-cation/H(+)-antiporter-subunit-G	unknown	unknown	gnl\|CDD\|377023
NC_019689.1\|WP_015144567.1\|3248012_3248297_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_186005325.1\|3249271_3249418_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|132848

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015144569.1\|3250217_3251657_+\|cation:proton-antiporter	gnl\|CDD\|235978	PRK07234, PRK07234, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0
NC_019689.1\|WP_015144577.1\|3255878_3256787_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|178419	PLN02824, PLN02824, hydrolase, alpha/beta fold family protein.	6.04561e-128
NC_019689.1\|WP_015144581.1\|3261298_3261595_-\|DUF1232-domain-containing-protein	gnl\|CDD\|225876	COG3339, COG3339, Uncharacterized conserved protein [Function unknown].	7.00286e-17
NC_019689.1\|WP_015144575.1\|3254316_3255402_+\|AI-2E-family-transporter	gnl\|CDD\|279875	pfam01594, AI-2E_transport, AI-2E family transporter. This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA, has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration of AI-2, TqsA affects gene expression in biofilms and biofilm formation. TsqA belongs to the AI-2 exporter (AI-2E) superfamily.	6.89321e-50
NC_019689.1\|WP_015144578.1\|3256991_3257639_+\|hypothetical-protein	gnl\|CDD\|224929	COG2018, COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only].	7.16314e-08
NC_019689.1\|WP_015144579.1\|3257790_3260430_+\|chloride-channel-protein	gnl\|CDD\|238504	cd01031, EriC, ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked proton utilization. As shown for Escherichia coli EriC, these channels can counterbalance the electric current produced by the outwardly directed virtual proton pump linked to amino acid decarboxylation. The EriC proteins belong to the ClC superfamily of chloride ion channels, which share a unique double-barreled architecture and voltage-dependent gating mechanism. The voltage-dependent gating is conferred by the permeating anion itself, acting as the gating charge. In Escherichia coli EriC, a glutamate residue that protrudes into the pore is thought to participate in gating by binding to a Cl- ion site within the selectivity filter.	8.99572e-140
NC_019689.1\|WP_015144572.1\|3252451_3252730_+\|monovalent-cation/H(+)-antiporter-subunit-G	gnl\|CDD\|377023	pfam03334, PhaG_MnhG_YufB, Na+/H+ antiporter subunit. This family includes PhaG from Rhizobium meliloti, MnhG from Staphylococcus aureus, YufB from Bacillus subtilis.	1.18342e-11
NC_019689.1\|WP_015144574.1\|3253345_3254008_+\|Na(+)/H(+)-antiporter-subunit-B	gnl\|CDD\|237140	PRK12567, PRK12567, putative monovalent cation/H+ antiporter subunit B; Reviewed.	2.57189e-103
NC_019689.1\|WP_015144573.1\|3252722_3253346_+\|DUF4040-domain-containing-protein	gnl\|CDD\|236006	PRK07377, PRK07377, hypothetical protein; Provisional.	7.54847e-90
NC_019689.1\|WP_015144584.1\|3264823_3265519_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.2111e-66
NC_019689.1\|WP_041393353.1\|3264465_3264720_+\|YciI-family-protein	gnl\|CDD\|183801	PRK12864, PRK12864, YciI-like protein; Reviewed.	8.27924e-57
NC_019689.1\|WP_015144580.1\|3260500_3261196_-\|response-regulator-transcription-factor	gnl\|CDD\|381154	cd19927, REC_Ycf29, phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29. Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.	1.16511e-54
NC_019689.1\|WP_015144582.1\|3261918_3263943_-\|M48-family-metalloprotease	gnl\|CDD\|320697	cd07338, M48B_HtpX_like, Peptidase M48 subfamily B HtpX-like membrane-bound metallopeptidase. This HtpX family of peptidase M48 subfamily B includes uncharacterized HtpX homologs and consists of proteins smaller than Ste24p, with homology restricted to the C-terminal half of Ste24p. HtpX expression is controlled by the Cpx stress response system, which senses abnormal membrane proteins. HtpX participates in the proteolytic quality control of these misfolded proteins by undergoing self-degradation and collaborating with FtsH, a membrane-bound and ATP-dependent protease, to eliminate them. HtpX, a zinc metalloprotease with an active site motif HEXXH, has an FtsH-like topology, and is capable of introducing endoproteolytic cleavages into SecY (also an FtsH substrate). However, HtpX does not have an ATPase activity and will only act against cytoplasmic regions of a target membrane protein. Thus, HtpX and FtsH have overlapping and/or complementary functions, which are especially important at high temperature; in E. coli and Xylella fastidiosa, HtpX is heat-inducible, while in Streptococcus gordonii it is not.	6.95833e-67
NC_019689.1\|WP_015144568.1\|3249885_3250221_+\|cation:proton-antiporter-subunit-C	gnl\|CDD\|236258	PRK08389, PRK08389, putative monovalent cation/H+ antiporter subunit C; Reviewed.	4.66071e-43
NC_019689.1\|WP_186005325.1\|3249271_3249418_-\|hypothetical-protein	gnl\|CDD\|132848	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli. Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	6.25637e-08

>NC_019689.1|WP_015144574.1|3253345_3254008_+|Na(+)/H(+)-antiporter-subunit-B
MKWIYIAAGILLYIKMMIMPNPASDGFDISIVEAVVRDSGVPNAVSGIIFRNRLYDTIFEVIVFTIAILGSYFLLANEKPTEKVYQFTDRPSIVLARLGATITSLVSIELAIRGHLSPGGGFAAGVAGGTAIGLIAITSPSEWMQGIYQRWQAATWEKVSVLIFIVLAAVTLLGLEFPDGELGTLVSGGIIPLLNILVAIKVALGSWAVVLLFIRYRGLL
>NC_019689.1|WP_015144573.1|3252722_3253346_+|DUF4040-domain-containing-protein
MTDSYIYVITALLPLTACMLVCQVNPYHALVIRGILGAVAALVYAVLGAADVALTEALVGTMLAITLYVVAVRSSLVMRIGILKDGTSEGSKSLQNGKGGCDFEELEELIDNLRTTISKYHLRLELVTYPDRRALNQGLIEKEIHATLTKSETWERDDQKCTVEEDERQPYQTAIGVRRLYEIMQSELSSSRTILTYVGAAKAQEKH
>NC_019689.1|WP_015144572.1|3252451_3252730_+|monovalent-cation/H(+)-antiporter-subunit-G
MIDLLGYICIGIGVIFWFWGTFPLIGNKSVLFKLHSLSVADTLGSMSIVIGLLLKIPREWPLLILAIITLAIWNTVLGYVLAYCSSSGGDND
>NC_019689.1|WP_015144571.1|3252203_3252455_+|hypothetical-protein
MSLLLITMILALLIPIYEACQDDDIWQKMLAFASIATKTSIVILMVSVLRDDWMIGVVAVIILSVGNAGLMLLAHLIKRMSEI
>NC_019689.1|WP_015144570.1|3251817_3252207_+|Na+/H+-antiporter-subunit-E
MIRYLDLILRLAIWFLLTADASLANIIIGVGIALLLPRSHTAPGALKDWLRTLWEIVVAIPKAYLEAVEIIFRPHNHEDVTMERVKPQRTPGLIFLDIFLITFTPKTIVLKYHEKGWYEVHRVRRRPPR
>NC_019689.1|WP_015144569.1|3250217_3251657_+|cation:proton-antiporter
MTNNITIAWLVLPFFIGFTLYLLPRLDRYLALGVAFVSAGYALELFFEESPLKLKLLDNFGVTLVADRLSGFFILTNALVTAAVLLYCWRSGKKAFFYMQTIILHGSVNATFICADLISLYVALEVISIAAFLLIAYPRTDRSIWVALRYLFVSNTAMLFYLVGAVLIYQAHHSFHFAGLRGSPPEAIALIFLGLLVKGGIFVSGLWLPLTHSESETPVSAMLSGVVVKAGVFPLVRCALLLEEIDPIVRFFGVGTALLGVFYAVFEKDTKRMLAFHTVSQLGFVLAAPVVGGFYALTHGLVKSALFLIAGILPSRNFKELQHQPIATPIWIALVIASFSISGFPLLSGFGAKVLTTKSLLPWQVVGMNLAALGTAISFAKFIFLPHERIEKKEEVQSGFWWAMTILLGGLIAANIVYYEAYTVNNIVKPLVTIAIGWLAYILFFKQTGIKLSRAIEQFDHQIGLMSLMLIFLFWMVWA
>NC_019689.1|WP_015144568.1|3249885_3250221_+|cation:proton-antiporter-subunit-C
MLEAFIFATILCGFFGIILKKNLVMKIVSMDVMSTGAIAYYVLIASRDGLFTPIISDVKNVAYSDPVPQAVILTAIVIGFSIQALMLVGVMKLARDNPTLESSEIEKSNTP
>NC_019689.1|WP_186005325.1|3249271_3249418_-|hypothetical-protein
MDLASCAIPNIFGAVEIGKDAYWDGIFSDNPPTDELTNPYYLTGWQLS
>NC_019689.1|WP_015144567.1|3248012_3248297_-|hypothetical-protein
MNKQKTRVRGFLIRSLTLSDRKSKIQKLQQARREFKNKSGKNYKQIYFSYPTKKGLGDRSDRLVFKLLYIVLDRTQEILLASIIGYVILILLVA
>NC_019689.1|WP_144266205.1|3247234_3247918_+|hypothetical-protein
MVVFFFTLAIASSVRSETPQQKGDPAAPNEALDLKPEIIEESSVLKRWLQEIPNVSEDIDGDPSFRTRIRLGYSQFPSSSDAGGLIIGVEDIFIGRTGLTFSGDYQASFNGDRESVGGNLHYYVLPLGSYFNLAPVLGYRYINSGDYSTDGVNVGIRLMLSLSRTGAADISLTQSFVSPGDSEEVGMTTLSVGYAIAKNVRLSADIQQQNSTQDKDSRVGIVIEWMP
>NC_019689.1|WP_015144575.1|3254316_3255402_+|AI-2E-family-transporter
METLPERQSTSDFRAVPAPLGKIPPWLRLGLIFPLIFLNGWLISLLINYLEPLLSILITASLLAFLLDFPILFLQKQGIPRKLAIALVLLLGLLVLVLLGLTLIPSIVQQLSDLVENLPVWIETGSQHVQTIQKWAIAQKLSIDLGDIVAQAAARVSNALRTLTSQLLSVLLSTINSLVNILLILGLAVFLVLTGESVWRGIFSWLPSPWDGRLRESIRQTFEAYFATQAILAGILSITQTIVFLLLDVPYAILFGFAIGMTTLIPYASTVTIAVISLLLALQNLQLGIKVLVAAIVIGQINDSVVAPRLMGGMTGLNPVWIIISLFIGGKLGGILGLLIAVPTASVIKSTTDTLRSPHSE
>NC_019689.1|WP_041392178.1|3255522_3255720_-|hypothetical-protein
MSAEQQARALMMRHHHAVKHRQQAMLERAASEIGVDVDNEYWTSIQGKAQPTFRKNYDRSHAALS
>NC_019689.1|WP_015144577.1|3255878_3256787_-|alpha/beta-fold-hydrolase
MKQLKNHRISDASPKIWTWKGFPICYQSVGEKGAAVVLIHGFGASWAHWRKNLPILGENCRCYAIDLIGFGGSAKPTPGVEIDYTFETWGQQVADFCREVVGSPVFLVGNSIGCIVAMQAAVDNPDLVLGVALLNCTLRLLHDRKRGQLLWYENLGSYILQQLLGNKLIGYLFFKQIARPEVVRKILRQAYCRQEAVTDELIDIIMQPTTDKGAADVFLAFTRYSYGPLPEDLLPLLSCPVLILWGTEDPWEPIELGRKLADFPAVQQFIPLEGVGHCPQDEAPEIVNPILQNWILSISQEG
>NC_019689.1|WP_015144578.1|3256991_3257639_+|hypothetical-protein
MNDRVDRILQEFASRSLEIEGAFLVSSQGQPITVAMGMEYNSALILAGTMLRLAQIVREEYAWQEIEQVSIRSQEGYVILFRCSKEVFLLVKTARVPWGFLDRDIHRTVKTLQSELQTTDIPRLTAEDSSQLTLLWEDRQIAASERAKTKFKLDGDFIARAQQELAQYIGPIASIVCKRVLAEKPNIDPSEFIEALAKHIPQQKQALNFQRHFLF
>NC_019689.1|WP_015144579.1|3257790_3260430_+|chloride-channel-protein
MELNTIPQRLRIWFKSLHFGRSSVDTRYALVEACLIGILSALAALWLKKGIGWLGGWRIQAAHQFGAWLVLPAVGLSFSLLAGWILQKFSPAAAGGGIPQVKAALARYPILLSLRVAVVKAIGTTLILGAGLTLGRRAPTVHIGAALAAQLSSWIPTSPEHRRQMIAAGAAAGLAAGFNTPIAGVLFVVEELMRDVSDLTLETAIVASFTGAVVSRLLDSADLNIPASLLDARSGSFSAPEIPFYLFLGALAGILGALFNRSMMFSLWVNRRSNLSLAWRIGIVGLLSGAIIAFLPPFFQDNSGLREFLVYGGLSWQNIAIAFVAHFFLTILAYSSGAPGGLFAPALVMGSALGYLVGDLAGWLSGINSESTYALAGMGAFFTAVGRVPVTAIVIVFEITADFNIVLPLMVTCAIAYIVAESISRGSIYEHLLKTSGIQLKQQETPRNDFLNKLTAADVMQSQVETLSSDLTLDETMLAVSRSHHRGFPVIEEGKLVGIITQSDLASLSQRSPQTLLKEIMTMRPITVKPDTSLSDVLYLLNRYQLSRLPVTEGSKLVGIITRTDIIRSEVNQLNQGTQRAFKPSPSYVAYQTRSPSVGKGRILLPIANPQTAPALMKIAAAIARYHQYELECLQIIKVPKHIFPSEAYVNTQESRKLLHRVERLGRQWNIPVHTQIRVAQDRAEAILEAIAKQQINILLMGWKGNTATPGAIFGDLVDTIIHRAPCDLILVKLGSSLNAYPNDLNQSATWLIPMAGGPNAQRAIELLPGLASLYSRIHSPKLWLCQVYSPATSALDCSLLEYSTDYLRNNLSLPVMPIAVRSRSVSDAVIRLAGEEKCSVVMLGASREGLLQHAIHGNIPEAIANKVESTTIIVRSAY
>NC_019689.1|WP_015144580.1|3260500_3261196_-|response-regulator-transcription-factor
MSEKAKLLLVDDEPGVRESVQAYLEDSGEFKVQLASNANEAWESIQHETPDLVISDIMMPQVDGYQFLKKLREDDRFKALPVVFLTARGMTSDRIQGYKAGCDAYVSKPFDPEELEAVVRNVLKRRQETVAASGEAAQLAEIVQDIKAIKEQLGQSSHLVPTPSPIKIELTPREQSVLDLVAEGLMNKEIAGRLDTSVRNVEKYVSRLFSKTGTNSRTELVRFALKHGLTT
>NC_019689.1|WP_015144581.1|3261298_3261595_-|DUF1232-domain-containing-protein
MKIPIQSIYNFYRNAIRNPKYRWWIILGTLVYLLSPFDISPDFFPIVGEIDDFILVTFLVTEVSQLILDRFKSTKTNPVAAPTETSNETIEVQAVSAE
>NC_019689.1|WP_015144582.1|3261918_3263943_-|M48-family-metalloprotease
MSLKDGLKALQQHRYSEAIELLAAYCQTASNPHSQEYAQVQMALARAYHGNGEKHKAIALCQELERYLDSQVSNWAKGFLSTLNKAETPREEAAAEAPKPLQKAGRAAQTGVRLVMKGFADNLALVSIATICLLFGMVLVLCLAILFILNSNDPFSGLAVAIIITLIFNTAAFFISPSMMDLTQEWFYQTHWVPLAEIERRSPEAAEVIKRVCREKNISLPRLGIIDDQNPTAFTYGSFPDSARLVVSQGLFTYLDDDEVATVYAHELGHIVHWDFAIMTVASTLVQISYLIYTFARNFSRGGNDNKIKNAIQVAAITAYVFYLVGTYLILYLSRTREYYADHFAAETTGNPNALSRALVKIAYGILEQGQRTQEPSKLIEGTRALGIYDSKAAVATGTAYRIASNSQQIGRVFLWDMFNPWGWWMEMNSTHPLTGKRIRALTTYAEQMGLETEFDMAAVVREGRKLNKNKLYGNLVLDILLFNAQWVSAIAGFLLGLLVALISSNASVLPSFSFFGFGIGTLINAFAMYPDFGRVSQTDIFTLMCDPYASPLRGRPVQLQGKLIGRADAAGYQFGSDLRLQDKMGTIYTRYASRFGSLGNFLFGATQVQKLIGSEVQAVGWFRREIIPRVDLVQLKTNRTTVRSYPRFWSLVMGIGAIIFGFIVPMLLQADLF
>NC_019689.1|WP_041393353.1|3264465_3264720_+|YciI-family-protein
MWGSYCENALEKRAPYRQDHLDGLAAQKEKGILITLGPTKDATKVFGIYEAEDEAIVRQVIESDPYWQNGIWTEYEVKEWIQAF
>NC_019689.1|WP_015144584.1|3264823_3265519_-|response-regulator-transcription-factor
MLSIATVLNPCILLVKTDEAFAQQASQDLIEAGYTTAIAPDIDKALLEIETLQPAMVVIDRALAGESGLRLCRQLRQKGDRVLIILSIDQETVEERVKCLEAGADDYLLKPYHSKEFLQMVRFYLHPREASKEQLRFGELVLDLTTRRLILGEQGIDLTMKEFELLKYLMSHPREVLSREQILENVWGYDFRGESNVIEVYIRYLRLKIENEGQKRLIHTVRGVGYVLRES

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Crispr_ID: NC_019689_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_10

3805338-3805444

TypeI-D

I-D,II-B

Consensus_repeat	Method
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas4,cas6,cas3,csc1gr5,csc2gr7,WYL,Cas14u_CAS-V

The CRISPR arrays of NC_019689_10

>merge|NC_019689|10|3805338-3805444|CRISPRCasFinder
TTTGAAAATCAACTAAATCCCTATCAGGGATTCCAGCCCCAGAGCTATCTAAGGATACTCCCGCAGTTTTTTGAAAATCAACTAAATCCCTATCAGGGATTCGATTG

>NC_019689|10|10|3805338-3805444|CRISPRCasFinder
TTTGAAAATCAACTAAATCCCTATCAGGGATTCCAGC	CCCAGAGCTATCTAAGGATACTCCCGCAGTTT
TTTGAAAATCAACTAAATCCCTATCAGGGATTCGATTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015145062.1\|3800032_3802312_+\|type-I-D-CRISPR-associated-helicase-Cas3'	cas3	cd09710_cas3_CAS-I-D	gnl\|CDD\|274457
NC_019689.1\|WP_015145066.1\|3805026_3805299_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_019689.1\|WP_051036454.1\|3809915_3810365_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145072.1\|3811911_3812898_-\|RNA-polymerase-sigma-factor,-RpoD/SigA-family	unknown	unknown	gnl\|CDD\|180321
NC_019689.1\|WP_015145065.1\|3804001_3805006_+\|type-I-D-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274976
NC_019689.1\|WP_186005331.1\|3806397_3806553_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235067
NC_019689.1\|WP_071880594.1\|3810438_3810846_+\|transposase	unknown	unknown	gnl\|CDD\|372298
NC_019689.1\|WP_015145073.1\|3812884_3813037_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145060.1\|3798134_3799169_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	gnl\|CDD\|375747
NC_019689.1\|WP_144266215.1\|3810957_3811458_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145070.1\|3809192_3809612_+\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	gnl\|CDD\|279710
NC_019689.1\|WP_015145063.1\|3802480_3803317_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NC_019689.1\|WP_015145069.1\|3808746_3809004_-\|DUF5132-domain-containing-protein	unknown	unknown	gnl\|CDD\|319213
NC_019689.1\|WP_015145064.1\|3803342_3803939_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NC_019689.1\|WP_015145057.1\|3792315_3793113_+\|sulfotransferase-family-2-domain-containing-protein	unknown	unknown	gnl\|CDD\|367564
NC_019689.1\|WP_015145067.1\|3806578_3807712_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	Cas14u_CAS-V	-	gnl\|CDD\|223747
NC_019689.1\|WP_015145059.1\|3794366_3795227_-\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_019689.1\|WP_015145061.1\|3799254_3800040_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	gnl\|CDD\|274458
NC_019689.1\|WP_015145068.1\|3808092_3808653_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145058.1\|3793183_3794329_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015145062.1\|3800032_3802312_+\|type-I-D-CRISPR-associated-helicase-Cas3'	gnl\|CDD\|274457	TIGR03158, cas3_cyano, CRISPR-associated helicase Cas3, subtype CYANO. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. It contains helicase motifs and appears to represent the Cas3 protein of the Cyano subtype of CRISPR/Cas system.	2.55725e-106
NC_019689.1\|WP_015145066.1\|3805026_3805299_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.56073e-35
NC_019689.1\|WP_015145072.1\|3811911_3812898_-\|RNA-polymerase-sigma-factor,-RpoD/SigA-family	gnl\|CDD\|180321	PRK05949, PRK05949, RNA polymerase sigma factor; Validated.	0
NC_019689.1\|WP_015145065.1\|3804001_3805006_+\|type-I-D-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274976	TIGR04093, hypothetical_protein_L8106_25395, CRISPR-associated endonuclease Cas1, subtype CYANO. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes a clade of Cas1 limited to the CYANO subtype of CRISPR/Cas system and most often the type found there.	5.10791e-160
NC_019689.1\|WP_186005331.1\|3806397_3806553_-\|hypothetical-protein	gnl\|CDD\|235067	PRK02759, PRK02759, bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE.	2.46794e-05
NC_019689.1\|WP_071880594.1\|3810438_3810846_+\|transposase	gnl\|CDD\|372298	pfam12762, DDE_Tnp_IS1595, ISXO2-like transposase domain. This domain probably functions as an integrase that is found in a wide variety of transposases, including ISXO2.	1.10104e-12
NC_019689.1\|WP_015145060.1\|3798134_3799169_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	gnl\|CDD\|375747	pfam18320, Csc2, Csc2 Crispr. The Csc2 Crispr family of proteins forms a core RNA recognition motif-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	1.24572e-169
NC_019689.1\|WP_015145070.1\|3809192_3809612_+\|ribbon-helix-helix-protein,-CopG-family	gnl\|CDD\|279710	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family. The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerization and not DNA binding as might have been expected.	0.00934816
NC_019689.1\|WP_015145063.1\|3802480_3803317_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.29707e-46
NC_019689.1\|WP_015145069.1\|3808746_3809004_-\|DUF5132-domain-containing-protein	gnl\|CDD\|319213	pfam17195, DUF5132, Protein of unknown function (DUF5132). Proteins in this family are uncharacterized, but have been identified as members of a gene cluster for the synthesis of Ansamitocin.	9.40802e-08
NC_019689.1\|WP_015145064.1\|3803342_3803939_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	6.12808e-52
NC_019689.1\|WP_015145057.1\|3792315_3793113_+\|sulfotransferase-family-2-domain-containing-protein	gnl\|CDD\|367564	pfam03567, Sulfotransfer_2, Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyzes the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyzes the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.	5.7061e-07
NC_019689.1\|WP_015145067.1\|3806578_3807712_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.00766e-25
NC_019689.1\|WP_015145059.1\|3794366_3795227_-\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	5.0809e-06
NC_019689.1\|WP_015145061.1\|3799254_3800040_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	gnl\|CDD\|274458	TIGR03159, cas_Csc1, CRISPR type I-D/CYANO-associated protein Csc1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. This family is designated Csc1 for CRISPR/Cas Subtype Cyano protein 1, as it is often the first gene upstream of the core cas genes, cas3-cas4-cas1-cas2.	5.44056e-66
NC_019689.1\|WP_015145058.1\|3793183_3794329_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.14565e-68

>NC_019689.1|WP_015145066.1|3805026_3805299_+|CRISPR-associated-endonuclease-Cas2
MYVVISYDISEDKRRTKVHNILKSYGQWMQYSIFECDLTETQYAKLRSRLSKLIQSETDSIRFYFLCGCCQGKVERIGGEQPRDETIFLV
>NC_019689.1|WP_015145065.1|3804001_3805006_+|type-I-D-CRISPR-associated-endonuclease-Cas1
MGTVYITQEDAFIGKTDERLNVKINKQQLLDVPMIKVDGVVILGRATVSPAVVNELLERHIPLSFLTGTGRYLGRLEPEMTKNIFVRKAQWLAAGESPQAIHIVRGFVRGKLKNYRNLLMRRRRECPDLDLDSSITKLEQAIAPIETTSTINSLRGLEGSGSAAYFGCFDRLIKETDFQFKTRNRRPPTDPVNALLSLGYSLLRHDVQSAVNIVGFDPYLGYLHVERYGRPSLALDLMEEFRPLVVDAVVLSALNQGKLTPNDFIAEPLSNAVSLTPDGLKIFLRLYEQKKQSKFKHPVLQRQCTYQESFEIQARLLAKYLMGETDKYPPLVLK
>NC_019689.1|WP_015145064.1|3803342_3803939_+|CRISPR-associated-protein-Cas4
MNAADYIPIASLNHYAYCPHRCWRMFCAGEFIDNQYTIEGTSLHERVHTLSEQNRENKWQIRAVWLKSERYQLIGKSDLLIEVESGQLCPVEYKRGNRGEWDNDELQVCAQSLCLEEMTEQEITTGYVYYAHSHQRQLVEISEELRAKTQATIEAVKTLLETGIMPKAIYSKRCQGCSLYSRCLPQAIDKVGRYQEPV
>NC_019689.1|WP_015145063.1|3802480_3803317_+|CRISPR-associated-endoribonuclease-Cas6
MPHSLVLNLLPLSPIFPGYLSGQHLHALFLTLVSSVDRELGDYLHNDRTDKAFTLSPLQIDCQRPSHCLQWEHAKPIPVGTPCWWRISLLDDTLFGKLTQLWLNLNLDRPWHLGSADLQITSILATGRSMHPWANACTYSQLYEQALETERTLMFALATPMAFRQGKYDSSLPTREVVFNSLLSRWNKYSGIEISSLSLDAIFPSFFDIRTEILVDSRSKLIGCVGEITYRILGEANSLTIKQINALADFALYAGMGRKTTMGMGMSRRLRPLNSSAS
>NC_019689.1|WP_015145062.1|3800032_3802312_+|type-I-D-CRISPR-associated-helicase-Cas3'
MANDKLRITLEAKSIAACVPLPEELSFMGRALQHQVDVFKRSLNHDIILDLAPTGTGKTRAGLTVLLHEPNKSAVYIAPTNALITQQTEAAEKFICGAGLPHVVKSVSAQEIKNWSSDRVGKRSGEKIYNLLRNPATVFPEVGANKPILLITNPDIFYYATFFAYNKYDKSNIASEFYSKFSTIIFDEFHLYNAKQLVSLFFYLALSFVFGFFQHGRRVVLLTATPDKACESALEDLEKQGVKIARIDGESTTANQLPSQTAVNLEIRPQLERQEWLLEIANEVEKRFREKPDHNGAVILDSKYNIDRLAILLKARGLQKSYGRITGSTPFQDRLSAAQKPIILATSTVDVGFNFEKTPEPSRQNLDWLIFSAKDRFSFWQRIGRVGRVLGKNETDICSEAIVYLPSKAWEQGITSLNCSGGRKELQQKLETIACLERPFLEIYWKSEAFLEIARPLLELEESLEKLPNINYIPKLYQAIQHILGGKRDWNYYRYRMKALKGAEEISNLRIEDIQKELQYIKGSRAFIKLFLKVKYPEHFEDLRAGITPIEAWEKEFKKYEDVSTELKEFAQLWRASYAPLFQFRETLFENLKIRDPHGFLLDESEETIVDTMHLLCYYEFTESNGAIEIINSVEQPYDLSFAWRYFGTIEELKNKELNKLTALANCRIQRSLKGAIKPTPLLTKLEKQFLPGVIIATEVNQGIIIQLSKQGLKSYPISVSCNDFEKTYTFFPGLSGILAIAMSGIKLKLPDDEDFYII
>NC_019689.1|WP_015145061.1|3799254_3800040_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1
MQQLELSLNPAKKTSRPTYTKAQLIELWCAEPVFFASRELSDTYYTEGVIGNYALAYGFGWARSPYRLTGAATGRPTYIEDLSPLDCYVLPAWSDKVSFRFERFNALSDAYWYEMTNNHVATSREDLPLKRTGKRPNTYRPSNFPQTGRLRAIERGNSFQTIVFGKRELPEYIRLGKFMSKVRVRILKDLEIVSLPMGKYDSKTYLNSADLPNINLLAFDLVNMPPVSLLKNLRFRGEAWQVGEFIVPANLKFCGGDRNNG
>NC_019689.1|WP_015145060.1|3798134_3799169_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2
MTIEKLTPFLAPTYENFPKGRTIGLVVLRTTHSETIFRTEGSGEPMCSEFVRAGIEDKNIISRLVMTKRKQVAPERRRGREFLRSHNLLYNSPKGDSICSLNTNAPCEMCIDCFLYGFAAGGEGAQKSRVWTEDAFSVLPSTELVGDRTINAIFENGTMRDENGKASTALNTSEYIKPGVHFLDIVTLKDVTADELRYVLGNILLTTRYGAVSSRVGRMENEILGVFGGIAELPSSLELVQAVHDRLKASGKPVEHPLNTNELISATKQAISTWIDKRGISMQLSEDELNNLIADVDRHLSPNEQENFLKRLDRSYENFRRLPAETETKKDKKKKASTTILGEA
>NC_019689.1|WP_015145059.1|3794366_3795227_-|WYL-domain-containing-protein
MGRKGQSITLSVSERDKKALEKLALEFGMTWGDRPNISKLIEAIARHHLQIAPNHDWTQNRIQVLETARQALVDLGKISEAREIAQILQERSELTIPQRAEIEQFLKNPQPTWRRQIDNFIHRQQPFRLSYRDAADRLWEYTIVHAQIRLLEAKREYLVCRCEEFEGNEDIDELSHNWTLRLDRIQEAAVVAIARPWEKDLERVAVEFHLSGRLAFAYHDDTGEDETIGDLEGNPPIRRVVRNIFSTFWFFRDISKYWEDCAIVSPEIVRDRVQEKVKAMSQQYSS
>NC_019689.1|WP_015145058.1|3793183_3794329_+|Gfo/Idh/MocA-family-oxidoreductase
MSTEQHKIGVAVVGTGFGQAIHIPGFQHHPRTEVVAVYNRDLGKAKAIADSHNIPYAYNQLEKILALPEVEAVSISTPPFLHYEMGKMALEAGKHLLLEKPMNMSAQETKELYHLAAKKGLVATADFEFRFVPGWQLLAEYLQQGYVGQTRLIKIDWLVASRANPERPWNWYSRKDMGGGALGAIGSHAFDYINWLFGSVQRLCANLTCAIKERPDPNAGGELKPVDADDTCLIILELADGTPCQLSISSVTYQGRGHWVEVYGDRATLVLGSDNLKDYIHGFRLMAAPAGKSLAEVEIPKRLAFPQVFTDGRLAPFIRVVDRWVESIDAGESLVPSLREGVYSQLLMDLTHQSNEHRCWVDVPDLDTFLSLAETQRRRED
>NC_019689.1|WP_015145057.1|3792315_3793113_+|sulfotransferase-family-2-domain-containing-protein
MNKPFLTEKIKNVIKIIAPEKPKIFFMHIPKTGGISVDNAIARFYKRSSYNVDPAFSKTASKILCNPENVSSRDYNMFVFRQYLALHEMVKGTKYISGHVRFNLDIWNAYHSQYAYITILRNPIKRYISQYFYDAFKKDEHARVSEDLPNYLRSNKGKERGHTYINYLSNAWPQENCSVQEKLKLAKDNLDKFQLVGFLEQIDVFIERFKNQFGLSLRIPHKNKNPISRPQVDDKMIQQIEEVCEPDIELYEYAKKKSLSEMLSL
>NC_019689.1|WP_186005331.1|3806397_3806553_-|hypothetical-protein
MICSEIEEAIQIAIAICPLVLVTVIDSYAIASEAADLFYHDLVSLAHIALQ
>NC_019689.1|WP_015145067.1|3806578_3807712_-|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MQETFRVFADACEYVNQEVPQKLTNELAMQSLVYQDVRARFGLSSQLAIHAIRRVSGNRKTAKQKGKPVKEFRPTSVTYDARTFSFRESDWTVSLTMVRKRERFRLHIGNYQRGLLKGQKPKTATFSLNADGEYYLNIQLESTPEPPKKTKKVLGVDLGRTDIAVTSDGDSFSGKDVTNVRNHHARVRASLQQKASRGTRSTRRRARRLLQRLSGKERRFQRHTNHVISKRIVQHGKTNNQVIALEDLTGIRESANEMPRTKKERRLSNSWAFYQLRQFLTYKAVKNSVKLILVNPASQTCHKCLHIHPVRGESYRSGKRFACGHCGWVGDADLNGAKNLEAMGCSINTPGGSELLSCSLSYSASGLLKTPSAYAVG
>NC_019689.1|WP_015145068.1|3808092_3808653_+|hypothetical-protein
MTAIDKNASQSHAAPLQKRIVSFLREHSEIETILAVALGLLVTRRFQLRGVKAVLINLLIINLIGQLLELLKQPDSGTSQRVREEKERTALQTVGSFGQYTILHAVPGRIRLRVPQLAQDRVFAQRLEELLADDENVVDVRINRDAASVAIKYQTREISDIELGWRLMNILNRAESEEQSVETAAH
>NC_019689.1|WP_015145069.1|3808746_3809004_-|DUF5132-domain-containing-protein
MFNRLKIFCQNNPGKAIAIGIGAVVLAPTLVPLLKPAAKASLKTGVLFYNKAKESLAETREILEDIVEEAKAEIAAEQMQKDEDD
>NC_019689.1|WP_015145070.1|3809192_3809612_+|ribbon-helix-helix-protein,-CopG-family
MNQNRDEATLEVNVPQAWIEQFETLANQSGRSASELVREALARYLDISGQQPATSLDRLSSELKTFKAELAELTQKVNALSEKSYLITTMSARLTTLERAISLGNLKQTTTSTPCQLMDTDDDDYDDEPDEILTDFLMG
>NC_019689.1|WP_051036454.1|3809915_3810365_+|hypothetical-protein
MEFPLNDLLNRDKCRQWILEHFHPDGLSCPNCKAGVEQARRFRTTHRSQLRVYRCRVCDHTYNLYSGTLLAQHHLRPERVVLLLRGILKGESTKSLAGELQLNYKTALTLPHQLQARAEQLQSQEPVPDTRTETDEMFQKAGEKRRAAS
>NC_019689.1|WP_071880594.1|3810438_3810846_+|transposase
MVGTVGRNSGQVRLRVVRNTTGEILVNHVHQFTVIESQLFTDESASYNHVIRPHATVCHSQHEWARDDEGDGLREVHVNTVEGMWTDMRNFLSSFKGVHQERLSGYVAIFEFKGNLKRICPAFIASLVTPHTSYL
>NC_019689.1|WP_144266215.1|3810957_3811458_-|hypothetical-protein
MAPILSLGLATIMAIPTLALSLEEKQLEREPSSDRASEVYFAEAASKKSPLADGIYLYGQSPEPEQIGQEYLVFRVQQGKVIGAVYLPRSEFNCFSGTVDSHRMNLSIVDPYNNAVYPYEIALQDLSPVASGDRLPRAVGLEGYHQISTISENDRRILDVCLQKYQ
>NC_019689.1|WP_015145072.1|3811911_3812898_-|RNA-polymerase-sigma-factor,-RpoD/SigA-family
MPTAKVNSNKQQPVFSADMVRTYLHEIGRVPLLTHEQEIVYGKQVQRMMTLLEKKEELASKLGHEPSLTEWANYVQLGEDELNRAIAQGNRAKRKMIEANLRLVVAIAKKYQKRNMEFLDLIQEGSLGLERGVEKFDPTKGYKFSTYAYWWIRQAITRAIAQQARTIRLPIHITEKLNKIKKTQRELAQQLGRSATPGEIAQALDLEPAQIREYLSMARQPVSLDVRVGDNQDTELSDLLEDEGISPDNYITQELLRQDLNNLMAELTPQQREVLSLRFGLEDGKELSLAKIGQRLNISRERVRQLEHQALAQLRRRRSNVREYIVAS
>NC_019689.1|WP_015145073.1|3812884_3813037_-|hypothetical-protein
MEETQSHTDFDLESLLLVLANKQNGFHQGIESTQTFCSFQGVITVQNAHC

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Crispr_ID: NC_019689_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_11

3805557-3806031

TypeI-D

NA:I-D,II-B

Consensus_repeat	Method
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	CRISPRCasFinder
TTTGAAAATCAACTAAATCCCTATC	CRT
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	PILER-CR

6 spacers

cas2,cas1,cas4,cas6,cas3,csc1gr5,csc2gr7,WYL,Cas14u_CAS-V

The CRISPR arrays of NC_019689_11

>merge|NC_019689|11|3805557-3806031|CRISPRCasFinder,CRT,PILER-CR
TTTGAAAATCAACTAAATCCCTATCGGGGATTGAAACGCTAGGGCTAGTCGAAGAACCTTTATCTAACCAAGAGCTGATTTTGAAAATCAACTAAATCCCTATCAGGGATTGAAACAACTTGCTTCGTTTCTGCTAGGGCTTGTGCCTTGTTTGAAAATCAACTAAATCCCTATCAGGGATTGAAACCACCTTCAAATACTGGGAATGGCAAGGGATACGCTTTGAAAATCAACTAAATCCCTATCAGGGATTGAAACGCCGCCACTATCTTCAGCCATCACTTGCAGGTAATCTTTTGAAAATCAACTAAATCCCTATCAGGGATTGAAACATTTGTGTTTAAAAATTTATTGCATCCATCACCGCTTTTGAAAATCAACTAAATCCCTATCAGGGATTGAAACATTGCAAGTACTTTTGCACGAGGAAATGCGGGATTTGAAAATCAACTAAATCCCTATGCCATAGAAGGGA

>NC_019689|11|11|3805557-3806031|CRISPRCasFinder
TTTGAAAATCAACTAAATCCCTATCGGGGATTGAAAC	GCTAGGGCTAGTCGAAGAACCTTTATCTAACCAAGAGCTGAT
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	AACTTGCTTCGTTTCTGCTAGGGCTTGTGCCTTG
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	CACCTTCAAATACTGGGAATGGCAAGGGATACGC
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	GCCGCCACTATCTTCAGCCATCACTTGCAGGTAATCT
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	ATTTGTGTTTAAAAATTTATTGCATCCATCACCGCT
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	ATTGCAAGTACTTTTGCACGAGGAAATGCGGGA
TTTGAAAATCAACTAAATCCCTATGCCATAGAAGGGA

>NC_019689|11|4|3805557-3806019|CRT
TTTGAAAATCAACTAAATCCCTATC	GGGGATTGAAACGCTAGGGCTAGTCGAAGAACCTTTATCTAACCAAGAGCTGAT
TTTGAAAATCAACTAAATCCCTATC	AGGGATTGAAACAACTTGCTTCGTTTCTGCTAGGGCTTGTGCCTTG
TTTGAAAATCAACTAAATCCCTATC	AGGGATTGAAACCACCTTCAAATACTGGGAATGGCAAGGGATACGC
TTTGAAAATCAACTAAATCCCTATC	AGGGATTGAAACGCCGCCACTATCTTCAGCCATCACTTGCAGGTAATCT
TTTGAAAATCAACTAAATCCCTATC	AGGGATTGAAACATTTGTGTTTAAAAATTTATTGCATCCATCACCGCT
TTTGAAAATCAACTAAATCCCTATC	AGGGATTGAAACATTGCAAGTACTTTTGCACGAGGAAATGCGGGA
TTTGAAAATCAACTAAATCCCTATG

>NC_019689|11|6|3805636-3805961|PILER-CR
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	AACTTGCTTCGTTTCTGCTAGGGCTTGTGCCTTG
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	CACCTTCAAATACTGGGAATGGCAAGGGATACGC
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	GCCGCCACTATCTTCAGCCATCACTTGCAGGTAATCT
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC	ATTTGTGTTTAAAAATTTATTGCATCCATCACCGCT
TTTGAAAATCAACTAAATCCCTATCAGGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015145062.1\|3800032_3802312_+\|type-I-D-CRISPR-associated-helicase-Cas3'	cas3	cd09710_cas3_CAS-I-D	gnl\|CDD\|274457
NC_019689.1\|WP_015145066.1\|3805026_3805299_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_019689.1\|WP_051036454.1\|3809915_3810365_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145072.1\|3811911_3812898_-\|RNA-polymerase-sigma-factor,-RpoD/SigA-family	unknown	unknown	gnl\|CDD\|180321
NC_019689.1\|WP_015145065.1\|3804001_3805006_+\|type-I-D-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274976
NC_019689.1\|WP_186005331.1\|3806397_3806553_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235067
NC_019689.1\|WP_071880594.1\|3810438_3810846_+\|transposase	unknown	unknown	gnl\|CDD\|372298
NC_019689.1\|WP_015145073.1\|3812884_3813037_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145060.1\|3798134_3799169_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	gnl\|CDD\|375747
NC_019689.1\|WP_144266215.1\|3810957_3811458_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145070.1\|3809192_3809612_+\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	gnl\|CDD\|279710
NC_019689.1\|WP_015145063.1\|3802480_3803317_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NC_019689.1\|WP_015145069.1\|3808746_3809004_-\|DUF5132-domain-containing-protein	unknown	unknown	gnl\|CDD\|319213
NC_019689.1\|WP_015145064.1\|3803342_3803939_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NC_019689.1\|WP_015145057.1\|3792315_3793113_+\|sulfotransferase-family-2-domain-containing-protein	unknown	unknown	gnl\|CDD\|367564
NC_019689.1\|WP_015145067.1\|3806578_3807712_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	Cas14u_CAS-V	-	gnl\|CDD\|223747
NC_019689.1\|WP_015145059.1\|3794366_3795227_-\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_019689.1\|WP_015145061.1\|3799254_3800040_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	gnl\|CDD\|274458
NC_019689.1\|WP_015145068.1\|3808092_3808653_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145058.1\|3793183_3794329_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015145062.1\|3800032_3802312_+\|type-I-D-CRISPR-associated-helicase-Cas3'	gnl\|CDD\|274457	TIGR03158, cas3_cyano, CRISPR-associated helicase Cas3, subtype CYANO. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. It contains helicase motifs and appears to represent the Cas3 protein of the Cyano subtype of CRISPR/Cas system.	2.55725e-106
NC_019689.1\|WP_015145066.1\|3805026_3805299_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.56073e-35
NC_019689.1\|WP_015145072.1\|3811911_3812898_-\|RNA-polymerase-sigma-factor,-RpoD/SigA-family	gnl\|CDD\|180321	PRK05949, PRK05949, RNA polymerase sigma factor; Validated.	0
NC_019689.1\|WP_015145065.1\|3804001_3805006_+\|type-I-D-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274976	TIGR04093, hypothetical_protein_L8106_25395, CRISPR-associated endonuclease Cas1, subtype CYANO. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes a clade of Cas1 limited to the CYANO subtype of CRISPR/Cas system and most often the type found there.	5.10791e-160
NC_019689.1\|WP_186005331.1\|3806397_3806553_-\|hypothetical-protein	gnl\|CDD\|235067	PRK02759, PRK02759, bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE.	2.46794e-05
NC_019689.1\|WP_071880594.1\|3810438_3810846_+\|transposase	gnl\|CDD\|372298	pfam12762, DDE_Tnp_IS1595, ISXO2-like transposase domain. This domain probably functions as an integrase that is found in a wide variety of transposases, including ISXO2.	1.10104e-12
NC_019689.1\|WP_015145060.1\|3798134_3799169_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	gnl\|CDD\|375747	pfam18320, Csc2, Csc2 Crispr. The Csc2 Crispr family of proteins forms a core RNA recognition motif-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	1.24572e-169
NC_019689.1\|WP_015145070.1\|3809192_3809612_+\|ribbon-helix-helix-protein,-CopG-family	gnl\|CDD\|279710	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family. The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerization and not DNA binding as might have been expected.	0.00934816
NC_019689.1\|WP_015145063.1\|3802480_3803317_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.29707e-46
NC_019689.1\|WP_015145069.1\|3808746_3809004_-\|DUF5132-domain-containing-protein	gnl\|CDD\|319213	pfam17195, DUF5132, Protein of unknown function (DUF5132). Proteins in this family are uncharacterized, but have been identified as members of a gene cluster for the synthesis of Ansamitocin.	9.40802e-08
NC_019689.1\|WP_015145064.1\|3803342_3803939_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	6.12808e-52
NC_019689.1\|WP_015145057.1\|3792315_3793113_+\|sulfotransferase-family-2-domain-containing-protein	gnl\|CDD\|367564	pfam03567, Sulfotransfer_2, Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyzes the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyzes the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.	5.7061e-07
NC_019689.1\|WP_015145067.1\|3806578_3807712_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.00766e-25
NC_019689.1\|WP_015145059.1\|3794366_3795227_-\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	5.0809e-06
NC_019689.1\|WP_015145061.1\|3799254_3800040_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	gnl\|CDD\|274458	TIGR03159, cas_Csc1, CRISPR type I-D/CYANO-associated protein Csc1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. This family is designated Csc1 for CRISPR/Cas Subtype Cyano protein 1, as it is often the first gene upstream of the core cas genes, cas3-cas4-cas1-cas2.	5.44056e-66
NC_019689.1\|WP_015145058.1\|3793183_3794329_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.14565e-68

>NC_019689.1|WP_015145066.1|3805026_3805299_+|CRISPR-associated-endonuclease-Cas2
MYVVISYDISEDKRRTKVHNILKSYGQWMQYSIFECDLTETQYAKLRSRLSKLIQSETDSIRFYFLCGCCQGKVERIGGEQPRDETIFLV
>NC_019689.1|WP_015145065.1|3804001_3805006_+|type-I-D-CRISPR-associated-endonuclease-Cas1
MGTVYITQEDAFIGKTDERLNVKINKQQLLDVPMIKVDGVVILGRATVSPAVVNELLERHIPLSFLTGTGRYLGRLEPEMTKNIFVRKAQWLAAGESPQAIHIVRGFVRGKLKNYRNLLMRRRRECPDLDLDSSITKLEQAIAPIETTSTINSLRGLEGSGSAAYFGCFDRLIKETDFQFKTRNRRPPTDPVNALLSLGYSLLRHDVQSAVNIVGFDPYLGYLHVERYGRPSLALDLMEEFRPLVVDAVVLSALNQGKLTPNDFIAEPLSNAVSLTPDGLKIFLRLYEQKKQSKFKHPVLQRQCTYQESFEIQARLLAKYLMGETDKYPPLVLK
>NC_019689.1|WP_015145064.1|3803342_3803939_+|CRISPR-associated-protein-Cas4
MNAADYIPIASLNHYAYCPHRCWRMFCAGEFIDNQYTIEGTSLHERVHTLSEQNRENKWQIRAVWLKSERYQLIGKSDLLIEVESGQLCPVEYKRGNRGEWDNDELQVCAQSLCLEEMTEQEITTGYVYYAHSHQRQLVEISEELRAKTQATIEAVKTLLETGIMPKAIYSKRCQGCSLYSRCLPQAIDKVGRYQEPV
>NC_019689.1|WP_015145063.1|3802480_3803317_+|CRISPR-associated-endoribonuclease-Cas6
MPHSLVLNLLPLSPIFPGYLSGQHLHALFLTLVSSVDRELGDYLHNDRTDKAFTLSPLQIDCQRPSHCLQWEHAKPIPVGTPCWWRISLLDDTLFGKLTQLWLNLNLDRPWHLGSADLQITSILATGRSMHPWANACTYSQLYEQALETERTLMFALATPMAFRQGKYDSSLPTREVVFNSLLSRWNKYSGIEISSLSLDAIFPSFFDIRTEILVDSRSKLIGCVGEITYRILGEANSLTIKQINALADFALYAGMGRKTTMGMGMSRRLRPLNSSAS
>NC_019689.1|WP_015145062.1|3800032_3802312_+|type-I-D-CRISPR-associated-helicase-Cas3'
MANDKLRITLEAKSIAACVPLPEELSFMGRALQHQVDVFKRSLNHDIILDLAPTGTGKTRAGLTVLLHEPNKSAVYIAPTNALITQQTEAAEKFICGAGLPHVVKSVSAQEIKNWSSDRVGKRSGEKIYNLLRNPATVFPEVGANKPILLITNPDIFYYATFFAYNKYDKSNIASEFYSKFSTIIFDEFHLYNAKQLVSLFFYLALSFVFGFFQHGRRVVLLTATPDKACESALEDLEKQGVKIARIDGESTTANQLPSQTAVNLEIRPQLERQEWLLEIANEVEKRFREKPDHNGAVILDSKYNIDRLAILLKARGLQKSYGRITGSTPFQDRLSAAQKPIILATSTVDVGFNFEKTPEPSRQNLDWLIFSAKDRFSFWQRIGRVGRVLGKNETDICSEAIVYLPSKAWEQGITSLNCSGGRKELQQKLETIACLERPFLEIYWKSEAFLEIARPLLELEESLEKLPNINYIPKLYQAIQHILGGKRDWNYYRYRMKALKGAEEISNLRIEDIQKELQYIKGSRAFIKLFLKVKYPEHFEDLRAGITPIEAWEKEFKKYEDVSTELKEFAQLWRASYAPLFQFRETLFENLKIRDPHGFLLDESEETIVDTMHLLCYYEFTESNGAIEIINSVEQPYDLSFAWRYFGTIEELKNKELNKLTALANCRIQRSLKGAIKPTPLLTKLEKQFLPGVIIATEVNQGIIIQLSKQGLKSYPISVSCNDFEKTYTFFPGLSGILAIAMSGIKLKLPDDEDFYII
>NC_019689.1|WP_015145061.1|3799254_3800040_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1
MQQLELSLNPAKKTSRPTYTKAQLIELWCAEPVFFASRELSDTYYTEGVIGNYALAYGFGWARSPYRLTGAATGRPTYIEDLSPLDCYVLPAWSDKVSFRFERFNALSDAYWYEMTNNHVATSREDLPLKRTGKRPNTYRPSNFPQTGRLRAIERGNSFQTIVFGKRELPEYIRLGKFMSKVRVRILKDLEIVSLPMGKYDSKTYLNSADLPNINLLAFDLVNMPPVSLLKNLRFRGEAWQVGEFIVPANLKFCGGDRNNG
>NC_019689.1|WP_015145060.1|3798134_3799169_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2
MTIEKLTPFLAPTYENFPKGRTIGLVVLRTTHSETIFRTEGSGEPMCSEFVRAGIEDKNIISRLVMTKRKQVAPERRRGREFLRSHNLLYNSPKGDSICSLNTNAPCEMCIDCFLYGFAAGGEGAQKSRVWTEDAFSVLPSTELVGDRTINAIFENGTMRDENGKASTALNTSEYIKPGVHFLDIVTLKDVTADELRYVLGNILLTTRYGAVSSRVGRMENEILGVFGGIAELPSSLELVQAVHDRLKASGKPVEHPLNTNELISATKQAISTWIDKRGISMQLSEDELNNLIADVDRHLSPNEQENFLKRLDRSYENFRRLPAETETKKDKKKKASTTILGEA
>NC_019689.1|WP_015145059.1|3794366_3795227_-|WYL-domain-containing-protein
MGRKGQSITLSVSERDKKALEKLALEFGMTWGDRPNISKLIEAIARHHLQIAPNHDWTQNRIQVLETARQALVDLGKISEAREIAQILQERSELTIPQRAEIEQFLKNPQPTWRRQIDNFIHRQQPFRLSYRDAADRLWEYTIVHAQIRLLEAKREYLVCRCEEFEGNEDIDELSHNWTLRLDRIQEAAVVAIARPWEKDLERVAVEFHLSGRLAFAYHDDTGEDETIGDLEGNPPIRRVVRNIFSTFWFFRDISKYWEDCAIVSPEIVRDRVQEKVKAMSQQYSS
>NC_019689.1|WP_015145058.1|3793183_3794329_+|Gfo/Idh/MocA-family-oxidoreductase
MSTEQHKIGVAVVGTGFGQAIHIPGFQHHPRTEVVAVYNRDLGKAKAIADSHNIPYAYNQLEKILALPEVEAVSISTPPFLHYEMGKMALEAGKHLLLEKPMNMSAQETKELYHLAAKKGLVATADFEFRFVPGWQLLAEYLQQGYVGQTRLIKIDWLVASRANPERPWNWYSRKDMGGGALGAIGSHAFDYINWLFGSVQRLCANLTCAIKERPDPNAGGELKPVDADDTCLIILELADGTPCQLSISSVTYQGRGHWVEVYGDRATLVLGSDNLKDYIHGFRLMAAPAGKSLAEVEIPKRLAFPQVFTDGRLAPFIRVVDRWVESIDAGESLVPSLREGVYSQLLMDLTHQSNEHRCWVDVPDLDTFLSLAETQRRRED
>NC_019689.1|WP_015145057.1|3792315_3793113_+|sulfotransferase-family-2-domain-containing-protein
MNKPFLTEKIKNVIKIIAPEKPKIFFMHIPKTGGISVDNAIARFYKRSSYNVDPAFSKTASKILCNPENVSSRDYNMFVFRQYLALHEMVKGTKYISGHVRFNLDIWNAYHSQYAYITILRNPIKRYISQYFYDAFKKDEHARVSEDLPNYLRSNKGKERGHTYINYLSNAWPQENCSVQEKLKLAKDNLDKFQLVGFLEQIDVFIERFKNQFGLSLRIPHKNKNPISRPQVDDKMIQQIEEVCEPDIELYEYAKKKSLSEMLSL
>NC_019689.1|WP_186005331.1|3806397_3806553_-|hypothetical-protein
MICSEIEEAIQIAIAICPLVLVTVIDSYAIASEAADLFYHDLVSLAHIALQ
>NC_019689.1|WP_015145067.1|3806578_3807712_-|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MQETFRVFADACEYVNQEVPQKLTNELAMQSLVYQDVRARFGLSSQLAIHAIRRVSGNRKTAKQKGKPVKEFRPTSVTYDARTFSFRESDWTVSLTMVRKRERFRLHIGNYQRGLLKGQKPKTATFSLNADGEYYLNIQLESTPEPPKKTKKVLGVDLGRTDIAVTSDGDSFSGKDVTNVRNHHARVRASLQQKASRGTRSTRRRARRLLQRLSGKERRFQRHTNHVISKRIVQHGKTNNQVIALEDLTGIRESANEMPRTKKERRLSNSWAFYQLRQFLTYKAVKNSVKLILVNPASQTCHKCLHIHPVRGESYRSGKRFACGHCGWVGDADLNGAKNLEAMGCSINTPGGSELLSCSLSYSASGLLKTPSAYAVG
>NC_019689.1|WP_015145068.1|3808092_3808653_+|hypothetical-protein
MTAIDKNASQSHAAPLQKRIVSFLREHSEIETILAVALGLLVTRRFQLRGVKAVLINLLIINLIGQLLELLKQPDSGTSQRVREEKERTALQTVGSFGQYTILHAVPGRIRLRVPQLAQDRVFAQRLEELLADDENVVDVRINRDAASVAIKYQTREISDIELGWRLMNILNRAESEEQSVETAAH
>NC_019689.1|WP_015145069.1|3808746_3809004_-|DUF5132-domain-containing-protein
MFNRLKIFCQNNPGKAIAIGIGAVVLAPTLVPLLKPAAKASLKTGVLFYNKAKESLAETREILEDIVEEAKAEIAAEQMQKDEDD
>NC_019689.1|WP_015145070.1|3809192_3809612_+|ribbon-helix-helix-protein,-CopG-family
MNQNRDEATLEVNVPQAWIEQFETLANQSGRSASELVREALARYLDISGQQPATSLDRLSSELKTFKAELAELTQKVNALSEKSYLITTMSARLTTLERAISLGNLKQTTTSTPCQLMDTDDDDYDDEPDEILTDFLMG
>NC_019689.1|WP_051036454.1|3809915_3810365_+|hypothetical-protein
MEFPLNDLLNRDKCRQWILEHFHPDGLSCPNCKAGVEQARRFRTTHRSQLRVYRCRVCDHTYNLYSGTLLAQHHLRPERVVLLLRGILKGESTKSLAGELQLNYKTALTLPHQLQARAEQLQSQEPVPDTRTETDEMFQKAGEKRRAAS
>NC_019689.1|WP_071880594.1|3810438_3810846_+|transposase
MVGTVGRNSGQVRLRVVRNTTGEILVNHVHQFTVIESQLFTDESASYNHVIRPHATVCHSQHEWARDDEGDGLREVHVNTVEGMWTDMRNFLSSFKGVHQERLSGYVAIFEFKGNLKRICPAFIASLVTPHTSYL
>NC_019689.1|WP_144266215.1|3810957_3811458_-|hypothetical-protein
MAPILSLGLATIMAIPTLALSLEEKQLEREPSSDRASEVYFAEAASKKSPLADGIYLYGQSPEPEQIGQEYLVFRVQQGKVIGAVYLPRSEFNCFSGTVDSHRMNLSIVDPYNNAVYPYEIALQDLSPVASGDRLPRAVGLEGYHQISTISENDRRILDVCLQKYQ
>NC_019689.1|WP_015145072.1|3811911_3812898_-|RNA-polymerase-sigma-factor,-RpoD/SigA-family
MPTAKVNSNKQQPVFSADMVRTYLHEIGRVPLLTHEQEIVYGKQVQRMMTLLEKKEELASKLGHEPSLTEWANYVQLGEDELNRAIAQGNRAKRKMIEANLRLVVAIAKKYQKRNMEFLDLIQEGSLGLERGVEKFDPTKGYKFSTYAYWWIRQAITRAIAQQARTIRLPIHITEKLNKIKKTQRELAQQLGRSATPGEIAQALDLEPAQIREYLSMARQPVSLDVRVGDNQDTELSDLLEDEGISPDNYITQELLRQDLNNLMAELTPQQREVLSLRFGLEDGKELSLAKIGQRLNISRERVRQLEHQALAQLRRRRSNVREYIVAS
>NC_019689.1|WP_015145073.1|3812884_3813037_-|hypothetical-protein
MEETQSHTDFDLESLLLVLANKQNGFHQGIESTQTFCSFQGVITVQNAHC

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Crispr_ID: NC_019689_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_12

3807693-3807798

TypeI-D

Consensus_repeat	Method
ACCCGGAACGTTTCTTGCACTTTGGCAAGCTGTTCG	CRISPRCasFinder

1 spacers

cas2,cas1,cas4,cas6,cas3,csc1gr5,csc2gr7,WYL

The CRISPR arrays of NC_019689_12

>merge|NC_019689|12|3807693-3807798|CRISPRCasFinder
ACCCGGAACGTTTCTTGCACTTTGGCAAGCTGTTCGTGAAATTTTCAAAAAAGCCGTTACAGGGGGCATTACCCGGAACGTTTCTTGCACTTTGGCAAGCTGTTCG

>NC_019689|12|12|3807693-3807798|CRISPRCasFinder
ACCCGGAACGTTTCTTGCACTTTGGCAAGCTGTTCG	TGAAATTTTCAAAAAAGCCGTTACAGGGGGCATT
ACCCGGAACGTTTCTTGCACTTTGGCAAGCTGTTCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015145062.1\|3800032_3802312_+\|type-I-D-CRISPR-associated-helicase-Cas3'	cas3	cd09710_cas3_CAS-I-D	gnl\|CDD\|274457
NC_019689.1\|WP_015145066.1\|3805026_3805299_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_019689.1\|WP_051036454.1\|3809915_3810365_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145072.1\|3811911_3812898_-\|RNA-polymerase-sigma-factor,-RpoD/SigA-family	unknown	unknown	gnl\|CDD\|180321
NC_019689.1\|WP_015145065.1\|3804001_3805006_+\|type-I-D-CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274976
NC_019689.1\|WP_186005331.1\|3806397_3806553_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235067
NC_019689.1\|WP_144266215.1\|3810957_3811458_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145073.1\|3812884_3813037_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145060.1\|3798134_3799169_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	gnl\|CDD\|375747
NC_019689.1\|WP_144266216.1\|3813760_3814480_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_019689.1\|WP_015145070.1\|3809192_3809612_+\|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	gnl\|CDD\|279710
NC_019689.1\|WP_015145063.1\|3802480_3803317_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NC_019689.1\|WP_015145069.1\|3808746_3809004_-\|DUF5132-domain-containing-protein	unknown	unknown	gnl\|CDD\|319213
NC_019689.1\|WP_015145064.1\|3803342_3803939_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NC_019689.1\|WP_071880594.1\|3810438_3810846_+\|transposase	unknown	unknown	gnl\|CDD\|372298
NC_019689.1\|WP_015145059.1\|3794366_3795227_-\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_019689.1\|WP_015145074.1\|3813502_3813682_+\|ssl1498-family-light-harvesting-like-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145061.1\|3799254_3800040_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	gnl\|CDD\|274458
NC_019689.1\|WP_015145068.1\|3808092_3808653_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145058.1\|3793183_3794329_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015145062.1\|3800032_3802312_+\|type-I-D-CRISPR-associated-helicase-Cas3'	gnl\|CDD\|274457	TIGR03158, cas3_cyano, CRISPR-associated helicase Cas3, subtype CYANO. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. It contains helicase motifs and appears to represent the Cas3 protein of the Cyano subtype of CRISPR/Cas system.	2.55725e-106
NC_019689.1\|WP_015145066.1\|3805026_3805299_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.56073e-35
NC_019689.1\|WP_015145072.1\|3811911_3812898_-\|RNA-polymerase-sigma-factor,-RpoD/SigA-family	gnl\|CDD\|180321	PRK05949, PRK05949, RNA polymerase sigma factor; Validated.	0
NC_019689.1\|WP_015145065.1\|3804001_3805006_+\|type-I-D-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274976	TIGR04093, hypothetical_protein_L8106_25395, CRISPR-associated endonuclease Cas1, subtype CYANO. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes a clade of Cas1 limited to the CYANO subtype of CRISPR/Cas system and most often the type found there.	5.10791e-160
NC_019689.1\|WP_186005331.1\|3806397_3806553_-\|hypothetical-protein	gnl\|CDD\|235067	PRK02759, PRK02759, bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE.	2.46794e-05
NC_019689.1\|WP_015145060.1\|3798134_3799169_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	gnl\|CDD\|375747	pfam18320, Csc2, Csc2 Crispr. The Csc2 Crispr family of proteins forms a core RNA recognition motif-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	1.24572e-169
NC_019689.1\|WP_144266216.1\|3813760_3814480_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.01125e-19
NC_019689.1\|WP_015145070.1\|3809192_3809612_+\|ribbon-helix-helix-protein,-CopG-family	gnl\|CDD\|279710	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family. The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerization and not DNA binding as might have been expected.	0.00934816
NC_019689.1\|WP_015145063.1\|3802480_3803317_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.29707e-46
NC_019689.1\|WP_015145069.1\|3808746_3809004_-\|DUF5132-domain-containing-protein	gnl\|CDD\|319213	pfam17195, DUF5132, Protein of unknown function (DUF5132). Proteins in this family are uncharacterized, but have been identified as members of a gene cluster for the synthesis of Ansamitocin.	9.40802e-08
NC_019689.1\|WP_015145064.1\|3803342_3803939_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	6.12808e-52
NC_019689.1\|WP_071880594.1\|3810438_3810846_+\|transposase	gnl\|CDD\|372298	pfam12762, DDE_Tnp_IS1595, ISXO2-like transposase domain. This domain probably functions as an integrase that is found in a wide variety of transposases, including ISXO2.	1.10104e-12
NC_019689.1\|WP_015145059.1\|3794366_3795227_-\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	5.0809e-06
NC_019689.1\|WP_015145061.1\|3799254_3800040_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	gnl\|CDD\|274458	TIGR03159, cas_Csc1, CRISPR type I-D/CYANO-associated protein Csc1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. This family is designated Csc1 for CRISPR/Cas Subtype Cyano protein 1, as it is often the first gene upstream of the core cas genes, cas3-cas4-cas1-cas2.	5.44056e-66
NC_019689.1\|WP_015145058.1\|3793183_3794329_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.14565e-68

>NC_019689.1|WP_186005331.1|3806397_3806553_-|hypothetical-protein
MICSEIEEAIQIAIAICPLVLVTVIDSYAIASEAADLFYHDLVSLAHIALQ
>NC_019689.1|WP_015145066.1|3805026_3805299_+|CRISPR-associated-endonuclease-Cas2
MYVVISYDISEDKRRTKVHNILKSYGQWMQYSIFECDLTETQYAKLRSRLSKLIQSETDSIRFYFLCGCCQGKVERIGGEQPRDETIFLV
>NC_019689.1|WP_015145065.1|3804001_3805006_+|type-I-D-CRISPR-associated-endonuclease-Cas1
MGTVYITQEDAFIGKTDERLNVKINKQQLLDVPMIKVDGVVILGRATVSPAVVNELLERHIPLSFLTGTGRYLGRLEPEMTKNIFVRKAQWLAAGESPQAIHIVRGFVRGKLKNYRNLLMRRRRECPDLDLDSSITKLEQAIAPIETTSTINSLRGLEGSGSAAYFGCFDRLIKETDFQFKTRNRRPPTDPVNALLSLGYSLLRHDVQSAVNIVGFDPYLGYLHVERYGRPSLALDLMEEFRPLVVDAVVLSALNQGKLTPNDFIAEPLSNAVSLTPDGLKIFLRLYEQKKQSKFKHPVLQRQCTYQESFEIQARLLAKYLMGETDKYPPLVLK
>NC_019689.1|WP_015145064.1|3803342_3803939_+|CRISPR-associated-protein-Cas4
MNAADYIPIASLNHYAYCPHRCWRMFCAGEFIDNQYTIEGTSLHERVHTLSEQNRENKWQIRAVWLKSERYQLIGKSDLLIEVESGQLCPVEYKRGNRGEWDNDELQVCAQSLCLEEMTEQEITTGYVYYAHSHQRQLVEISEELRAKTQATIEAVKTLLETGIMPKAIYSKRCQGCSLYSRCLPQAIDKVGRYQEPV
>NC_019689.1|WP_015145063.1|3802480_3803317_+|CRISPR-associated-endoribonuclease-Cas6
MPHSLVLNLLPLSPIFPGYLSGQHLHALFLTLVSSVDRELGDYLHNDRTDKAFTLSPLQIDCQRPSHCLQWEHAKPIPVGTPCWWRISLLDDTLFGKLTQLWLNLNLDRPWHLGSADLQITSILATGRSMHPWANACTYSQLYEQALETERTLMFALATPMAFRQGKYDSSLPTREVVFNSLLSRWNKYSGIEISSLSLDAIFPSFFDIRTEILVDSRSKLIGCVGEITYRILGEANSLTIKQINALADFALYAGMGRKTTMGMGMSRRLRPLNSSAS
>NC_019689.1|WP_015145062.1|3800032_3802312_+|type-I-D-CRISPR-associated-helicase-Cas3'
MANDKLRITLEAKSIAACVPLPEELSFMGRALQHQVDVFKRSLNHDIILDLAPTGTGKTRAGLTVLLHEPNKSAVYIAPTNALITQQTEAAEKFICGAGLPHVVKSVSAQEIKNWSSDRVGKRSGEKIYNLLRNPATVFPEVGANKPILLITNPDIFYYATFFAYNKYDKSNIASEFYSKFSTIIFDEFHLYNAKQLVSLFFYLALSFVFGFFQHGRRVVLLTATPDKACESALEDLEKQGVKIARIDGESTTANQLPSQTAVNLEIRPQLERQEWLLEIANEVEKRFREKPDHNGAVILDSKYNIDRLAILLKARGLQKSYGRITGSTPFQDRLSAAQKPIILATSTVDVGFNFEKTPEPSRQNLDWLIFSAKDRFSFWQRIGRVGRVLGKNETDICSEAIVYLPSKAWEQGITSLNCSGGRKELQQKLETIACLERPFLEIYWKSEAFLEIARPLLELEESLEKLPNINYIPKLYQAIQHILGGKRDWNYYRYRMKALKGAEEISNLRIEDIQKELQYIKGSRAFIKLFLKVKYPEHFEDLRAGITPIEAWEKEFKKYEDVSTELKEFAQLWRASYAPLFQFRETLFENLKIRDPHGFLLDESEETIVDTMHLLCYYEFTESNGAIEIINSVEQPYDLSFAWRYFGTIEELKNKELNKLTALANCRIQRSLKGAIKPTPLLTKLEKQFLPGVIIATEVNQGIIIQLSKQGLKSYPISVSCNDFEKTYTFFPGLSGILAIAMSGIKLKLPDDEDFYII
>NC_019689.1|WP_015145061.1|3799254_3800040_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1
MQQLELSLNPAKKTSRPTYTKAQLIELWCAEPVFFASRELSDTYYTEGVIGNYALAYGFGWARSPYRLTGAATGRPTYIEDLSPLDCYVLPAWSDKVSFRFERFNALSDAYWYEMTNNHVATSREDLPLKRTGKRPNTYRPSNFPQTGRLRAIERGNSFQTIVFGKRELPEYIRLGKFMSKVRVRILKDLEIVSLPMGKYDSKTYLNSADLPNINLLAFDLVNMPPVSLLKNLRFRGEAWQVGEFIVPANLKFCGGDRNNG
>NC_019689.1|WP_015145060.1|3798134_3799169_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2
MTIEKLTPFLAPTYENFPKGRTIGLVVLRTTHSETIFRTEGSGEPMCSEFVRAGIEDKNIISRLVMTKRKQVAPERRRGREFLRSHNLLYNSPKGDSICSLNTNAPCEMCIDCFLYGFAAGGEGAQKSRVWTEDAFSVLPSTELVGDRTINAIFENGTMRDENGKASTALNTSEYIKPGVHFLDIVTLKDVTADELRYVLGNILLTTRYGAVSSRVGRMENEILGVFGGIAELPSSLELVQAVHDRLKASGKPVEHPLNTNELISATKQAISTWIDKRGISMQLSEDELNNLIADVDRHLSPNEQENFLKRLDRSYENFRRLPAETETKKDKKKKASTTILGEA
>NC_019689.1|WP_015145059.1|3794366_3795227_-|WYL-domain-containing-protein
MGRKGQSITLSVSERDKKALEKLALEFGMTWGDRPNISKLIEAIARHHLQIAPNHDWTQNRIQVLETARQALVDLGKISEAREIAQILQERSELTIPQRAEIEQFLKNPQPTWRRQIDNFIHRQQPFRLSYRDAADRLWEYTIVHAQIRLLEAKREYLVCRCEEFEGNEDIDELSHNWTLRLDRIQEAAVVAIARPWEKDLERVAVEFHLSGRLAFAYHDDTGEDETIGDLEGNPPIRRVVRNIFSTFWFFRDISKYWEDCAIVSPEIVRDRVQEKVKAMSQQYSS
>NC_019689.1|WP_015145058.1|3793183_3794329_+|Gfo/Idh/MocA-family-oxidoreductase
MSTEQHKIGVAVVGTGFGQAIHIPGFQHHPRTEVVAVYNRDLGKAKAIADSHNIPYAYNQLEKILALPEVEAVSISTPPFLHYEMGKMALEAGKHLLLEKPMNMSAQETKELYHLAAKKGLVATADFEFRFVPGWQLLAEYLQQGYVGQTRLIKIDWLVASRANPERPWNWYSRKDMGGGALGAIGSHAFDYINWLFGSVQRLCANLTCAIKERPDPNAGGELKPVDADDTCLIILELADGTPCQLSISSVTYQGRGHWVEVYGDRATLVLGSDNLKDYIHGFRLMAAPAGKSLAEVEIPKRLAFPQVFTDGRLAPFIRVVDRWVESIDAGESLVPSLREGVYSQLLMDLTHQSNEHRCWVDVPDLDTFLSLAETQRRRED
>NC_019689.1|WP_015145068.1|3808092_3808653_+|hypothetical-protein
MTAIDKNASQSHAAPLQKRIVSFLREHSEIETILAVALGLLVTRRFQLRGVKAVLINLLIINLIGQLLELLKQPDSGTSQRVREEKERTALQTVGSFGQYTILHAVPGRIRLRVPQLAQDRVFAQRLEELLADDENVVDVRINRDAASVAIKYQTREISDIELGWRLMNILNRAESEEQSVETAAH
>NC_019689.1|WP_015145069.1|3808746_3809004_-|DUF5132-domain-containing-protein
MFNRLKIFCQNNPGKAIAIGIGAVVLAPTLVPLLKPAAKASLKTGVLFYNKAKESLAETREILEDIVEEAKAEIAAEQMQKDEDD
>NC_019689.1|WP_015145070.1|3809192_3809612_+|ribbon-helix-helix-protein,-CopG-family
MNQNRDEATLEVNVPQAWIEQFETLANQSGRSASELVREALARYLDISGQQPATSLDRLSSELKTFKAELAELTQKVNALSEKSYLITTMSARLTTLERAISLGNLKQTTTSTPCQLMDTDDDDYDDEPDEILTDFLMG
>NC_019689.1|WP_051036454.1|3809915_3810365_+|hypothetical-protein
MEFPLNDLLNRDKCRQWILEHFHPDGLSCPNCKAGVEQARRFRTTHRSQLRVYRCRVCDHTYNLYSGTLLAQHHLRPERVVLLLRGILKGESTKSLAGELQLNYKTALTLPHQLQARAEQLQSQEPVPDTRTETDEMFQKAGEKRRAAS
>NC_019689.1|WP_071880594.1|3810438_3810846_+|transposase
MVGTVGRNSGQVRLRVVRNTTGEILVNHVHQFTVIESQLFTDESASYNHVIRPHATVCHSQHEWARDDEGDGLREVHVNTVEGMWTDMRNFLSSFKGVHQERLSGYVAIFEFKGNLKRICPAFIASLVTPHTSYL
>NC_019689.1|WP_144266215.1|3810957_3811458_-|hypothetical-protein
MAPILSLGLATIMAIPTLALSLEEKQLEREPSSDRASEVYFAEAASKKSPLADGIYLYGQSPEPEQIGQEYLVFRVQQGKVIGAVYLPRSEFNCFSGTVDSHRMNLSIVDPYNNAVYPYEIALQDLSPVASGDRLPRAVGLEGYHQISTISENDRRILDVCLQKYQ
>NC_019689.1|WP_015145072.1|3811911_3812898_-|RNA-polymerase-sigma-factor,-RpoD/SigA-family
MPTAKVNSNKQQPVFSADMVRTYLHEIGRVPLLTHEQEIVYGKQVQRMMTLLEKKEELASKLGHEPSLTEWANYVQLGEDELNRAIAQGNRAKRKMIEANLRLVVAIAKKYQKRNMEFLDLIQEGSLGLERGVEKFDPTKGYKFSTYAYWWIRQAITRAIAQQARTIRLPIHITEKLNKIKKTQRELAQQLGRSATPGEIAQALDLEPAQIREYLSMARQPVSLDVRVGDNQDTELSDLLEDEGISPDNYITQELLRQDLNNLMAELTPQQREVLSLRFGLEDGKELSLAKIGQRLNISRERVRQLEHQALAQLRRRRSNVREYIVAS
>NC_019689.1|WP_015145073.1|3812884_3813037_-|hypothetical-protein
MEETQSHTDFDLESLLLVLANKQNGFHQGIESTQTFCSFQGVITVQNAHC
>NC_019689.1|WP_015145074.1|3813502_3813682_+|ssl1498-family-light-harvesting-like-protein
MPYTEEDGGRLNNFAVEPRVYQASPPTKTEQRNYIILGVIAALLVGGLITVAVYASKVG
>NC_019689.1|WP_144266216.1|3813760_3814480_-|tetratricopeptide-repeat-protein
MSAVEWYNQGVDKIEAGDFQGAIADFTRAIELNPEDPDSYYNRAYAYHALGNYQPAIDDYGKAIELNPNYAYAYGNRCYAFYLMKRYDDAVSDCTKAIELEPKLADFYIYRGDAQDALDKHEEAIEDYTEAIRLKDDSANTYYKRALAYGALEEYQKALDDYTESIRLDESLADAFYQRGIVNSKLGNEEEAIADIEQAVKLFNEQNKPEESKKALKTLEDIRGTQERESNEDREDTEE

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Crispr_ID: NC_019689_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_13

3907420-3907540

Orphan

Consensus_repeat	Method
TGACTAATGACCAATCCCCAATCCAAAATCGATCTTACTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019689_13

>merge|NC_019689|13|3907420-3907540|CRISPRCasFinder
TGACTAATGACTAATGACCAATCCCCAATCCAAAATCGATCTTACTGCAGAAATTTACTCGAAGCGGATTTTTTACGATTTGACTAATGACCAATCCCCAATCCAAAATCGATCTTACTGC

>NC_019689|13|13|3907420-3907540|CRISPRCasFinder
TGACTAATGACTAATGACCAATCCCCAATCCAAAATCGATC	TTACTGCAGAAATTTACTCGAAGCGGATTTTTTACGATT
TGACTAATGACCAATCCCCAATCCAAAATCGATCTTACTGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015145155.1\|3903392_3903608_+\|4-oxalocrotonate-tautomerase-family-protein	unknown	unknown	gnl\|CDD\|224853
NC_019689.1\|WP_015145154.1\|3902199_3903351_+\|hydrogenase-formation-protein-HypD	unknown	unknown	gnl\|CDD\|237892
NC_019689.1\|WP_144266134.1\|3904588_3905053_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145169.1\|3921304_3921832_-\|Spy/CpxP-family-protein-refolding-chaperone	unknown	unknown	gnl\|CDD\|197366
NC_019689.1\|WP_015145166.1\|3918300_3918969_-\|YdcF-family-protein	unknown	unknown	gnl\|CDD\|99750
NC_019689.1\|WP_015145153.1\|3901424_3901991_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145152.1\|3900763_3901249_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145158.1\|3905256_3907002_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	unknown	unknown	gnl\|CDD\|236020
NC_019689.1\|WP_015145156.1\|3903608_3904403_+\|aminotransferase-class-IV	unknown	unknown	gnl\|CDD\|223193
NC_019689.1\|WP_015145148.1\|3897260_3897443_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145164.1\|3917424_3917748_-\|DUF2973-domain-containing-protein	unknown	unknown	gnl\|CDD\|371413
NC_019689.1\|WP_041393517.1\|3916711_3917371_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|283403
NC_019689.1\|WP_015145160.1\|3907888_3909118_-\|DUF445-domain-containing-protein	unknown	unknown	gnl\|CDD\|226834
NC_019689.1\|WP_015145161.1\|3909148_3909859_-\|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	unknown	unknown	gnl\|CDD\|234689
NC_019689.1\|WP_015145167.1\|3919811_3920831_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381327
NC_019689.1\|WP_015145151.1\|3900340_3900589_+\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	unknown	unknown	gnl\|CDD\|376549
NC_019689.1\|WP_015145168.1\|3920865_3921291_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239328
NC_019689.1\|WP_015145165.1\|3917865_3918225_-\|DUF2605-domain-containing-protein	unknown	unknown	gnl\|CDD\|371248
NC_019689.1\|WP_015145162.1\|3910459_3912073_-\|peptidase-domain-containing-ABC-transporter	unknown	unknown	gnl\|CDD\|225183
NC_019689.1\|WP_015145150.1\|3897725_3900281_+\|carbamoyltransferase-HypF	unknown	unknown	gnl\|CDD\|223146

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015145155.1\|3903392_3903608_+\|4-oxalocrotonate-tautomerase-family-protein	gnl\|CDD\|224853	COG1942, COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only].	1.90664e-20
NC_019689.1\|WP_015145154.1\|3902199_3903351_+\|hydrogenase-formation-protein-HypD	gnl\|CDD\|237892	PRK15062, PRK15062, hydrogenase isoenzymes formation protein HypD; Provisional.	0
NC_019689.1\|WP_015145169.1\|3921304_3921832_-\|Spy/CpxP-family-protein-refolding-chaperone	gnl\|CDD\|197366	cd09916, CpxP_like, CpxP component of the bacterial Cpx-two-component system and related proteins. This family summarizes bacterial proteins related to CpxP, a periplasmic protein that forms part of a two-component system which acts as a global modulator of cell-envelope stress in gram-negative bacteria. CpxP aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Functioning as a dimer, it inhibits activation of the kinase CpxA, but also plays a vital role in the quality control system of P pili. It has been suggested that CpxP directly interacts with CpxA via its concave polar surface. Another member of this family, Spy, is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy suggests similar functions. A characteristic 5-residue sequence motif LTXXQ is found repeated twice in many members of this family.	5.12727e-18
NC_019689.1\|WP_015145166.1\|3918300_3918969_-\|YdcF-family-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	1.25079e-20
NC_019689.1\|WP_015145167.1\|3919811_3920831_+\|aldo/keto-reductase	gnl\|CDD\|381327	cd19101, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	0
NC_019689.1\|WP_015145158.1\|3905256_3907002_+\|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase	gnl\|CDD\|236020	PRK07449, PRK07449, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Validated.	0
NC_019689.1\|WP_015145156.1\|3903608_3904403_+\|aminotransferase-class-IV	gnl\|CDD\|223193	COG0115, IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism].	7.22196e-49
NC_019689.1\|WP_015145164.1\|3917424_3917748_-\|DUF2973-domain-containing-protein	gnl\|CDD\|371413	pfam11189, DUF2973, Protein of unknown function (DUF2973). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently they have no known function.	1.34997e-35
NC_019689.1\|WP_015145162.1\|3910459_3912073_-\|peptidase-domain-containing-ABC-transporter	gnl\|CDD\|225183	COG2274, SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms].	0
NC_019689.1\|WP_015145160.1\|3907888_3909118_-\|DUF445-domain-containing-protein	gnl\|CDD\|226834	COG4399, COG4399, Uncharacterized protein conserved in bacteria [Function unknown].	1.37406e-132
NC_019689.1\|WP_015145161.1\|3909148_3909859_-\|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	gnl\|CDD\|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	9.3303e-127
NC_019689.1\|WP_015145151.1\|3900340_3900589_+\|HypC/HybG/HupF-family-hydrogenase-formation-chaperone	gnl\|CDD\|376549	pfam01455, HupF_HypC, HupF/HypC family.	1.67336e-27
NC_019689.1\|WP_015145168.1\|3920865_3921291_+\|hypothetical-protein	gnl\|CDD\|239328	cd03030, GRX_SH3BGR, Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. The SH3BGR gene was cloned in an effort to identify genes mapping to chromosome 21, which could be involved in the pathogenesis of congenital heart disease affecting Down syndrome newborns. Several human SH3BGR-like (SH3BGRL) genes have been identified since, mapping to different locations in the chromosome. Of these, SH3BGRL3 was identified as a tumor necrosis factor (TNF) alpha inhibitory protein and was also named TIP-B1. Upregulation of expression of SH3BGRL3 is associated with differentiation. It has been suggested that it functions as a regulator of differentiation-related signal transduction pathways.	0.00261908
NC_019689.1\|WP_015145165.1\|3917865_3918225_-\|DUF2605-domain-containing-protein	gnl\|CDD\|371248	pfam10792, DUF2605, Protein of unknown function (DUF2605). This family is conserved in Cyanobacteria. The function is not known.	5.64594e-60
NC_019689.1\|WP_041393517.1\|3916711_3917371_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|283403	pfam05728, UPF0227, Uncharacterized protein family (UPF0227). Despite being classed as uncharacterized proteins, the members of this family are almost certainly enzymes that are distantly related to the pfam00561.	6.78751e-45
NC_019689.1\|WP_015145150.1\|3897725_3900281_+\|carbamoyltransferase-HypF	gnl\|CDD\|223146	COG0068, HypF, Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones].	0

>NC_019689.1|WP_015145158.1|3905256_3907002_+|2-succinyl-5-enolpyruvyl-6-hydroxy-3--cyclohexene-1-carboxylic-acid-synthase
MPLDFRNVNALWSSIVVETLSRLGLTVAVICPGSRSSPLTIAFARHPAIEAIPILDERSAAFFALGIAKRKGLPVALICTSGTAGANFYPAVIEAKESRVSLIIMTADRPPELRHCHAGQTIDQVKLYGNYPNWQTELAVPSLDMGMLCYLRQTLIHAWERSRFPIPGVVHLNFPFREPLAPIPNPDTEALASEFDSEEFFARIVSSENYIHPLSRIPLPLDNWQSCERGIIIAGVMSSHHNKEYCQAIARLSCFLNYPVLAEALSPLRNYADLNPYLIATYDPILRDRQLAEKLAPEIVIQLGELPTSKELRTWLETTQPHRWIVDPSWENFDPLHGKTIHLRTSIEQLTHHLPEPAIANPTNYLKYWCEAETQVRQTIDRTMRAIDHFLEGKAAWLLSQTLPPDTPIFIANSMSVRDLEFFWMPRNSGIIPYFNRGANGIDGTLSTALGIAHRHQSSVLLTGDLALLHDTNGFLIKQKFIGHLTIILINNNGGGIFEMLPISQFEPPFEEFFATPQNINFAKLCATYEVEYQLITTWKQLEQLLNPLPEIGVRVLEVQTDRKADARWLQDNLKKFAGDR
>NC_019689.1|WP_144266134.1|3904588_3905053_+|hypothetical-protein
MLALKRGKRDIGVSLMLLHIGLIIGIGITLVVGSFSASAEPLNEPKPLPPVDASSSSSLDTIEVGNRNRESFFPANPQGTVTNYSESRNENEFDPLGKGFILDFGDNLRSKRELDASMAPGDDGDNTKVRLLIDMTELDNSTDEGAGERGRQGN
>NC_019689.1|WP_015145156.1|3903608_3904403_+|aminotransferase-class-IV
MFWYDGELIEGDSLSIGIDDPGLLYGATVFTTLRVYDRSLDRPLTHWQLHCDRLRHSIQAFEWQSPDWRRLRQGVEILLAYYPVLRIAIFADGREWIIGQSLPVDLKERQQQGIVGWVADESLYRRSLAAYKTGNYLSAWLARQKAQKLGAKEAILLDEAGNWLETSTGNLWGWKEECWWTPALEEKLLPGIARSQLIEWLQSQNIPVKQNRWTPEFVRDLEAIAYSNSVMEIIPFSLIIHPLGKQFLNCNLLALEHLRSYFLT
>NC_019689.1|WP_015145155.1|3903392_3903608_+|4-oxalocrotonate-tautomerase-family-protein
MPFVTIQIAKGHSVELKRKLAQAVTDTLVSTLGTKPEWVTIHIDEFDPENWAVGGELHIDRHSDKHAQKKS
>NC_019689.1|WP_015145154.1|3902199_3903351_+|hydrogenase-formation-protein-HypD
MKYVTEFRDPQKAKALLEEIKRLSELLEKTPEEPLKLMEICGGHTHSIFKYGIEEALPASIELIHGPGCPVCVMPRGRLDAAIALAEHPNVIFTTFGDAMRVPGSKKSLLQAKAEGADIRTIYSPLDALPIAKDNPDKEVVFFGIGFETTAPSTALTVLQAEAEGIHNFSLFCNHVLVVPALEALLVNPDLKLDGFIGPGHVSTIIGIEPYQIIAEKYHKPLVISGFEPLDILQSIWMLLKQIIEGRCEVENQYTRLVKEGGNSIALETMGKVFEVRDKFEWRGLGEITESGLKIKEEYAYFDAEVKFCVPNLKVADSAACQCGEILKGVLKPWECKVFGTACTPETPIGTCMVSSEGACAAYYKYGRLSTLAKAAKPNKVSA
>NC_019689.1|WP_015145153.1|3901424_3901991_+|hypothetical-protein
MTDILKEILNILKENENIRSIISALLLIFVFRLKDIYEFVDCLLNRKVTRLENLLKGDLDRETREAVQEELYSKYFQQTTGIKAEKHLREKITKLVESANGRITYSDINHVFKHDFLFCDHNGELRIRKINRQDRISYRFWRIISLSFWVLGLLLILLTILFKIDDPSKIKIGILLTFSQAEIRMSSV
>NC_019689.1|WP_015145152.1|3900763_3901249_+|hypothetical-protein
MQTTEQQFSWYDIPEDIKNLLVLASENWENTAESQKYVNEALAKAEDNLDVLVGAYRFFFYKNNSEMAIKIAEKVSKKLKQENNLPDEWEKLQPILAERKNESPIRMYLNAYAAQGFLLARLGKIEEAKEITERVKEIDEKRESCATTVFEVLTQPPEEDE
>NC_019689.1|WP_015145151.1|3900340_3900589_+|HypC/HybG/HupF-family-hydrogenase-formation-chaperone
MCLGIPGQIVEITDATHKLALVDIGGVKRQVNIACIVDDEHPIESYIGDWVQVHVGFALSRLDEQEAAETLEMLAEMAAAIE
>NC_019689.1|WP_015145150.1|3897725_3900281_+|carbamoyltransferase-HypF
MVRLRSTNAEIAEEIRVRGTVQGVGFRPTVYRLAKDCRLRGEVGNDGEGVWIYVAGKRDAIDTFVERLRVECPPLAKIEAIIRRPYEGDRTFTDFTIAESSSTSIRTEIAADAATCPACRAEIFDPFSRWYRYPFTNCTHCGPRLSIIKRLPYDRSNTSMAEFKMCPDCIRNYEDPSDRRFHAQPTACPVCGPKAWLERFDGKPITAHMFSMLDDVDVVCTLIQQGQIVAIKGLGGFHLACDATNEAVVQKLRYSKRRPDKPLALMARDINIIEKYCLVSAAERELLESPAAPIVLLQRRERDNQSDESKIQNLIAPSVAPGQNYLGFMLPYTPLHHLALKRLEIPIVLTSGNLSDEPQCIDNEDARKKLAGIADYFLFHNRDIVNRVDDSVVCIIGIRNSKTLNFLPKPLTRQEINFLANKQNSLKRTCAVSLGIDSQSEVGIQARNRFQILRRARGYAPAPINLPEGFKDIPPILAMGSQLKNTFCLLRDGQAILSQHIGDLENAAASEAYKKTLDLYLSLLEHQPKAIAIDLHPEYLSTKLGKELAAANSLKLYAIQHHHAHVAACMAENHLPIDAPPVLGIALDGLGYGEDGTLWGGEFLLADYQGYKRLGTFKPVAMLGGEQAIYQPWRNTYAHLKAAFGAELPPENLELLTFLKQKPLTLLDQMMEKGINSPLASSGGRLFDAVAAAIGICRESCSYEGQGAIALEAIAESCILTHSEEIEGYPFTIANLEGRGRSPLPYLEPRPMWQALLEDLKQDTPQEVMAAKFHQGLANAIASMVDRIRYGEEKINRVALTGGVFQNRLLLVELCDRLQAMGIQVLTHGKVPSNDGGLSLGQVAIAAARFF
>NC_019689.1|WP_015145148.1|3897260_3897443_+|hypothetical-protein
MEAQTNEIKQIAAQLLAGMLANPHIYARVSDEGSNGQQEQALMLMAIEMAESLIKRIEKQ
>NC_019689.1|WP_015145160.1|3907888_3909118_-|DUF445-domain-containing-protein
MDSATLWTLIVPPLGGAIIGYFTNDIAIKMLFRPYRAIYIGKRRLPFTPGLIPANQERLAKRISDTIMGSLLTPDELQKLAKRLLATERVEGAIRWLLNLGLKQVRGDRQQKTAKILAEILRDLFGESLPRLLKALSRREDFLEEQINQIFDKVLLEFSLSDLQARQLADWLLETVVPPDIIRQALIDFLTDRNIQVIDESFREKTSGTYWVVANLFGLRNALARLRTFCLDEKEIANTRLKELLLSLEARNRLRTWLQSLSLQHLPISTVRQLRKTIRDIVRTYIQESGAEFLQEFGKSVDWEQIASLIVNRLQSSQAVTSSLETIGRELALILERYLEEDLEKLVEQIIPILSIDQVIIARVQATSPQELELAIQGIVKNELQAIVNLGGILGFIVGLTQTILLLLR
>NC_019689.1|WP_015145161.1|3909148_3909859_-|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE
MTNNMSPAASEIQAIFDRIAPVYDQLNNWLSLGQHRIWKLMAVKWSEPSPGYVGLDLCCGSGDLAQLLARQVGSTGRVVGVDFSKEQLAIARQRNSNQFSPFPIEWVEGDALSLPFDDNTFDCATMGYGLRNVTDIPRCLQELYRVLKPGAKAAILDFHRPDQSLMLAFQQWYLQTIVVPTARRFGLTEEYAYISPSLERFPTGIEQIKLAYEAGFARAIHYPIAGGMMGVLVITK
>NC_019689.1|WP_015145162.1|3910459_3912073_-|peptidase-domain-containing-ABC-transporter
MASPFLLQILTDDVLVRQDTNLLAIAIVGVVIMQLFSGSLLLLQSNPIAHFSQRLQLGLVLEFGRQILRLPLNYYEARRSGEIVSRLRDINDINQLISQVVVSLPSQFFVAVISFCLMLFYNGKLTLAAIAIGTIMTLSSLPFLPPLRRKNKNLMVLSAENQGVLVETFRGALVLKTTNAASQFWDEFQMRFGRLANLTFGTIQIDIINMTFSQLMSGIGGVALLGLGSMLVINKELTIGQLLAFNAMQARVLAFIGALISLTDEYFRSQIAVARLLETIDATPEDLGDPKKPLVLISGDDSISCQNLCFHHVGRVALLENFSLSLPGGVAIAIIGKSGCGKSTLAKLLAGLYQPQSGTIRIGSYNLNDLSLECLRDQVVYVPQEPHFWSRSILENFRLGNPNISFDRIVKACQIADADSFISQLPNAYQTVLGEFGVNLSGGQRQRLAIARAIVNDPPIPILDKSTAELDPISESEVLDRLLKHRQGKTTIMISHRPTTINRAEWLVLLDKGRLIVAGDLESLRTVPGEHLKFLSL
>NC_019689.1|WP_041393517.1|3916711_3917371_-|alpha/beta-fold-hydrolase
MLVSVSSYIYLHGFASSPYSTKAQYLRDRFWEHQISLKIPDLNQGDFSHLTLTRQLEQVASEFPDSEKTETPVTLIGSSFGGLTASHLAENYSQVRCLVLLAPAFGFIERWLSQLEEAQIRQWQESGYLSVYHYGEQRSLPLHYQFLIDASQYSERRLQRPVPTLILHGRNDEVIPIQSSRDYASQRPWVELVELKSDHALTDVLPEIWQAIQKFCQLQ
>NC_019689.1|WP_015145164.1|3917424_3917748_-|DUF2973-domain-containing-protein
MLHLMYILAFTVIAFLAISNLIRSLVTVSMDSQRRYSAAGKSSSGTKEVNWNRTGTTVHPELLDESGQPIDEPLLVMRSVTVEDARQQLDALYKASPGQTQETEEDA
>NC_019689.1|WP_015145165.1|3917865_3918225_-|DUF2605-domain-containing-protein
MSNSHPTEHELLKTILEPLLEDFQYWFSRAHTLLESEQISFLSPEEQAHLLKRVKTAQQEVNAAKMLFKATGEQAGIDTATLVPWHQLVAQCWQVAMRWRSLKGKLSQDSDSSDPNFAP
>NC_019689.1|WP_015145166.1|3918300_3918969_-|YdcF-family-protein
MPGKISSIRREVSVSQPRKTKKRFSLLLLPIIGASLWLGYKQGQSYLVKPEAAIVLGGHEDRERFAAKLAAQDPNILIWVSSGSPQKYVEKIFAEAGIDRDRLHLDYHAVDTVTNFTTLVDDLKSHGIDSVYLITSENHMRRALIIGEIVFGSRGIVIKPVSVPSDAPSEPIEKTLRDGARALLWLATGGTGETLIERKSRNIQSIKHSGRFPEDFVDRDKS
>NC_019689.1|WP_015145167.1|3919811_3920831_+|aldo/keto-reductase
MPLPTTSRLQFTPDLNICRVLNGMWQVSGAHGRINPNQAIQEMFQYMDAGFTTWDLADHYGPAEDFIGAFRRQLAASRGQEALANLQAFTKWVPRPAKMTRQLVEKNIDISLQRMGVEALDLMQFHWWDYRDTNYLDALHYMAELQKEGKIKHLALTNFDTERLKIIVDAGIKIVSNQVQFSLVDRRPLVKMVEFCQRNNLQLLAYGTLAGGLLSEKYLGQSEPELMSLTTASLRKYKNMVDVWGGWQLLQELLTVLKQIADKHRVSIANVAARYVLEQPTVAGAIVGARLSVSEHLEDNAKVFNFSLDEEDYRQLETVFSQSRDLYRLIGDCGDEYRR
>NC_019689.1|WP_015145168.1|3920865_3921291_+|hypothetical-protein
MINFGNNPSIDEANRWRSALDEFVAENEQALAALAWGLLQEWGDSQDALGIDLKPTPHFVRCSRAAIERLNRQVNRKIQEILGVLDGYDPEAEVVAIAIGEGQLKLIYFQPEPSPPVCFEQIEGDLDTLIQQLEERMRDKF
>NC_019689.1|WP_015145169.1|3921304_3921832_-|Spy/CpxP-family-protein-refolding-chaperone
MLLRRKSITVAIAIFLLAALAAIANPNLHSKPLASSSWQLPIAQMSRQVPVKDESKGRLLEQLNLTNDQKQQIASIRQKYRGQIEPLQDNAQAAQEELFNMMVGTELEKAIRTKRQEVVQLRQKLGDLRFESMMEMREVLTPEQRTQLLQMLQARRDDWRNRFGDGDRLNKNNWF

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Crispr_ID: NC_019689_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019689_14

4086008-4086092

Orphan

Consensus_repeat	Method
CGACTTTAGTCGATCGTCTTTGCAATCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019689_14

>merge|NC_019689|14|4086008-4086092|CRISPRCasFinder
CGACTTTAGTCGATCGTCTTTGCAATCTAGTAAGACTGGTATATTTGTCTATTTGTGCGACTTTAGTCGATCGCCTTTGCAATCT

>NC_019689|14|14|4086008-4086092|CRISPRCasFinder
CGACTTTAGTCGATCGTCTTTGCAATCT	AGTAAGACTGGTATATTTGTCTATTTGTG
CGACTTTAGTCGATCGCCTTTGCAATCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019689.1\|WP_015145305.1\|4092638_4093481_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
NC_019689.1\|WP_144266143.1\|4094883_4095078_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|187542
NC_019689.1\|WP_015145306.1\|4093747_4094671_+\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NC_019689.1\|WP_015145301.1\|4087645_4089919_+\|nitrate-reductase	unknown	unknown	gnl\|CDD\|239155
NC_019689.1\|WP_015145295.1\|4080435_4081479_+\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NC_019689.1\|WP_015145292.1\|4078898_4079780_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145289.1\|4074865_4076779_-\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145300.1\|4087064_4087388_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|171099
NC_019689.1\|WP_015145290.1\|4076781_4077489_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369778
NC_019689.1\|WP_015145296.1\|4082276_4083431_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226645
NC_019689.1\|WP_015145294.1\|4080143_4080266_-\|photosystem-II-reaction-center-X-protein	unknown	unknown	gnl\|CDD\|368995
NC_019689.1\|WP_015145302.1\|4089963_4090416_+\|nitrate-reductase-associated-protein	unknown	unknown	gnl\|CDD\|378232
NC_019689.1\|WP_015145303.1\|4090728_4091892_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NC_019689.1\|WP_015145299.1\|4086102_4086780_+\|5'/3'-nucleotidase-SurE	unknown	unknown	gnl\|CDD\|234732
NC_019689.1\|WP_186005400.1\|4086844_4087057_-\|Txe/YoeB-family-addiction-module-toxin	unknown	unknown	gnl\|CDD\|284238
NC_019689.1\|WP_015145291.1\|4077485_4078619_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133030
NC_019689.1\|WP_015145293.1\|4079817_4080042_-\|CPXCG-motif-containing-cysteine-rich-protein	unknown	unknown	gnl\|CDD\|379524
NC_019689.1\|WP_015145297.1\|4083476_4084259_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223488
NC_019689.1\|WP_144266142.1\|4074328_4074745_+\|hypothetical-protein	unknown	unknown	unknown
NC_019689.1\|WP_015145304.1\|4091970_4092624_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251

Protein	Function_ID	Function_description	E-value
NC_019689.1\|WP_015145305.1\|4092638_4093481_-\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	9.89222e-134
NC_019689.1\|WP_015145306.1\|4093747_4094671_+\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	1.47876e-79
NC_019689.1\|WP_015145301.1\|4087645_4089919_+\|nitrate-reductase	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NC_019689.1\|WP_015145295.1\|4080435_4081479_+\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	2.46909e-176
NC_019689.1\|WP_015145290.1\|4076781_4077489_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369778	pfam08242, Methyltransf_12, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	3.70365e-08
NC_019689.1\|WP_144266143.1\|4094883_4095078_-\|hypothetical-protein	gnl\|CDD\|187542	cd05231, NmrA_TMR_like_1_SDR_a, NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs. Atypical SDRs related to NMRa, TMR, and HSCARG (an NADPH sensor). This subgroup resembles the SDRs and has a partially conserved characteristic [ST]GXXGXXG NAD-binding motif, but lacks the conserved active site residues. NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. HSCARG has been identified as a putative NADP-sensing molecule, and redistributes and restructures in response to NADPH/NADP ratios. Like NmrA, it lacks most of the active site residues of the SDR family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Atypical SDRs are distinct from classical SDRs. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.5951e-06
NC_019689.1\|WP_015145299.1\|4086102_4086780_+\|5'/3'-nucleotidase-SurE	gnl\|CDD\|234732	PRK00346, surE, 5'(3')-nucleotidase/polyphosphatase; Provisional.	5.93039e-93
NC_019689.1\|WP_015145296.1\|4082276_4083431_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|226645	COG4177, LivM, ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism].	2.57542e-46
NC_019689.1\|WP_015145294.1\|4080143_4080266_-\|photosystem-II-reaction-center-X-protein	gnl\|CDD\|368995	pfam06596, PsbX, Photosystem II reaction centre X protein (PsbX). This family consists of several photosystem II reaction centre X protein (PsbX) sequences from both prokaryotes and eukaryotes.	1.51228e-16
NC_019689.1\|WP_015145302.1\|4089963_4090416_+\|nitrate-reductase-associated-protein	gnl\|CDD\|378232	pfam09655, Nitr_red_assoc, Conserved nitrate reductase-associated protein (Nitr_red_assoc). Proteins in this entry are found in the Cyanobacteria, and are mostly encoded near nitrate reductase and molybdopterin biosynthesis genes. Molybdopterin guanine dinucleotide is a cofactor for nitrate reductase. These proteins are sometimes annotated as nitrate reductase-associated proteins, though their function is unknown.	8.82987e-95
NC_019689.1\|WP_015145303.1\|4090728_4091892_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NC_019689.1\|WP_015145300.1\|4087064_4087388_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|171099	PRK11409, PRK11409, YoeB-YefM toxin-antitoxin system antitoxin YefM.	3.5531e-13
NC_019689.1\|WP_186005400.1\|4086844_4087057_-\|Txe/YoeB-family-addiction-module-toxin	gnl\|CDD\|284238	pfam06769, YoeB_toxin, YoeB-like toxin of bacterial type II toxin-antitoxin system. YoeB_toxin is a family of bacterial toxins that forms one component of the type II toxin-antitoxin system in E. coli whose antitoxin is represented by YefM, found in pfam02604. The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair. When the plasmid is lost, the antitoxin is degraded relatively quickly by host enzymes. This allows the toxin to interact with its intracellular target, thus killing the cell or impeding cell growth. These toxins are highly potent protein synthesis inhibitors, specifically blocking the initiation of translation. In the case of YoeB, it binds to the 50 S ribosomal subunit in 70 S ribosomes and interacts with the A site leading to mRNA cleavage at this site. As a result, the 3'-end portion of the mRNA is released from ribosomes, and translation initiation is effectively inhibited.	1.20942e-16
NC_019689.1\|WP_015145291.1\|4077485_4078619_-\|glycosyltransferase	gnl\|CDD\|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	4.5545e-19
NC_019689.1\|WP_015145293.1\|4079817_4080042_-\|CPXCG-motif-containing-cysteine-rich-protein	gnl\|CDD\|379524	pfam14255, Cys_rich_CPXG, Cysteine-rich CPXCG. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There are 5 conserved cysteines which occur in a CPXCG motif and a DCXXCCXP motif.	3.33979e-21
NC_019689.1\|WP_015145297.1\|4083476_4084259_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223488	COG0411, LivG, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	1.95805e-122
NC_019689.1\|WP_015145304.1\|4091970_4092624_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	5.67951e-53

>NC_019689.1|WP_015145297.1|4083476_4084259_+|ABC-transporter-ATP-binding-protein
MANEEQPTTNNILSATGLSKSFGGLRAVNEAKICVKKGTITGLIGPNGAGKTTLFNLLSNFIRPDKGEVIFDGEPIHHLQPYQIALQGCVRTFQVARVLSRLTVLENMLLATQKQTGENFIQLWFQRGQVRQEERENKERAMEILESVGLAAKAQDYAGALSGGQRKLLEMARALMTRPKLILLDEPAAGVNPTLIGQICEHIMNWNKQGISFLIIEHNMDVIMSLCNHVWVLAEGTNLADGTPEEIQTNPEVLEAYLGE
>NC_019689.1|WP_015145296.1|4082276_4083431_+|branched-chain-amino-acid-ABC-transporter-permease
MNGDILSQLTASSGYIVFLVTSAGLYSLFALGLNLQWGLTGLINFGHVAFMTVGAYTTALLTLQGVPLIIAAIAGAGLAALLGLAIGTSTLRLREDYLAIVTIGVSELLRLVVLNEEWLTRGSFGVQRYPLPLNVRFNPIGELLLIGILTLLAIFAGWQLWQGLRRQWNESQLIKDKRPTKRVSLIIWGIIATALILVIYVNGVIALSNYTYKAGLMLLVLLVLALVYNALEFLARSPWGRILKAIREDEEIPRALGKNVFWYKLQAFMLGGAIAGIAGAFFAWQLTTIYPTNFEPLLTFNAWIIVVLGGAGSNAGTLLGAVIFWAYDTLTRFLLPQIGIQIGITNEAQLGGLRIMIIGLILMMLMIWRPQGILGKKEELTLGR
>NC_019689.1|WP_015145295.1|4080435_4081479_+|anthranilate-phosphoribosyltransferase
MTQTTTIDWSNLLQQLLDRQSLSQTQAAQLMQGWLKEEIPPVLSGAILAAIQAKGVSADELTGMAQVLQAQSLQQAPIQHAQPVIDTCGTGGDGASTFNISTAVAFVAAAAGVKVAKHGNRSASSKVGSADVLEYLGVNLSAPSEKVEAALSEVGITFLYAPGWHPAMKSVAPLRRTLKVRTAFNLLGPLVNPLRPTGQVIGVYDAQFLEPMAHALKQLGTPKAIILHGREKLDEAGLSDVTDLALLSDRKVELSQLQPEVLGLTPAPIEALRGGNVQDNAEILRNVLQGGGTQAQQDAVALNASLALQVGEVVFFEDRRQGVEKAKEILRSGAAWSKLEELVRFLR
>NC_019689.1|WP_015145294.1|4080143_4080266_-|photosystem-II-reaction-center-X-protein
MTPSLANFLWSLVWGAVIVVIPVTVGLIFISQKDKIDRKV
>NC_019689.1|WP_015145293.1|4079817_4080042_-|CPXCG-motif-containing-cysteine-rich-protein
MSLLNRSENFYKRQTTTEYFCAFCGESNSTFVDLSAGMQQSYVEDCQVCCRPNVLYVQVDEETLDVEIYTDYEE
>NC_019689.1|WP_015145292.1|4078898_4079780_+|hypothetical-protein
MPKQVSQIGFIGATVVGLTCLMTPANSATIQTSTQKALVVGENNRVTQLSQQTSLDLFFFDLHLDRKSFLDESPIKNFINSEILEFINDFGENILEIDQSISQIARLSGNNNRVTQISAQNIFDVFFLDPELRVTMGENTTYTLPVFDISQILSDRVAAQLPDIEQSVIQEANVFGSDNQVRQVNAQTVIDFFLIDIKFSAQLVDIVVRRTDDNLDNLVNFELYNFLDDLETLLPFQELPDSFFQDNNPIVLENRNYSINEVQSITVPESSSVFALLSLTAIGLGSAILRKYK
>NC_019689.1|WP_015145291.1|4077485_4078619_-|glycosyltransferase
MKKQQISLRQQITPQDWEKTPASVKMLVEEIVGNLKLLDSQLDELSTQERSHQAEFHQKRKLVVVIPSFNDWQPLEKLLLLIDEIILAQAIEIEILIVDDYSTQPIPESLICQQYRQIRKVNVLRLRRNLGHQRAIAIGLSYLYHNINCDLVVVMDGDGEDSPLAINRLLSVSDDTGNNKIIFARRSQRSEGNTFKFFYWIYKTVYRLLIGREINVGNFSLLPASLLKNIVAISEIWNHYSSGIYRSRLPYLEVNIPRARRLAGKPKMNLVSLVTHGLSSIAVYGDVVGTRILLSIIVLLILFLIVLCLVFLVKFLTKWAIPGWATYVSGLLVVSLLQLVILGTVFSMIILSTRNNLGFIPMRDYKYYVEECFQLKP
>NC_019689.1|WP_015145290.1|4076781_4077489_-|class-I-SAM-dependent-methyltransferase
MSQFIYVGTELELFAQAKNWKDYLRVLLRRYIKGDVLEVGAGIGSNTRLLCRSQYQKWLCLEPDTQLFQDLENSIRSNNIIDCFASNGKIDSLHEEQLFDAILYLDVLEHIKRDREEVIKASRHLKPDGNLIIVAPAHQWLFTPFDTAIGHYRRYNKQTLKAVLPDDIEIIKLNYLDCVGLLASLGNKLVLKQSQPTLKQIKVWDRFMVPISRKLDPIIGYSFGKSVLLVGRKKF
>NC_019689.1|WP_015145289.1|4074865_4076779_-|hypothetical-protein
MKVVRNQKFASKCISIIILFILISFAFSSIVIQDFSYPLTGWVGIGSFGWLNYDYVDLQEYTGYYLAKNLSFAPFPQLDLFNNQSFYPYGTNSVFQPWSLEKDYFYAILYSFFGTGPWLQIYYLLTVLINAIGTFALLLRDYGFARSAGIGFIVSFGNFYAINKYPHHLQYAVIHWIVLSLIADFLIVKRIVFKQHLSLRLILVRACLLFLSFGHDLGYMAGFSLMSFTVSLLFIAVLITNRYLKRELKLIQGIQRALKTYKNDFRSYPRTCLVLLSLTLLTAYFYFSLAFQIGKEAKSFDFTDISFDTFWANPLRLLVPFFPFINPGMDYQQFFSDVPESVGDSSPGWFLVILGTLGLWQARRQITIFIPLLIVFLLCLFYHPLLFPTLKIFPWYAFNRVGGRSTFIYPVILSIFALHINFDWLHFRQRQLLAGFLILVASIELYTAYSYRLDYKPASLDQSFFTYMEYIKKQPGEAVLDLFFCIAGSGARPGICPYYGYNSGVFALRRFHEKKVMGQYFGRLYPSQVKPYLEAGWDKLFFPDNTQSRQSRCFNEAEWSFLTDFFKFNDFAGINLYIERFPEKCLNEFYDRLGNPAKETVIPGAGKVQFIPKSSELRKQVNLSLGTKVKLETSTEL
>NC_019689.1|WP_144266142.1|4074328_4074745_+|hypothetical-protein
MNRLLFFSSMFLLSFGSNLPAIAQEITSIASVDQTVLIARADRVYLTEDEDGNPCLEDKYGNRVSLREDKDGTYFKDEDGNRVYLEEDDDGDTYFEDEDGDRVYVEEDKDFGRSSIDRDRNIEVEENEDGRDIYIETR
>NC_019689.1|WP_015145299.1|4086102_4086780_+|5'/3'-nucleotidase-SurE
MTLILTNDDGIDAPGIRALQKALNGRGIIVAPKDHLSGCGHKVTTTRPIHLQKRSDSEYAVDGTPADCTRLAITHIAPETKWVLSGINAGGNLGIDTYISGTVAAVREAAIHGIPGIAISHWIRRPLIVDWDLASVWTAKVLAELFNRPIPPKSFWNVNLPHIEPNSPEPEIVFCEPSTQPLPLKYRIEGDLFYYEGEYSKRDRATGTDVDVCFSGKIAVTLIQL
>NC_019689.1|WP_186005400.1|4086844_4087057_-|Txe/YoeB-family-addiction-module-toxin
MQQVSRFPVFSERFREDLGWWYKTDKQKAYKILDLVEAVMKDPFKGVGKPEPIKYLDTDTWSRRKENFTI
>NC_019689.1|WP_015145300.1|4087064_4087388_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MFALQTSYTQARENLATLLDQIENENTIAVIKRRGHKDIALLAADELSSLLETVYLLRSPANARRLLDTLEESKKWDATESPLPHTIDELCSELDIERKKEKAELAI
>NC_019689.1|WP_015145301.1|4087645_4089919_+|nitrate-reductase
MTDSVKTLCPYCGVGCGLEVSPPAAAGRATHRDSQGNPIWKVVGDRSHPSSQGMVCVKGATISESLDKDRLKYPMMRDSLSDPFRRVSWDEALDRIVARIRTVIATQGSDGICLYGSGQFQTEDYYVAQKLIKGCLGTNNFDANSRLCMSSAAAGYIQSFGSDGSPCCYDDLELTDCAFLIGTNTAECHPIVFNRLHKHIKRDRKAKLIVVDPRRTKTAEAADLHLAINPGTDIDLLNGIAHLLMRWDKIDTLFIDECTKDFPAYAEVINHYSPELVARKCGIRIDHLEQAARYWAESERVLSLWSMGVNQSSEGTAKVRTIINLHLMTANIGKPGAGPFSLTGQPNAMGGREAGGLAHILPGYRSVTNSQHRAEVERLWQLPAGRISPNPGRDAWSMITGLETGEVGLLWIAATNPAVSMPDLERTKAALLKSPLTVYQDAYYPTETAAYAHILLPAAQWGEKTGTMTNSERVVTLCPQFRLRPGEAKADWEIFAEVGRRLGFVEQFNFPDSAAVHREFVQATRNRPCDMTGISYDRLQQEGPIQWPCPLDGGGENTSTQQSGILSHLFKGKEEKPKGKRLYTNWRFNTPDGRARFAAYHSKGLAEPTDEAYPFVLTTGRLYGHWHTQTRTGRIEKITKMHPNPFVEINPRDAEKLGIKDGDWIEVRSRRGKARFPAKVTKAIAPGTVFVPMHWGALWAENAEANSLTHPKACPDSLEPELKACAVQLVPIAAISEAGTEKPVQISSVPEYVSSPS
>NC_019689.1|WP_015145302.1|4089963_4090416_+|nitrate-reductase-associated-protein
MTDFFQFEADFVDSLRCIPMQVRMKLDTCGVKLKLFHWNQFSQEERQTLVALPCTTVEESQVYRDYLQNLVKEKTGKPAGELAIEPHPPWLDASTVPAQTQEKAAEFGIAITAQQWENLTPAQRFALIKLSRPGHENQNFFPALKEFKLA
>NC_019689.1|WP_015145303.1|4090728_4091892_+|pyridoxal-phosphate-dependent-aminotransferase
MKLSSRVGQVTPSLTLAIDSKAKAMKAEGIDVCSFSAGEPDFDTPQHVKEAAKLGLDQGKTKYGPASGEPKLRAAIAKKLYEDNHLNYQAENIIVTNGGKHSLFNLMLALIEPGDEVIIPAPYWLSYPEMVKIASGTPVIVDTPEENQYKITPDQLRQAITPRTKLFVLNSPSNPTGIVYTPDEIRALAEVIVERDILVVSDEIYEKILYDGAEHLSIGAVSEEAFKRTIISNGFAKAYSMTGWRVGYLAGPLELIKATITIQSHSTSNVCTFAQYGAIAALEGSQDCVQQMLAAFAKRRQYMLERISAIPNLSCPKPNGAFYVFIDISQTGMASIDFCKALLEEHQVAAVPGIAFGADRCIRLSYATDMTTIEKGLDRLDKFVRSL
>NC_019689.1|WP_015145304.1|4091970_4092624_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MTNDNQPREREPFTNLVLYHLFKWSVVSPMLHVYFRVRIYGTENVPQKGALVAVCNHGSYFDPPIVSNCLRRPVAYMAKEELFKIPVFKQAIELYGAYPVKRATSDRDAIQAALTALEGGWIAGIFLTGTRTPDGRITNPRRGAALIAAKAQVPLLPVSLWGTEKILRKGSPFPYPVPVTVRIGELIASPSSTKREELQQVTEKCAAVINAMHDLGR
>NC_019689.1|WP_015145305.1|4092638_4093481_-|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MSKDLKPGTLYLVGTPIGNLEDITFRAIGILQAVDLIAAEDTRHTGKLLQHFQIAAPQISYYEHNKRSRQEELLARLQKGETIALVTDAGMPGISDPGYELVKACIDAGISVIPIPGVTAAVTALAASGLPTDRFVFEGFLPIKGKERRDRLNFLKHETRTLILYEAPHRLLETLSDLASVLGENRQIVLARELTKVHEEFWRGTIRDAIALYTTNREPKGEFTLVVAGTQTQENLILSEEELKTELRRLIEQGMTRSQASRQLAQLTNIPRRQIYDLEI
>NC_019689.1|WP_015145306.1|4093747_4094671_+|cation-transporter
MVRDNRSEVRKVLILTLLLNLFVMGLKAVVGFQANSLSLQADALHSVTDSANNILGLIASRLSSPIPDRDHPYGHQKYEALGALGIAAFLGIACFEILKSATERILEGGSPVRIAGAELSLLIVVLGVNIFVAFYERKIGRKVGSPILIADAYHTMSDIWVTITVMAGLVGVWQGRVLNLPQLQWLDVILSFPVALLVFYSGWTVLKANVPWLVDEMAIAPEAIHQIVMEVPGVINCHDIASRGLLGRQIFIEMHLVVEATDVENAHKITEEVEIRLAEQFSPVRVIIHVEPPDYQHDRITFESEDS
>NC_019689.1|WP_144266143.1|4094883_4095078_-|hypothetical-protein
MLDVAQAFAKALQKPVKGMETPRDQWIGTMQNMGFSNKTAVFFSKITTLAIKRKCQSAIALHEE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	MN693129	Marine virus AFVG_25M62, complete genome	42085-42114	6	0.8
NC_019689_3	3.20\|1228101\|36\|NC_019689\|PILER-CR	1228101-1228136	36	NC_009329	Geobacillus thermodenitrificans NG80-2 plasmid pLW1071, complete sequence	42559-42594	6	0.833
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NC_009329	Geobacillus thermodenitrificans NG80-2 plasmid pLW1071, complete sequence	42560-42594	6	0.829
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NZ_CP034351	Streptomyces sp. W1SF4 plasmid p1, complete sequence	153058-153092	6	0.829
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NZ_CP051473	Rhodobacter sphaeroides strain CH10 plasmid pRspCH10DE, complete sequence	101567-101601	6	0.829
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NZ_CP030276	Rhodobacter sphaeroides 2.4.1 plasmid pDE, complete sequence	101575-101609	6	0.829
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NZ_CP015289	Rhodobacter sphaeroides strain MBTLJ-20 plasmid a, complete sequence	35742-35776	6	0.829
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NZ_CP015212	Rhodobacter sphaeroides strain MBTLJ-13 plasmid a, complete sequence	100879-100913	6	0.829
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	MN586026	Gordonia phage Leonard, complete genome	33739-33773	6	0.829
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NC_031112	Gordonia phage Phinally, complete genome	33736-33770	6	0.829
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	NC_001949	Lactococcus lactis DPC3147 plasmid pMRC01, complete sequence	9047-9076	7	0.767
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	NZ_CP031445	Acinetobacter baumannii strain MDR-UNC plasmid unnamed1, complete sequence	76363-76392	7	0.767
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	NZ_CP040426	Acinetobacter baumannii strain PB364 plasmid pPB364_1, complete sequence	24891-24920	7	0.767
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	AP014503	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S42-C30, * SEQUENCING IN PROGRESS *, 2 ordered pieces	18782-18811	7	0.767
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	NZ_CP029570	Acinetobacter baumannii strain DA33098 plasmid pDA33098-108, complete sequence	51266-51295	7	0.767
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	NZ_CP027122	Acinetobacter baumannii strain AR_0056 plasmid unnamed1, complete sequence	34528-34557	7	0.767
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	NZ_CP027608	Acinetobacter baumannii strain AR_0102 plasmid unnamed1, complete sequence	34672-34701	7	0.767
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	NZ_CP026705	Acinetobacter baumannii strain AR_0056 plasmid tig00000058_pilon, complete sequence	14727-14756	7	0.767
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	NZ_CP035046	Acinetobacter baumannii strain ABUH793 plasmid p107.0Kbp, complete sequence	35628-35657	7	0.767
NC_019689_2	2.1\|626328\|33\|NC_019689\|CRISPRCasFinder	626328-626360	33	NZ_CP017565	Paraburkholderia sprentiae WSM5005 plasmid pl2WSM5005, complete sequence	438072-438104	7	0.788
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NZ_CP018385	Burkholderia pseudomallei strain 2008724860 plasmid p1, complete sequence	157561-157595	7	0.8
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	NC_029029	Brevibacillus phage Abouo, complete genome	11767-11796	8	0.733
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	NC_022980	Brevibacillus phage Davies, complete genome	11767-11796	8	0.733
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	MN695335	Synechococcus phage B23, complete genome	214889-214918	8	0.733
NC_019689_1	1.3\|41744\|30\|NC_019689\|CRT	41744-41773	30	MN695334	Synechococcus phage B3, complete genome	216186-216215	8	0.733
NC_019689_3	3.29\|1228746\|38\|NC_019689\|PILER-CR	1228746-1228783	38	GU071094	Synechococcus phage S-SM1, complete genome	149467-149504	8	0.789
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NC_021623	Borrelia hermsii strain HS1 plasmid lp174, complete sequence	100707-100741	8	0.771
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NZ_CP014350	Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence	105445-105479	8	0.771
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NZ_CP014350	Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence	106966-107000	8	0.771
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NZ_CP014350	Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence	108369-108403	8	0.771
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NC_006400	Spiroplasma kunkelii CR2-3x plasmid pSKU146, complete sequence	8653-8687	8	0.771
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	AP014353	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S39-C37, * SEQUENCING IN PROGRESS *	606-640	8	0.771
NC_019689_3	3.70\|1228747\|37\|NC_019689\|CRISPRCasFinder,CRT	1228747-1228783	37	GU071094	Synechococcus phage S-SM1, complete genome	149468-149504	8	0.784
NC_019689_3	3.81\|1229539\|35\|NC_019689\|CRISPRCasFinder,CRT	1229539-1229573	35	NZ_CP048628	Megamonas funiformis strain JCM 14723 plasmid putative_Mfuni1, complete sequence	7595-7629	8	0.771
NC_019689_3	3.81\|1229539\|35\|NC_019689\|CRISPRCasFinder,CRT	1229539-1229573	35	NC_041884	Acinetobacter phage vB_AbaM_ME3, complete genome	189384-189418	8	0.771
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	403340-403374	8	0.771
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	618516-618550	8	0.771
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	622423-622457	8	0.771
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	665949-665983	8	0.771
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	CP000664	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA03, complete sequence	65907-65941	8	0.771
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	CP000664	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA03, complete sequence	61392-61426	8	0.771
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	AP017627	Pleomorphomonas sp. SM30 plasmid pSM30-1 DNA, complete genome	4605-4639	8	0.771
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NZ_CP017422	Arthrobacter sp. ZXY-2 plasmid pZXY21, complete sequence	28103-28137	8	0.771
NC_019689_11	11.5\|3805889\|36\|NC_019689\|CRISPRCasFinder,PILER-CR	3805889-3805924	36	NZ_CP031070	Bacillus sp. JAS24-2 plasmid pl278, complete sequence	76014-76049	8	0.778
NC_019689_3	3.20\|1228101\|36\|NC_019689\|PILER-CR	1228101-1228136	36	NZ_CP045276	Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence	106746-106781	9	0.75
NC_019689_3	3.20\|1228101\|36\|NC_019689\|PILER-CR	1228101-1228136	36	NC_021623	Borrelia hermsii strain HS1 plasmid lp174, complete sequence	100707-100742	9	0.75
NC_019689_3	3.20\|1228101\|36\|NC_019689\|PILER-CR	1228101-1228136	36	NZ_CP014350	Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence	105445-105480	9	0.75
NC_019689_3	3.20\|1228101\|36\|NC_019689\|PILER-CR	1228101-1228136	36	NZ_CP014350	Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence	106966-107001	9	0.75
NC_019689_3	3.20\|1228101\|36\|NC_019689\|PILER-CR	1228101-1228136	36	NZ_CP014350	Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence	108369-108404	9	0.75
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NZ_CP045276	Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence	106746-106780	9	0.743
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NZ_CP034857	Buchnera aphidicola (Sitobion avenae) strain Sav plasmid pTrp, complete sequence	912-946	9	0.743
NC_019689_3	3.81\|1229539\|35\|NC_019689\|CRISPRCasFinder,CRT	1229539-1229573	35	MK421971	Klebsiella phage vB_KpnM_GF, partial genome	112370-112404	9	0.743
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NC_015169	Deinococcus proteolyticus MRP plasmid pDEIPR01, complete sequence	199731-199765	9	0.743
NC_019689_3	3.40\|1229538\|36\|NC_019689\|PILER-CR	1229538-1229573	36	MK421971	Klebsiella phage vB_KpnM_GF, partial genome	112369-112404	10	0.722
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NZ_CP031090	Spiroplasma phoeniceum P40 plasmid pSPh387, complete sequence	3334-3368	10	0.714
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NZ_CP031090	Spiroplasma phoeniceum P40 plasmid pSPh387, complete sequence	18379-18413	10	0.714
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NZ_CP031090	Spiroplasma phoeniceum P40 plasmid pSPh387, complete sequence	32645-32679	10	0.714
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NC_017258	Buchnera aphidicola str. Ak (Acyrthosiphon kondoi) plasmid pTrp, complete sequence	2360-2394	10	0.714
NC_019689_3	3.62\|1228174\|33\|NC_019689\|CRISPRCasFinder,CRT	1228174-1228206	33	NZ_LR214986	Mycoplasma cynos strain NCTC10142 plasmid 13	823621-823653	10	0.697
NC_019689_3	3.81\|1229539\|35\|NC_019689\|CRISPRCasFinder,CRT	1229539-1229573	35	MH333064	Klebsiella phage Mineola, complete genome	126318-126352	10	0.714
NC_019689_3	3.81\|1229539\|35\|NC_019689\|CRISPRCasFinder,CRT	1229539-1229573	35	MN434095	Klebsiella pneumoniae phage JIPh_Kp122, complete genome	117002-117036	10	0.714
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NZ_CP016619	Microvirga ossetica strain V5/3m plasmid unnamed2, complete sequence	208140-208174	10	0.714
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	JN116828	Nocardia phage NBR1, complete genome	29275-29309	10	0.714
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	KF879863	UNVERIFIED: Nocardia phage NOC3, partial genome	27920-27954	10	0.714
NC_019689_3	3.21\|1228173\|34\|NC_019689\|PILER-CR	1228173-1228206	34	NZ_LR214986	Mycoplasma cynos strain NCTC10142 plasmid 13	823621-823654	11	0.676
NC_019689_3	3.61\|1228102\|35\|NC_019689\|CRISPRCasFinder,CRT	1228102-1228136	35	NZ_AP018564	Staphylococcus argenteus strain 58113 plasmid p2, complete sequence	16265-16299	11	0.686
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NZ_CP007796	Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence	625995-626029	11	0.686
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NZ_CP032325	Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence	65813-65847	11	0.686
NC_019689_5	5.2\|2419855\|35\|NC_019689\|PILER-CR,CRISPRCasFinder,CRT	2419855-2419889	35	NC_009620	Sinorhizobium medicae WSM419 plasmid pSMED01, complete sequence	583854-583888	11	0.686

1. spacer 1.3|41744|30|NC_019689|CRT matches to MN693129 (Marine virus AFVG_25M62, complete genome) position: , mismatch: 6, identity: 0.8

tgcaattgcaattgtgcttgctttgattcg--	CRISPR spacer
tgcaattgcagttgtgcttgc--agatacagc	Protospacer
**********.**********   *** *.

2. spacer 3.20|1228101|36|NC_019689|PILER-CR matches to NC_009329 (Geobacillus thermodenitrificans NG80-2 plasmid pLW1071, complete sequence) position: , mismatch: 6, identity: 0.833

tttataggttttatttttattaaaattcttccttaa	CRISPR spacer
ttttcaatttttatttttaatataattcttccttaa	Protospacer
*** .*. *********** ** *************

3. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NC_009329 (Geobacillus thermodenitrificans NG80-2 plasmid pLW1071, complete sequence) position: , mismatch: 6, identity: 0.829

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
tttcaatttttatttttaatataattcttccttaa	Protospacer
** .*. *********** ** *************

4. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034351 (Streptomyces sp. W1SF4 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.829

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
tccggccagggccacggccgcggtgcgcgccacca	Protospacer
 ************ *****.********** .**

5. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP051473 (Rhodobacter sphaeroides strain CH10 plasmid pRspCH10DE, complete sequence) position: , mismatch: 6, identity: 0.829

-gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
aaccaggc-gggcctcggccgcggtgcgcgcggctt	Protospacer
 .**.* * ***********.*************.*

6. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030276 (Rhodobacter sphaeroides 2.4.1 plasmid pDE, complete sequence) position: , mismatch: 6, identity: 0.829

-gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
aaccaggc-gggcctcggccgcggtgcgcgcggctt	Protospacer
 .**.* * ***********.*************.*

7. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015289 (Rhodobacter sphaeroides strain MBTLJ-20 plasmid a, complete sequence) position: , mismatch: 6, identity: 0.829

-gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
aaccaggc-gggcctcggccgcggtgcgcgcggctt	Protospacer
 .**.* * ***********.*************.*

8. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015212 (Rhodobacter sphaeroides strain MBTLJ-13 plasmid a, complete sequence) position: , mismatch: 6, identity: 0.829

-gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
aaccaggc-gggcctcggccgcggtgcgcgcggctt	Protospacer
 .**.* * ***********.*************.*

9. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to MN586026 (Gordonia phage Leonard, complete genome) position: , mismatch: 6, identity: 0.829

--gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
gtcccgggca--gcctcggcgccggtgcgcgcggcct	Protospacer
   **** **  ********  ***************

10. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NC_031112 (Gordonia phage Phinally, complete genome) position: , mismatch: 6, identity: 0.829

--gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
gtcccgggca--gcctcggcgccggtgcgcgcggcct	Protospacer
   **** **  ********  ***************

11. spacer 1.3|41744|30|NC_019689|CRT matches to NC_001949 (Lactococcus lactis DPC3147 plasmid pMRC01, complete sequence) position: , mismatch: 7, identity: 0.767

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
gacaattgcaattgagcttgctgtgataat	Protospacer
 .************ ******* ****

12. spacer 1.3|41744|30|NC_019689|CRT matches to NZ_CP031445 (Acinetobacter baumannii strain MDR-UNC plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
agaaattgcacttgcgcttgctttgactga	Protospacer
 * ******* ***.***********.* .

13. spacer 1.3|41744|30|NC_019689|CRT matches to NZ_CP040426 (Acinetobacter baumannii strain PB364 plasmid pPB364_1, complete sequence) position: , mismatch: 7, identity: 0.767

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
agaaattgcacttgcgcttgctttgactga	Protospacer
 * ******* ***.***********.* .

14. spacer 1.3|41744|30|NC_019689|CRT matches to AP014503 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S42-C30, *** SEQUENCING IN PROGRESS ***, 2 ordered pieces) position: , mismatch: 7, identity: 0.767

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
tgcagttgcacttgtgcttgcttacaatat	Protospacer
****.***** ************  * *

15. spacer 1.3|41744|30|NC_019689|CRT matches to NZ_CP029570 (Acinetobacter baumannii strain DA33098 plasmid pDA33098-108, complete sequence) position: , mismatch: 7, identity: 0.767

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
agaaattgcacttgcgcttgctttgactga	Protospacer
 * ******* ***.***********.* .

16. spacer 1.3|41744|30|NC_019689|CRT matches to NZ_CP027122 (Acinetobacter baumannii strain AR_0056 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
agaaattgcacttgcgcttgctttgactga	Protospacer
 * ******* ***.***********.* .

17. spacer 1.3|41744|30|NC_019689|CRT matches to NZ_CP027608 (Acinetobacter baumannii strain AR_0102 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
agaaattgcacttgcgcttgctttgactga	Protospacer
 * ******* ***.***********.* .

18. spacer 1.3|41744|30|NC_019689|CRT matches to NZ_CP026705 (Acinetobacter baumannii strain AR_0056 plasmid tig00000058_pilon, complete sequence) position: , mismatch: 7, identity: 0.767

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
agaaattgcacttgcgcttgctttgactga	Protospacer
 * ******* ***.***********.* .

19. spacer 1.3|41744|30|NC_019689|CRT matches to NZ_CP035046 (Acinetobacter baumannii strain ABUH793 plasmid p107.0Kbp, complete sequence) position: , mismatch: 7, identity: 0.767

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
agaaattgcacttgcgcttgctttgactga	Protospacer
 * ******* ***.***********.* .

20. spacer 2.1|626328|33|NC_019689|CRISPRCasFinder matches to NZ_CP017565 (Paraburkholderia sprentiae WSM5005 plasmid pl2WSM5005, complete sequence) position: , mismatch: 7, identity: 0.788

----ctgtgaaagcgaagccgctatccgagcatgggc	CRISPR spacer
ggggctg----ggcgaagccgctgtccgagcattggc	Protospacer
    ***    .***********.********* ***

21. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018385 (Burkholderia pseudomallei strain 2008724860 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.8

gccggccagggcctcggccacggtgc----gcgcggcct	CRISPR spacer
accggcctgcgcctcggccacggtgcagtagcgcg----	Protospacer
.****** * ****************    *****

22. spacer 1.3|41744|30|NC_019689|CRT matches to NC_029029 (Brevibacillus phage Abouo, complete genome) position: , mismatch: 8, identity: 0.733

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
aataattgcagttgtgcttgctttgtctac	Protospacer
 ..*******.************** .*

23. spacer 1.3|41744|30|NC_019689|CRT matches to NC_022980 (Brevibacillus phage Davies, complete genome) position: , mismatch: 8, identity: 0.733

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
aataattgcagttgtgcttgctttgtctac	Protospacer
 ..*******.************** .*

24. spacer 1.3|41744|30|NC_019689|CRT matches to MN695335 (Synechococcus phage B23, complete genome) position: , mismatch: 8, identity: 0.733

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
aacaattggaattgtgtttgctttgctgaa	Protospacer
 .****** *******.******** *  .

25. spacer 1.3|41744|30|NC_019689|CRT matches to MN695334 (Synechococcus phage B3, complete genome) position: , mismatch: 8, identity: 0.733

tgcaattgcaattgtgcttgctttgattcg	CRISPR spacer
aacaattggaattgtgtttgctttgctgaa	Protospacer
 .****** *******.******** *  .

26. spacer 3.29|1228746|38|NC_019689|PILER-CR matches to GU071094 (Synechococcus phage S-SM1, complete genome) position: , mismatch: 8, identity: 0.789

ttcaacagctcgacgaacagaaaaaagaatttgagcga	CRISPR spacer
ttcaacagttcgacgaaaagaaaaaagaaaaagaatta	Protospacer
********.******** ***********   **.. *

27. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NC_021623 (Borrelia hermsii strain HS1 plasmid lp174, complete sequence) position: , mismatch: 8, identity: 0.771

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
ttttaggttttatgtttattaaaatttattaccaa	Protospacer
** ********** ************. *. ..**

28. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NZ_CP014350 (Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.771

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
ttttaggttttatgtttattaaaatttattaccaa	Protospacer
** ********** ************. *. ..**

29. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NZ_CP014350 (Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.771

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
ttttaggttttatgtttattaaaatttattaccaa	Protospacer
** ********** ************. *. ..**

30. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NZ_CP014350 (Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.771

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
ttttaggttttatgtttattaaaatttattaccaa	Protospacer
** ********** ************. *. ..**

31. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NC_006400 (Spiroplasma kunkelii CR2-3x plasmid pSKU146, complete sequence) position: , mismatch: 8, identity: 0.771

ttataggttttatttttattaaaattc---ttccttaa	CRISPR spacer
agatagtttttatttttatcaaaattcaatttgct---	Protospacer
  **** ************.*******   ** **

32. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to AP014353 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S39-C37, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.771

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
tcatttcttttatttttatagaaattcttcctaac	Protospacer
*.**   ************ .*********** *

33. spacer 3.70|1228747|37|NC_019689|CRISPRCasFinder,CRT matches to GU071094 (Synechococcus phage S-SM1, complete genome) position: , mismatch: 8, identity: 0.784

tcaacagctcgacgaacagaaaaaagaatttgagcga	CRISPR spacer
tcaacagttcgacgaaaagaaaaaagaaaaagaatta	Protospacer
*******.******** ***********   **.. *

34. spacer 3.81|1229539|35|NC_019689|CRISPRCasFinder,CRT matches to NZ_CP048628 (Megamonas funiformis strain JCM 14723 plasmid putative_Mfuni1, complete sequence) position: , mismatch: 8, identity: 0.771

ttgaaaaatcatttcaatttcctcaaaaattaata	CRISPR spacer
tggagttgtcattgctatttcctcaaaaattaaaa	Protospacer
* **.  .***** * ***************** *

35. spacer 3.81|1229539|35|NC_019689|CRISPRCasFinder,CRT matches to NC_041884 (Acinetobacter phage vB_AbaM_ME3, complete genome) position: , mismatch: 8, identity: 0.771

ttgaaaaa-----tcatttcaatttcctcaaaaattaata	CRISPR spacer
-----aaactttttcatttcaatttccttaaaaaataaaa	Protospacer
     ***     ***************.***** *** *

36. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 8, identity: 0.771

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
ggcaaggcgggcctcggccgcggtgcgcgcggctt	Protospacer
* *..   ***********.*************.*

37. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 8, identity: 0.771

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
ggcaaggcgggcctcggccgcggtgcgcgcggctt	Protospacer
* *..   ***********.*************.*

38. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 8, identity: 0.771

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
ggcaaggcgggcctcggccgcggtgcgcgcggctt	Protospacer
* *..   ***********.*************.*

39. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 8, identity: 0.771

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
ggcaaggcgggcctcggccgcggtgcgcgcggctt	Protospacer
* *..   ***********.*************.*

40. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to CP000664 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA03, complete sequence) position: , mismatch: 8, identity: 0.771

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
ggcaaggcgggcctcggccgcggtgcgcgcggctt	Protospacer
* *..   ***********.*************.*

41. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to CP000664 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA03, complete sequence) position: , mismatch: 8, identity: 0.771

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
ggcaaggcgggcctcggccgcggtgcgcgcggctt	Protospacer
* *..   ***********.*************.*

42. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to AP017627 (Pleomorphomonas sp. SM30 plasmid pSM30-1 DNA, complete genome) position: , mismatch: 8, identity: 0.771

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
gcgctcggcggcctcggcggcggtgcgcgcggcct	Protospacer
**   * . ********* .***************

43. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017422 (Arthrobacter sp. ZXY-2 plasmid pZXY21, complete sequence) position: , mismatch: 8, identity: 0.771

--gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
gatccagccgga--ctcggccacgatgcgcgcggccc	Protospacer
   **.***.*.  **********.***********.

44. spacer 11.5|3805889|36|NC_019689|CRISPRCasFinder,PILER-CR matches to NZ_CP031070 (Bacillus sp. JAS24-2 plasmid pl278, complete sequence) position: , mismatch: 8, identity: 0.778

atttgtgtttaaaaatttattgcatccatcaccgct	CRISPR spacer
acttctttttaaaaatttattgcatccataagtgtg	Protospacer
*.** * ********************** * .*.

45. spacer 3.20|1228101|36|NC_019689|PILER-CR matches to NZ_CP045276 (Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence) position: , mismatch: 9, identity: 0.75

tttataggttttatttttattaaaattcttccttaa	CRISPR spacer
tttataggttttatatttatttaaatagtatttttc	Protospacer
************** ****** ****  * ..**

46. spacer 3.20|1228101|36|NC_019689|PILER-CR matches to NC_021623 (Borrelia hermsii strain HS1 plasmid lp174, complete sequence) position: , mismatch: 9, identity: 0.75

tttataggttttatttttattaaaattcttccttaa	CRISPR spacer
gttttaggttttatgtttattaaaatttattaccaa	Protospacer
 ** ********** ************. *. ..**

47. spacer 3.20|1228101|36|NC_019689|PILER-CR matches to NZ_CP014350 (Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.75

tttataggttttatttttattaaaattcttccttaa	CRISPR spacer
gttttaggttttatgtttattaaaatttattaccaa	Protospacer
 ** ********** ************. *. ..**

48. spacer 3.20|1228101|36|NC_019689|PILER-CR matches to NZ_CP014350 (Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.75

tttataggttttatttttattaaaattcttccttaa	CRISPR spacer
gttttaggttttatgtttattaaaatttattaccaa	Protospacer
 ** ********** ************. *. ..**

49. spacer 3.20|1228101|36|NC_019689|PILER-CR matches to NZ_CP014350 (Borrelia hermsii HS1 isolate Browne Mountain plasmid megaplasmid, complete sequence) position: , mismatch: 9, identity: 0.75

tttataggttttatttttattaaaattcttccttaa	CRISPR spacer
gttttaggttttatgtttattaaaatttattaccaa	Protospacer
 ** ********** ************. *. ..**

50. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NZ_CP045276 (Bacillus megaterium strain FDU301 plasmid pFDU301D, complete sequence) position: , mismatch: 9, identity: 0.743

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
ttataggttttatatttatttaaatagtatttttc	Protospacer
************* ****** ****  * ..**

51. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NZ_CP034857 (Buchnera aphidicola (Sitobion avenae) strain Sav plasmid pTrp, complete sequence) position: , mismatch: 9, identity: 0.743

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
ttgcaggttttatttttattaaaaatttttttcct	Protospacer
**..******************** *.**..*.

52. spacer 3.81|1229539|35|NC_019689|CRISPRCasFinder,CRT matches to MK421971 (Klebsiella phage vB_KpnM_GF, partial genome) position: , mismatch: 9, identity: 0.743

ttgaaaaatcatttcaatttcctcaaaaattaata	CRISPR spacer
ggatacaatcattttaatttcctcaaaacttagtt	Protospacer
  . * ********.************* ***.*

53. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NC_015169 (Deinococcus proteolyticus MRP plasmid pDEIPR01, complete sequence) position: , mismatch: 9, identity: 0.743

gccggccagggcctcggccacggtgcgcgcggcct---	CRISPR spacer
ttcggccagtgcctcggccacggtgggc---atctggg	Protospacer
 .******* *************** **   ..**

54. spacer 3.40|1229538|36|NC_019689|PILER-CR matches to MK421971 (Klebsiella phage vB_KpnM_GF, partial genome) position: , mismatch: 10, identity: 0.722

tttgaaaaatcatttcaatttcctcaaaaattaata	CRISPR spacer
cggatacaatcattttaatttcctcaaaacttagtt	Protospacer
.  . * ********.************* ***.*

55. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NZ_CP031090 (Spiroplasma phoeniceum P40 plasmid pSPh387, complete sequence) position: , mismatch: 10, identity: 0.714

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
agatagtttttatttttgttaaaattcaacttact	Protospacer
  **** **********.*********  *.*

56. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NZ_CP031090 (Spiroplasma phoeniceum P40 plasmid pSPh387, complete sequence) position: , mismatch: 10, identity: 0.714

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
agatagtttttatttttgttaaaattcaacttact	Protospacer
  **** **********.*********  *.*

57. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NZ_CP031090 (Spiroplasma phoeniceum P40 plasmid pSPh387, complete sequence) position: , mismatch: 10, identity: 0.714

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
agatagtttttatttttgttaaaattcaacttact	Protospacer
  **** **********.*********  *.*

58. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NC_017258 (Buchnera aphidicola str. Ak (Acyrthosiphon kondoi) plasmid pTrp, complete sequence) position: , mismatch: 10, identity: 0.714

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
ttgcaggttttatttttattaaaaattttttcccg	Protospacer
**..******************** *.**.... .

59. spacer 3.62|1228174|33|NC_019689|CRISPRCasFinder,CRT matches to NZ_LR214986 (Mycoplasma cynos strain NCTC10142 plasmid 13) position: , mismatch: 10, identity: 0.697

cgagacgaaaatattcctgtcaaaaatcaagcc	CRISPR spacer
aaaaacgaaaatatttctttcaaaaatcttttg	Protospacer
 .*.***********.** *********   .

60. spacer 3.81|1229539|35|NC_019689|CRISPRCasFinder,CRT matches to MH333064 (Klebsiella phage Mineola, complete genome) position: , mismatch: 10, identity: 0.714

ttgaaaaatcatttcaatttcctcaaaaattaata	CRISPR spacer
ggatacgatcattttaatttcctcaaaatttagtt	Protospacer
  . * .*******.************* ***.*

61. spacer 3.81|1229539|35|NC_019689|CRISPRCasFinder,CRT matches to MN434095 (Klebsiella pneumoniae phage JIPh_Kp122, complete genome) position: , mismatch: 10, identity: 0.714

ttgaaaaatcatttcaatttcctcaaaaattaata	CRISPR spacer
ggatacgatcattttaatttcctcaaaatttagtt	Protospacer
  . * .*******.************* ***.*

62. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016619 (Microvirga ossetica strain V5/3m plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.714

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
tttggccagggcctccgccacggcgcgcgtcccgc	Protospacer
 ..************ *******.*****.  * .

63. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to JN116828 (Nocardia phage NBR1, complete genome) position: , mismatch: 10, identity: 0.714

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
gtaggccaggccctgggccacggtgcgcatcttcc	Protospacer
*. ******* *** *************..  .*.

64. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to KF879863 (UNVERIFIED: Nocardia phage NOC3, partial genome) position: , mismatch: 10, identity: 0.714

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
gtaggccaggccctgggccacggtgcgcatcttcc	Protospacer
*. ******* *** *************..  .*.

65. spacer 3.21|1228173|34|NC_019689|PILER-CR matches to NZ_LR214986 (Mycoplasma cynos strain NCTC10142 plasmid 13) position: , mismatch: 11, identity: 0.676

tcgagacgaaaatattcctgtcaaaaatcaagcc	CRISPR spacer
aaaaaacgaaaatatttctttcaaaaatcttttg	Protospacer
  .*.***********.** *********   .

66. spacer 3.61|1228102|35|NC_019689|CRISPRCasFinder,CRT matches to NZ_AP018564 (Staphylococcus argenteus strain 58113 plasmid p2, complete sequence) position: , mismatch: 11, identity: 0.686

ttataggttttatttttattaaaattcttccttaa	CRISPR spacer
ctatatgttttgtttttattaaaattaaatgtatg	Protospacer
.**** *****.**************   . *  .

67. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007796 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence) position: , mismatch: 11, identity: 0.686

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
cttgcgcagggcctcggtcacggtccgcgcgctgg	Protospacer
 ..*  ***********.****** ****** .

68. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032325 (Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence) position: , mismatch: 11, identity: 0.686

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
cttgcgcagggcctcggtcacggttcgcgcgctgg	Protospacer
 ..*  ***********.****** ****** .

69. spacer 5.2|2419855|35|NC_019689|PILER-CR,CRISPRCasFinder,CRT matches to NC_009620 (Sinorhizobium medicae WSM419 plasmid pSMED01, complete sequence) position: , mismatch: 11, identity: 0.686

gccggccagggcctcggccacggtgcgcgcggcct	CRISPR spacer
catttcccgggcctccgccacggtgcgcgccagcg	Protospacer
  .  ** ******* ************** . *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1730475 : 1794198

Bacillus_phage(25.0%)

tRNA,transposase,protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015143290.1\|1730475_1731513_-\|protease	trypsin-like serine protease	NA	NA	NA	NA
WP_015143291.1\|1731640_1731964_-	nitrile hydratase subunit alpha	NA	NA	NA	NA
WP_015143292.1\|1732682_1737872_+	AAA family ATPase	W8CYF6	Bacillus_phage	1.0e-21	30.5
WP_015143293.1\|1738137_1739232_+	response regulator	W8CYM9	Bacillus_phage	8.2e-14	34.9
WP_015143294.1\|1739669_1741244_+	metallophosphoesterase	NA	NA	NA	NA
WP_015143295.1\|1741246_1742182_-	ribose-phosphate diphosphokinase	A0A1V0SKK7	Klosneuvirus	3.5e-37	33.6
WP_015143296.1\|1742298_1742640_-	hypothetical protein	NA	NA	NA	NA
WP_015143298.1\|1743303_1743939_-	phosphoribosylanthranilate isomerase	NA	NA	NA	NA
WP_015143299.1\|1744080_1744356_+	photosystem I reaction center subunit PsaK	C3V6N5	uncultured_virus	3.5e-06	40.8
WP_071880643.1\|1744612_1745089_+	FHA domain-containing protein	NA	NA	NA	NA
WP_015143301.1\|1744976_1745855_-	TlyA family RNA methyltransferase	NA	NA	NA	NA
WP_015143302.1\|1746068_1746962_+	prohibitin family protein	A0A172JI70	Bacillus_phage	1.4e-19	29.5
WP_015143303.1\|1747357_1748131_-	pantothenate kinase	NA	NA	NA	NA
WP_015143304.1\|1748185_1748896_+	SDR family oxidoreductase	A0A0K0KVL6	Prochlorococcus_phage	3.0e-09	43.2
WP_041392994.1\|1749254_1749842_+	hypothetical protein	NA	NA	NA	NA
WP_015143306.1\|1749933_1750716_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.1e-33	40.5
WP_015143307.1\|1751053_1751899_-	ABC transporter permease	NA	NA	NA	NA
WP_015143308.1\|1751919_1752969_-	ABC transporter substrate-binding protein	G3M9Z1	Bacillus_virus	4.6e-14	25.3
WP_015143309.1\|1753091_1753766_-	hydrogenase nickel incorporation protein HypB	NA	NA	NA	NA
WP_015143310.1\|1753850_1754228_-	hydrogenase maturation nickel metallochaperone HypA	NA	NA	NA	NA
WP_015143311.1\|1754326_1755523_-	agmatinase family protein	NA	NA	NA	NA
WP_015143312.1\|1756924_1757233_+	carbon dioxide-concentrating mechanism protein CcmK	NA	NA	NA	NA
WP_015143313.1\|1757364_1757718_+	carbon dioxide-concentrating mechanism protein CcmK	NA	NA	NA	NA
WP_015143314.1\|1757811_1758300_-	hypothetical protein	NA	NA	NA	NA
WP_015143315.1\|1758351_1758840_-	hypothetical protein	NA	NA	NA	NA
WP_015143316.1\|1758894_1759554_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_186005373.1\|1759565_1760300_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_144266096.1\|1760314_1760515_+	hypothetical protein	NA	NA	NA	NA
WP_015143317.1\|1761169_1763779_+	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase	NA	NA	NA	NA
WP_144266097.1\|1763861_1764925_-\|transposase	ISKra4 family transposase	NA	NA	NA	NA
WP_144266098.1\|1765085_1766015_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_015143319.1\|1766061_1766841_+	NNMT/PNMT/TEMT family protein	NA	NA	NA	NA
WP_015143320.1\|1768189_1768774_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_015143321.1\|1768872_1769850_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_015143322.1\|1770153_1770684_+	translation initiation factor IF-3	A0A2L0UZ54	Agrobacterium_phage	5.7e-13	32.3
WP_015143323.1\|1770822_1772538_+	ATP-binding protein	NA	NA	NA	NA
WP_041392998.1\|1772879_1773713_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_015143326.1\|1773838_1774126_-\|protease	ATP-dependent Clp protease adapter ClpS	NA	NA	NA	NA
WP_015143327.1\|1774283_1776965_-	bifunctional acetaldehyde-CoA/alcohol dehydrogenase	NA	NA	NA	NA
WP_041393000.1\|1777335_1778037_+	A/G-specific adenine glycosylase	NA	NA	NA	NA
WP_015143329.1\|1778043_1778457_-	DUF4278 domain-containing protein	NA	NA	NA	NA
WP_015143330.1\|1778521_1778704_-	DUF4278 domain-containing protein	NA	NA	NA	NA
WP_015143331.1\|1778926_1780414_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_015143332.1\|1780653_1782828_+	cation:proton antiporter	NA	NA	NA	NA
WP_015143333.1\|1782824_1783295_+	hypothetical protein	NA	NA	NA	NA
WP_015143334.1\|1783417_1784206_+	YdcF family protein	NA	NA	NA	NA
WP_015143335.1\|1784250_1785099_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_015143336.1\|1785148_1786264_-	ABC transporter permease	NA	NA	NA	NA
WP_015143337.1\|1786316_1788146_-	EAL domain-containing protein	G3MA91	Bacillus_virus	1.2e-22	37.5
WP_015143338.1\|1788142_1791007_-	hybrid sensor histidine kinase/response regulator	A0A1V0SGX0	Hokovirus	6.7e-39	31.7
WP_051036400.1\|1791185_1793138_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.6e-23	30.5
WP_015143340.1\|1793100_1794198_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	NA	NA	NA	NA

DBSCAN-SWA_2

3705319 : 3716743

Bacillus_phage(66.67%)

bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015144959.1\|3705319_3708241_-\|bacteriocin	NHLP bacteriocin export ABC transporter permease/ATPase subunit	W8CYL7	Bacillus_phage	5.4e-28	25.8
WP_015144960.1\|3708337_3710551_-\|bacteriocin	NHLP family bacteriocin export ABC transporter peptidase/permease/ATPase subunit	W8CYL7	Bacillus_phage	5.3e-36	26.4
WP_015144961.1\|3710553_3711990_-\|bacteriocin	NHLP bacteriocin system secretion protein	NA	NA	NA	NA
WP_015144962.1\|3712028_3713126_-	cyclic nucleotide-binding domain-containing protein	NA	NA	NA	NA
WP_015144963.1\|3713219_3713507_-	Mo-dependent nitrogenase C-terminal domain-containing protein	H6WFZ1	Cyanophage	9.7e-07	45.1
WP_015144964.1\|3713548_3713785_-	hypothetical protein	NA	NA	NA	NA
WP_041392259.1\|3715157_3715484_-\|bacteriocin	CTB family bacteriocin	NA	NA	NA	NA
WP_015144967.1\|3715553_3715820_-\|bacteriocin	CTB family bacteriocin	NA	NA	NA	NA
WP_015144968.1\|3716473_3716743_-\|bacteriocin	CTB family bacteriocin	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_019689

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

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Click the colored protein region to show detailed information

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection