CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP032534	Bacillus megaterium NCT-2 plasmid pNCT2_6, complete sequence	0 crisprs	RT	0	1
NZ_CP032531	Bacillus megaterium NCT-2 plasmid pNCT2_3, complete sequence	0 crisprs	RT	0	1
NZ_CP032537	Bacillus megaterium NCT-2 plasmid pNCT2_9, complete sequence	0 crisprs	NA	0	0
NZ_CP032528	Bacillus megaterium NCT-2 plasmid pNCT2_1, complete sequence	0 crisprs	RT	0	1
NZ_CP032530	Bacillus megaterium NCT-2 plasmid pNCT2_2, complete sequence	0 crisprs	RT	0	0
NZ_CP032536	Bacillus megaterium NCT-2 plasmid pNCT2_8, complete sequence	0 crisprs	NA	0	0
NZ_CP032533	Bacillus megaterium NCT-2 plasmid pNCT2_5, complete sequence	0 crisprs	RT,csa3	0	0
NZ_CP032532	Bacillus megaterium NCT-2 plasmid pNCT2_4, complete sequence	0 crisprs	NA	0	0
NZ_CP032529	Bacillus megaterium NCT-2 plasmid pNCT2_10, complete sequence	0 crisprs	NA	0	0
NZ_CP032527	Bacillus megaterium NCT-2 chromosome, complete genome	8 crisprs	cas3,DEDDh,RT,WYL,csa3,DinG,c2c4_V-U1	1	4
NZ_CP032535	Bacillus megaterium NCT-2 plasmid pNCT2_7, complete sequence	0 crisprs	NA	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

34737 : 43751

Bacillus_phage(40.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016763689.1\|34737_35643_+	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	1.4e-19	26.3
WP_100229232.1\|35916_36096_+	hypothetical protein	NA	NA	NA	NA
WP_088568182.1\|36287_36659_+	hypothetical protein	A0A1P8CWP4	Bacillus_phage	2.4e-18	43.4
WP_026106738.1\|36672_37005_+	YolD-like family protein	U3PG23	Staphylococcus_phage	3.1e-09	36.7
WP_016766152.1\|37270_37456_+	hypothetical protein	A0A1P8CWV7	Bacillus_phage	3.8e-12	61.4
WP_016766153.1\|37637_38039_-	transcriptional regulator Spx	M1PLC0	Streptococcus_phage	2.7e-07	30.3
WP_013084404.1\|38601_38811_+	alpha/beta-type small acid-soluble spore protein	A0A1P8CX76	Bacillus_phage	3.4e-17	71.4
WP_129542564.1\|38947_40075_-	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	A0A218MNE0	uncultured_virus	7.5e-87	47.2
WP_129542553.1\|40633_40933_+	hypothetical protein	NA	NA	NA	NA
WP_129542565.1\|40945_42079_+	chromosome partitioning protein ParA	Q0H250	Geobacillus_phage	8.1e-57	34.4
WP_129542566.1\|42075_42771_+	hypothetical protein	Q0H249	Geobacillus_phage	2.0e-34	38.0
WP_129542518.1\|42863_43751_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.2e-42	40.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP032531

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

22147 : 89533

Catovirus(23.08%)

integrase,transposase,coat

attL 34557:34573|attR 76669:76685

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_098622081.1\|22147_22681_+\|coat	spore coat protein X	NA	NA	NA	NA
WP_098622082.1\|22718_23147_+\|coat	spore coat protein	NA	NA	NA	NA
WP_074684248.1\|23525_23960_-	hypothetical protein	NA	NA	NA	NA
WP_129542454.1\|24337_25624_+	glycosyltransferase	NA	NA	NA	NA
WP_074684250.1\|25620_25839_-	hypothetical protein	NA	NA	NA	NA
WP_098979947.1\|25855_26395_-	DUF2642 domain-containing protein	NA	NA	NA	NA
WP_129542455.1\|26681_27401_-	glycosyltransferase	NA	NA	NA	NA
WP_098979948.1\|27719_28790_+	glycosyltransferase	NA	NA	NA	NA
WP_129542456.1\|28834_30082_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_098979950.1\|30661_31387_-	glycosyltransferase	A0A1V0S9B9	Catovirus	2.5e-06	26.4
WP_129542457.1\|31746_32661_-	NAD-dependent epimerase/dehydratase family protein	A0A222YY99	Synechococcus_phage	3.3e-24	25.4
WP_129542458.1\|32885_34103_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_129542459.1\|34234_35146_+	NAD-dependent epimerase/dehydratase family protein	M4QPK0	Synechococcus_phage	2.4e-35	34.0
34557:34573	attL	NA	NA	NA	NA
WP_129542460.1\|35348_35972_+	peptidase	A0A1V0SAM1	Catovirus	1.4e-05	32.0
WP_129542461.1\|36358_36556_+	hypothetical protein	NA	NA	NA	NA
WP_129542462.1\|36793_37618_-	SDR family oxidoreductase	A0A2P1ELT6	Moumouvirus	1.7e-32	34.2
WP_029319771.1\|37618_38605_-	polysaccharide biosynthesis protein	A0A1V0SAI8	Catovirus	1.1e-44	32.3
WP_129542463.1\|38597_39689_-	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	A0A2P1ELS7	Moumouvirus	3.0e-93	47.8
WP_097813204.1\|40108_40804_-	peptidase	NA	NA	NA	NA
WP_129542464.1\|41168_42329_-	peptidase S8	A0A1B0T6A2	Bacillus_phage	2.2e-97	51.2
WP_029319780.1\|43348_43630_+	hypothetical protein	NA	NA	NA	NA
WP_097813202.1\|44228_44804_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_098476442.1\|45872_46805_-\|integrase	tyrosine-type recombinase/integrase	A0A1B1P793	Bacillus_phage	1.8e-30	29.2
WP_129542465.1\|46980_48363_-	replication initiation protein	A0A1V0E006	Clostridioides_phage	1.2e-09	28.3
WP_129542466.1\|49338_50235_+	transcriptional regulator	A0A288WFX2	Bacillus_phage	5.1e-22	29.9
WP_097813199.1\|50438_50729_+	hypothetical protein	NA	NA	NA	NA
WP_129542467.1\|50986_51253_-	hypothetical protein	NA	NA	NA	NA
WP_129542468.1\|51711_52569_+	hypothetical protein	NA	NA	NA	NA
WP_098278583.1\|54648_55341_-	peptidase	NA	NA	NA	NA
WP_098278604.1\|55683_55902_+	hypothetical protein	NA	NA	NA	NA
WP_098321926.1\|56891_57923_-	YheC/YheD family protein	NA	NA	NA	NA
WP_029319807.1\|58067_59297_+	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_029319809.1\|59544_59868_-	hypothetical protein	NA	NA	NA	NA
WP_098278586.1\|60428_61178_-	hypothetical protein	NA	NA	NA	NA
WP_029319813.1\|61325_61538_-	hypothetical protein	NA	NA	NA	NA
WP_074684411.1\|62650_62902_-	hypothetical protein	NA	NA	NA	NA
WP_074684410.1\|63864_63957_+	YjcZ family sporulation protein	NA	NA	NA	NA
WP_081715117.1\|64397_64502_-	YjcZ family sporulation protein	NA	NA	NA	NA
WP_074684408.1\|64819_65029_-	hypothetical protein	NA	NA	NA	NA
WP_129542469.1\|65304_66021_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_097812780.1\|66093_66351_+	hypothetical protein	NA	NA	NA	NA
WP_029319823.1\|67154_67361_+	hypothetical protein	NA	NA	NA	NA
WP_029319824.1\|67787_68030_+	spore germination protein	NA	NA	NA	NA
WP_029319826.1\|68051_68279_+	hypothetical protein	NA	NA	NA	NA
WP_098278590.1\|69142_69706_-	DUF3967 domain-containing protein	NA	NA	NA	NA
WP_129542480.1\|72240_74070_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	6.1e-30	26.5
WP_129542470.1\|75270_75501_+	hypothetical protein	NA	NA	NA	NA
WP_129542471.1\|76141_76498_+	YlbF family regulator	NA	NA	NA	NA
WP_129542472.1\|76707_76980_-\|coat	spore coat protein	NA	NA	NA	NA
76669:76685	attR	NA	NA	NA	NA
WP_081715120.1\|77294_77540_+	hypothetical protein	NA	NA	NA	NA
WP_098278593.1\|78369_79050_-	peptidase	NA	NA	NA	NA
WP_098400043.1\|81273_82011_-	hypothetical protein	NA	NA	NA	NA
WP_129542473.1\|82272_83559_+\|transposase	IS110 family transposase	A0A1X9I5Z0	Streptococcus_phage	3.3e-14	24.0
WP_029319874.1\|84135_84594_+	hypothetical protein	NA	NA	NA	NA
WP_029319876.1\|84727_86224_+	multicopper oxidase domain-containing protein	NA	NA	NA	NA
WP_129542474.1\|86551_87505_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_129542475.1\|87921_88128_-	hypothetical protein	NA	NA	NA	NA
WP_074684415.1\|88430_88643_-	hypothetical protein	NA	NA	NA	NA
WP_116299326.1\|89158_89533_-\|coat	spore coat protein X	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP032528

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

46677 : 107650

Bacillus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_129542382.1\|46677_47385_-\|transposase	IS6 family transposase	A0A077SL39	Escherichia_phage	4.4e-53	50.7
WP_016766728.1\|47496_48462_-	ornithine cyclodeaminase family protein	NA	NA	NA	NA
WP_016766726.1\|49683_50028_-	hypothetical protein	NA	NA	NA	NA
WP_016766724.1\|50277_50736_+	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_016766722.1\|51166_52147_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	3.4e-11	26.9
WP_016766720.1\|52991_53240_-	hypothetical protein	NA	NA	NA	NA
WP_016766718.1\|53948_54800_-	hypothetical protein	NA	NA	NA	NA
WP_016766717.1\|54914_55094_-	hypothetical protein	A0A1P8CWV7	Bacillus_phage	1.7e-09	50.8
WP_016766716.1\|55204_55558_-	hypothetical protein	NA	NA	NA	NA
WP_016766715.1\|55967_56108_+	hypothetical protein	NA	NA	NA	NA
WP_016766713.1\|57162_57807_+	DsbA family protein	NA	NA	NA	NA
WP_016766712.1\|57858_58962_+	NADH:flavin oxidoreductase	NA	NA	NA	NA
WP_016766710.1\|59337_59580_+	hypothetical protein	NA	NA	NA	NA
WP_016766709.1\|59770_60658_-	pyridoxal 5'-phosphate synthase lyase subunit PdxS	NA	NA	NA	NA
WP_016766708.1\|60787_62203_+	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_129542383.1\|62336_62519_+	hypothetical protein	NA	NA	NA	NA
WP_097812912.1\|62828_63014_-	hypothetical protein	NA	NA	NA	NA
WP_047933096.1\|63516_63726_+	alpha/beta-type small acid-soluble spore protein	A0A1P8CX76	Bacillus_phage	3.7e-16	69.8
WP_016766667.1\|64159_64459_+	hypothetical protein	NA	NA	NA	NA
WP_016766666.1\|64471_65605_+	DNA segregation ATPase	Q0H250	Geobacillus_phage	6.2e-57	34.1
WP_016766665.1\|65601_66297_+	hypothetical protein	Q0H249	Geobacillus_phage	5.0e-33	38.3
WP_016766664.1\|66586_66907_+	hypothetical protein	NA	NA	NA	NA
WP_026106771.1\|67402_67975_-	hypothetical protein	NA	NA	NA	NA
WP_016766661.1\|69678_69903_-	helix-turn-helix transcriptional regulator	B3RH35	Bacillus_virus	1.2e-09	43.3
WP_129542384.1\|70703_71597_-	sigma-70 family RNA polymerase sigma factor	Q0SPI3	Clostridium_phage	1.4e-11	29.1
WP_129542385.1\|71803_72592_-	plasmid stabilization protein	NA	NA	NA	NA
WP_129542386.1\|72701_74003_-	replication protein	NA	NA	NA	NA
WP_016766237.1\|74491_75067_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_051045975.1\|75861_76401_-\|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	1.4e-59	65.4
WP_016766236.1\|76393_76567_-\|transposase	transposase	A0A1P8CWP5	Bacillus_phage	8.3e-14	64.3
WP_129542387.1\|77614_77872_+	hypothetical protein	NA	NA	NA	NA
WP_098366853.1\|79067_79505_+	hypothetical protein	NA	NA	NA	NA
WP_057242257.1\|79552_79828_+	hypothetical protein	NA	NA	NA	NA
WP_129542388.1\|80577_82377_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	3.2e-87	37.7
WP_129542406.1\|82572_83856_+	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_129542389.1\|83913_84948_+	hypothetical protein	NA	NA	NA	NA
WP_129542390.1\|85061_86015_+	DUF3991 domain-containing protein	NA	NA	NA	NA
WP_129542391.1\|86007_86646_+	restriction endonuclease	NA	NA	NA	NA
WP_053215328.1\|87084_87645_+	L,D-transpeptidase	NA	NA	NA	NA
WP_047932938.1\|87754_87973_+	hypothetical protein	NA	NA	NA	NA
WP_047932937.1\|88026_88338_+	hypothetical protein	NA	NA	NA	NA
WP_034655538.1\|88534_88816_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A2I7SC16	Paenibacillus_phage	2.8e-11	70.8
WP_047932933.1\|88956_89436_-	hypothetical protein	NA	NA	NA	NA
WP_129542392.1\|90112_90676_-	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_129542393.1\|91531_91759_-	hypothetical protein	NA	NA	NA	NA
WP_129542394.1\|92159_92366_-	hypothetical protein	NA	NA	NA	NA
WP_129542395.1\|92754_93936_+\|transposase	IS256-like element ISBame1 family transposase	A0A220NQR7	Corynebacterium_phage	8.5e-33	27.0
WP_129542396.1\|94378_95056_+	DUF421 domain-containing protein	NA	NA	NA	NA
WP_129542397.1\|95185_95767_-	hypothetical protein	NA	NA	NA	NA
WP_129542398.1\|96048_96747_+	DUF421 domain-containing protein	NA	NA	NA	NA
WP_129542407.1\|97521_98076_-	HPP family protein	NA	NA	NA	NA
WP_129542399.1\|99529_100477_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_129542400.1\|100847_101129_-	exonuclease	NA	NA	NA	NA
WP_043977717.1\|101756_101984_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_129542401.1\|102581_103802_-	NO-inducible flavohemoprotein	NA	NA	NA	NA
WP_129542402.1\|104371_104899_+	adenylate kinase DNA topology modulator	NA	NA	NA	NA
WP_129542298.1\|105081_106232_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	1.6e-47	40.3
WP_087947471.1\|106302_107650_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	4.8e-88	61.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_CP032527

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP032527_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP032527_1

683199-683288

Orphan

Consensus_repeat	Method
GAAAGATGATCAAGCAACAGATGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP032527_1

>merge|NZ_CP032527|1|683199-683288|CRISPRCasFinder
GAAAGATGATCAAGCAACAGATGATCAAGCAACGGACGATCAAAGTTCTGAAGATGACCAAAGCTCTGAAGATGATCAAGCAACAGATGA

>NZ_CP032527|1|1|683199-683288|CRISPRCasFinder
GAAAGATGATCAAGCAACAGATGA	TCAAGCAACGGACGATCAAAGTTCTGAAGATGACCAAAGCTC
TGAAGATGATCAAGCAACAGATGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP032527.2\|WP_016765611.1\|680417_680969_+\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|183137
NZ_CP032527.2\|WP_013059279.1\|679815_680292_+\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NZ_CP032527.2\|WP_013085076.1\|690500_691283_+\|phosphatidylserine-decarboxylase	unknown	unknown	gnl\|CDD\|179544
NZ_CP032527.2\|WP_013085082.1\|683653_683869_-\|DUF2536-family-protein	unknown	unknown	gnl\|CDD\|371221
NZ_CP032527.2\|WP_013059286.1\|673516_673933_+\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|234639
NZ_CP032527.2\|WP_016765612.1\|677691_678954_+\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896
NZ_CP032527.2\|WP_013059285.1\|674087_674372_+\|DUF1292-domain-containing-protein	unknown	unknown	gnl\|CDD\|184235
NZ_CP032527.2\|WP_013059266.1\|689846_690386_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|224104
NZ_CP032527.2\|WP_016765608.1\|684666_685362_+\|5'-methylthioadenosine/S-adenosylhomocysteine-nucleosidase	unknown	unknown	gnl\|CDD\|180148
NZ_CP032527.2\|WP_013059280.1\|678961_679597_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|235492
NZ_CP032527.2\|WP_013059269.1\|688265_688406_+\|YrzI-family-small-protein	unknown	unknown	gnl\|CDD\|312864
NZ_CP032527.2\|WP_016765613.1\|676722_677652_+\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896
NZ_CP032527.2\|WP_016765607.1\|685504_686428_+\|cysteine-synthase-family-protein	unknown	unknown	gnl\|CDD\|107204
NZ_CP032527.2\|WP_016765610.1\|681090_682857_+\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|223839
NZ_CP032527.2\|WP_016765614.1\|674784_675888_+\|endolytic-transglycosylase-MltG	unknown	unknown	gnl\|CDD\|376862
NZ_CP032527.2\|WP_013059283.1\|676069_676726_+\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP032527.2\|WP_013059268.1\|688576_689305_-\|RNA-polymerase-sporulation-sigma-factor-SigK	unknown	unknown	gnl\|CDD\|180266
NZ_CP032527.2\|WP_013085078.1\|687644_687875_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372926
NZ_CP032527.2\|WP_016765609.1\|684007_684649_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP032527.2\|WP_016765606.1\|686429_687563_+\|bifunctional-cystathionine-gamma-lyase/homocysteine-desulfhydrase	unknown	unknown	gnl\|CDD\|181076

Protein	Function_ID	Function_description	E-value
NZ_CP032527.2\|WP_016765611.1\|680417_680969_+\|isochorismatase-family-protein	gnl\|CDD\|183137	PRK11440, PRK11440, putative hydrolase; Provisional.	8.6202e-69
NZ_CP032527.2\|WP_013059279.1\|679815_680292_+\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	3.57405e-81
NZ_CP032527.2\|WP_013085076.1\|690500_691283_+\|phosphatidylserine-decarboxylase	gnl\|CDD\|179544	PRK03140, PRK03140, phosphatidylserine decarboxylase; Provisional.	3.34922e-132
NZ_CP032527.2\|WP_013085082.1\|683653_683869_-\|DUF2536-family-protein	gnl\|CDD\|371221	pfam10750, DUF2536, Protein of unknown function (DUF2536). This family of proteins with unknown function appears to be restricted to Bacillus spp. Structural modelling suggests this domain may bind nucleic acids.	2.31857e-29
NZ_CP032527.2\|WP_013059286.1\|673516_673933_+\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|234639	PRK00109, PRK00109, Holliday junction resolvase RuvX.	2.09351e-62
NZ_CP032527.2\|WP_016765612.1\|677691_678954_+\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	9.45467e-144
NZ_CP032527.2\|WP_013059285.1\|674087_674372_+\|DUF1292-domain-containing-protein	gnl\|CDD\|184235	PRK13678, PRK13678, hypothetical protein; Provisional.	2.08538e-31
NZ_CP032527.2\|WP_013059266.1\|689846_690386_-\|CDP-diacylglycerol--serine-O-phosphatidyltransferase	gnl\|CDD\|224104	COG1183, PssA, Phosphatidylserine synthase [Lipid metabolism].	8.22186e-42
NZ_CP032527.2\|WP_016765608.1\|684666_685362_+\|5'-methylthioadenosine/S-adenosylhomocysteine-nucleosidase	gnl\|CDD\|180148	PRK05584, PRK05584, 5'-methylthioadenosine/adenosylhomocysteine nucleosidase.	1.21104e-129
NZ_CP032527.2\|WP_013059280.1\|678961_679597_+\|uridine-kinase	gnl\|CDD\|235492	PRK05480, PRK05480, uridine/cytidine kinase; Provisional.	1.97165e-138
NZ_CP032527.2\|WP_013059269.1\|688265_688406_+\|YrzI-family-small-protein	gnl\|CDD\|312864	pfam09501, Bac_small_YrzI, Probable sporulation protein (Bac_small_yrzI). Members of this family are very small proteins, about 47 residues each, in the genus Bacillus. Single members are found in Bacillus subtilis and Bacillus halodurans, while arrays of six members in tandem are found in Bacillus cereus and Bacillus anthracis. An EIxxE motif present in most members of this family resembles cleavage sites by the germination protease GPR in a number of small acid-soluble spore proteins (SASP). A role in sporulation is possible.	8.77919e-11
NZ_CP032527.2\|WP_016765613.1\|676722_677652_+\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	1.17595e-106
NZ_CP032527.2\|WP_016765607.1\|685504_686428_+\|cysteine-synthase-family-protein	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	8.59992e-147
NZ_CP032527.2\|WP_016765610.1\|681090_682857_+\|penicillin-binding-protein-2	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	1.80727e-80
NZ_CP032527.2\|WP_016765614.1\|674784_675888_+\|endolytic-transglycosylase-MltG	gnl\|CDD\|376862	pfam02618, YceG, YceG-like family. This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of YceG was solved by X-ray crystallography.	1.52766e-121
NZ_CP032527.2\|WP_013059283.1\|676069_676726_+\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	8.51986e-64
NZ_CP032527.2\|WP_013059268.1\|688576_689305_-\|RNA-polymerase-sporulation-sigma-factor-SigK	gnl\|CDD\|180266	PRK05803, PRK05803, RNA polymerase sporulation sigma factor SigK.	2.45415e-148
NZ_CP032527.2\|WP_013085078.1\|687644_687875_+\|hypothetical-protein	gnl\|CDD\|372926	pfam14143, YrhC, YrhC-like protein. The YrhC-like protein family includes the B. subtilis YrhC protein, which is functionally uncharacterized. YrhC is on the same operon as the MccA and MccB genes, which are involved in the conversion of methionine to cysteine. Expression of this operon is repressed in the presence of sulphate or cysteine. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	1.0396e-13
NZ_CP032527.2\|WP_016765609.1\|684007_684649_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.36606e-10
NZ_CP032527.2\|WP_016765606.1\|686429_687563_+\|bifunctional-cystathionine-gamma-lyase/homocysteine-desulfhydrase	gnl\|CDD\|181076	PRK07671, PRK07671, bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase.	0

>NZ_CP032527.2|WP_016765610.1|681090_682857_+|penicillin-binding-protein-2
MKIIHKRIYITLIFILLLISGLGARLVQLQLVSTESFTDKKINLIEGSVKQRTQEMVVDDGRGKFEDKNGQSLTSITHNRLVLFPFLEKMKWPVQQVSEIVGMQPKELTNRLANAKTPVVITKELSHAQVEKINALKVPGVFGIPLKDERPVPLAEHLIGLEAQSRQIIEEKYRDKLKNGAIKSTTPVGISGMQRAFDEFLLPEQESKLLYHVDRLGGPMFGIDVKYTGTANPYYPVSVRTTLDLSAQELVENTLNHYKLKDGGAVLIDIKNNKVIAMASRPSINKKDPFKKQNGSDSVENRLLTPQTPGSIFKTVTAAAALEQNKIQPSFTYNCDKSIYGNNVEEDHQKGQLTFEESFAQSCNATFAQLAKEMIISNPNTLEQYADKLGLIQPVGWTGDVFHFEHFKQFLGEKSGRVWTNEREKKVTNAVAQTAIGQLDVKVTPLAVANMMATIARGGEKKQVKAVDALEYKNNTSLYTFKEHKLKGDTINKATAASMQQLLKGVVQSEKGTGRRFQTLPYEVAGKSGTAEINVKDDIVNKWFAGYFPADDPKYAMVVVDLNTKSTISPTNSVFYDIVKGMYDLNTR
>NZ_CP032527.2|WP_016765611.1|680417_680969_+|isochorismatase-family-protein
MKDIDFAKTALVLIDLQKGIVPIGGDEIVEKSVQLVNRFREQNGFISFVRVDFQDGKDALTPETDQKPSAPQERPADWAEFDPRLNVQENDYIVTKRQWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQYGYNQIFITDAMATFTKEEHEATLSYIFPKIGKLRTTQQFLTEN
>NZ_CP032527.2|WP_013059279.1|679815_680292_+|transcription-elongation-factor-GreA
MAQEKVFPMTEEGKLKLEQELEYLKTVKRKEVVERIKIARSFGDLSENSEYDSAKDEQAFVEGRITTLENMIRNAKIIEEDVENSSIVSLGKSVTFVELPDGDEETYTIVGSAEADPFEGKISNDSPIAKSLMGKQIGDQVTVQTPGGDMSVKIVSVK
>NZ_CP032527.2|WP_013059280.1|678961_679597_+|uridine-kinase
MGKKPVVIGIAGGSGSGKTTVTKAIYEYFKGHSIMLLEQDYYYKDQSDVPFEQRLQTNYDHPLAFDNDLLIEHLQNLLNYESIDKPVYDYAIHTRSEKVIREEPKDVIILEGILVLEDQRLRNLMDIKLYVDTDADLRIIRRMLRDIKERERTLESVVDQYVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL
>NZ_CP032527.2|WP_016765612.1|677691_678954_+|U32-family-peptidase
MAVQIDTVVEGKRVITKKPELLAPAGNLEKLKVAVHYGADAVFIGGKEFGLRSNADNFTFEEMAEGVQFANKYGARIYVTTNIFAHNENMDGLEDYLMGLERAGVSGIIVADPLIIETCRRVAPKLEVHLSTQQSLSNWKAVQFWKEEGLERVVLARETGAEEMREMKEKVDIEIEAFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDYDLFKVEDGKTETALFDEQDDPFAMSPKDLNLIQSIPQMIELGIDSLKIEGRMKSIHYIATVVSVYRKVIDAYCADPENFVIQQEWLDELDKCANRDTAPAFFEGVPGVDEQMFGLHGKKTKFDFAGLVLNYDEETSIVTLQQRNYFKPGEEVEFFGPEIKNFTQKIDKIWDEDGNELDAARHPLQIVKFKVDQPLFSYNMMRKGI
>NZ_CP032527.2|WP_016765613.1|676722_677652_+|U32-family-peptidase
MKKPELLVTPTAVSEIESLLQAGATAVMVGEQRYGLRLAGEFKREDIVEAVNIAHQHNAKVYVAMNGLFHNDKIAELNEYILFLKEASVDAIVFGDPAVLMAVRETAPEMKMHWSTETTGTNWYSCNYWGRKGAKRAVLARELSMDSIIDIKEKAEVEIEVQVHGMTCMFQSKRSLLGNYFEYQGKVMEIENRKVEKDMFLLDNERNNKYPIFEDENGTHIMSPNDMCIIDELSEMIDAEVDVFKIDGVLKSPQYILEVTKKYRQAIDLCVDDREEYENIKDDLLEEIESLQPINRPLDTGFFFKETVY
>NZ_CP032527.2|WP_013059283.1|676069_676726_+|O-methyltransferase
MLLQNVEQYVEKLIPKRQELIEEMEAYAKEHHVPIMELIGVETLLQILRLHQPKHILEIGTAIAYSSIRMTHALPEARVVTVERNEERYQKAQEFIERAGKQDKIVSLFGDALELRDEIERHGPYDAVFIDAAKGQYQRFFEHYEPMLSSKGMIISDNVLFKGHVATDLAEVETRRRRSLIKKIQAYNTWLMNHPDYYTTILPIGDGIAISIKRGDQE
>NZ_CP032527.2|WP_016765614.1|674784_675888_+|endolytic-transglycosylase-MltG
MSQQTFLPPNRSRKKRVIFITIIVLLLLVGGAFFYAQSRLTPVDRNSNKKVNVTIPQGSSVQSIGTVLQKEDLIKSKSAFRYYVKLTHVSGFQAGTYLFSPSMSLGEMVEKMEKGEVSKQPDIRVTIPEGRQLVEIADIIAKNTKFTKDEVMKKLDDKAFVNKMKEKYPDLVTDEVMQKDIKHPLEGYLYPVTYDFYDKNVSLDEILDKMVGKTNNVVGQYSGQMEKKKFSAHKLLTMSSLIEEEATAKVDREKIASVFYNRLEKNMPLQTDPTVLYALGEHKDRVFYKHLEVDSPYNTYKVKGLPPGPIASSGLMSIKAALHPANTDYLYFLATPEGKVIFTKTLEEHNKEKAKHITGKEKQNTEK
>NZ_CP032527.2|WP_013059285.1|674087_674372_+|DUF1292-domain-containing-protein
MSVEENKITIVDENGNEQLCEILFTFDSDQYNKSYVIYYPIGADQDDEEEIEIHASAFTPSEDGQDGELQPIETEEEWDMVEEMVNTFLDEEGE
>NZ_CP032527.2|WP_013059286.1|673516_673933_+|Holliday-junction-resolvase-RuvX
MRVLGLDVGTKTIGVAVSDEMGWTAQGIETIKIADEQMEQSYPRLQQLIDEYSVEKIVVGLPKNMNGTIGPRGEACIEFADNVKEKLNIETMMWDERLSTMAAERVLLSADVSRKKRKKVIDKMAAVMILQGYLDSKQ
>NZ_CP032527.2|WP_013085082.1|683653_683869_-|DUF2536-family-protein
MNFEFEMIEDKIEFFEAPDVKMLEKQIAEKIDQNKAILLEVHSVSHQMSVDYEQGKKLYSAVVHFKLKKQR
>NZ_CP032527.2|WP_016765609.1|684007_684649_+|class-I-SAM-dependent-methyltransferase
MGLEFLDIFEKWANEYDASVSGKDEQYREVFRNYNEILEYVADRSIGHVIEFGTGTGNLTKKLLEKELTVVGIEPSVPMRQLAHQKLGADVLVTPGDFLQFDTSLFPAESLVSTYAFHHLTDKEKEEAVINYGKLLQTGGKIVFADTMFETADSFADTIVQAKRKGYTQLAEDLEREYYTTIPVLKQIFESNGFHITFTQFNHFVWVLEATKQ
>NZ_CP032527.2|WP_016765608.1|684666_685362_+|5'-methylthioadenosine/S-adenosylhomocysteine-nucleosidase
MKVAIIGAMEEEVTILRDKIENRQETVIAGCEYSTGTISGVEVVLLKSGIGKVNAALSTAILLEKFKPDYVINTGSAGGFHPELNVGDAVISTEVRHHDVDVTVFNYEYGQVPNLPAAFKADEKLVHLAEESALEVTDMKIVKGLIATGDSFMNDPVRVEFVRSKFPDLYAAEMEAAAVAQVCYQFDVPFVILRALSDIAGKESNVSFEQFLEKAAVNSTKLVLNFITKLK
>NZ_CP032527.2|WP_016765607.1|685504_686428_+|cysteine-synthase-family-protein
MKVAKNVHELIGNTPVIEITQFDLPREIRIFAKLEYVNPGGSVKDRLGKELLKEALSSGRLKRGGTVIEPTAGNTGIGLALAALQHEINVILCVPEKFSIEKQQLMKALGATVVQTPTEAGMKGAINKAQELLREIPGSYCPQQFANPANPLTYYKTLGPEIYEQLDGKIDVFVAGAGTGGTFMGTAKFLKEKNPSLKAVIVEPEGSILNGGKSGPHLTEGIGMEFIPDYMDRSYFNAIHTVEDVYAFQRVKELALKEGLLVGSSSGAAFEAALLEAKNAEKGAHIVTIFPDSSERYLSKNIYSGGR
>NZ_CP032527.2|WP_016765606.1|686429_687563_+|bifunctional-cystathionine-gamma-lyase/homocysteine-desulfhydrase
MKRKTQLIHGGIVGDEQTGAVSVPIYQVSTYKQEGAGKHTGYEYSRTGNPTRHALEELIKEIEGGYAGFAFGSGMAATTAVFMLFNSGDHVLITDDVYGGTYRVITKVLSRIGIEATFIDTSDIENIKKEIRPNTKAIYIETPTNPLLKITDLQQASSVAKQHHLLTIVDNTFSTPYWQNPIEKGADIVLHSATKYLGGHSDVVAGLAVVNSPKLAEDLHFIQNATGGILGPQDSWLLMRGIKTLGIRMEEHEFNTGKIVEFLLAHPAVTKVYYPGLNTHPNHLIAKKQARGFGGMVSFDVGSEEKAEQVLSKVKYFTLAESLGAIESLISIPSKMTHASIPSDRRKELGITDGLIRISVGLEDVEDLIEDLEEALK
>NZ_CP032527.2|WP_013085078.1|687644_687875_+|hypothetical-protein
MKAQRIKAKIEDYSRFIYVLLAVSTFLYIGVMIGQGEKSDMQLGIMEAIVILFAALAFYFSYQTKKLKKELMKEKE
>NZ_CP032527.2|WP_013059269.1|688265_688406_+|YrzI-family-small-protein
MTLNIFFLTITIKSRQYSEAEIKHEQYVRQLEEEIKDRKYEFYRHF
>NZ_CP032527.2|WP_013059268.1|688576_689305_-|RNA-polymerase-sporulation-sigma-factor-SigK
MSALFTALGYFFKELVFLVSYVKNNAFPQPLSAAEEKRYLSLMEQGDQEARNLLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKAIESYSQGKGTKLATYAARCIENEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLIDVLKSESDDVIDMIQLNMELEKIKEYIDILDDREKEVIVGRFGLDLQDEKTQREIAKELNISRSYVSRIEKRALMKMFHEFYRAEKEKKKSGKKEN
>NZ_CP032527.2|WP_013059266.1|689846_690386_-|CDP-diacylglycerol--serine-O-phosphatidyltransferase
MFLLDYLDHTIKKLRSQAANSLTIVNLSLGSFAILFVMKNELNLSLLLIFLAALADRFDGMVARKLQIESELGKQLDSMCDIISFGIAPALLLYQSILSHFGAAGSIVTICYIACGALRLARFNITENTGYFTGLPITAAGCLLTLSYLGVPYLPSHFYMFLIIVLACLMISTFKLKKV
>NZ_CP032527.2|WP_013085076.1|690500_691283_+|phosphatidylserine-decarboxylase
MLQHLYRTFIELTNHQGSSKLIRKFTFSKWSRFVIPSYTKVFKVNKEEMDKPLHHYQTLHELFIRRLNPSARPVDQQKDSVVSPVDAKIEAYGVITPQKEMIVKNKPYSIQEMVSNDLILEKYIEGQFIILYLSPKDYHRIHSPLKAQVGNTWTVGQKSYPVNSLGIKYGKEPLVKNFRKLTELTFENGHMLMVKVGAMFINSIEAVSKKEVVEKGEEMAYFTFGSTVILLFEKNSITFDSNVHSGSYVKYGEPIAHLKK

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Crispr_ID: NZ_CP032527_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP032527_2

1244456-1244550

Orphan

Consensus_repeat	Method
CCACCTGGAGGAGGAGGCCAAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP032527_2

>merge|NZ_CP032527|2|1244456-1244550|CRISPRCasFinder
TTTCCACCTGGAGGAGGCCAAGGGTTTCCATCGTTTCCACCTGGAGGAGGAGGCCAAGGATTTCCACCGCCGCCACCTGGAGGAGGAGGTCAAGG

>NZ_CP032527|2|2|1244456-1244550|CRISPRCasFinder
TTTCCACCTGGAGGAGGCCAAGG	GTTTCCATCGTTTCCACCTGGAGGAGGAGGCCAAGGATTTCCACCGCCG
CCACCTGGAGGAGGAGGTCAAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP032527.2\|WP_016765302.1\|1245012_1245639_+\|FMN-dependent-NADH-azoreductase	unknown	unknown	gnl\|CDD\|224103
NZ_CP032527.2\|WP_013084668.1\|1246204_1246702_+\|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|376324
NZ_CP032527.2\|WP_013084671.1\|1243710_1244256_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016765304.1\|1240155_1241604_+\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NZ_CP032527.2\|WP_013058702.1\|1249337_1249610_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_026106676.1\|1235812_1236649_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP032527.2\|WP_016765306.1\|1236635_1237406_+\|sporulation-protein	unknown	unknown	gnl\|CDD\|369195
NZ_CP032527.2\|WP_016765309.1\|1234375_1235437_-\|DUF2515-family-protein	unknown	unknown	gnl\|CDD\|371209
NZ_CP032527.2\|WP_013058701.1\|1249631_1250450_+\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|179508
NZ_CP032527.2\|WP_016765301.1\|1246739_1247567_+\|PRD-domain-containing-protein	unknown	unknown	gnl\|CDD\|170086
NZ_CP032527.2\|WP_013084672.1\|1241855_1243022_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NZ_CP032527.2\|WP_013058713.1\|1238514_1238838_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016765300.1\|1247746_1249126_+\|PTS-sucrose-transporter-subunit-IIBC	unknown	unknown	gnl\|CDD\|131051
NZ_CP032527.2\|WP_016765297.1\|1252422_1253265_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP032527.2\|WP_013058711.1\|1239236_1239941_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_CP032527.2\|WP_016765298.1\|1251792_1252302_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP032527.2\|WP_074893265.1\|1235554_1235809_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_013084675.1\|1237641_1238268_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NZ_CP032527.2\|WP_034649394.1\|1250551_1251757_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_080621475.1\|1245770_1245983_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP032527.2\|WP_016765302.1\|1245012_1245639_+\|FMN-dependent-NADH-azoreductase	gnl\|CDD\|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	3.62998e-85
NZ_CP032527.2\|WP_016765301.1\|1246739_1247567_+\|PRD-domain-containing-protein	gnl\|CDD\|170086	PRK09772, PRK09772, transcriptional antiterminator BglG; Provisional.	5.01348e-49
NZ_CP032527.2\|WP_016765304.1\|1240155_1241604_+\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.13352e-136
NZ_CP032527.2\|WP_013058701.1\|1249631_1250450_+\|membrane-protein-insertase-YidC	gnl\|CDD\|179508	PRK02944, PRK02944, YidC family membrane integrase SpoIIIJ.	6.90293e-106
NZ_CP032527.2\|WP_026106676.1\|1235812_1236649_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.70165e-49
NZ_CP032527.2\|WP_016765306.1\|1236635_1237406_+\|sporulation-protein	gnl\|CDD\|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	1.36583e-92
NZ_CP032527.2\|WP_016765309.1\|1234375_1235437_-\|DUF2515-family-protein	gnl\|CDD\|371209	pfam10720, DUF2515, Protein of unknown function (DUF2515). This family is conserved in Firmicutes. Several members are annotated as YppC. The function is not known.	1.6086e-122
NZ_CP032527.2\|WP_013084672.1\|1241855_1243022_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	2.86899e-108
NZ_CP032527.2\|WP_016765300.1\|1247746_1249126_+\|PTS-sucrose-transporter-subunit-IIBC	gnl\|CDD\|131051	TIGR01996, Includes:_Phosphotransferase_enzyme_IIB_component, PTS system, sucrose-specific IIBC component. This model represents the fused enzyme II B and C components of the sucrose-specific PTS sugar transporter system. Sucrose is converted to sucrose-6-phosphate in the process of translocation into the cell. Some of these transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci, Streptococci, Lactococci, Lactobacilli, etc. which contain their own A domain as a C-terminal fusion. This family is closely related to the trehalose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively).	0
NZ_CP032527.2\|WP_016765297.1\|1252422_1253265_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.01039e-46
NZ_CP032527.2\|WP_013058711.1\|1239236_1239941_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	1.12353e-162
NZ_CP032527.2\|WP_016765298.1\|1251792_1252302_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.03492e-16
NZ_CP032527.2\|WP_013084675.1\|1237641_1238268_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.26341e-45
NZ_CP032527.2\|WP_013084668.1\|1246204_1246702_+\|PTS-glucose-transporter-subunit-IIA	gnl\|CDD\|376324	pfam00358, PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1.	2.28018e-69

>NZ_CP032527.2|WP_013084671.1|1243710_1244256_+|hypothetical-protein
MIIGASVTALLLLWWTIFYSGRYYHYVSEPVGKRISLHVGIHVTLVVGVNACLWLEQPLLFSSILAGCAGLGAGWFVGIPFSVKSILSGIMGGIGTGVSFYISMSMWMDQFNWLSFLLIGTSVIFSGSSLFQVLKSIPSFEKVLVKMWIQHPFLIAPILITVFWLYNFIEKYFPQADPTRK
>NZ_CP032527.2|WP_013084672.1|1241855_1243022_-|rod-shape-determining-protein-RodA
MGENQRNVSRFDWNLAFLIFLLFCVSVVAIHSAEKIGQYDKNFVAQQVVFYIIGMVIIGFVMRFDSDQLQKLTWVFYGFGNFLLLLLLVAPSSIAREINGAKSWFTLPGFSLQPSEFMKVFLIITLSTVIVKHNEKYRIRTVREDFLLLGKLGAVLALPLLLIMQQPDLGTALVFLAITVGLVFVSGVSWKIIAPAFLGITAVGSVILGLVVYAPSLLEKYLGVKQYQFGRIYSWLDPESYSSGEGYHLKKSLDAIGSGMVNGKGIGNGVVYLPEGQTDFIFAVIGEEFGFIGASIVISLFFVLVYYLIKLGLETKNEFNSYLCVGVISMLTFHVFQNIGMTIQVLPITGIPLPFISYGGSSLMGNMFAMGLMFGISWHHKRYMFGND
>NZ_CP032527.2|WP_016765304.1|1240155_1241604_+|SulP-family-inorganic-anion-transporter
MVASIKQQWFSNVRADILSGMTVALALIPEALAFSIIAGVDPMVGLYASFCMAIVIAFTGGRPAMISAATGAMSLLMINLVKDHGIEYLFAATVLTGIIQILLGVLKVGRFLSFLPQTVMIGFVNALGILIFTAQLPHFQGANWMMYAMVAGTLLIVYLFPLMTKAIPSPLVAIVLMTIVAIVFHLDLKTVGDMGNITRSLPVLHFPKVDLSVETLLIILPYSLPLAIVGLLESMLTATVLDEITDTPSNKNKEARGQGIANIVTGFFGGMAGCAMIGQSMINVKSGGRGRLSTLVAGVFLLFLIMMLGDVVKQIPMAALVGVMFMVAAGTFDWQSLKDLTKYPLSDAIVMVVTVVIVLFTHNLALGVMVGIVLSTIVFGWKMAKIKTTSQTEGNMKQYRVSGQLFFATISFFMDEFQYETDPDTIIIDFSSSHIWDQSAVIGISKIIDKYERLNKKVIVKGLNEDSKKIVRQIGITSLSNK
>NZ_CP032527.2|WP_013058711.1|1239236_1239941_+|purine-nucleoside-phosphorylase
MSVHIGAKQGDIAETILLPGDPLRAKYIAETFLEDVTCYNEVRGMLGFTGTYKGKRVSVQGTGMGVPSIAIYVNELMNEYGVQNLIRVGTCGAIQKDVKVRDVILAMSSSSDSQMNRVKFGPIDYAPTANFDLLKRAYDAGVEKGLQLKVGSVFTSDQFYNEDGQLEKLAAHGVLAVEMETTALYTLAAKYGRNALSVLTVSDHIFTGEETTSEERQTTFNDMIVVALEAAINE
>NZ_CP032527.2|WP_013058713.1|1238514_1238838_+|hypothetical-protein
MLSVWTTIKKQFNISTEYDVTIMQTEEKGEKRGYKPVHRLTITAFDHQDAATQVFQMFNIADNLPKDCDARFISTGDILLIDEGTRGKYYYKLWTDGWQKVNRLHVR
>NZ_CP032527.2|WP_013084675.1|1237641_1238268_+|phosphatase-PAP2-family-protein
MVNRTTKYSLFIVSLLAFFLLILFTFNTPWVKQLDFNVLHTIEGWRTDTLTPIIIFITTVGSWYVTAPIWFAIIVLLLYKRKGLLVLYITLVFWGVRALNWGLKEIFARPRPDWSQVVPASHYSFPSGHAMNSMAFYSGVLLLIWMYTRSRAVKTAAACVIAIVILLIGFSRLYLGVHFLTDILAGYCLGLAWSLGVYLLSKRLYNQK
>NZ_CP032527.2|WP_016765306.1|1236635_1237406_+|sporulation-protein
MALFNKALARIGIGAARVDAKLVNDEFRAGEKIEGIVEVYGGNVEQKIDSIYLRLFTTYVKERDDKKYKQDIELNTFKINDPFTIQPSETKSIPFTFQLPDDTPVTLGRTRVWVATSLDIKDAVDPSDIDHVKVLPNLMVTSTIEAMEQLGFRLRQVECEEAPRRMRKRLPFVQEFEFVPSGGVYAGKVDEIEIIVQPSGLHDYNLFIEVDRRARGFGGFLSEMLDADESLVHVHVSEKEIPQLKNILTSIISRYS
>NZ_CP032527.2|WP_026106676.1|1235812_1236649_+|serine/threonine-protein-kinase
MMKNRMFKYFYRWLVDRPFKKGKVICGRYEIIDVLGMGSYGITYVANDIVQQKKVVVKQLRKTKQRTSQGLKSYHYEAKLLSQLNHPQIPSLYEAIETDEGCFLVMELIQGKTFEGLIFEEKCVYTEEQALNILLNILDVVSAIHEQGIVHRDLRIPNIIDVNGTIYVIDFGLARFLGDHEETSTLIEEQQFMRQTSAASDIYALGHFLLFLLYSGYEPTEQQERSWEQELHLSAPIKTMIQKMLRADESYESIKSLQKDIYDYINSKNSGRGKYGAI
>NZ_CP032527.2|WP_074893265.1|1235554_1235809_+|hypothetical-protein
MFRKIFESLTGSKHRRYSSSDRHYRRARHYSSSDHHYRRPRHHSSSSDYKRSKYYDSHSHSKYGHHHYKRKRKSGSFFSSFFSS
>NZ_CP032527.2|WP_016765309.1|1234375_1235437_-|DUF2515-family-protein
MTSTNTNPLIRLEDVLRLQQMMQLKPPATLPLSFIGEDVKLIKEIRKKVKKANQNNVTRTQAYLDYYQKHPEIHWAFLAHLVSRNGGYYMTDLSTTLIKSLLSPEKQHAYFLFLEHSNSAIFHDAYAQLLLYEKSKEQNSNLFHLLPAFHISSFMKAVWNDFWQHRNKTLLSIALIVNEQYHIEKNVLFKKEFQRDVLHSWQFHTQNFLGMTQIVFPYYSGNNIDLCGTKVYHFESVLKRIEVGKTLYVLLFYSNLHDSIYTFSLKHPHTGSRSDYNSDIFTKNRTHSKKLYSPTLTMSWGDRVHLFLRKDEWFEDEITFSLLESIPASSVKKIPLQHHIKVQSAIKAANPFS
>NZ_CP032527.2|WP_016765302.1|1245012_1245639_+|FMN-dependent-NADH-azoreductase
MANVLYVKVNPQVDEASFSTRLAQVFLDEYKTANPTDTVTTLDLYKETVPFIDGDVLAAWGKAGAGEELSAVELEKVTRMGELVEQFLQADKVIFSAPMWNLSFPPLMKAYIDNILIAGKTFKYTENGPVGLASDKKVVLLEARGGVYSEGPAAELEFTQSYLRTVMSFIGVQDFHLVVAEGMAYTPAEADNILAKASEKAKEVASTF
>NZ_CP032527.2|WP_080621475.1|1245770_1245983_+|hypothetical-protein
MIGGQAEDSCGKSGIDETPQERMRRGGSATARGKRSLARKSTEVSKAVRLMYTSCSSLDWIHFFMSQSLF
>NZ_CP032527.2|WP_013084668.1|1246204_1246702_+|PTS-glucose-transporter-subunit-IIA
MFKKLFGNKTKSKETTVLAPLSGNILPISEVPDPVFAQKMMGDGFAIEPSEGQVVSPVAGEVVQLFHTKHAVGLKTEAGTEVLIHIGLETVAMEGEGFEAHVAQGDKVSVGTPLITFDLALIQEKAKSIITPIVITNSDASESFEILAQGTVQKGETACAKVTMK
>NZ_CP032527.2|WP_016765301.1|1246739_1247567_+|PRD-domain-containing-protein
MKILKVLNNNAVVFKEGGVEKIAMGPGIAFQKGKNDLINAAKVEKVFVMKEEQEKFQELLKNLPEEHIQVAEEIISYAEQQLSATLSHHVHIALSDHLSFAVERIARGISIQNKLLNEIKSLYQPEYAIGVWALKHIKKRLDITMPIDEAGYIALHIHTAKLNSPGMQQLMMNTTIINEMVTIIKKELNMEIDENSMSYQRLLTHLRFALNRLAQNEPFHEMDEEMLNVLKVKYKKSYQCAETIKQFVKDEYEINFPEAELGYITLHICRLEQRI
>NZ_CP032527.2|WP_016765300.1|1247746_1249126_+|PTS-sucrose-transporter-subunit-IIBC
MDVKEIAEKLVPLLGGKENIASAQHCATRLRLVIRDESKIDQKGLDEIEDVKGAFSNSGQFQIIFGTGLVNKIHAAFVKELGDDEAAAPADHQEEMKKKMNPFARFARMLSNIFVPIIPAIVASGLLMGLLGMMKAFHWVSEDSALFVLLDMFSGAAFIILPILIGFSAAKEFGSNPYLGAVIGGILTHPMLLNPWTLADAKPEYMDLFGLSIPLIGYQGTVVPILLAIYVMSKIEKGLRKIVPNSVDLLVTPFLTVIITGFVSLVFIGPFGRYIGDLISISLQSLYDVAGVFAGILFGGLYSTIVLTGLQHSFHAIEAGLLANPKIGVNFLLPIWACANVAQGGAGLAVYFKTKNAKTKKIAIPAAISSFLGITEPIIFGVNLRLRKPFIAAAIGGAAGGGYVVLMHVVANAYGLTGIPMMAIAAPLGMSNLIHYIIGMIISVGVAFGVTWFMKLKED
>NZ_CP032527.2|WP_013058702.1|1249337_1249610_+|hypothetical-protein
MEFYHDLFLYAPYLSAFVLYILCYYMLREARFTAFHAEPVTDHVNAGIDPSVLTIWKRRNVFIHVYRKTPVKEKNNDEEDPFLLKNTSYI
>NZ_CP032527.2|WP_013058701.1|1249631_1250450_+|membrane-protein-insertase-YidC
MKRNKKLLLLGLMGALLLALAGCSSTKTPVTATSGGFWDHYFVYPLSMALTKIAEWAGGSYGLSIIIATVIIRLVLLPLILKQQKSTMAMQALRPEMEKIQKKYAGKKDPETQQKQQKEMMQLYQTHKINPVGGCLPIFIQMPIIIAFYNAIARTHEIAQHSFLWVSLGKPDPYFILPVVAAITTFLQIRVSMTDEIQPPMKMMMNIMPIFILVAGISLPSALALYWVIGNLFGIGQGYYLKKRMSLLKEKDAANNTAQAKTKPSPKSKSKS
>NZ_CP032527.2|WP_034649394.1|1250551_1251757_+|hypothetical-protein
MVKKIALCLLFLMLFPMQINAANTVKVSFIRQGNLWVYDNGTERQLSYARHASMPQWSSHGDIVAYAENDSLMIAPLKGKPLLVEHDVTHYQWSPVAEELAYISNGILVYYNVKTHEKKRVAVGVDQFSWFPEGDRFLITSAAALAPTGWGPVKLYTVSKYAGLDVKKVEAFTTLPAENDSFFAYTTSSFKWSPNGQWISFIAIPTASMSADANKLCIITKEGKAFQVVGDMLNVPNWFKWSNEEQVLAFIDGEGRFATENKKFTLKEMPVFKEHVFTPKGFADWDFTWTEKDNIIISRVPEAGWSNDEKKRPLPFLYSMDVKTNKQSQFTFPQKGLGDYAPVYHKATNQTMWIRTNRKQANLLTRVKDTKNDKVLISGLDLPGNYYELYRWNEVFSVYNP
>NZ_CP032527.2|WP_016765298.1|1251792_1252302_+|GNAT-family-N-acetyltransferase
MNIRLLVKEDADMYFELRLRALKDHPESFILSYEEEYEKEIADIRNYFPSSQSEFVVGAFMEKQLVGIVGFQQQKPLKVQHKGDIWGMYVAPEARGKGLGKKLLKTAVEQAFSKTNVLQIYLAVAAKNEGAKALYKSLGFTSYAYEKRALQVDGEFIDEEHMVLSIKSL
>NZ_CP032527.2|WP_016765297.1|1252422_1253265_+|ATP-binding-cassette-domain-containing-protein
MEKLIELKNVAKVYKKHTVLENVHTTLYKGETVAIVGKNGAGKSTFLKLIGGLSKPTKGTVHLHKETGTPGFVVEQFPQELRFTLAGYLQHMGRIQGLSKKKRSSRIEELLETFEMVEFRHEEIISFSKGMKQKVNMMQALLSSSKLLLLDEPLSGLDARAQLEVERIFTKLKERGMTIVFTCHEERLIHAVADRVITIGSQRILKNERVQLIEHLTVIEANVILNKPLRLLKEKCTKIEQHGNYWIFYIDKKYVNEFLAELLAVQAEVVKLYHMEREEI

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Crispr_ID: NZ_CP032527_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP032527_4

2237346-2237430

Orphan

Consensus_repeat	Method
TAGTACGCTAAAAACGGCAAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP032527_4

>merge|NZ_CP032527|4|2237346-2237430|CRISPRCasFinder
TAGTACGTAAAAAACGGCAAAAGGCTCAGTATAGTACGCCAAAAATAGCAAAAGTGAAGAGTAGTACGCTAAAAACAGCAAAAGT

>NZ_CP032527|4|4|2237346-2237430|CRISPRCasFinder
TAGTACGTAAAAAACGGCAAAAG	GCTCAGTATAGTACGCCAAAAATAGCAAAAGTGAAGAG
TAGTACGCTAAAAACAGCAAAAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP032527.2\|WP_016764594.1\|2234615_2235212_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP032527.2\|WP_013057538.1\|2243977_2244637_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|177683
NZ_CP032527.2\|WP_013083665.1\|2241283_2242108_+\|kinase/pyrophosphorylase	unknown	unknown	gnl\|CDD\|377080
NZ_CP032527.2\|WP_016764593.1\|2236055_2237078_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_100229239.1\|2230959_2231226_+\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730
NZ_CP032527.2\|WP_016764585.1\|2247760_2248591_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_CP032527.2\|WP_016764595.1\|2234034_2234613_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319825
NZ_CP032527.2\|WP_016764591.1\|2239824_2240706_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP032527.2\|WP_016764589.1\|2245057_2245882_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NZ_CP032527.2\|WP_016764596.1\|2232889_2233906_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226728
NZ_CP032527.2\|WP_129542287.1\|2229215_2229794_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_129542286.1\|2227481_2228747_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764587.1\|2246249_2246804_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP032527.2\|WP_013057548.1\|2232397_2232817_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349995
NZ_CP032527.2\|WP_016764590.1\|2242228_2243731_+\|malate:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|377591
NZ_CP032527.2\|WP_013083667.1\|2238047_2239511_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_080621434.1\|2245920_2246103_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764586.1\|2247001_2247562_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764597.1\|2231498_2231990_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764599.1\|2230349_2230730_-\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730

Protein	Function_ID	Function_description	E-value
NZ_CP032527.2\|WP_016764594.1\|2234615_2235212_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	1.31751e-24
NZ_CP032527.2\|WP_013083665.1\|2241283_2242108_+\|kinase/pyrophosphorylase	gnl\|CDD\|377080	pfam03618, Kinase-PPPase, Kinase/pyrophosphorylase. This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity.	5.97841e-145
NZ_CP032527.2\|WP_013057538.1\|2243977_2244637_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|177683	PLN00052, PLN00052, prolyl 4-hydroxylase; Provisional.	1.55318e-40
NZ_CP032527.2\|WP_016764595.1\|2234034_2234613_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319825	cd07523, HAD_YsbA-like, uncharacterized family of the haloacid dehalogenase-like superfamily, similar to the uncharacterized Lactococcus lactis YsbA. The specific function of Lactococcus lactis YsbA is unknown. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.96469e-43
NZ_CP032527.2\|WP_100229239.1\|2230959_2231226_+\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	5.38037e-20
NZ_CP032527.2\|WP_016764585.1\|2247760_2248591_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	2.76267e-71
NZ_CP032527.2\|WP_016764591.1\|2239824_2240706_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.52616e-57
NZ_CP032527.2\|WP_016764596.1\|2232889_2233906_+\|hypothetical-protein	gnl\|CDD\|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	1.1715e-07
NZ_CP032527.2\|WP_013057548.1\|2232397_2232817_+\|hypothetical-protein	gnl\|CDD\|349995	cd18551, ABC_6TM_LmrA_like, Six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA and similar proteins. This group represents the six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA from Lactococcus lactis and similar proteins. This transmembrane (TM) subunit possesses the ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. Moreover, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis.	0.00168085
NZ_CP032527.2\|WP_016764590.1\|2242228_2243731_+\|malate:quinone-oxidoreductase	gnl\|CDD\|377591	pfam06039, Mqo, Malate:quinone oxidoreductase (Mqo). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.	0
NZ_CP032527.2\|WP_016764587.1\|2246249_2246804_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.70491e-12
NZ_CP032527.2\|WP_016764589.1\|2245057_2245882_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	4.86357e-38
NZ_CP032527.2\|WP_016764599.1\|2230349_2230730_-\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	2.19848e-15

>NZ_CP032527.2|WP_016764593.1|2236055_2237078_-|hypothetical-protein
MIKKEFAKIGKQIIRQLSSTVEKYKDIEDHMDLDAHGNPTIKTVAEHHRLSKSQISQLIFYHFLHVDERGIICDVSEKEIAAALNCTVRTVRNNNVVLAETELISYSRSGKGINICIVPYPQYFEEHGFGFMELEYTRFEELILIENVNALRLELRKELVYDNDTIKRQFNPAENTSKISFNDYKIFTPKYTHYKGMMQKIAETQTSAFKTVVQGSTIFFVLKDGAKNGKMSKQEKKDQYAAAIRRTIEETFVKLSGHSTDSTGIVMSSFQNEDIADLVQLSFEYGIERVKSALYSLIEQAFFSHDAQVVENYGGKIRTLIRKELSKNLQDQVPAELTAS
>NZ_CP032527.2|WP_016764594.1|2234615_2235212_-|mechanosensitive-ion-channel
MKDIQWVQKTLFNTGKWIDISEVIIKIILIFIIAQIVIRFARSVINKIFDFRFKTKLLRYNERKEITLKKLCLSIVMYVVYFIVLITSLEAIGINMKALLAGISVAGFITGLGAQNLIKDILNGFFILFEDQFSVGDHVSINDTKGTVEEIGLRTTKIRGVDGEFYFFANSNITKVANYTLGEIPEVHKPEQIKTREE
>NZ_CP032527.2|WP_016764595.1|2234034_2234613_+|HAD-IA-family-hydrolase
MNILWDFDGTIFDTYPTIVKAFKELLTDQTISEDDILKQMKISSDIAIKHFDIEKSLFDKHFHVLEQKINPKDKPAFPHVEDVLSFADTNVIVTHKSRQSTLDILAFFNMEHYFTEIITKDDGYKRKPDSGAYAYLHDKYQLDLVIGDRELDLKPARELGIKTCAFQNDDIEADYHLTSYDQFFTTVVNKNS
>NZ_CP032527.2|WP_016764596.1|2232889_2233906_+|hypothetical-protein
MITAIIVGAVILLALIIKGIGKPRGFRLYKEELPDELGIHEGNGFEDIVHSLEDSLPKAYVQQVKQRIQGRNTKDDEVEWTFFEMKRYFLLNAVIKDVPMFSAKVDEVWHEMIMFTVDYGRFTDRFFDRFLHHQPNVDTTPSPQPDKRAFFDWMYAHLFDITGNSRLLWGKFFQHPLDKSTLQDFQRLSEDELLDRYFLRNGKWEKLQRALIQTLKEEINAARKRKKAGGSTYFKKTAKKGNVSNELLLQGFVFYSLYKATNFSSHMNELLLYKKTMYAGDTASYSGYSCSSPWEDNRHHHQHDGGHHHHDSGSSCSSSNCSSSSCSSSSCGSGCSSS
>NZ_CP032527.2|WP_013057548.1|2232397_2232817_+|hypothetical-protein
MSLSAKKILLLVLVVICLVLVVMQFINRSAEPTSEQAQETLSKLPEQETVKEKAKGDEEAHKYRVYYITIEKIENGTYSGTTKEGTGIKFSDKNLNEPIPSNLKKGDIVKAYFDLEYSTKGLVKVEKVDEMPDDDESSS
>NZ_CP032527.2|WP_016764597.1|2231498_2231990_-|hypothetical-protein
MMFALIVVVGIVALGVASFYVIKRPQGAVDPEDRKPLVSVNGHVKFAEGINQISISKIDMYDQRLVINQVAIIPFNRIQRAEFSKVVKNEKGLHGAPVQRYFGELTIHFTDKNGQETYISCETPKKNQFHLIYQYDLMKRQLNKRLGLEDLQPYLTLQEPYEL
>NZ_CP032527.2|WP_100229239.1|2230959_2231226_+|DUF4183-domain-containing-protein
MFPKKVRIFEYYTVAGGSKRIFTDQDALKEYGTQHILDPESYSYSNLFINGVLQPSSNYSVQKGLLIINTEDIPLEKSPVILQMIKVI
>NZ_CP032527.2|WP_016764599.1|2230349_2230730_-|DUF4183-domain-containing-protein
MPLQIMKLAIAATTTVTASPTVSRFFYAATATTTGAATLTIDAADFFGDTGGAATALPALATDNIYYNVYINGVLQMAGLSTYTPGATGVGSLAITVPAGSSVLTGSPIVLEVVNFAPDSDTDVQT
>NZ_CP032527.2|WP_129542287.1|2229215_2229794_+|hypothetical-protein
MKTRVELTISLLIFLIILATTLGVVISLSGLLVASIQASEQDYIGAIVGSLGNIIGGIIGVLAAVLVAAYQIRKTFELERSKGAASNSAVLRLLKTELQSNCKLIQNFKSDYMEGNKAFLKSVSIDNWERCSLQIGMETSDTTLNAISSAYRKISLLKSESKINESTYDKLIDDLSTALSNIEEDLELLKTR
>NZ_CP032527.2|WP_129542286.1|2227481_2228747_+|hypothetical-protein
MEKTELIVPEGIKDSIFQYRFVDLLKKHGKPFSGKPTIWERLQQAIENDRAFEESFNQFIIDEISNGKSRQVYICNFSIESLAILGNYTSLQAKMAAKELPTENLNRLLEADVEDGEIVYFKVKTDEMISSKVTKISLSFFNEMPVEDESEGKTILRNFPNYVWIDILPDKKYLQIKVRPAYANHIMNLQESKRVFEYYWEFLKEKFGIVFTDMSETKNTLYNMFKELTEKAEAPYTKKVESIMPEVDKQVLKLAESINLLNYKDPVDIPNRLARLFERALILSDLKSYKGYNLGKIGIVDRIDFSDQSGARVNALSGNEGIEVADIYFDTRETLDELKRLNKIWIRWFVPTEKFKLFKDTNNTLAPSGPEIEQVETRIEVMNNRVGIYFLNDQSVPKEVQDHVLSLFREFEEGEIPKTIN
>NZ_CP032527.2|WP_013083667.1|2238047_2239511_-|hypothetical-protein
MNEPSNFSPYLIKQISDAIDDNIKAKCIDFLYDSHSFFSNEKDFIEDYILNILQDTFVLENKLINPKEIRNPAYKRRQSNKKNWLQTLKKDIKAEKPNPIFEDIELAKKVMDKKVDTEHLKKLFGVEKPEDILKIKLKEVEAWAKSKKTNITDFPYLDSKMNYQIEKAFHTDFTFLIAEIILEKYNGNLSNWIDKRLNSWVEAPIFSNESHSLKTNMEVKTNSQEVVLYNDYKVDEEYFIRTIIPVNDNQTVLSKRNMVLDPKDSQIIQFALSQRDEMFYKEKTVTLDLADIVKEIYNSKGVKNYEAVEARIMKIARYHVEGVAKKKNSRDTKFAINFFQKAVIETDEVTGRRYATIVFSDDTHQGFLNQQFVQIYSDVIKKFKDNSLSSLLLYAFQKERLDCYLQEKSYTHFYPYQYFASKVRFRSKKIDVNLKLINESLAEFVSNQVLIQSYQQKLQGFEISFIPLQNYEIQDYFGGEHRETLEG
>NZ_CP032527.2|WP_016764591.1|2239824_2240706_+|Cof-type-HAD-IIB-family-hydrolase
MLLKPKAIFLDMDGTILNRSNKVSIQTKEIIDELRKQGIFVFIATGRAFDEIEELVPEGFQVDGFITSNGMAGYVGKESVFQHSLSLQLVETIIEKARANKVYYELFPYGTPRVTLKQDQSYVENEIREPKPDSVEINEWLSRKQAIKEEIDWKDSVEGSEFSKFYFFARTHEHIDKWKEKLEELKKEIDFTTSTSSKHNVEVMVANVNKATGIQQMLKHFNLPEQDILAIGDSNNDLPMFQFASYAVAMKNAPDHIQEIVDDVTEFNCDENGVSHYLSKFLLQKSTRSNPVL
>NZ_CP032527.2|WP_013083665.1|2241283_2242108_+|kinase/pyrophosphorylase
MNKRKIVYIVSDSVGETAELMVKAVLTQFSGEDIEIQNTSYVEDEGNIDNIIAEARCNEAIIAYTIVIPPLKQYLDQKAQEEGIVAIDLMTPLMSAFSQTFNKEPNLQPRLTRKLDDNYFRRVEAVEFAVKYDDGQDFRGIKRADLVLIGVSRTSKTPLSMYLAHKSLKVANIPLVPEVTPPDELFTIPKNKCIGLVITPDKLNEIRKERLKNLGLASQANYANVDRILEELDYAEKIMKRIGCPIVNVSGKAVEETAEVILSMLKKDKMKGYV
>NZ_CP032527.2|WP_016764590.1|2242228_2243731_+|malate:quinone-oxidoreductase
MSNVYKKTDVILIGAGVMSATLGSLLKELAPEWEIKVFEKLADAGEESSNEWNNAGTGHAALCELNYTSEQADGSIDITKAVRINEQFQLSRQFWSYLVSSNLIHHPQEFIMPIPHMSFVQGEKNVSFLKKRFEALSNNPLFQGMEYSDRPEKLKEWMPLVMKGRTSTEAIAATKIDSGTDVNFGALTRMLFTHLKSKRVEINYNHSVENLTRTADGSWEVKVHDIHTGKQEYHTANFVFIGGGGGSLSLLQKTGIPESKHIGGFPVSGLFMVCNNPEVVAQHHGKVYGKAKVGAPPMSVPHLDTRYIDRKKTLLFGPFAGFSPKFLKTGSNLDLINSVKPNNILTMLAAGVKEMGLTKYLIQQVLLSDEKRMEELREFIPNAKSEDWDIVVAGQRVQVIKDTEAGGKGTLQFGTEVVSSADGSVAALLGASPGASTAVHVMLEVLEKCFPQHMKKWESKIKEMIPSYGLSLVENPALFNEIHASTSQTLDLSKKELVYR
>NZ_CP032527.2|WP_013057538.1|2243977_2244637_+|2OG-Fe(II)-oxygenase
MILTNTSLLTKEQTIFNHTGNKIKLEDREIDIVARFEEPLVLVLGNVLSNEECDELIQLSKDKMQRSKIGAAREVNSIRTSSGMFFEESENELVHQIERRLSKIMGPSIEYAEGLQVLKYLPDQEYKAHHDYFTSASKASKNNRISTLVMYLNDVEEGGETYFPKLGLSVSPTKGMAVYFEYFYSDAELNDRTLHGGAPVIKGEKWVATQWMRKQKIRS
>NZ_CP032527.2|WP_016764589.1|2245057_2245882_+|thermonuclease-family-protein
MKEIKAIICTMLAMFMLLLTGCSDEQASHSSTSSADTKQAVQVEDSSDQEEDHSPSKANREDVVGEAATVERVVDGDTLKVKMLNGKRDRVRLLLVDTPETKHPKLGVQPFGPEASAYTKKRLEGQEITLEFDVQERDQYGRLLAYVWIDNELYNEELLAKGLARVAVFPPNTKYVDEFKKIQEQARKSEKGIWSIENYAQEKGYNTDAVKNQASSKQKDTQSAESCEGKIKGNQNSKIYHVPTGAHYNQTMNHVIWFCTEKDAQEAGYKKAKN
>NZ_CP032527.2|WP_080621434.1|2245920_2246103_-|hypothetical-protein
MDDDYEKTPSAERYYGKCMGIFSRNSFTSASAAHMAPASSYTDWSLFVGWYLATPIQILT
>NZ_CP032527.2|WP_016764587.1|2246249_2246804_+|GNAT-family-N-acetyltransferase
MKIRKARKEDASAVTELLYDMLGSIARSHTAATTNEEALLRLKAFILSEKNRYSYHHITIAEVEEKVVGLMLCYEGSMLQTLYEPVKRFVRAKLNNPAWEIDIETEHGDYYIDSLCVDEAYRGKGIGTALLNVAKQEAKKRKMFLSLNVEYNNVEAKKLYQRIGFQEHKTIFIDKKPFFYMKTA
>NZ_CP032527.2|WP_016764586.1|2247001_2247562_+|hypothetical-protein
MNIRDLPFNMSYRFNEQLREVPVNPHQMKQGIIYLKKRALEEEDECAAAKTYGHIGVYERILGELTSSERHLLLAIYLYDRYADTIGEFLNTIRLGHTYHWQEQWDKANETFQLLIEQLKADEDLHIYEDFVYQHYGKCLLDQRVVSRAHHYFQRALEIRLKKGDKELIESTNSCIRLCLNKLKHS
>NZ_CP032527.2|WP_016764585.1|2247760_2248591_+|YitT-family-protein
MSKTVKDVIFLLIGSFVFSLAVNMFVIPIGLGEGGVTGISIILYYTTHLSTGITNFILNGILLIVGYKFLEKKTIVYTMITIIATSIFLHVTEGWGLHLHEELIGMVFAGVLLGVGIGMILRVGGTTAGSAIIARILNKFLNWKVSHALLIVDLLVVLASYFIIGIEKLLFTIVMLYITTKVIDFVIEGFDAKKAVTVISSNKNEVADQINEQLDRGVTILNGRGNYTKESKEILYVVINKQELIKLKKLIKKIDDEAFVIVHDVRDVIGKGFLSA

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Crispr_ID: NZ_CP032527_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP032527_5

2237503-2237587

Orphan

Consensus_repeat	Method
TAGTACGCTAAAAACGGCAAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP032527_5

>merge|NZ_CP032527|5|2237503-2237587|CRISPRCasFinder
CAGTACGTCAAAAATGGCAAAAGCTATTTTTAGTACGTGAAAAACGTCAAAAACGACGTGGTAGTACGACAAAAACAGCAAAAGT

>NZ_CP032527|5|5|2237503-2237587|CRISPRCasFinder
CAGTACGTCAAAAATGGCAAAAG	CTATTTTTAGTACGTGAAAAACGTCAAAAACGACGTGG
TAGTACGACAAAAACAGCAAAAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP032527.2\|WP_016764594.1\|2234615_2235212_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP032527.2\|WP_013057538.1\|2243977_2244637_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|177683
NZ_CP032527.2\|WP_013083665.1\|2241283_2242108_+\|kinase/pyrophosphorylase	unknown	unknown	gnl\|CDD\|377080
NZ_CP032527.2\|WP_016764593.1\|2236055_2237078_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_100229239.1\|2230959_2231226_+\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730
NZ_CP032527.2\|WP_016764585.1\|2247760_2248591_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_CP032527.2\|WP_016764595.1\|2234034_2234613_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319825
NZ_CP032527.2\|WP_016764591.1\|2239824_2240706_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP032527.2\|WP_016764589.1\|2245057_2245882_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NZ_CP032527.2\|WP_016764596.1\|2232889_2233906_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226728
NZ_CP032527.2\|WP_129542287.1\|2229215_2229794_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_129542286.1\|2227481_2228747_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764587.1\|2246249_2246804_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP032527.2\|WP_013057548.1\|2232397_2232817_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349995
NZ_CP032527.2\|WP_016764590.1\|2242228_2243731_+\|malate:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|377591
NZ_CP032527.2\|WP_013083667.1\|2238047_2239511_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_080621434.1\|2245920_2246103_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764586.1\|2247001_2247562_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764597.1\|2231498_2231990_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764599.1\|2230349_2230730_-\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730

Protein	Function_ID	Function_description	E-value
NZ_CP032527.2\|WP_016764594.1\|2234615_2235212_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	1.31751e-24
NZ_CP032527.2\|WP_013083665.1\|2241283_2242108_+\|kinase/pyrophosphorylase	gnl\|CDD\|377080	pfam03618, Kinase-PPPase, Kinase/pyrophosphorylase. This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity.	5.97841e-145
NZ_CP032527.2\|WP_013057538.1\|2243977_2244637_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|177683	PLN00052, PLN00052, prolyl 4-hydroxylase; Provisional.	1.55318e-40
NZ_CP032527.2\|WP_016764595.1\|2234034_2234613_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319825	cd07523, HAD_YsbA-like, uncharacterized family of the haloacid dehalogenase-like superfamily, similar to the uncharacterized Lactococcus lactis YsbA. The specific function of Lactococcus lactis YsbA is unknown. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.96469e-43
NZ_CP032527.2\|WP_100229239.1\|2230959_2231226_+\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	5.38037e-20
NZ_CP032527.2\|WP_016764585.1\|2247760_2248591_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	2.76267e-71
NZ_CP032527.2\|WP_016764591.1\|2239824_2240706_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.52616e-57
NZ_CP032527.2\|WP_016764596.1\|2232889_2233906_+\|hypothetical-protein	gnl\|CDD\|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	1.1715e-07
NZ_CP032527.2\|WP_013057548.1\|2232397_2232817_+\|hypothetical-protein	gnl\|CDD\|349995	cd18551, ABC_6TM_LmrA_like, Six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA and similar proteins. This group represents the six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA from Lactococcus lactis and similar proteins. This transmembrane (TM) subunit possesses the ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. Moreover, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis.	0.00168085
NZ_CP032527.2\|WP_016764590.1\|2242228_2243731_+\|malate:quinone-oxidoreductase	gnl\|CDD\|377591	pfam06039, Mqo, Malate:quinone oxidoreductase (Mqo). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.	0
NZ_CP032527.2\|WP_016764587.1\|2246249_2246804_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.70491e-12
NZ_CP032527.2\|WP_016764589.1\|2245057_2245882_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	4.86357e-38
NZ_CP032527.2\|WP_016764599.1\|2230349_2230730_-\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	2.19848e-15

>NZ_CP032527.2|WP_016764593.1|2236055_2237078_-|hypothetical-protein
MIKKEFAKIGKQIIRQLSSTVEKYKDIEDHMDLDAHGNPTIKTVAEHHRLSKSQISQLIFYHFLHVDERGIICDVSEKEIAAALNCTVRTVRNNNVVLAETELISYSRSGKGINICIVPYPQYFEEHGFGFMELEYTRFEELILIENVNALRLELRKELVYDNDTIKRQFNPAENTSKISFNDYKIFTPKYTHYKGMMQKIAETQTSAFKTVVQGSTIFFVLKDGAKNGKMSKQEKKDQYAAAIRRTIEETFVKLSGHSTDSTGIVMSSFQNEDIADLVQLSFEYGIERVKSALYSLIEQAFFSHDAQVVENYGGKIRTLIRKELSKNLQDQVPAELTAS
>NZ_CP032527.2|WP_016764594.1|2234615_2235212_-|mechanosensitive-ion-channel
MKDIQWVQKTLFNTGKWIDISEVIIKIILIFIIAQIVIRFARSVINKIFDFRFKTKLLRYNERKEITLKKLCLSIVMYVVYFIVLITSLEAIGINMKALLAGISVAGFITGLGAQNLIKDILNGFFILFEDQFSVGDHVSINDTKGTVEEIGLRTTKIRGVDGEFYFFANSNITKVANYTLGEIPEVHKPEQIKTREE
>NZ_CP032527.2|WP_016764595.1|2234034_2234613_+|HAD-IA-family-hydrolase
MNILWDFDGTIFDTYPTIVKAFKELLTDQTISEDDILKQMKISSDIAIKHFDIEKSLFDKHFHVLEQKINPKDKPAFPHVEDVLSFADTNVIVTHKSRQSTLDILAFFNMEHYFTEIITKDDGYKRKPDSGAYAYLHDKYQLDLVIGDRELDLKPARELGIKTCAFQNDDIEADYHLTSYDQFFTTVVNKNS
>NZ_CP032527.2|WP_016764596.1|2232889_2233906_+|hypothetical-protein
MITAIIVGAVILLALIIKGIGKPRGFRLYKEELPDELGIHEGNGFEDIVHSLEDSLPKAYVQQVKQRIQGRNTKDDEVEWTFFEMKRYFLLNAVIKDVPMFSAKVDEVWHEMIMFTVDYGRFTDRFFDRFLHHQPNVDTTPSPQPDKRAFFDWMYAHLFDITGNSRLLWGKFFQHPLDKSTLQDFQRLSEDELLDRYFLRNGKWEKLQRALIQTLKEEINAARKRKKAGGSTYFKKTAKKGNVSNELLLQGFVFYSLYKATNFSSHMNELLLYKKTMYAGDTASYSGYSCSSPWEDNRHHHQHDGGHHHHDSGSSCSSSNCSSSSCSSSSCGSGCSSS
>NZ_CP032527.2|WP_013057548.1|2232397_2232817_+|hypothetical-protein
MSLSAKKILLLVLVVICLVLVVMQFINRSAEPTSEQAQETLSKLPEQETVKEKAKGDEEAHKYRVYYITIEKIENGTYSGTTKEGTGIKFSDKNLNEPIPSNLKKGDIVKAYFDLEYSTKGLVKVEKVDEMPDDDESSS
>NZ_CP032527.2|WP_016764597.1|2231498_2231990_-|hypothetical-protein
MMFALIVVVGIVALGVASFYVIKRPQGAVDPEDRKPLVSVNGHVKFAEGINQISISKIDMYDQRLVINQVAIIPFNRIQRAEFSKVVKNEKGLHGAPVQRYFGELTIHFTDKNGQETYISCETPKKNQFHLIYQYDLMKRQLNKRLGLEDLQPYLTLQEPYEL
>NZ_CP032527.2|WP_100229239.1|2230959_2231226_+|DUF4183-domain-containing-protein
MFPKKVRIFEYYTVAGGSKRIFTDQDALKEYGTQHILDPESYSYSNLFINGVLQPSSNYSVQKGLLIINTEDIPLEKSPVILQMIKVI
>NZ_CP032527.2|WP_016764599.1|2230349_2230730_-|DUF4183-domain-containing-protein
MPLQIMKLAIAATTTVTASPTVSRFFYAATATTTGAATLTIDAADFFGDTGGAATALPALATDNIYYNVYINGVLQMAGLSTYTPGATGVGSLAITVPAGSSVLTGSPIVLEVVNFAPDSDTDVQT
>NZ_CP032527.2|WP_129542287.1|2229215_2229794_+|hypothetical-protein
MKTRVELTISLLIFLIILATTLGVVISLSGLLVASIQASEQDYIGAIVGSLGNIIGGIIGVLAAVLVAAYQIRKTFELERSKGAASNSAVLRLLKTELQSNCKLIQNFKSDYMEGNKAFLKSVSIDNWERCSLQIGMETSDTTLNAISSAYRKISLLKSESKINESTYDKLIDDLSTALSNIEEDLELLKTR
>NZ_CP032527.2|WP_129542286.1|2227481_2228747_+|hypothetical-protein
MEKTELIVPEGIKDSIFQYRFVDLLKKHGKPFSGKPTIWERLQQAIENDRAFEESFNQFIIDEISNGKSRQVYICNFSIESLAILGNYTSLQAKMAAKELPTENLNRLLEADVEDGEIVYFKVKTDEMISSKVTKISLSFFNEMPVEDESEGKTILRNFPNYVWIDILPDKKYLQIKVRPAYANHIMNLQESKRVFEYYWEFLKEKFGIVFTDMSETKNTLYNMFKELTEKAEAPYTKKVESIMPEVDKQVLKLAESINLLNYKDPVDIPNRLARLFERALILSDLKSYKGYNLGKIGIVDRIDFSDQSGARVNALSGNEGIEVADIYFDTRETLDELKRLNKIWIRWFVPTEKFKLFKDTNNTLAPSGPEIEQVETRIEVMNNRVGIYFLNDQSVPKEVQDHVLSLFREFEEGEIPKTIN
>NZ_CP032527.2|WP_013083667.1|2238047_2239511_-|hypothetical-protein
MNEPSNFSPYLIKQISDAIDDNIKAKCIDFLYDSHSFFSNEKDFIEDYILNILQDTFVLENKLINPKEIRNPAYKRRQSNKKNWLQTLKKDIKAEKPNPIFEDIELAKKVMDKKVDTEHLKKLFGVEKPEDILKIKLKEVEAWAKSKKTNITDFPYLDSKMNYQIEKAFHTDFTFLIAEIILEKYNGNLSNWIDKRLNSWVEAPIFSNESHSLKTNMEVKTNSQEVVLYNDYKVDEEYFIRTIIPVNDNQTVLSKRNMVLDPKDSQIIQFALSQRDEMFYKEKTVTLDLADIVKEIYNSKGVKNYEAVEARIMKIARYHVEGVAKKKNSRDTKFAINFFQKAVIETDEVTGRRYATIVFSDDTHQGFLNQQFVQIYSDVIKKFKDNSLSSLLLYAFQKERLDCYLQEKSYTHFYPYQYFASKVRFRSKKIDVNLKLINESLAEFVSNQVLIQSYQQKLQGFEISFIPLQNYEIQDYFGGEHRETLEG
>NZ_CP032527.2|WP_016764591.1|2239824_2240706_+|Cof-type-HAD-IIB-family-hydrolase
MLLKPKAIFLDMDGTILNRSNKVSIQTKEIIDELRKQGIFVFIATGRAFDEIEELVPEGFQVDGFITSNGMAGYVGKESVFQHSLSLQLVETIIEKARANKVYYELFPYGTPRVTLKQDQSYVENEIREPKPDSVEINEWLSRKQAIKEEIDWKDSVEGSEFSKFYFFARTHEHIDKWKEKLEELKKEIDFTTSTSSKHNVEVMVANVNKATGIQQMLKHFNLPEQDILAIGDSNNDLPMFQFASYAVAMKNAPDHIQEIVDDVTEFNCDENGVSHYLSKFLLQKSTRSNPVL
>NZ_CP032527.2|WP_013083665.1|2241283_2242108_+|kinase/pyrophosphorylase
MNKRKIVYIVSDSVGETAELMVKAVLTQFSGEDIEIQNTSYVEDEGNIDNIIAEARCNEAIIAYTIVIPPLKQYLDQKAQEEGIVAIDLMTPLMSAFSQTFNKEPNLQPRLTRKLDDNYFRRVEAVEFAVKYDDGQDFRGIKRADLVLIGVSRTSKTPLSMYLAHKSLKVANIPLVPEVTPPDELFTIPKNKCIGLVITPDKLNEIRKERLKNLGLASQANYANVDRILEELDYAEKIMKRIGCPIVNVSGKAVEETAEVILSMLKKDKMKGYV
>NZ_CP032527.2|WP_016764590.1|2242228_2243731_+|malate:quinone-oxidoreductase
MSNVYKKTDVILIGAGVMSATLGSLLKELAPEWEIKVFEKLADAGEESSNEWNNAGTGHAALCELNYTSEQADGSIDITKAVRINEQFQLSRQFWSYLVSSNLIHHPQEFIMPIPHMSFVQGEKNVSFLKKRFEALSNNPLFQGMEYSDRPEKLKEWMPLVMKGRTSTEAIAATKIDSGTDVNFGALTRMLFTHLKSKRVEINYNHSVENLTRTADGSWEVKVHDIHTGKQEYHTANFVFIGGGGGSLSLLQKTGIPESKHIGGFPVSGLFMVCNNPEVVAQHHGKVYGKAKVGAPPMSVPHLDTRYIDRKKTLLFGPFAGFSPKFLKTGSNLDLINSVKPNNILTMLAAGVKEMGLTKYLIQQVLLSDEKRMEELREFIPNAKSEDWDIVVAGQRVQVIKDTEAGGKGTLQFGTEVVSSADGSVAALLGASPGASTAVHVMLEVLEKCFPQHMKKWESKIKEMIPSYGLSLVENPALFNEIHASTSQTLDLSKKELVYR
>NZ_CP032527.2|WP_013057538.1|2243977_2244637_+|2OG-Fe(II)-oxygenase
MILTNTSLLTKEQTIFNHTGNKIKLEDREIDIVARFEEPLVLVLGNVLSNEECDELIQLSKDKMQRSKIGAAREVNSIRTSSGMFFEESENELVHQIERRLSKIMGPSIEYAEGLQVLKYLPDQEYKAHHDYFTSASKASKNNRISTLVMYLNDVEEGGETYFPKLGLSVSPTKGMAVYFEYFYSDAELNDRTLHGGAPVIKGEKWVATQWMRKQKIRS
>NZ_CP032527.2|WP_016764589.1|2245057_2245882_+|thermonuclease-family-protein
MKEIKAIICTMLAMFMLLLTGCSDEQASHSSTSSADTKQAVQVEDSSDQEEDHSPSKANREDVVGEAATVERVVDGDTLKVKMLNGKRDRVRLLLVDTPETKHPKLGVQPFGPEASAYTKKRLEGQEITLEFDVQERDQYGRLLAYVWIDNELYNEELLAKGLARVAVFPPNTKYVDEFKKIQEQARKSEKGIWSIENYAQEKGYNTDAVKNQASSKQKDTQSAESCEGKIKGNQNSKIYHVPTGAHYNQTMNHVIWFCTEKDAQEAGYKKAKN
>NZ_CP032527.2|WP_080621434.1|2245920_2246103_-|hypothetical-protein
MDDDYEKTPSAERYYGKCMGIFSRNSFTSASAAHMAPASSYTDWSLFVGWYLATPIQILT
>NZ_CP032527.2|WP_016764587.1|2246249_2246804_+|GNAT-family-N-acetyltransferase
MKIRKARKEDASAVTELLYDMLGSIARSHTAATTNEEALLRLKAFILSEKNRYSYHHITIAEVEEKVVGLMLCYEGSMLQTLYEPVKRFVRAKLNNPAWEIDIETEHGDYYIDSLCVDEAYRGKGIGTALLNVAKQEAKKRKMFLSLNVEYNNVEAKKLYQRIGFQEHKTIFIDKKPFFYMKTA
>NZ_CP032527.2|WP_016764586.1|2247001_2247562_+|hypothetical-protein
MNIRDLPFNMSYRFNEQLREVPVNPHQMKQGIIYLKKRALEEEDECAAAKTYGHIGVYERILGELTSSERHLLLAIYLYDRYADTIGEFLNTIRLGHTYHWQEQWDKANETFQLLIEQLKADEDLHIYEDFVYQHYGKCLLDQRVVSRAHHYFQRALEIRLKKGDKELIESTNSCIRLCLNKLKHS
>NZ_CP032527.2|WP_016764585.1|2247760_2248591_+|YitT-family-protein
MSKTVKDVIFLLIGSFVFSLAVNMFVIPIGLGEGGVTGISIILYYTTHLSTGITNFILNGILLIVGYKFLEKKTIVYTMITIIATSIFLHVTEGWGLHLHEELIGMVFAGVLLGVGIGMILRVGGTTAGSAIIARILNKFLNWKVSHALLIVDLLVVLASYFIIGIEKLLFTIVMLYITTKVIDFVIEGFDAKKAVTVISSNKNEVADQINEQLDRGVTILNGRGNYTKESKEILYVVINKQELIKLKKLIKKIDDEAFVIVHDVRDVIGKGFLSA

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Crispr_ID: NZ_CP032527_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP032527_3

2237188-2237280

Orphan

Consensus_repeat	Method
TAGTACGCTAAAAACGGCAAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP032527_3

>merge|NZ_CP032527|3|2237188-2237280|CRISPRCasFinder
TAGTACGCTAAAAACGGCAAAAGGTTCAAAGAATGCTGTCATATCAAGGGGTGCAGCGTATAGGTTTTTTAGTACGCCAAAAACGGCAAAAGC

>NZ_CP032527|3|3|2237188-2237280|CRISPRCasFinder
TAGTACGCTAAAAACGGCAAAAG	GTTCAAAGAATGCTGTCATATCAAGGGGTGCAGCGTATAGGTTTTT
TAGTACGCCAAAAACGGCAAAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP032527.2\|WP_016764594.1\|2234615_2235212_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP032527.2\|WP_013057538.1\|2243977_2244637_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|177683
NZ_CP032527.2\|WP_013083665.1\|2241283_2242108_+\|kinase/pyrophosphorylase	unknown	unknown	gnl\|CDD\|377080
NZ_CP032527.2\|WP_016764593.1\|2236055_2237078_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_100229239.1\|2230959_2231226_+\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730
NZ_CP032527.2\|WP_016764585.1\|2247760_2248591_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_CP032527.2\|WP_016764595.1\|2234034_2234613_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319825
NZ_CP032527.2\|WP_016764591.1\|2239824_2240706_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP032527.2\|WP_016764589.1\|2245057_2245882_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NZ_CP032527.2\|WP_016764596.1\|2232889_2233906_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226728
NZ_CP032527.2\|WP_129542287.1\|2229215_2229794_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_129542286.1\|2227481_2228747_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764587.1\|2246249_2246804_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP032527.2\|WP_013057548.1\|2232397_2232817_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349995
NZ_CP032527.2\|WP_016764590.1\|2242228_2243731_+\|malate:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|377591
NZ_CP032527.2\|WP_013083667.1\|2238047_2239511_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_080621434.1\|2245920_2246103_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764586.1\|2247001_2247562_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764597.1\|2231498_2231990_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764599.1\|2230349_2230730_-\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730

Protein	Function_ID	Function_description	E-value
NZ_CP032527.2\|WP_016764594.1\|2234615_2235212_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	1.31751e-24
NZ_CP032527.2\|WP_013083665.1\|2241283_2242108_+\|kinase/pyrophosphorylase	gnl\|CDD\|377080	pfam03618, Kinase-PPPase, Kinase/pyrophosphorylase. This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity.	5.97841e-145
NZ_CP032527.2\|WP_013057538.1\|2243977_2244637_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|177683	PLN00052, PLN00052, prolyl 4-hydroxylase; Provisional.	1.55318e-40
NZ_CP032527.2\|WP_016764595.1\|2234034_2234613_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319825	cd07523, HAD_YsbA-like, uncharacterized family of the haloacid dehalogenase-like superfamily, similar to the uncharacterized Lactococcus lactis YsbA. The specific function of Lactococcus lactis YsbA is unknown. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.96469e-43
NZ_CP032527.2\|WP_100229239.1\|2230959_2231226_+\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	5.38037e-20
NZ_CP032527.2\|WP_016764585.1\|2247760_2248591_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	2.76267e-71
NZ_CP032527.2\|WP_016764591.1\|2239824_2240706_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.52616e-57
NZ_CP032527.2\|WP_016764596.1\|2232889_2233906_+\|hypothetical-protein	gnl\|CDD\|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	1.1715e-07
NZ_CP032527.2\|WP_013057548.1\|2232397_2232817_+\|hypothetical-protein	gnl\|CDD\|349995	cd18551, ABC_6TM_LmrA_like, Six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA and similar proteins. This group represents the six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA from Lactococcus lactis and similar proteins. This transmembrane (TM) subunit possesses the ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. Moreover, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis.	0.00168085
NZ_CP032527.2\|WP_016764590.1\|2242228_2243731_+\|malate:quinone-oxidoreductase	gnl\|CDD\|377591	pfam06039, Mqo, Malate:quinone oxidoreductase (Mqo). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.	0
NZ_CP032527.2\|WP_016764587.1\|2246249_2246804_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.70491e-12
NZ_CP032527.2\|WP_016764589.1\|2245057_2245882_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	4.86357e-38
NZ_CP032527.2\|WP_016764599.1\|2230349_2230730_-\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	2.19848e-15

>NZ_CP032527.2|WP_016764593.1|2236055_2237078_-|hypothetical-protein
MIKKEFAKIGKQIIRQLSSTVEKYKDIEDHMDLDAHGNPTIKTVAEHHRLSKSQISQLIFYHFLHVDERGIICDVSEKEIAAALNCTVRTVRNNNVVLAETELISYSRSGKGINICIVPYPQYFEEHGFGFMELEYTRFEELILIENVNALRLELRKELVYDNDTIKRQFNPAENTSKISFNDYKIFTPKYTHYKGMMQKIAETQTSAFKTVVQGSTIFFVLKDGAKNGKMSKQEKKDQYAAAIRRTIEETFVKLSGHSTDSTGIVMSSFQNEDIADLVQLSFEYGIERVKSALYSLIEQAFFSHDAQVVENYGGKIRTLIRKELSKNLQDQVPAELTAS
>NZ_CP032527.2|WP_016764594.1|2234615_2235212_-|mechanosensitive-ion-channel
MKDIQWVQKTLFNTGKWIDISEVIIKIILIFIIAQIVIRFARSVINKIFDFRFKTKLLRYNERKEITLKKLCLSIVMYVVYFIVLITSLEAIGINMKALLAGISVAGFITGLGAQNLIKDILNGFFILFEDQFSVGDHVSINDTKGTVEEIGLRTTKIRGVDGEFYFFANSNITKVANYTLGEIPEVHKPEQIKTREE
>NZ_CP032527.2|WP_016764595.1|2234034_2234613_+|HAD-IA-family-hydrolase
MNILWDFDGTIFDTYPTIVKAFKELLTDQTISEDDILKQMKISSDIAIKHFDIEKSLFDKHFHVLEQKINPKDKPAFPHVEDVLSFADTNVIVTHKSRQSTLDILAFFNMEHYFTEIITKDDGYKRKPDSGAYAYLHDKYQLDLVIGDRELDLKPARELGIKTCAFQNDDIEADYHLTSYDQFFTTVVNKNS
>NZ_CP032527.2|WP_016764596.1|2232889_2233906_+|hypothetical-protein
MITAIIVGAVILLALIIKGIGKPRGFRLYKEELPDELGIHEGNGFEDIVHSLEDSLPKAYVQQVKQRIQGRNTKDDEVEWTFFEMKRYFLLNAVIKDVPMFSAKVDEVWHEMIMFTVDYGRFTDRFFDRFLHHQPNVDTTPSPQPDKRAFFDWMYAHLFDITGNSRLLWGKFFQHPLDKSTLQDFQRLSEDELLDRYFLRNGKWEKLQRALIQTLKEEINAARKRKKAGGSTYFKKTAKKGNVSNELLLQGFVFYSLYKATNFSSHMNELLLYKKTMYAGDTASYSGYSCSSPWEDNRHHHQHDGGHHHHDSGSSCSSSNCSSSSCSSSSCGSGCSSS
>NZ_CP032527.2|WP_013057548.1|2232397_2232817_+|hypothetical-protein
MSLSAKKILLLVLVVICLVLVVMQFINRSAEPTSEQAQETLSKLPEQETVKEKAKGDEEAHKYRVYYITIEKIENGTYSGTTKEGTGIKFSDKNLNEPIPSNLKKGDIVKAYFDLEYSTKGLVKVEKVDEMPDDDESSS
>NZ_CP032527.2|WP_016764597.1|2231498_2231990_-|hypothetical-protein
MMFALIVVVGIVALGVASFYVIKRPQGAVDPEDRKPLVSVNGHVKFAEGINQISISKIDMYDQRLVINQVAIIPFNRIQRAEFSKVVKNEKGLHGAPVQRYFGELTIHFTDKNGQETYISCETPKKNQFHLIYQYDLMKRQLNKRLGLEDLQPYLTLQEPYEL
>NZ_CP032527.2|WP_100229239.1|2230959_2231226_+|DUF4183-domain-containing-protein
MFPKKVRIFEYYTVAGGSKRIFTDQDALKEYGTQHILDPESYSYSNLFINGVLQPSSNYSVQKGLLIINTEDIPLEKSPVILQMIKVI
>NZ_CP032527.2|WP_016764599.1|2230349_2230730_-|DUF4183-domain-containing-protein
MPLQIMKLAIAATTTVTASPTVSRFFYAATATTTGAATLTIDAADFFGDTGGAATALPALATDNIYYNVYINGVLQMAGLSTYTPGATGVGSLAITVPAGSSVLTGSPIVLEVVNFAPDSDTDVQT
>NZ_CP032527.2|WP_129542287.1|2229215_2229794_+|hypothetical-protein
MKTRVELTISLLIFLIILATTLGVVISLSGLLVASIQASEQDYIGAIVGSLGNIIGGIIGVLAAVLVAAYQIRKTFELERSKGAASNSAVLRLLKTELQSNCKLIQNFKSDYMEGNKAFLKSVSIDNWERCSLQIGMETSDTTLNAISSAYRKISLLKSESKINESTYDKLIDDLSTALSNIEEDLELLKTR
>NZ_CP032527.2|WP_129542286.1|2227481_2228747_+|hypothetical-protein
MEKTELIVPEGIKDSIFQYRFVDLLKKHGKPFSGKPTIWERLQQAIENDRAFEESFNQFIIDEISNGKSRQVYICNFSIESLAILGNYTSLQAKMAAKELPTENLNRLLEADVEDGEIVYFKVKTDEMISSKVTKISLSFFNEMPVEDESEGKTILRNFPNYVWIDILPDKKYLQIKVRPAYANHIMNLQESKRVFEYYWEFLKEKFGIVFTDMSETKNTLYNMFKELTEKAEAPYTKKVESIMPEVDKQVLKLAESINLLNYKDPVDIPNRLARLFERALILSDLKSYKGYNLGKIGIVDRIDFSDQSGARVNALSGNEGIEVADIYFDTRETLDELKRLNKIWIRWFVPTEKFKLFKDTNNTLAPSGPEIEQVETRIEVMNNRVGIYFLNDQSVPKEVQDHVLSLFREFEEGEIPKTIN
>NZ_CP032527.2|WP_013083667.1|2238047_2239511_-|hypothetical-protein
MNEPSNFSPYLIKQISDAIDDNIKAKCIDFLYDSHSFFSNEKDFIEDYILNILQDTFVLENKLINPKEIRNPAYKRRQSNKKNWLQTLKKDIKAEKPNPIFEDIELAKKVMDKKVDTEHLKKLFGVEKPEDILKIKLKEVEAWAKSKKTNITDFPYLDSKMNYQIEKAFHTDFTFLIAEIILEKYNGNLSNWIDKRLNSWVEAPIFSNESHSLKTNMEVKTNSQEVVLYNDYKVDEEYFIRTIIPVNDNQTVLSKRNMVLDPKDSQIIQFALSQRDEMFYKEKTVTLDLADIVKEIYNSKGVKNYEAVEARIMKIARYHVEGVAKKKNSRDTKFAINFFQKAVIETDEVTGRRYATIVFSDDTHQGFLNQQFVQIYSDVIKKFKDNSLSSLLLYAFQKERLDCYLQEKSYTHFYPYQYFASKVRFRSKKIDVNLKLINESLAEFVSNQVLIQSYQQKLQGFEISFIPLQNYEIQDYFGGEHRETLEG
>NZ_CP032527.2|WP_016764591.1|2239824_2240706_+|Cof-type-HAD-IIB-family-hydrolase
MLLKPKAIFLDMDGTILNRSNKVSIQTKEIIDELRKQGIFVFIATGRAFDEIEELVPEGFQVDGFITSNGMAGYVGKESVFQHSLSLQLVETIIEKARANKVYYELFPYGTPRVTLKQDQSYVENEIREPKPDSVEINEWLSRKQAIKEEIDWKDSVEGSEFSKFYFFARTHEHIDKWKEKLEELKKEIDFTTSTSSKHNVEVMVANVNKATGIQQMLKHFNLPEQDILAIGDSNNDLPMFQFASYAVAMKNAPDHIQEIVDDVTEFNCDENGVSHYLSKFLLQKSTRSNPVL
>NZ_CP032527.2|WP_013083665.1|2241283_2242108_+|kinase/pyrophosphorylase
MNKRKIVYIVSDSVGETAELMVKAVLTQFSGEDIEIQNTSYVEDEGNIDNIIAEARCNEAIIAYTIVIPPLKQYLDQKAQEEGIVAIDLMTPLMSAFSQTFNKEPNLQPRLTRKLDDNYFRRVEAVEFAVKYDDGQDFRGIKRADLVLIGVSRTSKTPLSMYLAHKSLKVANIPLVPEVTPPDELFTIPKNKCIGLVITPDKLNEIRKERLKNLGLASQANYANVDRILEELDYAEKIMKRIGCPIVNVSGKAVEETAEVILSMLKKDKMKGYV
>NZ_CP032527.2|WP_016764590.1|2242228_2243731_+|malate:quinone-oxidoreductase
MSNVYKKTDVILIGAGVMSATLGSLLKELAPEWEIKVFEKLADAGEESSNEWNNAGTGHAALCELNYTSEQADGSIDITKAVRINEQFQLSRQFWSYLVSSNLIHHPQEFIMPIPHMSFVQGEKNVSFLKKRFEALSNNPLFQGMEYSDRPEKLKEWMPLVMKGRTSTEAIAATKIDSGTDVNFGALTRMLFTHLKSKRVEINYNHSVENLTRTADGSWEVKVHDIHTGKQEYHTANFVFIGGGGGSLSLLQKTGIPESKHIGGFPVSGLFMVCNNPEVVAQHHGKVYGKAKVGAPPMSVPHLDTRYIDRKKTLLFGPFAGFSPKFLKTGSNLDLINSVKPNNILTMLAAGVKEMGLTKYLIQQVLLSDEKRMEELREFIPNAKSEDWDIVVAGQRVQVIKDTEAGGKGTLQFGTEVVSSADGSVAALLGASPGASTAVHVMLEVLEKCFPQHMKKWESKIKEMIPSYGLSLVENPALFNEIHASTSQTLDLSKKELVYR
>NZ_CP032527.2|WP_013057538.1|2243977_2244637_+|2OG-Fe(II)-oxygenase
MILTNTSLLTKEQTIFNHTGNKIKLEDREIDIVARFEEPLVLVLGNVLSNEECDELIQLSKDKMQRSKIGAAREVNSIRTSSGMFFEESENELVHQIERRLSKIMGPSIEYAEGLQVLKYLPDQEYKAHHDYFTSASKASKNNRISTLVMYLNDVEEGGETYFPKLGLSVSPTKGMAVYFEYFYSDAELNDRTLHGGAPVIKGEKWVATQWMRKQKIRS
>NZ_CP032527.2|WP_016764589.1|2245057_2245882_+|thermonuclease-family-protein
MKEIKAIICTMLAMFMLLLTGCSDEQASHSSTSSADTKQAVQVEDSSDQEEDHSPSKANREDVVGEAATVERVVDGDTLKVKMLNGKRDRVRLLLVDTPETKHPKLGVQPFGPEASAYTKKRLEGQEITLEFDVQERDQYGRLLAYVWIDNELYNEELLAKGLARVAVFPPNTKYVDEFKKIQEQARKSEKGIWSIENYAQEKGYNTDAVKNQASSKQKDTQSAESCEGKIKGNQNSKIYHVPTGAHYNQTMNHVIWFCTEKDAQEAGYKKAKN
>NZ_CP032527.2|WP_080621434.1|2245920_2246103_-|hypothetical-protein
MDDDYEKTPSAERYYGKCMGIFSRNSFTSASAAHMAPASSYTDWSLFVGWYLATPIQILT
>NZ_CP032527.2|WP_016764587.1|2246249_2246804_+|GNAT-family-N-acetyltransferase
MKIRKARKEDASAVTELLYDMLGSIARSHTAATTNEEALLRLKAFILSEKNRYSYHHITIAEVEEKVVGLMLCYEGSMLQTLYEPVKRFVRAKLNNPAWEIDIETEHGDYYIDSLCVDEAYRGKGIGTALLNVAKQEAKKRKMFLSLNVEYNNVEAKKLYQRIGFQEHKTIFIDKKPFFYMKTA
>NZ_CP032527.2|WP_016764586.1|2247001_2247562_+|hypothetical-protein
MNIRDLPFNMSYRFNEQLREVPVNPHQMKQGIIYLKKRALEEEDECAAAKTYGHIGVYERILGELTSSERHLLLAIYLYDRYADTIGEFLNTIRLGHTYHWQEQWDKANETFQLLIEQLKADEDLHIYEDFVYQHYGKCLLDQRVVSRAHHYFQRALEIRLKKGDKELIESTNSCIRLCLNKLKHS
>NZ_CP032527.2|WP_016764585.1|2247760_2248591_+|YitT-family-protein
MSKTVKDVIFLLIGSFVFSLAVNMFVIPIGLGEGGVTGISIILYYTTHLSTGITNFILNGILLIVGYKFLEKKTIVYTMITIIATSIFLHVTEGWGLHLHEELIGMVFAGVLLGVGIGMILRVGGTTAGSAIIARILNKFLNWKVSHALLIVDLLVVLASYFIIGIEKLLFTIVMLYITTKVIDFVIEGFDAKKAVTVISSNKNEVADQINEQLDRGVTILNGRGNYTKESKEILYVVINKQELIKLKKLIKKIDDEAFVIVHDVRDVIGKGFLSA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP032527_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP032527_6

2237813-2238021

Orphan

Consensus_repeat	Method
TAGTACGCTAAAAACGGCAAAAG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP032527_6

>merge|NZ_CP032527|6|2237813-2238021|CRISPRCasFinder
TAGTACGTCAAAAATGGCAAAAGAATCAGAGTGGTACGTCAAAAACGGCAAAAGGTAGTAATTAGTACGCTAAAAACGGCAAAAGAAGCGAACAGGTACGTCAAAAACGGCAAAAGCTTCTGGTTAGTACGTTAAAAATGACAAAACTTCCAAACTATGAAATAAAAGTAGAGGGATATTTTGTATTTATAAGCTGAAAGTGGCAAAAT

>NZ_CP032527|6|6|2237813-2238021|CRISPRCasFinder
TAGTACGTCAAAAATGGCAAAAG	AATCAGAGTGGTACGTCAAAAACGGCAAAAGGTAGTAAT
TAGTACGCTAAAAACGGCAAAAG	AAGCGAACAGGTACGTCAAAAACGGCAAAAGCTTCTGGT
TAGTACGTTAAAAATGACAAAAC	TTCCAAACTATGAAATAAAAGTAGAGGGATATTTTGTAT
TTATAAGCTGAAAGTGGCAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP032527.2\|WP_016764594.1\|2234615_2235212_-\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|366370
NZ_CP032527.2\|WP_013057538.1\|2243977_2244637_+\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|177683
NZ_CP032527.2\|WP_013083665.1\|2241283_2242108_+\|kinase/pyrophosphorylase	unknown	unknown	gnl\|CDD\|377080
NZ_CP032527.2\|WP_016764593.1\|2236055_2237078_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_100229239.1\|2230959_2231226_+\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730
NZ_CP032527.2\|WP_016764585.1\|2247760_2248591_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_CP032527.2\|WP_016764595.1\|2234034_2234613_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319825
NZ_CP032527.2\|WP_016764591.1\|2239824_2240706_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP032527.2\|WP_016764589.1\|2245057_2245882_+\|thermonuclease-family-protein	unknown	unknown	gnl\|CDD\|214615
NZ_CP032527.2\|WP_016764596.1\|2232889_2233906_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226728
NZ_CP032527.2\|WP_129542287.1\|2229215_2229794_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_129542286.1\|2227481_2228747_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764587.1\|2246249_2246804_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP032527.2\|WP_013057548.1\|2232397_2232817_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349995
NZ_CP032527.2\|WP_016764590.1\|2242228_2243731_+\|malate:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|377591
NZ_CP032527.2\|WP_013083667.1\|2238047_2239511_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_080621434.1\|2245920_2246103_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764586.1\|2247001_2247562_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764597.1\|2231498_2231990_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016764599.1\|2230349_2230730_-\|DUF4183-domain-containing-protein	unknown	unknown	gnl\|CDD\|372730

Protein	Function_ID	Function_description	E-value
NZ_CP032527.2\|WP_016764594.1\|2234615_2235212_-\|mechanosensitive-ion-channel	gnl\|CDD\|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	1.31751e-24
NZ_CP032527.2\|WP_013083665.1\|2241283_2242108_+\|kinase/pyrophosphorylase	gnl\|CDD\|377080	pfam03618, Kinase-PPPase, Kinase/pyrophosphorylase. This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity.	5.97841e-145
NZ_CP032527.2\|WP_013057538.1\|2243977_2244637_+\|2OG-Fe(II)-oxygenase	gnl\|CDD\|177683	PLN00052, PLN00052, prolyl 4-hydroxylase; Provisional.	1.55318e-40
NZ_CP032527.2\|WP_016764595.1\|2234034_2234613_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319825	cd07523, HAD_YsbA-like, uncharacterized family of the haloacid dehalogenase-like superfamily, similar to the uncharacterized Lactococcus lactis YsbA. The specific function of Lactococcus lactis YsbA is unknown. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.96469e-43
NZ_CP032527.2\|WP_100229239.1\|2230959_2231226_+\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	5.38037e-20
NZ_CP032527.2\|WP_016764585.1\|2247760_2248591_+\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	2.76267e-71
NZ_CP032527.2\|WP_016764591.1\|2239824_2240706_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.52616e-57
NZ_CP032527.2\|WP_016764596.1\|2232889_2233906_+\|hypothetical-protein	gnl\|CDD\|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	1.1715e-07
NZ_CP032527.2\|WP_013057548.1\|2232397_2232817_+\|hypothetical-protein	gnl\|CDD\|349995	cd18551, ABC_6TM_LmrA_like, Six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA and similar proteins. This group represents the six-transmembrane helical domain of the multidrug resistance ABC transporter LmrA from Lactococcus lactis and similar proteins. This transmembrane (TM) subunit possesses the ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. Moreover, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis.	0.00168085
NZ_CP032527.2\|WP_016764590.1\|2242228_2243731_+\|malate:quinone-oxidoreductase	gnl\|CDD\|377591	pfam06039, Mqo, Malate:quinone oxidoreductase (Mqo). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidizes L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators.	0
NZ_CP032527.2\|WP_016764587.1\|2246249_2246804_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.70491e-12
NZ_CP032527.2\|WP_016764589.1\|2245057_2245882_+\|thermonuclease-family-protein	gnl\|CDD\|214615	smart00318, SNc, Staphylococcal nuclease homologues.	4.86357e-38
NZ_CP032527.2\|WP_016764599.1\|2230349_2230730_-\|DUF4183-domain-containing-protein	gnl\|CDD\|372730	pfam13799, DUF4183, Domain of unknown function (DUF4183). This domain of unknown function contains a highly conserved ING motif.	2.19848e-15

>NZ_CP032527.2|WP_016764593.1|2236055_2237078_-|hypothetical-protein
MIKKEFAKIGKQIIRQLSSTVEKYKDIEDHMDLDAHGNPTIKTVAEHHRLSKSQISQLIFYHFLHVDERGIICDVSEKEIAAALNCTVRTVRNNNVVLAETELISYSRSGKGINICIVPYPQYFEEHGFGFMELEYTRFEELILIENVNALRLELRKELVYDNDTIKRQFNPAENTSKISFNDYKIFTPKYTHYKGMMQKIAETQTSAFKTVVQGSTIFFVLKDGAKNGKMSKQEKKDQYAAAIRRTIEETFVKLSGHSTDSTGIVMSSFQNEDIADLVQLSFEYGIERVKSALYSLIEQAFFSHDAQVVENYGGKIRTLIRKELSKNLQDQVPAELTAS
>NZ_CP032527.2|WP_016764594.1|2234615_2235212_-|mechanosensitive-ion-channel
MKDIQWVQKTLFNTGKWIDISEVIIKIILIFIIAQIVIRFARSVINKIFDFRFKTKLLRYNERKEITLKKLCLSIVMYVVYFIVLITSLEAIGINMKALLAGISVAGFITGLGAQNLIKDILNGFFILFEDQFSVGDHVSINDTKGTVEEIGLRTTKIRGVDGEFYFFANSNITKVANYTLGEIPEVHKPEQIKTREE
>NZ_CP032527.2|WP_016764595.1|2234034_2234613_+|HAD-IA-family-hydrolase
MNILWDFDGTIFDTYPTIVKAFKELLTDQTISEDDILKQMKISSDIAIKHFDIEKSLFDKHFHVLEQKINPKDKPAFPHVEDVLSFADTNVIVTHKSRQSTLDILAFFNMEHYFTEIITKDDGYKRKPDSGAYAYLHDKYQLDLVIGDRELDLKPARELGIKTCAFQNDDIEADYHLTSYDQFFTTVVNKNS
>NZ_CP032527.2|WP_016764596.1|2232889_2233906_+|hypothetical-protein
MITAIIVGAVILLALIIKGIGKPRGFRLYKEELPDELGIHEGNGFEDIVHSLEDSLPKAYVQQVKQRIQGRNTKDDEVEWTFFEMKRYFLLNAVIKDVPMFSAKVDEVWHEMIMFTVDYGRFTDRFFDRFLHHQPNVDTTPSPQPDKRAFFDWMYAHLFDITGNSRLLWGKFFQHPLDKSTLQDFQRLSEDELLDRYFLRNGKWEKLQRALIQTLKEEINAARKRKKAGGSTYFKKTAKKGNVSNELLLQGFVFYSLYKATNFSSHMNELLLYKKTMYAGDTASYSGYSCSSPWEDNRHHHQHDGGHHHHDSGSSCSSSNCSSSSCSSSSCGSGCSSS
>NZ_CP032527.2|WP_013057548.1|2232397_2232817_+|hypothetical-protein
MSLSAKKILLLVLVVICLVLVVMQFINRSAEPTSEQAQETLSKLPEQETVKEKAKGDEEAHKYRVYYITIEKIENGTYSGTTKEGTGIKFSDKNLNEPIPSNLKKGDIVKAYFDLEYSTKGLVKVEKVDEMPDDDESSS
>NZ_CP032527.2|WP_016764597.1|2231498_2231990_-|hypothetical-protein
MMFALIVVVGIVALGVASFYVIKRPQGAVDPEDRKPLVSVNGHVKFAEGINQISISKIDMYDQRLVINQVAIIPFNRIQRAEFSKVVKNEKGLHGAPVQRYFGELTIHFTDKNGQETYISCETPKKNQFHLIYQYDLMKRQLNKRLGLEDLQPYLTLQEPYEL
>NZ_CP032527.2|WP_100229239.1|2230959_2231226_+|DUF4183-domain-containing-protein
MFPKKVRIFEYYTVAGGSKRIFTDQDALKEYGTQHILDPESYSYSNLFINGVLQPSSNYSVQKGLLIINTEDIPLEKSPVILQMIKVI
>NZ_CP032527.2|WP_016764599.1|2230349_2230730_-|DUF4183-domain-containing-protein
MPLQIMKLAIAATTTVTASPTVSRFFYAATATTTGAATLTIDAADFFGDTGGAATALPALATDNIYYNVYINGVLQMAGLSTYTPGATGVGSLAITVPAGSSVLTGSPIVLEVVNFAPDSDTDVQT
>NZ_CP032527.2|WP_129542287.1|2229215_2229794_+|hypothetical-protein
MKTRVELTISLLIFLIILATTLGVVISLSGLLVASIQASEQDYIGAIVGSLGNIIGGIIGVLAAVLVAAYQIRKTFELERSKGAASNSAVLRLLKTELQSNCKLIQNFKSDYMEGNKAFLKSVSIDNWERCSLQIGMETSDTTLNAISSAYRKISLLKSESKINESTYDKLIDDLSTALSNIEEDLELLKTR
>NZ_CP032527.2|WP_129542286.1|2227481_2228747_+|hypothetical-protein
MEKTELIVPEGIKDSIFQYRFVDLLKKHGKPFSGKPTIWERLQQAIENDRAFEESFNQFIIDEISNGKSRQVYICNFSIESLAILGNYTSLQAKMAAKELPTENLNRLLEADVEDGEIVYFKVKTDEMISSKVTKISLSFFNEMPVEDESEGKTILRNFPNYVWIDILPDKKYLQIKVRPAYANHIMNLQESKRVFEYYWEFLKEKFGIVFTDMSETKNTLYNMFKELTEKAEAPYTKKVESIMPEVDKQVLKLAESINLLNYKDPVDIPNRLARLFERALILSDLKSYKGYNLGKIGIVDRIDFSDQSGARVNALSGNEGIEVADIYFDTRETLDELKRLNKIWIRWFVPTEKFKLFKDTNNTLAPSGPEIEQVETRIEVMNNRVGIYFLNDQSVPKEVQDHVLSLFREFEEGEIPKTIN
>NZ_CP032527.2|WP_013083667.1|2238047_2239511_-|hypothetical-protein
MNEPSNFSPYLIKQISDAIDDNIKAKCIDFLYDSHSFFSNEKDFIEDYILNILQDTFVLENKLINPKEIRNPAYKRRQSNKKNWLQTLKKDIKAEKPNPIFEDIELAKKVMDKKVDTEHLKKLFGVEKPEDILKIKLKEVEAWAKSKKTNITDFPYLDSKMNYQIEKAFHTDFTFLIAEIILEKYNGNLSNWIDKRLNSWVEAPIFSNESHSLKTNMEVKTNSQEVVLYNDYKVDEEYFIRTIIPVNDNQTVLSKRNMVLDPKDSQIIQFALSQRDEMFYKEKTVTLDLADIVKEIYNSKGVKNYEAVEARIMKIARYHVEGVAKKKNSRDTKFAINFFQKAVIETDEVTGRRYATIVFSDDTHQGFLNQQFVQIYSDVIKKFKDNSLSSLLLYAFQKERLDCYLQEKSYTHFYPYQYFASKVRFRSKKIDVNLKLINESLAEFVSNQVLIQSYQQKLQGFEISFIPLQNYEIQDYFGGEHRETLEG
>NZ_CP032527.2|WP_016764591.1|2239824_2240706_+|Cof-type-HAD-IIB-family-hydrolase
MLLKPKAIFLDMDGTILNRSNKVSIQTKEIIDELRKQGIFVFIATGRAFDEIEELVPEGFQVDGFITSNGMAGYVGKESVFQHSLSLQLVETIIEKARANKVYYELFPYGTPRVTLKQDQSYVENEIREPKPDSVEINEWLSRKQAIKEEIDWKDSVEGSEFSKFYFFARTHEHIDKWKEKLEELKKEIDFTTSTSSKHNVEVMVANVNKATGIQQMLKHFNLPEQDILAIGDSNNDLPMFQFASYAVAMKNAPDHIQEIVDDVTEFNCDENGVSHYLSKFLLQKSTRSNPVL
>NZ_CP032527.2|WP_013083665.1|2241283_2242108_+|kinase/pyrophosphorylase
MNKRKIVYIVSDSVGETAELMVKAVLTQFSGEDIEIQNTSYVEDEGNIDNIIAEARCNEAIIAYTIVIPPLKQYLDQKAQEEGIVAIDLMTPLMSAFSQTFNKEPNLQPRLTRKLDDNYFRRVEAVEFAVKYDDGQDFRGIKRADLVLIGVSRTSKTPLSMYLAHKSLKVANIPLVPEVTPPDELFTIPKNKCIGLVITPDKLNEIRKERLKNLGLASQANYANVDRILEELDYAEKIMKRIGCPIVNVSGKAVEETAEVILSMLKKDKMKGYV
>NZ_CP032527.2|WP_016764590.1|2242228_2243731_+|malate:quinone-oxidoreductase
MSNVYKKTDVILIGAGVMSATLGSLLKELAPEWEIKVFEKLADAGEESSNEWNNAGTGHAALCELNYTSEQADGSIDITKAVRINEQFQLSRQFWSYLVSSNLIHHPQEFIMPIPHMSFVQGEKNVSFLKKRFEALSNNPLFQGMEYSDRPEKLKEWMPLVMKGRTSTEAIAATKIDSGTDVNFGALTRMLFTHLKSKRVEINYNHSVENLTRTADGSWEVKVHDIHTGKQEYHTANFVFIGGGGGSLSLLQKTGIPESKHIGGFPVSGLFMVCNNPEVVAQHHGKVYGKAKVGAPPMSVPHLDTRYIDRKKTLLFGPFAGFSPKFLKTGSNLDLINSVKPNNILTMLAAGVKEMGLTKYLIQQVLLSDEKRMEELREFIPNAKSEDWDIVVAGQRVQVIKDTEAGGKGTLQFGTEVVSSADGSVAALLGASPGASTAVHVMLEVLEKCFPQHMKKWESKIKEMIPSYGLSLVENPALFNEIHASTSQTLDLSKKELVYR
>NZ_CP032527.2|WP_013057538.1|2243977_2244637_+|2OG-Fe(II)-oxygenase
MILTNTSLLTKEQTIFNHTGNKIKLEDREIDIVARFEEPLVLVLGNVLSNEECDELIQLSKDKMQRSKIGAAREVNSIRTSSGMFFEESENELVHQIERRLSKIMGPSIEYAEGLQVLKYLPDQEYKAHHDYFTSASKASKNNRISTLVMYLNDVEEGGETYFPKLGLSVSPTKGMAVYFEYFYSDAELNDRTLHGGAPVIKGEKWVATQWMRKQKIRS
>NZ_CP032527.2|WP_016764589.1|2245057_2245882_+|thermonuclease-family-protein
MKEIKAIICTMLAMFMLLLTGCSDEQASHSSTSSADTKQAVQVEDSSDQEEDHSPSKANREDVVGEAATVERVVDGDTLKVKMLNGKRDRVRLLLVDTPETKHPKLGVQPFGPEASAYTKKRLEGQEITLEFDVQERDQYGRLLAYVWIDNELYNEELLAKGLARVAVFPPNTKYVDEFKKIQEQARKSEKGIWSIENYAQEKGYNTDAVKNQASSKQKDTQSAESCEGKIKGNQNSKIYHVPTGAHYNQTMNHVIWFCTEKDAQEAGYKKAKN
>NZ_CP032527.2|WP_080621434.1|2245920_2246103_-|hypothetical-protein
MDDDYEKTPSAERYYGKCMGIFSRNSFTSASAAHMAPASSYTDWSLFVGWYLATPIQILT
>NZ_CP032527.2|WP_016764587.1|2246249_2246804_+|GNAT-family-N-acetyltransferase
MKIRKARKEDASAVTELLYDMLGSIARSHTAATTNEEALLRLKAFILSEKNRYSYHHITIAEVEEKVVGLMLCYEGSMLQTLYEPVKRFVRAKLNNPAWEIDIETEHGDYYIDSLCVDEAYRGKGIGTALLNVAKQEAKKRKMFLSLNVEYNNVEAKKLYQRIGFQEHKTIFIDKKPFFYMKTA
>NZ_CP032527.2|WP_016764586.1|2247001_2247562_+|hypothetical-protein
MNIRDLPFNMSYRFNEQLREVPVNPHQMKQGIIYLKKRALEEEDECAAAKTYGHIGVYERILGELTSSERHLLLAIYLYDRYADTIGEFLNTIRLGHTYHWQEQWDKANETFQLLIEQLKADEDLHIYEDFVYQHYGKCLLDQRVVSRAHHYFQRALEIRLKKGDKELIESTNSCIRLCLNKLKHS
>NZ_CP032527.2|WP_016764585.1|2247760_2248591_+|YitT-family-protein
MSKTVKDVIFLLIGSFVFSLAVNMFVIPIGLGEGGVTGISIILYYTTHLSTGITNFILNGILLIVGYKFLEKKTIVYTMITIIATSIFLHVTEGWGLHLHEELIGMVFAGVLLGVGIGMILRVGGTTAGSAIIARILNKFLNWKVSHALLIVDLLVVLASYFIIGIEKLLFTIVMLYITTKVIDFVIEGFDAKKAVTVISSNKNEVADQINEQLDRGVTILNGRGNYTKESKEILYVVINKQELIKLKKLIKKIDDEAFVIVHDVRDVIGKGFLSA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP032527_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP032527_7

4791192-4791290

Orphan

Consensus_repeat	Method
TGCTTGAGCATTTTGTTGTTTCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP032527_7

>merge|NZ_CP032527|7|4791192-4791290|CRISPRCasFinder
AGCTTGTGCGTTTTGTTGTCTCACTTCTTGAGCACTTGTTTCGCTAGCAAATTCAGTACCGAAGTTGTTTTTAGATGCTTGAGCATTTTGGCTTTTGTT

>NZ_CP032527|7|7|4791192-4791290|CRISPRCasFinder
AGCTTGTGCGTTTTGTTGTCTCAC	TTCTTGAGCACTTGTTTCGCTAGCAAATTCAGTACCGAAGTTGTTTTTAGA
TGCTTGAGCATTTTGGCTTTTGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP032527.2\|WP_016762866.1\|4792664_4793759_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP032527.2\|WP_013055154.1\|4795681_4795996_-\|YfhH-family-protein	unknown	unknown	gnl\|CDD\|378063
NZ_CP032527.2\|WP_016762871.1\|4783858_4784872_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213234
NZ_CP032527.2\|WP_013055163.1\|4789967_4790504_-\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|184219
NZ_CP032527.2\|WP_013081541.1\|4797021_4797831_-\|recombination-regulator-RecX	unknown	unknown	gnl\|CDD\|237619
NZ_CP032527.2\|WP_016762870.1\|4785074_4786373_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|183493
NZ_CP032527.2\|WP_016762863.1\|4797928_4798831_+\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|187553
NZ_CP032527.2\|WP_016762864.1\|4796078_4796732_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187643
NZ_CP032527.2\|WP_013055171.1\|4781253_4781724_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NZ_CP032527.2\|WP_016762867.1\|4791540_4792290_-\|enoyl-[acyl-carrier-protein]-reductase-FabL	unknown	unknown	gnl\|CDD\|236145
NZ_CP032527.2\|WP_026106492.1\|4793998_4794979_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|224899
NZ_CP032527.2\|WP_013081552.1\|4783074_4783866_-\|daunorubicin-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226953
NZ_CP032527.2\|WP_016762865.1\|4795447_4795603_+\|small,-acid-soluble-spore-protein-K	unknown	unknown	gnl\|CDD\|285399
NZ_CP032527.2\|WP_014461824.1\|4790699_4790960_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372951
NZ_CP032527.2\|WP_026106493.1\|4782279_4783065_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226218
NZ_CP032527.2\|WP_013081550.1\|4786922_4788011_+\|aromatic-acid-exporter-family-protein	unknown	unknown	gnl\|CDD\|226614
NZ_CP032527.2\|WP_013081554.1\|4781793_4782186_-\|two-pore-domain-potassium-channel-family-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016762869.1\|4788046_4789798_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP032527.2\|WP_014461827.1\|4792406_4792631_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_013055156.1\|4795042_4795312_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379438

Protein	Function_ID	Function_description	E-value
NZ_CP032527.2\|WP_016762866.1\|4792664_4793759_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	1.12282e-150
NZ_CP032527.2\|WP_013055154.1\|4795681_4795996_-\|YfhH-family-protein	gnl\|CDD\|378063	pfam08838, DUF1811, Protein of unknown function (DUF1811). This is a bacterial family of uncharacterized proteins. Some of the proteins are annotated as being transcriptional regulators. The structure of one of the proteins in this family has revealed a beta-barrel like structure with helix-turn-helix like motif.	5.92623e-60
NZ_CP032527.2\|WP_016762871.1\|4783858_4784872_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213234	cd03267, ABC_NatA_like, ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA. NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.	1.42854e-121
NZ_CP032527.2\|WP_013055163.1\|4789967_4790504_-\|DUF402-domain-containing-protein	gnl\|CDD\|184219	PRK13662, PRK13662, hypothetical protein; Provisional.	2.65481e-127
NZ_CP032527.2\|WP_016762870.1\|4785074_4786373_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|183493	PRK12389, PRK12389, glutamate-1-semialdehyde aminotransferase; Provisional.	0
NZ_CP032527.2\|WP_016762863.1\|4797928_4798831_+\|TIGR01777-family-protein	gnl\|CDD\|187553	cd05242, SDR_a8, atypical (a) SDRs, subgroup 8. This subgroup contains atypical SDRs of unknown function. Proteins in this subgroup have a glycine-rich NAD(P)-binding motif consensus that resembles that of the extended SDRs, (GXXGXXG or GGXGXXG), but lacks the characteristic active site residues of the SDRs. A Cys often replaces the usual Lys of the YXXXK active site motif, while the upstream Ser is generally present and Arg replaces the usual Asn. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.21017e-139
NZ_CP032527.2\|WP_016762864.1\|4796078_4796732_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187643	cd08939, KDSR-like_SDR_c, 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR. These proteins include members identified as KDSR, ribitol type dehydrogenase, and others. The group shows strong conservation of the active site tetrad and glycine rich NAD-binding motif of the classical SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.21581e-56
NZ_CP032527.2\|WP_013055171.1\|4781253_4781724_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	5.31486e-80
NZ_CP032527.2\|WP_016762867.1\|4791540_4792290_-\|enoyl-[acyl-carrier-protein]-reductase-FabL	gnl\|CDD\|236145	PRK08063, PRK08063, enoyl-[acyl-carrier-protein] reductase FabL.	3.82971e-172
NZ_CP032527.2\|WP_026106492.1\|4793998_4794979_+\|metal-dependent-hydrolase	gnl\|CDD\|224899	COG1988, COG1988, Predicted membrane-bound metal-dependent hydrolases [General function prediction only].	3.50396e-35
NZ_CP032527.2\|WP_013081552.1\|4783074_4783866_-\|daunorubicin-ABC-transporter-permease	gnl\|CDD\|226953	COG4587, COG4587, ABC-type uncharacterized transport system, permease component [General function prediction only].	2.41995e-29
NZ_CP032527.2\|WP_014461824.1\|4790699_4790960_-\|hypothetical-protein	gnl\|CDD\|372951	pfam14182, YgaB, YgaB-like protein. The YgaB-like protein family includes the B. subtilis YgaB protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	8.73208e-20
NZ_CP032527.2\|WP_026106493.1\|4782279_4783065_-\|ABC-transporter-permease	gnl\|CDD\|226218	COG3694, COG3694, ABC-type uncharacterized transport system, permease component [General function prediction only].	3.08113e-45
NZ_CP032527.2\|WP_013081550.1\|4786922_4788011_+\|aromatic-acid-exporter-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	3.54796e-67
NZ_CP032527.2\|WP_013055156.1\|4795042_4795312_-\|hypothetical-protein	gnl\|CDD\|379438	pfam14043, WVELL, WVELL protein. This family includes the B. subtilis YfjH protein, which is functionally uncharacterized. This is not a homolog of E. coli YfjH, a synonym for IscX, which belongs to pfam04384. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length and contain a highly conserved WVELL motif.	7.28774e-43
NZ_CP032527.2\|WP_016762869.1\|4788046_4789798_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP032527.2\|WP_013081541.1\|4797021_4797831_-\|recombination-regulator-RecX	gnl\|CDD\|237619	PRK14135, recX, recombination regulator RecX; Provisional.	8.10118e-120
NZ_CP032527.2\|WP_016762865.1\|4795447_4795603_+\|small,-acid-soluble-spore-protein-K	gnl\|CDD\|285399	pfam08176, SspK, Small acid-soluble spore protein K family. This family consists of the small acid-soluble spore proteins (SASP) belonging to the K type (sspK). The sspK are unique to the spores of Bacillus subtilis and are expressed only in the forespore compartment of sporulating cells of this organism. The sspK gene is monocistronic and transcription is primarily by the RNA polymerase with the forespore-specific sigma factor, sigma-G. Mutation deleting sspK results in loss of SspK from the spore but had no discernible effect on sporulation, spore properties or spore germination.	2.11098e-16

>NZ_CP032527.2|WP_014461824.1|4790699_4790960_-|hypothetical-protein
MKKFDQLVTQQLETMDQLLFLQSEIERCQEIEGELVKLHEEAKLHSVQDEISEMKLKLKEIQLTFEAQTEDIIRTYKSEGACSTLA
>NZ_CP032527.2|WP_013055163.1|4789967_4790504_-|DUF402-domain-containing-protein
MGIPVEGETIQIHSYKHNGHIHRVWDRTTVLKATNNLVIGGNDRTVVTESDGRTWVTREPAICYFHAQQWFNVIGMIREDGIYYYCNISSPFIYDDNEALKYIDYDLDIKVYPDMTYTLLDEDEYEKHRKEMNYPEVIDRILHNHVEELKGWIRQRKGPFAPDFIDIWYERFLTYRHS
>NZ_CP032527.2|WP_016762869.1|4788046_4789798_-|ABC-transporter-ATP-binding-protein
MGSIRRYMKFVQPYKWQIVGTVLIGIIKFAIPLLIPLLLKYVLDDIVNGHGMSSSEKVHKMVTIMGISFVVFLVLRPPIEYYRQYYAQWVSSKVLYDIRDQLFSHIQKLSLRYYANTRAGEVISRVINDVEQTKNFVITGLMNVWLDMMTIVIAIVIMFTMNVPLTLVSIILLPVYAFSVKYFYSRLRHLTRVRSQALAEVQGHLHERVQGISVIRSFAIEPHEQKQFDKQNSNFLQKAINHTNWNAKTFAVVNTITDLAPLIVITFAGYQVITESLSVGTMVAFVAYIDRLYNPLRRLVNSSTTLTQSVASMDRVFEFIDEEYDITDKKDAKECTELHGKVQFEHVSFAYEEEEKPVIHDINLDVEKGKSVAFVGMSGGGKSTLISLIPRFYDVTEGKILIDDIDIKTYKVRSLRDKIGIVLQDTVLFSDTVKNNILLGKPGATDEEVIAAAKAANAHDFIMNLPEGYDTKVGERGMKLSGGQKQRISISRVFLKNPAILIFDEATSALDLESEHYIQEALAELAKDRTTFIVAHRLSTITHVDEIVLLENGRVVERGSHEELIKKKGHYYQLFNVQQLDTI
>NZ_CP032527.2|WP_013081550.1|4786922_4788011_+|aromatic-acid-exporter-family-protein
MKLGARILKTGIAITLSLLLGEFLSLPSPIFAAIAAVFAIQPSIYRSYLTILEQIQANVIGAASAVCFGLIFGTHPIIIGFTAVVVIAVNLKLRINNTIGLALVTVIAIMENPGDNFVEYALIRFGTVLLGVFSAFIVNLIFIPPKYETRLYYKIVSTTEEIIKWIRMNLYHASEHTLLKEDIEKMKDNVAKMNQIFDFYKEERTYSTKKRFVKSRKLVLFRQMITVTTRALTTLKLLHRVENDLQVMPQQFQDLIKSEVECLLMYHEQVLLKFIGKLRVQPTTTVPNEACVGKRALIDKFMQYKIYDNDEENKVIYHIFPLISVIIEYSEELEHLDKLIDTFQNYHKDANSFDINHQRQED
>NZ_CP032527.2|WP_016762870.1|4785074_4786373_+|glutamate-1-semialdehyde-2,1-aminomutase
MQFTKSEQLHAEALEHIVGGVNSPSRSYKAVGGGAPVAMEKASGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITKAAETGVLYGTPTAHEVTFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRDKIIKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPKSIANEVITVPFNDIEPYKEALEKWGDQIAAVLVEPIVGNFGIVEPETGFLEQVNELTHEAGALVIYDEVITAFRFMYGGAQDLLGVKPDLTAFGKIIGGGLPIGAYGGKKEIMEKVAPLGPAYQAGTMAGNPASILSGIACLEVLKQEGVYEQLDKLGAMLEEGILKHARTYNMPITINRLKGALTVYFTTETVKNYEQAENTDGELFARFFKLMLHQGVNLAPSKYEAWFLTTAHTEQDITDTLEAVEKAFKRLSEER
>NZ_CP032527.2|WP_016762871.1|4783858_4784872_-|ATP-binding-cassette-domain-containing-protein
MKNAIEVNQLRKEFKAYSSRSGLKGAFRDLFTRNYRVMKAVNDISFTVKQGEMVGYIGENGAGKSTTIKMLTGILTPTSGDITVNGMNPHKEREKFAQTIGVVFGQRSQLWWDIAVQESFRLLKKVYKVSDEDYNAHMEHVIQTLDIGPLLDKPVRKLSLGQRMRCELAAALIHNPPLLFLDEPTIGLDVLVKLKIRQFLKEINEKYNTTILLTTHDLADIEALCERVVMLDEGSIIYDGSLQKLRSNWGDLKQVTFEFGAAPNKEQLKLLTQGMPVNWIEGDQKYLWTAQLQNKGDLMSQLIAKVVAKHEISDINIEEISTEEIIRNIYEEGVVNG
>NZ_CP032527.2|WP_013081552.1|4783074_4783866_-|daunorubicin-ABC-transporter-permease
MDKYIEMIRIRFLMMLAYRTNYYSGILIYAINIGAYYFLWSAIYGGKENIQGLSITQMTTYVAVSWMARAFYFNNIDREMATEIKDGKVAVELIKPYSYLGMKTMQGLGEGIFRLLFFSVPGMIIVAFLFPVQFSANAATWLYFGLSLIFSFIINTQINLLTGITTFFLFNNDGLIRAKRVVIDLFSGLLLPISFYPFWAQHIMSYFPFQAISYIPSMIFTNGFKGQEVINALITQAVWSGLLFIPIACLWNIAKKKMVIQGG
>NZ_CP032527.2|WP_026106493.1|4782279_4783065_-|ABC-transporter-permease
MFYFSIFFQYVGQYMKTRLQYRTDMVVEIISDLLFQTVNLIFILVVFGHTQSLHGWSREEIIFIYGFFLVPFAIFSSFFNIWDFNERYIVKGEMDRILTRPIHSLFQVILERMELESLFGGVTGIAVMAYAASSLHLHFQWYDVFIFLLFILGGALVYAGIFIALASIGFWSDARTSIMPTIYNIGNYGRYPVDIYNNVIRYVLTWILPFAFVGVYPAAYFLGRSEWYGYAFLTPVMGIVFFVISIFLWNTGVKKYRGAGN
>NZ_CP032527.2|WP_013081554.1|4781793_4782186_-|two-pore-domain-potassium-channel-family-protein
MVIFLILVIIVFVIGSMKFLFEKELGEFHFFSIGHFFVLFYSYITVLLGFSLIYTVCEMGSIPVLSGGFEHEGHYFYTLFNSMYFSAATLFSVGYGDMYPVGIGKLFATFEAFIGYIMPAIFVMRTVTRT
>NZ_CP032527.2|WP_013055171.1|4781253_4781724_-|thioredoxin-dependent-thiol-peroxidase
MTAVVGEKAPDFVLMSTNGEQVSLASMKGKNVVLYFYPKDMTPGCTTEACDFRDQHENFEELDAVILGVSPDPIDKHHKFIDKHGLPFLLLADEDHSVAEEYGVWTLKKNFGKEYMGIERSTFIINKEGMLVKEYRKVRVKGHVEEALSFIKEKMA
>NZ_CP032527.2|WP_016762867.1|4791540_4792290_-|enoyl-[acyl-carrier-protein]-reductase-FabL
MSQKVALVTGSSRGIGKEIALRLAKEGYDIVLNYARSKSAAQEVAEEIKALGREALVVKANVGKVEKIKEMFEQIDEAFGRLDVFVSNAASGVLRPIMELEETHWNWTMDINSKGYLFCAQEAAKRMEKVGGGKIVTISSLGSIRYLENYTTVGVSKAAVEALTRYLAVELAPKNIVVNAVSGGAVDTEALKHFPNRDELLDDARKHTPAGRMVEPKDMVDAVMFLVSDQANMICGQTLIIDGGRSLLM
>NZ_CP032527.2|WP_014461827.1|4792406_4792631_+|hypothetical-protein
MYVGRDMTALSMISKSEWKDSELAFFHHSLQQMTPYLNAEGQSIHQQIIKEIEARGGLQRHEADYTHGTHVSYD
>NZ_CP032527.2|WP_016762866.1|4792664_4793759_-|A/G-specific-adenine-glycosylase
MKQSKDIVQNFDIRAFQDDLISWFEQEQRILPWRQDQDPYKVWVSEIMLQQTRVDTVIPYFNNFISKFPTIKDLAYANEDDVLKAWEGLGYYSRARNLQTAVREVHEQYGGEVPNTPAEISKLKGVGPYTTGAILSIAYGVPQPAVDGNVMRVLSRILSVWDDIAKPKTRKLFEDIVHEIISKDNPSYFNQGMMELGAIVCTPTSPSCLLCPVREHCRAFEEGVQNELPVKSKKKAPRALQLAAAVIRDEDGNYLIHKRPSKGLLANLWEFPNIEVDLSIAPDHQQLQAFIQNEYGADIKINAPFTTIQHVFSHIVWNVTVYEAELVSDISALKNLKVVSEKDLEQYAFPVSHQKILKEYLLVK
>NZ_CP032527.2|WP_026106492.1|4793998_4794979_+|metal-dependent-hydrolase
MDTGTHIAMGIALGGLATLDPTVSANTATLDAVMIGVMAGSLAPDLDTVLKLRNNAQYIRNHRGITHSIPAVILWPLLIVLILSLLLPGANLLHLWMWTFAGVIIHVFVDIFNAYGTQALRPFTNKWIALGVINTFDYVIFSAHVLAILIWFIGAEPGPTFITLYVLLAFYYGLRFYMRHQIAKKLRKQFPDVIKLNISPTLRFTHWHLAVTTEKYFHVGRAIGEEIFIYDTFDKVPIPESAVIEVAKKDENLSAFLSFSPIYRWELDEYNDHIEVRFIDLRYRSKDYYPFVAVVQLDYDLNIICSYTGWIFSEKKLRKKLDYLPH
>NZ_CP032527.2|WP_013055156.1|4795042_4795312_-|hypothetical-protein
MNDIFERLTNQLLNKNSSLSYAQARTWVELFWEDFESSYAKAGYDYKGKEATEKVVTMYINSYGDKLHEIAVKNPKYQHLLNNDDYLKH
>NZ_CP032527.2|WP_016762865.1|4795447_4795603_+|small,-acid-soluble-spore-protein-K
MRNKAKDFTNQHHTKLEGEPRAKAEYASKRANGTINTHPQERMHASNEREE
>NZ_CP032527.2|WP_013055154.1|4795681_4795996_-|YfhH-family-protein
MSEKRYSDMTTYELQQEIGSLQEKARKAEQLGMVNEYAVLERKVTMARSYLLDPETFKAGEVYEIQGDPGSYFKIDYMNGVFAWGFRLGSPQNEEALPISMLKK
>NZ_CP032527.2|WP_016762864.1|4796078_4796732_+|SDR-family-NAD(P)-dependent-oxidoreductase
MKTVLITGGATGLGKELAKLYAKDYNVILAGRNQHKLKEAQHELGDNVYTMSVDITKYEEVGKSVEKLLMQHSVDILINNAGIGHFGPLTDYTKQAIDEVIDTNVKGTIFLTQALMPHLLTRPEPKVMNIISTAGLRGKANESVYVASKFGVRGFTESLKVEYQDTSLHVIAAYMGGMNTPFWDHNNHIKDKSRLRSASEIAEIIYKQQNDSEDILF
>NZ_CP032527.2|WP_013081541.1|4797021_4797831_-|recombination-regulator-RecX
MPVVTKITTQKNSGERYNVYLDYGKGEEFGFGVDENVLIKYDLKKGRELDEFELTEIQYADDEKKAYNLAITYLSYRMRSEKEVHDYLKKKEINSTIIQQVIQKLVSHRYLNDEEFAKAFVLTQMNTTSKGPSVIQRELKEKGISDSTITLSLCEYPEEQQIQTAVKLIEKLKGKYKKLSQVMMKQKMEQALAVKGYSFSIIQEAFQRTNTEKESDEAWEALQYQGMKAHRRFSKYEGWEYQQKMKQALYRKGFSIDQIQSFLDSIEEE
>NZ_CP032527.2|WP_016762863.1|4797928_4798831_+|TIGR01777-family-protein
MKIVIAGGTGFVGKALTKHFLTQKHYVYILTRNADKAARDPKLKYVEWMQESSQPEEHVEGADVFINLAGVSLNSGRWTDERKKAIVESRLSSTQEILRIMAALPEKPSLYVNASAVGYYGTSTTETFTEASPSIGTDFLAETVKKWENEALKAMELNIRTVLTRFGVILGKDGGALPSTALPYKLFAGGTVGSGEQWMSWVHLQDVVKIIDYCIHTKQIEGPVNVTAPNPVQMKEFGKTIGKVLNRPHWMPVPSFGLQLLMGEMSMIILKGQRVLPEKLIQQNYIFTYTVLEDALRDLL

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Crispr_ID: NZ_CP032527_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP032527_8

4844296-4844381

Orphan

Consensus_repeat	Method
TCCGTTGGCGTCTCTCCACCTTGATT	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NZ_CP032527_8

>merge|NZ_CP032527|8|4844296-4844381|CRISPRCasFinder
TCCGTTGGCGTCTCTCCACCTTGATTCGGATCTGGCTGAGTTCCGTCACCTTCCCCAGGGTCCGTTGGCGTCTCTCCGCCTTGATT

>NZ_CP032527|8|8|4844296-4844381|CRISPRCasFinder
TCCGTTGGCGTCTCTCCACCTTGATT	CGGATCTGGCTGAGTTCCGTCACCTTCCCCAGGG
TCCGTTGGCGTCTCTCCGCCTTGATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP032527.2\|WP_016762831.1\|4839928_4841083_-\|ribonuclease	unknown	unknown	gnl\|CDD\|225231
NZ_CP032527.2\|WP_016762826.1\|4851354_4851594_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227704
NZ_CP032527.2\|WP_016762832.1\|4838185_4839823_-\|family-14-glycosylhydrolase	unknown	unknown	gnl\|CDD\|366599
NZ_CP032527.2\|WP_016762836.1\|4833103_4834660_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP032527.2\|WP_016762823.1\|4857044_4857797_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912
NZ_CP032527.2\|WP_016762834.1\|4835914_4837252_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|379358
NZ_CP032527.2\|WP_013081504.1\|4841372_4841849_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016762828.1\|4845544_4850023_-\|type-VII-secretion-protein-EssC	unknown	unknown	gnl\|CDD\|274860
NZ_CP032527.2\|WP_013081499.1\|4852807_4853407_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|377587
NZ_CP032527.2\|WP_013055105.1\|4851687_4851981_-\|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl\|CDD\|274862
NZ_CP032527.2\|WP_016762827.1\|4850035_4851340_-\|type-VII-secretion-protein-EssB	unknown	unknown	gnl\|CDD\|188441
NZ_CP032527.2\|WP_016762830.1\|4841899_4842397_-\|type-VII-secretion-protein-EssA	unknown	unknown	gnl\|CDD\|375148
NZ_CP032527.2\|WP_016762833.1\|4837620_4838136_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|237597
NZ_CP032527.2\|WP_013055102.1\|4853516_4853834_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016762825.1\|4854085_4855291_-\|DEAD/DEAH-box-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|223587
NZ_CP032527.2\|WP_013055104.1\|4852353_4852746_-\|SseB-family-protein	unknown	unknown	gnl\|CDD\|377787
NZ_CP032527.2\|WP_016762839.1\|4830724_4831810_-\|nitric-oxide-synthase-oxygenase	unknown	unknown	gnl\|CDD\|376957
NZ_CP032527.2\|WP_016762835.1\|4834854_4835751_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP032527.2\|WP_016762824.1\|4855656_4856967_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|236901
NZ_CP032527.2\|WP_016762838.1\|4831909_4832842_-\|D-2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240625

Protein	Function_ID	Function_description	E-value
NZ_CP032527.2\|WP_016762831.1\|4839928_4841083_-\|ribonuclease	gnl\|CDD\|225231	COG2356, EndA, Endonuclease I [DNA replication, recombination, and repair].	1.23468e-59
NZ_CP032527.2\|WP_016762826.1\|4851354_4851594_-\|hypothetical-protein	gnl\|CDD\|227704	COG5417, COG5417, Uncharacterized small protein [Function unknown].	1.37015e-28
NZ_CP032527.2\|WP_016762832.1\|4838185_4839823_-\|family-14-glycosylhydrolase	gnl\|CDD\|366599	pfam01373, Glyco_hydro_14, Glycosyl hydrolase family 14. This family are beta amylases.	0
NZ_CP032527.2\|WP_016762836.1\|4833103_4834660_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NZ_CP032527.2\|WP_016762823.1\|4857044_4857797_-\|STAS-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	2.05565e-15
NZ_CP032527.2\|WP_016762834.1\|4835914_4837252_-\|transcriptional-regulator	gnl\|CDD\|379358	pfam13749, HATPase_c_4, Putative ATP-dependent DNA helicase recG C-terminal. This domain may well interact selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	1.83596e-08
NZ_CP032527.2\|WP_016762828.1\|4845544_4850023_-\|type-VII-secretion-protein-EssC	gnl\|CDD\|274860	TIGR03928, T7_EssCb_Firm, type VII secretion protein EssC, C-terminal domain. This model describes the C-terminal domain, or longer subunit, of the Firmicutes type VII secretion protein EssC. This protein (homologous to EccC in Actinobacteria) and the WXG100 target proteins are the only homologous parts of type VII secretion between Firmicutes and Actinobacteria. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP032527.2\|WP_013081499.1\|4852807_4853407_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	0.000372258
NZ_CP032527.2\|WP_013055105.1\|4851687_4851981_-\|WXG100-family-type-VII-secretion-target	gnl\|CDD\|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.56462e-22
NZ_CP032527.2\|WP_016762827.1\|4850035_4851340_-\|type-VII-secretion-protein-EssB	gnl\|CDD\|188441	TIGR03926, T7_EssB, type VII secretion protein EssB. Members of this family are associated with type VII secretion of WXG100 family targets in the Firmicutes, but not in the Actinobacteria. This protein is designated YukC in Bacillus subtilis and EssB is Staphylococcus aureus. [Protein fate, Protein and peptide secretion and trafficking].	2.22184e-117
NZ_CP032527.2\|WP_016762830.1\|4841899_4842397_-\|type-VII-secretion-protein-EssA	gnl\|CDD\|375148	pfam17355, DUF5383, Family of unknown function (DUF5383). This is a family of unknown function found in Bacillales. Members of this family are predicted to contain one trans-membrane region.	5.23536e-41
NZ_CP032527.2\|WP_016762833.1\|4837620_4838136_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|237597	PRK14054, PRK14054, peptide-methionine (S)-S-oxide reductase.	6.94464e-92
NZ_CP032527.2\|WP_016762825.1\|4854085_4855291_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	5.51241e-114
NZ_CP032527.2\|WP_013055104.1\|4852353_4852746_-\|SseB-family-protein	gnl\|CDD\|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	2.64916e-09
NZ_CP032527.2\|WP_016762839.1\|4830724_4831810_-\|nitric-oxide-synthase-oxygenase	gnl\|CDD\|376957	pfam02898, NO_synthase, Nitric oxide synthase, oxygenase domain.	0
NZ_CP032527.2\|WP_016762824.1\|4855656_4856967_-\|PAS-domain-S-box-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	2.01441e-57
NZ_CP032527.2\|WP_016762838.1\|4831909_4832842_-\|D-2-hydroxyacid-dehydrogenase	gnl\|CDD\|240625	cd05300, 2-Hacid_dh_1, Putative D-isomer specific 2-hydroxyacid dehydrogenase. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomains but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric. Formate dehydrogenase (FDH) catalyzes the NAD+-dependent oxidation of formate ion to carbon dioxide with the concomitant reduction of NAD+ to NADH. FDHs of this family contain no metal ions or prosthetic groups. Catalysis occurs though direct transfer of the hydride ion to NAD+ without the stages of acid-base catalysis typically found in related dehydrogenases. FDHs are found in all methylotrophic microorganisms in energy production and in the stress responses of plants.	7.80702e-116

>NZ_CP032527.2|WP_016762830.1|4841899_4842397_-|type-VII-secretion-protein-EssA
MMKPIVLNKKIGSIVLIFSLLYFPIAAAAEADDGNVEEIKPNVYKDDPINLDPESLLENKKEVGNIPEEIKDLTFEKEEDVEKESLKESLFANASAEDNTISAKAKEYNLFSSKNTSYKKDRTEQTASEKSSDLQWFYLLLIGVGVVVLFAVLIPRISPQPSVKK
>NZ_CP032527.2|WP_013081504.1|4841372_4841849_+|hypothetical-protein
MLSFDEKLAIISSFPELHRKDVSLGRVNFHYEESVYDKTVVVHHLHPNGNGFVYGGFLKGYETNDKGLVNIRDYTEEELRSIIEASIESLSTLPDTAREEAIVGNGNEQRWNGPDNATLLLVHEDDLWNVYSGLNLEAAFLSYEEAEDYLFEEGFRRL
>NZ_CP032527.2|WP_016762831.1|4839928_4841083_-|ribonuclease
MKLYALCKKTWAISLLVFVLLVSLTPVSQAAAFLSVAQALENQNNSVQTVKGYVVGQPTGTSTVITSNYPNDYALALADSSNETNTDKMVYVQIPSNLRSTFGLQSHSELRGKSLTVTGTLTPYFSHPGIKSVTSISTETGGTDPAPDPTEPTVPVEDYYRTAAEKTGNSLKTELHNIIDHHTELSYSAVWEALKKTDEDPANANNVILLYTGRSQAKSTNGGGVDDWNREHVWAKSHGDFGTAMGPGTDLHHLRPTDVSVNSTRGNLDFDNGGTEHSEALGNYFDSDSWEPRDEVKGDVARMLFYMAVRYEGDVSDEPDLELNNTVNNGTAPYHGKLSVLLQWNAQDPVDDRERRRNDIIYSDYQHNRNPFIDHPEWVNEIWN
>NZ_CP032527.2|WP_016762832.1|4838185_4839823_-|family-14-glycosylhydrolase
MKQLCKKGLAFVLMFIFVNAFILSPINGAAAVDGKSMNPGYKTYLMAPLKKVTDYTTWEAFENDLRKAKQNGFYAVTVDFWWGDMEKNGDQQFDFSYAQRFAQAARNAGIKIVPIISTHQCGGNVGDDCNVPLPSWVWNLKSDDSLYFKSETGTTNKETLSPLATDVISKQYGELYTAFAQALAPYKDVIAKIYLSGGPAGEIRYPSYTAADGTGYPSRGKFQVYTNFAKSKFQSYALTKYGSLAGINQAWGTNLTSASQILPPSDGYQFLKDGYSTSYGKDFLAWYQGALEDHTKRIGQLAHQAFDSTFNVPIGAKVAGIHWQYNNPTIPHAAEKPAGYNDYNALLDAFKTAKLDITFTCLEMTDSGNYPEYSMPKTLVRQVAGIANAKGVVLNGENALTIGSEDQYKKAAEMAFNYNFAGFNLLRFYDVINNDTLMGQFKNTLGVTPLAQTVVVKNAPTALGETVYIVGDRAELGQWDTSIYPIKLTYNSSTADWRGTVHFPASQNVQFKAIVKRADGSLKAWQPSQQYWSVPSTTTTYTDNW
>NZ_CP032527.2|WP_016762833.1|4837620_4838136_+|peptide-methionine-(S)-S-oxide-reductase-MsrA
MEKATFAGGCFWCMVTPFEELEGIHGIVSGYMGGTVDNPTYEQVKSGTSGYYEVVQITFDPEVFPYKRLLDLYWPQIDPTDDGGQFQDRGSQYRTAIFYHNDSQKQAAEETKLEVAESGRFKKPIVTSILPASTFYEAEEYHQDFHKKNPKHYKEDRAKSGRDEFIETNWK
>NZ_CP032527.2|WP_016762834.1|4835914_4837252_-|transcriptional-regulator
MLQDNLILEHYGLNELNFDTIKSYRDRFAEVKPAHPWNALETKEFLYKVGAWGKVRDTHKEGVTLAGLLLFSEERIITEVLPQYFLEYRESKGNEEWTGRFTSQDGTWSGNIFDFYFHIHEIVRNSEPQPSIASSLTEVLINMLIHADYNGEGGVILEKQPSHYVFSNPGLLLVPTDSVFSNTVSQLRNPNIVKLFSLLGLCERSGSGLKKVKQNWSLHHYKTPAIDQDVSMHRTVVTLSLSTQERQVSSSEKDTYHTSATDSGNNFKGVEKYQNTPENNVEIDSYNKNKYSYNKRLIEEFKSYNNDVNSYNKEDNYYNNESNLYNNDVNSYSNDQNSYNNEQEEDSSNLVNVENIDTKLWDIAALAREKKRLSPNQMEHIILELCKEKPLMLKEFAYLLERTPDGVRNNYLTKLLRKGQLQLKYPNQPNHPKQAYLFNKKDIEK
>NZ_CP032527.2|WP_016762835.1|4834854_4835751_-|hypothetical-protein
MKSKCVLIFLVVVWLFNMGKGIGCGSKVNAEINIPLSTWVWDTKKWMLNQEAILEKLQEKKVTNVYLQIDTHLSPSVYRHFIQQAQAQGISVYALDGAPYWIGPSGIEEQEAFFNWITAYQAQADEPQQFLGVHLDVEPYLYKSWENNRAKSILQYQYVISQAAVQSHELHLPLAVDIPFWFDEVPFKNSNGSGLLGRWIIQYADEVTIMAYRNHADKEHGIAEITENERKWGRVLSTPIEIGVETMASDEGEYISFSAKGEEKMMQELDMLLTECQAENPPSSIAVHHFDSWLQMKP
>NZ_CP032527.2|WP_016762836.1|4833103_4834660_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSVLNVKNLSHGFGDRAIFNDVSFRLLKGEHVGLIGANGEGKSTFMNIITGKLEPDAGKVEWSKKVRVGYLDQHTALERGLSIRDVLKSAFQYLFDLEAQMNGLYEKMAEVSPEELEKLLEEVGTLQDLLTNNDFYVIDAKVEEIGRGLGLEDIGLDRDVQDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLRRYLQEYENAFILISHDLPFLNSVINLIYHMENQELNRYVGDYDDFMKVYEMKKQQLEAAYKKQQQEMADLKDFVARNKARVSTRNMAMSRQKKLDKMEVIELAQERPKPEFNFKGARTSSKLIFETSDLVIGYEEPLSKPLNLKMERGQKIALVGANGIGKTTLLKSILGEIKPISGSVEKGDYQHIGYFEQEIKTANYNTCIEEVWNEFSHFTQYEIRAALAKCGLTTKHIESKVEVLSGGEKAKVRLCKLINNETNILVLDEPTNHLDVDAKDELKRALKEYKGSILIICHEPEFYQDVVTDVWNCESWTTKLF
>NZ_CP032527.2|WP_016762838.1|4831909_4832842_-|D-2-hydroxyacid-dehydrogenase
MNIHTILVAGRMHKELEEIIKQKQLSQTFRFMEEQDVTIEDLNWADALLSFGPTNCFEDHSFKWIHSLGAGVDRFLESGNWKKSVMLTRTVCSFGQRISEYCLSYMLAELQHHAQFQHQQKQKQWKVIEPKQLSTQTVIIYGTGEIGGRLAAVLKSFGVRVMGVSKSGNEKPSFDQVVSISKEKELLKEADWIISTMPLTHETKSYFDPKWMNVVESAYFINVGRGATVDENALVEAIEQKRIRKAYIDVFEHEPLTKESSWWDHSNIIITPHISAVTKPEEAVECFVETLQKVEQGGLPSNLVNIERGY
>NZ_CP032527.2|WP_016762839.1|4830724_4831810_-|nitric-oxide-synthase-oxygenase
MKQEELFEQARVFIETCYAELEKNEADKNKRLKEIHQQIMSLGHYDHTFEELEHGARMAWRNSNKCIGRLFWHSLNVFDKRDANTVEEIRDALFHHIEYATNDGKIRPTITVFKPKMKAKEPVRIWNHQLIRYAGYETEDGTIGDPDSVAFTEVCRNLGWEGEKTHFDVLPLVLQVNEGSPRCFDIPKHLVKEVAITHPELPEFEDLQLKWYAVPMISDMKLEIGGIDYVAAPFNGWYMGTEIGARNLADTYRYNQLPKIASMMGLNMDYNATLWKDKALVELNVAVLSSFKREGVSIVDHHTAAQQFHLFEEREQKSGREVTGNWTWLIPPVSPATTHIFHKPYKNKVLSPNYFYQDAAY
>NZ_CP032527.2|WP_016762828.1|4845544_4850023_-|type-VII-secretion-protein-EssC
MNMLWVVSGQTYQQLPVDFKTFRQATVGNTQHQTFTFSYPFEKGQMTLSSEKNGRLLISYGEKRIAELSVSESFVWREQGHALTFVLTDTAVKEAVYYIDYGSEVSFSTSDETADVYQQKEKCVVEPKEGFYLSKINGKWKVFYNQEPLYLNGHRLEENTNLQPGDLILWSSMTIQLIEKDLLKIQSCYDYASKLPTTAQPISEMKKKYPVYRRTPRMIYDLPNDKVSLSFPSQDNDENNRSLWLTILPPLVMLLVMGTVSIIQPRGIFIIISVMMFTTTLIVSTVQYFKDKKQRKKRQERRRRIYTKYLENKREELQELVSVQRDVLSYHFPTFERMKYLTEQISDRIWERTVESSDFLQVRLGTGTVPGSYQISLNSGDMANREIDDLLEQSQHMEKVYREVKNAPVTAHLGLGSIGLVGKMKTVKNELHQLVGQLAFSHSYHDVRFVFIFDEEEYKEWEWMKWLPHFQLPHSFAKGFIYNEQTRDQLLSSIYEMLRERDLDEAKGEGVFLPHFVFIITNQQLIADHVILEYLEGYHPHLGFSAIFAAETKESLTEHVHTLVRYINESEGDILIQKQKAVNIPFQLDKHTLDYNERFARMLRTLDHQVGMTNSIPNSVSFLELFKAREIGELDIVQRWQSNESAKSLAVPIGLKGKEDIVELNLHEKAHGPHGLLAGTTGSGKSEFLQTYILSLAVNFHPHEVAFLLIDYKGGGMAQPFKNMPHLLGTITNIEGSKNFSTRALASIKSELKRRQRLFDRYEVNHINDYTDLYKQGMAEEPLPHLFLISDEFAELKSEEPEFIRELVSAARIGRSLGVHLILATQKPGGVIDDQIWSNARFKVALKVQDAADSKEILKNADAASITVTGRGYLQVGNNEVYELFQSAWSGAPYMEDTYGAEDEVAIVTDLGLIPLSDVSTQQTSSKQAEAEIDVVVHKIEKTQQELAIKKLNSPWLPPLKERLLRSEYTEKRDGVFPIGLIDEPEKQSQTVYNYQLMDDGNIGIFGSSGYGKSFTVMMLLLNLAERKSPEQLHYYIFDFGNGTLLPLRQLPHTADYFLMDQMRKIEKFMTIIKQEIARRKQLFQQREVSNIKMYNALSSEELPLIFITIDNFDLVKEEMQDLEMQFTQLVRDGQSLGIYMIFTATRVNSIRQSLMNNLKTKVVHYLMDHSEAYSILGRTPYALESIPGRAIIKTDQPYFAQLFLPAEGKDDFEIFDAVKLHIQRLKNQYADAIVPEPVPMLSSKLVLVEFMTDRRVIREKGVIPLGLDEEFVRPVHMNFTKNKHCIVMGQTQKGKTNVVKVILQTALEQGVKQIGLFDSVDRGLSSYAAEEQVVYMETKEQIIDWLDLTEERLQRREIKYLEAVQEGTVHSLSFAPIMLVVDGFVRFQQNLDSVLQDRITKLMKNYSHLGFNLIVAGNNNEFSKGFDALTTEVKQISQAVLLMKKTEQSLFTLPYDRKEADINPGFGYYIKSGKETRIQIPLCVSERKILT
>NZ_CP032527.2|WP_016762827.1|4850035_4851340_-|type-VII-secretion-protein-EssB
MSDKKPTYLEEQLEAVMTRHNNEYTFVFQKEKIRLNRSVEIEMLKDVNTAFQKEIMMSDDELKITIKPTSEFQPFTALRGKEEQQKWLFADQLIKQVKQHSFSRLHLLICPENIIFDKSLSPAFLHYGVKESLPPYESNGEQSFQELKATIAAAVDSSHTFEQYFKLYETLQLKEDAKKIMHISNEEELSQFVQHKLTQIEKHQKTLVQLPQKRWTIFKFSSVGILVLLIPALIYTFYSYFFAQPKQEAFVESNEYFLEKNYSKVVDTLEDYDIESMPKIVQYEIATSYLVNEKLGEEQKANALKTITLQSDPQYFAYWFYIGRGDNKKALEVSRLLEERSLIIYALMKYEGQLKTDNDLAADKKQEELDKVANELEEFKKENDQQEAEAAKQQEEKQAEEAQAAKQQEEEQKAAEAEKKKQEEQKKQQEDQSK
>NZ_CP032527.2|WP_016762826.1|4851354_4851594_-|hypothetical-protein
MYIEVTVDLKHYTGDRFDLRLSNYHSLKKVIEIVWQAKKITQSPKDGAWIRVSNKNLIFSGNETMINCGITTGDCIEIL
>NZ_CP032527.2|WP_013055105.1|4851687_4851981_-|WXG100-family-type-VII-secretion-target
MSGIIRVTPAELRDMAGRYTNESGQVQELVSRLDTMKNQLQDMWEGASSEAFAAQYEELKPSFVEMSNLLTKIAKQLDDSANVLEDTDNQIASQIRG
>NZ_CP032527.2|WP_013055104.1|4852353_4852746_-|SseB-family-protein
MKYTFNLLEKSLIEAMKDNKKIAQFYKTLMNSNLWLVVSSEHGASDILIAEHYVQTMKSAAYRYLPVFSSKYPIEQMLKDEKTVCVSFKDMLPVLNEEIAILLNPDTPLSKLFIPEEIRMLKEDQNYFKQ
>NZ_CP032527.2|WP_013081499.1|4852807_4853407_-|WXG100-family-type-VII-secretion-target
MEIKVNPEVLRTFAERIQHSHSQTADALQKLSWEATNLHFLSVADIDKVLDLQEELQHMIRKLDSLTENAHLLVKDTAEQMRKADGELEGSSGWTEFWSSVWSNGGTHSQDTWNDIKNLKEWNTYDNMHRTIEKPLGTLNVMWNSLSMSWEEKVVNGSTCSRTEFFTYGVIQMGLGILSQEMNPSNIMFSDSTEEVKRE
>NZ_CP032527.2|WP_013055102.1|4853516_4853834_-|hypothetical-protein
MDAIDDLFDDIERRRKSKEYSRDADQLESYLHEVQRIMEFLEEGIYLFQNSHQQYASDWSGRSKSSYEDIYNDITQSTFHLYDVRDELFQTLRLEISRLRELASA
>NZ_CP032527.2|WP_016762825.1|4854085_4855291_-|DEAD/DEAH-box-helicase
MSQFIETLQPFLQEAWKKAGFNEPTAIQTKAISEILANKDVIGESPTGTGKTLAYLLPVLHRIQPGPSHIQAVILASSHELVMQIHGEIQTWSQGSGISSAAFIGGANMKRQLEKLKKRPNIIVGTPGRLNELIKMKKLKMHEVKTIVIDEADQLFVPEHVQTVQQIVKMALSDRQILVFSATVSERTKSLAKDMMNHPLEIEVGRDELPASKVEHVYIKSEARDKVDVLRKLVRQEQMKALAFFKGIDTLIEFEEKLTFKRVEAGSLHSETKKEDRATTIKGFRKGDFPVLLATDVAARGLDIKGLTHVIHIDVPQDVDQYVHRSGRTGRSGAEGTVISLVTEREERNLKQIARELQLSLVKKELYMGEIVDEGTKEQSRTAKKPSKKPFNKKKKQKGRM
>NZ_CP032527.2|WP_016762824.1|4855656_4856967_-|PAS-domain-S-box-protein
MVKHARKVALRISIIYIIIGAVWILISDNISRTLAQGRFEVYIFFQQYKGWLFILATGIILYGLVYRRAYKLVESQQELVVKEHELQTSNQHYQSLFKHNPDGVFEISKTGEVLLANPEGEAIVGYSSEELQKMKPSALITAEEFDMCKEYFKEVLNGKGAKFEMNVINRKRERRLLRCSLLPIIVHKQVVGVFMIARDITTYRQDEELMITSEKMSVIGQMAGAVAHEIRNPLTSLKGFVQVMQASKETNDTYLEIMMSEIDRINLISSEMLILGKKQHVSFEKTNLCGILKQVVTLMEAQANLNNVSILLKETAKRPIYVSADSNQLKQVFINVIKNGVEAIMEKGHITITVEEKDTRALIHFEDNGIGMSQERIEQVGTPFYSTKEAGTGLGLAVCYKIMERHQGTMHFKSGKGKGTTVIIDMPIIERNSRLS
>NZ_CP032527.2|WP_016762823.1|4857044_4857797_-|STAS-domain-containing-protein
MSTIKYAPLPVFIMDEEMNILAQSDEAAALFGEVQHFLEIVDEDSQIKARKRLGQKKKIKTELVMHSRKAKMSLYTVNCKWEQGKAHVICVEEDSQIRILSEKIQQHTARLSETDLELLLQKERLEKAMNRVIELSGPFIHLSNNMVLIPLFGDLFEEVIMKNEHRLLRQIDEETVDRVIIDFNGIGQIDERGVASLEHLIWEFQLMGVQIYLTGVTPDHSQWLHQYHFQANVKSISNLGQAIHQFFTTA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP032527_8	8.1\|4844322\|34\|NZ_CP032527\|CRISPRCasFinder	4844322-4844355	34	NZ_CP023064	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence	347341-347374	10	0.706

1. spacer 8.1|4844322|34|NZ_CP032527|CRISPRCasFinder matches to NZ_CP023064 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence) position: , mismatch: 10, identity: 0.706

cggatctggctgagttccgtcaccttccccaggg	CRISPR spacer
tccggcaagctgagttccgtcgccttccacaggt	Protospacer
.  . * .*************.****** ****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

20684 : 31141

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013059909.1\|20684_22049_+	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	1.5e-121	52.1
WP_013085553.1\|22236_23523_+	adenylosuccinate synthase	A0A2P1EKE7	Megavirus	2.1e-69	35.9
WP_013085552.1\|24292_25000_+	response regulator transcription factor	W8CYM9	Bacillus_phage	2.4e-46	42.0
WP_013085551.1\|25006_26914_+	cell wall metabolism sensor histidine kinase WalK	W8CYF6	Bacillus_phage	3.8e-38	36.4
WP_016765986.1\|26904_28272_+	hypothetical protein	NA	NA	NA	NA
WP_016765985.1\|28258_29038_+	hypothetical protein	NA	NA	NA	NA
WP_013059903.1\|29056_29851_+	MBL fold metallo-hydrolase	A0A2I7SDH3	Paenibacillus_phage	5.4e-39	36.0
WP_034669064.1\|29908_31141_+	PDZ domain-containing protein	A0A1B1IRD3	uncultured_Mediterranean_phage	8.1e-10	30.1

DBSCAN-SWA_2

890149 : 899423

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016765493.1\|890149_890866_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.7e-47	42.2
WP_129542263.1\|890865_892638_+	HAMP domain-containing protein	A0A1V0SGX0	Hokovirus	6.4e-24	26.0
WP_016765491.1\|892779_893469_+	peptidoglycan DD-metalloendopeptidase family protein	Q8SBN9	Clostridium_phage	5.2e-14	42.1
WP_016765490.1\|893502_895077_-	phosphoglycerate dehydrogenase	A0A2H4PQU8	Staphylococcus_phage	1.0e-28	30.2
WP_013084915.1\|895672_896248_+	ECF transporter S component	NA	NA	NA	NA
WP_013059046.1\|896326_896575_-	ferredoxin	A0A127AYY7	Bacillus_phage	3.6e-18	54.1
WP_016765489.1\|896832_897882_+	ATP-dependent DNA helicase RecQ	NA	NA	NA	NA
WP_016765488.1\|897905_899423_+	ATP-dependent DNA helicase RecQ	M1PGQ0	Moumouvirus	1.7e-54	31.1

DBSCAN-SWA_3

2987098 : 2995310

Bacillus_virus(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016763994.1\|2987098_2989510_-	S8 family serine peptidase	A0A217EQY2	Bacillus_phage	1.6e-17	36.9
WP_013056909.1\|2990249_2990687_-	RNA-binding protein S1	NA	NA	NA	NA
WP_013083029.1\|2990868_2991690_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	1.1e-92	64.1
WP_016763993.1\|2991724_2992405_-	nicotinate (nicotinamide) nucleotide adenylyltransferase	G3MA22	Bacillus_virus	1.9e-40	42.8
WP_016763992.1\|2992420_2993890_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	1.1e-114	48.4
WP_016763991.1\|2993913_2994462_-	cysteine hydrolase	G3MA16	Bacillus_virus	2.3e-33	43.9
WP_016763990.1\|2994533_2995310_-	NUDIX hydrolase	A0A0E3JJF3	Streptomyces_phage	6.7e-10	41.9

DBSCAN-SWA_4

4925088 : 4933350

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013055043.1\|4925088_4925667_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.3e-29	39.2
WP_013081441.1\|4925663_4926701_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F0L1	Synechococcus_phage	1.7e-69	45.6
WP_013055041.1\|4926727_4928143_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	4.3e-55	34.6
WP_013055040.1\|4928118_4930350_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.2e-157	41.3
WP_013055039.1\|4930333_4931020_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_013055038.1\|4931016_4931268_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_013055037.1\|4931275_4931983_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3FGF0	Synechococcus_phage	1.2e-42	40.2
WP_016762771.1\|4932057_4933350_-	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	5.9e-19	25.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP032534

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CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP032531

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CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP032528

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CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

4. NZ_CP032527

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection