CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_019733	Crinalium epipsammum PCC 9333 plasmid pCRI9333.01, complete sequence	0 crisprs	NA	0	0	0	0
NC_019734	Crinalium epipsammum PCC 9333 plasmid pCRI9333.02, complete sequence	0 crisprs	NA	0	0	0	0
NC_019755	Crinalium epipsammum PCC 9333 plasmid pCRI9333.06, complete sequence	0 crisprs	NA	0	0	0	0
NC_019754	Crinalium epipsammum PCC 9333 plasmid pCRI9333.03, complete sequence	0 crisprs	NA	0	0	0	0
NC_019737	Crinalium epipsammum PCC 9333 plasmid pCRI9333.07, complete sequence	0 crisprs	NA	0	0	0	0
NC_019756	Crinalium epipsammum PCC 9333 plasmid pCRI9333.08, complete sequence	0 crisprs	NA	0	0	0	0
NC_019753	Crinalium epipsammum PCC 9333, complete genome	20 crisprs	PD-DExK,cas14j,Cas9_archaeal,csx3,cas10,csm3gr7,csx19,csm6,cas6,WYL,RT,cas1,cas2,cas3,cas10d,csc2gr7,csc1gr5,cas4,c2c9_V-U4,DinG,csa3,cas14k,c2c5_V-U5,Cas14c_CAS-V-F,2OG_CAS,Cas14u_CAS-V	2	18	9	1
NC_019735	Crinalium epipsammum PCC 9333 plasmid pCRI9333.04, complete sequence	0 crisprs	RT	0	0	0	0
NC_019736	Crinalium epipsammum PCC 9333 plasmid pCRI9333.05, complete sequence	0 crisprs	NA	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_019753_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_1

327814-327958

TypeV

Consensus_repeat	Method
TTTTCAGTATACAACTTTATTGTCT	PILER-CR

2 spacers

The CRISPR arrays of NC_019753_1

>merge|NC_019753|1|327814-327958|PILER-CR
TTCAGTATACAACTTTATTGTCAAAAATTCGGCGTAAATTTTGACGCTATGGCTTTCCAGTATACGACTTTATTGTCTTGATCAATTTCATTCTCTACCTAAAATCAAGGGTTCTGAGCTTTTTTAGGATACAACTTTATTGTCT

>NC_019753|1|1|327814-327958|PILER-CR
TTCAGTATACAACTTTATTGTCAAA	AATTCGGCGTAAATTTTGACGCTATGGCTT
TCCAGTATACGACTTTATTGTCTTG	ATCAATTTCATTCTCTACCTAAAATCAAGGGTTCTGAGCTTT
TTTAGGATACAACTTTATTGTCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_041225819.1\|328100_328412_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379453
NC_019753.1\|WP_015201398.1\|322248_323055_+\|heteromeric-transposase-endonuclease-subunit-TnsA	unknown	unknown	gnl\|CDD\|378037
NC_019753.1\|WP_015201400.1\|326848_327748_+\|transposase	unknown	unknown	gnl\|CDD\|377670
NC_019753.1\|WP_015201409.1\|352874_357554_+\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237054
NC_019753.1\|WP_012411495.1\|318845_319091_+\|photosystem-I-iron-sulfur-center-protein-PsaC	unknown	unknown	gnl\|CDD\|177005
NC_019753.1\|WP_015201404.1\|332211_334308_-\|acylase	unknown	unknown	gnl\|CDD\|376618
NC_019753.1\|WP_015201396.1\|319346_321245_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_019753.1\|WP_015201399.1\|325235_326834_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379165
NC_019753.1\|WP_015201402.1\|329102_330521_+\|ISKra4-like-element-ISCep1-family-transposase	unknown	unknown	unknown
NC_019753.1\|WP_015201407.1\|336235_344794_+\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NC_019753.1\|WP_051035311.1\|323314_325246_+\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|378147
NC_019753.1\|WP_015201403.1\|330647_331280_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271197
NC_019753.1\|WP_157462386.1\|316482_317139_-\|DUF3120-domain-containing-protein	unknown	unknown	gnl\|CDD\|371465
NC_019753.1\|WP_041225822.1\|334363_335686_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_019753.1\|WP_015201397.1\|321771_322023_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_157462222.1\|323088_323247_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201408.1\|344842_352873_+\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NC_019753.1\|WP_157462387.1\|317611_318550_+\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712
NC_019753.1\|WP_015201406.1\|335992_336130_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201401.1\|328431_329106_+\|plasmid-pRiA4b-ORF-3-family-protein	unknown	unknown	gnl\|CDD\|377943

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_041225819.1\|328100_328412_-\|hypothetical-protein	gnl\|CDD\|379453	pfam14072, DndB, DNA-sulfur modification-associated. This is family of bacterial proteins likely to be necessary for binding to DNA and recognising the modification sites. Members are found in bacteria, archaea and on viral plasmids, and are typically between 354 and 474 amino acids in length. There is a conserved DGQHR sequence motif.	7.76692e-23
NC_019753.1\|WP_015201398.1\|322248_323055_+\|heteromeric-transposase-endonuclease-subunit-TnsA	gnl\|CDD\|378037	pfam08722, Tn7_Tnp_TnsA_N, TnsA endonuclease N terminal. The Tn7 transposase is composed of proteins TnsA and TnsB. DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The N terminal domain of TnsA is catalytic.	1.91949e-19
NC_019753.1\|WP_015201400.1\|326848_327748_+\|transposase	gnl\|CDD\|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	2.5625e-16
NC_019753.1\|WP_012411495.1\|318845_319091_+\|photosystem-I-iron-sulfur-center-protein-PsaC	gnl\|CDD\|177005	CHL00065, psaC, photosystem I subunit VII.	2.793e-53
NC_019753.1\|WP_015201404.1\|332211_334308_-\|acylase	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	2.03832e-148
NC_019753.1\|WP_015201396.1\|319346_321245_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_019753.1\|WP_041225822.1\|334363_335686_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.50276e-52
NC_019753.1\|WP_015201407.1\|336235_344794_+\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NC_019753.1\|WP_051035311.1\|323314_325246_+\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|378147	pfam09299, Mu-transpos_C, Mu transposase, C-terminal. Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology.	3.35044e-08
NC_019753.1\|WP_015201403.1\|330647_331280_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271197	cd01197, INT_FimBE_like, FimB and FimE and related proteins, integrase/recombinases. This CD includes proteins similar to E.coli FimE and FimB and Proteus mirabilis MrpI. FimB and FimE are the regulatory proteins during expression of type 1 fimbriae in Escherichia coli. The fimB and fimE proteins direct the phase switch into the 'on' and 'off' position. MrpI is the regulatory protein of proteus mirabilis fimbriae expression. This family belongs to the integrase/recombinase superfamily.	2.95836e-49
NC_019753.1\|WP_157462386.1\|316482_317139_-\|DUF3120-domain-containing-protein	gnl\|CDD\|371465	pfam11318, DUF3120, Protein of unknown function (DUF3120). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	3.78411e-102
NC_019753.1\|WP_015201409.1\|352874_357554_+\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237054	PRK12316, PRK12316, peptide synthase; Provisional.	0
NC_019753.1\|WP_015201399.1\|325235_326834_+\|AAA-family-ATPase	gnl\|CDD\|379165	pfam13401, AAA_22, AAA domain.	2.50537e-14
NC_019753.1\|WP_015201408.1\|344842_352873_+\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NC_019753.1\|WP_157462387.1\|317611_318550_+\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	8.87519e-94
NC_019753.1\|WP_015201401.1\|328431_329106_+\|plasmid-pRiA4b-ORF-3-family-protein	gnl\|CDD\|377943	pfam07929, PRiA4_ORF3, Plasmid pRiA4b ORF-3-like protein. Members of this family are similar to the protein product of ORF-3 found on plasmid pRiA4 in the bacterium Agrobacterium rhizogenes. This plasmid is responsible for tumorigenesis at wound sites of plants infected by this bacterium, but the ORF-3 product does not seem to be involved in the pathogenetic process. Other proteins found in this family are annotated as being putative TnpR resolvases, but no further evidence was found to back this. Moreover, another member of this family is described as a probable lexA repressor and in fact carries a LexA DNA binding domain (pfam01726), but no references were found to expand on this.	1.70051e-51

>NC_019753.1|WP_015201400.1|326848_327748_+|transposase
MLGFFPDPYPDELFYSICARFHHLVGYARWQTTVCELFGKVVKVTVAMPCRLKALVAALPPGHRYTVDRFIDEHTLFPFYSRFLSLTSANEIYSRMALSEKKTLFIRSGIPKYLQFCPTCVLQDRKQFGECYWHRLHQAPGVKICPVHRKFLQSSQISIQQHQCIAAEQALSKIEVEPSLNTHSIHPLFLQIAHDATWLLSQPHQTVDQQFIRNRYVQLMISAGFANSRGFFAMPQLINSFEQAYPVDCIKQLQCGFDLSAEPSWITITLQNWRQHQHPLRHLLLIHLLRCSAQDFFLT
>NC_019753.1|WP_015201399.1|325235_326834_+|AAA-family-ATPase
MNPELSAQPSLLVGKGRLEIATYKDPQIPNYQDNPLIEALPKILTSEEALTKLAHYPSYDPVQRTWPSHLRVHLIQSALQFFAPLPVHLDLEQRFSRLIRTGYQARNPQRPSFWGNLNQGVMSLSQEGSVSHLGRSTANGFTIIGMSGVGKTVSVESILSLYPQVIIHNHYRNRDFTHQQLVWLKLDCPFDGSIRGLCLNFFQAVDDLLGTQYYKNYQKGRPNVDALIPLMARVASLHCLGALVIDEIQHLSSAKSGGASLMLNFFVQLVNTIGVPVILVGTYKAWSVLSGEFRSSRRGTGQGDLIWDRMANDEIWQLFIESLWRYQYVQKLCPLTPTFSQVLYEVTQGITDLAVKVYVLAQLRAITTGKEVITKAIIQSVARDSLRLVNPVLNALKTGMTQQLQGFEDVHPIELGTFFQEAISTVQKVDYLNCLKASTTKSVDHNLLVATSLEQQGEITESTSLAAAIPETLPLKTSSPRRKITNKPQLITRETANNATTLIEIVTIGTAHQISGYEALKLAGLIQPTTEY
>NC_019753.1|WP_051035311.1|323314_325246_+|DDE-type-integrase/transposase/recombinase
MEIPVHYRQHRDKAWTIIGNCVSDERVFIPKEHGALILAMMAQKGCTKRTIYKYLRQYWQGGQNKNALLPRFDQCGGKAKERQCGEQKRGRPGKLAQITNQHQGVNIDVEMRERFRRGISLFYENATGRTLKDAYQLTLFKFFHQGYELHNQVWVPILPPAEELPTYRQFRYWYFKNQDLSKTLQSRLGQREFNLQHRALLGDSTQMAFGPGSLYQIDATIGDVYLVSSLNRHRIIGRPVIYLVIDVFSRLISGFSVSLEGPSWLGAMLALENATADKVAFCHEFGIEINSADWPSRHCPEAILADRGEFEGYNADNLVNALNIRVANTPPYRPDWKAIVERHFRTCNDKLIRFLPGAVHHKRSRGDRDYRLDAVLDLHQFRKLMILCILDHNQHHRLQGYQMDEFMINDAVEPYPVDLWHWGVRNRVGHLRTSSTDMMRLHLLPSAEATVTPKGIRCHKLLYTCDLALQQQWFVKARVQGSWKVKVAYDPRQLEQIYLRLNNNNQIVTCHLLPCSKTFSGRDWHEAIDYWAEKKLAMAAENSRSLQTTATFHAQVEQLVSEAVQHSELHQSSTSKQSRIQGIRETRRTEREQERSDLAWQLGVTEPQNNSSLSEKTNEEYVPPPQPLDLLRRLREESWNDEP
>NC_019753.1|WP_157462222.1|323088_323247_+|hypothetical-protein
MNLYVNQLLEWVGLTPPKIERLLWIEPAGNWVVTIEMCSTKALPIWQRMVDI
>NC_019753.1|WP_015201398.1|322248_323055_+|heteromeric-transposase-endonuclease-subunit-TnsA
MAKRKRSVTPEIIEERIKEGRGQGRGVNYKPWLTIQDVASTGTCSRIKGWKTQRIHHLLSELELSYFYVLEWSLIVNDIREQYPLLPLTETQSIAEECGFRYPTIPGTDNPIIMTTDFVISTNSSLEIVEQARTLKYAWDLQSKRKLEKLEIERRYWQRRGINWGIVTEREIPKSLVKNVAWLHPFGSRTDLKDMSKWEINRINKILTEKIRYSRQSLAEITAQSDDLLGFIPGTSLSVARYLLANRTWDFDINQPIQPQEPLVLLKP
>NC_019753.1|WP_015201397.1|321771_322023_-|hypothetical-protein
MELKDFLAKYPETTRNDLATICNCSLPTVTHWFVEGNSRRQLKEEHKLCLAIADYVWSRDLAEPEHFHVLRQIRRKQVARLHR
>NC_019753.1|WP_015201396.1|319346_321245_+|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGTQAATEIMLAGLEKLEYRGYDSAGIALVSEGELDRVRAKGKLRNLREKLEMQANPAQLGIGHTRWATHGKPEEHNAHPHTDTKKRIAVVQNGIIENYRELREELKKLGHEFLSETDTEVIPHLIAEFFSNPPAPAHAHIPSLLLEAVRQAVMKLKGAFAIAVISADFPDELIVVRQQAPLVIGFGQGEFFCASDTPAIVQYTRAVLPLENGELARLTPLGVEVYNFAGDRLKKTPRTLNWNPILVEKQGFRHFMVKEIYEQPGVVRTCLEAYLNHQWNPDSDQSPINLGIPTELYSDLEHIQIVACGTSWHAGLVGKYLLQELAQIHTNIEYASEFRYSPPPITANTLTIGITQSGETADTLAALAMVKERRENQPAKYQAKLLGITNRVDSSLASIVPDLIDTRAGIEIGVAATKSFIAQLMAFYFLALDLAYHRKTLSNVQIEEIITELRQLPAQIEIILESQERYIEELAHEFTETTDFIFVGRGINYPIALEGALKLKEISYIHAEGYPSGELKHGPIALLDAKVPVVAIAMPGKVYEKTLSNAQEAKARDSRLIGVIAMDDKEAAETFDELLPVPQVNELLSPVLTVIPLQLLSYHIAARRGLDVDQPRNLAKSVTVE
>NC_019753.1|WP_012411495.1|318845_319091_+|photosystem-I-iron-sulfur-center-protein-PsaC
MSHTVKIYDTCIGCTQCVRACPTDVLEMVPWDGCKAAQIASSPRTEDCVGCKRCETACPTDFLSIRVYLGAETTRSMGLAY
>NC_019753.1|WP_157462387.1|317611_318550_+|undecaprenyl-diphosphate-phosphatase
MGIGTASTLLTLATAEAGFTQQGLEPATTATTAQVNIFQALILGLVQGLTEFLPISSSAHLKVVPVVLGWGDPGVGFTAVIQLGSIAAVLWFFWGDLVQITTGSLRAIAQKDYQSDDFRIAAGIILGTIPIVFFGLLIKKFIPDFDNSPLRSLGAIAIASIFMSLLLGVAEKFGKRKRNFEQLGILDGVLMGLAQAMALIPGVSRSGSTLTAGLFMGLERATAARFSFLLGIPAITLAGLVELKDVFKAGLDGAGLVPIIVGVISAGFFSYVAIAWLLRFLQTQSTWVFIWYRLIFGVSILGAIAAGFLKNI
>NC_019753.1|WP_157462386.1|316482_317139_-|DUF3120-domain-containing-protein
MSEWETDISKYWWAFGAACFLVSVPVFVQAPLVRELPLLSLVLTAAWVWLGLLLIKRPATQLWGDLLLGFSWSWLAGSLYWGWLRWEPLIHLPVEAIGLPFVLWFLWRGWGKVGNFFYLGSLFGTAVTDLYFYIAGVIPHWRELMQVDPALATPILQNAIALVRTPWGVSWAGILVSLLLSVGIWSLGTKQIHWWAFSGAVLSTILVDSLFLVAASLA
>NC_019753.1|WP_041225819.1|328100_328412_-|hypothetical-protein
MYSISPKKNRSPVTLAALGHLGASLISNYPQTWEIHLKKLQQINWSRSNPEWQYRIIVGGRISKSRISVSLMTVYLKKTFGLALNINKNKLERDKLSKEKISL
>NC_019753.1|WP_015201401.1|328431_329106_+|plasmid-pRiA4b-ORF-3-family-protein
MSDSPEPVNYQLKVVLLGISPMIWRRILVLSDSTIEDLHYTLQISMGWEDIHLHHFIIHGKQYGVTQPGGTTFSTRACEVKLSTFGWQLKEKFLYEYDFSICPSMGTWRYWWRHQIRLEAISAAQAKQTYPVCTGGKGVCPPEDCGGAWGFMETRQEYSGWHILERFGSMLEEEDWTEYREELCQLQTWLLVDQNHFDRAQVNSRLQQYASRDKELMLYEQGIG
>NC_019753.1|WP_015201402.1|329102_330521_+|ISKra4-like-element-ISCep1-family-transposase
MKLKIQVVIESDNGDREIIQEITQIERGILQPENLGLSLVEAKTLLNKVQRTLVQQQVTEYEKQHDSCQHCENKLLRKDKRIVVYRTLFGKLKLQCNRLFQCTCQEQSTRTFKPLGKLLKERISPELLYLESKFVSLMSYGLSVKLLEELLPIEGEISVTTVRNKLHVCAQRLESELGEEKRVYIEGTQRDWDNLPRPELPLVVGVDGGYVRFYDKKSSTKGNFEIIVGKSIKSDNTSKRFGGVYSYDTKPQRRIFEVLKSQGMQMNQQVTFLSDGDEKLRDLMFGLNPNTEYLLDWFHITMRLTVINQMAKGINKKDTELNTDIPKDLERIKWYLWHGNVFRALQLLKDFVDDLEVEVFNGNAQREVKKLLKMVQEFETYIFNNGACIPNYGERWHNDEAIATGFVESTVNQVISKRFVKKQQMRWTPKGAHLLLQMRMLVLNGELRRQFEQWYSGLRLDNEPNLQIPNSV
>NC_019753.1|WP_015201403.1|330647_331280_+|tyrosine-type-recombinase/integrase
MTAQTLQLPKVGKTEKQERQSPNSHKYFEVRTREYLLPEEVSAIRLAIKKSKGRHAHRDSTLILLCYRHGLRVAEVASLRWEQIDWSGGTIYVKRVKKGTPWVQPLSGLEIRSLRQLLRNYPASPYIFQSSRLGPLAHDTISGIVERAGELAGLPFPIHAHMLRHGTGYYLANRGIDTRTIQSYLGHKNIQHTVHYTELASTKFQGLWDD
>NC_019753.1|WP_015201404.1|332211_334308_-|acylase
MLFTLSKRLAFRLFSFILGITFFIAIAGYHPVFAQKSTEILWDTYGVPHIYGKDTKGLFRAFGWAQMQSHGDLILRLYGQGRGRAAEYWGKEYLDSDRWVRTMKVPERAQEWYQAQNKNFRLNLDAFAEGINAYAKEHPELINDAVEAVLPVTGVDILAHGQRVLNFTFVVDPDTVAGITNADKSKGSNGWAIAPTHSASGKAMLLANPHLPWSDLYLWYEAQLTAPGIDAYGATLVGLPVLEIAFNDFLGWTHTVNTFDGWDAYELKLKNNGYLWDGKVKAFETEQQEIKIKQDDGTIKSELLEIKRSIHGAVVSQKDDKAIAIRVVGLDRSGGLEEWWDMSRAHNLTEFESALKRLQIPMFTVMYADREGHIMHLFNGQVPVRSKGDFKYWQGVVPGDTSATLWTKIHPYRDLPRILDPVSGWLQNTNDAPWTTTFPVAINPDNYPPYIAPRGQMSLRSQRSARMLMEDEKISFPELIEYKHSTRVELADRVLDDLITAARQSGNNLTKQAADVLAKWDRNTNADSRGAVLFATWRQLVDRKRLFAVPWSENAPLTTPKGIGDRANAVTALETAANNVRSTYGSLDVPWGQVFQLKNGKTNLPANGSNDALGVFRNVWYASEKKGKRQAIGGDSFVAAIEFSNPVKAMVLTTYGNSTQPNSTHINDQLELFEEKKLRSVWRKRAEIEAHLESQKVF
>NC_019753.1|WP_041225822.1|334363_335686_-|MFS-transporter
MRQETFPTNMRTFSILWCGQMISTIGSYMTAFTLTIWVWELTGQATALALVGFFTQVPRVLISPLAGVIVDRYNRKLLMMVGDGVAAFSSLAMLLLFLTGHLQVWHLYLAGLLEGTFGQIQELAATASITMVVPKQHYTRAMGMISTLHYGSNIIAPALASVLYSIIGLSGILSIDLITFAVAVSTLLFVDIPQPHTADSQNQPQSQKFSWKEIIFGFQYIFDRPSLLALMIAAAMFQFAHDLGAALYAPMILARSGNNTQLLGSVAAAAGIGGVIGAILVSTWGVPKQKIHGLLLGMIGAGLSKIVFGLNRIPLILIVAQFCSSLNFPLMGSCRDAIWLSKINHNLQGRVFAARSTIMLITSAIAPLIAGFLADQVLEPAMMPGESLANIFGSILGTGRGAGIALLYVLTSVCLLLIGLGGYTFKNLREVENNLLETGQ
>NC_019753.1|WP_015201406.1|335992_336130_+|hypothetical-protein
MKLGIAVVAIEPAATNYPSSLTVQVLLQLSVGMAVSGIMLRKLEF
>NC_019753.1|WP_015201407.1|336235_344794_+|non-ribosomal-peptide-synthetase
MSDPKLSLSFCTLVDLLRYRSIHQSEDIAFAFLQDGETEETSLTYQELDRRSRAIASYLQALNLSGERALLLYPAGLDFLAAFFGCVYSNVIAVPLYPPKLKRNLGKIQAIATDAQATVVLTTSQHLVNLDQLFAKAPDLKALRWIATDTIADVSDLWQPPVLQGDSLAYLQYTSGSTSTPKGVMISHENVLYNIAYIDKGFEHTADSVAVTWLPHFHDMGLIDGLLKPLYKGIPCYFMPPAAFTQRPIRWLQAISRYKATHSGAPNFAYDFCVRKITPEQRANLDLSSWSVAYNGAEPIDHEVLEKFVEAFASCGFRAEAFCPAYGMAETTLKVCTVSKNDAPIVCTVDKAALEKNQVVEIFSPQVETWGYTNKARLRGLMGNNIRSLVGCGKPDFGTKVVIVNPDSFKQCGENEVGEIWVSGTTVAQGYWNRQEETESTFKATLADTGEGNFLRTGDLGFFHNGELFITGRLKDVIIIRGRNLYPQDIEKTVERSHSALRLSAGAAFAVEVGREEQLVVVQELELRQSGNLEEVIAGIRSAIAAEYEVQPYAVVLIKYGSIPKTTSGKIQRRACKAQFLAGELEIVASSVLENTDYLAAEVSLNREILLATDLNERQTSLEDYLRSQIAKILKVSYVNVDLQQPLSNLGLDSLKLFELKNQIEIDLSVVLSVIELFEDISIAQLATLILGEITTSAPVVSGIKPVNREQELPLSFAQERLWFFDQLEPGNPFYNLAATIDIKGQLNIDALTYSLNEIVKRHEVLRTKFVNHNGKPVQVILNDISWDLSIIDLTSFSAEQRKIEVENLCLKAAQSPFNLQQCGLFRTQILRISETEHILLIAVHHIVFDGWSIRLLLQELAAFYQISTNNLRSLPNLPIQYADFAVWQRQWLQDEVLPNQLKYWQQKLSGNLPVLNLPTDFTRPVVQTFQGNKHIFIIPKNLTANLRKFSKEKKVTLFMLLMAAFKTLLYRYTGQEDILVGSPIANRNHSEIEKLIGFFANTVVFRTNLSSNLTFTNLLLRVRETALAAYQHQDVPFEKLVEVLQPERDLSRNPIFQVLFALHSFSKPELAVAEVNFSLQEIDTRTARFDLALDLWEESEIIRGSLEYNQDLFENATIVRIASHFQTLLESIISDPEQRISTLNLLTEFELKQIGIDYSSTKITSQPLQCIHEIFELQADKSPDAIALRAHSVNAVCEQQKLNYQELNQRANQLAHYLQKLGVKPEVRVGIYVERSLEMIVGMLGILKAGGAYVPLDPSYSNERLQFMLEDAQVNVLLTQAHLHDKINSDQILKVCLDRDWKVISQERHTNCVSEVTPKNLAYVIYTSGSTGKPKGVEITHASVVHLFAATCPTFNFNERDVWTVFHSYAFDFSVWEIWGALLHGSRLVIVPRNLTQSPEEFYNLLVKEQVTILNQTPSALRQLVAAHSELVTGDLNLRLIVCGGEAFPQELAEKILAWNVPVWNFYGPTEATVWATIQQIKGIYSINKVIPIGKAIADKQIYILDSNLQPLPIGIPGEIHIGGIGLARGYLNQVELTAEKFINNPFKPSGKLYKTGDLGRYLPDGTIEFIGRIDYQVKIRGFRIELGEVETVLSQHPAVKQVVVVDQNDELGNKRLVAYIVTKSEQIPNSELRQFLTEKLPEYMVPSAFVILEALPVTANGKIDRKALPAPNFSERELASSFVAPRTPIENLLAEIWRKVLGVTQIGIHDNFFALGGHSLLATQLIAKVREEFQVELPLRSLFQFPTIATLAEQISQPSITTEKAVNLLPTITPDINHKYQPFPLTDIQQAYWVGRSSAFELGNVATHIYVEIDAVELDLERFNLAWQRLIERHDLLRVIILPDGQQQILKEVPTYQVKVLDLQGQSAEGINLQLEKVRDRLDHQILPSDKFPLFEICASQLDQRRTRLHFSFDLLIADAWSFQIIGRELAALYQNPEVELTPLQISFRDYVLAEVNQRNSEQYRRSQEYWRDRIATLAPAPELPLAQNPSAIKHPRFVRHSGKLQADKWQQLKNYASIAGITPSAVLLAAFAEVLTVWSKNPRFTLTLTLFNRLPLHSQVNELVGDFTSISLLEVDNSAEDTFGDRARRLQAQLWEDLDHRDVSGVQILRELARTQGRLSSALMPVVFTSTLTQEALGEQKFPLDWLGEMTYGITQTPQVFLDHQVAEEAGALVFNWDAVEAIFPTGMLDDMFAAYCNFLESLAQREENWQEIHPRLIPQTQLNQFAAINATDAAISSDLLHTLFTAQVDLQAEKVAVVTSDRTLTYAELYRLANQLGHKLRDLGAKPNQLVAVVMEKGWEQVVAVLGILMSGAAYVPIDPKLPQERRSHLFKQAEIQLVVTQPCVDKRLYWSEGIQRICVDIPDAETRSIASTLEPVQKPEDIAYVIYTSGSTGLPKGVTIDHRGAVNTILDINHRFNVQASDKVFALSALNFDLSVYDIFGTLAAGSAIVIPDASATQEPSHWAELMQREQITIWNSVPALMQMMVDYGCNNSAIFQHLRLVMLSGDWLPLNLPNQIKALNSETEVISLGGATEASIWSIYYPIESVNPYWKSIPYGKPLQNQHFYVLNHALEPCPILVPGQLYIGGIGLAKCYWRDEAKTSASFITHPRTGERLYKTGDLGRYLPDGNIEFLGREDFQVKIGGYRIELGEIESALLKHPAVREAVVNAVGEKPTHKRLVAYIIPTEETPQIEELRSFLSEKLPAYMIPSAFVMLESLPLTANGKVNRQALPIPSAIQEIDSTVVAPRNSTETTLAKLWFEVLGVENISIYDNFFDLGGDSILVTQLITKVREVFQVELPLRDFFEQPTIAAFVECLEKAKNSGSKPEESEIVPISRKAYRMKLSSL
>NC_019753.1|WP_015201408.1|344842_352873_+|non-ribosomal-peptide-synthetase
MISSLETPTDINNLIDAEEVFVLPVSFSQQRLWFLDQLESGNAFYNQSNAVKLTGKVDVVALEKSFNALVERHEILRTTFVKVDDQPMQVIRPNLTLPMSVIDLRGVVEIDSEVERLAVEHARYIFDLTKAPLLKTTLLQVGDEEYVLLITMQHIISDGWSKGIFIKEIAAFYKAFSTGKPAFLPELSIQYADYALWQRDRIKGELLEKHLNYWKNQLQDATPLLELPTDRPRPPIQTYQGAVETLALPKTLTDALKNLSRQKNVTLFMTLIAAFKTLLYRYTGQYDILVGSPIANRQRAELEQLIGLFVNTLVLRTDLSENPSFDELLRRVQQVALDAYAHQDLPFEKLVEELQPERNLSYAPLFQVMFVLHNAPMPPLQLPGLKLEILDIDSKVAQFDLTLHLFDKPEGLTGWFEYSTDLFDRATIQRLIGHFETLLAGIVNNSEQKVSELPILTAAEQQQLLFEWNNTQTDYPLNQCLHELIEAQVEKTPDDIAVVFQNQELTYQELNHRANQLAHYLQKVGVKPETLVGVCMERSLELVIALLGILKAGGAYVPLDPSYPSERLAFMLEDAEFSVILSQQKLVETFPETSLHEDKPQIFCLDTGWQILAQESINNPISNIKPDNLAYVIYTSGSTGKPKGAMNTHKGICNRLLWMQDTYQLTTADRVLQKTPFSFDVSVWEFFLPLLTGARLVVSKPEGHKDRDYLVDAIAQYQITTLHFVPSMLQKFLEAESLDKCQSLQQVMCSGEALPYELQQHFFTKLPKVKLHNLYGPTEAAIDVTFWECQSNSELKIVPIGRPIANTQLYILDSYLQPVPIGIPGELHIGGVGVARGYLNRPELTKEKFIPNLFLTSTLQGEGVGGLGSNLYKTGDLVRYLPDGNIEYLGRIDNQVKIRGFRIELGEIETVLTEHPAVKQSIVITREDRTGTKQLVAYIVFLNRRCEQINADDADVKEDFADLCKKFNVDEFLVNFELDLRRYLKEKLPEYMIPTAFVVLESLPLTHNGKIDRKALPAPNYNREELASNFVAPQTQEEKLLAEIWAQVLGLEKVGVRDNFFALGGDSIRSIQVQSLAQKQGFSFSLHQLFQYQTIYELVQQLQPTTADTTTNLVAAFSLISESDRKKIPENIEDAYPLARLQAGMLFHSQYSEESATYHDIFSFYLKAPFDAEILQEAIENIVNRHPVLRTSFDLKSFSEPLQLVHQTANLALQVEDLQHLSASEQSEKINAWLEAEKQQHFDLSQPGLLRFQIHLRSAKTFQISVSFHHVILDGWSVAAMLTELFQDYLSVEAGYIASLQPELLSKFRDFVVLEREAIASPSYQDYWQTKLSDRNIAKLPRWHSSQRSEIREIRSQQVVISSEICEGIKQLTKSAAVPLKSVLLTAHLRVLSILSGQSDIISGLVVNGRPEQTDGEKVLGMFLNTLPFRLQLTGGTWTELVQQVFAAESELLPYRCYPLAELQKYSGGQPLFEAAFNFVNFHVYQGLQDFPEIEVLDARVFEATDIPLFTDFSVDPFSQQVKIILQYDAQEFCVEQIDAIALYYLRCLEAMAKEPQERYEVRSLLSEQEQHQLLIEWNNTKKDYPQDQCIHQLFEAQVERTPDAVAVVFEGQQLTYRQLNEKANQLAHYLQKLGVKPEVSVGICVERSLEMLVGILGIVKAGGAYLPLDPAYPDQRLAFMLADAQVSILLTQQSVETLYATSLQEKRVVYLDTDWQLISQESQKNPETTVKPENLVYVIYTSGSTGQSKGVAVQHSNLVNAYFAWEEAYQLHQVTSHLQMASFSFDVFSGDMVRALCSGGKLVLCPRDLLLTPHQLYELMQREKIDCAEFVPVVLRNLIQYLEDTSNSLEFMRLLICGSDSWYGSEYQKFRQFCGSQTRLINSFGVTEATIDSAYFESADTNSLPLLRGGLGRGSTQQLVPIGKPFANTQLYILDNYLQPVPVGVYGELYIGGAGVTRGYLNRPELTADKFINNPFNLAEKLYKTGDIARYLPDGNIEFIGRSDDQVKIRGFRIELAEIEAVLSQHPEVQQAVITVREAQPNQKSLVGYFVSNVETLSATPLPNTKSIDLRSFLQERLPEYMVPAAFVELVELPLTPNGKVDRKSLPAPDSTNSNLATDFTSARNTVEEQLANIWADVLRLTQVGIYDNFFELGGDSILSIQIIAKANQAGLNLTPKLLFQYPTIAELAAAAGTNQIIHTEQTPVTGNVPLTPIQNWFFEENFVDAHHWNQAVLLEVKQPLKSAILEKATQQLLIHHDALRLRFVKGESGWQQFNAEPNHIIPLIVKDLSALSSTEQLLEMEAVADELQASLDLTAGKIVRFGLFNLGITSRLLIVIHHLAVDGVSWRILIEDLQTAYAQLEQGKTVQLPRKTTSFKYWSERLSKYARSLSIQPELNYWLEQAKQPVSRMPLDWVDGVNTVATSHTLSVSLSVEETQLLLQEVPKLYRTQINDVLLTALLQVFNHWTGQTSLLIDLEGHGREELFDDIDISRTIGWFTSVFPVRLHTEQLTNSVETLKSVKEQLRSIPNRGIGYGLLRYLNSDRLQLAKLPQAEISFNYLGQFDQTFTESTLFDLAKESAGASQSKREHRTYLLEINGLVTGGQVQFDWTYSEAVHHRSTIESLAQSFIEALKSLINQSQLKDAIAYTPSDFSEFEWSQWNQSDIDDILTAIGEV
>NC_019753.1|WP_015201409.1|352874_357554_+|non-ribosomal-peptide-synthetase
MSKKNIEDFYPLSPMQQGMLFHSIYAPNSGVYFEQLSCTLNGNLNLELFKQTWQQVIDRHPILRTAFIWEGVKEAVQVVHRQIQLPWQQFDWKDLSATEQQQELENFLQAEEESGFQLNKAPLTRLTLIQVAKDSYYFIWSHHHLLLDGWSTPLLLQEVFTTYSALCKGEQISLPRPRPYRDYIVWLQQQKLGEAECFWREKLKNFTAPTPLSVEMSVGSGGEKYDAQQIQLSATATSALQALTRQNQLTLNTLVQGAWALLLSRYSGEKDIVFGTTVSGRPPTLLGADAMMGLFINTLPVRVGVQGEDALIPWLQQLQAQQTEARQYEYTPLLEIQGWSEVPRGVPLFESLLVFENYPLESSLQQPIANLEIQNVRMFEKTNYPLTVIAVPDSELLLKIAYDTRRFDAATITRMLGHIQTLLEGIAVNPHQCLDKLPLLTDAERHQLLIEWNATETDYPKICIHQLFEAQVEKTPNAVAAVFEDQQLTYQELNIRANQVANYLQSLGVQPDSLVAICVERSLEMLVALLGILKSGAAYLPLDPAYPQERLAFMLEDAQVSVLLTQQDIVETLDAKSLRKSHIKLVCIDRDWEMIFQSSQQQPMSQVNSNNLAYVIYTSGSTGKPKGVQICHASAVNFLCSMHQQLEINETDVLLAVTSLSFDIAGLELFLPVTSGSCVVIASREVAIDGNKLIAKIHESSATIMQATPATWRMLLTAGWQGNQKLKILCGGEALPQQLANELLNKSACLWNLYGPTETTIWSTIYQVKEPNNLVFIGRPIANTQIYLLDRNLQPVPVGVAGELYIGGAGLSRGYLNRPELTTERFIANPFIEGNSIYQTGDLARYLPDGNIEYFGRIDDQVKVRGFRIELGEIEAIISQYPLVQQAVIVAKEDNSGDKYLAAYIIPHVASPENTISSELRNWLQDKLPSYMIPSSFVVLEKLPLTPNGKIDRKALPAPDNAISELGRGLVTPRTQTEEIVSSIWAQILGLKQVGIYDNFFELGGHSLIATKVISRLREAFQIEIPLSWLFESPTVAALTQRIQTEIKGKKQLEIPPLAVVPRTENSPLSFSQQRLWFLQQLTSNSPEYNISSAVKLTGSLNIAALERSLSEIIRRHEALRTRFVDVDGQPVQVIEKMPTGYQACVGRLSSYSPTLQGVGLPVIDLSDIPASEREDKARWLAKQDAEQFFDLTKCPLLRFSLVRLDAQSHIFILTMHHIISDAWSLGVFLEELATLYKVFASKDVADNFSTILPELPIQYADFAIWQRQWLQGDVLQTQLDYWKQQLGQNCLPLEFPNSRSRSTVPSNQGAKLSFVLPKDLTEAIAQLSRQSGVTLFMTLLAAYQTLLYCYTGQEDIRIGSPIVNRNQVELEKLIGFLINTLVLRGDLSGNPSFKELLVRSRQVTLGAYAHQDLPFDKLVEALQPERKIGQTSLYHAWFVLQNTPTPPLELAGLTMSLLDIETTTARHDLLLNVFEITEGLHCTFEYKTDLFNQATIARIAQSFQTLLHHVVAQPNSKLSELATIIAETDKQQQLSQEQEMQTANIQKLKSIKRKAIHS

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Crispr_ID: NC_019753_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_2

653799-656145

TypeIII

Consensus_repeat	Method
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	PILER-CR
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CRISPRCasFinder
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CRT

31 spacers

csx3,cas10,csm3gr7,csx19,csm6,cas6

The CRISPR arrays of NC_019753_2

>merge|NC_019753|2|653799-656145|PILER-CR,CRISPRCasFinder,CRT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACATTTTTTATCCAGATTTTTCCCCAAATTTGCAATAATTGCTACTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACTTCTGTAGAGTTATTGTATAAGAACCCCACGTAGAAACGAGCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACAGTCTCTTCTCCGGGAGGTTGAGTTCCTGGAGCTGTCTGCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACCATTAATAGTATATTACCTTTGCACGTTTTGCATTTCCAGAATCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACCTTGTAATCGCAAACTTTAATCCTTTCATTTTTTTTCTCCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACTTCATTGGTTTTGCCAGGATGATTTTTAGCAGCGCCAAAATCGAAACTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACCTGGAGCTGGTTGTTGAACATTCTCACTATCTTCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACGCCATTACATGGACCTGATCCAACTTGTAATTGTGAGTCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACAAAAAATTCGAGTCGATGGGAGCATACAGTTTACCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACATTCATGGCTTTCTGTAACTGAATCACTAATACAGCGACACTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACTTAAATCTCCGATCTTTTGACGTGTGCCAATTACAAAATTGCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACGAAAAGTTGTACCATGCACTATGGTACAACGAAATTGGACTAGAGACTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACTTTCCCAATAGTCCGACAACTTTAATGAGTCAGCAGGATATTCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACAAATTATCTATGCAACAGACCTCTTTACGAAGTTTTTTTTTCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACTTCTTAATATATAGATTCTTTCACCGCCAGTTATTACCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACTATCTTTCTCCCAACTTCCGTGATCATGATTAGCAACTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACCAAAGCATCCCACATAACTTCTTTCAACTGTTCCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACCTTGTTCAGCATTTCTTGATACGTATTTACCAGTCCCCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACAATACTCGAACAAATTTACAAGGAATAGTGAACGGTACTACTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACCTCAACTTTCTTACAGGTTACCGTTAAATCAGCTGACCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACGCTACTCCCTCTTCATAGGACTTAACATCCTTTTCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACAAATCCTTGCGCTGACTTTGACATTTGAACTTCTCCCCCACCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACAGATTTTGTTGTACCACCTTTATCAACCCAGTTTACCCACTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACGCTTTGGAAGGATGTTCACTCATTAGTACTACTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACATTCTTCTGATTCCTTATTTAAATCTTCAGCTTTATTTTCTCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACCTTAGGAAAGGATCTTCTTGTTCATAGATATTTAACAACTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACTGCTGTAGTGACAGTCCATTGGTTTAAACTCAGATGATTCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACGTAGGATCTGCAACAGCATTAGCGGGAGGATGTCAATCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACTTTTTTCCTTATTTGCTTCTAAAAATAAGTAACCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACGTGCTATGAGTGCTAGGTACAGTGACAAAATGTTTGTCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACCAGCAACTCCCTCTTCGTAGGACTTAACGTCCTTTTGAACTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACA

>NC_019753|2|2|653799-656144|PILER-CR
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	ATTTTTTATCCAGATTTTTCCCCAAATTTGCAATAATTGCTA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTCTGTAGAGTTATTGTATAAGAACCCCACGTAGAAACGAG
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AGTCTCTTCTCCGGGAGGTTGAGTTCCTGGAGCTGTCTG
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CATTAATAGTATATTACCTTTGCACGTTTTGCATTTCCAGAAT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTTGTAATCGCAAACTTTAATCCTTTCATTTTTTTTCTC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTCATTGGTTTTGCCAGGATGATTTTTAGCAGCGCCAAAATCGAAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTGGAGCTGGTTGTTGAACATTCTCACTATCTT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GCCATTACATGGACCTGATCCAACTTGTAATTGTGAGT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AAAAAATTCGAGTCGATGGGAGCATACAGTTTAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	ATTCATGGCTTTCTGTAACTGAATCACTAATACAGCGACA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTAAATCTCCGATCTTTTGACGTGTGCCAATTACAAAATTG
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GAAAAGTTGTACCATGCACTATGGTACAACGAAATTGGACTAGAGA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTTCCCAATAGTCCGACAACTTTAATGAGTCAGCAGGATATT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AAATTATCTATGCAACAGACCTCTTTACGAAGTTTTTTTTT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTCTTAATATATAGATTCTTTCACCGCCAGTTATTAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TATCTTTCTCCCAACTTCCGTGATCATGATTAGCAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CAAAGCATCCCACATAACTTCTTTCAACTGTTC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTTGTTCAGCATTTCTTGATACGTATTTACCAGTCCC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AATACTCGAACAAATTTACAAGGAATAGTGAACGGTACTA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTCAACTTTCTTACAGGTTACCGTTAAATCAGCTGAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GCTACTCCCTCTTCATAGGACTTAACATCCTTTT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AAATCCTTGCGCTGACTTTGACATTTGAACTTCTCCCCCAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AGATTTTGTTGTACCACCTTTATCAACCCAGTTTACCCA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GCTTTGGAAGGATGTTCACTCATTAGTACTA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	ATTCTTCTGATTCCTTATTTAAATCTTCAGCTTTATTTTCT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTTAGGAAAGGATCTTCTTGTTCATAGATATTTAACAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TGCTGTAGTGACAGTCCATTGGTTTAAACTCAGATGATT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GTAGGATCTGCAACAGCATTAGCGGGAGGATGTCAAT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTTTTTCCTTATTTGCTTCTAAAAATAAGTAAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GTGCTATGAGTGCTAGGTACAGTGACAAAATGTTTGT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CAGCAACTCCCTCTTCGTAGGACTTAACGTCCTTTTGAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC

>NC_019753|2|1|653799-656145|CRISPRCasFinder
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	ATTTTTTATCCAGATTTTTCCCCAAATTTGCAATAATTGCTA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTCTGTAGAGTTATTGTATAAGAACCCCACGTAGAAACGAG
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AGTCTCTTCTCCGGGAGGTTGAGTTCCTGGAGCTGTCTG
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CATTAATAGTATATTACCTTTGCACGTTTTGCATTTCCAGAAT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTTGTAATCGCAAACTTTAATCCTTTCATTTTTTTTCTC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTCATTGGTTTTGCCAGGATGATTTTTAGCAGCGCCAAAATCGAAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTGGAGCTGGTTGTTGAACATTCTCACTATCTT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GCCATTACATGGACCTGATCCAACTTGTAATTGTGAGT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AAAAAATTCGAGTCGATGGGAGCATACAGTTTAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	ATTCATGGCTTTCTGTAACTGAATCACTAATACAGCGACA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTAAATCTCCGATCTTTTGACGTGTGCCAATTACAAAATTG
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GAAAAGTTGTACCATGCACTATGGTACAACGAAATTGGACTAGAGA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTTCCCAATAGTCCGACAACTTTAATGAGTCAGCAGGATATT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AAATTATCTATGCAACAGACCTCTTTACGAAGTTTTTTTTT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTCTTAATATATAGATTCTTTCACCGCCAGTTATTAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TATCTTTCTCCCAACTTCCGTGATCATGATTAGCAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CAAAGCATCCCACATAACTTCTTTCAACTGTTC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTTGTTCAGCATTTCTTGATACGTATTTACCAGTCCC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AATACTCGAACAAATTTACAAGGAATAGTGAACGGTACTA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTCAACTTTCTTACAGGTTACCGTTAAATCAGCTGAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GCTACTCCCTCTTCATAGGACTTAACATCCTTTT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AAATCCTTGCGCTGACTTTGACATTTGAACTTCTCCCCCAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AGATTTTGTTGTACCACCTTTATCAACCCAGTTTACCCA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GCTTTGGAAGGATGTTCACTCATTAGTACTA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	ATTCTTCTGATTCCTTATTTAAATCTTCAGCTTTATTTTCT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTTAGGAAAGGATCTTCTTGTTCATAGATATTTAACAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TGCTGTAGTGACAGTCCATTGGTTTAAACTCAGATGATT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GTAGGATCTGCAACAGCATTAGCGGGAGGATGTCAAT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTTTTTCCTTATTTGCTTCTAAAAATAAGTAAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GTGCTATGAGTGCTAGGTACAGTGACAAAATGTTTGT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CAGCAACTCCCTCTTCGTAGGACTTAACGTCCTTTTGAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACA

>NC_019753|2|1|653799-656144|CRT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	ATTTTTTATCCAGATTTTTCCCCAAATTTGCAATAATTGCTA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTCTGTAGAGTTATTGTATAAGAACCCCACGTAGAAACGAG
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AGTCTCTTCTCCGGGAGGTTGAGTTCCTGGAGCTGTCTG
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CATTAATAGTATATTACCTTTGCACGTTTTGCATTTCCAGAAT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTTGTAATCGCAAACTTTAATCCTTTCATTTTTTTTCTC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTCATTGGTTTTGCCAGGATGATTTTTAGCAGCGCCAAAATCGAAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTGGAGCTGGTTGTTGAACATTCTCACTATCTT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GCCATTACATGGACCTGATCCAACTTGTAATTGTGAGT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AAAAAATTCGAGTCGATGGGAGCATACAGTTTAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	ATTCATGGCTTTCTGTAACTGAATCACTAATACAGCGACA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTAAATCTCCGATCTTTTGACGTGTGCCAATTACAAAATTG
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GAAAAGTTGTACCATGCACTATGGTACAACGAAATTGGACTAGAGA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTTCCCAATAGTCCGACAACTTTAATGAGTCAGCAGGATATT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AAATTATCTATGCAACAGACCTCTTTACGAAGTTTTTTTTT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTCTTAATATATAGATTCTTTCACCGCCAGTTATTAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TATCTTTCTCCCAACTTCCGTGATCATGATTAGCAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CAAAGCATCCCACATAACTTCTTTCAACTGTTC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTTGTTCAGCATTTCTTGATACGTATTTACCAGTCCC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AATACTCGAACAAATTTACAAGGAATAGTGAACGGTACTA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTCAACTTTCTTACAGGTTACCGTTAAATCAGCTGAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GCTACTCCCTCTTCATAGGACTTAACATCCTTTT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AAATCCTTGCGCTGACTTTGACATTTGAACTTCTCCCCCAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	AGATTTTGTTGTACCACCTTTATCAACCCAGTTTACCCA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GCTTTGGAAGGATGTTCACTCATTAGTACTA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	ATTCTTCTGATTCCTTATTTAAATCTTCAGCTTTATTTTCT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTTAGGAAAGGATCTTCTTGTTCATAGATATTTAACAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TGCTGTAGTGACAGTCCATTGGTTTAAACTCAGATGATT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GTAGGATCTGCAACAGCATTAGCGGGAGGATGTCAAT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	TTTTTTCCTTATTTGCTTCTAAAAATAAGTAAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GTGCTATGAGTGCTAGGTACAGTGACAAAATGTTTGT
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CAGCAACTCCCTCTTCGTAGGACTTAACGTCCTTTTGAA
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_157462253.1\|659668_659836_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201655.1\|647875_648799_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_041225881.1\|652413_652923_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201652.1\|646406_647015_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201659.1\|660857_662537_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|224272
NC_019753.1\|WP_015201665.1\|673232_674420_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NC_019753.1\|WP_041226273.1\|662600_664913_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|377130
NC_019753.1\|WP_015201648.1\|642625_643393_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201650.1\|643680_644655_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201653.1\|647108_647495_+\|four-helix-bundle-protein	unknown	unknown	gnl\|CDD\|377534
NC_019753.1\|WP_015201651.1\|644771_646244_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223021
NC_019753.1\|WP_015201663.1\|667026_669369_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NC_019753.1\|WP_041225888.1\|675374_675920_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_051035335.1\|659834_660161_+\|hypothetical-protein	csx3	mkCas0115_csx3_CAS-I:CAS-III	unknown
NC_019753.1\|WP_015201662.1\|666442_667027_+\|TIGR03984-family-CRISPR-associated-protein	csx19	cls001376_csx19_CAS-III-D	gnl\|CDD\|274900
NC_019753.1\|WP_083890050.1\|649781_650471_+\|D-alanyl-D-alanine-dipeptidase	unknown	unknown	gnl\|CDD\|350617
NC_019753.1\|WP_015201661.1\|664920_666450_+\|hypothetical-protein	csm3gr7	cd09683_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187857
NC_019753.1\|WP_015201649.1\|643446_643647_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201664.1\|672071_673214_-\|CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NC_019753.1\|WP_015201654.1\|647555_647906_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015201663.1\|667026_669369_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	1.31148e-103
NC_019753.1\|WP_015201664.1\|672071_673214_-\|CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	1.26278e-44
NC_019753.1\|WP_015201659.1\|660857_662537_+\|hypothetical-protein	gnl\|CDD\|224272	COG1353, COG1353, Predicted CRISPR-associated polymerase [Defense mechanisms].	0.00100674
NC_019753.1\|WP_015201662.1\|666442_667027_+\|TIGR03984-family-CRISPR-associated-protein	gnl\|CDD\|274900	TIGR03984, hypothetical_protein_FrEUN1fDRAFT_5778, CRISPR-associated protein, TIGR03984 family. Members of this protein family are found exclusively in CRISPR-containing organisms, in operon contexts with RAMP (repeat-associated mystery protein) proteins also linked to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats).	1.82726e-32
NC_019753.1\|WP_083890050.1\|649781_650471_+\|D-alanyl-D-alanine-dipeptidase	gnl\|CDD\|350617	cd14840, D-Ala-D-Ala_dipeptidase_Aad, D-Ala-D-Ala dipeptidase (includes Lactobacillus plantarum Aad peptidase). D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. This subfamily includes Lactobacillus Aad peptidase and belongs in the MEROPS peptidase family M15, subfamily D.	5.93405e-99
NC_019753.1\|WP_041226273.1\|662600_664913_+\|hypothetical-protein	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	5.21522e-18
NC_019753.1\|WP_015201661.1\|664920_666450_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	4.08546e-18
NC_019753.1\|WP_015201665.1\|673232_674420_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	9.13429e-34
NC_019753.1\|WP_015201653.1\|647108_647495_+\|four-helix-bundle-protein	gnl\|CDD\|377534	pfam05635, 23S_rRNA_IVP, 23S rRNA-intervening sequence protein. This family consists of bacterial proteins encoded within an intervening sequence present within some 23S rRNA genes. It folds into an anti-parallel four-helix bundle and forms homopentamers.	7.47783e-36
NC_019753.1\|WP_015201651.1\|644771_646244_+\|ATP-binding-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	3.52127e-05

>NC_019753.1|WP_041225881.1|652413_652923_+|hypothetical-protein
MTSQLTFWLPGKCSPKVRPRATVINQSHSVSIKKSKAHVYNCPRYTAWKNWAISSLYRQFLNQNKSYKQEPLEHIEILIVFIGKHRGDGENMVGAVLDSAVQANIITDDCLKNIPKGCWEHKEATDPKITGTLILIKPIEPVIQKLNPIWEKWILTRTETPPTLPRTRR
>NC_019753.1|WP_083890050.1|649781_650471_+|D-alanyl-D-alanine-dipeptidase
MKRCIGADQKRRTDAIAITLQNYGKSAGISPVENYRQSNIIQPTTTKPKNSNTQLSDIQSVNKDIVVEMRYATADNFMGKKVYPVAKCLLKPTVAKKLSAVQQDLAPLGLGLKVYDCYRPLSIQKLMWEIKPDEDYVANPATGSRHNRGAAVDLTLVDSTGKELEMPSAFDDFTKKAHRNYTGSSVTARQNSLLLEAAMKRRNFTSIAKEWWHFDSPDWKKFPVMDLPL
>NC_019753.1|WP_015201655.1|647875_648799_+|hypothetical-protein
MQGYRSIDLLAELPIDVQYQELKEREQYEQQKQLLQELNQQKYSNAVARGRFLLFLINLGMIAVIALPTANQWATKVTGLADVIPEVLQSIPTIPELFERTERNSPKSQKIASAIINYAQQKNWVIRTGARKYNIFYVRGMNPDGTLNDNKVNEFNDLRVVIEIVNNTPRIVGLWEGTDAPGTHYIRNPMNPAGAATIVAGRQYRAWKMGFHKGNPNHPALVQTGGTVTVTRNGGSPYAGYFGINQHGGYDYPRNDIKDASAACLLGRTRAGHAKFMNLLELDADYVNDHNYTFYSGFILGKDLFVF
>NC_019753.1|WP_015201654.1|647555_647906_+|hypothetical-protein
MRWIIFPKRSILITTAIGTLLILDLIKPGYRQFALIPELKPQVLDVATDFSQTASKFGQDATNSLITTQNSNSVASSPVKSKSQIKELKPCATLLEGYKKNSKGEPVCRGIAQSTY
>NC_019753.1|WP_015201653.1|647108_647495_+|four-helix-bundle-protein
MEKQPIKSHEDLEVYQMAFDSAMTIFELSKKFPVEERYSLTDQIRRSSRSVCANLAEAWRKRRYEAAFIAKLNDSESEAAETQTWIKFAVKCNYLDVEIGREIYATYNRILGILVTIINNPSPWLIKR
>NC_019753.1|WP_015201652.1|646406_647015_+|hypothetical-protein
MDSSLVPQQRVRNPGTEFGGQDSYIDIEYHYVRENAHEQAVRRAQQELHQAKQRLKKMERNIGPAMQSGSCAAIDVAGQFVHNSKPWRLGQVVGFWSMLIGLCTIGGWAWNAAVGGTAAAGNSAALPANAPTAMKFGHGVVNVGKPVAGAVFAGASQSVDRGVRVQLTGSAEQVRNVAVPTNVTPSSSTFVPVVPIANYAGQ
>NC_019753.1|WP_015201651.1|644771_646244_+|ATP-binding-protein
MQLTTIAKLAIAPVSLISGLGLLGASFTTTQITQTVTPYSSEQVIVNQPLAEPVKSLLMFGGSAIAVIGSVGGIFAGIEDHRRRIGIQQTNFTQANSYPQLPFAPTPALPLNPQPGQSLRRSPVQQPQQPVQPGQGFQRQPAQVPPRNPANQQLQRQVPPNQQRQAPSPAERLPIRYPKPSSSNSTASNNSGNPPVPQPTEFLDVFDEIRKILLNIPTLLIYGGMGSGKTSKGGWLAAEHLKLGHLVLLVNPLAQWKFFEGIKTYGKGENFKDAAEGIMRFVKEANRRLQLRGISDYNPFSEQHWVLLCDEMTNWEANMPTVVMAALIEVCTQKLRQANMSVIFTSHGKTLTCFGGRSAGNGKFDVLKRQFTMMRCIAKSDPNVEGGKTCAGYAHLEWLDDEDKEATRKLTIPTGMVPPNKQVTPNGQTWYDFRPLLPAQPESAESDDDIINKELDDDETQEKLSTFSEFIKENDLRLENFQPPDEWGDI
>NC_019753.1|WP_015201650.1|643680_644655_+|hypothetical-protein
MNQNNNWRDRYADALDLGERPQQEYIEYDLFDQEPTGNQQIVWMPGEGPVPVYNPNSITSFPWESYLTNSWLMAGVVGILTTLLVTVLATTTNQKNQAVAPVDNTLANINQANYVLTQSRSAEVVAVTKYDYNPGEVTNPGLLQRAIFTSADGFKTRIQQLQASSNPATKDQPKEILVQRARVDVMKTIDMGASGRGAVMVREDPATGKTTYSQLDPAETVAVGLVRLLIIEASQRNNFQTFNLPEIAVAIRGHQGILRDAQANLLGAQGWVDVANQLRNYDLYGQKIIPNINSDSSTPTPPISSPKKEEGKKGTRGGGDKETK
>NC_019753.1|WP_015201649.1|643446_643647_+|hypothetical-protein
MTNAGILAIGTSVSIPAVTTTMALATTQTAPNFLQVSSAAIGGTVIGVTLGICILRSHYRQITNQS
>NC_019753.1|WP_015201648.1|642625_643393_+|hypothetical-protein
MELLVKTLAESIKSTEQELRSALSTLGFQIASKKRQNVVSGTVKHALLLDNTEITADKATKELAAIALEFSKTIDEVATFIAEYKAPENGDATDMSEISESASTIEDEIELEELKEETLSAIDTAEQAILQREANENTTFGDLGGLILEADLVMKLQQGRARAWENPNTRKALEGLIKQGSQHKLATLLGKPMTNGVMKLKSLTNILKPTLTVNITSTEVENKLPAVRTAAPSKLLAQASTSTPNSTTTATLPTG
>NC_019753.1|WP_157462253.1|659668_659836_-|hypothetical-protein
MIILFSSEAFPPTSMILISWLALLTHPAASLANSEVNSALLTGLISSARCSELQT
>NC_019753.1|WP_051035335.1|659834_660161_+|hypothetical-protein
MAEATHAVILSGDESKFADWEEFCQKLNLRIIAKIKSNLEAEMDEVNMSSNWKEKAKKIASKEQSQILQLEDWLLLTGKVHRLTRGEDVSSSPMVKALPELMIHLTKY
>NC_019753.1|WP_015201659.1|660857_662537_+|hypothetical-protein
MYLVLIETSGNQNFIFSTNKLRENIGASELTYRACTRWVLEAVAQVNNSRGISLWTTDGRQLGRNLFNKQLNQQIESANNRVEVIIATSGKALLIAKDEETAKTLIRYVTKKAVIEAPGLEICGVFQEFNWEEDLIGKVNSEVHQKYELVRSQKPSNNLRFTRLPVITDCATSGLPAGELFPNPEPNEKPISTSAVSAAKQRCSEGASNRMIALLEGGDRFSEDIDDIKSDWIAIIHADGNGLGEIFLKFHEHISADRPNKNRDYIDKLRKFSLCLDICTERAFNTALDQIKPFIEINNNLIPLVPLVLGGDDLTVVCDGKFALKFTQEFLKAFEQETASITHYEGIIPEIAKTALKVGRLSACAGIAIIKPHFPFSVGYDLSEALMKSAKKIKKIVVNDAEKPYPCSSLDFHVLYDSSNVNFEKIRGKLHLDGGKTQLYVRPYVVTEINNLSNAKQGLEWANFHHWQKLENSVKVLVDKDLEGRRKLPNSQMHDLRESLFLGKNAADGKFQLICDRYHDNGISQLAGDENSLFSLEPDLGIYKTILLDAIEAADFLIV
>NC_019753.1|WP_041226273.1|662600_664913_+|hypothetical-protein
MISDWHVGSGTGISGDIDKLVQRDTDGLPYIPAKTLTGIWRDACEIVARGLDNGTNGNWSKWVEYLFGEQPAVAKGAIETPPRPAALSIRSAYLPDNLRQALKQKLELKNAVTFVKPGISIDPESGCAKQDFLRFEEMVRGGTSLNAKCELTLPQNPEQQLAAYALLIAGGQFIERLGGKRRRGAGKCKLAVEKDINPWINWLQQHPQAPPIPDLDVERRDTAPGKVENQTDNSWVSVKLRVKTESPVIISKRTVGNVVESLDYIPGTHLLRLVRRRLSKLNLNIDPAIACGQIIVTNATVEIDNQQGKPVPLCLFSEKATGGLSKGGKIYNRFVENEPEGQLKGERAGYINFQSQTIKHKTVNLCIDTHNTVEDQYQRPTSDVGGVYSYQAIQSNTILQAEIRLCSSLAKELSKQRSDWWNLLKGSDRIGQSKKDNYGAVRLEVLGNPAQLSANTDVNNSHELTVLLLSDVLLRDERLRPTTSIDCLAAELAKLLEVDKLTIRKDKDNKLSLMARQNRIDSWQVRWGLPRPSLVGLSAGSCMVFTVEGNLDPNKLAEITARGIGDRRSEGYGQICFNHPLITLATSNLQVAGEVQLNSSSIRPELIKPSDLTFNYARIIEREAWREAIRKTCLFLVSSEQSRAHILGIKITRSDDELKSEPPMSQLGGLRSILSRLQTVTDANRAIAWLVSLEATPNRKDKWSKTDDALGKIRNLISNQNRVWQILNIDSAKITLTATGQQDLKNELWAEAVRTLVDACIRAHKRDCEG
>NC_019753.1|WP_015201661.1|664920_666450_+|hypothetical-protein
MARKIDSRIKVTGTLIAQSPIHVGGINDNPEVDLTIAVNGQGHYYIPGTSLAGAFRNWMQMYTGSEHFINGLWGFQEKKGGNNGHASFILIEDAIVQGAVLEIRDGVGINRFSGTAAEQAKYDRAILTRGSKINLDITFEVTSKASADWSKYQKLFFQLIDALQHGEIRLGAAKTRGLGKVKLLNAKVIEQDLLTHSGIIQALQNQGNVLNLSQLTNQITISSANPILDIVINWTPQSPLMVKAEGDGIAVDILPLVSAVDSSVTFVLPGSSVKGTLRSQAERIIRTVRNLTIPNDSNNGQTFIQQVEVALVKDIFGTAAKNEGENQFGKIGSLSVDDCYANIPISVNDWENIKSATNETNLIQVLNRANLTNTQQVFHVAVDRWTGGAAEGFLYTTLEPMGISWQPLRLSLNLGRLESNSLPALALLLLVLRDLSQRKIPLGYATNRGMGAIKVDSISIQGRNLDEALSAFLPATLNNGNIATLHRKFLDQLNKAWQQWIELPTTNNG
>NC_019753.1|WP_015201662.1|666442_667027_+|TIGR03984-family-CRISPR-associated-protein
MVNLHGRTTNNITLLEALKNCANALAKNSHAVALLYSPDWCKFGYLQFDGNLVDSKGTSFDLSSVFEAKVFNDKAELRWLNELNGVGKAVLISEADISSCLTDNINILTAIDTNEQCYLLWGEKVRSLSTPGWTRLAAARIGAIDVPVSSQTDEARIYLQTLEYLGEDEYGNVAVVEERLIRLIEKRVIKSEVK
>NC_019753.1|WP_015201663.1|667026_669369_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MTIGTLVLVGKNKNLQVKFTNANGKEVYMPIPEAELSAPVVAKKRNAIAQLEGLEVELEVLNGQPKQVREKGKIFERPQANNAGSRQQQAIQRNPNPLPNRMNNATSANIRGDFHNPYNFIPAPPRKTDHPTLGDSRPVGHGCYHNNYWSGKITVTLTTVTPLLIPDAANLEKDDKGHKTYPVRVGVDGKPYLPPTSIKGMLRSAYEAVTNSRFGIFEKHNDRLAYRMEAKVTNVPARVERQGESLVLRIMEESSLLGNAAKLPRYQKPGSPPDKGERTAALKYDQSNQLPQHGDAVWVQINITGEVTRIIRRNGNSSPGNNWKKGWVCVTGANINGKKYERVFIEDNNNLKINVTEPIKALWRELITNYQETHIKDVEKRRDRNPPQSPQDYLGHKPGDTAWSRHIYTESEKELREGTLCYVELQGNQVTGLMPVTISRRLYNIAPEKLLDLSLHPATDMSQLSPADRVFGWVNQKGKGAYKGNLRISTVQCNTDDAIEPFSEPGVPLAILGQPKPQQARFYVAQDPKGTPLAANTGKQSGYLSNYGLRGRKVYPHHQDLPSNYWDNPTQDRTQIENNHHFQEYRRPKLRNVEQRDDQNRSILGWVKPSVQFSFEIDVTNLSDVELGALVWLLSLSENYHHHLGGGKPLGFGSVHLVINWQQSDLRQGQDWQQFYSDLLSNDNAKNEQARFTVETFKQQLTAAYSSGNQFDQIPFIKAFCVAAQGFTDGNPIHYPRLTPELNPNGEAFKWFVENERTNGLKMSLPELASDRGLPFKPSI
>NC_019753.1|WP_015201664.1|672071_673214_-|CRISPR-associated-protein
MSRVVISTIGTSLLTNQINRNTENNWYSRLRDTANITFKEIADQHPDVTEIIQVLQTRGKAKIDTDDINLIRSASAELNGIYGLYKGRLETGKEQRDIHWLITTDTYQGITTAQIVKNFLQKRGIIVDIYAPRQLSTASSESFSNGIDDLISWLDNNIYPYKQSHYQICFNLVGSFKSLQGYLNTIGMFYADEIIYIFEGKNSELITIPRLPISIDYTAIAPYKLQLALMDAGAVMNAEIVRGIHESMIYPPGKSELTLSTWGQLVWNQCKKEMLSQELLPFERLQYRPSFVADYKNIRSQDEKVKLQETLAKVSYLLNQSNGDTSVLKKDGGLQYDKYTNKGNIEHFRVTQGLRISCVAISGMLELRRYGAEPVVNNNP
>NC_019753.1|WP_015201665.1|673232_674420_-|CRISPR-associated-endoribonuclease-Cas6
MSLTKRTRQPSTTKTNAALAVRSQKASAKPQLATLDPLTFPVDTEIVGIVLELAPQTTAKLNPQYTTRLHAWFLDQVRRYNPDLSAYLHDGESEKPFTISGLHGALVSRGKEWEITAGETYRWYVTVLSRPVVEWLANWLQAPPPEIVLETATLPIEAIAISHPPTTYTELFTADRPNPPTITLSFLTPTSFRRKKHHFPLPTPVNVFHSYLRRWNDFAGNKFDQEDFLAWIDEGAIIHHHRLESVKVTAGKKGSVTGFTGAIEYGLSSSAQKHTEYQQLFYALGRLAPYCGTGHKTTFGLGQTRWGWQISEDIASPPSIQTVLAQRIAELTEIFIAQRRRTGGDRAHQIAEIWATILARREMGESLQAIATDLEMPYETVKTYAKLSRRALKSE
>NC_019753.1|WP_041225888.1|675374_675920_+|hypothetical-protein
MQSKTMKDLKNFLPLHLYGKGQAKDYSSLLQEIEKKESQIIWDNNRPIRLIKVCRVRVICGDQELYEDRQVFSDGRVRKRGIRGLAEKLFKDEKEEIAAKRALKEELGLSDEASTLVSIHFNGIDNEEKESPSYPGLKTRYLFWDFIAYLPVQYWQEEFVEGCEDDVKQTYFVWRKIADNN

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Crispr_ID: NC_019753_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_3

657331-657509

TypeIII

Consensus_repeat	Method
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CRISPRCasFinder

2 spacers

csx3,cas10,csm3gr7,csx19,csm6,cas6

The CRISPR arrays of NC_019753_3

>merge|NC_019753|3|657331-657509|CRISPRCasFinder
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACCTTTAGCTTTTTCCAAATGATTTTCACCTGAAAAAACCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAACGTGAATCTTTTTTTTTGGCCAGCTTCCAGTTTACCTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC

>NC_019753|3|2|657331-657509|CRISPRCasFinder
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	CTTTAGCTTTTTCCAAATGATTTTCACCTGAAAAAAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC	GTGAATCTTTTTTTTTGGCCAGCTTCCAGTTTAC
CTTCCACTAACCATTTCCCCGTAAGGGGACGGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_157462253.1\|659668_659836_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201655.1\|647875_648799_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_041225881.1\|652413_652923_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201652.1\|646406_647015_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201659.1\|660857_662537_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|224272
NC_019753.1\|WP_015201665.1\|673232_674420_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NC_019753.1\|WP_041226273.1\|662600_664913_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|377130
NC_019753.1\|WP_015201648.1\|642625_643393_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201650.1\|643680_644655_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201653.1\|647108_647495_+\|four-helix-bundle-protein	unknown	unknown	gnl\|CDD\|377534
NC_019753.1\|WP_015201651.1\|644771_646244_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223021
NC_019753.1\|WP_015201663.1\|667026_669369_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NC_019753.1\|WP_041225888.1\|675374_675920_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_051035335.1\|659834_660161_+\|hypothetical-protein	csx3	mkCas0115_csx3_CAS-I:CAS-III	unknown
NC_019753.1\|WP_015201662.1\|666442_667027_+\|TIGR03984-family-CRISPR-associated-protein	csx19	cls001376_csx19_CAS-III-D	gnl\|CDD\|274900
NC_019753.1\|WP_083890050.1\|649781_650471_+\|D-alanyl-D-alanine-dipeptidase	unknown	unknown	gnl\|CDD\|350617
NC_019753.1\|WP_015201661.1\|664920_666450_+\|hypothetical-protein	csm3gr7	cd09683_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187857
NC_019753.1\|WP_015201649.1\|643446_643647_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201664.1\|672071_673214_-\|CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NC_019753.1\|WP_015201654.1\|647555_647906_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015201663.1\|667026_669369_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	1.31148e-103
NC_019753.1\|WP_015201664.1\|672071_673214_-\|CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	1.26278e-44
NC_019753.1\|WP_015201659.1\|660857_662537_+\|hypothetical-protein	gnl\|CDD\|224272	COG1353, COG1353, Predicted CRISPR-associated polymerase [Defense mechanisms].	0.00100674
NC_019753.1\|WP_015201662.1\|666442_667027_+\|TIGR03984-family-CRISPR-associated-protein	gnl\|CDD\|274900	TIGR03984, hypothetical_protein_FrEUN1fDRAFT_5778, CRISPR-associated protein, TIGR03984 family. Members of this protein family are found exclusively in CRISPR-containing organisms, in operon contexts with RAMP (repeat-associated mystery protein) proteins also linked to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats).	1.82726e-32
NC_019753.1\|WP_083890050.1\|649781_650471_+\|D-alanyl-D-alanine-dipeptidase	gnl\|CDD\|350617	cd14840, D-Ala-D-Ala_dipeptidase_Aad, D-Ala-D-Ala dipeptidase (includes Lactobacillus plantarum Aad peptidase). D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. This subfamily includes Lactobacillus Aad peptidase and belongs in the MEROPS peptidase family M15, subfamily D.	5.93405e-99
NC_019753.1\|WP_041226273.1\|662600_664913_+\|hypothetical-protein	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	5.21522e-18
NC_019753.1\|WP_015201661.1\|664920_666450_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	4.08546e-18
NC_019753.1\|WP_015201665.1\|673232_674420_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	9.13429e-34
NC_019753.1\|WP_015201653.1\|647108_647495_+\|four-helix-bundle-protein	gnl\|CDD\|377534	pfam05635, 23S_rRNA_IVP, 23S rRNA-intervening sequence protein. This family consists of bacterial proteins encoded within an intervening sequence present within some 23S rRNA genes. It folds into an anti-parallel four-helix bundle and forms homopentamers.	7.47783e-36
NC_019753.1\|WP_015201651.1\|644771_646244_+\|ATP-binding-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	3.52127e-05

>NC_019753.1|WP_041225881.1|652413_652923_+|hypothetical-protein
MTSQLTFWLPGKCSPKVRPRATVINQSHSVSIKKSKAHVYNCPRYTAWKNWAISSLYRQFLNQNKSYKQEPLEHIEILIVFIGKHRGDGENMVGAVLDSAVQANIITDDCLKNIPKGCWEHKEATDPKITGTLILIKPIEPVIQKLNPIWEKWILTRTETPPTLPRTRR
>NC_019753.1|WP_083890050.1|649781_650471_+|D-alanyl-D-alanine-dipeptidase
MKRCIGADQKRRTDAIAITLQNYGKSAGISPVENYRQSNIIQPTTTKPKNSNTQLSDIQSVNKDIVVEMRYATADNFMGKKVYPVAKCLLKPTVAKKLSAVQQDLAPLGLGLKVYDCYRPLSIQKLMWEIKPDEDYVANPATGSRHNRGAAVDLTLVDSTGKELEMPSAFDDFTKKAHRNYTGSSVTARQNSLLLEAAMKRRNFTSIAKEWWHFDSPDWKKFPVMDLPL
>NC_019753.1|WP_015201655.1|647875_648799_+|hypothetical-protein
MQGYRSIDLLAELPIDVQYQELKEREQYEQQKQLLQELNQQKYSNAVARGRFLLFLINLGMIAVIALPTANQWATKVTGLADVIPEVLQSIPTIPELFERTERNSPKSQKIASAIINYAQQKNWVIRTGARKYNIFYVRGMNPDGTLNDNKVNEFNDLRVVIEIVNNTPRIVGLWEGTDAPGTHYIRNPMNPAGAATIVAGRQYRAWKMGFHKGNPNHPALVQTGGTVTVTRNGGSPYAGYFGINQHGGYDYPRNDIKDASAACLLGRTRAGHAKFMNLLELDADYVNDHNYTFYSGFILGKDLFVF
>NC_019753.1|WP_015201654.1|647555_647906_+|hypothetical-protein
MRWIIFPKRSILITTAIGTLLILDLIKPGYRQFALIPELKPQVLDVATDFSQTASKFGQDATNSLITTQNSNSVASSPVKSKSQIKELKPCATLLEGYKKNSKGEPVCRGIAQSTY
>NC_019753.1|WP_015201653.1|647108_647495_+|four-helix-bundle-protein
MEKQPIKSHEDLEVYQMAFDSAMTIFELSKKFPVEERYSLTDQIRRSSRSVCANLAEAWRKRRYEAAFIAKLNDSESEAAETQTWIKFAVKCNYLDVEIGREIYATYNRILGILVTIINNPSPWLIKR
>NC_019753.1|WP_015201652.1|646406_647015_+|hypothetical-protein
MDSSLVPQQRVRNPGTEFGGQDSYIDIEYHYVRENAHEQAVRRAQQELHQAKQRLKKMERNIGPAMQSGSCAAIDVAGQFVHNSKPWRLGQVVGFWSMLIGLCTIGGWAWNAAVGGTAAAGNSAALPANAPTAMKFGHGVVNVGKPVAGAVFAGASQSVDRGVRVQLTGSAEQVRNVAVPTNVTPSSSTFVPVVPIANYAGQ
>NC_019753.1|WP_015201651.1|644771_646244_+|ATP-binding-protein
MQLTTIAKLAIAPVSLISGLGLLGASFTTTQITQTVTPYSSEQVIVNQPLAEPVKSLLMFGGSAIAVIGSVGGIFAGIEDHRRRIGIQQTNFTQANSYPQLPFAPTPALPLNPQPGQSLRRSPVQQPQQPVQPGQGFQRQPAQVPPRNPANQQLQRQVPPNQQRQAPSPAERLPIRYPKPSSSNSTASNNSGNPPVPQPTEFLDVFDEIRKILLNIPTLLIYGGMGSGKTSKGGWLAAEHLKLGHLVLLVNPLAQWKFFEGIKTYGKGENFKDAAEGIMRFVKEANRRLQLRGISDYNPFSEQHWVLLCDEMTNWEANMPTVVMAALIEVCTQKLRQANMSVIFTSHGKTLTCFGGRSAGNGKFDVLKRQFTMMRCIAKSDPNVEGGKTCAGYAHLEWLDDEDKEATRKLTIPTGMVPPNKQVTPNGQTWYDFRPLLPAQPESAESDDDIINKELDDDETQEKLSTFSEFIKENDLRLENFQPPDEWGDI
>NC_019753.1|WP_015201650.1|643680_644655_+|hypothetical-protein
MNQNNNWRDRYADALDLGERPQQEYIEYDLFDQEPTGNQQIVWMPGEGPVPVYNPNSITSFPWESYLTNSWLMAGVVGILTTLLVTVLATTTNQKNQAVAPVDNTLANINQANYVLTQSRSAEVVAVTKYDYNPGEVTNPGLLQRAIFTSADGFKTRIQQLQASSNPATKDQPKEILVQRARVDVMKTIDMGASGRGAVMVREDPATGKTTYSQLDPAETVAVGLVRLLIIEASQRNNFQTFNLPEIAVAIRGHQGILRDAQANLLGAQGWVDVANQLRNYDLYGQKIIPNINSDSSTPTPPISSPKKEEGKKGTRGGGDKETK
>NC_019753.1|WP_015201649.1|643446_643647_+|hypothetical-protein
MTNAGILAIGTSVSIPAVTTTMALATTQTAPNFLQVSSAAIGGTVIGVTLGICILRSHYRQITNQS
>NC_019753.1|WP_015201648.1|642625_643393_+|hypothetical-protein
MELLVKTLAESIKSTEQELRSALSTLGFQIASKKRQNVVSGTVKHALLLDNTEITADKATKELAAIALEFSKTIDEVATFIAEYKAPENGDATDMSEISESASTIEDEIELEELKEETLSAIDTAEQAILQREANENTTFGDLGGLILEADLVMKLQQGRARAWENPNTRKALEGLIKQGSQHKLATLLGKPMTNGVMKLKSLTNILKPTLTVNITSTEVENKLPAVRTAAPSKLLAQASTSTPNSTTTATLPTG
>NC_019753.1|WP_157462253.1|659668_659836_-|hypothetical-protein
MIILFSSEAFPPTSMILISWLALLTHPAASLANSEVNSALLTGLISSARCSELQT
>NC_019753.1|WP_051035335.1|659834_660161_+|hypothetical-protein
MAEATHAVILSGDESKFADWEEFCQKLNLRIIAKIKSNLEAEMDEVNMSSNWKEKAKKIASKEQSQILQLEDWLLLTGKVHRLTRGEDVSSSPMVKALPELMIHLTKY
>NC_019753.1|WP_015201659.1|660857_662537_+|hypothetical-protein
MYLVLIETSGNQNFIFSTNKLRENIGASELTYRACTRWVLEAVAQVNNSRGISLWTTDGRQLGRNLFNKQLNQQIESANNRVEVIIATSGKALLIAKDEETAKTLIRYVTKKAVIEAPGLEICGVFQEFNWEEDLIGKVNSEVHQKYELVRSQKPSNNLRFTRLPVITDCATSGLPAGELFPNPEPNEKPISTSAVSAAKQRCSEGASNRMIALLEGGDRFSEDIDDIKSDWIAIIHADGNGLGEIFLKFHEHISADRPNKNRDYIDKLRKFSLCLDICTERAFNTALDQIKPFIEINNNLIPLVPLVLGGDDLTVVCDGKFALKFTQEFLKAFEQETASITHYEGIIPEIAKTALKVGRLSACAGIAIIKPHFPFSVGYDLSEALMKSAKKIKKIVVNDAEKPYPCSSLDFHVLYDSSNVNFEKIRGKLHLDGGKTQLYVRPYVVTEINNLSNAKQGLEWANFHHWQKLENSVKVLVDKDLEGRRKLPNSQMHDLRESLFLGKNAADGKFQLICDRYHDNGISQLAGDENSLFSLEPDLGIYKTILLDAIEAADFLIV
>NC_019753.1|WP_041226273.1|662600_664913_+|hypothetical-protein
MISDWHVGSGTGISGDIDKLVQRDTDGLPYIPAKTLTGIWRDACEIVARGLDNGTNGNWSKWVEYLFGEQPAVAKGAIETPPRPAALSIRSAYLPDNLRQALKQKLELKNAVTFVKPGISIDPESGCAKQDFLRFEEMVRGGTSLNAKCELTLPQNPEQQLAAYALLIAGGQFIERLGGKRRRGAGKCKLAVEKDINPWINWLQQHPQAPPIPDLDVERRDTAPGKVENQTDNSWVSVKLRVKTESPVIISKRTVGNVVESLDYIPGTHLLRLVRRRLSKLNLNIDPAIACGQIIVTNATVEIDNQQGKPVPLCLFSEKATGGLSKGGKIYNRFVENEPEGQLKGERAGYINFQSQTIKHKTVNLCIDTHNTVEDQYQRPTSDVGGVYSYQAIQSNTILQAEIRLCSSLAKELSKQRSDWWNLLKGSDRIGQSKKDNYGAVRLEVLGNPAQLSANTDVNNSHELTVLLLSDVLLRDERLRPTTSIDCLAAELAKLLEVDKLTIRKDKDNKLSLMARQNRIDSWQVRWGLPRPSLVGLSAGSCMVFTVEGNLDPNKLAEITARGIGDRRSEGYGQICFNHPLITLATSNLQVAGEVQLNSSSIRPELIKPSDLTFNYARIIEREAWREAIRKTCLFLVSSEQSRAHILGIKITRSDDELKSEPPMSQLGGLRSILSRLQTVTDANRAIAWLVSLEATPNRKDKWSKTDDALGKIRNLISNQNRVWQILNIDSAKITLTATGQQDLKNELWAEAVRTLVDACIRAHKRDCEG
>NC_019753.1|WP_015201661.1|664920_666450_+|hypothetical-protein
MARKIDSRIKVTGTLIAQSPIHVGGINDNPEVDLTIAVNGQGHYYIPGTSLAGAFRNWMQMYTGSEHFINGLWGFQEKKGGNNGHASFILIEDAIVQGAVLEIRDGVGINRFSGTAAEQAKYDRAILTRGSKINLDITFEVTSKASADWSKYQKLFFQLIDALQHGEIRLGAAKTRGLGKVKLLNAKVIEQDLLTHSGIIQALQNQGNVLNLSQLTNQITISSANPILDIVINWTPQSPLMVKAEGDGIAVDILPLVSAVDSSVTFVLPGSSVKGTLRSQAERIIRTVRNLTIPNDSNNGQTFIQQVEVALVKDIFGTAAKNEGENQFGKIGSLSVDDCYANIPISVNDWENIKSATNETNLIQVLNRANLTNTQQVFHVAVDRWTGGAAEGFLYTTLEPMGISWQPLRLSLNLGRLESNSLPALALLLLVLRDLSQRKIPLGYATNRGMGAIKVDSISIQGRNLDEALSAFLPATLNNGNIATLHRKFLDQLNKAWQQWIELPTTNNG
>NC_019753.1|WP_015201662.1|666442_667027_+|TIGR03984-family-CRISPR-associated-protein
MVNLHGRTTNNITLLEALKNCANALAKNSHAVALLYSPDWCKFGYLQFDGNLVDSKGTSFDLSSVFEAKVFNDKAELRWLNELNGVGKAVLISEADISSCLTDNINILTAIDTNEQCYLLWGEKVRSLSTPGWTRLAAARIGAIDVPVSSQTDEARIYLQTLEYLGEDEYGNVAVVEERLIRLIEKRVIKSEVK
>NC_019753.1|WP_015201663.1|667026_669369_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MTIGTLVLVGKNKNLQVKFTNANGKEVYMPIPEAELSAPVVAKKRNAIAQLEGLEVELEVLNGQPKQVREKGKIFERPQANNAGSRQQQAIQRNPNPLPNRMNNATSANIRGDFHNPYNFIPAPPRKTDHPTLGDSRPVGHGCYHNNYWSGKITVTLTTVTPLLIPDAANLEKDDKGHKTYPVRVGVDGKPYLPPTSIKGMLRSAYEAVTNSRFGIFEKHNDRLAYRMEAKVTNVPARVERQGESLVLRIMEESSLLGNAAKLPRYQKPGSPPDKGERTAALKYDQSNQLPQHGDAVWVQINITGEVTRIIRRNGNSSPGNNWKKGWVCVTGANINGKKYERVFIEDNNNLKINVTEPIKALWRELITNYQETHIKDVEKRRDRNPPQSPQDYLGHKPGDTAWSRHIYTESEKELREGTLCYVELQGNQVTGLMPVTISRRLYNIAPEKLLDLSLHPATDMSQLSPADRVFGWVNQKGKGAYKGNLRISTVQCNTDDAIEPFSEPGVPLAILGQPKPQQARFYVAQDPKGTPLAANTGKQSGYLSNYGLRGRKVYPHHQDLPSNYWDNPTQDRTQIENNHHFQEYRRPKLRNVEQRDDQNRSILGWVKPSVQFSFEIDVTNLSDVELGALVWLLSLSENYHHHLGGGKPLGFGSVHLVINWQQSDLRQGQDWQQFYSDLLSNDNAKNEQARFTVETFKQQLTAAYSSGNQFDQIPFIKAFCVAAQGFTDGNPIHYPRLTPELNPNGEAFKWFVENERTNGLKMSLPELASDRGLPFKPSI
>NC_019753.1|WP_015201664.1|672071_673214_-|CRISPR-associated-protein
MSRVVISTIGTSLLTNQINRNTENNWYSRLRDTANITFKEIADQHPDVTEIIQVLQTRGKAKIDTDDINLIRSASAELNGIYGLYKGRLETGKEQRDIHWLITTDTYQGITTAQIVKNFLQKRGIIVDIYAPRQLSTASSESFSNGIDDLISWLDNNIYPYKQSHYQICFNLVGSFKSLQGYLNTIGMFYADEIIYIFEGKNSELITIPRLPISIDYTAIAPYKLQLALMDAGAVMNAEIVRGIHESMIYPPGKSELTLSTWGQLVWNQCKKEMLSQELLPFERLQYRPSFVADYKNIRSQDEKVKLQETLAKVSYLLNQSNGDTSVLKKDGGLQYDKYTNKGNIEHFRVTQGLRISCVAISGMLELRRYGAEPVVNNNP
>NC_019753.1|WP_015201665.1|673232_674420_-|CRISPR-associated-endoribonuclease-Cas6
MSLTKRTRQPSTTKTNAALAVRSQKASAKPQLATLDPLTFPVDTEIVGIVLELAPQTTAKLNPQYTTRLHAWFLDQVRRYNPDLSAYLHDGESEKPFTISGLHGALVSRGKEWEITAGETYRWYVTVLSRPVVEWLANWLQAPPPEIVLETATLPIEAIAISHPPTTYTELFTADRPNPPTITLSFLTPTSFRRKKHHFPLPTPVNVFHSYLRRWNDFAGNKFDQEDFLAWIDEGAIIHHHRLESVKVTAGKKGSVTGFTGAIEYGLSSSAQKHTEYQQLFYALGRLAPYCGTGHKTTFGLGQTRWGWQISEDIASPPSIQTVLAQRIAELTEIFIAQRRRTGGDRAHQIAEIWATILARREMGESLQAIATDLEMPYETVKTYAKLSRRALKSE
>NC_019753.1|WP_041225888.1|675374_675920_+|hypothetical-protein
MQSKTMKDLKNFLPLHLYGKGQAKDYSSLLQEIEKKESQIIWDNNRPIRLIKVCRVRVICGDQELYEDRQVFSDGRVRKRGIRGLAEKLFKDEKEEIAAKRALKEELGLSDEASTLVSIHFNGIDNEEKESPSYPGLKTRYLFWDFIAYLPVQYWQEEFVEGCEDDVKQTYFVWRKIADNN

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Crispr_ID: NC_019753_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_4

669542-671689

TypeIII

Consensus_repeat	Method
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CRISPRCasFinder
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CRT
GTCTCGAATCCACTTTCCCCGCAAGGGGACGGAAAC	PILER-CR

28 spacers

csm3gr7,csx19,cas10,csx3,csm6,cas6,WYL

The CRISPR arrays of NC_019753_4

>merge|NC_019753|4|669542-671689|CRISPRCasFinder,CRT,PILER-CR
CTTTTCGTCCCCTTGCGGGGAAAGTGGATTCGAGACGTAGTTACCAAAGTAACCAACCTTTACCGTACTTTACGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACAAATCTCTGGAAAAACTATATAAAGTACGTGAAATTTGTTTCGAGAAAGGAGCGGTTGGGGGTTGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTTTACTGGCAGCAATTGGTTGTATATTGCTGGGATTATCGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTTACAACATCACAAACAACAAATTTCTAATATAATTAGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTCTTCAAATTTAGAAATGGAAGTACTTTCCGTTGAATGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACGCGGTAACGTCTATTCCGGTAGCGGAGCAAATAACATGAAGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTGCTAAAGCGGATGATCCAAACAGCGAATTGAATAGTCTGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACCTTTCAAGTTGGAATCTGGGAGAGTTTCAAACAGCAATGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTAGTAACCCAAAAGATTTGTTAGGGTCAAAGAGTGACGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACAATTTTTTGGACTCGCCTTCCCTTTACCCGACGATTTACCGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACGAATATGATCTCTGCATATATTTTCCCAAAGAATTTAAGGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACAATTTATTTTGAATCTTTTGACAACGTTTTAGGCGAACCAACAAGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTACTAATTTTGTTGATGCTCGCCAGCGTCCGCGTTCGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACCGAGAAAGTCAAATTCTTGATGCGGTTGAAAAAAACCGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACGTAACTGCCGCTGGGGAACGTTATTATGTTCCTTCAGAAGACGGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTCTGGTGATCAAAAGCAACCATCTCAACGGGATATTAAGAGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACCTCTGGAAGTGGCTGGTGCAATCAGCAACCAACTCCGGGTGGTAATCGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTCTAAAGGTTGAACTAAATCGAAAAGGGAGTCAAACGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTCTTAAACGCGGATTAACATGGTTCCTGGAATATATAGAAAATGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACGCAAGTTCAAAGTACGTATTTTCCTTAGGAGAAAAAGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTTGGCTTCACTCCTAATGTGAAAGCAGACGAAAGTATGGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACGTGCAGGTTGCACAGGGTTTGGATCTTCAACTTCGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTCTTGCAAGCTACACAGCTCAGCAAGTTAGGAAGCTAGAGAGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACCTCTTTTATAGAGATTTGTAAAACCAGCGTTTTTATGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACATTACAGGACTTTTTGAACCTGCATACCAATGAAACGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTTTTAAGAATGGGGGTAACAATCCGGGAACTCCGCGTAGAGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACTCAAAAACATTGTTTACTTTGCAGCATGGAAAATGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGACAGTTCCACCCTGGCTGGACATTATTTTTCCTAAAGCGTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC

>NC_019753|4|3|669542-671689|CRISPRCasFinder
CTTTTCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GTAGTTACCAAAGTAACCAACCTTTACCGTACTTTAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AAATCTCTGGAAAAACTATATAAAGTACGTGAAATTTGTTTCGAGAAAGGAGCGGTTGGGGGTT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTTACTGGCAGCAATTGGTTGTATATTGCTGGGATTATC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTACAACATCACAAACAACAAATTTCTAATATAATTA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTTCAAATTTAGAAATGGAAGTACTTTCCGTTGAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GCGGTAACGTCTATTCCGGTAGCGGAGCAAATAACATGAA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TGCTAAAGCGGATGATCCAAACAGCGAATTGAATAGTCT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CTTTCAAGTTGGAATCTGGGAGAGTTTCAAACAGCAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TAGTAACCCAAAAGATTTGTTAGGGTCAAAGAGTGAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AATTTTTTGGACTCGCCTTCCCTTTACCCGACGATTTACC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GAATATGATCTCTGCATATATTTTCCCAAAGAATTTAAG
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AATTTATTTTGAATCTTTTGACAACGTTTTAGGCGAACCAACAA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TACTAATTTTGTTGATGCTCGCCAGCGTCCGCGTTC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CGAGAAAGTCAAATTCTTGATGCGGTTGAAAAAAACC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GTAACTGCCGCTGGGGAACGTTATTATGTTCCTTCAGAAGACG
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTGGTGATCAAAAGCAACCATCTCAACGGGATATTAAGA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CTCTGGAAGTGGCTGGTGCAATCAGCAACCAACTCCGGGTGGTAATC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTAAAGGTTGAACTAAATCGAAAAGGGAGTCAAAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTTAAACGCGGATTAACATGGTTCCTGGAATATATAGAAAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GCAAGTTCAAAGTACGTATTTTCCTTAGGAGAAAAA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTGGCTTCACTCCTAATGTGAAAGCAGACGAAAGTATG
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GTGCAGGTTGCACAGGGTTTGGATCTTCAACTTC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTTGCAAGCTACACAGCTCAGCAAGTTAGGAAGCTAGAGA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CTCTTTTATAGAGATTTGTAAAACCAGCGTTTTTAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	ATTACAGGACTTTTTGAACCTGCATACCAATGAAAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTTTAAGAATGGGGGTAACAATCCGGGAACTCCGCGTAGA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCAAAAACATTGTTTACTTTGCAGCATGGAAAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AGTTCCACCCTGGCTGGACATTATTTTTCCTAAAGC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC

>NC_019753|4|2|669542-671689|CRT
CTTTTCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GTAGTTACCAAAGTAACCAACCTTTACCGTACTTTAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AAATCTCTGGAAAAACTATATAAAGTACGTGAAATTTGTTTCGAGAAAGGAGCGGTTGGGGGTT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTTACTGGCAGCAATTGGTTGTATATTGCTGGGATTATC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTACAACATCACAAACAACAAATTTCTAATATAATTA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTTCAAATTTAGAAATGGAAGTACTTTCCGTTGAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GCGGTAACGTCTATTCCGGTAGCGGAGCAAATAACATGAA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TGCTAAAGCGGATGATCCAAACAGCGAATTGAATAGTCT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CTTTCAAGTTGGAATCTGGGAGAGTTTCAAACAGCAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TAGTAACCCAAAAGATTTGTTAGGGTCAAAGAGTGAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AATTTTTTGGACTCGCCTTCCCTTTACCCGACGATTTACC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GAATATGATCTCTGCATATATTTTCCCAAAGAATTTAAG
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AATTTATTTTGAATCTTTTGACAACGTTTTAGGCGAACCAACAA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TACTAATTTTGTTGATGCTCGCCAGCGTCCGCGTTC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CGAGAAAGTCAAATTCTTGATGCGGTTGAAAAAAACC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GTAACTGCCGCTGGGGAACGTTATTATGTTCCTTCAGAAGACG
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTGGTGATCAAAAGCAACCATCTCAACGGGATATTAAGA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CTCTGGAAGTGGCTGGTGCAATCAGCAACCAACTCCGGGTGGTAATC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTAAAGGTTGAACTAAATCGAAAAGGGAGTCAAAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTTAAACGCGGATTAACATGGTTCCTGGAATATATAGAAAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GCAAGTTCAAAGTACGTATTTTCCTTAGGAGAAAAA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTGGCTTCACTCCTAATGTGAAAGCAGACGAAAGTATG
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GTGCAGGTTGCACAGGGTTTGGATCTTCAACTTC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTTGCAAGCTACACAGCTCAGCAAGTTAGGAAGCTAGAGA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CTCTTTTATAGAGATTTGTAAAACCAGCGTTTTTAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	ATTACAGGACTTTTTGAACCTGCATACCAATGAAAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTTTAAGAATGGGGGTAACAATCCGGGAACTCCGCGTAGA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCAAAAACATTGTTTACTTTGCAGCATGGAAAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AGTTCCACCCTGGCTGGACATTATTTTTCCTAAAGC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC

>NC_019753|4|3|669715-671689|PILER-CR
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTTACTGGCAGCAATTGGTTGTATATTGCTGGGATTATC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTACAACATCACAAACAACAAATTTCTAATATAATTA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTTCAAATTTAGAAATGGAAGTACTTTCCGTTGAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GCGGTAACGTCTATTCCGGTAGCGGAGCAAATAACATGAA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TGCTAAAGCGGATGATCCAAACAGCGAATTGAATAGTCT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CTTTCAAGTTGGAATCTGGGAGAGTTTCAAACAGCAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TAGTAACCCAAAAGATTTGTTAGGGTCAAAGAGTGAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AATTTTTTGGACTCGCCTTCCCTTTACCCGACGATTTACC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GAATATGATCTCTGCATATATTTTCCCAAAGAATTTAAG
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AATTTATTTTGAATCTTTTGACAACGTTTTAGGCGAACCAACAA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TACTAATTTTGTTGATGCTCGCCAGCGTCCGCGTTC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CGAGAAAGTCAAATTCTTGATGCGGTTGAAAAAAACC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GTAACTGCCGCTGGGGAACGTTATTATGTTCCTTCAGAAGACG
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTGGTGATCAAAAGCAACCATCTCAACGGGATATTAAGA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CTCTGGAAGTGGCTGGTGCAATCAGCAACCAACTCCGGGTGGTAATC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTAAAGGTTGAACTAAATCGAAAAGGGAGTCAAAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTTAAACGCGGATTAACATGGTTCCTGGAATATATAGAAAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GCAAGTTCAAAGTACGTATTTTCCTTAGGAGAAAAA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTGGCTTCACTCCTAATGTGAAAGCAGACGAAAGTATG
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	GTGCAGGTTGCACAGGGTTTGGATCTTCAACTTC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCTTGCAAGCTACACAGCTCAGCAAGTTAGGAAGCTAGAGA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	CTCTTTTATAGAGATTTGTAAAACCAGCGTTTTTAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	ATTACAGGACTTTTTGAACCTGCATACCAATGAAAC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TTTTAAGAATGGGGGTAACAATCCGGGAACTCCGCGTAGA
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	TCAAAAACATTGTTTACTTTGCAGCATGGAAAAT
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC	AGTTCCACCCTGGCTGGACATTATTTTTCCTAAAGC
GTTTCCGTCCCCTTGCGGGGAAAGTGGATTCGAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_157462253.1\|659668_659836_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201655.1\|647875_648799_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_041225881.1\|652413_652923_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201667.1\|676207_677257_-\|DegT/DnrJ/EryC1/StrS-aminotransferase	unknown	unknown	gnl\|CDD\|99740
NC_019753.1\|WP_015201672.1\|682774_684331_-\|TIGR03985-family-CRISPR-associated-protein	WYL	mkCas0075_WYL_CAS-I:CAS-III	gnl\|CDD\|274901
NC_019753.1\|WP_015201659.1\|660857_662537_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|224272
NC_019753.1\|WP_015201669.1\|679270_680137_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201662.1\|666442_667027_+\|TIGR03984-family-CRISPR-associated-protein	csx19	cls001376_csx19_CAS-III-D	gnl\|CDD\|274900
NC_019753.1\|WP_015201665.1\|673232_674420_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NC_019753.1\|WP_015201671.1\|681371_682220_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368559
NC_019753.1\|WP_015201663.1\|667026_669369_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NC_019753.1\|WP_041225888.1\|675374_675920_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_051035335.1\|659834_660161_+\|hypothetical-protein	csx3	mkCas0115_csx3_CAS-I:CAS-III	unknown
NC_019753.1\|WP_041226273.1\|662600_664913_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|377130
NC_019753.1\|WP_083890050.1\|649781_650471_+\|D-alanyl-D-alanine-dipeptidase	unknown	unknown	gnl\|CDD\|350617
NC_019753.1\|WP_083890051.1\|684968_685748_+\|CRISPR-associated-protein-Csx3	csx3	mkCas0115_csx3_CAS-I:CAS-III	unknown
NC_019753.1\|WP_015201668.1\|677288_679061_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|365803
NC_019753.1\|WP_015201670.1\|680352_681369_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274033
NC_019753.1\|WP_015201664.1\|672071_673214_-\|CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NC_019753.1\|WP_015201661.1\|664920_666450_+\|hypothetical-protein	csm3gr7	cd09683_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187857

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015201670.1\|680352_681369_-\|hypothetical-protein	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	0.00385257
NC_019753.1\|WP_015201667.1\|676207_677257_-\|DegT/DnrJ/EryC1/StrS-aminotransferase	gnl\|CDD\|99740	cd00616, AHBA_syn, 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.	3.71988e-52
NC_019753.1\|WP_015201672.1\|682774_684331_-\|TIGR03985-family-CRISPR-associated-protein	gnl\|CDD\|274901	TIGR03985, hypothetical_protein_sll7078, CRISPR-associated protein, TIGR03985 family. Members of this protein family belong to CRISPR-associated (Cas) gene clusters. The majority of members are Cyanobacterial.	1.74857e-97
NC_019753.1\|WP_015201659.1\|660857_662537_+\|hypothetical-protein	gnl\|CDD\|224272	COG1353, COG1353, Predicted CRISPR-associated polymerase [Defense mechanisms].	0.00100674
NC_019753.1\|WP_015201662.1\|666442_667027_+\|TIGR03984-family-CRISPR-associated-protein	gnl\|CDD\|274900	TIGR03984, hypothetical_protein_FrEUN1fDRAFT_5778, CRISPR-associated protein, TIGR03984 family. Members of this protein family are found exclusively in CRISPR-containing organisms, in operon contexts with RAMP (repeat-associated mystery protein) proteins also linked to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats).	1.82726e-32
NC_019753.1\|WP_015201665.1\|673232_674420_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	9.13429e-34
NC_019753.1\|WP_015201671.1\|681371_682220_-\|hypothetical-protein	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	0.00443144
NC_019753.1\|WP_015201663.1\|667026_669369_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	1.31148e-103
NC_019753.1\|WP_015201668.1\|677288_679061_-\|ATP-binding-protein	gnl\|CDD\|365803	pfam00004, AAA, ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.	2.04813e-15
NC_019753.1\|WP_041226273.1\|662600_664913_+\|hypothetical-protein	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	5.21522e-18
NC_019753.1\|WP_083890050.1\|649781_650471_+\|D-alanyl-D-alanine-dipeptidase	gnl\|CDD\|350617	cd14840, D-Ala-D-Ala_dipeptidase_Aad, D-Ala-D-Ala dipeptidase (includes Lactobacillus plantarum Aad peptidase). D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. This subfamily includes Lactobacillus Aad peptidase and belongs in the MEROPS peptidase family M15, subfamily D.	5.93405e-99
NC_019753.1\|WP_015201664.1\|672071_673214_-\|CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	1.26278e-44
NC_019753.1\|WP_015201661.1\|664920_666450_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	4.08546e-18

>NC_019753.1|WP_015201663.1|667026_669369_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MTIGTLVLVGKNKNLQVKFTNANGKEVYMPIPEAELSAPVVAKKRNAIAQLEGLEVELEVLNGQPKQVREKGKIFERPQANNAGSRQQQAIQRNPNPLPNRMNNATSANIRGDFHNPYNFIPAPPRKTDHPTLGDSRPVGHGCYHNNYWSGKITVTLTTVTPLLIPDAANLEKDDKGHKTYPVRVGVDGKPYLPPTSIKGMLRSAYEAVTNSRFGIFEKHNDRLAYRMEAKVTNVPARVERQGESLVLRIMEESSLLGNAAKLPRYQKPGSPPDKGERTAALKYDQSNQLPQHGDAVWVQINITGEVTRIIRRNGNSSPGNNWKKGWVCVTGANINGKKYERVFIEDNNNLKINVTEPIKALWRELITNYQETHIKDVEKRRDRNPPQSPQDYLGHKPGDTAWSRHIYTESEKELREGTLCYVELQGNQVTGLMPVTISRRLYNIAPEKLLDLSLHPATDMSQLSPADRVFGWVNQKGKGAYKGNLRISTVQCNTDDAIEPFSEPGVPLAILGQPKPQQARFYVAQDPKGTPLAANTGKQSGYLSNYGLRGRKVYPHHQDLPSNYWDNPTQDRTQIENNHHFQEYRRPKLRNVEQRDDQNRSILGWVKPSVQFSFEIDVTNLSDVELGALVWLLSLSENYHHHLGGGKPLGFGSVHLVINWQQSDLRQGQDWQQFYSDLLSNDNAKNEQARFTVETFKQQLTAAYSSGNQFDQIPFIKAFCVAAQGFTDGNPIHYPRLTPELNPNGEAFKWFVENERTNGLKMSLPELASDRGLPFKPSI
>NC_019753.1|WP_015201662.1|666442_667027_+|TIGR03984-family-CRISPR-associated-protein
MVNLHGRTTNNITLLEALKNCANALAKNSHAVALLYSPDWCKFGYLQFDGNLVDSKGTSFDLSSVFEAKVFNDKAELRWLNELNGVGKAVLISEADISSCLTDNINILTAIDTNEQCYLLWGEKVRSLSTPGWTRLAAARIGAIDVPVSSQTDEARIYLQTLEYLGEDEYGNVAVVEERLIRLIEKRVIKSEVK
>NC_019753.1|WP_015201661.1|664920_666450_+|hypothetical-protein
MARKIDSRIKVTGTLIAQSPIHVGGINDNPEVDLTIAVNGQGHYYIPGTSLAGAFRNWMQMYTGSEHFINGLWGFQEKKGGNNGHASFILIEDAIVQGAVLEIRDGVGINRFSGTAAEQAKYDRAILTRGSKINLDITFEVTSKASADWSKYQKLFFQLIDALQHGEIRLGAAKTRGLGKVKLLNAKVIEQDLLTHSGIIQALQNQGNVLNLSQLTNQITISSANPILDIVINWTPQSPLMVKAEGDGIAVDILPLVSAVDSSVTFVLPGSSVKGTLRSQAERIIRTVRNLTIPNDSNNGQTFIQQVEVALVKDIFGTAAKNEGENQFGKIGSLSVDDCYANIPISVNDWENIKSATNETNLIQVLNRANLTNTQQVFHVAVDRWTGGAAEGFLYTTLEPMGISWQPLRLSLNLGRLESNSLPALALLLLVLRDLSQRKIPLGYATNRGMGAIKVDSISIQGRNLDEALSAFLPATLNNGNIATLHRKFLDQLNKAWQQWIELPTTNNG
>NC_019753.1|WP_041226273.1|662600_664913_+|hypothetical-protein
MISDWHVGSGTGISGDIDKLVQRDTDGLPYIPAKTLTGIWRDACEIVARGLDNGTNGNWSKWVEYLFGEQPAVAKGAIETPPRPAALSIRSAYLPDNLRQALKQKLELKNAVTFVKPGISIDPESGCAKQDFLRFEEMVRGGTSLNAKCELTLPQNPEQQLAAYALLIAGGQFIERLGGKRRRGAGKCKLAVEKDINPWINWLQQHPQAPPIPDLDVERRDTAPGKVENQTDNSWVSVKLRVKTESPVIISKRTVGNVVESLDYIPGTHLLRLVRRRLSKLNLNIDPAIACGQIIVTNATVEIDNQQGKPVPLCLFSEKATGGLSKGGKIYNRFVENEPEGQLKGERAGYINFQSQTIKHKTVNLCIDTHNTVEDQYQRPTSDVGGVYSYQAIQSNTILQAEIRLCSSLAKELSKQRSDWWNLLKGSDRIGQSKKDNYGAVRLEVLGNPAQLSANTDVNNSHELTVLLLSDVLLRDERLRPTTSIDCLAAELAKLLEVDKLTIRKDKDNKLSLMARQNRIDSWQVRWGLPRPSLVGLSAGSCMVFTVEGNLDPNKLAEITARGIGDRRSEGYGQICFNHPLITLATSNLQVAGEVQLNSSSIRPELIKPSDLTFNYARIIEREAWREAIRKTCLFLVSSEQSRAHILGIKITRSDDELKSEPPMSQLGGLRSILSRLQTVTDANRAIAWLVSLEATPNRKDKWSKTDDALGKIRNLISNQNRVWQILNIDSAKITLTATGQQDLKNELWAEAVRTLVDACIRAHKRDCEG
>NC_019753.1|WP_015201659.1|660857_662537_+|hypothetical-protein
MYLVLIETSGNQNFIFSTNKLRENIGASELTYRACTRWVLEAVAQVNNSRGISLWTTDGRQLGRNLFNKQLNQQIESANNRVEVIIATSGKALLIAKDEETAKTLIRYVTKKAVIEAPGLEICGVFQEFNWEEDLIGKVNSEVHQKYELVRSQKPSNNLRFTRLPVITDCATSGLPAGELFPNPEPNEKPISTSAVSAAKQRCSEGASNRMIALLEGGDRFSEDIDDIKSDWIAIIHADGNGLGEIFLKFHEHISADRPNKNRDYIDKLRKFSLCLDICTERAFNTALDQIKPFIEINNNLIPLVPLVLGGDDLTVVCDGKFALKFTQEFLKAFEQETASITHYEGIIPEIAKTALKVGRLSACAGIAIIKPHFPFSVGYDLSEALMKSAKKIKKIVVNDAEKPYPCSSLDFHVLYDSSNVNFEKIRGKLHLDGGKTQLYVRPYVVTEINNLSNAKQGLEWANFHHWQKLENSVKVLVDKDLEGRRKLPNSQMHDLRESLFLGKNAADGKFQLICDRYHDNGISQLAGDENSLFSLEPDLGIYKTILLDAIEAADFLIV
>NC_019753.1|WP_051035335.1|659834_660161_+|hypothetical-protein
MAEATHAVILSGDESKFADWEEFCQKLNLRIIAKIKSNLEAEMDEVNMSSNWKEKAKKIASKEQSQILQLEDWLLLTGKVHRLTRGEDVSSSPMVKALPELMIHLTKY
>NC_019753.1|WP_157462253.1|659668_659836_-|hypothetical-protein
MIILFSSEAFPPTSMILISWLALLTHPAASLANSEVNSALLTGLISSARCSELQT
>NC_019753.1|WP_041225881.1|652413_652923_+|hypothetical-protein
MTSQLTFWLPGKCSPKVRPRATVINQSHSVSIKKSKAHVYNCPRYTAWKNWAISSLYRQFLNQNKSYKQEPLEHIEILIVFIGKHRGDGENMVGAVLDSAVQANIITDDCLKNIPKGCWEHKEATDPKITGTLILIKPIEPVIQKLNPIWEKWILTRTETPPTLPRTRR
>NC_019753.1|WP_083890050.1|649781_650471_+|D-alanyl-D-alanine-dipeptidase
MKRCIGADQKRRTDAIAITLQNYGKSAGISPVENYRQSNIIQPTTTKPKNSNTQLSDIQSVNKDIVVEMRYATADNFMGKKVYPVAKCLLKPTVAKKLSAVQQDLAPLGLGLKVYDCYRPLSIQKLMWEIKPDEDYVANPATGSRHNRGAAVDLTLVDSTGKELEMPSAFDDFTKKAHRNYTGSSVTARQNSLLLEAAMKRRNFTSIAKEWWHFDSPDWKKFPVMDLPL
>NC_019753.1|WP_015201655.1|647875_648799_+|hypothetical-protein
MQGYRSIDLLAELPIDVQYQELKEREQYEQQKQLLQELNQQKYSNAVARGRFLLFLINLGMIAVIALPTANQWATKVTGLADVIPEVLQSIPTIPELFERTERNSPKSQKIASAIINYAQQKNWVIRTGARKYNIFYVRGMNPDGTLNDNKVNEFNDLRVVIEIVNNTPRIVGLWEGTDAPGTHYIRNPMNPAGAATIVAGRQYRAWKMGFHKGNPNHPALVQTGGTVTVTRNGGSPYAGYFGINQHGGYDYPRNDIKDASAACLLGRTRAGHAKFMNLLELDADYVNDHNYTFYSGFILGKDLFVF
>NC_019753.1|WP_015201664.1|672071_673214_-|CRISPR-associated-protein
MSRVVISTIGTSLLTNQINRNTENNWYSRLRDTANITFKEIADQHPDVTEIIQVLQTRGKAKIDTDDINLIRSASAELNGIYGLYKGRLETGKEQRDIHWLITTDTYQGITTAQIVKNFLQKRGIIVDIYAPRQLSTASSESFSNGIDDLISWLDNNIYPYKQSHYQICFNLVGSFKSLQGYLNTIGMFYADEIIYIFEGKNSELITIPRLPISIDYTAIAPYKLQLALMDAGAVMNAEIVRGIHESMIYPPGKSELTLSTWGQLVWNQCKKEMLSQELLPFERLQYRPSFVADYKNIRSQDEKVKLQETLAKVSYLLNQSNGDTSVLKKDGGLQYDKYTNKGNIEHFRVTQGLRISCVAISGMLELRRYGAEPVVNNNP
>NC_019753.1|WP_015201665.1|673232_674420_-|CRISPR-associated-endoribonuclease-Cas6
MSLTKRTRQPSTTKTNAALAVRSQKASAKPQLATLDPLTFPVDTEIVGIVLELAPQTTAKLNPQYTTRLHAWFLDQVRRYNPDLSAYLHDGESEKPFTISGLHGALVSRGKEWEITAGETYRWYVTVLSRPVVEWLANWLQAPPPEIVLETATLPIEAIAISHPPTTYTELFTADRPNPPTITLSFLTPTSFRRKKHHFPLPTPVNVFHSYLRRWNDFAGNKFDQEDFLAWIDEGAIIHHHRLESVKVTAGKKGSVTGFTGAIEYGLSSSAQKHTEYQQLFYALGRLAPYCGTGHKTTFGLGQTRWGWQISEDIASPPSIQTVLAQRIAELTEIFIAQRRRTGGDRAHQIAEIWATILARREMGESLQAIATDLEMPYETVKTYAKLSRRALKSE
>NC_019753.1|WP_041225888.1|675374_675920_+|hypothetical-protein
MQSKTMKDLKNFLPLHLYGKGQAKDYSSLLQEIEKKESQIIWDNNRPIRLIKVCRVRVICGDQELYEDRQVFSDGRVRKRGIRGLAEKLFKDEKEEIAAKRALKEELGLSDEASTLVSIHFNGIDNEEKESPSYPGLKTRYLFWDFIAYLPVQYWQEEFVEGCEDDVKQTYFVWRKIADNN
>NC_019753.1|WP_015201667.1|676207_677257_-|DegT/DnrJ/EryC1/StrS-aminotransferase
MVKIDELISWQQIHLSGTGEVAALESKLKQYYGMQYALCVTNATTGLWAIALALGLQNQQFVTTPYTYGATLASWLFLGNQPIFADIEPDTLSLSCEAVRQVITPKTKALLAVDLFGIPSDTVALRQLASEYGLWYVADAAQSLGATRGGLPASLLADALVVSFTTGKTVFAGEGGAILTNHADLYEKLIWYTQHPIRQHLELGLYLDNEFAINGRIHPLAAVLANATFEESLQNLQVHQQECFQVIELLNSLGLTEDIDFANQGINPSFFRLTATLKDSTQISTLLKILQSHGFRGSLESPPVRLIYRQPSFLAQYQHKCQQHFCCPQAEYQSVNRFCIASNEKLNYR
>NC_019753.1|WP_015201668.1|677288_679061_-|ATP-binding-protein
MATKAIEAIVTPYEEGFPAILVTGRSLYDFDLHTDGKVRPLIEILRQVLRARYGMLLVTYSLATGLDYDASRINDQRDRTTIETTLQSHQLLNIPQDQNEVVRVIRGIYSLSRTPTNGLKWADGRDLRFAFLFEFTEHLTPGCLTNGTQTDTQLVAIELSHITAQSLALRSSGNLMIFHGREGQVDELVSSALYHIRLPQPDLKDKKDFLAATTSLYTAAKFATGMSVESVAYLTTNTPNRGLESLLRAAHRSGRELTVKELVAQKSRDVETLSEHTLTVLDTERVNDLQLRGFNIAKPRLILERYAAALVAGDRSMPANVLLTGPPGTGKTDLAILTARQAAVAAYQMHSPKGSLVGETERKVRLQQMVLQESIPNIAFIDEVTEALPLERSEFDGDSGASRAVTAALLTALSDESRRGQSLLIATTNCPWRMGAAMRSRFTIIPVLHPLKADFPGIILATASRITTPRELSENDPQIIKAAEIFYQKGANPRQIRSALSNALMLHGSLTSDTVLFAAMDLNVSSDLVSAIYADLWAIKACSSQSFFPWTPPHYPFPPHLEDIVDPITLKINQVELDRRIDELRPHANL
>NC_019753.1|WP_015201669.1|679270_680137_-|hypothetical-protein
MSSISSRPRVQSVSLNTVAKNAVFTSQVITSAVNFLSSQAVKAYKQVAQSLQLSTVNTIEPVASLRAEYQLQQQQITTALSPYNLSATESIQLTALLTAAPYVVESNLKIQQPLQALQLSTEPSAARQAQNLLLQAVEASHHQVFLETLKVACTNAAVQIGFTSVQTMASLVGTVRLVATDAQGRSLVTEINGDINSQPSIATEVVGVSDGSCNAILDEFDRALEAAGVRAAVPTRKFTGGVCELAAAREFVRKKVKPQSTSRVTNTNSPNDKRRIQRLNQGNTTQQQ
>NC_019753.1|WP_015201670.1|680352_681369_-|hypothetical-protein
MPDNFQVGKQRLDRERRTNVLDQGLKGIHKHSHIAARAQKNNQEARQARHNQESDYSEFNQAGLRRINGYFFLILAIPAAYFMDFVILNRPVEYLVGLVFPEESKMMLVAKILMPLAILGLELYIATQLYFALVGEAPQRLWKNIAHCMVIVMPVMVIVTFVPQHFKVFQTSSWWIYALLLIALTILAGITHALVIFGGETAYEARSYFWFLWTNKRYRRIERQQDAKYRSEAAAGYAILTSYINNLNTFNRLYPEHAITAGPFDDITYRIMNQWAGYEILQRPGKPNNNPPHNPAPSPPNTPPTNNDEDATEEDGKNEYLRTILSSRIRSEESEVRP
>NC_019753.1|WP_015201671.1|681371_682220_-|hypothetical-protein
MKHNQIALLLLLLLPACQVSPDSTSVIKSPTSNPKPIIAGVPSELQPDTNKLQVNTRPLKIVVEIDKSLSTNQTKVQQPKWQDFQPLLQKLRQIGGELAIGTICNNSNQSFIRLRLEKPLTLPQKPIEPSNNINPLKLPELQAEYEKKLTAYQQQLQADQQQQQQWEQNNTTKIKQFQTKLQLLLNKSVACTRTDIWNAVNRADLFLAENDASWGQSTNRIAVLISDGIDDVKAKFLPMKSKAKVILVNGSANIGSLTSLNPELFESTPAAFRYIIATNGGK
>NC_019753.1|WP_015201672.1|682774_684331_-|TIGR03985-family-CRISPR-associated-protein
MRTQFAYSPSVSFLQMLAPGSSKQNLPKAVRLWVILRSLYGSDNDEVKLNLREQFTYDEWRNQFFTSSDPLNKRSLDEVIYHKRDQVPLLHDPSCRCAKTLRQWLFDPNSSLSISPEKWKQSFLQIYPIDIAQLEEFLLTGKFPKSEEAIEKRRQQSNSLKASKNQLTGKQRNYVPPFPEGRLFAVTGKNLEYDFENLIKIGWLEAVKNKKNEVINKNYRKVKKFPILESYNWNSNISGFITQTDFTEIVENYFQPINGIQRFLMHVDYVVSKEAIDRIRELQDQLKEIWEKTPIPPISIIYESASLARQGKRIIYPVCIYYFQRAPYLCAFGQKPKIKNEIEWHNYRLDRIHEITELTWNDENLPVLLKEKYYQQQLSPEEIQTKMAESWGFDFYQPSHKLLLRFDRDFHDRHIIDSFRHETFTYINSKANFKKFIRDYAPNQEEEKLLNDILQSLPVQQTDENFPYAYYTADYRINDNNVIMRLRAWGQKVEVLLPGDLRQRMAKDIEETWQLYQS
>NC_019753.1|WP_083890051.1|684968_685748_+|CRISPR-associated-protein-Csx3
MNGRATVLASFLIAYEVGHKYGAVAVFDPKIGDRGLDRYIVTINHSKNYQVGETFDINYQPQPNVKVVLCGPANTGKTVFKDGLKAAILKLNHAPDDFYVISGCPDGDGSWHGETAQKYPKLAEELKAEYKAKFTPEFAQGKARDIKAIKNSLLVFDVGGKISDENITIMSEATHAVILAKTPEDVAQWQNFCEIKLERPLPIIAIIYSDYAGKEDKIITEEPVLTGSVHYLERGQNVSNRPMIKALAELLVSLAINCR

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Crispr_ID: NC_019753_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_5

831026-831188

TypeV

Consensus_repeat	Method
CAGAGTTGATGGAAATCCCTTTTTGGCAAGCAATGATTAGAGAAGATATTTC	CRISPRCasFinder

1 spacers

cas14j

The CRISPR arrays of NC_019753_5

>merge|NC_019753|5|831026-831188|CRISPRCasFinder
CAGAGTTGATGGAAATCCCTTTTTGGCAAGCAATGATTAGAGAAGATATTTCTGCTTATACAGCCAAACAGTTTTTTTACGATTACGATACAGAAAATTGGCAAGACTTAACAGAGTTGATGGAAATCCCTTTTTGGCAAGCGATGATTAGAGAAGATATTTC

>NC_019753|5|4|831026-831188|CRISPRCasFinder
CAGAGTTGATGGAAATCCCTTTTTGGCAAGCAATGATTAGAGAAGATATTTC	TGCTTATACAGCCAAACAGTTTTTTTACGATTACGATACAGAAAATTGGCAAGACTTAA
CAGAGTTGATGGAAATCCCTTTTTGGCAAGCGATGATTAGAGAAGATATTTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015201781.1\|820332_821058_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|293795
NC_019753.1\|WP_015201788.1\|828893_830102_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	cas14j	-	gnl\|CDD\|223747
NC_019753.1\|WP_015201787.1\|827715_828192_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_019753.1\|WP_015201784.1\|824703_825732_+\|dihydroorotase	unknown	unknown	gnl\|CDD\|235474
NC_019753.1\|WP_015201800.1\|846592_847660_+\|NAD/NADP-octopine/nopaline-dehydrogenase	unknown	unknown	gnl\|CDD\|376763
NC_019753.1\|WP_015201780.1\|819123_819534_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350315
NC_019753.1\|WP_015201792.1\|834078_834744_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187586
NC_019753.1\|WP_015201785.1\|825848_826853_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NC_019753.1\|WP_015201779.1\|818890_819121_+\|prevent-host-death-family-protein	unknown	unknown	gnl\|CDD\|226603
NC_019753.1\|WP_015201786.1\|826896_827643_-\|coenzyme-F420-dependent-NADP-oxidoreductase	unknown	unknown	gnl\|CDD\|224996
NC_019753.1\|WP_015201782.1\|821706_822609_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187569
NC_019753.1\|WP_015201796.1\|840236_840698_+\|DUF2786-domain-containing-protein	unknown	unknown	gnl\|CDD\|378525
NC_019753.1\|WP_015201790.1\|831753_832962_+\|glutathione-gamma-glutamylcysteinyltransferase	unknown	unknown	gnl\|CDD\|368247
NC_019753.1\|WP_015201791.1\|833101_833905_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NC_019753.1\|WP_015201778.1\|817587_818688_-\|ISAs1-family-transposase	unknown	unknown	gnl\|CDD\|379382
NC_019753.1\|WP_015201799.1\|844725_846207_-\|glycerol-kinase-GlpK	unknown	unknown	gnl\|CDD\|198361
NC_019753.1\|WP_015201795.1\|837131_838253_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201793.1\|834869_835850_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381305
NC_019753.1\|WP_015201794.1\|836096_836918_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201797.1\|840878_843101_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|237354

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015201781.1\|820332_821058_+\|hypothetical-protein	gnl\|CDD\|293795	cd07709, flavodiiron_proteins_MBL-fold, catalytic domain of flavodiiron proteins (FDPs) and related proteins; MBL-fold metallo-hydrolase domain. FDPs catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively. In addition to this N-terminal catalytic domain they contain a C-terminal flavin mononucleotide-binding flavodoxin-like domain. Although some FDPs are able to reduce NO or O2 with similar catalytic efficiencies others are selective for either NO or O2, such as Escherichia coli flavorubredoxin which is selective toward NO and G. intestinalis FDP which is selective toward O2. These enzymes belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Some members of this subgroup are single domain.	2.01327e-40
NC_019753.1\|WP_015201788.1\|828893_830102_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	7.21236e-55
NC_019753.1\|WP_015201787.1\|827715_828192_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.07548e-20
NC_019753.1\|WP_015201784.1\|824703_825732_+\|dihydroorotase	gnl\|CDD\|235474	PRK05451, PRK05451, dihydroorotase; Provisional.	0
NC_019753.1\|WP_015201800.1\|846592_847660_+\|NAD/NADP-octopine/nopaline-dehydrogenase	gnl\|CDD\|376763	pfam02317, Octopine_DH, NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain. This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.	6.37468e-38
NC_019753.1\|WP_015201780.1\|819123_819534_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350315	cd18748, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	8.68711e-85
NC_019753.1\|WP_015201792.1\|834078_834744_-\|SDR-family-oxidoreductase	gnl\|CDD\|187586	cd05325, carb_red_sniffer_like_SDR_c, carbonyl reductase sniffer-like, classical (c) SDRs. Sniffer is an NADPH-dependent carbonyl reductase of the classical SDR family. Studies in Drosophila melanogaster implicate Sniffer in the prevention of neurodegeneration due to aging and oxidative-stress. This subgroup also includes Rhodococcus sp. AD45 IsoH, which is an NAD-dependent 1-hydroxy-2-glutathionyl-2-methyl-3-butene dehydrogenase involved in isoprene metabolism, Aspergillus nidulans StcE encoded by a gene which is part of a proposed sterigmatocystin biosynthesis gene cluster, Bacillus circulans SANK 72073 BtrF encoded by a gene found in the butirosin biosynthesis gene cluster, and Aspergillus parasiticus nor-1 involved in the biosynthesis of aflatoxins. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.16189e-83
NC_019753.1\|WP_015201785.1\|825848_826853_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	2.55269e-166
NC_019753.1\|WP_015201779.1\|818890_819121_+\|prevent-host-death-family-protein	gnl\|CDD\|226603	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning].	0.00763552
NC_019753.1\|WP_015201786.1\|826896_827643_-\|coenzyme-F420-dependent-NADP-oxidoreductase	gnl\|CDD\|224996	COG2085, COG2085, Predicted dinucleotide-binding enzymes [General function prediction only].	1.8662e-34
NC_019753.1\|WP_015201782.1\|821706_822609_+\|NAD(P)H-binding-protein	gnl\|CDD\|187569	cd05259, PCBER_SDR_a, phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs. PCBER and pinoresinol-lariciresinol reductases are NADPH-dependent aromatic alcohol reductases, and are atypical members of the SDR family. Other proteins in this subgroup are identified as eugenol synthase. These proteins contain an N-terminus characteristic of NAD(P)-binding proteins and a small C-terminal domain presumed to be involved in substrate binding, but they do not have the conserved active site Tyr residue typically found in SDRs. Numerous other members have unknown functions. The glycine rich NADP-binding motif in this subgroup is of 2 forms: GXGXXG and G[GA]XGXXG; it tends to be atypical compared with the forms generally seen in classical or extended SDRs. The usual SDR active site tetrad is not present, but a critical active site Lys at the usual SDR position has been identified in various members, though other charged and polar residues are found at this position in this subgroup. Atypical SDR-related proteins retain the Rossmann fold of the SDRs, but have limited sequence identity and generally lack the catalytic properties of the archetypical members. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.80389e-39
NC_019753.1\|WP_015201796.1\|840236_840698_+\|DUF2786-domain-containing-protein	gnl\|CDD\|378525	pfam10979, DUF2786, Protein of unknown function (DUF2786). This family of proteins has no known function.	3.34695e-09
NC_019753.1\|WP_015201790.1\|831753_832962_+\|glutathione-gamma-glutamylcysteinyltransferase	gnl\|CDD\|368247	pfam05023, Phytochelatin, Phytochelatin synthase. Phytochelatin synthase is the enzyme responsible for the synthesis of heavy-metal-binding peptides (phytochelatins) from glutathione and related thiols. The crystal structure of a member of this family shows it to possess a papain fold. The enzyme catalyzes the deglycination of a GSH donor molecule. The enzyme contains a catalytic triad of cysteine, histidine and aspartate residues.	1.10324e-137
NC_019753.1\|WP_015201791.1\|833101_833905_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	2.39087e-64
NC_019753.1\|WP_015201778.1\|817587_818688_-\|ISAs1-family-transposase	gnl\|CDD\|379382	pfam13808, DDE_Tnp_1_assoc, DDE_Tnp_1-associated. This domain is frequently found N-terminal to the transposase, IS family DDE_Tnp_1, pfam01609 and its relatives.	3.3717e-27
NC_019753.1\|WP_015201799.1\|844725_846207_-\|glycerol-kinase-GlpK	gnl\|CDD\|198361	cd07786, FGGY_EcGK_like, Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases. This subgroup is composed of mostly bacterial and archaeal glycerol kinases (GK), including the well characterized proteins from Escherichia coli (EcGK), Thermococcus kodakaraensis (TkGK), and Enterococcus casseliflavus (EnGK). GKs contain two large domains separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The high affinity ATP binding site of EcGK is created only by a substrate-induced conformational change, which is initiated by protein-protein interactions through complex formation with enzyme IIAGlc (also known as IIIGlc), the glucose-specific phosphocarrier protein of the phosphotransferase system (PTS). EcGK exists in a dimer-tetramer equilibrium. IIAGlc binds to both EcGK dimer and tetramer, and inhibits the uptake and subsequent metabolism of glycerol and maltose. Another well-known allosteric regulator of EcGK is fructose 1,6-bisphosphate (FBP), which binds to the EcGK tetramer and plays an essential role in the stabilization of the inactive tetrameric form. EcGK requires Mg2+ for its enzymatic activity. Members in this subgroup belong to the FGGY family of carbohydrate kinases.	0
NC_019753.1\|WP_015201793.1\|834869_835850_-\|aldo/keto-reductase	gnl\|CDD\|381305	cd19079, AKR_EcYajO-like, Escherichia coli YajO and similar proteins. Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.	0
NC_019753.1\|WP_015201797.1\|840878_843101_+\|AAA-family-ATPase	gnl\|CDD\|237354	PRK13341, PRK13341, AAA family ATPase.	0

>NC_019753.1|WP_015201788.1|828893_830102_-|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MLDTLKVRIYPNKGQQEALAKSFGCSRFVFNYYLNKTNTQYEETGKGMSYCDMAKDLTQIKKLSDYEWLTEVTAATLQQTLKNLESAFKNFFSKRARFPKFKSKHRHQSIRYPESCSIKNGGLKLPKLGIVKASISRSINGKIKSVTVSQTSTDKYFAAILFETDDLATAKQGKISSIDLGLNSLVTVFDGEKFSKVDPIKPTRRYAKRLRRRQQALSRKKKGSLNRQKQVKRVARVHEKIANTRQDSLHKISRKLVDENQAIIAENLCIKGLARTKLAKSIHDAGFGMLLNFIGYKLEREGGIFLQVDRFFPSTKLCNGCKFKNNSLNLSVREWVCPECKIHHDRDENATQNLREEGIKILSTNTVGHTEIQACGEEVRLVGTCTKKRSSVKQESPVTAQA
>NC_019753.1|WP_015201787.1|827715_828192_-|MarR-family-transcriptional-regulator
MENRSNINERRQVARQLSFALYSASNRIIRLHKPFLEPLGLTYPQFLVMLALYEDTPRTVGDLGLELGMDNGTLTPLLKRLESAGLVTRTRDQQDERRVLIAITEAGEALREVACSIPEKIETACRLTHKDVVELRDTLDGLGIPLKTKAQEKDPPSN
>NC_019753.1|WP_015201786.1|826896_827643_-|coenzyme-F420-dependent-NADP-oxidoreductase
MKIGILGVGHIGKTLARKLSAAGHDVKVANSRGPETIEASVLASGARAVKTTEAVADVEVVILSIPLNRIPAIAPLIANLPAETAVIDTSNYYPHRDVGIDAIEAGQVESLWVVEQLGRPIVKAWNSIGSDSLAKRGKPAGSPDRIALPVAADRDPDRQVGMALVEDTGFDAFDAGTLADSWRQQPGAPCYGTDITRKEIPTALAATERARLPKRRDLAVAAIQERVGDGTTNPDAEYGIRLSRALYM
>NC_019753.1|WP_015201785.1|825848_826853_-|LLM-class-flavin-dependent-oxidoreductase
MTKLSVLDLVRIKQGGDARSALDDARDIATHLERWNYRRIWISEHHNSSGIASAATALVLAHIGAATSTIRLAAGGIMLPNHAPYVIAEQFGTLAQLFPGRVDLGLGRAPGTDQMAVRALRRPPQASDSFPQDVIELQTYFEPSSPGQRLVAAPADGTEVPLIILGSSLFGAALAGEVGLPYAFASHFAPDLLLDALRLYRERFKPSKQMDRPYAMVGVNVVAADTDYEARRLATSQQKSFADLFQHGTSGPLEPPINDIDDYWSPRAKAHAGRMLARSVVGGPTIVKEGLEALIQETSADELILVSDVYERAARLRSFEIVASVMGLTTQSLV
>NC_019753.1|WP_015201784.1|824703_825732_+|dihydroorotase
MQKLTITRPDDWHLHLRDGAALKAVLPHTVRQFARAIIMPNLKPPVRTVADAAAYRDRILAAIPDGQRFEPLMTLYLTDNTSPEEIIQAKESQFVKAVKYYPAGATTNSDLGVTDIRQCDRVFEAMQQVDLPLLLHGEVTDQDVDMFDREKAFIERHLIPLKQRFPNLRVVLEHVTTSDAVQYVLSANNIAATITPQHLLFNRNILFQGGIRPHFYCLPILKREEHRLALLQAATSGNPKFFLGTDSAPHPRNGKESSCGCAGCYSALHAMELYAEAFESVDALDQLEAFASFFGPDFYQLPRNTEQITLTRTTWRVPDEVPFTESGLVPLRAGQEMMWQMA
>NC_019753.1|WP_015201782.1|821706_822609_+|NAD(P)H-binding-protein
MGKTILIAGATGNLGGKIVDALLTHDANVRAIVRAETEPEKVSALRDKGVQVFQLDMFDKNKVAEVCAGAYCVVSALSGLRETVIDAQKALLDGAIEAHVPRFIPSVFSLDFTHLVSGTNRNLDWRREFEIYVDQAPIAATSIFNGAFMDLLTTDMPLILFRFRRILYWENLNVKMDLTTSDDVAQYAARVAIDADTPRHLRIAGDTVSAFDLKKIVSKATGKQFGLFCAGSIPLLEVIIQITRFFSPAENTLYPAWQGMQYMRDMMQGRAVVKAHDNHRYSDIGWTSVERFLARQNAKS
>NC_019753.1|WP_015201781.1|820332_821058_+|hypothetical-protein
MTTISEIAPDLYRISIYVPQLNLQFNQFLIKDTEPLLFHTGLKAMFPLVRDAIATLIDPSTLRWIGFSHFEADECGSLNEWLEVAPLAQPVCSLVGAMVSVNDFAIRPARAMQHNDILNTGKYCFQFQQTPHVPHCWEAGLLFETTHKTLLSSDLFTHSGNVEALIDSDITGRARQSLIEFEASPLANYMPYTQYTERILQQLAALKPQTLAIMHGSSFVGNGEQALQALAIQMREILSQA
>NC_019753.1|WP_015201780.1|819123_819534_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MTYLYLLDTNIISELIKNPRGVIFSKIQNVGEDTVCTSIIVACESRFGAEKKNSQKLTEKVEIILDSIEILPLTHPVEQYYAEIRTDLEQQGTPIGGNDLLIAAHCLSLGLTLVTNNVREFSRVPNLKVENWLNPN
>NC_019753.1|WP_015201779.1|818890_819121_+|prevent-host-death-family-protein
MKQITLTELPETVQNLINQAQQTGEQLTIMQNGVPFAIISPIQKKSLLQTLSTLEPLDEEFPDVDEGLLPLDDIEL
>NC_019753.1|WP_015201778.1|817587_818688_-|ISAs1-family-transposase
MLVSLIEHLKKVKDFRKSQGKRHPLWIVLLVVVLGMMSGYQGYREIGHFVKYEQRNLINNLEIFTERLPSCATIRRVMMGMDWQNLSEVFNQWAKENYPQIDETDWLAIDGKSLRSTVTNYADKSQNFGVIVSVFSQLTGLVIALSKIENKSKSEIAEVQDIVRNCGFKGKVISADALHCNQTTTRAIIKSQNNYLIALKKNQNKLYEQVKTLTNMIEPSSRCITKEQSHGRQVTREVTVFNNIIKLKNWSHIQSLIKVERWGWRGSSPYQETVYYISSMSADAETFNQRIRGHWRIENQVHWVKDVILNEDKMKIHQIQAATNFSILKTIVLNLFRGLGFISITEGKRWLGNHWNKLLIMTEELT
>NC_019753.1|WP_015201790.1|831753_832962_+|glutathione-gamma-glutamylcysteinyltransferase
MDAEGFYRRALPPQCIAFSSAQGRKIFAEALTLGGMEGYFALAEQFHTQVEPAFCGLGTLVVVLNALSIDPGRIWKGVWRWYGEEFLDCCKPLPVVKEEGITFDELACLARCNGAKVASYRSHQSSLEQFRQTIKEATSSPQDLHIIVSYSRQILGQTGDGHFSPVGGYHAERDLVLILDVARFKYPPHWVPLPLLWDALQPIDLVTGKGRGYMLLSKADTGNHTFYHVALDQYQWATVAPYFTKTLPQILAKNQPDSVIELVQTILQNLPPEFLTIVTNKINNKLLKLSSDVQGLWQQLLTEIHAHPLFAVIKTAKAASSNQENDPRFQWVSHQENLPDLLTMLLLSCPECLYFNLQEHLLNQVRELREVEQMSTLMRQEVIRLREQISALHELSLKLQIL
>NC_019753.1|WP_015201791.1|833101_833905_-|SDR-family-NAD(P)-dependent-oxidoreductase
MNRLITRPLAVVTGASNGIGYELAKQFAQNGFDLLVTATGATINQAAQDFEALGAKVETIQADLATYDGVEALYSKIKATGRPVEAIAINAGVGVGGEFAHETDLKDELNLINLNVVSSVHLAKRVVKDMVELGQGRILFTSSIAAIMPGPFEAVYAASKAFIHSFAEAIRNELKDTGVSVTSLMPGPTDTNFFHRAGMDDTKVGAKKNDDPAVVAKQGFEALMAGKDAVIAGSVMTQIQGNVSKVLPETLNAELHRHLTEPGSANK
>NC_019753.1|WP_015201792.1|834078_834744_-|SDR-family-oxidoreductase
MATYLVTGANRGIGYEYCRQLQARGNVVIAVCRQASDELKQLGVQLEEGVDITSDASVLHLRDRLGDTVIDALINNAGIIKRVTLEDLDFDNIRQQFEVNALGTLRVTHALLPLLKSGSKIVLMTSRMGSIADNTSGNSYGYRMSKVALSMAGKSLSIDLKPRGIAVAILHPGLVQTRMTNFTANGITAEESVKGLLARINELTLENTGTFWHANGEVLPW
>NC_019753.1|WP_015201793.1|834869_835850_-|aldo/keto-reductase
MKYIRLGNTGLKVSRICLGTMTYGSPKWREWVLPEEESRPFIKTSLEAGINFFDTADMYSLGESEAVLGRALKEFAKREQVVIATKVFNPMSDDPNDRGLSRKHIFDSIDASLRRLQTDYVDLYQIHRWDNETPICETLEALHDLVKVGKVRYIGASSMYAWQFAKALYLADLHGWTRFVSMQNHYNLVYREEEREMLPLCRAEGIGVIPWSPLARGFLAGNRQKETKGETTRAKTDDFAHQLYYQDSDFHVVDCVVELAKDRGVAPAQIALAWLLHQPGITAPIIGASKMSHLEDALAALEIELSNQECQSLEEFYQPHPVLGHQ
>NC_019753.1|WP_015201794.1|836096_836918_+|hypothetical-protein
MYNYNQTPNPGSPEIRRGQYFNYLVPSGWHVAEEGQFAVVLFAPDHAAFTLMVGNSGLPANYNPWQFVYDKLMGMQPVQLQINPPRQTQPISGYTVAYEFDYTYTFNGIPCQGLAKCSVAYSYNICTMVVTCAASHQSQWAGYASWLPQVAEQFTVTNGGAFGISGVIQQNREIAIAQGQQAREYREWQQRTWGEVNHQRHESIERQNFHFRENLGNVGTWTNPYGYPLAELPTSHQYYWINRQGQVYGTNDKSENPNVGSTQDWVRMNRYQP
>NC_019753.1|WP_015201795.1|837131_838253_-|hypothetical-protein
MSEYQYYEFQTIDRPLNNQEQELVSQISSRGQVSATRAVFTYSYGDFRGNHQEVLVKYFDAMFYIANWGTKQLMLRFPQSVLNIEHFHKYCVEDYITISFINKYAILDIRIEEEEGCGWIEEKSFLSAIVGLRNDLLNEDYCSLYLAWLKVITLPEVEIEENELEPPVPAGLNKLSGSLTAFKQLFEVDEYLLKAAAKVSHEPTLIPERALIAAIKKLTREECNEFLIRLAQKEANLSVALIRKLSTIVTAPIAQTQSRRSIKQLFKLSKQEQAEDAIQQKQAIEAQRLKELETLAQREMDAWEDVERLIQTSQARAYDQVVQLLLKLQDLATYHNQQNAFQIRLNKIYEQYSKRTALLQRLQKVRLYKQKVK
>NC_019753.1|WP_015201796.1|840236_840698_+|DUF2786-domain-containing-protein
MLDKTIIEKINKLLALATSSNENEAAVAAQKASLLLAQYNLSLADLGSQDLTDITELVVETTTRFISWKMLLLCGIAEANGCQAFRNNYNGNMRLIGSHASLIVCQNMYEYLIKTIERRANYRQGRGRAYLNAFRVGCATRLSQRWLSSRRSN
>NC_019753.1|WP_015201797.1|840878_843101_+|AAA-family-ATPase
MDLFEQHHLQQAENEAPLAARMRPRNLNKFIGQDHIIAPGRLLQRAITLDQLSSVIFYGPPGTGKTTLARVIANSTRAHFIAINAVLSGVKEIRASIDTATEKRKKHNQRTILFVDEVHRFNKSQQDALLPWVENGTVVLIGATTENPYFEVNKALVSRSRIFQLKQLNNDDLYRIVEQTLNDRERGYGNLNVKIEPNALDHLVNVANGDARSLLNALELAVETTPPDEAGIIYVTLAVAEESIQQRAVLYDKEGDAHFDTISAFIKSLRGSDPDAALYWLAKMVYAGEDPRFIFRRMLILTCEDVGLADPNAVVVVNSCAEAFDRVGMPEGRYHLAQATLYLANAPKSNSVMGFFDAIAAVEREKESEVPTHLKDGNRDKKGFGHGAGYLYPHAYRDHWVAQQYLPASLQGQVFYQPSQQGFEAKINTQVAQRREAQLAAVVAGDCVAPVEVLTYGVTDKATDRWLQRTLSQVGQQLGEIRDRIFTLTAPQRHHLILDLNAGSGLLTWEALRQVPEGGVYACIRTTADEEAIVEQATSLPELMRPIVLQSALTQLPEILAAQAADVKFDRIIGRNALLHESDKLTVIKLLASLLQDSGEIVLAETVAKHTQRLYCLLDISKLDADLCDRLITAEEAIYNNTSDPMVNWDADDLRIWFESAGLVVEVKEERLNSQLHISSGLIERWFGTNSDRPTYATYLGRLLSPQEVDTVKGLFNRYLLNQTVSWSSAIAFIQAKSNQ
>NC_019753.1|WP_015201799.1|844725_846207_-|glycerol-kinase-GlpK
MSKYILAFDQGTTSSRAIVFDPQGNLLSIAQKEFPQIFPQPSWVEHDPDEIWSSQIGVAHEVLARIGIHKSDIAAIGITNQRETTLVWNRQTGKPIYNAIVWQDRRTAKKCEQLKAQGYEATFQSKTGLVIDAYFSATKLQWLLDNVPNAREQAERGELAFGTIDSWLIWKLTEGELHITDVTNASRTLLFNIHTQQWDDELLSIFNIPHSLLPEVRSCSEVYGYTSSNILGSRIPIAGIAGDQQAATFGQAALERGMAKNTYGTGCFMLLNTGDEPIPSHHKLLTTIAWQINGHTDYALEGSVFIAGAVVQWLRDGLGIIKHSADVESLAGSVPDNGGVYFVPAFVGLGAPYWDSYARGTITGLTRGSTSAHIARAALESIAYQTADVLDAMRTDSHLDISELRVDGGASRNDLLMQFQADILGVPVVRPKITETTALGAAYLAGLAVGYWDSSEIVQQWQVEKRFEPTISAEHRATLRDSWRQAIELTQAW
>NC_019753.1|WP_015201800.1|846592_847660_+|NAD/NADP-octopine/nopaline-dehydrogenase
MLQTSYLVVGKGHIGLASALYLSAQGYTVYLFSRRHSIVAKTKTIHSIGAVSPGSYPVAACSNNLDELAALNGGQLPLNVLICCRGQDIEPYARILAKYINPQMNVLVLCASRFAGWVFCKVLTRLGIAEAQLPAVADVNNTPFVSRGNTEDQVRISTLTNKFFVAAQNRTMTNRIVVAYEAVFSNLCPAASVLEINLNKVNDIIHLPLLLVSLARWESGEDYNIYHKVGARTVGLIDHLDGDRMAVGEALGVLNLIDIKSHYQIAYGTKGPSLYEHMQQLGAYSSTTLCNPHHRYLVEDLPYGCFPLQVLARLAGVETPFLDSCITIGSKFLDIPLPWTAEFLELERQLLSQEL

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Crispr_ID: NC_019753_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_6

992622-993675

TypeI-D,TypeV

I-D,II-B

Consensus_repeat	Method
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	PILER-CR
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CRISPRCasFinder
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CRT

14 spacers

cas2,cas4,cas6,csc1gr5,csc2gr7,cas10d,cas3,WYL

The CRISPR arrays of NC_019753_6

>merge|NC_019753|6|992622-993675|PILER-CR,CRISPRCasFinder,CRT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACAATTTTTTCGTCAGTGGTGGGAATGGTCTATTTATTTGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACAAAGACCTAATTCCTTATTAACCGCCTTGCGAAGGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACTTTTCAATAGCTGACCCATCAGGATTAATAGTTTTGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACTTAAAGAACCATCAGGATTAGTAGTTTTTACAGGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACCAGACTATAACCATAGGAAGCTTGAAAATCAACAATTTGATTACAGCCGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACGGATATTTTGACTATTAGTAGGTGCCCAAAGATTGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACACGGGAATGGCAGCAGAAGCGGCGGCGAGCGAAGCGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACAGAAATCCACTAGGATTATATTTTTTAATAGTATAAGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACAATTCGTAGCGGTCTAAGTTCTGAATCAACCTAGGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACAACAAATCAACTGGTGTGGGTTAGGCTACTATTTGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACCCTTAATAGTCAAGGTGTAGAGTCTCTGGGGTTACGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACAGGATTCGTAACACCGATGATATTAAGTACGTTGGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACCTTGGCTACTATGGCGTGGGAACTTCAGTTGGCGAGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACGTTAGGGGTTTTTTCTCATGAATTATTCCTTTTTTGCGAAAATTACTAATAATCCCTTTTAGGGATTGAAAC

>NC_019753|6|4|992622-993675|PILER-CR
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AATTTTTTCGTCAGTGGTGGGAATGGTCTATTTATTT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AAAGACCTAATTCCTTATTAACCGCCTTGCGAAG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	TTTTCAATAGCTGACCCATCAGGATTAATAGTTTT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	TTAAAGAACCATCAGGATTAGTAGTTTTTACAG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CAGACTATAACCATAGGAAGCTTGAAAATCAACAATTTGATTACAGCC
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	GGATATTTTGACTATTAGTAGGTGCCCAAAGATT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	ACGGGAATGGCAGCAGAAGCGGCGGCGAGCGAAGC
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AGAAATCCACTAGGATTATATTTTTTAATAGTATAA
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AATTCGTAGCGGTCTAAGTTCTGAATCAACCTAG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AACAAATCAACTGGTGTGGGTTAGGCTACTATTT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CCTTAATAGTCAAGGTGTAGAGTCTCTGGGGTTAC
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AGGATTCGTAACACCGATGATATTAAGTACGTTG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CTTGGCTACTATGGCGTGGGAACTTCAGTTGGCGA
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	GTTAGGGGTTTTTTCTCATGAATTATTCCTTTTTT
GCGAAAATTACTAATAATCCCTTTTAGGGATTGAAAC

>NC_019753|6|5|992622-993675|CRISPRCasFinder
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AATTTTTTCGTCAGTGGTGGGAATGGTCTATTTATTT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AAAGACCTAATTCCTTATTAACCGCCTTGCGAAG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	TTTTCAATAGCTGACCCATCAGGATTAATAGTTTT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	TTAAAGAACCATCAGGATTAGTAGTTTTTACAG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CAGACTATAACCATAGGAAGCTTGAAAATCAACAATTTGATTACAGCC
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	GGATATTTTGACTATTAGTAGGTGCCCAAAGATT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	ACGGGAATGGCAGCAGAAGCGGCGGCGAGCGAAGC
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AGAAATCCACTAGGATTATATTTTTTAATAGTATAA
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AATTCGTAGCGGTCTAAGTTCTGAATCAACCTAG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AACAAATCAACTGGTGTGGGTTAGGCTACTATTT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CCTTAATAGTCAAGGTGTAGAGTCTCTGGGGTTAC
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AGGATTCGTAACACCGATGATATTAAGTACGTTG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CTTGGCTACTATGGCGTGGGAACTTCAGTTGGCGA
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	GTTAGGGGTTTTTTCTCATGAATTATTCCTTTTTT
GCGAAAATTACTAATAATCCCTTTTAGGGATTGAAAC

>NC_019753|6|3|992622-993675|CRT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AATTTTTTCGTCAGTGGTGGGAATGGTCTATTTATTT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AAAGACCTAATTCCTTATTAACCGCCTTGCGAAG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	TTTTCAATAGCTGACCCATCAGGATTAATAGTTTT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	TTAAAGAACCATCAGGATTAGTAGTTTTTACAG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CAGACTATAACCATAGGAAGCTTGAAAATCAACAATTTGATTACAGCC
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	GGATATTTTGACTATTAGTAGGTGCCCAAAGATT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	ACGGGAATGGCAGCAGAAGCGGCGGCGAGCGAAGC
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AGAAATCCACTAGGATTATATTTTTTAATAGTATAA
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AATTCGTAGCGGTCTAAGTTCTGAATCAACCTAG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AACAAATCAACTGGTGTGGGTTAGGCTACTATTT
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CCTTAATAGTCAAGGTGTAGAGTCTCTGGGGTTAC
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	AGGATTCGTAACACCGATGATATTAAGTACGTTG
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	CTTGGCTACTATGGCGTGGGAACTTCAGTTGGCGA
GCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	GTTAGGGGTTTTTTCTCATGAATTATTCCTTTTTT
GCGAAAATTACTAATAATCCCTTTTAGGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015201920.1\|989656_990478_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NC_019753.1\|WP_015201922.1\|992098_992368_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_019753.1\|WP_041225934.1\|1003520_1004096_+\|ribosome-maturation-factor-RimM	unknown	unknown	gnl\|CDD\|234650
NC_019753.1\|WP_015201923.1\|993887_994646_-\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|224331
NC_019753.1\|WP_015201921.1\|990474_991065_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|187768
NC_019753.1\|WP_015201931.1\|1002806_1003406_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NC_019753.1\|WP_015201915.1\|981822_982683_-\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_019753.1\|WP_015201924.1\|994826_996275_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NC_019753.1\|WP_015201929.1\|999758_1000682_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|234835
NC_019753.1\|WP_157462406.1\|1001058_1002741_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|226651
NC_019753.1\|WP_015201916.1\|983011_985021_+\|type-I-D-CRISPR-associated-helicase-Cas3'	cas3	cd09710_cas3_CAS-I-D	gnl\|CDD\|187841
NC_019753.1\|WP_041225933.1\|988976_989645_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	gnl\|CDD\|274458
NC_019753.1\|WP_015201913.1\|980602_981061_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341362
NC_019753.1\|WP_015201927.1\|997163_998651_-\|AmpG-family-muropeptide-MFS-transporter	unknown	unknown	gnl\|CDD\|341039
NC_019753.1\|WP_157462405.1\|996371_996830_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_019753.1\|WP_015201914.1\|981092_981758_+\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|224331
NC_019753.1\|WP_015201917.1\|985031_987962_+\|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	cas10d	cd09712_cas10d_CAS-I-D	gnl\|CDD\|274469
NC_019753.1\|WP_015201926.1\|996924_997113_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201928.1\|998738_999371_-\|repressor-LexA	unknown	unknown	gnl\|CDD\|224885
NC_019753.1\|WP_015201918.1\|987974_988973_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	gnl\|CDD\|375747

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015201920.1\|989656_990478_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.0162e-48
NC_019753.1\|WP_015201922.1\|992098_992368_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.14042e-31
NC_019753.1\|WP_041225934.1\|1003520_1004096_+\|ribosome-maturation-factor-RimM	gnl\|CDD\|234650	PRK00122, rimM, 16S rRNA-processing protein RimM; Provisional.	2.21817e-64
NC_019753.1\|WP_015201923.1\|993887_994646_-\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	3.24172e-21
NC_019753.1\|WP_015201921.1\|990474_991065_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|187768	cd09637, Cas4_I-A_I-B_I-C_I-D_II-B, CRISPR/Cas system-associated protein Cas4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster.	2.33157e-55
NC_019753.1\|WP_015201931.1\|1002806_1003406_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	9.27582e-11
NC_019753.1\|WP_015201915.1\|981822_982683_-\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	4.34272e-10
NC_019753.1\|WP_015201924.1\|994826_996275_+\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	1.28968e-05
NC_019753.1\|WP_015201929.1\|999758_1000682_-\|ornithine-carbamoyltransferase	gnl\|CDD\|234835	PRK00779, PRK00779, ornithine carbamoyltransferase; Provisional.	0
NC_019753.1\|WP_157462406.1\|1001058_1002741_+\|alpha/beta-hydrolase	gnl\|CDD\|226651	COG4188, COG4188, Predicted dienelactone hydrolase [General function prediction only].	2.0508e-81
NC_019753.1\|WP_015201916.1\|983011_985021_+\|type-I-D-CRISPR-associated-helicase-Cas3'	gnl\|CDD\|187841	cd09710, Cas3_I-D, CRISPR/Cas system-associated protein Cas3; Distinct diverged subfamily of Cas3 helicase domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Diverged DNA helicase Cas3'; signature gene for Type I and subtype I-D.	9.63917e-67
NC_019753.1\|WP_041225933.1\|988976_989645_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	gnl\|CDD\|274458	TIGR03159, cas_Csc1, CRISPR type I-D/CYANO-associated protein Csc1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. This family is designated Csc1 for CRISPR/Cas Subtype Cyano protein 1, as it is often the first gene upstream of the core cas genes, cas3-cas4-cas1-cas2.	2.00446e-64
NC_019753.1\|WP_015201913.1\|980602_981061_+\|CBS-domain-containing-protein	gnl\|CDD\|341362	cd04586, CBS_pair_BON_assoc, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection proteins. It is also found in some secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	1.12272e-58
NC_019753.1\|WP_015201927.1\|997163_998651_-\|AmpG-family-muropeptide-MFS-transporter	gnl\|CDD\|341039	cd17486, MFS_AmpG_like, AmpG and similar transporters of the Major Facilitator Superfamily. AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.66311e-73
NC_019753.1\|WP_157462405.1\|996371_996830_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.21256e-17
NC_019753.1\|WP_015201914.1\|981092_981758_+\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	9.38525e-22
NC_019753.1\|WP_015201917.1\|985031_987962_+\|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	gnl\|CDD\|274469	TIGR03174, cas_Csc3, CRISPR type I-D/CYANO-associated protein Csc3/Cas10d. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. This family is designated Csc3 for CRISPR/Cas Subtype Cyano protein 3, as it is often the third gene upstream of the core cas genes, cas3-cas4-cas1-cas2.	3.23782e-93
NC_019753.1\|WP_015201928.1\|998738_999371_-\|repressor-LexA	gnl\|CDD\|224885	COG1974, LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms].	1.41389e-69
NC_019753.1\|WP_015201918.1\|987974_988973_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	gnl\|CDD\|375747	pfam18320, Csc2, Csc2 Crispr. The Csc2 Crispr family of proteins forms a core RNA recognition motif-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	8.00678e-141

>NC_019753.1|WP_015201922.1|992098_992368_+|CRISPR-associated-endonuclease-Cas2
MHVVVAYDISEDKRRTKIHSILKSYGQWMQFSLFECNLTDTQYAKLRSRLSKMIKADDSILFYFLCACCQTKVERIGGEQVRDETIFFA
>NC_019753.1|WP_015201921.1|990474_991065_+|CRISPR-associated-protein-Cas4
MNSVDYIQISALNQYSYCPHRCWRMFCAGEFVDNNYTIEGTSLHDRVHTLGEGHRDETWQVRAIYLKSEQYHLIGKSDLIEEMDGCCYPVEYKRGHKGEFDNDEMQVVAQALCLEEMTKQPVTKGYIYYAQSHQRQLVEITDELRKQAIATIQAVSTLLETGKMPSPNYSKRCQGCSLYTQCLPQAATKVNRYQEN
>NC_019753.1|WP_015201920.1|989656_990478_+|CRISPR-associated-endoribonuclease-Cas6
MPHSLVLKLLPTSPIQPGYLTGKHLHALFLTLVSSVDRELGSRLHEQKADKAFSLSPLQISTRPSRNHNLQWEHNKPIPAGTPCWWRISLLDDSLFGHLTQLWLNLNPSHPWHLGSADLQITSILGTPQSTQPWVNFASYPQLYEQASEEQRLIDFAFCTPTAFRQTQFDTALPTKDLVFNSLLRRWNQYSNIEFAPTLTESIFPSFFDIHTEIITDSRSKFIGCVGMLSFRILGEVDSQIIKRINTLADFALYSGVGRKTPMGMGMLRRLNK
>NC_019753.1|WP_041225933.1|988976_989645_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1
MMHIYQLCLTLQDPLYFATRELGRLYATENYLHNYALTYALGLAKSCYHDAEHIPHYQEDLEPLNKRGIYVTPARPVNFAYVTHTYKWADLRYQVKMEQSSVNLPTFGRIRELAPESTFEAYLLASEPVKLPQWIRLGKWMSKVQVKMKELPKHKQSEGIFTVEFPLNPLDTMFTNQLLSYDVVNMPPVSLIRNVQMRGRYYQFDELKGLKIPVSMEYRFQA
>NC_019753.1|WP_015201918.1|987974_988973_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2
MFDKYQSHFQVSIPKIPGAKYAHFIVLRETDSYAVFKTDGELNVARVRAGLNKTDVITRLVLFKRKQTTPERLTGRELLRRYDIYEQIKTQYERVTTKKEKQIEGCTYNGEPCGGCPDCVIYGYAVGESGSEKSKVFIDSAYAIPPYEDSHGTFTLNAPYEDGTMTSGTSTTNRFSEQDHVLPEIPFPSVVTLRDPSPNTFLYVLNNIYRTKRYGAQTTRTGQLRNHLVGIIFADGEIFSNLRLTQKIYDLLDGKNPPYSVEDMKEKTEQSIEELIKQDGVLYELIKGDSLLSVENEAQSILSDETQFKNWLGSITQETLAYAERAKVLKKK
>NC_019753.1|WP_015201917.1|985031_987962_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3
MEDISWLMPGNYNVPNPKKSKEPPLVRLALDTLNDEQDSVLRNWIEIVFPYILDYFSLRDAKGTSYQSAKELTEDLDIPVEKREKIINKLVNLKDQSLAVHLLNAALGGWTLVKLGGLDELQQRYYLAAMTMHDLNKIVLPRLGSTRMDGKEWEKYKTAFLEWGEALHLWDFIARQYWQDVAFLAQNAEDARGANLTLANFPDLQLPPNQLMDLVDFVRFGDLVASIAHHPDDLEQESMRGLLRRTVGGKYIIRSHRTNENRGLLTQAIHNAVLEQAEKVNWKAFLFFPDGVTYFAPKDSNDPDLSKIPKAVRNNTLEIVKKGVGSLVTREGKGIKYYPDLVEVANVSLATETIIRRTFGIISEKKTPVTGARRDKIRQKFAHLSDLDWEYPANLQTDRLAEGLNGITGLIEDYYGLDKEAIAQHILNSLKLTNYFEDWKRIPSDGGVPHSWYYLAGHYMRQHPTLNESELEQVMLTTVPEILQQLGKPDRPPPFAFLDQYIAQVLTVTGSTEKHNFKAELDRYHLNKAKRKREAICSICNSAFDIREEFSNYSNKRVTSGSKESKRGICTICQVEKLLRRYGMDADLVPENETIYLHLYPAYYFTPETALMMKLAYDNFAQSSFVELDKDFFAQEYNPNYVPRLDIFRIGLDPNENLKRRTKKGYATGKMHGYYLLGIPYLGEKPTDTEAWYMAAIKALLAPITFGVKLVASRNPVPVYNSGADFKETIIIDGVHTYWLHGMKETIFRLDELEKAIPAVFSIYSLTAQAYKDSRNFPVWNQLNTVCQSLDTSPLYVFHYADRIQANSKAEDLPMWLAEKLIHYYEILISYYKGDDPMQMIRDIVDKYACFYRASGFAAYARLRPLNVAMKVVLDSLPHTSKDDLKLMIEGHLIALVDGVLDKQTDGYIPEEVKKDIAQRQEAIETFSGSFLEQVFYDYCKGERSLLRQHINLIRKGSEAYYVKTYSKKKNQQETK
>NC_019753.1|WP_015201916.1|983011_985021_+|type-I-D-CRISPR-associated-helicase-Cas3'
MIKLLSTWSELLGEVDPVAKIQLVTHQKAVWDALRDPKVQIIFDTALTGDGKTLAGLLPAFYESRSLGKGLFAYPTNELIRDQAKQVNEWNQRLNIAIKPHQLNSQSLAELVSEEGFDKLETLRNLASDRDINVILTNPDIFTLIHRFFYNRYKGNIAKLSEIWFNYFRYIVFDEFHIFGAPQVTNVLDAIAFSRAHLGDQYPAKFLFLSATPDKLIQQALDKAGIIAKIIHGKYQHGLKESENHRCILREVELELVASQQSSGGVESWIKENLEKINHFFINYPNSKGLIIVNSVFAAKRIIRQLKDNPACNFTVGENTGLTSLDIRKDSENKQLIIATSTVDVGVDFKINFLIYESLDAGTFIQRLGRLGRHEGFPIYKAIALVPDWVKEKFSELYPDGVEIDRESFFETVRDEIYQKPQMFEKYLIRWGKVLSTLRYARLSSPKDQYQTLLERYAVEASNILGETPKWCRLNELKEHQIIIKDLETFRGTGELDIWVYELETNAISSISLIRLLSGTDFKLLSESEAEKLSQKFVHPFHKNSLRLYAIINNYLDSYQNVELEFTYYLDRLNINQAQQRIGFRIQARHSEIRKINEQLEGLELTTCVADPINYDIPKLKRIYRLPAFFELYLVKDFSGGTYPVAFGQDALLLDSLLFWQKTNTAMIC
>NC_019753.1|WP_015201915.1|981822_982683_-|WYL-domain-containing-protein
MSRKKEALTLSVPPGTKEKLEAIARRLNIFWGKSPSPSGLVVAIAQQELRVGSEAFNLNEQQIKALRQATKLLIDAGQIQEAEIINTLLLNQGDLEAPLRQVLLQQQTRSIQAWRDRIDELIANRQPFRLLYHNSQRQDLEYTVRYAEVMFYEKRFYLQTWCEETADALATDPDLPEVAHNRCLRFDRIRDIQPTSGIWRGEFDSIKVYLHLKGWLANAYEPKEADIENVVLGDIRQVVRRVVNPFWLIWEVFKYRAECEIVAPDSVRDRIKQELRTLCQLYDLEV
>NC_019753.1|WP_015201914.1|981092_981758_+|HEAT-repeat-domain-containing-protein
MSNTPESVKELLSSGDLGDRLRGVNQLLEIEPAAAFELVQVAINDSNARVRYTAVSKLDTLGDQDLQAALTMLRDRLLNDSEPDVQAAAADSLGALKLTEAFEDLQNLYHSTSEWLIQFSIIAALGELGDPRAFDLLTEALNSDIELVKTAAIGSFGELGDARAVPLLVPYATNPDWQIRYRVVQALGRLGGTDARLTLETLANDSVEQVAQEAKASLNAQ
>NC_019753.1|WP_015201913.1|980602_981061_+|CBS-domain-containing-protein
MSKTVADVMSRDVITVQPQTPLNQAIQILAERRITGLPVVDDADKLVGVISETDLMWQETGVTPPAYIMFLDSVIYLQNPTTYERDLHKALGQTVGEVMTTEAIVIKPEKPLQEAAKLMHEKHIRRLPVVDDTGKVLGILTRGDIIRTMATE
>NC_019753.1|WP_015201923.1|993887_994646_-|HEAT-repeat-domain-containing-protein
MYNDEDLTLLDPDAELESPLDQLEPIDAETEAPQIDPEAMLALLDSAATPQRMLAARAFCELQDNRAIPRLISLLTDACPLVRVSAAYALGRNPSTTAVEQLIAQLNRDWNGYVRKGVVWALGNCRDRRSLTPLTHALKTDISAVRLWAASSLAQMADLGYEAVVASIPPLIEALVQDPVAGVRSNCAWSIGQLCRELPSNVVYATAVDALIQVLEEDQDLGVREDAKAALLKLGDARGLQAIEALEIEEIS
>NC_019753.1|WP_015201924.1|994826_996275_+|hypothetical-protein
MTEYLESYRRMARAIRFVPPLARNQEYHRQIHDLVPPAVVVNSVSKNILPDTTETPALGPAPDPSEHIAALVRDAVSKPTVMPVIYAIPENIGDRISRMAPPKPLNQVVFAPKLPEPDPNWIAAQKVAQSPPALEENTQVEDSPASAITSSSVVAPPPEVQQEMPAIETPESTVLETDNQVEETPPTPKPALEAPPAEETPVQAELPSSSETEAIAPGVATETPSLEEIPSQEPALENSTSNENVEQTPYLAAETFTTEAPPAEETEIHPTEPEASVPETAPLEQNATEENSTEVTPAISLESTASAPVAPETSVLEEIPSQALEVEHSTEAEVLPQIETPAPVESLQVSSPSDGTETNLESLSSSSLEVTSPESSLQPTIPDSKEETQVKCPACDSTELRKNGHRKDKQRYICKDCGKQFVEPDTLAAKNHPSSNKSATKTAEAKENKSVTGVSDRASKSSSNQGKTNKKSKGFGTRKNKK
>NC_019753.1|WP_157462405.1|996371_996830_-|GNAT-family-N-acetyltransferase
MQLTYQELFLEQQDFSHLAVTVERYFSQETPLWLVEFLGSEEQETPSISNEQGGLIRKVSAVPAIACLWLGNAVDQVQGDRFSHIFLLYVNPNHRRRGIGSALMRHAENWAKSKGDRQIGLQVFEINTPAVNLYHKLGYQTQSLWMVKPLSK
>NC_019753.1|WP_015201926.1|996924_997113_-|hypothetical-protein
MAFLRQYIAPFLILLVFLVALVAVSIRSFIPQDMAAPAPIESVNSDQVSVIGDKLITFVDYC
>NC_019753.1|WP_015201927.1|997163_998651_-|AmpG-family-muropeptide-MFS-transporter
MKATQSLLQAFQSRKMAALSLLGFSSGLPLFLTSRTLQVWMTEEKVDLGVIGLFAIVSLPYSLKFAWSPLLDRFAPPFLGRRRGWLVVTQVGLLLAIAAMALQKPAQDVQVLQLLAINALIITFLSATQDIAGDAYRTDVLKPNELEAGASIWVLGYRVALLATSFLALILADYMPWNVVYLLMAAFMAVGLITSFWAPPAAGEDLQNRSPLSLKDIIFLIIIVALVVGLLAGVFTSFIPLNVFYWVVASLIVVWLITSFLLPKRNLENVLSDRPPQSLQDAVVMPFQEFFQRFGLPKGSLILVFILLYKLGDALVGNMANPFLIAINFTKTQIGAIQGGMGFLATTVGVLAGGAILTKLGINRCLWIFGILQLVSNFGYYALAVTGKNDSLLVVAINIENFCAGLVTVVTVAFLMSLCNHRFTTTQFALFSSLVAISRDILSAPAGQLAKATGWPSFFLITVVLAIPGLLLLPVVAPWNGQPMAIPNSGINDQN
>NC_019753.1|WP_015201928.1|998738_999371_-|repressor-LexA
MEPLTDAQQKLYDWLVDYISQHQHAPSIRQMMLAMNLKSPAPIQSRLEHLRIKGYINWTEGKARTLRIIRGANGVPVLGTIAAGGLVEPFTDVVDHIDFSQVFRQPDYFALRVVGDSMIDDQIAEGDMVIMRPVPEPERVKNGTIVAARVEAHGTTLKRYHRHGETITLKPSNPKYDPIKVMANQVEVQGILVGVWRGYDSVLKSTPKRQ
>NC_019753.1|WP_015201929.1|999758_1000682_-|ornithine-carbamoyltransferase
MEVLKGRDLLSLADLTTDEIHELLDLAAKLKSGAVNLRCNKVLGLLFYKASTRTRVSFTVAMYQLGGQVIDLNPNVTQVSRGEPLADTARVLDRYLDILAIRTFEPEDLQTFANYAQIPIINALTDLEHPCQILADLLTVQESFGSLENLTLTYLGDGNNVAHSLLLGCALVGMNVRIATPDKFQPNQQIVQQAEEIAAIKGTEVIITQDAQAAVKGASVIYTDVWASMGQEDQAGDRIPIFQPYQVNEQLLSSANSDAIVLHCLPAHRGEEITDGVMEGKQSRIWDQAENRMHAQKALLVSLLGAD
>NC_019753.1|WP_157462406.1|1001058_1002741_+|alpha/beta-hydrolase
MPLKAKLGIVLLNLGCLILPGVASKPVLSAEKLYVTYGPLDFSLPVSALEAYAREGKIEPEFAFYTRFFDQKQLEQLRRVLVRRAKISPVRISQILYSPTGEILLGRIGEVVQTKANQPGFYAIRAAMIQAAASPEGLTPLNVLKKFPTYGIRINTERGFQVIDELNNLIGESQNAIAAIEQVATTEASAQSLVDFSGLPDIRKPGSFTWKKQTINLNDIRRRRIFPVDIYLPQGPNQRPLPVVVISHGLGDDRETFGYLAQHLASYGFAVAVPEHSGSNTKRIESVLSGFSRSLVVPSELVDRPIDIKYLLDQLDRLFPKQLNLQQVGVAGQSFGGYTSLALAGAKLNFEQLQKDCANSQDSLNVSLILQCSGLVLPPNNYQLQDERVKAVSAINPVSSSLFGESQISQIKIPTMIVSGSADTVTPAFSEQIKPFTWLTTPEKFLVLLKGGTHFSVLKESEGVVPLPAQALGPDPKIAYEYMKALNLAFFKTYIAGELPYKAYLNAGYAQLISQYQIPLNLVQNITPQQLTEGDAQPTPASSPEASPSPSPSPSLSPTP
>NC_019753.1|WP_015201931.1|1002806_1003406_+|tetratricopeptide-repeat-protein
MRSQTKFLSFLIFSLVVTASYTLPAAANSSGDTNFIGGSNNAIQNQPLQATQLFKQGVEQYRSHQYQDALNTYQQVLKIYREVGDEAGESRTLHNLGIISFYLKEPAQAIELLQQSLNIREKINDKVGTARSLDNIRKIKMLQTQTMVSPSSEISLIFDEDDKPALRSLDSSTGDKNIIPESNDPVTPPSDEKEVLFIW
>NC_019753.1|WP_041225934.1|1003520_1004096_+|ribosome-maturation-factor-RimM
MANSEWLEIGTIVAPQGLNGEMRVYPTSDFPERFEEPGTRWLLKPGETEPQPIELLGGYYLAGKNLYVVELAGIEDRSQVEELRGYQLMVPESDRPTLAEDEYHIIDLVGAEVFNQLTGENLGVVVSVISAGNDLLEVKRHQTSASTSQSDSKQKSAKTVLIPFVKEIVPVVDIIQKRIEINPPPGLLDLA

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Crispr_ID: NC_019753_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_7

1168466-1168834

Orphan

Consensus_repeat	Method
GTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC	CRISPRCasFinder
GTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC	CRT
GTCAGATACTATCT---------TTTCCCCGCAAGGGGACGGAAAC	PILER-CR

4 spacers

The CRISPR arrays of NC_019753_7

>merge|NC_019753|7|1168466-1168834|CRISPRCasFinder,CRT,PILER-CR
ATTTCCGTCCCCTTGCGGGGAAAAGGTAGTATCTGACTCTTAAAGCCCAAACTCAAATATGGTGACGAGTATCCTCTGGATATTAAGAAGTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGACGTACTTATCATGGCTCATATCACTTTAATCGTTGCTAATGCGTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGACCAGAAGAAATACTCTGCCAAACTCGATGGTCTATGGTTGTTACAAGTGTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGACACCTTTAACTATTCCAGTCTTACTCTTCATCCTTCTGAAGTTAGGTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC

>NC_019753|7|6|1168466-1168834|CRISPRCasFinder
ATTTCCGTCCCCTTGCGGGGAAAAGGTAGTATCTGAC	TCTTAAAGCCCAAACTCAAATATGGTGACGAGTATCCTCTGGATATTAAGAA
GTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC	GTACTTATCATGGCTCATATCACTTTAATCGTTGCTAATGC
GTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC	CAGAAGAAATACTCTGCCAAACTCGATGGTCTATGGTTGTTACAAGT
GTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC	ACCTTTAACTATTCCAGTCTTACTCTTCATCCTTCTGAAGTTAG
GTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC

>NC_019753|7|4|1168466-1168834|CRT
ATTTCCGTCCCCTTGCGGGGAAAAGGTAGTATCTGAC	TCTTAAAGCCCAAACTCAAATATGGTGACGAGTATCCTCTGGATATTAAGAA
GTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC	GTACTTATCATGGCTCATATCACTTTAATCGTTGCTAATGC
GTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC	CAGAAGAAATACTCTGCCAAACTCGATGGTCTATGGTTGTTACAAGT
GTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC	ACCTTTAACTATTCCAGTCTTACTCTTCATCCTTCTGAAGTTAG
GTTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC

>NC_019753|7|5|1168467-1168834|PILER-CR
TTTCCGTCCCCTTGCGGGGAAAAGGTAGTATCTGACT	CTTAAAGCCCAAACTCAAATATGGTGACGAGTATCCTCTGGATATTAAGAAG
TTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGACG	TACTTATCATGGCTCATATCACTTTAATCGTTGCTAATGCG
TTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGACC	AGAAGAAATACTCTGCCAAACTCGATGGTCTATGGTTGTTACAAGTG
TTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGACA	CCTTTAACTATTCCAGTCTTACTCTTCATCCTTCTGAAGTTAGG
TTTCCGTCCCCTTGCGGGGAAAAGATAGTATCTGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015202077.1\|1157838_1158729_+\|aldose-1-epimerase	unknown	unknown	gnl\|CDD\|185702
NC_019753.1\|WP_015202089.1\|1171442_1171844_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202076.1\|1156466_1156769_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202078.1\|1159032_1160106_+\|fructose-bisphosphate-aldolase-class-II	unknown	unknown	gnl\|CDD\|181691
NC_019753.1\|WP_015202081.1\|1162826_1165487_-\|DNA-gyrase-subunit-A	unknown	unknown	gnl\|CDD\|235502
NC_019753.1\|WP_015202093.1\|1175770_1176373_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238279
NC_019753.1\|WP_015202082.1\|1165822_1166134_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|240845
NC_019753.1\|WP_041226374.1\|1160293_1160767_-\|TspO/MBR-family-protein	unknown	unknown	gnl\|CDD\|226007
NC_019753.1\|WP_015202087.1\|1170369_1170465_+\|cytochrome-b6-f-complex-subunit-6	unknown	unknown	gnl\|CDD\|282910
NC_019753.1\|WP_015202090.1\|1172600_1173413_+\|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|143596
NC_019753.1\|WP_015202088.1\|1170526_1171309_-\|MlaE-family-lipid-ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|215575
NC_019753.1\|WP_015202086.1\|1169175_1170276_-\|3-dehydroquinate-synthase	unknown	unknown	gnl\|CDD\|234565
NC_019753.1\|WP_015202085.1\|1168070_1168385_+\|DUF4926-domain-containing-protein	unknown	unknown	gnl\|CDD\|379816
NC_019753.1\|WP_015202094.1\|1176496_1177126_+\|imidazole-glycerol-phosphate-synthase-subunit-HisH	unknown	unknown	gnl\|CDD\|237288
NC_019753.1\|WP_015202091.1\|1173729_1174137_-\|DUF1311-domain-containing-protein	unknown	unknown	gnl\|CDD\|226278
NC_019753.1\|WP_015202084.1\|1167081_1168059_+\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NC_019753.1\|WP_015202092.1\|1174372_1175770_-\|DUF3370-domain-containing-protein	unknown	unknown	gnl\|CDD\|314680
NC_019753.1\|WP_015202083.1\|1166373_1166925_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_041226379.1\|1177202_1177769_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|223813
NC_019753.1\|WP_015202080.1\|1161441_1162374_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372383

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015202077.1\|1157838_1158729_+\|aldose-1-epimerase	gnl\|CDD\|185702	cd09025, Aldose_epim_Slr1438, Aldose 1-epimerase, similar to Synechocystis Slr1438. Proteins similar to Synechocystis Slr1438 are uncharacterized members of aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	8.1502e-141
NC_019753.1\|WP_015202078.1\|1159032_1160106_+\|fructose-bisphosphate-aldolase-class-II	gnl\|CDD\|181691	PRK09196, PRK09196, fructose-bisphosphate aldolase class II.	0
NC_019753.1\|WP_015202093.1\|1175770_1176373_-\|hypothetical-protein	gnl\|CDD\|238279	cd00501, Peptidase_C15, Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from proteolysis by other proteases until the pGlu is removed by a PGP. PGPs are cysteine proteases with a Cys-His-Glu/Asp catalytic triad. Type I PGPs are found in a wide variety of prokaryotes and eukaryotes. It is not clear whether the functional form is a monomer, a homodimer, or a homotetramer.	4.78926e-15
NC_019753.1\|WP_015202082.1\|1165822_1166134_+\|RNA-binding-protein	gnl\|CDD\|240845	cd12399, RRM_HP0827_like, RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins. This subfamily corresponds to the RRM of H. pylori HP0827, a putative ssDNA-binding protein 12rnp2 precursor, containing one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). The ssDNA binding may be important in activation of HP0827. .	9.53027e-34
NC_019753.1\|WP_041226374.1\|1160293_1160767_-\|TspO/MBR-family-protein	gnl\|CDD\|226007	COG3476, COG3476, Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms].	3.32726e-48
NC_019753.1\|WP_015202087.1\|1170369_1170465_+\|cytochrome-b6-f-complex-subunit-6	gnl\|CDD\|282910	pfam05115, PetL, Cytochrome B6-F complex subunit VI (PetL). This family consists of several Cytochrome B6-F complex subunit VI (PetL) proteins found in several plant species. PetL is one of the small subunits which make up The cytochrome b(6)f complex. PetL is strictly required neither for the accumulation nor for the function of cytochrome b6f; in its absence, however, the complex becomes unstable in vivo in aging cells and labile in vitro. It has been suggested that the N-terminus of the protein is likely to lie in the thylakoid lumen.	0.00504092
NC_019753.1\|WP_015202090.1\|1172600_1173413_+\|carbon-nitrogen-hydrolase-family-protein	gnl\|CDD\|143596	cd07572, nit, Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases). This subgroup includes mammalian Nit1 and Nit2, the Nit1-like domain of the invertebrate NitFhit, and various uncharacterized bacterial and archaeal Nit-like proteins. Nit1 and Nit2 are candidate tumor suppressor proteins. In NitFhit, the Nit1-like domain is encoded as a fusion protein with the non-homologous tumor suppressor, fragile histidine triad (Fhit). Mammalian Nit1 and Fhit may affect distinct signal pathways, and both may participate in DNA damage-induced apoptosis. Nit1 is a negative regulator in T cells. Overexpression of Nit2 in HeLa cells leads to a suppression of cell growth through cell cycle arrest in G2. These Nit proteins and the Nit1-like domain of NitFhit belong to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 10.	9.76892e-141
NC_019753.1\|WP_015202088.1\|1170526_1171309_-\|MlaE-family-lipid-ABC-transporter-permease-subunit	gnl\|CDD\|215575	PLN03100, PLN03100, Permease subunit of ER-derived-lipid transporter; Provisional.	8.91877e-84
NC_019753.1\|WP_015202086.1\|1169175_1170276_-\|3-dehydroquinate-synthase	gnl\|CDD\|234565	PRK00002, aroB, 3-dehydroquinate synthase; Reviewed.	0
NC_019753.1\|WP_015202085.1\|1168070_1168385_+\|DUF4926-domain-containing-protein	gnl\|CDD\|379816	pfam16277, DUF4926, Domain of unknown function (DUF4926). This family consists of uncharacterized proteins around 70 residues in length and is mainly found in various Caulobacter, Microcystis and Cyanothece species. The function of this family is unknown.	6.49314e-23
NC_019753.1\|WP_015202094.1\|1176496_1177126_+\|imidazole-glycerol-phosphate-synthase-subunit-HisH	gnl\|CDD\|237288	PRK13141, hisH, imidazole glycerol phosphate synthase subunit HisH; Provisional.	1.34499e-127
NC_019753.1\|WP_015202091.1\|1173729_1174137_-\|DUF1311-domain-containing-protein	gnl\|CDD\|226278	COG3755, COG3755, Uncharacterized protein conserved in bacteria [Function unknown].	1.28229e-20
NC_019753.1\|WP_015202084.1\|1167081_1168059_+\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	7.61452e-161
NC_019753.1\|WP_015202092.1\|1174372_1175770_-\|DUF3370-domain-containing-protein	gnl\|CDD\|314680	pfam11850, DUF3370, Protein of unknown function (DUF3370). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 452 to 532 amino acids in length.	0
NC_019753.1\|WP_015202081.1\|1162826_1165487_-\|DNA-gyrase-subunit-A	gnl\|CDD\|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0
NC_019753.1\|WP_041226379.1\|1177202_1177769_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|223813	COG0742, COG0742, N6-adenine-specific methylase [DNA replication, recombination, and repair].	7.42583e-66
NC_019753.1\|WP_015202080.1\|1161441_1162374_+\|hypothetical-protein	gnl\|CDD\|372383	pfam12920, TcdA_TcdB_pore, TcdA/TcdB pore forming domain. This family represents the most conserved region within the C. difficile Toxin A and Toxin B pore forming region.	0.00144013

>NC_019753.1|WP_015202085.1|1168070_1168385_+|DUF4926-domain-containing-protein
MIKPELLDIVEILVNLPEYQQFVGAQGTIVECYDSENFEIEFSNEDGETTALCALSSQQFIVIWKAAKKQWLTPADKIAAIFNNLSEAKREEVLDFARFLYQKA
>NC_019753.1|WP_015202084.1|1167081_1168059_+|GTPase-Era
MMEHDQEISAIDNLDISAFRIPVAPEGYKSGFVGIIGRPNVGKSTLMNQMVGQKIAITSPIAQTTRNRLRGILTTPQAQFIFVDTPGIHKPQHKLGEVLVRNAKIAIDSVDVLVFVVDGAVDAGGGDRFIADLLNNTKTPVILGLNKIDQEPVKNQQREYIDQTYTELAKPHNWQIAKFSALTGEGIETLEQVLIDHLEPGPYYYPPDLVTDQPERFIMGELIREQILLLTREEVPHSVAVTIDVVEEDVKITRVLATIYVERDSQKGILIGKGGAMLKAIGSAAREQMQKLIAGKVYLELFVKVQPKWRQSRLHLAELGYRVEE
>NC_019753.1|WP_015202083.1|1166373_1166925_+|hypothetical-protein
MTPDAIRIVSQLRQDFYSLFATAIGVPVRISGKSYISNSAIASWVDDQQRLNYLNIYPYLAPDKFIPERPFILRIAINKSAGRFTRAKQGEICKGLNQDWDFELTLLPEELLDFLPWIVGLVNSHNRGGQPFVEEPPHPMSLQVANVGLWKNAWTQKANFVATHYKSVAPDGFISDYSLERIN
>NC_019753.1|WP_015202082.1|1165822_1166134_+|RNA-binding-protein
MSVYVGNLSFDVTQDDLSQAFAEYGTVKSVQLPTDRETGRMRGFGFVEMSSDAEETAAIDALDGAEWMGRDLKVNKAKPREDRRPSGGGGGGWDNNRRSSSRY
>NC_019753.1|WP_015202081.1|1162826_1165487_-|DNA-gyrase-subunit-A
MTTSQERIVPTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMHELGLSPDRPFRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRSPLINGHGNFGSVDNDPAAAMRYTECRLQALTADAMLRDIEAETVDFGDNFDGSQQEPLVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELIDALVTLIHNPEITDVELMQYVPGPDFPTGAQILGTAAIKEAYTTGRGSITMRGVATIETVENRGRPDREAIIITELPYQTNKAALIEKIAEMVNEKRLEGIADIRDESDRDGMRIVIELKRDCYPRVVLNNLYKQTPLQANFGCNMLAIVNGEPQLLTLKKFLEVFLDFRIEAITRRTQYELRKAEDRDHLLQGLLIALLNLDVLIELIRRAADTATARQEMMETYALSEQQADAILQMQLRRLTALEAEKIRMEHDELQAQIADLKDILARRSRILEIIETEVKDIRATHATPRRTVIEHGLGGLDDTDLIANEKALILLTEQGYIKRMPVNTFEAQSRATRGKAGAKMKEDDGVEHFLTCCDHDSILFFSDRGVVYCLRAYQIPGASRTSRGVPIVQLLPIPRNEKITSIVPVSEFTSEEYLVMLTQGGFIKKTALSAFGNIRANGLIAISLEEGDQLRWVRRARAEESIIIASRQGMAIHFRTSHEQLRPLGRATRGVRAMNLRKGDELISMDIIPSAVLASPEFEEVASETEETEDLSVIEIADETEDLSVVEIADETEDLELQEGLEVQEDSAVKSTGLWVLVVTMGGYGKRVPVSQFRLQNRAGKGLIATKFKTRKGKDQLISLRVVNAEDELMMITSRGIIIRQSVSAIPSQSREATGVRVQRLDEDDAIAAVALVPPSNGEEEEAE
>NC_019753.1|WP_015202080.1|1161441_1162374_+|hypothetical-protein
MKYSRFNSRRNFIWMVGISSLGAALGGLSRKSLAQRPPIVNPISPNPRSFRLAPNTQVLLRDIKLANPNDLTSLSKSRRVAPEVLDSAFDKLNEAFSFNPSSGQLTRNPAVRLSSDEEEVVQQILAGYQGQVQAGEIKLRRGTNQKFIPLTAEPEESRQGSVRQIIRPNTEILQPNTEILRPNFKSTEKLAKPEEILGLSTFSPFDTNSKPVGSDSYLLAQGCGWQWWRKFYWWGVRLSFNRTAVNWIAGAAGGAASVLAAMGITGIAAVIVGAIGAGLKALSNNNGIRIYITWAGVSWALPKPTSSGGC
>NC_019753.1|WP_041226374.1|1160293_1160767_-|TspO/MBR-family-protein
MIKPWMVIGGVTLLVAMGSNIVTPDDVRWFKRLQRPRWLTFEPAIPIIWTIVFICGAWSAYIVWTRDPGSTKTWLLMAFYLLVEIAIVAYNPVMLRLRSLKAGTIVGGIGSILGLILLLVVFPISGWASLLLLPYVIWSPIGTYTTWEMMKINPNDA
>NC_019753.1|WP_015202078.1|1159032_1160106_+|fructose-bisphosphate-aldolase-class-II
MALVPMRLLLDHAAENGYGIPAYNVNNMEQIQAIMKAAHETDSPVILQASRGARKYAGESFLRHLILAAVETYPDIPIAMHQDHGNSPATCYSAMSHGFTSVMMDGSLEADAKTPSSFEYNVDVTRKVVEVAHAIGVSVEGELGCLGSLETGQGEAEDGHGFEGTLSHDQLLTDPDEAVQFVEQTGVDALAVAIGTSHGAYKFTRKPTGEILAISRIEEIHRRLPNTHLVMHGSSSVPEDLLALINQYGGKIPETYGVPLEEIQKGIKSGVRKVNIDTDNRLAITAAVREALAAKPEEFDPRHFLNPSIKYMQKVCAERYQAFSAAGNASKIKPISLDDFAAKYAKGELTAKKAVTV
>NC_019753.1|WP_015202077.1|1157838_1158729_+|aldose-1-epimerase
MFAIAQKQQQYKTYILSDDKSQSQLEVVPERGGIITSWRIQGQEILYLDAERFTKPDLSVRGGIPILFPICGNLPENTYTFQNQPYTLKQHGFARDLPWEVTEQVTQDRLSLTIVLNSNDQTRAVYPFDFQLAFTYELIGNTLKIHQRYTNHGATTAGLSLEQMPFSTGLHPYFWTPHKTQLQFEIPSSEYYDQIHHTTHPFSGEFNFTQDEIDVAFKQLSSNSATITDNGRKLKLTLSYDDSYSTLVFWTVKGKDYYCIEPWTAARNALNTGESLLQLEPGASLETHVSLTVNFF
>NC_019753.1|WP_015202076.1|1156466_1156769_-|hypothetical-protein
MLHRKIYQLCCDGREVCIFLRDQQRWIERARILDIEGDLVTIRYEIDEEDEMCSWEEMVRLESIGAVSQKLASVPKGNAEPLVSDDCPEAEQIRPRFPEE
>NC_019753.1|WP_015202086.1|1169175_1170276_-|3-dehydroquinate-synthase
MQSVIRVELPEQSYDIAIASGSLDQLGEQCSGLSLGKKVLVVSNPVVFKHYGGIAIASLKSAGFDVYTCILPAGERYKTLNSIQKIYDVALEHRLERSSTMVALGGGVIGDMTGFAAATWLRGINFVQVPTTLLAMVDASVGGKTGVNHPQGKNLIGAFYQPRLVLIDPEILKTLPVREFRAGMAEVIKYGVIWDAGLFSQMEESKRLDQMRYLNEGLLTEILNKSCQAKADVVSKDEKEAGLRAILNYGHTIGHAVESLTGYRIVNHGEAVGIGMVAAGEIAVHLQLWDQESTQRQDALIKKAGLPTRLPAGLDLDAIADVLQTDKKVKAGKVRFILPTQIGVVTITDEVPADVIRQVLHQMQAA
>NC_019753.1|WP_015202087.1|1170369_1170465_+|cytochrome-b6-f-complex-subunit-6
MSGVIAYFLILGTAFVTAVGLYFGLRAVKLI
>NC_019753.1|WP_015202088.1|1170526_1171309_-|MlaE-family-lipid-ABC-transporter-permease-subunit
MPKFQPDKGVDKRWNIGFFLAILLGGQVIVRLLKGKMPKKRDLLEQMATVGVDSLISVLLIAFFAGMIFTIQTARELVKFQAINALGGAFALAFCRELAPVLTASIIAGQVGSAYAAEIGEMQVTDQIDALYMLKTNPIDYLVMPRVFACCLMLPILTIIALVTGIAGGVCVAVYFYNMPPGVFLNSVRNFLELRDLLSIAVKSLVFGAMVALIGCGWGLTTIGGAKGVSRATTSTVVNCWVSIFVVDFFLSLAIFQKVG
>NC_019753.1|WP_015202089.1|1171442_1171844_-|hypothetical-protein
MTGLDLEQEIGKMARAMMARNTTIGDALIAYLRTQLTEEEVAGIVLVSLERLLWLDGDLFLWTLQNFLPQSILNEMRKITTVTLCKQLIGKNFMLGEDFSVNAHGQLLLNTEAKRAILPNLKSSELSPVTSVF
>NC_019753.1|WP_015202090.1|1172600_1173413_+|carbon-nitrogen-hydrolase-family-protein
MKSYLAAAIQMTSQPDLEKNLVQAEELIDLAVRQGAELVGLPENFPFLGLEEDKIAQAEAIAQASEKFLKTMAQRYQVTILGGGFPVPVGDGKVYNTALLIDHNGKELARYEKVHLFDVNVPDGNTYRESNTVMAGLKLPPVYHSQTLGTVGLSVCYDVRFPELYRHLAHQGADIMFVPAAFTAYTGKDHWQVLLQARAIENTCYVIAPAQTGRHYATRQTHGHAMIIDPWGTILADAGDQPGIAIAEINPTRLEQVRRQMPSLQHRVFV
>NC_019753.1|WP_015202091.1|1173729_1174137_-|DUF1311-domain-containing-protein
MFKKSIATTILLATGFLSVPASLILAAPPEIIAQRINCNNPRSTVEEKYCAGIAYEAVDKKLNQVYQQLKSKLTGTEKQRLVESQLAWIKYRDTTCDFETYSSRNGTGYGVFLNECLQRITQERTNDLRQYISGR
>NC_019753.1|WP_015202092.1|1174372_1175770_-|DUF3370-domain-containing-protein
MFLPKKRLYSLLPLFLIFPLAQTTPMPTPAPVQQEVVQPGEVRALPGKLDNVLVFNSNSPELVQKEGILLSTFPAVGKSVPTAHLNFPVTGRFDIFAHHIAKATSPDDLRTLYLGVILHNPNSKPVTVDVLQAASYLSQPDAPFIELPSYVENPLGTVYSGPGSRVMDDVLRGKRQADIPSKLIIPPGTSQLLMNHPIPVKTLTPPLNGRSALIRLRSDRSVYIASLGMYARQNPDGSERAPNLQEWQGLLDNGDLASPRDRAPTPPQQTTGSMIYGRVAGVALGSQWQAQLTDNSKSKVLTIPQPGQAFSYALSTIPRGSLGTNQIQSAPILARYPDTAYLAHGNYGIQYSLSLPLANNTSKSQTVTLAIQTPLKQDKLKDGLVFLQPPASQTFFRGTVQVSYRDNRGLLSKRYVHLVQKRGQQGEPLVKLDLSAGDRKLVQVDFLYPPDASPPQVLTVKTINN
>NC_019753.1|WP_015202093.1|1175770_1176373_-|hypothetical-protein
MNTKILLTSFEIWLPHHTSNSSDDLLEELTKIDDLPYSLYFLRQLPVNIEEASSRVIAKVNKLQPDVIICCGMAEKNQKLTIESQATLQANTLKTTVDLENLLSDLTDTVISNDAGKFVCEGLYYSVLKELQTQQTASKSLNKDKRSCVFVHVPILTPDNLPVIVDDFRLILQKLALFTINNYQLTMTNRQSPVPNHQSP
>NC_019753.1|WP_015202094.1|1176496_1177126_+|imidazole-glycerol-phosphate-synthase-subunit-HisH
MSVIAVVDYGMGNLHSVCKGLEKAGTTPKVTNSAKEIAQADAVVLPGVGSFDPAVKQLRSHDLVEPIKDAIASGKPFLGICLGLQILFDSSEEGIEPGLGIIAGTVRKFKSEPDLTIPHMGWNQLQITQQTSVWDQLSDQPWVYFVHSYYVDPSDRAVTAANVTHGSQTVTAAIRRDNLTAVQFHPEKSSTTGLQILSNFVQQTLTINN
>NC_019753.1|WP_041226379.1|1177202_1177769_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MSLRIYGNRQLKTLPGLETRPTPGRVREAIFNIWQGKIDGCRWLDLCTGSGSMGAEALCRGASLVVGIEQSKSACSIIQENWQKVAREEQKFQVLRGDVVQRLKTLAGQEFDHIYFDPPYASNLYQPVLEAIAGYQLLASTGELAVEHSPNKWQVEPVPHLEIDREKVYGNTAVTFYIPSLLPRLYCI

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Crispr_ID: NC_019753_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_8

1339615-1339713

TypeV-U4

Consensus_repeat	Method
TTAGCTGCAATTGCGATGCTTCTGCTGGTTCATCTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019753_8

>merge|NC_019753|8|1339615-1339713|CRISPRCasFinder
TTAGCTGCAATTGCGATGCTTCTGCTGGTTCATCTAGTAACGCCTCCAAATCATCAAACTCATTTAGCTGCAATTGCGATGCTTCTGCTGGTTCATCTA

>NC_019753|8|7|1339615-1339713|CRISPRCasFinder
TTAGCTGCAATTGCGATGCTTCTGCTGGTTCATCTA	GTAACGCCTCCAAATCATCAAACTCAT
TTAGCTGCAATTGCGATGCTTCTGCTGGTTCATCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015202224.1\|1352380_1353238_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
NC_019753.1\|WP_015202217.1\|1343189_1346165_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|214599
NC_019753.1\|WP_015202219.1\|1346771_1347137_-\|response-regulator	unknown	unknown	gnl\|CDD\|381164
NC_019753.1\|WP_041225954.1\|1332576_1333020_+\|photosystem-II-protein-PsbQ	unknown	unknown	gnl\|CDD\|274404
NC_019753.1\|WP_015202220.1\|1347273_1348548_-\|response-regulator	unknown	unknown	gnl\|CDD\|381129
NC_019753.1\|WP_015202222.1\|1349676_1350306_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202213.1\|1333443_1333845_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350220
NC_019753.1\|WP_015202223.1\|1350988_1351900_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NC_019753.1\|WP_015202208.1\|1330514_1330937_+\|DUF393-domain-containing-protein	unknown	unknown	gnl\|CDD\|225556
NC_019753.1\|WP_041225955.1\|1335245_1337321_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224422
NC_019753.1\|WP_015202218.1\|1346234_1346765_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238374
NC_019753.1\|WP_015202226.1\|1353621_1354596_-\|lipoyl-synthase	unknown	unknown	gnl\|CDD\|237261
NC_019753.1\|WP_041225956.1\|1349069_1349456_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319940
NC_019753.1\|WP_015202212.1\|1333252_1333453_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202210.1\|1331667_1332450_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|178633
NC_019753.1\|WP_015202207.1\|1329548_1330262_-\|pirin-family-protein	unknown	unknown	gnl\|CDD\|380375
NC_019753.1\|WP_015202206.1\|1328870_1329359_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202225.1\|1353381_1353525_-\|photosystem-one-PsaX	unknown	unknown	gnl\|CDD\|369686
NC_019753.1\|WP_015202214.1\|1333904_1335008_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|334462
NC_019753.1\|WP_015202209.1\|1330976_1331402_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015202224.1\|1352380_1353238_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	4.20445e-75
NC_019753.1\|WP_015202217.1\|1343189_1346165_-\|HAMP-domain-containing-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	3.80338e-76
NC_019753.1\|WP_041225954.1\|1332576_1333020_+\|photosystem-II-protein-PsbQ	gnl\|CDD\|274404	TIGR03042, hypothetical_protein, photosystem II protein PsbQ. This protein through the member sll1638 from Synechocystis sp. PCC 6803, was shown to be part of the cyanobacteria photosystem II. It is homologous to (but quite diverged from) the chloroplast PsbQ protein, called oxygen-evolving enhancer protein 3 (OEE3). We designate this cyanobacteria protein PsbQ by homology. [Energy metabolism, Photosynthesis].	1.05719e-49
NC_019753.1\|WP_015202220.1\|1347273_1348548_-\|response-regulator	gnl\|CDD\|381129	cd17602, REC_PatA-like, phosphoacceptor receiver (REC) domain of PatA and similar domains. Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.	5.31784e-41
NC_019753.1\|WP_015202213.1\|1333443_1333845_+\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350220	cd09872, PIN_Sll0205-like, VapC-like PIN domain of Sll0205 protein and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Synechocystis sp. (strain PCC 6803) Sll0205 protein and other uncharacterized homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	9.9672e-49
NC_019753.1\|WP_015202223.1\|1350988_1351900_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	4.36251e-84
NC_019753.1\|WP_015202208.1\|1330514_1330937_+\|DUF393-domain-containing-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	9.44703e-31
NC_019753.1\|WP_041225955.1\|1335245_1337321_-\|S9-family-peptidase	gnl\|CDD\|224422	COG1505, COG1505, Serine proteases of the peptidase family S9A [Amino acid transport and metabolism].	0
NC_019753.1\|WP_015202218.1\|1346234_1346765_-\|hypothetical-protein	gnl\|CDD\|238374	cd00732, CheW, CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.	1.52792e-31
NC_019753.1\|WP_015202226.1\|1353621_1354596_-\|lipoyl-synthase	gnl\|CDD\|237261	PRK12928, PRK12928, lipoyl synthase; Provisional.	0
NC_019753.1\|WP_041225956.1\|1349069_1349456_+\|VOC-family-protein	gnl\|CDD\|319940	cd08352, VOC_Bs_YwkD_like, vicinal oxygen chelate (VOC) family protein Bacillus subtilis YwkD and similar proteins. uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Bacillus subtilis YwkD and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	4.97596e-77
NC_019753.1\|WP_015202214.1\|1333904_1335008_+\|FAD-binding-oxidoreductase	gnl\|CDD\|334462	pfam01266, DAO, FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.	6.23993e-56
NC_019753.1\|WP_015202207.1\|1329548_1330262_-\|pirin-family-protein	gnl\|CDD\|380375	cd02910, cupin_Yhhw_N, Escherichia coli YhhW and YhaK and related proteins, pirin-like bicupin, N-terminal cupin domain. This family includes the N-terminal cupin domains of YhhW and YhaK, Escherichia coli pirin-like proteins with unknown function. YhhW is structurally similar not only to human pirin but also to quercitin 2,3-dioxygenase (quercitinase). Although the function of YhhW is not completely understood, YhhW and its human ortholog have quercitinase activity and are likely to play an important role in transcription and apoptosis. This N-terminal cupin domain of YhhW has a metal coordination site and is thought to have catalytic activity while the C-terminal cupin-like domain has diverged considerably and has closer alignment with C-terminal pirin. YhaK is found in low abundance in the cytosol of E. coli and is strongly up-regulated by nitroso-glutathione (GSNO). There are major structural differences at the N-terminus of YhaK compared with YhhW; YhaK lacks the canonical cupin metal-binding residues of pirins and may be involved in chloride binding and/or sensing of oxidative stress in enterobacteria. YhaK showed no quercetinase and peroxidase activity; however, reduced YhaK was very sensitive to reactive oxygen species (ROS). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	1.25295e-81
NC_019753.1\|WP_015202210.1\|1331667_1332450_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|178633	PLN03084, PLN03084, alpha/beta hydrolase fold protein; Provisional.	7.70681e-50
NC_019753.1\|WP_015202225.1\|1353381_1353525_-\|photosystem-one-PsaX	gnl\|CDD\|369686	pfam08078, PsaX, PsaX family. This family consists of the PsaX family of photosystem I (PSI) protein subunits. PSI is a large multi-subunit pigment protein complex embedded in the thylakoid membranes of green plants and cyanobacteria. PsaX is one of the 12 protein subunits found in PSI and these subunits are arranged as monomers or trimers within the membrane as shown by the structure of the trimeric complex from Synechococcus elongatus.	2.75234e-10
NC_019753.1\|WP_015202219.1\|1346771_1347137_-\|response-regulator	gnl\|CDD\|381164	cd19937, REC_OmpR_BsPhoP-like, phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators. Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.07448e-39

>NC_019753.1|WP_041225955.1|1335245_1337321_-|S9-family-peptidase
MPDTTKSISYPTTQTVNQVDDYHGTKVSDPYRWLEDVDSQETKAWVEAQNQVTFDYLNQIPARSQIKQRLTQLWDYEKFSIPFKEGDRYFYFKNDGLQNQSVLYTLTSLDSEPKVLLDPNKLSEDGTVALAGIAISENGKLMAYGLSTSGSDWQEWKVRDVETQEDISDHINWIKFSGASWTKDNQGFFYSRYDQPNEATKLEDINYFQKLYYHKIGTPQSEDVLIYHRPDQKEWGFNGGVTEDGRYLIISVWQGTDPKNLVFYKDLADANSQVIELISDFEASYSFIDNDGSVFLFQTDLDAARGRAIAIDINNRQKENWREIIPQATETLESIGILNNQLLADYLKDARSQIKIFNLNGEFVREVTLPGIGSAGGFGGKRWDTETFYSFTSFTTPATIYRYDMTTGESTVFRQPQVDFNPEDYETKQVFYSSKDGTQVPMFITHKKGLQLNGNNPTYLYGYGGFNVSLTPSFSVGVIVWMEMGGVYAVPNLRGGGEYGEEWHQAGTKLNKQNVFDDFIAAAEWLIANNYTSPAKLAISGGSNGGLLVGACMTQRPDLFAAALPAVGVMDMLRFHKFTIGWAWTSDYGSPDHPEEFQALYAYSPLHNLKPGTSYPATLITTADHDDRVVPAHSFKFAAALQEAHKGEQPVLIRIETKAGHGAGKPTAKIIEEIADKWAFLVSILDITVGA
>NC_019753.1|WP_015202214.1|1333904_1335008_+|FAD-binding-oxidoreductase
MSRIVIIGCGVVGAAIAYELSLVPNLSITVIDQQPPAQGATGAALGVLMGVISHKVKGNAWRMRQSSIQRYESLIPELEAITGYKIPFNRQGILKLCFEGEDLTKWEKLIEIRQSQGWDLEIWDSSQLLLNCPQLSSNNIIAGVYSPQDRQLDPTALTNALVEAAKYNGVNFQFGVKVDNFKSCKSENLDIDVCREIQTTTGKLTADWFVVAAGLGSTPLTASLQQAVDIRPVLGQALHLRIKNPLGDANFQPVITGNDVHIVPLSNEEYWVGATVEFSSNHSDIVPDAALLEQVMQQAIAFCPDLAEATVLKSWSGLRPRPEARPAPVIGHLPSYSNVLLATGHYRNGVLLAPATAQAIREAILSS
>NC_019753.1|WP_015202213.1|1333443_1333845_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MGISYLIDTHILLWWLFDDPKLNTTCQEIIRNPNHRILVSSVSAWEIATKYRIGKLPEAKKLVEQYSQILHQAKFIELAITNAHALRAGSLAIAHRDPFDRMIMAQAELESLPVITYDQAFQTGLIQVIPDLK
>NC_019753.1|WP_015202212.1|1333252_1333453_+|hypothetical-protein
MLIQKIVQELQEIPEDKLAELYDLIHYFRLGLSQELTEPRTPGLLKGQLGDAFFEPLPEEELQQWE
>NC_019753.1|WP_041225954.1|1332576_1333020_+|photosystem-II-protein-PsbQ
MARYRSILALILAFVATFVVSCSSPTEVKAKTYTPTQIEQIEQYAQGISALRDRLPELATMIENRDWNNVESFIHGPLGDIRARMSALARQLMPDAQKAALETAKDVFGHFIKIDESAQTGSYTQAIRNYAELIKDFDAFLNQIPKA
>NC_019753.1|WP_015202210.1|1331667_1332450_+|alpha/beta-fold-hydrolase
MSDNGKLPVLLLHGLPSLSYSWSAVMPALAEKGFRAIAPDWIGFGLSAKPDRRDFAYTPDAFINALAEFIQALEIERFFLVVQGFLGSVGIQYALRHPNQIERLTILNAPLSPSAKLPWKIKQLGIPLVGEMLTQDPLLVDRTLESGSRYRVSDADLDVYRRPFLKSSDAGRSLFATVQNLQLKQSMAEITSSLNAWSIPTQLIWGIKDPWLPLTEAEYLANSLKQVELIKLEEGGHYPQDHWSAQVSDALVYFLRRQVV
>NC_019753.1|WP_015202209.1|1330976_1331402_-|hypothetical-protein
MNAAEQATNIEYATKIAAVVNLFKSEFPDAKVDLKPWVNDPDTRELVDPDSIDIGFHFPGWSKRFQSRSILVQIRFYEDPLDAAHRVIGVEAAGFDHRGKQWRLSTVEQWRFEGASQPIAEVGEKLKHFCRQVFELFNNSN
>NC_019753.1|WP_015202208.1|1330514_1330937_+|DUF393-domain-containing-protein
MNYYVIYDGNCNLCVNLVQQLEILDKGNLFEYLPMQDQEALNNFGITQQDCEMGMILIDANAPRNRWQGSDAAEEIARLLPVANLIVDAYRAVPGLKWLGDRAYEQIRDNRYTLFGKRTTTYHSAFPVGGCQSGSCSINN
>NC_019753.1|WP_015202207.1|1329548_1330262_-|pirin-family-protein
MSQVKTIEIRKADQRGHFKIGWLNSYHTFSFGNYYDPKHMGFRALRVINDDRVAPSGGFDTHGHRDMEIITYVLEGALEHRDSLGTGAVIYPGDAQRMTAGTGIRHSEFNHSQTEPVHLLQIWILPEQQGLPPSYEQQSIPLEEKQGKLRLIAGRNGGEGAVKVHQDMQLYASVLTPGDRISYDLKANRYAWLQIALGGATLNGHTLAEGDGVAITGEEKLEISTEVGGEILLFDLA
>NC_019753.1|WP_015202206.1|1328870_1329359_+|hypothetical-protein
MLNFARVTTILGGFSVLIFSIPVLTQEQPTTISVLPDTQPNITFNVTTKAGQCPKTVSLWNLSRYYEGGVEHTAIADTLPIAGNPELISSTNKFVQFKAPLTKAYELCNGLATSETRTYYSFRFRDRHVYFKVNIKNIPRYSLVSDQKVIESRPVVRWQVAD
>NC_019753.1|WP_015202217.1|1343189_1346165_-|HAMP-domain-containing-protein
MTSSTDYAQEYQQAEKAYLQGNYNQAAEIVDQLVQKLPDDPSSHLLRGHIYCYGLQQYDVAEQQYDLVKTLTSEPEFLEYANNGLEYARACSTSADYAEQGGAIEEAPAHQNYTDEDANLAESSFTPYSEELETGYLGEFDLGEINFDDDSEQNFDQYGSSDHFSNPFNNRLDESPESSHIQEDFLDPFAFGQSPNNDSAIPSTGTDFNFNPIEESNDFFPMDAFADLDDDADGGETLFLNPPDAPNGKGFIITPADTLDTTPDPTDAFHQDDLGNSYDFESHVDPNATDYGNSNGNYSNAPPSNHFPSERPVYEDETLLMRAEDLENTFAAPSGNFATDYQPGSEDTNLFVVDEYDSEEATQHFSSAQNGFTPPEAFDFDAFDEAFASDVDDPVSGFGDSTAIPAHQTQAGFLDAFDDFDDFGSISDFDPAGQDGLDLSAGFGRSDTRGFSSTNTTGGLGATVPSKIGGDEDEIFSITSTSGIGSGKGENLPSFTQSSAGHVEPNVTVDQSWLAPFENAPLNKKNLITAAAAGIVSAVAVATVSFMAGTTAPKASQATLIPQLRNTSVLMTLAAGFASFGTTLFLGRVATKQLSRSTSNLQAQFEEICQGNLNARATVYSEDDFGRLATGFNQMGHVMMTTIGELQRKAIELEQAKEDLQRQVIRLLDDVEGAARGDLTVQAEVTADVLGAVADSFNLTIQNLRQIVQQVKVAAKQVNKGSKDSEVFARNLSSDALRQAEELAVTLNSVQVMTDSIKRVADSAKEAEEVARTASATALKGGEAVERTVAGILEIRETVAETTRKVKRLAESSQEISKIVALISQIASRTNLLALNASIEAARAGEAGRGFAIVADEVRQLADRSAKALKEIEQIVLQIQSETGSVMTAMEEGTQQVIQGTRLAEQAKRSLDDIIQVSNRIDALVRSITADTVEQTETSQSVAHVMQSVELTAQETSQEAQRVSGALGNLHGVAQDLLNSVERFKVDADGK
>NC_019753.1|WP_015202218.1|1346234_1346765_-|hypothetical-protein
MVGNLDFLPGSGQDNSPEMQELQSPEGELHLRFYVPSENEFALPAIGIREIISTPPDRITAIPNASPLLLGTLNWRGQVIWVADLGQFLGDTATLNTDRAEIPVIVVEDQDTMIGLAVDRIFGTDWLDIEQIQMTTNVPDSMAPFLRGEWVKGEEHKKYLRLLDQLAILRSARWAA
>NC_019753.1|WP_015202219.1|1346771_1347137_-|response-regulator
MSTVLVVEDSTAQRTMIKDLLKSSGLIVTEATDGVEALEQILKSRPDIVVLDIVMPRMNGYEVCRRLKADPKTQSVPIVMCSSKGEEFDRYWGMKQGADAYIAKPFQPTELIGTVKQLLRG
>NC_019753.1|WP_015202220.1|1347273_1348548_-|response-regulator
MQGTLNEIDIRSILQLIELGQRTGELLLEACAYPASSSRGDTNIFKASDRFPSHAGQFWLVFFINGQIAYAADNDGSLWRLRDYLRRYGVESALDQLQLPSIACNNAPEYGYLWALMEKHILTPAQGRSILQSMVNETLFDLLSLHQGFFIFEMGTALAPQLTTLEITPLLTKIMKQVQEWKQFHPYIQSPNQCPVIANREQLSVSLPQKAFATLNTCADGKTSLRQISRYLNRDILTVAGAIYPYIQKGWVQLLMKQDQKISNQNNQSQAIQTSTVTQIICIEDDVAIGKAVEYILQQHGYQVTVIKNPIKALTLAFELQPQLILCDIAMPSLDGYEICAMLRQSSDFRHTPLVMLTGMDGFIDRVRATMVGATDYLTKPFGESELLMLLEKYLGSKKRTNLKPTSLFPDLEQTIKDPDVRAG
>NC_019753.1|WP_041225956.1|1349069_1349456_+|VOC-family-protein
MKTTGIHHVAIICSDYQKSKSFYVYTLGFTIIKETFRAARNSYKLDLQVGNGDRIELFSFPNPPARPSTPEACGLRHLAFKVNDINEAVADLQSHGVAVEDIRIDELTRKKFTFFKDPDNLPLEIYED
>NC_019753.1|WP_015202222.1|1349676_1350306_-|hypothetical-protein
MKKTFLTTTLLTLLSLACASVSHSAIATAQLKNSSPVNTPSNYRNKIKQSTARFSPKQIQILKSVGMKIVVPTYIPSGFKIETLSNNSDKNYKGYTVIYRRNDNACFSIEAINGGIGDEPDLEHTLPYNSPLFGKGILNYGKYTDIYLRKQSPLSEMTTRWMEPKNYQAFYRFNGANWYSSDKGKPKCNKDISPTEAVKVINSLQYLKF
>NC_019753.1|WP_015202223.1|1350988_1351900_-|cation-transporter
MNRANARSYVILSIGAAVITIALKFAAYYFTGSVGLFSDAAESLVNLAAALVAFWALTFAAQPPDAEHTFGHSKAEYFSSGVEGGLILIAAGSIAVSATNRLIHPQPIEQLGLGVGLSLVATAVNGGVATILLKAGRRLRSITLRADAHHLFTDVWTSFGVLLGLLLVKLTGWLILDPIIALVVAVNIVWVGVKLLRETAAGLLDSALPAESQKIITDVLAPYQQQGIVFHALRTRVAGSVQFVSFHVLVPGDWTVKRGHELCEEIELTISRVLPDTNVTTHLEPIEDPASWNDQDLYRRKNI
>NC_019753.1|WP_015202224.1|1352380_1353238_+|branched-chain-amino-acid-ABC-transporter-permease
MDAQLLVNGIAVGSIIALAAVGLTLTYGILRLSNFAHGDFMTLGAYLTWLANRSGVNIWLSMILGAAVTVGAMLLCEKVLWKPMRDRRADGTTLIIISIGLALFIRNGIILIWGGDNQSYDLPIASALSIAGLRIPQNQLIVMGLAVVAIVGLHFLLQNTKIGKAMRAVADDIDLARVTGINVERVVLWTWVITGVFTALGGSMYGLVTGVRPNMGWFLILPMFASVILGGIGNPYGAIAGALVIGIAQELSVPFLGSQYKLGVALLIMVLILLFRPQGLFKGTI
>NC_019753.1|WP_015202225.1|1353381_1353525_-|photosystem-one-PsaX
MTAQAKKPTGSVTKTSNPPYPFRTTVLLILLAGNFLVAGIYFHLINP
>NC_019753.1|WP_015202226.1|1353621_1354596_-|lipoyl-synthase
MDLLSETEQHLTNQAAKAGWRAPLGDAQERQIEALPSWLKRSIGKASEISTVQKIIKQREIHTICEEGRCPNRGECYSQKTATFLLMGQTCTRACAFCQVDKGHAPMPLDPQEPQKVAESVQLLGLRYVVLTSVARDDLPDQGASWFVKTMAAIRKLNPETQIELLTPDFWGGRVTGEMTQADQQRQRVETVVKAKPACYNHNIETVKRLQGRVRRGAQYERSLDVLRFVKEIDSTIPTKSGLMLGHGETEPEIIAAMVDLRNAGCDRITLGQYMRPSLEHLPVQKYWTPEEFDRIGAIARDLGFAHVRSAPLVRSSYHAGESA

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Crispr_ID: NC_019753_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_9

1564327-1564437

Orphan

Consensus_repeat	Method
GGAATTATAGTTGGAGCTAGAGTTGGAGTTGCATTTGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019753_9

>merge|NC_019753|9|1564327-1564437|CRISPRCasFinder
GGAATTATAGTTGGATTCGGAATTATAGTTGGAGCTAGAGTTGGAGTTGCATTTGGAATTATAATTGCATTTGGAATTATAGTTGGAGCTAGAGTTGGAGTTGCATTTGGA

>NC_019753|9|8|1564327-1564437|CRISPRCasFinder
GGAATTATAGTTGGATTCGGAATTATAGTTGGAGCTAGA	GTTGGAGTTGCATTTGGAATTATAATTGCATTT
GGAATTATAGTTGGAGCTAGAGTTGGAGTTGCATTTGGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015202404.1\|1576963_1577833_+\|zinc-finger-SWIM-domain-containing-protein	unknown	unknown	gnl\|CDD\|226729
NC_019753.1\|WP_015202405.1\|1577973_1578309_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202399.1\|1565271_1566606_-\|sorbosone-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|225044
NC_019753.1\|WP_015202397.1\|1562249_1564031_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
NC_019753.1\|WP_015202408.1\|1580033_1580219_-\|proto-chlorophyllide-reductase-57-kD-subunit	unknown	unknown	gnl\|CDD\|369836
NC_019753.1\|WP_015202401.1\|1567423_1569265_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_019753.1\|WP_015202390.1\|1552605_1554576_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|237862
NC_019753.1\|WP_015202396.1\|1560154_1561498_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_019753.1\|WP_015202400.1\|1566821_1567391_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202394.1\|1558070_1559093_+\|zinc-ABC-transporter-solute-binding-protein	unknown	unknown	gnl\|CDD\|238557
NC_019753.1\|WP_015202391.1\|1554793_1555897_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_041225968.1\|1579200_1579518_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202393.1\|1557201_1557948_-\|metal-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224046
NC_019753.1\|WP_015202406.1\|1578428_1579157_-\|DnaJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|224276
NC_019753.1\|WP_015202395.1\|1559569_1559998_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366351
NC_019753.1\|WP_015202392.1\|1556154_1557033_-\|metal-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224033
NC_019753.1\|WP_157462282.1\|1550918_1551095_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202389.1\|1551177_1552587_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224136
NC_019753.1\|WP_015202402.1\|1569604_1571758_-\|polyribonucleotide-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|236995
NC_019753.1\|WP_015202403.1\|1572249_1576863_+\|helicase	unknown	unknown	gnl\|CDD\|223627

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015202404.1\|1576963_1577833_+\|zinc-finger-SWIM-domain-containing-protein	gnl\|CDD\|226729	COG4279, COG4279, Uncharacterized conserved protein [Function unknown].	1.23366e-99
NC_019753.1\|WP_015202406.1\|1578428_1579157_-\|DnaJ-domain-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	7.54425e-31
NC_019753.1\|WP_015202399.1\|1565271_1566606_-\|sorbosone-dehydrogenase-family-protein	gnl\|CDD\|225044	COG2133, COG2133, Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism].	2.42856e-85
NC_019753.1\|WP_015202397.1\|1562249_1564031_-\|pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
NC_019753.1\|WP_015202390.1\|1552605_1554576_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|237862	PRK14948, PRK14948, DNA polymerase III subunit gamma/tau.	0
NC_019753.1\|WP_015202396.1\|1560154_1561498_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	1.22496e-169
NC_019753.1\|WP_015202394.1\|1558070_1559093_+\|zinc-ABC-transporter-solute-binding-protein	gnl\|CDD\|238557	cd01137, PsaA, Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	1.23692e-101
NC_019753.1\|WP_015202408.1\|1580033_1580219_-\|proto-chlorophyllide-reductase-57-kD-subunit	gnl\|CDD\|369836	pfam08369, PCP_red, Proto-chlorophyllide reductase 57 kD subunit. This domain is found in bacteria and plant chloroplast proteins. It often appears at the C-terminal of Nitrogenase component 1 type Oxidoreductases (pfam00148) and sometimes independently in bacterial proteins such as the Proto-chlorophyllide reductase 57 kD subunit of the Cyanobacterium Synechocystis.	2.95263e-16
NC_019753.1\|WP_015202393.1\|1557201_1557948_-\|metal-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	5.88823e-100
NC_019753.1\|WP_015202395.1\|1559569_1559998_+\|hypothetical-protein	gnl\|CDD\|366351	pfam00875, DNA_photolyase, DNA photolyase. This domain binds a light harvesting cofactor.	3.21082e-09
NC_019753.1\|WP_015202401.1\|1567423_1569265_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.21029e-85
NC_019753.1\|WP_015202392.1\|1556154_1557033_-\|metal-ABC-transporter-permease	gnl\|CDD\|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	1.02412e-70
NC_019753.1\|WP_015202389.1\|1551177_1552587_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|224136	COG1215, COG1215, Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane].	9.18719e-62
NC_019753.1\|WP_015202402.1\|1569604_1571758_-\|polyribonucleotide-nucleotidyltransferase	gnl\|CDD\|236995	PRK11824, PRK11824, polynucleotide phosphorylase/polyadenylase; Provisional.	0
NC_019753.1\|WP_015202403.1\|1572249_1576863_+\|helicase	gnl\|CDD\|223627	COG0553, HepA, Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair].	1.3024e-101

>NC_019753.1|WP_015202397.1|1562249_1564031_-|pyruvate-kinase
MQLRDSLRRTKIVATIGPATSSPEVLRALIQAGATTLRLNFSHGTYEDHQRSIRLIRQTAFELNQPVGILQDLQGPKIRLGRFETGPISLKKGDRFTLTSNPVPGTEKISSVTYEPLADEVPEGATILLDDGKVEMIVEKVDKTTRELHCRVVVGGTLSNNKGVNFPDVYLSIKALTDKDRKDLVFGLDQNVDWVALSFVRNPQDILEIKELIASAGKQTPVIAKIEKHEAIEQMEAILCLCDGAMVARGDLGVELPAEDVPILQKRLITTANRLGIPIITATQMLDSMVNNPRPTRAEISDVANAIIDGTDAVMLSNETAVGSYPVEAVETMARIAVRIEKENLFRQVKDSRKSIPNAISHAVGQIAEQLHAAAIMPLTKSGATARNVSKFRPQTPILAITPHVDVARQLQLVWGVKPLLVLDLPSTGQTSQAAINVALEKNLLVEGDLIVMTAGTLQGVSGSTDLIKVEVVTAVLGKGIGIGQGAVSGRARVAKSAIEVNNFKHGEILVTRNTNVDYVELIRKASGIITEDDSLTSHAAVIGLKLGVPVIVGVKNATEVIRDGAILTLDTQRGIIYSGAMSAASATEVNTR
>NC_019753.1|WP_015202396.1|1560154_1561498_-|NAD(P)/FAD-dependent-oxidoreductase
MPEELTNQSAHHVVIIGGGFGGLYAAKSLKNAPVKVTLIDKRNFHLFQPLLYQVATGTLSPADISAPLRGILSNNKNTQVAMGEVLDIDPEQQKLILQNEELNYDTLIVATGVSHHYFGNEQWADVAPGLKTVEDALEMRRRIFMAFEAAEKESNPEKRRAWLTFVVVGGGPTGVELAGALAEIAYSTLKNDFRNIDTTEAQILLLEGIDRILPPYPPELSAKTEASLVDLGVTVRTKTLVTNIENDVVTIRQGEQIEEIPAKTILWAAGVKASRMGQVLAKSTGAELDRTGRVVVQPDLSVAGHPNIFVIGDLANLADKDGKPLPGVAPVAIQEGKYVANLIKSRLTAKSLPAFCYQDYGSLAVIGRNAAVINLPFLRLTGFIAWLIWLFVHIYYLIEFDNKVVVFIQWGWNYLTRKRGARLITGKTSLPLVAVEEASNSRTPLEV
>NC_019753.1|WP_015202395.1|1559569_1559998_+|hypothetical-protein
MKKPIIWVHGDCLSSDHPALKAHPNALAIWVWDEALLEEWKISLKRLVFIYESLLELPVIIRRGDVAAEVIAFAKEHDADGVVTAESPSPRFEAICGEIERSLPLEILPVKPFLNYDGYIDLKRFSRYWRVAAKYVFTSTSR
>NC_019753.1|WP_015202394.1|1558070_1559093_+|zinc-ABC-transporter-solute-binding-protein
MNHNVNKKFPFYAAVGISLLLVGCNPGTQSNNLSNSNANSTNKLPTVVATHSVLCDLAKLIAQNTINLTCLIQPGVDVHVYKPTPQDRKAIEKAQLILYGGYNFEPELIKIINASNQAATKVAVHEVAVPKPLMEEDNHHEESEKSAKHEIVPNPHIWHNAQNGIRMVEVIREQLTKLSPVNFNVYAANAHQLSDKLKQLDAWTKAQINTIPLKQRKLVTTHESLNYYANAYGLTIEGALQGLSTEEKPTALRVKELVTEIKNTGVPTIFTEATGNDKVIRTVAKEAKVKVAEQGLFVDSLGTPGSQGDTYIGMLTSNTCTITTGLGGKCSAFLGNTLNK
>NC_019753.1|WP_015202393.1|1557201_1557948_-|metal-ABC-transporter-ATP-binding-protein
MLEVQNLAVNYRGVSALQGVSFSIAPGQLVGLIGPNGAGKSTLVKAMLGLIPTVSGFVRFNQRPLKQQRQQVAYIPQRSQIDWDYPVTVWNVVLMGRTFDRGLFSRISRQSQQLAENALQRVGMWELRHRQIGELSGGQQQRVFIARAIAQQAEIFLFDEPLIGIDKKTEALIFEVFSDLKAERKTLLVSSHQWGQDLAKYDSLLLLNQQLVAVGLPQEVMTIENIQRAYGQGISNPVKQSLETLYFC
>NC_019753.1|WP_015202392.1|1556154_1557033_-|metal-ABC-transporter-permease
MLDWLIEPLNYEFIRNAMMMGILVGILCPIVGSYLIVQRMALLGDVIAHAVLPGLAIAFFLGIDILIGAFISGIFSTFVIAWIKSQSRVKVDAAMALTFSSFFSLGITLITLLKSKLDLENLLFGDILGVTITDVLRTGAIALIVLTFVKIFYKQLLFYTFDPLGAEAMGLPVNYLHLGLMAAITLTIVASMQSVGVVLVISLLVGPGITAYLLVKELHLMMILGAILGMITSISGVYSSYYLNIPSGPAIVLFSFGLFLLAILFSPSQGILTRPTSSNYYTQILRKLRNLI
>NC_019753.1|WP_015202391.1|1554793_1555897_+|hypothetical-protein
MLQGIWKSLVNGFQGLFGVGNTQKSTALLLPSQPLPPLEDADYEYLLMQLIEGVAHGWQQQRILKFFDALEYRTTQEEWLAWLRRFGDRLLTSSVPNNDLAARMVQLGEIGCGEIGVMAYDIGMQLLTRQNPTDQTWDLDSPQVVYVDAEEMTLEQSFDDWNDSNPDLIYSEIEESQQPPAKIDSPPVIYVDGENTTEVNPNLDPWNDSSVELVSSETPQSQQTSVQIDSPQVIYVDAEKITDVNPNVDPWNDTSPDLVSPQTEESQPPAKLDSPQVIYVDAEKTTDVNPNIDPWNDYNPDLLSQQTEESQEFSIDELLFMLEQNPALAKEMSEQLQINNTNPEAILEAFIQQLDKDIQAQADESQN
>NC_019753.1|WP_015202390.1|1552605_1554576_-|DNA-polymerase-III-subunit-gamma/tau
MNYEPLHHKYRPQTFAQLVGQEAIATTLSNAIRLRRIAPAYLFTGARGTGKTSSARILAKSLNCLSSDVPTSSPCGKCEVCRAIAFGSALDIIEIDAASNTGVDNIRELIERAQFAPVQCRHKVYIIDEVHMLSTAAFNALLKTLEEPPAHVVFVLATTDPQRVLPTIISRCQRFDFRRIPLDPMAQHLRKIAEAENINITDEAVTLVAQMAQGGLRDAESLLDQLSLLAGQVTVEKVWDLTGAVPERDLIVLVQAIAANNAETVLDRARSLMERGREPLVVLQNLAGFYRDLLIAKTAPSRGDLVALTAQTWQQLSQEAKNWDANQILASQKHLKDSEVQIKNTTQPRLWLEVTLLGLLPSAVTYQTPHQPIATSPTPKIEEIRSQTPAKSPPPAPQQTSPPITPVNNPSPTPIASEPVKELPTPEPIPSEAANVSSSQVTEVNSHSLTLEQLWQQVIANIRRPLTKPLVRDHCRLLVFESNFALIGVSSEKLLKTAQSSSQYIEAAFQTVCQHPVKLQFQLAAHTHSKTTTVQEPPRDLHNATEPIARNNDATPANNPSSQAAKAIVEPPKTNSKPAITPPPEKPARESKTDEVTKAAYSLAKFFDGEFVEIVEDLEVNKPARYQQLQAENNIINAAFLDEELEEPQENEYEGF
>NC_019753.1|WP_015202389.1|1551177_1552587_+|glycosyltransferase-family-2-protein
MPDSWAEKNYDGEFDPIDSLLSDDLESDFFQGVAGRRRKAAVLLTAIWSITIGLHLIAWGSWLILGLTCLLGIQAVRVLLARPHPIHTPYPSETSAELPYVSLLVAAKNEEAVISNLVRMLCNQDYPANRYELWVIDDHSTDKTPQLLDKLAKEYEQLHIMHRPAGASGGKSGALNQVLPQTLGEILAVFDADAQVSPDFLRRVLPCFEKKQVGAVQVRKAIANSSVNFWTRGQMAEMGLDTYFQQQRIAISGIGELRGNGQFVRRAALSSCGGWNEETITDDLDLTIRLHLDKWDIEFVEVPAVQEEGVTTALALWHQRNRWAEGGYQRYLDYWRLIASNRMGLLKTLDLLSFMLIQYILPAAAVPDLVMAIARHHLPLLTPLSVMGLTLSFWGMLMGLRRIQKHESGRSSFFVPVLQTLRGSLYMLHWWLIIAGTTARISIRPKRLKWVKTVHQGTDEVWLDVPEQS
>NC_019753.1|WP_157462282.1|1550918_1551095_+|hypothetical-protein
MQCNVWCGYLIYLSEVLPQSSDYLSREQISVSIWTRYDANQLGNHHILVNQKCKEVQQ
>NC_019753.1|WP_015202399.1|1565271_1566606_-|sorbosone-dehydrogenase-family-protein
MKPLRFLLISLLAIAACDSTNASIESQNPKQTDNPAQPKQQNLSKTKNQVTTQPLSPKPIRISIGSLPQPFASNSAFNSPNVIPIPANPSLRVPPGFVVKVFAENLDAPRWLALTPSGDILVTETRQNRIRLLRDTNSDGVADVSKIFAGQQNEINIPFGMTFADGYFFVGNTGEVRRFPYKKGQQQISGTGEKIATLTPGGYNQHWTRNVVASPDGKKLYVSVGSRSNADEEPLPRASVQVINLDGSNQQTFASGLRNPVGLDFHPKTKALYATVNERDGLGDDLVPDYLTRVQQGAFYGWPYAYLKPNLLDPRQLNNGKSKRPDLVSRTKTPDVLFQAHSAALGLQFYDGKTFPEKYRNGAFVAFRGSWNRNQGTGYKLVFAPFDSTGRAKGYYEDFLTGFLVDPSVAETWGRPVGLLVLPDGSLLFTEEANNRIYHVQYRG
>NC_019753.1|WP_015202400.1|1566821_1567391_+|hypothetical-protein
MSNLILKQAVANSTRPSADSMVSALLEAEKNAKRNKVSYSFEQLIGTWRLCFITGTKKTRAKAGIVLGAGRYIPKLIKIKIVYSASQPEENFDLGKVENSVEFGAVKLTLSGITKFLPKKNILAFDFTRMTIQVMGATLYQGYIRGGEKKEQDFLTESVSKQAFFAYFMVEDGMIAARGRGGGLALWSR
>NC_019753.1|WP_015202401.1|1567423_1569265_+|ABC-transporter-ATP-binding-protein
MKKKKFFNAPRFALQRIRQSAALFQYSDRAIRLVWSTSPLLTIIFAVMTLAAGLLPGAIAYVGKLIVDAVIGASNYGLQSDRILALSYVALEALLVALLNGTQRSLAVCQSLLRVLLGQKVNVLILEKALTLDIAYFEDSEFYDLMNQARREASTRPLSLVSRTFKLIQDTLSLITYGGLLLQFSLWAVVVLSVAGIPAFIAETRFAGEAFRLFRWRSPETRQQTYLETLIAREDYAKEVKLYQLGKILLTRYQEIFHRLYGEDRNLTIRRGFWGYLLGLLSTATFYLAYTWIVLETIGGKISLGDMTMYLIVFRQGQSTFSSGLSGVGGMYEDNLYLSNLYKFLEQKVPKSQGKATKGLIPNDGVRFENVSFSYPGSQKPALQGISLHLKPGQKLAIVGENGSGKTTLIKLLTRLYAPSSGRILLDGLDLQAWDITALHRRYAVIFQDFVRYQFTVGENVGVGDVEHLQDQSRWEIAADKGMAKPVIKSMPAGFQTQLGRWFKSGVELSGGEWQKIALSRAFMGTDTDILVLDEPTAAMDAEAEFQIFNHLRTITKNQIVILISHRFSTVRMADTIVVLAGGVVIEQGTHEELLKAEGRYARLFSLQAAGYQ
>NC_019753.1|WP_015202402.1|1569604_1571758_-|polyribonucleotide-nucleotidyltransferase
MVELDKSISFDGRDIRLKVGLLAPQAGGSVLIQSGDTAVLVTATRSTGREGIDFLPLLVDYEERLYAAGRIPGGFLRREGRPPEKVTLTSRLIDRPLRPLFPSWLRDDIQVVASTLSMDELVPPDVLAVTGASIAVMLAKIPFNGPMAAVRVGLVGDDFVINPTYKEIEAGDLDLVVAGSPEGVIMVEAGANQLPEQDIIEAIDFGYEAVRDLIAAQQELLAELGIEMVVEQPPEVDTTVENFIRDRATEPIKVILAKCEADKNVRDAALDEIKESLKTELSELPEEDPIRVAAAANSKILGNTFKDLTKKLMRRQIIEDGIRVDGRKLDEVRPVSCRVGLLPRRVHGSGLFNRGQTQVLSACTLGTPGDAQALADDLHPEDSKRYLHHYNFPPFSVGETKPMRAPGRREIGHGALAERALVPVLPPKEAFPYVIRVVSEVLSSNGSTSMGSVCGSTLSLMDAGVPITKPVSGAAMGLIKEADEVRILTDIQGIEDFLGDMDFKVAGTDTGITALQMDMKINGLSMDIIAKAIDQARPARLHILEKMLAAIDQPRTELSAFAPRLLTMSIDPDMIGLVIGPGGKTIKGITEETGAKVDIDDDGTITVSAVDAEKAKRAINIIQGMTRRLHEGDVYAGRVTRIIPIGAFVELLPGKEGMIHISQLADYRVGKVEDEVAVGDEVVVKVREIDNKGRINLTRLGIHPEQAAAARAAAVSA
>NC_019753.1|WP_015202403.1|1572249_1576863_+|helicase
MAILHGSWLTKPQGGYLFIWGETWRRITSVEIAEDDLRSHPLAMTQEEFIAFLKSRNLTIGKFLETSGSSKAKTDGKHRWKSEAIAFPTPISEETQKYPEYSPKTSDLDLQQCQLKLWQVEGYCLEPLEAIKFLQALPLGSFKATDAYLGGDIRFWSHVCRWSLDLLARSKFLPGINRQLDGTVSACWQPLLDSAVDQARLETFAQQMPTLCRTYQQLEVNNQELTSERIDTAFLALEPKTLIFGCLSNIIDSQCRAAASSLPKSGMNALQNAELIVRQWLQSLASDSSILEADSATIARLETTLRSWTTPIQEHLINFIDQNLEQNQFRTCFILHPPTTGVNEWKLEYCLQAVDNPDFLVNAETIWNNPVEHLVYQDRTIENPQETFLKGLGLAVRLYPLIEPSLHQPQPDSYNLNPIEVYEFIKASAWRLQDSGLGVVIPPSLMPGKGLSGKMGLKIKAEVPNKKERLGLQSLLKFKLELAVGDRTISKAEFDRLMALKTPLVEVNGEWIALQPQDIRAAEAILATRPENLSLSVEDALRLSTGDTKTLEKLPVVSFEASGVLQELITNLTDNQAIAPLPAPANFQGQLRPYQERGVGWLSFLERWGLGACLADDMGLGKCILPHSFVFVNGLIQKAEEIWQANVQDEQFDGEGFWANPKHPLIVNAINEQTGKIILAQIQRLYRQNVQEKLRTIKLKDGSSITITQRHKLLTNKGWTNNLQVGDYVCVPAKIVWEGKPEDPDLVKFLAWQIAEGYEECNRASLKITQKDAATLEELRLILHRFSENYGININRPAVRIRANNRAADLSLNSREYQKFLESRGYKWGKLSAEKSFPPFIMQADLNSAGIFLRNYFDAESAVIHSMRSIEIATASPVLIQQLSVLLRRFGIWMRIQPKQKRATNGTGIFRTYYIGVIGGNSARRFLQEIGFGNPEKQRKLEIICQIASNTNVEGIPASDIVAKAIEITQLPVRHFGMHTTVYINGSQQFSRTSLEKVIAGFDRIISGEAEKEYRQQKLSKWTVKTLERYDQLDLELLTLTQKSLQRLLELEVFYCQIDEIEEIDYQGWVYDFEVSEHHNFVANNILCHNTIQTLAFLLHLKEEEALAKPTLLVCPTSVLGNWEREVHKFSPTLQALVHHGDKRAKGNNFAKAIKGKDLVITSYALVYRDAKSLENISWQGVILDEAQNIKNPEAKQSQAVRKLPTEFKIALTGTPVENRLSELWSILDFLNPGYLGNRQFFQRRFAIPIEKYGDTDSLRTLRSLVQPFILRRLKTDRTIIQDLPEKQEMNVFCGLSAEQANLYQKMVDDSLNEIEESEGIQRHGLILTLLLKLKQICNHPAQFLKEKSLDTNQRSGKLQRLEEMLEEAISEGDRALIFTQFAELGKLLQPYLQEKLGWETIFLYGSTRKQQREEMIDRFQNDPEGPRIFILSLKAGGTGLNLTRANHVFHFDRWWNPAVENQATDRVFRIGQKRNVQVHKFICNGTLEEKINDIIESKKQLAEQTVDAGESWLTKMDTNQLRNLLMLDRSAIIDEE
>NC_019753.1|WP_015202404.1|1576963_1577833_+|zinc-finger-SWIM-domain-containing-protein
MYTTNNPQNSTNISSREWWAQQWIDLLETSRFKKRLERARNYARQGNVLNIDFEGGKVLARVQGTDPEPYKLTISLDLFDDEQWGYIIETLSQKAFFSAQLLAGIMPQNIQEVFSANGLSLFPFTLPEVHSQCSCPDKEVPCKHIGAVYYLLGDRFSEDPFVLFQLRGRTKEQILETLRQLRRAHVSLPADAEDTKITNTQLQQPKQQPTPLKLNQFWQYNQPLESSLVVITPAANSENILDILGTIPLASDATANPGSNMSQLVNQYLNSIYQTVSQQAVVSALNREE
>NC_019753.1|WP_015202405.1|1577973_1578309_+|hypothetical-protein
MNLVQVLKYCRIIPIALVGMIDVASAAPLTANQAAQYAQPIFAKGFNNVGLGPTTKPNEVAVLCRRVPKQVNTFSCSGRRLDKYCSGTMTVYKTAQNKYKHKNDNFGCVAS
>NC_019753.1|WP_015202406.1|1578428_1579157_-|DnaJ-domain-containing-protein
MDELNKYYQVLGLSPGASLEEVNQAYKDLAFIWHPDRIPTDNPRLQQKAQDKLKEINHARDQLRLIGKNPPTPKAQPRPSSQPTPSYYKQPPTPSYYKQPPTPSYYKQPPTASQYQERKPASDLSGTNMSGADLKEKDFSGRNLSDANLSHANLSDAFLHKVNLQGANLYKANLFRANLLQANLSNACLREANLIGADLSGADLRGADLTGAKIGFNDKIMVKLTGAILAGAIFPDGTIYPG
>NC_019753.1|WP_041225968.1|1579200_1579518_-|hypothetical-protein
MKHFCEHWIQEWCEENGWTDLVIDSGNYWAFPPGAVMPEPIPPRALKLIKANKGFCFEEKLCVAAALVVSFSGSICAYVIKSPIPLVLAFSFTALMVPLLEVEEV
>NC_019753.1|WP_015202408.1|1580033_1580219_-|proto-chlorophyllide-reductase-57-kD-subunit
MRDADLTGILEWTPEAKVKLKNIPFFVRAQARQRVEQLARATGQQMVTGELVEQARLEFGQ

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Crispr_ID: NC_019753_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_10

1991876-1992057

TypeI-A,TypeV-U4?

Consensus_repeat	Method
GGTGGTAAGTATTGCGGTTGGGTTGTAGGTTG	CRISPRCasFinder

2 spacers

c2c9_V-U4

The CRISPR arrays of NC_019753_10

>merge|NC_019753|10|1991876-1992057|CRISPRCasFinder
GGTGGTAAGTATTGCGGTTGGGTTGTAGGTTGTAGTGAATTACTTGGTGTGTTACCTGCCGATGGCGTAGCGGTAGGTGGTAAGTGTTGCGGTTGGGTTGTAGGTTGAGGAGTACTACCAGGCGCATTACCGCTTGCTGGTGTTCCTGATGGTGGTAAGTATTGCGGTTGTGTCGGTGCATT

>NC_019753|10|9|1991876-1992057|CRISPRCasFinder
GGTGGTAAGTATTGCGGTTGGGTTGTAGGTTG	TAGTGAATTACTTGGTGTGTTACCTGCCGATGGCGTAGCGGTA
GGTGGTAAGTGTTGCGGTTGGGTTGTAGGTTG	AGGAGTACTACCAGGCGCATTACCGCTTGCTGGTGTTCCTGAT
GGTGGTAAGTATTGCGGTTGTGTCGGTGCATT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015202758.1\|1999432_2000713_+\|transposase	c2c9_V-U4	-	gnl\|CDD\|223747
NC_019753.1\|WP_015202740.1\|1983302_1983821_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202745.1\|1987768_1988533_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015201199.1\|1993418_1994627_+\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	c2c9_V-U4	-	gnl\|CDD\|223747
NC_019753.1\|WP_015202748.1\|1989267_1989612_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202753.1\|1996066_1996420_+\|YtxH-domain-containing-protein	unknown	unknown	gnl\|CDD\|227313
NC_019753.1\|WP_041225996.1\|1998293_1998923_+\|precorrin-8X-methylmutase	unknown	unknown	gnl\|CDD\|180325
NC_019753.1\|WP_015201200.1\|1992832_1993435_+\|IS607-family-transposase	unknown	unknown	gnl\|CDD\|239738
NC_019753.1\|WP_015202746.1\|1988529_1988865_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_157462296.1\|1987529_1987697_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202752.1\|1995634_1995964_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202751.1\|1995155_1995395_-\|KGK-family-protein	unknown	unknown	gnl\|CDD\|370166
NC_019753.1\|WP_015202741.1\|1983873_1984185_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202755.1\|1997327_1998131_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224429
NC_019753.1\|WP_015202759.1\|2000779_2001481_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202757.1\|1998993_1999404_-\|IS200/IS605-family-transposase	unknown	unknown	gnl\|CDD\|376616
NC_019753.1\|WP_157462295.1\|1984168_1986439_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|236093
NC_019753.1\|WP_015202743.1\|1986549_1987518_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202747.1\|1988864_1989221_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015202749.1\|1989732_1990545_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015202755.1\|1997327_1998131_+\|hypothetical-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	3.07678e-06
NC_019753.1\|WP_015202751.1\|1995155_1995395_-\|KGK-family-protein	gnl\|CDD\|370166	pfam08872, KGK, KGK domain. This presumed domain is found in one or two copies in cyanobacterial proteins. It is named after a short sequence motif.	6.61682e-06
NC_019753.1\|WP_015201199.1\|1993418_1994627_+\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.9035e-52
NC_019753.1\|WP_015202757.1\|1998993_1999404_-\|IS200/IS605-family-transposase	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	5.2037e-53
NC_019753.1\|WP_157462295.1\|1984168_1986439_+\|AAA-family-ATPase	gnl\|CDD\|236093	PRK07773, PRK07773, replicative DNA helicase; Validated.	9.02571e-48
NC_019753.1\|WP_015202758.1\|1999432_2000713_+\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.2229e-22
NC_019753.1\|WP_015202753.1\|1996066_1996420_+\|YtxH-domain-containing-protein	gnl\|CDD\|227313	COG4980, GvpP, Gas vesicle protein [General function prediction only].	9.93537e-24
NC_019753.1\|WP_041225996.1\|1998293_1998923_+\|precorrin-8X-methylmutase	gnl\|CDD\|180325	PRK05953, PRK05953, Precorrin-8X methylmutase.	6.32645e-139
NC_019753.1\|WP_015201200.1\|1992832_1993435_+\|IS607-family-transposase	gnl\|CDD\|239738	cd03769, SR_IS607_transposase_like, Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.	6.72337e-65

>NC_019753.1|WP_015202749.1|1989732_1990545_-|hypothetical-protein
MAPSRQWNFLKTWLRKVYNKEVHEYFKDLSPLDDPDINSGRSATKAACLIAAVDSQNMALLKMNNFYYVVQKSHLKPAIFGQTISSYQESTVPYKPQVLLYFKQDGASVPNDKEPVTAEISFRLVKETHKTIEPIEAKRLATKIKNIFTLADGYKFSKGKIICTYKDIENGYQIRLYVPSDTEAVEVIKKVLSIQDHAYNDDFFTSHIPKKDTINNPGKETVYGRLVSKRRWRPTAIVRFQYATLDIYGLDQPIVLVDRSGTYWGALERT
>NC_019753.1|WP_015202748.1|1989267_1989612_-|hypothetical-protein
MAVAKKLHKVDIGGVNFSVLLPDRYDGIATEVGITEVLPADNIKSHSKISDLINNGQVARIRIRYGVAGVVAAKTANIICDIGKFQTALGDLVGKPYNGGTIRTAYIPQRRRLG
>NC_019753.1|WP_015202747.1|1988864_1989221_-|hypothetical-protein
MAALTKHRVTVGGTTAGGGRIYHFLARKQTFLGLASETGVDEAPLADRDEPVFKLSNLLLKGILVRVNAYYTESGKKRVAKLLVRTDLLKAALGDLPGKSVNGGVIQSCNVPTRSSVF
>NC_019753.1|WP_015202746.1|1988529_1988865_-|hypothetical-protein
MTRIDQGNWSVIHDQLHFVQPNQAVSVVLNFPTDKLIVTLNNLTVAANWIKAGSVEQEWNRLLVPVLLMRKTLSLSTPTLVYLEPVATSTLRFKTVNWLTDIGITIEAFTP
>NC_019753.1|WP_015202745.1|1987768_1988533_-|hypothetical-protein
MKFNKSKTAAFFVGSLIGILIPFLPVIINAENSEKTPEQKEGRRDYLAIGVNAGTIITCALGIAGTIWTVSKKNTEAEFKVKQDLSEKLNGLEKALDEKVKKITDISFAKNEENLQRDLNTKSQAATSVAELKMLFLTTTNNTELAIAELRRDLEKSISVNFGEIVKVHNNLNSSIFEIEAHMETQDKIHKEMSDKLTLTNELAEQRHINGKGEMQLLLRAFHYRLADIEKTLETKHGFSPRRDPINYDIESLG
>NC_019753.1|WP_157462296.1|1987529_1987697_-|hypothetical-protein
MLKDKLDPNDKGLYLAFAGNIIGIWMSTPGTNRPQSVGQLNIDSKIESQIDGNKQ
>NC_019753.1|WP_015202743.1|1986549_1987518_-|hypothetical-protein
MSSLDFNNLKISIYAGINDIPREPTAQLEGNGSHLIAKLNGLIDRIVVELNGYATAQQFAEISDSVTALNGLIGQINNQFSGYATAEQLATINDSVEVIDNSVNQIAAESNGYATTEQLATANARIAALEIDVASLLANSSSNNNSEINLAYSFNGDQNDVFYHLATNGKSTPWDNPHDSGKVTLSTAKAFYLQNTSVANLVDRSTSQDILIGYNQGFPTFINADLKTVKLKLNYYSIQLGWANQQPRNWKIEGSNNNVNWDVLRTHTNDATLNTKGDWASYSITTDTYYRYFRLHQFGGTAGGYDGFTIGEWALYGSLINI
>NC_019753.1|WP_157462295.1|1984168_1986439_+|AAA-family-ATPase
MMFAYKNLSEKELNFVAANRLLPPQNVEIEEGILGGILLDPEAIDRVTDILVPEAFYVPAHQHIYKAALELNNQGKPKDLINVSAWLKEAGLLETVGGLNKLVQLVERTVSAVNVDALAVKVIEHYVQRNLIHLGNRIQSLGYESNAPLTDVLAQVEEETLRLTSLRDKANISYQKAQSQIELEILTRDIERVEKLESPFMKKLETKNLMKKWGLKSEKEFLDLHARWLEASNKKRSYSLDEYLQMHGGKSVNWLLDGWIPEKSITVIHSLGGTGKTTLINTLAKSLITGTDWSKYEVSRPVKILWVQTDQGPTVTNLLLDRQGFFALSSTEKDRQRILDDWYVEEYAVLERELDEHQYDLVIIDSLTSVSSNLIFRENDQEFARPLARLRHIANKKNCAFLILHHSGKGGDMRGTTAIYNAADQVWKMERVLSSDKTAANLTIEKSRFREDKKIYRLNFDTEDSVWIAEGQVVGSGESETIEETVSPALKSILQFLKTHQGVGFEREELSHRLSINDNSCKRLLGDGVRQGLINSFKGARQRAVYYLGQLNLDQPDQPDQSGSEFSDPLETVDIQAVEPCYEAPDQPDQQNTINVSDQPQKTSDPSDPSDPSDPPDPPDPEDEETPALKKGDRVIDLHSKKLGFVKNVERRHHKGTFKKDADYITTKVAVDYGNYTDLTDADLLRLAAPYLYKYLKPGKTLQALKHEDHKGFIRKKGSVVGTIRNLAEKNGKYYATVETDNGLEQYNLEAVEVLD
>NC_019753.1|WP_015202741.1|1983873_1984185_+|hypothetical-protein
MKLKTDDFQIVIKDFIGGQVSDILKSFLSSCHFGVYTNEETKDKCWCILAPSFEVAEALDSLTSWRGYTLLAKLKISKICIYYNSGTEFPELSGVWEVHDVCI
>NC_019753.1|WP_015202740.1|1983302_1983821_+|hypothetical-protein
MKITTIGYGTTRNIGNYENCKVYLEAEVNEGENVDEVLSALRHQADAYAHQHKEVQRLETKKNRLSDDIETYMRKIRSANTAFKRLRQQWEKTTAFLEHHGIKIVDEFPHNPSLYLMTEKLLGETDTENTEKGGEVLDDIPFNDEPDNESDEPDIDPERLAAYEDMLLHGRQ
>NC_019753.1|WP_015201200.1|1992832_1993435_+|IS607-family-transposase
MSKLTISEAAKLKGVAVSTLRRWEAEGKLIPERTANGHRRYDLAQLLGITADSSITVGYARVSSHEQKPDLERQKQVLELFCATHGWQYQIIDDLGSGLNYSKRGLQRLIRMITDNQVERLVLTHKDRLLRFGSELIFSLCEHFGTEVVIINRTEDASFEEDLAKDVLEIITVFSARLYGSRSHKNKKIVEDLREVAEKL
>NC_019753.1|WP_015201199.1|1993418_1994627_+|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MLKSFKTKLDLNNKQRTLAAKHAGVSRHAWNWGLDICLKALDNQEKLPTAIDLHKRLVAEVKSVHTWYYEVSKCPPQEALRNLYKAFQHWFKVPGRGKPKFKKKNVKDSFYLEGSIKISGNRIKFPIFGWVKCYEILPTVQPKNVTVTKRAGDWYVSFKYELEQKVTPKRRDKIGVDIGINALATCSDGSVFPNLKAYRKAKRKLAHLQRSVCRKEKGSNNRNKANLKVAKLHRRIANIRQDAIHKLTTWLAKNHGEIKIEDLNVSGMLKNHRLASAIADCGFYEFRRQLEYKSGWYGSTIIKVDRFYPSSQVCSCCNNRQKMPLKTRVFNCGNCGTTLDRDYNASINLERWHESIDYPKTVSSTGIACGGSHQLNGTAVKDSVKQELDIKFIPKQLSLFDE
>NC_019753.1|WP_015202751.1|1995155_1995395_-|KGK-family-protein
MTEIHLTDEDVLSMEPEYSPIGDPTVQVSEIINFIEGQTRTSAWLTDGAPCRVLRASGGGWKSGKVFIRLSFAPDEDNG
>NC_019753.1|WP_015202752.1|1995634_1995964_+|hypothetical-protein
MVTVVVVLNTLIALISLYVALQIRKLRRRLAKIADTLTKAERNTHKVLSKSPKTISKGQRSFHKLNERYQRFEPQLKKVQQVLAILGLLQRLSQTRLSDRKSKIRTKMP
>NC_019753.1|WP_015202753.1|1996066_1996420_+|YtxH-domain-containing-protein
MSKTSPGSFISGVLLGTAIGAITGLLVAPRTGRETRQLLKKSADALPELAEDVSTSVQIQADRLSESALRKWDQTLSRLQEAIAAGVDATKVERQTLKHTKPEVPAESRPSVSDYKL
>NC_019753.1|WP_015202755.1|1997327_1998131_+|hypothetical-protein
MQHRFTQRILVSLLAIFLAFSAWAIAPVAYAYENADLLPDTQTPIIDLAKSLTAIQEEALAKDLEDFEAATGWKLRVLTQFDRTPGRAVKNFWGLDDKSILLVADSRGGNILNFNVGDAVYGLMPRTFWIELQTRFGNLYFVREHGEDQAIIESLESIKTCLRRGGCNVVPGLPREQWILTLVTSILGGVICGFAGQPRKQGQVFAWQWALIFSPLWGILFISFGIAPVITRTTEWLPLFRNFSGFFIGVLVAYLSPMLARSSSSET
>NC_019753.1|WP_041225996.1|1998293_1998923_+|precorrin-8X-methylmutase
MEWHVTDAQSLSIIDREIGNHNFSPAEYEILRRVIYATADFEYKSLIRFSERALHAGAAAMAARSTIVVDVPMVQVGITPNIQNTFSNPVYCSMEAWTRPQKEKTQAAWGIETLAKRYPEAIYVVGQAQTALTAIVELIEADEIRPALVIGTPSGFVEVDVAKARLKDSMIAHITIDGRKGSAVAAAAIVNGLVDLAWEAYGQKTNVIG
>NC_019753.1|WP_015202757.1|1998993_1999404_-|IS200/IS605-family-transposase
MSTDLNSYRHCVYKINLHIVFVTKYRRKVITSEILTRMEEIFSRICLGQKSKLIEFGGESDHVHLLIDISPDVAPSKLVNSLKTVSSRLIRKEFAEHINKFYWKPVFWTGAYCVISAGGAPLEILKSYIQNQDEPE
>NC_019753.1|WP_015202758.1|1999432_2000713_+|transposase
MIATRRTTFRLYPNQAQTAKLFEWRRLHHWLYNQALSDRQLAYKRDRKSVSYYDQQRAVKVIRQVLPEFKELGSHALQATVKRVDFAYNRFFQGLGGYPRFKSLRHYSGWTYPCNSGWKTHTTGVNGYLDISNLGHIQMRGKARNWGNPTTLTIVYRNKKWYASITVACDVQRETGSGLIGLDFGCNVAVMGAVHLGNDEYEELPIDNPRHLKQVQTKIKLANHQKRRKRAPNYNKRIKASKGWRKANGCVSKLVRIAASQRQDFIHQVAAQIVSSNSMVATEKLNFKNMTKKAKKGSKRKAQKTGLNRSILDVGMGMLRSAIEYKVNEAGGIFVEVPTQKVKPSQRCPKCDHVKPKTLSERIHKCENCSYTCDRDFASAQVCAEYLRTALGTSVEKRRSDSSTSTHCGGFKQVSEMKRQKPRPSS
>NC_019753.1|WP_015202759.1|2000779_2001481_-|hypothetical-protein
MLIPLTRQKFEQLIPILATGPQYAYYWGKFPVFLRRLLISVVAVCIVVFILGKFILGEGLLTFFLGVIAGLYWLWAPVYWASLRNIACRKLPYSGFWRGEVIDLFITEELIGEEQTVNNRGQLVIIENRERRLNIEVGDETGFSTQLQVPLKRTHKAIAPGQMAEMIVMSNRPDLSSITKVSDIYIPNQDLWVSDYPYLRKDAFADVSRQLEYGDDPEYPRKRSTKSRRRRSY

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Crispr_ID: NC_019753_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_11

2133176-2133283

TypeV-U4

Consensus_repeat	Method
GGCGGAGTACTAGCAACGGGCGCGGTAAAT	CRISPRCasFinder

1 spacers

c2c9_V-U4

The CRISPR arrays of NC_019753_11

>merge|NC_019753|11|2133176-2133283|CRISPRCasFinder
GGCGGAGTACTAGCAACGGGCGCGGTAAATCCTTCAGTTGTACTGTTGGGTGTGGTTTGCGGTGCTGTTGCTACTACGGGCGGAGTACTAGCAACAGGCGCGGTAAAT

>NC_019753|11|10|2133176-2133283|CRISPRCasFinder
GGCGGAGTACTAGCAACGGGCGCGGTAAAT	CCTTCAGTTGTACTGTTGGGTGTGGTTTGCGGTGCTGTTGCTACTACG
GGCGGAGTACTAGCAACAGGCGCGGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015202876.1\|2137878_2139321_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236138
NC_019753.1\|WP_015202866.1\|2116921_2117362_-\|IS200/IS605-family-transposase	unknown	unknown	gnl\|CDD\|224854
NC_019753.1\|WP_015202868.1\|2118790_2120947_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|223715
NC_019753.1\|WP_015202880.1\|2143201_2143561_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_083890027.1\|2144455_2145916_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373965
NC_019753.1\|WP_015202870.1\|2127675_2128092_-\|anti-sigma-regulatory-factor	unknown	unknown	gnl\|CDD\|225083
NC_019753.1\|WP_015202881.1\|2143663_2144455_+\|YdcF-family-protein	unknown	unknown	gnl\|CDD\|99750
NC_019753.1\|WP_015202884.1\|2146599_2148780_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274009
NC_019753.1\|WP_015202873.1\|2129928_2131920_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|274400
NC_019753.1\|WP_015202883.1\|2145876_2146596_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NC_019753.1\|WP_015202871.1\|2128191_2129343_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|225118
NC_019753.1\|WP_015202865.1\|2116271_2116841_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_051035443.1\|2115248_2116319_-\|glycerol-acyltransferase	unknown	unknown	gnl\|CDD\|153249
NC_019753.1\|WP_015202879.1\|2141577_2143122_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|225098
NC_019753.1\|WP_015202875.1\|2136192_2137620_-\|DUF3131-domain-containing-protein	unknown	unknown	gnl\|CDD\|371471
NC_019753.1\|WP_041226512.1\|2139562_2140903_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NC_019753.1\|WP_015202869.1\|2121474_2121783_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|240845
NC_019753.1\|WP_015202867.1\|2117412_2118627_+\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	c2c9_V-U4	-	gnl\|CDD\|223747
NC_019753.1\|WP_015202872.1\|2129473_2129800_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_019753.1\|WP_015202878.1\|2140989_2141331_+\|50S-ribosomal-protein-L25	unknown	unknown	gnl\|CDD\|180318

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015202876.1\|2137878_2139321_-\|hypothetical-protein	gnl\|CDD\|236138	PRK07994, PRK07994, DNA polymerase III subunits gamma and tau; Validated.	3.45086e-05
NC_019753.1\|WP_015202866.1\|2116921_2117362_-\|IS200/IS605-family-transposase	gnl\|CDD\|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.27938e-45
NC_019753.1\|WP_015202868.1\|2118790_2120947_-\|PAS-domain-S-box-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.11006e-50
NC_019753.1\|WP_083890027.1\|2144455_2145916_-\|hypothetical-protein	gnl\|CDD\|373965	pfam15611, EH_Signature, EH_Signature domain. This domain with a strongly conserved glutamate at the N-terminus and a histidine at the C-terminus, is found in a SWI2/SNF2 four gene operon. Its strict-neighborhood association with SWI2/SNF2 ATPase strongly suggests a function in conjunction with it. The other genes in the operon are a OmpA protein and a TM protein. This has a DNA related function along with the TerY-P triad.	6.38308e-15
NC_019753.1\|WP_015202870.1\|2127675_2128092_-\|anti-sigma-regulatory-factor	gnl\|CDD\|225083	COG2172, RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms].	5.43047e-25
NC_019753.1\|WP_015202881.1\|2143663_2144455_+\|YdcF-family-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	5.17717e-42
NC_019753.1\|WP_015202884.1\|2146599_2148780_-\|hypothetical-protein	gnl\|CDD\|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.000476515
NC_019753.1\|WP_015202873.1\|2129928_2131920_-\|glycosyltransferase	gnl\|CDD\|274400	TIGR03030, Cellulose_synthase_UDP-forming, cellulose synthase catalytic subunit (UDP-forming). Cellulose synthase catalyzes the beta-1,4 polymerization of glucose residues in the formation of cellulose. In bacteria, the substrate is UDP-glucose. The synthase consists of two subunits (or domains in the frequent cases where it is encoded as a single polypeptide), the catalytic domain modelled here and the regulatory domain (pfam03170). The regulatory domain binds the allosteric activator cyclic di-GMP. The protein is membrane-associated and probably assembles into multimers such that the individual cellulose strands can self-assemble into multi-strand fibrils.	1.44343e-73
NC_019753.1\|WP_015202883.1\|2145876_2146596_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	6.49859e-18
NC_019753.1\|WP_015202871.1\|2128191_2129343_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|225118	COG2208, RsbU, Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription].	1.85889e-52
NC_019753.1\|WP_051035443.1\|2115248_2116319_-\|glycerol-acyltransferase	gnl\|CDD\|153249	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.	7.91253e-25
NC_019753.1\|WP_015202879.1\|2141577_2143122_+\|AAA-family-ATPase	gnl\|CDD\|225098	COG2187, COG2187, Uncharacterized protein conserved in bacteria [Function unknown].	2.06496e-167
NC_019753.1\|WP_015202875.1\|2136192_2137620_-\|DUF3131-domain-containing-protein	gnl\|CDD\|371471	pfam11329, DUF3131, Protein of unknown function (DUF3131). This bacterial family of proteins has no known function.	0
NC_019753.1\|WP_041226512.1\|2139562_2140903_+\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NC_019753.1\|WP_015202869.1\|2121474_2121783_+\|RNA-binding-protein	gnl\|CDD\|240845	cd12399, RRM_HP0827_like, RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins. This subfamily corresponds to the RRM of H. pylori HP0827, a putative ssDNA-binding protein 12rnp2 precursor, containing one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). The ssDNA binding may be important in activation of HP0827. .	1.00591e-32
NC_019753.1\|WP_015202867.1\|2117412_2118627_+\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.76434e-59
NC_019753.1\|WP_015202872.1\|2129473_2129800_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.55701e-26
NC_019753.1\|WP_015202878.1\|2140989_2141331_+\|50S-ribosomal-protein-L25	gnl\|CDD\|180318	PRK05943, PRK05943, 50S ribosomal protein L25; Reviewed.	9.07942e-32

>NC_019753.1|WP_015202873.1|2129928_2131920_-|glycosyltransferase
MTRSYFADRPQSFPGNSRSSLKKRTLLFRYLAEINLILGAWYLYWRINNSINFDALWLAIPLLLAEIYSYIGGLMFTIGLWRPLVREIKSLDQLTPPIPPSKWPTVDIFITCYSEPPEMVEETARAGLAMDYPASKLRVYILDDGNSAEMRAMAQRLAIEDLQSPLLQEEAHRIEAERNYLVSRLEQLEELTPEIELSEQVLQDFSSKGAEVFDPQAIGILERLRQFILWLQPHHATINDCINTDRQQLEQAIHEKDLQLSDLARCRYFARPKPAGVTHHAKAGNINYAMFSGETSGEFVVTLDADHIPRPQFLKRVLPYFYNYNVFNGQYESNKIAFVQTPQDFYNLPLGDPFGHSANLFYGPIQQGKDGMNSAFYTGTNAILRREAVVSVGLQYFADEYSKDEKRLDEFELVGGVSSNSITEDMNTAMRLHGAGWKSVYHNEILAQGLAPDDLSSTIKQRLRWAQGTIQVLQRENPLTKPGLSFWQRLQYFQTMYSYFSGFFVFILIACPILFFFTGVIPVKAYGYDFALHFFPAFIVNRLTFLAATWGIPAREVWRSEQYAVAFFPLFIQAVVSVFTGKPIKFQVTPKQRQAGVYFELVKPQLIIFALTILGILWSLYRFITGSLDQPLVHLFNTGWSIYNLALLWAVIKAARWQPKEFS
>NC_019753.1|WP_015202872.1|2129473_2129800_-|STAS-domain-containing-protein
MSSEVKVVEPTGILDGIRGNKLRQEISDHVEKGAKIVLIDLKNVTFMDSSGLSALVSALKTVRTGGGKLYLSSINDQVKMVFDLTRMDRVFETFASVDDFNQAMSKES
>NC_019753.1|WP_015202871.1|2128191_2129343_+|SpoIIE-family-protein-phosphatase
MFKILIIDDDPTLRMILKRTIVNQGYEAIVASNGEQGIKFAKEQRPALIICDWMMAPVDGLEVCRTVKADQELSSTFFVLLTAKGEVEDRVMGLDAGADEFLSKPLDMNELKARVRAGLRLYLLNEDLLTQKRELQELNQKLRTELDEAAEYVRSLLPQPLKQPIATEALFKPSAELGGDCFDFYKLDDEHLAIYLLDVSGHGVGSALLSVSVLNVMRSQSLPNTNFAKPSDVLKSLNQVFEMTTDKYFTIWYGVYNHVTRELVYATGGHPPAILLLPGTSDSEIEVKQLGIPALPIGILPDEDFEEQSCQITSNSTLYIFSDGAYEINLPNGKLWGLDALSELLQYFQKNHLHLNHLLDHIKIATSDGAFDDDLSILKVNFI
>NC_019753.1|WP_015202870.1|2127675_2128092_-|anti-sigma-regulatory-factor
MLQKISLRVNSDLNDSEKVLSWFEQLNQPPLPKPEAWWQCLTLLQEGFANIAQHAHKQFPPETPVDIEATRFNDAIEIRIWSYGPPFDLNQSLKEIPELEDNSGERGRGLKMMSIMADYLSYEKTSDERRCLIIRKNY
>NC_019753.1|WP_015202869.1|2121474_2121783_+|RNA-binding-protein
MSIYVGNLSYQVTEEDLTEVFAEYGTVKRVQLPTDRETGRMRGFGFVEMSTDDEETAAIDALDGAEWMGRDLKVNKAKPRTEGGGGGNFRRGGNFSGSRERY
>NC_019753.1|WP_015202868.1|2118790_2120947_-|PAS-domain-S-box-protein
MKFKAGTKGISMLNIKRSQVQGYGVAVLTVAIAIFLKLMLKPWVALEDSPFLVFFVPIMVSAWYGGIGSALLATALGGVVGYLWTPPSSAWSSNSVGDSLRLVIFLLEALCISYFITALQLAQRRSELNKVQAQQNLESLRHSEEGFRLLIDCIKDYAIYRLDPQGYIVSWNEGAERINGYQIGEVIGQHFSRFYTEEELNSGKREQVLKLAAETGRFEDEGWRVRKDGSRFWANVVITALRDQAGNLKGFAKVTRDVTESKRLEAERNQLLVREQASRALAETANEMVQRLQAITDVAIAPLSLEDLLRELLNRISEILRADTAAILMMDYQHNCLVVKAAKGLEEAGGEVCIPIGEGFAGRIALEHQPLIIQQDAYTQVYNAVLSQQQVQSLLGVPLLLDNRLIGVIRVGTLLPRQFNQDDVQLLQLVAERAALAIDRARLNEAERAALTQAQEANRLKDEFLAIVSHELRTPMQSILGWSQMLRKGELKPETVTKALETLERNAKQQARVIDDILDVSRIIRKKISIRLIPLNIAPIIKSAIISISPAAAAKNIQITSTINSSISQILGDPDRLPQIINNLLSNAIKFTPQCGSVEIKLEQMEFNVILTVIDTGQGIEPEVLPYIFDDFRQGDSSRTRTHGGLGLGLTIVRYLVDLHGGTVQADSEGEGKGAKFIVKFPIHQPKLSNEGKGISGEINSSDITSQATKKKARPKYI
>NC_019753.1|WP_015202867.1|2117412_2118627_+|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MKSRYQYRIYPTNQQKKHLAQLFGCVRVVFNDALAYCQEKYKKGEKKPNNTELSRRLTELKKTEEKIWLGEVSSIPLQQSLRDLDQAYQNFFNSCKGERKGKKIRPPKFKKRKSKQSAKFTNNGFKINHDTVYLPKIGDLDIVWSRPLPSESSSLTVIKDAADRYFLSFVVEIIPEILPDNGKSIGIDLGIIDFATFSNGEKIKAPKPLKKKLKKLNRLQRRFSQTIKGSKRREVARKKIARLHAKISDTRKDFLHKLSTKVIRENQTIALEDLNVSGMVRNRKLSRAISDLGWRSFRTMIEAKGEKHGRDLRIINRWEATSQKCSCCGQKGGKKELSVREWTCLFCDTKHDRDVNASVNILNVAVGHIETKNGRRRKCQTGVKSAVSSDASTHLEPIQLSLFG
>NC_019753.1|WP_015202866.1|2116921_2117362_-|IS200/IS605-family-transposase
MSSNLRHERHSISDLKIHLVCVAKYRRQIFTIESLNLIEKSFREVALKMNFKVLEFNGESDHIHVLLEYPPKLSISQIVNAVKGVSSRRYGQAGFEKPYGKDALWSPSYFVSSVGGAPLEILKSYIQNQEKPSSTTLKDGVLNPIL
>NC_019753.1|WP_015202865.1|2116271_2116841_+|hypothetical-protein
MNTPSHAIINLAILGQFYRPQSNLAIVFGAILADIPIFIFYLWSRFIERIPAEEIWSKAYYQPFWQNIIATFHSIPLAVIGIIIAHYLGWEPMKVIFISLVLHSLGDLPVHNDDAHRHFFPFSNYRFISPISYWDVTKHSRIVSLVERLLVLASTIYAFPLVHSYIGKGLMIVVNVFYFITSLYFYAIK
>NC_019753.1|WP_051035443.1|2115248_2116319_-|glycerol-acyltransferase
MTENCKINNGVAGSIHNFKFSWFDWFCLWYPPGWLILFNRHWQKYHQDPDGWNWLEYGLFLIPLGFYLALLLRWLRLGCRSPRSEVGEFAPNYQQAFRDEVLTPIVKYYFRADLAGLDNLPQTGPLIVAMNHAGMCFPWDFLGLGYLLSQTRGWVVQPLAHVTLFNHPWLIWWLPPGWSKVLGGIPAQADSFEEAIAQQTILLYAPEGLRGPAKGWRKRYKLETFHPSFIRLSDRYHIPILPVVCIGNETLHSWAFNFKSGARRLKLPFLPISLLMIAFVFFPSMGVWAMKTRLQYEVQPVYQPWLQTNSAISEQAVQTSADTEGSAIYQQAQSLRAKLQIKINQLISFMDNLSTN
>NC_019753.1|WP_015202875.1|2136192_2137620_-|DUF3131-domain-containing-protein
MNSDFEPPPKSWSALATVGGILTALAAIAVLQSVSNNLNKAQRTEKKAGTQTVASTFEKQDLKSIKLSGIPVPFNEIVATKPYVAPSTGKLTAAELEMARQAWSYFEKNWNEETGLVNSVDGFISVTLWDQAAAMAALVSAFELEIVPETEFNEKMATTLKSLAKLPLYKKELPNKVYNPKTLIPVNYGKVDQQEEIGWSAIDLGRMAIWLKIVAAKYPQFRSDARAVWRSWDVDRLVKNGQMYGTSVVNGEELYNQEGRQGYENYAAYGLKLLGLNVDRALNPTNYLGFVNLYNKGVPYDLRDAKTSGANNYVLSEPFILDGIEIGFQGLPKAFADRVLAAQQSRYEATNQLTAVTEDNLDREPYFVYSSLFVNGEPWAVITDTGKKYNNLRFISAKASVGWHVLYNTPYTQKLFDFVQTNLKSEKGWYNGYYETLREPNKSLTANNNGVIMESLLYKQVGKPLIVWAGVESSE
>NC_019753.1|WP_015202876.1|2137878_2139321_-|hypothetical-protein
MANLITPDRSVASTNHYAKLLLICLQPRWGVCWSVFFLLLNGTALKAATNNDIAPIPQNFISPSELISHKQQIAEIQDIFLQPNSNIQSNSPQLYYQIKPQILIAAPDNFTPRLRSQEVPLNLIAAPDNLVPNQQVQPPAQSAPTPSPAPPAQLAPTPASTPTPTTPPLPTVQPPASLPEANPSATIQNAVLPSFSLDNLQINFRNDVDKFGRENRFIEPTAQFRLSNGNIVQLKTGFNYFKYPGLEDVSNIPLTLGYQTKINQVTLQAGVGVDVFNRLPTAINFNTKVDVPVGNNITLSGVVEQGLYKFNAETLENQIRTWRYGPNLYWQIDRNTSLFSLLRLGNYNDGNFEQQSFSRLERKFGPFSIAANLFNWSYNEDYSEKSGYFSPPDFLVFTGEVALESEIFDFLRCRVAASLGQQRLRGEFSNANSYEGRCTGKISQNIDADFGYVFSNVQNQETGNSQYNNQSFTGVLRFKF
>NC_019753.1|WP_041226512.1|2139562_2140903_+|adenylosuccinate-synthase
MANVVVIGAQWGDEGKGKITDLLSKSADVVVRYQGGVNAGHTVVVKGQTFKLHLIPSGILYPDTDCIIGCGTVIDPELLIQELDQLQALKIPTGNLLISQTAHVTMPYHRIIDEASEKQRGNHKIGTTGRGIGPTYADKSERTGIRVQDLMDSDTLRSQLRWTINYKNVILEKLYNLPPLDPEKVIEEYLGYAERLRPYVVDTSLFIYDAIQRRRNILFEGAQGTLLDLDHGTYPYVTSSNPVAGGACVGTGVGPTMIDRVIGVAKAYTTRVGEGPFPTELNGKMGELLCDRGAEFGTTTGRKRRCGWFDALIGRYAVRINGLDCLAITKLDVLDELEEINVCVAYEIDGKLIEEFPSSARQFANCKPIYKTLPGWQQSTTECRSLDDLPKQALDYLKFLAELMEVPIAIVSLGASRDQTIIVEDPIHGPKRALLHANGSPVQSVV
>NC_019753.1|WP_015202878.1|2140989_2141331_+|50S-ribosomal-protein-L25
MPLTIECQKRPEGSKPRALRRSGLLPAVLYGHNGRESISLVMNSKQFGDLLKASSGKKPEVQLTIPELSWSGTTVLQEVQIHPWKKFPYHVSFFATKSETAETAETAETAETV
>NC_019753.1|WP_015202879.1|2141577_2143122_+|AAA-family-ATPase
MTDASLPALIQQMMQPGFYPHPVKEPIALIQTHVSYVLLTGDYVYKLKKQVNFGFLNYSTLELRQHFCHEEIRLNRRTARDLYLEVLPITQEGEQYQLDGTGEAVEYTLKMLQFPQESLLSNLFEQGQLQEKDIEELARIVAKFHAEAKTDEYISKFGEVPQVRAAFDENYQQSEKYIGIAQTQVQFDETQKFTDAFFAEKQDLLNIRITNNFIRECHGDLHLRNICRWQDQIVLFDCIEFNEPFRFADVMYDVAFAVMDLDARGRKDLGNVFLNTYIEQTGDWEGLQVLPLYLSRQAYVRAKVTSFLLDDPAIPQADKDAAAKTAAEYYKLAWEYTQPKQGRLVLMSGLSGAGKSTVARQVARLTEGVHIRSDAVRKHLGGIRLEEKGGSDLYTAEMTQKTYGRLLELGVKLASQGFTVILDAKYDRESLRKDAITLAQSQQVPLQIIYCTAPEEVLRDRLNKRTGDIADATADLLTSQQAATEAFNEEEKGYVRTLDTTTDWQGKLQQLLVG
>NC_019753.1|WP_015202880.1|2143201_2143561_+|hypothetical-protein
MVNQEDNKGQKKDKENDAETTQDSGMSAGISAGLKLWLFFMLSFVLVGNPIPFSIFLGAIGGLSGGLVFAWWNSTDEKLDQAQASQVPTKVSGFRRAKLLRNANAKYPKLSKKRREQNK
>NC_019753.1|WP_015202881.1|2143663_2144455_+|YdcF-family-protein
MFLFLSKLIPLFLYPLGLACLLMLVTLVLMWKRSRWAAFPVVLALTALLLGSNGWVSNWLVRSLEVQNIPQTTLPVADAIVVLGGGTRPAVAPRPTVDLSEGGDRVFYGAQLYREGKAPWVISSGGRVEWRGGGSPESGDMGIILQTLGVPQSAILQDPNSLNTYENAVNVRAILNAYNLNKVLLVTSALHMPRSLAIFKRQKIDAIPAPTDFLVTQQEIQEPDSSNQAFILNLLPDVEKLEKSTKAIKEYIGIFIYRLRGWA
>NC_019753.1|WP_083890027.1|2144455_2145916_-|hypothetical-protein
MVSKNAIASESTMNVRFRQLHLNPSQPPSYQPTELLKLSKGLKTNSYLKNLANIPRLFRTKFRSLTEILSDIQSNQIEQVSVLEWVYCLYHKNTWDAKNPDLRIASSQAIWKAANKNSWLLQKLLWRVVLYYSGQRETAIASSLVDTFPSNIKSNSLAIQIINIIKQPHAAKKLAQLCYTNLLLPQQLLEQSHLPTWIPVATEALNHVAEVFSDPSNINYKHTDWLLRCLNQMSADQQLLAVDSLLNKISPELGANLTQLVTWLEENYSPRVTNSRWNQLSLFAKSALRKWIGAVNYRDFANLIDQLLETLDQNSLDFKQLKSRRKFWADYSDRFQRLRILFPQNSVNILGSYLHGQDVSILIDDGSEPTEVCIFDFGDWFVIEFFRGWSSEIRLIANNPETEAILFGDNLSVKRLRCLGGKRHDHRYLWQFSCEEWLNQNQIPPNSGTKPYPNPTSQQLQDRNHQLIEWNRVIQKLEKEAQEYCF
>NC_019753.1|WP_015202883.1|2145876_2146596_-|OmpA-family-protein
MSNFSQFDVEPEVEEQDDSSFLLSIGDLMSGLLMLFALLFIIVQMQLSERIQEVKRLETELAAYKKAIDELPIRILNAINGNVGGKGVFIVDPKTGDVSIAERLLFDEGSAELKPEGKKFLQEFIPVYSQVIFSNNKFDEQITRIVIEGHTSSEGSDKVNLELSLRRSLSVSDYIFSNQLNFKTKGQLRNKILAAGRGEIDANQKIDNPSDRKVVFRFQFKREDFSKWFPKTRSPVSQP
>NC_019753.1|WP_015202884.1|2146599_2148780_-|hypothetical-protein
MITNLIFIGLTLLIGLFFLGLEIKFTCDYKKYYSQESKDTQDTIKYLNDQLVNQEKIVNGVLELKKFPNWNWIKEHLEGNYRIQDGVFNAQIKDSRFVLKKYPAALTWSIPRSYFKFIPGILTAIGILGTFWGIQIGLQNINLNSTENFSQLLPSIQQLLDGMRTAFLTSLFGLGSASVFTLILAGSEWARTKTRNDLRKKLDKIAWLKTDADLESNQLTAEAIGKATGTQVRDKIAPLINPIKEELREIRAIQAAQNQLTPQEISQQVALAFAPLINPISEHLREIRSTQFAQKQLTSEAIGQQVALALAPGFTEIRNDLLAQRQTIEQQRQELLTTLIQELRTEVVEPVVLRLDESARLTREASQAVRELKDALGEITQSLAESIQTIQRFQENTLGQLQQFAVDLRQILSQFQTETQGVLQQVATEIQRAVSTSIEGLATQRQAFIASARQAATFFQGIQENLQEALKTQAQQQKEMLAGVESQTINILAEANQAFLTQSRTIETVGVQASSVMDTARTNLEATLNNIDENLQNTRNTVQQELENFRINYQSALVTFFNEQNNLLNDTLGQQRDGLAGVVADLQRVFVEEAEQRKELAAQVNDSMARINGTVQRVSELANVVGLSSSERLAQLIELSRTISGEAQRVERAYQNMGNQFNQALDNWNQQIITYLDQATNSQTTFFNQADNSMAKVCNGLNETANGLLDVSQYLVSAANEARMRK

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Crispr_ID: NC_019753_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_12

2914018-2914126

TypeV-U5

V-U5

Consensus_repeat	Method
GTTTCAACTACCATCCCAACTAGGGGTGGGTTGAAAG	CRISPRCasFinder

1 spacers

c2c5_V-U5

The CRISPR arrays of NC_019753_12

>merge|NC_019753|12|2914018-2914126|CRISPRCasFinder
GTTTCAACTACCATCCCAACTAGGGGTGGGTTGAAAGCTAGATGCCCAGTCGCCATTTAATTTGAAGCCTGGGTTTCAACTACCATCCCAACTAGGGGTGGGTTGAAAG

>NC_019753|12|11|2914018-2914126|CRISPRCasFinder
GTTTCAACTACCATCCCAACTAGGGGTGGGTTGAAAG	CTAGATGCCCAGTCGCCATTTAATTTGAAGCCTGG
GTTTCAACTACCATCCCAACTAGGGGTGGGTTGAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015203571.1\|2920294_2921617_-\|peptidase-S13	unknown	unknown	gnl\|CDD\|224938
NC_019753.1\|WP_015203564.1\|2911148_2911589_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133380
NC_019753.1\|WP_015203574.1\|2924067_2924967_+\|ACP-S-malonyltransferase	unknown	unknown	gnl\|CDD\|272922
NC_019753.1\|WP_015203559.1\|2903833_2904259_-\|restriction-modification-system-DNA-specificity-domain-containing-protein	unknown	unknown	gnl\|CDD\|341138
NC_019753.1\|WP_015203562.1\|2908111_2908708_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_041226634.1\|2922827_2923838_+\|ketoacyl-ACP-synthase-III	unknown	unknown	gnl\|CDD\|236475
NC_019753.1\|WP_041226037.1\|2902506_2902854_-\|STAS-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379507
NC_019753.1\|WP_015203567.1\|2915424_2916147_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NC_019753.1\|WP_157462432.1\|2919090_2920281_+\|LPS-export-ABC-transporter-periplasmic-protein-LptC	unknown	unknown	gnl\|CDD\|275202
NC_019753.1\|WP_041226040.1\|2918162_2918768_+\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350235
NC_019753.1\|WP_015203556.1\|2901901_2902507_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015203572.1\|2921787_2922822_+\|phosphate-acyltransferase-PlsX	unknown	unknown	gnl\|CDD\|235414
NC_019753.1\|WP_041226039.1\|2905540_2906683_-\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NC_019753.1\|WP_015203563.1\|2908751_2911142_-\|type-I-site-specific-deoxyribonuclease	unknown	unknown	gnl\|CDD\|226581
NC_019753.1\|WP_015203566.1\|2914501_2915332_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_019753.1\|WP_015203558.1\|2902870_2903746_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|214643
NC_019753.1\|WP_015203575.1\|2924953_2925607_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NC_019753.1\|WP_015203560.1\|2904219_2904942_-\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341131
NC_019753.1\|WP_015203565.1\|2911657_2913502_+\|hypothetical-protein	c2c5_V-U5	-	unknown
NC_019753.1\|WP_015203568.1\|2916470_2918063_+\|methionine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237012

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015203564.1\|2911148_2911589_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133380	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators. Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	1.95663e-18
NC_019753.1\|WP_015203574.1\|2924067_2924967_+\|ACP-S-malonyltransferase	gnl\|CDD\|272922	TIGR00128, Malonyl_CoA-acyl_carrier_protein_transacylase, malonyl CoA-acyl carrier protein transacylase. This enzyme of fatty acid biosynthesis transfers the malonyl moeity from coenzyme A to acyl-carrier protein. The seed alignment for this family of proteins contains a single member each from a number of bacterial species but also an additional pair of closely related, uncharacterized proteins from B. subtilis, one of which has a long C-terminal extension. [Fatty acid and phospholipid metabolism, Biosynthesis].	7.77358e-103
NC_019753.1\|WP_015203559.1\|2903833_2904259_-\|restriction-modification-system-DNA-specificity-domain-containing-protein	gnl\|CDD\|341138	cd17249, RMtype1_S_EcoR124I-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.EcoR124I TRD2-CR2, S.Eco540I TRD2-CR2, S.Eco540AI TRD2-CR2, and S.Eco540ANI TRD2-CR2. Escherichia coli (R124) S subunit (S.EcoR124I), E. coli ST540 S subunit (S.Eco540I), E. coli ST540A S subunit (S.Eco540AI), and Escherichia coli ST540AN S subunit (S.Eco540ANI) recognize the sequence 5'... GAANNNNNNRTCG ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, S.EcoR124I -TRD1 recognizes GAA/TTC, and -TRD2 recognizes CGAY/RTCG. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	1.11465e-52
NC_019753.1\|WP_015203575.1\|2924953_2925607_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	1.24023e-49
NC_019753.1\|WP_041226634.1\|2922827_2923838_+\|ketoacyl-ACP-synthase-III	gnl\|CDD\|236475	PRK09352, PRK09352, beta-ketoacyl-ACP synthase 3.	2.72092e-176
NC_019753.1\|WP_041226037.1\|2902506_2902854_-\|STAS-like-domain-containing-protein	gnl\|CDD\|379507	pfam14213, DUF4325, STAS-like domain of unknown function (DUF4325). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 99 and 341 amino acids in length. This domain is distantly related to the STAS domain.	8.18788e-16
NC_019753.1\|WP_015203567.1\|2915424_2916147_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	3.56358e-32
NC_019753.1\|WP_157462432.1\|2919090_2920281_+\|LPS-export-ABC-transporter-periplasmic-protein-LptC	gnl\|CDD\|275202	TIGR04409, LptC_YrbK, LPS export ABC transporter periplasmic protein LptC. Members of this family are LptC, a periplasmic protein tethered to the inner membrane in the lipopolysaccharide (LPS)exporter transenvelope complex (Lpt), which is responsible for conducting LPS to the outer leaflet of the outer membrane in most Gram-negative bacteria. LptC is homologous to LptA, another member of the transenvelope complex. Genes lptC and lptA are often adjacent. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other].	1.6824e-16
NC_019753.1\|WP_041226040.1\|2918162_2918768_+\|NYN-domain-containing-protein	gnl\|CDD\|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.93322e-67
NC_019753.1\|WP_015203572.1\|2921787_2922822_+\|phosphate-acyltransferase-PlsX	gnl\|CDD\|235414	PRK05331, PRK05331, phosphate acyltransferase PlsX.	7.25499e-172
NC_019753.1\|WP_041226039.1\|2905540_2906683_-\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	4.11623e-05
NC_019753.1\|WP_015203563.1\|2908751_2911142_-\|type-I-site-specific-deoxyribonuclease	gnl\|CDD\|226581	COG4096, HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	7.96786e-141
NC_019753.1\|WP_015203566.1\|2914501_2915332_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.11694e-14
NC_019753.1\|WP_015203558.1\|2902870_2903746_-\|ATP-binding-protein	gnl\|CDD\|214643	smart00387, HATPase_c, Histidine kinase-like ATPases. Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.	0.0043362
NC_019753.1\|WP_015203560.1\|2904219_2904942_-\|restriction-endonuclease-subunit-S	gnl\|CDD\|341131	cd16961, RMtype1_S_TRD-CR_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR) and similar domains. The restriction-modification (RM) system S subunit generally consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This superfamily represents a single TRD-CR unit; in addition to type I TRD-CR units, it includes RMtype1_S_TRD-CR_like domains of various putative Helicobacter type II restriction enzymes and methyltransferases, such as Hci611ORFHP and HfeORF12890P, as well as TRD-CR-like sequence-recognition domains of the M subunit of putative type I DNA methyltransferase such as M2.CinURNWORF2828P and M.Mae7806ORF3969P.	4.44259e-15
NC_019753.1\|WP_015203571.1\|2920294_2921617_-\|peptidase-S13	gnl\|CDD\|224938	COG2027, DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane].	4.08418e-54
NC_019753.1\|WP_015203568.1\|2916470_2918063_+\|methionine--tRNA-ligase	gnl\|CDD\|237012	PRK11893, PRK11893, methionyl-tRNA synthetase; Reviewed.	0

>NC_019753.1|WP_015203565.1|2911657_2913502_+|hypothetical-protein
MSQITVQCRLVASESTRHHLWKLMADLNTPLINELLARMAQHQDFETWRKKGKLPDGIVKQLYQPLKTDPRFTNQPGRFYTSAITVVDYIYKSWFKIQQRLEQKLKGQIRWLGMLKSDEELAAESNTSIEVIRTNAAELITSLSSEDGSVSTRLWKTYDETDDILTHCVICYLLKNGSKVPKKPEENLEKFAKRRRKVEIKIERLRRQLESRIPKGRDLTGKNWLETLAIASTTAPADEPEAQSWQDTLLTESKLVPFPVAYETNENLTWSKNEKGRLCVQISGLSKHIFQIYCDQRQLKWFQRFYEDQEIKKANKDQYSSGLFTLRSGRIAWQEGTDKGEPWNIHHLILYCTVDTRLWTAEGTEQVCQEKAEDIAKTLTRMKKKGDLNDRQQAFIRRQQSTLARLNNPYPRPSQPLYQGQPHILVGLAFGLDKPATAAVVDGTTGKAITYRSLKQLLGDNYELLNKQRKRKQQQSHQRHKAQSNGRSNQFGDSDLGEYVDRLLAKALVTLAQSYQAGSIVLPKLGDIRELIQSEIQAKAEQKIPGYIAGQEKYAKQYKISVHQWSYGRLIDNIKAQAAKISIVIEEGQQPIRGSPQEKAKEMAISAYDDRTKS
>NC_019753.1|WP_015203564.1|2911148_2911589_-|MerR-family-transcriptional-regulator
MSETFFSSKETAEITGCSLRQLQYWRERGVVVPPISATGTGRSIYYSRSELAELIVMEYWLSVGLSFEVAAKALQALKQKAPDFSDPVVQKRFMLVWDKEKKDLSLEEFEREDAIASLDKGQPVIPMWLDQIHHQLAVKLDESTVK
>NC_019753.1|WP_015203563.1|2908751_2911142_-|type-I-site-specific-deoxyribonuclease
MSNEANTCRKYVEPRLENAGWNTEPHDYTENYYFTDGKIRPRNQRKPRGKRKFADYLLLYNGEFPLAVVEAKRKRKTPDEGLEQAIDYAKILNVKFAYSTNGKGIVEYDFITGKQSDVINSFPSPEQLWQRLTGEGKEQIREDIAEKLLTPFYPIPDKPPRYYQRNAINAALAAIFKGQKRLLLTLATGTGKTTVAFQICWKLSSIEWNVNSEPRSPRILFLADRNVLVDDPMNKDFSAFNEEKIHKIQGEAKKGRDLYFAIYQAIGDREDSFGLYREYSRDYFDLIIVDECHRGSARDESNWRQILEYFEPAYQLGLTATPLRDDNIDTYHYFGNPLYTYSLKQGIDDGFLAPYRVYRITTRSDREGWRPNSGQIDRYGRTIPNEVYQTPDFERRLVREVRTKAIAQHITDFLKSSDRYAKTIVFCVDEEHVKAMIKELRNLNSDITRTNPDYITRITSDAGEVGKGHLYKFKDVLNETHIIAVTSKLLTTGVDIPTCKNVVLARVIRSMTDFKQIIGRGTRVKEERGKRSFNIIDYTNSTVLFEDRDFDGEPALINESEIDDRGEILSQHEEELEPAELEEETDDLEEDEKSGFRGLPDDDDAPPRKYYADGGSEEIVEERIYDLNPDNQLRLSRLIDYTREQVRTLYRSTLEIQQRWADPEQRSEIIELLADRGIDFDELKQVTNFPDADPFDLLCHIAFDAPVLTCKQRAERLRRSNADFFEQYGEYARAILEILLDKYAEKGVEEFNIPTTFKANREFDKYGNVAEIAQRFGSVQELKEAIKKMQSLLYSA
>NC_019753.1|WP_015203562.1|2908111_2908708_-|hypothetical-protein
MSKNKSNNILFKEKSMRWLIVKLLSFLGIVYLLSILVLAIKPDNRLSITEVAIFLIILLFNSELAEKIEEISFGELKAKFTEVKQEQEKQRADIDTLQFLVNRFVTKEELSHLKNLADDKAEAKYWINDEVRRELRHLRGLGLIESYRGKYIGQLQQQVSIKEYVRITPEGQAYLNMRKSELREDSLKDESMKNDNHE
>NC_019753.1|WP_041226039.1|2905540_2906683_-|IS4-family-transposase
MLPSFYQKYLERYFKPAQLITLKMLVWLLQSHKQVRIERLAANLPLPILENSRRRHIQRFLSLGSLNILALWLPLVREILDRQLKAGTQLIIAIDRTQWRENNVLMVSAIYQKRAFPIFWTLLDKKGACNLAEQKQVLRPVIRLLNKYKLVIVGDREFQSIELAQWLHRQHLSFVLRQKCNTTFREKRQKFQPLSNIPIQPGIRLFYPHISLTQKKGFNRFNLAAYWKRKYKGKQEKEPWYLLTNLPCLNSATNIYKQRYGIEAMFKDCKTGGYNLEDSQTSPDRLIKLILLIALAMTSAWLHGQRIQAKGQQKYICRLTEKGRTRRRHSNFWIGLYGETWLVSFHECQPWVEEMLNLIANKKPFYQRGLRAVNLIDQPL
>NC_019753.1|WP_015203560.1|2904219_2904942_-|restriction-endonuclease-subunit-S
MSKAMYMMPLSKVLTRRKYEIDIQEIDSYTRITIRMNNQGILIRDRVTGSEIGTKKQFIIKAGQLVLSKIDARNGAFGIVPNDCNGAIITGNFWAFDVNHELLDIQYLDYLTKTSLFTDFCIRASDGTTNRLYLQESKFLSMQIPLPPLEEQRRIVARVEELVGKIEEARSLRQQANEETNMLWRAIAKDIFTHLAQTVKEPLRQLITVQGGGTPSKENPFFWQGSIPWVSPKELNQVQC
>NC_019753.1|WP_015203559.1|2903833_2904259_-|restriction-modification-system-DNA-specificity-domain-containing-protein
MGITQGIEPGAVLIVVRGMILAHTVPSAVLRVLAAINQDMKALLPKEDIKPEFLCYVLWAFNDSLLELVEKSTHDTRKLETSKLLNFQIPVPSLAEQDRIVAYLNQLQTKVDTMKRYREDALKELNALLPSILGKAFNGEL
>NC_019753.1|WP_015203558.1|2902870_2903746_-|ATP-binding-protein
MSLIVTVPTINDKAKDFDRLFQLWTQVQENTKEVIFDFSQCFFLRQNAVAFLGGLARLIESRGGKVIFDWDTVKNHVRMNLKQNGFMYAFNSGEEPWQGNSIPYREDRYQDIDGLTHYLAEQWLGKDWVHISDLLRSVIVSTAWEIYANAFEHGRTEIGVFSCGQHYPNLGELKLSVVDFGVGIPQNVRDFQKNPNLPADQALQWAFQKGTTTRGGRVTGGIGLDYLKQFVHINKGKLQILSNDGCATIDKQQEVYEKRPSFFGGTLVNITLLCDESYYALELEPDDEPLF
>NC_019753.1|WP_041226037.1|2902506_2902854_-|STAS-like-domain-containing-protein
MKHEIRTLIGKNCITPGDGQKVYDLVHPELLALHEVELDFAGVEIVASPFFNFAIGQLLRDIEPETLNRLLKFSNLNTVGKQILKLVIENSKRYYSDPDFRNRVDQVISEQANTQ
>NC_019753.1|WP_015203556.1|2901901_2902507_-|hypothetical-protein
MPVNYTVQAEVVNIRSDAPKNNDIFLVDTNAWYWYTYTNASISSHSYQITEYPSYIAKAISANSLLLYCGLSLAELAHNIEQTQKEIFSSTLKAKEYRHNYPAERANVIAEIQASWSQVTSIAVSTDITVNETITNTCLNRLQTQLLDGYDLLILEAMDKAGIVQVITDDGDYATVPGIKVFTANLNVISTARNQSKLLVR
>NC_019753.1|WP_015203566.1|2914501_2915332_-|alpha/beta-hydrolase
MPEIQSHPCFLTPKKLNPTSPLFVFLPGLDGTGQLLRTQTAGLEVGFDIRCLAIPSDDLTNWDVLTDQVVALVEAELLKQPNRSVYLCGESFGGCLTIKVALRAPHLFDRIILVNPASSFNQQFCLRWGSYLTNWVPEFLYRVGAIGLLAFLASLDRIASSDRQALFEAVRSVPQKTALWRVSLVREFDVNETQLSTIKQPVLVIAGAADNLLPSVAEAERLVNCLPNAEMVVLPDSGHACLLEAEVNLYEIIKSQNFLANREHDMYSIPNKLAIG
>NC_019753.1|WP_015203567.1|2915424_2916147_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MYFDSPLQISNLALTAMGTRMFVYYQDRVPMGSPVLLVSNHRSFMDPPLLMAAIKRPIRFACHHYMGQVPVMRDMVNFLGAFPLEKPEHRQQSFFQQATELLQSRQVVGVFPEGTPPMVKFTKPNTMGDFQRGFAHLAMRAPVENLAVLPVAIASQEEVNNSAIPLKVLSFFDPSEPLFDQGGWHPMVIYRRTSVLIGRPCWITPHSREQYQGKQAKKVVADLIGYCQEEISTLLSQGCY
>NC_019753.1|WP_015203568.1|2916470_2918063_+|methionine--tRNA-ligase
MSLTSTSNNTFAITTPLYYVNDLPHIGSAYTTMVADAVARFQRMRGKSVLLITGTDEHGQKIQRTAEAAGRSPQAHCDQIAAGFELLWQKLNIQYDRFSRTTSPRHAAIVKEFFQRVWEQGDIYLGQQTGWYCVACEEFKEERDLLDQHRCPLHPNKAAEWRDEQNYFFRLSKYQTQLESLYQERPDFIKPVTRRNEVLNFVKQGLQDFSISRVNLDWGFPIPVDPSHTIYVWFDALLAYVTALLEPDSEPTLDNALSKWWPINIHLIGKDILRFHAVYWPAMLLSANLPLPDHVIGHGFLTKNGQKISKTVGNTIDPLDLIERYGAEAIRYYFLKEIEFGQDGDFNETRFVHIVNADLANDLGNLLNRTLKMVQKYCNGIVPNCSGEDIAAEQPLKKIGISLGDRVTQSYENLAFTSGCEAILTLIRASNKLIDEQAPWALYKQGQQQAVEQILYSVLESVRLAAYLLAPIIPEICSEIYNQLGFAINFNDKNLINDATIFSTHTTWGTLPANQQLGEPQPVFARLELP
>NC_019753.1|WP_041226040.1|2918162_2918768_+|NYN-domain-containing-protein
MLDNVSSDSVFTPEQVLVNRGRVAIFIDGSNLFYAALQLGIEIDYTKLLCRLTAGSRLLRSFFYTGVDRTNEKQQGFLLWMRRNGYRVIAKDLVQLPDGSKKANLDVEIAVDMMALVGAYDTAVLVSGDGDLAYAVDAVSYRGVRVEVVSLRSMTSDSLINVADRYIDLDNIKEDIQKTPRHNYTYRPLSGFGLIDDPEPI
>NC_019753.1|WP_157462432.1|2919090_2920281_+|LPS-export-ABC-transporter-periplasmic-protein-LptC
MKGGGKKFRSLPLIRGGLGWGRTRIYAICLIFLLLVGVSGCGGKKTTQKAPTENEQPTKIEGSLEFNNVTLEQADENGRPLWKVKAKRGVYTQNQKTARVENPTGDLFQDGKLVLRVSANEGEVQQDGQKVFLKGQIVATEIRNGLVLKGQELEWRPKEDLLIIRNNLTGSHPQLQASAKEARYFSRKQQLELFGQIVATAKDPSLQMRTEHLIWQVSQQKLIGDKRIKIDRYQGNQIDSSVVGSFSEVNLQTKIAKLKQNVELTSIDPPVKVNGNSVIWNLNNQVVVADQPLSIWHLQEQVRINGSQGQVDLQQKVAVLTGNVQGVATRNQAKLKTNQIKWEFGNQLITARGNVVYQQVNPPLSLTGSSGLGRLQDQSFVVTGSKGSRVVTEIIP
>NC_019753.1|WP_015203571.1|2920294_2921617_-|peptidase-S13
MLQLFSSGLLSLWLENAGVNAKINPSTLLTWQGVPVFMLPKATEPSVENTLRQYLQQLTAQGMLTANQGIWIQSGSTLLINHQGTVPLPAASLTKTATTLAALETWGTKHQFETLISATGPINNGVLQGDLVITGVGDPFFVWEEAIALGNSLNQIGIRQVTGKLVISGNFYMNYKFDPQEAGQLLQLALNSSTWTPLITSQYLQMRKGTAKPQVVINGGVEVATLPNPYQVLLLRHRSMTLIQILKQMNIYSNNEMSEMLARSLGGHQAVMQIAARAANFPPEEIQLVNGSGLGMENRISARAASNMFMTIQRYLQPQNLTIADLFPVSGRDRAGTMETRHIPTGTIVKTGTLNEVSALSGVMPTRDRSLVWFTIINRGTDITRLRSQQDQLLQKLLQRWEKPLEIPMAIIPRTDTANASKYLGDPGRNEIASKTVKVN
>NC_019753.1|WP_015203572.1|2921787_2922822_+|phosphate-acyltransferase-PlsX
MASTRARIAIDAMGGDHAPAEIVAGAIRAQEELDVEVLLVGDPQQIEASLKQHNSSHHIEIVPAEGTIEMEEEPLSALRRKPKASINVAMQLVKKKQADAVVSAGHSGAAMAAALLRLGRLPGIDRPAIGAVLPTIVPSKSVLILDVGANVDCRPKFLEQFAFMGSIYSQYVLGVDTPKVGLLNIGEEPSKGNDAALRTYQKLEENPNITFLGNAEGRDVLSGQFDVIVCDGFVGNILLKFAEAVGGVMVQILKEELPKGLHGKVGTALLKPNLERIKQRFDHAEHGGALLLGVEGICIITHGSSQAPSIFNAIRIAKEAVDNEVLERIQSQTRIAAAQATDGD
>NC_019753.1|WP_041226634.1|2922827_2923838_+|ketoacyl-ACP-synthase-III
MKPSGVGIAITGSGSAAPAEIVDNQKLTQVVDTSDEWISTRTGIRQRRLATNQDSLTALASVAAQKAIAMAGITPSDLDLIILATSTADDLFGTACKIQAELGAHRAVAFDLTAACSGFVFGLVTAAQYIRTGVYQNVLLIGADILSRWVDWSDRGTCVLFGDGAGAVVLQANESDRLLGFELRSDGTQNNCLNLAYQAQPKELVDGVAIGHGTYQPITMNGKEVYRFAVQKVPEVIEKALFRAEITVDQIDWLVLHQANQRILDAVAQRMKIPNDKVISNLALYGNTSAASIPIAIDEAVQEGKIKHGDIIAASGFGAGLSWGAAIFKWGRNEEC
>NC_019753.1|WP_015203574.1|2924067_2924967_+|ACP-S-malonyltransferase
MTKTAWVFPGQGSQAIGMGIDLLDLSAAKIKFKQAEEILGWSISEICQAEEKLSRTLYTQPCLYVVESILVDLMRQQGRQPDLVAGHSLGEYVALYAAGVFDFESGLRLVKQRAELMDQVTGGMMIAVMRFDREKLENAIAQTPDVVLANDNSDGQVVISGTPEATQSVIDQVKPKRHLTLNVSGAFHSPFMATAAAEYENLLASVPFADAQVPVLSNVEPLPAVKGDVLKEQIKRQMTGSVRWREICQQLPVENISNVVEIGPGKVLTGLIKRSHPDINLENVSNAADLQLAISYAAN
>NC_019753.1|WP_015203575.1|2924953_2925607_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MQPIEPSRSREPFVSLVLYRAFKWSIIVPALRVYFNAQVYGAENVPTQGPLLVVSNHASDFDPLILSSCVGRPVAYMAKEELFQVPILKQAITLYGAYPVKRGSADRSAIRAALASIEAGWAAGIFLEGTRTQDARIYSPKLGATMIAAKANAPLLPVSLWGTEKILKKGSAIPQKVPITVRIGELIPAPKSSKRDELEAVTQKCADVINAMHDLGR

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Crispr_ID: NC_019753_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_13

3333723-3333813

Orphan

Consensus_repeat	Method
AAATTCTGATAGTGCGAGCATCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019753_13

>merge|NC_019753|13|3333723-3333813|CRISPRCasFinder
AAATTCTGATAGTGCGAGCATCTTGCTCGCGTTTTTGGAATATTACTGAATAATTCTCAAAGAACAGTAAATTCTGATAGTGCGAGCGTCT

>NC_019753|13|12|3333723-3333813|CRISPRCasFinder
AAATTCTGATAGTGCGAGCATCT	TGCTCGCGTTTTTGGAATATTACTGAATAATTCTCAAAGAACAGT
AAATTCTGATAGTGCGAGCGTCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015203923.1\|3346667_3347147_+\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NC_019753.1\|WP_015203908.1\|3328111_3329209_+\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|381104
NC_019753.1\|WP_015203921.1\|3345758_3346004_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|372995
NC_019753.1\|WP_015203905.1\|3321709_3322738_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NC_019753.1\|WP_015203906.1\|3323275_3325951_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|223715
NC_019753.1\|WP_015203909.1\|3329258_3330668_+\|aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|237031
NC_019753.1\|WP_015203922.1\|3346015_3346405_-\|KGK-family-protein	unknown	unknown	gnl\|CDD\|370166
NC_019753.1\|WP_015203907.1\|3325947_3327798_+\|response-regulator	unknown	unknown	gnl\|CDD\|236901
NC_019753.1\|WP_157462329.1\|3337030_3341491_-\|nitric-oxide-synthase	unknown	unknown	gnl\|CDD\|376957
NC_019753.1\|WP_015203916.1\|3335825_3336815_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_019753.1\|WP_015203915.1\|3334711_3335773_-\|anthranilate-phosphoribosyltransferase-family-protein	unknown	unknown	gnl\|CDD\|168934
NC_019753.1\|WP_157462442.1\|3344426_3345713_-\|PBS-lyase	unknown	unknown	gnl\|CDD\|379311
NC_019753.1\|WP_015203911.1\|3332114_3332303_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015203913.1\|3333275_3333692_+\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|376751
NC_019753.1\|WP_015203912.1\|3332623_3333142_+\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|238239
NC_019753.1\|WP_015203904.1\|3320503_3321451_-\|GHKL-domain-containing-protein	unknown	unknown	gnl\|CDD\|226654
NC_019753.1\|WP_041226063.1\|3343364_3344291_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015203918.1\|3341717_3343127_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015203910.1\|3330780_3331749_+\|DUF362-domain-containing-protein	unknown	unknown	gnl\|CDD\|224917
NC_019753.1\|WP_015203914.1\|3334048_3334498_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224854

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015203923.1\|3346667_3347147_+\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	7.01961e-41
NC_019753.1\|WP_157462442.1\|3344426_3345713_-\|PBS-lyase	gnl\|CDD\|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	3.56831e-08
NC_019753.1\|WP_015203921.1\|3345758_3346004_-\|HNH-endonuclease	gnl\|CDD\|372995	pfam14279, HNH_5, HNH endonuclease. This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.	3.97384e-24
NC_019753.1\|WP_015203905.1\|3321709_3322738_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	6.91419e-23
NC_019753.1\|WP_015203906.1\|3323275_3325951_+\|PAS-domain-S-box-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.41289e-48
NC_019753.1\|WP_015203909.1\|3329258_3330668_+\|aspartate-ammonia-lyase	gnl\|CDD\|237031	PRK12273, aspA, aspartate ammonia-lyase; Provisional.	0
NC_019753.1\|WP_015203922.1\|3346015_3346405_-\|KGK-family-protein	gnl\|CDD\|370166	pfam08872, KGK, KGK domain. This presumed domain is found in one or two copies in cyanobacterial proteins. It is named after a short sequence motif.	1.79887e-30
NC_019753.1\|WP_015203907.1\|3325947_3327798_+\|response-regulator	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	8.18388e-41
NC_019753.1\|WP_157462329.1\|3337030_3341491_-\|nitric-oxide-synthase	gnl\|CDD\|376957	pfam02898, NO_synthase, Nitric oxide synthase, oxygenase domain.	0
NC_019753.1\|WP_015203916.1\|3335825_3336815_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	3.11479e-47
NC_019753.1\|WP_015203915.1\|3334711_3335773_-\|anthranilate-phosphoribosyltransferase-family-protein	gnl\|CDD\|168934	PRK07394, PRK07394, hypothetical protein; Provisional.	0
NC_019753.1\|WP_015203908.1\|3328111_3329209_+\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|381104	cd17552, REC_RR468-like, phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains. Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	4.66712e-31
NC_019753.1\|WP_015203913.1\|3333275_3333692_+\|aspartate-1-decarboxylase	gnl\|CDD\|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	4.07509e-71
NC_019753.1\|WP_015203912.1\|3332623_3333142_+\|inorganic-diphosphatase	gnl\|CDD\|238239	cd00412, pyrophosphatase, Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.	2.71173e-82
NC_019753.1\|WP_015203904.1\|3320503_3321451_-\|GHKL-domain-containing-protein	gnl\|CDD\|226654	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms].	1.78052e-53
NC_019753.1\|WP_015203910.1\|3330780_3331749_+\|DUF362-domain-containing-protein	gnl\|CDD\|224917	COG2006, COG2006, Uncharacterized conserved protein [Function unknown].	6.2524e-134
NC_019753.1\|WP_015203914.1\|3334048_3334498_-\|hypothetical-protein	gnl\|CDD\|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.4816e-05

>NC_019753.1|WP_015203913.1|3333275_3333692_+|aspartate-1-decarboxylase
MQRSLLLAKIHSCTITDANVNYMGSISIDQALLDASGILPYEQVQVVNVNNGERFITYAIAAPANSGAIELNGAAARLGVKGDRLIIMTYAQFTPEEIKTHAPKVVMVDEQNHLLEVRRYNELQNNGFHAELIHSLRL
>NC_019753.1|WP_015203912.1|3332623_3333142_+|inorganic-diphosphatase
MDLSRIPAQPKPGLINVLIEIPAGSKNKYEFDKDLNAFALDRVLYSSVQYPYDYGFVPNTLADDGDPLDGMVLIDQPTFPGCVIAARPIGMLEMIDGGDRDEKVLCVPDKDPRYTHIKSLKDLAPHRLDEIAEFFRSYKNLEKKVTEILGWQDVDQVMPLVEKCIKAGSQKS
>NC_019753.1|WP_015203911.1|3332114_3332303_+|hypothetical-protein
MESSSSPSANSSELPANRWAEILGTMIAILTLALPVFAIANFSSSNSLILQQTSYTLPNSGN
>NC_019753.1|WP_015203910.1|3330780_3331749_+|DUF362-domain-containing-protein
MTVSLIRATSYEQALLRESLLTLLEPLGGMKAFVKKGDRVLLKPNLLTGSRPGKECVTRPEIVCCVAQLVQEAGGKPFLGDGPAFGSAMGVAKASGYLPLIQELNLPIVEFHGKRYQTVSEEFNHLLLSKEAIDADVVINLPKVKSHVQLTMTLGVKNLFGCVPGKMKAWWHMEAGKDSARFGTMLVETARAINPNLTIIDGIIGHEGNGPSGGEPRELGVLGASSNVFALDRAFLEILNVDPQIVPTVAASQRMGLCPELADIHFPQLQPTELKLTDWKLPENLVPIDFGMPRVIQSTFKHLYIRFIKEKINNYQLTINNH
>NC_019753.1|WP_015203909.1|3329258_3330668_+|aspartate-ammonia-lyase
MIEATNLAYRIEKDSMGERQIPETAYYGIQTLRATENFPISGIKPLPTYIDACVLIKKATAIANSELGCIPQEIANAIVQAADEVLAGALRDQFVVDIYQAGAGTSHHMNVNEVLANRALEIIGDSKGNYQKISPNDHVNYGQSTNDVIPTAIRIGGLLAIGKTLNPALASAIATLTTKADEFQDIIKSGRTHLQDAVPVRLGDTFGAWAQILSEHQQRIQTAATDLTKLGLGGSAAGTGMNTHPQYRQRVAEILAQLINQPLQPAPNMMAAMQSMAPFVNVSSAIRNLAQDCVKISHDLRLMDSGPKTGFKEIQLPPVQPGSSIMPGKYNPVMAEMTSMVCFQVMGYDSAIALAAQAGQLELNVMMPLIAYNLIHSIEILGNTLSALTRQCILGITANSDRCLAYAEGSLALVTALNPHIGYLNAANVAKESLATGKSLRQIVLEQQLMSEEQLAKVLDLEKMSTVNG
>NC_019753.1|WP_015203908.1|3328111_3329209_+|hybrid-sensor-histidine-kinase/response-regulator
MKKILVIEDEEPLREDILETLECLEYEGIAAENGVIGVKLAQEHLPDLIICDIMMPELDGYGVFTSLRTHPQTATIPFIFLSAKADKSDLRQGMNLGADDYLTKPFTIADLSEAISAQIQKREVIEDQANQKLDELRTNISRSLPHEFRTPLQGILSLSEIVLSDYDLLDSKTMRNMLYEINNSAQRLSKLIHNFMLYAELEVIATDQERVAELRSNQTFTPETLIKYLASIKFQKAERVADLHLNLQDAIIQISEQDLQKVIEEIIDNSLKFSSAGTPIYIESSLKDSKYILSVLNYGQGMTQDQIAKVGAYMQFDRKLYEQQGSGLGLQIAKRLTELHDGSLTIYSNPGKDTKVEIALPIFQE
>NC_019753.1|WP_015203907.1|3325947_3327798_+|response-regulator
MKHRILVIEDVAELRGDIIDTLECLDFEAIGAENGQIGVELAREYLPDLIISDIMMPLLDGYGVLEILSKEEPTATIPFIFLSAKNSTSDIRKGMNLGADDYLTKPFTIAELKEAIAIRLEKQAARKRVEEQLRERETEFRQLVQREEMLKSLTKQIRTSLEIKTIFTTTLSAIRSLLGIHRCSFLWDRTDVMQRYFELINASEDPEISNIPQCNLFLEIAALGELILKSNILQINNVLTDEQLNDISKNQLLALGVTSILAITIKTNSGQIGIIVCENFIQPRVWSNNEVQLLQAVGDQLAIAIDQGELYAQSRFTATTAKIQAAQLEQALVKLQQTQAQLIQTEKMSSLGQMVAGVAHEINNPVNFIYGNVNHIKNYVHDLLELLQLYQQTNPNPSPEVEELSESIDVDFILQDFPKMLNSMQVGADRIRKIVLSLRNFSRLEEADMKPVNIHEGIDNTLLILQNRLKASKSKPAIEVITEYGDLPLVECYAGELNQVFMNIIVNAIDALEDDQSQRQQAGLPDKSYIITIRTQLIEPDHVTIIIMDNGAGMTEQTKKRLFDPFFTTKPVGKGTGLGLSITYQIVVEKHSGKLECISEPGQGTQFWITIPIRQN
>NC_019753.1|WP_015203906.1|3323275_3325951_+|PAS-domain-S-box-protein
MFLNLKKMLAQSFGINFKSTNSTLMPASLEACNSLLCATLDSTADGILVVDTKGKIISYNNTFVEMWGISRVILDAQHDNQLLEVVQQQLKQPEEFIKKVKQLYDQPDIESYDDLELKDGRYIERYSRPQRIEGKSVGRAFSFRDITQRKKAEIALQQAHDQLEITIEQRTQELLQANSQLSQEIIERKKVEIALEQAKAELETKVQERTTALSSAIAQLQQQITERLDAQAELEQSLSLLRATLESTTDGIIVVDLLGKVRSFNQKLIEMWCIPESLILSPDDEQTLAFALDPLKNAQKFLSLVTELSEQPNLHSYDLLELNDGRIFEYYSQPQHLKEEIIGRVWSFRDVTERYLAEQALQQTKAELEIRVQERTASLENAIAQLQSEMAERQRTESQLYRSKERFRNLVETISDWVWETDENYRYTYCSPQIYNILGYQPEQVIGKTLFDSMTAQEVWRVANLFSFITENQQPFKNIETTKIHQDGHPVVLERSAVPIFDCDGNFCGYRGIDREITERKQAEGMLRQQALAFENIYDGIIITDNEGHIIDWNPSAERMFGYTKEEVLGKSTEFLHTPEEAAVINQEIVETVQHYGRWTGEIKFIGKNGTTGVCETVFVPVYNDASDQIAVVGVNHDITERKQAEVEMLKALSKEKELNQLKSRFISMASHDFRTPLSAILISSDLLKAYSHKLTEAKKVGHLNQIQASVRRMTLLLDDILWMGKAASGKIDFKPQKVNLEELCQEVLDEIAIADCNKHQFIYKFQAESSLVEMDRKLIQQMLSNLLSNAVKYSPQEGDIKINITCKDGTAIFQVADSGIGIPSSDQARLFDGFQRASNVGNISGTGLGLAIVKNVVDLHRGTIQIDSTEGVRTTITICLPIMYSKDTTK
>NC_019753.1|WP_015203905.1|3321709_3322738_-|tetratricopeptide-repeat-protein
MNQVVDVEAEFFFQKGLHLNRIEEYASAIASYGKVVELKPDYAEAWYSRGNALYHLRRYAEAIASYDQALEYRPGFHEAWNNRGNALDDLKHYEEAIASYDNAIKFKPDYFWAWNNRGIALKNLGRYSEAIDSYDRAIEFKPNYYWAWYNRGMAMRQIDRLDKAIASLDKALLAKPDFHEAWYHRGIALQNLGLCESAIASFDESLTVQPKNIDAWYFRGLALDSLGRYQQAIASFDKTLEIQHDKYALNAKGLVLLKLGRYQEALISFDKALHIKPDDHTALYNKARCYALQSDADLAIKHLQQAIHLSPDKYRDMARTHSDFEELQQDYRFQALIQERDS
>NC_019753.1|WP_015203904.1|3320503_3321451_-|GHKL-domain-containing-protein
MTNDECIQAEVEQLKSQIVNLQELVEVYQKSAMDKAEKLERSHEELQETQAKLIHAEKMSSLGQMVAGVAHEINNPVNFIYGNIEHINNYMQDLLSLLEIYQEQYPNPTSTIQDEIEEIDLDFLSEDLPKTLSSMKMGADRIRKIVLSLRNFSRLDESEAKAVNIAEGIDNTLLILNYRIKQGIEVIKNYGDLPLVECFPAQLNQVFMNILSNAIDALLEEEFLPKKQIVINTEIINQEQVKVRIRDNGPGIPSEVKSKLFDPFFTTKPVGKGTGLGLSICNDIIEKHCGSIELNSEIGQGTEFVIILPSQQNNN
>NC_019753.1|WP_015203914.1|3334048_3334498_-|hypothetical-protein
MSFKKQLPRLEKPQSSYFVTFVTWERLELSPAARQVVLNACEFFHNQRYYLFSGVVMPDHVHLLIQPFIKVEHEFWSIGSILHSIKSYSAKQIPNVMLHIGKVWQDGRYEQMIKDEKEFQNKWEYIRQNPVKDGLSKTPEEYPFFWESF
>NC_019753.1|WP_015203915.1|3334711_3335773_-|anthranilate-phosphoribosyltransferase-family-protein
MSDAFRELLKKVGSGSHTSKDLTRQEAADAMRMMLLAEATPAQIGAFLISHRIKRPTGEELAGMLDAYDELGSRLQPLTSTDSQVIVLGIPYDGRSRTAPVSPITALILTTVGQPVVMHGGGIMPTKYGIPLIDIWQGLGVNFRLPLSQTQQVFETTKLGFVYLPLHFPLTNKLVEYRDQLGKRPPLATMELMWSPYAGVAQIISGFVHPPTETMFQDAHALRGQKYFTTVKGLEGSCDLPRDRTAIIGIFSNSNLERLHLHPRDYGFAGKEVPLESLTSLIAQMQEVLQGKPSELMQAAIWNGGFYLWRCGVCKDIESGFTEAESLLTSGKVAQKLAEITQVVNDIQLAHQV
>NC_019753.1|WP_015203916.1|3335825_3336815_-|LysR-family-transcriptional-regulator
MRIEQLQAFLAIAEAGNFQQAAKKCGVTQSTISRQLQVLESELGLLLLHRTAQAKLTVGGEIFLPHARKICQEWETATEELADLLAGKQLELCVAAIHSVCSNYLPPVLQQFCRDYPDVQLRVTALGSDRALKVLKDGMVDVAVVMNNRFFTASPEMVVDVLYNEPIEILMAANHPLTEHQQVPWSALLNYPQVVFKDGYGMQRLVQERFSRQGAKLKAVMELNTLDAFRGVVRQGQLIALLPKSALIDAYTDPTLAVRPIASTEDISAGSITDSLTEMGLTRQVVLVTTQDRLQIPPVRHFCKLVRELGQPPVDLVSTIRESAVMPLG
>NC_019753.1|WP_157462329.1|3337030_3341491_-|nitric-oxide-synthase
MPDIQTLNSQHIIHLTEVSATDFPVSSQYKYKCRVQLISHEGETLLQKDLFSRMQPSWLVELKNKGNCTIALTLCYRQGDISNPWQDAGTVIFETQEYLNGDPNADIEFPITTWEEAPQLKLKVRLTESTREGSSSTITLLSTQKSSRRRTQSTAEKVEVDLPQPTSLTPQEEVIVKDSWNKLRAWKELQMEKFLKRLLLEEPEIEYLFGEAIDSISDFFYELFDCAIHQLQPETQNIVGEPLMGVPPEKGDELDTVEDYGKFFAEIGMRPQHWIKARQVWMWMLPSVPYLEEYDREDLKKGAGSALYKFFNIYIILPMAAAVRRYEEALPPELLQEMADCWQVFSQNKQQMGMEFYQILFEKYPFVLPIFGRSDMDYLSLHLFQALEFLVRCLETGSSEEMLQELRSLGQVHRFADVPSCAYPAIGETMFALFERYLPNFTPELRQGWATLLDRVISVVKLPMLNQERFLKKAKQYLDLISSEQAWELEDRERRWKEIREEVQATGTYTQTYEELAYGTQVAWRNASKCVGRIAWNNMVVRDRRHVTDPDEMFRECQEHVKFATNGGNLQITMTVFPPKQPKERWGSRFWNSQLYRYAAYEMSDGSVMGDPANLELTNAIIKFGWQPPEPRTPYDILPVVIEVPGQEPKMYHWQPEEVLEVHIEHPTIPEFKDIGMRWYAIPAISNFSVHIGGIHYGCMPFNGWYMDTEIMRDFLDEYRYNKIEEIVKVLKLDTSSEQTLWRDRAALELNIAILHSFQKAKVTIVDHQTASRQFLTHDLREKKAGRECPGDWGWVVPAAGGSACPVWHHQMRDFYLEPAYHHAADRWAVEDGIDLEKLTAVVDEDGDKHDSRSETLRDRILILYASETGTAEGFARKAARQLQQFRPKVMALDEYTVETLANEKLLLIVTSTFANGEMPSNGKRFLQWLKKQPAGSLDGLNYSVLGIGSTVYEQFCAAGISVDKALAKAGANRAAPLHKGDEIKGQADTFKQWLGLISRLLGEDATAGDAASATAPKLAVTFLDEANLPPLPAPSSERGIPVPVIAKKELLQEVIPGSRSTRYIAFDISNTDLQYETGDHVAVYPCNPPELSDRLCARIGVSPNTYFTANYVTPDGTVTDDQPPVAVPTTVGQLLSEELDLALREPFNELLAYLYSTAQNSQEKHRLETWLDILRQGEDHPDSVTLKKTITDTCMSVADLFDKFPSAPVTLEALLELLPKQKPRLYSISSCPLLHPNQIQITVGVLQIRTDAGKVRQGLCSNYLAKLRPGSKVRIGVRTSGFRPPADPQAPMLMVGPGTGVSPLIAFLQYREALQKQGTTLGEACLYFGCRDRTDFIYGKRLINWRNQGVLSGLEVAFSRLTDKKVYVQGLMQEKATELWQLLSHPQCHYYVCGDAKMADDVFEAFMAIAKTSGKLSHVEAAAFFDQMKREKRFHTDVWGVQLNFKQAIQQVQKDNYSKAEKWLERVNQSTDQSLATQERQALMV
>NC_019753.1|WP_015203918.1|3341717_3343127_-|hypothetical-protein
MTSQILVKKSPIRRNSWLEKIIALIAVINFCLVLFNISYIHWRDVYLNEIPILTQLYDPIQGIEPHRETARYLEQVNKLQEQITQNGLASTEVEQLLEKLRFLSNEMIEDNPFAGANKSGLLEKIKHDIRDRVGIRSAHQAFATFWSQEHLAAVGWQQEINFFNTKIRPLMNYNYYRGIDINGKFVDKFWQIDLPFVIIFSLEFLARTFYISRRNPHLNWLEAILRRWYDLLLLIPFWRGLRIIPVTVRLYQSELLNLEPLRAQLNHDFVANFAEEITAVVGVQIINQIQEIIKRGEAARWLLHPETRRAYVQVNPVNEVSAIASRLVNLSVYEVMPKIQPDLEALLHHNIENALKQIPGYQQLNHLPGLNHLPTQITQNLVNTLSDKAYGTLVNAVQDPAGAKLTARLSKNFINALDVELQKPQNLQEIQSLLIDMLEEIKINYVKGIAETGVEKTLDETQKVQRLNN
>NC_019753.1|WP_041226063.1|3343364_3344291_+|hypothetical-protein
MVMLDDFSLIEKFIKGEGELLSNPNLRVESTFKTDQLLARNGTVVAVIADKNPVKAVSVNTASKHFYLMSQVLLTHTFAPVGEIKGSKLIQYEPHEIPAGYKVNYTPVKTLFKKWWTQHRASNEHEIKLDLLILTRSKWYPIRSISHNLGGLFFKTLVDEIYVNNEDGMVWLSRITDSQIEDNINSITAQSINADNQPLSEQVPQIDHNQIQGAEAILPIAIRIFNGCLKAGKTQEIKPGVWLAKGAGYNLIYKPDTQDFSIVANQRGVVCKYKGKVVEDANNLKSEDMELWRKIKDKLESQNLKIKE
>NC_019753.1|WP_157462442.1|3344426_3345713_-|PBS-lyase
MLNILSQAQTAAQQKDWSLVSQYLQQLITAKPEKNPETASQLTTAELEQVLYLALEVLNAGDFQERWDVAKVFPKLGENAIAPLITIMQDEDAEIELRWFAGRILAGFNHPTVVTSLIELIQSTEDEELVEMARTGLINLGSSAIDALTGLLSQEESRLLAVRSLAQIRSSQTIAPLLTVVKDQNVTVRATAIEALSSFHDARIPPILLSALQDLAAPVRKQAVVGLGLRPDLRDELDLVNHIKPLLYDFNIDVCGCAAIALGRLGTDDAATALFSILKSPATPEVLQLTVVRALAWINTSYSLDCLRQGLTSTPSVSQEIIMQLGRIEKPLKSQAADILIEFINSEQLAQQTNLKNSLALALGQLGEIKAIDTLIQMLADSDVQLHAIAALKTLAPQQAHQQLQQLAADTQLSVELKQGIAIALQEW
>NC_019753.1|WP_015203921.1|3345758_3346004_-|HNH-endonuclease
MSKTPRIRIPPEVRKYVYDRDRYHCQSCGKTQLETELTIDHIIPLATGGSNDISNLQTLCRICNQRKQHYIDPRFRRHFDL
>NC_019753.1|WP_015203922.1|3346015_3346405_-|KGK-family-protein
MNNQFRPLDSESEENDIAVLFSETGSIFKVGQLISAFNEVLKDQALYTLRQILGSKGIIPDDVFERACDCEILKPGSKGWKKGRVKIRISLEFCPDEPEDTETPENNQPETNEPESPLDDLRRMINEQT
>NC_019753.1|WP_015203923.1|3346667_3347147_+|MgtC/SapB-family-protein
MNSLYINPHDWLNLTIRLTLALIAGGVVGWNRQLSGKAAGLRTHMLVSLGAALFALVPLIASNSPSVDSLSRAIQGVATGIGFLGAGEILHQSTQETGKPQVRGLTSAAGIWVTAALGLIAGCGLWELGAIGTLMTLFTLSVAKKIEKVAFKNRDKNEI

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Crispr_ID: NC_019753_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_14

3468402-3468506

Orphan

Consensus_repeat	Method
AATACTCATAAACCCGCCCATCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019753_14

>merge|NC_019753|14|3468402-3468506|CRISPRCasFinder
AATACTCATAAACCCGCCCATCAACAGATCGTAAAATGCGTAGGGGCGGGTTGACAGACAAACCTATATTCCCACCAACAATACTGATAAACCCGCCCATCAACA

>NC_019753|14|13|3468402-3468506|CRISPRCasFinder
AATACTCATAAACCCGCCCATCAACA	GATCGTAAAATGCGTAGGGGCGGGTTGACAGACAAACCTATATTCCCACCAAC
AATACTGATAAACCCGCCCATCAACA

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015204036.1\|3469261_3472954_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NC_019753.1\|WP_015204044.1\|3479185_3479974_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226953
NC_019753.1\|WP_015204025.1\|3459901_3460552_+\|DUF4340-domain-containing-protein	unknown	unknown	gnl\|CDD\|379518
NC_019753.1\|WP_041226712.1\|3466317_3467154_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224098
NC_019753.1\|WP_015204027.1\|3462844_3463975_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NC_019753.1\|WP_015204041.1\|3476618_3476840_-\|thiamine-biosynthesis-protein-ThiS	unknown	unknown	gnl\|CDD\|180978
NC_019753.1\|WP_015204031.1\|3467571_3467802_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204035.1\|3468835_3469186_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204042.1\|3476832_3477921_-\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|235054
NC_019753.1\|WP_015204043.1\|3478141_3479125_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226952
NC_019753.1\|WP_157462444.1\|3464098_3465199_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270308
NC_019753.1\|WP_041226070.1\|3458195_3459758_+\|ABC-transporter	unknown	unknown	gnl\|CDD\|225766
NC_019753.1\|WP_041226071.1\|3467788_3468148_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NC_019753.1\|WP_015204023.1\|3457321_3458131_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|132557
NC_019753.1\|WP_015204026.1\|3460764_3462543_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NC_019753.1\|WP_041226714.1\|3474980_3475220_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204040.1\|3475319_3476300_-\|DUF1517-domain-containing-protein	unknown	unknown	gnl\|CDD\|226808
NC_019753.1\|WP_015204037.1\|3472953_3474669_-\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|373105
NC_019753.1\|WP_157462445.1\|3465363_3466272_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224097
NC_019753.1\|WP_015204045.1\|3480332_3483515_+\|patatin-like-protein	unknown	unknown	gnl\|CDD\|274676

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015204036.1\|3469261_3472954_-\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	2.01882e-99
NC_019753.1\|WP_015204025.1\|3459901_3460552_+\|DUF4340-domain-containing-protein	gnl\|CDD\|379518	pfam14238, DUF4340, Domain of unknown function (DUF4340). This domain is found in bacteria, and is typically between 183 and 196 amino acids in length.	7.9382e-08
NC_019753.1\|WP_041226712.1\|3466317_3467154_+\|ABC-transporter-permease	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	9.35288e-91
NC_019753.1\|WP_157462444.1\|3464098_3465199_+\|extracellular-solute-binding-protein	gnl\|CDD\|270308	cd13590, PBP2_PotD_PotF_like, The periplasmic-binding component of ABC transporters involved in uptake of polyamines; possess the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain that functions as the primary high-affinity receptors of ABC-type polyamine transport systems. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.50378e-127
NC_019753.1\|WP_015204041.1\|3476618_3476840_-\|thiamine-biosynthesis-protein-ThiS	gnl\|CDD\|180978	PRK07440, PRK07440, thiamine biosynthesis protein ThiS.	3.84832e-38
NC_019753.1\|WP_015204023.1\|3457321_3458131_+\|ABC-transporter-permease-subunit	gnl\|CDD\|132557	TIGR03518, ABC_transporter_permease_protein, gliding motility-associated ABC transporter permease protein GldF. Members of this protein family are exclusive to the Bacteroidetes phylum (previously Cytophaga-Flavobacteria-Bacteroides). GldF is believed to be a ABC transporter permease protein (along with ATP-binding subunit, GldA and a sunstrate-binding subunit, GldG) and is linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae and Cytophaga hutchinsonii. Knockouts of GldF abolish the gliding phenotype. Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Bacteroidetes with members of this protein family appear to have all of the genes associated with gliding motility.	1.79986e-30
NC_019753.1\|WP_015204042.1\|3476832_3477921_-\|thiamine-phosphate-synthase	gnl\|CDD\|235054	PRK02615, PRK02615, thiamine phosphate synthase.	0
NC_019753.1\|WP_015204044.1\|3479185_3479974_+\|hypothetical-protein	gnl\|CDD\|226953	COG4587, COG4587, ABC-type uncharacterized transport system, permease component [General function prediction only].	2.76939e-82
NC_019753.1\|WP_015204027.1\|3462844_3463975_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	1.18172e-159
NC_019753.1\|WP_041226070.1\|3458195_3459758_+\|ABC-transporter	gnl\|CDD\|225766	COG3225, GldG, ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion].	4.15161e-94
NC_019753.1\|WP_041226071.1\|3467788_3468148_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	5.35363e-25
NC_019753.1\|WP_015204026.1\|3460764_3462543_-\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NC_019753.1\|WP_015204043.1\|3478141_3479125_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226952	COG4586, COG4586, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	1.05114e-165
NC_019753.1\|WP_015204040.1\|3475319_3476300_-\|DUF1517-domain-containing-protein	gnl\|CDD\|226808	COG4371, COG4371, Predicted membrane protein [Function unknown].	6.3737e-109
NC_019753.1\|WP_015204037.1\|3472953_3474669_-\|CHAT-domain-containing-protein	gnl\|CDD\|373105	pfam14516, AAA_35, AAA-like domain. This family of proteins are part of the AAA superfamily.	0
NC_019753.1\|WP_157462445.1\|3465363_3466272_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	1.22233e-83
NC_019753.1\|WP_015204045.1\|3480332_3483515_+\|patatin-like-protein	gnl\|CDD\|274676	TIGR03607, TIGR03607, patatin-related protein. This bacterial protein family contains an N-terminal patatin domain, where patatins are plant storage proteins capable of phospholipase activity (see pfam01734). Regions of strong sequence conservation are separated by regions of significant sequence and length variability. Members of the family are distributed sporadically among bacteria. The function is unknown. [Unknown function, General].	1.03273e-87

>NC_019753.1|WP_041226071.1|3467788_3468148_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MPRGDLTYKRGDIRWVNLEPTIGAETRKIRPCLIVQNDVINQYGLLTIVMPFRPGNKKAPYVVNVKATIVNGLDRDRFIDVGQIRAVDHSRILEMVGVLEEEYYLEIQTAVNVVLGFAT
>NC_019753.1|WP_015204031.1|3467571_3467802_+|hypothetical-protein
MFKVTVTIDNDILRFIDEQAQGNRSGYINAVLTEHRRCVLEAEMIAALKQDIEDTEYQAEIAAWDRVVGDGIHAEG
>NC_019753.1|WP_041226712.1|3466317_3467154_+|ABC-transporter-permease
MDNQQEEIPLEMLQSKNKPRPSWQVIFTLLMFFYMYLPILVLTFYSFNESAYSAGWQGFTLKWYQKLFSDSRILTALQNSLIVAIGAVAISAVLGTLMAVGLARYRFTGKTLYRGVSYLPLIIPDIAIAVATLVFLASVGIPLSIWTIVAAHVVFCISYIALVVSSRINNINPHLEEAALDLGATPVQAFIQVLLPELMPAIIAGCLLAFVLSMDDFLIASFTAGTGSTTLPLEIFSRIRTGVKPDINALSVFLMVLSGLVAFIAEVIRYRGEQKRSI
>NC_019753.1|WP_157462445.1|3465363_3466272_+|ABC-transporter-permease-subunit
MPNSTPSDDVNELLVTGKERRGFKWLEPLILLAPGGLWLALLLVVPALVIFELSLVPNIRPGDVVNPTGLANYTLIFQPIYLQVLGRSLFFALGTTIVTLLLGFPVAYWLGQMAPKQWRNLLVLGFVLPLWTSSLLRSYAWITILRPTGVLNSFLTSLHLPTVELLNQSTAVFIGMAYSYLPYMVLILYASVEKLDQRLLEASADLGANPIQTFWKVTVPQTMPGIAAGSLLVFINTLGDFVDPELLGGASSMTVSRLIYNQFLGATQNWGFGSSLSMILIFAVSVAIALLIKYGGDATPQR
>NC_019753.1|WP_157462444.1|3464098_3465199_+|extracellular-solute-binding-protein
MNSTRRRFIQTSAAALSGLALSSCGWTLAQVRSTPTNAGRGDNKLLYIYTWAGYTDEDLLNRFTQDTGIKVIADVFDSNEAMLAKIQASGGGEYSIIYPSDYMVRQMVELKMLTELDHSRLLGLDQLFPKFQNPTYDPDNRYSVPMTWGTTGLIYNTTKLKNQPQDWNYLWDQQKQLSRKMTLQNDLREVMGATLKMLGYSYNSTDPQQIKQAYEKLAQLKPSIASFTSDAWRSQILTGDLLVAMCVSSDANDLIPEAENLQYVLPRSGSSLWTDTLVIPKTAPNPEAAYAWINYMLQPEVTAAICQRLSFATPNKVAFNLLPPDVRDNPVLFPPESLLAKCEGIAPLPDKVKEIYEAYWTKLTSS
>NC_019753.1|WP_015204027.1|3462844_3463975_+|ABC-transporter-ATP-binding-protein
MSLTSAQKQLYPETTAELDIELRRVFKVFNGETAVRGVDLEIHRGEFFSILGPSGCGKTTTLRLIAGFDSPSAGEVLIQGQSMNHVPPYRRPVNTVFQSYALFNHLNVWENIAFGLRIKKLSASEVEYRVKEALKLVKMEAYTHRFPSQMSGGQQQRVALARALVNRPTVVLLDEPLGALDLKLRKEMQVELSNLHQDLGVTFVMVTHDQEEALSLSDRIAVMRAGKIEQIGTPTEIYERPRTQFIADFIGDTNLFQGRIEAADASSLEIVTNNNLRIVVEPSDHRDQNVSTHEVSVSVRPEKINLSLSAPATSVNCFEGRLKHVMYLGTHVHYVVELLTGDRLTVRQLNTNGSLFEPHTPIYVYWEAKDCLALKD
>NC_019753.1|WP_015204026.1|3460764_3462543_-|penicillin-binding-protein-2
MTFVQPSSDRGQKSTLNVGRTNKPLILMLIVTLTMMGGIGARLAYLQIIQGQENRELAQDNHIRLIPKLPVRGNLLDRKGRLLAGNRLTYSVFLWPMAPKQPDWQKTKERLSQVLNMKEEEITQLLAKAGYNPSMRVRLARNITPAQITALAEYGNDLDGVEVDIEAIRSYPNGDLAAHVLGYTGEMSTEELVKRRSEGYRLGDFVGQMGVEAAFEKQLRGEWGGQQVEVDGSGQVVKILGQKESKPGTDVHLTLDLDVQKAAEAALGNRQGAILAMNPQNGAILAMASRPTFDPNIFSKRITPETWQKIQSEDHPFVNRAIRGFPPASTFKIITTTAGIESGKFSENTRLQTYASLTIAGRKFADWNHAGFGVLGFAGALKWSSDTFFYQVGKEIGGQTLIDWTHKYGFGQKTGIELAPEEAAGLVADETWKRKRLREPWTVGDTVNMSIGQGFLQATPLQQAVMFSVPANGGYRVKPHLLKDDEESKQWRESLNLKPQTIRVLRQGLRAVVDGGTGAALNSPTLPTTAGKSGTAEAPPGEPHVWFGGYAPAEKPEIVVVAFGEHEGANGGGGKIAAPMVLKVMEAYFKKQ
>NC_019753.1|WP_015204025.1|3459901_3460552_+|DUF4340-domain-containing-protein
MKLQWTTWILVLLALGLGGFVYFSEMKPARQQEAATIKERKIFDFDKDQIQSFTIKTPEQLLKFERVQQAGIEFSKSPWQMKFPVDKPASDPSVAFLLNLLVSAKSDRILTVAADEIQQYGLDQPQAIVEIKLKNQQTHQLILGKSNFNNTFLYAQVDPPTDKPQQRQLVLLTKDLENAVKRPLPEWQSKPASQDKSQTNSKKSTPEQPKLIIPSP
>NC_019753.1|WP_041226070.1|3458195_3459758_+|ABC-transporter
MKTITKNRQYLEYLFLLGPILCIMGLVAQYVSGTRSLIPLTLLITGIVIIILWLFIGSAARKFWGRRSTQVSTNAIVATLAVLGILALINFLAVRHAVRLDLTENQLFTLSPQSQQVVKSLQQPVKLWVFESNQNPANRELLENYRRSSSQFSFDFVDPELKPGVAQQFGVKSAGEVYVESGKKRQLVQNLQPGDSLSEAKVTNGITQIFSDRQAKIYFLQGHGERPLDSVQGGISQAISRLQDQNFTAQPLNLAQKSAIPTDAAAVVVAGAKRALFPGEVNALKNYLSGGGSLLIMVDPKTDLKLDSLLQEWGVKLDNRLAVDASGKGRLVGLGAATAVVTQYSQHPITKDFGNDISFYPLSRPIEITPVKGIEQTPLLITDNQSWAESNSEGEQLEFNADSDRQGPLTLGVALAKTNSTPSATQANQDTTSSRLVVLGNSEFMTNGLFEQQLNGDVFLNSVSWLSKQDQQVLSIRPKEAKNRRINLTPQLGQLLTWTALLIIPLIGFTTAGMMWWRRR
>NC_019753.1|WP_015204023.1|3457321_3458131_+|ABC-transporter-permease-subunit
MNVIIANILAIYRKELQGYFASPLAYVVAAVFWLLSGFFFVAILLGPEGIIQQAALRDLQGQQVEFTPPLDVPYEFLRIFLGVMGSLALFVLPILSMGLYAEERKRGTLELLATSPLTNWAVAVGKLLGVLTFFITMVLPLLLYEAIAFSAAKPSIQPGVPILAHLGLILLAAAVLSLGMFISSVTDSSILAAFMTFFLVLSLWIIDLMAKSIGGPIGDAISHLSLLKHYNNLIQGVLDTSSLIIFVSYIVLGIFLTAQSIEALRFQRS
>NC_019753.1|WP_015204035.1|3468835_3469186_-|hypothetical-protein
MGQLTPIELEDGTVIYIEAAEKTPPGLTNPQRGLFPDDPQKQITQSFHAIEGTIRAYTTHTLNAFRNLAIAEVSEVNLKFGVNINATSGVPYIAAGSAGCNVEISVKCVFPQKSEE
>NC_019753.1|WP_015204036.1|3469261_3472954_-|hypothetical-protein
MAATPPSKYQYQVGGSLPVDAPTYVRRKADQELYDCLKAGEFCYVLNSRQMGKSSLRVQTMQRLQNEGFACAAIDITAIGTFGITAEQWYAGIIDSLVGSFNFYKNFDLELWWTSQELLSPVQKLSKFFEIILLPAIDQKIVIFIDEIDSILALEFNIDDFFAVIRDCYNRRADKPEYSRLTFALLGVATPADLIKDKRRTPFNIGRSVELDGFCLEETEPLIQGLASKVSSPQSVMAALLKWSGGQPFLTQKLCDLILLTNSEPTVGSEIEWVADLVQLAVIDHWEAQDTPEHLKTIRDRILYSTGQRTGRLLGLYQQILQLGEVVANDSPEQMELRLSGLVFKRDGKLQVYNPIYAAVFNFEWVEEILASLRPYAQAITAWSESGYEDESRLLRGQALIDAQTWAVNKSLGDQDYRFLDASRELKRQELERELETTQSILNVEKAKLTKIRKQARRVEKESKAAREAVKFANLEIAVVNTKLKTAYSKAFFSDGQILKALLEVLQAAQPLKTIDKSATQQEHIKMEVIAPLRQAVYEVKERNTLTGHSGSVYSVIFSPDGQTLASASDDKAVKLWKLDGTLITTLTGHSSLVYSVIFSPDGQTIASASDDKTVKLWKLDGSLITTLTGHSGSVYTVIFSPDGQTIASASDDKTVKLWKLDGSLITTLTGHSGSVYSVIFSPNGQTLASASDDDTVKLWKLDGTLITTLTGHSGSVYSVIFSPNGQTLASASDDNTVKLWKLDGTLIITLTGHSSLVNSVIFSPDGQTVASASTDNTVKLWEFWKSHSSLRTTLTGHSGSVYNVIFSPDGQTLASASGDKTVKLWKLDGTLITTLTGHSDPVNSIIFSPDGQTLASASGDKTVKLWKLDGSPITTLSGHSGSVYSVIFSPNGQALASASGDKTVALWKLDGTLITTLTGHSDRVISVIFSPDGQTIASASGDKTVALWKLDGTLITALTGHSGSVYSVIFSPDGQTIASASTDKTVKLWKLDGTLITTLTGHSDPVNSAIFSPDGQTIASASFDKTVKLWKLDGSLITTLTGHSDPVRSVIFSPNGQTLASASTDKTVKLWKLDGSLITTLTGHSDRVWNVIFSPDGQTIASASFDRTVKLWKLDGSLITTLTGHSGSVYSVIFSPNGQTLASASTDKTVKLWKLDGTLITTLTGHSGWVNSVIFSPDGQTLASASADKTVKLWNFNLDSLTAMGCNWLQDYLHTHPEDKQKLKICQTQ
>NC_019753.1|WP_015204037.1|3472953_3474669_-|CHAT-domain-containing-protein
MSSPGRKKRTILVLAANPKNSTPLRLDEEVREIDAGLRRAQKREEFQLEQQWAVTPRDMQRAVLEFNPQIVHFSGHGVGEGGLALEDEHGQAKLVSAKALAGLFELFMDQVECVLLNACYSEVQAQAIACHIPYVIGMNQAVGDTAAKEFAVGFYDALGVGKSIEFAYKLGCSSIRMAGIPEELTPVLIKKSDIIAQGSDICLLATEVEAAVVLEPRSPSVVEVPVAPFCLDNPEGSVSLDSSFYIERPPIEVDRYETVVKPGALIRVKAPRQMGKSSLLQRILYHARQQKHQTAYINFQSADAEFFTNIDLFLQWFCASVSNELNLDERLDDYWKWGLGSKNKCTNYFQRYLLSTIAETSETLTLGLDEVDQIFQYPEIAQDFFGLLRAWHERGKNEAAWKNLRLVIVHSQEVYIPLNINQSPFNVGVPIDLPELNQRQVTELIKRHGLNWSISEIEQLIGVVDGHPYLLRKALYEITRGSLTLEKFLQVAPTEEGLYGDHLRRHLFNLKENPCLEGAMKEVIASNVPVRLEPSQAFKLRSMGLVKLRGNDVIPLCNLYRIYFCDRLGVH
>NC_019753.1|WP_041226714.1|3474980_3475220_-|hypothetical-protein
MKIKAIKRGQTIELLEPINISDGEIIIDIDEQQSSDVKPNFWEALQEFRQQVNLEELEIEPEEIFAGLRDKSPGRDVIL
>NC_019753.1|WP_015204040.1|3475319_3476300_-|DUF1517-domain-containing-protein
MRNKLFSHIKPFFKPLIALALMMVLTLGTAGDALAARSGGRMGGGSFSRSPSYSAPRTYSPGGGGGYYPRGGGYYPGGGGFGLPFLLPFFGFGGGVGSLFGIFIFIAIANFLVQSFRRVGAGNDTESLGYDNSQVSVARVQLGLLAQARELQTELNDLARTADTSTAEGRAQVLQESALALLRHPEYWVYGAGQFEKTGLALAEAKFNQLALAERSKFTEETLSNVNNQLRQASSNAALTAGGGQLAEATQAPSEYILVTLVVGFDGNLQLPTINSSDDMRQALRQIGSISSDRLLAVEVLWTPQAEGDTLTTDDLLAYYPDLKLI
>NC_019753.1|WP_015204041.1|3476618_3476840_-|thiamine-biosynthesis-protein-ThiS
MSNGTVEITLQVNGEPRTCPPQTRLPQLLEQLGLNPRLVAVEYNGEILHRQFWSETEMAEGDRVEIVTIVGGG
>NC_019753.1|WP_015204042.1|3476832_3477921_-|thiamine-phosphate-synthase
MGDKNNNINFIQPAVYRILDANLDRAREGLRIIEEWCRFGLNSGQLANECKQMRQELAGLHSSEIRAARDTPGDPGTELTHPKEEQRSGIEQLLQANLCRVEEALRVIEEYGKLYSTQMSADVKQMRYRVYTLESNLLAYRRHQLLKRSHLYLVTSPSENLFNVIEAALQGGLTLLQYRDKTSDDSIRLSYAHKLRQLCHHYGALFIINDRVDLAVAVDADGVHLGQQDIPVAFARQILGTQRIIGKSTTNPDEMQRAIQEGADYIGVGPVYETPTKAGKAAAGVEYVQYAAKNSPIPWFAIGGIDMNNLNDVLKSGAERVAVVRAIMEAEQPTLITQYFHSQLTRVQTLRSIEPQVVQSHV
>NC_019753.1|WP_015204043.1|3478141_3479125_+|ATP-binding-cassette-domain-containing-protein
MPILVAENLSKVYPVAVKEPGIKGTLAHFIRRNYRQVNAVQNVSFEINAGEVVGFLGANGAGKTTTLKMLTGLIHPSGGKVRVAGFVPFRRQEAFLQKITLVMGQKQQLLWDLPAIDSLNINAAVYGIPEDEYRKRIGELVEMLSLQGKLNQPVRKLSLGERMKAELLAALLHHPQVLFLDEPTLGLDVNAQVSVRDFLREYNQRYQATIILTSHYMADITALCQRVMLIHAGQLIYDGKLESLLDRFAPYREVKVELAQPLPAEKLVHYGEVESVEGREVRFLVKRETLTRTVAQILAELEVMDLTVTDPPVEEVIGRVFTAGVVE
>NC_019753.1|WP_015204044.1|3479185_3479974_+|hypothetical-protein
MKRLIRTTTTFLTTYYAHMVEYRAELLFWALSNSLPIILMGVWNQAAQSGKFGLSPIDLVRYFFAVFMVRQLTIVWVVWDFEREVVEGTLSPRLLQPIDPAWHHIAGHISERIARIPFTVGLVILFFVLYPQAFWIPKLQTLLLCLIATLLAFVLRFIIQYTFGMLAFWTEKASAIEQLWYLFYLFLSGLIAPLELFPETVRNVVQWTPFPYMIHFPAAILIGLPVNIGQGLLVIIGWSVFFFVLNRWLWRKGLKHYSGMGA
>NC_019753.1|WP_015204045.1|3480332_3483515_+|patatin-like-protein
MSSRLDKPEFSREHRLGLVVYGGVALAIYMNGICQEFYNAVRGRGIYKLIKALTDADIVVDIISGTSAGGINGVLLSYALANSQGKNCIKFDKFADVWKNSGDINKLLFDPKEYSGLDISSFFNGVGYYKKEIKEALVARIKDLKENAPEDDWVSEIKELDLFITGTDTMGKINQVFDNTNRVIELKDHQAIFHLKYRDYADNPFNPDDITCEALAKLCQITSCFPVAFPSVTVKLEPLDKNDPDKKLIEWGDLTNRIVPENKPKLDNSLSLKQHNKKGKKLSDIEDDPGAGYRLHFVDGGVLDNRPFSYTIKEIYHREVDRRVSRKLFYVDPSPDRFKGNSEYENMLKPNIVRVVQDSLIAMPRYESINKDLELINEHNEKVRRYKFLLADLETLLDIEEKDQENNDFYDQQRNVYLRTRLISLENKILPLIFLKSEGLVKASQQEKNRTNKLEKAAKLLAEPFTTPQASSKRLKLLEQLEKDICHLDVDYTLRKYFFITEYVYRLLDENYLCEWLKSKKKQEIEQSSINDEILINLKLIINKLNKYRKLIETIKSNIDKLFISPEIEKYFLKLLDESNNSSEQFTEKFYRAMLWLHGQFLNTESLSKSENHEFSIKELNKDLTEKIHQIKSLSSLNKFFQLSGEEQLVELQDLAEKSLLKKLVDETKKKLLSSGSGEVEHYNYIKEKLLNYFNQFEKLDTVLYPLDYLAGIPEKQLIETFRISPEDAQLGLSSKFNDGERLEQKLAGDTLRAFGGFFKKSWRANDILWGRLDGLNRIVDALVTEEKIKNFPKLLEIEAEKEAKKKNQPIDRASYLDRLLEEALFSDFDRERSLKSEVDKQYLMDKKKELKEKLEKLFPSLYAPSSGEQPINKEYLQDFINSLVSVGHLVILDQDLIQTMEVSIEEQLDGKQQKVPTDKPDAPLPAEKSDESIAIPKFNRIDFSFDSAITALVVKQVAKKSLKSISLKEKEDFFNQHYKIGLETFYHIPESERIKLLLKGILIFQDIFLTWQRKTKAKINSNKSKPNPLDFWSRFGWTVVGWMINIAILVINFILWWRF

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Crispr_ID: NC_019753_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_15

3609819-3610066

Orphan

Consensus_repeat	Method
TTACAGCGATATGAAAGTGCGATCGCATCTTACGCTCAAGCAAT	PILER-CR

2 spacers

The CRISPR arrays of NC_019753_15

>merge|NC_019753|15|3609819-3610066|PILER-CR
TTGCAACGATATGAAAGTGCGATCGCATCTTATTCTAAAGCTATAGAGTTGAAGCGAAATAATTATCAAACTTGGTATAATCGGGGAAATTCCCTATATCAATTACAGCGATATGAGGATGCGATCGCATCTTACGCTCAAGCGGTACGCTATAAACCAGATTACTACGAGGCTTGGTATAGTCGCGGGAACGCATTGTTGAATTTAAAGAGATATGAAAGTGCGATCGCATCTTACGATCAAGCAAT

>NC_019753|15|6|3609819-3610066|PILER-CR
TTGCAACGATATGAAAGTGCGATCGCATCTTATTCTAAAGCTAT	AGAGTTGAAGCGAAATAATTATCAAACTTGGTATAATCGGGGAAATTCCCTATATCAA
TTACAGCGATATGAGGATGCGATCGCATCTTACGCTCAAGCGGT	ACGCTATAAACCAGATTACTACGAGGCTTGGTATAGTCGCGGGAACGCATTGTTGAATTTA
AAGAGATATGAAAGTGCGATCGCATCTTACGATCAAGCAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015204150.1\|3607390_3607858_-\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|235455
NC_019753.1\|WP_015201778.1\|3605913_3607014_+\|ISAs1-family-transposase	unknown	unknown	gnl\|CDD\|379382
NC_019753.1\|WP_015204159.1\|3617361_3617556_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204161.1\|3618147_3618600_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_019753.1\|WP_015204153.1\|3611512_3611698_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204146.1\|3600963_3601677_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_019753.1\|WP_015204155.1\|3613060_3613228_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|224514
NC_019753.1\|WP_015204154.1\|3611963_3612962_+\|WD40-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|238121
NC_019753.1\|WP_041226729.1\|3598059_3599169_+\|YjgP/YjgQ-family-permease	unknown	unknown	gnl\|CDD\|367632
NC_019753.1\|WP_041226730.1\|3602658_3604275_+\|GAF-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_019753.1\|WP_015204143.1\|3597178_3597907_+\|LPS-export-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213185
NC_019753.1\|WP_015204157.1\|3613504_3613696_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204149.1\|3604362_3605760_+\|putative-bicarbonate-transporter,-IctB-family	unknown	unknown	gnl\|CDD\|273357
NC_019753.1\|WP_015204152.1\|3610361_3611480_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_019753.1\|WP_015204156.1\|3613296_3613521_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204145.1\|3599277_3600702_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|180944
NC_019753.1\|WP_015204147.1\|3601765_3602491_+\|GUN4-domain-containing-protein	unknown	unknown	gnl\|CDD\|368432
NC_019753.1\|WP_041226734.1\|3614058_3617088_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_019753.1\|WP_015204160.1\|3617682_3618096_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_051035459.1\|3596660_3597107_+\|OstA-family-protein	unknown	unknown	gnl\|CDD\|224845

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015204150.1\|3607390_3607858_-\|SsrA-binding-protein-SmpB	gnl\|CDD\|235455	PRK05422, smpB, SsrA-binding protein SmpB.	1.74995e-90
NC_019753.1\|WP_015201778.1\|3605913_3607014_+\|ISAs1-family-transposase	gnl\|CDD\|379382	pfam13808, DDE_Tnp_1_assoc, DDE_Tnp_1-associated. This domain is frequently found N-terminal to the transposase, IS family DDE_Tnp_1, pfam01609 and its relatives.	3.3717e-27
NC_019753.1\|WP_015204161.1\|3618147_3618600_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.47477e-15
NC_019753.1\|WP_015204146.1\|3600963_3601677_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.61017e-45
NC_019753.1\|WP_015204155.1\|3613060_3613228_-\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|224514	COG1598, COG1598, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	1.52242e-07
NC_019753.1\|WP_015204154.1\|3611963_3612962_+\|WD40-repeat-domain-containing-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	8.04649e-116
NC_019753.1\|WP_041226729.1\|3598059_3599169_+\|YjgP/YjgQ-family-permease	gnl\|CDD\|367632	pfam03739, YjgP_YjgQ, Predicted permease YjgP/YjgQ family. Members of this family are predicted integral membrane proteins of unknown function. They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this.	4.3509e-80
NC_019753.1\|WP_041226730.1\|3602658_3604275_+\|GAF-domain-containing-sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.09604e-14
NC_019753.1\|WP_015204143.1\|3597178_3597907_+\|LPS-export-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213185	cd03218, ABC_YhbG, ATP-binding cassette component of YhbG transport system. The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in cell envelope during biogenesis. YhbG is the putative ATP-binding cassette component and YhbN is the putative periplasmic-binding protein. Depletion of each gene product leads to growth arrest, irreversible cell damage and loss of viability in E. coli. The YhbG homolog (NtrA) is essential in Rhizobium meliloti, a symbiotic nitrogen-fixing bacterium.	7.1924e-144
NC_019753.1\|WP_015204149.1\|3604362_3605760_+\|putative-bicarbonate-transporter,-IctB-family	gnl\|CDD\|273357	TIGR00947, 2A73, putative bicarbonate transporter, IctB family. This family of proteins is suggested to transport inorganic carbon (HCO3-), based on the phenotype of a mutant of IctB in Synechococcus sp. strain PCC 7942. Bicarbonate uptake is used by many photosynthetic organisms including cyanobacteria. These organisms are able to concentrate CO2/HCO3- against a greater than ten-fold concentration gradient. Cyanobacteria may have several such carriers operating with different efficiencies. Note that homology to various O-antigen ligases, with possible implications for mutant cell envelope structure, might allow alternatives to the interpretation of IctB as a bicarbonate transport protein. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NC_019753.1\|WP_015204152.1\|3610361_3611480_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.34431e-36
NC_019753.1\|WP_015204145.1\|3599277_3600702_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|180944	PRK07362, PRK07362, NADP-dependent isocitrate dehydrogenase.	0
NC_019753.1\|WP_015204147.1\|3601765_3602491_+\|GUN4-domain-containing-protein	gnl\|CDD\|368432	pfam05419, GUN4, GUN4-like. In Arabidopsis, GUN4 is required for the functioning of the plastid mediated repression of nuclear transcription that is involved in controlling the levels of magnesium- protoporphyrin IX. GUN4 binds the product and substrate of Mg-chelatase, an enzyme that produces Mg-Proto, and activates Mg-chelatase. GUN4 is thought to participates in plastid-to-nucleus signaling by regulating magnesium-protoporphyrin IX synthesis or trafficking.	6.2235e-91
NC_019753.1\|WP_041226734.1\|3614058_3617088_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_019753.1\|WP_051035459.1\|3596660_3597107_+\|OstA-family-protein	gnl\|CDD\|224845	COG1934, COG1934, Uncharacterized protein conserved in bacteria [Function unknown].	2.39331e-27

>NC_019753.1|WP_015204150.1|3607390_3607858_-|SsrA-binding-protein-SmpB
MSEKSDGFKVVSDNRQARYLYEILETYEAGIELKGTEVKSIREGRSNIRDGYALIRNGEAFLINVHVSPHPTTSQYFNHDPRRTRKLLLHKQEIRKLIGKVEQQGLTLVPLKMYLKNGKAKISIGLAKGKKLHDKRQDLKQRQDKRDMQRAMKRD
>NC_019753.1|WP_015201778.1|3605913_3607014_+|ISAs1-family-transposase
MLVSLIEHLKKVKDFRKSQGKRHPLWIVLLVVVLGMMSGYQGYREIGHFVKYEQRNLINNLEIFTERLPSCATIRRVMMGMDWQNLSEVFNQWAKENYPQIDETDWLAIDGKSLRSTVTNYADKSQNFGVIVSVFSQLTGLVIALSKIENKSKSEIAEVQDIVRNCGFKGKVISADALHCNQTTTRAIIKSQNNYLIALKKNQNKLYEQVKTLTNMIEPSSRCITKEQSHGRQVTREVTVFNNIIKLKNWSHIQSLIKVERWGWRGSSPYQETVYYISSMSADAETFNQRIRGHWRIENQVHWVKDVILNEDKMKIHQIQAATNFSILKTIVLNLFRGLGFISITEGKRWLGNHWNKLLIMTEELT
>NC_019753.1|WP_015204149.1|3604362_3605760_+|putative-bicarbonate-transporter,-IctB-family
MNLVWQRFTLSDLPLSQWRSSSYLYRLVGPLQAWRQSSWLMQWAEGIGAGLISLVFALAPFVANELVGVLLLASAGYWVLLTLSDNTRTAATPINLLVLLYWGIATVATAMSPVKNAAFTGWTKLTLYLLFFALMSRVVRSPRLRSWLITVYLHVALIVSVYGLRQWFFGAAQLATWVDPTSTMSKTTRVYSYLGNPNLLAAYLLPAIALSLAALFAWRGWMPKALALTMFVVNTACMILTFSRGGWIGFVLIVFVFLVLQLFWWSVYLPSFWRKWSLPLLLGSLALVLTLTVAFVDPVRDRVGSMFAGRGDSSNNFRINVWTAVIKMIEDRPILGIGPGNTAFNKVYPLFQVSPRYSALSAYSIVLELAVETGFIGLSCFLWLLIVTFNQGVRQLGRLRKFANGEAFWLMGAIAGMLGLLGHGLFDTVWYRPEVNTLWWFMVAVIASYYNPPRLLMGSHPDEQD
>NC_019753.1|WP_041226730.1|3602658_3604275_+|GAF-domain-containing-sensor-histidine-kinase
MESPESRLFCRLDNFTPAVKEQQRFKILAEFGLLKTDTLPVFEEATQTACRFLETPISIVGLMTEDRQWIKSAVGLSRLGLMNELLTSRQLSRNESFCTHVVDSHQVLAISDTATDGEFSRSSLFQHYGIRAYLGAPLLTASGHCLGTLAVMDLIPRNFSSKDIEFLMLLARLVVTEIERNCLVKAKQTRVLGLHTNSDLHRYSVVPSSVLNKNESLEFACATSVNPAISINSNSHISLSQGNNQSHQSQEFTTQKLKVKLLTHISQELRTPLTSVMGMTSVLNREIYGPLSSKQKEYLNIIHHSGQSLVSLVDEIAALGLLDENNQKLQLTSVNIEMVCQQAIKSLEQVAHHRQQQLRLSVEPGNRIWLVDKDKIRQILYYLLLSLIQSAEVGCVVRIHLSHKSEKLNMALWVSHPWLGDCLPQVELYSESGIAKIANNSELLQDNATVIQDQVADAYLPLGSETLTSTPLVAALMNAEDLNIKSAVGNDSRESLGLLLSCCLAETHGGEILVQGSPEWGYRYVVSLPHIVTGDDPL
>NC_019753.1|WP_015204147.1|3601765_3602491_+|GUN4-domain-containing-protein
MSDLTTTSPDTSDNIADIRYKFKSETEKNQQKLIPEVLSSGDVGLQLLMEFLSERRSSPPSLVDGIAYQALYQANSAKATEFLNTNFPTGIVPLKSERGIDYSPLQKLLAQQDFEEADRLSNLKLCELAGSDALQRKWLYFTEVENFPITDLQTINNLWLLHSEGKFGFSVQRELWLAVGKNWEKLWSKIGWKNGNAWTRYPNEFTWALTAPKGHLPLSNQLRGVRVISSLLSHPAWTMNN
>NC_019753.1|WP_015204146.1|3600963_3601677_+|response-regulator-transcription-factor
MKKILVVDDDRTLRTILSHHLHKQGYQVNEASSGVEALTAFEQEPPDVVVSDVMMPEMNGLEFCRQLRASRFGQLVPFIFLSAKGDLEDRIKGHTIGGDDYLTKPVDPRELIAKIEAQLERSRRIHSEMVMLMQHLASRSPAMPLPPAPEKPLLEKERTVEMVSTQPVDLPLTPAEARVFWEVIQGFTNKQISDRLFISPRTVQTHLSNILNKLDLANRSQLVRFAYENGYRLPEPK
>NC_019753.1|WP_015204145.1|3599277_3600702_-|NADP-dependent-isocitrate-dehydrogenase
MYEKITPPDTGSRITFQNGEPIVPDNPIIPFLRGDGTGVDIWPAAQKVFDAAVQTAYGDKRRISWFKVYAGDEACEKYGTYQYLPEDTLNAIKEFGIAIKGPLTTPVGGGIRSLNVALRQIHDLYACVRPCKYYQGTPSPHKTPEKLDVIVYRENTEDIYLGIEWRQGSEMANKIIHLLNTELIPATPEHGKKQIPLDSGIGIKPISRTGSQRLVRRAMQHALRLPKNKQMVTLVHKGNIMKYTEGAFRDWGYELATTEFRNQCVTERESWILSNKEKNPDITTAENASEIEPGYDSLTEEKQAAICREVENVLNSIWETHGNGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDNCAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEFMGWQEAADLIKQGIGKAISNREVTYDLARMMEPPVEPPLKCSEFAEAIIKNFG
>NC_019753.1|WP_041226729.1|3598059_3599169_+|YjgP/YjgQ-family-permease
MDRYIAIELLMPFLFGVGAFSSLGVAIGSLFDLVRQVAESGLLIAIAVKVLLLKMPEFIVYAFPMSTLLTCLMTYSRFSSDSEIIALRSCGISIYRLILPAIVLSFMVTGMTFLFNELVVPAANYEASTTLSQALKKDQLTLKEENIFYPEYREEQVNGAKTKTLARLFYADKFDGKQMKNLTILDWSRKGLNQIVTADSATWNTQENTWDFFNGSIYIVAPDASYRNILKFEHQKLRLSRAPLDLASKGRDYGEMNIAQSLEYLKILNMSGDDKKTTKLKVRIQQKISLPFVCLVFGIVGAALGIRPQRTGRATSFGVSVIVIFSYYLLSFISGALGQVSVLSPFLAAWLPNIFGLTAGGVMVLRVAR
>NC_019753.1|WP_015204143.1|3597178_3597907_+|LPS-export-ABC-transporter-ATP-binding-protein
MKIFLENVHKSYNKRQIVNKVSLSVSQGEIVGLLGPNGAGKTTTFYMATGLEKPDQGRVRLDALDITNLPMHERARLGIGYLAQEPSIFRHLSVLDNILLVLEQTNVPRREWGRRISSLIQEFRLEKVVYTKGNQVSGGERRRTEIARALAAGRDGPKFLLLDEPFAGVDPIAVSEIQKIIAQLRDRRMGILITDHNVRETLAITDRGYIMRDGQILASGSAEELYANPLVRQYYLGQNFQR
>NC_019753.1|WP_051035459.1|3596660_3597107_+|OstA-family-protein
MISSHKLIDSLKRQLGLALIAPIAVAGALVPLQLQNAQAQTSQDNRPLSVRADVQEYNSKTGVVTARGNVQVLYPSRQIQGTAAQAQYFSRERRIVMSGNVYILQQGNSLRGETITYLIDEGRFVALPKSNKQVESVYIVSEPNNPQR
>NC_019753.1|WP_015204152.1|3610361_3611480_+|alpha/beta-hydrolase
MVLMPLTFLMVWLAGLLSIGILGGGVYILYEWYEGDLVGYSYLLGGVALVLWSFGGRFIIPLLFHRPGNDEPSFMRTGSVQRIQRPDGSELHVEFYGPEDGQPIIFSHGWGPNSTVWYYAKKQLSDRFRVIVWDLPGLGKSKRPKNNDYSLEKYARDLEAVVSIAGDKPVILLGHSMGGMITLTFSRLFPELLGSRVAGLILVDTSYINPVKTCIFNGLVTALQKPVLEPILYLTIFLSPIFWAMTWLSYFNGSLYISVELSGFTGKETRGQLNFAALLSALGEPGVLARGTLAMFKLEETATLKNINVPVLVVTGKSDIAVVPETSARMQAEIPNAELVTLKPGGHMALMERNEQFSEAVSSFSSAIASKA
>NC_019753.1|WP_015204153.1|3611512_3611698_+|hypothetical-protein
MQIKDMTTDEFKDLIRETIVETLEEYLGDTDEGKEVKEEVKQKLLDIRKRREAGHRREIYG
>NC_019753.1|WP_015204154.1|3611963_3612962_+|WD40-repeat-domain-containing-protein
MHKLKHKWILGGAILLTIWGGGWIYSQIRFGANPISVITSPSLLKTTLTGHSDSVNSVAISSDGQTLASGSEDGTIKIWNLSTGQEIRTLTGHSEFVKSVAISSDGQTLASGSEDNTIKIWNLSTGQEIRTLTGHSEFVNSVAISRDGQTLASGSGDNTIKIWNLSTGQVRHTLTRHSFPVKSVAISSDGQTLASGSEDNTIKIWNLSTGQEIRTLTGHSEFVNSVAISRDGQTLASGSGDNTIKIWNLSTGQEIRTLTGHSFPVRSVAISSDGQTLASGSEDNTIKIWNLSTGQEIRTLMGHSGWVYSIAISRDGQTLVSGSNDKTIKIWR
>NC_019753.1|WP_015204155.1|3613060_3613228_-|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MKTKLLTAIVHKEEDLYVAECPEIGTVDQGETIEEALANLKEATQLYLEATSVLK
>NC_019753.1|WP_015204156.1|3613296_3613521_-|hypothetical-protein
MQPNFEQFSNKELIQYALTHRDELEPLRVLYRRRTPDEQATWYEPMIGEDGTPIEENIQLAQEAIHQRLEKHKK
>NC_019753.1|WP_015204157.1|3613504_3613696_-|hypothetical-protein
MQPTNAQAQACLRVCQMLSNSYRNIELFRFDDETGIVFILAGEDIQIIIPPNGRWRFLDATEF
>NC_019753.1|WP_041226734.1|3614058_3617088_+|excinuclease-ABC-subunit-UvrA
MSNLTTSPNGHHPSNKDENTIRIRGARQHNLKNIDLELPRDRLIVFTGVSGSGKSSLAFDTIFAEGQRRYVESLSAYARQFLGQLNKPDVDAIEGLSPAISIDQKSTSHNPRSTVGTVTEIYDYLRLLFGRAGVPHCPICDRSIVPQTIDEMCDRIMELPDRTRFQVLAPVVRGKKGTHAKLLSSLASEGFVRVRVDGVVYELSENIELDKNYTHTIEIVVDRLVKKPGIQERLTDSLTTCLRHANGIAVIDVIPDTSVQTDSSPNTRRYSENSTDFLKYQESSENKVTDNNQATPTNNDNDYQEITKEIVFSENFACPEHGAVMDELSPRLFSFNSPYGACPSCHGLGNLRTISPDLIVPDPEASVYSAIVPWAEKDNSYYLGLLYSVGQAYHFELQTIWKNLTAEQQHVILHGADKPIWMQERNDHRRYAGAIAILKRQYDDGSELQKQKLEQYLVDQPCEVCQGKRLKPEALSVRLGQHRILDLTSVSIGECRQRIDELKLSDRQAQIADLVLREIKARLQFLLDVGLDYLTLDRPAMTLSGGEAQRIRLATQIGAGLTGVLYVLDEPSIGLHQRDNGRLLNTLTKLRNLGNTLIVVEHDEETIRAADHLVDIGPGAGIHGGRIISQGNLDTLLQAEDSLTGAYLSGRKVINTPAERRDGNKRSLVIKNAYRNNLKNVDVEIPLGKLVSVTGVSGSGKSTLINELLYPALQHNLTRKVPFPKDLEKIDGLNAIDKVIVIDQSPIGRTPRSNPVTYTGIFDPIREVFCQTIEAKARGYKPGQFSFNVKGGRCEACSGQGVNVIEMNFLPDVYVQCEICKGDRYNRETLQVKYKNKSIADVLNMTVEEALEFFINIPRAASKLQTLADVGLGYIRLGQTAPTLSGGEAQRVKLATELSRRATGKTLYLIDEPTTGLSFYDVHKLLDVLQRLVDKGNSILVIEHNLDVIRCADWVIDLGPEGGDKGGEIIAVGTPEEVAKNNRSYTGQYLKQVLQQHPPTLVHNSDLKQ
>NC_019753.1|WP_015204159.1|3617361_3617556_-|hypothetical-protein
MIISTQNEIQQINLNGNLLTNWKGSLASDFLNHMGKEGWEMSGVWRNEKAVGGFGVFLYFKRPY
>NC_019753.1|WP_015204160.1|3617682_3618096_+|hypothetical-protein
MRDPLRRLKNLPWRALLQVSVLTNLIVLVLDFLIWREYQRSPVVRQALIILYTPPLEIITTLTVAVGVGALAVYLLERFYPQIRLEANTLWALVPCLALIIFLKSLLPLPSILLSFNEVQVMAIIIGIFWKSQRYWR
>NC_019753.1|WP_015204161.1|3618147_3618600_+|GNAT-family-N-acetyltransferase
MKIIKVTPENFNEWLDLTLKLWQDVSRAEMEEGLKNLLKSEREAGFIAINDDEKTMGFINLSLRSDYVAGATSSPVAYIEGIYAKDEYRHQGVGKYLIDFASQWALEHGCTQLASDALIDNTVSYEFHTKVGFQEVDRVVTFIKQIVISS

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Crispr_ID: NC_019753_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_16

4414992-4415076

Orphan

Consensus_repeat	Method
TAGCATTAGTTAGCGTAACCAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019753_16

>merge|NC_019753|16|4414992-4415076|CRISPRCasFinder
TAGCATTAGTTAGCGTAACCAATTCTCCCCCCTTGTTAACGGAAGCTAGGGGAAATCATTTGTAGCATTAATTAGCGTAACCAAT

>NC_019753|16|14|4414992-4415076|CRISPRCasFinder
TAGCATTAGTTAGCGTAACCAAT	TCTCCCCCCTTGTTAACGGAAGCTAGGGGAAATCATTTG
TAGCATTAATTAGCGTAACCAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_157462353.1\|4419657_4419798_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204809.1\|4404734_4406192_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_019753.1\|WP_015204821.1\|4416970_4417192_+\|addiction-module-toxin,-HicA-family	unknown	unknown	gnl\|CDD\|377942
NC_019753.1\|WP_041226124.1\|4411206_4411860_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227364
NC_019753.1\|WP_157462354.1\|4425111_4425723_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204819.1\|4415097_4416714_+\|cyclic-peptide-export-ABC-transporter	unknown	unknown	gnl\|CDD\|226968
NC_019753.1\|WP_041226125.1\|4416767_4416974_+\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|224514
NC_019753.1\|WP_015204813.1\|4409320_4409662_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319771
NC_019753.1\|WP_015204817.1\|4412383_4413658_+\|proton-extrusion-protein-PcxA	unknown	unknown	gnl\|CDD\|235046
NC_019753.1\|WP_157462352.1\|4419480_4419657_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204812.1\|4408305_4409175_+\|ribosome-biogenesis-GTPase-YlqF	unknown	unknown	gnl\|CDD\|236570
NC_019753.1\|WP_051035410.1\|4413682_4414879_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|133005
NC_019753.1\|WP_015204811.1\|4407745_4408159_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_019753.1\|WP_015204825.1\|4419865_4422076_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_041226126.1\|4417744_4417963_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_041226829.1\|4410653_4411091_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380392
NC_019753.1\|WP_041226828.1\|4409740_4410508_+\|cysteine-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238245
NC_019753.1\|WP_015204810.1\|4406361_4407564_-\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NC_019753.1\|WP_015204827.1\|4423700_4424942_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224117
NC_019753.1\|WP_015204826.1\|4422325_4423687_+\|proton-extrusion-protein-PcxA	unknown	unknown	gnl\|CDD\|235046

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015204809.1\|4404734_4406192_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.67398e-60
NC_019753.1\|WP_015204821.1\|4416970_4417192_+\|addiction-module-toxin,-HicA-family	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	1.47939e-14
NC_019753.1\|WP_041226124.1\|4411206_4411860_+\|hypothetical-protein	gnl\|CDD\|227364	COG5031, COQ4, Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism].	1.65092e-78
NC_019753.1\|WP_015204819.1\|4415097_4416714_+\|cyclic-peptide-export-ABC-transporter	gnl\|CDD\|226968	COG4615, PvdE, ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism].	3.06219e-133
NC_019753.1\|WP_041226125.1\|4416767_4416974_+\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|224514	COG1598, COG1598, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	1.1393e-17
NC_019753.1\|WP_015204813.1\|4409320_4409662_+\|hypothetical-protein	gnl\|CDD\|319771	cd02076, P-type_ATPase_H, plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases. This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0.00501198
NC_019753.1\|WP_015204817.1\|4412383_4413658_+\|proton-extrusion-protein-PcxA	gnl\|CDD\|235046	PRK02507, PRK02507, proton extrusion protein PcxA; Provisional.	0
NC_019753.1\|WP_015204812.1\|4408305_4409175_+\|ribosome-biogenesis-GTPase-YlqF	gnl\|CDD\|236570	PRK09563, rbgA, GTPase YlqF; Reviewed.	2.1747e-144
NC_019753.1\|WP_051035410.1\|4413682_4414879_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	6.8013e-51
NC_019753.1\|WP_015204811.1\|4407745_4408159_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.42211e-27
NC_019753.1\|WP_041226829.1\|4410653_4411091_+\|cupin-domain-containing-protein	gnl\|CDD\|380392	cd06987, cupin_MAE_RS03005, Microcystis aeruginosa MAE_RS03005 and related proteins, cupin domain. This family includes bacterial and some eukaryotic proteins homologous to MAE_RS03005, a Microcystis aeruginosa protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	6.25497e-72
NC_019753.1\|WP_041226828.1\|4409740_4410508_+\|cysteine-hydrolase-family-protein	gnl\|CDD\|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	1.82474e-39
NC_019753.1\|WP_015204810.1\|4406361_4407564_-\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NC_019753.1\|WP_015204827.1\|4423700_4424942_-\|hypothetical-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	0.000652843
NC_019753.1\|WP_015204826.1\|4422325_4423687_+\|proton-extrusion-protein-PcxA	gnl\|CDD\|235046	PRK02507, PRK02507, proton extrusion protein PcxA; Provisional.	0

>NC_019753.1|WP_051035410.1|4413682_4414879_-|tetratricopeptide-repeat-protein
MNLSLCMIVKNEELLLPQCLNSVKNVVNEMVVLDTGSSDRTPEIAKGLGAKVYHFPWCNDFSAARNESLKYVQGEWVLVLDADEVLIPEIVPQIQQVIKSDRHILINLVRQEVGASQSPYSLVSRLFRNHPDVRFSRPYHAMVDDHVQALLRIESQWQVGYLPDVAMLHYGYQPGAIASRDKLNKARTTMEGFLATHPNEPYVCSKLGGLYLDLGEVNQAIELLQRGLTANTLDVSVLYELHYHLGNAYIQLPDINQAVLHYQTAIQQPVLPILKLDAYNNLGNLLKAAGDLTNARKAYETALQIDPNFTTGYYNLGMTLRAMGFFEDAIALYRKAIEINPNYAEAYQNLGVVMLQIGNVAESIAAFRNAIALHQQHNPEEAQRLLNDPLLSELLANN
>NC_019753.1|WP_015204817.1|4412383_4413658_+|proton-extrusion-protein-PcxA
MRATFSWDNTDELRKKVGKYLRATNKWFFETPERSLEQAYNAALIIRSIEEEYLGDRNSNPAEQGKNVKAYLKADIDKNLGIIKLRLAEFKLSRSILTISNPVILEKLRFIDEVLVKYQQKNSNSVALIPVTEASPITLQPDKIKADQHGIDSKKFEKPTEKTGALPRSIGRTLNRIKTELDPESETAVVRDFRKSRNRTKVTIRFILLLILIPVLTQQLSKEFLVKPIIAHVKTENNPQIFLNVEMQEEAFRELENFEASLKFQNLINQAPKFSSEEMEERVKNKAIKIAEEFRDKSRDAVSNIFADFLGLAAFGVVIATSKREIVTVKFFMDEIVYGLSDSAKAFIIILCTDIFVGFHSPHGWEVILEGFAGHLGLAANQSLISLFIATVPVILDTFFKYWIFRYLSRVSPSAVATLRNMNE
>NC_019753.1|WP_041226124.1|4411206_4411860_+|hypothetical-protein
MQTLENVAQQWQTSVVESIINMVNAEDGDFGAIAKLSQAVNDVSSINKMIEFLCNHPQCKRAFEERPRLGNVDLQLLHQLPENTLGYAYANHMIKNNLTPLQGNFGDSNYQFLAAHLTETHDIWHIVTGCDTNITGEIKLEAFYVAQLYASRFWLALLTKNLLKAVVFDIEVSSKYMDALTEGWLMAKQAKPLFGIQWNTLWETSLEEVRNSLTISN
>NC_019753.1|WP_041226829.1|4410653_4411091_+|cupin-domain-containing-protein
MIADIKSPKDYQAFRISPNDTNRLAIIFDPTTDDISFTVCVEIFDTGGKTPPNRHQFATEMFFILKGEGRVDCDGRTALIKAGDSILVPATGMHIIENTGKDRLYALCVMVPNEDFAELIRRGAPVELDEEDLAVLSQANTPIFI
>NC_019753.1|WP_041226828.1|4409740_4410508_+|cysteine-hydrolase-family-protein
MNRPLYNLGVPPNAWKVNDAIADITRVPIEPRPINLTTETKTLRLDLAKAAILVIDMQNDFCHPDGWLAYIGVDVTPARTPINPINNLLPVLRNFNVPLIWLNWGNRPDLLNISAGLRHVYNPTGKGIGLGDRLPKNDAPVLTVNSWAAAVIDELEQKPTDIRVDKYRMSGFWDTPLDSILRNLGKTTLFFAGVNVDQCVMATLQDANFLGYDCILLKDCTATTSPEFCLKATLYNVNQCFGFVSDSQTLINAVK
>NC_019753.1|WP_015204813.1|4409320_4409662_+|hypothetical-protein
MRFLNKLMGLALILTGIYFLGQNIIFTTHTSRYWWRDIPAGGSVICILGGILILLLAGREARDTGWILVGLGIVLVFLSGGVLLQPTSLWTFFLSFFSMIGGYKLLTRGRLDF
>NC_019753.1|WP_015204812.1|4408305_4409175_+|ribosome-biogenesis-GTPase-YlqF
MSTPPIQWYPGHIAKAERSLKEQLKRVDVVLEVRDARIPLATRHPQVQEWIASKTKVLVLNRVDMISPAVRQLWTQWFLQHGEKPYFTNAQQGEGVVAISKAAAEAGVEVNKKRSDRGLLPRPVRAVVIGFPNVGKSALINRLLKKRVVESARRAGVTKQLRWVRISDQIELLDAPGIIPWKLDDQDAAFKLAICDDIGEASYDNQRVAAALVDLLNDLIVTDPDLLPQSPLKSRYELDSAPFSGEEYLQNLADQRNKGDIERTARQMLNDFRKGLFGAIPLDLPPQPQ
>NC_019753.1|WP_015204811.1|4407745_4408159_+|universal-stress-protein
MFKTVLFPVDQSREAREAAEVVVNIVQKYSSHLVLLSVVETPTSEEEVPESSPMASPEAIAELLKTAQNLFSEQGIQAQTIEREGKPAFIICDVADEIDADLIVMGCRGLGLTEEGASESVTNRVINLSPCPVLIVP
>NC_019753.1|WP_015204810.1|4406361_4407564_-|phosphoglycerate-kinase
MSKKSVANLSASDLSGKRVLVRVDFNVPLDDAGNITDDTRIRAALPTIQDLTGKGAKVILTSHFGRPKGVDDKLRLTPVAKRLSELLGQDVIKCDDCIGDEVTSSVGAMQDGQVALLENVRFYKEEEKNDPEFAKKLASVADLYVNDAFGTAHRAHASTEGVTHYLSPSVAGYLIEKELKYLQSAIESPQRPLAAIIGGSKVSSKIGVIETLLDKCDKLLLGGGMIFTFYKARGLNVGKSLVEEDKLELARSLEAKAKERGVQLLLPTDVVVADNFAADANSQTVSIENIPDGWMGLDIGPDSVKVFQEALADCKSVIWNGPMGVFEFDKFAAGTFAIAHTLAEIGKQGATTIIGGGDSVAAVEKVGLADQMSHISTGGGASLELLEGKELPGIAALDEA
>NC_019753.1|WP_015204809.1|4404734_4406192_-|serine/threonine-protein-kinase
MVENTLRDRYQIIQHLASRRFCEIYLAKDEDLPGKPVCVIKQLKPKNLDPLLWSTAKRFFKAEAEALYRLGKHDKIPQLLAQFEEGANSYIVQEFIEGKELSEELIAGQQWSEEQVIVFCREVLEILDFLHQHHIIHRDIKPSNLIRRTKDNKITLIDFGAVKQKTPDFGVNVDQGGWTVAIGTEGYMPPEQANGNPQYNSDIYALGVICIQALTGVAPQKDNNTNELIWQNQAKISPKFANVLNKIVHTDYNQRYQSAAVALQEIKKLSNIDIQRKENKSSFINVLPVILLTISLLTFVSTLLFTQWRITEINKNLNNPTSTELPLAKSNNFVSYENVNAGIKIKYPENWQKQDVENPFTGEIVLFTSPSNPTNKFAPKLSIRTENLSRQSISLEDYTNSSLKEIQKYLENANITDSSSTTLGGIPAHRVVYNGVDGESRIIENLEVWAVFNQKVYIVSYTATPEEYPNYLESVEKMINFFEIF
>NC_019753.1|WP_015204819.1|4415097_4416714_+|cyclic-peptide-export-ABC-transporter
MNLLQLLLRTSWVSVTSAIIAALISGVSSTGLIALINLSLNNSKLPITSLAWAFAACCLLLLISTAASLIAIAYLSQQVIFKLWIDLNRRILASPLRRIEEIGSPRLLATLTEDIEAISQAAIAISNISVNVAAIVACLIYLCWLSIPVFLSMLACLLLGIFSYQLIATSGNNALKLAREQQDKLFHHFQTTTQGIKELKLHQQRREEFFLKDLQTTATSFKKYRFHGMTIFAIAGSWGLVLFFIPLGFIVFGLPQITTISTSVLSGYALTILFIILPLRNILDSLPQLITANISLAKVESLGLSLAAETNQPNLNSPIQPSVSWKRLELIGVTHAYRGEKDNTFILGAINLNFYPGEIVFIVGGNGSGKSTLVKLITGLYIPETGEIKFDNVAITEHQREWYRQQFSVVFSDFYLFENLLGLDSINLDTTTQEYLIKLQLDHKVEVKDGMLSTTALSQGQRKRLALLTAYLENRPIYIFDEWASDQDPVFKEIFYTQLLPELREKGKTVIVVSHDDRYFHLADRVIKLDYGQVQHDN
>NC_019753.1|WP_041226125.1|4416767_4416974_+|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MRQVIMYRDEDGYWIVECPSLKGCVSQGKTKQEAISNIKEAITGYIAALEADNLPVPEENFETFLVVV
>NC_019753.1|WP_015204821.1|4416970_4417192_+|addiction-module-toxin,-HicA-family
MSKLPSISGIDCVKALQKVGFYQKRRESSHIILRRDDPFAQVVVPDHQELAKGTLRAIIRDADLTIEEFIALL
>NC_019753.1|WP_041226126.1|4417744_4417963_+|hypothetical-protein
MTNYKFHDELSLAETAENLGKEAIKLGLIPSFVVRFFPDSRQFYIPDETKSEPLTPEEAYLQLKKLVEEAAK
>NC_019753.1|WP_157462352.1|4419480_4419657_+|hypothetical-protein
MTYLSNLLVLYVQLLESHIFAIADERFFDNPLVTTDPHIRFYAGAPLMTPSGSAIGSI
>NC_019753.1|WP_157462353.1|4419657_4419798_+|hypothetical-protein
MLDKAPKKLNDEQLEMLKILSRMVMRELEKRKQISELKNQDLRLKK
>NC_019753.1|WP_015204825.1|4419865_4422076_-|hypothetical-protein
MVSDSIWITGTTGSGRTNRLVTQFCDWVELQAGQPSYGRNKRMFIAAAKVSGRFRQIPKILVFAANDDSRRDLADRLTSAIAGRYPVIAKTPLGFFQDEVMLFWPLLIQRLNLRAQFPLRLRPETEQELATRLWRADLDAANIQTLGVGEYRFVRRTLDLLQLAATSGTPPEEISSILGQGLATDSVTDVTDREENLDRSFSLMGELLLGWRGWCLERGLLSYGLICELYWRYLLPDASYQQHLSLRYQAVLADDVDDYPAIARDLFEVLLNQGAVGAFTYNPDGKVRLGLNADPEYMAGLKARCQIESLTQERNCLADSLADSVVELVKEPGWLISLPSSIGSIQTTARSQLLRKTAEVIIQAVQNGEVQPEEIVVIAPGLDAIARYTLTEILTSKGIAVEAMGDQRPLISSPVIRALLTMLALVYPGLGRLVDRDAVAEMLVVLSRKDGEQGNRGDLDDQIPQPSVFSPYIDPVRAGLIVDHCYAPDPEQPRLLPVTTFTRWDRLGHKATTAYEQILEWVEKQRSQQEQRLIPNAITLLDRAIQQFLGNGSNLPYDQLSALRELMETAQHFWEVDGRLRQSEKIDTPPHTTIAQFIVLLRKGTITATPYPVKRLKSDRAVTLATIFQYRSRRKFHKWQFWLDASSPLWLSGGAATLYGANLFLKDWSRNPWTQADSEIADQERLERILRDLLGRAGERVYLCHSDLAVNGQEQAGGLSSLVNASFPLSVELTLT
>NC_019753.1|WP_015204826.1|4422325_4423687_+|proton-extrusion-protein-PcxA
MKTFSFNTLNSYIRQANQWFNTTPERSLDQAYQAALMIKAIEDEHFGGNKITAQSSTYGSNVASYFQTDLKKYLNIAKIRLTEFKASRYFKNLYQQQPPLKQAERIVDSREVYVENKEKSLVIIEKLKFIDEVLGRYTLDKDIKPSYSVVSIPKTNITSVDEEKIAHTKLNYPGVPGGKQEISDVETISDKTGILPRSILGTFKRLRRDLDPQAENEVIKNFRTSKAKTLISIKFILLLILIPLLTQQVTKTFIVSPIVDQVRESSNSGIFLNIDLEEEAFTELERFEKELKFKNLIGLVPKISSEEIEEQIKEKADKLQKEFQGKSSNAVKNVFADIFSLVAFATVILTSRQDILVLKSFIDDMIYGLSDSAKAFIIILFTDIFVGFHSPHGWEVILETIAEHLGLPANREFNFLFIATFPVILDTVFKYWIFRYLNRISPSAVATYRNMNE
>NC_019753.1|WP_015204827.1|4423700_4424942_-|hypothetical-protein
MIKQSWLELSEYAALAASGLGTLAAVLSNQALYAATPLTIALSLNLVNRRHIQAQARQATTLEIANLHTVLNQQIEALPPPPEPVNLTAIERKISHVSSQLKYLNQQINLKAEAPEVLELAERVALLTKQFNNRAEKQELAKLVQRIALLTQQFNGRAEKQEILQLKAQLNTLKEQFQSRRETRTIFEVTEKLELLTKRFNERIELKEILSIREKLELLAKLFPYRIEPQKIEQIRQQVESLSQRFEQRIKPNEISEIKQQLNGVDLELNLLREQVNNCQKTEKIELLIKRLNAVSQKFNNRPEKQAIAQMTQNLEIVTRQVNGIVLSESVDLTEIKDLLVNQSMQLHYLKQQLNHLTYEFHNRPEKQIMAHLQQEIATPITESACEWSGIRKQIKQGIVETRNGASLHGNVY
>NC_019753.1|WP_157462354.1|4425111_4425723_-|hypothetical-protein
MNSQNKQPQKPQVNRSPSVSMTVLPMPKQHQYKTPALPKVTAPNLTQHRIRANPAMAITVLKEIEQKVVGWQQQLQQTLKKIQDVYSEGPIIDGWIESTSQNQSISVKDRHQASMPPMMDYVTEIVSQPDGKFTVADYRLCGLDADGMLWERPCPCEQVKSVSMAIARYHKLCQLLNQKQDLENRLTQLTETLMVLQDHLSTG

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Crispr_ID: NC_019753_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_17

4510783-4510881

Orphan

Consensus_repeat	Method
ATTAATAATATTCCCAGTAGTAATATTTCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_019753_17

>merge|NC_019753|17|4510783-4510881|CRISPRCasFinder
ATTAATAATATTCCCAGTAGTAATATTTCAACAACAAATCCACCTTCTCCTCAATCTTCCCCAACACCAATTAATAATATTCCCAGTAGTAATACTTCA

>NC_019753|17|15|4510783-4510881|CRISPRCasFinder
ATTAATAATATTCCCAGTAGTAATATTTCA	ACAACAAATCCACCTTCTCCTCAATCTTCCCCAACACCA
ATTAATAATATTCCCAGTAGTAATACTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015204884.1\|4499963_4500710_-\|creatininase-family-protein	unknown	unknown	gnl\|CDD\|376872
NC_019753.1\|WP_015204896.1\|4514333_4514723_-\|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl\|CDD\|214358
NC_019753.1\|WP_015204885.1\|4500992_4501745_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_019753.1\|WP_015204889.1\|4506316_4506643_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204886.1\|4501814_4503155_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|274368
NC_019753.1\|WP_157462469.1\|4503365_4503950_+\|phosphate-signaling-complex-protein-PhoU	unknown	unknown	gnl\|CDD\|223776
NC_019753.1\|WP_015204892.1\|4509112_4509433_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204883.1\|4498996_4499929_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119323
NC_019753.1\|WP_015204899.1\|4516448_4516874_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NC_019753.1\|WP_015204895.1\|4512822_4514268_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015204904.1\|4518983_4521443_+\|glycoside-hydrolase-family-31-protein	unknown	unknown	gnl\|CDD\|269881
NC_019753.1\|WP_015204890.1\|4506663_4507203_+\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198397
NC_019753.1\|WP_015204888.1\|4504270_4506046_+\|iron-uptake-porin	unknown	unknown	gnl\|CDD\|335962
NC_019753.1\|WP_015204891.1\|4507359_4509111_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_019753.1\|WP_015204898.1\|4515615_4516332_-\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|177051
NC_019753.1\|WP_015204900.1\|4516880_4517531_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NC_019753.1\|WP_015204901.1\|4517527_4517752_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|236066
NC_019753.1\|WP_015204897.1\|4514781_4515351_-\|50S-ribosomal-protein-L10	unknown	unknown	gnl\|CDD\|234632
NC_019753.1\|WP_015204903.1\|4518455_4518818_-\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|177023
NC_019753.1\|WP_015204894.1\|4511397_4512432_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015204884.1\|4499963_4500710_-\|creatininase-family-protein	gnl\|CDD\|376872	pfam02633, Creatininase, Creatinine amidohydrolase. Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyzes the hydrolysis of creatinine to creatine.	1.82649e-85
NC_019753.1\|WP_015204896.1\|4514333_4514723_-\|50S-ribosomal-protein-L7/L12	gnl\|CDD\|214358	CHL00083, rpl12, ribosomal protein L12.	1.34814e-56
NC_019753.1\|WP_015204885.1\|4500992_4501745_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.55067e-92
NC_019753.1\|WP_015204886.1\|4501814_4503155_+\|PAS-domain-containing-protein	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	1.91427e-43
NC_019753.1\|WP_157462469.1\|4503365_4503950_+\|phosphate-signaling-complex-protein-PhoU	gnl\|CDD\|223776	COG0704, PhoU, Phosphate uptake regulator [Inorganic ion transport and metabolism].	6.815e-47
NC_019753.1\|WP_015204883.1\|4498996_4499929_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	1.61069e-59
NC_019753.1\|WP_015204899.1\|4516448_4516874_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	7.8532e-97
NC_019753.1\|WP_015204900.1\|4516880_4517531_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	3.43042e-83
NC_019753.1\|WP_015204904.1\|4518983_4521443_+\|glycoside-hydrolase-family-31-protein	gnl\|CDD\|269881	cd06595, GH31_u1, glycosyl hydrolase family 31 (GH31); uncharacterized subgroup. This family represents an uncharacterized GH31 enzyme subgroup found in bacteria and eukaryotes. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.	1.40566e-104
NC_019753.1\|WP_015204890.1\|4506663_4507203_+\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198397	cd10450, GIY-YIG_AtGrxS16_like, GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins. The family includes CAX-interacting protein-1 (CXIP1)-like proteins and iron-sulfur cluster assembly proteins, both of which contain a GIY-YIG domain that shows statistically significant similarity to the N-terminal catalytic domains of GIY-YIG family of intron-encoded homing endonuclease I-TevI and catalytic GIY-YIG domain of nucleotide excision repair endonuclease UvrC. CAXIP1 is a novel PICOT (protein kinase C-interacting cousin of thioredoxin) domain-containing Arabidopsis protein that activates H+/Ca2+ exchanger CAX1, and its homolog CAX4, but not CAX2 or CAX3. Iron-sulfur cluster assembly proteins in this family also contain a C-terminal NifU-like domain that corresponds to a common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.	3.31004e-33
NC_019753.1\|WP_015204888.1\|4504270_4506046_+\|iron-uptake-porin	gnl\|CDD\|335962	pfam04966, OprB, Carbohydrate-selective porin, OprB family.	7.01303e-37
NC_019753.1\|WP_015204891.1\|4507359_4509111_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.90041e-79
NC_019753.1\|WP_015204898.1\|4515615_4516332_-\|50S-ribosomal-protein-L1	gnl\|CDD\|177051	CHL00129, rpl1, ribosomal protein L1; Reviewed.	6.05614e-147
NC_019753.1\|WP_015204901.1\|4517527_4517752_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|236066	PRK07597, secE, preprotein translocase subunit SecE; Reviewed.	2.9937e-12
NC_019753.1\|WP_015204897.1\|4514781_4515351_-\|50S-ribosomal-protein-L10	gnl\|CDD\|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	2.12437e-63
NC_019753.1\|WP_015204903.1\|4518455_4518818_-\|50S-ribosomal-protein-L19	gnl\|CDD\|177023	CHL00084, rpl19, ribosomal protein L19.	3.42171e-61
NC_019753.1\|WP_015204894.1\|4511397_4512432_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	9.6952e-32

>NC_019753.1|WP_015204892.1|4509112_4509433_-|hypothetical-protein
MNQSEFYNRAIALYLDSLDEHHGLLLQYCQLSIGLVIVKSLNKDYKVENCLNIKYDSAFIGNDLSALTIQYFEEKALALGIKKVVWESLEVDSILDWCRKPENLAR
>NC_019753.1|WP_015204891.1|4507359_4509111_+|serine/threonine-protein-kinase
MALTLLNNRYRTIQDLGSGGFGNTFLAEDTHMPSARRCVIKQLKPVTNNPQMYQQVQARFQREAAVLEALGEVSKQIPQLYAYFSEAGQFYLVQEWVDGDTLTKIIERQGALPEKTVRDILVSLLSVLEYVHSKQMVHRDIKPDNIIVRDRDRQPVLIDFGAVKEAMGSTNQTMVIGTPGFMPSEQAAGQPVYATDLYSLGVTAIYLLTGKMPQDLPTDPGTGMIMWHGSAPGVSPSLASVLDKTIQPHPRDRFSTAKEMLNALQKSVNSPVSNPLGTQATVAVSPVGRQYQPSPQNTPVVTPSQPNIITSNESRWLKPWVLAILIICGFVGSAIAFNRIFNKNTDPTPQVASSPPSQPTNRNTEETNESDSSNSQKEIPPVISESSSPLPSKSPKPSILSQPQATEQPPVIIASPSPIVERSPSPVIKSDNSQNQNRSDQVPAFPTGTPISNVQETLGKPRINARGVWGNTRAVVYKLKPNQIDLGYLYDRNTENIRQTEVSFSNSVDPQLMLNTLDGLLEGGATPEIKQGLLRVQQGRNNSFTFTQGSLKGQIVQQDCGFIYISIWEADLHNFNVSSSRKC
>NC_019753.1|WP_015204890.1|4506663_4507203_+|GIY-YIG-nuclease-family-protein
MTNSTEIPSIASLEYIPYIDETGNLPESLQGKIGVYAIFDNDKVLQLVAYSRDVYLSLKQHLVRQPKKCYWLKYQTIERPNRTILESIQNSWIEENGYIPVGNKTAQAEWNDPIDTKSAMTEEEQENFAKQDEVGQIKLLKKVARRVEETILSEIKTRGVQTEIRFNPKLKESGLLDLK
>NC_019753.1|WP_015204889.1|4506316_4506643_+|hypothetical-protein
MAQLKIINNFDTSFTLEQDAKETLFNLLKGESFLKQLTDNLQSQAVEFTELIFQPVPYSEATPKGMPAEYEVYHNSPDYIIINVPPNFMFQSKIFKPSRLCAIYRKIG
>NC_019753.1|WP_015204888.1|4504270_4506046_+|iron-uptake-porin
MSRIFWNTFKVAPAIAASLLIASNSLAAESVTEQTATVPTEETTIAQTSPVSSEVPADTNNIEQLQRYNSEISGEDGMSQVTNVSQFRDVQPSDWAYEALSRVVQTYGCLQGYPDGTYRGNRALSRYEFAAGLNACLRQIEALIGRTPTPGGGGVSDSDLQTLRRLTEEFRTELTTLGTRVNNLEGRTAFIEQRQFSTTTKLVGEVVIAASEVFGKSGPTTNGQTADNVEPILSNRVRLNLDTSFTGKDRLRTRLQARNTVPFSGALTGTNMTRLGFDGDNQNDIEIHRLEYRFPVTPNANIFLSATGTEYNDIIYTFNPLLESAASGSISRFGRFNPIYRTSAEGASAVLDYKLSKQVGLSLGYAVPRNIANRPETDTPTQPGLSLFNGSYAALAQLAFRPSNAVGLGLTYVRSFSNPPPNPNPSGLGAIGAIGVSSGTGSAFANQPFGANTPTTTNQYGVEASFRLSPRFVVSGWAGYTQAEAAGDTGIARLGSSADIWNYAVTLALPDFGKQGNVLGFVFGMPPKVTQNEVTTRQDNRGTSYHVEGFYRYRLTDNVEITPGVFAILNPQHNDNNDTLYVGTLRTTFRF
>NC_019753.1|WP_157462469.1|4503365_4503950_+|phosphate-signaling-complex-protein-PhoU
MGALVENSFRLSHQALFASNLAAAKKIPILDKQVDRFYHQIELDCAALMTLEAPVAQDLRMLNAFIQMVRDLERIGDYAKNLGEIAIKLFPYSPHPCLSEIELMSHQAQAMLSASLAALADMDAVAGHRVKQLDDVVDDAYEKIYQTLAYQKDIKGVVEPILLLCLTIRHLERMADHATNIGQRVKYIVTGNFS
>NC_019753.1|WP_015204886.1|4501814_4503155_+|PAS-domain-containing-protein
MTVIAFLLGLAIGIGLWFWRQTVWHRQMQQMLDLLETGGAEGTSLPIASRLRMGISLVKQQRQQQEILLQSWRQLLELAPIGYLHIDEDNQLIWCNHQARQLLQIYKWESAQARLLLEVVRSFELDQLIEETRQRQQKCELEWLFHPAYKEAAQFNQVRSHLSPEPQIFSQTSNAAIALKAYSLPLPHGQVGVFIENQQPIVELSQSRDRWVSDLAHELRTPLTSIRLVTENLQGRLQPPFSRWVEQMLPEINRLISLVQDFLELTHLEQNPSKYLHLTPVDLGELIDSVWQKLEPLTTQKQLSLLKIQPKEIVFYADSARLTQVFLNLFDNSIKYSPIAGTIRCEINLIPNGDTAEIIQVNIIDSGNGFAEADLPYVFDRLYRGEPSRHRQQLDTGSSNSAPVSTGSGLGLAIVKQIILAHDGSIRAKNDPQTGGAWLQIELPLT
>NC_019753.1|WP_015204885.1|4500992_4501745_+|response-regulator-transcription-factor
MLTLDMPKSPSSTKLGQTSRILLVEDEDLIREMLVVSLQEEGYEVVTAIDGRTALTFLQNPETTNIEFPFDLIILDLMLPQVNGLDLCRLLRHQGNPVPILIVSAKASETDRVLGLEVGADDYITKPFSMRELIARCRALLRRHRFSFSTPTPVLQYKDIVVYPQECRVLIRSEEVNLSPKEFRLLELFMSYPRRVWSREQLIDQVWGGDFVGDTKTVDVHIRWLREKLERDPSQPEYLITVRGFGYRFG
>NC_019753.1|WP_015204884.1|4499963_4500710_-|creatininase-family-protein
MLLHLSTWSEVEVYLKQSQGIILPIGSTEQHGPTGLIGTDAICAEAIARGVGDAVNAMVAPTINVGMALHHTGFPGTISLRPSTMILVIKDYISCLVKAGFTKFLFINGHGGNIATLKAAFAETYAHLADLNIPNADLVQCQIGNWFMCSSVYKLAKELYGHEEGSHATPSEVALTQYIYPEAIKQAALSAEVGSGHKIYGAADFRKRYPDGRMGSNPALATPEHGKQFYDLAVKELSNGYLEFLNTD
>NC_019753.1|WP_015204883.1|4498996_4499929_-|branched-chain-amino-acid-ABC-transporter-permease
MDFFNTYGFLIVSMLLGALLGLSLYLPLMAGQLSLASPGFYALGGYIAAILATKVFPSTDALFPIPLLLLEMLIAGVVSGLLGVIVGIPALRLRGIYLAIATIAFVEILRVFSLNLDITGGAVGIFGIPQPFQTPIEYLWIAVPLLFMSMLILYRLERIRVGRAFIAIREDELAAGAMGINPTYYKVLAFTLGAILAGVVGAVSAHFLNTWNARQGTFDASIIYLTSVLIGGSRTFLGPVLGGMVFTALPEVLRAIADTGGLPNWLAGFLRDGRLIIFGLLIVIGTIFFPQGLITPDLFKKRHKSKNPSI
>NC_019753.1|WP_015204894.1|4511397_4512432_+|pentapeptide-repeat-containing-protein
MNIEELLRRYAAGERDFREINLVGANLSGANLSGADLSGASFGSANLSRASLRGAKLKGAFLYGTDLSFAKLNDANLVDADLTKASLKGAVLIKANLKGSKLSGATLTAVNLRGANLEGVNLCGANLSGINLHSANLVEAKLSWANLTGARMSGAKLAAASLTGIKLRGAWLNGVDLRGVDLDGVDLSEAKLSGTNLTNANLPAANLSDAQMRVAILTQINLRAANLNGTWLNKANLSDANLSKADLSDAHLSDANLSGANLNGANLYEADLSRANLNSAYLWAAQLDVANLNGANLNGASMRGANLDDAELENALYNQQTVFPEGFDPHQAGAYFTGSPLVAA
>NC_019753.1|WP_015204895.1|4512822_4514268_+|hypothetical-protein
MSYKSEVKLDQRDQEIAALEKELNLADQLIKKLKRQNTVLKHRINFLENNSRPHPALVASRGNSPRPNKREYPPGKGGALVRQQRSKTRAIKLWRLRVATIAIALLGFTLVNWAVSSLTKLKPNENPKSVAAKLASASLSGQQSTIPAWAKASSQDIPTRQSGKEDLEIVYNLTTPPQFQPSEKLQVIVDELVAIADSKKLPTKDLSITLIDAKTGEIAGYQQKELRYPASVVKMFWMVALYGQLENGIWKNPQDFNLYTSKMIEHSNNDASSFILDHITNTKSQDKLPDNQFTVWLNQRDSVNRFFSSAGYEGININQKTYPIYYLRMEEPAGTESQMRGDPERPLRNVITTDHSARLLYEICLTKQAISAVASEKMCGLLKRDLKPEAWKTNSETSEDFNPIVGFSGQSLRDSEVNFYSKAGLTSSTRQEAAFVATKDNSTAYVIAIAGGDRAYSSDYKLFPKMSSVVFEKMVERSARK
>NC_019753.1|WP_015204896.1|4514333_4514723_-|50S-ribosomal-protein-L7/L12
MSAATEEILERLKSLTLLEASELVKQIEEAFGVSAAAPVGGMVMMPPGGGTPTEEVEEKTEFDVILEEVPADKKISVLKVVRTLTGLGLKEAKDLVESTPKAVKEAIAKDAAEDAKKQLEESGAKVSIK
>NC_019753.1|WP_015204897.1|4514781_4515351_-|50S-ribosomal-protein-L10
MGRTKENKSAIIAELKETLSDSQLAVVIDYQGLSVAEITDLRQRLIPKGAVCKVTKNTFMRIAVEGDQNWEPMTEFLQGSSAFLLVKEDIGGAIKAYQEFQKVSKKTELRGGVMEGRALDQNQVKAIGDLPSKEQLMAQIAGAINGVATKLALGINEVPASLARGLQAYADKDNSNSDAEAAPLLETES
>NC_019753.1|WP_015204898.1|4515615_4516332_-|50S-ribosomal-protein-L1
MAKKVSRRFQALLERVEDRAYDPTEALNLLKETATAKFPESAEAHIRLGIDPKYTDQQLRTTVALPKGTGQEVRVAVIARGEKVNEASTNGADIAGSEELIEDIQKGMMDFDLLIATPDMMPQVAKLGRVLGPRGLMPSPKGGTVTFDLAGAIAEFKAGKLEFRADRTGIVHVMFGKASFSAQDLLTNLKALQETIDRNRPSGAKGRYWRSIYVAATMGPSIEVDVNALRDLKLNEAA
>NC_019753.1|WP_015204899.1|4516448_4516874_-|50S-ribosomal-protein-L11
MAKKVVAVVKLALNAGKANPAPPVGPALGQHGVNIMAFCKEYNARTADQAGMVIPVEISVYEDRSFTFVLKTPPASVLIRKAAGIERGSNEPNKKKVGSLSRAQLQEIAQTKMPDLNANDIDAAVKIIEGTARNMGVTIND
>NC_019753.1|WP_015204900.1|4516880_4517531_-|transcription-termination/antitermination-protein-NusG
MTFAADESYDDAAHQAGATIQPRWYAVQVASGCEKRVKSNLEQRIQSFDVADWVLQVEIPQTPTVKIRKDGSRSPSEEKVFPGYVLVKMRLWRDEDGEEKINDDAWQVVKNTPNVINFVGSEQKRGYGRGRGHVKPVPLSVTEVERIFKQATEQEPVVKTHLAAGDKIIVLSGPFKDFEGEVIEVSPERSKLKALLSIFGRDTPVELEFNQVQKQS
>NC_019753.1|WP_015204901.1|4517527_4517752_-|preprotein-translocase-subunit-SecE
MAKKSEAEIEEKKAGFSPVEFFDSSKEELSKVVWPSRQQLISESLAVILMVSLSATIIYLVDNFFAWVAGKVFL
>NC_019753.1|WP_015204903.1|4518455_4518818_-|50S-ribosomal-protein-L19
MNAQEIIRSIEAEHLKTDLPTINVGDTVKVGVRVIEGGKQRVQPYEGVVIAQARSGINKSITVRRTFQGVGVERVFLLHSPRIDSIKVLRRGKVRRAKLYYLRDLVGKATRIKQRFDREI
>NC_019753.1|WP_015204904.1|4518983_4521443_+|glycoside-hydrolase-family-31-protein
MSDRISCGNARFTALSNGLVRLEWSPTGEFEDRCTVQVFTRPDPVPFKAIAFTDGVLRLDTDYIQITYKPDSERFNDANLQISWQCGKLSGSWTPSSVDYDNLGGTFSSLDLIHRNFKPVGVHPASVEASYPDTQEWIYKTLQQAHRIVRDRGEQTEFEDPPLWYWANFCPEEFPPHIQEFWKQWQHFPPGILSKSGYSVLNDSDSAAIEEGWLSDRTSFDKTDQPQINQNLTSQDWYFFAYGLDYAQALQDFVKLCGRIPMLPRWAYGVWFSLFGRLDESDYQQLVKQFDEKNLPLSVLILDVDWHGAGWCGWDWNNELFPNPPAFLEWGHNLGLRFGANVHTEGLSPRDSKFEMLCRVRGLDPADVKAGKVFATKNPTSDWIFHSWQPDGSGSFEATPEEMKEGWLLFNLADEEQANLFMQVLHIPREQDGIDFWWIDGTNAIHKGVNSQLWTNHVYYNHSQSQNNRRAMILSRTGGIGSHRYPLQFSADTYSHWEVLEFLVNFTAQAGNVGVAYWSHDLGGFYNHLLGAPTIDPELFVRWIQFGCWSPIVRLHSDHGVREPWAYGRRVLQAIRAAFHTRMEFIPYFYHLSRVAYDTGLPICRPLYLGYGDDVEAYQTPTEYLLGDRILVAPIVEAGCYRRVYLPSGIWWERATNKSYPGNQHLDLYVPLDQVPIFIQAGAILPLQPVTLRVETSPPSCLILEVYAGGEGELDLYEDDGESTAYQSNAGSRRLFTQTCDGENYIFTCEPLRGSYLGMSQERNFKIRWIGIVPNSQIEVIGVKLSNARWVGEVLEVTLEEVPQTSSWRLVVGAGLENN

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Crispr_ID: NC_019753_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_18

4687015-4687133

TypeV

Consensus_repeat	Method
CCAATACCCAGCCCAGTCCCAGA	CRISPRCasFinder

2 spacers

Cas14c_CAS-V-F

The CRISPR arrays of NC_019753_18

>merge|NC_019753|18|4687015-4687133|CRISPRCasFinder
CCTAGTCCTAGTCCAGTTCCTGAACCATATCCCAATCCTCTTCCAGAGCCAATACCCAGCCCAGTCCCAGAGCCAATACCTAGCCCAGTACCCGAACCAATACCTAGCCCAGTCCCAGA

>NC_019753|18|16|4687015-4687133|CRISPRCasFinder
CCTAGTCCTAGTCCAGTTCCTGA	ACCATATCCCAATCCTCTTCCAGAG
CCAATACCCAGCCCAGTCCCAGA	GCCAATACCTAGCCCAGTACCCGAA
CCAATACCTAGCCCAGTCCCAGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_157462360.1\|4682748_4683486_+\|DUF2993-domain-containing-protein	unknown	unknown	gnl\|CDD\|378597
NC_019753.1\|WP_015205047.1\|4690746_4691097_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015205035.1\|4679501_4681007_+\|4-alpha-glucanotransferase	unknown	unknown	gnl\|CDD\|237738
NC_019753.1\|WP_015205040.1\|4684510_4685113_-\|precorrin-6Y-C5,15-methyltransferase-subunit-CbiT	unknown	unknown	gnl\|CDD\|180961
NC_019753.1\|WP_015205049.1\|4692817_4693171_+\|DUF1257-domain-containing-protein	unknown	unknown	gnl\|CDD\|377725
NC_019753.1\|WP_157462470.1\|4690044_4690506_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015205037.1\|4681891_4682677_-\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|224108
NC_019753.1\|WP_015205032.1\|4677041_4677197_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015205033.1\|4677590_4678727_-\|endoribonuclease-L-PSP	unknown	unknown	gnl\|CDD\|129116
NC_019753.1\|WP_015205043.1\|4687238_4688330_+\|redox-regulated-ATPase-YchF	unknown	unknown	gnl\|CDD\|236583
NC_019753.1\|WP_015205039.1\|4683525_4684404_-\|phosphatidate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|178539
NC_019753.1\|WP_015205044.1\|4688402_4689059_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015205052.1\|4695391_4695661_-\|30S-ribosomal-protein-S15	unknown	unknown	gnl\|CDD\|180170
NC_019753.1\|WP_015205041.1\|4685165_4686701_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224893
NC_019753.1\|WP_015205051.1\|4694899_4695382_-\|PAM68-family-protein	unknown	unknown	gnl\|CDD\|371813
NC_019753.1\|WP_015205050.1\|4693364_4694588_+\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	Cas14c_CAS-V-F	-	gnl\|CDD\|223747
NC_019753.1\|WP_015205036.1\|4681070_4681895_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224343
NC_019753.1\|WP_015205048.1\|4691175_4692687_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|177094
NC_019753.1\|WP_015205045.1\|4689299_4689827_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319909
NC_019753.1\|WP_015205034.1\|4678872_4679304_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_157462360.1\|4682748_4683486_+\|DUF2993-domain-containing-protein	gnl\|CDD\|378597	pfam11209, DUF2993, Protein of unknown function (DUF2993). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	1.28857e-19
NC_019753.1\|WP_015205049.1\|4692817_4693171_+\|DUF1257-domain-containing-protein	gnl\|CDD\|377725	pfam06868, DUF1257, Protein of unknown function (DUF1257). This family contains hypothetical proteins of unknown function that are approximately 120 residues long. Family members include eukaryotic and bacterial proteins.	7.48591e-30
NC_019753.1\|WP_015205035.1\|4679501_4681007_+\|4-alpha-glucanotransferase	gnl\|CDD\|237738	PRK14508, PRK14508, 4-alpha-glucanotransferase; Provisional.	0
NC_019753.1\|WP_015205040.1\|4684510_4685113_-\|precorrin-6Y-C5,15-methyltransferase-subunit-CbiT	gnl\|CDD\|180961	PRK07402, PRK07402, precorrin-6Y C5,15-methyltransferase subunit CbiT.	3.32101e-135
NC_019753.1\|WP_015205037.1\|4681891_4682677_-\|rRNA-pseudouridine-synthase	gnl\|CDD\|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	4.04128e-94
NC_019753.1\|WP_015205033.1\|4677590_4678727_-\|endoribonuclease-L-PSP	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	1.59523e-58
NC_019753.1\|WP_015205043.1\|4687238_4688330_+\|redox-regulated-ATPase-YchF	gnl\|CDD\|236583	PRK09601, PRK09601, redox-regulated ATPase YchF.	0
NC_019753.1\|WP_015205039.1\|4683525_4684404_-\|phosphatidate-cytidylyltransferase	gnl\|CDD\|178539	PLN02953, PLN02953, phosphatidate cytidylyltransferase.	7.7837e-61
NC_019753.1\|WP_015205052.1\|4695391_4695661_-\|30S-ribosomal-protein-S15	gnl\|CDD\|180170	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed.	6.15434e-48
NC_019753.1\|WP_015205041.1\|4685165_4686701_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224893	COG1982, LdcC, Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism].	2.67255e-165
NC_019753.1\|WP_015205051.1\|4694899_4695382_-\|PAM68-family-protein	gnl\|CDD\|371813	pfam11947, DUF3464, Protein of unknown function (DUF3464). This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 137 to 196 amino acids in length.	1.3906e-72
NC_019753.1\|WP_015205050.1\|4693364_4694588_+\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.48658e-55
NC_019753.1\|WP_015205036.1\|4681070_4681895_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224343	COG1426, COG1426, Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown].	1.11655e-30
NC_019753.1\|WP_015205048.1\|4691175_4692687_+\|AAA-family-ATPase	gnl\|CDD\|177094	CHL00195, ycf46, Ycf46; Provisional.	3.80994e-161
NC_019753.1\|WP_015205045.1\|4689299_4689827_+\|hypothetical-protein	gnl\|CDD\|319909	cd07245, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.72044e-07
NC_019753.1\|WP_015205034.1\|4678872_4679304_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	1.28707e-41

>NC_019753.1|WP_015205041.1|4685165_4686701_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MNQESQAKTPILDTLRECANKPHAAFYTPGHKRGQGIYPQLADLLGESVFRADLPELPELDNLFAPEGVIKEAQQLAAEAFGAEHTWFLVNGSTAGVMAAILATCGSGDKIILPRNVHQSAIAGLIISGAIPIFVNPEYDPILDIAHSITPDAVAAALKQHPDAKAVMMVYPTYYGVCGDVKAIAHITHQYNIPLLVDEAHGAHFAFHPELPPSALSAGADLTVQSIHKVLGAFTQAAMLHVQGSKVDINRVSKALQLLQSTSPSYLLLASLDAARQQMALHGHQLMAKTLLLAKLARNQIRQIPGLSVLETEHIQLNEAGFFALDPTRLTVTVSGLGISGFEADEILHTQLGVTAELPSLQHLTFIISLGNTSEDIEHLIQAFTTLSKDYQQESLLVETPSSGVVPDWYSVGLFTEETIGVARISPREAFFVPAETLPIENIWDTCGGLHPYISAELICPYPPGIPVLMPGEQITPSAIEYLQQIIKLGGSITGCSDRTLKTIKVVLSQS
>NC_019753.1|WP_015205040.1|4684510_4685113_-|precorrin-6Y-C5,15-methyltransferase-subunit-CbiT
MHTQLWPYVTPGIPDDLFERLPGIPLSKREVRLLIISALRLKSDSVLWDIGAGTGTIPVETGLLCPKGRVIAVERDEDVASLIRRNCDRFGVGNVEVIEGSAPECLKDIPHQPQRVCIEGGRAIKTILQEVWQYLPSGGRVVATAANLETLYSVSGTLSELQARNIELVQSSVNRLETRGNRQTFSAVDPIFILSGEKLD
>NC_019753.1|WP_015205039.1|4683525_4684404_-|phosphatidate-cytidylyltransferase
MPVSRILSGIVAIALALGLLFLGGWYFTLGFCVIIYLGQQEYFQLVRAKGIAPAGKTTLVVSQMLLITSTIAPELVDPMFALAGTLICFYLLFQPKIATIADISTSILGLFYGGYLPSYWIRLRVGLSPAIASNLPLNGYWPESWTNIHGFPQGLTVTLLAFMCIWAADIGAYTFGKFFGRTRLSDISPKKTVEGALFGIAGSIATATIGAWYLHWSIWQLSGITFGLLIGITSLLGDLTESMMKRDAGVKDSGQLIPGHGGILDRADSYVFTAPLVYYFFTLLLPLLAKLS
>NC_019753.1|WP_157462360.1|4682748_4683486_+|DUF2993-domain-containing-protein
MLQEYGKALTIKQSRIISTVLSPACGVWLRSQVEQVKELQVKISGGDRQILGGYIPHISIIADHAVYQGLHLSKINLSAENIRINLSQVIKGKPLRLLEPIPVTGQMLLEETDLKASLASPLLSNALTELLGTLLTSAGINQPNELLKDNPIKWQQVTLDNNQLTIAGVLANKSDNLTPVAIRTGLELASSHVLRLAPLHIDTPLESASRNLDSFELDLGSEVDIEELKIMPGQLVCRGSINVIP
>NC_019753.1|WP_015205037.1|4681891_4682677_-|rRNA-pseudouridine-synthase
MAERLQKIISQWGIASRRQAEKMILAGRVRLNGVVVELGQTANPELDRIEVDGKPIKPLNRPQHLYILLHKPAGVVSTCHDQRNRKTVLDLLPPELRQGQGVHPVGRLDAESTGALLLTNDGELTFILTHPRHCIPKTYHVWVEGHPPKSVLEVWRRGVVLDGRKTLPAQVRILKQQNDQTLLEIILREGRNRQIRRVAEQLGYPVVHLHRTAIGSICLNRPGLLLAGDYRLLEEFEIDFLQNQVNITSIEVPTNIKEGSV
>NC_019753.1|WP_015205036.1|4681070_4681895_-|helix-turn-helix-domain-containing-protein
MKETQIHIHQEQIDKLKDIGSRLRQFRQAQSLSLEDVASKTRVQARLLKAIEEGRIDILPEPVYVQGFIKRFADAIGLDGEDLASEYPTWPSIFFIKPSWLSLPSAQLRPVHLYFSYILLVFLAVNALSAIVNKSAIQVSNADISEPKLDQPVAKSRDLQASLPDKLHLNHSSSKPAEITQAMVVSENTTTTEPVRVGVTLKAESWMQVIVDGKKEFEGTLQPGDQRTWVAKEQLTVLAGNAGGVLIAFNDEKPKELGEPNKPQKVTFEANEKF
>NC_019753.1|WP_015205035.1|4679501_4681007_+|4-alpha-glucanotransferase
MPFPRSSGILLHPTCFPSRFGVGDLGIEAYQFIDFLRDTAQQYWQVLPLGPTGYGNSPYMSYSAIAGNHLLISPEKLQDQGLLTDEDLANIPEFPVDRVDFGAVIETKIPLLQKACENFKHKATPVQQKEFEGFCQSTAHWLDDYALFMALGDAHQGAGWHTWEPEIAKRKPEALEQWGLHLSDEIFSQKFLQFEFFRQWTELKSYAKLAGVQIIGDIPIYVAHNSAEVWSHPEIFCIDEETGQASLMAGVPPDYFSATGQLWGNPVYNWEQLQQDNFKWWVQRFKSLLDYVDLIRIDHFRGFESYWAVKQGETTALNGEWIKAPGEAFFKALNEQLGVLPILAEDLGVITPEVEELRDKFEFPGMKILHFAFGSDEDNIYLPFHYPRNCLVYTGTHDNDTTVGWFNQLSDQERESVLSYLGCTSADGIHWDLIRLALSSVANQALIPLQDVLGLDSNARMNLPSTGDGNWEWRYRADALTDEVRSRLKNMTVNFGRAPKK
>NC_019753.1|WP_015205034.1|4678872_4679304_-|NUDIX-hydrolase
MAYRNPTPTVDIIIELIDRPHRPIVLIERQNEPFGWAIPGGFVDYGESVETAAQREAQEETGLQVELIEQFYVYSDPNRDPRQHTMSVVFIATATGEPQSGDDAKSLEVFDSWRIPSNLCFDHDRIMRDYWRYRHYGMRPRLI
>NC_019753.1|WP_015205033.1|4677590_4678727_-|endoribonuclease-L-PSP
MDADELLEQYAEGERNFEESDLSHENLKGADLSEINFCYADLSNADLSRASLKDAKLIRVNLSNADLSWADLRGADLSGANLENANLSKASLDQANLTNTDLSSANLNRASLDYALLSKANLINADLSGTNLVGADLGRANLENADLSNATLDNSILISANFGAANLKKASLCNANIERASLEGANLISANLNGTNLSNVDLSDANISLATYKNADLTGARMPDGEIYQPEGYDKGFGNTEKPLEKETPMTRKVINTEQAPKPVGPYNQAIVASGQMIFVAGQIAIDPRLGDIVYTDDVAKQTERVMENLQAILTAAGATFKDVVKTSVFLKNMNDFAAMNAVYAKYFDEETAPARACVEVARLPKDVLVEIDCIAVI
>NC_019753.1|WP_015205032.1|4677041_4677197_-|hypothetical-protein
MNKKILFGASTAFIALTSLAVATVQQMPRAVAHRANEQVIAHHTPSPLVTS
>NC_019753.1|WP_015205043.1|4687238_4688330_+|redox-regulated-ATPase-YchF
MLTAGIVGLPNVGKSTLFNALVANAKATAANFPFCTIEPNVGVVAVPDERLNVLAKISESAQIVPTRVEFVDIAGLVKGASQGEGLGNQFLSHIREVDAIVQVVRCFENDDIIHVAGSVDPLRDIEIINLELGLADLSQIERRIERTRKNARTNKEAQIELSALEKLSTALNEGKPARQVTLSEEEAESVKLLGLLTSKPIIYATNVSEDDLATGNQWVEQVRQFATQENAQVVIISAQVESELVDLPEAEKLEFLESLGVKEGGLKSLIHATYELLGLRTYFTTGPKETRAWTIKTGMSAPQAAGVIHTDFERGFIRAETVAYNDLVATNSLSAAKEKGLVRSEGKEYIVNEGDVMLFRFNV
>NC_019753.1|WP_015205044.1|4688402_4689059_-|hypothetical-protein
MQIPHFPESNHPIVKSLFHHSDQELLTLFQRYPEQGKFFTAIFCRYSPIVYTLIRHSARSPVQADYLFALTWRHIYYELGGLNLREDTGTEVSSFQNWLINMTAVCINEAELPPVESIHYSLQAASPPLWCYMEQALEQLPPITRLMVLMAQTFHWSETRISAYLQAEGEMLSAADVKAQLLQGYHLLEVALPEDLRVIYLNNFKVESSQPLIDNITN
>NC_019753.1|WP_015205045.1|4689299_4689827_+|hypothetical-protein
MPLDSLFSTQGIMVMLLAAYAVAMWMFLTSAPKVYTIMVSDLEIARQLYEGLLNLPVADVPLHYYYNYEQTLGVPSIDPLYLSAPIATSPVRGGNGSEGLWYQLKKNTQLHIISGASLGQKNRHRHVSFDHDCLEQVLMRVQLRGIKHKIRSDKPLNFLVKDLEGNVIEMSEVSN
>NC_019753.1|WP_157462470.1|4690044_4690506_-|hypothetical-protein
MLLQGCQSSRNSSATWKIYRNPRYQFEFPYPSNWIATPMPDNRDGQAFRDPQQPEIEIRGWAEHRLSNMILNNRTSTVKKTAQPLQLNFTTQQGVTGQLQVKVGSDLNIMELSLNQGLMLYHWRAQAPSKQFADYYRFFYYIASNYRLPPVSK
>NC_019753.1|WP_015205047.1|4690746_4691097_+|hypothetical-protein
MQDKQKVTLYLPPGLHRQMKIRAAVDAESMSSIVERAIVFYLDHPEIVDEVESSYGQTHQIYDCPRCANPVVLRDGEMVALGNQPGVVAEELANLEVREEVNSRNDSQGEQELVPC
>NC_019753.1|WP_015205048.1|4691175_4692687_+|AAA-family-ATPase
MQEELNILIQAQYPLIYLVTSEEERAEKTIAAIAQMKPQPRRVFIWTVTHGIIEYGQPRHLTQHNTVSPEAAVEWVIRQKEPGIFIFKDLHPFIDSPATTRWLRDAIAGFKGTNKVIILMSPVQHIPIELEKEVVVMDYPLPDLAELNHVLSYQLEQSRTRKTSTETREKLLKAALGLTKDEAEKVYRKAYVKTGRLTEEEVDIVLSEKKQLIRRNGILEYIEEDETIDAVGGLDELKRWLRQRSNAFTERAREYGLPQPKGMLILGVPGCGKSLIAKTTARLWSLPLLRLDMGRVYDGSMVGRSEANLRNALKTAESISPAILFIDELDKAFAGSGGSADSDGGTSSRIFGSFLTWMQEKTSPVFVMATANRVERLPGEFLRKGRFDEIFFVDLPTPEEREEIFKIHLIKRHRDIERFDIEQLAKVADGFSGAEIEQALIAAMYDAFAQDREFSQLDIIAAIKATMPLSRTMTEQVTALRDWARQRARPAASSVAEYQRLEF
>NC_019753.1|WP_015205049.1|4692817_4693171_+|DUF1257-domain-containing-protein
MSHFSTLRTKITDAEILKASLRDLGISVKSEADVRGYNGQRVRADLVAVLEGEYDLGWSRNGDGSFDLIADLWGVAKKHNQTELINSINQKYAVNKTLAEVKNRTGLKDANVKLVLQ
>NC_019753.1|WP_015205050.1|4693364_4694588_+|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MLVYESKLEGAKHQYEKLDEAIRTGVFVRNACIRLWVDGGAKSRNDLYKYCKILADNPEFPWAKLLNSQARQASAERAWASISRFFDNCRKKIPGKKGFPKFKKDRPNHGSIEYKQTGFKLSEDTKYISFTDGFKAGCFRLWGTRDLHFYGLDKINRVRVVRRADGYYAQFLIDHDRIEPREPSGTTVGLDVGLSHFYTDSNGKTVDNPRHLRKSEKRLKRLQRRASKKFKKGQSQSNNYKKAKKKLARSHLQVSRQRKDFVVKTALCVVQSNDLVAYEDLQVRNMVKNHCLAKSINDASWAMFREWVEYFGKVFGVATVAVPPYNTSQKCSNCSAIVKKSLSTRTHVCACGAVLDRDHNAALNILELGLRTVGHTGTQKASGDSNLCIDEGTCQDKLDRGKRKPQE
>NC_019753.1|WP_015205051.1|4694899_4695382_-|PAM68-family-protein
MSSEERQSEDAERVRLPFEPAKKTRQKPPKTQPAPQAITKNPTEKPKPASNSAAVPTVVSNRMIRRVAFFSGLPTAMGMLTFIISYLIVSKEWFNLPNVAVVIISISFFGLGVLGLSYGVLSASWDEERAGNLLGWNEFTTNLGRMTAAWRSKSTVKTED
>NC_019753.1|WP_015205052.1|4695391_4695661_-|30S-ribosomal-protein-S15
MSLTQQRKQEIMTEYQVHETDTGSAEVQVAMMTERINRLSTHLKANHKDHASRRGLLTIIGQRKRLLAYIQKKDQQNYQALIARLGIRG

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Crispr_ID: NC_019753_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_19

4712168-4712424

TypeV

I-D,II-B

Consensus_repeat	Method
AGCGAAAATTACTAATAATCCCTTTTAGGGATTGAAAC	PILER-CR
TAATAATCCCTTTTAGGGATTGAAAC	CRT

3 spacers

The CRISPR arrays of NC_019753_19

>merge|NC_019753|19|4712168-4712424|PILER-CR,CRT
AGCGAAAATTATTAATAATCCCTTTTAGGGATTGAAACAGGAATATATACCCATCTGTGTATATGTACTTTGCTCCAGCGAAAATTATTAATAATCCCTTTTAGGGATTGAAACGATTATGCTCCATCGGTTCGGGTCGGGGCTGTTCGGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAACATCGGGGCTTTTGGCTGTGGTAAATCTTTATTTAGCGAAAATTACTAATAATCCCTTTTAGGGATTGAAAC

>NC_019753|19|7|4712168-4712424|PILER-CR
AGCGAAAATTATTAATAATCCCTTTTAGGGATTGAAAC	AGGAATATATACCCATCTGTGTATATGTACTTTGCTCC
AGCGAAAATTATTAATAATCCCTTTTAGGGATTGAAAC	GATTATGCTCCATCGGTTCGGGTCGGGGCTGTTC
GGCGAAAATAGCTAATAATCCCTTTTAGGGATTGAAAC	ATCGGGGCTTTTGGCTGTGGTAAATCTTTATTT
AGCGAAAATTACTAATAATCCCTTTTAGGGATTGAAAC

>NC_019753|19|5|4712180-4712424|CRT
TAATAATCCCTTTTAGGGATTGAAAC	AGGAATATATACCCATCTGTGTATATGTACTTTGCTCCAGCGAAAATTAT
TAATAATCCCTTTTAGGGATTGAAAC	GATTATGCTCCATCGGTTCGGGTCGGGGCTGTTCGGCGAAAATAGC
TAATAATCCCTTTTAGGGATTGAAAC	ATCGGGGCTTTTGGCTGTGGTAAATCTTTATTTAGCGAAAATTAC
TAATAATCCCTTTTAGGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_015205058.1\|4708404_4708740_-\|ribulose-bisphosphate-carboxylase-small-subunit	unknown	unknown	gnl\|CDD\|365873
NC_019753.1\|WP_015205069.1\|4718310_4719249_-\|putative-2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|180488
NC_019753.1\|WP_015205062.1\|4712469_4712670_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|224638
NC_019753.1\|WP_015205059.1\|4708786_4709197_-\|chaperonin-family-protein-RbcX	unknown	unknown	gnl\|CDD\|367041
NC_019753.1\|WP_015205064.1\|4712966_4714730_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_019753.1\|WP_015205065.1\|4714972_4715494_-\|DUF937-domain-containing-protein	unknown	unknown	gnl\|CDD\|227690
NC_019753.1\|WP_015205073.1\|4721434_4722892_-\|DUF3459-domain-containing-protein	unknown	unknown	gnl\|CDD\|200477
NC_019753.1\|WP_015205055.1\|4698718_4701115_-\|NACHT-domain-containing-NTPase	unknown	unknown	gnl\|CDD\|227922
NC_019753.1\|WP_015205072.1\|4720901_4721318_+\|fasciclin-domain-containing-protein	unknown	unknown	gnl\|CDD\|225214
NC_019753.1\|WP_015205066.1\|4715664_4717224_+\|DUF697-domain-containing-protein	unknown	unknown	gnl\|CDD\|368297
NC_019753.1\|WP_015205060.1\|4709289_4710720_-\|form-I-ribulose-bisphosphate-carboxylase-large-subunit	unknown	unknown	gnl\|CDD\|176981
NC_019753.1\|WP_071881132.1\|4707397_4707646_+\|response-regulator	unknown	unknown	gnl\|CDD\|226229
NC_019753.1\|WP_015205071.1\|4719612_4720614_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_019753.1\|WP_015205061.1\|4711217_4711991_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723
NC_019753.1\|WP_015205057.1\|4707930_4708248_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015205063.1\|4712659_4712878_+\|HicB-family-protein	unknown	unknown	gnl\|CDD\|374224
NC_019753.1\|WP_041226138.1\|4705614_4705896_+\|response-regulator	unknown	unknown	gnl\|CDD\|381093
NC_019753.1\|WP_083890046.1\|4705920_4707219_-\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|376573
NC_019753.1\|WP_015205067.1\|4717414_4717990_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NC_019753.1\|WP_015205056.1\|4701274_4705618_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|274362

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_015205058.1\|4708404_4708740_-\|ribulose-bisphosphate-carboxylase-small-subunit	gnl\|CDD\|365873	pfam00101, RuBisCO_small, Ribulose bisphosphate carboxylase, small chain.	1.90704e-58
NC_019753.1\|WP_015205069.1\|4718310_4719249_-\|putative-2-dehydropantoate-2-reductase	gnl\|CDD\|180488	PRK06249, PRK06249, putative 2-dehydropantoate 2-reductase.	9.81252e-179
NC_019753.1\|WP_015205062.1\|4712469_4712670_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|224638	COG1724, COG1724, Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only].	1.80451e-22
NC_019753.1\|WP_015205059.1\|4708786_4709197_-\|chaperonin-family-protein-RbcX	gnl\|CDD\|367041	pfam02341, RcbX, RbcX protein. The RBCX protein has been identified as having a possible chaperone-like function. The rbcX gene is juxtaposed to and cotranscribed with rbcL and rbcS encoding RuBisCO in Anabaena sp. CA. RbcX has been shown to possess a chaperone-like function assisting correct folding of RuBisCO in E. coli expression studies and is needed for RuBisCO to reach its maximal activity.	2.94477e-64
NC_019753.1\|WP_015205064.1\|4712966_4714730_-\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.0368e-43
NC_019753.1\|WP_015205065.1\|4714972_4715494_-\|DUF937-domain-containing-protein	gnl\|CDD\|227690	COG5403, COG5403, Uncharacterized conserved protein [Function unknown].	0.000167875
NC_019753.1\|WP_015205073.1\|4721434_4722892_-\|DUF3459-domain-containing-protein	gnl\|CDD\|200477	cd11338, AmyAc_CMD, Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins. Cyclomaltodextrinase (CDase; EC3.2.1.54), neopullulanase (NPase; EC 3.2.1.135), and maltogenic amylase (MA; EC 3.2.1.133) catalyze the hydrolysis of alpha-(1,4) glycosidic linkages on a number of substrates including cyclomaltodextrins (CDs), pullulan, and starch. These enzymes hydrolyze CDs and starch to maltose and pullulan to panose by cleavage of alpha-1,4 glycosidic bonds whereas alpha-amylases essentially lack activity on CDs and pullulan. They also catalyze transglycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules. Since these proteins are nearly indistinguishable from each other, they are referred to as cyclomaltodextrinases (CMDs). The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_019753.1\|WP_015205072.1\|4720901_4721318_+\|fasciclin-domain-containing-protein	gnl\|CDD\|225214	COG2335, COG2335, Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane].	5.27031e-45
NC_019753.1\|WP_015205056.1\|4701274_4705618_+\|PAS-domain-S-box-protein	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	1.67708e-105
NC_019753.1\|WP_015205055.1\|4698718_4701115_-\|NACHT-domain-containing-NTPase	gnl\|CDD\|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	2.32219e-137
NC_019753.1\|WP_015205066.1\|4715664_4717224_+\|DUF697-domain-containing-protein	gnl\|CDD\|368297	pfam05128, DUF697, Domain of unknown function (DUF697). Family of bacterial hypothetical proteins that is sometimes associated with GTPase domains.	9.56985e-63
NC_019753.1\|WP_015205060.1\|4709289_4710720_-\|form-I-ribulose-bisphosphate-carboxylase-large-subunit	gnl\|CDD\|176981	CHL00040, rbcL, ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit.	0
NC_019753.1\|WP_071881132.1\|4707397_4707646_+\|response-regulator	gnl\|CDD\|226229	COG3706, PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms].	3.37183e-13
NC_019753.1\|WP_015205071.1\|4719612_4720614_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.02293e-98
NC_019753.1\|WP_015205061.1\|4711217_4711991_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	6.03097e-159
NC_019753.1\|WP_041226138.1\|4705614_4705896_+\|response-regulator	gnl\|CDD\|381093	cd17538, REC_D1_PleD-like, first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains. PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.95069e-25
NC_019753.1\|WP_083890046.1\|4705920_4707219_-\|IS4-family-transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	9.6362e-12
NC_019753.1\|WP_015205067.1\|4717414_4717990_+\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	4.4634e-37
NC_019753.1\|WP_015205063.1\|4712659_4712878_+\|HicB-family-protein	gnl\|CDD\|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	1.57133e-19

>NC_019753.1|WP_015205061.1|4711217_4711991_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MAVTTQQLIQWKQQARPIVVLTAWDYAIAQLLDASGVDVVLVGDSLGMVTLGYETTLPVTLEEMLHHAKAVRRGVQQALVVVDLPFLSYQESPQQAIHSAGRVLKETGAQAVKLEGGYPAMAETVGRLVKAGIPVLGHIGLTPQSVHQLGYRQQGKTADAGERILGEAIALEQAGAFGIVLEHIPASLAAQITQKLTIPTIGIGAGSDCDGQVLVTADVLGLSQRQPPFAKSYVNLREIITQAVTDFSGEVRERNFP
>NC_019753.1|WP_015205060.1|4709289_4710720_-|form-I-ribulose-bisphosphate-carboxylase-large-subunit
MAYSQTKTQSKTGYKAGVQDYRLTYYTPDYTPKDTDVLAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDLLTDLDRYKGRCYDIEPVPGEDNQFIAYIAYPLDLFEEGSVTNLLTSLVGNVFGFKALRALRLEDLRIPVAYLKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYEVLRGGLDFTKDDENINSQPFMRWRDRFLFVQEAIEKAQAETGEIKGHYLNVTAPTCEEMMERAEFAKEIGTPIIMHDYLTGGFTANTTLAKWCRRNGVLLHIHRAMHAVIDRQKNHGIHFRVLAKCLRMSGGDHLHSGTVVGKLEGEKGITMGFVDLMRENYVEQDRDRGIFFTQDWASMPGVMPVASGGIHVWHMPALVEIFGDDSCLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRNLMREGGDVIREACKWSPELAVACELWKEIKFEFEAMDTL
>NC_019753.1|WP_015205059.1|4708786_4709197_-|chaperonin-family-protein-RbcX
MDLKQVAKDTAKVLSSYLTYQAVRIILTQLTETNPPLAYWLSNFSGKEKIQDGEAFLKELLSEKQDLAFRVMTVRQHLAEEVTDYLPEIVRTGIQQANMEYRRQHLERLTQLTSSNPSTYPEQPIDSEPNLDNISD
>NC_019753.1|WP_015205058.1|4708404_4708740_-|ribulose-bisphosphate-carboxylase-small-subunit
MQTLPKERRYETLSYLPPLSDAQIAKQIQYMIDQGFIPGVEFSESSAPEQHYWTLWKLPLFNAGSVNEVLNEVKACRSEYSSNFIRVVGFDNVKQCQVLSFIVHKPTASRY
>NC_019753.1|WP_015205057.1|4707930_4708248_+|hypothetical-protein
MENQPSSSNQEESETCSQVKIITSDSIQSSYNPICCPQNSPLSELREAQIIEENKLNCNWTLQKIKVVPYPQPEFHINHDKSTEQAGGQRGRGGRGAEGQRGRGS
>NC_019753.1|WP_071881132.1|4707397_4707646_+|response-regulator
MPILMITVLDDSDSVDRAFEVGTTDYITKPIQWSVLRYRVRRLIQQYLQARRIDSLMEELQQANLEVKRLTQVVARYERGDL
>NC_019753.1|WP_083890046.1|4705920_4707219_-|IS4-family-transposase
MVEDEVIAKQLEKLLTPAITNQENYYRKLGLRERILNLPLMMAAVLTLLWRDVAGVRELTRMLARDGFLWCSPTKVSQQAVSQRFLTFPSELFEKVFKDLLPSLRATWHSRNQRPLPESIQFTLSKFEKIWIVDGSTLEALFRKLKSLEETQRGQLAGKMSTVIDLMTRLPVEIWFEENSKASDIKLEENILNLVTKNTLLLLDRGFYHFNFWFQLIEKKVDFITRIKKGAAIKVEQIFTDSYELRDRKIRFGSGTKKTPFITLRLIEVRSGKTWHSYLTSVLDPNILPPYVVADLYRRRWRIEDAFNTVKRLLGLSYLWTGSINGIKLQIWATWLFYAVLVDLGDAVADELALPFDEISLEMIYRGLYHFTMAHQKGKATDPVKYFADPENRDLGIIKQQRNPNVKLIVAPFPNLQRGSDQFFFNNSLKAS
>NC_019753.1|WP_041226138.1|4705614_4705896_+|response-regulator
MSKDSVLKDSPLVLIVDDDKSMRMLLRLALEQEGYQVVEAQDGQACISAYKQHQPDLILLDAVMPVMDGFTCCTQLRSLSGTNSSNLDGLDHW
>NC_019753.1|WP_015205056.1|4701274_4705618_+|PAS-domain-S-box-protein
MGNLSTSLISSVIGTLGKMEVALAIISEAIVQTNDQGYIHWSNQAFDSLIDREHFDVLGTKLIEILPVEQQGVQVLEALHPASLALQNTYIINQDAPTGQQKAQISNIYSYSEPPLTKGIYEFQKAGKKLVLEISWAKIQLEQQANIIFVIRDITAQYQQQQQLQQQLQIEIDKRQQLERAIRDSEERFKWLLEATFNSVDGLLAIDSQGQIVYCNDKFKEIWSIPDAVLTLVDLDEILLLFSQQIKDPEAFLERSKNLYSKPDTKFTDILEFKDGKIFECYSQPQQLGNKIIGRFSCFRDITARKQIEAEIQRSLSLLKATIESTDDAIIAFDMQGNITCINQKFVEMWLIPDEIMASPDINQRLLFIESQIQYPENFFNAFQEFSQQPDAECCYLLKLKDGRSFECQSRQHRLEKTVLGRVWCFRDVTKTKQMEARIERERSLLQATIDSTNEGILAVESNGQITCCNQQFKEMWSLSDELIKTTDLQRRMEFIAEKLKYPEVWLQTIIELSNKPEVSRIDTLELRDGRLFERHIQPYKLGSQIIGRVFSFRDITDTKLAEIQLQQAKGQLQAVLNAVPGGIAWIDSNLNLLGVNNYLAEIFGLMPENFVGKNFNFFKSTHAEIIDFLQQFFSSYVQKTSIEVDWKVDSSRVSYLVAGQKYLQGQAAVFAVMEITKRKESEELLQQQTASMKAAMDRALLLKQITQQIRQSLDTRKILQTASNLIGENFKINRCVIHLITDPNLACPCVAEYVQPGYLSLINEEIPINGNPFAEALIAEDRAMAVYNVYNEPLLTAAIPILEYAQLKSMLAMRTSYKGEVNGFFGLHHCEEFHNWTTDEIELLEAVAAQVGIALAHARLLEQETHQRQQLSQQNLDLEKAKIAAEAASLAKSEFLAMMSHEIRTPMNAVMGMSSLLLNTELKPQQQGFVKTILHSSEALLAIINDILDFSKLEFGKLELEKQQFNLQKCVEGAVTMLAPKAAAKGLQLLSKIDPQTPVSIIGDATRLRQILVNLLSNAIKFTHAGEVSISVTAKQSELSQHSSLNNPIYQIKFAVKDTGIGIPDNRREKLFKRFSQVDSSISRRYGGTGLGLAISKEITELMGGTIWVESEVDIGSTFYFTMLAEAGILIADNNALDSRLTIPRIAEKLPLKILLAEDNLVNQEVAMLTLETLGYQVDVVSNGLEALQAVQRQTYDVVLMDVQMPEMDGLTATHCIRQAWSNEEFLAQRNGSSIISSCPRIIAMTAYATKGDRERCLEAGMDDYITKPINISELIQALYRCQPKALSGQSTPTLVEQKSDRSEYLEAELIMAEEDNCTIPKLPPQVPNPIDAKVLESLRQMAGSNANEFLAKILDNYFEETPRLLSAMQEAVSTEDPAALAYAAHKLRSASATLGATNLSLLCKELETLGRAGSTLGGLPVIAQIETAYEAVKLALRQEIQENHA
>NC_019753.1|WP_015205055.1|4698718_4701115_-|NACHT-domain-containing-NTPase
MAKRSLKASPSGIEKAKNAFKRAGWTQEFLAEQVGITTRQSIWKFFSGKSVERNIFIEICFQMNLDWQEIADLPKDPEVKISQPNQNQKLDIESLVQKLRSHCYDKIADQCSTLRLLDVAQPLQLNDIYVNVNILEVLSNQQWLQVSDFNNFNPEKFNRLGLTQYQQRIAGLQAITNSTKVMVFGKPGAGKTTFLQKIALLCNQGEFEANQVPIFLRLRNLAADLDLVKSANLLDYLYQEISSSNIERSELETLLQHGRVLLLLDGLDEVPTKESDEVLQQIRQFCNQYYKNKFIISCRIAARQYQFEGFSDIEIADFDFSQIQAFAKKWFVAVCKNIELGLAKASQFLEKIELPQNLQIKELATTPLLLNLTCSVFQVKADFPARRSDLYKQGLDLLLTRWDESRGIKRDEIYHHLSLLQKIKLLSKIAAITFEQHDYFIEQSTLEEHIANYLKSIFINNLDEDELQLNSAAVLKSIEVQHGLLVERSKGIYSFSHLTFQEYLTARNIVANLEPKILSQNLNKLVNHITEPRWREVFLLTAGLLGNADQLLQLMKQKLDQMLAQDEQLQQFLTWLNQKCESLKVNYQPAAIRAFYMRLALAQNSHTPPNFNLAIALDLSLAGNLTPELKLDLALDRVLRLSLSLPEHPTIDRVLDLGFALPIQADIQSKTVRSPLQEALQNLKIQLTQLDGSENLASWWQANSSTWTEELRTAMIRHRNIGQNWNFTLQQQQTLQQYYQANQFLLECLNSNCQVSPNLPREIQQTLLLPISETSPDSHNLSSVTMLRASPGNKFIGR
>NC_019753.1|WP_015205062.1|4712469_4712670_+|type-II-toxin-antitoxin-system-HicA-family-toxin
MKVRELIRLLEDDGWYLARTRGSHRQFYHPEKTGVVTVPGKFSKDVPIGTLKAIFKQAQLGDEDEI
>NC_019753.1|WP_015205063.1|4712659_4712878_+|HicB-family-protein
MKYKYEIIIEKAENNYSAFSPDVPGCITVGDTVEETLQEMEEAIEFHLEGLKERGLPIPEPKTNHFYVEVNA
>NC_019753.1|WP_015205064.1|4712966_4714730_-|serine/threonine-protein-kinase
MSLCINPNCPRINADNDNTRFCLSCGSELLLDNRYQVMRLLTDNNNFSKVYEAYEQNTPKIIKVLKEHLNTHPRAVELFQEEANILGQLNHRGIPQIDGYFQYQTRDGLLLHCIAIEHIEGYNFEELLQQQGNRLISEKEAIAYLRQIAEILVAVHSQDYYHWNIKPSNIKFAPSDASRGGDTRAVYPTPQATGNLVLIDFATARELTYLHLASNGMEDAIPAVISPGYTPPEQVSNQPLLQSDFYALGRTFVFLLTGYHPLDFYDPQTDEIYWRGNADGISPLLMDFLDWLMAQNPSDRPINANEILQRLDELERELYYSDSPFPLTIIAGLIIAFWAKLLRFPLFGWLEYVTSTTLRIIIFITVIITVPGVLAVVSPKVICSLGLSSDACPSQEPEKIGDIDYFPPEEGTDSQGKTAEFEVAVLSREYEWRLGSASQIQSNDEIIKVQDLQQRLEQQGVLNRLGDTTDIMSVGTASCEGAVAAEELRALQRAKNIQLLTKTLFGNSPTVKNYHLLNLGKFKDCEKTINPSETSYQRSLIIVGVSKKDEGVLLDEALYDRLNKKPFGDFKLEDYSLGSQERFQLTN
>NC_019753.1|WP_015205065.1|4714972_4715494_-|DUF937-domain-containing-protein
MTFFSQILGALQNSDQAASSGQVASILSTVDQVSDSYGTDRNTTQSALSIVGNYVRSALQQKRDTEGSEQAQSIVNQYSGSYPNPQAVNSVFSPDQTNGVIDAVAQKTGLNPQMIQQMLPILVPIVLNMLQTGTNAQSPQGGNPVLNAFLDADHDGDVDISDAMHLAARHLSP
>NC_019753.1|WP_015205066.1|4715664_4717224_+|DUF697-domain-containing-protein
MPLPRLLTLIFGISLILGLVLWLINSLYRLYWQVSFTSPFLAFLLLLLIIALLGVLIWSFIYYLGLFGRRQTPRRRLAPKVPAVKTEAAEETLRAVRQQVGQIQDEVAKQALLERSREIEANLARGELLVVVFGTGSAGKTSLVNGLIGRMVGKVDAPMGTTEVGETYTLKLKGLNRQILITDTPGILEAGVAGTEREQLARQLATEADLLLFVVDNDLRQSEYNPLKALAEIGKRSLLILNKTDLYTQEDQEVILARLRERVRGFIASSDIVAIAANPEAALLESGETFKPDPDIMPLIRRMAAVLRAEGEDLVADNILLQSQRLGDDARRLLDAQRRRQAEKVVERFQWIGAGVIAVTPLPVVDLLATAAVNAQMVVEIGRIYGCELNMDRGKELALSLGKTLASLGIVKGAIELISTALQLNVATYLLGKAIQGVTAAYLTRIAGKSFIEYFRQDQDWGDGGITEVVQRQFQLNRKDEFVKAFVTEAIARVVKPLTDNSEAIEAEKIHRNQEDDWQ
>NC_019753.1|WP_015205067.1|4717414_4717990_+|Uma2-family-endonuclease
MQATETKTTTPEQYLEIETLAEYKSEYYDGEVVPMAGGSPNHNRIALNFSGALNFALKGQKYDVFMTDMRLWIPRQRIYTYPDVMVVAGNLEFAEGRKDTITNPLLIVEVLSKSTKNFDLGEKFEFYRTIPTFQEYILIDQTKIHVEQFAKTTDNKWLLSEYEDENATLALTNLQFEIPLVDIYSRVEFNE
>NC_019753.1|WP_015205069.1|4718310_4719249_-|putative-2-dehydropantoate-2-reductase
MRSYAIIGTGALGGYYGAKLQQAGLDVHFLLNTDYEYVNLNGLIVESPTGDFTLPCVKAYNDTAKMPACDVVIVALKTTHNYLLPKILPNVVKDDGVVLVLQNGLGVEEEVADIVGADRVIGGLCFLCSNKVAPGHIRHLDYGEIKLGEYVPDYQVVGISERMRQIKSDFDSTGIPILLAEDLLLARWQKLVWNIPYNGLSVVLDALTDELMADPHARVLVEQLMQEVVAGAAACGRIISDSFIQKMLDYTVKTKPYRTSMKIDYEERRSLEVETMFGNPLRAAQKVGVNLPKTAMLYQQLKFLDARNSQKK
>NC_019753.1|WP_015205071.1|4719612_4720614_+|ABC-transporter-ATP-binding-protein
MKSFTDSPLYEPGRGAIVHVERPPVVETYQLRKVYRTGFWLNQKIESLKSCTMTVYQGETFGLLGPNGAGKTTLLKTLLGIVRPTSGRASLLGHPIGDRAVKQSIGYLPENPYFYDYLTGWEFLEFAAGLFEIPPSVQRQRIPELLELVGLAQSAAKKKQMRQYSKGMLQRVGMAQALINNPEVVFLDEPMSGLDPMGRRQMRELILSLKYAGKTVFFNSHVLTEVEQICDRVAILAKGELICAGSLEQLLGVNQDIYQVKGIGGNPDILKRWVRDFTFDDEGWYGQLQGEPQEFLATLRLIGAQLISMQLSRPSLEEFFMQQLLKRGITQSS
>NC_019753.1|WP_015205072.1|4720901_4721318_+|fasciclin-domain-containing-protein
MPNLVDTAANAGSFNTLLTAIKTAGLLEILTSPGPYTVLAPTDEAFAKIPVDTLSGWLQDIPKLKKILTFHILFGDVRTDNFAELDSAETFEGGIIGIEKADGGFKINDAKVLQTDILADNGVIHTIDTVLMPTLMTV
>NC_019753.1|WP_015205073.1|4721434_4722892_-|DUF3459-domain-containing-protein
MEIQTPDWVKHAVFYQIFPDRFARSKHPQKRILTTARWEDWNAMPTLQGYKGGDLWGVIEQLDYLQELGINAIYFTPIFQSASNHRYHTHDYYTVDPMLGGNAGFRELLDAAHERNIKVVLDGVFNHSSRGFFFFHDVLENGPHSPWVNWFKVHDWPLSAYNGDFPANYEGWDGNRALPVFNHENPEVREYIMEIAEYWIKFGVDGWRLDVPFEIKVPGFWQEFRDRVKAINPDAYIVGEVWTDAREWLDGTQFDGVMNYLFAAPTIAFTAGDRVDIEQVQDRSYHPYPPLFASEYAQKITDVLELYPWEIQLTQLNLLASHDTARLLSIAGGDRASVELATLLLLTFPGAPSIYYGDEVGLPGRLDPDSRRGFPLEANWDREILELHRQLIALRHEYTALRTGKYEVLFAEGTVYVFARTWGEEEVIVAVNVGTEAAHSNFVVSKLRSQPSKLLFGSAEVSWNNEGESHQLDLRLPPRSGCILG

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Crispr_ID: NC_019753_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_019753_20

5029582-5031781

TypeV-U4

I-D,II-B

Consensus_repeat	Method
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	PILER-CR
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CRISPRCasFinder
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CRT

30 spacers

The CRISPR arrays of NC_019753_20

>merge|NC_019753|20|5029582-5031781|PILER-CR,CRISPRCasFinder,CRT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACAAAAAACAGTTCCCACCAATAGCAGTAATAGCAGGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACATCTCTAGCCCAAGAGAAGCCAGCCATCCAATCACACCGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACCAGAAATTACGACAGACGCGCAAGCAGGATCAGCCAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACAGCCAGATAATGATGATAATGCTAGAGGCTGTCCGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACGCTGCTTTTTTATTGATAGTTCTTGATCTTCCATGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACAAAAAATTAACTATTTACTTAAAAGTTAATTTTTTAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACTTGAATTCTTGTTGTGTCATAACCAAGGTGGCTATGGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACAGATAGTAATAATGAACTTTTAAGCAGTGGCAAATAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACAATTTCTTCAATACGCTCCCCCATCTGGCGTAATGAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACATGGAAGAGTATAAAGCCAAGGATGGCAAGATGAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACTCGCCAGTTTGATTAATCAAAAAACTCCGGTCGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACTAAGTGTCTAAACTCTATCCCTAATTCTTCTAGTTGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACTCTCTATTGATAAAATCCACTCGATTAATTGCTTCAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACCAGACCTCCCCGACGAGACAGCATACTCAGAGGGAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACATCAAAACTTACTGGTAGCAGCTAAGGAACTATGGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACTACGAGAATCCTCTAACCATTCACCGTGGCTTGTAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACGAATTGTGATCGGCGTTGATACAAAGCTTTGAAAACGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACAGCATCTTCTGGATGTGAGCGTTTAAATTCCGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACTTTTACCTTTTACTTTGACGCTAGAAGGTTGCCGTGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACGAGGGATAGTAAATCCTCCTCAGTTAAATCGTATAAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACTCATTAGACTTTCATACAAGTGAAGTTTTAAATAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACACATACAAAGGCATTAGCTGGTGGTACTACTAATGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACCCCTTATTAACTCTCTTTCAAACTGTGCAATAGCGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACGTAACATTTAAACGCCATACCATGCTCCTGGATCAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACTGAAGCTTTATTAATATCATGCACAATCAAAGCAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACCTGATGTAGTATTTCTTAAGCAATTAAATTATGGCTATAGGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACGTTTATTGCGATCGCCTTTACATTTTTCTAGGGGAAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACAAATGATTTAGTTATAGATGAAAATGTATCTCAGGCGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACGGTTCTGGTGCAGTTTCCATGCGATCGCTAATCGAGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAACGGTTGAGTGAATAGTGATAGTTGCATAATTATTCGCGTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC

>NC_019753|20|8|5029582-5031781|PILER-CR
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AAAAAACAGTTCCCACCAATAGCAGTAATAGCAG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ATCTCTAGCCCAAGAGAAGCCAGCCATCCAATCACACC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CAGAAATTACGACAGACGCGCAAGCAGGATCAGCCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AGCCAGATAATGATGATAATGCTAGAGGCTGTCC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GCTGCTTTTTTATTGATAGTTCTTGATCTTCCAT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AAAAAATTAACTATTTACTTAAAAGTTAATTTTTTA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TTGAATTCTTGTTGTGTCATAACCAAGGTGGCTATG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AGATAGTAATAATGAACTTTTAAGCAGTGGCAAATA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AATTTCTTCAATACGCTCCCCCATCTGGCGTAATGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ATGGAAGAGTATAAAGCCAAGGATGGCAAGATGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TCGCCAGTTTGATTAATCAAAAAACTCCGGTC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TAAGTGTCTAAACTCTATCCCTAATTCTTCTAGTT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TCTCTATTGATAAAATCCACTCGATTAATTGCTTCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CAGACCTCCCCGACGAGACAGCATACTCAGAGGGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ATCAAAACTTACTGGTAGCAGCTAAGGAACTATG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TACGAGAATCCTCTAACCATTCACCGTGGCTTGTA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GAATTGTGATCGGCGTTGATACAAAGCTTTGAAAAC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AGCATCTTCTGGATGTGAGCGTTTAAATTCC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TTTTACCTTTTACTTTGACGCTAGAAGGTTGCCGT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GAGGGATAGTAAATCCTCCTCAGTTAAATCGTATAA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TCATTAGACTTTCATACAAGTGAAGTTTTAAATA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ACATACAAAGGCATTAGCTGGTGGTACTACTAAT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CCCTTATTAACTCTCTTTCAAACTGTGCAATAGC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GTAACATTTAAACGCCATACCATGCTCCTGGATCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TGAAGCTTTATTAATATCATGCACAATCAAAGCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CTGATGTAGTATTTCTTAAGCAATTAAATTATGGCTATAG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GTTTATTGCGATCGCCTTTACATTTTTCTAGGGGAA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AAATGATTTAGTTATAGATGAAAATGTATCTCAGGC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GGTTCTGGTGCAGTTTCCATGCGATCGCTAATCGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GGTTGAGTGAATAGTGATAGTTGCATAATTATTCGC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC

>NC_019753|20|17|5029582-5031781|CRISPRCasFinder
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AAAAAACAGTTCCCACCAATAGCAGTAATAGCAG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ATCTCTAGCCCAAGAGAAGCCAGCCATCCAATCACACC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CAGAAATTACGACAGACGCGCAAGCAGGATCAGCCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AGCCAGATAATGATGATAATGCTAGAGGCTGTCC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GCTGCTTTTTTATTGATAGTTCTTGATCTTCCAT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AAAAAATTAACTATTTACTTAAAAGTTAATTTTTTA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TTGAATTCTTGTTGTGTCATAACCAAGGTGGCTATG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AGATAGTAATAATGAACTTTTAAGCAGTGGCAAATA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AATTTCTTCAATACGCTCCCCCATCTGGCGTAATGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ATGGAAGAGTATAAAGCCAAGGATGGCAAGATGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TCGCCAGTTTGATTAATCAAAAAACTCCGGTC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TAAGTGTCTAAACTCTATCCCTAATTCTTCTAGTT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TCTCTATTGATAAAATCCACTCGATTAATTGCTTCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CAGACCTCCCCGACGAGACAGCATACTCAGAGGGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ATCAAAACTTACTGGTAGCAGCTAAGGAACTATG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TACGAGAATCCTCTAACCATTCACCGTGGCTTGTA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GAATTGTGATCGGCGTTGATACAAAGCTTTGAAAAC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AGCATCTTCTGGATGTGAGCGTTTAAATTCC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TTTTACCTTTTACTTTGACGCTAGAAGGTTGCCGT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GAGGGATAGTAAATCCTCCTCAGTTAAATCGTATAA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TCATTAGACTTTCATACAAGTGAAGTTTTAAATA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ACATACAAAGGCATTAGCTGGTGGTACTACTAAT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CCCTTATTAACTCTCTTTCAAACTGTGCAATAGC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GTAACATTTAAACGCCATACCATGCTCCTGGATCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TGAAGCTTTATTAATATCATGCACAATCAAAGCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CTGATGTAGTATTTCTTAAGCAATTAAATTATGGCTATAG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GTTTATTGCGATCGCCTTTACATTTTTCTAGGGGAA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AAATGATTTAGTTATAGATGAAAATGTATCTCAGGC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GGTTCTGGTGCAGTTTCCATGCGATCGCTAATCGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GGTTGAGTGAATAGTGATAGTTGCATAATTATTCGC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC

>NC_019753|20|6|5029582-5031781|CRT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AAAAAACAGTTCCCACCAATAGCAGTAATAGCAG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ATCTCTAGCCCAAGAGAAGCCAGCCATCCAATCACACC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CAGAAATTACGACAGACGCGCAAGCAGGATCAGCCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AGCCAGATAATGATGATAATGCTAGAGGCTGTCC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GCTGCTTTTTTATTGATAGTTCTTGATCTTCCAT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AAAAAATTAACTATTTACTTAAAAGTTAATTTTTTA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TTGAATTCTTGTTGTGTCATAACCAAGGTGGCTATG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AGATAGTAATAATGAACTTTTAAGCAGTGGCAAATA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AATTTCTTCAATACGCTCCCCCATCTGGCGTAATGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ATGGAAGAGTATAAAGCCAAGGATGGCAAGATGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TCGCCAGTTTGATTAATCAAAAAACTCCGGTC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TAAGTGTCTAAACTCTATCCCTAATTCTTCTAGTT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TCTCTATTGATAAAATCCACTCGATTAATTGCTTCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CAGACCTCCCCGACGAGACAGCATACTCAGAGGGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ATCAAAACTTACTGGTAGCAGCTAAGGAACTATG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TACGAGAATCCTCTAACCATTCACCGTGGCTTGTA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GAATTGTGATCGGCGTTGATACAAAGCTTTGAAAAC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AGCATCTTCTGGATGTGAGCGTTTAAATTCC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TTTTACCTTTTACTTTGACGCTAGAAGGTTGCCGT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GAGGGATAGTAAATCCTCCTCAGTTAAATCGTATAA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TCATTAGACTTTCATACAAGTGAAGTTTTAAATA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	ACATACAAAGGCATTAGCTGGTGGTACTACTAAT
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CCCTTATTAACTCTCTTTCAAACTGTGCAATAGC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GTAACATTTAAACGCCATACCATGCTCCTGGATCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	TGAAGCTTTATTAATATCATGCACAATCAAAGCA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	CTGATGTAGTATTTCTTAAGCAATTAAATTATGGCTATAG
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GTTTATTGCGATCGCCTTTACATTTTTCTAGGGGAA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	AAATGATTTAGTTATAGATGAAAATGTATCTCAGGC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GGTTCTGGTGCAGTTTCCATGCGATCGCTAATCGA
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC	GGTTGAGTGAATAGTGATAGTTGCATAATTATTCGC
GTTTAAATGCACCTAAATCCCTTTTAGGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_019753.1\|WP_041226909.1\|5038020_5039394_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|223714
NC_019753.1\|WP_051035471.1\|5042584_5042863_-\|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl\|CDD\|376620
NC_019753.1\|WP_015205341.1\|5041424_5042588_+\|DUF1822-family-protein	unknown	unknown	gnl\|CDD\|370155
NC_019753.1\|WP_015205329.1\|5022011_5023730_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|226179
NC_019753.1\|WP_015205330.1\|5023743_5024154_+\|DUF962-domain-containing-protein	unknown	unknown	gnl\|CDD\|377609
NC_019753.1\|WP_015205335.1\|5028612_5029314_-\|peptidase-M15	unknown	unknown	gnl\|CDD\|225084
NC_019753.1\|WP_015205337.1\|5032535_5037815_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NC_019753.1\|WP_015205331.1\|5024204_5025062_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238882
NC_019753.1\|WP_015205334.1\|5028081_5028447_-\|DUF3110-domain-containing-protein	unknown	unknown	gnl\|CDD\|371489
NC_019753.1\|WP_015205345.1\|5044043_5044337_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|224937
NC_019753.1\|WP_015205339.1\|5039607_5039961_-\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015205328.1\|5021511_5021832_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NC_019753.1\|WP_015205336.1\|5032025_5032457_+\|hypothetical-protein	unknown	unknown	unknown
NC_019753.1\|WP_015205340.1\|5040151_5041345_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_019753.1\|WP_015205333.1\|5027140_5028085_-\|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl\|CDD\|235467
NC_019753.1\|WP_041226161.1\|5025511_5027044_-\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|100081
NC_019753.1\|WP_157462369.1\|5042912_5043620_+\|phosphatidate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|223248
NC_019753.1\|WP_015205327.1\|5020244_5021495_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133045
NC_019753.1\|WP_015205346.1\|5044326_5044575_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|376852
NC_019753.1\|WP_157462368.1\|5025323_5025464_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_019753.1\|WP_041226909.1\|5038020_5039394_-\|radical-SAM-protein	gnl\|CDD\|223714	COG0641, AslB, Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only].	2.23313e-70
NC_019753.1\|WP_051035471.1\|5042584_5042863_-\|membrane-protein-insertion-efficiency-factor-YidD	gnl\|CDD\|376620	pfam01809, Haemolytic, Haemolytic domain. This domain has haemolytic activity. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	3.66857e-43
NC_019753.1\|WP_015205341.1\|5041424_5042588_+\|DUF1822-family-protein	gnl\|CDD\|370155	pfam08852, DUF1822, Protein of unknown function (DUF1822). This family of proteins are functionally uncharacterized.	6.63345e-111
NC_019753.1\|WP_015205329.1\|5022011_5023730_+\|amidohydrolase-family-protein	gnl\|CDD\|226179	COG3653, COG3653, N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism].	4.37e-104
NC_019753.1\|WP_015205330.1\|5023743_5024154_+\|DUF962-domain-containing-protein	gnl\|CDD\|377609	pfam06127, DUF962, Protein of unknown function (DUF962). This family consists of several eukaryotic and prokaryotic proteins of unknown function. The yeast protein YGL010W has been found to be non-essential for cell growth.	3.42758e-06
NC_019753.1\|WP_015205335.1\|5028612_5029314_-\|peptidase-M15	gnl\|CDD\|225084	COG2173, DdpX, D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane].	2.63631e-66
NC_019753.1\|WP_015205337.1\|5032535_5037815_-\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	4.12477e-108
NC_019753.1\|WP_015205331.1\|5024204_5025062_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238882	cd01846, fatty_acyltransferase_like, Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases. Might catalyze fatty acid transfer between phosphatidylcholine and sterols.	3.56535e-78
NC_019753.1\|WP_015205334.1\|5028081_5028447_-\|DUF3110-domain-containing-protein	gnl\|CDD\|371489	pfam11360, DUF3110, Protein of unknown function (DUF3110). This family of proteins has no known function.	1.54015e-51
NC_019753.1\|WP_015205328.1\|5021511_5021832_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	3.77518e-07
NC_019753.1\|WP_015205345.1\|5044043_5044337_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	6.04466e-15
NC_019753.1\|WP_015205340.1\|5040151_5041345_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.00369e-09
NC_019753.1\|WP_015205333.1\|5027140_5028085_-\|N-acetylmuramic-acid-6-phosphate-etherase	gnl\|CDD\|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	1.89575e-170
NC_019753.1\|WP_041226161.1\|5025511_5027044_-\|site-2-protease-family-protein	gnl\|CDD\|100081	cd06160, S2P-M50_like_2, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with additional putative N- and C-terminal transmembrane spanning regions, relative to the core protein, and no PDZ domains.	3.17455e-46
NC_019753.1\|WP_157462369.1\|5042912_5043620_+\|phosphatidate-cytidylyltransferase	gnl\|CDD\|223248	COG0170, SEC59, Dolichol kinase [Lipid metabolism].	1.89721e-25
NC_019753.1\|WP_015205327.1\|5020244_5021495_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133045	cd06423, CESA_like, CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.	1.97415e-50
NC_019753.1\|WP_015205346.1\|5044326_5044575_-\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	1.70356e-08

>NC_019753.1|WP_015205335.1|5028612_5029314_-|peptidase-M15
MKPYQQISILECGEQLLPIPLEFAIASPHPYIKLGATYGERSPYYLRKGVLEQLTQAQTNLQQQYPGWRIQIFDAYRPVEVQQFMVDYTFNELVQAQNLTSNLSEAQKQAVWQQVEQFWALPSLDPATPPPHSTGAAVDVTLVDSEGEIIDMGGEIDEISERSHPNYYKDATSPTEQQYHTHRQLLQKIMFAAGFQRHPNEWWHFSLGDQMWAWLSNQENPTDLVVARYGRII
>NC_019753.1|WP_015205334.1|5028081_5028447_-|DUF3110-domain-containing-protein
MAALMQVYVLLFNARTENEGIHTIQLGGRNTVLMFESEDDATRFALQLEAQDFPDAAVEAIDREEIEEFCRDADYDCELIEEGMLALPPENSVDETDWQVEGSKPEVSDLDRIRRQLEGLL
>NC_019753.1|WP_015205333.1|5027140_5028085_-|N-acetylmuramic-acid-6-phosphate-etherase
MSNTKNNNNQPLKERGHLLTEQVNPNSQNLDQMNSLELVDLFNTEDQQTLAAIAQSRTQLAETIDRTAQALSRGGRLFYVGAGTSGRLAVLDAAECPPTFCTPPELVQGIIAGGAGALVRSSENLEDRFEDGAEAIAHRHITDLDVVIGITAGGTTPYVHGAVQAARQRGATTALIACVPAEQVSIEADIDIRLLVGPEILAGSTRLKAGTATKMALNIISTGVMVKLGKVYGNRMVDVAVTNTKLHDRALRMLQDLTDLNREDAGYLLERSGRKVKLALLMHWTGVDQEAGEHLLAEHHGNLRLAVEKVQDEK
>NC_019753.1|WP_041226161.1|5025511_5027044_-|site-2-protease-family-protein
MFMTSENTATIIIFLIASGILGLGFYRAKPYGKVGILAWLQSLILMLPWLFLFGSFALGIYLNLVSVVFLLVGSSGLYIFIGNRLRAAGQDVALREKIAERLKANQEVSTPENISPEDITSTQGAASAEGIQEVKAVLPIPDADLKSIQGIFGIDTFFATETIAYQEGAIFKGNLRGEPAATHERLSASLQERMGDRYRLFLVESPEGKPVVVVLPSTNDPQPSTIPQKILAVVLFLATIASSLETAGLFLGFDLSSNVERIKETLPITIGIWVVLASHEIAHRVIAKRHNIRLSLPFFLPSWQIASFGAITRFESLIPNRSVLFDIACSGPAIGGIISFLMLIIGLLLSHPGSLFQLPAQFFQGSILVGTLAKVILGSALQNTIVDIHPLAIIGWLGLVVTALNLMPAGQLDGGRIVQAIYGRKTAQRATIATLIILGIVSIVNPGNPIIFYWVIAILFLQRGLERPSLNEITEPDDARAALGLLALFLMIATLIPLAPGLAGRLGIGG
>NC_019753.1|WP_157462368.1|5025323_5025464_-|hypothetical-protein
MFNYVDIISKVCYMNWVLMLRFFLINLKFKASAIAELRSTTLFYRP
>NC_019753.1|WP_015205331.1|5024204_5025062_-|SGNH/GDSL-hydrolase-family-protein
MVVITKSLQNSHPITELNVFGDSLSDVGTVFRLSGGMYPPNPPYFQGRYSNGLVWVEYLAESLNLSSNQSKNFAYGGATTGKVNPGAAQINYNSLVPDLLTQVKSFTQANQQANLNALYVIWAGANDYLQGVSSEKVPLENLTIAIASLHDFGAKKMLVGNLPDLGHLPATRTNGNSAYLSGLTRAHNQGLRRSLKLISQQRSDLQIATLDANTLYREAITNPAAFGFSNVISGCMAAQTSYSNPDQFLFWDSIHPTTAAHHIIGKTALAAIQDAGIINTTYTHK
>NC_019753.1|WP_015205330.1|5023743_5024154_+|DUF962-domain-containing-protein
MPKITPILHQKLRNKINDQIIEHPFTDYWDIFVLKHQHPINIALHVIGIFIFYGLLFCSWKFHNFWLLFCLPLTQLVGLIGHLLFEQSHIDLIDAVFSWRASSCLGRMLLRIVFGKYKDDIKQRQEILSNYQQNVN
>NC_019753.1|WP_015205329.1|5022011_5023730_+|amidohydrolase-family-protein
MLDLLIQNGLIFDGLGSAPVRGDIGIQNGKIVALPGLGKAISVDAHQVVDASQLWVTPGFIDIHTHYDLELEIAPGLSESVRHGVTSVVIGNCSLSVAVGEPQMLADIFQRVETLSHKLINKWLQKSISWHTPAEYLNHLKQLPLGANVAPMFGHSALRAHVMGLERSLTDQPSETELKTIEQIAVDALDAGFVGISIDMFPWHRMSGEWRGSTIPSQHANFREYAMLADICRQRDVVFQVTPNLQQLTSFLNILRMGLGIGRKPLRLTVLSALDAVHDRRLWRIFSPLLFIWNRILGGNVRFQTLTEPFTIYSDGSVTPLFEEFPTGAQLNSCDSRQERQQLWQSENFRQQFRQEWNSNWRKSFHRQLDLMVIVHCPEKNWEGLSFTEVAHQKQQEPLDFFIEALQNYDTDLRWVATGANDRLEPRLALMQHPDIFPGFTDAGAHVRNLAYYDGALSLLKQAIATNFLSPETAIHRITGEPAQWFRLDTGVLKVGAKADLVLLDPSALNQPISPPVEISDPLLDGEPRMVKRGSDDIVQAVYINGIKVVNQGQVCKNLGQERLGTVLSCGL
>NC_019753.1|WP_015205328.1|5021511_5021832_-|helix-turn-helix-transcriptional-regulator
MELTKKERLEAKDWKVGTVSEFLELTQEESTLIEMKLSLSRSLKERRKRLMTQADLAEKIHSSQPRIAKAENGDSSVSIELLIRAMLATGATPQEIGQAIASSYVE
>NC_019753.1|WP_015205327.1|5020244_5021495_+|glycosyltransferase-family-2-protein
MSGNRSDRRIKATIVVLLVWGIVSLLHWRQSTQWLMVVLTAVLTVQAIRMLIAKPHTTSIDGNSDLLTVSILVPAKNESAVLPNLVHSLFRLDYPTTHLDIWIVDDGSTDATPQILQELQTKFPGLQVHRRESKGGKSGALNAIFPSIKGKIILVCDADAQLPADFLRQTLPLFQQKAIGAVQVRKVIANADTNFLTRCQQMEMSCDAVLQIHRIAAGGMSELRGNGMLIRRELLEKCNGWNEDTVTDDLDLCFRLYLLGTEIEFVTIPSIQEEGVTTWKNLWHQRCRWAEGGYQRYLDYFPEILRLGWAKEIDLLLFFLLQFLLPIGLIPDLLWTIFYSHHPVLLPLQTLLSIILTVAFIGGLAQFQNKRNWSLLWATIQGSLYMVHWIPVMIVTTLSMCVKQPSLNWIKTEHRG
>NC_019753.1|WP_015205336.1|5032025_5032457_+|hypothetical-protein
MNKQVLRIAIALPMVIASANSSLANDTRKPPISNQATIDNIRINGNQQPLFPSTDTRERPKPKGPKGFEVGVQQTPNQQVLGNPANLIERPRPPVPGGTDPGLQQTTQQLLNLPGETRVRPKPKGPGSHDLNLQVVPQQQLQY
>NC_019753.1|WP_015205337.1|5032535_5037815_-|hypothetical-protein
MSPVSIATSRSTQALETGQPKLWLLMVGVNKYQDQTLHSLRYSSVDCQGLAEALLEATQGFAQKEIKIYHDFAPELPYLKTVRASLKQISTAAKSQDTILCYFSGHGMLEPNTQQAYLCLADTQKDNLFNTGLALQELLELLGNCAAHQQLVWLDACHSGGMTLRGITQTAKAEPLLNPASQLVEVLQQRANKTQGFYALLSCDQGQQSWEFPELGHGVFTYYLMRGLRGEAADAQGRIDVDSLYRYVYHQTLQYIDKTNQQLRLINQQKRHKGETQLNPEYPLQSPKRIVEGIGELILGSTPTYGKSRLQRTALVVEGLTSSKITLEFSKVLRGIGGFALEYLPRPGKTTVQDVREAIQKCLRVAGKDAGELLNIKQQYNTEEPTTALLYLRGHLAETEADEAVLLLGEDIIISRSWLRQQLRRSQVIQQIIILDCIDIEQTSSLKEWVEDLQLDAERGQCIIAASPSDNNSEKFAQALLDTIVAPQSSGLSIACWITQLQVFLADAFPLHIWLSGAQGVIEVLPGKTAFQNSDKEGLDLGICPYKGLRAFGEEDAQYFYGRENLTQQLINQVAHKSFLAVVGASGSGKSSVVQAGLIAKLRQGKQFPGSDKWFIRKVTPGIRPLEALSRRLVEGGIDKEKASLQALQIEGMLYQGVEGFVYWIRSRPESMVVLVIDQFEELFTLAPSEDRQRFLELILGAVEYAADKFKLIITLRTDFIAACLEVPKLAMRLQQSNVLVPPKLTADDYRRVIVNPAEQVGLKVANDLVEVLLQELNHSAGDLPLLEFVLEQLWEYRSQGELTLQAYQEQVGGIKGALEQKAQAVYESLDAQAKECARWIFLSLTQLGEGTEDTRRRVFKSDLVVKKYQAALVDRTLQALIAAKLVVVSLEDESRTPPPTHPRPRGGEQEDLSSMKSPSPGFPQGGNELLEEVREESVELSLEVMKQQVTVEVAHEILIRHWSTLRWWLEENRARLRSQRQIAQAALQWKHSGKQSDFLLQGVRLAEAEDIYIKYTDELSADVQEFIAACLEQRQQKQFEQKKRLRQAQKAVVAISVLAIAASGFGGLAYWHSQTAQLREIDALNSSSQANLLLNNQLEALIASVKAAKRLNKTIAIPANLKTETVSTLQQVVTTIQERDRLNGHTDSVISVNYSPDNQLIASASLDKTVKLWSNHGLLLTTLRGHSEAVYSVSFSPDNKILASAGVDKTIKLWNVSDRRLLKTISGHNQTVNSVNFSPDGKIIASSSADQTIKLWQVSDGRLLKTLSGHNAGVISINFSPDGNTIASASEDKIIKLWQVSDAKLLKILTGHTNWVNSVTFNPDGKLIASAGADKTIKLWNSSDGKLIRTISGHNDSVWGVRFSPDSKNMISASRDNTIKLWNLNGIEVETFKGHKKGVYSVSFSPDGKNIASASLDNTIKIWQRRESSLLEILTSGSGVYGASFSPQGDIVASATAEGAILLWRRSDGKFLKTLTGHNKAIYSVSFNPQGNLLASASEDKTVKVWNINHQTLLYTLKGHSDEVNSASFSFDGKMIATASRDRTVKLWDSNNGKLIHTLKGHSDEVYKVSFSPDSETIVTASADKTIKVWNSRTGNLIKSIPAHKDWIYSVNFSPDGKFIASTSADKTIKLWRSSDYYLLHTFKGHQAEVYSSSFAPDSQTFTSASEDKTIKIWQIDGTLLKTIPAHSAAVMSVNFSLDGKSIISGSLDNTAKIWSFDRQQLQASDQKYLMQRACNWLHDYLKTNSQVSRDERKLCSS
>NC_019753.1|WP_041226909.1|5038020_5039394_-|radical-SAM-protein
MKLSYYHVATEPFFDELEKRIKRVIFATRTANVRIIDEFSWNLLESGQFEQLPEDFLIDLANIQLIVSSDEDELKSILAQNDTVAKNDTDLYLVVQPTAYCQLGCHYCGQEHKSKMMSETDQQRFLERTRSKLESGKFSSLSIAWFGAEPLVGLPVIKSLSPQLQALAASFDCSYDAKIVTNGLALTEHVATELIKDFGVSFIEVTLDGVAEYHNARRMQKSGLPTFDKIFTNVTNLARREDLQVQLNIRCNVDYQNYESVSLLLEQLAAEGIQDKIGFYVAPIHSWGNDAHTRSLSKEEFGEWEIAWFGEMVELGFRPILIPDRTPIVCMALMPNSELVDAYGNIFNCSEVSYVPTYGTPNEYAIDHLSGKEMPGKRDRLGNFNQQVRQGEFPCSTCPMLPVCGGGCPKSWLEGIAPCPSAKYNIEDRLLLSYALSRIEQTKETQRAEEENLSVAY
>NC_019753.1|WP_015205339.1|5039607_5039961_-|hypothetical-protein
MSIRNANQLKVLLGIITLTSVAALTPTAYAQVPARANDNILNRANLNTNTIKLDQQNLKLSPSVEQIPGLSKKADSDGNGICNGSCRPKAGRGAELLTNPALESNTKLIQSIRGINR
>NC_019753.1|WP_015205340.1|5040151_5041345_+|sigma-70-family-RNA-polymerase-sigma-factor
MRPRQSIIELFSKFVQFESDRFHAWLTDAKLRRSMETCLNQASDATPSENFWALYWYNLWHSQTSHLAKAHLTAYLQEPCYWTSQKIASAFASTQYTLSDCFQVAIANLDTVLKGFNPSQGFPLKNYAAAIFSSTLHNILRQRQEIDICTDYALLRKLSQKRLVESLQQAGLSQEKIASYVLAWNSFKTVYVPTQATATRKLPAPDQETWNAIANLYNQQRLQQPGVKESNAETLEKWLLACAKAARAYLYPTQISLNAPKSGENAEEFLDSLPETATPSLLTEIIAQEEAQSRAEQLAQINTVLSTALADLDQEAKTILQLYYAQELTQQQIAKQLEIKQYTVSRRLTKTKESLLLALGRWSKEELHISMNSDVLKDISTTIEVWLKLHYVGREIS
>NC_019753.1|WP_015205341.1|5041424_5042588_+|DUF1822-family-protein
MILDTVVFDSTNVRLEFSELEQDQVWQQSQAFSSAFSRWNAYLNQIALKAILPWLREEYLAKANISPASAALPSFWEVVNGTAIVADNTRFVLIPSESIDSSELRVPQEWVDIPSWTADYYLAVQVNSDEKGVVVWGYATHEQLKTRGTYDSSDRTYHLSSENLTLDLNVLWVARQLGIEETTRVPIPSLATLPLTQAQNLIQRLGNPAITLPRLAVPFELWGALLEHGGTRQNLYEKRLGLPQKSIIDWLRSGVSDLAQQIGWGQIELQPSFAGGRGEELTSTKIILSRQLQIAGQNYELRVFPVGNIEDSIWRFELRNSTIGGLIPGGVKLRLLTEDLETFDGNEDIALTAQERLYIDVGLAPEEGIVWETEPLPDNYDREILRF
>NC_019753.1|WP_051035471.1|5042584_5042863_-|membrane-protein-insertion-efficiency-factor-YidD
MKTLIMWLIRGYRSFISPLFLPSCRFQPTCSQYALESVERFGAWRGSWLAVRRILRCHPFHPGGYDPVPLREEGGERREGAEKAEEAEEAGS
>NC_019753.1|WP_157462369.1|5042912_5043620_+|phosphatidate-cytidylyltransferase
MKPLFNSLPWLASIPSLWLQIGIVGVWLGIIVLLAESLHRYTATDPERVRKVVHIGTGNVILFAWWFNLPAWLGITASILASAVALISYKFPILPGINSVGRQSFGTFFYALSIGILVGWFWYLHQPQYAAIGILVMTWGDGLAALIGQRFGKHPYMVWDSKKSWEGSIAMAVVSYVITSLILFGVEGNIWQTWVVSLAVALAATGLESFSKLGIDNFTVPIGSAAVCFFLMQIL
>NC_019753.1|WP_015205345.1|5044043_5044337_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MKNEDSPKQSYLLRIAYTAEKDLKDLQPKQYKQVASKIFSLIRNPKPHDCKALKGEPDGYRVDQGEFRILYYVYEDQKIVDVYRVGKRNDDEVYRNL
>NC_019753.1|WP_015205346.1|5044326_5044575_-|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MTTFTASIARKLFPDLLNRVGFGQERILVERRGKPIAAIVSIQDLQRLEALEDMIDSAALRKAKEENTGFTTLEAITQAREE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_019753_1	1.1\|327839\|30\|NC_019753\|PILER-CR	327839-327868	30	NC_019753.1	738886-738915	0	1.0
NC_019753_1	1.2\|327894\|42\|NC_019753\|PILER-CR	327894-327935	42	NC_019753.1	738819-738860	0	1.0

1. spacer 1.1|327839|30|NC_019753|PILER-CR matches to position: 738886-738915, mismatch: 0, identity: 1.0

aaaattcggcgtaaattttgacgctatggc	CRISPR spacer
aaaattcggcgtaaattttgacgctatggc	Protospacer
******************************

2. spacer 1.2|327894|42|NC_019753|PILER-CR matches to position: 738819-738860, mismatch: 0, identity: 1.0

tgatcaatttcattctctacctaaaatcaagggttctgagct	CRISPR spacer
tgatcaatttcattctctacctaaaatcaagggttctgagct	Protospacer
******************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_019753_18	18.1\|4687038\|25\|NC_019753\|CRISPRCasFinder	4687038-4687062	25	MN693586	Marine virus AFVG_25M48, complete genome	50710-50734	4	0.84
NC_019753_18	18.1\|4687038\|25\|NC_019753\|CRISPRCasFinder	4687038-4687062	25	NZ_CP039845	Acetobacter pasteurianus strain CICC 22518 plasmid pAP22518-1, complete sequence	266680-266704	4	0.84
NC_019753_8	8.1\|1339651\|27\|NC_019753\|CRISPRCasFinder	1339651-1339677	27	CP024913	Cyanobacterium sp. HL-69 plasmid pCHL69-1, complete sequence	77287-77313	6	0.778
NC_019753_8	8.1\|1339651\|27\|NC_019753\|CRISPRCasFinder	1339651-1339677	27	NZ_CP032280	Acinetobacter sp. WCHA55 plasmid p1_010055, complete sequence	23834-23860	6	0.778
NC_019753_2	2.29\|655928\|33\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	655928-655960	33	JX145341	Clostridium phage phiMMP02, complete genome	44903-44935	7	0.788
NC_019753_2	2.29\|655928\|33\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	655928-655960	33	KX228400	Clostridium phage CDKM15, complete genome	47147-47179	7	0.788
NC_019753_6	6.8\|993174\|36\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	993174-993209	36	NZ_CP037748	Campylobacter helveticus strain 2013D-9613 plasmid unnamed2, complete sequence	40240-40275	7	0.806
NC_019753_6	6.8\|993174\|36\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	993174-993209	36	NZ_CP020480	Campylobacter helveticus strain ATCC 51209 plasmid pHELV-2, complete sequence	1113-1148	7	0.806
NC_019753_20	20.18\|5030845\|31\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5030845-5030875	31	NC_048053	Dickeya phage vB_DsoM_JA29, complete genome	84342-84372	7	0.774
NC_019753_20	20.18\|5030845\|31\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5030845-5030875	31	MH389777	Dickeya phage vB_DsoM_JA11, complete genome	83645-83675	7	0.774
NC_019753_20	20.18\|5030845\|31\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5030845-5030875	31	MH460462	Dickeya phage vB_DsoM_JA33, complete genome	83635-83665	7	0.774
NC_019753_20	20.18\|5030845\|31\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5030845-5030875	31	MH460460	Dickeya phage vB_DsoM_JA13, complete genome	83840-83870	7	0.774
NC_019753_1	1.1\|327839\|30\|NC_019753\|PILER-CR	327839-327868	30	NZ_CP016375	Elizabethkingia anophelis strain F3201 plasmid unnamed, complete sequence	33389-33418	8	0.733
NC_019753_2	2.29\|655928\|33\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	655928-655960	33	NZ_CP030933	Enterococcus gilvus strain CR1 plasmid pCR1A, complete sequence	480373-480405	8	0.758
NC_019753_3	3.2\|657440\|34\|NC_019753\|CRISPRCasFinder	657440-657473	34	MN855606	Siphoviridae sp. isolate 42, complete genome	482-515	8	0.765
NC_019753_19	19.3\|4712354\|33\|NC_019753\|PILER-CR	4712354-4712386	33	NZ_CP046705	Nostoc sp. ATCC 53789 plasmid pNsp_b, complete sequence	33769-33801	8	0.758
NC_019753_20	20.4\|5029838\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5029838-5029871	34	NZ_CP007602	Staphylococcus capitis subsp. capitis strain AYP1020 plasmid pAYP1020, complete sequence	29012-29045	8	0.765
NC_019753_20	20.10\|5030272\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5030272-5030305	34	NZ_CP037443	Klebsiella sp. PO552 plasmid p2, complete sequence	78879-78912	8	0.765
NC_019753_20	20.18\|5030845\|31\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5030845-5030875	31	NZ_CP038863	Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence	66706-66736	8	0.742
NC_019753_2	2.28\|655855\|37\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	655855-655891	37	NZ_CP015640	Pseudomonas lurida strain L228 plasmid unnamed, complete sequence	60533-60569	9	0.757
NC_019753_2	2.29\|655928\|33\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	655928-655960	33	CP008938	Candidatus Caedibacter acanthamoebae plasmid Plasmid_00002, complete sequence	55581-55613	9	0.727
NC_019753_6	6.14\|993604\|35\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	993604-993638	35	AJ344259	Sulfolobus virus SIRV-2 genomic DNA	5144-5178	9	0.743
NC_019753_20	20.11\|5030343\|32\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5030343-5030374	32	NZ_LT960613	Vibrio tapetis subsp. tapetis isolate Vibrio tapetis CECT4600 plasmid P, complete sequence	58713-58744	9	0.719
NC_019753_20	20.28\|5031564\|36\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031564-5031599	36	KC821624	Cellulophaga phage phi14:2, complete genome	54655-54690	9	0.75
NC_019753_6	6.4\|992876\|33\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	992876-992908	33	KM359505	Prochlorococcus phage P-TIM68, complete genome	154655-154687	10	0.697
NC_019753_6	6.8\|993174\|36\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	993174-993209	36	MT080596	UNVERIFIED: Staphylococcus phage vB_SauM_EW42, complete genome	133345-133380	10	0.722
NC_019753_6	6.8\|993174\|36\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	993174-993209	36	MT080593	UNVERIFIED: Staphylococcus phage vB_SauM_EW36, complete genome	52079-52114	10	0.722
NC_019753_20	20.21\|5031058\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031058-5031091	34	NC_010901	Lactococcus lactis plasmid pNP40, complete sequence	46201-46234	10	0.706
NC_019753_20	20.21\|5031058\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031058-5031091	34	NZ_CP043527	Lactococcus lactis subsp. lactis bv. diacetylactis strain SD96 plasmid pSD96_03, complete sequence	29621-29654	10	0.706
NC_019753_20	20.21\|5031058\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031058-5031091	34	NZ_CP016707	Lactococcus lactis subsp. cremoris strain UC109 plasmid pUC109A, complete sequence	18398-18431	10	0.706
NC_019753_20	20.21\|5031058\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031058-5031091	34	NZ_CP016702	Lactococcus lactis subsp. lactis strain 275 plasmid p275D, complete sequence	18844-18877	10	0.706
NC_019753_20	20.21\|5031058\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031058-5031091	34	NZ_CP042409	Lactococcus lactis strain CBA3619 plasmid unnamed, complete sequence	105676-105709	10	0.706
NC_019753_20	20.21\|5031058\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031058-5031091	34	NZ_CP016686	Lactococcus lactis subsp. cremoris strain 158 plasmid p158B, complete sequence	16229-16262	10	0.706
NC_019753_20	20.23\|5031200\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031200-5031233	34	NZ_CP049777	Enterococcus faecalis strain ES-1 plasmid unnamed2, complete sequence	46851-46884	10	0.706
NC_019753_20	20.23\|5031200\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031200-5031233	34	MH830362	Enterococcus faecalis plasmid p4, complete sequence	72943-72976	10	0.706
NC_019753_20	20.23\|5031200\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031200-5031233	34	NC_006827	Enterococcus faecalis plasmid pCF10, complete sequence	64820-64853	10	0.706
NC_019753_20	20.23\|5031200\|34\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031200-5031233	34	MH598799	Pelagibacter phage HTVC025P, complete genome	22731-22764	10	0.706
NC_019753_20	20.24\|5031271\|35\|NC_019753\|PILER-CR,CRISPRCasFinder,CRT	5031271-5031305	35	NZ_CP029830	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed1, complete sequence	541035-541069	10	0.714

1. spacer 18.1|4687038|25|NC_019753|CRISPRCasFinder matches to MN693586 (Marine virus AFVG_25M48, complete genome) position: , mismatch: 4, identity: 0.84

accatatcccaatcctcttccagag	CRISPR spacer
aagttatcccaatcctcttccagat	Protospacer
*   ********************

2. spacer 18.1|4687038|25|NC_019753|CRISPRCasFinder matches to NZ_CP039845 (Acetobacter pasteurianus strain CICC 22518 plasmid pAP22518-1, complete sequence) position: , mismatch: 4, identity: 0.84

accatatcccaatcctcttccagag	CRISPR spacer
cccatctcccactcctcttccagaa	Protospacer
 **** ***** ************.

3. spacer 8.1|1339651|27|NC_019753|CRISPRCasFinder matches to CP024913 (Cyanobacterium sp. HL-69 plasmid pCHL69-1, complete sequence) position: , mismatch: 6, identity: 0.778

gtaacgcctccaaatcatcaaactcat	CRISPR spacer
cgcacaaatccaaatcatcaaactcat	Protospacer
   **.  *******************

4. spacer 8.1|1339651|27|NC_019753|CRISPRCasFinder matches to NZ_CP032280 (Acinetobacter sp. WCHA55 plasmid p1_010055, complete sequence) position: , mismatch: 6, identity: 0.778

gtaacgcctccaaatcatcaaactcat	CRISPR spacer
gctcagcctccaaatcatccaactcac	Protospacer
*.   ************** ******.

5. spacer 2.29|655928|33|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to JX145341 (Clostridium phage phiMMP02, complete genome) position: , mismatch: 7, identity: 0.788

ttttttccttatttgcttctaaaaataagtaac	CRISPR spacer
tcatttccttattttcttctaaacataaatcat	Protospacer
*. *********** ******** ****.* *.

6. spacer 2.29|655928|33|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to KX228400 (Clostridium phage CDKM15, complete genome) position: , mismatch: 7, identity: 0.788

ttttttccttatttgcttctaaaaataagtaac	CRISPR spacer
tcatttccttattttcttctaaacataaatcat	Protospacer
*. *********** ******** ****.* *.

7. spacer 6.8|993174|36|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP037748 (Campylobacter helveticus strain 2013D-9613 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.806

agaaatccactaggattatattttttaatagtataa	CRISPR spacer
aaaaaattattaggataaaattttttaatagtataa	Protospacer
*.*** ..*.****** * *****************

8. spacer 6.8|993174|36|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020480 (Campylobacter helveticus strain ATCC 51209 plasmid pHELV-2, complete sequence) position: , mismatch: 7, identity: 0.806

agaaatccactaggattatattttttaatagtataa	CRISPR spacer
aaaaaattattaggataaaattttttaatagtataa	Protospacer
*.*** ..*.****** * *****************

9. spacer 20.18|5030845|31|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NC_048053 (Dickeya phage vB_DsoM_JA29, complete genome) position: , mismatch: 7, identity: 0.774

agcatcttctggatgtgagcgtttaaattcc	CRISPR spacer
ccctttttctggacgtgaccgtttaaattca	Protospacer
  * *.*******.**** ***********

10. spacer 20.18|5030845|31|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to MH389777 (Dickeya phage vB_DsoM_JA11, complete genome) position: , mismatch: 7, identity: 0.774

agcatcttctggatgtgagcgtttaaattcc	CRISPR spacer
ccctttttctggacgtgaccgtttaaattca	Protospacer
  * *.*******.**** ***********

11. spacer 20.18|5030845|31|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to MH460462 (Dickeya phage vB_DsoM_JA33, complete genome) position: , mismatch: 7, identity: 0.774

agcatcttctggatgtgagcgtttaaattcc	CRISPR spacer
ccctttttctggacgtgaccgtttaaattca	Protospacer
  * *.*******.**** ***********

12. spacer 20.18|5030845|31|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to MH460460 (Dickeya phage vB_DsoM_JA13, complete genome) position: , mismatch: 7, identity: 0.774

agcatcttctggatgtgagcgtttaaattcc	CRISPR spacer
ccctttttctggacgtgaccgtttaaattca	Protospacer
  * *.*******.**** ***********

13. spacer 1.1|327839|30|NC_019753|PILER-CR matches to NZ_CP016375 (Elizabethkingia anophelis strain F3201 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

aaaattcggcgtaaattttgacgctatggc	CRISPR spacer
aaaattcggagaaaattttgacggatttat	Protospacer
********* * ***********   * ..

14. spacer 2.29|655928|33|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030933 (Enterococcus gilvus strain CR1 plasmid pCR1A, complete sequence) position: , mismatch: 8, identity: 0.758

ttttttccttatttgcttctaaaaataagtaac	CRISPR spacer
gtttttccttatttgccactaaaaatagaaaga	Protospacer
 ***************. *********.. *.

15. spacer 3.2|657440|34|NC_019753|CRISPRCasFinder matches to MN855606 (Siphoviridae sp. isolate 42, complete genome) position: , mismatch: 8, identity: 0.765

gtgaatctttttttttggccagcttcc---agtttac	CRISPR spacer
cacaagctttctttttggccagcttcctttagtt---	Protospacer
   ** ****.****************   ****

16. spacer 19.3|4712354|33|NC_019753|PILER-CR matches to NZ_CP046705 (Nostoc sp. ATCC 53789 plasmid pNsp_b, complete sequence) position: , mismatch: 8, identity: 0.758

atcggggcttttggctgtggtaaatctttattt	CRISPR spacer
ttagaagcttttgcttgtggtaaatctttatac	Protospacer
 * *..******* .**************** .

17. spacer 20.4|5029838|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007602 (Staphylococcus capitis subsp. capitis strain AYP1020 plasmid pAYP1020, complete sequence) position: , mismatch: 8, identity: 0.765

agccag---ataatgatgataatgctagaggctgtcc	CRISPR spacer
---cagataataatgatgataatgatacaggctatga	Protospacer
   ***   *************** ** *****.*

18. spacer 20.10|5030272|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP037443 (Klebsiella sp. PO552 plasmid p2, complete sequence) position: , mismatch: 8, identity: 0.765

atggaagag-tataaagccaaggatggcaagatga	CRISPR spacer
-taaaggaaccataaggctaaggatggcaagatga	Protospacer
 *..*.**. .****.**.****************

19. spacer 20.18|5030845|31|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP038863 (Campylobacter jejuni strain SCJK2 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.742

agcatcttctggatgtgagcgtttaaattcc	CRISPR spacer
agcattttctggaggtgagcgtttttctcat	Protospacer
*****.******* **********   *. .

20. spacer 2.28|655855|37|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015640 (Pseudomonas lurida strain L228 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.757

gtaggatctgcaacagcattagcgggaggatgtcaat	CRISPR spacer
ccaggatctgcaacagcattagcgtcaggaggcattt	Protospacer
 .**********************  **** *.   *

21. spacer 2.29|655928|33|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to CP008938 (Candidatus Caedibacter acanthamoebae plasmid Plasmid_00002, complete sequence) position: , mismatch: 9, identity: 0.727

ttttttccttatttgcttctaaaaataagtaac-----	CRISPR spacer
ttgtttccttagttgcttctaaaa-----tattctttt	Protospacer
** ******** ************     ** .

22. spacer 6.14|993604|35|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to AJ344259 (Sulfolobus virus SIRV-2 genomic DNA) position: , mismatch: 9, identity: 0.743

gttaggggttttttctcatgaattattcctttttt	CRISPR spacer
tctttcacttttttctcataaaatattcctttttt	Protospacer
 .*   . ***********.** ************

23. spacer 20.11|5030343|32|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LT960613 (Vibrio tapetis subsp. tapetis isolate Vibrio tapetis CECT4600 plasmid P, complete sequence) position: , mismatch: 9, identity: 0.719

tcgccagtttgattaatcaaaaaactccggtc	CRISPR spacer
cctacagtatgagtaatcaaaaaactccaaaa	Protospacer
.*  **** *** ***************..

24. spacer 20.28|5031564|36|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to KC821624 (Cellulophaga phage phi14:2, complete genome) position: , mismatch: 9, identity: 0.75

aaatgatttagttatagatgaaaatgtatctcaggc	CRISPR spacer
tactaatgtagttatagatgaaaatatatctaactt	Protospacer
 * *.** *****************.***** *  .

25. spacer 6.4|992876|33|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to KM359505 (Prochlorococcus phage P-TIM68, complete genome) position: , mismatch: 10, identity: 0.697

ttaaagaaccatcaggattagtagtttttacag	CRISPR spacer
agtcataatcatcaggattattagtttttaatc	Protospacer
    * **.*********** *********

26. spacer 6.8|993174|36|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to MT080596 (UNVERIFIED: Staphylococcus phage vB_SauM_EW42, complete genome) position: , mismatch: 10, identity: 0.722

agaaatcc---actaggattatattttttaatagtataa	CRISPR spacer
---tactcataactaggattatattttttaagtgtatct	Protospacer
    *..*   ********************  ****

27. spacer 6.8|993174|36|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to MT080593 (UNVERIFIED: Staphylococcus phage vB_SauM_EW36, complete genome) position: , mismatch: 10, identity: 0.722

agaaatcc---actaggattatattttttaatagtataa	CRISPR spacer
---tactcataactaggattatattttttaagtgtatct	Protospacer
    *..*   ********************  ****

28. spacer 20.21|5031058|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NC_010901 (Lactococcus lactis plasmid pNP40, complete sequence) position: , mismatch: 10, identity: 0.706

tcattagactttcatacaagtgaagttttaaata	CRISPR spacer
aaaccaatatttaatgcaagtgaagttttaaatg	Protospacer
  *..*.  *** **.*****************.

29. spacer 20.21|5031058|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP043527 (Lactococcus lactis subsp. lactis bv. diacetylactis strain SD96 plasmid pSD96_03, complete sequence) position: , mismatch: 10, identity: 0.706

tcattagactttcatacaagtgaagttttaaata	CRISPR spacer
aaaccaatatttaatgcaagtgaagttttaaatg	Protospacer
  *..*.  *** **.*****************.

30. spacer 20.21|5031058|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016707 (Lactococcus lactis subsp. cremoris strain UC109 plasmid pUC109A, complete sequence) position: , mismatch: 10, identity: 0.706

tcattagactttcatacaagtgaagttttaaata	CRISPR spacer
aaaccaatatttaatgcaagtgaagttttaaatg	Protospacer
  *..*.  *** **.*****************.

31. spacer 20.21|5031058|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016702 (Lactococcus lactis subsp. lactis strain 275 plasmid p275D, complete sequence) position: , mismatch: 10, identity: 0.706

tcattagactttcatacaagtgaagttttaaata	CRISPR spacer
aaaccaatatttaatgcaagtgaagttttaaatg	Protospacer
  *..*.  *** **.*****************.

32. spacer 20.21|5031058|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP042409 (Lactococcus lactis strain CBA3619 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.706

tcattagactttcatacaagtgaagttttaaata	CRISPR spacer
aaaccaatatttaatgcaagtgaagttttaaatg	Protospacer
  *..*.  *** **.*****************.

33. spacer 20.21|5031058|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP016686 (Lactococcus lactis subsp. cremoris strain 158 plasmid p158B, complete sequence) position: , mismatch: 10, identity: 0.706

tcattagactttcatacaagtgaagttttaaata	CRISPR spacer
aaaccaatatttaatgcaagtgaagttttaaatg	Protospacer
  *..*.  *** **.*****************.

34. spacer 20.23|5031200|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049777 (Enterococcus faecalis strain ES-1 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.706

cccttattaactctctttcaaactgtgcaatagc	CRISPR spacer
tcacgattaaatctctttcaaattgtgcaaagct	Protospacer
.* . ***** ***********.******* . .

35. spacer 20.23|5031200|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to MH830362 (Enterococcus faecalis plasmid p4, complete sequence) position: , mismatch: 10, identity: 0.706

cccttattaactctctttcaaactgtgcaatagc	CRISPR spacer
tcacgattaaatctctttcaaattgtgcaaagct	Protospacer
.* . ***** ***********.******* . .

36. spacer 20.23|5031200|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NC_006827 (Enterococcus faecalis plasmid pCF10, complete sequence) position: , mismatch: 10, identity: 0.706

cccttattaactctctttcaaactgtgcaatagc	CRISPR spacer
tcacgattaaatctctttcaaattgtgcaaagct	Protospacer
.* . ***** ***********.******* . .

37. spacer 20.23|5031200|34|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to MH598799 (Pelagibacter phage HTVC025P, complete genome) position: , mismatch: 10, identity: 0.706

cccttattaactctctttcaaactgtgcaatagc	CRISPR spacer
ttgcttctaaatttctttcaaactgtgcaatatt	Protospacer
.. .* .*** *.******************* .

38. spacer 20.24|5031271|35|NC_019753|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029830 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

gtaacatttaaacgccataccatgctcctggatca	CRISPR spacer
ggcgcggcggaacggcataccatgctcctggacca	Protospacer
*  .*. . .**** *****************.**

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

272982 : 331280

Klosneuvirus(25.0%)

tRNA,integrase,transposase

attL 283829:283857|attR 349928:349956

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015201364.1\|272982_274533_-\|tRNA	lysine--tRNA ligase	A0A1V0SIS0	Klosneuvirus	7.9e-79	37.7
WP_015201365.1\|274804_275650_+	M28 family peptidase	NA	NA	NA	NA
WP_015201366.1\|275950_277276_+	AAA family ATPase	NA	NA	NA	NA
WP_041226202.1\|277450_282526_+	hypothetical protein	NA	NA	NA	NA
WP_015201368.1\|282640_283750_+	ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	1.5e-18	39.6
283829:283857	attL	NA	NA	NA	NA
WP_157462219.1\|283858_284623_-	hypothetical protein	NA	NA	NA	NA
WP_015201370.1\|284532_285693_-	hypothetical protein	NA	NA	NA	NA
WP_015201371.1\|285868_286342_-	hypothetical protein	NA	NA	NA	NA
WP_015201372.1\|286503_287040_-	hypothetical protein	NA	NA	NA	NA
WP_015201373.1\|287316_288372_-	S-methyl-5-thioribose-1-phosphate isomerase	NA	NA	NA	NA
WP_015201374.1\|288452_290363_-	1-deoxy-D-xylulose-5-phosphate synthase	NA	NA	NA	NA
WP_015201375.1\|290569_290839_-	hypothetical protein	NA	NA	NA	NA
WP_157462385.1\|291098_292763_+	nucleoside:proton symporter	NA	NA	NA	NA
WP_015201377.1\|293038_293743_+	glycoside hydrolase family 104 protein	A0A0A0P1Q4	Enterobacteria_phage	4.6e-18	41.9
WP_015201378.1\|294012_294681_+	type 1 glutamine amidotransferase domain-containing protein	NA	NA	NA	NA
WP_015201379.1\|294934_296491_-	gamma-glutamyltransferase	NA	NA	NA	NA
WP_015201380.1\|296510_297065_-	hypothetical protein	NA	NA	NA	NA
WP_157462220.1\|297169_299356_+	PAS domain S-box protein	NA	NA	NA	NA
WP_157462221.1\|299579_299894_-	hypothetical protein	NA	NA	NA	NA
WP_015201382.1\|299871_301293_-	vanadium-dependent haloperoxidase	A0A1V0SKZ4	Klosneuvirus	5.6e-31	30.3
WP_015201383.1\|302072_302627_+	ferric reductase	NA	NA	NA	NA
WP_015201384.1\|302697_304116_+	WD40 repeat domain-containing protein	NA	NA	NA	NA
WP_015201385.1\|304184_304502_-	hypothetical protein	NA	NA	NA	NA
WP_015201386.1\|304703_305402_+	NGG1p interacting factor 3 protein, NIF3	NA	NA	NA	NA
WP_015201387.1\|305741_306158_+	peptidoglycan-binding protein	NA	NA	NA	NA
WP_015201388.1\|306376_306871_+	peptide-methionine (R)-S-oxide reductase MsrB	NA	NA	NA	NA
WP_015201389.1\|306958_307741_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_015201390.1\|308087_308342_-	hypothetical protein	NA	NA	NA	NA
WP_015201391.1\|308494_309442_+	alpha/beta hydrolase	A0A167RJ59	Powai_lake_megavirus	2.4e-46	37.9
WP_083890012.1\|309589_310177_+	hypothetical protein	NA	NA	NA	NA
WP_015201328.1\|310138_311347_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A0H3UZC2	Geobacillus_virus	4.0e-78	45.7
WP_015201392.1\|312946_314278_+	TldD/PmbA family protein	NA	NA	NA	NA
WP_015201393.1\|314677_316396_+	phosphodiesterase	NA	NA	NA	NA
WP_157462386.1\|316482_317139_-	DUF3120 domain-containing protein	NA	NA	NA	NA
WP_157462387.1\|317611_318550_+	undecaprenyl-diphosphate phosphatase	NA	NA	NA	NA
WP_012411495.1\|318845_319091_+	photosystem I iron-sulfur center protein PsaC	C7EDU4	uncultured_marine_virus	5.3e-22	92.6
WP_015201396.1\|319346_321245_+	glutamine--fructose-6-phosphate transaminase (isomerizing)	A7IW18	Paramecium_bursaria_Chlorella_virus	3.7e-110	39.1
WP_015201397.1\|321771_322023_-	hypothetical protein	NA	NA	NA	NA
WP_015201398.1\|322248_323055_+\|transposase	heteromeric transposase endonuclease subunit TnsA	NA	NA	NA	NA
WP_157462222.1\|323088_323247_+	hypothetical protein	NA	NA	NA	NA
WP_051035311.1\|323314_325246_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_015201399.1\|325235_326834_+	AAA family ATPase	NA	NA	NA	NA
WP_015201400.1\|326848_327748_+\|transposase	transposase	NA	NA	NA	NA
WP_041225819.1\|328100_328412_-	hypothetical protein	NA	NA	NA	NA
WP_015201401.1\|328431_329106_+	plasmid pRiA4b ORF-3 family protein	NA	NA	NA	NA
WP_015201402.1\|329102_330521_+\|transposase	ISKra4-like element ISCep1 family transposase	NA	NA	NA	NA
WP_015201403.1\|330647_331280_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
349928:349956	attR	NA	NA	NA	NA

DBSCAN-SWA_2

463266 : 513697

Pectobacterium_phage(14.29%)

integrase,protease,transposase

attL 484077:484096|attR 517239:517258

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_157462228.1\|463266_463479_+\|transposase	transposase	NA	NA	NA	NA
WP_015201501.1\|463813_464497_+	hypothetical protein	NA	NA	NA	NA
WP_015201503.1\|465625_465943_+	hypothetical protein	NA	NA	NA	NA
WP_015201504.1\|466095_466395_+	hypothetical protein	NA	NA	NA	NA
WP_015201505.1\|466515_466845_+	hypothetical protein	NA	NA	NA	NA
WP_015201506.1\|466845_468855_-	hypothetical protein	NA	NA	NA	NA
WP_015201507.1\|468982_469483_+	DUF1273 family protein	A0A1P8L625	Pectobacterium_phage	7.3e-34	49.1
WP_015201508.1\|469856_470618_+	ParA family protein	Q8JL10	Natrialba_phage	1.8e-15	30.8
WP_015201509.1\|470618_471605_+	ParB/RepB/Spo0J family partition protein	A0A1C9EHY8	Gordonia_phage	7.2e-09	36.8
WP_015201510.1\|471668_471911_+	hypothetical protein	NA	NA	NA	NA
WP_015201511.1\|472021_472420_+	hypothetical protein	NA	NA	NA	NA
WP_015201512.1\|472472_473252_-	hypothetical protein	NA	NA	NA	NA
WP_083890044.1\|473248_474004_-	mobilization protein MobD	NA	NA	NA	NA
WP_015201514.1\|474633_475092_-	hypothetical protein	NA	NA	NA	NA
WP_015201515.1\|475091_476321_-	ParM/StbA family protein	NA	NA	NA	NA
WP_157462229.1\|476746_476947_+	hypothetical protein	NA	NA	NA	NA
WP_015201516.1\|477008_477395_+	hypothetical protein	NA	NA	NA	NA
WP_015201517.1\|477626_477938_+	hypothetical protein	NA	NA	NA	NA
WP_051035327.1\|478996_479338_-	hypothetical protein	NA	NA	NA	NA
WP_015201518.1\|479521_480628_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_051035328.1\|480599_481007_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_015201519.1\|481583_482411_+	hypothetical protein	NA	NA	NA	NA
WP_015201520.1\|482561_482969_-	hypothetical protein	NA	NA	NA	NA
WP_157462391.1\|483774_484266_+	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
484077:484096	attL	NA	NA	NA	NA
WP_157462392.1\|484433_484967_+	hypothetical protein	NA	NA	NA	NA
WP_015201523.1\|485278_485692_+	XisH protein	NA	NA	NA	NA
WP_015201524.1\|485679_486042_+	XisI protein	NA	NA	NA	NA
WP_015201525.1\|486101_486437_+	hypothetical protein	NA	NA	NA	NA
WP_083890046.1\|486854_488153_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_015201527.1\|489367_489748_-\|protease	clan AA aspartic protease	NA	NA	NA	NA
WP_015201528.1\|489744_490017_-	hypothetical protein	NA	NA	NA	NA
WP_051035329.1\|490252_491707_+	DNA polymerase III subunit beta	R9TRR6	Rhizobium_phage	1.7e-14	25.5
WP_015201529.1\|491678_492785_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_083890015.1\|492783_493056_+	hypothetical protein	NA	NA	NA	NA
WP_015201530.1\|493143_494541_+	DNA polymerase III subunit gamma/tau	A0A1L2BWV7	Bacteriophage	7.4e-52	37.5
WP_015201531.1\|494537_495491_+	DNA polymerase III subunit delta	NA	NA	NA	NA
WP_157462231.1\|495644_495863_+	hypothetical protein	NA	NA	NA	NA
WP_015201532.1\|495985_496387_+	hypothetical protein	NA	NA	NA	NA
WP_015201533.1\|496506_496875_+	hypothetical protein	NA	NA	NA	NA
WP_015201534.1\|496892_497603_+	uracil-DNA glycosylase	NA	NA	NA	NA
WP_015201535.1\|497586_497985_-	hypothetical protein	NA	NA	NA	NA
WP_015201536.1\|498120_498765_+	hypothetical protein	NA	NA	NA	NA
WP_015201537.1\|498815_500795_-	type IV secretory system conjugative DNA transfer family protein	NA	NA	NA	NA
WP_157462393.1\|501182_502151_+	hypothetical protein	NA	NA	NA	NA
WP_015201539.1\|502360_502540_+	hypothetical protein	NA	NA	NA	NA
WP_015201540.1\|502563_502743_+	hypothetical protein	NA	NA	NA	NA
WP_015201541.1\|502839_503574_-	hypothetical protein	NA	NA	NA	NA
WP_157462394.1\|503575_505399_-	M23 family peptidase	NA	NA	NA	NA
WP_041225841.1\|505795_506143_+	hypothetical protein	NA	NA	NA	NA
WP_015201544.1\|506244_506622_-	hypothetical protein	NA	NA	NA	NA
WP_015180083.1\|506899_507349_-	hypothetical protein	NA	NA	NA	NA
WP_157462388.1\|508689_509019_+	hypothetical protein	NA	NA	NA	NA
WP_015201545.1\|509278_509890_+	class I SAM-dependent methyltransferase	A0A2I7RNS1	Vibrio_phage	2.2e-24	36.3
WP_041225843.1\|510246_511578_+	hypothetical protein	NA	NA	NA	NA
WP_015201547.1\|511735_512578_+	hypothetical protein	NA	NA	NA	NA
WP_015201548.1\|512611_513697_+\|integrase	tyrosine-type recombinase/integrase	A0A1B0T6A8	Bacillus_phage	3.5e-09	33.7
517239:517258	attR	NA	NA	NA	NA

DBSCAN-SWA_3

548288 : 584897

uncultured_Mediterranean_phage(33.33%)

integrase,protease,transposase

attL 571553:571567|attR 588059:588073

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015179980.1\|548288_549188_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_051035332.1\|551762_552074_+	M15 family metallopeptidase	NA	NA	NA	NA
WP_015201581.1\|552108_552459_+	hypothetical protein	NA	NA	NA	NA
WP_083890046.1\|552475_553774_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_015201582.1\|554159_554672_-	hypothetical protein	NA	NA	NA	NA
WP_015201583.1\|554935_557587_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_015201584.1\|557854_561433_-\|protease	serine protease	NA	NA	NA	NA
WP_015201585.1\|561567_562128_-	hypothetical protein	NA	NA	NA	NA
WP_015201586.1\|562230_562416_-	hypothetical protein	NA	NA	NA	NA
WP_015201587.1\|562632_563775_-\|protease	serine protease	A0A1B1IRD3	uncultured_Mediterranean_phage	7.8e-07	30.8
WP_157462238.1\|563915_564137_-	hypothetical protein	NA	NA	NA	NA
WP_041226258.1\|565543_567091_-	redoxin domain-containing protein	NA	NA	NA	NA
WP_015201591.1\|567716_569495_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.6e-25	25.0
WP_015201592.1\|569491_570766_+	nucleotidyltransferase family protein	NA	NA	NA	NA
WP_015201593.1\|570784_572185_+	tetratricopeptide repeat protein	A0A2H4UTU3	Bodo_saltans_virus	1.3e-35	29.2
571553:571567	attL	NA	NA	NA	NA
WP_015201594.1\|573252_573960_+	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	1.8e-14	39.8
WP_015201595.1\|573961_574708_+	NAD(P)-dependent oxidoreductase	A0A1V0SKV4	Klosneuvirus	2.7e-08	25.8
WP_083890046.1\|575143_576442_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_015201596.1\|576458_576842_-	hypothetical protein	NA	NA	NA	NA
WP_015201597.1\|576862_577279_-	PIN domain-containing protein	NA	NA	NA	NA
WP_015201598.1\|577265_577523_-	DUF2281 domain-containing protein	NA	NA	NA	NA
WP_015201601.1\|577886_581780_-	N-6 DNA methylase	A0A1B1IUC6	uncultured_Mediterranean_phage	2.3e-50	24.8
WP_015201602.1\|581776_583261_-	AAA family ATPase	NA	NA	NA	NA
WP_083890048.1\|583250_584897_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
588059:588073	attR	NA	NA	NA	NA

DBSCAN-SWA_4

705439 : 739903

Bacillus_phage(50.0%)

integrase,transposase

attL 725518:725532|attR 744443:744457

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015201693.1\|705439_706546_-\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_041225895.1\|706577_707399_+	hypothetical protein	NA	NA	NA	NA
WP_015201694.1\|707515_709063_+	hypothetical protein	A7KV72	Bacillus_phage	1.2e-34	32.6
WP_157462256.1\|709074_709623_+	WGR domain-containing protein	NA	NA	NA	NA
WP_015201696.1\|709726_709999_-	hypothetical protein	NA	NA	NA	NA
WP_041225897.1\|710313_711414_+	SAM-dependent methyltransferase	A8HNV9	Thalassomonas_phage	6.7e-40	40.8
WP_015201698.1\|711523_711916_+	hypothetical protein	NA	NA	NA	NA
WP_015201699.1\|711993_713448_-	hypothetical protein	NA	NA	NA	NA
WP_015201700.1\|713743_714661_+	phage Gp37/Gp68 family protein	U5XHW5	Phormidium_phage	1.4e-54	42.4
WP_015201701.1\|714812_715322_+	hypothetical protein	NA	NA	NA	NA
WP_015201702.1\|715458_715659_+	hypothetical protein	NA	NA	NA	NA
WP_015201703.1\|715798_716059_+	hypothetical protein	NA	NA	NA	NA
WP_015201704.1\|716249_716531_+	hypothetical protein	NA	NA	NA	NA
WP_015201705.1\|716918_717224_+	hypothetical protein	NA	NA	NA	NA
WP_015201706.1\|717449_717695_+	hypothetical protein	NA	NA	NA	NA
WP_015201707.1\|717738_717981_+	hypothetical protein	NA	NA	NA	NA
WP_015201708.1\|718068_718398_+	hypothetical protein	NA	NA	NA	NA
WP_041226286.1\|721812_722124_+	hypothetical protein	NA	NA	NA	NA
WP_015201711.1\|722467_723550_+\|integrase	tyrosine-type recombinase/integrase	A0A0S2GLI2	Bacillus_phage	2.4e-10	32.6
WP_015201712.1\|723554_725438_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_015201713.1\|725421_726450_+	hypothetical protein	NA	NA	NA	NA
725518:725532	attL	NA	NA	NA	NA
WP_015201714.1\|726492_726972_+	hypothetical protein	NA	NA	NA	NA
WP_015201715.1\|727528_728311_-	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
WP_015201716.1\|728466_728886_-	hypothetical protein	NA	NA	NA	NA
WP_015201717.1\|729113_729653_-	hypothetical protein	NA	NA	NA	NA
WP_015201718.1\|730415_730868_+	hypothetical protein	NA	NA	NA	NA
WP_157462257.1\|730938_731502_+	hypothetical protein	NA	NA	NA	NA
WP_015201720.1\|731660_731981_-	hypothetical protein	NA	NA	NA	NA
WP_083890022.1\|732017_732161_-	ATP-binding cassette domain-containing protein	NA	NA	NA	NA
WP_015201721.1\|732274_732565_+	hypothetical protein	NA	NA	NA	NA
WP_015201722.1\|732780_733020_+	hypothetical protein	NA	NA	NA	NA
WP_015201724.1\|733412_734408_-	hypothetical protein	NA	NA	NA	NA
WP_015201725.1\|734460_734769_+	hypothetical protein	NA	NA	NA	NA
WP_015201727.1\|735471_735849_+	hypothetical protein	NA	NA	NA	NA
WP_157462258.1\|735920_736103_+	hypothetical protein	NA	NA	NA	NA
WP_157462259.1\|736380_736539_-	hypothetical protein	NA	NA	NA	NA
WP_157462398.1\|736673_737738_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_157462260.1\|738241_738799_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_015201400.1\|739003_739903_-\|transposase	transposase	NA	NA	NA	NA
744443:744457	attR	NA	NA	NA	NA

DBSCAN-SWA_5

2310007 : 2356873

Bacillus_phage(13.33%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015203025.1\|2310007_2311894_-\|protease	ATP-dependent zinc metalloprotease FtsH	G9E4U6	Ostreococcus_lucimarinus_virus	7.8e-129	50.2
WP_015203026.1\|2312675_2313932_-	ferredoxin--NADP(+) reductase	NA	NA	NA	NA
WP_015203027.1\|2314265_2314433_-	hypothetical protein	NA	NA	NA	NA
WP_157462307.1\|2315220_2315580_+	hypothetical protein	NA	NA	NA	NA
WP_015203030.1\|2315667_2316126_+	peptidase	NA	NA	NA	NA
WP_015203031.1\|2316166_2316952_-	adenosylcobinamide-GDP ribazoletransferase	NA	NA	NA	NA
WP_015203032.1\|2317181_2317631_+	hypothetical protein	NA	NA	NA	NA
WP_015203033.1\|2317821_2318958_+\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.6e-74	40.3
WP_015203034.1\|2319004_2319142_+	photosystem II reaction center protein K	NA	NA	NA	NA
WP_015203035.1\|2319342_2319900_-	glutathione S-transferase family protein	NA	NA	NA	NA
WP_015203036.1\|2319916_2320381_-	hypothetical protein	NA	NA	NA	NA
WP_015203037.1\|2320723_2321116_-	hypothetical protein	NA	NA	NA	NA
WP_015203038.1\|2321342_2321438_-	photosystem I reaction center subunit XII	NA	NA	NA	NA
WP_015203039.1\|2321698_2322454_+	DUF475 domain-containing protein	S5MAL1	Bacillus_phage	1.9e-22	32.6
WP_041226544.1\|2322515_2322965_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	5.9e-27	42.7
WP_015203041.1\|2323062_2324130_-	D-alanine--D-alanine ligase	NA	NA	NA	NA
WP_015203042.1\|2324221_2325418_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	D9J0Y9	Brochothrix_phage	7.7e-74	41.1
WP_015203043.1\|2325909_2327286_-\|tRNA	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	NA	NA	NA	NA
WP_041226008.1\|2327477_2327786_-	mechanosensitive ion channel	NA	NA	NA	NA
WP_015203044.1\|2327846_2329280_-	hypothetical protein	NA	NA	NA	NA
WP_015203045.1\|2329430_2332265_+	PAS domain-containing protein	W8CYF6	Bacillus_phage	8.4e-26	31.5
WP_015203046.1\|2332380_2332836_-	lactoylglutathione lyase	NA	NA	NA	NA
WP_157462308.1\|2333048_2334338_+	phosphopyruvate hydratase	W6LP63	Streptococcus_phage	3.0e-132	57.4
WP_015203048.1\|2334522_2335767_-\|transposase	transposase	A0A1L2BWT9	Bacteriophage	1.6e-34	57.7
WP_015203049.1\|2335971_2337030_-	N-acetyl-gamma-glutamyl-phosphate reductase	NA	NA	NA	NA
WP_015203050.1\|2337257_2338946_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase RibB/GTP cyclohydrolase II RibA	A0A2H4PQS2	Staphylococcus_phage	8.9e-100	47.5
WP_015203051.1\|2338942_2339974_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_015203052.1\|2339973_2340282_+	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_015203053.1\|2340522_2341245_+	pyridoxine 5'-phosphate synthase	NA	NA	NA	NA
WP_015203054.1\|2341270_2341600_+	DUF2488 family protein	NA	NA	NA	NA
WP_083890060.1\|2341703_2342408_+	hypothetical protein	NA	NA	NA	NA
WP_041226550.1\|2342435_2342891_-	divergent PAP2 family protein	NA	NA	NA	NA
WP_015203057.1\|2342925_2343864_-	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_041226009.1\|2343966_2344845_-	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	3.9e-30	36.8
WP_015203059.1\|2344943_2345414_+	hypothetical protein	NA	NA	NA	NA
WP_015203060.1\|2345410_2345854_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_015203061.1\|2345940_2346798_-	hypothetical protein	NA	NA	NA	NA
WP_157462425.1\|2347088_2349755_+	DNA mismatch repair protein MutS	A0A1V0SJ67	Klosneuvirus	1.3e-41	23.1
WP_015203063.1\|2349853_2350084_-	hypothetical protein	NA	NA	NA	NA
WP_015203064.1\|2350234_2350453_-	type II toxin-antitoxin system HicB family antitoxin	G9BWD3	Planktothrix_phage	1.8e-29	86.1
WP_015203065.1\|2350786_2351152_-\|protease	clan AA aspartic protease	NA	NA	NA	NA
WP_015203066.1\|2351148_2351421_-	hypothetical protein	NA	NA	NA	NA
WP_157462309.1\|2351551_2351737_+	hypothetical protein	NA	NA	NA	NA
WP_015203068.1\|2351844_2353164_-	serine/threonine protein kinase	S4W2F5	Pandoravirus	2.6e-06	29.5
WP_015203069.1\|2353312_2354515_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_041226010.1\|2354810_2355023_+	hypothetical protein	NA	NA	NA	NA
WP_015203071.1\|2355157_2355553_-\|transposase	IS200/IS605 family transposase	Q332K6	Clostridium_botulinum_C_phage	5.0e-30	49.2
WP_015203072.1\|2355607_2356873_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1L2BWW3	Bacteriophage	4.2e-163	66.7

DBSCAN-SWA_6

4081153 : 4125722

Microcystis_virus(20.0%)

integrase,transposase

attL 4093884:4093905|attR 4111984:4112005

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_157462346.1\|4081153_4081510_-\|transposase	IS200/IS605 family transposase	A0A7E6	Microcystis_virus	2.0e-25	49.2
WP_015204566.1\|4082776_4083964_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A068A1P5	Thermus_phage	6.5e-49	33.4
WP_015204567.1\|4084013_4085057_-	hemerythrin	NA	NA	NA	NA
WP_015204568.1\|4085271_4086309_-	hemerythrin	NA	NA	NA	NA
WP_015204569.1\|4086814_4087558_+	DUF2993 domain-containing protein	NA	NA	NA	NA
WP_015204570.1\|4087668_4088187_+	DUF2231 domain-containing protein	NA	NA	NA	NA
WP_015204571.1\|4088415_4088838_-	hypothetical protein	NA	NA	NA	NA
WP_015204572.1\|4089014_4089308_+	DUF2809 domain-containing protein	NA	NA	NA	NA
WP_015204573.1\|4089404_4090319_-	metallophosphoesterase	NA	NA	NA	NA
WP_015204574.1\|4090765_4091863_+	hypothetical protein	NA	NA	NA	NA
WP_015204575.1\|4091943_4092636_-	N-acetylmannosamine-6-phosphate 2-epimerase	NA	NA	NA	NA
WP_015204576.1\|4092872_4093334_+	hypothetical protein	NA	NA	NA	NA
WP_015204577.1\|4093701_4097691_+	cobaltochelatase subunit CobN	NA	NA	NA	NA
4093884:4093905	attL	NA	NA	NA	NA
WP_015204578.1\|4097687_4098479_-	hypothetical protein	NA	NA	NA	NA
WP_015204579.1\|4098493_4098973_-	hypothetical protein	NA	NA	NA	NA
WP_015204580.1\|4099233_4101057_-	HAMP domain-containing protein	NA	NA	NA	NA
WP_041226793.1\|4101053_4101992_-	phosphate/phosphite/phosphonate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_015179980.1\|4105031_4105931_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_015179979.1\|4106012_4106480_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_083890034.1\|4106507_4106744_-\|transposase	IS200/IS605 family transposase	A0A1S5RHE3	Helicobacter_phage	1.8e-11	47.0
WP_015204582.1\|4106786_4108034_+\|transposase	transposase	A0A0P0ICY9	Lactobacillus_phage	8.8e-20	27.0
WP_157462462.1\|4108081_4109521_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_015204584.1\|4109919_4112964_-	exonuclease subunit SbcC	G3MAB6	Bacillus_virus	9.3e-23	33.7
4111984:4112005	attR	NA	NA	NA	NA
WP_015204585.1\|4113285_4113690_+	hypothetical protein	NA	NA	NA	NA
WP_157462347.1\|4113962_4114586_+	hypothetical protein	NA	NA	NA	NA
WP_015204587.1\|4114928_4115495_-	hypothetical protein	NA	NA	NA	NA
WP_015204588.1\|4115643_4116096_-	nitrate reductase maturation protein NarM	NA	NA	NA	NA
WP_041226794.1\|4116119_4116575_-	membrane protein	NA	NA	NA	NA
WP_015204590.1\|4116595_4118845_-	nitrate reductase	NA	NA	NA	NA
WP_015204591.1\|4119242_4120751_-	NarK family nitrate/nitrite MFS transporter	NA	NA	NA	NA
WP_015204592.1\|4120850_4122827_-	ferredoxin--nitrite reductase	NA	NA	NA	NA
WP_015204593.1\|4123358_4124693_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_015204594.1\|4124828_4125722_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA

DBSCAN-SWA_7

4641174 : 4694588

Nostoc_phage(20.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_083890046.1\|4641174_4642473_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_157462358.1\|4642555_4643464_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_015205007.1\|4644088_4645567_+	leucyl aminopeptidase	Q6GYZ8	Mycoplasma_phage	6.0e-52	37.9
WP_015205008.1\|4645683_4646748_-	LOG family protein	NA	NA	NA	NA
WP_157462359.1\|4646939_4648091_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A191SB13	Nostoc_phage	1.2e-180	81.8
WP_015205009.1\|4648494_4648821_-	thioredoxin	A0A1J0GW78	Streptomyces_phage	2.1e-21	47.6
WP_015205010.1\|4649129_4650293_-	GuaB3 family IMP dehydrogenase-related protein	A0A1B1IS93	uncultured_Mediterranean_phage	4.8e-12	33.3
WP_051035415.1\|4650438_4651026_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_015205011.1\|4651626_4652178_+	hypothetical protein	NA	NA	NA	NA
WP_041226136.1\|4652266_4652515_+	hypothetical protein	NA	NA	NA	NA
WP_015205012.1\|4652529_4652730_+	hypothetical protein	NA	NA	NA	NA
WP_083890037.1\|4652680_4653001_+	hypothetical protein	NA	NA	NA	NA
WP_015205013.1\|4653095_4653311_+	hypothetical protein	NA	NA	NA	NA
WP_015205014.1\|4653307_4653592_+	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	NA	NA	NA	NA
WP_083890046.1\|4655655_4656954_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_051035416.1\|4656984_4657848_+	hypothetical protein	NA	NA	NA	NA
WP_041226137.1\|4657945_4658536_+	DUF3038 domain-containing protein	NA	NA	NA	NA
WP_015205016.1\|4658649_4660488_+	DUF4335 domain-containing protein	NA	NA	NA	NA
WP_015205017.1\|4660732_4661047_-	carbon dioxide-concentrating mechanism protein CcmK	NA	NA	NA	NA
WP_015205018.1\|4661192_4661402_-	hypothetical protein	NA	NA	NA	NA
WP_015205019.1\|4661466_4661949_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_015205020.1\|4661967_4663131_-	formate-dependent phosphoribosylglycinamide formyltransferase	NA	NA	NA	NA
WP_015205021.1\|4663446_4663830_+	DUF4112 domain-containing protein	NA	NA	NA	NA
WP_015205022.1\|4663960_4664380_-	peptidylprolyl isomerase	A0A076FI46	Aureococcus_anophage	6.8e-17	42.4
WP_015205023.1\|4664521_4666459_-	ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	5.0e-54	28.9
WP_015205024.1\|4666758_4668681_+	serine/threonine protein kinase	A0A1V0SBL0	Catovirus	1.1e-08	22.5
WP_015205025.1\|4668799_4669480_+	ATP-dependent dethiobiotin synthetase BioD	NA	NA	NA	NA
WP_015205026.1\|4669525_4670755_+	amidohydrolase	NA	NA	NA	NA
WP_015205027.1\|4670930_4671485_-	DNA starvation/stationary phase protection protein	NA	NA	NA	NA
WP_015205028.1\|4671826_4672069_+	hypothetical protein	NA	NA	NA	NA
WP_015205029.1\|4672156_4672813_+	hypothetical protein	NA	NA	NA	NA
WP_015205030.1\|4672972_4673788_-	phosphonate ABC transporter, permease protein PhnE	NA	NA	NA	NA
WP_015205031.1\|4673957_4674692_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	6.5e-23	34.2
WP_083890038.1\|4674699_4675512_-	PhnD/SsuA/transferrin family substrate-binding protein	NA	NA	NA	NA
WP_083890046.1\|4675726_4677025_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_015205032.1\|4677041_4677197_-	hypothetical protein	NA	NA	NA	NA
WP_015205033.1\|4677590_4678727_-	endoribonuclease L-PSP	NA	NA	NA	NA
WP_015205034.1\|4678872_4679304_-	NUDIX hydrolase	NA	NA	NA	NA
WP_015205035.1\|4679501_4681007_+	4-alpha-glucanotransferase	NA	NA	NA	NA
WP_015205036.1\|4681070_4681895_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015205037.1\|4681891_4682677_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_157462360.1\|4682748_4683486_+	DUF2993 domain-containing protein	NA	NA	NA	NA
WP_015205039.1\|4683525_4684404_-	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_015205040.1\|4684510_4685113_-	precorrin-6Y C5,15-methyltransferase subunit CbiT	NA	NA	NA	NA
WP_015205041.1\|4685165_4686701_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_015205042.1\|4686972_4687203_+	hypothetical protein	NA	NA	NA	NA
WP_015205043.1\|4687238_4688330_+	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_015205044.1\|4688402_4689059_-	hypothetical protein	NA	NA	NA	NA
WP_015205045.1\|4689299_4689827_+	hypothetical protein	NA	NA	NA	NA
WP_157462470.1\|4690044_4690506_-	hypothetical protein	NA	NA	NA	NA
WP_015205047.1\|4690746_4691097_+	hypothetical protein	NA	NA	NA	NA
WP_015205048.1\|4691175_4692687_+	AAA family ATPase	U5XJW0	Phormidium_phage	1.0e-99	39.5
WP_015205049.1\|4692817_4693171_+	DUF1257 domain-containing protein	NA	NA	NA	NA
WP_015205050.1\|4693364_4694588_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A191SB13	Nostoc_phage	2.7e-151	66.7

DBSCAN-SWA_8

4698168 : 4763221

Bacillus_phage(20.0%)

holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041226862.1\|4698168_4698582_+\|transposase	IS200/IS605 family transposase	A0A7E6	Microcystis_virus	1.2e-29	47.4
WP_015205055.1\|4698718_4701115_-	NACHT domain-containing NTPase	NA	NA	NA	NA
WP_015205056.1\|4701274_4705618_+	PAS domain S-box protein	A0A1V0SGX0	Hokovirus	2.2e-57	38.5
WP_041226138.1\|4705614_4705896_+	response regulator	W8CYM9	Bacillus_phage	1.7e-08	40.3
WP_083890046.1\|4705920_4707219_-\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_071881132.1\|4707397_4707646_+	response regulator	NA	NA	NA	NA
WP_015205057.1\|4707930_4708248_+	hypothetical protein	NA	NA	NA	NA
WP_015205058.1\|4708404_4708740_-	ribulose bisphosphate carboxylase small subunit	NA	NA	NA	NA
WP_015205059.1\|4708786_4709197_-	chaperonin family protein RbcX	NA	NA	NA	NA
WP_015205060.1\|4709289_4710720_-	form I ribulose bisphosphate carboxylase large subunit	NA	NA	NA	NA
WP_015205061.1\|4711217_4711991_+	3-methyl-2-oxobutanoate hydroxymethyltransferase	NA	NA	NA	NA
WP_015205062.1\|4712469_4712670_+	type II toxin-antitoxin system HicA family toxin	A0A1L2JY37	Aeribacillus_phage	4.5e-11	54.4
WP_015205063.1\|4712659_4712878_+	HicB family protein	A0A0A7S1E5	Clostridium_phage	1.6e-06	49.2
WP_015205064.1\|4712966_4714730_-	serine/threonine protein kinase	NA	NA	NA	NA
WP_015205065.1\|4714972_4715494_-	DUF937 domain-containing protein	NA	NA	NA	NA
WP_015205066.1\|4715664_4717224_+	DUF697 domain-containing protein	NA	NA	NA	NA
WP_015205067.1\|4717414_4717990_+	Uma2 family endonuclease	NA	NA	NA	NA
WP_015205069.1\|4718310_4719249_-	putative 2-dehydropantoate 2-reductase	NA	NA	NA	NA
WP_015205071.1\|4719612_4720614_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.6e-30	39.2
WP_015205072.1\|4720901_4721318_+	fasciclin domain-containing protein	NA	NA	NA	NA
WP_015205073.1\|4721434_4722892_-	DUF3459 domain-containing protein	NA	NA	NA	NA
WP_015205074.1\|4723514_4723913_+	response regulator transcription factor	NA	NA	NA	NA
WP_041226140.1\|4723997_4724177_-	hypothetical protein	NA	NA	NA	NA
WP_015205076.1\|4724219_4724480_-	hypothetical protein	NA	NA	NA	NA
WP_015205077.1\|4724685_4725240_+	DUF2854 domain-containing protein	NA	NA	NA	NA
WP_015205078.1\|4725412_4725670_-	chlororespiratory reduction protein 7	NA	NA	NA	NA
WP_015205079.1\|4725751_4727191_+	YdiU family protein	A0A075BSJ0	Microcystis_phage	9.1e-170	61.6
WP_015205080.1\|4727238_4727949_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_051035467.1\|4728131_4728773_+	VanW family protein	NA	NA	NA	NA
WP_015205082.1\|4728882_4731534_-	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	1.5e-114	33.8
WP_083890071.1\|4731864_4732959_-\|transposase	transposase	A0A1V0S8G3	Catovirus	6.1e-25	31.2
WP_015205084.1\|4732936_4733512_-\|transposase	IS607 family transposase	A7RAM3	Paramecium_bursaria_Chlorella_virus	5.2e-36	44.3
WP_015205085.1\|4733553_4733883_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015205086.1\|4733925_4734267_-	hypothetical protein	NA	NA	NA	NA
WP_015205087.1\|4734337_4738660_-	response regulator	W8CYF6	Bacillus_phage	7.5e-26	34.5
WP_015205088.1\|4738769_4741043_-	PAS domain S-box protein	W8CYF6	Bacillus_phage	1.3e-24	32.3
WP_071881134.1\|4741097_4741292_-	hypothetical protein	NA	NA	NA	NA
WP_015205089.1\|4741487_4741853_+	DUF1830 domain-containing protein	NA	NA	NA	NA
WP_015205090.1\|4741909_4742212_+	hypothetical protein	NA	NA	NA	NA
WP_157462361.1\|4742274_4742475_+	hypothetical protein	NA	NA	NA	NA
WP_015205091.1\|4742485_4743172_-	response regulator transcription factor	NA	NA	NA	NA
WP_015205092.1\|4743375_4744953_+	NAD(P)H-quinone oxidoreductase subunit N	NA	NA	NA	NA
WP_015205093.1\|4745251_4745578_-	hypothetical protein	NA	NA	NA	NA
WP_015205094.1\|4745815_4748140_+	hypothetical protein	NA	NA	NA	NA
WP_015205095.1\|4748341_4749628_+	ATP-binding protein	NA	NA	NA	NA
WP_015205096.1\|4749620_4750226_+	RloB domain-containing protein	NA	NA	NA	NA
WP_015205097.1\|4750435_4751275_-	hypothetical protein	NA	NA	NA	NA
WP_041226142.1\|4751271_4752333_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_015205098.1\|4752668_4754714_-	restriction endonuclease subunit M	A0A142K7G3	Mycobacterium_phage	4.0e-38	29.0
WP_015205099.1\|4754927_4756907_+	precorrin-3B C(17)-methyltransferase	NA	NA	NA	NA
WP_015205100.1\|4756994_4757342_-\|holin	phage holin family protein	NA	NA	NA	NA
WP_015205101.1\|4757434_4758562_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_015205102.1\|4759016_4760288_+	insulinase family protein	G3MBJ8	Bacillus_virus	1.4e-33	25.7
WP_015205103.1\|4760355_4761660_+	insulinase family protein	NA	NA	NA	NA
WP_015205104.1\|4761734_4761896_-	hypothetical protein	NA	NA	NA	NA
WP_015205105.1\|4761925_4763221_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1L2BWT9	Bacteriophage	9.4e-09	34.6

DBSCAN-SWA_9

5309437 : 5315487

Caulobacter_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015205565.1\|5309437_5311195_+\|tRNA	arginine--tRNA ligase	A0A2K9L2F0	Tupanvirus	1.1e-97	37.3
WP_015205567.1\|5311421_5312675_-	stress protein	K4JRX3	Caulobacter_phage	1.1e-33	41.2
WP_015205568.1\|5312798_5313371_-	TerD family protein	K4JRX3	Caulobacter_phage	1.9e-38	44.9
WP_015205569.1\|5313428_5314031_-	TerD family protein	K4JRX3	Caulobacter_phage	2.6e-17	29.2
WP_015205570.1\|5314043_5314619_-	TerD family protein	A0A2I7QY15	Vibrio_phage	6.9e-20	34.0
WP_015205571.1\|5314962_5315487_-	peptide deformylase	A0A1D8KUY1	Synechococcus_phage	2.0e-13	34.6

Anti-CRISPR protein detection

Acr_ID: NC_019753.1|WP_015201706.1|717449_717695_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_019753.1|WP_015201706.1|717449_717695_+|hypothetical-protein

717449_717695_+

81 aa aa

705439-739903

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_019753_1	TypeV	1.1\|327839\|30\|NC_019753\|PILER-CR	327839-327868	30	738915-738886	0
NC_019753_1	TypeV	1.2\|327894\|42\|NC_019753\|PILER-CR	327894-327935	42	738860-738819	0

1. spacer 1.1|327839|30|NC_019753|PILER-CR matches to NC_019753 position: 738915-738886, mismatch: 0

aaaattcggcgtaaattttgacgctatggc	CRISPR spacer
aaaattcggcgtaaattttgacgctatggc	Protospacer
******************************

2. spacer 1.2|327894|42|NC_019753|PILER-CR matches to NC_019753 position: 738860-738819, mismatch: 0

tgatcaatttcattctctacctaaaatcaagggttctgagct	CRISPR spacer
tgatcaatttcattctctacctaaaatcaagggttctgagct	Protospacer
******************************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_019753

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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