CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_019752	Calothrix sp. PCC 6303 plasmid pCAL6303.03, complete sequence	0 crisprs	NA	0	0	0	0
NC_019728	Calothrix sp. PCC 6303 plasmid pCAL6303.02, complete sequence	1 crisprs	NA	0	1	0	0
NC_019751	Calothrix sp. PCC 6303, complete sequence	22 crisprs	cas1,cas2,WYL,cas10,cmr4gr7,cmr5gr11,csx1,Cas14c_CAS-V-F,2OG_CAS,cas14j,DinG,cas3,csa3,c2c9_V-U4,PD-DExK,c2c5_V-U5,cas10d,csc2gr7,csc1gr5,cas6,cas4,cas14k,RT	5	10	4	0
NC_019727	Calothrix sp. PCC 6303 plasmid pCAL6303.01, complete sequence	2 crisprs	NA	2	2	0	0

1. NC_019727

CRISPR-Cas detection and classification

Crispr_ID: NC_019727_1

• CRISPR_ID: NC_019727_1
• CRISPR_location: 791-907
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_019727_1

Consensus_repeat	Method
TTCAACCAGGATTAATTGCAACT	CRISPRCasFinder

spacers of NC_019727_1

>1.1|814|31|NC_019727|CRISPRCasFinder
ATAATTGCGCTTCAACCAGGATTAATTGCAA
>1.2|868|17|NC_019727|CRISPRCasFinder
AACCTGCAATCATCGGT

CRISPR arrays and Neighbor proteins around NC_019727_1

CRISPR arrays

The CRISPR arrays of NC_019727_1

>merge|NC_019727|1|791-907|CRISPRCasFinder
CCAAACCAGGATTAACTGCAACTATAATTGCGCTTCAACCAGGATTAATTGCAACTGAGCCAGGATTAAATGCAACCAACCTGCAATCATCGGTTTCAACCAGGATTATTTGCAACT

>NC_019727|1|1|791-907|CRISPRCasFinder
CCAAACCAGGATTAACTGCAACT	ATAATTGCGCTTCAACCAGGATTAATTGCAA
CTGAGCCAGGATTAAATGCAACC	AACCTGCAATCATCGGT
TTCAACCAGGATTATTTGCAACT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019727.1|WP_015173887.1|1202_1772_+|recombinase-family-protein	unknown	unknown	gnl|CDD|239737
NC_019727.1|WP_015173890.1|4626_5010_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379154
NC_019727.1|WP_083866410.1|1776_3423_+|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl|CDD|366234
NC_019727.1|WP_158333194.1|5976_7167_+|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|319251
NC_019727.1|WP_015173891.1|5198_5972_+|ParA-family-protein	unknown	unknown	gnl|CDD|224113
NC_019727.1|WP_041741187.1|73_757_-|IS630-family-transposase	unknown	unknown	gnl|CDD|315923
NC_019727.1|WP_015173893.1|7334_8369_+|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|319251
NC_019727.1|WP_015173896.1|15935_16346_-|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_015173889.1|3412_4384_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|225806
NC_019727.1|WP_015173894.1|8365_10021_-|ISKra4-like-element-ISCasp2-family-transposase	unknown	unknown	unknown
NC_019727.1|WP_015173895.1|10658_15362_-|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|350679

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019727.1|WP_015173887.1|1202_1772_+|recombinase-family-protein	gnl|CDD|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	1.65871e-59
NC_019727.1|WP_015173890.1|4626_5010_-|helix-turn-helix-domain-containing-protein	gnl|CDD|379154	pfam13384, HTH_23, Homeodomain-like domain.	1.49983e-09
NC_019727.1|WP_083866410.1|1776_3423_+|DDE-type-integrase/transposase/recombinase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	6.16255e-08
NC_019727.1|WP_158333194.1|5976_7167_+|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|319251	cd16393, SPO0J_N, Thermus thermophilus stage 0 sporulation protein J-like N-terminal domain, ParB family member. Spo0J (stage 0 sporulation protein J) is a ParB family member, a critical component of the ParABS-type bacterial chromosome segregation system. The Spo0J N-terminal region acts in protein-protein interaction and is adjacent to the DNA-binding domain that binds to parS sites. Two Spo0J bind per parS site, and Spo0J interacts with neighbors via the N-terminal domain to form oligomers via an Arginine-rich patch (RRXR). This superfamily represents the N-terminal domain of ParB, a DNA-binding component of the prokaryotic parABS partitioning system. parABS contributes to the efficient segregation of chromosomes and low-copy number plasmids to daughter cells during prokaryotic cell division. The process includes the parA (Walker box) ATPase, the ParB DNA-binding protein and a parS cis-acting DNA sites. Binding of ParB to centromere-like parS sites is followed by non-specific binding to DNA ("spreading", which has been implicated in gene silencing in plasmid P1) and oligomerization of additional ParB molecules near the parS sites. It has been proposed that ParB-ParB cross-linking compacts the DNA, binds to parA via the N-terminal region, and leads to parA separating the ParB-parS complexes and the recruitment of the SMC (structural maintenance of chromosomes) complexes. The ParB N-terminal domain of Bacillus subtilis and other species contains a Arginine-rich ParB Box II with residues essential for bridging of the ParB-parS complexes. The arginine-rich ParB Box II consensus (I[VIL]AGERR[FYW]RA[AS] identified in several species is partially conserved with this family and related families. Mutations within the basic columns particularly debilitate spreading from the parS sites and impair SMC recruitment. The C-terminal domain contains a HTH DNA-binding motif and is the primary homo-dimerization domain, and binds to parS DNA sites. Additional homo-dimerization contacts are found along the N-terminal domain, but dimerization of the N-terminus may only occur after concentration at ParB-parS foci.	1.82087e-40
NC_019727.1|WP_015173891.1|5198_5972_+|ParA-family-protein	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	3.55119e-65
NC_019727.1|WP_041741187.1|73_757_-|IS630-family-transposase	gnl|CDD|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	2.86421e-22
NC_019727.1|WP_015173893.1|7334_8369_+|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|319251	cd16393, SPO0J_N, Thermus thermophilus stage 0 sporulation protein J-like N-terminal domain, ParB family member. Spo0J (stage 0 sporulation protein J) is a ParB family member, a critical component of the ParABS-type bacterial chromosome segregation system. The Spo0J N-terminal region acts in protein-protein interaction and is adjacent to the DNA-binding domain that binds to parS sites. Two Spo0J bind per parS site, and Spo0J interacts with neighbors via the N-terminal domain to form oligomers via an Arginine-rich patch (RRXR). This superfamily represents the N-terminal domain of ParB, a DNA-binding component of the prokaryotic parABS partitioning system. parABS contributes to the efficient segregation of chromosomes and low-copy number plasmids to daughter cells during prokaryotic cell division. The process includes the parA (Walker box) ATPase, the ParB DNA-binding protein and a parS cis-acting DNA sites. Binding of ParB to centromere-like parS sites is followed by non-specific binding to DNA ("spreading", which has been implicated in gene silencing in plasmid P1) and oligomerization of additional ParB molecules near the parS sites. It has been proposed that ParB-ParB cross-linking compacts the DNA, binds to parA via the N-terminal region, and leads to parA separating the ParB-parS complexes and the recruitment of the SMC (structural maintenance of chromosomes) complexes. The ParB N-terminal domain of Bacillus subtilis and other species contains a Arginine-rich ParB Box II with residues essential for bridging of the ParB-parS complexes. The arginine-rich ParB Box II consensus (I[VIL]AGERR[FYW]RA[AS] identified in several species is partially conserved with this family and related families. Mutations within the basic columns particularly debilitate spreading from the parS sites and impair SMC recruitment. The C-terminal domain contains a HTH DNA-binding motif and is the primary homo-dimerization domain, and binds to parS DNA sites. Additional homo-dimerization contacts are found along the N-terminal domain, but dimerization of the N-terminus may only occur after concentration at ParB-parS foci.	7.46018e-42
NC_019727.1|WP_015173889.1|3412_4384_+|AAA-family-ATPase	gnl|CDD|225806	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion].	1.50491e-49
NC_019727.1|WP_015173895.1|10658_15362_-|DEAD/DEAH-box-helicase	gnl|CDD|350679	cd17921, DEXHc_Ski2, DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins. Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	4.64795e-30

Protein sequences

>NC_019727.1|WP_041741187.1|73_757_-|IS630-family-transposase
MQVVTGTQKKGVIWKRARKSHKGKQDPKTREIKQADLDMLQLSAATGEIDLKYLDESGFCMWSEPSYTYYQRGEQKCLEQTKRRGRRLSIIGLLQPLISFVYGLVIGGVNRKSYIQMMEFEAQEAEKVGRIRVIVQDNGPIHRCKEVQQLWTKWESQGLYIFFLPKYCSEMNPIELEWQHLKKDELSGQMFDDELDLAYAVMNGVKARGETGKYSTERIKFNSPPCS
>NC_019727.1|WP_015173887.1|1202_1772_+|recombinase-family-protein
MLIGYARVSTEDQNLDLQMDALRQAGCEKVYTDHISGAKAARPGLLLAFEVARTGDVLVVWRLDRLGRSLKDLIETMETLDKRGIGLSSLQESITTTSGSGRLIFHLFGALAEFERNLISERTTAGLMAARKRGHRGGRPKALDPAKRQLAVKLYTERQHTIIEICKLMGISKPTLYNYVAEIETEHVT
>NC_019727.1|WP_083866410.1|1776_3423_+|DDE-type-integrase/transposase/recombinase
MPTEALINLRHRLDGLPSRCQERRILIEETAALYGVSTDTLYRALRNSSRPKSINRSDSGTPRKLSMTEMERYCEVIAAMKIRTSNKKGRHISTVRAIELLEEFGMETPDGFVQPPKGALTRSTVNYYLKTWGYDTERMTRQPPAVRFQANHSNECWHFDLSPSDLKHVKQPSWVESGKGNPLLMLYSIVDDRSGVCYQEYHCVYGENVEAALRFLFNAMTLKTTDGFPFHGIPEMIYTDNGPIAKSHVFQNVMDCLKIKLVTHMPAGKDGRRVTARSKGKVERPFRTVKEAHETLYHFHEPESDVEANLWLRQYLLHYNDKPHRLEPHSRMEDWLRNTPKSPLREMCSWERFCTYAREPQRRKVGTDARVSVEGVAYEVEPDLAGETVVLWWGLFDNELYVEFNDQRYGPFYPVDGPIPLHRYRKFKKTKTEERADKIADLAKKLGLPRTALDKNADLQFLVDKYKELTPTVTPFNDPDPYQEFTYPTVLLAKLAISDYLAKPLAKLSTEQLAFIDTLLAETLIKKVIIERVRLYFHSNKGGEQNAY
>NC_019727.1|WP_015173889.1|3412_4384_+|AAA-family-ATPase
MLTEVMEHFRLVREFPKAGYYETEHQKQMFKDIKSAIHSGKLVAITGIIGCGKTTTLRRLFEVLEKEGKILVSKSLSVDKDRATLPTLIAALFYDLSTDKEIKIPKDGEKRERELRDLIRKGKKPVALFVDEAHDLHYSTLTGLKRLIEVVEDGGGTLSVVLAGHPKLKNDLRRPTMEEIGYRSTVFSLEGMVGSQREYIEWLVSECTMVDTPIDEILEVEAIELLATRLRTPLQIEQHLTLALEAAYRVAVKPVTTVIVESVLSKQIDDLEPTLTRHGYDVRGLAEQFNTKPSEIKLLFRGQLDPARSRELQEQMLAAGLPL
>NC_019727.1|WP_015173890.1|4626_5010_-|helix-turn-helix-domain-containing-protein
MGARLRVFLTHKQDKTLLNLRTVDVPQKVKDRAEVVRLNAHGWYVEKIAAHFNWTPQTVREVLHKWQKLGLEGLWELPGRGGKTKYKEEDIVFLEECLKKEPRTYNSLQLVQKLKSEACATTSRSQS
>NC_019727.1|WP_015173891.1|5198_5972_+|ParA-family-protein
MSKTRIIALFNQSGGVAKTTLTHNLGYHLAANKRRVLLVDMDPQASLTNFLGIDPETQEKTIYNAIIDEEALFIYPEKIHGMQLAPTNINLSAAELLLPAATAREYRLAEALTPIKDNYDFILIDCPPSLGILSIVSLTAATHLLVPIQCQFKSFLGTDLLLDTVARVKKKLNKNLQIAGFIPTMLDSRTAQETRTLAAVQEQLSQVATIYPAIPKSIAFADASERRIPLAMYDKNHAAVKVMKKIAKELEKLEVKP
>NC_019727.1|WP_158333194.1|5976_7167_+|ParB/RepB/Spo0J-family-partition-protein
MSKKDIAYNAKLKHTKPLDLMFGGEDSDFSEQSSVPTTSDFSEQISGNKTSNTIDREQIKLDPNQPRRYFDPKKLEKLAQSIKELGILEPLLVRPLNDGYYELIAGERRFKAAGIAGLSEVPCIVKEMDDETVKQVQLIENLQREDLNAYEETIGILELLALRLKMTQDEVISLLNRIEKANRKKADKVIRHDSKEQTDNVIHHDSKEQADNVIRHDNDESEDDVIRHNDESEDKKADNVTPSKRKKQANNVIRLEEIEIVNKVFASIGRLSAESFRANRLPLLNLPGDIQQALASGTIEYTKARAIARVKSEPERLQLLDKAINQNLSLTQIKEIILGLESSEQKEIPPEKAASQRVANIGKRLKEAKVWDDVKKRRKLEKLLGDIEKLLDEQAC
>NC_019727.1|WP_015173893.1|7334_8369_+|ParB/RepB/Spo0J-family-partition-protein
MNIILHKVNDSQIGQRREDGYINLTKMAQASNRKLNDYLRLSTAKAFIDKLSADTGIPVSGKNGLVQVHKGGNNKTTQGTWGHPQVAINCGQWCSPEFAVLVSKWVFSWIANAQNPVKENCDGQSPVFDHRSNQFSDVVKAYIESSQALNRAIHTAIHQQTDSLREALKFLDSYNDVTVTVLAAEAKLVEQTCTTSDTVCIDLITLPDEQPRRYFDGQKLEELSHSIKEFGILEPLLVRPLSGGNYELIAGERRLRASQIAGLTSVPVLVREMDDTTTRACRLIENLQREDLNVYEETIGILNLLALQLKTTEDKVISLLNRIEKANRKKADECGSFSKTGNVV
>NC_019727.1|WP_015173894.1|8365_10021_-|ISKra4-like-element-ISCasp2-family-transposase
MKQMHPCLSKDKNGNKYGRMQASRSNPGMFWEEARELFEEIVGWLDSDSICGLEHGEIESKLLDNGYELLRRLLQGYFDKRSQDETDSEWVGKDQAKRTHKKKLSRKLTTIFGTVIANRIGYGGRKINTLFPLDAELNLPAEQYSHGLRQRVAVEVARSGFRETVDIIEKTTAAKIGKRQAEELAYQSAVDFDDFYTYQQAEAVQVEEIGEIVVISADGKGVIVSHSTRAVPSVEVAVRTEDLRPQTQKRAQASSKKLDKRLTKGEKANAKRMATVASVYTINPFVRTVEQIVNPSDEDKKIKRPKPIGKRVWASVAKEPEVVIKEAFDEALHRDPDRQKRFCALVDGNKQQLSLMKKFAKKHHLELTIVLDIIHVIEYLWKAAFVFYSSTDKQAEAWVTKRLKSILEGKSSDVASGMRTSATKRKLTPQERKPVDNCARYLLNNREYLKYHDYLKAGLPIATGVIEGACRHLIKDRMDITGARWSLAGAEAVLRLRSLYISGDWDKYWRFHLHQEHKRNHLALYQGAIPLMKRVAKARCPITPSPLPIPV
>NC_019727.1|WP_015173895.1|10658_15362_-|DEAD/DEAH-box-helicase
MEERRKITKFNRISSWLSDSVSESEDKRYIHRLIKENLSQRDLILDELISIVQKAHDDARYRLRKLAGNSLAPFENSSAIDPTEGYPERLHLQSLKGYFGEIFAGIIAENFAPFGEEDWEVPVFLFRVHVVEFQHLEFLNQTGETAKKRPGRTGDDCLAFRRNSEGVIISSLACEAKCTANHKTNMISEAHEKASAVNIKPVDIPQLIEILQDYDDIVSNEWVNALRVLWLQKVKKNYERCDLVSYICGEHPSAKRQRKAWISTDKAHENYTSGRRLEAVEIHLHDVENLIKAVYVPQTSIILSTNVSAQIVQEPDDLEVTKAKSDVIVEGESLQNEMAQPSNEVIALATEVQNSLAGSTLTPAIAKLYSQHTRLRAGTDGLKGWREDEAGERLNDAIRLIEAAFIKREAGETDWRNGMLRAGEIFEWLSHPQLNPNNLPIRLLAAAIYELAGYPARAAGLLNEDAIEGIESEILRSLLKADFPNLLQLLTKHWTTALSLNVQADTSLLWDDTDTQSHKFNEYIVNQTASSLGILCAEMRWGNEPRLEKAIEKLSSIAKVLLHGHDTYSWLLGKLCAEVTSVYVETSLRKNIEALSSTITQNGGDFLERYLRQSYQNRKALAWRSQICGIERLATAESFALCTPTGSGKTRIAEIAILQSLFFKTNNSNNLSSPFPLVLYLVPSKALATEVESNLSRVLNRTTNKNVIVTGLYGGTDWGPTDAWLTSDKPTVLICTYEKAEALMKFLGPLFIRRVSLIIIDEAHAVQFDGNKDSLQKAENRALRLESLGARLFTYVEQNHSRIIALSAVASETEGALASWIENQTNASPAKTYYRSTRQLIGRLECKPGRGFEIRYDLLDGRRLEFQEGGENNTPFIPRPFQAYPPAGKLEREQSPGKRLRPYLFWAGMHLAAPNEKGQQRAVLISITQQIGGYAEDFLNLLKKDWANVQKPLFFQVPLEAKKIELWEKCLQSCEDYFGKNSREYQLLNKGIVVHHGKMPGLMARLLIDLINERIIHLVLATSTLSEGVNLPFETVLIPNLQRWSRNDEKYVDINSSEFSNLVGRAGRPGFGTEGRSLVILPATESIEQIKDNKERQKSTKIRNQYRSLVNDLTIQDNPSDKIYNPQSPLAQLLLNLEEQWRHISLPNLEDILFTLPEATFGENNFYDDNFITWLEQTAPLSYGNNLSEAESSAIETLDSLDSILLAVIVEIEQLKAKDLSPNELEEQLQKIWQRSFAHYASIEQERLGNLFIKRGKALKTEIYRDVSQRRRLYRTSLPPRDGNQLLTLYPKLKEIFNTGGDYAIWTVEQRLKYIENIVSNLATLSKFKLEESSGKISWNEILRWWLDPNTAAKKPTAKQVSKWHSYISQNFTYRFNWGLGSIIALAIDEAFGGELVESSLENWSQTGLPWIVFWMKELIVWGTLDPVAAYLLAKVEDVTTRKQAEELAQTYYQYISERELEPNEYLNAVNIRNWTEQSFSDVERHLPTPKPPKKIDVNLLKDFSKAPSKNWRVVPVEVGNEIQWFDLAGVPLAICQKPENWQPDFLNTYDFTLDAENRIVSSRVYV
>NC_019727.1|WP_015173896.1|15935_16346_-|hypothetical-protein
MPKNNRVRKSLSFRLQPYEGTPLAEVADYLNGLDKEEATRKIGEILVMAFLPYARLEANKPTSNKLSSTFLIARDMADKHFGVMALALGLDAVYAVATPLTIAGGSLKEVSNQVEEEDSSLIEGKVTATEIGKLFG

Crispr_ID: NC_019727_2

• CRISPR_ID: NC_019727_2
• CRISPR_location: 21270-21396
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019727_2

Consensus_repeat	Method
CAGCCAGATAAACATTACAAATTAAATACCGAGC	CRISPRCasFinder

spacers of NC_019727_2

>2.1|21304|59|NC_019727|CRISPRCasFinder
GCTCAAATAGCCACCAGTTTTTTAATAACGAATTAAGTGCTGACCAGGGAAATAGCCAG

CRISPR arrays and Neighbor proteins around NC_019727_2

CRISPR arrays

The CRISPR arrays of NC_019727_2

>merge|NC_019727|2|21270-21396|CRISPRCasFinder
CAGCCAGATAAACATTACAAATTAAATACCGAGCGCTCAAATAGCCACCAGTTTTTTAATAACGAATTAAGTGCTGACCAGGGAAATAGCCAGCAGCCAGATAAACATTACAAATTAAATGCCGAGC

>NC_019727|2|2|21270-21396|CRISPRCasFinder
CAGCCAGATAAACATTACAAATTAAATACCGAGC	GCTCAAATAGCCACCAGTTTTTTAATAACGAATTAAGTGCTGACCAGGGAAATAGCCAG
CAGCCAGATAAACATTACAAATTAAATGCCGAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019727.1|WP_015173913.1|31878_32580_+|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_015173914.1|33042_35280_+|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_041741194.1|18981_19197_+|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_015173897.1|16438_17731_-|ParM/StbA-family-protein	unknown	unknown	gnl|CDD|212669
NC_019727.1|WP_015173907.1|28271_28457_-|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_015173909.1|29896_30145_+|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_051036839.1|22660_22915_-|hypothetical-protein	unknown	unknown	gnl|CDD|379326
NC_019727.1|WP_015173908.1|28775_29900_+|hypothetical-protein	unknown	unknown	gnl|CDD|212669
NC_019727.1|WP_015173893.1|7334_8369_+|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|319251
NC_019727.1|WP_015173896.1|15935_16346_-|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_015173895.1|10658_15362_-|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|350679
NC_019727.1|WP_015173899.1|18211_18607_+|MobC-family-plasmid-mobilization-relaxosome-protein	unknown	unknown	gnl|CDD|368576
NC_019727.1|WP_015173912.1|31039_31477_+|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_158333194.1|5976_7167_+|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|319251
NC_019727.1|WP_015173911.1|30740_31034_+|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_015173901.1|19199_19907_-|DUF4145-domain-containing-protein	unknown	unknown	gnl|CDD|372658
NC_019727.1|WP_144051160.1|26387_26684_+|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_015173898.1|17867_18143_-|hypothetical-protein	unknown	unknown	unknown
NC_019727.1|WP_015173894.1|8365_10021_-|ISKra4-like-element-ISCasp2-family-transposase	unknown	unknown	unknown
NC_019727.1|WP_144051166.1|22016_22610_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019727.1|WP_158333194.1|5976_7167_+|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|319251	cd16393, SPO0J_N, Thermus thermophilus stage 0 sporulation protein J-like N-terminal domain, ParB family member. Spo0J (stage 0 sporulation protein J) is a ParB family member, a critical component of the ParABS-type bacterial chromosome segregation system. The Spo0J N-terminal region acts in protein-protein interaction and is adjacent to the DNA-binding domain that binds to parS sites. Two Spo0J bind per parS site, and Spo0J interacts with neighbors via the N-terminal domain to form oligomers via an Arginine-rich patch (RRXR). This superfamily represents the N-terminal domain of ParB, a DNA-binding component of the prokaryotic parABS partitioning system. parABS contributes to the efficient segregation of chromosomes and low-copy number plasmids to daughter cells during prokaryotic cell division. The process includes the parA (Walker box) ATPase, the ParB DNA-binding protein and a parS cis-acting DNA sites. Binding of ParB to centromere-like parS sites is followed by non-specific binding to DNA ("spreading", which has been implicated in gene silencing in plasmid P1) and oligomerization of additional ParB molecules near the parS sites. It has been proposed that ParB-ParB cross-linking compacts the DNA, binds to parA via the N-terminal region, and leads to parA separating the ParB-parS complexes and the recruitment of the SMC (structural maintenance of chromosomes) complexes. The ParB N-terminal domain of Bacillus subtilis and other species contains a Arginine-rich ParB Box II with residues essential for bridging of the ParB-parS complexes. The arginine-rich ParB Box II consensus (I[VIL]AGERR[FYW]RA[AS] identified in several species is partially conserved with this family and related families. Mutations within the basic columns particularly debilitate spreading from the parS sites and impair SMC recruitment. The C-terminal domain contains a HTH DNA-binding motif and is the primary homo-dimerization domain, and binds to parS DNA sites. Additional homo-dimerization contacts are found along the N-terminal domain, but dimerization of the N-terminus may only occur after concentration at ParB-parS foci.	1.82087e-40
NC_019727.1|WP_015173897.1|16438_17731_-|ParM/StbA-family-protein	gnl|CDD|212669	cd10227, ParM_like, Plasmid segregation protein ParM and similar proteins. ParM is a plasmid-encoded bacterial homolog of actin, which polymerizes into filaments similar to F-actin, and plays a vital role in plasmid segregation. ParM filaments segregate plasmids paired at midcell into the individual daughter cells. This subfamily also contains Thermoplasma acidophilum Ta0583, an active ATPase at physiological temperatures, which has a propensity to form filaments.	6.87966e-35
NC_019727.1|WP_015173901.1|19199_19907_-|DUF4145-domain-containing-protein	gnl|CDD|372658	pfam13643, DUF4145, Domain of unknown function (DUF4145). This domain is found in a variety of restriction endonuclease enzymes. The exact function of this domain is uncertain.	3.52168e-12
NC_019727.1|WP_051036839.1|22660_22915_-|hypothetical-protein	gnl|CDD|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	0.000591406
NC_019727.1|WP_015173899.1|18211_18607_+|MobC-family-plasmid-mobilization-relaxosome-protein	gnl|CDD|368576	pfam05713, MobC, Bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region. The absence of MobC has several different effects on oriT DNA. Site- and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency of mobilisation. The localized DNA strand separation required for this nicking is less affected, but becomes more sensitive to the level of active DNA gyrase in the cell. In addition, strand separation is not efficiently extended through the region containing the nick site. These effects suggest a model in which MobC acts as a molecular wedge for the relaxosome-induced melting of oriT DNA. The effect of MobC on strand separation may be partially complemented by the helical distortion induced by supercoiling. However, MobC extends the melted region through the nick site, thus providing the single-stranded substrate required for cleavage by MobA.	1.96272e-07
NC_019727.1|WP_015173893.1|7334_8369_+|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|319251	cd16393, SPO0J_N, Thermus thermophilus stage 0 sporulation protein J-like N-terminal domain, ParB family member. Spo0J (stage 0 sporulation protein J) is a ParB family member, a critical component of the ParABS-type bacterial chromosome segregation system. The Spo0J N-terminal region acts in protein-protein interaction and is adjacent to the DNA-binding domain that binds to parS sites. Two Spo0J bind per parS site, and Spo0J interacts with neighbors via the N-terminal domain to form oligomers via an Arginine-rich patch (RRXR). This superfamily represents the N-terminal domain of ParB, a DNA-binding component of the prokaryotic parABS partitioning system. parABS contributes to the efficient segregation of chromosomes and low-copy number plasmids to daughter cells during prokaryotic cell division. The process includes the parA (Walker box) ATPase, the ParB DNA-binding protein and a parS cis-acting DNA sites. Binding of ParB to centromere-like parS sites is followed by non-specific binding to DNA ("spreading", which has been implicated in gene silencing in plasmid P1) and oligomerization of additional ParB molecules near the parS sites. It has been proposed that ParB-ParB cross-linking compacts the DNA, binds to parA via the N-terminal region, and leads to parA separating the ParB-parS complexes and the recruitment of the SMC (structural maintenance of chromosomes) complexes. The ParB N-terminal domain of Bacillus subtilis and other species contains a Arginine-rich ParB Box II with residues essential for bridging of the ParB-parS complexes. The arginine-rich ParB Box II consensus (I[VIL]AGERR[FYW]RA[AS] identified in several species is partially conserved with this family and related families. Mutations within the basic columns particularly debilitate spreading from the parS sites and impair SMC recruitment. The C-terminal domain contains a HTH DNA-binding motif and is the primary homo-dimerization domain, and binds to parS DNA sites. Additional homo-dimerization contacts are found along the N-terminal domain, but dimerization of the N-terminus may only occur after concentration at ParB-parS foci.	7.46018e-42
NC_019727.1|WP_015173908.1|28775_29900_+|hypothetical-protein	gnl|CDD|212669	cd10227, ParM_like, Plasmid segregation protein ParM and similar proteins. ParM is a plasmid-encoded bacterial homolog of actin, which polymerizes into filaments similar to F-actin, and plays a vital role in plasmid segregation. ParM filaments segregate plasmids paired at midcell into the individual daughter cells. This subfamily also contains Thermoplasma acidophilum Ta0583, an active ATPase at physiological temperatures, which has a propensity to form filaments.	1.22869e-20
NC_019727.1|WP_015173895.1|10658_15362_-|DEAD/DEAH-box-helicase	gnl|CDD|350679	cd17921, DEXHc_Ski2, DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins. Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	4.64795e-30

Protein sequences

>NC_019727.1|WP_015173901.1|19199_19907_-|DUF4145-domain-containing-protein
MNIVANYFLLTEPESVYEYSYYPEECGDPHTNKINIEYAVEYNPNDYDDAPNAGCDYSLLLCLACKEVTLRKSCQHDFMDSETIEMGIETLYPPQGLELSYLPSAIQKAYKAALKARSINVDAYAILLGSTLDMVCEERKAEGKDIYEKLKFLAENGEIPNNLVEVVHKIRQLRNVGAHEPFKGLTSKEIPILDDLIRAILEYLYIAPNLARKAVMHLKRIKDKKSKLEDGEIMF
>NC_019727.1|WP_041741194.1|18981_19197_+|hypothetical-protein
MKVVSRVGSDGILHLDVPVGMTNEELEVMVIFQPLKSSVQVETPQTLGWMPGFFEEVIGGWSGEPLERGKF
>NC_019727.1|WP_015173899.1|18211_18607_+|MobC-family-plasmid-mobilization-relaxosome-protein
MGSKTKRDDGVSRKITHPVRFAEDEYEQLKQKAYNARVSVTEFIRRAALRRQVVEPPPPPQINWKLYEELNAIGVNLNQIAKAVNRAVKSGRGANVDAGRLQNLVDRLNAAIRETQMQLLECGVTDDEEED
>NC_019727.1|WP_015173898.1|17867_18143_-|hypothetical-protein
MRVQRIKATWLAFNPRPAHPQASSKTLPRTNFSAVNVVRNNIENGKISDSDNGVDITLLNYLQIYPILIKKNLVTAQAQIKYSFSLSNKSL
>NC_019727.1|WP_015173897.1|16438_17731_-|ParM/StbA-family-protein
MSKACNLYLAVDVGGSQTKIIYQFSDWKSPEYLLMSPGVEQISKSDLKRYFDQLGWVGAPTPQQQAWLEWKSNIFVVGDFVSEFAPQDRIFERKYENALYKVLAAVGTILSKHNIGKKRRGNPESLKVNLNLGLLLPWNEYNDRKRFEEQLELMLKSLKFRGQSWDVNLSHFECRPEGGGLAAIRIKQNGLDWLQKHKVAVLMFGHRNVTAIYFDAGAIKRGDSPLLGFSTFLDDVCSRVSGLERDKLAAAIFEGLYQKSSQVYRDECTVHPEWGQMEAIASLATAKDESLKALEREDIAQAIQLAIPSYWNRIKKWLDKNIPHLPSEVIVGGGAAAFLEPELEEYFNCKADTKYGAPTRQSGKRASAYTSRNFRDHANLVWVEDIQKQIENLFEFNWQDRRQQSVRLIDCFGMFDQLKDMVAEAENANS
>NC_019727.1|WP_015173896.1|15935_16346_-|hypothetical-protein
MPKNNRVRKSLSFRLQPYEGTPLAEVADYLNGLDKEEATRKIGEILVMAFLPYARLEANKPTSNKLSSTFLIARDMADKHFGVMALALGLDAVYAVATPLTIAGGSLKEVSNQVEEEDSSLIEGKVTATEIGKLFG
>NC_019727.1|WP_015173895.1|10658_15362_-|DEAD/DEAH-box-helicase
MEERRKITKFNRISSWLSDSVSESEDKRYIHRLIKENLSQRDLILDELISIVQKAHDDARYRLRKLAGNSLAPFENSSAIDPTEGYPERLHLQSLKGYFGEIFAGIIAENFAPFGEEDWEVPVFLFRVHVVEFQHLEFLNQTGETAKKRPGRTGDDCLAFRRNSEGVIISSLACEAKCTANHKTNMISEAHEKASAVNIKPVDIPQLIEILQDYDDIVSNEWVNALRVLWLQKVKKNYERCDLVSYICGEHPSAKRQRKAWISTDKAHENYTSGRRLEAVEIHLHDVENLIKAVYVPQTSIILSTNVSAQIVQEPDDLEVTKAKSDVIVEGESLQNEMAQPSNEVIALATEVQNSLAGSTLTPAIAKLYSQHTRLRAGTDGLKGWREDEAGERLNDAIRLIEAAFIKREAGETDWRNGMLRAGEIFEWLSHPQLNPNNLPIRLLAAAIYELAGYPARAAGLLNEDAIEGIESEILRSLLKADFPNLLQLLTKHWTTALSLNVQADTSLLWDDTDTQSHKFNEYIVNQTASSLGILCAEMRWGNEPRLEKAIEKLSSIAKVLLHGHDTYSWLLGKLCAEVTSVYVETSLRKNIEALSSTITQNGGDFLERYLRQSYQNRKALAWRSQICGIERLATAESFALCTPTGSGKTRIAEIAILQSLFFKTNNSNNLSSPFPLVLYLVPSKALATEVESNLSRVLNRTTNKNVIVTGLYGGTDWGPTDAWLTSDKPTVLICTYEKAEALMKFLGPLFIRRVSLIIIDEAHAVQFDGNKDSLQKAENRALRLESLGARLFTYVEQNHSRIIALSAVASETEGALASWIENQTNASPAKTYYRSTRQLIGRLECKPGRGFEIRYDLLDGRRLEFQEGGENNTPFIPRPFQAYPPAGKLEREQSPGKRLRPYLFWAGMHLAAPNEKGQQRAVLISITQQIGGYAEDFLNLLKKDWANVQKPLFFQVPLEAKKIELWEKCLQSCEDYFGKNSREYQLLNKGIVVHHGKMPGLMARLLIDLINERIIHLVLATSTLSEGVNLPFETVLIPNLQRWSRNDEKYVDINSSEFSNLVGRAGRPGFGTEGRSLVILPATESIEQIKDNKERQKSTKIRNQYRSLVNDLTIQDNPSDKIYNPQSPLAQLLLNLEEQWRHISLPNLEDILFTLPEATFGENNFYDDNFITWLEQTAPLSYGNNLSEAESSAIETLDSLDSILLAVIVEIEQLKAKDLSPNELEEQLQKIWQRSFAHYASIEQERLGNLFIKRGKALKTEIYRDVSQRRRLYRTSLPPRDGNQLLTLYPKLKEIFNTGGDYAIWTVEQRLKYIENIVSNLATLSKFKLEESSGKISWNEILRWWLDPNTAAKKPTAKQVSKWHSYISQNFTYRFNWGLGSIIALAIDEAFGGELVESSLENWSQTGLPWIVFWMKELIVWGTLDPVAAYLLAKVEDVTTRKQAEELAQTYYQYISERELEPNEYLNAVNIRNWTEQSFSDVERHLPTPKPPKKIDVNLLKDFSKAPSKNWRVVPVEVGNEIQWFDLAGVPLAICQKPENWQPDFLNTYDFTLDAENRIVSSRVYV
>NC_019727.1|WP_015173894.1|8365_10021_-|ISKra4-like-element-ISCasp2-family-transposase
MKQMHPCLSKDKNGNKYGRMQASRSNPGMFWEEARELFEEIVGWLDSDSICGLEHGEIESKLLDNGYELLRRLLQGYFDKRSQDETDSEWVGKDQAKRTHKKKLSRKLTTIFGTVIANRIGYGGRKINTLFPLDAELNLPAEQYSHGLRQRVAVEVARSGFRETVDIIEKTTAAKIGKRQAEELAYQSAVDFDDFYTYQQAEAVQVEEIGEIVVISADGKGVIVSHSTRAVPSVEVAVRTEDLRPQTQKRAQASSKKLDKRLTKGEKANAKRMATVASVYTINPFVRTVEQIVNPSDEDKKIKRPKPIGKRVWASVAKEPEVVIKEAFDEALHRDPDRQKRFCALVDGNKQQLSLMKKFAKKHHLELTIVLDIIHVIEYLWKAAFVFYSSTDKQAEAWVTKRLKSILEGKSSDVASGMRTSATKRKLTPQERKPVDNCARYLLNNREYLKYHDYLKAGLPIATGVIEGACRHLIKDRMDITGARWSLAGAEAVLRLRSLYISGDWDKYWRFHLHQEHKRNHLALYQGAIPLMKRVAKARCPITPSPLPIPV
>NC_019727.1|WP_015173893.1|7334_8369_+|ParB/RepB/Spo0J-family-partition-protein
MNIILHKVNDSQIGQRREDGYINLTKMAQASNRKLNDYLRLSTAKAFIDKLSADTGIPVSGKNGLVQVHKGGNNKTTQGTWGHPQVAINCGQWCSPEFAVLVSKWVFSWIANAQNPVKENCDGQSPVFDHRSNQFSDVVKAYIESSQALNRAIHTAIHQQTDSLREALKFLDSYNDVTVTVLAAEAKLVEQTCTTSDTVCIDLITLPDEQPRRYFDGQKLEELSHSIKEFGILEPLLVRPLSGGNYELIAGERRLRASQIAGLTSVPVLVREMDDTTTRACRLIENLQREDLNVYEETIGILNLLALQLKTTEDKVISLLNRIEKANRKKADECGSFSKTGNVV
>NC_019727.1|WP_158333194.1|5976_7167_+|ParB/RepB/Spo0J-family-partition-protein
MSKKDIAYNAKLKHTKPLDLMFGGEDSDFSEQSSVPTTSDFSEQISGNKTSNTIDREQIKLDPNQPRRYFDPKKLEKLAQSIKELGILEPLLVRPLNDGYYELIAGERRFKAAGIAGLSEVPCIVKEMDDETVKQVQLIENLQREDLNAYEETIGILELLALRLKMTQDEVISLLNRIEKANRKKADKVIRHDSKEQTDNVIHHDSKEQADNVIRHDNDESEDDVIRHNDESEDKKADNVTPSKRKKQANNVIRLEEIEIVNKVFASIGRLSAESFRANRLPLLNLPGDIQQALASGTIEYTKARAIARVKSEPERLQLLDKAINQNLSLTQIKEIILGLESSEQKEIPPEKAASQRVANIGKRLKEAKVWDDVKKRRKLEKLLGDIEKLLDEQAC
>NC_019727.1|WP_144051166.1|22016_22610_-|hypothetical-protein
MELIEAEDAANGEVGCGIPSDKLSKYLDNRSININGENLRQLLREHLGHILTERDFDAIISQVSRHICSMVAEFNESISNVLQTSEVDGDIIEHISNTELKKYFQSELEEFLSKDFIEQIIQRTHSIIHQSVLQPRHSWLSPIWVFKGSEKLYIASSATLHLAIENVKAQYPHIVGELEVVKVGGILAPNQVVEVDY
>NC_019727.1|WP_051036839.1|22660_22915_-|hypothetical-protein
MDNTAPWNRSTINYPPIYKGVGGNLIDFAVVRSNELGYQGRIGLHALPGAIAFYKKLKIGLLDCGPDPDEPDNLVYFETLRRKL
>NC_019727.1|WP_144051160.1|26387_26684_+|hypothetical-protein
MEASNFCQPSNFSTTRCNAHLGRLMVLNVNRRVRSLSSVLGTRALLPSAIAIKLRVQYREGFIPDLEFFGIFPVKAVYDMGFQILGNGFDDVLMMRFR
>NC_019727.1|WP_015173907.1|28271_28457_-|hypothetical-protein
MPSKKPQMTIRVEEDEYQYLEEWAKEEFLSPTQLAKIIIKRAIANKKKEKAANSGRYEQSM
>NC_019727.1|WP_015173908.1|28775_29900_+|hypothetical-protein
MTVEYSNSENWLASVSYCASLRSLELISGKDPGAGYGKAIYGDMTVVVPAAYSLLRNRNINHHETIANSGAWVRYVEGSRSDLKEKQYFWGTAATAQADHTLLHENKALKAELALESILADLAILNVPDGSKLWISLSNHNPEKWEEDIKRKVRGGHTFQHKDPVSREIVTKTIEIAITGIYPEGFGSIAYCLFGNQSLHLDASEIAIALDIGSSTWLITIFNGSGAVIDRHLIEGGCGELHRAIAETLDKRNDGTSLLRKDVKHSPNLVNQGILAGTFTYGGNHLTGKVFKTEYEQCLQTWWDTRIEKFANFVTNSGYLDQAQYLVCWGGGASLPLTQERLTDIGFVTLTEPQFINAQGLKLLTEITLEDISK
>NC_019727.1|WP_015173909.1|29896_30145_+|hypothetical-protein
MSNYASRRITISYFAAEEVCKMAGLPLDVPPQALAGAVEKLIFQFESDRQASSQPKAEPPKTQVVEANKNAIAAMVKGYQSK
>NC_019727.1|WP_015173911.1|30740_31034_+|hypothetical-protein
MSKPIGYYTNYTPGDEGLLAQMQSVWGAQLQELNNADRLWMIYKLAEELCAEFEEALEIEDLTEGVEEAVERSNSELQQSDRLGLIEALVNQVKHSK
>NC_019727.1|WP_015173912.1|31039_31477_+|hypothetical-protein
MGRNKYQLQASLGLFSLFLTASPLFLKLPAQYQAFNKNSEMEVDAAIAYSKTRTSEQIERERIQQRKETADTLQRTGILPTHQKLKIRRYFDNPKRNPNPDITGYLEDETVYVYDSAGICIGRIENRQWYWKHWYKNACDNSPAQ
>NC_019727.1|WP_015173913.1|31878_32580_+|hypothetical-protein
MSALGEKDASQSKKEEQKKGVSEYIEIIAQWVVDIISIPFQFAGAIMSQFVQPGTSGAKILGMLMFAGGVVLSADGIWQTLFQGTPMFPWFERGWIGWFGWLTVWFNPLFWLSIVVSWCIQQAEAKTLRGKKPNLAKTEFDESKQYSLPSKPSGSIDLTKALWGDYKRAGMRERHSGGLIALLIWTLDFVTTFYSRNPFGFTDPGQVMGCIVYNFATMMAGEIGWNLWKHSKR
>NC_019727.1|WP_015173914.1|33042_35280_+|hypothetical-protein
MDFINHQPDSNPHFSPKPATGDGQSDNQSGVTPIKPPVPQLTTPETARLRENYPSIEHLEAGNVAAWLQERQDQLLSRATEGRASMNLAKLITLAGGAVGAVCYATSPIAPIAALIGFGSYIWTVAKDNNATHKFAPVPFIRGSFWEFLSAMGDAEAREEWFSNQDDLLDLLSHMERMERTEYAMLREFKQELTDYLSIVDSGKKFYAYRWLLDCFEQYRGSLPSAKTLKQHLEIVTVDPRTDFEQVNALIQHQSQQQQPRIIDLPPGRINDLPPGKINDSSLGNINDSASRNINDSSLGDINDLSSRKNNDLSPGNIHDLASRKTNDSSLSDINDLASRKTNELSPENIHDLQKSPHNPTTPNRDELLKLPLTARAEAIIKALTEGGFDIAKCIQDQISAIAGNQRGGKGTLMAILAILSFALNPQTKIHYFTAGDDIYPFKCDKLLCRLNWHNLDGSEADAKVAQALFKYLKKMDNATQGEYDDVILVIDEAVALSGYLTDDQKEWMVKYILTRASKKGAQIFVVLHGKHLSTWVGKNTNGMADTFKSGVSFIGCESTSIQVSALKRISVATGRYFLADPDSFDKAVKGGEIGVLPDWIKTEKHPVNGQPDPARTLLTFFPELVDNNPNFDNSSSGEDICETIKVDRSATVESLENLWKLSVPEVDFESEIDEAFLSLILELVAKASAFPVSFEAIRKHKSWERDWGLKNPGRGTLRAALSKLVIEQRLNGNEKEGYLLPNKS

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NC_019727.1	4495-4525	0	1.0
NC_019727_1	1.2|868|17|NC_019727|CRISPRCasFinder	868-884	17	NC_019727.1	4455-4471	1	0.941

1. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to position: 4495-4525, mismatch: 0, identity: 1.0

ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
ataattgcgcttcaaccaggattaattgcaa	Protospacer
*******************************

2. spacer 1.2|868|17|NC_019727|CRISPRCasFinder matches to position: 4455-4471, mismatch: 1, identity: 0.941

aacctgcaatcatcggt	CRISPR spacer
aacctgcaatcatctgt	Protospacer
************** **

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NC_019727	Calothrix sp. PCC 6303 plasmid pCAL6303.01, complete sequence	814-844	0	1.0
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NC_019727	Calothrix sp. PCC 6303 plasmid pCAL6303.01, complete sequence	4495-4525	0	1.0
NC_019727_2	2.1|21304|59|NC_019727|CRISPRCasFinder	21304-21362	59	NC_019727	Calothrix sp. PCC 6303 plasmid pCAL6303.01, complete sequence	21304-21362	0	1.0
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NC_019773	Anabaena cylindrica PCC 7122 plasmid pANACY.03, complete sequence	76281-76311	4	0.871
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NC_019773	Anabaena cylindrica PCC 7122 plasmid pANACY.03, complete sequence	112477-112507	4	0.871
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NC_019774	Anabaena cylindrica PCC 7122 plasmid pANACY.04, complete sequence	80646-80676	4	0.871
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NZ_CP046708	Nostoc sp. ATCC 53789 plasmid pNsp_e, complete sequence	26464-26494	5	0.839
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NC_019773	Anabaena cylindrica PCC 7122 plasmid pANACY.03, complete sequence	72780-72810	5	0.839
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NC_019773	Anabaena cylindrica PCC 7122 plasmid pANACY.03, complete sequence	108976-109006	5	0.839
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NC_019774	Anabaena cylindrica PCC 7122 plasmid pANACY.04, complete sequence	84147-84177	5	0.839
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NC_003273	Nostoc sp. PCC 7120 = FACHB-418 plasmid pCC7120delta, complete sequence	45261-45291	5	0.839
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	NZ_CP016500	Agrobacterium sp. RAC06 plasmid pBSY240_1, complete sequence	233415-233445	6	0.806
NC_019727_1	1.1|814|31|NC_019727|CRISPRCasFinder	814-844	31	AP018324	Nostoc sp. HK-01 plasmid plasmid6 DNA, complete genome	2483-2513	7	0.774

1. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NC_019727 (Calothrix sp. PCC 6303 plasmid pCAL6303.01, complete sequence) position: , mismatch: 0, identity: 1.0

ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
ataattgcgcttcaaccaggattaattgcaa	Protospacer
*******************************

2. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NC_019727 (Calothrix sp. PCC 6303 plasmid pCAL6303.01, complete sequence) position: , mismatch: 0, identity: 1.0

ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
ataattgcgcttcaaccaggattaattgcaa	Protospacer
*******************************

3. spacer 2.1|21304|59|NC_019727|CRISPRCasFinder matches to NC_019727 (Calothrix sp. PCC 6303 plasmid pCAL6303.01, complete sequence) position: , mismatch: 0, identity: 1.0

gctcaaatagccaccagttttttaataacgaattaagtgctgaccagggaaatagccag	CRISPR spacer
gctcaaatagccaccagttttttaataacgaattaagtgctgaccagggaaatagccag	Protospacer
***********************************************************

4. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NC_019773 (Anabaena cylindrica PCC 7122 plasmid pANACY.03, complete sequence) position: , mismatch: 4, identity: 0.871

-ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
aatcatc-cgtttcaaccaggattaattgcaa	Protospacer
 ** **. **.*********************

5. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NC_019773 (Anabaena cylindrica PCC 7122 plasmid pANACY.03, complete sequence) position: , mismatch: 4, identity: 0.871

-ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
aatcatc-cgtttcaaccaggattaattgcaa	Protospacer
 ** **. **.*********************

6. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NC_019774 (Anabaena cylindrica PCC 7122 plasmid pANACY.04, complete sequence) position: , mismatch: 4, identity: 0.871

-ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
aatcatc-cgtttcaaccaggattaattgcaa	Protospacer
 ** **. **.*********************

7. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NZ_CP046708 (Nostoc sp. ATCC 53789 plasmid pNsp_e, complete sequence) position: , mismatch: 5, identity: 0.839

-ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
aatcatc-cgtttcgaccaggattaattgcaa	Protospacer
 ** **. **.***.*****************

8. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NC_019773 (Anabaena cylindrica PCC 7122 plasmid pANACY.03, complete sequence) position: , mismatch: 5, identity: 0.839

-ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
aatcatc-cgtttcaaccaggattatttgcaa	Protospacer
 ** **. **.************** ******

9. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NC_019773 (Anabaena cylindrica PCC 7122 plasmid pANACY.03, complete sequence) position: , mismatch: 5, identity: 0.839

-ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
aatcatc-cgtttcaaccaggattatttgcaa	Protospacer
 ** **. **.************** ******

10. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NC_019774 (Anabaena cylindrica PCC 7122 plasmid pANACY.04, complete sequence) position: , mismatch: 5, identity: 0.839

-ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
aatcatc-cgtttcaaccaggattatttgcaa	Protospacer
 ** **. **.************** ******

11. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NC_003273 (Nostoc sp. PCC 7120 = FACHB-418 plasmid pCC7120delta, complete sequence) position: , mismatch: 5, identity: 0.839

-ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
aatcatc-cgtttcgaccaggattaattgcaa	Protospacer
 ** **. **.***.*****************

12. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to NZ_CP016500 (Agrobacterium sp. RAC06 plasmid pBSY240_1, complete sequence) position: , mismatch: 6, identity: 0.806

ataattgcgcttcaaccaggattaat-tgcaa	CRISPR spacer
agaattgcgcttcaagcaggatgaacatgcg-	Protospacer
* ************* ****** **. ***. 

13. spacer 1.1|814|31|NC_019727|CRISPRCasFinder matches to AP018324 (Nostoc sp. HK-01 plasmid plasmid6 DNA, complete genome) position: , mismatch: 7, identity: 0.774

ataattgcgcttcaaccaggattaattgcaa	CRISPR spacer
ataattacgcttcagccaggattaagggtct	Protospacer
******.*******.**********  *.  

2. NC_019751

CRISPR-Cas detection and classification

Crispr_ID: NC_019751_1

• CRISPR_ID: NC_019751_1
• CRISPR_location: 316560-317384
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 11 spacers
• Cas_protein_info: cas1,cas2,WYL

Consensus repeat of NC_019751_1

Consensus_repeat	Method
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	PILER-CR
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	CRISPRCasFinder
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	CRT

spacers of NC_019751_1

>1.1|316595|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
GAAACTGCTTCTGCTGATTGAGTTAAAAAGGATTTT
>1.2|316666|40|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CTCTGTACCTCTCCCCTGTATCGTTGCGCATAGATTGCGA
>1.3|316741|37|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TAGATATTTTCTCTATTTCACGACCATCTTTTTTAAT
>1.4|316813|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TTGAAGTTTCCGTCTGTTACAAAATCATCTAAATTG
>1.5|316884|37|NC_019751|PILER-CR,CRISPRCasFinder,CRT
GAGGATAAATTTAAAAAGAATGAAGTCGATACGATCA
>1.6|316956|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
GAAATGGATAATTTTTGACCGAATACCACTTTTCT
>1.7|317026|37|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TATATGATTCGCTGCTAAAGTATTTTTCAACCTTCTT
>1.8|317098|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TTTTTACTCTTTCAAAATAAGAGTCAAAATTTTTT
>1.9|317168|38|NC_019751|PILER-CR,CRISPRCasFinder,CRT
AGTAGCACAATCCCATTCAGTAATTGCACATACTTTTC
>1.10|317241|37|NC_019751|PILER-CR,CRISPRCasFinder,CRT
ATTGTTTGCCACATATTCTGAAAATAAAACACGAGTT
>1.11|317313|37|NC_019751|PILER-CR,CRISPRCasFinder,CRT
ACATTTAACAAATTATTTTGTCAAATCTGAAAAATCA

CRISPR arrays and Neighbor proteins around NC_019751_1

CRISPR arrays

The CRISPR arrays of NC_019751_1

>merge|NC_019751|1|316560-317384|PILER-CR,CRISPRCasFinder,CRT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACGAAACTGCTTCTGCTGATTGAGTTAAAAAGGATTTTCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACCTCTGTACCTCTCCCCTGTATCGTTGCGCATAGATTGCGACTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACTAGATATTTTCTCTATTTCACGACCATCTTTTTTAATCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACTTGAAGTTTCCGTCTGTTACAAAATCATCTAAATTGCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACGAGGATAAATTTAAAAAGAATGAAGTCGATACGATCACTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACGAAATGGATAATTTTTGACCGAATACCACTTTTCTCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACTATATGATTCGCTGCTAAAGTATTTTTCAACCTTCTTCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACTTTTTACTCTTTCAAAATAAGAGTCAAAATTTTTTCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACAGTAGCACAATCCCATTCAGTAATTGCACATACTTTTCCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACATTGTTTGCCACATATTCTGAAAATAAAACACGAGTTCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACACATTTAACAAATTATTTTGTCAAATCTGAAAAATCACTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC

>NC_019751|1|1|316560-317384|PILER-CR
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	GAAACTGCTTCTGCTGATTGAGTTAAAAAGGATTTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	CTCTGTACCTCTCCCCTGTATCGTTGCGCATAGATTGCGA
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TAGATATTTTCTCTATTTCACGACCATCTTTTTTAAT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TTGAAGTTTCCGTCTGTTACAAAATCATCTAAATTG
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	GAGGATAAATTTAAAAAGAATGAAGTCGATACGATCA
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	GAAATGGATAATTTTTGACCGAATACCACTTTTCT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TATATGATTCGCTGCTAAAGTATTTTTCAACCTTCTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TTTTTACTCTTTCAAAATAAGAGTCAAAATTTTTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	AGTAGCACAATCCCATTCAGTAATTGCACATACTTTTC
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	ATTGTTTGCCACATATTCTGAAAATAAAACACGAGTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	ACATTTAACAAATTATTTTGTCAAATCTGAAAAATCA
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC

>NC_019751|1|1|316560-317384|CRISPRCasFinder
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	GAAACTGCTTCTGCTGATTGAGTTAAAAAGGATTTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	CTCTGTACCTCTCCCCTGTATCGTTGCGCATAGATTGCGA
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TAGATATTTTCTCTATTTCACGACCATCTTTTTTAAT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TTGAAGTTTCCGTCTGTTACAAAATCATCTAAATTG
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	GAGGATAAATTTAAAAAGAATGAAGTCGATACGATCA
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	GAAATGGATAATTTTTGACCGAATACCACTTTTCT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TATATGATTCGCTGCTAAAGTATTTTTCAACCTTCTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TTTTTACTCTTTCAAAATAAGAGTCAAAATTTTTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	AGTAGCACAATCCCATTCAGTAATTGCACATACTTTTC
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	ATTGTTTGCCACATATTCTGAAAATAAAACACGAGTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	ACATTTAACAAATTATTTTGTCAAATCTGAAAAATCA
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC

>NC_019751|1|1|316560-317384|CRT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	GAAACTGCTTCTGCTGATTGAGTTAAAAAGGATTTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	CTCTGTACCTCTCCCCTGTATCGTTGCGCATAGATTGCGA
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TAGATATTTTCTCTATTTCACGACCATCTTTTTTAAT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TTGAAGTTTCCGTCTGTTACAAAATCATCTAAATTG
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	GAGGATAAATTTAAAAAGAATGAAGTCGATACGATCA
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	GAAATGGATAATTTTTGACCGAATACCACTTTTCT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TATATGATTCGCTGCTAAAGTATTTTTCAACCTTCTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	TTTTTACTCTTTCAAAATAAGAGTCAAAATTTTTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	AGTAGCACAATCCCATTCAGTAATTGCACATACTTTTC
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	ATTGTTTGCCACATATTCTGAAAATAAAACACGAGTT
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC	ACATTTAACAAATTATTTTGTCAAATCTGAAAAATCA
CTTTAAACTTCTTCGGAAGTTGAATTAATGGAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_158333119.1|316385_316526_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|376633
NC_019751.1|WP_015196020.1|313459_314212_-|DUF4384-domain-containing-protein	unknown	unknown	gnl|CDD|379557
NC_019751.1|WP_015196027.1|320450_320843_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196017.1|307408_308317_-|M48-family-metalloprotease	unknown	unknown	gnl|CDD|320683
NC_019751.1|WP_015196024.1|319267_319537_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_068972685.1|309454_313111_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|378942
NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl|CDD|379324
NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_019751.1|WP_041738925.1|329011_329272_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196021.1|314349_316356_+|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|376633
NC_019751.1|WP_015196014.1|303797_303959_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196018.1|308554_309154_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_085953333.1|322570_323808_-|ISAzo13-family-transposase	unknown	unknown	gnl|CDD|369439
NC_019751.1|WP_015196025.1|319633_319933_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196015.1|304143_306417_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|379062
NC_019751.1|WP_015196016.1|306437_306971_-|glycine-rich-domain-containing-protein-like	unknown	unknown	gnl|CDD|226728
NC_019751.1|WP_144051089.1|322012_322243_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196013.1|303003_303693_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196028.1|321419_321713_+|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	2.5e-49	162.7	1.6
NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	1.8e-20	68.4	0.0
NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.5e-28	93.6	0.6
NC_019751.1|WP_015196021.1|314349_316356_+|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	2.9e-93	307.0	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015196015.1|304143_306417_+|AAA-family-ATPase	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	8.65037e-07
NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1	gnl|CDD|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	9.09473e-58
NC_019751.1|WP_015196021.1|314349_316356_+|CRISPR-associated-endonuclease-Cas1	gnl|CDD|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	2.7683e-111
NC_019751.1|WP_015196017.1|307408_308317_-|M48-family-metalloprotease	gnl|CDD|320683	cd07324, M48C_Oma1-like, Oma1 peptidase-like, integral membrane metallopeptidase. This family contains peptidase M48 subfamily C (also known as Oma1 peptidase or mitochondrial metalloendopeptidase OMA1), including similar peptidases containing tetratricopeptide (TPR) repeats, as well as uncharacterized proteins such as E. coli bepA (formerly yfgC), ycaL and loiP (formerly yggG), considered to be putative metallopeptidases. Oma1 peptidase is part of the quality control system in the inner membrane of mitochondria, with its catalytic site facing the matrix space. It cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins. Oma1 can cleave the misfolded multi-pass membrane protein Oxa1, thus exerting a function similar to the ATP-dependent m-AAA protease for quality control of inner membrane proteins. It has been proposed that in the absence of m-AAA protease, proteolysis of Oxa1 is mediated by Oma1 in an ATP-independent manner. Homologs of Oma1 are present in higher eukaryotes, eubacteria and archaebacteria, suggesting that Oma1 is the founding member of a conserved family of membrane-embedded metallopeptidases, all containing the zinc metalloprotease motif (HEXXH). M48 peptidases proteolytically remove the C-terminal three residues of farnesylated proteins.	7.97819e-32
NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein	gnl|CDD|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	2.18109e-20
NC_019751.1|WP_068972685.1|309454_313111_-|tetratricopeptide-repeat-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	3.27477e-41
NC_019751.1|WP_015196016.1|306437_306971_-|glycine-rich-domain-containing-protein-like	gnl|CDD|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	9.14039e-06
NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.11877e-27
NC_019751.1|WP_085953333.1|322570_323808_-|ISAzo13-family-transposase	gnl|CDD|369439	pfam07592, DDE_Tnp_ISAZ013, Rhodopirellula transposase DDE domain. These transposases are found in the planctomycete Rhodopirellula baltica, the cyanobacterium Nostoc, and the Gram-positive bacterium Streptomyces.	6.49222e-78
NC_019751.1|WP_015196020.1|313459_314212_-|DUF4384-domain-containing-protein	gnl|CDD|379557	pfam14326, DUF4384, Domain of unknown function (DUF4384). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.	4.40526e-19

Protein sequences

>NC_019751.1|WP_158333119.1|316385_316526_+|hypothetical-protein
MAETLILSFYPTNRYPGKGLMLLEYGLITKNYQLFRKNFTPHKKWR
>NC_019751.1|WP_015196021.1|314349_316356_+|CRISPR-associated-endonuclease-Cas1
MFTLEHLNYAWLQVRAGSKSAGVDGISIGFFESMATEQLRNLVSQLQYGTYTASPAKGFYVPKKNGGKRLIGIPTVRDRIIQRLLLDELYFPLEDTFVDCSYAYRPGRNIQQAVQHLYRYYQYQPKWIIKADIVEFFDNICLALLLNALEKLRLEPNILQLIEQQIKSGIIINGQYQNAGKGLLQGGTLSGALANLYLTDFDQKCLNQGINLVRYGDDFVIACSNFAEANRVLDKITGWLGGVYLTLKAEKTEIFSPDDEFTFLGYRFAKGEVFAPPPPEPTQQGEWVINDSGTPYFRRKPKPEKPVSRPPKACSIDKPVNFPRAAISHYWQDFMSTLYVTDQGAYLSMKNQQFQVFYQGELKIKIPVVRVSSIVMFGCCNVSHGAVSMALIRRIPIMYLSQKGRYFGHTAVQGNAKVEYLMKQVICCQNPVFTRQQAETIVAAKLHNSRILLMRLNRRRETEIATQAIDFIEILIDSLPKAESMDALRGYEGKAATIYFQALGSLFTGFFAFDKRTKRPPTDPINSLMSLGYTLLSQQVFSFVQSVGLHTHFGNLHVPRDNHPALVSDLMEEFRAQIVDSFVSYIVNKKILTPEDFTSPDERGGVYLQASALKKYLKHWEEKLQSETTHPNTGYKVAYRRCIELQVREYVACLVGEVEVYRPMTWKM
>NC_019751.1|WP_015196020.1|313459_314212_-|DUF4384-domain-containing-protein
MSKRSLVASGAGIKLAKQALERKSLTQKALTVEVGLSWATVNNFFNQKPIDRINFEEICTFLDLEWHDIVAPFAEKEEVVQQTPLEKIWQQLTALGSPTEQMGLVLVKEETLGWGKKIGSYYEKSVRLGNYIQFEINLQTPGYLLLIQKDTCGQIWCFCPSPFAPQPQLENGKTSLPQMGSPMTAFPVEGKPGKEQILAIISPSIPNLQWLLQDSDEVLELTESHLMELISYVNKNDGNQILYTEYQILK
>NC_019751.1|WP_068972685.1|309454_313111_-|tetratricopeptide-repeat-protein
MSEIIETITQLNREVVKLAEAGDFEASISIAKEAVKLGEKNIDEHPAFADSLNNLAELYRMQGYFVEAKPLYIKILNLRKRLLGDSHPDVAQSLNNLAAFYVSQGLFIEAENYFLAALDIWKIYLGDEHPEIATNLNNIAEVYREQGRFQESEKIHLQALNMRKRLFGDFHADIAQSLDNLAVIYENQARYSEAETTHLEALEIRREIFGDENWQIAASLNNLAALYNSQGRFVEAAENYSQALELCKNCLGNEEHPYIAITLNNLANTYKNQGHYAEAEKTHFQALSMRKNIFGDEHLEVAQSLSNLGDIYLIQGRYLDAEEVYLQADSIKKDLLNPEHPDIALSLHNLGVLYTYQGRYQQAEAKYLEALSLHEQSLGKNHPIVADNLNHLGSLYQEQGLFSDAEQKYLAALAIRKNIFGEEHPDIADSYNKIAEIYRLQGRYSQAEGLYLEAYKLNKKLLGEIHPDVAAILSNLGVLYDAQFKYSQAEPLFTEALLIVRTKFGDNHPQVASVLNNLAAIYGSMRRYLEAEEIHLQVLEIRKSIFGSEHPDIANTLNNLAEIYLAQGKYAEAEKYYSSALSVRIKFLGENHPDVALSLNNLATLYAATKRPDNALSHRIQASTIHDKLISNVFAFSSENDRLAFIDKIRGNFDLFLSLIYQYFPNSETATQEAFDFILKRKGLTAASLAAQSQAFYNDRYPQLTGKFRQLSELNTQLVRLTSFANQTQNIANYQSNLTQLRSQYDNLQKQIASQVPEIQLSTQIPNRHAVASALPTKSVLIEFVLFDVFDFQAIQANGETQWKSPHYLAFILPAGQADGVQMVDLGEADTIHNLINLFRLEASDGGEETLGWAKVKTTPQLQIKQYNPAAAVELSQIILSPILDVLTDCDQIIFAPDGNLNLVPLQILPIYPSERSFLMDKYTVSYLGVGRDIIHSQHQPTTIGDTPIIIADPDFDLAMANNNLPNLENPTKQELLDTLDIKLDIKVLPPAHGTRLLGASVAKKLKNARLYTGAKALSTCLTNSKCPSIMLIATHGLFIPDSRQSNPMMRSAVAFAGANTALLGGNLPKQAGNGFIFAQDIAGLDLRANELTVLSACDTARGDIKIGEGVFGLRRAFASSGTKILVMSLWEVPGRATALLMEQFFEHYQNGVAAVEALQNAQNYIRNITVEELRKSDLGMEILTELSQVRGLEISTNGNKKPLEHPFYWGAWICQGL
>NC_019751.1|WP_015196018.1|308554_309154_-|hypothetical-protein
MKSWKLSVATVVLVASVCIPKAEAKNLSNTQANQVKQTFSVLANNSQVIKEPSLIAINDTYRGPNQDFEIQMPGSVQENEERKLMSWSDTTQTVYVIIHKDMPVDVSYLSVEEVEQVLQTSMREEMASTGKIVRSTNLEIDGYPGLELLVQHTDGTTGQYRGFIVKGRMYVMGAATQGELTTEAVNFFDSFGVYPERVR
>NC_019751.1|WP_015196017.1|307408_308317_-|M48-family-metalloprotease
MKTSHIKSIRKIIFTTLGFSSSILLSLNTPGFAQALITLPDLSITNSSISTSQVKPKKTNLQWVYSVAEKVIRANGLDEHPWRFQVSDEYNINAYAGELNKIVIYKGLLDQIHGDDAALAFIIAHELAHHTQRHSAQQEEAEARLKDKLLKEAEAEFTSWIVAEKQKSQKPISIAEKDVIKQRILIQKKQEFDQAIQALSRQHEFQADAVGYTYMGKAGYDPNGGLRVFNLFHRLPSDYTENSTHPTTEQRIDALNQVMNKYPWRTLWADGNERLKVNSQPLKFDVIENGISLRINSKFLSE
>NC_019751.1|WP_015196016.1|306437_306971_-|glycine-rich-domain-containing-protein-like
MNTIWEKQLPSKTNEEFAEKITNFFRKLNQLDFRAISKKLTSNTENFQWTEEETKSAIHLYKMFLCLHFLFPNTELVPTVEIDRVWHTHILLNTAKYIEDCQELYGYILHHYSPADDDLEISHKFQKTAFDLTKHLFLEIFGIDICHNVAYHQGRCLILPQHFPQLQRSACLTIPKS
>NC_019751.1|WP_015196015.1|304143_306417_+|AAA-family-ATPase
MLSRNFLSQIAYEHELSPEQQQVFLMRIGDGLSYEEIAAQLNTSADACLKRMGQVYKKFNISGASRGKESKLRFFLTNRLEKVTEESSAHTQSIEEKKQETQPNSVAQNLPVREYTTFVGRDQEITRLMELLDFQHTAHLISVDGIGGVGKTTLVVEVAYRCLQASNNQLLTPNLPTFEAIIFTSAKQNHLTSIGILPRLTKERTLRDICREVARILDLSEITNLPIEEQFQPIREKLSQTRTLLIVDNLETIENQQEVLSFLYDLPPSVKVIITTREQALFVPIRLGCLPREHGLCLIQQEAQEKSINLTAEESQQLFEGVSGIPAAIIYVIGQIAAGYSLEDALSQIKEPDGDVARFCFAGSVIPLRGTPPHYLLMALSLGVKPITRETAASVAFEQADPILTSQGLAKLQQLSLVYHQQGRYSLLELTREYAASELAANRELAQQLQQRWVNWYIRFSEVYGGTNWKEWHLGYSYLEIEWENLRSVLEWCMSQGIYGDARTIWQQIKGYIHVRGYWDERLEWTAWLIETAKQAGDWKFTVEVMCDRAITLIRMRHENQLTEAEILLQEAWNLRQHQSIALQLEIATNMVILSIYQQKWQQAGEWLTEEEKLLTQTSLSELERQQQQVHILYYQGQISFKTGNYQQAQSFFLQALESATTAGWLRATTAIQNWLADIALELGNLKQARQLLEISFPMAERHKDKLSIAYHKATFAKLEKRSGNLPQAKRLAKEAAEGFESLKMVVEAKEMRSLLS
>NC_019751.1|WP_015196014.1|303797_303959_+|hypothetical-protein
MSTPAAGIANHEIVETEEGFILPFLAPIYLSLRRVSFYAFSVKWFFLEKYPIG
>NC_019751.1|WP_015196013.1|303003_303693_-|hypothetical-protein
MGKSFSSLDEVAVKAQKAVIKAENESLSDEDRQQALLEKQIALTKLMTLLMERIKVELPKPGNVGLSEYIYEETLQNIYLYICKNIGKYNSDYSVMAWVKFLLKKRKNNVFNWLNWDGKVSYIDKGLNKDGDEYERNPLESYQPPSLNPLPSEKLIEFIKEDPEGLLASKLFKKNPQASFQAILLKKNEECKTWEEITQELNLGKTHGPIYSFYSRCCDEFSPYFKKYL
>NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1
MSTIYITEPDASFKLQNKYLKLLQQDKQRFFIRISNISQFAIFGNIKLPKDVMQIVRLNQIPAIYFTHTGEYVGRLENPSTVQAKYLNYQRQRLHDREFNRATAESIVWAKLHNQQTFLQNWTRYCTDYTTQRASDYLTLLMDNLSLAPCVEELHQYIEEADKVYYCAVASILSLYSSNPHTTAKQINRFLNLGNQLLHQYIYNHLKTAGLHPDYSILHRDTHHELPLAWDFSAEFRAPIVDDLVLNFVRNLAKNNGNGNGNGKKPYTHLQRFLQHWEGKLKTFVLHPSAGEVSYRQCIDLQVKEYIASLLGDVEYYRPLALKFHPEQTNFINMLETQKPILTLVK
>NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2
MFYLVCYDIVSDTRRNKVSKLLESYGLRVQKSVFECVLDEKQYESISKLLMRLLNRREDQVRFYPMSAHNRCKVAVVGTQPEFSVDDAAFIV
>NC_019751.1|WP_015196024.1|319267_319537_+|hypothetical-protein
MQIQCVRFCLIFSPKAEKQLDDLPNKDRKQYDKAFKCFIQNSPAYRSLRTHRYCSKDGDIWSSSASMAKRFYWRYLEGDIIEITHIDSH
>NC_019751.1|WP_015196025.1|319633_319933_+|hypothetical-protein
MRKPKSLGERELHLIRVYSNWNFGMTPIEFYTKWEVSYEQIALICDRSDSTVRRWFKQGDNRRYPNRNDLLNLALIDFLLEHFEEIPEHLRRLLCAENF
>NC_019751.1|WP_015196027.1|320450_320843_+|hypothetical-protein
MKTTRFLTFLGTTSALLMGLSLIATTSQPAKADWWDVGKQIIEDNLNGIRGNTVGRIYDQTFIAELSSEEVGQYKQRWGGNYSAKISDWCNDTVYQAGWRNLAGNQIPFVNTTWREENGKVNCYVRHAAQ
>NC_019751.1|WP_015196028.1|321419_321713_+|hypothetical-protein
MNKSINRFLLVGGLITVSSVTVATLPINPPAQAGWAPWVQVYVTDYSEGNGRDQGENVRVCQNKAKESGRPDRIKRWWFNSTFRDGKCWTRVPIWEG
>NC_019751.1|WP_144051089.1|322012_322243_+|hypothetical-protein
MLKRGVCAVIGVNTGECASERQNSPSPNYSSPNYPQYPEQPLNNSNQADEYPQYMPPNPEVPYGYPQYTSPNPEEQ
>NC_019751.1|WP_085953333.1|322570_323808_-|ISAzo13-family-transposase
MVLTDSLKKLFIETASQLKGAEKRRFMASTVQSLGLGGQRLAQSELGWNRDTIRKGTRELKSGITCVDNMSGKGRYKAEEHLPNLLEDIKKIVDFYSQTDPSFKSQRLYTRLSAAEVRKQLIEKSGYSDEKLHTSETIRVKLNNLGYKLRRVKKVQPQKKFPQTDAIFEQLDVVNKDADEDKSVLRLSMDGKACVKIGSFDRGGKSRDGVKASDHDYNPKTTVTPYGIFLPELDELFLYFTESKVTSDFIVDILEDFWSCEKHRFSEVKTLLLNQDNGPQNSSRRTQFMKRIVEFAHKHQVNIRLAYYPPYHSKYNPIERTWAVLENHWNGSILDELETALNFASTMKWNGKHPVVKLVHETYENGVKLTKKAMAQIEKQIERLTDSNHEVFPNLGNWFIDICCSKTNVISF
>NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein
MSALNICHFLIGVPGSGKSTFAAALAKLGNNVIISTDEIRTTLYGDAAIQGNWNEIENQALLLIQQAQTSKKSVIYDATNFKRAFRMDFLMKIKEDGETLPLRWIAWYLKTPIETCIKWNQNRNRQVPQPIIETMSKLLANFPPLIAEGFATIEEIDVTKFPTDTAAFTAQIEKRINSLKRRITNRNNRTQHDGIIFHRYSRLLDFDRLMHLISLVIKYPGIGNLHTTNPKLLENILGEIPETTSNIDEITKIMAKLHGGIYGNPSEIIADLQWLEENGVIAGNKEQENNSLSLPSPLSFHCPHPTHSYSDTEPFQRLIGTISFILHNPFLPNIGDGNLPTLAQALQQAGITCGDNLDTLRKDIEKILKPYQILPEFAMRNGYFAGTGILSQAELIRVFETLRSQAQSLDDPLALELYETFKQRMLQTKLIDTDKKVYPVRAIVNRSIVDPRYLHSTALVNNLPKLEAAISNGEVLELNRFSGSGGYDYDPKSFFLAYPLQIVFSNLAWYLGFESVGGNEPGLLRFERLDRLFLGNQQNKTRYRSEQEKSLQKLQALLKGSAGLFLGNSEVEQSKFLSQDQKVHITACMTVELWFNNDVYKFITEGTKRFAKIKMSPPVSSTKNNLPKSIFSLKATKDKQFPHRFQVILPKWSLHDFDLWRWIVGFGGNVKVIEPIELVEKVKGIGSGIVQVYDTKK
>NC_019751.1|WP_041738925.1|329011_329272_-|hypothetical-protein
MYLNFWRDRISLLYYISESDRTCKYLSSGTPRVGVSYHDISRKISKSTLFLANRSGVLQVIGFWELKPLSVKAFSYFSLKGGLPNF

Crispr_ID: NC_019751_2

• CRISPR_ID: NC_019751_2
• CRISPR_location: 324319-325428
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 15 spacers
• Cas_protein_info: cas2,cas1,WYL,cas10,cmr4gr7,cmr5gr11,csx1

Consensus repeat of NC_019751_2

Consensus_repeat	Method
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	PILER-CR
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	CRISPRCasFinder
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	CRT

spacers of NC_019751_2

>2.1|324354|39|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TAGGAAGTTTTCGCTTGGGTATTGCTTAATTTAGCAGAG
>2.2|324428|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TATTTAAGGCTATATCGCTTCTAAATTGAGAGACA
>2.3|324498|44|NC_019751|PILER-CR,CRISPRCasFinder,CRT
AAGACAGAGATATGTCCTCAAAGAGAAATGAGTTTGTCTCAATT
>2.4|324577|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TTTTATCTGCTTTTGTAAACTCTCCCCAATGCAAAG
>2.5|324648|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
ACTGGTTTGCCGCTTGAGTGGGCATAGTCAAAAAAT
>2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
AGTTTGAGTCTCGGTCTCGGTCTCGGTCTCGGTCTC
>2.7|324790|39|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TTTACACGATTCTGGAACGTTACTAACATCCCATCAGGA
>2.8|324864|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TCGTTGAGTTGGTACACCAGCTGACTCTCAATTTG
>2.9|324934|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
ATTAGGGTCTCTGTAGATCTTAAATTCCTCAGAGTA
>2.10|325005|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
GAATGAAAAGATTTTTACATCTTTTGCTGATAAAA
>2.11|325075|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
GTGTAAGTCACGGAATTTTCGGTTGAACTAACTAAT
>2.12|325146|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CTTTGATGTAAGAAAACTCATCACTAGCAAAAAAA
>2.13|325216|38|NC_019751|PILER-CR,CRISPRCasFinder,CRT
GGGGCTCTTAGCTCTGCCCGTAATTCGTCGCGGGACTT
>2.14|325289|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
GTGTCGCTGCTTTCAACTTCTGCTGCACAAACTACG
>2.15|325360|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CTGAATTTTGTTATTCTAACCTCCACTCCACATG

CRISPR arrays and Neighbor proteins around NC_019751_2

CRISPR arrays

The CRISPR arrays of NC_019751_2

>merge|NC_019751|2|324319-325428|PILER-CR,CRISPRCasFinder,CRT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACTAGGAAGTTTTCGCTTGGGTATTGCTTAATTTAGCAGAGCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACTATTTAAGGCTATATCGCTTCTAAATTGAGAGACACTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACAAGACAGAGATATGTCCTCAAAGAGAAATGAGTTTGTCTCAATTCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACTTTTATCTGCTTTTGTAAACTCTCCCCAATGCAAAGCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACACTGGTTTGCCGCTTGAGTGGGCATAGTCAAAAAATCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACAGTTTGAGTCTCGGTCTCGGTCTCGGTCTCGGTCTCCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACTTTACACGATTCTGGAACGTTACTAACATCCCATCAGGACTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACTCGTTGAGTTGGTACACCAGCTGACTCTCAATTTGCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACATTAGGGTCTCTGTAGATCTTAAATTCCTCAGAGTACTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACGAATGAAAAGATTTTTACATCTTTTGCTGATAAAACTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACGTGTAAGTCACGGAATTTTCGGTTGAACTAACTAATCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACCTTTGATGTAAGAAAACTCATCACTAGCAAAAAAACTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACGGGGCTCTTAGCTCTGCCCGTAATTCGTCGCGGGACTTCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACGTGTCGCTGCTTTCAACTTCTGCTGCACAAACTACGCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACCTGAATTTTGTTATTCTAACCTCCACTCCACATGCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC

>NC_019751|2|2|324319-325428|PILER-CR
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TAGGAAGTTTTCGCTTGGGTATTGCTTAATTTAGCAGAG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TATTTAAGGCTATATCGCTTCTAAATTGAGAGACA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	AAGACAGAGATATGTCCTCAAAGAGAAATGAGTTTGTCTCAATT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TTTTATCTGCTTTTGTAAACTCTCCCCAATGCAAAG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	ACTGGTTTGCCGCTTGAGTGGGCATAGTCAAAAAAT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	AGTTTGAGTCTCGGTCTCGGTCTCGGTCTCGGTCTC
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TTTACACGATTCTGGAACGTTACTAACATCCCATCAGGA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TCGTTGAGTTGGTACACCAGCTGACTCTCAATTTG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	ATTAGGGTCTCTGTAGATCTTAAATTCCTCAGAGTA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GAATGAAAAGATTTTTACATCTTTTGCTGATAAAA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GTGTAAGTCACGGAATTTTCGGTTGAACTAACTAAT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	CTTTGATGTAAGAAAACTCATCACTAGCAAAAAAA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GGGGCTCTTAGCTCTGCCCGTAATTCGTCGCGGGACTT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GTGTCGCTGCTTTCAACTTCTGCTGCACAAACTACG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	CTGAATTTTGTTATTCTAACCTCCACTCCACATG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC

>NC_019751|2|2|324319-325428|CRISPRCasFinder
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TAGGAAGTTTTCGCTTGGGTATTGCTTAATTTAGCAGAG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TATTTAAGGCTATATCGCTTCTAAATTGAGAGACA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	AAGACAGAGATATGTCCTCAAAGAGAAATGAGTTTGTCTCAATT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TTTTATCTGCTTTTGTAAACTCTCCCCAATGCAAAG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	ACTGGTTTGCCGCTTGAGTGGGCATAGTCAAAAAAT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	AGTTTGAGTCTCGGTCTCGGTCTCGGTCTCGGTCTC
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TTTACACGATTCTGGAACGTTACTAACATCCCATCAGGA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TCGTTGAGTTGGTACACCAGCTGACTCTCAATTTG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	ATTAGGGTCTCTGTAGATCTTAAATTCCTCAGAGTA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GAATGAAAAGATTTTTACATCTTTTGCTGATAAAA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GTGTAAGTCACGGAATTTTCGGTTGAACTAACTAAT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	CTTTGATGTAAGAAAACTCATCACTAGCAAAAAAA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GGGGCTCTTAGCTCTGCCCGTAATTCGTCGCGGGACTT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GTGTCGCTGCTTTCAACTTCTGCTGCACAAACTACG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	CTGAATTTTGTTATTCTAACCTCCACTCCACATG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC

>NC_019751|2|2|324319-325428|CRT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TAGGAAGTTTTCGCTTGGGTATTGCTTAATTTAGCAGAG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TATTTAAGGCTATATCGCTTCTAAATTGAGAGACA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	AAGACAGAGATATGTCCTCAAAGAGAAATGAGTTTGTCTCAATT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TTTTATCTGCTTTTGTAAACTCTCCCCAATGCAAAG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	ACTGGTTTGCCGCTTGAGTGGGCATAGTCAAAAAAT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	AGTTTGAGTCTCGGTCTCGGTCTCGGTCTCGGTCTC
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TTTACACGATTCTGGAACGTTACTAACATCCCATCAGGA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	TCGTTGAGTTGGTACACCAGCTGACTCTCAATTTG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	ATTAGGGTCTCTGTAGATCTTAAATTCCTCAGAGTA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GAATGAAAAGATTTTTACATCTTTTGCTGATAAAA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GTGTAAGTCACGGAATTTTCGGTTGAACTAACTAAT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	CTTTGATGTAAGAAAACTCATCACTAGCAAAAAAA
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GGGGCTCTTAGCTCTGCCCGTAATTCGTCGCGGGACTT
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	GTGTCGCTGCTTTCAACTTCTGCTGCACAAACTACG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC	CTGAATTTTGTTATTCTAACCTCCACTCCACATG
CTTTAGACTTCTTCGGAAGTTGAATTAATGGAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_158333119.1|316385_316526_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196037.1|338872_339235_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|376633
NC_019751.1|WP_015196032.1|332141_332951_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl|CDD|224255
NC_019751.1|WP_015196034.1|333427_335047_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196024.1|319267_319537_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_144051088.1|337174_338395_+|ISL3-family-transposase	unknown	unknown	gnl|CDD|225995
NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl|CDD|379324
NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_019751.1|WP_041738925.1|329011_329272_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196021.1|314349_316356_+|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|376633
NC_019751.1|WP_015196036.1|338483_338750_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196027.1|320450_320843_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196035.1|335224_336832_+|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	unknown
NC_019751.1|WP_015196033.1|333002_333431_+|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	unknown
NC_019751.1|WP_015196031.1|329577_331143_+|hypothetical-protein	cas10	cd09679_cas10_CAS-III	gnl|CDD|187810
NC_019751.1|WP_144051089.1|322012_322243_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196025.1|319633_319933_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_085953333.1|322570_323808_-|ISAzo13-family-transposase	unknown	unknown	gnl|CDD|369439
NC_019751.1|WP_015196028.1|321419_321713_+|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_019751.1|WP_015196035.1|335224_336832_+|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	1.9e-196	648.6	8.6
NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	2.5e-49	162.7	1.6
NC_019751.1|WP_015196032.1|332141_332951_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	3.3e-31	103.6	0.0
NC_019751.1|WP_015196031.1|329577_331143_+|hypothetical-protein	cas10	cd09679_cas10_CAS-III	7.3e-20	65.9	0.2
NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	1.8e-20	68.4	0.0
NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.5e-28	93.6	0.6
NC_019751.1|WP_015196033.1|333002_333431_+|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	2.7e-64	209.5	3.5
NC_019751.1|WP_015196021.1|314349_316356_+|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	2.9e-93	307.0	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1	gnl|CDD|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	9.09473e-58
NC_019751.1|WP_015196032.1|332141_332951_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl|CDD|224255	COG1336, COG1336, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	6.05803e-27
NC_019751.1|WP_144051088.1|337174_338395_+|ISL3-family-transposase	gnl|CDD|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.08988e-78
NC_019751.1|WP_015196031.1|329577_331143_+|hypothetical-protein	gnl|CDD|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	7.64435e-14
NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein	gnl|CDD|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	2.18109e-20
NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.11877e-27
NC_019751.1|WP_085953333.1|322570_323808_-|ISAzo13-family-transposase	gnl|CDD|369439	pfam07592, DDE_Tnp_ISAZ013, Rhodopirellula transposase DDE domain. These transposases are found in the planctomycete Rhodopirellula baltica, the cyanobacterium Nostoc, and the Gram-positive bacterium Streptomyces.	6.49222e-78
NC_019751.1|WP_015196021.1|314349_316356_+|CRISPR-associated-endonuclease-Cas1	gnl|CDD|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	2.7683e-111

Protein sequences

>NC_019751.1|WP_085953333.1|322570_323808_-|ISAzo13-family-transposase
MVLTDSLKKLFIETASQLKGAEKRRFMASTVQSLGLGGQRLAQSELGWNRDTIRKGTRELKSGITCVDNMSGKGRYKAEEHLPNLLEDIKKIVDFYSQTDPSFKSQRLYTRLSAAEVRKQLIEKSGYSDEKLHTSETIRVKLNNLGYKLRRVKKVQPQKKFPQTDAIFEQLDVVNKDADEDKSVLRLSMDGKACVKIGSFDRGGKSRDGVKASDHDYNPKTTVTPYGIFLPELDELFLYFTESKVTSDFIVDILEDFWSCEKHRFSEVKTLLLNQDNGPQNSSRRTQFMKRIVEFAHKHQVNIRLAYYPPYHSKYNPIERTWAVLENHWNGSILDELETALNFASTMKWNGKHPVVKLVHETYENGVKLTKKAMAQIEKQIERLTDSNHEVFPNLGNWFIDICCSKTNVISF
>NC_019751.1|WP_144051089.1|322012_322243_+|hypothetical-protein
MLKRGVCAVIGVNTGECASERQNSPSPNYSSPNYPQYPEQPLNNSNQADEYPQYMPPNPEVPYGYPQYTSPNPEEQ
>NC_019751.1|WP_015196028.1|321419_321713_+|hypothetical-protein
MNKSINRFLLVGGLITVSSVTVATLPINPPAQAGWAPWVQVYVTDYSEGNGRDQGENVRVCQNKAKESGRPDRIKRWWFNSTFRDGKCWTRVPIWEG
>NC_019751.1|WP_015196027.1|320450_320843_+|hypothetical-protein
MKTTRFLTFLGTTSALLMGLSLIATTSQPAKADWWDVGKQIIEDNLNGIRGNTVGRIYDQTFIAELSSEEVGQYKQRWGGNYSAKISDWCNDTVYQAGWRNLAGNQIPFVNTTWREENGKVNCYVRHAAQ
>NC_019751.1|WP_015196025.1|319633_319933_+|hypothetical-protein
MRKPKSLGERELHLIRVYSNWNFGMTPIEFYTKWEVSYEQIALICDRSDSTVRRWFKQGDNRRYPNRNDLLNLALIDFLLEHFEEIPEHLRRLLCAENF
>NC_019751.1|WP_015196024.1|319267_319537_+|hypothetical-protein
MQIQCVRFCLIFSPKAEKQLDDLPNKDRKQYDKAFKCFIQNSPAYRSLRTHRYCSKDGDIWSSSASMAKRFYWRYLEGDIIEITHIDSH
>NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2
MFYLVCYDIVSDTRRNKVSKLLESYGLRVQKSVFECVLDEKQYESISKLLMRLLNRREDQVRFYPMSAHNRCKVAVVGTQPEFSVDDAAFIV
>NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1
MSTIYITEPDASFKLQNKYLKLLQQDKQRFFIRISNISQFAIFGNIKLPKDVMQIVRLNQIPAIYFTHTGEYVGRLENPSTVQAKYLNYQRQRLHDREFNRATAESIVWAKLHNQQTFLQNWTRYCTDYTTQRASDYLTLLMDNLSLAPCVEELHQYIEEADKVYYCAVASILSLYSSNPHTTAKQINRFLNLGNQLLHQYIYNHLKTAGLHPDYSILHRDTHHELPLAWDFSAEFRAPIVDDLVLNFVRNLAKNNGNGNGNGKKPYTHLQRFLQHWEGKLKTFVLHPSAGEVSYRQCIDLQVKEYIASLLGDVEYYRPLALKFHPEQTNFINMLETQKPILTLVK
>NC_019751.1|WP_158333119.1|316385_316526_+|hypothetical-protein
MAETLILSFYPTNRYPGKGLMLLEYGLITKNYQLFRKNFTPHKKWR
>NC_019751.1|WP_015196021.1|314349_316356_+|CRISPR-associated-endonuclease-Cas1
MFTLEHLNYAWLQVRAGSKSAGVDGISIGFFESMATEQLRNLVSQLQYGTYTASPAKGFYVPKKNGGKRLIGIPTVRDRIIQRLLLDELYFPLEDTFVDCSYAYRPGRNIQQAVQHLYRYYQYQPKWIIKADIVEFFDNICLALLLNALEKLRLEPNILQLIEQQIKSGIIINGQYQNAGKGLLQGGTLSGALANLYLTDFDQKCLNQGINLVRYGDDFVIACSNFAEANRVLDKITGWLGGVYLTLKAEKTEIFSPDDEFTFLGYRFAKGEVFAPPPPEPTQQGEWVINDSGTPYFRRKPKPEKPVSRPPKACSIDKPVNFPRAAISHYWQDFMSTLYVTDQGAYLSMKNQQFQVFYQGELKIKIPVVRVSSIVMFGCCNVSHGAVSMALIRRIPIMYLSQKGRYFGHTAVQGNAKVEYLMKQVICCQNPVFTRQQAETIVAAKLHNSRILLMRLNRRRETEIATQAIDFIEILIDSLPKAESMDALRGYEGKAATIYFQALGSLFTGFFAFDKRTKRPPTDPINSLMSLGYTLLSQQVFSFVQSVGLHTHFGNLHVPRDNHPALVSDLMEEFRAQIVDSFVSYIVNKKILTPEDFTSPDERGGVYLQASALKKYLKHWEEKLQSETTHPNTGYKVAYRRCIELQVREYVACLVGEVEVYRPMTWKM
>NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein
MSALNICHFLIGVPGSGKSTFAAALAKLGNNVIISTDEIRTTLYGDAAIQGNWNEIENQALLLIQQAQTSKKSVIYDATNFKRAFRMDFLMKIKEDGETLPLRWIAWYLKTPIETCIKWNQNRNRQVPQPIIETMSKLLANFPPLIAEGFATIEEIDVTKFPTDTAAFTAQIEKRINSLKRRITNRNNRTQHDGIIFHRYSRLLDFDRLMHLISLVIKYPGIGNLHTTNPKLLENILGEIPETTSNIDEITKIMAKLHGGIYGNPSEIIADLQWLEENGVIAGNKEQENNSLSLPSPLSFHCPHPTHSYSDTEPFQRLIGTISFILHNPFLPNIGDGNLPTLAQALQQAGITCGDNLDTLRKDIEKILKPYQILPEFAMRNGYFAGTGILSQAELIRVFETLRSQAQSLDDPLALELYETFKQRMLQTKLIDTDKKVYPVRAIVNRSIVDPRYLHSTALVNNLPKLEAAISNGEVLELNRFSGSGGYDYDPKSFFLAYPLQIVFSNLAWYLGFESVGGNEPGLLRFERLDRLFLGNQQNKTRYRSEQEKSLQKLQALLKGSAGLFLGNSEVEQSKFLSQDQKVHITACMTVELWFNNDVYKFITEGTKRFAKIKMSPPVSSTKNNLPKSIFSLKATKDKQFPHRFQVILPKWSLHDFDLWRWIVGFGGNVKVIEPIELVEKVKGIGSGIVQVYDTKK
>NC_019751.1|WP_041738925.1|329011_329272_-|hypothetical-protein
MYLNFWRDRISLLYYISESDRTCKYLSSGTPRVGVSYHDISRKISKSTLFLANRSGVLQVIGFWELKPLSVKAFSYFSLKGGLPNF
>NC_019751.1|WP_015196031.1|329577_331143_+|hypothetical-protein
MPKYTAITFAPVQGFIEKSRKLRDLYGSSQILSYLSQELLNEAGKTTEVVSPAIIKMQKGMPNRILLKGDFTEKQARDTLSSAWKRILFECRSWIGTKLPEKSYGTYHWEREWQNWGNYAWEVFCGSGDTISAAMEDLETKKLSRDWIGVNWIGESSSLTGTDAIAFPGLGAESRNPNNRKWSAEKEEIKTFYRRLACVLEGISLDKEPEGKYIALEEKLSIPELVKRLVTHEDIATSLGISPLGNSFSDIYRRPEKITETEKGRCTGWFMGDGDKVGDYLKDLAQKSDAEVKLFSQAMREWGRDFARDFPKEFGRVVYAGGDDFLGAIYSDKDKPKIEPEQVYQWLLELPNKWREHKQPINVSVGFIWAASSVPQRDILQHCREAEKVAKSLGRNRVTIRILFNSGQYVEWTCPWNYLNILDKYKDLDGNSNWSHIYTDLAQLEARNAFNIDKRTFNRKFALDFFDIYFPGEGEKLSKDNNLLKNIVGYTDDDEEYERVEKTIDWMRSLIKVGFQLCSNT
>NC_019751.1|WP_015196032.1|332141_332951_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MYKKAFGIIETLAPLHVGATAGEESGNLNLIFRDQFTQTGIIPGSSLRGRFRAEMRSQVDEKEVSYWYGEGASSEQSEINNESMVKFEHASIVWLPVFCPGQPIVWVSSPRLLERYKRIAQIDAEIPSLYVASSNIRARESQGKKTIFFNLGFLNIIRSENLSKWFPNGKELPAVIVDDSDIAMIHDMALYRQSRVRLKDNEKVVDGGGFFNTEALPEGTILVFPIAIRDDKSNKKWQPFPNDITDEIYLGGLESIGFGHCQLKIVNRN
>NC_019751.1|WP_015196033.1|333002_333431_+|hypothetical-protein
MNWQPYNLDQEAQRLVLAFRNKEGVIGQSHKMRVTVAYGLERFWGEHLRLLGKNDAKEREKGKYWQSVWKEFVRIMKRTGVELPSDEISDRNTEQIEEVAKKLWSLSLDDQKICLSVLTQFCDSLVWWTQRYKKAGDREEEV
>NC_019751.1|WP_015196034.1|333427_335047_+|hypothetical-protein
MTNYREIPLMFQAQIKGRGQIQYIAQPEKAYRWVDEWEEGVGNDVSNFSNRVSTKEYKITWRFISNSGQDDDVIRPVIASGGFPYYPGASMKGAFLRSCTPEQAMHYCGGIASKADSTTKPGILRFHGGYPKDATWKDKELVDVVHPQADWQLKDSSSHSAFIQISLHEPTLVFGISSNIKIESSEWDTIWSIWEKALERGIGSRVSAGYGQPVKHPETKLLTVGLTGQGLASQLINKTGEFRPNMFKAALRGHTLRLFAGITDENSAEALTRELWGGFAGKDGAVVGDLGIVFNPLELEMDGYRYRGNSIPTYELNNGILHILSMRSVSEEYKTELRSLAIKLIQFSLLLGGFGKSWRRIDHRIFFPDYLKNNQKPMIGCHWEFHQGAEKLYIPTNRLENISKFFTTLDEKIHQWIIANNKKTSNNLSQWREVWHPQKVQVWARVAEDEDDSSAVHWFHGEYKEGGTIKGSTLTGQIGQIGRIWHRMYPRYSKLKDGTMRRMGDEYIELLTIFPDTSNTTTQFIDFLGKSYFKRIYPS
>NC_019751.1|WP_015196035.1|335224_336832_+|hypothetical-protein
MAIWIITTGNSDVRIKKENNWNTIFHTIRDNLECTDFASPIPINPNAIEEGYTLPARVLGVAYSQIIEQEPKYFDELEFPLIETFCQKLKSEKKLEKKSHKLEQIFVLTTDQNNLFPNKWDRINEKCPYWQDTIELQTLLEKYLKTQFDIPIEFISLCPNSDEGLDYWDATLKLVETEFSQKFAKLQDKIVYVSHQAGTPAISAAVQFASLGIFGKVEFLVSNQYYDASYNHQAKAKIIDSSEYWRGLQIQKAKPLIRNGFPSTALKLLDGIDRIDKNIILQLEQMVDFFNLKSQSQNTNPDSIKEDFGIPNATQRIVDGLDLIGFFFKQNNYLPGISLLAAAQETFLKVAIKSEIQKNTANYCGIPVAELVKWTTKGLISPNNDELRNILKLPNSQNIDKVRNDIFDLLKFPYSKHNDRFYLYSIKQDLEFSRTGMLEWLLILAPNFREWAHLRQSNLRNQVIHNLRGIEEEEVIAYLLGLRDYQPIPNNITTAMDAYIQKVKQPFMQAIVLLKLPCEKGKLQERLNAIADSLI
>NC_019751.1|WP_144051088.1|337174_338395_+|ISL3-family-transposase
MKVLTELLDLKDIKVTSQRIYNGIGIILQTESTKSYSICPHCGTKSEKLHQNHSHIIKDLPFSEKPVFLEVNRRQFKCYQCQKPFSEELYYAKKKRTYTNRLAQKIIQDVLESDIHSVASKGIVTTEEIERMLKDASEELCDSKPSNLKRLGIDEIALVKGKGDYCAVLVDLDASKLLAILNGRTQDKIKEALSGWGLEVLQQIEEVSIDLWQGYKNLVMELMPNAQVVADRFHVMTQINKELDTQRKRERRSIEEQIKETKSESEKAEYEIILAGLKNSKYSLLKNEDNLTDEQVVKLREVKRVSPVLKEMHDFKEKIRKIFNLTDHWYTGVFKLGMWLSKAKKYFPRSNNTIIRWFDEIIAYFDNGTTSGTVEGINNKLKLIKRSGYGFRNFQNFKIRCLLNWT
>NC_019751.1|WP_015196036.1|338483_338750_+|hypothetical-protein
MNIINITFTHPFAKAPKHVFGQQVTIKSNCDRKKWAKGQITGLRLDYNSPNTWNYTVVFDYPQGFCEEFTEEDLAAVDELVCSQLLFK
>NC_019751.1|WP_015196037.1|338872_339235_+|hypothetical-protein
MKTPQQIEAALNQFTGSTTLYKHWLGLKYTDGIKYLAEETSCYWLLDAIFSHQTKTFLSNQNLREFQIWYLRVENNSGVLICEWDTNQEVLRQEIEYTDFSLSHIKLYLIETVLMLPSEY

Crispr_ID: NC_019751_3

• CRISPR_ID: NC_019751_3
• CRISPR_location: 328043-328873
• CRISPR_type: TypeIII
• Repeat_type: NA
• Spacer_info: 11 spacers
• Cas_protein_info: WYL,cas2,cas1,cas10,cmr4gr7,cmr5gr11,csx1

Consensus repeat of NC_019751_3

Consensus_repeat	Method
GTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	CRISPRCasFinder
GTTTCCATTAATTCAGCTTCAANAGAAGCTTTGAAAC	CRT
GTTTCAAAGCTTCTTTTGAAGCTGAATTAATGGAAAC	PILER-CR

spacers of NC_019751_3

>3.1|328080|37|NC_019751|CRISPRCasFinder,CRT
AAGCGGCTGAATTTAAACCCGAAACCATCCAAGAATA
>3.2|328154|33|NC_019751|CRISPRCasFinder,CRT
GATTACAAACCTTGGTGTTTCTACCCAAATTGC
>3.3|328224|35|NC_019751|CRISPRCasFinder,CRT
ATAATCAACCTAGCGGGATAAATCTTCCTTATTTA
>3.4|328296|35|NC_019751|CRISPRCasFinder,CRT
ATTGAATTCATCCACCTCATCATCTGTATCGAAGG
>3.5|328368|34|NC_019751|CRISPRCasFinder,CRT
CAAAATCAACTGGCTAGCAACGAAGCTCAGATGC
>3.6|328439|35|NC_019751|CRISPRCasFinder,CRT
TTCAGAGTTGGAAAATTTATTTGCCGTTTGTACTT
>3.7|328511|36|NC_019751|CRISPRCasFinder,CRT
TTTCTTGCCACTTAAGATGCTGATAAGTTGTGTTGT
>3.8|328584|37|NC_019751|CRISPRCasFinder,CRT
CAATATCACCCTTGGAAACTGGATCATCTACATAAAA
>3.9|328658|33|NC_019751|CRISPRCasFinder,CRT
TTATCCATGTAATGTAATAATAGGTTGCTTTGA
>3.10|328728|35|NC_019751|CRISPRCasFinder,CRT
CTTAAGGTAACGGCTAAGGATTATAAAGGAAATGA
>3.11|328800|37|NC_019751|CRISPRCasFinder,CRT
CAACAAAGCAGTTGATTATAAATTGAGCTTACCAAGG
>3.12|328081|37|NC_019751|PILER-CR
AAGCGGCTGAATTTAAACCCGAAACCATCCAAGAATA
>3.13|328155|33|NC_019751|PILER-CR
GATTACAAACCTTGGTGTTTCTACCCAAATTGC
>3.14|328225|35|NC_019751|PILER-CR
ATAATCAACCTAGCGGGATAAATCTTCCTTATTTA
>3.15|328297|35|NC_019751|PILER-CR
ATTGAATTCATCCACCTCATCATCTGTATCGAAGG
>3.16|328369|34|NC_019751|PILER-CR
CAAAATCAACTGGCTAGCAACGAAGCTCAGATGC
>3.17|328440|35|NC_019751|PILER-CR
TTCAGAGTTGGAAAATTTATTTGCCGTTTGTACTT
>3.18|328512|36|NC_019751|PILER-CR
TTTCTTGCCACTTAAGATGCTGATAAGTTGTGTTGT
>3.19|328585|37|NC_019751|PILER-CR
CAATATCACCCTTGGAAACTGGATCATCTACATAAAA
>3.20|328659|33|NC_019751|PILER-CR
TTATCCATGTAATGTAATAATAGGTTGCTTTGA
>3.21|328729|35|NC_019751|PILER-CR
CTTAAGGTAACGGCTAAGGATTATAAAGGAAATGA
>3.22|328801|37|NC_019751|PILER-CR
CAACAAAGCAGTTGATTATAAATTGAGCTTACCAAGG

CRISPR arrays and Neighbor proteins around NC_019751_3

CRISPR arrays

The CRISPR arrays of NC_019751_3

>merge|NC_019751|3|328043-328873|CRISPRCasFinder,CRT,PILER-CR
ATTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACAAGCGGCTGAATTTAAACCCGAAACCATCCAAGAATAGTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACGATTACAAACCTTGGTGTTTCTACCCAAATTGCGTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACATAATCAACCTAGCGGGATAAATCTTCCTTATTTAGTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACATTGAATTCATCCACCTCATCATCTGTATCGAAGGGTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACCAAAATCAACTGGCTAGCAACGAAGCTCAGATGCGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACTTCAGAGTTGGAAAATTTATTTGCCGTTTGTACTTGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACTTTCTTGCCACTTAAGATGCTGATAAGTTGTGTTGTGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACCAATATCACCCTTGGAAACTGGATCATCTACATAAAAGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACTTATCCATGTAATGTAATAATAGGTTGCTTTGAGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACCTTAAGGTAACGGCTAAGGATTATAAAGGAAATGAGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACCAACAAAGCAGTTGATTATAAATTGAGCTTACCAAGGGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC

>NC_019751|3|3|328043-328873|CRISPRCasFinder
ATTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	AAGCGGCTGAATTTAAACCCGAAACCATCCAAGAATA
GTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	GATTACAAACCTTGGTGTTTCTACCCAAATTGC
GTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	ATAATCAACCTAGCGGGATAAATCTTCCTTATTTA
GTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	ATTGAATTCATCCACCTCATCATCTGTATCGAAGG
GTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	CAAAATCAACTGGCTAGCAACGAAGCTCAGATGC
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	TTCAGAGTTGGAAAATTTATTTGCCGTTTGTACTT
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	TTTCTTGCCACTTAAGATGCTGATAAGTTGTGTTGT
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	CAATATCACCCTTGGAAACTGGATCATCTACATAAAA
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	TTATCCATGTAATGTAATAATAGGTTGCTTTGA
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	CTTAAGGTAACGGCTAAGGATTATAAAGGAAATGA
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	CAACAAAGCAGTTGATTATAAATTGAGCTTACCAAGG
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC

>NC_019751|3|3|328043-328873|CRT
ATTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	AAGCGGCTGAATTTAAACCCGAAACCATCCAAGAATA
GTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	GATTACAAACCTTGGTGTTTCTACCCAAATTGC
GTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	ATAATCAACCTAGCGGGATAAATCTTCCTTATTTA
GTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	ATTGAATTCATCCACCTCATCATCTGTATCGAAGG
GTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAAC	CAAAATCAACTGGCTAGCAACGAAGCTCAGATGC
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	TTCAGAGTTGGAAAATTTATTTGCCGTTTGTACTT
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	TTTCTTGCCACTTAAGATGCTGATAAGTTGTGTTGT
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	CAATATCACCCTTGGAAACTGGATCATCTACATAAAA
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	TTATCCATGTAATGTAATAATAGGTTGCTTTGA
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	CTTAAGGTAACGGCTAAGGATTATAAAGGAAATGA
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC	CAACAAAGCAGTTGATTATAAATTGAGCTTACCAAGG
GTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC

>NC_019751|3|3|328044-328873|PILER-CR
TTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACA	AGCGGCTGAATTTAAACCCGAAACCATCCAAGAATAG
TTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACG	ATTACAAACCTTGGTGTTTCTACCCAAATTGCG
TTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACA	TAATCAACCTAGCGGGATAAATCTTCCTTATTTAG
TTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACA	TTGAATTCATCCACCTCATCATCTGTATCGAAGGG
TTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACC	AAAATCAACTGGCTAGCAACGAAGCTCAGATGCG
TTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACT	TCAGAGTTGGAAAATTTATTTGCCGTTTGTACTTG
TTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACT	TTCTTGCCACTTAAGATGCTGATAAGTTGTGTTGTG
TTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACC	AATATCACCCTTGGAAACTGGATCATCTACATAAAAG
TTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACT	TATCCATGTAATGTAATAATAGGTTGCTTTGAG
TTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACC	TTAAGGTAACGGCTAAGGATTATAAAGGAAATGAG
TTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACC	AACAAAGCAGTTGATTATAAATTGAGCTTACCAAGGG
TTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_158333119.1|316385_316526_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196037.1|338872_339235_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|376633
NC_019751.1|WP_015196032.1|332141_332951_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl|CDD|224255
NC_019751.1|WP_015196034.1|333427_335047_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196024.1|319267_319537_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_144051088.1|337174_338395_+|ISL3-family-transposase	unknown	unknown	gnl|CDD|225995
NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl|CDD|379324
NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_019751.1|WP_041738925.1|329011_329272_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196036.1|338483_338750_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196027.1|320450_320843_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196035.1|335224_336832_+|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	unknown
NC_019751.1|WP_015196033.1|333002_333431_+|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	unknown
NC_019751.1|WP_015196038.1|339270_339516_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196031.1|329577_331143_+|hypothetical-protein	cas10	cd09679_cas10_CAS-III	gnl|CDD|187810
NC_019751.1|WP_144051089.1|322012_322243_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196025.1|319633_319933_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_085953333.1|322570_323808_-|ISAzo13-family-transposase	unknown	unknown	gnl|CDD|369439
NC_019751.1|WP_015196028.1|321419_321713_+|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_019751.1|WP_015196035.1|335224_336832_+|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	1.9e-196	648.6	8.6
NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	2.5e-49	162.7	1.6
NC_019751.1|WP_015196032.1|332141_332951_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	3.3e-31	103.6	0.0
NC_019751.1|WP_015196031.1|329577_331143_+|hypothetical-protein	cas10	cd09679_cas10_CAS-III	7.3e-20	65.9	0.2
NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	1.8e-20	68.4	0.0
NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.5e-28	93.6	0.6
NC_019751.1|WP_015196033.1|333002_333431_+|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	2.7e-64	209.5	3.5

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1	gnl|CDD|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	9.09473e-58
NC_019751.1|WP_015196032.1|332141_332951_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl|CDD|224255	COG1336, COG1336, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	6.05803e-27
NC_019751.1|WP_144051088.1|337174_338395_+|ISL3-family-transposase	gnl|CDD|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.08988e-78
NC_019751.1|WP_015196031.1|329577_331143_+|hypothetical-protein	gnl|CDD|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	7.64435e-14
NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein	gnl|CDD|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	2.18109e-20
NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.11877e-27
NC_019751.1|WP_085953333.1|322570_323808_-|ISAzo13-family-transposase	gnl|CDD|369439	pfam07592, DDE_Tnp_ISAZ013, Rhodopirellula transposase DDE domain. These transposases are found in the planctomycete Rhodopirellula baltica, the cyanobacterium Nostoc, and the Gram-positive bacterium Streptomyces.	6.49222e-78

Protein sequences

>NC_019751.1|WP_015196030.1|325819_327913_-|WYL-domain-containing-protein
MSALNICHFLIGVPGSGKSTFAAALAKLGNNVIISTDEIRTTLYGDAAIQGNWNEIENQALLLIQQAQTSKKSVIYDATNFKRAFRMDFLMKIKEDGETLPLRWIAWYLKTPIETCIKWNQNRNRQVPQPIIETMSKLLANFPPLIAEGFATIEEIDVTKFPTDTAAFTAQIEKRINSLKRRITNRNNRTQHDGIIFHRYSRLLDFDRLMHLISLVIKYPGIGNLHTTNPKLLENILGEIPETTSNIDEITKIMAKLHGGIYGNPSEIIADLQWLEENGVIAGNKEQENNSLSLPSPLSFHCPHPTHSYSDTEPFQRLIGTISFILHNPFLPNIGDGNLPTLAQALQQAGITCGDNLDTLRKDIEKILKPYQILPEFAMRNGYFAGTGILSQAELIRVFETLRSQAQSLDDPLALELYETFKQRMLQTKLIDTDKKVYPVRAIVNRSIVDPRYLHSTALVNNLPKLEAAISNGEVLELNRFSGSGGYDYDPKSFFLAYPLQIVFSNLAWYLGFESVGGNEPGLLRFERLDRLFLGNQQNKTRYRSEQEKSLQKLQALLKGSAGLFLGNSEVEQSKFLSQDQKVHITACMTVELWFNNDVYKFITEGTKRFAKIKMSPPVSSTKNNLPKSIFSLKATKDKQFPHRFQVILPKWSLHDFDLWRWIVGFGGNVKVIEPIELVEKVKGIGSGIVQVYDTKK
>NC_019751.1|WP_085953333.1|322570_323808_-|ISAzo13-family-transposase
MVLTDSLKKLFIETASQLKGAEKRRFMASTVQSLGLGGQRLAQSELGWNRDTIRKGTRELKSGITCVDNMSGKGRYKAEEHLPNLLEDIKKIVDFYSQTDPSFKSQRLYTRLSAAEVRKQLIEKSGYSDEKLHTSETIRVKLNNLGYKLRRVKKVQPQKKFPQTDAIFEQLDVVNKDADEDKSVLRLSMDGKACVKIGSFDRGGKSRDGVKASDHDYNPKTTVTPYGIFLPELDELFLYFTESKVTSDFIVDILEDFWSCEKHRFSEVKTLLLNQDNGPQNSSRRTQFMKRIVEFAHKHQVNIRLAYYPPYHSKYNPIERTWAVLENHWNGSILDELETALNFASTMKWNGKHPVVKLVHETYENGVKLTKKAMAQIEKQIERLTDSNHEVFPNLGNWFIDICCSKTNVISF
>NC_019751.1|WP_144051089.1|322012_322243_+|hypothetical-protein
MLKRGVCAVIGVNTGECASERQNSPSPNYSSPNYPQYPEQPLNNSNQADEYPQYMPPNPEVPYGYPQYTSPNPEEQ
>NC_019751.1|WP_015196028.1|321419_321713_+|hypothetical-protein
MNKSINRFLLVGGLITVSSVTVATLPINPPAQAGWAPWVQVYVTDYSEGNGRDQGENVRVCQNKAKESGRPDRIKRWWFNSTFRDGKCWTRVPIWEG
>NC_019751.1|WP_015196027.1|320450_320843_+|hypothetical-protein
MKTTRFLTFLGTTSALLMGLSLIATTSQPAKADWWDVGKQIIEDNLNGIRGNTVGRIYDQTFIAELSSEEVGQYKQRWGGNYSAKISDWCNDTVYQAGWRNLAGNQIPFVNTTWREENGKVNCYVRHAAQ
>NC_019751.1|WP_015196025.1|319633_319933_+|hypothetical-protein
MRKPKSLGERELHLIRVYSNWNFGMTPIEFYTKWEVSYEQIALICDRSDSTVRRWFKQGDNRRYPNRNDLLNLALIDFLLEHFEEIPEHLRRLLCAENF
>NC_019751.1|WP_015196024.1|319267_319537_+|hypothetical-protein
MQIQCVRFCLIFSPKAEKQLDDLPNKDRKQYDKAFKCFIQNSPAYRSLRTHRYCSKDGDIWSSSASMAKRFYWRYLEGDIIEITHIDSH
>NC_019751.1|WP_015196023.1|318737_319016_+|CRISPR-associated-endonuclease-Cas2
MFYLVCYDIVSDTRRNKVSKLLESYGLRVQKSVFECVLDEKQYESISKLLMRLLNRREDQVRFYPMSAHNRCKVAVVGTQPEFSVDDAAFIV
>NC_019751.1|WP_015196022.1|317685_318726_+|CRISPR-associated-endonuclease-Cas1
MSTIYITEPDASFKLQNKYLKLLQQDKQRFFIRISNISQFAIFGNIKLPKDVMQIVRLNQIPAIYFTHTGEYVGRLENPSTVQAKYLNYQRQRLHDREFNRATAESIVWAKLHNQQTFLQNWTRYCTDYTTQRASDYLTLLMDNLSLAPCVEELHQYIEEADKVYYCAVASILSLYSSNPHTTAKQINRFLNLGNQLLHQYIYNHLKTAGLHPDYSILHRDTHHELPLAWDFSAEFRAPIVDDLVLNFVRNLAKNNGNGNGNGKKPYTHLQRFLQHWEGKLKTFVLHPSAGEVSYRQCIDLQVKEYIASLLGDVEYYRPLALKFHPEQTNFINMLETQKPILTLVK
>NC_019751.1|WP_158333119.1|316385_316526_+|hypothetical-protein
MAETLILSFYPTNRYPGKGLMLLEYGLITKNYQLFRKNFTPHKKWR
>NC_019751.1|WP_041738925.1|329011_329272_-|hypothetical-protein
MYLNFWRDRISLLYYISESDRTCKYLSSGTPRVGVSYHDISRKISKSTLFLANRSGVLQVIGFWELKPLSVKAFSYFSLKGGLPNF
>NC_019751.1|WP_015196031.1|329577_331143_+|hypothetical-protein
MPKYTAITFAPVQGFIEKSRKLRDLYGSSQILSYLSQELLNEAGKTTEVVSPAIIKMQKGMPNRILLKGDFTEKQARDTLSSAWKRILFECRSWIGTKLPEKSYGTYHWEREWQNWGNYAWEVFCGSGDTISAAMEDLETKKLSRDWIGVNWIGESSSLTGTDAIAFPGLGAESRNPNNRKWSAEKEEIKTFYRRLACVLEGISLDKEPEGKYIALEEKLSIPELVKRLVTHEDIATSLGISPLGNSFSDIYRRPEKITETEKGRCTGWFMGDGDKVGDYLKDLAQKSDAEVKLFSQAMREWGRDFARDFPKEFGRVVYAGGDDFLGAIYSDKDKPKIEPEQVYQWLLELPNKWREHKQPINVSVGFIWAASSVPQRDILQHCREAEKVAKSLGRNRVTIRILFNSGQYVEWTCPWNYLNILDKYKDLDGNSNWSHIYTDLAQLEARNAFNIDKRTFNRKFALDFFDIYFPGEGEKLSKDNNLLKNIVGYTDDDEEYERVEKTIDWMRSLIKVGFQLCSNT
>NC_019751.1|WP_015196032.1|332141_332951_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MYKKAFGIIETLAPLHVGATAGEESGNLNLIFRDQFTQTGIIPGSSLRGRFRAEMRSQVDEKEVSYWYGEGASSEQSEINNESMVKFEHASIVWLPVFCPGQPIVWVSSPRLLERYKRIAQIDAEIPSLYVASSNIRARESQGKKTIFFNLGFLNIIRSENLSKWFPNGKELPAVIVDDSDIAMIHDMALYRQSRVRLKDNEKVVDGGGFFNTEALPEGTILVFPIAIRDDKSNKKWQPFPNDITDEIYLGGLESIGFGHCQLKIVNRN
>NC_019751.1|WP_015196033.1|333002_333431_+|hypothetical-protein
MNWQPYNLDQEAQRLVLAFRNKEGVIGQSHKMRVTVAYGLERFWGEHLRLLGKNDAKEREKGKYWQSVWKEFVRIMKRTGVELPSDEISDRNTEQIEEVAKKLWSLSLDDQKICLSVLTQFCDSLVWWTQRYKKAGDREEEV
>NC_019751.1|WP_015196034.1|333427_335047_+|hypothetical-protein
MTNYREIPLMFQAQIKGRGQIQYIAQPEKAYRWVDEWEEGVGNDVSNFSNRVSTKEYKITWRFISNSGQDDDVIRPVIASGGFPYYPGASMKGAFLRSCTPEQAMHYCGGIASKADSTTKPGILRFHGGYPKDATWKDKELVDVVHPQADWQLKDSSSHSAFIQISLHEPTLVFGISSNIKIESSEWDTIWSIWEKALERGIGSRVSAGYGQPVKHPETKLLTVGLTGQGLASQLINKTGEFRPNMFKAALRGHTLRLFAGITDENSAEALTRELWGGFAGKDGAVVGDLGIVFNPLELEMDGYRYRGNSIPTYELNNGILHILSMRSVSEEYKTELRSLAIKLIQFSLLLGGFGKSWRRIDHRIFFPDYLKNNQKPMIGCHWEFHQGAEKLYIPTNRLENISKFFTTLDEKIHQWIIANNKKTSNNLSQWREVWHPQKVQVWARVAEDEDDSSAVHWFHGEYKEGGTIKGSTLTGQIGQIGRIWHRMYPRYSKLKDGTMRRMGDEYIELLTIFPDTSNTTTQFIDFLGKSYFKRIYPS
>NC_019751.1|WP_015196035.1|335224_336832_+|hypothetical-protein
MAIWIITTGNSDVRIKKENNWNTIFHTIRDNLECTDFASPIPINPNAIEEGYTLPARVLGVAYSQIIEQEPKYFDELEFPLIETFCQKLKSEKKLEKKSHKLEQIFVLTTDQNNLFPNKWDRINEKCPYWQDTIELQTLLEKYLKTQFDIPIEFISLCPNSDEGLDYWDATLKLVETEFSQKFAKLQDKIVYVSHQAGTPAISAAVQFASLGIFGKVEFLVSNQYYDASYNHQAKAKIIDSSEYWRGLQIQKAKPLIRNGFPSTALKLLDGIDRIDKNIILQLEQMVDFFNLKSQSQNTNPDSIKEDFGIPNATQRIVDGLDLIGFFFKQNNYLPGISLLAAAQETFLKVAIKSEIQKNTANYCGIPVAELVKWTTKGLISPNNDELRNILKLPNSQNIDKVRNDIFDLLKFPYSKHNDRFYLYSIKQDLEFSRTGMLEWLLILAPNFREWAHLRQSNLRNQVIHNLRGIEEEEVIAYLLGLRDYQPIPNNITTAMDAYIQKVKQPFMQAIVLLKLPCEKGKLQERLNAIADSLI
>NC_019751.1|WP_144051088.1|337174_338395_+|ISL3-family-transposase
MKVLTELLDLKDIKVTSQRIYNGIGIILQTESTKSYSICPHCGTKSEKLHQNHSHIIKDLPFSEKPVFLEVNRRQFKCYQCQKPFSEELYYAKKKRTYTNRLAQKIIQDVLESDIHSVASKGIVTTEEIERMLKDASEELCDSKPSNLKRLGIDEIALVKGKGDYCAVLVDLDASKLLAILNGRTQDKIKEALSGWGLEVLQQIEEVSIDLWQGYKNLVMELMPNAQVVADRFHVMTQINKELDTQRKRERRSIEEQIKETKSESEKAEYEIILAGLKNSKYSLLKNEDNLTDEQVVKLREVKRVSPVLKEMHDFKEKIRKIFNLTDHWYTGVFKLGMWLSKAKKYFPRSNNTIIRWFDEIIAYFDNGTTSGTVEGINNKLKLIKRSGYGFRNFQNFKIRCLLNWT
>NC_019751.1|WP_015196036.1|338483_338750_+|hypothetical-protein
MNIINITFTHPFAKAPKHVFGQQVTIKSNCDRKKWAKGQITGLRLDYNSPNTWNYTVVFDYPQGFCEEFTEEDLAAVDELVCSQLLFK
>NC_019751.1|WP_015196037.1|338872_339235_+|hypothetical-protein
MKTPQQIEAALNQFTGSTTLYKHWLGLKYTDGIKYLAEETSCYWLLDAIFSHQTKTFLSNQNLREFQIWYLRVENNSGVLICEWDTNQEVLRQEIEYTDFSLSHIKLYLIETVLMLPSEY
>NC_019751.1|WP_015196038.1|339270_339516_+|hypothetical-protein
MLQAISSGQTFVTNLEQFMTKADKFIKIYYAGISEESKVREIVQELQNLLSDTDLQQLEIDYQHYCEIKDLMSDCDDSAWF

Crispr_ID: NC_019751_4

• CRISPR_ID: NC_019751_4
• CRISPR_location: 1085419-1085526
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_4

Consensus_repeat	Method
TTAATGGGTTTTGTGGGGTTATGCGA	CRISPRCasFinder

spacers of NC_019751_4

>4.1|1085445|56|NC_019751|CRISPRCasFinder
AGCTTGCGCGACGTAGCTTGTCCGACGCAAGTCGTAAGTCGTTCGCTTTGTGGATT

CRISPR arrays and Neighbor proteins around NC_019751_4

CRISPR arrays

The CRISPR arrays of NC_019751_4

>merge|NC_019751|4|1085419-1085526|CRISPRCasFinder
TTAATGGGTTTTGTGGGGTTATGCGAAGCTTGCGCGACGTAGCTTGTCCGACGCAAGTCGTAAGTCGTTCGCTTTGTGGATTATTAATGGGTTTGTGGGGTTATGCGA

>NC_019751|4|4|1085419-1085526|CRISPRCasFinder
TTAATGGGTTTTGTGGGGTTATGCGA	AGCTTGCGCGACGTAGCTTGTCCGACGCAAGTCGTAAGTCGTTCGCTTTGTGGATT
ATTAATGGGTTTGTGGGGTTATGCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015196644.1|1088619_1088982_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196646.1|1090611_1092048_-|MFS-transporter	unknown	unknown	gnl|CDD|225121
NC_019751.1|WP_015196632.1|1078050_1078476_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196630.1|1073224_1076110_+|cation-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319781
NC_019751.1|WP_015196640.1|1085823_1086063_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196635.1|1081663_1083010_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226361
NC_019751.1|WP_015196636.1|1082966_1084673_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NC_019751.1|WP_015196633.1|1078612_1079083_-|MgtC/SapB-family-protein	unknown	unknown	gnl|CDD|224204
NC_019751.1|WP_015196648.1|1093228_1093822_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|368581
NC_019751.1|WP_015196637.1|1084838_1085129_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl|CDD|226194
NC_019751.1|WP_015196631.1|1076456_1077578_+|DNA-replication/repair-protein-RecF	unknown	unknown	gnl|CDD|234608
NC_019751.1|WP_015196641.1|1086083_1086521_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196645.1|1089339_1090557_+|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224172
NC_019751.1|WP_015196647.1|1092183_1093140_-|DUF4351-domain-containing-protein	unknown	unknown	gnl|CDD|316753
NC_019751.1|WP_015196629.1|1071187_1072864_-|transglutaminase-family-protein	unknown	unknown	gnl|CDD|224224
NC_019751.1|WP_015196639.1|1085560_1085827_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl|CDD|224937
NC_019751.1|WP_015196642.1|1086555_1087881_-|cytochrome-P450	unknown	unknown	gnl|CDD|215171
NC_019751.1|WP_015196638.1|1085125_1085314_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015196634.1|1079170_1081486_+|phosphoenolpyruvate-synthase	unknown	unknown	gnl|CDD|273612
NC_019751.1|WP_015196643.1|1088232_1088511_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015196646.1|1090611_1092048_-|MFS-transporter	gnl|CDD|225121	COG2211, MelB, Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism].	1.87897e-115
NC_019751.1|WP_015196630.1|1073224_1076110_+|cation-translocating-P-type-ATPase	gnl|CDD|319781	cd02089, P-type_ATPase_Ca_prok, prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1. Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_019751.1|WP_015196648.1|1093228_1093822_-|methyltransferase-domain-containing-protein	gnl|CDD|368581	pfam05724, TPMT, Thiopurine S-methyltransferase (TPMT). This family consists of thiopurine S-methyltransferase proteins from both eukaryotes and prokaryotes. Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes S-methylation of aromatic and heterocyclic sulfhydryl compounds, including anticancer and immunosuppressive thiopurines.	2.242e-32
NC_019751.1|WP_015196635.1|1081663_1083010_+|AAA-family-ATPase	gnl|CDD|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	0.00128126
NC_019751.1|WP_015196636.1|1082966_1084673_+|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.65345e-13
NC_019751.1|WP_015196645.1|1089339_1090557_+|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	2.23329e-131
NC_019751.1|WP_015196637.1|1084838_1085129_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl|CDD|226194	COG3668, ParE, Plasmid stabilization system protein [General function prediction only].	1.11359e-13
NC_019751.1|WP_015196631.1|1076456_1077578_+|DNA-replication/repair-protein-RecF	gnl|CDD|234608	PRK00064, recF, recombination protein F; Reviewed.	2.29983e-144
NC_019751.1|WP_015196647.1|1092183_1093140_-|DUF4351-domain-containing-protein	gnl|CDD|316753	pfam14261, DUF4351, Domain of unknown function (DUF4351). This domain is found in bacteria, and is approximately 60 amino acids in length.	6.56567e-23
NC_019751.1|WP_015196629.1|1071187_1072864_-|transglutaminase-family-protein	gnl|CDD|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	5.63438e-23
NC_019751.1|WP_015196639.1|1085560_1085827_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl|CDD|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	3.0857e-20
NC_019751.1|WP_015196633.1|1078612_1079083_-|MgtC/SapB-family-protein	gnl|CDD|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	1.84952e-42
NC_019751.1|WP_015196642.1|1086555_1087881_-|cytochrome-P450	gnl|CDD|215171	PLN02302, PLN02302, ent-kaurenoic acid oxidase.	5.51483e-91
NC_019751.1|WP_015196634.1|1079170_1081486_+|phosphoenolpyruvate-synthase	gnl|CDD|273612	TIGR01418, Phosphoenolpyruvate_synthase, phosphoenolpyruvate synthase. Also called pyruvate,water dikinase and PEP synthase. The member from Methanococcus jannaschii contains a large intein. This enzyme generates phosphoenolpyruvate (PEP) from pyruvate, hydrolyzing ATP to AMP and releasing inorganic phosphate in the process. The enzyme shows extensive homology to other enzymes that use PEP as substrate or product. This enzyme may provide PEP for gluconeogenesis, for PTS-type carbohydrate transport systems, or for other processes. [Energy metabolism, Glycolysis/gluconeogenesis].	1.03392e-118

Protein sequences

>NC_019751.1|WP_015196638.1|1085125_1085314_-|hypothetical-protein
MEKLNIKEEARKLIDKLPDNSTWDDLMYEIYVRQVVEAGLVDSQAGNVTSVQEVRAKFGLPE
>NC_019751.1|WP_015196637.1|1084838_1085129_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MKVFWTETAVENLSAIYNYISQNSPQYATRIIDRITRRSQQIVNFPLSGRIVPEFETEQIREVIEGSYRIIYYIKPEQIDVLAVIHGAQEITSGIE
>NC_019751.1|WP_015196636.1|1082966_1084673_+|tetratricopeptide-repeat-protein
MSSSNKPSKQPSNHNSSENQAEIGKFIATNQDEFAELVTFIDFAEKFTLGFIEINFPPDINLLIAGLQQNSQCQEIQFVILDFPEKNLRFLRDELVRQLAEITKESNKKLVLLIRNLEKSIGVFGDYPPILQDLNFVRDSYRQTVPHPLLFILPDYAISRLAKFAPDFWAWKSGLFRFKTTELTRDRAIASTLDADTNIARLPTPEQQERIDLLHSLLMEYKPTGEIPNQENLRNCGNILNELGTAYLSQHKPSQAREYLKEAWKITQEFSDYSLEIRVINQLGGSYSQQRQFATARSYHQQALNIAKKQESNHAVANCLFNLGNVSLDTRQFQQARDYYQQALEIKIELGARFESARTYHQLGRVAQQLREYEQARDYYQQALEIKIEFGARYDSASTYHGLGILARKLREYEQARVYSQQALEIKIEFGARFESAGTYHNLGIVAQQLREYEQARVYYQQALEIKIEFGARFESASTYGQLGLLAQDLREYPQARDYYQQALEIYIEYGDRYSQALTLYCLGTLAKAEENYAEARANLQTALEIYVEYQDEYMATMMQECLEDLPE
>NC_019751.1|WP_015196635.1|1081663_1083010_+|AAA-family-ATPase
MSQSSFQRANTLKAAFLACNVEPLEPAEMERYYVDLSSVRKTSAIDNVSTILDFQEAGDFTTILFTGHRGCGKSTELKRIQSLWENNYHVIYLEANEETDINDARYTDLYLIVIKQVEFELRKLGLTFDDKLLKSFESWFKDITQENEQSVEKSVNVDAEATLSPTAPFLAKLMVKLLAQIKGSDKQKTTIRQTLEKDLSRLKSDTNLLLSDAYVKLRQKFPECKGLLIIFDNLDRVPPVVAEHLFFDYAAQMQELNCTIIYTVPISILCSPKNPLNQFDGNPHIVPMINIYEFERHKCELNYDQKGLDIIASVIEKRVDVDAIFESRNQLLELAKASGGHVRQLMQMMRSACQTASTRKHAKIMSEDIDYAVKQQQFTFERFIPEEHYAHLAQVCLTKDVSKDEVGQLMLFNTSVLEYNGDKRWNYPNPVVKQNEFFQQALKAAQQP
>NC_019751.1|WP_015196634.1|1079170_1081486_+|phosphoenolpyruvate-synthase
MDKLYWLEEIELQDYAKVGDKALNLSKAIQRGYPVIPGFVVGVGVLREFLETLSSSEALVADLPHSSLRLDVGNWRQLQQVARSLRQEIIAATIPQNWLDQILAAVEDWDSKHLIFRPTFVLPTKINFGKNISGLLESQVCLRDRTLIETTLKQVWSQLFRARSLLYWQRLGIDMSQINLAVLVQPIENAIASGSLVANSEICEIHGTFGLGFPLNYGEIIPDYYKVSCRDGIILERQLGKKILGYQLDYNSLSPYLINQELNHQFSLSNDDCQQLVSLTKKIPIPDHTNFRFDWTILQHRGKDIVYLTQALFPQTAANLHLICQGLGVARGVVTAPVHVITRHQETISELTPGVILVATVIVPEWLPLLHSCSGIITERGGFTSHAAILARELGIPAVVNVSGATNIIHSGDRLLINGDSGEIFSIKKGSHGEPSMERLEPGVHSISELDVADLARDNSVVPLGNVYPTIATKLFVNLSQPSSLKTIENLPIDGVGLLRSELMTVGLLEGKSPQSWLDEGRERELIERWYQQLLLFVKAFAPRPIFYRSLDLQSNGIQLTRSHDESQHSNQGILGERGTLGYLQNSAVFEVELAALGKLQQNGYHNINLILPFVRSVEEFRFCRRRIEQAGLMDVSQFQLWIMAEVPSVLFLLSEYVKAGVQGIAIGSNDLTQLLLGIDREKSKPTRTLDERHPAVMNAIAQLIQMAQNENIPCSICGQAPSLYPEIIDSLVRWGITSISVEPNSIPQTYHAIARAEQRIILNAARRQMM
>NC_019751.1|WP_015196633.1|1078612_1079083_-|MgtC/SapB-family-protein
MFSIHQILSNNWLQITLRLSFALILGAIIGLERELKHKPAGLRTHMLVSLASAIFTLIPWELTGGGSNLDTNNLSRIIQGIAAGVGFLGAGEILRASSQTSQRPEVHGLTSAAAIWVSASLGIAAGCGLWELGLIGGVFTFLVLYVFKRFEKSSLK
>NC_019751.1|WP_015196632.1|1078050_1078476_+|hypothetical-protein
MNQLIERNEIITLGKSLREIQPQLLKQNYQEGAKRMWFQGEEPYFDVFFETQNHQITWFQFTLRGKTLSWDNSKPGWQTGISNELKINDVSFYAASKLIENDPEIDWEFIKLVKSILEIQTHEEMFVKALELFDEKTFPST
>NC_019751.1|WP_015196631.1|1076456_1077578_+|DNA-replication/repair-protein-RecF
MFLQSLHLRYFRNYKEQFVEFTAPKTILVGNNAQGKSNMLEAVELLATLRSHRLARDRDLVQDGQAIAQIKATLKRDTGNHDLTLTLRRNGRRTVARNSEVVRRQMDFLGILNAVEFSSLDLELVRGGPDLRRHWLDTLLLQLEPIYTHILQQYNQVLRQRNAFLKQHVETTPDPEQLALWDAQLVATGIKVIRRRDRAIQRLAPIAAMWHANISKSTEVLEIKYSPSIPFEESQPEQVQESFFDRIQQRTIAETHQGTTLVGPHRDEIELVINQTPARQYGSQGQQRTLVLALKLAELQLIEEVVGEPPLLLLDDVLAELDPSRQNQLLDTIQDRFQTIITTTHLGSFDAQWLKSSQILTINSGQILSQAIF
>NC_019751.1|WP_015196630.1|1073224_1076110_+|cation-translocating-P-type-ATPase
MSAHSLPDLAANWHNVETSKAIEMLSTDADNGITSQEVEQRLLKYGTNELEETGGRSAWEILVDQFKNIMLLMLIAVAFISGALDLLAWQQGTLKPGEIPFKDSIAILAIVILNGILGYVQESRAEQALAALKKMSSPNVRVIRDRKVVEIAGKDLVPGDVMLLEAGVQVAADGRLIEQSNLQIRESALTGEAEAVSKRSEIQLPEDTSLGDRINLVFQGTEVVQGRGKVVVTRTGMRTELGKIAELLQSVESEPTPLQQRMTQLGNVLVAGSLILVAIVIIGGMIHAYFIAGARENDLFNRLQELVEVSLSMAVAVVPEGLPAVITVTLALGTQRMVKRHALIRKLPAVETLGSVTTICSDKTGTLTQNKMVVQSIYAKNYEFKITGDGYAPQGDFALNQRTVSLEEHPEVSSLLVACAVCNDSFLQQENGTWGIIGDPTEGALLTLAAKGGIEKDQWSSKLPRVGEIPFSSERKRMSVICEVQTVTNGFSPVVDVDPTIREIANEKYLMFTKGSPELILERCDRIDAGTKSYAITSEQRQIILAENDKMASNGLRVLGFAYRPLPEVPPDGEGEATEQHLVWLGLVGMLDAPRPEVRDAVKECRAAGIRPIMITGDHQLTARAIAKDLGIAENSNDRVLVGQELQKMSDQELEQQVDLVSIYARVAPEHKLRIVQALQRRGRFVAMTGDGVNDAPALKQADIGIAMGITGTDVSKEASDMILLDDNFATIVAATKEGRVVYTNIRRFIKYILGSNIGEVLTVAAAPLLGLGGVPLSPLQILWMNLVTDGLPALALAVEPPEPDVMKRAPFSPRESIFDRGLGSYMIRIGIVFAIITIAMMVWAYQHSHAPGYTGDPDTWKTMVFTTLCIAQMGHALAIRSNNQLTIQMNPFSNLFVLGAVVFTTILQLMLVYVAPLRNFFGTHVLTGQELLICIGFSALMFVWIEGEKIFFRLIGKKTI
>NC_019751.1|WP_015196629.1|1071187_1072864_-|transglutaminase-family-protein
MGSALTSFPNSQMFGQRTIRPLCAAALGGIAFIKNTLIAIDSNRGYLLQVDPVTDNTKILNPHHTSEFMDITGISLWEDTLWVTRGKSIYLCKFNSWGLEHFITLPYQADGIAVWGSTVYVSCQKMGAILIYDCETRRKITQFYAPGVGIANLAVCEETLWVADKVEQTIFALDRATGDIRFSILTPFECPTGLAVHSNSESGKETIYVAYASEEAFIRDNPNADPSQELAYRDRTFIHPLSYHYDPQTRCCLSNGYRIEMSYIEEIAPLEEVYLPEVEWRIALPSNTDRQRVVSVEAVGLPFSEEIIDGQKVAVFKFETLVPGERHLFGWKAILEVRGVKYRLTPRDVENIPELSEEFQTRYLVDDDELAMDNTIVQDAAKVAVGSETNLLRKMYSIRNYVYDQLSYSIKPHIDAPDVVLERGTGSCGEYVGVLLALCRLNGIACRTVGRYKCPPYADHQGIPLEPDFNHVWLEFYIPSIGWLPMESNPDDLGYQSAHPTRFFMGLSWYHIEIGKGISFETLMSKGERLKKEDISIGELAINHIRFKIIEELPPLNQ
>NC_019751.1|WP_015196639.1|1085560_1085827_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MSYKVEILKGALKQLKKLPSELQERIQVKIDDLAIEPRPNGVKKLKGKENTYRIRVSDYRVIYDIFDDNLVVSVVEVGHRGKIYKDES
>NC_019751.1|WP_015196640.1|1085823_1086063_-|hypothetical-protein
MKSEQEREQLIKEINILLHQSYDSTLDDIYALLQKIEAEEEEEDLKAYNKAREASKIDDSMSWEEAKKELRTEIKKEVA
>NC_019751.1|WP_015196641.1|1086083_1086521_-|hypothetical-protein
MNAQLTADEINSVRDLLKEYQPANKAIATLEHHNGNLDTSFEELWIEKNGKPTMGSKNIWQTTLDVVRDELCGDEGFRARLSDYTKSPENAVLLTATITSLMALTAIPLDPSIATIIVLYILKIGLNVYCQYTEPSDGKNLPPSN
>NC_019751.1|WP_015196642.1|1086555_1087881_-|cytochrome-P450
MSSTKNLPLPPGKLGLPLLGETIDFLRDRSFSQKRQNWYGNLYKTHLFGRPTIVVIGADANRFLLTNENTYFTSSFPKTTKELLGAASLAIQKGGEHLQRRKLLSQAFQPRALSGYVGGMEAITHGYLQKWEKIGDLTWYPELKKYTFDVACKLLIGTDTASDDEIGQFFEEFSEGLFSLPINLPWTKFGKALHAREQLLMKIEQIILQSQQQTASSQDALGLLLQATDEDGSKLSIKELKDQVLLLLFAGHETLTSAIASFCLLLAQHPDVMAKVRTEQQNFDFSQPLTLESLKEMTYLEQVLKEVMRVIPPVGGGFREVIQTCEFNGYQIPQGWAVLYQVNRTHRDESIYTEPDSFEPERFNPDRAEDKTKPFSYMTFGGGVRECLGKEFAKLEMKIFAALLIRKYQWELVNGDKPEMAMVPTPRPRDNLQVRFGCLSK
>NC_019751.1|WP_015196643.1|1088232_1088511_+|hypothetical-protein
MNRAFRKYHRTIAMIVSLPLAITVLTGMATTMVQQWSFSFGISRSIILQIHTGKIFHLEGIYPILNGLGLIGLLVTGLTMTGLFRGKAKKPS
>NC_019751.1|WP_015196644.1|1088619_1088982_+|hypothetical-protein
MNSITAQELKEYRLLLSDYPDNTALDGLNAVEQCQGNLEDALALLVNQSGTRQLLQIELDNLAQMCRNAVCSQPTEDFIGLLNIVSGFLPPPASLAVPVALYIIKLGVRNYCQISNPGSK
>NC_019751.1|WP_015196645.1|1089339_1090557_+|NAD(P)/FAD-dependent-oxidoreductase
MSQQSAKICILGGGFGGLYTALRLSKLPWEGDKKPEIVLVDQSDRFLFSPLLYELLTRELETWEIAPPFVELLANTGVRFCQGTVAKVNIEQRLVHLQDGSDISYDRLVLALGGETPMDLVPGAEAHAYPFRNVNDAYRLEERLRILEESETDKIRIAIVGAGYSGVELACKLADRLGDKSPDRSRDRARLRLVELSDKILGTSPKFNREAATKALEAKGVFIDLETKVESISQDSMSLEYKEQVDTIPVELVIWTVGTRVSPVVQSLPFQVNQRGQIQVTSTMQVLEHPEIFALGDLVDCQDAEGQKIPATAQAAFQQADYTGWNIWASLTNRPLLPFRYQYLGEMITLGVDNTTLAGLGVTLDGPFANIARRLAYLYRMPTLEHQLKVGFNWLTRPVIDLLSS
>NC_019751.1|WP_015196646.1|1090611_1092048_-|MFS-transporter
MGDSTSDRLSDRNPPESKLNLSTKLAFGAGDMGTAITAMIGISYSSMFLTDVAGLSPSLAGSTQSLGKIWDAVNDPLVGVLSDKNHPQNKWGRRYPWMIWGAVPFGFFFFIQWIVPQNFSQAGLFCYYTAASILFNTFYTVVNLPYTTLTAELTRDYDERTRLNGFRYVFSIAGSVLAIAITLTITAMFREDRVLQALTIGAVCATISILPIYWCVWGTRKRSQYMKSRNPETEASISLPFLQQLRITLTNIPFLYVIGIYLCSGLSFQLTAGIVPYFIVSWMRLPQLHVSLVFLAIQGTAMVMLFVWSYISRRIGKKAVYMMGTIAWLIAQIGLYFLQPGEVGFLYGLCVIAGIGVSTAYLIPASMLPDVIELDELRTGQRREGVFYSFAVFIQKISLGFAIDIMLKSLGWAGYIKPTKDILVPIQPDSVLQVIRFFISPLPAIALFIGLILTYFYPITREAHQEILLELEKQKNHK
>NC_019751.1|WP_015196647.1|1092183_1093140_-|DUF4351-domain-containing-protein
MIDHDQLFKKLLENFFPEFIELFFPDITNYWERDTIEFLPQEVFTDITAGEKKIVDLVVRVSFRNQDSLFIIHLEHQSSSQADFNVRMFTYYARLHEKFSLPIYPIVLYSHDSPRDSEPNNYTIEFPGWKALEFNYKVIQLNQLNWHDFVNQPNPVASALMSKMRMDKQERPTVKLSSLQLLVTLGLNPAQIELISKFIDVYLELNIEEEANFKSQLATIEPRQEEEVMEILTSWERRGIEQGREQGREQGREQGKQQEASAMVLRLLNRRVGALNPQLQERIQQLPTPKLEDLGEALLDFTAITDLEIWLNSDENLN
>NC_019751.1|WP_015196648.1|1093228_1093822_-|methyltransferase-domain-containing-protein
MPNQEYWEQCYQEGNTRWDLGTAAPPFLSLLKSENPPSPGRVAVLGCGRGYDAILFAKYGFEVVGFDFTVAAIRDATTLAKSENISAEFLQRDIFDLPGEFAGEFDYVIEHTCFCAIARSLRLDYVQLVKSILKPQGQLIGLFFTHSRPDGPPFGTNPAEIREYFQPDFEILSLKPVLNSVPSRQGEEHLGRFQVVK

Crispr_ID: NC_019751_5

• CRISPR_ID: NC_019751_5
• CRISPR_location: 1591761-1591849
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_5

Consensus_repeat	Method
AAGCGATCGCACTCCAACCCAAAC	CRISPRCasFinder

spacers of NC_019751_5

>5.1|1591785|41|NC_019751|CRISPRCasFinder
CCTCATAACTGCGATCGCACTAATCCCACAAACCCCAATAA

CRISPR arrays and Neighbor proteins around NC_019751_5

CRISPR arrays

The CRISPR arrays of NC_019751_5

>merge|NC_019751|5|1591761-1591849|CRISPRCasFinder
AAGCGATCGCACTCCAACCCAAACCCTCATAACTGCGATCGCACTAATCCCACAAACCCCAATAAAAGCGATCGCACTCCAACCCAAAC

>NC_019751|5|5|1591761-1591849|CRISPRCasFinder
AAGCGATCGCACTCCAACCCAAAC	CCTCATAACTGCGATCGCACTAATCCCACAAACCCCAATAA
AAGCGATCGCACTCCAACCCAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015197067.1|1584462_1585527_+|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl|CDD|379142
NC_019751.1|WP_015197075.1|1601871_1603350_-|SAM-dependent-DNA-methyltransferase	unknown	unknown	gnl|CDD|223363
NC_019751.1|WP_051036615.1|1609504_1610074_-|hypothetical-protein	unknown	unknown	gnl|CDD|341135
NC_019751.1|WP_015197064.1|1577457_1581840_-|CHAT-domain-containing-protein	unknown	unknown	gnl|CDD|378942
NC_019751.1|WP_041740314.1|1588436_1590305_+|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl|CDD|378147
NC_019751.1|WP_144051010.1|1594866_1595103_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_083866295.1|1591936_1594270_-|hypothetical-protein	unknown	unknown	gnl|CDD|238121
NC_019751.1|WP_041740312.1|1585888_1586623_-|DUF3598-family-protein	unknown	unknown	gnl|CDD|371960
NC_019751.1|WP_015197066.1|1583663_1584137_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197063.1|1576717_1577116_+|PIN-domain-containing-protein	unknown	unknown	gnl|CDD|350220
NC_019751.1|WP_015197065.1|1582162_1583515_+|hypothetical-protein	unknown	unknown	gnl|CDD|373105
NC_019751.1|WP_015197072.1|1591116_1591683_+|hypothetical-protein	unknown	unknown	gnl|CDD|377670
NC_019751.1|WP_015197074.1|1600749_1601781_+|CHAT-domain-containing-protein	unknown	unknown	gnl|CDD|378942
NC_019751.1|WP_015197078.1|1611664_1612666_-|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341187
NC_019751.1|WP_015197076.1|1603673_1608128_+|NACHT-domain-containing-protein	unknown	unknown	gnl|CDD|238121
NC_019751.1|WP_041740313.1|1586727_1588110_-|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl|CDD|215283
NC_019751.1|WP_015197077.1|1608237_1609512_-|hypothetical-protein	unknown	unknown	gnl|CDD|377943
NC_019751.1|WP_015173935.1|1596394_1598062_-|IS1634-family-transposase	unknown	unknown	gnl|CDD|379471
NC_019751.1|WP_083866360.1|1594404_1594620_-|hypothetical-protein	unknown	unknown	gnl|CDD|372577
NC_019751.1|WP_015197071.1|1590308_1591160_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|379165

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015197067.1|1584462_1585527_+|trypsin-like-peptidase-domain-containing-protein	gnl|CDD|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	4.49095e-21
NC_019751.1|WP_015197075.1|1601871_1603350_-|SAM-dependent-DNA-methyltransferase	gnl|CDD|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	2.03024e-71
NC_019751.1|WP_051036615.1|1609504_1610074_-|hypothetical-protein	gnl|CDD|341135	cd17246, RMtype1_S_SonII-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Shewanella oneidensis MR-1 S subunit (S.SonII) TRD2-CR2. This model contains Shewanella oneidensis MR-1 S subunit (S.SonII) TRD2-CR2 and similar TRD-CR's. S.SonII recognizes 5'... GTCANNNNNNRTCA ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases. S.SonII TRD1-CR1 does not belong to this subfamily.	6.44307e-21
NC_019751.1|WP_015197064.1|1577457_1581840_-|CHAT-domain-containing-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	9.05678e-62
NC_019751.1|WP_083866295.1|1591936_1594270_-|hypothetical-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	9.66413e-117
NC_019751.1|WP_083866360.1|1594404_1594620_-|hypothetical-protein	gnl|CDD|372577	pfam13359, DDE_Tnp_4, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	8.80862e-09
NC_019751.1|WP_041740314.1|1588436_1590305_+|DDE-type-integrase/transposase/recombinase	gnl|CDD|378147	pfam09299, Mu-transpos_C, Mu transposase, C-terminal. Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology.	1.50025e-12
NC_019751.1|WP_041740312.1|1585888_1586623_-|DUF3598-family-protein	gnl|CDD|371960	pfam12204, DUF3598, Domain of unknown function (DUF3598). This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 230 and 398 amino acids in length. These proteins are formed entirely from B sheets which form a barrel structure similar to those seen in the lipocalin superfamily.	1.60256e-70
NC_019751.1|WP_015197065.1|1582162_1583515_+|hypothetical-protein	gnl|CDD|373105	pfam14516, AAA_35, AAA-like domain. This family of proteins are part of the AAA superfamily.	0
NC_019751.1|WP_015197063.1|1576717_1577116_+|PIN-domain-containing-protein	gnl|CDD|350220	cd09872, PIN_Sll0205-like, VapC-like PIN domain of Sll0205 protein and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Synechocystis sp. (strain PCC 6803) Sll0205 protein and other uncharacterized homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.17332e-11
NC_019751.1|WP_015197076.1|1603673_1608128_+|NACHT-domain-containing-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	1.11208e-102
NC_019751.1|WP_015197072.1|1591116_1591683_+|hypothetical-protein	gnl|CDD|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	1.00943e-11
NC_019751.1|WP_015197074.1|1600749_1601781_+|CHAT-domain-containing-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	9.74321e-08
NC_019751.1|WP_015197078.1|1611664_1612666_-|restriction-endonuclease-subunit-S	gnl|CDD|341187	cd17496, RMtype1_S_BliBORF2384P-TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Bacillus licheniformis S subunit (S1.BliBORF2384P) TRD1-CR1 and Chlorobium tepidum TLS S subunit (S.CteTORF675P) TRD1-CR1. The recognition sequences for Bacillus licheniformis S subunit (S1.BliBORF2384P) and Chlorobium tepidum TLS S subunit (S.CteTORF675P) are undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. This subfamily of TRD-CR's shows similarity to TRD1-CR1 of Aminobacterium colombiense DSM 12261 S subunit (S.Aco12261I), which recognizes 5'... GCANNNNNNTGT ... 3'. This subfamily may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	3.26311e-82
NC_019751.1|WP_041740313.1|1586727_1588110_-|Rieske-2Fe-2S-domain-containing-protein	gnl|CDD|215283	PLN02518, PLN02518, pheophorbide a oxygenase.	2.06985e-62
NC_019751.1|WP_015197077.1|1608237_1609512_-|hypothetical-protein	gnl|CDD|377943	pfam07929, PRiA4_ORF3, Plasmid pRiA4b ORF-3-like protein. Members of this family are similar to the protein product of ORF-3 found on plasmid pRiA4 in the bacterium Agrobacterium rhizogenes. This plasmid is responsible for tumorigenesis at wound sites of plants infected by this bacterium, but the ORF-3 product does not seem to be involved in the pathogenetic process. Other proteins found in this family are annotated as being putative TnpR resolvases, but no further evidence was found to back this. Moreover, another member of this family is described as a probable lexA repressor and in fact carries a LexA DNA binding domain (pfam01726), but no references were found to expand on this.	2.72635e-16
NC_019751.1|WP_015173935.1|1596394_1598062_-|IS1634-family-transposase	gnl|CDD|379471	pfam14104, DUF4277, Domain of unknown function (DUF4277). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is approximately 110 amino acids in length. There is a conserved NGLGF sequence motif.	3.30801e-50
NC_019751.1|WP_015197071.1|1590308_1591160_+|AAA-family-ATPase	gnl|CDD|379165	pfam13401, AAA_22, AAA domain.	1.11609e-11

Protein sequences

>NC_019751.1|WP_015197072.1|1591116_1591683_+|hypothetical-protein
MAEDIYLPKREIISNKEINKGDEILPRLGFVEPYECESISHYLGRVRRFKANSLPSGYSLGKIAGIGAVTTRWEKLYLNPFPSETELEALAKVIEVEVERLRQMLPPKGMTMKPRPIRLCAACYAESPHHRIEWQFKDVMVCDRHQLPLSTKCKNCGTPFPIPADWVRGECPHCCLSFTKMAKRQKSG
>NC_019751.1|WP_015197071.1|1590308_1591160_+|AAA-family-ATPase
MARSQLAIQSSVEVLVPQLDLNAQLAKVVEVEEIFSNYFIPTDRSSEYLRWLDELRILRQCGRVIGPRDVGKSRASLHYQGQDQKRISYVRAWSASSSKRLFSQILKDIKHAAPMGKRDDLRPRLAGSLEVFGFEQVIIDNAENLQKEALLDLKQLFDECHVPIVLIGGQELDTILDEFDLLTCFPTLYEFDGLDENDFKKTLNTIEFDILALPEASNLSEGIIFELLAESTGARIGLLVKILTKAVLHSLKNGFSKIDQNILEKIANRYGRRYIPPEKRNNK
>NC_019751.1|WP_041740314.1|1588436_1590305_+|DDE-type-integrase/transposase/recombinase
MADKKFELTEKFTQLPEAVFLGENNFVIDPSQIILETSDKHKLTFNLMQWLAESPNRTIKSQRKQAIASTLGVSTRQVERLLKQYDEDRLSETSGLQRSDKGKYRVSDYWQEFIKTTYEKSLKDKHPISPASIVREVKRHAIVDLKLEQGNYPHPATVYRILNPLIEQQERKKKVRNPGSGSWMTVETRDGKQLKVDFSNQIIQCDHTKLDIRIVDSDGILLTERPWLTTVVDTFSSCVNGFHLWIKQPGSAEVAIALRHAILPKQYPDDYELGKPWKIYGHPFQYFFTDGGKDFRSKHLKAIGKKLGFQCELRDRPIQGGIVERIFNTINTQVLKDLPGYTGPNVQERPENAEKEACLSIHDLDKILASFFCDIYNHEPYPKDTRITRFERWFKGMGEKLPEPLNERELDICLMKEAQRVVQAHGSIQFENLVYRGESLNAHKGEYVTLRYDPDHILTLYVYSYDVNDELENFLGYVHAINMDTQDLSLEELKSLNKERSKARREHSNYDALLALSKRKELVEERKQGKKEKRQAEQKRLRAASKKNSNVVELRQNRASSSSNKDEKDEKIELLPERVSREELKVEKIEPQLEILDKAETPPQERHKLVISSRKQHLKKIW
>NC_019751.1|WP_041740313.1|1586727_1588110_-|Rieske-2Fe-2S-domain-containing-protein
MMTNFSWTKQWYPVTPISYLEPSHPTAITLLGKNLVIWRDKQQKWVAMDDVCPHKLAQLSLGSIDKNGNIMCRHHGWCFDGTGTCTNIPMLSDEKALETACKSERSQITTYPTQVLQGLLWIWADNSPTAFEDSNLKQPALMPEFQLDSSATDWFMSEVPVGYTVSFESSFDPSHAQFLHNGIAGFSPERAIPMEHFEVSGEISAENGFTLKHSGYNIFNKDMDATRQFTPPCCNTTIYKYSNGKSALFQLYFVPTEPGYCKHIGKFITDTFSQKRNFWFELLPKYLQTGLRHSSSYKLSNQDLSMMHSQAMNESLEDKPWQKSYFMPSLADIGIVTFRKWLDEFAGGKPAWQGMKEVPFQELSDEQLYDIWHRHTKHCPSCRQSLVLIDKVKDYCQNFTAVLAILGLLLIVVNLPIKIVLLPVLLSILSLGCSYKLGLMRERFISSVPRKGLPVVDLYK
>NC_019751.1|WP_041740312.1|1585888_1586623_-|DUF3598-family-protein
MEAQNESWSNFCKYHVGDWHGNWTTFSSEGQLTNSIQCIRSFRLNEDGTEIQHHNHYTYEDGKKESKLYGNYNKSTLRSLFLKNCFSWGLKQVDSGTKFFFETGFRYEQRRISVVGIYKNGISIDSVLVISEHIADFPDKPTSTVKQITGINWNGISKTITDDYQVSSSEEKIWTALESLGIDYFTMHFSDGISISCPQVIEKGQHFLTVIDWQVLPTFWQRGIRKYDQSGFSSLTLEEFHKPQ
>NC_019751.1|WP_015197067.1|1584462_1585527_+|trypsin-like-peptidase-domain-containing-protein
MLSKIQNQFKSALVISALLSATLPIAPAKSQTSQPLQTNFSQTQQLTQANLVAEDVKPSVVRVVVGCKAKVYSPNTGKIYELEKITGHGSGFFVNPNGYAATNAHVTNPEDCQQILRADLAAKLEADGETLENVEAELKWIETKPIQLVYLPNQEQLPFEIINFGAVAGEGKDVSIIKVNLINAPVLKLAESNQVKLLDSVTVVGYPGLVETIPVFNEESFYEASFTRGQISAKKNLKDGTPILQITAPVPKGNSGGPVLNDNGEVIGLVTFGPDDNFTFIFTSDTIQEFLDSANISNQQGLVNQTYREGLQLYSRGEYSQALRKFELVKRLFPQHSEVENYLDKCQQVVANGN
>NC_019751.1|WP_015197066.1|1583663_1584137_+|hypothetical-protein
MLHKKLQATLFGTVAGITAIYGSLFVAVTPVRADDAEYSGQVRTQLMAAAIRVGLEGYSLTHDPFIDVLDHGRSDYITLNLRAGTSYGIVGVCDSDCRDLDISLYDSRGNRVASDLGNDDIPTITINPSRSGTYRIRVDMASCDTRNCYYGIGAFGQ
>NC_019751.1|WP_015197065.1|1582162_1583515_+|hypothetical-protein
MPRGIRVRPDCITLVKQRTLQKGFTRQIDLAERINRGQSTAYSFLNGKPVDYLNFLEFCNLLNFDIQEIADFEALADIYTEKTQIEKPQKTNNSPPSSSPLPELEYPEGQVPLNSPFYVERSPIEQRCYEEIKKPGSLIRIKAPQHMGKSSLLARILQEAENQGNRTVEIDFQLVEEEFFSDFNKFIHWFCDTVAEGVAGNNRELLEKLLQQLDEHWKTGQRFGYMKTCKNYFERYLFPEINQPLVLGLEAVDRLFAYPKIYKDFFGLLRAVHEEAKRRDIWKQLRLVLAYSTEVYAYGPVDINQSPFNVGLALDLPEFTHEQVKDLTQRHQLNWSDTEVEKLMGLVSGHPFLVRLALYKIARQEINLAEFLQTAATAQGIYSRHLQHLEEILQQQPELQTAMQEVASSDNPVNLPTAIRFKLHSMGLVHLHGNEVTPRCQLYRQYFCSH
>NC_019751.1|WP_015197064.1|1577457_1581840_-|CHAT-domain-containing-protein
MTGDYEYKVGGSLEEDAPSYVRRQADSDLYYGLKAGELCYVFNSRQMGKTSLLVRTMKRLQADGFACAVIDISGLGSQDITLEQWYGSIVDSLLTELNFVEPEDLAVWWEKSIEITPVRRLGKLFDELLLPNVNQNIVIFLDEIDSILRLDFPADDFFALIRSCYQRRSFKAEYKRLTFALFGVATPADLIKDEERTPFNIGTAIQLDGFRLDEIAPLAQGLEGKVENPQAVMREVLAWTGGQPLLTQKVCNLLIQDLRNPTPTLARRGEIGGNEWVEGVVRSGIIENWESQDEQEHLKTIRDRLLVNEQIAVALLGLYQQILQKGEIAVDGSFEQMRSRLTGLVVQQQGKLRVYNQIYGNVFDLIWVENELGKLRFYADKLRAWVESNYQDNTCLLWGEDLEKSRVWADGRKLSDVDYRFLSASLEAELNQKVAEAEGKQNQAFEEERKANKRLAEVERKTNQKIRNGLIVLTLSVFGVITALIFASSAEQRRSVATSQFNSTNSELDSKKIELSKAKESIKTLTRQQEEREKLIAIANSEKKQAETAKKQLEIKSKQANYKLNATNTKLQTANQQVKAAQQLFSEANNKVQSAEEEAKNAKGEQKNANNLAQQARNELASAKKGLEEAQKKQQEAEKQAQIAEKQQKEAQQLLAKAKVDLEIASRGVEKLNIAVVDIQQKIGESRALARNLTNTGEVYNSIGETEQALKLFNEALPIQREIRDYIGQGRTLSKIGTIYSYIGEPKKALEFFNQALPLQRTALDRAGEATTLDNIGAVYQTLGERQKALEFFNKALSLRREVGDKAGEATTLDNVGSVYQALGESQKALQFFNQALPLRREVGDKAGEATTLDNIGTVYQTLGNPQKALEFFNQALSLRRAASNRVGEANTLKNIANLERSRGNLNKSLTQLKTAININEDLSKNFINPELRAYYFSSVQDNYELYTDLLMQMHVQQPSKGYDAQALSANERSRAMSFMEFLTESNSNIRQGANPELLARERSLQQEISALETQRLELSSRRDTEKQVTETSQKITSLLEDYKQLQTKIRISSPRYAALKYPKTLSLQEIQQQVLDNNTLLVAYSLGKERSYLWAVSKTSITSYQLPKRSDIEVATSNFRYSLGQPNTAANFAQEDGKKLSSIILSPVANQLQQKRLLITADGILQTIPFAALPIPNNNEQDFTPLLVQNEIVNAPSASSIAVLRNQLKGRIPAPKTVAVIADPVFTSDDPRLTGKRPEIAPQLDLQFTGKRPEIAPQLDLQFTHSGFARLPFTREEAEEILRLVPENKRFSAFDFAANYETVTSPKLAKYQIMHFATHAFVDSQNLELSGLVLSQFDSKGNPKPSYLRLFDIFNLNLSAELVVLSSSDTGLGKEVKGQGIVGLTRGFMYAGSPRVISSLWQVSDQGTSVLMARFYRKMLVDGLKPSAALRAAQLDMLKEEKWRNPFYWAAFTMQGEWR
>NC_019751.1|WP_015197063.1|1576717_1577116_+|PIN-domain-containing-protein
MKYVIDTHALIWFLEGNPRLGTNAKAILSHPDSRLIIPATALAEAVWIVERGRTCIPSAKDVISAVEADSRVIIYPLDKDVIEITINLSAINEMHDRQIVATVIFLANKGEEVQLLSCDKNIVESGLVPITW
>NC_019751.1|WP_083866295.1|1591936_1594270_-|hypothetical-protein
MISSPHYSVDSGFSGKLDQRNQEVAQRRQQVETLKKSVESLKKSATRSQGDREKAQQAAQQAQTKLKEAEKSLEIAVNQLEETKQEQQVALRERQVALQERKIAIEQSQQAKQQNQEAKKQAQTAETQREEAEQQRKNALTATRLEQVGIRTLRQFYVGGQIENLLEIMRAGRELKGLVKSKQSLADYPAYSPVFSLQEILLNIREWNQLEGHNKVNSVAFSPDRKMLAVGSDGSIKLWNLTTGKEIASLTTGNKSEINSVMFSPDGTTLASASEDTTIKLWNVAKGKEITSLTGHEESVQSVVFSPDGTTLASGSKDTTIKLWNVAKGKEITSLTGHEESVQSVVFSPDGKTLASASWDKTIKLWNVATGKKIASLTGHQINVDSVAFSLDGTTLASASSDGSIKLWNLATGKEIASLTGHEESVQSVVFSPDGKTLASASWDKTIKLWNVLTGKDIPSLTGHQDYVYSVAFSPDGKMLASGSGDSTIKLWNVLTGKEITSLIGHQTRVESVVFSPDGKTLASASLDNSIKLWNVATGKETVSLTGHRQTVESVVFSPDGKTLASASSDKTIKLWNVATGKETASLTGHQETVGSVVFSPDGKTLASASVDKTIKLWNVTTGKETASLAGHQGYVYSVAFSPDGKTLASGSRDKTIKLWNVTTGKEIYSLTGHQEGGRSVTFSPDGKTLASASWDKTIKLWNVATGKEIASLTGHQDWVSSVVFSPDGKTLASGSGDKTIKLWSLDLDDLLAQGCNYLKDYLATRDELRQEICPNK
>NC_019751.1|WP_083866360.1|1594404_1594620_-|hypothetical-protein
MNNHLKATKLNIGGTNISSPHKKPRNRELTAEQKDENKVFSSNRVFVEHIIRVIKIFRVASERFRLHSNTY
>NC_019751.1|WP_144051010.1|1594866_1595103_-|hypothetical-protein
MLPHQGFYIPLHSLNIYSQLCSKCDRIISVILSDRLTSYCQRGMTPKNCYAKWEVNHEAIADENGITGKELFDQLVQF
>NC_019751.1|WP_015173935.1|1596394_1598062_-|IS1634-family-transposase
MSPTSIAEIKNIDHLGIVAGLIDEIGIVETINSKLGVDSREKITAGVLVKAVLINGLGFVSRPLYLFKQFFDDKAIELLLGEGVESNYLNDDKIGRVMDDLYKYGLNNLFIEIVLSVIKKFKIDTKYSHLDATSFHLHGKYKREMNQEKEEEITKERPIFITKGYSRDHRPDLKQCVLDLITSSDGDIPLLMRAGDGNEADKAVFGKILIEFKKQIVFDSIMVCDSALYSQENLKLIENLKWISRVPMTIKKAQELVQSVNTEEMEEIEEIETEEKEIETEEKKKKTYQDLDGYKWKEEIVNYGGIKQIWLIVESQKRKDSDLEKLDKKLIKEKDKVEKLLKELKREDFETPEQARYKLKGINKKLKFHEIKEANFIESKSKNNKTIYKMEGVSYEKPEEIEIQRKEAGRFILATNLVNDDDKLKPEEIITTYKNQQSCERGFRFLKDPLFFADSFFLENPERIETMLFLMSLCLLVYNLGQRELRNSLKRIKIGIKNQLGKLTLSPTLRWVFQCFQGIHFLMLDGLNQIVNLTSERHFILSCLPSSCQKYYLLS
>NC_019751.1|WP_015197074.1|1600749_1601781_+|CHAT-domain-containing-protein
MKKILILSANPKNTPNLRLDEEVREIKNTLQLSPNRDGFQIITESAVRVDDLTRFLSHHQPTIVHFSGHGSGTDGLALEDNSGHMQLVSTQALAKLFDLFQLQVECVLLNACYSESQATAIHQYIDCVVGMNQAIGDKAAIEFSVGFYTALAAGRNYEDCFHMGCTSIDLQGIPEYLTPMRKIRQRRYQTVQAANPVTSNKDDSINNDNKGWQNRSVSIVGNVPGSAIQTGDSNTANINFQQVSLPAPASVNIETELNALREILAKLETSDRRKIDNAIADAEEEINKPQPDKNEVGKALERAFDYAKKAEGFASVIEKLKPHLTKTVGWLGENWHKLLSLVN
>NC_019751.1|WP_015197075.1|1601871_1603350_-|SAM-dependent-DNA-methyltransferase
MANESSTIVQKLWNYCNVLRDDGVSYSDYVEQLTYLLFLKMVEEQNQLPPPLGKRSTIPTEYSWEALRSQDGDALEIQYRHTLENLGKEKGLLGVIFRKSQNKIQDPAKLKRLVELINSETWIGLDIDVKGEIYEGLLQKNAEDVKGGAGQYFTPRALIKAIVEVMEPQPGQRICDPACGTGGFFLVANDTIIKNYKLDKAQKLFLKNQTFKGFDVADGVVRLCAMNLYLHGIAGDESPVEAKDSLMADPGDRFELVLTNPPFGKKSSITVFNDDGKADKEKIVYRRDDFWATTSNKQLNFLQHVKTLLQINGKAAVVVPDNVLFEGGAGETIRKKLLHECDVHTLLRLPTGIFYAQGVKANVLFFDRKPASADPWTKKLWIYDFRTNQHFTLKTNPIRYENLQDFIQCYSAEKRQERQETERFRAFSYEELMQRDKVSLDIFWLRDESLEDSDNLPAPDVLALEIAEDLGAALELFQSITENLEAKTVIEV
>NC_019751.1|WP_015197076.1|1603673_1608128_+|NACHT-domain-containing-protein
MSLINLDLVFNAITSIANPLIKEKLLRSETVIKLLQQFNLDPEHPPADFSGVYAYALVEYGVGKPKPLLELFRQEAIKQAFRTALDHNNPSILLSEVDVFLDAYTLGDDIRGLGLDVRREVAEFATVFIEVAKRTRTPADVLLNQKIGSLHKRIATIQEQLERLPTLEGIRTEIARLAVENYPALPGSVTENQCRAIALAQQMRGWFETLGYDFEKYEIWAEEYFEWIIQIPVRRSYDRILIRGVAGEIGLSDVMALRSSVEAQKTDEGWLVTTRRISRAARDEVKKEENHRLDCFTFDELIDLDADFNAYLDWLEAEIKRRKIDTKYVPLACTKEEIHPVTKQRIGVSRYEEEDGWIDGYIDLWLDDPAKEHISILGEFGTGKTWFVFHYAWIALQRYRDAQKRGVERPRLPLVITLRDFAKALNVENVLAGFFFTQHNIRINSEVFDQLNRMGKLLLIFDGFDEMAAKVDRQQMINNFWELAKVVVPGAKVILTCRTEHFPEAKEGRALLNAELQASTKKLTGETPQFEVLELEKFNDEQIRQVLSYQAEAATVEQVMGNEQLLDLARRPVMTDLILEALPDIEAGKPVDMSRVYLYAVRRKMERDIKAERTFTSLADKLYFLCELSWEMLSNDQMSLNYRLFPERIRRLFGSSVQEEKDLDHWHYDMMAQTMLVRNADGDYTPAHRSLLEFFVAYKFAAELGALASDFTELAQARSLVDKTVAPADYTWSGYFSQQGSGEAMPAANPLGNASLREFKSESLDKLRETFGKVPLTKAVMDLLLPMLGNNELLISVIKETRDKNEDEVGYIGGNAATLAVKIDKAVLEGRDLSRAVIKAADFSNASLRDVNFTEANLIDSGFVKDFGAVFSVAYSSDGQFLATGDGNGIVRLWKVSTSREILTCKGHTSGILSVNFSSDAYTFASGGYDGTIKLWNSQNGKCLKTLEGHNYSVNSVVFCSEGKILASGSSDNTIRLWDITTGQCLQILEGHTDSILSIALSTDDKILASGASDNTVRLWNTQTGKCLKILQGHTNSVSSVVFSPDGQLLASAGYDATLKLWEIQTGQCKSTLETPNNPIFAITFSPDSKILASSSNQIIKLWDISTNKCIQILEGHFNIVRSIAFSPKGNNLVSGSYDKTVRFWNISTGECFKILQGYSNWVNSITFSLDSQKLASGDDLAIVIWDVSSGKSLRTLQGHTHWVQSIALNQDGTILASGSADNTVRLWDFQTGECLKLLQGHSDWVQSVAFSPDNQLLASGSADGTVRLWEVPVGRCWKILRSNYSIRSVAFSLDGEILASGLSDGTLQLWNIHTSECLKTLQVGNNIGTRSIAFSPDSKVLASGISNASVGLWNISTGEFLRSLQAHTDSVLAVAFSPDSKILASSGDDQTVILWDINSGECLKILRGHSLWIRSVAFSSDGNIIASCSCDSTIKLWNVETGECLKTLINKRPYENMTITGVRGLTEAEKASLKALGAVEDGE
>NC_019751.1|WP_015197077.1|1608237_1609512_-|hypothetical-protein
MIKRLFPVPNHLGEQLPILTEDKKQVLQQQTITQNSPGTILRDFQTILEFLQPDGVEVSSTYHQFSLKYLQELNSRLSYPIETNLKRPQQKSYPYIYGLYFVLRTSGLSQVITQGKKTKLVLDEQLLKIWQGFNPTEQYFTLLESWLIWGESEVLGEPRDPFGLLFRCCQFWREIPDEGLNINSYSEQDKLVYYPGLHSLSLFHLFGFLELIPGKPEPAKGWRIAAVKRRPWGDAMIALISEIYDEIEPDREEEEITLNFRIAFEKLKPSLQIYFPEWEQTLVIAKGEFTDAIYTFKVTLLDAWRRIAIPSNFNFDQVAAAFVQAFDFDFEHLYRFIYKDHLGRTFEFSHPFVDIPPNTSDFRLGELPLKTGNHLQFIFDLLDEWEFDLLLEKIEPANAKMKQPKILEIHGEAPTQYGEEEEVY
>NC_019751.1|WP_051036615.1|1609504_1610074_-|hypothetical-protein
MGDFIFGKIGTLGKPVKISQPFNYTLSANVVLVQPDINFLNPEFAITYMASPLIETLLKKESRATTQSAFGIQKVRIIPFPLPPSQEQLAIAEEIELIFSVTDKLEKTINVNLKRAEKLRQTILKQAFEGKLVPQDPNDEPAEKLLERIKAEKAQREADKKPKRQSTIKSKQPRKSKTTATQLELKLDD
>NC_019751.1|WP_015197078.1|1611664_1612666_-|restriction-endonuclease-subunit-S
MGEELYELPKGWAYSELRDVAEIIMGQSPPGDSYNQDGIGVPLINGPVEFGPRPFSKTIRSKFTTQPTRMCKKDDLILCVRGSTTGRINIAGFDASIGRGVAAIRSLLYQEYLNIFIHAIREQIYNRGTGSTFPNVSNEAVSSIIVPLPPLPEQHRIVAKIEELFTQLDTGVELLKKVKAKLKRYRQAVLKAAVEGNLTKEWREANQGELEPASVLLERILKQRREKWEAEQLAKMKAQGKTPKDDSWKLKYQEPVAPDTSELRELPDEWVWTTLELVANAVDPQPSHRTPPTVDGGVPYIGMGDIKDGKIDFENSRKVSIEVLKEHQGTSKE

Crispr_ID: NC_019751_6

• CRISPR_ID: NC_019751_6
• CRISPR_location: 1621155-1621703
• CRISPR_type: TypeV-U5
• Repeat_type: V-U5
• Spacer_info: 7 spacers
• Cas_protein_info: c2c5_V-U5

Consensus repeat of NC_019751_6

Consensus_repeat	Method
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	PILER-CR
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	CRISPRCasFinder
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	CRT

spacers of NC_019751_6

>6.1|1621192|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
GTATCAAATTCGACTCTAATGGTTATCAAGTGATTG
>6.2|1621265|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CCTAAGTCTGGGCGGGTTGATATTCCTACTGATT
>6.3|1621336|37|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TTAACGTTGGATATATTGGAGATTTTTGCACTGCCGT
>6.4|1621410|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TCGTCTTTAATTTTTTCTAGGGAAACTTGAAACTC
>6.5|1621482|40|NC_019751|PILER-CR,CRISPRCasFinder,CRT
AAGCCTAGCTTTGTAGGAGCAAAAAATGAACCAACATGAA
>6.6|1621559|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CTGCAACCGCAAATATTCGTCCTCATATAACACTA
>6.7|1621631|36|NC_019751|CRISPRCasFinder,CRT
ACGGTTAGACTTGCTTGGATACGTTAGCGATCGCAT

CRISPR arrays and Neighbor proteins around NC_019751_6

CRISPR arrays

The CRISPR arrays of NC_019751_6

>merge|NC_019751|6|1621155-1621703|PILER-CR,CRISPRCasFinder,CRT
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAGGTATCAAATTCGACTCTAATGGTTATCAAGTGATTGGTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAGCCTAAGTCTGGGCGGGTTGATATTCCTACTGATTGTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAGTTAACGTTGGATATATTGGAGATTTTTGCACTGCCGTGTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAGTCGTCTTTAATTTTTTCTAGGGAAACTTGAAACTCGTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAGAAGCCTAGCTTTGTAGGAGCAAAAAATGAACCAACATGAAGTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAGCTGCAACCGCAAATATTCGTCCTCATATAACACTAGTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAGACGGTTAGACTTGCTTGGATACGTTAGCGATCGCATGTTTCGACAGCCATTCCGTCTAGGGATGGGTTGAAAG

>NC_019751|6|4|1621155-1621630|PILER-CR
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	GTATCAAATTCGACTCTAATGGTTATCAAGTGATTG
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	CCTAAGTCTGGGCGGGTTGATATTCCTACTGATT
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	TTAACGTTGGATATATTGGAGATTTTTGCACTGCCGT
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	TCGTCTTTAATTTTTTCTAGGGAAACTTGAAACTC
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	AAGCCTAGCTTTGTAGGAGCAAAAAATGAACCAACATGAA
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	CTGCAACCGCAAATATTCGTCCTCATATAACACTA
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG

>NC_019751|6|6|1621155-1621703|CRISPRCasFinder
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	GTATCAAATTCGACTCTAATGGTTATCAAGTGATTG
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	CCTAAGTCTGGGCGGGTTGATATTCCTACTGATT
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	TTAACGTTGGATATATTGGAGATTTTTGCACTGCCGT
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	TCGTCTTTAATTTTTTCTAGGGAAACTTGAAACTC
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	AAGCCTAGCTTTGTAGGAGCAAAAAATGAACCAACATGAA
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	CTGCAACCGCAAATATTCGTCCTCATATAACACTA
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	ACGGTTAGACTTGCTTGGATACGTTAGCGATCGCAT
GTTTCGACAGCCATTCCGTCTAGGGATGGGTTGAAAG

>NC_019751|6|4|1621155-1621703|CRT
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	GTATCAAATTCGACTCTAATGGTTATCAAGTGATTG
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	CCTAAGTCTGGGCGGGTTGATATTCCTACTGATT
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	TTAACGTTGGATATATTGGAGATTTTTGCACTGCCGT
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	TCGTCTTTAATTTTTTCTAGGGAAACTTGAAACTC
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	AAGCCTAGCTTTGTAGGAGCAAAAAATGAACCAACATGAA
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	CTGCAACCGCAAATATTCGTCCTCATATAACACTA
GTTTCAACTACCATCCCGACTAGGGGTGGGTTGAAAG	ACGGTTAGACTTGCTTGGATACGTTAGCGATCGCAT
GTTTCGACAGCCATTCCGTCTAGGGATGGGTTGAAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015197095.1|1633906_1634104_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_041739177.1|1629290_1629830_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197091.1|1628665_1629091_+|TerB-family-tellurite-resistance-protein	unknown	unknown	gnl|CDD|143581
NC_019751.1|WP_015197084.1|1618647_1620567_+|hypothetical-protein	c2c5_V-U5	-	unknown
NC_019751.1|WP_015197086.1|1622561_1624004_+|neutral-invertase	unknown	unknown	gnl|CDD|372373
NC_019751.1|WP_015197082.1|1616465_1618334_+|DUF262-domain-containing-protein	unknown	unknown	gnl|CDD|226003
NC_019751.1|WP_015197087.1|1624384_1625818_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_041739172.1|1615603_1615897_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197088.1|1625927_1627082_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_158333134.1|1620870_1621035_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_051036615.1|1609504_1610074_-|hypothetical-protein	unknown	unknown	gnl|CDD|341135
NC_019751.1|WP_015197090.1|1627258_1628605_+|16S-rRNA-(cytosine(967)-C(5))-methyltransferase	unknown	unknown	gnl|CDD|237856
NC_019751.1|WP_015197094.1|1632614_1633688_+|HEAT-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NC_019751.1|WP_015197083.1|1618338_1618557_-|hypothetical-protein	unknown	unknown	gnl|CDD|222824
NC_019751.1|WP_015197078.1|1611664_1612666_-|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341187
NC_019751.1|WP_015197079.1|1612665_1615401_-|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl|CDD|226581
NC_019751.1|WP_015197081.1|1616053_1616368_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197093.1|1630681_1632076_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197077.1|1608237_1609512_-|hypothetical-protein	unknown	unknown	gnl|CDD|377943
NC_019751.1|WP_015197096.1|1634312_1635482_-|ribulose-bisphosphate-carboxylase	unknown	unknown	gnl|CDD|173974

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_019751.1|WP_015197084.1|1618647_1620567_+|hypothetical-protein	c2c5_V-U5	-	1.1e-294	973.3	30.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015197096.1|1634312_1635482_-|ribulose-bisphosphate-carboxylase	gnl|CDD|173974	cd08209, RLP_DK-MTP-1-P-enolase, 2,3-diketo-5-methylthiopentyl-1-phosphate enolase. Ribulose bisphosphate carboxylase like proteins (RLPs) similar to B. subtilis YkrW protein, have been identified as 2,3-diketo-5-methylthiopentyl-1-phosphate enolases. They catalyze the tautomerization of 2,3-diketo-5-methylthiopentane 1-phosphate (DK-MTP 1-P). This is an important step in the methionine salvage pathway in which 5-methylthio-D-ribose (MTR) derived from 5'-methylthioadenosine is converted to methionine.	0
NC_019751.1|WP_015197090.1|1627258_1628605_+|16S-rRNA-(cytosine(967)-C(5))-methyltransferase	gnl|CDD|237856	PRK14901, PRK14901, 16S rRNA methyltransferase B; Provisional.	0
NC_019751.1|WP_015197094.1|1632614_1633688_+|HEAT-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	2.88239e-17
NC_019751.1|WP_015197083.1|1618338_1618557_-|hypothetical-protein	gnl|CDD|222824	PHA01623, PHA01623, hypothetical protein.	0.00983569
NC_019751.1|WP_015197078.1|1611664_1612666_-|restriction-endonuclease-subunit-S	gnl|CDD|341187	cd17496, RMtype1_S_BliBORF2384P-TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Bacillus licheniformis S subunit (S1.BliBORF2384P) TRD1-CR1 and Chlorobium tepidum TLS S subunit (S.CteTORF675P) TRD1-CR1. The recognition sequences for Bacillus licheniformis S subunit (S1.BliBORF2384P) and Chlorobium tepidum TLS S subunit (S.CteTORF675P) are undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. This subfamily of TRD-CR's shows similarity to TRD1-CR1 of Aminobacterium colombiense DSM 12261 S subunit (S.Aco12261I), which recognizes 5'... GCANNNNNNTGT ... 3'. This subfamily may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	3.26311e-82
NC_019751.1|WP_015197082.1|1616465_1618334_+|DUF262-domain-containing-protein	gnl|CDD|226003	COG3472, COG3472, Uncharacterized conserved protein [Function unknown].	1.95055e-121
NC_019751.1|WP_015197079.1|1612665_1615401_-|DEAD/DEAH-box-helicase-family-protein	gnl|CDD|226581	COG4096, HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	1.08047e-143
NC_019751.1|WP_015197077.1|1608237_1609512_-|hypothetical-protein	gnl|CDD|377943	pfam07929, PRiA4_ORF3, Plasmid pRiA4b ORF-3-like protein. Members of this family are similar to the protein product of ORF-3 found on plasmid pRiA4 in the bacterium Agrobacterium rhizogenes. This plasmid is responsible for tumorigenesis at wound sites of plants infected by this bacterium, but the ORF-3 product does not seem to be involved in the pathogenetic process. Other proteins found in this family are annotated as being putative TnpR resolvases, but no further evidence was found to back this. Moreover, another member of this family is described as a probable lexA repressor and in fact carries a LexA DNA binding domain (pfam01726), but no references were found to expand on this.	2.72635e-16
NC_019751.1|WP_015197091.1|1628665_1629091_+|TerB-family-tellurite-resistance-protein	gnl|CDD|143581	cd07177, terB_like, tellurium resistance terB-like protein. This family consists of tellurium resistance terB proteins, N-terminal domain of heat shock DnaJ-like proteins, N-terminal domain of Mo-dependent nitrogenase-like proteins, C-terminal domain of ABC transporter ATP-binding proteins, C-terminal domain of serine/threonine protein kinase, and many hypothetical bacterial proteins. The function of this family is unknown.	9.63543e-12
NC_019751.1|WP_051036615.1|1609504_1610074_-|hypothetical-protein	gnl|CDD|341135	cd17246, RMtype1_S_SonII-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Shewanella oneidensis MR-1 S subunit (S.SonII) TRD2-CR2. This model contains Shewanella oneidensis MR-1 S subunit (S.SonII) TRD2-CR2 and similar TRD-CR's. S.SonII recognizes 5'... GTCANNNNNNRTCA ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases. S.SonII TRD1-CR1 does not belong to this subfamily.	6.44307e-21
NC_019751.1|WP_015197086.1|1622561_1624004_+|neutral-invertase	gnl|CDD|372373	pfam12899, Glyco_hydro_100, Alkaline and neutral invertase. This is a family of bacterial and plant alkaline and neutral invertases, EC:3.2.1.26, previously known as Invertase_neut pfam04853.	0

Protein sequences

>NC_019751.1|WP_158333134.1|1620870_1621035_+|hypothetical-protein
MQIWSRFITVGITSAVVTESPPSSGEPSQIFFWRVEAGAKSLDSRQNLKTLALY
>NC_019751.1|WP_015197084.1|1618647_1620567_+|hypothetical-protein
MSVITIQCRLVADEETLRHLWTLMAEKNTPFANEILEQLAQHAEFESWVKNSRVPATVIKELCDSLKNQELFAGQPGRFYTSATTLVTYIYKSWLAVNKRLQRKIEGKKQWLDMLRSDTELEQESNSNLEKIRAKATEILDSFATRQINQVNSKSKTSKNNKNKQEKEVKSLSIQSNILFETYRQTEDNLTKCAIVYLLKNNCEVNDVEEDIEEYEKNKRKKEIQIKRLEDQLKSRVPKGRDLTGEKWVEVLEKAVNSVPESENEAKSWQASLLRKSSQIPFPVVYETNEDIKWSINEKGRIFVSFNGLGKLKFEIFCDKRHLHYFQRFLEDQDIKRQGKNQHSSSLFTLRSGRISWLEQPGKGKPWNINRLLLFCSIDTRMLTAEGTQQVIEEKIADTQNKIAKAQEKCEGELNPNQQAHINRKKSTLARINTPFPRPSKPLYQGKSHIVVGVSLGLKATATIAVFDAMNNQVLAYRSTKQLLGDNYKLLNRQQQQKQRLSQQRHKSQKQFASNSFGESELGQYVDRLLAKEIVAVAKNFGAGSIVLPKLGDMREIIQSEVQAKAEKKIPGFIELQKNYAKEYRKSAHNWSYGRLIENIQSQATKEGIEIETGKQPTRGIPQEQARDLALFAYQCRIA
>NC_019751.1|WP_015197083.1|1618338_1618557_-|hypothetical-protein
MLVYYARINPGRAFGAGMTEETREVRGRIPKELKITFEIACARLEVTQTAALEEAIKDWLKKQESTSSDKSV
>NC_019751.1|WP_015197082.1|1616465_1618334_+|DUF262-domain-containing-protein
MIVTAEPPMDSISTFDITKYPLFDVMKDIKIGRIQLPDFQRDWVWDDTHVRRLLASISLAYPIGAVMMLQQGIQRQQFKPRLVDGVTNKAAQTPNLLVLDGQQRLTTLFMVLLSKQPVIIKDPRSQKLVKKWYYLNIEKSLEPEVDRKSTIIALPETKVMRTRNGDCIDCSTPENEYEALLFPLSKVFFFSEWRSKFSKYWQYDPQKLQLIDTLELEVLKKFEHYQIPVIQLRDSLPKEAVCQVFEDTNTAGCDLNFFDLMSSSYCVNDFSLRDDWKQRETRFQSFKVLRKVRNTDFIQSVTLVAGYARRREAIKQGWNLDKLPAVSCGRSEVLKLTKEEYQTWADPVHRGFEEAARFLHGQKIFDADDIAYPIQLVALSAILTIVGERSRSFQVRSKLERWLWCGMFGEIYTHWHDGQAGRDAVEVPAWINGGAVPFSITQANFSYERLLSVRKRLGAVYQGFAALLRREGAVDWITGEEINDVVYFEEQIDSHHIFPVAWCRKQGIDPTMYNCLVNRTPLSAKTNKRIGSKPPSVYLKEFEQYGTAVANLEEIMRSHCIELSILQCDNFETFFQARATALMELIGKAMGKDLSIKLHGNSDRDYLNHNGCKLHPETITTS
>NC_019751.1|WP_015197081.1|1616053_1616368_+|hypothetical-protein
MQTGSKSQQNKHRIDSLCQLPLEPMEYCRRWVVHEPGRNYRKSCINAIAQVTGTSPKTVKDWGKDFRYRPKYVTRILRQADLINQFKQLVAQGIINLPPDSLQE
>NC_019751.1|WP_041739172.1|1615603_1615897_+|hypothetical-protein
MDSDRKTPQYRIDALGNLPLEPLEYCRKWVDMSPDERGYRKACVIALAEATGLSERTIGNWGTNFEKRPNYVAHILRMADKLNQIKKIVLPPDFPQE
>NC_019751.1|WP_015197079.1|1612665_1615401_-|DEAD/DEAH-box-helicase-family-protein
MKPEEKTRIEIDKLLTAAGWIVQDHKDINLGAGIGIAVREYPLKLGVADYLLFINRNAAGVIEAKAEGSTLSGVEIQSDKYIFNLPSNLRCHRKPLPFAYESTGKETFFRDSRESDYRSRRIFAFHKPETLQEWLQESDTLRERLKQLPEIDTEDLRDCQKDAIAGLFNSFAQNRPRALIQMATGVGKTYTAVSFIYWLIKLARARRVLFLVDRKNLGEQTQKEFQQYITPDDGRKFTELYNVQLLTSNNFDPVSKVCITTIQRVYSMLRGEAEFDVAEEEESLFDRDEENQQPKEVVYSSRIPIETFDFIITDECHRSIYNVWRQTLEYFDAFLVGLTATPSLQTFGFFNQNLVMEYRHEDAVADGVNVGYEVYRIRTQITEQGSTVEAGYHIDRRNRKTRAVRWQELDNDLTYTSNQLDRSVVAIDQIRTVIRTFRDRLFTEIFPGRREVPKTLIFAKDDSHAEDIVRIVREEFGKGNEFCKKITYRTTGEKTENLIASFRNSYNPRIAVTVDMISTGTDIKPLECLLFMRNVKSRTYFEQMKGRGTRTINYTDFQAVTPDAGVKEQFIIVDAVGVCEADKTDSRPLERKRSVTFDKLLQAIALDQRDEDTLMSLAGRLARLDQKLTPSDRTQLESFTGGKSMRQITKDILTALDLDNQIAKAEETFKTENPTEQQQEAAAEELINQACEPFDNPQFRQLLDEIYESKKDNDQIIDVVSQDKVLQAGFDTTARDKVMGTVESFQEFVAAKKDEITALQILYNQPYGQRRLTYEQIKQLANALERPPCNLTTEKLWQAYAQLQADKVRGAGVQKLLTDIISLVRFAMGETETLEPYAVTVEEKFQQWLATKEFTSQQVGWLEKIKEHIATSMRIEPEDLQEMPQEAFQGYQLFGNDLMDILDELNEALAA
>NC_019751.1|WP_015197078.1|1611664_1612666_-|restriction-endonuclease-subunit-S
MGEELYELPKGWAYSELRDVAEIIMGQSPPGDSYNQDGIGVPLINGPVEFGPRPFSKTIRSKFTTQPTRMCKKDDLILCVRGSTTGRINIAGFDASIGRGVAAIRSLLYQEYLNIFIHAIREQIYNRGTGSTFPNVSNEAVSSIIVPLPPLPEQHRIVAKIEELFTQLDTGVELLKKVKAKLKRYRQAVLKAAVEGNLTKEWREANQGELEPASVLLERILKQRREKWEAEQLAKMKAQGKTPKDDSWKLKYQEPVAPDTSELRELPDEWVWTTLELVANAVDPQPSHRTPPTVDGGVPYIGMGDIKDGKIDFENSRKVSIEVLKEHQGTSKE
>NC_019751.1|WP_051036615.1|1609504_1610074_-|hypothetical-protein
MGDFIFGKIGTLGKPVKISQPFNYTLSANVVLVQPDINFLNPEFAITYMASPLIETLLKKESRATTQSAFGIQKVRIIPFPLPPSQEQLAIAEEIELIFSVTDKLEKTINVNLKRAEKLRQTILKQAFEGKLVPQDPNDEPAEKLLERIKAEKAQREADKKPKRQSTIKSKQPRKSKTTATQLELKLDD
>NC_019751.1|WP_015197077.1|1608237_1609512_-|hypothetical-protein
MIKRLFPVPNHLGEQLPILTEDKKQVLQQQTITQNSPGTILRDFQTILEFLQPDGVEVSSTYHQFSLKYLQELNSRLSYPIETNLKRPQQKSYPYIYGLYFVLRTSGLSQVITQGKKTKLVLDEQLLKIWQGFNPTEQYFTLLESWLIWGESEVLGEPRDPFGLLFRCCQFWREIPDEGLNINSYSEQDKLVYYPGLHSLSLFHLFGFLELIPGKPEPAKGWRIAAVKRRPWGDAMIALISEIYDEIEPDREEEEITLNFRIAFEKLKPSLQIYFPEWEQTLVIAKGEFTDAIYTFKVTLLDAWRRIAIPSNFNFDQVAAAFVQAFDFDFEHLYRFIYKDHLGRTFEFSHPFVDIPPNTSDFRLGELPLKTGNHLQFIFDLLDEWEFDLLLEKIEPANAKMKQPKILEIHGEAPTQYGEEEEVY
>NC_019751.1|WP_015197086.1|1622561_1624004_+|neutral-invertase
MPRDESIDNMMEQQAWDALEKSIVYYKGRPVGTLAAYDPSVDALNYDQVFVRDFVSSGLIFLSKGKPEIVRNFLKETLKLQPKERQLDAYKPARGLMPASFKVISIDGEEFLEADFGEHAIARVTPVDSCLWWIILLRAYVVSTKDICFAHHPEFQNGIKLILELCLANRFDMYPTLLVPDGACMIDRRMGIFGHPLEIQSLFYAALRAAKELLVCQANPNIIEAIDNRLPLLCAHIRQHYWIDIHRLNAIYRFKSEEYGKTAVNLFNIYADSLPYYELDKWLPVKGGYLAGNVGPSQLDTRFFSLGNLMAIISELATEEQSQAIMNLIEERWDNLVGDMPMKICFPALQGEEYRIVTGCDPKNIPWSYHNAGSWPVLMWMLAAAAMKTNRVHLAEKAINIAESRLQEDEYPEYYDGKKGRLMGKQARKYQTWTITGYLLAKELVKNPSHLPLVSFEKLPQELVSRACEFEIDTVDVTLY
>NC_019751.1|WP_015197087.1|1624384_1625818_+|hypothetical-protein
MEKIESRTEQVVQEDLVMFINACYSCTGQREFYDEANGQKLSISFLHDYILGNYRLLYARTLAIGINHFNQAQIILKLLATGKNINPEYRQEEGGLIAEALNKLPPQRAWGLLQELQNKRINNRRTRAIVRDFIATRRDVNFDAVKYRTKVKAAISHTHLKLNNELPIFLFDYQQQKAFTTDLFENFRKAHYSQDAIYKLPFTIAEGFATKHKIKREIFLSRIQSQMTIGEKMRYQGAAERSDININVDWEHLPLTKLALYILSLPMETRIQTWEKFHRVLEELAKKVLKKSPLKLKLGRVAAVLDNSYSSSGSLEKRRRPLGIALATHYLLKAAATDYRAFWTLQPKNSLLVEPRGQTDLATPLLAALGCGAETVIIVSDGCENDPPKGATEVLRIYCTKLDRLRKTSIIHCNPVFNAEDYTLRSLSSHIPTVGLRDAEDLPTVLGFAKFAEGSLNLSELESYLAERVSSFLKHGF
>NC_019751.1|WP_015197088.1|1625927_1627082_+|hypothetical-protein
MLIKNILLKGLQIAPSQVCGSIRIVPLVRHKTRGDLHLQNRKYNDDLSIVSIDKNTNYYSYIPHGMVMSWSDDGSSVANMGINITKKDGKSFNNKYANVRLMHRMAKRESKNTLRFLPLHLAMEGFLSLYFNAPKIAWDEYSTYAKSYGLGCRTEYSVSGRAIFGLEEALRVFEIHEGQVGVLVYVAEALASAFVVPNPQDYRALHYNLLEDFYGDLIYRYALMYDQTYSMDLSIDASKISNLADLRSAVVQMRKDWASFNQGMMLDGLLDRQIHSRLVYTAGCFELQRFVTQVSLSDEENHIGEAIIRDNGELEYLHTYRLTAAQSRRVYYLRILDENNWNLKETATALACTQEEFVRKMEKEGFGYLFQQQIRDKARKANKR
>NC_019751.1|WP_015197090.1|1627258_1628605_+|16S-rRNA-(cytosine(967)-C(5))-methyltransferase
MLNPRQVAFFALRDVHKGAFVDVAIDRILNKSNLANLDRRLVTELVYGSVRRQRTLDAIIDKIAKKKSQQQPKDLRTILHLGLYQLRYQERIPDSAAVNTTVDLAKEHGFPGLTGLINGILRQYLRLIDAGDEIITSSNPVERLGILYSFPDWIIQVWVEQFGLEETEKLCQWMNQTPTIDLRVNLLRTTVEKVEAAFTAAGVKYQRLQYLPCGLRLLGHNGRIQDLPGFLDGWWTVQDSSAQLVGYLLDPKLNEVIIDTCAAPGGKTTHIAELMEDQGTIWACDRTASRMGKLKENIQRLQIQSIRTCVGDSRDLPQFTGIADKVLLDAPCSGLGTLHRHADARWRQTSANVQELAKLQTELISQTSKFVKPGGILVYATCTLHPQENEAVIASFLENHPNCQIEAPNPESPLAVHATPSGFIKVLPHNQDMDGFFMVRLRKTNNSG
>NC_019751.1|WP_015197091.1|1628665_1629091_+|TerB-family-tellurite-resistance-protein
MKSQSSSTKNLVKILIGAAWIDGKIQPEERQYLRHIAQEKGVATDPEIKPWLYELVSVQPNECYNWVREYLGEHPTNEDYQNLIQAISGLIYSDGEVAVEEAKLLTKLQQLSDENDVSQAGLNVILKQIQKLYRRWLEVQN
>NC_019751.1|WP_041739177.1|1629290_1629830_-|hypothetical-protein
MNADELNRFVAYCKRIQPQSQEDIRRFFEGVVGFPYDKELLLQAYLFLNIKDLFPCCSELLLFEKSPIADYTDLGKCDFVYLSSVGNLLLIETKFIDTEATGATERKRRNKHRNKVFEQVMTLKSRFSEYWDIRLEHLNCGVFTTDSEVEWRGSSVNVLTKAISIENLEQWRRSYKYGK
>NC_019751.1|WP_015197093.1|1630681_1632076_+|hypothetical-protein
MINQAAKKSLTNNFISIVELFNLLAANRQHIILNFHNLQENYQYQHIRQVIGTRDIDGNLIQPWLKAEDIDKNEYVQITSFSLNRHTASLNMLIQRQVRLINTQDATPITEVAGLLTNQLNRFNNYTVVSDGKFNIREIKVKISSKKTFELLHQSDIITDSEFDFRREYTINLDKFPIVDLEQPYQTIDGVFQKLAEAKVLVSIISAHLKQESDVFLAEQLDSLAQHHLSKQVYLNFPKTKESSESIQMRTIHKIDIGNKDILNLSKFHSANKFLNRMYCGYDIETGEVLKKLDFGMAILTNVAFQCKPISSRMKITEVDQFMKLIFDDFLGFSNCGIVTEILTRVGDRYLIQLLQEKRQGKHASKSEMVAALTAANTMLGQYIESIYREIISPLVFYIGSTGLLPKNMETTAMNSQQLAEKYPNLQFSPNEKHGKFFEVGDSIVSIYSQTELYSQKTDMTVLK
>NC_019751.1|WP_015197094.1|1632614_1633688_+|HEAT-domain-containing-protein
MNNLVKPKLTGLIKNLQNGDLTLRLDVIVTLSQMGKNAKNAVPALIAALSDSQLRYHIIIALGNIGIAANSAIPALIMTLQDVDEVIRAITIEALCKIGLEVDLIPSLVITLHDDSARVRANAAFAIGCLGEKAKLAIIPLVEILEDKDDWVRGNAVEALGKIGKDAEMAIPYLITALSDNYSGIRAKATLSLAYVAPENQAIPLLINMFGDSDARVRSAAADALGVFVNEVASVVIILKTGLTDKNIYVQMNVAKVLMKAGVEVENCLNIFVAALKQSDAIVRVTASLNIGVIAASIQDVINNFCLMDIEKIISVFEEVNLLISQVNLSCTKSVITSINSALQILNKSKTALKNRY
>NC_019751.1|WP_015197095.1|1633906_1634104_-|hypothetical-protein
MILIRDLVQKVLQAGYLSLEAEEQLRNLLQTKYDSEDLNAFMNLQQAAMSGFVKQQSREIRVKSQ
>NC_019751.1|WP_015197096.1|1634312_1635482_-|ribulose-bisphosphate-carboxylase
MSIEVDYRFPSGIDAEKQAKIIAVGQTAGTWDARFAHRQESLQAHLAEVVSVVKLDGGDSVATVRFPESNVENDIPSLLTMIFGKYSMAGAAKVVDLRLPENYGLRPKFGISGIRNQLEISQRPLIMAIFKPALGLSAQDHAEILQQVAQAGLDIIKDDEILGNIPTAPTFERLAACREVIDTVQQQTGRKLLYAVNVTGNATKLVENARKLVRAGANALLLNVFSYGFSVLEALAADPQVNVPIFTHPAGAGAISAAPNHGISYPITLGTLMAHAGADAVLYPAHYGSLPFDANEEMMIRDRLRSRNVMPVPSAGIHPGIVPQALADYGKDVILNAGTGIMDHPDGAAAGVEAFFAALERVQQGEPFDLASLPEGALRNAIQKWGATK

Crispr_ID: NC_019751_7

• CRISPR_ID: NC_019751_7
• CRISPR_location: 2021864-2022765
• CRISPR_type: TypeI-D
• Repeat_type: I-D,II-B
• Spacer_info: 12 spacers
• Cas_protein_info: cas3,PD-DExK,cas10d,csc2gr7,csc1gr5

Consensus repeat of NC_019751_7

Consensus_repeat	Method
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	PILER-CR
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CRISPRCasFinder
GTTCCTATAAACNAAAATCCCTATCAGGGATTGAAAC	CRT

spacers of NC_019751_7

>7.1|2021901|33|NC_019751|PILER-CR,CRISPRCasFinder,CRT
AGTTGCTTTTCCTGATAAAGATTGCCCGGAAAA
>7.2|2021971|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CTTACTCAGCAGGAAGATATCAGCAACTGAATGAC
>7.3|2022043|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CAACCCCTAAGAGTGAGCGCCAAAGAATTCTAGC
>7.4|2022114|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
AACGAAAATCTAGATGATTTTAGGGCTAATTTTGCT
>7.5|2022187|42|NC_019751|PILER-CR,CRISPRCasFinder,CRT
AGTTAGCGCAGAAACCAGGCAGCAAGCAATCAGGCAATTCTT
>7.6|2022266|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT
ATCTGGGCTATGACGAGTTAACTCATTTCACGAA
>7.7|2022337|33|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TCATAACGGTGCAACTTGGGGGATAAATAATGA
>7.8|2022407|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
AAAGAAGTATAAGTCTGAATAAGTCTGAATATCCCT
>7.9|2022480|37|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CCTTTGATTAGCTATCAACCTGGCGACAAGGCTGTAG
>7.10|2022554|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TTGATAATAGTATTCTGAATACTCTGGTGTAATT
>7.11|2022625|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
AGTAACCATTCGTTCGCGGAATCTTTACCCATACT
>7.12|2022697|32|NC_019751|CRISPRCasFinder,CRT
CCAGCACGAGTGCGATCGCCGATTGCGATCGC

CRISPR arrays and Neighbor proteins around NC_019751_7

CRISPR arrays

The CRISPR arrays of NC_019751_7

>merge|NC_019751|7|2021864-2022765|PILER-CR,CRISPRCasFinder,CRT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACAGTTGCTTTTCCTGATAAAGATTGCCCGGAAAAGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCTTACTCAGCAGGAAGATATCAGCAACTGAATGACGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCAACCCCTAAGAGTGAGCGCCAAAGAATTCTAGCGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACAACGAAAATCTAGATGATTTTAGGGCTAATTTTGCTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACAGTTAGCGCAGAAACCAGGCAGCAAGCAATCAGGCAATTCTTGTTCCTATAAACCAAAATCCCTATCAGGGATTGAAACATCTGGGCTATGACGAGTTAACTCATTTCACGAAGTTCCTATAAACCAAAATCCCTATCAGGGATTGAAACTCATAACGGTGCAACTTGGGGGATAAATAATGAGTTCCTATAAACCAAAATCCCTATCAGGGATTGAAACAAAGAAGTATAAGTCTGAATAAGTCTGAATATCCCTGTTCCTATAAACCAAAATCCCTATCAGGGATTGAAACCCTTTGATTAGCTATCAACCTGGCGACAAGGCTGTAGGTTCCTATAAACCAAAATCCCTATCAGGGATTGAAACTTGATAATAGTATTCTGAATACTCTGGTGTAATTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACAGTAACCATTCGTTCGCGGAATCTTTACCCATACTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCCAGCACGAGTGCGATCGCCGATTGCGATCGCGTTCCTATAAAGTAAAATTCCTAAGCCATATCGTATA

>NC_019751|7|5|2021864-2022696|PILER-CR
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGTTGCTTTTCCTGATAAAGATTGCCCGGAAAA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTTACTCAGCAGGAAGATATCAGCAACTGAATGAC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CAACCCCTAAGAGTGAGCGCCAAAGAATTCTAGC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AACGAAAATCTAGATGATTTTAGGGCTAATTTTGCT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGTTAGCGCAGAAACCAGGCAGCAAGCAATCAGGCAATTCTT
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	ATCTGGGCTATGACGAGTTAACTCATTTCACGAA
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	TCATAACGGTGCAACTTGGGGGATAAATAATGA
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	AAAGAAGTATAAGTCTGAATAAGTCTGAATATCCCT
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	CCTTTGATTAGCTATCAACCTGGCGACAAGGCTGTAG
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	TTGATAATAGTATTCTGAATACTCTGGTGTAATT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGTAACCATTCGTTCGCGGAATCTTTACCCATACT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC

>NC_019751|7|7|2021864-2022765|CRISPRCasFinder
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGTTGCTTTTCCTGATAAAGATTGCCCGGAAAA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTTACTCAGCAGGAAGATATCAGCAACTGAATGAC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CAACCCCTAAGAGTGAGCGCCAAAGAATTCTAGC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AACGAAAATCTAGATGATTTTAGGGCTAATTTTGCT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGTTAGCGCAGAAACCAGGCAGCAAGCAATCAGGCAATTCTT
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	ATCTGGGCTATGACGAGTTAACTCATTTCACGAA
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	TCATAACGGTGCAACTTGGGGGATAAATAATGA
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	AAAGAAGTATAAGTCTGAATAAGTCTGAATATCCCT
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	CCTTTGATTAGCTATCAACCTGGCGACAAGGCTGTAG
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	TTGATAATAGTATTCTGAATACTCTGGTGTAATT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGTAACCATTCGTTCGCGGAATCTTTACCCATACT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CCAGCACGAGTGCGATCGCCGATTGCGATCGC
GTTCCTATAAAGTAAAATTCCTAAGCCATATCGTATA

>NC_019751|7|5|2021864-2022765|CRT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGTTGCTTTTCCTGATAAAGATTGCCCGGAAAA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTTACTCAGCAGGAAGATATCAGCAACTGAATGAC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CAACCCCTAAGAGTGAGCGCCAAAGAATTCTAGC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AACGAAAATCTAGATGATTTTAGGGCTAATTTTGCT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGTTAGCGCAGAAACCAGGCAGCAAGCAATCAGGCAATTCTT
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	ATCTGGGCTATGACGAGTTAACTCATTTCACGAA
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	TCATAACGGTGCAACTTGGGGGATAAATAATGA
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	AAAGAAGTATAAGTCTGAATAAGTCTGAATATCCCT
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	CCTTTGATTAGCTATCAACCTGGCGACAAGGCTGTAG
GTTCCTATAAACCAAAATCCCTATCAGGGATTGAAAC	TTGATAATAGTATTCTGAATACTCTGGTGTAATT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGTAACCATTCGTTCGCGGAATCTTTACCCATACT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CCAGCACGAGTGCGATCGCCGATTGCGATCGC
GTTCCTATAAAGTAAAATTCCTAAGCCATATCGTATA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_041740352.1|2009215_2010940_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274311
NC_019751.1|WP_015197388.1|2027769_2028213_+|DUF86-domain-containing-protein	unknown	unknown	gnl|CDD|366864
NC_019751.1|WP_015197375.1|2000751_2002263_-|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|225857
NC_019751.1|WP_041739263.1|2004385_2009074_-|PfaB-family-protein	unknown	unknown	gnl|CDD|238429
NC_019751.1|WP_015197381.1|2017108_2018581_+|recombinase-family-protein	unknown	unknown	gnl|CDD|214861
NC_019751.1|WP_015197379.1|2011069_2011588_-|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl|CDD|379297
NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	gnl|CDD|375747
NC_019751.1|WP_041740355.1|2024394_2026578_+|type-I-D-CRISPR-associated-helicase-Cas3'	cas3	cd09710_cas3_CAS-I-D	gnl|CDD|187841
NC_019751.1|WP_015197380.1|2011944_2017071_-|acyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|274311
NC_019751.1|WP_015197386.1|2026795_2027065_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein	PD-DExK	COG4804_PD-DExK_CAS-I:CAS-III	gnl|CDD|377634
NC_019751.1|WP_015197383.1|2023763_2024024_+|DUF433-domain-containing-protein	unknown	unknown	gnl|CDD|377269
NC_019751.1|WP_015197373.1|1997880_1998786_-|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270406
NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	gnl|CDD|187842
NC_019751.1|WP_015197376.1|2002464_2004132_-|PfaD-family-polyunsaturated-fatty-acid/polyketide-biosynthesis-protein	unknown	unknown	gnl|CDD|240093
NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	cas10d	cd09712_cas10d_CAS-I-D	gnl|CDD|274469
NC_019751.1|WP_015197384.1|2024020_2024386_+|DUF5615-family-PIN-like-protein	unknown	unknown	gnl|CDD|375906
NC_019751.1|WP_015197372.1|1996772_1997747_+|quinolinate-synthase-NadA	unknown	unknown	gnl|CDD|236489
NC_019751.1|WP_015197387.1|2027326_2027773_+|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|376187
NC_019751.1|WP_041740351.1|1999606_2000350_+|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl|CDD|225002

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_019751.1|WP_041740355.1|2024394_2026578_+|type-I-D-CRISPR-associated-helicase-Cas3'	cas3	cd09710_cas3_CAS-I-D	3.9e-130	428.7	0.1
NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	cas10d	cd09712_cas10d_CAS-I-D	0	1063.7	2.1
NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein	PD-DExK	COG4804_PD-DExK_CAS-I:CAS-III	2.3e-45	149.0	6.6
NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	1.2e-103	340.9	0.1
NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	6.7e-85	278.6	2.6

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_041740352.1|2009215_2010940_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|274311	TIGR02813, omega-3_polyunsaturated_fatty_acid_synthase_PfaA, polyketide-type polyunsaturated fatty acid synthase PfaA. Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.	1.05464e-113
NC_019751.1|WP_015197388.1|2027769_2028213_+|DUF86-domain-containing-protein	gnl|CDD|366864	pfam01934, DUF86, Protein of unknown function DUF86. The function of members of this family is unknown.	7.18677e-19
NC_019751.1|WP_015197375.1|2000751_2002263_-|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|225857	COG3320, COG3320, Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	5.95174e-129
NC_019751.1|WP_041739263.1|2004385_2009074_-|PfaB-family-protein	gnl|CDD|238429	cd00833, PKS, polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.	3.50417e-127
NC_019751.1|WP_015197381.1|2017108_2018581_+|recombinase-family-protein	gnl|CDD|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	4.20067e-22
NC_019751.1|WP_015197379.1|2011069_2011588_-|carboxypeptidase-regulatory-like-domain-containing-protein	gnl|CDD|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	0.00225795
NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2	gnl|CDD|375747	pfam18320, Csc2, Csc2 Crispr. The Csc2 Crispr family of proteins forms a core RNA recognition motif-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	6.24537e-172
NC_019751.1|WP_041740355.1|2024394_2026578_+|type-I-D-CRISPR-associated-helicase-Cas3'	gnl|CDD|187841	cd09710, Cas3_I-D, CRISPR/Cas system-associated protein Cas3; Distinct diverged subfamily of Cas3 helicase domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Diverged DNA helicase Cas3'; signature gene for Type I and subtype I-D.	5.33412e-145
NC_019751.1|WP_015197380.1|2011944_2017071_-|acyltransferase-domain-containing-protein	gnl|CDD|274311	TIGR02813, omega-3_polyunsaturated_fatty_acid_synthase_PfaA, polyketide-type polyunsaturated fatty acid synthase PfaA. Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.	0
NC_019751.1|WP_015197387.1|2027326_2027773_+|nucleotidyltransferase-domain-containing-protein	gnl|CDD|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	1.72919e-17
NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein	gnl|CDD|377634	pfam06250, DUF1016, Protein of unknown function (DUF1016). Family of uncharacterized proteins found in viruses, archaea and bacteria.	8.32594e-84
NC_019751.1|WP_015197383.1|2023763_2024024_+|DUF433-domain-containing-protein	gnl|CDD|377269	pfam04255, DUF433, Protein of unknown function (DUF433).	3.16496e-24
NC_019751.1|WP_015197373.1|1997880_1998786_-|amino-acid-ABC-transporter-substrate-binding-protein	gnl|CDD|270406	cd13688, PBP2_GltI_DEBP, Substrate-binding domain of ABC aspartate-glutamate transporter; the type 2 periplasmic binding protein fold. This subfamily represents the periplasmic-binding protein component of ABC transporter specific for carboxylic amino acids, including GtlI from Escherichia coli. The aspartate-glutamate binding domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.39625e-79
NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1	gnl|CDD|187842	cd09711, Csc1_I-D, CRISPR/Cas system-associated protein Csc1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas5 ortholog; also known as CasA/Cse1 family.	5.80994e-87
NC_019751.1|WP_015197376.1|2002464_2004132_-|PfaD-family-polyunsaturated-fatty-acid/polyketide-biosynthesis-protein	gnl|CDD|240093	cd04742, NPD_FabD, 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDPs are members of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	0
NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	gnl|CDD|274469	TIGR03174, cas_Csc3, CRISPR type I-D/CYANO-associated protein Csc3/Cas10d. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. This family is designated Csc3 for CRISPR/Cas Subtype Cyano protein 3, as it is often the third gene upstream of the core cas genes, cas3-cas4-cas1-cas2.	0
NC_019751.1|WP_015197384.1|2024020_2024386_+|DUF5615-family-PIN-like-protein	gnl|CDD|375906	pfam18480, DUF5615, Domain of unknown function (DUF5615). This is a domain of unknown function found in potential toxin-antitoxin system component.	1.69926e-23
NC_019751.1|WP_015197372.1|1996772_1997747_+|quinolinate-synthase-NadA	gnl|CDD|236489	PRK09375, PRK09375, quinolinate synthase NadA.	0
NC_019751.1|WP_041740351.1|1999606_2000350_+|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl|CDD|225002	COG2091, Sfp, Phosphopantetheinyl transferase [Coenzyme metabolism].	1.81035e-49

Protein sequences

>NC_019751.1|WP_015197381.1|2017108_2018581_+|recombinase-family-protein
MRDLSRAIGYCRVSTQRQVTDGHGLERYIFRLKEFGLTDDNIYYDIESGDSETRAGYNRVLDLVRCRAVDTIIVPCFDRFTRSALGWEKARAELQEYNVELQFLDGGSLDLETPEGLFTSRILAAMAAQLRDKNKYNALQGAKYFREKKKIYQAIFGFVKVGETVEPNREEYRSTGKSHAAIAVEAIQIFISTGEIGGTIRKLVEKYGVERVSHLNYKDFPRDISAFKRWLLNPQLWGGICYYPTDSRRKIIVKSEHEGIISQSDHEEVLRLLKKPVGQRKKKRKNPLANIAICGVCGNRLEFHSYDRIVDDVKKSHQHLRCLGAYNKPGKPQVCDNRKYYRLEDAIAFACKHIQLASVEIAKRLDVESSPRRETIEILELKQQISQLKALNDPDLDPVIRSKEFKLSSAYGRLEIENQVQVGNVNYLEAIKGLFSLDKDWIFDIEIEELCVLFPELIESFVCSPPPEGKSPGGKYSKDSPGVFEVRLRT
>NC_019751.1|WP_015197380.1|2011944_2017071_-|acyltransferase-domain-containing-protein
MGKLARGKQLAMPLAARLEYPVWEKVLRTSGLSEEDTQKIIAKFKTAYVKWDENAFPGMLANVVAGRIANRLNFGGTNCVVDAACASSIAALKMAISELLEHRADIMLTGGVDTDNSIMAYISFSKTPAVTPGDNVKPFDAKSDGMMLGEGIGMIVLKRLADAERDGDKIYAVIKGIGTSSDGRYKSIYAPRQEGQVKALQRAYEDAGFSPATIGLVEAHGTGTMAGDPTEFASLREYFSVDNPRKQYIALGSVKSQIGHTKAAAGAASLIKTALALHHKVLPPTINVTEPNPKLNIKNSAFYINTETRPWIRAEGEAPRRAAVSSFGFGGTNYHVVLEEYTQETGKNSYRINNAPFEVLLSALNPGLLLTRCQEVLANLQSGNSEKQYVELVEESKTKNIPLNNARVGFIAESPQEAIKFLKMTVDLLHKQPNSPAWEHPQGIFYRESGLELGGKVVSLFSGQGSQYLEMGRELVMNFPALRNLYGYMDSLLLKDNMQPLSEIVFPHPVFEDAEKNAQIAALQRTEYAQPAIGMLSAGMYKILQQAGFKTDFVAGHSFGEITALWAAGVFNDEDYCKLVKARGQAMAPPQDPDYDAGAMLAVKEDLHKVEAVLRHFPRVMIANYNSQKQVVLAGPTAEINRVKQALQDQSYSAVSLPVSAAFHTPLIAFAQKSFAIALKSVQFQTPKLPVYSNTTGNQYANEPQTIQHILESHLSSSVLFKQEIEHIYAAGGSCFVEFGPRKILSNLVKEILGERPHLTIALNSNSQKNSDRTLREAVVQLRVAGMNLQNLDPFQQPLTVPPVTAGNKTLTIKLNGANFISEKTRKGWEETLNSTDKVQLMGTSDTVVTSTQEIQPVISAKELETVINSPVSSNGHHLPTVSNGKQPKFSIPQPDSTVSKVICSEVSQNEDFSGNSVVNPQYSELPQLTSSTNQPVRESKMQTIPNNPGDYQQILGSLEYVLTQFQQNQTENLQVHGLYLNNQKEYAQTFFQLMQQQNGLFAKNGNSDIKPVVMESLERSMMQFHSQQGETLRIHEQYLQNQIEYTQSFLKLIQQEYKQLIAGEVTVSSTILTESKSTPVFASVPTPTQVTPVVEGVPTPTQIQPVVESVAAPTQIKPVVESVPTPTQIQPVVETTPAPTQVTPVVESIPAPTQIQPVVESIPAPTQIQPVVESVPTPTQIQSVAANIPTVTIDLSDLGDKLLAITSEKTGYPVEMLEMDMDMEADLGIDSIKRVEILGGLQEIYPNLPEPNLEDLAELRTIGQIVEYLQTNNAPAKPVAPVEMMISAVQKATDIPIPELEITPTIPVITPDNTPTPVVSTTPTVSSTVSSDFANLDKSLLEITSEKTGYPVEMLELDMDMEADLGIDSIKRVEILGALQEAYPDLPKPDNMEELAELRTIGQIVTYLQNLAGGEKKKPESDSLEVESREQGEMRQGEQGSRGAGGDEELLQVSSLPITEFGEIHTPVNCNIKRLPARLLELGKPDFLDFTLPEGYVAIVTDDGTLTTTSVVQSLCDRGWKVVVLNFPASLVPEKSPLPQGVNRVALNDLSEEHLQQQLSAIADYFGTVAAFIHLHPHFPNNSPGILYHPDEKAIVKHVFFIAKYLKKPLVEAANHTRSCFLTVAHLDGSFGLKHQNNFGAIGAGLFGLSKTMLWEWANVYCRAVDLSPELTSNEAANSIIAEIHDANRYLIEVGYSKQGRVTLIAD
>NC_019751.1|WP_015197379.1|2011069_2011588_-|carboxypeptidase-regulatory-like-domain-containing-protein
MAKQTAISYIGRVIDYRKQAPISGAKVSFTAENNSLVTYTDLEGIYRFIVKPGDKKVLQGQIVVDAKGYPEYSSLIRLSTERKDLGDIRLGSRSKSSPSNYRSTSGSKEENSNLTVVIAIIVISFFTILAISLKSNPRREPINQQDDREFLNRYQRYQNKVPDRQRLNDFTF
>NC_019751.1|WP_041740352.1|2009215_2010940_-|SDR-family-NAD(P)-dependent-oxidoreductase
MPTPIFIKPTSIFVVSGGAKGITAACTIRLAQQYPCTFILLGRSELSDNEPEFARDCVDDATLKKRIMEQLIAQGEKPTPNSVQKIFNQITSNREIKATLAAIIKTGGKAEYLSVDITDSEKLKIKLAEISQRLGKITGIIHGAGNLADKLIEKKTSEDFEKVYTAKVQGLENLFNSIPSNQIEQLVLFSSVTGFYGNIGQSDYAIANEILNKSAHLVKTQHPNCHVVAINWGGWDSGMVTPQLKKEFARRGIEIIPVEAGTQMLVNELSPIHHNTAQVVIGSPMILPPAPLGTELRSHRVRRSLIGGDNPFLYDHKIAGNLILPATCAMSWIADTCERLYPGYRFFCATNFRVLKGISVSETDSTEYTVELQEISKIDGVEIQLQAKISSKLPNGKTTYHFASEPKLLVEIPQSPTYENLNLQTDNTITLQGSQFYQQNPSSLFHGKTFQQINRILNISPEKITAECHWASIGTKQQGQYPVDWMNPYATDLSTHPLWIWLYHYHQQICLPGQMEKYEQFERTPINTDYYVSCEIQQKTATGISANFIVHNQQGKIYSQLLGTKGVILPKLLE
>NC_019751.1|WP_041739263.1|2004385_2009074_-|PfaB-family-protein
MEKIAIIGYSCLLPDAKNPEEFWQNLIAQKDSTSPITTEELGIDPQTHYHPTKGKPDKYYSLKGTHIRDFKFDPKGYKLPPQLLNSLDNTSKWSLYAAKNALQHSGYLNNDPLLAHCGVILGTLSLPTRTSNQLLAPIYQQILNPAIRQLLETENFQLPAPSETSHHNAMISGMPAAIIAQALSLSSTHFCIDAACSSPQYAIRLASHYLWTHKADMMLAGGVSAADPLFLRMLFSGLQAYPEDNDISRPLDKTSRGLMTGEGTGMFVLKRYSDAVRDGDRIYATITGNGLSNDGKGKHLLSPNSKGQVLAFERAYAEAGINPKDIDYLECHATGTLLGDTTEFNSVETFFGQHQASPLVGSAKANVGHLLVGAGSVGLLKVILSMGKGVIPATINIGEPIGNETNVISPKKIVRSTTNWQKNGNIKRAAISAFGFGGTNAHMIVEEGGNQASHAEAPLEVAKIAVVGMDAYFGNCKNLDEFERSIYDGIQHFIPLPEKRWRGVEKETDLLKQYGLSEGKAPMGAYIQDFEFDMISSKIPPNELDKLNPQQLLLLKVAERALKDAEIQPGGKVAVIIAAETELSVHQLQQRWNLSWQVKDGLDVELAETSQLETILKDSIHNPVELGEFVSYISNIMASRISALWDFNAPTFTMTAGENSTFKALEVAQHLLTTGEAESVLVGAVDLAGGLENVLLRSQQTPMNTGTQTLSFDAKVHGLTVGEGAGAVVLQKYDPKATKKVYAVVDAIAFAQKHALGVADAGTIKQVSNHAFAVAGIKPDAVNYLEVSASGISQADTAEIQGLVQAYPGSENRLSCAVGSVKSNIGHTFTASGIASFIKTALCLYHRYIPGTPQWSGVKEQEQWHGSPFYVAPTSRPWLLSKHTTRRVAAINGIGADGSYAHLIVSEAEQQGERQSRYLQQMPLYLFPLAGDSKEELLTQLDALKSTVQNSTHLQNSASLSFTQFQQKATAKYTLVILGRNHKELLREMESAAKGVTNAFEKGEPWQTPIGSYFTPKPLGKTGEIAYVYPAAINAYVGIAQNIGRLYPQVHDDAMITSLYTAVDDIEKFLYPRSLNKLSTRQLENLEKELLDNSLAMFETEICIARLLTTIIRDRFQAKPKFAFGYSLGETSMMFAQGVWSDFNEGIKKFHASPLFGDRVSGQKNALREYWKLPSFAESPADDFWSTHVLIAKPEQVREAIKNETRVYLTQISTPEEVVIAGEPGGCQRVIKALGCNAFAAPFNHLIHCEAMQSEYNEIVRVNNLPAQPVGDIAFYSSAEYTPVALEGNAIAQSIGKCLTTPLDFPRLVNQIYSQGARIFIEAGAGNVCSRWIDKILENQEHVTVSLNRRGTDDHSSIVRALAKLTSHRVNLDLSSLYNCETATTKKTSYKTITLGGASITGAILTEDNKKLFQDVLKKQHSQAVIPQLPAKSLIPVSEVVNLPEITSQKTNEGDIFSTTKKPEQKLEKVTMKHDINNSYAAKEQLQFCELDVKQHQTPQLIPQSQQSHYPSTTLHFQKLSQNNSRVHKTHATFLQSRQDFSHSISEIIQLQIACAENLLNE
>NC_019751.1|WP_015197376.1|2002464_2004132_-|PfaD-family-polyunsaturated-fatty-acid/polyketide-biosynthesis-protein
MKTVDTVTNPRDNGLKFNTFSFYQNQVWKGSTDCISFDQNSIKEKLLNLNQPCYVVRVDGRIGIANGGYAAPQDDAKTGEVELITAVPPIKIQNLGDPNFLSFYGTKYAYMTGAMAGGIASAEMIIALGKAKLMGSFGAGGLTPSRLEAAINQIQSALINEPYCFNLIHSPNDLAIERRAVDLYLKYGVRVVEASAFLDLTPNIVYYRAAGLGLNSANEIEIRNKVIAKVSRREVATKFLQPAPIKILQDLVNQGLISELQANLAARLPVADDITVEADSGGHTDNRPLVCLLPSMLALRDEIQAKYQYEKPIRIGVAGGISNPQSALAGLMMGAAYIVTGSVNQSCVESGSCEHTKKLLAQAEMADMMMAPAADMFEMGVKLQVLKRGTMFPMRAQKLYELYRTYDSIDDIPMAEREKLEKQIFRQSLSEVWEGTVSYLSQTNPEKLAKAVNNPKLKMAAIFKWYLGLSSRWSSSGEKGREVDYQIWCGPAMGSFNEWVKGTYLEEANNRLVVDVANQIMSGAAYLYRVQSLRVQGLQIGDCYGQFYPQVSSLE
>NC_019751.1|WP_015197375.1|2000751_2002263_-|NAD-dependent-epimerase/dehydratase-family-protein
MVSPKKSMTAEEIQVWMAGKLAELLKVEVDEVDVNLPLEDYGLDSARAMVLVGQVEKKLGVELSPVLLWHYPTIAALSVRLAEDSEDVSDAKSTGVSVVKPLDISVDLGAEVVLDPSIYPAKNSFRFNGEPENVFVTGATGFLGGFIIYELLKQTSCDVYCLVRAANTEAGKIKLKKNLEQYAIWDDEFEPRIIPILGDLSQPLLGISQEGFEMLAANMDAIYHSAATLNYVYPYSALKTANVLGTQEVLRMACMIRVKPVHYVSSVAVFESSAYAGKIVKEDDAFEHWQGIFLGYSQTKWVAEKLVKAASDRGLPVTIHRPPLIGGDSQTGVCNGDDFINLMIKGCIQMGAFPDVDYKMDFSPVDYVSKAIVHLSRQKESLGKAFHLQHPQPVPLKELVEWISSFGFSVKSIPYKEWQQKLTEITDNSNPLYTLRPFLLERWSKEQLTIPDLYLQTQRPIISCQATLHALSGSGVSCPPIDSRLFMTYSAYLIQSGFLSFGS
>NC_019751.1|WP_041740351.1|1999606_2000350_+|4'-phosphopantetheinyl-transferase-superfamily-protein
MQNSKLRSLTIDSDRQWLVAPNDVKLLPDDIHVWRIELERSESQIKQFAKILSEDERGRAEKLYFQQHRQRFVVGRGILRTILGRYLDVAPQEVKFDYEAFGKPVLSAEFSDRKIWFNLSHCQSLALCAVSRDRPIGVDLEYARPITDVLVLAQQFFSASESALMRSLPPHQKQQAFFRIWTCKEAYLKATGAGISQLQKIEITLTPGESAKLNVPDWRLLEISAGRNSIAAVAVPGTAANLRYWQY
>NC_019751.1|WP_015197373.1|1997880_1998786_-|amino-acid-ABC-transporter-substrate-binding-protein
MYTKTALICLGVMFSSVISLPANAETVMAKINRTGVLTAGTSKDAIPFAYADSKGKLTGYSVDMLVLMKEQLEKQLGKKIQLKLVSLSPAERIPKILKNEVDIVCDASSFTWERDKQVDFSVSYAVTGTQLLVKKNSNLDSAESFVAKQVGVLSKTTNEQAMKRFQPQAKLVYFPTRNQAYSALQQGKIDAFASDGILSEGWLRTQKNPDAFKIVPSLPLSREGVACMVPENNSKFLDTVNYSLIKFMQGFVSGNPRNVTIFDRSFGAKGAVFINKDIRDLTIETMQLVIESRQEIGERDF
>NC_019751.1|WP_015197372.1|1996772_1997747_+|quinolinate-synthase-NadA
MFTTALPQREKEQLGTFPLDLFTAITELKKELNAVILAHYYQEPDIQDIADYIGDSLQLARAAAETNADVIVFAGVHFMAETAKILNPDKLVLLPDLDAGCSLADTCPPQEFAAFKAAHPGHLVISYINCTAEIKAMSDIICTSSNAVKIVQQIPKEQPIIFAPDRNLGRYVMEQTGRDMVLWQGSCIVHETFSEKKIVQLKIANPEAEIIAHPECEASVLRHADYIGSTAALLKYCQDSKSSKFIVATEPGIIHQMQKVASEKQFIPAPPENNCNCNECPFMRLNTMDKLYLAMKNRTPEITMSEEIRSAALLPMQRMLEMSK
>NC_019751.1|WP_015197383.1|2023763_2024024_+|DUF433-domain-containing-protein
MTSENLLARISIDPNICFGKPCIKGHRIWVSMILDYLAGGETIEGILEAYPSIEREDILACIAYGAEMSRGAFVEIPLTKKKEATA
>NC_019751.1|WP_015197384.1|2024020_2024386_+|DUF5615-family-PIN-like-protein
MNLKLDENIDARVITLLRLAGHDVATVPEKGLMSAPDEEVIEVCRREERCLVTCDRGFGNRVKYNPSNYAGIVIIRLPSRYTFADCQQAIEILIQGLESAEVTGKLWIIQRGNIQEYQAIE
>NC_019751.1|WP_041740355.1|2024394_2026578_+|type-I-D-CRISPR-associated-helicase-Cas3'
MNESIYQVNLKSVYSSPVESELQDVTLPKNWRLSWHQAETLKALRNPNIDVIINTAMTGDGKSLAAYLEVLQGEFSAIGLYPTNELARDQEIQIKGYIDTFKPANNPRVARLSSAELEIYAENEGLKKSAAISTLTNQREVILTNPDILHYLHRGAYLIPGDSPDKLWGRIDKDFNLFIFDEFHIFAAPQIAGVINTMLLMNCTNRHKKFLFLSATPDKDFIDKLKLAGFRCQEINPLDNQKYQFPDNLEQEQELQLQNWRQVSRSINLNFISLEPSFKASETWIKENSNLILEYFQNNPGSKGAIILNSIAAVKRLVSFFQEIFQTHGLIVGENTGLSGKITKEKSLLADLVFGTSTIDVGVDFKINLLIFESSDAGNFIQRLGRLGRHDGYNKDGEDIKFEKYTAYALVPNFLVERLFLGDNPPLKNTENYNRAFLNATIKDKYRQINDFRGYYKRWGAVQSFYLFHKLSDRTIQQPYAQSREKFQKACESVFNTSLKSIAGRVSGWAKDWKNASGKSGNPIAEDASSFRGASSLQCGLYDLTEENPADRFKTYDLPGILGNLEIEMWTETGFMRTLKETAQVTGQPIPKGKYEYCLGFMKLRSYREERLNWKFVYPGDLQPVADAWKVQVLTGIEVWQPDNNYVREINKRLKKQALVCYVLRRPIAEVRNRLRLPMHFQLYPICDELSLHDSSAPYAIAFGQSALLLDTLAYTFKSKGDESWII
>NC_019751.1|WP_015197386.1|2026795_2027065_+|hypothetical-protein
MLSHNADPHLLNLLMNADLEQINQALILRLVTENCGFKHRIDTLESQNEEILQKLDNLENIYNEIPYLRHLVDQNEELQNLVDFYCPPD
>NC_019751.1|WP_015197387.1|2027326_2027773_+|nucleotidyltransferase-domain-containing-protein
MNTPTIEKLKQLAQQIPEKIPYLKMLVLFGSRATGETHVNSDWDFAVLIDKAQQEIYTKDNAWGAFGLSMFIGEILNINPDKIDIVELNHCSWLIAHFVARDGILIFEKESSGFEYFRLTSLRPESELKKFRKEQHQLIEMQLKQWSI
>NC_019751.1|WP_015197388.1|2027769_2028213_+|DUF86-domain-containing-protein
MSKIDPEIVLARLRLITKYKNTLEEFRSININEFLAEFRQQLIVERLLQLMIQAAIDINDHILSRLNPGNSATNFEAFIELGKYEVITSELAKQLAPSGSLRNRLVHEYDDIDPNQVYQAIKFALQQYPLYVQQINAYLISLDTESS
>NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein
MNKPTSEEYINLLVEVKQRIRSAQYEALKAVNKELIALYWDIGKMIVTRQEGATWGKSVVEQLAKDLQNEFPGISGFSTANLWRMRLFYDTFANNEKLAPMVREIGWTHNLVILEKCKDDLEREFYIRMTRKFGWTKNVLIHQIENQTYEKTLLNQTNFNQTVSEEIRNQAKLAVKDEYTFDFLELADEHSERQLEQAILTRVEPFLKEMGGMFAFIGSQYRLEIDDEEYFIDILLYHRILKCLIAVELKIGKFLPEYIGKMQFYLAALDDKVRQPDENPSIGIILCKSKNKTIVEYALRESNKPIGVATYQIVSTVPQELINQLPEPEQVAKLLQGIE
>NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3
MAKKTKKSEESKQLSLFESGLDLNSEITDEADDNWLEGDFGFDGDSDRTIETKSELLTLKLLREAIKAQNPDDQVMADFGEYVLPNLLSIAIGVTAKGGKFFDEIDEKREAEGKAKVRRDNAADQSLNTHLLNGLFPANLIERRLHKLDTTVQRVVRERERRLVIAGFILHDFEKFPDVPNDCRKLPLEEHRQIIDEKVRQLGLDKFIDSENTEAYKEYIDDLLCMAYNAQRRWDTNWNFSEFGLNPLLKDRTLRSLSDLTCLADSLASIIKHPQDAENPRLNEIIHSLSDGKLKFTYHRISENRGVLTNVVNNALIQVHTKLNTDENIYYEPLLYLPTGVIYLARRDAPEISLDDVPNQVIENIKSLCSGQLKLRQTGFGRDGKGMKYAEYYNLFFDEIGLMKVALDATLRILNPNKDSVAKSRSDNLVKFQQQKVLSVDYDFKFTDDIRIDQIAEFGDLICRKIWDESANRIEVACKKDKNLPKLTQLDLTYKVAEFWELAEYLPQIREIQRINESLKENKLKGNTGGVPYEWYYLAAKFLEKHPGIENVRESCQQVIEYINNLISPIISQYELPDGWNDLRLWVKQVVMLPGNQETQTPDNFLNELANYNAAKKSGRGRQLICSISHSAYTVTEQMESAVLFTPQVYTNKQMLNGSNAKRNISSIAGLEMMLRQILMNQTQAVGKRFEDGKYRYLYFYPTYYFTPETNKFLQKAYTGISQTRFDTRIRNHFISKDLQANFDKDTYQNVDAFLIDENLDSDKDRTFKLSYPDDQPLTFYFMAMPPGRDSSDTESWVMPTWLAFAFPMILDVKTVVSESPIPPFNDGAEFEESVFLDSAPHAFRTLVGRDRFRLDYILEGWTENNKSYPAPLNVLTAAYAIHIDVNAKSGKSGYDANWGRFTELAKDFETTPLYVFAYLNRWVRSQGVETARIEKIRLYAHKFYPCFDPYAQYDFESKEWKLMPESQLNHPKKLTDLYRKFYRANKRYNPKSNAVLKPIDIAAETILKAEVSVFSGETLVAAVAAEVFKLMDRVHANTADGRWVMSKREEERQAVLDFARYFVMDVFENSFSSDRARLAGRQLNLIKDTCEFLYRLEDDKENANKDVKEEENDKNED
>NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2
MSFLKTVDAKFFHSEIPYKPMGKYVHFLTVRVTESYPLFQTDSELNKARVRAGIVDKTTISRLSMFKRKQSTPERLVGRELLRNYGLMTAEECEYNVKFAMNNPDCIIYGFAIGDSGSEKSKVVVDTAFSIKSFDESHETFTLNAPFENGTMASKGENGSKVGEVTSRINQQDHIKPQVFFPSIVTLKDPTEASFLYVFNNILRTRHYGAQTTRTGRVRNELIGVIFADGEIVSNLRWTQAIYDQMKSNNTLNSPDPLNEDEVFVSAKVSISTLMEDEFIVHEDFLGDKFAALLKEVKAITANEEELKKMLKKADDEAKAYAKVHIKGKDKEKDKDKAAAK
>NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1
MTIIYRCQIELHDSVYYATREIGRLYETEPIIHNYALCYALGLVDSEKYATTVSEEHSYRYFCPEQVPKYEEHLTPLNKQGIYVTPACSISHTSILNTWKYANNNYHVEMEKTQKNIPSFGRAKEIAPESVFEFLIISQNELKLPKWIRLGKWMSKAEVTVEKLPEPKTKTDLFICTHPLNPLDVMFTNQVISYDVINMPPVSLIQNVQMRGQYYYFENVKDVRLPVNISYRFRN

Crispr_ID: NC_019751_8

• CRISPR_ID: NC_019751_8
• CRISPR_location: 2026580-2026681
• CRISPR_type: TypeI-D
• Repeat_type: I-D,II-B
• Spacer_info: 1 spacers
• Cas_protein_info: cas3,PD-DExK,cas10d,csc2gr7,csc1gr5,cas6,cas4,cas1

Consensus repeat of NC_019751_8

Consensus_repeat	Method
GTTTCAATCCCTAATAGGGATTA	CRISPRCasFinder

spacers of NC_019751_8

>8.1|2026603|56|NC_019751|CRISPRCasFinder
GAGACTTGTGTTTTATGCAAGCAAGGGAGAAGCCAATCATTATAAGGATAGCTCGT

CRISPR arrays and Neighbor proteins around NC_019751_8

CRISPR arrays

The CRISPR arrays of NC_019751_8

>merge|NC_019751|8|2026580-2026681|CRISPRCasFinder
GTTTCAATCCCTAATAGGGATTAGAGACTTGTGTTTTATGCAAGCAAGGGAGAAGCCAATCATTATAAGGATAGCTCGTGTTTCAATCCCTGATAGGGATTA

>NC_019751|8|8|2026580-2026681|CRISPRCasFinder
GTTTCAATCCCTAATAGGGATTA	GAGACTTGTGTTTTATGCAAGCAAGGGAGAAGCCAATCATTATAAGGATAGCTCGT
GTTTCAATCCCTGATAGGGATTA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_041740352.1|2009215_2010940_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274311
NC_019751.1|WP_015197388.1|2027769_2028213_+|DUF86-domain-containing-protein	unknown	unknown	gnl|CDD|366864
NC_019751.1|WP_015197375.1|2000751_2002263_-|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|225857
NC_019751.1|WP_041739263.1|2004385_2009074_-|PfaB-family-protein	unknown	unknown	gnl|CDD|238429
NC_019751.1|WP_015197381.1|2017108_2018581_+|recombinase-family-protein	unknown	unknown	gnl|CDD|214861
NC_019751.1|WP_015197395.1|2036526_2037531_+|type-I-D-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl|CDD|274976
NC_019751.1|WP_015197379.1|2011069_2011588_-|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl|CDD|379297
NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	gnl|CDD|375747
NC_019751.1|WP_041740355.1|2024394_2026578_+|type-I-D-CRISPR-associated-helicase-Cas3'	cas3	cd09710_cas3_CAS-I-D	gnl|CDD|187841
NC_019751.1|WP_015197380.1|2011944_2017071_-|acyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|274311
NC_019751.1|WP_015197386.1|2026795_2027065_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein	PD-DExK	COG4804_PD-DExK_CAS-I:CAS-III	gnl|CDD|377634
NC_019751.1|WP_015197383.1|2023763_2024024_+|DUF433-domain-containing-protein	unknown	unknown	gnl|CDD|377269
NC_019751.1|WP_015197394.1|2035825_2036416_+|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl|CDD|187768
NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	gnl|CDD|187842
NC_019751.1|WP_015197376.1|2002464_2004132_-|PfaD-family-polyunsaturated-fatty-acid/polyketide-biosynthesis-protein	unknown	unknown	gnl|CDD|240093
NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	cas10d	cd09712_cas10d_CAS-I-D	gnl|CDD|274469
NC_019751.1|WP_015197393.1|2034943_2035783_+|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl|CDD|227838
NC_019751.1|WP_015197387.1|2027326_2027773_+|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|376187
NC_019751.1|WP_015197384.1|2024020_2024386_+|DUF5615-family-PIN-like-protein	unknown	unknown	gnl|CDD|375906

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_019751.1|WP_041740355.1|2024394_2026578_+|type-I-D-CRISPR-associated-helicase-Cas3'	cas3	cd09710_cas3_CAS-I-D	3.9e-130	428.7	0.1
NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein	PD-DExK	COG4804_PD-DExK_CAS-I:CAS-III	2.3e-45	149.0	6.6
NC_019751.1|WP_015197394.1|2035825_2036416_+|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	8.2e-48	157.6	0.7
NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	6.7e-85	278.6	2.6
NC_019751.1|WP_015197395.1|2036526_2037531_+|type-I-D-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	4.5e-100	329.7	0.0
NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	cas10d	cd09712_cas10d_CAS-I-D	0	1063.7	2.1
NC_019751.1|WP_015197393.1|2034943_2035783_+|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	4.3e-58	191.6	0.0
NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	1.2e-103	340.9	0.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_041740352.1|2009215_2010940_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|274311	TIGR02813, omega-3_polyunsaturated_fatty_acid_synthase_PfaA, polyketide-type polyunsaturated fatty acid synthase PfaA. Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.	1.05464e-113
NC_019751.1|WP_015197388.1|2027769_2028213_+|DUF86-domain-containing-protein	gnl|CDD|366864	pfam01934, DUF86, Protein of unknown function DUF86. The function of members of this family is unknown.	7.18677e-19
NC_019751.1|WP_015197375.1|2000751_2002263_-|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|225857	COG3320, COG3320, Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	5.95174e-129
NC_019751.1|WP_041739263.1|2004385_2009074_-|PfaB-family-protein	gnl|CDD|238429	cd00833, PKS, polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.	3.50417e-127
NC_019751.1|WP_015197381.1|2017108_2018581_+|recombinase-family-protein	gnl|CDD|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	4.20067e-22
NC_019751.1|WP_015197395.1|2036526_2037531_+|type-I-D-CRISPR-associated-endonuclease-Cas1	gnl|CDD|274976	TIGR04093, hypothetical_protein_L8106_25395, CRISPR-associated endonuclease Cas1, subtype CYANO. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes a clade of Cas1 limited to the CYANO subtype of CRISPR/Cas system and most often the type found there.	1.77967e-142
NC_019751.1|WP_015197379.1|2011069_2011588_-|carboxypeptidase-regulatory-like-domain-containing-protein	gnl|CDD|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	0.00225795
NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2	gnl|CDD|375747	pfam18320, Csc2, Csc2 Crispr. The Csc2 Crispr family of proteins forms a core RNA recognition motif-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	6.24537e-172
NC_019751.1|WP_041740355.1|2024394_2026578_+|type-I-D-CRISPR-associated-helicase-Cas3'	gnl|CDD|187841	cd09710, Cas3_I-D, CRISPR/Cas system-associated protein Cas3; Distinct diverged subfamily of Cas3 helicase domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Diverged DNA helicase Cas3'; signature gene for Type I and subtype I-D.	5.33412e-145
NC_019751.1|WP_015197380.1|2011944_2017071_-|acyltransferase-domain-containing-protein	gnl|CDD|274311	TIGR02813, omega-3_polyunsaturated_fatty_acid_synthase_PfaA, polyketide-type polyunsaturated fatty acid synthase PfaA. Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.	0
NC_019751.1|WP_015197387.1|2027326_2027773_+|nucleotidyltransferase-domain-containing-protein	gnl|CDD|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	1.72919e-17
NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein	gnl|CDD|377634	pfam06250, DUF1016, Protein of unknown function (DUF1016). Family of uncharacterized proteins found in viruses, archaea and bacteria.	8.32594e-84
NC_019751.1|WP_015197383.1|2023763_2024024_+|DUF433-domain-containing-protein	gnl|CDD|377269	pfam04255, DUF433, Protein of unknown function (DUF433).	3.16496e-24
NC_019751.1|WP_015197394.1|2035825_2036416_+|CRISPR-associated-protein-Cas4	gnl|CDD|187768	cd09637, Cas4_I-A_I-B_I-C_I-D_II-B, CRISPR/Cas system-associated protein Cas4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster.	1.70228e-50
NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1	gnl|CDD|187842	cd09711, Csc1_I-D, CRISPR/Cas system-associated protein Csc1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas5 ortholog; also known as CasA/Cse1 family.	5.80994e-87
NC_019751.1|WP_015197376.1|2002464_2004132_-|PfaD-family-polyunsaturated-fatty-acid/polyketide-biosynthesis-protein	gnl|CDD|240093	cd04742, NPD_FabD, 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDPs are members of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	0
NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	gnl|CDD|274469	TIGR03174, cas_Csc3, CRISPR type I-D/CYANO-associated protein Csc3/Cas10d. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. This family is designated Csc3 for CRISPR/Cas Subtype Cyano protein 3, as it is often the third gene upstream of the core cas genes, cas3-cas4-cas1-cas2.	0
NC_019751.1|WP_015197393.1|2034943_2035783_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.28894e-44
NC_019751.1|WP_015197384.1|2024020_2024386_+|DUF5615-family-PIN-like-protein	gnl|CDD|375906	pfam18480, DUF5615, Domain of unknown function (DUF5615). This is a domain of unknown function found in potential toxin-antitoxin system component.	1.69926e-23

Protein sequences

>NC_019751.1|WP_041740355.1|2024394_2026578_+|type-I-D-CRISPR-associated-helicase-Cas3'
MNESIYQVNLKSVYSSPVESELQDVTLPKNWRLSWHQAETLKALRNPNIDVIINTAMTGDGKSLAAYLEVLQGEFSAIGLYPTNELARDQEIQIKGYIDTFKPANNPRVARLSSAELEIYAENEGLKKSAAISTLTNQREVILTNPDILHYLHRGAYLIPGDSPDKLWGRIDKDFNLFIFDEFHIFAAPQIAGVINTMLLMNCTNRHKKFLFLSATPDKDFIDKLKLAGFRCQEINPLDNQKYQFPDNLEQEQELQLQNWRQVSRSINLNFISLEPSFKASETWIKENSNLILEYFQNNPGSKGAIILNSIAAVKRLVSFFQEIFQTHGLIVGENTGLSGKITKEKSLLADLVFGTSTIDVGVDFKINLLIFESSDAGNFIQRLGRLGRHDGYNKDGEDIKFEKYTAYALVPNFLVERLFLGDNPPLKNTENYNRAFLNATIKDKYRQINDFRGYYKRWGAVQSFYLFHKLSDRTIQQPYAQSREKFQKACESVFNTSLKSIAGRVSGWAKDWKNASGKSGNPIAEDASSFRGASSLQCGLYDLTEENPADRFKTYDLPGILGNLEIEMWTETGFMRTLKETAQVTGQPIPKGKYEYCLGFMKLRSYREERLNWKFVYPGDLQPVADAWKVQVLTGIEVWQPDNNYVREINKRLKKQALVCYVLRRPIAEVRNRLRLPMHFQLYPICDELSLHDSSAPYAIAFGQSALLLDTLAYTFKSKGDESWII
>NC_019751.1|WP_015197384.1|2024020_2024386_+|DUF5615-family-PIN-like-protein
MNLKLDENIDARVITLLRLAGHDVATVPEKGLMSAPDEEVIEVCRREERCLVTCDRGFGNRVKYNPSNYAGIVIIRLPSRYTFADCQQAIEILIQGLESAEVTGKLWIIQRGNIQEYQAIE
>NC_019751.1|WP_015197383.1|2023763_2024024_+|DUF433-domain-containing-protein
MTSENLLARISIDPNICFGKPCIKGHRIWVSMILDYLAGGETIEGILEAYPSIEREDILACIAYGAEMSRGAFVEIPLTKKKEATA
>NC_019751.1|WP_015197381.1|2017108_2018581_+|recombinase-family-protein
MRDLSRAIGYCRVSTQRQVTDGHGLERYIFRLKEFGLTDDNIYYDIESGDSETRAGYNRVLDLVRCRAVDTIIVPCFDRFTRSALGWEKARAELQEYNVELQFLDGGSLDLETPEGLFTSRILAAMAAQLRDKNKYNALQGAKYFREKKKIYQAIFGFVKVGETVEPNREEYRSTGKSHAAIAVEAIQIFISTGEIGGTIRKLVEKYGVERVSHLNYKDFPRDISAFKRWLLNPQLWGGICYYPTDSRRKIIVKSEHEGIISQSDHEEVLRLLKKPVGQRKKKRKNPLANIAICGVCGNRLEFHSYDRIVDDVKKSHQHLRCLGAYNKPGKPQVCDNRKYYRLEDAIAFACKHIQLASVEIAKRLDVESSPRRETIEILELKQQISQLKALNDPDLDPVIRSKEFKLSSAYGRLEIENQVQVGNVNYLEAIKGLFSLDKDWIFDIEIEELCVLFPELIESFVCSPPPEGKSPGGKYSKDSPGVFEVRLRT
>NC_019751.1|WP_015197380.1|2011944_2017071_-|acyltransferase-domain-containing-protein
MGKLARGKQLAMPLAARLEYPVWEKVLRTSGLSEEDTQKIIAKFKTAYVKWDENAFPGMLANVVAGRIANRLNFGGTNCVVDAACASSIAALKMAISELLEHRADIMLTGGVDTDNSIMAYISFSKTPAVTPGDNVKPFDAKSDGMMLGEGIGMIVLKRLADAERDGDKIYAVIKGIGTSSDGRYKSIYAPRQEGQVKALQRAYEDAGFSPATIGLVEAHGTGTMAGDPTEFASLREYFSVDNPRKQYIALGSVKSQIGHTKAAAGAASLIKTALALHHKVLPPTINVTEPNPKLNIKNSAFYINTETRPWIRAEGEAPRRAAVSSFGFGGTNYHVVLEEYTQETGKNSYRINNAPFEVLLSALNPGLLLTRCQEVLANLQSGNSEKQYVELVEESKTKNIPLNNARVGFIAESPQEAIKFLKMTVDLLHKQPNSPAWEHPQGIFYRESGLELGGKVVSLFSGQGSQYLEMGRELVMNFPALRNLYGYMDSLLLKDNMQPLSEIVFPHPVFEDAEKNAQIAALQRTEYAQPAIGMLSAGMYKILQQAGFKTDFVAGHSFGEITALWAAGVFNDEDYCKLVKARGQAMAPPQDPDYDAGAMLAVKEDLHKVEAVLRHFPRVMIANYNSQKQVVLAGPTAEINRVKQALQDQSYSAVSLPVSAAFHTPLIAFAQKSFAIALKSVQFQTPKLPVYSNTTGNQYANEPQTIQHILESHLSSSVLFKQEIEHIYAAGGSCFVEFGPRKILSNLVKEILGERPHLTIALNSNSQKNSDRTLREAVVQLRVAGMNLQNLDPFQQPLTVPPVTAGNKTLTIKLNGANFISEKTRKGWEETLNSTDKVQLMGTSDTVVTSTQEIQPVISAKELETVINSPVSSNGHHLPTVSNGKQPKFSIPQPDSTVSKVICSEVSQNEDFSGNSVVNPQYSELPQLTSSTNQPVRESKMQTIPNNPGDYQQILGSLEYVLTQFQQNQTENLQVHGLYLNNQKEYAQTFFQLMQQQNGLFAKNGNSDIKPVVMESLERSMMQFHSQQGETLRIHEQYLQNQIEYTQSFLKLIQQEYKQLIAGEVTVSSTILTESKSTPVFASVPTPTQVTPVVEGVPTPTQIQPVVESVAAPTQIKPVVESVPTPTQIQPVVETTPAPTQVTPVVESIPAPTQIQPVVESIPAPTQIQPVVESVPTPTQIQSVAANIPTVTIDLSDLGDKLLAITSEKTGYPVEMLEMDMDMEADLGIDSIKRVEILGGLQEIYPNLPEPNLEDLAELRTIGQIVEYLQTNNAPAKPVAPVEMMISAVQKATDIPIPELEITPTIPVITPDNTPTPVVSTTPTVSSTVSSDFANLDKSLLEITSEKTGYPVEMLELDMDMEADLGIDSIKRVEILGALQEAYPDLPKPDNMEELAELRTIGQIVTYLQNLAGGEKKKPESDSLEVESREQGEMRQGEQGSRGAGGDEELLQVSSLPITEFGEIHTPVNCNIKRLPARLLELGKPDFLDFTLPEGYVAIVTDDGTLTTTSVVQSLCDRGWKVVVLNFPASLVPEKSPLPQGVNRVALNDLSEEHLQQQLSAIADYFGTVAAFIHLHPHFPNNSPGILYHPDEKAIVKHVFFIAKYLKKPLVEAANHTRSCFLTVAHLDGSFGLKHQNNFGAIGAGLFGLSKTMLWEWANVYCRAVDLSPELTSNEAANSIIAEIHDANRYLIEVGYSKQGRVTLIAD
>NC_019751.1|WP_015197379.1|2011069_2011588_-|carboxypeptidase-regulatory-like-domain-containing-protein
MAKQTAISYIGRVIDYRKQAPISGAKVSFTAENNSLVTYTDLEGIYRFIVKPGDKKVLQGQIVVDAKGYPEYSSLIRLSTERKDLGDIRLGSRSKSSPSNYRSTSGSKEENSNLTVVIAIIVISFFTILAISLKSNPRREPINQQDDREFLNRYQRYQNKVPDRQRLNDFTF
>NC_019751.1|WP_041740352.1|2009215_2010940_-|SDR-family-NAD(P)-dependent-oxidoreductase
MPTPIFIKPTSIFVVSGGAKGITAACTIRLAQQYPCTFILLGRSELSDNEPEFARDCVDDATLKKRIMEQLIAQGEKPTPNSVQKIFNQITSNREIKATLAAIIKTGGKAEYLSVDITDSEKLKIKLAEISQRLGKITGIIHGAGNLADKLIEKKTSEDFEKVYTAKVQGLENLFNSIPSNQIEQLVLFSSVTGFYGNIGQSDYAIANEILNKSAHLVKTQHPNCHVVAINWGGWDSGMVTPQLKKEFARRGIEIIPVEAGTQMLVNELSPIHHNTAQVVIGSPMILPPAPLGTELRSHRVRRSLIGGDNPFLYDHKIAGNLILPATCAMSWIADTCERLYPGYRFFCATNFRVLKGISVSETDSTEYTVELQEISKIDGVEIQLQAKISSKLPNGKTTYHFASEPKLLVEIPQSPTYENLNLQTDNTITLQGSQFYQQNPSSLFHGKTFQQINRILNISPEKITAECHWASIGTKQQGQYPVDWMNPYATDLSTHPLWIWLYHYHQQICLPGQMEKYEQFERTPINTDYYVSCEIQQKTATGISANFIVHNQQGKIYSQLLGTKGVILPKLLE
>NC_019751.1|WP_041739263.1|2004385_2009074_-|PfaB-family-protein
MEKIAIIGYSCLLPDAKNPEEFWQNLIAQKDSTSPITTEELGIDPQTHYHPTKGKPDKYYSLKGTHIRDFKFDPKGYKLPPQLLNSLDNTSKWSLYAAKNALQHSGYLNNDPLLAHCGVILGTLSLPTRTSNQLLAPIYQQILNPAIRQLLETENFQLPAPSETSHHNAMISGMPAAIIAQALSLSSTHFCIDAACSSPQYAIRLASHYLWTHKADMMLAGGVSAADPLFLRMLFSGLQAYPEDNDISRPLDKTSRGLMTGEGTGMFVLKRYSDAVRDGDRIYATITGNGLSNDGKGKHLLSPNSKGQVLAFERAYAEAGINPKDIDYLECHATGTLLGDTTEFNSVETFFGQHQASPLVGSAKANVGHLLVGAGSVGLLKVILSMGKGVIPATINIGEPIGNETNVISPKKIVRSTTNWQKNGNIKRAAISAFGFGGTNAHMIVEEGGNQASHAEAPLEVAKIAVVGMDAYFGNCKNLDEFERSIYDGIQHFIPLPEKRWRGVEKETDLLKQYGLSEGKAPMGAYIQDFEFDMISSKIPPNELDKLNPQQLLLLKVAERALKDAEIQPGGKVAVIIAAETELSVHQLQQRWNLSWQVKDGLDVELAETSQLETILKDSIHNPVELGEFVSYISNIMASRISALWDFNAPTFTMTAGENSTFKALEVAQHLLTTGEAESVLVGAVDLAGGLENVLLRSQQTPMNTGTQTLSFDAKVHGLTVGEGAGAVVLQKYDPKATKKVYAVVDAIAFAQKHALGVADAGTIKQVSNHAFAVAGIKPDAVNYLEVSASGISQADTAEIQGLVQAYPGSENRLSCAVGSVKSNIGHTFTASGIASFIKTALCLYHRYIPGTPQWSGVKEQEQWHGSPFYVAPTSRPWLLSKHTTRRVAAINGIGADGSYAHLIVSEAEQQGERQSRYLQQMPLYLFPLAGDSKEELLTQLDALKSTVQNSTHLQNSASLSFTQFQQKATAKYTLVILGRNHKELLREMESAAKGVTNAFEKGEPWQTPIGSYFTPKPLGKTGEIAYVYPAAINAYVGIAQNIGRLYPQVHDDAMITSLYTAVDDIEKFLYPRSLNKLSTRQLENLEKELLDNSLAMFETEICIARLLTTIIRDRFQAKPKFAFGYSLGETSMMFAQGVWSDFNEGIKKFHASPLFGDRVSGQKNALREYWKLPSFAESPADDFWSTHVLIAKPEQVREAIKNETRVYLTQISTPEEVVIAGEPGGCQRVIKALGCNAFAAPFNHLIHCEAMQSEYNEIVRVNNLPAQPVGDIAFYSSAEYTPVALEGNAIAQSIGKCLTTPLDFPRLVNQIYSQGARIFIEAGAGNVCSRWIDKILENQEHVTVSLNRRGTDDHSSIVRALAKLTSHRVNLDLSSLYNCETATTKKTSYKTITLGGASITGAILTEDNKKLFQDVLKKQHSQAVIPQLPAKSLIPVSEVVNLPEITSQKTNEGDIFSTTKKPEQKLEKVTMKHDINNSYAAKEQLQFCELDVKQHQTPQLIPQSQQSHYPSTTLHFQKLSQNNSRVHKTHATFLQSRQDFSHSISEIIQLQIACAENLLNE
>NC_019751.1|WP_015197376.1|2002464_2004132_-|PfaD-family-polyunsaturated-fatty-acid/polyketide-biosynthesis-protein
MKTVDTVTNPRDNGLKFNTFSFYQNQVWKGSTDCISFDQNSIKEKLLNLNQPCYVVRVDGRIGIANGGYAAPQDDAKTGEVELITAVPPIKIQNLGDPNFLSFYGTKYAYMTGAMAGGIASAEMIIALGKAKLMGSFGAGGLTPSRLEAAINQIQSALINEPYCFNLIHSPNDLAIERRAVDLYLKYGVRVVEASAFLDLTPNIVYYRAAGLGLNSANEIEIRNKVIAKVSRREVATKFLQPAPIKILQDLVNQGLISELQANLAARLPVADDITVEADSGGHTDNRPLVCLLPSMLALRDEIQAKYQYEKPIRIGVAGGISNPQSALAGLMMGAAYIVTGSVNQSCVESGSCEHTKKLLAQAEMADMMMAPAADMFEMGVKLQVLKRGTMFPMRAQKLYELYRTYDSIDDIPMAEREKLEKQIFRQSLSEVWEGTVSYLSQTNPEKLAKAVNNPKLKMAAIFKWYLGLSSRWSSSGEKGREVDYQIWCGPAMGSFNEWVKGTYLEEANNRLVVDVANQIMSGAAYLYRVQSLRVQGLQIGDCYGQFYPQVSSLE
>NC_019751.1|WP_015197375.1|2000751_2002263_-|NAD-dependent-epimerase/dehydratase-family-protein
MVSPKKSMTAEEIQVWMAGKLAELLKVEVDEVDVNLPLEDYGLDSARAMVLVGQVEKKLGVELSPVLLWHYPTIAALSVRLAEDSEDVSDAKSTGVSVVKPLDISVDLGAEVVLDPSIYPAKNSFRFNGEPENVFVTGATGFLGGFIIYELLKQTSCDVYCLVRAANTEAGKIKLKKNLEQYAIWDDEFEPRIIPILGDLSQPLLGISQEGFEMLAANMDAIYHSAATLNYVYPYSALKTANVLGTQEVLRMACMIRVKPVHYVSSVAVFESSAYAGKIVKEDDAFEHWQGIFLGYSQTKWVAEKLVKAASDRGLPVTIHRPPLIGGDSQTGVCNGDDFINLMIKGCIQMGAFPDVDYKMDFSPVDYVSKAIVHLSRQKESLGKAFHLQHPQPVPLKELVEWISSFGFSVKSIPYKEWQQKLTEITDNSNPLYTLRPFLLERWSKEQLTIPDLYLQTQRPIISCQATLHALSGSGVSCPPIDSRLFMTYSAYLIQSGFLSFGS
>NC_019751.1|WP_015197386.1|2026795_2027065_+|hypothetical-protein
MLSHNADPHLLNLLMNADLEQINQALILRLVTENCGFKHRIDTLESQNEEILQKLDNLENIYNEIPYLRHLVDQNEELQNLVDFYCPPD
>NC_019751.1|WP_015197387.1|2027326_2027773_+|nucleotidyltransferase-domain-containing-protein
MNTPTIEKLKQLAQQIPEKIPYLKMLVLFGSRATGETHVNSDWDFAVLIDKAQQEIYTKDNAWGAFGLSMFIGEILNINPDKIDIVELNHCSWLIAHFVARDGILIFEKESSGFEYFRLTSLRPESELKKFRKEQHQLIEMQLKQWSI
>NC_019751.1|WP_015197388.1|2027769_2028213_+|DUF86-domain-containing-protein
MSKIDPEIVLARLRLITKYKNTLEEFRSININEFLAEFRQQLIVERLLQLMIQAAIDINDHILSRLNPGNSATNFEAFIELGKYEVITSELAKQLAPSGSLRNRLVHEYDDIDPNQVYQAIKFALQQYPLYVQQINAYLISLDTESS
>NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein
MNKPTSEEYINLLVEVKQRIRSAQYEALKAVNKELIALYWDIGKMIVTRQEGATWGKSVVEQLAKDLQNEFPGISGFSTANLWRMRLFYDTFANNEKLAPMVREIGWTHNLVILEKCKDDLEREFYIRMTRKFGWTKNVLIHQIENQTYEKTLLNQTNFNQTVSEEIRNQAKLAVKDEYTFDFLELADEHSERQLEQAILTRVEPFLKEMGGMFAFIGSQYRLEIDDEEYFIDILLYHRILKCLIAVELKIGKFLPEYIGKMQFYLAALDDKVRQPDENPSIGIILCKSKNKTIVEYALRESNKPIGVATYQIVSTVPQELINQLPEPEQVAKLLQGIE
>NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3
MAKKTKKSEESKQLSLFESGLDLNSEITDEADDNWLEGDFGFDGDSDRTIETKSELLTLKLLREAIKAQNPDDQVMADFGEYVLPNLLSIAIGVTAKGGKFFDEIDEKREAEGKAKVRRDNAADQSLNTHLLNGLFPANLIERRLHKLDTTVQRVVRERERRLVIAGFILHDFEKFPDVPNDCRKLPLEEHRQIIDEKVRQLGLDKFIDSENTEAYKEYIDDLLCMAYNAQRRWDTNWNFSEFGLNPLLKDRTLRSLSDLTCLADSLASIIKHPQDAENPRLNEIIHSLSDGKLKFTYHRISENRGVLTNVVNNALIQVHTKLNTDENIYYEPLLYLPTGVIYLARRDAPEISLDDVPNQVIENIKSLCSGQLKLRQTGFGRDGKGMKYAEYYNLFFDEIGLMKVALDATLRILNPNKDSVAKSRSDNLVKFQQQKVLSVDYDFKFTDDIRIDQIAEFGDLICRKIWDESANRIEVACKKDKNLPKLTQLDLTYKVAEFWELAEYLPQIREIQRINESLKENKLKGNTGGVPYEWYYLAAKFLEKHPGIENVRESCQQVIEYINNLISPIISQYELPDGWNDLRLWVKQVVMLPGNQETQTPDNFLNELANYNAAKKSGRGRQLICSISHSAYTVTEQMESAVLFTPQVYTNKQMLNGSNAKRNISSIAGLEMMLRQILMNQTQAVGKRFEDGKYRYLYFYPTYYFTPETNKFLQKAYTGISQTRFDTRIRNHFISKDLQANFDKDTYQNVDAFLIDENLDSDKDRTFKLSYPDDQPLTFYFMAMPPGRDSSDTESWVMPTWLAFAFPMILDVKTVVSESPIPPFNDGAEFEESVFLDSAPHAFRTLVGRDRFRLDYILEGWTENNKSYPAPLNVLTAAYAIHIDVNAKSGKSGYDANWGRFTELAKDFETTPLYVFAYLNRWVRSQGVETARIEKIRLYAHKFYPCFDPYAQYDFESKEWKLMPESQLNHPKKLTDLYRKFYRANKRYNPKSNAVLKPIDIAAETILKAEVSVFSGETLVAAVAAEVFKLMDRVHANTADGRWVMSKREEERQAVLDFARYFVMDVFENSFSSDRARLAGRQLNLIKDTCEFLYRLEDDKENANKDVKEEENDKNED
>NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2
MSFLKTVDAKFFHSEIPYKPMGKYVHFLTVRVTESYPLFQTDSELNKARVRAGIVDKTTISRLSMFKRKQSTPERLVGRELLRNYGLMTAEECEYNVKFAMNNPDCIIYGFAIGDSGSEKSKVVVDTAFSIKSFDESHETFTLNAPFENGTMASKGENGSKVGEVTSRINQQDHIKPQVFFPSIVTLKDPTEASFLYVFNNILRTRHYGAQTTRTGRVRNELIGVIFADGEIVSNLRWTQAIYDQMKSNNTLNSPDPLNEDEVFVSAKVSISTLMEDEFIVHEDFLGDKFAALLKEVKAITANEEELKKMLKKADDEAKAYAKVHIKGKDKEKDKDKAAAK
>NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1
MTIIYRCQIELHDSVYYATREIGRLYETEPIIHNYALCYALGLVDSEKYATTVSEEHSYRYFCPEQVPKYEEHLTPLNKQGIYVTPACSISHTSILNTWKYANNNYHVEMEKTQKNIPSFGRAKEIAPESVFEFLIISQNELKLPKWIRLGKWMSKAEVTVEKLPEPKTKTDLFICTHPLNPLDVMFTNQVISYDVINMPPVSLIQNVQMRGQYYYFENVKDVRLPVNISYRFRN
>NC_019751.1|WP_015197393.1|2034943_2035783_+|CRISPR-associated-endoribonuclease-Cas6
MPYSLILNILPQSTIYPNYLTGRHYHALFLSLISSVDRSLGDKLHDSTADKAFTLSPLQVSDRIHHNYPKKTPRSNLLQVNQNEPIPPGTPCWWRISLLDDTLFSKLTPLWLDINPKQPWLLGSADLFITSILATLRQTQPWANACSYHQLYEQASESDRILNFLFSTPVCFRQGSYDSCLPTRESVFNSLLRSWNKYAGLEFLESKLDTIFPNFFNIKTDIVSDSRSKFIGCIGEISYRIMGDIEPIEIKQLNTLADFAIYAGIGRKTTMGMGMVRRI
>NC_019751.1|WP_015197394.1|2035825_2036416_+|CRISPR-associated-protein-Cas4
MKNEEYIPIAALNQYTYCPHRCWRIHCAGEFTDNQYTIEGTSLHDRVHTVGEGNRDEIWQVRAIWLKSEQYKLIGKSDLIELENSGWLPVEYKRGKKGEWDNDELQVCAQALCLEEMTGKHIQTGYVYYAQTHQRQLIEINPELRRQTINTITDVTRLLVTGAMPQAIYSNRCKGCSLYEQCLPKATEKVGKYCED
>NC_019751.1|WP_015197395.1|2036526_2037531_+|type-I-D-CRISPR-associated-endonuclease-Cas1
MGTVYVTQDDAFIGKVDERLHVRIEKKTILDVPLIKIDGLVVMGRASISPMAIMELIQNKIPLTFLTINGKYIARLEPEMSKNIFLRNAQWKAAGDSSQAIHVTKAFVRGKLKNYRYALLRLQRSYLEHDLSQSLIQLKQSIESLEKVNNIDSIRGYEGAGSAVYFGCFDKFIRVDNFSFKNRNRRPPVDPVNSLLSLGYSLLRHDIQSALNIVGFDPYLGYLHVERYGRPSLALDLMEEFRPLIVDAVVINSINKKILKPSDFITEPVSNAVSLTKEGLHTFLKLYQEKKQAKFKHPVLGIQKTYQESFEVQARLLGKYLMGEIDKYPPLIMK

Crispr_ID: NC_019751_9

• CRISPR_ID: NC_019751_9
• CRISPR_location: 2038085-2039287
• CRISPR_type: TypeI-D
• Repeat_type: I-D,II-B
• Spacer_info: 16 spacers
• Cas_protein_info: cas2,cas1,cas4,cas6,csc1gr5,csc2gr7,cas10d,PD-DExK

Consensus repeat of NC_019751_9

Consensus_repeat	Method
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	PILER-CR
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CRISPRCasFinder
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CRT

spacers of NC_019751_9

>9.1|2038122|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
AGATATACGCTCAATCATCATCATAATTTCCTTTT
>9.2|2038194|40|NC_019751|PILER-CR,CRISPRCasFinder,CRT
ATTTTAAAGCAGGCGCTAGAATTAGCAGAAGCAAAATCAC
>9.3|2038271|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TCAAACCTTAAATCGGTTGCTATCAGCATATATT
>9.4|2038342|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CTAGTAGGAACTACCAACGAGTCGGAAATTTTAAA
>9.5|2038414|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
TTAGCGAATGTGACCGAAGAATTGAGCGACGAACT
>9.6|2038486|37|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CAACTAAATCCCCAATCATCCTGTTTTGTTGTTGGGT
>9.7|2038560|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT
GCGTCCTCAATAACTTTTGTAAATGCGGCTTTTT
>9.8|2038631|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CTCTGGTCGCTACCTGGCGCTGCGCGCCAGGTCA
>9.9|2038702|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CTAAAACCTTTTTAGGTCAAGCCGTTACAGGACTTA
>9.10|2038775|38|NC_019751|PILER-CR,CRISPRCasFinder,CRT
ATATGCGATCGCGCCAAATCTCAAAGTAGGATCTTCAC
>9.11|2038850|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CAAGCTTTGTACAACTTCAAGAAAAATCAAATAGTT
>9.12|2038923|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
GGACGAAGGCAGCTTCGACGGATTACTAAGTGCATT
>9.13|2038996|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CGCAGTTACTGTTCCCCTGCGAAAAGTCAACGTGGA
>9.14|2039069|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CTAATATCTTGATCACATCCTCCACCAATAGCAG
>9.15|2039140|39|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CGAGGTATGCAGCTATAGACCCGCTGCGTCCTCTGTTCC
>9.16|2039216|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT
CTTTATTCGATGAAATTTTCTGGGCTGAAGGTACT

CRISPR arrays and Neighbor proteins around NC_019751_9

CRISPR arrays

The CRISPR arrays of NC_019751_9

>merge|NC_019751|9|2038085-2039287|PILER-CR,CRISPRCasFinder,CRT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACAGATATACGCTCAATCATCATCATAATTTCCTTTTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACATTTTAAAGCAGGCGCTAGAATTAGCAGAAGCAAAATCACGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACTCAAACCTTAAATCGGTTGCTATCAGCATATATTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCTAGTAGGAACTACCAACGAGTCGGAAATTTTAAAGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACTTAGCGAATGTGACCGAAGAATTGAGCGACGAACTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCAACTAAATCCCCAATCATCCTGTTTTGTTGTTGGGTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACGCGTCCTCAATAACTTTTGTAAATGCGGCTTTTTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCTCTGGTCGCTACCTGGCGCTGCGCGCCAGGTCAGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCTAAAACCTTTTTAGGTCAAGCCGTTACAGGACTTAGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACATATGCGATCGCGCCAAATCTCAAAGTAGGATCTTCACGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCAAGCTTTGTACAACTTCAAGAAAAATCAAATAGTTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACGGACGAAGGCAGCTTCGACGGATTACTAAGTGCATTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCGCAGTTACTGTTCCCCTGCGAAAAGTCAACGTGGAGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCTAATATCTTGATCACATCCTCCACCAATAGCAGGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCGAGGTATGCAGCTATAGACCCGCTGCGTCCTCTGTTCCGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAACCTTTATTCGATGAAATTTTCTGGGCTGAAGGTACTGTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC

>NC_019751|9|6|2038085-2039287|PILER-CR
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGATATACGCTCAATCATCATCATAATTTCCTTTT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	ATTTTAAAGCAGGCGCTAGAATTAGCAGAAGCAAAATCAC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	TCAAACCTTAAATCGGTTGCTATCAGCATATATT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTAGTAGGAACTACCAACGAGTCGGAAATTTTAAA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	TTAGCGAATGTGACCGAAGAATTGAGCGACGAACT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CAACTAAATCCCCAATCATCCTGTTTTGTTGTTGGGT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	GCGTCCTCAATAACTTTTGTAAATGCGGCTTTTT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTCTGGTCGCTACCTGGCGCTGCGCGCCAGGTCA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTAAAACCTTTTTAGGTCAAGCCGTTACAGGACTTA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	ATATGCGATCGCGCCAAATCTCAAAGTAGGATCTTCAC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CAAGCTTTGTACAACTTCAAGAAAAATCAAATAGTT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	GGACGAAGGCAGCTTCGACGGATTACTAAGTGCATT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CGCAGTTACTGTTCCCCTGCGAAAAGTCAACGTGGA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTAATATCTTGATCACATCCTCCACCAATAGCAG
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CGAGGTATGCAGCTATAGACCCGCTGCGTCCTCTGTTCC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTTTATTCGATGAAATTTTCTGGGCTGAAGGTACT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC

>NC_019751|9|9|2038085-2039287|CRISPRCasFinder
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGATATACGCTCAATCATCATCATAATTTCCTTTT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	ATTTTAAAGCAGGCGCTAGAATTAGCAGAAGCAAAATCAC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	TCAAACCTTAAATCGGTTGCTATCAGCATATATT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTAGTAGGAACTACCAACGAGTCGGAAATTTTAAA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	TTAGCGAATGTGACCGAAGAATTGAGCGACGAACT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CAACTAAATCCCCAATCATCCTGTTTTGTTGTTGGGT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	GCGTCCTCAATAACTTTTGTAAATGCGGCTTTTT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTCTGGTCGCTACCTGGCGCTGCGCGCCAGGTCA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTAAAACCTTTTTAGGTCAAGCCGTTACAGGACTTA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	ATATGCGATCGCGCCAAATCTCAAAGTAGGATCTTCAC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CAAGCTTTGTACAACTTCAAGAAAAATCAAATAGTT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	GGACGAAGGCAGCTTCGACGGATTACTAAGTGCATT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CGCAGTTACTGTTCCCCTGCGAAAAGTCAACGTGGA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTAATATCTTGATCACATCCTCCACCAATAGCAG
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CGAGGTATGCAGCTATAGACCCGCTGCGTCCTCTGTTCC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTTTATTCGATGAAATTTTCTGGGCTGAAGGTACT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC

>NC_019751|9|6|2038085-2039287|CRT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	AGATATACGCTCAATCATCATCATAATTTCCTTTT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	ATTTTAAAGCAGGCGCTAGAATTAGCAGAAGCAAAATCAC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	TCAAACCTTAAATCGGTTGCTATCAGCATATATT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTAGTAGGAACTACCAACGAGTCGGAAATTTTAAA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	TTAGCGAATGTGACCGAAGAATTGAGCGACGAACT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CAACTAAATCCCCAATCATCCTGTTTTGTTGTTGGGT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	GCGTCCTCAATAACTTTTGTAAATGCGGCTTTTT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTCTGGTCGCTACCTGGCGCTGCGCGCCAGGTCA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTAAAACCTTTTTAGGTCAAGCCGTTACAGGACTTA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	ATATGCGATCGCGCCAAATCTCAAAGTAGGATCTTCAC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CAAGCTTTGTACAACTTCAAGAAAAATCAAATAGTT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	GGACGAAGGCAGCTTCGACGGATTACTAAGTGCATT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CGCAGTTACTGTTCCCCTGCGAAAAGTCAACGTGGA
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTAATATCTTGATCACATCCTCCACCAATAGCAG
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CGAGGTATGCAGCTATAGACCCGCTGCGTCCTCTGTTCC
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC	CTTTATTCGATGAAATTTTCTGGGCTGAAGGTACT
GTTCCTATAAACTAAAATCCCTATCAGGGATTGAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015197388.1|2027769_2028213_+|DUF86-domain-containing-protein	unknown	unknown	gnl|CDD|366864
NC_019751.1|WP_015197387.1|2027326_2027773_+|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|376187
NC_019751.1|WP_015197396.1|2037552_2037825_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_019751.1|WP_015197401.1|2044914_2045898_+|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223528
NC_019751.1|WP_015197395.1|2036526_2037531_+|type-I-D-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl|CDD|274976
NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	gnl|CDD|187842
NC_019751.1|WP_015197405.1|2049304_2049766_+|DUF2141-domain-containing-protein	unknown	unknown	gnl|CDD|227048
NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	gnl|CDD|375747
NC_019751.1|WP_015197407.1|2051629_2053012_+|amino-acid-permease	unknown	unknown	gnl|CDD|273332
NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein	PD-DExK	COG4804_PD-DExK_CAS-I:CAS-III	gnl|CDD|377634
NC_019751.1|WP_015197394.1|2035825_2036416_+|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl|CDD|187768
NC_019751.1|WP_015197406.1|2049900_2051154_+|glycosyltransferase	unknown	unknown	gnl|CDD|340842
NC_019751.1|WP_015197397.1|2039319_2039853_-|beta-ketoacyl-synthase	unknown	unknown	gnl|CDD|274311
NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	cas10d	cd09712_cas10d_CAS-I-D	gnl|CDD|274469
NC_019751.1|WP_015197404.1|2047159_2049097_+|glycosyltransferase	unknown	unknown	gnl|CDD|340844
NC_019751.1|WP_015197398.1|2040308_2040587_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197393.1|2034943_2035783_+|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl|CDD|227838
NC_019751.1|WP_015197399.1|2041247_2042540_-|ParB-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|319266
NC_019751.1|WP_015197400.1|2043480_2044689_+|ABC-exporter-membrane-fusion-protein	unknown	unknown	gnl|CDD|213754
NC_019751.1|WP_015197403.1|2046000_2046999_+|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|366154

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein	PD-DExK	COG4804_PD-DExK_CAS-I:CAS-III	2.3e-45	149.0	6.6
NC_019751.1|WP_015197396.1|2037552_2037825_+|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.6e-31	103.1	0.1
NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	1.2e-103	340.9	0.1
NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	cas10d	cd09712_cas10d_CAS-I-D	0	1063.7	2.1
NC_019751.1|WP_015197395.1|2036526_2037531_+|type-I-D-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	4.5e-100	329.7	0.0
NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	6.7e-85	278.6	2.6
NC_019751.1|WP_015197393.1|2034943_2035783_+|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	4.3e-58	191.6	0.0
NC_019751.1|WP_015197394.1|2035825_2036416_+|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	8.2e-48	157.6	0.7

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015197388.1|2027769_2028213_+|DUF86-domain-containing-protein	gnl|CDD|366864	pfam01934, DUF86, Protein of unknown function DUF86. The function of members of this family is unknown.	7.18677e-19
NC_019751.1|WP_015197387.1|2027326_2027773_+|nucleotidyltransferase-domain-containing-protein	gnl|CDD|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	1.72919e-17
NC_019751.1|WP_015197396.1|2037552_2037825_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.39949e-36
NC_019751.1|WP_015197401.1|2044914_2045898_+|NAD(P)-dependent-oxidoreductase	gnl|CDD|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	9.68938e-44
NC_019751.1|WP_015197395.1|2036526_2037531_+|type-I-D-CRISPR-associated-endonuclease-Cas1	gnl|CDD|274976	TIGR04093, hypothetical_protein_L8106_25395, CRISPR-associated endonuclease Cas1, subtype CYANO. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes a clade of Cas1 limited to the CYANO subtype of CRISPR/Cas system and most often the type found there.	1.77967e-142
NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1	gnl|CDD|187842	cd09711, Csc1_I-D, CRISPR/Cas system-associated protein Csc1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas5 ortholog; also known as CasA/Cse1 family.	5.80994e-87
NC_019751.1|WP_015197405.1|2049304_2049766_+|DUF2141-domain-containing-protein	gnl|CDD|227048	COG4704, COG4704, Uncharacterized protein conserved in bacteria [Function unknown].	5.37484e-44
NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2	gnl|CDD|375747	pfam18320, Csc2, Csc2 Crispr. The Csc2 Crispr family of proteins forms a core RNA recognition motif-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	6.24537e-172
NC_019751.1|WP_015197407.1|2051629_2053012_+|amino-acid-permease	gnl|CDD|273332	TIGR00911, High-affinity_methionine_permease, L-type amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	4.22601e-57
NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein	gnl|CDD|377634	pfam06250, DUF1016, Protein of unknown function (DUF1016). Family of uncharacterized proteins found in viruses, archaea and bacteria.	8.32594e-84
NC_019751.1|WP_015197394.1|2035825_2036416_+|CRISPR-associated-protein-Cas4	gnl|CDD|187768	cd09637, Cas4_I-A_I-B_I-C_I-D_II-B, CRISPR/Cas system-associated protein Cas4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster.	1.70228e-50
NC_019751.1|WP_015197406.1|2049900_2051154_+|glycosyltransferase	gnl|CDD|340842	cd03814, GT4-like, glycosyltransferase family 4 proteins. This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.	1.58903e-59
NC_019751.1|WP_015197397.1|2039319_2039853_-|beta-ketoacyl-synthase	gnl|CDD|274311	TIGR02813, omega-3_polyunsaturated_fatty_acid_synthase_PfaA, polyketide-type polyunsaturated fatty acid synthase PfaA. Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.	1.12605e-58
NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	gnl|CDD|274469	TIGR03174, cas_Csc3, CRISPR type I-D/CYANO-associated protein Csc3/Cas10d. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. This family is designated Csc3 for CRISPR/Cas Subtype Cyano protein 3, as it is often the third gene upstream of the core cas genes, cas3-cas4-cas1-cas2.	0
NC_019751.1|WP_015197404.1|2047159_2049097_+|glycosyltransferase	gnl|CDD|340844	cd03817, GT4_UGDG-like, UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.	6.51807e-19
NC_019751.1|WP_015197393.1|2034943_2035783_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.28894e-44
NC_019751.1|WP_015197399.1|2041247_2042540_-|ParB-N-terminal-domain-containing-protein	gnl|CDD|319266	cd16409, ParB_N_like, ParB N-terminal-like domain of bacterial and plasmid parABS partitioning systems. This family represents the N-terminal domain of ParB, a DNA-binding component of the prokaryotic parABS partitioning system. parABS contributes to the efficient segregation of chromosomes and low-copy number plasmids to daughter cells during prokaryotic cell division. The process includes the parA (Walker box) ATPase, the ParB DNA-binding protein and a parS cis-acting DNA sites. Binding of ParB to centromere-like parS sites is followed by non-specific binding to DNA ("spreading", which has been implicated in gene silencing in plasmid P1) and oligomerization of additional ParB molecules near the parS sites. It has been proposed that ParB-ParB cross-linking compacts the DNA, binds to parA via the N-terminal region, and leads to parA separating the ParB-parS complexes and the recruitment of the SMC (structural maintenance of chromosomes) complexes. The ParB N-terminal domain of Bacillus subtilis and other species contains a Arginine-rich ParB Box II with residues essential for bridging of the ParB-parS complexes. The arginine-rich ParB Box II consensus (I[VIL]AGERR[FYW]RA[AS] identified in several species is partially conserved with this family and related families. Mutations within the basic columns particularly debilitate spreading from the parS sites and impair SMC recruitment. The C-terminal domain contains a HTH DNA-binding motif and is the primary homo-dimerization domain, and binds to parS DNA sites. Additional homo-dimerization contacts are found along the N-terminal domain, but dimerization of the N-terminus may only occur after concentration at ParB-parS foci.	2.16639e-21
NC_019751.1|WP_015197400.1|2043480_2044689_+|ABC-exporter-membrane-fusion-protein	gnl|CDD|213754	TIGR02971, devB-like_secretion_protein, ABC exporter membrane fusion protein, DevB family. Members of this protein family are found mostly in the Cyanobacteria, but also in the Planctomycetes. DevB from Anabaena sp. strain PCC 7120 is partially characterized as a membrane fusion protein of the DevBCA ABC exporter, probably a glycolipid exporter, required for heterocyst formation. Most Cyanobacteria have one member only, but Nostoc sp. PCC 7120 has seven members.	1.30508e-98
NC_019751.1|WP_015197403.1|2046000_2046999_+|glycosyltransferase-family-2-protein	gnl|CDD|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	4.45322e-33

Protein sequences

>NC_019751.1|WP_015197396.1|2037552_2037825_+|CRISPR-associated-endonuclease-Cas2
MFVVVSYDIPEDKRRTKIHNTLKSYGQWMQYSLFECDLTDTQYAKLRSRLSKLIKPQEDSVRFYFLCACCKGKVERIGGEMPRNDTMFFI
>NC_019751.1|WP_015197395.1|2036526_2037531_+|type-I-D-CRISPR-associated-endonuclease-Cas1
MGTVYVTQDDAFIGKVDERLHVRIEKKTILDVPLIKIDGLVVMGRASISPMAIMELIQNKIPLTFLTINGKYIARLEPEMSKNIFLRNAQWKAAGDSSQAIHVTKAFVRGKLKNYRYALLRLQRSYLEHDLSQSLIQLKQSIESLEKVNNIDSIRGYEGAGSAVYFGCFDKFIRVDNFSFKNRNRRPPVDPVNSLLSLGYSLLRHDIQSALNIVGFDPYLGYLHVERYGRPSLALDLMEEFRPLIVDAVVINSINKKILKPSDFITEPVSNAVSLTKEGLHTFLKLYQEKKQAKFKHPVLGIQKTYQESFEVQARLLGKYLMGEIDKYPPLIMK
>NC_019751.1|WP_015197394.1|2035825_2036416_+|CRISPR-associated-protein-Cas4
MKNEEYIPIAALNQYTYCPHRCWRIHCAGEFTDNQYTIEGTSLHDRVHTVGEGNRDEIWQVRAIWLKSEQYKLIGKSDLIELENSGWLPVEYKRGKKGEWDNDELQVCAQALCLEEMTGKHIQTGYVYYAQTHQRQLIEINPELRRQTINTITDVTRLLVTGAMPQAIYSNRCKGCSLYEQCLPKATEKVGKYCED
>NC_019751.1|WP_015197393.1|2034943_2035783_+|CRISPR-associated-endoribonuclease-Cas6
MPYSLILNILPQSTIYPNYLTGRHYHALFLSLISSVDRSLGDKLHDSTADKAFTLSPLQVSDRIHHNYPKKTPRSNLLQVNQNEPIPPGTPCWWRISLLDDTLFSKLTPLWLDINPKQPWLLGSADLFITSILATLRQTQPWANACSYHQLYEQASESDRILNFLFSTPVCFRQGSYDSCLPTRESVFNSLLRSWNKYAGLEFLESKLDTIFPNFFNIKTDIVSDSRSKFIGCIGEISYRIMGDIEPIEIKQLNTLADFAIYAGIGRKTTMGMGMVRRI
>NC_019751.1|WP_015197392.1|2033776_2034484_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1
MTIIYRCQIELHDSVYYATREIGRLYETEPIIHNYALCYALGLVDSEKYATTVSEEHSYRYFCPEQVPKYEEHLTPLNKQGIYVTPACSISHTSILNTWKYANNNYHVEMEKTQKNIPSFGRAKEIAPESVFEFLIISQNELKLPKWIRLGKWMSKAEVTVEKLPEPKTKTDLFICTHPLNPLDVMFTNQVISYDVINMPPVSLIQNVQMRGQYYYFENVKDVRLPVNISYRFRN
>NC_019751.1|WP_015197391.1|2032745_2033771_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2
MSFLKTVDAKFFHSEIPYKPMGKYVHFLTVRVTESYPLFQTDSELNKARVRAGIVDKTTISRLSMFKRKQSTPERLVGRELLRNYGLMTAEECEYNVKFAMNNPDCIIYGFAIGDSGSEKSKVVVDTAFSIKSFDESHETFTLNAPFENGTMASKGENGSKVGEVTSRINQQDHIKPQVFFPSIVTLKDPTEASFLYVFNNILRTRHYGAQTTRTGRVRNELIGVIFADGEIVSNLRWTQAIYDQMKSNNTLNSPDPLNEDEVFVSAKVSISTLMEDEFIVHEDFLGDKFAALLKEVKAITANEEELKKMLKKADDEAKAYAKVHIKGKDKEKDKDKAAAK
>NC_019751.1|WP_015197390.1|2029275_2032632_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3
MAKKTKKSEESKQLSLFESGLDLNSEITDEADDNWLEGDFGFDGDSDRTIETKSELLTLKLLREAIKAQNPDDQVMADFGEYVLPNLLSIAIGVTAKGGKFFDEIDEKREAEGKAKVRRDNAADQSLNTHLLNGLFPANLIERRLHKLDTTVQRVVRERERRLVIAGFILHDFEKFPDVPNDCRKLPLEEHRQIIDEKVRQLGLDKFIDSENTEAYKEYIDDLLCMAYNAQRRWDTNWNFSEFGLNPLLKDRTLRSLSDLTCLADSLASIIKHPQDAENPRLNEIIHSLSDGKLKFTYHRISENRGVLTNVVNNALIQVHTKLNTDENIYYEPLLYLPTGVIYLARRDAPEISLDDVPNQVIENIKSLCSGQLKLRQTGFGRDGKGMKYAEYYNLFFDEIGLMKVALDATLRILNPNKDSVAKSRSDNLVKFQQQKVLSVDYDFKFTDDIRIDQIAEFGDLICRKIWDESANRIEVACKKDKNLPKLTQLDLTYKVAEFWELAEYLPQIREIQRINESLKENKLKGNTGGVPYEWYYLAAKFLEKHPGIENVRESCQQVIEYINNLISPIISQYELPDGWNDLRLWVKQVVMLPGNQETQTPDNFLNELANYNAAKKSGRGRQLICSISHSAYTVTEQMESAVLFTPQVYTNKQMLNGSNAKRNISSIAGLEMMLRQILMNQTQAVGKRFEDGKYRYLYFYPTYYFTPETNKFLQKAYTGISQTRFDTRIRNHFISKDLQANFDKDTYQNVDAFLIDENLDSDKDRTFKLSYPDDQPLTFYFMAMPPGRDSSDTESWVMPTWLAFAFPMILDVKTVVSESPIPPFNDGAEFEESVFLDSAPHAFRTLVGRDRFRLDYILEGWTENNKSYPAPLNVLTAAYAIHIDVNAKSGKSGYDANWGRFTELAKDFETTPLYVFAYLNRWVRSQGVETARIEKIRLYAHKFYPCFDPYAQYDFESKEWKLMPESQLNHPKKLTDLYRKFYRANKRYNPKSNAVLKPIDIAAETILKAEVSVFSGETLVAAVAAEVFKLMDRVHANTADGRWVMSKREEERQAVLDFARYFVMDVFENSFSSDRARLAGRQLNLIKDTCEFLYRLEDDKENANKDVKEEENDKNED
>NC_019751.1|WP_015197389.1|2028231_2029251_+|DUF1016-domain-containing-protein
MNKPTSEEYINLLVEVKQRIRSAQYEALKAVNKELIALYWDIGKMIVTRQEGATWGKSVVEQLAKDLQNEFPGISGFSTANLWRMRLFYDTFANNEKLAPMVREIGWTHNLVILEKCKDDLEREFYIRMTRKFGWTKNVLIHQIENQTYEKTLLNQTNFNQTVSEEIRNQAKLAVKDEYTFDFLELADEHSERQLEQAILTRVEPFLKEMGGMFAFIGSQYRLEIDDEEYFIDILLYHRILKCLIAVELKIGKFLPEYIGKMQFYLAALDDKVRQPDENPSIGIILCKSKNKTIVEYALRESNKPIGVATYQIVSTVPQELINQLPEPEQVAKLLQGIE
>NC_019751.1|WP_015197388.1|2027769_2028213_+|DUF86-domain-containing-protein
MSKIDPEIVLARLRLITKYKNTLEEFRSININEFLAEFRQQLIVERLLQLMIQAAIDINDHILSRLNPGNSATNFEAFIELGKYEVITSELAKQLAPSGSLRNRLVHEYDDIDPNQVYQAIKFALQQYPLYVQQINAYLISLDTESS
>NC_019751.1|WP_015197387.1|2027326_2027773_+|nucleotidyltransferase-domain-containing-protein
MNTPTIEKLKQLAQQIPEKIPYLKMLVLFGSRATGETHVNSDWDFAVLIDKAQQEIYTKDNAWGAFGLSMFIGEILNINPDKIDIVELNHCSWLIAHFVARDGILIFEKESSGFEYFRLTSLRPESELKKFRKEQHQLIEMQLKQWSI
>NC_019751.1|WP_015197397.1|2039319_2039853_-|beta-ketoacyl-synthase
MSASWLNNALAQLEEHINNCEQAVIKHIEEKKRMSDKSVPVNPMNTKLQHNPIAIVGMASLLPQSRNMREYWENIIKKIDCITDIPDSHWNVDEYYDPNPRTPEDKTYCKRGGFIPYVDFNPMEFGLPPNILEVTDVSQLLSLVVAKEAMEDAGYGQNNEFNREKVGVVLGVASGKP
>NC_019751.1|WP_015197398.1|2040308_2040587_-|hypothetical-protein
MSFIKIQNIIINTSYIAAIKLDNITSSGENSVSVLIATPRFPLFQLESTSQNLYHQEWVEFTGQAAQALENYFTSFNNVIDLLPAHQQSTTI
>NC_019751.1|WP_015197399.1|2041247_2042540_-|ParB-N-terminal-domain-containing-protein
MSKVVALDIEQIRIGENRRPIKDAKVAELIQSIQANGLLNPITVDQKFNLVAGLHRLTACKLLGSKEIECNVINCSDADGARLAEIDENFVRSELEPLERYELWLERDRILERMGLRAKPGDNQYSRSGGEFISPPPKTTLELAQSLGYSERSFQQGKQIAKDIHPEVKREIVGSSLAKSRTIQLQIARAAAAERMAAEIAEKALELAIQAENHQEAEEQAQLATQARERQKQIQIETLQGAISRKGRRGEGKRGGGEEEGEGEEWVLGRHLVYCGDTASGDFIKKLPGHAALAIATLTQSPWRHDYLVKEARIVAVLRSAGNIYEFFNCQKMPFQYEFIIDDVYVGIFSQQSIPKPQGKINIGGVEGIISYLLGTYTQPNNYVIAPFMGNGEVLLGCDRMSRICFTGDKNPQLVKGGIERYQKFGNKRE
>NC_019751.1|WP_015197400.1|2043480_2044689_+|ABC-exporter-membrane-fusion-protein
MTLDSDRPFFKHKPLFPWHLLIAIPIVLGGIVSSSYGIYKYQFYIQKQSTEPIKITPTKIAVIALGKIVPQGEVTRLSPPSSLSGVRAEKILVKEGQIVKAGQVLAWLEGYKKTAAAVQQSVENVKVARAKLAQIQAGAKIGDINAQKAVISSLQAQLEGEISTQSATITRLAAQVENADAENQRYQMLLQQGAVSVSVADSKRLQMQTVEQELVEGRARLNRSTNILQDQLREARAKLASLSEVRPVDVQLAEAEVKSAIASLQQSQAEHELTYVTTPIAGKLLKVHSKTGEVIGSEGVAQIGKTSQMYVVAEVYQTDLEKVHIAQKAIITSTAFKGKIIGTVSDIGLQVERQSIVSINPSPDSDRRVVKVKIRIDNPQDSQRVSGLTNLQVDVAIQISNQ
>NC_019751.1|WP_015197401.1|2044914_2045898_+|NAD(P)-dependent-oxidoreductase
MTTILITEIDGCIGLRAAEIAVAKGMKVKGILSNSDKVKDFDKSKIDIIVGNITKPDIAKQACQGVDIVLHTAEMAKEGGAIKAFREINVEGTKNIANAAKQAGVKTFVHLSTVLVYGFEYSDRITEAAPLNTQKNPYCQSKIEAEKAIIEYNHPPEFGVIVIRAGDVYGPESIPWIVRPVTLMRQNTFAYANEGKGVMNHLYVDNLIDAIFLAIEKQAYGETFNITDGQETSWKEYFTKLAEIAELTAPFSLPKDEMKLFLQIRHQGQKLFRKEADILPESVDFMTRPHAYSIIKAKDLLDYKPKVSLEEGLQLTKKWLQANVLNN
>NC_019751.1|WP_015197403.1|2046000_2046999_+|glycosyltransferase-family-2-protein
MKNKPRLSIGLPVYNGEKFLRPALDSLLNQTFQDFELIISDNASTDATEAICQEYADKDSRIRYYRNPDNVGCARNFNYVLELASCEYFKWVAYDDLHDSTFIEKCINILDQDPNLILCHSQVQFIDETGRYIQDYNIHIKANLPKAHQRFSELITKHLCYQCYGVIRTKILKNAPRMGSYGAADAIFLLRLALFGRFYEIPEYLFFARHHSQQSLSMFFPEYMSCVDKKPQKIANKLPDFYAYAEWFDTNNKGKLLFPHWRILGEYLRSAWMGKMEWYERLICYFNIIKKLSGTETLLIKDLIVAIGLIWQHIPRVSVSVKVEIRRPSVSI
>NC_019751.1|WP_015197404.1|2047159_2049097_+|glycosyltransferase
MQTTKPLKIVICTDYLGYGAVEGSFSGFQKVITDWISKSTSDPNIQIIVYCLGTEEKVYRAFNSVLFKQYKPHLSNRTILPLVSPHIFPFLLDIFPIHSKIIKDIIHEKPDVIHTFQTFGVTELAGFIAAKIMKMRKQQVTLINTVMCEIDTYAANYMRRVVISFYKIIDSSPFFKIVADSVDGGSYLVKSTNPSRQVRSVLYTISAASAYYLFLNLSLLGQIQDFLVKAVRFIYKLILQKKYPKFESEVKLAMNSIREPFILSRYREKNFSLFKLIAKPFQLVFDFLRRGDELGKQPGLAGILGNTLGVALKQQISLFVNQCDRVTISRHEDIGRYSIKSNIWEVPLGYDTAKFKVYQPNIDELIFKVEKSVAIGNLSAVNAKKLIDFISHPMRINQRCFIYVGRLSDEKNISLLLNACERLLHQDNLQNQVHFLFIGTGFAASEIASTLGSSATIIDFVPNYLLPDIYNFLRQNSGFFISASDTETYGITHGEAAACGLPLIGMERGSRGHFFCPGDKVGKLVIEDEEKIAKSITEIVIESGNNNLMVALNGLYVSDTSYGLGLSRLPVFDLSRILAQESLFVAMYMMALLPDSIYLSMSDCSANLSIHNQFSSDESWELMKYVYVNDWISYNFKLQQKKHIF
>NC_019751.1|WP_015197405.1|2049304_2049766_+|DUF2141-domain-containing-protein
MRFNLLPLLCLTFATTNAFYNPVLAQSTSNMTVVVNGIKSESGRVCFRVYSSDQGFPFSNKSEVQSGCVEKTGSVVKKQFVGLKPGNYAVTVIDDSNRDGKLNTDFLGIPQEGFGVSNNPTVSITTGTPKFSKASFSLNKNTVINIRMKYSLD
>NC_019751.1|WP_015197406.1|2049900_2051154_+|glycosyltransferase
MQKQPLRIAIITSLYAPFLTGVSVAVHQRVNWLLKQGHEVFLIHPEINDKFPQKVSNRPMPSIEENQAFPNFYSFAFPTEPLIFYKSLPQPLNHRHWSDTKLLENFKPDIIIVEEAPQLRGFYSLFLQGYGRPVGIDYARKTGTPIISLFHTDIVAYIRYYLGNQIFNLISLILPGIIKKFSEEYDANFFPSREELKKYQDLKSQRSEYLPYQGVDCQKFQPKNICYNPIPEDKRPTLLFVGRITAEKNVTQLIDIYPLVAAKIPDVHLVIIGSGPLDAEMRTRAEKYVPGITIWGESHGNELLGWYTRADLFVNPSLTENFCTANNEALASGTPVVAAKAPSTAEQVIVGKNGFLAEANDIVDFANKIVEILGNPQLKAEMSKQARLSILPFDWAACSQKFEDKLYEVVEAKKGSE
>NC_019751.1|WP_015197407.1|2051629_2053012_+|amino-acid-permease
MNKRKNYAVVQEATTTINSATAPKQSLAFLDAVALIVGIVIGAGIFQTPAFVAANAGSGINLLILWLLGGAISLVGALCYAELATTYPDVGGTYYYLKLAFGRSVAFLFAWARMTVIQSGSIVLLAFVFGDYFSALWQLGTYSPSIYAAIAIVLLTGLNILGLYPGKWTQNWLTVAKIVGLLLVVVIGVCSNAPLNPATLPTPSTSTNWGLAMVFVLLSFGGWNEAAYISADIKDGKRNIVRSLVWSIGIITVIYLLINFAYLRGLGLTTMAKSEAVAATLMDQTVGKTGSLFLSVLVAICTLGAINATILTGARSNYALGKDFSLFSFMGGWQQQKETPTQALLIQGVIALSLVFLGTITRNGFETMVEYTAPVFWFFFLLSAISLFILRRRDPHIPRPFRVPLYPWTPLLFCIICGYLLYSSLAYTSIGAIVGILVVGAGIPLWVWNGYRGKKYNLRS

Crispr_ID: NC_019751_10

• CRISPR_ID: NC_019751_10
• CRISPR_location: 2237603-2237729
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_10

Consensus_repeat	Method
TAACTGGTGTCACTACTGGTGTAACAGTGGGTGGTACTGT	CRISPRCasFinder

spacers of NC_019751_10

>10.1|2237643|47|NC_019751|CRISPRCasFinder
TCCCCCAGAATTAGGTGTTTTAGTAGAACCACCAGCAGGTTTTGCCA

CRISPR arrays and Neighbor proteins around NC_019751_10

CRISPR arrays

The CRISPR arrays of NC_019751_10

>merge|NC_019751|10|2237603-2237729|CRISPRCasFinder
TAACTGGTGTCACTACTGGTGTAACAGTGGGTGGTACTGTTCCCCCAGAATTAGGTGTTTTAGTAGAACCACCAGCAGGTTTTGCCATAACTGGTGTCACTACTGGTGTAACAGTGGGTGGTACTGT

>NC_019751|10|10|2237603-2237729|CRISPRCasFinder
TAACTGGTGTCACTACTGGTGTAACAGTGGGTGGTACTGT	TCCCCCAGAATTAGGTGTTTTAGTAGAACCACCAGCAGGTTTTGCCA
TAACTGGTGTCACTACTGGTGTAACAGTGGGTGGTACTGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015197568.1|2249078_2249255_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197557.1|2231181_2232912_+|RluA-family-pseudouridine-synthase	unknown	unknown	gnl|CDD|223638
NC_019751.1|WP_015197562.1|2238496_2240071_-|circadian-clock-protein-KaiC	unknown	unknown	gnl|CDD|131703
NC_019751.1|WP_015197569.1|2249406_2250147_+|creatininase-family-protein	unknown	unknown	gnl|CDD|224320
NC_019751.1|WP_015197563.1|2240366_2240690_-|circadian-clock-protein-KaiB	unknown	unknown	gnl|CDD|181770
NC_019751.1|WP_015197554.1|2227503_2227977_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197570.1|2250157_2251117_+|LD-carboxypeptidase	unknown	unknown	gnl|CDD|224534
NC_019751.1|WP_144051017.1|2235997_2236093_+|cytochrome-B6	unknown	unknown	unknown
NC_019751.1|WP_015197559.1|2234440_2234623_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197556.1|2229281_2230973_-|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl|CDD|237137
NC_019751.1|WP_015197555.1|2227984_2228791_+|dienelactone-hydrolase-family-protein	unknown	unknown	gnl|CDD|223489
NC_019751.1|WP_015197560.1|2234771_2235869_-|3-dehydroquinate-synthase	unknown	unknown	gnl|CDD|234565
NC_019751.1|WP_015197552.1|2225480_2226785_+|threonine-synthase	unknown	unknown	gnl|CDD|236065
NC_019751.1|WP_015197558.1|2232989_2233862_+|lipid-kinase	unknown	unknown	gnl|CDD|183857
NC_019751.1|WP_158333136.1|2242493_2242640_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197553.1|2226866_2227142_+|MoaD/ThiS-family-protein	unknown	unknown	gnl|CDD|340594
NC_019751.1|WP_015197567.1|2248409_2248916_-|DUF29-domain-containing-protein	unknown	unknown	gnl|CDD|366774
NC_019751.1|WP_015197566.1|2246381_2248151_-|glycosyltransferase-family-39-protein	unknown	unknown	gnl|CDD|224720
NC_019751.1|WP_015197564.1|2240797_2241130_-|KaiA-family-protein	unknown	unknown	gnl|CDD|369467
NC_019751.1|WP_015197565.1|2242908_2246325_+|response-regulator	unknown	unknown	gnl|CDD|223715

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015197557.1|2231181_2232912_+|RluA-family-pseudouridine-synthase	gnl|CDD|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	4.01197e-70
NC_019751.1|WP_015197562.1|2238496_2240071_-|circadian-clock-protein-KaiC	gnl|CDD|131703	TIGR02655, Circadian_clock_protein_kinase_KaiC, circadian clock protein KaiC. Members of this family are the circadian clock protein KaiC, part of the kaiABC operon that controls circadian rhythm. It may be universal in Cyanobacteria. Each member has two copies of the KaiC domain (pfam06745), which is also found in other proteins. KaiC performs autophosphorylation and acts as its own transcriptional repressor. [Cellular processes, Other].	0
NC_019751.1|WP_015197569.1|2249406_2250147_+|creatininase-family-protein	gnl|CDD|224320	COG1402, COG1402, Uncharacterized protein, putative amidase [General function prediction only].	3.02496e-84
NC_019751.1|WP_015197560.1|2234771_2235869_-|3-dehydroquinate-synthase	gnl|CDD|234565	PRK00002, aroB, 3-dehydroquinate synthase; Reviewed.	0
NC_019751.1|WP_015197570.1|2250157_2251117_+|LD-carboxypeptidase	gnl|CDD|224534	COG1619, LdcA, Uncharacterized proteins, homologs of microcin C7 resistance protein MccF [Defense mechanisms].	1.82003e-110
NC_019751.1|WP_015197565.1|2242908_2246325_+|response-regulator	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.15673e-46
NC_019751.1|WP_015197556.1|2229281_2230973_-|NADH-quinone-oxidoreductase-subunit-M	gnl|CDD|237137	PRK12561, PRK12561, NAD(P)H-quinone oxidoreductase subunit 4; Provisional.	0
NC_019751.1|WP_015197555.1|2227984_2228791_+|dienelactone-hydrolase-family-protein	gnl|CDD|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	9.52818e-55
NC_019751.1|WP_015197563.1|2240366_2240690_-|circadian-clock-protein-KaiB	gnl|CDD|181770	PRK09301, PRK09301, circadian clock protein KaiB; Provisional.	4.29756e-63
NC_019751.1|WP_015197552.1|2225480_2226785_+|threonine-synthase	gnl|CDD|236065	PRK07591, PRK07591, threonine synthase; Validated.	0
NC_019751.1|WP_015197558.1|2232989_2233862_+|lipid-kinase	gnl|CDD|183857	PRK13057, PRK13057, lipid kinase.	1.11168e-177
NC_019751.1|WP_015197553.1|2226866_2227142_+|MoaD/ThiS-family-protein	gnl|CDD|340594	cd17074, Ubl_CysO_like, ubiquitin-like (Ubl) domain found in Mycobacterium tuberculosis CysO and similar proteins. CysO, also termed 9.5 kDa culture filtrate antigen cfp10A, together with CysM (Cysteine synthase M), forms a protein complex CysM-CysO that represents a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. The replacement of the acetyl group of O-acetylserine by CysO thiocarboxylate to generate a protein-bound cysteine is catalyzed by CysM in a pyridoxal 5?-phosphate (PLP)-dependent manner. The family also includes QbsE that functions as the sulfide donor for the biosynthesis of thioquinolobactin in Pseudomonas fluorescens. A JAMM motif protein QbsD catalyzes removal of the carboxy-terminal dipeptide from QbsE. Both CysO and QbsE are similar to prokaryotic sulfur carrier proteins such as ThiS and MoaD, containing the beta-grasp ubiquitin-like fold.	6.12891e-46
NC_019751.1|WP_015197567.1|2248409_2248916_-|DUF29-domain-containing-protein	gnl|CDD|366774	pfam01724, DUF29, Domain of unknown function DUF29. This family consists of various hypothetical proteins from cyanobacteria, none of which are functionally described. The aligned region is approximately 120-140 amino acids long corresponding to almost the entire length of the proteins in the family. Structure 3fcn is a small protein that has a novel all-alpha fold. The N-terminal helical hairpin is likely to function as a dimerization module. This protein is a member of PFam family PF01724. The function of this protein is unknown. One protein sequence contains a fusion of this protein and a DnaB domain, suggesting a possible role in DNA helicase activity (hypothetical). Dali hits have low Z and high rmsd, suggesting probably only topological similarities (not functional relevance) (details derived from TOPSAN). The family has several highly conserved sequence motifs, including YD/ExD, DxxNVxEEIE, and CPY/F/W, as well as conserved tryptophans.	5.37011e-67
NC_019751.1|WP_015197566.1|2246381_2248151_-|glycosyltransferase-family-39-protein	gnl|CDD|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	4.08176e-59
NC_019751.1|WP_015197564.1|2240797_2241130_-|KaiA-family-protein	gnl|CDD|369467	pfam07688, KaiA, KaiA C-terminal domain. The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. The overall fold of the KaiA C-terminal domain is that of a four-helix bundle, which forms a dimer in the known structure.	5.44195e-42

Protein sequences

>NC_019751.1|WP_144051017.1|2235997_2236093_+|cytochrome-B6
MLGAILFVLFIGAFIGLAIGLLFGLRAVKLI
>NC_019751.1|WP_015197560.1|2234771_2235869_-|3-dehydroquinate-synthase
MASTITVSLPQQSYEIAIAPGSLSLLGGHLAKLNLGKKILVVSNPTVFPLYGESAIASLQEAGFDVFTCILPDGERYKNLEVLQKIYDVCLQNRLERSSTMVALGGGVIGDMTGFAAATWLRGINFVQVPTTLLAMVDSSIGGKTGVNHPQGKNLIGAFYQPQFVLIDPDVLKTLPVREFRAGMAEVIKYGVIWDRDFFAQMEASSHLDAMDNISPELMELILKRSCQAKADVVSQDEKESGIRAILNYGHTIGHAVESLTGYTEVVHGEGVGIGMVAAGKIAAELGMWTQAEVERQDSLIVKAGLPRKLPPGLDISQIVEALQIDKKVKAGKVRFILPTQIGNVTITDEVPADIILRVLAEMGN
>NC_019751.1|WP_015197559.1|2234440_2234623_+|hypothetical-protein
MLDGASVAIHPQAIEPWGIPQVWLKNKEPQPINRLRLKFNQGASTIYLSKAVPDISGKNS
>NC_019751.1|WP_015197558.1|2232989_2233862_+|lipid-kinase
MNERALLLINHHSRQGKQRSDEVVAYLQNLGLELFIESTDEPHHMTEMIHQYKHRVDLVIVGGGDGTLNAAIEGLLETKLPLGVLPLGTANDLARTLNIPNSLPAACNAIASGKIRYIDLGWVNGKHFFNVASLGLSVKITQRLTKQAKRRWGVLAYAATALKVIWESRPFSADIILQGRTISVKTVQIAVGNGRYYGGGMAVVFDANIDDQRLDLYSLEMKHWWQIIPLLPAMRDGKHIHWRNVRALEGQEFEVYTRKPRPINTDGEITTYTPAHFRVIPKAIAVFVPN
>NC_019751.1|WP_015197557.1|2231181_2232912_+|RluA-family-pseudouridine-synthase
MVLHRVTDFVGEGFAVPDLLPGYYYEGVCPQTGVLLRLPRTALVESVARGLMADLAVDEGYAQKGKMFGVLLVELPSGEQRVLKAFSGLLNGCNLVEGWVPPIPGRESVVVDETETLVMLDAIKQELIRLRELPERLEYENLAREWEVTLQQMSVVHSDRKSQRSQERQAFAEDITVLTRLDYESRKDGTERRLLKRKIRGVLEPLELVIKAADARIQELKSQRRQLSRQLQVKMHAAYSVMNFYGMSQSLQKFMPHGLPTGTGDCCAPKLLNYAASNGFKPLAMAEFWWGAGTFTGKVSGEFYGACVERCQPMMGFLLSGLNEGRSQEAEGSHDEQIFSPVKNVRDFSTTPYSLLPTHLQVRKLEIAEISVIYEDEWLMVVNKPAGLLSVPGRYYDTQDSVVSRLQNVLPDGNKIASVHRLDGETSGILLLAKDTQTHRQLSGQFQGRKVKKVYEALLSGLLSSDRGTVELPLWGNPENRPYQQVNWEYGKPSVTNFEVIKREGNYTRINFYPLTGRTHQLRVHAADKAGLNIPILGDSLYGCDDGRRLHLHAKELCFGHPQSGENLCLQVETPF
>NC_019751.1|WP_015197556.1|2229281_2230973_-|NADH-quinone-oxidoreductase-subunit-M
MMADQFPWLTAIILLPLVGAFLIPLLPDKDGKYVRWYALGVGIADFILMCLAFWLNYDPNSTTFQMAESYSWLPQIGLSWSVSVDGLSFPLVLLAGFVTTLAIFSAWQVDRRPKLFYSLMLVLYAAQIGVFVAQDLLLFFIMWEVELIPVYLLICIWGGQKRRYAATKFLIYTAAASIFIIVAAIAMALYGGNDVTFDIVALKLKDYPLGLELFLYAGLLIAFGVKLAVFPLHTWLPDAHGEASSPVSMILAGVLLKMGGYGIIRLNLEMLPNAHIYFAPVLAILGVVNIIYGALNSFAQNNMKRRLAYSSISHMGFVLLGIASFTDLGINGAMLQMISHGLIASVLFFLAGITYDRTHTMMMEEMGGVGQAMPKVFALFTIGAMASLALPGMSGFAGELSVFLGITTSDIYSSTFCTVTIFLAAVGVILTPIYLLNLLRQVFYGNGKSLICDINNTTSTNLTDEEVACFGTDCLLPSQSIYRDASPREIFIAACFIVLIVGIGLYPKAAMGMYDAKTVAINTQVRQSYTQIAQTNPRVYANGFLNPQIIESEMPSVLGTLNQ
>NC_019751.1|WP_015197555.1|2227984_2228791_+|dienelactone-hydrolase-family-protein
MKRRDLLITSAAVASTSLIAKFGTDKTIAAQAVKGKTVTLAEGLEGYYVYPQGKKSAPAVMVFMEAFGLNSYIKEVCDRLARAGYAALAPDFYHGATYNYTDIQNAIAKLKTLNDDTVMSEVGKGLEFLAKRKEVTANKVGVMGFCMGGRYTFLANAVHADKFKGAVAFYGGGIDNPKDQLGRKSLLDQVAGMKAPIMLIYGAEDNLIPPDEHGRIATALSSAKKRYTLTVFPAAGHGFFSDRRDSYVAPAAKEAWQLTMSFFSENLK
>NC_019751.1|WP_015197554.1|2227503_2227977_+|hypothetical-protein
MLQRFAITSGLILTNILIVTPATWAESTEVQIHFSGVVPERTSVRISPTPNSELLSSLKIIKSPQGQRSTTLHFDSTQPSNIIVSPPEFVSGSHPEPRGTVHTSLLKFEQDSSDTSGKNFTTIPAGKVDLQLQTLVKAPQDLPPGIYNYRATLTIVP
>NC_019751.1|WP_015197553.1|2226866_2227142_+|MoaD/ThiS-family-protein
MTIKVLVPTALQKFTNNQATLECSGTNIDEMINSLEDVCPGIKARLCDEAGKPRRFLNLYVNSEDIRFLDGTSTPLKDGDEVSIVPAVAGG
>NC_019751.1|WP_015197552.1|2225480_2226785_+|threonine-synthase
MTQAIAKQAHVNTGNFKALKCKECGAEYEPKALHVCELCFGPLEVKYDYSNLRLSVTRESIQAGPNSIWRYRDFLPVATDNYIDVGTGMTPLVKSNRLARRLGLKNLYIKNDAVNMPTLSFKDRVVSVALSRARELGFTTVSCASTGNLANSTAAIAAYAGLDCCVFIPSDLEAGKVLGSLVYSPTLMAVKGNYDQVNRLCSEVANTHGWGFVNINLRPYYSEGSKTLGFEVAEQLGWKLPDHVVAPLASGSLFTKIYKGFQEFVEVGLVEDKKVRFSGAQAEGCSPIAEAFKEGRDFIKPVKPNTIAKSLAIGNPADGVYAVELAQKTGGNIESVTDAEIIEAIKLLAETEGIFTETAGGTTVAVLKKLVEAGKIDPDETTVVYITGNGLKTQEAVQGYIGEPFTIDAKLDSFESALERSRTLDRLEWQQVLV
>NC_019751.1|WP_015197562.1|2238496_2240071_-|circadian-clock-protein-KaiC
MSDNDLPSQQNTNLPSPKVGGVEKIRTMIEGFDDISHGGLPIGRTTLVSGTSGTGKTLFSLQFLYNGIHEFNEAGVFVTFEESPSDIIKNAYIFGWDLQRLIEEGKLFIVDASPDPEGQDIIGSFDLSALIERLQYAIRKYKATRVSIDSITAVFQQYEAVGVVRREIFRLVARLKQLYVTTIITTERSEEYGPVASFGVEEFVSDNVVIVRNVLEGERRRRTIEILKLRGTTHMKGEYPFTITNDGVNIFPLGAMRLTQRSSNIRVSSGVEALDVMCGGGFFKDSIILATGATGTGKTLLVSKFIQTGCTGSERAILFAYEESRAQLSRNASSWGINFEELEEQGLLKIICTYPESTGLEDHLQIIKSEIAEFKPSRIAIDSLSALARGVGNNAFRQFVIGVTGYAKQEEITGFFTNTSDQFMGSHSITDSHISTITDTIIMLQYVEIRGEMSRAINVFKMRGSWHDKGIREYNITAEGPEIKDSFRNYERIVSGAPTRVAVDEKAELSRIVQGIQEKSDTNS
>NC_019751.1|WP_015197563.1|2240366_2240690_-|circadian-clock-protein-KaiB
MDKVRKTYVLKLYVAGNTANSVRALKTLKNILETEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLSDRERVLIGLDLLYEELSDDNYFEENT
>NC_019751.1|WP_015197564.1|2240797_2241130_-|KaiA-family-protein
MTSAEQQVLLKQIKLDYRQILIIYFAPDKTLQDRIDKLVETLFRANIPVPRIIEIHMELIDEFSIQLKLEGRTNETLLDYRLTLIDLLANLCEAYRRSVSQSSQIQHNLQ
>NC_019751.1|WP_158333136.1|2242493_2242640_+|hypothetical-protein
MELKHQNNVGITTSKLVKHKVGVFPQAGSDGWELPLRGQLDCEHQLVY
>NC_019751.1|WP_015197565.1|2242908_2246325_+|response-regulator
MLHYSLYEFILSLPSCQGTLRLATILEMFEQTQCDRIIVLNEENIPIGLLNSACLLRKLLLLPEVDLQQQLGNLLNGSLNGEFIEPIQVISAKTKFEDFCQILKQEHSDHKNHHDLNWIVVDDADNRLLGVLDSLRILKYISQQTITKQQPQRKKQLSTAKSSPSQRQKAKLPTPALNVPSKVSSSHQSPHQHPLIQLLERLPWPLMLQTTSGEVVTQNPAWWQQLGMLKDPEGIRQEVEMVLSPFSRQQQEYTPDLVPQASQSVGSSTKVAPSSSPQVSRTKRATKSQKVKPVEVNAPGRCFLDNELGTCTCVVEVQSGQERVWQFAKIPLDSPESKAYGIDYETTFTPAEAILHANLWLMLATDVTEKQQLCKELAAKNADLIQLNRLKDEFLACISHELKTPLTSVLGLSRLLVEQQLGELNERQARYAGLIHQSGRHLMTVVNDILDLTRMETGQMELTPATVNIQVVCDRAIAEAKTIHQQSSKAPIGSSSNSPTHQFTLNIQPGLEEIVADELRLRQMLVHLFSNALKFTETGGKIGLKISRWEGWIAFTIWDTGIGIPEHQQHLIFQKFQQLENPLTRQFEGTGLGLVLTRALARLHGGDVSFLSREGKGSQFTLLLPPTPAKNSFTDQQVRRWSAFNDSNISNQNNTVNSSKNAGLFRETSKPSQNNNDVFWDENEDLILHGKVPLSQSVPNSNSSQRLVLVVEAVGRYIEDLTEQLTGLGYRVVIARSGCEAVEKARRLQPKAIFLNPLLPLLSGWDVLTLLKSDSATRGIKVIVTATAAEKEQAFTNRADSFLSLPVQHQMLAPTLEALQSLSEPKKSGKDQRETITTNNPLRILRLVEPDMESNSQPFLCEHRIIEVDDFEQADVLSKVWEFDVILLDAENQTALNFLEKIAKRPRLSGIPLVTCTVETTQAASQIEGLSVFPCLASSENEHISDVGKTEALLSVLQIAAGVCCPPSILVVDLTVLPDLPKAKRGNLRKNVELELFPGLQPLTVSHGCEWFQALIQYLQTAGLKSSMARSWAELLQQIRHRSIDLLLVCLSESTDEKQIHSAITALSKLPFKLPPVLVLDRRVSDEEPLTLSESMQVAISSLTSKDDNPFDSQTQVLPRSTSMEELLNRINLGLKGY
>NC_019751.1|WP_015197566.1|2246381_2248151_-|glycosyltransferase-family-39-protein
MKNRGFEQFFRELDKRPVLAVMLSVLWLAVFGGIGFFLNLGSVGLVDETEPLFAEASRQMLVRGDWITPFFNNQTRFDKPALIYWCQAIAYSILGVNEWAVRLPSAIAAMVVVGLSFYVLQWYQLQRDNLTGISSPTKRWVTAAFCGAVICFTPEMIIWGRTGVSDMLLTGCIASGLFCFFLGYATSPEENRKKTNWYMFFYIFVAGAILTKGPVGIVLPGLIIAAFLLYVGKLREVMGEMHLILGTLTILVLAAPWYILVTWRNGWSFINSFFLYHNVERFTSVVNRHSAPWYFYFLVVLLLFAPYSVYLPIAIARLKFWRRSWWSSQTRSHQLPLFAVFWFLGVFGFFTVSITKLPSYVLPLMPAAAILIALLWAELLPNSSDAPNYFWLRVSGWVNVAFIITLGVVLFYVPQMLGSDPALPNFGEALQKSNLTTIGGVIWLVCGLILAFFVIRRQWVTILGVNLAAFSLFLLIVITPALFLLDEQRQLPLRQLSAIALQNKQPQDELVMVGFKKPSVVFYTGRSVNYIRTTPGGKDYINSKTTNQLASLLLITQSPKIPQMGLQPKDYTSLGKSGVYELVRLGKKQ
>NC_019751.1|WP_015197567.1|2248409_2248916_-|DUF29-domain-containing-protein
MQIPETNPQMANIPMSAPSLYETDFYGWTQQQVDLIRKQQWNQIEWQNVIEEIESLGKQQRQELRNRLSVLVGHLLKWQFQPQCRSRSWLATLRIQRRDTLRLLQDNPSLKSYLDDGLVEAYENARDLAMGETDLPEETFPLECPYDLEDIFSNSFYPGEPSELVNRQ
>NC_019751.1|WP_015197568.1|2249078_2249255_+|hypothetical-protein
MTTNKLPKKKDEKTPIPQHPLAKLAGKFEGEFWEDTILEIQKFRELEKQDINNILDSK
>NC_019751.1|WP_015197569.1|2249406_2250147_+|creatininase-family-protein
MRLHLSTWQEVETYLETSKGIIIPIGSTEQHGPTGLIGTDAICAEAVAYGVGEATHAIVAPTINVGMALHHIAFPGTISLRPSTMIKVISEQITCLAKVGFNKFYFINGHGGNIATLKAAFSETYAELEDLQIANATQVECQVANWFMCGSVYKLAKELYGDEEGSHATPSEVALTQYIYPEAIKKAPLSEEVGKGHNIYGAKNFRQRYPDGRMGSNPALATPEHGKMFYDAAVKELSQGYLEFVG
>NC_019751.1|WP_015197570.1|2250157_2251117_+|LD-carboxypeptidase
MQAKISNCEPQIKSQIMIPPALQPGDLLRVIAPSGALRELDTFSRGVEVWRSRGYTIEVIPQIDDRWGYLAGTDDKRRFHLQTAWEDPECKGILCARGGFGCTRILEDWDWNRLKNPSSTPTLTPKWLIGFSDITALLWSLHQVGISGVHGAVLTTLAAEAEWSQQRLFDWVEGKEIPPLQGNGWGGGIVDGVLLPGNLTVATHLLGTKYQPNFDDVILAIEDVSEAPYRIDRMLTQWRMSGVLAKVRGIAIGRFSQCEPPANIPSFNVMEVLRDRLSDLNIPIVSDLPFGHDGNNAALPVGVMAKLDANQGTLAIQKN

Crispr_ID: NC_019751_11

• CRISPR_ID: NC_019751_11
• CRISPR_location: 2712338-2712432
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_11

Consensus_repeat	Method
TCGTCGCGCAAGCTTCGCACTCT	CRISPRCasFinder

spacers of NC_019751_11

>11.1|2712361|49|NC_019751|CRISPRCasFinder
CCAACAAACCCAGTAAAATAAGCTATCTGTCACCACAAGCGAACGACTT

CRISPR arrays and Neighbor proteins around NC_019751_11

CRISPR arrays

The CRISPR arrays of NC_019751_11

>merge|NC_019751|11|2712338-2712432|CRISPRCasFinder
TCGTCGCGCAAGCTTCGCACTCTCCAACAAACCCAGTAAAATAAGCTATCTGTCACCACAAGCGAACGACTTACGTCGCGCAAGCTTCGCACTCT

>NC_019751|11|11|2712338-2712432|CRISPRCasFinder
TCGTCGCGCAAGCTTCGCACTCT	CCAACAAACCCAGTAAAATAAGCTATCTGTCACCACAAGCGAACGACTT
ACGTCGCGCAAGCTTCGCACTCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_144051111.1|2712853_2714986_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|315987
NC_019751.1|WP_015197922.1|2701903_2703304_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_144051032.1|2711368_2711635_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197937.1|2724440_2725487_-|MoxR-family-ATPase	unknown	unknown	gnl|CDD|223786
NC_019751.1|WP_015197933.1|2715183_2716182_+|IS630-family-transposase	unknown	unknown	gnl|CDD|315923
NC_019751.1|WP_015197923.1|2703533_2705702_+|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173810
NC_019751.1|WP_015197930.1|2711879_2712083_+|HicB-family-protein	unknown	unknown	gnl|CDD|374224
NC_019751.1|WP_083866366.1|2716543_2718955_+|NACHT-domain-containing-protein	unknown	unknown	gnl|CDD|227922
NC_019751.1|WP_015197939.1|2727045_2728014_-|caspase-family-protein	unknown	unknown	gnl|CDD|334197
NC_019751.1|WP_041740433.1|2729405_2730620_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197935.1|2719104_2720304_-|IS4-family-transposase	unknown	unknown	gnl|CDD|376573
NC_019751.1|WP_015197929.1|2710906_2711257_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197942.1|2730634_2731576_+|MoxR-family-ATPase	unknown	unknown	gnl|CDD|223786
NC_019751.1|WP_015197926.1|2707819_2708185_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_144051033.1|2728074_2729019_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_083866307.1|2708573_2711003_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|315987
NC_019751.1|WP_015197931.1|2712079_2712304_+|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl|CDD|377942
NC_019751.1|WP_015197925.1|2706310_2707723_+|hypothetical-protein	unknown	unknown	gnl|CDD|274009
NC_019751.1|WP_015197938.1|2725508_2727032_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197927.1|2708211_2708457_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_144051111.1|2712853_2714986_-|tetratricopeptide-repeat-protein	gnl|CDD|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	1.52452e-18
NC_019751.1|WP_015197937.1|2724440_2725487_-|MoxR-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	9.78105e-19
NC_019751.1|WP_015197923.1|2703533_2705702_+|S8-family-serine-peptidase	gnl|CDD|173810	cd07484, Peptidases_S8_Thermitase_like, Peptidase S8 family domain in Thermitase-like proteins. Thermitase is a non-specific, trypsin-related serine protease with a very high specific activity. It contains a subtilisin like domain. The tertiary structure of thermitase is similar to that of subtilisin BPN'. It contains a Asp/His/Ser catalytic triad. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) clan include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53 the it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	2.2403e-45
NC_019751.1|WP_015197933.1|2715183_2716182_+|IS630-family-transposase	gnl|CDD|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.90419e-29
NC_019751.1|WP_015197930.1|2711879_2712083_+|HicB-family-protein	gnl|CDD|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	6.74219e-13
NC_019751.1|WP_083866366.1|2716543_2718955_+|NACHT-domain-containing-protein	gnl|CDD|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	5.03351e-50
NC_019751.1|WP_015197939.1|2727045_2728014_-|caspase-family-protein	gnl|CDD|334197	pfam00656, Peptidase_C14, Caspase domain.	1.79102e-09
NC_019751.1|WP_015197935.1|2719104_2720304_-|IS4-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	6.46534e-10
NC_019751.1|WP_015197942.1|2730634_2731576_+|MoxR-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.42479e-20
NC_019751.1|WP_083866307.1|2708573_2711003_-|tetratricopeptide-repeat-protein	gnl|CDD|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	3.65636e-13
NC_019751.1|WP_015197931.1|2712079_2712304_+|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl|CDD|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	1.06576e-17
NC_019751.1|WP_015197925.1|2706310_2707723_+|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.54986e-05

Protein sequences

>NC_019751.1|WP_015197931.1|2712079_2712304_+|type-II-toxin-antitoxin-system-HicA-family-toxin
MTRIRRMGADEVERILQSYGFELISQKGSHRKWRNDDRQLQVIVPYHKGRDLPIGTLRNIMIGADIPELEWKTD
>NC_019751.1|WP_015197930.1|2711879_2712083_+|HicB-family-protein
MKWRVVLEPDPETGEWAVWCPELPGCTSAGDTEEEALENIREAIQLYLETDSIKLAPGAIFREVMVG
>NC_019751.1|WP_144051032.1|2711368_2711635_+|hypothetical-protein
MRSHYVVQARTSFSNKRSHSKPKHQKPSFSPTSERLTSRKLRITTQTTKNRHSHQQTINLWFLSAIALSNQPSKPHFTPNSKTLSVIA
>NC_019751.1|WP_015197929.1|2710906_2711257_-|hypothetical-protein
MPVSEDLFVIVERIINHHESAEDLETLRRLIGTNSSQESLQIGKYGVNVGQGQDIHIGDKIYQGTDAETIREIIAPLIRELQLRESVPSQKAANAVKYSNIYPIQVSVILLDAAKN
>NC_019751.1|WP_083866307.1|2708573_2711003_-|tetratricopeptide-repeat-protein
MSTESKSCKCSQIFKYIPHTGVSHFVGRSKELTKIHEKLHQQNAVVISAVAGMGGVGKTELVIKYALEHEADYPGGICWLSARDANLAAGIIQFVQLHMGLKVPQKDFHENPLTLNQQVGWCWQNWQPLLGLVLVVFDDVTNLENLSELLPTNNRFRVLMTTRLRNLNPKIEEIPLDVLSPNESLEFLINLVGKKKVNKELATAKELSQWLGYLPLGIELVGRHLVKKPPHWTLAQILEQLQQQRIHYRATIPQEKVLSPVQTAVLAAFELSWVELNPTTQKIAVLLSLFAGDIFVWKWVESTAKLLNWHQADVELAIEQLYQRHLVQCVEEKNTCYYKIHPLIREFLQIKSIEISENSELKQAFSSTFVEIARSIPYPLTLNIINSVKNAIPHLTEVAENLIDAVGNENLYWTFTGLARFYGEQGLYGLAETWYQRCVSAIKSRLGEKHPDFAGSLNNLARIYISQGKYETAESLCLEALELRKQLLGENHPYFATSLSSLAELYKSQGKYEAAEPLFIQVLDLLKKQNHPCFAASLSSLAGLYKSQGKYELAEILYLKVLDLEKHQWDRNDRNVVASLDSLAELYRSQERYTEAEPIYIESLELGRRLLGEQHPINAIVLNNLALLKYDQGYYEEAEKFALQSLELDKLLLGEEHPDFATDIHNLALIYRAQNRYREAEELFLKSLEIKTNTLVKGHPLIADTIYALGFMYRLQERYIEAEPLCLRALELDKYIWGENHLNVVRSLDNLAELYCQLQRYEEAEFLYQQALGIIDRILEPNHPKTIAIREKLESLRTQQQENQNRHQN
>NC_019751.1|WP_015197927.1|2708211_2708457_-|hypothetical-protein
MTLIKKSEQQLLLKIKKIEDEEQNIQPDAKDISEVREEQTQVNIESNYIPARDNPIVQSIGNSGWQISDIWRDIRVDNFSD
>NC_019751.1|WP_015197926.1|2707819_2708185_+|hypothetical-protein
MQCREKEIHIKKIPRWFAKFILRSQYNPNNQQIFFTLLEPMTPQEWCLIWIPVIHPGIELPCDGERNPTGYMKACLTTLSTLTGYHERTVEGWFYGKPYHYSVEILLRCFHLIFTLQQYLN
>NC_019751.1|WP_015197925.1|2706310_2707723_+|hypothetical-protein
MNATAPFSLAYSFDYDRFTKPDLQAKAKSTLGNFFGFVRQTFDGLIEIGRSLQDFYFDCLAFCPNGKKVFSEWLASPDFGASRYIASSAMDIYAWFDKLPVRSQKLIRQNVQNWSVSALRQLTKVSHDLVKELVLEGKKTAAQVKHEGGSERAREKEEKQASSEEISRTPSVPTPELARGMRIVVKEENTGWNGHSGIIMSKREDDFWVLLDHTVSQGMEIKHLLKTHQIQLEAQQSVTKPASKELFTDAQVEQKITDALAQREREKAESEQGRFVEIRDAALQAAKREIQAAQEYANALEQAKHKLIEQLASKDLEVRSLHVLQTRNQQLEQRVAELEKALENSSANNWGNTFNNQAAKAVNSELEKTIQPLMSEVERLQNLVRSQQQELAQIQTSDTPEGSGYRQRSASDAVLAEFGEIGERFGWSGWSRRGYRAASGMLSTGISAIAAFIADLKQSSPSYQQQEITF
>NC_019751.1|WP_015197923.1|2703533_2705702_+|S8-family-serine-peptidase
MKRLLSSLVLAGCFLTSTSLPLIPHQYRELAQAQTADELFYTFYGQKIPLNLKRDRVAVSFKPTTNSRSSRSTQPLYLQLQQDLRRGGGNSRSVSSGNGFDIDVKPLGDNIALVNLPTGSRSSLNSIQQRIQNQSYVKETLPILTRKSGEASKEKESEQVIVLPNEIAIAFDRDMSESQRQMVLLRHNLEVVRPLRFSKNRYLVRSKSVSGTEILNLANQLAQVTGVQSATPNFIQATSYQQSQLLANLANLPETPNAAQRLEQQLAQLPQPKDTPVSAKLLPLQWHLNSTPKRGQLLARTDVRATEAWKHSNGGRGTVVAVIDSLIQWDHPDLVKNIYKSGNHPDKLPGEEYGWDFSSSGQGDADTRLSSQELSQIQAEWQNTFKLPSDQLLKKYQQFADVFKKRNPKASPGEIAHQIRNLIRNQISSEFHGTWSAGVIAANSPDKAGVLGVAPNTQILPVRVFALGGAINSASLGEAIGYAASRNVDVINMSLGGLLPDEGLTEQIFDVLDNNRNLVIIASAGNENLDGVAFPAGIPGVLSVGATNMTGNRTFYSSYGGGLDLVAPGGEIQNGMSGGILTTGGTWLDGFWQGISVPDNSWGVALDPVGKYVQVQGTSFSAPIVSGVVALMKGEDPKRRLSREEMVSILKKTATYDGLNLSSSDVNRYRLQKEVGFGTVIDAPISRPSGIFAKAKPVSAQEYFFGKGLVNADAAVESVRKR
>NC_019751.1|WP_015197922.1|2701903_2703304_-|hypothetical-protein
MGNASRYWKLVRIDGGGNRKILEIPTARSFFTQLFGELTDDAPDGDIQRQLMDLYRDSSGESTLLAERCLLCFISGILEQGCLKLTRRFGEKYNFHCNELLPFVLEDDGKLLPAINYQCFSRQILQSFDATQGSLTTWASIKVKQHPELNHFLLERGVYLISNWAILNDTQPQQLQRILKDFHTLGELEIQEAQYLLQGYHTIYRVQRLENIRNKIRSKCIEPTYQQLEDIAIYIKNQTGRLFDNETVRVKLTKLANQLREYRIYVRGGSLPIDSLDASFTDKSNSLLDNVSAPASENSEISDEQSEFLDFYRHQIQVSLQSALTKVTESRVKKLKKKGDKARIFLTALELSQCQKLAMNEIAEQLGMRAQYTVTKLLKLKELRTDVQQEMLIILKDSVKEQAKKYAGVEALNKLDEQLTIFLSSEISKIIENAESQSRTAKNYLKTDIFAQRLCEYLDMRKQVNN
>NC_019751.1|WP_144051111.1|2712853_2714986_-|tetratricopeptide-repeat-protein
MIERILSHQHTEADLVLLRQAISASSSQGTLQIGKYNVNIGEGKDVHIGDKVYHGADAEAIREIIKEILPSQKAATAVKYIPYTGVRNFVGRSDELVKIHEKLYQQQNTVAISAVSGMGGIGKTELAVKYAREHENYYPGGICWFSVRDRNLAAEIIQFTQLYLNLEVPQKDARENPLDIHQQVAWCWQNWQPPEGLVLVVLDDVTDLKDIKEFLPKTNNRFRILITTRQRRLDINYAEISLDVLSPEEALSLLKGILGENDRRVDREIEIANSLCKWLGYLPLGLELIGRYLVEDPDLSITEMLQALREERLKNEAISPSFEDLENTEITAKLGVRDAFNLTWEKLDPKTKRVGELLSLFSPDEIAWEYVESVSKSLSWEKKEVNEAKKQLYKRHLIERLESVEANYKIHPLIREFLRDKLGELEEVNEFKQAFTSTFMEIAQTIPQSPTLEFIDSVKTAIPHLTEVAENLLDAVSDENLIWAFTGLAWYYNGQGLYALAAPWYQGCVSAVRLRLGENHPHVAQSLNNLAYLYSSQGRCEAAEPLYIQALELYKQLLGENHPDVATSLNNLAGLYRSQGRYEAAEPLYIQALELRKQLLGENHPDVAQSLNNLALLYNSQGRYEAAEPLYIQALELYKQLLGENHPSYATSLNNLALLYCSQGRYEAAEPLYIQALEIAERVLDVNHPNTLTCRGNLEYLRTQQRESGG
>NC_019751.1|WP_015197933.1|2715183_2716182_+|IS630-family-transposase
MFFIKEINPLSLKLLERIYRQSRHHQVRQRAHFLILASQGVKVDELMRIFSVSYKTIYNWQNRWESEGMVGLYNKPGRGSKKIFERSQEEEIREWARLEPRQIKRVLQKVKEEWDVVVSAETIKRILKRLSMSWHRMRRDVFGKPDPLEYKDKKEKLSELKRLEDEGKINLYYLDEAGFCLIPTVPYGWQNIGEYLKIKSRRSPRLNVLGIMSRKNHLETYVSSQTINSDVVVACIDTFFPTVNKPTYIVADRASIHTSDIVLDKIEEWKERGITIFELPSYSPDLNLIEILWRFIKYQWIEIDAYSSWQTFVTSLEKILREFGQNYVINFD
>NC_019751.1|WP_083866366.1|2716543_2718955_+|NACHT-domain-containing-protein
MLSEQQRLTTNPLTSGEGISHRTTQVYVPLGLVERKKQTRRKEDVSPEQGSELYRETEITQTFEYQQFLQQVLKQRQSPKSQGKRIAIIGEPGAGKTTLLQQIASWVSGEIPDAIVIWISLADLQGQELEVYLFDKWLQAVARKVGQAEASTQVKDDFVAQFNRGLVWLLLDGVDEMQATQGNPLGECDRQLRAGSLLQQARIVLSCRLNLWDGGSNSLDSFDNYRTLEFSYPQQVEQFIGNWFASLPSAETQIGERLCAALAESGKERIRDLAKNPLRLTLLCFNWYLGEGKLPETKAGLYEQFVADFYEWKKGQFATTGEQRKRLNTALGELAREAIEKEATRFRLRQDFVCEYLGEPDDADSLFGLALRLGWLNKVGVDGDNPRKGVYGFFHPTFQEYFAALAIDDWHYFLNHIPDNPSHPNASYRIFEQQCREIFFLWIGFPQNNFLPAIEALMSFEDACKSWNISVKSFYEHQAYMIVIYCLMEIGIRKQYKEIFKEIVNYILNLFGEQKQHNYWLFLSDAVFPILDDLYTKNILQELFNLVNDQKTIGKTKQIILICREKQLREQNKIILKQNNVLDIITEIDKLIIKSNPGESITYRLSQLIELISKNNVLLIQALIKILNYEHPRHIKLKTIIALGLASHENLDAIAALNKEIESSPDLIYLFYTTKTLVAINPRNREAILLLRELMPTLHIYMQIEACELLMNDEEIAYDLFIKLIELIQSDPDDEVYYRACQTLKANINTDILYYSLLISKLRDCLTNKIYEDEFFRFRDCYELLWCYSQELSYKAFYEAWFQ
>NC_019751.1|WP_015197935.1|2719104_2720304_-|IS4-family-transposase
MLPQSYQKIFQKHLSEQQYLTLELLLLLIQAYRQVKLSTLANLFPQPITYESRKRNLQRFLVVGSLCVKLLWFPLVKYWIRQSQTGHNLNREQRRYYKQQKHKKYGYWMIGIDRTQWKDRNLFMVTLVWGTHALPLYWETLPHVGNSNFQAQKRLLSIALSLFKNYPVLVIGDREFHSPKLAQWLDNRGVYFALRQKKDLHFQEESDEEYQILKDKGFKPGMSKFYIGVKCNKGDGLGLFNLAVYWKRKYRNQGSQQPWYILTNLPTFKQTLEVYRCRWGIEQFFRDCKTGGYNLEDTKVNETRFLALVLLIVIAYSLGTMYGQRMQILGIETYAGRIKQHKDKYPRQSDFSFAIYGQRWIYAMELWADLALGLIALKPHKRLHFQRGFHALSLMKQAL
>NC_019751.1|WP_015197937.1|2724440_2725487_-|MoxR-family-ATPase
MTDWKIFQGNSEPHDNINQLPPPPSWRKFLDVDDQIVAQTEQRWQKFCEESEHNIKDEERGKSFRIHTDKNNDRNTVINMVNAALYLRRPLLVTGKPGTGKTSLAYAVAYELKLGAVLPWYITARSTLQEGLYRYDAIARLQDVQMGDKSKDIGRYIQLGPLGTALLPSRRPRVLLIDEIDKSDINLPNDLLNLFEEGEFEIPELARISKEVNQVEVRTYDGIDVPIKAGRVRCQNFPFILLTNNGERDFPPAFLRRCLRLNMPYEPDADALKEIVKAHLGSDTITKDEEKINQLIAKFRTLRESGDIATDQLLNAIYMVTREFKPEQAEEQDLIEVLLKYLTSAEDR
>NC_019751.1|WP_015197938.1|2725508_2727032_-|hypothetical-protein
MNINEIEINAIFDKITDNQHTAADLLVLRKTLNAGDKSTLKQLGKYITNIEEGKDIHIGDRTYNQWDKDAMEALVKAIQATSGIHQNTQDGDVAARDIDKRNVYKNCTFIQLLSSDSNFSNLSQESLNDLDFSRIPQESIQQAYQEALPPDAGVWGLEENNITQILQKLEQFRRLFDFFNRLSQDKNVPQEIRNKLNVVAEELALKKYPDENKNKLPADFVSNKEGQLQSYLIATLERCSDNEDFLLNAWLIIDDSIPGNNLSKFTSLLAQDEQQQGTLCKFNDIPKQLNKFLKTSLKYLRGKQYQLIIEIFLPSDLIGTEVDRWKISDPIVEEITLGIKYPIRLRSLERLDIDYLDSYLSDWYKYWDKVKTVLHNEPIQELFAHLQEMETFNWKSLRNNLQEKIGLKLTCAPPKAKTKELFKAILTATTPIAIWTRYDIPNFDHVSAIDEILTFKPLCHLCESVRQTREKADAQTEEHLGFHLALLWEDPYRLTPNVMLELKTPGQ
>NC_019751.1|WP_015197939.1|2727045_2728014_-|caspase-family-protein
MGDNLTKFSNGYALLIGVGESKYAPLSLPVTVKDTQGIYAALIDPELCAYPDDQDHIRVLNNQEATKAAIVDGLSWLKEKAESDKNATIFIYYSGHGWVDKNTQKYYLLQHDIKPTKLASSALAAEIFTDALREIQAERLLVVIDSCHAAGMATSKDADLELEEEFDDFIRVAPSKGFIDELKQGKGRVVFTSSKGEQKSYLKDDSCSIYTYHFLEALQGAGNKSGDTEVRVSNIMNHLGKAVPESARQYNVEQVPHFDLDAGDFAIAQLRGGKGLPSKGWDEVRSEATQKINKIADVINQHGKFITNINEAHGIHIGDNYS
>NC_019751.1|WP_144051033.1|2728074_2729019_-|hypothetical-protein
MFSNRRANIVSSVFADIKVIGECEEPEWIAAKLQQMQDPDFRGDVLENMNETPGGKGILEFLNLVQDQPWMYASHKFGYIAPRKPGSMKPQIIQHPSAIAADTSLKNSSINIRLDRLHIAKYPGGGTHNVMVTFAARNQVADTQETVSFSQTYRVQEGQSAGIAGYPVFIGLNVGSQGVAFECSTVNVKNNEDQAILSTLESSPFQSGLKLLTTAQPAIAPFTEITVGVVKMLAQRNENVAVQKFYLGLDFENMAMGCRLAEGNYIAIQVPDEIAIDWKQWIYKPDLGVIVHKSDDYETLPYNYVIFRVSRYEN
>NC_019751.1|WP_041740433.1|2729405_2730620_+|hypothetical-protein
MNQGIVKTETQQDILKDLMVARDLTTGDVTQQNIQNQIILLVNNLDDGTINKAFSATVPDDWYIWRNTYKTVNEALKQLEEIPYQNPSDTPLLKFASLLTQDNNIPESIREKLKQLLTNQAFKTNKKSPSTQSLHSYLLIQLRPQVTNELFVKAWFIPDDTIQDPWERFKPLTVDEQQPEIPFVPEELPQLLGNLLQQCFDEYLQGEATELTIEIFLPRDRLCDEVEKWSYQDSEGLDITIGEEHRVVVRSYDRLKTLRKQQGSYWKKNWENLQLIWQDIPCIEQITTISQACFDPNHLRKSLIEKIILKVCCNLSNSDRDGLLKAIHSAGTPIVIWSRCEVTNLKNPHHFDALLEQPLRELSARIKEQRLAADHEMHLGNHLVLLWDDPNRIPPNSALEFSAS
>NC_019751.1|WP_015197942.1|2730634_2731576_+|MoxR-family-ATPase
MSDWLIFQGTEKPHDGIKNLPSAPKWREFGEEKEKQRGETFQVRRNEIELVNAALYLRRPLLVTGKPGTGKTSLAYKVAQELQLGSVLQWAITTRSTLQQGLYRYDAIARLQDAQGKDNTRDIGKYIQLGPLGTALLPSPHPRVLLIDEIDKSDIDLPNDLLNIFEEGEFEIPELARLPEEYETVKVRGYDGGVANITKGRVRCTQFPFVLLTSNGEREFPPAFLRRCLRLTMENPDAKALEKIVRSHLGDGVMSEAEALIDQFIQLRDKPDAGDLATDQLLNAIYLVTRERSPVGNDKERLLKALMAYLTTT

Crispr_ID: NC_019751_12

• CRISPR_ID: NC_019751_12
• CRISPR_location: 2712512-2712723
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_019751_12

Consensus_repeat	Method
CCAACCCAAAACACCAAAAACCGTCATTCTCAGCAACAAGCGATCGCA	PILER-CR

spacers of NC_019751_12

>12.1|2712560|45|NC_019751|PILER-CR
TTACGTCGCGCAAGCTAGAACTTCGTTCAGCTACGCTAACGCACT
>12.2|2712653|28|NC_019751|PILER-CR
ACGACTTTCGTCGCGCAAGCTTCGCATC

CRISPR arrays and Neighbor proteins around NC_019751_12

CRISPR arrays

The CRISPR arrays of NC_019751_12

>merge|NC_019751|12|2712512-2712723|PILER-CR
CCATCCCAAAGTAGCTAAAATCGTCATTCTCAGCAACAAGCGATCGCATTACGTCGCGCAAGCTAGAACTTCGTTCAGCTACGCTAACGCACTCCAATTCAAAACACCAAAAACCGTCATTCTCAGTAATAAGCGAACGACTTTCGTCGCGCAAGCTTCGCATCTCAACCCAAAACACCAAAAACCGTCATTCTCAGCAACAAGCGATCGCA

>NC_019751|12|7|2712512-2712723|PILER-CR
CCATCCCAAAGTAGCTAAAATCGTCATTCTCAGCAACAAGCGATCGCA	TTACGTCGCGCAAGCTAGAACTTCGTTCAGCTACGCTAACGCACT
CCAATTCAAAACACCAAAAACCGTCATTCTCAGTAATAAGCGAACGAC	TTTCGTCGCGCAAGCTTCGCATCTCAAC
CCAAAACACCAAAAACCGTCATTCTCAGCAACAAGCGATCGCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_144051111.1|2712853_2714986_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|315987
NC_019751.1|WP_015197922.1|2701903_2703304_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_144051032.1|2711368_2711635_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197937.1|2724440_2725487_-|MoxR-family-ATPase	unknown	unknown	gnl|CDD|223786
NC_019751.1|WP_015197933.1|2715183_2716182_+|IS630-family-transposase	unknown	unknown	gnl|CDD|315923
NC_019751.1|WP_015197923.1|2703533_2705702_+|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173810
NC_019751.1|WP_015197930.1|2711879_2712083_+|HicB-family-protein	unknown	unknown	gnl|CDD|374224
NC_019751.1|WP_083866366.1|2716543_2718955_+|NACHT-domain-containing-protein	unknown	unknown	gnl|CDD|227922
NC_019751.1|WP_015197939.1|2727045_2728014_-|caspase-family-protein	unknown	unknown	gnl|CDD|334197
NC_019751.1|WP_041740433.1|2729405_2730620_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197935.1|2719104_2720304_-|IS4-family-transposase	unknown	unknown	gnl|CDD|376573
NC_019751.1|WP_015197929.1|2710906_2711257_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197942.1|2730634_2731576_+|MoxR-family-ATPase	unknown	unknown	gnl|CDD|223786
NC_019751.1|WP_015197926.1|2707819_2708185_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_144051033.1|2728074_2729019_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_083866307.1|2708573_2711003_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|315987
NC_019751.1|WP_015197931.1|2712079_2712304_+|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl|CDD|377942
NC_019751.1|WP_015197925.1|2706310_2707723_+|hypothetical-protein	unknown	unknown	gnl|CDD|274009
NC_019751.1|WP_015197938.1|2725508_2727032_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015197927.1|2708211_2708457_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_144051111.1|2712853_2714986_-|tetratricopeptide-repeat-protein	gnl|CDD|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	1.52452e-18
NC_019751.1|WP_015197937.1|2724440_2725487_-|MoxR-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	9.78105e-19
NC_019751.1|WP_015197923.1|2703533_2705702_+|S8-family-serine-peptidase	gnl|CDD|173810	cd07484, Peptidases_S8_Thermitase_like, Peptidase S8 family domain in Thermitase-like proteins. Thermitase is a non-specific, trypsin-related serine protease with a very high specific activity. It contains a subtilisin like domain. The tertiary structure of thermitase is similar to that of subtilisin BPN'. It contains a Asp/His/Ser catalytic triad. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) clan include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53 the it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	2.2403e-45
NC_019751.1|WP_015197933.1|2715183_2716182_+|IS630-family-transposase	gnl|CDD|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.90419e-29
NC_019751.1|WP_015197930.1|2711879_2712083_+|HicB-family-protein	gnl|CDD|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	6.74219e-13
NC_019751.1|WP_083866366.1|2716543_2718955_+|NACHT-domain-containing-protein	gnl|CDD|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	5.03351e-50
NC_019751.1|WP_015197939.1|2727045_2728014_-|caspase-family-protein	gnl|CDD|334197	pfam00656, Peptidase_C14, Caspase domain.	1.79102e-09
NC_019751.1|WP_015197935.1|2719104_2720304_-|IS4-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	6.46534e-10
NC_019751.1|WP_015197942.1|2730634_2731576_+|MoxR-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.42479e-20
NC_019751.1|WP_083866307.1|2708573_2711003_-|tetratricopeptide-repeat-protein	gnl|CDD|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	3.65636e-13
NC_019751.1|WP_015197931.1|2712079_2712304_+|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl|CDD|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	1.06576e-17
NC_019751.1|WP_015197925.1|2706310_2707723_+|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.54986e-05

Protein sequences

>NC_019751.1|WP_015197931.1|2712079_2712304_+|type-II-toxin-antitoxin-system-HicA-family-toxin
MTRIRRMGADEVERILQSYGFELISQKGSHRKWRNDDRQLQVIVPYHKGRDLPIGTLRNIMIGADIPELEWKTD
>NC_019751.1|WP_015197930.1|2711879_2712083_+|HicB-family-protein
MKWRVVLEPDPETGEWAVWCPELPGCTSAGDTEEEALENIREAIQLYLETDSIKLAPGAIFREVMVG
>NC_019751.1|WP_144051032.1|2711368_2711635_+|hypothetical-protein
MRSHYVVQARTSFSNKRSHSKPKHQKPSFSPTSERLTSRKLRITTQTTKNRHSHQQTINLWFLSAIALSNQPSKPHFTPNSKTLSVIA
>NC_019751.1|WP_015197929.1|2710906_2711257_-|hypothetical-protein
MPVSEDLFVIVERIINHHESAEDLETLRRLIGTNSSQESLQIGKYGVNVGQGQDIHIGDKIYQGTDAETIREIIAPLIRELQLRESVPSQKAANAVKYSNIYPIQVSVILLDAAKN
>NC_019751.1|WP_083866307.1|2708573_2711003_-|tetratricopeptide-repeat-protein
MSTESKSCKCSQIFKYIPHTGVSHFVGRSKELTKIHEKLHQQNAVVISAVAGMGGVGKTELVIKYALEHEADYPGGICWLSARDANLAAGIIQFVQLHMGLKVPQKDFHENPLTLNQQVGWCWQNWQPLLGLVLVVFDDVTNLENLSELLPTNNRFRVLMTTRLRNLNPKIEEIPLDVLSPNESLEFLINLVGKKKVNKELATAKELSQWLGYLPLGIELVGRHLVKKPPHWTLAQILEQLQQQRIHYRATIPQEKVLSPVQTAVLAAFELSWVELNPTTQKIAVLLSLFAGDIFVWKWVESTAKLLNWHQADVELAIEQLYQRHLVQCVEEKNTCYYKIHPLIREFLQIKSIEISENSELKQAFSSTFVEIARSIPYPLTLNIINSVKNAIPHLTEVAENLIDAVGNENLYWTFTGLARFYGEQGLYGLAETWYQRCVSAIKSRLGEKHPDFAGSLNNLARIYISQGKYETAESLCLEALELRKQLLGENHPYFATSLSSLAELYKSQGKYEAAEPLFIQVLDLLKKQNHPCFAASLSSLAGLYKSQGKYELAEILYLKVLDLEKHQWDRNDRNVVASLDSLAELYRSQERYTEAEPIYIESLELGRRLLGEQHPINAIVLNNLALLKYDQGYYEEAEKFALQSLELDKLLLGEEHPDFATDIHNLALIYRAQNRYREAEELFLKSLEIKTNTLVKGHPLIADTIYALGFMYRLQERYIEAEPLCLRALELDKYIWGENHLNVVRSLDNLAELYCQLQRYEEAEFLYQQALGIIDRILEPNHPKTIAIREKLESLRTQQQENQNRHQN
>NC_019751.1|WP_015197927.1|2708211_2708457_-|hypothetical-protein
MTLIKKSEQQLLLKIKKIEDEEQNIQPDAKDISEVREEQTQVNIESNYIPARDNPIVQSIGNSGWQISDIWRDIRVDNFSD
>NC_019751.1|WP_015197926.1|2707819_2708185_+|hypothetical-protein
MQCREKEIHIKKIPRWFAKFILRSQYNPNNQQIFFTLLEPMTPQEWCLIWIPVIHPGIELPCDGERNPTGYMKACLTTLSTLTGYHERTVEGWFYGKPYHYSVEILLRCFHLIFTLQQYLN
>NC_019751.1|WP_015197925.1|2706310_2707723_+|hypothetical-protein
MNATAPFSLAYSFDYDRFTKPDLQAKAKSTLGNFFGFVRQTFDGLIEIGRSLQDFYFDCLAFCPNGKKVFSEWLASPDFGASRYIASSAMDIYAWFDKLPVRSQKLIRQNVQNWSVSALRQLTKVSHDLVKELVLEGKKTAAQVKHEGGSERAREKEEKQASSEEISRTPSVPTPELARGMRIVVKEENTGWNGHSGIIMSKREDDFWVLLDHTVSQGMEIKHLLKTHQIQLEAQQSVTKPASKELFTDAQVEQKITDALAQREREKAESEQGRFVEIRDAALQAAKREIQAAQEYANALEQAKHKLIEQLASKDLEVRSLHVLQTRNQQLEQRVAELEKALENSSANNWGNTFNNQAAKAVNSELEKTIQPLMSEVERLQNLVRSQQQELAQIQTSDTPEGSGYRQRSASDAVLAEFGEIGERFGWSGWSRRGYRAASGMLSTGISAIAAFIADLKQSSPSYQQQEITF
>NC_019751.1|WP_015197923.1|2703533_2705702_+|S8-family-serine-peptidase
MKRLLSSLVLAGCFLTSTSLPLIPHQYRELAQAQTADELFYTFYGQKIPLNLKRDRVAVSFKPTTNSRSSRSTQPLYLQLQQDLRRGGGNSRSVSSGNGFDIDVKPLGDNIALVNLPTGSRSSLNSIQQRIQNQSYVKETLPILTRKSGEASKEKESEQVIVLPNEIAIAFDRDMSESQRQMVLLRHNLEVVRPLRFSKNRYLVRSKSVSGTEILNLANQLAQVTGVQSATPNFIQATSYQQSQLLANLANLPETPNAAQRLEQQLAQLPQPKDTPVSAKLLPLQWHLNSTPKRGQLLARTDVRATEAWKHSNGGRGTVVAVIDSLIQWDHPDLVKNIYKSGNHPDKLPGEEYGWDFSSSGQGDADTRLSSQELSQIQAEWQNTFKLPSDQLLKKYQQFADVFKKRNPKASPGEIAHQIRNLIRNQISSEFHGTWSAGVIAANSPDKAGVLGVAPNTQILPVRVFALGGAINSASLGEAIGYAASRNVDVINMSLGGLLPDEGLTEQIFDVLDNNRNLVIIASAGNENLDGVAFPAGIPGVLSVGATNMTGNRTFYSSYGGGLDLVAPGGEIQNGMSGGILTTGGTWLDGFWQGISVPDNSWGVALDPVGKYVQVQGTSFSAPIVSGVVALMKGEDPKRRLSREEMVSILKKTATYDGLNLSSSDVNRYRLQKEVGFGTVIDAPISRPSGIFAKAKPVSAQEYFFGKGLVNADAAVESVRKR
>NC_019751.1|WP_015197922.1|2701903_2703304_-|hypothetical-protein
MGNASRYWKLVRIDGGGNRKILEIPTARSFFTQLFGELTDDAPDGDIQRQLMDLYRDSSGESTLLAERCLLCFISGILEQGCLKLTRRFGEKYNFHCNELLPFVLEDDGKLLPAINYQCFSRQILQSFDATQGSLTTWASIKVKQHPELNHFLLERGVYLISNWAILNDTQPQQLQRILKDFHTLGELEIQEAQYLLQGYHTIYRVQRLENIRNKIRSKCIEPTYQQLEDIAIYIKNQTGRLFDNETVRVKLTKLANQLREYRIYVRGGSLPIDSLDASFTDKSNSLLDNVSAPASENSEISDEQSEFLDFYRHQIQVSLQSALTKVTESRVKKLKKKGDKARIFLTALELSQCQKLAMNEIAEQLGMRAQYTVTKLLKLKELRTDVQQEMLIILKDSVKEQAKKYAGVEALNKLDEQLTIFLSSEISKIIENAESQSRTAKNYLKTDIFAQRLCEYLDMRKQVNN
>NC_019751.1|WP_144051111.1|2712853_2714986_-|tetratricopeptide-repeat-protein
MIERILSHQHTEADLVLLRQAISASSSQGTLQIGKYNVNIGEGKDVHIGDKVYHGADAEAIREIIKEILPSQKAATAVKYIPYTGVRNFVGRSDELVKIHEKLYQQQNTVAISAVSGMGGIGKTELAVKYAREHENYYPGGICWFSVRDRNLAAEIIQFTQLYLNLEVPQKDARENPLDIHQQVAWCWQNWQPPEGLVLVVLDDVTDLKDIKEFLPKTNNRFRILITTRQRRLDINYAEISLDVLSPEEALSLLKGILGENDRRVDREIEIANSLCKWLGYLPLGLELIGRYLVEDPDLSITEMLQALREERLKNEAISPSFEDLENTEITAKLGVRDAFNLTWEKLDPKTKRVGELLSLFSPDEIAWEYVESVSKSLSWEKKEVNEAKKQLYKRHLIERLESVEANYKIHPLIREFLRDKLGELEEVNEFKQAFTSTFMEIAQTIPQSPTLEFIDSVKTAIPHLTEVAENLLDAVSDENLIWAFTGLAWYYNGQGLYALAAPWYQGCVSAVRLRLGENHPHVAQSLNNLAYLYSSQGRCEAAEPLYIQALELYKQLLGENHPDVATSLNNLAGLYRSQGRYEAAEPLYIQALELRKQLLGENHPDVAQSLNNLALLYNSQGRYEAAEPLYIQALELYKQLLGENHPSYATSLNNLALLYCSQGRYEAAEPLYIQALEIAERVLDVNHPNTLTCRGNLEYLRTQQRESGG
>NC_019751.1|WP_015197933.1|2715183_2716182_+|IS630-family-transposase
MFFIKEINPLSLKLLERIYRQSRHHQVRQRAHFLILASQGVKVDELMRIFSVSYKTIYNWQNRWESEGMVGLYNKPGRGSKKIFERSQEEEIREWARLEPRQIKRVLQKVKEEWDVVVSAETIKRILKRLSMSWHRMRRDVFGKPDPLEYKDKKEKLSELKRLEDEGKINLYYLDEAGFCLIPTVPYGWQNIGEYLKIKSRRSPRLNVLGIMSRKNHLETYVSSQTINSDVVVACIDTFFPTVNKPTYIVADRASIHTSDIVLDKIEEWKERGITIFELPSYSPDLNLIEILWRFIKYQWIEIDAYSSWQTFVTSLEKILREFGQNYVINFD
>NC_019751.1|WP_083866366.1|2716543_2718955_+|NACHT-domain-containing-protein
MLSEQQRLTTNPLTSGEGISHRTTQVYVPLGLVERKKQTRRKEDVSPEQGSELYRETEITQTFEYQQFLQQVLKQRQSPKSQGKRIAIIGEPGAGKTTLLQQIASWVSGEIPDAIVIWISLADLQGQELEVYLFDKWLQAVARKVGQAEASTQVKDDFVAQFNRGLVWLLLDGVDEMQATQGNPLGECDRQLRAGSLLQQARIVLSCRLNLWDGGSNSLDSFDNYRTLEFSYPQQVEQFIGNWFASLPSAETQIGERLCAALAESGKERIRDLAKNPLRLTLLCFNWYLGEGKLPETKAGLYEQFVADFYEWKKGQFATTGEQRKRLNTALGELAREAIEKEATRFRLRQDFVCEYLGEPDDADSLFGLALRLGWLNKVGVDGDNPRKGVYGFFHPTFQEYFAALAIDDWHYFLNHIPDNPSHPNASYRIFEQQCREIFFLWIGFPQNNFLPAIEALMSFEDACKSWNISVKSFYEHQAYMIVIYCLMEIGIRKQYKEIFKEIVNYILNLFGEQKQHNYWLFLSDAVFPILDDLYTKNILQELFNLVNDQKTIGKTKQIILICREKQLREQNKIILKQNNVLDIITEIDKLIIKSNPGESITYRLSQLIELISKNNVLLIQALIKILNYEHPRHIKLKTIIALGLASHENLDAIAALNKEIESSPDLIYLFYTTKTLVAINPRNREAILLLRELMPTLHIYMQIEACELLMNDEEIAYDLFIKLIELIQSDPDDEVYYRACQTLKANINTDILYYSLLISKLRDCLTNKIYEDEFFRFRDCYELLWCYSQELSYKAFYEAWFQ
>NC_019751.1|WP_015197935.1|2719104_2720304_-|IS4-family-transposase
MLPQSYQKIFQKHLSEQQYLTLELLLLLIQAYRQVKLSTLANLFPQPITYESRKRNLQRFLVVGSLCVKLLWFPLVKYWIRQSQTGHNLNREQRRYYKQQKHKKYGYWMIGIDRTQWKDRNLFMVTLVWGTHALPLYWETLPHVGNSNFQAQKRLLSIALSLFKNYPVLVIGDREFHSPKLAQWLDNRGVYFALRQKKDLHFQEESDEEYQILKDKGFKPGMSKFYIGVKCNKGDGLGLFNLAVYWKRKYRNQGSQQPWYILTNLPTFKQTLEVYRCRWGIEQFFRDCKTGGYNLEDTKVNETRFLALVLLIVIAYSLGTMYGQRMQILGIETYAGRIKQHKDKYPRQSDFSFAIYGQRWIYAMELWADLALGLIALKPHKRLHFQRGFHALSLMKQAL
>NC_019751.1|WP_015197937.1|2724440_2725487_-|MoxR-family-ATPase
MTDWKIFQGNSEPHDNINQLPPPPSWRKFLDVDDQIVAQTEQRWQKFCEESEHNIKDEERGKSFRIHTDKNNDRNTVINMVNAALYLRRPLLVTGKPGTGKTSLAYAVAYELKLGAVLPWYITARSTLQEGLYRYDAIARLQDVQMGDKSKDIGRYIQLGPLGTALLPSRRPRVLLIDEIDKSDINLPNDLLNLFEEGEFEIPELARISKEVNQVEVRTYDGIDVPIKAGRVRCQNFPFILLTNNGERDFPPAFLRRCLRLNMPYEPDADALKEIVKAHLGSDTITKDEEKINQLIAKFRTLRESGDIATDQLLNAIYMVTREFKPEQAEEQDLIEVLLKYLTSAEDR
>NC_019751.1|WP_015197938.1|2725508_2727032_-|hypothetical-protein
MNINEIEINAIFDKITDNQHTAADLLVLRKTLNAGDKSTLKQLGKYITNIEEGKDIHIGDRTYNQWDKDAMEALVKAIQATSGIHQNTQDGDVAARDIDKRNVYKNCTFIQLLSSDSNFSNLSQESLNDLDFSRIPQESIQQAYQEALPPDAGVWGLEENNITQILQKLEQFRRLFDFFNRLSQDKNVPQEIRNKLNVVAEELALKKYPDENKNKLPADFVSNKEGQLQSYLIATLERCSDNEDFLLNAWLIIDDSIPGNNLSKFTSLLAQDEQQQGTLCKFNDIPKQLNKFLKTSLKYLRGKQYQLIIEIFLPSDLIGTEVDRWKISDPIVEEITLGIKYPIRLRSLERLDIDYLDSYLSDWYKYWDKVKTVLHNEPIQELFAHLQEMETFNWKSLRNNLQEKIGLKLTCAPPKAKTKELFKAILTATTPIAIWTRYDIPNFDHVSAIDEILTFKPLCHLCESVRQTREKADAQTEEHLGFHLALLWEDPYRLTPNVMLELKTPGQ
>NC_019751.1|WP_015197939.1|2727045_2728014_-|caspase-family-protein
MGDNLTKFSNGYALLIGVGESKYAPLSLPVTVKDTQGIYAALIDPELCAYPDDQDHIRVLNNQEATKAAIVDGLSWLKEKAESDKNATIFIYYSGHGWVDKNTQKYYLLQHDIKPTKLASSALAAEIFTDALREIQAERLLVVIDSCHAAGMATSKDADLELEEEFDDFIRVAPSKGFIDELKQGKGRVVFTSSKGEQKSYLKDDSCSIYTYHFLEALQGAGNKSGDTEVRVSNIMNHLGKAVPESARQYNVEQVPHFDLDAGDFAIAQLRGGKGLPSKGWDEVRSEATQKINKIADVINQHGKFITNINEAHGIHIGDNYS
>NC_019751.1|WP_144051033.1|2728074_2729019_-|hypothetical-protein
MFSNRRANIVSSVFADIKVIGECEEPEWIAAKLQQMQDPDFRGDVLENMNETPGGKGILEFLNLVQDQPWMYASHKFGYIAPRKPGSMKPQIIQHPSAIAADTSLKNSSINIRLDRLHIAKYPGGGTHNVMVTFAARNQVADTQETVSFSQTYRVQEGQSAGIAGYPVFIGLNVGSQGVAFECSTVNVKNNEDQAILSTLESSPFQSGLKLLTTAQPAIAPFTEITVGVVKMLAQRNENVAVQKFYLGLDFENMAMGCRLAEGNYIAIQVPDEIAIDWKQWIYKPDLGVIVHKSDDYETLPYNYVIFRVSRYEN
>NC_019751.1|WP_041740433.1|2729405_2730620_+|hypothetical-protein
MNQGIVKTETQQDILKDLMVARDLTTGDVTQQNIQNQIILLVNNLDDGTINKAFSATVPDDWYIWRNTYKTVNEALKQLEEIPYQNPSDTPLLKFASLLTQDNNIPESIREKLKQLLTNQAFKTNKKSPSTQSLHSYLLIQLRPQVTNELFVKAWFIPDDTIQDPWERFKPLTVDEQQPEIPFVPEELPQLLGNLLQQCFDEYLQGEATELTIEIFLPRDRLCDEVEKWSYQDSEGLDITIGEEHRVVVRSYDRLKTLRKQQGSYWKKNWENLQLIWQDIPCIEQITTISQACFDPNHLRKSLIEKIILKVCCNLSNSDRDGLLKAIHSAGTPIVIWSRCEVTNLKNPHHFDALLEQPLRELSARIKEQRLAADHEMHLGNHLVLLWDDPNRIPPNSALEFSAS
>NC_019751.1|WP_015197942.1|2730634_2731576_+|MoxR-family-ATPase
MSDWLIFQGTEKPHDGIKNLPSAPKWREFGEEKEKQRGETFQVRRNEIELVNAALYLRRPLLVTGKPGTGKTSLAYKVAQELQLGSVLQWAITTRSTLQQGLYRYDAIARLQDAQGKDNTRDIGKYIQLGPLGTALLPSPHPRVLLIDEIDKSDIDLPNDLLNIFEEGEFEIPELARLPEEYETVKVRGYDGGVANITKGRVRCTQFPFVLLTSNGEREFPPAFLRRCLRLTMENPDAKALEKIVRSHLGDGVMSEAEALIDQFIQLRDKPDAGDLATDQLLNAIYLVTRERSPVGNDKERLLKALMAYLTTT

Crispr_ID: NC_019751_13

• CRISPR_ID: NC_019751_13
• CRISPR_location: 2924934-2925044
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_13

Consensus_repeat	Method
ACTCGCGCCGACTGCGTTAAGTCGGATTAGTTGGAAACC	CRISPRCasFinder

spacers of NC_019751_13

>13.1|2924973|33|NC_019751|CRISPRCasFinder
AGATTTTAAGATAAACAGTATATTCTCTCTCTA

CRISPR arrays and Neighbor proteins around NC_019751_13

CRISPR arrays

The CRISPR arrays of NC_019751_13

>merge|NC_019751|13|2924934-2925044|CRISPRCasFinder
ACTCGCGCCGACTGCGTTAAGTCGGATTAGTTGGAAACCAGATTTTAAGATAAACAGTATATTCTCTCTCTAACTCGCGCCGACTGCGTTAAGTCGGATTAGTTGGAAACC

>NC_019751|13|12|2924934-2925044|CRISPRCasFinder
ACTCGCGCCGACTGCGTTAAGTCGGATTAGTTGGAAACC	AGATTTTAAGATAAACAGTATATTCTCTCTCTA
ACTCGCGCCGACTGCGTTAAGTCGGATTAGTTGGAAACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_041739473.1|2932991_2933228_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198101.1|2925688_2926363_+|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl|CDD|378065
NC_019751.1|WP_015198104.1|2928776_2929883_-|peptidase-C14-caspase-catalytic-subunit-p20	unknown	unknown	gnl|CDD|226700
NC_019751.1|WP_015198093.1|2915172_2915658_+|hypothetical-protein	unknown	unknown	gnl|CDD|373079
NC_019751.1|WP_015198091.1|2914410_2914794_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_144051116.1|2926331_2926976_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198108.1|2934776_2935289_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|182099
NC_019751.1|WP_015198107.1|2933828_2934680_-|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|366857
NC_019751.1|WP_015198094.1|2915808_2917272_+|ThiF-family-adenylyltransferase	unknown	unknown	gnl|CDD|366360
NC_019751.1|WP_015198099.1|2922517_2922757_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198105.1|2929907_2930327_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198109.1|2935504_2935969_-|HXXEE-domain-containing-protein	unknown	unknown	gnl|CDD|379370
NC_019751.1|WP_015198005.1|2912464_2913805_-|IS4-family-transposase	unknown	unknown	gnl|CDD|379252
NC_019751.1|WP_015198106.1|2933314_2933806_-|ATP-binding-protein	unknown	unknown	gnl|CDD|379324
NC_019751.1|WP_015198092.1|2914866_2915064_+|hypothetical-protein	unknown	unknown	gnl|CDD|316933
NC_019751.1|WP_015198103.1|2927055_2928300_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198100.1|2922779_2924519_-|HEAT-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NC_019751.1|WP_015198098.1|2921725_2922334_-|hypothetical-protein	unknown	unknown	gnl|CDD|226125
NC_019751.1|WP_015198096.1|2920654_2921551_+|DUF4351-domain-containing-protein	unknown	unknown	gnl|CDD|316753
NC_019751.1|WP_015198095.1|2917497_2918529_+|M48-family-metalloprotease	unknown	unknown	gnl|CDD|320694

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015198101.1|2925688_2926363_+|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl|CDD|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	5.79847e-35
NC_019751.1|WP_015198093.1|2915172_2915658_+|hypothetical-protein	gnl|CDD|373079	pfam14462, Prok-E2_E, Prokaryotic E2 family E. A member of the E2/UBC superfamily of proteins found in diverse bacteria. Analysis of the active site residues suggest that members of this family are inactive as they lack the characteristic catalytic residues of the E2 enzymes. They are usually fused to or in the neighborhood of a multi/poly ubiquitin domain protein. Other proteins of the ubiquitin modification pathway such as the E1 and JAB proteins are also found in its gene neighborhood along with a distinct predicted metal-binding protein.	4.53455e-05
NC_019751.1|WP_015198095.1|2917497_2918529_+|M48-family-metalloprotease	gnl|CDD|320694	cd07335, M48B_HtpX_like, Peptidase M48 subfamily B HtpX-like membrane-bound metallopeptidase. This family contains peptidase M48 subfamily B, also known as HtpX, which consists of proteins smaller than Ste24p, with homology restricted to the C-terminal half of Ste24p. HtpX, an integral membrane (IM) metallopeptidase, is widespread in bacteria and archaea, and plays a central role in protein quality control by preventing the accumulation of misfolded proteins in the membrane. Its expression is controlled by the Cpx stress response system, which senses abnormal membrane proteins. HtpX participates in the proteolytic quality control of these misfolded proteins by undergoing self-degradation and eliminating them by collaborating with FtsH, a membrane-bound and ATP-dependent protease. HtpX contains the zinc binding motif (HEXXH), has an FtsH-like topology, and is capable of introducing endoproteolytic cleavages into SecY (also an FtsH substrate). However, HtpX does not have an ATPase activity and will only act against cytoplasmic regions of a target membrane protein. Thus, HtpX and FtsH have overlapping and/or complementary functions, which are especially important at high temperature; in E. coli and Xylella fastidiosa, HtpX is heat-inducible, while in Streptococcus gordonii it is not. Mutation studies of HtpX-like M48 metalloprotease from Leptospira interrogans (LA4131) has been shown to result in altered expression of a subset of metal toxicity and stress response genes.	1.10369e-44
NC_019751.1|WP_015198108.1|2934776_2935289_-|GNAT-family-N-acetyltransferase	gnl|CDD|182099	PRK09831, PRK09831, GNAT family N-acetyltransferase.	6.40438e-20
NC_019751.1|WP_015198107.1|2933828_2934680_-|nucleotidyltransferase-domain-containing-protein	gnl|CDD|366857	pfam01909, NTP_transf_2, Nucleotidyltransferase domain. Members of this family belong to a large family of nucleotidyltransferases. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalyzing the addition of a nucleotidyl group onto the drug.	3.91888e-08
NC_019751.1|WP_015198100.1|2922779_2924519_-|HEAT-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	3.14857e-15
NC_019751.1|WP_015198109.1|2935504_2935969_-|HXXEE-domain-containing-protein	gnl|CDD|379370	pfam13787, HXXEE, Protein of unknown function with HXXEE motif. This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.	2.48205e-05
NC_019751.1|WP_015198005.1|2912464_2913805_-|IS4-family-transposase	gnl|CDD|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	2.62831e-61
NC_019751.1|WP_015198106.1|2933314_2933806_-|ATP-binding-protein	gnl|CDD|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	6.07171e-29
NC_019751.1|WP_015198092.1|2914866_2915064_+|hypothetical-protein	gnl|CDD|316933	pfam14453, ThiS-like, ThiS-like ubiquitin. A member of the ubiquitin superfamily that is often fused to the ThiF-like (E1)- ubiquitin activating enzyme and is present in gene neighborhoods with components of the thiamine biosynthesis pathway.	6.62237e-06
NC_019751.1|WP_015198094.1|2915808_2917272_+|ThiF-family-adenylyltransferase	gnl|CDD|366360	pfam00899, ThiF, ThiF family. This domain is found in ubiquitin activating E1 family and members of the bacterial ThiF/MoeB/HesA family. It is repeated in Ubiquitin-activating enzyme E1.	1.49679e-22
NC_019751.1|WP_015198098.1|2921725_2922334_-|hypothetical-protein	gnl|CDD|226125	COG3597, COG3597, Uncharacterized protein/domain associated with GTPases [Function unknown].	0.00184149
NC_019751.1|WP_015198096.1|2920654_2921551_+|DUF4351-domain-containing-protein	gnl|CDD|316753	pfam14261, DUF4351, Domain of unknown function (DUF4351). This domain is found in bacteria, and is approximately 60 amino acids in length.	2.22019e-22
NC_019751.1|WP_015198104.1|2928776_2929883_-|peptidase-C14-caspase-catalytic-subunit-p20	gnl|CDD|226700	COG4249, COG4249, Uncharacterized protein containing caspase domain [General function prediction only].	8.79827e-19

Protein sequences

>NC_019751.1|WP_015198100.1|2922779_2924519_-|HEAT-domain-containing-protein
MNPRIYFALSLLAVLTSSITKVSAAISHTKVAPIPSVISQSLPPTKKPIIVSELVEKLRIADMEERSKIIQQLSDSQENSPENIIPELIKALSDPDPLVKSAVAEVLGNFTDRAVAAIPALIEMMGSSQRAIIPSPYLVFPRISQAIAPIIPPPISASNTPRIPPTPPKNPENLLRITAIAALGKIGLPARTAATQPLTQALQDPDPWVKLNATWALAEIGASTPILNYWLEAIQHPNPELRRNAAIIIQDSRSLLRKSFGAEANTNIAIVLVSALKDDDYAVRDAAKSALEMLGTKALPGLIQGLSAPEPLVRLEAVKLLGNTEGTAQPAVSTLVKLLKDTGRYVPPKSDISNVFLLPDVQLPSFSRKYPLPPDNPEKMVRINAAIALGQIGDSQAIPALTTVLKDNNPWMQLASNWALIRLGQNQGLPVIGKLVQHPQAKVQRDALYQLKYYGSQSAPYLLPYYKAQLDSNDDEKRNNAIIGIGDMGATALNLVPKLRTILMGNRKNSSGYAATILGQVAQDTATAWHKGNLSPQQRQQAITEFAKVLQIMEAPKAKFNRQPRDRVRNALTTLRNSK
>NC_019751.1|WP_015198099.1|2922517_2922757_+|hypothetical-protein
MHSYQIKLKGESISDVREKLNEKKRGRDWAGINWQGESSTLSGADAIAIASLCKNHKYRKPSTLDDGRVIFFDGNCVNK
>NC_019751.1|WP_015198098.1|2921725_2922334_-|hypothetical-protein
MNKESMPKSQIFSGLVAAEAGIYEQLVSLVGEDAKKAVETIRQHSYISATCDVLVVAPGADLLAFVANTWTMYARINSALGISLSKNILKSVASAIGTNILSIIPGMILSSVGGSILKIVPGLGTAGGMAITGTTFYALSTVMGWTYLKAIMFLVSSDVPINEKNLKVATKQVTKDKDFIREIYDSAKSNFQQDQQDSANND
>NC_019751.1|WP_015198096.1|2920654_2921551_+|DUF4351-domain-containing-protein
MTRFPHDEFAKGFLESLLSPFGKVQTSFKIGSEVREVDIYFQPNPQVESDLALGLLGKLAKNSLIFEPFRNPVKTQQIRFCMGKLYDLHADLFRESKRNKQPEPKDSELPCLWILTPTLSEAILDGYGAKLAPEFTPAGVYLVNPSYKFGIVVIHQLQKTPETLWFRLLGKGNVQSEAIVEVAKLPENHPCRQNALDWLGNLKVILESREVLEPEERDLMMQLSPLYLEKIRAAESLGRQEGQCELLLRLLNRRVGSLSPEMQDQVKALTLARLEELGEALLDFTSLTDLETWLNQLH
>NC_019751.1|WP_015198095.1|2917497_2918529_+|M48-family-metalloprotease
MKFRNAKGNLAVITIMMLFCLSVFSYGIYASYYGLQLFQQGAFNFIIGLFFLGCVGVPSIYWVVSTIYRYFAAVPSYINQRQIRVINPHLLHEKGLYFETEKSLCAAVKELAKAEGLPTTPVVGIELCDDNPNAYAVGATRSYAMVVATTGLINQLNQREVAAVMAHELGHIANLDTMAKTLLSAALDGVMLILFTPMMMIVWYFGRFAALLMLAAGLIYGLLGNWQHATGFFVGVLVWIILMMLPMITKFLVTLLTFWHSRWREYHADAVAARLTSVDDMVSALATLDRLPFQPPKKNREQMSTLWIRVAMNEETGTFHWLKHTHPPIHKRIEALRRGLYLR
>NC_019751.1|WP_015198094.1|2915808_2917272_+|ThiF-family-adenylyltransferase
MKKSTAISLHIPPKMWSEFRESMLKSRMFNEEVIGFLFCQRHQVSKSKIRYIPKTWVVPASDCYEHQSTSGLVLKQHFHSYLLENHLQVGLDVVHIHTHTGQGIPDFSHTDDRYESEYARFISSNFPKKPYLISGVFDENLQSGQFRIWDRKGQKFEYLNFCNSLFEVSKFEDVINHDDSIFARQKIFGKGNQKALNQLKVLLIGCGGIGSIFAELLGRLGVKNWVLVDPDRLETTNLNRMPSATQEMVEQQWHKVHYVKHLIKKIYSEGSSVKTIVTTVESELAKQEIATCDLIVVATDNHFSRKTAQELALQYMRPLVCLGTHIDMKSDNTPRMYCRVTVPPLGGAWCLMCGNIINLQRAALESAPLAINQIAANAGYLEGVNDPAVFWLNSICASTGVGVIHGMVSGFLNVDSGIDWIYEFPDGNWRKTNTEYLQNDDCYFCGMGSLEEVVEDSDFEDSDFEDSDFLGSDVEDSDFDNSDFFVW
>NC_019751.1|WP_015198093.1|2915172_2915658_+|hypothetical-protein
MAVTISQEKAGFKPSQRIIEELKLLEKVARNVIVGSKTVGDIKYIAVLIKGMPLSSKKFTVSNTDVLFLLPPDYPRLPPIGCYLNYPWNTLGEGDHHFTRQSYYGAPFLSEEGWYWYCVGLGGGFNHDVWLNSWRPSNNPENGHNLATLFVTARHAINSDD
>NC_019751.1|WP_015198092.1|2914866_2915064_+|hypothetical-protein
MRAIVNGKLVDLPEGTTVEQLRKKLPEIGQDDVMEEGFSGTRPLKNNEALKEGSKVWTVPKIVKG
>NC_019751.1|WP_015198091.1|2914410_2914794_+|hypothetical-protein
MGTVNGKLINQKINHFDELTQKTERINQRCEDLESQVIAITKHNYTQHLQKLNQEINSHKSYLQKLEQKIGFLEDVASRQAKQLFFLKISGVIALVSLWLIFGMNNQPEQSKTKPHRKAESLEFTQS
>NC_019751.1|WP_015198005.1|2912464_2913805_-|IS4-family-transposase
MFDILSLLQCFLPQINATTMKQLNQIILAMLAMSGRVTMLGISRWTGSGGSYRTMLRFFHTVIPWATLFWLFFRKHLFRANEVYLLAGDEVVVSKSGKKTYGLDRFFSSLVSKPISGLSFFTLSLVSVEQRHSFPIQIEQVIKNDIEKSSVSPRPEIKAKEKRGRGRPKGSKNKNKTEVILTSELLRIKKMINELVKLVANFIPLTYLVLDGHFGNNNALQMARQVNLHIISKLRHDSALYIPYQNPDPNHRSRRKYGDKLDWRNISDEYLRQSSIEEDIQTDSYQATLLHKEFAQSLNVVILVKTNLKTNARSHVILFSSDLKLSSEKIIDYYKLRFQIEFNFRDAKQFWGLEDFMNIGQTAVTNAANLAFFMVNLSHHLLADFRILNPDSGIIDLKAHYRGFRYVHEILKMLPEIPEPILLTRIFAKLTSLGRIHHVSTGVESS
>NC_019751.1|WP_015198101.1|2925688_2926363_+|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MSRKQIRNVPASIRSQLLHLSKQRGEDFNYLLMHYGSDRLLYRLSQSPYQKQFILKGATLFRVWNGEPHRATKDLDLLSFGANDVSSLMEIFKEICRQQYDQDGISFHEETVRGEKIKEEQEYEGVRINLQAKLDSTKISIQVDIGFGDAVTPLPEEALLPSILDLPAPRLQIYPRETVVAEKFQAMVALGISNSRLKDFYDIWFLCQSFEFQGNLLVYRDTSY
>NC_019751.1|WP_144051116.1|2926331_2926976_+|hypothetical-protein
MYLFTETQVTENTRQALLNFWRDSIIKLCTPHSYLNFYTREQTVSIWWLHWLLDSITSEKTGKAWFGQQITEWLANLPGDRGNLGGEYGVLCLLTKDLSDILYQGKCPYPKFYEVVVAPSQQSTPDDTSRRKYLQEYAPLDLWERVMDYWRANLHNFVPKPEMSQNSDYSTNAAWMSALKELSPQSYQRLLSEWKVNHQRRRNLWKAMGSLGLM
>NC_019751.1|WP_015198103.1|2927055_2928300_+|hypothetical-protein
MTLKTTILAIVGSLTLAIPQTYQYTFAETPSKLSQAQPSLKASGIPKSVVLQVRQDMAKQLNFKLTDVRFTRIESKIFDACLNLPAKNEKCKEIGYKGWAIRVGTGKQSWLYHAVSPQNISNNFRINWLQSLPKDVKQTVISNVTRFSKLPLGKIKVVSVEPRIWKNNCLELAKTDQRCDSTKTPGWLIKLKSDTYGGKLRLNEEKPSQWVYRSDLDGKIVELDLVSSMGNLSQKVNANILSDAAKRSQTQPSAWRVDKIQNLQWSTRSGDGPSRPITGAVPVENYTFGWKVLVSSPQQKWVYYATKNGFEFDAPKSVPSYLVEEAIKAASVQTGKPASNFRLHWAELLTWDDTCLGVTINKPACEKTPVLGWRISLMESNSTLFTFHSRFDRDVRFAGSSPWFFPPSANPGGR
>NC_019751.1|WP_015198104.1|2928776_2929883_-|peptidase-C14-caspase-catalytic-subunit-p20
MGKYALLIGIDTYGEGLQPLPAASKDVAALREVLLNPQMGGFDEAKPMINPTQSEMAREIELWFQDRQPEDLVLLFFSGHGVKDDRRDLYFAAANTEKQRDRLLVSTAIPARFIHDCIRSCKAKYQVLILDCCFSGAFGDSIPRDDGEIPLKEQLGAEGRVVLTSTSAVDYSFEEKGADLSIYTRYLVEGIATGAADENEDGVITVDELHRYAGRKVKETSPVMSPTLITLKDEGFRIRVARSPQDAPSLKYRKEVEQIAAEDEGEADSILSRHKNVRLRIRMNGGMAWNVFRIPRYVYLDHHILILKTKEISFTVNAETNIGTHTLCIGESSYMHSRRLHFPEAGYYEVYCRSDFIKGLIISDPEKL
>NC_019751.1|WP_015198105.1|2929907_2930327_-|hypothetical-protein
MSEPCSVLIDFSEAGLDLDRSDLESYLLTIADEMESGDLVQSARLARDEDIPEAAKSGVAAFLIGILTTEINRKNLGKLMDYLGNLRYGKTLTLSGEIDGMTYNIEYRNKQELDQAADTIERLTNLRVKIREQQTKPEN
>NC_019751.1|WP_041739473.1|2932991_2933228_-|hypothetical-protein
MAGDGQRYEFQTTCDRSYLLSEIPAAIQYLEQDQVMRIDSNVRRYMVRKFPDEILLISLFGCYMKNFWISAINRLKSL
>NC_019751.1|WP_015198106.1|2933314_2933806_-|ATP-binding-protein
MYSKGTLIFFCGKMGAGKSTLSRQISQELNAILLSEDDWLSTLYPEEIKNFDDYLKYANRLKPLLISHIRNILNSGVSVVMDFPANTKNQRAWFKNIFLTENIPHRLIYLEIDDKTCIEQIAKRRETNPERSVFDTEEVFRHVTTFFQPPSADEGFSIEVVKR
>NC_019751.1|WP_015198107.1|2933828_2934680_-|nucleotidyltransferase-domain-containing-protein
MNQQLPDFIHDVVERLQSIEGIASVALGGSRARGNHTPKSDVDLGIYYQPDNPIDVIALNKLACELDDNHRPNLITPIGGWGKWINGGGWLKIKNMPVDFLYRDVAQVDRVIDDCRLGKITIDYQPGHPHGFVSSIYMGEVAISLSLCDSHGVLAALQAKTQPYPIELQKATIDTFAWEISFSLLVGKKSIARGDIAHAAGCCFRSIACINQVLFALNHEYLLNEKGAVAMANNFAVCPHNYQQRVESAFALLATKSIAEAVAILEEIELELSQWYGERRLEM
>NC_019751.1|WP_015198108.1|2934776_2935289_-|GNAT-family-N-acetyltransferase
MKQSDRSQDLREYINSQIAIRLFEERDAEQIALLFHDTVREINIRDYSSNQVRAWAPDNIYFRDWVKMCSSRFTYIADDMGIIAGFGELEANGHIDCFYCHKNYQGCGVGKQIYRAIEAKAIELSLSRLFVEVSITAKPFFQRMGFSIVQKQEVTCRGESFVNYVMEKSL
>NC_019751.1|WP_015198109.1|2935504_2935969_-|HXXEE-domain-containing-protein
MALQNLSVWLLAFALILHTVAEVWLPAYEKVKPDWRLVLFDTGLFLENIPVFLFAFVTAFAGWQWQILGMILPAVGLTHPLLDHLFLSWKYQQLRPGTLSGLFLLFPLSIWVYYLGYTRQLLSLQAGLISGVIGLAISVRLLWEVRKVPGSQTS

Crispr_ID: NC_019751_14

• CRISPR_ID: NC_019751_14
• CRISPR_location: 3151872-3151960
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_14

Consensus_repeat	Method
GCTTTTTGCTCTAAAGCACTTTC	CRISPRCasFinder

spacers of NC_019751_14

>14.1|3151895|43|NC_019751|CRISPRCasFinder
AAGCCCATTAATACTAGAAATATCGTGATTATGAATCGTTGGA

CRISPR arrays and Neighbor proteins around NC_019751_14

CRISPR arrays

The CRISPR arrays of NC_019751_14

>merge|NC_019751|14|3151872-3151960|CRISPRCasFinder
GCTTTTTGCTCTAAAGCACTTTCAAGCCCATTAATACTAGAAATATCGTGATTATGAATCGTTGGAGCCTTTTGCTCTAAAGCACTTTC

>NC_019751|14|13|3151872-3151960|CRISPRCasFinder
GCTTTTTGCTCTAAAGCACTTTC	AAGCCCATTAATACTAGAAATATCGTGATTATGAATCGTTGGA
GCCTTTTGCTCTAAAGCACTTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015198268.1|3154679_3156584_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198266.1|3153595_3154279_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_158333150.1|3148632_3148953_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198257.1|3145850_3148334_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|236093
NC_019751.1|WP_015198271.1|3157966_3158692_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198255.1|3145145_3145382_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198269.1|3156583_3156910_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198265.1|3153340_3153595_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198272.1|3158760_3159264_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198261.1|3149726_3150851_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198260.1|3149196_3149730_-|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl|CDD|119407
NC_019751.1|WP_015198251.1|3143170_3143629_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|222893
NC_019751.1|WP_015198267.1|3154512_3154686_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198270.1|3156911_3157970_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_158333149.1|3148384_3148552_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198264.1|3152816_3153221_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198252.1|3143719_3144058_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_158333148.1|3144766_3145078_-|hypothetical-protein	unknown	unknown	gnl|CDD|370166
NC_019751.1|WP_015198263.1|3152355_3152814_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198253.1|3144358_3144709_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015198260.1|3149196_3149730_-|N-acetylmuramoyl-L-alanine-amidase	gnl|CDD|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	2.47308e-55
NC_019751.1|WP_158333148.1|3144766_3145078_-|hypothetical-protein	gnl|CDD|370166	pfam08872, KGK, KGK domain. This presumed domain is found in one or two copies in cyanobacterial proteins. It is named after a short sequence motif.	0.00944457
NC_019751.1|WP_015198257.1|3145850_3148334_+|AAA-family-ATPase	gnl|CDD|236093	PRK07773, PRK07773, replicative DNA helicase; Validated.	2.89003e-38
NC_019751.1|WP_015198251.1|3143170_3143629_-|helix-turn-helix-domain-containing-protein	gnl|CDD|222893	PHA02587, 30, DNA ligase; Provisional.	0.000503104

Protein sequences

>NC_019751.1|WP_015198261.1|3149726_3150851_-|hypothetical-protein
MPLFVDWARDVLENILQAIPSSENPALIKGIRSKFRDDFSGGTLNADNWEVIQLGSGQAITVSNSELQINTGTSTGSTIIRSKKSFSIPVRLSFVFYLSQRIANQNFIIEIVDSAGENYARWSFNGTNPNNSIPSVANFGIAGSAIAVNTANATSTYALYEIDIGLNEVIFATRNLEAGNARASSYSRNRKIPDPNLEYFIQVRVENSGVVSNTTVFVDSFSYQIPELLSAEITGGRGSTVGSEAIPVIGVGGNFSINGAIAVSTIGTITALDNVVYSTETIATLLANATFTGASKDTAGRKNLTVFVNSDQTGTLFVDWSADALTFFPFPGQACAANTSVVYQQETPLRYYRIRFVNGATAATPKIYTLLRFL
>NC_019751.1|WP_015198260.1|3149196_3149730_-|N-acetylmuramoyl-L-alanine-amidase
MKIAIDPGHKCPPDTGAEGFLIEQDLNQDIYNELSWLLIDAGVEVVNCRPTTRVKSVTESLSRRCAIANAAKADYFISIHHNAGGGTGSEIFAISPEGKKLAASVLAPLCALGFRNRGVKERGFLVLRKTNMPAILIEVCFIDNAADCQLWEKLKAKQIASAIFKGLDDCLQITSQS
>NC_019751.1|WP_158333150.1|3148632_3148953_-|hypothetical-protein
MATLLEKIQELQAGQAVSNEKIQALVAASTEEREQVGGLVTLSVAQQETITQLNEKVEELTALLDGSNQETTAAIEAVESLLESTMQQSENISGAIEEIKAIYNPE
>NC_019751.1|WP_158333149.1|3148384_3148552_+|hypothetical-protein
MIENGDSFFCEECGYVGYIPEVDLDINDPDFHDHYEDGTPVIEPTDKTPNINSEH
>NC_019751.1|WP_015198257.1|3145850_3148334_+|AAA-family-ATPase
MVAIPYKADVLDFTPTPNELPPRNEQAEDAILGGILLDPTAIFRIWGRLKPEHFQVTANREIYKACCKLARQNKPTDLLSLSSYLNDKKLLAEIGGRNKLANLVEGTVSAVNIDELAALVIEKAVRKDLIKLGNETIRLGYDTQVDIEEVLESFKRRVETVVELETVKTEEELIKSRHDRLIDKLKRIYTTVAEPSLKHMRLKALADDTRTSIGFLESLYLKSLVGTCTKLMDYEDLKQAAGSSVRRWLQQGLVPLATTILLAADGGIGKTKLVYSLAKNLIEGTQFGDFLATGEKRRILFYQGDEQEGDMLQSLQMLGYEQGDLTKYIRIRFGWSFENMATLTQDLNEFKPDFVVFDSLSFGSRFSTVRESDSEFARPLLEASGLAAQHNCTFLFIHHANKGGEVRGTTAIRNAVSEVWRLTKSNQPEDTQYDRVLEIDKSRSRSSGKRYKLYFDPDTLAFKFLGEEVAPNADVSSRGTRGKILEYFRQHPNTRFTAEEISQFANISSGNCRRTLNEITSDGLLSVERKPGKTNCYYLEFTNGYNLNGSQIIYSTENQGLQPLSVPLIDDHTKYPDHPADHPADHPLKLDGISDSGDGDRVIGKNDPEKKGTPKNDGDQNRSPDHHRLEDLQNIGSRGDRVPDPLTDHPITSDHPSNAPLKSELIHVEAKPSTLEKTATTELSEPIQQPLFPGQETQVQTKQLEQIRKIYNTCLGQVKAMAEEIDPKNWRFTIITPDGIKAVEKTEKLGAYKPDNKLKNVLDNWLKSLTFEVIKTDCSPTQWVSGCKWVESIDHHNAMQKRHKFITPDGTLIDAFGFGCDRIRVMS
>NC_019751.1|WP_015198255.1|3145145_3145382_+|hypothetical-protein
MNKQQINLTPSGVAQAEALAELTVYLEREFNLSFDEARWMSAGIIHNLTCAIKANPESHRGLSEIAGEIKNQKHSLNN
>NC_019751.1|WP_158333148.1|3144766_3145078_-|hypothetical-protein
MENRIVLEDGDVVNVSPNQNPTGSATAKVGDIKKSIGSKLGNDQMSWGFNGVHGEALIQIGGGGWMKGRMVLQIMFYPSQSLPSQQKTQVSSPLDDLRKELNI
>NC_019751.1|WP_015198253.1|3144358_3144709_+|hypothetical-protein
MGNVNGSENKNSCTRAEEKRSLNNADSRQSGLFRRSSCNTGHKQKRVSRKDDSRTKNFGGDSTAGGMLRHLISNYREQVAQKDLEIQVALEEKIKLETKIKELESLRIELETASPE
>NC_019751.1|WP_015198252.1|3143719_3144058_-|hypothetical-protein
MTQQLINLVTDIEPIMDYLDFQPGEDPFIDGLVERHGNHLQTLTQREKLYMVAFLANSLSLEADGDIGNRIIQLSQDCFSQLGGTDLLALIAALSDQLRGGYYAESNNKTGQ
>NC_019751.1|WP_015198251.1|3143170_3143629_-|helix-turn-helix-domain-containing-protein
MAAKQTPKSTKTTPEVAQEIGVAESTVRSWLSRYTCFVEGHHYIKEESGRTLWLEAGVEFLKTKSGEFSTATETVTINPGEEIIEPILEATAQQLAYIYFEKLPQRVVERIQQMLSNPSPQDAEVLQRAMQRSIAAGATHLIANSTTRRLQG
>NC_019751.1|WP_015198263.1|3152355_3152814_-|hypothetical-protein
MSLNSSLWQQNYQQNFTVATNGIRFVPLPAIDIPVTFDKSLVAISTSSFNSPPKWVTGGWVSQKIYTGLTIENNNDATLTNQRVFLNKLNLFKFSLDLASSYTLNYAFPRWIKDISIAIWEYQGDISSYDPNDIPATLQRLEDKIDDLAGGF
>NC_019751.1|WP_015198264.1|3152816_3153221_-|hypothetical-protein
MQIVIPAKPNLDVLVDSAYSDWKSKHSSVVAAREEADSQAMAILQADFQKSLNEVLALDIQALLNIQFNQSLNKGVFAIFSFLNKQWSIYRFVHDDGTHWNLINDEIDLVCFPDCFQKQLLIELGKVKARTISP
>NC_019751.1|WP_015198265.1|3153340_3153595_-|hypothetical-protein
MLIETEEGLILPGHPDFNYYLQSKLPPDWREFANKHSDFAFVVRADGSGLLEIVNEDELEEYCEDGELDAREAEMEDDDLIFVP
>NC_019751.1|WP_015198266.1|3153595_3154279_-|hypothetical-protein
MAVYTRGKKRDILTYVAVYPTLLYGFKTKDFNNLAGITTANLVAQLGHLLGDFTPPAGSIRVIGANTPKPNRVTKRIANAGVGSQQSVSTFCSSETLTNAMSGGWNVTKQRRGVNLRPETSSKNTLTAIATLSDGSLYCYPMNKADYTTYAEPLGLTNSAGLGSISPAERGKLVSGSTIPRPGKAAIEVSGGGIFSTFYSTANKDALATAGFSILTDESVFALAVTP
>NC_019751.1|WP_015198267.1|3154512_3154686_+|hypothetical-protein
MLSPFSRMVQYENLLEDFAMPYSVFGSIDRENLLEKYKKLSNKPTHYLETRYQHWQW
>NC_019751.1|WP_015198268.1|3154679_3156584_+|hypothetical-protein
MVKQRFTLPFQLPFPFQRPPTSPPSFPGMGIYGVRLPTPDNIRQGIFDAGVVGYKVDIVADNCNTAISVAPRYLSVRFPPVQIVHRNPYCRERQYPPVQLPIPDDKEEPGEMDEGCGVGMYFVYENYRLSYGDGGLERNAAFTRYVRGEVFRDLVELNFRRDINNDFVEIGEFNGEGYHIAATLNVRTFVKFNTSNARDNNITVEDWAASGGIPGNPNELNSIWSKEQQGNVTYFFRAGGRFIGGAGGIETDSSYTPLIVNENLDDFRLDDFRANFATANRQSSTKQDQTFIQYDKPFTETIISDYAPRKPELVEQGTTVFGTRFFVYSCYELSFDAERVRARELCVKSPPPPPDMSCNCCPNIQQNDELLRLILKRIGTPVSVQIFDENLEREGSQQATKTPETLFKASKLAVERTEISNRLIGIENFPVKVPDTMIEPFKEGIFENIFGFFEGEKERSLKSVTELIAWMAEQDSAVLGQFHQVVEFEQDFDGDGNIQKETVVLPNVAETLKEVILLLVQLANNEGTKVHALAKILIEISNIKANLFKTMNTVVDIQDYLDYPTLTKTVEVPLAVDLTLDKETQDFVDFFKESKGKITYEDWDGTNSLHDNMLDLMQMATMLRAILYQRTEQE
>NC_019751.1|WP_015198269.1|3156583_3156910_+|hypothetical-protein
MADPKPNPQAEKISRRMKAKVDKLEKISDVLTDKQLPEGKIGEKLRRQRELERDTKKGAAARNKKFKEFDDWLDRQELINNSRQGAGDEVPYVKITRLVATTKDGRLL
>NC_019751.1|WP_015198270.1|3156911_3157970_+|hypothetical-protein
MPLPLVLGKAAMWGAKAAVGLAVSYACEKAVDKATGQENNPVGLACYLVGGGALGKAGKKGITKLVVKQPTVSRAITKNFFGQAVTGLIKLPFRGLGRVGRLVGGLTRRVLRNHLVQAGIFVGILSATINTTNFIVNFNINASDEELLKQIEARINSFYGLFGAAVGSSLGYLMCGALPGTVAFAFNPAVGALIMRDLDEEARSDIYAQAGAIGRLSFQTLVNAELTRQFMNARRYLKRDPNHPVTKILKNIMGKKTFENWGKSNQPSFTISENVINKSIDDNIKDKGLKQFTEELLENFTEACIESGFLIAQNLDSAIAANVLAQRQIIGKPVEVSIQLNAPQPPTPRRRN
>NC_019751.1|WP_015198271.1|3157966_3158692_-|hypothetical-protein
MEEIIVSGSEETVKPIITMLMGISQMLNNRDIGQFVGEPLEENIKAVPSLLTMKIVWYSAKEPPFQAPVGKRFIKAECNIPDVYKSKLKWETIKQLAGGANGYEWGEYLALAKLDNNRQMHVRGATKAIASKQLDNMLELTKAKVTSISVIQLTKAGRRASGQTLEIKPARIYPANFIIVNSKKIDATQQRIYRDEIATRKLSTLRGDYAKRGSQRIPLWTDKPPKDYKQILNNAFNIDVV
>NC_019751.1|WP_015198272.1|3158760_3159264_+|hypothetical-protein
MTAITPGSGASISAATLEGQLLELAVFLKIAEQSPSKNPNSRNFIGITFNLSTLIASITFSLPASPGVNSSGQLLTTATPYLQNTGFTPGSGGTFLSVNPEAYFMELVTALQINEANAAKNPALANNVSAVYDSDEQLFDGTATLPIEVSLQLDGSIKTIADEYLLD

Crispr_ID: NC_019751_15

• CRISPR_ID: NC_019751_15
• CRISPR_location: 3493010-3493138
• CRISPR_type: TypeV
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: cas14j

Consensus repeat of NC_019751_15

Consensus_repeat	Method
AGAAGCGCAAACAGGATGTGTAGCTGTGCTTCCGTCCT	CRISPRCasFinder

spacers of NC_019751_15

>15.1|3493048|53|NC_019751|CRISPRCasFinder
GGTTTGTAAGAAGCGCAAACATTTGGGAGGAAAAGCCCCTCAAATAGTTTGTA

CRISPR arrays and Neighbor proteins around NC_019751_15

CRISPR arrays

The CRISPR arrays of NC_019751_15

>merge|NC_019751|15|3493010-3493138|CRISPRCasFinder
AGAAGCGCAAACAGGATGTGTAGCTGTGCTTCCGTCCTGGTTTGTAAGAAGCGCAAACATTTGGGAGGAAAAGCCCCTCAAATAGTTTGTAAGAAGCGCAAACAGGACGTGTAGCTGTGCTTCCGTCCT

>NC_019751|15|14|3493010-3493138|CRISPRCasFinder
AGAAGCGCAAACAGGATGTGTAGCTGTGCTTCCGTCCT	GGTTTGTAAGAAGCGCAAACATTTGGGAGGAAAAGCCCCTCAAATAGTTTGTA
AGAAGCGCAAACAGGACGTGTAGCTGTGCTTCCGTCCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015198536.1|3482973_3483567_+|DUF1517-domain-containing-protein	unknown	unknown	gnl|CDD|369378
NC_019751.1|WP_015198543.1|3490028_3491084_-|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl|CDD|237376
NC_019751.1|WP_015198555.1|3501138_3502350_+|IS200/IS605-family-element-transposase-accessory-protein-TnpB	cas14j	-	gnl|CDD|223747
NC_019751.1|WP_051036677.1|3484671_3485625_+|hypothetical-protein	unknown	unknown	gnl|CDD|273456
NC_019751.1|WP_015198554.1|3500400_3500676_-|glutaredoxin-family-protein	unknown	unknown	gnl|CDD|368604
NC_019751.1|WP_015198552.1|3497243_3498638_-|histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_019751.1|WP_015198548.1|3494598_3495363_+|CHAT-domain-containing-protein	unknown	unknown	gnl|CDD|378942
NC_019751.1|WP_015198550.1|3496493_3496817_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198540.1|3488653_3489067_+|KGK-family-protein	unknown	unknown	gnl|CDD|370166
NC_019751.1|WP_015198539.1|3485942_3488369_+|dynamin-like-GTPase-family-protein	unknown	unknown	gnl|CDD|223771
NC_019751.1|WP_015198553.1|3498786_3500274_-|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	unknown	unknown	gnl|CDD|234660
NC_019751.1|WP_015198544.1|3491724_3492207_-|PAM68-family-protein	unknown	unknown	gnl|CDD|371813
NC_019751.1|WP_015198541.1|3489171_3489627_+|KGK-family-protein	unknown	unknown	gnl|CDD|370166
NC_019751.1|WP_015198556.1|3502638_3505350_+|hypothetical-protein	unknown	unknown	gnl|CDD|283306
NC_019751.1|WP_015198537.1|3483636_3484536_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198542.1|3489690_3489936_+|HNH-endonuclease	unknown	unknown	gnl|CDD|372995
NC_019751.1|WP_015198549.1|3495458_3496457_-|radical-SAM/Cys-rich-domain-protein	unknown	unknown	gnl|CDD|275025
NC_019751.1|WP_015198551.1|3496940_3497135_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198545.1|3492218_3492488_-|30S-ribosomal-protein-S15	unknown	unknown	gnl|CDD|180170
NC_019751.1|WP_015198547.1|3493182_3494187_+|transaldolase	unknown	unknown	gnl|CDD|183426

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_019751.1|WP_015198555.1|3501138_3502350_+|IS200/IS605-family-element-transposase-accessory-protein-TnpB	cas14j	-	4e-92	304.4	15.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_051036677.1|3484671_3485625_+|hypothetical-protein	gnl|CDD|273456	TIGR01129, Protein_translocase_subunit_SecD, protein-export membrane protein SecD. Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking].	1.94332e-47
NC_019751.1|WP_015198543.1|3490028_3491084_-|3-deoxy-7-phosphoheptulonate-synthase	gnl|CDD|237376	PRK13396, PRK13396, 3-deoxy-7-phosphoheptulonate synthase; Provisional.	0
NC_019751.1|WP_015198555.1|3501138_3502350_+|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl|CDD|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	5.74398e-59
NC_019751.1|WP_015198536.1|3482973_3483567_+|DUF1517-domain-containing-protein	gnl|CDD|369378	pfam07466, DUF1517, Protein of unknown function (DUF1517). This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.	1.92772e-34
NC_019751.1|WP_015198556.1|3502638_3505350_+|hypothetical-protein	gnl|CDD|283306	pfam05616, Neisseria_TspB, Neisseria meningitidis TspB protein. This family consists of several Neisseria meningitidis TspB virulence factor proteins.	0.00494709
NC_019751.1|WP_015198552.1|3497243_3498638_-|histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.56387e-43
NC_019751.1|WP_015198548.1|3494598_3495363_+|CHAT-domain-containing-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	9.8273e-10
NC_019751.1|WP_015198540.1|3488653_3489067_+|KGK-family-protein	gnl|CDD|370166	pfam08872, KGK, KGK domain. This presumed domain is found in one or two copies in cyanobacterial proteins. It is named after a short sequence motif.	2.03576e-39
NC_019751.1|WP_015198539.1|3485942_3488369_+|dynamin-like-GTPase-family-protein	gnl|CDD|223771	COG0699, COG0699, Predicted GTPases (dynamin-related) [General function prediction only].	7.21183e-39
NC_019751.1|WP_015198553.1|3498786_3500274_-|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	gnl|CDD|234660	PRK00139, murE, UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional.	0
NC_019751.1|WP_015198544.1|3491724_3492207_-|PAM68-family-protein	gnl|CDD|371813	pfam11947, DUF3464, Protein of unknown function (DUF3464). This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 137 to 196 amino acids in length.	2.01519e-83
NC_019751.1|WP_015198554.1|3500400_3500676_-|glutaredoxin-family-protein	gnl|CDD|368604	pfam05768, DUF836, Glutaredoxin-like domain (DUF836). These proteins are related to the pfam00462 family.	4.54863e-24
NC_019751.1|WP_015198541.1|3489171_3489627_+|KGK-family-protein	gnl|CDD|370166	pfam08872, KGK, KGK domain. This presumed domain is found in one or two copies in cyanobacterial proteins. It is named after a short sequence motif.	1.08467e-16
NC_019751.1|WP_015198542.1|3489690_3489936_+|HNH-endonuclease	gnl|CDD|372995	pfam14279, HNH_5, HNH endonuclease. This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.	8.3119e-16
NC_019751.1|WP_015198549.1|3495458_3496457_-|radical-SAM/Cys-rich-domain-protein	gnl|CDD|275025	TIGR04167, radical_SAM_domain_protein, radical SAM/Cys-rich domain protein. Members of this protein family have an N-terminal radical SAM domain (pfam04055) and a C-terminal pfam12345 domain. The C-terminal region has several conserved Cys residues, one of which is replaced by selenocysteine in at least five bacterial reference genomes.	7.97654e-177
NC_019751.1|WP_015198545.1|3492218_3492488_-|30S-ribosomal-protein-S15	gnl|CDD|180170	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed.	2.13431e-44
NC_019751.1|WP_015198547.1|3493182_3494187_+|transaldolase	gnl|CDD|183426	PRK12309, PRK12309, transaldolase.	0

Protein sequences

>NC_019751.1|WP_015198545.1|3492218_3492488_-|30S-ribosomal-protein-S15
MALNQQQKQEIFAKYQIHETDTGSADVQVAMLTERISLLSKHLQANKKDHSSRRGLLKLIGQRKSLLAYIQKGSREHYQGLISRLGIRG
>NC_019751.1|WP_015198544.1|3491724_3492207_-|PAM68-family-protein
MSAESNPKNNLPFEPKTKRQKPAKANNQPPVVKQGLAKKEQNQQLPFSKEEMAIPKVVSQRMIRRVAAFCGIPTFLGITTLVVSYLLVSFAHIKLPPIAVLLVNMGFFGLGVLGITYGTLSASWDEDRTGTWLGWNEFTTNWGRMVSEWRTTKQNKQKKA
>NC_019751.1|WP_015198543.1|3490028_3491084_-|3-deoxy-7-phosphoheptulonate-synthase
MIVVMKIGTPEAEINRIDQELSGWGLSPEKIVGRHKVVIGLVGETIDLDPRQIQDVSPWIEQVLRVEQPYKRASREYRQGDASDVVIHTPDGNVTIGEHHPVVVVAGPCSVENEQMIVETAKRVKAAGAKFLRGGAYKPRTSPYAFQGHGESALELLATASRESGLGIITEVMDAADLDKIVEVADVIQVGARNMQNFSLLKKVGAQPKPVLLKRGMAATIEDWLMAAEYILAAGNPNVILCERGIRTFDRQFTRNTLDVSVVPVLRKLTHLPIMIDPSHGTGWSEFVPSMAMASIAAGTDSLMIEVHPNPKKALSDGPQSLTPDAFDVLMRELSVVGKAMKRWEQVPAIV
>NC_019751.1|WP_015198542.1|3489690_3489936_+|HNH-endonuclease
MPKTPRIPIPKEVRKYVFQRDKFQCQSCGKTDTETKLSIDHIIPLASGGSNDMSNLHTLCITCNRQKSDQNDPRFRRYFET
>NC_019751.1|WP_015198541.1|3489171_3489627_+|KGK-family-protein
MENQFKILECHDDDVISFDQELLKYKDFKNKLKNKFLCQIDYLFEKDSNDQSTTERLFNLILTPFGKLNLSINLNSPLEGEKAEILRLGSNKWEKGKIRTKLVIEFLPEGDTVYEGSEIRMSIEFSPDEPETICQSASPLDDLRRQIQEIT
>NC_019751.1|WP_015198540.1|3488653_3489067_+|KGK-family-protein
MENSFQKIECNDNDVISFLGDYTYKVAKIKRAFVQVRNTSIGNLFHHELKNKGIILNLEKLHPKGYHSACEQWLNEGIDCEILNVGASAWKKGKMKIKISVEFVIEEDNTTINNETNFNHTPPESPLDDLRQMMIDN
>NC_019751.1|WP_015198539.1|3485942_3488369_+|dynamin-like-GTPase-family-protein
MTKILPQCENLQSQVEAILELLQQESNLRSYDTTAVKTSLSKAIAPKFEIVFAGAFSAGKSMLINALLERELLYSAEGHATGTECKIEYAPLAEERVVLTFLSEVEIREQAIFLCQELGFDTVGNINQTEIIDLLTQGCQTIIQKEGGEGKSVRAKQAKALLLLLEGYVNNRGHIQTVTNATYSMEQFNFTNLKEAASYARRGINSAVLRRIEYYCYHPLLEDGNVIIDTPGIDAPVEKDAQLTYQKIQNPDTSAVVCVLKPAAAGDMTKEETQLLEMMRGNWGIRDRVFYIFNRIDETWYNTQLRQRLDDLISSQFRESSRVYKTSGLLGFYGSQLKQTSGRDRFGLDSVFAESVKGLDGVEETPQFVNEFLRYCANSGKLSPNQFRISVNSYETPNQNYTRILAEQGQPLIQKLIQDSGIEDFHTAITRYLTEEKRSQLFKTLADDLEDVCILLKKNYQQLQRDLDSQPREIEAMKTQELQRLNQQLQQLGKDFSQHITDEVNKIITNNCDAFETDFRHLQVKMIRRLDELLNTFSVADAYRRATLSHPRNATAPLLAILVEAFYYLANQLEDILVVSCEEIVASLFQRLLDGIHKADFYRQLYRLLGNDSSIEQKLKILEKDVLDGLVSNARVECDRFVRESPRFYDEGTFSIYQFRQTLIQTSQGYDCESMVEAEPAIRQLLKLDFEPKVNETIRKNFRQTVNQILKTQLLPMADQQADEILQQYAHARTYLEATLQQEAEDKISQNQQLLGTVEQKIAAYNSAINNINNCLRGMSLHEHLLPEIADSDVLTVEDKFLKTVVEV
>NC_019751.1|WP_051036677.1|3484671_3485625_+|hypothetical-protein
MGYLFDKWLAPLGDVKKDEIKETQGLQNHEIALLNLAPDYTGFICNFIPYLCNRETQNNSHQNGLRLVVELQTTPSIPKITDRELAAVKQVIEKRIQRLDISQATVQIQGKNQILIILPKVRDPSQVTRILGKSGKLEFKEQKSGTKNQLYTLLATRYQLTEKQQKLRKNSNPDQNAIAKNAQALQQNNLAISQVFKITKPPLTGKNITDAFSQSTQDKYRWEIAIRFDEEGSRTFAKVTKNLAGTGRAIGIFIDDKLVSSPVIGVEFAKSGITGGSAVISGSFTAEDAQDIALKLQSGAFPLPLKIIESTSIKQSK
>NC_019751.1|WP_015198537.1|3483636_3484536_+|hypothetical-protein
MLMTILRKFTAVFLAASLCLTTVACGGGNQTSSPTNSPAQNVSQKSVSTKLADGQYDVQQASFDDGNGEYMLMLLGATPPTFKTDKLQMARLTDEEIKAGKKTYLKVEGGQPALYLTEDFKIEYVHNVTETKTNPQTGQQETVVVRRENGFWAPFAGSVAGSIAGQAIGSLLFRPQYYVPPAYQPGGVIRGYGGYGSSYGDAVSSYRTRYNEAPAVERNRTAFRTTGSIRRNSPNTTNTRTTTKTTSGSRASGSGFGGSTLRPSGNSSTVRRSPSNNSFGSGRSAAPRRSSGSFGSRRR
>NC_019751.1|WP_015198536.1|3482973_3483567_+|DUF1517-domain-containing-protein
MRDGFNKMMGKTRYVVSRVFVHLGGADVAPILGILNSIARDAIDGDGDMETLGQGLVELCESLLQYDEYWVSAANEGDVFWNEGEAGDFVNELFTDSAQRYGAEFDIGYTNDSNQALSIPVTNNVLVMITAAAEGEVPELETDLSNISALKQGLKGLINLHYKHKLRAVQVHFSPAQFGEELTNDQLLQYYPELIPL
>NC_019751.1|WP_015198547.1|3493182_3494187_+|transaldolase
MSSNLLEQLRKMTVVVADTGDIQAIAQFKPQDATTNPSLITAAAQMPEYQEIVDQTLLKAKSDLGAGASQEDILTRAFDRLAVAFGLKILEIIPGRVSTEVDARLSYDTEGTIKKAHELIAQYEAAGIAKERILIKIASTWEGIRAAEVLEKEGIHCNLTLLFGIHQAIACAEAGITLISPFVGRILDWYKKDTGRDSYPAAEDPGVLSVTKIYNYYKKFGYKTEVMGASFRNIGEITELAGCDLLTISPQLLTELQGSTTELPRKLDPAKATAMTIEKIAVDKASYDKMHASDRMASEKLDEGIKGFTKALETLEQLLAERLKKLEEKAAVGV
>NC_019751.1|WP_015198548.1|3494598_3495363_+|CHAT-domain-containing-protein
MKKNILLLAANPKNTANLRLQEEEREIKERLRLNGYGKTPIFSTGATRIRDIQLAMLDFNPHIVHFCGHGTGERGLVFEDNNSREQIVTSEAIATIFKLFAQQEQLECVVLNACYSEEQAKEICKYVPYVVGMSESIGDDAAIEFAIGFYTTVGAGKSYQFAHEMGCNAIELADLTENNIPILLTNPDLIIKSQIPIATEEDLKYEAELKAIELQMLKNTQSYEREIRLLEYEQKKSKAYHRGFMSAFESKHDE
>NC_019751.1|WP_015198549.1|3495458_3496457_-|radical-SAM/Cys-rich-domain-protein
MQIQINNSQITSFSEKLKSPLLKQTISVLQVNLGKRCNLACNHCHVEASPKRTEELSPQICQQIIELIARFPQIQIIDLTGGAPEMNYGFNLLVEAANKYQKQVIVRSNLTIFFEPGFEYLPEYFAKNKIRVVASLPCYLADNVDKMRGIGVFNNSIRALQLLNQLGYASDENLILDLVYNPQLPKSENFALTPEQNKLEADYKHFLNTNFGINFNHLFTITNIPIGRTKLYLERQKLHTPYLKFLEKNFNPQTTEHLMCRNELSIDYLGNIYDCDFNQMMDLPARTSDGKTLTVAKLLEIGNLDLVSEVQTANYCYGCTAGSGSSCGGALV
>NC_019751.1|WP_015198550.1|3496493_3496817_-|hypothetical-protein
MNLNQINPNLINLVKVVSTTVMFSAVGLELGNIYALTNSIRVPSNLDIVFVVERIAVTSHFIEAIIAGFFAPAKNKQPIQYAVYTFFTGTIGLLELLQIDKVEEKPN
>NC_019751.1|WP_015198551.1|3496940_3497135_+|hypothetical-protein
MIAQDLDSKAVAEDISMKQIKIKQTQLKIARESNMTFVAEVLQHQLEELQDESNFQAMMSLLDD
>NC_019751.1|WP_015198552.1|3497243_3498638_-|histidine-kinase
MNGSLARDLSIYQQIVSAGTTSQAQAFSPATLLSMMRSHIDILIERKISATLWVKLPPGDVWQSELQRYQQQVYDCGKIYSFQIGEGIKIQTEDEINLSHPCHFPIYFPPKSRLRREYFLLILSPQFSSLIVAYRPLRSLKKTNPKKPNSGKIPVLVAINTFEGKIIKPVVDNIQAAFTQLEIFKLVLPETPEPSIISQLLLRQFYNQEKINRQITNIRLNKLRRQNQKMYQSLQLKDDYLSTVCQELRTPLTHMKTALSLLNSPVLKMPQRQRYLQMLSTECDRQNSLIMGITELVELERSLKSPTFEAVQLADIVPGVVSTYQPLAQERDIMLAYTVPQSLPNAWFISGGVKQIVINLLSNSIKFTPNGGEVWVKAKHQGDYIQMEIRDTGIGIAESEIPKIFNSFYHLRPANSDELAGVGLGLTIVQQMLQRCGGSISVKSKQNEGTTFTVQLAIAKQHRK
>NC_019751.1|WP_015198553.1|3498786_3500274_-|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase
MKLRELLAAVDGIVALPEHPAMDMEIEGLTTNSHATNVGELFVGMPGTRVDGGEFWQSALAAGAVAAIISTAAAAKVPPTADVCVITTSDMTKACAKISAAFYGYPGHALKLIGVTGTNGKTTTTHLIEFLLDKASLKTALMGTLYTRWQGFSQTAVHTTPFAVELQQQLAAAVDAGNEYGVMEISSHALAQGRVLGCKFEVGVFSNLTQDHLDYHKDMEDYFNAKALLFSPNYLQGRAIINIDDSYGQRLIQALGDEKVWSYSVNNTQANLWMSDLNYQQNGISGTLHTPKGNVKFHSPLVGQYNLENLLAAVGAVLHFDVDLDLVADAISEFPGVPGRMERVQLSENQDISVIVDYAHTPDSLENLLKASRPFIPGKIICVFGCGGDRDKTKRPKMGKIAAELADVAVVTSDNPRTEDAEQILKDILVGIPENTNPIVICDRAQAIRTAILSAKPGDGILLAGKGHEDYQILGTEKIHFDDREHAKDALKARV
>NC_019751.1|WP_015198554.1|3500400_3500676_-|glutaredoxin-family-protein
MRLILYSKPGCHLCEGLQQKLEQITTIQFELEIRDITTQDNWFAMYQYEIPVLMVQNYGNSDDTTTREQSIPRPSPRATVAQLEKLLQKYL
>NC_019751.1|WP_015198555.1|3501138_3502350_+|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MQKAFKIALIPSHNQEVLINKTIGCARFVYNRFLALRKELYATEQKTLNYNTCSQELTLLKKEIEWLKEVDKFALQNSLKNLEAAYKNFFTDLKKSKKKKGVGFPKFKKKYGCKQSYKTNLTNGNIQIIENRLKLPKLGWIKFYKSQDITGKLVNVTVTRTSSGKYIASILCETEIEKYPIGTQNIGLDLGIKSYLVTSEGEVIENPKYYRLQLKKLRKANKKLSRSTKGSSNRVKAKIKLARIYERITNLRDDFLHKLSTRLIKENSIICIEDLRVVNMVKNHKLALSISDASWSKFVTMLEYKALWHDRVVQKVGTFYPSSQTCNCCGLINPLVKDLKLREWSCPSCNSYNLRDKNASLNILSEGLRLLTAVGTPEVIKNACGELVSPELFQAEIVEAGIA
>NC_019751.1|WP_015198556.1|3502638_3505350_+|hypothetical-protein
MTQQHLLKLAMQGNTEAIETLINELLQPQGITAKVGSQQSSLYVALAAANVPKQQLLVPLIYQKILHWHVEYFQTAKIYAAAWGESSPAWQEEVLLSDAKSKNNDFVETNSDMLKDGGEKIDDSPDIKSMERTSGNLRIGDNVLQIGLPNGNVVKQGVSAPPCRWQPRPTPILSLPKTFPLLIGRLPQIKSAIAFSKEKHSVEFFGSPGLGKSSLLWHLGYYFQSQSRFSDGVVGFNTHYESVSDILQGLFDIFYESEKGCKPTLSEIQQALRNKQILVFLDDQNLSSDEVGDLIKTLPNITFIIASTEQRLSQTGQSLRLPGLTNRDGLTLVSHELKRSLTPEERTAFDALYLRFEGHPWLLQLTAIAMRQGVGTLAEILIKLQLADSNNWLVKQILASLSSPQLAVVAALASVGGAGLLIPQIAALSGVRETADVLASLAELKLVQAENDTFTGNGYYRYSVTSSLIDALPPEWDLETLRLRSFNYFIGWAQKSRNINSINTINTINNLLFSETDAIMTTLAWGVKSQQWAQVLSMVQTVETPIALARRWGLWEQLLKWGLQASEKLSDDATTAYILHQLGTRSFCLNDYTSAQEYLNRSLKIRQSLADTQGMEITSYTLGLIPKPETSAVVTPPKNSIPQTFKLQTSKLIYPKIRISSATLIPLTMVGAVGLTGYYLILQPKSSTTSQIPVKSTSPIPPTSKSVAVKPVSFSREKFNFGNQSIDIKNQQLFLTIINPNTTSLEVGKIKPIGKQADFEVNLDDCSNPITSNEICKLAIIFNPLTTGKHQATLPVTDSQGKIIKQIPIEGVATAPTLPFIPETNLPAPTSEVEEVLPTPKAKEFPRIRRTKIQPQVIPRESTSTTPESSPQVTPTESPTPLPTETPGLQPTPETTPEVMDTP

Crispr_ID: NC_019751_16

• CRISPR_ID: NC_019751_16
• CRISPR_location: 3544526-3544629
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_16

Consensus_repeat	Method
AAGCAATCTCGAAATCTTCTTTTCAC	CRISPRCasFinder

spacers of NC_019751_16

>16.1|3544552|52|NC_019751|CRISPRCasFinder
CAATAACCCAGTTACCTAGGTGAAAGATGAAAATTGTCATTGCGACGCAAGG

CRISPR arrays and Neighbor proteins around NC_019751_16

CRISPR arrays

The CRISPR arrays of NC_019751_16

>merge|NC_019751|16|3544526-3544629|CRISPRCasFinder
AAGCAATCTCGAAATCTTCTTTTCACCAATAACCCAGTTACCTAGGTGAAAGATGAAAATTGTCATTGCGACGCAAGGAAGCAATCTCAAAATCTTCTTTTCAC

>NC_019751|16|15|3544526-3544629|CRISPRCasFinder
AAGCAATCTCGAAATCTTCTTTTCAC	CAATAACCCAGTTACCTAGGTGAAAGATGAAAATTGTCATTGCGACGCAAGG
AAGCAATCTCAAAATCTTCTTTTCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015198594.1|3557246_3558380_-|S-layer-family-protein	unknown	unknown	gnl|CDD|225751
NC_019751.1|WP_015198582.1|3540429_3541212_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224052
NC_019751.1|WP_015198005.1|3558411_3559752_+|IS4-family-transposase	unknown	unknown	gnl|CDD|379252
NC_019751.1|WP_015198589.1|3549917_3551606_+|dihydroxy-acid-dehydratase	unknown	unknown	gnl|CDD|234861
NC_019751.1|WP_015198576.1|3533948_3535142_+|DUF262-domain-containing-protein	unknown	unknown	gnl|CDD|377008
NC_019751.1|WP_015198584.1|3541951_3543457_+|NAD(P)-binding-protein	unknown	unknown	gnl|CDD|131777
NC_019751.1|WP_015198591.1|3554042_3555545_+|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl|CDD|180945
NC_019751.1|WP_015198590.1|3552033_3553896_+|NAD(P)H-quinone-oxidoreductase-subunit-F	unknown	unknown	gnl|CDD|236008
NC_019751.1|WP_015198583.1|3541330_3541555_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_041740600.1|3548926_3549337_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198578.1|3536390_3536861_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379228
NC_019751.1|WP_015198585.1|3543548_3544451_-|trypsin-like-serine-protease	unknown	unknown	gnl|CDD|226119
NC_019751.1|WP_015198588.1|3549336_3549633_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198581.1|3538910_3540356_-|MCE-family-protein	unknown	unknown	gnl|CDD|178642
NC_019751.1|WP_015198595.1|3559729_3561943_-|filamentous-hemagglutinin-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|368641
NC_019751.1|WP_015198579.1|3536808_3537741_-|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_019751.1|WP_015198586.1|3544718_3548399_-|DUF2225-domain-containing-protein	unknown	unknown	gnl|CDD|378942
NC_019751.1|WP_015198580.1|3538020_3538611_-|L-threonylcarbamoyladenylate-synthase	unknown	unknown	gnl|CDD|223088
NC_019751.1|WP_015198592.1|3555665_3556979_+|CO2-hydration-protein	unknown	unknown	gnl|CDD|370890
NC_019751.1|WP_015198577.1|3535157_3536225_+|hypothetical-protein	unknown	unknown	gnl|CDD|376158

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015198594.1|3557246_3558380_-|S-layer-family-protein	gnl|CDD|225751	COG3210, FhaB, Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion].	1.31739e-14
NC_019751.1|WP_015198582.1|3540429_3541212_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224052	COG1127, Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism].	4.13292e-120
NC_019751.1|WP_015198005.1|3558411_3559752_+|IS4-family-transposase	gnl|CDD|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	2.62831e-61
NC_019751.1|WP_015198589.1|3549917_3551606_+|dihydroxy-acid-dehydratase	gnl|CDD|234861	PRK00911, PRK00911, dihydroxy-acid dehydratase; Provisional.	0
NC_019751.1|WP_015198576.1|3533948_3535142_+|DUF262-domain-containing-protein	gnl|CDD|377008	pfam03235, DUF262, Protein of unknown function DUF262.	6.29785e-27
NC_019751.1|WP_015198584.1|3541951_3543457_+|NAD(P)-binding-protein	gnl|CDD|131777	TIGR02730, Carotenoid_isomerase, carotene isomerase. Members of this family, including sll0033 (crtH) of Synechocystis sp. PCC 6803, catalyze a cis-trans isomerization of carotenes to the all-trans lycopene, a reaction that can also occur non-enzymatically in light through photoisomerization. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.45282e-101
NC_019751.1|WP_015198590.1|3552033_3553896_+|NAD(P)H-quinone-oxidoreductase-subunit-F	gnl|CDD|236008	PRK07390, PRK07390, NAD(P)H-quinone oxidoreductase subunit F; Validated.	0
NC_019751.1|WP_015198578.1|3536390_3536861_+|GNAT-family-N-acetyltransferase	gnl|CDD|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.43957e-17
NC_019751.1|WP_015198585.1|3543548_3544451_-|trypsin-like-serine-protease	gnl|CDD|226119	COG3591, COG3591, V8-like Glu-specific endopeptidase [Amino acid transport and metabolism].	7.78859e-09
NC_019751.1|WP_015198591.1|3554042_3555545_+|NADH-quinone-oxidoreductase-subunit-M	gnl|CDD|180945	PRK07363, PRK07363, NADH-quinone oxidoreductase subunit M.	0
NC_019751.1|WP_015198581.1|3538910_3540356_-|MCE-family-protein	gnl|CDD|178642	PLN03094, PLN03094, Substrate binding subunit of ER-derived-lipid transporter; Provisional.	1.71264e-34
NC_019751.1|WP_015198595.1|3559729_3561943_-|filamentous-hemagglutinin-N-terminal-domain-containing-protein	gnl|CDD|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	6.70233e-22
NC_019751.1|WP_015198579.1|3536808_3537741_-|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.29442e-14
NC_019751.1|WP_015198586.1|3544718_3548399_-|DUF2225-domain-containing-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	1.7875e-63
NC_019751.1|WP_015198580.1|3538020_3538611_-|L-threonylcarbamoyladenylate-synthase	gnl|CDD|223088	COG0009, SUA5, Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis].	6.76386e-55
NC_019751.1|WP_015198592.1|3555665_3556979_+|CO2-hydration-protein	gnl|CDD|370890	pfam10216, ChpXY, CO2 hydration protein (ChpXY). This small family of proteins includes paralogues ChpX and ChpY in Synechococcus sp. PCC7942 and other cyanobacteria, associated with distinct NAD(P)H dehydrogenase complexes. These proteins collectively enable light-dependent CO2 hydration and CO2 uptake; loss of both blocks growth at low CO2 concentrations.	0
NC_019751.1|WP_015198577.1|3535157_3536225_+|hypothetical-protein	gnl|CDD|376158	pfam18735, HEPN_RiboL-PSP, RiboL-PSP-HEPN. RiboL-PSP-HEPN. Fused to endoRNase L-PSP ; in operon with ParB.	9.64008e-12

Protein sequences

>NC_019751.1|WP_015198585.1|3543548_3544451_-|trypsin-like-serine-protease
MNKQSFALLFTGIIGAATLTLSVQAQTKQSITPKFISAKTGGFKFDANVKPFIPDGLGRSAKPDEGDSRGIVSDIDNRIPMLSKKYPWSAIGRVKGTTTNAESYHCTGTLIGEDLVLTNAHCVIDPETKEKSAKIQFMPNVIDGKYQDVAEVVDVIYGTDFKQGDQISPNDWAIMTINKPLGRKYGFLGMKPIPTSTLINNPRSLFFVGYSKDFPTENYQKYLTAGKGWTASYEKGCSITKEEAGFLFHDCATAGGSSGGALIGIIGGEPYILALNNAELGNITNFAVKISTIQEDLSQK
>NC_019751.1|WP_015198584.1|3541951_3543457_+|NAD(P)-binding-protein
MFDVIVIGSGIGGLTAAGLLARYGKRVVVYESHTVFGGAAHSFKRQGFEFDSGPSFYCGLTGAESLNPVKQVLDILGESLQTVTYDPLGHYHFPEGSFPVYSNLQRYQDEVAKITPQGSAELQRFYQRMLPLYAAMKEIPTVTLRSDWQLIPVLLGNYGLSLLKMLPHLPILQGSVGDVMDSTIKDSWVRRLIDLECFLLSGLKANGTVAPEVAFMLGERSRAGVEYPIGGTGAIIDAFVRGIERFGGVMRSRSHVNQVLISNNSVTGVQLQNGEVISAPVVISNATLWDTYTELLQPNDLPETYRRDALDTGYVDSFMHLHLGIRSDGLENLTGHHVVVQDSHEDITVPGNTCMISIPSVWDANLAPAGHHVVHAYTLEPYAGWQRDDGYEQKKRQKADVLYQALAKVIPDIRERVTLELIGTPLTHAHYLRRYKGTYGAAIPANQGMFPSTHTPISGLYRVGDSTIPGIGVPAVAASGILCANTLVSPQVVKEICSKLN
>NC_019751.1|WP_015198583.1|3541330_3541555_-|hypothetical-protein
MNNIRNSDFDNHAEDALLPEYDFDYTQVRPNRFANQQNKTQINIALDPDVAEIFTTSEAVNNALRAILSAIPKQ
>NC_019751.1|WP_015198582.1|3540429_3541212_-|ATP-binding-cassette-domain-containing-protein
MTEPLIELKGISKTFGNNKVLDNVDLTINRGEALGIIGPSGTGKSTILRIIAGLTPPDTGEIHVQGVKRRGLIEDSADPVGISMVFQQAALFDSLTVEENVGFLLYQHSKLGRRRIRDLVNEKLEMVGLGGISDRYPSELSGGMRKRVSFARAIISNPEHPEDAPEVLLYDEPTAGLDPIASTVIEDLIRQLQASQGVCSTYAIVTHQDSTIRRTSDRIIFLYQGKVQWQGHVNEVDRTENPLIRQFMSGSIAGPIQVGG
>NC_019751.1|WP_015198581.1|3538910_3540356_-|MCE-family-protein
MRSLRTIREGSVGLLVLAGLGIFGLIFLWLNRFTASQNSYKAIVEFKDAGGLQKGAVVRYRGVKVGRTISVKPGLNAVEVEIEINQPELIIPSNVTVEASQSGLISEGIVDIIPRLKIPEGAIAGKPLEATCDSNQIICNNSRLKGQIGISIDQVLRSTNDLAVVYSNPKFYANLNQALEQSTLAASGVATLSKNLSSLSLSAKNQLSDFSGVGNSVQRAVNQASSSTTQLSANANQTLDKFAATAGEFGITAKELRTTNSQAGKLLANLDNLVVNNRSSLVSTLNNLSVSSSQLRTTVSSLSPTVNRLTQGELIKNFEILSANAAEASTNLRDATKTLNDPKNAILLQQTLDSARVTFENTQKLTSDLDELTGDPKFRTNLRQLVNGLSNLVSSTQEIEQQVQVAQTLDSMKAGTFSKNTPVVNFDSELSQIPPTSASTKRNQAIKRLTKILQQNNQAAKASLDKSRDVSNQESKAINSP
>NC_019751.1|WP_015198580.1|3538020_3538611_-|L-threonylcarbamoyladenylate-synthase
MDHVSLINLVSNARQGKLVSFPTDTVPALATVPEFAELIFTAKQRSQDKPLILMAATTEELWNYVVGSPEECQEWQSMMDKYLPGALTLVLPASKNVPKNLNPQQPNTIGVRIPKSAIAQTILSQTGALATTSANLSGQPALLTMEEIAVQFPDVATLDPREFASEELNTKGVPSTVIKWTGKDWQILRQGAVILE
>NC_019751.1|WP_015198579.1|3536808_3537741_-|HAMP-domain-containing-histidine-kinase
MNWSNWIYLAVGVGLGAALRSLFTRPQASVSAFAPLTPVSEAEDKPPLSKPIEQTQLAYQMAREMEQFKAGFLARVTHELRSPLNGLIGLHQLILSDLCENPEEEREFIGQAHERALQLLKIIDEVLNVARTEYGSNRLDMRSHSVAEVLKEVHTLTHMLAKNRNYPFQVTFPDVSLTVTTDHRWLRQIILSLVETSIACIDAEVQEGSIYLSAASCPTGVTQIWLDIPIYALPKSEAIDLLTLTNQPSNTTMTVGMKLLLNQTLVEAIGGKMEILPHPEKEASNQDLIRLQISISPGIPEAELQLQEAS
>NC_019751.1|WP_015198578.1|3536390_3536861_+|GNAT-family-N-acetyltransferase
MDNTQIQFSDRKSEINLEQLQQLFTLSAFWAKERNLEDLEIAIANSEPVITVWNREKLIGFARATSDGIYRATIWDVAIHPDYQKQGLGSKLVETVLSHPRMCRVERVYLMTTHQQRFYERIGFQTNSTTTMVLYNQEPTSLLPEAEVLLQESLGK
>NC_019751.1|WP_015198577.1|3535157_3536225_+|hypothetical-protein
MNTTSLDSFKKEINQVREYIKHIQDVDNIVNYTVSEADNEEIKALLNTLKEHHRIFRTDKKIFEYKASIISLYGLLEKYVENWIKEYLTALSGLVLEYDKIHEKIRNNHFELSVKLISSIVSREIAKYQHLTKEQVLKELNECIVNTANYKFNTEAFVLSSGNLKHKQIVKLFELINVSLNEVLKKNETLIQYFKDDRGITNISNTNTDILYNTINDLVERRNQIAHGSEILDILNISELESYIQFLEKYCQAVFEILAEEFIKQESIYTFQKIEKVIKIFGNRILAFEIENYKIKIGDILIIETIEGKFYKKPILTIELNNESHAEIIIMEKQNIAVSVEPSIKENQTFYIVKQ
>NC_019751.1|WP_015198576.1|3533948_3535142_+|DUF262-domain-containing-protein
MTTKNHLIPGETFFYSDKSDISQVSLSDDEINEKYKKGEIRIVTEQARYPLDSIETMLDSQKYILNPEYQRRKRWNNTRKSRLMESFIMNVPIPPIFLYEVSYSIYEVMDGLQRLTAIYDFYKGKYNLEGLEYWRELNGRNYQNLPEQIKRGIDRRYLSSIVLLQETAKSAEEADFLKQIVFERLNSGGEQLTAQETRNALHNGKFNQLCIKLAENDFFRKMWKLPLESEGEEKLLESEPYRKMEDVELVLRFFAYRHIANFKSPLDKFLDDYLKHANAYSDETINNLENLFNETINLVYSIFGDSAFIPPKEKRDNKTPIRIVYDSMMQVFANNIPHKEILLNHSKSIKSALYSDKQLLHLKEEKNRLLFDARYNNKKDVEARIKYFQNFLQSYIP
>NC_019751.1|WP_015198586.1|3544718_3548399_-|DUF2225-domain-containing-protein
MAQCKKNRVNLSYFLAKFTRYSLIGLLSVVLVSESVGASVTLAQSQIAQQTVPNPSVPLSGEKQKRYQEQVKLYQEGEELQKKGTREGYLQAIEKYQQALKIAQKIGLRGEEAEILMQIGLVNVFLSEYQQALDLYNQSLKIWQELNQPLFEAIVLSMIGDTYNNMGKTQESLDYLKRAESSFRTQKQFRYLAINLSSISRVYMRLGQTKNALHFLNQALEIYRTTYKDQVKEAHTLNSLAFINSLIGQSEVAFKYYNQAVEIYRERKDFLGQAEMLKSIGSLHGKLGKHDLALEYLNKALEIQSTKGTLVDRGLTINDIASIYSSRGDYEKAVEYYQKAKLLFHEAGWTTLETLSIGSIVSIYRNFLGNNQQALKYTEEVLKLNRKTGEKDEEASTLNQKGDIYIQQGDYQLALDAYNQALEIERSITKNPKAAARTLGNIALLYNSLGDSKLSIRTYNQALDIYRKLDNKAQQARILLYMGGVYQKNEKLDDALVSYNQAIKLLNEENYNLEISIHYGLARIYRDKEDYTKAFKSANLALELSKKHENSFQEIASLGIIGSIYLAQGDYTNALDSYNEVLDRCRKSDLKIKEAETLSTISIAYGFQQQHQKAINTLNEELKLRQTLKDKIGEAQVNYQIAINQRKLGKLETALTNIDEAIKIVESIRSNVKNPDLRTSYFATVQNYYKFKIDLLMELHKKQPSKGYDALALNTSEASRARGLVDLLTEAGANIRKGANPQLLAEEQRLQQLLNGKEKARIDILSTSKGNDVAKTTADKLGDEIADIINQQQQLKTQILTKSPEYAALKYPQPLELKGIQQQLDKDTILLQYSLGKERSYLWLVTPDSVQAYELAKGEVIEKAVENFRDVILTANTPYGKDHPDDINQPASQLSQMILAPVANKLGKKRLVIVADGALQNIPFAALADPGTPPPTPRLQGGEESKPLSLQERGLERGSYQPLLVNHEIVNLPSITAIQTQRKHLNNRLLSPKTLAVLADPFFTTEQAQGKLEALGPEISDNPQEVIKNSEKLPPLPGTRIEAEAMLKSLSSDQKTHAFGADANYNFATNPTLKQYRHLFFATHGFVNTERPELSGIALAQVDKDGKPVDEKKGYLRLGDIFNMDWAAELVVLSACETGLGKDTKGEGLVGLTRGLMYAGSKRAVVSLWKVSDKGTSELMPIFYKSVLAGKSPAVALREAQLQMWQGKEWRNPYYWAAFTLQGEWR
>NC_019751.1|WP_041740600.1|3548926_3549337_+|hypothetical-protein
MTEETRGEIARRLAIELSLRTEIYQKREGQGFKTFGEFKRTIGVAGAGQAWHHIVGQTTANLQKFGAEAIHNTGNLIRIEHGKGSIHQEITNFYNSVQPEITGSSNITVREWLGNQSFEEQQDFGIRVIKIFGGSL
>NC_019751.1|WP_015198588.1|3549336_3549633_+|hypothetical-protein
MLTIDLQSILNSIPNEVNWQNIVEFEKLDERVSIANEVCANLVGVNDGFIEWCPNEEPASHLETLLWWWVVRPDLGAAIAREAPQELKEIISQYILNN
>NC_019751.1|WP_015198589.1|3549917_3551606_+|dihydroxy-acid-dehydratase
MPENLKSQVVTQGVQRSPNRAMLRAVGFGDEDFNKAIVGIANSYSTITPCNMGINQLAQRAEIGVRAAGAMPQMFGTITISDGISMGTEGMKYSLVSREVIADSIETACTGQSMDGVLAIGGCDKNMPGAMIAIARMNIPAIFVYGGTIKPGHYDGKDLTVVSSFEAVGQYSAGKIDDAELTEVERNACPGAGSCGGMFTANTMSSAFEAMGMSLPYSSTMAAEDAEKADSTEESGRVLVEAIRKQILPRQIITRKSIENALAVIMAVGGSTNAVLHFLAIAHTAGVKLVLDDIETIRARVPVLCDLKPSGKYVATDLHKAGGIPQVMKMLLAHGLIHGDCLTITGQTIAESLADIPETPSPNQDVIRPWENPMYKEGHLAILKGNLASEGSVAKITGVKVPKISGPARVFESEEDCLAAILAKKINPGDILIIRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGMVVGHVAPEAAVGGNIALVEEGDTITIDAHSRSLNLHVDDAELSRRRANWQPKPPRYTTGILGKYAKLVSSSSLGAVTDLDLFS
>NC_019751.1|WP_015198590.1|3552033_3553896_+|NAD(P)H-quinone-oxidoreductase-subunit-F
MTNFLLETVWLVPCYALIGGLLALPWSPGIIKRTGPRPAGYINLVLTFLAFVHSACVLPITWNHLPHEISIPWLNIAGLNLSIDLEISSLSVGAMVVITGLNLLAQIFAIGYMEMDWGWARFYSLLGLFEAGLCSLTLCNSLFFSYVVLEVLTLGTYLLVGLWFSQPLVVTGARDAFLTKRVGDLFLLMGVLALWSQAGTWNYTDLAEWATTANVNPTLITLTCLALIAGPMGKCAQFPLHLWLDEAMEGPVPSTILRNSVVVASGAWVLIKLQPVFSLSPMASSAMVAIGVVTAVGGSLIAIAQIDIKRCLSYSVSAYMGLVFIAVGTQQDEAALLLVLTHALGSALLVMSTGAIVWNSITQDVSLLGGLWSRRPVSGIAYIVGTLGLIGVPPLGGFWALLQLASGLWTTQPWLVGVIIVVNALTAFSLTREFSLIFGGQSKQMSDRSPEVSWQMALPMMILLGFTLHLPLVLQSLSLLPTWATVNKDVALLLIWSSIFGCSISSVIYLGNVIPKPIRFPSKPIQNLLAYDFYTPKLYKMSIVLGVDMISKLTDMIDRFIIDGIVNLVGLVSILSGESLKYSTSGRTQFYTFTLLIGVSVLGMLVTWQYWGDNLFNLIF
>NC_019751.1|WP_015198591.1|3554042_3555545_+|NADH-quinone-oxidoreductase-subunit-M
MLSTLIWLPIIGAAIISLLPRAIPAINIRLTAITIAGLVLAWNIYLLFQFDISLPGMQLQESLPWNDTLGLNYKLGVDGLSILMLFLNSLLTWIAIYSSNQQTERPRLFYSLILLVSGGVAGAFVAQNLLLFFLFYELELIPFYLLISIWGGEKRSYAAMKFLIYTAVSGALILATFLGTVWLTGATDFDYNTISTQALSTTLQIVLLVGIILGFGIKIPLVPLHTWLPDAYVEASAPVAILLGGVLAKLGTYGLLRFGMAMFPDAWSILAPSLATWGAISAIYGAVTAIAQKDIKRMVAYSSIGHMGYILLAAAASTSLALIGAIAQMFSHGIILAILFHLVGVIEAKVGTRELDKLNGLMSPIRGLPLTSALLILGGMASTGIPGMTGFIAEFIVFQGSFSVFPIPTLLCVVASGLTAVYFVILLNRTCFGKLDNKLAYYPKVLLSEQIPALILAIMIVFLGVQPGFLVRWSEPTTTAIVAAIPPMEKTITAQVALNN
>NC_019751.1|WP_015198592.1|3555665_3556979_+|CO2-hydration-protein
MVQTPNKTEAKLPPSTHEFAEVIHRLEAGGAMLPDTPENLMQIIGLYKAYAVPMDFYWRDLLYIAERVFLNPFAFFKYFISPEYLERHNHYAGDDADLRVWRGEATAHPELLEFMEKGETFKMPKILHHLFHDRINMEFAEACMRAMLWHRGMGGKFDPYLDTEEYKANADRAIKAYFQGNPFMLGLYKLFPDMFLEQCRQMSYYSNLGLFWEVMAPVFFEMSDLYDEGKITSVPEAMNFLVNGIFAVANRPIYHHVYIRGECYEIIPKSKGFVWLHEAALPYVEAVFYRTAPFRGTKSYNAQAGQVPTDQKDFHYGILYADVFPVGTAGIPPTLLMQDMLHFLPPYLIDYYKQYCRGEEDTLIQLGISFQRSMYCVTSAVIQALRTVLCHPLDDPDPEHLQANRDFFESQLNRFTRPEYGIRDAARLNDIQRQDYR
>NC_019751.1|WP_015198594.1|3557246_3558380_-|S-layer-family-protein
MRDNNSTTKRPTSSSSSSYFGEGIVNTQDLIVRDGAVVSAETFAVGKGGNLTVNASKNIELVGTSVDGSVFSGLISAANQGSSGNAGDLTIKTQNLLVRDRAGVFVNSLGTGNAGILTINSDRIRLDNKASLNANTRSPNKDTNREQATINLNTDALILRRNSNITTNAQGQNVIGGNINIDAGVIAAFENSDINANSTDFRGGRVKINAEGIFGTQARNSPTPESDITATGANPSLNGTTEINLPDVDPSKGLIELPEGLKDQSDQIDQLCGRGKKPLGRFVVTGKDGSIPSNPVVNTMSGYLDLTTIASFGEVNSNVPVNPIPDSLMAQKPPENRIVEAQAIVRGADGDLYLVAEAPSVIPNSRPAVSACVGLRR
>NC_019751.1|WP_015198005.1|3558411_3559752_+|IS4-family-transposase
MFDILSLLQCFLPQINATTMKQLNQIILAMLAMSGRVTMLGISRWTGSGGSYRTMLRFFHTVIPWATLFWLFFRKHLFRANEVYLLAGDEVVVSKSGKKTYGLDRFFSSLVSKPISGLSFFTLSLVSVEQRHSFPIQIEQVIKNDIEKSSVSPRPEIKAKEKRGRGRPKGSKNKNKTEVILTSELLRIKKMINELVKLVANFIPLTYLVLDGHFGNNNALQMARQVNLHIISKLRHDSALYIPYQNPDPNHRSRRKYGDKLDWRNISDEYLRQSSIEEDIQTDSYQATLLHKEFAQSLNVVILVKTNLKTNARSHVILFSSDLKLSSEKIIDYYKLRFQIEFNFRDAKQFWGLEDFMNIGQTAVTNAANLAFFMVNLSHHLLADFRILNPDSGIIDLKAHYRGFRYVHEILKMLPEIPEPILLTRIFAKLTSLGRIHHVSTGVESS
>NC_019751.1|WP_015198595.1|3559729_3561943_-|filamentous-hemagglutinin-N-terminal-domain-containing-protein
MNKIKLLFASLFLYNFALIKNLPTQAQIIPDSTLANESSQINSNVLIKGSNAEQINGGATRGSNLFHSFSEFNIKDGQRVYFANPSGVFNILTRVTGGNASSIFGTLGVDGSANLFLMNPNGILFGQNASLDIRGSFVGTTANGLQFGNQGVFSATNPEAPGLLTINPSVLWFNQLNQNATIKNNALTTGLVVDEGKSLLLVGGNISIDGGILFAPGGRVELGGLAEPGSVGIQQDGNILSLNFPVQVERADVLLNNRAGVSVISGGGGSVTINARNIDILEGSLILAGIGRGLGTDDSKAGDITLNATREIKVEQGSYIRNAVSSNATGNGGNLTINAQNLFVQSGGRIQVSTLGKGKGGNLTVNVSDKIELVGTSDDGLIPSGLFALTLKPSTRNAGNITINTQDLFVRDGAQLSAATFGAGKGGDLTVNASRQVELVGTSKNVSLISGLFASAQSGSIGDAGDLTINTQNLFIRDGAQVNTGTFGAGKAGNLTVNASEKVELVGQEGVRNLLTGLSSSSELGSTGDAGDLTINTQNVFVQDRAQIATSTSGSGKGGNLIVNASKRVQLGGIVTASAEPFSTGNAGNLTINTPDLLVRDGGRVLAATAGTGKGGNLSVNASGSVQVIGTSADGLLSSGLGTSAESDATGNAGDLTINTPDLLVRDGAQVGVGTFGAGDGGKLTVNASNRVQIIGESADGLLTSGLYASAQRNSTGNAGNLTINQYLCQIKRIQRP

Crispr_ID: NC_019751_17

• CRISPR_ID: NC_019751_17
• CRISPR_location: 3976837-3976932
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_17

Consensus_repeat	Method
GAAATCAGTAAACTTCCTCAACAA	CRISPRCasFinder

spacers of NC_019751_17

>17.1|3976861|48|NC_019751|CRISPRCasFinder
GTATCCCAAGTTGTGGAAACCTCAGATAGTTCAGATGGAGTTGTACTT

CRISPR arrays and Neighbor proteins around NC_019751_17

CRISPR arrays

The CRISPR arrays of NC_019751_17

>merge|NC_019751|17|3976837-3976932|CRISPRCasFinder
GAAATCAGTAAACTTCCTCAACAAGTATCCCAAGTTGTGGAAACCTCAGATAGTTCAGATGGAGTTGTACTTGAAATCAGTAAACTTCCTCAAAAA

>NC_019751|17|16|3976837-3976932|CRISPRCasFinder
GAAATCAGTAAACTTCCTCAACAA	GTATCCCAAGTTGTGGAAACCTCAGATAGTTCAGATGGAGTTGTACTT
GAAATCAGTAAACTTCCTCAAAAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_041739691.1|3984786_3985125_-|hypothetical-protein	unknown	unknown	gnl|CDD|274465
NC_019751.1|WP_015198914.1|3966383_3968354_-|acetate--CoA-ligase	unknown	unknown	gnl|CDD|234677
NC_019751.1|WP_083866321.1|3973036_3973318_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl|CDD|368240
NC_019751.1|WP_015198921.1|3974065_3974251_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198918.1|3972205_3972523_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198922.1|3974278_3976543_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198924.1|3978820_3979015_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_041740688.1|3970238_3970679_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015198927.1|3980043_3980994_-|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223633
NC_019751.1|WP_015198931.1|3987351_3987948_-|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl|CDD|178955
NC_019751.1|WP_083866374.1|3976974_3978483_+|iron-uptake-porin	unknown	unknown	gnl|CDD|335962
NC_019751.1|WP_015198920.1|3973364_3973652_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl|CDD|376852
NC_019751.1|WP_015198928.1|3981355_3982537_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380571
NC_019751.1|WP_051036686.1|3982797_3983505_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274465
NC_019751.1|WP_015198930.1|3986142_3986790_-|J-domain-containing-protein	unknown	unknown	gnl|CDD|365959
NC_019751.1|WP_015198929.1|3985249_3985861_+|pentapeptide-repeat-containing-protein	unknown	unknown	gnl|CDD|224276
NC_019751.1|WP_015198917.1|3970777_3971869_-|threonine-synthase	unknown	unknown	gnl|CDD|236013
NC_019751.1|WP_015198925.1|3979411_3979777_+|DUF2237-domain-containing-protein	unknown	unknown	gnl|CDD|378344
NC_019751.1|WP_015198919.1|3972519_3972882_+|hypothetical-protein	unknown	unknown	gnl|CDD|227837
NC_019751.1|WP_015198915.1|3969169_3969865_-|sugar-transferase	unknown	unknown	gnl|CDD|376775

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_041739691.1|3984786_3985125_-|hypothetical-protein	gnl|CDD|274465	TIGR03169, selenide_water_dikinase_putative, pyridine nucleotide-disulfide oxidoreductase family protein. Members of this protein family include N-terminal sequence regions of (probable) bifunctional proteins whose C-terminal sequences are SelD, or selenide,water dikinase, the selenium donor protein necessary for selenium incorporation into protein (as selenocysteine), tRNA (as 2-selenouridine), or both. However, some members of this family occur in species that do not show selenium incorporation, and the function of this protein family is unknown.	1.86849e-52
NC_019751.1|WP_015198914.1|3966383_3968354_-|acetate--CoA-ligase	gnl|CDD|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NC_019751.1|WP_015198915.1|3969169_3969865_-|sugar-transferase	gnl|CDD|376775	pfam02397, Bac_transf, Bacterial sugar transferase. This Pfam family represents a conserved region from a number of different bacterial sugar transferases, involved in diverse biosynthesis pathways.	2.32156e-94
NC_019751.1|WP_083866321.1|3973036_3973318_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl|CDD|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	0.000743448
NC_019751.1|WP_015198929.1|3985249_3985861_+|pentapeptide-repeat-containing-protein	gnl|CDD|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	1.13528e-18
NC_019751.1|WP_015198927.1|3980043_3980994_-|branched-chain-amino-acid-ABC-transporter-permease	gnl|CDD|223633	COG0559, LivH, Branched-chain amino acid ABC-type transport system, permease components [Amino acid transport and metabolism].	8.18567e-72
NC_019751.1|WP_015198931.1|3987351_3987948_-|ATP-dependent-Clp-protease-proteolytic-subunit	gnl|CDD|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	2.19739e-129
NC_019751.1|WP_083866374.1|3976974_3978483_+|iron-uptake-porin	gnl|CDD|335962	pfam04966, OprB, Carbohydrate-selective porin, OprB family.	1.96111e-15
NC_019751.1|WP_015198920.1|3973364_3973652_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl|CDD|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	6.87147e-08
NC_019751.1|WP_015198928.1|3981355_3982537_-|ABC-transporter-substrate-binding-protein	gnl|CDD|380571	cd06348, PBP1_ABC_HAAT-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.	2.46099e-139
NC_019751.1|WP_015198930.1|3986142_3986790_-|J-domain-containing-protein	gnl|CDD|365959	pfam00226, DnaJ, DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.	7.48636e-17
NC_019751.1|WP_015198917.1|3970777_3971869_-|threonine-synthase	gnl|CDD|236013	PRK07409, PRK07409, threonine synthase; Validated.	0
NC_019751.1|WP_015198925.1|3979411_3979777_+|DUF2237-domain-containing-protein	gnl|CDD|378344	pfam09996, DUF2237, Uncharacterized protein conserved in bacteria (DUF2237). This domain, found in various hypothetical bacterial proteins, has no known function.	8.00202e-75
NC_019751.1|WP_015198919.1|3972519_3972882_+|hypothetical-protein	gnl|CDD|227837	COG5550, COG5550, Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones].	4.21987e-17
NC_019751.1|WP_051036686.1|3982797_3983505_-|FAD-dependent-oxidoreductase	gnl|CDD|274465	TIGR03169, selenide_water_dikinase_putative, pyridine nucleotide-disulfide oxidoreductase family protein. Members of this protein family include N-terminal sequence regions of (probable) bifunctional proteins whose C-terminal sequences are SelD, or selenide,water dikinase, the selenium donor protein necessary for selenium incorporation into protein (as selenocysteine), tRNA (as 2-selenouridine), or both. However, some members of this family occur in species that do not show selenium incorporation, and the function of this protein family is unknown.	7.05378e-96

Protein sequences

>NC_019751.1|WP_015198922.1|3974278_3976543_-|hypothetical-protein
MANPPHQPNPNARIIKRVIKKTGKKYQRQNSLVSWLAIAFLLGTGSLVVGFAWISFLYIFNPQKVSWLNKVLPTWARISMQGENPLSLKQIQTAITKQGLIPGETLTLKNKGFLLPVYKKRANCQDDCQEIIELRLYQQGIDGDSQVTRKYQLISQTTVTGPEESFVAAPLSNAINESPGTSVALPLTEIGQMEAAPSPGMWFYLRGQRQDSAYTAAYGHIIYYNPERDRIQQMLSWTSPTGQLPQWQKQGLVINQTVGLEPQLLVYQVKSVKLFLNPVELVEITLKPAAWKNDNYEKALSLARSGLWTPAYTWLQSIQKQNKNIPVSAQAQIEVIRLHSQLTQAQAAKSWASPSQEILANLIDGRWSQALEVFKQGSPEKAQEIAAFLKTDDGRLWNRLEAALEVNQNRPEVQLWGGLIVAAREGNAKATSWLQKRKATSQTLSDSKVLFAKLRGEVVTKSPVIPNHPSRIIGSVQAITKVNPSEWLQPEEKLDVVTHQKWYQVEVAGFHDGKRWLYPPFNNLNLPKTSADKYLWSNLGINSDPLLQIAIWLPNGEQKATTATIKAVKLAGGSLRLLALPTENIIEANRALAVSNSALEWVEPLPISVSELAQQNLQQLKVILPKLWKSLQASGQIPKSDVPSLPQIQQKVGNWLVQRLDLTGNSKAETVFTISPEALATLNPGAKKPKGKESPRTVIFSDGGSIIYTDFAEKPQQNLSAIAKLAEVDSLALLVVNGKGYSLKRWSGKNQRFE
>NC_019751.1|WP_015198921.1|3974065_3974251_+|hypothetical-protein
MTTSSVTTRDLHSTFVSKTNKAYYREDQQDKFMHLQAEVDYLLQQLQNLKQEKSGTDTCEN
>NC_019751.1|WP_015198920.1|3973364_3973652_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MLDLREIYPLSDFQRNARQFIEQLQENQKPIVLTVNGKASVVLQDAASYQKLLDDLELAKSAATIRQSIAEVAAGQEQDAIEALEALRAKHDIPR
>NC_019751.1|WP_083866321.1|3973036_3973318_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MGEYSKENAAKWFNGLFNVVETLTSMPQRCPIAPERDLVGQDIRCLFYRKNYRILYTVEGEAVTIYHIRHTSQSVMTREEFLREPYREEILPE
>NC_019751.1|WP_015198919.1|3972519_3972882_+|hypothetical-protein
MIEGNFDDIGHIFFEIDLITTDGLNLPVDAMLDTGFTGFLVINKQDLEVLEWVYRGDEQMLTARGEAIFEKYLGKVFLDEQEYEIPVYAGDEITEVLIGSAWLKILPLVVNYQAGILTLG
>NC_019751.1|WP_015198918.1|3972205_3972523_+|hypothetical-protein
MTESVFKPKERRSRISLNSSLSPEELAKRKAEHEIFAQRCREIFDGVRPQIIDTYYGWYIAIEPESGDYFIDANIEIAHDRALQKYPHNHHCVFCLNETGATGTI
>NC_019751.1|WP_015198917.1|3970777_3971869_-|threonine-synthase
MTVSLSPATSYRQPWAGLIETYRPYLPVSESTPVVTLLEGNTPLIPAPSLARYIGRGVKVLVKYDGLNPTGSFKDRGMTMAITKAKEAGAKAVICASTGNTSAAAAAYARRGGMKAFVLIPDGYVALGKLAQALLYGAEVLAIQGNFDRALEIVREMSEQYPVTLVNSVNPYRIEGQKTAAFEIVDTLGDAPDWLCIPVGNAGNITAYWMGFCEYHQMGKCDRLPKMMGFQAAGAAPLVYGQPVAHPETIATAIRIGNPASWDKAVAAKSASMGEFNAVTDEEILNAYRILASEEGVFCEPASAASVAGMLKVKDQIPTGATVVCVLTGNGLKDPDTAIKHSGNQFKQGIAPDVLDVAKAMGF
>NC_019751.1|WP_041740688.1|3970238_3970679_+|hypothetical-protein
MGKDLTQEWLGEIQGLKQQLAELQNARNEAWESAEKWRKLYNTEAEQRRTDNQLAQQAIASLNGQLQKIKGIDDKTLPDADTSSAIHAEVIQLQSVEELQTKLIAATKERDRLLLALKTEQEEHAKTRTNLTTALGDAIDGMKQRS
>NC_019751.1|WP_015198915.1|3969169_3969865_-|sugar-transferase
MSAFIFSADGSAAEKITNHPDSIKYLQNSIHPSISSNTKRLLDIFGAVIGLLITACLFIPIACITVISDPGPIFYSQIRCGLNGKTFRIWKFRSMVVNADRLKHLVKNEAQGHIFKCVDDPRITPMGKFLRRTSLDELPQFWNVLKGDMSLVGTRPPTLDEVAKYKPHHWERLRIKPGMTGEWQVNGRSSIKDFETIVKMDINYQQKWSNAYDLMLIFKTIWVVVGKSNAY
>NC_019751.1|WP_015198914.1|3966383_3968354_-|acetate--CoA-ligase
MSQPTIESILQEKRIFPPSLEFSQNANIKSLEDYQQIYDFAKANPERFWAELAEKELHWFQKWDTVLDWQPPFAKWFVNGKINISYNCLDRHLTTACKNKAAIIWEGEPGDSRTITYAQLHREVCQFANVLKSLGVKKGDRIGIYMPMIPEAAVAMLACARIGAPHSVVFGGFSAEALRDRLNDAQAKLVITADGGWRKDAIVPLKPQVDKALADGACPSVENVLVVKRTAQDVTMTAGRDHWWHDLQKTVSADCPAEPMDSEDMLFILYTSGSTGKPKGVVHSTGGYNLYTHMTTKWIFDLKETDVYWCTADVGWITGHSYIVYGPLSNAATTVMYEGAPRASNPGCTWDIIEKHGVTIFYTAPTAIRAFIKMGDQHPNTRNLSSLRLLGTVGEPINPEAWIWYHKVIGGERCPIVDTWWQTETGGIMITPLPGAIPTKPGSATRPFPGILADVVDLDGNPANDNDGGYLVVRYPWPSMMRTVYGDDERFRRTYWEHIAPIDGQYLYFAGDGARRDEDGYYWVMGRVDDVLNVSGHRLGTMEIESALVSHPAVAEAAVVGKPDDLKGEEVVAFVTLEGTHTASDELSKELKSHVVKEIGAIARPGEIRFTEALPKTRSGKIMRRLLRNLAAGEEVSGDTSTLEDRGVLDKLRAGN
>NC_019751.1|WP_083866374.1|3976974_3978483_+|iron-uptake-porin
MSQVTSVSQLKDVQPTDWAFQALQSLVERYGCIAGYPDGTYRGNRSLTRYEFAAGLNACLNRVNELIATGTENITTREDLEKLKKLQEDFSAELVALRGRVDNLETRSAEVAANQFSTTTKLSGVSIIGVQGRSNNRADINPRDGIRDTKDPGTNTNLITLNQLFLTTQTSPTSYLVTGLLAGQGSTNPRNSNDITLGYEFNTNSSFVLSDLHYHQLLSPKLAVMIGTSNVNTITAFRGPNRVENAAIGPLSYFAQRNPILDIGYVGQAGIAVDWQFSKRASLQGIYSSVSANNPSQRNGLFDGNTTAGGQLLVTPTDSIDVSLYYLNNYAANGCLLTFIGDDCLTATDPMTNKRAPIQTNAIGSTINWQLSPKFTIGAWGGYTNSHIPGKSGKVETTNWMVYLNFPDLFGKGNLGGIYVGQPPKITNSDLPLGSNVPDFISGGSGKSGGQPGTTTHIEAFYRFQVTDNISVTPGIIHLIEPGNTPDSDSVTIGVLRTTFLF
>NC_019751.1|WP_015198924.1|3978820_3979015_-|hypothetical-protein
MSKEENIEKILLATAIVVQPKVVPVVTAYIAAKEAEETSKTLYKYSKKASKIAYKGFKKAKKFF
>NC_019751.1|WP_015198925.1|3979411_3979777_+|DUF2237-domain-containing-protein
MTNAKNVLGGELEICCTSPMTGFTRNGKCETGINDMGVHVVCAQVTEEFLKFTKLQGNDLSTPAPEYGFPGLKPGDGWCLCATRWQDALKAGVAPPIVLAATHEKLLEYLPLEVLKEHALD
>NC_019751.1|WP_015198927.1|3980043_3980994_-|branched-chain-amino-acid-ABC-transporter-permease
MHISIFLQQLLNGLSIGSTYAIFALGYTLVYSILGIINLAHGAVFTLGAYFTYALMGGTFGSSGLLANTTLPFKLPFATALIIGGILSGLVGVAIERFAFLPLRKQGSDALLTVVSSLGVALIVVNLILYMVGAENYTFPSDTYGNLPVSINFGTVENPIPIRTVQIIIFIVSVVIVAMMTWFINRTKYGKAMQAIAEDAMTASLLGINSDRLIVLTFFISSFLAGIAGTLLASSVSIAGPYFGITFGLRGLAVIVLGGLGSIPGAVLGGFVIGIIEAFVPGEYSGYKDAVAFGILFIMLLVRPQGLLGKRFIQKV
>NC_019751.1|WP_015198928.1|3981355_3982537_-|ABC-transporter-substrate-binding-protein
MSKTPTFKTILFTALSITITACTNSTKTSQTIPIGIAFAQTSNVALLGQEGSNGAKIAEKYFNDQGGINGTPIKLIFQDTGGEEQGAINAFQTLINKDKVVGIIGPTLSQQGFSAHPVADRAKVPVVAASNTAKGIPEIGDYVARVSSPASIVAPNSVKAALKQNPNIKKVAVFYAQNDAFNKIETEIFQKTVKDLGLEVVTVQKFQTTDTDFQSQATNGINAKPDLIIVSGLAADGGNLVRQLRELGYKGLIIGGNGLNSSNVLKVCKASCDGLIIAQAYSPQHPGKINKAFRDMYFQQYKVEPPQFSAQAFTAVQVYVEALNELDKKTKISTLQLPKIREDLNKQMLAGKYDTPIGEISFTPIGEIVQKDFYVAQIKMEKDGSAGKFEFIK
>NC_019751.1|WP_051036686.1|3982797_3983505_-|FAD-dependent-oxidoreductase
MKIAVVGGGAGGVELTLAIQAGLQQLGSRKLEMHLFHSGRELMSNSSTSLRKLLKKILQQRGVELHLGKLSQIEKVFPEQGYKKITNCPDLFQHVFWVTQASAAPWIQKTGLAVDAEGFILIDETLQSISHPHVFATGDIATMVNHPRPKAGVFAVRQGKPLFRNLRQAVWGKPLKPYIPQQNYLSLIGTGDGNAISTISYAYASRGKLTLPPHKLLWYWKDYIDRQFMRQFERL
>NC_019751.1|WP_041739691.1|3984786_3985125_-|hypothetical-protein
MINLVMIGGGHSHTIALRFFATNPVPGLHLTLISDAEDTPYSGMLPGHIAGFYSRSQCHINLRRLTISAQAEFYVERVVNLDLEKKLVICENILPIAFDIVSIDIGSKLKRI
>NC_019751.1|WP_015198929.1|3985249_3985861_+|pentapeptide-repeat-containing-protein
MLKQTLQRQIKQLNSQEIQERLLAINQLEQITKTHPSHHWYIMEALSNFLRQSAPIDNLDIICIDIQTALHVICNRNVQHDPKNQILDLSFTNIPNVNLDNTNLQQINFYQSNLTNASLKNANLHQAILAAANLKGANLERANLSSANLGAANLTNANLRAANLHRANLYLANLEGAIVQEANLWEANLREANFKGVRQPLNS
>NC_019751.1|WP_015198930.1|3986142_3986790_-|J-domain-containing-protein
MDLGDCYRILGLRTGASFADVKSSYRRLAQLYHPDINPEDRKAKDKFIALTEAYKLLLQVLPATDVVMPQSKATRQATTQQRTATTRKPSGTSPAAAEATTGVAKERVQTKPPNLAEIEQRLKWKTYEQLQRFLQERRFPQAIALAEALAERLPDDAEVRQWQAVAYQVWARALITEKQWLKARIYLKKAMKTDPHNKSLLYEVQCDFQKLEQIF
>NC_019751.1|WP_015198931.1|3987351_3987948_-|ATP-dependent-Clp-protease-proteolytic-subunit
MPIGVPKVPYRLPGGQQTQWIDIYNRLFLERIIFLGREVDDDIANKIIAEMLYLDSEDPGKDIILYINSPGGSVSAGLAIFDTMQHIKSDVATICVGLAASMGSFLLTAGTKGKRLALPHSRIMIHQPSGGTRGQATDIEIEAREIIRIRHQLNNIYANTTGQTLQKIEKDMDRDFFMSAAEAKEYGLVDRVIEEKPF

Crispr_ID: NC_019751_18

• CRISPR_ID: NC_019751_18
• CRISPR_location: 4624382-4624475
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_18

Consensus_repeat	Method
GTTCACCACCGTAGGTATCGCAC	CRISPRCasFinder

spacers of NC_019751_18

>18.1|4624405|48|NC_019751|CRISPRCasFinder
TTCAAGACTCTTTACTTCGGTAAAACAAAGCTTAACCCCAAGAGCGTG

CRISPR arrays and Neighbor proteins around NC_019751_18

CRISPR arrays

The CRISPR arrays of NC_019751_18

>merge|NC_019751|18|4624382-4624475|CRISPRCasFinder
GTTCACCACCGTAGGTATCGCACTTCAAGACTCTTTACTTCGGTAAAACAAAGCTTAACCCCAAGAGCGTGGTTTACCACCGTAGGTATCGCAC

>NC_019751|18|17|4624382-4624475|CRISPRCasFinder
GTTCACCACCGTAGGTATCGCAC	TTCAAGACTCTTTACTTCGGTAAAACAAAGCTTAACCCCAAGAGCGTG
GTTTACCACCGTAGGTATCGCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015199427.1|4635634_4636210_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_019751.1|WP_015199417.1|4616121_4616730_-|pentapeptide-repeat-containing-protein	unknown	unknown	gnl|CDD|224276
NC_019751.1|WP_015199424.1|4626295_4627519_-|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl|CDD|369642
NC_019751.1|WP_015199429.1|4637701_4638037_+|DUF2834-domain-containing-protein	unknown	unknown	gnl|CDD|371414
NC_019751.1|WP_015199423.1|4625521_4626178_-|glutathione-S-transferase-family-protein	unknown	unknown	gnl|CDD|223698
NC_019751.1|WP_015199412.1|4607714_4610066_+|DNA-helicase-PcrA	unknown	unknown	gnl|CDD|273429
NC_019751.1|WP_015199428.1|4636247_4637642_+|biotin/lipoyl-binding-protein	unknown	unknown	gnl|CDD|213754
NC_019751.1|WP_015199413.1|4610152_4611211_-|two-component-sensor-histidine-kinase	unknown	unknown	gnl|CDD|223715
NC_019751.1|WP_015199426.1|4629619_4635496_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|226415
NC_019751.1|WP_015199421.1|4623815_4624298_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015199431.1|4639404_4640106_+|DevA-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|274374
NC_019751.1|WP_015199415.1|4612910_4614356_+|folate/biopterin-family-MFS-transporter	unknown	unknown	gnl|CDD|341037
NC_019751.1|WP_015199418.1|4617450_4620522_+|filamentous-hemagglutinin-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|368641
NC_019751.1|WP_041739768.1|4627954_4629247_-|glycoside-hydrolase-family-10-protein	unknown	unknown	gnl|CDD|224563
NC_019751.1|WP_015199416.1|4614484_4615963_+|carotenoid-oxygenase-family-protein	unknown	unknown	gnl|CDD|226196
NC_019751.1|WP_015199414.1|4611218_4612376_-|hypothetical-protein	unknown	unknown	gnl|CDD|225825
NC_019751.1|WP_015199432.1|4640250_4641423_+|VCBS-repeat-containing-protein	unknown	unknown	gnl|CDD|379232
NC_019751.1|WP_015199419.1|4621129_4622917_-|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NC_019751.1|WP_015199430.1|4638061_4639219_+|FtsX-like-permease-family-protein	unknown	unknown	gnl|CDD|130253
NC_019751.1|WP_015199420.1|4623238_4623715_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015199427.1|4635634_4636210_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.09041e-14
NC_019751.1|WP_015199417.1|4616121_4616730_-|pentapeptide-repeat-containing-protein	gnl|CDD|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	2.40328e-23
NC_019751.1|WP_015199424.1|4626295_4627519_-|PQQ-dependent-sugar-dehydrogenase	gnl|CDD|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	1.18283e-109
NC_019751.1|WP_015199429.1|4637701_4638037_+|DUF2834-domain-containing-protein	gnl|CDD|371414	pfam11196, DUF2834, Protein of unknown function (DUF2834). This is a bacterial family of uncharacterized proteins.	9.92372e-31
NC_019751.1|WP_015199423.1|4625521_4626178_-|glutathione-S-transferase-family-protein	gnl|CDD|223698	COG0625, Gst, Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	1.82274e-40
NC_019751.1|WP_015199412.1|4607714_4610066_+|DNA-helicase-PcrA	gnl|CDD|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_019751.1|WP_015199428.1|4636247_4637642_+|biotin/lipoyl-binding-protein	gnl|CDD|213754	TIGR02971, devB-like_secretion_protein, ABC exporter membrane fusion protein, DevB family. Members of this protein family are found mostly in the Cyanobacteria, but also in the Planctomycetes. DevB from Anabaena sp. strain PCC 7120 is partially characterized as a membrane fusion protein of the DevBCA ABC exporter, probably a glycolipid exporter, required for heterocyst formation. Most Cyanobacteria have one member only, but Nostoc sp. PCC 7120 has seven members.	3.18002e-79
NC_019751.1|WP_015199413.1|4610152_4611211_-|two-component-sensor-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.04951e-45
NC_019751.1|WP_015199419.1|4621129_4622917_-|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.84856e-46
NC_019751.1|WP_015199431.1|4639404_4640106_+|DevA-family-ABC-transporter-ATP-binding-protein	gnl|CDD|274374	TIGR02982, heterocyst_DevA, ABC exporter ATP-binding subunit, DevA family. Members of this protein family are found mostly in the Cyanobacteria, but also in the Planctomycetes. Cyanobacterial examples are involved in heterocyst formation, by which some fraction of members of the colony undergo a developmental change and become capable of nitrogen fixation. The DevBCA proteins are thought export of either heterocyst-specific glycolipids or an enzyme essential for formation of the laminated layer found in heterocysts.	8.32997e-145
NC_019751.1|WP_015199415.1|4612910_4614356_+|folate/biopterin-family-MFS-transporter	gnl|CDD|341037	cd17484, MFS_FBT, Folate-biopterin transporter of the Major Facilitator Superfamily of transporters. The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.65715e-174
NC_019751.1|WP_015199418.1|4617450_4620522_+|filamentous-hemagglutinin-N-terminal-domain-containing-protein	gnl|CDD|368641	pfam05860, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	2.48142e-24
NC_019751.1|WP_015199414.1|4611218_4612376_-|hypothetical-protein	gnl|CDD|225825	COG3287, COG3287, Uncharacterized conserved protein [Function unknown].	1.20289e-81
NC_019751.1|WP_015199416.1|4614484_4615963_+|carotenoid-oxygenase-family-protein	gnl|CDD|226196	COG3670, COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	0
NC_019751.1|WP_041739768.1|4627954_4629247_-|glycoside-hydrolase-family-10-protein	gnl|CDD|224563	COG1649, COG1649, Uncharacterized protein conserved in bacteria [Function unknown].	5.05842e-152
NC_019751.1|WP_015199432.1|4640250_4641423_+|VCBS-repeat-containing-protein	gnl|CDD|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	2.93926e-06
NC_019751.1|WP_015199430.1|4638061_4639219_+|FtsX-like-permease-family-protein	gnl|CDD|130253	TIGR01185, membrane_spanning_subunit, DevC protein. This model describes a predicted membrane subunit, DevC, of an ABC transporter known so far from two species of cyanobacteria. Some experimental data from mutational analysis suggest that this protein along with DevA and DevB encoded in the same operon may be involved in the transport/export of glycolipids. [Transport and binding proteins, Other].	1.35272e-146
NC_019751.1|WP_015199426.1|4629619_4635496_-|AAA-family-ATPase	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	0

Protein sequences

>NC_019751.1|WP_015199421.1|4623815_4624298_-|hypothetical-protein
MILHISIDAHNPLQVATTLAEVLNGKIYKFFIPGSYLVMPFDNYGTHIVVFKEGDVWVPGNDVKAAQVLSAEPSKLVANHTAMVVPTTQEQIQQIGKREGWRVLTRKQGEGVPFSAIEFWVENRILFEFLTPEFVPQYLQTMQPEIIEKMFGLPIQLVPA
>NC_019751.1|WP_015199420.1|4623238_4623715_-|hypothetical-protein
MIHHISVAAHNPQHVSQVLAEILQGQSVPFPSHSGSYVALAFDSQGTMIEVHPLGTTLFPSNEVNEAVELRHNSASSNHTAIHAAISVPVSQDQIQAIADREDWRMVRCHRGDYFDVIEFWVENELLLEFLPPEIIQQYLSFMEPRSLQQQVAQSAAK
>NC_019751.1|WP_015199419.1|4621129_4622917_-|serine/threonine-protein-kinase
MCVRAVVSHGNKSAIHCINPDCKRPFPQPWGNRFCNSCGAPLQLNDRYVPLQTLGSGGFAQIYTVWDLQTQTEKVLKILVETSVKALELFEQEAAVLRHLRHPGVPKVESDGLFKLELCHPQPRQLHCLVMEKIDGMTLEEIQKKYPQGCPQGLVLNWLIQSVEILKHLHECKIIHRDIKPSNMMLRTAAFSRGAAQGDQLVLIDFGGVKQFNSNMRRPPNSTRLFSSGYSPPEQLIGGNVSPATDFYALGRTMVELLTGKNPADLEDSATGELQWRHLVTVKPQLGDLLDEMIKPDARSRPATTAMIQRRLTQMSQISVANGSISQLQQSISNVTQQITTAVKVSPPLFFSQVSAGVIQAARFVTQMVSTAILFVLQTVTTTVLACLSTIWAMLLTGSGAALGTMIGALLTYQTGWGEEFATLVSNQLMLVLPNNSPLTASDILLFASAGLGTACGFTTSGVFNQQRRYAIASITSIIGYCLSWFVLQGIATRSLPEAITGLILVAVTFLTLGLGFRSHHIVYSIITAFGTALSFAFLINLNLFPIDIFDPQTVTVSNLVLKTFFFTFVGVLISFFVAISHYTIIPWLRLLGWK
>NC_019751.1|WP_015199418.1|4617450_4620522_+|filamentous-hemagglutinin-N-terminal-domain-containing-protein
MDWIIARKIVFTFAVSLTLTQPVKAQIIPDQTLPQNSKISQPGCNNCDITGGTQVGNNLFHSFEQFSIPKNGSANFNNSVSIVNIINRVTGVSPSTIDGLIKTSGNANLFILNPNGILFGDGAKLEIGGSFFATTANSLQFGNLGFYSAVNPNSPSELLTINPSVFFFNQMKQQVQVNNSNLSVPANQSIFLVGGDVNLNNSKLQTPGGKIELAGIENNGSIGLAVENNKFSLIPNNSERANISLTNNAKIDVTGNGSGTVALTGRNLQITTGSVIAAGITQQLTGVPSPGDININVTDKFQISGDSIVANMANFRSNGKAGNINVNANSVEVTGGIIRTRTSGNGDAGDINIIGDNIYINNPAYKMPGRDTRLEDKPALDASNYTNDALNSGRGRSGNVSLNANNSITLIGLGIDEENKVISTYNRSGGNGGGGISLIANGAILFDNAYVVTSSFSRNGAGNVTLRGNGSISLINNSAINSISFVSGNSGDISLSSQGPILLRTGKINTQVANDIAVNQPSLGNAGSITISGQSVMIQDGTEIKSSSFAGGNSGEIKIIAPEFVEVSGNGIFPIPRGYRPRNYIYSSVTSSNEEKAIGNGGNIYISTNTLRLADGAHIRANTRGPGKGGDITVDAKVLELIGGGQIITTTSGKGDAGNITLNIKDQANISGFNPDYDQDFKQVVAKILADSSGNKVPKTATQLKNEALIKIGSINSASGIFADASDSSIGQGGDLTINTNSLEVRDHAKLTVTSDGLGSAGNANINAGTFILDRSSLTADTGSRNSDLNSEQATINIQSQNLFLFRGAKITTNASGSNVVGGNININTEVLAALQNSDISANSANFRGGKVFINAEGIIGTQFRNSLTDESDITATGASPELSGKVEIISPDTDPSRGFIQLREGLKDQSDQIDQLCGRGKKPLGRFVVTGRNGTIPSNPIINLMQGEIDYSELATLDESNATTKLSSIPDGLMVKNPEPNRIVEAQAIVRGADGILYLVDKAPTVRPNSRPTVSACADVGK
>NC_019751.1|WP_015199417.1|4616121_4616730_-|pentapeptide-repeat-containing-protein
MNFRILTTVAALLYFGLAGQAQAENQQDLEQLKATGNCPRCDLSGVNLSGANLGGVILRDANLKGVNFTGANLRGADLTGANLEGAVLNNANLYGASLTGATLKAASFENANLSFASLMGTNLEGTNFKGSTQQMTNYRGAYFRLTTTPSSVVTSDKPYGWSLQRDIKRDCNKFKLDGASGSVCATDQAPGSSMQPPQQVKN
>NC_019751.1|WP_015199416.1|4614484_4615963_+|carotenoid-oxygenase-family-protein
MQAYQASSTTEKSYSLESWQGGYKSLKQEYDYWIEDIEGEIPPDLSGTLFRNGPGLLDINEQQIHHPFDGDGMISKITFTDGRAHFRNRFVQTEAYIKEQKAGKILYRGVFGTQKPGGMLTNIFNFKLKNIANTNVIYWGGKLLALWEGAEPHILDPITLETLGKEYFNNVLSEGEAFSAHPHFDPSCAMDGGNPCMVNFSITPGLSTTIKVFELDLSGKVIRKHAHFVPGFCFIHDFVITENYCVFFQNPVKFNPIPFALGMRGAGECIKFDPNQPTRAIVIPRNPKNQEIKILEMQSGFVFHHANAFEKAGEIVIDSICYANLPEVEPGSDFRQTDFDALSPGQLWRFHLNLEQQTVQGKLLEARSCEFPSLHPELVTRSHRYLYLGAAHSETGNAPLQAFIKVDVETGEKLLWSAAPQGFTGEPIFVPRPNATNEDDGWVLGLVYDSQHHRSDVVILDAKNLTVIAKLHLQHHIPYGLHGNFVNQVFLG
>NC_019751.1|WP_015199415.1|4612910_4614356_+|folate/biopterin-family-MFS-transporter
MLVSSSGFSKVKELVKEKILFGNEPSAELIAILTVYFVQGILGLARLAVSFFLKDELRLSPAQVSALLGIVALPWIIKPLFGFISDGLPIFGYRRRPYLILSGLLGTISWICLATVVHSPVSATIAIALGSLSVAVADVIVDSLVVERARGESQADAGSLQSLCWGASAVGGLITAYFSGMLLQYFSDRTIFLITATFPLIVSGVAWLIAETPINKDQTQSENTAIDIKQQIKQLRQAITQKSIWLPTAFVFIWQATPTADSAFFFFTTNELHFEPEFLGRVRLVTSLASLVGIWIFQRFLKTVSFRVIFGWSILLSSALGMTMLLLVTHTNRSLGIDDHWFSLGDSLVLTVMGQIAYMPVLVLAARLCPPGVEATFFALLMSVSNLASLVSYELGAGLMHWMGINESNFDNLAVLVIITNLSTLLPLPFLNWLPGSDIEENPANLPPAAVHCHEQSLIPEFVPELILRQPKPRKKEEGGF
>NC_019751.1|WP_015199414.1|4611218_4612376_-|hypothetical-protein
MFKVATGHSIDPDSASAIAEVIKQCKLTLEGELPQAGILFAAIDFDHALILSQIQDAFPGIELIGGTTNGEISSSMGFQQDSLTLMVFASDEVEIKAGLGKGVSKNPISITKQAIEMAKAKISAPPQLCLTFPDSLSNNGVLILEGLKQSLGEEVPIIGGMTADDYTFSQTYQFFQNQVLSDAVPILLFSGNLQFSFGVASGWTPIGKPSCVTKVDGNVVYEIDGQRALDFYQYYLGAEKFAANYAIHALAVFEDSDRFYMRAPNGYDNESGSVTFFSAIPEGAMVQITDASRENILQASETSLKEALTNFPGKNITAAFLVSCAARRRILGTLTSEEYQLLKKHLPQVLPCCGFYAYGEIAPLTSKGQTQFHNKTFVTLLIGTN
>NC_019751.1|WP_015199413.1|4610152_4611211_-|two-component-sensor-histidine-kinase
MNSGNDSERVKELEKANRILEKQIARCQRDRKQLETDIAAKEFLLKQVISELQDSQSALASRSEELEITLQNLHNMQSQMLQSEKMSALGQMVAGVAHEINNPVNFIYGNLGYLESYNQDMLRLIQLYRCFFPNAPKEIEKLQNEIEIEFLQEDVTKILNSMNLGTNRIREIVLSLRNFSRLDEAEFKAVDIHQGIDNTLLILQHRLKATSTRLEIFVVRDYAILPDVECYPGQLNQVFMNLLANAIDALEEVDFQQNFAQIKIITSVVNSHWIEIAIADNGNGIPESIQSQIFNPFFTTKPVGKGTGMGLSISYQIICEKHGGKFNCSSSIGKGTEFTIQIPIKQPSHNAS
>NC_019751.1|WP_015199412.1|4607714_4610066_+|DNA-helicase-PcrA
MTTTIDFLSHLNPCQRRAVEHYCGPLLVVAGAGSGKTRALTYRIANLILQHRVDPENILAVTFTNKAAREMKERIQKLFAEQMAMREFGEKFDLLPEYDQVKLRSRVYRTVIKDMWCGTFHSLFSRILRMDIEKYQDENGRKWQKNFSIFDDSDAQSLVKEIVTKQLNLDDKKFDPRSVRYAIGNAKNKGLSPKEFELDQPNYRGRVISQVYSAYQDKLAENNALDFDDLILVPTRLFQQNSQLLNYWHGKFRHILVDEYQDTNKTQYELIRLLSTNNQSKNDWNWNNRSTFVVGDADQSIYSFRQADFTILLGFQDDFGDGLADDDTSTMVKLEENYRSCENILEAANHLIENNTQRIDKVLKPTRGAGEQIYLFKADDEVVEADFVINQIRRMETEHPNLNWGSFSILYRTNAQSRPFEDLLVKYQIPYTVVGGFRFYDRKEIKDILAYLKAIQNPADSVNLLRIINTPRRGIGKSTTDNLTRAAQELGTNLWEILSDETSVATLAGRAAKSINSFAGIIKKWQTQIETLPVAELVQGVIEDSGYVQDLHTQGTDEASDRIENIQALYNAVLEFQEENEGEENVNLQSFLEKTSLSSDLDNLKEGESAVSLMTLHASKGLEFPVVFLVGLEQGLFPNYRSMQDPASLEEERRLCYVGITRAQERLFISHARERRLYGSREPAMRSQFLDELPTELIATPGGKRQGYTKTSTGSTKQAKAKPSSEGETLTWQVGEQVLHRSFGIGEITHVFDSGSKTSVAVKFAALGTKIIDPRVAQLQRVE
>NC_019751.1|WP_015199423.1|4625521_4626178_-|glutathione-S-transferase-family-protein
MLKFYYNPVSTNARRVWVALLEKEIPFEAILVNLDGEQLGDEFTAINPLQRIPVIIDNQLRVVESLAILDYLEAKYPTRSLMPNQAEDIATVRMVETIAVNELQLATIPFTCQLVGLEVDDRKIENARQRIIAVMEFYENLLDGNTYFVNNKLTLADIVAGTLVPSLPHFGFSLNTYPNLTAWSQKLLERDSWQQTDLKADAIASAIPSIRAILERRS
>NC_019751.1|WP_015199424.1|4626295_4627519_-|PQQ-dependent-sugar-dehydrogenase
MKLTKTITGKLLISILCLEIISCTSPTSESANANNQQAETTKQVSQQTNNNQACTLVEDGFGTEGKVNIKVEEVVTGLEVPWGIAFLPNQDMLVTERPGRVRLVRDSKLVEKPVATINVTESGEDGLLGIATHPDVAKNRLFYVYYTTDINGSQVNRVERWRLSENGLSASSDRVILDNIPVAQFHNGGRIRFGADRMLYIGTGDARNPQSSQDVNSLSGKILRVTPDGQVPQDNPFAKNPVYITGIRNTQGFDWSDKSTLWVTDHGPSGELGRSGHDKVSVARAGDNLGWPTTYRCESGKGLVTPSIVWRNALPPGGAAIYTGNSIPEWKGNLIISTLRSQHLQRVVFNPQSPEQVQLHEVYLQGKYGRLREAIMGSDGELYITTSNCDGRGNCPSQKDKILRITR
>NC_019751.1|WP_041739768.1|4627954_4629247_-|glycoside-hydrolase-family-10-protein
MTIKFHHNNMRWLNWVKNSFLKPAKFNFIVPWWERTIHILPTSLKSIAPLLFILSLISVLLLNSFTPVIAQQSRPEIRGVWMTNNDFDILRDRAKVQDAVTKLRQMNFNTVYPVVWNSGYAMYPSAVAQKAEIQPFVYKGTDGHDIIADLTNQAHRQGLLVIPWFEFGFMAPPTSELALNHPEWLTRKRDGTDTSISAGGEVVWLNPFHPEVQEFISNLVLEIVTQYDADGIQFDDHMSLPYEFGYDPYTIALYTQETGNPPPSNPQDQMWMRWRADKITTFMVHLNQEVKARKPNLIFSVSPNYYDFAYKFHLQDWLTWLRLNIIDELIVQVYNPNLQSFTNNISRPEMQEALQSIPTGVGIMTGLRNSPVPIQQIQSQVRLVQERGLGAVFFYYESLWDSGLESASERKSAFQALFPNPAFRSANRQQ
>NC_019751.1|WP_015199426.1|4629619_4635496_-|AAA-family-ATPase
MLTTQVNIPGYQVDKQIYNGCKTIVYRGYRESDSLPVAIKLLKNPYPTFSELVQFRNQYTIAKNINSSLILQTYSLETYKNSYILIMEDFGGISLNQWEGKEKISANLVDFLQIAIALTDALDILYRHNIIHKDIKPANILINPDTKKIKLIDFSIASLLPRETQIPTNPHGLEGTLEYLSPEQTGRMNRGIDYRTDFYSLGVTFYELLTGGLPFQSDDPLQLVHCHIAKQPPHTAHNGEIPQVLWDIIMKLMAKNAEDRYQSALGLKCDLENCLSQIKEAGKIEDFKIAQWDLCDRFIISDKLYGREAEIATLLTAFERVTCGATEIMLVAGFSGIGKTAIVNEIHKPIIQQQGYFVQGKFDQFNHNIPLSAFVQALRDLMRQLLSESDSKIEYWKSQILSAIGNNGQVIIEVIPELEQIIGSQPIVPQLSTNAAQNRLNLLFQKLIAIFTRKEHPLTIFFDDLQWADSTSLNLIKLLTTEITPGYLFIIGAFRNNEVSSNHPLICTLNEIKNAGITINTITLLPLSVSDNNRLIADALKCTLEESLDLTKFIYQKTQGNPFFNNQFLKSLKENGSITFNMDAKAWEFDINQIYTLDLNDDVVDLIVTQLKNLPQSTQNSLKLAACIGTSFKLKILSIITEKSQIDTANDLWQALKEGFILPRNEASKFSQSNIVQDNNKLDNIFIFEDCEYKFLYDRVQQAAYSLIPEEEKPATHLKIGQLIIENNSPENCQENIFEIVNQLNIGRALINQESEREQLIILNLTAVRKAKAATAYSAASNYLAICIELLPFDSWNSHYDLTLKLYEEAVEIAYLNADYQLMEEMIEIVLSQAKTLIDKIKVYETKILAIKAKSQLRESIEVGLELLKLLDVEFSKQPTSEDIGEALTETLLAWKEISIPSLLGAKEMSDPIKLAAMRILTQLTPSAYQAFPSLMPLLIFKQIIFIIAEGNCPISAFSYADYGLVLCGIVGDLDAGYKFGELALNIIDRFQGDFYKCRTYFIVYSHIHHWKSPLSASLPFFLEAYQVGLAHGDLESSALNAQMYCCHAYFVGKELVALASEMDIYRQAVEELKQQGALTSLEICQQTVLNLLGHSDDPCQLVGDIYDENESLPLLKTLHNRAAIYHLYYHKTVISYLLGKYQQAAFYASLVESYADIMPAAFTIPLFNFYNSLLSLQLYTYAETKQEKNNYLKKVVTNQRQLKQWSNSAPMNHLHKFYLVEAEYHQLLANYQEAIEYYDRAIRLAQENKYIQDEALANELAAKFYLTWGKERIAQSYIIDAYYCYVHWGAKVKIEDLEQRYPQLLAPILQKQQQSLNANEIIPIASFHSSKAATLGINSISETLDLATIIKASQTLSREIELDKLLIALLEVLLENAGADKCVLLLPKNEQWVIEGICQLGQSPIVLQSIPMQLGQYLPISLINSVKHSLKASVIFNAVAHANLAVDPYVLHQRPKSVLCTPILNQGKLVGILYLENSLTTGAFTSDRLELLNLICTQAAIALENARTYQQAQNYGKQLEQSLEALNASEARFQKLADNIPGVIYQLRLNQNGSFSMSYISSGCYELYEVTAEELISTGRSIRSFEHPEDVTKIDEAILNSAQNLTPFQYQWRIITPSGQIKWIQALSQPERQENNELIWDGVILDISQRQAALQERKRAETERQKKAEALETALQELQQTQIQLVQNEKMSALGNLVAGVAHEINNPIAFLGGNIQPALEHIQDLFGLVDLYQEKYPHPEAEIENEIIAIDLDYIREDLPNLVGSMREGVKRICEISNSLRTFSRKDSNCPVACNLHDGIDSTIMILKHRLKASDSRPEIQIIKQYGEIPSIECFAGQLNQVFMNLLANAIDALEESNIGYTYAQIKANPNLIIITTQIADNPRQIIISIKDNGKGMTPEVKQKIFDHLFTTKSVGKGTGLGLAIARQIVVEKHHGAIDVNSTLGEGSEFLIRLPF
>NC_019751.1|WP_015199427.1|4635634_4636210_+|TetR/AcrR-family-transcriptional-regulator
MPKIVDHKQYRKELLAKSFNIFAERGYGAVTMRHLSQGLGVSTGTLYHYFPSKRALFEQLVEEETTRDILIVSAEFKEIEGIENKLNFVGRYLTENQDYQVKWMYIMVDFFQTQDAEEVRQNDFWERLLQRFVLLVYDLLGVEDLILANFVISFIDGIIIEKILANEMVDFNEQCQLLGKMLSLYVNNLKK
>NC_019751.1|WP_015199428.1|4636247_4637642_+|biotin/lipoyl-binding-protein
MTLNLFTKPGNKQMIALIIGAIVITGGVIYYGVSQFGIIGKATSPKAETLPEIKKVTALGRLEPEMKVIQLSAPSNLDGDRVLAVMVAEGDKVSKGQIIAVLDSRDRLRDAALVAEKQVAMAKAKLAQVKAGAKTGDIRAQQAAVGRFQAQTQGDKIGQQETIARLQAQWQGDRVGQQEVIDRLAAQLVGDRDAQLATIGKLSAELKNAEAEYERYRQLSQQGAISASLFDSKGLSVETARQQLSEAKAILTRIEATGNKQISEARTVLTRIDATNSKQISEAKIALSRINATGGKQVTEAKATLSSIAEVRNVDITVAQAEIENATASWQQAKTEAEEAYIRAPMAGQILKIHSRPGEKISDDGIAEMAQNQQMLAVAEVYQSDIAKVKLGQKAIITGQAFTGEVKGTVSQIGLQVNRQNTFANQPGENMDRRVIEVKILINQEDVNRVSGLTNLQVQTAIEL
>NC_019751.1|WP_015199429.1|4637701_4638037_+|DUF2834-domain-containing-protein
MLQLTYFLLCLLGFTLPISQFIPFLVEHGLNLELFIHQLFINRISTFFGMDVFVSAVVVIVMIFAEGTRIQMRNLWIPILCLVVGISFSLPVFLLMRQKHLHHQQSIITPI
>NC_019751.1|WP_015199430.1|4638061_4639219_+|FtsX-like-permease-family-protein
MPPKIFKKTPLAWRQLMKEKTRLLVAVAGIAFADILMLLQMGFESALYDASILPHRQLNADLVLIDPYMQTLFAVKSFPRERLYQTLASEGVVSTTPVYIASGQWRNPETRLERTILVWGVDPLLKTFKMPEVNQNLGQIKQLNTVLFDIAGRPDYGVTKENFLTFETELNSKSVNVEGLFINGASFAADGNIITSDSTFLNLFADRKSEKIELGLINLQPGSDVKRIQKQLIANLPKDVSVLTTEEFAQIEKTYWANSTAIGFIFGIGVGVGFIVGIVIVYQILYSDVSDHLPEYATLKAMGYTDGYLFGVLMQEALLLAVLGYIPSFFVVSGLYVLAANATMLPIVMTAERAVTVFVMTIVMCSISGFVAMGKLRSADPADIF
>NC_019751.1|WP_015199431.1|4639404_4640106_+|DevA-family-ABC-transporter-ATP-binding-protein
MAVISISNLNHYFGEGGLRKQALSDINLQIQAGEIIIMTGPSGSGKTTLLTLMGGLRSAQEGSLNILGQEICGANKRELTQLRRNIGYIFQAHNLMMFLTAKENVRMSLELHEEFLHQDLNAVAVEILEHVGLGERVDYYPENLSGGQRQRVAIARALVSRPKIVLADEPTAALDKKSGRDVVELMQKLAKEQGCTILLVTHDNRILDIADRIVYMEDGRLVSNDVDLMTKMS
>NC_019751.1|WP_015199432.1|4640250_4641423_+|VCBS-repeat-containing-protein
MFESNKSSELSTDARQSAYVQSSGGFTDKLDTTSSISKSSLFSANPNPNPYVTSAAINPDFNGDGKTDKIWFNTQTGETAIWLMDGGNPNGVMLPQSAAEWDMKIADVNGDNKTDLFWRNKNSGELVVWVMDGANIVSQTSVATLDKAWDFSIADTNGDRKTDLVWNNKQTGDNAVWLMDGGTITSAEMLTKTDSNWTSRAGDFNRDGKTDLLWHNKSTGENAIWYMDGTKVNGAGLQSFGAGWDLTSGDFDGDLKTDVLWHNNQTGENKLWTFDITGAAVQSDLATMGAGSKYSIADFDGNGKTDIIWRDESTGTNKVWLMNGATVTEQDVPQLGSNWKYSVGDFDGNGRADIFWNNADTGENMIWSVDDQGNPISTNTVTTPKGWITY

Crispr_ID: NC_019751_19

• CRISPR_ID: NC_019751_19
• CRISPR_location: 4750254-4750354
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_19

Consensus_repeat	Method
TCTTGGGGACGATTCCCCGCTTG	CRISPRCasFinder

spacers of NC_019751_19

>19.1|4750277|55|NC_019751|CRISPRCasFinder
GGCTTTTTGAAGGTTTGCTTGGACTTCTTCTAATTGTGCCTGTGCTTGGGCAATG

CRISPR arrays and Neighbor proteins around NC_019751_19

CRISPR arrays

The CRISPR arrays of NC_019751_19

>merge|NC_019751|19|4750254-4750354|CRISPRCasFinder
TCTTGGGGACGATTCCCCGCTTGGGCTTTTTGAAGGTTTGCTTGGACTTCTTCTAATTGTGCCTGTGCTTGGGCAATGTCTTGGGGACGGTTCCCCGCTTG

>NC_019751|19|18|4750254-4750354|CRISPRCasFinder
TCTTGGGGACGATTCCCCGCTTG	GGCTTTTTGAAGGTTTGCTTGGACTTCTTCTAATTGTGCCTGTGCTTGGGCAATG
TCTTGGGGACGGTTCCCCGCTTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015199512.1|4746449_4747037_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_019751.1|WP_015199521.1|4756671_4757880_-|DUF1624-domain-containing-protein	unknown	unknown	gnl|CDD|226749
NC_019751.1|WP_015199510.1|4743902_4745399_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|130902
NC_019751.1|WP_015199516.1|4751992_4753450_+|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|223594
NC_019751.1|WP_015199507.1|4742718_4743066_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_085953345.1|4753575_4754196_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NC_019751.1|WP_041739778.1|4755951_4756560_+|CAP-domain-containing-protein	unknown	unknown	gnl|CDD|225218
NC_019751.1|WP_015199511.1|4745615_4746218_-|hypothetical-protein	unknown	unknown	gnl|CDD|377472
NC_019751.1|WP_015199509.1|4743400_4743661_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015199514.1|4747967_4749260_-|FtsX-like-permease-family-protein	unknown	unknown	gnl|CDD|182528
NC_019751.1|WP_015199524.1|4760293_4760722_+|peptidylprolyl-isomerase	unknown	unknown	gnl|CDD|223976
NC_019751.1|WP_015199505.1|4741177_4741423_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015199508.1|4743162_4743339_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015199519.1|4755116_4755746_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015199523.1|4758858_4759986_+|AI-2E-family-transporter	unknown	unknown	gnl|CDD|223701
NC_019751.1|WP_015199518.1|4754586_4754916_+|YbjQ-family-protein	unknown	unknown	gnl|CDD|376657
NC_019751.1|WP_015199525.1|4760787_4761195_-|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl|CDD|376583
NC_019751.1|WP_015199513.1|4747190_4747862_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224059
NC_019751.1|WP_015199522.1|4758100_4758547_+|peroxiredoxin	unknown	unknown	gnl|CDD|239315
NC_019751.1|WP_015199506.1|4741507_4742413_-|TIGR01777-family-protein	unknown	unknown	gnl|CDD|187553

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015199512.1|4746449_4747037_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.97304e-12
NC_019751.1|WP_015199521.1|4756671_4757880_-|DUF1624-domain-containing-protein	gnl|CDD|226749	COG4299, COG4299, Uncharacterized protein conserved in bacteria [Function unknown].	4.01334e-132
NC_019751.1|WP_015199510.1|4743902_4745399_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl|CDD|130902	TIGR01843, Hemolysin_secretion_protein_D_plasmid, type I secretion membrane fusion protein, HlyD family. Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking].	2.16591e-69
NC_019751.1|WP_015199516.1|4751992_4753450_+|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl|CDD|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	2.79597e-85
NC_019751.1|WP_085953345.1|4753575_4754196_-|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	6.31669e-14
NC_019751.1|WP_015199511.1|4745615_4746218_-|hypothetical-protein	gnl|CDD|377472	pfam05145, AbrB, Transition state regulatory protein AbrB. Bacillus subtilis respond to a multitude of environmental stimuli by using transcription factors called transition state regulators (TSRs). They play an essential role in cell survival by regulating spore formation, competence, and biofilm development. AbrB is one of the most known TSRs, acting as a pleotropic regulator for over 60 different genes where it directly binds to their promoter or regulatory regions. Many other genes are indirectly controlled by AbrB since it is a regulator of other regulatory proteins, including ScoC, Abh, SinR and SigH. Hence, AbrB is considered a global regulatory protein controlling processes such as Bacillus subtilis growth and cell division as well as production of extracellular degradative enzymes, nitrogen utilization and amino acid metabolism, motility, synthesis of antibiotics and their resistant determinants, development of competence, transport systems, oxidative stress response, phosphate metabolism, cell surface components and sporulation. AbrB is a tetramer consisting of identical 94 residue monomers. Its DNA-binding function resides solely in the N-terminal domain (AbrBN) of 53 residues. Although it does not recognize a well-defined DNA base-pairing sequence, instead, it appears to target a very weak pseudo consensus nucleotide sequence, TGGNA-5bp-TGGNA, which allows it to be rather promiscuous in binding. The N-terminal domains of very similar sequences are present in two more Bacillus subtilis proteins, Abh and SpoVT. Mutagenesis studies suggest that the role of the C-terminal domain is in forming multimers.	0.00909232
NC_019751.1|WP_015199513.1|4747190_4747862_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	4.98316e-118
NC_019751.1|WP_015199514.1|4747967_4749260_-|FtsX-like-permease-family-protein	gnl|CDD|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	3.42406e-70
NC_019751.1|WP_015199524.1|4760293_4760722_+|peptidylprolyl-isomerase	gnl|CDD|223976	COG1047, SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones].	1.49295e-41
NC_019751.1|WP_041739778.1|4755951_4756560_+|CAP-domain-containing-protein	gnl|CDD|225218	COG2340, COG2340, Uncharacterized protein with SCP/PR1 domains [Function unknown].	2.3139e-32
NC_019751.1|WP_015199525.1|4760787_4761195_-|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl|CDD|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	1.18039e-83
NC_019751.1|WP_015199523.1|4758858_4759986_+|AI-2E-family-transporter	gnl|CDD|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	1.6279e-65
NC_019751.1|WP_015199518.1|4754586_4754916_+|YbjQ-family-protein	gnl|CDD|376657	pfam01906, YbjQ_1, Putative heavy-metal-binding. From comparative structural analysis, this family is likely to be a heavy-metal binding domain. The domain oligomerizes as a pentamer. The domain is about 100 amino acids long and is found in prokaryotes.	8.45614e-36
NC_019751.1|WP_015199522.1|4758100_4758547_+|peroxiredoxin	gnl|CDD|239315	cd03017, PRX_BCP, Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing and detoxifying hydroperoxides. The protein was named BCP based on its electrophoretic mobility before its function was known. BCP shows substrate selectivity toward fatty acid hydroperoxides rather than hydrogen peroxide or alkyl hydroperoxides. BCP contains the peroxidatic cysteine but appears not to possess a resolving cysteine (some sequences, not all, contain a second cysteine but its role is still unknown). Unlike other PRXs, BCP exists as a monomer. The plant homolog of BCP is PRX Q, which is expressed only in leaves and is cellularly localized in the chloroplasts and the guard cells of stomata. Also included in this subfamily is the fungal nuclear protein, Dot5p (for disrupter of telomere silencing protein 5), which functions as an alkyl-hydroperoxide reductase during post-diauxic growth.	1.21844e-71
NC_019751.1|WP_015199506.1|4741507_4742413_-|TIGR01777-family-protein	gnl|CDD|187553	cd05242, SDR_a8, atypical (a) SDRs, subgroup 8. This subgroup contains atypical SDRs of unknown function. Proteins in this subgroup have a glycine-rich NAD(P)-binding motif consensus that resembles that of the extended SDRs, (GXXGXXG or GGXGXXG), but lacks the characteristic active site residues of the SDRs. A Cys often replaces the usual Lys of the YXXXK active site motif, while the upstream Ser is generally present and Arg replaces the usual Asn. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.65025e-143

Protein sequences

>NC_019751.1|WP_015199514.1|4747967_4749260_-|FtsX-like-permease-family-protein
MIKLKPINKKTPKPIDTRTVPLLEILSMAIETLWSNKLRTGLTMLGVIIGISSVIAITSVGQGVQKGVEQQIQSLGTNVLQVLAGAARSGNNISQGLGSSSTLTWEDSKAIAKQAPSAEIVSAYLQRSAQVVYEGQNTSTIIYGTDLNYPEARNTFTQQGRFFTQEELDTAAQVAVIGPTVQKTLFSQGANPIGERIRIRGEAYEVIGITEAKGSQGPMDRDDQIFIPLTSMSARLVGNNALAGISVNGILIKASDQQKLEAAQFQVTNILRLRHNIYPPQPDDFRITNQADIISTFTNVVGLFTVMVVAIAGISLVVGGIGIANIMLVSVVERTREIGIRKAVGATNSAILNQFLTEAIVISSLGGGIGIAIGIIIAFAAATVFKFPFVISLLSIIVGFLLSLIVGLIAGVIPARNAAKLDPINALRSD
>NC_019751.1|WP_015199513.1|4747190_4747862_-|ABC-transporter-ATP-binding-protein
MPTMIWMESITKTYQLGEVSVPILKGIELAIEEGEYVSIMGASGSGKSTLMNILGCLDRPTGGDYIFEGRNLTTFNDDELAYIRNQRIGFVFQQFNLLARATALDNVMLPMVYANLPKPKRRERALAALERVGLAERTTNRPSQLSGGQQQRVAIARALVNRPALVLADEPTGALDTETSHDVMKLLTELNEQGITIVIVTHEPDIAAQTKRIIRVQDGLIVN
>NC_019751.1|WP_015199512.1|4746449_4747037_-|GNAT-family-N-acetyltransferase
MTWETLSENGEYKVSDFKVLQTADIQHFLPLFKELTEFNERFLLSMLRWCGYGRKRNREVPVWSVYVAFHLNKPIGVTGVYCEQEDPSERCWLGWFGIIPDYRRKRVGSYLFNTTCKISRSKGFSSLYIYTGGSNEKAISFYESIGCNKLGFGYEVFPNSCFDNFSKSNMILAFDLTSTDKVNSKSFPLLPLADS
>NC_019751.1|WP_015199511.1|4745615_4746218_-|hypothetical-protein
MKYRSILWLNGLCLLIVITLLAYTKYINPLAGALFMPPHFPNSLTEGLLTNIFQLLCAVPPLICAFSFIVLKKIAPQNKNNRFIFYSALVTLGFLMNEKYRIHIIFLADFGIPKFLTIVVYALIGLYYGITFRREIIKSTPYVLLLIGLGLLISGIFVDLLHLGSSSSSPLEGIPKLFSGINVALYYWLICYKEVVNSFK
>NC_019751.1|WP_015199510.1|4743902_4745399_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MRNSLAANAAQARQTKQVFARPEDQLSYELGKAVQELPPLYTRVLAGTLSAVVFSAIAWAYFSQIDEVATAPGELIASTQVRPVTSIGNGSIVAVRVKEGDRVTKNQVLVERDPEYQQLDVTRLSQSAKLIKEDISRLNAERTGNKDAGSQMQDELLSARLKDFESRQAAAEAEAKRQTALIDQAKVRLARLQENLTNARTSQENSKANYENSLLLRTKVEENLALAQKREESMRKLVASSAVPRLDYLEAQDRLNRAKAELTRAGDEIINSQNKITEATDKATSLEKDIAAQVQEVRQAQQAYQSAKNQSDRVASERQSEVLTQMNKRREELTDVSGKLDQARKQSDYETIKSPVSGTIYSIKATKGPVQSGEELLSILPDGEEILLEVKVLNRDIGFIRQGMKAKVKMATFPFQEFGTIDGEVVKISPNAIVDKELGLVFPTRIKLKKDRLTVRGEEVVFTPGMSASGEIVTRKKSVLTFIMEPITRRFSEAFSVR
>NC_019751.1|WP_015199509.1|4743400_4743661_+|hypothetical-protein
MDSQPQQPGTQFLTSEESAKVDAALLSSSEKFLTRITISSLRLLKHVAEENNVPIEDLTVQQVIQWFENDARIRREEGAEAAFLKW
>NC_019751.1|WP_015199508.1|4743162_4743339_-|hypothetical-protein
MKEAGGKRQRAEGTIGRGFRPQWDLKPLLPLVTAEDRKQYSLLPSAFPDNATDGLVGV
>NC_019751.1|WP_015199507.1|4742718_4743066_+|hypothetical-protein
MARYTCSFIVSVAIDHLQPLMIELLESSGLDVQYYTPDYIMAREAPGSIDFPKLVTVEILIDKTTATDLETRMTLVGKSAELPLKLDNHCRQVFDFIKQEIEHSRHWHLIQSLAG
>NC_019751.1|WP_015199506.1|4741507_4742413_-|TIGR01777-family-protein
MKVAIAGATGFVGSRLVERLHKQGMSVVVLSRNTTHAERVFPNTAFPNVEIVNCDSWQNAIASCDGVVNLAGEPIAEGRWTPERKQEILNSRKQTTQTIVQAISNSSQKPQVLVNASAIGYYGTSEAATFDENSPAGQDFLAEVCQTWENEAKKVTNSGVRLVILRLGIVLGNGGAMGKMITPFKLFAGGPIGSGKQWFSWIHIDDVVGLIVEALTKPEMQGVYNATAPQPVKMTEFCQVMGKVMNRPSWLPVPSFALEALLGDGAIVVLEGQQVLPTRTLASGFGYKYDKLQSALVEIIK
>NC_019751.1|WP_015199505.1|4741177_4741423_+|hypothetical-protein
MKEKLLNWLNLVLVADVFLVLLGFIWFAIAIVGEATGINLGLDLWHQLWQPLFNPAIGILMGGALLSGIISWFSKKFLSNH
>NC_019751.1|WP_015199516.1|4751992_4753450_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MQLQVKPITKSQNELDNFWQENIQPLFTEESLCFQVKTTDGKEVRYVNLDNGATTAPFAPVKRYVEEMLDCYGSVHRGSGQKSLISTREYDNSRDVIRNFVGASQNNYVIFAKNTTEAINAAATLWAKIPGKILVSDIEHSSNLLPWVVNNEVVQYRTEADGSVDIAKIEAILVAHKDLPVTEQIKLLTITGASTITGYKPPIYEIAALAHRYGIKIFADLCQLVQHDRVDMLPDNDPCHLDFVAFSGHKMYAPYGTGILVGSKNFFDQFHPYQIGGGNLPYITRNLEIKRFYTERAHDPGTPNAMGAVAIAKSIQIIESLGREEIAHYEHSLVEYTFKQLSSIPGVRIHIAGDGIAHVIPFDIDGFDGRLVAEILAQEYGIGVRAGAFCTYEYIRKLKGISDEQDEVIAAEVDQGITRNIPTIIRASFALSNNFEDCQRFIDAIAQITENGFAHYLPKYSQDNTTGVWTALAASEYTHSGYRLT
>NC_019751.1|WP_085953345.1|4753575_4754196_-|tetratricopeptide-repeat-protein
MPTLAQAQTLVAQRTTQEVKQMLEEGKRLVDAGDYGGAIAIYKEAAAADPRNATIQSGIGYLYAQQGNLPSALIAYRRAVALNPNNDDYQYALGYVSGNLGDNRAAKDAYRKAIQINRNNANAYLGLATILLRLGETNNAMWATEQAMNLEPNNPQVFELRGTFLMKQGKSKDAIALFRKARDLYEKQGKQDNANRVEATIRKIRS
>NC_019751.1|WP_015199518.1|4754586_4754916_+|YbjQ-family-protein
MILTTTDVLQGAVVDSYLGIVTAEVVYGSNFLRDFVASIRDIIGGRTVSYERLFEQGQQKALAELQERAKRLGANAVIGIAVDTGTINVDQSGVLMLITATGTAVKIRQ
>NC_019751.1|WP_015199519.1|4755116_4755746_+|hypothetical-protein
MSYVNRMDEGDVISEPAVVARVADYHDRVRWGPIISGLLVALATQLVLSAMFAAIGAGNIEASGRPRTIAGDVAGGVGIWSIIALLISLFTGGWVTARACGPMNRNTAILNGAILWATTLAVSSWLLASGVSGAFGVAASNAGEVVNQIQGRALDVPQTNVSAQQARELASGVRQSLWWFVFGSILGLVTSIAGAVTGARSPRRNGNYS
>NC_019751.1|WP_041739778.1|4755951_4756560_+|CAP-domain-containing-protein
MKTVTHPWLSPLEEQVVVEMNKARSCSNYEGASHSRSYIEILESYKQRFDGKRVWLSSDVYLQTQEGVKAVDEAIKYLKKVTPAPPLTVSRGMSLAAQDHVKNQGIKGITGHNGSDGSNPFLRMERYGKWLVTAGENISYGSYMPEDIIMQLIIDDGVPDRGHRVNIFNPAFKLAGVAFGIHAKYRQMCVITYAGGYRENMI
>NC_019751.1|WP_015199521.1|4756671_4757880_-|DUF1624-domain-containing-protein
MRLTSLDVFRGATIAGMILVNMVSLAEPNVYPALLHADWHGCTLADLVFPFFLFIVGVAMSFSFAKYTDVIPKVEKEKDAIGALQQFLAKESSAAGGAKPPYKKIFRRGAILFALGLFLNLFWNSKNLPYFDFSTLRIMGVLQRIALTYLFASLIVLKLPKKAQWIVAGVLLVGYWLLMMYVPIPEYGAGEIGTRTGNFAAYIDRFIIPKAHLYKGDGFNNFGDPEGLFSTIPAIVSVLGGYFSGQWIRSQPVKTRTSLGLALAGIGCLIIAWLFALDFPINKKLWTSSYVIFTTGWALLLLAGCYELIEVQKIRSWAKPFEVLGMNAIAIFTASVLFIKILAKTVIGTGDTATNLYTVIYKNLFASWAGGLNGSFLFAFVTVLLWLGVAWMMYRQRLFIKI
>NC_019751.1|WP_015199522.1|4758100_4758547_+|peroxiredoxin
MAIKTGDAAPDFSLPSQNGTSVSLQDFRGKSVVLYFYPKDDTPGCTAESCAFRDQYEVFKSAGAEVIGISGDSPASHQKFAEKYQLPFTLLSDQGDKVRNAYGAKSLFGLFPGRITYIIDGNGVVKHVFDSMLNFQGHVEESLKILNS
>NC_019751.1|WP_015199523.1|4758858_4759986_+|AI-2E-family-transporter
MKLGQWIGLLAIVLSSYILWQIREALLLAFAAVVLATTLNRLSRRFQRLGLKRGISVIISVLIFIALVVGFFWLIVPPFVDQFQELTRKVPQGLQRVNFWLLEQKTHIPPQLITYIPDINRLVQEAQRFISPVLGSSFAFLSGSLEALLKILLVLVLTGMFLADPKAYRKVFVRLFPSFYRRRIDGILDKCEESLEGWVTGAFIAMSAVGIMSVVGLSILGVPAALALGILAGFLNLIPNLGPTMSVIPAMAIALLDAPWKSLAVFIVYLVIQQIESNFLTPYVMARQVSLLPAVTLISQLFFVTFFGFLGLFLALPLTVVAKIWVQEILIKDILDQWNSDAERETEFVMISEVQNVINVQQPPPNDVPTKKEEE
>NC_019751.1|WP_015199524.1|4760293_4760722_+|peptidylprolyl-isomerase
MTQAKIGDTVTVHYTGKLSDGTVFDSSNGGDPLEFTLGEGELIAGFENAVVGMNTGETKTAEIPVEQAYGLYNPDMVIEVDREQMPAELEPEVGQQLQLEQPTGEMIPVVITKVEESLVTLDANHPLAGEDLVFDIELVAIA
>NC_019751.1|WP_015199525.1|4760787_4761195_-|peptide-methionine-(R)-S-oxide-reductase-MsrB
MATSQNEFKIQKTDQEWKESLTPEQFQVLRKHGTERPHTSPLNKEYGEGTYVCAACGTPVFTSTTKFDSGTGWPSFYQPIEEGIDTTVDRSFFMTRVEVHCKNCGGHLGHVFNDGPAPTGKRYCINGVSLKFDQQ

Crispr_ID: NC_019751_20

• CRISPR_ID: NC_019751_20
• CRISPR_location: 4840951-4841096
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_20

Consensus_repeat	Method
TTTGGGAGTGCGATTTTGTTAGGTTCGTTGGAGAATGCGATCGCCCTTT	CRISPRCasFinder

spacers of NC_019751_20

>20.1|4841000|48|NC_019751|CRISPRCasFinder
GTGATAAGGGTTGGTTTGGAAGTGCGATCGCTGTTTGTTAGGAGTTGC

CRISPR arrays and Neighbor proteins around NC_019751_20

CRISPR arrays

The CRISPR arrays of NC_019751_20

>merge|NC_019751|20|4840951-4841096|CRISPRCasFinder
TTTGGGAGTGCGATTTTGTTAGGTTCGTTGGAGAATGCGATCGCCCTTTGTGATAAGGGTTGGTTTGGAAGTGCGATCGCTGTTTGTTAGGAGTTGCTTTGGGAGTGCGATTTTGTTAGGTTCGTTGGAGAATGCGATCGCCCTTT

>NC_019751|20|19|4840951-4841096|CRISPRCasFinder
TTTGGGAGTGCGATTTTGTTAGGTTCGTTGGAGAATGCGATCGCCCTTT	GTGATAAGGGTTGGTTTGGAAGTGCGATCGCTGTTTGTTAGGAGTTGC
TTTGGGAGTGCGATTTTGTTAGGTTCGTTGGAGAATGCGATCGCCCTTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015199593.1|4840229_4840721_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015199591.1|4838108_4838372_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015199598.1|4844694_4845471_+|cysteine-hydrolase-family-protein	unknown	unknown	gnl|CDD|238245
NC_019751.1|WP_015199601.1|4847560_4849627_-|S9-family-peptidase	unknown	unknown	gnl|CDD|224684
NC_019751.1|WP_015199596.1|4841945_4842752_-|Rpn-family-recombination-promoting-nuclease/putative-transposase	unknown	unknown	gnl|CDD|371375
NC_019751.1|WP_015199600.1|4845944_4847354_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|214724
NC_019751.1|WP_015199599.1|4845490_4845937_+|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380392
NC_019751.1|WP_015199592.1|4838796_4840074_+|adenosylhomocysteinase	unknown	unknown	gnl|CDD|235488
NC_019751.1|WP_015199594.1|4841185_4841410_+|hypothetical-protein	unknown	unknown	gnl|CDD|223932
NC_019751.1|WP_015199595.1|4841396_4841735_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl|CDD|367091
NC_019751.1|WP_015199602.1|4849912_4850638_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015199584.1|4825032_4825680_+|hypothetical-protein	unknown	unknown	gnl|CDD|269834
NC_019751.1|WP_015199585.1|4827119_4828046_+|DUF11-domain-containing-protein	unknown	unknown	gnl|CDD|273634
NC_019751.1|WP_015199589.1|4836702_4837308_+|Uma2-family-endonuclease	unknown	unknown	gnl|CDD|368559
NC_019751.1|WP_015199590.1|4837432_4837978_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015199597.1|4843036_4844437_-|amidohydrolase	unknown	unknown	gnl|CDD|238623
NC_019751.1|WP_015199583.1|4823886_4824687_+|tryptophan-synthase-subunit-alpha	unknown	unknown	gnl|CDD|178201
NC_019751.1|WP_085953346.1|4834809_4836618_+|hypothetical-protein	unknown	unknown	gnl|CDD|380149
NC_019751.1|WP_015199603.1|4850938_4851994_+|uroporphyrinogen-decarboxylase	unknown	unknown	gnl|CDD|215237
NC_019751.1|WP_015199587.1|4832265_4834590_+|OmpA-family-protein	unknown	unknown	gnl|CDD|143586

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015199594.1|4841185_4841410_+|hypothetical-protein	gnl|CDD|223932	COG0864, NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription].	0.00477751
NC_019751.1|WP_015199596.1|4841945_4842752_-|Rpn-family-recombination-promoting-nuclease/putative-transposase	gnl|CDD|371375	pfam11103, DUF2887, Protein of unknown function (DUF2887). This bacterial family of proteins has no known function. These proteins may be distantly related to the PD(D/E)XK superfamily.	1.87915e-97
NC_019751.1|WP_015199598.1|4844694_4845471_+|cysteine-hydrolase-family-protein	gnl|CDD|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	1.92494e-41
NC_019751.1|WP_015199601.1|4847560_4849627_-|S9-family-peptidase	gnl|CDD|224684	COG1770, PtrB, Protease II [Amino acid transport and metabolism].	0
NC_019751.1|WP_015199600.1|4845944_4847354_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|214724	smart00563, PlsC, Phosphate acyltransferases. Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.	4.98557e-06
NC_019751.1|WP_015199599.1|4845490_4845937_+|cupin-domain-containing-protein	gnl|CDD|380392	cd06987, cupin_MAE_RS03005, Microcystis aeruginosa MAE_RS03005 and related proteins, cupin domain. This family includes bacterial and some eukaryotic proteins homologous to MAE_RS03005, a Microcystis aeruginosa protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	4.81414e-76
NC_019751.1|WP_015199592.1|4838796_4840074_+|adenosylhomocysteinase	gnl|CDD|235488	PRK05476, PRK05476, S-adenosyl-L-homocysteine hydrolase; Provisional.	0
NC_019751.1|WP_015199595.1|4841396_4841735_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl|CDD|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	9.7955e-33
NC_019751.1|WP_015199603.1|4850938_4851994_+|uroporphyrinogen-decarboxylase	gnl|CDD|215237	PLN02433, PLN02433, uroporphyrinogen decarboxylase.	0
NC_019751.1|WP_015199584.1|4825032_4825680_+|hypothetical-protein	gnl|CDD|269834	cd14686, bZIP, Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain. Basic leucine zipper (bZIP) factors comprise one of the most important classes of enhancer-type transcription factors. They act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes including cell survival, learning and memory, lipid metabolism, and cancer progression, among others. They also play important roles in responses to stimuli or stress signals such as cytokines, genotoxic agents, or physiological stresses. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.	0.00809321
NC_019751.1|WP_015199585.1|4827119_4828046_+|DUF11-domain-containing-protein	gnl|CDD|273634	TIGR01451, unnamed_protein_product, conserved repeat domain. This model represents the conserved region of about 53 amino acids shared between regions, usually repeated, of proteins from a small number of phylogenetically distant prokaryotes. Examples include a 132-residue region found repeated in three of the five longest proteins of Bacillus anthracis, a 131-residue repeat in a cell wall-anchored protein of Enterococcus faecalis, and a 120-residue repeat in Methanobacterium thermoautotrophicum. A similar region is found in some Chlamydial outer membrane proteins.	3.29634e-11
NC_019751.1|WP_015199589.1|4836702_4837308_+|Uma2-family-endonuclease	gnl|CDD|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	6.68911e-42
NC_019751.1|WP_015199597.1|4843036_4844437_-|amidohydrolase	gnl|CDD|238623	cd01298, ATZ_TRZ_like, TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are catalyzed by atrazine chlorohydrolase (AtzA), hydroxyatrazine ethylaminohydrolase (AtzB), and N-isopropylammelide N-isopropylaminohydrolase (AtzC). All three enzymes belong to the superfamily of metal dependent hydrolases. AtzA and AtzB, beside other related enzymes are represented in this CD.	3.3027e-135
NC_019751.1|WP_015199583.1|4823886_4824687_+|tryptophan-synthase-subunit-alpha	gnl|CDD|178201	PLN02591, PLN02591, tryptophan synthase.	7.10128e-131
NC_019751.1|WP_085953346.1|4834809_4836618_+|hypothetical-protein	gnl|CDD|380149	NF012181, MSCRAMM_SdrD, MSCRAMM family adhesin SdrD. Features of this protein family include a YSIRK-type signal peptide at the N-terminus and a variable-length C-terminal region of Ser-Asp (SD) repeats followed by an LPXTG motif for surface immobilization by sortase.	7.96199e-23
NC_019751.1|WP_015199587.1|4832265_4834590_+|OmpA-family-protein	gnl|CDD|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	9.35604e-37

Protein sequences

>NC_019751.1|WP_015199593.1|4840229_4840721_-|hypothetical-protein
MESALEQTIALQKKFNIVFREIIFLESKINEKRGFWFFETHVYSKETLFNSEHHSKIDSITEKIGSDVISWNKFGKLTEEGRSVYENMKKEVNDKLEEVGKIIANREPTWWEGIESFFVEFIHKVVINNMPEILIENLAFPLFSKIPILSGVFKRIPKLLGGR
>NC_019751.1|WP_015199592.1|4838796_4840074_+|adenosylhomocysteinase
MTATSPRLKHEVKDLALAPLGRQRIEWAGREMPVLKQIRDRFEKEKPFAGIRISACCHVTTETAHLAIALKAGGADAILIASNPLSTQDDVAASLVVDYGIPVFAIKGEDEATYSRHVQVALDHRPNIIIDDGCDVVATLIQQRPHQIADLIGTTEETTTGIVRLQAMLKDGVLTFPAMNVNDADTKHFFDNRYGTGQSTLDGIIRATNVLLAGKTVVVAGYGWCGKGTAMRASGMGASVIVTEIDPVKGIEAVMDGFRVMPMAQAAALGDIFITVTGNKHVIRSEHFDVMKDGAMVCNSGHFDIEIDLKSLASKASEVKDVRPFTQEYKLKSGKSVVVLGEGRLINLSAAEGHPSAVMDMSFANQAMGAEFLVKNKGKLAAGIHSIPADVDKEIARLKLQAMGITVDTLTQDQIDYSNSWTSGT
>NC_019751.1|WP_015199591.1|4838108_4838372_-|hypothetical-protein
MMKHYILSLNPTAKHEWDRCILRDPLTAKRPDIAKMVAEAIGTNGGSYLVSVNIEIKVLEEASMPQFDQLSLNITEVMEKPQLREAA
>NC_019751.1|WP_015199590.1|4837432_4837978_+|hypothetical-protein
MQNTKFIASLLASAVILPLFTIGGENTATAQRPVSLLRAKCVNSGLGSAREEDMNVSIGRGVYSSRFYLGPGYRSAAITCKIQPDNNQPIFQTLNLGFGMRDNDNRSASVNVVIYVDGKQVETRTISPSKQADVTIDVTNAANVAIEANCSSEKEYCDRVYFYNASLQRPAKQQPAPAEKK
>NC_019751.1|WP_015199589.1|4836702_4837308_+|Uma2-family-endonuclease
MTTQLPIEIEITPIELKFHPVISINDDQLFDFCQLNRDCRIERKANGEIIIMSPTGSETDQRNFDLIVQLGIWTKQDGTGVGFGSSGGFTLPSGAVRSPDAAWIKKTNWEAIPLEKRQKFAPICPEFVIELRSASDSLKVLKNKMEEYIENGTLLGWLIDRVQRKVYVYRPHTVVEELENPTTLSGEDILPGFALDLNPIW
>NC_019751.1|WP_085953346.1|4834809_4836618_+|hypothetical-protein
MFAAPQVAGIGFNQENKVLAQTQLSCPAGTIPATFNWTPSNNLADFLRQSLNAEGVGVRFEFTESTSGVIDTEESRILNSVYGGLPAPNLFFNIGPQKTPAPGGATLNITFSQPVTLASPLILMDIDRNGERDLGFIYQDRVTVTAFNNGSPVSVNTRTLGSPSTVRLTGNLAEGINENSFPDRSDGNIEVVPSGAVSQIRILYEPGQEYGTPTQDESIGVAKITICAPAGSIGDTVYNDTNSNSTQDNAEVGIGNVPVTLVGAGSDGQFGTGDDFTRTTTTDSNGKYSFTELPGGNYRVTVNTPPSGFTPTQVPNNPVTLTPGQKIDTVDFGFNQRQVGSIGDFVFSDRNRNGVADNGEVGIPNVTLILRNSSNQEIARTTTNSNGIYGFPGIPLGEYTVEAIRPGNNFNPTTRTTLPANLTQNNPNTDTIDFGFQSTGVGAEDSPNIRLLKRITGASRNGQTVTGVNFNTFTSDPNSNNDDSLNDAQRQLIRGVPNLSTPLTSGDEAEYTIYFITEGGENLQNIRFCDLIPQGTTFTNNSLTVNGAGNGGDNGRYLSPLTPVDNFSNICPANNTNGAVLVNLGVLPGGNVGFVRFRVTIN
>NC_019751.1|WP_015199587.1|4832265_4834590_+|OmpA-family-protein
MSRLRKKQKSLPKISSHDQLTLAKGRLGKGFQNWHYYFLPLNISLGFCFVAAAIAQQPTVTPIAIPNIKVVVNSNQDGEVQADNQLTLREAVELVNGTLKPEQLSPAEQAQIQPQTVSGSQIEFNLPSGATVIQLQKQLPDLISPGLTIDGTTQPGYDGTKSATAEIPIPVPVVTITTDKDVLRGLTVTADNITIRGLNIYGFNPEPIKQQLGNLLIYDSNPKPVTLTTPPGDIVIAHRFPPPDVSKQQPPNGNFPFGKKDVPPKNITIENNWLGLTVDEKMPEKTSAFGVYVFNSQGATIRRNRISYNDGSAIITSVRSENTIVTENIIVGNGLAGMPDALRFEGVITKSQVTGNLICANDGAGVYLFKPDGDLLLQNNKITYNGRRLRRAAVYLMGSNHQVLGNEIDNQAGPGVVVSAFPRNDVGKSNVGANNVIRDNKFASLEGLSIDLNTQRNLGVSDFQRGDGANPKRNSQNRRLDTGNGAVNAPEFTTRAFAPSGSTVTIEGKADPGAEVTIYRLSDYQRGKSAIYDIGYGALNQPIVTVNTDKSGNFSTQINNIKVGDAVSAIATDPKYGTSEPAIAAVIGEKGTITSLSATVPSIPIKPPECTSKPPEIPPPEIPPPEVPPEVPPPPITLRVPKNIHFALDKSFVSPASAKVLDQIAEVLQQYPFIVIEIQGHTDPRASDAYNLALGRRRALATRNYLLRKGVKPERMTIRSFGESQLKVPNSTDIVDYARNRRAEIVFKDIRGVEIIIEEQEGDLQIEQRRGGRR
>NC_019751.1|WP_015199585.1|4827119_4828046_+|DUF11-domain-containing-protein
MTSMFLWLRHKSLLFPFFFLSVITYTLSPSFAQTDIRNTARVGADNLPGGRVVDSNPVTLRAGQAALETIKTGDRAAAEPGDTVVYRLAIRNTGNVVARNVSVTDRLPIGLTLINKSVKGSIGNQSIDLTISPASNRSVTITTQQELQPNQILNVVYAVEVTPDAVRGNGINLAQARAGNLGSNQASYRLQIRKGIVSDCATLIGRVFIDKNFDGEQQRNEPGVPNAVIYMDDGNRIITDANGLYSLSNVISGYRSATLDLTSLPGYALAPNKYFIEKNSFSRMVRLAPGSMGRVNFAVTPAFSEERR
>NC_019751.1|WP_015199584.1|4825032_4825680_+|hypothetical-protein
MSESMAFIGGVAVAGLAALVLLRGNPSPIAQSGFTLPSQLPPQVVTPPVIQPGQYGVGQTSPNLLPGDPNSTQLRIDNERVKMQMDNLMRENDRIKAENQQLQFQLQNYNNQAQLNAIRDQSQNQLLQSQQPQTPWWSSGIIWAVGGMALTVGGGIVVAGVSALFSPKQRQSRTVQVIHPYTGPTPPLVPTRRTEFLPPRNEVRRVESPEYDDIY
>NC_019751.1|WP_015199583.1|4823886_4824687_+|tryptophan-synthase-subunit-alpha
MTPISECFANLAQRRECALIPFITAGDPDLETTAKALRLLDDSGADIIELGVPYSDPLADGPVIQAAATRALQRGTTLDRVLEMLTSTIPDVRSPIILFTYYNPILNRGIEQFLEQVKQAGVSGLVVPDLPLEEARGLLEPAAAIGIDVTLLVAPTSSAERIEAIARASQGFIYLVSVTGVTGMRTQIETRVSDILKQIRGYTDKPIGVGFGISQPEHATQVREWGADAVIVGSAVVKRLAEGTPAQGLDAVGEFCHQIKNAIALA
>NC_019751.1|WP_015199594.1|4841185_4841410_+|hypothetical-protein
MNVEKLSISLPASLVGFIENYKLEKGCKSRSQVVEKALELLRNQELEGAYRLASQEVDSAWDVTIVDGLTDETW
>NC_019751.1|WP_015199595.1|4841396_4841735_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MKRGDIFYANLSPAMGSEMDKQRPVLIVSNNANNRASTTITILPLTSNVTRVYPFEVLINSEDSGLSKVSKVQAQQIRTISKERIKSEVVGSLSAELMIAIDTALKLHLGLD
>NC_019751.1|WP_015199596.1|4841945_4842752_-|Rpn-family-recombination-promoting-nuclease/putative-transposase
MKTDTIFYTLLQNLPSVLFELLEQPSTLALRYDFSSVEIKELARRIDGVFLPKSDFLEEPIYFVEVQFQPDEDLYWRLITEAAVYLNQYKPNRTCQVVVLWAKRSFDPGVPLVYQPLFPAGYIRIIYLDELAEVSGSSIGLGIIKLVVAPENEAVQQARSLIEEVKQVDAGNRRNLLELVERMLVYKFSSYSRQELEAMFGLSEWKQTRFYQEVREETRQELKEEVKEETQMENIPRLLKIGLTIEQIAQALELDIEVVQEVVNKQNK
>NC_019751.1|WP_015199597.1|4843036_4844437_-|amidohydrolase
MNFIIQNALVATNDNYTTQDIQIVDKNISVSFASQLETPETVVNGENKLLLPGFINAHTHSSEMWQRGIMSMFPLELWLAELYDFAPLTTEEVYLSALGTAVETLLSGGTTVVDHLVLIPGKELETIATAVRAYKEVGIRAFIAPLIQDESIAAGIPAGDTQQTYEPYFRSTQQTLDIIEDAVKQFHNSDAGINIVVAPTGIQLCSDALFQGCAELSNKYNLCRHSHLLETKAQEKLALEKYGCTAVEHLQRIGYLDYRTSLAHCVHLNDADIEILAETKSTVVHNPLSNLRLGSGIAPVIKYRQAGVNVSFGCDGASSNDSQDLLEAIKIGSILHNVTDLDYQHWITPRDSVKMAALGGAIGLNIGDVLGSLDVGKKADLVLYDLTSLSLLPRTDPIGLLVLGRPTNIVNSAWVDGKQVVADGKVTTIDVDNLRQELFQRSHWQSQRKSKTAKELESHYRAVMGI
>NC_019751.1|WP_015199598.1|4844694_4845471_+|cysteine-hydrolase-family-protein
MDLPLKKLGIAPNAWTVNSEIADITRPPLNPQPVILATETKTLRIDLAKSALLIIDMQNDFCHPDGWLSHIGVDITPARQPIAPLKHLLPLLREVNIPIIWINWGNRPDLLNISAAASHVYNPTGEGIGLGDALPKNGAKVLMKDSWAANVVDELEQLPEDICIDKYRMSGFWDTALDSILKNLGRTTLFFTGVNADQCVMTSLQDAHFLGYDCILLQDCTATTSPEYCWQATLYNVKQCFGFVSDSQAMLKAIDNIY
>NC_019751.1|WP_015199599.1|4845490_4845937_+|cupin-domain-containing-protein
MQIKSCVIPIIKSPQDYQVFRISPDDTNRLAIVFDTANANTSLTCCIEIFDVGGKTPPNRHQWAVEMFFILKGEGVALCDGKSVVIKAGDSLLVPPTGTHMIQNTGSSRLYTLTVMVPNEDFSELIRSGIPVELDAEDLEVLNRGLIV
>NC_019751.1|WP_015199600.1|4845944_4847354_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MPEKIRSTQPPLKFLPPKFNPFIHQLTKLAFPLLLRFRFRPWLPSGISNFETENVVELVKLYQQFQAGKVRFLMAFRHPEVDDPLSMFYLLSRAVPKAAKQHSIFLQKLTHSHFIYDRGMTVWAGDWLGWYFSKLGGMPIRRGKRIDKRALQVARQLFTNSNMPLSIAPEGATNGHSGIVSPLEPGVSQLAFWCIEDLIKENRSEEVFILPITIKYSYPKPPWRKLDWLLTKLERESGLVTISSNNLTNQNKEEIYYQRILKLAEHLVVQMEDFYQRFYHINFEPIEIDSEFEPNTEFIKRLQRLLDKALTVAEQYFSVPPQGTLIDRCRRLEDVGWSYIYREDLADLNTLAPLTKGLADWVAIEADQRMKHMRLVESFIAVSGNYITEKPTFERFAEMTLLMFDLISRLKDNTLPGRPRLGWRQSHISVGKPISVTQRWNKYSESRHSAREEVSNLTQEIYQELKNMI
>NC_019751.1|WP_015199601.1|4847560_4849627_-|S9-family-peptidase
MSPNPNFISPIAKKKPEILELHGDKRIDNYFWMRDIENPEVTAYLEAENDYANAVMKPTEVLQTQLYEEMLSRIKETDLSVPIRKDDYYYYSRTEEGKAYAIHCRKKGSLDAPEEVLIDENQLAEGEDFFSLGIFAVSPNHQILAYSVDTNGSERYQLYFVNLVDHKFYPETIPDTYYSFAWANDNRTVFYTKIDDANRPFQILSHQLGSSAETDILIHHEPDNSYFLSIGKTRSDAYILLNCGSQITSEVYYLDANQPQETFKLFHPRIHGIEYEIDHHGDCFYIVTNEDAINFKLMKTLVSKSAKENWQLVIPHREDVMLSGISIFANHLVIYERKFGLPRARIQNITTGVENDIQFPEPTYAFFEGANPEFHTNILRFTYTSLITPASVFDYNMDTQERELKKETEVVGGYDKTQYRSEMLTATAEDGSQIPISIVYKQNIQKNGINPLFLTGYGSYGYPYPVSFSSSNLPLLERGIVYAIAHIRGGGEIGRKWYENGKFLNKKNTFTDFITCAEYLIEQNWTSPQNLAISGGSAGGLLMGAVINMRPDLFQAVVADVPFVDVISTIIDTSLPLSAIEWEEWGNPNDKIYYDYIKSYSPYDNVEAKAYPHLLITAGLNDPRVKYWEPAKWTAKLRELKTDNNILLLKTNMGAGHGGASGRYESLKELAFEYAFVFQRLGIEIGEQ
>NC_019751.1|WP_015199602.1|4849912_4850638_-|hypothetical-protein
MQTESHDPINAECTIYLIPRSHRRKFFIQFTVMTALGWVVGGVVSIVFDKLVTDKLLSTFTPQLLNLWSNWGSYASLGLFAVIFAADQAIILRKYVSGWLWILTTSCGWLIATQVSTAWINYISSLAESLQRNLLPKEILIIGIVCTGAYIVSGVWMGFTQWIVIRRYTIEAWWWNFLPSIAFFVISLLVWLLSLAYDLFPTIYRDQILGYGEQGLTALTLGIVPAIALCRLKTKGKPTTT
>NC_019751.1|WP_015199603.1|4850938_4851994_+|uroporphyrinogen-decarboxylase
MGISANEPLLLRAARGEVVDRPPVWMMRQAGRYMKAYRDLREKYPSFRERSEIPDVAIEVSLQPWKAFQPDGVILFSDIVTPFPGLGIDMDIAEGKGPIIHAPIRTQAQVDSLIPLNPEESLPFIKTILQALRQEVGNKSTVLGFVGAPWTLAAYVVEGKGSKTYSVIKNMAFSDPTILHQLLTKFADAIATYIRYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQKMVFDKVKQTHPDTPLILLVSGSAGVLERMAKSGADIATVDWSVDMADARIRLGKQMKVQGNLDPGVLFGSKEFIRDRIYDTVRKAGDTGHILNLGHGVLPQTPEENVAFFFETAKQLKLATV

Crispr_ID: NC_019751_21

• CRISPR_ID: NC_019751_21
• CRISPR_location: 5480533-5480634
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_21

Consensus_repeat	Method
AGTTTTGTCATTGCAACGAAAGG	CRISPRCasFinder

spacers of NC_019751_21

>21.1|5480556|56|NC_019751|CRISPRCasFinder
TAGACGCAAAGCGCCTTGTCCCAGACTACCAATCTCACGATCTCTACTAAAACCAG

CRISPR arrays and Neighbor proteins around NC_019751_21

CRISPR arrays

The CRISPR arrays of NC_019751_21

>merge|NC_019751|21|5480533-5480634|CRISPRCasFinder
AGTTTTGTCATTGCAACGAAAGGTAGACGCAAAGCGCCTTGTCCCAGACTACCAATCTCACGATCTCTACTAAAACCAGAGTTTTGTCATTGCAACGAAAGG

>NC_019751|21|20|5480533-5480634|CRISPRCasFinder
AGTTTTGTCATTGCAACGAAAGG	TAGACGCAAAGCGCCTTGTCCCAGACTACCAATCTCACGATCTCTACTAAAACCAG
AGTTTTGTCATTGCAACGAAAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015200079.1|5488192_5489209_+|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl|CDD|129820
NC_019751.1|WP_015200074.1|5484881_5485229_+|DUF760-domain-containing-protein	unknown	unknown	gnl|CDD|368489
NC_019751.1|WP_015200069.1|5479681_5479936_+|Pr2TM-family-membrane-protein	unknown	unknown	unknown
NC_019751.1|WP_015200080.1|5489936_5492141_+|transketolase	unknown	unknown	gnl|CDD|226466
NC_019751.1|WP_041739856.1|5475934_5476639_+|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NC_019751.1|WP_015200062.1|5470850_5473175_+|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl|CDD|349772
NC_019751.1|WP_015200073.1|5482647_5484099_+|phosphoglucosamine-mutase	unknown	unknown	gnl|CDD|237671
NC_019751.1|WP_015200072.1|5481333_5482050_-|heme-oxygenase-(biliverdin-producing)	unknown	unknown	gnl|CDD|227685
NC_019751.1|WP_015200075.1|5485333_5485771_+|8-oxo-dGTP-diphosphatase-MutT	unknown	unknown	gnl|CDD|239517
NC_019751.1|WP_015200078.1|5487111_5488098_+|ADP-ribosylation/crystallin-J1	unknown	unknown	gnl|CDD|377122
NC_019751.1|WP_015200066.1|5476642_5477656_+|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|182669
NC_019751.1|WP_015200071.1|5480980_5481199_+|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015200067.1|5477697_5478927_+|MFS-transporter	unknown	unknown	gnl|CDD|341042
NC_019751.1|WP_015200070.1|5480046_5480358_+|DUF3181-family-protein	unknown	unknown	gnl|CDD|371499
NC_019751.1|WP_085953347.1|5485887_5486292_+|TMEM165/GDT1-family-protein	unknown	unknown	gnl|CDD|225030
NC_019751.1|WP_015200063.1|5473455_5474772_+|lipopolysaccharide-biosynthesis-protein	unknown	unknown	gnl|CDD|240532
NC_019751.1|WP_015200077.1|5486367_5486853_+|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl|CDD|223854
NC_019751.1|WP_015200061.1|5468444_5469767_-|O-antigen-ligase-family-protein	unknown	unknown	gnl|CDD|225844
NC_019751.1|WP_015200068.1|5479130_5479637_+|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl|CDD|236483
NC_019751.1|WP_015200064.1|5474952_5475912_-|hypothetical-protein	unknown	unknown	gnl|CDD|379138

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015200079.1|5488192_5489209_+|tRNA-dihydrouridine-synthase-DusB	gnl|CDD|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	1.43479e-151
NC_019751.1|WP_015200074.1|5484881_5485229_+|DUF760-domain-containing-protein	gnl|CDD|368489	pfam05542, DUF760, Protein of unknown function (DUF760). This family contains several uncharacterized plant proteins.	2.03074e-39
NC_019751.1|WP_015200080.1|5489936_5492141_+|transketolase	gnl|CDD|226466	COG3957, COG3957, Phosphoketolase [Carbohydrate transport and metabolism].	0
NC_019751.1|WP_041739856.1|5475934_5476639_+|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.74309e-32
NC_019751.1|WP_015200062.1|5470850_5473175_+|polysaccharide-biosynthesis-tyrosine-autokinase	gnl|CDD|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	3.09669e-53
NC_019751.1|WP_015200073.1|5482647_5484099_+|phosphoglucosamine-mutase	gnl|CDD|237671	PRK14317, glmM, phosphoglucosamine mutase; Provisional.	0
NC_019751.1|WP_015200072.1|5481333_5482050_-|heme-oxygenase-(biliverdin-producing)	gnl|CDD|227685	COG5398, COG5398, Heme oxygenase [Inorganic ion transport and metabolism].	2.63314e-127
NC_019751.1|WP_015200075.1|5485333_5485771_+|8-oxo-dGTP-diphosphatase-MutT	gnl|CDD|239517	cd03425, MutT_pyrophosphohydrolase, The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). This enzyme requires two divalent cations for activity; one coordinates the phosphoryl groups of the NTP/dNTP substrate, and the other coordinates to the enzyme. It also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as metal binding and catalytic site. MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides.	5.47837e-56
NC_019751.1|WP_015200078.1|5487111_5488098_+|ADP-ribosylation/crystallin-J1	gnl|CDD|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	7.44332e-43
NC_019751.1|WP_015200066.1|5476642_5477656_+|glycosyltransferase-family-2-protein	gnl|CDD|182669	PRK10714, PRK10714, undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional.	5.85255e-78
NC_019751.1|WP_015200067.1|5477697_5478927_+|MFS-transporter	gnl|CDD|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	9.93506e-85
NC_019751.1|WP_015200070.1|5480046_5480358_+|DUF3181-family-protein	gnl|CDD|371499	pfam11378, DUF3181, Protein of unknown function (DUF3181). This family of proteins has no known function.	1.39419e-49
NC_019751.1|WP_085953347.1|5485887_5486292_+|TMEM165/GDT1-family-protein	gnl|CDD|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	2.09304e-29
NC_019751.1|WP_015200063.1|5473455_5474772_+|lipopolysaccharide-biosynthesis-protein	gnl|CDD|240532	cd13127, MATE_tuaB_like, Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins. This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	2.97855e-81
NC_019751.1|WP_015200077.1|5486367_5486853_+|DNA-starvation/stationary-phase-protection-protein	gnl|CDD|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	4.08827e-74
NC_019751.1|WP_015200061.1|5468444_5469767_-|O-antigen-ligase-family-protein	gnl|CDD|225844	COG3307, RfaL, Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane].	7.48709e-17
NC_019751.1|WP_015200068.1|5479130_5479637_+|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl|CDD|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	4.43879e-95
NC_019751.1|WP_015200064.1|5474952_5475912_-|hypothetical-protein	gnl|CDD|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	9.22872e-19

Protein sequences

>NC_019751.1|WP_015200070.1|5480046_5480358_+|DUF3181-family-protein
MAATNTTETIEALAAEIGDNIYIDIAKWHLYLRDAKIHTSVAQQLYPLIASNKTINEDDVTKIIKSVTVKIGGGRNEISLIDLLPLQCQVSIVDILEKFQRDM
>NC_019751.1|WP_015200069.1|5479681_5479936_+|Pr2TM-family-membrane-protein
MPPRWSRIPTREDPEYRKLDDRMTFAVHVAGFAAVNSGMWFFHIFLKTDWQWLPWVTLSWLGILVSHLIYISAIADYSETPKST
>NC_019751.1|WP_015200068.1|5479130_5479637_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MQDNFSQSSQSLTHLDIQGQAQMVDVSQKATSIRTAVAVANVRMSQETFTTIEAGNAPKGDVLGTARIAGIMAAKQTANLIPLCHPLPLQKVEVQIIPQPELPGYQIEATVKIKAETGVEMEALTAVSVAALTLYDMAKALEKSIQIESIHLVSKTGGKSGDYLLGKS
>NC_019751.1|WP_015200067.1|5477697_5478927_+|MFS-transporter
MSAFNDIDPRLRQNLLTLFTAGLFFWSSMASLLPTLPLYVEDIGASKQQIGVVMGSFAIGLLLCRPQLGQLADKRSRKLVLIIGALVAAIAPLGYAVVKSIPLLMALRAFHGISLAAFTTGYSTLVTDLAPSEKRGEIVGYMSLVNPIGMAIGPALGGYLQSEYGYLPLFLFSTISALLCLTCVYQVFCPVVAKKTYATGEDISLWKILLSPRIRIPTLVMFLVGLAFGTLSTFVPLFIKSIKIDLNAGLFYSTAAITSFSSRLVMGRISDRIGRGLFVTIGIVCYSISMFLLWQADSKASFLLAALIEGVGGGLMIPSIVTMMADRSQPQERGRVFALCVGGFDVGIAIAGPILGSVAEKLGYRDMFGFASFLTFVAIFIFMTQSSKSIRTSFNFALGRGKDVYAITE
>NC_019751.1|WP_015200066.1|5476642_5477656_+|glycosyltransferase-family-2-protein
MGSGLISERIEGMDNIISLPIPDVSVVVPIKDEVESLPHLLDAIASTLQGCNLSYEIICVDDGSVDGSPQLLKEKAENRSDLKSVILRRNYGQTAAMAAGFNHATGKVIVTLDADLQNDPADIPMLLSKLDEGYDMVSGWRQKRQDKALTRLLPSKIANWLIRRITGVRIHDYGCSLKAYRAELVADMNLYGELHRFLPALAYIEGARIAEMPVRHHARKFGQSKYGLSRTFRVMMDLLTIAFMKTFLTRPMHVFGLLGLSSIFSGGAIGLYLTFVKLVFHEDIGDRPLLILAVLLLVTGVQLFCFGLLAEVLMRTYHESQGKPIYRVREVITKNIN
>NC_019751.1|WP_041739856.1|5475934_5476639_+|C40-family-peptidase
MSSNIPSQIQNLTSGEYECLANLNIYDSPECNRLATQAAMGRHLTVTSNDADTAVEVCLCEDNYSGWVSHQDFSLLKLTLHPYRGTLSPKLTDTVSQAQRERAIAFTHDAMKQANYYLWGGTVAPNYDCSGLIQAAFVSVGIWLPRDAYQQEDFTESISISQLNPGDLVFFGTPQKATHVGLYLGDDRYIHSSGKEMGRNGIGIDVLSEHGDAVSRSYYQILRGAGRIIKGLEV
>NC_019751.1|WP_015200064.1|5474952_5475912_-|hypothetical-protein
MNFFSQNEQLEQVGNRVLEATWAEFPTLKSNQIALTWIVYDPPVLVNTGGALTPDAFWNHPVRGFNYRGDERVYPASVVKLFYLVAIHEWVEKGMTQPFPELDRAIRDMIFDSSNDATSLVVDILSGTTSGPELSPAPFETWKYQRNIVNRYYQSLGWKELAQINVCQKTWGDGPYGREMSFYGKMFENRNMLTTNAAARLLHSIIGGVAVSSMRSQTMMKTLKRTLNPQALPQDVEEDQITGFLGAGIPQTSQIWSKAGWTNQVRHDVAYIEIPDLRPYLLAVFTEGKENAKNRQILPFISQQITTAVRHFDVSKEAG
>NC_019751.1|WP_015200063.1|5473455_5474772_+|lipopolysaccharide-biosynthesis-protein
MDVIKQLISKIQKELSSQFVRNLGWLGLAEIIYRIFRVGVVVIFSRFLTRRDYGLGAILFTVRDYALTFTNVGIGAKIIQADEAELDALCDSAYWLNWVVFTALFVIQTALSFPVAWLTNSPEIVLPIVVAGIPYLIWPIVGVQKTLLQRENKFKVIALTDSLQFCVASVISAIFAVSGMGVWVFALPGVLVAPLELIVYLNQHPWRPQRKFTTENWDKIFIFGRNIFGVGLLRTSINNLDNIIIATFLGVESLGNYSWAFNSGLGISLSIIKAINSAILPHLCAVSSELEALKQRYFKSLKTISLLIIPLVLFQATLAPFYIPLIFGQQWADAVPLYVLICLSAIPRPFGDAASQLLVAIGKPNLDLRWNGIFTVIFAICLVIGVRWRDIGVATAVFGAHAVFIPIFVVVATGYVFRQVGGGGKGVGSRKQGAREKG
>NC_019751.1|WP_015200062.1|5470850_5473175_+|polysaccharide-biosynthesis-tyrosine-autokinase
MPIKEESLQHSHNQNPLPNPLMRDATWWKRKSDVDEESSASLSPIFGILRRRIGVIAGIAMVTATTAAIWAASQTAKYEGRFQILVEPLKTSDSELLKLLSQTLQQNVNEITKQNTTALDYNALMEVLKSPKLIDPVVQELLPKYPNTTYDHMVGGDVPSGKVAPGRLGTLYITRLTKGKDESRVIEVRYRDLDPEKVEIVLDRVSQAYRKYSIEQQQTNLRQGMRFIEQQIPKIQLRVNTLQGQMQLFQQHYGLYNPQLQSEQLLKRLDDAKTQRLEVERKLAEARSLYGSLQNQLGMQQNAAIAASALSESPQYQQILTRIREVEAKIATESVKYNEASPIMQDLREQREKLLPLLNQEQRLALGNNNNGEPLPSQVGTYQNSIRRELTQQLANTTNQVQSLTANLQTLVQSEAQMSEQIRQYPVVARQHTNLQRDLQVSTDTLNQLLAKQEALRVDNAQQDVPWELIMPPTLPRDKKGDVVPITPSPTSTAMMGGIGGLLLGALAAFAIENRQNVFYDPEDAKRAGKLPLLGSIPYYRDIHKPAIATNVARLQEQLEQGSKSQVKFSAQAEKEALFAQSFCSIYNRIQAYSVESQVRSITVTSTAGKEGKSTVALQLALIAAQAGQRVLLVDANFRHPQLHESVGLVNTKGLSEILGDGLDLNDVIGQVPREENLFIVTAGQLTQNSSKLLASEKMREFIERSHNEFNLVIYDAPNILGRVDTNILTTHTDGIVLVVGLGKTLRPNLKKLVEELKATRTTVLGMVTNTLVS
>NC_019751.1|WP_015200061.1|5468444_5469767_-|O-antigen-ligase-family-protein
MPGFLILLEKVFVVISLFLSTSALIPILVETEESAIAAADPYTPILFMGVYAVTGVLIFQHWKNFLWIARKDIWLWLLMGIAIASIAWTIAPDITPRRSLLLLGTSLFGAYMAVRYSIRQQLQLLGWAFALLIGLSFVFAIALPNYGLMTFQEGGIHAGAWRGVFSHKNLLGRSMVLSSMIFMFIIASKSVTPKYRWLPWLGYTLSFALIVLSSSKTAIVSFFMLGIIFQLYRSWRLNYSRLIPFAIAFILIFGTTITLIIDNLPLITSAVGRDLTLTGRTDIWMAMLDKISERPFLGYGLNGFWRDWDNEATAFMWRILGWECPYGHNGFMDLFAELGIFGLVSFMISYGTTFFRSISWLRKTKSAEGIWSAMYLTFLLIYNISESTLLTNNSIFWILYTSATFSIFAEYERLQDEQYMNAVYEAQLMELEIFNEQNLN
>NC_019751.1|WP_015200071.1|5480980_5481199_+|hypothetical-protein
MLLQVKETGHLVKISEVVQLIDPTVEEIHGREQAGEEEQDVAAYHKKNLVFPSGETLPRCWVDANYRDTEVN
>NC_019751.1|WP_015200072.1|5481333_5482050_-|heme-oxygenase-(biliverdin-producing)
MSSNLASKLRIGTKKAHTMAENVGFVKCFLKGVVEKTSYRKLVANFYFVYSAMEEEMDKHKNHPIVGKINFPQLNRKQSLEEDLTYYYGANWRDQIKVSPAGAAYVERIRKISATAPELLISHSYTRYMGDLSGGQILKGIAQNAMNLSDGDGTAFYEFPEISDEKAFKANYRAALDEMPLDEATCDRIVEEANDAFGVNMKMFQELEGNLVKAIGQMLFNTLTRRRTRGSTELATAE
>NC_019751.1|WP_015200073.1|5482647_5484099_+|phosphoglucosamine-mutase
MVSFATRTQNGISGVSTIEKATELMVGGVSLPATALFGTDGIRGKVGEILTAPLALQIGFWTGIVLTNHATNLGPVILGQDSRNSSDMLAMALSAGLTAAGVEVWYLGLCPTPCVAHLTSISQAVGGVMISASHNPPEDNGIKVFGANGNKLPQALQLEIEAGLRGISPLGIIQANPGRHYTRPELVADYADSLKKPLQNRLNLQGMKVVLDLAWGAAVGLAPSVFKSMGAEVICLHNKANGDRINVNCGSTHLELLQTTVLENDADFGFGFDGDADRVLAVDNLGRKVDGDYILYLWGSDLKAKQQLPEDLIISTVMANLGFERAWKQIGGNLTRTAVGDQYVQAEMMKTGATLGGEQSGHILCSHYGITGDGLLTALHIAALVKESGVSLGELIDSSFQTYPQILKNVRVEDRNRRLAWEKCEPVMNAIALAEKAMGEAGRILVRASGTEPVIRVMVEAEEIDMVNEWTNTLVAVVQKHLA
>NC_019751.1|WP_015200074.1|5484881_5485229_+|DUF760-domain-containing-protein
MSNHPNRVSEFFNSDSETGNLLWQYVKSLSPETVTQLSKPTSNEVFQVMERNIVGLLGHLPSEHFGVTITTNRENLGRLLASAMISGYFLRNAEQRMDFEVALQGSESEEDTQEL
>NC_019751.1|WP_015200075.1|5485333_5485771_+|8-oxo-dGTP-diphosphatase-MutT
MNQNIDNIPHKIIGVAVIWNDQKQVLIDRRLPKGDMAGLWEFPGGKIEAGETIKDCIQREIKEELGIEIEVRKHLVTIDHTYPNFRITLTVHHCCHLAGIPQTIECEEVRWVDLEDLDNFEFPAANQEIIKALRDGEFRGTYEKN
>NC_019751.1|WP_085953347.1|5485887_5486292_+|TMEM165/GDT1-family-protein
MGLPQSQSHSELNPQAVNLTSSVVATQEHSSSVVSGVSRKSESIFVTFGTTFVTIFLAEIGDKTQLSTLLMSAQSHNPWVVFLGSAAALITTSFLGVVLGSWVSTKLSPKTVEKSAGVMLLLISIMLFWDVINN
>NC_019751.1|WP_015200077.1|5486367_5486853_+|DNA-starvation/stationary-phase-protection-protein
MQTQASNVNIGIDDANRAKIAEGLSRMLADTYTLYLKTHNFHWNVTGPMFQTLHLMFETQYNELALAVDLIAERIRSLGYPAPGTYSEYAKLSSIPETAGVPKAKEMIRLLVEGQEAVVRTARSIFPILEEVNDEPTADLLTQRMQVHEKTAWMLRSLLEE
>NC_019751.1|WP_015200078.1|5487111_5488098_+|ADP-ribosylation/crystallin-J1
MRRASGCLFGLAFGDALGAKTEFLSVEEIIRRFPPQGPKELEDNPALVTDDTQMTLAVGEALIAVASGEYTANTLEPVLRKAFVDWCNSPDNNRAPGMTCLSACEKLETGIPWYEATVAESKGCGANMRVAPVAFLGVEQQGAIAQFQAALTHGHPTALVGSDLTARAIHFLIQGCQIKELPAQLRNYAYEQRTVYHHDWLGNLWERPYTKTPEEFISRGWDECLGILDRLDAALINPDYDTDPCLATGAGWIAEEAFGTGLLCFLLYPEEPVKALQRAAVTSGDSDSIACLTGAFAGTYLGMSVWSEDWISKIEYRDRLERLSKFWD
>NC_019751.1|WP_015200079.1|5488192_5489209_+|tRNA-dihydrouridine-synthase-DusB
MLSPTLQTRLSTPLKIGTLQLKSRVFQSPLSGVTDLVFRRLVRRYAPESMLYTEMVHASNLQYVKEIPKIMEVDPNERPISIQLFDCRPHFLAEAAQKAVEEGADTVDINMGCPVNKITKKGGGSSLLRQPELAETIVREVVKAVDVPVTIKTRIGWDDEEITILDFAKRMEDAGAKMITVHARTRAQGYNGSARWEWIGKVKKILEIPVIANGDIFSVESAVDCLEVTGADGVMCSRGTLGYPFLVGEIDYFLKHGEYLPPPTAIERLTCAKEHLQALYEYKGDRGIQQARKHMAWYAKGFVGAAELRGDLSKVENVQQGVEMIDLVIEKLETGIAF
>NC_019751.1|WP_015200080.1|5489936_5492141_+|transketolase
MTATTPKPTSAYPDFCEGIQYFGESLPEFAKYGKESAISGVAVNSSDDAAVYQTILYADALRYLTLQVTGSKASGHPGGFASQAEAYAALVMLGYKNIITEVGHHAPGFYSAMFLDRSLEDMGITNVQQLRDRFREQHGLLGHLSGYIPGILAPAGPLGQGQHFAMSAALLHRDKLFPFTVGDGGLGEPYIMSSMGHFHTAYPEVTNFLPVLVWNGFSQEHHSMVSTKTNAEMIQYWQGNGFDEVILVDAKDFDDQNQPGDYVDGTAFSFTKRMEFTKAILTEVDRAAKSALGGKLTVFIIKQLKGAGVHARGAKSHNLYPKDTLDAPHIADTLKAIALSPEAWQLVRSNLEKAGGGSASKTAVTEFELAIADIGTLPLEEYAVGGEAKVATTAMGRLVGIVGQKDKQFIVTNADGNEASGIANINQALKINHPVKDDLYNQAPGGQVYEPLSEDACAGLAAGLALMGARTLWCSYESFAINGLPIWQTVIQAMAELRRQTPSTITLYTAGALEQGRNGWTHQRPEIEAYFAAMMRNGNVFPLFPCDANSIQVCYDWALTTKNKGIVITASKSPLAIRTTFAQTKEGLENGAVVLQETPGNKMVVFAVIGDITLLPAYEAAKKLQEQGVGSRIVSIINPRRLYRADDVAWSTCSEADGGFLDDAKFNQIFGGDALIGVTGGAAAMLEPIMLRSTSPRDTFAWKRGETTASAGELMAFNGITADALVKRGISLVG

Crispr_ID: NC_019751_22

• CRISPR_ID: NC_019751_22
• CRISPR_location: 6352584-6352690
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019751_22

Consensus_repeat	Method
CGTGCGGGAAATCGTCCCCAGGAAATTGC	CRISPRCasFinder

spacers of NC_019751_22

>22.1|6352613|49|NC_019751|CRISPRCasFinder
CCAAGTGCGATCGCGTTTAGCCCAAACTGAGGCACAATTGGCAGCAGCG

CRISPR arrays and Neighbor proteins around NC_019751_22

CRISPR arrays

The CRISPR arrays of NC_019751_22

>merge|NC_019751|22|6352584-6352690|CRISPRCasFinder
CGTGCGGGAAATCGTCCCCAGGAAATTGCCCAAGTGCGATCGCGTTTAGCCCAAACTGAGGCACAATTGGCAGCAGCGCGTGCGGGAAATCGTCCCCAAGAAATTGC

>NC_019751|22|21|6352584-6352690|CRISPRCasFinder
CGTGCGGGAAATCGTCCCCAGGAAATTGC	CCAAGTGCGATCGCGTTTAGCCCAAACTGAGGCACAATTGGCAGCAGCG
CGTGCGGGAAATCGTCCCCAAGAAATTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019751.1|WP_015200765.1|6349729_6350233_-|hypothetical-protein	unknown	unknown	gnl|CDD|378182
NC_019751.1|WP_015200771.1|6355915_6356455_+|SH3-domain-containing-protein	unknown	unknown	gnl|CDD|377965
NC_019751.1|WP_015200774.1|6359206_6361645_-|penicillin-binding-protein-1A	unknown	unknown	gnl|CDD|273955
NC_019751.1|WP_015200758.1|6341017_6342181_-|GuaB3-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl|CDD|236322
NC_019751.1|WP_015200777.1|6363262_6367126_-|hypothetical-protein	unknown	unknown	unknown
NC_019751.1|WP_015200772.1|6356563_6358093_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NC_019751.1|WP_041740929.1|6342751_6345133_+|endonuclease-MutS2	unknown	unknown	gnl|CDD|234750
NC_019751.1|WP_015200762.1|6348613_6349270_+|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl|CDD|223881
NC_019751.1|WP_015200773.1|6358230_6359058_+|deoxyribodipyrimidine-photo-lyase	unknown	unknown	gnl|CDD|223492
NC_019751.1|WP_015200761.1|6346561_6348298_-|TonB-family-protein	unknown	unknown	gnl|CDD|367555
NC_019751.1|WP_015200760.1|6345427_6346141_-|rubrerythrin-family-protein	unknown	unknown	gnl|CDD|224508
NC_019751.1|WP_015200775.1|6361975_6362473_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl|CDD|238269
NC_019751.1|WP_015200757.1|6339617_6339941_-|thioredoxin	unknown	unknown	gnl|CDD|200072
NC_019751.1|WP_041740932.1|6350432_6351542_+|S-(hydroxymethyl)glutathione-dehydrogenase/class-III-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|176260
NC_019751.1|WP_015200769.1|6353716_6354934_+|FtsX-like-permease-family-protein	unknown	unknown	gnl|CDD|182528
NC_019751.1|WP_041739983.1|6362560_6363112_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239516
NC_019751.1|WP_015200756.1|6338280_6339396_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NC_019751.1|WP_015200763.1|6349253_6349655_+|biopolymer-transporter-ExbD	unknown	unknown	gnl|CDD|223917
NC_019751.1|WP_015200778.1|6367277_6367865_+|Uma2-family-endonuclease	unknown	unknown	gnl|CDD|99749
NC_019751.1|WP_015200770.1|6354998_6355814_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019751.1|WP_015200765.1|6349729_6350233_-|hypothetical-protein	gnl|CDD|378182	pfam09413, DUF2007, Putative prokaryotic signal transducing protein. This is a family of putative prokaryotic signal transducing proteins of Pii-type.	0.0055585
NC_019751.1|WP_015200771.1|6355915_6356455_+|SH3-domain-containing-protein	gnl|CDD|377965	pfam08239, SH3_3, Bacterial SH3 domain.	0.000109541
NC_019751.1|WP_015200774.1|6359206_6361645_-|penicillin-binding-protein-1A	gnl|CDD|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NC_019751.1|WP_015200758.1|6341017_6342181_-|GuaB3-family-IMP-dehydrogenase-related-protein	gnl|CDD|236322	PRK08649, PRK08649, GuaB3 family IMP dehydrogenase-related protein.	0
NC_019751.1|WP_015200772.1|6356563_6358093_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.8818e-25
NC_019751.1|WP_041740929.1|6342751_6345133_+|endonuclease-MutS2	gnl|CDD|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	0
NC_019751.1|WP_015200762.1|6348613_6349270_+|MotA/TolQ/ExbB-proton-channel-family-protein	gnl|CDD|223881	COG0811, TolQ, Biopolymer transport proteins [Intracellular trafficking and secretion].	1.59911e-46
NC_019751.1|WP_015200773.1|6358230_6359058_+|deoxyribodipyrimidine-photo-lyase	gnl|CDD|223492	COG0415, PhrB, Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair].	4.41221e-57
NC_019751.1|WP_015200761.1|6346561_6348298_-|TonB-family-protein	gnl|CDD|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	1.00268e-12
NC_019751.1|WP_015200760.1|6345427_6346141_-|rubrerythrin-family-protein	gnl|CDD|224508	COG1592, COG1592, Rubrerythrin [Energy production and conversion].	7.43792e-44
NC_019751.1|WP_015200775.1|6361975_6362473_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl|CDD|238269	cd00483, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.	1.55777e-60
NC_019751.1|WP_015200757.1|6339617_6339941_-|thioredoxin	gnl|CDD|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	1.23224e-54
NC_019751.1|WP_041740932.1|6350432_6351542_+|S-(hydroxymethyl)glutathione-dehydrogenase/class-III-alcohol-dehydrogenase	gnl|CDD|176260	cd08300, alcohol_DH_class_III, class III alcohol dehydrogenases. Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding.	0
NC_019751.1|WP_015200769.1|6353716_6354934_+|FtsX-like-permease-family-protein	gnl|CDD|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	1.02947e-73
NC_019751.1|WP_041739983.1|6362560_6363112_+|NUDIX-hydrolase	gnl|CDD|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	1.87301e-49
NC_019751.1|WP_015200756.1|6338280_6339396_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	5.94466e-73
NC_019751.1|WP_015200763.1|6349253_6349655_+|biopolymer-transporter-ExbD	gnl|CDD|223917	COG0848, ExbD, Biopolymer transport protein [Intracellular trafficking and secretion].	1.48305e-33
NC_019751.1|WP_015200778.1|6367277_6367865_+|Uma2-family-endonuclease	gnl|CDD|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	3.05133e-14
NC_019751.1|WP_015200770.1|6354998_6355814_+|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	9.66774e-117

Protein sequences

>NC_019751.1|WP_041740932.1|6350432_6351542_+|S-(hydroxymethyl)glutathione-dehydrogenase/class-III-alcohol-dehydrogenase
MKVKAAIAYQAGKPLTIETVDLAPPRSREVLVEIKASGVCHTDAYTLSGKDPEGLFPAILGHEGAGVVVEVGKDVRSLRVGDRVIPLYTPECRECAYCLSFKTNLCQAIRVTQGRGVMPDGTSRFSLNGEMIHHYMGTSTFANYTILPEIALAKIRDDAPFEKVCYIGCGVTTGIGAVINTAKVEPGANVVVFGLGGIGLNVIQAAKMVGANMIIGVDINPGKKVLAEKFGMTHFVNPQEVEGDLVPYLVDLTKGGADYSFECIGNVKLMRQALECCHKGWGQSIIIGVAAAGEEISTRPFQLVTGRVWKGSAFGGARGRTDVPKIVDWYMEGKINIDDLITHVMPIEKINDAFDLMHRGESIRSVVTF
>NC_019751.1|WP_015200765.1|6349729_6350233_-|hypothetical-protein
MNQKLITIATFPNSVEAALSKQLLEGVGIPAFVINADIADVAWYYTIMVGWIKLKVRECDVENAVDILTATSVELDEDISQEMPISSEESEFNYISKPDKIIDFAFRASIIGLFSIPFLLHLYSLALLIYLLFTGWHVSANTQLKALATFLINISVMRFTWLIFSNS
>NC_019751.1|WP_015200763.1|6349253_6349655_+|biopolymer-transporter-ExbD
MRLPDEPDIPAQINIVPMIDVIFAILTFFIMSTLFLTRQEGLPVNLPKASTSQQSQVATKITVTVDAEGQVSLNKNPTTVDVIAEQVRRLMGTNSEAVVIINADEAVGHGKVVAVMDQVRQVEGAKLAIATQK
>NC_019751.1|WP_015200762.1|6348613_6349270_+|MotA/TolQ/ExbB-proton-channel-family-protein
MAISKLFADGGVVMYPLLAFSVVAIALIIERVSFWYRINTRQSKVAREVLNLYRLENVVGALDKLQKNVDLPIARVFLSALELEEATPEEFRLALESEAQAEIPILKRFNNIFETIISLAPLLGLLGTVLGLIASFESIDLSNGAGAGAARVTGGISEALVSTASGLVVAIFVLMFANTFRGFYQRQIAFLQEYGGQLELLYRRRYERGGEKSYAATR
>NC_019751.1|WP_015200761.1|6346561_6348298_-|TonB-family-protein
MSFSSIAIGQREKEVKALKTFLVGSTVSSLVLHIVVLAVGVGSFWVRNPQIEDEKPVELTFVEPEIKETSIPEDNKLGASKVLTSGGGGNEGGSSGGSEGGSSTQISSQVQSQQKIAVQTPPKLSAPIPQNIEKPVTPEKFTPAQKPAENPQRQSSRSIQPQKDDPVTSKEPKQVVNNTPVNPATDNQESSNNLRGLLSQFRDSRVIQATSGNSSTVTESGGTGNSSTGSGIGNGNGTGTGNGNGTGFGSGNGTGTGNGNGVGFGSGNGTGTGNGNGVGFGSGNGTGTGKTERRKREIAVAPTEPKIPTQKPENNGGSGGSADGRAACSDCKVKYSEGARRRKAEGRIQVAVDTDKDGNITNIRLASSSGDRELDEEHLRQAQNWKLKPSQAGRQGVNIATEYSIQGSRRNRQVRERQQQREERERQRQVAAASSNSQETPRRRRRNTESSSQTASGNEESRSTRLNQRLRRRTETSVSRNDNETQQSTRRERSSEDSSVGSRLRRRSSENNASEVTPRRRVQVTSENYQRTQQAPTRRKKREFNRSNQSSDSGSRLRSVLRRSRESAPAPSTGKEAE
>NC_019751.1|WP_015200760.1|6345427_6346141_-|rubrerythrin-family-protein
MNLENSNTAKNLEDAFGGESMANRKYLFFSEVVKQLGMADLAKLFRETANQETEHAFAHFRLMHPELVVGDATKLTDSEKKAIASRCLELAIEGETYEYQVMYPGFAEQARGDRDDGAVAEFEVQEKESREHAQIFRKAAHNFGLLTHIENHHAQQYGEALKALDGTAPVVKMQTGNPATQKWICRQCSMIYDPVVGDVDSGIAAGTAFADIPEDWRCPICGATKKTFVVYEEAAAA
>NC_019751.1|WP_041740929.1|6342751_6345133_+|endonuclease-MutS2
MIQSETLELLEWSRLCQHLANFAATKLGAIASRNLQIPTSQAQSENLLAQTQEIYKLESRISPGLSFEGIQDIGDAIERAALQGILAGEELLAIATTLAGTRNLRRIIDNQEDLPILLDLVADLRTYPEIEQEIHRCVDERGQIADRASQKLGDIRAELRKSRSQIIQKLQNILQVKSNAVQENVITQRGDRYVIPVKASHKDVIHGIVHDTSTSGVTLYIEPNSVVPMGNQLRQLIRKEEIEEEVIRRQLTAQVADIKDDLERLLAIVTTLDLATAKSRYSFWLKANPPRFVDREANETITLRKLRHPLLEWQHQHEQGHEVIPVDLVIQPETRVVTITGPNTGGKTVTLKTLALAALMAKVGLFVPAREPVELPWFEQVLADIGDEQSLQQSLSTFSGHIRRISRILNAITGDTVTPSLVLLDEVGAGTDPVEGSALAIALLHHLANHVLLTMASTHFGELKALKYQDERFENASVEFDDATLSPTYKLLWGIPGRSNALAIAQRLGLSVDVIEAAKQQMGGANDEVNEVIAGLEAQRRRQETKASEAQNLLHQAEKLYKEVSAKATNLEEREQALKASQEVAVQNAIAQAKGEIAKVIKGLQKGKPTAQEAQQATNTLNQISTQFIPKAAPKAPIGFIPKTGDRIRITKIGQTAEVITPPNSDGELNVRFGIMKMTVKLEDIESLDGKKPEPIAKPQNRTPPPPVTPPPPAIRTSQNTIDLRGKRVADSEIILDQAISTAAGQIWIIHGHGTGKLREGVHAYLKQHPRISHTEPAAQADGGTGVTIAHIK
>NC_019751.1|WP_015200758.1|6341017_6342181_-|GuaB3-family-IMP-dehydrogenase-related-protein
MDIQIGRGKTARRAYGIDEIALVPGNRTLDPSLADTKWSIGNIEREIPIIASAMDGVVDVRMAVRLSELGALGVLNLEGIQTRYDNPEPILDRIAAVGKTEFVSLMQELYAEPIKPELIELRIQEIKQQGGIAAVSATPAAASKFGGVIAKAGADMIFIQATVVSTAHLSPESIVPLDLAKFCEEMPMPVILGNCVTYDVTLNLMKAGAAAVMVGIGPGAACTSRGVLGVGVPQATAIADCSAARDDFFRETGKYVPIVADGGLITGGDICKCIACGADGVMIGSPFARAAEAPGRGFHWGMATPSPVLPRGTRINVGTTGTVEQILRGPAGLDDGTHNLLGSLKTSMGTLGAKNIKEMQQVEVVIAPSLLTEGKVYQKAQQLGMGK
>NC_019751.1|WP_015200757.1|6339617_6339941_-|thioredoxin
MSAAEQVTDSSFKEQVIDSEVPVLVDFWAPWCGPCRMVAPVVDEIASQYEGQIKVVKINTDENPNVASQYGIRSIPTLMIFKDGQKVDMVVGAVPKTTLANTLEKYL
>NC_019751.1|WP_015200756.1|6338280_6339396_+|Gfo/Idh/MocA-family-oxidoreductase
MTNQGVIGIAIIGTGFGQKVHIPGFQAHHRTKVVAVYHRDINKAKQIATANQIPHSCDNLDDILNLPEVQAVSISTPPFLHYEIAKQVLAAGKHLLLEKPVTLNVKEAKELYQLAQQKGVIATVDFEFRYVPGWQLFSQLLSQEYVGKKRLIKIDWLGASRADATRPWNWYSQQSQGGGVLGSLGSHAFDYINWLFGAVNKLSAHFTTAIPQRPDPQTGELKVVDSDDTCMLMLELADGTPCQVSISAVVHAPRPHSLEVYGDAGTLILESENQKDYIHGFRVKGSKIGQPVAEIEIPQHLLFPKNYSDGRISAFLRVVDQWIQGIDQGEAVIPSLKEGVYSQLLMDLATESHHNFRWVDVPNLEDFILIP
>NC_019751.1|WP_015200769.1|6353716_6354934_+|FtsX-like-permease-family-protein
MNIIESMTMAGKTLLSNRLRSALTMLGIVIGNASVIAMIGVGEAGQKYVAKQLESLGPNVLFVLPGNQETQQISFEVPKNLVLADADAIASQVPTIAGVAPELNRRQRVAFKNRNSDENIIGTTPSFLIVRDFDTAKGRFFSDVDMKRSNQVVVLGSKFATKFFGTNNPIGQQIRIKDSRFEVIGVLREKGSSFGADYDKVLVIPITTSANRLIGRNSPYGLGVDYIVASARDAKSVDGAVFQITNLLRLRHKINGEDDFSIQTQKDALKTVGQITSALTIMLAAIAAISLFVGGIGIMNIMLVSVTERTHEIGLRKAIGATQQDILLQFTIEAVIVSAAGGLIGAIVGVSGVLLVAALTPLEAAISPIAIASAVGISGAIGLFFGVVPARRAAKLDPIVALRSA
>NC_019751.1|WP_015200770.1|6354998_6355814_+|ABC-transporter-ATP-binding-protein
MNQEQAINLNSSATVFNSATKEDVEASQVLNPSHLKPIIRLENIFKIYGIGETEVRALNDVNLIIEEGEYCAIMGPSGSGKSTAMNIIGCLDQPTSGHYYLDSLDVAQMEDKQLAHIRNKKLGFVFQQFHLLQQLTALENVMLPMVYASIPNNERKERATEALIKVGLEKRMHNKPSQLSGGQQQRVAIARSIVNRPVVLLADEPTGALDSRTTQEVLDIFTELNSSGITVVMVTHEPEVARQTRRIVWFRDGEVIHSNLTPADLNQVAMS
>NC_019751.1|WP_015200771.1|6355915_6356455_+|SH3-domain-containing-protein
MSLRTKATAGLLALGTLMTGILPAIARPATVTTTSNLRTDASLRAPVEQILPPSSNIEVLNIRVGNDGNYWYYVQPKVKGILSGWIRSDLVSFNPSNKRYATLAGSRGSKINVRAAATLNSKAIHYGLVGDLVTVEDSYKAPGQFRWYRVRFPSNASGWVRGDLLSIWQQGCIITCPEH
>NC_019751.1|WP_015200772.1|6356563_6358093_-|protein-kinase
MNLCINNKCHKPQNSDNNTFCSNCGSELLIAGKYRVLNQISQDGYSRTYEAQEIADSQSKPHKILQVFSITDSGEIELLQKIVTALQIIDHPGITQITTDSYFTYLPRNSTSPLHCLIIDKISGITLDEYMYKQDYHPVDEYLVLKWLKESVNILQLLHQQSILHLRINPQNILLKDDGNLALVDIIAVNRTKSSDGIAYSPYIPPEQFNNSPIPQSDLFALGMTFAYLLTGKEATKDPDAYQSDETKLKWQSFVPNMNKVSQLPILLDSMMAHAPIQRPQNCQVVLDSLDSFAKSQISSPHAETIISQPPKSQNSKLVKLLFLINWILATITGVTLGGVIGLIAGWCVSFLLGAAIRNVSTGIILGGVVFGLTTGLVTGIMQSWVFWQCGYKIKYWILLTTLGFAIEGALGIAIGNYNYGEKIMIVPGIVVGISQFLLLKNHINYSFLWIFINILGGGLAILVHWQMRDILIGKYQFFSYILGLMAFGLVTGISFIKLQIDKPLLEVS
>NC_019751.1|WP_015200773.1|6358230_6359058_+|deoxyribodipyrimidine-photo-lyase
MANDMKRDFANREELISYLREQFPQAAERDDHISEIVGGRKAAEKTLQKVDPSKYGKTRNFFSGAVTRLSPYLRYGIFSLREVRDFSLAKVNNRDDVTKLINEFGWRDYWQRLYFKLGDRIWENQEDFKTGYSIGEYVAELPEDIKEGTTGMVCMDSFSGDLRTTGYLHNHARMWMAAYIVHWRRIRWQTGAKWFLEHLLDGDPASNNMSWQWVASTFSHKPYFFNRENLEKYTEGIYCQVCPLRGKCVLEGSYEEIQAKLFPKGEFSKSGGKSR
>NC_019751.1|WP_015200774.1|6359206_6361645_-|penicillin-binding-protein-1A
MIKFTSWFKDKSTKLTDAKTSAETPEGEASPDELEDEKPPQGKAKQLLNRVGKVPSAILSKLPGSPKPLYRRYWFWAGAILTGGFVGVTSTISSIDKTLPSSSQLNSVAREQTLTIKAADGTILQQSGPATREQLSVDEIPEKLKQAFIASEDRRFLKHDGVDGQGIVRAVVNNLRSQNLVEGGSTITQQLARILFLKQEKTLLRKVREVRLAQKMERELSKDKILERYLNLVYLGSGAYGVADAAETYFSKPAKELTLAQMATIAGLAPAPSVYAPDRNPEAAKQRRNLVLQRMLEDGVITPEQKQEAISEPLTVTASQPKRMQVVAPYFTSFIQKELPNYVSQEVIEAGGLTVETTINPAWQELAENAVAKTLRNQGRWENFKQAALVAVDPRSGEIKVMVGGKDFGKNQFNRATQAKRQPGSTFKGFVYATAIATGMSPYQEFLDSPLIVDGYEPKNFDEGYRGSMDLRTAITKSINIVAVRILLKVGFDPIIQLAKKMGIKSELKPTYSLALGSSEVNLLEITSAYGSFATQGIHNEVHGITRVVNRQGEEVWKANFTPERALDEDSAKIMTWMLRNVVQNGTGSPAQLSDRAVAGKTGTTDEARDLWFIGYIPQLVTGVWLGNDNNNPTYGSSASAAYTWNQFMAKAVKGMPVEKFPERPKLEGRKASIKAEPVRGRRVVNRAIPDRDNKDNGNGEETPRRRRNRQETSSDSNTEQRSSRRRRRNSEETQETPRRRSRRSRSEESNSNSSSSESRSRRRVDSNSSSESRSRRSSGSSTNNGSGKSNSSGSSQSSGSSWRERLRPDAQ
>NC_019751.1|WP_015200775.1|6361975_6362473_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MDKEINKSAIALGSNLGNSLEILESAIASLVEIPGIRLNRKSSWYRTKAIGPPQPDYINGCVILEVEMTPELLLATLLKIETDFGRVRQERWGARTLDLDILLYADRIIDLPTLQIPHPRMCDRAFVLVPLNEIAPDWIVPVSGFAIKDVIKAVDCSDVSLLMGN
>NC_019751.1|WP_041739983.1|6362560_6363112_+|NUDIX-hydrolase
MPLGRELPQLLKQRLFYKGRKFDFEVNRLRLPNRVEGDWECIRHPGGALVIPVTNEGKLVLVRQYRFAVGGRVLEFPAGTIEPMEEPLETVKREIQEETGFSANKWQKLGEFILAPGYSDEIIYAFLAQDLTKLEMPPQQDDDEDIEVLCWTPQELEKAILEGQPVDAKSISSFFLARPFLGL
>NC_019751.1|WP_015200777.1|6363262_6367126_-|hypothetical-protein
MSSDFEQQRKISVLLPAIHPELLTGLDKLLSLGLISDSQVRKICEGSLTCKLPIQEEVESDPFGELTIPFFSAEVPEVEEIPPVSKKVPVVAGMLQSLVAELSVRWLLFLGMFLVVVSSGVLAATQWERFPVAGQYGILFGYTLSFWGISFWTVKQQNLELTTQALLTVTLLLVPVNFWAMDGFRLWQNPLNWVVIAFAAVILTGVTILISGSLVFAANSEKKNLRLANILGLSFLHWGWSLGSFPLISIYVAMVGTSFLSVSQSVLGSRRQNPRLGINLPISIIIYALVLLLSRGIFVVGVDVSKLGLAIGICGWLIAWLAMKQEKLTEEGVNSDFSPPWELIGGFLLLLGWLVTITTQPAQALAVSGLGLWFGLRRLQLYSLVIDYLGIFVVGLQANWLIWRLVPLPIQGQILQFLNQVTYSQNQNWVFLSLGLFPFLLVMVLLGETLHHQGESKLAKFSEKTNLGFGILLATISIVNPATRSLNLFLSCFTLATVYKGRNFQVSQSFIFFLHTTAVITLLSFINWVFPTLQVEYWGIILLTLMVGEWLYSVGEGFWRQSAWYIGFGLATISFYLLWGYQTQGASLAPSNISSYISTYPIQDNWNLAWLVTPITLTVIASRGEANKRRLNYVSSFISLGVLQFLTFPLDKVRLIGLGTAAALMLVNTNYVDELEFAVITVGFILTFIAACCWEFLNLSISAWHVIGAMMVLGLWLTRQFLVSRESDREENSIYIEALNKWAVALCIGELFLLTIHSVLVYQGIAKAETLYLLAIVITLAAIVFRTWKYPTNRGFYAIGLSLELLVAEALAFSGRSGVKIAIANIILAIATQVVGEFWLRKHRLQRLPKSFHVLPLIYGIFSVILRLDIFTNYTGVLSLGVALIMITVGRRGRELKPILFLGIVGISVSAYETLIYHMLQSSGGAYGDGLIAMSALGAFIMYAYRLLSPWLTSYLRLSTAEVEIIAHCHWILSSFLLVSGIFAPIGINRFVGLGTGLFLARYAIFQARHSEKNIADETWVYLGLMEAGVVSYLLKDIAIGRIFTQQLLPWNAAIACIGAFILYILPWQRFGWSKTPWRNAAYVIPLLILYTTWLEVNSITLILVAGFYLFIAKANQQIRFTYISIALINWALWNSFRDFNLTDGLWYITTVSLSILYIAQIDPSLQQPQMKENRHLLRILGTSLICGYALILHQDSAWIPGIFSLIGIFAGLALRVRAFLYIGTVTFLGTSIYQLIIFSLRYPFLKWVVGLLLGIALISIAANFETRKEQLNSIFRSSNSGIQEWE
>NC_019751.1|WP_015200778.1|6367277_6367865_+|Uma2-family-endonuclease
MISQTLEQPIPLPEQRFLLPGYYSWSEFETIDAVVGDCRSLRITYLDGCIELMTVGEKHEMLKKVLAILLETYLFATGINFTPIGSGTRRSKEKDVSFEPDESYYIGEKKEHPDLAIEVNITSGSIDKLQKYQRLQITEVWFWEDCTLALYRLRDEGYVKVDSSELLPDLNISLLIDCILKPSVIEARQEFLKGI

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_019751_1	1.1|316595|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	316595-316630	36	NC_019751.1	193339-193374	0	1.0
NC_019751_2	2.1|324354|39|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324354-324392	39	NC_019751.1	6107853-6107891	0	1.0
NC_019751_2	2.2|324428|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324428-324462	35	NC_019751.1	4731866-4731900	0	1.0
NC_019751_7	7.12|2022697|32|NC_019751|CRISPRCasFinder,CRT	2022697-2022728	32	NC_019751.1	6375759-6375790	2	0.938
NC_019751_12	12.2|2712653|28|NC_019751|PILER-CR	2712653-2712680	28	NC_019751.1	2470424-2470451	1	0.964

1. spacer 1.1|316595|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to position: 193339-193374, mismatch: 0, identity: 1.0

gaaactgcttctgctgattgagttaaaaaggatttt	CRISPR spacer
gaaactgcttctgctgattgagttaaaaaggatttt	Protospacer
************************************

2. spacer 2.1|324354|39|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to position: 6107853-6107891, mismatch: 0, identity: 1.0

taggaagttttcgcttgggtattgcttaatttagcagag	CRISPR spacer
taggaagttttcgcttgggtattgcttaatttagcagag	Protospacer
***************************************

3. spacer 2.2|324428|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to position: 4731866-4731900, mismatch: 0, identity: 1.0

tatttaaggctatatcgcttctaaattgagagaca	CRISPR spacer
tatttaaggctatatcgcttctaaattgagagaca	Protospacer
***********************************

4. spacer 7.12|2022697|32|NC_019751|CRISPRCasFinder,CRT matches to position: 6375759-6375790, mismatch: 2, identity: 0.938

ccagcacgagtgcgatcgccgattgcgatcgc	CRISPR spacer
ccaggacgaatgcgatcgccgattgcgatcgc	Protospacer
**** ****.**********************

5. spacer 12.2|2712653|28|NC_019751|PILER-CR matches to position: 2470424-2470451, mismatch: 1, identity: 0.964

acgactttcgtcgcgcaagcttcgcatc	CRISPR spacer
acgacttgcgtcgcgcaagcttcgcatc	Protospacer
******* ********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_019751_12	12.2|2712653|28|NC_019751|PILER-CR	2712653-2712680	28	AP018277	Calothrix sp. NIES-4101 plasmid plasmid4 DNA, complete genome	69511-69538	3	0.893
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP025013	Rhizobium leguminosarum strain Norway plasmid pRLN1, complete sequence	336395-336430	4	0.889
NC_019751_12	12.2|2712653|28|NC_019751|PILER-CR	2712653-2712680	28	NC_019728	Calothrix sp. PCC 6303 plasmid pCAL6303.02, complete sequence	48794-48821	4	0.857
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP025013	Rhizobium leguminosarum strain Norway plasmid pRLN1, complete sequence	336401-336436	6	0.833
NC_019751_13	13.1|2924973|33|NC_019751|CRISPRCasFinder	2924973-2925005	33	NZ_CP014853	Bacillus thuringiensis strain HD12 plasmid pHD120345, complete sequence	104222-104254	6	0.818
NC_019751_1	1.9|317168|38|NC_019751|PILER-CR,CRISPRCasFinder,CRT	317168-317205	38	MN694186	Marine virus AFVG_250M615, complete genome	50697-50734	7	0.816
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NC_008269	Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence	509802-509837	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	MH509446	Gordonia phage DelRio, complete genome	6233-6268	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	MN539018	Salmonella sp. strain OYZ4 plasmid pOYZ4, complete sequence	121304-121339	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP044306	Escherichia coli strain C27A plasmid pC27A-CTX-M-55, complete sequence	130749-130784	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP027411	Salmonella enterica strain FDAARGOS_319 plasmid unnamed, complete sequence	73177-73212	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP028537	Enterobacter hormaechei strain SCEH020042 plasmid pQnrB4_020042, complete sequence	45648-45683	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_AP023191	Escherichia coli strain TUM18530 plasmid pMTY18530-1_lncHI2, complete sequence	47039-47074	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	MN539017	Salmonella sp. strain PJM1 plasmid pPJM1, complete sequence	71641-71676	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	MT077888	Escherichia coli plasmid p65, complete sequence	47133-47168	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NC_009838	Escherichia coli APEC O1 plasmid pAPEC-O1-R, complete sequence	46537-46572	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP039170	Salmonella enterica subsp. enterica serovar Goldcoast strain Sal-5364 plasmid pSal-5364, complete sequence	69624-69659	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	CP048299	Salmonella enterica subsp. enterica serovar Schwarzengrund strain WAPHL_SAL-A00527 plasmid pN1566-2, complete sequence	195981-196016	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	CP048303	Salmonella enterica subsp. enterica serovar Schwarzengrund strain WAPHL-SAL-A00375 plasmid p28945-2, complete sequence	41269-41304	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP037959	Salmonella enterica subsp. enterica serovar Goldcoast strain R18.0877 plasmid pR18.0877_278k, complete sequence	45080-45115	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP039861	Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:- strain PNCS014880 plasmid p16-6773.1, complete sequence	239714-239749	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP048776	Salmonella enterica subsp. enterica serovar Agona strain SG17-135 plasmid pSG17-135-HI2, complete sequence	45080-45115	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NC_019114	Salmonella enterica subsp. enterica serovar Heidelberg plasmid pSH111_227, complete sequence	43330-43365	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_AP023198	Escherichia coli strain TUM18780 plasmid pMTY18780-1_lncHI2, complete sequence	47039-47074	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP043223	Salmonella enterica subsp. enterica serovar Bredeney strain SA20114778WT plasmid pET1.1-IncH, complete sequence	5930-5965	7	0.806
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP043223	Salmonella enterica subsp. enterica serovar Bredeney strain SA20114778WT plasmid pET1.1-IncH, complete sequence	240151-240186	7	0.806
NC_019751_12	12.2|2712653|28|NC_019751|PILER-CR	2712653-2712680	28	NZ_CP030828	Neorhizobium sp. NCHU2750 plasmid pNCHU2750a, complete sequence	631683-631710	7	0.75
NC_019751_1	1.11|317313|37|NC_019751|PILER-CR,CRISPRCasFinder,CRT	317313-317349	37	NZ_CP044488	Acinetobacter schindleri strain HZE30-1 plasmid pHZE30-1-5, complete sequence	1616-1652	8	0.784
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP035001	Rhizobium acidisoli strain FH23 plasmid pRapFH23c, complete sequence	325884-325919	8	0.778
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	MH509446	Gordonia phage DelRio, complete genome	6227-6262	8	0.778
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	MT758688	Mycobacterium phage CELFI, complete genome	74676-74711	8	0.778
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NZ_CP029452	Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence	619935-619970	8	0.778
NC_019751_2	2.10|325005|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT	325005-325039	35	NZ_LR214986	Mycoplasma cynos strain NCTC10142 plasmid 13	170929-170963	8	0.771
NC_019751_7	7.10|2022554|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT	2022554-2022587	34	CP011076	Brevibacillus laterosporus strain B9 plasmid unnamed2, complete sequence	1012108-1012141	8	0.765
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NC_008269	Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence	509808-509843	9	0.75
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NC_019201	Streptomyces sp. x4(2010) plasmid pTSC1, complete sequence	240-275	9	0.75
NC_019751_2	2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	324719-324754	36	NC_008269	Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence	509814-509849	10	0.722
NC_019751_9	9.11|2038850|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT	2038850-2038885	36	MN013189	Microcystis phage Mic1, complete genome	65035-65070	10	0.722
NC_019751_2	2.12|325146|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT	325146-325180	35	MN693352	Marine virus AFVG_25M558, complete genome	46200-46234	11	0.686
NC_019751_7	7.12|2022697|32|NC_019751|CRISPRCasFinder,CRT	2022697-2022728	32	NZ_CP007257	Rhodococcus erythropolis R138 plasmid pLRE138, complete sequence	69014-69045	11	0.656

1. spacer 12.2|2712653|28|NC_019751|PILER-CR matches to AP018277 (Calothrix sp. NIES-4101 plasmid plasmid4 DNA, complete genome) position: , mismatch: 3, identity: 0.893

acgactttcgtcgcgcaagcttcgcatc	CRISPR spacer
acgactttcgtcgcgcaagcttcgcggt	Protospacer
*************************. .

2. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP025013 (Rhizobium leguminosarum strain Norway plasmid pRLN1, complete sequence) position: , mismatch: 4, identity: 0.889

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
tgtctcggtctcggtctcggtctcggtctcggtctc	Protospacer
 **.* .*****************************

3. spacer 12.2|2712653|28|NC_019751|PILER-CR matches to NC_019728 (Calothrix sp. PCC 6303 plasmid pCAL6303.02, complete sequence) position: , mismatch: 4, identity: 0.857

acgactttcgtcgcgcaagcttcgcatc	CRISPR spacer
acgactgtcgtcgcgcaagcttcgcggt	Protospacer
****** ******************. .

4. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP025013 (Rhizobium leguminosarum strain Norway plasmid pRLN1, complete sequence) position: , mismatch: 6, identity: 0.833

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
gggcactgtctcggtctcggtctcggtctcggtctc	Protospacer
.* .   *****************************

5. spacer 13.1|2924973|33|NC_019751|CRISPRCasFinder matches to NZ_CP014853 (Bacillus thuringiensis strain HD12 plasmid pHD120345, complete sequence) position: , mismatch: 6, identity: 0.818

-agattttaagataaacagtatattctctctcta	CRISPR spacer
cacataat-agagaaacagtatattctctttcta	Protospacer
 * **  * *** ****************.****

6. spacer 1.9|317168|38|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to MN694186 (Marine virus AFVG_250M615, complete genome) position: , mismatch: 7, identity: 0.816

agtagcacaatcccattcagtaattgca-catacttttc	CRISPR spacer
actagcacaatcccattccgtaattccaccatattgct-	Protospacer
* **************** ****** ** ****.* .* 

7. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NC_008269 (Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcg---gtctcggtctc	CRISPR spacer
ggtctgggtctcggtctcggtctcggttgtctgggt---	Protospacer
.**.**.******************   **** ***   

8. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to MH509446 (Gordonia phage DelRio, complete genome) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
cgactccgtctcggtttcggtctcggtcgcggtctc	Protospacer
 * .*  ********.************ *******

9. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to MN539018 (Salmonella sp. strain OYZ4 plasmid pOYZ4, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

10. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP044306 (Escherichia coli strain C27A plasmid pC27A-CTX-M-55, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

11. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP027411 (Salmonella enterica strain FDAARGOS_319 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

12. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP028537 (Enterobacter hormaechei strain SCEH020042 plasmid pQnrB4_020042, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

13. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP023191 (Escherichia coli strain TUM18530 plasmid pMTY18530-1_lncHI2, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

14. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to MN539017 (Salmonella sp. strain PJM1 plasmid pPJM1, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

15. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to MT077888 (Escherichia coli plasmid p65, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

16. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NC_009838 (Escherichia coli APEC O1 plasmid pAPEC-O1-R, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

17. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039170 (Salmonella enterica subsp. enterica serovar Goldcoast strain Sal-5364 plasmid pSal-5364, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

18. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to CP048299 (Salmonella enterica subsp. enterica serovar Schwarzengrund strain WAPHL_SAL-A00527 plasmid pN1566-2, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

19. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to CP048303 (Salmonella enterica subsp. enterica serovar Schwarzengrund strain WAPHL-SAL-A00375 plasmid p28945-2, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

20. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP037959 (Salmonella enterica subsp. enterica serovar Goldcoast strain R18.0877 plasmid pR18.0877_278k, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

21. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039861 (Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:- strain PNCS014880 plasmid p16-6773.1, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

22. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP048776 (Salmonella enterica subsp. enterica serovar Agona strain SG17-135 plasmid pSG17-135-HI2, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

23. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NC_019114 (Salmonella enterica subsp. enterica serovar Heidelberg plasmid pSH111_227, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

24. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP023198 (Escherichia coli strain TUM18780 plasmid pMTY18780-1_lncHI2, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

25. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP043223 (Salmonella enterica subsp. enterica serovar Bredeney strain SA20114778WT plasmid pET1.1-IncH, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

26. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP043223 (Salmonella enterica subsp. enterica serovar Bredeney strain SA20114778WT plasmid pET1.1-IncH, complete sequence) position: , mismatch: 7, identity: 0.806

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
atcttctgattcggtatcggtctcggtctcggtctc	Protospacer
* .**  * .***** ********************

27. spacer 12.2|2712653|28|NC_019751|PILER-CR matches to NZ_CP030828 (Neorhizobium sp. NCHU2750 plasmid pNCHU2750a, complete sequence) position: , mismatch: 7, identity: 0.75

acgactttcgtcgcgcaagcttcgcatc	CRISPR spacer
tgaacttgcgtcgcgcaagcttcgatta	Protospacer
  .**** ****************  * 

28. spacer 1.11|317313|37|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP044488 (Acinetobacter schindleri strain HZE30-1 plasmid pHZE30-1-5, complete sequence) position: , mismatch: 8, identity: 0.784

acatttaacaaattattttgtcaaatctgaa---aaatca	CRISPR spacer
agctttaacaaattattttgttaaagctgtactcaaa---	Protospacer
*  ******************.*** *** *   ***   

29. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035001 (Rhizobium acidisoli strain FH23 plasmid pRapFH23c, complete sequence) position: , mismatch: 8, identity: 0.778

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
ctcttccatcgcggtctcggtctcggtctcggtctt	Protospacer
  .**  .** ************************.

30. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to MH509446 (Gordonia phage DelRio, complete genome) position: , mismatch: 8, identity: 0.778

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
cgtctcggtttcggtctcggtcgcggtctcggtgcc	Protospacer
 **.* .**.************ ********** .*

31. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to MT758688 (Mycobacterium phage CELFI, complete genome) position: , mismatch: 8, identity: 0.778

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
ggtacccgtctcggtcccggtcccggtctcggtccc	Protospacer
.** .  *********.*****.***********.*

32. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029452 (Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence) position: , mismatch: 8, identity: 0.778

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
ggtaccggcctcggtctcggcctcggcctcggtctc	Protospacer
.** . .*.***********.*****.*********

33. spacer 2.10|325005|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR214986 (Mycoplasma cynos strain NCTC10142 plasmid 13) position: , mismatch: 8, identity: 0.771

gaatgaaaagatttttacatcttttgctgataaaa	CRISPR spacer
agatgaaaagaattttaaatcttttgcataaaaca	Protospacer
..********* ***** *********  * ** *

34. spacer 7.10|2022554|34|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to CP011076 (Brevibacillus laterosporus strain B9 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

ttgataatagtattctgaatactctg-gtgtaatt	CRISPR spacer
ctgataatagtattcggaatattctgcttgttgc-	Protospacer
.************** *****.****  *** .. 

35. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NC_008269 (Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence) position: , mismatch: 9, identity: 0.75

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
caactgggtctgggtctcggtctcggtctcggttgt	Protospacer
 . .**.**** *********************. .

36. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NC_019201 (Streptomyces sp. x4(2010) plasmid pTSC1, complete sequence) position: , mismatch: 9, identity: 0.75

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
tccctggtgctcggtctcagtctcggtctcagtctc	Protospacer
  ..**.  *********.***********.*****

37. spacer 2.6|324719|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to NC_008269 (Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence) position: , mismatch: 10, identity: 0.722

agtttgagtctcggtctcggtctcggtctcggtctc	CRISPR spacer
gaacggcaactgggtctgggtctcggtctcggtctc	Protospacer
.. . * . ** ***** ******************

38. spacer 9.11|2038850|36|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to MN013189 (Microcystis phage Mic1, complete genome) position: , mismatch: 10, identity: 0.722

----caagctttgtacaacttcaagaaaaatcaaatagtt	CRISPR spacer
gtgctagg----gtacaaattcaagaaaaatcaaagagcc	Protospacer
    .*.*    ****** **************** **..

39. spacer 2.12|325146|35|NC_019751|PILER-CR,CRISPRCasFinder,CRT matches to MN693352 (Marine virus AFVG_25M558, complete genome) position: , mismatch: 11, identity: 0.686

ctttgatgtaagaaaactcatcactagcaaaaaaa	CRISPR spacer
agaaagaataagaaaactctttactagcaaaaaga	Protospacer
    .. .*********** *.***********.*

40. spacer 7.12|2022697|32|NC_019751|CRISPRCasFinder,CRT matches to NZ_CP007257 (Rhodococcus erythropolis R138 plasmid pLRE138, complete sequence) position: , mismatch: 11, identity: 0.656

ccagcacgagtgcgatcgccgattgcgatcgc	CRISPR spacer
gggaaacgagcgcaatcgccgattgcgaagat	Protospacer
  .. *****.**.**************  ..

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	249445 : 282790	28	uncultured_Caudovirales_phage(20.0%)	transposase,integrase,protease	attL 248527:248543|attR 296427:296443
DBSCAN-SWA_2	291354 : 360224	50	Lysinibacillus_phage(20.0%)	transposase,tRNA,protease	NA
DBSCAN-SWA_3	2803324 : 2918529	96	Liberibacter_phage(16.67%)	transposase,tail,protease,plate	NA
DBSCAN-SWA_4	3927849 : 3988730	44	Bacillus_virus(16.67%)	transposase,holin,tRNA,protease,bacteriocin	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_019751|249445:282790|DBSCAN-SWA
TCTACATATTGCTAATCCTTTCGATAATCTTCTCACACACAATATTGAGTGCTTGCTCCACCTTTGAAGTTAAATCCCAACCAAAGTCAATGTTTCCTGCTTCTATTAGGTATACCGTCACGTCTAAGGGGAACTCATGGGGAAAGATTTTCCTCCCCGATGCGATCGCATGATGCCACCGGAAGTCATGTAAACTATAACCAGGCTCCGGTAACTCTACAAGTTCATCACCAGGAACCTCAAATACTGCACCAGGTTCAGAATCACTACAACTAGCATCAATGATAATTAGCTCTGTACAACCCCGTGCCTGAAACATCACCTCCATTCCTCCAGTTCCGCAATCATAAACCCGTATATCTGGATGAGGATGTTGAATTAGGTATCTTTGCAGACGTTGCGCTACCAAAACACCAACTCCATCATCACTACGATTTAAATTTCCACAACCAATAATAGCTAGCATTGATTTAAAGATTAATTAAGAACTTAATACCAATTCAAAAAAAGTGCTGCATATAGTAGTTAAAACGATTGTTCGCTTCATTGCTACAGCGGAATTAAGTGCAAAACGAGTTAATTTGGAAAAAAAATTATTTCCATGTTAGTTTTGTTTCTTTTTGGGGAAGTATAACTGAAGTTTGTTGTATAAACAGCAACTAAACAATGTGAGTTTTATTCCCTAAGGAAAGTGTAAATCATGGCTAAAAGAAGTTTTCCTAATTCTCGTCGTAATACCCAAGTTACTTTAGAACCAGAAGTGGCAATTGCTGTTGTCGGCATTTTCTCCTCCCTTGCTGATGGTGACGAATTAGGACATGAAGAAGACTATGCTCTTGGTGAAATGTTATGTAGTGTTTCCGGATTTGAAGACTATTCCGAAGAAGACTATGTGAACTTGTATAATCGTGCGATCGCAGTCATTAACGAAGAAGGAGCAGAGGAAGCATTTACACAAGCGATCGGTAGTTTACCAAACAAAAATTATCGAGAAGCTGCATACGTTACAGCTGTCACAGTCGTATCTATTGATGGTGAATTTCCTGAAGAAGAAGAGGATTTTCTCGCAGGACTTCAAGAAGCTTTGAAAATATCAGATACCAGAGCAGAAGAAATAATCGATGAAATTTTCTGCGAAGACGAAGAGGAAGAAGAAGAGTAATTTTAAATTCCTTTATCACAATTTAGGGATTGTATCTCACCAAAAAAAATCCCATTTTACCCCCTGAGATCACTCAGGGGTTTGTACATTTCTTAGTCTAGACAGAACTTCCGCAAGACACTAAATCTAGGAGATGAGACGTAACTACACCATTCATCCAAATATCAGAATTCTGAATTTGTAACTTCACAATTCCACCATTAGGAACCTTAAATATATCTAGAAAAATCTTAATTTTCTGCATACTTTCAGGACTAATTTCTCGTGAATTAGTTAGCAACAACCAAATAAATACTCTCATAAATATTTCGTGGGTAAAAATTGCAGTAAATTTATTTTCTAGCTGAGAAATTTGCCTTTGCAAACCAAAGCAACGCTCGATCATTTTTGCAAAAGACTCTGCACCCTCTCCATCAGAATAAAACGGATCACAACGTTGCCAATATTCTTCAGCCATTGGAACACGTTGACTTAAAGTTGTATTTTTACGTCGCATAGTTGCTAAATAACTAAATTCCTGCACTTCCCACTCGCTTTGAGGAATTCTTGGAAAACGCTCGATAGTCGGTTCCGCTGTTTGTTTAGTTCTTAAATAAGGAGAAGTAACAATTAGCGAAGGTTGTTCACTGAAAAATAAAGCTACTTTTTTTGCTTGTTGCTGTCCTTTTTGCGTCAATTTAATATTTTCTACTTCCGCAGTCACCAAACCTGCGTTTGCTTCACTCTCACCATGCCGAATTAACCAAACTATAGCCATAATCTTTTATCGGTTATGCACTCACTCCCAGGAATGTTATCATATCGCCTTCTATTAGGTATGATGCTCAGGTAGTGTATTTACTGAAAATACAATTAAAATTTGTATCAAAATTTCACGGACTACAAAATTCCCAACTGATTTTGTCAATCGGGAATCTAACTATTCTCTAAGATGAAATTAAAATATTCTATATAGCTGTAATTGATGCAAAAATTTACAAAACTACATTATATTTTGCCGCAATTTGATTTAACTTATCGAACTGTTGTTGAGATGCTTGAGCTAGCTTTTCATCAGTAGATAAAGTGCTTTTCTTCCCTTTAGGAAGTAGATATTTCACATAAAGAGAAATAAAATCTACTACAATTGGTAAACCCTTAAGATCATGGTTGTCAGCTTCTTTACCAGCGGCGAATGCTGCCATTCCACCTTCAATTGTATTTCTAGTCGCATTCATGAATTGATCCACTAGTTGTTCAACATAATGTCCACCAGTGAATTTTTTTAACTTGATGCTATCTGGAGTAAATTCGTATCCACCTTCCTTCGCTTGATCCAACATGCACCATTCTGCAAGTTCCTTGAGTGCATCTTCTGGAAGTTTCGCGAGGTGAGGATGTAAATCTAATTCTGACATAATTGCTCCTTAGAAAGTAATAAGATAATAAATCAGGAAAAGTTTGTTAGTTATGGCTAAAGTTAAGGTAATAAGGGTACATCACAGTTTTTGTTTCGCAAATAAAAAATATTTTTTTTATTCAATATTCAAAAAGTGGATGTTCCTAGTACAGTTCGGCGTAAATAAGCCAACCATTACAAACAGACCAAAAGCTTGTTTTATTGGCTTTATTCCTTCTGCCTTCTGCCTCCTGCCTTCACGTACTAGGTAATAACTGAGGTGCTAATTACTGTTGCCATTTCCAGTTACAAGAATTTCATTTTCTGTATTTTTTGTGAATGTGTACAGTTCATTCAATTTATCTAGAGGAGTAATCACCATGCCAATTTTCGGAACATTTCTCAGATCTAAAAGCAAGAAAAATTTACCTTTATTATAATATTTTGATGTTACTTCTGACAACAGTAATTTGATGTAGCAATCTTCAGCTTCTGTAACCTCATGATAATAGGAAATGTGAGCTTTTGTATCAAAATATAACTCCGCAGAATAGATAGATTTACGAATTTTAACCGTGATATTTATGGGAAAAGAGTCGTTGGGAATAATAGTCATCAACAAAAAGTCCTCTAATTTAATTTTAATTTGTAGAGATAATGTTATTATTTTTCAATAGAATCAATACTATTTTTCGCGGATGTAGAGATTAATAAAGAAAGATTAACGCTAATTAGAAAAGGATTTCGTACATTAGGCTACCATCGTCAATGGGAATTGAATCAAACTCAAGTAAGGTGGATAAAGCAAAACCCGGGTCTCTCACAAGTGAGAAATCCGGGAGTAGGGAATAGCATAAATCTTAAAAGTTTTCCGTTTGTTCTGGTATGCCTTAGTTCACGATGCTTAACCAGAATCAAATAGCTAGGAATATGAAAGATCGAATCCTATTTACCAAAAGCGTCTTTAATATTATCTACAGTGCGTTCAACAGCATTCTTTGTATCATCTACTGCTTTTTTGGTTTTAGCTGCATCTTCATCGGCTCTACGTTGAATTGTAGCTGTATCTTTAAGAGCTTTGCGCTGGACAAAACTGCCATTGCCGTCTGTTGATTCTGCTACTTTGCTTGCATTTCGTTTTGCAGTATTTTTAACTTTATCTGCTGCATCATCAATAAAGTTCTTAGTTTGTCCAGCATCTTCGTTGGCTTTACCTTTAACTGTAGAATCTGCGTTAGCTATGAAATTTACGCTAGGTGCAGCTATTGCTGTAGTATTTGATAATAGTGAAGAATGCCAAGTGAAAGCTATAGCCGAAAGGCAAAGCACTGTTATAGCAAGGAAGTTTCCTACAGTTGAAAGTCTTTTGCTGAAATGAGTTAGTTGCATAGGATACAGTTTTTATTTTCTTTACACGTATCCTATTTTTACTTCATTTGACTCTCGGCTCAAATCCTTCTGTAGCTAGACATGGTTTTTATCAAAAGATAGAATCTACAGGATAGACTTGTCGTAGCATTAGGCAGGGTTAGCTTGCATTCTTCTCTCAAGCAAAAGCCTAATTGCAGGTTTTTCTAAGATACCTACCAAAACACCATTCTCACGAATCACAGTTAATGCGGAGAGTTTTTGTTGCTCAATTAGCTGCACCACTTCTAACAATGGTTTGTCAGCTTGGACTGTGGTGGATTCGGCAATTGGTTGCATGACATCTTTGATTTGAGTTTCTGTCCACAATTGCGTCGGGATGGAACGCATATTATCAAAAGATATTGCTCCTACCAATTGTCCATCATTGTTGGTGACTAAAAAACGTTGCCAGTTTTGTCCACTGATAATTTGCTCGTCTGCAAACTCTCTCAGAGTCAGATCAGCAGAAACAATTGGACTATCATTACTCACAGCGTCACTAGCGGTTAAACCTGTGAGTTGTTCTTGTACTCTGGCAACTTGGGCTGCATTACCGGCATTTTGTAATAAGAAGAAGCCAATCAACAAGTTCCAGAAGTTACCAAAGCTGCCAACCAAAAATAGCGGGATTAAGCCAGATGCGATCGCTATCCAACCAAAAGCTTGTCCAACTCGACTGGCAAATACTACTCCTTTGTTGGGATTACCTGTAATTTTCCAGACAATTGCTTTCAGTATATTTCCACCATCCAAGGGTAAGCCAGGTATTAAATTAAATGCAAACAGCGACAGATTAACAGAAGCAAGTACCCCTAAAATTCCTGCCAAGGCTCCAGATACACCAGTACCAAAGCCAATCCCTGCAAAGATACCGAATAGAAATAGACTAACCAAAGGACCTGCGATCGCTACCCAAAAGGCTTCGGCGGGAGTCTTTGATTCTCTTTCTAAGCTTGCCAAACCCCCAAATATAAACAGTGTGATGGATTTAACATCAATTCCCTGACGAATAGCCACAAAGCTATGCCCCAGTTCATGGGCAACAACGGAAGCAAATAGCATCAACGCCGTCATCAAACCCAGTAGTAAAGCGAATCCATTCCCTAAATCAGGAAATGCTGCTGATAAACCACTTCCATAAGTCCATGTCACCAAACCCAGCACTAAAAACCAGGATGGATGGATATAGAACGGAATCCCGAAGAGATTGCCAACACGAATTGTGTTATTCATGGCGTTTACCTTATATTTCTAAATTGAGAGGTTTGTTTCTCTCGATATATTCATAGTAACGAAATGTTAAGCATTTTTAATATTTGTAACGGTAGTGGTGTCCGTCTATTAGGGTGCGGTTATGCGAACTAAGTACCACAACCCTTATTTTGCGAGAGCTTTAATGTATTGTATAGGTAACAGAGGTAGTTGAGCGCAGCCGAAACTACCCCTGTTACCTATGGACAACTACCAGCTAGTTCTGGAAATTTCTCATCTTGTGCGTCAGAAACCTCACGAAATTTATTACGGGAAATCTCGATTGCTGCTTTGGTATGTTCTGCTGTAAGTTGATGAAATTTCATATACTCAGCCCCGGCTATTGCCCCCTGTAGACTGGCATAGGAACCTGTGGAAGCACAGGCTCGAAGTAATTTCATCTGTGCTTGGGTTTTACCGGGAAAGGTGAGCTTTTCTGAAGCTTTAAAGGCTTTTTTGTACTCAATTATAGCTGACTGAAAGTCAGCTTTTTGCTCAAACCTTGCTCCTTTGATCCAGCGATCGCTTATTTCAGATCCATACACACAATTGGTAGTAAGTTTACACTTTACTGTTCTAGCTTCAGCAGGTTGAGTTTGAATGCACACAATTGAGCCTAATGTCAAAGCAGAAAATAGAACCAGCATTTTTAAGTTTTTTATCATATCAAATTTTCACAAATTAATTGAATGTTAATGAAGGCAGTAGGCAGCGAAAAGTTTTGTGGACGGAAAGCCGTCCCCACAAACTTTTCAAGACAGTCCAAATGAAAAAAAATTCATTAGTATAGATGCAACTGTCTTTTTTATGAATCACAATTTAGCGCCAAAAACCTTGAGCATACTCCGAGTAGACTTCATTGCCCAATCAGTTTGACTTTTCCGCTCTTTGGGGGTGAACGTTGTTTTGATCATGTTATAAGCCGGGGCAACAGAACCCACTTCTACTTCTGCGATCAATTTTCCGTTTTTAAATATCCAAGCTTGCCCACTACCTGTATCTCTAAAGGCAAACAGCTTCCCACCATAAAAATAAGCTGTTGGTCCATTATCGCCCTCTGGTCCTTCGATACTAACTCTGGTATGAATATCTTCCATTCGGCATAGTTCATATTTCAGCCCATCAAAGGTACGTTTTTCTGGACGTACACAATTTTCATCCACAAAACTAGTGTGTCGATCAAATTCCTGTTTAAAAGTGAGTTTGGGCTTGGCAGCAAGGGTTGATTTTGTTACTGTTTGAGCCTGCACAGATGGGATATCTGGGTAACTAAAAATACATAAAATTCCCGTAACTGCCAGTAGCAGATGCGATCGCTTGAGCATAATTGTGTAGATTTCCTAATTTCCTCTCTCCAGAATAAAATGGTTTTTGCTTTGATTCTTCGGTGAAATTACTTCATTCTAAGCAATTTGCGCTTAACTACTAATCTACCAAGGAAACATTGGCGCTCTTAATGAAATTTGTTACCGATTACCGATAAATGATTCTCAAGTAGTTCCCTGCTAACAGAAAAATTTCAGCCAAGTAATAACCTAAAAACAGCGCTACAGAATGCCCAAAAATGCCCAAAAATTTTGTATGACTTCGACACATTCTCAAAAAGTTTTAAAAATGCTCAATGATCGGTTATTGGCAGCTTATGAAAGATACTACGGAGATTTGAAGGTTGGGGATATGTCTCCTGAAGAGTTTATCACAACCTACGGACGCATTGAGGATCGGGTTAATGGCAATTTAAAAGTCGGGGTAATGCTTCCTGACGAATTCACCTCTACTTTCTCGACAAACTCAACTAATGCTGCACGCAGTTCTAAATCATCCAAAGATTCCCAGAATGTAGCCTGAGAAGCAATTGTTATCTGCTTCTGGGCATTTTCAAAAGCATCCCTATCAACGATTTTTACAGGGGTTGATAGGCTATTTATTGTTTCCTCTATTTTAGCGATCGCATGAATGATATCAGGGTTGGAACTGCGAAGTCCTCGCATCACCGACAACTCATTACTTAAGTTTTCGATTTCTTTGGTATTCACAATTACTGTCGTCACTGATTGACTTTGTAAATGATCAATTAATTGCGGTGCATGTCTGCATAGTTCTGTAATGGTCTGAGCAATTATTTCCCGCAGTCGGGTACATTTGGAATTTTCACAATGATATTTTCCCGGTTTACTGTAATTCGCGCAACGCATATATTCGGTTTTGGTTTTGTGACGGGAAAAGTTCCGATACATCCCTCCCCCACAATGAGCGCATTTAATTAAACTGGAAAGTGGATAGTCGCCACGGGTTGATGTTGCAGAACTGCGATATCTGCGATTCGCTGATAACTTCTGTTGAATTGCCTCTACTGTTGCAGCGCTAACTAAAGCTTCGTGAGTATCAAAATTAATTATGGGCTCTCGGTTAACACCTTTTTTCTTCTTGACAAAATAAGCTGTATGCCCTTGTAGAGCCAGGTTTTTTACCCAATCTCGCAAACCAGCGACGCTAAAAACTATTTCATATTCTACGTAAATATAGGTGCAAACATCTTTAAGCGATCGCATCTCTAAAATTAACTCGATAATCAGCTTCCCTAGTTCAAAATAGGTTTTTCCCGATTTCTCATGAATATTCCGATTCGGAACCAATCGCTGATTTTCGTCTTTCCCGTATCCAAATGGAGGAGTACAAAATTTGAGTTGCTCACGAAAATAATTATTTCCATGCTTAATCCTCTGGGATAACAGCCTCGATTCAAATTCTGCCAACCCGGACATTTGATTAATACTAAACCACCCAAAAGGTGAATTAGGATCAACTGGTGCATCTAATACCCTAAGATTAACCTCATGCTTTACGAAAATCTCGATCGCCTTATGAATAGTAATCACACTCCTACCCAAGCGATCGACACGAGTGACAATAATTTCATCAACTTGATTTCGTTGCACCAAGTACAGCAACTCATTAAATTGTTTTCTCGAATCACTACGTCCTGACTCAATATCTATCAGTATTTCCGTTGCACCCGCCGTTTTTAATCTAGCTATTTGCTGATTTAATGCATCAAATTCCTCAGCTTGTTCTTGCGTGCTAACACGGGCATAACCGTAAACTCTCATAGGAATTTTGGCAACTAGTTTAATTTAAATCAGTCCCAAAATCATATCATAAAAGGTGTTGTTCTAAATGTTTAAGTTCTGCTGTACCAACCACATATTCTAATAAAGTTTCACCCCCAATCCGGTTTCCAAGGTTCTTACTTCCTACAAATCCAGGTGAATTAACTGGAATGACTGGGACTCCAATTTTTTTCGCTGCCGTCTGGCACACTGCATCCAAATCCTCGCCGATGAGCGCGGTGACACAGGTCGAGTAAACGAATATGGCTGCCGGGTGATAACGCTTATGGATATCCATGACAGCTTTATAGAGCTTTTTTTCTCCGCCGAAGATAATATCATTTTCACTTAAGTCGGTTGTAAAGCCCATTTTATATAGCATCGAACCCGACGAAAGACTGCCACGACTCCCCCAGGAGTTGCCAGCACAAGCAATCGGTCCATGAACTAAATGAGCAGCATTAGTAATTGGGACAAGGGCAATCATTGCTCCATCAAACGCACAACCCCCCTGTGCTGCTCCAGGTTGTGCTTGTTGAGTACATGATTTATTTTTTTTCTCACCATTTTTTTGGTGATTATGTTCGCATCCAGGTTCTTGAAGTAACTCGTTAATTTTTGCTGGGGTAATCTTCATAGTTTTTTGCTGCTAGATGAGATAGTCTAATTTTTAGTGGCTAATCGGTGATGCTTGATTCTTAACTTAATGTCTAAAAATAATCATGAATAATATGCACTCCCCAAATAATTATATGTTCCCGTAGGATGTGTAAAGCCCTCCAGGCATGGCTAAGTGCAAAGTACACGCTACGCGCACGCTAGAGAACGGAGTTCGTAACGCACCATTCTCCACGGTTTAGTAGTAGTGATGATCATGTTGGGTTACATTCCACTTCAACATCATCTGCTACAACGGGTGGTAGATGGGAAGCGGCTTCTGTTGGCGTTGGCCCTACAGCCCTGCGGGCATCCTACGGCGGGCGTGGCGAAGCCTCAGCCGCCCTGTAAGGGCTAAGTACAGTCGCAAAGCAATGACTCCCCAACCGACAGAATATATCTTTTCGAAAACTCCAGACTTCAACATGAATGAGTTTCAAATAATATTTTCGATGCCTTCATAACACCACCCAACACCCTGTGTAAATTCCCATACAAATAAAGAAAAAAGGTCAAGGAAAGACAGATAAAGCTGAAGATGAAGTATAAAGTCTGATGCATTATTTTAATTTTTAGCATTCATTCTCTATCCTTCACTCTTCATCATTTATCCTTTTCCTTTTCCTTTATTGGCACGCCACGAGTGATGCGATGTAACTATTAACGGATCAAGTCAAAAGAGATATCTGTCTTACCAGCAATATCCGAAGAACGATCCAATTCATCAAGAATGGTGTTAACAACCCAATTGAGTAAGTTCAATCCACCTTTATAACCAAGAGTTGCATAACGGTGTAAGTGGTGGCGATCCATCAAAGGATAACCAATACGCACCATAGGAATCTTGGTATCACGCCACAAGTACTTACCGTAGGAATTACCTACGAAGAAGTCTACAGGCTCGGTGAATAGAAGAGAACGCATGTGCCATAAGTCTTTTTGAATCCAGACTGTAGCACCTTGACCAAATTGGCTAGCCTTCAAAAGTTGTTCCATCTCAGCTTTGAAGGTTTCATCACCATTGTTGCAAAGGATGTGAACTGGTTCAGCACCCATTTCTAACAAGAAGCTAGTTACACCGTAGATCAAATCTGGATCACCGTAGATAGCAAACTTCTTACCATGAATCCATGCATAGGAGTCAGTCATCGCGTCAACTAAGCGACCACGTTCAACTTCTAATTCTTCAGGAATGGCTTTACCTGTCATTTCTGACAACTTCATCAAGAATTCGTCGGTACCTCTGATACCCCAAGGACGGAGAACGCAGGTATCTTGCTTCCAGTTTTCTTTGATGAATTCACGAGTTTTAGGTGTGGTGTAAGCTTGGAGAGCAACTGTAGCTTTAGCATTACAAGCATCAGCAGCATCTTCTAGCTTGGTTCCACCGGGATACATCTCGTATTTACCGTTGTTAGGAGAATCCAAGTAATCGCTGTTATCAGCTAAAATTGTGTGGTCAATACCCATCAAACCCATCATCCGTTTAACTTCACGGTTGTTCTCGGTGTAGGTATCAAAACCAGGAATAAAGTTGATTTTACCATTGCTGCTGCTCTTCTTTTTACCTTCTGTTAAGGTTAAAAGAATTCCCTTCATCATGTTGTCATAACCAGTGATGTGGGAACCAACAAAGCTAGGAGTGTGTGCAAAAGGAACAGGCATGTTTTGAGGAACAGCACCAGCAGCTTTGGCATTACCAATAAACGCTGATAAGTCATCACCAATAACCTCAGCCATACATGTGGTGCAGACTGCGATCATTTTTGGTTTGTAAAGTTGGTTAGAAACTTGCAAACCTTCAACCATGTTGTTCAAACCACCGAAAACCGCTGCATCTTCAGTCATTGAAGAAGAAACTGCACTAAACGGTTCTTTGTAGTGACGGCTAAGGTGAGTCCGGAAGTAAGCAACACAACCTTGTGAACCTTGAACAAAAGGAAGAGTTCCTTCAAAACCAACAGCAGCGAAAATCGCGCCTACTGGTTGGCAACCTTTAGCAGGGTTGATGGTTAAAGCTTCGCGGGCAAAGTTCTTTTCGCGGTATTCCCAACCTTTTGTCCACTCAGAAACACGTTCAACTTCTTCAACAGAGTGTCCACCTTCAAACTGTTCACGCTTATTCTTGAACAGTTCTTGGTATTCTGGCTGTTTGAATAACTCAACGTGATCTACAATTTTATCTGGATTTTGTGGCATTTCTCTCTCTCTACTTTTACGTTCTAGATGAATTTATTTCGGTGCGGGGAATAAAAAGAGGGAAATCACGAAGGCAAAAGATAGAAGATAAAAGGTATATTTGCCTTCTTGCTTTTAACTTTTACCTTCTTATCCTATTTTTTATTCCCCAATCCCTAATTAAGCAGCTTTAGCAGCAGTTGCTTTCTTTTTCCAAGGAGTTGGAATCAAAGCCCAAGTAGGACTGTTGAGCGCCATGTCCATGTCACGAGCGAAGATAGCGAAGCCATCATAACCGTGATAAGGACCGGAGTAATCCTTTTTATGCTTATTCTTCTTTGATGATTTAAGGGTTAGTAAATAACGTTTTTTAGCCTGCTTATGTTTACGAATAACAAAAACATTTTTAGACTAAATATAGGCTAAATCAATTAAACCTAAAGCAAGATTTTTTAGTGTCATAAACCACAAATATTATTTAACAATATGAGAAGTCTTACGTCTATCAAAAATTATCATTTTACGTTCTATATTTCGTGAATCCAAAACAATACATGCAAAGCCAGATACACCTAAAATTGATAGAAGTTAATCAACGTTTGAAATCTGCAAAAACGAAAGTAACAATTAGAGAGTCAAATGGTAGTCTTCAATTAAGAGCAACCTTGCCTATCAAACCCGGAGATCGAGATGTTAACACAACGAAAAGAAAGCAGTACAATATCAGTTTAAATATCCCAGCCAATTTTGAAGGATTAAAAACAGCAGAGGAGGAAGCATACGAACTAGGAAAATTAATTGCTCGTCAAAACTTTGAATGGAATGATAAATACTTAGGCAATGATTCTCTGAAAAAAGACTTCAGTACAATAGGAGAATTATTAGAACGATTTGAAAAAGAATATTTTAAAACTCATCAACGCACAACAAAAAGTGAACATACTTTTTTTTATTATTTTTCTCGAACAAAGCGATTTACTAATTCAACTGATTTGGCAACTGCTGAAAGTTTAATTAATTCAATTGAACAAATTAATCAACAGTGGGCAAAATATAATGCAGCAAGAGCGATATCAGCATTTTGTAGCACATTCAAAATTGCCATAGACTTATCTAAATATTCTAAAATGCCCGAAAGTAATTCCCGTAAAATACCAACAGATAGAGAAATATATGCAGGGATTGCTAAATTTGAATATTATCAAAATTATAGAGGTAAACAGGTTAACCAAAATGTCCAAGATAGTTGGCAACTTTGGCGATGGACTTACGGAATGTTAGCTGTATTTGGTTTACGTCCGCGAGAATTATTTATTAATCCTGATATTGATTGGTGGTTAAGTTCAGAAAATGTAGATTTAACTTGGAAAGTCCACAAAAATTGTAAAACTGGAGAAAGGCAAGCATTACCACTTTATAAACAGTGGATTGAAGACTTTGATTTAAGAAATCCTAGATATTTAGAAATGTTGGCAACAACAATCAATAAAAAAGATCAAACTAAACATGCAGAAATTACTGCTTTAACGCAGCGAATTAGTTGGTGGTTTCGGAAAGTAGAATTAGATTTTAAACCCTATGATCTTCGTCATGCTTGGGCAATTCGAGCGCATGTTTTGGGAATACCAATTAAAGCAGCAGCTGATAATTTGGGACATAGTGTACAGGTGCATACACAGACTTACCAGCGTTGGTTCTCGCTGGATATGCGGAAGTTAGCAATAAATCAAGCTTTGAGTAAAAGAGATGAAGTTGAAGTAATGAGGGATGAGAATGGAAAATTGAAAGGTGAAAATGAGCGATTGAAATTGGAGGTTGAAAAGTTAAAAATGGAGATTCTTTATAAGCATTGTTGAAGATAGCTAAATCCGACTATTTTTCTTTGTCATGAAACAACATTTAAGCAAGCAGACAAAATTAATGTATCACTGAACCTGAATATAAGTTTGGATGTAAAGACGTAACAGTGCTACGTCTAGATGATTATTTAATTCTCAAAAGTTATAGCCAATTCCTAACTGCACTCCTACCTCAGTTTGCTGAAACAAACCAACATTAACCGCAGTCGTTGCCGTAAAACTACGTGATAGGGGTATGTCAATTCCTCCAGTCACTAATCCCCGCACATTAATATCTTCAAAGTTAGACTTTGCCCTTACCAACATACCACCTCCAATAAAGGGAACAAACTTAACTTGACCAGATGATGTTTTAACTGGAAAATTAGCAGTCAAGGCAAAGGTGGAGTCGTTTTTGTCACCACCAAATATGTTACTACCTCTAATTGAGAAGGAATCACTCAGGTCATTCTTTTGAAAAATGGTTATTCCCCCGTGACTCAACCCTTTCCCAACACCATTTACCCCAATGGTGCCACTAATGCCGATATATCTCCGCAGAGGCTTTTCTTTCTCAATTGAGGGTGCATCGGATGGCATTACAGTTGGAGAAGATAAAGGTTCGTTAGAATTGGGAGTAACATCACTGGGAATATTTATTGAAGGCAAAGATTGGGCTTGAATTGATCGATTGTTCAGGGAAAGTACCAGGGTAAAACCAATAATCACAAGGATAAATTTCATGGAAGTAGCATACATAGAAATGTCGATGTTAATTTTATTAGTAATTGTCTGTGGGAGGCGATCTTCGCCAACAAGTTAGAAAATCTAGAAAATATAAACCTATATTCATACAAGTGATTATTCGTTTTTAGTAATGTGTAATTAAGCCATCTTGGAGGTGAATAATTCGCTTTGTTTGGGCAGCAATATCAGATTCATGGGTCACAATTACAATCGTAATTCCTTGCTCGTTAAGTTCTGTGAGTAAATTCATTACCTCGTAGGAGGTTTGGCTATCTAATGCTCCTGTTGGTTCATCAGCGAGAATTAATGCAGGTTGATTAATTAATGCGCGAGCGATCGCTACCCGTTGTTGTTGTCCTCCAGAGAGTTGATTGGGACGATTCAAAATGCGCTCCCCTAGTCCTACTCTTGTTAAAGTTTGAGTTGCTTTTTCCCGACGCTGAGATTTAGGAATATTTGCATAAACCATAGGTAACATGACATTTTCTAGTGCGGTAGCGCGAGGCAATAAATTAAATTGTTGGAATACAAAACCGATACGTTGGTTGCGAATATAAGCCAGTTCATCAATGCTTAAAGTTGTCAAATTTCTATTTTCAAGAATATAGTTGCCACTACTAGGACGATCTAAACATCCCATAATATTCATTAGTGTAGATTTGCCAGAACCTGATGCACCCATGATTGCCACATATTCGCCTTGCTCGATTGCTAAATTAACACCTTTGAGTATGGGAATATTGACTTCGCCTAAATAATAATTTTTGGTAATATCTTCTATTAAAATCATATAAATTTTCAGGATGAATATTTGAGGCATAGTAACTATATATAGGACTCCTATTTGATTTCTGTTGGCGTAGCCTGCGCTTGCGCTTACAACCAAGTTGGTTATAAGCTTGCTATACAAAGGTTTATTTCTCAGTCTACTTAGCAAGATTCAAGTAGGATTCCTATAGTTACTATTGACTAATCGCTACGTAAAGCAGTAATTGGATCTAAACTAGCAGCATTCCGCGCCGGAATCACCCCAGAAATTAGTCCCACAGCACCCGATAAGCCAAAAGCCAAAATAATCGAATTAGAAGAAACTACAAACGGAAAATTAAAAGCTGTTGCAGCGCCAAATGCAATAATAATTCCTCCTCCAATCCCAATGACACCACCCACACAAGAAATAACAATTGCTTCAATCAAAAATTGATTGAGAATCGCCGAATTTGTGGCACCAATTGCTTTACGAATGCCAATTTCCCGTGTTCTTTCCACCACTGAAACCAACATAATGTTGGCAATGCCAATTCCACCTACTACCAGAGAAATTCCTGCGATCGCACTCACCATCAAAGTCAGTAAACTCAAGACAGTAGTTAAGGTTTTTAGTATGTCTGCTTGGTTGGTAACGCGAAAATCATCTATTTCGGGAGGCTGGATATCATGACGCGATCGCAGTAAGTTGGTAATTTGAAATTCTGCGGTTTTTATTTCTTCTTTTTTCCCGTATTTGACATAAATACCATTTACTGAAATCCCAAATAATGAATTATTTCCGACAATTCTGGCTGACATTGTTGTTAGAGGAATATAAACAGCATCATCTCGATCCATTGGACCTTGGGAACCTTTGACTTCTGTCACTCCGATGACTTCATATACTTCTCCCTGAATCCGAATTTTTGATCCAATTGGATTAATATTTTCACCAAATAATTTCTTCTTAACCGTCGGAGCAATTACTGCAACTTGTCCAGAACTATCTAATTCTTCTTGGTTAAAATATCTACCGGTTTCTGGGAAAGTATTTCTCGCATCCGGGTAATTTAAATCTGTTCCATATACTGTTGTCGAGGTATTTTGTCCTTCATAAACTACTTGAGATTTACTTTGTAAATAAGCAGAAACAACTTTTGCTGAGGGTGCTTCACTAGCAATAGCTTTTGCATCTTCCCAAGTTAAGGTAGTAGTTGAACCTAAACCTTTACTAATATTTCCACTTTTAGATTCACCTGCTAAAACTTGTAAAACGTCCGAACCCAAGCCTTCAATTTGTTTTTCAGTTGACTTTTGTACTCCTTCCCCAATAGAGGTAATCGCAATTACAGAGGAAATACCAATTATCATTCCTAACATTGTCAATCCTGTGCGTAATTTATTACTCCATAAAGATTCAATTGACATTGATAGTATTTCTAAAGAGGAAACAGAAGTATGCTTTTCTCTGGAAGTTAATTTCATACTCTATATAATTTTTGTATAATTTAATCGGAGATAATGACTAATTAACTCTCTTGTTTAGGTGGAGTAGGCAAGAAACCGCCCGATTGAGGTTTAGCGGCTTCTGGTGGTAGAGTTAATAACACCCTTTCACCACCTTTCAAACCAGACTTAATTTCAGTTTTATTGTTGACTGCAACACCAGCTTTAACTGGCACAAATATAGACTTATTTTCTGTATCTAAAATATATACACCTGTTCCTCGCTGATCGCGGATAACTGCAACGTTAGGAACTACTAATGCGTTTTCCTGTTGACCAACTTCAAATTCAACTTCCACATTCATCCCTGAACGTAAAAGATTTTTATTATCGGAAGTAATAGCCGCTTTGACTTCAAAACTAGTAACATTTTGTTCCACATCTGCTTGAGCAGCAATCTGTGATACTTTTCCCATAAACACTTTATTTGGATAAGCATCATTTTTGATTTTTAATGTTTGTCCAATCTGAATTTTAGCTAAATTTGATTCAGAAATATTTGCCACTACTTGATTATTAGCAGTCAAAGATAAAATCGAAGATGAGACACTAGAAGAACTTGCACCTCCAGCATTATTTGGAGTTACAAAAGAACCGGGATCGGCATATTTTTTAGTTACTACTCCATCAAAGGGAGCGCGAATCACTGTATCGTTAATTTGAGCTAAGATTGTCTGCAAAGAACCCCGTGCGGAGTTAACTTGCGATCGCGCTTGGTCTATATCCTCCTTTCTTGCGCCATTTTTGATTAAATTATAAGATTGTTGTAGTTGTTTGACTTTTGCCTGTGCTTGTTCGATATCTTCACTACGAGAACCAGTTTGTTGCAATTTCAATGCTTGTTCTGCTTCTTGAACCTGTGCTAATGCAGTATCCCTATTTGTTTGATATGTACTAAAACTTTGGCGAGAAATTGCCCCCGAATTTAATAACTCTTGATAGCGTTTTAAATCTGATTCTGCTTGATTTAGTGTGACTTTTACTCTTTTTAATCTTGCTTCTGCTTGTGCTATATCTTGAGGTCGATTCCCGGCAATTATTTTTTTGAGATTTGCTTGTGCTTCTTCTAACTGCGCTTGGGATTGACTAATATCTTCAGCACGATTTCCAGCAATTAATTTATTCAAATTTGCTTCAGCAGATGTAATTCCTGCTTTAGCCTGGGTAAGTTGTCCTTGTAAATTAGAATCATCCATGTAAGCAATGATTTGTCCTTTTTTAACAACATCACCTTCCTTTACTATTAGACTTTTGATTATACCTGCATTTTTAGGACTTAAATTAATTGAACGTTCAGCTTCAATTTTGCCATTGGCTGAAACCGTAATATTTAAGTTTTGTCTTTCAACTGGTTGAGTTGGTAATTGAGTTTGAGATTTTTGTCTTGGGTTCATGAGTAGAAAGCGAAACCCAGCAAAAATTACACCAATCAAGAAAGCGAAAAATAACAGCTTAATCGACCAATTACTTATATTTTTTTTGTTAATTCCAATACTGATTTTCGTCGAGTCATTAATCGAGCTTTGTGCGTCCATTTTCATATTTAACAAATTAATTAGAGATTCCCAAAATCGTGATAAATAAAATTACAAAAACACAGAGATAGAAAAAAGAAAAATAAATATATGCTATCTACTATTTCCATCTCTGTGATGATATAATCCTGGTGTAATGTGATTAACTTGCATTCATAAAATAGGGAGATAAATGCACAATGGGAACAACATTGTCACATCTCTCCTATTCTTCAACTCACTCTAGCCATGTAATAGGGTCAACGATTATTACCTACGAAATCCAAATGGGGTTCCACCACCTTGTTTTCGCATCATTGTCTCCTTAAGTTTTTGTTTTTGCTCATTTGTAAGGATACTAAATAACTGATCGCGTTGCCATCTTTGGACACCTTCCATTTGTTGCTTTTGCTGTCTGGATAAATTTAAGGACTTCATCACCTCTTGAGGATTTCTGCCTGTGTTCATCGCAGTTTTTAAATAATTTTGCTGTTCAGATGTGAGAATTTGGTTCATGCGATCGCTCATTTCCGTCTTCACCTCCTGAAGCTTTTCTTTTTGATCGTCGGTGAAATTCATATCAGGTATATTTTCTATCCCCCCTTGCATTTGCATATTTCCTGGTGGTTGAGATGGAAATTGTGCGTGAGAGATATTCGGTGTCGCACCCAAAATAATTATTGTGGGAACTAACGCAGAGATGACCTTCGTTTGCATTACTCTTCCTAATCCATTTTATTTGTATTCTTGTTACGGAACCTTTGATTCCATGCACTTATCGTATAAGCTATAATTCAAAACCACATGGTACTAGCGCTCTAATTTCATCCGGTACTTTAGTCCTAGTTAGAAGTGGCAGAAATAGTACTAAAGACTCTGGTGCTGACCTTTTAATATAGATTTAATTAGATTTAACACCATGATTCATGCCGTGGTTATTGATGGATCGGCATAGTTCACGATATTGAATAATTGAGATATAACAAATACTATATTTATTTGTTAGGCAACTATCTTAATATTAAAATCTTATCCATTATCATTGAATTATGTCAATCTTTTTGTAGTCTCTGAATTTTTATTTAAGAAATAGCTAAAATTAAAGCAAGCTAAAAATAAACTAGTTTAAATAGATATATCTTTTGTCTTAATTTATATGAACATAGCTCTGAAATTAAAAAATAATCTAAAAATAGAGCAGCACCCACTGCGTTTACTTCTATATTTAGAGTGGGTTTTACTTGGTATATCTATAATTATCATGAATTTACCTCCCGCACGTTTAGTGGGAGAAACAGAACGCGCAAATCCAATCCTATTAATTGCTAGTATCACAATTTTGGGGATTATGGGCTTAAGGTTGCCAAAGGGCAATAGATTCTCAAAAATTATCTATATATTTTTACAATTGCTATTAATTTTATTAGCAAATATTGGAGTAGGTGATATTGTTGGGTTTTCGCCTGGATTGTTATTAATTGTGGCAATTCGGAGTATTTTAATATTCAAAATATCTGAAAGTGTAATAATTATTGGTTTAATCTGGATATGTTTTATTTTTACTTTGAATACAATCAAAATTCCACCGAAAGTCCCCATAAATCCCAATGAAGGTTTTATCTGGATTGTCAAATTAAATGTTTTAATGCTATTTAGCTTAGTTTTAATTTTTGTTCTCCTTTTAGTAAACGCATTATTTTCAGAATTGAAAAGTCGTCAACAACTTGCCCTTGCTCACGAACGTTTACGAGAATATGCTCTGCGTATCGAAGACCAAGCAACATTACAAGAACGGAATCGCATTGCCCGTGAAATACATGATGCTTTGGGACATTCATTAACAGCACAAAGTATTCAACTTGAAAATGCATTAGTATATTTAGAATCAAACTTGGAAAAAGCCAAAAGTTTTTTATTAGAAGCCCGAAAACTTAGCGCTAATCTCTTACAAGAAGTTCGTTGTTCAGTAACAACATTGCGTTCTGACCCTTTGCAGGGCAAATCTTTAGATGCTGCAATTCAGCTTTTAATTGTAGATTTCCAAAGTAGAATGCAAATTAGTCCTAATTATTCTTTACGTAATAACTTATCAATTCCCCCGGAATTAAACAGGACGATTTACCGAATTGTTCAGGAAGCTTTGACGAATATTTCTAAGCATAGTGAGGCAACAAAAGTCAAAATTGATATACAGACAACCAAAGATTCCTTTCTTGTCCGTGTAGAGGATAACGGTATTGGTTTTGATCTTAAACAAAATACCACAGGTTTTGGGCTGCAAAGTATGCGCGATCGCACGAATGCACTAGGGGGACAATTTTATCTCAACAGTGAACCAGAAGCAGGTTGCAGTATAATGGCAATTTTCCCACTGTCGAGGCTGGAATGATGATTCGATTACTATTGGTTGATGACCAATCGATTATTCGTCAGGGTATCAAAAGTTTACTGGAATCTCAACCTGATTTTGAAGTAGTTGGTGAAGCCGAAAATGGCAAACAGGCTATATCTCAAGTCGAAATTTTACAACCAGACGTAGTTTTGATGGATGTGCGAATGCCAATAACAGATGGTGTCGCAGCAACAAAAGCTATTACGCAGCAATTTCCTTTAGTGAAAGTTTTAATTTTAACTACTTTTGATGATGATGAATATATTTCCCAAGGAATGCGATTTGGTGCTAAAGGTTACTTACTTAAAGACACACCTTTAGAACCTCTAGTAAATGCAATTCGCTCGGTACATTCTGGACATACTCACTTTGGTCCAGGATTATTTGAGAGAATCATGACTCCTACTGTAGAACGTACATTAGCAAAAACTTTTACTCGACCACCTGAGTTAGAACAATTAACTCCCAGAGAAAAAGAGGTTTTACAGTTAATAGCTTCTGGTGCGAGTAATCGTGAAATTGCCGAATCTTTGTTTATTGCAGAAAGAACCGTAAAAAACCATGTCACTAATATTCTCACAAGATTGAATTTAAGAGATAGAACCCAAGCTGCTATTTTTGCTAATTCATTTAGTTTTGAGCAGTAAAAGCATTAAAACAATTTCGTTTAAACCCTGATGATATCTAGTCCTCACCCTACGGATTACTTTCTCTTTTCCTATTCGTCTTTTTTCCTTTAACCGAAAAGTATTGCCTATTACCCGACCTTGGGTAGATGCTTAGAGTTTACTTTATAATTACTATAAGAAGTATATAAGTAAAAAGTTTTTCAATTTAGCATATTATTATTTAAATAAGAGATATTTTTTTCATTTGAAGCCCGTAAATTTATTTATGCGGGTTTTGAATTTTGAATTTGGAGTAAAGCAACGTGATTCAATCAATCGAGAATACCAGAATCGAAACAGTTAATACAAGTAGACAGAATGAAGAACAGCCAAAATTAGGTTTTTGGAAAAGTTGGCAAGCAATAATAGAATTAATCAGATTTATAGATGAGGAAGAACCAGGAAGATAACAAAAAATAATAAATAACTGCAAAAATCGTACTACGTGCTTTAAGAATCCTCTTTTTTCTGTTTTTTATTAAAAATAAGGATTTCTACCCGTTGGGTGTGGGATAATCTTTTTTTCACACCCTTTTTTGTATTACAATGAAAGAAATTAATCTTCTTAGACGAAAAATATTCTGTGCCATCTAACGCCACTAAAATTTATCCATCTAAGTAGAGAAACTTTGACAAAACTCCCTTTTTCTCTAACCATTGATAGATTTTTTGAAAATTTCCATACCTGCATTAAACCTATGGCAAAGCGTAAAAAAGACGATCTCCACTGGGTTAAAGAAACTCTAGAACTTAAACCCAACCATGCTTGGGATTCTCCACCGGAGTATAAAATATTTGGGTGCGACTCTTTTAGTAGTACAAGGTATGGTATAAGAGTAATAGGAGACAAGTCAACCAGAGTAATGTTTCAGTGCAAAAATGAAACAGATGCATCCTTGCTTGTCAAAAGATAAAAACGGGAATAAGTACGGACGTATGCAAGCATCTAGATCAAATCCAGGGATGTTTTGGGAAGAAGCACGAGAACTATTTGAAGAAATAGTTGGTTGGCTGGACTCAGATAGTATTTGTGGGTTGGAGCATGGAGAAATAGAAAGTAAGTTGCTTGATAATGGATATGAACTACTTAGAAGGCTGTTACAAGGATACTTTGATAAGCGTAGCCAAGACGAAACGGATTCTGAGTGGGTAGGAAAAGACCAAGCCAAGCGAACGCACAAGAAAAAATTGTCAAGGAAATTAACAACAATATTTGGCACAGTAATCGCAAACCGAATCGGTTACGGAGGTAGAAAGATAAACACCCTATTTCCATTAGATGCAGAGCTAAACCTACCAGCAGAACAATATTCTCACGGATTAAGACAACGAGTAGCAGTGGAAGTAGCTCGTTCAGGATTTAGGGAAACAGTGGATATTATCGAAAAAACAACAGCAGCCAAAATTGGTAAACGGCAAGCAGAAGAACTAGCGTACCAGAGCGCTGTCGATTTTGATGATTTCTACACATATCAACAGGCAGAAGCGGTACAAGTTGAGGAAATAGGAGAAATTGTTGTAATCAGTGCAGATGGGAAAGGTGTGATTGTGAGCCACTCGACACGGGCTGTGCCCAGTGTCGAAGTGGCGGTGCGTACAGAGGATTTACGTCCCCAAACCCAAAAACGAGCGCAAGCTTCCAGCAAGAAGTTAGATAAGCGTTTAACCAAAGGAGAAAAAGCCAATGCCAAACGAATGGCAACGGTAGCTTCAGTTTACACAATCAACCCGTTTGTTCGTACAGTTGAGCAAATAGTTAACCCATCCGATGAGGATAAGAAAATAAAGCGTCCTAAACCTATTGGAAAAAGGGTTTGGGCTTCTGTTGCCAAGGAACCAGAAGTCGTCATTAAAGAGGCTTTCGATGAGGCATTGCATCGTGATCCAGATCGGCAAAAACGCTTTTGTGCCTTGGTCGATGGTAATAAGCAACAATTATCGTTGATCAGGACTTACGCAACTGTCACAAGCAATGGTGCGGCTACGCCGCACCGAGCGCCAAACAACCTAAAAGGAAAACATTGGAATATTGGGACGTTTTAGTTGTTGAACTAAATAATTTGACAACAATCCATGCTTAATTTTATAAATTGTTTGACCACTTTTATAAGCTAAATCTTTAAGTCGAAGCCAGACTAAAATAGCGCAGGCAATATGATTTCTTTGAATACGACCCTTACGACATTGACATGATTCAAGACCAGTCAATTGTTTTAACTCTCGGTGAAACTCCTCAACCTTCCATCGAACTTTACACACTTTTTGTACAACGTCCGTAGAGTCTTGAGATAAATCATTTGTAGCGATAAAATCCGTTTTGTCAGTGGAGACAGTTACCCGGAACAGTTTCACTTTTTTAGCTTGAGGGAACTTTTTTATTTTAACTATTTTACCTGATTTTAACTCCTCTTCATCCCAAGATAACAATTCAATTCTTTGATACTCTTCTTCGCCTGCCGTATCATCAACAAGTCGATTACGTTTCAGAGGACAATAATAATATTTCCCTAATCCATCAATATATAACATCAATTTATTTGTCGCATACCAAGTATCCATTAAGACAGCTTTAAATGGTAAAGCCTTATGATAAACAAGGTTTTGCAGCATTTCCATCACATGGTCTATCTTTGTTTTTCCATCTCTATCTGGATCATAAATACGATAGTCAACTACCCAAAACTTTCCAATTTCATGATTTACATATACACAATTTACTAACCCAATCCCTTGAATTACACCATGCTCGTTGCCACTATATTGCCGTCTACTTGGCTCTATTTCAGTAGCGTATCGTTTATCAATTACTGTGTCATCAAAAACTAAGTAAGCATTATCATTGATTTCTATTAAATCTTTCACGTTATCCCAAAGAATCCGAGGCGTTAATTTTTCGTTCTTTAAATAACGATTGATTTTATCATGACTGATCTGCTCTAAATGGTCTGCCAAATTTGTCAGAGTATAATTAATCTGACTACTTAACAAATACTGGCAATAGTTAAGTTTAGTAAATCTCATAAAGCTACAGGATTTATTTTATGCATCCCTAGCTAATTTTCTCATGATTTGATGAATACTTAACACAACAGATTACTGTTACGAATTTTCGTAATTTCCTTTGAGGATGCCACATTAATTTAGTACATATCTACTATAAGAATGTGAAGCTTGCTCAACGTAAGTCGTTCGCGCTGTGCCAGTTGCGTAAGTCCTGGTTGATGAAGAAATTTACCAAAAAACATCACCTCGAACTGACTATTGTCCTGGATATTATCCATGTGATTGAGTATTTGTGGAAAGCAGCATTTGTATTTTATTCCAGTACGGATAAACAAGCCGAAGCCTGGGTTACGAAACGTTTGAAGTCTATCCTTGAGGGGAAATCCAGTGATGTTGCTTCTGGGATGCGAACAAGCGCGACAAAACGTAAACTCACACCCCAAGAACGCAAACCTGTGGATAACTGTGCCAGATATTTGCTCAACAACCGCGAATATCTCAAATACCATGATTATTTAAAAGCTGGGTTGCCAATTGCTACCGGAGTTATCGAAGGTGCTTGCCGTCATCTGATTAAAGATCGGATGGATATTACTGGTGCCAGATGGAGTCTAGCTGGTGCCGAGGCTGTTTTACGGCTTCGTTCTTTGTATATTAGCGGGGATTGGCATAAGTATTGGCGCTTCCATTTACACCAAGAGCATAAACGCAATCATCTTGCTCTGTATCAAGGTGCAATTCCCTTGATGAAGCGAGTTGCTAAAGCCCGTTGCCCTATTACCCCTTCACCCCTTCCAATACCTGTCTAAACTACATTTCCTGTCTTACTAAAAGAGCCGCACCCAAAATATTTGTAGCTGGTCTGGGAGCAGTTCGCTTCAATGTTCCTGGTGATTGGATTTTTGAACCTCAGGAAAAATCATTCAAGTTTCGGGATAAAAAAGACGATTGCTGTTTGGAAGTATCTTACAATCACTTGCCGCCCAACGATTGGAATCGATTTCCTCTGAAGGCAACTTTACAGAAAATTATGGAAGACGATAGTCGTGATGTGGTGGAAAGGAGTGAGGTTTTTGTTGTTAAACGGCAAACTGCAAAGATTGTTTGGTGTCAGATGAAGTTTATTGATGTTCAGGAGGAACCACGGGAAGCTTTTTCTCGAACTTGTATTGCTTTGGGCTCAAATATCCAGTGTTTGATTACGTTCGACTATTGGGTTGACCAAGCCGAACAACTAATACCAGTGTGGGATGAAGTTATGCGATCGCTTACTCTAGGATTGTATATCAGTGACCCAACAACTGGTTTTGCATCACCTGACTAGCTAAGTTAAATTTACTACCCTATTTTAAAATATCAGTATTCACTACTGGATTCTCAAAATTTATAATTAACTACATGACTAACAACTGGATTCAAGTCAAAGGTGTCATTAAACCAGGATATGGAGTAGCATCTGGCAAAGGTGGAGATTCCCGTTTTCCCCAGGGAACAATTGCGATGCAAAAGCCTTTCTTCCAGAAACTGGGTTTAGATCTCAGCCCATATTTTATGGGAACAATCAATATTTCAATTCACCCACATCAATATACAATTATCAATCCTAAATATACATTTAGGAACCTGAAATGGTCATCGACTGAACCAGCCGAAGATTTTTCATTCCTCGACTGTATAATCGTACTTGCTGATGCGGCTCCTCTCAATTCTTTAATTTATTATCCACATCCAGAAACAAAACCAGAACATTTTCAAACCCCTGATACTTTAGAGATGATTGCACCTTTCATAACCAACTTAAAATACGGAGATGTGTTACTCATGGAATTAAATTCTGCACAAATTGCCATTGTCTAATTTTAACATTATCAATAACTCTACTATGCATACATTCAATTAGTCTAAAACTTATATAATTGAAAGTGTTTTAAAATTTACAGATATTTTTATATATAGATATAACTAGACTTTGAACTGTAGTTATAATTACGCTTTTCTAGAATTTCAATAAGATGAAATATGCTACTTAGTTAATATGAAAATAATTCTAGACTAAAATATATTTCCTAAAAAACAAACTAGTAAAAAAACCTTGTATATCCTAGATTTGAGACTCAATAACCAGGTTCGGAGTAATCCCAAGAGTGCATTTGGCGGAAAGGTAAGCCCATTTTTTGGAAAACATACTTTTCTTTAATACCAGAAGCAACTAAGTCAGGCTTGCTGTGCTTAACGAATTCTTCAAATTCGTATGCTGTCACGTCATCGTAAATAATAGTAGCATTATCTACGTATTCAGTGGTACGTTTGTAATCATCATTGTGTCCAAATTCATAACCTGTACCAACAACTTTGATACCGAGGTCTTCAAATGCAGGAACAACGTGACGGGGACGCAAACCACCAACATAAAGCATGACGGTGTTGCCTTCAAGACGGGGACGGAATTTTTTGAGGATTGCGTCCATGGTTGGTGTGTACTTAGCGATGACTTTCTCAGCATTTGCTTTGATTTTGTCATCAAACTTAGCAGCGATTTCACGTAATGATTCAGCAATCCGAGTAGGACCAAAGAAGTTGAATTCCATCCAAGGCATGTTGTAGGATTCTTCCAAAGTCCGGCAGATGTAGTTCATCGAACGGTAGCAGTGGATAAGAACCAATTTAGCAGCAGGACCTTGGATCAATTCGTTAATAGTTCCATCTCCAGACCATTGAGCCACTACCCGTAAACCCATTTCTTCTAGCAATAAACGGCTAGACCATGCGTCACCACCGATATTGTAGTCACCAATTAATGCTACATCATAGGGGCTTGGTTCAAAGCTGATTTTGCCTTCTTTTTTAGCTTTGTCATGGAGTGGGAATACCCAGTCACGGATAGCATCGTTAGCAATGTGGTGTCCTAAAGATTGGGATACACCACGGAAACCTTCACAACGTAAAGGTACAACTGGTTTGCCAATTTCTTTTGATGTCTTCTTAGCAACAGCTTCGATGTCATCTCCAATCAAACCAATTGGACATTCCGACTGAATGGAAACACCTTTGTGGAGTGGGAAAAGTTCTTCAATTTCGTGGACGATTTTGACAAGTTTTTTGTCACCACCAAACACGATGTCACGTTCTTGGAAGTCTGATGTGAAGTTCATGGTACCGAAGCTATCGATACCAGTTGTACCTACATAGTAGTTACGACGACCAGACCATGACCAATAACCACATCCTACAGGACCATGGCTGATATGAATCATGTCTTTGATTGGTCCCCAAACCACACCCTTGGAACCTGCATAAGCACAACCACGAGCGGTCATTACACCAGGAACAGATTTTACGTTAGACTTAACGCCACAATCCGACTTACCCTCTTCCATTACGTTGAGGTGTTTTTCCCGTTTTTTGCGGGATTTTTCGGGGTAAGCTTCAAGGACTTCTTTAATCAGTTCCTTATGTTCTTCAACGAGGTTCTTATTTTCTGGAGGTGTCATTCTTCTGCCTCTATTTATTTGTGAGTAGATATATTAGGAATAATGGAGTTTTTTTCAACTAGCGAGGAAAGAGAAGGTAAAAGTAAAAAGTTAGACTTTCTACTTTTCCTTTTCCTACCACATTAGTTATTTGCTAGCAGCAGCTTTGATTTCAGGTGCTGCGTGCTTGGTATCATCATCAAGGATACCGAACTCGATGAGTAGTGCTTCGAGTTCATCCATTTCAATAGGTGTAGGAATGGTGAGGTTTTTGTTGTTGATGATTTTCTTAGCCAAGGTACGGTATTCATTACCCTGATCGCTATCAGGTGCGTACTCGTTAACAGTCATCCGACGAAGTTCAGCGTGTTGAACAATGTTGTCGCGGGGTACGAAGTGAATCATTTGAGTGTTCAAGCGTTTTGCCAAGGTTTCGATCAACTCGACTTCCCGGTCAACTTTACGGCTGTTACAAATCAAACCACCCAAACGTACGCCACCTGTGTGAGCATACTTCAAGACACCACGAGCAATGTTGTTAGCAGCATACATCGCCATCATCTCACCTGAGGTAACGATGTAGATTTCTTGCGCTTTACCTTCACGGATAGGCATAGCGAAACCGCCACTTTCCGCTAACTACCACCAAAATTAATGGGACAGAGCACTAGTAGTGCGTCAAGAGCTAATTGACGGATAGATTTTCTTTAGAGCGGTTAACGGGGGGCTTCGCATCCCCCGTTATGGGTTAAAGAAACTTAAAAATAGAAATACAAATTTTAGGTATGCTGTTAGAAGCATTCAGACAGCCAAAACCGGAGCGTCAATGGTGCATTAATAGTCCGTTGTAGAGCGTGGTTCTGGGAGTAGAGATTATGAGATTGGTGAAGTAAATTATTTTGCTATCCCGCTTAGAAGAATTATAATTTTTAATCATTCCCAGGTCAGGATGCTTCTAATTGCTGGAGTTTTGGAGATGAAAAAGCAAGGAAAGAACAAACAAGTATCAGTTGGCGAAAAAGCTCAAGTGTTTTCACAAAAAGGGTTTGAACTGATCAATCCAAATGCAGCAGGTATAGACATAGGAGCAAGCGAACATTGGGTAAGTGTACCAATAGGCAGAGATAGTGAGTCGGTACGACGGTTTGGCTGTTTTACATCAGACTTACAGGCAATGGTTACTTGGTTGAAGCAATGCGGAATCAAAACAGTAGCAATGGAATCAACAAGCGTTTACTGGATTCCGATGTTTCAAATATTGGAGACAAGTGGATTTGAAGTACGTTTAGTAAATGCTCATTTCGTCAAGACAGTGCCGGGGCGCAAAAGTGATGTCCTAGATTGTCAGTGGCTACAACAATTACACACCTATGGGCTGTTATCAGGTTCATTTAGACCAGAAGACCAAATTTGTGTTTTACGTAGCTACATCCGTCAACGAGATAATCTGATTCGTAGTAGTAGTACTCATATATTGCGAATGCAAAAAGCTCTTCAAGAGATGAATCTACACCTCAATCAAGTACTAAGCGATATTACAGGTATTACAGGCTTAAAAATAATACGTGCAATAGTTGGGGGGGAACGTGACCCAAAAGTATTGGCATCGATGAAAGATTGTCGGGTTAAAAGCAGTATCACAGAGATTGAGAAAGCCTTGACAGGAGATTACCGAACTGAACATATTTTTGTTCTCAAACAAGAATTACACCTGTATGAAATTTATATTGCTCAAATTCAACTGTGCGATATCGAAATTGAGCAGTATCTAGGCAGCTTTGAGGACAAAAATGGAGATAAACCCCCCTTACCCCCTGAAAAAACTAAAAAAACTAAGGGTAACTCACCTCAATTTGATTTACGCTCTCATCTTTACCGTATTAGTGGTGTTGATTTTACTGCTATCGATGGCTTCGGTGTTTTAACTGTTCAAACCCTACTATCTGAAGTTGGGCTTGATCCTGGGCGTTTCCCAACTGTTAAACATTTTACATCTTGGTTGGGTTTATGCCCTGGTAGTCGTATTAGTGGTGGCAAAGTCCTCAGTTCAAAAACCCGCAAAGTTGTTAATCGTGCTGCTACTGCCCTACGGGTTGCTGCTCAATCCCTTGCTTCCTCTAAATCTGCTGCTGGTGCTTTCTATCGTCGTAAAAAAGCTCAACTTGGTGCCCCCAAAGCAATTACTGCCACTGCTCACAAACTTGCCCGCATTTTTTACCACATGTGGAAACATGGAGACACTTATGTTGACACTGGTGCTAATTCTTATGAGCATAAATACAAACAACGGGCTATTAGTAACCTCAAGAAAAAAGCCAAAGACCTTGGATTTGATTTGGTTGAACAGCCCCAAATCGTGGAAGTTTCTTAGAAGACAGCAATTTACCCCGTCTCTCTAACCGTCAAGATAAGTTTTACAGACTACTAGTTATGACCAAGGTTTGTAAATGCCCTCAAATACAGTCCTATTTAGACACTAACCTGGTAAAATAGTGTACTCAAAAAGGTTTCGATTTCCTTAATTTCATCATCACTTAAGCGGAATTCACCTGCACCGATGATTCCTTCCACCTGTTTAGCGTTGCGCCCACCAACAATAGCACCAGTAACCGCTGGATGTCTTAGCGTCCATGCGATCGCAACTTCACCAGGAGAGCGTCCATATAGTTCTCCGATTTGGCGTAGTAATTCAACTAGATTTAGGTTGCGCGAAAGGTTCGGTTCCTGGAATTTTGGGCTGCGTCGTCGCCAGTCATCATCTGGTAAATTTTTCACACGCTCTCGTGTCATTGCACCAGTAAGCATACCAGATGCCATTGGTGAGTAGTTGATTATACCTATTTTTTCTTGTTGACAGAATGGCAAAATTTCCTGTTCGACATCTCTATCTAGGAGGGAATAGGGTGGTTGTAAGGAGGTAATCGGTGCTATTTGTTGAATACGGCGCATTTGCTCCACATTAAAGTTGGAGACACCGATATAACGAATCTTTCCCTGTTTCTGTAATTCTGTTAGCGTAGTCCAGCCCTCGTCAATGTCAGCGTTGGGCCAGTGGATTTGGTAAAGGTCAATCACATCAGTTTGCAATCGCTGTAAACTCTCTTCAACTTCTCGCCGCAGAGAATCTGCCTTAAGGACGGTACTAACTTCACCCTTATTGTTCAAGACTTGAGAACATTTGCTAAAAATATAGGGACGATCAGACACTCCTTTAAGAGCATGAGCTACTACTTCTTCAGAATGTCCCAAGCCATAGATAGCAGCAGTATCAATCCAATTTATGCCCAAGTCAATTGCTCGTCGAATGGCATTTATTGATTCTGTATCATCTTGTGAACCCCAGCCATGAGACCATCCACTTCCACCAATTGCCCAAGCACCAAAGCCAATAGGTGTGATGTAAAGGTCAGAATTACCAAGTTGTTTAGTTTGCATTTATTTTTCCTCAACCTCAAATTGCCATAAAGTAATTGCCACTAAAGCGGTAGTTAGTATTTTGCTGTTAAACATCATAAGATTCCTGTTAATTACGTATTTTGGCAATGAATGATAGTGAATTCAGAAAAGTAGCGATCGCAAACTTGACGGCAATTACTTATACAGAGAAATGAAAAATGGAGTTTTGCGAAAACTATCGCCACAGTTACTCACTCTCTAAAACTGATAATTATTAACGCAAATTGGATGCTGTTGGCGCAAACTTTGCAAACAGCTTCAACATTTCCTGATTGAATGCGGGGATATCCTGCGGTTGACGACTTGTGACCCAGTTTTGATCTACGACAACTTCCCGATCTACCCAATTACCGCCAGCATTGCGAATATCATCTTGAATCGTATAGTAACTGGTTAAGGTGCGTCCTTGCACCAAGTTAGCAGAGACTAACTCCCAAGCTGCGTGACAAATAATTGCAAAGGGTTTATTATCTTGCTGCATCTGCTTAAGGAAGGATTGTACTTTTGATTCCATTCTCAAGGTATCAGTATTGAGTGCGCCACCTGGTAATAATACCGCGTCATACTCGCTTGGTTGTGCTTGGTCTATCAGGCGATCGACATTTACAGTTGTTCCTTTATCCTGATGCCGAAATGCTTGGATTTCTCCAGATTTATTTGAAAGAATTTCTACTTTTGCACCAGCTTCTTTAAGTGCTTTTACTGGTTCTGTCAGTTCAGTCTCTTCAAAGCCATCGCTTACTAGTACTGCTACTCGTAAATTAGATAAATCAGCCATAATAATCTGCACCTTTGAGCCTATATTTTCTGATGATTGGATTGAACCGAGCAATCCAACCCCCTTAGCTTATGATTTTGTTTCTATTTGAACCTTTGTCCTAAGGCATATTTTGTAGTCTGCGATCGGGAAATTTTCCAACTCTACTAATTGGATCTGTGCTGGACTTAAGTCTTTCTTCCACTCATTTTCTCAAGTTTGTCAATGAATCTGGATGGATATCGCTGCGTTGCCGATCCTAGTTCTCCACTAACAGAAATTTTTCGCCACTTTCCCCTAACTACACTAAAAAATGGGCGTTGCTGAATCAGGGGATGATTTCACTAAATTTTCAACGATTTTTCAATGGGTTCCAACGCTAATTCATCCCGCACTTATGCAACGCCAAAAAACGAAATGTCTTTGCGAAGCGTGCCGAAGGCATTTCAATTTGACATCGCTTGGAGTAAAGTTGTTTTACCAGTACCATTATCCCCCAAAACCAAAAAGCGAACGACTTACGTCGCGCAAGCTTCGCTGATTGTGTTCAGGGTTTGATTTTTGAAGGATACTTCAAGGTTGTCAAAACGCTTGAAGTTGTTGATCCGGATAGACTCAACTTTCATACAGAACCCCGATGAGCGCTACTGTAATAGGTTAACAGATAGTTCCACCAAATTACTTTCTCCAAACTGTCGATGAGATAATTTTAGCTTCCACATCATCTAAATAAAAATCATAAACAGGTTCTCCAGATAATTCACAACGAAGCGGCTCAATAATTTTACTAAACGGATTCCAAACTACCGTTACAGTTCGTCTTGCCTTCTTTCTTTGCAACTCACACTGAATATGTACCGTAGGTAAATTGATAATCATTGCACTGTGCAAGGAAGCCTGACTGCCTGACAGATTTGTTTGAAAAGCAGTCAAACCCAGGAATTAAAGGAGTAAATTCGAGAAAAGCATATTCCGAGATTGTCATCTTGACGAGCTTTATTGGAGGCAAAACTTGGTTGAGGATCTTGTGATAACAAAGGAATTGGGGTGAGTAATTGTCGTCCCTTGTGAATAACACCTTTGAGCCAGCGCAAACCAATCTTGAGATAACTTAAACCACGATTCCAGTGGGGGTCAACACAAGTACGTAAACCAGCAATTTGTACAGCCATGCCGTGGGTTGTACTGTAAAGTAAAGCTAAGGCGGCAATCAAATACAATCTCTCCAAAGATTCGGCATCACGAATGCGAGAATCTTCGAGTTCAAATGCACCTGATTTACTGTCCAGAAATAGTTCCTCTACGCAGAACCTCAAAGCATACTCATGCAATGTTTTTAAAGCTGGCTCTTCGTCTGTAACAACTGCCCAATGCTCGGATACCACTTCTGGATAGGCGACTACCAAATTACAGCGAATTAGGCAATCTTGCCACAGTCCAACGTTACGATAAAAAGCTGCTTGTCCTCGATTTGGATAAATTGATTTTACATGTGTTGGGTAACGTCTAACTCCATGCAAGCATGTATCACTTGGGATACGTATACAGTAATGCCAATTGCTTTTTTGCAACCAACTCAAGAAATCATGATTTGCAAAGCCCCTATCTGCAAGTATCATAATATCGGAATCACGGCGTAGTAACCACCTAGCTTTACGTAGCATCACCTCGTATTCCTTAAATGCAACCGTTGCACTGTTATGTTCCAATACTCTCCACAATAAAGGGATTGCTCGCCCACAACACACCACTGAGATGTGAATCATGCAGAAACGATTCCAAAGCATAGTTGTATCTAATGCCAAATACAATCGATGTTTTTCCCAGTCTTTGAGTGCCAACAATGCCAATGGCAAGTATATTTTTTCAACGTTAATCCTTATATTTTCAAGGAATCTATGCCACCTGCGCTCGTAGCTTTGAGCTTGTTTGGCATAACTGTCTACATATGGTTCCCATGCGCTCAAACTTAACTGACCACTACATATCAGCCCATTAATCATCCAAGCAAGAGTTTTTAAATGACGCAAATCACGGTAGGTACTGTATTGACGTAAGTATCCTAATACCTGACTATAAAGTTGGGTTGAGTTTGACAT

Protein sequences of DBSCAN-SWA_1

>NC_019751|249445:282790|259072_260611_-|WP_015195987.1|DBSCAN-SWA
MPQNPDKIVDHVELFKQPEYQELFKNKREQFEGGHSVEEVERVSEWTKGWEYREKNFAREALTINPAKGCQPVGAIFAAVGFEGTLPFVQGSQGCVAYFRTHLSRHYKEPFSAVSSSMTEDAAVFGGLNNMVEGLQVSNQLYKPKMIAVCTTCMAEVIGDDLSAFIGNAKAAGAVPQNMPVPFAHTPSFVGSHITGYDNMMKGILLTLTEGKKKSSSNGKINFIPGFDTYTENNREVKRMMGLMGIDHTILADNSDYLDSPNNGKYEMYPGGTKLEDAADACNAKATVALQAYTTPKTREFIKENWKQDTCVLRPWGIRGTDEFLMKLSEMTGKAIPEELEVERGRLVDAMTDSYAWIHGKKFAIYGDPDLIYGVTSFLLEMGAEPVHILCNNGDETFKAEMEQLLKASQFGQGATVWIQKDLWHMRSLLFTEPVDFFVGNSYGKYLWRDTKIPMVRIGYPLMDRHHLHRYATLGYKGGLNLLNWVVNTILDELDRSSDIAGKTDISFDLIR
>NC_019751|249445:282790|270268_270415_+|WP_015195996.1|DBSCAN-SWA
MIQSIENTRIETVNTSRQNEEQPKLGFWKSWQAIIELIRFIDEEEPGR
>NC_019751|249445:282790|281057_281249_+|WP_158333118.1|DBSCAN-SWA
MGSNANSSRTYATPKNEMSLRSVPKAFQFDIAWSKVVLPVPLSPKTKKRTTYVAQASLIVFRV
>NC_019751|249445:282790|263299_263965_-|WP_015195990.1|DBSCAN-SWA
MILIEDITKNYYLGEVNIPILKGVNLAIEQGEYVAIMGASGSGKSTLMNIMGCLDRPSSGNYILENRNLTTLSIDELAYIRNQRIGFVFQQFNLLPRATALENVMLPMVYANIPKSQRREKATQTLTRVGLGERILNRPNQLSGGQQQRVAIARALINQPALILADEPTGALDSQTSYEVMNLLTELNEQGITIVIVTHESDIAAQTKRIIHLQDGLITHY
>NC_019751|249445:282790|252929_253373_-|WP_015195980.1|DBSCAN-SWA
MQLTHFSKRLSTVGNFLAITVLCLSAIAFTWHSSLLSNTTAIAAPSVNFIANADSTVKGKANEDAGQTKNFIDDAADKVKNTAKRNASKVAESTDGNGSFVQRKALKDTATIQRRADEDAAKTKKAVDDTKNAVERTVDNIKDAFGK
>NC_019751|249445:282790|256348_257755_-|WP_015195985.1|DBSCAN-SWA
MRVYGYARVSTQEQAEEFDALNQQIARLKTAGATEILIDIESGRSDSRKQFNELLYLVQRNQVDEIIVTRVDRLGRSVITIHKAIEIFVKHEVNLRVLDAPVDPNSPFGWFSINQMSGLAEFESRLLSQRIKHGNNYFREQLKFCTPPFGYGKDENQRLVPNRNIHEKSGKTYFELGKLIIELILEMRSLKDVCTYIYVEYEIVFSVAGLRDWVKNLALQGHTAYFVKKKKGVNREPIINFDTHEALVSAATVEAIQQKLSANRRYRSSATSTRGDYPLSSLIKCAHCGGGMYRNFSRHKTKTEYMRCANYSKPGKYHCENSKCTRLREIIAQTITELCRHAPQLIDHLQSQSVTTVIVNTKEIENLSNELSVMRGLRSSNPDIIHAIAKIEETINSLSTPVKIVDRDAFENAQKQITIASQATFWESLDDLELRAALVEFVEKVEVNSSGSITPTFKLPLTRSSMRP
>NC_019751|249445:282790|272012_273026_-|WP_015195997.1|transposase|DBSCAN-SWA
MRFTKLNYCQYLLSSQINYTLTNLADHLEQISHDKINRYLKNEKLTPRILWDNVKDLIEINDNAYLVFDDTVIDKRYATEIEPSRRQYSGNEHGVIQGIGLVNCVYVNHEIGKFWVVDYRIYDPDRDGKTKIDHVMEMLQNLVYHKALPFKAVLMDTWYATNKLMLYIDGLGKYYYCPLKRNRLVDDTAGEEEYQRIELLSWDEEELKSGKIVKIKKFPQAKKVKLFRVTVSTDKTDFIATNDLSQDSTDVVQKVCKVRWKVEEFHRELKQLTGLESCQCRKGRIQRNHIACAILVWLRLKDLAYKSGQTIYKIKHGLLSNYLVQQLKRPNIPMFSF
>NC_019751|249445:282790|267215_267662_-|WP_015195993.1|DBSCAN-SWA
MQTKVISALVPTIIILGATPNISHAQFPSQPPGNMQMQGGIENIPDMNFTDDQKEKLQEVKTEMSDRMNQILTSEQQNYLKTAMNTGRNPQEVMKSLNLSRQQKQQMEGVQRWQRDQLFSILTNEQKQKLKETMMRKQGGGTPFGFRR
>NC_019751|249445:282790|268101_269334_+|WP_015195994.1|DBSCAN-SWA
MNIALKLKNNLKIEQHPLRLLLYLEWVLLGISIIIMNLPPARLVGETERANPILLIASITILGIMGLRLPKGNRFSKIIYIFLQLLLILLANIGVGDIVGFSPGLLLIVAIRSILIFKISESVIIIGLIWICFIFTLNTIKIPPKVPINPNEGFIWIVKLNVLMLFSLVLIFVLLLVNALFSELKSRQQLALAHERLREYALRIEDQATLQERNRIAREIHDALGHSLTAQSIQLENALVYLESNLEKAKSFLLEARKLSANLLQEVRCSVTTLRSDPLQGKSLDAAIQLLIVDFQSRMQISPNYSLRNNLSIPPELNRTIYRIVQEALTNISKHSEATKVKIDIQTTKDSFLVRVEDNGIGFDLKQNTTGFGLQSMRDRTNALGGQFYLNSEPEAGCSIMAIFPLSRLE
>NC_019751|249445:282790|277454_278849_+|WP_041740084.1|transposase|DBSCAN-SWA
MKKQGKNKQVSVGEKAQVFSQKGFELINPNAAGIDIGASEHWVSVPIGRDSESVRRFGCFTSDLQAMVTWLKQCGIKTVAMESTSVYWIPMFQILETSGFEVRLVNAHFVKTVPGRKSDVLDCQWLQQLHTYGLLSGSFRPEDQICVLRSYIRQRDNLIRSSSTHILRMQKALQEMNLHLNQVLSDITGITGLKIIRAIVGGERDPKVLASMKDCRVKSSITEIEKALTGDYRTEHIFVLKQELHLYEIYIAQIQLCDIEIEQYLGSFEDKNGDKPPLPPEKTKKTKGNSPQFDLRSHLYRISGVDFTAIDGFGVLTVQTLLSEVGLDPGRFPTVKHFTSWLGLCPGSRISGGKVLSSKTRKVVNRAATALRVAAQSLASSKSAAGAFYRRKKAQLGAPKAITATAHKLARIFYHMWKHGDTYVDTGANSYEHKYKQRAISNLKKKAKDLGFDLVEQPQIVEVS
>NC_019751|249445:282790|275122_276499_-|WP_015195999.1|DBSCAN-SWA
MTPPENKNLVEEHKELIKEVLEAYPEKSRKKREKHLNVMEEGKSDCGVKSNVKSVPGVMTARGCAYAGSKGVVWGPIKDMIHISHGPVGCGYWSWSGRRNYYVGTTGIDSFGTMNFTSDFQERDIVFGGDKKLVKIVHEIEELFPLHKGVSIQSECPIGLIGDDIEAVAKKTSKEIGKPVVPLRCEGFRGVSQSLGHHIANDAIRDWVFPLHDKAKKEGKISFEPSPYDVALIGDYNIGGDAWSSRLLLEEMGLRVVAQWSGDGTINELIQGPAAKLVLIHCYRSMNYICRTLEESYNMPWMEFNFFGPTRIAESLREIAAKFDDKIKANAEKVIAKYTPTMDAILKKFRPRLEGNTVMLYVGGLRPRHVVPAFEDLGIKVVGTGYEFGHNDDYKRTTEYVDNATIIYDDVTAYEFEEFVKHSKPDLVASGIKEKYVFQKMGLPFRQMHSWDYSEPGY
>NC_019751|249445:282790|255457_255970_-|WP_015195983.1|DBSCAN-SWA
MLKRSHLLLAVTGILCIFSYPDIPSVQAQTVTKSTLAAKPKLTFKQEFDRHTSFVDENCVRPEKRTFDGLKYELCRMEDIHTRVSIEGPEGDNGPTAYFYGGKLFAFRDTGSGQAWIFKNGKLIAEVEVGSVAPAYNMIKTTFTPKERKSQTDWAMKSTRSMLKVFGAKL
>NC_019751|249445:282790|262584_263172_-|WP_051036585.1|DBSCAN-SWA
MKFILVIIGFTLVLSLNNRSIQAQSLPSINIPSDVTPNSNEPLSSPTVMPSDAPSIEKEKPLRRYIGISGTIGVNGVGKGLSHGGITIFQKNDLSDSFSIRGSNIFGGDKNDSTFALTANFPVKTSSGQVKFVPFIGGGMLVRAKSNFEDINVRGLVTGGIDIPLSRSFTATTAVNVGLFQQTEVGVQLGIGYNF
>NC_019751|249445:282790|269333_269984_+|WP_041738909.1|DBSCAN-SWA
MIRLLLVDDQSIIRQGIKSLLESQPDFEVVGEAENGKQAISQVEILQPDVVLMDVRMPITDGVAATKAITQQFPLVKVLILTTFDDDEYISQGMRFGAKGYLLKDTPLEPLVNAIRSVHSGHTHFGPGLFERIMTPTVERTLAKTFTRPPELEQLTPREKEVLQLIASGASNREIAESLFIAERTVKNHVTNILTRLNLRDRTQAAIFANSFSFEQ
>NC_019751|249445:282790|278947_279913_-|WP_015196001.1|DBSCAN-SWA
MQTKQLGNSDLYITPIGFGAWAIGGSGWSHGWGSQDDTESINAIRRAIDLGINWIDTAAIYGLGHSEEVVAHALKGVSDRPYIFSKCSQVLNNKGEVSTVLKADSLRREVEESLQRLQTDVIDLYQIHWPNADIDEGWTTLTELQKQGKIRYIGVSNFNVEQMRRIQQIAPITSLQPPYSLLDRDVEQEILPFCQQEKIGIINYSPMASGMLTGAMTRERVKNLPDDDWRRRSPKFQEPNLSRNLNLVELLRQIGELYGRSPGEVAIAWTLRHPAVTGAIVGGRNAKQVEGIIGAGEFRLSDDEIKEIETFLSTLFYQVSV
>NC_019751|249445:282790|264144_265353_-|WP_144050985.1|DBSCAN-SWA
MSIESLWSNKLRTGLTMLGMIIGISSVIAITSIGEGVQKSTEKQIEGLGSDVLQVLAGESKSGNISKGLGSTTTLTWEDAKAIASEAPSAKVVSAYLQSKSQVVYEGQNTSTTVYGTDLNYPDARNTFPETGRYFNQEELDSSGQVAVIAPTVKKKLFGENINPIGSKIRIQGEVYEVIGVTEVKGSQGPMDRDDAVYIPLTTMSARIVGNNSLFGISVNGIYVKYGKKEEIKTAEFQITNLLRSRHDIQPPEIDDFRVTNQADILKTLTTVLSLLTLMVSAIAGISLVVGGIGIANIMLVSVVERTREIGIRKAIGATNSAILNQFLIEAIVISCVGGVIGIGGGIIIAFGAATAFNFPFVVSSNSIILAFGLSGAVGLISGVIPARNAASLDPITALRSD
>NC_019751|249445:282790|253502_254627_-|WP_015195981.1|protease|DBSCAN-SWA
MNNTIRVGNLFGIPFYIHPSWFLVLGLVTWTYGSGLSAAFPDLGNGFALLLGLMTALMLFASVVAHELGHSFVAIRQGIDVKSITLFIFGGLASLERESKTPAEAFWVAIAGPLVSLFLFGIFAGIGFGTGVSGALAGILGVLASVNLSLFAFNLIPGLPLDGGNILKAIVWKITGNPNKGVVFASRVGQAFGWIAIASGLIPLFLVGSFGNFWNLLIGFFLLQNAGNAAQVARVQEQLTGLTASDAVSNDSPIVSADLTLREFADEQIISGQNWQRFLVTNNDGQLVGAISFDNMRSIPTQLWTETQIKDVMQPIAESTTVQADKPLLEVVQLIEQQKLSALTVIRENGVLVGILEKPAIRLLLERRMQANPA
>NC_019751|249445:282790|249445_249910_-|WP_015195975.1|protease|DBSCAN-SWA
MLAIIGCGNLNRSDDGVGVLVAQRLQRYLIQHPHPDIRVYDCGTGGMEVMFQARGCTELIIIDASCSDSEPGAVFEVPGDELVELPEPGYSLHDFRWHHAIASGRKIFPHEFPLDVTVYLIEAGNIDFGWDLTSKVEQALNIVCEKIIERISNM
>NC_019751|249445:282790|250144_250606_+|WP_015195976.1|DBSCAN-SWA
MAKRSFPNSRRNTQVTLEPEVAIAVVGIFSSLADGDELGHEEDYALGEMLCSVSGFEDYSEEDYVNLYNRAIAVINEEGAEEAFTQAIGSLPNKNYREAAYVTAVTVVSIDGEFPEEEEDFLAGLQEALKISDTRAEEIIDEIFCEDEEEEEE
>NC_019751|249445:282790|281620_282790_-|WP_015196004.1|transposase|DBSCAN-SWA
MSNSTQLYSQVLGYLRQYSTYRDLRHLKTLAWMINGLICSGQLSLSAWEPYVDSYAKQAQSYERRWHRFLENIRINVEKIYLPLALLALKDWEKHRLYLALDTTMLWNRFCMIHISVVCCGRAIPLLWRVLEHNSATVAFKEYEVMLRKARWLLRRDSDIMILADRGFANHDFLSWLQKSNWHYCIRIPSDTCLHGVRRYPTHVKSIYPNRGQAAFYRNVGLWQDCLIRCNLVVAYPEVVSEHWAVVTDEEPALKTLHEYALRFCVEELFLDSKSGAFELEDSRIRDAESLERLYLIAALALLYSTTHGMAVQIAGLRTCVDPHWNRGLSYLKIGLRWLKGVIHKGRQLLTPIPLLSQDPQPSFASNKARQDDNLGICFSRIYSFNSWV
>NC_019751|249445:282790|250703_251363_-|WP_015195977.1|DBSCAN-SWA
MAIVWLIRHGESEANAGLVTAEVENIKLTQKGQQQAKKVALFFSEQPSLIVTSPYLRTKQTAEPTIERFPRIPQSEWEVQEFSYLATMRRKNTTLSQRVPMAEEYWQRCDPFYSDGEGAESFAKMIERCFGLQRQISQLENKFTAIFTHEIFMRVFIWLLLTNSREISPESMQKIKIFLDIFKVPNGGIVKLQIQNSDIWMNGVVTSHLLDLVSCGSSV
>NC_019751|249445:282790|280148_280712_-|WP_015196002.1|DBSCAN-SWA
MADLSNLRVAVLVSDGFEETELTEPVKALKEAGAKVEILSNKSGEIQAFRHQDKGTTVNVDRLIDQAQPSEYDAVLLPGGALNTDTLRMESKVQSFLKQMQQDNKPFAIICHAAWELVSANLVQGRTLTSYYTIQDDIRNAGGNWVDREVVVDQNWVTSRQPQDIPAFNQEMLKLFAKFAPTASNLR
>NC_019751|249445:282790|252267_252600_-|WP_015195979.1|DBSCAN-SWA
MTIIPNDSFPINITVKIRKSIYSAELYFDTKAHISYYHEVTEAEDCYIKLLLSEVTSKYYNKGKFFLLLDLRNVPKIGMVITPLDKLNELYTFTKNTENEILVTGNGNSN
>NC_019751|249445:282790|261144_262446_+|WP_015195988.1|integrase|DBSCAN-SWA
MQSQIHLKLIEVNQRLKSAKTKVTIRESNGSLQLRATLPIKPGDRDVNTTKRKQYNISLNIPANFEGLKTAEEEAYELGKLIARQNFEWNDKYLGNDSLKKDFSTIGELLERFEKEYFKTHQRTTKSEHTFFYYFSRTKRFTNSTDLATAESLINSIEQINQQWAKYNAARAISAFCSTFKIAIDLSKYSKMPESNSRKIPTDREIYAGIAKFEYYQNYRGKQVNQNVQDSWQLWRWTYGMLAVFGLRPRELFINPDIDWWLSSENVDLTWKVHKNCKTGERQALPLYKQWIEDFDLRNPRYLEMLATTINKKDQTKHAEITALTQRISWWFRKVELDFKPYDLRHAWAIRAHVLGIPIKAAADNLGHSVQVHTQTYQRWFSLDMRKLAINQALSKRDEVEVMRDENGKLKGENERLKLEVEKLKMEILYKHC
>NC_019751|249445:282790|251580_252003_-|WP_015195978.1|DBSCAN-SWA
MSELDLHPHLAKLPEDALKELAEWCMLDQAKEGGYEFTPDSIKLKKFTGGHYVEQLVDQFMNATRNTIEGGMAAFAAGKEADNHDLKGLPIVVDFISLYVKYLLPKGKKSTLSTDEKLAQASQQQFDKLNQIAAKYNVVL
>NC_019751|249445:282790|265454_266972_-|WP_015195992.1|DBSCAN-SWA
MKMDAQSSINDSTKISIGINKKNISNWSIKLLFFAFLIGVIFAGFRFLLMNPRQKSQTQLPTQPVERQNLNITVSANGKIEAERSINLSPKNAGIIKSLIVKEGDVVKKGQIIAYMDDSNLQGQLTQAKAGITSAEANLNKLIAGNRAEDISQSQAQLEEAQANLKKIIAGNRPQDIAQAEARLKRVKVTLNQAESDLKRYQELLNSGAISRQSFSTYQTNRDTALAQVQEAEQALKLQQTGSRSEDIEQAQAKVKQLQQSYNLIKNGARKEDIDQARSQVNSARGSLQTILAQINDTVIRAPFDGVVTKKYADPGSFVTPNNAGGASSSSVSSSILSLTANNQVVANISESNLAKIQIGQTLKIKNDAYPNKVFMGKVSQIAAQADVEQNVTSFEVKAAITSDNKNLLRSGMNVEVEFEVGQQENALVVPNVAVIRDQRGTGVYILDTENKSIFVPVKAGVAVNNKTEIKSGLKGGERVLLTLPPEAAKPQSGGFLPTPPKQES
>NC_019751|249445:282790|254845_255292_-|WP_158333117.1|DBSCAN-SWA
MLVLFSALTLGSIVCIQTQPAEARTVKCKLTTNCVYGSEISDRWIKGARFEQKADFQSAIIEYKKAFKASEKLTFPGKTQAQMKLLRACASTGSYASLQGAIAGAEYMKFHQLTAEHTKAAIEISRNKFREVSDAQDEKFPELAGSCP
>NC_019751|249445:282790|274406_274865_+|WP_015195998.1|DBSCAN-SWA
MTNNWIQVKGVIKPGYGVASGKGGDSRFPQGTIAMQKPFFQKLGLDLSPYFMGTINISIHPHQYTIINPKYTFRNLKWSSTEPAEDFSFLDCIIVLADAAPLNSLIYYPHPETKPEHFQTPDTLEMIAPFITNLKYGDVLLMELNSAQIAIV

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
248527:248543	attL	NA	NA	NA	NA
WP_015195975.1|249445_249910_-|protease	hydrogenase maturation protease	NA	NA	NA	NA
WP_015195976.1|250144_250606_+	tellurite resistance TerB family protein	NA	NA	NA	NA
WP_015195977.1|250703_251363_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_015195978.1|251580_252003_-	hypothetical protein	NA	NA	NA	NA
WP_015195979.1|252267_252600_-	hypothetical protein	NA	NA	NA	NA
WP_015195980.1|252929_253373_-	hypothetical protein	NA	NA	NA	NA
WP_015195981.1|253502_254627_-|protease	site-2 protease family protein	NA	NA	NA	NA
WP_158333117.1|254845_255292_-	hypothetical protein	NA	NA	NA	NA
WP_015195983.1|255457_255970_-	hypothetical protein	NA	NA	NA	NA
WP_015195985.1|256348_257755_-	recombinase family protein	A0A2H4J3Q1	uncultured_Caudovirales_phage	9.9e-12	22.2
WP_015195987.1|259072_260611_-	nitrogenase molybdenum-iron protein subunit beta	NA	NA	NA	NA
WP_015195988.1|261144_262446_+|integrase	site-specific integrase	C7F4E7	Cyanophage	1.5e-09	23.8
WP_051036585.1|262584_263172_-	hypothetical protein	NA	NA	NA	NA
WP_015195990.1|263299_263965_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.9e-36	41.6
WP_144050985.1|264144_265353_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_015195992.1|265454_266972_-	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_015195993.1|267215_267662_-	hypothetical protein	NA	NA	NA	NA
WP_015195994.1|268101_269334_+	sensor histidine kinase	NA	NA	NA	NA
WP_041738909.1|269333_269984_+	response regulator transcription factor	NA	NA	NA	NA
WP_015195996.1|270268_270415_+	hypothetical protein	NA	NA	NA	NA
WP_015195997.1|272012_273026_-|transposase	transposase	NA	NA	NA	NA
WP_015195998.1|274406_274865_+	hypothetical protein	NA	NA	NA	NA
WP_015195999.1|275122_276499_-	nitrogenase molybdenum-iron protein alpha chain	NA	NA	NA	NA
WP_041740084.1|277454_278849_+|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	1.6e-142	56.2
WP_015196001.1|278947_279913_-	aldo/keto reductase	NA	NA	NA	NA
WP_015196002.1|280148_280712_-	type 1 glutamine amidotransferase	A0A0N7KVR4	Yellowstone_lake_phycodnavirus	4.8e-18	35.4
WP_158333118.1|281057_281249_+	hypothetical protein	NA	NA	NA	NA
WP_015196004.1|281620_282790_-|transposase	transposase	NA	NA	NA	NA
296427:296443	attR	NA	NA	NA	NA

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_019751|291354:360224|DBSCAN-SWA
ACTAAGTCCAATTTAACAAGCATCTAATCTTGAAATTTTGAAAATTTCTGAATCCATATCCAGAGCGTTTTATCAGCTTAAGTTTATTATTAATTCCTTCTACTGTTCCACTTGTTGTTCCATTATCAAAATAAGCGATAATTTCATCAAACCAGCGAATAATAGTATTATTGCTACGAGGAAAGTATTTCTTTGCTTTTGACAACCACATTCCTAGCTTAAAAACTCCTGTGTACCAATGATCAGTCAGGTTAAATATTTTTCTAATTTTTTCTTTAAAATCATGCATTTCTTTCAAAACTGGAGATACTCTTTTAACTTCTCTGAGCTTTACTACTTGTTCGTCAGTTAAATTATCTTCATTCTTAAGTAAGGAATATTTACTATTTTTCAAGCCAGCTAAAATGATTTCATACTCAGCTTTTTCTGATTCTGACTTGGTTTCTTTGATTTGCTCTTCAATACTTCTTCTTTCCCTTTTTCTTTGCGTGTCTAGTTCTTTGTTTATTTGTGTCATAACGTGAAATCTATCTGCAACTACTTGGGCATTGGGCATTAATTCCATAACTAAGTTTTTATAACCTTGCCACAAATCAATACTGACCTCTTCTATTTGCTGTAAGACTTCTAATCCCCATCCAGAAAGAGCTTCTTTGATTTTATCTTGTGTTCTTCCATTCAAAATCGCAAGTAATTTAGATGCATCTAAGTCTACTAATACTGCACAGTAATCACCTTTGCCTTTGACTAAAGCAATTTCGTCAATTCCAAGCCTTTTTAAGTTTGATGGTTTGGAATCACATAATTCTTCCGATGCATCCTTTAACATTCGTTCTATCTCTTCAGTTGTGACAATGCCTTTTGATGCGACACTATGAATATCACTTTCTAAAACATCTTGTATTATTTTTTGTGCTAGTCGATTTGTGTAAGTCCTCTTCTTTTTTGCATAATACAATTCCTCACTAAATGGTTTTTGACACTGATAACACTTAAATTGTCGTCTATTTACTTCTAAGAATACTGGCTTCTCACTAAAAGGTAAGTCTTTAATAATATGGCTATGGTTTTGATGTAATTTTTCGCTTTTTGTCCCACAATGAGGGCAAATACTGTATGATTTTGTTGACTCAGTTTGTAAAATAATCCCAATTCCATTGTAAATGCGCTGTGAAGTGACTTTTATATCTTTTAAATCCAGAAGTTCTGTCAGAACTTTTATACTTCTTTTCTGAGTCATGGTTATCAGATATAGTAAAAATTATTTTTGTTGTTTTTATAGAAAACAACAAATAATGTCTACCTGTCAAGCTAGCAAAGCTTTAAAACTATATTTCAATGTAATTATTTAGAGATTTTTATGCTTTAGCTTAACCTTTTAGCATAACAAGTACCGAAGAACCATATTTTTTATTCGGGACTGTAAGTCTAATTTTCTAGATAGAACAAATGCCATTGGGTCTTCAGAAAGTTTCTGAGCTTTTTGACTAGGATTAAATCCTTCTTCTGGAAAATCTACTCCTTTTCCGAACCTTTGTGCATTTCCCGGTATTTGAGCTTCATCTACAATATCTACATTAATGATTCTCGAATTTTTACCTGGTTCTGCAACAGTCATCATTGATTTTGAGGGTGGTAAACCGTTTCCACCTCCGCTTCCTTCGCTCAGTTTTAACGATTTATTAGAGTTTGGTAGTTTGACGTAGATATCATTAGGTTGGGATGGTGAATATCTGAAAGGAAAAACATCACTTTTTGAAGCGATAAAAGATGGAATATCACCATTATGCTTGCTAAGATCAGAAGCTAACGAATAGCCTGTGTCAATATCTAGACTTTCAAAAGCTGTTTTAAAGCCATTTTTGGTTTTGGTAATATTCAGTTCGCCAAACTCAGCACTAATTCCTTTGGCATCTTCTAATCTTGTTGTCAGTTTTAGCCCATTGTTTGATGTTTGTGTAGGGACTGCTTTGAATTTAGAAAACTGGTTTAATTCTGCATCTAGATTGCGAATTTTTGTTCCTGCTTTGGGTTCAGTTATAATTGAACTAGTTTTTTGACCTAGAGGCTTAATTATGATATTAGTCTCTTCAGAAGTTTTAAGTGCTAATTCACCCTTTTGAGGTTTAACTTCTTGCTTGTAAGCAAGAGTTTTCTGAGGATTTATATTAGACCTTAAGGCAATATCGTCCAATGGATTATCCTTCGGTAAAGATATGCTATCTGCAAAATCCATTTTATTACCAAGAGAAACGCCTCCGTAAAGACTAGGATATGATTTACCATAACGCTCATCAATTTTTTCCGAGTCTAGAAACTTTAACTTATCCGTTTTTTTACCTCTATCATTGTAGCCTTCTGGAATAAATGTAATTTGACTCCATTTTTTAAATTTCAAATTTTTACCTTGCTTTTTAGCCCAATTTAGGAAGCTATCATTATCTCTATTAACCTCAATTGATTTTAAAAAGTCTAAAGGATCAGATTGCAAAAAGTTTTCTGACTTTTGACAACTTGTATCTTGAAAACAACTTAAAATATTAATTATTAAGTTCCACTTCATAATTTGATTAAGTCGCTCAAATTGTGGCTCATATCGAGCAACTTCTTCATAATGATTATTCCACCAATTAATAAAGGCAGTTGTATCGGGAGGTGCTGTAACCTCATTCTTTGATTTAGAATCGTTGGAAGCAAGTGCTTTAATATGTGTAGCATGACGAGAAAAAACTATATTCATGTCTACTTTGTTGCTGCTATAACCACTTTCATTTGGGTCAAACCAAAGCCGAACAAACTGTTCTTTTTGTCTATCTGATTTATAAATTGGCGAAGTGGGAATTTGAGTACTTGATCTAAAACCTTTAATACCTGTTTCTTCAGTTGCCTTCTCAAAATTAAAGTCAAAAATTTTCATTAACAAATCTGTGTAGAAAAGGGTCATGCCCACTTCTGTTCCTCTGATTAAGTCACCGTCATAGCGTGCAAATTGAAAGCCATTATTCTTTTTCGATGCTAACAAATTATTAATTTTGTATTCATAATTAAGCCGTGTATTTGTTTTTTGTTCTGCTTTCTCAGATGATTTTTTTAGGGTATTATCTTCTGCTAGTTTAGCTTCCAGTTCTTGGATAATAATGTCTAATTCAATAATCTTTGAATTGATTTCTTCAGGCGATAAAGCAGAATTTGATATGTTCTCCCTTTCAATTTTATATACTTCTATTTGCTTGTTAATAGATTCTTGATTTTTTTTCTCTTTTTCCTGATAACTTTTGATTTCCTTTTGAATTTCTGTTGCTATTTCTCCTTGTTTGAATATTTTATCTTTTTCTGATACCCACACACTTTCTATTTTGTCAACTAATTTAAAATAATCTTCTGCATCTTTACGTGATAAGCCATTTTTGGCTTTTTTAATATCCTGTTCATTAATCACAGCTTTCCCATCTATTTTTATTTTTTTCAGTAATGGTATTGCTTCGTCTAAAGCTTTTTCCAATCCTGGGTAGTTATACTCCCAATCTAAAGAAAAACCACTACCATCTACTATTCTGTTTTTGCGTGCTTCTTCACGCATTGGTTTTTTAGCATTTTCGAGTTCATCACCCGATAAGTTTTTTGTTTTTTTAGACCAATTTTTGTAAAAATCACTTTCGTAAAAATCATTTGATTTTTTATCTATGTCTTGACGTGCTTGGTATAGTGCAGCAATATCTTCTACTTTAAGGACTTGATATTTTGGGCTATCTTTGCCTCTATAAATTTTACGTCCACCCAAAACTAAGCCTGAATCAATAACTTGAGTAAAAGTTATATCATCTGTTTTACTTAGGAAGTCTTTGAGTTTGTCTTGATTAGTTATAGTTGTTTCGTAGTAACCATACTCATTACTAAATATTTTAGCTGTATCAATTTCCCCACGTCTAGTAATTTGGGCTAGTTGTTGATTAGCAGATATATCATATTCAAATACTTCAATTACCTTTGGTTTTATACCGATATCCTTACGGTGATAGTCTGCAATTTCTGCAAGGTCTTTCTTGCGTTCTTCTGATGATTGGTTTTTAGGAACAAGCGCAACTAATCTCCCATTACCAATGTGGCGAGAACGAGTAGCACCATACTCGAGTTTGGCATTAGCCATAGACCTCATAAAATCATATCGAATAATAGAAATATCATGGATACTTCTGCTAATTTCTTGAGTAGAAAGTCCTTTGCCGGAAAGAACTGTTAATAATAACCAGTCACGTAATTGTTCTTCTTTTTCTGTAGCTGAATTTTCAGGATTATTTAAATTTTGAGTTTCGGCTAATTTTTCATTTAACTCGAAAGTTACTTCTTGAGGCTGATTGAGAGGAAAATTTTTCTCAGTTGTGCTTTCTACTGGTCTAGCAATAGACGGAACACTAGTCTGAGCATACGCAACACCTAAAACAATGGGTGAGACTGCGATACTAATAATGCCTAATACGTCAATAATTTTTCTCATGACTTGCTCCTTCTATGTTTATATTTTCGGTAATTGTTTGTAGAGTTGATATTTTCTGTATTCTGTGATTACTGATTCTCTTGATTATCAGGAAAATCCTTCTGTAGTTGTTTGTGAAGTTGCAGATATTCTTCCTGTTCCAGTGTCAATTTTTCTCCAGATGATTGTTGAGGAAACCAACGCAATAAAGACTCTGTAAAAAGTTCCTTAATCTCTGTAGCTCGTTCATCTTTATTAAAAATAGAACCATTTTGAAAGAAACTTTTAGATGCTTTGAGCACCGCTTGATCATTTTGTACTTGACTTGCTGTTAAAATTTGTTGAAAAGCTGTCTTTCTAACTACAAATGTTGTTTTTTCTCGCATCATAACGAAGCCAGAAGCAAGAATTAAAATACCTGCTAATACTGCCTGAATTTTAATTCGTTTATCTTGGGAACTTAAAACCCAGGGAATAAAAGGTTCCATACTAAATTTCCCTTTTGTTGATACAGGTGTAAGTACCTGAGTTGCTTGCACATTCCCTGTAGAGGTAGCCACAAAAATATTATGTTCCCTCTCTTCCCCAAATAGGATATGTTTTAAATAATCACAAATCAATGCGGAATCTAAATCTGCTAAATCTGGCTTTGTCTCAACCAGTTTTTTCCAAGCTGGTTGTATTGCTTCTTTAGCTTGAGGTACTTCTTGTAGTAGGCTATGAACAGCTTCCTGTAATTGAAGTGCCGTATTTATTAAGTTACCAGTAGATTCAATTGCATTTTTCCCTCCCTTCTCCTCAGCAAATTTCAGCCATCCGTCACTTGGTTCTAGTAGTCCAATTTGATGCCAAAGATAAATTGCTTGTGCTGCAAAAAATGCATTTTCTGTTTCTTTCTTTTCCTCAGAATCAATATATGCATTTATTGGTATAAAGCCTTGTTTTGCTTCTGCTAATAGCTTTTCTCCTTTTTCATTGAGCTGAGAAGTATTATTGTTTGCAGATGATATTAATGTTCCTAATGGATTAATCAATAAACCCACAGTAAAAACAACTGCTGACTCAGCACTAAACGAGCGAGAATTATTTTCAACTGGAGCTAAAAGTTGATTCATTTGCTGTTGAAGCTGCTCCATTATATCGATTAGTTCATTGCGAGTAGCAACAGCTTGTTCAGAGTAAGGATTGTAAGTAATGGCTTTTTCTCCACAAACCAGCGCTTCAGCTAGTTGTTCGTTTCTCGCTAAATTCACTGCTCGCAAGCGGTAGAGGAAACTTAACATCTCAAAATTTTTCAAACTATAAGGATATTTCTTCAGATATTTCTCTAATTGATTTATACCCTTCTTTAAATATTTGATGTTACTTGCATGGTATATTTGTACATTTTCATTTGTCACATGTTCCAAAGCGGCTAAGTAGTGAATCTCTGCTAGTTCATCTTGAAAATCGATATTATGAGGTAAATATTTTAAGCGTTGCTGACAGTATTTAATCGCTAATTGCCATTTTTTTGCTTCTTTACAGGCATTAATTCGCGTCTGCCAAGCTTCTGCTAGGAGATTTTTGACTTCTTCTCCATCAATGACAGACAACTCCAATAGCTGCTGGATATAGTCAATGTGAACAAAAGCACGCTCATTCCAAGATGGCTTTGTTACATTCTGTATCAAACCATTATAAAAAGCGCAGTGAGTATCGATAAATAACTCGTGTAGTAAAAGCTGACGCAGTTTTACCGGGTTATTCATTATTATTGCTTCAGAATGACCACCAGCTACAGTTAACGCTAAATCTTGCCAGACTTCGCGTTCTGCAACTAAGTTCTTCAACTCTACTTGAACTTCACGCCAGAAAAAATCAGCCCGCTGCCATTTTGATTCCAATTCAGATGCGATCGCTTGTTGATGCTGACGCAACAAATGCCCAAAACGACCTAAAACATCAAGACGGGAACCAGAATATTTTTGCTCAATCAAATTCAGAAGCTTACAAGCTGCTTGCTGTTCAGTAGTTAAATCTGCGCGATCGCAACTCAAACTGTAGAGGTTTGCAGAGATGGAAGGGAATACTCGTTCTTGAGGACGACATAAAAGTGCAACCATGACAACTCCTAATGAATATTCTATGACTGGTATCGAGAAACCAAATAGTATTTAGTAAATGTTTTAGCGATTAGATGTTGAGATAAATCAATTGAGAATTACGAAAAGTTCATTTATTTTCTATCCAAAGAACTATTGTTTTACAAAAATATTATGTTATGCAAAATATTTATCCACACGTAGAATATATAATCTTTATAAAAGCTTCATGAATAAATATTAAATTTACATTCTTTGTCTTTCCTACTGCTAATTTACTTATCAGAGTATGATGATGAAATGCCTTTTGTTTATCTTGTTTTCCTCTCTGGATGATTACCCAACTTACAGTTCCCACTAGCATCAAAATAAAAATAAGAGAAATAGCCACCATCAATTGTGAATACTTGAATCCCCTGGAATCTGTGGACATATTATTTGCCGGGAGTGATTTTGAACTTTGATTTAATATTTGATGTTCGGGTAGCTGTAAATTAATATTTCTGGGTATTGTAGTTACAACCAGAATCTCATTAGTTACCCAATCATCTAAGATTGTTGATTGTTCCGTTTCATCTGGACAAGGTGCGATCGCACGCATTTGGATTTGTTGAATAAGACAATTACCTTCTCCAATATTATTAGAGCGAGAAGAACGTCTATTGAGGTTTTCAATATTATCTTGTGCTAGTAAATTAGCATCGAATTCACTCGTACTCACTATCAATTTCAGGATATCTTTATATTCTCTAACTCCACGTCGTTGAAAGTTAATTGGTATAGATATAGGAATATATTTCCCTTCTAAAACCCATGTCTCTTCTCCTGGTTCTAGCCAAATTCCAGTACAACCCCCAGCAAAAGGAATTGCTGTTATGGCAAAAAGCTCAGTTAAATTTAGTAAGACAGAGTAAAGTGTTATATCACTTGTATTAATTAATTTAACTTGTATTGCTGGAGGTTTTAATGTGTCGTCTTGAACTTTATATGTCAATGAAAGCTGATAATCCTGAACTTCATAAGTTTCTACATCTTGGAGATAAAACTTTACTTTTACCGCATTAGCTGGAATCAAACTATTTGCAGGACTTGTAATAGAAGCAATATTTCTCCATCGTGCAATATGTTCTAAAAAATAAATTGCTTGTAATGCACTCTCAATAGTAAAACCCGATATTGGAGATATTACCTGATAGTTATCGCTAGCACGAATAATCTGATATTCATCATTGATAGCTTTGAGGTAAAAATCAGCTTCGTAGGAATTATCAACTCCACAAATATACAGCGAAGCATTTTCCCCAAAACTAGCTGTTTGGATAGCTTGATGTGCAAAACTAACTCCTGACGTATCCCCTTCAATATAAACCTGGAGAAAAGCTACTGGAAGATAAGTAATTACAGCTTTATAAATTAACTCTCTGTTTAACTCTTCTCTTTCCCCAGATATATTAATTCTACTAGACTGCGGCAAAACTTCCGTGACTTCAGCCACTGCGATCGCATTTTCCAATTGGCTAATATCTTCTAAATCTATAGGGAAAATAGCTAATCTGGTATTTTGATTTCCCTGGGTAGAAATAATACCATGAATTGCACCGCCATCAATAATCCAAGCATTACTCCCATCATACATAACAGTAAAGTAAGTTAGTCTTTTAGCGATTGCTTTTCCTAAAAAAGGCTGGTCTAAATAGCTAGGATTTGTGGTTCTACCGATCCCCTTATGGAAATTTAACACTAAAGTGCCAAGATAATAAGCAGCGTAATCTAAAATTTGCGAAATTACGGAAACCATATCCTAATCTTTTGACTAGCTTCAACTTATTATTAATTCCTTCTACAGTGCCACTAGTTGTTCTTTGTTCAAAATAACCAACTATATCTCCAAACCATCTAAAAATTGTTCTAATAGTTTTCGGAAAGTATAAACTCGAATCATACATCCAATCTAATAATTTTAGTACCCCATCGCCCCATGATTCAGCAGTGTTAAATATATTTCTGAATTTCTCTTTTAACTCGTGCATTTTTGATAGAGTTGGAGATACATTTTGAACTGCTTTTAGCTTTTCTTTTTGAGTCTCATTTAAAGAATCTTCGTTTTTCAACAAGCTATATTTACTTTTTAATAATCCCGCCAATATTCGATCTCTATCTAATTTATTCTTGAGGGAATTTGCTTCTTTTTTTTGCTGTTTACGCGCTGCATCTAATTCATCATTTACCTGTTTCATTACATGAAATCTATCAATAGTTACTTCTGCATTTGGCATCAACTCTTTGACTAAACTTTTATATGGTTTCCACAAGTCTATACTAACTTCTTCAATTTGCTCTAAAACCTCATTGCCCATACTCTGCAAAGCTTGAGTCATTTCTGATTGACGACGTGACTCAACAATATCAATTGGTTTTCTTCTGTCTAAATCTACCAATACTCCTAAATAATTACCTTGACCTTTAATTAAAGAAATTTCATCTATACCTAGACGCTTTATTTCACTTGTCTCAAAACTGATATCTGATTCTAAAGAATCTAGCATCGATTGAATTTCTGATTCACTTAAATCATTTCTCTCTGCAACACTACGAATGTTACTGTCTAACACTTGTTTCACTATTTCTATTGCAAATCTTTTAGTATATCCTCGTTGTTTATCGACAAAATCTAAATCCTCACTAAATAATTTTTGACAATTTTTGCACCTAAATTGACGACGATCAATTCTTAATATTACTTGCTGATTACTCCATGGCAAGTCTTTAATATTACGCCAATGATGCTGATGTATACTATGACTAGCTTTACCACATCTTGGACATTTAGAAGATTTGGAGTCAACTTGTATTTCTATGATTAATCCTAAGCCTTCAATATCTTGACAATTTAATACTTTTATCCCTGGTAAATTCAGAATTTGCTCTACGGAAAACTTCATAGCGAGCACCGAAAATTTAATTTATGGCTATTTTACTTGTATTCTCTCACAGATTTGGTATATTTAAAAATCCATAAACCTTTATCTAGCTTGAGTTGTAGCTATACATTCTTGTTAAGTTATAGCCATTTTTTCACATCTAAATATATTTTTTTTCATAAGGGGATCGGTAGAACCGGATTTGTTGCTTCAACTTGTGGGGATTGATTTGTATAAATACTCCGTACTAAAATATTAGAACGTTTCAACAAATCTCTGTAAGTCAAATTACTATTTCTTTGTAGACTATCAAGTAAAAAGTAGGAGAAAATTCCTCTTTTTTGGCTTTGATGTTCCCTTGCTAACTCATTATCTCTACAAGCTGCTAGCAGTATATATTCTCCTCTAGATAAAGAAAATCGATTTGCGACATTACTAGAATTTGAGGTAGCAAGTAAACTATTGATTTCTTCATCTGAAAATATAAAGCTGGAAAGTGGTCTTTCTTTAGATTCTGTATTAACTGTACGTATACCTGTGTATGCGTTCAAAGATACATCATTTTCTGCTCGTGTCCCTCCACCAGAATGACAGCAATCCAAAATCACGACAAAATGGGGATGATTTTGAGAAACCTCTGCAATTAATTTGGCAAGCTCCTTATCAGCTAAATCCCAAATACCATCTGTACGACTATCCCAACACACCAAAGTTTCATTCAAATGGTCTGGTTCTAAATGCCAAAATTCCTCACTAGCATTTTCCTGAGAACCATGTCCACTAAAGTAAAATAATGCAACATCATTGCTTGTAGCTTGACACAAATGTTCCCGGAAACCATCGATAATTGCTTGACGAGTTGCTTGAACATCAATCAGTCTTTTGAGATGTAATTTATCCTCATTCGTTACTAAATGCTTTTTTAAAAATTCATCTAGTGCAGTAACATCATTTACACAACCTTTTAATGAAGGAATTTTAGAAGATTTGTAATTATTAATTCCAACAGCTAAAACATAAATATTGCGATCCATCACTGTACCCCTTGAGTTTTTGTCCAAAGTCCAAATCTAAACCAACTTCAGGTTTGCAGAATTATTATTGAATATGAATTATCACGCTCAATAACTAGATAATAAATTTTTCTAAGATACTATCTTCTCCAAGACTAATTTTTAAACCAAATTTATCCCCTACATTTCCTTTGAATCTAAGCTGTAACCAGTTATTTGCTTTTGATTGTTTTTTAAGTTGGGGAATTTGTTTATCTTCCTCATCTAACAATGTCATCTTGATTCCATCTAGTAAAAATATTGATTCACTAGCAGGGTAAAGTCTTAAGACAATCTCAACTTCATCTTGATTGACTTGTGTTTGACGCAATATTAGCAAAACTGGTTCTGAGGGATGTTGCAGATGTATAAATTTGGCAGCACCAGATTCTCTTTTTTCTGTTTCATCTACAGGAGAAATGGCTAAATCTTTTGCAACGGCTAATTCTGCTTCCCATCCACCATCTAATAAACCTTCAAACCATTTGCTCAATTTTACTATTCCTGTGTTCAGTTGACTTACAGCAACATCAACTATATCGACTTTATTAGTTGACTTTTCCATAACTGAAACAGCTTCTAATTTGTGTAGGTAAAGTAAAAAGTCATGTAGAGAGTTTAATTTCGTTAAAGATAATTTCTCATTTTCAACAGATTTAGCAAAACCTAATATCTTTGCTTGTCTATTATCTTCATCAATTTCTACCACCATATAACCAATACGTTCTGATAAAACTTCAGGTGGGATCTCACACAATTCTTCTTTGGGAAGTACAGGACGACACTCAATCAAACCCTTATCTTTAATAAACAAGCTAGCTGTATTCATTAAAGATGACATAATTTTATCTAAACCATGACTTTTGCTTGGTTCTGTTTTTATTCCTATGCACTTGCAGTAAAAGTCAACAGCTAATATAGCTAAAGTATTCAGATAAACTGTACGCGATTTTTGTTTGTTCTTTTCTTGCTGACTGAATTTTTCAGCAATTTTAAACATTTTCCCATCAATGGGTATCGTAAAAATCAACTCATTGGCATCCATTATTATTTCTCCTGATTCATTGTGTAATTTATTCATCTCAATAATTTTCAAATATTTTTCTTGTTAACTAAATCTCATAAGTATTTTTTAAAATAAGGACTAAATTCATCACAACAGCGACTATAAAATGAGTAAATAGGACCATGAGTCTTTCCTAAATTTAACTCTTGGGTAATTTCTTCCCAGGTTTTACATTCTTCATTCTTTTTGAGTAAAATAGCCTGAAAACTTGCTTGAGGATTCTTCTTAAATAGCTTACTAGCTAATAATCCTTCTGGATCTTCTTTAATAAATTCTATCAATTTCTCAGATGGAAGAGGATTTAAACTTGGAGGTTGATAACTTTCAAGAGGATTTCTTTCATATTCATCACCATCCTTATTTAATCCTTTATCTATATATGAAACTTTTCCATCCCAATTCAGCCAATTAAAAACATTATTTTTGCGTTTTTTTAATAAAAACTTTACCCAAGCCATTACAGAATAATCAGAGTTGTATTTACCTATGTTTTTACAAATATATAAGTAAATATTTTGCAGCGTTTCTTCATAAATATATTCTGATAAACCAACATTCCCTGGTTTTGGTAACTCCACCTTTATTCGCTCCATTAATAGGGTCATTAATTTTGTTAGCGCAATTTGTTTCTCTAACAATGCTTGTTGTCTATCTTCATCACTAAGCGACTCATTCTCAGCTTTTATGACTGCTTTTTGAGCTTTCACAGCTACCTCATCCAGAGAAGAAAAAGATTTCCCCATAGCAAAATACTCCTGCGTGCGTTCCTGTTATCCCTGTTTCCGTACATTTGACTGTTTTTGTAATCACCCTTCACAAAAATTTGCATATTCATAGGTTTTTAGCGATGTCTACGCCCGCCGCAGGCATTGCTAATCATGAGATAGTCGAAACTGAAGAAGGTTTTATCCTCCCCTTTCTCGCTCCTATATATCTCTCCCTAAGAAGAGTGAGTTTTTATGCATTTTCTGTAAAATGGTTTTTTCTTGAGAAATACCCCATTGGATAGATGCATAAATGCTAAATCAACAAAGTCAACATACGCACATAGGCTAATTCCGTATATATAACTACGTACCTCCTTATTCTTATATATATTATCTGTTTTGGCAACTATTTTACTCGGATATCCTTATATATCCTCTGAAATGGAGGTAAAATAGGGAATGAACAGCCAAATAATTTCTGGATAAATGTTGTCACGTAATTTTCTCTCTCAAATAGCTTACGAGCATGAACTGTCTCCAGAGCAGCAGCAAGTTTTTCTGATGCGAATTGGTGATGGTCTAAGTTACGAAGAAATTGCTGCTCAGTTGAATACATCCGCAGATGCTTGTTTGAAGCGGATGGGTCAGGTTTATAAAAAATTTAACATTAGCGGTGCGAGCCGGGGTAAGGAAAGTAAACTGAGATTTTTTCTGACAAACAGGTTAGAGAAGGTGACGGAGGAATCTTCAGCACATACCCAATCAATTGAGGAAAAGAAACAGGAAACTCAACCCAACTCGGTTGCTCAAAACTTACCAGTGAGGGAATATACAACTTTTGTTGGTCGTGATCAAGAAATAACACGATTGATGGAACTTCTCGATTTTCAGCACACCGCTCATTTAATTAGTGTGGATGGGATTGGTGGTGTTGGGAAAACAACCTTAGTAGTGGAAGTGGCTTATCGTTGTTTGCAAGCAAGCAATAACCAACTTCTGACTCCCAATCTTCCCACCTTTGAAGCCATCATCTTTACTTCCGCCAAACAGAATCATCTCACTTCCATCGGCATTTTGCCGCGATTAACTAAAGAACGGACACTGCGGGACATTTGCCGGGAAGTTGCTCGTATCCTAGACTTGAGTGAAATCACAAATTTACCCATCGAAGAGCAGTTTCAACCAATTCGAGAGAAATTGTCACAAACAAGAACTTTATTGATTGTTGATAATTTGGAAACCATTGAAAATCAACAGGAAGTTCTCTCCTTCCTCTATGACTTACCACCAAGTGTGAAAGTTATTATTACTACCCGCGAACAAGCATTATTTGTCCCCATTCGTCTTGGTTGCTTACCCAGAGAACATGGTTTATGTCTCATCCAACAGGAAGCGCAAGAAAAAAGTATAAATTTGACTGCTGAAGAATCTCAGCAACTTTTTGAGGGAGTCAGTGGAATTCCCGCAGCAATTATTTATGTTATTGGTCAAATAGCAGCAGGTTATTCACTGGAAGATGCTCTCTCACAAATTAAAGAACCCGATGGTGATGTTGCTCGTTTTTGCTTTGCTGGTTCAGTAATTCCCCTCAGAGGAACACCGCCCCATTATTTGCTGATGGCTCTTTCGTTGGGAGTTAAACCTATAACTAGAGAAACTGCTGCTAGTGTGGCTTTTGAGCAAGCTGACCCAATTTTAACATCCCAAGGATTAGCAAAATTGCAGCAGTTGTCATTGGTTTACCACCAACAAGGACGCTATAGCTTGCTGGAACTAACCCGCGAATATGCTGCTTCTGAGTTAGCTGCAAATCGTGAATTAGCCCAACAGTTGCAACAGAGATGGGTAAATTGGTATATCCGTTTTTCCGAGGTTTACGGAGGTACAAATTGGAAGGAGTGGCATCTTGGCTATAGTTACTTAGAAATCGAATGGGAAAACCTGAGATCTGTGCTTGAATGGTGTATGAGCCAAGGGATTTACGGAGATGCACGAACAATTTGGCAGCAGATTAAGGGTTATATTCATGTGCGTGGATATTGGGATGAACGCTTAGAGTGGACAGCTTGGTTAATTGAAACTGCGAAACAAGCAGGAGATTGGAAGTTTACAGTTGAGGTAATGTGCGATCGCGCTATAACTTTAATTAGGATGCGCCATGAAAACCAACTCACAGAAGCAGAGATATTACTACAGGAAGCTTGGAATTTACGTCAGCATCAAAGCATCGCATTACAGTTAGAGATAGCCACCAACATGGTTATCCTCTCCATTTATCAACAAAAATGGCAGCAAGCTGGAGAGTGGTTAACAGAGGAAGAAAAACTGTTAACCCAAACTTCTCTATCAGAACTAGAACGTCAGCAGCAGCAAGTTCATATTCTTTATTATCAGGGGCAGATATCCTTCAAAACAGGCAATTATCAGCAAGCACAAAGCTTTTTTCTGCAAGCATTAGAATCTGCAACAACAGCAGGATGGTTAAGAGCAACAACTGCAATTCAAAACTGGCTTGCAGATATAGCACTGGAACTAGGGAACCTCAAACAAGCACGACAATTGTTAGAAATTAGCTTCCCAATGGCAGAAAGACATAAAGATAAACTTTCTATTGCTTACCACAAAGCAACATTTGCCAAACTCGAAAAGCGTTCGGGTAATTTACCTCAAGCCAAGCGCTTGGCAAAGGAAGCAGCAGAAGGTTTTGAAAGTTTAAAGATGGTAGTGGAAGCAAAAGAAATGCGCTCTTTACTTTCTTGAAATAAATCAATGGAGTCAAATTATGATTTGGGGATAGTTAAGCAGGCACTTCTCTGTAATTGAGGGAAATGCTGGGGCAATATCAAACAACGTCCCTGGTGATATGCTACATTGTGGCAGATATCTATGCCAAAAATCTCTAAAAACAAATGTTTAGTTAAATCAAAAGCTGTTTTCTGGAATTTATGACTAATTTCTAAGTCATCATCAGCAGGAGAATAATGATGCAAAATATAACCATATAATTCTTGACAATCTTCAATATATTTAGCCGTGTTTAGCAGAATATGAGTATGCCATACTCGGTCAATTTCTACTGTAGGAACTAATTCGGTATTTGGAAATAGAAAATGAAGGCATAGAAACATTTTGTATAGATGAATTGCAGACTTTGTTTCTTCTTCTGTCCATTGAAAGTTCTCAGTATTGGAGGTAAGCTTTTTTGAGATTGCTCGGAAATCTAATTGATTTAATTTACGGAAAAAGTTTGTAATTTTTTCTGCAAATTCTTCATTGGTTTTACTCGGTAATTGTTTCTCCCAAATTGTATTCAAGCCGTTTTCTCCTCGTATGGATTATGAGATTGATTGTGGGAGAAGTGACAAATATTTCAGCATCCCCATACTATCTCTCCAAATTTGAGGTCATGATTTATGCATTTTGAGATTAAAAAACTAAGTTTATCCCATGAAAGCCTAGTACCTGAAGGCAGCGGTGAGTAGGCAGTGGGGAAAGTCTATTATTACTGAGCTTTTCAGGATTAAATAATGGTATTCTTCTCTTACAAAGTTTGGCGAAGAATACCCCCGCAACACAGTGGCTCAACTTTGCGCTATTTACGCAGTCTGGTACTAGATACTTAATACCTGCTCTAATTATTAAAATAGCAAATTTTTCGACGATATTATGGAGGTATTTTACCGGAAAAACTCCATAATATTGAGTCTCAAATCAACAAAATTAACATCCCATTATTCACAAATTACGCAACTTATTCGGAGAGAAACTTAGAGTTGATTCGCAAAGATATTCCATTTTCGATAACATCGAATTTTAAGGGTTGAGAATTAACTTTCAATCGTTCATTCCCATCTGCCCATAGAGTCCGCCAAGGATATTTATTCATCACCTGATTCAAAGCATCAATTCTTTGCTCTGTGGTTGGGTGGGTACTATTTTCTGTGTAGTCAGAAGGTAAACGATGGAATAAATTAAATACTCGTAAACCTCCATTTGGATCATAACCAGCTTTACCCATGTAGGTGTAACCAACAGCATCTGCTTGAAATTCATGCTGGCGACTTAATGCCTGTATCGCCTGATCAAACTCTTGTTTTTTCTGAATAAGAATTCGCTGTTTAATTACGTCTTTTTCTGCTATTGATATTGGTTTTTGGGATTTTTGTTTTTCTGCTACAATCCAGCTAGTAAACTCTGCTTCTGCTTCCTTTAATAATTTATCTTTTAAACGTGCTTCTGCTTCTTCTTGCTGGGCAGAATGGCGTTGTGTATGGTGAGCTAATTCATGAGCAATGATAAAAGCTAATGCGGCATCATCGCCGTGTATTTGGTCTAGTAAACCTTTGTAAATGACAATTTTATTTAATTCACCAGCATATGCATTGATATTATACTCATCGCTGACCTGAAAGCGCCAAGGATGTTCATCAAGTCCATTGGCACGAATCACTTTTTCGGCAACACTATAAACCCATTGTAAGTTAGTTTTTTTCGGCTTTACCTGTGAGGTAGATATTGATGAGTTTGTGATTGATAAATCTGGTAATGTAATTAGTGCTTGGGCAAAACCTGGTGTATTTAGGCTTAGTAAGATGCTGCTGCTAAAACCTAATGTGGTGAAGATAATTTTGCGAATTGACTTAATGTGTGAGGTTTTCATAATCGTAAATAGTGTGGTGATTATTTGAGCGTTCTTAATAATATTTACGGGACGACAATGGTGTTTTTACGCATTTTTGATTTTTTACTGGAATTTTTTTTAATAAAAAAGCGGGCATATTGCCCGCGATACAAAGTTAAATAAAAGAATGGAAATTTTATGCGGATAATTGATTCCGCTATTTCTAAAATTTCAATGCATTCAACAAATTTACTAGCATTCCCAAGTGTAAGATTTTCAGCGCACACGTTCTGGATAAACTCCAAAAGAATCAAAAAAATTAACAGCTTCTGTGGTTAATTCTCCTTGTGTTGCAGCTCCCATAACATACATCCGTCCCTTGACTATAAAACCTCGATATTGTCCCGTTGTTCCGTCAGTGTGTTGCACCAACAACTCTAAACCTGGATATCCATCAATTTCCAAATTAGTGCTTCTTACGATTTTGCCTGTACTAGCCATTTCTTCTCGCATGGAAGTCTGCAATACCTGCTCAACTTCTTCTACAGATAAGTAGGATACGTCAACTGGCATATCTTTGTGAATAATCACGTATACAGTTTGGGTTGTGTCGCTCCACGACATCAATTTCCTTTCTTCATTTTCTTGTACTGAACCTGGCATTTGAATTTCAAAATCCTGATTTGGTCCCCGATAGGTATCATTGATTGCAATTAGGCTAGGTTCTTTTATTACTTGGCTGTTATTAGCCAATACTGAAAAAGTTTGTTTGACTTGATTTGCTTGGGTGTTTGATAAATTTTTGGCTTCTGCTTTAGGAATGCAGACTGAAGCGACTAAGACTACTGTCGCAACTGACAACTTCCATGATTTCATTGCAGGTTTCTCCTATGATTAAGTTATGGGGAAGTATTGTTTTGAGGTGAGTTCTATTGTTTGAACCCCTTCATAGGGATATACAAATTTATTTAGGTGCATTTACGCAGTTTGTGAAAGTTTTTTTAATTTTGTTAAAGAGTAATGTGATGCAATAAGGCAAATTTATTGACAAATATTTTAGGGGTATAGCGTTTCCGTATTGGATTATGGCTGTTTGATCTTTGATGCGATCGCATGTGTGAATATGTGAGATTACCCCTATGCTTGGATTGGGGTATTGGTAATTAGCCAAACTTGTTACAATCCCTGACAAATCCATGCACCCCAGTAAAATGGATGTTCCAAGGGTTTTTTATTGCCATTAGTTGAGATTTCCAACCCTCGTACTTGTGACAATTCTGTTAAAATTTCCATTCCCAAATCAGATTTTCTTAATTCTTCTACCGTAATATTACGGATGTAATTTTGAGCATTTTGTAATGCCTCAACAGCAGCTACACCATTTTGATAATGCTCGAAAAACTGCTCCATCAACAATGCAGTTGCTCTACCTGGCACTTCCCACAAACTCATAACTAATATTTTGGTTCCCGAAGAAGCAAATGCACGACGCAATCCAAATACACCCTCACCAATTTTAATATCACCCCTAGCTGTATCACAGGCAGATAAGACGGTGAGTTCGTTTGCCCGCAAATCTAAGCCTGCGATATCTTGAGCAAAAATAAAGCCGTTTCCTGCTTGTTTTGGTAGGTTTCCACCTAGAAGTGCTGTGTTTGCACCTGCAAATGCAACAGCAGAACGCATCATTGGATTACTTTGTCGGGAGTCGGGTATAAATAAACCGTGGGTAGCAATCAACATGATGCTGGGACATTTGCTATTGGTTAAGCAGGTTGAAAGCGCTTTTGCTCCCGTATATAACCGAGCATTTTTTAGCTTTTTAGCTACACTTGCACCAAGCAATCTTGTACCGTGAGCAGGGGGTAGAACTTTAATATCAAGTTTAATATCAAGGGTATCGAGTAATTCTTGTTTTGTTGGGTTTTCCAAGTTTGGTAAATTATTGTTTGCCATTGCTAAGTCAAAGTCTGGATCGGCGATGATGATGGGTGTATCCCCAATTGTTGTTGGTTGATGTTGAGAATGGATAATATCTCGTCCAACTCCCAAATATGACACCGTGTATTTGTCCATGAGGAAAGAGCGCTCGCTTGGATAAATTGGTAATATTTGTAACGGCACTAAATTCAAATTCCCATCTGGTGCAAATATGATTTGGTCACAATCTGTTAATACATCAAGGATTGGCGATAAAATTATTTGACTGAGTTCAACTGCTGCGGCTGGATTATATTGTTTGATTTGCAACTGCGGTGTAGTCTTTACCTTTGCCCATCCTAATGTTTCTTCACCACCATCGGATGCTTCCAAGCGGAATAAGTTAATTAAATTATGAATAGTGTCTGCTTCCCCTAAATCTACCATCTGTACTCCATCTGCTTGTCCAGCAGGCAAAATAAAAGCTAGATAATGAGGAGATTTCCATTGGGTTTCCCCATTTGCCTGAATAGCTTGGAAATCAAAGACATCAAAAAGGACAAATTCAATTAAAACTGATTTAGTTGGTAATGCAGATGCGACTGCGTGACGGTTGGGAATTTGTGTAGATAATTGGATTTCTGGTACTTGGGATGCGATTTGTTTTTGGAGGTTATCGTATTGCGATCGCAGTTGAGTCAGGTTACTTTGATAATTGGCAATATTCTGAGTTTGATTGGCAAAAGATGTTAAGCGTACTAGTTGGGTATTCAATTCGCTGAGTTGGCGAAATTTTCCTGTAAGCTGAGGATAGCGATCATTATAAAAAGCCTGACTTTGAGCAGCAAGGGATGCAGCAGTTAAACCTTTGCGTTTGAGGATGAAATCAAATGCTTCTTGGGTTGCTGTTTCAGAATTTGGGAAGTATTGATAGATGAGGGATAGGAATAAATCGAAATTGCCTCTAATTTTATCAATAAAGGCTAAACGGTCGTTTTCAGAACTAAAGGCAAAAACGTTACTAATTAGTTTATCGTGGATTGTGCTGGCTTGGATACGATGGGATAAAGCGTTATCAGGACGTTTGGTTGCAGCGTATAAGGTTGCTAAGTTATTTAAACTTAATGCCACATCGGGATGATTTTCTCCCAGAAATTTGATTCTCACAGATAAAGCAGAGGAGTAATATTTTTCTGCTTCTGCATACTTGCCTTGAGCTAAATAAATTTCTGCTAAATTGTTCAAGGTATTGGCAATATCAGGGTGTTCTGATCCGAAGATACTTTTTCTAATCTCTAATACCTGTAAATGGATTTCCTCTGCTTCCAAGTAGCGTCTCATACTACCATATATAGCCGCGAGATTATTCAAAACACTGGCTACTTGTGGATGATTGTCTCCAAATTTGGTTCTAACAATTAATAAGGCTTCTGTGAATAAAGGTTCTGCTTGGGAATATTTAAATTGAGCATCGTACAACACCCCTAAATTACTTAAAATTGCAGCGACATCGGGATGTATTTCTCCCAAGAGCTTTTTATTCAACTTATATGCTTCGAGATATAAACCTTCAGCTTGAGAATATCGTCCTTGCAAGCGATATATTTCAGCAATTTTATTGTAACTATCAGCAATATCTGGGTGTTCTTCTCCAAATATGTTTTTTCTAATTGCTAAAGCTGCTAAATATTTCTGTTCTGCATCGGAGAAAAGTCCTTGTTCTTGATAAAGACTTCCTAAATGGTTTAAATTATCTGCAACAATAGGATGATTTTTACCTAGTGATTGTTCATGTAAAGATAATGCTTCTAAATATTTTGCCTCTGCTTGTTGATAGCGTCCTTGATATGTGTAGAGAACTCCAAGATTATGCAAACTTAGAGCAATATCTGGATGTTCGGGGTTTAATAAATCTTTCTTGATTGAATCAGCTTGAAGATATACTTCTTCAGCATCTAAATAACGTCCTTGAATTAGATAAATATCTCCCAAATTACTTAAACTTTGGGCAACCTCTAAATGCTCATCTCCAAATATATTTTTTCGCATTGATAAAGCTTGGAAGTGAGTTTTTTCTGCCTCTGCATAATGTCCTTGATTTTTGTAAGTATTTGCCAGATTATTTAAGGTAATTGCTATATATGGATGTTCTTCATTTCCCAGACAATTTTTACATAATTCTAATGCTTGAGAGTAATTTTCTGCTGCTTCGACAAAACGTCCTTGGGAATTATACAAAGCTGCTAAGTTATTCAAACTTGCGGCAATCTGCCAATTTTCATCACCAAATATCTCCCGACGAATTTCTAATGCTTCTAAATGAGTTGTTTCAGCTTCCGAATATCGAGCTTGATTTTCGTAAATCACTGCCAAATTATCCAAACTTTGAGCAATATCAGCATGAAAATCTCCAAATAATCTCTTTCGCATATTTAGCGCTTGGAGATGGATTTTTTCGGATTCTTGAAAACGTCCTTGTTCCCGGTAAACTTCGGCGATGTTATTCAAATTAGTGGCAATTTCTGGATGTTCATCACCTAGATATATCTTCCAAATATCCAAAGCTGCAAGAAAATAGTTTTCTGCTTCTATGAAGAGTCCTTGAGATACATAAAATGCAGCAAGGTTATTTAAAGATTGGGCAACATCAGGATGGGAATCTCCTAACAATCTTTTGCGTAAGTTTAATATTTTGATATATAGGGGTTTTGCTTCCACAAAATAACCTTGCATTCGATACAATTCTGCGAGGTTATTCAGACTATCAGCAAAAGCTGGGTGTTCATCAATATTTTTTTCTCCTAGTTTTACAGCTTCTTTTGCAATGGATATTGATGCTTCAAAATCTCCGGCTTCAGCTAATTTAACTACTTCTCGATTTAGCTGAGTGATTGTTTCTATAATTTCTGATATATCTTTCATAAACAAGTAAAAAAATAAAAGTTAAAAGGCAAAAGAAAAAAGAATAAGAATTTTTCAGAATTTCAGATATTTTCAATATTAGGTTTATTTACATTACGTTCTCTGAAGTTGATACAGTAAATTTTCCGTAAATGAGGTACATCGCAGAAAACCTATAACCATGTAGAGACGAGACATGTCGCGTCTCTCTTTATATTTCATTAAAATGTAAGTTACTGAAAAATAAGGTTTTTTCATGTCATTGCAACGTAAATCTGTAGTATTTGGGTAAGTCCTGTTTCTTTCTCTTTCTTGTTCTTTTTATTTTTCTTCTTCTTTTACCTTTTTACTTTTGCCTTTTTACTTTAAAATTTGATATTCAGTATATAAAATCTGATTACCGTCATTTTTATTCACATAGCTTATTAACTCCATCAGATGACTTTCAGTAAGTTCTAATACTTCATCACTATCTTGAAGTAACCATTGTAAATTAGGGATACTTGGAGAAATGATTGCTAATATCTGTTCCTTACCTGGTTTTCCTTCAACGGGAAATGCTGTCATGGGTGAACCCATTTGGGGAAGACTGGTTTTTCCATTTTCTAATTGTGGTTGAGGTGCAAAAGGGGATGGACAAAAACACCAAATTTGTCCACATGTATCTTTTTGAATTAGCAGTAAATATCCAGGTGTTTGCAGATTTATTTCAAACTGAATATAGTTGCCCAAACGTACCGATTTTTCGTAATAACTACCTATTTTCTTTCCCCAACCTAATGTTTCTTCCTTGACTAATACCAATCCCATTTGTTCTGTAGGGGAACCCAGTGCTGTTAGTTGCTGCCAAATCTTCTCTAGAGGTGTTTGCTGTACCACTTCTTCTTTTTCTGCAAACGGTGCGACAATATCATGCCATTCTAGATCGAGAAATGTACATATTTCTTCAAAATTGATGCGATCAATCGGTTTTTGATTGAAAAAGTTGTTTACAGTTGCCCAGCTAAGTCCCACTTCTACTGTCAGTGCTTTTTGCGTCAGACTTTTACGTTCTAAAGCTTGTTTTGCAAGTTTGATACCAGCACCCGATGCTACCAGAGAGCGTTTAGACATAATTCAAAACAGTAAATAGCTCTTTCTAAGTCATATACGAAGTCATACACCTAAGTCAATAACTCAGATATGTACTCATATAGCTGGTTGCAAAAATTGAATCAGGGGCAAATTCAAGCTTTTAACTTTTATAACCTATGTTCACTTTAGAACATCTCAATTATGCATGGCTACAAGTTCGTGCGGGAAGTAAATCTGCGGGTGTTGATGGTATTTCTATTGGCTTTTTTGAGTCAATGGCTACCGAACAATTACGCAATTTGGTGTCGCAACTTCAGTATGGAACCTACACTGCAAGTCCAGCAAAGGGGTTTTATGTACCTAAAAAAAATGGTGGTAAACGATTAATTGGTATACCTACTGTTCGAGATAGAATCATCCAGCGTTTATTACTCGATGAGTTGTATTTTCCCTTAGAAGATACCTTTGTCGATTGTAGTTATGCTTACCGTCCTGGACGGAATATTCAACAAGCTGTACAGCATTTGTATAGGTACTACCAATATCAACCTAAATGGATTATTAAGGCTGATATTGTCGAGTTTTTTGACAATATCTGTTTAGCTTTGTTATTGAATGCCTTGGAGAAATTACGACTTGAACCTAATATATTGCAGTTAATCGAGCAGCAAATTAAGTCGGGAATTATCATCAATGGACAATATCAAAATGCAGGGAAGGGATTATTACAAGGTGGTACTCTTTCGGGTGCTTTGGCTAATTTATACTTAACTGATTTTGACCAAAAATGTCTGAATCAGGGAATTAATTTGGTGAGGTATGGTGATGATTTTGTCATTGCTTGTAGTAATTTTGCAGAAGCTAATCGGGTTCTCGACAAAATTACTGGATGGTTAGGGGGGGTTTATTTAACTCTAAAAGCCGAGAAAACAGAGATTTTTAGTCCTGATGATGAGTTTACTTTTTTGGGTTATCGATTTGCAAAGGGTGAGGTTTTTGCACCACCTCCACCGGAACCAACGCAGCAAGGGGAATGGGTAATTAATGATTCAGGGACACCTTATTTTCGCCGCAAACCAAAACCAGAAAAGCCCGTTTCTCGTCCCCCTAAAGCTTGCAGCATCGATAAACCTGTTAATTTTCCACGAGCAGCAATTTCACATTACTGGCAGGATTTTATGAGTACATTATACGTTACCGACCAAGGTGCTTATTTGAGTATGAAAAATCAGCAATTTCAGGTGTTTTATCAAGGAGAATTGAAGATAAAAATACCAGTGGTGCGGGTCAGTAGTATCGTTATGTTTGGTTGTTGTAATGTTTCTCACGGTGCGGTAAGCATGGCTTTAATCCGACGGATTCCCATAATGTATTTATCTCAGAAGGGGAGATATTTTGGACATACCGCAGTCCAGGGTAATGCGAAGGTTGAATATTTGATGAAACAAGTTATTTGTTGTCAAAATCCTGTATTTACTCGTCAACAAGCAGAAACAATTGTTGCTGCAAAACTACATAATTCTCGAATTTTATTAATGCGCTTAAATCGTCGTCGAGAAACAGAAATTGCAACCCAAGCGATAGATTTTATTGAGATTTTGATTGATAGTTTACCGAAAGCCGAAAGTATGGACGCATTGCGGGGATATGAAGGAAAAGCAGCAACGATATATTTTCAAGCTTTGGGTTCTTTGTTTACTGGCTTTTTTGCTTTTGATAAGCGTACAAAGCGTCCACCGACTGACCCAATTAATAGTTTGATGAGTTTGGGTTATACTTTACTAAGTCAGCAAGTATTTTCCTTTGTGCAGTCGGTGGGGTTGCATACCCATTTTGGGAATTTACATGTTCCCCGCGATAACCATCCGGCTTTAGTATCAGATTTAATGGAGGAATTTCGCGCTCAAATTGTTGATTCTTTTGTGAGTTACATTGTGAATAAAAAAATATTAACTCCTGAAGATTTTACTTCTCCTGATGAACGGGGAGGTGTATATTTGCAAGCAAGTGCGTTGAAGAAGTATCTGAAGCATTGGGAGGAGAAGTTACAGTCTGAGACTACGCATCCAAATACTGGTTATAAGGTAGCTTATCGTCGTTGTATTGAGTTACAAGTGCGCGAATATGTTGCTTGTTTGGTAGGTGAGGTTGAAGTTTATCGTCCGATGACTTGGAAAATGTAGTCTATGATACTGTTTGTGGGATAGAGACAATGGCTGAAACCCTCATTCTCTCGTTCTATCCCACAAATCGCTATCCAGGTAAGGGTTTGATGCTTCTTGAATATGGATTAATTACTAAGAATTATCAATTATTTAGGAAAAATTTTACACCCCACAAAAAATGGCGGTAGAGTAGTTGCTAGGCAAGGCTTTCAAAGGCTAGCCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACGAAACTGCTTCTGCTGATTGAGTTAAAAAGGATTTTCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACCTCTGTACCTCTCCCCTGTATCGTTGCGCATAGATTGCGACTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACTAGATATTTTCTCTATTTCACGACCATCTTTTTTAATCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACTTGAAGTTTCCGTCTGTTACAAAATCATCTAAATTGCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACGAGGATAAATTTAAAAAGAATGAAGTCGATACGATCACTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACGAAATGGATAATTTTTGACCGAATACCACTTTTCTCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACTATATGATTCGCTGCTAAAGTATTTTTCAACCTTCTTCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACTTTTTACTCTTTCAAAATAAGAGTCAAAATTTTTTCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACAGTAGCACAATCCCATTCAGTAATTGCACATACTTTTCCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACATTGTTTGCCACATATTCTGAAAATAAAACACGAGTTCTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACACATTTAACAAATTATTTTGTCAAATCTGAAAAATCACTTTAAACTTCTTCGGAAGTTGAATTAATGGAAACATAGATTAAGATCCTCGATGTTAAAAAGTCGAGGATATTTTCGTTTGCCAGATATTTGGGTTTGAAAAATATCGTAAATATGAGAATCCTACTAATGATTAATTAAAAGTCAGATAACTCATATACAAACTCATATAAAAATAGCCTTTACTCCGATACATACTCATATAGACTTTTGGGAAGATGGAGATAAGTAAAAGATAAAAAGCTAAAAGGACATTCGGCAAAGCTCAGTCGAGCCACAAAAGAAAAAGTCTTCATACTTTTATTTTTTACCTCACACTTTTACTTCACCAAACCTATGTCTACAATTTATATCACCGAACCAGATGCATCCTTCAAACTACAAAATAAGTATCTGAAGTTACTCCAACAAGATAAACAACGCTTTTTCATCCGCATTAGTAACATTAGCCAATTCGCCATTTTTGGTAACATCAAACTACCAAAAGATGTCATGCAAATAGTTCGTTTAAATCAAATCCCCGCCATCTACTTCACTCACACAGGTGAATATGTAGGACGCTTAGAAAACCCGTCTACAGTCCAAGCTAAATACTTAAACTACCAACGTCAACGCTTACATGACAGAGAATTTAATCGTGCAACAGCAGAAAGTATAGTTTGGGCAAAACTCCATAACCAACAGACTTTTCTCCAAAACTGGACTCGTTACTGCACAGACTACACAACTCAACGAGCTTCGGATTATCTAACACTGCTGATGGATAATTTATCCCTCGCACCATGCGTTGAAGAGCTGCACCAATATATTGAGGAAGCAGATAAAGTTTACTACTGTGCTGTTGCTTCTATACTGAGTTTATATAGCTCAAACCCACACACAACAGCGAAGCAAATTAACAGGTTTTTAAATCTGGGAAATCAACTGCTACACCAATATATTTACAACCATCTAAAAACAGCAGGACTTCACCCAGACTATAGCATTTTACACCGGGACACTCATCACGAACTTCCTTTGGCATGGGACTTTAGTGCAGAATTTCGCGCACCGATAGTTGATGATTTGGTGTTAAATTTTGTTCGTAATCTTGCTAAGAATAATGGTAATGGTAACGGGAATGGGAAAAAACCTTACACCCATCTGCAACGTTTTTTACAACATTGGGAAGGAAAATTAAAAACCTTTGTACTACATCCATCCGCTGGAGAAGTTTCTTATCGTCAGTGTATTGACTTACAGGTCAAAGAATATATTGCATCTCTGTTGGGAGATGTCGAATATTACCGTCCTCTTGCATTGAAATTTCACCCAGAACAAACCAATTTCATCAATATGCTTGAAACCCAAAAACCAATATTAACCTTGGTGAAATAGGTGGAATAGCTATGTTTTATTTGGTTTGTTACGACATTGTGAGCGATACCCGTCGCAATAAAGTTTCCAAACTGCTGGAAAGTTATGGTTTACGAGTACAAAAATCTGTTTTTGAGTGTGTTTTGGATGAGAAACAGTATGAAAGTATTTCTAAACTCCTGATGCGACTACTTAACCGACGGGAAGACCAAGTGAGATTTTATCCTATGTCTGCACACAATCGTTGTAAAGTGGCAGTAGTGGGAACACAACCCGAATTTAGTGTCGATGATGCAGCTTTTATAGTTTAACAAGTTTAGCTGCGGCAATTCAGACTGCGAACGGCTTAAATATAGAACCCCTCTCCAAACCTCTCCCCGTAAACGGGGAGAGGCTTAAAACCCAGGTTTTAACATTAAAAAAGTCGTTTTTAGTATAGACAAGATTTACCACAATCATAATAAACAAGATGAAGCTTTACAAGCAAGCACGCGCTCCACCTTTGAGTAATGTGCTTCGGTCAACTGTGTATATTTGCCTTGTTGTATTGGGAAATGATTGAATGCAAATTCAATGTGTCAGGTTTTGTTTAATTTTTAGTCCAAAAGCTGAAAAACAACTTGATGATTTACCAAATAAAGACCGCAAGCAATATGACAAAGCTTTCAAATGTTTCATTCAGAATAGTCCTGCTTATCGTAGTTTAAGAACTCATCGCTATTGTAGTAAAGATGGTGATATTTGGAGTTCTTCTGCGTCGATGGCAAAGCGATTTTATTGGCGATATTTGGAGGGAGACATTATTGAGATTACTCATATAGATTCGCATTGAGTAAGTAAAAAGGTAAAAGAGAATAATTCAATCTTTCTTTTACCTTTTAGCTTTCAACTTTTTCATTTTTACTTCATAAAATATAAAAGTGTAGTGATGCGAAAGCCAAAAAGTTTGGGTGAACGGGAATTACATCTCATCAGAGTTTACAGTAATTGGAATTTTGGGATGACACCGATAGAATTTTATACTAAATGGGAGGTTAGCTATGAGCAAATAGCTTTAATATGCGATCGCTCAGATTCTACAGTGCGACGTTGGTTTAAGCAAGGTGATAATCGGCGTTATCCTAACCGTAATGATTTGTTAAATCTGGCATTGATAGATTTTTTGTTGGAGCATTTTGAGGAGATTCCCGAACACTTACGACGCTTGTTATGTGCAGAGAATTTCTAACAATCCTTAATCATAAGCCCCTCAACTTAGCCCAAATATCCTAGGGGGCAGTCAGCATCGTGCCCTTACAATACCGTGAGATGAGCAAAAAATAAAACTCCGACAACAGAATATTTGTCAATGTCAAGTAGACCTTTTTCATCTATTACTCCTACATTAATGTGATTGTAAGCAATTGGAAAGCGATTTATCACAAGAATTACATCACTTGTAGGAGGTTAACATGAGCTATTTTGAGCAATTACATCCCTGGTGCATCATTCGCACTTTACCTAGCAAGGAGTGTATTTTGGTAGCGAGATTTCGTCGCCGGAATGATGCATTTGCCTACCAACAAGTGCTGCAAAGGAATGTGAATAATATCTGCTTTGTGGTGAAATTTAATCCCCAAGCTTGAATTGCTTGACTTCATCGGAAGTCGAATTAATGGAAACACCTTTGCTGATTTATTCAAATTTTTGAAAAATACCCAACTTAAAAAATTGGGTATTTTTCAAAAATTTAAGGAGTCTAGATTATGAAAACTACTCGTTTTTTAACATTTTTGGGAACTACTTCTGCTTTGTTAATGGGATTATCTTTGATTGCAACGACTTCCCAACCAGCAAAGGCTGATTGGTGGGATGTTGGCAAACAAATAATTGAAGATAATCTTAATGGGATTAGAGGAAATACTGTCGGTAGAATATATGACCAAACATTTATTGCAGAATTATCTTCTGAGGAAGTTGGACAGTACAAGCAAAGATGGGGAGGTAACTACAGTGCAAAAATTTCTGATTGGTGTAATGATACGGTATATCAAGCTGGATGGAGAAATCTTGCTGGGAACCAAATACCTTTTGTTAATACTACTTGGCGAGAAGAAAATGGTAAGGTCAATTGCTATGTAAGACATGCAGCACAATAGATTTAGTTTGATTTTTCCATAAATATTCACCTGTGATAAAGCATCGAAGTTTTAAAATTTAGATGCTTTCTTTGTTTTCATTAATTCAACTAGAGAGAATCTTTAAAATCTTCATATAGTCAAGGTTTTATTTCTATTTATCAACAGCACATACTTACTGGCATCTATTGACTCCAGTTGTTGATTAATTAGCTTCTGACCATAATGTATGGGATAAGTATTTCGATTATTATATAGTGGATTATGGTAATACAATCCCATTTTCGTGCGATTAACAAATAATATTTGATTGATGAAGTTTAGTACATTATCTATAAAAAATATTTGACGTAATTTGAGGATTTTTTAGACGTTCACCTCTTCAAAACAGTCTTTTTGTTGATTTTTCCTTTGACTTGCTTAAGTTAGTCCTTATTCGCACCAGAAACTGTTTTCAATTTAAAATCTAATGTTTGAATAATAACTATGAGCAACACGGAAAACAACTCGGTTTCCAAAAAGCTTGCTCTAAAGTTAGTCTAAATAGTTTGTCTTGAAAACAAAGATAATTCTTTTTCTAGTAATGAGGATAGGACAATGAATAAGAGCATTAATCGTTTCTTACTCGTAGGTGGTTTGATTACTGTTTCTAGTGTTACGGTAGCTACTCTACCTATTAATCCACCCGCACAGGCTGGCTGGGCACCTTGGGTTCAAGTTTACGTTACAGACTATTCTGAGGGGAATGGTCGAGACCAGGGAGAAAATGTGCGTGTTTGCCAAAATAAAGCAAAAGAAAGTGGTCGTCCAGACCGTATTAAGCGCTGGTGGTTCAATTCGACTTTCCGTGACGGAAAATGCTGGACACGAGTTCCTATTTGGGAAGGCTAAGTATTAGTATTAAGAAAGTTTTAATTCCTAATTGTAACTTTCTTTAATTACTTGAAGCTGGACAAAAATTATTTTTAGCAAATAAATATATTGTTTTGTCCAGTCAAATTTTTTGAATATAAATATGTGATACGAATGAAAGCTTTATTTTTTAAATAAAGCTGCATATTTTGTACGTCCATCTACCTGTTAAAGTAATGAGAAAACAAGTAATATCTATCGCAATTCTAGTTTCGTTTGGACTATTATATACTGCTCGACCAAGCCATGCATTAAATTTGAAAAAGTTATTTGACCCAATATTAAAGCGTGGTGTTTGTGCTGTAATAGGAGTGAATACTGGTGAATGTGCATCAGAACGACAAAATTCACCTTCACCTAATTACTCTAGTCCTAATTATCCTCAATATCCCGAACAGCCTTTAAACAACTCTAATCAAGCTGATGAATATCCTCAATATATGCCACCAAATCCCGAAGTACCTTATGGATATCCTCAGTACACTTCCCCAAATCCTGAAGAACAATAGCAATTCCAATACACTGCCCTAACCCCCAACCCCTTCGCTTATGGGGAACGGGAGCAAGATAAGTGTATTTCACCTATATAAAAACCGCTATATTTACAAGCCAGTGCTTTGAAGAAGTATCTTAGGGACTTCCAAAGAATAAATTATTCCAAAAAAAGGAAAAGACAGGTTGATTTAAAGAATGATAATCATTTTGAGGGGGAGAAAAGGGTTTGCCGTCGGCAAGCCCTTTTCTCCCCCTCATTTATGCATAAGAGTCTATACACTTGTTATTTGAAGTTAAACAGTGTAAATAAGGGATATTTTGCCGCTAAATAAATGTTGCTATTAAAATGAAATCACGTTTGTTTTACTACAACAAATATCAATAAACCAATTACCTAAATTTGGGAAAACTTCATGATTAGAATCGGTTAGCCGCTCAATCTGTTTTTCGATTTGAGCCATAGCTTTTTTTGTAAGCTTTACCCCATTCTCATAAGTTTCGTGTACTAGCTTAACGACTGGATGTTTCCCGTTCCATTTCATAGTGCTAGCAAAATTTAAAGCCGTTTCTAGTTCATCTAAAATACTCCCATTCCAATGATTTTCTAGTACTGCCCATGTCCTTTCTATTGGATTGTATTTACTATGATAGGGAGGATAATAAGCTAAACGTATATTTACTTGATGTTTGTGAGCAAACTCTACTATACGTTTCATAAATTGGGTACGCCGCGAACTATTCTGCGGACCATTATCTTGATTCAGAAGTAGTGTTTTAACTTCAGAAAAACGATGCTTTTCACAAGACCAAAAATCTTCTAGAATATCAACGATAAAATCACTTGTAACTTTCGATTCTGTAAAGTACAAAAATAACTCGTCAAGCTCTGGAAGAAATATTCCATAAGGAGTTACAGTTGTTTTCGGATTATAATCATGGTCTGATGCTTTCACCCCATCCCGGCTTTTACCCCCTCGGTCAAATGAGCCGATCTTAACACAGGCTTTTCCGTCCATGCTTAGACGTAAAACACTCTTATCTTCATCTGCATCTTTATTTACTACATCTAATTGCTCAAAGATTGCATCAGTTTGTGGGATTTTTTTTGAGGCTGAACTTTCTTTACCCTTCTGAGCTTATAACCTAAATTATTTAATTTGACTCGAATTGTTTCTGATGTATGTAACTTTTCATCACTATAACCAGACTTTTCGATTAATTGCTTTCTAACTTCGGCTGCACTGAGTCTAGTATATAGTCTTTGACTTTTAAAACTCGGATCGGTTTGACTATAGAAGTCAACTATTTTTTTGATATCTTCTAAAAGATTTGGCAGATGTTCTTCTGCTTTGTAACGTCCTTTGCCACTCATGTTATCAACACAAGTAATACCGCTTTTTAATTCTCTTGTTCCTTTGCGAATTGTGTCTCGATTCCATCCTAATTCTGATTGTGCAAGTCTTTGCCCTCCTAAACCTAAGCTTTGAACTGTCGAAGCCATAAATCTACGCTTTTCTGCACCTTTTAATTGAGATGCAGTTTCAATGAACAACTTTTTCAGAGAATCAGTTAATACTATAGTCACCAGTTGCTACACTCAAAAACTCAGTCATTATTCAAATTACTACAAAAGGGGGATGAAGGGGCTGCCGTCGGCAGCCCCTTCATCCCCCTTTAAAATGATTATCATTATTTCCAATGGAATAGTTTATTTTCTGGAAGTCCCTTAAGCATTGGGAGGAAAAGTTACAAACCGAGACGACATACCCACACACAGGACATAAGGTAGCATATCGTCGTTGTATGGAGTTGCTCCCGTGCGGGAGTATGTTGCTTGTTTGATGGGTGAGGTGAAGGTTTACCGTTCAATGATTTGTAAACTGTAGCCTAGTATACTGTTTGTGGGATAGACGCAATGGCTGAAACCCTTATTCTCTCGTTTTATCCCACAAATCGCTCTCTATATATGGGTTTGATACTTTTTGATTGTAGGTTAACTGCTAAGTATTATCAATTATTTAGGAAAAATTTTGCATCCCACAAAAAATGCCTGTAGAATAGCAACTAGACAAGGCTTTCAAAGACTAGCCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACTAGGAAGTTTTCGCTTGGGTATTGCTTAATTTAGCAGAGCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACTATTTAAGGCTATATCGCTTCTAAATTGAGAGACACTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACAAGACAGAGATATGTCCTCAAAGAGAAATGAGTTTGTCTCAATTCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACTTTTATCTGCTTTTGTAAACTCTCCCCAATGCAAAGCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACACTGGTTTGCCGCTTGAGTGGGCATAGTCAAAAAATCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACAGTTTGAGTCTCGGTCTCGGTCTCGGTCTCGGTCTCCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACTTTACACGATTCTGGAACGTTACTAACATCCCATCAGGACTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACTCGTTGAGTTGGTACACCAGCTGACTCTCAATTTGCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACATTAGGGTCTCTGTAGATCTTAAATTCCTCAGAGTACTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACGAATGAAAAGATTTTTACATCTTTTGCTGATAAAACTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACGTGTAAGTCACGGAATTTTCGGTTGAACTAACTAATCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACCTTTGATGTAAGAAAACTCATCACTAGCAAAAAAACTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACGGGGCTCTTAGCTCTGCCCGTAATTCGTCGCGGGACTTCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACGTGTCGCTGCTTTCAACTTCTGCTGCACAAACTACGCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACCTGAATTTTGTTATTCTAACCTCCACTCCACATGCTTTAGACTTCTTCGGAAGTTGAATTAATGGAAACAAGGAATTCCGTAGTCAGTGAACTGGGCTTTTTGACTTTAGACTACAAAAGTATAAATAATTTTGCGTAAGGACTTCCAGGAAATAGGTATAAATTGTCATTCTGAGTGAAGTCTTACGAAACGAATAATCTTGCGTTTCATGCGTATTTTGAGATGCTGAGTCCCAAGGGGACACGCTACGCGTAGTTTACTTCTCCGCTTCGGAGTACGTGCCTCAGCATGACATGTCAGGGTACTTTTCAAACATGCTCTAACTACTTAGTAAAGATAGAAATAAATAGTCATAATAAAATTGGTTTAAATACAATCTTTATAGAGAATCAAGCTTTTATCAAAAGGGAAAGGCTTTTGTTCTTTCCCCTTTTTTTATTGCTTATTACTTGTTACTTATTATTTTTTTGTGTCATAAACTTGAACAATCCCGCTACCAATTCCTTTTACTTTCTCTACCAACTCAATTGGTTCTATTACCTTCACATTTCCGCCAAATCCAACAATCCAACGCCACAAATCGAAGTCATGTAAAGACCATTTAGGTAATATTACCTGGAATCGATGGGGAAATTGTTTATCTTTTGTTGCTTTTAATGAAAAAATCGACTTGGGAAGATTATTTTTTGTACTGGAAACTGGGGGAGACATTTTGATTTTGGCAAATCGCTTTGTTCCTTCGGTAATGAACTTGTAAACATCATTGTTAAACCAAAGTTCTACTGTCATACAGGCAGTAATATGTACCTTTTGATCCTGACTTAAAAACTTACTTTGTTCAACTTCACTATTACCAAGAAATAGTCCAGCGCTGCCTTTTAATAGTGCTTGTAATTTTTGTAATGACTTCTCTTGTTCGCTTCGATAACGAGTTTTATTTTGCTGATTCCCCAAAAATAATCTATCTAACCGTTCAAATCGTAATAAACCTGGTTCATTGCCTCCAACGGATTCAAACCCCAAATACCAAGCCAAGTTAGAAAAAACGATTTGCAAAGGATAAGCTAAAAAGAAACTTTTGGGGTCATAATCATAGCCTCCACTACCTGAAAAACGGTTTAACTCCAAAACTTCACCATTAGAAATAGCTGCTTCTAATTTGGGTAAATTATTCACTAAAGCTGTGCTGTGGAGATATCGCGGATCGACTATAGAACGGTTTACGATCGCACGCACGGGATAGACTTTTTTATCAGTATCAATCAACTTGGTTTGTAACATTCTTTGCTTGAATGTCTCATAAAGCTCTAATGCTAAAGGGTCATCTAAACTCTGGGCTTGCGATCGCAGTGTCTCAAATACCCTGATTAATTCAGCTTGGGAAAGAATTCCCGTACCTGCAAAGTAACCATTTCGCATAGCAAATTCAGGTAATATTTGATAGGGTTTTAAGATTTTCTCAATATCTTTACGGAGAGTGTCTAAGTTATCACCACAAGTAATTCCCGCTTGTTGGAGTGCTTGCGCGAGGGTTGGTAAATTTCCGTCTCCAATGTTGGGTAGAAATGGGTTGTGCAAAATAAAACTAATTGTCCCAATCAAGCGTTGGAAAGGTTCTGTATCGGAATAGGAATGTGTGGGATGTGGGCAATGGAAGGATAAGGGAGAGGGAAGAGACAAAGAATTATTTTCTTGTTCTTTGTTTCCTGCAATAACCCCATTTTCTTCCAGCCATTGTAAGTCTGCGATGATTTCTGATGGATTCCCATAAATTCCACCATGCAACTTTGCCATTATTTTTGTAATTTCATCAATATTACTGGTAGTTTCAGGGATTTCACCTAAGATGTTTTCCAGTAATTTGGGGTTGGTTGTGTGTAAGTTGCCAATACCGGGATACTTAATAACGAGGGAAATTAGGTGCATTAATCGGTCAAAATCGAGCAATCTGCTGTAGCGATGAAAGATGATACCGTCGTGTTGAGTACGGTTGTTGCGGTTGGTGATGCGACGTTTTAAGCTATTGATGCGTTTTTCTATTTGTGCTGTAAATGCTGCGGTATCTGTTGGGAATTTGGTGACATCAATTTCTTCGATTGTTGCAAAACCCTCAGCGATGAGTGGGGGGAAGTTTGCCAGCAATTTGGACATGGTTTCGATTATTGGTTGGGGAACCTGTCGGTTACGGTTTTGGTTCCATTTAATACAGGTTTCGATGGGTGTTTTTAAGTACCATGCAATCCAACGTAGGGGTAGGGTTTCCCCATCCTCTTTAATTTTCATTAAAAAATCCATGCGGAAAGCACGTTTGAAGTTGGTTGCGTCGTAAATGACACTTTTTTTTGATGTTTGTGCTTGTTGAATTAAAAGAAGTGCTTGGTTTTCAATTTCGTTCCAGTTTCCTTGAATTGCTGCGTCTCCGTAGAGTGTGGTACGAATTTCGTCAGTGGAGATGATGACATTGTTACCGAGTTTTGCTAATGCAGCAGCGAAGGTGGATTTACCGCTACCAGGAACACCAATAAGGAAGTGACAGATATTCAATGCGGACATTGGGGTTTGTTAAGGAGAAAAATTTGTCAGAGGTATTTTACTGATGTTTCTATCCTATGTCCTGCATTTCTATCTGTCGATATTCTTGATGCGAATGACGAATTAATGTTTTTGTTTAAAACGTGTTTTATTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACAAGCGGCTGAATTTAAACCCGAAACCATCCAAGAATAGTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACGATTACAAACCTTGGTGTTTCTACCCAAATTGCGTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACATAATCAACCTAGCGGGATAAATCTTCCTTATTTAGTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACATTGAATTCATCCACCTCATCATCTGTATCGAAGGGTTTCCATTAATTCAGCTTCAAGAGAAGCTTTGAAACCAAAATCAACTGGCTAGCAACGAAGCTCAGATGCGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACTTCAGAGTTGGAAAATTTATTTGCCGTTTGTACTTGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACTTTCTTGCCACTTAAGATGCTGATAAGTTGTGTTGTGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACCAATATCACCCTTGGAAACTGGATCATCTACATAAAAGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACTTATCCATGTAATGTAATAATAGGTTGCTTTGAGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACCTTAAGGTAACGGCTAAGGATTATAAAGGAAATGAGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACCAACAAAGCAGTTGATTATAAATTGAGCTTACCAAGGGTTTCCATTAATTCAGCTTCAAAAGAAGCTTTGAAACCCCGGCATCTGGAACCCTTATAAAATAAGCTTTCCAGGAAGCCTTTTGGCAGACCTCAACTAAAAGTACCGTTTCAGGCATCGCTTGTCAAGAGAATCCTTCAACCCAATAACCGCAAAACCAAGCCCAGAGAGTATTTCAGAAGTTTGGCAGACCTCCTTTGAGACTAAAATAGCTGAAAGCTTTTACAGACAAAGGTTTCAACTCCCAAAATCCTATCACTTGTAAAACCCCGCTTCGGTTTGCCAAAAATAGGGTACTTTTCGATATTTTTCGAGAAATGTCATGGTAGCTAACACCGACTCTGGGAGTACCACTTGATAGATATTTACAAGTGCGATCGCTTTCGGAAATGTAATATAACAGGGAAATGCGATCGCGCCAGAAATTTAGATACATTCAGTATAATTCGTCATTCGCATGGAAAGTATAGCAAAATAAAGCATTTCAAAACAAGATAGAAAAGAGCAACCACAACTTAAGTAACTTGATGTATAAATCTATAAGCATACTGAGTAAAATAAGTTCTCCCACTATTTTGAGCGATCGCTTAATTGTAGCTTTGCTAATTTTGTAAACTACCGTATATATAAGCTTTCAGGCAATTATCTGGATTGTTTCTCAAAATTAGTAGAAATTATGTTAAAACAACTTAAGTATAAATACGATAAAAACTGTAGTCATAACTTGCAAAAACATGAACTATGCCCAAATACACTGCCATAACCTTCGCACCAGTGCAAGGATTCATCGAAAAATCCCGTAAACTTAGGGATTTATACGGCTCATCGCAGATACTCTCTTACCTCAGCCAAGAGTTACTCAACGAAGCTGGAAAAACAACAGAGGTGGTATCACCTGCAATTATCAAAATGCAGAAGGGAATGCCAAACCGCATTTTACTAAAAGGTGACTTTACAGAAAAACAAGCGCGAGATACCCTGTCATCAGCATGGAAGCGGATATTATTCGAGTGTCGTAGCTGGATAGGGACAAAATTACCCGAAAAATCATACGGTACATATCACTGGGAACGGGAATGGCAAAATTGGGGAAACTATGCGTGGGAAGTGTTTTGCGGTAGTGGGGACACAATCTCGGCAGCAATGGAAGACTTGGAAACCAAAAAACTCTCCCGTGACTGGATAGGAGTAAATTGGATTGGTGAGAGTTCCAGCTTAACAGGTACTGATGCGATCGCATTTCCCGGTTTAGGTGCGGAATCTAGAAACCCCAATAATCGCAAATGGAGCGCAGAAAAAGAGGAAATCAAAACTTTCTATCGTCGTTTAGCTTGTGTATTAGAAGGAATTTCCCTAGATAAGGAACCAGAGGGAAAATACATCGCACTCGAAGAAAAACTTAGTATTCCCGAATTAGTAAAACGTCTCGTTACCCACGAAGATATTGCCACAAGTTTAGGCATATCACCACTTGGTAATAGTTTCAGCGATATTTATCGTCGTCCCGAAAAAATCACAGAAACCGAAAAAGGACGATGCACAGGTTGGTTTATGGGGGATGGGGATAAAGTTGGCGATTATCTCAAAGATTTAGCGCAAAAGAGTGATGCAGAAGTAAAATTATTTAGCCAAGCAATGCGTGAATGGGGGAGAGATTTTGCTAGGGATTTTCCAAAGGAATTTGGACGGGTTGTATATGCAGGTGGTGATGACTTTTTAGGAGCTATTTATAGTGATAAAGATAAACCAAAAATTGAACCAGAACAAGTATATCAATGGTTATTAGAATTACCAAATAAATGGAGAGAACACAAGCAACCTATAAATGTGAGTGTCGGGTTTATTTGGGCAGCATCGAGCGTACCCCAGCGGGATATTTTACAGCATTGTCGAGAAGCGGAAAAAGTAGCGAAATCATTAGGAAGAAACCGGGTTACTATTCGGATTCTGTTTAATAGTGGTCAATATGTTGAGTGGACTTGTCCTTGGAACTATTTAAATATTTTAGATAAATATAAAGACTTGGATGGTAATAGTAACTGGAGTCATATTTATACCGATTTAGCACAGTTAGAAGCGCGAAATGCTTTTAATATCGATAAACGTACTTTTAATCGTAAATTTGCATTAGATTTTTTCGATATTTACTTTCCCGGAGAAGGTGAAAAATTGAGTAAAGACAATAATCTTTTAAAAAACATCGTTGGCTATACAGATGACGATGAAGAATATGAACGAGTTGAAAAAACAATTGACTGGATGCGGAGTTTAATTAAAGTTGGATTTCAATTATGTTCAAATACTTAATTAGTATTCATCCATTGGGATTTATGTATGGCTGTTCGGGAGAATTTCTATCACCAGAAAACTTGGTGGGACGTTCTGGTAGAAAATTTCCTCCGGAAGCTGCCACACTATCGGGGTTAATTTTTAGTATTAATAATGCACAAGAGTTATTTCCTAAAGATGAATTACGGGAAAATCTTGTAGTTGGATGACCATTTTGGGCTGAATCTAATAATAAACAAAATTTTTATGTTCCCATTCCCTGGCACAAAATTATTTCTAAAAAAGATGTAGATGAGTGGCACTTAGAAACGGGTAAATGGCAACGCGAAAAACAAGACGAAAAACTCGAACCAGAGTATCAATGGCAAACAATTTCAACTTGGAATTACCCAACGCAGGCATTTAAAAGTACCCTTAAAAGTGCTAAAAAACCAGTAGCTGCCAGTCCTTGGAAATTTACCTCGTTTTTACACCCCGATATCCAAAAAGAACAGCGTTGTGTTAAAAACGAAGATGGCTTATTTCTAGAAAATGCCGTTCAAATCCCGGATAATATTTGTTTAATTTATCTATCTACCTACCCAATTAAAAACGGATGGTATCGCTTTGGTGGTGAAAATCATGTTGTTGAAATTGAATGCGAAGAATTAGGCAGTATCGCTTTAAATTTGTTAAATAAACCTATTAACCGCGCATTTGCATTAATTGCACCTGGAGTTTGGGGTTCGACACGTTTTTCTTACCGCTACCCTCAGCATCAAGACTTTCCAGAACCAAAATTGATGCTAACTGACAAACCTATTAATTACCGCTACCGAGCTAAAAAACAACTAGGAAGGGGACGTTATGCTGTTCCCACCGGAAGTGTTTTTGTGTTAGAAGAACCACTCAACAAAACATGGTGGAAATGGGATGAAACATGGTTCCCTAATGAGGGAATTAGTTTAAAACGTATGGGTTGTGGATTGTGTTTGCCAATTGAAATTAAAGGTATTGAATAAAGGAGTTGAATAAATATGTATAAGAAAGCTTTCGGCATTATTGAAACCCTTGCACCCCTCCATGTTGGTGCAACCGCAGGAGAAGAAAGTGGGAATCTCAACTTAATTTTCCGCGACCAATTTACCCAAACAGGTATTATTCCCGGTAGTTCCTTACGCGGTCGTTTTCGTGCAGAAATGAGAAGTCAGGTAGACGAAAAAGAGGTTAGTTATTGGTATGGGGAAGGTGCGAGTTCGGAACAATCAGAGATTAATAATGAATCGATGGTTAAATTTGAACATGCTTCAATTGTTTGGCTTCCTGTGTTTTGTCCCGGTCAACCCATTGTTTGGGTTAGCAGTCCCCGACTATTGGAACGTTACAAACGTATTGCCCAAATTGATGCAGAAATCCCCAGTCTCTATGTTGCTTCTAGTAATATTAGAGCTAGAGAATCTCAGGGTAAAAAAACAATTTTCTTCAACTTAGGATTTTTGAATATTATTCGCAGCGAAAATTTATCTAAATGGTTTCCCAACGGAAAGGAATTACCTGCTGTAATTGTCGATGATAGTGACATTGCGATGATTCACGATATGGCACTATACCGTCAGAGTCGCGTGCGCTTAAAGGATAATGAAAAAGTTGTCGATGGTGGTGGATTTTTTAATACAGAAGCATTACCAGAAGGAACAATTTTAGTATTTCCCATTGCCATCCGCGACGATAAATCAAATAAGAAATGGCAACCTTTCCCCAACGACATTACAGACGAAATCTACCTGGGTGGTTTGGAATCGATTGGCTTTGGTCATTGCCAGTTAAAAATAGTCAACCGTAATTAACTTCTTCTTACCCCTGTAATTCGTATTAACTTTTACCTTGTTACTTACCCTATGAACTGGCAACCCTACAATTTAGATCAAGAAGCACAACGTTTAGTATTAGCTTTCCGCAATAAAGAAGGTGTAATCGGTCAATCCCACAAAATGCGTGTCACCGTTGCTTACGGATTAGAACGCTTTTGGGGCGAACATTTACGTCTTTTGGGTAAAAATGATGCTAAAGAACGGGAAAAAGGCAAATACTGGCAAAGTGTTTGGAAAGAATTTGTCCGAATTATGAAGCGAACTGGTGTGGAATTACCCTCAGACGAAATCAGCGATCGCAATACAGAACAAATCGAGGAAGTTGCCAAAAAATTATGGTCTCTATCCCTTGATGACCAAAAAATTTGTTTGTCGGTATTAACTCAATTTTGCGACTCATTAGTTTGGTGGACGCAACGATATAAAAAAGCAGGCGATCGGGAGGAGGAAGTATGACAAACTACAGAGAAATACCTTTGATGTTTCAAGCCCAAATCAAAGGTCGCGGTCAAATTCAATACATAGCCCAGCCAGAAAAAGCCTACAGATGGGTTGATGAGTGGGAAGAAGGAGTTGGCAACGATGTCTCGAACTTTAGCAATCGCGTTAGTACCAAAGAATATAAAATTACTTGGCGATTTATTTCCAATAGCGGACAAGATGATGATGTAATTCGTCCAGTAATTGCATCTGGGGGATTTCCCTATTACCCTGGTGCAAGTATGAAAGGTGCGTTTTTACGTAGCTGCACCCCCGAACAAGCTATGCATTATTGTGGTGGTATCGCTAGTAAAGCAGATTCCACAACAAAACCCGGTATATTGAGGTTTCATGGTGGCTATCCCAAAGACGCAACTTGGAAAGATAAAGAACTTGTAGATGTGGTTCATCCCCAAGCTGATTGGCAACTCAAAGACAGTAGCAGTCATTCAGCATTCATCCAAATATCCTTACATGAACCGACTTTAGTTTTTGGTATCTCTAGCAATATAAAAATCGAGAGTAGTGAGTGGGATACAATTTGGAGTATTTGGGAAAAAGCCTTAGAGCGGGGAATTGGTTCTCGTGTTAGTGCTGGTTATGGTCAACCTGTCAAGCACCCAGAAACGAAATTGCTGACAGTGGGATTAACGGGACAGGGGTTAGCATCCCAACTGATTAATAAAACGGGCGAATTTCGTCCTAATATGTTCAAAGCTGCCTTACGTGGTCATACCTTGCGCTTATTTGCCGGAATCACCGATGAGAATAGCGCAGAAGCATTAACTAGGGAACTTTGGGGTGGGTTTGCAGGTAAAGATGGTGCGGTTGTTGGAGATTTGGGGATTGTTTTTAACCCCCTCGAACTCGAAATGGATGGATATAGATACCGTGGAAATTCCATCCCTACTTACGAACTAAACAACGGAATTTTGCATATTTTATCTATGCGTTCCGTCAGCGAGGAATATAAAACAGAATTGCGATCGCTAGCTATTAAACTTATCCAGTTTTCCTTGTTATTAGGTGGTTTTGGCAAGTCTTGGAGACGAATTGACCATCGTATATTTTTCCCCGATTACTTGAAGAATAATCAAAAACCAATGATAGGCTGTCATTGGGAATTTCATCAAGGTGCAGAAAAATTATATATACCAACAAATAGACTGGAAAATATTTCTAAATTTTTCACCACTTTAGACGAAAAAATCCATCAGTGGATAATTGCCAATAACAAAAAGACTAGTAACAATTTAAGTCAATGGCGAGAAGTATGGCATCCGCAAAAAGTCCAAGTTTGGGCAAGAGTTGCTGAAGATGAAGATGATTCTTCAGCAGTGCATTGGTTTCATGGTGAATATAAAGAAGGTGGAACGATTAAAGGTTCGACTTTAACAGGACAAATAGGTCAAATAGGTAGAATTTGGCATCGCATGTATCCTCGATATAGCAAATTAAAAGATGGAACAATGCGACGTATGGGTGATGAATATATCGAACTACTAACTATATTCCCAGATACAAGCAACACCACTACACAATTTATCGATTTTCTGGGAAAGAGTTATTTCAAGCGCATTTATCCCTCGTAAGCTTAGACGCATCTAAATGACATCTTTTGAAACGTGAAAGCCTTACAGCAAGGTTTTTGGGATTATAAATTAAGCCCGTTTTAGCTTAATACGACACCCACAAGTATTTGGTGCGTTACGAACTCCGTTCTAATATAGCCTACTTCTTTCATGAAAATTTATCGAGGTTTATATTCTATGGCAATATGGATTATTACAACGGGAAATAGCGACGTTCGCATCAAAAAAGAGAATAATTGGAATACAATATTTCATACAATTAGGGATAATTTAGAATGCACAGATTTTGCTTCTCCTATTCCAATTAACCCCAATGCTATCGAAGAAGGATATACTCTACCCGCAAGAGTTTTAGGTGTTGCTTACAGTCAGATTATTGAGCAAGAACCAAAATATTTTGATGAATTAGAATTCCCTTTAATCGAAACGTTCTGCCAGAAATTAAAATCAGAAAAAAAATTAGAAAAAAAATCTCATAAATTAGAGCAAATATTTGTTTTAACCACAGACCAAAATAATTTATTCCCGAATAAATGGGATAGAATTAACGAAAAATGTCCCTACTGGCAAGATACAATAGAACTCCAAACTCTACTAGAAAAATACCTCAAAACTCAATTCGACATCCCCATTGAATTTATCTCCCTCTGTCCGAATTCTGATGAAGGATTAGATTATTGGGATGCTACTTTAAAATTAGTGGAAACAGAATTTTCTCAAAAATTTGCCAAACTGCAAGATAAAATCGTATACGTCAGTCATCAAGCAGGTACTCCAGCAATTTCTGCTGCCGTACAATTTGCGAGTTTAGGCATTTTTGGAAAAGTAGAATTTCTCGTTAGTAACCAATACTATGATGCCAGCTATAATCACCAAGCAAAAGCCAAAATTATCGATAGTTCCGAATATTGGCGTGGTTTGCAAATTCAAAAAGCCAAACCATTAATTAGAAACGGTTTTCCCAGCACTGCCTTAAAATTATTAGACGGAATCGATCGCATCGATAAAAATATAATTTTACAACTCGAACAAATGGTTGATTTTTTTAATCTCAAAAGTCAGTCTCAAAATACCAATCCAGATAGTATAAAGGAGGATTTTGGCATACCCAATGCTACCCAAAGAATAGTCGATGGACTCGATTTAATTGGATTTTTCTTCAAGCAAAATAACTATTTACCGGGAATTTCCCTACTTGCTGCTGCCCAAGAAACATTTCTCAAAGTAGCAATTAAAAGCGAAATACAAAAAAATACAGCAAATTATTGTGGTATTCCTGTTGCAGAGTTGGTAAAATGGACTACCAAAGGACTAATTTCCCCAAATAACGATGAATTACGAAACATTCTGAAACTTCCAAATTCTCAAAATATCGATAAAGTTAGAAACGATATTTTTGACCTTCTGAAATTTCCATATTCCAAGCATAATGACAGATTTTACCTATACTCTATCAAACAAGACTTAGAGTTTAGTAGGACGGGAATGCTGGAGTGGTTGCTAATTCTCGCACCTAATTTTAGAGAATGGGCACATTTAAGACAATCGAATCTGCGTAACCAAGTAATACATAACCTCAGAGGAATTGAAGAAGAGGAAGTAATCGCATACTTACTGGGACTGAGAGACTATCAACCAATACCAAACAATATTACTACCGCAATGGATGCATATATACAAAAAGTCAAACAACCCTTTATGCAAGCGATCGTACTATTGAAACTACCTTGCGAAAAAGGTAAATTGCAGGAAAGATTGAATGCGATCGCAGACTCTTTAATTTAATAACTCTGGCATACTGATGTTAAAGATTCTTAGTGCGTGTTCAAGAGAGCGATCGCTTTTGATTTATCCGGGCTAAATTGATTAGGCGTAGTTTACCACCGTAGGTATCGCATATTTTCTACGACAGCACCCACAAAATCCCTACAAGCATAATAAATTATGGTTCTTCGGTACTTGTTATGCTAAAAGGTTAAGCTAAAGCATAAAAATCTCTAAATAATTACATTGAAATATAGTTTTAAAGCTTTGCTAGCTTGACAGGTAGACATTATTTGTTGTTTTCTATAAAAACAACAAAAATAATTTTTACTATATCTGATAACCATGACTCAGAAAAGAAGTATAAAAGTTCTGACAGAACTTCTGGATTTAAAAGATATAAAAGTCACTTCACAGCGCATTTACAATGGAATTGGGATTATTTTACAAACTGAGTCAACAAAATCATACAGTATTTGCCCTCATTGTGGGACAAAAAGCGAAAAATTACATCAAAACCATAGCCATATTATTAAAGACTTACCTTTTAGTGAGAAGCCAGTATTCTTAGAAGTAAATAGACGACAATTTAAGTGTTATCAGTGTCAAAAACCATTTAGTGAGGAATTGTATTATGCAAAAAAGAAGAGGACTTACACAAATCGACTAGCACAAAAAATAATACAAGATGTTTTAGAAAGTGATATTCATAGTGTCGCATCAAAAGGCATTGTCACAACTGAAGAGATAGAACGAATGTTAAAGGATGCATCGGAAGAATTATGTGATTCCAAACCATCAAACTTAAAAAGGCTTGGAATTGACGAAATTGCTTTAGTCAAAGGCAAAGGTGATTACTGTGCAGTATTAGTAGACTTAGATGCATCTAAATTACTTGCGATTTTGAATGGAAGAACACAAGATAAAATCAAAGAAGCTCTTTCTGGATGGGGATTAGAAGTCTTACAGCAAATAGAAGAGGTCAGTATTGATTTGTGGCAAGGTTATAAAAACTTAGTTATGGAATTAATGCCCAATGCCCAAGTAGTTGCAGATAGATTTCACGTTATGACACAAATAAACAAAGAACTAGACACGCAAAGAAAAAGGGAAAGAAGAAGTATTGAAGAGCAAATCAAAGAAACCAAGTCAGAATCAGAAAAAGCTGAGTATGAAATCATTTTAGCTGGCTTGAAAAATAGTAAATATTCCTTACTTAAGAATGAAGATAATTTAACTGACGAACAAGTAGTAAAGCTCAGAGAAGTTAAAAGAGTATCTCCAGTTTTGAAAGAAATGCATGATTTTAAAGAAAAAATTAGAAAAATATTTAACCTGACTGATCATTGGTACACAGGAGTTTTTAAGCTAGGAATGTGGTTGTCAAAAGCAAAGAAATACTTTCCTCGTAGCAATAATACTATTATTCGCTGGTTTGATGAAATTATCGCTTATTTTGATAATGGAACAACAAGTGGAACAGTAGAAGGAATTAATAATAAACTTAAGCTGATAAAACGCTCTGGATATGGATTCAGAAATTTTCAAAATTTCAAGATTAGATGCTTGTTAAATTGGACTTAGTTCATTAGTATGGCATAACAAGTACCGAAGAGCCTAAATTATTGATGGCTCACGCCAAAAATGCGAGTGAAGTCAATGGAATCAACCTGTGAACATCATAAACATCACATTCACTCACCCATTTGCCAAAGCTCCCAAACATGTTTTTGGACAACAAGTCACAATTAAAAGTAACTGCGATCGCAAAAAATGGGCAAAAGGTCAAATTACGGGATTGCGATTAGATTATAATTCCCCAAATACCTGGAATTACACAGTCGTTTTTGACTATCCACAAGGCTTTTGCGAAGAATTTACCGAAGAAGATTTGGCAGCAGTAGATGAATTAGTTTGCTCACAACTGTTGTTCAAGTAAAAATGACTACTATGAATTTCTAATAATAAAAACCTTTGCTGTTGGTAATTTTGCCAGCAGCTTTAATTTTGCGGCTAACGCCTACAGGTGTGTGAAATCCGTAAAATCAGGAATTTTTCAACATGAAAACGCCGCAACAAATAGAAGCCGCACTTAACCAATTTACTGGTTCTACGACTCTCTACAAACACTGGCTAGGCTTAAAATATACAGATGGCATCAAATATTTAGCCGAAGAGACTAGCTGCTATTGGCTCTTGGATGCAATTTTCTCCCATCAAACTAAAACCTTTCTCTCTAATCAAAATTTGCGAGAATTTCAAATCTGGTATTTGCGAGTTGAAAATAATTCTGGTGTTTTGATTTGTGAGTGGGATACAAATCAAGAAGTATTACGACAGGAAATCGAATACACAGATTTTTCACTAAGCCATATCAAGCTTTATTTAATAGAAACAGTTCTCATGCTCCCCAGCGAATATTAAACCACATCAAAGTTATCAATATTGGGAGAATATTTATGTTACAAGCAATTAGTAGTGGGCAAACATTTGTCACAAATCTCGAACAATTTATGACCAAAGCTGACAAATTTATCAAAATCTACTATGCAGGTATCAGTGAAGAAAGCAAAGTTAGAGAGATTGTGCAAGAACTACAAAATTTGCTATCAGATACAGACTTACAGCAATTGGAAATTGATTATCAGCATTATTGCGAAATCAAAGACTTGATGTCTGACTGTGACGATTCTGCATGGTTTTAAAAAGAAGGCAGATGGCAGTAGAGGTAATACAGAAATGCTATTTTTCTTACCTAAATATCTTGAGTTTTAGACTTATTTCCTTCTACCATCTGCTTTTCAAATCCTGCATTCTTCTGGCTAACGCCAAGAGAGAAATGAAGAATTAAAGGATGTTTTCATCATGGCTACACGTAAATCCTCAACGACTACTTTTAACGCAATCGATGATTCAATATTAGGTGATTATGCTGTAAATAATTACTCCGAACGAGTATATTCCAAAGTCTACTACTCCATCCGTGAACTTTGTGGGCTTGTTGCCAAGCGTTCCCTAAAAGAGGCTTTCGATTGGAATAATTTCAAAGAGCGCTTTACAAGTGACTTCGGCAAAGTGGAAGAAAATCGATATTCCCTAGAACAATTATTGGAATATGCTAACCGCAAATTTGGTAAAACCCTTGAAGATTTGATAGTACAAAATCAAATTTCTTGGCAACGCAGACAAGAATATACCGAACGGAGCAATATGAGTTATCAATCCAAAATGATTGAAGATAGCACTTGCTACTAATATGAAAAACTCATAGCTAAATTTTATAATCCTCCAGTGATTAATCGTTGCTGGAGGATTTTGATTAAAAGCATTCAATCGCTTCAATAAAAATGCTTTTAGCCCTAACTCAATAAATACAATACTGCTAGAAATATGCGACAAAATAGTTATATCGCGTGGGAAGGTAATTCTCTGATTGACGGTTCTCCTATCGTTTTAATTTTGACTGGCTTCGTCTTTCCAAGCTTCAATAAAAAGACAGGAACCGAAATGATCCAATCGTGGATACTACAGCAAGAATTTGTTCCAACTCACGCTGCAAAAGCAGGTTTTGACAAGGGCATATGCGGCTAATGTCCACTAAAAATGAGTGAGATTGGAAGTTGTTATGTTAACTTATTGGGTGTCAATCGAGTTTACAGAAAATATCAATATGGAGGCTATTCAAAACTTAGCAATAATGAAATTGAAGTTCTCAGAAGATATCGCTATCCAATTAGATTGGGTTCTTACGGCGACCCGACAGCAACACCATTAAAAGTGTGGGAGCCGATTATTTTAGCATCGGGTAAATATACAGGCTATACCCATAATTGGCGGCGAACAAATAGCTTGTGGAAGCAGTATTTAATGGCTTCTGTGCATAGCATATCAGAAGCTCAAGAAGCACAAAATTTGGGATGGAGAACTTTTAGAATTATCGCTCCCGACGCACCATTGAGCGATAACGAAATACTTTGCCGTCATACCGAAGATGAACGTATTGATTGCAGTTCCTGTCTCTTGTGTCATGGAAGCTCGTCTAAACCAAATATTGCTGACAAAGTTCACGGCTTAAATTGGAAAGTATCGAATTTTCTCAAATATCTTAAATCGACATCAAATTAATTGAGGGAAGGTAGAAATAGAAGTAACTAAAATACTCTTCTGCCTTCCTCAAATCACAGCATTAAGACAATACAAATACAATTCTGGGTAAAAATCATGGCAGAAGTATTGAGTGAACCCCAGTTTCAAATATTAACTCATCAATATACGGGAGAGAAAACGGGAAGAATTTATTTTCCAGCTTTGTTTTTAGCTGAGTTTCACACAAGTGTTACTCAATGGTTACAGCAACAGGAAATTATTTTTGAAGAAAGAGACTTAAAACAATACGGAGATGCTTCGTTCCGATTATATTTCAAAACTTCTGATGAGTTGGAACGAGTGTACTTTCAATTAATAACAATGACTTCCACTGCTTGTAATTAGTTGAGCCATCATGGTCAATAAATAATGCTAAACCAGTTGATTTAATCTGAATATCAGGATGAGTTTTGCGATGAAATCAAGATATCAAAACTTTCTTTGCGATAACCGCTATACCACCATACCCATTCCCCAATTTCAAGCAATTTCCCCACAACTACCGGAACGAGAAACTATCAAACATACCCTCATTGGTTCCACTAAAGCCGTAACAGCGACAATTCGACTTTTAGATCAACTCGGATATGCAGATATGCTTGATTGGAGTCCTTTGGTACCAACTGATAATCCTGGGCAGGTTATGAGCATATTAGTACGTGCAATCGCTATTCAATAACAGGCAATAAGATGCTCCTTTTGAGGAGTATTTTTTTGCGAATAAGCAGAGCTTAATAGCTTAATACGCTATATAGCACAATAATACTAAATAATTTTCACCAAATACTTCCACAACAGCGAATCTGCAAGTATAATATTTTCGCCATCTTCCAAAAAGTAATGTCCAGCGCGTACCAAGCTAACCAACCATCAAGTAATGCCGCTCCCAACCAAGAATCAATCACGGGGGTGGTAGAACGTTTGACTTTTCATTCCGAGGAGTCGGGTTATACGGTAGCGCGGTTGCAACGTCCCAGGGTATCAGAATTAACTACAATCACTGGTAGCTTTGCAGGCATTCAACCCGGACAAACACTTGAATTAAATGGCTTTTGGCACGAACACCCCCAATATGGTTCGCAATTCCAGGTTGTTAACTACAAAGAAACTAAACCAGCCACAATCACGGGAATCGAAAAGTATTTAGGTAGCGGCTTAATTAAAGGAGTTGGTCCCGTTACAGCCAAAAGAATTGTCGCCCATTTTGGCGTGGAAACGTTGGATATCATCGAAAACCAAATTGATCGCTTGCATGAAGTCAACGGCATCGCCAAGAAGCGAATTGCCATGATTCAAAAAGCCTGGAACGAGCAAAAAGCCATCAAAGAAGTAATGATATTTTTGCAAACACATGGCGTTTCCACTGTCTATGCAGTCAAAATCTATAAAAATTATGGGGATAAATCTATTGGAATAGTCACAAATAACCCGTACCAACTGGCAACCGATATTTACGGCATTGGCTTCCTCACCGCAGATAAAATTGCCCGTAACTTGGGAGTCCCTGAAGATTCCGAATTTCGCTATCGTGCTGGGATTACCCATATATTAAATGAAGCATCGGAAGACGGGCATTGCTATTTACCGCAACCCGAATTGATAGAGAAAGTATCCCAATGTCTCAAAACCGATGATCATCAACCAAACGAGGATGCGATCGCACAAATCATCAAAAATATGTCCCTCGCAGACGAACTAATTCGGGAAATCTCTCCCGATAAAACGTTACTTTGCTACAACCCTGCATTTTTCAATACTGAGAACAACTTAGCATTGCTAATTGCCCAGCGTTTAAGAAGCCCCATCAATCCAGACATGCAACGTGTCCGCACATGGCTTGCACGCTTTACCAAAAGTCGCAAAGTTGAACTTTCACCCCAACAACAAGAAGCAGTCGAGATGGCAGCATATTCACCTATCTCGATTTTAACTGGTGGACCAGGAACGGGGAAGACCTTTAGTGTGCGGACTATTGTGGAACTGTGGAAGGCGATGGGAAAATCAATTGCCCTCGCAGCACCTACTGGACGAGCAGCACAACGATTAACTGAAATGACGGGATTGGAAGCAAAAACCGTACATAGATTGCTGGAGTTTGACCCCAAGAATATGGGTTTCAAGAGGGATATGAAAAATCCCCTGCCACAGAAAGCAATTATCATCGATGAGGCAAGTATGTTGGATTTGTTTTTGGCATACAGTTTAATCAAAGCTATATCCGAAGACAGCCAAATTCTGGTGGTTGGTGATAATGATCAGCTGGCTTCCGTTGGACCAGGCAAGGTGCTTGCAGATTTAATGAATTCGGGAAAAGTACCCGTAGTACGTCTTACTCAAATATTTCGCCAAGCTCAAACAAGTGCGATTATTAGAAGTGCTCACCAAATCAACCTTGGACAATATCCCAATATCGAGCCAATTTCCGAGACTCCTCAATCTGATTGTTTGTGGCATGGTGGTGGGCAACAACCAGAACATGGTGTCCAAGCAATTAGTGAGTTGATAACAGATTTTATTCCTTCCCTTGGTTTTAATCCTGCCATCGATGTGCAAGTATTATCGCCAATGACACGGGGGTTGGTGGGTACACGCAATCTCAATAATGTGTTGCAGCAGTTAATTAATCCCCCAAGTCCACAGAAGCTAGAGGTTACGAGGGGTGGGACAGTTTTTCGAGTTGGGGACAGGGTGATTCAACTTACCAACGATTACAACCGCGAAGTATTCAATGGTGATGTCGGATTTATTACCAACATTGACACTGAAGAACAGGAGGTCATCGTACAGTATCAAGATAGGGATGTAACCTATGACTACGCAGATTTAAACGAACTTGCTTTGGCTTGGAGCGTTACTATTCACAAATCTCAAGGTTCCGAATATCGAGTTGCAATTATGCCCCTGTATACTCAGCACTATATGATGCTTTCGCGTAACTTAATTTATACAGGATTAACTCGTGCGAAGGAATTAGCAATTATTGTCGGTTCCAAAAAGGCGATTGGGATGGCTGTCAGGTCGGTTAATCAGAAGGAACGGTATACCCAACTGCGGGAAAGATTGGCTCAAATTTCAACAATTTCATCATGATTGTAACTATTGTTGAGGTGTTGAGGATCAACAGTGTATTTTCAGGTAAAACTTTATTTTCCGTAAAACCATAGGTTACAACTGTAGGAAATAAGAATCAACCCAATGTGAACCGTCTTGAAAGTTCATGCTATTAACAATTTCGACTACAAATCAACCAGCAACCGACCTGGGTTATTTGCTTCACAAACATCCCAACCGTTGTCAATCTTTTCCCCTTTCTTTCGGGAAAGCACATATTTTTTACCCTGAAGCTAGCGAAACCCTTTGTACAGCAGCATTGCTACTGGACATCAACCCCATAAAACTAGTGCGGGGAAGGGGTACAACCTTAGAACACTACGTTACAGATAGACCATATGTTGCTTCATCGTTCCTTAGTGTGGCAATGTCCCAAGTCTTTAGTACGGCAATGGGAGGACGGTGTAAAGATAAACCCGAACTAGTCAACACTCCTATTCCCCTGACGGCAAAACTTAGCGTTGTTCCTTGTTGGGGCGGTGAAAGTATTCTCCGGGAATTATTTGAACCACTAGGTTATACCGTCATCGCAGAAAACCATCAACTTGATGAGAAATTTCCGGAATGGGGAAGCAGCAAATACTACACAGTGGAACTGACAAATACGATTCCGTTATCGGAACTCCTCAGTCATCTCTACGTACTCATTCCCGTTTTGGATGATGAAAAGCACTACTGGGTAGGTGAAGACGAGGTTGAAAAACTGCTGCGTCATGGTGAAGGTTGGTTAAATACCCATCCAGCGAAGGAAAAAATCACCCGTCGCTACCTCAAATATCGCGGCAACCTTACCCGTCAAGCATTGGCACAATTGGCAGAAGATGATAATTTAGACCCAGATGCTACAGAGATAGAGCAAACAGAAGCAGAGATTGCGATCGAAAAACCGTTGAGTTTGAATAAGCAAAGAATGCTAACGGTTATAGATGCATTGAAAGCGAATAATGTCAAGCAAATAATAGATATGGGTTGCGGAGAAGGAACTCTGTTGCGATATTTGTTAAAAGAATTATGCTTCGATAAAATTACAGGTGTGGATGTTTCCTATCGTGCTTTGGAAATTGCGAAGGAACGAATAGATAGGTTACATTTACCGCGAAATCAATGGGATAAGTTACAGATTTTTCAAAGTGCATTAACCTATCAAGATAAGAGATTTCAAAATTACGATGCGGTGACTCTGGTTGAAGTTATAGAACATCTAGATTTACCTCGTTTGAGTGCTTTGGAAAGAGTAATTTTTGAATTTGCTCATCCGAAATTAGTTGTTGTGACTACACCAAATATTGAATACAATATCAAATTTGAGAATCTACCCGCAGGTAAATTAAGGCATAAAGACCATCGTTTTGAATGGACAAGGGCAGAATTTGAAAGTTGGGCAAATTTAGTTGCAGAAAAATTTGATTATACCGTATCTTTAAAACCGATTGGGGATGTGGATATAGAAGTTGGTTCCCCAACCCAAATGGCATTATTTAAAGCTGCAAATTAATTTATTTAATTGCTAGAAATTATGGAAATTCTGGCATTCATTTAATTTAGCGATCGCAAATCATGGAAGCAATCATATTTGTCGGGATTCAAGCTTCCGGTAAATCGACATTTTACCGAGAAAATTTTCTCAATACCCATATTCGTCTCAATCTTGATATGCTGAAAACTCGTCACCGTGAGCAAATATTCATTCAAGCATGTATCGAAGGGAAACAGCCATTTGTGGTGGATAATACGAATCCCACACCAGCCGAAAGAAGCCGCTATATTGTCCCGGCGAAAGCAAATCATTTCCAAATTAAAGCCTACTATTTTGATTCACCCTTGGAGGAATGTAAACAACGAAATAACCAGCGTCAAGGAAAAGAAATTATTCCTCTAATTGGACTATTAGGAACACATAAAAAGTTGACATTCCCAACTTGGGAAGAAGGATTTGATGCAATTTATTCTGTAAACCTCGATATTAATAACTCTTTCCAAATAGAGGAGTGGAAAAATGAAATTTGACGAATTAGATACGAGAATGCGCGTATTTGAAACAGCCCACGACCATTATGTATTACCGGGTTTATATATAGTCGCAAGATTAGATGGGCGGAGTTTTACCCGTCTTACCAAGGAAGTGCATCAATTTAAAGCACCCTTTGATGAAAAATTTCGGGATATGATGCTCGATACGGTAGAGCATTTGATGAATTGCGGCATTGATATTATTTATGGATATAGTCAAAGCGATGAAATATCCTTACTTTTTGCTCATGATGAAAATACTTTTAGCCGAAAAGAACGTAAATTAAACTCTATTTTAGCAGGTGAAGCTAGTGCTAAATTATCTTTAGTTTTAGGAGATGTTGCTTGCTTCGATTGCCGCATTTCCCAACTTCCTAATATTACCGAAGTTGTCAATTATTTTCGCTGGAGAAATGAAGACGCACATCGTAACGCACTCAACGCTCACTGTTACTGGAGTTTGCGAGGAGATGGGAAAACTGCTAGACAAGCAACAAGTATGATGTCGGGATTATCTGTAGCTGAGAAAAACGAGCTTTTATTTCAACATGGAATTAATTTTAATGATTTACCAAAATGGCAAAAACGTGGCACGGGATTATATTGGGAAGAATACGAAAAAGACGGATTTAATCCCCAAACAGGACTAAGTGTTAAAACAATTAGACGCAGAATTAAACGGGATTTAGAATTGCCCATGAAAGAAGAATATAGCGAATTTATTCGTACCTTCCTCTCATGTATTCTCAGCGTAACTTTGGTGTAAACCTTCACATTCCTATATGTTAAAAACACATATTCAACCTCTATGAAAATAACTATCCCCGAACTATCTCTAGTCATATTAATCGGTGCATCTGGTTCCGGAAAATCCACCTTTGCCCGTAACTATTTCCAACAATTTGAAGTTATCTCATCAGACTTTTGCCGTGGTTTAGTATCCGATGATGAAAACAATCAAGCATCATCAAAAGATGCTTTTGAATTACTCCACTACATCACCGCAAAAAGACTCGCAACAGGTAAACTAACCGTAATCGATGCCACCAACGTCCAACCCGAAGATAGAAAAGAATATATTAAACTAGCACGAGAATATCATTTCTTATCAGTTGCGATCGCACTCAACGTTCCGGAAGAAGTTTGTCATGAAAGAAATGCCCAACGTTCAGATAGACAATTCGGTTCCCATGTAGTCAGACGACACACCCAAGCGTTGCGAAGAAGTTTGCGAGGTTTGGAAAGAGAGGGTTTTCGTTATGTTCATGTTTTAAATTCTTTGGAGGACATCAATAACCTGGAAATTGAACGTCAACCACTTTGGAATAATCGCAAATATGAAAAGGGACCATTTGATATTATTGGGGATATCCACGGTTGTTGTGACGAACTTGAAGGATTATTGCAAAAATTAGGATATCTGAAGAAACCTAGCATACAGTCAGATAAATTCTGGAATTTTCCTCTGTACCACCATCCTGAAGGACGAAAAGCAGTATTTTTAGGTGATTTGGTAGATAGGGGAAATCGCATTCTCGATACGGTAAAACTTGTCTACAACATGGTACAGGCAGGTACAGGTATTTGCGTTCCCGGAAACCACGAACATAAATTGCTGCGAAAATTGCGGGGTAAAAATGTCCGGGTAAATCACGGTTTGGAGCAAACTTTAGCTGAAATTGATTCCATTCCGGAAGATATTCGGGAAACCTCTATTAAAGAACTACGAGAATTTTTCGACTCCCTAGTAAGTCATTATGTCCTCGATGGAGGTAACTTGGTAGTTGCCCATGCAGGGATGAAAAAAGAAATGCAGGGAAGGGGTTCTGGTGCAGTGCGGGAATTTGCCCTGTATGGAGAGACAACCGGGGAAATTGATGAATTCGGTTTACCCGTGCGTTTTAATTGGGCAAGCGAATATCGCGGTGATGCTATGGTAGTTTATGGACATACCCCCGTACCGGAAGCGGAATGGTTGAATAATACAATTGATATCGATACAGGTTGCGTTTTTGGTGGCAAATTAACTGCGTTGCGCTATCCCGAAAAAGAATTGATTTCCGTGGATGCAGCTAAGGTTTATTGCGAACCCGTCAAACCCTTGGGTATTGCTAGTAACAGAACTGCACAGCAAGAAATTGATGATGTATTGCATATCGAAGATGTCCTGGGTAAACGCATCATCAATACCCGTTTGCAGAATAACATTACCATCCGGGAAGAGAATAGTATTGCTGCACTGGAAGTAATGAGTCGGTTTGCTGCTAATCCGAAATGGTTAATTTACCTTCCTCCCACCATGTCTCCGGTAGAAACTTCCCAATTACCGGGATATTTGGAACGTCCCGAACAAGCTTTTACCTACTACCAAAACCAAGGAATTACGGAGGTTGTCTGCGAAGAAAAACACATGGGTTCCCGTGCTGTAGTTGTGGTTTGTCGGGATGAAACAGCCGCAAATCGACGTTTTGGTGTGATTAATGAAGGCATCGGGATTATCTATACCCGCACAGGAAGGAAGTTTTTCAACGATGAGACTTTAGAAACCGAATTATTAACCCGTTTGAATACCACACTCACCGACAGTAACTTTTGGGAAATATTTAACACCGACTGGGTATGTCTAGACTGCGAATTATTACCCTGGACAGCAAAAGCTCAAGGATTATTAACCAAACAATATGCACCTGTGGGAATGTCATCAAGATTAAGTTTGGGAAATGCGATCGCACTTCTGGAAAAAGCCCAAAATCGAGGTGTAGACATATCCTCCCAACTCGATAGTTACAAACAACGGGCAGAAATGGCGAATTTATACGTCGATGCTTACCGTCGTTACTGCTGGAACGTTGGGGATATTTCCGACATCAAATTAGCTCCATTCCATATTTTAGCTAGCGAAGGGGCAGTACATACAGATAAGACCCACACCTGGCACATGGAGGAAATCGCTAAAATTGCCAAAACAAATCCGGAATTATTGCTAGCAACCAATTATCAAGTAATCGATTTAACAGATGTTAACAGTAAAAATAGGGGAATTACTTGGTGGGAAGAAATGACCGCAACCGGGGGAGAGGGAATGGTTTTCAAGCCTATGGAATATATCGTCAGGGGAAATAAGGGAATTATTCAACCAGCGATAAAGTGTCGCGGGAAGGAATATCTACGAATTATCTATGGTGCCGAATACGACAGCCCAGAAAACTGCGAGCGTCTGCGTCATCGAGGACTATCCCACAAACGTTCCCTGGCAATGCGAGAATTTGCCTTGGGAGTCGAAGCATTATCAAGATTTGTGGCAAAAAAACCCTTGCGGCAGGTACACGAATGTGTGTTTGGGGTACTCGCATTGGAAAGCGAACCCGTCGATCCAAGGTTGTAATCAGTTTGATATATGCCAAGGAGGGAAAGGATTACGCTGACTGCGTTAAGTTGGGAAGAAAGATTATGTGACGGTATCTCAAGGAGATTTAAGTTGCTCTATAATTTCTGTTAATTCCATACGACCAATTAGATTGATTTAAAAGTTCTTATACAACTATTTATTTTCTCACTTTTTGTCCGTATGGGAACGAAGAATTTGTGCTGAAAATTAATCCCACCAATAGGAAATAACGACTGCATCCCTATCGCGTTGTTTATCCTCTCCCCATAATGCCCCTTCAAATCTATATCTCAACTGCCGCTTGAGTCGAAAGCTGTAATTTTCATCCGCACCATCGGTTACATCCACCGAATCTGCTTGCCATTTCTTCCCAAAATCTACTAGTTTAGACACCTTTGTATCTTGATTTTCTGTGAGGATATACAGGGTATCTGCCGGATAGTTAACAAAGTGGATAATACTATCTTCTGGCATTGGACGATAATTAGCCATCGCAATCAATGTATCAATTACACCACCAAAACTTAAACCATTTTCATCTGGTGCAAAAATTGGTTTTGTAAACAAAAAGCTAACCCACAATTCTGGATGTTGGGAAAGGTCAGTAATTACTTGTTCTCCATAAAAATTATTGAATTGACGCTGCCAAACTAAGGCTGCAAATAGTTCTTGGGGAGAATAGGATTGAGCGATAGCTTGAATTTTTGTTAAGTCCAACATGGTTTTATCCCAGTTTCAAAGGCGATTTTGGAGATTTGGTATAACGATGTGCCAATCTCTGAATCGCAAAGAAGGTTTCGCTGTTGAAAAACACATCGATTTATCTTTATCAATCAGAAAAGTTATCGACTCGAATATCCCTCCAAATATCAGAAATTTGCCATCCTGAGTTACCAATGGATTGAACTATGGGGTTATCCCGCGCTGGAATATAATTAGATTCTGTATTTTCTATAATTAGGTGTTTTTGCTCTTCTCTCACCTCTGGAATATCCTTAGCATCCGGTTGAATATTTTGTTCTTCATCTTCTATTTTTTTAATTTTAAGCAGAAGTTGCTGTTCCGATTTTTTGATTAGTGTCATATCTGAATTTTAAAGTAGGAATAGGATTTAACTTGTTGTATATCTGCGAAAACACAGATTTACCATTTTACATCTAATGGTAAAACATCACGCACTTTAAGAAAAGTTAATATTTCCAATCCCAAGTATGAGATAAAAATATCACAGCCCAAAACAACAACTATAGGGTTAAATATTACTAGCCACTTTTGGGAAGATTACTATAAATACCTTGTTTCTGCTACGCTATCGCCCTGCCAATTTAAACGTCCTGCCAAATCGGAAAAATCGTAGGGTTTTGTTTGGGGAGTATCTGGGATGCTTGGATTCACAACAACAACTACATCAACAGTCAATACCTTCGCCAAAGTAAGAGGATGAAGAGGAAGAGGTAGGGCGTTTCGTAGTAGAGTTATTGTCTCTCACAACGACAACTCAAAAACCACTATGTGCGCCCATGTTTGACATTTTATCATTGTTACAGTGCTTCCTGCCGCAGATAAATGCTACAACGATGAAGCAATTGAACCAAATAATCTTGGCAATGTTAGCGATGAGCGGGCGAGTCACTATGTTGGGAATTTCTCGTTGGACAGGTAGTGGTGGTAGTTATCGGACGATGTTGAGATTTTTTCATACGGTAATCCCTTGGGCGACATTGTTTTGGCTATTTTTCCGCAAGCATTTGTTCCGTGCAAATGAGGTTTATTTGCTTGCAGGAGATGAAGTTGTAGTAAGTAAATCTGGGAAAAAAACTTATGGGTTGGATAGATTCTTTTCCAGCCTAGTAAGTAAGCCAATATCAGGGCTATCTTTCTTTACATTATCATTAGTAAGTGTTGAACAAAGGCACTCATTTCCGATTCAAATAGAACAGGTAATAAAGAACGATATAGAAAAAGTAGTGTATCGCCAAGACCAGAAATAAAAGCCAAAGAAAAACGTGGACGTGGACGACCAAAAGGGAGTAAAAATAAAAACAAGACCGAAGTAATTCTCACATCTGAATTACTCAGAATTAAGAAGATGATTAATGAGCTAGTCAAGCTGGTAGCTAACTTTATCCCACTGACTTACTTAGTCTTAGATGGTCATTTTGGAAACAATAATGCTTTGCAGATGGCTCGACAGGTCAACTTACATATAATTTCCAAGTTACGCCACGATTCAGCATTATACATACCTTACCAAAATCCTGACCCTAATCATCGTTCACGCCGTAAATACGGAGATAAACTAGACTGGCGTAATATTTCTGATGAATATTTGCGTCAAAGTAGTATCGAAGAGGATATCCAAACCGATAGTTACCAAGCTACTTTACTGCACAAAGAATTTGCCCAGTCCCTGAATGTAGTTATTTTGGTGAAAACAAATCTGAAAACTAATGCTCGCAGTCACGTAATTCTGTTTTCTAGTGACCTAAAGTTGTCATCTGAGAAAATAATTGACTACTACAAACTACGCTTTCAGATCGAGTTTAACTTCCGTGATGCCAAGCAATTTTGGGGATTGGAAGACTTTATGAACATCGGTCAAACTGCGGTGACTAATGCTGCTAATCTAGCATTCTTTATGGTTAATTTATCTCATCATCTTCTCGCTGATTTCCGCATCCTGAATCCTGACTCCGGCATTATTGATCTTAAGGCTCATTATCGTGGCTTTCGATATGTCCATGAGATCTTAAAAATGCTTCCAGAAATCCCTGAGCCTATTTTATTAACCCGGATTTTTGCCAAGCTTACTTCTTTAGGGCGTATTCATCACGTTTCTACGGGCGTTGAATCCTCTTAATTTGGCAGAGGTATTGCAACAGTACCAGATGATAATTCGGTGGGAATATCAAGGTGTAAATTTCCCAAATCATCGATAACTGCTGCCAGTTTTATAACTTTCATTTTTTCAGCAGACCCTAGATAAATATTTTATGACTTGTTAATGATGTCTAAAATCGAGCGTGATCGCTTGGCGAAACTATGAGAGATATTACTTTCAACCCCACACCCGACGCAAATTAAACACAAAACCAGGTAACACCCCCTCACCTGACAACTCAGAGGGATTGTCCAACACTTCCACCTCTACACCTGGTCGATAAATTTCTACTTGTCGCTGCTGCGGATTGAGTAACCAAGCTAGCGTTGCACCATTCTCAATATATTCTCTCATCTTCTGTTGCAATGACTCCAATCGATCTGAGCTAGACCTTAACTCAACAACAAAATCGGGGCAAATATTAGCAAAAGTTCCTTTTTGTTCAGTCGTTAGCGCATCCCAGCGTGCTTGACTTACCCAAGAAGCATCGGGAGAACGAGTAGCACCATTGGGTAAAATGAACCCCGTAGAAGAATCAAAAGCTTCACCCAAATTTTCATTTTCTTCGTACCAGCGATCTAGTTGTCCAGTGAGACTGCGGTTACGCTTCCCAGTTTCCCAACCTGTTGGTGGGTTCACAATTAATTCTCCTTGTGCGGTTCTTTCCAGTTTCAAATCTCGGTTTACTGCCGCTAAAGCTGCAAACTGTGCTTGGGTAACACGCAACCCAATGGATGATGGTAACTCCATCGACAGGGTGGGATTCTCTGAATTGGTGACCATCTTGACCTCTTGTAAAATAGAGCTTAGAGAAAAGATGCTTACCCTATTTACTGAATATATTCTACCAGTCTATAAACTTCTAAGCGATCACTTTGTTGGCGTAAAACTATTAGGTAGTGTCATACTCCGTAGGAGTGGTCTAAGCGGAGAGCGTCGCGTCTAATTATGTTAATCATAATTCCTATTTACTTTACATTTCCCCGCTACTACCCTCTGTCAAATTCAACAAAGTCTACAGCATCTGTCGAGCTATTGTAACTATTGGATACGGTTAGTTATTTCCCCACCCCCAGTTTATAAATTGGCAACTAATAACATTCTTGCTTCAATTTCTTGCCAGGTGTTCGGAGAAATTTTCATCGATGCTTGCTTGCATCTAACCATGAGCATATTAATATAAAGATAATCTTCCAAAGTATTGGATTCTTCAGACGACAAAATAGTTAATTCTGGATTTAACTGCAAAGCATTCAACCAAGTTTGAGAAACACGGGAATTATATCCTTGATGAACTTTGTAAGATTCATGAACATTCGGAGCCTTTGCTTTCAAGGTTTCCAAACTCTCCATTAATGTCGTAAAATTGATGTAAGGAAATAAATCAAACTCTTCCAACTCTTGGGCGATCGCCTTATTGATGGCACGGGTAAAAGCGCGGGTTGGAGTTGCCGGACGAGTGGGAGTGCGATTATATTGTGCCATGCGGCTAAAATTAGGATTTATTGCCCGTGCTAAATCCGATATTCGACTCATTTCTAATACATTCGTCAAACTAGGGCTGAGGAGGGTTGCTATCTCAAATGCGCTATCTCTTGCAGTTGCCAGGAATAATGCTGTAGCACGTTTTGCAGCACTAGAGAACTCTGAAGCATTACCTGTGGTTGCTGCATTTACCCAACTCATTAAAGGTCTAATTTTCCTCGCATAAATTGAGTTTGATAGTTGATTCTGTGCAGCTTTTTCCATTATTAATAATAGCTCATCTGAACCACCGCGCATTAATCCCGCAATCAACAAAAATACTTCACGCCAACGTCTATCTAATAAATGCTCGTTGACCATTTTTGCAATTAAGGAATTGTCGATAATATATTGTGCTGTTAGATATTCCTGTAGAGTCAGATGACAGAAAGAAAATACATCCTCCGCACGCTCAACCAATACACCCTGCTGGATTGCTATCGCCTGTAAAATAGATGAGCAATCGATATGCTTGGGTGCATTCAAGTTACTTTCTAAAAAGTATCTAATCTTCTCTAAAATCTCATCCTCGGAAAAAAATAATTGGTCTACCTCATACCCTGTATAAGCAATTTCTGAAAGTAGCATTTCCTGCAATTCAGTTCGCAAACCTTTATAAATCTCCTCCCGCATAATCCGTTTTTCAGCAGCCCATTCTTCTAATAATACTCTTAGAGCTTTTTTGTAAAGTGCGCTGCGATTATTGGGGAAATGTTGGGAATGGTCGTAAACTAGACATAACATTGTTAATAACAAAGGAGTATTTGCTAATTCTTTGGCACCAGAATTGGTCGCTTCGTGTAAAATTTGCCAGCATTTTTGACCAGTTTCTAATTTTTTATCTTCTTCTGATTGAAACCAATTAAAAATAAATTGCTTGATTTGAATACTATCGAATTCCGCCATCGCTACATCGGTAAAACGATAAAAATTATTCATGTATGCGGCTGTACGACAGGAAATAATAAAACGATTTTGATGGTACTTGTCGCCAAAATTCTGAACCATCTCAATCGCATGACTGACTATTTTACTGGGAACCTCATCTAAACCATCGAATAATATTAGTAATTGTCCCGATTCTAATAAATTATTTAAAGCAGATTCCGCATCTGGAAAACCACAAATATCGAATTCATGAATCAACAATTCTTCCAAAGTGATATCCTTGGAATTTATTCTTTTCATTTCGATGAAAACAGGAATACATTCGTGCTTGTATTCACCCTTATTCCCCTTCAGCGCTTCCAAAGCAATCTTTCTTAAAAAAGTTGATTTGCCAACACCGGGTCCACCAAGTACCATCAAATATTGCTTCTCATTGGCAACAGCTAAACCATCTTGCCTTGGCGAATTTTGTGATTGAAAGCTGCGATTTTCGCGGTAAGCTTTTTCCAGATTTTCAATCGACTCGAAACGACGAATATCACTATTATTTAAAAACTGGACTGTTGTATAAATTGACTCTAAAGCCACTGGTTCGCGCATTCCCAGAACTTTTAAGATACCGTGACGATCTGTATAATTTTTTATATATTGCCGAGATGCTTCAAAAAACAACTGCTGAGTCTTCAAATCGACCATCTTCCCGATTTTTGCCATCCCTTTCCAGCCTTTTTCGATAAAAAGACCAGCTAGGCTTTCAGTTGCTTTTCCGATTAGAAGTTCGGTGACAATCATGGCAGCGTTCCTAAATAACTATGATTAAGTATAATTACGGGATACTCTCTGGCTGCTGCTGTTTCCGGATTATTGAAGCATGAGTATAATATTTTGCTTGCAAATAAAATAAATCATTAAAGCTGCGTTGAGTATAAAGCTGGCTTAGTAAGCATTTACAGCTTTTTAAGCGAATTATGTTTACATATTGACTACTGTATAAAAACTAAGCTTTCTGTATTGAACTTATCCTCTGCCTGAGTATGTTCTGTTAAGCGATGCCCTTTGTTCCACTTTCTTTGGTATCGCACCCAACCTCTCCCTAGTTCCCTGCTTGCTGCAATACTCAACCTCCTGGATAATTGGGAAATTACCTGTAGGTTGTGTCCAATACAATAGTTCGTAAATACTATATTTATCACTGGTGGACACCAACAACACTTCGACAAGCCAAGACGCAAGCTACAGTGACCACACGATTTTGCCATCCCTGATAAACCACGTCCCGCTCATCTTTCGGCTCAATAAACTGGTAAACCCTTTCTCGATTATCCCTACTCCCCATCCTGCCAACGTAGGTTAACTTCAACCCCAACTTACTCAGTAGTTTCTGGATAATAGCGATCGCACTCAACCCCTCGGAAACAGAAACTCCCAAATAGTCACGGATAAAATATCGATGCTTCACAGCCAAAGCCTTCAAATTCTGCAACTCCGCATCAGAACCGCGAAACATCACCCCTGGCGTGAGAAAATAACGGATATTAAATTCCTCCAGCAACAATACAGCAGGTAATAACTGCCCCCGGTTAAAATCAGGCTTCCAAACAGCACTCTCACCCGCTTCTATCTGCGATTTAGCCCTTTTAGAATCGCGCTCAATAAGCTGTTCCCGTCCAATGGTGAGAAAATAATGCAGCCGCAGTTGTGGATACCAGCTAGAGCACCAGTCCAGTAGAAGTAGTTGACAAGATACATAGTTTTTGCAGAGGCTAATTTATAGGAGAATAAGGAGAATAAGGTATGAGGAGTGCAAACTATGCGTCCATTAATATGGGAACCTCCAATCTCCCTGTCAAGCAAAGAAGAAAAAGTTGCGAAACGTATACGCAAAGCAAAGTTATTTGTATTTTTGCGGCAAATACGACACGAATTATTTGACCCAGACTTCCAAACGGAGTTAGCAAGGGTATTCAAGGACAGTAGTGTTGGTTTATCTCCAATACCACCAGCACAACTTGCACTTGCAGTAATTTTACAAGCATATACAGGGGTTTCAGATGACGAGGCAATAGAAGCGATTGAAATGGATAGGCGATGGCAGCTAGTTTTAGATTGTCTCGATTGTGAACAAGCTCCATTTGGCAAAGGGACACTAGTTAGATTTCGTGCGCTTTTGATGTCAAAGTCTCTTGACCAGAGGATTGTGGCGAAAACAGTTGAAATGGCACATTTTCATGAAGGTTACAATCCGAAGTCGTTAAAAGTAGCCTTAGATTCAAGCCCGTTATGGGGAGCGGCACGTGTGGAAGACACGTATAATTTGTTAGGTCATGCACTAAGGAAAGCATTATTCGTAATAGCTCAGAATTATGAACAGGACGATTCTGGTGTTACAGGCGTTACAGCGACTATCGGTGCAGAAATCATCACGGGAACGAGCCTGAAAGCTGCCTTAGATTTAGATTGGGATGACCCGGAAGCTCGTAATGTTGCACTATCTACAATATTGCAAACATTAGACTCAGTTGAGTCTTGGGTACAAACAAAAAACTGATTTGGAATGAAAAACAAGCACTCAAGTCAACAAGAGCATTGAAGATGCGAGGCAAATTGAATCACAAGATGTTGAGGAGAAATCTGATGGCTCCCCAAAGCTCCGTAAAGGTGTTGCTAAAGATAGACGCATTTCAATTGAGGATGAGGATATGCGTCATGGTCGTAAAAGTCGCAAGCCAAAAAATTGATGGTTACAAACGTCATATTTTCAAAGACTTAGAATTGCAAATGGTAAGAGCTGTTGGTGTTACCAGAGCAAACGAACCAGAAGCATCTGTAACTATGGCAATTGAGTTCGACTTAAATGCCCAGAACGTAACAACTCTTGACATCAAAGAGCTACATATTGACCGTGCATATTTAGCTAGTCATTGGGTTAAACAACGCACACCTGATATGACTATTATTTGCAAGGCAATGGAAAGTCCGCAACGGTAATTTTTTTGATAAAAAATGCCTTTTGTTCTGGATTGGGAAAATCTATTTCATTCGCTGTCCCAATGGAGTTAGTTTACCCTTTAATGAGGGGACTGTTGTCCCACTTCCCCAAACACGAATGTCAAACCTGTCCTTTACGCTCTCAATGTACAGAGAGTAAGCAAGGTCGCAGTATCTCTATTCACCCTGACGAGTCTCTACTTGTAGAGCTACGGGAACGTCAAACTACACAGAGTGGACGTGAGAAACTCCGCGAGCGCGTTAGTGTTGAGCATAGTTTTAGCTCATATTGGTCAGTGGCAAGGAGATAAAGCTCGCTACATTGGCTTACGCAAAAACCTTTTTGACCTTCGACGTATGGCTGTTGTTCATAATCTCCACGTTCTTGCTCGTATGTTTGAAACTAATAATAAAGAAATTTCTAATTTTAATAATTCATACTCTGCCTGATTTGTCAATATCTTCTACTGGACTGGTGCTCTAGGCTACCAGTTCAGTCCTCGGCTAGCAGATGTGGGAGAGGCTCGCTTTTGGCGTTTAGATTCGCTTGCAGATTATGGGGTTCTAAATGGAATAGCACGCCAAAAAGTCAATACCTCTTTTATTGAGAATTATTGGGATGACATGCTACGAGTTGCTGGGTCTTTGAAATTGGGAACGGTAAGCGCGTCAGAAATTATGCGAACTTTATACCGAGGTGACAAACCTTCTGTTTTGGGTCGAGCGATTGGAGAGTTGGGACGTATAGCCAAAACTTTGTACCTATTAAACTATGTCGATGATGAGGCGTACCGTCGTCGAATTTTGACTCAGCTAAATCGAGGTGAAGGACGACATGGGCTTGCCAGAGTTATATTTCATGGTCAAAAGGGTGAGTTGCGTCAACGTTACCGGGAGGGACAAGAAGACCAACTTTCGGCTTTGGGGTTAGTCGTAAATGCTTTGGTACTATGGAATACATATTATATGGATGCTGCACTTACCTCTATCGGTTTACAGCAAAGCATAAATCAAGAGGATATAGCGCGGCTATCGCCTTTGGGGCATTCCCACGTCAATATGTTAGGGCGTTATCAGTTTTCTTTACCTCTGGCAGTTATGCAGGGAGAAATGCGTCCATTACGCGATCCAAATGACCCAAATGAGCAGGAGGATTAAAACGCTTATGTAGCAGGCGTTTCAGCCTTAGCGTAAGTTTCTGTACGATTGCTCATTTCACCCCCTAAATAAATGTTGCTATTAAAATGAAATCACGTTTGTTTTACTACAACAAATATCAATAAACCAATTACCTAAATTTGGGAAAACTTCATGATTAGAATCGGTTAGCCGCTCAATCTGTTTTTCGATTTGAGCCATAGCTTTTTTTGTAAGCTTTACCCCATTCTCATAAGTTTCGTGTACTAGCTTAACGACTGGATGTTTCCCGTTCCATTTCATAGTGCTAGCAAAATTTAAAGCCGTTTCTAGTTCATCTAAAATACTCCCATTCCAATGATTTTCTAGTACTGCCCATGTCCTTTCTATTGGATTGTATTTACTATGATAGGGAGGATAATAAGCTAAACGTATATTTACTTGATGTTTGTGAGCAAACTCTACTATACGTTTCATAAATTGGGTACGCCGCGAACTATTCTGCGGACCATTATCTTGATTCAGAAGTAGTGTTTTAACTTCAGAAAAACGATGCTTTTCACAAGACCAAAAATCTTCTAGAATATCAACGATAAAATCACTTGTAACTTTCGATTCTGTAAAGTACAAAAATAACTCGTCAAGCTCTGGAAGAAATATTCCATAAGGAGTTACAGTTGTTTTCGGATTATAATCATGGTCTGATGCTTTCACCCCATCCCGGCTTTTACCCCCTCGGTCAAATGAGCCGATCTTAACACAGGCTTTTCCGTCCATGCTTAGACGTAAAACACTCTTATCTTCATCTGCATCTTTATTTACTACATCTAATTGCTCAAAGATTGCATCAGTTTGTGGGATTTTTTTTGAGGCTGAACTTTCTTTACCCTTCTGAGCTTATAACCTAAATTATTTAATTTGACTCGAATTGTTTCTGATGTATGTAACTTTTCATCACTATAACCAGACTTTTCGATTAATTGCTTTCTAACTTCGGCTGCACTGAGTCTAGTATATAGTCTTTGACTTTTAAAACTCGGATCGGTTTGACTATAGAAGTCAACTATTTTTTTGATATCTTCTAAAAGATTTGGCAGATGTTCTTCTGCTTTGTAACGTCCTTTGCCACTCATGTTATCAACACAAGTAATACCGCTTTTTAATTCTCTTGTTCCTTTGCGAATTGTGTCTCGATTCCATCCTAATTCTGATTGTGCAAGTCTTTGCCCTCCTAAACCTAAGCTTTGAACTGTCGAAGCCATAAATCTACGCTTTTCTGCACCTTTTAATTGAGATGCAGTTTCAATGAACAACTTTTTCAGAGAATCAGTTAATACTAT

Protein sequences of DBSCAN-SWA_2

>NC_019751|291354:360224|320450_320843_+|WP_015196027.1|DBSCAN-SWA
MKTTRFLTFLGTTSALLMGLSLIATTSQPAKADWWDVGKQIIEDNLNGIRGNTVGRIYDQTFIAELSSEEVGQYKQRWGGNYSAKISDWCNDTVYQAGWRNLAGNQIPFVNTTWREENGKVNCYVRHAAQ
>NC_019751|291354:360224|341372_341636_+|WP_015196041.1|DBSCAN-SWA
MKSRYQNFLCDNRYTTIPIPQFQAISPQLPERETIKHTLIGSTKAVTATIRLLDQLGYADMLDWSPLVPTDNPGQVMSILVRAIAIQ
>NC_019751|291354:360224|292731_295848_-|WP_015196009.1|DBSCAN-SWA
MRKIIDVLGIISIAVSPIVLGVAYAQTSVPSIARPVESTTEKNFPLNQPQEVTFELNEKLAETQNLNNPENSATEKEEQLRDWLLLTVLSGKGLSTQEISRSIHDISIIRYDFMRSMANAKLEYGATRSRHIGNGRLVALVPKNQSSEERKKDLAEIADYHRKDIGIKPKVIEVFEYDISANQQLAQITRRGEIDTAKIFSNEYGYYETTITNQDKLKDFLSKTDDITFTQVIDSGLVLGGRKIYRGKDSPKYQVLKVEDIAALYQARQDIDKKSNDFYESDFYKNWSKKTKNLSGDELENAKKPMREEARKNRIVDGSGFSLDWEYNYPGLEKALDEAIPLLKKIKIDGKAVINEQDIKKAKNGLSRKDAEDYFKLVDKIESVWVSEKDKIFKQGEIATEIQKEIKSYQEKEKKNQESINKQIEVYKIERENISNSALSPEEINSKIIELDIIIQELEAKLAEDNTLKKSSEKAEQKTNTRLNYEYKINNLLASKKNNGFQFARYDGDLIRGTEVGMTLFYTDLLMKIFDFNFEKATEETGIKGFRSSTQIPTSPIYKSDRQKEQFVRLWFDPNESGYSSNKVDMNIVFSRHATHIKALASNDSKSKNEVTAPPDTTAFINWWNNHYEEVARYEPQFERLNQIMKWNLIINILSCFQDTSCQKSENFLQSDPLDFLKSIEVNRDNDSFLNWAKKQGKNLKFKKWSQITFIPEGYNDRGKKTDKLKFLDSEKIDERYGKSYPSLYGGVSLGNKMDFADSISLPKDNPLDDIALRSNINPQKTLAYKQEVKPQKGELALKTSEETNIIIKPLGQKTSSIITEPKAGTKIRNLDAELNQFSKFKAVPTQTSNNGLKLTTRLEDAKGISAEFGELNITKTKNGFKTAFESLDIDTGYSLASDLSKHNGDIPSFIASKSDVFPFRYSPSQPNDIYVKLPNSNKSLKLSEGSGGGNGLPPSKSMMTVAEPGKNSRIINVDIVDEAQIPGNAQRFGKGVDFPEEGFNPSQKAQKLSEDPMAFVLSRKLDLQSRIKNMVLRYLLC
>NC_019751|291354:360224|345625_346075_+|WP_015196044.1|DBSCAN-SWA
MEAIIFVGIQASGKSTFYRENFLNTHIRLNLDMLKTRHREQIFIQACIEGKQPFVVDNTNPTPAERSRYIVPAKANHFQIKAYYFDSPLEECKQRNNQRQGKEIIPLIGLLGTHKKLTFPTWEEGFDAIYSVNLDINNSFQIEEWKNEI
>NC_019751|291354:360224|307408_308317_-|WP_015196017.1|protease|DBSCAN-SWA
MKTSHIKSIRKIIFTTLGFSSSILLSLNTPGFAQALITLPDLSITNSSISTSQVKPKKTNLQWVYSVAEKVIRANGLDEHPWRFQVSDEYNINAYAGELNKIVIYKGLLDQIHGDDAALAFIIAHELAHHTQRHSAQQEEAEARLKDKLLKEAEAEFTSWIVAEKQKSQKPISIAEKDVIKQRILIQKKQEFDQAIQALSRQHEFQADAVGYTYMGKAGYDPNGGLRVFNLFHRLPSDYTENSTHPTTEQRIDALNQVMNKYPWRTLWADGNERLKVNSQPLKFDVIENGISLRINSKFLSE
>NC_019751|291354:360224|358986_360224_-|WP_085953333.1|transposase|DBSCAN-SWA
MVLTDSLKKLFIETASQLKGAEKRRFMASTVQSLGLGGQRLAQSELGWNRDTIRKGTRELKSGITCVDNMSGKGRYKAEEHLPNLLEDIKKIVDFYSQTDPSFKSQRLYTRLSAAEVRKQLIEKSGYSDEKLHTSETIRVKLNNLGYKLRRVKKVQPQKKFPQTDAIFEQLDVVNKDADEDKSVLRLSMDGKACVKIGSFDRGGKSRDGVKASDHDYNPKTTVTPYGIFLPELDELFLYFTESKVTSDFIVDILEDFWSCEKHRFSEVKTLLLNQDNGPQNSSRRTQFMKRIVEFAHKHQVNIRLAYYPPYHSKYNPIERTWAVLENHWNGSILDELETALNFASTMKWNGKHPVVKLVHETYENGVKLTKKAMAQIEKQIERLTDSNHEVFPNLGNWFIDICCSKTNVISF
>NC_019751|291354:360224|333002_333431_+|WP_015196033.1|DBSCAN-SWA
MNWQPYNLDQEAQRLVLAFRNKEGVIGQSHKMRVTVAYGLERFWGEHLRLLGKNDAKEREKGKYWQSVWKEFVRIMKRTGVELPSDEISDRNTEQIEEVAKKLWSLSLDDQKICLSVLTQFCDSLVWWTQRYKKAGDREEEV
>NC_019751|291354:360224|335224_336832_+|WP_015196035.1|DBSCAN-SWA
MAIWIITTGNSDVRIKKENNWNTIFHTIRDNLECTDFASPIPINPNAIEEGYTLPARVLGVAYSQIIEQEPKYFDELEFPLIETFCQKLKSEKKLEKKSHKLEQIFVLTTDQNNLFPNKWDRINEKCPYWQDTIELQTLLEKYLKTQFDIPIEFISLCPNSDEGLDYWDATLKLVETEFSQKFAKLQDKIVYVSHQAGTPAISAAVQFASLGIFGKVEFLVSNQYYDASYNHQAKAKIIDSSEYWRGLQIQKAKPLIRNGFPSTALKLLDGIDRIDKNIILQLEQMVDFFNLKSQSQNTNPDSIKEDFGIPNATQRIVDGLDLIGFFFKQNNYLPGISLLAAAQETFLKVAIKSEIQKNTANYCGIPVAELVKWTTKGLISPNNDELRNILKLPNSQNIDKVRNDIFDLLKFPYSKHNDRFYLYSIKQDLEFSRTGMLEWLLILAPNFREWAHLRQSNLRNQVIHNLRGIEEEEVIAYLLGLRDYQPIPNNITTAMDAYIQKVKQPFMQAIVLLKLPCEKGKLQERLNAIADSLI
>NC_019751|291354:360224|338483_338750_+|WP_015196036.1|DBSCAN-SWA
MNIINITFTHPFAKAPKHVFGQQVTIKSNCDRKKWAKGQITGLRLDYNSPNTWNYTVVFDYPQGFCEEFTEEDLAAVDELVCSQLLFK
>NC_019751|291354:360224|346886_349463_+|WP_015196046.1|DBSCAN-SWA
MKITIPELSLVILIGASGSGKSTFARNYFQQFEVISSDFCRGLVSDDENNQASSKDAFELLHYITAKRLATGKLTVIDATNVQPEDRKEYIKLAREYHFLSVAIALNVPEEVCHERNAQRSDRQFGSHVVRRHTQALRRSLRGLEREGFRYVHVLNSLEDINNLEIERQPLWNNRKYEKGPFDIIGDIHGCCDELEGLLQKLGYLKKPSIQSDKFWNFPLYHHPEGRKAVFLGDLVDRGNRILDTVKLVYNMVQAGTGICVPGNHEHKLLRKLRGKNVRVNHGLEQTLAEIDSIPEDIRETSIKELREFFDSLVSHYVLDGGNLVVAHAGMKKEMQGRGSGAVREFALYGETTGEIDEFGLPVRFNWASEYRGDAMVVYGHTPVPEAEWLNNTIDIDTGCVFGGKLTALRYPEKELISVDAAKVYCEPVKPLGIASNRTAQQEIDDVLHIEDVLGKRIINTRLQNNITIREENSIAALEVMSRFAANPKWLIYLPPTMSPVETSQLPGYLERPEQAFTYYQNQGITEVVCEEKHMGSRAVVVVCRDETAANRRFGVINEGIGIIYTRTGRKFFNDETLETELLTRLNTTLTDSNFWEIFNTDWVCLDCELLPWTAKAQGLLTKQYAPVGMSSRLSLGNAIALLEKAQNRGVDISSQLDSYKQRAEMANLYVDAYRRYCWNVGDISDIKLAPFHILASEGAVHTDKTHTWHMEEIAKIAKTNPELLLATNYQVIDLTDVNSKNRGITWWEEMTATGGEGMVFKPMEYIVRGNKGIIQPAIKCRGKEYLRIIYGAEYDSPENCERLRHRGLSHKRSLAMREFALGVEALSRFVAKKPLRQVHECVFGVLALESEPVDPRL
>NC_019751|291354:360224|350295_350550_-|WP_015196048.1|DBSCAN-SWA
MTLIKKSEQQLLLKIKKIEDEEQNIQPDAKDIPEVREEQKHLIIENTESNYIPARDNPIVQSIGNSGWQISDIWRDIRVDNFSD
>NC_019751|291354:360224|308554_309154_-|WP_015196018.1|DBSCAN-SWA
MKSWKLSVATVVLVASVCIPKAEAKNLSNTQANQVKQTFSVLANNSQVIKEPSLIAINDTYRGPNQDFEIQMPGSVQENEERKLMSWSDTTQTVYVIIHKDMPVDVSYLSVEEVEQVLQTSMREEMASTGKIVRSTNLEIDGYPGLELLVQHTDGTTGQYRGFIVKGRMYVMGAATQGELTTEAVNFFDSFGVYPERVR
>NC_019751|291354:360224|333427_335047_+|WP_015196034.1|DBSCAN-SWA
MTNYREIPLMFQAQIKGRGQIQYIAQPEKAYRWVDEWEEGVGNDVSNFSNRVSTKEYKITWRFISNSGQDDDVIRPVIASGGFPYYPGASMKGAFLRSCTPEQAMHYCGGIASKADSTTKPGILRFHGGYPKDATWKDKELVDVVHPQADWQLKDSSSHSAFIQISLHEPTLVFGISSNIKIESSEWDTIWSIWEKALERGIGSRVSAGYGQPVKHPETKLLTVGLTGQGLASQLINKTGEFRPNMFKAALRGHTLRLFAGITDENSAEALTRELWGGFAGKDGAVVGDLGIVFNPLELEMDGYRYRGNSIPTYELNNGILHILSMRSVSEEYKTELRSLAIKLIQFSLLLGGFGKSWRRIDHRIFFPDYLKNNQKPMIGCHWEFHQGAEKLYIPTNRLENISKFFTTLDEKIHQWIIANNKKTSNNLSQWREVWHPQKVQVWARVAEDEDDSSAVHWFHGEYKEGGTIKGSTLTGQIGQIGRIWHRMYPRYSKLKDGTMRRMGDEYIELLTIFPDTSNTTTQFIDFLGKSYFKRIYPS
>NC_019751|291354:360224|353424_355551_-|WP_015196051.1|DBSCAN-SWA
MIVTELLIGKATESLAGLFIEKGWKGMAKIGKMVDLKTQQLFFEASRQYIKNYTDRHGILKVLGMREPVALESIYTTVQFLNNSDIRRFESIENLEKAYRENRSFQSQNSPRQDGLAVANEKQYLMVLGGPGVGKSTFLRKIALEALKGNKGEYKHECIPVFIEMKRINSKDITLEELLIHEFDICGFPDAESALNNLLESGQLLILFDGLDEVPSKIVSHAIEMVQNFGDKYHQNRFIISCRTAAYMNNFYRFTDVAMAEFDSIQIKQFIFNWFQSEEDKKLETGQKCWQILHEATNSGAKELANTPLLLTMLCLVYDHSQHFPNNRSALYKKALRVLLEEWAAEKRIMREEIYKGLRTELQEMLLSEIAYTGYEVDQLFFSEDEILEKIRYFLESNLNAPKHIDCSSILQAIAIQQGVLVERAEDVFSFCHLTLQEYLTAQYIIDNSLIAKMVNEHLLDRRWREVFLLIAGLMRGGSDELLLIMEKAAQNQLSNSIYARKIRPLMSWVNAATTGNASEFSSAAKRATALFLATARDSAFEIATLLSPSLTNVLEMSRISDLARAINPNFSRMAQYNRTPTRPATPTRAFTRAINKAIAQELEEFDLFPYINFTTLMESLETLKAKAPNVHESYKVHQGYNSRVSQTWLNALQLNPELTILSSEESNTLEDYLYINMLMVRCKQASMKISPNTWQEIEARMLLVANL
>NC_019751|291354:360224|303797_303959_+|WP_015196014.1|DBSCAN-SWA
MSTPAAGIANHEIVETEEGFILPFLAPIYLSLRRVSFYAFSVKWFFLEKYPIG
>NC_019751|291354:360224|298101_299709_-|WP_051036588.1|DBSCAN-SWA
MVSVISQILDYAAYYLGTLVLNFHKGIGRTTNPSYLDQPFLGKAIAKRLTYFTVMYDGSNAWIIDGGAIHGIISTQGNQNTRLAIFPIDLEDISQLENAIAVAEVTEVLPQSSRINISGEREELNRELIYKAVITYLPVAFLQVYIEGDTSGVSFAHQAIQTASFGENASLYICGVDNSYEADFYLKAINDEYQIIRASDNYQVISPISGFTIESALQAIYFLEHIARWRNIASITSPANSLIPANAVKVKFYLQDVETYEVQDYQLSLTYKVQDDTLKPPAIQVKLINTSDITLYSVLLNLTELFAITAIPFAGGCTGIWLEPGEETWVLEGKYIPISIPINFQRRGVREYKDILKLIVSTSEFDANLLAQDNIENLNRRSSRSNNIGEGNCLIQQIQMRAIAPCPDETEQSTILDDWVTNEILVVTTIPRNINLQLPEHQILNQSSKSLPANNMSTDSRGFKYSQLMVAISLIFILMLVGTVSWVIIQRGKQDKQKAFHHHTLISKLAVGKTKNVNLIFIHEAFIKIIYSTCG
>NC_019751|291354:360224|301008_301866_-|WP_083866289.1|DBSCAN-SWA
MDRNIYVLAVGINNYKSSKIPSLKGCVNDVTALDEFLKKHLVTNEDKLHLKRLIDVQATRQAIIDGFREHLCQATSNDVALFYFSGHGSQENASEEFWHLEPDHLNETLVCWDSRTDGIWDLADKELAKLIAEVSQNHPHFVVILDCCHSGGGTRAENDVSLNAYTGIRTVNTESKERPLSSFIFSDEEINSLLATSNSSNVANRFSLSRGEYILLAACRDNELAREHQSQKRGIFSYFLLDSLQRNSNLTYRDLLKRSNILVRSIYTNQSPQVEATNPVLPIPL
>NC_019751|291354:360224|309454_313111_-|WP_068972685.1|DBSCAN-SWA
MSEIIETITQLNREVVKLAEAGDFEASISIAKEAVKLGEKNIDEHPAFADSLNNLAELYRMQGYFVEAKPLYIKILNLRKRLLGDSHPDVAQSLNNLAAFYVSQGLFIEAENYFLAALDIWKIYLGDEHPEIATNLNNIAEVYREQGRFQESEKIHLQALNMRKRLFGDFHADIAQSLDNLAVIYENQARYSEAETTHLEALEIRREIFGDENWQIAASLNNLAALYNSQGRFVEAAENYSQALELCKNCLGNEEHPYIAITLNNLANTYKNQGHYAEAEKTHFQALSMRKNIFGDEHLEVAQSLSNLGDIYLIQGRYLDAEEVYLQADSIKKDLLNPEHPDIALSLHNLGVLYTYQGRYQQAEAKYLEALSLHEQSLGKNHPIVADNLNHLGSLYQEQGLFSDAEQKYLAALAIRKNIFGEEHPDIADSYNKIAEIYRLQGRYSQAEGLYLEAYKLNKKLLGEIHPDVAAILSNLGVLYDAQFKYSQAEPLFTEALLIVRTKFGDNHPQVASVLNNLAAIYGSMRRYLEAEEIHLQVLEIRKSIFGSEHPDIANTLNNLAEIYLAQGKYAEAEKYYSSALSVRIKFLGENHPDVALSLNNLATLYAATKRPDNALSHRIQASTIHDKLISNVFAFSSENDRLAFIDKIRGNFDLFLSLIYQYFPNSETATQEAFDFILKRKGLTAASLAAQSQAFYNDRYPQLTGKFRQLSELNTQLVRLTSFANQTQNIANYQSNLTQLRSQYDNLQKQIASQVPEIQLSTQIPNRHAVASALPTKSVLIEFVLFDVFDFQAIQANGETQWKSPHYLAFILPAGQADGVQMVDLGEADTIHNLINLFRLEASDGGEETLGWAKVKTTPQLQIKQYNPAAAVELSQIILSPILDVLTDCDQIIFAPDGNLNLVPLQILPIYPSERSFLMDKYTVSYLGVGRDIIHSQHQPTTIGDTPIIIADPDFDLAMANNNLPNLENPTKQELLDTLDIKLDIKVLPPAHGTRLLGASVAKKLKNARLYTGAKALSTCLTNSKCPSIMLIATHGLFIPDSRQSNPMMRSAVAFAGANTALLGGNLPKQAGNGFIFAQDIAGLDLRANELTVLSACDTARGDIKIGEGVFGLRRAFASSGTKILVMSLWEVPGRATALLMEQFFEHYQNGVAAVEALQNAQNYIRNITVEELRKSDLGMEILTELSQVRGLEISTNGNKKPLEHPFYWGAWICQGL
>NC_019751|291354:360224|319267_319537_+|WP_015196024.1|DBSCAN-SWA
MQIQCVRFCLIFSPKAEKQLDDLPNKDRKQYDKAFKCFIQNSPAYRSLRTHRYCSKDGDIWSSSASMAKRFYWRYLEGDIIEITHIDSH
>NC_019751|291354:360224|295916_297932_-|WP_015196010.1|DBSCAN-SWA
MVALLCRPQERVFPSISANLYSLSCDRADLTTEQQAACKLLNLIEQKYSGSRLDVLGRFGHLLRQHQQAIASELESKWQRADFFWREVQVELKNLVAEREVWQDLALTVAGGHSEAIIMNNPVKLRQLLLHELFIDTHCAFYNGLIQNVTKPSWNERAFVHIDYIQQLLELSVIDGEEVKNLLAEAWQTRINACKEAKKWQLAIKYCQQRLKYLPHNIDFQDELAEIHYLAALEHVTNENVQIYHASNIKYLKKGINQLEKYLKKYPYSLKNFEMLSFLYRLRAVNLARNEQLAEALVCGEKAITYNPYSEQAVATRNELIDIMEQLQQQMNQLLAPVENNSRSFSAESAVVFTVGLLINPLGTLISSANNNTSQLNEKGEKLLAEAKQGFIPINAYIDSEEKKETENAFFAAQAIYLWHQIGLLEPSDGWLKFAEEKGGKNAIESTGNLINTALQLQEAVHSLLQEVPQAKEAIQPAWKKLVETKPDLADLDSALICDYLKHILFGEEREHNIFVATSTGNVQATQVLTPVSTKGKFSMEPFIPWVLSSQDKRIKIQAVLAGILILASGFVMMREKTTFVVRKTAFQQILTASQVQNDQAVLKASKSFFQNGSIFNKDERATEIKELFTESLLRWFPQQSSGEKLTLEQEEYLQLHKQLQKDFPDNQENQ
>NC_019751|291354:360224|322570_323808_-|WP_085953333.1|transposase|DBSCAN-SWA
MVLTDSLKKLFIETASQLKGAEKRRFMASTVQSLGLGGQRLAQSELGWNRDTIRKGTRELKSGITCVDNMSGKGRYKAEEHLPNLLEDIKKIVDFYSQTDPSFKSQRLYTRLSAAEVRKQLIEKSGYSDEKLHTSETIRVKLNNLGYKLRRVKKVQPQKKFPQTDAIFEQLDVVNKDADEDKSVLRLSMDGKACVKIGSFDRGGKSRDGVKASDHDYNPKTTVTPYGIFLPELDELFLYFTESKVTSDFIVDILEDFWSCEKHRFSEVKTLLLNQDNGPQNSSRRTQFMKRIVEFAHKHQVNIRLAYYPPYHSKYNPIERTWAVLENHWNGSILDELETALNFASTMKWNGKHPVVKLVHETYENGVKLTKKAMAQIEKQIERLTDSNHEVFPNLGNWFIDICCSKTNVISF
>NC_019751|291354:360224|349673_350186_-|WP_015196047.1|DBSCAN-SWA
MLDLTKIQAIAQSYSPQELFAALVWQRQFNNFYGEQVITDLSQHPELWVSFLFTKPIFAPDENGLSFGGVIDTLIAMANYRPMPEDSIIHFVNYPADTLYILTENQDTKVSKLVDFGKKWQADSVDVTDGADENYSFRLKRQLRYRFEGALWGEDKQRDRDAVVISYWWD
>NC_019751|291354:360224|329577_331143_+|WP_015196031.1|DBSCAN-SWA
MPKYTAITFAPVQGFIEKSRKLRDLYGSSQILSYLSQELLNEAGKTTEVVSPAIIKMQKGMPNRILLKGDFTEKQARDTLSSAWKRILFECRSWIGTKLPEKSYGTYHWEREWQNWGNYAWEVFCGSGDTISAAMEDLETKKLSRDWIGVNWIGESSSLTGTDAIAFPGLGAESRNPNNRKWSAEKEEIKTFYRRLACVLEGISLDKEPEGKYIALEEKLSIPELVKRLVTHEDIATSLGISPLGNSFSDIYRRPEKITETEKGRCTGWFMGDGDKVGDYLKDLAQKSDAEVKLFSQAMREWGRDFARDFPKEFGRVVYAGGDDFLGAIYSDKDKPKIEPEQVYQWLLELPNKWREHKQPINVSVGFIWAASSVPQRDILQHCREAEKVAKSLGRNRVTIRILFNSGQYVEWTCPWNYLNILDKYKDLDGNSNWSHIYTDLAQLEARNAFNIDKRTFNRKFALDFFDIYFPGEGEKLSKDNNLLKNIVGYTDDDEEYERVEKTIDWMRSLIKVGFQLCSNT
>NC_019751|291354:360224|339676_340066_+|WP_015196039.1|DBSCAN-SWA
MATRKSSTTTFNAIDDSILGDYAVNNYSERVYSKVYYSIRELCGLVAKRSLKEAFDWNNFKERFTSDFGKVEENRYSLEQLLEYANRKFGKTLEDLIVQNQISWQRRQEYTERSNMSYQSKMIEDSTCY
>NC_019751|291354:360224|306437_306971_-|WP_015196016.1|DBSCAN-SWA
MNTIWEKQLPSKTNEEFAEKITNFFRKLNQLDFRAISKKLTSNTENFQWTEEETKSAIHLYKMFLCLHFLFPNTELVPTVEIDRVWHTHILLNTAKYIEDCQELYGYILHHYSPADDDLEISHKFQKTAFDLTKHLFLEIFGIDICHNVAYHQGRCLILPQHFPQLQRSACLTIPKS
>NC_019751|291354:360224|291354_292575_-|WP_144051088.1|transposase|DBSCAN-SWA
MKVLTELLDLKDIKVTSQRIYNGIGIILQTESTKSYSICPHCGTKSEKLHQNHSHIIKDLPFSEKPVFLEVNRRQFKCYQCQKPFSEELYYAKKKRTYTNRLAQKIIQDVLESDIHSVASKGIVTTEEIERMLKDASEELCDSKPSNLKRLGIDEIALVKGKGDYCAVLVDLDASKLLAILNGRTQDKIKEALSGWGLEVLQQIEEVSIDLWQGYKNLVMELMPNAQVVADRFHVMTQINKELDTQRKRERRSIEEQIKETKSESEKAEYEIILAGLKNSKYSLLKNEDNLTDEQVVKLREVKRVSPVLKEMHDFKEKIRKIFNLTDHWYTGVFKLGMWLSKAKKYFPRSNNTIIRWFDEIIAYFDNGTTSGTVEGINNKLKLIKRSGYGFRNFQNFKIRCLLNWT
>NC_019751|291354:360224|321419_321713_+|WP_015196028.1|DBSCAN-SWA
MNKSINRFLLVGGLITVSSVTVATLPINPPAQAGWAPWVQVYVTDYSEGNGRDQGENVRVCQNKAKESGRPDRIKRWWFNSTFRDGKCWTRVPIWEG
>NC_019751|291354:360224|350750_350897_-|WP_158333120.1|DBSCAN-SWA
MAKVLTVDVVVVVNPSIPDTPQTKPYDFSDLAGRLNWQGDSVAETRYL
>NC_019751|291354:360224|299635_300853_-|WP_015196011.1|transposase|DBSCAN-SWA
MKFSVEQILNLPGIKVLNCQDIEGLGLIIEIQVDSKSSKCPRCGKASHSIHQHHWRNIKDLPWSNQQVILRIDRRQFRCKNCQKLFSEDLDFVDKQRGYTKRFAIEIVKQVLDSNIRSVAERNDLSESEIQSMLDSLESDISFETSEIKRLGIDEISLIKGQGNYLGVLVDLDRRKPIDIVESRRQSEMTQALQSMGNEVLEQIEEVSIDLWKPYKSLVKELMPNAEVTIDRFHVMKQVNDELDAARKQQKKEANSLKNKLDRDRILAGLLKSKYSLLKNEDSLNETQKEKLKAVQNVSPTLSKMHELKEKFRNIFNTAESWGDGVLKLLDWMYDSSLYFPKTIRTIFRWFGDIVGYFEQRTTSGTVEGINNKLKLVKRLGYGFRNFANFRLRCLLSWHFSVKFP
>NC_019751|291354:360224|319633_319933_+|WP_015196025.1|DBSCAN-SWA
MRKPKSLGERELHLIRVYSNWNFGMTPIEFYTKWEVSYEQIALICDRSDSTVRRWFKQGDNRRYPNRNDLLNLALIDFLLEHFEEIPEHLRRLLCAENF
>NC_019751|291354:360224|346064_346844_+|WP_015196045.1|tRNA|DBSCAN-SWA
MKFDELDTRMRVFETAHDHYVLPGLYIVARLDGRSFTRLTKEVHQFKAPFDEKFRDMMLDTVEHLMNCGIDIIYGYSQSDEISLLFAHDENTFSRKERKLNSILAGEASAKLSLVLGDVACFDCRISQLPNITEVVNYFRWRNEDAHRNALNAHCYWSLRGDGKTARQATSMMSGLSVAEKNELLFQHGINFNDLPKWQKRGTGLYWEEYEKDGFNPQTGLSVKTIRRRIKRDLELPMKEEYSEFIRTFLSCILSVTLV
>NC_019751|291354:360224|314349_316356_+|WP_015196021.1|DBSCAN-SWA
MFTLEHLNYAWLQVRAGSKSAGVDGISIGFFESMATEQLRNLVSQLQYGTYTASPAKGFYVPKKNGGKRLIGIPTVRDRIIQRLLLDELYFPLEDTFVDCSYAYRPGRNIQQAVQHLYRYYQYQPKWIIKADIVEFFDNICLALLLNALEKLRLEPNILQLIEQQIKSGIIINGQYQNAGKGLLQGGTLSGALANLYLTDFDQKCLNQGINLVRYGDDFVIACSNFAEANRVLDKITGWLGGVYLTLKAEKTEIFSPDDEFTFLGYRFAKGEVFAPPPPEPTQQGEWVINDSGTPYFRRKPKPEKPVSRPPKACSIDKPVNFPRAAISHYWQDFMSTLYVTDQGAYLSMKNQQFQVFYQGELKIKIPVVRVSSIVMFGCCNVSHGAVSMALIRRIPIMYLSQKGRYFGHTAVQGNAKVEYLMKQVICCQNPVFTRQQAETIVAAKLHNSRILLMRLNRRRETEIATQAIDFIEILIDSLPKAESMDALRGYEGKAATIYFQALGSLFTGFFAFDKRTKRPPTDPINSLMSLGYTLLSQQVFSFVQSVGLHTHFGNLHVPRDNHPALVSDLMEEFRAQIVDSFVSYIVNKKILTPEDFTSPDERGGVYLQASALKKYLKHWEEKLQSETTHPNTGYKVAYRRCIELQVREYVACLVGEVEVYRPMTWKM
>NC_019751|291354:360224|329011_329272_-|WP_041738925.1|DBSCAN-SWA
MYLNFWRDRISLLYYISESDRTCKYLSSGTPRVGVSYHDISRKISKSTLFLANRSGVLQVIGFWELKPLSVKAFSYFSLKGGLPNF
>NC_019751|291354:360224|341032_341302_+|WP_015196040.1|DBSCAN-SWA
MAEVLSEPQFQILTHQYTGEKTGRIYFPALFLAEFHTSVTQWLQQQEIIFEERDLKQYGDASFRLYFKTSDELERVYFQLITMTSTACN
>NC_019751|291354:360224|322012_322243_+|WP_144051089.1|DBSCAN-SWA
MLKRGVCAVIGVNTGECASERQNSPSPNYSSPNYPQYPEQPLNNSNQADEYPQYMPPNPEVPYGYPQYTSPNPEEQ
>NC_019751|291354:360224|344174_345563_+|WP_015196043.1|DBSCAN-SWA
MLLTISTTNQPATDLGYLLHKHPNRCQSFPLSFGKAHIFYPEASETLCTAALLLDINPIKLVRGRGTTLEHYVTDRPYVASSFLSVAMSQVFSTAMGGRCKDKPELVNTPIPLTAKLSVVPCWGGESILRELFEPLGYTVIAENHQLDEKFPEWGSSKYYTVELTNTIPLSELLSHLYVLIPVLDDEKHYWVGEDEVEKLLRHGEGWLNTHPAKEKITRRYLKYRGNLTRQALAQLAEDDNLDPDATEIEQTEAEIAIEKPLSLNKQRMLTVIDALKANNVKQIIDMGCGEGTLLRYLLKELCFDKITGVDVSYRALEIAKERIDRLHLPRNQWDKLQIFQSALTYQDKRFQNYDAVTLVEVIEHLDLPRLSALERVIFEFAHPKLVVVTTPNIEYNIKFENLPAGKLRHKDHRFEWTRAEFESWANLVAEKFDYTVSLKPIGDVDIEVGSPTQMALFKAAN
>NC_019751|291354:360224|339270_339516_+|WP_015196038.1|DBSCAN-SWA
MLQAISSGQTFVTNLEQFMTKADKFIKIYYAGISEESKVREIVQELQNLLSDTDLQQLEIDYQHYCEIKDLMSDCDDSAWF
>NC_019751|291354:360224|313459_314212_-|WP_015196020.1|DBSCAN-SWA
MSKRSLVASGAGIKLAKQALERKSLTQKALTVEVGLSWATVNNFFNQKPIDRINFEEICTFLDLEWHDIVAPFAEKEEVVQQTPLEKIWQQLTALGSPTEQMGLVLVKEETLGWGKKIGSYYEKSVRLGNYIQFEINLQTPGYLLLIQKDTCGQIWCFCPSPFAPQPQLENGKTSLPQMGSPMTAFPVEGKPGKEQILAIISPSIPNLQWLLQDSDEVLELTESHLMELISYVNKNDGNQILYTEYQILK
>NC_019751|291354:360224|301960_302929_-|WP_015196012.1|DBSCAN-SWA
MDANELIFTIPIDGKMFKIAEKFSQQEKNKQKSRTVYLNTLAILAVDFYCKCIGIKTEPSKSHGLDKIMSSLMNTASLFIKDKGLIECRPVLPKEELCEIPPEVLSERIGYMVVEIDEDNRQAKILGFAKSVENEKLSLTKLNSLHDFLLYLHKLEAVSVMEKSTNKVDIVDVAVSQLNTGIVKLSKWFEGLLDGGWEAELAVAKDLAISPVDETEKRESGAAKFIHLQHPSEPVLLILRQTQVNQDEVEIVLRLYPASESIFLLDGIKMTLLDEEDKQIPQLKKQSKANNWLQLRFKGNVGDKFGLKISLGEDSILEKFII
>NC_019751|291354:360224|317685_318726_+|WP_015196022.1|DBSCAN-SWA
MSTIYITEPDASFKLQNKYLKLLQQDKQRFFIRISNISQFAIFGNIKLPKDVMQIVRLNQIPAIYFTHTGEYVGRLENPSTVQAKYLNYQRQRLHDREFNRATAESIVWAKLHNQQTFLQNWTRYCTDYTTQRASDYLTLLMDNLSLAPCVEELHQYIEEADKVYYCAVASILSLYSSNPHTTAKQINRFLNLGNQLLHQYIYNHLKTAGLHPDYSILHRDTHHELPLAWDFSAEFRAPIVDDLVLNFVRNLAKNNGNGNGNGKKPYTHLQRFLQHWEGKLKTFVLHPSAGEVSYRQCIDLQVKEYIASLLGDVEYYRPLALKFHPEQTNFINMLETQKPILTLVK
>NC_019751|291354:360224|341797_344047_+|WP_015196042.1|DBSCAN-SWA
MSSAYQANQPSSNAAPNQESITGVVERLTFHSEESGYTVARLQRPRVSELTTITGSFAGIQPGQTLELNGFWHEHPQYGSQFQVVNYKETKPATITGIEKYLGSGLIKGVGPVTAKRIVAHFGVETLDIIENQIDRLHEVNGIAKKRIAMIQKAWNEQKAIKEVMIFLQTHGVSTVYAVKIYKNYGDKSIGIVTNNPYQLATDIYGIGFLTADKIARNLGVPEDSEFRYRAGITHILNEASEDGHCYLPQPELIEKVSQCLKTDDHQPNEDAIAQIIKNMSLADELIREISPDKTLLCYNPAFFNTENNLALLIAQRLRSPINPDMQRVRTWLARFTKSRKVELSPQQQEAVEMAAYSPISILTGGPGTGKTFSVRTIVELWKAMGKSIALAAPTGRAAQRLTEMTGLEAKTVHRLLEFDPKNMGFKRDMKNPLPQKAIIIDEASMLDLFLAYSLIKAISEDSQILVVGDNDQLASVGPGKVLADLMNSGKVPVVRLTQIFRQAQTSAIIRSAHQINLGQYPNIEPISETPQSDCLWHGGGQQPEHGVQAISELITDFIPSLGFNPAIDVQVLSPMTRGLVGTRNLNNVLQQLINPPSPQKLEVTRGGTVFRVGDRVIQLTNDYNREVFNGDVGFITNIDTEEQEVIVQYQDRDVTYDYADLNELALAWSVTIHKSQGSEYRVAIMPLYTQHYMMLSRNLIYTGLTRAKELAIIVGSKKAIGMAVRSVNQKERYTQLRERLAQISTISS
>NC_019751|291354:360224|318737_319016_+|WP_015196023.1|DBSCAN-SWA
MFYLVCYDIVSDTRRNKVSKLLESYGLRVQKSVFECVLDEKQYESISKLLMRLLNRREDQVRFYPMSAHNRCKVAVVGTQPEFSVDDAAFIV
>NC_019751|291354:360224|316385_316526_+|WP_158333119.1|DBSCAN-SWA
MAETLILSFYPTNRYPGKGLMLLEYGLITKNYQLFRKNFTPHKKWR
>NC_019751|291354:360224|325819_327913_-|WP_015196030.1|DBSCAN-SWA
MSALNICHFLIGVPGSGKSTFAAALAKLGNNVIISTDEIRTTLYGDAAIQGNWNEIENQALLLIQQAQTSKKSVIYDATNFKRAFRMDFLMKIKEDGETLPLRWIAWYLKTPIETCIKWNQNRNRQVPQPIIETMSKLLANFPPLIAEGFATIEEIDVTKFPTDTAAFTAQIEKRINSLKRRITNRNNRTQHDGIIFHRYSRLLDFDRLMHLISLVIKYPGIGNLHTTNPKLLENILGEIPETTSNIDEITKIMAKLHGGIYGNPSEIIADLQWLEENGVIAGNKEQENNSLSLPSPLSFHCPHPTHSYSDTEPFQRLIGTISFILHNPFLPNIGDGNLPTLAQALQQAGITCGDNLDTLRKDIEKILKPYQILPEFAMRNGYFAGTGILSQAELIRVFETLRSQAQSLDDPLALELYETFKQRMLQTKLIDTDKKVYPVRAIVNRSIVDPRYLHSTALVNNLPKLEAAISNGEVLELNRFSGSGGYDYDPKSFFLAYPLQIVFSNLAWYLGFESVGGNEPGLLRFERLDRLFLGNQQNKTRYRSEQEKSLQKLQALLKGSAGLFLGNSEVEQSKFLSQDQKVHITACMTVELWFNNDVYKFITEGTKRFAKIKMSPPVSSTKNNLPKSIFSLKATKDKQFPHRFQVILPKWSLHDFDLWRWIVGFGGNVKVIEPIELVEKVKGIGSGIVQVYDTKK
>NC_019751|291354:360224|303003_303693_-|WP_015196013.1|DBSCAN-SWA
MGKSFSSLDEVAVKAQKAVIKAENESLSDEDRQQALLEKQIALTKLMTLLMERIKVELPKPGNVGLSEYIYEETLQNIYLYICKNIGKYNSDYSVMAWVKFLLKKRKNNVFNWLNWDGKVSYIDKGLNKDGDEYERNPLESYQPPSLNPLPSEKLIEFIKEDPEGLLASKLFKKNPQASFQAILLKKNEECKTWEEITQELNLGKTHGPIYSFYSRCCDEFSPYFKKYL
>NC_019751|291354:360224|338872_339235_+|WP_015196037.1|DBSCAN-SWA
MKTPQQIEAALNQFTGSTTLYKHWLGLKYTDGIKYLAEETSCYWLLDAIFSHQTKTFLSNQNLREFQIWYLRVENNSGVLICEWDTNQEVLRQEIEYTDFSLSHIKLYLIETVLMLPSEY
>NC_019751|291354:360224|352524_353130_-|WP_015196050.1|DBSCAN-SWA
MVTNSENPTLSMELPSSIGLRVTQAQFAALAAVNRDLKLERTAQGELIVNPPTGWETGKRNRSLTGQLDRWYEENENLGEAFDSSTGFILPNGATRSPDASWVSQARWDALTTEQKGTFANICPDFVVELRSSSDRLESLQQKMREYIENGATLAWLLNPQQRQVEIYRPGVEVEVLDNPSELSGEGVLPGFVFNLRRVWG
>NC_019751|291354:360224|304143_306417_+|WP_015196015.1|DBSCAN-SWA
MLSRNFLSQIAYEHELSPEQQQVFLMRIGDGLSYEEIAAQLNTSADACLKRMGQVYKKFNISGASRGKESKLRFFLTNRLEKVTEESSAHTQSIEEKKQETQPNSVAQNLPVREYTTFVGRDQEITRLMELLDFQHTAHLISVDGIGGVGKTTLVVEVAYRCLQASNNQLLTPNLPTFEAIIFTSAKQNHLTSIGILPRLTKERTLRDICREVARILDLSEITNLPIEEQFQPIREKLSQTRTLLIVDNLETIENQQEVLSFLYDLPPSVKVIITTREQALFVPIRLGCLPREHGLCLIQQEAQEKSINLTAEESQQLFEGVSGIPAAIIYVIGQIAAGYSLEDALSQIKEPDGDVARFCFAGSVIPLRGTPPHYLLMALSLGVKPITRETAASVAFEQADPILTSQGLAKLQQLSLVYHQQGRYSLLELTREYAASELAANRELAQQLQQRWVNWYIRFSEVYGGTNWKEWHLGYSYLEIEWENLRSVLEWCMSQGIYGDARTIWQQIKGYIHVRGYWDERLEWTAWLIETAKQAGDWKFTVEVMCDRAITLIRMRHENQLTEAEILLQEAWNLRQHQSIALQLEIATNMVILSIYQQKWQQAGEWLTEEEKLLTQTSLSELERQQQQVHILYYQGQISFKTGNYQQAQSFFLQALESATTAGWLRATTAIQNWLADIALELGNLKQARQLLEISFPMAERHKDKLSIAYHKATFAKLEKRSGNLPQAKRLAKEAAEGFESLKMVVEAKEMRSLLS
>NC_019751|291354:360224|337174_338395_+|WP_144051088.1|transposase|DBSCAN-SWA
MKVLTELLDLKDIKVTSQRIYNGIGIILQTESTKSYSICPHCGTKSEKLHQNHSHIIKDLPFSEKPVFLEVNRRQFKCYQCQKPFSEELYYAKKKRTYTNRLAQKIIQDVLESDIHSVASKGIVTTEEIERMLKDASEELCDSKPSNLKRLGIDEIALVKGKGDYCAVLVDLDASKLLAILNGRTQDKIKEALSGWGLEVLQQIEEVSIDLWQGYKNLVMELMPNAQVVADRFHVMTQINKELDTQRKRERRSIEEQIKETKSESEKAEYEIILAGLKNSKYSLLKNEDNLTDEQVVKLREVKRVSPVLKEMHDFKEKIRKIFNLTDHWYTGVFKLGMWLSKAKKYFPRSNNTIIRWFDEIIAYFDNGTTSGTVEGINNKLKLIKRSGYGFRNFQNFKIRCLLNWT
>NC_019751|291354:360224|332141_332951_+|WP_015196032.1|DBSCAN-SWA
MYKKAFGIIETLAPLHVGATAGEESGNLNLIFRDQFTQTGIIPGSSLRGRFRAEMRSQVDEKEVSYWYGEGASSEQSEINNESMVKFEHASIVWLPVFCPGQPIVWVSSPRLLERYKRIAQIDAEIPSLYVASSNIRARESQGKKTIFFNLGFLNIIRSENLSKWFPNGKELPAVIVDDSDIAMIHDMALYRQSRVRLKDNEKVVDGGGFFNTEALPEGTILVFPIAIRDDKSNKKWQPFPNDITDEIYLGGLESIGFGHCQLKIVNRN

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_144051088.1|291354_292575_-|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_015196009.1|292731_295848_-	hypothetical protein	NA	NA	NA	NA
WP_015196010.1|295916_297932_-	hypothetical protein	NA	NA	NA	NA
WP_051036588.1|298101_299709_-	hypothetical protein	NA	NA	NA	NA
WP_015196011.1|299635_300853_-|transposase	ISL3 family transposase	A0A2D1GQC1	Lysinibacillus_phage	1.5e-27	25.2
WP_083866289.1|301008_301866_-	caspase family protein	NA	NA	NA	NA
WP_015196012.1|301960_302929_-	DUF1822 family protein	NA	NA	NA	NA
WP_015196013.1|303003_303693_-	hypothetical protein	NA	NA	NA	NA
WP_015196014.1|303797_303959_+	hypothetical protein	NA	NA	NA	NA
WP_015196015.1|304143_306417_+	AAA family ATPase	NA	NA	NA	NA
WP_015196016.1|306437_306971_-	glycine-rich domain-containing protein-like	NA	NA	NA	NA
WP_015196017.1|307408_308317_-|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_015196018.1|308554_309154_-	hypothetical protein	NA	NA	NA	NA
WP_068972685.1|309454_313111_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_015196020.1|313459_314212_-	DUF4384 domain-containing protein	NA	NA	NA	NA
WP_015196021.1|314349_316356_+	CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_158333119.1|316385_316526_+	hypothetical protein	NA	NA	NA	NA
WP_015196022.1|317685_318726_+	CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_015196023.1|318737_319016_+	CRISPR-associated endonuclease Cas2	NA	NA	NA	NA
WP_015196024.1|319267_319537_+	hypothetical protein	NA	NA	NA	NA
WP_015196025.1|319633_319933_+	hypothetical protein	NA	NA	NA	NA
WP_015196027.1|320450_320843_+	hypothetical protein	NA	NA	NA	NA
WP_015196028.1|321419_321713_+	hypothetical protein	NA	NA	NA	NA
WP_144051089.1|322012_322243_+	hypothetical protein	NA	NA	NA	NA
WP_085953333.1|322570_323808_-|transposase	ISAzo13 family transposase	NA	NA	NA	NA
WP_015196030.1|325819_327913_-	WYL domain-containing protein	U5J9W1	Bacillus_phage	6.8e-09	33.1
WP_041738925.1|329011_329272_-	hypothetical protein	NA	NA	NA	NA
WP_015196031.1|329577_331143_+	hypothetical protein	NA	NA	NA	NA
WP_015196032.1|332141_332951_+	type III-B CRISPR module RAMP protein Cmr4	NA	NA	NA	NA
WP_015196033.1|333002_333431_+	hypothetical protein	NA	NA	NA	NA
WP_015196034.1|333427_335047_+	hypothetical protein	NA	NA	NA	NA
WP_015196035.1|335224_336832_+	hypothetical protein	NA	NA	NA	NA
WP_144051088.1|337174_338395_+|transposase	ISL3 family transposase	NA	NA	NA	NA
WP_015196036.1|338483_338750_+	hypothetical protein	NA	NA	NA	NA
WP_015196037.1|338872_339235_+	hypothetical protein	NA	NA	NA	NA
WP_015196038.1|339270_339516_+	hypothetical protein	NA	NA	NA	NA
WP_015196039.1|339676_340066_+	hypothetical protein	NA	NA	NA	NA
WP_015196040.1|341032_341302_+	hypothetical protein	NA	NA	NA	NA
WP_015196041.1|341372_341636_+	hypothetical protein	NA	NA	NA	NA
WP_015196042.1|341797_344047_+	ATP-dependent RecD-like DNA helicase	Q332G4	Clostridium_botulinum_C_phage	1.8e-55	26.5
WP_015196043.1|344174_345563_+	3' terminal RNA ribose 2'-O-methyltransferase Hen1	NA	NA	NA	NA
WP_015196044.1|345625_346075_+	ATP-binding protein	NA	NA	NA	NA
WP_015196045.1|346064_346844_+|tRNA	tRNA(His)-5'-guanylyltransferase	G3MAB9	Bacillus_virus	3.2e-20	30.3
WP_015196046.1|346886_349463_+	polynucleotide kinase-phosphatase	A0A1V0SF21	Hokovirus	1.3e-25	23.0
WP_015196047.1|349673_350186_-	hypothetical protein	NA	NA	NA	NA
WP_015196048.1|350295_350550_-	hypothetical protein	NA	NA	NA	NA
WP_158333120.1|350750_350897_-	hypothetical protein	NA	NA	NA	NA
WP_015196050.1|352524_353130_-	Uma2 family endonuclease	NA	NA	NA	NA
WP_015196051.1|353424_355551_-	NACHT domain-containing protein	NA	NA	NA	NA
WP_085953333.1|358986_360224_-|transposase	ISAzo13 family transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NC_019751|2803324:2918529|DBSCAN-SWA
TATGAATGAAAACTGCCTCCCCTATGGAATAGAAATTCCTGACTCAGATTGGGAAGAAACTCCAGCCAGTGTCAAACAACTGGTGGAGAAAATGGAGCAGTACATAAAAGAATCGGATAAAAGGTTTGCTTCCTTAGAAGCCAAATACCAGGAATTGTTAGAAAAAATCAATCGAACATCAAAAAACTCCTCATCTCCCCCGTCAAGCGATCCACTCAATAGCGAAAAACAAAAGCAAAAAAAGAAGAGTGATAAAAAGCGAGGCGGACAACCGGGACATAAAGGGCATAGCCGTCATCTGTATGAAGTATCGGAATGCGACAGCGTTCTAGAACATCAGCCAGAAAAATGTAAGTGTTGTGGAGAAAAGTTAGTAGGAGTTGATAGCAATCCCGTAAGGCATCAAGTAGTCGAAATCCCGCCAATAAATCCCATAATCGTAGAACATCGACTACATCAACTCGAATGTCAACATTGTGGAACCTTGACTCGTGCAACATTACCGGCAGATGTACCAATTCGCGGTTACGGTGTAAGGGTAGTGGCACTTGTCGCAGTATTGAGTGGACTATACCGTCAAAGTACCCGAATGGTACAAAGTGCGATGCAAGATATTTTTGGAGTCAGGATGTGCTTGGGTACAGTCAATAAACTGAGACTCGAAGCAAGCGATGCAATTGCAGGAGCGGTATTAGAAGCAAAGACATACGTGCAAAACTCTCCTGTAGTTGGAGCGGATGAAACAAGCTTTAGTCAAGGAAACGTTGATGGATGTAATGACAAAAATAAAAAGGCTTGGCTGTGGGTTGCAGTCACACCGCTAGTTACATTTTTTCAAGTCACACTTTCCCGTTGTACGGATACAGCCAAAAATTTACTGGGGGAAAACTTCGGTGGTATTTTAAACTCCGACCGATATGCATCGTATAACTGGGTTGACTTGGAGCAACGGCAGTTATGTTGGGCACATTTAAAACGGGAATTTATTAAAATATCTGAGCGTTCTGGAGTTTCATCAAGTATTGGTAATGCTCTGGTTGAACAGCAAGAAAAATTATTTGAATTGTGGCATCGGGTTCGAGATGGAACTTTGAGCCGTTGCGAGTTTCAACTTTTAGTCCCACAGATTCGCAATTTAATCAAGTCGAACTTACAAGAAGCTGCGGATTATAAGATTGGCTCTCAGGAAAAAACTCCACTGGCAAAAACCGTTCGTACCTGTCGTCAACTCTTAAAAGTTGAGCAAGCTTTGTGGCTGTTTGTCGAAGTTGAGGGTGTGGAGCCGACAAATAATGCTGCGGAAAGGGCTATACGTCCTGCCGTGATCTGGAGACGTACTAGTTTTGGTTCTCAAACAAAAGCTGGTAGTAATTTTGTTGCCCGCATGTTGACTGTTGTTACAACGCTTAAGTCTCAACGTCGCAACATCCTGGATTTTATGACACAAGCTGTGAGCGCTCAACGTCTTAGTCACAACTCTCCTTCTTTGCTGCCGCAAAATTCTGTTAATTCGATTTCTGTTAAAAACACTGCTTAAAATCTACGCAGTTATGCTGCCGACTGCCAATTTGTATACACCTCTCAAACTCAACATGTAGAAGGTTTTGACTGTTTTTAATTTGTAGTCACCCGTGGTCGATTACCTTTTTACACTTGTCTACAAATTCTGGTGTAACAGCAAAAAAGCTCATTCCATTAAATTGATTACCAGCAAAAAAATGAAAGATATTTTGAAAGGCTGCTTTTTGATGAGCGATGTTAGTAATATTAGATAAAATATCTTCAAATTCATCAAAAAGTATAATCAATCCCTTTAATCTAGAAGCACAAGCAAGTGTATTAATATCTCTTAATGTAGACCAACATTGTGCATAAGCTTCAGATTTAAAGTTAAATACAATTGAATTATTTGTATAGTGTTGCCATTTAAAAGGGTTGCTTAGTGAAAGTTCATCCCGGTAAGTCATCCGAGTTTTATGTACTAACTCCTCATAAACTTGCTTTTGTTTGTAATTTCCTGCTTGAAATAGCCAGTCTTCAATTATAGCCTTGTCACATCTACCGCTAAACCAAGCACGTAAAGCAATAAAATTAGCAGGTGAATCAAGAACTTGAGAAAAATCCCATTTACCTTTCAATACCTTCGCCAAAGTAAGAGGATGAAGAGGAAGAGGTAGGGCGTTTCGTAGTAGAGTTATTGTCTCTCACAACGACAACTCAAAAACCACTATGTGCGCCCATGTTTGACATTTTATCATTGTTACAGTGCTTCCTGCCGCAGATAAATGCTACAACGATGAAGCAATTGAACCAAATAATCTTGGCAATGTTAGCGATGAGCGGGCGAGTCACTATGTTGGGAATTTCTCGTTGGACAGGTAGTGGTGGTAGTTATCGGACGATGTTGAGATTTTTTCATACGGTAATCCCTTGGGCGACATTGTTTTGGCTATTTTTCCGCAAGCATTTGTTCCGTGCAAATGAGGTTTATTTGCTTGCAGGAGATGAAGTTGTAGTAAGTAAATCTGGGAAAAAAACTTATGGGTTGGATAGATTCTTTTCCAGCCTAGTAAGTAAGCCAATATCAGGGCTATCTTTCTTTACATTATCATTAGTAAGTGTTGAACAAAGGCACTCATTTCCGATTCAAATAGAACAGGTAATAAAGAACGATATAGAAAAAAGTAGTGTATCGCCAAGACCAGAAATAAAAGCCAAAGAAAAACGTGGACGTGGACGACCAAAAGGGAGTAAAAATAAAAACAAGACCGAAGTAATTCTCACATCTGAATTACTCAGAATTAAGAAGATGATTAATGAGCTAGTCAAGCTGGTAGCTAACTTTATCCCACTGACTTACTTAGTCTTAGATGGTCATTTTGGAAACAATAATGCTTTGCAGATGGCTCGACAGGTCAACTTACATATAATTTCCAAGTTACGCCACGATTCAGCATTATACATACCTTACCAAAATCCTGACCCTAATCATCGTTCACGCCGTAAATACGGAGATAAACTAGACTGGCGTAATATTTCTGATGAATATTTGCGTCAAAGTAGTATCGAAGAGGATATCCAAACCGATAGTTACCAAGCTACTTTACTGCACAAAGAATTTGCCCAGTCCCTGAATGTAGTTATTTTGGTGAAAACAAATCTGAAAACTAATGCTCGCAGTCACGTAATTCTGTTTTCTAGTGACCTAAAGTTGTCATCTGAGAAAATAATTGACTACTACAAACTACGCTTTCAGATCGAGTTTAACTTCCGTGATGCCAAGCAATTTTGGGGATTGGAAGACTTTATGAACATCGGTCAAACTGCGGTGACTAATGCTGCTAATCTAGCATTCTTTATGGTTAATTTATCTCATCATCTTCTCGCTGATTTCCGCATCCTGAATCCTGACTCCGGCATTATTGATCTTAAGGCTCATTATCGTGGCTTTCGATATGTCCATGAGATCTTAAAAATGCTTCCAGAAATCCCTGAGCCTATTTTATTAACCCGGATTTTTGCCAAGCTTACTTCTTTAGGGCGTATTCATCACGTTTCTACGGGCGTTGAATCCTCTTAATTTGGCAGAGGTATTGACCTTTATTAGTTATTTTTGCCCATTCATCTCCTTTTGTACCTGTACTACTACGAGCTTGCTGACAGACAAAATCAAAAAAGGGTCGAACGCCTTTATTTTCAGCATTGCCCGGTATTTCTAAACCTCGCCATATAGCCCCTAAAATCTGATCCATACGATTGAAGCGAATGCCTGATTTGGCATCTAGCGTTACTGAACTAATCGCAAAGCCTTCTTTCAGAGCAGTTTCACGAATAAACCGTAACAAGTGGCTTTTACCAGAGCCATAATTTGCTTTTAGTAACAGCGCTCCTGATTTTTCCTGCTGAAGCCTTGCTGTAAGTTGGGCTATCTCTGATATTCTGCCTACTGTAAAATAACGAATATAACCACTAGGAGGAATACCCAAACGAAGGGATTCAATAACTCCTTGCACCTCTGTACTCATAAATTAATCCTCTCGTAGGCGATCCATTACATCACCGTAAATTGTTTCTGTTGTTCTGACTTCTCCTTCTAAATAGTCATCTAAATGAGCAATTAGAGTAGTAACTAAAACTCGCCAAAAACGTACACCGCTAAGTGAAGGGTGAATCTCAAATAATTCTTTCACGAAAGCATTAATTCCTGCTTCAGAGGGTAATTCTACAGATGCTTCTAGATATGCACTTGCATAAATACTACAAATTTTCTCCGCAGCAGCTTGGTATTCAGATAAGTTTGTTTCTACTTCGTCTAAATTCCAAACAGAGTCTAAAGCTCGTGGTTTACGCTGTTCTGGCTTACCAATTCTTCCTTGCAAAGCACCGTAAATAATAATGCCATGTTTTGGGTCAGTAAAAAAGTCTGGAGTCGTAGCATAGATTAGAAATAAACCGTTAAGAGACTCAATGTTGTTGATTAAAGACAAAAGGTTATTGTGAGCATCTCTCAACGAAGATTTTCGCATAATAGAATATGCTTGTTCTGCTTCATCAAATAATATTACTAAACCTTTGTAGCCGGAAAGCCTTACAAATCCAGCCAAAGATTGCAACATTATTTTTGCGTTATCTTTGTTAACTATTTTGTTAACTTCAAATTTTCTGCGATACGTTGCTAAACTTCCTTCTCCACTGAACCATTGGAGAATCTCGGCTCTATTTTGCTCTTGAAGTGCTACATCAGGGGCTTCAGGTAAAAAAGTTTCCCAATATTTTTGAATCATCTTCTTAAAATCTATGTCAATGCTGCGATCGAGCATGAGTGTTTCTCTTGCCTTGACATACTCTTCATAGGAAAATATGTTACTAATTTTACCATTAGCAAGATAGGCTAAAGATTCTTGCAATACTCGTCCAAAAGGAGTAGTTTCATAAAAACTATTCTCAGAAAAATACTCTGGAGTTGAAATACTACGAACAATTGAATAAAATACTTTCTCAAACTTGTTTAATGCTGCATCATCTGCGTTCAGTTGTACATTTGAAACTAAACATTCATTTTGAAAAGCAACTTCTCTTAATAATCTGAAAAAGTGAGTTTTACCAGAACCCCAAGAGCCACTTAAAAAGCGAATAATACCTCGTTCTGTTATTCCGTTAAAATGATGTTTTTTAATACCTTCAATTAATTTCTCATTACCTACTGAGTATTTATCAACCCCACGCATCGGAGGAATTCCTTTGCGTAATGATTCAACAATCTGTGTAGCGATGCGCCCTTCCATAATTAAACCTTTTTAAATAAAATTGAACCTATATAACGCTTGTTTTCGATATGAAGAAGAAGTCCCTGAGTCGTATCTTTGGTTTGTGTAAACTCAAATTTTCTACCTTCTATCTCTGTAAAATTTTGCTCAACTAATCGAGATAAATCGATTAGAAATTCATCTGTGCGAAACCCTTTTTCGTTTTTTCCCAAACGGCGGGTAATATCTCGAATAGGGATACTACTACCATCAGTTAGCTTCTGCTTTTTGATAACTTCTAGATACTGCTTACGTAGCTTTTTAAGGAAAACTTTTGCATCAAATTTTCTTCCAAAAACTCGTTTTTGTTCGCGTTGTACTGCTTCAATGATTGCTCCAACGTCGGCAGGTACTTCACAAAGTTTGGGTAATTCATAGTCAGATAAACGCGCAGTTTTTTTGTGGTCATCTATACGAATCTGAAAGAAACCGTTTTCAAATTTGTAGTTAGGATGAGTGCTATCACGATCTAAGGGTAAATTAGCTACACGGCAAGCCTCTTCTAATTCACGAGGAAAGAAGTGATATTTTATTTGTGAGGCTTCCTCTTTAGCTATTTGGTAAATTTCCTCCAAAAATGAAATAGTAGAATGGTTATCAACTTTCATTTTTTTCAAGAGCGGGTCTTGTTTGTCGATCGCATCCAAAAGATGTAAAGTCCAACCTCGCTTCAGATATGAGGTTACGTTTTGGCATAGCTTTTGAATGCTTGCAGCTTCATCTGCTTGGGCTTGAAGTCCTTTTGCTTTCTGATCTGCCTTCGCTGTTTGCTCTTCGGCAATATTTAAGAGAGATTCTGGAAAGTGATTAGCTGTTGTCATGGCTCAGTTTTCATAAGCTGTATGTCACAGTTGTTTATTTAAGCTTCTGTATTTATTATTCCCTTTTTGTTATAAAAATCACATTTTATTTACGTAACTGTAGAAAATTACTCGAATCTTGCCTAATTAAAGATTGCTGCCCACAATCCTGCGTGTTGGTGGCAAAGTTCAACTTAACGATAGAAAATGCATTGCGATCTGTCGTAGGCGGCAGCACTGTCTGCCTTGCACACGCTACGCGATCGCATCGAACTTCATCAAAATACTGAAGCCTTGCTGTAAACCACGATAAAATCAGGTTTTTGTCCTATAATTATCAACGCTATGTAAAGCTGCTCATTTATCTCTGTACGGAAACCGATGATTCAGCGATCGCTGTTTGATGCCCCTATTACATTACAAGAACTAGAATCTCATCTATGGGAGGCAGCAAATATACTACGTGGTAGTCCTGTTGACCGTACTGATTGGAAAAGTTATATTTTGCCGTTGCTGTTCTTCAAGCGCATTTGCGATGTTTGGGATGAAGAATGTCAAAAAATGATTGAGGAATATGGAGAAAATTTCCCTGACGAACACCGCTTCCAAATTCCTGAAGTAAGCCACTGGCAAGATGTGCGCTCGACATCTAGTAATGTTGGTACTGCCTTGCAAAATGCCTTGCGTAATATTGAAGTTGCTAATCAAAAACATTTGTATGGTGTATTCGGCGATGCTCAGTGGACAAATAAAGAAAAGTTATCTGATGAACTGCTCAAAGACCTAATTGAACATTTCTCTGCACTCAATATTAGTAACAAGCGCGTCCACAATGATGTTATGGGGGATGCTTACGAGTATCTGATTAAAAAGTTTGCCGATACGACCAAGAATAAAGCGGGAGAATTTTACACGCCGCGTAGTGTGGTACATCTGATGGTGGATATGTTAGACCCCCAGGAAGGGGAAACAGTTTACGATCCAGCTTGCGGTACGGGGGGAATGTTACTTGCTGCTGTTGCCCATGTACGAAATAAGGGAGGGGATGCAAGGACGTTTTTTGGTAAGTTATACGGGCAAGAGAAGAATTTAACAACTGCTGCTACTGCCCGGATGAATTTATTTCTCCACGAAGTTGAGGATTTTATCATCGAACGGGGTGATACGCTGCGTAACCCTGTTTTTACTGCCAATACGGGTGGTTTGGCAGAATTTGATGTGGTAATTGCCAATCCTCCCTTCTCCTTAGAAAAATGGGGACGGGAAATTTGGGAAACTGACCCCTGGGGACGGGCTTTTGCGGGTTTACCTACGGATAGTAGTGGTGATTTTGCCTGGGTGCAACACATGGTTAAGTCTATGGCTAAACCACATGGACGGATGGCTGTGGTGTTACCCCAAGGTGCATTATTTCGTGGGGGAATAGAAGGACAAATTCGCCGCACTTTGCTAGAAATGGACATGATTGAAGCGGTAATTGGACTAGCACCAAACTTGTTTTACGGTACTGGTTTGGCTGCTTGTATACTGATACTGCGTCAACGTAAAACTCAAGAAAAAGCAGGTAAATTGCTAATTGTTGATGCTTCAGCAGTATTCCGTAAAGGACGCGCTCAAAACTTTTTAGAACCAGAACACGCTGCGGAAATTCTGCGCTGGTATCAAGAATTTACGGATGTGGAAGATCGTGCGCGGGTGGTTTCTTTGGAGGAAATTGAAAAGGAAGGATGGACGCTGAATATATCACGTTATGTTTTACCGCCCATCGGAGCAGATATTCCACCCCTAGAGGAAGCGATCGCATCATTCAAAGATGCTTTGGTACAATGCCGAGAAGCTGAGGAACGTTTGCATCAGGTAATGTTAGAGGGGGGATGGCTGGAGTGATAGCACAAATTACACAACAAGCCTTAGAGAGTTATCTTTGGGGTACAGCCACCATTTTGCGGGGGTTAGTTGATGCGGGTGATTACAAGCAATATGTCTTTCCCTTGCTATTTTATAAGCGGTTATCTGATGTTTGGGATGAGGAATTTGCTCAAGCTTTAGCTGATACGGGTGATGATAATTATGCCCGTGACACTGCTAATGACCGTTTTATTATCCCCGATGGCGCTCACTGGAAAGATGTGCGGATTGTTGCTAAGGATGTTGGTAAAGCTTTACAGGATGCGATGCGGGTGATTGAAACTGCTAACCCTGGTCGCTTGGATGGTATTTTTGGGGATGCACCTTGGACAAATAAGGAACGTTTACCCGATTCCGTAATTAAGAATCTGTTGGAACATTTTTCGACTGTAATGCTTTCCCTGGCGAATGTTCCCGAAGATGAATTAGGGAACGCCTACGAGTATTTAATTAAACAATTTGCTGACGATAGCGGACATACAGCCCAGGAATTTTATACCAACCGCACCGTGGTTTATTTAATGGTGCAGATGCTCGCACCAAAATCAGGCGATCGCATTTACGATCCAACTTGCGGTACGGGGGGAATGTTGATTTCGGCATTGACTGAGGTTAAGCGTACAGGTGGAGAACATCGTACCCTCAAGCTTTACGGGCAGGAACGCAACCACATGACCGCTTCGATTGCTCGCATGAACTTGGTACTACATGGTGTCGGTGATTACCAAGTTATGCGCGGGGATACTTTGGAACGTCCTGCTTTTACTGAAAGCGATCGATTGCGGGTTTTTGATGTAGTTCTCGCCAATCCACCCTACTCGATTAAACAGTGGAACCGGGAAGGGTTTCAAACAGACCCTTGGCAACGTAATTTTTTGGGGACACCCCCTCAAGGAAGGGCTGACTATACTTTTTTTCAGCACATTTTAAAAAGTCTTGACCCCAAAACCGGACGCTGTGCAATTCTCTTCCCGCATGGGGTGCTGTTTCGTAAGGAAGAAGCCCAGATGAGGCAAAAGCTGGTTGAGGCTGATTTGGTCGAATGTGTCCTTGGTTTGGCACCAAACCTGTTTTATAATTCACCGATGGAAGCTTGTATTATTGTTTGCCGTACTCGTAAGCCTAAAGAGCGGCAAGGACGGATTTTATTTATTGATGCAGTCCATGAAGTAGCTCGTATGCAGGGGCAAAGTTTCCTCAAGCCGGAGCATCAGTTACGTATTCTCAATGCCTATCAAAGTTATATTGATGACCCTGGTTTTGCTAAGGTCGCAACTTTAGAGGAAATCGCTAATCAGGATTATAGTTTATCGATTCCGCTTTATGTGCGGCGTACATCAGCCAATAACCAAACGGAGGAAGTCAAGACACTGCGGGAAGTTTGGGATGATTGGGAACAGGGCAGTAGGGCTTTTTGGCTAGAGATGGATGCTTTGGTTGATATGCTAGATTCTTTGGAAACATAAAAAATTATTTACCAATATGGTAATGTATTCTCTGATGTAAATTAGCTATGAGCTATAAGAAAATTATTTACTATTTTGGTAAAGATTTGAATAAATTGATATGATATCTACCTTGAAGTCTAATCAATTTGTTTACCAAAATGGTAAACTTGTATTAGGCTACTAAAGCATGGAAATTACTTTCGCTGACAGCAAACTGCAAAACCTATGCGAGCAAGAAAAACTAGCAAAAAGAAAATTGGGTGCAAACTGCGCGAAGAAATTGAAAACCCAGTTGACTAAGTAGGTAGGCAAGAAAAAACCAAACTATGTAAAGATAAGTAAATACGGAGAATGCATCTACCGAGGTGACTTAATATATGGGCGCTCGTTTAAGGATATTCTTGACTCGTGAGCAAGACAAAACCCTGTTACAGCTAAGAACTGCGGAAGTACCACAGAAAGTAAAAGATCGAGCAGAAATAATTAGGCTAAATGCACATGGCTGGTATGTAGAAAAAATAGCTGCTCACTTTAATTTGACTCAACAAACGGTAAGAGAGGTTTTACACAGCTGGAAAAACAAAGGTCTAGAAGGACTTTGGGAACTACCTGGTCGAGGGGGAAAGTCAAAATGGCAAGAAGAAGACATCATATTTTTGGAAGAATGCCTGAAAAACGAACCGCGTACATACAATAGCCTTCAACTCGCACAAAAATTAGAACGCGATCGCTCAATTAAACTGAGTCCCGACAGATTAAGGCGGGTGCTCAAAAAAAGGGGGTCAATTGGAAGCGAGCAAGGAAGAGTCACAAAGGCAAGCAAAACCCGATAGCACGAGCAAACAAACAAGCAGACCTAGATATGTTGGAATTATCTGCTGCGTCTGGAGAAATAGACCTAAAGTATCTAGATGAATCAGGATTTTGTGTATGGAGCGAACCAGGTTACACTTATTACTTCAAAGGTGAGCAAAAACGTTTAGAGCAAACCCAGCGTCGTGGACGGAGATTAAGTATTATCGGCTTTCTTCAACCTTTAATCAGCTTTGTTTACGGTCTGGTGATTGGTGCTGTTAGTCGTAAATCTTACATCGAGATGATGGAAATAGAAGCAACTGAAGCTCAAAGAACGGGGCGCATTAGGGTAATTGTGCAGGATAACGGATCGATACACCGATGTAAAGAAGTGCAAAAGCTATGGTCCAAGTGGGAAAACATGGGTTTGTACATCTTTTTTCTGCCCGCATACTGCTCCGAGATGAACCCAATTGAATTAGAGTGGCAGCACCTAAAAAAAGACGAACTACGTGGGCAAACATTTGATGACGAGTTAGACCTCGCTTACGCCGTGATTGATGGCGTTAAAGCTAGAGGGGAAAAAAGTAACTACAGTACAAGACGTATTAAATTTGACTCTAGTCGCTCTGGTTAAATTTTCGTTACATAGTTATAAATTTTCTCGCCCACCTACTTACACTACACAAGCTTGATCAGCAAGTGCCTTGAAAGCTTGTTGCGGGATTAGACCTGATTCCCAACGGATGTCTTCCTCTTTTACTGATTGGACATCAAGTGGACCTAGCTCACCAAAATCCGACATCACGATATTTTTGGCAGCAAGTGCTATAATCGTGCCTGCACTTTTACAAAATCCGAAAATATAAAAAGTGAGTTGATCATTATATTCTCTCTTCAAAAATCTGGCTAACATAAAAGCCGCATCTGCATCTCCCCCAGGTGTAGTTAGAATTAAGCTGATATTCTTCCTTCGATGCTCTAGTTTTTTAACTTGATTGATTAAAATGTCAGTAGCAGCATAATCAATTGAGCTGCTGAACAAAAAGAGATCTGTATCAAAGTCATTCACGATTTGCGAAACTGGATTGCGTAATTCAGTTGTTTCCTTGGCTTGAAAAATCATAGTATGCTCCTATGGTGTTAAGTTTTAATGCTTCGATTCACACAGAAAAAAGGTGACATGCTCCCGATGACTAATTATTCAAGAAGACTAAAATGCTTGGTTGGAAAACGTGTTAGATTTTATGCTTCAATTCAGCGTACAGGGAGGGGCGATCGCGGTTGTCCACTTAGAACTAACAACTTGCTCATTAATTTCAGACTCAATAACTCTCATGTTCATTTCCTTTTAAATTTATCTAAAAAATTTGATGGATCAATTTTGTACAAATTGTGGTGTTGATTTGCAATTTGTAATAGAAATTGCACCTTGGCTTAACCCAACCAGTTGAGCGACTCGAAACGCAGAAGCGATCGCTCCTTCATGCAAACCATCACCAAGATAGGCTCCTGCATGGTAGGTATTGTTCTCGCCATTAGTGGCAACTACTTCATTTCGATATTGAAAAGATTCAGTAGTATATAACGGGGTATGATGTTCCTGAATGTGAATGATGCGATTGCTAGCAATTAACTCCTCTAGTTGGAACGAGAGAAAATAATTTGGTGGTGATGAGATGTCACATATCTGATTCAGGCAACTGTTATAACCCCATCGGCTTTCTGTCTCAAAAAAATCAAATTCTGATGGTTGTTTAATGCCATAGCGGGTGTATATGGAACTATCTGTATGGAGTAAGGTCGTTGCATAATTGGCTTTCCAGGCAGAAAACCGTTTGATTTCGGCATCAGTTGGATCTGCTAACAGCGCCATCACTTGGTCAGGTGGCGTAGCAAACACGACTTTATCAAACTCCTGAATTTCACCCGTCCTTCGCACAATTTTCACAGCATCCGAGGTTCTGAAAATCCGGTCAATCTGCACATTCAGCAAAACCTCACCTTTGAATCGTGCCAGAATTTTTTCAATGTAAGAATACACACCACCTTTAATCCTGACCCAGCTAACTGCGACATCCTTGAGTAAAACAGGCATCGCCAATTCTGCTGGGAAATCATCAATCAGTTCCAATGGCATCGAATAGCTATACATAACTAGCAATTTTAGCCAAGTATTGCGAGTACAGGGGCGTTTCAGGTATTGCGACAAAGGCTGATTGTAGAAATCTTGCAGGTGAGCAAATCTTATTCTGAGCCAAAATCCAGCAGAACGAGCATAGAGGGTATCGAGGCGTAAATATTCGATCAGGTGGCGAATACCTGTGAAGTTCTTCTTGATTGCAATTTTTGATAGAAAGTGGCTGCCATTTTTGAAAAAGATTGCTGAACTCATATTGACAGGTTCTAGTTCTACCCCTAACTGTTCCATGAGGGCAATGAAGTTGTGAAACACAGTTGGAAATTCCAGCACTCCATTTTCCAAAATTTCCTGACAATCGGATTGATTTGGGTGAACATTCTTGTTGAGTGTCTGAATATGTCCACCTAGAGTAGATTGCCGTTCAAACACAGTCACACTATGCCCTTGTTTATCGAGTAGGTAAGCTGTCACCATGCCACTAGCTCCCCCCCCAACGATAGCGATCTTCATAATTTGCCTCTCAACTATATAGATATAGATAATGTGGTAGGTGTAACCTATCGTAGACATCACCTGTTTAGCTGTTGCCTAAAATCATGTCACCGGATAACCGTTGATACAGCAGTGCGCCTGTCCAAAAAGTGGCAGCAAAGCCCGGATAGCCAGATGAGGCATTGCAGAAATAGAAATGGTTGAGTGAGGTTTCGTGATTCAGTCGCCCCATACCCATATTGCGCGGTATCAAACTGGAGCCGTAGGAATTCCCATTGGGACACCAGCAAAAACGCTCATTGGTAGTAGGGCTACCTGTAATGTGAAAGACCATATATTTTCTAAAGTTAGGTACATAGTGTTCTTCCACAACATCGAGGATGGAGTCTAAGATTTCTTGTTTTTTCTGGTTGTAAGCTTTGCGGTCATTATCTCGTAATTCCTGGAAGTAGTTGTAATTAGCAACAGTGAGGAATTCCACAATCTGGGAGTCTTCTGGGCAATCCCCACTCGCTGTAGTCAATAAAGTGGGTGTTGTGATGGCAAAACTAGGATTAGAAAAGTCATTGCGATCATACATCTGTGCAAAGGCTTCATTTAGATCGTGATGCCCTGTATGAAAAAGATTCCACTTGCCAAATCCATACTCTCGCAGGTCGATATCTTTGACGACGCAATAAGCCATGTAGTTAGATGCCGAATATTCATAGTTGAGTTTTCGGCGCACACTTTTAGAAAACTGCGATTCCCCGATCATCTTGGCGGCTTTTTTGGGGTCAATATTGCAAATTACGGTGTCGCCTGTAAATTCATGTGTTTGATGGGTAGTGAGATCCATCGCCTGAACTCCCGTAACCGTTCTGTCTGTGACTCTAAAATTCGTAACTTCATGGTTGAGCAATACCTGTCCCCCATGCGATTCAATGACATTGACCAAGGAATTAATCACATGTTCAAAATGCTGGGTTGGGTAAAATGCACCCGCTTGATAGCCTCGGAACAATATAACCCAAGCATAGAATGAAAGTTGATTGGGAGGGAGCAAAAAATCAGGCCATTGCAGGGCTAATAAGGTTTGAGCGGCTTGGGGTAGCTGAAACTTATCAAATACATCCTGGAGTGTGCTATTGAGATACTGGACAGCAGAAAATACCTCATTTGAATGTTTGAGCAGTTCAATTGGCTTGATCGGTGGAGAGAGTTTTTTCAAACCTGCACCAGTCTTTTCCACTTCGTTGACAAATTTGCGAATCAGATCGCCATGAGCGGGAAACAGAGCAGACAATCGCTGGATCAGTTCTTCTGGCTCCGAGGGAATATCCAAACTATGCTCTGGCGATCGCATGTGATCAAAGCCTTCCGAGTCATAACGTTCAAAAGTTACTTCTTGCTCTAACCCTAATTTTTTGAGTACCCGATTGACGGTTTGCCCTTCACCGCAGTCCCAAACATAGTGAAATTGAGCATTAAACGTATATTTTTTAGCCATCGTAAACGTATGCCCAAAACCTCCGGGATGCTCATGGGCTTCGAGAATTTGCACAGTCTTGCCAGACTTTGCCATCAAAGCGCCAAAGACTAATGCTGATAAACCACTACCGACAATCAGGTAATCCGGTTTCATAAGAGAGTTCCTCGAAAAATAAAAATCTGAGTTCTGTCCCGTTGAAACGCCCGTTAGTAAAGGCAAAACTTACTTAAACGCTTTGGCTAAAGCCTAAAACTGCACACGCAATGAATTGTCTGAGGCAAGGCACAACTAGCTTGGGAGGCAAGCTAATCCAATTTCACCACCATCTTGCCAACATTTTTTCCTTCAAATAGTCCGATGAACGCGCTCACTGCTTGGTCGATTCCGACTACCACTGTTTCCTTGTTCTTCAGTTTTCCGTCTCGGAAATATTTACCTACTTCCTGTTCAAATTCTTTCTGATGAGCTAGCCAATCACTAACAATTAGTCCCTTCATCGTTAACCGTTTAGTAATCATATTAAATAGATTAGAAGGACCAGGCTGCTTCTCCTGATTGTAACCAGAAATGCCACCACAAGCGATAATCCGCCCATGTACTTTTAATACCGAGAGCGCCGCTTCGAGCATTTCACCTCCCACATTATCAAAATAGACATCAATCCCATCTGGAACCTCTCGGTTCAATTGTTCGAGGATAGGAGCGGCTTTATAATCAAAAGCGATATCAAATCCACATTCTTCCCGTAGGAACTTGACTTTTTCCATGGAACCTGCGGAACCGATTGTACGGCATCCACGCAATTTGGCTAGTTGCCCAGCCACACTTCCCACCGCACCTGCGGCTCCCGAAATAAAAATCACATCGTCAGCTTTGACGTTTACCAAATTTAATCCCACCCAAGCAGTCATGCCCGTCATCCCAAGAGCACCGAGATAAACTGATAATGGTTGCACCTCCTGGCTGACTAGATGCAACTCTTTTGGTGCTGCGATGAAGTATTCTCGCCAGCCAAAGCTGGAAGTCACAATATCGCCATGATTGAATTCCTTAGCGCGTGACTCTAATACTTCGCCAACTGCGCCGCCATTAAGTGGTTTGCCTAACTCGAAAGGTGGAACATATGATTTCCTGTCGCTCATACGACCACGCATATATGGGTCAACTGACATATAGAGATTGCGAACAAGTACCTGCCCATCTTGAAGTGGCTCTAGTTTGGTTTGCGCGATCGCAAAGTTATCTGCGTTGGGAAGTCCGTTAGGGTAAGAAACTAGCACAACCTCGCGACTGATTACATCTGTCATAATTTGCTCCTGATTATCCACCTTTTCAGTAAACTTACTTAAATGCTTTGACTAAAGCCTCAAACTGCACATGCAGTGACTTGTCGTGGTGCGAAATAGGTGGGATGGGGCGATCTATACTTAAAAATTCGTAGACTGCCATCTGAGCGGCTCGCACCGAATACTCGACTGTGAAGACGACATCATCAGGAATTTCCACAAACTGACTGATTAAGGCGAGGTTTTTGGAGCTACGAGGGATCGGTAACGGTCGATCGCTACGTAAACGAGGCATAAACATACTGGTGATATAGGGCATTCTGCAAGGAATACAGTTTGCCGATTCCACAATGTCCAAATCAAAGCGGAGATGACCGCAGAGTTCGCGGAGAATTTCTTCACCGTTACATTCATCCATCGGTTTAGGCACAAAATTACCCACGCGATCGGGCAAAAGTGCATATCCCCAGAACACCTGGACATCAGCAGGCTGATTGATAAAATGGGGTTGATAGGCAAGCACGATAGACATCAGCCAGTTAGAGTCTTTAAACGTGATCAATCCGCCAGTCCCCGCTTGATTGCCACTAAATTCCAGGATCTTGTCGAAGAATTTAGGGTTTTTCAGGGTGACGGTAAAAGACTCCCAGCAAGATTCAGCAATACTGCTATTAAAAGCAGCAGGATTCCCAAAATCAGGGTTTTCTGCTGCCAGCTTTTCCCATAAATTCCAACTAGTACAGTCCTGTTTCGTCAGCTTCTTGGGCGCACTAGTCATAGAACCCAGACTTGAGGCATCAGTCATCGAGCCGTTTTGCAGAAAAACCAGATCGCCATCTTTAACCGAGATGGTTTTGCTTTCACCACTTTGTTGATAATGAATGCCTGTCACTACCAACTTCCCCTTTGCGGTGGTGCGTTCCAGATCCATCACCTGGCAATCTAAGACAAAATGGACATTTTGGGTAGCCAGCCAACTCTTTAAGGGCAGAATCAATGAATCATACTGATTGTAAATGGTACGTTTAACCCCACCCAGGGTTTCAATTCGAGTAAATTCCAGCATGAAGCGATGCAAATAACGCTTGAATTCAACAGCACTGTGCCACGGTTGGAAGGCAAACGTAGTCACCCACATATACCAAAATTCAGTCTCGAAAAATTCTGGAGACAGCCAATCTGTAATACAACTAGCACCTAACTCAGCTTCACCAGCTTGGGTAAGCTTGAGTAATTCTTGACGATTTGCCATGGAAAAGCCCATGGAACTTACCGGAACTTTCCCCCGACGACGATCAACTAGACGCGCCATCGAATTTGACTTGTGCTGCTGATTAAACTCCATTGTTTCGTCAAATACTGACTTCCCAGGGAAATTTAGGGAGGGAATTGATTTGAATAAATCCCAAGTGCATTCGTAATTGTCGGTTGTCAACATTCGCCCACCACGTAACGAATAGCCATCGGTAGGGTTTCCGGCTCCATCCATACTTCCCCCCACGACGGACTTTACCTCCAGAATGAAAATATTTTCCCCACAGAAGCCATCATCGCGGATCATAAAGGCTGCGGCTGCCATAGAGCCAATACCACCACCTAGTAAATAAGCATTCAGTTCATTACCCATGTCAATTAACTCCCAAATAAGCGTGATTGATGCTGAATTTTGGAGCGTATTAAAGCCGCACCATAACTTTAATTGCTTTTCGTTCATCCATTGCCGCGTAACCACCTGGAACACCATCCAGATCGACTGTCAGATCCAACACGGGAGAGGGATCGATCTTCCCCGCAAGCACATCTGCTAACAGTTCCGGAATATAAGCCCGCGCGGGCGCAACACCACCCCGCAAGGTAATATTTGAGAGAAACATCCCTGCCAATTTCACACTGCCATGTGGAACACCGACATAACCAATCGTGTCACCTGGACGTGTAATCTCAATCGCCGTACTGAAAGAAGATTCCGTGCCGACACATTCCAAGACTGCCTCAGCACCCCCTTTAGTCATCTCTTGTACTTCATCAATCGCCTGTTGATCGCGGCTTTTAACTACATCGGTAGCACCAAAGCGACGGGCAATTTCAATGCGTTTTTCATGTTTGCCCAGTAGAATGATTCGAGCGGCTCCCAGTCGTTTTGCTGCTAAAACGCCGCACAGTCCCACTGCCCCATCGCCAACCACTGCCACTGTCGAACCTGCTCGTACTCCAGCAGAAATAGCCGCATGATGTCCAGTTGCCATCACATCTGTGAGCGGCAGAATTGCGGTGAGTAAGGCATCATCGTTTTCAACTTCCCTAGGAATTTTAACTAGTGTGGCATCGGCAAAGGGAGCGCGCACAGCTTCTGCTTGTCCACCATCATTGGTTCCACCCCAAAAGCCACCTTGGATACAGGAAGTTTGTAGACTTTTGCCGCAAAATTCACAGGAGCCATCCGAAAAAGCAAACGGAGCTAATACGCGATCGCCCTTTTTCAAATTCCGCACATCCGAACCAACCGTTTCGACAATACCCATCCATTCGTGACCCGTGCGCCATCCGGGTTTCCAATCATCTGACCCTCGGTAAAACCACAAATCGGAGCCACAGATGCAGGCATGGGTAATCCGCACAACGGCATCAGTTGGTTCTTGAATAGTAGAGTCGGGAACGGTTTCGACTCTTACATCACCAGGAGCGTAATAGACAGTTGCTTTCACAATCGATTTTCCTGTTATAAATAGTTAGAAGCATGGATTTTGTAACTTGCAATTCTTTTCTCTCAAAAGTTTTTAAATACAAGTTTTGAAAATCAATTTTGTACTTGAATCTCATCCACTTTATTTAACTGCTATTTAAGTAGCTTGTAGCTTGATTAATGTTTTTGTTCCAGCCACATTAGTAACTGAAACTGCCATCATCACGCCATTTGAGTTCTGTGCAGTTAAAACTTCAGTTGGTGAATCAATCGTGTGAGCGTAAGTTACTTCATCTCGACCGATTTCAATTAATAAGTCATCCCCTTTCCCCGGTGGGTCATAAACCATCGCCATCAAAGGTGCATTTTTAATCAATTCTTCGTCACCGAGTTCTGAACCGATAATTTCGAGAGAAATATGCCTCCCACGATTCCCATCTGAAAATTGATCGAAAAACTCGCCCCATCGATCCTGTGGTACAGATTTGTTTACGTCGATTTTATTTACCATTATGATTCCTTGTAAAAAATTAGTAATTTATTTGGGTACTTTACTCAGTGCTAAAAGGCAAGAGAAATTTTACTTAGTAGTCCACCAAGTAAACTTTGCGGAGTGATTGAAAATTGGAAACCCAAGAATATGAATCCCTAATTCCCAGCCTTACCCAATAATTTTGGGTTGGGGGACTGCTACTAGTAGCCCACCAAATAGACTTTACCTCGTCTGTAGTTGGGCTTTAGCGCTATGTATCAAAACCAAAGCTCTCCAGCGTGAGATTATTATCCACCGAGAACACCCCTGGAGCAGCCCAGGCTGCTCGTTCAGCTTCCTCAAGTTCACTATAGTTCCGAACTTTCCCACTGAGCACCACCTCATTTTGGGAAGTCTCCACTTGGATCTTGCTAGCATCAAACAAAGCACTTCGTTTGAACGCGGATTGGATAGCTGTTTCAACTGCCATTGTCGTCAGCTTGGGTTTAATCGAGATATTATTAGACACCCCTTTGACACCTGACAGATAATGCACAACGTTTCCGGCTGCATTTTTTTGGTACCACCACTCTACCTGACCATCTAATGTGATCCAGCCTTCACGAACGGTTGGAGTAATGGTTTTTGTTGGGATTATCGTACACGAGGCGATTTGATTTGCAGCAGCGGTAGCGATATCCCCATCTGTGCGGTGCATGGAACTTGGTAGCTTAACTTCGATGTCGTCTGCAATTGCCTTTACCCCAGCAACCCGTTTAACTGCGCGCACGGCTTCCCGTTTCTCGTTATAAGTGGTTGCGTAGCCATTGAGTGTCACGGTTCCATCTTTCACCAAAACACCAATGTCTGTGACCTTTATACTTGGCTCATATTTGAGTTCGGAAAGCACATCAGTCTTTAGTTCTACGTCAGTCTTTTCTATGGTATTTGTCATGTTATTTTTTGTTTACTGGTTGATTAGTGAAACGCAATACTACCTGCTATGATGCCTGAGTTCAAAGCTTTAGACAGCAACTGACATACCCATTTTGTGACCCATTTTGTCTAGCATTTGTTTTACCTGACTGACATCCTCATTGCTGCCTGTCACAAGGATGATGAACTCGCCTGCTTGGATTTGAGTCTCGTACCTCAGTACCTCGTGCTTGGGTATTCCTAACCCTCCTAATGCACCTGCTAGTCCCCCTACAGCAGCAGCACTGGCTCCTCCAATAAGTGTTCCTTCCAACCAGCCCGCCAACACTCCCACAATGGGACCTGCAATGATGAGAGGAGCCATTCCGGGAATAAATAGCACTCCAGCCCCTGCTAAAATACCAAACAAACCTCCGACAAAGCTACCCCAATAAGCACCTCCAGCGGCTCCAGTTTTGGCAGTATCTTTCCAGGTCAAAAATCCGCGCACATGTTCTGTAGTCTGGTAGTCTTTGCCTATGATTGAAAGTTTTTGCATATCGAAACCTTCTTTTTGCAGTTCCAATACAACCCTTTCTGCTTCCACATGAGAGGGAAAATGAGCGACAATTGTATGTGTCATGAGTTTGTTTCCTTTATTCCAAGGTTTATTTTGTAGTCAGATAGATAAGCATCAGATGCTCATCTATCTCAACTAATTCCTGACATGTTTGGTTAAATCATGTCTTACTTATTTTGTAGTTCCCGCAGCAGTTTCTACATCTAATCTGCTACAAATTGCCGATAATGTTGCTTCTTCGGCTTCTTCCATCGCTGCCATTGCTAAGAAGATTGCTGTAGCAGCATAGTCTTCAGCTTTATCTGCCCGATGCTCCAGTTTCTTGACTTTGCGAGTTGCTTTCCATTCCTCAACGTGGGACTTTACTTCAGATTCTTTTTCCTCAAATTGAGTTTTGAGTTTTGCTCGATACTCATCAAATTCTTGTTTTTTAGCTTCTAGCTTTGCCTTCGCTTCATCGAGCTTAGATTGAATCTCTGCTTGAGTTTTTTTCGGTGCAGATTGAACACTTTCCCTTAGAGATTTTGCTCGGTTTTCAATCGCTTCTAAATTGCCGTGAAGTTGTTTTGTGAAGTTATCAATTGTAGTATTGATAAGGCTACCTCTAGGATATTTTGTTTCTAAAATTCACATAAAGCGTCATTAAATTAACAGCCATAAAATTAAATTAGTCTTGACAATTAATTAATTTATTTGACTGATAAAAACTTAAACAACTCTTTCGTAGCTTCATGCTCTGTTTATGTCGATTTTTTACCATCTATCTTAGGTTATAAAGGTGAATATCTTGAGAGGTAGATAAGTAGGTGGGAATAAACACAACTTCTTGGAAACTATTTTTGGAGGCGGAAGCCCCCAAAAAAGTTTCCGCTATGTAACGTAATGTAAATTAGCTTCAAAGTCTTCTTACAAACCCTAACAGGAGGCACAGCCTAGGCTGTTGACTCTGTGACTTTTTCGGGATTTCATTCATTCAAAAAACGTGGATAGTCACGATGGCTGAAAGCTTGATTTTGATAGGGTTTTAGCGAGATATTAAACGCCACGAACAAAAGTACCAAAAATCGCCCAATTTTCAACAAAGTCAACAGCCTAGGCACAGCCACCCCAAATGTTTGCGCTTACCCCTATTACCCCTAATGCCCTTCGACAAGCTCAGGGTAACACCTACTACCTTGTCATAACTACAATTTTCAACACCCACCTATAGCGTTTCCCAAGCAGATGAAGTACACCAATTGTTATCTAAAGCTGATACATAAAAGCATATAGATTTTAATTTGTACCTCACCAGACTGAGAAGCGCTATACTTACATCTGTAATTTGTGACTCTACAAAGGTAATATTTTGCTAATTAATGTATTAAAACTAGCAAGTGTATCCGATTAAAACCTATCCAGCACAGACAATAACATTGGAAGTTGGAAGGCATAAAATTGAGTCGATATCTCCTCATAACCGTCCTTTTCTAACTACCTGTGAATTGTTTGTTTTTAAAGGGAAAGGTAAACTTTTACACCTGTTAGCTGAGAACGAATCGACTCTACCACTTTGTTTAGCTGCACAGGAGACTTGAGAGAGGCTGCCATCTTTTCAGGCAAACGACTGTTACCACTCTGAATACGCATTGGTTGCTGCCTAAGAGTTTGGAGGCGCTGATCATTATTGAAAAATTTATTTCTTGGTGTTCCCTAAGTGTGTCATGTTTAACCATTAGAATGTAGGATAGTAAATCTGTGTTTTCATTGATATACCAGTTAAATCCTATTCCTACTTTGAAATTGAGATATGACATTAATCAAAAAATCGGAACAACAACTTCTGCTTAAAATCAAGAAAATAGAAGATGAAGAACAAAATATTCAACCGGATACTAGGGATATCCCAGAGGTGAGGGAGGAGGAAAAACAGCTAATTACAGAAAATACAGAATCTAACTATATTCCAGCGCGGGATAACCCCATAGTTCAATCCATTGGTAACTCAGGGTGGCAAATTTCGGATATTTGGAGGGATATTCGAGTCGATAACTTTTCTGATTGATAAAGATAAATCGATGTGTTTTTCAACAGCGAAACCTTATTTGCGATTCTGAGATTGGCACATCGTTATACCAAATCTCCAAAATTGCCTTTGAAACTGGTATAAAACCATGTTAAATCTAAACCAAGCTACACCCCTTTTAACACTTTGAACGAATTCACAAAATCATCCAGTCCGAAAAAATCTCAAGCGATTAAAAAGAAGAAAATGTAACAACAAACCCGTCGGAAGAACCGACCCAAGAAAAAACAATTTGGAGTGTATTCTATTATTGCCTACCGCTGAGGGCTGGAGTTAGACACTTTCATCGAGCAGTTTCCACGGTCAAAACCTGGGGTGGTGTGGAATCGGGAGGATAAATAAAATCAACTTCCACTTTCTTTGTCGCACCTGCTGCTAATTGCAACGTCACTAAAGCTTTTCCTTGCTGTCCCCTTCTCTGCACCACATGCAAATATTTTACCTGCATTTTACCTAAGTCATCTTCGTAACTTACCTTCACCGTTCCACGAAAAAATATTTGCTCGACTTGGGGATTTAAAAATAATAATCTATCAGTTCCACCTTCATCTTTGAGGGGAGTTTGGATTAATATATTAACTGTTTTAGTTTGATTTGTCGGGTTATGTAAAGGCAAAGTCAAATCATATTCCACTCCGTAATTACTATGAGCAAAATATGCCGTATCGGGATACCGAGCTAACATCTTGGCACTTTGAATCTGCTTGGTTGCCAGAGTTACTAAATGTACCGTTCCTAGTGGGTAAGAAATAGCTGTACCTGATTCTGGGATGGTTAATTTTGTCGCCTCGGAATTATCAGTAATTACCCCTTCCCACTTTGCACCTTGAGAAACACCAGCAACTCGACCGAATACAGTAGGTTCTCTAGGTGGTTCTAATGGTGTGGGTATGGCATCCCGTTTTTCTGCCAAATTTCCATTATTGAGTAAATTTTGCCACTCAGGTAAAGTTGGGAGACGATTAGCAGTCATGGCTAAATTGGCAATATAAATTACACCGTCACTTTGTAAACGCATCATTGTTGTGCGACCATTGGATGAGGGTGCAAGTACGGGAATTGGTAGATTTGCTAATATTTGGCTTTTACCTGGTTCAATAACGATTTTCTCAGGGAAAATATTTTGTCTCATTCCTTGCAATACATCACCCATTGTCCTGCTTCCTGGTCCCGAATAAACTGTATTTTGGGAATTGTTTTGAATGTCGGGTAAGGGAATAAAGGGAGCTTGTTGAGTTAGATAACTGGCTCCATTTAATATTTCTAAGGTTACTGGTTGATTGCCTGGATTGTGAACAATAATGCCTTGATAAACAGTCCGATTTCTTGCTGCTGTTTCTGCCCTGACAATATGGTGGGAAAAAATATCAAATCTGCCTTGAAAGGGATAATTTAAATGTGCTGCGGGTGTTTTTTTCCCTGATGGGGGAAAGGTTGAGAGTAAAATTCCATCACTTTCCACTAATTCTGGACTGTTGCTGTTGAAAGTGGGTATGGTATCGAGTTTTCCCGGTAATGGCTTTACTTGTTGGGGTTTTACTTCCACTCCAGCGATGTATTGCGGGGGAATGGTGTAGATATTGAGTGCGCGACACATCAATGCGGCAACTTCCCCTCTGGTGGCACTTTGGTTAGGTTTTAGCTGTTTGATGTTGGGATAATTGACGATAATGCTATTAATTGCCGCAGATGCGATCGCATTTTGAGCATAACCAGGAATTTCTGCTGCATCGAGGAAGTATTTTTGTAATGTCTGCGCTGGATTGGAGATGGAATTGTAATTTTTTGCCCCTGTGATGACACCAATAATTTGAGCGCGGGGTATGGCTTGGTTGGGTTGAAATATTCGCCCTGGATATCCTGAGAAAAAGCCTTTTTGGTATGCAGTGGATATGGCTTTATTTGCCCAATGAGTTGGGGGTACATCTCGAAATGGCGTTGAGTTACGTTTGTTAGGGGTGTCAGGAAAAGCGTTGAGCATCAATACTGCTGCTTCTGCCCTTGTGACTGTGAGATTGGGACGAAAGGTGTTATCAGGGTATCCGGTAATTAATTTACGGGAATTTAGTTCGCGGATGCAATTATTTCCCCAGTATTCTTGCGTGTCGTTGAATGCCAGGGCTGTAGTGTTCGGGAAAATTACAATGATGCTAGAAAGGGTCAGAAGTCGCAGTAATGATGGCATGGGCAATTGGATTGATGAGAATCAAGTTTTCAGTAGTTAAGCAAATATAGGAAGTAGTTTATATTATTGTTGCTGGTTTGCGTTAATGTACTTTCAGAAGCAGCCAGCCATTGATGAAAATGCTCTTTATTCCAGAATTACTGACTTTAAATTATACAAGATAATGGTAGTGCGCGTCAGACATTTATGTGAACAAAACAATCCGCGAAGTGCAGTTTTATCTTACTAGTTTGAATTGCGATGCGAACAAATTAGACCAAGCTATTCGCCTCCATTGGAGCGTTGAAAACGGTTTGCATTGGACATTGGATGTTACCTTCAATCTATTTATCATTAATGAAGTACAATCCTCTGTCAAATTCATAAAGTGATCTGTATATTTTTGCGGACAAACAGAGCTGACAGCGCAGGAATAATTTTCTCACAAGCCATCAAAGCACCCTATAAATTTCGTGCAGTTGGTCCAATGGTGGTATTGTCTCGACCATCCCGAAGTTCCTCCTGATAATAATTTAGCCGAACGGTCATTACGGTTAGCTGTCACTAAACGAAAAATTAGTGGTGGTTCCCGTTCTCTTGACAGATTTGGCGATACTGCAAATCTATTAACTGTTGTCCAAACTTGTAGAAGTCAGGGACGTTCTGTTATTGACTTTTTTGCGAGCGCAATACAAGCTCATACTCGCAATCAAATTATTGCCCCCTCCCTTATTCCTTCTTCTGCTACCTGAATCCTTACGAAATAGGATGATTGTTCAGTTAGTTCAAGATATTCTATGCTAATTTTGGAGATATCAAAACCTCAACTAGCTGGGAATTAGCAAATAAAATGCTTCAAAGTTACGAAGCCATTATTGAAAACGGTCAAGTTAAGTGGTTAACAGATGCGCCAAAAGTATCCAAAGCGAGAGTAATTGTGACAATTCTCCCGGATACGGTAGCGCGAGACTCGACAGGAGTCGCTACGCGAACGCAAGGTCGAGTTCCTGCAAGCACCATTGCCGGGAAAGGTAAAACCCTGGGGGATTTAGTCAGCCCAATTGTCTCAGAACAGGATTGGGAATGTCTCAAATAATCGTCCTCGATACGCATATTTGGATATGGTTTATCAATCAAGAGTTTGAGCGGTTTCCAGCCCATTGGCGAGAAATTATCGAAACTGCTGAGATTGTTGGGATTTCACCAGTATCCTGCTACGAGGTTGCTTTAGCACAACAACGCTTAAGGCTAGAATTACCATGTGTTGTTGATGAGTGGTTACGAGAAGCTTTGGAGCCGTCTGGTGTTACATTATTCCCAATAACTGCTGAAATTTCATGTAAGGCAGTTAGTTTATCTGCTGTCCACAAAGACCCTTTCGACAGGTTGATGATTGCCACAACACTAGTTTATCAAGCGAAGCTAGCCAGTATAGATAGCTTGTTTTCGCAATATTCGGAACTTGATGGGTATTTAATGAATTAGTGAGGACTTACGCAAGGACTACGCAGTTACGTCATTGCGACGCAAGGAAGCAATCTCAAAGTCTTGTTTTCTCGTTACGATTGCGTAAGTCCTATTAGTAATTCTTGGTTTGGATGTTCGATATTATTCTCTTCCAAAACCGTAGAACGCAAATTTTGCCAATATTCTGAAGTTACTTCCTGTCCTGGGGAATTGATACCTTCGAGTAAAAGAGTCTCTAGTTTTGCTTGTGCTTTGCGTTTTCGATCTTGCTGTACTAAATCTAAAAAATCTCGCAAATATTATTGTACGCTCCTGCTGTTATTTGTGTTTCAAGATAAACGCGCATCTCATCAGTTAAACGACGACGATAAAATTAATACATAGGTTCCGCCCTATGAGCATTCGTATTATTGGGCAAGTTTTATTATTACTGGTGGGGTAAATCCTTGATTTTTAGGAATGATTCAAATTATTTTTCATATTTTCTTTAACTAAACTCATTAAAAAAATATAAATCGCCTCATTGATACTGATATGGAATCGCTACGATTGATTTTAGAGATAACACGTATATTGATTTCAGTATTATGATTAAGCGGCTTTGGCGGTGGTTAGAAAAATTTTACGACGCTTATTTGTCTCTTCGCCTCAGCAGCCTGTTGTCAAGGAACTTTCAGTTGTTAGCTGAGGTCAACGACGAAGATTGGAGTCACGGACGGGTCAAGGGTTTTTTAGATGGCAAAAATATTGCTGAAGCTGATTTATTGCAATGGTTGCGGCGTTCTGGTGAGAATTTGCTAGCTAGTGATGGGGAAAATCGGGAGTTGGCAACGCGGATGGTGCGGTTGGGTGAGGTTGATTGTGGGGAGCTGGGTGAGATTGCATCTGAGATTGGGAGGAAATTGTTGGGGAAATGCATAGAAGAGGAAACAAACAAAGAAAAAGCGCTATTGAGTAAAAACGGCACGTCAGGAAAAAAAGGTATCTTGAAAACGCCTGAAATAGTCAGTAAACTCAATGCCAACAGGCTTTAAGTGCCAATTATACCTAATAGCGAAAAAGCACCTAATTCTCATCAATATTGGTACAATCGGGGTTTGGCGCTGCATTATTTAGGACGGTACGAAGAAGCGATCGAATCCTACGATCTGACTTTTCCCGTTAAGTCTCTTTTGCAAGCTGCCAACCCTCACAAAGGTCGTGCAATTTTGACAAAACTGCTGTCAGGTTAGATAGACTATTGAGGTGGTAGAGGTATCGGTAAGAGGGTAGGTGGATTTTTGGATTTGGTATTATCTTCTTCATCTTCGGGAACTGAACCAGGTGCAGCGTTGATGTTTGCTGCATTTGCTGGGGTGTTTTTTTCGGTATTGGCAGCTTTTGCTGCTGCTTCTTTTTGGTCAGCTTGAGCAGATTCTGCTGCTTCTTTCTGAGATTTACTAATTGCTTCTGCCATTTTTTCTGCGGCAACTATTGCTGGGTCCTTTGCCTTGGGGTCATATGTTTCTAAAATAAGCGATCGCACAATTTGTTGACCTGTTGTGGTGGTAACTTGTAGTGAGATGGGAATACTTGCTGGTTTGGGTTCGAGGGGGAAGGAGATGGAGTCTTTGAGACGGACTGTTCCGGGTGCTGGTTGTAATTCGACTTTTGTACCTTCACTTGCATCAATTTCCCAAGAGAGGACGATTTTGGGAACTGGTTTACCTGGGGTGATGGGAACCATTAATTTTGTAGGTGCAGGTTTGCCGTTAATTTTGAAGCTGATGATTTGGGGTGGTTTGGGAATAATTTTAATTAGTTCGGTTTTGCTGGGTTCTAGTTTTTGGTTTTCGCTGTCCTGGGAAATTGCTTTGAGTTCAAAGATGTAATCCCCTGGCTTTTTGAGGTTGGTTGTCATGTTAAAACAAACTAGGGGTTCTCCAGCAGCACAGAATTTTTTTAACTGAGATGGAATACCTTGACTAAAGTCGAAGTTTTTGACGGGGGTAACTGCTAATCCATCAGGTGTGCGACCGATTAACTGTACCATTCGTAGTTGACTTGCATTACGAATTGCCCAGTTAAGACGAATTTGAAAGTCTTTATTTAGAGATTTGGGATTATTTTTAGCTTCTTTTTGGTTGGGATTGAGGAGACTAAATTCTTGGTAGGTTGGTTGGGTGGAACCAAAAGCGATAATTTCCGGTTGGGGAATCGGTGCGATCGCAACTGGATTAGTTTTGATGTTGTCGGTGGCTGCTCCTCGTCCGGGTTTGGGTTGGGTACTCATTTCAAAGATGTAAGTACCGGGTTTACGCGCACCTGTGCGAACATTTCGACAGTTTAAAAGATTTTTTTGTTGGGTGCAGAAGGATTGTAATGTTGCTGGTACTCCTTGGCTAAAGTCATATTCTTGGGGACGGGTGAGGGGTTTGCCGTCTGCTGAGATACCAACTATTTTTAAGGATTTTAAGCGGTTGATGTCGCTAATTTCAAATCCCAGACTGACTGTATCAGCGTTAATGGCTGCGTAAGCGCTATCTTCGGGGTAAAATTGCCAGATTTTGGGTGAGGGGGGAATTCTAAAGAGAAACCACCAAATAAAGTAAGCGCTTGTACCCAGACATAGGAGCATCAATAATATCAATGGCAGTATTTGCCACCAAGGACGTGCTTCCCACAAGAGCATTCCGGGGAAATTATTGGGTGCTAGGGGTAGTTCTTGGTGATCGAATAAATCGATGTTAAAGTTGACTATTCTGGGACCACCAATAAAGGGACGTTGCCAGCGATTTTTTGGTTTTATCTGCAAGTCAACTGCGACTGTTTGCTGAGGTAAAATCAGAGCTTGAGATTGTTCTAAGGTATAGTTGCAGATGTGATTTTCTTCTAATTCCTGAACTTTGACGTTTATTTTTCGCGGTGTGTTACCTGTATTGGTTAATCGCAGTTGGTAAATTCCTGTTTTGGATTTAACCCGACTAATAATCGATCGCAGTTCGGTTTGTAATTGGTAGGTGGGTGCAACTTCTAGATAAAGCAAGTCTAGTAACTTCAATTCCGGGTTATTCTCCGAATGCAGACGCATTGTGGGAATATATTTACCTGCAAGGGTGCTGATTGGGGGATTAATTAATAGAGAAATTTGTCCGTTTTCACCTGGGTTGAGATTGAGACAATCAGTTTCAATGATTAATCCTGTACCTTGGAAAACTTGTGGATAGGTGATATTCACCCAATTTTTGGGCAGATCTGTACAAATAAGGCGAAATTTATCAACGCGATCGCCTCTATTTTGCACTAAAATCTGAACTGCTAGCGCTCCTCCTGGTTGAATAATTGATGGACTATCTGGAGAAGTGGTTGGGTATGAAATAAATGTGGGGTCACTAGAATTAATAATATCGGCAGTGGCTGGAACAATTTGCAGATATTGTTGGTATTGAATGGGCGTATACTCTGGGTAATCGTCGGGAGCATCAACTACAACGATATAGTTGTAAAGTCCTGGCAGGGTATCTATAGGTATATCAAATTCAAAGATCACCTCTTCACTGCGATCGCTTCCCAATGCCAAGAGCTTTTGTCCTGACTTACACCACTGTCGTAGTCCTTTTGATTCTTCTTGAATATAAACTTCAATGACAGCGCTTTGATTACCTTTATTTGTCACCATCATGCTGAGGTGAAAGGTTGAACCAGGTGTCACATTATCTTGACCGGAAGCGCTAATAATTACAGCTAATGGTTTAATCGCTAAATTTTGTAAGCGATCGGTTGTATCGAAGTTGAAAGTTGAAAGTGCGGAGTTTAAGTTATTGTTGACCATTGGGAGATGGGGGAGAGAGGGAGGATGGGGGAGATGGGGGGGAGAGGGAGGATGGGGGAGATGAGGAAGATTGCGAGGAGGCATCTTTTCAATACTTCCCACACTTACCTTCTGCAAATTTATTGACAACTGGAAATTGCTTTTGTGACACGATGTAATCTAACTTGCGGGTCATCACCAGCAGTAGTAATTAATAATTGATTGCGATCGCGGTTTAGATCTATGCTCTTTAATGGCTTTGATGATTGATAAATCACTTGACCATCACCTCTGCGTTCTCCTTTACTATTTAATGACCATAAAATCGCTTGACCGTTGTCTCCTGCACTAGCTAAATAACAACCATCGGAACTAAAAGCTACAGACCGAATTGCTTGTTTGTCGAGAACCCATTCTTCGATTAATTCACAATTATCTTTTCCTGTGAGGCAAGAACGCAAATTCCAAGTTTTTATACTACCTTGATTATCGGCAGTTGCTATCATGTAGGGCTTTTTATCGACAGTAGCAATACTATTTATGTAATTTTCTTGACTATCAACACCGTAATTTTTCATAGGCTGAAGTTGGTTATTTTTCAGATTCCACAGGGTAAGTTGATTAAATCTACCTGCGATCGCAACATGATTTTCATCTGGTCCCACTAGTGCTAAAGTATTAACCGCAAATCCAACTTGTATGGAACGCTGTATGCGTTGATTTAGGGGAATTCCATCTTGAATGTTCCATTGCCATACCATACCGCTACCATGACCACTAAACAGAGAACGGGAATCTTTGGTAAATACTAAGTCGAATACTCGGTCATCTTTCTGGTTGTTACTACTCAAAGGTAAAGAAACTTCACCTGATAATAAATTTACCAGTTGAATTTCACCATTTTCAAAACCAATTGCAATTTGGTCGTTATTTACTGGACGGTAACGTACAACTCGTACCGCTTTATCTGCACGTAGCAATACATCCAAAGGACGCAAATTATTATCTTGTACTAACCAACGTCGAATAGTTTGGTCGTTGGAACCACTTACGGCTTCCCTTCCCAGTCCACTTAAACGCAGCGAATTCACTGGTTGACTGTGTTGTTGTTCTAGCCAAAATGAACGATTCACAATTGTGGAACCGATTAAAAACCCTAATAAAAGTCCTCCTAACTGCAACCATAGGGGTAACATTGGAGGAACAGCTAATTCCAGGGTTTGAGTATCGTTGCGAACTTCAATGCGATCGTCTGAAGTTATTGCTTGTGCTTGGATGTATTTTAGTTTAGTCCAACCAAACCAAGGTCGTTTATGCTGCACCTTGAAGTTAAAATTTGTTGGTTTGTTCAAACTTAAATTAGCTTGTTCGGGGAAAATTTCCCATGTCAAGGAACTATTTTGCTTTTCTTTTGCTTCAGTCTCTAAAATATTTTCCTGATTTTGCTTCTTTTTTGTATCCCCAAACTTAAACCAAAATGGAAACTTGAGGTTTTTTTTATCTAATGCTTCTAAGTCAATGACTTTAATAGTTGTTTCTTGGCAAAGATTACTTTGATTGTCAAATTCCAAGGAAAATTCTTGAATAGCTAAATATTGCTTCCAAAACAACCAACGATTTTTCTTGGGTAATTCCACATCAGCAAGCGAAGGAATTGTTTTTTTACAATTAAAATCTACATAACCTCGTGGTAATACCTTGACAACACCATCAACCCGAACCGCAGTAGTATCTAACTGAGAAGCTTCGATTGTAAAATCGTAATGTTTACTTTCTGCAAGTATGAAATCGTTAGGTATTTGGCACTCAAATACTTCTCTAATTTTACTACCACCTGGAAGTCTTAAATCCCTTTCTCTACCTTTAGGAAACCAAGATAAATCTAAACCATTTAAACGCAGAGTAATCTTACTTGCTTTTTGACTCAAGCTTTCTATGGAAATGGGTATTTGAAAAACTTCACCAGGATAGCGATTAAATTCTTGACTAAGTAATTCGATTTGTGGTGCAGGAATTCCATCACCAGGAATTAATAGTCTAATTACCTGACGACTTTCTTCTGATGGGGGTAATTCTAAAGAAAATACCCTGACAGTCAAAGTCATTACCCCAGCAAACCCACGTTTGGGAATATCAATTATCCTAATAGTAAATGTTGTTGAATCTCCAGGTGGTTTTTTAGTACAAACATCTGGAGATATTCTGTACCAATCATCGCTAATATTTCCCTTTGCAATATCAGCGAGTAGTTCTACCTGAAATGTTGCAAAACCATCACTATTGTTAATGACTGTTACATCAAAAGATACTCCCCCTAGTTTAAATTCCAGTTGATTAGTATCGATTTTGGTTAAAATTTTCTCTTTAGATTTTAGCATTTATTTATTATCTATTAGTTTTTATTAGCTCTTATTAGTCCTTAGTTATTTTCCAATACGGTTCAGTTAAGCAAAAATTGCTATTAGCTATTAGCTGTTAGTTATTAGCTTTTAGAATCAATAGCGTATAGAACATCAGTCTTATTCTTACCTTCTTCCTCCTTAACTGAACCGTATTGAGTTATTTTGTCCTTTCCCTATTTCCTCCGAATTAAATCTTATCCCTAGCTTTTTGCGATCGCGCTAATAATTCTTGTACATTTGACTGTTTGGCTAACGTCGCTTTATTCGCTCTATCTGCTAATTGATTCACTTTGTTTTTTAAGTCAACCTCCCGTTCATATACTTCTTGTGCCATTTTTTGAAATATATCTGCTAATTCTCCTAATTCATCTGAACGTTTAGTAATAGGTTCAAGAGTTATTTTCAAACTTGCCAAATCAAATTCCTCAGAAGTAATTTTTTCAGCGGCATGGCTAAGTCCCAAAATTGGTTTAGCTAACCAGCGTGTCACTAAAACTCCTAAAAACAAACTCAACACCACAACACCAAATGCCATGACAATAGCAAAGATTCTTACCCTATTTACATCTTGCATAAATTCCTTTTCTGGTACAACTATCACTACTAGCCAATTTAGACCTTTGTATTGTTTGTCATCATCAAAAAACTTGGTAATTTTCACTAGCTTTAATTCGCGATCAGGTGAATAAAATTTAAAGTGTTTTTGTCCAGGAATATTAGCAAAACCACCTGGAATTGTTTTTTCTATATACTCAGATGTTGCTTTAATTAAAGGTTCTTGATTAAAATCTTTTGCTGAAAACTGATTGCCTTTGTCATCAAATACTTGTATTTTTGTAGAAGCTGCAATTAATTTGCCATTAGGCTCAACAATAAAAATTTCTCTAGAAGTGTTCTTGGTGATTTCAACTAAAAAATCACTAATTTGATTCAAAAAAAAGTCTACAGACCAAACTCCCAAAAGTTTACCATTTTTTCGTTCGTAAACAGGTTGCACTGCTGATAAACGGAGTTGAGTATTTTTAGTAGTTTTCTTCGGAAAAACTGGTGTCCAAATTGCTTTACGAGCTTCAATAGCTATCTTGTACCATTCACGTTTGCGAGCATCATACTTTGAAATTCTACTTATTTCTTTGGCTCTATCTCCTTTGTCATTAGTTGAGAAAACAACAGCATCCATATTGGTAGAAGAATCAGCAATATTATATGAAAGTTCTCCTTTTTTTTCTTCTCGGACAACACTGTATAATTCTCCATTAAATTCAGAGCCAAACTGAATACCATTAACCTCCTTAAATGCTTGAATTTGATGCCATAATAATATCTCCATATTTTTATTTTTTTGTAAATCTAACTGCCCTATCTCTACTGCATCAGTATTAATTTGATTAATGATATGGGGTAAATCAAGAAAATTATTCAGTCTTTGTTTAATTTGCTCGCTAAGTATTTCCATACTTTGCTGGGAAAATTTTCCAGCTATTTTTTGTCCTGTTAAGACAGCTGTGACTCCCAACAGTCCTACACATGTTAATAAGGGAACGAGAAAAGCAATAGGAAGAGTTTTACTAAGAGAAAGTTTAGGCATATTTTTAAGGTAATGGTTAGGAATTTAAGATTTATGAATTAATAATTTTAATTGAGTCAGTAAATTTATTGGGTTTTATATATTTTTTAATTTTCCTCTTTATTTTTTTTATCTTTTGAAAATTCTACCTTTTCTCTTGCTTGTTGAGAACGTTCCAGCAAGCTTTGTAAATCTGTATTAATTCCATCTTTTGGAGTAACTAAAGCAGTTTTTTTGGCACTATCGGTTTCATTACGAAGTTGTTGCACTAATTTTTGTAGAGATTCTTCTCTTTCTAATACAACGTTAGTCATTTTCCTAAAAAGTACTGCTAACTGACCTAATTCATCAGACCGCTTGGCAACTTTATCTAATTTCTTTAAATCTGATGCTTCTGTTTTTTCTGAACCAACATCAGCATTACTTATTTTTTGAGCAATCCTAGCAATAGGTCTGAGAGGAAGAATTACAGTGTGTTTGAGCAAAACATTAATTAAAATAACTAAAATTGCAAAAATTACAGTAAATATTCCCACACTTAATACAAGTTGTTGCTGATAGCTTTCAAATATTTCTTCAATAGTTATATAGACTGTTTGAGCAGCTACTACTTCATTTTTTTTCCAACCAAAACCATGCTCGGAACCATAAGTATTAATTTGACTTTTTGGAGCTAAGTTTGGTGAACTATGACAGCGCAAACAACTATCTTTACTGATAATCAGAGGACGAGCAACATAAAATAAATTATCTTCAGATCTTTTACGAAAACCTGAAACTTCTTTTAGAGATAAATCCTGACGAAATCTTTGAACTATATCCGCTTCAAAATTGTCAGCTTTGTCACGTAAATTAGTCGGATTTAAAGTAGCTTCCTTATAAAAAAAATCCTTATAATTCGGACTTCTGCGTAAATTTTCAAAAACCTGCCGTGCAGAATAAGCTGGTATAGTTTCCGGAATAAACTTGGATTCTATTTCCCATCTATCGGATAATAGAGGTTGAATTTGATTAGTTGTATAATCTCTAACTGAATTCATCGTCTCCATTAAAATGAAAGCCTTGTTTGCTACCTGTTGTTCGGCTTTCTGTTGTGCAGTTTGCGATAATAAAAATCCGCTTAAACAAATACCAATAATAAAAACTATCCCTAATATAAAAGTAAATTTTAATCCCAGTTTAAATCGTTGTAACATCTTAAATTACTCTTTATATTTCCGCATATTAGTCATGTTTTATTGCTGGAACTCTATTGCTTGGGCTACAAGTAACATTTTAGTTGTACCTACTATTTAGTTGTTCTCTTAATTTCCTCTTTTTCTTGATTTTTAATTTTAAATTAGTTTACAACCTTGCACCTTTCTCTACTTTTGAGACTGTATCAATTGATGTCGATACCAAGCAAAATGTAAAATATTAATCCCCATTTCTTGAGTCGTACGAATTATTTCTCTCGAAAGAGATAAATTTTCATCAATTCCCCAACCACTAGAAAGCGAACCAAAAATTAATATAATTCCTCCCCAATTAAATAAATGAATGGGATAATTTTTGATTGTTGGCATTTGTGAAAATAGAAAAGGTTCTTTCCGTAGAGGATGATGAGATGGGAGAGTAGCGAAATTAGTAATGGGAATACCAAATTGTTTTGATAATTCCTGAATTGGTTGTTGAATTTGATATAACTGCTGCTGGAGTTTTTCCTCAACTCTCATTAATTCTGCTTCTAATTCTTGACTAATCAAAGCACTTTCTTGCTCTTGAGTGAGATTTGCGATCGCACTCCGCAATTGTTGCCTAACAAAGCTCAATTCTTCTACTAATGCTTCTTCCACTTCGATGAATATATTTGCACCACTTTGTAGATATTGCTGCAAATTCTGAACTTGTTCTTCGTCAACTTTCAGACTCAAAAATTGCTCGTAGGTTAAATAAAGCAAATCGCTATCTAACTTATTTACCGTCTCTGACAAGCTACTTACTTCTATAGCTTTTCCTCCCATTGCGGGGTATAAAGCTGTCATCGACTGCAATAAATAAGTCAAATTCTCTACAATTTTAGGATTTGTTTTTTGCAAATCTGCTAAATATGTAACTACTACTTGTTTTTGGATACGTAATTGTGCACAATTACGAGAGCGTAAATCCAGGTTATTTATACCGGGTTGTAGTACATCAGGTGCATTGACTAACTCAACTTCACCAGGTGTAAGCAAAATCCGACATAATTCTACCTCCGTACCATTGGGAGGAGTGGTCTTTTCATCAATGCGAAAAGTTTCCTGAACAAATTGCCGATCGCTTTGATTTTGTAATTTATCTGGGTCTACATAATTAACTATCACGTATACTGTTAAGGAACCTTTTGCAGGTGCTTCGGAAGCAATCCGAAAAGCTAAAGCTTGGGGAACTATAATTGGATTCCCTTTACCATCAATTGCTAAACCTGGTTGAATTTGCAACCATCGTCTATCTTTATATTGTCCGGCAACCTCTTCAGGTGCATCAATAACATGAACTCCTAAACCCCACACAATTCCTGCTTGGTGCAATGATTGATAATAAATATTCTGACGCTGACGGTGGTAGTCATGAGCTTGTTTCCAAAGATTTGCTGTGAGGAGCAAACCGTCGGTAACTTGGAGTCTTTGTAAAGGTTCAATTGATATCATAAATTAAGAAAATATGGGAAAAGGGGAAGGGGGAATGGGAAATGTGGGAAAAGATTTTAATTTTATATTTTAAGTAGTTGTGCAAAATTAATTGTACATTCCGGAAAGTTGAAGTTATTGGGTGCGCGGAGCGTGTCCGTTTAGGACTTATGCTTCCTTCCGAAGACGCAAGCTACGCAATGACAATATATATTTAATTTTGCGTAAGTACTTATTATTTATTTACCCTTTAATCCTTCCCCCTTTACCTTTCTGTTGATTGGATATATAAATCATAGGTACAAAATGCAGGTTTTTCTTGCTCAATAATATTTTTAACTAAAAAATCATCAATTTCACTCTGGTGATTGGGACGGAGAATAATGGTAAAATGAAATGGACACCCACCACCAACTATGCTACTTTCACCTATTAGAGTTTCTCCAAATACGAACCCTCTAGAGAAAGATTCAGTAATACTAATATGTTTTTCTTCCTCATTCAAAATATCTTCATCTAAAGGTAATTGTGTCACTAAATGTAGAAAAAAACGTAGTCCTCTTCTTGTACCACGCCAACGAAATATTTCAATTGCACTTTTAATTAAATACCGTTCTTTTTCTGGCGAAATTTGCGGTAAATGTTTCCATCCAACCCAATAAGAAAGAAAGGGTAAAAATGCAGTTGGTGCTGTTAAAGGATTAAGATAAGCCGAAATATTTTCCACAGTATGAACGCAAGGTTCAAAGCTTTGTTCAAATATCTTTAAAAATCGTCCAATAAAATCAACATCTCGATAAATTCCTGGGAGAAAATCTAAATAAAGACTTGGTGGACGCACATAAAGATTAAAATCAATGCATTCAACCTGATTTTTTCCAGAGTCTGACTCCATTGAATATGCATAGAGATGTCCTTGATAATTAAGTTTAAGACTTTCTCCTGGTTGCAGTGCGGTTGGTGATTCAAAAAAATCATTAGATATCTGAAAATATAACACCGCTTCCATCTCCGTACCTGGAAGTATATCTAATCCTTCCATCCCAATTCGACACCAATTTGCCGGAAAATCACCCTGTACTTTCAACTCCAACTGTAGGGGACGATTTCCTAAATTCTTCACCTGCACAACCATCTCACTTGCTTCTCCAGGACGTAATTGCAAGCTAATTTGACGACTTGCGATCGCAGATGTAGATGCCTTGATTCCTACCCCATAACCCGATTGTGTCCCTTGTTTAGAAGGAACTGCATCAGGTATCTGCATTGGTGTCAGTCGTACATCGATCAGTTGACTAGATTGGGATTGTGTCATAAGTCATAAATGGGGAAGGGGGAATGGGGAGGAAATTTTTCTTTTTCCCTTAATTTTCTAAATCACGGTAATTGCATGACTAGATCGCAATTGATTGTTACTCCAAGAGCAAATTAATCCGAACTCTCCAGGATTGATTACACCTCCATCTGCTAAAGCACGAGTCCATTCTGAACCATGTTGATGTAGTTCAAATAAAAGAATTGCACCTAAAAAACGAACTCCTGTTGTTTTCTGAAACAAGCTGATAATATCTGAAGTATATAAACTAGCTCCAAATTGCCAACCTTTGCCATCAATTCCACCAGTCAGGGGATTGAGGAAACGGTACAAAGCTATTTGTAAACTTTGAATAATTGTTTGTTGGGCTTGAGAATTGTTGTATTCTGGCTCTAACCCAACTTCTGCTTGCACTGAAACACCAACATATTTAGGTTCACTCAGTCTGACCTCTATACCTAGTAAGCGTCTTTCATCTAAATAACTCAAGATGTGTTGCTGCAAAGCGGTATTAAGCATAAATTCACCGGGATGAATACCTTCTCCCCGATTCACACCTTCAATATTTGCTTGGGGAACAACCAATAAATCAACGACACCTCTATTACTCTTATCATTCATCCGTCGAGGACAATAAACACGAGCTACTGCTCCACCTCCTGCTTGCAATGCCAAAGTTTCAAAGTCTTCTGGAGTCACAGCGCGATCGCGTGTTCGTAAAATACTAGGAACTCGCATAACTGCATTGTCCAAAGACTCTGCATCAGCACCATTACGAGCAGAAATGTGATTTGTCACCCTTTCCACATAGGGAATTGCCGTCTTGGGAATTTGCAATGTATCTCTTTGGACATTGCCTTGCTGCCCTCCACCAGTGCGGTATGCAACCATACGAATCTGGGAACCCTTAGAAGGTATTGCTCCATACTGCCTTTCCATATCTGTGACTGCTTGCAAAGCATCCTTTAGTTGCAGTGTATTTACGCCACTAACCTGTATTTTTGACCGTAATTCTACTTGAGAACGAATTTGAGCAGGTTCGCGGATCAGAAAGCCAAATTGCACCTCTCCAGTTACAGAATCAATGGTGTAATGTTTATCATTTGCTTTTGAATCAGCAAAATCATTAACCTCCTGCCAAATCTCCGGTAATCCTGCTGGTGGTAATACTAAAATGTACTCACCTTCCTGCCGTGGCAAAATCGAAGTATTCTGTAATTGAAACTTTTGCCCCGGATTTCCATTGCTAATTCCTAGCACTTCATCCCGCACCAAAGTACAATGACTAGCGCTCACAGTGCCACCAATAGACCGTACTTGTATCCCTAGTAATTGCGGAGAAGCTGTGTATCGAGAATTACTATTAATCTGGCGATCGTAAACGCAACGCACCCATCGTCCTTGATAGCTACTAAAGTAAGTAATTGGAAATACTCGTGGTAAATGCAGGACTACATCAGCTTCACCAAGGGTATTCATCCCCAATTGTGAACCATCGCTAAAACTAAAACCGCGAGTACCATCGTCAGATTCTTGGAGTAAAATTTGCTGCCAGTGTTGACCATTCCAAGCTTCCCAACGACGGGGGGGAAAATCGGGATTTATACCAGTTGAGGAAGCAGATTCCCCTCGCAATTTCACAGCTAAGACATTACCAGCAATTGGTTCATCAGGATTAAAAACTAAATAAAAGCAATTTCCGATTTCTGGTGACTCAGCAAAAATTGGTTGCGCTCGTCCTTCCCAACTACCATCTTGGCTTTGCGTCCACATATTAGTTAAGCGATCGCGTAAAATTTTTGGCTCTATTTCATCTGTCGAACCAGTGAGAAAATGACATATTTTTGGCTTACCTATTAGCAAAGGTTCGTCAGTACTAAAAACTACTGCCTCTACCGTTTCTGTACGTAAAGTTGCCACCTCTGTACCAGGAGGAATTTCGTAGGTTTTAGGTAAAGTCGCACTCAAGTAAAAAGTTAATTCCGTCTTTGCAGGAGCAGCAGCTAATAACCGAATCCCCAACATTTCCAAAAACACCACAAAATTGCGACGTGGTACTTGATTAAACCGCAGTAGCATCTGGTCAGTTAGCCAAGCAAACAACTCAACCATCGTGATACCAGGATCACCAGGGTTGTAATTAGTCCACTCTGGACAGTAACGGGGAATGCGGAGAATGCACTCCTCCACTAAATCTTTAAACGTGCGATCGTCTAAATCTGATTTGGGTAGTTTGGGTAGGAAGTCGAAGTCCATAGGTGTGGGAAATATGGGGAATGGGGAATGGGGAATGGGGGGGGAAATCTTTGTATATTCTACCTTTCTGCTCCTTTTCCCCCTTCCCCTTTAACCGAGTTGTATTGGGGGGAGCGGTTGATCGCTTGGATTTAATTGGAGAGCATACGACTTAAATCTATTGCTTGACTATAAAGTTGTGTGTAAGTGCGATCGTCTAAATAACCGACTTCTAAAGCTACTCTTACGAGACTGCGACATTCTCCTGCTGAACCTTTGGCTATATTCAAAAAATTTACATACTCTTTACGAGAATATCTTTCAAAACCCTCTGCTATATTCGTGGGAATTGACACAGAAGCGCGTCTTAATTGGTCTTTTAAAGCAAAATCCTTACTGATTTCACCTTCCTTAGTTAATAAATATATTTCTTTGACTAGCTCAATTCCTTGTTGCCAAACTCTTAAATCTTCAAAACTTTCTATTTTATTTTTTTCTATCTTTTTTTCTGTCTTGTTGTTCTCCATCTAATTTTTTTCCTCTAATTATGTTCTTCACATTTTCCCCATTCACCCTTCCCCCTTCCCCGTCTTCAACTTCCTGGCATTAAATAAAATGGAAAAACCAGACTGCGTTGTTCGTGGCTGTTTCGGGGGTGATATTCAATAATCACGTCTAATCGACCACGTACCGGATCAGGTTCAGCACGAACTGCATCCACTACTATGCGGGGTTCCCACTTTTCCAAAGCTTCCTGAGTATAAAGTCTTGCCAAAAGCAAAGTCTGGGTATTCATCGGTGCAAATGCCAACTCCCCCAGACGGGAACCAAAATCAGGTCGGTATACTCTTTCTCCTAAATGGGTACGTAAAATAATTCCTATAGATTCTTCAATATTTTGATTTTTGGGACTGATTTGCATGTTCCCTTGCATAGTCACATTCAGAGGAAACGCCAGCCCTTGACCTAGATGGTTTTTGTTTGTATCTAACATAGGATTTTAGGTTCCCCTCAAAGATTCATGCCTTAACAGGATTTCCGTAAAAACAACACCAGTATACTGACCTTTGCTTAAGAGTGATATCAGTAAATATTCGGCTATATCGACAGAAATACTTAGGAAAATAAAAAGTATTTAAGTATTTACCCTATAGTAAAATTACTGACAATCATCTATTGTGGCTGTTTTTCTCAGGGATTACTCGGAAAATCAAAGCTTAAAATCATCTTCCATAACAAAAAATCTGCCAGATGGTAAGTAAAGATGAAGAAAAATAAATTACAAAATACTTATCATTACTGACCTGTAAATACCCAGAGGCTGTGCCAAACTGGAGCAATAATAATTTTTACATCGGAATACGTAATTTTATGGCAAAGCAGGAACAGCTTCAAAAGAAACCTTCAACAACTGTATCTGAACCACAAAATTCTTCTGAGTTCCTGCAAACTAGACCTTTTGCAACCAGCGAACAAACTACGCAACCCAATTTACAGGCAAAGAGCGATACCAACCCTGCGGGAACTGCAAGGCAGAACAAAGATGGTCGCCAAGAGCATCGCACTTCTGATTTTGGTCACAGTTTTGGAAATTTAGCAGTTTCCCCTTCTACAACTTCGGTTCAACCTAAATTAACTATTGGGCAACCGGGGGATAAATATGAGCAAGAAGCGGATAGCGTAGCAGCAGATGTGGTACAGCGCATAAATCAACCACAAGCAGCATCTTCCAAGCAGGAAGAGACGGTACAACGTCAGGAAGTACCAGAAGAGGAAGAATTACAAATGAAACCTCTGGCTGATTCCATTCAGCGTCAGGAAGTACCACAAGAGGAAGAATTACAAATGAAACCTCTGGCTGATTCCATTCAACGTCAGGAAGTACCAGAAGAGGAAGAACTGCAAATGAAACCTTTGGCTGATTCCATTCAACGTCAGGAAATACCCGAAGAGGAAGAAATACAAACAAAATCTTTGTTACAAAGAAAGACAAATAACGAAAATCAAACTGCTCCCGATAGCATTGAAACATCAATTAACCAAGCACGAGGTAGTGGACAATCTCTGGGAGATGTTCAAGGGAGCATGGAACAGGCATTTGGAGCTAACTTCAGTGATGTAAGAGTACATACTGATGCTAAAGCAGACCAGTTAAATCAAACAATTCAAGCTCGTGCTTTTACTACAGGACAGGATATTTTCTTTCGGGACGGAGAATATAACCCCACAAGTAGAAATGGGCAAGAATTATTAGCGCATGAATTAACTCACGTTGTGCAGCAGCAACCCCAAATGGTGCAGATGGACAAAGATGCTGTAGAACCAGAGAAAGGAGTTAATCCCCCACCAGAGAAGAAAGATATAAGTTGGATATATGATACTTTAAAACAATTAAAAAGTTGGAATGCGGTTAAAGATAAATTTATTTCTGATGAACCAACAATGCGTCAATTTGTTGAATTTCGTAAAACTTATGTAGATAGTAAAATTAACGAACTTAGACAAAAATATCCAACACTCATTGCTAAATCTGTAGGCAGTAAAGACCTAAGTTCAGATTATGATATTACTATTTCCACTCCAGGAACAGGTGAAGATGTTGAAGCAGTAGATGAATTTAACAATGCAATTAAAGCTGAATTTGGAGTACAGCCAGGGACTTTATTTGATACAAATTTATATGCTAAAGATTTTCTGAAGGTGGAGGGAAATATTAAACCAGATGTTGAGCAACAACAGCAAGAAGACTCTGATTTGGCACAACCAGAAAACCAAAATTTAGGAAAATTAACGGATTTGGATCAAGATGTTGCAGCTTTAGTTAAGCAAAGACGATTTATGAATCAGGGTGAATGGGATAAATATACTGAATCCGTTGTTTCTGGAATCGCAGATAAAAAGCAAAAACAAGCAGTTTTAAAACAATATGAAGAAGCTGATGCAATTTTTCAAATATCTGCCCATCAATTACTAGAAGAAACCAAAAAAGATGAGAAGGTACATCAAGAAAAAGGACAACTAGGCAAGGAAGAAAACGACGAATTATCGAAAATTAAGGATGGAAAAGTTCGAGAGCAAGTAGAAAAGCAGTTATTAGGTATAGAAGAATTACATTTAATTACTCACGAAAATCCCGATTTGGTACTAGAAAAAAGCAATCAACTTTATATTGATAAAATGAGACAGGTGCGTGTGCTTCAATGTCTCATTCAAAATCCTGAAGAAGAGAATGTTGATGCAATGAAGGCAGAAGTGAAAAAATTATTAGGTGAAGCTTGCTTCTTCGCTGCTGAAGCATACCATAGTGAGGGAGCAGTGAAACACGTGGTGGCAGGTTTGCAAGGAGATAATGCACAAGAAGCTCTGAAAAAACTCACACCAGAAAATATTTTACAATCTTATAATGAACAGTTGGGAGATTTCCTCAAAGATATTGTTCACTATACTCAAGAAAAAGCTCATCATGGTAAGGTCTTTTATCGTTCCTCTAAATATTTGTATCGTTTATTTGACGCTATTAAAGAGATTAAAAAACGCCCAGAATTTGCAGATATTCAGTTAACTATAGGTGATGAAAACTTATTTGCAGCAATCATAGAATCGGGATTATTAGCAATTCGCAAAGGAAATCTCAAATTTGCAAGTGAAGAAGAAACAAATTTAGCATCTGTTGACATTGTCAAACAATCTTTTGGTGTGGACACATCAGAAGGTTTGAAACAAAAAGTTTTACAAATGAGCGTAGAATTTAATCAAAAAGTACGCAATAAGTTATCATTTTTAACTGATAAAAATGCAGAAACTCAATATTTTAAAAATGTACAGCGTCGGTAACAGCCAAAATCAGAAGCAAAACTAAATTTTTATCTTGAAGTAGGTAATTTTATGGCAGAACAGGAACAACTTCAACCAAATGTTTTAACAACAGTAGATGAAGCACAAAATCTATCTGAGTTTTTGCAAACCCGACCTTTTGCACCAGTTAATAAATCTCATGCAGCTTCCAGCGAACCAGGTACACAACCAAATTTGCAGATCAAGAGCACAAATAACTTACCACCTCGCACTTCTAATTTCGGTCACAGTTTTGGAAATGTAATGGTTTTTCTTCCCACGAGGTCAGTAATTCAAGCTAAGTTAACTATCGGGCAACCGGGGGATAAATATGAACAAGAAGCTGATCGCGTAGCAGCAGATGTGTTACAACGCATAAATCAACCGCAGGCAATGTCTTCTAATCAGAGAGAGACTATCCAGCGTATGGAAGTACCGGAGGAGGAAGAACTACAAATGAAACCCCTGGTAAATTCCATCCAGCGTATGGAAGTACCGGAGGAGGAAGAACTGCAAATGAAACCTCTGGCAAATTCTATCCAGCGTGTGGAAGTACCGGAAGAGGAAGAATTGCAAATGAAGCCGTTTTTGCAGCGTCAAGAAGCCATTGATGGAGGACAAGCATCAACAGATTTGGAATCTTCCATTAATAATGCAAGAGGTGGTGGACAAGCTTTAGATGCAGGTTTGCAACAGTCGATGGGTCAAGCGATGGGAGCAGATTTTAGTGGAGTCAGGGTGCATACAGATACCCAAGCTGACCAGTTAAATAAATCAATACAAGCAAAAGCTTTTACGACGGGGCAGGATGTGTTTTTTCGGCAGGGAACGTATGACCCTGGGAGTCGAGGAGGACAGGAGTTGATTGCCCATGAATTGACCCATGTAGTGCAGCAAAATAGTGGGGCTGTGCAGCGATCGCCGCAACCGGAAGATACATTACGGCAACATCAAGAGATAATGACGGGAGCGAAAGCAGTCACCTCGATACAGCGTAAAGCATACATTGGGGACAATTGTGATTTACCTGCTAACCTCGAAAAACCAAAAAATAAAGCACTTCATGAAGACGGAGATATTAGGCGGTTTAATAATCAACAGGAATTTGAAACATTTGCGGCAGGAAGCGCAGTTGAAGGTGTTGGTCAGCTTGCGGATAAGACATGGGTGCGACTACCTAAGTCTATGCTTGTACTAGGAGAAAATCATGGTAATCCAAAGGCACCTGAAATTATCAAAGCCACGAACATCAAAAAATTCCGCTATGAGGGTTTCACCCACCACTCTGCTACTAGGCTCGAAAAAAGCGAAGAACTTCAAGGGGTTGTGCAGGAATCAAATAAAAAAAGTCTTGAGAAGAAAGGGCTAGTTGCCGGTGCTGATGAACCAACACATGAAGCAGAACACGCTCTCCCTAAGTATGCCAGAGCAGTTGCAGACGTTATAGAGTTAGTTAAAAAACAAGAAAAGGGAGAGAAAATTAGTGAAACGAGTGTCGTAGCAGGAAGCGATCTTGGAGAAGAATACTCACTTGTTAAGGCATTGCTATCATCTCTACTTCATGCCTTAATTTACTCTAAATCTTATAGTGGGAAATTTTTCTCTCATCCCCTCAAGCAATTCTATAACGAGAATCAAGCTGCTGTAGATGAAGCAATAGAAACACTTAAAGCTAGTGAACAAGGCAAAAAAGTACCTGATTTCAGTAAACTTAAAATCACAAATACACTCGATTCGCTAACCACTGCCTATGAAACGGCAGCGAAAAGTAAAGTAGGTCTAACTACACAGAAAAAAATCGATAACTTTAAAGCACAGCTGAACACCGTAAAAGAACCAAAAGTTACACTTACCAATCGCGCCAAAGAAGACGACTATCTGCGTGATGCTTCTATGCTGGAAACAATCAAGAAGGCAAAAAGTTCAGGCGATCGATTATTCGTCATTGGAGATGCCCACCGTTATAAGTTGCAACCACTCATTGAAGGGCTTGGTTTAGAGGTAATGCCAGACACAGATTTCGTAGCGCAACAAAAGGACTTAGACACATATGCGAAGAGCAATGGAAAGGATTACGGCGATGGAGACCCAAAATCGATAGGTAAATGGATTAGATCGATTCAGGAAAAATGGACACCAGATGAATTAATAAAATTAGGTTGGGGAAGGGAATCTGAAAGTGAGGAGGAGTGGGAAAAGCGCAAGGGTAACAATAACAAGGGTGGTACGGCGGTCTTGACTGATCATAATGATACTACTACTCGTTACGAAGTTGTGATAAACGGGAAGATAATAGATAAGAAAACTAAGAACTTTCAATACAAACGGGGAGATAAGTATACAATAACTGCGATTAGCAAAGCCGAACCAAAGGCAAAAATAGTGATTTATCAAAGCCAGTAAATGATGAAAACTCTATTTCTATAGGTTTAACTTCAATTGCAGTCGAATAGAGCAATAGTTTGAAGATGCGATCGCGTTTGCGGTTGGAGTAAAACTACATCTGATATGGAATGCGATCGCACAACAAAAGGTTGAGTTTGTGATTAAACCCAACCTAATTTGTGTTTGTAATATTTATTACTAAATCCCCGGAATTTCCGATAATTCACATTTTAATTCTTCTACCGCAAAACCTGTAACTTTGCGCCATTCTTCCACAGTAAACTCATAACCTTGTTCCTTTGCCATTTTGACAAAAGCCTCCTCATCTGGTGCTTGATTGAGATTTTCCCGCAAATCGGGGTTAACTTGAGCCGCTCTAAATAATCTGGTTACTTCTTGTACTGCCATAATTTATACTCCTAAATTTAAAAGACGGGTAAAGGGGAAGGGGTAAAGGGTTAAAGGGAAAAGGGAAAAGGGAATAAAAAGCTTTGAGCTATTACCCTTTGTTGAAAGTTGTGATAACTAGGTACTATCTCTTTTTCCCCATTCCCCATTTCCCTTTCCCTAAGAAATCCATCCCTTCACTTCCACATCTGTCAAGGGTCGTTCCATCTTAATATATTCACTCTTTGCAGCTTGTAATATATATTGCATCTGAACTACTTGCCCAGCCTGAGCAGCAATAAATGCAGCGTTGAGAGCAATGTTACGAATATTACCACCAGCAACATTTAATTTTGCCAGTTTCCACTCATCTAAACCTTCCGTCGGTGTGTTTTTGGGAAAAACTCGTCGCCAAATTTCTGCCCTCTGGTTCGCATCTGGGAAGGGAAACTGAACAATAAAGCGGATACGTCGCAGAAAAGCTTGGTCAATCGCATTTTTTAAGTTGGTGGTCAGAATCGATAAACCAGGGTAAGCTTCCATCCTTTGCAGTAAATAGGCAACCTCCATGTTCGCATGGCGATCGCGTGAATCTTTAACCTCAGAACGCTTACCAAATATGGCATCTGCTTCGTCAAATAACAAAATTACACCCCCAACTTCGGCAGCATCAAAAACCCTACCTAAGTTTTTCTCGGTTTCACCAATGTATTTACTGACGACTGCGCTCAAATCAATGCGGTATAAATCTAACCTCATTTCCCGTGCTAGTACTTCAGCTGCCATTGTTTTACCAGTTCCACTAGCTCCTGCAAACAAAGCACTAATACCCAAACCGCGTTTACTTTTGCCTCCAAAACCCCATTCCTCATAGACTTTGGTGCGCTGTTTGAGTTGGTCTGCTGCATCTCGCAGGACTTGTTTCTCAATTTCTGGTAATACCAAATCATCCCAGTCAGCACTAGATTCCATCCGTTGTGCTAATTCATCCAACCGAGGACGAGCTTGGGTGCGGCAAATATCCCAGAGGGATGAGGGAGATGGGGGGGATGAGGGAGATGGGGGGGATGAGGGGGATGAGGGGGATGAGGGAGATGGGGGAGATGGGGGGGATGGGGGGGAAGAAGTAATATGTTCTTCTTGTAGTTTCCCATTTCCTGTTTCCCCTTTCGTTTCCTCAAGACTTTTTGCTTTTAAGCAAACCCCGCGAATAGCGGGAGCGCTGAGGTTGAAGTGAGAAACTATGTTTTCTACTTCTTCCCCCAGAGATGGGGCAAATTCTCTCAGGGTTTGATGCCAAAGTAAGCGCTGTTCTTCGGTGGTGGGACTATCTACATCGAAGGCTATTATGGGACGGTGTTTTTGGGGACGACGTTCTTGGCTAATAATAATTACAGGAGCTTGGATGCTCTCGATAAATTGAGCTATTGCCATTTCTTGTTTGCGATCGCTATTATCCCAGTTGTCCCATTCCAACAGCAATGTGGTGTTATTCAGGGCAAATTCTCGCTCCCACAGGGATTTTACTAAGTTGAGATTACCTGTTTCATGGGGTAATAGTTCTACTCCAATGCTGTAAGGGATAAAGTTAATTTGACCACAGGTCGCAGATGCGATCGCTCTTTGACTTGCGACATCTTTTCCACACAATTGCAGGATTGGTAGTACTTCTTCTGATTGTGCTGCTAAATACCAAGTATTTGCCATCTGCATCGCTATTTGCCAATGCGATGGTACTAATTTTTCCCTTGTTTTGACGGGTGTACCAATTCCTGCCAATCTTGAATCTAGATGATGGATTCCTGTAAGATAATGCAGAATTTGTTCGTCAATTCGCAAAGGACTAGTTGTGAGAGCATTACCAGCACCAATTTCCATCAATCGCCATTTTCGCAATGGTGCATCAGGTGTTAGCGCTCCCCAATAGGCTTGTTCTAGTATTGCCAGCGCCAAGCTAAAGGTCGGATAATTACGCTGTGAATCACCTTGAATTTCGGCACAAAGGGAAGCAAAGCTAGCATCTAACTCCACTCCTGCACATAGCAGTAATATATCGCGCTCAAAAGCGGATAATCCCAAGTTTTGGCAGATTTTTTCTAAAGCTGGTAAAGAAGAGGGTGAGGATGGGGAATAACTATGTTTTTCTCCTTTTTCCTCTTCCCCTTTACCCCTTGCCCTTTCCAAAACTTGTCGCAAGCGATTGAGGTGCTGCATCAGATAACGTTGATTTTCTTGTTGCCATTCGGCACTAGGTGCTTGAGGAATCACTTTTCTAGTTCGGCAATTAAGTTGAGTAAATAAGTCTTTGCTTCTTGTGGAGCAAGTAAAATTACTTGACCTTTACGTAAAATCTCGTATTTTCCACCATGATAGCCATGACCAGCAATTAGTCCTAGTTGTACTGCTTGGTTTCCCAATTCAGTCAACATGCTAATACCAATCAAGTCACCTTCTTGTTGTAATTGTTGTTTCAACATTTCTTCAGCATCCATAAAAATAAATAATGGGGAAAAGAGGAAGGGGGAATGGGAAAAAGAGGTAAGTAGTTGTGCAAAATTAATTAATTAATTGTACATTCCGGAAACTTGAAGTCCTTGGGTGCGCGGAGCGTGTCCGTTTAGGACTTATGCTTCCTCCGTCGCAATGACAATATATATTTAATTTTGCGTAAGCACTTAGTAGGTTATCCGGCTATCACAACTAGAAAAGGGTAATGGTTCAAAGTTTGTTATTTCCCTTTTTCCTTTCCCCATCTTTCCCTTCTCTTAACTAATTTCAATTCTCGGTGTATTAAACCAACCATAGGTTGAACTAGTATCATCGCTATCGATACTCAGTAAACTTTCTGCACCATCGATTTGCAAACGTAACAAGTAAGTTGCTGGTTTGACTCCAGTCAAATTAAAAATAATGGTATCGGTATCAATATTGATGGGTTCAGCTACAAATTGATAACCAATAGGTTCGTCGATAGACCATTCATTCATAACTAACACGACTCGCTGCTTAATTCCCACCATCACATCTACTTGCAAACTTAGAATAAGCGATCGCAAGTCATCCATTGGTCGGTTTTGCTGTTCGATATTGATTTGTTTAATGGTTGGACGAAGTACAAATGGTGCCACATTGGAATCAACTGACCGATTTCCATTATTTAAATTTGCAGTCCCAATGGGAATTTGATGAATAACCTGCAAACTCTGGACACCTGCCCGCAAAAAATCAACTGGCACATCGGCTAGGATGAGAGTAATTTGATTTTCGCTGACTTCTGATGGTGAAAGTTCAAATCCACCAATTCGCACTTGGGTAATATTATTCGCCAGGTATTTACCGCGAATTTGTAAGGTACTGCTGGCTAAAATAGGTTCCAGTTTCCCAGTAGCAGAAACCACCTGCTCAACCAGCGGACGATTGGGAAATGGAACTGTACCCCCAAGATTGCGATCGCTTACAGGTAAGGCACGTTTCAAGGATTCATCACCATCAATCGTCACTACAGTAACTTTGTACACCAGCGACAACATGTAAGGAGCTTGAAAAAATACAGACCAAACCTTAGATAAGTTGTCTAAATTTATCTCCAACGGCACTACTAGTAACTGTTGGAGTTGGTTGGCAAGGTTTGAATCTTCTAAAAATCTATAGCTTGGATCTGCTAAAGCCTCCTGAATAGCTTCAACTGATACTGTTGAATAGTCATTGAAAGTGCGAATCACACTACCCAACAATCGCTGGGGGATTAGCTCTGTGTCGTTACCATAGAAACTAATCATATAATACAAGTCAACAGCCGCCTGACGTTTGATTGGCGTTCCTTTGGAGCGAAACGGTGTTGCATCTGCGTTGTTTAGAGCGGGATTGCGGGCAACATGATACAAAAAAAGATTAATACCAGTTTCTGGTGTTCCGTTACCGATATTTCTTGGTTGTAGTGTTGTGACTCTGACTCCATCGATATCTAGCTGTACCGCAGATTGCAAAATTCTTTGCAGGATGGCTGTCACTGTTGCGACAGCTAAATAATTACTCACTGTCAGTTATTTCACTTAGATAATACTTTGTTTAGGAAATAGATAAAAGTAACTTTTGTTGCTCCCTATTCATTTAAAACTTAAAACCTTTCCAATCTAGCCGAGGGAATACTTGTTGTCCATGCCTGTTTAACCCCCATTTTCTGAACTTAATCATCCTTAGAACTCTGTAAAAGACTACTGACAGTAACTTTTTTGCGTTAATCTACTATCAGTATACTGAGTTATTTGTATTACTTATGAGTTAAAGCTAAGAGATTTAGAATTCTCATTTAAAAAACCTTAACAAAAACTTGGTAAAAACCCTTTACATGTGCCAGTTTAGATATGTGATTTGCGTCACTAAGGTAAATTCAATCGAGTACTTAAGTAGTACAGTATAATTAAATGCATAATTAAGTACATATCCGTACGAATTAGTGAAAACTCTGAGTCAGGAAAACGATTGAATTGGAAGAATGCAGTAGAGATGTTAAGCAAGCAATAGCTCTAATTCAAGATTGCGATCGCTGCAATGAGGGGCGATAAGAATGGTAAAAATGAGTTTTTGTCGAAATAAAAGAAGCTCAAAACCGATCTTTTTTTTACTCAGCGTCAGCTTTATTAGGAATATTTAATGCACTCTAGAATTTGAGAGTGCCATTCACCCATATACCAAAAGAGGATAGTTACTGATGGCATTAGATTACTTTGCTCCTGGTGTCTACGTTGAAGAAGTAGACAAAGGTAGTCGCCCTATAGAAGGCGTTAGCATGAGCGTAGCTGGTTTTGTTGGTTTTAGTGAAGATGTCCGTGGGGATGCTGAACTCTTCAAACCGATGATGGTGACTAATTGGAGTCAGTATCTAGAGTATTTTGGTAAACCTGGTTCGGATGGGTTTACCGACTTTAGCGCTTATTTACCTTTTGCTGTTAAAGGCTGGTTTGATAATGGTGGTGGTCGTTGCTGGGTAGTCAGTATTGGTACTAAGTTGCCTGGTTCTTCTGCTCCAACAGTAGAAGAAACAGCGACAAAGTTGCTGACGGGAAATGGTAAACCATCATTGATGTTTAACCTCAAGCCAGCCGAGGGTGATACACCTGCTCTCATGCCCGCAGGCGATCGCTTAATCGTATCAGTTATTGACAGCGAACCAAAACCACTACCAGAAGATGCACCAGAGGGTACAGATGCACCTCTGAACACAGGGGAATTTTTCTCTGTGGTTGTCCGCAGTGGCGATCGCATTCTGGAACGGTACGATCATCTGACCATGAATCCCAAGGTAGAAACAGCAGTTGCTGAATATGCAGTCACTATACTGAAAGCTTCTGAATACGTCAGCATTGCAGATATTTCTCAAACTGGACAAGCTCTGTCTCGTCGTCCTGCTAACGGTTCCTACGAAATTGCTCCTCCTCCTTATGTTGCTCGTGAAGAACACATGGCACGGGATATGCAAGGTGCGCGTACCGATAAAACAGGTCTCCAAGGCATCTTTGAAGTTGATGAAGTCTCAATGGTTGCTTGTCCTGATTTGATGCGAGTCTATCAAGATGGTTTGATGAATATTGACCAAGTACACGGCATCATGGAAATGATGTTGAGTATGTGCGAAAATTCCTTCCCTGGTCCAGCTTTCCGCATGGCTGTACTTGATGCACCTCCTATTAAACCTGGAAAGAATGAAAACCGTGCAGTTCCAGCAGAACAGCAAAAACCCCAGGATGTCTACAATTGGTTGCGTGATTTCAACCGTCGTTCCATGTTTGGAGCACTTTACTATCCTTGGATTAAGGTTGCTAACCCTCGCAATGGTGGTAAACCAATTCTTGTTCCCCCTAGTGGTCACATGATGGGTTTATGGTGTCGTACTGATCAAACAAGAGGTATTTTCAAAGCTCCTGCAAATGATACTCCTCGTGGTGTTCTCGGTTTGGCTTATGAAACCAATATGCGCGAGCAGGAATTACTAAATCCAGTTGGAATTAACTGTATCCGTAACTTTGTAAATTACAACCGGGGTTTCAAAGTTTGGGGCGCTCGCACATTGGTTGAACCAGATAACATTCAATGGCGTTATATCAGTGTTCGTCGTTTGATTAGCTACATTGAAAAATCCATTGAAATTGGTACCCAATGGGTTGTATTTGAACCGAATGATATGGATTTGTGGGAACGGGTAAAGCGTACCGTTAGCAACTTCTTAGAGGGATTGTGGAGACAAGGTGCATTGTTTGGTGGTTCACCTGCGGAAGCTTTCTACGTCAAATGTGATGGTGAATTGAACACCCATGAAACCATGATGATGGGTCGTCTGTATGTGGAAATCGGCGTTTGTCCAGTACGTCCCGCAGAATTCGTTATCTTCCGTATTAGTCAGTGGGCACCTGGAGAATAAAAAAAAGTAAGAAATTAGGAGTAAAGAGTGATGAGTTAAAGAATAATAACTGAAGATGAAAAAATCATTAACTCTTAATTTATTTGAACTCTCAACTCCTAATTTCTACCTTTAAAAACATTTTCATTATTGATTATTTAAGGAGTTCAAATCATGCCAGAATTAAAGCCAATACCAACTAGTAGATTTTATGTAGAATTTGATGGACTGACGCAAAAATTAATCAAAAGTATCACTGATTTTAGTTTTACAGGACAGACTACAGGACACGAAAAACCTCTTGCTTCTACCAAAGATGGAAAAACACTTTGGCAAACAACTTCCGGAGGTTTTAAACAAAATCCTAACTTCACAATTGAAGTTTATCTTGCGGAAGGAGATATGGATTTTTATAATTGGATGTTAGCGACCATGCCAAAAAGCGAAGGTGGAAAAGGTGAATGGTCAAAAAACCGTAAAGCTGGTGCTTTAGTTGCTTATGATAGTGAAGATGCAGAGATTATGCGTTGGAAAATAACCAACGGTTGGATTAAATCTTACAAAATATCAGAATTTGCTTCTGATAGCAACCAGTTAGCTGTAGAAACATTTGAAGTCGTTTGTGAGCAAGTAGATAGGACGACATAATTATTGGTTATTTTCTATTGATTATTAGTCATTAGTTATGAATTGGTAATCATCAAAAATAACAAATGGCATAAACGAAAAACAAAATTTTAGTGGAGTTAAAAATGGCGAAAGGTGAACTATTAGCTTGTTCTAAGTTTTATGTTCAGTTTGACGGGTTAGAAGATTTAATAGTCAAAAAAGTTAGTGGTGTTTCTATAGAATTACAAACTGCTGGCGACCAAAATCCTTTTGGTGTTACAAAAGGAGGAAAAGCACAAATTCAAGCCACAGTTACAGGTGTTCAAAATAGTGCTGTGACTGTTGAATATGTGGGTACTGTAAATGATAATAGATTATTTAAATGGTATGAGGAATCCCACTCTCAACCGACAACAGGTGGTGGAAGTACCAATAAAGGAGCGTTAAAAACTGGCTCTATTGTTCTCTACAATCAAGGTGGTGACGAAGCTGCACGCTGGGATATGACTGGTGTAATGCCCAAAGCTTATAAAACCACAAAAATGGAAGCTGGTAGTACGGAACTATTTATTGAAATTGTCGAGTACGCTTTTCATTCTATCCGACGAACTAAATAATTTTAGTTAGTCATTGGTCAATTATTAGTAGTTAATTAAAAAATACGATATAGATGACTAATGACTAATTTTTCAAAATCCAAAATCTCAAATCCAAAATTCTGTGAGTGATAATAAATTTGAAGTTCTAACTTCTTCCAAGTTTTACTTAGAAATTCAGCTTGATGGAAGTGATAACCGTATTGATGCTTATTTTATGGAGTGTCAGGGTTTTGAACGTACATCTGATGTAATTGATTTTTGTCAAGTTACTCCGCAAAAATGGGGAAAAAATTCCTCTGCAGTTGGTCGTCTAGTTCGGACAAAAATGCCCGGAAATTCTAAAACTGGTAATTTGATTTTACGTCGAGGGATGACAACATCAATGATTTTTTGGGCTTGGTTTTCGGCAGTAGAACAGGGTCAATGGTCGCAAAAACGTAAAAATGGCGATTTAGTTCTTTACAATCAAGCCAGTGATGAACAAGCTAGATTTCGCTTTTTTGGTGCATGGCCCGTAAAATATAAGATTTCTGATGTCAAAGCAGGAAGCGCTGAGTTTGAAATTGAAGAAGTGGAATTAGCTATAGATGAGTTTAAGCGGATTAAATAACGATTTCGGAAAAATTACCAACTCATGAGCTTGCACAGAACAGAATAATCGTAATTTCTGAGGATATGAGTTGAAAATTAGGAGTTATGGGTTATAACTTAAAATGTTATTGATTTTAGATGTGGTGGATATGTGAGTTATAACTTGTAAGTTATGAGTTGTGAGTTGAAAAACAATGTAAAAGACATAATTTCAATCTCAAAATTCAGAATTCACAATTTATATATAACTCCTAACTCTTAATTATTAAAGGTAGAGACGATGCAAACAGAATTTGAATTTACCTTACCTAAAGGCTATCTTGATGAAGATGGTAATACTCATTGTAAGGGTGTGATGCGTCTGTCACGCGCTATTGATGAGATTGTACCGTTGCGTGACCCGCGAGTGAAGTCAAATCCAGCTTATGCGACGGTAATTATTTTATCACGAGTCATTACGACTCTGGGAGCCTTAGATGAAGTAACACCAGTGGTGATTGAGGGTTTATTTGCTTGTGATCTCAGCTATCTACAAAAGTTCTATCGACAAATAAATGAACTAGAATCAGATATTGCCGAGCTTGCAGTACCCGTATAATCTTAGTTTAAGTATAAAATAGTTAATGTTAACTACAGAGTTTGAGTTTACACTTCCCCGTGGGTTGATGGATGAGGAAAGAGTTATTCATCGTCATGGAGTGATGCGGCTAGCGACTGCAAAAGATGAAATAATTGTACAAAAGGATAGACGAACTCAAGACAGTCCAGCTTATGGAACTTTAGTTATGTTTTCCCAGGTGATTCTTAAATTGGGTAATTTATCTCAAATTACACCTGAACAACTAGAGAATTTGTTTAGTTTTGACTTGAGTTATCTACGGGAATTTTATGATCGCATCAATCAACAGGGAAATGCTCAAATCCCGGTTATTTGTCCAAGTTGTAACCACAAATTCCGTCAGGAGTTGATGCTATCGGGGGAATTATAAGCTATCCTTCAGACCAGCTACATGAAGAGATAGCTTGTATTGCTTATGAGTTCCATTGGTCTCTAGAAGAAATTATAAACATGGAACATCGCGATCGCCGTCGCTGGGTCGGTGAAATCGGCAAAATTCGAGAACAGATTGAGTAAGGAAAAAAGGGTAATAATTATGGGTGAAGAGAAACTGATAAATATTGATGAAATAGCCAAAAAAATTGTGCAAGACCCAATTCTAATGCAAAAGTTGAGCGATCGGGTTTTGGAACTTTTACGGGAAGATACAAGGGTATTAAAAGAACGCTGTCAAGGTTATGGAAATCGATTTTAAATATAAAAATCATAAATTAGGATAAGTATATATATCAATGGCTAAAAGTATAGATGAAGACTATGGATTAAATTTAATTTCAGCTAACCGCTTTTATGTGGGGATAGAAAGCAACATTTCAGCTTCATTTACTGAATGTCAAGGGTTAGGTGTCAAGGTAAAATACGAGACTTATCATGAAGGAGGTGTCAATGACCAGCAACGCATATTTTTGGGACAACCCGAATTTTCAGAAGTGACTTTAAAACGTGGAATGAGCGATGATCTGGTATTTTGGCAATGGGCATCTCAGTTAATGAAAACTGACGCTAGTAAGTCTATTGAACGTCGTAATGTGAATATTTTAGTGTTTAACCAAGCAGGTGAAACCATGCAATGTTGGACACTTATTGGTGCTGCTCCTGTAGGTTGGAAAGCACCTTCATTAACTGCGGATTCTTCTAATATTGCGATTGAAGAATTAAATTTGATTTATGAAGGTATTAAAGTTGTAAAAAAATCAGGTGCTGCTTCTGCAACTCCTATAAATCGTAGTGCAACCGGATATTTTGGTAGTAACTAAATAATGGCTGAATCTAATAATTTGCCTGTTACTAATAATTATAGCTCTGAGGAAAGTTTATCAACAGAACCTCTGGGTATTAAAAATCCTTTATTACCTTCTCAAACATTAGGTGAAAAGGGTATCAACCCGCAATTTTTAATTCCTTTGGGAGTTAAATCGATATCAGTTTTAGATACTAATTTAGTCTCTCCAAAATATATTGAAGATGATTTTTCTAGTAGTCTTTTTGAAGATTCTCCTTTTTTCTCGGAGTATACAAATCAAGTACAGGTAGATACTGACAGGCAAATTAATCCTTCTTTAGCTATTTCTCTACAAGTTAAAGGACAAGGTATACAAGCACAATCAGATATAAATTACTCGTCTGAAAAAATATCTAGTTCAGAAAATTTTACCCAAAGCACAGAAAACCAAGTTCAACCATCTTTGATTAATCCTGATGTAACTAATTCCCCAGAAATTCAGTTAAAGCAGGATTTGACAGAGGATTTTAAGCGATCGCATTTCAACCAAACAGCAGAAAACCAAGTTCAATCATCTTCGAGTAATCCTGATGTAGCTGATTCTCCAGAAATTCAGTTAAAGCAGGATTTGACAGAGGATTTTAAGCGATCGCATTTTACCCAAACCTCAGAAAATCAGGTTCAAGCATCTTCGATTAATACAGATGTAACGACTTCTCCAGAAATTCAGTTACAGCAGGATGTGAAAGAATCTTTTGTGCGATCGCATTTTCCCCAAACTCCAGAAAACCAGGTTCAACCATCTTCGATTAATCCTGATGTAGCTGATTCTCCAGAAATTCAGTTAAAGCAGGATTTGACAGAGGATTTTAAGCGATCGCATTTTCCCCAAACCGCAGAAAACCAGGTTCAACCATTTTCGATTAATCCTGATGTAGCTGATTCTCCAGAAATTCAGTTAAAGCAGGATTTTACAGGAAATGTTGTGCGATCGCATTTTACCCAAACCGCAGAAAACCAGGTTCAATCATCTTTGATTAATCAAGATATAACTGATTCTCCAGAAATACAGTTAAAGCAGGATGTGACAGAATCTTTTATGCGATCGCATTTTACCCAAACCGCAGAAAACCAGGTTCAACCATCTTCGATTAACCCTGATGTAACTGACTTCTCCAGAAATTCAGTTAAAGCAGGATTTGACAGAAGATTTTGAGCGATCGCATTTTACCCAAACCGCAGAAAATCAGGTTCAACCATCTTTAATTAATCCTGATGTAACGACTTCTCCAGAAATTCAGTTACAGCAATTAGATTTCAAGCAAACCGCAGAAAATCAGGTTCAACCATCTTCGATTAATCCAGATATAGTTGATTCTCCAGAAATACAGTTAAAGCAAGATTCTATAGGAAATGTTGAGCGATCGCATTTTACCCAAACCTCAGAAAACCAAGTTCAACCATCTTCGATTAACCCTGATGTAACTGATTCTCCACAAATCCAGTTAAAGCAGGATTCGATAGAACTTGGTTTGCGATCGCATTTTCCCCAAACTCCAGAAAATCAAGTTCAACCATCTTCGATTAACCCTGATGTCACGACTTCTCCAGAAATTCAGTTAAAGCAGGATTTTACAGAGGATTTTAAGCGATCGCATTTTCCCCAAACTCCAGAAAACCAGGTTCAACCATCTTTAATTAATCCTGATGTAACTGATTCTCCACAAATCCAGTTAAAGCAGGATTCGATAGAACTTGGTTTGCGATCGCATTTTACCCAAACCTCAGAAAATCAGGTTCAACCATCTTCGATTAATCCAGATGTCACGACTTCTCCAGAAATACAGTTAAAGCAGGATTCGGCAGAATCTTTTGTGCGATCGCATTTTACCCAAACCTCAGAAAACCAAGTTCAACCATCTTCGATTAACCCTGATGTAACTGATTCTCCAGAAATACAGTTAAAGCAGCATTTGACAGAGGATTTTAAGCGATCGCATTTCAACCAAACCGCAGAAAATCAGGTTCAACCATCTTCGATTAATCCTGATGTCACGACTTCTCCACAAATCCAGTTAAAGCAGGATTCGATAGAACTTGGTTTGCGATCGCATTTTACCCAAACCTCAGAAAATCAGGTTCAACCATCTTCGATTAATCCTGATGTCACGACTTCTCCAGAAATACAGTTAAAGCAGGATTCGGCAGAATCTTTTGTGCGATCGCATTTTACCCAAACCTCAGAAAACCAAGTTCAACCATCTTCGATTAATCCTGATGTCACGACTTCTCCAGAAATACAGTTAAAGCAGGATTCGGCAGAATCTTTTGTGCGATCGCATTTTACCCAAACCTCAGAAAACCAAGTTCAACCATCTTCGATTAACCCTGATGTCACGACTTCTCCAGAAATACAGTTAAAGCAGCATTTGACAGAGGATTTTAAGCGATCCCATTTTCCACAAACTCCAGAAAATCAAGTTCAACCATCTTCGATTAATCGTGATATAGCTGATTCTCCAGAAATACGTTTAAAGCAGGATTTTACAGAATCTTTTGTGCGATCGCATTTTCCACAAACTCCAGAAAATCAAGTTCAACCATCTTCGATTAATCGTGATATAGCTGATTCTCCAGAAATACGTTTAAAGCAGGATTTTACAGAATCTTTTGTGCGATCGCATTTTCCACAAACTCCAGAAAATCAGGTTCAACCATCTTCGATTAATCCTGATGTAACTACTTCCCCACAAATACAGTTAAAGCAGGAATCGCATTTTACTCAAACCTCAGAAAATCAAGTTCAACCATCTTCGATTAATCCTGATGTAACGACTTCTCCAGAAATTCAGTTAAAGCAAGATTCTACAGAAGCTTTAGTGCGATCGCATTTTCCCAAAACTCCAGAAAATCAAGTTCAACCATCTTCGATTAATCCAGATATAGTTGATTCTCCACAAATTCAGTTAAAGCAGGATTTGACAGAGGATTTTAAGCGATCGCATTTTACCAAAACCGCAGAAAACCAGGTTCAAGCATCTTCGATTAATCCAGATACAACTGCTTCTCCACAAATACAGTTAAAGCAGGATTCGATAGAATATTTTGTGCGATCGCATTTCAACCAAACAGCAGAAAACCAGGTTCAACCATCTTCGATTAATCCAGATGTAACTGCTTCTCCAGAAATTCAGTTAAAGCAGGATTTGACAGAGGATTTTAAGCGATCGCATTTTACCCAAACCTCAGAAAATCAAGTTCAAGCATCTTCGATTAATCCAGATATAGTTGATTCTCCAGAAATTCAGTTAAAGCAATTAGATTTAAACCAAACTCCAGAAAACCAGGTTCAACCATTTTCGATTAACCTTGATGTCACGACTTCTCCAGAAATTCAGTTAAAGCAGGATTCGATGGAATCTTTTGTGCGATCGCATTTTACCCAAACTCCAGAAAATCAAGTTCAACCATCTTCGATTAATGCAGATGTAACGACTTCTCCACAAATACAGTTAAAGCAGGATTCTACAGGAAACGTTGAGCGATCGCATTTCAACCAAACCTCAGAAAATCAGGTTCAACTATCTTCGATTAATCCTGATATAACTACTTCTCCAGAAACACAGTTAGAGAAATTAGATTTTAAGCAAACTCCCGAAAATCAAATTCAAGCATCTTCAAGTAATACAGATATAAATTCCGAAAAATCAAATATTCATGAAGATAAAATTCGCGAGCTACCACAAGTATTGCAAAAACTAAGTATTTTAAACCCTATTGCACAAAGAAAATCAATCAATGAATCTCAACAAAAGTTAGATTTTACGACAACAAATATCGATAGTAAAGCATCAAATATAAACAATCAAATTTCTACACTACAGACTAAATTAGACGCTACTCCAATATTTTCAACTGTTTCTAACAAAAACTCTAGTTCTAATTCGTCTCAATGGTCTGATTTTAATAGTCTAATTAGAGGACAGACTACTCCTTCAAAAAGACGCAATAATCACATATCAGAAAGTAAAACAACAGCCATACAAGCAAAAATGTCCGAAAATATAGAACCAATTAGAGTATCACGCAAAGAAGATTTTCAAGCTGAATATGAAAATAATTCATCTAATAATGTCAGCAAAAATGAATTAGAAATAGTAGCACAAGCTATTTATCAGCAGTTGAAACAAAGAATTAGGATTGAATTTGAGCGTCATGGACAGGGTTCTTTAGGACGCTTACCTTGGTAAAATTTATTGTAATTATATCGTCATAATTAAGAGGAAAATACTATGTCACTCACAAAAGCTAAACTGGTTTCTTCTGATGGTGGTGGAACTATTGAATTTATGTTTAACCCGACTCAGCTAAAATTTTCTCAGAGCATTAGCTTAAATAAGAATGAAGGAGCAAGAACAGGTAGAGGATTGCCAAAAGTTAATTTTGCTCATCCACAACCTTGTACTCTGAGTATCGGAGATATTATTTTAGATACTTATGAACAAGGAAGCAATAAAAGTGTTCTTCCTTATATCAAACAGTTTGAGAAAGCAGTTAATTTCTTGGAACAGGGTTGTGAAAAAGATAAACGTCCCCCTACTTACGTGTTTACATGGGGTAATTATCAATATATTCGTTGTTTTATTACTAACCTTGCTTATACATTAACAATGTTTTTGCCAGATGGAACTCCCGTCAGAGCAAAGCTGGATTTAACTTTAGAAGAAATTGACGAATCAACCTCCCAACCAGGTATGGGTACCCCTAGCAATCCCGATCGCATAGGTGGTGGTCGTTAGTAATATTAACAACAATATCCCAAATTGAGTTTGGTGGAACATTAAGCATTAAAATGTGCTTTAGCTTACTTCGAGGTCGTTTATGACTGCTACTTATACTGCTACACCGATACTGAAAATTGACGGGAAGGATGCAAGTGCTAATTTGTTGGATGATATTTTGAAAATTTCCGTAGAAGAAAGCTTGCATTTACCAGGGATGTTCACCTTGATGATTCGCAATGATTATTATGGATCTCGCAGTGGTGAAAACCCTTGGATGCATGATAATACTTTTGCTATTGGTAAATCCATCGAAATTGGTTTTGTTTCTAGTACAACCGAAGATAGTAGTTTTAGTAGTCCAGAAAAAAGTACCCTAATTAAAGGTGAAATTACTGCGATTGAAGCACAATTTAATCCAGAATCCCAAGCACCAATAATTGTGAGAGGTTATGATATTAGTCACCGTTTGCATAGAGGACGTTACAACCGCTCTTTTCAAAATATGACTGATACAGATATTGTGAAGAAAGTGATTGGTGAAGTAGGAATTGCTGCTGGTAAAATTGATAGTACTGGTGGTCCCTATGGATTTGGTGATCCGGTTGGTTATACCTTTCAAGAAAATCAAACCAACATGGAATTTCTTCGGCAAAAAGCTGCACGTAATGGTTTTGAATTATTTGTACAAGATGGTAAATTACATTTTCGTAAGCCTGTAGCGGGTGATTCTTTGAGTTTAAAATGGTTAAAAGATATAACTCACTTTCATGTACGTGTTAGTAGTGCAGAGCAAGTAAGTGCCGTTGAAGTGAGGGGTTGGGACTATCAAAAGAAAGAAGCAATAGTATCTAATAAAACTAGTCAAAATTCTCAAGTATTAACATCTACTCAGCAGGGAAAAGGGGAAGCTAGTATTAGTGAATTTAATAAAAATCCGACCATGATTGTAGTGGATCAACCGATATTTTCTCAAAAAGAATCAGATGCGATCGCACAATCAATTTTTAATGAATTATCGGGGGAATTTGTCCAAGCTGATGCAAAAGCTGAAGGGAACCCTGAAATTCGACCTGGGAAAGTGGTTAAGCTGCAAGATATGGGTAAATATAGTGGGAAATATTATGTAACTGAAACTCGGCATTTATTTGAAGCTAGGGTTTACACCACCGAATTTAATGTGCGTGGATTGCGAGAAGATAGTTTAGCTAACTTTATCAGTCCCCAAGCTCGACTACAACCAGGACAAACTTTGATGATTGGAATAGTTAGTAATAATAAAGACCCAAAAAAATGGGGTAGAGTAAAGGTGAAGTTTCCCACTTTAACAGATAAACATGAAAGTGATTGGGCAAGAGTTGTTTCTGTTGGTGCGGGGAAAAATCGTGGTTTTGATTGTTTACCAGAGGTAAATGATGAGGTATTAGTGGGATTTGAACATGGGGATATTCATCGTCCTTTTGTGATTGGTGGGGTTTGGAATGGTAAGGATGCTCCTCCGGCAAATGTAGATGATTCTGTGGTGGAAGGTAAAGTCAGGTTGCGAACTCTGAAAACTCGTACTGGTCACACACTTCAATTCGTGGAAGAAGATAAAGGTGACAGTAAAAAAGGAGTTTATTTAAATACAGTTTATGGTCATAAGTTGCATCTGAATGATAGCGATAAATTAATTGATATTAAGACTAAGGATAATTATCAAGTTACCTTAGATGACCAAAATAAAAAGATATTAATTAAGACAAATAAAGGATATATCTGTGAATTAAATGACCAATCACAAAAAATAACTCTCAAAGCATCCAGTCAAGAAATAGTACTGAAAGCTTCCGGTCAAATTGAGATTAATGCCCAGCAAAATATTACTCTCAAAGTTGGTGGAAATAAAATAGAAATTTCCACGACAAATATTAAATTAACTGCGGGTAGTAGTTCTATTGATTTATCACCTGCGGGAGCAACTCTTAAGTCTTCTGCGATGACTCAAGTGGAAGGTTCAATGACTACTATAAAAGGTAATGGTACTGTAACTGTCTCTGCTCCAATGGTTTCAATTGGTTAAGTAAAAATGGCTTTTAGCTTTTAGCTTTTAGCTTTTGGTTTTTAGCTTTTGGAATAAATAGTGTATCAAGTATAAATCTTATTTTTACCCACTTCCTCTTAACTGTAGCTTGATCAAAGCGGAGCAATACAGTATTGGAAACAGTATTGGAACATCTCTACAAAAATTCAAAATCTAAAAATATGCCTCAACAAGTTGTTATGGGTGCAGCATTACAATGTGTCCCTTTCGGTGTTGCTCCAAGTTCTCTAATAGTTATTCCCAAAGGTCCCCCCGTGCTAGCTAGCGGAATGTTGGCAGCAACTATTATGGATTTTGCCCCGATCGCAAATATTCCTCCATTTGGAATGTGTAATTCTCTCGCAAACCCGATGGTAGCAGCTGCTACTGCTGCCGCATTTGGTGTATTGACTCCAATGCCTTGCCTTCCCGTAATTCTTGGACCTTGGAAACCAGGAGCAATCAAGACTCAGATTAATAAAATGCCTGCTTTACCAAGTACGGCAATATGTAATTGTGCTTGGGGTGGTGTGATAAAAATTGCTTTCCCTGGACAAATTAAAGTCAGTGTGAATTAGGGGAGTGCGGGAAGTGTTGAAAAGATGCTTCCTCCCAATCTTTCCCATCTCCCCCATCTCCCCCATCTCCCCCATCTCCCTCATCTTCCCTTTCCCTCATCTCCCTCATCTTCCCCATCCCCCCCATCTTCCCTTTCCTTCATCTCCCCTTTCCCTCTATTCCAAAGGTACAAGTCCAGTTAATTTCAATAAACGTTGACCTTCCTTAGTTTTCAAAACTTGGGCAAATTTTTCACCAATTGGGGAACGATTGTTATCTATGGGGTAGACAACAGCGATCGCATATGCTCCTGGATAGCGTCCAGTTCTAAATAGTTCGCTGTTGGGGTGATAACTACCTTTGCGATCGCATAAGTCGGTATTGGGTTCTATACTTTGATTGTTGCTGAGAATAACTGGTTGAATTGGGGGTTTTCCTTCAATTTGTAGTGCTAAGGGGTACACAGAACATTGACCAATGATTTTGGAGAGGGAACCAAAACCGATTCCCCCTGCTTGCTGGGATTCAAAATCCCGTAGTACTGTTCGCATCATTTCAAATTCTTGAAGCTCTTGAGATGTTTTTAGGGAATTTTCTTTCGATTTTATTGTTTTTAATAATTGTTGTATAAATACCTGTTGTACTTCTTTATCTACTGGTGCGTAAATATTCACAGCGAGATTTGGTCCTCCTAATTCTTGCCAATTAGAGATATTTCCTGCATACAACTGTTGCAATTTATCTACAGTAATTTGTCCGTTGAGCTTTTCTGGTAGTCCTTTTTCCCGTTGCGAATAACTAAAGGCAACAAAAACCCCTATCCCATCATAGGCTATAGGTTGAGCTTGCAAATCTGCTGGTAAAGGTTGAATTAGAGGTACGATCGCAAATGCTGATTTTCCCGATTGCACTTGTGCGATCGCTTCTTCTGTTGATGTTGTGGGTTCATAACTCAATTGCAATTTGGGTTGAGCAATTGTGATACGCTGTTCTAATGTTTGCCCTTTTTGAATTAAGTCTGATTGTTGAATTATATAATCCCAAATACCATTTTTAGAGGCTGTATAAGTAAATTTGCCAATGGGTATTGCTCCCACTTCTTTAATTAAGTTCAATTGAGGTGTATTACTGGTAGCATTACTCAATTGTGGTTTAGCAAAGAATAGCCAAGCAAGTCCCCCAATGACTCCTAAACCTAAAGTAGTCAATAAAAATATCAGTAAACGGGGAAATTTAGTCCGAGTTTCGGTTTCCGCTTCTGCTGAAAACTCTACAGGTACTTCAAAAGCAGCTTTGGGTAATTTCAATAATTCCTGTCTGGCAACTTCCGCACTGATAAATTCACCTTTTATTAATCGTCTGATAAATTTTTTCAGGTGCGGATTAATATCACCCCAATGAGTTTCATTTTCTGGATCGATTGCATAGCCTGCATCGGAAATAACTTTACCCAATAGTAAATAAAAGGCAATATAACCCAAAGAAATTAAATCTTGAGGTTTATCTGCATTCTCCAACTTATCTTTAAAGTTATTTTTAACTGATGTCTCTGATATCGGTATAAATATGCGTTCCCAAATAGCTAAGTCGCACAAATAGATAAAAAAGTCCAAATCCTCCACAATCAAACTACCTATGATTGTATCTTCATCAATCACTTTTAAAGACTGTTCGTAACCATTATGATTACTTTTGACCATTAACAGACTATCAAGATTAATATTCCCATGAACCACACCATTTTGAATTTGAGCCGAAGGAAAGCGGAATTTTTGTCCGTGCAGAAATTCGAGAGTTTGCAATGTCTGATTTAAAACCAAATGTACCTGACTCGAAGACATTCCTTGATTTTTTTTATTTTCCTTATTTCCCCTTACCCTTATTTCCCCTTCCCCCTTTCCCTTTTCCCTTTCTTCCCTTCCCCGACAATTTGCCAAATAATTATTCAAAGTTGGACATGCATAACGCTCATCCATCACTAAATAACAACGTCCTTGTGACTCATCAATAATTGCTTCTATAGGTTGTAAAAAACGAAAATCTTGTACCCTTCCATCTGCCAAACAAATACCCGCTACAGACTTAAATAATTGTAATTGCTTATATATTTCTTCCGCATTGAAATAACGTCCAGGCAGCAAATATTCTTTGATAATTACAGGTTGATTTATCCCCAACTGAGTCGCAGCATAAATTCGTCCCATTCCCAATCTTCCCAACCAGCGTTCAATCCGGTAAACTCCCCGCAATCCGGCAATCTTTTGCTGTTTTGGTTCCGGTAAATTGGGAATGAGTACAGGTTCCGCAAGTAACGCAGGAAAACCACAACTAGTACATGCTTGGGTTTTGTCTCCTGCCTGGGTAATTGGCAAAGCGCGATCGCACTGTAAAGGATCATTGCACACACAAGCATATCGCTGATAAGGTGAATCAAAAAACTGTACCCCTGCTTCTCGTGGTAAATCGGGAGGTGGAGTAATAGTTTTTGCTGTTTCTTCTACTGTTTCTGCTTCATCTGCAAATAATTCTCCCTTTAAATCCTCTAAAATTGGCTGCATCCAACTCCAGCGCATCAAGGCATTATATTTAGTATGCTTGAGTACCCGTGAATACTTATTTAAATAGTTCTTAACAAAGGGTTTGAGAATTATTTGAGGGACTTTTTGGAATTTCATCTAATTTCTTTGTATTTTCAGGTGACTTGAAAGTAAGTAGCGATACTGCCAGCAGTTAGCTATTAGCTATTAGCTAGAAGACCAATAGATAAACGTGAATAGTTTTTTTAGAAGTTCATTTTTTAGTCGCTCTTAGTAGAACAAGAAAAAACCACATCAGGATTTTCGGGAAATAGTATTACCTCTTCCTCCCTTCCCTTTTTCCCTTTTCCCCTGCTCTCTTATTTGCGATGCTTGCTCTTTCATCACCATCTTAAGATTTGCCTTTGCGACTACTTGCTGGGGATTGAGTTTTAAAGCTTCCTGCAAAGCTGCGATCGCTTGGGGATAGTATTTTAATTTTGAGAGGATAATTCCCCTACCCGTGAACGCATCAGCACTTTTGGGGTTAATTTTGATGGCACTGTTGTAAGATTTTAATGCATCTTTGTGACGGGAAAGGGAGGTGAGTACCAAACCGCGATTGTACCAAGCTTCAAAGGAGTTGCGGTTGATTGCAATCGCGTGATCGGCTGCTGTTAATGCTGACTGATATTGTTTTAAATGCCACAATACTACACTAGTATTTGCCCAGCCTTCAGGATTTTTGGGGTCGAGAATCAAGGCTTTTTTATAAGATTGTAGTGCTGTTTTATACTGTTTCTGCGTGGCTAAAATAGTACCTTGGTTAAAATAAGCTTGGGCATAATTGGGTTTAAGCTCAATTGCCTTCTGGATTGATGCTAATGCTTCTGGATACTGCTGTAACTGCCACAGAGCCACGCTACGATTGCTCCAAGCTTCGGCATAATCGGGTTTTATCCCCACCGCTCGATTCGCTGCTGCAATGGCTTTTTCATACTGTTGCTGACCGGATAAAGCATGTGCCATTTCACTCCAAGCTTGAGCAGCACCGATTTCTCCCCATTGACCATCACCCTTAATTGCTTCATCGCAGGCAGCTTGTGCTGGTTCATACATCTTATTGCGGTTGAGCATCGTACAACGTCGCACATGTCCTAAAGAATACTTAGGGTTGATGGCAACGGCACGGTCAAAAGAAGTGAGAGCTTCGGTAAAGCGGGAAAGTTGTTCTAAAATTAGACCTTGGGCAGTCCAAGCGATCGCATCATTAGGGTCAACCGCTAATAATCGATCGTAGTCAGCGATCGCTTTTGATAATTGGTCTTGTTGACGGTATGCGATCGCTCGATTGGAATAGGCAAAAGTTTGACTTTTCTCTCCCCAATCCCCATTCCCAGCTAAAGCATCATTACAATTAGTGATAGCTCGTTCGGGTTGCCCGATTTTATTCATCAATTCGCAGCGATATGCTAAAGCGAGGGAATCCTTGGGTTCTAATAACAGCGTTCGGTCATAGGCGATCGCAGCTTGGTCAAGTTGACCGAGATTAGTTAAAATGACACCACGATGCAACCATGCTAATTTCGGTGATTGCTTTCCCCAGTTTCCATCCACCTTTAAAGCTTGGTTACAATTATCCAAACCTTCCTCATTTCTTCCTAACTCGGAAAAAGCCATACACTGATAAGTTAGAGCCAAAGAAGTTTTTTTATCGAATTTCAATGCTCGTTCCGCACTTGCGATCGCTTCTGGATATTTTTTCATTTTCAGTAAGACACCGCTATGATCTGCCCAAAGTATTGGGTTTTTCGGTCGTAAAGTAATCGCTTGTTCACAAGCTGTTAATGCTTCTTCGTATTTTTTACTTTGCATCTGCAAGTTACACAAATTCGACCAGTAATTTGGGTCTTTTAAATCATCTTCTAAACCCTTTTGAGAAATTAAATAGGGTGTGGGTGTATTTGATATAAACGCTGAAGCTTGTGTCTGATTTACTGCCAAATGAATTAGGAAAATACCCACTATGTTAGCTAATTTTTGCAGATTATGTATAGATGTGATTTTCATAATTATTCATATAGTATGGGTTTGGTGATGTTACTCCTGAAAAGCTAGTTCCATGAAAAGTTTGTTACTTTCTCTAATCATTTCTTCACTGCTAGTATCAACCGCAGAAGCTGCTAAAACCAGCCACATCCTCAAATTAAAAGAAACTAGGCAATGTGCTGAATGTGACTTAGAAAATGCCAACCTCAAACAAGCTTTCCTCCAAAAAGCCAATTTGCGAACTGCCAACCTCAAAGATGCAAATCTCAACGGAGCAGACCTGAGAGGGGCATTTCTGCAAAAAGCAGACTTAAGAGGAGCAGACCTACGAAATGCCAAATTAGAGGATGCGAACTTACAAGGAGCCAAGTTAGACGGAGCAATGCTCAAAAATACTGTTATAAGCGATCGCACGGTAATTGAGCGAAAATGGTTAGATATTTTTCGGTTAGTAAACGCACAAGTATCCAATCTTGACCTCAGTGGTATTGACCTTACAGGGGCAAATCTCAATGGTTTAGACCTCCGAAATCATAACCTCGAAGGCGCAAACTTGCAAAATGCAACTTTAGAGCAAGCTTTACTGAGTGGTGCTAATTTTAACCGTGCCAATCTTCAAGAAACCAGTTTTTTTATTAGCGACTTGAGAAATACCAGCTTTCGGGAAGCGAACCTCAAAAAAGGTAGTTTACAAGCAACAGACCTGAGAGGGGCAAATCTCAGCCAAACAAACCTCACCCGTACCAACCTCAGTAGTGCTTATTTAGAAGGTTCAAACCTCCGCAACTCAAATTTAAACAATGCCAATTTAGCAAGTTCCATCCTCAGGGAAGCAGATCTGAGTCAATCACAACTTCGCAATGCTAACCTGTTTTCGGCTGACCTCCGAAAAGCTGACTTAAGTGGAGTCAATCTGCGTGGTGCTAACCTGCGGGGTGCTGACTTAACTCAAACCGAACTCGAAAATGGAACATTGCGAGGAACTAAACTAGATGGAGCAATTCTCCGGGAAATGAAATTAAGCGGTGCAAACCTAAGTCGTCTTAACTTGAGTAACGTTGATTTTAGTGGAGTTAATCTCAGCAATGCCAATTTACGGGGAACAAATTTAAGTGGTGCAAATCTGAGTCAAGCAATTCTTGATGGTGCTAACTTGGAGGGAGCAAATTTAAGTGGTGCAAATCTCAATAAAGCAATTCTTGAGAGTGCCAATTTATTAGAAGCAAATCTCAGCAAAGCAAATCTCAGCGAAGCTAATTTAAACAAAGCAAATATTACCCGTGCTAACCTCAGCGAAGCCAATTTACAAAGAACTATTTTGAGCGAAATTAAATTGGAATTTGCCAACTTTTGCGGTGCGATCATGCCAAATGCTTCCAAAGGTAAATGTTAAAAAATAAGTCCACCAATTGATAAAATGAGTTGTTGACCGAATGTCCGCCAAAACGATGAATTGCTACGGTTAATCCTAAAAAGAATTGGAACGCCGTTACAAGTAGATATTAGAGACAAAGATGAAGATACAGTTGGATATCTATCCAGGGCTAGCGCGTCTCAAAGACTATTGACAAGCGGACTTGCCTGATCAGCAATCAAGTTGAAAACAAAGTGGCACTATCCAAGCTAGGGTAAGATTTAATCCATCTAGGTGCCATTGGTTAGAGTAATGCCAACTTTCCTTTGAGAACAAGAAAAGAAAAACTAAAGCATCTTTTGCACCCAGCATAGATAGCAAAGACATTACCACTAAGTTTCAGGAATACTTCACACAAATAAAAGACCCTAGAGTGGAAAGGACAAGATATCATTTACTTACAGATATCATCACCATAGCTATTTTGGCAGCAATAGCAGGAGCAGAAGGTTGGAAAGATATTGAGGAGTATGGACTCAATAAACAGGAGTGGTTGAAAACGTTTTTGGAACTACCATTCGGAATACCTAGCCCCGATACTTTTAGGAGGGTGTTTGAGAGAATTAACCCAAAAGAATTTGAGCAATGTTTTCGGCAGTGGGTGCAATCACTAGTTGAGAAGTTGGGAGTAGAAGTAGTAGCCATAGATGGCAAAACTCATAGAGGCTCATATGATAGAGCAACTCAGCTAAAAGCCTTACATAGGGCTTGCTGATTAAAGCTATAACCTTTGCCAAATAAGGGTTTTAATCATTTTTGAGGCAAACAAGTGCAAGGTTATGGGATTTAGAGGCTCAAAAACCATGCACTTTGGCGGAAAATCACGGGGCGAATTTTGGATCTGACCTCCAAAAGCAAGATTATTCAAGCTGTGTGGCATCTAGATTCGCTAAGAGAAGAAGAAACAGGAATAATCTGTCAAGACAATTATCGAGCTAGAGGAAGAAAAAAAACAGAGATTTTACAACCGATGCTCGAAGCAGATATTAAGAGTTTAGTAGATAGTCAAGCACAAGCAGACCCCAAATTCCAATCAAATTTTTATTATGCGCGGATTAGTGCTAGAGCCGTGAGAGAAAAATTAATCTCATTCAAAGGATACGAAGATAGTCTATTGCCTAGTCGCCAAACGATAGGAGATATATTGAATAGAATGGGATATATTTTAAAAAAACACTAAAAACGAAGCCTCTTAAAAAAATTCCGGAAACGGATCAAATATTTGAAAACGTAGAATCTGCGTATCAAGCTTCAGATCGAAATCCTAAGTCCTTAAGGATATCAGTGGACTCAAAAGCAAAGGTCAAGATTGGAAATTTGTCGAGAGATGGTTACTCACGTACAATAGAACCCAAGAAAGCAGATGACCATGACAGTGAATGGTCTGCGGTATTAGTTCCATTGGGAATTTTGGATGTATTAGGTAATAGATTATCAATTTATTTTGGTAAGTCAGCAGAAACAACTGACTTTATTGTTGACTGTTTAGAAGCTTGGTGGCAAGAAAATAAGCCATCCTATACTGGATTAGAGGAATTAGCAATTGATATTGATAATGGCTCTGCTACCAGAAGTAATCGAACCCAGTTTATAAAACGAATCGTGCAATTTTCTCAAAAAACTCAATTAAAAATCAGATTAATTTATTATCCACCTTATCACAGTAAATACAACCCGATAGAGAGATGTTGGGCAGCACTAGAAAACTACTGGAACGGAGCTATTTTAGACTCAATTGATGCTGCTATTAAGTGGGCTAGTAACATGACTTGGAATAGCATTTCACCTCAAGTTCAATTATTTGAAGGAAATTATGAAAAAGGGGTTTCTGTTTCTTCTCAAGAGTTAGAAGGTTTTAAACCATTCTGGCTACAATCTGAAAAATTACCCAAATGGGATGTCACCGTATTTCCTTGCTAACTGGTATTTTATTTTCACGCAAGTCCCAAACGACGGGAGTTTAAAATATCAGGGTAAATTTCGTTGAGGTGGGTAGCTTTCCAGAGTAAGGAAGCTGTCTGTAGTTGTACTTCTGATTTTTGTTTGAATAAATATCCAGCTTCACACAAAGCGCCTATTAAGGCATTAATTAAATCGTTGTATTCGTCTTCACCTAATGGTTGCGATCGCCCTAACGACCAAGCTTGAGAAGAGCGTAAAAATTTTCCCAGCTTACTTCTAGATGTTAATTTAACTTTCGCCTTCCCATTAGTGCCACTTGCAGTAGTTGCCCAAGTTGCTTCGTGTAAAAGTTCATTTTCATCAAATCCCCAGGGTTCCTTGATGGCCAGGACTTACGCAACTGGCACAGCGCGAACGACTTACGTTGAGCAAGCTTCACATTCTTATAGTAGATATGTACTAAATTAATGTGGCATCCTCAAAGGAAATTACGAAAATTCGTAACAGTAATCTGTTGTGTTAAGTATTCATCAAATCATGAGAAAATTAGCTAGGGATGCATAAAATAAATCCTGTAGCTTTATGAGATTTACTAAACTTAACTATTGCCAGTATTTGTTAAGTAGTCAGATTAATTATACTCTGACAAATTTGGCAGACCATTTAGAGCAGATCAGTCATGATAAAATCAATCGTTATTTAAAGAACGAAAAATTAACGCCTCGGATTCTTTGGGATAACGTGAAAGATTTAATAGAAATCAATGATAATGCTTACTTAGTTTTTGATGACACAGTAATTGATAAACGATACGCTACTGAAATAGAGCCAAGTAGACGGCAATATAGTGGCAACGAGCATGGTGTAATTCAAGGGATTGGGTTAGTAAATTGTGTATATGTAAATCATGAAATTGGAAAGTTTTGGGTAGTTGACTATCGTATTTATGATCCAGATAGAGATGGAAAAACAAAGATAGACCATGTGATGGAAATGCTGCAAAACCTTGTTTATCATAAGGCTTTACCATTTAAAGCTGTCTTAATGGATACTTGGTATGCGACAAATAAATTGATGTTATATATTGATGGATTAGGGAAATATTATTATTGTCCTCTGAAACGTAATCGACTTGTTGATGATACGGCAGGCGAAGAAGAGTATCAAAGAATTGAATTGTTATCTTGGGATGAAGAGGAGTTAAAATCAGGTAAAATAGTTAAAATAAAAAAGTTCCCTCAAGCTAAAAAAGTGAAACTGTTCCGGGTAACTGTCTCCACTGACAAAACGGATTTTATCGCTACAAATGATTTATCTCAAGACTCTACGGACGTTGTACAAAAAGTGTGTAAAGTTCGATGGAAGGTTGAGGAGTTTCACCGAGAGTTAAAACAATTGACTGGTCTTGAATCATGTCAATGTCGTAAGGGTCGTATTCAAAGAAATCATATTGCCTGCGCTATTTTAGTCTGGCTTCGACTTAAAGATTTAGCTTATAAAAGTGGTCAAACAATTTATAAAATTAAGCATGGATTGTTGTCAAATTATTTAGTTCAACAACTAAAACGTCCCAATATTCCAATGTTTTCCTTTTAGGTTGTTTGGCGCTCGGTGCGGCGTAGCCGCACCATTGCTTGTGACAGTTGCGTAAGTCCTGATGGCTTGCAAAACCTCGCGTTTAAGTTGGTCGCGGCGATCGCAAAGTTTCATCGAGTCCATCAAAGTCTAATTCTGCACAAACTTTTTGTTCCTGCTGAAATACCCTTTTCCTGATTTCTTCAATTGCTGCGAATTCATTTTTTAAAGTAGCAATTTTTACAATTATTTGACTCATGAAAATTTTCCCTTTATGAATTCATCTACTAAACATCTGAGTAATTACTCCTTGATACCTATCTGTGACTATGTTGCGACGGATTTTTAGCGTTTGAGTTAACAGACCGTTTTCGATCGTGAAAGGTTCTGGAATTATCTCAAACACAATAATCTCATCATCACGACGATAACCTTTGCGATCGCGTACTTCACGGTTGAGTTCTTCCCTGATTAAGTCGCGAATCATTTGGTTGTTTAAACCTATCTCACCATTTACAATTGGCTGATTTTTGCTTAAAAGCCAAGATTCTAATATTTCTAAGTCAGGAACAATCAAAGCACCAAGAGATTTTTGGTCTTGACCGACAAGCATAATTTGGTCGATATAATCACTTCGCAAACAAGCGTCTTCAATGGGTTGAGGTTCGATATTTTCCCCGTTTGTCAGTACTATTGTATCTTTAGCTCTACCCGTCAGCACAATTTGATTGTCTGGTGTCAACCAACCAATATCCCCAGTATCAAACCAACCTTCACTATCGATAGCTTTGCTTGTAGCTTCTGGATTTAAATAATATCCTTGCATAATTTGCGGTCCCTTTGCCATTACCAAACCGCGTTTCCCTTGGGGTAAGGGTTGATGTGTTTCTAAATCGACAATTTTCAATTCCGTACTCGCAAGGGGTAAACCGGAAGCTCCACGCAGGTTTTTATAATAACGACGTGCGCTAAGTACGGGAGAAGTTTCTGTTAATCCGTAACCAACTAAAATCTGAATTCCCACAATTTCAAAAAAATCTTCTAAATGCTGTGCGAGAGAACCACCTCCACAAATTAATTGTTTGACTTTTCCCCCCGTTGCTAGCTGAATTTTTTTGTAAACTATCATTTCGCCGAGAAAATGTAGGGGTGCTAGTAAAATAGTTGTTATCCAAGCATTAATTATTTGGGAAGTTGTCGGATTTAAGTTTTGCAAATCGATTTTTTTCCAAGTCCTCACTGCTTTAATATATTTTTTGCTCACTGCCAGAAAACTTTTAATTAATTTTTGCATTCTGGGTGTTTTATCGCGAAATGATTTTTGAATACCTTCATAAATCGATTCCCAAAGACGGGGAACACCAATAACATATTGGGGAGTATAATCTTGTAAATCTTGTTTTAAATAACGACGATTAGAATAAATCTGCGTGACTCCTTGTCCAAGGGTATAGTATTCGCCAACACGCCCAAAACTATGCCAGGTAGGTAATATACTTAAAGTCTTATCACCTACTGATGGTTGAATAATCGCCGTTAAAGTACTAATTTGATGTAGGAAGTTTCCGTGGGTTAGCATTACACCTTTCGGCTTTCCAGTAGTTCCAGATGTATAAATTAAAGTAGCTAGTTTTTGATATGCTAGTTCTGTTGGTTGTAAAGAACTTTGACTTGCTATTTGCATTAATTGCTCGAAGTTTATGATTATTAAAGAAGAATTAATCGAATTATTTTCTGGTTGTTCATCTGATAATAATACTACCCATTGAATTTGAGATTGATATACCTCCGGTGCTATTTTATTGAGAGTTTTGAGATTTTCTATCACTAATCCAAGACTGCCACTATGTTCTAATATATATAGTAATTCTTCCCTCTCTGCGGCAGAAGAACGCACAGCATTTGCAGCACCAGCCATCATAATACCCTGGTCGGCTATCATCCAGCGGGCGCTATTATCAGCAAATAATGCGACTATTGGAGTTACAGATTCTGTCGAATGTTGCTTGATTCCTAATGCTTGTAGACCTGCGGCAAATTGCTGTATTTGATAATATAATTGGCTATAAGTTAAAGTTACTTTTGGCTTTGCGTGGGGGTCAATCAGAGCGACTATATCTGGAAATATTTTTGAGGTAATTTGCCACATTTCTGGTAGCGATCGCACATCTGAATAATCTACTAAACCAGTCATCTGGTAAAGTTCATTTTTATGGAAAGAATAAGTTGTCATCTTGTTTTCTGGGGTTTTCATATATTTAATACAGCTAATATATATCTCTGTCTGGTACTTTGAAAATACCTGATTACTATTAATTCAGTTTTCTGGGGAGAATTTGACAAGTTGTAGAAAATTTCCAAAATAGGAAATTTTTCCTCGTCAAAAATTATCGTAACTTATAGATAAAATATTATATACAGCAATTTGCGTTGTCATGGGTTACAGGTAGAGACGTAAGATTGCTAAGTCTCTACAACTTTTTTGGTATACATACATGTACCTACAAGCTTTAAGATTGACTTGAGCAATAGTCAATCTACAATTTATGAACAGCATCAAATATTTTGAATATCCCAGCAAAGAAAAACTGCTAGGATTACCCCCACAGCTAGGTCGCTGGTTATTTATTCCCCTGGGATTAATTGTCTTATTATGCTTGGGAACCGTTTATTCATGGAGTATCTTTAGCGGTCCATTTGAAGCAGAACTGCAAACAAAACCAGGGACAATTCTATTACCCTTCATGGTTTTGGGGATAACATTCACCCTCGTGATGCCAATTTCTGGACTATACATATATAGATTTAGTCCCCGCATTATGACTACAGTTGGTGGGATAATCGTGGGGATTGGCTATTTATTGGCAAGTGTTGCTCCTAATCTCCCTTTACTAATATTGAGTTACGGTGTTATCGCAGGTATTGGTGTTGGGATTACTTATGGTGTACCTCTTGCTGTTGCCGCACGTTGGTTCCCTGACCGTAAGGGTTTAGCGGTGGGACTAACGGTAGTCGGTTTTGGTCTTTCACCTTTGGTAACAGCACCCATAGCTTTAAATTTAATCAAAGGAAATCCCCAGATTGGTATCCCAGCTTTTGGTATTCGCAGTACTTTTGTCATTTTAGCTATTGCCTTCACTATAATTATTTCGATAATTGCTACTGTACTGAAAATGCCTCCTCCATGCTGGAAACCTTCCGGTTATGCATCTTCTGAAAAATTGGCTGTTAATAATACAGACAAAAACCAGTCTAATATCTTACCCATGTTCCAAACCCAAACTTTCTATGGTCTATGGATTTGCTATATCGTTGGTACCTTTGTTGGGTTAACAGCGATCGCAACCACAGCACAGGTAGGAAAAGAGATTGTGGGACTGCAACCAGAACAATTAGTATGGGTCGTTCCCTTGTTTGCAGTATTTAATGGTGCTGGTCGTCCGTTATTTGGTTGGTTGAACGACCGTCTCAAACCCAAATTAACTGTTATTACGATTAATCTGCTGATATTAATCGCGTCGATTGTGATGTTAAATACACATAATGGACAGATGTCCAATTTTCTCGTTGCATTTTGCTTATTCTGGTTATGTCTTGGAGCTTGGTTAGCAGTCGCACCTGCTGCAACTCTCAGTTTTTTTGGCTTAGAGAATTACCCCAGCAACTACGGTTTAATATTTACCTCATTTGGTATCGGTGGATTATCTGGGATTTTTACCGCAGGAGGTATCCGAGGTGCGACTGGTAGTTTCTTACCTTTTTTCTGGGTAACGGCAACTTTAGCCTGTATAGCAATCATTCTCGCAACTTTCTTCCTCAACCCTCCCAGAAAAACAGCGATCGCTGATTTTTTGTTTAATCGTTTGATTAGTCCGATTAGTCCAGGACTACTTTCCTTGGTTGAGTTTTTTCTCATGGTTGGCAGTCGGAAATAGGGTGGGTATTGGGTTTGGTGGGTGGTGATAAATGCTAACCCACCCTACATTTATTGGCTAATTGATTTTTTGGTGTTCCCTAATTGCCAACCTCAAACCCAATCTTAAAACTGCGATCGCAAATTCTCTACTCTGCTCCCTCTCAATCTCCCCTTCTTCCTTGACTTCTAATGCTGTTTTCTTCCCACCACTTACTAATTCTTTTACGAGGTCATTGCTAACTTTGGTTAGTTGACGTAGTGCAGAAACGCTTCAGTTTTGAACATTTTGACGCAGCAAGTTTTGCACTTTTGGTGCTAGCTTATTAAACCAAAGATATATTTCCATCGCGCTTTTCGCTATATAGCGAGATGCACCAAAATCGTCACTTTTTAACCATTCTTCAAAGACCTTTTTCCCTTTGGGACAAAAAGCCAAACAGTCATAGTATAAATCCTGGAGAATCCGACCAGTTTCTATTAAAGAGTCAAAGGTCGAACGGACAAAACTGAAGAATTCAACCAGTGTATTCTTGGCTTTGCCTTGCAGTTCTGGTTTATGAAATTGACCATAATCAAAGTTGTAGTCTAACGAAATCACGCTATATCCATTCATCTGCATTCACACTCCTTGCATTGCGGATGGACTAATTTCCTCTGCTCTGAGGATGATATTTATGAGCTATTAACGTCATTTTCGTTCAAATTTAGTTAGTCAATACTTACCTTTTGACGTAAAGATGTTTATTACTATAGTGATAAAACAAACTATCACTATAGTGATAGAGGTTTGGGAATTACATAGCTGAAGCTGTTGCGTGTTAATGCTTGTAGCTCAATAGCTTCTGTAGAAATATTGAATCAACTTGATTTTGTTTTTTTGTACAATAATTGTTGAGAAATAGATAATTCTGTATAACTTTTGAAAACTAACTTGAGTTTAATAAATTGAAAATATTCTCTAAATTAAAAAAATTGAGGTCACACCGATGTTTCAGTTAGCTACAAAACAGCAAGCATCAGAGATATTAAATATGAGTTTTTCCACGCTGAAAAAATATCGTTTAGATGGGACATGGATCGAAGGAACCCATTGGGTAAAATTGAATAGCCGTTGTATTCGCTATAATTTAGAACTTATTCAAGATTGGTTGCATAATCGTCAAGATCCGATTGCTCACTATCGGGCGATCGATTTATATCATGCTGGTTTGGCTAGTAATCAAAAACGTAGTCAGCAAAAAGCTTAGTCAGCCTAAATCACTCTTCATACAGTTCTATTGTTGCGTCGATAAAATTCTGCCAAATTTGATTCGGTTGCCAAATCTGTTCGAGATAGCGACGGGCTGAAATTTCTGTATAACCTTTACGAAGTCGATGGTAGAGGTACATCATTGCCGAGACACGCATATTTTTGGCACAATGTACCCAGATTTTTCGCTCTGGATTTTCATCAAGTTTTGTAGCAAGTTCATCAAAATCGCTGAGGGTAGGATTTTCCCAGTCGATGGGAATACCGATATATTCCATTCCCAAGTTTTCAACAATCGCACTTTCTTCGGGATTCCAGTTACTTGATGCGGGGGTCGCTAGGTTGATAATCAAGTTGTAACCAGCTGATGCGATATCTGCGAACTGTTCTGTGGTTGGCTGTCCGGAGGTGGTAATAGTAGAGGAAACAGGGAGAAATGCTTCGATTTGTGCTAGGGAAGACATGAGATGTTTGATTTCGGATTATTCTTAGATTTTAATTTTTCCTGCCGATATTGTTTGAGTTGCTGCTGTAAATCGGGTGGAAATTTTTCCATCCCATAGCGCAATCCTTCACTGGAAAAATAGGTGCTATTGGTTTTGATAAAGTCAATGACTAAATTCCTATCGCTCAACCCTAATTCCCGTAAAGCCCATCCCGTACCAGTTTGCGCGAACCTTTCTGAAGATTGAACTACTACTCCACAGCTATGGAGCAACATTTGGGTAAAACCAGGAAAATTACTTTCTCCATGTTTGGCAATATTGACGAAACTGACAACTGATGCTCGTTTACGCCATAAATTTTCAGCTTCACACCATTGCATTATCGCTTCTGCACAGGATTTTCCTTGTTGTTTGATGAGGGGATTGAGAACTTTGACACAAAGCCAATCGCAGGTATTCCACTCTTTAATATAAGCTTCGTCGAATAAGGTGGCGAATTTTGGTAAATCCGATTCCCAATTAATCAAGCGGTGTTTGAGCAAAAATTCTTGCAGTAAGAGAATTCCCGCTAATTTATCCTCTCCCCAAGATTCTTGAATTAAAGCAATAGCAGTATCAAATTGTTGAGTTACTGGTTGGCTGGAAAAATTAGCGGTTTTTGCCCAGGAATGTAATATTGCTCTGACTTGGGGTAATTTCAATCCGCGAAAAGGTAGTGAGTGCTTGAGATAAGCTTCCCACCATTCCTTAGTTTTACTATCATCCGCTTGGGCTAATTGTTCTTGGAGTTGGGTAATCAGGTATTGTGCCATTACCGTTTTATTCTAGAGATATCCTAAGCAGTGCGATTGCCTTTGTTTTAATTATCTTTGAATTCTTCCAAATTAATGAAAGACTCCCGTGTTTGGGAATTAATGCTAGACGCAACTTCAAATTTAACCACTCCTATCCCTTGGACAATTTTACCCTTATACTTTTGCACTTCCGAGGGCGATCGCTATTTATCAAAAGATGATTGATCAAAGGCTGAAATGACCTATTTTCGTTGAATCACAAGAGAATGAATTTGTACAGTGCATAAGTCCTAATTTCTGTTGTCGCCCTGGGGCTATCATATTGAACAGTATCACTAATCGATACATAGCGCTCTGGATATGTTGACTCAAGATTTTACCCAAGTAACCCTCATCCTGCGATCGCTGATCGATCTACCAGACGACGAAGCGATCAAAGCAATAAAATTATTTCAAACTTCCTTATTGAAACGGGGTGAGTTTTTTGTGCGTGCAGGTGAGATGCCCAAAACCATCGGGATTATTATGTCAGGTATTCTGCGCTTATATTATGTTGATTCGGACGGCAACGAATACTCGAAATCATTCTGCACTGAAAATAGTTTTGTCGCAGCCTATAGTGCTTTGCTATTGCAGCAGCCCTCACGACTGTTTATTCAGGCATTGGAAGATACAAAATTAATGATTGCCGATTATGCTGTCTTTCGAGAACTGTCAACAATGCATCCCTGTTGGCAAAGCCTGAATTCCAAAATTGCAGAATTTTTATTCATTAAGAAAGAAAAGCGGGAAAGTTCCTTGCTCTTAGATGATGCGACAACGCGCTATTTAAATTTTCAAGCAGAATATCCTGGCTTGGAAACACGTATCAAACAACATCATATTGCGTCCTATCTCGGTATTACCCCTGTCACCTTAAGCCGCATTCGTGCCCAACTGCGATACTCCACAGGAGTCGCTACGCGATCGCGTTAAATCAGAACAATGCCAGTTAACCTATGTTAATGAAATCCTTTGGATAACTGTTTAGGATAAGTTCAATATTTAAAATGACTGGAGTGATTTGTGAAGACAAACCATAACACGGTTTTGATTACAGGTGGGACATCTGGCATCGGTCTGGCTTTGGCGCAACGGTTTCTTCGAGAAAGAAATAGCGTGATTGTGACAGGCACCAATGCTGAAAAAGCGCAAGCTGTGAGACATCAACTGCCAGCCTTGATCGTTGAACTTGCTGATATGCGCGATCGCCAAGCCCTCGAAAAACTTGTCTACAATTACCCTGATGTGAACATTCTGATCAATAATGCAGGCGTTCAGTATAACTATGATTTCGCCGATCCAGCGATCGCAGTTGAGAAAATCACCGACGAACTCGACATTAACTTACTCAGTCCGCTATATCTAACCAAACTTTTTCTGCCACAGCTTTTGAGTCATTCTACAGCAGCGATTATTAACGTTTCGTCCGGGTTAGGAATTGTCCCCAAGCAAAGTGCCCCCATCTATTGCGCCAGTAAGGCTGCACTACACAGTTTTAGTAAAACCTTACGCTGGCAATTAGAAACAACGTCTGTACGAGTCTTTGAGATTATTCCGCCGATTGTAGATACGGCAATGACTCAAGGAAGAGGACGGGGAAAGATTACACCAGAAGCATTAGTTGAAGAATTTTGGCGGGATTTTAGCCGCGATTTCCCTGAGATACGCATTGGTAAAACCAAATTACTGTTTGTCCTTCAGAGACTGATGCCAACACTCGCAGAACGTATCATGCGTCCTGGGCTTTAAAAATATTGAAAAAATTGATCTACCTCAGATGCCTATAAGTGGTGGTTGAAAATAAATGTTACATTTTGAGAATCCCAAACCATTGCAAATACTGCACTCTGTCCATAATCGTCATGTGTAATTAATTTTCAACTTGAATACGCACTTATTGTCTTTATTTTAATTATCTTTGAATTCTTCCAAATTAATGAAAGACTCCCGTGTTTGGGAATTAATGCTAGAAGCAACTTCAAATTCAACCACTCCTATCCCTTGGACAATTTTACCCTTATACTTTTGCATTTCCAAGGGCGATCGCAATGATTGCTTGTTCCAGGATGGGAAAATATGTACGACTGTACCATCCTCCAGCACAATTTGAGATTTGATATAAACACCTTGAAAATCTGGATTTCCTGTAACTGTGGGTTTACTAGATTGTGATGTGTAATATCCTACAAGTTTGACTTTCTTGCCATTCAAACTAGCCAAATCTTCACGATTCCTGACTATTTTCAGTTCCCCCATAGAAGCTTCCCTATGATTAACTTCGGGGATTTCGCTGTTGCTTGGTTCGCTGGCTATCAAGATAGAGCAGGATAAAATAGTCGGTAAACATAGGTACAAAGTAATCCAGTTAAATTTACTATTCATTATAGATATTGAAAGGAAACAATACTGATAACTTATTTTAGCTAGATGTAACATTTTTTCTGATTTCCTCGATGACAGCAACTGCACCTGCAATTCCCTCTTCAGCTTGAATTCTCGCTCCTAGATTCGCTGCACGCTGACGCATAGCTTTATCTGTCATAACCTGTTGAATTGCTTCTGCAAGTTTCTCTGCCGTGAGTTGCTTGCGGGGAATCGGTTTTGCTCCTACTCCTAATTTCGCTACATGCTCTCCCCAAAAACCCTGGTCGCCAAAGAAAGGAATAATAATCGAAGGAACACCAGCTTGTAAACCTGCGGCTGTTGTCCCCGCACCACCATGATGCACCACAGCAGCAACACGCGGGAATAGCCATGAATGGGGTACTGAATCCACGAGGAAAACCGTACTCGGTAAATTTTGCTTACGCAAACCACCCCAACCAGCAAACATAATAGCCCGTTGTTTACTCAGAGCAAGGGCTGACAAAATGAGATCGACTGTTTCTTCTGGATTCCGGTTGCCCATACTCCCAAATCCAATGTACAGGGGAGTCGAACCACTTTCTAGAAACTCCATCAGGGCTGAAGGTGGGTTCCAACCTGGTGCTGAATCCAAAAACCAATAGCCAGTCACATGGGTATTATGCCAATCCGATGGCTTGGGAATCACTGATGGGCTGAAACCATAGAGAATTGGATATTGATGCAGGCGATCGCAGTTGTATAGCCCCCAAAATGGAGCCGCTTTTAAGCCAAGCACTTTCTCCCGCATCAAGCGATCGGCTGACCGAAATCCCTGCCACATTAGCTGTCTAGTTAAATGATGGGACAAACGATTAAAGAATCCTCCGAGCTTGGATATGAACTGGGGAAAAAGCACACTGGGAAATGCTTTTGTTGGTGTAAAGGGAAAAACATAGGCTTGAACCAATGGCAAATCTAATTTTTCAGCCAGGGCAAGGGCGATGTTCTGTCCTCCAACACCTACAAGCAATAAATCCATTCCCTGGCAGGCAACTAAACCATCGTTCGCCCAATGAATTGCTGCATCCTGGGCTAGTTTTGCGGTGTGGGATGTAATTGCAAGAAAATTCCCTTTCTCCAAAAGCTCTCGCATTTCTTTGGTTTCAATAATTTCTTGCACGTTACCCTGAACTGGATAGAACTCCAAATCATGGGAACTAACCAACTCTTCAAAGTTTTCATGAGTCGCCAATCGCACGGTATAACCAGCTTGTTTTAAACCCCTTCCCAAAGCAATATAAGGCTGAACATCCCCTCGACTTCCCAAAGCTATAATCGCAATACGCATAGGTGACGCTCCTTTTGGACGTTAAAGTTGATCGATCATGTAATTGGTTTTGCACTCTCAGAGGAAGTACAATGACATAAATGTCAGTTTGATGTTAACGTCATTTTGATAAAAACGTCAATTGAAGTTATGATAAATTCGTAGCTATTTTCATCCCAGAATATGGAGCCATCGCGTCGAGCATCAATTGGTTTAGAAAAACGGGAACGGACGAGAAGGAGTCTAATTGAGGCAGCCTATCGGGTATTTGCTCGAAAAGAAGCAGATGCCGTTACTATTGACGACATCATTGCTGAAGCAGCAGTGGCGAGGGGTACTTTTTATAACTACTTCCAAACAAGGGAGGATGTGCTTAAAGCTGTTGCTGCATCCCTGAGTGATGATATGAATCAGAAGATTTGGGCGCAGTACGCTATGATTGATGACCCTGCCGAAAGGATGGCGATCGCAATTCGCCAATTTTTGCATCAGGCAATTCGGGATTCCACTTGGGGATGGGTGATTGTCCGAATTGGATTGGTGGCAGCTCCATTGAGTGAAACAATTGAAAGGGGAGTGATGACGGATTTGCAGGCTGGTATCAGGTTGAAGCGTTTTCAAGTTGATAACGAAAAGGCTGCAATTGATTTAATTTTGGGAACGGGACTGATGGCTATGCGTAGTATTCTCGAAGGGCATACACAGCCTGATTATCCTGAACATATTACCAAACTCATTTTAAAGACATTGGGGATTGGGGATGCTGATGCGATCGCTTTCAAACCTTTAGAATCACTACCAAGTTAAAGGTTTTTGTAACTGTGCGATTCGCATAGCGGACTTTCGTATTTTCCAGTTCAAATACCTTCCAAATAAAGCGTCCAAGCATTAGCTAGCAAATTAAGTTAATCATACAAAACTCATCAAGAGCGATCGCTAGTTTGACTCAGTAACGAAACGAGAGTTGTAAACAACATAGTCATGCCTGCTGTTATAAATAGGGCTTGCTGAAAAAGTCCTATTTAAGCCAGACCAAGAATCAGTTAACAATGCTTGTAAGTGAAAATATAATTCATTATATGAACTAATTTGAGTAAATATAATATTTTCTAATCATCCAAATCTAAAAACAGGGTAAATGCAGTATTTCCTAAAATAGATACAAAAAAAAGTCATAATAATCCGCCGCAGTAATGCTCCAAGATTCATGACTAGAAAAGTTATAGCAATGGCTGTTTCTGAAGTATTAGAAAGTTTGGTCATCAATCGAGCAAGGCTATATCTTCTTTTTGCTTCTCCAAACTTTCCTTCAATACAATTACGGTCTCTCTCATCTAATTGTGCCTGCTTTTTAGTTTCTGTACTAATATTTTTTGCTGGTCGTCCTAATGCTGGACCACTAATTCTGATTCCTCTTTCTTTACACCATTTTCTATTCTCTTTGTTTCGATAAATCTGATCTACATGCACTGATTCTGGATAGTATCCTGTTGCAGCTTTAAATGCTTCTACTTGTTCTTTTAAATCATCTGATTCATTAAAATTATCCCAACTAATCCGGTCTAAAAATACATATTCTTCGTAACAACTAGCTGATAACTTGGCTCCAAATTCCACTGATGAACCAGCTTTTCCCCTTACAATTGGACGGACATGAGGTTGTGTTAAACTCACGATTCTATCGTCAACACGAGAAAGACTATTTTCATACATGAATAACTGTTGTCGGTATACTTGATTTACCACTAATAGTATTTTATATTTTTGGCTACTTAACCACTCTAGCTTGGCTCCGACTGCTATTAATCTATCTATATGTGCTAAGTTTCTTTTCAGGTATCCTAGTTGTTTCTTTACTGCTTTTCTTCTTTGTTTTTTCGATGGTCGTCGTTTTTTCGCTACGTCGAGATATTCTTTTCTAGCTGTATTTCTGTAAGTTCTGGGTTTTTTATTTTCGTTGTCATCTAATTCTTCATACAGAATATCTATTATTTCTTCTGTTTGCTCTCTCGCCTCGTTCAATAATCCTAAATCTGTCGGATATTTAATATCTGCTGGTATACAGGTTGCATCTAATTTTAATTTACCTTGATTTCTTTCTTCATTTATTTCTTCTTCTCCTCCAAGAATAATAACTTTTTTTCATTTGCTTCTTCACTTTCTTCTTCTCGACTATTTTTGACCATACTCTGATTCATTCTATTAACTAATTCTATATCTATTCTTTGTCTAAAATGAACTAGCATCGACGCTTCAAATGGTGCTTCATTGCTATACTTATTCAACCCTATAAAATACTGTAAATAAGGATTCTCTCTTATTTGTTCTACTGTCTCTCTATCGCTTAATCCCAATCTCTCCTTGATTATTAAAGCTCTGATAGCTGTCCGAAATGACTTTGCCGGTGCCCCCATTTCAATCCTAAATTGTTGGGCATATTCATCTTCAAATTCTGACCAAGGAATGAAATTAGCCATAATTACCCACCTATTATCCTCTGCCAATTGCCCCTCAAATGGCAATTCAAACTTTTCTATTGGGGTGGGTGGGTTCTCAATTTTTCTATACATTTTTTATGCCGATGTTAGGGTTTTGAGCCATTTTACCTGATTTTCTTGCACTTTTTACCTACCTATCGACCTCAATCACTGTTTCTACAAGGGTTTCATCTTTAATCAGCAAGCCCTATTTAATGAACAGCAAAACTTTCAAGGAGATAAAGGATACCAAGGTGGTAAAAATATTACGACTCCTTATAAGAAAAAAAAGAAACAAGAATTAAGTGAAGAACAAAAAACAGAAAATAAGATTTTATCGAGTCAACGTATATTCGTAGAACATTTAATAAGAATAGTTAAAATATTTCAAATAGCATCTCAAAGATTTAGGCTGAATTCTGACGTTTATAATGAAATAATTTTAACTGTATGTGGACTGGTTCGATTGCGAATAGGAACTTTAATTTTATGAACTATTAACATGAATAAAAAATAGTGTTTGCATAAATGACGCTATTCTACATTTATGCTCTAAACTATCGGTAACTATCTCAAATGCTTATTACTACGTTGTCCAAGAGTCTACAAGATTTGGTCTCAAAGCCTTGTAAATATTAGCTTGCGAGTTTTAGGACGTGTCTAGTGATGATATGCCAGATATCGTGGGTTTGGCTTAGTCGTAGTTCGACATAGTGGGCATCGGATTCTGCCGCCATTCCCGCATGGAGATTAGGGTCAAAACCCGCTTTCTTCATTGTGGCTGCATAGATGTAGCCCAAGGAATCTTGGGGATAGGTGAGTAATGCTTCAAGATCATGGGCTGGGGGAATATAGCGATCGCATATCAACGCTGCACAAGCCGGATATTGTTTTAAGTGTTGGGCAGTCAAATCGTAGGCAGGGGTTTGTAATAACCCGTCCACCATGTCGCCTACCGTTTGCAGACTATTGTCCCCTAACAGCATAGAAACGAATGACTTAAAAATGATTGCTCGTGCAAAAAATGACTTGAAACCATTGCCTACTGGATATTGTATCTGCCGTTGAACGTCAAGGTTAGCAGATGGATTGGGATTAAATTGCATCATAAATATCTCCAAAAAATCATTAATTGAACGCAATCAGGTACAGCTAGATGTTGCTACCAAAGCAAGTCATTTAGCACTCTATACAAAAGTAAGTGGAAAGGAGCAAAGACTAACGTCAACCAGGGAGAAACCTGATAGCGTATAAAACGAAACCCGAAGTAGCTGCATCGAAGAAGATAATGAGGGCGTATACTTGCTTTCGGGCGAGTGGAAAATACCCTGCCCAAAAACGACGGGGCTTCCTCTGACTTCTTCAAACTCAGGGGATTCTGGCTCATAGCAAGACTCTCTGGGACAAATTAGATTAATATATGAGTGTTACTCATGTATTAATAATATGAGCATATCTCATGTTTTGTCAAACTAAATGTGAGGATTATTCATCTTTTTTTTGAGGTAGAGATTAAATAATGGCAGAAAGTTCATCAAGCTCTTCTGGAATGCGACGCAAGCCCCGTCAAGCCCGCAGTCAGGAACGGGTGAGCAGAATTTTAGATGTGGCAGAAGAACTGTTTATTGTTGAGGGTTACACCGCGACAACGACCAATGCGATCGCCACACGCGCTCAGGTGCCGATTGGCTCGCTCTACCAATTTTTCCCAGACAAGACAGCCATTCTCAAAGCCATTGCCTTGCGCTATGGGGAACTACTACATCAAAAGTTTGCAGCCTTCGATGGGGTTGAGTTGGCAAAACTTCCCCTATCTACTTACGTGGAAAAATTGATTGATACAGCCGATCAATTTTTTACTGATAATCCAGGCTACCACGCTATTTTCATGGAGGTTCAGGGGACGATACCTGAATTGGAGGAAATCGAAGAGGCTGCCGATGCTCAACTAATTCAGGATTTGCTAACATCCTTATCTCAACGCGATTCAACCTTAGAACCTGCGGATTATGAAGCGATCGCCTTTGTGTTGGTAAAAGCTATCGGCATGTTACTGTGGCTATCTCTTAGTCAAGAAATACGGTTACGGCAGCGTCTGGTGGCAGAAACGAAACGGTTCACCTTAAACTATCTGCAAAGCTATTTTCCATCAGACTCATTACCAGCAACTACTGAAGCGGACTGACGGGAAAAGTCAGTAACTTCTACGGGCTTTCGCTCTCCCCAAACCCTAAAACTCCGGCAAGAAAAGCTCCCGACTTTGCCCCGCATAATGGCGGTAAATAATCTCTGGTGAATTACCCACCATCGTTGCCACATCCTTCACATCCACCCCATTCTTCAAAGCCATCGTAATAAATGTATGGCGAGTTTGGTAAAGTTTTCTGTACTCAACACCATCAAGGCTTTGCACTACAACCTTCCAAGCTCGTCCACTGAGGTTATGCATATCTATCCACTTACCTTCAGGTGATGGAAACACCTTTGCTTCACCCGACACATCAACGGGTTGGATGGATTTTAACAATCCAGCCAAACGATTATTAATTGGAAAAATTCGCTTTTTCTGCGTCTTCAAACCTGGTTTACAAGTCAATCCCGACTGGGAAACCACCACCGCTTGCTCAAACCGAATCATCGTAAAGTCCAACACAATATGCTTCCACTGCAAAGCCACAGCTTCTGATGGTCGGCAACCTGTGATGAAAAGAAATTCAATCAACGGTGCGTAGTATTTGTAATAACGATTTTCCTTGAATGCTCGGATGATGCGATCGCGTTCCTCCAAAGAAAAAGGATTAATATCCGTCTCCTCAGCATCACCCTTCGGCAATTTAATATCACTTGCCATATCCTCAAACGGATTATCATCAATCAATTGAGATTTCACAGCCCAATTACAACCCACATTCCGCACTTCAGAATGTAGCATTTTATGCTACATTAGAACTCTCTGGCACGAGTAAATAAAAATACTCGTAAAATTCAAGTAAGACAGTATTAAGAATCAGCCAAAGGTTATTAAGTATACAGAAAATTGCGTAGGCGATTAATACTGGTTTCAAGCTTTTGAGAAAAGTTAATATATATTGTTTTATCGTGCCAAATTACTTAGATAGCAAAAGTGAGACAATTAAAAAAACTCAAAAATATTTGAGAGGTAAAAATGTCACCAACTTCAATTGCAGAAATTAAAAATATAGATCATCTCGGAATAGTAGCTGGGCTAATTGATGAAATAGGAATAGTTGAAACAATTAATTCCAAATTAGGAGTAGACTCCCGTGAGAAGATTACAGCAGGAGTATTGGTAAAAGCTGTTTTAATCAATGGATTAGGATTTGTATCAAGACCTTTATATTTATTCAAGCAGTTTTTTGATGATAAAGCAATTGAATTATTATTGGGAGAAGGTGTAGAAAGTAATTATCTCAACGACGATAAAATTGGAAGAGTCATGGATGATTTATATAAATATGGATTGAATAATTTATTTATAGAAATTGTCCTATCAGTAATTAAGAAATTTAAAATAGATACAAAATACTCACATTTAGATGCAACTTCATTTCATTTACACGGGAAGTATAAAAGAGAAATGAATCAAGAAAAAGAAGAAGAAATCACTAAAGAAAGACCAATATTCATAACCAAAGGATATTCTCGTGACCATAGACCAGATTTAAAGCAATGTGTTTTAGATTTAATCACGAGTAGTGATGGAGATATACCATTATTAATGAGAGCAGGAGATGGGAACGAAGCAGATAAAGCAGTATTTGGAAAAATCTTAATAGAATTTAAAAAACAAATAGTTTTTGACAGTATTATGGTCTGTGACAGCGCATTATATAGCCAAGAGAATCTCAAATTAATTGAGAATTTAAAATGGATAAGTCGAGTGCCGATGACGATTAAGAAAGCACAAGAATTAGTTCAGTCTGTAAATACAGAGGAGATGGAAGAGATAGAGGAGATAGAAACAGAAGAAAAGGAGATAGAAACGGAAGAAAAGAAGAAAAAGACATATCAAGATTTAGACGGATACAAGTGGAAAGAAGAAATAGTTAATTATGGTGGTATTAAACAAATTTGGCTAATAGTAGAAAGTCAAAAAAGAAAAGATAGCGATTTAGAAAAGCTAGATAAAAAGCTAATAAAAGAAAAAGATAAAGTTGAAAAGTTGCTTAAAGAGTTAAAAAGAGAAGATTTTGAAACTCCAGAGCAAGCACGATATAAACTAAAAGGTATCAATAAAAAGCTAAAATTCCATGAAATTAAAGAAGCTAATTTTATTGAAAGTAAATCAAAAAATAATAAAACTATTTATAAAATGGAAGGAGTAAGTTATGAAAAACCCGAAGAAATAGAAATACAAAGAAAGGAAGCTGGAAGGTTTATTTTAGCAACTAACCTAGTTAATGACGACGATAAATTAAAACCAGAAGAAATTATTACGACTTATAAAAATCAACAGTCTTGTGAACGAGGATTTAGATTTCTAAAAGACCCCTTGTTTTTTGCAGATAGTTTTTTTCTTGAAAACCCTGAAAGAATCGAAACTATGCTATTTTTAATGTCTTTATGTTTGCTAGTCTATAACCTTGGTCAAAGGGAACTGAGAAATAGCTTAAAAAGAATCAAAATCGGAATCAAGAATCAATTAGGAAAACTAACTTTATCTCCGACATTAAGATGGGTATTTCAATGTTTTCAAGGAATTCATTTTTTAATGTTAGATGGTCTTAATCAAATTGTTAATTTAACATCAGAACGTCATTTTATTTTGAGTTGTCTGCCCTCATCTTGTCAAAAATATTATTTACTTTCTTAACTTAAACAAGATTTGGACAGGAAATAAAAATTTATTGAAATTTCAAGGAGCAGTAATTGCTCCTCAAATTTTTAGTGCTTACGTAATCTATTTTATGGGTCAATCTTTTTGTCTTTGATTATTTATTTTTAAAAGTATATTCATTCAGCATTCTATTTCTTCATCATCCTGACTTTTTACTTTTTCCTTACTTGTAATCTTTTTGTACTTCAAATTGAAGTGCGGAATGTGGGTTACAACAAGCCGAAAATTGAGTCAGGATTTTTTTGGAAGATAACGGACTTTTATTGGCAATCAACCAATCTCGAATTGCGATCGCTTTATCTAAAGTTTTCACCGGGAGGTGAACATTAATACAGCGATAAATTTTATGGTAATCCTTCGCCAAAGTGCTGGGCGATAAACTCGATCGCTTATATTCGGTGTAACTGTCCCACAAATCCGCTAGAGAAGCATAACTCTCAACAACTGGTGTAACTGATGGTGTAAACACAACCTGCTGGGATTGGGGTTTGTACCTTTCCAACGTCACATCGAAATTGTTGCAGAGAATATCCAACTCGATTTGCCGAGACTTCATTTCAGCCAGCTTGCGGTTGGCTTTGGTATCGGTAAACCCGGTTGAGAGATAATGCCGTTTACCCCCAAAACTGAAAACTAATTGCAGGCGATCGTTCGAGGTTTTGATTTGAACAGTACCCTTAGAGGCTTTGCGTTGCGAACTCACAGGTGACTCCTGAAATTCAAGCCAAGACACAGGGAAACTGCTAGCAAGTTACCCCCGCACCTTGAAAACATTGAAATCAGCGCGCTCTGATTTACCCCAACTTTACCCCAATAAATAGTCCAAACATGTCCAAAAATGTCCAACGTCGTCATATTCTTGCACCAAATTTGTACCCCTAGAATGGCTGGAATGGGGTTTTGGTTGAAATTAAAACCCCTGAAAGCTATGTGTTTCAGGGGTTTCGATGGTTATGCCAGGAACGAGACTTGAACTCGTGACACGAGGATTTTCAGTCCGGCTTCAATACACTTATATCAGTAGTTTCACGGTTTACAAAAACCTTTACCCCCAATTTACCCCCAAACTCAATTTGACCAAAATTAGTCCTCCTTTACTCCTCTGGTCTCGGCACTTAAACGCTGAAAATGTCACTAAAAGATTTAAAATGGACTTGAATCCATATGGCTTTGAAGTCATAATATTACAGTATGGCGTGGGAAGTTTTATTTCATGAAGAATTTGAGCCTGAGTTCTATGAACTTCCTCAAGAAGCTCAAGATGAATTGCTGGCTTATGCAAAATTACTTGAATGCGAGAGTCCACATCTTAAAAGACCTCACGCTGATACACTCAATAGTTCTTCGTATGACAATGTGAAGGAACTTCGGTTTAAAGCGGCAGGTGGAGTATGGCGAGTAGCTTTTGCTTTTGACCTAAAGCGTCAAGGAATTTTACTCGTGGCTGGAGATAAAGCAGGAACTAGCCAAAAGCGATTTTATAAACAACTTATCGCAAAAGCTGATAAACGATTTGGGGAACATTTAAGTCGATTGCAAGAATAAGGAGTATTGGTGATGGCAAAGAATCTCAATGAAATAATGCAAAATCTGCCACGCGATCGCGTTCAAAAAATCGAAGCACGGGCAGCTGAGTTAATTGCTGAATATATGACACTTCAGGATGTAAGAAAAGCAAGAGAACTTACCCAAGAGCGGATGGGAGAATTATTGGGGATTCGTCAGGATAGTATCTCAAAGCTGGAAAAGCGTACCGATCTTCTGCTTTCAACTCTACGGGGCTATTTGAATGCAATGGGAGGTGAGCTTGAACTGGTTGTCAAATTCTCCGATCGCCCACCTGTTATAATTACTGGGCTTGCAGAGCTTGATGATGAAGATTACGAAACTTAATCAAAAATATGCAACAGTTAGGAACGCCAATATCGTTCGTAGGAATTGATGTATCCCTCGTGACTGTTTTATTGCAGGAAGAACACCCCGATTTAGCACACTTACCGATTCATCTGGTTGATGCGGGTTGGGATAATGCCATATTTCGATTAGGTGAGGATTTATCGATCCGACTTCCCTGTCGTCAAGTTGCAGCTAAACTCATAGAAAACGAACAAACTTGGCTTCCCAAACTAAGCGAAATCCTGAAATCCACCTGTTTTATTCCGTTTCTTTGGATATTGACGATATCTGCGAAATCTCTTGATATTATGACTAAAATACTTGTAAATAAGAAATAGTTGGGTCAGATGAGCTATTTTGTCGTAATTTCTGGCGAAGGTTGTTGTGCTCTTCCCATAGCACGCGGAATTATTGTACCGATCGAGACTGCACAGGATTACGTCAGCAGTCTAGCTGGGCTACTCACTGCCATCGATGGGCAACCTCTCTTCTTCTGGGACGATGGAAAGACTGGGACTTCTCACGAGATTGTATGTGAAGCCGAGAGTGAAGCCCAGATGATGCTCTGTGGATTAGAGATACTACAAGTCTGTGCTTTCAGTAAGGTTCTAACAGACAGCGATCGCCTTGGTTGCCGAATTCGTGTTTGGTGGGCAAACAACGATCCGGAAGCATTTCTCCGTGTTCCTTGTGCTGAAGGTGCGCTTGATGCCGCTCGAATTTCCAATCGCCAGGTTCAAAACGGCAACAACATAGAATTTGTGATGCGACCAACTATGTGTTGACGAAATACTATATTTCCCATCACTCTCCAGGTTCATCTTCAAATTTTGACTGATTTTTATAATATATTGGCGATCGCACGCAAATGGCTTGATTGTTCAGCCTCAAGTTAAAGTTAATTTCCGGCATACTTTTTCTGCTTTGATGTAGAAAGCTCTAACACCATTGCAATGTCGGCTCTTATGCTGCATGACTGCTGTTTGCACAGAAGATTCTCGCCCCTTTTCCAGTTCTCAATATCAGCCTTTAATTGATGATATTGCGATCTCTCTTACATATATTTAAGTGGGTTAAAGAATTAATGGAACTGGCACAGCAAAGCGATGACCCGAAAATAAGAGTATTAATAACATCTATCTCAATAATAATTCCCGCAAGGAATTCCACTCAGGTAGCCACATCCAAACATCTTCAACTGTTTCCTCGATTCCTTTAAGGATACTGTCACGAAACACAACTGGGGATTGAAATCCAAATCGAGAAAGTTCTTCCCGCATCCCATAAAGCAAATCTTTACCAGCAAAAAAGGTTTTATAATTCTGATTTTGAAATCGACTACCACCAGGTTTGCAAGTCGGCAGCAACCGCTCGAATTCTTCGTTGGGATTGGGTCTAGGTGAACTAAGCCTCTGTTCGTATTGTTTGATAATATTATTTAATTCTGCTTTACAGTTAACCTCTGTCAATCCTGACTGCCTGACAGAACTCTGAAAAGCCTAGCAAAATCAAGGATTTTAGTAAAAAAGGTCGAGAGACATGAGATGGTAAAGTTACCAGACTTCTACCAAAAAATACCATGTCAAACTCAACCCAACTTTATAGTCAGGTATTAGGATACTTACGTCAATACAGTACCTACCGTGATTTGCGTCATTTAAAAACTCTTGCTTGGATGATTAATGGGCTGATATGTAGTGGTCAGTTAAGTTTGAGCGCATGGGAACCATATGTAGACAGTTATGCCAAACAAGCTCAAAGCTACGAGCGCAGGTGGCATAGATTCCTTGAAAATATAAGGATTAACGTTGAAAAAATATACTTGCCATTGGCATTGTTGGCACTCAAAGACTGGGAAAAACATCGATTGTATTTGGCATTAGATACAACTATGCTTTGGAATCGTTTCTGCATGATTCACATCTCAGTGGTGTGTTGTGGGCGAGCAATCCCTTTATTGTGGAGAGTATTGGAACATAACAGTGCAACGGTTGCATTTAAGGAATACGAGGTGATGCTACGTAAAGCTAGGTGGTTACTACGCCGTGATTCCGATATTATGATACTTGCAGATAGGGGCTTTGCAAATCATGATTTCTTGAGTTGGTTGCAAAAAAGCAATTGGCATTACTGTATACGTATCCCAAGTGATACATGCTTGCATGGAGTTAGACGTTACCCAACACATGTAAAATCAATTTATCCAAATCGAGGACAAGCAGCTTTTTATCGTAACGTTGGACTGTGGCAAGATTGCCTAATTCGCTGTAATTTGGTAGTCGCCTATCCAGAAGTGGTATCCGAGCATTGGGCAGTTGTTACAGACGAAGAGCCAGCTTTAAAAACATTGCATGAGTATGCTTTGAGGTTCTGCGTAGAGGAACTATTTCTGGACAGTAAATCAGGTGCATTTGAACTCGAAGATTCTCGCATTCGTGATGCCGAATCTTTGGAGAGATTGTATTTGATTGCCGCCTTAGCTTTACTTTACAGTACAACCCACGGCATGGCTGTACAAATTGCTGGTTTACGTACTTGTGTTGACCCCCACTGGAATCGTGGTTTAAGTTATCTCAAGATTGGTTTGCGCTGGCTCAAAGGTGTTATTCACAAGGGACGACAATTACTCACCCCAATTCCTTTGTTATCACAAGATCCTCAACCAAGTTTTGCCTCCAATAAAGCTCGTCAAGATGACAATCTCGGAATATGCTTTTCTCGAATTTACTCCTTTAATTCCTGGGTTTGACTGCTTTTCAAACAAATCTGTCAGGCAGTCAGCGGTAAGGCTGTTGTTCGCTTCCTTGAACTTCAGCTTGAATTTCTTCTCCCCGTTGGGTAACAGATAACACTGAGCCATCGCGGTAGCATATCTCACCTCGTTGAAATGACTTGGAGTTTGTGTTGTGACGAATTATGGATTCACTCAGATTTATGCCAGACATTTCACACCCCAAATAATTATATTGTCTAGGATAAAACGATTTGAGGATAGCTTTGATTGCTGCTCAAAAAAAAGCAATATTTACTCGTTTAGCAAATTTAATGTAATTCGTAAAAAGAATCTTTTTCTAAATGTTGCATGTATTTCTCGACAAGTGTTGGAAGAGTATCTGGATATCCGATTCCTATCCAGTCGTCGATAGAACCTAAAAAACAAAATCTTTGCGCTGTAAATATTCGTTTCTGCTCATTATAGAGAATAAATCTTAGCATTGATGAGTATGAAATAGAGCGAGCGATTGTAGTTTCTATATCTACTGGGTTAGCTGTGGAAAAAGATGAATAAAGCTTTGATAGATTATTTACATTTTGGTTCGGGGTATAGACATATATCGTGTCCTTTTTTACATCTATTTTGCAGTAATGTAAGTGGGAGAATTTTTGAATTCCTTTCTCTACAGTTGCAATTTCGTCTAGGGTAATAATTTTAGGTTGGATTCTTTGTAGGAAAACCTGAGCGTTAGGATTTTCATAGACTTCAAAACCATCCGGTATTGTTTGAACCAAAGTTCCTTCGCTTTTCTGAGAAAAGAAGTATTTTGGTTTTCCAGTTTTAGTAGTACCTTGATGGAGATAGTATTTTTGACCTTTTCTATTGATATGCTCTACAGCCATTAAATTATGTCCTCTGGCTAAGTTTATATATAATCCAATAAAGTGCTAACAGTATATTTACATATCATCACAAATGGTTACAACATCAATCAATCCCTATCTTGATGGAAACTTTGCACCAGTAGACAAAGAAATCACCACTGACACTCTCAAAGTCATTGGGGAAATACCTCCCGACTTATCGGGTATGTTCGTGCGAAATGGTCCCAATCCGCAATGGACACCCATCGGACAATATCATTGGTTTGATGGGGATGGAATGTTGCATGGTGTGCGAATTAGCAACGGTAAAGCGACTTATCGCAATCGTTATGTGCAAACAAAAGGATGGAAAATTGAACGGGAAGCGGGATTAGCTGTTTGGAGTGGGATGTTAGAACCGCCACAGCAAAATAATCCCCACGGTTTCTACAAAAATGCTGCAAATACTGCTTTAATTTGGCACGCTGGTCAATTTTTGGCGCTGTGGGAAGGTGGTGCGCCTCACCACATTCAGATTCCCAATTTAGATACAATTGGTGAATATACTTATAATAGTCAGCTAAAATCAGCTTTTACAGCACATCCCAAGGTAGACCCGGTAACGGGTGAGATGATGTTTTTTGGCTACTCCTTTGCACCGCCATATTTGCAATATAGTGTAGTTTCTGCGTCGGGGGAATTATTGCGAACAGTACCGATTGATTTACCGATGGGAGTGATTATGCATGATTTCGCCATCACCGAAAATTATACAATTTTTATGGATTTGCCCTTGACTCTTAGCCCCCAACGGGCGCAAAAGGGAGAACCAATGATGATGTTTGAGCGCGATCGCTCCAGTCGTTTTGGTATTGTCCCACGTCATGGCGATAACAGTAATATTCGCTGGTTTGAAAGTCCTGCTTGTTATGTCTTCCATACCCTCAATGCCTACGAAGAAGGTGATGAAGTAGTGCTAATTGGCTGTAGGATGAGTTCTACTAACGTTTTAAGTACTAAAGATACACAATCTGACCCAGATGGAGATATTCCCCGCTTACATCAATGGCGTTTTCATCTCATCACAGGGGAAGTACGCGAACAAATGTTAGATGATGTACCTGCGGAATTCCCTCGTGTAAATGAAAATTTCTTAGGAAGACAAACCCGATATGGTTACGTGGGCAAAATTGCACAGGGTTCCATGCCTTTGTTCGATGGTTTAATTAAATATGACCATGATAATGGCAAGTCTCAAACCCACGAATTTGGGCAAGGACGTTATGGTGGTGAAGCTGTTTTTGTACCTTTTCCCAATGCGACATCAGAAGATGAAGGTTGGCTGATCACTTTTGTTTACGATAGCAAAGAAGATACATCTGAACTCGTGATAGTTAATGCTCAAGATATCAATGCCGAACCTGTAGCGCGGGTTTTAATTCCCCAACGTGTCCCTTACGGTTTTCATGGAGCTTGGGTTTCTGAAGAACAGTTGAGTGCTTCTGTGTAAATTGTGTAAATAAATATCGCAATTTTGTTCCCATGCAGAGTCTTGGAGGAAGTAGATTGAATCTCAGTTAAAGTATCATTTTTATCTTCCTCCTCGAAAAGTTCCACCAATTACTTTCTCCAAACTGTCGATGAGATAATTTTAGCTTCCACATCATCTAAATAAAAATCATAAACAGGTTCTCCAGATAATTCACAACGAAGCGGCTCAATAATTTTACTAAACGGATTCCAAACTACCGTTACAGTTCGTCTTGCCTTCTTTCTTTGCAACTCACACTGAATATGTACCGTAGGTAAATTGATAATCATTGCACTGTGCAAGGAAGCTTCGACACTCATTGCATAACGTTCTTGGATATCTAATAATTTTCTTTCTAACTCTCTATTAGTCGCTTCAATTCTGGCTAATTCCTTATCTTTTTCATCATCACTCAAATGTTTTAACTCAATCTTGTGGCGAATTTCTGAGCTAATAGTATTATAATAATCCTTCAATCTTTCTTCATCCCTAGCTCTAGCTCTAATTAGTTTAGCCTGCCAATTCTCTAAAGATTTTCCAATCAATATTTTACTTTGATGCTCAATTAACATCAACAACTCATTAAAAGGTATAGATAATAGACTTTCTTGATGCTCCACATCAATTCTGTCAGACTCCCAAAACAAAGCATCCCCAATTTCTACTGGTGTTACTCCTGTTAGTTCATTGATCATAAACGAAACTAAACCAATCCTTTTTTCCTCGGCATTCGCCGTGTAAGCCACATTACACAGGATATAGCGAGTGATTTCTGGTTTCGCATCTATAAAACGCATTAAACCATTTTGAACTACGAATCTCTCTGCTATACTCTTTTCAAATCCCGTAGTTTTTAAATAACCATCAAATTTAATCCCCAAGGTACTAATCAGTCCTTTAGTAGCTAAAAGCTCAGATAACTTATTTAAGACTTCTGAATGATAGGTAACGAAAACGCTTTGAGGGACATCTGCAATAGTTGCAAAAGTAACTTCCTCGGAAAGGGAAAGTAGGGATGCGATATTTTTTGTTAATAATGCATTTAAAATGTGTTCACCAGCAGGTTCTGCAATTGAGTCATGTAGAGAAATAATTTTTTCTAATGTAGCAATAATTGGATCTGAAATCATAAGTAGGTTGACGTTGAAAATTGTAATTAGGAGAAGGCAGTAGGCAGTGGGCAGTAGGCAGTAGGAATAAGGGTTTAAAGTTTACATTCTGTTTATTTCTGCCGACTTACTTGTCTAATTAAATCAATTGATTAAGCTTCAAAATCTTCGCCAAAAATCTGTTCATCCAGTTCTTGAACCTGCTGATATTGGTTTTTGGCGTTCAATAAATTATCTGCCAATTGCTCAAATGCTGTATCTAATTCTGGTTTGACTTGATGCTTCAGCCAGATATCCATGACAATTTCACTAAAGTCAAATTCATCATCCACATTCCCCAAAATGGTTTCAATCTCTCCCACTACCAGTTCAAACATATTAATTTTATCGTGCAATATCCGCAGAATATATTCTTCGATACTGCCTTTGAGACAAAAGTTAAAAATAAAAACATCCTGGGTTTGTCCGATGCGATGAATACGTCCAATACGCTGCTCTATTTTCATCGGGTTCCAGGGTAGGTCATAATTAACAATCGCATTGGCAAATTGGATGTTACGTCCCTCTCCCCCTGTTTCCGATGCTAAGAGTACAGAAACATCATCCCGAAATGCCGCTATAGCCTCATCTTTTTGTTTTAGGGACATCCCACCAGTAAATTCTGCAAAGGGGATATGTGCAGCTTGTAGGGTTTGGGCTAAATAGGTACTGGTTGCTTTATGGGTTGTAAAGACTAAGGTTTTTTGGGAAGATTTAGAGAGCATTTCTACCAAGGCTTTTGATTTTTCCACCTGCTTAACTTGGGATGCTCGTTTTGCTAAGGACTTTAATTCTTCATCAGGTAAGCGTTTGCTTAGTTGTTTGAGGGAGTCAGCCAAAGCACCAGGGGATGAACCAGCACGCATCAGCAAATTGGTTCGGGAAAGTCTATCTAATTTGTCTGCTGCAACACGTAGGTACTCACTCAAGTCCTGGTAAAGTTTCTCCTCACCTGCTGCTGGGGTAACGGTAATTGTGGTGGCAAAGCGTTTGGGCAGTTTGACATCTACTAAAGCGCGGGTATTACGTACCATGACTTCCCGCATTAGGGAGCGTAATTTTTCGGGATTTTTCGGGACTCGTCCATTTTTGGAATCGACGTATTCTTTTTTAAAAGCGGCTTCTGTTTGTAGTAGTCCTGGTTTGAGGAGGGTTAGGAGATTAAACAGTTCCACAAGGGAGTTCTGTACTGGTGTCGCGGTGAGCATGAGGATAAACCGCTTATTGAGGGCGTTGACGAGTTTCCAGTTGAGGGTGCTACGATTTTTCAGGTGGTGTGCCTCATCAACTATTACTAAGTCCCAAGTGCGATTGGTGACGTGGGGATAATGTTTGGCAGATTTAGCTGTGTTTAATGAAGCGACAATTCGGGGATTATCTGTCCAAAATTCTTCTATTGGTTGTTGGGGGTCACGGTTATCTGTGGTGATGGTGGCGATGTTAAATTTGTCACTTAATTCTGATTGCCACTGGGAAACTAGGGATGCGGGAGTTAGGACTAATAGGGACTGTACCATACCCCTAGCTAGGTATTCGGCGATGATGAGTCCAGCTTCAATGGTTTTGCCCAATCCGACTTCATCGGCTAGTAATGCACGTCCACCTAGTTGTCTGAGGACTTTTCGGGCTGTTTCAATTTGATACCAGTATTTGTCGATGGCAGTTAGTGTGGGTAGGCAAATTAGTTGATCATAGTCTGCCATGACTGAGAGGTTGAATAGGTCTAATCGTGCTTCGTAGAAGTTGATTGGGTGGTATAAACCAGCTTTCAGGGCTTCACTGGCGGTGGAAGAGTTGAATTTGAATGTATAGTTTGTTTCCATGATGCACTCCTACAAGCTACTTTGGCTATCTGACAGTTTCAGCAGATGAAATTGCCGAGTGTTTCAGTAATTAATAGTTTGACATGCTTTGTTGACGCTGTTGGTGTTTAACTGCGATGTCTTCTCAACGGCAAGCGCAGCGATCGCAATATATAACTATTCGTGTATCCCAATCAAAGTGCCAGGGCTTTTCAATCGCTCTAAGCCGATATTTCTAAATGCTTGACTTGCTGCTCGATATCACGAGCGTAGATTTGTTGTTGTAGCAAAAACTCCACTAAACCATTTATTCCCCCTTGGTTATAAACAGCAGCGTAACCCTTGATTTTTCTATTTTTACAGAAATCTCGCAGTTGACGCACACCCAAAGCTTTGAGGCTTTCACTTTCTCTATCAATATCAAACAGCGCAGTTTTGCTTTGTTTCTGATCAATTGTTGCTGCCATATTAGCAAGCAACTTATCAATGTTTGATTCATCTGCTGGATTGAGAATATCTTCATCAATCTGAGTTTTGATGACACCAGAGGTAAATTCTTCATCTACCATTGGCAAATTGTCATCAACCAAGAAAATCTCACACATCAACCAAAAGATGACCAGAAACAAAACAATCGGAAACAAGATATTATTGAGTAATTGAGTGGTAGTAGAAATTTCAAAAGCCGAACAATCAAACAAAAATTCAAACATTGTAGTTCCTCCAGATAATTATTGGGTGATTTGTAGATATCACCCAGTAGCGGGGAGATACCTCCCCGTACTGAATGCATCAGACAAATCATCCCGACAATCCTGAAGTCAAGAGAGTCTTACTACCATAAAGGTAGTAGTAAGACTAAATTTTCGAGATTTTGCAGTAGTTTCAAAGAGATAAATTAAGTTAGCAGTAAACCGAATCCTTGGTATTTCGATAAATTGAGAGTTAGAGCCTCACCCTAGCTTGATTAACTTTCAGCCATTCAATAAAAGTCACAAGATTGTAATTATATTTGAGTGATTGCGGCACAATTGATTCATAAGGATACAAAGGAATACCATCAAAACGAAAACGGTATTGTCGTTCAATATGTATATTGAGTTTCGGGCAATAATTAACCCTGACATTAATACCAGAATCGCTAATCTCGACGGTAGCAATACCCCGCAATTGTTGAGCAAATTCATCAACTTTTAATGAATAATCAAATTCAATTACAGTCCGGACTGAAAAATATTGAATGTAATCAAGTAATCTAGCATATTCATCCAATTCTAGAAGTTTATCAGAATCATTAAGTAGAACACCAGACCACGAAAACTGAAATCTACGATTGGTATGATCATCCCAAAGCGTTAAAGTCCCATCATCGTTTTTAAGTAAACTAACCTGATTTGGCTGAATACTACAATTTAACTGGGAAATAACTTCTTCACGCTCAAATGGAAAATAAACCCTTTGACGACGTTGATTTGATTGCCAATCGGGACAATTATCATCTTGTTCCCATCCATAAGGATGCATACCGCAAACAATTTTATTTGCACCATGAAAATTGCGACATCCTACACATGTTTCTAAATTAAAACTAGAAAACTCCTCACAACTAGATTTAAACTCTAATTGAGGACGATAGAAATCAACAAATTCACGAATTGCATGATTAGGATTTGGGTTTTGGCATGAAAAAGCTTTACCAATTAGCTTCTCCTCATCATAACCAAGATCAAATAATTCCATCAAGCTATCTTGAGAATCAGAATCTAACAAATCGTAAACAACAAACTTTCGTGATGATTCATCTTCAACTCTGCCAACAATCAACTTATTGTCGAGGTGACGACAACCTAGAATTCGCATTATCTGATAGAGATATAACGAATCAGTATTATTCTGAGTTGGGATACTCTCACTCGACTCAAATACCACAGAATTAGTATAACTAGAAGTTACAGATTCCTCCCCATCAACCGCACCTGAAATCGAAGCAATACAAGCAGCAGCTACAGTTGCAGATACAAATCCAACACTTCCTAGTAATGTAAAACCCATTCCCAGTTGTAAGGTTTGTTGAATGCGTTTCTCTGGTACGGTTTTAACTCCAGCTTTATTAAGACAAAGCAAACCAGCACTTCCGAAAACTGTTATAGCACCAACCACAATTGTAGCTAAAGAAGAAAATCCCACTGCTACATTAATTGTTCCAAATGCTTGACTACAAAATCTCTTAAACATAGTATCCCTCTCTAATACGGGTAACAAAAGCAGAAATTACTCTTGCCCCAGCAGCTTCAAATTGGGATTTGAGGATAATAATTAACCTACACCTTACTTGATTCTGTTGCAGAATTTAATGAATTCTGTGTGAATATTTTCAGTATCGGTAATCATTTATCCCCAATGGTGATAGTAAGAGTTGAACTTACTTTATTGCTACTGCAATAATCCACCCATAGAAATATCACCCATTAAATAAACTCTAAGTATTAGTTGTTGTTTTTAAACATATATTAAAATCAAAACTGTCTCTTATTATTATTCATATCTTTAATTCCTAATTGAGTAAATTTATAAAAGTTCTCTAACAAGAAATCTGGAGCAGAAGACAACCTTAATATCACTCCATCACTTTTAGCTCGATAGTAATAGTGAGGCACAGGAGATTGAATTATGATAAGATTGTCATTACGAATAATTCCAGCATCAACCAAACCATCTAAAATATATTTACTAGCTGCGGAGACATTATCACTATCACGGGCAAAGGTTTTTAAATGCCAGTGATATTCAATCCACACCTTATCATTAAAACTAAAATCAACTTTTTGAGTTAAATTAGCAACTTTATTAGTCCAAGTTTTCTTGACAGCAGCACTTGCTCTCCAATCCGAACGTGCTAAATCAATTTGCTCATTTAAAGCTGGTGGAAGCATGTTGAATCTAAGTTCAAGTATCATTATTATCTTCCTCCTCTAAATTAGCAATAAATTCAGCGATAATATCTCGAATTCGCTTATATTTTCTGCCATCAGCACGGGACAAATTAAATACCTCCTGGACTATTTGATGTAGTTCATAACCTCGACTGTGGAGTGAATAAATTTGAGACTTAGTTAAATCATCAATGGTAATATTAAAAGAAAACTCCTCCGAGTGATTATTATTAACTAGTGAATCAGTTGTCAATTTATTTAACTTTGTCCGCAAAGTTTGATTATTAGAAGAAGTTTCACCTTTAAGCTCAATATTAAAACTCGAAAAGTTCAACTTAGAATCCCAACAAGGACTATTATTTCCCGCACTCATTGCTTGATCTAAATACCCTTTAAAAGCAGCTTTCGTACCCAAATATAAACCCTGAAGACGCATCACACCTTTGGGAGATTTATACAGCATATCTCCACCACCCAATAAACTTGCTGCGCGATCATCATCGGGATTACCCAGAATAATCCCACTATCTTCAGGACGAGACACCATAAAAGCAACCTTGCCCGAACAATTTGAGCGAATCAAAGGTTTAATCACATCCTTATCGGGACGTTGGGTAAAGAGGAAAATATTGATTCCCGCAGCACCGGCTTTTGCAAGTAATTTCATCAAAGCCATTTCGATTTGGTCTTTGTAGGTGCTATCGGATAGTAAATCAAAGCACTCATCTGTTACCGAAATAATTCGTGGCATGGGGCGATCGCAAAACATTTGGTTGTACTCGTTAATATTTTCAACCCCTACTTTTTTAAACTCTTGATAGCGAAGTTCCTCTTCTGCAACCAAATAATTGAAAATTTGCAGGGTACTAGCTGCATCCTCGGCAACTGGTGCAATAAGATGAGGAAGTCCATTAAAGCAAGTTAGGGAAACCAGTTTGACATCACTAAGGGCAAGTTTTACCAAGCTGGGAGGGTAACGCAGTGCTAAATACAGAACCATCGCTTTTTCAAACTGGCTTTTTCCACCACCAGTCATTCCCCCTCCTAAAGTGTGGTAAACATTTGAATCGCACAAGGAGATTTCGATATACTTACCATCGACATCCACACCAGCGGGGATGACGATACGGTTAATATCAATCTCACTTTGCAAATCAACATAATCTGAGAAGTTTGCTATTTGGCGATCGCATCTGGGAATATCAAACACCACAGCACCGGGTATAACAGATATCATCGGTGGGTTATCAAATCCAAGTTGTTCCCCCAATTGTTGAACCAAGTCGCTACCAAGTCCTTGAACTTTTTTGAAGCTAACCCCTTTCCCTAGCTTGATTTTGATACGTTTGAAGGTGGGACCAGTTTTGGTATCGATATAGCTACAGGTAATGCCAAAATCATTCAGGGTTTCGACCAAAGTATTACCCACTTGGGAATTAAAACTTTCTTGAACCAAAGTAGTATTTTGAGCGGTATTTGCAATCGCATTATTCTGTGCAATACCTTTCTCAAGGGATAGAGATGGAATTTCTCCATTTTTCTTTGCCACCAATTCTGCTGTTTTATAGACAAGTTGTTTCAAGTAAATGTTTTTAGTTGATTCAGCTATTTTAATTAAATCTTGGTAAGATTTAATTTCTTGATATTGTTGATATAGTTCAATAATAAAAGCATCACGTTCATATTTACTGATATATCGATTAGTTAAAATATATTCCAAAGCCAACTTAGAAAAAGCCAAATCTTCTAGGTTTAGTTCTTCCGAACAAGCATCGATAATTTGTTCAACAGAAGTCCCACTAATTACAGCTTGGTAAATTATTTCAAATAAATAATTATGGTCATAACTCTTGATAGGTCGAATAATTTTGCTACCAAAGTCAGATTCTTGAAGAATATCGACAACATATTGCTGTTGACTCAAATCGAATACTTGTTCTGCTTCTGTTAGAATTTCCTGGTTGGATAATCCTTGTAACTTGAGAGCATTAACAGCACAGGTGATTTCGGCGTTATCATAATTTGACATACTCTCAACCTCCAACAGTTAACAATTGCTGTCGATAATAATTATTTAATTTCTCCATACTTTTGGGATTTTGGTTATAAGAATTGCAGGGAAATGAAGCCCAGATTTTACCGACTTTACATGCAGCTTTATCAAAATTGCCTGATTCAACGTCTGCGATCGCACGATTACGCCGAATATATTCCACAGCCATTCTGTCCTGAGATACGGGTGAAAAATCAGCCAACTTTAACTTTGGTTGTAAATCCCACCAAGACTTATCCAACATTTGATAAGCACCAGCAGCAGTCGAGCAAATTCGGTTGCCATTAATTGGCGCACATTGTTTAATTAATGGGTGTGTCGAGAAATCATTAAAATTGCCATTGAACACCAATTTTCGATAACTTTCGGTTCCACTATTTCCAGTTTCAGCCCAGCGAATAGTTGCTAAAAAAGCTTGCATTCTCGGAGAATATTTAGAACTTACTCCAATATCAGTCTGATGAGAATTAGTGTTAAATCCAAAACTTTGAGAACCTAACAAACAGTAAATACCCAAACAGGAAACAGAAGCCAAAGATAAATGAATGGGTTGAATTCTACTCTTCATACGACGATAATCAACTCCAGAAACTAATCCAAATATTCCACCCAGAATAAAACCGAATTTCCAACTATCGAGAGAATTAGTAAAAGCGCGAATAAAGCATACTTTATCAGCACCGGGAGAAACTAAACCGCATGGAACAGAAGCAATTCCGTAGTTCATGGCAACCGAACTCGCAGCACCAATTAATCCGGAAATGAAGATTTTCACTAACATATTACCGACCTGCTAAATACTGTTGCAAGTAAGGACGGGGGTTAACAGGTTTACCATTAACTCGAACTTCAAAATGTAAATGTGGTGCAGTAGACATTCCGGTACTACCTACTGCTGCAACCATCTGTCCCTTTATAACCTGCTGTCCTTCTCTCACGTAAAGCTTGCTTGCATGACCGTAAAGCGTTGATTTTCCAGCGTTATGATTCACTACTACGGTGTTCCCATAACCTCCTTTTTCTCCAGCAAGTTCAACCGAACCAGCATCAACCGCATAAATTGGAGTACCCAAATCAGCACCAAAATCGATACCAGTATGGAATCTGCGTTCTCCGGTAATTGGATGAATTCTCCAACCAAATCCGCTTGTTACAGGAGCGTTTTTGACAGTTGGGAAAGCTATTCGAGCATCCCTGAAGTCAGTTGTGTTAGTTGTAACAATTAGGTTTTGGAGTGATTTGACCAAATATTGAGATTCCACCCAGGAGGAGATTTGGGGAAGTGCGATCGCTAGAGTCAAGAAAAAGCTAGCAAAGGCATAGTGCCAATTTGCATCATTCGAGATGCGATCTAATTGTTGATTATCAACAGTTTCATCCTCATTACTGGCTTTGGTTCTATCGATTTCCAGCTTGATTCGCATTTTGACAACTCGAATTAGTGAAACTTAGCAACTTTTCAAAATTGTTCTTGGGATTATTGCAAATGGGTGCGACTCTTTTAGTAGTACAAGGTATGGTATAAGAGTAATAGGAGACAAGTCAACCAGAGTAATGTTTCAGTGCAAAAATGAAACAGATGCATCCTTGCTTGTCAAAAGATAAAAACGGGAATAAGTACGGACGTATGCAAGCATCTAGATCAAATCCAGGGATGTTTTGGGAAGAAGCACGAGAACTATTTGAAGAAATAGTTGGTTGGCTGGACTCAGATAGTATTTGTGGGTTGGAGCATGGAGAAATAGAAAGTAAGTTGCTTGATAATGGATATGAACTACTTAGAAGGCTGTTACAAGGATACTTTGATAAGCGTAGCCAAGACGAAACGGATTCTGAGTGGGTAGGAAAAGACCAAGCCAAGCGAACGCACAAGAAAAATTGTCAAGGAAATTAACAACAATATTTGGCACAGTAATCGCAAACCGAATCGGTTACGGAGGTAGAAAGATAAACACCCTATTTCCATTAGATGCAGAGCTAAACCTACCAGCAGAACAATATTCTCACGGATTAAGACAACGAGTAGCAGTGGAAGTAGCTCGTTCAGGATTTAGGGAAACAGTGGATATTATCGAAAAACAACAGCAGCCAAAATTGGTAAACGGCAAGCAGAAGAACTAGCGTACCAGAGCGCTGTCGATTTTGATGATTTCTACACATATCAACAGGCAGAAGCGGTACAAGTTGAGGAAATAGGAGAAATTGTTGTAATCAGTGCAGATGGGAAAGTGTGATTGTGAGCCACTCGACACGGGCTGTGCCCAGTGTCGAAGTGGCGGTGCGTACAGAGGATTTACGTCCCCAAACCCAAAAACGAGCGCAAGCTTCCAGCAAGAAGTTAGATAAGCGTTTAACCAAAGGAGAAAAAGCCAATGCCAAACGAATGGCAACGGTAGCTTCAGTTTACACAATCAACCCGTTTGTTCGTACAGTTGAGCAAATAGTTAACCCATCCGATGAGGATAAGAAAATAAAGCGTCCTAAACCTATTGGAAAAAGGGTTTGGGCTTCTGTTGCCAAGGAACCAGAAGTCGTCATTAAAGAGGCTTTCGATGAGGCATTGCATCGTGATCCAGATCGGCAAAAACGCTTTTGTGCCTTGGTCGATGGTAATAAGCAACAATTATCGTTGATGAAGAAATTTCCAAAAAACATCACCTCGAACTGACTATTGTCCTGGATATTATCCATGTGATTGAGTATTTGTGGAAAGCAGCATTTGTATTTTATTCCAGTACGGATAAACAAGCCGAAGCCTGGGTTACGAAACGTTTGAAGTCTATCCTTGAGGGGAAATCCAGTGATGTTGCTTCTGGGATGCGAACAAGCGCGACAAAACGTAAACTCACACCCCAAGAACGCAAACCTGTGGATAACTGTGCCAGATATTTGCTCAACAACCGCGAATATCTCAAATACCATGATTATTTAAAAGCTGGGTTGCCAATTGCTACCGGAGTTATCGAAGGTGCTTGCCGTCATCTGATTAAAGATCGGATGGATATTACTGGTGCCAGATGGAGTCTAGCTGGTGCCGAGGCTGTTTTACGGCTTCGTTCTTTGTATATTAGCGGGGATTGGCATAAGTATTGGCGCTTCCATTTACACCAAGAGCATAAACGCAATCATCTTGCTCTGTATCAAGGTGCAATTCCCTTGATGAAGCGAGTTGCTAAAGCCCGTTGCCCTATTACCCCTTCACCCCTTCCAATACCTGTCTAAACTACATTTCCTGTCTTACTAAAAGAGCCGCACCCAAATTAATTGGCATAACAATACCTCTGCCAAATTAAGAGGATTCAACGCCCGTAGAAACGTGATGAATACGCCCTAAAGAAGTAAGCTTGGCAAAAATCCGGGTTAATAAAATAGGCTCAGGGATTTCTGGAAGCATTTTTAAGATCTCATGGACATATCGAAAGCCACGATAATGAGCCTTAAGATCAATAATGCCGGAGTCAGGATTCAGGATGCGGAAATCAGCGAGAAGATGATGAGATAAATTAACCATAAAGAATGCTAGATTAGCAGCATTAGTCACCGCAGTTTGACCGATGTTCATAAAGTCTTCCAATCCCCAAAATTGCTTGGCATCACGGAAGTTAAACTCGATCTGAAAGCGTAGTTTGTAGTAGTCAATTATTTTCTCAGATGACAACTTTAGGTCACTAGAAAACAGAATTACGTGACTGCGAGCATTAGTTTTCAGATTTGTTTTCACCAAAATAACTACATTCAGGGACTGGGCAAATTCTTTGTGCAGTAAAGTAGCTTGGTAACTATCGGTTTGGATATCCTCTTCGATACTACTTTGACGCAAATATTCATCAGAAATATTACGCCAGTCTAGTTTATCTCCGTATTTACGGCGTGAACGATGATTAGGGTCAGGATTTTGGTAAGGTATGTATAATGCTGAATCGTGGCGTAACTTGGAAATTATATGTAAGTTGACCTGTCGAGCCATCTGCAAAGCATTATTGTTTCCAAAATGACCATCTAAGACTAAGTAAGTCAGTGGGATAAAGTTAGCTACCAGCTTGACTAGCTCATTAATCATCTTCTTAATTCTGAGTAATTCAGATGTGAGAATTACTTCGGTCTTGTTTTTATTTTTACTCCCTTTTGGTCGTCCACGTCCACGTTTTTCTTTGGCTTTTATTTCTGGTCTTGGCGATACACTACTTTTTTCTATATCGTTCTTTATTACCTGTTCTATTTGAATCGGAAATGAGTGCCTTTGTTCAACACTTACTAATGATAATGTAAAGAAAGATAGCCCTGATATTGGCTTACTTACTAGGCTGGAAAAGAATCTATCCAACCCATAAGTTTTTTTCCCAGATTTACTTACTACAACTTCATCTCCTGCAAGCAAATAAACCTCATTTGCACGGAACAAATGCTTGCGGAAAAATAGCCAAAACAATGTCGCCCAAGGGATTACCGTATGAAAAAATCTCAACATCGTCCGATAACTACCACCACTACCTGTCCAACGAGAAATTCCCAACATAGTGACTCGCCCGCTCATCGCTAACATTGCCAAGATTATTTGGTTCAATTGCTTCATCGTTGTAGCATTTATCTGCGGCAGGAAGCACTGTAACAATGATAAAATGTCAAACATGGGCGCACATAGTGGTTTTTGAGTTGTCGTTGTGAGAGACAATAACTCTACTACGAAACGCCCTACCTCTTCCTCTTCATCCTCTTACTTTGGCGAAGGTATTGGCATAAAGTACGAGATTATTTAGCTGATCCAAAAGAGGGAAGAGAATTAATAGAGATGGTGATTTATCTCGGTTTGCCTCCCGCAAAAGAAAGATTTGAAGAACAGCGAAAAAGCAAAGAAAAATTCATCTATTGGGCAAAAAGTAATGGTTTTTTAGTCGTAACCAAAGAAGGTAAAGCGAAAGGAGATGATTACGAGAATAATGTTGATGTAGTGATGGCGATAGATGCAATTGAGTTAGCTTTAGAAATTAAACCAGATATTGTGGTTCTGGTAACGGGGGATTCTGATTTTGCTTATTTAGCACAGAAATTGAGAAGACGTGGAATCCGGGTTGAGGTGGCTTCAGTCGAACAGTCTTTAGGAAGTGATTTAAAAAATTCAGCTAATAGCGTAGTGGATTTAACTGAGGTGTTTGATAAATTTGACCAGCATGATACTAACCAAAATTATCACCGCATTGGTAGTTATAATATCTTTGATTAAGGAAGGAGTTCTTCATGGGGACAGTCAATGGCAAATTAATTAATCAAAAAATTAATCATTTTGATGAACTTACACAAAAGACTGAGAGAATTAATCAACGTTGTGAGGATTTAGAGTCTCAAGTTATTGCTATAACCAAACACAACTACACACAACATTTGCAAAAGTTAAACCAGGAAATTAATAGTCATAAATCATATCTCCAGAAGTTAGAGCAGAAAATTGGCTTTTTAGAAGATGTAGCATCCAGACAAGCTAAACAGTTATTTTTTCTCAAGATTAGCGGTGTTATTGCTTTAGTTAGTTTATGGCTTATCTTTGGCATGAATAATCAACCTGAACAGAGCAAAACCAAGCCTCATAGAAAAGCAGAATCTCTGGAATTTACTCAATCTTAATCTATGAATAAGTTATTTATAGATATTTAAATCATCATCAGCTAAAGAATTGGAACAAAGTGAGAAAATAAGATGAGAGCAATTGTTAACGGGAAACTGGTTGATTTACCAGAAGGTACAACTGTTGAACAGTTGAGAAAAAAGTTACCAGAAATTGGTCAGGATGATGTGATGGAAGAAGGTTTTAGTGGTACTCGTCCTCTGAAAAATAATGAAGCACTAAAAGAAGGTTCAAAGGTGTGGACTGTACCTAAAATCGTCAAAGGATAAGAGAATTTAATATTTGAGATTTTGGATTTAAAGAAGTGACTAGAGGCGTTTCAATACAACGTCTGTAGGAGAATTGGAATTGAATACTTGGAATTTTTAAGGAGAATTATGGCAGTTACAATCAGTCAAGAAAAAGCAGGATTTAAACCCAGTCAGCGAATAATAGAAGAACTAAAACTGTTAGAAAAAGTTGCCAGGAATGTAATTGTTGGTAGCAAGACGGTTGGTGATATCAAATATATTGCTGTTTTAATTAAGGGAATGCCTTTGTCTTCTAAAAAGTTTACAGTTTCAAATACAGATGTGTTGTTTTTGTTACCACCAGATTACCCACGACTTCCTCCCATTGGCTGTTATCTAAATTACCCATGGAATACGTTAGGAGAAGGAGATCATCATTTTACCCGACAAAGTTATTATGGAGCGCCATTTCTAAGTGAAGAAGGATGGTACTGGTACTGTGTGGGATTAGGAGGAGGATTTAACCACGATGTTTGGTTAAATTCTTGGAGACCTAGTAATAATCCTGAGAATGGTCATAATCTTGCGACTTTGTTTGTAACTGCTCGTCATGCGATTAATAGTGATGATTGATTTTGGGAAATAGGAAATAGGGGATTGGGAATAAAGCTGTCAATATGACCGCAGACATGATGAATTTACACATTTGGGATGCTTCCATTTAGTCAGTATTTAGAGAAGCTCCATCGCTAATAGCTAAAAACCATGAATCAACAATAAATCATGAAAAAATCTACTGCAATTTCTCTACATATACCACCAAAGATGTGGTCTGAATTTCGAGAATCTATGCTCAAGTCTCGGATGTTTAATGAAGAAGTAATTGGTTTTTTATTTTGTCAGCGACATCAAGTTTCAAAATCCAAAATTCGGTACATTCCCAAAACTTGGGTTGTTCCAGCTTCTGACTGCTACGAACATCAATCTACAAGTGGATTGGTATTAAAACAGCATTTTCATTCCTATTTGCTAGAAAATCATCTTCAGGTAGGTTTAGATGTAGTTCACATTCATACCCATACAGGTCAAGGTATACCTGATTTTTCTCATACTGATGACCGCTATGAGTCGGAATATGCGCGGTTTATTTCATCGAATTTTCCTAAAAAACCTTATTTAATTTCCGGTGTGTTCGACGAGAATTTACAATCTGGTCAATTTCGGATTTGGGATAGAAAAGGACAGAAATTTGAGTATCTTAATTTCTGCAATTCGTTGTTTGAAGTATCTAAATTTGAAGACGTAATAAATCATGATGATTCCATATTTGCTCGACAAAAAATATTTGGCAAAGGAAATCAAAAAGCGCTTAATCAACTCAAAGTATTACTTATTGGTTGTGGTGGGATTGGTTCAATTTTCGCTGAATTATTAGGACGTTTGGGTGTGAAGAATTGGGTATTAGTCGATCCCGATCGCTTGGAGACAACAAATCTCAATCGGATGCCTAGTGCTACACAAGAAATGGTAGAACAACAATGGCATAAAGTCCATTATGTCAAGCATCTGATTAAAAAAATATATTCTGAGGGTTCCAGCGTCAAAACAATTGTAACTACAGTCGAAAGTGAATTAGCGAAGCAAGAAATAGCAACTTGTGACTTGATTGTGGTGGCAACTGATAATCATTTTTCTCGCAAAACTGCTCAGGAATTAGCGTTGCAATATATGCGTCCTTTGGTTTGTTTGGGAACTCATATAGACATGAAATCAGATAATACACCGCGAATGTATTGCAGAGTTACGGTTCCCCCCTTGGGTGGTGCTTGGTGTTTGATGTGCGGTAATATTATTAACTTACAACGTGCTGCTTTAGAATCTGCACCGTTGGCAATTAATCAAATAGCTGCTAATGCAGGTTATTTAGAAGGTGTGAATGACCCGGCGGTATTTTGGTTAAATAGTATCTGTGCAAGTACAGGTGTTGGTGTAATTCACGGGATGGTGAGTGGTTTTTTGAATGTAGATTCTGGGATTGATTGGATTTATGAGTTTCCTGATGGTAATTGGCGAAAGACTAATACCGAGTATTTGCAGAATGATGATTGTTACTTTTGTGGGATGGGGAGTTTAGAGGAAGTTGTGGAAGATTCAGATTTTGAGGATTCTGATTTTGAAGATTCGGATTTTTTGGGTTCTGATGTTGAAGATTCAGATTTTGACAATTCAGATTTTTTTGTCTGGTAAATGGAATAGCCAGGGATTGCAAGTCCCTGTCTCATAGCTAAAGCCCTCTTTAAGAGGACTCAGTTCGGCGTAAATAATCCAACCAGACCCTCCTCTCGTGGAGTAAGTAGTCTCTCCACGTCTACAAAATAGAGGAAAAGCCTATTTCCACTGCTGTGATACATTACAGCATTAAATTCATCTGAAGTGTCCATAATTAACTCTTCAAATATACAGGAGAAAGTTATGAAATTTAGAAATGCTAAAGGCAATCTCGCTGTTATTACAATCATGATGTTGTTTTGTTTAAGTGTGTTTAGTTATGGAATATATGCAAGTTATTATGGATTGCAATTATTTCAGCAAGGTGCTTTCAATTTTATTATTGGTCTATTCTTTTTAGGTTGCGTTGGGGTACCGAGTATTTACTGGGTAGTGTCAACAATTTATAGGTATTTTGCGGCTGTACCTTCTTATATTAACCAAAGACAAATACGAGTAATTAATCCTCATTTATTACATGAAAAAGGGTTATATTTTGAGACTGAGAAATCCTTATGTGCGGCAGTCAAAGAGTTAGCAAAAGCCGAAGGATTACCCACAACTCCAGTGGTGGGAATCGAATTATGCGATGATAATCCGAATGCCTATGCGGTTGGTGCAACTCGCTCTTATGCGATGGTGGTTGCAACTACTGGTTTGATTAATCAACTAAATCAACGAGAAGTTGCTGCTGTGATGGCACATGAATTAGGGCATATTGCCAACTTAGATACGATGGCAAAAACTTTGCTTTCAGCGGCTTTGGATGGTGTGATGTTGATACTTTTTACGCCAATGATGATGATTGTATGGTATTTTGGCAGATTTGCGGCTTTGTTAATGCTAGCTGCTGGTTTAATTTATGGATTGTTAGGTAATTGGCAACATGCAACAGGCTTTTTTGTAGGTGTGTTGGTTTGGATTATTTTAATGATGTTGCCGATGATTACAAAATTTCTCGTCACATTATTAACTTTTTGGCATAGTCGTTGGCGAGAATATCATGCTGATGCGGTTGCTGCGAGATTAACAAGTGTTGATGATATGGTATCAGCATTGGCAACTCTTGACCGTTTACCTTTTCAACCACCGAAGAAGAATAGAGAGCAAATGTCTACTTTATGGATTCGGGTAGCGATGAATGAAGAAACAGGGACTTTTCACTGGTTGAAACATACACATCCACCAATTCATAAAAGAATTGAAGCTTTGAGACGTGGATTATATTTGAGATGA

Protein sequences of DBSCAN-SWA_3

>NC_019751|2803324:2918529|2820648_2821677_-|WP_015198017.1|DBSCAN-SWA
MKATVYYAPGDVRVETVPDSTIQEPTDAVVRITHACICGSDLWFYRGSDDWKPGWRTGHEWMGIVETVGSDVRNLKKGDRVLAPFAFSDGSCEFCGKSLQTSCIQGGFWGGTNDGGQAEAVRAPFADATLVKIPREVENDDALLTAILPLTDVMATGHHAAISAGVRAGSTVAVVGDGAVGLCGVLAAKRLGAARIILLGKHEKRIEIARRFGATDVVKSRDQQAIDEVQEMTKGGAEAVLECVGTESSFSTAIEITRPGDTIGYVGVPHGSVKLAGMFLSNITLRGGVAPARAYIPELLADVLAGKIDPSPVLDLTVDLDGVPGGYAAMDERKAIKVMVRL
>NC_019751|2803324:2918529|2803324_2804860_+|WP_015198003.1|transposase|DBSCAN-SWA
MNENCLPYGIEIPDSDWEETPASVKQLVEKMEQYIKESDKRFASLEAKYQELLEKINRTSKNSSSPPSSDPLNSEKQKQKKKSDKKRGGQPGHKGHSRHLYEVSECDSVLEHQPEKCKCCGEKLVGVDSNPVRHQVVEIPPINPIIVEHRLHQLECQHCGTLTRATLPADVPIRGYGVRVVALVAVLSGLYRQSTRMVQSAMQDIFGVRMCLGTVNKLRLEASDAIAGAVLEAKTYVQNSPVVGADETSFSQGNVDGCNDKNKKAWLWVAVTPLVTFFQVTLSRCTDTAKNLLGENFGGILNSDRYASYNWVDLEQRQLCWAHLKREFIKISERSGVSSSIGNALVEQQEKLFELWHRVRDGTLSRCEFQLLVPQIRNLIKSNLQEAADYKIGSQEKTPLAKTVRTCRQLLKVEQALWLFVEVEGVEPTNNAAERAIRPAVIWRRTSFGSQTKAGSNFVARMLTVVTTLKSQRRNILDFMTQAVSAQRLSHNSPSLLPQNSVNSISVKNTA
>NC_019751|2803324:2918529|2804948_2805461_-|WP_051036650.1|DBSCAN-SWA
MKGKWDFSQVLDSPANFIALRAWFSGRCDKAIIEDWLFQAGNYKQKQVYEELVHKTRMTYRDELSLSNPFKWQHYTNNSIVFNFKSEAYAQCWSTLRDINTLACASRLKGLIILFDEFEDILSNITNIAHQKAAFQNIFHFFAGNQFNGMSFFAVTPEFVDKCKKVIDHG
>NC_019751|2803324:2918529|2899171_2899747_-|WP_015198081.1|DBSCAN-SWA
MAVEHINRKGQKYYLHQGTTKTGKPKYFFSQKSEGTLVQTIPDGFEVYENPNAQVFLQRIQPKIITLDEIATVEKGIQKFSHLHYCKIDVKKDTIYVYTPNQNVNNLSKLYSSFSTANPVDIETTIARSISYSSMLRFILYNEQKRIFTAQRFCFLGSIDDWIGIGYPDTLPTLVEKYMQHLEKDSFYELH
>NC_019751|2803324:2918529|2830352_2830550_+|WP_015198027.1|DBSCAN-SWA
MPIIPNSEKAPNSHQYWYNRGLALHYLGRYEEAIESYDLTFPVKSLLQAANPHKGRAILTKLLSG
>NC_019751|2803324:2918529|2888011_2889468_-|WP_085953324.1|transposase|DBSCAN-SWA
MYRKIENPPTPIEKFELPFEGQLAEDNRWVIMANFIPWSEFEDEYAQQFRIEMGAPAKSFRTAIRALIIKERLGLSDRETVEQIRENPYLQYFIGLNKYSNEAPFEASMLVHFRQRIDIELVNRMNQSMVKNSREEESEEANEKKLLFLEEKKKLNEERNQGKLKLDATCIPADIKYPTDLGLLNEAREQTEEIIDILYEELDDNENKKPRTYRNTARKEYLDVAKKRRPSKKQRRKAVKKQLGYLKRNLAHIDRLIAVGAKLEWLSSQKYKILLVVNQVYRQQLFMYENSLSRVDDRIVSLTQPHVRPIVRGKAGSSVEFGAKLSASCYEEYVFLDRISWDNFNESDDLKEQVEAFKAATGYYPESVHVDQIYRNKENRKWCKERGIRISGPALGRPAKNISTETKKQAQLDERDRNCIEGKFGEAKRRYSLARLMTKLSNTSETAIAITFLVMNLGALLRRIIMTFFCIYFRKYCIYPVFRFG
>NC_019751|2803324:2918529|2902500_2904210_-|WP_015198085.1|DBSCAN-SWA
METNYTFKFNSSTASEALKAGLYHPINFYEARLDLFNLSVMADYDQLICLPTLTAIDKYWYQIETARKVLRQLGGRALLADEVGLGKTIEAGLIIAEYLARGMVQSLLVLTPASLVSQWQSELSDKFNIATITTDNRDPQQPIEEFWTDNPRIVASLNTAKSAKHYPHVTNRTWDLVIVDEAHHLKNRSTLNWKLVNALNKRFILMLTATPVQNSLVELFNLLTLLKPGLLQTEAAFKKEYVDSKNGRVPKNPEKLRSLMREVMVRNTRALVDVKLPKRFATTITVTPAAGEEKLYQDLSEYLRVAADKLDRLSRTNLLMRAGSSPGALADSLKQLSKRLPDEELKSLAKRASQVKQVEKSKALVEMLSKSSQKTLVFTTHKATSTYLAQTLQAAHIPFAEFTGGMSLKQKDEAIAAFRDDVSVLLASETGGEGRNIQFANAIVNYDLPWNPMKIEQRIGRIHRIGQTQDVFIFNFCLKGSIEEYILRILHDKINMFELVVGEIETILGNVDDEFDFSEIVMDIWLKHQVKPELDTAFEQLADNLLNAKNQYQQVQELDEQIFGEDFEA
>NC_019751|2803324:2918529|2858703_2859069_+|WP_015198048.1|DBSCAN-SWA
MLTTEFEFTLPRGLMDEERVIHRHGVMRLATAKDEIIVQKDRRTQDSPAYGTLVMFSQVILKLGNLSQITPEQLENLFSFDLSYLREFYDRINQQGNAQIPVICPSCNHKFRQELMLSGEL
>NC_019751|2803324:2918529|2833248_2835486_-|WP_015198029.1|DBSCAN-SWA
MLKSKEKILTKIDTNQLEFKLGGVSFDVTVINNSDGFATFQVELLADIAKGNISDDWYRISPDVCTKKPPGDSTTFTIRIIDIPKRGFAGVMTLTVRVFSLELPPSEESRQVIRLLIPGDGIPAPQIELLSQEFNRYPGEVFQIPISIESLSQKASKITLRLNGLDLSWFPKGRERDLRLPGGSKIREVFECQIPNDFILAESKHYDFTIEASQLDTTAVRVDGVVKVLPRGYVDFNCKKTIPSLADVELPKKNRWLFWKQYLAIQEFSLEFDNQSNLCQETTIKVIDLEALDKKNLKFPFWFKFGDTKKKQNQENILETEAKEKQNSSLTWEIFPEQANLSLNKPTNFNFKVQHKRPWFGWTKLKYIQAQAITSDDRIEVRNDTQTLELAVPPMLPLWLQLGGLLLGFLIGSTIVNRSFWLEQQHSQPVNSLRLSGLGREAVSGSNDQTIRRWLVQDNNLRPLDVLLRADKAVRVVRYRPVNNDQIAIGFENGEIQLVNLLSGEVSLPLSSNNQKDDRVFDLVFTKDSRSLFSGHGSGMVWQWNIQDGIPLNQRIQRSIQVGFAVNTLALVGPDENHVAIAGRFNQLTLWNLKNNQLQPMKNYGVDSQENYINSIATVDKKPYMIATADNQGSIKTWNLRSCLTGKDNCELIEEWVLDKQAIRSVAFSSDGCYLASAGDNGQAILWSLNSKGERRGDGQVIYQSSKPLKSIDLNRDRNQLLITTAGDDPQVRLHRVTKAISSCQ
>NC_019751|2803324:2918529|2914866_2915064_+|WP_015198092.1|DBSCAN-SWA
MRAIVNGKLVDLPEGTTVEQLRKKLPEIGQDDVMEEGFSGTRPLKNNEALKEGSKVWTVPKIVKG
>NC_019751|2803324:2918529|2909155_2909956_-|WP_015198090.1|DBSCAN-SWA
MLVKIFISGLIGAASSVAMNYGIASVPCGLVSPGADKVCFIRAFTNSLDSWKFGFILGGIFGLVSGVDYRRMKSRIQPIHLSLASVSCLGIYCLLGSQSFGFNTNSHQTDIGVSSKYSPRMQAFLATIRWAETGNSGTESYRKLVFNGNFNDFSTHPLIKQCAPINGNRICSTAAGAYQMLDKSWWDLQPKLKLADFSPVSQDRMAVEYIRRNRAIADVESGNFDKAACKVGKIWASFPCNSYNQNPKSMEKLNNYYRQQLLTVGG
>NC_019751|2803324:2918529|2874136_2874481_+|WP_144051038.1|DBSCAN-SWA
MDLTSKSKIIQAVWHLDSLREEETGIICQDNYRARGRKKTEILQPMLEADIKSLVDSQAQADPKFQSNFYYARISARAVREKLISFKGYEDSLLPSRQTIGDILNRMGYILKKH
>NC_019751|2803324:2918529|2895790_2896126_+|WP_015198077.1|DBSCAN-SWA
MAKNLNEIMQNLPRDRVQKIEARAAELIAEYMTLQDVRKARELTQERMGELLGIRQDSISKLEKRTDLLLSTLRGYLNAMGGELELVVKFSDRPPVIITGLAELDDEDYET
>NC_019751|2803324:2918529|2859958_2861137_+|WP_015198051.1|DBSCAN-SWA
MAESNNLPVTNNYSSEESLSTEPLGIKNPLLPSQTLGEKGINPQFLIPLGVKSISVLDTNLVSPKYIEDDFSSSLFEDSPFFSEYTNQVQVDTDRQINPSLAISLQVKGQGIQAQSDINYSSEKISSSENFTQSTENQVQPSLINPDVTNSPEIQLKQDLTEDFKRSHFNQTAENQVQSSSSNPDVADSPEIQLKQDLTEDFKRSHFTQTSENQVQASSINTDVTTSPEIQLQQDVKESFVRSHFPQTPENQVQPSSINPDVADSPEIQLKQDLTEDFKRSHFPQTAENQVQPFSINPDVADSPEIQLKQDFTGNVVRSHFTQTAENQVQSSLINQDITDSPEIQLKQDVTESFMRSHFTQTAENQVQPSSINPDVTDFSRNSVKAGFDRRF
>NC_019751|2803324:2918529|2819027_2820599_-|WP_015198016.1|DBSCAN-SWA
MGNELNAYLLGGGIGSMAAAAFMIRDDGFCGENIFILEVKSVVGGSMDGAGNPTDGYSLRGGRMLTTDNYECTWDLFKSIPSLNFPGKSVFDETMEFNQQHKSNSMARLVDRRRGKVPVSSMGFSMANRQELLKLTQAGEAELGASCITDWLSPEFFETEFWYMWVTTFAFQPWHSAVEFKRYLHRFMLEFTRIETLGGVKRTIYNQYDSLILPLKSWLATQNVHFVLDCQVMDLERTTAKGKLVVTGIHYQQSGESKTISVKDGDLVFLQNGSMTDASSLGSMTSAPKKLTKQDCTSWNLWEKLAAENPDFGNPAAFNSSIAESCWESFTVTLKNPKFFDKILEFSGNQAGTGGLITFKDSNWLMSIVLAYQPHFINQPADVQVFWGYALLPDRVGNFVPKPMDECNGEEILRELCGHLRFDLDIVESANCIPCRMPYITSMFMPRLRSDRPLPIPRSSKNLALISQFVEIPDDVVFTVEYSVRAAQMAVYEFLSIDRPIPPISHHDKSLHVQFEALVKAFK
>NC_019751|2803324:2918529|2895424_2895778_+|WP_015198076.1|DBSCAN-SWA
MAWEVLFHEEFEPEFYELPQEAQDELLAYAKLLECESPHLKRPHADTLNSSSYDNVKELRFKAAGGVWRVAFAFDLKRQGILLVAGDKAGTSQKRFYKQLIAKADKRFGEHLSRLQE
>NC_019751|2803324:2918529|2843870_2844272_-|WP_015198036.1|DBSCAN-SWA
MLDTNKNHLGQGLAFPLNVTMQGNMQISPKNQNIEESIGIILRTHLGERVYRPDFGSRLGELAFAPMNTQTLLLARLYTQEALEKWEPRIVVDAVRAEPDPVRGRLDVIIEYHPRNSHEQRSLVFPFYLMPGS
>NC_019751|2803324:2918529|2844649_2847112_+|WP_015198037.1|DBSCAN-SWA
MAKQEQLQKKPSTTVSEPQNSSEFLQTRPFATSEQTTQPNLQAKSDTNPAGTARQNKDGRQEHRTSDFGHSFGNLAVSPSTTSVQPKLTIGQPGDKYEQEADSVAADVVQRINQPQAASSKQEETVQRQEVPEEEELQMKPLADSIQRQEVPQEEELQMKPLADSIQRQEVPEEEELQMKPLADSIQRQEIPEEEEIQTKSLLQRKTNNENQTAPDSIETSINQARGSGQSLGDVQGSMEQAFGANFSDVRVHTDAKADQLNQTIQARAFTTGQDIFFRDGEYNPTSRNGQELLAHELTHVVQQQPQMVQMDKDAVEPEKGVNPPPEKKDISWIYDTLKQLKSWNAVKDKFISDEPTMRQFVEFRKTYVDSKINELRQKYPTLIAKSVGSKDLSSDYDITISTPGTGEDVEAVDEFNNAIKAEFGVQPGTLFDTNLYAKDFLKVEGNIKPDVEQQQQEDSDLAQPENQNLGKLTDLDQDVAALVKQRRFMNQGEWDKYTESVVSGIADKKQKQAVLKQYEEADAIFQISAHQLLEETKKDEKVHQEKGQLGKEENDELSKIKDGKVREQVEKQLLGIEELHLITHENPDLVLEKSNQLYIDKMRQVRVLQCLIQNPEEENVDAMKAEVKKLLGEACFFAAEAYHSEGAVKHVVAGLQGDNAQEALKKLTPENILQSYNEQLGDFLKDIVHYTQEKAHHGKVFYRSSKYLYRLFDAIKEIKKRPEFADIQLTIGDENLFAAIIESGLLAIRKGNLKFASEEETNLASVDIVKQSFGVDTSEGLKQKVLQMSVEFNQKVRNKLSFLTDKNAETQYFKNVQRR
>NC_019751|2803324:2918529|2907135_2909151_-|WP_015198089.1|DBSCAN-SWA
MSNYDNAEITCAVNALKLQGLSNQEILTEAEQVFDLSQQQYVVDILQESDFGSKIIRPIKSYDHNYLFEIIYQAVISGTSVEQIIDACSEELNLEDLAFSKLALEYILTNRYISKYERDAFIIELYQQYQEIKSYQDLIKIAESTKNIYLKQLVYKTAELVAKKNGEIPSLSLEKGIAQNNAIANTAQNTTLVQESFNSQVGNTLVETLNDFGITCSYIDTKTGPTFKRIKIKLGKGVSFKKVQGLGSDLVQQLGEQLGFDNPPMISVIPGAVVFDIPRCDRQIANFSDYVDLQSEIDINRIVIPAGVDVDGKYIEISLCDSNVYHTLGGGMTGGGKSQFEKAMVLYLALRYPPSLVKLALSDVKLVSLTCFNGLPHLIAPVAEDAASTLQIFNYLVAEEELRYQEFKKVGVENINEYNQMFCDRPMPRIISVTDECFDLLSDSTYKDQIEMALMKLLAKAGAAGINIFLFTQRPDKDVIKPLIRSNCSGKVAFMVSRPEDSGIILGNPDDDRAASLLGGGDMLYKSPKGVMRLQGLYLGTKAAFKGYLDQAMSAGNNSPCWDSKLNFSSFNIELKGETSSNNQTLRTKLNKLTTDSLVNNNHSEEFSFNITIDDLTKSQIYSLHSRGYELHQIVQEVFNLSRADGRKYKRIRDIIAEFIANLEEEDNNDT
>NC_019751|2803324:2918529|2850064_2852098_-|WP_144051114.1|DBSCAN-SWA
MQHLNRLRQVLERARGKGEEEKGEKHSYSPSSPSSLPALEKICQNLGLSAFERDILLLCAGVELDASFASLCAEIQGDSQRNYPTFSLALAILEQAYWGALTPDAPLRKWRLMEIGAGNALTTSPLRIDEQILHYLTGIHHLDSRLAGIGTPVKTREKLVPSHWQIAMQMANTWYLAAQSEEVLPILQLCGKDVASQRAIASATCGQINFIPYSIGVELLPHETGNLNLVKSLWEREFALNNTTLLLEWDNWDNSDRKQEMAIAQFIESIQAPVIIISQERRPQKHRPIIAFDVDSPTTEEQRLLWHQTLREFAPSLGEEVENIVSHFNLSAPAIRGVCLKAKSLEETKGETGNGKLQEEHITSSPPSPPSPPSPSSPSSPSSPPSPSSPPSPSSLWDICRTQARPRLDELAQRMESSADWDDLVLPEIEKQVLRDAADQLKQRTKVYEEWGFGGKSKRGLGISALFAGASGTGKTMAAEVLAREMRLDLYRIDLSAVVSKYIGETEKNLGRVFDAAEVGGVILLFDEADAIFGKRSEVKDSRDRHANMEVAYLLQRMEAYPGLSILTTNLKNAIDQAFLRRIRFIVQFPFPDANQRAEIWRRVFPKNTPTEGLDEWKLAKLNVAGGNIRNIALNAAFIAAQAGQVVQMQYILQAAKSEYIKMERPLTDVEVKGWIS
>NC_019751|2803324:2918529|2857610_2858099_+|WP_015198046.1|tail|DBSCAN-SWA
MSDNKFEVLTSSKFYLEIQLDGSDNRIDAYFMECQGFERTSDVIDFCQVTPQKWGKNSSAVGRLVRTKMPGNSKTGNLILRRGMTTSMIFWAWFSAVEQGQWSQKRKNGDLVLYNQASDEQARFRFFGAWPVKYKISDVKAGSAEFEIEEVELAIDEFKRIK
>NC_019751|2803324:2918529|2858360_2858678_+|WP_015198047.1|DBSCAN-SWA
MQTEFEFTLPKGYLDEDGNTHCKGVMRLSRAIDEIVPLRDPRVKSNPAYATVIILSRVITTLGALDEVTPVVIEGLFACDLSYLQKFYRQINELESDIAELAVPV
>NC_019751|2803324:2918529|2817991_2818993_-|WP_015198015.1|DBSCAN-SWA
MTDVISREVVLVSYPNGLPNADNFAIAQTKLEPLQDGQVLVRNLYMSVDPYMRGRMSDRKSYVPPFELGKPLNGGAVGEVLESRAKEFNHGDIVTSSFGWREYFIAAPKELHLVSQEVQPLSVYLGALGMTGMTAWVGLNLVNVKADDVIFISGAAGAVGSVAGQLAKLRGCRTIGSAGSMEKVKFLREECGFDIAFDYKAAPILEQLNREVPDGIDVYFDNVGGEMLEAALSVLKVHGRIIACGGISGYNQEKQPGPSNLFNMITKRLTMKGLIVSDWLAHQKEFEQEVGKYFRDGKLKNKETVVVGIDQAVSAFIGLFEGKNVGKMVVKLD
>NC_019751|2803324:2918529|2807351_2808608_-|WP_015198006.1|DBSCAN-SWA
MEGRIATQIVESLRKGIPPMRGVDKYSVGNEKLIEGIKKHHFNGITERGIIRFLSGSWGSGKTHFFRLLREVAFQNECLVSNVQLNADDAALNKFEKVFYSIVRSISTPEYFSENSFYETTPFGRVLQESLAYLANGKISNIFSYEEYVKARETLMLDRSIDIDFKKMIQKYWETFLPEAPDVALQEQNRAEILQWFSGEGSLATYRRKFEVNKIVNKDNAKIMLQSLAGFVRLSGYKGLVILFDEAEQAYSIMRKSSLRDAHNNLLSLINNIESLNGLFLIYATTPDFFTDPKHGIIIYGALQGRIGKPEQRKPRALDSVWNLDEVETNLSEYQAAAEKICSIYASAYLEASVELPSEAGINAFVKELFEIHPSLSGVRFWRVLVTTLIAHLDDYLEGEVRTTETIYGDVMDRLRED
>NC_019751|2803324:2918529|2909957_2910599_-|WP_041739464.1|DBSCAN-SWA
MRIKLEIDRTKASNEDETVDNQQLDRISNDANWHYAFASFFLTLAIALPQISSWVESQYLVKSLQNLIVTTNTTDFRDARIAFPTVKNAPVTSGFGWRIHPITGERRFHTGIDFGADLGTPIYAVDAGSVELAGEKGGYGNTVVVNHNAGKSTLYGHASKLYVREGQQVIKGQMVAAVGSTGMSTAPHLHFEVRVNGKPVNPRPYLQQYLAGR
>NC_019751|2803324:2918529|2835697_2837098_-|WP_015198030.1|DBSCAN-SWA
MPKLSLSKTLPIAFLVPLLTCVGLLGVTAVLTGQKIAGKFSQQSMEILSEQIKQRLNNFLDLPHIINQINTDAVEIGQLDLQKNKNMEILLWHQIQAFKEVNGIQFGSEFNGELYSVVREEKKGELSYNIADSSTNMDAVVFSTNDKGDRAKEISRISKYDARKREWYKIAIEARKAIWTPVFPKKTTKNTQLRLSAVQPVYERKNGKLLGVWSVDFFLNQISDFLVEITKNTSREIFIVEPNGKLIAASTKIQVFDDKGNQFSAKDFNQEPLIKATSEYIEKTIPGGFANIPGQKHFKFYSPDRELKLVKITKFFDDDKQYKGLNWLVVIVVPEKEFMQDVNRVRIFAIVMAFGVVVLSLFLGVLVTRWLAKPILGLSHAAEKITSEEFDLASLKITLEPITKRSDELGELADIFQKMAQEVYEREVDLKNKVNQLADRANKATLAKQSNVQELLARSQKARDKI
>NC_019751|2803324:2918529|2914410_2914794_+|WP_015198091.1|DBSCAN-SWA
MGTVNGKLINQKINHFDELTQKTERINQRCEDLESQVIAITKHNYTQHLQKLNQEINSHKSYLQKLEQKIGFLEDVASRQAKQLFFLKISGVIALVSLWLIFGMNNQPEQSKTKPHRKAESLEFTQS
>NC_019751|2803324:2918529|2805562_2806903_+|WP_015198005.1|transposase|DBSCAN-SWA
MFDILSLLQCFLPQINATTMKQLNQIILAMLAMSGRVTMLGISRWTGSGGSYRTMLRFFHTVIPWATLFWLFFRKHLFRANEVYLLAGDEVVVSKSGKKTYGLDRFFSSLVSKPISGLSFFTLSLVSVEQRHSFPIQIEQVIKNDIEKSSVSPRPEIKAKEKRGRGRPKGSKNKNKTEVILTSELLRIKKMINELVKLVANFIPLTYLVLDGHFGNNNALQMARQVNLHIISKLRHDSALYIPYQNPDPNHRSRRKYGDKLDWRNISDEYLRQSSIEEDIQTDSYQATLLHKEFAQSLNVVILVKTNLKTNARSHVILFSSDLKLSSEKIIDYYKLRFQIEFNFRDAKQFWGLEDFMNIGQTAVTNAANLAFFMVNLSHHLLADFRILNPDSGIIDLKAHYRGFRYVHEILKMLPEIPEPILLTRIFAKLTSLGRIHHVSTGVESS
>NC_019751|2803324:2918529|2876881_2877037_-|WP_015198060.1|DBSCAN-SWA
MSQIIVKIATLKNEFAAIEEIRKRVFQQEQKVCAELDFDGLDETLRSPRPT
>NC_019751|2803324:2918529|2825970_2827872_-|WP_015198023.1|DBSCAN-SWA
MPSLLRLLTLSSIIVIFPNTTALAFNDTQEYWGNNCIRELNSRKLITGYPDNTFRPNLTVTRAEAAVLMLNAFPDTPNKRNSTPFRDVPPTHWANKAISTAYQKGFFSGYPGRIFQPNQAIPRAQIIGVITGAKNYNSISNPAQTLQKYFLDAAEIPGYAQNAIASAAINSIIVNYPNIKQLKPNQSATRGEVAALMCRALNIYTIPPQYIAGVEVKPQQVKPLPGKLDTIPTFNSNSPELVESDGILLSTFPPSGKKTPAAHLNYPFQGRFDIFSHHIVRAETAARNRTVYQGIIVHNPGNQPVTLEILNGASYLTQQAPFIPLPDIQNNSQNTVYSGPGSRTMGDVLQGMRQNIFPEKIVIEPGKSQILANLPIPVLAPSSNGRTTMMRLQSDGVIYIANLAMTANRLPTLPEWQNLLNNGNLAEKRDAIPTPLEPPREPTVFGRVAGVSQGAKWEGVITDNSEATKLTIPESGTAISYPLGTVHLVTLATKQIQSAKMLARYPDTAYFAHSNYGVEYDLTLPLHNPTNQTKTVNILIQTPLKDEGGTDRLLFLNPQVEQIFFRGTVKVSYEDDLGKMQVKYLHVVQRRGQQGKALVTLQLAAGATKKVEVDFIYPPDSTPPQVLTVETAR
>NC_019751|2803324:2918529|2901328_2902369_-|WP_015198084.1|DBSCAN-SWA
MISDPIIATLEKIISLHDSIAEPAGEHILNALLTKNIASLLSLSEEVTFATIADVPQSVFVTYHSEVLNKLSELLATKGLISTLGIKFDGYLKTTGFEKSIAERFVVQNGLMRFIDAKPEITRYILCNVAYTANAEEKRIGLVSFMINELTGVTPVEIGDALFWESDRIDVEHQESLLSIPFNELLMLIEHQSKILIGKSLENWQAKLIRARARDEERLKDYYNTISSEIRHKIELKHLSDDEKDKELARIEATNRELERKLLDIQERYAMSVEASLHSAMIINLPTVHIQCELQRKKARRTVTVVWNPFSKIIEPLRCELSGEPVYDFYLDDVEAKIISSTVWRK
>NC_019751|2803324:2918529|2881951_2882407_-|WP_015198065.1|DBSCAN-SWA
MSSLAQIEAFLPVSSTITTSGQPTTEQFADIASAGYNLIINLATPASSNWNPEESAIVENLGMEYIGIPIDWENPTLSDFDELATKLDENPERKIWVHCAKNMRVSAMMYLYHRLRKGYTEISARRYLEQIWQPNQIWQNFIDATIELYEE
>NC_019751|2803324:2918529|2885133_2885481_-|WP_144051115.1|DBSCAN-SWA
MGELKIVRNREDLASLNGKKVKLVGYYTSQSSKPTVTGNPDFQGVYIKSQIVLEDGTVVHIFPSWNKQSLRSPLEMQKYKGKIVQGIGVVEFEVASSINSQTRESFINLEEFKDN
>NC_019751|2803324:2918529|2883543_2884158_+|WP_015198068.1|DBSCAN-SWA
MLTQDFTQVTLILRSLIDLPDDEAIKAIKLFQTSLLKRGEFFVRAGEMPKTIGIIMSGILRLYYVDSDGNEYSKSFCTENSFVAAYSALLLQQPSRLFIQALEDTKLMIADYAVFRELSTMHPCWQSLNSKIAEFLFIKKEKRESSLLLDDATTRYLNFQAEYPGLETRIKQHHIASYLGITPVTLSRIRAQLRYSTGVATRSR
>NC_019751|2803324:2918529|2857033_2857507_+|WP_015198045.1|tail|DBSCAN-SWA
MAKGELLACSKFYVQFDGLEDLIVKKVSGVSIELQTAGDQNPFGVTKGGKAQIQATVTGVQNSAVTVEYVGTVNDNRLFKWYEESHSQPTTGGGSTNKGALKTGSIVLYNQGGDEAARWDMTGVMPKAYKTTKMEAGSTELFIEIVEYAFHSIRRTK
>NC_019751|2803324:2918529|2854595_2856302_+|WP_015198043.1|tail|DBSCAN-SWA
MALDYFAPGVYVEEVDKGSRPIEGVSMSVAGFVGFSEDVRGDAELFKPMMVTNWSQYLEYFGKPGSDGFTDFSAYLPFAVKGWFDNGGGRCWVVSIGTKLPGSSAPTVEETATKLLTGNGKPSLMFNLKPAEGDTPALMPAGDRLIVSVIDSEPKPLPEDAPEGTDAPLNTGEFFSVVVRSGDRILERYDHLTMNPKVETAVAEYAVTILKASEYVSIADISQTGQALSRRPANGSYEIAPPPYVAREEHMARDMQGARTDKTGLQGIFEVDEVSMVACPDLMRVYQDGLMNIDQVHGIMEMMLSMCENSFPGPAFRMAVLDAPPIKPGKNENRAVPAEQQKPQDVYNWLRDFNRRSMFGALYYPWIKVANPRNGGKPILVPPSGHMMGLWCRTDQTRGIFKAPANDTPRGVLGLAYETNMREQELLNPVGINCIRNFVNYNRGFKVWGARTLVEPDNIQWRYISVRRLISYIEKSIEIGTQWVVFEPNDMDLWERVKRTVSNFLEGLWRQGALFGGSPAEAFYVKCDGELNTHETMMMGRLYVEIGVCPVRPAEFVIFRISQWAPGE
>NC_019751|2803324:2918529|2870153_2871908_-|WP_015198058.1|DBSCAN-SWA
MKITSIHNLQKLANIVGIFLIHLAVNQTQASAFISNTPTPYLISQKGLEDDLKDPNYWSNLCNLQMQSKKYEEALTACEQAITLRPKNPILWADHSGVLLKMKKYPEAIASAERALKFDKKTSLALTYQCMAFSELGRNEEGLDNCNQALKVDGNWGKQSPKLAWLHRGVILTNLGQLDQAAIAYDRTLLLEPKDSLALAYRCELMNKIGQPERAITNCNDALAGNGDWGEKSQTFAYSNRAIAYRQQDQLSKAIADYDRLLAVDPNDAIAWTAQGLILEQLSRFTEALTSFDRAVAINPKYSLGHVRRCTMLNRNKMYEPAQAACDEAIKGDGQWGEIGAAQAWSEMAHALSGQQQYEKAIAAANRAVGIKPDYAEAWSNRSVALWQLQQYPEALASIQKAIELKPNYAQAYFNQGTILATQKQYKTALQSYKKALILDPKNPEGWANTSVVLWHLKQYQSALTAADHAIAINRNSFEAWYNRGLVLTSLSRHKDALKSYNSAIKINPKSADAFTGRGIILSKLKYYPQAIAALQEALKLNPQQVVAKANLKMVMKEQASQIREQGKREKGKGGRGNTISRKS
>NC_019751|2803324:2918529|2875785_2876799_+|WP_015195997.1|transposase|DBSCAN-SWA
MRFTKLNYCQYLLSSQINYTLTNLADHLEQISHDKINRYLKNEKLTPRILWDNVKDLIEINDNAYLVFDDTVIDKRYATEIEPSRRQYSGNEHGVIQGIGLVNCVYVNHEIGKFWVVDYRIYDPDRDGKTKIDHVMEMLQNLVYHKALPFKAVLMDTWYATNKLMLYIDGLGKYYYCPLKRNRLVDDTAGEEEYQRIELLSWDEEELKSGKIVKIKKFPQAKKVKLFRVTVSTDKTDFIATNDLSQDSTDVVQKVCKVRWKVEEFHRELKQLTGLESCQCRKGRIQRNHIACAILVWLRLKDLAYKSGQTIYKIKHGLLSNYLVQQLKRPNIPMFSF
>NC_019751|2803324:2918529|2866946_2867342_+|WP_015198055.1|DBSCAN-SWA
MPQQVVMGAALQCVPFGVAPSSLIVIPKGPPVLASGMLAATIMDFAPIANIPPFGMCNSLANPMVAAATAAAFGVLTPMPCLPVILGPWKPGAIKTQINKMPALPSTAICNCAWGGVIKIAFPGQIKVSVN
>NC_019751|2803324:2918529|2843430_2843778_-|WP_041740468.1|DBSCAN-SWA
MEKNKIESFEDLRVWQQGIELVKEIYLLTKEGEISKDFALKDQLRRASVSIPTNIAEGFERYSRKEYVNFLNIAKGSAGECRSLVRVALEVGYLDDRTYTQLYSQAIDLSRMLSN
>NC_019751|2803324:2918529|2864802_2866764_+|WP_015198054.1|DBSCAN-SWA
MTATYTATPILKIDGKDASANLLDDILKISVEESLHLPGMFTLMIRNDYYGSRSGENPWMHDNTFAIGKSIEIGFVSSTTEDSSFSSPEKSTLIKGEITAIEAQFNPESQAPIIVRGYDISHRLHRGRYNRSFQNMTDTDIVKKVIGEVGIAAGKIDSTGGPYGFGDPVGYTFQENQTNMEFLRQKAARNGFELFVQDGKLHFRKPVAGDSLSLKWLKDITHFHVRVSSAEQVSAVEVRGWDYQKKEAIVSNKTSQNSQVLTSTQQGKGEASISEFNKNPTMIVVDQPIFSQKESDAIAQSIFNELSGEFVQADAKAEGNPEIRPGKVVKLQDMGKYSGKYYVTETRHLFEARVYTTEFNVRGLREDSLANFISPQARLQPGQTLMIGIVSNNKDPKKWGRVKVKFPTLTDKHESDWARVVSVGAGKNRGFDCLPEVNDEVLVGFEHGDIHRPFVIGGVWNGKDAPPANVDDSVVEGKVRLRTLKTRTGHTLQFVEEDKGDSKKGVYLNTVYGHKLHLNDSDKLIDIKTKDNYQVTLDDQNKKILIKTNKGYICELNDQSQKITLKASSQEIVLKASGQIEINAQQNITLKVGGNKIEISTTNIKLTAGSSSIDLSPAGATLKSSAMTQVEGSMTTIKGNGTVTVSAPMVSIG
>NC_019751|2803324:2918529|2828934_2829336_+|WP_015198025.1|DBSCAN-SWA
MSQIIVLDTHIWIWFINQEFERFPAHWREIIETAEIVGISPVSCYEVALAQQRLRLELPCVVDEWLREALEPSGVTLFPITAEISCKAVSLSAVHKDPFDRLMIATTLVYQAKLASIDSLFSQYSELDGYLMN
>NC_019751|2803324:2918529|2814256_2814706_-|WP_015198012.1|DBSCAN-SWA
MIFQAKETTELRNPVSQIVNDFDTDLFLFSSSIDYAATDILINQVKKLEHRRKNISLILTTPGGDADAAFMLARFLKREYNDQLTFYIFGFCKSAGTIIALAAKNIVMSDFGELGPLDVQSVKEEDIRWESGLIPQQAFKALADQACVV
>NC_019751|2803324:2918529|2837184_2838273_-|WP_015198031.1|DBSCAN-SWA
MLQRFKLGLKFTFILGIVFIIGICLSGFLLSQTAQQKAEQQVANKAFILMETMNSVRDYTTNQIQPLLSDRWEIESKFIPETIPAYSARQVFENLRRSPNYKDFFYKEATLNPTNLRDKADNFEADIVQRFRQDLSLKEVSGFRKRSEDNLFYVARPLIISKDSCLRCHSSPNLAPKSQINTYGSEHGFGWKKNEVVAAQTVYITIEEIFESYQQQLVLSVGIFTVIFAILVILINVLLKHTVILPLRPIARIAQKISNADVGSEKTEASDLKKLDKVAKRSDELGQLAVLFRKMTNVVLEREESLQKLVQQLRNETDSAKKTALVTPKDGINTDLQSLLERSQQAREKVEFSKDKKNKEEN
>NC_019751|2803324:2918529|2912464_2913805_-|WP_015198005.1|transposase|DBSCAN-SWA
MFDILSLLQCFLPQINATTMKQLNQIILAMLAMSGRVTMLGISRWTGSGGSYRTMLRFFHTVIPWATLFWLFFRKHLFRANEVYLLAGDEVVVSKSGKKTYGLDRFFSSLVSKPISGLSFFTLSLVSVEQRHSFPIQIEQVIKNDIEKSSVSPRPEIKAKEKRGRGRPKGSKNKNKTEVILTSELLRIKKMINELVKLVANFIPLTYLVLDGHFGNNNALQMARQVNLHIISKLRHDSALYIPYQNPDPNHRSRRKYGDKLDWRNISDEYLRQSSIEEDIQTDSYQATLLHKEFAQSLNVVILVKTNLKTNARSHVILFSSDLKLSSEKIIDYYKLRFQIEFNFRDAKQFWGLEDFMNIGQTAVTNAANLAFFMVNLSHHLLADFRILNPDSGIIDLKAHYRGFRYVHEILKMLPEIPEPILLTRIFAKLTSLGRIHHVSTGVESS
>NC_019751|2803324:2918529|2899820_2901218_+|WP_015198082.1|DBSCAN-SWA
MVTTSINPYLDGNFAPVDKEITTDTLKVIGEIPPDLSGMFVRNGPNPQWTPIGQYHWFDGDGMLHGVRISNGKATYRNRYVQTKGWKIEREAGLAVWSGMLEPPQQNNPHGFYKNAANTALIWHAGQFLALWEGGAPHHIQIPNLDTIGEYTYNSQLKSAFTAHPKVDPVTGEMMFFGYSFAPPYLQYSVVSASGELLRTVPIDLPMGVIMHDFAITENYTIFMDLPLTLSPQRAQKGEPMMMFERDRSSRFGIVPRHGDNSNIRWFESPACYVFHTLNAYEEGDEVVLIGCRMSSTNVLSTKDTQSDPDGDIPRLHQWRFHLITGEVREQMLDDVPAEFPRVNENFLGRQTRYGYVGKIAQGSMPLFDGLIKYDHDNGKSQTHEFGQGRYGGEAVFVPFPNATSEDEGWLITFVYDSKEDTSELVIVNAQDINAEPVARVLIPQRVPYGFHGAWVSEEQLSASV
>NC_019751|2803324:2918529|2874459_2875221_+|WP_144051039.1|DBSCAN-SWA
MYFKKTLKTKPLKKIPETDQIFENVESAYQASDRNPKSLRISVDSKAKVKIGNLSRDGYSRTIEPKKADDHDSEWSAVLVPLGILDVLGNRLSIYFGKSAETTDFIVDCLEAWWQENKPSYTGLEELAIDIDNGSATRSNRTQFIKRIVQFSQKTQLKIRLIYYPPYHSKYNPIERCWAALENYWNGAILDSIDAAIKWASNMTWNSISPQVQLFEGNYEKGVSVSSQELEGFKPFWLQSEKLPKWDVTVFPC
>NC_019751|2803324:2918529|2896476_2896914_+|WP_015198079.1|DBSCAN-SWA
MSYFVVISGEGCCALPIARGIIVPIETAQDYVSSLAGLLTAIDGQPLFFWDDGKTGTSHEIVCEAESEAQMMLCGLEILQVCAFSKVLTDSDRLGCRIRVWWANNDPEAFLRVPCAEGALDAARISNRQVQNGNNIEFVMRPTMC
>NC_019751|2803324:2918529|2839993_2841043_-|WP_015198033.1|tail|DBSCAN-SWA
MTQSQSSQLIDVRLTPMQIPDAVPSKQGTQSGYGVGIKASTSAIASRQISLQLRPGEASEMVVQVKNLGNRPLQLELKVQGDFPANWCRIGMEGLDILPGTEMEAVLYFQISNDFFESPTALQPGESLKLNYQGHLYAYSMESDSGKNQVECIDFNLYVRPPSLYLDFLPGIYRDVDFIGRFLKIFEQSFEPCVHTVENISAYLNPLTAPTAFLPFLSYWVGWKHLPQISPEKERYLIKSAIEIFRWRGTRRGLRFFLHLVTQLPLDEDILNEEEKHISITESFSRGFVFGETLIGESSIVGGGCPFHFTIILRPNHQSEIDDFLVKNIIEQEKPAFCTYDLYIQSTER
>NC_019751|2803324:2918529|2917497_2918529_+|WP_015198095.1|protease|DBSCAN-SWA
MKFRNAKGNLAVITIMMLFCLSVFSYGIYASYYGLQLFQQGAFNFIIGLFFLGCVGVPSIYWVVSTIYRYFAAVPSYINQRQIRVINPHLLHEKGLYFETEKSLCAAVKELAKAEGLPTTPVVGIELCDDNPNAYAVGATRSYAMVVATTGLINQLNQREVAAVMAHELGHIANLDTMAKTLLSAALDGVMLILFTPMMMIVWYFGRFAALLMLAAGLIYGLLGNWQHATGFFVGVLVWIILMMLPMITKFLVTLLTFWHSRWREYHADAVAARLTSVDDMVSALATLDRLPFQPPKKNREQMSTLWIRVAMNEETGTFHWLKHTHPPIHKRIEALRRGLYLR
>NC_019751|2803324:2918529|2879324_2880713_+|WP_015198062.1|DBSCAN-SWA
MNSIKYFEYPSKEKLLGLPPQLGRWLFIPLGLIVLLCLGTVYSWSIFSGPFEAELQTKPGTILLPFMVLGITFTLVMPISGLYIYRFSPRIMTTVGGIIVGIGYLLASVAPNLPLLILSYGVIAGIGVGITYGVPLAVAARWFPDRKGLAVGLTVVGFGLSPLVTAPIALNLIKGNPQIGIPAFGIRSTFVILAIAFTIIISIIATVLKMPPPCWKPSGYASSEKLAVNNTDKNQSNILPMFQTQTFYGLWICYIVGTFVGLTAIATTAQVGKEIVGLQPEQLVWVVPLFAVFNGAGRPLFGWLNDRLKPKLTVITINLLILIASIVMLNTHNGQMSNFLVAFCLFWLCLGAWLAVAPAATLSFFGLENYPSNYGLIFTSFGIGGLSGIFTAGGIRGATGSFLPFFWVTATLACIAIILATFFLNPPRKTAIADFLFNRLISPISPGLLSLVEFFLMVGSRK
>NC_019751|2803324:2918529|2887081_2887705_+|WP_015198072.1|DBSCAN-SWA
MEPSRRASIGLEKRERTRRSLIEAAYRVFARKEADAVTIDDIIAEAAVARGTFYNYFQTREDVLKAVAASLSDDMNQKIWAQYAMIDDPAERMAIAIRQFLHQAIRDSTWGWVIVRIGLVAAPLSETIERGVMTDLQAGIRLKRFQVDNEKAAIDLILGTGLMAMRSILEGHTQPDYPEHITKLILKTLGIGDADAIAFKPLESLPS
>NC_019751|2803324:2918529|2852649_2853921_-|WP_015198042.1|DBSCAN-SWA
MSNYLAVATVTAILQRILQSAVQLDIDGVRVTTLQPRNIGNGTPETGINLFLYHVARNPALNNADATPFRSKGTPIKRQAAVDLYYMISFYGNDTELIPQRLLGSVIRTFNDYSTVSVEAIQEALADPSYRFLEDSNLANQLQQLLVVPLEINLDNLSKVWSVFFQAPYMLSLVYKVTVVTIDGDESLKRALPVSDRNLGGTVPFPNRPLVEQVVSATGKLEPILASSTLQIRGKYLANNITQVRIGGFELSPSEVSENQITLILADVPVDFLRAGVQSLQVIHQIPIGTANLNNGNRSVDSNVAPFVLRPTIKQINIEQQNRPMDDLRSLILSLQVDVMVGIKQRVVLVMNEWSIDEPIGYQFVAEPINIDTDTIIFNLTGVKPATYLLRLQIDGAESLLSIDSDDTSSTYGWFNTPRIEIS
>NC_019751|2803324:2918529|2915808_2917272_+|WP_015198094.1|DBSCAN-SWA
MKKSTAISLHIPPKMWSEFRESMLKSRMFNEEVIGFLFCQRHQVSKSKIRYIPKTWVVPASDCYEHQSTSGLVLKQHFHSYLLENHLQVGLDVVHIHTHTGQGIPDFSHTDDRYESEYARFISSNFPKKPYLISGVFDENLQSGQFRIWDRKGQKFEYLNFCNSLFEVSKFEDVINHDDSIFARQKIFGKGNQKALNQLKVLLIGCGGIGSIFAELLGRLGVKNWVLVDPDRLETTNLNRMPSATQEMVEQQWHKVHYVKHLIKKIYSEGSSVKTIVTTVESELAKQEIATCDLIVVATDNHFSRKTAQELALQYMRPLVCLGTHIDMKSDNTPRMYCRVTVPPLGGAWCLMCGNIINLQRAALESAPLAINQIAANAGYLEGVNDPAVFWLNSICASTGVGVIHGMVSGFLNVDSGIDWIYEFPDGNWRKTNTEYLQNDDCYFCGMGSLEEVVEDSDFEDSDFEDSDFLGSDVEDSDFDNSDFFVW
>NC_019751|2803324:2918529|2898906_2899074_-|WP_015198080.1|DBSCAN-SWA
MSGINLSESIIRHNTNSKSFQRGEICYRDGSVLSVTQRGEEIQAEVQGSEQQPYR
>NC_019751|2803324:2918529|2808610_2809450_-|WP_015198007.1|DBSCAN-SWA
MTTANHFPESLLNIAEEQTAKADQKAKGLQAQADEAASIQKLCQNVTSYLKRGWTLHLLDAIDKQDPLLKKMKVDNHSTISFLEEIYQIAKEEASQIKYHFFPRELEEACRVANLPLDRDSTHPNYKFENGFFQIRIDDHKKTARLSDYELPKLCEVPADVGAIIEAVQREQKRVFGRKFDAKVFLKKLRKQYLEVIKKQKLTDGSSIPIRDITRRLGKNEKGFRTDEFLIDLSRLVEQNFTEIEGRKFEFTQTKDTTQGLLLHIENKRYIGSILFKKV
>NC_019751|2803324:2918529|2847376_2849515_+|WP_083866369.1|DBSCAN-SWA
MVFLPTRSVIQAKLTIGQPGDKYEQEADRVAADVLQRINQPQAMSSNQRETIQRMEVPEEEELQMKPLVNSIQRMEVPEEEELQMKPLANSIQRVEVPEEEELQMKPFLQRQEAIDGGQASTDLESSINNARGGGQALDAGLQQSMGQAMGADFSGVRVHTDTQADQLNKSIQAKAFTTGQDVFFRQGTYDPGSRGGQELIAHELTHVVQQNSGAVQRSPQPEDTLRQHQEIMTGAKAVTSIQRKAYIGDNCDLPANLEKPKNKALHEDGDIRRFNNQQEFETFAAGSAVEGVGQLADKTWVRLPKSMLVLGENHGNPKAPEIIKATNIKKFRYEGFTHHSATRLEKSEELQGVVQESNKKSLEKKGLVAGADEPTHEAEHALPKYARAVADVIELVKKQEKGEKISETSVVAGSDLGEEYSLVKALLSSLLHALIYSKSYSGKFFSHPLKQFYNENQAAVDEAIETLKASEQGKKVPDFSKLKITNTLDSLTTAYETAAKSKVGLTTQKKIDNFKAQLNTVKEPKVTLTNRAKEDDYLRDASMLETIKKAKSSGDRLFVIGDAHRYKLQPLIEGLGLEVMPDTDFVAQQKDLDTYAKSNGKDYGDGDPKSIGKWIRSIQEKWTPDELIKLGWGRESESEEEWEKRKGNNNKGGTAVLTDHNDTTTRYEVVINGKIIDKKTKNFQYKRGDKYTITAISKAEPKAKIVIYQSQ
>NC_019751|2803324:2918529|2871960_2873280_+|WP_015198059.1|DBSCAN-SWA
MKSLLLSLIISSLLVSTAEAAKTSHILKLKETRQCAECDLENANLKQAFLQKANLRTANLKDANLNGADLRGAFLQKADLRGADLRNAKLEDANLQGAKLDGAMLKNTVISDRTVIERKWLDIFRLVNAQVSNLDLSGIDLTGANLNGLDLRNHNLEGANLQNATLEQALLSGANFNRANLQETSFFISDLRNTSFREANLKKGSLQATDLRGANLSQTNLTRTNLSSAYLEGSNLRNSNLNNANLASSILREADLSQSQLRNANLFSADLRKADLSGVNLRGANLRGADLTQTELENGTLRGTKLDGAILREMKLSGANLSRLNLSNVDFSGVNLSNANLRGTNLSGANLSQAILDGANLEGANLSGANLNKAILESANLLEANLSKANLSEANLNKANITRANLSEANLQRTILSEIKLEFANFCGAIMPNASKGKC
>NC_019751|2803324:2918529|2841100_2843299_-|WP_015198034.1|plate|DBSCAN-SWA
MDFDFLPKLPKSDLDDRTFKDLVEECILRIPRYCPEWTNYNPGDPGITMVELFAWLTDQMLLRFNQVPRRNFVVFLEMLGIRLLAAAPAKTELTFYLSATLPKTYEIPPGTEVATLRTETVEAVVFSTDEPLLIGKPKICHFLTGSTDEIEPKILRDRLTNMWTQSQDGSWEGRAQPIFAESPEIGNCFYLVFNPDEPIAGNVLAVKLRGESASSTGINPDFPPRRWEAWNGQHWQQILLQESDDGTRGFSFSDGSQLGMNTLGEADVVLHLPRVFPITYFSSYQGRWVRCVYDRQINSNSRYTASPQLLGIQVRSIGGTVSASHCTLVRDEVLGISNGNPGQKFQLQNTSILPRQEGEYILVLPPAGLPEIWQEVNDFADSKANDKHYTIDSVTGEVQFGFLIREPAQIRSQVELRSKIQVSGVNTLQLKDALQAVTDMERQYGAIPSKGSQIRMVAYRTGGGQQGNVQRDTLQIPKTAIPYVERVTNHISARNGADAESLDNAVMRVPSILRTRDRAVTPEDFETLALQAGGGAVARVYCPRRMNDKSNRGVVDLLVVPQANIEGVNRGEGIHPGEFMLNTALQQHILSYLDERRLLGIEVRLSEPKYVGVSVQAEVGLEPEYNNSQAQQTIIQSLQIALYRFLNPLTGGIDGKGWQFGASLYTSDIISLFQKTTGVRFLGAILLFELHQHGSEWTRALADGGVINPGEFGLICSWSNNQLRSSHAITVI
>NC_019751|2803324:2918529|2905134_2906424_-|WP_015198087.1|DBSCAN-SWA
MFKRFCSQAFGTINVAVGFSSLATIVVGAITVFGSAGLLCLNKAGVKTVPEKRIQQTLQLGMGFTLLGSVGFVSATVAAACIASISGAVDGEESVTSSYTNSVVFESSESIPTQNNTDSLYLYQIMRILGCRHLDNKLIVGRVEDESSRKFVVYDLLDSDSQDSLMELFDLGYDEEKLIGKAFSCQNPNPNHAIREFVDFYRPQLEFKSSCEEFSSFNLETCVGCRNFHGANKIVCGMHPYGWEQDDNCPDWQSNQRRQRVYFPFEREEVISQLNCSIQPNQVSLLKNDDGTLTLWDDHTNRRFQFSWSGVLLNDSDKLLELDEYARLLDYIQYFSVRTVIEFDYSLKVDEFAQQLRGIATVEISDSGINVRVNYCPKLNIHIERQYRFRFDGIPLYPYESIVPQSLKYNYNLVTFIEWLKVNQARVRL
>NC_019751|2803324:2918529|2809810_2811316_+|WP_015198008.1|DBSCAN-SWA
MIQRSLFDAPITLQELESHLWEAANILRGSPVDRTDWKSYILPLLFFKRICDVWDEECQKMIEEYGENFPDEHRFQIPEVSHWQDVRSTSSNVGTALQNALRNIEVANQKHLYGVFGDAQWTNKEKLSDELLKDLIEHFSALNISNKRVHNDVMGDAYEYLIKKFADTTKNKAGEFYTPRSVVHLMVDMLDPQEGETVYDPACGTGGMLLAAVAHVRNKGGDARTFFGKLYGQEKNLTTAATARMNLFLHEVEDFIIERGDTLRNPVFTANTGGLAEFDVVIANPPFSLEKWGREIWETDPWGRAFAGLPTDSSGDFAWVQHMVKSMAKPHGRMAVVLPQGALFRGGIEGQIRRTLLEMDMIEAVIGLAPNLFYGTGLAACILILRQRKTQEKAGKLLIVDASAVFRKGRAQNFLEPEHAAEILRWYQEFTDVEDRARVVSLEEIEKEGWTLNISRYVLPPIGADIPPLEEAIASFKDALVQCREAEERLHQVMLEGGWLE
>NC_019751|2803324:2918529|2838441_2839749_-|WP_015198032.1|DBSCAN-SWA
MISIEPLQRLQVTDGLLLTANLWKQAHDYHRQRQNIYYQSLHQAGIVWGLGVHVIDAPEEVAGQYKDRRWLQIQPGLAIDGKGNPIIVPQALAFRIASEAPAKGSLTVYVIVNYVDPDKLQNQSDRQFVQETFRIDEKTTPPNGTEVELCRILLTPGEVELVNAPDVLQPGINNLDLRSRNCAQLRIQKQVVVTYLADLQKTNPKIVENLTYLLQSMTALYPAMGGKAIEVSSLSETVNKLDSDLLYLTYEQFLSLKVDEEQVQNLQQYLQSGANIFIEVEEALVEELSFVRQQLRSAIANLTQEQESALISQELEAELMRVEEKLQQQLYQIQQPIQELSKQFGIPITNFATLPSHHPLRKEPFLFSQMPTIKNYPIHLFNWGGIILIFGSLSSGWGIDENLSLSREIIRTTQEMGINILHFAWYRHQLIQSQK
>NC_019751|2803324:2918529|2823151_2823685_-|WP_015198020.1|DBSCAN-SWA
MTHTIVAHFPSHVEAERVVLELQKEGFDMQKLSIIGKDYQTTEHVRGFLTWKDTAKTGAAGGAYWGSFVGGLFGILAGAGVLFIPGMAPLIIAGPIVGVLAGWLEGTLIGGASAAAVGGLAGALGGLGIPKHEVLRYETQIQAGEFIILVTGSNEDVSQVKQMLDKMGHKMGMSVAV
>NC_019751|2803324:2918529|2852148_2852376_-|WP_041739448.1|DBSCAN-SWA
MDAEEMLKQQLQQEGDLIGISMLTELGNQAVQLGLIAGHGYHGGKYEILRKGQVILLAPQEAKTYLLNLIAELEK
>NC_019751|2803324:2918529|2906705_2907146_-|WP_015198088.1|DBSCAN-SWA
MILELRFNMLPPALNEQIDLARSDWRASAAVKKTWTNKVANLTQKVDFSFNDKVWIEYHWHLKTFARDSDNVSAASKYILDGLVDAGIIRNDNLIIIQSPVPHYYYRAKSDGVILRLSSAPDFLLENFYKFTQLGIKDMNNNKRQF
>NC_019751|2803324:2918529|2897708_2898878_+|WP_015196004.1|transposase|DBSCAN-SWA
MSNSTQLYSQVLGYLRQYSTYRDLRHLKTLAWMINGLICSGQLSLSAWEPYVDSYAKQAQSYERRWHRFLENIRINVEKIYLPLALLALKDWEKHRLYLALDTTMLWNRFCMIHISVVCCGRAIPLLWRVLEHNSATVAFKEYEVMLRKARWLLRRDSDIMILADRGFANHDFLSWLQKSNWHYCIRIPSDTCLHGVRRYPTHVKSIYPNRGQAAFYRNVGLWQDCLIRCNLVVAYPEVVSEHWAVVTDEEPALKTLHEYALRFCVEELFLDSKSGAFELEDSRIRDAESLERLYLIAALALLYSTTHGMAVQIAGLRTCVDPHWNRGLSYLKIGLRWLKGVIHKGRQLLTPIPLLSQDPQPSFASNKARQDDNLGICFSRIYSFNSWV
>NC_019751|2803324:2918529|2849695_2849905_-|WP_015198039.1|DBSCAN-SWA
MAVQEVTRLFRAAQVNPDLRENLNQAPDEEAFVKMAKEQGYEFTVEEWRKVTGFAVEELKCELSEIPGI
>NC_019751|2803324:2918529|2881680_2881941_+|WP_015198064.1|DBSCAN-SWA
MFQLATKQQASEILNMSFSTLKKYRLDGTWIEGTHWVKLNSRCIRYNLELIQDWLHNRQDPIAHYRAIDLYHAGLASNQKRSQQKA
>NC_019751|2803324:2918529|2885644_2886919_-|WP_015198071.1|DBSCAN-SWA
MRIAIIALGSRGDVQPYIALGRGLKQAGYTVRLATHENFEELVSSHDLEFYPVQGNVQEIIETKEMRELLEKGNFLAITSHTAKLAQDAAIHWANDGLVACQGMDLLLVGVGGQNIALALAEKLDLPLVQAYVFPFTPTKAFPSVLFPQFISKLGGFFNRLSHHLTRQLMWQGFRSADRLMREKVLGLKAAPFWGLYNCDRLHQYPILYGFSPSVIPKPSDWHNTHVTGYWFLDSAPGWNPPSALMEFLESGSTPLYIGFGSMGNRNPEETVDLILSALALSKQRAIMFAGWGGLRKQNLPSTVFLVDSVPHSWLFPRVAAVVHHGGAGTTAAGLQAGVPSIIIPFFGDQGFWGEHVAKLGVGAKPIPRKQLTAEKLAEAIQQVMTDKAMRQRAANLGARIQAEEGIAGAVAVIEEIRKNVTSS
>NC_019751|2803324:2918529|2811312_2812803_+|WP_085953339.1|DBSCAN-SWA
MIAQITQQALESYLWGTATILRGLVDAGDYKQYVFPLLFYKRLSDVWDEEFAQALADTGDDNYARDTANDRFIIPDGAHWKDVRIVAKDVGKALQDAMRVIETANPGRLDGIFGDAPWTNKERLPDSVIKNLLEHFSTVMLSLANVPEDELGNAYEYLIKQFADDSGHTAQEFYTNRTVVYLMVQMLAPKSGDRIYDPTCGTGGMLISALTEVKRTGGEHRTLKLYGQERNHMTASIARMNLVLHGVGDYQVMRGDTLERPAFTESDRLRVFDVVLANPPYSIKQWNREGFQTDPWQRNFLGTPPQGRADYTFFQHILKSLDPKTGRCAILFPHGVLFRKEEAQMRQKLVEADLVECVLGLAPNLFYNSPMEACIIVCRTRKPKERQGRILFIDAVHEVARMQGQSFLKPEHQLRILNAYQSYIDDPGFAKVATLEEIANQDYSLSIPLYVRRTSANNQTEEVKTLREVWDDWEQGSRAFWLEMDALVDMLDSLET
>NC_019751|2803324:2918529|2822398_2823082_-|WP_015198019.1|DBSCAN-SWA
MTNTIEKTDVELKTDVLSELKYEPSIKVTDIGVLVKDGTVTLNGYATTYNEKREAVRAVKRVAGVKAIADDIEVKLPSSMHRTDGDIATAAANQIASCTIIPTKTITPTVREGWITLDGQVEWWYQKNAAGNVVHYLSGVKGVSNNISIKPKLTTMAVETAIQSAFKRSALFDASKIQVETSQNEVVLSGKVRNYSELEEAERAAWAAPGVFSVDNNLTLESFGFDT
>NC_019751|2803324:2918529|2856455_2856929_+|WP_015198044.1|DBSCAN-SWA
MPELKPIPTSRFYVEFDGLTQKLIKSITDFSFTGQTTGHEKPLASTKDGKTLWQTTSGGFKQNPNFTIEVYLAEGDMDFYNWMLATMPKSEGGKGEWSKNRKAGALVAYDSEDAEIMRWKITNGWIKSYKISEFASDSNQLAVETFEVVCEQVDRTT
>NC_019751|2803324:2918529|2884248_2884974_+|WP_015198069.1|DBSCAN-SWA
MKTNHNTVLITGGTSGIGLALAQRFLRERNSVIVTGTNAEKAQAVRHQLPALIVELADMRDRQALEKLVYNYPDVNILINNAGVQYNYDFADPAIAVEKITDELDINLLSPLYLTKLFLPQLLSHSTAAIINVSSGLGIVPKQSAPIYCASKAALHSFSKTLRWQLETTSVRVFEIIPPIVDTAMTQGRGRGKITPEALVEEFWRDFSRDFPEIRIGKTKLLFVLQRLMPTLAERIMRPGL
>NC_019751|2803324:2918529|2877058_2879032_-|WP_015198061.1|DBSCAN-SWA
MKTPENKMTTYSFHKNELYQMTGLVDYSDVRSLPEMWQITSKIFPDIVALIDPHAKPKVTLTYSQLYYQIQQFAAGLQALGIKQHSTESVTPIVALFADNSARWMIADQGIMMAGAANAVRSSAAEREELLYILEHSGSLGLVIENLKTLNKIAPEVYQSQIQWVVLLSDEQPENNSINSSLIIINFEQLMQIASQSSLQPTELAYQKLATLIYTSGTTGKPKGVMLTHGNFLHQISTLTAIIQPSVGDKTLSILPTWHSFGRVGEYYTLGQGVTQIYSNRRYLKQDLQDYTPQYVIGVPRLWESIYEGIQKSFRDKTPRMQKLIKSFLAVSKKYIKAVRTWKKIDLQNLNPTTSQIINAWITTILLAPLHFLGEMIVYKKIQLATGGKVKQLICGGGSLAQHLEDFFEIVGIQILVGYGLTETSPVLSARRYYKNLRGASGLPLASTELKIVDLETHQPLPQGKRGLVMAKGPQIMQGYYLNPEATSKAIDSEGWFDTGDIGWLTPDNQIVLTGRAKDTIVLTNGENIEPQPIEDACLRSDYIDQIMLVGQDQKSLGALIVPDLEILESWLLSKNQPIVNGEIGLNNQMIRDLIREELNREVRDRKGYRRDDEIIVFEIIPEPFTIENGLLTQTLKIRRNIVTDRYQGVITQMFSR
>NC_019751|2803324:2918529|2861120_2864171_+|WP_015198052.1|DBSCAN-SWA
MTEDFERSHFTQTAENQVQPSLINPDVTTSPEIQLQQLDFKQTAENQVQPSSINPDIVDSPEIQLKQDSIGNVERSHFTQTSENQVQPSSINPDVTDSPQIQLKQDSIELGLRSHFPQTPENQVQPSSINPDVTTSPEIQLKQDFTEDFKRSHFPQTPENQVQPSLINPDVTDSPQIQLKQDSIELGLRSHFTQTSENQVQPSSINPDVTTSPEIQLKQDSAESFVRSHFTQTSENQVQPSSINPDVTDSPEIQLKQHLTEDFKRSHFNQTAENQVQPSSINPDVTTSPQIQLKQDSIELGLRSHFTQTSENQVQPSSINPDVTTSPEIQLKQDSAESFVRSHFTQTSENQVQPSSINPDVTTSPEIQLKQDSAESFVRSHFTQTSENQVQPSSINPDVTTSPEIQLKQHLTEDFKRSHFPQTPENQVQPSSINRDIADSPEIRLKQDFTESFVRSHFPQTPENQVQPSSINRDIADSPEIRLKQDFTESFVRSHFPQTPENQVQPSSINPDVTTSPQIQLKQESHFTQTSENQVQPSSINPDVTTSPEIQLKQDSTEALVRSHFPKTPENQVQPSSINPDIVDSPQIQLKQDLTEDFKRSHFTKTAENQVQASSINPDTTASPQIQLKQDSIEYFVRSHFNQTAENQVQPSSINPDVTASPEIQLKQDLTEDFKRSHFTQTSENQVQASSINPDIVDSPEIQLKQLDLNQTPENQVQPFSINLDVTTSPEIQLKQDSMESFVRSHFTQTPENQVQPSSINADVTTSPQIQLKQDSTGNVERSHFNQTSENQVQLSSINPDITTSPETQLEKLDFKQTPENQIQASSSNTDINSEKSNIHEDKIRELPQVLQKLSILNPIAQRKSINESQQKLDFTTTNIDSKASNINNQISTLQTKLDATPIFSTVSNKNSSSNSSQWSDFNSLIRGQTTPSKRRNNHISESKTTAIQAKMSENIEPIRVSRKEDFQAEYENNSSNNVSKNELEIVAQAIYQQLKQRIRIEFERHGQGSLGRLPW
>NC_019751|2803324:2918529|2828701_2828947_+|WP_015198024.1|DBSCAN-SWA
MLQSYEAIIENGQVKWLTDAPKVSKARVIVTILPDTVARDSTGVATRTQGRVPASTIAGKGKTLGDLVSPIVSEQDWECLK
>NC_019751|2803324:2918529|2882394_2883201_-|WP_015198066.1|DBSCAN-SWA
MAQYLITQLQEQLAQADDSKTKEWWEAYLKHSLPFRGLKLPQVRAILHSWAKTANFSSQPVTQQFDTAIALIQESWGEDKLAGILLLQEFLLKHRLINWESDLPKFATLFDEAYIKEWNTCDWLCVKVLNPLIKQQGKSCAEAIMQWCEAENLWRKRASVVSFVNIAKHGESNFPGFTQMLLHSCGVVVQSSERFAQTGTGWALRELGLSDRNLVIDFIKTNSTYFSSEGLRYGMEKFPPDLQQQLKQYRQEKLKSKNNPKSNISCLP
>NC_019751|2803324:2918529|2825116_2825251_-|WP_015198021.1|DBSCAN-SWA
MRIQSGNSRLPEKMAASLKSPVQLNKVVESIRSQLTGVKVYLSL
>NC_019751|2803324:2918529|2829905_2830352_+|WP_015198026.1|DBSCAN-SWA
MIKRLWRWLEKFYDAYLSLRLSSLLSRNFQLLAEVNDEDWSHGRVKGFLDGKNIAEADLLQWLRRSGENLLASDGENRELATRMVRLGEVDCGELGEIASEIGRKLLGKCIEEETNKEKALLSKNGTSGKKGILKTPEIVSKLNANRL
>NC_019751|2803324:2918529|2896134_2896467_+|WP_015198078.1|DBSCAN-SWA
MQQLGTPISFVGIDVSLVTVLLQEEHPDLAHLPIHLVDAGWDNAIFRLGEDLSIRLPCRQVAAKLIENEQTWLPKLSEILKSTCFIPFLWILTISAKSLDIMTKILVNKK
>NC_019751|2803324:2918529|2816300_2817839_-|WP_015198014.1|DBSCAN-SWA
MKPDYLIVGSGLSALVFGALMAKSGKTVQILEAHEHPGGFGHTFTMAKKYTFNAQFHYVWDCGEGQTVNRVLKKLGLEQEVTFERYDSEGFDHMRSPEHSLDIPSEPEELIQRLSALFPAHGDLIRKFVNEVEKTGAGLKKLSPPIKPIELLKHSNEVFSAVQYLNSTLQDVFDKFQLPQAAQTLLALQWPDFLLPPNQLSFYAWVILFRGYQAGAFYPTQHFEHVINSLVNVIESHGGQVLLNHEVTNFRVTDRTVTGVQAMDLTTHQTHEFTGDTVICNIDPKKAAKMIGESQFSKSVRRKLNYEYSASNYMAYCVVKDIDLREYGFGKWNLFHTGHHDLNEAFAQMYDRNDFSNPSFAITTPTLLTTASGDCPEDSQIVEFLTVANYNYFQELRDNDRKAYNQKKQEILDSILDVVEEHYVPNFRKYMVFHITGSPTTNERFCWCPNGNSYGSSLIPRNMGMGRLNHETSLNHFYFCNASSGYPGFAATFWTGALLYQRLSGDMILGNS
>NC_019751|2803324:2918529|2806880_2807348_-|WP_041740462.1|DBSCAN-SWA
MSTEVQGVIESLRLGIPPSGYIRYFTVGRISEIAQLTARLQQEKSGALLLKANYGSGKSHLLRFIRETALKEGFAISSVTLDAKSGIRFNRMDQILGAIWRGLEIPGNAENKGVRPFFDFVCQQARSSTGTKGDEWAKITNKGQYLCQIKRIQRP
>NC_019751|2803324:2918529|2892541_2894209_+|WP_015173935.1|transposase|DBSCAN-SWA
MSPTSIAEIKNIDHLGIVAGLIDEIGIVETINSKLGVDSREKITAGVLVKAVLINGLGFVSRPLYLFKQFFDDKAIELLLGEGVESNYLNDDKIGRVMDDLYKYGLNNLFIEIVLSVIKKFKIDTKYSHLDATSFHLHGKYKREMNQEKEEEITKERPIFITKGYSRDHRPDLKQCVLDLITSSDGDIPLLMRAGDGNEADKAVFGKILIEFKKQIVFDSIMVCDSALYSQENLKLIENLKWISRVPMTIKKAQELVQSVNTEEMEEIEEIETEEKEIETEEKKKKTYQDLDGYKWKEEIVNYGGIKQIWLIVESQKRKDSDLEKLDKKLIKEKDKVEKLLKELKREDFETPEQARYKLKGINKKLKFHEIKEANFIESKSKNNKTIYKMEGVSYEKPEEIEIQRKEAGRFILATNLVNDDDKLKPEEIITTYKNQQSCERGFRFLKDPLFFADSFFLENPERIETMLFLMSLCLLVYNLGQRELRNSLKRIKIGIKNQLGKLTLSPTLRWVFQCFQGIHFLMLDGLNQIVNLTSERHFILSCLPSSCQKYYLLS
>NC_019751|2803324:2918529|2904410_2904902_-|WP_015198086.1|DBSCAN-SWA
MFEFLFDCSAFEISTTTQLLNNILFPIVLFLVIFWLMCEIFLVDDNLPMVDEEFTSGVIKTQIDEDILNPADESNIDKLLANMAATIDQKQSKTALFDIDRESESLKALGVRQLRDFCKNRKIKGYAAVYNQGGINGLVEFLLQQQIYARDIEQQVKHLEISA
>NC_019751|2803324:2918529|2859430_2859955_+|WP_015198050.1|DBSCAN-SWA
MAKSIDEDYGLNLISANRFYVGIESNISASFTECQGLGVKVKYETYHEGGVNDQQRIFLGQPEFSEVTLKRGMSDDLVFWQWASQLMKTDASKSIERRNVNILVFNQAGETMQCWTLIGAAPVGWKAPSLTADSSNIAIEELNLIYEGIKVVKKSGAASATPINRSATGYFGSN
>NC_019751|2803324:2918529|2823793_2824216_-|WP_041739441.1|DBSCAN-SWA
MNTTIDNFTKQLHGNLEAIENRAKSLRESVQSAPKKTQAEIQSKLDEAKAKLEAKKQEFDEYRAKLKTQFEEKESEVKSHVEEWKATRKVKKLEHRADKAEDYAATAIFLAMAAMEEAEEATLSAICSRLDVETAAGTTK
>NC_019751|2803324:2918529|2864213_2864720_+|WP_015198053.1|DBSCAN-SWA
MSLTKAKLVSSDGGGTIEFMFNPTQLKFSQSISLNKNEGARTGRGLPKVNFAHPQPCTLSIGDIILDTYEQGSNKSVLPYIKQFEKAVNFLEQGCEKDKRPPTYVFTWGNYQYIRCFITNLAYTLTMFLPDGTPVRAKLDLTLEEIDESTSQPGMGTPSNPDRIGGGR
>NC_019751|2803324:2918529|2867498_2869997_-|WP_015198057.1|DBSCAN-SWA
MKFQKVPQIILKPFVKNYLNKYSRVLKHTKYNALMRWSWMQPILEDLKGELFADEAETVEETAKTITPPPDLPREAGVQFFDSPYQRYACVCNDPLQCDRALPITQAGDKTQACTSCGFPALLAEPVLIPNLPEPKQQKIAGLRGVYRIERWLGRLGMGRIYAATQLGINQPVIIKEYLLPGRYFNAEEIYKQLQLFKSVAGICLADGRVQDFRFLQPIEAIIDESQGRCYLVMDERYACPTLNNYLANCRGREEREKGKGEGEIRVRGNKENKKNQGMSSSQVHLVLNQTLQTLEFLHGQKFRFPSAQIQNGVVHGNINLDSLLMVKSNHNGYEQSLKVIDEDTIIGSLIVEDLDFFIYLCDLAIWERIFIPISETSVKNNFKDKLENADKPQDLISLGYIAFYLLLGKVISDAGYAIDPENETHWGDINPHLKKFIRRLIKGEFISAEVARQELLKLPKAAFEVPVEFSAEAETETRTKFPRLLIFLLTTLGLGVIGGLAWLFFAKPQLSNATSNTPQLNLIKEVGAIPIGKFTYTASKNGIWDYIIQQSDLIQKGQTLEQRITIAQPKLQLSYEPTTSTEEAIAQVQSGKSAFAIVPLIQPLPADLQAQPIAYDGIGVFVAFSYSQREKGLPEKLNGQITVDKLQQLYAGNISNWQELGGPNLAVNIYAPVDKEVQQVFIQQLLKTIKSKENSLKTSQELQEFEMMRTVLRDFESQQAGGIGFGSLSKIIGQCSVYPLALQIEGKPPIQPVILSNNQSIEPNTDLCDRKGSYHPNSELFRTGRYPGAYAIAVVYPIDNNRSPIGEKFAQVLKTKEGQRLLKLTGLVPLE
>NC_019751|2803324:2918529|2830555_2833129_-|WP_144051037.1|DBSCAN-SWA
MVNNNLNSALSTFNFDTTDRLQNLAIKPLAVIISASGQDNVTPGSTFHLSMMVTNKGNQSAVIEVYIQEESKGLRQWCKSGQKLLALGSDRSEEVIFEFDIPIDTLPGLYNYIVVVDAPDDYPEYTPIQYQQYLQIVPATADIINSSDPTFISYPTTSPDSPSIIQPGGALAVQILVQNRGDRVDKFRLICTDLPKNWVNITYPQVFQGTGLIIETDCLNLNPGENGQISLLINPPISTLAGKYIPTMRLHSENNPELKLLDLLYLEVAPTYQLQTELRSIISRVKSKTGIYQLRLTNTGNTPRKINVKVQELEENHICNYTLEQSQALILPQQTVAVDLQIKPKNRWQRPFIGGPRIVNFNIDLFDHQELPLAPNNFPGMLLWEARPWWQILPLILLMLLCLGTSAYFIWWFLFRIPPSPKIWQFYPEDSAYAAINADTVSLGFEISDINRLKSLKIVGISADGKPLTRPQEYDFSQGVPATLQSFCTQQKNLLNCRNVRTGARKPGTYIFEMSTQPKPGRGAATDNIKTNPVAIAPIPQPEIIAFGSTQPTYQEFSLLNPNQKEAKNNPKSLNKDFQIRLNWAIRNASQLRMVQLIGRTPDGLAVTPVKNFDFSQGIPSQLKKFCAAGEPLVCFNMTTNLKKPGDYIFELKAISQDSENQKLEPSKTELIKIIPKPPQIISFKINGKPAPTKLMVPITPGKPVPKIVLSWEIDASEGTKVELQPAPGTVRLKDSISFPLEPKPASIPISLQVTTTTGQQIVRSLILETYDPKAKDPAIVAAEKMAEAISKSQKEAAESAQADQKEAAAKAANTEKNTPANAANINAAPGSVPEDEEDNTKSKNPPTLLPIPLPPQ
>NC_019751|2803324:2918529|2915172_2915658_+|WP_015198093.1|DBSCAN-SWA
MAVTISQEKAGFKPSQRIIEELKLLEKVARNVIVGSKTVGDIKYIAVLIKGMPLSSKKFTVSNTDVLFLLPPDYPRLPPIGCYLNYPWNTLGEGDHHFTRQSYYGAPFLSEEGWYWYCVGLGGGFNHDVWLNSWRPSNNPENGHNLATLFVTARHAINSDD
>NC_019751|2803324:2918529|2890894_2891560_+|WP_015198074.1|DBSCAN-SWA
MAESSSSSSGMRRKPRQARSQERVSRILDVAEELFIVEGYTATTTNAIATRAQVPIGSLYQFFPDKTAILKAIALRYGELLHQKFAAFDGVELAKLPLSTYVEKLIDTADQFFTDNPGYHAIFMEVQGTIPELEEIEEAADAQLIQDLLTSLSQRDSTLEPADYEAIAFVLVKAIGMLLWLSLSQEIRLRQRLVAETKRFTLNYLQSYFPSDSLPATTEAD
>NC_019751|2803324:2918529|2821812_2822166_-|WP_015198018.1|DBSCAN-SWA
MVNKIDVNKSVPQDRWGEFFDQFSDGNRGRHISLEIIGSELGDEELIKNAPLMAMVYDPPGKGDDLLIEIGRDEVTYAHTIDSPTEVLTAQNSNGVMMAVSVTNVAGTKTLIKLQAT
>NC_019751|2803324:2918529|2825411_2825666_+|WP_015198022.1|DBSCAN-SWA
MTLIKKSEQQLLLKIKKIEDEEQNIQPDTRDIPEVREEEKQLITENTESNYIPARDNPIVQSIGNSGWQISDIWRDIRVDNFSD
>NC_019751|2803324:2918529|2897265_2897598_-|WP_051036653.1|DBSCAN-SWA
MTEVNCKAELNNIIKQYEQRLSSPRPNPNEEFERLLPTCKPGGSRFQNQNYKTFFAGKDLLYGMREELSRFGFQSPVVFRDSILKGIEETVEDVWMWLPEWNSLRELLLR
>NC_019751|2803324:2918529|2859234_2859393_+|WP_015198049.1|DBSCAN-SWA
MGEEKLINIDEIAKKIVQDPILMQKLSDRVLELLREDTRVLKERCQGYGNRF
>NC_019751|2803324:2918529|2814958_2816233_-|WP_015198013.1|DBSCAN-SWA
MKIAIVGGGASGMVTAYLLDKQGHSVTVFERQSTLGGHIQTLNKNVHPNQSDCQEILENGVLEFPTVFHNFIALMEQLGVELEPVNMSSAIFFKNGSHFLSKIAIKKNFTGIRHLIEYLRLDTLYARSAGFWLRIRFAHLQDFYNQPLSQYLKRPCTRNTWLKLLVMYSYSMPLELIDDFPAELAMPVLLKDVAVSWVRIKGGVYSYIEKILARFKGEVLLNVQIDRIFRTSDAVKIVRRTGEIQEFDKVVFATPPDQVMALLADPTDAEIKRFSAWKANYATTLLHTDSSIYTRYGIKQPSEFDFFETESRWGYNSCLNQICDISSPPNYFLSFQLEELIASNRIIHIQEHHTPLYTTESFQYRNEVVATNGENNTYHAGAYLGDGLHEGAIASAFRVAQLVGLSQGAISITNCKSTPQFVQN

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015198003.1|2803324_2804860_+|transposase	IS66 family transposase	NA	NA	NA	NA
WP_051036650.1|2804948_2805461_-	hypothetical protein	NA	NA	NA	NA
WP_015198005.1|2805562_2806903_+|transposase	IS4 family transposase	NA	NA	NA	NA
WP_041740462.1|2806880_2807348_-	DUF2791 family P-loop domain-containing protein	NA	NA	NA	NA
WP_015198006.1|2807351_2808608_-	DUF2791 family P-loop domain-containing protein	NA	NA	NA	NA
WP_015198007.1|2808610_2809450_-	hypothetical protein	NA	NA	NA	NA
WP_015198008.1|2809810_2811316_+	SAM-dependent DNA methyltransferase	A0A220A2U4	Liberibacter_phage	8.4e-134	50.9
WP_085953339.1|2811312_2812803_+	SAM-dependent DNA methyltransferase	A0A220A2U5	Liberibacter_phage	2.7e-132	54.5
WP_015198012.1|2814256_2814706_-	hypothetical protein	NA	NA	NA	NA
WP_015198013.1|2814958_2816233_-	NAD(P)-binding protein	NA	NA	NA	NA
WP_015198014.1|2816300_2817839_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_015198015.1|2817991_2818993_-	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_015198016.1|2819027_2820599_-	oleate hydratase	NA	NA	NA	NA
WP_015198017.1|2820648_2821677_-	zinc-dependent alcohol dehydrogenase family protein	NA	NA	NA	NA
WP_015198018.1|2821812_2822166_-	DUF5335 family protein	NA	NA	NA	NA
WP_015198019.1|2822398_2823082_-	BON domain-containing protein	NA	NA	NA	NA
WP_015198020.1|2823151_2823685_-	hypothetical protein	NA	NA	NA	NA
WP_041739441.1|2823793_2824216_-	hypothetical protein	NA	NA	NA	NA
WP_015198021.1|2825116_2825251_-	hypothetical protein	NA	NA	NA	NA
WP_015198022.1|2825411_2825666_+	hypothetical protein	NA	NA	NA	NA
WP_015198023.1|2825970_2827872_-	DUF3370 family protein	NA	NA	NA	NA
WP_015198024.1|2828701_2828947_+	hypothetical protein	NA	NA	NA	NA
WP_015198025.1|2828934_2829336_+	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_015198026.1|2829905_2830352_+	hypothetical protein	NA	NA	NA	NA
WP_015198027.1|2830352_2830550_+	hypothetical protein	NA	NA	NA	NA
WP_144051037.1|2830555_2833129_-	hypothetical protein	NA	NA	NA	NA
WP_015198029.1|2833248_2835486_-	hypothetical protein	NA	NA	NA	NA
WP_015198030.1|2835697_2837098_-	HAMP domain-containing protein	NA	NA	NA	NA
WP_015198031.1|2837184_2838273_-	DUF3365 domain-containing protein	NA	NA	NA	NA
WP_015198032.1|2838441_2839749_-	hypothetical protein	NA	NA	NA	NA
WP_015198033.1|2839993_2841043_-|tail	phage tail protein	NA	NA	NA	NA
WP_015198034.1|2841100_2843299_-|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_041740468.1|2843430_2843778_-	four helix bundle protein	NA	NA	NA	NA
WP_015198036.1|2843870_2844272_-	GPW/gp25 family protein	V5YTB2	Pseudomonas_phage	2.0e-10	47.6
WP_015198037.1|2844649_2847112_+	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_083866369.1|2847376_2849515_+	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_015198039.1|2849695_2849905_-	Nif11-like leader peptide family natural product precursor	NA	NA	NA	NA
WP_144051114.1|2850064_2852098_-	AAA family ATPase	K9MCS8	Sulfolobus_virus	1.4e-06	31.4
WP_041739448.1|2852148_2852376_-	hypothetical protein	NA	NA	NA	NA
WP_015198042.1|2852649_2853921_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_015198043.1|2854595_2856302_+|tail	phage tail sheath family protein	A0A127AW39	Bacillus_phage	2.7e-19	29.5
WP_015198044.1|2856455_2856929_+	hypothetical protein	NA	NA	NA	NA
WP_015198045.1|2857033_2857507_+|tail	phage tail protein	NA	NA	NA	NA
WP_015198046.1|2857610_2858099_+|tail	phage tail protein	NA	NA	NA	NA
WP_015198047.1|2858360_2858678_+	hypothetical protein	NA	NA	NA	NA
WP_015198048.1|2858703_2859069_+	hypothetical protein	NA	NA	NA	NA
WP_015198049.1|2859234_2859393_+	hypothetical protein	NA	NA	NA	NA
WP_015198050.1|2859430_2859955_+	hypothetical protein	NA	NA	NA	NA
WP_015198051.1|2859958_2861137_+	hypothetical protein	NA	NA	NA	NA
WP_015198052.1|2861120_2864171_+	hypothetical protein	NA	NA	NA	NA
WP_015198053.1|2864213_2864720_+	hypothetical protein	NA	NA	NA	NA
WP_015198054.1|2864802_2866764_+	VgrG-related protein	NA	NA	NA	NA
WP_015198055.1|2866946_2867342_+	DUF4280 domain-containing protein	NA	NA	NA	NA
WP_015198057.1|2867498_2869997_-	serine/threonine kinase	NA	NA	NA	NA
WP_015198058.1|2870153_2871908_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_015198059.1|2871960_2873280_+	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_144051038.1|2874136_2874481_+	hypothetical protein	NA	NA	NA	NA
WP_144051039.1|2874459_2875221_+	hypothetical protein	NA	NA	NA	NA
WP_015195997.1|2875785_2876799_+|transposase	transposase	NA	NA	NA	NA
WP_015198060.1|2876881_2877037_-	N-acetyltransferase GCN5	NA	NA	NA	NA
WP_015198061.1|2877058_2879032_-	AMP-binding protein	A0A1V0SBX8	Catovirus	3.1e-35	25.1
WP_015198062.1|2879324_2880713_+	OFA family MFS transporter	NA	NA	NA	NA
WP_015198064.1|2881680_2881941_+	hypothetical protein	NA	NA	NA	NA
WP_015198065.1|2881951_2882407_-	hypothetical protein	NA	NA	NA	NA
WP_015198066.1|2882394_2883201_-	DNA alkylation repair protein	NA	NA	NA	NA
WP_015198068.1|2883543_2884158_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_015198069.1|2884248_2884974_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_144051115.1|2885133_2885481_-	hypothetical protein	NA	NA	NA	NA
WP_015198071.1|2885644_2886919_-	glycosyltransferase family 1 protein	A0A290DBR0	Phaseolus_vulgaris_alphaendornavirus	2.4e-12	25.2
WP_015198072.1|2887081_2887705_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_085953324.1|2888011_2889468_-|transposase	IS5 family transposase	NA	NA	NA	NA
WP_015198074.1|2890894_2891560_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_015173935.1|2892541_2894209_+|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_015198076.1|2895424_2895778_+	hypothetical protein	NA	NA	NA	NA
WP_015198077.1|2895790_2896126_+	XRE family transcriptional regulator	NA	NA	NA	NA
WP_015198078.1|2896134_2896467_+	hypothetical protein	NA	NA	NA	NA
WP_015198079.1|2896476_2896914_+	hypothetical protein	NA	NA	NA	NA
WP_051036653.1|2897265_2897598_-	hypothetical protein	NA	NA	NA	NA
WP_015196004.1|2897708_2898878_+|transposase	transposase	NA	NA	NA	NA
WP_015198080.1|2898906_2899074_-	SWIM Zn-finger protein	NA	NA	NA	NA
WP_015198081.1|2899171_2899747_-	hypothetical protein	NA	NA	NA	NA
WP_015198082.1|2899820_2901218_+	9-cis-epoxycarotenoid dioxygenase	NA	NA	NA	NA
WP_015198084.1|2901328_2902369_-	hypothetical protein	NA	NA	NA	NA
WP_015198085.1|2902500_2904210_-	DEAD/DEAH box helicase family protein	A0A2H4J643	uncultured_Caudovirales_phage	1.3e-53	28.1
WP_015198086.1|2904410_2904902_-	hypothetical protein	NA	NA	NA	NA
WP_015198087.1|2905134_2906424_-	hypothetical protein	NA	NA	NA	NA
WP_015198088.1|2906705_2907146_-	hypothetical protein	A0A0A7RTR1	Clostridium_phage	2.1e-05	35.4
WP_015198089.1|2907135_2909151_-	DNA translocase FtsK	A0A218M9A2	Mycobacterium_phage	2.7e-42	32.2
WP_015198090.1|2909155_2909956_-	hypothetical protein	A0A0A0P1Q4	Enterobacteria_phage	2.2e-16	36.3
WP_041739464.1|2909957_2910599_-	M23 family metallopeptidase	G9BW84	Planktothrix_phage	9.4e-26	46.8
WP_015198005.1|2912464_2913805_-|transposase	IS4 family transposase	NA	NA	NA	NA
WP_015198091.1|2914410_2914794_+	hypothetical protein	NA	NA	NA	NA
WP_015198092.1|2914866_2915064_+	hypothetical protein	NA	NA	NA	NA
WP_015198093.1|2915172_2915658_+	hypothetical protein	NA	NA	NA	NA
WP_015198094.1|2915808_2917272_+	ThiF family adenylyltransferase	NA	NA	NA	NA
WP_015198095.1|2917497_2918529_+|protease	M48 family metalloprotease	NA	NA	NA	NA

Sequences of DBSCAN-SWA_4

Nucleotide sequences of DBSCAN-SWA_4

>NC_019751|3927849:3988730|DBSCAN-SWA
CTTAAAAGTTCGCTTGTGCGGTAATCGCATTCTGTAAGCGTGGTTGATCTAAACCCAATTGATTTAACAGTAACCATGATTGAATCAAATCAGGTCCATGGACTTCCCCTGAAATAGCAGAACGTAATGCTTTCATGACTACACCCTTCTTCAGGTTTTGAGCTTTCATCACCTGCTTAATTATATCCTGAGCGCTGGCTTCTGTAAGTTCTTGTCCCTGTGCGAGAATTTTTAGAACCTCCTCTAACACAGTCACTGAACCCGGTTGCTGTAACTGGGTTGTAGCTTCTGGTTGAAATTCAATCGTATCACCAAAAAAGGGCTTAGTCATTGCCACTGCGTCAGTCAAACGTGTTAAACTTGCACCGATGAGACCTGTTAGTTGTTCCAACCAAGCGCGTTCATGGCGTTTTCCATCCAGCTTATATCCAGCAGCTTCCCAAATAGGAATCAGCATATCTGTTAATTTGTTAACTGGCATTGCGTGAATATACTGACTATTGATCCAGTCCAGCTTTGCCCAATCAAATTTTGCTCCAGCTTTATTTACCCGTTCAAAACCAAATTGCTGTGCAGCACCTGCCAAACTAAAAATTTCTTGGGTAGAATCCACTGGAGACCAACCCAGTAATGTCATATAATTTACTAATGCTTCTGGCGTGAAGCCCATTTGTTGAAAGTCAGAAATCGACGTGACTCCATCTCGTTTGGATAACTTACGTCCTTCTTGGTTCAAAATTAGGGGAGTATGGGCAAATTCTGGAACTTTAGCACCAAATGCTTCATACAACAAAATTTGCTTTGCTGTGTTGGCAATGTGATCTTCCCCGCGAATTACTTGGGTGATATCCATATCCATATCATCCACCACCACTGCAAAATTATACAGCGGTTGTCCCACTCCATCTTCAGCAGCGCGGGCAATTACCATGTCCCCACCCAAGTCCCTACCCTGCCAAACCATTTCACCCCTAACTAAATCATGCCAGCGAATTTCCCTTCCATCGTCGATTTGGAAACGAATAACAAAACTACGTCCTTCAGCTTGAAAAGCAGCTTCCTGTTGGGGGGTGAGGTTACGGTGACGGTTATCGTAGCGGGGTGCGTCTCCCTTAGCTTTTTGTAGTTCTCGGAGGGTATCTAATTCCTCAGCAGTGGTGTAGCAGCGATAAGCTAAACCTTTATCCAGCAACTTTTGTACTGCTTGCTTATAGATGTCCAAGCGTTGTGACTGGAAAAATGGTCCTTCATCCCAAGTTAGACCTAACCAGCGTAAACCATCTAAAATATTGTCGGTGAATTCAGCACGCGATCGCTCTTCATCTGTATCCTCGATTCTCAGGATAAATGTACCACCATGATGACGAGCAAATAACCAGTTAAATACAGCTGTTCGCGCTGTACCAATATGTAGACTTCCGGTGGGACTCGGTGCAATACGAACTCTAACAGTCACAGCAAATCCTTTTTTTTGTAAAGCTTTATTAATTTAACTTAAATCAAGTACCATGCATCAATTAGTGAGCAATTGGAATAATCTCAATCAATTGCTCTAAGCACGACCATTAACGTAAACAATAGGTATTTAACGGGACTGACGGGGCTCGAACCCGCAACTTCCGCCGTGACAGGGCGGTGCTCTAACCAATTGAACTACAGTCCCTCAATCGGCAACTTAACTATTATGCCAATGCTGGATAAATTTGTCAACTATATCGGACAATTTTTTTATGACTGACTGCTTGCATATAAGATTTTGTCAACAAATTGACTCATAACACGGCTTTGAATTTCTTTGTAGTGTTGTTTTAGCAGGTTTTTGCTCAACTGAAAATTTCCTGCTGGTGCGGATGGAAGAGTTTGGGACTGTTGTAACCAGGTTTTGAGCATTTGTCGTTGTTGTAGGCTGATGGTGGCAGCTAAAACAGTCAAACAATCATGGGGTGGTTCCTGGGTATAGCATATCAACGGATAGCGATCGCACTCAGCCAAAGATCCTACTAGTTTTAAATGTTGGCTATTCTGCATATCCAAATAACATGGTAGCCATTTTTTCCCATATTCACGACTATAAAGTAGAGTCACCCACAACAACGTTGGATAGGGTGCAGCAATAAAAGCAAACTCGTTATAGTGAGTCGATGTAACATATTTTTCAATTTCCGACTTAGACATCATCAGTGATAAAGCTGTGATCTTTCCATTTTCCGTATTCAGATGGAGGGGAAATACAATTTGTCGGATTGGTTTATCTTTACTCCAAGGAAGTTGCCAACAAGCTTTTTCAATTGTTTTACTTAAACCAGTATTGGCTAATGAATATTTATTAATTATATTCGGAGACGATTTAGCAGCTTGGGTATATAAAGATGGTAACTTCATCGCTGAGTTTTTCAAATCTTGAATAACTGCAATTAATTCACCTATCCTCTGGGGACGATCTTGAGGATTTTTTGCCAAACATGCCATAATTAATTGATTCAATTCTTGGGGAATCTGAAGATTAGGACTAACAGATGTAATAGTACGGGGTGACTGAAAGTGATGTGCTGTATACCACGCTCCCAAATAATCAGTATCTGGTTTCCATGGTTTATGATCTGTAAGCATTTCAAACATTAATACACCCAAACTATATATATCAGAACGACAATCTAGTTCTTGATTTTCTAGTTGTTCAGGAGAGCAATAGGGCAAAGTTCCACAAACATCTTGATGAGTTTTAATCAATGTTGGATTATGGGAAAACTTGGCAATCCCAAAATCTAATATTTTCACTAATTGACCTAAAATTAAGTCAGAAACAACTAATATATTTGCTGGTTTGATATCACGATGAACTAACGGAGATATCTTGCCATCTATATTTATCCCTTCATGGGCACATTGTAATCCTAAACAAATCTGAAACGTAATATTGAGAAATGTAGGTAAAGACAAAGGTAGCAAATCGCTTAATGTTTTACCCTCTAAATATTCCATTATATAATAAAGCTTTCCGGCATTACTGATTCCATAGTCAGTCACCTTGACAATGTGAATACTACGTTGACTCAGAATTGCACATGTTCGTGCTTCATGGGCAAAATCAGCCTGCATTTTTGAGTCTGAAATCATACCAGACAAAAATTTGATTGCAACTGGTGTTCCTCCCAGCAAAATATCATGAGCCAGAAATATTTCTCCCATTCCTCCAGTTGCAATTAGTTGTTTCAACTGATAGCGATTAGAAATCAGTTCCCCTTCTTGGGAGGAAATATCAGTTAACTCTTCCACCTTGAATACCTCAAATTTTATCTAAATAAAGATGTAGCGATATAAATAAAAATATTTTTGAAGATTTTACATGATTAAAAATTGGTAATATCTAGCTTATACATCTAGAATACGGGACGGGATAAAGCATTGAACGTCCTAGAGAGGATTTTTTTAAACCACTGCTTCATACCAGTTTTCAAGGCTTTGTTGTTTTCAGCGATCGCACCAATAATTTCTGGCTTAATTTTCTCATAGTGTGACTTCAGAATGGCTTTACTATCATCAATAGCAATCAATGATTTTGTTTTTTCGCTTTGTTCTAACCAATCCATCAGTGCTTGACGCTGATATGCACTCAACATAATAGTCATCACATCTTGACATTTTGTTGGATCTTCCAAAGCAAAAAATAATAAATGATAATAACCATTACTAGCTAGAGATTGAGCAACTTTTTGACTTTTACTATCTTGAAGATCTAAAAAATAAGATAACCAGCGTGTTAAACCAAAATCACCATCACATAATGCCGTCACCCACAAAATAACTGGATAAAGGCTCGGCTGATAAATAAATTCTGTACAATTAATTTGTTTGCTTAATTTTGAAATTTCAGCTTTGGGTAGCATTGCCCATAGAGTTGGGATACTACCTTGATTAGTTTGTAATAGATGAGGAAAGCAAATTGGTGATACTGGTTTATTACGGGGCCAGGTTTTTTGCAAACAAATTTTTTCTGTAACTTCAGTTACAGGAACTAATTGTAATGCTGATGATTTAGAAGTGAAATTATTATTAGCTACATGTGTAACCTCACCATTAAGATACTTTTGAATATCTTCTAATTTATCTAAAATTACTCGTAAATTGTGAGGACGATTTTTGACATCTTTTGCCAAACAACTCAAAACTAATCTTTGTAAACTATCTGGAATCTCAAGCTGAGGAACAATTTCTGAAAAATCGGGTGGTGTCTGAAAACGGTGTGCTTGATACCAATTACCAAACGAGTTGCTGGTTAACTCAAAAGGGTGAATACCTGTTAACATCTCGTACATAATTACACCCAAACTATAGATATCAGAACGCACATCTACTAGTTTTCTCCCTTCCATATGTTCTGGAGAACAATAAGGTAAGCTACCAATAAAAGCTTCCGTTAATGTCATTCCCGCTCGTTCAGTTAAAAATTTAGCAATTCCAAAATCAAGTATTTTGACAACTTTACCCACTTTGCTATCTTCAGCGATAAATATATTTTCTGGCTTAATATCGCGGTGCAAAACTGGATATATTTCTCCTTTTAAATTAATACCTTGATGAGCGCATTGTAAACCCAAACAAATTTGAGTAATAATTTTGATAAACTCAGAAAGATCTAAAGGCGATGATTTAATCAACTTCTTCAAATTTGTCCCTTGAAGATATTCCATCACATAAAATGGGATTTTATCATCAGTGAGACCATAGCTTAGAACTTTAATAATATGCTTACTTTTACGTCCTAATTGAGCACCAATAAAAATCTCTCTAGCAAAACGCTGTGACATTTGCTGATTTGCCAAACTTAATGACAAAATCTTCAAAGCAACAGGCAGCCCTCCTTTAGCAGTATCCTCTGCTAAGTAAACCCTACCCATGCCTCCACGACCAATTAATTCTCTAATTAAATAGCGATTGTTTAGAAATTTTCCTATGTAGTCATCTAAATCTATTTTAGCCATCACTAAATTATTAACTGGAGCTTGTAACATAAAAAGATATATATTATTATGCGGAGAAAATCAGATTATTATTTAGTCAGTGATATGTACTATTTTATTTTATCTAGCAAAAACCCATTTATTTTTATAGAGTCAATTAGGTTAAATGAAATTAAGTTTAAATAAACATCAAGCATTTATAAATAGTGGTTAGTAGACCTATGTAAAACCTACTAAACATGGTTTAACATATTTATTTACTAATCTATATGAGAAATTACACGGAAACAGGAAAAACGATTAACTATAGCCACAAATAAAATCAGTGTATTCACTGAAATTGTTTCTAGACTGTTCCCACAAATATTTTGAATAAATGAATGATTCAGAAGAGGCAAAATCCGTCATTGCCTGGTTTAAGCAATCGGAAAAAAGAATGGGACGCATCGTACAGGTGTACCTTGCTTCTACGGTTATGAGTACGGTTGTTCACCCTCATTGATAAGCGCGTAAGTAACCCTAAGTAGGTGGCTATTGAAAATTGTCGTTGTGACAAGGCACTAGGTGTTGCCCTGAGCTTGTCGAAGGGCAGTTGTGGTAAGCGCAAACATTTGGGCTGTGCCTAAGCTGTTGACTGTGATGGAATTTCGACAGTTTTCTTTCATAAAATTTTTGTGTCATTGACTGGTTCCTATGTTCTGCCTGGGAACCCTGACTTTGAGGCTTCGCCTCTTATCTGGAGTGGAGGCAGAGCCAAAGGACATGCATTCCTTGCCGGAGACAAGGAACGAGTTACACAAGGATTTTTGGATAACTTTACTTTCCGTTACATACTACTCCCAGAGAAGCCGCTGCACCGTTATACTTAGCTGCAAACAAATTTTACAGACATAGGAGATTTTATCTTAGTGAGGTACACCTACAGCGGGCAAGACTTCGGCGTGAGCGCTCAGTCCTTAGACAGGCTCAGGAACCATCGAACGCTGCCCGTACCACCACAGCTTCATTCTTCATCTCCGTACCTGATTTACGTGTAATCTACCGGAAACGCGCACAGTGCCCCTAGTTTCTAACTATAGGGGTGTGGTGCGTTTGCGAATTTATTCGCAGTCCTAAAAATCATTTTAGCGAATAGTAGGTTTAGTGTAGAATACAGTCAGGAGGTGATGAAAGTGTTCAACCTGACTTACGAATTTAAGCTCAAGCCAACTCAGAACCAAATAACAATGTTTGAGGAATGGCTGGAAACCCATAGGCGGGTTTACAATCATGCGTTAGCAGAGCGAAAAGACTGGTATAAGTCTCGTAGTTGTCGGGTAAATGCTTGTAGCACCCATAGTTGTTACATTATTCCTGCCGATGTTCCCCGCCCAACTTTTGCGAGTCAATGCAAGTCTTTAACTGCTGCTCGAAAAGAGTCAGAGCATTTGCGACGGGTAAATGCTCAGTCATTGCAGCAGACGCTAAGGCGACTTGAGAAGGCTTTTGTAAGTATGTGGGAACAAAATCATGGGTTCCCAAGATTTAAAAAGTCGGGGCGAATGCGCTCTTTCTCCTTTCCTCAATTGGGTGTAAATCCATTAAGTAATGGGTATGTAAAATTACCCGTTATCGGAGCAGTAAAAGTGCGCCAATCTCGCTCTATCCCTGACGGTGGAGTCATTAAGCAAGCGTGTGTGGTTAAGCGGGTTTCTGGGTGGTACGCAATGTTAACCGTCCAATGGGATGTCAACGTACCTCAACCATTACCTCACGGGGAAGCGGTAGGAATTGATGTTGGTTTAACAAGTTTTGTCGCCACTTCTAGTGGGCTTTTGGTCAAACGTCCGAGGTTTTTTGTAGATGCCGAACGCAAGCTTAAATTGCTGCAACAGCGTGTCTCCAGAAAACGCTTAGGCTCGAACAATTGGAAAAAAGCACAGAAGAAAGTGGCAAAATTGCATGAGTACATTGCTAACTGTCGTAAGGATTGGCATCGAAAGCTGTCTCACAAAATCTGTGACGACGCAGGGATGGTGTTTGTTGAAGATTTGAATCTAATTGGCTTGTCTCGTGGAATATTGGGTAAACATTGCCTTGATGCGGGATTTGGTCAATTTTTCAACATCCTTGAACAAACTTGTTTTAAACGTGATGTCTATTTCCAAAAAGTAGACCCACGAAAAACAAGTCAAATCTGCCCTAACTGTGGAATTGAGACAGGGAAGAAAGAGCTTTCTGAGCGTACTCATGTTTGTTCAAATTGCGGCTATACAACCGATAGAGATGTTGCAGCCGCTCAAGTAGTCGCAATACGCGGACTTGCAGCCGTAGGTCATACGGTCAAGATGCTTGCTGAGGGTAAATTCGTTGGAATCCCTGTGAAGTAAGAATCCCCTCGCCTTTAGGCATGGGGAGTGTCAATGTATTTACTTATTAGAATTGGGAACAAGTTGGCGAAAGAATCTCAAAATGGGTGAAGAAGATTCTGTCTTTAAGCGCAAAGCCAGTATTTGAGTGCGCTGAAGCTTGTTAAAATTATTATCGCTAATCAAGATCAACGAAGGTTGTCCATCTGCTAATTGAGAACCTAATGTTAAACCTTCGATATTATCCAGCAAAACATTCTCTTTTCCCAAGTCTAAAAGTAGTTGCTTGCGAACTGGTTGAATATTTGCAATGTCGGTTGCCAAAAGACTATCAATATTACGAATATCGGTTGCACCTTCTAAGGAAACTTTAAATAATTTGACTGAAAAGCCAAAGCCTGTAAAAGCCCGTTCTAAACTTAGCAAATTACCCTGATTATCTAATGCAACTAAATCAGGTAAACCATTAGCATATTTATTAATAATTTTAATTGTTGCTGGTGCAGCTTCTGTTGGATATAAAAATTCTTTTTCTGCTTGATTAGTAGCAAGATTATATTGCAAAATTCGGCAGGGACTACTAGTATTAGGTTTTGCTTCCGAGCCATCTTGAACTAATGCATTCTCTGTGGCTGTGTAGAGAAACTGATGATCAGGTGTAACAGTCAGACTTTCAAATCCCAAGTTGTTGCGGATACCACGTTTACTAGATGTTGGTAAGAATTTTTCGGGTACGGGTAATGTTTTCACTTCTTTACCAGAAGCTAAAGTAAATTCTTTGATAAATGGGTTAATTGACTTACCCACATCACCCTCAGATGACACATATATGTCACCTTTTTGGGTTAAAGCGATACCTTCTGTATCAGTGGTTGTGGATGCAAAATTTTTACCCTGAGCATCCAAAAGTAAAGTAACACCAACGGGAACAACTCCCCCTTGTTGCAACTTACCTTTGCTTAAATCGATTTTCAATGTATAAAATCTAGCTGGAGCTTTATCTCCACGATCGTCAGATATGGCATAATATACTTGATTGCTGGCATCGTAGGTAATGCCCGATAAACCTCCAACTTGGGTATTCTGAAATAAAGTCCCAGTTTTTAATACTGCTTCTCCAATGAAATCTGCACCAACAATTTCTACAGATGGTGAAGTGAAGTTCGCAAAAAATAAACCAATTAAGATAATTGGTAGGCAAAAGTAAATTATTTTTTTCCAGATATTATTTTTTTTAATTAGTTGCATATTTAAGCTTTGGGATCCTGTTATAGCCACAAATACGATACCACGGTGAACGTAATATTCAAGGTAAAGTAGCTGATGCGTAGTTTACCACCGTAGGTATCGCACTCTCTCTAGAAGTCTTACACTAACTTAAAGATACTGTATATCTGGCGAAATTAAATGGGACGGTTGTATAGTCATTAATCAATATATTCCATACCAACTGTCAAATTTACCTGATGCAGCAAAAAACTATTAGTCAAAAAATATTCAGAATCATCTTAATTGCCCTAGCGACAATTGGAGGACTCGGAATTATTGGTGGTGGGGTATTTCTCTATCTATTAGGCAAAGGCTTTGAAGAGGAAACAAAATCAACCACTAATATTTCTCGCTACAAAGAAATTTTTACCAATTTTGGAGAGAATGCTCCAATTATCAAACATTTTCCCAGAACTATACCTACCGATGCTAAAAATGTTAAATTTTACTTCCAACCTGGATTTTTACAGGGTGGAACAATTATTCGCTTGAAGATGACATTACCTCCAGAAAAAATTAAATCTCTACAAGCAGAATTTAGAAACAAAGCCAAGCGTAAATATATTCCTGGAGATATCAAGAATAGTAGTCCCCAGGAAGAAGTGAGTCCCCAGGGAATACGTGTGAATTTTAAATATGATTTATCTTTAGGAGATGATCAAAATTCCAGCGAGAAAGTAGATAATTTACCCAAAGTTCCATCTAAATATGAAATTTTAGTCATTGATGATACTAGAGGTGCGCCAAAATATGATTGGAATCATTCTGACACATATGGTGTGGCAATTAATATTTCATCCTCGGAAGTGATCTATTTTGCAGATGATTGGTAAATCATCTGCTTTTGAGATTTACCCACTCAAAAGACGTTCCAGTGGAACGTCTTTTGAATATCTACTATATTCGTACTTAGGTTGTTTCCCTTTGTCCCAAAGAAATAGCTTCATCGCGCTTAGAAATAGCCCATACTGCATGGATACTTCCAGGAACCCATCCTAACAAAGTTAATAGTACACTGATGATCAAAGTTTGACCAATTCCATAAGTGAGGAATATACCTAATGGAGGTATGAGAATCGCCAAGATATAACGTAATACTTTCATAATTACCTAATGTGTTTGTGAATGTTGGAAATATAAAGAATAAAGATCCTTAAATTAGTTAGATGGCAAGTTAGTTTTATTGATGCTGCCACCAGAATTCAAAGCCAGATTCTTCTCGACAAAATAATTATTAATGAGGGTATTTGTCAAAGATAGAATTACGGGAGCAGCAATAAATGCAACCAGTCCACGCACTGCAAAGCCCGGAACTACTACAGATGCTAACCAGAAGCAAAAGCCATTTACAACTAGGGAAAAAGCTCCCAGGGTGACAATATTAATTGGTAAAGATAAAGTTGAAAAAATTGGTTTTACAGAACCATTAATCAAGCCCACAACTACAGCCGCAATCATCGCAGCAGGAAAGTTAGCAATACTAACTCCTGGGAAGATGATATCTACAACTAGTAAACTGAGCGCAGTAGCTAGAACTGTTAAAAATACTGATATCATAAGTTATTACCCAACAACGCCAAAATTCTTTTTCTCTTTCTTTTCCTATATTTGACGATATTTGAATCTTTAACCTCTCTATAAAGATAGATCCAGATATCTACATTTTGGCGTATGTTAGAGATGTAGGATAACTCCACAAAAAAGATGATCCAATATTGTGGGATAGGCAGCGTTCGATGCTTCCTGAGCCTGTCGGAACGAAGTTTACCGGAGGTAAGGACTGAGCGCTCACGCCGAAGTCTTGCCTGTTCTTGTATTAGTAGCAGGCAAAATGCCTACAAGAAATTTTGGGATATTTATTTGGAAGTCTCTAGGATTAAATACTGAGTCATATTAGCTACGGAAATATAGTTTATAGGGTTTCCCTAGCAGATGAAGTACACCAATTTTGATGCAAAGCTTATATTTCAAAGTATATAGATTTTAATCTGTACCTCACTAGACTGAGAAACGCTATATAATCTCATTGATCTAGGACTTACCCATTGACAGGTATGGTTTTCAGAGTTAAAAGCTTGTTTTTCTGTTCTCTATCAAGCGATAGTATTAGCTGAATCTCAATTGCAAACAATTGCATATATTTTTATTATCAAGCCCTAAATAACTGTATTAAAAATATATAGATCAATTCTCCGGTGCTAGTAAACAGGTATAACAAATGCTGCAAAATATCCACGAAATCCAAGATATACCTGGAGAAAAATATCGGTTCAATGGGAATGAACCGATTCTCCTGGATGACCCAAGGGCGATTTGGGTTGTGCAGTCTGGTTCCTTTGCGCTGTTTGCTATTAATGTAAAAAATGGCACTCCGGAAGGAACACGGCGTTTTTTGTTTACGGTGAAAGCTGGAGAAGCGATGTTTTCCACTCCCCACGATACGAAGGAGGAGGGAATTAGGCAAATTTTGGCGGTTTCTTTGGAAGAGTCAGAGTTAACGAGGGTTTCAAAAACGGATTTTGAGACATCTTTGGCAAGCCAAAAACGCACCGTGATTAATTTGGTGGAACGTTGGATTCACCAGTTAGGGGAAATCTTAGAAAGTATCCGTACTGAACGTCCCAGTGTCCCCGATGCAGCGATTCAATATATGTCGTTAGCGATGGGGGAAATTTTCCAATCCTATCCCCATACTGTTTGTTGGATTAGGATGCAGGTGGGAAGGTTGCGGTGGATGGGAATTCCTCAGTTAGGGTTGGAACCGGGGGATGAAATTATGCCACTGGGTGCGAATATGTGGGTAATTGCTGAGGAAATTGTTGAATTTGAACGGTTACACACCGATACCATCGATGATGCAGATATACTGTTGGCGGGTGTAGATCAGGTTCAAAATTACTTTTTACGCTGCATAGATTTGTTGGAAGAGGTAGAAAAGCAGCAAGAAAGGCAGCGATTTCAAGAACGCGATCGCTTAAATCGACAAATGATGACGGAGACGTTGGGTGAGCTTGTGGAGGTTGTGCGATCGCAACCAATGCCTGTTACACCTGATTCTACCGCAGAAGTCACCGATAACTACGAAGCGGTACTCATTGCAGCGGGTGCAGTGGGAAAAATGCTAGGGATTAAAATTCGTCCCCCAGCAAAGTCGGAAGATATGCGGAGAGTGCAAGAACCGCTGGATGCGATCGCGCGTGCTTCCCAGATGCGAATGCGTCGTATCCAACTAACTGATGATTGGTGGCAAAAGGATTGTGGTCCTATGCTGGGGTATACGGCGGAAGACGACCGCCCAGTGGCGCTTTTACCCACCTCCAGCACCAGTTATGAGATGTTTGACCCCATCCTCCGCAAACGTCTCAAGCTCACCGCCAAACGCGCCAGAACCCTATCAAAATGCGCCTATGTTTTCTACCGTCCCCTTCCTGATAAGGAAAACCTCACCACCTTCGATTTACTTCAGTTCGCAGTTCGCGGACATTATCGAGAGATATTCGTAGTTTTAGCTACGGGGGTAATTGTGACTTTGTTGGGGATGCTCACACCCCAAGTCACTGCAATCCTGATTGATGATGCAATTCCCAGCACCAACCGCGACTTACTAATTCAAATTGCTGGAGTATTAATTGCTGCCACATTTGGTAGTACCTTATTTCAACTAGCGCAGGGATTAGCGGTGATGCGGTTGGAAACCTACGCAGATGCTTCCACCCAAGCGGCAGTGTGGGATCGGTTACTCAAACTCAAAGCCTCATTTTTCCGCAAATATGCCATTGGTGACTTACAAAGTCGTGTCCAATCCATTAGTCAAATTCGGCAAATGCTGGGAACAACGGTAATTAAATCGATATTTTCCAGCGTTTTTTCCCTACTAAATCTCGGCTTACTATTTTACTACAGTCCCACCCTTGCCTTTGTGGCTCTCCTCGTTGCCTTCATCAACATTGCTGTCACCGTGGTTTCCGGGATAATTACCCTGAAAAAAGTACGTCCCCAACTGGAACTCCAAGGACAAATTTTTGGGGTGATGGTGCAATTAATTAACGGTGTCACCAAACTCAGAGTAGCAGGTGCCGAAGCTCGTGCCTTTGCCTATTGGGGGAAACAATACACCCAACAACTCAAATTAACTTTGAGTACCCAAGGTGTGGAAGATATAGTGATTGTAATTAACAAAATTCTTCCTTCCTTAACCACCGCTGTCCTGTTTTTCGTTGCCACCACCTCCATCCAAGAAGCCGCAGCTACGGGGGGTAAAGGCTTCACCACCGGGACATTCCTGGCTTTCAATGCGGCATTTGGGATATTTATTGGAGGTGCCACCAGCCTCAGCACCACCGTAATTGATGTTCTCCAAATTGTTCCCCTGTGGCAACGTGCACAACCCATCCTCAAAGCTGAACCAGAAGTAGATAGCAATAAAGCTGATCCGGGAAGGTTGACGGGGAGATTAAATGTGGAACATGCCATTTTCCGCTACCGTGATGATGGTCCTCTCACCTTGGATGATGTCTCCGTTTATGCCAACCCAGGGGAATTTATTGCTTTTGTGGGGACATCGGGAAGCGGTAAATCAACCCTGTTTCGGTTGTTATTGGGTTTTGATGTGCCAGAATCAGGTAGTATCTATTACGACGGTCAAGATTTGGCAGGTTTAGATATCAACGCCGTGAGAAGGCAACTAGGAGTCGTGATGCAAAATAGCCGTCTCACCTCTGCATCAATTTATGAAAATATCGCCTGTGGTGCCTTGGTGTCAATGGAAGAATGCTGGGAAGCAGCCAAGATGGCAGGTTTTGCTGAAGATGTCCAGTCAATGCCCATGCAGATGCATACTGTAATTAGTGAAGGTGGTGGGAATATTTCTGGAGGACAACGGCAACGGTTACTAATAGCTAGGGCATTGGTACTGAAACCACGTATACTATTATTCGACGAAGCCACCAGCGCCTTAGATAACCGTACCCAGGCAATCGTCAGTGAAAGCTTAGAGAGACTGCAAGTTACCAGAATAGCGATCGCGCATCGTCTCAGCACCATACGCAAAGCGGATCGCATCTATGTATTTGAAAATGGTAGAATTACCCAACATGGAAGTTTTGAAGAGTTGGCACAGCAGAAAGGGTTATTTGCTCAACTCATGGCAAGGCAAAGTTTGTAAGTGTTTGTCCAATATAGTAGTCATGATTTTCTGCTAAGTCAGGAATATCTACACTAATAGAACCAATTAATTTTAAAAGTGGATCTTTCTCCACTCGTCGCTCTTCCAACATTGCAGCTACTTCTTCATCCGTCGGTGCTGGCTGATCTGTTTTTAACAAACCGCGCATTCGACGGATTGCATCAGAGCGATTAGGTTGGGGGATTAGATCATTTTGTAAAGACTCAATAATGGCATCGCTTGGTGGTAACTTAAAAACTTGCTCCTGCAATTCTTGTAGCAACATAAAGGTTTTTCTGATATTTTACCGCGCATCCTCATTCTACAAATATAGCGAACGACTTACGTCGCGCAAGCTTCGCTACGGTGGTAAACTACGCGTAACCTGACGAATGCTAGTCACAAAGCAACATCAACCTGGTTTAGCATTGCTAAACCCCTACAAAGTGGTCTATTTCTCTGAAAGTAGCTTTAACATCTCGCACAATTCTTCCTTTTTATCTTTGGTATGTTGAACGCTAAGTAAAGTCGTCAACACTCCACCTGATGCTGTGAGACTAGCTTCAGACACTTTGTCAAAGTATAAAAGTCCAACACCAAAGAGAGTAATCAAGGCAGATGCAGCAGTAATACTTAACGCGAGGTTGTAGCTTTTACGTGTCATTCGCAATAATTCGCGGATAATTTCTTGTTTGATATCGCTGTAGTCGTCGTTATTTTGGGGTTTGAAAAAATTAAATTGCATGGTGATTCTCCGAAATGCTGTGTTGTTTGTTCGTGATATTGGTATCCTACTCAGACTAAAAAATACATGCCAGGGCAAATGGGTTTTGTTTGTATTGAGTGTTTGCCCTATTGCTGTGTGGTAATTTAGGGCAGATAGGGAAGTAAAGAAAATCTATTTGCCCTAGTTCGGGAAACAACTAATTCGCTATTGTTTATATACAAGTATCAATACTCCGTTACGGCAATGCGTGAATCTGATAAAGTGCGATCGAGTGAGTCAGGTAAAGCCAGACTCAAGCAAGCTTATAAAGAAGCTGGATTAAAACAAGATGAGTTAGCACGGCAGGCAATAGTGTCGGTTGATACTCTTAAGCGCCTACTTGGTACTAAGGATTGTCCAAACGGGGTTGAAAGACAGGCTGTTAAGAATATTGCAAAAATTCTGAAAATTAAACCTACAGATATAGTTGATGTTAAAGACTGGTATCCTCAACAGCAGTTACCAGCAGAGTTTGAACGACTAATTTACGAAAAAACACAATTATTTTGCGGACGAAAATTTGTATTTGATTCGATTGAGGATTTCTTCCAAAATAACCCAAATGGCTATTTCACTATTATTGGTGATGCGGGGATGGGGAAAAGTGCCATTTCTGCAAAATATGTATTAGATAATCCAGAAACTATTTGCTTTTTTAATATTCGTGCCGAGGGAACTAATCGTCCTGAATTATTTTTGAAGAAAATTCGCCAACAGTTAATTGCTCGTTTTCAATTACCAGATGTCGCTGATGCGGATTTATCAACTTTATTGACTAAAGCGAAGGAAAAGTTATCCACTGGAGAAAGATTAATTATTGTTGTTGACGCGCTGGATGAAGTTGACCAGGAAGGCACAGCAAATATATTATATTTACCAACAATTCTCCCCGACGGTGTTTACTTTATCCTCACCAGAAGACCCTATAATCAAAATGAAAAAAGGCTGAATCTTTCCCCCAGTATCCCGACTCAAGAGTTGGATTTGAGAGAGAAAATCCAAGAAAGTGTGCAGGATGTCAAGGAGTATATTCGAGAATTATTAAGCGATGGCAAATATCAGCAGGGTTTAGCGGAATGGATTCAACAGCAAAATCATATTTCCCATGAGGATTTTGTTGAGACAATTGCGGTGAAAAGTGAAAATAACTTTATGTATTTGCGGTGTATTTTACCAGCCATCGCTGAAGGTTATTACAAAGATAAGCCTTTGAATGAATTGCCTGTGGGTTTAGAAGGATATTATGAAAACCACTGGCATATTATGGGGATGACAGCTAAACCTTTGCCGAAAAATAAAATCAAAATTGTTTATGTCATGTGTGCTTTACGTAGTGCTGCTTCTCGTGAGGTGATTGCTAAATATTCCAAGCAGAATGCATTGACTGTGCAAGAAGTTCTGGATGGATGGGCACAATTTTTACAGAAACAGGAAAGCTATCAACCACCACGTTATCGATTTTATCACGAGAGTTTTCGAGAATTTTTGCACCGTCGGGATATTGTCCAAGCTGTGGGGGTAAATTTACCAGATATTGGCGCTGAGGTTGCCAATAATATGACCGAGGGGCTGATTTTATGAGTAATCTTCGCGCTTGGTTGGCAGAAAAAACATCGGAAGAAATCGAACATTTTTTGGGTGAAAGCCCGCGTTTATTGTTAGATGGTGGGGATATCCATAAATATTGTGATTTATTGAGTAATTACGATTTTATTGAAGCGAAAATCCATCATTGTTACTTTGGCATCCAAACACTGATTGAAGACTATAAATTAATTGATAATACCGAATATGCAAATCATCCAGAGTGTAATTTTGAAGCAATAGAATCCCTCAGGATTATTTCCAATGCTTTATTTCGCTCTTTTCCCGTCATCACTGATGATAAAACTCAATTAGCTGGGCAATTATCAGGACGTTTGTGTTATTTTCAAGAACAAGATTTAATCAAAAAATTATTAGAGCAAATATCGCAAACTAATAAGACTTGCTTCCGTTGTCTCACAGGTTCTCTCACACCTCCTGGTGGAAGTCCTTTAATTCGCACCCTTACTGGTCATAGTGATGGGGTAAGTGCGATCGCCACCAGCAATGATGGGAAATATGTGGTTTCTGGTTCAGATGACGACAAAACAGTAAAAATCTGGGAACTGTCCACAGGAAAGGAAATTCGCACCCTTTCTGGTCATAGTGATGGGGTAAGTGCGATCGCCACCAGCAATGATGGGAAATATGTGGTTTCTGGTTCAGATGACAAAACAGTAAAAATCTGGGAACTGTCCACAGGAAAGGAAATTCGCACCCTTTCTGGTCATAGTAGTAGGGTAAATGCGATCGCCACCAGCAATGATGGGAAATATGTGGTTTCTGGTTCAGATGACAAAACAGTCAAAATCTGGGAATTGTCCGCAGGAAAGGAAATTCGCACCCTTTCTGGTCATAGTAGTAGGGTAAATGCGATCGCCACCAGCAATGATGGGAAATATGTAGTTTCTGGTTCAGATGACAAAACAGTCAAAATCTGGGAACTGTCCACAGGGAAGGAAATTCGTACCCTTTCTGGTCATAGTGATTGGGTTAATGCAATCGCCATCAGCAATGATGGGAAATATGTAGTTTCTGGTTCTAGGGACAAAACAGTCAAAATCTGGGAATTTTCCACAGGTAATTTTATTCGCACCCTGACTGGTCATAGTGATTGGGTTAGTGCGATCGCCCTCAGCAGCGATGGGAAATATGTAGTTTCTGGTTCTGGGGACAAAACAGTCAAAATCTGGGAATTGTCCGCAGGAAAGGCAATTTGCACCCTGACTGGTCATAGTGATTGGGTTAGTGCGCTTGCCCTCAGCAGGGATAGGAAATACATAGTTTCTGGTTCTGTTGACAAAACAGTCAAAATCTGGGAATTGTCCGCAGGAAAGGAAATTCGCACCCTTTCTGGTCATAGTAGTAGGGTAAATGCGATCGCCACCAGCAATGATGGGAAATATGTAGTTTCTGGTTCAGATGACAAAACAGTCAAAATCTGGGAACTGTCCACAGGGAAGGAAATTCGTACCCTTTCTGGTCATAGTGATTGGGTTAATGCAATCGCCACCAGCAATGATGGGAAATATGTAGTTTCTGGTTCTAGGGACAAAACAGTCAAAATTTGGGAATTTTCCACAGGTAATGTTATTCGCACCCTGACTGGTCATAGTAGTAGGGTAAATGCGATCGCCCTCAGCAGCGATGGGAAATATGTAGTTTCTGGTTCTACGGATAAAACAGTCAAAATCTGGGAATTTTCCACAGGTAATGTTATTCGCACCCTGACTGGTCATAGTGATTGGGTTAGTGCGATCGCCCTCAGCAGCGATGGGAAATATGTAGTTTCTGGTTCTACGGATAAAACAGTCAAAATCTGGGAATTTTCCACAGGTAATGTTATTCGCACCCTGACTGGTCATAGTAGTGATGTTCGTTCGATCGCCCTGAGCAATGATGGTAGATATGTGGTTTCTGGTTCTTCGGACAATACAGTCAAAATCTGGGAATTAAGAACAGGAGAAGAAATTCGCACCCTGACTGGTCATAGTAGTTGGGTTAATGCGATCGCACTCAGCAGCGATGGAAAATATGTAGTTTCTGGTTCCTGGGATAATACAGTCAAAATCTGGGAATTAAGAACAAGGAAGGAAATTCGCACCCTGACTGGTCATAGTAATGGGGTTAGTGCGATCGCACTCAGCAGCGATGGTAAATATGTCGTTTCTGGTTCTGGGGACAATACAGTCAAAATCTGGGAATTAAGAACAAGGAAGGAAATTTGTACCCTGACTGGTCATAGTGATTGGGTTAGTGCGATCGCCACCAGCAGCGATGGGAAATATGTGGTTTCTGGTTCTTCGGACAAAACAGTCAAAATCTGGGATTTCTACACAGGTAATGTTATTCGCACCCTGACTGGTCATAGTGATTCGGTTTATGCAGTTGCCCTGAGCAGGGATGGTAAATATGTGGTTTCTGGTTCTAGGGACAAAAAACTCAAAATCTGGGAATTAGGAACAGGTAAGCAAGTTTGCACCCTGGCTGGTCATAGTGATTCAGTTATGGCGATCACCCTGAGCAGGGATGGTAAATATGTGGTTTCTGGTTCTAGGGACAAAAAACTCAAAATCTGGGAATTAGGAACAGGTAAGGAAATTCGCACTCTGACTGGTCATAGTCATTGGGTTAGTGCGCTTGCCCTGAGGAATGATGGGAAATATGTGGTTTCTGGTTCTAGGGACAATACAGTCAAAATCTGGGAATTAGAAACTATAAACAAAAGATTTTTCAACTTTATTTGGAATTGGATAAAACTAAGAAAGGAAATTCGCACCCTGACTGGTCATAGTGATTCGGTTAGTGCGATCGCACTCAGCAGCGATGGTAAATATGTCGTTTCTGGTTCTGCTGACAATACAGTCAAAATTTGGGAATTTTCAACAGGAAAGGAAATTCGCACCCTCAGTGGTCATAGTGATTCGGTAAATGCGATCGCCACCAGCAGCGATGGGAAATATGTGGTTTCTGGTTCTTCGGACAAAACAGTCAAAATCTGGCATTTCTACACAGGAAAGGAAATTGCCACATTTACCGGAGAAGGTAGTATCGGTTGCTGTGCTATTACCCCCGATGGTACAACAATTATCGCAGGTGATGCATCGGGAAAGGTGCATTTCCTCAAATTAGAAAATATTGAGGTACAGTCATGAACACCCCACCTCAATTAGATTTCCAATTTCAAAAAATAATATTAGAAAAAAGCCATAATTTTACTAACTGCGAATTTATTTTTACTGCAATTAATGATTTTCTCCACAAATATAACCGGGGTTATTTCACCATCATTGGTTCTCCCGGTAGCGGTAAAAGTGCTATTCTGGCTCAATTTGCTAGTTTCAATCCCCATTCAAATATCAATATTATTTATTACAACGCTCAAATAGAAAATAAAAATATTGCTGAAGAATTTCTCAAATATGTTTGTAGTCAATTAATTGAAAAGTTCCATAATTCCTTGATTACCCCACCCCAACCCTCCCCGCTAGCGGGGAGGGAGCAAGATTCTAACTTCCTTCCGTATAAAGAGAAACAGAGAGGGCAAGATTCTAACTTCCCCCCGTACACGGGGGGACAGAGGGGGGTTCTTCCCGATAATGCAACGGAGGGAAGTTGGTTTTTGTCCTTATTACTCCAACAAATTAGCGACGAACTCGCACCCAACCAAAAGCTAATAATCGCCATTGACGCACTAGATACAATTAACCCCAACAACCAACCACCAGGAACAAACCTGTTATATCTTCCCCGATATCTTCCCCCAGGTATTTATTTTCTCCTCACCCGTCGTCCCTTCAAAACCGAAAAATCCGGTTTACTCATCGAAGCACCATCGCAAATTCTCGATTTATCCCAACATGACTTAAAAAACTGGGATGATGAACAAGCATTTACCCAACATTGGCAGCAAATGCAAGGTGAGGGTTTCTCAGATATTGCTATGAAAATATTGCAGGTTCTCGCAACTCCCGAAAATGAAGGTATATCAGCAAGTACAATACTTCAAAGGATTCACCAGACAAATCCACCAACTCTTGATGCAGATATATTTGATGTGGAAGAAGTTTTGGAAAATTGGTTTGAGTTTTTACAACAGCATCAAGTAAATAAAGAAATCCGATACAGTTTGTATCATCCTAACTTTCGTAATTGGTTAGCAGAAAAATTGAGTTAAACCTTGTCTGCTTGGAGAATTGTAGTTTTAATTGCCAAGACTCAATGATGGCATTTCCCAGCGCTAGGCGTAGTTTACCACCGTAGGCGATCGCTTAAAATTTGTATGTTAGATCTTGAGTGCGATCGCTTATTACGTCCCGCAAGCTTCGCTTAAAACTCTAAACGTTACTTTCTAACCTCAGATGATCGTTCCAGTAGCTCATTAATACTGCTTGTATAATAGACGGGAACAGTAGAGTGGTGTTAGCAATGTGCGGAATCGTAGGATATATCGGGACTCAAGCAGCGACGGAAATATTATTAGCTGGACTAGAAAAGCTGGAATACCGGGGTTATGACTCCGCAGGTATTGCCACAATTTGGGAAGGTGAAGTTAATTGTGTTCGGGCTAAAGGAAAATTAGTTAATCTCCGTTCTAAGTTGGAACAGGTAGATTCCCCAGCACCAATTGGTATCGGACATACTCGGTGGGCAACCCACGGGAAACCGGAGGAACATAATGCCCATCCCCATATGGATACAACTAATCGTATCGCAGTTGTCCAAAATGGGATTATTGAAAATTACCGGGAACTGCGCGAACAATTAAAGAGTTCGGGAGTTGAGTTTCGTTCGGAAACCGATACCGAAGTCATCCCCCATTTAATTTCTCAGTTTTTCCTCGAAGAAATCGCCGTCTCTGAAGATACTAATTCTGCTACTTCGCCATTTTTTGTCGCAGTCCTGAAGACTGTAAATCAACTGGAAGGTGCATTTGCCATTGCCGCAATTTCCGCAGACTGCCCTGATGAATTAATTGTAGTTCGTCAGCAGGCACCTTTAGTTATTGGTTTTGGGCAGGGTGAATTTTTCTGTGCTTCCGATACACCTGCTATTGTTGCTTACACCCGTGCTGTATTACCTCTGGAAAATGGCGAAATCGCCCGTCTCACACCACTAGGGGTAGAAGTTTACGACTTTTCTGGTAGAAGGTTGAAAAAACAACCTAGATTATTGAATTTGAGTCCCACCATGGTGGAAAAACAGGGATTCAAACACTTTATGCTCAAAGAAATCTATGAGCAACCAGAAGTTGTCCGTGCTAGCCTGAATGCTTATTTTAATCTTGATTGGAAAGCTGAAACAAACCAAGATTCTCCCATCAATCTTGGTATTCCTGCCGAACTTTACGCAGATTTAGAACAAATTCAAATAGTTGCCTGCGGTACGAGTTGGCACGCGGCACTTGTGGGTAAATACTTACTGGAACAGTTAGCAGATATCCCTACTCAAGTTCAATATGCCTCTGAATTTCGTTACTCACCTGCCCCTGTAACAGCCAACACCATTACTATTGGGGTGACTCAATCAGGGGAGACAGCCGACACCATCGCCGCCCTAGCAATGGAAAATGATCGCCGCCAAGGTCGAGAAAGTAAGTATCAAGCGAAACTACTAGGTATTACCAATCGTCCCGAAAGCAGTTTGGGACATATGGTACCCCACATCATTAATACTCTGGCGGGAATTGAAATTGGTGTTGCTGCAACCAAAACATTTATTGCTCAATTAATGGCATTTTATGCTTTGGCGTTAGATTTGGGCTATCGTCGCCAAAGTATCCCAGGGGAATTGATGGAGGAGATTCTAGAAGGATTGCGACAAATCCCGGCAGAAATTGAATCTACCTTGGAACAGCAAGAAAAACTCACCGAACATTTAGCCCATGAATTCGCCGAAACCCAAGATTTCATCTTTTTGGGTAGGGGAATCAACTTCCCCATTGCCTTAGAAGGGGCTTTGAAATTAAAGGAAATCAGCTATATTCACGCTGAGGGATACCCAGCAGGGGAAATGAAACACGGACCCATCGCCTTACTAGATGCTAAGGTTCCAGTGGTGGCGATCGCAATGCCGGGAAGTGTCTATGAAAAGGTGATTTCTAATTCTCAAGAAGCCAAAGCTAGAGATTCTCGGTTAATTGGTGTCACACCTATTACAGATGGGGAAGCTGGAGAAATTTTTAATGATTTGCTGCCTGTGGCGAATGTTGATGAGTTATTATCACCAATTCTCACGGTGATTCCACTGCAACTATTGGCGTATCATATCGCTGCTAGACGTGGTTTGGATGTGGATCAGCCAAGAAACTTGGCAAAAAGTGTTACAGTTGAATAGCGTACAAATACTGAGATAGTTGGCATAGAACCTTTGTTTATCGTTCTTTTAAATTATCTCAATATCTTATTATACTAATTTTTGCTGTGAAATCAATTTGATTCTTGATCACAGTAAGCGATCGCACTTCCAAAAGAAATGCGATCGCTTTGACTATTGACTAGGTTGCATTCACAGCGAAGGATTAAATTCCACAATTAATCGAATTCGACGGGATTGCGCGGAGCGCTTTGAGAAGTCGGCGAGATTAGAAGCGATAATAAAAGATAATTTATGCGGTTTGGGTTATGGCGGATAAATTATCACTAATGGATAGCTATGATGAATTTTTGCGGGAGTTAAAAGAACGTATACGCAGCGCTCAAATCAAAGCAGCTTTATCTGTTAACCGTGAGTTAGTGTTACTTTATTGGCAAATTGGACGCGAAATTATCATCAGACAGCAACAGCAGGGATGGGGTGCAAAAGTTATTGAACGTCTCGCTCAAGATTTAAAAGCAGCTTTCCCAGATATGAAAGGATTCTCCGCCCGGAATCTTAAGTATATGCGAGCTTTTACTGAGGCTTACCCAGATGAGCAAATTGTGCAACAGGTTGTTGCACTAATTCCTTGGGGACATAATGTCCGTATTTTGGATGCTGTCAAAGACTTTTCAGTTAGACTCTGGTATGTCCAAAAAACTATAGAAAATGGCTGGAGTCGAAATATATTAGTGCATCAGATGGAAAGTGGGTTATATCACCGTCAAGGCAAGGCGACTACTAATTTTGAAAATACCTTACCAAAACCACAATCTGAACTAGCGCAACAATTATTAAAAGACCCCTATAATTTTGATTTTCTCAGTTTAGGAAAAGAAGCGCAAGAACGCGATTTAGAAAAGGCTTTAATAGAACATATTCGTGATTTTTTATTAGAATTAGGGGTTGGTTTTGCCTTTGTTGGCAGCCAATATCACTTGGAAGTTGGAAACCAAGATTTTTATATAGATTTATTGTTTTATCATTTACATTTACGCTGTTATGTGGTGATTGATTTAAAAATTGAAGACTTTAAACCTGAGTTTTCCGGAAAAATGAGTTTTTACGTTTCGGCTGTCGATGATTTATTACGTCATCCAGATGATAAACCAACAATTGGCATGATTTTATGTAAGACGAAGAATCAAACAATTGTAGAATATGCTCTGCGGGAAATGAATAAACCAATTGGAGTTTCAACTTATCAGCTACGGGATATTTTACCGGAACAATTGCAAGGAAGTTTACCCACAATTAAGCAATTGGAGGCAGAACTGGAGGCTTTATCTGTGGATGTTGAGGATGAAGAATGATAACTATGTTTTCATGCCTAATCGATAAACCTATGCAAGGACATGGATTAATGCAAGCTTGGCACTAATTGAGAAAATTATCTTGATTTCCACCATTGTGACCAATTTTGAATCATATTATTAGCGCTATTCCACAGTTCTTCGATCCTTAACTTCCTGTGCTTTCGTCTCAGGGTCAAATTTTAACTGCGGATTCCACTTCTGTGCTTGCTGGAATTTAGTCACCGCAGCCTCAGCATCCCCATTTCTCGCTAGTTCTTCCCCTTGAACCACCAACATCTCAGCAGCCCTAGCTAAAACAGATGGACTTTGGCATGACTTTAAATCGCCTAAAACTTCAGCACGGAAAGGTAAATAGTTATCTAAACGACTACAAGCACTTTTAACTAAATTATTAAAATCTAAATCCCATAAAATGACTTTTTTGTCGTCACTAGCAGAAGCGAGGGTTTTGCCGTCGGCACTCCATGCCACACCATAGACGTGATCGCTATGCCCATTCAGGGTTTTGAGTGGTTTACCCGTGGTTGCATCCCAGAGTTTGATGGTATTATCCCAACTAGCAGAAGCGAGGGTTTTGCCGTCGGCACTCCATGCCACACCATAGACCGCATCGCTATGCCCAGCAAGGGTTTTGAGTGGTTTACCCATGGTTGCATCCCAGAGTTTGATGGTATTGTCCAAACTAGCAGAAGCGAGGGTTTTGCCGTCGGCACTCCATGCCACACTTATGACCCCATCGCTATGCCCAGTGAGGGTTTTGAGTGGTTTACCCGTGGTTTCATCCCAGAGTTTGATGGTTGTGTCCGAACTAGCAGAAGCGAGGGTTTTGCCGTCGGCACTCCATGCCACACCATTGACCGCAGAGCTATGCCCAGTTAGGGTTTTTAGTAGTTTACCCGTGGTTGCATCCCAGAGTTTGATGGTTGTGTCCGAACTAGCAGAAGCGAGGGTTTTGCCGTCGGCATTCCATACCACACCTCTGACCCTATCGCTATGCCCAGTTAGGGTTTTGAGTGGTTTAATCGTGGTTGCATCCCAGATTTTGATGGTTTTGTCGCCACTAGCAGAAGCGAGGGTTTTGCCGTCGGCACTCCATGCCACACCATTGACCGCATCGCTATGCCCAATCAGGGTTGTGCGTTCAGTAAATGGATAATTTGAATGTACAGCTTCTCGTAATGCTGCTGTCGTCTGCATCTGGTTGGCTGTTGTGACCCCTTTTCCTTGTTTTAGGGTTCCTGCTACTTTTAAAGCTGCAATTGAAGCATCACGAGTTTCCCCAGAATTAAAAAGTGCATCGGAAGAATTTAGCTGTGCTTCCACTGCGTTAACATCAGCTTGTTGTCTTTGCTCATCAGCTTGTTGTTTTTGCTTATTTGCTTCCCATGCTTGATAACCTGCCGTTACAGACAATAAAGCCAGACCAAATCCCGCAACTATTGAACCAGTCAAAGCACGTTTGAGAAATTTATTTAACTTGGTTTCGCTGATTTTCCTTTGTTCCCTTTCCTTCTCCAATTCATCCATCAACACCTTTAATTTTGGTTCCTGTTGCTGACGAATAAACACAGCAATATAATCATGAACCAATTGATAACGGTCATCAGTTTTTTCTGGCAACAACAACACCAACCCAGATTTAACTAAAATCTCTACAACTAAATTTAATTGGTGAATATCTAATCCATGAGAACTATTAACCAATTCCTCTAAATCTCGCTCTAATTCCGCACGAGTTTTCAACGGACGAGTTCCTTTATCATCCGTCAGGGAATACAACAAAAATTCTGCCACCTGCATATTTTCTGTACCGCAGTTTTTCACAACTGCTTGCAAGTAGCGCTTAACTAATTCTTCCTTGGCTTTCTCACCACTTTGATTACCTAATAAATCATATTTCGCCAAAGTATTAATATTCTCAGCTTGCAATTGTGCCCCCACAATTTGCAACTCAATTGGACGCACTTCTCCCCAGGAACCCGCTAAATCCTCCACCAATTTATCAACTAAAGCAGCTTCCAAAGGAAAATTTGCACCCTCAGTTAAACGCTGAATAATTGATTTGGCATCGTCAGGTTTAAAATTTCCCAATTCATACAAAACATTACTGCTGAGAATATCATTACCAATAATATTCATACTTGATAATTTGTTGCATTCCAACAAATAATGCAAATAATCCACCCGCAACGACAAAATTACCTTTACCGAAAGAAGATTGAGATAATCAGCCAAAAATCCAAAAAATTCTAGCCTTTGTTCTGGTTCCGTGCAAACAAAGAAAAATTCCTCAAACTGGTCAAAAATTAAAACCGTGCGAATATTACGCTGTTCAATTTCTGTTAATTTCTCAAATATCGTAGAACCTAACCCTTCAAATCCAATTTGTTTTGCTAATTCTTCCTGCCAATTCGTGTAAACTCGCATTACCACAGGTAAATTATCTTTAATCCCAATCGCTTTATTTTTCAAAGCTGGCTCAAGTCCCGCATTTACCAGCGAACTCTTACCCACACCCGACTGTCCATAAATTACCGTTAACTTATGCTGAGTATCACCAACACGTTCAACTAATCTTTCTACATCCAATTGACGAGTAGATGCAGCTATTTCCGGCGCGACTTTTTCGCTATATTTATTATGTTGAATATTTCTCTGATTTTCTGTACTAAAACCATCACCTTTAAATGACTGCAATCTTCCCGCACCAATAAAAGCCCGTAAACCAAATTGCTGTTCGACAGAAAATTGCTCTTGTTTAATATCATAAGCTTTGAGATATTCTTTCTGCTCAAAATACAGTTTTTGTAAATAGTTTAATATATCTAGATAAAGTCTTACGTCTGCTAGAGGTTTGCTTAGTTCCCTCGCTGTTTCTAAATTGCTAATTGCTTCTGATTTCTCACCTAAATAATATTGAGACTTAGCTAAAATACATAGATATAGACCTCTCTCCAAACCTCTCTCCTGCGAGGAGAGAGGCTTTAAATTTTCCCTCATTCCCATGCTCTGCGTGGGAACGGATTCACCGAGGCTCTGCCTCGATTCTCTAACAAGAGGCAGAGCCTCTGAGAAAGTCATTTCCAGGCTGGAGCCTGGAAACGAGGATACTGGGGAGCCTGTTGTCAAAGAAGTATTTTCTTGCCCCTCTCCACGTCGGAGAGGGGTTGGGGAGAGGTGTTTTATTAAATCCAATGCTTGCCGAACATAACTATTAGCATCTCGCCAATTTTCTTCACCCAAAGCAGCTTCAGCTAAAAATCCATAATCTCTCGCCAAATCTAGCGGTTTATTTTCTGCGCGATGCGTTTCTAATAATTGAGTAAATATCTTTTTTAAAACATTCCATTCCTGTAAATTTCGCAGGATTTCGCCAAATATAACGCTATCATGATTAATTAAATCTAGTCTTTGATTATTCTCAATCAAACCTAAATATTCTTGAATGTAATTCTTCGTAGCTTGCCAGTCAAGATGATTCTTATCTGTATGTTTAATAGCTTTTAAATAATAGCAAATACAAATTTCTCCAAGAATCTTTACTTGACGTTCTAATTTGTTTCCATTATGTAAGTTACTTTCATTTGATTCATCTGCTAATTTGTTTTCTACACGATCAACTTGTCTCCACAAACTTAAAGCTTTTTGATAATGTTCCAGTGCTGTATCTTTTTGATTAATATTTTTATTAACAAAACCCAACAAGCATTCTAAATCAGCTTCTAATTCCCAATCTAAAATTTGAGAACTGGAAAAATCTTTATCACCTAATAAATCTCTTTGCGCTGCTTCTAATTCTAATTTTAATATTAAATAATCATCTACCAAATAATCATCTTCACCCAATCTCAAATTATTGCTAAACCATAAATTAGCAATATCCCGAAAATGATTTCCTAACTCATCCTGCTGAATTACAAAATTTTTACTAGTTGCCCAACTTTCAAAATCTGGGGCAAACTGCATTAATTGCTTGTAAACATCATCATTAATCCACAACACCAATGGAAACGGAAAATGCTTGCGAAAATCCTCCCGTACCTGATTTACTGCCGTCAACATCTGTGGAAGTCCTTCCACCCTATCCAAACCCAAAACCATCAATGCAGCAGGTAAATCCTCACCAAATTCCTCCCCAATCGCAGCAAACAGAGTTCTCCCCGACTCCCGCAACTGCAACACACTAATTTCTACCGGACAGATTTCTATTAACCTGGATATAATACGCGATCGCAAACTCGCATAATTACACCTTGCCAAAATCAGCTTAAACTTACCCGCAGAGTTTTCAATAGCCCAAGCGAGTTGCTGTAAAGCTTTTTCATTATTTACTTCTAATGAGGTTTCCCGCTGTTCTTCCTGCATAGGATTTTGGATTTTGATAGTTTTTTTAGTAGTCCTCTTTTTAGAGAACTTGGGTTGTTAGAGAGGAAATTATACCCTTTCCGACTCCGATGAAGTACAAAAGAACCCCTCCCCAACCCTCCCCGCTAGCGGGGCTACGGTGTACACACAAGTCTTTTAGAGTTGTCTCCCAGGTTTTTCGATCCCCCAACCCCCTTAAAAAGGGGGCAAATGTCTCTCAAAGTCCCCCTTGAAAAGGGGGATTTAGGGGGATCTACGACGATTTTGATTTTGAACAGAGATGTGTGTACACCGTAGGCTAGCGGGGAGGGTGCCCGATAGGGCGGGTGGGGTGTATTCTGATGTGATTGGGAAACGCTATAAATTCCCTGTTTCCAGAAATATTCTTCAAATTTGCAAAATGCGATCGCATTTTGCACCCTACTGTAATTCCCGCGCTTCTGCCAAAATCGGGTTAACATCAAACCAAAATTCCCCATTATCCCGATATTCAAACACGAACCGACTGCGAATCAACTTTTGATACCCCATATCATCGCTAACTTTTTTCTTTTCCTTCACCCGATGTAATAATTCCCACTCCTCATCGGAAATTGGTAGCACCATTTCATTGCGACGACCAACAATCACGGTTTCCAAAGTCCCACGGGTAAGGGGAAGTGTCATCTCCTCCTGAATGCAGGTATTTAGTAGCTTCAGTAAATCCCGCACATGACCCCCACTTGCGATACACAAACGATCTAAGGTCATTTCGTTATCAAATATTTCCGAAATTTTACTTAATCTATCCACTGAATTCAAGTCAGGAAATGCCCTTGCCATAACCATATCCCGCATCAAAGCCATTCCTTGTTCGTGGATGCTCCCATCTGGCAATTTTACCGGAACCATCGGTAACACCTTCGGGTCATCAAAACGCTGTGTCAACATTCCATAATCGTTGGAAAACTTTAGCGACAGTGGCATTGTATAGACAACATGACAACTTAACTTGTTGAGGGATTCAGCCTGATCGACAAATAAATATTCCTGTTGGGTTCTTCCCCAAGGTTTGACTCGATTATCAATGCGATCGAGATTATCGACAATTACCACCAAACCCTTTTTTCCCTGCTGTTTGAGTTGGATAATGGCAGGTTCCAAAAGTTCTTGATTAATAGCAGCTAACAATTTAACTTTTTGTGGTGCTAAATACTGGTTCAACCTTTCCCGCAATGTTGAATCACTTTTTGCCTTACTGGTAATTTCCCCAATCCCCAGAGACAGGGAATATTTTTCCTTTTCTGCCGAAAATCCCACATCACCCACATGGGGAACCTTCAACTTTACCCCCGTAACCTCCGAGTTTAAGACATTCCAAGCACCTTGAAGTAACTCTTTCAGCTTACGAGGTTCAGCAATATTTATTTTCTCCAAACTTTGACTAACACGACGTGCGATCGCAAGTAAAACATCACCAATATCCACATCGGTCATTTCTAAGTCTTCACTGGATTCAAAATAAATCACATGAAAACCATCTTTCTCCAATTCTACGAGCAAACGTAATAATTCCGTCGATTTCCCACAACCAATATGTCCGGTAAATAGTTGACAAGTAGGATCATTCGGCTTGAAATAGGTAATTTTTTGCTTCAACTTGGTGATCACATCCCCACCCCGCACCGAAGAAAAATCAATATAATATTTTCTATCTTCTGGCTGATTGACAACTAGAGTTTTACTAGGGTCAGTTGCTTCAAAAAATCTGCGTAAATCTATAGCCATTATGCTGCTGATTTAGTAAGTATTTATATCCTTTACGCCTTATGTGAGTTATGAATAGGATTGAACAGGAGTCTGCTCAAAGGTGAGAACATCAATGCCAAATTGCTGACGCAATAGGATACGCAGCGTATGACTTGCCATTTTAGCGGCAACATGGGTGCAAAGTCCGTCAACTTTCTTTCTAAGCAAGCGTTCGAGGTTGCGTCCTGTATTTTGTACCTCATTGAACACTCCCTCAATCCGTTCTCGAAAATGGTTAAGGAGCCGCTCAAAGGCAGCAGGAGTTTGTTGGTGTTGATTAACTCTTTTGGCGGTAAAGATACGATTGTTGGTAGTTCTTGATACCTCAGCTTGCCACTGGGTGCCAATAAAGCCCTTATCTGCCAGGATGTTACACCCCCGAACGAATTGTAAAACCACTTCCGCCGCTTCTCGTTCATCGGTATGAGCAGGCACAAGAGAATATACCAACGGCACACCCGCCAGGGTGCTTATAACCACCAACTTGTAGCCAAAATAATTCATCTTACGGCTAGCACAGTGACCATAGCTAGCGCTTCGGGTAAAATCACTCTGGCGTTTGCTACGCTTATAGCCCAATACGGGTATCGGTTTGGTATCAAGCAGTAGGGTACGCTCGAAGGTCGCTCCCATCTCGCTTACCCAGAAGCGTCGCAATTCCTCCAACAATCCTTCTAATCGCCGCACCCGTCGATTGAACTGGCTCTGATCTAACAATTTGGGAAACAGGTTGAGGTAGTTCGCCCGGATAAACCCTAAAAACTGCTGCTCACCAGGGTATGGAAAATAGTCCATTGCTAGCACTAAAGTCAACAGTTCGCTATCACTGAATACTGGTTGCGGTCCGGGCAACGAAGGAACAAGGCGATTGCCATGTTGAGTGTACCAATCATCCACTAATACATAAATGATGGTCAATAAACTGGGAGCGTCTATCATGTTCATAGGAGATATTAAGAATTGGTGTGGTTACCTTTATCTTGATGTCTCCCCTTGATTTTGAAAACCCTCTCTCACTCACATAAGGCGTATCCTTTTAAGTAAGGATACAGGTAACTACAACAGCAAAGATAATTTTTCAGGTATTTTTAATGACACCATCTGATGATTTACCCTTCCCTAGTGGCTAAAAACCCGAAAAGAGACTACTAATCTGTCAAAATAAAATTAACAGACTAGTAGATTAGTCGCAGAGGTGAGAGACAAGTGGGCATAGTAGTTGAAAGTGTATCGAAGCAATTTGGCGGATTTAAAGCTGTCGATGAGGTCAGCTTAGAGATTGATAGCGGTTCGCTGGTGGCACTTTTAGGACCATCAGGTTCAGGAAAGTCTACTCTATTGCGGTTAATTGCAGGTTTAGAAATGCCCAATAGTGGCAGAATCTTATTAACTGGTAAGGATGCCACAGACCAAAGTGTACAGGAGCGAAATATTGGATTTGTATTTCAGCACTATGCTCTGTTTAAGCACTTAAGTGTGCGGGAAAATATTGCTTTTGGGTTAGAGATTCGCAAGGCACCGAAAGCTAAGATCCGAGCAAAGGTAGAAGAATTGTTGGATTTAGTACAGCTGCGGGGATTAGGCGATCGCTATCCGTCTCAACTGTCGGGAGGACAACGGCAACGGGTAGCATTAGCCAGAGCTTTGGCGGTGGAACCCAATGTTTTATTATTAGATGAGCCATTTGGAGCGCTGGATGCGAAGGTACGTAAAGATTTACGTGTCTGGTTACGTAGATTACATGATGAAGTCCATGTAACTACTGTATTTGTCACCCACGACCAGGAAGAAGCCATGGAAGTATCTGACGAAATTGTGGTGATGAATAAAGGCAAAGTGGAACAGGTGGGTACACCTGCACATATCTACGATCATCCAGCATCCGCATTTGTCATGAGTTTTATTGGTCCGGTGAACGTGTTACCTAGTTCTTCGGGGATTTTCCAAGGTAATGGATTTGATTCAGTTCATCCAGAAATGTTTTTACGCCCCCAAGATGTAATTATTGACACCGAGCCTAGTGATACAGGCGTATCGGCAAGGGTGAGTAGATTAATACATTTAGGTTGGGAAATTCAAGTAGAATTGACATTAGATGATGGGCAAGTAGTAAGCGCGCATTTATCACGCGATCGCTTTGACGAACTAAACCTTGAACCGCAACAAAAGGTCTACGTTAAACCCAAAGATGCTAAATCATTTCCCCTTTATTACTCAATATAAACAAAGTAAAACAAAAAGAGAAGGTGATTAGCCTTCTCTTTAATGATTTCGGATACTTGTAAACTTTGGGGTGATGTAGAGCTTTGATACCCTAGCACTTTGACAGTAGTAGCTCTGGACTAATAGCATAATGCTGGACTATAATTCCGGTGCTTTGTGAATCAGTGTTTTTACTGTTCTAATCCAAATTAAGGTGACAATATTCATGGGACAAAGCCTCAGGGTTATTCAAGTAATGGCGAGTTTTTGGGGTGCTTTGACAGCGGTTCTGTTGTGTGGATTAAATACTTCAGTTCAGGCTGCGGAAACTGTAGTAATTCGTTTTGGAGAGTTTGCTGAGTCTATTTCCTTGGCAGAATTACAAACGATGGCAACTACAGGGAAATTTCCTGATGGCTATGGAATCTATACAAAACGCTTATCTGAACAACAACGTACACAAATTATCGGCGCGTTGCGAACAGAGATCCCTGTGGGTGTTGTAACAATGAATCGGTTACTTAATACCCCCGTTGGCACCACAATTTTAAATGATTTGTCAAAGGCTATAATTCGCAAAGATGCATCTGGTGTCCAAGCAATTCGGGCTGGTTTGGTTTTAGGTGCTACAGCACCCCAAGGACTTTCGGTGTTGAACTTTATTGCTGCATATCCCGGAAAGCGGTTAGAAATTGACTTAACCCAAGCATTCCAGGTTGGGAAAAACTTGAATGTGGCTTTTTGGCAAACCCAAAGGTTTATGGAAGCTTTAGCACCTCGGCTACAACCACGTAAAATCGATCTAAGTTTACCTTTCGATCCATCCCAACCTGGAACAAGTCAAGTTAAAGTCATCAATATCAACTTTGATGACACAAAACGTCAACGTCGGATTCCCATTGATTTATATTGGTCTGATGCAGTCACACCGAATCGTCCGGTAATTCTATTTACCCATGGTTTGGGTTCGGTACGCACAGAATTACGTTACCTGGCAGAACATTTAGCCTCCCACGGGTATGCGGTGGCGGCATTTGAACACCCTGGTAGTAATGGTGTAAATTTGGAGGAGGCGTTAGCTGGGAAAACTCGGTTGATGAAACCAGCGGAATTTCTCGAACGTCCCAAAGATATTAGTGCAGTATTAAATCAACTGGAAATTCTCAATCAAACACCTTCATCACCCATCAAGGGGAAACTGGCAACTAATAAAGCTCTAGTTTTAGGCTACTCTTTTGGTGGAAGTACAGCCCTAGTTAGTGGAGGTGCTGAGTATCAGCTAGAATATCTAAAACAACGCTGTAAGGAGAATTTAGCTACTGCTAGCTTAGGTGAAGGTATCCAATGTATCGCCCAAGAACTCCCCGAAAATACTTATCAATTGCGGGATGAACGAGTCAAAAGTATCATTGCCCTTAGTCCCACCACATCATTATTATTCGGAAATACAGGTTTATCTAAGATTACCATTCCCACATTGATGTGGAGTGCATCCGTAGATAAAACAACTCCAGCTTTAACTGAACAAATTATCAGTTTTTCGAGGATGCAACAGCCTAAATTATTGGCAGGGGTTATTGGTGCAACCCATCTCAGTGTTAAAGATCCTAGTGCCACAATGGATCAACGTGGTAAAATCAACACACCACTTAGTGGTGGAGAAGTTGTAGATACTCAAGCAGCAGATATTCGTAAATATCTTAAAGCAATTGTTGTAGCATTTGCAGCCCAGCTTACACCTGAAGCTGAAAAATATTCAATTTTTTTGACTTCAGACTATGCTCAATATGCTTCGACAAATGATTTTCCCATCCGTTTAATTCGGGAAATTCCTCCCGATGCGATGAAGGTTTTGGAAGAAATGAAATGAGTCGAGTTTTAGTGATGATATAGGGGAATTTTAATAATAAATTCTGTTCCTGTTTCTGCTGATGAATTGCAATCTAGTATGCCACCATGTTTTTCTGTAACAATTTGGTAACAAATTGAAAGTCCTAAACCTGTTCCTTTTCCTTCTGGTTTTGTGGTGAAGAAAGGTTGAAAAATTTTCTCTCTGGTTGATTCGGGAATTCCTTGTCCATTATCTTTAATTTGAATTGAGACATATTCCCGATCAAGACTGGTAGAAATATAAATTATTGGTGTAAACTCTTCTCCATCAGAGCTACGGGATTTACCTTTGTCGTACTCTTTACCTTCCATTTGTTCTTCAATTGCATCTATTGCATTTGCCAAAAGATTCATAAAAACTTGGTTCAACTGTCCCGGATAACACTCAATCATAGGTAAGTTACCATATGATTTCATGATTTGAATTCCCGAACGGTAAGTTTGGGCATTGAGACGATGCTGAAGAATCATTAATGTAGTTTCAATGCCTTCGTGGATATCTATAGCTTTTTTTTCTACTCCATCAGTGCGGGAATAGTTACGCAATGACTGCATGATACCGCGAATGCGATCGCTTCCCAACTTCATCGAGGAAATTAAACGGGGTAAATCTTCGCTGATGTGTCCCAAGTCGATTGTCTCGATTGCTTCCTCAATTTCATTTCCTGGAGTCGGAAACTTTTCTTGATAAAGTTTAACTAAATTAATCAAGTCATTGGCATATTGGTTGGCATGATATAAATTGGTCGATATAAAACCAATCGGATTATTCACTTCATGGGCAACACCTGCTACTAATTGTCCCAATGATGATATTTTTTCCGTATGAACTAATTGTAACTGCGTCCTTTTTAATTCCTCTAATGTTTGTGATAATTCTGCGGTTCTGGCTTGAACTCTTTCTTCTAACTGCTGCTTTTGTTCGTCTAATTCTTGATTTAGTCGTCTGAGTTTGATGTGTACTTGAATTCTTGCTAAAACTTCCTCTTGTTGAAATGGTTTAGTAATATAGTCAACAGCACCTAATTTTAAACCTTTAACTTTTTCCACAGAATCAGTTAAAGCAGTCATAAAAATTATAGGAATATCTTTTGTTTCTGGATCTGCTTGCAATCGCCGACAAGTTTCAAATCCATCTATTTTCGGCATCATGATATCTAATAATATCAAGTCGGGTGGATTATTTTTCACCTGTTCTATGGCACTTAATCCATCCATTTCCACTAGCACTTCATAACCAAGATTAGATAAGGTAGCATACAATACTTCTAAATTAGTTAAACTATCATCAATTACTAAAATAGTATCAAAAAGTCTGAAGGATTCTGTCGGAACTGATTCTGTGATTTCGGTAGTGCTGTTTAGGTGCTTTTCTAACATAATATATAATTATATTTTTGATGTAATTATCCTGAATCTATCCCACAACTATTTTTGAATATTCTCTTGTAAAAATTGACGAATTTTTTGAATATTCAACACTTTTACATACTTGTTCAAAGTTTTTACAAATGCCTCGTATTTTATGTCTTTGGTTGCAATCTTTTCTAGTTCTTGTTTAATTCCTTTAATTTGTCCTTTCTTCACATATTTCATTAGTGTTGTTAAATCTGACACTGGTGGAATTATGATTTCAACCTGAGATAATATTTCTGAAGATTCATTAGAATATGTATTCTGTTCCAGATATGGATCAAAGTCATAATCTCCATATTTCCAAACTAATTTTAGGTTTTTTTCTAATAACAAATATAGCTTCTCAACTTGTATTGGTTTAAGTAGTAAATCATTCGCTCCTGCTAGGATATTTTTTTCATAATCTCGGTCATAATTATATCTATTTGCTGAGGAAATAATAATGATGGTATTTTTAAATTCTTCTATATATCGGATTTTTGTCATGAATTCCCAACCACTCATGATTGGCATCTCCAGATCACATATAATTAGGTCTGGTTTCATGTCAAAACATTTCTTCAGACCTTCTTCCCCGTTAATTGCTTCACTAACAATAAAATTAAGTGGTTCTAATAGACTAACAATAAACGAACGATTTTCCCAGTTATCATCAATAACTAAAATCTTTCGAGGATTTCCAGAATAACCAATTAATTTACCATTGGCAGTATTCTTAATACTTTCAGTCCAATCTTCAGAAATTGGACATTCCACTGCAAATTCAAATAAACTACCCATCCCTAACTGACTCTGTACTTTAATTTCGCTACCCATCATCCGCACAATTGTTTGGCTAATTGCTAATCCCAATCCTGTACCGGATGTTTGACTATGACTATTTCCCAGTTTTTCAAACGGTAAAAATATTTTTTCCTGCTGCTCACTGATAATACCAATACCAGTGTCGGAAACTGCAAAATGGATCAAAACATTATCTAAATTATAACTTGTGTCTACTTGTAATGTTATTTGACCAGTATCTGTAAATTTAATTGCATTATTTAGCAAATTAACTAATACTTGACGTAACCTTTGTTGATCACCAATAAGACCTATGGGCAAATTATCGGATTTTTTATAAACAAATTCTATGCCTTTTTTTTCTGCTTGAAGACGGAAAAATTCTACCAATCCTTGAATTAAAGAAGGAAAATGAAAATCTTGGGAATTCAACTCTATTTTATTATTGTCAATTTTAGAAATATCTAAAATGTCATTAATCATGTTTAGCAAATTAAAGCCGCATTGATATATAGTATGAATTCCATGTTTTTGCTCTTCAGTTAAATTTCTAGAGCGAGATAAAATCTGTGCATAACCCAGAATTCCATTTAGTGGAGTTCGTAACTCATGGGTCATATTTGCAAGAAATTGATTTTGAGTTTGGTTAGCAATTTTAGCATCAGTTTTTAGCTGTTTTTCTGACTTTTTTAAGTCGGATATTTGTTGGCTAATCTCGTTTAATATATCAGTATAAACTATTAATTCATTGATGTTATTGGGTTTTATTTTTAAATCTAAATTAAGTTGGTGATTCATCCGTTTAAAATTACTTAATAAAGCTTCCACCGGAGATGCGATCGCATGATTAAGATATAAGCTAATAAAGTATATACATAAGACACTCAAAACCAAATTTAATAGAATAATTATTGTTTTTAAGACATAAGTATGCTGCAATTCTGCTTCTGCTTTTAGTTGTTGAGCTTCGGCAATTTGAATAAATATAGTTATCTGATTAATTAATTTTTGTGTATCTAGACTAGTTTGATTTTTTGATAGATCTTCAACCGCTCGAATACTAAATTTTGTGAAGTCATTTTTTCTAGAAATAGCTTCTAAGTTCTCGATAAATGATTTAAATATTGCTCCATAACTCAGCAATACTGGTTTTAAACCTTTGATGGATGAATTTTCAGCAGTCTGGTTTAATTTTTTGAAAGAACTCTTTGCTCGTTCTATTTTATCAATAATTATGTTTTTTAAATCCTGAGAATTTACAACTTTTTTTGAAGATAAAGGAAAACCTGGAACTAATTGTAAACTTAAAGTTGACTGTTGCAAATCAATCAACAGTTTACGTTCCCGTTGAATTTTCAATTTAGACTCATTTGCGTGATTATAAATCCTATCACTAATAATTAACCCTATCAAGTTTCCAGAAATTAGAAACCCTAAACCAATTGCATATCCTAAATTAATTTTTTGCTGGACCTTCAAATTTGTAATTAAATGCTTAATGGATTGTAAGGACAGCAAATTTTGTTTTTTTTCCAACAAATTTGCCATCTGAGTTTCTTTTTTTGAAACTTCTGCTTCAGAAGCAGGAGATTTCTTGATTGAGTGTGCCATTGGATAAGCTTATGCCTACGTATAATTACTCGGTTTCTACAAAATTATCTGATTAATTATTGCAGTATTTGCCTTGTATGCAAATAGCGATCAAAGTGATTTAAAAAGACAATTACAACAAAAACTACTTCAGCAGATTAATTGTAATTAGCTACATTTGACATGTATATATATTGCCCAAATTGCCGAAACTATTTACATTTAGGTAGATGAGGATTGCAAATTCTCATTCAAACAATTCGCCATACTGGCAAGTGAAGATGTGAGGTAAGTAAAGATTTGACCCCCACAGCAAACACGCTGGTTAGTGGTTATAGGGGAACTAAGTAGTGGGGAGTGAGTAGTGAGTGGTGAATAGTGAGTAGGGGTAAACGCAAACATTTGGGGTGGCTATGCCTAGGCTGTTGACTTTGATATGATTTTCACGCTTTTCTTTCATACAATTTTTGTGTCATCGACTATTCCCTAGGCTGTGCTTGGGAACCCTGATTTTGAGGATCCACCTCTTATCCTCACTGAAGGTGAACCCTCGAAATCTCTATTCCTTGCCAGAGACAAGGAACAAGTCATGTTACAGATATTGCGTGAACTTTTAGCTCCAAAAAAGCACATAGTCAACAGCCTAGACTTCTCTCCCGCGAGAGTTTTCCCCCCTGCTTCTTTTGACAACTTATTTTGTTGCGACTACCTGATATACCTAAAAAATTGCTAACTCTTAGTTTCCTGCCCGCAATTTATCTAATACTCCTCTATCTTCCAATGTGGAAGTATCTCCTGATACCTCTTCTCCAGCAGCTAAATTTCGCAACAATCGCCGCATAATTTTCCCAGAGCGGGTTTTTGGCAAAGCTTCAGTAAAGCGAATTTCTCCAGGACGGGCGATCGCACCGATTTCTTTAACTACATGGGATTTAAGTTCTTTACTGAGTTCATCGCTAGCAGTATGAGTTCCTTCGAGGGTGACAAAAGCAACTACTTCTTCACCTTTGAGATCATCAGGTTTTCCTACTACTGCTGCCTCTGCTACTGCTGGATGAGAAACCAAAGCTGATTCTATTTCCATTGTCCCTAAGCGATGTCCAGAGACATTTAGAACATCATCAACCCGTCCCATAACCCAATAATAGCCATCTTCGTCACGTCTGGCTCCATCTCCAGCAAAGTATAAATACTGCCCATCAATTGGGGCAATATGTTCCCAGTAGGTGCGACGGAAGCGCTCATCATCACCATACACTGTCCGCATCATACTGGGCCAAGGATAACGTACTACCAGGTAGCCACCATCATTATCATTTGCCGGATTACCGTCCAAATCTACCACATCTGCGAGGATACCAGGGAAAGGACGTGTAGCAGAGCCCGGTTTTGTGGGAATAGCCCCCGGTAATGGGGTAATCATAATTCCCCCAGTTTCTGTTTGCCACCAAGTATCGACGATTGGGCAACGTTCTCCACCAATAACTTTGTGGTACCAAATCCAGGCTTCTGGGTTGATGGGTTCACCTACGGTTCCCAACAATCGCAAGGATGAGAGATTACGGGTGTTAGGGTGTTGATCTCCCATTTTGATGAAGGCACGAATGGCGGTAGGTGCGGTATAAAAGATGGTGACACCATGTTTTTCAATAATGTCCCAGGTACAACCAGGATTGGACGCACGGGGAGCACCTTCATACATTACGGTCGTTGCAGCATTGGAAAGGGGTCCATAAACAATATAACTATGTCCCGTGATCCAACCAACATCGGCAGTACACCAATATACATCTGTTTCTTTGAGGTCAAAAATCCATTTTGTTGTCATGTGGGTATATAGGTTATAACCACCTGTGGAATGGACAACACCCTTCGGTTTTCCTGTGCTGCCGGAAGTGTAGAGGATGAACAGCATATCCTCGCTGTCCATGGGTTCGGCAGGGCAATCAGCCGAAACTGTTTTTTGTAAATCATGCCACCAGTGATCTCTTCCCGCTGTCATTGTGACATCTTGGGCGGTGCGTTTCACAACCAAAACGTTTTCGACGCTGGGACAGGCACCATCAGCCAAAGCTTTGTCAACTTGGGGCTTGAGGGGAACAATAGCATCTTTACGCCATCCACCATCAGCTGTAATTACTAGTTTAGCTTGGGCATCGTTTAAGCGATCGCGTAATGCCTCGGCACTAAAGCCACCAAAGACAACACTATGGGGTGCCCCAATCCGCGCACAAGCCAACATTGCCACTGCTGCCTCTGGTATCATCGGCATGTAAATGCCAATGCGATCGCCTTTCTTCACCCCGAGGCTTTTGAGGACGTTGGCAAATTGACAAACTTCTCGGTGTAGCTGTGCGTAGGTGATGGTGCGGGAATCTCCTGGTTCACCTTCCCAAATAATTGCCGCTTTGTTTTTGCAGGCAGTTGTGAGATGTCTGTCAAGACAGTTGTAGGAAATATTAATTTTGCCATTGACAAACCATTTAGCGAAGGGAGGTTGCCAATCTAAGACGGTATCCCATTTTTGGAACCAGTGCAGTTCTTTTTCTGCCAATTCTGCCCAAAATCTTTCTGGATTGGCTTTGGCAAAGTCGTAGATCTGCTGATAATCTTCTAAACTCTTGATGTTGGCATTCTGCGAAAACTCCAGACTAGGTGGAAATATTCGCTTTTCCTGAAGAATTGATTCTATTGTAGGTTGAGACATAGTGACGACTGCAATTCGGTGTTGCTACTGAAATCTATTTTTAGCAAGATTTGCTGACAAATGCTTAAATTACTCAAGTTTTTCTTTGAGGATTTTGAGCATTTGCCTATGCTGCTGAGAGTTTAGAACCGATACTGAGTCTTGTCTAGTCTTATAATGAGGAGATTTTTGAGATGATTCTACAAAAATGATGTCAAATATATATCAGATATAAAAATTAAAATTAGTTTAGAAAAATCAATACTACGTTCTCTGTAATGTTCCAACAAGTAAATGATCCAGAATCCGTCATTGCGAACGCAAGATCTAGGGATTGCCACGCTTCACTAGCCTCAGCCCTTAGCTGCATACTTTGTAAGCGGGAAGGCACTTCGTGTCTAAGTTACTTAAGCGCTTAGCCCTTTCAGGGCGGCTTCGCCTACATGTACGCTTGCCGTAGGATGCCCGAAGGGCTACACGGAACGCTACACGAAGGGCATACAAGAAACGGCTCTATGCCCTGCGGGCATCCAAGAAAGGCGCAGCCGCCCTTGTGGGGCTAGGAAAGGTTTTCTGCAATGACAATTGGGCATTTTTTTATTTGCAATAGTCTTGAGATCAACTAATAAGACTGTATGGTAAGGTGTCTACGTTTTTACTGTAGCCAGAAGTTTTTAATATACCTAACAAGATTAGAATACCGAACTGAAGCAAATCATATAATTAACCGCTACATTGCACTTTCAATGTATATTTTGGTAGTTTTTGATTTTTATCAGTTCAGGCATCCTTTGAATAAATCTAGGTGATGCATACACTTATTTTATTTTTCCAATTTAATAAGCATTACTTTTCCCGACAACTACCCATATAGTTTTGAAGATTAGCATTAAGTCATAAGCATTTGACCACTTTTGTTGGTAGTTAATATCCATTTTGACAATCGTCTCAAAATCTTTAATGCTAGAACGACCATTTACTTGCCATTCTCCAGTCATTCCTGGTTTAATACGCAACCTTTCCCAGTGATGAGGTTTGTATTTGGCAACTTCGTCAAGAGTTGGTGGACGAGTACCAACTAGACTCATATCTCCTTTGAGAACATTCCAAAATTGGGGAAGTTCATCAAGACTAGTGCGTCGCAAAAACTTACCCATTGGGGTTATGCGTGGATCATCAACACATTTGAAAATATGACCTTGGGCTTCATTTTTGACTAAGTGTTTCAGTCTGTCAGCATTAACAACCATAGAACGAAACTTCCAAATTCGGAAGGTTTTACCATTCAAACCACAGCGAATCTGACTATAAAAAATTGGTCCGGGGTCAGAAATAACTGTGATACAAGCTATGGGTATAAATAAGCAAGCAGTAATTAACAGTCCGATTACAGCACCAAAAATATCAAGCAGCCGTTTAGTATTACTTGATATGGAAGGGTGGATGGAATTTTGCAGATATTTAATTGAATCAGGGTGATTCGTAATTTTTTCCGCAGCAGAGCCATCTGCACTAAATATAAAAGCAGACATAGGTTGATAACAGTGTATTTACTTAAGTTTCTTGAGTTTTCTTTCTTCGCCTTACTCACCAATCATAGTCAACTTGTACGCGTATAAGAAAGACAAAAATCAAAATTTCATCTAATCTTGCTCTAAAGTGTCAGGTTTTTAAATTTACCGTATTTTTTCTTATGAGAGAAGAATAATAAATACTTATCCGAATTCTAGACTATATCTATATTCTAAGTCTTTTTTTGAGGTAAATACGTAGACAATTCAAGATGAAGAGGCTAAATAAATTACTCGTACGCAACTGTAATTTTATATAAACTTGACTAATGATCCGCAACTCGCCACTATATAACTTAATTCTTCAGCTGTTGAGGTTGTCTGGATGTCAGTTATGGGTAAAGATTTAACACAAGAATGGTTAGGGGAAATCCAAGGATTAAAGCAGCAGTTAGCTGAACTCCAAAATGCGCGGAATGAAGCTTGGGAAAGTGCCGAGAAATGGCGTAAACTCTATAATACTGAGGCTGAACAACGCCGTACTGATAACCAGTTGGCTCAACAAGCGATCGCGTCTTTAAACGGACAGCTACAAAAAATTAAGGGTATTGATGACAAAACCCTCCCCGATGCTGATACCTCCAGCGCGATTCACGCTGAGGTTATTCAACTGCAATCTGTGGAGGAATTACAAACCAAATTAATTGCGGCGACAAAAGAACGCGATCGCTTATTGCTAGCATTGAAGACTGAGCAAGAAGAACATGCGAAAACTCGCACGAACTTGACAACAGCCCTCGGAGATGCTATAGACGGCATGAAGCAAAGATCGTAAGCTTTCCAAATTTCATGAGATTAGAGTCTTTCAAAAAATAAATGATCCAATTTTTAAACTAGACCTATTTCTTTTATTCTCCCTGCTCCCTGCTCCCTCTAAAATCCCATCGCTTTTGCAACATCTAGAACATCTGGGGCAATACCCTGTTTAAATTGGTTGCCACTGTGTTTAATTGCCGTATCTGGATCTTTGAGTCCATTTCCGGTAAGGACACAAACAACTGTTGCACCTGTGGGAATTTGATCTTTGACTTTCAACATTCCAGCTACGGATGCGGCGCTGGCAGGTTCACAGAAGACACCTTCTTCTGATGCTAAAATTCTGTAGGCGTTGAGAATTTCCTCGTCAGTAACGGCATTAAATTCTCCCATACTTGCAGATTTGGCTGCCACTGCCTTATCCCAGCTTGCGGGGTTGCCGATACGGATTGCTGTAGCGATGGTTTCGGGGTGTGCTACTGGTTGCCCATATACCAATGGTGCTGCACCTGCTGCCTGAAAGCCCATCATTTTGGGTAAGCGATCGCACTTTCCCATTTGGTGGTATTCACAAAACCCCATCCAATAAGCTGTGATGTTTCCGGCATTTCCAACCGGGATACACAACCAATCAGGAGCATCACCCAGGGTATCAACTATTTCAAAAGCTGCGGTTTTCTGTCCTTCGATGCGGTAAGGGTTGACAGAATTCACCAATGTCACGGGATATTGTTCTGACATTTCCCGAACTATTTCTAAAGCGCGATCAAAGTTGCCTTGAATTGCCAAGACTTCAGCCCCGTAAAGCAGAGCTTGCGCTAATTTACCGAGGGCAACATAACCATCTGGTATCAAAACAAAGGCTTTCATTCCACCCCGTCGTGCGTATGCGGCTGCGGCTGCTGAGGTATTTCCTGTACTAGCACAAATCACTGCCTTGGCTCCGGCTTCTTTTGCCTTAGTGATTGCCATGGTCATCCCTCGGTCTTTAAAGCTACCTGTGGGATTTAAACCATCATATTTCACAAGTACCTTCACACCTCTACCAATGTATCTCGCCAGGGATGGGGCGGGAATCAGGGGTGTATTACCTTCCAGTAATGTCACAACTGGGGTACTTTCGCTCACTGGTAGGTAAGGACGGTAGGTTTCGATTAACCCAGCCCAAGGTTGGCGGTAGGATGTAGCAGGAGACAGGCTTACAGTCACGGTGTTTCTACAGTTTTTATAATAAATCAAAGTAAAAGCTATCAGCTTTTGGTTATGGGCGGCAAGCTTTATGACAGATCATAATTTGGACATTTATCTAGCATACGCTCTGCTGTGTACTGATTGCAAATCTAAACTTTATTTTTTGTATATTTTGGGCGATTAGTCATAAATACTCTCTATTCCCTAGCTCTTAACATAACTCCAGATTTATCGCTAGTGAGAAATCCGGGGTTAGTGTTGGCAATTTCCGAGCGGATTTTGGTAACATGAAATTAGCAATATTTTGCCTTGCAATAACTTAGCTTTGTACTAAGATAACGTCAGTTAAATATCATGACAGAATCAGTATTCAAACCAAAAGAACGTCGGAGTAGGATTTCTCTAAACAGTTCTTTATCACCCGAAGAGCTAGCTAAACGCAAAGCCGAACATGAAATATTTGCTCAACGCTGTCGAGAAATTTTCGATGGAGTACGTCCCCAAATAATAGATACATACTACGGTTGGTACATTGCCATCGAACCAGAGAGCGGAGATTATTTCATAGATGCAAATATAGAAATTGCCCACGATCGAGCCTTGCAAAAGTATCCCCACAATCATCATTGTGTTTTTTGTCTAAATGAGACAGGAGCCACTGGCACGATATGATTGAGGGGAATTTTGACGACATCGGGCATATATTTTTTGAAATTGATTTGATTACTACTGATGGATTGAATTTACCTGTAGATGCTATGTTAGATACTGGCTTTACAGGTTTTTTAGTCATTAATAAACAAGATTTAGAAGTTCTTGAATGGGTTTATCGTGGTGACGAGCAAATGCTGACAGCAAGAGGGGAAGCCATTTTTGAAAAATATTTGGGTAAAGTTTTCTTGGATGAACAAGAGTATGAAATTCCTGTTTATGCAGGAGATGAAATTACAGAAGTTCTAATTGGTTCTGCGTGGTTAAAAATTTTGCCTTTGGTTGTAAATTATCAAGCTGGAATATTGACGCTAGGATGAAAGTTTTTAGATTTGTTTGAGAACGCGAACGACTTACGACTTGCGTCGGACAAGCTACTTCGCGCAAAATAACCATGTACTAGAAAAGCGCGATACTTCGGAGCTTACCGTAGGCATCGCATCGAATTATCAAGCCTATTCAACTATGACTATTTTATTCCGGTAAAATCTCCTCCCGGTAAGGTTCGCGCAAAAATTCCTCCCGCGTCATCACGGATTGAGAAGTGTGACGGATATGGTAAATAGTGACAGCTTCTCCTTCAACTGTATAAAGTATCCGATAATTTTTTCTGTAAAAAAGACATCGAATATCCTGTCCTACTAAATCTCTTTCTGGAGCAATTGGACAACGCTGTGGCATGGAAGTAAGTGTCTCAACGACATTAAATAATCCATTGAACCATTTGGCAGCATTTTCTTTTGAATACTCGCCAATCCATAAATAAAACCCCTACCGCACTAGCAGATGCGGAGGGGTTATTTTAACGCGGTATATCATGCTTTGCTCGCAATGCTTCTAAAGCTTCGATCGCATCTTGTTCTTGTCCTGCGGCAACTTCTGCTATACTTTGCCGAATTGTGGCTGCTGACTTTGCTAATTCCAAATCATCTAATAATTTTTGGTAGGATGCTGCATCTTGTAGAACCACAGATGCCTTACCATTAACAGTCAAGACAATTGGTTTTTGGTTTTCCTGTAATTGCTCGATAAACTGCCGAGCGTTACGTTGAAAATCTGAAAGTGGGTAAATTTCCCGTAGATCGAGCATGGTTATGACCTCTACATGAAATATGCATGAAATTTAATGATATCCGATCGCGGTGATAAATTCCATTGTTTGTAGTTATAGCGATCGCAATTGTCAAAATTTACTTGGGTGCGATCGCTATTTCAGTTTAGACTAGGTGCGATCGCATAAACTAACCCTGTACTGGAAAAGCGCGATCGCTTACTGCTAGCATTGAAGACATATAGGCAATAGCTATATGTCCCCCCCTGACGCTTTTCCAAGTCACTCTCCACAGATGAGGAACAAAGCCATGACCTTACGGGTCTTCAGAATTACGAATGTAAGAGATTACATTCATTAATAAAAAATATAGAATATTTTAATTATTCTTAAAATCACACTATTATAATATTTCTATTGGTGTGAGTTAAATTTAAGGGTTGAATTAAGTAATGACAACATCTAGTGTTACCACTCGTGATTTGCACAGTACCTTTGTAAGCAAGACAAACAAGGCTTACTATCGGGAAGATCAGCAAGATAAGTTTATGCACCTGCAAGCTGAAGTAGACTACTTACTCCAGCAGTTGCAGAATTTGAAGCAGGAAAAATCTGGTACAGACACCTGCGAGAATTAGTGAGAATTTTGGCTCGGATAGAAACGACTACTCAAAGCGTTGATTTTTTCCAGACCAACGCTTGAGGCTATAACCTTTGCCATTTACCACTAGTAAAGCCAAAGAATCTACTTCTGCCAGTTTAGCGATCGCACTCAAGTTCTGTTGAGGTTTTTCAGCAAAGTCTGTGTAAATTATACTGCCACCATCGGAAAAAATTACCGTTCGTGGGGACTCTTTACCCTTTGGTTTTTTCGCCCCAGGATTTAGGGTTGCTAATGCTTCTGGGGAAATGGTAAATACTGTTTCAGCCTTACTGTTCCCTGTTAAATCCAGTCGCTGTACGAGCCAATTTCCAACTTTTTGTTGAATTTGAGGCAAACTAGGTACATCAGATTTGGGTATTTGCCCAGACGCTTGTAGTGATTTCCATAGTTTTGGTAAAATCACTTTTAGCTGCTGTAAGTTTTGCTGTGCCAATTCGGAAACACTAATTGGCAGAGGTTCCACCCACTCTAATGCGGAATTACTTACAGCTAAAGCGCGGTTAGCTTCAATAATATTTTCTGTGGGTAAAGCTAACAGTCGCAGGCTTCCACCTGCTAATTTTACAGCTTTAATGGTTGCGGTAGTGGCTTTTTGTTCTCCATTTGGCAACCAGATAGCAATTTGCAATAGTGGATCTGAATTTATCCCCAAATTTGACCACAAATACTTATCTGCTGAGGTTTTGGGTAAATTTAAATTATTAAATGGTGGGTAAAGCCAGCGTTTACCATCATGAAAGCCTGCCACCTCTACTTGATACCATTTTTGATGGGTAACTACATCCAACTTTTCTTCAGGTTGCAGCCATTCACTGGGATTTACTTTGGTAATTGCTTGGACTGAACCAATAATTCTACTAGGGTGATTGGGTATAACTGGGGACTTCGTAACTACTTCACCACGCAACTTGGCAAACAAAACTTTGCTATCGCTGAGTGTCTGGGAGGTTGCTTTTCTTTTCTGTAACCAAGAAGTTGCTTTCGCATTTCCTTCCCTCGCAGCTACGATTAATCCTCCCCATAGTTGTACTTCCGGACGGTTTTGATTCACTTCCAAAGCTGCTTCTAAGCGATTCCACAATCTACCATCATCGGTTTTGAGAAATGCAGCAATTTCTTGAGCTTTTTCTGGTGAACCCTGTTTAAATACCTCTAAAGCTTGACTCCAGCGTCCATCAATTAAGTTTGCTAGTATTTCTTGACTAGGACTTGCCCAGCTTTTCGCTGCTTGTGCTTGAGTAAGTTGGGAATGAAGACGAATGACTTCTATTTGTGCTTGTGCAGATACAGGGATATTTTTATTTTGCTTTTGAATGGATTGCAACCATGTATAAGCTGGAGTCCACAACCCGCTACGGGCAAGGGATAAAGCCTTTTCATAGTTATCATTTTTCCAAGCTGCTGGTTTGAGGGTTATTTCTACCAATTCAACCGGGTTGAGAAATAACTTGACTGATTTGACTTGGTAAACCAGTAGCTGAGGTTCCAAACCCACAGTTTGATTTATAACTAACCCCTGCTTTTGCCATTGGGGTAACTGTCCAGTGGGACTTGTCCACGACAACATTTGTTGAATGCGATCGCGTTCTGGATTGTAGTAGATAATATGTCCATATGCTGCGGTGTATGCTGAATCCTGTCGCTGTCCCCGCAAATAAAACCACATACCTGGGGATGGTGCTGCCTCCATTTGTCCAATTTCCGTCAAAGGTAATGCCACACTAGTACCGGGACTTTCATTGATGGCATTACTTAGAGGTGCAGCAACAAAGGATTCCTCTGGTCCTGTAACTGTCGTTTGGCTAATTAACTGGTATTTCCGAGTTACTTGGGAATCCCCATCTATTCCTTGTTGGTACAGTCGTAATTCAATTATTTCTTGACAATCATCTTGACAATTTGCCCTTTTTTTGTATACGGGCAATAAAAAACCTTTATTTTTCAAAGTCAAGGTTTCACCAGGAATGAGTCCTTGCTTGGTGATGGCAGTTTGAATTTGCTTCAGAGAAAGAGGGTTTTCACCCTGCATTGAAATTCTTGCCCATGTTGGCAGCACCTTATTTAACCAGGAAACCTTTTGCGGATTGAAGATATACAAAAAGCTAATCCAAGCAAACCCCACAACCAAACTACCAGTTCCCAGGAGGAATGCGATCGCTAACCAGGAAACTAAGCTGTTTTGACGTTGATATTTTTTCCCAGTCTTCTTAATTACCCGTTTGATGATGCGTGCATTCGGGTTTGGCTGATGTGGAGGGTTTGCCATACAATTTGTCTCTGTAAATCTCTCTAAGTTCAGTCCAGCATTTTTCTTTTATACTCGTGTTTACTCCATATTGCCCAAAAGCAAGTGATGGAGATATCGCCAAATATAAGTAAATTCTCCAATGCCAAAAGTAACTTTTATTCACTAAACTCAACCATGAAGTGCGTTAGTGAGATAATGATCAGGTGAAAAGCAGGCATTTTTACCCAGAACAAGCAGCTTGTATTACTTTCTGGCTAATCATAACAGGTGTTTTCGGCTTTCCCAATCAAGCTGCATCCGCAGAAGTTGCCGAAATCAGTAAACTTCCTCAACAAGTATCCCAAGTTGTGGAAACCTCAGATAGTTCAGATGGAGTTGTACTTGAAATCAGTAAACTTCCTCAAAAAATATCACAGGTTACGGAAACTGCTGAAAACTCAGATGAATCGATGTCACAGGTGACATCTGTATCTCAACTCAAAGATGTTCAGCCTACAGATTGGGCATTTCAAGCATTACAATCCCTAGTTGAACGCTATGGTTGTATTGCCGGATATCCTGATGGGACATACCGAGGAAATCGTTCCTTAACTAGGTATGAATTTGCAGCGGGGTTAAATGCCTGTTTAAATCGCGTGAATGAATTAATTGCCACTGGTACTGAAAATATTACTACACGCGAAGACTTAGAAAAGCTAAAAAAACTCCAAGAAGATTTTTCCGCAGAATTGGTTGCTTTGCGCGGTAGAGTTGATAACTTAGAAACACGTTCAGCCGAAGTTGCTGCAAATCAATTTTCTACCACCACAAAACTATCTGGTGTAAGTATTATTGGTGTTCAAGGACGCAGTAATAACCGTGCCGATATTAATCCCCGTGATGGAATAAGAGATACAAAAGACCCTGGTACAAATACTAATTTAATTACATTAAATCAATTATTTTTAACAACTCAAACTAGCCCGACTAGTTACTTAGTTACAGGACTTTTAGCAGGACAAGGATCAACAAATCCTCGAAATAGTAATGATATAACTTTGGGTTATGAATTTAATACTAATAGTAGCTTTGTATTAAGTGATTTGCACTATCATCAACTTCTTAGTCCTAAATTAGCAGTGATGATAGGAACCAGTAATGTTAATACAATTACGGCTTTTAGAGGTCCTAATCGGGTTGAAAATGCAGCAATCGGACCTTTATCTTATTTTGCTCAACGCAACCCAATTTTAGATATCGGCTATGTTGGACAAGCGGGAATTGCCGTGGATTGGCAGTTTAGTAAACGCGCTAGTTTACAAGGTATTTATTCTAGTGTAAGTGCCAATAATCCCAGCCAAAGAAATGGTTTATTTGATGGAAATACAACTGCTGGTGGACAGTTATTGGTGACACCAACTGATTCTATAGACGTTAGTTTATATTATTTAAATAATTATGCGGCTAATGGTTGCCTGCTTACATTTATTGGTGATGATTGTTTAACAGCAACTGATCCCATGACGAATAAAAGAGCACCTATCCAAACTAACGCCATTGGTAGTACTATTAACTGGCAACTTTCCCCCAAATTCACTATTGGTGCTTGGGGTGGTTATACTAATTCCCATATCCCTGGTAAATCTGGTAAGGTTGAAACTACTAATTGGATGGTATATTTAAACTTTCCTGATTTATTTGGCAAGGGAAATTTGGGTGGTATTTATGTTGGACAACCACCAAAAATTACCAACAGTGATTTACCTTTAGGGAGTAATGTTCCTGATTTTATTAGCGGTGGTTCAGGTAAATCTGGAGGACAACCGGGAACTACTACCCACATTGAGGCATTTTACCGTTTTCAAGTCACTGATAATATTAGTGTGACACCAGGTATTATTCATCTTATAGAACCGGGAAATACACCTGATAGTGATTCAGTAACGATAGGTGTTTTACGTACTACTTTCCTTTTTTAGTGAATTCGATGAGAGACAATAGGCTTTAAATTGCGTAGGTTATACTAATTAAAAAAATCATTACAACACATAGATAATCTCTAGGGGTTTAGCAGTGCTAAACTCCTAGCAACCCATCTGTCGTATTATTTTTGAAAATTGGCATTATAGCAATTTTAATTTATTTGAACCACACATAAATACTAAAACTTTGTCTAGATGTTCCACCAAAACGTATCTACGTGTCGTCTATTTACCTGAAAATTTCTGTAAATCAGGTGTGACTTAACCTAAACGAAATATTTTAAATATTGGGTTCCACTTTGTTTCACCCAACCTACGCATAGTTGTGGTTTTACTAAAAGAATTTTTTAGCTTTTTTGAATCCTTTATATGCAATTTTAGAGGCTTTTTTAGAGTATTTATACAAAGTTTTAGATGTTTCTTCAGCTTCTTTTGCAGCTATATAAGCTGTAACTACAGGAACCACTTTAGGTTGCACAACAATTGCAGTTGCTAATAATATCTTTTCAATATTTTCTTCTTTTGACATGATTTTTCTATGGTTTTAGTAAATTTCAGACTACTACTCCATAGTAATTAGTACCCCCATAAAAAAATAGCGTGAAAACTCCTATCAAAAATTAAATAATTAATGAAGCTTTGCAGCTATTACCTATCCTAAATTATATTATGTCCAGTTGATTGCCCATAATGTAGAGATGCGTTAGCGTAGCTCCTCCGCAGGAGGCTATATCGCATCTCTACAAAAGTTTTAATGATATTAGACATAAACACAAAGATTCTCAACTTTCTTGAAGAAGTCGGGGTTATAAAGCTATTAACAGTAAAGAATTATTCAATTTTGGCGCTGGGTATCTTGCCTGTGACATCATAAATATGGATTATTTATATTCTTGATTGCCCTCTCTAAGTATTAGTTGTAATTATGACAAATGCCAAAAATGTCCTGGGTGGTGAATTAGAGATTTGCTGTACTTCCCCAATGACGGGTTTCACTCGCAATGGAAAATGTGAAACCGGGATAAATGATATGGGTGTACATGTGGTTTGCGCGCAAGTAACTGAGGAATTTCTCAAGTTTACAAAGTTACAAGGCAACGATTTAAGTACACCTGCACCAGAATATGGTTTTCCTGGGTTGAAACCTGGGGATGGTTGGTGTTTGTGTGCAACACGTTGGCAAGATGCTTTAAAAGCTGGTGTTGCACCTCCGATAGTTTTAGCAGCAACTCACGAAAAGCTTTTGGAGTATCTTCCTTTGGAGGTGTTGAAAGAACATGCTTTAGATTAGATATTCTAGAGAATGGGTTACTTCCTATTAAAACTCTTCATTATAGGAAAGTCGCCCATTCACTAAATCATGCTCGTCTTCTAGTAGCCATAGTTTGGCTTTCTCAGAGTCTGAACTCGCAAAGATGACTTTATACTTGTCCTCGCTTCAATAATTTTTGTACTTGGAGAGTATTTGGTAAGTGTTTGGAAGTATGTCGAGAATCAAGAAAAATTTCATATTCAATACCACTCATAAAACGTGTAATAATCAGCAGCTACACAAAATTAAACTTTCTGAATAAATCGTTTCCCTAATAAACCTTGAGGACGTACCAATAACATAATAAACAGAATCCCGAAGGCAACAGCATCTTTATAACCAGAGTATTCTCCCGGTACAAATGCTTCGATGATACCGATAACGAAACCTCCTAAAACTGCACCGGGGATGCTACCCAAACCACCTAAAACGATGACTGCTAAACCTCGCAAACCAAAGGTAATACCGAAGTAAGGTCCTGCTATACTGACGCTAGATGCAAGTAGTGTCCCAGCAATTCCAGCTAAAAAACTACTAATAAAGAACGTTAAAACGATTAAGCGATCGCTATTTATCCCTAATAGGCTAGCAGTCATTGCGTCTTCTGCGATCGCTTGCATGGCTTTTCCATATTTTGTCCGATTGATAAACCATGTCATCATTGCGACTATCACAACTGAGACTATAAATATTATTATCTGTACAGTTCTTATCGGTATTGGGTTCTCTACTGTGCCGAAGTTAATTGATACTGGTAAATTTCCGTATGTATCACTGGGAAATGTGTAGTTTTCAGCCCCCACCATATACAGAATTAGATTTACAACTATTAACGCTACACCCAAGCTAGAAACCACCGTGAGTAATGCATCAGAACCTTGTTTACGGAGGGGAAGAAAAGCAAAACGTTCGATTGCTACTCCCACTAATCCAGACAAAATTCCCCCAATAATTAAAGCAGTTGCAAAGGGTAATTTAAATGGTAATGTTGTATTTGCTAGTAATCCACTAGACCCAAATGTCCCCCCCATTAATGCATAGGTAAAGTATGCACCAAGTGTGAATACTGCCCCATGCGCTAAGTTAATGATGCCTAAAATGGAGTAAACAAGGGTATATCCTAGGGCAAAGATTGCGTAGGTGCTACCAATTGATAATCCGTTGAGGAGTTGTTGGAGGAATATTGATATATGCATGTTATAAAAGTAAAAATCGTCAGTTTTAAAGCCCCAATTTGTTTAAATGATTTTGGGGTTTAAGTCCACACTATTAAAAGTAGCTAGTTTTGTCATGGGGTCTAAATCGCTGTTATAAAACTTAATTCCGAATTACTTTAATGAAGTCAGAATCAGAACTTACGCATTGACACAAAGGACAAAGTATGTTGATTTTAAAAAAGACATTTATCGTGAGGGTTTAGCAATGCTAAAACCCTACAACGCGGCTTAATGTACGATCGAAAAATGATTCATCAAAGCCTGAAATTCCCTATTTTCGTGGAAACATATCATGGTTAATTTGTATAGTGCGTAAGTCCTAAGAATTTTGCATATTTAGCTACTTAATAAACTCAAATTTACCTGCACTTCCATCTTTTTCCATTTTAATTTGAGCTACATAAAAGTCTTTCTGGACAATTTCTCCAATGGGTGTAAAGGAAATTTCTCCTATTGGGGTATCATATTTTCCAGCTAACATTTGCTTATTCAAATCTTCCCTAATTTTTGGAAGTTGTAAAGTACTAATTTTCGTCTTTTTATCTAACTCATTCAGTGCTTCAACATAAACTTGGACGGCTGTAAATGCTTGAGCGCTAAATTGAGGTGGTTCTACTTTATATTGCTGAAAATACATGTCACGAAATGCTTTATTAATTTTCCCAGGATGCTGTGGGCTATATGCTTGAGCAATAATTAATCCATCACATGATGCTTTACAAACTTTCAAGACATTAGATGAATTCAAACCATTTCCCCCAATAATTAAACCTTTGTAACCTAGTTCTCGCAATTGCCTAACTAAGTTTCCACCATCGGCGGCTAATCCAGATACAATTATTAAGTCTGGTTTGGCATTAATTCCATTAGTTGCTTGGGATTGAAAGTCTGTGTCTGTGGTTTGGAATTTCTGTACTGTAACAACTTCTAAACCTAAATCTTTGACTGTTTTTTGAAAAATTTCAGTTTCAATTTTATTGAAAGCATCATTTTGGGCGTAGAAAACTGCCACTTTTTTGATGTTGGGATTTTGTTTCAGTGCTGCTTTAACTGAATTGGGGGCAACAATGGAAGCTGGAGAGGAAACTCTGGCAACATAATCGCCAATTTCGGGAATACCTTTAGCTGTATTTGAAGCTGCCACAACTGGAACTTTAGCACGATCAGCTACAGGATGGGCGCTAAATCCTTGTTGTGATAAAGTAGGTCCAATTATACCTACTACTTTATCTTTATTAATTAATGTTTGAAAAGCATTGATTGCCCCTTGTTCTTCCCCCCCTGTATCTTGAAAAATTAGTTTAATTGGAGTTCCATTAATTCCACCTTGATCGTTAAAATATTTTTCAGCTATTTTCGCACCATTGGAACCTTCTTGTCCTAATAATGCAACGTTACTGGTTTGGGCAAAAGCGATACCAATGGGAATAGTTTGGGAAGTTTTGGTACTGTTAGTACAAGCTGTAATAGTAATTGAAAGGGCTGTAAATAAGATAGTTTTGAATGTAGGTGTTTTTGACATAATTGAATATTTGAATTGTATTTGTAAACTGGGTTTTGCTACACCCAATATTGGGAAATGAGATCGATGCTATGATCAACACAGACTAATGTTGAATTCCGGAAAACTACGGAAGTGAACGCAAAGAAACGTAGAGTCACACATACCTCACCGTTCAACGACGAGACTTCCTGTAACTTCTTCCACTATTAAGCCTCTTGGTCAAGTGAATTTTGTCATGTTTATGGGAGCATGTAAAGCTAATTTTCTCAGCTTTACCACTACAGACGCTCGAATTGTCGCATAAACTGACGATCTATATAGTCCTTCCAGTACCACAGCAGTTTGTGGGGTGGTAATGTTAATTTACCGCGTGAGGCGTAGGCGTAGCTAATCGTAGATATCGCGTTACCATCTCCGGTACCAATTAAACTTAGATAATTTTGTTGGGGTATGTATGGTTTCAAAGGTTTTCCCCATACTGCTTGCCGTAAATTCCTAAATAGTGGTTTTCCTTGACGGACTGCAAATACTCCTGCTTTGGGACGAGGATGGTTTACCATAGTGGCTATATCTCCTGTGGCAAATACGTGGGGATGGGAGATAGATTGCAATGTCTCATCTATCAAAATAAATCCCTCTGCATCCACTGCTAATCCGGTTTTTTGTATCCAGGGTGCTGCCGATGCTTGTGTAACCCAAAATACATGCTGAAATAAATCTGGGCAATTAGTGATTTTTTTATATCCTTGTTCTGGGAATACCTTTTCAATTTGGGATAATTTGCCCAAGTGCAATTCTACTCCTCGTTGCTGCAATATTTTTTTCAGCAACTTCCTCAATGAAGTTGAAGAATTTGACATTAATTCCCTCCCACTGTGAAAGAGGTGCATTTCCAACTTCCTACTTCCCAATTGCTGTAAACCTGCTTGTATTGCCAAGGTTAATTCCACACCTCCTGCACCCCCACCCACTACAGCTATTTTCATCGGTGTTGAGTCTTTGGGGAAATCTTGACAAATTTTATACCACGCTTCCAATAGCTGAGGTACAGGTTTTGCAGGAATTACATGCTTTACATTTACATTCCCTATTTTGGGAGTAAGCTTAGACGCATTTAAATGACATTAACAGAATTTCCTTTATTTTTTACCTTCCTAGTCCAATTAATAATTAATTCCCCTTCGTTCAAAAGTTTATTTACTATTTTTTCTAGTTCTTCTTGTGTTTCAAATTCTCGATGAGCTATATATTCTTTAGCAGAATGCCACACTAATTCTATTAAATTATAGTCAGGACTATAAGCAGGTAAAAATTCCAACTTTATATTAGGTAATTCTGATTCTATTTTTTCTAAAAACTCTTGCTTTTTATGAAAGCTTGCGTTATCTAAAATTATGATTATCTTTGGACCTTCGCTGTGAAATTTTTGCGGTTCATTACCTTGAAACTCCCATTCTTTACGTATTTGCTCATTCAAACAAATTAACTGGTTATAAAATGTTTCCGAATTTCCTTTTTTTATCACAAAACATATTCTTCTTTTATCCCCATATCTTAATCCTCCCATGATATTTACTCTTCCTCTTCTCCTCTTTCCTTTTATTTTTTTCTCTTCCCTTTTTTAGTCCAACATCTTCTTCTTATCACTCTTAAGCTAAAACCGCACTCATCCCAAAACCATACCTGAAGTGCATTTGGGCTCTCTTGCGCTAATCTCAAATAGTCTAATAATTTTTCTTTGAACTCTTCTCTTTTTTTTTATCTTGTTTCTCTTCTAAACTATATTTTCCCCAAATATATACATATTTTTCTTGTGATAGTATTCTGCTTACTTGCGATTTACTCAGTTTTATTCCTGTTTCTTTCTCTAGATGCTCTGATAATCTTTTCCCTGTCCACCTCCCAAATTCATACCCGAATTCTTTCGGTTCTTTATCTATAATTTTTAACAAACGCTCTATATATTCTTTACTCGCTTTGCTGTAATTACCTTTTGCTCTTCCATCTTCTAGTGTTTCTAAATTATTTGGATCTCCATGAACGCACCAGTAAGCTACTCTTCTTAGGGAGCATCCTACAAACTCGGCTATCTTCTCATACGTCTTTCCATCATTCAAAAGCAACAACATTAAAGCTCTTTCTCTTATCTTCGGATTTTCTTCCGTCTTTACTGCCTGTTGTAGATTTTTCTTTTCTGTTGATGATAGATGACCCTTCGCTGGCATTTCGGCTTATTATCTAAATTTGCTGCTTTTATTTTATGTCATCTAGATGCGTTTTAGCTTACTACCAATATCAATTGACACTATGTCAAAAGCTATTGGTAGTATATTCTCGCATATTACTAACTTTTTTTCTAAATCTAAATTTACCACCCGCTCAACATAAAATTCTGCTTGGGCAGAAATAGTCAACCGTCGTAGATTAATATGACATTGACTGCGACTGTAAAAGCCAGCAATATGTCCTGGTAACATCCCCGAATAGGGAGTATCTTCAGCATCACTAATGAGAGTTAGATGTAAACCTGGTACGGGATTTGTAGCGAAAAACCGTAATGCGATCGTATGACTATGACCGCCGCCTATCATGACTAAATTTATCATAACTTTTTATTTCCTGGTTTCTTTCTCTGGTTTAACTCACTAAAATGGTGGAGTTTGCATCTGCCGTAGACTAGATAAAATCAACAAAAACGAAATCAGGAACAATCAAATCATCACGACAAAGATGCTAAAACAAACCTTACAACGGCAAATCAAACAACTCAACTCCCAAGAAATTCAAGAGCGTTTACTTGCAATTAATCAATTAGAACAAATTACCAAAACTCATCCATCCCATCACTGGTATATCATGGAGGCTTTGAGTAATTTTCTGCGTCAATCAGCACCAATAGATAATTTAGACATAATTTGTATTGATATTCAAACAGCACTGCATGTTATTTGTAATAGAAATGTTCAACATGATCCCAAAAATCAAATATTAGATCTTAGTTTTACAAATATTCCTAATGTGAATCTAGATAATACTAATTTACAGCAAATAAACTTTTATCAAAGCAATTTAACGAATGCCAGTTTAAAAAATGCCAACTTACACCAAGCAATTCTCGCTGCTGCAAACTTGAAAGGTGCAAACCTTGAAAGGGCAAACTTAAGTTCAGCAAATTTAGGCGCAGCAAACCTCACAAATGCAAATCTCCGCGCTGCTAATTTACATCGAGCTAATTTATACTTAGCCAATCTTGAAGGGGCAATTGTTCAAGAAGCAAACCTCTGGGAGGCAAACTTGAGAGAAGCTAACTTCAAAGGTGTCAGGCAACCTCTGAATTCGTAAATATTCGGGATAGTTGTATCATTCAGTTGCTGACAATATCCAGTAATATACTGACAAATATTTGAAAAATCTTATCTATTTTGTATCAGTTACGTAAGGGCATAGTTTACTTGTAATTTTCGGATTACGGTTACTTACACCTCTACAAATAAGGGCAAACGGTTGTTTGCCCTTATGATGTGTTCCATTCTTTTTTCCAATTGGGATTAAAATCTACTGTATAAAAAAACCTCATCTTAAATTAACATTCAAGATGAGGAAATAATTAATCATCAAAAAAACTAAAAAATCTGTTCTAACTTTTGAAAATCACATTGCACTTCATAAAGTAAAGATTTGTTATGCGGATCGGTTTTCATGGCTTTTTTGAGGTATATCCTTGCCTTGAGCCATTGTTTTTCGGTAATTAATGCCCTTGCCCAAACTTGGTAAGCTACAGCTTGCCATTGCCTAACTTCAGCATCATCAGGTAGACGTTCAGCCAGTGCTTCAGCGAGTGCGATCGCTTGGGGAAAGCGACGCTCTTGGAGAAAGCGCTGTAGTTGCTCGTAAGTCTTCCACTTCAAGCGTTGTTCAATTTCTGCCAAATTCGGCGGTTTAGTTTGTACTCTTTCTTTCGCCACCCCAGTAGTTGCCTCAGCAGCAGCTGGGGACGTGCCAGAGGGTTTTCTAGTTGTTGCAGTTCGTTGTTGGGTTGTAGCTTGTCGTGTGGCTTTAGACTGTGGCATTACAACATCAGTCGCTGGCAACACCTGCAACAGCAACTTATAAGCCTCAGTTAAGGCAATAAACTTATCTTTCGCTTTTCTATCTTCTGGATTTATATCTGGGTGATAGAGCTGCGCCAATCTTCTGTACGAAGATTTAACATCAGCGAACGAGGCACCAGTCCTTAAACCCAATATACGGTAGCAATCTCCAAGATCCATCTTGAGCTATCAAAAGCGCGAATGTCAGCTTTAATTAAAGGATAATCATGAAGCTAGAGGAAATAACCCTGTAAGAGGCAGCTTTCTCTAACTTTTGCCAATCTCCACACCAAAGCCAGAAGCTTCGATATATCGAAATAGCAATCTACTTTATAGTCATCAGTTATCAGTTATCAGGTTGAGTTCAGGTCGTGCTGTTTACTGTTCACTGCATTACTGATTTAAATCAGCATTGACAATTTTTTCATTCCTGAAGTTTGTTCTTCCGGAAACTTAATTATGCTTCCTAATTGCCAAATTGTTGAAATATTCAGTAATTATAATAATCACGCTACATATACTACCCCCTGAAGTTATGTCTTGCAAAGGGGTAATGGCACATTCTCTTTTTATTCGTGTCTTATTCGTAACAATACACGAAACCCCTTCCGGAAGTTTGTACTTCTAAAAGGGGATAAAAGTAAAATTTTCCCTACGTGATCTTGTCGATACTTTTTCTATAGGGGATTAGGATTTGGTGTACTGGAACAAGAACCACCACACCTAAAATCTGGACGAAATTTAGAACGGTTTCTCTTCAATCACCCGATCAACCAAACCATACTCTTTTGCTTCAGCGGCTGACATGAAAAAGTCACGATCCATATCTTTTTCGATTTTTTGCAGTGTCTGACCTGTAGTATTGGCGTAGATATTATTAAGTTGATGGCGAATTCGGATAATTTCCCTCGCTTCAATTTCGATATCAGTAGCTTGTCCACGGGTTCCACCAGAAGGTTGGTGAATCATAATGCGCGAGTGTGGAAGTGCCAAGCGTTTACCCTTGGTACCCGCAGTCAAAAGAAAAGAACCCATCGAAGCCGCCAAACCAACACAAATTGTTGCTACATCCGATTTTATGTGCTGCATGGTGTCAAAAATAGCCAAACCAGCACTCACCGAACCGCCAGGGGAATTTATATATAAAATAATATCCTTACCAGGATCTTCGGAATCGAGATAAAGCATCTCGGCGATAATTTTGTTAGCGATGTCATCATCAACTTCTCTTCCTAAAAAAATAATCCTTTCTAGGAAAAGACGGTTGTAGATATCAATCCACTGTGTTTGTTGTCCCCCCGGCAAGCGGTAGGGAACCTTGGGAACGCCTATGGGCATTTTGGGGAAACTCCGTTTTCAATAACTGGGATAGGTAATCTGAGATATTTGGTAGATATGGGGCTTGATTTAGGAATTAAAGCATAGTTTTTTCCCACTACCGATTAATCTATCTCAGATTACAAGATGCTAGCTGGTAGAGGAGGATTAGCCACCTCATTCTTTTCAAACACTCGATCAATCAGACCATATGCAACAGCATCATGGGGAGTGATGTAGAAGAGGCGATCCATGTCCTTCTCAATTTTTTCCTTGGTTTGCCCAGTATTTCGTGAGAAGATATCAAGCATTGTGGCTTTGTTTGCCAAAACTTCCTTTGCCCTGATTTGAATATCTGTAGCTTGCCCTTGGGCGTAGCTTTTAGGCTGGTGCAAAACAATCGAAGCATTTGGTAAACTGGCGCGACAGCCTTTGGTGCCAGCGGCAAGCAGCATGGCAGCCATACCCATAGCCGAACCCATACAAATTGTATGGATGGGGGGCTTGATGTATTTCATTGTGTCGTAGATCGCAAAAGCTTCTGTTTCAAAGCCAACGGGATCTCCAGTGTAACCGGAGGTGCCAGTCGAATTGATGTAAATTTTGATTGGCTTTTCTGGGTCGTCTGACTGTAAATACAGCAGTTGGGCAACTATTAGTTCTGTCACAGCAGGCACCAGTGGCAGACCCAGGTACACAATTCTTTCCTTAAGGAGTAAGGATTCTAAATCTGGTGGCGGTGTGCGGTATGAGTTTTCGCCGGAATAAGCGGCTTGCACAGCCTTGATGGGGGAGATGTCCAT

Protein sequences of DBSCAN-SWA_4

>NC_019751|3927849:3988730|3942041_3942335_-|WP_015198901.1|DBSCAN-SWA
MQFNFFKPQNNDDYSDIKQEIIRELLRMTRKSYNLALSITAASALITLFGVGLLYFDKVSEASLTASGGVLTTLLSVQHTKDKKEELCEMLKLLSEK
>NC_019751|3927849:3988730|3948368_3950276_+|WP_015198905.1|DBSCAN-SWA
MCGIVGYIGTQAATEILLAGLEKLEYRGYDSAGIATIWEGEVNCVRAKGKLVNLRSKLEQVDSPAPIGIGHTRWATHGKPEEHNAHPHMDTTNRIAVVQNGIIENYRELREQLKSSGVEFRSETDTEVIPHLISQFFLEEIAVSEDTNSATSPFFVAVLKTVNQLEGAFAIAAISADCPDELIVVRQQAPLVIGFGQGEFFCASDTPAIVAYTRAVLPLENGEIARLTPLGVEVYDFSGRRLKKQPRLLNLSPTMVEKQGFKHFMLKEIYEQPEVVRASLNAYFNLDWKAETNQDSPINLGIPAELYADLEQIQIVACGTSWHAALVGKYLLEQLADIPTQVQYASEFRYSPAPVTANTITIGVTQSGETADTIAALAMENDRRQGRESKYQAKLLGITNRPESSLGHMVPHIINTLAGIEIGVAATKTFIAQLMAFYALALDLGYRRQSIPGELMEEILEGLRQIPAEIESTLEQQEKLTEHLAHEFAETQDFIFLGRGINFPIALEGALKLKEISYIHAEGYPAGEMKHGPIALLDAKVPVVAIAMPGSVYEKVISNSQEAKARDSRLIGVTPITDGEAGEIFNDLLPVANVDELLSPILTVIPLQLLAYHIAARRGLDVDQPRNLAKSVTVE
>NC_019751|3927849:3988730|3942560_3943937_+|WP_015198902.1|DBSCAN-SWA
MRESDKVRSSESGKARLKQAYKEAGLKQDELARQAIVSVDTLKRLLGTKDCPNGVERQAVKNIAKILKIKPTDIVDVKDWYPQQQLPAEFERLIYEKTQLFCGRKFVFDSIEDFFQNNPNGYFTIIGDAGMGKSAISAKYVLDNPETICFFNIRAEGTNRPELFLKKIRQQLIARFQLPDVADADLSTLLTKAKEKLSTGERLIIVVDALDEVDQEGTANILYLPTILPDGVYFILTRRPYNQNEKRLNLSPSIPTQELDLREKIQESVQDVKEYIRELLSDGKYQQGLAEWIQQQNHISHEDFVETIAVKSENNFMYLRCILPAIAEGYYKDKPLNELPVGLEGYYENHWHIMGMTAKPLPKNKIKIVYVMCALRSAASREVIAKYSKQNALTVQEVLDGWAQFLQKQESYQPPRYRFYHESFREFLHRRDIVQAVGVNLPDIGAEVANNMTEGLIL
>NC_019751|3927849:3988730|3941567_3941876_-|WP_015198900.1|DBSCAN-SWA
MLLQELQEQVFKLPPSDAIIESLQNDLIPQPNRSDAIRRMRGLLKTDQPAPTDEEVAAMLEERRVEKDPLLKLIGSISVDIPDLAENHDYYIGQTLTNFALP
>NC_019751|3927849:3988730|3974278_3976543_-|WP_015198922.1|DBSCAN-SWA
MANPPHQPNPNARIIKRVIKKTGKKYQRQNSLVSWLAIAFLLGTGSLVVGFAWISFLYIFNPQKVSWLNKVLPTWARISMQGENPLSLKQIQTAITKQGLIPGETLTLKNKGFLLPVYKKRANCQDDCQEIIELRLYQQGIDGDSQVTRKYQLISQTTVTGPEESFVAAPLSNAINESPGTSVALPLTEIGQMEAAPSPGMWFYLRGQRQDSAYTAAYGHIIYYNPERDRIQQMLSWTSPTGQLPQWQKQGLVINQTVGLEPQLLVYQVKSVKLFLNPVELVEITLKPAAWKNDNYEKALSLARSGLWTPAYTWLQSIQKQNKNIPVSAQAQIEVIRLHSQLTQAQAAKSWASPSQEILANLIDGRWSQALEVFKQGSPEKAQEIAAFLKTDDGRLWNRLEAALEVNQNRPEVQLWGGLIVAAREGNAKATSWLQKRKATSQTLSDSKVLFAKLRGEVVTKSPVIPNHPSRIIGSVQAITKVNPSEWLQPEEKLDVVTHQKWYQVEVAGFHDGKRWLYPPFNNLNLPKTSADKYLWSNLGINSDPLLQIAIWLPNGEQKATTATIKAVKLAGGSLRLLALPTENIIEANRALAVSNSALEWVEPLPISVSELAQQNLQQLKVILPKLWKSLQASGQIPKSDVPSLPQIQQKVGNWLVQRLDLTGNSKAETVFTISPEALATLNPGAKKPKGKESPRTVIFSDGGSIIYTDFAEKPQQNLSAIAKLAEVDSLALLVVNGKGYSLKRWSGKNQRFE
>NC_019751|3927849:3988730|3927849_3929304_-|WP_015198891.1|tRNA|DBSCAN-SWA
MTVRVRIAPSPTGSLHIGTARTAVFNWLFARHHGGTFILRIEDTDEERSRAEFTDNILDGLRWLGLTWDEGPFFQSQRLDIYKQAVQKLLDKGLAYRCYTTAEELDTLRELQKAKGDAPRYDNRHRNLTPQQEAAFQAEGRSFVIRFQIDDGREIRWHDLVRGEMVWQGRDLGGDMVIARAAEDGVGQPLYNFAVVVDDMDMDITQVIRGEDHIANTAKQILLYEAFGAKVPEFAHTPLILNQEGRKLSKRDGVTSISDFQQMGFTPEALVNYMTLLGWSPVDSTQEIFSLAGAAQQFGFERVNKAGAKFDWAKLDWINSQYIHAMPVNKLTDMLIPIWEAAGYKLDGKRHERAWLEQLTGLIGASLTRLTDAVAMTKPFFGDTIEFQPEATTQLQQPGSVTVLEEVLKILAQGQELTEASAQDIIKQVMKAQNLKKGVVMKALRSAISGEVHGPDLIQSWLLLNQLGLDQPRLQNAITAQANF
>NC_019751|3927849:3988730|3929576_3931037_-|WP_144051128.1|DBSCAN-SWA
MGEIFLAHDILLGGTPVAIKFLSGMISDSKMQADFAHEARTCAILSQRSIHIVKVTDYGISNAGKLYYIMEYLEGKTLSDLLPLSLPTFLNITFQICLGLQCAHEGINIDGKISPLVHRDIKPANILVVSDLILGQLVKILDFGIAKFSHNPTLIKTHQDVCGTLPYCSPEQLENQELDCRSDIYSLGVLMFEMLTDHKPWKPDTDYLGAWYTAHHFQSPRTITSVSPNLQIPQELNQLIMACLAKNPQDRPQRIGELIAVIQDLKNSAMKLPSLYTQAAKSSPNIINKYSLANTGLSKTIEKACWQLPWSKDKPIRQIVFPLHLNTENGKITALSLMMSKSEIEKYVTSTHYNEFAFIAAPYPTLLWVTLLYSREYGKKWLPCYLDMQNSQHLKLVGSLAECDRYPLICYTQEPPHDCLTVLAATISLQQRQMLKTWLQQSQTLPSAPAGNFQLSKNLLKQHYKEIQSRVMSQFVDKILYASSQS
>NC_019751|3927849:3988730|3966383_3968354_-|WP_015198914.1|DBSCAN-SWA
MSQPTIESILQEKRIFPPSLEFSQNANIKSLEDYQQIYDFAKANPERFWAELAEKELHWFQKWDTVLDWQPPFAKWFVNGKINISYNCLDRHLTTACKNKAAIIWEGEPGDSRTITYAQLHREVCQFANVLKSLGVKKGDRIGIYMPMIPEAAVAMLACARIGAPHSVVFGGFSAEALRDRLNDAQAKLVITADGGWRKDAIVPLKPQVDKALADGACPSVENVLVVKRTAQDVTMTAGRDHWWHDLQKTVSADCPAEPMDSEDMLFILYTSGSTGKPKGVVHSTGGYNLYTHMTTKWIFDLKETDVYWCTADVGWITGHSYIVYGPLSNAATTVMYEGAPRASNPGCTWDIIEKHGVTIFYTAPTAIRAFIKMGDQHPNTRNLSSLRLLGTVGEPINPEAWIWYHKVIGGERCPIVDTWWQTETGGIMITPLPGAIPTKPGSATRPFPGILADVVDLDGNPANDNDGGYLVVRYPWPSMMRTVYGDDERFRRTYWEHIAPIDGQYLYFAGDGARRDEDGYYWVMGRVDDVLNVSGHRLGTMEIESALVSHPAVAEAAVVGKPDDLKGEEVVAFVTLEGTHTASDELSKELKSHVVKEIGAIARPGEIRFTEALPKTRSGKIMRRLLRNLAAGEEVSGDTSTLEDRGVLDKLRAGN
>NC_019751|3927849:3988730|3958972_3959989_+|WP_015198910.1|DBSCAN-SWA
MGIVVESVSKQFGGFKAVDEVSLEIDSGSLVALLGPSGSGKSTLLRLIAGLEMPNSGRILLTGKDATDQSVQERNIGFVFQHYALFKHLSVRENIAFGLEIRKAPKAKIRAKVEELLDLVQLRGLGDRYPSQLSGGQRQRVALARALAVEPNVLLLDEPFGALDAKVRKDLRVWLRRLHDEVHVTTVFVTHDQEEAMEVSDEIVVMNKGKVEQVGTPAHIYDHPASAFVMSFIGPVNVLPSSSGIFQGNGFDSVHPEMFLRPQDVIIDTEPSDTGVSARVSRLIHLGWEIQVELTLDDGQVVSAHLSRDRFDELNLEPQQKVYVKPKDAKSFPLYYSI
>NC_019751|3927849:3988730|3987351_3987948_-|WP_015198931.1|protease|DBSCAN-SWA
MPIGVPKVPYRLPGGQQTQWIDIYNRLFLERIIFLGREVDDDIANKIIAEMLYLDSEDPGKDIILYINSPGGSVSAGLAIFDTMQHIKSDVATICVGLAASMGSFLLTAGTKGKRLALPHSRIMIHQPSGGTRGQATDIEIEAREIIRIRHQLNNIYANTTGQTLQKIEKDMDRDFFMSAAEAKEYGLVDRVIEEKPF
>NC_019751|3927849:3988730|3972205_3972523_+|WP_015198918.1|DBSCAN-SWA
MTESVFKPKERRSRISLNSSLSPEELAKRKAEHEIFAQRCREIFDGVRPQIIDTYYGWYIAIEPESGDYFIDANIEIAHDRALQKYPHNHHCVFCLNETGATGTI
>NC_019751|3927849:3988730|3973036_3973318_-|WP_083866321.1|DBSCAN-SWA
MGEYSKENAAKWFNGLFNVVETLTSMPQRCPIAPERDLVGQDIRCLFYRKNYRILYTVEGEAVTIYHIRHTSQSVMTREEFLREPYREEILPE
>NC_019751|3927849:3988730|3976974_3978483_+|WP_083866374.1|DBSCAN-SWA
MSQVTSVSQLKDVQPTDWAFQALQSLVERYGCIAGYPDGTYRGNRSLTRYEFAAGLNACLNRVNELIATGTENITTREDLEKLKKLQEDFSAELVALRGRVDNLETRSAEVAANQFSTTTKLSGVSIIGVQGRSNNRADINPRDGIRDTKDPGTNTNLITLNQLFLTTQTSPTSYLVTGLLAGQGSTNPRNSNDITLGYEFNTNSSFVLSDLHYHQLLSPKLAVMIGTSNVNTITAFRGPNRVENAAIGPLSYFAQRNPILDIGYVGQAGIAVDWQFSKRASLQGIYSSVSANNPSQRNGLFDGNTTAGGQLLVTPTDSIDVSLYYLNNYAANGCLLTFIGDDCLTATDPMTNKRAPIQTNAIGSTINWQLSPKFTIGAWGGYTNSHIPGKSGKVETTNWMVYLNFPDLFGKGNLGGIYVGQPPKITNSDLPLGSNVPDFISGGSGKSGGQPGTTTHIEAFYRFQVTDNISVTPGIIHLIEPGNTPDSDSVTIGVLRTTFLF
>NC_019751|3927849:3988730|3982797_3983505_-|WP_051036686.1|DBSCAN-SWA
MKIAVVGGGAGGVELTLAIQAGLQQLGSRKLEMHLFHSGRELMSNSSTSLRKLLKKILQQRGVELHLGKLSQIEKVFPEQGYKKITNCPDLFQHVFWVTQASAAPWIQKTGLAVDAEGFILIDETLQSISHPHVFATGDIATMVNHPRPKAGVFAVRQGKPLFRNLRQAVWGKPLKPYIPQQNYLSLIGTGDGNAISTISYAYASRGKLTLPPHKLLWYWKDYIDRQFMRQFERL
>NC_019751|3927849:3988730|3961846_3963238_-|WP_015198912.1|DBSCAN-SWA
MLEKHLNSTTEITESVPTESFRLFDTILVIDDSLTNLEVLYATLSNLGYEVLVEMDGLSAIEQVKNNPPDLILLDIMMPKIDGFETCRRLQADPETKDIPIIFMTALTDSVEKVKGLKLGAVDYITKPFQQEEVLARIQVHIKLRRLNQELDEQKQQLEERVQARTAELSQTLEELKRTQLQLVHTEKISSLGQLVAGVAHEVNNPIGFISTNLYHANQYANDLINLVKLYQEKFPTPGNEIEEAIETIDLGHISEDLPRLISSMKLGSDRIRGIMQSLRNYSRTDGVEKKAIDIHEGIETTLMILQHRLNAQTYRSGIQIMKSYGNLPMIECYPGQLNQVFMNLLANAIDAIEEQMEGKEYDKGKSRSSDGEEFTPIIYISTSLDREYVSIQIKDNGQGIPESTREKIFQPFFTTKPEGKGTGLGLSICYQIVTEKHGGILDCNSSAETGTEFIIKIPLYHH
>NC_019751|3927849:3988730|3986142_3986790_-|WP_015198930.1|DBSCAN-SWA
MDLGDCYRILGLRTGASFADVKSSYRRLAQLYHPDINPEDRKAKDKFIALTEAYKLLLQVLPATDVVMPQSKATRQATTQQRTATTRKPSGTSPAAAEATTGVAKERVQTKPPNLAEIEQRLKWKTYEQLQRFLQERRFPQAIALAEALAERLPDDAEVRQWQAVAYQVWARALITEKQWLKARIYLKKAMKTDPHNKSLLYEVQCDFQKLEQIF
>NC_019751|3927849:3988730|3970777_3971869_-|WP_015198917.1|DBSCAN-SWA
MTVSLSPATSYRQPWAGLIETYRPYLPVSESTPVVTLLEGNTPLIPAPSLARYIGRGVKVLVKYDGLNPTGSFKDRGMTMAITKAKEAGAKAVICASTGNTSAAAAAYARRGGMKAFVLIPDGYVALGKLAQALLYGAEVLAIQGNFDRALEIVREMSEQYPVTLVNSVNPYRIEGQKTAAFEIVDTLGDAPDWLCIPVGNAGNITAYWMGFCEYHQMGKCDRLPKMMGFQAAGAAPLVYGQPVAHPETIATAIRIGNPASWDKAVAAKSASMGEFNAVTDEEILNAYRILASEEGVFCEPASAASVAGMLKVKDQIPTGATVVCVLTGNGLKDPDTAIKHSGNQFKQGIAPDVLDVAKAMGF
>NC_019751|3927849:3988730|3951736_3955714_-|WP_144051129.1|DBSCAN-SWA
MVLGLDRVEGLPQMLTAVNQVREDFRKHFPFPLVLWINDDVYKQLMQFAPDFESWATSKNFVIQQDELGNHFRDIANLWFSNNLRLGEDDYLVDDYLILKLELEAAQRDLLGDKDFSSSQILDWELEADLECLLGFVNKNINQKDTALEHYQKALSLWRQVDRVENKLADESNESNLHNGNKLERQVKILGEICICYYLKAIKHTDKNHLDWQATKNYIQEYLGLIENNQRLDLINHDSVIFGEILRNLQEWNVLKKIFTQLLETHRAENKPLDLARDYGFLAEAALGEENWRDANSYVRQALDLIKHLSPTPLRRGEGQENTSLTTGSPVSSFPGSSLEMTFSEALPLVRESRQSLGESVPTQSMGMRENLKPLSSQERGLERGLYLCILAKSQYYLGEKSEAISNLETARELSKPLADVRLYLDILNYLQKLYFEQKEYLKAYDIKQEQFSVEQQFGLRAFIGAGRLQSFKGDGFSTENQRNIQHNKYSEKVAPEIAASTRQLDVERLVERVGDTQHKLTVIYGQSGVGKSSLVNAGLEPALKNKAIGIKDNLPVVMRVYTNWQEELAKQIGFEGLGSTIFEKLTEIEQRNIRTVLIFDQFEEFFFVCTEPEQRLEFFGFLADYLNLLSVKVILSLRVDYLHYLLECNKLSSMNIIGNDILSSNVLYELGNFKPDDAKSIIQRLTEGANFPLEAALVDKLVEDLAGSWGEVRPIELQIVGAQLQAENINTLAKYDLLGNQSGEKAKEELVKRYLQAVVKNCGTENMQVAEFLLYSLTDDKGTRPLKTRAELERDLEELVNSSHGLDIHQLNLVVEILVKSGLVLLLPEKTDDRYQLVHDYIAVFIRQQQEPKLKVLMDELEKEREQRKISETKLNKFLKRALTGSIVAGFGLALLSVTAGYQAWEANKQKQQADEQRQQADVNAVEAQLNSSDALFNSGETRDASIAALKVAGTLKQGKGVTTANQMQTTAALREAVHSNYPFTERTTLIGHSDAVNGVAWSADGKTLASASGDKTIKIWDATTIKPLKTLTGHSDRVRGVVWNADGKTLASASSDTTIKLWDATTGKLLKTLTGHSSAVNGVAWSADGKTLASASSDTTIKLWDETTGKPLKTLTGHSDGVISVAWSADGKTLASASLDNTIKLWDATMGKPLKTLAGHSDAVYGVAWSADGKTLASASWDNTIKLWDATTGKPLKTLNGHSDHVYGVAWSADGKTLASASDDKKVILWDLDFNNLVKSACSRLDNYLPFRAEVLGDLKSCQSPSVLARAAEMLVVQGEELARNGDAEAAVTKFQQAQKWNPQLKFDPETKAQEVKDRRTVE
>NC_019751|3927849:3988730|3981355_3982537_-|WP_015198928.1|DBSCAN-SWA
MSKTPTFKTILFTALSITITACTNSTKTSQTIPIGIAFAQTSNVALLGQEGSNGAKIAEKYFNDQGGINGTPIKLIFQDTGGEEQGAINAFQTLINKDKVVGIIGPTLSQQGFSAHPVADRAKVPVVAASNTAKGIPEIGDYVARVSSPASIVAPNSVKAALKQNPNIKKVAVFYAQNDAFNKIETEIFQKTVKDLGLEVVTVQKFQTTDTDFQSQATNGINAKPDLIIVSGLAADGGNLVRQLRELGYKGLIIGGNGLNSSNVLKVCKASCDGLIIAQAYSPQHPGKINKAFRDMYFQQYKVEPPQFSAQAFTAVQVYVEALNELDKKTKISTLQLPKIREDLNKQMLAGKYDTPIGEISFTPIGEIVQKDFYVAQIKMEKDGSAGKFEFIK
>NC_019751|3927849:3988730|3980043_3980994_-|WP_015198927.1|DBSCAN-SWA
MHISIFLQQLLNGLSIGSTYAIFALGYTLVYSILGIINLAHGAVFTLGAYFTYALMGGTFGSSGLLANTTLPFKLPFATALIIGGILSGLVGVAIERFAFLPLRKQGSDALLTVVSSLGVALIVVNLILYMVGAENYTFPSDTYGNLPVSINFGTVENPIPIRTVQIIIFIVSVVIVAMMTWFINRTKYGKAMQAIAEDAMTASLLGINSDRLIVLTFFISSFLAGIAGTLLASSVSIAGPYFGITFGLRGLAVIVLGGLGSIPGAVLGGFVIGIIEAFVPGEYSGYKDAVAFGILFIMLLVRPQGLLGKRFIQKV
>NC_019751|3927849:3988730|3931228_3932860_-|WP_015198893.1|DBSCAN-SWA
MLQAPVNNLVMAKIDLDDYIGKFLNNRYLIRELIGRGGMGRVYLAEDTAKGGLPVALKILSLSLANQQMSQRFAREIFIGAQLGRKSKHIIKVLSYGLTDDKIPFYVMEYLQGTNLKKLIKSSPLDLSEFIKIITQICLGLQCAHQGINLKGEIYPVLHRDIKPENIFIAEDSKVGKVVKILDFGIAKFLTERAGMTLTEAFIGSLPYCSPEHMEGRKLVDVRSDIYSLGVIMYEMLTGIHPFELTSNSFGNWYQAHRFQTPPDFSEIVPQLEIPDSLQRLVLSCLAKDVKNRPHNLRVILDKLEDIQKYLNGEVTHVANNNFTSKSSALQLVPVTEVTEKICLQKTWPRNKPVSPICFPHLLQTNQGSIPTLWAMLPKAEISKLSKQINCTEFIYQPSLYPVILWVTALCDGDFGLTRWLSYFLDLQDSKSQKVAQSLASNGYYHLLFFALEDPTKCQDVMTIMLSAYQRQALMDWLEQSEKTKSLIAIDDSKAILKSHYEKIKPEIIGAIAENNKALKTGMKQWFKKILSRTFNALSRPVF
>NC_019751|3927849:3988730|3970238_3970679_+|WP_041740688.1|DBSCAN-SWA
MGKDLTQEWLGEIQGLKQQLAELQNARNEAWESAEKWRKLYNTEAEQRRTDNQLAQQAIASLNGQLQKIKGIDDKTLPDADTSSAIHAEVIQLQSVEELQTKLIAATKERDRLLLALKTEQEEHAKTRTNLTTALGDAIDGMKQRS
>NC_019751|3927849:3988730|3936623_3937259_+|WP_015198896.1|DBSCAN-SWA
MQQKTISQKIFRIILIALATIGGLGIIGGGVFLYLLGKGFEEETKSTTNISRYKEIFTNFGENAPIIKHFPRTIPTDAKNVKFYFQPGFLQGGTIIRLKMTLPPEKIKSLQAEFRNKAKRKYIPGDIKNSSPQEEVSPQGIRVNFKYDLSLGDDQNSSEKVDNLPKVPSKYEILVIDDTRGAPKYDWNHSDTYGVAINISSSEVIYFADDW
>NC_019751|3927849:3988730|3933981_3935178_+|WP_015198894.1|transposase|DBSCAN-SWA
MFNLTYEFKLKPTQNQITMFEEWLETHRRVYNHALAERKDWYKSRSCRVNACSTHSCYIIPADVPRPTFASQCKSLTAARKESEHLRRVNAQSLQQTLRRLEKAFVSMWEQNHGFPRFKKSGRMRSFSFPQLGVNPLSNGYVKLPVIGAVKVRQSRSIPDGGVIKQACVVKRVSGWYAMLTVQWDVNVPQPLPHGEAVGIDVGLTSFVATSSGLLVKRPRFFVDAERKLKLLQQRVSRKRLGSNNWKKAQKKVAKLHEYIANCRKDWHRKLSHKICDDAGMVFVEDLNLIGLSRGILGKHCLDAGFGQFFNILEQTCFKRDVYFQKVDPRKTSQICPNCGIETGKKELSERTHVCSNCGYTTDRDVAAAQVVAIRGLAAVGHTVKMLAEGKFVGIPVK
>NC_019751|3927849:3988730|3963286_3965668_-|WP_015198913.1|DBSCAN-SWA
MAHSIKKSPASEAEVSKKETQMANLLEKKQNLLSLQSIKHLITNLKVQQKINLGYAIGLGFLISGNLIGLIISDRIYNHANESKLKIQRERKLLIDLQQSTLSLQLVPGFPLSSKKVVNSQDLKNIIIDKIERAKSSFKKLNQTAENSSIKGLKPVLLSYGAIFKSFIENLEAISRKNDFTKFSIRAVEDLSKNQTSLDTQKLINQITIFIQIAEAQQLKAEAELQHTYVLKTIIILLNLVLSVLCIYFISLYLNHAIASPVEALLSNFKRMNHQLNLDLKIKPNNINELIVYTDILNEISQQISDLKKSEKQLKTDAKIANQTQNQFLANMTHELRTPLNGILGYAQILSRSRNLTEEQKHGIHTIYQCGFNLLNMINDILDISKIDNNKIELNSQDFHFPSLIQGLVEFFRLQAEKKGIEFVYKKSDNLPIGLIGDQQRLRQVLVNLLNNAIKFTDTGQITLQVDTSYNLDNVLIHFAVSDTGIGIISEQQEKIFLPFEKLGNSHSQTSGTGLGLAISQTIVRMMGSEIKVQSQLGMGSLFEFAVECPISEDWTESIKNTANGKLIGYSGNPRKILVIDDNWENRSFIVSLLEPLNFIVSEAINGEEGLKKCFDMKPDLIICDLEMPIMSGWEFMTKIRYIEEFKNTIIIISSANRYNYDRDYEKNILAGANDLLLKPIQVEKLYLLLEKNLKLVWKYGDYDFDPYLEQNTYSNESSEILSQVEIIIPPVSDLTTLMKYVKKGQIKGIKQELEKIATKDIKYEAFVKTLNKYVKVLNIQKIRQFLQENIQK
>NC_019751|3927849:3988730|3943933_3947095_+|WP_015198903.1|DBSCAN-SWA
MSNLRAWLAEKTSEEIEHFLGESPRLLLDGGDIHKYCDLLSNYDFIEAKIHHCYFGIQTLIEDYKLIDNTEYANHPECNFEAIESLRIISNALFRSFPVITDDKTQLAGQLSGRLCYFQEQDLIKKLLEQISQTNKTCFRCLTGSLTPPGGSPLIRTLTGHSDGVSAIATSNDGKYVVSGSDDDKTVKIWELSTGKEIRTLSGHSDGVSAIATSNDGKYVVSGSDDKTVKIWELSTGKEIRTLSGHSSRVNAIATSNDGKYVVSGSDDKTVKIWELSAGKEIRTLSGHSSRVNAIATSNDGKYVVSGSDDKTVKIWELSTGKEIRTLSGHSDWVNAIAISNDGKYVVSGSRDKTVKIWEFSTGNFIRTLTGHSDWVSAIALSSDGKYVVSGSGDKTVKIWELSAGKAICTLTGHSDWVSALALSRDRKYIVSGSVDKTVKIWELSAGKEIRTLSGHSSRVNAIATSNDGKYVVSGSDDKTVKIWELSTGKEIRTLSGHSDWVNAIATSNDGKYVVSGSRDKTVKIWEFSTGNVIRTLTGHSSRVNAIALSSDGKYVVSGSTDKTVKIWEFSTGNVIRTLTGHSDWVSAIALSSDGKYVVSGSTDKTVKIWEFSTGNVIRTLTGHSSDVRSIALSNDGRYVVSGSSDNTVKIWELRTGEEIRTLTGHSSWVNAIALSSDGKYVVSGSWDNTVKIWELRTRKEIRTLTGHSNGVSAIALSSDGKYVVSGSGDNTVKIWELRTRKEICTLTGHSDWVSAIATSSDGKYVVSGSSDKTVKIWDFYTGNVIRTLTGHSDSVYAVALSRDGKYVVSGSRDKKLKIWELGTGKQVCTLAGHSDSVMAITLSRDGKYVVSGSRDKKLKIWELGTGKEIRTLTGHSHWVSALALRNDGKYVVSGSRDNTVKIWELETINKRFFNFIWNWIKLRKEIRTLTGHSDSVSAIALSSDGKYVVSGSADNTVKIWEFSTGKEIRTLSGHSDSVNAIATSSDGKYVVSGSSDKTVKIWHFYTGKEIATFTGEGSIGCCAITPDGTTIIAGDASGKVHFLKLENIEVQS
>NC_019751|3927849:3988730|3978820_3979015_-|WP_015198924.1|DBSCAN-SWA
MSKEENIEKILLATAIVVQPKVVPVVTAYIAAKEAEETSKTLYKYSKKASKIAYKGFKKAKKFF
>NC_019751|3927849:3988730|3979411_3979777_+|WP_015198925.1|DBSCAN-SWA
MTNAKNVLGGELEICCTSPMTGFTRNGKCETGINDMGVHVVCAQVTEEFLKFTKLQGNDLSTPAPEYGFPGLKPGDGWCLCATRWQDALKAGVAPPIVLAATHEKLLEYLPLEVLKEHALD
>NC_019751|3927849:3988730|3969169_3969865_-|WP_015198915.1|DBSCAN-SWA
MSAFIFSADGSAAEKITNHPDSIKYLQNSIHPSISSNTKRLLDIFGAVIGLLITACLFIPIACITVISDPGPIFYSQIRCGLNGKTFRIWKFRSMVVNADRLKHLVKNEAQGHIFKCVDDPRITPMGKFLRRTSLDELPQFWNVLKGDMSLVGTRPPTLDEVAKYKPHHWERLRIKPGMTGEWQVNGRSSIKDFETIVKMDINYQQKWSNAYDLMLIFKTIWVVVGKSNAY
>NC_019751|3927849:3988730|3937584_3937983_-|WP_015198898.1|holin|DBSCAN-SWA
MISVFLTVLATALSLLVVDIIFPGVSIANFPAAMIAAVVVGLINGSVKPIFSTLSLPINIVTLGAFSLVVNGFCFWLASVVVPGFAVRGLVAFIAAPVILSLTNTLINNYFVEKNLALNSGGSINKTNLPSN
>NC_019751|3927849:3988730|3988067_3988730_-|WP_015198932.1|protease|DBSCAN-SWA
MDISPIKAVQAAYSGENSYRTPPPDLESLLLKERIVYLGLPLVPAVTELIVAQLLYLQSDDPEKPIKIYINSTGTSGYTGDPVGFETEAFAIYDTMKYIKPPIHTICMGSAMGMAAMLLAAGTKGCRASLPNASIVLHQPKSYAQGQATDIQIRAKEVLANKATMLDIFSRNTGQTKEKIEKDMDRLFYITPHDAVAYGLIDRVFEKNEVANPPLPASIL
>NC_019751|3927849:3988730|3957793_3958711_-|WP_015198909.1|transposase|DBSCAN-SWA
MNMIDAPSLLTIIYVLVDDWYTQHGNRLVPSLPGPQPVFSDSELLTLVLAMDYFPYPGEQQFLGFIRANYLNLFPKLLDQSQFNRRVRRLEGLLEELRRFWVSEMGATFERTLLLDTKPIPVLGYKRSKRQSDFTRSASYGHCASRKMNYFGYKLVVISTLAGVPLVYSLVPAHTDEREAAEVVLQFVRGCNILADKGFIGTQWQAEVSRTTNNRIFTAKRVNQHQQTPAAFERLLNHFRERIEGVFNEVQNTGRNLERLLRKKVDGLCTHVAAKMASHTLRILLRQQFGIDVLTFEQTPVQSYS
>NC_019751|3927849:3988730|3938644_3941590_+|WP_015198899.1|bacteriocin|DBSCAN-SWA
MLQNIHEIQDIPGEKYRFNGNEPILLDDPRAIWVVQSGSFALFAINVKNGTPEGTRRFLFTVKAGEAMFSTPHDTKEEGIRQILAVSLEESELTRVSKTDFETSLASQKRTVINLVERWIHQLGEILESIRTERPSVPDAAIQYMSLAMGEIFQSYPHTVCWIRMQVGRLRWMGIPQLGLEPGDEIMPLGANMWVIAEEIVEFERLHTDTIDDADILLAGVDQVQNYFLRCIDLLEEVEKQQERQRFQERDRLNRQMMTETLGELVEVVRSQPMPVTPDSTAEVTDNYEAVLIAAGAVGKMLGIKIRPPAKSEDMRRVQEPLDAIARASQMRMRRIQLTDDWWQKDCGPMLGYTAEDDRPVALLPTSSTSYEMFDPILRKRLKLTAKRARTLSKCAYVFYRPLPDKENLTTFDLLQFAVRGHYREIFVVLATGVIVTLLGMLTPQVTAILIDDAIPSTNRDLLIQIAGVLIAATFGSTLFQLAQGLAVMRLETYADASTQAAVWDRLLKLKASFFRKYAIGDLQSRVQSISQIRQMLGTTVIKSIFSSVFSLLNLGLLFYYSPTLAFVALLVAFINIAVTVVSGIITLKKVRPQLELQGQIFGVMVQLINGVTKLRVAGAEARAFAYWGKQYTQQLKLTLSTQGVEDIVIVINKILPSLTTAVLFFVATTSIQEAAATGGKGFTTGTFLAFNAAFGIFIGGATSLSTTVIDVLQIVPLWQRAQPILKAEPEVDSNKADPGRLTGRLNVEHAIFRYRDDGPLTLDDVSVYANPGEFIAFVGTSGSGKSTLFRLLLGFDVPESGSIYYDGQDLAGLDINAVRRQLGVVMQNSRLTSASIYENIACGALVSMEECWEAAKMAGFAEDVQSMPMQMHTVISEGGGNISGGQRQRLLIARALVLKPRILLFDEATSALDNRTQAIVSESLERLQVTRIAIAHRLSTIRKADRIYVFENGRITQHGSFEELAQQKGLFAQLMARQSL
>NC_019751|3927849:3988730|3984786_3985125_-|WP_041739691.1|DBSCAN-SWA
MINLVMIGGGHSHTIALRFFATNPVPGLHLTLISDAEDTPYSGMLPGHIAGFYSRSQCHINLRRLTISAQAEFYVERVVNLDLEKKLVICENILPIAFDIVSIDIGSKLKRI
>NC_019751|3927849:3988730|3985249_3985861_+|WP_015198929.1|DBSCAN-SWA
MLKQTLQRQIKQLNSQEIQERLLAINQLEQITKTHPSHHWYIMEALSNFLRQSAPIDNLDIICIDIQTALHVICNRNVQHDPKNQILDLSFTNIPNVNLDNTNLQQINFYQSNLTNASLKNANLHQAILAAANLKGANLERANLSSANLGAANLTNANLRAANLHRANLYLANLEGAIVQEANLWEANLREANFKGVRQPLNS
>NC_019751|3927849:3988730|3947091_3948117_+|WP_015198904.1|DBSCAN-SWA
MNTPPQLDFQFQKIILEKSHNFTNCEFIFTAINDFLHKYNRGYFTIIGSPGSGKSAILAQFASFNPHSNINIIYYNAQIENKNIAEEFLKYVCSQLIEKFHNSLITPPQPSPLAGREQDSNFLPYKEKQRGQDSNFPPYTGGQRGVLPDNATEGSWFLSLLLQQISDELAPNQKLIIAIDALDTINPNNQPPGTNLLYLPRYLPPGIYFLLTRRPFKTEKSGLLIEAPSQILDLSQHDLKNWDDEQAFTQHWQQMQGEGFSDIAMKILQVLATPENEGISASTILQRIHQTNPPTLDADIFDVEEVLENWFEFLQQHQVNKEIRYSLYHPNFRNWLAEKLS
>NC_019751|3927849:3988730|3973364_3973652_-|WP_015198920.1|DBSCAN-SWA
MLDLREIYPLSDFQRNARQFIEQLQENQKPIVLTVNGKASVVLQDAASYQKLLDDLELAKSAATIRQSIAEVAAGQEQDAIEALEALRAKHDIPR
>NC_019751|3927849:3988730|3956398_3957745_-|WP_015198908.1|DBSCAN-SWA
MAIDLRRFFEATDPSKTLVVNQPEDRKYYIDFSSVRGGDVITKLKQKITYFKPNDPTCQLFTGHIGCGKSTELLRLLVELEKDGFHVIYFESSEDLEMTDVDIGDVLLAIARRVSQSLEKINIAEPRKLKELLQGAWNVLNSEVTGVKLKVPHVGDVGFSAEKEKYSLSLGIGEITSKAKSDSTLRERLNQYLAPQKVKLLAAINQELLEPAIIQLKQQGKKGLVVIVDNLDRIDNRVKPWGRTQQEYLFVDQAESLNKLSCHVVYTMPLSLKFSNDYGMLTQRFDDPKVLPMVPVKLPDGSIHEQGMALMRDMVMARAFPDLNSVDRLSKISEIFDNEMTLDRLCIASGGHVRDLLKLLNTCIQEEMTLPLTRGTLETVIVGRRNEMVLPISDEEWELLHRVKEKKKVSDDMGYQKLIRSRFVFEYRDNGEFWFDVNPILAEARELQ
>NC_019751|3927849:3988730|3972519_3972882_+|WP_015198919.1|DBSCAN-SWA
MIEGNFDDIGHIFFEIDLITTDGLNLPVDAMLDTGFTGFLVINKQDLEVLEWVYRGDEQMLTARGEAIFEKYLGKVFLDEQEYEIPVYAGDEITEVLIGSAWLKILPLVVNYQAGILTLG
>NC_019751|3927849:3988730|3935217_3936405_-|WP_015198895.1|DBSCAN-SWA
MQLIKKNNIWKKIIYFCLPIILIGLFFANFTSPSVEIVGADFIGEAVLKTGTLFQNTQVGGLSGITYDASNQVYYAISDDRGDKAPARFYTLKIDLSKGKLQQGGVVPVGVTLLLDAQGKNFASTTTDTEGIALTQKGDIYVSSEGDVGKSINPFIKEFTLASGKEVKTLPVPEKFLPTSSKRGIRNNLGFESLTVTPDHQFLYTATENALVQDGSEAKPNTSSPCRILQYNLATNQAEKEFLYPTEAAPATIKIINKYANGLPDLVALDNQGNLLSLERAFTGFGFSVKLFKVSLEGATDIRNIDSLLATDIANIQPVRKQLLLDLGKENVLLDNIEGLTLGSQLADGQPSLILISDNNFNKLQRTQILALRLKTESSSPILRFFRQLVPNSNK
>NC_019751|3927849:3988730|3950563_3951610_+|WP_015198906.1|DBSCAN-SWA
MADKLSLMDSYDEFLRELKERIRSAQIKAALSVNRELVLLYWQIGREIIIRQQQQGWGAKVIERLAQDLKAAFPDMKGFSARNLKYMRAFTEAYPDEQIVQQVVALIPWGHNVRILDAVKDFSVRLWYVQKTIENGWSRNILVHQMESGLYHRQGKATTNFENTLPKPQSELAQQLLKDPYNFDFLSLGKEAQERDLEKALIEHIRDFLLELGVGFAFVGSQYHLEVGNQDFYIDLLFYHLHLRCYVVIDLKIEDFKPEFSGKMSFYVSAVDDLLRHPDDKPTIGMILCKTKNQTIVEYALREMNKPIGVSTYQLRDILPEQLQGSLPTIKQLEAELEALSVDVEDEE
>NC_019751|3927849:3988730|3937335_3937530_-|WP_015198897.1|DBSCAN-SWA
MKVLRYILAILIPPLGIFLTYGIGQTLIISVLLTLLGWVPGSIHAVWAISKRDEAISLGQRETT
>NC_019751|3927849:3988730|3960194_3961838_+|WP_015198911.1|DBSCAN-SWA
MGQSLRVIQVMASFWGALTAVLLCGLNTSVQAAETVVIRFGEFAESISLAELQTMATTGKFPDGYGIYTKRLSEQQRTQIIGALRTEIPVGVVTMNRLLNTPVGTTILNDLSKAIIRKDASGVQAIRAGLVLGATAPQGLSVLNFIAAYPGKRLEIDLTQAFQVGKNLNVAFWQTQRFMEALAPRLQPRKIDLSLPFDPSQPGTSQVKVININFDDTKRQRRIPIDLYWSDAVTPNRPVILFTHGLGSVRTELRYLAEHLASHGYAVAAFEHPGSNGVNLEEALAGKTRLMKPAEFLERPKDISAVLNQLEILNQTPSSPIKGKLATNKALVLGYSFGGSTALVSGGAEYQLEYLKQRCKENLATASLGEGIQCIAQELPENTYQLRDERVKSIIALSPTTSLLFGNTGLSKITIPTLMWSASVDKTTPALTEQIISFSRMQQPKLLAGVIGATHLSVKDPSATMDQRGKINTPLSGGEVVDTQAADIRKYLKAIVVAFAAQLTPEAEKYSIFLTSDYAQYASTNDFPIRLIREIPPDAMKVLEEMK
>NC_019751|3927849:3988730|3974065_3974251_+|WP_015198921.1|DBSCAN-SWA
MTTSSVTTRDLHSTFVSKTNKAYYREDQQDKFMHLQAEVDYLLQQLQNLKQEKSGTDTCEN

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015198891.1|3927849_3929304_-|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_144051128.1|3929576_3931037_-	protein kinase	A0A1D6Y713	Golden_Marseillevirus	2.1e-12	29.3
WP_015198893.1|3931228_3932860_-	serine/threonine protein kinase	Q67624	IC4_retrovirus	4.4e-19	29.3
WP_015198894.1|3933981_3935178_+|transposase	transposase	A0A1L2BWU7	Bacteriophage	2.0e-85	46.2
WP_015198895.1|3935217_3936405_-	esterase-like activity of phytase family protein	NA	NA	NA	NA
WP_015198896.1|3936623_3937259_+	hypothetical protein	NA	NA	NA	NA
WP_015198897.1|3937335_3937530_-	YqaE/Pmp3 family membrane protein	NA	NA	NA	NA
WP_015198898.1|3937584_3937983_-|holin	phage holin family protein	NA	NA	NA	NA
WP_015198899.1|3938644_3941590_+|bacteriocin	NHLP bacteriocin export ABC transporter permease/ATPase subunit	W8CYL7	Bacillus_phage	4.0e-23	25.2
WP_015198900.1|3941567_3941876_-	hypothetical protein	NA	NA	NA	NA
WP_015198901.1|3942041_3942335_-	hypothetical protein	NA	NA	NA	NA
WP_015198902.1|3942560_3943937_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015198903.1|3943933_3947095_+	[myosin heavy-chain] kinase	NA	NA	NA	NA
WP_015198904.1|3947091_3948117_+	hypothetical protein	NA	NA	NA	NA
WP_015198905.1|3948368_3950276_+	glutamine--fructose-6-phosphate transaminase (isomerizing)	A7IW18	Paramecium_bursaria_Chlorella_virus	5.5e-106	38.3
WP_015198906.1|3950563_3951610_+	DUF1016 domain-containing protein	Q9JMP5	Wolbachia_phage	5.5e-116	58.3
WP_144051129.1|3951736_3955714_-	hypothetical protein	NA	NA	NA	NA
WP_015198908.1|3956398_3957745_-	AAA family ATPase	NA	NA	NA	NA
WP_015198909.1|3957793_3958711_-|transposase	IS982 family transposase	NA	NA	NA	NA
WP_015198910.1|3958972_3959989_+	sulfate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	7.9e-27	34.1
WP_015198911.1|3960194_3961838_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_015198912.1|3961846_3963238_-	hybrid sensor histidine kinase/response regulator	NA	NA	NA	NA
WP_015198913.1|3963286_3965668_-	response regulator	A0A1V0SGX0	Hokovirus	1.2e-46	32.5
WP_015198914.1|3966383_3968354_-	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	1.4e-93	40.9
WP_015198915.1|3969169_3969865_-	sugar transferase	NA	NA	NA	NA
WP_041740688.1|3970238_3970679_+	hypothetical protein	NA	NA	NA	NA
WP_015198917.1|3970777_3971869_-	threonine synthase	NA	NA	NA	NA
WP_015198918.1|3972205_3972523_+	hypothetical protein	NA	NA	NA	NA
WP_015198919.1|3972519_3972882_+	hypothetical protein	NA	NA	NA	NA
WP_083866321.1|3973036_3973318_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_015198920.1|3973364_3973652_-	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_015198921.1|3974065_3974251_+	hypothetical protein	NA	NA	NA	NA
WP_015198922.1|3974278_3976543_-	hypothetical protein	NA	NA	NA	NA
WP_083866374.1|3976974_3978483_+	iron uptake porin	Q5GQG9	Synechococcus_phage	3.1e-11	39.8
WP_015198924.1|3978820_3979015_-	hypothetical protein	NA	NA	NA	NA
WP_015198925.1|3979411_3979777_+	DUF2237 domain-containing protein	NA	NA	NA	NA
WP_015198927.1|3980043_3980994_-	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_015198928.1|3981355_3982537_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_051036686.1|3982797_3983505_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_041739691.1|3984786_3985125_-	hypothetical protein	NA	NA	NA	NA
WP_015198929.1|3985249_3985861_+	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_015198930.1|3986142_3986790_-	J domain-containing protein	NA	NA	NA	NA
WP_015198931.1|3987351_3987948_-|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	1.3e-45	49.0
WP_015198932.1|3988067_3988730_-|protease	ATP-dependent Clp protease proteolytic subunit	G3M9Z8	Bacillus_virus	2.9e-22	37.3

3. NC_019728

CRISPR-Cas detection and classification

Crispr_ID: NC_019728_1

• CRISPR_ID: NC_019728_1
• CRISPR_location: 12168-12275
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_019728_1

Consensus_repeat	Method
AATTTTCAATCTCCACTTTAAAAT	CRISPRCasFinder

spacers of NC_019728_1

>1.1|12192|60|NC_019728|CRISPRCasFinder
GCTTTTGCTGATCTTGCAATTTTTTTAGCTCATTTTCATCTACAGAATTTTTATTCTTTA

CRISPR arrays and Neighbor proteins around NC_019728_1

CRISPR arrays

The CRISPR arrays of NC_019728_1

>merge|NC_019728|1|12168-12275|CRISPRCasFinder
AATTTTCAATCTCCACTTTAAAATGCTTTTGCTGATCTTGCAATTTTTTTAGCTCATTTTCATCTACAGAATTTTTATTCTTTAAATTTTCAATCTCTACTTTAAAAT

>NC_019728|1|1|12168-12275|CRISPRCasFinder
AATTTTCAATCTCCACTTTAAAAT	GCTTTTGCTGATCTTGCAATTTTTTTAGCTCATTTTCATCTACAGAATTTTTATTCTTTA
AATTTTCAATCTCTACTTTAAAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_019728.1|WP_015173954.1|22321_24562_-|hypothetical-protein	unknown	unknown	gnl|CDD|366045
NC_019728.1|WP_015173951.1|15770_17330_-|Hsp70-family-protein	unknown	unknown	gnl|CDD|212667
NC_019728.1|WP_041741238.1|27235_27460_+|hypothetical-protein	unknown	unknown	unknown
NC_019728.1|WP_015173959.1|28207_28810_+|hypothetical-protein	unknown	unknown	unknown
NC_019728.1|WP_041741257.1|28823_29084_+|hypothetical-protein	unknown	unknown	unknown
NC_019728.1|WP_041741245.1|11147_11762_-|radical-SAM-protein	unknown	unknown	gnl|CDD|379137
NC_019728.1|WP_015173946.1|6630_9177_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|163057
NC_019728.1|WP_015173945.1|5808_6627_-|hypothetical-protein	unknown	unknown	gnl|CDD|224117
NC_019728.1|WP_015173943.1|3321_4320_+|hypothetical-protein	unknown	unknown	unknown
NC_019728.1|WP_015173955.1|24680_25298_-|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|238734
NC_019728.1|WP_015173947.1|9193_10678_-|hypothetical-protein	unknown	unknown	gnl|CDD|274008
NC_019728.1|WP_083866414.1|25885_26290_-|site-specific-integrase	unknown	unknown	gnl|CDD|271175
NC_019728.1|WP_015173944.1|4312_5773_+|hypothetical-protein	unknown	unknown	gnl|CDD|372045
NC_019728.1|WP_015173961.1|29259_29706_+|hypothetical-protein	unknown	unknown	unknown
NC_019728.1|WP_015173941.1|1025_2153_+|hypothetical-protein	unknown	unknown	unknown
NC_019728.1|WP_015173953.1|19144_19909_-|ParA-family-protein	unknown	unknown	gnl|CDD|379293
NC_019728.1|WP_144051170.1|17825_18773_-|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|275105
NC_019728.1|WP_015173940.1|102_987_+|GTPase-domain-containing-protein	unknown	unknown	gnl|CDD|206648

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_019728.1|WP_015173954.1|22321_24562_-|hypothetical-protein	gnl|CDD|366045	pfam00350, Dynamin_N, Dynamin family.	3.08417e-10
NC_019728.1|WP_015173951.1|15770_17330_-|Hsp70-family-protein	gnl|CDD|212667	cd10170, HSP70_NBD, Nucleotide-binding domain of the HSP70 family. HSP70 (70-kDa heat shock protein) family chaperones assist in protein folding and assembly and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). Some HSP70 family members are not chaperones but instead, function as NEFs to remove ADP from their HSP70 chaperone partners during the ATP hydrolysis cycle, some may function as both chaperones and NEFs.	8.57268e-22
NC_019728.1|WP_041741245.1|11147_11762_-|radical-SAM-protein	gnl|CDD|379137	pfam13353, Fer4_12, 4Fe-4S single cluster domain. This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	3.04699e-40
NC_019728.1|WP_015173946.1|6630_9177_-|AAA-family-ATPase	gnl|CDD|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	1.46428e-73
NC_019728.1|WP_015173945.1|5808_6627_-|hypothetical-protein	gnl|CDD|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	3.16331e-14
NC_019728.1|WP_015173955.1|24680_25298_-|VWA-domain-containing-protein	gnl|CDD|238734	cd01457, vWA_ORF176_type, VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. The members of this subgroup are Eubacterial in origin and have a conserved MIDAS motif. Not much is known about the biochemistry of these.	2.73517e-76
NC_019728.1|WP_015173947.1|9193_10678_-|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.000570858
NC_019728.1|WP_083866414.1|25885_26290_-|site-specific-integrase	gnl|CDD|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.15412e-17
NC_019728.1|WP_015173944.1|4312_5773_+|hypothetical-protein	gnl|CDD|372045	pfam12325, TMF_TATA_bd, TATA element modulatory factor 1 TATA binding. This is the C-terminal conserved coiled coil region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes. The proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMF1_TATA_bd is the most conserved part of the TMFs. TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal and plant cells. The Rab6-binding domain appears to be the same region as this C-terminal family.	0.00983423
NC_019728.1|WP_015173953.1|19144_19909_-|ParA-family-protein	gnl|CDD|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	1.09831e-68
NC_019728.1|WP_144051170.1|17825_18773_-|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	1.45394e-43
NC_019728.1|WP_015173940.1|102_987_+|GTPase-domain-containing-protein	gnl|CDD|206648	cd00882, Ras_like_GTPase, Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases). Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.	4.74077e-06

Protein sequences

>NC_019728.1|WP_041741245.1|11147_11762_-|radical-SAM-protein
MSLLNIAEICTATQTLGPGQRFAIWVQGCCFNCQNCISPDWIPMITGNLMEPKLLANMVLSTPNTEGITVSGGEPMLQAEALFELFTFLRQEQDISIICFTGFTLEQLRSKCDRNIEQVLNMIDVLIDGQYVSELNDNKGWRGSSNQVVHFLTSRYLSQANLFLERERNVEIHLRNEAALMIGIPPHNFQRAFEETIENLRGCL
>NC_019728.1|WP_015173947.1|9193_10678_-|hypothetical-protein
MSGEKRRYVNVEEQELRRLRKQDSRLRSLNQDLPERLNAIREEANRELQQRLAPMEHRALQQEQEAKKLKSNLAILELQTHQRLQQQRKEFQKVIRDSESKQQQALEVEVKRLEDAMREGFAEQRSLFLQITAEQRQEYLALNQHLDQKFTELIDEERQAREQLQQQLEQEKQDKATLAQNILDDVQTIWEQIDCNYQHQRFAPGKLNDLKREINLARDNIQNGVLEAAIATSQQTYFKLADLRLELELKQQEWELLYNSALEDLKSLIAEVQANREYEIEIGQGDESQKFRLEVDYWTNGSLKKYEQELQEIETSLQKSESSLTTEQIREIVQQIEELQPCLEEIVEQAQREILSSQLRAEIADKVAHVLARMGYVLIDPNADSIYEEDDQRKAYVLKLKDANGGEVVTIVSPDKEFGKNLVSINSFGRILRDENAQKENAEAIFDALESQGIETQGSTECVEQPRDDIETLFEDALQQQVKKTEQVNKTSQK
>NC_019728.1|WP_015173946.1|6630_9177_-|AAA-family-ATPase
MTVERVTAGLNLEAGDRFIILYGANTSDQFCTPELLLRDIEWVLHRYLKSQGYQRILFFDGHRKLYFLDRESRDRCLPRRASTNPLPPKNSEMMVKPGPLGRKKRLLPNRSEPVAPTPAVSVASPPQAPSLMRDITVIPYFHTAMVEMEQLSAIVFSYAEGLANFANQQELFGRIIEWSRLPANNRNRCIFIFHYENRNGLEEFCRRHRFTYLENLLLNREQAGQSLNICRLGAPIADEIEYLIHYFRLDKEKPVDWGTIQLLSRWIAAENRQLNYWYDCFAIAKEISLAEARKQKWLSGNVSSKPGLERLQKMIGLQSVKEVVKQRAEVLKVENIRQQQGLFTEPPRLHLVFKGNPGTGKTTVARLIGEIYRDLGLLRRGHVVEVARQDLVAGYLGQTAMKTDSVIDSAVDGVLFIDEAYNLNQGPNDSFGLETINTLLKRMEDDKHRLAVIIAGYPDRISEFINSNPGLERRFRKEVLFEDYKPEELMEIFHQQISQIQGVIAPQLETALINLFTRLYEERDDKFGNAGLVQNLFQSMDELRAQRIAQNNLDFLHEPLQLDDLPAKEREISQQGVKDKDNLQQLRQKLDNMIGLLNVKQRVNELINTERANQRLKAEGYDSFSTLETRHLLFLGNPGTGKTTVARIVGEIFKALGLLKKGHFVEVGYSDLVAEYVGQTAPKIKKVIESALDGVLFIDEAYSLAESSFGLEAIDTLVPMMENQRHRLVVILAGYSLEMENFLNANSGISSRINDQIEFPDYNGTELFRIFMELCTQNKIKCPDNVANKLRETFNRMYATRNRKFGNGREVRNFYERMVRQWKNRISREHLTGEAMLTFAISDIPSLN
>NC_019728.1|WP_015173945.1|5808_6627_-|hypothetical-protein
MNNCPVCNSEYTQGEVICPICSWDLTPYPLTFAGQIPDEYISKEKTKLNWAREIWIKLHHLPSLSQAEIVELQNEKIRLEKSLQQLQSQFAQEKSHLESQINILNNDKRDLSTKVLSLEQEKSQFQSQAETISKEKIKIEQERSHLQSQVAQITQENECLLQRIATYEQERSQFQSNLESLKQQQNNLLDNIKKLENEKSELQHQANRLQIQLKAELSQAEVKLINVEQERNQLQGQLQEVQAELDKANEDRERLRQRLSSSKPGKDDVWDL
>NC_019728.1|WP_015173944.1|4312_5773_+|hypothetical-protein
MFEETSDIVLDTQTPVSKWAPIVYGRTYAVDFRFLVIPDNFDDNLKDLLWQYIKVTTREAENLSGNPRWIFIRGKKRCVVGVTCMVRDLIGFQADNTPEDLTRDKLGRPLYTFVGYVSQDPMITAVPAMNLELFAEPYKEFVPKKWQEIYADLGSNQAATQELKSQYEREFNLEEVATEDLEAKKISIENLLTSGQNSIIFWNISNTRNIWFTASTNREPLSICFGNFNKRDLINSVYMNAAIDEKEGREEVEKVKKVSKTQLNSQFENSTYTQSPSQRFNEQVHSSSQSDEQWDSEYLGIEDDIYQTDKEEMSFIVSISKPGYEFTRKALGEGIANGLSFINRNTVGKIAEIRYGKENVNKMHEQIIGVDELVTELKKTIEKLEKLQKQRETLIAENREAELHKLNESIESLKKQKKDLKQELDDIEENSRSRRTNQSIQPRQTEKRAKTNPNLGFQDKEIMENKQIDSDTNAKKSSQSKDIWEL
>NC_019728.1|WP_015173943.1|3321_4320_+|hypothetical-protein
MVAEAKITMLGLEGSGKTCYMLGLYATMQMGLQGFTLTATDMDEDLRLTSLWERMVDEEGENRWPFPTGVESHQYEFDFSYGMRPLIKFDWLDYRGGDMKGFSTQEGVQILTKRLLESSCVFLCISGEYLKQEVSSDMELMSLAKKTGVDRMNKFLMDISKNLKECQRPFPIVIVITKFDQCYERAKDKVSKEKLFDDIKKMFNALFLPNKDWLVMLCPVTLGKGLENDGVTGEIQPKNLHLPLLFALYAKFREYAMTEQARVNETQIRLDILRSGNWFQRFFTGDDQRVAESSLENYQNHLQEIQQRMALLAQELTNAQIFLGGKEQQVDV
>NC_019728.1|WP_015173941.1|1025_2153_+|hypothetical-protein
MSRWAAIVYGRTYEVDFRFLALPHDFNGAEQNWAMMHIQTMTRLPEDLPGKPRWAVFTNDKLCVIGVACMARELGGQANTNNEDITRDQRKRPLYTFVGYATRLNDQDVVEIPNYLGQDLSLFSLPYHQYVYPNWRVKSYDERSSVAIATTYQPLSYPTIVIPADLEKRDFSLNLAEDDAIYLWRDDDEKRHYLWASAAKQISEVNNNVSLCLGLMRSSATNGAFLNVTIADVAHKEKIIRVLESTSAPSVDSTSVAVLSQPTPKLRNVGDVRDKTSLILQQVSALLIGAITGFLVARLLKLGAAKVVIYTFVGGIVTWILLLIALGVNLLIKRTSSQKLKNNESSVLSKQDRMFGFRDKTEQDETKDDDFMGWR
>NC_019728.1|WP_015173940.1|102_987_+|GTPase-domain-containing-protein
MRIVEIGHEGVGKTTFMASMYGTLQKSIEGFSLRASHVNDHNRLIKLSTDIKQKKYPTPTDQRQEYKFYLQYQNKDIFPFTWADYRGGAIRETQDSEQATLLQKDLQQADGILIFCDCQALVQRDSRKNQIGRMTALITNALKNIERPIGLAVVLTKADLVNELNEDDFKIFEGLSKAIKASTYIASMMIPVACGPEPINVELPLLFVLYIGVFIQANYLTKEINEHKQMAEYYEKQTYGFGGFVQELWDIFQGNTTYREMSQESLEKATTKYKELEPLIEPVEALKKYLSISE
>NC_019728.1|WP_015173951.1|15770_17330_-|Hsp70-family-protein
MSSHKVGLDFGTANSVVSYFENGTLHLFEYEFKNGQKHIPSLIVYDGDGIVIGDAARSKIIRDPNVEGYGRFQKQLLFHTSKYLNSDQEQRARITVTADFLRELLFSKEVQSSSFSQQKGNIKNLVISIPETYYRDIANQEKVCLNRLIMNELGIGANNFQLISESVAAATYWIWEKQRQNLETHGNLLVCNMGSSSFNLSLCSISTTEKVKVLYSDNYGDAGFDFDRQCVQLAYTEKHGHFLAEESREFIRLLKDFELKKVNSHQESTSRLITYLKMPEAMAEYNLYCFGGGYAVKCQHISEAFAPIQKGIQEVIQHLYIWMQSHQQSFDFLFIIGDLCQFILTQNTILQALDIQESDPRFDPSFNNAYSSFAISHGACLIANSLIDPVERCVYTLGIVAENLNANAERERQLIPIIQGGTDLDDLLETQFLDQPLLTAFTGNFSTITVWVDAHLQGDIFREVKLDAIKLPNYSCRNHWRVGMRVNHSHIFYLVIEDCKNKQRLEYELGILSNIVAQL
>NC_019728.1|WP_144051170.1|17825_18773_-|ParB/RepB/Spo0J-family-partition-protein
MVSDPPEVIATSEALTPTQLNSVVEDKSAGIGEGETLPIAKIKLPASQPRRYFDPKKLEELSRSIKQFGVLEPLLVRPLNNDNFELIAGERRLRASELAGLMEVPVVVKEMDDYTTQQVRLVENLQREDLNPLEETEGILELLGIQLQQPINDVVSLLYRMQNEAKGKITQNVLGKHETLAVQSVFDVLGTITWESFVNSRLPLLKLPEDVLSVLRQGKLEYTKAVAIARVKDDEQRAELLDKAVIENLSLSQVKELIQQLQANGTQEILPEKALSQRYADIGKQLKQAKVWDDAKKLIKVEKLLSDIEKILSGG
>NC_019728.1|WP_015173953.1|19144_19909_-|ParA-family-protein
MSQTHIIALFNQSGGVAKTTLTQNLGYHLSQKKNTRVLLVDMDPQASLTMFMGLEPDELETSIYNAIVNNKPLPIYPESINGLSLVPADINLAAAEMQLSGAMSREYRLKNALAPVLDDYDFILIDCPPSLGLLSIISLTAATHILVPIQCQFKSFKGTELLLNTVAQVRSHTNPNLQFAGFVPTMYDGRTAQESRTVKAVQEQLSPLATVFPPVPKSIAFADASERRVPLALLDKSHSAVAILKKIALQLEKL
>NC_019728.1|WP_015173954.1|22321_24562_-|hypothetical-protein
MENLNEIKNRMMSQQSVDSEKNKVESAKREYSDSNTLNVEYIDNQTTNWIVISQFKKFFNAYHDVEPYIKIDETTKSHIENKNGWISRLEQEEFPVAFLGSFSAGKSTIINAIFKREILPEAVNSTTAFPTIIRKGEKDIANIYYIDEDAKNQLCNELCTQIRKKIDKDIFNENIVLTSQEIRNKLLEKLKKDISEYENKIGNKIESKPLETLQKLFDGWGKYQSATKIIAIDALTHYVEGHEEALFIDRIEVAIKNINIPDHVVLVDLPGLAVANERHIKFTKEYVQHKAKAFVVCMKPKSLLEGEEIKFLEEINRVNPTILQRSFWVINQWETLNDHQKKEEDANFYKKIKDYSFNITDNRFFKFTALNYFYLSCMADETLSETKKLKEQKSSYLRSLTSNGLDDLSKEEIKNLLNYDEIKSFLNFVDSLFNYLGTVAQDEFIKNAKSELLQEVLRLQKLLIPDYTMYGKKDNFEIEIQSVEVDKQVNAFIGNLEGKVERFGIQMRNVGKIDFWKESNTIQIEQEISRIILQLSRDVTNKLRSGYDNDGLLSRLPSEVIDKLELTFLMRDKLVVAVEEFFLNSLGRLLLELKEVNKDYLPESLLKLLEDKLGKRDIEMRLKGLADALFFQYGDEIERISFSLNECQGATFEERVGSALEKYKNELKKFIRSLVDDLNKYVRRSVKNHTQYVEQELLKLFVDERERIVIQIANKINLSEVTVFEQQKKSIISNSYNILTDLKRQL
>NC_019728.1|WP_015173955.1|24680_25298_-|VWA-domain-containing-protein
MLENRDYTLIIDKSGSMSKKDQEGNKSRWNLMEESTFALASKCEEFDPDGITIYTFSRNFKRYDNVNSSKVEQIFSENEPKGNTALAEVLQDALQNYLQRKIKPENKRDGETILVVTDGKPDDQEKVAKVIIQATQDIEKEKELAICFIQIGNEKEAADFLNFLDDELKSMGAKYDIVTTVSLLDIENEELTFKEVLLRAIDPNS
>NC_019728.1|WP_083866414.1|25885_26290_-|site-specific-integrase
MADRNRGYYTIKFRGKGGKYREIGLDHETSRAFKKYRGMAGDRMPVFANVSRNPTKRGLPLSDRAIKRMIQDISEAAKVKFSCHWLRHSHATRAIEHKNVFEVQNQLGHSKSDTTKAYVRAKKDAGTGTVLPRF
>NC_019728.1|WP_041741238.1|27235_27460_+|hypothetical-protein
MNLQEIINSINSLPTEERDYLFEFLRNKKEESRGDNFWQGLQKFRKVIQNEGIIFTDEDFADLRDTSVGREIDL
>NC_019728.1|WP_015173959.1|28207_28810_+|hypothetical-protein
MSDENKPSQMLRVPTPLIDAVRELSRLHRQGKTSEVLSGLDDLIFTLEFSSASPKNSAPQAILEICSRLDNLESQFSGSSNNNEVSSTKRLNDLEQKIDSINNRLTQFAEAIMLLQSNINNQPRRSKSYNSNSYYKGQSVKFQPITEESLASRLGVTPESLRKERESQPAPLFFAWSKRKDTSGIGWEFNDKTNLYHPIT
>NC_019728.1|WP_041741257.1|28823_29084_+|hypothetical-protein
MKTDQERQELIQDIIVLLYQAYDSTLDNIHALLKRIDDMEDEEDLQAIQEAREDIRINGTVSWNEIKEEIRNESKKSDLISTSISI
>NC_019728.1|WP_015173961.1|29259_29706_+|hypothetical-protein
MIPEFDSNGNLPPGVYFCEWQEFKERFGKTRRRVLLMAGLEMAMQELKTAGCRVIYINGSFVTSEPNPGDFDACYDDETVDIENLRINAPRLLNHYDRAGQKAKYKGEIFPSNQPVGSYGDNSFNFFQCDRRGNKKGIIAIDLMRWEP

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_019728_1	1.1|12192|60|NC_019728|CRISPRCasFinder	12192-12251	60	NC_019728	Calothrix sp. PCC 6303 plasmid pCAL6303.02, complete sequence	12192-12251	0	1.0

1. spacer 1.1|12192|60|NC_019728|CRISPRCasFinder matches to NC_019728 (Calothrix sp. PCC 6303 plasmid pCAL6303.02, complete sequence) position: , mismatch: 0, identity: 1.0

gcttttgctgatcttgcaatttttttagctcattttcatctacagaatttttattcttta	CRISPR spacer
gcttttgctgatcttgcaatttttttagctcattttcatctacagaatttttattcttta	Protospacer
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