CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_020450	Lactococcus lactis subsp. lactis IO-1, complete genome	3 crisprs	WYL,cas3,DEDDh,csa3,DinG	0	0	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_020450_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_020450_1

684003-684106

Orphan

Consensus_repeat	Method
AGGAAGTCATTCAATCAGTGAATGAAGGAACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_020450_1

>merge|NC_020450|1|684003-684106|CRISPRCasFinder
AGGAAGTCATTCAATCAGTGAATGAAGGAACTATCAGCTTTGCGATAAGTTCTGTCAGTTGAATGCGCCCAGAGGAAGTCATTCAATCGGTGAATGAAGGAACT

>NC_020450|1|1|684003-684106|CRISPRCasFinder
AGGAAGTCATTCAATCAGTGAATGAAGGAACT	ATCAGCTTTGCGATAAGTTCTGTCAGTTGAATGCGCCCAG
AGGAAGTCATTCAATCGGTGAATGAAGGAACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_020450.1\|WP_012897406.1\|670718_671861_+\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|179997
NC_020450.1\|WP_015426051.1\|693504_695499_-\|ABC-transporter-ATP-binding-protein/permease	unknown	unknown	gnl\|CDD\|224059
NC_020450.1\|WP_010905520.1\|681337_682813_+\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NC_020450.1\|WP_015426038.1\|671850_672990_+\|glucose-1-phosphate-adenylyltransferase-subunit-GlgD	unknown	unknown	gnl\|CDD\|273966
NC_020450.1\|WP_015426045.1\|686025_687747_+\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|227320
NC_020450.1\|WP_003129639.1\|682812_683808_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224213
NC_020450.1\|WP_015426042.1\|679129_680623_+\|peptide-MFS-transporter	unknown	unknown	gnl\|CDD\|225646
NC_020450.1\|WP_042230170.1\|673084_674521_+\|glycogen-synthase-GlgA	unknown	unknown	gnl\|CDD\|234809
NC_020450.1\|WP_042230706.1\|690198_691953_+\|multidrug-efflux-ABC-transporter-LmrA	unknown	unknown	gnl\|CDD\|224055
NC_020450.1\|WP_003129644.1\|688039_688915_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_020450.1\|WP_015426047.1\|688940_689396_+\|flavodoxin	unknown	unknown	gnl\|CDD\|226982
NC_020450.1\|WP_015426050.1\|691971_692583_-\|DUF1211-domain-containing-protein	unknown	unknown	gnl\|CDD\|226078
NC_020450.1\|WP_015426036.1\|667427_668399_+\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|223852
NC_020450.1\|WP_015426037.1\|668614_670618_+\|4-alpha-glucanotransferase	unknown	unknown	gnl\|CDD\|215512
NC_020450.1\|WP_003129656.1\|695605_695824_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|370725
NC_020450.1\|WP_015426048.1\|689422_690097_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238879
NC_020450.1\|WP_042230172.1\|674609_677012_+\|glycogen/starch/alpha-glucan-phosphorylase	unknown	unknown	gnl\|CDD\|340853
NC_020450.1\|WP_015426044.1\|684163_686026_+\|thiol-reductant-ABC-exporter-subunit-CydD	unknown	unknown	gnl\|CDD\|227321
NC_020450.1\|WP_010905527.1\|692653_693298_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NC_020450.1\|WP_015426041.1\|677101_678904_+\|glycoside-hydrolase-family-13-protein	unknown	unknown	gnl\|CDD\|200477

Protein	Function_ID	Function_description	E-value
NC_020450.1\|WP_012897406.1\|670718_671861_+\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|179997	PRK05293, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NC_020450.1\|WP_015426051.1\|693504_695499_-\|ABC-transporter-ATP-binding-protein/permease	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	2.51206e-103
NC_020450.1\|WP_010905520.1\|681337_682813_+\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
NC_020450.1\|WP_015426038.1\|671850_672990_+\|glucose-1-phosphate-adenylyltransferase-subunit-GlgD	gnl\|CDD\|273966	TIGR02092, Glycogen_biosynthesis_protein_GlgD, glucose-1-phosphate adenylyltransferase, GlgD subunit. This family is GlgD, an apparent regulatory protein that appears in an alpha2/beta2 heterotetramer with GlgC (glucose-1-phosphate adenylyltransferase, TIGR02091) in a subset of bacteria that use GlgC for glycogen biosynthesis. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_020450.1\|WP_015426045.1\|686025_687747_+\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|227320	COG4987, CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
NC_020450.1\|WP_003129639.1\|682812_683808_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|224213	COG1294, AppB, Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion].	5.93602e-93
NC_020450.1\|WP_015426042.1\|679129_680623_+\|peptide-MFS-transporter	gnl\|CDD\|225646	COG3104, PTR2, Dipeptide/tripeptide permease [Amino acid transport and metabolism].	6.91434e-176
NC_020450.1\|WP_042230170.1\|673084_674521_+\|glycogen-synthase-GlgA	gnl\|CDD\|234809	PRK00654, glgA, glycogen synthase GlgA.	0
NC_020450.1\|WP_042230706.1\|690198_691953_+\|multidrug-efflux-ABC-transporter-LmrA	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.32606e-167
NC_020450.1\|WP_003129644.1\|688039_688915_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.45605e-19
NC_020450.1\|WP_015426047.1\|688940_689396_+\|flavodoxin	gnl\|CDD\|226982	COG4635, HemG, Flavodoxin [Energy production and conversion / Coenzyme metabolism].	4.09634e-56
NC_020450.1\|WP_015426050.1\|691971_692583_-\|DUF1211-domain-containing-protein	gnl\|CDD\|226078	COG3548, COG3548, Predicted integral membrane protein [Function unknown].	1.7019e-60
NC_020450.1\|WP_015426036.1\|667427_668399_+\|transcription-antitermination-factor-NusB	gnl\|CDD\|223852	COG0781, NusB, Transcription termination factor [Transcription].	5.03587e-33
NC_020450.1\|WP_015426037.1\|668614_670618_+\|4-alpha-glucanotransferase	gnl\|CDD\|215512	PLN02950, PLN02950, 4-alpha-glucanotransferase.	0
NC_020450.1\|WP_003129656.1\|695605_695824_-\|DNA-binding-protein	gnl\|CDD\|370725	pfam09855, zinc_ribbon_13, Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082). This domain, found in various hypothetical prokaryotic proteins, as well as some Zn-ribbon nucleic-acid-binding proteins has no known function.	1.0785e-33
NC_020450.1\|WP_015426048.1\|689422_690097_+\|hypothetical-protein	gnl\|CDD\|238879	cd01841, NnaC_like, NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases. E. coli NnaC appears to be involved in polysaccharide synthesis.	3.02921e-64
NC_020450.1\|WP_042230172.1\|674609_677012_+\|glycogen/starch/alpha-glucan-phosphorylase	gnl\|CDD\|340853	cd04300, GT35_Glycogen_Phosphorylase, glycogen phosphorylase and similar proteins. This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism. The allosteric control mechanisms of yeast and mammalian members of this family are different from that of bacterial members. The members of this family belong to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	0
NC_020450.1\|WP_015426044.1\|684163_686026_+\|thiol-reductant-ABC-exporter-subunit-CydD	gnl\|CDD\|227321	COG4988, CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
NC_020450.1\|WP_010905527.1\|692653_693298_-\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.27362e-46
NC_020450.1\|WP_015426041.1\|677101_678904_+\|glycoside-hydrolase-family-13-protein	gnl\|CDD\|200477	cd11338, AmyAc_CMD, Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins. Cyclomaltodextrinase (CDase; EC3.2.1.54), neopullulanase (NPase; EC 3.2.1.135), and maltogenic amylase (MA; EC 3.2.1.133) catalyze the hydrolysis of alpha-(1,4) glycosidic linkages on a number of substrates including cyclomaltodextrins (CDs), pullulan, and starch. These enzymes hydrolyze CDs and starch to maltose and pullulan to panose by cleavage of alpha-1,4 glycosidic bonds whereas alpha-amylases essentially lack activity on CDs and pullulan. They also catalyze transglycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules. Since these proteins are nearly indistinguishable from each other, they are referred to as cyclomaltodextrinases (CMDs). The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	3.32771e-178

>NC_020450.1|WP_003129639.1|682812_683808_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MTGLQLFWFIIVGVLFSGFFFLEGFDYGVGMSAITIAKDKREVEQAIGSIGPVWDLNEVWLLTAGGAMFASFPYWYASLFSGFYLILFLILVGLIFRGVTFEFRHHSHTEKGKMLWTKVLGVASFAIPFLFGLMFTSMIQGVPMDAKGNVTATFTTYVNFLSVVGGVAVMLLAWLHGLNYLALKTEGALRERAAKIANILYFVLYAGEVVFAVLLAIFTDFFEKHFIGTLVLLALIVILTLVAHLSVRAGKEMSAFLASGLTFIALVALIFQGIFPRVMIATNPAHSILIKNASSTGYTLKTMTIITLVILPFVLIYMGWTYFIFRKRIKK
>NC_020450.1|WP_010905520.1|681337_682813_+|cytochrome-ubiquinol-oxidase-subunit-I
MFTIETLARFQFAMTTIFHFFFVPLSVGMVLMTAIMETIYVKTGDEKWKKRTKFFGSIMLLSFAVGVVTGIIQEFQFGMNWSDYSRYVGDIFGAPLAVEALLAFFLESTFLGVWMFGWDKLGKKLHNATLWIVFVGTFLSSLWILAANSWMQNPVGYEVKGGRATLTSFSALLTNPQTILEFSHVATGFLVTGGFVVAGISAYQILKNREIDMFKPVLRLGLLVALIGAVGNFVAGDQQMIEVKNSQPMKFAATEGVYETTPDPAAWDMVAFFNEADHKEVFGIQIPYMLSILTYHRPSGSVEGMNEINAQLQKKYPDVAKEIGGNFFPPVTVLFWTFRIMAGLSMLMILLSALGLFWTRKKKPSLYENKFGLQVYRWMLFAPFLAITSGWLVTELGRYPWTVYGLFTIKDSVSPNVSVGSLLFSNIVYFFLFCFLGAVMVYFTLQRMKQGVEGAETAYVSLDSFSQENFASSSKEDSEIQKETDEKGVDK
>NC_020450.1|WP_015426042.1|679129_680623_+|peptide-MFS-transporter
MQNLNKTEKTFFGQPRGLLTLFQTEFWERFSYYGMRAILVYYLYALTTADNAGLGLPKAQAMAIVSIYGALVYLSTIVGGWVADRLLGASRTIFLGGVLITLGHIALATPFGLSSLFVALFLIILGTGMLKPNISNMVGHLYSKDDSRRDTGFNIFVVGINMGSLIAPLIVGTVGQGVNYHLGFSLAAIGMIFALFAYWYGRLRHFPEIGREPSNPMDSKARRNFLITLTIVVIVAIIGFFLLYQASPANFINNFINVLSIIGIVVPIIYFVMMFTSKKVESDERRKLTAYIPLFLSAIVFWAIEEQSSTIIAVWGESRSNLDPTWFGITFHIDPSWYQLLNPLFIVLLSPIFVRLWNKLGERQPSTIVKFGLGLMLTGISYLIMTLPGLLNGTSGRASALWLVLMFAVQMAGELLVSPVGLSVSTKLAPVAFQSQMMAMWFLADSTSQAINAQITPLFKAATEVHFFAITGIIGIIVGIILLIIKKPILKLMGDVR
>NC_020450.1|WP_015426041.1|677101_678904_+|glycoside-hydrolase-family-13-protein
MYYYNPWNLDYKQPFGAIKVGNSMSLRFTTDQPSVLVTCVIRRDFGKRYEFSMTKDSGGDFRVTIPFDEEPGLYFYHFEIVESSDLGETRRFYGCSGIGGEGLLYTDENDVKPYQLTVFEKEDQAPSWYREAVFYQIFPDRFYNGNENGQINHPKPNSFIYGRKTDSPFYVKEENGDIARWDFFGGNLRGIIKKIPYLKELGINAIYLNPIFSGTSNHRYDTNDYLKIDSMLGRQEDFEELIQLLHQEKMHLVLDGVFSHVGKNSLYFNINGDYGDDEGAAKNPDSPYFDWFKFENYPFEYKSWWGIKDLPEIDKDNDSFRNFIYGEKNSVLAKWNDLGIDGWHLDVADELPDSFIKGIRENLDSYSDKILIGEIWEDASNKISYGKRRNYILGGSLQAAMNYPFRDLIINLLNGHRSSQDVAYQLMTLQENYPKDIFYNNLNNLGTHDTERILTMVGEKNLSVALAMLFVLPGIPCIYYGDEAGLSGGKDPENRKYFPWDNISPKIYNAYKSWTQKRLSENSLKYGEFSTFFTDSLLGILRYTDSEVFVELINPSEDELNIEVQEITFLQNLKFLPELKKLLTEKVISGKTNLELKMKI
>NC_020450.1|WP_042230172.1|674609_677012_+|glycogen/starch/alpha-glucan-phosphorylase
MKLSKKQFKQDFEERLTSKFATDLTKAGYQEIYDALASVVKHYYANIWVADNQYKDETGKKQAYYFSIEFLPGKMLKSNLLNLGILNTVREGLNDFGIKLDEVAKIEPDMAIGNGGLGRLASCFMDSLASTGLPGNGNGIRYRYGLFKQKIVDGYQVELPDSWLNNGNPWEVRRADKAVEVTFGGEVWLEDDGKGNLIPHYKDQERVLAVPYDTPMVGFENTTVNNMCLWRSEVPEELDPKFQNLDYMRQTSMLSAELYPDDSNYDGRLLRLKQEYFFVSAGLQRILHHYKGTQKKDIRKIGDYIAVHINDTHPALCVPEFMRLLVDEYGVGWNRAWDTTLKVMSYTNHTILSEALEKWPEEMIKQLLPRIYQIIVEIDRRRTAELLPKVGATLVHNTRIIKDGQIHMANLSIIGSHSTNGVAKLHSDLLKDVELHDFYEIYPERFNNKTNGIADRRWIQIANERLSGIIDETIGKSWRHDLDELKLLKNFKNDEKTLEQIQKAKFDDKLRLAAVIKEQNGITVNPDAIFDVQVKRLHAYKRQLLNALHILKLYFDLKDNPELDMVPRVFIFGAKAAPSYHYAKSIIKVINEIANMINNDQTIKDKLKVVFMENYNVSLAEVIIPAANVGEQISLASKEASGTSNMKFMLNGALTIGTLDGANIEIFEAAGDGNNFVFGLTKDEVYEYYRNGNYNARDIYEQNPVVNRILNALIDGTVPNIKSEGREIFDSLTVYNDEYFVLRDFNDYVRAQAELEKLYRDQKAWTQASLMNIANVGRFSSDRTVREYADDIWYIKAKKE
>NC_020450.1|WP_042230170.1|673084_674521_+|glycogen-synthase-GlgA
MKVLFASSECAPFFKTGGLGDVAGALPKELAKKSEIDSVAVILPYFKNEMKEEYRSLLKDEFYDFVDVGWRHEYVGVKSLEKEGVKYYFLDNEHYFGRGQLYGYDDDGERFAFFDLALCQLLEKLDFIPDVLHVNDWQTAMVPFLLKEKYNWIKAYEKIKTVLTIHNIEFQGLMHGDALSEIFGMGMERYFEGVVRHNGMLNMLKTGILYADRVNTVSPTYAKEIQTSEFGCGLESILQYVDGKVSGILNGIDYDIYNPENDILIPYHFSEEELSGKGQMKAELQKRTGLPLNPNVPLIGMVSRLTNQKGFDLVLSQLEKVLEENVQIVLLGTGFPEIEEGFRYFSQKYPDKLSANIAFDLQFAQEIYAGSDFFLMPSAFEPCGLSQMIAMRYGTLPIVHEIGGLKDTVIPFNPISKEGTGFGFVDFEGQILLETINRALDVYGKEPKVLNKMVLSAMSKDFSWGTKAQQYIELYQEL
>NC_020450.1|WP_015426038.1|671850_672990_+|glucose-1-phosphate-adenylyltransferase-subunit-GlgD
MNNSNKMAAILSNISSSKHLSPLTEVRPIATLPFDCKYRLIDFPLSSLSNAHVDNIFMTFNEGETQSVFDHLGSGGEWGLDGFNSRYFVYIQQDFDRLREQGKDYFAQQLSFLRKSKAPYTVLLGSKFICNVDLTAVLKIHKLAGKEITTVYKKVSPDLASEYDTILRFDESGKMSNCYVNQLENPQEKEALCLNLFIVNTDWLINFIKEMQDMGELTSIARLIRVYMKNYDVNTYEYTGYMSNITNIKSFYDANMVMLDPQNFTSLLYSSQPVYTKIKNEVPTYFSENSKVENSQLGSGCIINGKVKNSLISRGVKIQDDALIEESLVFTNSEVKSGAQVKFAIIDKGVVVENNVKIIGSSEKPVVIPKGTVVTADIL
>NC_020450.1|WP_012897406.1|670718_671861_+|glucose-1-phosphate-adenylyltransferase
MAIEMLGLILAGGQGTRLGKLTKDVAKPAVPFGGRYRIIDFALSNCANSNVKNVGVITQYQPLTLNAHIGNGAPWGLNGINSGVTILQPYSSQEGSKWFEGTSHAVYQNISYIDQQNPEYVLILSGDHIYKMDYEAMLESHKEREASLTVSVMEVPLEEASRFGIMNTDDNDRIIEFEEKPKEPKSNLASMGIYIFNWKRLREVLVNGYSKGNPMEDFGGDVIPAYIEAGENVFAYRFKGYWKDVGTIDSLHQSSMEFLDLNNELNITDKSWRIYSHNDISAPQFITEKSNVKNALVGDGCYVDGTVVHSILSQNVHVQEGTVIEDSFIMSGTFIGENVTIKNAIIGENAKIGDNVEIIGENEVAVIGHGEIKGENKNEQ
>NC_020450.1|WP_015426037.1|668614_670618_+|4-alpha-glucanotransferase
MLTNNFSIEPYGEKAYHTGIAVPVFSLRTENSSGVGQFSDLKELADFAHRSGMDIIQLLPINDTSTFMDWRDSYPYRAISVFALHPIYLDIHIFWDSYTKIQQEKLLIAELELNALEKIDYEKALSLKWEYAEIIYQNSAHKFKASKDYQQFYQQNEDWLKAYAAFSYLRDINQSANFMNWGKYATYSEDFFEKLTSESNQLDLYIFVQYLLHYQLSEAVDYCHQLGIALKGDIAIGIAHDSVDAWTHPELFHLDKQAGAPPDIFAVNGQNWGFPTYNWKKMAEDGYAWWKKRLTAMSNYFDAYRLDHILGFFRIWQMPEDSVRGLLGQFSPAIALSAEEIENNYGIPLRQWGLERFINPFIKDWVIDEIFGRDNRDWIIQTFLDYIGNGNYTFQNEYNNQKKVEKAQLEDWVREGLYKLHENIILLKDDENPEKYHPRISLMQTISFREFGDDYKGRLEKLYNDYFYGRNYEFWKEKAYEKLPVLKDATNMLACGEDLGMVPANVPDVMNHLNILRLIIERMPSDNRFVSPLNEVPYLSVLTTSSHDTSPLRAWWEENHEEIQRYYNEVMGWYGEAPYYASAEIIQEIVKRHLNSNAMMVILPIQDWLAMSEQLRKEDAKSEQINIPANPYHYWNYRLHCQLETLIDNQDWTEFLKKFIKESKRAY
>NC_020450.1|WP_015426036.1|667427_668399_+|transcription-antitermination-factor-NusB
MPKTLTQHQIRQRAVQVLFSYAVQKEMATNVVSSFRENVEKLEEELSQTVRFDVDFRDERITVRKFPKGLSQPLEAIYEIYEILGLKDIEKTTVAKALAFMRDFGGYAKKMNEYEATNLFVGVMANLKLIRLFQIELDEEPVAPKVLEFFKNLPENATAEQSLETFQKTFSFLHENVLEKYTSDLFTPSTLKEELDEQLAQAENNAQSQLSELLKNTKRFVLNYDNDRPEDLEAPEYFTQLVDGVLNKKEDLEANISKYLAKTWSFSRLTLVEQAILQVSSYEILYTETPDVVAVNEAVELSKDFSDEKSSRFINGVLTNFLK
>NC_020450.1|WP_015426044.1|684163_686026_+|thiol-reductant-ABC-exporter-subunit-CydD
MIDKSLFELPGVRRMFPILGILAVFQFIAIAGQALFLATAITKLWQGQLFSHTIPWVLGFFACFLSREIINFGRSKALDKLAYQLATKLRGDMLDKFFRLGPVAIANLGSGSAATTVITGIDQVENYIKLVLSKVLNMMIIPMLILIPVYFLDWQSGIVLTLTFPFAIIFMILLGYAAQGRAERQYKTFQYLSNHFLDSLRGISTLKYFGLSKDYSNSIYKTSEDFRKETMGALRIAMLSTFALDFFASLSVAVVALFLGLRLMSGDILLFPALAALILAPEYFLPLRDFASDYHATLNGKNALAAVNEVLSTEENTLSVLTEKVTWSANSQLQLTELGKIYDTGRGISNVNLSVNGFKNIAIIGNSGSGKSTLLSMLAGFLKPTAGEIKLNEQSLTSLTDENYRQSVQFIPQKTYIFAGTFRENLAFYEPDSTDDEIKAAAKLAGLESLIDEIGLDGQIGASGRTISGGQAQRVALARAFLSHTRNILFLDEPTAHLDIETELEIKANILPLLENKLVFIATHRLHWLSSMDLVIVLNEGQVAGIGTPEQLLSENTYYQKLLSQMRGVDDDKNLLDNETSKSVKDQEEKVSERSNFSSVNDKSTDSSVSQASSDNGGQK
>NC_020450.1|WP_015426045.1|686025_687747_+|thiol-reductant-ABC-exporter-subunit-CydC
MKLKNILFGNDWISPFLKKNRSGFILSIFLGTITISMAGLLMFSSGYVISKSATKPENILMIYVPVLFVRIFGIGRPVMHYVERLTSHNWILKITSLLRKKLYLRLEKTAVTLADRYRLGDLLGVLNEDIGNLQDLFLRTLFPVLIAGSLSIALIIAGGFFSLWFALGLALFLGFLIVILPLISLKFTVKLDEELKIYRNQLFSHLTDDILGLQDWVLSGRKEDFLTAYRGSELSARKIQAKLLAFGRRRNLFLQIVYGALVIYLMIWSSGALRLGDAPNYIAAVSLAAFPLFDAFSPLSDAVVETQRYGDSINRLNDLPDQDEEVRTEEIVSTDLVINNLQFSFEENKKIFDNFNLEVKQGEHIALLGRSGVGKSTLAGLIRGDLVPQSGSIQFSGVEPSKAKNVEEKIGVINQSPYLFATSLRSNLTLAKLNASDAEIWEALELVGLRKMVESLPQKLLTPVDEAGERFSGGERQRLALARVLLSDVDVVILDEPTVSLDPITENQLLSLFFERLRDKSIIFITHHLLGVHHMDRVLFLENGSIKFDGKPASLLENNPTFKELYQLDLGNE
>NC_020450.1|WP_003129644.1|688039_688915_+|MarR-family-transcriptional-regulator
MSEQTNNLLNLFSKLLHNPNILFALRADGISKQMKNRGNRNGAQGLLVELWNKDGLTNAEIAELLDIKPSSVTAQVKQLEEAEMVIRKQDENDKRVSRIFLTDKGREAQETRDTMHNDISETIFGNLTDEEQEQLAFLMEKLVENNDARNDQDFQRMAQFFGNPFMENMMNAHDRHAFGNHMRREMQNWQREMRRSSQEMKRGQNRMRRDERSQAPFGEDWKAFGKQLKDSFRNNFGGRDQADFNEHWDHFSDEMKNRFGDFDGNRRPDFDSKPKTDKNKEPKKPENWDDF
>NC_020450.1|WP_015426047.1|688940_689396_+|flavodoxin
MRTLIAYAGKTGNTAKCARKLAIHLNQVTLVDLNAEVVNPKDFDAVIVASPVYSHKFERSVGSFLKKYQEILQTKPFAAFVTMVEYDSFTKVIKKEIANFGGEVNNLTPFNWHDKIIAKSMIKLESKKHPIEFLPEAEKQFVAQLNKVEWI
>NC_020450.1|WP_015426048.1|689422_690097_+|hypothetical-protein
MSKETKARTINPQLAAFQEELLKNYDKANLSAKKGQTLFVGSSLMEIFPIEKWEEAGEVTFSHYIYNRAVRATTTSFLLEHIESQIFNLEPSKIFINIGTNDIGFEIPEEEFLNNYDQILSQIESKLPQTQVYVMRYYPINTVDFGQDSDEKTLFETRSNEKFQKASDKIKKLADNHHFHFIDVNDGLSDENGNLKKELTFDGAHLNPAGYQLVLENLKVYLEE
>NC_020450.1|WP_042230706.1|690198_691953_+|multidrug-efflux-ABC-transporter-LmrA
MANRIEGKAVDKTSIKHFVKLIRAAKPRYLFFIIGILAGIVGTLIQLQVPKMVQPLVNSFGHGVNGGKVALVIALYIGSAAVSAIAAIVLGIFGESVVKNLRTRVWDKMIHLPVKYFDEVKTGEMSSRLANDTTQVKNLIANSIPQAFTSILLLVGSIVFMLQMQWRLTLAMIIAVPVVMLIMFPIMTFGQKIGRTRQDSLANFQGIASESLSEIRLVKSSNAEKQASKKAENDVNALYKIGVKEAIFDGLMSPVMMLSMMLMIFGLLAYGIYLISTGVMSLGTLLGMMMYLMNLIGAVPTVATFFTELAKASGSTGRLTELLDEEQEVLHQGESLDLEGKTLSARHVDFAYDDSEQILRDISFEAQPNSIIAFAGPSGGGKSTIFSLLERFYQPTAGEITIDGQPIDNISLENWRSQIGFVSQDSAIMAGTIRENLTYGLEGDYTDDDLWQVLDLAFARSFVENMPDQLNTEVGERGVKISGGQRQRLAIARAFLRNPKILMLDEATASLDSESESMVQKALDSLMKGRTTLVIAHRLSTIVDADKIYFIEKGQITGSGKHNELVAAHPLYAKYVSEQLTVGQ
>NC_020450.1|WP_015426050.1|691971_692583_-|DUF1211-domain-containing-protein
MVSKGRLAGFIDAIIAVIMTIMLLEFELPKTGGILDFLKDNLVYLIAYLLSFIYVTTSWFNQQYMLSQAEKITRRIYHSCMIWVLSLSMLPVLSAWAGRTMDFFHDFGIHSPKAPALLFIVMIYIWGFAYSYMTDCFIADNPKEKAELIAQMEVYHYLRNPFWKIGMVISFIITFFYPPFVFIYTAGEMIIATIRSQNKKSST
>NC_020450.1|WP_010905527.1|692653_693298_-|DedA-family-protein
MQEIIIQVMNQFGYFGVAFLIMIENIFPPIPSEVILTFGGFMTTYSELGIIGMIIAATIGSVLGALILYFVGRLLSVERLEKLVSGRLGKVLRLKPEDITKAEKWFLKRGYATIFFCRFIPLIRSLISIPAGSAKMKLPSFLILTTLGTLIWNIVLVCLGAALGDNWEMIAGILDSYSSVVVVILGIIFILAILIFVKKRFFPKNKNYSSDTEK
>NC_020450.1|WP_015426051.1|693504_695499_-|ABC-transporter-ATP-binding-protein/permease
MAVLELKNIRKSYFLGKEEFPVLKGINLEFERGDFVSLLGESGGGKSTLMNIIGGLDRKYEGDVIVDGLAQKTKKEKDMDAYRRDTIGFIFQSFNLVSYLSVLDNILISLKMTSLSDKERHERAIELTKQVGLYEHRKKNPSQLSGGQKQRVAIARALASDPEIILADEPTGALDSQNTKEVLALLRQIAQSGKTVIVVTHSQEVADYGTRIIRLADGQITGDERLKEPYPVESHQRMNSKALSYRDTFRTAFKHFTHSWKINLLIAIGTAIGLFSVIFFLGLGNGATKYMNDTITSSVNPNVVTIFKRTTTDNKLGNEQALQQTQQELGNAATNLDSTHLSKLKKVDNVKKVEPTYSISGLGTLTASDKSKSGLMTLDTWTQSNINDDYVAGSKPADGEIAIYASDAKELNKDYKSLVGKKITLKIPAKTAAGTSVEVTKEFTVSGILKNPQGPASSSSSLIATYNTVKAALESANADTDATYAVVTVNKVDNVKSTTSDIQDLKIDGTKAFVTYSVTSFLDIITNITNIVSYVLAAIAGISLIVSIFMIVVTTYMSVAERTKEIGVIRALGGRKKDISRLFTAESLILGLSSAAIAIGFAYLGQFLINKALSSFLDGASIVQISGGHIIFAIIVAVLIALLASLAPSGRAARLNTIEALASE
>NC_020450.1|WP_003129656.1|695605_695824_-|DNA-binding-protein
MNGYQQQYTCIKCGNHNFEEDQLQATGGNFSKIFDVQNKKFITISCSQCGYTELYKAQTSTGMNILDFLLNG

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Crispr_ID: NC_020450_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_020450_2

1193515-1193630

Orphan

Consensus_repeat	Method
AAATGCGATTGAATAGTGAGCATTTTAGTTGTTGATAAAAGAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_020450_2

>merge|NC_020450|2|1193515-1193630|CRISPRCasFinder
AAATGCGATTGAATAGTGAGCATTTTAGTTGTTGATAAAAGAACCGTCAGCGCAGCTGACAATTCTGTCAGTAAATGCGATTGAATAGTGAGCATTTTAGTTGTAGATAAAAGAAC

>NC_020450|2|2|1193515-1193630|CRISPRCasFinder
AAATGCGATTGAATAGTGAGCATTTTAGTTGTTGATAAAAGAAC	CGTCAGCGCAGCTGACAATTCTGTCAGT
AAATGCGATTGAATAGTGAGCATTTTAGTTGTAGATAAAAGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_020450.1\|WP_015426403.1\|1196603_1198316_+\|dihydroxy-acid-dehydratase	unknown	unknown	gnl\|CDD\|234861
NC_020450.1\|WP_015426404.1\|1198326_1200054_+\|acetolactate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|180919
NC_020450.1\|WP_042230334.1\|1183770_1184562_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|372616
NC_020450.1\|WP_015426396.1\|1188717_1189527_+\|histidinol-phosphatase	unknown	unknown	gnl\|CDD\|273837
NC_020450.1\|WP_015426408.1\|1203012_1203723_+\|acetolactate-decarboxylase	unknown	unknown	gnl\|CDD\|273524
NC_020450.1\|WP_015426407.1\|1201646_1202897_+\|threonine-ammonia-lyase-IlvA	unknown	unknown	gnl\|CDD\|236318
NC_020450.1\|WP_015426392.1\|1185984_1186593_+\|imidazole-glycerol-phosphate-synthase-subunit-HisH	unknown	unknown	gnl\|CDD\|237288
NC_020450.1\|WP_015426395.1\|1188078_1188717_+\|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE	unknown	unknown	gnl\|CDD\|235067
NC_020450.1\|WP_015426398.1\|1190924_1192466_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|234864
NC_020450.1\|WP_015426391.1\|1185157_1185946_+\|aminoglycoside-3'-phosphotransferase	unknown	unknown	gnl\|CDD\|225771
NC_020450.1\|WP_015426394.1\|1187302_1188082_+\|imidazole-glycerol-phosphate-synthase-subunit-HisF	unknown	unknown	gnl\|CDD\|234996
NC_020450.1\|WP_015426406.1\|1200568_1201591_+\|ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235491
NC_020450.1\|WP_015426401.1\|1195113_1195689_+\|3-isopropylmalate-dehydratase-small-subunit	unknown	unknown	gnl\|CDD\|179314
NC_020450.1\|WP_015426402.1\|1195702_1196482_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_020450.1\|WP_015426390.1\|1184558_1185161_+\|imidazoleglycerol-phosphate-dehydratase-HisB	unknown	unknown	gnl\|CDD\|153419
NC_020450.1\|WP_015426405.1\|1200046_1200523_+\|acetolactate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|183365
NC_020450.1\|WP_015426397.1\|1189540_1190500_-\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|234663
NC_020450.1\|WP_015426409.1\|1203763_1204144_+\|RidA-family-protein	unknown	unknown	gnl\|CDD\|129116
NC_020450.1\|WP_015426393.1\|1186593_1187313_+\|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]imidazole-4--carboxamide-isomerase	unknown	unknown	gnl\|CDD\|179108
NC_020450.1\|WP_015426400.1\|1193711_1195094_+\|3-isopropylmalate-dehydratase-large-subunit	unknown	unknown	gnl\|CDD\|235490

Protein	Function_ID	Function_description	E-value
NC_020450.1\|WP_015426403.1\|1196603_1198316_+\|dihydroxy-acid-dehydratase	gnl\|CDD\|234861	PRK00911, PRK00911, dihydroxy-acid dehydratase; Provisional.	0
NC_020450.1\|WP_015426404.1\|1198326_1200054_+\|acetolactate-synthase-large-subunit	gnl\|CDD\|180919	PRK07282, PRK07282, acetolactate synthase large subunit.	0
NC_020450.1\|WP_042230334.1\|1183770_1184562_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	6.11219e-13
NC_020450.1\|WP_015426396.1\|1188717_1189527_+\|histidinol-phosphatase	gnl\|CDD\|273837	TIGR01856, Probable_histidinol-phosphatase, histidinol phosphate phosphatase, HisJ family. This model represents the histidinol phosphate phosphatase HisJ of Bacillus subtilis, and related proteins from a number of species within a larger family of phosphatases in the PHP hydrolase family. HisJ catalyzes the penultimate step of histidine biosynthesis but shows no homology to the functionally equivalent sequence in E. coli, a domain of the bifunctional HisB protein. Note, however, that many species have two members and that Clostridium perfringens, predicted not to make histidine, has five members of this family; this family is designated subfamily rather than equivalog to indicate that members may not all act as HisJ.	9.25039e-101
NC_020450.1\|WP_015426408.1\|1203012_1203723_+\|acetolactate-decarboxylase	gnl\|CDD\|273524	TIGR01252, Alpha-acetolactate_decarboxylase, alpha-acetolactate decarboxylase. Puruvate can be fermented to 2,3-butanediol. It is first converted to alpha-acetolactate by alpha-acetolactate synthase, then decarboxylated to acetoin by this enzyme. Acetoin can be reduced in some species to 2,3-butanediol by acetoin reductase. [Energy metabolism, Fermentation].	2.76141e-124
NC_020450.1\|WP_015426407.1\|1201646_1202897_+\|threonine-ammonia-lyase-IlvA	gnl\|CDD\|236318	PRK08639, PRK08639, threonine dehydratase; Validated.	0
NC_020450.1\|WP_015426392.1\|1185984_1186593_+\|imidazole-glycerol-phosphate-synthase-subunit-HisH	gnl\|CDD\|237288	PRK13141, hisH, imidazole glycerol phosphate synthase subunit HisH; Provisional.	6.07335e-113
NC_020450.1\|WP_015426395.1\|1188078_1188717_+\|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE	gnl\|CDD\|235067	PRK02759, PRK02759, bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE.	3.96222e-121
NC_020450.1\|WP_015426398.1\|1190924_1192466_+\|2-isopropylmalate-synthase	gnl\|CDD\|234864	PRK00915, PRK00915, 2-isopropylmalate synthase; Validated.	0
NC_020450.1\|WP_015426391.1\|1185157_1185946_+\|aminoglycoside-3'-phosphotransferase	gnl\|CDD\|225771	COG3231, Aph, Aminoglycoside phosphotransferase [Translation, ribosomal structure and biogenesis].	1.32621e-126
NC_020450.1\|WP_015426394.1\|1187302_1188082_+\|imidazole-glycerol-phosphate-synthase-subunit-HisF	gnl\|CDD\|234996	PRK02083, PRK02083, imidazole glycerol phosphate synthase subunit HisF; Provisional.	3.51651e-158
NC_020450.1\|WP_015426406.1\|1200568_1201591_+\|ketol-acid-reductoisomerase	gnl\|CDD\|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NC_020450.1\|WP_015426401.1\|1195113_1195689_+\|3-isopropylmalate-dehydratase-small-subunit	gnl\|CDD\|179314	PRK01641, leuD, 3-isopropylmalate dehydratase small subunit.	1.59808e-121
NC_020450.1\|WP_015426402.1\|1195702_1196482_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	3.82285e-107
NC_020450.1\|WP_015426390.1\|1184558_1185161_+\|imidazoleglycerol-phosphate-dehydratase-HisB	gnl\|CDD\|153419	cd07914, IGPD, Imidazoleglycerol-phosphate dehydratase. Imidazoleglycerol-phosphate dehydratase (IGPD; EC 4.2.1.19) catalyzes the dehydration of imidazole glycerol phosphate to imidazole acetol phosphate, the sixth step of histidine biosynthesis in plants and microorganisms where the histidine is synthesized de novo. There is an internal repeat in the protein domain that is related by pseudo-dyad symmetry, perhaps as a result of an ancient gene duplication. The apo-form of IGPD exists as a catalytically inactive trimer which, in the presence of specific divalent metal cations such as manganese (Mn2+), cobalt (Co2+), cadmium (Cd2+), nickel (Ni2+), iron (Fe2+) and zinc (Zn2+), assembles to form a biologically active high molecular weight metalloenzyme; a 24-mer with 4-3-2 symmetry. Each 24-mer has 24 active sites, and contains around 1.5 metal ions per monomer, each monomer contributing residues to three separate active sites. IGPD enzymes are monofunctional in fungi, plants, archaea and some eubacteria while they are encoded as bifunctional enzymes in other eubacteria, such that the enzyme is fused to histidinol-phosphate phosphatase, the penultimate enzyme of the histidine biosynthesis pathway. The histidine biosynthesis pathway is a potential target for development of herbicides, and IGPD is a target for the triazole phosphonate herbicides.	9.46012e-115
NC_020450.1\|WP_015426405.1\|1200046_1200523_+\|acetolactate-synthase-small-subunit	gnl\|CDD\|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	2.45118e-62
NC_020450.1\|WP_015426397.1\|1189540_1190500_-\|rhodanese-related-sulfurtransferase	gnl\|CDD\|234663	PRK00142, PRK00142, rhodanese-related sulfurtransferase.	0
NC_020450.1\|WP_015426409.1\|1203763_1204144_+\|RidA-family-protein	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	4.61097e-66
NC_020450.1\|WP_015426393.1\|1186593_1187313_+\|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]imidazole-4--carboxamide-isomerase	gnl\|CDD\|179108	PRK00748, PRK00748, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Validated.	1.58245e-120
NC_020450.1\|WP_015426400.1\|1193711_1195094_+\|3-isopropylmalate-dehydratase-large-subunit	gnl\|CDD\|235490	PRK05478, PRK05478, 3-isopropylmalate dehydratase large subunit.	0

>NC_020450.1|WP_015426398.1|1190924_1192466_+|2-isopropylmalate-synthase
MRKIEFFDTSLRDGEQTPGVSFSISEKVTIAKQLEKWGISVIEAGFPAASPDSFEAVKQIADSLNDTAVTALARCVISDIDKAVEAIKGAKHPQIHVFIATSPIHMKYKLKISPEEVLKNIDKCVRYARERVEVVEFSPEDATRTELNFLLEAVQTAINAGATYINIPDTVGYTTPEEYGKIFKFLIDNIKSDREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGERAGNAALEEIAVALHIRKDFYQAQSPLKLSETVATAELISQFSGISIPKNKAIVGANAFAHESGIHQDGVLKNAETYEIITPELVGIKHNSLPLGKLSGRHAFSEKLTELNIAYDDESLAILFEKFKKLADKKKEITDADIHALFTGETVKNLAGFILDNVQIDGHKALVQLKNQEEEIYVSQGEGSGSVDAIFKAIDKVFNHQLKLISYSVDAVTDGIDAQATTLVSVENLSTGTIFNAKGVDYDVLKGSAIAYMNANVLVQKENLQGKVEQISAHDGI
>NC_020450.1|WP_015426397.1|1189540_1190500_-|rhodanese-related-sulfurtransferase
MTQDYRVLLYYQYVPIEDGETFAQKHLADCKELGLKGRILVADEGINGTVSGTIEQTNAYMELMKNDPRFSSIIFKIDEAEQNAFKKMHVRYRPELVNLSLEDDVNPLELTGAYLDPKEFREAMLDENTVVIDARNDYEFDLGHFRGAIRPEIRSFRELPQWIRDNKEQFMEKRVLTYCTGGIRCEKFSGWLVREGFKDVGQLHGGIATYGKDPEVQGDLWDGQMYVFDSRIAVPINQKEHVIVGRDWFDGSPCERYINCGNPECNRQMLASEENEAKYLGACSHECRVHPNNRYIKAHQLSNQEVQERLALLEKDLAS
>NC_020450.1|WP_015426396.1|1188717_1189527_+|histidinol-phosphatase
MKKLDYHFHSHFSADSEELPRNHVIEAIAHGLKEICFTEHRDFYFPGMDFSLNLPEYFQEINRLQAEFKDKIKIKIGLEMGIDLRFKSEINKFIDSAPFDFVIASVHEIGDIEVYDGTEFYLQKTKEEAQREYLLACLDTVQNFVNYNSFGHLDYVARYGPYTDKSIKFAENREILFEILRALASKEKALEINTRLFDNPKTEQFYSDLLINFKKLGGKFITLGTDSHIAKRDWLSIHKARTLIKKAGFHELATFSGMKIDKNKKSIKE
>NC_020450.1|WP_015426395.1|1188078_1188717_+|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE
MKPDFHKQKLIPVIVQDYQTNQVLMLAYTNEVAFEKMLETGETWFWSRSRQKLWHKGEESGHFQKIKGMRLDCDQDTLLVFVEQIGNACHTGAYSCFYDELIPFDDSDIFRELEKQIIDRKLHPVEKSYTNYLLEEGIDKVLKKVGEEASEVIIASKNSDKGELLGEIDDLLYHLFVLMNQQGISLEEVRQKAKERHQLEGNKKEFHTRTAD
>NC_020450.1|WP_015426394.1|1187302_1188082_+|imidazole-glycerol-phosphate-synthase-subunit-HisF
MLTKRIIPCLDIKNGKVVKGINFVGLREIGDPVELAKIYEEQCADEIVFLDITASFEEREIIGELIGRAARELSIPLTVGGGIRSIDDFRRILARGADKVSVNSAAIENPELIRQAANEFGVQCVVVAIDAKKRADHRGYDVYIKGGREIAGLDLVDWAKKCERLGAGEILLTSMDKDGTKTGYDLEMLNTVCTAVNIPVVASGGCGKISDIVEVFQNTRSDAALVASLFHYGEATVDEVKDELIKNNISARIIKKEIL
>NC_020450.1|WP_015426393.1|1186593_1187313_+|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]imidazole-4--carboxamide-isomerase
MKIIPAIDLQNGKAVRLYKGDYDKKTVYSKNPLEIAQKFERMGATDLHLVDLDGAKIGQTRNLELVRKIKDETRLKIEIGGGIRDFDTVRLYLEQIGVERVILGTAAVENPDFLKELLIKYGPSKIVVGVDIREGFVSTSGWLEKTSLPYLSFLKKLERIGVKTTIITDISKDGTLTGPNFKLYDEISKECSLNVIISGGVKDSSDIQRATRSDFYGIIVGKAYYEGKINLEKEFRNAN
>NC_020450.1|WP_015426392.1|1185984_1186593_+|imidazole-glycerol-phosphate-synthase-subunit-HisH
MKKIVIIDYNIGNLQSVQAAFLRLGQETVISRDLEEIRKADALILPGVGAFPTAMNNLKKFNLIELIQERAAAGIPILGICLGMQVLFEKGYEIEERQGLGLLKGEVIPIKTNEKIPHMGWNQLNLAKTSPTTHYLSDNDEVYFVHSYQATCPDDELIAYTTYGEVKIPAIVGKNNVIGCQFHPEKSGEIGRKILKAFLEEI
>NC_020450.1|WP_015426391.1|1185157_1185946_+|aminoglycoside-3'-phosphotransferase
MTNLKELRINIEKFPEAIHNTLKDAKIYDSSSSPEAQVLFIDKKDGYYLKIASSKTLEREAEMTAYFQKKKLGLGYISYLSGQSQDFLLKKKIQGENYLAKKYLNNPKRLCDSLAENLRFLHEQNFEDCPILDHSERYLKKVEKNASIKHSNLDFVNNYNVRTTEEAYDYIENKKLLLKNDTLLHGDYCLPNIILDNWKFKGFIDLDCAGVGDRHIDLFWGAWTLNFNIGTDQYRDRFFDAYGRDRIDVDRLKLVGCCEVFG
>NC_020450.1|WP_015426390.1|1184558_1185161_+|imidazoleglycerol-phosphate-dehydratase-HisB
MTRISHITRNTKETQIELSINLDGTGQADISTGIGFLDHMLTLLTFHSDFDLKIIGHGDHETVGMDPHHLIEDVAIALGKCISEALGNKLGIRRYGSFTIPMDEALVTCDLDISGRPYLVFHADLSGNQKLGGYDTEMTEEFFRALAFNAGITLHLNENYGQNTHHIIEGMFKSTARALKQAVSIDEAKVGEIPSSKGVL
>NC_020450.1|WP_042230334.1|1183770_1184562_+|methyltransferase-domain-containing-protein
MDFKILNKKNSREKNMTKQENYYAEVFEKPWGRMFYDLLFPQLLPNLTKDSKILSFGSGFGRTETFLEEQGFEVTGYEPDVEKLEMMSDQTFRQLTGTFDDFAETVKNERYDVILIHNVLEYVLDRKVVLELLLSLLTDGGTLSIVKHSKYGSMIEMAAGRDNPQAALDVYENEAVASHNHGDILVYDDDWLTDFVANYKLKLQEKFGIRHFYGISQNVEIKETDNWYQPMLKLEQKVAKDQTLYPVARLHHLIFKKTKENLL
>NC_020450.1|WP_015426400.1|1193711_1195094_+|3-isopropylmalate-dehydratase-large-subunit
MSGKTIFDKLWDQHVIAGNEGEPQLLYIDLHVIHEVTSPQAFQGLREAGRRVRRKDLTYGTLDHNVPTQDIFNIQDLISKKQIDTFTKNVKEFDVPAETHGGKGQGIVHMVAPESGRTQPGKTIVCGDSHTATNGAFGAIAFGIGTSEVEHVLATQTIWQVKPKRMKIEFQGHPQKGIYSKDFILALIAKYGVDAGVGYAVEYSGDAISDLSMEERMTICNMSIEFGAKIGLMNPDEKTYDYVKGREHAPKNFDEAVSKWEKIVSDSDAQYDKILSLDVSQLKPMVTWGTNPGMGLEFGEKFPEINNDLNYERAYQYMDLKPGQTASDIDLGYIFIGSCTNARLGDLEEAAKIIGDRHIADGLTGIVVPGSRPVKEAAEAQGLDKIFKEAGFEWREPGCSACLGMNPDQIPEYVHCASTSNRNFEGRQGHNARTHLCSPAMAAAAAIAGKFVDVRTLVTD
>NC_020450.1|WP_015426401.1|1195113_1195689_+|3-isopropylmalate-dehydratase-small-subunit
MEKFTIYKGTSVPVMNDNIDTDQIIPKQFLKAIDKKGFGKNLFYEWRYLKDYDENPDFILNAPKYKKASLLISGDNFGSGSSREHAAWALSDYGFRAIIAGSYSDIFYNNALKNGLLPIKQPREVLNQLTKLSSQEEITIDLPHQLIITSLGDFHFEIDPIWKNKLINGLDDIGITLQYEEAISAYEQKNQ
>NC_020450.1|WP_015426402.1|1195702_1196482_+|ABC-transporter-ATP-binding-protein
MTIINLKNVNLTRNKKEILKDITWKVNPGENWVILGLNGSGKSSLLKLILAEEWKTSGEITVLNTQFGNGEIPKLRKRISVVGSFIAERFQPNIKAENLVYTGKFNSSMLYKPYTDQELDEARQLLRQMGAKSLIGRNYASLSQGEKQVLLIARSLILKPELLILDEATNGLDLFAKEKLLKQLQQINQLKNAPTLIYISHHPDEITDIFTHLLLLREGKVIQSGKKENLLNEKILTDFYQEKVEVHHFEQKYFVIPAN
>NC_020450.1|WP_015426403.1|1196603_1198316_+|dihydroxy-acid-dehydratase
MEFKYNGKVESVELNKYSKTLTQDPTQPATQAMYYGIGFKDEDFKKAQVGIVSMDWDGNPCNMHLGTLGSKIKSSVNQTDGLIGLQFHTIGVSDGIANGKLGMRYSLVSREVIADSIETNAGAEYYDAIVAIPGCDKNMPGSIIGMARLNRPSIMVYGGTIEHGEYKGEKLNIVSAFEALGQKITGNISDEDYHGVICNAIPGQGACGGMYTANTLAAAIETLGMSLPYSSSNPAVSQEKQEECDEIGLAIKNLLEKDIKPSDIMTKEAFENAITIVMVLGGSTNAVLHIIAMANAIGVEITQDDFQRISDITPVLGDFKPSGKYMMEDLHKIGGLPAVLKYLLKEGKLHGDCLTVTGKTLAENVETALDLDFDSQDIMRPLKNPIKATGHLQILYGNLAQGGSVAKISGKEGEFFKGTARVFDGEQHFIDGIESGRLHAGDVAVIRNIGPVGGPGMPEMLKPTSALIGAGLGKSCALITDGRFSGGTHGFVVGHIVPEAVEGGLIGLVEDNDIIEIDAVNNSISLKVSDEEIAKRRANYQKPAPKATRGVLAKFAKLTRPASEGCVTDL
>NC_020450.1|WP_015426404.1|1198326_1200054_+|acetolactate-synthase-large-subunit
MKKIKLEKPTSGSQLVLQTLKELGVEIIFGYPGGAMLPLYDAIHNFEGIQHILARHEQGATHEAEGYAKSSGKVGVVVVTSGPGATNAVTGIADAYLDSVPLLVFTGQVGRQSIGKDAFQEADTVGITAPITKYNYQIRETADIPRIVTEAYYLARTGRPGPVEIDLPKDVSTLEVTEINDPSLNLPHYHESEKATDEQLQELLTELSVSKKPVVIAGGGINYSGSVDIFRAFVEKYQIPVVSTLLGLGTLPISHELQLGMAGMHGSYAANMALVEADYIINLGSRFDDRVVSNPAKFAKNAVVAHIDIDAAELGKIVKTDIPILSDLKVALSRLLQLNKVKTDFNDWIKTVTKNREKAPFTYEPQNHDIRPQETIKLIGEYTQGDAIIVTDVGQHQMWVAQYYPYKNARQLITSGGMGTMGFGIPAAIGAKLAQPNKNVIVFVGDGGFQMTNQELALLNGYGIAIKVVLINNHSLGMVRQWQESFYEERRSQSVFDVEPNFQLLAEAYGIKHVKLDNPKTLADDLKIITEDEPMLIEVLISKSEHVLPMIPAGLHNDEMIGLHFTDENEEVDNA
>NC_020450.1|WP_015426405.1|1200046_1200523_+|acetolactate-synthase-small-subunit
MRRMIIAKLHNITGIMNRFTAVLNRRQVNILSITAGVTESQDLTHTTFVIEVDHLDEVEQIIKQLNRLIDVIEVADITDLPHVEREVVLIKVSAPPTIRAEIFTMIEPFRVNVVDVNLENVTIQLTGDSAKIEALIDVVSPYGILNMARTGSAGFERG
>NC_020450.1|WP_015426406.1|1200568_1201591_+|ketol-acid-reductoisomerase
MAVTMYYEDDVEVSALAGKQIAVIGYGSQGHAHAQNLRDSGHNVIIGVRHGKSFDKAKEDGFETFEVGEAVAKADVIMVLAPDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIKVPEDVDVFMVAPKAPGHLVRRTYTEGFGTPALFVSHQNASGHAREIAMDWAKGIGCARVGIIETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMYEGGFTKMRQSISNTAEFGDYVTGPRIITDEVKKNMKLVLADIQSGKFAQDFVDDFKAGRPKLTAYREAAKNLEIEKIGAELRQAMPFTQSGDDDAFKIYQ
>NC_020450.1|WP_015426407.1|1201646_1202897_+|threonine-ammonia-lyase-IlvA
MISAKEVEDAYDLLKAVVTKTPLQLDPYLSNKYQANIYLKEENLQKVRSFKLRGAYYSISKLSDEQRSKGVVCASAGNHAQGVAFAANQLNISATIFMPVTTPNQKISQVKFFGESHVTIRLIGDTFDESARAAKAFSQDNDKPFIDPFDDENVIAGQGTVALEIFAQAKKQGISLDKIFVQIGGGGLIAGITAYSKERYPQTEIIGVEAKGATSMKAAYSAGQPVTLEHIDKFADGIAVATVGQKTYQLINDKVKQLLAVDEGLISQTILELYSKLGIVAEPAGATSVAALELIKDEIKGKNIVCIISGGNNDISRMQEIEERALVYEGLKHYFVINFPQRPGALRTFVSDILGPNDDITRFEYIKRADKGKGPCLVGILLSDASDYDSLINRIERFDNRYVNLHGNDSLYELLV
>NC_020450.1|WP_015426408.1|1203012_1203723_+|acetolactate-decarboxylase
MTEITQLFQYNTLGALMAGLYEGTMTIGELLKHGDLGIGTLDSVDGELIVLDGKAYQAKGDKTIVELTDDIKVPYAAVVPHQAEVVFKQKFTASDKELEDRIESYFDGQNLFRSIKITGEFPKMHVRMIPRAKSGTRFVEVSQNQPEYTEENVKGTIVGIWTPEMFHGVSVAGYHLHFISEDFTFGGHVLDFIIDNGTVEIGAIDQLNQSFPIQDRKFLFADLDIEALKKDIDVAE
>NC_020450.1|WP_015426409.1|1203763_1204144_+|RidA-family-protein
MKIIATSDAPAAIGPYVQGKIVNGLLYASGQIPLNPLNGEIVGDSIETQTEQVMKNISAILKEAHSDFDLVIKTTCFLKNIEDFSRFNAIYSKFFDKEFPARSAVGVAGLPKNVLIEIEVIAEVKS

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Crispr_ID: NC_020450_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_020450_3

1805689-1805783

Orphan

Consensus_repeat	Method
GATTTGCTGACAGTTCTGTCAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_020450_3

>merge|NC_020450|3|1805689-1805783|CRISPRCasFinder
GATTTGCTGACAGTTCTGTCAGTTCAACGCGACCAACGGAAGATGTTGAATCGGCAGATTGAGGAACTGGCAGCTTTGCTGACAGTTCTGTCAGT

>NC_020450|3|3|1805689-1805783|CRISPRCasFinder
GATTTGCTGACAGTTCTGTCAGT	TCAACGCGACCAACGGAAGATGTTGAATCGGCAGATTGAGGAACTGGCA
GCTTTGCTGACAGTTCTGTCAGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_020450.1\|WP_015426871.1\|1815824_1816691_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226354
NC_020450.1\|WP_015426869.1\|1813132_1814359_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270373
NC_020450.1\|WP_021722126.1\|1795687_1797121_-\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|236580
NC_020450.1\|WP_039115764.1\|1817851_1818796_+\|hypothetical-protein	unknown	unknown	unknown
NC_020450.1\|WP_042230779.1\|1814475_1815819_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_020450.1\|WP_015426855.1\|1791014_1791848_-\|Rgg/GadR/MutR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273772
NC_020450.1\|WP_015426863.1\|1802952_1805208_-\|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl\|CDD\|237517
NC_020450.1\|WP_015426865.1\|1806982_1808557_-\|alpha-amylase	unknown	unknown	gnl\|CDD\|200455
NC_020450.1\|WP_015426856.1\|1791884_1792625_-\|demethylmenaquinone-methyltransferase	unknown	unknown	gnl\|CDD\|334435
NC_020450.1\|WP_015426860.1\|1797625_1799368_-\|1-deoxy-D-xylulose-5-phosphate-synthase	unknown	unknown	gnl\|CDD\|237053
NC_020450.1\|WP_042230778.1\|1809178_1810774_-\|alpha-glucosidase	unknown	unknown	gnl\|CDD\|200472
NC_020450.1\|WP_015426859.1\|1797242_1797509_-\|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl\|CDD\|223830
NC_020450.1\|WP_015426862.1\|1801825_1802800_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_020450.1\|WP_021470128.1\|1808546_1809152_-\|sugar-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100047
NC_020450.1\|WP_015426868.1\|1811010_1812765_-\|alpha-glycosidase	unknown	unknown	gnl\|CDD\|200477
NC_020450.1\|WP_042230545.1\|1799515_1800886_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_020450.1\|WP_015426872.1\|1816850_1817846_+\|hypothetical-protein	unknown	unknown	unknown
NC_020450.1\|WP_015426874.1\|1818797_1819355_+\|hypothetical-protein	unknown	unknown	unknown
NC_020450.1\|WP_015426857.1\|1792722_1795428_-\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
NC_020450.1\|WP_003130364.1\|1800979_1801657_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NC_020450.1\|WP_015426871.1\|1815824_1816691_+\|sugar-ABC-transporter-permease	gnl\|CDD\|226354	COG3833, MalG, ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism].	8.20065e-99
NC_020450.1\|WP_015426869.1\|1813132_1814359_+\|extracellular-solute-binding-protein	gnl\|CDD\|270373	cd13655, PBP2_oligosaccharide_1, The periplasmic binding component of ABC tansport system specific for an unknown oligosaccharide; possess the type 2 periplasmic binidng fold. This group represents an uncharacterized periplasmic-binding protein of an ATP-binding cassette transporter predicted to be involved in uptake of an unknown oligosaccharide molecule. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.83165e-133
NC_020450.1\|WP_021722126.1\|1795687_1797121_-\|6-phospho-beta-glucosidase	gnl\|CDD\|236580	PRK09593, arb, 6-phospho-beta-glucosidase; Reviewed.	0
NC_020450.1\|WP_042230779.1\|1814475_1815819_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.01646e-57
NC_020450.1\|WP_015426855.1\|1791014_1791848_-\|Rgg/GadR/MutR-family-transcriptional-regulator	gnl\|CDD\|273772	TIGR01716, HTH-type_transcriptional_regulator_rgg, transcriptional activator, Rgg/GadR/MutR family, C-terminal domain. This model describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (pfam01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis. [Regulatory functions, DNA interactions].	9.45359e-58
NC_020450.1\|WP_015426863.1\|1802952_1805208_-\|glycoside-hydrolase-family-65-protein	gnl\|CDD\|237517	PRK13807, PRK13807, maltose phosphorylase; Provisional.	0
NC_020450.1\|WP_015426865.1\|1806982_1808557_-\|alpha-amylase	gnl\|CDD\|200455	cd11316, AmyAc_bac2_AmyA, Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase). AmyA (EC 3.2.1.1) catalyzes the hydrolysis of alpha-(1,4) glycosidic linkages of glycogen, starch, related polysaccharides, and some oligosaccharides. This group includes Chloroflexi, Dictyoglomi, and Fusobacteria. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_020450.1\|WP_015426856.1\|1791884_1792625_-\|demethylmenaquinone-methyltransferase	gnl\|CDD\|334435	pfam01209, Ubie_methyltran, ubiE/COQ5 methyltransferase family.	2.40957e-143
NC_020450.1\|WP_015426860.1\|1797625_1799368_-\|1-deoxy-D-xylulose-5-phosphate-synthase	gnl\|CDD\|237053	PRK12315, PRK12315, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional.	0
NC_020450.1\|WP_042230778.1\|1809178_1810774_-\|alpha-glucosidase	gnl\|CDD\|200472	cd11333, AmyAc_SI_OligoGlu_DGase, Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins. The sucrose isomerases (SIs) Isomaltulose synthase (EC 5.4.99.11) and Trehalose synthase (EC 5.4.99.16) catalyze the isomerization of sucrose and maltose to produce isomaltulose and trehalulose, respectively. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomaltooligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. Dextran glucosidase (DGase, EC 3.2.1.70) hydrolyzes alpha-1,6-glucosidic linkages at the non-reducing end of panose, isomaltooligosaccharides and dextran to produce alpha-glucose.The common reaction chemistry of the alpha-amylase family enzymes is based on a two-step acid catalytic mechanism that requires two critical carboxylates: one acting as a general acid/base (Glu) and the other as a nucleophile (Asp). Both hydrolysis and transglycosylation proceed via the nucleophilic substitution reaction between the anomeric carbon, C1 and a nucleophile. Both enzymes contain the three catalytic residues (Asp, Glu and Asp) common to the alpha-amylase family as well as two histidine residues which are predicted to be critical to binding the glucose residue adjacent to the scissile bond in the substrates. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_020450.1\|WP_015426859.1\|1797242_1797509_-\|membrane-protein-insertion-efficiency-factor-YidD	gnl\|CDD\|223830	COG0759, COG0759, Uncharacterized conserved protein [Function unknown].	5.94498e-41
NC_020450.1\|WP_015426862.1\|1801825_1802800_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.301e-97
NC_020450.1\|WP_021470128.1\|1808546_1809152_-\|sugar-O-acetyltransferase	gnl\|CDD\|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	5.86815e-90
NC_020450.1\|WP_015426868.1\|1811010_1812765_-\|alpha-glycosidase	gnl\|CDD\|200477	cd11338, AmyAc_CMD, Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins. Cyclomaltodextrinase (CDase; EC3.2.1.54), neopullulanase (NPase; EC 3.2.1.135), and maltogenic amylase (MA; EC 3.2.1.133) catalyze the hydrolysis of alpha-(1,4) glycosidic linkages on a number of substrates including cyclomaltodextrins (CDs), pullulan, and starch. These enzymes hydrolyze CDs and starch to maltose and pullulan to panose by cleavage of alpha-1,4 glycosidic bonds whereas alpha-amylases essentially lack activity on CDs and pullulan. They also catalyze transglycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules. Since these proteins are nearly indistinguishable from each other, they are referred to as cyclomaltodextrinases (CMDs). The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_020450.1\|WP_042230545.1\|1799515_1800886_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	6.72569e-49
NC_020450.1\|WP_015426857.1\|1792722_1795428_-\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	0
NC_020450.1\|WP_003130364.1\|1800979_1801657_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.03478e-70

>NC_020450.1|WP_015426863.1|1802952_1805208_-|glycoside-hydrolase-family-65-protein
MKQIKRIMGIDPWKITSNQIEKEDRRLQESLTSIGNGYMGMRGNFSETYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKAINALNFASVRVFIDDKEVDLAASHVTDFNLSLDMEKGVLTYTYVAYGVRVTAERFFSIAQQELAVFAFMFESLDGEIHQIRTASIIDANVRNEDSNYDEKFWTVKNLDNTATGSVIVTETIPNPFGVEQFTVAAKQSFAGDFTRVKQETRESSVLDVYEAKLIENAPLTFIKNVLVVTSRDVEPSNLTKVLSNLTLEISKKTYHEFYKEQEIAWKKRWEIADVQIDGSAEAQQGIRFNLFQLFSTYYGEDERLNIGPKGFTGEKYGGATYWDTEAYAVPLYLALSDEKVAKNLLKYRHNQLPQAQHNARQQGLKGALYPMVTFTGVECHNEWEITFEEIHRNGAMAYAIYNYSNYTGDETYLAHEGLEVLIEIARFWADRVHYSKRNDKYMIHGVTGPNEYENNINNNWYTNKLAAWVLTYTAESLAKYPRPDLIEGAEIAHWAEIVDKMYYPEDEELGIFVQHDGYLDKDLTPVAQLDPKNLPLNQNWSWDRVLRSPYIKQADVLQGIYFFGNQFSLAEKQRNFDFYEPLTVHESSLSPSIHAILAAELGMEDKAVEMYERTARLDLDNYNNDTEDGLHITSMTGSWLAIVHGFAQMKTWDGQLSFAPFLPQAWTGYAFHINYRGRLLKISVGQEVKLELLRGQALNLEIYGEKIELRDFYITKTK
>NC_020450.1|WP_015426862.1|1801825_1802800_-|LacI-family-DNA-binding-transcriptional-regulator
MAVTIKDVAKKAGVNASTVSRVIKDSSEISDKTKVKVRKAMHELGYRRNAAAQILASGKTNTIGVVFPPVADKASQPFFMKILTSINETARDYDVSIAIATGHSAKELKKQIELQYSEKRVDGFIVLYAGKNDEVRDYLLENKVPFVLVGTPAEGKNEITHVDNDNMLLGREAVRHLAQLKHQNISFVTDTKETEVFEERYQGFKDEAEKLGLNHDLLFMDANFSLRNETALVVMDDVLSLKVVECLRSQGLNVPEDVSLITYNNSIFGAMIHPYLTTFDIHIEQLGASAIKKILDLRDKKENLPEKSIIPFELIIRESTKARI
>NC_020450.1|WP_003130364.1|1800979_1801657_-|response-regulator-transcription-factor
MDSMIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEKNGFEVLKELREQNVDTPVLIMTAKESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLKRTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFDLVVYLMQNQNVILPKEQIFDRIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR
>NC_020450.1|WP_042230545.1|1799515_1800886_-|HAMP-domain-containing-histidine-kinase
MKKIIKKIKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQNRVFLEEAANNQLGTNNSQDSGFYGPNNSVIFYDSEGKNFMPSTGSNANISTNFGMSLLQKAMKFNEKHINTIQTVSVKNPYGDNLHYRYYTTSQFIITNSDGTVTPVYMQIFSNVDQIQDAMSRAMWVIVTTMITFWLLSIIISLYLANWTLRPILAAYEKQKEFVENASHELRTPLAILQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIRIEPEATTATYFENIFNSYEMLAENAGKKFSGHLKLDGTINLDQALIKQLLTILFDNALKYTGDEGEISVDVQKNGGFLVFAVADNGEGISDEDKKKIFDRFFRVDKARTRQKGGLGLGLSLAKQIVEAYNGKITVEDNKPKGTKFIVRIRVDSTISNPAKIFQKL
>NC_020450.1|WP_015426860.1|1797625_1799368_-|1-deoxy-D-xylulose-5-phosphate-synthase
MSVLEKIDSPADLKKVSNQELEELASEIRTAVLHKVSNIGGHVGPNLGVTELTIALHKVFNSPIDKFIWDVSHQTYPHKILTGRKNGFTDGHFHDITPYTSQRESEHDFFTVGHTSTSIANALGYAKARDLTNDKGNIVAVIGDGSLSGGLAMEALNNAGDFKGNLIILVNDNQMSIAENHGGLYRNLAELRATNGQAENNFFKTFGLDYKYLENGNDIESLIHLFEEVKDIDHPIVLHIHTEKGRGYQPALENKEAFHWHMPFDLETGQSKVFDSGKSYSSVMLDYMDKKVSEGLPLVAINAAIPGIFGLKQFAAKYPDRYIDAGIAEQFTITFGGAMAAAGARPIIFHNSTFVQRAYDQFWHDLAINEEPAIVIVKGGVISGSDETHQGSSAMTWISNIPNIKYLAPTSEEEFISILDWALEQHEEPVVIQMPEHGLESRPTVLTDYSTPSYQMTKSGEKVALLALGGLYSHGEKVAKVLAENGINATLINPLFINDLDQAFLENLVENHQVIATIEDGILDGGFGQKVASFLGKYDVKVLNFGAKREFNDSVPVTELYNRYHLTPELMVADILSLLK
>NC_020450.1|WP_015426859.1|1797242_1797509_-|membrane-protein-insertion-efficiency-factor-YidD
MKKVLVKAVHGYQRWISPALPPACRYYPTCSNYMIQAIEKHGPAKGLAMGTARILRCHPFCQPGYDLVPDHFSLRRNWAEPEKEKDSN
>NC_020450.1|WP_021722126.1|1795687_1797121_-|6-phospho-beta-glucosidase
MPFSKDFLWGGATAANQCEGGYNQGGRGLANVDLVPHGKDRFPIITGEMKHLEFDEDHFYPAKEAIDMYHHWKEDLALFAEMGFKTYRMSIAWTRIFPKGDEQEPNEEGLQFYEDIFRECQRLGIEPLVTITHFDCPVHLIKEYGGWRNRKMVGFYENLARAIFTRYKGLVRYWLTFNEINMLLHAPFMGAGLVFEEGENKEQAKYLAAHHELLASALATKIGHEVDPENKIGCMLAAGDYYPFDCNPENVFEAQKQNHDNLFFIDVQSRGKYPNYLLKRLEREEITLPIEKGDLEILAENTVDFISFSYYASRVAKVKDEDADKSAGNIFESVKNPYLEASEWGWQIDPLGLRITMNSIYDRYQKPLFIVENGLGAVDKPDENGFVADDYRIDYMAAHIKEMKKAVELDGVELLGYTSWGCIDLVSAGTGEMSKRYGFIYVDRDDYGKGSLKRTPKKSFNWYKKVIASNGEDLTNE
>NC_020450.1|WP_015426857.1|1792722_1795428_-|YhgE/Pip-domain-containing-protein
MKSIKNTWKLFALDWKRIFKNPVATFLIVALMIIPSLYAWFNIKALWDPYANTSQLPIAVYSADKSASFQDKTINIGDEVLKNLKKNHQLGWKFVDSKADLDKGVKSGKYYAGIYLPKDFSKDLLSFTTGDIKKPQIVYSINEKINAIAPKITSKGASSLQSQISEEFIKTASSTLLKTFNTIGYDIDKNMISIQKVKSAILSTNDNLGTIDKYTQQVVDLHGKMPEIKEKLAKANEFITYLPEVDALGQKVIKLNDKMPEIDKSFSLVLTLQEKIPEIQNAGKQISMIDDDFASVESTMTQGIQEAKQGLQIINQVQKSMPDIKKLGQDADSLGTITLDAAKKMQSALPSITNSVQITLQSIQEFSKNTSSVISVIDQAIADNQLTDDEKEQINSLITNFTNNIAKQREAIQNIVEYMKQVQESNGNHDLDSTIEQLTNLDSLLSELSTRMSHLNDLVQEGDVSKIRAYLSQINDVVNNISDLISKIDVSEISSTINNALTTLINTITDAKGLLNQAQQIDFDALLNSTSQTVSNAITILEKYQGEMPAIKQEIHDANVMLNGNMTTIVNAINEGANLYKNEFPTLKTKLGTASDFFKNDYAGVRKDLTDTLTMANDKMPDVESALNQANDLIQNDWPEIKSGIQKAAAAIQKGEKEVDLGEIVKLLKLDATKESDFLTQPVEVQENQIYPIANNGSASTPFYTALCLWVGAVLLSSLATTEVHLSDKDKKRYSKREQFFARMGSFVAIGLAQALIVTLGNYFGLGVDVRDPFYSVLFALLISIAFMIMVYVLVALFGNVGKGIAIIILVLSISGGGGNYPIQVSGKFFQAINPYLPFTHAVNLLRESAGGIYWPNAWFAIIILVAVSIVFVAIGAFLFPHFEDKTKKISEIGSKSHFFH
>NC_020450.1|WP_015426856.1|1791884_1792625_-|demethylmenaquinone-methyltransferase
MTKVNEERVQEIFNSISSDYDKMNAIISFKQHDLWRAKTMKRMGDLTGLSILDLCCGTGDWTFDLSESVGPSGKVIGLDFSENMLEIAKAKLKEEAKKNIEFLQGNAMALPFENESFDVVTIGYGLRNTPDYLTVLKEIFRVLKPGGRVVCIETSHPTLPIYKQAFELYFKNVMPFFGKVFAKSLKEYQWLQKSAEDFPDAKTLEELFRKAGFVAVEYQKHGGGAIASHFATKSKKPKSNIRIGKK
>NC_020450.1|WP_015426855.1|1791014_1791848_-|Rgg/GadR/MutR-family-transcriptional-regulator
MPYKRYGEIFKKLREQKNFSLSHFSEIGISKASLSRFELGQTMISFERLDSALQEMNVTLAEYEHFINNFSMDYKEEFLEDIILADIVDDVDKLHNLYLEAMEYDSKMLAYCAKSRYEILTQTEADDVVEYLYDVGEWGYFELSIFYLTLDSFSEREIMYLMKELWGKSKHLYGVFKYRRTVLQSSYRAVVLLSSKGARDSAKSILQKSYPKDDFYDLYVENLRNLAHGFYSYCFKDKISGEKQIKNAIEIFRQVGYKDLADYYQKRYQKLLGKLLT
>NC_020450.1|WP_015426865.1|1806982_1808557_-|alpha-amylase
MKNKLLLLSVTLLATCALSACQKANSKDSSVKKVAVSQKVDRSLYRNFYEIFTSSFADSNHDGEGDLNGVTQHLDYLNTGKSNSTTDLKVQGLWMTPIFASPSYHGYDVTNYEEINPKFGTMADFENLIAQAKKRGIAVILDMPFNHTATDNVWFQKALAGDKKYVAYYNWSDTAKEGYSLASNGKYYESEFDKSMPDLNLANPEVKKEIAKITKFWLDKGVSGFRLDAVGFYFSNDDKKTTAFTKWLTDTVKKQNPKAYLVGEVFSTASAIDDIYPSGIDSLFDFPNALQSSSSPINSALVLGEGSLFGQQIEAWDQEIHADNPKAIDAPFLSNHDTDRSATLLSSLSMQKMAAQTYLLMPGNPFIYYGEELGLTGSGIDQNKRLPMPWNAAGTDSPKADISVPGATEIATTDGGSVAQQEANPNSLLNWYKKILRVKAKYPEIATDRLKNISVSEESLSVINYGKDLTIINNFSDTENVTMKLPKSVVGTKITDQLSVSSSQAKLTDGKLTIPAYSTVILKK
>NC_020450.1|WP_021470128.1|1808546_1809152_-|sugar-O-acetyltransferase
MSEFKRMVAGKLYKASKVEPEYKPDNNRALNQEINQLNLLDTEKIVALEKELFGQTGDELFVNPPLYIDYGKNTRIGQRFYANMDCIFLDVAPITIGDDVMFGPRVSLITASHPIDAGVRQRGLEYGKAITIGNRVWLGAGVIVNPGVTIGENTIVGSGTVVTKNLPANVIAVGNPARILREITDSDRLYWEEKENEYYEK
>NC_020450.1|WP_042230778.1|1809178_1810774_-|alpha-glucosidase
MKENWWQKTVVYQIYPRSFMDANGDGVGDLQGIISKLDYLEKLGIGAIWLSPVYQSPMDDNGYDISDYQAIADVFGTMSDMDELLLEAKKRNIQIVMDLVVNHTSDEHKWFVEARKSKDNAYRDYYIWADEPNALQSTFSGSAWEFDEESGQYFLHLFSKRQPDLNWENPQVHQEVYDMMNFWIDKGIGGFRMDVIDLIGKEIDQEITGNGPKLHEYLHEMNQATFGQKNLLTVGETWGATPEIAELYSDPKRQELSMVFQFEHITNAYLDEGEKWDKKEFSVSKLKEILAKWQALEKGWNSLFWNNHDLPRIVSNWGNDGKYRLKSAKAFAILLHLMKGTPYIYQGEELGMTNYPFESIEEVNDIESRNMFAERLAAGHSENEIMDSIRRVGRDNARTPMQWTAGENAGFTDGKPWLAVNPNHEEINADQAMSDPDSVFYTYQKLIELRKQHDWVIYGGFKLIDSEADVFAYLRTYKGKKYLVVANLSDEENQFKTGFVCRDLLIHNENFLPELSQIKLKAWEAFACEVE
>NC_020450.1|WP_015426868.1|1811010_1812765_-|alpha-glycosidase
MNKAAIYHRPESEFAYLYAKNLMHVRLQTQKSDVEKVELFYGDPYSWEGVDNPKTQYWASQKVEMKKYLSTNISDYFEAEITVATKRVDYLFVITGLDGEKVVYTDQGMFDYDESLVTKKYGAFRLPYFHESDRFKAPEWVKETVWYQIFPERFANGDTSNDPEGTKAWNPQDVPDRQDFYGGDLQGVIDHLEHLTELGVNGIYFTPIFQAFSNHKYDTEDYMEIDKQFGDKELFKTLVKEAHARGIKVMLDAVFNHIGDTSAQWQDVLKNQEKSKFADWFHVNSWPATYTPTDDFENAENATYDTFAFTPHMPKLNTANPEVEAYLLKVADYWISEFDIDAWRLDVADEVDHTFWKKFRTTCDAAKDDFYILGEVWHSAQPWLVGDEFSAVMNYAYTDAIKDGLITKKISLEQMVSNINTQLTLYRKQVNQMMFNVLDSHDTPRILTVAKNNKNLMKLVETFTFMQPGVPCIYYGDEYAVTGGMDPECRKVMPWEEKDQDLEMFEFFKNLIALRKQYQGILSDSEVEWKIVDSENGIVKFERGTLKAIFNIGEKPAYFSADEVVFSNLVDQNNILQYGFVVYK
>NC_020450.1|WP_015426869.1|1813132_1814359_+|extracellular-solute-binding-protein
MKSWKKVALGGASVLALATLAACGSSASSNKSSSSSSDSIKGTVRVYVDTQQKATYTDVAKGLASKYPDLKVQIIANASGSANAKVDIAKDPSKYADVFAVPNDQLGDMADKGYINPVATKFANEIKKDNSDVTVNGVTYKDKIYAFPKSTESLVLFYNKSKLSADDVKTWEGMTAKAGFAANYTDPYYSYPVFFTAGTTLFGKSGEDVKSTDVASANGVKALEWIAAQKSNKNVIQTTNALNQLQAGKVAAMFDGPWDTANIKKILGDNFAVAPYPTINIDGQAKQLQSFQGIKGFAVNSASKSQAAAQTVAQYLSSESAQLKLFNSQGDVPTNNDAQMNDAVKNSDVTKAVITMSKEGNSVVMPKLPQMATFWNNAGPLMNGAYTGSIKPADYQAQLQKFQDSISK
>NC_020450.1|WP_042230779.1|1814475_1815819_+|sugar-ABC-transporter-permease
MSPEEKSIKLGEVFSKGDTVTKLTFFVMGLNQIKNKQWVKGFTLLILEIAFIGWLLFSGISAFSLLSSLGPNKIKRTITDASGFPQTLQPDNSVLILLWGLIACLVVILFILLYWFNYRSNKHLYYLKREGKHIPTNKEELASLLDEKLYATLMAVPLIGVLAFTVLPTVYMISMAFTNYDRLHATAFSWTGFQAFGNVLTGDLAGTFFPVLGWTLVWAIVATATTFLGGVLLALLIESTGIKFKGFWRTIFVIVFAVPQFVTLLMMAQFLDQQGALNGILMNLHLISNPINFIGAASDPMVARITVIFVNMWIGIPVSMLVSTAIIQNLPQDQIEAARIDGANSLNIFRSITFPQILFVMTPALIQQFIGNINNFNVIYLLTSGWPMNPNYQGAGSTDLLVTWLYNLVFGQTQRYNAAAVLGILIFIVNASISLVAYRRTNAFKEG
>NC_020450.1|WP_015426871.1|1815824_1816691_+|sugar-ABC-transporter-permease
MKSYKTQRRISLSLRYILLALLAIVWIFPIIWIVLASLTQNNTGFVSTIIPKTFTFENYIQLFQNKSGSFPFVSWIINTFIVAVISATLSTFITIIMSYTLSRLRFAFRKPFLQIALVLGMFPGFMSMIALYYILKAMNMLNLGGLILVYVGGAGLGFYIAKGFFDTIPRSIDEAATIDGANKWQVFTHITLPLSRPIIVYTALMAFIAPWTDFIFSGIILGNNQAHPETFTIAYGLYSMVHSQKGAATAFFTQFIAGCVIIAIPITILFVIMQKFYVNGITAGADKG
>NC_020450.1|WP_015426872.1|1816850_1817846_+|hypothetical-protein
MKKFFIIIFAIFSIGILSSCKTSSKDSIKTNTNPHQAIQGEWISYSESKINLPKTTSAADAHKLLDLTASTSEKIKFDKKRVTLATNEYDYKLGRQIIIGSYSYDYKLEHGQDILKFDMTSSDIGGNVYYRVGSKLEKEKTKEINDKEAKEKKSVTHLNEVWKAKTDIIEKSLKVAMIGTWAGHFKSVATTGQGVAWAPGMQTLTFDGGTNLSFHASSDSLTNFDQKVIHNAYASYQPNGILGLEPSDHIPVDPKKLLNIIKDLTAEQMFSRIKYIAFSYDVTTDTGTISQSFSPSELSYKNGKLSFDTALLITQCGNEGVQISGDVSKTE
>NC_020450.1|WP_039115764.1|1817851_1818796_+|hypothetical-protein
MKNKIIVVAILITTFFSLSACSKLTKSESTLIKGQWELLQGPIQVTSNLKLLDFPNKSTSIVNFTKEKNYHFNEKKHELSYLNSYKYQTSFDISGNILTLTNKKQKMIYYRKNSVQYKKAITPIKNNMNSVNEVWKAQNQSFLKDYEEAIAGDWSNAKGNAQVNLNHDSPDPDATLTISTPKFLFFDISFTGGARDKTMSVNFKDKNISDAAIKLSYSDFDTLLGLGWNASENLNETKEKIKKITFRDLFMDLEEVTLAYSIPDSTLSQEITVSAYRATVSSNITHFDECTITTKDSSTDHEFKAYLTPVETTN
>NC_020450.1|WP_015426874.1|1818797_1819355_+|hypothetical-protein
MNLFSLKLLLIPILVLSPLVLLLIEKLTKKKYITAKNISEDVIKADEIEALVLAVLSSWNQSKLYQNSQFYSKNLLKKQDKHIVHNDMYGKKESIFDIQIEGINNLHQFKNKITVEISLKAKYSLSFDENDSLMYLVTSRSMSRYNEMLKDPLPDRQTYQKDVQKWEFVIEENLFKVNKFSSNLK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

378845 : 390973

Streptococcus_phage(40.0%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015425840.1\|378845_379163_+	thioredoxin family protein	A0A0K2FIM3	Achromobacter_phage	7.7e-05	30.4
WP_015425841.1\|379248_379875_+\|tRNA	DUF4479 and tRNA-binding domain-containing protein	NA	NA	NA	NA
WP_015425842.1\|380036_381377_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_015425843.1\|381465_381855_+	single-stranded DNA-binding protein	A0A0K0MWE1	Streptococcus_phage	1.1e-24	45.8
WP_003131589.1\|381974_382259_+	co-chaperone GroES	A0A221S386	uncultured_virus	3.1e-13	44.1
WP_015425845.1\|382346_383975_+	chaperonin GroEL	A0A219YK78	uncultured_virus	4.9e-156	56.8
WP_003131583.1\|384020_384833_-	MBL fold metallo-hydrolase	A0A0C5AJ83	Bacteriophage	3.1e-34	38.1
WP_015425846.1\|385002_386445_-	cell wall metabolism sensor histidine kinase WalK	W8CYF6	Bacillus_phage	1.4e-32	33.0
WP_003131580.1\|386437_387139_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.2e-42	39.7
WP_015425847.1\|387316_387952_+	dTMP kinase	M1PSC7	Streptococcus_phage	3.1e-74	65.0
WP_015425848.1\|388084_388945_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	5.0e-67	45.5
WP_015425849.1\|388996_389779_+	stage 0 sporulation family protein	NA	NA	NA	NA
WP_015425850.1\|389771_390098_+	DNA replication initiation control protein YabA	NA	NA	NA	NA
WP_015425851.1\|390097_390973_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	8.7e-99	65.4

DBSCAN-SWA_2

992267 : 1015724

Staphylococcus_phage(21.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015426249.1\|992267_992960_+	cell division ATP-binding protein FtsE	G9BWD6	Planktothrix_phage	2.7e-31	34.4
WP_015426250.1\|992952_993888_+	ABC transporter permease	NA	NA	NA	NA
WP_015426251.1\|993991_994969_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A096XT60	Enterococcus_phage	1.1e-118	66.0
WP_015426252.1\|995318_997487_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	8.6e-257	61.0
WP_003130968.1\|997622_998045_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A142F1R4	Bacillus_phage	2.3e-12	37.3
WP_042230256.1\|998046_998265_-	redoxin NrdH	A0A1W6JHV4	Lactococcus_phage	1.3e-11	47.6
WP_010905665.1\|998438_999080_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_012897614.1\|999354_1001289_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	1.1e-125	43.5
WP_015426254.1\|1001492_1002032_+	cysteine hydrolase family protein	NA	NA	NA	NA
WP_003130976.1\|1002024_1002858_+	3'-5' exonuclease	A0A0K2SUJ2	Clostridium_phage	3.1e-21	39.4
WP_015426255.1\|1002854_1003304_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_015426256.1\|1003579_1006054_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	1.1e-98	32.5
WP_015426257.1\|1006079_1006985_-	magnesium transporter CorA family protein	NA	NA	NA	NA
WP_015426258.1\|1007454_1008543_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	2.4e-50	38.5
WP_015426259.1\|1008542_1009193_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.6e-41	43.4
WP_015426260.1\|1009201_1010398_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	7.9e-111	50.8
WP_015426261.1\|1010425_1010890_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	2.8e-40	55.7
WP_012897620.1\|1010992_1011445_+	lipoprotein signal peptidase	NA	NA	NA	NA
WP_003130995.1\|1011506_1012412_+	RluA family pseudouridine synthase	A0A2H4UV25	Bodo_saltans_virus	5.4e-11	28.2
WP_015426262.1\|1012559_1013003_+	divergent PAP2 family protein	NA	NA	NA	NA
WP_015426263.1\|1013142_1014765_+	glycosyltransferase family 39 protein	NA	NA	NA	NA
WP_015426264.1\|1014767_1015724_+	glycosyltransferase family 2 protein	I1TED8	Salmonella_phage	4.0e-49	37.5

DBSCAN-SWA_3

1716916 : 1759783

Lactococcus_phage(89.58%)

portal,head,integrase,holin,protease,capsid,tail,terminase

attL 1704107:1704124|attR 1757890:1757907

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1704107:1704124	attL	NA	NA	NA	NA
WP_014570681.1\|1716916_1717117_-	cold-shock protein	Q9AZD3	Lactococcus_phage	1.4e-28	93.9
WP_170275335.1\|1718319_1718463_-	hypothetical protein	NA	NA	NA	NA
WP_042230494.1\|1718537_1719419_-	hypothetical protein	NA	NA	NA	NA
WP_015426784.1\|1719789_1720194_-	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	3.7e-28	49.6
WP_015426785.1\|1720286_1721627_-	LysM peptidoglycan-binding domain-containing protein	A0A1P8BMS7	Lactococcus_phage	5.4e-209	81.9
WP_042230496.1\|1721623_1721848_-\|holin	holin	A0A1P8BL93	Lactococcus_phage	1.2e-33	97.3
WP_012897995.1\|1721861_1722083_-	hemolysin XhlA family protein	A0A191KBQ1	Streptococcus_virus	1.5e-20	65.3
WP_015426786.1\|1722100_1723174_-	hypothetical protein	A0A059NTA1	Lactococcus_phage	2.3e-29	84.4
WP_162838863.1\|1723173_1723311_-	hypothetical protein	NA	NA	NA	NA
WP_015426787.1\|1723307_1725845_-	hypothetical protein	A0A059NT86	Lactococcus_phage	0.0e+00	92.2
WP_015426788.1\|1725856_1726222_-	hypothetical protein	A0A059NT91	Lactococcus_phage	9.3e-63	98.3
WP_042230499.1\|1726233_1731015_-\|tail	tail protein	A0A059NT57	Lactococcus_phage	0.0e+00	82.9
WP_015426790.1\|1731046_1731418_-	hypothetical protein	A0A172LN91	Lactococcus_phage	2.3e-40	67.5
WP_015426791.1\|1731441_1731852_-	hypothetical protein	A0A182BQ86	Lactococcus_phage	2.0e-50	75.0
WP_015426792.1\|1731925_1732357_-\|tail	major tail protein	A0A182BQ87	Lactococcus_phage	2.6e-64	87.9
WP_015426793.1\|1732369_1732732_-	hypothetical protein	A0A059NT89	Lactococcus_phage	1.8e-58	95.8
WP_015426794.1\|1732731_1733280_-	hypothetical protein	A0A182BQ89	Lactococcus_phage	3.3e-96	97.8
WP_015426795.1\|1733263_1733611_-	hypothetical protein	A0A059NT74	Lactococcus_phage	5.2e-47	82.9
WP_015426796.1\|1733591_1733924_-\|head,tail	phage head-tail connector protein	A0A059NT99	Lactococcus_phage	5.0e-55	99.1
WP_015426797.1\|1733944_1735063_-	Ig-like domain-containing protein	A0A059NT82	Lactococcus_phage	2.9e-163	97.4
WP_015426798.1\|1735074_1735731_-	DUF4355 domain-containing protein	A0A182BQ92	Lactococcus_phage	1.9e-82	88.1
WP_015426799.1\|1735895_1737002_-\|capsid	minor capsid protein	A0A059NT80	Lactococcus_phage	1.0e-197	97.0
WP_015426800.1\|1737006_1737294_-\|protease	ribosomal-processing cysteine protease Prp	A0A182BQ95	Lactococcus_phage	5.6e-47	96.8
WP_170275344.1\|1737290_1737455_-	hypothetical protein	NA	NA	NA	NA
WP_015426801.1\|1737411_1738920_-\|portal	phage portal protein	A0A182BQ97	Lactococcus_phage	5.3e-229	94.5
WP_042230502.1\|1738929_1740213_-\|terminase	PBSX family phage terminase large subunit	A0A1B1UZZ1	Enterococcus_phage	1.9e-203	82.6
WP_042230504.1\|1740205_1740658_-\|terminase	terminase small subunit	D7RWC4	Brochothrix_phage	1.3e-18	41.1
WP_014024904.1\|1740943_1741366_-	DUF722 domain-containing protein	A0A182BQA1	Lactococcus_phage	2.7e-58	100.0
WP_015426807.1\|1742296_1742506_+	hypothetical protein	NA	NA	NA	NA
WP_042230506.1\|1742554_1742710_-	hypothetical protein	Q9AZT8	Lactococcus_phage	2.2e-21	96.1
WP_042230508.1\|1742706_1742889_-	hypothetical protein	Q9AZZ4	Lactococcus_phage	1.6e-28	98.3
WP_015426809.1\|1742885_1743185_-	hypothetical protein	Q9AZZ5	Lactococcus_phage	1.4e-45	93.9
WP_148284416.1\|1743231_1743615_-	hypothetical protein	V9VHY9	Lactococcus_phage	9.4e-58	83.5
WP_042230510.1\|1743617_1744007_-	hypothetical protein	A0A1P8BKY9	Lactococcus_phage	3.1e-32	62.8
WP_042230512.1\|1743999_1744206_-	hypothetical protein	NA	NA	NA	NA
WP_148284417.1\|1744189_1744450_-	6-O-methylguanine DNA methyltransferase	NA	NA	NA	NA
WP_015426814.1\|1744442_1744763_-	hypothetical protein	NA	NA	NA	NA
WP_042230514.1\|1744755_1744983_-	hypothetical protein	NA	NA	NA	NA
WP_042230516.1\|1744979_1745174_-	hypothetical protein	NA	NA	NA	NA
WP_080619352.1\|1745170_1745674_-	DUF1642 domain-containing protein	A0A059NT63	Lactococcus_phage	1.4e-37	60.1
WP_042230518.1\|1745750_1745930_-	hypothetical protein	A0A1P8BKQ8	Lactococcus_phage	7.5e-26	96.6
WP_015426816.1\|1745938_1746448_-	hypothetical protein	Q9AZU7	Lactococcus_phage	1.4e-11	97.3
WP_015426817.1\|1746471_1746888_-	hypothetical protein	A5GZ50	Lactococcus_phage	1.2e-74	97.8
WP_042230520.1\|1746900_1747143_-	hypothetical protein	A5GZ49	Lactococcus_phage	3.0e-41	98.8
WP_042230522.1\|1747135_1748035_-	phage replisome organizer N-terminal domain-containing protein	A5GZ47	Lactococcus_phage	9.3e-72	62.5
WP_015426819.1\|1748159_1748732_-	single-stranded DNA-binding protein	Q0ILF2	Lactococcus_phage	2.8e-53	100.0
WP_015426820.1\|1748745_1749237_-	ERF family protein	A0A1P8BMK8	Lactococcus_phage	9.3e-58	97.4
WP_015426821.1\|1749245_1749641_-	hypothetical protein	A0A1P8BL23	Lactococcus_phage	4.2e-69	99.2
WP_015426822.1\|1749742_1749979_-	DUF1408 domain-containing protein	Q9MC36	Lactococcus_phage	6.0e-39	98.7
WP_042230523.1\|1750082_1750517_+	hypothetical protein	NA	NA	NA	NA
WP_158414574.1\|1750506_1750659_-	hypothetical protein	NA	NA	NA	NA
WP_011834775.1\|1750813_1751050_-	helix-turn-helix domain-containing protein	A0A059NT59	Lactococcus_phage	4.3e-37	100.0
WP_015426824.1\|1751062_1751776_-	phage antirepressor Ant	A0A059NT90	Lactococcus_phage	3.5e-130	99.6
WP_015426825.1\|1751785_1752001_-	hypothetical protein	A0A1P8BKX2	Lactococcus_phage	5.0e-32	100.0
WP_042230525.1\|1752012_1752243_-	hypothetical protein	Q77NT7	Lactococcus_phage	5.7e-34	97.4
WP_015426827.1\|1752396_1752852_+	hypothetical protein	NA	NA	NA	NA
WP_042230528.1\|1753171_1753690_+	helix-turn-helix domain-containing protein	A0A1B1IMU5	Lactococcus_phage	1.0e-51	91.5
WP_015426829.1\|1753699_1754287_+	hypothetical protein	Q9AZW4	Lactococcus_phage	9.0e-92	83.0
WP_015426830.1\|1754344_1754926_+	hypothetical protein	A0A182BQD0	Lactococcus_phage	2.2e-42	71.2
WP_042230530.1\|1755046_1756180_+\|integrase	site-specific integrase	A0A059NT56	Lactococcus_phage	9.2e-202	98.1
WP_015426832.1\|1756374_1757349_-	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_012898240.1\|1757360_1758302_-	sugar ABC transporter permease	NA	NA	NA	NA
1757890:1757907	attR	NA	NA	NA	NA
WP_042230532.1\|1758304_1759783_-	sugar ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.5e-15	31.4

DBSCAN-SWA_4

1847219 : 1857078

Prochlorococcus_phage(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003130886.1\|1847219_1847981_-	phosphate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.5e-17	30.0
WP_003130885.1\|1848146_1848956_-	phosphate ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.0e-10	26.5
WP_015426897.1\|1848989_1849883_-	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_015426898.1\|1849882_1850806_-	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_015426899.1\|1850926_1851778_-	phosphate ABC transporter substrate-binding protein	E3SNT9	Prochlorococcus_phage	4.2e-05	27.3
WP_015426900.1\|1852124_1853021_-	phosphate ABC transporter substrate-binding protein	E3SM63	Prochlorococcus_phage	7.2e-08	32.4
WP_003130878.1\|1853298_1853766_-	SsrA-binding protein SmpB	W5RAM5	Staphylococcus_phage	2.7e-43	56.6
WP_042230561.1\|1853797_1854355_-	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_015426902.1\|1854459_1857078_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	4.2e-64	33.3

DBSCAN-SWA_5

1966561 : 1980712

Lactococcus_phage(81.82%)

capsid,integrase

attL 1960209:1960228|attR 1976454:1976473

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1960209:1960228	attL	NA	NA	NA	NA
WP_015426976.1\|1966561_1967080_-	HNH endonuclease	Q8LTL4	Lactococcus_phage	2.2e-97	95.9
WP_015426977.1\|1967070_1967406_-	sigma-70 family RNA polymerase sigma factor	Q9AZI1	Lactococcus_phage	2.3e-31	69.8
WP_015426979.1\|1968183_1969413_-\|capsid	phage major capsid protein	E9LUQ3	Lactobacillus_phage	1.7e-140	61.6
WP_015426980.1\|1969589_1970168_-	hypothetical protein	Q9AZE4	Lactococcus_phage	8.5e-103	97.4
WP_015426981.1\|1970186_1970642_-	hypothetical protein	NA	NA	NA	NA
WP_015426982.1\|1970902_1972507_-	hypothetical protein	NA	NA	NA	NA
WP_015426983.1\|1972499_1973078_-	hypothetical protein	Q9AZE6	Lactococcus_phage	1.2e-88	93.8
WP_015426984.1\|1973086_1973356_-	hypothetical protein	Q9AZH3	Lactococcus_phage	3.3e-25	70.8
WP_015426985.1\|1973352_1973505_-	hypothetical protein	Q9AZH4	Lactococcus_phage	2.2e-10	62.0
WP_015426986.1\|1973501_1973654_-	hypothetical protein	NA	NA	NA	NA
WP_042230587.1\|1973650_1973854_-	DUF1655 domain-containing protein	Q9AZJ4	Lactococcus_phage	1.0e-26	92.2
WP_042230588.1\|1974207_1974417_-	helix-turn-helix transcriptional regulator	Q8LTL6	Lactococcus_phage	3.7e-16	71.2
WP_015426989.1\|1974546_1975038_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_042230589.1\|1975155_1976355_+\|integrase	site-specific integrase	Q9AZI0	Lactococcus_phage	1.9e-176	77.4
WP_015426991.1\|1976501_1976945_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
1976454:1976473	attR	NA	NA	NA	NA
WP_015426992.1\|1976990_1977572_-	uracil-DNA glycosylase family protein	NA	NA	NA	NA
WP_015426993.1\|1977889_1980712_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	5.0e-305	56.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_020450

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection