CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021177	Streptomyces fulvissimus DSM 40593, complete sequence	22 crisprs	csa3,DEDDh,WYL,cas4,cas3,DinG,RT	0	9	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_021177_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_1

1253170-1253348

Orphan

Consensus_repeat	Method
CCGTCGATGGCGTCGTTGTAGTT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_021177_1

>merge|NC_021177|1|1253170-1253348|CRISPRCasFinder
CCGTCGATCGCGCCGGTGTAGCCGTAGTGCGCCTTCAGCCAACGCTGCAGCGCCTTCACCGTGTTGGGTCCGACGACTCCGTCGATGGCGTCGTTGTAGTTGGCGGCCGACCTCAGGAACCGCTGGAAGGCCTTCCAGCTGTTGGTCCCGAGCTGCCCGTCGATCGCGTCGTTGTAGTT

>NC_021177|1|1|1253170-1253348|CRISPRCasFinder
CCGTCGATCGCGCCGGTGTAGCC	GTAGTGCGCCTTCAGCCAACGCTGCAGCGCCTTCACCGTGTTGGGTCCGACGACT
CCGTCGATGGCGTCGTTGTAGTT	GGCGGCCGACCTCAGGAACCGCTGGAAGGCCTTCCAGCTGTTGGTCCCGAGCTGC
CCGTCGATCGCGTCGTTGTAGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015607454.1\|1253871_1254681_-\|LysR-family-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|176106
NC_021177.1\|WP_015607457.1\|1255802_1256972_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_021177.1\|WP_078618641.1\|1259363_1260380_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_021177.1\|WP_015607445.1\|1246050_1246980_-\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|234869
NC_021177.1\|WP_015607450.1\|1251014_1251968_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015607458.1\|1257058_1257634_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NC_021177.1\|WP_015607461.1\|1260430_1260634_+\|DUF1918-domain-containing-protein	unknown	unknown	gnl\|CDD\|378101
NC_021177.1\|WP_015607463.1\|1262144_1263005_+\|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|181133
NC_021177.1\|WP_015607444.1\|1244833_1246054_-\|acetylornithine-transaminase	unknown	unknown	gnl\|CDD\|235112
NC_021177.1\|WP_015607443.1\|1244271_1244808_-\|arginine-repressor	unknown	unknown	gnl\|CDD\|235116
NC_021177.1\|WP_015607451.1\|1251979_1252501_+\|ATP/GTP-binding-protein	unknown	unknown	gnl\|CDD\|379082
NC_021177.1\|WP_015607446.1\|1246976_1248131_-\|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ	unknown	unknown	gnl\|CDD\|235441
NC_021177.1\|WP_015607449.1\|1249738_1250626_-\|bile-acid:sodium-symporter-family-protein	unknown	unknown	gnl\|CDD\|223462
NC_021177.1\|WP_015607447.1\|1248127_1249156_-\|N-acetyl-gamma-glutamyl-phosphate-reductase	unknown	unknown	gnl\|CDD\|234761
NC_021177.1\|WP_015607448.1\|1249289_1249688_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379731
NC_021177.1\|WP_015607459.1\|1257895_1259365_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NC_021177.1\|WP_015607452.1\|1252554_1252884_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015607455.1\|1254739_1255132_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015607456.1\|1255219_1255717_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|238907
NC_021177.1\|WP_043971743.1\|1260677_1261916_-\|family-10-glycosylhydrolase	unknown	unknown	gnl\|CDD\|224563

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015607454.1\|1253871_1254681_-\|LysR-family-substrate-binding-domain-containing-protein	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	7.85388e-25
NC_021177.1\|WP_015607457.1\|1255802_1256972_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	6.41278e-60
NC_021177.1\|WP_078618641.1\|1259363_1260380_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	5.53484e-15
NC_021177.1\|WP_015607445.1\|1246050_1246980_-\|acetylglutamate-kinase	gnl\|CDD\|234869	PRK00942, PRK00942, acetylglutamate kinase; Provisional.	1.7267e-149
NC_021177.1\|WP_015607458.1\|1257058_1257634_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.81599e-20
NC_021177.1\|WP_015607461.1\|1260430_1260634_+\|DUF1918-domain-containing-protein	gnl\|CDD\|378101	pfam08940, DUF1918, Domain of unknown function (DUF1918). This domain, found in various hypothetical bacterial proteins, has no known function.	7.01986e-23
NC_021177.1\|WP_015607463.1\|1262144_1263005_+\|3-hydroxybutyryl-CoA-dehydrogenase	gnl\|CDD\|181133	PRK07819, PRK07819, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	0
NC_021177.1\|WP_015607444.1\|1244833_1246054_-\|acetylornithine-transaminase	gnl\|CDD\|235112	PRK03244, argD, acetylornithine transaminase.	0
NC_021177.1\|WP_015607443.1\|1244271_1244808_-\|arginine-repressor	gnl\|CDD\|235116	PRK03341, PRK03341, arginine repressor; Provisional.	4.06311e-86
NC_021177.1\|WP_015607451.1\|1251979_1252501_+\|ATP/GTP-binding-protein	gnl\|CDD\|379082	pfam13238, AAA_18, AAA domain.	0.000178361
NC_021177.1\|WP_015607446.1\|1246976_1248131_-\|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ	gnl\|CDD\|235441	PRK05388, argJ, bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ.	0
NC_021177.1\|WP_015607449.1\|1249738_1250626_-\|bile-acid:sodium-symporter-family-protein	gnl\|CDD\|223462	COG0385, COG0385, Predicted Na+-dependent transporter [General function prediction only].	7.2757e-57
NC_021177.1\|WP_015607447.1\|1248127_1249156_-\|N-acetyl-gamma-glutamyl-phosphate-reductase	gnl\|CDD\|234761	PRK00436, argC, N-acetyl-gamma-glutamyl-phosphate reductase; Validated.	7.66683e-175
NC_021177.1\|WP_015607448.1\|1249289_1249688_+\|hypothetical-protein	gnl\|CDD\|379731	pfam15585, Imm7, Immunity protein 7. A predicted immunity protein with an alpha+beta fold and a conserved GxaG motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a Tox-REase-3 domain.	5.21086e-62
NC_021177.1\|WP_015607459.1\|1257895_1259365_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.07459e-98
NC_021177.1\|WP_015607456.1\|1255219_1255717_-\|peptidylprolyl-isomerase	gnl\|CDD\|238907	cd01926, cyclophilin_ABH_like, cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. These enzymes have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. As cyclophilins, Human hCyP-A, human cyclophilin-B (hCyP-19), S. cerevisiae Cpr1 and C. elegans Cyp-3, are inhibited by the immunosuppressive drug cyclopsporin A (CsA). CsA binds to the PPIase active site. Cyp-3. S. cerevisiae Cpr1 interacts with the Rpd3 - Sin3 complex and in addition is a component of the Set3 complex. S. cerevisiae Cpr1 has also been shown to have a role in Zpr1p nuclear transport. Human cyclophilin H associates with the [U4/U6.U5] tri-snRNP particles of the splicesome.	4.64238e-108
NC_021177.1\|WP_043971743.1\|1260677_1261916_-\|family-10-glycosylhydrolase	gnl\|CDD\|224563	COG1649, COG1649, Uncharacterized protein conserved in bacteria [Function unknown].	1.9875e-87

>NC_021177.1|WP_015607452.1|1252554_1252884_-|hypothetical-protein
MANAKTSYVCLPCRASYKQPYDSTRQRICPRCAEPLIHAGSAFAVPRRRDVAAWRTLSVLLNAGVGFHKSCCGGPGYRPRTLREVRERMAYAGRSGEPIARALVRYDVP
>NC_021177.1|WP_015607451.1|1251979_1252501_+|ATP/GTP-binding-protein
MIVWLNGTHGAGKTTTSALVQQLIPDSRVFDAEKVGETLMDITPGLPGTDNFQHWPPWRPLVVETARHVLDYTGGTLVMPMTVLVEQYWREISAGLAQHSIPVRHFVLHADQETLRGRIEGDTDMGPSAFRLKYLAPYAEAARTWLHDEAEVIDTTHLTPTLAAQRITEAVTS
>NC_021177.1|WP_015607450.1|1251014_1251968_+|hypothetical-protein
MERWDRIGRGAAYGAALALLPYLLIKVVWVVGSLVGTLPVGTGFGVAEWVVLNTVTVGMAGIGVALALALVRPWGMRIPGALVAFCAWVGSGLLVSILPFGVLSTLLGAGADSQDGGDEPVRPVWEGLLVQFSFLGMGLGLALAVPAHLRRRWPQAFTGRVGDAPRAAPPWAAVVGAAVGLVWLYWAAGGTVGIAHPTERTTHGYALGAVSGFWALAGSAAVWMIARARPARLPRRLPLVFGWVGSGSLFAWSGWKLPFTLYAALAEPAGFTPPESPGAAVILHLGAVASGAAMLRILVRERERDRLTESRHRPTPH
>NC_021177.1|WP_015607449.1|1249738_1250626_-|bile-acid:sodium-symporter-family-protein
MNDSALITTGLPIALAIIMFGLGLSLTTDDFRRVTRSPKAVVVALVLQVLVLPLVAFGLVKIFDLDPLLAVGVMLLAASPGGTTANLFSHLFRGDVALNITLTAINSVLAAITIPIITNLAIDHFDAEGDLGLQLGKVVQVIAIVLIPVAVGMAVRRRSADFAARADRPVRIFSIVVLVIVSVGALLGERENLADYMQQVGLVTGIFCLASLTLGYAGARLLRLDKRQAIASSMEVGIHNTTVALTIALSVLESTEVAIPSAVYSVLMYVLATAFGYLITRRHSDAEKSLGQPAG
>NC_021177.1|WP_015607448.1|1249289_1249688_+|hypothetical-protein
MFEYHGWITVRESAAADDDEQPRLRQIADELRLRIALMDSPYLLDLRWMNGEPFIHLGGFSNHRSSPDVAELFEHVAEVAPGSYGLLHVRDDEDPGHENEVRVLRLVRGRITQHTETLLSPCIPTVEDPFTG
>NC_021177.1|WP_015607447.1|1248127_1249156_-|N-acetyl-gamma-glutamyl-phosphate-reductase
MVVRAAVAGASGYAGGELLRLLLVHPGVEIGALTGHSNAGQTLGSLQPHLRPLAGRVLEPTTAEVLAGHDVVFLALPHGQSAAVAEQLGDEVLVVDMGADFRLRDAGDWEKFYGSPHAGTWPYGLPELPGGRAVLAGSKRIAVPGCYPTAVSLALFPAYEAGIAEPEAVIVAASGTSGAGKAAKPHLLGSEVMGNMTPYGVGGGHRHTPEMIQNLSAAAGEPVTVSFTPTLAPMPRGILATCSAKAKPGVSAESLRAVYEKAFADEPFVDLLPEGQWPATAAVYGSNAVQVQVAHDEAAGRIVVICAIDNLAKGTAGGALQSMNIALGLPEDTGLSTIGVAP
>NC_021177.1|WP_015607446.1|1246976_1248131_-|bifunctional-glutamate-N-acetyltransferase/amino-acid-acetyltransferase-ArgJ
MSVTAAQGFSAAGIAAGIKESGNPDLALVVNNGPRRAAAGVFTSNRVKAAPVLWSEQVLKGGEVTAVVLNSGGANACTGPQGFQDTHATAEKVAEVLDGHSAGEVAVASTGLIGLLLPMDKLLPGIEQAAAALSEHGGEKAAIAIKTTDTVHKTAVAGGEGWTVGGMAKGAGMLAPGLATMLVVLTTDADVEAPVLDAALRDATRTTFDRIDSDGCMSTNDTVLLLASGASGITPEQGEFAEAVRAVCADLARQLIGDAEGASKDIRIEVINAATEDDAVEVGRSIARNNLLKCAIHGEDPNWGRVLSAIGTTKAAFEPDRLNVAINDVWVCKNGGVGEDRDLVDMRYREVKITADLSAGNESAIIWANDLTADYVHENSAYSS
>NC_021177.1|WP_015607445.1|1246050_1246980_-|acetylglutamate-kinase
MSAARKHTALPKAQILIEALPWLTRHNGKTVVIKFGGNAMIDEELKAAFAQDVVFLRHAGLKPVVVHGGGPQISAQLDKQGLVSEFKAGLRVTTPEAMDVVRMVLAGQVQRELVGLLNQHGPLAVGMTGEDAHTITAVQHRPTIDGESVDIGRVGEITAIDTGAIQALLDDGRIPVVSSIARSADDHHVYNVNADTAAAALAAALNAETLMVLTDVEGLYEDWPNSDDVISRLTASQLEKLLPELSSGMVPKMQGCLHAVRNGVETARVIDGRVQHSILLEIFTDEGIGTMVVPDAPIDVHTGPEQGES
>NC_021177.1|WP_015607444.1|1244833_1246054_-|acetylornithine-transaminase
MTGTEAIGTEAAGLTSRWQNALMDNYGTPQLPLVRGEGAHVWAEDGTRYLDFVGGIAVNALGHAHPAVVEAVSTQIASLGHVSNLFIAEPPVALAERLLQLFGRAGRVFFANSGAEANEAAFKIGRLTGRTHMVATDGGFHGRTMGALALTGQPGKREPFVPLPGDVTHVPYGDVDALRAAVTTETALVIIEPIQGENGVVVPPKGYLEAAREITRATGTLLVLDEVQTGIGRCGQWFEHQAHQGVEPDIVTLAKGLGGGLPIGAAVAFGPAADLLKPGHHGTTFGGNPIACAAGLAVLDTLAADGALDEVKRLGERIRDGVEALGHPLVSHVRGSGLLLGIVLTGPLAPQVQQAAQGAGLLVNAPAPDVVRLMPPLIIGDAEVDAFLEILPSALDAAHGDGRSGA
>NC_021177.1|WP_015607443.1|1244271_1244808_-|arginine-repressor
MTEAQETEHGGPSVPQTRTARHRRIVDILNRQPVRSQSQLAKLLADDGLSVTQATLSRDLDELGAVKIRNTGGELIYAVPSEGGFRTPQAPLGGSAKEERMRRLSAELLISAEASANLVVLRTPPGAAQFLASAIDQAELHDILGTIAGDDTLMLISRDAGGGQALADHLLRLAQNDR
>NC_021177.1|WP_015607454.1|1253871_1254681_-|LysR-family-substrate-binding-domain-containing-protein
MTGSDTPSAKPSSFRLAYVPGVTPTKWVRVWNERLPGNPLELVQVPAAEASRLLADGGAEAGLVRLPVDRDVLSAIPLYTETTVVVIPKDHVATAAEDVTLADLADEIVLHPLDDLLDWEKLPGSPAIERPATTADAIELVAAGVGVLLVPQSLARLHHRKDLTYRPVLDAPESRVALSWPQEEPTPDLVEEFIGIVRGRTVNSTRGRAVTPPQPSAKEKAKAKAKRAGTGGSTGRKPAPGKQTGAGGRRGGAPKGGQAGGKRGKPRGR
>NC_021177.1|WP_015607455.1|1254739_1255132_+|hypothetical-protein
MTSHKTAQTMKPATAAKKLGVYLQATPAEFQEGAVSRTELNALQTDPPAWLVELRRTGPHPRPVIAAKLGISIAGLARGGVADALTTEQVDALKDEMPEWLKKERATQAEVRKEAARIKERNAERAARSN
>NC_021177.1|WP_015607456.1|1255219_1255717_-|peptidylprolyl-isomerase
MTTKVYFDITINDAPAGRITFNLFDDVVPKTAENFRALATGEKGFGYAGSSFHRVITDFMLQGGDFTRGDGTGGKSIYGEKFADENFKLKHDRVGLLSMANAGPNTNGSQFFITTVLTPWLDGKHVVFGEVADEDSLALVRKIEALGSSSGRTSAKVTIAESGTL
>NC_021177.1|WP_015607457.1|1255802_1256972_-|serine-hydrolase
MPQIHGYCDDRFAGVRDAFEENFTARGELGAALTVLSDGIPVVDLWGGWADEARTRPWEQDTLVNVWSTGKGPTALCAHVLADRGLLDLDAPVAAYWPEFAANGKGSVLVRHLLSHRSGVAGVGVPHTLDELYDWELTCARLAATAPMWEPGTRSGYHAISYGFLVGEVVRRVSGVLPGEFLRQEITGPLGIDFTFGLPEKETRRLAELVQDRTDRAAQAALLARMQPVAVASLLNPPTGRAAANTPGWRAAEIPAANGHGTARAVAALYGILAGRGSLGSHRILSEQAVERVRESQGSCRDLVLGDAFAHETEIALGLWLSGRNRSYGPNPRAMGHDGAGGSCGLADPEAGIALGYVMNRMGSGVADDPRKTALVDAVYAAHRNAARG
>NC_021177.1|WP_015607458.1|1257058_1257634_-|histidine-phosphatase-family-protein
MTHRVTLVAAARTSPRLAERFDDDRPLDHAGWHEVQLVAHTLVPLGAAELRYCSPTPRSRATGDALGYAPMAQPALRDCDMGRWRGMTLAEVAAREPIAVDAWLADPGSAPHGGESLLGFIGRIGGWLDTRPACDGFIVAVAEPAVIRAALVYALNVPPTAYWNIDVRPLSTITLAGSPGRWSLSLESGIR
>NC_021177.1|WP_015607459.1|1257895_1259365_-|PLP-dependent-aminotransferase-family-protein
MQERSSVAELVTSLRSELNRYSPGGKLPSSRALVERFRVSPVTVSRAIAQLAAEGLVTTRPGSGAFRAEPRAEVPAPGDTSWQEVSLSGDGGPEVVPRTVDASGVLATLAAPPPGTIEFNGGYLHASLQPERALAAALARAGRRPGAWGRPPTDGLPELRSWFAREIGSAVSGSDVLITAGGQSALATALRALAPPGAPVLVESPTYPGMLAVARATGLRPVPVPMDGDGVRPELLADAFRATGARVFVTQPLFQNPTGVTLTPARRPEILAIARAAGAFVIEDDFARRLVHEDAGPLPAPLAADDPDGVVVHVCSLTKVTSPSLRVGALAARGPVLERLRAIQVVDSFFVPRPLQEAALEFVGSPSWGRHLAAVAAELRSRRTVMAAALRSELPALALPHVPAGGGSLWLRIPATGAGTGPDESAVASAALRASVAIAPGSPYFCAEPPAGHVRLSFAAVSGAAEIAEGVRRLRTAYDGLRPLGASGS
>NC_021177.1|WP_078618641.1|1259363_1260380_+|DMT-family-transporter
MRAQDSATAAGTIAVTIGTETSPTPGTGAPQHTVKAPARRGSLLAALGVVAFSLTFPSTAWGLESFGPWSLVALRSTLAAVIAGGFLLAVRAPVPARRHWGGLAVVAGGVVVGFPLLTTLALQTSTTSHAAVVVGLLPLTTAVLGSLRTGERPSRTFWAAALAGAAVVIGFTVQQSGGALAPGDLYLFGALLVCAAGYTEGGRLARVMPGWQVVGWALILCLPLAVAGSAVALPLEPVHLTAHGILGLVWVAAGSTFFGLYVWYKGMAEIGVPRASQLQLAQPLLTLAWSFLLLGEEVSAAAPLAAVAVLVCIAATQRTGRRDRAAQRAAGESAPVRS
>NC_021177.1|WP_015607461.1|1260430_1260634_+|DUF1918-domain-containing-protein
MEAHAGDRLLMHGRTVGQHDRVAEIIEVLGDGGAPPYRIRLPDGHEHLMSPGPDSVVQHVEAPRDQH
>NC_021177.1|WP_043971743.1|1260677_1261916_-|family-10-glycosylhydrolase
MASAAALVAAMTTGGDAVASQPARALRGGGDGEDRFARGELRGVWIATVANLDWPSRAGLTAAAQEAELIAHLDRAVALRLNAVVLQVRPTADALWPSPYEPWAACLTGAQGKDPGWDPLATAVREAHDRGLELHAWFNPYRVANHTDPTRLAASHPARLHPEWVLPYGGKLYYNPGLPEVRSFVQDAMLDAVRRYAIDAVHWDDYFYPYPVAGEAFKDDAAYERYGAGFSDRAAWRRDNTDRLVREMGERIRETRQGVRFGISPFAVWRNASTDPLGSDTRAGVETYDDLHADTRKWVKEGWIDYIAPQIYWHIGLAAADYAKVLAWWSATVRGTGVGLYVGEALYKAGDPAQPAPWQDPAELSRHLTLARDHEEVGGHIFFSAKHVAADRIGAMARVVADHYQDRVRAPR
>NC_021177.1|WP_015607463.1|1262144_1263005_+|3-hydroxybutyryl-CoA-dehydrogenase
MADIARVGVVGCGQMGAGIAEVCARSGLEVKVAETTGEALEIGRTRLHNSLSKAAERGKISAEERDETLGRLSFTTDLGEFADRDLVIEAVVENEQVKTEIFQVLDQVVTRQDAILASNTSSIPLVKLAVATSRPDRVIGIHFFNPAPVQKLVELIPALTTSDETIKRAEAVVQDVLGKHPIRAQDRSGFVVNALLIPYLLSAIRMFESGIASREDIDNGMEMGCAHPMGPLKLADLIGLDTVASVADSMYAEYKEPLYAAPPLLQRMVDAGRLGRKTGSGFYPYA

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Crispr_ID: NC_021177_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_2

2030850-2031015

Orphan

Consensus_repeat	Method
ATCCAGCCCGTCCGGCGATTGAGGAC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_021177_2

>merge|NC_021177|2|2030850-2031015|CRISPRCasFinder
ATCCAGCCCGTCCGGCGATTGAGGACACGCTCCCCAGTCCCACCCGCACCATCCAGCCGATCCGCACCACATCCAGCCCGTCCGGCGATTGAGGACGTCTTTCGCCCGCGCACCTGGCACGGGCATCGCCGGAGGCCCGCACCCAGCCCCTCCGGCGCTTGAGGAG

>NC_021177|2|2|2030850-2031015|CRISPRCasFinder
ATCCAGCCCGTCCGGCGATTGAGGAC	ACGCTCCCCAGTCCCACCCGCACCATCCAGCCGATCCGCACCAC
ATCCAGCCCGTCCGGCGATTGAGGAC	GTCTTTCGCCCGCGCACCTGGCACGGGCATCGCCGGAGGCCCGC
ACCCAGCCCCTCCGGCGCTTGAGGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015608132.1\|2021295_2022174_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226354
NC_021177.1\|WP_078618656.1\|2039543_2040167_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NC_021177.1\|WP_015608129.1\|2016268_2018005_-\|secreted-alpha-amylase	unknown	unknown	gnl\|CDD\|200456
NC_021177.1\|WP_015608144.1\|2037424_2038024_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NC_021177.1\|WP_043974289.1\|2035761_2037261_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_021177.1\|WP_099127865.1\|2025986_2026886_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|379588
NC_021177.1\|WP_106960199.1\|2038056_2039268_-\|twin-arginine-translocation-signal-domain-containing-protein	unknown	unknown	unknown
NC_021177.1\|WP_015608146.1\|2040102_2040867_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_021177.1\|WP_015608138.1\|2028565_2030035_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NC_021177.1\|WP_015608131.1\|2019508_2021185_-\|glycoside-hydrolase-family-13-protein	unknown	unknown	gnl\|CDD\|200471
NC_021177.1\|WP_015608141.1\|2034213_2034750_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|334450
NC_021177.1\|WP_015608134.1\|2023209_2024481_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270454
NC_021177.1\|WP_015608130.1\|2018462_2019524_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_021177.1\|WP_015608137.1\|2026940_2028542_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|224490
NC_021177.1\|WP_015608142.1\|2034721_2035534_-\|putative-protein-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|274733
NC_021177.1\|WP_015608133.1\|2022170_2023190_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_021177.1\|WP_015608148.1\|2041473_2041770_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227505
NC_021177.1\|WP_015608135.1\|2024842_2025910_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_021177.1\|WP_043971998.1\|2041024_2041363_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015608140.1\|2031048_2034045_-\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	unknown	unknown	gnl\|CDD\|237613

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015608132.1\|2021295_2022174_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226354	COG3833, MalG, ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism].	9.64145e-84
NC_021177.1\|WP_078618656.1\|2039543_2040167_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	7.51164e-19
NC_021177.1\|WP_015608129.1\|2016268_2018005_-\|secreted-alpha-amylase	gnl\|CDD\|200456	cd11317, AmyAc_bac_euk_AmyA, Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase). AmyA (EC 3.2.1.1) catalyzes the hydrolysis of alpha-(1,4) glycosidic linkages of glycogen, starch, related polysaccharides, and some oligosaccharides. This group includes AmyA proteins from bacteria, fungi, mammals, insects, mollusks, and nematodes. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	1.67231e-171
NC_021177.1\|WP_015608144.1\|2037424_2038024_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	2.16758e-18
NC_021177.1\|WP_043974289.1\|2035761_2037261_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.10287e-57
NC_021177.1\|WP_099127865.1\|2025986_2026886_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	1.04862e-47
NC_021177.1\|WP_015608148.1\|2041473_2041770_+\|hypothetical-protein	gnl\|CDD\|227505	COG5178, PRP8, U5 snRNP spliceosome subunit [RNA processing and modification].	1.1945e-05
NC_021177.1\|WP_015608146.1\|2040102_2040867_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.5614e-32
NC_021177.1\|WP_015608138.1\|2028565_2030035_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	3.80798e-34
NC_021177.1\|WP_015608131.1\|2019508_2021185_-\|glycoside-hydrolase-family-13-protein	gnl\|CDD\|200471	cd11332, AmyAc_OligoGlu_TS, Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomaltooligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. Trehalose synthase (EC 5.4.99.16) catalyzes the isomerization of maltose to produce trehalulose. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_021177.1\|WP_015608141.1\|2034213_2034750_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|334450	pfam01243, Putative_PNPOx, Pyridoxamine 5'-phosphate oxidase. Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as yeast YLR456W and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.	2.0679e-13
NC_021177.1\|WP_015608134.1\|2023209_2024481_-\|extracellular-solute-binding-protein	gnl\|CDD\|270454	cd14751, PBP2_GacH, The periplasmic-binding component of the putative oligosacchride ABC transporter GacHFG; possesses type 2 periplasmic binding fold. This group represents the periplasmic component GacH of an ABC import system. GacH is identified as a maltose/maltodextrin-binding protein with a low affinity for acarbose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.39972e-153
NC_021177.1\|WP_015608130.1\|2018462_2019524_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.98977e-91
NC_021177.1\|WP_015608137.1\|2026940_2028542_-\|amidohydrolase	gnl\|CDD\|224490	COG1574, COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only].	6.54205e-110
NC_021177.1\|WP_015608142.1\|2034721_2035534_-\|putative-protein-N(5)-glutamine-methyltransferase	gnl\|CDD\|274733	TIGR03704, PrmC_rel_meth, putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific. This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification].	2.34279e-119
NC_021177.1\|WP_015608133.1\|2022170_2023190_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.968e-92
NC_021177.1\|WP_015608135.1\|2024842_2025910_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	9.6144e-99
NC_021177.1\|WP_015608140.1\|2031048_2034045_-\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	gnl\|CDD\|237613	PRK14109, PRK14109, bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase.	0

>NC_021177.1|WP_015608138.1|2028565_2030035_-|APC-family-permease
MSAPTLRKGTLGTADIAFFVISAAAPLTVMAGVAPIALLLGGIGAPVGYLVAGITLAIFAVGFTTMSRHVRSAGAFYAYITRGLGKPVGIAAALIAMLGYNGMEIGVYGLLGSATADTAHALWGVDVPWLPVSLLGLLLIWYGGFRSIDFGAKLLGVLLLAETGILVLLAGGVLLDGGGDGGISFASFSPGNVFVPGMAAVLACAFAAFTGFESTVIYRREARSPERTVPRATYIAVAFLGLFYAFVVWSVIQAFGDAKVVQAAADNPGGLFFSAITTYVGPWAADLMHILIVTSVLASLLAFHNAINRYGLALAEEGVLPPVLGRVHPRHRSPYVAGAAQTVLGAVVVIGFAAAGADPYAQLLLWVNTPGMIGLMVLQLLAALAVFLFFRRAPHQEGALRTVVAPLVAAVLLTGAIGLVSYNVDLFTGASTGVNVLLVSLVPGVFLLGLLLARRLRRHRPEVYADFAAEPPEDSPGPSSKPVSTSVTL
>NC_021177.1|WP_015608137.1|2026940_2028542_-|amidohydrolase
MPAADLLITGARVRTLDPDRPEATAVAVAGGTIIGVGDADDLRELRGPGTEHLDLGGSATLTPGLTDAHSHPVWGLEMATGTDLTAVRDLEQLRAALAAASRTEGWVIGWGLDHNAFGDLPVSHTHIEEALGGAPAFLRLYDGHSALASAAALERAGITGPRTFAQRSEVVCDRDGRPTGHLVEHAAMDLLTPLLPRPSLAERRAGLVELLSAMAATGLTGAHVMDLGDGSVPGFLAAVEEDTDLPVRLRLAPWCMPGADKEALEELVRLQSEAGRLWRVGGVKFFMDGTVEGGTAWLEEADCHGQGTEAFWPDPAAYTEAVTHLHRAGVRTATHAIGDAAVRHVLDTVEGLGGSGRLRHRVEHIESVPHEVAERFVRLGVIASMQPTHTAYTRADHTDAWSRRLGDERAARAWRCRDLRDAGAYLALGSDWPIAHYDVRQVLATARLRRLPGAYDTEPVAPEQALTGLMALEGCTSHAAVAAGEQGVAGRIAPGFRADLTAFGVDPVQAPADELGEAPVRLTVTGGRVVHRG
>NC_021177.1|WP_099127865.1|2025986_2026886_+|phosphatase-PAP2-family-protein
MGETDVTAQEDGKTRWSDRFRSLRSPGRPRLWFEILLIGVSYWLYSLVRNAVPEQKAQALSNADWIWSAEKSLGLAFEETVNHAVNSVTWLVVSMNYYYATLHFVVTIGVLVWLFRRHPGRYAATRLVLFATTAVALLGYYLYPLAPPRLMNGANFIDTVLVHETWGSMASGNFKNMSNQYAAMPSMHIGWSLWCGLTIFALASAPWARILGLLYPTLTLVVIVATANHFWLDAVGGMACLAFGYAVSRVWYGSLPHHLPKWVPSKRGGRLKGVRAAARLPRPAAEPAAEPEAAGARRS
>NC_021177.1|WP_015608135.1|2024842_2025910_+|LacI-family-DNA-binding-transcriptional-regulator
MTARLADIATQAGVSEATVSRVLNGKPGVAATTRESVLAALDVLGYERPVRLRRRSAGLVGLITPELENPIFPALAQVIGQALTRQGYTPVLATQTPGGSTEDELTEMLVDRGVSGIIFVSGLHADTSADMQRYEQLRGQGVPFVLVNGFSAKVQAPFISPDDRAAMRLAVTHLVALGHTRIGLAVGPKRFVPVLRKIEGFHATMQEQLGLGPDEVEELIQHSLYTLEGGQAAASALMERGCTAVVCASDMMALGAIRAARRLSREVPRDLSVVGYDDSPLIAFTDPPLTTIRQPVTAMGQAAVRTLLEEIGGTPAPHSEFVFMPELVVRGTTASGPGTGSGAGPVGGSGSHPRP
>NC_021177.1|WP_015608134.1|2023209_2024481_-|extracellular-solute-binding-protein
MRRGITATALVAALALAATACGSDDKSGGGSSSGELSGTVTWWDTSNVGSEDKVFKKLAEGFEKKHPKVDVKYVSVPFGDAQNKFKNAAQAGSSAPDVIRSEVAWTPDFASLGYLAPLDGTAALKNQDDFLPQAVASTKFEDKTYAVPQVIDSMGIFYNKKLLEKAGVEAPTNLVELKTAAKQIKDKTGKTGLYLRGDDPYYFLSFLYGEGGDLVDAESKTVTVDKPEGVKAFKAVKALVDDGTAKTDASDGWENMMQSFKNGDVAMMINGPWAVADTLTGKEFTDKDNLGIATVPAGSTAHGAPQGGHNLAVYAGSKNLEASYAFVEYMTSVESQATTAGELNLLPTRTSAYAKKEAVNSEIVGFFKPVVETAVERPWIPEGGSLFAPLGVEYTKVLTGQTTPEKAAKSTGDSYRKLLEGWK
>NC_021177.1|WP_015608133.1|2022170_2023190_-|sugar-ABC-transporter-permease
MAVHTSQSVVKAAGENDARGRSRGTGTPPPAPGRFRRGLSTHWYAWTMVAPVVLVIGVIIGYPLLRGIYLSMTDADERNVARSIGVNELPATYKFVGADNYIDALTGSQFLGTLGWTLVWTVSCVSITFVLGMGLANILNRRIAGRSAYRMALILPWAIPGFVSVFAWRFLYNEERGLLNKILGGAGIDGIPWLNDPTWAKFAVIAVNVWLGIPFMMVALLGGLQSIPSEQYEAAEMDGATAWQRFRHITLPGLRPVSTTVILLSTIWTFNMFPVIFLLTRGGPGEATQILVTQAYKFSFEISPRDFAQSSTWGVLILVLLMLFAVIYRRVLRTQGDNW
>NC_021177.1|WP_015608132.1|2021295_2022174_-|sugar-ABC-transporter-permease
MSTVTDTSTRHAGPKVRLRGERSPLASIGLHLTLIIASVIAVFPVLWVLLTSLKPAKFATTTDFFRETTFVNYTNLIRDTEFLNWFANSAIIAGLSTLIGVFVAATTGYAVSRFRFPGKRGLMWTLLITQMFPVAVLIVPIYNIMANLGLLNQPAGLVITYLTISVPFCAWMMKGFFDTIPREIDESGEVDGLTPFGTFFRLILPLAKPGLAVTAFYSFITAWGEVAYASAFLVGDENLTLAGGLQKFVNQYGAQWGPMTAASVLIAIPAALVFLFAQKHLVTGMSAGAVKG
>NC_021177.1|WP_015608131.1|2019508_2021185_-|glycoside-hydrolase-family-13-protein
MTQHLAAPSTGTSDDAPGHRTGWWQDAVIYQVYPRSFADGNGDGMGDLAGVTARLPYLRDLGVDAVWLSPFYASPQADAGYDVADYRAIDPMFGTLLDADALIREAHGLGLRIIVDLVPNHSSDQHEWFKRALAEGPGSALRERYHFRPGKGTDGELPPNDWESIFGGPAWTRTVNPDGTPGDWYLHLFAPEQPDFNWEHPAVADEFRSILRFWLDMGVDGFRVDVAHGLVKAEGLPDLGAHDQLKLLGNDVMPFFDQDGVHEIYRSWRTILDEYPGERIAVAEAWTPTVERTANYVRPDEMHQAFNFQYLGTAWDAAELRKVIDISLDAMRPVGAPTTWVLSNHDVTRHATRFANPAGLGTQIRTPGDRELGLRRARAATLLMLALPGSAYVYQGEELGLPDVTDLPDEARQDPSFFRAEGQDGFRDGCRVPIPWNREGTSYGFGAGGSWLPQPAGWGELSVEAQTGVEGSTLELYRAAIAARREHPGLGAGADVEWLDGPEGVLVLGRPGFVCTVNTTGAPVRIAARGRVLLASAPVTVDGAEAVLPADTTVWWTV
>NC_021177.1|WP_015608130.1|2018462_2019524_-|LacI-family-DNA-binding-transcriptional-regulator
MVDGVTLPAPRTTAAPRLSDIAGQAAVSEATVSRVLNGKQGVADTTRQRVLAALDILGYERPVRLRQRSAGLIGLVTPELTNPIFPAFAQSVEQVLAGHGYTPVLCTQLPGGATEDELVEQLVERGVGGIVFLSGLHADTSADPARYAALAERGVPFVLINGYNERISAAFVSPDDNAAVRMAVGHLADLGHRRIGLAIGPQRYVPSRRKRDGFVEAAVSLLSMDRSEAEGLVCSTLFSVEGGQVAAGALLDAGCTGIVCGSDMMALGVVRAARGRGLDVPRDVSVVGFDDSQLIAFTDPPLTTVRQPVQAMAAAAVGALLEEIGGSPVQRTEYVFQPELVVRGSTAAVRTEG
>NC_021177.1|WP_015608129.1|2016268_2018005_-|secreted-alpha-amylase
MARRPLSAALALVAGAAAALVIPTGFGTASPAQAAAPGDKDVTAVLFEWKFASIAKACTDTLGPAGYGYVQVSPPQEHIQGGQWWTSYQPVSYKIAGRLGDRAAFSAMVNTCHSAGVKVVADSVINHMSAGNGAGTGGSSYTKYDYPGLYSVNDMNDCQAQITNYNDRGNVQNCELVGLADLDTGEEYVRGKIAGYLNDLLSLGVDGFRIDAAKHMPAADLANIKSRLTNPNVYWKHEAIYGAGEAVSPSEYLGSGDVQEFRYGRSLKQVFLNENLANLKNFGEGWGFMESGKSAVFVDNHDTERGGDTLNYKNGSAYTLANVFMLAWPYGSPDVHSGYEFSNHDAGPPGGGQVNACYADGWKCQHDWREVSSMVGFRNAARGQSVTNWWDNGGDQIAFGRGNKAYVAINHEGSSLTRTFQTSLPAGDYCDVQSGRGVTVNGSGQFTATLGGGTAVALHANARTCSGGGGPNPDPGPGNGQSGASFGVNATTQPGQNIYVTGDQAALGNWNPAGAPKLDPATYPVWKLDVNLPAGTSFAYKYVRKDGQGNVTWESGANRTATVPSSGKVTLTADVWRS
>NC_021177.1|WP_015608140.1|2031048_2034045_-|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase
MTTVPGRRSSTFTRLLRHGFTDPSAAERLLDLDDLASVRSDPVLLEALGATADPDLALRGLVRLVEAETVGERQVLLDTLVTAKPLRDRLLGVLGASEALGDHLARHPRDWQALVTYEAADLHPGVAEFERGLAEAVDPDSLRVAYRRCLLTLAARDVCGTTDLAQAAAELADLATATLRAALAIARTAAPEDAAQCRLAVVAMGKCGGHELNYVSDVDVIFVGEARDGVDENKAMQAATRLAAHMMRICSENTAEGTIWEVDANLRPEGRNGPLVRTLTSHLAYYQRWAKTWEFQALLKARAVAGDPELGQEYVDAVSPLVWQAADRENFVPDVQKMRRRVVDNIPADRIERELKLGPGGLRDVEFAVQLLQLVHGRSDASLHSGTTLEALRALAEGGYVGRADAAQLDEAYRFLRSMEHRIQLYRLRRTHLVPEDEADLRRLGRSLGMRTDPVAELNKAWRRHASVVRRLHEKIFYRPLLDAVAELAPAESRLSAKAAAIRLEALGYADPGAALRHLEALSSGVSRKAAIQRTLLPVLLGWFADSADPDAGLLGFRKVSDALGKTPWYLRLLRDEGAAAENLARVLSAGRLAPDLLMRAPEAVAILGDPEGLTPRTRAHLEQEVLAAVGRAAGAESAVAVVRGVRRRELFRTTAADIIGSYGTEDSPAEQDHGALVDRVGSAVTDLNAATIAGALRAAVREQWGDTLPTRFAVIGMGRFGGHELSYGSDADVLFVHRPREGVSDEEAARAANAVVGEMRRLLQLPTADPPLLIDADLRPEGKTGPMVRTLRSYEAYYRRWSLVWESQALLRAEHMAGDEELGRDFIELVDPLRYPAEGLGEDAVREIRRLKARMESERMPRGADPTLHAKLGRGGLSDVEWTVQLMQMQHGWAEPGLRTTRTREALAAACAAGLIPGEDAEMLDEAWVLATRVRNAVMLVRGRPGDTFPSDPREMTAVGRYLGYGPGHVGDMLDDYRRITRRARAVVEERFYGAAS
>NC_021177.1|WP_015608141.1|2034213_2034750_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MSTTDRSGPGRTPVTELDARYSSEGATARPWPETAALLGAAPLYWLSTVRPDGRPHVTPLIGVWSEGALHFCTGPEERKARNLAANPEVVLTTGTNDLDSGVDVVVEGRADRVTDHDRLTALAREWEAKYGSDWHFDVEDGSFTHGEAAQAHVFAVHPRTVFGFGKGDPFSQTCYRFA
>NC_021177.1|WP_015608142.1|2034721_2035534_-|putative-protein-N(5)-glutamine-methyltransferase
MPVHPVSSFSATVATLRRAGCVFAEDEASLLHEAAASPDELSLLVEHRVAGLPLEHVLGWAEFCGRRLTVDSGVFVPRRRTEFLVAQAAALAPRRAVVVDLCCGSGALGVALATALDRVELHACDVEPAAVRCARRNVGDLGQVYEGDLFDPLPAALRGRVDVLLANVPYVPTADVELLPAEARVHEPRVALDGGGDGLDVMRRVAAEAPGWLAPGGSLLVEASERQRDAAVEVLGRAGLTPRVVVCEELYATVVIGTAGQVTRSGSTSG
>NC_021177.1|WP_043974289.1|2035761_2037261_-|MFS-transporter
MDHRHVLRALSGLLIVLFVAMISTTVVSVALPQIIGSLDGTQSQYTWVVTATLLASTASTPIWGKLADLFSKKLLLQIAIGLFVVSSIACGFAQSTEQLIAFRAVQGLGMGALQVLVQVIIAAMISPKERGRYNGYLGGVMAVATVGGPLLGGFITDASWLGWRWCFFIAVPFTLLASVMLSRTLHLAEVRRPDTKVDYLGASLIAAGVSLLLLWVTFVGDDFDWVSWQSAVMVGGSVLILGAAVLVEARVKEPVVPLHVVRRRDPALAIVASLAVGMAMFGGAVFLGQYFQIGRGYSPTEAGLLTIPLMAGVLVSSTVAGRLVSKTGKVKPYIVTGVVVLALGFLGLSFIDHETPLVAVSLGMLGVGVGVGMSMQNLVLVLQNTVPLSEIGAASGAITFFRSLGGTMGVSVLGAVLAHQVANKIAHGLAELGIDPAASGSGGSTLNVAAMPPQVQEVVRAAYGDATGHIFLISACIAVVGVIASLFLTPTKLRDSVDL
>NC_021177.1|WP_015608144.1|2037424_2038024_+|TetR-family-transcriptional-regulator
MDSSTAGPGLRERKKEATRQAVHEATLRLTVEHGFDHVTVEAVADAAGISRRTFSNYFTNKEDALLYGEEQQIRALVRTVQGRPADEPAWPALRAAVAQFAERVAPPERDWAVRTRLAMRHPSLLARQLANHAALERDLAEAVAARPGPTSAPVRPIVLAAGFLSSLRIAMRMWIEEDLAREPAAVIDEILDEMGRGFG
>NC_021177.1|WP_106960199.1|2038056_2039268_-|twin-arginine-translocation-signal-domain-containing-protein
MTREEQAALLQAAQGGKWFDPENLKRWETEKLLPTPMWHALLAECYGRPAEEIVRAIVVSRRRRRLHRLIGEEAREEGSAVDRRKFLGVAAAATGMAGLPDIAEARHGINAGLSTSDGGGLAYLDGAFERHRGGYRGRPPSEALGQMKADLDLLRELLGRPHPAAVRKDLARTAAGITGLVAIIQHDRDDQRDAVGWFATAEQAARESGDRHMPACRHAMVPLNYGAPHAAATMAIRARAEAGRSPSAAGALAAAVTARSLASVGDREGALRAVADARAAAARLDSVQGADTWFGYAPQKHHVHLSQAFTLMGRTREAYVEQESALALTKSPSVMTRALIAVDRAVCVRADGDPATAADLAVSAWLQLPAAYRDGLVRSRVESLCRSLPGRPGSTLRDALTSR
>NC_021177.1|WP_078618656.1|2039543_2040167_+|ATP-binding-protein
MTHVNSQSFFLVRAPTSVAINRRRLRELISTWHVRQDDDSDMAMTTVVSELVTNAVSHGAGDMLKVVVRADIGRGRLTIEVHDDSPALPQRRTPCPDAESGRGMVLVEHLAIAYGAENTARGKRVWAELALPPRRTTGRRSLDPLRSAAAAIARRLPAFAWLRRRLTALSRRSRPSDPALTENRPSLRTGSRRRRSRTRSPSGCPGR
>NC_021177.1|WP_015608146.1|2040102_2040867_-|GntR-family-transcriptional-regulator
MPRDTPYLQVADKIRTRVLSGEWAVGDKLPSRARFAEEYGVGHSVAQRAMERLIIEGILEGRAGSGTYVRKARQRLRMVRSRLRQERSGSPFRAGLKDQGGDGTWECNSRARVPATEDIAARLAIEPGDLCVMTHYEFLADGQPAQLATSWEPMAITGGTEVLLPEMGPRGKIGVVARMRSINVNISTALEMPRPARATREQANFLNISVGDLVTQLERIYFDAEGRPVETADIIVPDIRWEIAYEIDVDDSRF
>NC_021177.1|WP_043971998.1|2041024_2041363_+|hypothetical-protein
MLTAAIGAEPRVADTEAGIRVEADLPTELTEAEHAAVLAALATADHFGHTLTRTAEFVWAEISREATVTTTDSPDAAYRDLLAHTTTCGSCRAGAICPTAAKLVRTWRETRG
>NC_021177.1|WP_015608148.1|2041473_2041770_+|hypothetical-protein
MIALSATDVRTCEACWNAPVTAARHTETGRDLLCEECAAGDYPRRVDLFPPLGIYGLPPRKVRPDSKHRGNPPQPPPNPGPPLPKPPPAPSPPGTPPV

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Crispr_ID: NC_021177_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_3

2058540-2058734

Orphan

Consensus_repeat	Method
GGTTCCGTCCTCAAACGCCGGACGGGCTG	CRISPRCasFinder
GGTTCCGTCCTCAAACGCCGGACGGGCTGG	PILER-CR

2 spacers

The CRISPR arrays of NC_021177_3

>merge|NC_021177|3|2058540-2058734|CRISPRCasFinder,PILER-CR
GCCTCTGTCCTCAAGCGCCGGACGGGCTGGGTGTGGCCCGACGGGTCCGCGGTCGACTTGGCTGCGGGCCCGCCCGGCGCAAGGGTTCCGTCCTCAAACGCCGGACGGGCTGGAGAGGGGGGACCGGCCTCGGGCCTACGAGAGTGACCGGGCACCCCGTTCGACGGTTCCGTCCTCAAACGCCGGACGGGCTGT

>NC_021177|3|3|2058540-2058733|CRISPRCasFinder
GCCTCTGTCCTCAAGCGCCGGACGGGCTG	GGTGTGGCCCGACGGGTCCGCGGTCGACTTGGCTGCGGGCCCGCCCGGCGCAAG
GGTTCCGTCCTCAAACGCCGGACGGGCTG	GAGAGGGGGGACCGGCCTCGGGCCTACGAGAGTGACCGGGCACCCCGTTCGAC
GGTTCCGTCCTCAAACGCCGGACGGGCTG

>NC_021177|3|1|2058543-2058734|PILER-CR
TCTGTCCTCAAGCGCCGGACGGGCTGGGTG	TGGCCCGACGGGTCCGCGGTCGACTTGGCTGCGGGCCCGCCCGGCGCAAGGGT
TCCGTCCTCAAACGCCGGACGGGCTGGAGA	GGGGGGACCGGCCTCGGGCCTACGAGAGTGACCGGGCACCCCGTTCGACGGT
TCCGTCCTCAAACGCCGGACGGGCTGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015608157.1\|2049864_2050524_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015608154.1\|2047406_2047712_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_003969536.1\|2050745_2052107_-\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|223252
NC_021177.1\|WP_015608174.1\|2074265_2074448_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015608162.1\|2055047_2056634_+\|multicopper-oxidase-family-protein	unknown	unknown	gnl\|CDD\|225043
NC_021177.1\|WP_015608167.1\|2062216_2063842_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NC_021177.1\|WP_015608168.1\|2064043_2064934_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|234723
NC_021177.1\|WP_106960202.1\|2048756_2049026_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015608158.1\|2052349_2053042_+\|DUF3105-domain-containing-protein	unknown	unknown	gnl\|CDD\|378632
NC_021177.1\|WP_015608166.1\|2061320_2062049_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NC_021177.1\|WP_032752989.1\|2060101_2061127_-\|membrane-protein	unknown	unknown	gnl\|CDD\|197318
NC_021177.1\|WP_015608161.1\|2054505_2054976_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_043974297.1\|2073014_2074037_-\|membrane-protein	unknown	unknown	gnl\|CDD\|378925
NC_021177.1\|WP_015608172.1\|2072197_2073001_+\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|100079
NC_021177.1\|WP_015608163.1\|2056755_2058510_+\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NC_021177.1\|WP_106960203.1\|2053095_2053740_+\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|367619
NC_021177.1\|WP_015608170.1\|2066157_2067024_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NC_021177.1\|WP_015608160.1\|2053993_2054419_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341390
NC_021177.1\|WP_015608171.1\|2070608_2072201_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|238206
NC_021177.1\|WP_015608169.1\|2065138_2066161_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015608171.1\|2070608_2072201_+\|recombinase-family-protein	gnl\|CDD\|238206	cd00338, Ser_Recombinase, Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.	4.98325e-31
NC_021177.1\|WP_015608162.1\|2055047_2056634_+\|multicopper-oxidase-family-protein	gnl\|CDD\|225043	COG2132, SufI, Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism].	7.02388e-89
NC_021177.1\|WP_015608167.1\|2062216_2063842_-\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	6.93629e-79
NC_021177.1\|WP_015608158.1\|2052349_2053042_+\|DUF3105-domain-containing-protein	gnl\|CDD\|378632	pfam11303, DUF3105, Protein of unknown function (DUF3105). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	4.41002e-55
NC_021177.1\|WP_003969536.1\|2050745_2052107_-\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	0
NC_021177.1\|WP_015608168.1\|2064043_2064934_+\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|234723	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed.	3.2279e-161
NC_021177.1\|WP_015608166.1\|2061320_2062049_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	1.68684e-13
NC_021177.1\|WP_032752989.1\|2060101_2061127_-\|membrane-protein	gnl\|CDD\|197318	cd09084, EEP-2, Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps, proteins.	8.61316e-28
NC_021177.1\|WP_043974297.1\|2073014_2074037_-\|membrane-protein	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	2.33182e-06
NC_021177.1\|WP_015608172.1\|2072197_2073001_+\|site-2-protease-family-protein	gnl\|CDD\|100079	cd06158, S2P-M50_like_1, Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with a minimal core protein and no PDZ domains.	2.15922e-44
NC_021177.1\|WP_015608163.1\|2056755_2058510_+\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NC_021177.1\|WP_106960203.1\|2053095_2053740_+\|DUF305-domain-containing-protein	gnl\|CDD\|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	1.97084e-44
NC_021177.1\|WP_015608170.1\|2066157_2067024_+\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	4.80481e-21
NC_021177.1\|WP_015608160.1\|2053993_2054419_+\|CBS-domain-containing-protein	gnl\|CDD\|341390	cd04622, CBS_pair_HRP1_like, CBS pair domain found in Hypoxic Response Protein 1 (HRP1) -like proteinds. Mycobacterium tuberculosis adapts to cellular stresses by upregulation of the dormancy survival regulon. Hypoxic response protein 1 (HRP1) is encoded by one of the most strongly upregulated genes in the dormancy survival regulon. HRP1 is a 'CBS-domain-only protein; however unlike other CBS containing proteins it does not appear to bind AMP. The biological function of the protein remains unclear, but is thought to contribute to the modulation of the host immune response. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	3.38165e-47
NC_021177.1\|WP_015608169.1\|2065138_2066161_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	3.09139e-131

>NC_021177.1|WP_015608163.1|2056755_2058510_+|NAD+-synthase
MPQLRLALNQIDATVGDLAGNSESIVHWTRHAAEQGAHLVAFPEMVLTGYPVEDLALRSSFVEASRQALRALAVRLDEEGFGELPVVVGYLDRSEHAAARYGQPSGSPRNAAAVLHRGGIALNFAKHHLPNYGVFDEFRYFVPGDSMPVVRVHGIDVALAICEDLWQDGGRVPAARSAGAGLLLSINASPYERDKDDTRLDLVRKRAQEAGCTTAYLAMIGGQDELVFDGDSIVVDKEGEVIARAPQFSEGSVILDLELPAADAVAPSGVVDDGLRIDHVVLSDRPLDAYEPELAGGYAERLDDDEEVYSALVVGLRAYAAKNGFSSVLLGLSGGIDSALCAAIACDAVGAQNVYGVSMPSKYSSDHSKGDAAELARRTGLNFRTVPIAPMFDAYMGSLELTGLAEENLQARLRGTTLMAISNQEGQIVLAPGNKSELAVGYSTLYGDAVGAYGPIKDVYKSSVFRLARWRNRAAEERGQTPPIPEASISKPPSAELRPGQVDTDSLPDYDVLDGILELYVDRDQGMDAIVAAGFDAELVAKTLRMVDTAEYKRRQYPPGTKISPKGFGKDRRLPITNRWRESS
>NC_021177.1|WP_015608162.1|2055047_2056634_+|multicopper-oxidase-family-protein
MPTQPTRRAVLGAALAVAGTGALTACSDGGGHGGAHSPGGAQDSGTYVSPGGKEVAAAEEARGSGPVREVSLTATRTRLDLGGGTTVASWAYGDRLPGREVRVNAGDTLDLTLANQLPQPTSMHWHGLALRNDMDGVPGLTQRDIAPGADFRYRFAVPHPGTYWFHPHSGVQQDRGLYAPLVVEDPKEPLAYDKEWVVVLDDWVDGVEGSTPDAVLKELSGGMGGGMDHGAHSMSGAEAEAAEAEDPDGGSPSRMMMGARSELLGGDAGDVAYPYYLVNGRVAEDPETFRARPGDRIRLRIINAGGDTAFRVALGGHRLTVTHTDGFPVRHAQGDAVLLGMGERYDVLVTAGDGVFPLVALAEGKKASALAVLRTGSGAAPGASVRPEELDGKLVEAGRLVPDPSVALAGRAPDRTIRMRLTGGMADYDWAFDGQPYDAKQRRPVEAGERVRVVFDNGTAMWHPLHLHGHTFALGGNAAGARKDTAIVLPHRSLTVEFDADNPGLWMVHCHNVYHAEAGMMTVLGYRG
>NC_021177.1|WP_015608161.1|2054505_2054976_+|hypothetical-protein
MASTAGGVRSGSRSVIFGQLLLLTALLFGIVTMHTVGHPAEHAPSPSAPVAAPGTTSGAMPVSAPAAMPAPEAASDRAHPSHGSPDHSPMSGMDPLSVCLAVLGAWGLALLGAWLSGLRADGRPLGTALGAGLLRVLRPNPPPPISVLDTVSVLRI
>NC_021177.1|WP_015608160.1|2053993_2054419_+|CBS-domain-containing-protein
MTTAKDIMHSGARWIPAHETLDRAAQLMREHNVGALPVSANGDSDRMVGIITDRDIVVGCVAKGHDPSKVTAGDLAQGTPRWIEAGADVNAVLEEMQNHRIRRLPVVENKKLVGMISEADLAQHLTEEQIAAWAEKVYSRS
>NC_021177.1|WP_106960203.1|2053095_2053740_+|DUF305-domain-containing-protein
MRWVAGGAVVLALLFAGAASLASARGDGEPGEPAADSADAGFARDMAVHHQQAVEMSFIVRDRTDDEDVRRLAYDIANTQANQRGMLLGWLDLWELPKVAPGGAGPMTWMGGEDGHGDHGAGHGGGGGAGLMPGMATKDELKRLGELNGEQAEVFYLQLMTDHHKGGVSMAGACVSRCSVPVEKRLAAGMVEGQQSELGLMRDMLAARGAKPRT
>NC_021177.1|WP_015608158.1|2052349_2053042_+|DUF3105-domain-containing-protein
MSFGPSDPRYAVPPQQPSGGARSTRNRAIAIGLSAAVVAGLAVFGTYMVLETSEAKENRAGSSSAQDGKQPGGDKGDTGGAIAGLKSWDAAELGRNHSAGDVDYPMTPPVGGDHNPSWLDCDGDVYEKAVPDVNAVHSLEHGAVWVTYSTKAADADVAKLAERVRSTPFTLMSPYADQEGAIVLSAWGKQVTVDSADDRRVDQFLAQYVQGPQTPEPGAPCTGGLATVPQ
>NC_021177.1|WP_003969536.1|2050745_2052107_-|type-I-glutamate--ammonia-ligase
MDKQQEFVLRTLEERDIRFVRLWFTDVLGFLKSVAVAPAELEQAFDEGIGFDGSAIEGFARVYESDMIAKPDPGTFQILPWRAEAPGTARMFCDILMPDGSPSFADPRYVLKRILAKTSDLGFTFYTHPEIEFFLLKNKPVDGTRPTPADSSGYFDHTPQNVGMDFRRQAITMLESMGISVEFSHHEGAPGQQEIDLRYADALSTADNIMTFRLVMKQVALEQGVQATFMPKPFSEYPGSGMHTHLSLFEGDRNAFYESGAEYQLSKVGRSFIAGLLTHAAEISAVTNQWVNSYKRIWGGSSRAAGAGGEAPSYICWGHNNRSALIRVPMYKPGKTGSARVEVRSIDSGANPYLTYAVLLAAGLKGIEEGYELPAGADDDVWALSDAERRAMGIEPLPQNLGEAISLMEKSELVAETLGEHVFDFFLRNKKQEWEEYRSEVTAFELKNLLPVL
>NC_021177.1|WP_015608157.1|2049864_2050524_-|hypothetical-protein
MQLPRDPSNVAYALVAAFPTRLAGDVKSVLAVMPEARLAPTMPFEVEVQGETVAIPSRIYYEEPSPDSERPPLAGTQQVIWHCLYSRHSDGRVRQRHLEQIVASGEPWVVPFVVQLAGEYVLEIIEAIGRGLPGLAVPGSAQRRLYGEFIARNPAFFARTERRVVSYWSCYYRWKYGAFGTYPGYVLLEAFRAAVVEQVGAQWPRHTRTLLADAGEGPV
>NC_021177.1|WP_106960202.1|2048756_2049026_-|hypothetical-protein
MEPDEALQLAVAFLARSQRDEEPPLAIDAERVRESNGLLIVPYNSVQYLASRDVGQQLLDCWPILVDLERGDVRFGTLDERYLWRTPST
>NC_021177.1|WP_015608154.1|2047406_2047712_-|hypothetical-protein
MGARYYGADSESGDRIDDPSEDALFMMISDLNGSDNTFLVVQPDENDPVWFSSVAVLDDGGYEIVRRDTTRNEREVTTSTSINDIARDLTIWMAARSISSR
>NC_021177.1|WP_032752989.1|2060101_2061127_-|membrane-protein
MVQAYGADTGNGSAEQPQAGGSRFRSLLGRAARDRGIWRRGIVLALCSVVLTLVMVVHAQIPNRVGNLGSLVETFLPWIALFIPLLLILALLRRSATALIALLLPAVVWLNIFGGLITDKSGTGGDLTVATHNVNAGNPDPAGTAQQVAGSGADVVALQELPGGQVSTYEKSLAARYPYHSVQGTVGLWSKYPLSNTRPVDIKMGWTRAMRSTVKAPQGEIAVYVAHLPSVRVKLHAGFTANQRDNSADALGEAIADEQVERVVLLGDLNGTMNDRSLNAVTSQMRSTQGAAGDGFGFSWPASFPMARIDQIMVKGVEPKSSWTLAATDSDHLPIAARVEL
>NC_021177.1|WP_015608166.1|2061320_2062049_-|TetR/AcrR-family-transcriptional-regulator
MRDQDDGEHDGGEHCGTRSGEQDRHDACAGAGGAARGDGAQDPEPRRGRPRSAAAERAILDAVITLLEAGEPLAGLSIERIARTAGVGKATIYRRWTGKEELFVDVVRDMEPVDPPVSGTEGLADLRVMLESLRTRGLAQRSSVLLHNIFAQMKSHPKLWDEYSGTVIAPRRELMLAAVRRAVAAGELRDDLDVELIDDLFVGPMLVRTVHRPDAPLPDDLADRIIAALVQGLAPAGSPARA
>NC_021177.1|WP_015608167.1|2062216_2063842_-|MFS-transporter
MSNPSPSAAASSGVAAAEPRIPEAIHRRRWWILTVLMFSLLIVVLDNSILNVAVKTIASPAPTGIGATQSELEWAINSYTLVFAGLLFTAGLLGDRIGRKKVLLFGILVFGIGSALAAMSASPGELITWRALMGFGAAFVMPATLAVLMNVFERDEQPKAIGIWAGSVGLGIAIGPITGGLLLEHFWWGSIFLVNVPVVVLALVAMAILVPDSRDPKPGKVDPVGVALSIVGLVLLVYGIIRGGELADFTDTTVLLSIVGGLLVLAGFVWHEKRSSHPAIDITYFRKPAFSAAVAAIALVFFALMGVTFFSAFYLQSVRGYSALQSGLLIVPLAAAQMIFAPRARLVVDRFGARAVCTVGMLLVAAGLASFALFDAGTPVWVMCLVFFVQGTGMAHIMPPVTVAVMQALPREKAGSGSAINNTFRQVGGALGIAVLGSVLSTVYRGDIEGHLSAVPAGVRDVAGESIEATLGVAEKLGPVAGKPLVAAANDAFISAMHVTALGSAAVALIGVVVVGLYLPGRTPATPAEPAARPAEEPVSR
>NC_021177.1|WP_015608168.1|2064043_2064934_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MSLSAAQNQSSPAGTTASAPDSSKALYGGKSTRRITIHDIAAATERGEKWPMLTAYDAMTASVFDEAGIPVMLVGDSMGNVHLGYETTVPVTMDEIAILSAAVVRGTKRALVVADLPFGSYQEGPVQALRNATRLIKESGVGAVKLEGGERSLEQIRLLVEAGIPVMAHIGLTPQSVNAMGYRVQGRGDEAAHRLLRDAKAVQDAGAFAVVLELVPEELATQVTQTLHIPTIGIGAGAGTDAQVLVYTDMVGLTGGKVPRFTKQYANMRKVLGDAAKEFAEEVVGGTFPAPEHTFH
>NC_021177.1|WP_015608169.1|2065138_2066161_+|ATP-binding-cassette-domain-containing-protein
MVDMERIDRNPRNGGNAVEVRGLVKHYGETKALDGVDLDVREGTVLGVLGPNGAGKTTLVRCLSTLITPDAGHAVVAGFDVVKQPRELRRRIGLTGQYASVDEKLSGWENLYMIGRLLDLPRKQARARADELLERFSLTDAAKRACMEYSGGMRRRLDLAASMIGSPSVLYLDEPTTGLDPRTRNEVWDEVQRMVAEGATVLLTTQYMEEAEQLAKELTVIDKGKIIARGGVDELKAKVGGRTLHIRPSDPAELAAMAQAIREAGLDGVAGAQAVPDEGLLYVPILSDQQLTAVIGLLGVRGFSLAHVATALPSLDEVFLAITGDKASTFSDAAPQEVAA
>NC_021177.1|WP_015608170.1|2066157_2067024_+|ABC-transporter-permease
MSSTTTTLTPAPAGSAGPAPSKAAVAEEGRIGLRANLRHIGALARRNLLQIKKDPESMFDVLLMPIVFIVLFVYVFGGSVGASLGGNRHDYVNYLVPGLMAMMGMNIAMAVGTGVNDDFRKGVMDRFRTMPIARSSVLIAKIVVELGRLMIATLILLTMGFALGMELNGSVFGLLGAVALAATFGAAIMWIFILLGLTMKTAQAVQGTAMLVLMPLQFGSSIFAPTQTMPGWLQAFTDYNPLSNLADAARALMQGKPVGDSVWWTLAWAAGITVVMAPLAVAKFRKKA
>NC_021177.1|WP_015608171.1|2070608_2072201_+|recombinase-family-protein
MPREPRALIVVRLSSETETSTSLERQAKECAAYCSQRGWQVVGMAEDFGSASRSTPCQRPQLSSWLGDRAPEFDIIVVWRLDRLVRKVGDLHDLIVWARDHGGKAIVSVTEPFDLTHPSGEAMASIIASFAQMESHAASERVTSMRQHLLVTPRWGGGSPPYGYRTYEKEKGRYLEVNPVTAPVVREAARRVMAGESINAICKDFENRDVPSPADSYGRRRVERDFVWHPVTLKKILSSPALCGFKTRNEPVPGKKYQRKVLVRDERGQPVRMADPIMDEEMWGKLQGALAAAAVSTSKPASPRTPFLGVIKCGGCGKNLQLHITKKKRKDGSERITSKIRCLSRIDSPACKGYVFIPVEEITGPVTRMILSAIGDKPVTKRVYIQGKETTERLAAVEASINYHVAQLLPGGIYDSEALRAKGEKALAGLRSEVEQLQALGENGQDRWEYVETGMTFAEQWQGKDPGSVTNDLVQAGITVECHPEERGGHVLRLPEDLRRRIAGAPGRPQHRVATVPPTRPSTTATTLST
>NC_021177.1|WP_015608172.1|2072197_2073001_+|site-2-protease-family-protein
MNTGTKATEWRVSPVFLSIVAITAVAGWAVWTGIAGATGFAVFLFVTGAWIVSLCLHEYAHARTALHSGDTSVGSKGYLTLNPLAYTHALLSIVLPVLFVVMGGIGLPGGAVYIERARIYGRWKHSLISAAGPLTNVAFAVVCTAPFWLDALDGVPPAFQYALAFLAMLQVTAAILNSLPIPGLDGYGVIEPWLSYRIRRQVEPIAPFGLIAVFAILWIPAVNIAFFDGIDALLGVLGVDDLQRYCGYDLYRFWKAFFGEQNPGCAV
>NC_021177.1|WP_043974297.1|2073014_2074037_-|membrane-protein
MRDAVTTRSALVMLGVLLLQLGFALSYMGAFHAPEPHKVPITLVAPPAVEREMVARLEALPGEPLQVTPVTDRAEARERLLDRRTDAALVVDPARRTDTLLVASAGGPSATTAATEILQEVARAQNRTILVRDLRAPSAGDSRGLSSFYLVLSWTIGGYLAASALNMAAGSKKPTLRRTLVRLTAMLPYGFVSGIGGAIIVGPVLDCLPGAFWELVGIGTLVVFASGAVGVALQSVAGTVGLGLTILIFTILGNPSSGGVYPSSLLPPFWSAIGQALPPGAGTTVVRNTVYFDGNATTGALWILGAWAFGGVVVAILAAALREGRRRRGPRTDKAPAAAV
>NC_021177.1|WP_015608174.1|2074265_2074448_-|hypothetical-protein
MPRLALYALVVCVLAVAAAVVSFVQGSLLGIIWVLIAGLSSNMVWFYVRKQRMEAAAEAN

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Crispr_ID: NC_021177_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_4

2260580-2260684

Orphan

Consensus_repeat	Method
TGCTCTGCCAATTGAGCTACAGGGGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_4

>merge|NC_021177|4|2260580-2260684|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGATCGCGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGCTGCTCTGCCAATTGAGCTACAGGGGAT

>NC_021177|4|4|2260580-2260684|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGAT	CGCGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGC
TGCTCTGCCAATTGAGCTACAGGGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015608334.1\|2260865_2261174_+\|secreted-protein	unknown	unknown	unknown
NC_021177.1\|WP_015608328.1\|2247936_2248341_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NC_021177.1\|WP_015608337.1\|2264569_2266498_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_021177.1\|WP_043972062.1\|2255928_2259528_-\|LamG-protein	unknown	unknown	gnl\|CDD\|379155
NC_021177.1\|WP_106960094.1\|2249172_2255805_-\|type-IV-secretion-protein-Rhs	unknown	unknown	gnl\|CDD\|274730
NC_021177.1\|WP_015608333.1\|2259950_2260184_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015608326.1\|2244552_2245815_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_021177.1\|WP_032753389.1\|2270803_2271412_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NC_021177.1\|WP_106960093.1\|2245935_2247756_+\|phosphodiester-glycosidase-family-protein	unknown	unknown	gnl\|CDD\|378342
NC_021177.1\|WP_015608336.1\|2262836_2264570_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_021177.1\|WP_015608323.1\|2241646_2243014_+\|acetyl-CoA-carboxylase	unknown	unknown	gnl\|CDD\|223895
NC_021177.1\|WP_015608325.1\|2243749_2244490_+\|3-oxoacyl-ACP-reductase-FabG	unknown	unknown	gnl\|CDD\|235500
NC_021177.1\|WP_015608338.1\|2266513_2267650_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NC_021177.1\|WP_015608329.1\|2248353_2248695_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_021177.1\|WP_106960095.1\|2271598_2273218_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_021177.1\|WP_015608339.1\|2267809_2269741_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NC_021177.1\|WP_043972061.1\|2243021_2243645_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_021177.1\|WP_015608343.1\|2273108_2274368_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NC_021177.1\|WP_015608335.1\|2261240_2262695_+\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|198375
NC_021177.1\|WP_015608340.1\|2269841_2270690_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015608328.1\|2247936_2248341_+\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	1.37808e-22
NC_021177.1\|WP_015608337.1\|2264569_2266498_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_021177.1\|WP_043972062.1\|2255928_2259528_-\|LamG-protein	gnl\|CDD\|379155	pfam13385, Laminin_G_3, Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	2.66116e-26
NC_021177.1\|WP_106960093.1\|2245935_2247756_+\|phosphodiester-glycosidase-family-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	3.33614e-18
NC_021177.1\|WP_015608326.1\|2244552_2245815_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.43808e-70
NC_021177.1\|WP_032753389.1\|2270803_2271412_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	2.36859e-16
NC_021177.1\|WP_015608336.1\|2262836_2264570_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	8.0515e-161
NC_021177.1\|WP_015608323.1\|2241646_2243014_+\|acetyl-CoA-carboxylase	gnl\|CDD\|223895	COG0825, AccA, Acetyl-CoA carboxylase alpha subunit [Lipid metabolism].	2.26043e-46
NC_021177.1\|WP_015608325.1\|2243749_2244490_+\|3-oxoacyl-ACP-reductase-FabG	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	5.78825e-89
NC_021177.1\|WP_015608338.1\|2266513_2267650_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	5.62588e-165
NC_021177.1\|WP_015608329.1\|2248353_2248695_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.56703e-21
NC_021177.1\|WP_106960095.1\|2271598_2273218_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	9.54212e-57
NC_021177.1\|WP_015608339.1\|2267809_2269741_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NC_021177.1\|WP_043972061.1\|2243021_2243645_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.91738e-10
NC_021177.1\|WP_106960094.1\|2249172_2255805_-\|type-IV-secretion-protein-Rhs	gnl\|CDD\|274730	TIGR03696, tRNA_nuclease_WapA, RHS repeat-associated core domain. This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.	2.13639e-14
NC_021177.1\|WP_015608343.1\|2273108_2274368_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	1.92144e-69
NC_021177.1\|WP_015608335.1\|2261240_2262695_+\|carbohydrate-kinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	4.04154e-117
NC_021177.1\|WP_015608340.1\|2269841_2270690_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	8.20969e-20

>NC_021177.1|WP_015608333.1|2259950_2260184_-|hypothetical-protein
MFPGAGGPLVFDQVKTHRRGRPHSARSRRTVCGREPCAYLAAYSSIQGLLEETAPLEPGGIAERASFTRALAPPKIP
>NC_021177.1|WP_043972062.1|2255928_2259528_-|LamG-protein
MLVLPTQESFADTDSAGSGELSEGGRALAEAVASGSRVEVVGERSERTTVFANPDGFTFTLEQSVVPVRVAKGGGGWQAPDATLERRPDGSVGPKAAAVGMEFSGGGDDPLVKLSKHQQSLELAWPTDLPVPRLDGPSAVYEDVLPDVDLMVTATPESFQQVLVVRTPEAAAAPELKKLSFRLRTNGLEVRTGASGNLTAVDGNGKTVFRAPPARMWDSAGAAAVDAPTSLAHGAARPAAGNQAVPGDAAEAAPSGSGIEPGQGDNVARIDVEVAKDALAVVPDADMLAKTDGKAFPLFIDPTVTWGESERTLLRSDGYESYGWGNGDDGQGKGVGKCGTWAGYYCGPGYVQRLYFEFSPAELKGKQVLGATFRVTEPWAFQCDPRWVDLVRTNNISSSTTWSSRPKNLDLMVDRHVSAGRGSLCDPDSPDAPIEFKDNPDETNENLTPTVRDFAAGKFSRLTLMLKANDEGDTAAWKRFKNDAVLSVDFVGLPAKPSGIGLVTGSGTVCETKESDPAIVSDPTPTLTATPQTASGGEKDAQLRVAMDVDKKAANGTWSNAITEMERPTSGYVGDNVKLSASSATLAEGTLYRYRSWTRSYYNGGKSQLPGPSNASTTGWCYFKVDPTAPKAPKIAFGATYTECTTNACAPGGAPGVKDAFTFSAATGDTNVAYQYRLSQDAAWSTERAGATVKETITPAKPGTFRLYVRAKDTVGRWGAQNLVDFLVAAGAGPVGRWRFDEADGVAKDAATADGADDATLAGGAVRDDRGRRGLLTHDSSGDPLANPVTDKGLSLNGTTGYAATGGPALETRSAYTVSAWARLDRTTGVGIVASQDGARYSPFILSYSKDVGRWFFGVKETEATAVGYFGIAAKNPPVVGVWTHLAGTYDPVTQEVVLYVNGVSQGKRTAKGAWQTSGALQIGRYKWADVHQYYFPGSIDEVAVWQRALLPDEVADEARVSTAPGFAATELIADWSPSRGSGSVIGDTTSGYRRDLTLTGGASLDGEELVLDGVDDAAVANVPLVDDTGSFTVTTLVSLDETKLAAKPVGYIGQVLGQRTADGSSWGLWYEVTGHRTVLDEETLEERQVPTGFWRFGRLNADGTSTSVVSDEEAAIDAPVRLTGIFDAQDATVSLRVGYVLNGEPKLFTAQAGSGEFALGKGVGGGTWKYFLPGRIAEVRVWAGAVASHEQAEFLTGD
>NC_021177.1|WP_106960094.1|2249172_2255805_-|type-IV-secretion-protein-Rhs
MAFGIGTSRRWRRASRRPESRLLVASLVLALAVPVGLAPVASAQPGGLGRPDLPEQRVSKVKEVTGPGAREARTRVAKDREANAAQARTAKEEQQVTWPAPASAKVTLEPAGRAEAKPGGLPLTVAPSRTRSDAQGSTDVKLTTLDRKATDRLGVTGVVLTAEAGREGRAEVGIDYSSFASAVGGGWSGRLRLVRLPDCALTTPEKTECRTQTPLDSRNDTKKRTVTAQITLAGSAAGKRSGGAASGRQVLALTATAAGAGESAKGAGDYSATALSESSSWQAGASSGSFTWSYALDLPAAAAGPSPSFGLSYDSGSVDGRTATTNNQGTSVGEGFSMTESYIERTYGSCDDDGHDDVSEQCWKYDNARLVLNGVSSRLVKDDTSGKWRLEGDDASQVTRSTGADNGDNDGEYWTVVKGDGTSYVFGRDKLDGAGTERTNSTWTVPVYGDDSGEPGYDAGGSFADRSVKQAWRWNLDYTVDTNNNAATYWYAAEANYYKKSEATKAGVAYTRGGYLKEVRYGLRKDALFTDDADAKVTFDYAERCTASDCSSLNEDTADNWPDVPFDAICAKDSDDCLAEGPAFFSRKRLTGVNTFSWSAAEKKYAPVDSWDFTQQYLDGGDIGDTSDQVLTLKSIKRTGLTGTAVTLDPVSFTYQMRPNRVDGTDDILPLTRPRMSTITSETGSITTVTLSSAECTRSQVVGAEEDSNTRSCYPQYWNINGASEASVDWFQKYRVLAVTVSDPAGQNDTVENEYAYSGAAWHYSDEPFTPKDERTWSDWRGYRQVTVYGGAKDAARSKTVSLYLQGMDGDKKKDGTTRAVTVPALTAPALGIPALKDAEQYAGELRQSVVYDGATPISATMNAPWSKETARQSVPGAGDQVARYVRTAASTSYTYLTVPKTWRSTGTASSFDDFGMARTTSDLGDLAKSGDETCTRLWYARNEAAGLTSLVSRTRTVAKACSVTEAALALPANRDTRGDVLSDTATVYDTGTVAGWTPDQKPTKGAGTWTGRATGYPATATGGERNPTGWQRQLATTYDALGRTLTVTDAQDNVSRTAYTPVAAGPLTKTVLTNAKGHTAVTFLDPRRALPERTYDNNQNKTEQAYDGLGRLTQVWAPDRIRGSQSPNSTFAYHLSRTEPSSVATSTLKADGETYNTTYTVYDALLRPLQTQSPTPLGGRLLTDTRYDSRGLEYETYADIFDSTSTPKGVYTRAEYGEAPRQNETVFDGAGRPTTTALYTFGVKRWTTSTSYTGDSTATTAVKGGSATRTITDARGREVEKREYAGQKPDDAAYGSTLGIPYTSTATTYTPDGLKDVITSAQDGSKWIYTYDLFGRKVSETDPDMGRSATEYDTLDRAVKVTDARDASIITGYDQLGRVESTWSKEKADANLLTSRVYDTLAKGQMTSSTRYTGGSSGVRYTKSVTAYDSLNRAVGTRITLPDSDPLVKAGVSATLDFTSHYRIDGTLQNGTEPAVGGLAKETVEHRYNALGQATSVTGATGYLRAVDYSALGQVQQLTLGTGGEGAKNVYVTNTYEEGTARLTRSHVTDQTHPYMLQDLKYTQDDAGNMTSISDGATLGGTGKADHQCFVYDARRRLTEAWTPQTADCATTGRTAAGITGAAPYWTSYTYTAAGQRDTETTHATSVNASTTTTAYEYGTATGQPHPLNRTTGAKAGAYVYDKSGNTTKRPGVQATQTLDWDSEGNLSRTTEPAVGSKPALDTGYLYDADGELLIRRAAGAGDTVLYLGATEVRLTVKGTAKSLSGTRYYSAAGRTLAVRTATAGTASTQLSFLTADHHGTSSLAIEAVTQAVTKRYSTPFGAPRGDQPTTTWPDDKAFLGKPADITTGLTHIGAREYDTGVGQFLSVDPVLSIEQHQSLNGYTYANQNPATNSDPTGLACYGGNHSASCNPTGQGGDAPAGCYAGNMSASCVGYSGDNMGTGGGGGSVSSGGSGGTASTSIGGTAGYGTSLTYIAGPKPVPVCFACMIGLAPVLGAAAGPVLEEAQLQNYCTSVPIDTVCNPQDAVLGGGSDGFRELALKWAFGKLEWRSGTYGEDSEIARQVMMTDATFEQRDVISSMYYNLGIVKGKVSKSITNEGISGQLKKDLKPLITGDHNLATVGLGSYTTDYEVLRASPQGLQVRMTVRNTMTISSLARPAVGYGTAREKFVQRWLDNDGIIAFEGAGRPYSMEVTFRTVIRRNGYRGLGS
>NC_021177.1|WP_015608329.1|2248353_2248695_+|STAS-domain-containing-protein
MAQVNRRTVGDVSIVALTGNITIGVGDVVLRGAVQDELNDGSTKILLDLKNVTTIDSSGIGELVSAYTTATNRGAKLKLVNLPPKIHDILAITQLITVFDVYDTEDEAVKSFA
>NC_021177.1|WP_015608328.1|2247936_2248341_+|ATP-binding-protein
MGGNAVQLPSGVVHIDEAETWAETLAETCGLGEDDRYRICLAVREAAANAVLHGNRLHPGKRVRLDWETQEGRVRVTVGDEGDGFTPPPPTGKVNLTPSGRGLVLIDHLTDSYTVARRDDPPGTDVVLVFDTTA
>NC_021177.1|WP_106960093.1|2245935_2247756_+|phosphodiester-glycosidase-family-protein
MRTETAVPHNPIPRPSRRVRVPAALAVTSVLLLGAGAPGQLPPMGDAVAVGTEPVGRMPLGPADVPTHTRPADVLAPGVTYRKFWQGEASDSWAVWVRDRHSGMETFGSIDLAGKLAADVNAAGFTARVDTFTVPASVDTDSRIVGYGVRVGRFAADRREDAVQTKQTLAAAGFTNSRILFTAEDGGASRGPWQVRVITVAPSARVTLKAVHGKDIQGSETVRQLAQASGALVAVNGSEFDISGPNNTGSGGFEGVPQGLYLQNNTLLSAPNNGRTALLLEGLKGRAAVDEISSETRITAPDGATRVIDGINRATGQVLGCGGVGNDYRRSGEDRVRTLQPWRNTNCVDPDEIVVFRPEWGAATPTPVRRDGTWTDPATGWQAQWYADDAEFADQSVDVVMDGNWVVKELRSRAGGSPIPPGGRVLQGIGAGADWLRAHSEVGKAFKPGSTVRGRDGRSVTTPTLSAVAGGTPALVRGGEVWMNPAANGMSQTSCVPAALGPGEKCRANNTLLQRHARTLAGVTAAGELLLVTIDGRDPALSVGATLPEAAEVMKWLGAEDAVGMGSGGDTTLVAKDTLYNRPVDDWGGPLRERPMSNAVVIVEKP
>NC_021177.1|WP_015608326.1|2244552_2245815_-|MFS-transporter
MTETSEPPVHRTRILADLTPLRSSPDYRRLWFGNTVSWIGQGMTALAVSLQVYDITGSAFSVGLIGFCSLVPLVVFGLYGGAVADTVDRRKLGLFSASGSFSLAVVLMAATFAGIENVGLLYAIVALQAVCFALNAPARSSMIARLLPPEQLPAANALSSMTSTTGALVGPMLGGLIVGWWGYRAAYTVDALTFTASLYAMWRLPSMLPDREEGARKRASVLDGLRFLAGRPNLRMTFLSDLCAMVLAHPRALFPVVAIVWYGGDARTTGMLVAAPALGALLGGVFSGWLGRVRLHGLAVLLAVGGWGAAIAVFGLTRHLWLGLLFLALAGCADTVSMVFRNTMLQSAVPDEMRGRLQGVFIVVVAGGPRLGDFLAGSVAHLTSPAVAVVGGGAACVVAVSLLALKWRGFARYDARDPQP
>NC_021177.1|WP_015608325.1|2243749_2244490_+|3-oxoacyl-ACP-reductase-FabG
MSQLAGKVALVTGGSRGIGAAIALRLAEEGADVALTYVSAADRAKEVVAEVEELGRKGLAIQADSADPEAVMRSVEEAAGTFGRLDILVNNAGIFPSGPVEDMTLSEIDRTLAINVRAVFLATQAAVLHMGHGGRVISIGSCWATRVPVPNVTLYAMSKSALTGFTKGLAHDLAPRGITANIVDPGPTVTDMNPEGTEVAEAERLRTAAKVMGAGADIAGAVAFLAGPDARWITGTSLAVDGGYTA
>NC_021177.1|WP_043972061.1|2243021_2243645_-|TetR/AcrR-family-transcriptional-regulator
MTGRGRPRAFDRGAALRGAMETFWEYGYEGAKLTDLTAAMGINSASLYNAFGSKEELFREAVALYGATAGSSTGRALREEPTARGAVEAMLRGNIAIFADPRTPSGCMIVLAATNCSQQNREVAEHLAGCRRAAVAELEACLERAVEEGELATGTDVRSVAAFYATVLHGLSVEARDGVPLERLSSTVDHAVALWDSLVGRAEIQQP
>NC_021177.1|WP_015608323.1|2241646_2243014_+|acetyl-CoA-carboxylase
MPAEPSLRMTARETIALLTGAAGLTEHRPPPRTLPPDGPLGWAGYDAARERAAERTGEDESVVYGTGVVGDRECVLLSFEFGFLGGSLGQLTGDRLEAAYGLALTRRLPLVALVATGGSRMQEGMVALTQLQRVAAASTRLRAAGLAQIAVVRDPTTGGGWATVGAGADVVLALPGAQVGFAGSRVRPPDADPYAYSAEGQFAAGQVDAVVPGAELPGTVALWLRALGAGGVGEEPRSAAPLPRARPSSASGLPASGREAVERARSSQRPRAEAYLADYFTVRLPLHGDRCGSTDPGLLTGFGLRADGQPVAYVAQCGTATRPAGYRAAARTIRLADRLGVPVLTLVDTPGAANDAEAERAGAGAAIADTFAAIAAARVPVTTLVIGEGGSGGALALAAPGNTHVTADSYFSVIAPELAAAILKRPPEETGATADQLRLRPQDLVELGIARSIVS
>NC_021177.1|WP_015608334.1|2260865_2261174_+|secreted-protein
MRYRLTFIAGVALGYVLGTRAGRERYEQLKKSARQFTENPAVRNAAESAAHSGRDFAGKAYHSVSDKVGDKVPASVAERVRSLRDRSSQNGGAEDDWGTTNT
>NC_021177.1|WP_015608335.1|2261240_2262695_+|carbohydrate-kinase
MGIVAGLDSSSAFTHIVVCDADSGAVLREGYAAHPVEAKAAEVDPQVWLLSLGEAASGGLLEGVQAIGVSAQQHGLVPLDRQGNLVRPALLGNDRRAQVAAADLVDALGGRQAWAEAVGAVPQAAQPVAKLRWLARTEPENAQRVAAVLQPHDWLVWQLLGRPARRTTDRGAASGTGYWSAGSAAYRPDLVELALGHPAALPEVLGPADSAGMTPEGLLISAGTGEIMAAAFGLGVAVGDAVVSLGASGSVMAVHHEALADPSGMITSFADATGMHLPVVHVSNAVRALRGTAEMLGLDGLEELSALALKSTPGASGLVLLPYLEGERTPQLPHTAGTLSGLRRESMKPEHLARASFEGMLCSLADALDVLRGRGVEVRRVFLLGAAAELPAVQALAPAVFGTQVVVPQPAQYAAIGAARQAAWALGVSQGTLDPRTPPAWQGAAAQVLEPGDELAVGRAVRQQYGATRDQLHPGAFGGAQQAE
>NC_021177.1|WP_015608336.1|2262836_2264570_+|ABC-transporter-ATP-binding-protein
MLIKLLRAHLAPYKKPIALLVFLQLLQTCATLYLPSLNADIIDNGVITGDTGYILEFGGLMIAVSVLQVLCNVGAVFYGARTASALGRDVRGAVFDRVQSFSARELGRFGAPSLITRTTNDVQQVQMLVLMAFTLMVSAPIMCVGGIIMALGQDVPLSAVLLAVVPVLGISVSLIVKKMRPLFRTMQERLDTVNRVLREQITGNRVIRAFVRDGYEEKRFRGANTELTDVSVATGRLMALMFPTVMTVVNLSSVAVVWFGAHRIDSGGMQIGALTAFLAYLMQIVMAVMMATFMFMMVPRAEVCAERIEEVLGTESSVVPPVSPVTELRRHGHLEVRGAEFRYPGAEEPVLRAVDLVARPGETTAIIGSTGSGKSTLLGLVPRLFDVTDGEVLVDGEDVRTLDPVLLAKTVSLVPQKPYLFSGTVSTNLRYGNPDATDEELWHALEVAQAKGFVEGLEHGLEAPIAQGGTNVSGGQRQRLAIARTLVQRPEIYLFDDSFSALDYATDAALRAALARETAGATVVIVAQRVSTIRDADRILVLDEGRVVGSGTHHELMDGNETYREIVLSQLTEAEAA
>NC_021177.1|WP_015608337.1|2264569_2266498_+|ABC-transporter-ATP-binding-protein
MAGPGGRMMAGGAPTERSMDFKGSSKRLLKRFGQEKASLYLMLGAVTVSVALSVAGPKILGKATDLIFAGVVGRQMREGTTKAEAIEGLRREGSGSMADMLSGVDFTPGEGIDFGAVGSVLLAVLVIYVGAGLLMLVSTRLSIRVINRIVFQLREDLQTKLSRLPLSYFDRAKRGEVLSRATNDIDNISQTLQQTMGQLINSLLTIVGVLIMMVWISPLLALVALVTIPLSVVVATQVGKRSQPQFVQQWRVTGKLNAHIEEMYTGHNLVKVFGRQEESAKDFAEQNDALYEAGFKAQFASGIMQPLMMFISNLNYVLVAVVGGLRVASGTLSIGDVQAFIQYSRQFSMPLTQVASMANLVQSGIASAERIFELLDAEEQGADPVDGERPKELLGRVSLEKVSFRYDPEKPLIEDLSLSVEPGQTVAIVGPTGAGKTTLVNLLMRFYEVTGGRIALDGVDVARMSRDDLRSRIGMVLQDTWLFGGSIAENIAYGAARAVTREEIEEAARAAHADRFIRTLPDGYDSVIDDEGSGVSAGEKQLITIARAFLSDPVILVLDEATSSVDTRTEVLIQKAMARLAHGRTSFVIAHRLSTIRDADVILVMENGSIVEQGTHEELLAAGGAYARLYAAQFAEALAEVD
>NC_021177.1|WP_015608338.1|2266513_2267650_-|RNA-polymerase-sigma-factor
MQTRTVTTTTEHMSAIPVQNRAVHHPENHPENDPGAAAGPPARAPEVVMSAPEAVMEEAEHVPEPREARGRTDNGGPTSDLFRQYLREIGRIPLLNAADEVELARRVEAGLFAEERLANTPDLDSRLAVDLDRLVVMGRTAKRRLIEANLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGYEPTAEEVAGQLDLTPERVTEVLRLAQEPVSLHAPVGEEDDVSFGDLIEDGDAASPVESAAFLLLREHLEAVLSTLGERERKVVQLRYGLEDGRPRTLEEIGRIFGVTRERIRQIESKTLSRLRDHAFADQLRGYLD
>NC_021177.1|WP_015608339.1|2267809_2269741_-|DNA-primase
MAGRINDDDVKAVRDAVPIDSVVSEYLQLRNAGGGNLKGLCPFHDEKSPSFQVSPGKGLFHCFGCQEGGDTIAFVMKIDHLSFSETVERLAAKAGITLRYEEGGYNPSHQRGERIRLIEAHQAAAEFYVHQLESPEAEIGRKFLAERGFDQDAATHFRVGYSPAGWDHLTRYLRGKGFSDKELITSGLSQDGRRGPIDRFRGRLMWPISDTAGEIVGFGARKLRDDDNGPKYLNTPETPVYKKSQVLYGIDLAKKDIAKASRAVVVEGYTDVMACHLAGVTTAIATCGTAFGNDHIKILRRLLMDNGSARVIFTFDGDSAGQKAALRAFEDDQKFAAETYIAIAPDNMDPCDLRLAKGDDAVRDLVEPRTPLFEFALRQIVGRYDLETPAGRAAALDEAAAVVAKIKTSSVQREVAVQLAGLVGILDQEFVVRRVAQLARWARDKGGDGRGDGRGGRGPGPQDRRGGASHQAVQAPTAPSGPALNLRSPAHRTERELLKLALQKPALVSPAFDAYGVDEFTAPPYAVVRQCIEEAGGVERGLGDNREYLVAVMDAAPNSTVRSLVTELAVEVFMHRTIDETYAGMQLVHVRLRAVDRRINEVQGNLARLGSNVAPDELAAAQNEVWVLQQYARLLQAQGADAL
>NC_021177.1|WP_015608340.1|2269841_2270690_-|methyltransferase-domain-containing-protein
MTHAHTHSHGRHGEADILDLDAQVLAGHITALTGWLPVQAPPRRIVDLGCGTGTGTFALLDRFPEAHITAVDTSAAHLQRLREKACARGAEGRVRTVQADLDAADWPDLGAPDLVWASASMHHMADPGRALRQVHGLLAPGGLFAVVELSGFPRFLPEGAPEDRPGLEERCHGASDRFHAEHVPHRGADWGPKLTGAGFTVEDERVITVNIDNTDGSRSEAVGAYALGSLQRLRHSVAEALTPEDLAALDRLLDTEGPGSVLRRDDLVVRTERSVWAARRTG
>NC_021177.1|WP_032753389.1|2270803_2271412_-|helix-turn-helix-transcriptional-regulator
MEQNNDELDGLVRKRIRALRVAQGWSLEELAGRANLSQSSLSRIENGQRRLALDQLVTLARALDTTLDQLVETASDDVIISPMIDGAHGLMRWPVKGDPGMTVVRQRMTEPPPDNPARMRAHPGREWLVVLSGTAVLMLGHRRFRVETNQAAEFPTMLPHAIGAEGGPCEILGIFDRDARRGHLRDTRRTGDDCAPDLPHTT
>NC_021177.1|WP_106960095.1|2271598_2273218_+|MFS-transporter
MILVAVSVALMAVIASVSGLNVAQTDLAVEFSASQSTVLWIINIYTLALAALLLPLGAIGDRIGRKPMLIAGLIVFGVASVLAGLAPTAGIMLAARVLSGVGAAMIMPITLAVITSTFPEAERGKAIGVWTGVAGGGGVIGMFLSALLVDVASWRWLFVLPVALVGVALALTLRSVPDSREHAGHSFDTVGALTSVVAVTGLIFALQEGPEKGWSAPVTLSALTVGVLAAAAFVARELSRREAALLDVRLFRERRLASGSVTLLVVFGVQAGIAVVLFPFLQAVLGWSGLLSTLALMPMAVLMMLTSGLAPRLAARIGARTTMATGIALGGAGLALMALFVSVGGGYLSILPGMLAMGLGMGLAMTPSTEAITASLPRERQGVASALNDVTREFGTALGVALLGALLSAGYRSAVDDRLSGIPRDAADTAREGVANAVEAAGGAGPHRQALLDAAQRSFVDGWQQAMWAGVAVMAALLLLVLLRGPKGQGPGAGAGAPTLREAVRAGSPAAPTDRPVPPGHAADLPGSAPGSSPSRPTR
>NC_021177.1|WP_015608343.1|2273108_2274368_-|FAD-dependent-oxidoreductase
MVDAHRTFVIVGAGLAGAKAAETLRAEGFTGRVILIGDERDHPYERPPLSKGYLGGKEERDSVFVHEAAWYAGADIELHLGQPVTVLDRYAKTVQLGDNTVIHYDKLLLATGSEPRRLDVPGTDLVGVHHLRRLAHADRLRNVLAALGRDNGHLVIAGGGWIGLEVAAAARGYGAEVTVVESEATPLHQVVGPELGQIFTELHSSHGVRFHFGARLTEIVGQDGMVLAARTDDGEEHPAHDVLAAIGAAPRSALAEAAGLEMAERAHGGGIAVDASLRTSDPHIYAAGDVAAVAHPLLGVRLRVEHWANALNSGPAAARAMLGQDVTYDRVPYFFSDQYDLGLEYSGWAPPGTYDEVIIRGDAGKREFIAFWLKDRRVLAGMNVNVWDVTETIQELIRAGQQHDPEALADPSVPLDSLL

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Crispr_ID: NC_021177_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_5

2934702-2934815

Orphan

Consensus_repeat	Method
GCGGTGGGTGGGGGGCGCGGGACGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_5

>merge|NC_021177|5|2934702-2934815|CRISPRCasFinder
GCGGTGGGTGGGGGGCGCGGGACGCCGAGTGGGGCTGGCGCGGTGGATGGGGCTGAGGCAGGGGTCGGTACGCCGGGCGGGGCCGGGGCGGTGGGTGGGAGGCGCGGGACGCCG

>NC_021177|5|5|2934702-2934815|CRISPRCasFinder
GCGGTGGGTGGGGGGCGCGGGACGCCG	AGTGGGGCTGGCGCGGTGGATGGGGCTGAGGCAGGGGTCGGTACGCCGGGCGGGGCCGGG
GCGGTGGGTGGGAGGCGCGGGACGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015608891.1\|2915912_2917274_+\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NC_021177.1\|WP_015608905.1\|2939722_2940514_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213187
NC_021177.1\|WP_015608907.1\|2946072_2946660_+\|DJ-1/PfpI-family-protein	unknown	unknown	gnl\|CDD\|153243
NC_021177.1\|WP_032759021.1\|2948237_2948684_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_078618861.1\|2931625_2932783_-\|CDP-glycerol-glycerophosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|367953
NC_021177.1\|WP_015608908.1\|2946708_2947386_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NC_021177.1\|WP_015608904.1\|2938779_2939730_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224596
NC_021177.1\|WP_015608897.1\|2926138_2929609_-\|bifunctional-glycosyltransferase-family-2-protein/CDP-glycerol:glycerophosphate-glycerophosphotransferase	unknown	unknown	gnl\|CDD\|367953
NC_021177.1\|WP_015608899.1\|2930753_2931518_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NC_021177.1\|WP_015608893.1\|2918752_2919631_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_021177.1\|WP_015608890.1\|2911753_2915611_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|274858
NC_021177.1\|WP_015608902.1\|2936769_2937993_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_032759038.1\|2917365_2918652_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NC_021177.1\|WP_032759089.1\|2938005_2938626_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NC_021177.1\|WP_015608911.1\|2948752_2951569_-\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_021177.1\|WP_015608896.1\|2923217_2926142_-\|CDP-glycerol:glycerophosphate-glycerophosphotransferase	unknown	unknown	gnl\|CDD\|367953
NC_021177.1\|WP_015608909.1\|2947454_2947961_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_032759092.1\|2929827_2930709_-\|methyltransferase	unknown	unknown	gnl\|CDD\|377550
NC_021177.1\|WP_015608895.1\|2922078_2923221_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340847
NC_021177.1\|WP_015608906.1\|2940640_2945623_-\|NAD-glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|377452

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015608891.1\|2915912_2917274_+\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	3.44971e-27
NC_021177.1\|WP_015608905.1\|2939722_2940514_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213187	cd03220, ABC_KpsT_Wzt, ATP-binding cassette component of polysaccharide transport system. The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2.	7.89921e-92
NC_021177.1\|WP_015608907.1\|2946072_2946660_+\|DJ-1/PfpI-family-protein	gnl\|CDD\|153243	cd03169, GATase1_PfpI_1, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	8.70603e-95
NC_021177.1\|WP_078618861.1\|2931625_2932783_-\|CDP-glycerol-glycerophosphotransferase-family-protein	gnl\|CDD\|367953	pfam04464, Glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase. Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerization of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate units from CDP-glycerol to the linkage unit lipid.	1.29086e-140
NC_021177.1\|WP_015608908.1\|2946708_2947386_-\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	1.32809e-24
NC_021177.1\|WP_015608904.1\|2938779_2939730_+\|ABC-transporter-permease	gnl\|CDD\|224596	COG1682, TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	8.93884e-42
NC_021177.1\|WP_015608899.1\|2930753_2931518_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	3.44155e-10
NC_021177.1\|WP_015608893.1\|2918752_2919631_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.82743e-73
NC_021177.1\|WP_015608890.1\|2911753_2915611_+\|FHA-domain-containing-protein	gnl\|CDD\|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	1.5098e-25
NC_021177.1\|WP_015608897.1\|2926138_2929609_-\|bifunctional-glycosyltransferase-family-2-protein/CDP-glycerol:glycerophosphate-glycerophosphotransferase	gnl\|CDD\|367953	pfam04464, Glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase. Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerization of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate units from CDP-glycerol to the linkage unit lipid.	5.41173e-105
NC_021177.1\|WP_032759038.1\|2917365_2918652_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.7507e-38
NC_021177.1\|WP_032759089.1\|2938005_2938626_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	8.16471e-22
NC_021177.1\|WP_015608911.1\|2948752_2951569_-\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_021177.1\|WP_015608896.1\|2923217_2926142_-\|CDP-glycerol:glycerophosphate-glycerophosphotransferase	gnl\|CDD\|367953	pfam04464, Glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase. Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerization of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate units from CDP-glycerol to the linkage unit lipid.	1.36442e-99
NC_021177.1\|WP_032759092.1\|2929827_2930709_-\|methyltransferase	gnl\|CDD\|377550	pfam05711, TylF, Macrocin-O-methyltransferase (TylF). This family consists of bacterial macrocin O-methyltransferase (TylF) proteins. TylF is responsible for the methylation of macrocin to produce tylosin. Tylosin is a macrolide antibiotic used in veterinary medicine to treat infections caused by Gram-positive bacteria and as an animal growth promoter in the swine industry. It is produced by several Streptomyces species. As with other macrolides, the antibiotic activity of tylosin is due to the inhibition of protein biosynthesis by a mechanism that involves the binding of tylosin to the ribosome, preventing the formation of the mRNA-aminoacyl-tRNA-ribosome complex. The structure of one representative sequence from this family, NovP, shows it to be an S-adenosyl-l-methionine-dependent O-methyltransferase that catalyzes the penultimate step in the biosynthesis of the aminocoumarin antibiotic novobiocin. Specifically, it methylates at 4-OH of the noviose moiety, and the resultant methoxy group is important for the potency of the mature antibiotic. It is likely that the key structural features of NovP are common to the rest of the family and include: a helical 'lid' region that gates access to the co-substrate binding pocket and an active centre that contains a 3-Asp putative metal binding site. A further conserved Asp probably acts as the general base that initiates the reaction by de-protonating the 4-OH group of the noviose unit.	3.43295e-43
NC_021177.1\|WP_015608895.1\|2922078_2923221_-\|glycosyltransferase	gnl\|CDD\|340847	cd03820, GT4_AmsD-like, amylovoran biosynthesis glycosyltransferase AmsD and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.	3.0953e-78
NC_021177.1\|WP_015608906.1\|2940640_2945623_-\|NAD-glutamate-dehydrogenase	gnl\|CDD\|377452	pfam05088, Bac_GDH, Bacterial NAD-glutamate dehydrogenase. This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyze the reversible oxidative deamination of glutamate to ketoglutarate and ammonia.	0

>NC_021177.1|WP_078618861.1|2931625_2932783_-|CDP-glycerol-glycerophosphotransferase-family-protein
MRAAYRTDLYRPLDPNLAVYGAYWNRGVACNPAAIHAKALELAPDIRGLWVVSSRYRDGMPAGVPYVIEGSRPYWRAMATATYLVNNSSFPGGFTKRPGQRYLQTHHGTPLKTMGLDQRAYPALARKADFAKILAHVGQWDFSLSANPHTTEVWDRVYPGPYERLDLGYPRNDVYFTATAEDIAKIRAGLGIAEGQTALLYAPTHRDYREGFLPDLDPERLARELGPEYVLLVRAHYFYGRSAGAAGTVDGRVLDVTAHPRVEELCLAADALITDYSSLTFDYACLDRPVVVHAPDWAAYRGARGTYFDLLSGRPGDTPGPVTTTSDELVEAFRTGEWRSPASAALRTAFRERFCPYDDGHAAERVVRRFFGLPHSGLPYFGTPH
>NC_021177.1|WP_015608899.1|2930753_2931518_-|class-I-SAM-dependent-methyltransferase
MHRSAYEQMELCIREYLPAEGPASGTYRVVDLGSRISGKQTRTHRALLAGHPIDYFGVDVQDGPNVDAVMKKPYRIPARSNSADVVLSGQAFEHIPFFWASMLEIARVLKPGGHAFITAPSRGHVHDAQDCWRYYPDGFRALAAHSRLELREAYTDFPPQKGIWHDYRAIDRKAAYWGDSVGVFRKPQGYPRLTMFAVRELAVWWANRVGGVDGVPLPEPLDGREQCGRPRSVPAQTSESAPALEQNPPRSMAG
>NC_021177.1|WP_032759092.1|2929827_2930709_-|methyltransferase
MAWRNAVNGVLQQLTGYQLRRVTVPAARTAPAESLAASTPAPAPPKPEAEEGQAKKPETKKSPAKKPSPAFPEDYDDEARDIIRAVKPYSMTSPERLNAFILATRYIARHNIPGDIVECGVWRGGSMQACARTLLSVGETERELYLFDTYEGMTEPTAEDLRRDGRPAQELLDAQGKDRPIWAVASLDDVKAGFENVPYPKERVHYVQGRVEDTVPGQAPEQISILRLDTDWYASTKHELEHLYSRLVSGGVLLIDDYGYWQGSRQAVDEFLDKTGERLLLLRMDEGRIAVKP
>NC_021177.1|WP_015608897.1|2926138_2929609_-|bifunctional-glycosyltransferase-family-2-protein/CDP-glycerol:glycerophosphate-glycerophosphotransferase
MAPRLTVVVPLYNVEEYLGVCLTSLAEQTMADLEVVLVDDGSTDNGPALAQEFVDRDPRFRLIRQENAGLGAARNAGVREADPAAEFLTFVDSDDVVPPGAYERMLAELDGSGSDFATGNVLRLRANGALEQSPMFRKPMEKARPATHVTRDWILLGDRIACNKVFRRTFWDEHSFAFPTGVLYEDIAVVLPAHFLARSVDVVEEPVYHWRDRDGSITTRRAVPQGIRDRVTAVTTVSDFLAGREGMAEAKRRYDAHALSGDLWLFIEALPGGDEEFHEAFLDHAGAFAATVAPEVFAGLPLDLRVKWQLIRERRIAELLALLGEEKNDRDAFHVRGLLRPRAHHPAVRDPLPPAATALTPADLPVHAHLTEAVWRDGLLRLTGYAYVRNAPGGPPRLGWLRSGKRMVPLRLRPTGGSGRDEATARSGRSLHRYARAGFEAVIDPRAIAARGKGPRTTWKLESLLFGAGRVRRGPMRLTGTPAPPAVLYTDERTRVVPVLSGNKLELRTERVPAVLTGHSAADDSLHLDVKVLDDDGPVALRLTEWRTKDTQEFALRGSLGSRAADIPLSAFRGKDEIWGVQLVGGRGRLTVAAPADAEDGRYPLPGGRELYVGPNPSGDVVLTDRAVQPVVTSVAWSEGGELVLEGAFPEPSGVIGELVARHSGHHEEAVIAVELGEGGVFRAVVDPAAVDGPGGPLPLAEGRWYLFLREPGERDPDAYRPLRLTTPLHAGLPLQRDAEGRPFTLQRRHHDRLVLESGSALPVTEQGPYGQRIQRERYAGLRATDRDHLRPAVLYASYDGRQYSDSPRAIHRELASRAPEIEHLWVVRDQQAAVPEGVRAIALHSAEWYEALARSRWVVTNTHLPQWFERAEGQCVVQTWHGTPLKRIGRDLAGTPHADAAYMASMERRSAQWSVLVSPNSFSTPVLRRAFGYSGEVLECGYPRNDLLYAPDRAKIATAVRERLAIPEGRRVVLYAPTWREDRPRHGGRYELDLQLDLDQAREALGEDHVLLVRRHYLVGGSVPGTDFVRDVSRHPDVSELLLISDVLVTDYSSIMFDFAQTGRPMLFHTYDLAHYRDTLRGFCFDFEHRAPGPLIPGSAEVVAALRDPEAAVAGHREAYERFREAFCDLDDGSAAAQVVDRMLKDGSGPREAQA
>NC_021177.1|WP_015608896.1|2923217_2926142_-|CDP-glycerol:glycerophosphate-glycerophosphotransferase
MTDFSCVITGGGETEGAGGADALRASVASVLGQSLQGCEALVVLASGAGAATRTAARALADSEPGRVRLVHADPAARTTGALRNAGLDAATGRYVLVLTPGERLHRHACRNLWQAGERSRADLVAGRWSRTADEGGKEQEPPWQDELFVRSRTVTRFAEAPGLVVRDALVTGFCLRREAVRRHGLRYEEDLAHGEILFGPLAAAAVGRIALVRRLIVTGRAVPDRARDLTALVEAHRRVANTLDAHGLPELREERELAFARDHLVPLARSFPRLPAARRTRTAATAARVLTAPVPQGLPPLERVAVALLARGDAEGVLTAAYALSRPATICAPLTTGPDGRVCWGGEGGEGSAEGAVAVDVTELGHQYRVFGEARLMNRLTRCTAEEGRLLLAGRLVLPPHTGPGPDTPLTATLEFRARGGARAVAFPVTELRHDGNGITWGARADVTRLLRPLGIRDTAWDARLIVEADGELGRVRSVSDLFGPQDLVEGAVRFAARPRLGRLTGETWEPYITLKDHLALRLTARRRPARTAHRLVRYATHFRPARKAKLLVRALRKRLDRYRSRGFKASLYNTWLTRLPVRRGSVVFESHMGRCYGDSPRALHEEIRRQGLKLRPTWSYDTSPAGFPDDARLVRRWSWRYVWALARAEYWVDNQGFPQNLRKPARTTYLQTWHGSAYKRMGFDERRVQLQNAPQRDRLQQAVHRFDHFLVRSEHDEVTLAHAYRLPEDRLLRTGYPRNDALIAERTRAETEGGLPRPPLAGELGIDDHKKVVLYAPTFRGGPAGGKQARRRLLLDVREFAERFGDTYTLLVRAHYLEAARLPVCPPGTVIDVSRHHDVSEILALADVLVTDYSSIMFDFALLDRPVVLYAPDLDAYAAERGSYFDLRESAPGPVTATQEELFAELAELKKSDTRHAAQRASFAEKFGAYDQGDAARQVVAAVFSRQGAGQGAGQGARRGVRHTTDHDRGAGR
>NC_021177.1|WP_015608895.1|2922078_2923221_-|glycosyltransferase
MSRDIFIVSNSTDELGGVTAWTHQTARLFTEQGHRVHIIGIHAAERKMALPESPRHPVTALYPAHPPTPWAAQGIRDRFRIPSRRREAARVAEKRRAVARLSELFAAARPGGVVVVSQVWAMEWVGEADTAGLRVIGMSHESYDYSRASHRYRWIKNHYKDIDHWLVLTEEDADRWAGDGMNNVGFLPNALAHLPHVPSPRTARTVASIGRLTDQKGIDLLLDTWALVAPQRPDWRLRVYGTGEDEAALKARCTGLGLDGSVEWMGRTDDVEGALAAASVFVQSSRGEGFPLALLEAMAGGVPCAAFDCAPGVREIVRDGEDGLLAPAGDTAALADRLLRLTGNPRLRDALGDRARSGVQRFSEPEVARRWEELFAFLER
>NC_021177.1|WP_015608893.1|2918752_2919631_+|carbohydrate-ABC-transporter-permease
MTTPSALKPKQSLGARIAARLGGGVMRVFLILVALFWIMPTIGLFLSSLRAPEDIAATGWWKIFTAPSELTFDNYQRLLDNSTITGSLVSTVMITVPSTVLVVVIGSLAAYAFAWMDFPGRDWWFLLVVGLLVVPVQVALIPVSELFGTIGIFETTLGVVLFHTAFGLPFAIFLLRNFFAQIPRELLEAARLDGAGEIRLFTRVVMPLGGPAIASLGIFQFLWVWNDMLVALIFAGSDSPPITVALQQQVRQFGNNIDVLAPGAFVSMVIPLAVFFAFQRQFVSGVMAGAVK
>NC_021177.1|WP_032759038.1|2917365_2918652_+|sugar-ABC-transporter-permease
MTGTRRVIAAAFLLPALVLLGALVLYPIGYSVYRSFFDQAGTGFAGIDNYKALFTDDTILTAVKNNAIWVVFAPTVATALGLIFAVLTERIRWGTAFKLIVFMPMAISMLAAGIIFRLVYDQAPERGVANAVAVSVHDTFNESAGFPKARPLPVHPLEKGEGGSFVSKEPVRAGEAVQVPLVGVAPAKMPGDARPAKAAPEADGGGITGTAWLDFTRGGGGKPNVVDPEELGLKGLKVEAVRDGKVIATATAGADGVFTLPASADGAQLRLPAENFREPYNGVDWLGPSLVTPGIIGSYVWMWAGFAMVLIAAGLAGLPRELLEAARVDGANEWQVFRRITVPMLAPVLAVVLVTLMINVLKVFDLVFIIAPGSSQDDANVLALQLYRSSFGTDADLGIGSAIAVLLLLLVVPVMLFNIRRIRKEAQR
>NC_021177.1|WP_015608891.1|2915912_2917274_+|carbohydrate-ABC-transporter-substrate-binding-protein
MRTTLSIRRAALVFTAVGALALTGCGDGGGSKKSGDGSGEGTDSASTVTLPKLDGENISVAAVWTGPEQANFTKVLGEFEKRTGAKVTFVPAQDPIVNFLGTKIAGGQPPDVAMIPQVGAIQQAVAKKWAKPVGPEARAQLGQNYAKVWQDLGAVDGTQYGVYFKAANKSLIWYNAAAFDNAGAAEPKTWKDFITTAETISASGVTPVSVAGADGWTLTDWFENVYLSQAGPEKYDQLAKHEIPWTDPSVKDALTTLAELFGKPELIAGGADGALQTEFPTSVTQTFTGGDQPKGAMVFEGDFVSVNIAQTEAKIGTDAKVFPFPAVGADSPVVTGGDAAVALKDSKGAQALLTWLASADAAKIWAEAGGFISPNKALDVAAYPNDVQRTMAEALVAAGDDVRFDMSDQAPQSFGGTPGKGEWKILQDFLKNPKDVAGAQQKLESEAAKAYKS
>NC_021177.1|WP_015608890.1|2911753_2915611_+|FHA-domain-containing-protein
MQIRLTVLAPRSGQTPARACDVLVTAPAGTALAAVASGLAQAVSGPEGSQGGGAVVLFAGRERLDAQRIALGEPPLVDGAVLSLQVPGEDEATDDAVPAQLHVVAGPDAGGVHLLHGGRIRIGRSAEADVPLDDPDVSRLHCAVTVSEDGRVSVADLGSTNGTSLDGAEVRDQPVRFPPGALLRLGESALRLTAGSRPVTLPAAPDGEGHLRVSRLDPDQHAPAHHTSGTPTAPPLRAYHYGSDDDGQSPAYGQQPHAFRQEPTGYEGQEPGPGHGTPDTSAHQHTHGGREPFGPAGGGEQFGAAGSWEQSGATGGREPFGAAGGRDSSGAGEAPRRGGIGAWARRLKGGGGARGEQAQGADQPGRDPWPGATAVPSGHSHDYSAEAQGADPYGTFGDPGHLASPASPLSPFSAVPSAPEGTWPDPAAVLLTALGPGPRLWERHDGHPEALVVRLGTTDRADVESVPVTVGLREAGSLGLAGPRARLAGLARATVAQLAALHSPFDLEIVLISTDRSRPLEERRREWSWLGWLPHLRPMHGQDCRLLLAYDREQAAARTAELVRRLDEGPFGPGWPNLDRTEVAEAARAHTGPHTVVVLDGDPGTAALRETTARLAGAGAAAGIHLICLAETPASSPTSPVAATYDAACRASIAFRECGAVAMLSGDVATALRLLRTAGGQAAGHGTVAAVDAVSAAWAERFGRALAPLRDEGSAALTGRPTTAALPPSARLLDELGLARATPASLMARWASTAEDQPGASVPRATAAVPPSRADLETPGSGRTLSTGPRVGPQRTAAEGHRSQDTPAPGRTPYPAAGDRDSSRTPYPGGGADSRDSGRTPYPPAETHGSGRTPYPGTDARDSNRTPYPGTDARDSSHTPYPGTDSRGSNRTPYPGTDARDSSRTPYPARTAPRVGPQGGEGSAQAGQHAGRPVLVLGAGPRGALSVDLADEGPHLLIEGPAGSGRTELLRAIAASLASAARPDRLGILLVDGAGGKPEDRDSSAPGLLPCTELPHVFTHLVASDPVRMREFAQALGGELKRRAELLGPLDFTSWHARHAEQAQQEESRRIVGQRPPTGAERRGDLDSPASGTLRLRPVAARASDPGPSPLPRLVVLVDDFDALVAPGLGSPGRPAAGSVVRALEAVARDGGRLGVHLVATSARPDRTEDTELARGARLRIVLDAPVLPPSPDEPAPGRGRLGHPDGRVTPFQGGRVTGRIPRTATLRPTVVPLEWERMGDPPTRRPVRELGNGPTDLALLASALERAARSVNAERLPPLIPFPT
>NC_021177.1|WP_015608902.1|2936769_2937993_+|hypothetical-protein
MPLSSATPAPSDAPPPAPPPRAADDDELVVAPRWLPSPYVLLGGLLWAVLSAAAWQVPMCCEAGLNAAVVERLRSNLLHPSFPMTDLPAVASAHYSPYAVLQGLTARAGGLSGQFVLVLSAAVNLALLLTGIGRLARLLTPNRWVPVLALIPLALIHWADPGRWSAPSTFAVAVTLHLWAWTGSAVTRVPRPGSGRPPGRAPRWAEAAGIGVLLGLVLLVHPPSALGAALGVVALIAVRQRTRIRPTVRRWAVAGLCAAAVAAVWPYYNGLTAQPAPSSAGATSRPETGGAPVTGEPYTWATAHVPPGEVVLTDSRPAMYALAGHGAYVLADGLPDAGLAAAERRARSRAVAAYLDSATTQEQRDRITGRYGVRWVLLTRFQKLPGDAAVLAYSPRTGEVLARVPER
>NC_021177.1|WP_032759089.1|2938005_2938626_-|TetR/AcrR-family-transcriptional-regulator
MIRAMTTERGTRRRAPAGAAVLREDVTDAIRAAVFEELAAVGFARMSIEGIARRAGVGKTAVYRRWKSKLALVLDLVAAVAVQGMPAPATGSLYGDVRAVLELAAYALRHPVASQVIPDLLVEAARNPEISEAIKAALLDQQQGVAAVVVREAVARGELPEGSDPDRALDLIVGPLYWRLVVVRGELPKGYLDDLAASAVAALRNG
>NC_021177.1|WP_015608904.1|2938779_2939730_+|ABC-transporter-permease
MVSQTAAPPSPAPSSVSAPDQAVPVYAPGELAALAARHGLTVSGARPPLPAYIRQLWGRRHFIAAFATAKLTAQYSQAKLGQVWQIMTPLLNATVYYFIFGVLLNTKHGVEDFVPFLVTGVFIWTFTSSSITAGTRAISGNIGLVRALHFPRASLPVALALQQLQQLLFSLGALTLILLVFGQYPRPSWLLAIPALALQAVFNTGVSMAVARLTAKTPDIAQLTPFVLRTWMYSSGVMWSLDHLLKGERVPHAVMVALEYNPAALYINLMRYALIDSYSAAQLPPHVWAAAAGWALLCGVAGFVYFWKAEETYGRG
>NC_021177.1|WP_015608905.1|2939722_2940514_+|ABC-transporter-ATP-binding-protein
MADLKDTSADHRVPTVVVDDVHITYTVNGARTGKGSATSALSRLTTRRRTPGARQVHAVKGVSFAAYKGEAIGLIGSNGSGKSTLLKAVAGLLPPTRGRVHTQGQPSLLGVNAALMGDLTGERNVVLGGLAMGMTRQQIRERYDGIVDFSGINEKGDFITLPMRTYSSGMGARLRFSIAAAKSHDVLLIDEALSTGDAKFQRRSRDRIKELRAEAGTVFLVSHSNKSITETCDRALWLEAGTLRMDGPAKEVVAAYEAFTKRK
>NC_021177.1|WP_015608906.1|2940640_2945623_-|NAD-glutamate-dehydrogenase
MQTKLDEAKAELLARAAQVADNSPGGGVGGPGGTPRVRVAATGADEDARPGQDVVLAYLQRYYLHTAPEDLSGRDPVDVYGAAASHYRLAENRPQGTANVRVHTPTVEENGWTCSHSVVEVVTDDMPFLVDSVTNELSRQGRGIHVVIHPQVTVRRDVTGKLIEVLTGGPGTPKRGGKAELPHDALVESWIHVEIDRETDRADLQQITADLLRVLSDVRETVEDWGKMRDAALRIAEDLPGEPLDDLADEEVEEARELLRWLAADHFTFLGYREYELKDSDALAAVPGTGLGILRSDPQHNVDEDHPVSPSFDRLPADARAKAREHKLLVLTKANSRATVHRPSYLDYVGVKKFDAKGNVVGERRFLGLFSSAAYTESVRRVPVIRRKVAEVVEGAGFSYNSHDGRDLLQILETYPRDELFQTPVDQLRAIVTSVLYLQERRRLRLYLRQDEYGRYYSAIVYLPRDRYTTGVRLRLIDILKEELGGTSVDFTAWNTESILSRLHFVIRVPPGTELAHLTDADADRIEARLVAAARSWADGFGEALNAELGEERAAELQRQYGHSFPEGYKADHSPRAAVADLVHLETLKEGEKDFALSLYEPVGAGPGERRFKIYRTGEQVSLSAVLPALQQLGVEVVDERPYELRCADRTHAWIYDFGLRMPQTNGHTGHLADDARARFQEAFAAVWRGEAENDGFNALILGAGLNWRQAVVLRAYAKYLRQAGSTFSQDYMESTLRNNVHTTRLLVSLFEARMSPGRQSAGTELTDGLLEELDGALDQVASLDEDRILRSFLTVIKATLRTNFFQNADDGTPHSYVSMKFDPQAIPDLPAPRPAFEIWVYSPRVEGVHLRFGKVARGGLRWSDRREDFRTEVLGLVKAQMVKNTVIVPVGAKGGFVAKQLPDPSVDRDAWFAEGIAAYRTFISALLDITDNMVAGEVVPPADVVRHDEDDTYLVVAADKGTASFSDIANEVAVAYGFWLGDAFASGGSAGYDHKGMGITARGAWESVKRHFRELGHDTQTEDFTVVGVGDMSGDVFGNGMLLSEHIRLVAAFDHRHIFIDPTPDAATSYAERRRLFDLPRSSWADYDTGLLSAGGGIHARSAKSIPLNNHIREALGIDASVSKMTPADLMQTILKAPVDLVWNGGIGTYIKAVSESNADVGDKANDAIRVNGEDLRAKVVGEGGNLGATQLGRIEFARKGGRINTDAIDNSAGVDTSDHEVNIKILLNGLVRDGDMTVKQRNKLLADMTEEVGALVLRNNYAQNVALSNASAQAPSLLHAQQRFMRRLEKDGALDRALEFLPTDRQIRELLNNDTGLSQPELAVLIAYTKITTADELISTVLPDDPHLQKLVHAYFPSQLRERFPEAIDGHALRREIITTVLVNDTVNTAGSTFLHRLREETGASIEEIVRAQFTAREIFGLSSVWDAVEALDNQVAADVQTRIRLHSRRLVERGSRWLLGNRPQPVAIAETIEGFRDGVEQVWNELPKLLRGADLDWYHSILDELTSVGVPDELAVRVAGFSSAFPALDIVAIADRTGKDPLEVAEVYYDLADRLRITQLMDRIIELPRADRWQSMARASIREDLYAAHAALTSDVLSVGNGSSTPEERFRAWEEKNAAILARSRSTLEEIQGSDAFDLANLSVAMRTMRTLLRTHA
>NC_021177.1|WP_015608907.1|2946072_2946660_+|DJ-1/PfpI-family-protein
MPEKILIVTGDAAESLEVLYPYQRLLEEGYEVDIAAPERKTLRFVVHDFEPGYDTYTEKPGYTFPADLAFSEVDPGAYIALVIPGGRAPEYLRNNAELRKIIGAFFSADRPVAQICHGPLITAATGSLSGRRVTAYPALEPDMQSAGATFQDTEAVVDGTLISSRAWPDHPAWMREFLKVLRTQSGPTKSSPSGV
>NC_021177.1|WP_015608908.1|2946708_2947386_-|HAD-family-hydrolase
MTPGKTRTHLVWDWNGTLLDDIHAVIHATNAAFAEVELAPLTLEQYREMYCVPIPRFYERLLGRLPTEAEWERMDDIFHRYYAEHRVACGLTAGAEDLLAQWKLAGHSQSLLSMYGHEHLVPVVRGYGIESHFVRVDGRTGPSGGSKALHMERHFEALAGVGGISPENSVVIGDAVDDAVAAAHVGARAVLYTGGSHSRSSLLAAGVPVVDSLGEAVALAETFSA
>NC_021177.1|WP_015608909.1|2947454_2947961_-|hypothetical-protein
MRVYVPLTLSGLAAAHADGEVGPGPLTAYAVTPGLREWYVSDDIEELEYAALNRAAAASLRLIAGNPDEARRRIVVAVDVPDGTATADPDHGLSAASLGEVRLATALPLAKAAAVHVDADEAEKDVAAAAAALGAADLGDDDAQFTVDGAEDHELLWFGVQEIPQLIG
>NC_021177.1|WP_032759021.1|2948237_2948684_+|hypothetical-protein
MSMDSTRPAGRRDQRRPQAVPPQRSRRLRPHRPPRPHQWFAERLLAVLSGQRPVHWMLGHTIGDAYDQLAELAPSTPLGAARGPRPVLRHCHGAQPASGVVEAFASITAGDRVQAMAFRLEQGPDQRWRCAAVELGGERLTAGHPGPR
>NC_021177.1|WP_015608911.1|2948752_2951569_-|preprotein-translocase-subunit-SecA
MSVFNKLMRAGEGKILRKLHRIADQVSSIEEDFVNLSDAELRALTDEYKERYADGESLDDLLPEAFATVREAAKRVLGQRHYDVQMMGGAALHLGYVAEMKTGEGKTLVGTLPSYLNALSGKGVHLITVNDYLAERDSEMMGRVHKFLGLSVGCIIANMTPAQRREQYACDITYGTNNEFGFDYLRDNMAWSQDELVQRGHNFAVVDEVDSILVDEARTPLIISGPADQATKWYGDFAKLVTRLTKGEAGNQLKGIEETGDYEVDEKKRTVAIHETGVAKVEDWLGIDNLYESVNTPLVGYLNNAIKAKELFKKDKDYVVIDGEVMIVDEHTGRILAGRRYNEGMHQAIEAKEGVDIKDENQTLATITLQNFFRLYTKLSGMTGTAMTEAAEFQQIYKLGVVPIPTNRPMVRADQSDLIYRTEVAKFAAVVDDIAEKHEKGQPILVGTTSVEKSEYLSQQLSKRGVQHEVLNAKQHDREATIVAQAGRKGAVTVATNMAGRGTDIKLGGNPDDLAEAELRQRGLDPVENVEEWAAALPAALESAELAVKAEFEEVKDLGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDDLMRLFKAQMVERVMSMANVPDDVPIENKMVTRAIASAQSQVEQQNFETRKNVLKYDEVLNRQREVIYGERRRVLEGEDLQDQIRHFMDDTIDDYIRQETSEGFAEEWDLDRLWGAFKQLYPVKVTVEELEEAAGDLAGVTAEFIAESVKNDIHEQYEEREKTLGSDIMRELERRVVLSVLDRKWREHLYEMDYLQEGIGLRAMAQKDPLVEYQREGFDMFNAMMEGIKEESVGYLFNLEVQVEQQVEEVPVQDAAERTSLAKEGAPAARPEIRAKGLEAPQRPDRLHFSAPTVDGEGGVVEGDFATDGAQSGSSDGMTRAERRKAQKSGGGGGRRRKK

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Crispr_ID: NC_021177_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_6

2982667-2982763

Orphan

Consensus_repeat	Method
GTGGGGTGGCTGAGCCCCCAGGGGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_6

>merge|NC_021177|6|2982667-2982763|CRISPRCasFinder
GTGGGGTGGCTGAGCCCCCAGGGGCTGAAAGGGCGGGGCCCCGGGAGTGAGGGGAACGGGGTGGGGCGGAGTGGGGCGGCTGAGCCCCCAGGGGCTG

>NC_021177|6|6|2982667-2982763|CRISPRCasFinder
GTGGGGTGGCTGAGCCCCCAGGGGCTG	AAAGGGCGGGGCCCCGGGAGTGAGGGGAACGGGGTGGGGCGGA
GTGGGGCGGCTGAGCCCCCAGGGGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015608936.1\|2985540_2987109_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015608928.1\|2976650_2978108_-\|adenosylhomocysteinase	unknown	unknown	gnl\|CDD\|377487
NC_021177.1\|WP_015608932.1\|2982145_2982328_-\|Trm112-family-protein	unknown	unknown	gnl\|CDD\|225391
NC_021177.1\|WP_015608925.1\|2973794_2974802_-\|stage-II-sporulation-protein-M	unknown	unknown	gnl\|CDD\|376676
NC_021177.1\|WP_032757326.1\|2993015_2993972_+\|2-phospho-L-lactate-transferase	unknown	unknown	gnl\|CDD\|237443
NC_021177.1\|WP_015608935.1\|2985094_2985454_+\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240574
NC_021177.1\|WP_014046372.1\|2991544_2991808_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NC_021177.1\|WP_015608927.1\|2975845_2976475_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015608930.1\|2979483_2980659_-\|mannose-6-phosphate-isomerase,-class-I	unknown	unknown	gnl\|CDD\|185085
NC_021177.1\|WP_015608940.1\|2993968_2995318_+\|coenzyme-F420-0:L-glutamate-ligase	unknown	unknown	gnl\|CDD\|183957
NC_021177.1\|WP_015608937.1\|2987105_2991131_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|224137
NC_021177.1\|WP_015608938.1\|2992501_2993002_+\|cysteine-dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|380416
NC_021177.1\|WP_015608933.1\|2982839_2984207_-\|phosphomannomutase/phosphoglucomutase	unknown	unknown	gnl\|CDD\|236557
NC_021177.1\|WP_043974431.1\|2966467_2967781_+\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NC_021177.1\|WP_073746234.1\|2984262_2984643_-\|DUF3499-domain-containing-protein	unknown	unknown	gnl\|CDD\|378788
NC_021177.1\|WP_106960216.1\|2965482_2966457_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_021177.1\|WP_015608941.1\|2995470_2996565_-\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NC_021177.1\|WP_015608931.1\|2980832_2981969_-\|sugar-isomerase	unknown	unknown	gnl\|CDD\|378434
NC_021177.1\|WP_015608926.1\|2974922_2975849_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|224628
NC_021177.1\|WP_015608929.1\|2978379_2979396_-\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015608928.1\|2976650_2978108_-\|adenosylhomocysteinase	gnl\|CDD\|377487	pfam05221, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.	0
NC_021177.1\|WP_015608932.1\|2982145_2982328_-\|Trm112-family-protein	gnl\|CDD\|225391	COG2835, COG2835, Uncharacterized conserved protein [Function unknown].	8.08483e-14
NC_021177.1\|WP_015608925.1\|2973794_2974802_-\|stage-II-sporulation-protein-M	gnl\|CDD\|376676	pfam01944, SpoIIM, Stage II sporulation protein M. SpoIIM is on e of four stage II sporulation proteins that is necessary for the forespore inside the mother-cell to be properly internalized through the breakdown of peptidoglycans trapped between the membranes of the septum separating the forespore and the mother-cell. The four proteins working in sequence are SpoIIB, pfam05036, SpoIIM, SpoIIP, pfam07454, and finally SpoIID, pfam08486. D, M and P are in a complex with each other and the complex assembles in a hierarchical manner such that M, which serves as a membrane anchor, recruits P to the septum and P, in turn, recruits D to the septum.	1.51851e-39
NC_021177.1\|WP_032757326.1\|2993015_2993972_+\|2-phospho-L-lactate-transferase	gnl\|CDD\|237443	PRK13606, PRK13606, LPPG:FO 2-phospho-L-lactate transferase; Provisional.	3.69425e-173
NC_021177.1\|WP_015608935.1\|2985094_2985454_+\|metallopeptidase-family-protein	gnl\|CDD\|240574	cd12954, MMP_TTHA0227_like_1, Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria. The subfamily includes some uncharacterized bacterial proteins which show high sequence similarity with Thermus thermophilus hypothetical protein TTHA0227. However, they do not contain the conserved HExxH (x could be any amino acid) motif. They may not have any zinc metallo-peptidase activity.	1.9795e-26
NC_021177.1\|WP_014046372.1\|2991544_2991808_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.84841e-28
NC_021177.1\|WP_015608930.1\|2979483_2980659_-\|mannose-6-phosphate-isomerase,-class-I	gnl\|CDD\|185085	PRK15131, PRK15131, mannose-6-phosphate isomerase; Provisional.	3.21127e-109
NC_021177.1\|WP_015608940.1\|2993968_2995318_+\|coenzyme-F420-0:L-glutamate-ligase	gnl\|CDD\|183957	PRK13294, PRK13294, F420-0--gamma-glutamyl ligase; Provisional.	0
NC_021177.1\|WP_015608937.1\|2987105_2991131_-\|glycosyltransferase	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	1.77446e-32
NC_021177.1\|WP_015608938.1\|2992501_2993002_+\|cysteine-dioxygenase-family-protein	gnl\|CDD\|380416	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain. This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.15548e-22
NC_021177.1\|WP_015608933.1\|2982839_2984207_-\|phosphomannomutase/phosphoglucomutase	gnl\|CDD\|236557	PRK09542, manB, phosphomannomutase/phosphoglucomutase; Reviewed.	0
NC_021177.1\|WP_043974431.1\|2966467_2967781_+\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.90556e-43
NC_021177.1\|WP_073746234.1\|2984262_2984643_-\|DUF3499-domain-containing-protein	gnl\|CDD\|378788	pfam12005, DUF3499, Protein of unknown function (DUF3499). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.	1.05493e-59
NC_021177.1\|WP_015608931.1\|2980832_2981969_-\|sugar-isomerase	gnl\|CDD\|378434	pfam10432, bact-PGI_C, Bacterial phospho-glucose isomerase C-terminal SIS domain. This is the C-terminal SIS domain of a bacterial phospho-glucose isomerase EC:5.3.1.9 protein which is similar to eukaryote homologs to the extent that the sequence includes the cluster of threonines and serines that forms the sugar phosphate-binding site in conventional PGI. This domain contributes a good proportion of the active catalytic site residues. This PGI uses the same catalytic mechanisms for both glucose ring-opening and isomerisation for the interconversion of glucose 6-phosphate to fructose 6-phosphate. It is associated with family SIS, pfam01380.	2.13939e-16
NC_021177.1\|WP_015608941.1\|2995470_2996565_-\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	2.52388e-27
NC_021177.1\|WP_106960216.1\|2965482_2966457_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.71091e-101
NC_021177.1\|WP_015608926.1\|2974922_2975849_+\|RDD-family-protein	gnl\|CDD\|224628	COG1714, COG1714, Predicted membrane protein/domain [Function unknown].	3.27897e-15
NC_021177.1\|WP_015608929.1\|2978379_2979396_-\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	1.25084e-40

>NC_021177.1|WP_015608932.1|2982145_2982328_-|Trm112-family-protein
MPLEAGLLEILACPACHSPLDDRTAADSPELVCTGADCGLAYPVRDGIPVLLVDEARRPA
>NC_021177.1|WP_015608931.1|2980832_2981969_-|sugar-isomerase
MLDESLLDAPEALARADRRDLLRGAAEAGARVRTATRHAAEAGIGGLNPEGRPRAVLVAGPGTAASGVADLIGALAGAAAPVTRIHPTGVAPAPGALRWTLPGWAGSVDLLLIATADGSEPGLALLAEQAYRRGCTVVAVAPTRSPLREAVDGVHGLVVPMAAAPHGEYDAETSAAGPGTLWALLTPLLALLDRVGLVTAPAEELQKVADRLDRTAERCGPAIATYSNPAKTLAAELADSLPLLWTEGAAAGPVGRRFAAVLSELAGRPALAAELPEALPSHGTLLAGDFAAGADPDDFFRDRVDEGETLRARVVLLRDRPTGGLSAYPAARELALGHDTPVSELEPEEGSALETLAELLAITDFAAVYLSLASAPQP
>NC_021177.1|WP_015608930.1|2979483_2980659_-|mannose-6-phosphate-isomerase,-class-I
MDRLSNTVRPYAWGSTTAIPALLGIAPTGEPQAEMWMGAHPGAPSRISRTAPAGETELALTEAIDADPEGELGAATVARFGPRLPFLLKLLAAGAPLSLQVHPDLDQARKGYEDEEARGVPIDAPHRTYKDANHKPELICALTPFDGLCGFRRPTEAADAMEALGVDSLKPYVDLLRAHPEEAALREVLTAILSADPAEMADTVAEAAVAAERLGGAHAPYARIAHNYPGDPGVLAAMLLNYVRLQPGEALFLGAGVPHAYLDGLGVEIMANSDNVLRCGLTPKHIDVPELLRIVRFEATEPGVLRPEASPSGEERYETPVDEFVLSRYTLASGAAPAELTAPTPQILLCTAGAVRVGELGLTPGQSVYVPAGEAVEAAGSGTLFRATVAA
>NC_021177.1|WP_015608929.1|2978379_2979396_-|cation-diffusion-facilitator-family-transporter
MSASGGTKAIVAALVANLSIAVAKFVAFLFSGSSSMLAESVHSLADSGNQGLLLLGGKKAKREATPEHPFGYGRERYIYAFLVSIVLFSVGGMFAVYEGYEKIKHPHEITAWYWPVGVLVFAIIAEIFSFRTAIKESNQTRGNRSWTEFVRRSKAPELPVVLLEDLGALVGLVLALGGVGLALATGNGVWDGIGTLCIGILLIVIAIILAVETKSLLLGESAGLEEVEKIKAAVVDGDTVTGIIHMRTLHLGPEELLVAAKIAVRHDETATEIANAINAAENRIREAVPIARVIYLEPDIFNAEAAAAGTTPGDPSDAPAPAPAPDPAPAPAPKDLGH
>NC_021177.1|WP_015608928.1|2976650_2978108_-|adenosylhomocysteinase
MTTVANRQDFKVADLSLAAFGRKEITLAEHEMPGLMSIRKEFAAAQPLAGARVTGSLHMTVQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAIAVGPNGTPEAPAGVPVFAWKGETLEEYWWCTEQALTWPNTPTGGPNMILDDGGDATLLVHKGVEFEKAGAAPDPSTADSEEYAYILTLLNRTLGESPQKWTQLASEIRGVTEETTTGVHRLYEMHRDGTLLFPAINVNDAVTKSKFDNKYGCRHSLIDGINRATDVLIGGKTAVVCGYGDVGKGCAESLRGQGARVIITEIDPICALQAAMDGYQVATLDDVVEQADIFITTTGNKDIIMASDMARMKHQAIVGNIGHFDNEIDMAGLAAIDGIVKDEVKPQVHTWKFPDGKVLIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELFTKPEEYPTDVYVLPKHLDEKVARLHLDALGVRLTTLRPEQASYIGVEVEGPYKPDHYRY
>NC_021177.1|WP_015608927.1|2975845_2976475_-|hypothetical-protein
MPRGRYSLHDLHDHTPLGEEHFHCAPGPSGWRYVSQTTSPSGDHLGSVDLALDELGRPIRLELHSESWQVRGAALEGVTWVRTDPTGTHATEGNVRAHAFSGTSPAFLVALTRLLRLTPDSPETRVRVVTFTDPVLAPRTNDQSWALVNSEAHATDNGPLIVDTYQVSALDTGDQHTVHIAGDVVLAAPGIELEHLETPPSPRTSEHSG
>NC_021177.1|WP_015608926.1|2974922_2975849_+|RDD-family-protein
MSELVTGDAVVLGLRPARLPSRALAAAIDLAVVFCVFMLVSVVVAVASVTLDEAAVAAITVALFLLVLIGGPIAVETLSHGRSLGKLACGLRVVRDDGGPIRFRHALVRGAMGAVEILMTFGVVASIASLVSARGRRLGDVFAGTLVIRERVAAKRSVAVPPPPPWLVGRFSQLDLSAVPDELWLAIRQYLTRMHQLDPGVGGSIAGRLADELVTRTGIAPPQGVPAAAFLAAVVHERQARDARRVFAGARNASSAPPAPTVFPGSAGFAAPAGPVADGSGAAGGTRPGHGPGPEGAGASSAGFAPPG
>NC_021177.1|WP_015608925.1|2973794_2974802_-|stage-II-sporulation-protein-M
MDLDVFVTAHRTEWDRLDHLLRRGRSLTGAEADELVVLYQRTATHLSLIQSTTPDPLLTARLTQLVARARATVTGTRKASWRDAARFLTAGFPAAVYRSRHWWVPTAVLSTVVAALLGWWIGTHPEVQAAIAAPEDLRAMTRPGGEYETYYSSHPAASFAAQVWTNNAQAAAMCLVLGAFLCLPVIWILFLNMLNLGVGIGLMSSAGRLDVFLGLVLPHGLLELTAVFVAAGTGLRLGWTVIDPGPLSRRTALAQQGRAALGMAIGLALVLFVSGVIEGFVTPSGLPTWARITIGIAAELAFLAYVYILGRRAVRAGDIGDLTAVERSAELPSAA
>NC_021177.1|WP_043974431.1|2966467_2967781_+|DUF58-domain-containing-protein
MALTGRTALLAALGSLPVGILAPSWTGMLAVNAPLSLAILCDYALAAPVRTLRFTRSGDTSVRLGDAAEVQLTVTNSSRRRLRAQLRDAWPPSSWPAGTEQVSSRHTLTVPPGEQRRLATVLRPTRRGDRQAERITVRSFGPLGLAARQGHHRVPWTVRVLPPFTSRKHLPSRLARLRELDGRTSVLTRGEGTEFDSLRAYVPGDDTRSIDWRATARQSAVAVRTWRPERDRHILIVLDTGRTSAGRVGDVPRLDAAMDATLLLTALATRAGDRVDLLAYDRRVRARVQGRTAAGDVLATVVNTLASLEPKLVETDARGLSTAALSDAPRGSLIVLLTTLEAAPIEEGLLPLLPQLTRRHTVLLAAVSDPRITEMAKGRGTVDAVYDAAAGTQAQSERRSTAEKLQRHGVVVVDATPDSLAPALADAYLALKAAGRL
>NC_021177.1|WP_106960216.1|2965482_2966457_+|MoxR-family-ATPase
MTPAAPEPADGARASLEALRSEIAKAVVGQDAAVTGLVVALLCRGHVLLEGVPGVAKTLLVRALAASLELDTKRVQFTPDLMPSDVTGSLVYDARTAEFSFQPGPVFTNLLLADEINRTPPKTQASLLEAMEERQVTVDGTPRLLPDPFLVAATQNPVEYEGTYPLPEAQLDRFLLKLTVPLPSRHDEINVLTRHADGFDPRDLKAAGIRPVAGPADLEAARSAVAKTSVSPEIAGYVVDICRATRESPSLALGVSPRGATALLSTARAWAWLTGRDYVTPDDVKALALPTLRHRIHLRPEAEMEGVTPDSVITSVLAHVPVPR
>NC_021177.1|WP_015608933.1|2982839_2984207_-|phosphomannomutase/phosphoglucomutase
MVADLSQLVKAYDVRGVVPDQWDESLAELFGAAFVQVTAADAIVIGHDMRPTSPGLSGAFARGAAARGADVTLIGLCSTDQLYYASGALDLPGAMFTASHNPAQYNGIKMCRAGAAPVGQDTGLKEIRTLVEQWSEGAPQPPASATPGTITERDTLTDYASHLLALVDLTSIRPLKVVVDAGNGMGGHTVPTVFEGLPLDVVPLYFDLDGTFPNHEANPLDPKNIVDLQARVLAEGADLGLAFDGDADRCFVVDERGAGVSPSAITALVAARELARNGGKGIVIHNLITSWSVPEVVRENGGTPVRTRVGHSFIKTEMAEHGAIFGGEHSAHYYFRDFWNADTGMLAALHVLAALGGQPGPLSELVAAYDRYAGSGEINSTVADQTASLATIRAAYGNRDDITFDDLDGLTVTSTDWWFNLRASNTEPLLRLNVEARDGATMEAVRDEVLGLIRS
>NC_021177.1|WP_073746234.1|2984262_2984643_-|DUF3499-domain-containing-protein
MVSPVRRCSRTACGRPAVATLTYVYADSTAVLGPLATYAEPHCYDLCAEHSERLTAPRGWEVVRLSDGSAPAHPSGDDLEALANAVREAARPHDRGPDGGGRGPRSADPVEVARRGHLRVLRSPDS
>NC_021177.1|WP_015608935.1|2985094_2985454_+|metallopeptidase-family-protein
MRGPVAPPQVPLSASRGEVFRDLVQDSVERLERRWPQLAEVDFVVLDVPGDLEESVPLGTAVPAAKGRPAQIVVYRRPVEIRSKNRDERALLVHEVVVEQVAELLGLAPESVDPRYGQD
>NC_021177.1|WP_015608936.1|2985540_2987109_-|hypothetical-protein
MKSTHLSLIAGTVALAAITGFATLNAPGGPAAAEAGSASSLPVERSSLVCPAPSTSDLAETQYTSYTPPGSETAKGGGAKGEGAEGTAELKPALPVLDDDEVETDPKKIKKAEEAAKKAKAQADKPVLAVKEPGTPVLAEADGSAAPALVGTATGRLAPGWAAQQTTTVTAGGARGLLGVSCTAPDTDFWFPGVSTARSRQDYVHLTNPDDSAAVADIELFGAKGAVTSEVGDGITVPARSSVALLLSTLTDEAVNDLTAHVTTRSGRVGGVVLTADDGSGADWLTAAADPSGTLVMPGIPADATSVQLVAFAPGENDADVKVQLMGKNTTFAPAGNDTLHIKSGMTATIDLKDITRGEPGSLRLTPVEKNRATPIVAALRVVRGTGAKQEIAYIPATGPVGARASVTDNRAKGSTLSLAAPAATAKVKVTTSAGSGGGEPAVETYTVKAGTTTAITPKPPAGLKGAYALTVETVSGGPVHASRALVLPEGGVQMFTIQTLPDDGGTVVVPSARQDLSVLDD
>NC_021177.1|WP_015608937.1|2987105_2991131_-|glycosyltransferase
MSVHSHSAAPNAAAAAPEFPRHVVTAVLVSHDGARWLPDVLAGLLGQERPVQNVVAADTGSADDSARLVTEALGGDRVLHLARRTSFGTAVDEAVRTAGPLTPDDLPYLKRPGGWDPVTRAWVDENYDLPELPHGEPVQWLWLLHDDCAPEPDALAEMLRVVDTDKHATIVGPKLRGWYDRKQLLEVGVSIANSGRRWTGLDRREQDQGQHDQVRTVLSVSSAGMLIRRDVYDELGGFDRSLPLMRDDVDLCWRAHLAGHRVLVAPDAVLRHAEASARERRPIDCAGRSVVGPHRVDKAGAVYTMLVNARAKALPWVLLRLVVGTLLRTLAYLVGKVPGQALDEVTGLLGTLLRPGRILAARRARGKGVVDAAELRALFPPPGATVRATVDQVAGNFGGRGEAESGGSRHGAVESGPGGDDADFLEVDQFARLKRIGRKPGPVLFVLLLVVSLIACRNLLTGGSLAGGALLPAPAEAGELWGRYADAWHTISTGSTETAPPYLALLAALAALFLGSTGFAVAAILVCSVPLAGLTAYFASRPLLPSRLLRAWASIAYAFLPAATGALATGRLGTAVLLVLLPLIARAAVAAHGLRNGPGADAARGSWRATWAYALLLTVTTAFTPIVWPLAVVLGLGVLALRRHDITAYGLRFLAAVGTPMLALAPWSLTLLTDPSAFLREAGLDIGTGTASALDLLGISPGGPNAAGGLLLLGIVLAALAALLRGERQFAVRTAWATALVGLLFAALANGSTWAGPATLVYGAALIAAALVGADGARVRVAEQSFGWRQPVAALIALAAGLAPVLAAFGWMVGGADGPLERRDPVQVPAFVAEESSTRDQARTLVLGGTSPESVSYSLVRGSGARLGDGELTEAAGSNSQLDKVVANLVAGSGADQGGQLGNFAIRYVLVRDGAPRQMSRVLDTTPGISRLSQLDGSALWRVDRQVARVMVVPAGGEGERVPVGSGPVEAHSKIPAGDEGRILRIADEAAPGWQATIDGKPLTRVTVDGWAQGFELPAGGGRLDLTFDAPFTHTVWLWAQGALALVLVVMALPGRRREIDDDLPEEALAVAADAADGDGRRARRLRAAAEAEAMAAEAAGTTEDGYPADAPGDFPPPPPAAPPAAPPSAPATAQAEEAGPVPVPVPGSGSGEYIPDQQSTDPHAENGGYAPQPGYDPQDTTGGYAALPQQQGYGEWDGRQYQAADQQAAAPYQQGDYAAYQQDPYTQQNTGYSSAYPDQGGYGPQDPYGQQQQQQQQYGGEGDGQYSPGQYDQQGQYEQQGRQSQYDQYGRYTGEQPPYAAPDRHPAENAGNGENGEQPDIPAPGETPWQTRNASRGESE
>NC_021177.1|WP_014046372.1|2991544_2991808_-|WhiB-family-transcriptional-regulator
MTELFQQLLVEDADEELGWQERALCAQTDPESFFPEKGGSTREAKKVCLACEVRSECLEYALANDERFGIWGGLSERERRRLKKAAI
>NC_021177.1|WP_015608938.1|2992501_2993002_+|cysteine-dioxygenase-family-protein
MNSDSDLQIAGDILEVQHLLQPAREHPSTVSEFVGLARSIAADRARWAGLVRYDTTTRWYHRLQTGPGYEVWLLSWVPGQGSGRHDHGRSAGVLTVLEGELTEHTERGSQSLGAGTQRAFAPGYVHEVVNDSLEPAVSLHIYYPGLTEMPMHAAQCAPTAVDVVPA
>NC_021177.1|WP_032757326.1|2993015_2993972_+|2-phospho-L-lactate-transferase
MRIVVLAGGIGGARFLRGLKQAAPEADITVIGNTGDDIHLFGLKVCPDLDTVMYTLGGGINEEQGWGRTDETFQVKDELAAYGVGPGWFGLGDRDFATHIVRTQMLGAGYPLSAVTEALCARWQPGVRLLPMSDDRVETHVAVEMDGESKAIHFQEYWVKLRASVEAQAIVPVGAEQAKPAPGVLEAIGAADVIVFPPSNPVVSIGTILAVPGIREAIAEAGVPVVGLSPIVGDAPVRGMADKVLAAVGVESTAAAVAQHYGSGLLDGWLVDTVDAGTVGEVEAAGIRCLAVPLMMTDVDATAEMARQALDLAEEVRA
>NC_021177.1|WP_015608940.1|2993968_2995318_+|coenzyme-F420-0:L-glutamate-ligase
MSGVGSADVDGGGSAPSFRVWALGGIPEVRAGDDLAKLIAGAEPGLVDGDVLLVTSKIVSKAEGRIVEAADREAAIDAETVRVVARRGTLRIVENRQGLVMAAAGVDASNTPAGTVLLLPEDPDASARAIRDGLRDTLGVEIGVVVTDTFGRPWRNGLTDVAIGAAGVRVLDDLRGGTDAYGNPLSATVVATADELAAAGDLVKGKAAGLPVAVVRGLPHVVSPGAGDEDDPGARALVRGAADDMFRLGTSEAVREAVTLRRTVREFSDEPVDPGAVRRAVAAAVTAPAPHHTTPWRFVLLESAESRTRLLDAMRDAWIEDLRRDGKSEESIAKRVRRGDVLRNAPYLAVPCLVMDGSHTYGDVRRDTAEREMFVVAAGAGVQNFLVALAGERLGSAWVSSTMFCRSVVREVLALPESWDPLGAVAVGHAVGVARERAVRDAEDFLTVR
>NC_021177.1|WP_015608941.1|2995470_2996565_-|DNA-3-methyladenine-glycosylase-2-family-protein
MAGRFAPRTARPTLPHQAAQAVRREKGLARGEEGPARGEEGLARGGEGPVRGDGAPVRGDERPLTREWTPPGPLDLRLVLGPLRRGPADPTFRMPPDGTFWRATRTPEGPGTLRVAARGGRVGAQAWGPGAEWLLAGLPALLGADDDPDAFTPHHRLLAVARHRRPGLRLLRTGLVMESLIPSILEQKVTTDEAYRAWRLLVRRYGTPAPGPTAALGLHVMPDARTWAMIPSWEWHKAGVDTKRSSTIMRAVRVAPRLEEASAMELPRATARLELIPGIGPWTSAETLQRSNGAPDAVTVGDYHLPGIVGHALADNRHADDEEMLTLLTPYEGQRHRATRLILLSGRIPERRGPRMTPGNIAAL

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Crispr_ID: NC_021177_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_7

3123012-3123086

Orphan

Consensus_repeat	Method
GGCTGGAATTCGGGGCCCGTCTCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_7

>merge|NC_021177|7|3123012-3123086|CRISPRCasFinder
GGCTGGAATTCGGGGCCCGTCTCAGACACCGGACGGGCCGGGGTAGGCGCGGCTGGAATTCGGGGCCCGCCTCAG

>NC_021177|7|7|3123012-3123086|CRISPRCasFinder
GGCTGGAATTCGGGGCCCGTCTCAG	ACACCGGACGGGCCGGGGTAGGCGC
GGCTGGAATTCGGGGCCCGCCTCAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015609049.1\|3122272_3122767_+\|SUKH-3-domain-containing-protein	unknown	unknown	gnl\|CDD\|379608
NC_021177.1\|WP_015609058.1\|3133510_3134512_+\|fatty-acid-desaturase-(membrane)	unknown	unknown	gnl\|CDD\|224316
NC_021177.1\|WP_031124212.1\|3120478_3121456_-\|cell-wall-assembly-protein-Knr4	unknown	unknown	gnl\|CDD\|379604
NC_021177.1\|WP_015609056.1\|3129880_3130351_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015609054.1\|3128442_3129027_+\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534
NC_021177.1\|WP_015609052.1\|3125688_3127137_+\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184641
NC_021177.1\|WP_015609057.1\|3130389_3133119_-\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|366019
NC_021177.1\|WP_015609046.1\|3117830_3120482_-\|SUKH-4-multi-domain-protein	unknown	unknown	gnl\|CDD\|373070
NC_021177.1\|WP_043972338.1\|3114222_3115137_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NC_021177.1\|WP_015609040.1\|3113082_3113457_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367559
NC_021177.1\|WP_078618676.1\|3116674_3117574_-\|cellulose-binding-protein	unknown	unknown	gnl\|CDD\|173412
NC_021177.1\|WP_015609053.1\|3127256_3128234_+\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|179535
NC_021177.1\|WP_015609039.1\|3112489_3113086_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227053
NC_021177.1\|WP_032757238.1\|3115419_3116184_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015609059.1\|3134508_3135189_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_021177.1\|WP_015609051.1\|3124628_3125501_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015609050.1\|3123119_3124472_-\|two-component-system-sensor-kinase	unknown	unknown	gnl\|CDD\|226951
NC_021177.1\|WP_015609048.1\|3121848_3122262_+\|YwqJ-deaminase-domain-containing-protein	unknown	unknown	gnl\|CDD\|373065
NC_021177.1\|WP_015609055.1\|3129170_3129764_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NC_021177.1\|WP_015609041.1\|3113503_3114055_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015609049.1\|3122272_3122767_+\|SUKH-3-domain-containing-protein	gnl\|CDD\|379608	pfam14433, SUKH-3, SUKH-3 immunity protein. This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems.	6.96013e-59
NC_021177.1\|WP_031124212.1\|3120478_3121456_-\|cell-wall-assembly-protein-Knr4	gnl\|CDD\|379604	pfam14414, WHH, A nuclease of the HNH/ENDO VII superfamily with conserved WHH. WHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif WHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. WHH is the shortest version of HNH nuclease families. Like AHH and LHH, the WHH nuclease contains 4 conserved histidines of which the first one is predicted to bind a metal-ion and other three ones are involved in activation of water molecule for hydrolysis.	3.40487e-13
NC_021177.1\|WP_015609054.1\|3128442_3129027_+\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	2.0161e-65
NC_021177.1\|WP_015609048.1\|3121848_3122262_+\|YwqJ-deaminase-domain-containing-protein	gnl\|CDD\|373065	pfam14431, YwqJ-deaminase, YwqJ-like deaminase. A member of the nucleic acid/nucleotide deaminase superfamily prototyped by Bacillus YwqJ. Members of this family are present in a wide phyletic range of bacteria and a few basidiomycetes. Bacterial versions are predicted to function as toxins in bacterial polymorphic toxin systems.	2.22346e-17
NC_021177.1\|WP_015609057.1\|3130389_3133119_-\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|366019	pfam00311, PEPcase, Phosphoenolpyruvate carboxylase.	0
NC_021177.1\|WP_015609046.1\|3117830_3120482_-\|SUKH-4-multi-domain-protein	gnl\|CDD\|373070	pfam14440, XOO_2897-deam, Xanthomonas XOO_2897-like deaminase. A member of the nucleic acid/nucleotide deaminase superfamily prototyped by Xanthomonas XOO_2897. Members of this family are present in a wide phyletic range of bacteria and are predicted to function as toxins in bacterial polymorphic toxin systems. The Xanthomonas XOO_2897 lack an immunity protein and is predicted to be deployed against its eukaryotic host.	1.57503e-34
NC_021177.1\|WP_043972338.1\|3114222_3115137_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.2129e-07
NC_021177.1\|WP_015609040.1\|3113082_3113457_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	2.54223e-26
NC_021177.1\|WP_078618676.1\|3116674_3117574_-\|cellulose-binding-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	4.2439e-09
NC_021177.1\|WP_015609053.1\|3127256_3128234_+\|ribose-phosphate-diphosphokinase	gnl\|CDD\|179535	PRK03092, PRK03092, ribose-phosphate diphosphokinase.	0
NC_021177.1\|WP_015609039.1\|3112489_3113086_-\|hypothetical-protein	gnl\|CDD\|227053	COG4709, COG4709, Predicted membrane protein [Function unknown].	2.29974e-05
NC_021177.1\|WP_015609058.1\|3133510_3134512_+\|fatty-acid-desaturase-(membrane)	gnl\|CDD\|224316	COG1398, OLE1, Fatty-acid desaturase [Lipid metabolism].	1.74663e-70
NC_021177.1\|WP_015609059.1\|3134508_3135189_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.70101e-19
NC_021177.1\|WP_015609055.1\|3129170_3129764_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	1.97609e-94
NC_021177.1\|WP_015609050.1\|3123119_3124472_-\|two-component-system-sensor-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.57843e-32
NC_021177.1\|WP_015609052.1\|3125688_3127137_+\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184641	PRK14352, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NC_021177.1\|WP_015609041.1\|3113503_3114055_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	3.33857e-21

>NC_021177.1|WP_015609049.1|3122272_3122767_+|SUKH-3-domain-containing-protein
MHDHQHTSTRFPVGVDAALREAGWQPGRWDIRQAEEWADALRAHTSPAGHRHAVFPAAVEAWAEFGALHITASAPGRHIAPAAVRIDPLHGLHLARTLGDLGRALETEVAPLGAEGDEQAVLAIDTEGRVYSIDHTGDWFLGQDIDEALATMVTGTQPTRLTGA
>NC_021177.1|WP_015609048.1|3121848_3122262_+|YwqJ-deaminase-domain-containing-protein
MAAALSVRGETLTCTAGKGDQPPALHPLVQDFLDTLTSGQRERFTGRCPEAILLSRQLTAAENGRSKRAQRKPLTNGEARRALKHSRITARRIREDGDPLHGSYAPPCRSCSALLAHFGVRPVDLTTTGAATTAEKG
>NC_021177.1|WP_031124212.1|3120478_3121456_-|cell-wall-assembly-protein-Knr4
MTTGRLGQQAAPPNAAYAGQVVHFPDPVRASRHPRGVRVGESGHPDFSPYARAAAEIADPPQGFGVDELRLTDYVSANAAMAAAGHELWDTIPAVATPHGWTWHHVSGGRRMELVPVEVKALLRHHGGLATTDVDQDRRGTRPLQETRPAHFRLPKGAVAVSEQQIQGVEEDLGYRLPGAYRSFLKAAGGSAPVDAALDAELGLLVDQPFFTVRDEAAVNDLVYVNKCLRDHFTKDYLGVAFVQGGILAVKVRGQDVGSVWFCPYDDARDQDGWSVQERVERLLLPCGADFDAFLQRLAGNPPELETVANLMVDGGFARAVPVEG
>NC_021177.1|WP_015609046.1|3117830_3120482_-|SUKH-4-multi-domain-protein
MSAVVTFAQAQERADEWVNGDVPAYQHREVRVREFELGFVVWAEDRAEGPVSDGGRQRLVIARDSGEATLWPGLPVGEVIRRYEEEYGVPAGAPAAAPEPPQRVDLNQTSFLLTPPEWLQEAADKLGIPDHRAERRAAEEAADAASAGSVPAGSVPAGSAAGSVPGGTPLAGTPVPAPADEPVPTPAPADATPAHATPADATPVDATPPPSASPAAPSSGGSSASWPAAGSSAGGAYEPTANDGVPAGSTPWAGTDTNSFDSDDAAVPLPATVFAPPLSGTDDEEAPPPVVSAEAPTALMSGGSQLPRTQVSPALRPVQGSQDSPPSQGGTGDIADAATSKAVVPPRGARGGGSTTPPPPGAPGIPGVRPGATPPPSGPGAPGAPAGGYIPTQLVSQLGPPGPPGATPPPAPPGPPPGSTPPPGGGVHHAATMLADGSSIGAGVPGAPRPPGPPGAPGAPLPPGPPGVPGAPQPPGPPGPPPGATPPPGGGMHHAETMFANSGPIPVPGPPNPPGPPGPPGPPGAPLSGAPGPVPQAPQAGGPHTPPPPAYGYPQQPTGLPTVGPGYQAVLRFRAPDGSEQQLIRRSAPGTPHPEWQMLHELRAMNVPPQQVIELHTELESCELPGGYCARMIRETWPQVRITSVAPYGTDHASRQQGMQHLLTHQGELHQVADGPARPAPVRAPLPQMPPAPVLPPEAVAEELLQAFGPQGILRFDQRAVSRQGVPEIVARTLVWAGLPADFGPFFWAQPGQPVVPTLGEVAAQRQVQAAPDAGSYLVMGTDFGRAICVQYGTANIVAVPVEAGPGGQSAAPQFVNTGLPEFVRSMALLGRMWRLRFGLTPEQAGRWTVDFQAQLVALDPAALASPESWWSVLLEQMWDGLL
>NC_021177.1|WP_078618676.1|3116674_3117574_-|cellulose-binding-protein
MSAGPVSAFDVVGVRGRGYRPDQVDRAVAARTAERATALAEAERLERLAQELAAEAARLAETVAGLPEQDYAELGERAQRILGLAREQAESLRADAEAAGQELRDEAEAAGRAAGDAAREAADAVRAAAVAAAEERVAEAVREAEGVLAAARKEAEEVRGAAEAAMAQTRSRTASVLAHQEQEHADRHKAAEAEIAAAEAELEARHAELTERAEALLAEAARGLAEAQEAARHGQEDAEARAAEVLSEARVREERIVRETERVLREHEEGREEAQAHMAHVRSSLAALTGRVTGGAEEG
>NC_021177.1|WP_032757238.1|3115419_3116184_+|hypothetical-protein
MVLTTLTAPPAQAAPTGLVVSNVVVNNGKPIVVGTKEEKEPPVTFQVSLPPGLSTSKPSAYTAKPFLYRGAKLPKIPDNDSLRMGMYTCYPVNDWNERCEGTLFIDPPYDLDSNGDATTWKVGLTLRLWKPDGRLKAEEYKKAPGSVQLKRWGKATVNASPEPVKKGKKLTVTGKLTRADWVKHTYTGVAGSAKLQFRKKGSSAYTTVKTVKSNSAGALKTTVTASVDGYWRWTHNGSSTTGPATSTADFVDVR
>NC_021177.1|WP_043972338.1|3114222_3115137_+|helix-turn-helix-domain-containing-protein
MAALFGTRVRKLREAAGLTQTEVGARTHVVGSRITQIERATGAKPTLELTRALDRELVADDLLIDLWPYVYREAYPDWSQAFIAYSARAAVIRQYSSHAVPGLLQTPEYARALLSMGHSLRDAEHLEERVAARLDRQVRLTGPDRPELWIILDEAVLRRPVGGSAVMRGQLEKLLRMAEEPNITVQVLPFDQGAHGALAGSLTVLVLPDGIQVAYTEGAHNGQLTEEPEEVERFVLTYDHLRAMALPPLMSLELIRSVLEVDYRGSRVPSRSDRRRLAQQQLQQRGGRRLRAGGGRIPRRRPGP
>NC_021177.1|WP_015609041.1|3113503_3114055_-|ATP-binding-protein
MVPMTGKRMSAAEKADGLEEAPSVRRGFGLSGNGYGSLSRQFPSTPQGAQEARHAVVRQLGQWGFGPMADVSCTVALVVAELAANAVRHGSLPGTEFAVRVDHEGAASRFRIEVSDARLGRTPEEPVLPPDDRESGRGLFLVECLATRWGWEPRHPIGKTVWAEVAAGRPQEASVRTREASVD
>NC_021177.1|WP_015609040.1|3113082_3113457_-|PadR-family-transcriptional-regulator
MEPGDSTKQARAAAQLRKGVLEYCVLALMRDRPRYGVELLQALEESGALATSQGTVYPLLSRLRRDDLVTTTWQESASGPPRRYYALTDSGRAALDEFTRVWPGFRDAVDTFLATPHPSTGDLA
>NC_021177.1|WP_015609039.1|3112489_3113086_-|hypothetical-protein
MKTSQDPVRDYLSAVEREASDLPADRRQELVADLAEHIEVARAERPDAVIGEILAELGDPRAIAATALAESGTGPAASPAWGGSGAPARRGKVHPLVPVLLLALAQPVGMVFPDEGGSLIGGLVRITGAVLLCTSVHWTARRKIIGVLLAVVLPGVAMGVWNLSDGAPEGSGPALVANLAASALMAGTAAWLWRVRRA
>NC_021177.1|WP_015609050.1|3123119_3124472_-|two-component-system-sensor-kinase
MTATGADREAAGSTTRGYWWWERRRSVALDVGLALVSALECGLEGVDFAGDAGLPAPVGVVFGLLAGSVLLVRRRWPIAVVLVSIATTPAEMGFLMALVGLYTLAASEVPRRITVVLAGMSLVGTFIVTYVRLRQSVAEQADFGPGDWYVPVVSVFMSVGLTAPSVLFGLYIGARRRLMESLRERADSLERELSLLADRAEERAEWARTEERTRIAREMHDVVAHRVSLMVVHAAALQAVAPKDPAKAVRNAALVGDMGRQALTELREMLGVLRSGDALIAPAAAGGGAVPLAAVGQAAAAAAAAAASEDGPRLSELEALVAQSRQAGMVVELSVDGELRPYAPEVEQTAFRVVQEALTNVHKHAAGAKTWVRLAHRGVEVAMQVENGPSDAAVADAGLPSGGNGLVGMRERVLALGGVFVSGPTDAGGFRVSAVLPDASSVAIPGASGV
>NC_021177.1|WP_015609051.1|3124628_3125501_+|hypothetical-protein
MTETTSKYADFEGLRAQAVALRREGLSRRQIRDRLHVDNNDLLNRLLQGEPAPEWTKRPRAKDDLREKARELRLQGMTYDQIQVELGCSKSSISLWVRDLPKPAPRTREEASAIAKRGWEVILQRREQERREVKRSAQDEIGSLSERELFLLGVGLYWAEGTKDKPHARRERVAFVNSDPSMIQIFLAWLSLLDIAPARLRFHVMIHESADVGSAERYWAGLTGTDFSTFGKTTLKKHNPRTNRKNVGESYRGCLVINVQQSADLYRRIEGWWCGIVGGSVFGHGQSLPG
>NC_021177.1|WP_015609052.1|3125688_3127137_+|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MSATSPAAVVVLAAGEGTRMKSKTPKVLHEISGRSLVGHVVAAARELDPQHLVVVVGHASEQVTAHLNAGDAPVRTAFQAEQNGTGHAVRMGLEELGGAVDGTVIVVCGDTPLLSGETLGALAATHAADANAVTVLTAEVPDSTGYGRIVRDPASGAVTEIVEHKDATDEQRAILEINSGVFAFDGSLLADALGKVRTDNSQGEEYLTDVLSILREAGHRVGASVAGDHREILGINNRLQLAQARRLLNERLLERAMLAGVTVVDPASTLIDATVTYERDAVVHPGTQLLGTTHLAEDSEVGPNSRIADTSVGAGARVDNSVTDSAEVGPGALVGPYAYLRPGTRLGTKSKAGTYVEMKNATIGEGTKVPHLSYVGDATIGDHTNIGAASVFVNYDGVAKHHTTIGSHCRTGSDNMFVAPVTVGDGVYTAAGSVITKDVPSGSLAVARGQQRNIEGWVARKRPGSAAAQAAQASSQEHDGQS
>NC_021177.1|WP_015609053.1|3127256_3128234_+|ribose-phosphate-diphosphokinase
MTGIKTTGEKKLMLFSGRAHPELAEEVAHQLGVGLVPTKAFDFANGEIYVRFQESARGADCFLIQSHTAPINKWIMEQLIMLDALKRASARSITVIVPFYGYARQDKKHRGREPISARMVADLMATAGADRILTVDLHTDQIQGFFDGPVDHLFALPILADYVGAKVDRSKLTIVSPDAGRVRVADRWCDRLDAPLAIVHKRRDKDVPNQVSVHEVVGNVEGRVCVLVDDMIDTGGTICAAADALFAHGAEDVIVTATHGVLSGPAADRLKNSKVSEFVFTDTLPTPGELELDKITVLSIAPTIARAVREVFEDGSVTSLFEEQG
>NC_021177.1|WP_015609054.1|3128442_3129027_+|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MAEIKLAAEVRTEFGKGAARRTRRANQVPAVIYGHGAESVHITLPGHELQLALRTANVLIGLEIDGKDALVIPKAVQRHPLKGTIEHVDLLTVKRGEKVNVEIAVHAEGDLAPGANLLEFVLNTLLVEAEATHIPESVTVSVAGLDAGDSIVAKDIPLPKGSVLAGDEDAIVIQVVAAQAEEPSADAETETVEA
>NC_021177.1|WP_015609055.1|3129170_3129764_+|aminoacyl-tRNA-hydrolase
MSDATDPWLIVGLGNPGPEYAANRHNVGFMVADLLATRIGGKFKRAQKAQAQVVEGRIGPPGPGSRRVVLAKPMSYMNLSGGPVTALRDFYKVPLDHVVAVHDELDIDYGMLRLKLGGGDNGHNGLKSMTKSMGPDYHRVRFGIGRPPGRMQVADFVLKDFGSVERKELAFLVDRAADAVECLLAEGLERAQSAYNS
>NC_021177.1|WP_015609056.1|3129880_3130351_+|hypothetical-protein
MKRSSSQRAALVGRRTAMGLVALVLLVAGVWSSWDAAHHVVLAQGREHGTLTVTECGEETCTGRYEPDATSSARARVVVERSVAAEKGDRFPVVVKPGSDVVVRTGMPGFLHAWTPLGGALVLAGFVIGGGLRMTRTAWGVGTAGAVLLVATFVAL
>NC_021177.1|WP_015609057.1|3130389_3133119_-|phosphoenolpyruvate-carboxylase
MSSADQTPAASPELRADIRRLGDLLGETLVRQEGQELLDLVERVRALTRTDGEAAATLLGDTDLETAAQLVRAFSTYFHLANVTEQVHRAHEMRDRRAAEGGLLARTADRLKDADPEHLRATVKNLNVRPVFTAHPTEAARRSVLNKLRRIAELLETPVIEADRRRHDLRLAENIDLIWQTDELRVVRPEPADEARNAIYYLDELHANAVGDVLEDLAAELERVGVELPAGTRPLTFGTWIGGDRDGNPNVTPAVTWDVLILQHEHGITDALELIDYLRGLLSNSIRYTGATDELLTSLQADLERLPEISPRYKRLNAEEPYRLKATCIRQKLVNTRERLAKGTPHRPGCDYLGTSQLIADLELIQTSLREHKGGLFADGRMDRTIRTLAAFGLQLATMDVREHADAHHHALGQLFDRLGEESWRYADMPRDYRQKLLAKELRSRRPLAPTPAPLDAAGEKTLGVFHTIKEAFERFGPEVIESYIISMCQGADDVFAAAVLAREAGLVDLHAGWAKIGIVPLLETTDELKAADVILDEMLADPSYRRLVSLRGDVQEVMLGYSDSSKFGGITTSQWEIHRAQRRLRDVAHRYGVRLRLFHGRGGTVGRGGGPSHDAILAQPWGTLEGEIKVTEQGEVISDKYLIPALARENLELTVAATLQASALHTAPRQSDEALARWDAAMDTVSDAAHGAYRKLVEDPDLPAYFLASTPVDQLADLHLGSRPSRRPGSGVSLDGLRAIPWVFGWTQSRQIVPGWYGVGSGLKALREAGLDTVLDEMHEQWHFFRNFLSNVEMTLAKTDLRIARHYVDTLVPDELKHVFDAIEAEHALTVQEVLKVTGSTQLLGTSPVLQQTFAIRDAYLDPISYLQVSLLARQRQAVERGEEADPLLARALLLTVNGVAAGLRNTG
>NC_021177.1|WP_015609058.1|3133510_3134512_+|fatty-acid-desaturase-(membrane)
MPSTPDVIDESGPSAAGATPTATATLPPATLGGEKKRSIEQFALLAFIVVPFVALLAAVPLVWGWGVSWLDVGLMVAMYFIGCHGITIGFHRYFTHGSFKAKRPLRIALAVMGSLAVEGPLVRWVADHRKHHRFSDAEGDPHSPWRFGETLPALMKGLWWAHIAWMFDEEQTPQQKYAPDLIRDPAIRGISRHFLSFTIVSLAIPPLVGGLVTMSWWGAATAFFWGSLVRVALLHHVTWSINSICHAVGKRPFKSRDRSGNVWWLAVLSCGESWHNLHHADPTSARHGVMRGQIDSSARLIRWFEQLGWASDVRWPDAARIDARRTPVPADPA
>NC_021177.1|WP_015609059.1|3134508_3135189_+|TetR/AcrR-family-transcriptional-regulator
MIDDVATDGSSEKSRPTASRRARRVRMTGKERREQLLDIGRALFADKGFEGTSVEEIAARAGVSKPVVYEHFGGKEGLYAVVVDREMRRLLDMVQGALTAGHPRELLEQAAFALLDYIESYTDGFRILVRDSPVAQSTGTFASLISDIATQVEDILGLEFKARGFDPKLAPLYAQALVGMVALTGQWWLDVRKPKKAEVAAHLVNLCWHGLENLESKPRLIGHRKS

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Crispr_ID: NC_021177_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_8

3690954-3691036

Orphan

Consensus_repeat	Method
ACCCCGCCCAGCACACCGCCGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_8

>merge|NC_021177|8|3690954-3691036|CRISPRCasFinder
ACGCCGCCGAGCACCCCGCCCAGCACACCGCCGGTTCCGCCGGTCGTACCGCCGGTCAGGACGCCGCCGAGGACCCCGCCCAG

>NC_021177|8|8|3690954-3691036|CRISPRCasFinder
ACGCCGCCGAGCACCCCGCCCAG	CACACCGCCGGTTCCGCCGGTCGTACCGCCGGTCAGG
ACGCCGCCGAGGACCCCGCCCAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_164711328.1\|3686627_3687047_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015609542.1\|3697392_3698277_-\|chitinase	unknown	unknown	gnl\|CDD\|381595
NC_021177.1\|WP_015609533.1\|3687212_3688049_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_021177.1\|WP_015609531.1\|3686032_3686671_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|181904
NC_021177.1\|WP_043974556.1\|3684298_3685393_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|275041
NC_021177.1\|WP_015609534.1\|3688045_3688282_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NC_021177.1\|WP_015609547.1\|3703133_3704417_-\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NC_021177.1\|WP_043974562.1\|3699052_3700123_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|173833
NC_021177.1\|WP_015609543.1\|3698706_3699060_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015609541.1\|3696161_3697304_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|236089
NC_021177.1\|WP_106960228.1\|3689875_3690502_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015609548.1\|3704603_3705455_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366301
NC_021177.1\|WP_015609536.1\|3688731_3689883_-\|HTTM-domain-containing-protein	unknown	unknown	gnl\|CDD\|214802
NC_021177.1\|WP_015609527.1\|3683485_3684028_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225767
NC_021177.1\|WP_015609545.1\|3700165_3701359_+\|DUF2236-domain-containing-protein	unknown	unknown	gnl\|CDD\|378343
NC_021177.1\|WP_078618691.1\|3694319_3695828_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NC_021177.1\|WP_015609539.1\|3692316_3694311_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375647
NC_021177.1\|WP_015609535.1\|3688333_3688735_+\|DUF393-domain-containing-protein	unknown	unknown	gnl\|CDD\|367833
NC_021177.1\|WP_015609546.1\|3701489_3703019_+\|solute-binding-protein	unknown	unknown	gnl\|CDD\|270371
NC_021177.1\|WP_015609530.1\|3685400_3685871_-\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|376622

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015609542.1\|3697392_3698277_-\|chitinase	gnl\|CDD\|381595	cd00325, chitinase_GH19, Glycoside hydrolase family 19, chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Glycoside hydrolase family 19 chitinases are found primarily in plants (classes I, III, and IV), but some are found in bacteria. Class I and II chitinases are similar in their catalytic domains. Class I chitinases have an N-terminal cysteine-rich, chitin-binding domain which is separated from the catalytic domain by a proline and glycine-rich hinge region. Class II chitinases lack both the chitin-binding domain and the hinge region. Class IV chitinases are similar to class I chitinases, but they are smaller in size due to certain deletions. Despite lacking any significant sequence homology with lysozymes, structural analysis reveals that family 19 chitinases, together with family 46 chitosanases, are similar to several lysozymes including those from T4-phage and from goose. The structures reveal that the different enzyme groups arose from a common ancestor glycohydrolase antecedent to the prokaryotic/eukaryotic divergence.	5.0435e-82
NC_021177.1\|WP_015609533.1\|3687212_3688049_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	0.00145639
NC_021177.1\|WP_015609531.1\|3686032_3686671_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|181904	PRK09491, rimI, ribosomal-protein-alanine N-acetyltransferase; Provisional.	3.41473e-09
NC_021177.1\|WP_043974556.1\|3684298_3685393_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	4.61215e-65
NC_021177.1\|WP_015609534.1\|3688045_3688282_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	8.19194e-18
NC_021177.1\|WP_015609547.1\|3703133_3704417_-\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NC_021177.1\|WP_043974562.1\|3699052_3700123_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	1.119e-57
NC_021177.1\|WP_015609535.1\|3688333_3688735_+\|DUF393-domain-containing-protein	gnl\|CDD\|367833	pfam04134, DUF393, Protein of unknown function, DUF393. Members of this family have two highly conserved cysteine residues near their N-terminus. The function of these proteins is unknown.	2.34032e-21
NC_021177.1\|WP_015609545.1\|3700165_3701359_+\|DUF2236-domain-containing-protein	gnl\|CDD\|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	2.52034e-17
NC_021177.1\|WP_015609548.1\|3704603_3705455_+\|hypothetical-protein	gnl\|CDD\|366301	pfam00781, DAGK_cat, Diacylglycerol kinase catalytic domain. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.	7.23902e-05
NC_021177.1\|WP_015609536.1\|3688731_3689883_-\|HTTM-domain-containing-protein	gnl\|CDD\|214802	smart00752, HTTM, Horizontally Transferred TransMembrane Domain. Sequence analysis of vitamin K dependent gamma-carboxylases (VKGC) revealed the presence of a novel domain, HTTM (Horizontally Transferred TransMembrane) in its N-terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is more likely caused by horizontal gene transfer than by early invention. The conservation of VKGC catalytic sites indicates an enzymatic function also for the other family members.	8.94379e-70
NC_021177.1\|WP_015609527.1\|3683485_3684028_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|225767	COG3226, COG3226, Uncharacterized protein conserved in bacteria [Function unknown].	3.40887e-30
NC_021177.1\|WP_078618691.1\|3694319_3695828_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	2.84788e-08
NC_021177.1\|WP_015609539.1\|3692316_3694311_+\|hypothetical-protein	gnl\|CDD\|375647	pfam18220, BspA_v, Adhesin BspA variable domain. This domain is found in BspA protein present in Streptococcus agalactiae. BspA is an antigen I/II family polypeptide that confers adhesion linked to pathogenesis in group B Streptococcus. This domain is referred to as the variable domain (BspA-V). BspA-V is responsible for binding to scavenger receptor gp340. BspA-V adopts a fold that is distinct from those of other AgI/II family polypeptide variable domains.	0.0092874
NC_021177.1\|WP_015609541.1\|3696161_3697304_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|236089	PRK07761, PRK07761, DNA polymerase III subunit beta; Validated.	2.95359e-158
NC_021177.1\|WP_015609546.1\|3701489_3703019_+\|solute-binding-protein	gnl\|CDD\|270371	cd13653, PBP2_phosphate_like_1, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.30083e-48
NC_021177.1\|WP_015609530.1\|3685400_3685871_-\|hemerythrin-domain-containing-protein	gnl\|CDD\|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	4.4763e-09

>NC_021177.1|WP_106960228.1|3689875_3690502_-|hypothetical-protein
MGGVTTEHVRRRVLNTAVALCLTTALAHVGLVFLHVAPSNVVSQRFNSQVDAWIYPFFEQNWRLFAPDPDSVNREISARTAHTAPDGSIEVSDWVDLTAVDASAIRHNPLPSHTAQNMLRRSWTSYVELHGGDDLSRSDRAVMMQQYLRNIAADRMAERDGKPFENIQLRVVTLPVPAQGSADGDRRAAAAKNSDTRLLPWWKVASDA
>NC_021177.1|WP_015609536.1|3688731_3689883_-|HTTM-domain-containing-protein
MPEPTNSPTRPAVRVTGAARDAWALLTDRPLSLYAVSVLRIGYGLLYLVFLLREFPHRDAIWGPGSPWTPDLARQLFDQTGWVSVLTLSDSRLYFELCYAAALVVSVLFLLGWRTRAVSVLFAVVVASFHARSIFMTDGGDNLVLLMALYLVLTACGRRWSLDARRARRTPARRRRLPVLPPQLASARDALVTTVHNCGLLVIGVQVCFLYGAAGLYKVQGGTWGAGTALHYVLNLDLFQPWPALSHWADDQALAIAVVGYLTVLLQVAFPFVLFGRLKYPVLTMLFGMHIGIAVLMGLPLFSGAMIIADAVFLPDRFWIAAGRLARRALGRTEEPQPTAAGAPEGPEGPEGPEASATPEVSEPPRGAVPKQGGRVAPVRDRP
>NC_021177.1|WP_015609535.1|3688333_3688735_+|DUF393-domain-containing-protein
MSTQPVLVYDGDCAFCTTSVNFLTRYVRPQCTVTPWQFADLDALGVTQERAEHEVLWISPLGTVYGGAQAVAKLLLRAGGGWAWLGGLLTLPPVRWIAHGVYRLVAANRTRMPGGSPACALPADRRPGVRSAP
>NC_021177.1|WP_015609534.1|3688045_3688282_+|DUF397-domain-containing-protein
MSSTLRWFTSSYSSDSGGECIEVAIEWRTSSYSSDSGGNCVEVASCPHSVHVRDSKVTDGPAFAVAPDAWSAFVTWAD
>NC_021177.1|WP_015609533.1|3687212_3688049_+|helix-turn-helix-transcriptional-regulator
MASAENKESASPTAQMVAEVARTMRIQRGWTQEQEGQELGYSAAAVSAMETCAQPASDAMLVELERVLGNGTGIFLTARRYMRMERLPQQFQDYALLEQDAISLQLFVTNVVHGLFQTEAYARALIGGGCPPLSDERVEELVQLRMERTALFDRDPLPMIEVIIDEAVLRRVIGSEEIMREQLLYLVECARRRNVTLLVLPLDAGKYGEYAGARGAMTLVETPAHEHLVYLEPQDDSLLISDPAKVSIYAQRYAKIRSQALGPRESLDLIKRLAGVKE
>NC_021177.1|WP_164711328.1|3686627_3687047_-|hypothetical-protein
MNDECERNIEWLPVSGFQLRKAGVQFDAVRVDGDAGRRLADLMEELVGGEPGPVVAEANGRRGVYFFVPPGSTAHRCWPREVTILNATRNRVSYVPVPALEGRTWPLSWRYPPTAPDRFVHTLILINAAESLLYSGRDR
>NC_021177.1|WP_015609531.1|3686032_3686671_+|GNAT-family-N-acetyltransferase
MTRPAGILRPYRPEDRDALFDICVRTGHEGGDSRHLYPDPDLLPNIFAAPYAVLEPELAFVVEDGGRAVGYIVGTADTASFVARYRTEWLPGLTGRYPAPVQPQDPATPAEMMTGLMHDPERMMLPELDGYPAHLHIDLLPSHQRYGYGRALMETFLGALHPRGVPAVHLSMVTSNTPARAFYDRVGFHEIAVPDPRPVTYLGRSTAGTPPR
>NC_021177.1|WP_015609530.1|3685400_3685871_-|hemerythrin-domain-containing-protein
MTERETTRLVAWHQELRRVHHRLREALDVTRAALDEGIPGESATRELLLYCHGFCAALDSHHEGEDRTLFPAIAAAHPELRPVLRSLEQDHSMIAHLLGGLSAAVDRAASPEELDGHLEGIAALMENHFRYEERQLLAVLETLELSAAPGEVLGPL
>NC_021177.1|WP_043974556.1|3684298_3685393_+|methyltransferase-domain-containing-protein
MTDGGLWPADSPWVRRAVESTPRDRFAPDTVWAWTGGERYRAVNRAEAPEAWAAEVYPDPYGSTVTQVTDSMPTSSISCAAIVATMLDSLVLEPGHRVLELGTGSGWNAALLAERTGQGHVTSVEIDAGLAAHARRRVEAAGHRVRVITGDGGAESVEHAAFDRVISTYAVEHVPWTWVERTRPGGRIVTPWGHTGCVALTVAQDGASATGWMQAPARFMPTRRSGHPPSPFERVRDGGTGVPTAFSRPVQALSHPDVLFALRVLLPDVHIDTQVAGTGGQLTAWLSDGRSSWAVLEQVGNAVNAHGGGGRDLADEVSRAWAVWEERGSPGMYDFGLHITPDAHHVFTGDDPHRPRWQPLVAAP
>NC_021177.1|WP_015609527.1|3683485_3684028_+|TetR-family-transcriptional-regulator
MATGRTDPDRRDRIIDAALDLIADEGVAGISHRKVAARAGVPLGSMTYHFASMDELLHEAFTRFSGTIVAVFEDRLGAAATPDEAREAVADLVHHLSGGNQRELILTHELYTLAARKPAYRELTREWMSRSRRALEWHFDAATARQLDALIEGLSIHRALETEPHDRALTVEAIARITTP
>NC_021177.1|WP_015609539.1|3692316_3694311_+|hypothetical-protein
MRTRRISTATAFAVLFSSVVLVGGAANPAAADSSRILPATSLGDIVADGVHQRVFISDPQSGQILATDYSGKVVRVLGELPGVNGLELSADSGTLYAGVASSDYIVAIDTATLTESARYDIGLGTRPTHPALAGGKLWFGYGAAAEGNIGSLDLSGEEPVVTLDQDPDRTWYSAPVLASSPGAPGTLAAGIEGQSPSELAVYDVASGSAERTAYLRADASNLRDIAVSPDGAQLVVASGAPYFHQVYRTSDLRAEQGYTSDAYPTAVDIAPNGTVAAGIDGSYDPDVYIYPKGGSKTVPVREYELPSTGTSSGSDLLEPAGLAWAPDGSRLFAVSVNSEGVRSFRVLTDPTKSVAGLSVSAPATATRGKALTVKGSIKASVALPAGTPLTVTRTDVESPKGKSLGTVKTDAKGAFTFTNTPPVGGKVTYRVAYAGSATHTAASGSAAVTVSRAAVSLKLNRNKSLHAYNKNVSFTATLGKTYKNRVVELWADPFGADKPKKLVKKAKVNSKGNLSVTVNMKRDTTVTAVFAGDGRYAPKTVKSTAYAKVNVSTKLSKHYKTGKIGKTSYAYYSKKKNPDFTTTMTYYKGRAQRLSLELYYKGKWYDAGQQYFPLGTKGKSIVTLTGPHDTGYKMRVRSSYVNSSSGDTVNSTTHGAWKYFIFTK
>NC_021177.1|WP_078618691.1|3694319_3695828_-|helix-turn-helix-domain-containing-protein
MQRLARNGGTAELLRWLSGRADGWAGIAGSDGTVLSASGTVAPDVPQPPDVPRLVADGVRALAERGALAYSHDTGAHTALLFPLYADDRGAAPLLAVVTPRPVAAGLATLLADVLMPLSLCWEAEAVERKRRRVDLAESRGREAVLHLLMTGQLSIARQVAGALRPRLPDPVRVCVVECPGGSRDEVARVCAEADGGRSWIVRCPVYARHLILVMPAEEAPEGTATDEAVAALVDHCVVGVSEQVPLADTATGYRQAFHALAVAREHPARHVRFGLTPEPALVVGRAGRQWAEALLTPLLTHVPRRAQDPGSQELAATAASWLAFSSHATGHLKVHRNTLAARLKLIGELLGLDLHRLADQSALDLALRIRATPAPVCTPDPGEPARTADSAHADGTAAPAHANGAAHDLDEVLRRPAVQEWAARQLAPMTGPAGPAAEETLRAWLGCEGRLGPTAAELGISVPGARKRLTRLETVLQRSLLRPPSARYDLWLALRAQEVKP
>NC_021177.1|WP_015609541.1|3696161_3697304_+|DNA-polymerase-III-subunit-beta
MEFRIERSALTEAVAWAARVLPVRSPVPVLGGLLLDTEGGRLRVSGLDYEASARIDVEAAEILRPGKVLVMGRRLLDICKVLPDGPVECAVEGSRFTVSGDGARFGLSVLPLADYPALPSLPQVRGAVDAAEFAAAVADVAVAAGRDDTLPALTGIRLGLDGETGTMTLAATDRYRFAVRTLPWKATAGDPGPDRSADVSADVIVSARRLTEIARSLGRSGLVSVALDAGSAGFEHAGMRTTVRLLEGRLPRHDKLFALESPAVAVVDRARLVEAVKRVSVVADGDSPVQMSFSAADNSVLLQAGYEDDVASQRLPATLEGAREMTVAFNPGYLADALASFDEPALRLLLMGAGQRAMITGESEPDAHRHLLMSVKPPLM
>NC_021177.1|WP_015609542.1|3697392_3698277_-|chitinase
MIRRVMSLLVALAALVAMLVVLPAATAQAANCNTAWSSSSVYVGGQTASYNGRNYTAKWWTQNERPGSSDVWADNGACGTGGGGEQPGTGFVVSEAQFNQMFPSRNSFYTYSGLTAALSAYPAFANTGSAELKKREAAAFLANVSHETGGLVYIKEVNEANYPHYCDTSQSYGCPAGQAAYYGRGPIQLSWNFNYKAAGDALGINLLANPYLVEQNASVAWKTGLWYWNTQNGPGTMTAHNAIVNGAGFGETIRSINGSIECNGGNPAQVQSRINKFTQFTQILGTTTGSNLSC
>NC_021177.1|WP_015609543.1|3698706_3699060_+|hypothetical-protein
MERTRDTGKGVGGPGEQAVLLAAGIADLAVTTVGAAFTSVRGLLRRSDTAELAAEAEQDLIARGRLALDRYTTAPPAHLEVLARHVIAQRDGDRAGDDNRAGDRDRTGDGDRIGDRA
>NC_021177.1|WP_043974562.1|3699052_3700123_+|polyprenyl-synthetase-family-protein
MPEAWEPGSFKARVDQVLHRFAAAEADQLTAIDSSLGPVADAVETAVADGKRLRAAFCYWGWRAAGQPDSDALVRAAASMELVHAAAVVHDDLIDDSPLRHGRPTAHLALREAVKDHPEPALAARSLAMLAGDLLMSMAGQLFVTSGLPAAYLSRARPLWAALARELVAGECLEILHTGAAAPDTATSLKVVRYKTAKYTVEQPLLIGALLGGAGERLREGCSAYGLPLGEAFQLRDDLLGLFGDPELTGKDGSDDVRGHRPTALLSETWRLAGEEDRARLRTLLAPGAETRTADTANPADAVREVMRRLKAPDRIEDMITARVEEALRALDELDLPGPAATALTGLAHSAAVRRS
>NC_021177.1|WP_015609545.1|3700165_3701359_+|DUF2236-domain-containing-protein
MTYTQASLDALRQGGDELADATVATLFERGEVGTFNTLMRYVSTAGAPLPDGLPDVAREYLDATAAPPSWVDWGEMEKARLFFIDNNVHISTALSFASMPACYVVPHVAKLLSATHGLSYPSKRMAETGQFTVYLMQPDAFEAGSRFIPAAQKVRLLHASIRHHLRREGVWDVESAGVPICQEDMIGGQMFFSMLVLDSLHRLGIHMSEEGADAYYYAWRVVGAMLGVDQDAVPKTLAEAREFLDLYMIRHMGPSAEGALLTRQLIDLYEEIVPGTLFDPIVSALIRHLVGDTCADWLEVPRTPWDTVAKAVPHLLGVLETIEDRSPLGAWALDRIGHLTSVLELSSLTRGRVMHYAIPEHLKKEYGVPSGPARTGRWSPPAATVPGPRQGGVPTAF
>NC_021177.1|WP_015609546.1|3701489_3703019_+|solute-binding-protein
MEWFSAENVVAVLTAVLGVLASIGVLWYERRVPRRKRIGYRVQMDTPIGSDVSQGRANVRLGLFSETPDMSDATLVLLRVENDGSQSIVDSDYTGRELHGLTAEFTGRTVRGIAVTQPPGAVHLMEHFTPAAGMRHSGSLIRLPRVPLNRGEHFKLLVLLTGADVGSPIRITGGIRDGEVTVNRAARPDDKPPLFGRAARLITVSLTVCVVVLAAIILVRDDTPPPLDCARGELRVTGSTAFAPVVRELAATYMEECEGSRIEVDPRGSNSGIRELSDEGARAGKSGSPALVALSDGPKPPGHPELRETRVAVSLFSLVVNDRVPVRDLSLADIRRVYAGEIRNWRELGGPDLEILLVSRDANSGTREVFQRRVLDRNEPAQSSRDCATKDDPRAPVVRCELDGTDQVLATVARLDGALGYSELRSGSEPRGLHRISIDGAEPSVDTIGTSTYPYREIEYAYTYGRPPADSLASGFLGYLSRGRGQDVIQVHGHLPCATPKGLRVCGED
>NC_021177.1|WP_015609547.1|3703133_3704417_-|adenylosuccinate-synthase
MPALVLLGAQWGDEGKGKATDLLGGSVDYVVRYQGGNNAGHTVVVGDQKYALHLLPSGILSPGCTPVIGNGVVVDPAVLLSELSGLNERGVDTSKLLISGNAHLITPYNVTLDKVTERFLGKRKIGTTGRGIGPTYADKINRVGIRVQDLYDESILEQKVEAALEQKNQLLAKVFNRRAIEAGKVVEDMLQYAEQIKPFVADTTLILNDAIDEGKVVLFEGGQGTLLDVDHGTYPFVTSSNPTAGGACTGAGVGPTKISRVIGILKAYTTRVGAGPFPTELHDADGEALRRIGGERGVTTGRDRRCGWFDAPIARYATRVNGLTDFFLTKLDVLTGWEQIPVCVAYEIDGKRVEELPYNQTDFHHAKPIYENLPGWSEDITKAQTFDDLPKNAKAYVKALEEMSGAPISAIGVGPGRTETIQINSFL
>NC_021177.1|WP_015609548.1|3704603_3705455_+|hypothetical-protein
MSAAEPPGDGDDQLLVVIDPVARRTDGESVRIAKDVLSAGSHAKICLPDTPEEFARALSRRGSRRPVVVGDDHALLRAVAQLHRERELAAGVLSLIPVGAAHALEVAHALGVPRGAVAAARTALDGAVRRLDLLVDDSDGVVLGRLCIPAPTLLADAPHTGVTAVWDTCRSLMTSLVRPAAPGASGGPQGTYRLRVEADGVLLSDLDAPVRGVSVHSQGGGGLADVVVRTSDGEEVTAEAKAVTVSGADFRYRADIQTGGPVRTRTWTVRAGAWGLMLPVPAS

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Crispr_ID: NC_021177_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_9

3889695-3889804

Orphan

Consensus_repeat	Method
CAGCCCGTCCGGCGTTTGAGGACGGGACCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_9

>merge|NC_021177|9|3889695-3889804|CRISPRCasFinder
CAGCCCGTCCGGCGTTTGAGGACGGGACCCTCGGTCGGAGGGGCCGGGCCCTTCTCAGGCCCGGGGGGCGGGCCGTTGTCAGCCCGTCCGGCGTTTGAGGACGGAACCCT

>NC_021177|9|9|3889695-3889804|CRISPRCasFinder
CAGCCCGTCCGGCGTTTGAGGACGGGACCCT	CGGTCGGAGGGGCCGGGCCCTTCTCAGGCCCGGGGGGCGGGCCGTTGT
CAGCCCGTCCGGCGTTTGAGGACGGAACCCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015609724.1\|3905314_3906172_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NC_021177.1\|WP_015609717.1\|3897138_3898239_-\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
NC_021177.1\|WP_015609709.1\|3882709_3883180_+\|cation:proton-antiporter-regulatory-subunit	unknown	unknown	gnl\|CDD\|223564
NC_021177.1\|WP_015609716.1\|3895115_3897122_+\|TrkA-N-domain-protein	unknown	unknown	gnl\|CDD\|367001
NC_021177.1\|WP_015609703.1\|3878294_3879071_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381314
NC_021177.1\|WP_015609722.1\|3901349_3901772_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NC_021177.1\|WP_043972576.1\|3901866_3905235_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226415
NC_021177.1\|WP_015609707.1\|3881352_3881685_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015609706.1\|3880592_3881138_+\|flavoprotein	unknown	unknown	gnl\|CDD\|376786
NC_021177.1\|WP_015609720.1\|3899429_3900542_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274934
NC_021177.1\|WP_015609713.1\|3886674_3887349_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377769
NC_021177.1\|WP_015609721.1\|3900547_3901207_+\|FMN-reductase	unknown	unknown	gnl\|CDD\|274935
NC_021177.1\|WP_015609712.1\|3885158_3886232_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225306
NC_021177.1\|WP_015609711.1\|3884672_3885128_+\|TerB-family-tellurite-resistance-protein	unknown	unknown	gnl\|CDD\|377455
NC_021177.1\|WP_015609708.1\|3881882_3882440_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015609710.1\|3883182_3884460_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NC_021177.1\|WP_015609705.1\|3880143_3880596_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240026
NC_021177.1\|WP_015609715.1\|3890075_3895085_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|378861
NC_021177.1\|WP_015609725.1\|3906168_3907140_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NC_021177.1\|WP_164711287.1\|3898511_3898652_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015609724.1\|3905314_3906172_-\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	4.14564e-21
NC_021177.1\|WP_015609717.1\|3897138_3898239_-\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	2.00037e-120
NC_021177.1\|WP_015609709.1\|3882709_3883180_+\|cation:proton-antiporter-regulatory-subunit	gnl\|CDD\|223564	COG0490, COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism].	4.92504e-38
NC_021177.1\|WP_015609716.1\|3895115_3897122_+\|TrkA-N-domain-protein	gnl\|CDD\|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	2.25464e-20
NC_021177.1\|WP_015609703.1\|3878294_3879071_+\|aldo/keto-reductase	gnl\|CDD\|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	1.14478e-97
NC_021177.1\|WP_043972576.1\|3901866_3905235_+\|AAA-family-ATPase	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	2.24031e-36
NC_021177.1\|WP_015609722.1\|3901349_3901772_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.38858e-28
NC_021177.1\|WP_015609706.1\|3880592_3881138_+\|flavoprotein	gnl\|CDD\|376786	pfam02441, Flavoprotein, Flavoprotein. This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD, which has been shown to be a flavoprotein that binds FMN. This enzyme catalyzes the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance. dipicolinate synthase catalyzes the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase (EC:4.1.1.-).	2.26342e-13
NC_021177.1\|WP_015609713.1\|3886674_3887349_+\|hypothetical-protein	gnl\|CDD\|377769	pfam07077, DUF1345, Protein of unknown function (DUF1345). This family consists of several hypothetical bacterial proteins of around 230 residues in length. The function of this family is unknown.	0.00130213
NC_021177.1\|WP_015609721.1\|3900547_3901207_+\|FMN-reductase	gnl\|CDD\|274935	TIGR04037, predicted_flavoprotein, LLM-partnered FMN reductase, CE1759 family. This family represents a distinct clade within pfam03358. That family includes enzymes such as the NADH-dependent FMN reductase MsuE. Members of the present family regularly co-occur in genomes, typically as gene pairs, with members of TIGR04036, a probable FMN-dependent member of the bacterial luciferase-like monooxygenase (LLM) family. At least one member, RF\|YP_001509627.1 from Frankia sp. EAN1pec, is fused to the LLM protein. The function of these gene pairs is unknown.	6.65116e-91
NC_021177.1\|WP_015609712.1\|3885158_3886232_-\|hypothetical-protein	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	9.48232e-15
NC_021177.1\|WP_015609711.1\|3884672_3885128_+\|TerB-family-tellurite-resistance-protein	gnl\|CDD\|377455	pfam05099, TerB, Tellurite resistance protein TerB. This family contains the TerB tellurite resistance proteins from a a number of bacteria.	1.77384e-26
NC_021177.1\|WP_015609720.1\|3899429_3900542_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274934	TIGR04036, family_protein, putative luciferase-like monooxygenase, FMN-dependent, CE1758 family. This tightly conserved subfamily of the bacterial luciferase-like monooxygenase (LLM) family, with members showing > 60 % pairwise sequence identity, includes proteins from both species with and species without the ability to make coenzyme F420. Therefore, the like cofactor is FMN rather than F420. The presence of three members in Kineococcus radiotolerans SRS30216 and two in Saccharopolyspora erythraea NRRL 2338 suggest closely related (subfamily) rather than exactly conserved (equivalog) function. Gene neighborhoods around members are not conserved. [Unknown function, Enzymes of unknown specificity].	0
NC_021177.1\|WP_015609710.1\|3883182_3884460_+\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	2.45493e-54
NC_021177.1\|WP_015609705.1\|3880143_3880596_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240026	cd04669, Nudix_Hydrolase_11, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	6.68925e-13
NC_021177.1\|WP_015609715.1\|3890075_3895085_+\|AAA-family-ATPase	gnl\|CDD\|378861	pfam12458, DUF3686, ATPase involved in DNA repair. This domain family is found in bacteria, and is approximately 450 amino acids in length. There are two conserved sequence motifs: DVF and SPNGED.	0
NC_021177.1\|WP_015609725.1\|3906168_3907140_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	1.90804e-130

>NC_021177.1|WP_015609713.1|3886674_3887349_+|hypothetical-protein
MDEFLNAALGFPAVIFGAALVVVVCFWLLVLAGAADQHSFDSDLDPGTVGFGGVPVTVSVSLLVVVAWFGSLTGTVLLHQVPATGALRAVLAIAVLAGSLFLAWGTVRLLAHLFRRYFPAEPPPSRKDFVGRVCTVRTGSVSASFGQAEVASADGSTAIVQVRQAPRAELLAELHAEELLVSGSTGLLYAYDEEGEFFWVSPYDAALDPGPEAKPGGLPENMNG
>NC_021177.1|WP_015609712.1|3885158_3886232_-|hypothetical-protein
MAEPTIPQEMLGNYAHILGEVATTGRRLTRNELEMRRALGREAADAGHQLRALVTMHLAQTREAWPRAAAGNSPAVADAVLAAVEQAVDAFAEGFERAQRLTVRREEAARREFIDDLLYGRSDLVRLAERATRFGLRLSRAHAVAVASGPEAYTETDAVPRSVEAALLARFSGRKILLTTKDGRIVCIAPGSQPDVLRYFAKQSHAATDGGQVAVGRPHKGPGGVVHSYDEALEALDLAERMGMDDPVLYASDLLVYPVLTRDRQAMADLVRSELGPLQKARGGAEPLLKTLAVYFDAGCVAAETARRLALSVRALTYRLERIHQLTGSDPADPMHRYSLQTAVIGARLLDWPAKEL
>NC_021177.1|WP_015609711.1|3884672_3885128_+|TerB-family-tellurite-resistance-protein
MALWDRIKESASSMQTQLEAKKNDLKSGAFRDASMAMCALVAAADGTIDPSERQRVAALIASNDVLQNFPADDLQRRFNDYVNKLTADFAFGKVSVLQEIAKAKKKPAEARAVIQIGIIIGGADGDFDKTEQAVVREACFALDLPPHEFDL
>NC_021177.1|WP_015609710.1|3883182_3884460_+|cation:proton-antiporter
MHDTTALLVELGAVILGLGLIGRVAGRIGLSPIPLYLLAGLAFGHGGLIPLDASEEFTMVGAEIGVILLLLLLGLEYSASELVTSLKTQYPSGAVDFVLNATPGAVAALILGWGPVGAVALAGVTWISSSGVIAKVMTDLGRLGNRETPVILGVLVMEDLAMAVYLPLLTAMLAGVSLAGGSLALLIALGTVGFVLYLALRHGRLISRAVSSDNPEMLLLVVLGLTVLVAGVAQQLQVSAAVGAFLVGIALSGEVAEGARKLLTPLRDLFAAVFFVFFGLSTNPADIPPVLLPAALLAVVTVLTKIFTGWYAARRAGIGSRGRWRAGGTLVARGEFSIVIAGLAVATEPRIGPLATAYVLILVIVGPLTARWTQPIAEKIQALRDGDKPDQGGAAVQEVSKSAPERRLGDHDELTPEPAGEARGD
>NC_021177.1|WP_015609709.1|3882709_3883180_+|cation:proton-antiporter-regulatory-subunit
MGTRRTSLPGVGAQYDFTTETGQHISVVVHHDGRRFIGFYEQDDPDSCRLSVPLTTAEATALAHLIDPAPIDAVRTEGIDLVTEHIPLGSRSPYGGRLLGETRARTRTGASIVAVLRTHSAHPSPEPNFRLAIGDTLVAVGTREGVDALSEIIAEG
>NC_021177.1|WP_015609708.1|3881882_3882440_+|hypothetical-protein
MRENWRIKVSVVAGVSALAFSALMAAPAVADEAADSLQEVQMPAGVKIVEGLAPVAGADAPSLEPEADAPFSAAAAAKAAPAANTCLGSTAAYGSKGCFQHNGDIVWAGDTQKDGMSAAVGVYTDYGRAAEVCINKLGVNTWATCNKDYRETGNVRLRVFRYDGDTGKFYQPETWSGWIPVDGKY
>NC_021177.1|WP_015609707.1|3881352_3881685_+|hypothetical-protein
MRFRTVAASAALVLCAAAGATACSSSSDGSESTRPAGPASSTEAVPIEGMAGKIETGKRQAGPPQMDGQSARDSSVCAASAEEIPAECALDLSFAESSVGEPAAEAPDAQ
>NC_021177.1|WP_015609706.1|3880592_3881138_+|flavoprotein
MSEQPAQQAAKPFLYVVVCAAGIARDVGRLIAAAQERGWEVGVVATPQGLGFIDAVAVEAQTGYPIRSAWRVPGEPRPLPDPDAIAVVPATFNTVNKWAAGISDTLALGILCESYGFGIPTAVLPYVNSAQAAHPAYAESLRRLREMGILVGSYEPHRPKAVGGAGQFRWEEALELLDPLR
>NC_021177.1|WP_015609705.1|3880143_3880596_+|NUDIX-domain-containing-protein
MNERVRAVLVTDDDTMLVIRRTKPGIPDYWVLPGGGVEPSDESRESALHREIHEEIAGKADIVRLLHTMESDDERQLFYLARIATWSFADRTGPEFSAEGRGAYALEEIPLTVEGLDGIDLKPEEIAHVLRDALGDGTLTLQSSSSGSPA
>NC_021177.1|WP_015609703.1|3878294_3879071_+|aldo/keto-reductase
MKPPAGTIEIAGKTVSRLGLGTLRLTGPGGWGDPEDRPRAVSLLRQAVHQHGITHIDTADAYGPHTVEHLIKEALHPYPDELLIATKVGVVRPAPDVWMPLGHPAYLRASVEASLRRLGVERLELCYLHRIDWEVPVEDQIGTLQALQEEGKIGHIGLSKISGEDFRRWHGEIDIAAVQNVLNIHDRYDPVQELCREHDVPYVPYRPLAAGSAAHDGDVYTPLSWLLGLGPHVAPIPGTGSPRHLSNIVRAVTLGGWE
>NC_021177.1|WP_015609715.1|3890075_3895085_+|AAA-family-ATPase
MDRDITATAAATAPQGPEGDVDAGAYEVLRRRLSAQAGELVRRAEALNVRRTEEFGSTELRLLATEQVRTEHASVPRDLVAVGGQLLFGFERGPGARGEAGVDDVLLVRDAEAEGAPDGTPTLIEDDGFRREFSSLHRYFRDARLLRLRRVNGKLLAVFRTGENAEDIRVLRWALGADGSAGAFLDSQGERDHVFPPSHDFEWTVAGREAHVPGRHPHIAIGKGGGLFVDTLGGTLTVKVTDDTESPDGIYEEPVEEPLQSLADADVEYAEVGPLVLLRVRPYKETAWRHLVFNSLLSTVQRLDSIGPACHRLPEDQGIIFPGGYYLTTGTAKTFDTAEELAEPVFEGAVRSPNGEDVLYVFRSRDGVRSLLLPYNLIRQEVATPLTGRGHALLDDGTLVLLRDNPDGPARVHPLQRWQTPYVSDTYAASRPAGTGPLARTGNADLVRGISDCLALAHGVRDMTPTTAVYGQLAADCARAQDRYHWLSDPELGALAEPLGELRATAQQVLAEFTAVQELTRRAADALEETSTRITALVRRVRGEVPGSAAAWVERLTELRQAHGHLATIGEMRYADGERIAELSARTEDDIASAAQRAVSFLAREDAFDGYHEDIAGLVADAGAPATVRDASAVTDRLAVMTDGLATVTDVVAGLEIGDATVRTSILERIAEVLGGANRARATLEARRRELLSKEGRAEFAAEFALLGQAVTGALAAAESPEACDDQLARLMLQLENLESRFAEFDDFLAELAGRRSEVYEAFSARKQTLQDERARRAERLAGSAQRVLETIGRRLAALDDLDAVHTYFASDPMVAKVRRTADELRELGDPVRAEELDGRLKAARQEAGRALRDRSELYADGGSVIKLGRHRFAVNTQPFDLTLVPAGERLAFALTGTDYRAPVTDPAFEATRPYWEQLLPSESAAVYRGEHLAARLLAEQGAERLAALADDELALLVRESAAEAYDEGYTRGVHDEDATAILRALLRMYAEAGLLRHEPAARAAAQLFWAYGTDEALRTSWTRRAVSLARARDTFGLAPAIAVLQEEWAAAIGGSGSGAPADAVAAYLFEELTTGPAGFVVGASIRAFLDAFHRAAGPDAYADDLAALGGDLAARKQLVEGWLTPYAEATGAGTDPGDLAEAVAVELCPELERYGCEAPLTERVEGLLGDHPRIGSGGTLTVRIDELLARTGEFRTHAVPAFRAYQRLRTSLVAAERGRLRLDDHRPRVMSAFVRNRLLDEVYLPLIGDSLAKQLGTADADRRTDSQGLLLLVSPPGYGKTTLMEYVADRLGMVLVKISGPNLGHDVTSLDPAQAPSATARQEIEKINFALEAGNNTLLYLDDIQHTSPELLQKFIPLCDATRRIEGVRDGEPRSYDLRGKRFAVCMAGNPYTESGEQFRIPDMLANRADVWNLGEVLSGRDDVFALSFVENALTANPVLAPLAARSRDDLALLVRLAGGSDPTAHAEHLEHPYSAVELDAVLAVLRHLLTARDTVLAVNAAYIASAAQTDATRTEPPFRLQGSYRNMNKIAERIVPVMNDAELSAVVDDHYAGEAQTLTTGAEANLLKLAALRGKLTAGQAERWAAITASYVRTQALGGPDGDPMTRAVAALGLLADRIAAVETAIQRAADPRHLLAGPAGAANQPPGDQNRPGFPNHRAKITNIPH
>NC_021177.1|WP_015609716.1|3895115_3897122_+|TrkA-N-domain-protein
MLGFVPPLPQQPGRPQPGRPPATGHMIVCGDDALARRLAVELRFVYGERVTLLLPPGRDANSPETPLTQRGRAAALFGRMSAAMNRTAAAGNGGNDTNAGVEAVRIMEAPEPSDDVLEEAGVDRAAALALVYDDDERNIRAALTARRLNPRLRLVIRLYNRKLGQHLEELLDQAAAVAMPGIDPALLDASTTVLSDADTAAPALAATALTGSSKIIQAEGLLLRAAERPPPRPGETLDPGLCTLALLSSTTNDPAGAEGSDSSGDEGPELLPSEETVAAAEGRGTVVLEAISRAAPDRPATRMGGRGAPLSQVFSRRLRWSALGVAVAALSLVVASLLTTKDTAVHSTYLTLLDLLGMNDPAEDAPAARQIIQLLSGIAGLLLLPLLIAAVLEAFGTLRTASSLRRPPRGLSGHVVLLGLGKIGTRVLVRLRELDIPVVVVEEDPDARGIPLARSMHVPTVLGDVTQEGVLEAAKIRRAHALLALTSIDTTNLEATLYARSVKPDLRVALRLYDDEFATAVYRTLRTAHPQALTRSRSVSHLAAPSFAVAMMGRQILGAVPVERKVMLFAALEVAGHPQLEGRTVQQAFQASSWRVLAIDATPPADRNPDLAALPPYPPDGGAQPPSGLVWDLHPGYVLRAQDRVVIAATRRGLAELLRRQRSVLPRQ
>NC_021177.1|WP_015609717.1|3897138_3898239_-|tryptophan--tRNA-ligase
MTAAISTTAATVTTAATATTTAPTPAELRSAELERHLVQDPGRFRVLTGDRPTGPLHLGHYFGTLNNRVRLQNLGVDVFVLIADYQVLTDRDTAERLGEYTDGLLLDYLALGIDPARSTVFNHSAVPALNQLLLPFLSLVSVAELGRNPTVKDEIAHSRQSAVSGLMYTYPVHQAADILFCKGNVVPVGQDQLPHLELTRTVARRFNERYGNVFPEPDALLSAAPLLLGTDGTKMSKSRANSVPLGATADETARLIKGATTDADRHITYDPDARPGVSSLVLLAALCLERDPHEVAAEIGAGGAAALKRTVTDAVNSHLAPVRARRAEYAADLTYVRSVLRAGNERANAVAEATLEEVREAMGTIR
>NC_021177.1|WP_164711287.1|3898511_3898652_-|hypothetical-protein
MSGSDSDSESWKARGVALRVFVYIFATHLFAGFIWILFYVGDHAHK
>NC_021177.1|WP_015609720.1|3899429_3900542_+|LLM-class-flavin-dependent-oxidoreductase
MQFGIFTVGDVTTDPTTGRTPTENERIKATLAIAQKAEEVGLDVFATGEHHNPPFVPSSPTTTLGYIAARTENLILSTSTTLITTNDPVKIAEDYATLQHLADGRVDLMMGRGNTGPVYPWFGKDIRQGIPMAIENYALLHKLWREDVVDWEGKFRTPLQSFTATPRPLDGVPPFVWHGSIRSPEIAEQAAYYGDGFFHNNIFWPMEHTKKMVSLYRRRYAHYGHGTAEQAIVGLGGQVFMRKNSQDAVREFRPYFDNAPVYGHGPSLEEFTRETPLTVGSPQEVIERTLTFRDAVGDYQRQLFLMDHAGLPLKTVLEQLDILGEEVVPVLRKEFANLRPAGVPESAPVHPAVAAARTARTALTTDKKEV
>NC_021177.1|WP_015609721.1|3900547_3901207_+|FMN-reductase
MFATTPLRIVAVSAGLSQPSSTRLLADRLAAATRERLAAEQDRNVEVQVVELRDLAVDIAHHLLSGFPSATLREAIDAVTEADGLIAVTPVFTASYSGLFKSFFDLIDNTALTGKPVVIAATGGTARHSLVLEHALRPLFAYLRAVTVPTSVYAASEDWGSSGDEYTEGLPSRIRRAGGELASAVLGRTVSGASRAPGLDDGEDAVVPFEQQLADLRLD
>NC_021177.1|WP_015609722.1|3901349_3901772_+|universal-stress-protein
MGRIVVGVDGSDPSIKALHWAVRQAELTGDSVEAVNSWEYPATSWASMMPGLPEDFDPQALATVSLNEALEEALGAAGAAAISKIVVIGNPAQALLDRAKGASLLVVGARGRSGLKATLLGSVSLHVTQHAPCPVTVVRD
>NC_021177.1|WP_043972576.1|3901866_3905235_+|AAA-family-ATPase
MTPALFGRDHPAGVLRSEIARATDSHGGLVLVTGEAGIGKTTLVTDAAHEARRRGALVVGGSCWDSDSTPGYWPWVQVLRGLRRSATAAEWAAAQEAADGRLGILLGDPANDGKAAGPSTGEADGDNASGASADGAEAFGLYDAVTTALVTVSQSRPLVVVLDDLHSADPASLRLLEFAAQHAWFERLLLIGTYRDVEVEAPGHPLQQLILPLVSRASATLTLTGLGRDEVGALMAVTTGREPAPQLVDEVHRRTGGNPFFVEQTARLWHSGSPVSTIPPGVREAVRQRLSLLPDAVVSLLTAAAVLGREFRRQVLAVVHGSPVPQVERLLESAIVARVVVPRPSGSYAFAHDLLRETLYASLGDADTRRRHAAAVRALDAHGGLGDAVRPGDLARHAHLAGEELERDRRIDLLLAAARDASGRLADEEAIGHYRRALALASGEAGSEVAGMPDGTGEVAAGMPGGPDGASPGRVAVPDHRRAALICLDLGEQLRHSGETAEGDRLLDRAVDLARELDDPELLARVAITLYRRGTLGGGGAFMVTFLGEAHRKVTGKDGQDSLSADRLAQELAIHIMALARSGSDDEALAFSLWARHDSVWGLGSAVERLGLTDEMAVVGRRTQNLDMELHATSMRWVALLELGDPAFIDQYRTFIRAAERSELPRFALAVAVDGSLIASLQGRFTEAADALNGEALGMEGEDHEAFGFMGCHLHWSLHLLRGHFAEAEKVLAALPGARYPYPGLLEALTAVEQGDAAPALRLIAEQSDRPAPYPRAFMPLWLRLLAQTAATTGDRRLITLAEDELTPYTGQWVVSLYGCDIGGPVDLWLGMLAAARDDRDTAVATLTEAAASADRLRARPWAVRARLHLARSLLARAEPGDTGRARGLLAEVEREAAELGLHHLASAATALRTPPSASDHGTAIGSPAPAPVPVTAPTPAAAEFRRDGAVWQLRWDGRTVHVPDTKGLRDLHTLLGLPGADVPAVQLLAPEGGSVVIAAGQLGGDPVLDEEAKRRYKDHLDRLDAEIDRAAARGDTQQVEAYDRERQALLDQLRTAAGLGGRSRRLDDRTERARKTVTARIRDTLRKLDSLHPELAAHLRESVTTGTTCAYRPGHAPDWQL
>NC_021177.1|WP_015609724.1|3905314_3906172_-|ABC-transporter-permease
MSTATTKTELEGVELAAPDAERLSALLVGLDRPPRPSALSASLTFGWRAMLKIKHVPEQLFDVTAFPIMLVLMYTYLFGGALAGSTQEYIQFLLPGILVMSVVMITMYTGVSVNTDITKGVFDRFRTLPIWRPAPMVGYLLGDVLRYVLASAVMLTVGMIIGFRPDGGVLGVLAGVALLLVFAFAFSWIWTMFGLLLRTEKSVMGVSMMVIFPLTFLSNVFVDPKTMPGWLQAFVNNSPITHLATAVRELMAGNWPASALAWSLGWAGLIMVVFGAVTMRLYNRK
>NC_021177.1|WP_015609725.1|3906168_3907140_-|ATP-binding-cassette-domain-containing-protein
MSTELAIETTGLVKVFGENRAVDGVDLAVPTGTVYGVLGPNGAGKTTTVRMLATLLRPDAGSARVFGKDVVKEADAVRSRVSLTGQYASVDEDLTGSENLILLARLLGHSKPAARDRAAQLLEGFGLTEAAGKQVKNYSGGMRRRIDIAASILNTPDLLFLDEPTTGLDPRSRNQVWDIVRAVVGHGTTVLLTTQYLDEADQLASRIAVIDHGRVIAEGTKGELKASVGSGTVHLRLRDAAQRPEAERVLSLALDATVQLDADPVALTARIDAHGSDRGAAEQAARALAELARSGITVDNFSLGQPSLDEVFLALTDKKGVAA

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Crispr_ID: NC_021177_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_10

4056157-4056266

Orphan

Consensus_repeat	Method
GGTGGAGCGAACGCCGGAGCCGACGGCGGTGCGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_10

>merge|NC_021177|10|4056157-4056266|CRISPRCasFinder
GGTGGAGCGAACGCCGGAGCCGACGGCGGTGCGAACGCGGGAGCGGACGGTGGGGCCAATACAGGCACCACCGAAGGTGGTGCGAACGCCGGAGCCGACGGCGGTGCGAA

>NC_021177|10|10|4056157-4056266|CRISPRCasFinder
GGTGGAGCGAACGCCGGAGCCGACGGCGGTGCGAA	CGCGGGAGCGGACGGTGGGGCCAATACAGGCACCACCGAA
GGTGGTGCGAACGCCGGAGCCGACGGCGGTGCGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015609864.1\|4061153_4061444_+\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NC_021177.1\|WP_015609865.1\|4061518_4062154_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|236092
NC_021177.1\|WP_015609855.1\|4048482_4049925_+\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|131739
NC_021177.1\|WP_015609858.1\|4052562_4053246_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_021177.1\|WP_015609850.1\|4040116_4041100_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274904
NC_021177.1\|WP_015609852.1\|4041914_4043660_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270875
NC_021177.1\|WP_015609851.1\|4041096_4041813_-\|RNA-polymerase-sigma-factor-SigM	unknown	unknown	gnl\|CDD\|236604
NC_021177.1\|WP_015609863.1\|4060475_4060817_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015609866.1\|4062453_4062900_+\|50S-ribosomal-protein-L9	unknown	unknown	gnl\|CDD\|234659
NC_021177.1\|WP_015609868.1\|4064917_4066396_+\|replicative-DNA-helicase	unknown	unknown	gnl\|CDD\|273206
NC_021177.1\|WP_015609861.1\|4058084_4059116_-\|alanine-racemase	unknown	unknown	gnl\|CDD\|376473
NC_021177.1\|WP_003967857.1\|4062198_4062435_+\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NC_021177.1\|WP_015609849.1\|4039030_4040002_-\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_021177.1\|WP_015609862.1\|4059194_4060313_-\|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	unknown	unknown	gnl\|CDD\|225224
NC_021177.1\|WP_015609867.1\|4063121_4064459_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240541
NC_021177.1\|WP_099128488.1\|4056557_4058069_+\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|227937
NC_021177.1\|WP_015609856.1\|4050026_4051295_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_021177.1\|WP_015609853.1\|4043789_4045955_-\|murein-biosynthesis-integral-membrane-protein-MurJ	unknown	unknown	gnl\|CDD\|273763
NC_021177.1\|WP_015609854.1\|4046005_4048300_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015609857.1\|4051420_4052503_-\|inositol-3-phosphate-synthase	unknown	unknown	gnl\|CDD\|132491

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015609864.1\|4061153_4061444_+\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	3.17083e-40
NC_021177.1\|WP_015609865.1\|4061518_4062154_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	4.87193e-86
NC_021177.1\|WP_015609855.1\|4048482_4049925_+\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0
NC_021177.1\|WP_015609858.1\|4052562_4053246_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	3.99636e-17
NC_021177.1\|WP_015609850.1\|4040116_4041100_-\|hypothetical-protein	gnl\|CDD\|274904	TIGR03988, antisig_RsrA, mycothiol system anti-sigma-R factor. Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors].	0.000242918
NC_021177.1\|WP_015609852.1\|4041914_4043660_-\|serine/threonine-protein-kinase	gnl\|CDD\|270875	cd13973, PK_MviN-like, Pseudokinase domain of the peptidoglycan biosynthetic protein MviN. The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This family is composed of the mycobacterial protein MviN and similar proteins. MviN is an integral membrane protein that is essential for growth and is required for cell wall integrity and peptidogylcan (PG) biosynthesis. It comprises of 14 predicted transmembrane (TM) helices at the N-terminus, followed by an intracellular pseudokinase domain linked through a single TM helix to a carbohydrate binding extracellular domain. Phosphorylation of the MviN pseudokinase domain by the PG-sensitive serine/threonine protein kinase PknB recruits a forkhead associated (FHA) domain protein FhaA, which modulates local PG synthesis at cell poles and the septum. The MviN pseudokinase forms a canonical receptor kinase dimer.	2.36917e-55
NC_021177.1\|WP_015609851.1\|4041096_4041813_-\|RNA-polymerase-sigma-factor-SigM	gnl\|CDD\|236604	PRK09643, PRK09643, RNA polymerase sigma factor SigM; Reviewed.	7.86932e-92
NC_021177.1\|WP_015609862.1\|4059194_4060313_-\|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	4.29434e-33
NC_021177.1\|WP_015609866.1\|4062453_4062900_+\|50S-ribosomal-protein-L9	gnl\|CDD\|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	3.64128e-64
NC_021177.1\|WP_015609868.1\|4064917_4066396_+\|replicative-DNA-helicase	gnl\|CDD\|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_021177.1\|WP_015609861.1\|4058084_4059116_-\|alanine-racemase	gnl\|CDD\|376473	pfam01168, Ala_racemase_N, Alanine racemase, N-terminal domain.	5.04558e-07
NC_021177.1\|WP_003967857.1\|4062198_4062435_+\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	2.92458e-37
NC_021177.1\|WP_015609849.1\|4039030_4040002_-\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	5.22983e-156
NC_021177.1\|WP_099128488.1\|4056557_4058069_+\|DUF2029-domain-containing-protein	gnl\|CDD\|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	6.07039e-42
NC_021177.1\|WP_015609867.1\|4063121_4064459_-\|MATE-family-efflux-transporter	gnl\|CDD\|240541	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	6.39978e-120
NC_021177.1\|WP_015609853.1\|4043789_4045955_-\|murein-biosynthesis-integral-membrane-protein-MurJ	gnl\|CDD\|273763	TIGR01695, Putative_lipid_II_flippase_MurJ, murein biosynthesis integral membrane protein MurJ. This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	2.42262e-148
NC_021177.1\|WP_015609856.1\|4050026_4051295_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.63524e-42
NC_021177.1\|WP_015609857.1\|4051420_4052503_-\|inositol-3-phosphate-synthase	gnl\|CDD\|132491	TIGR03450, mycothiol_INO1, inositol 1-phosphate synthase, Actinobacterial type. This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.	0

>NC_021177.1|WP_015609858.1|4052562_4053246_-|PadR-family-transcriptional-regulator
MSRRSGILEFAVLGLLRESPMHGYELRKRLNTSLGIFRAFSYGTLYPCLKTLVTSGWLIEEPVGDPADTTPASSLTGRRAKIVYRLTAEGKEHFEELLSHTGPDAWEDEHFAARFAFFGQTEREVRMRVLEGRRSRLEERLEKMRASLARTRERLDDYTLELQRHGMESVEREVRWLNELIESERSGRDQRRSSPEGSAQQDTSGETGGLPRHRGNTPPDPSDDTAK
>NC_021177.1|WP_015609857.1|4051420_4052503_-|inositol-3-phosphate-synthase
MGSVRVAIVGVGNCAASLVQGVEYYKDADPAGKVPGLMHVQFGEYHVSDVEFVAAFDVDAKKVGLDLADAIGASENNTIKIADVPNTGVTVQRGHTHDGLGKYYRETIEESADAPVDIVQVLKDKQVDVLVCYLPVGSEVAAKFYAQCAIDAKVAFVNALPVFIAGTKEWADKFTEAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVVLDRTMQLNVGGNMDFKNMLERERLESKKISKTQAVTSQIRDRELGADNVHIGPSDYVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPILSASSYFMKSPPVQYFDDEARENVERFINGDTES
>NC_021177.1|WP_015609856.1|4050026_4051295_-|MFS-transporter
MSVARDLRTLLRLRNFRRLLTVRLLSQSADGVYQVALAAYVVFSPEKQTSAAAIASAMAVLLLPYSLVGPFAGVLLDRWPRRQVFLYGNLLRAALACCTALLILASVPDWLFYASALCVTAVNRFVLAGLSAALPRVVDTEQLVVANSLSPTAGTLAATAGGGIAFVVRLVADESDAAVVLLGAMLYLLSALASLSLPRALLGPDPDGTPLRLRAALTVTAHGLVAGVRHLRERTHAARALAAMTVLRFCYGALTVMVLMLCRYAWADEESDGLALLGLAVGASGAGFFVAAVVTPWAVGRFGRYGWIVVCAGSAAVLVPALGLSFAPVPMLIAAFVLGVVTQGAKIATDTVVQTSVDDSFRGRVFSLYDVLFNVAFVSAAGVAAVMLPPDGRSVAVVAGVAALYAAVAVAMFRRRYTSSAG
>NC_021177.1|WP_015609855.1|4048482_4049925_+|CCA-tRNA-nucleotidyltransferase
MPNANEENASALNQVQHRAVSELLRVSPVADDLARRFQEAGFGLALVGGSVRDALLGRLGNDLDFTTDARPEDVLTIVRPWADAVWEVGIAFGTVGSQKDGYQIEVTTYRSEAYDRTSRKPEVSYGDSIEEDLVRRDFTVNAMAVALPEKEFIDPHGGLKDLAERVLRTPGTPEASFSDDPLRMLRAARFAAQLDFEVAPDVVTAMTEMAGRIEIVSAERVREELNKLILSSHPRKGLGLLVDTGLADHVLPELPALRLESDEHHRHKDVYEHSLTVLEQAIDLEEDGPDLVLRLAALLHDIGKPRTRRFEKDGRVSFHHHEVVGAKMTKKRMTELKYSNDLVKDVSRLVELHLRFHGYGDGEWTDSAVRRYVRDAGPLLERLHKLTRSDCTTRNKRKANALSRTYDGLEERIAMLQEQEELDSIRPDLDGNEIMQALGVGPGPVIGKAYAFLLELRLEHGPMGHDAAVAALKEWWAEQG
>NC_021177.1|WP_015609854.1|4046005_4048300_-|hypothetical-protein
MAQAADIQGMRPSPARRWLRRTASVALGAPLLAGLLAVPTAGSAGASAPDKAPTGSSTVDVALDTLSPAAPVKGDTLTVSGTLTNKGRQTIDGAEIDLRVGPRLSGRGEVDDAAKRKGYTPGADPDAIDDKYTVKIAKLPKGISQNFTLAVPVDKLDLDASGVYQLGVSVSGRTAAAPFEQVLGIERSFLPWQPEESDKRTKLTFLWPLIASPHVTAETRSDEQQTPVFTDDALAEELAPGGRLQQMVALGSRLPVTWVIDPDLLASVAAMAGGYEVKSGDTTVPGKNRAVAGQWITALQKVVEDGKVIALPFGDPDLASIAHRGKGVSGTLSHLQNASTVGASTVETILHVKPSTDFAWPVKGAVDPGIVDVATSAGAHHVIARSDSFKETGSLPYTPTAARPIGGGTTAVVADHRLSTAFDGSLLRADASTLAVQKFLAQTLTLNEQAPDNERSIVVAPQRMPTTAQAQTMARALEALSGNRWTQPQDLVAASEVKPDPLATTKVPRASAYPKKLRNQELPTQAFQDIRTTQGSIDSFETILTQPERVVTPFGNAVNRSMSTSWRGRSLEAQAYRDAVLTYLKDLTGEVQLIDKSDVTLSGRSATIPVTVQNKLVQGVDRLVLRLKSDNIRLKFNDDGTMAELPVRIGGGHSQSVKFDTATSANGRAQVTARLFTEDGTPYGEEMTFTVKVSEVTPTVLLVIAGGLLLLVLAGVRMYSHRKRAVASDTANGGGGEPEQPSDPTPDTGPESGAPSGTGEKVDR
>NC_021177.1|WP_015609853.1|4043789_4045955_-|murein-biosynthesis-integral-membrane-protein-MurJ
MNAPYDGDRGQGAGGAGSPSGPPVPPGADQDGRQVPPDPYLQHAYEDDPYRAQDLAAQDPVGEALYDRASHPPPPPGTYQEPQALYQQPPAAPYAPDPRIWAQTPPPEPSGPSRHLPYGDRPATTQFVGVDDLVTQASDDRQEPDAFAHLFRDQEGSGKPPAPPEPEPAPAPIPPKSGGGKFSGVLKSSALMAAGTLVSRLTGFIRSLVITAALGAALLGDSFTIAYTLPTMIYILTVGGGLNSVFVPQLVRAMKDDEDGGEAFANRLLTLVMVALGLIVAVAVLVAPVLIQLMSNTIADDVAANSVAVTFARYCLPTIFFMGVHVVMGQILNARGKFGAMMWTPVLNNIVMIITFGLFIWVYGTSAESRMGVDTIPPEGIRLLGIGTLLGLVVQALAMIPYLREAGFRFRPRFDWKGHGLGKTVKLAKWTVLFVLANQAGVLVVTQLATSAGKLAGRDGTGFLAYSNAQLIWGMPQAIITVSVMAALLPRISRAAHDNDPGAVRDDISQGLRNSAVAIVPVAFTFLALGLPMCTLLYASSGAEAARSMGFILMAFALGLIPYSVQYVVLRGFYAYEDTRTPFYNTVIVAAVNAAASALCYVVLPARWAVVGMAFSYGLAYAVGVGVAWRRLRNRLGGDLDGAHIVRTYARLCMAAVPAAIIGGGVGFAILELLGTGALGSLAALICGGILLLGIFFVAAKKMRIEEVNGLVGMVRGRLGR
>NC_021177.1|WP_015609852.1|4041914_4043660_-|serine/threonine-protein-kinase
MAERSTAAVDVADNGGNEPLAAKADEATNDGTAQAEDTEGASPEKPENPKGQDGGRARSEAVPATPDVHSGHKLAGRYRLEECVTRLDGFSSWRAVDEKLRRAVGVHLLPANHPRARSVLAAARSSALLGDPRFVQVLDAVEEDDLVYVVHEWLPDATELTALLAAGPMDAHDAYQLVSQLSHAMAAAHREGLTHLRLTPGAVLRSSTGQYRIRGLAVNAALRGIASERPLRQDTEAIGALLYAALTKRWPYESDAYGLSGLPKGMGLIAPDQVRAGVHRGLSELAMRALANDGATASRQEPPCTTPDELAKAVAAMPRVLPPEPTFAAQPVYQQPGYQRTTYQQGTYGRPSTHPSSVPQPVLAAPPAPLQSRTGRVLKWSVSALLIAALGLGSWQLAETLLDQRKGSDDTGVTETTDDEKEPAPAPPKPLTIAEATEFMPDGSGIQPGDVPNAIDDDSSTAWVTHRYRGFPNFGNLPQRRQGSGIIVDLGKVQDVRAIDVDMYRSGQTTAVFAAGPNASSPSSSADFPQRIVEKKVAGKTLKEELEKPVRTRYVLIHITELPADGTGGYRGGIADISVLG
>NC_021177.1|WP_015609851.1|4041096_4041813_-|RNA-polymerase-sigma-factor-SigM
MDSVPPEAPSDSDLLALHVAGAPDAFGELVRRHRDRLWAVALRTLGDREEAADAVQDALVSAFRAAHTFRGQSAVTTWLHRITVNACLDRVRKAASRKTSPVDDADRLDQLLEPHESAEAPAERQDLHRQLFAALATLPAEQRAALVLVDMQGYPVAEAASILDVPTGTVKSRCARGRARLAPLVRHLRAGDGNEGPDGESRTTGRNRTPGTSVPPASGPKDAGASDAAAAKGGGGRP
>NC_021177.1|WP_015609850.1|4040116_4041100_-|hypothetical-protein
MTSATDTAQHPEVSEISDLAEGLLTASRAAEVRRHLSECELCAEVRDSLEEIRGLLGTLPDPEPMPEDIAARIDAALAAEARSDAGAGEPADASEAAAVSRDADVSRETENVETSDASSVTPRTGSSPDRPAGRPQGATGPGRRNARRRRRVVILGTACGAALIGMSVLFLQNLSSSQNASDASADRAVSASESGAHSYSQDTLEAEVQGLLAGGASTEKYDGQKQSPSTDERAVPEAETPDTTTSRNPLSAPAVDVPPCVQQATGRTTPALALDEGTYQGTDAFLVVLPHPSDPTRVQAYVVAASCVDTAPGSTGRLLLTEAYDRP
>NC_021177.1|WP_015609849.1|4039030_4040002_-|thioredoxin-disulfide-reductase
MSDVRNVIIIGSGPAGYTAALYTARASLSPLVFEGAVTAGGALMNTTDVENFPGFQDGIMGPELMDNMRAQAERFGAELIPDDVVAVDLTGDIKTVTDTAGTVHRAKAVIVTTGSQHRKLGLPNEDALSGRGVSWCATCDGFFFKDHDIAVIGGGDTAMEEATFLSRFAKSVTIVHRRDTLRASKAMQDRAFADPKIKFAWDSEVAEVKGEQKLSGLTLRNTKTGETSELPVTGLFIAVGHDPRTELFKGQLELDDEGYLKVEAPSTRTNLTGVFGAGDVVDHTYRQAITAAGTGCSAALDAERFLAALADVEPAEPEKTPAV
>NC_021177.1|WP_099128488.1|4056557_4058069_+|DUF2029-domain-containing-protein
MCGMPSPSAEDTSVQQQERPVVRPTDQDEVAAAGSELFGGRVGRWARLGDGPLTPVRVVALVAIGMFALGMVQKIPCYEWAWFRGATSQYTHACYSDIPHLFLGRGFADGLVPYFDRLSGDMQYLEYPVLTGVFMQVAAWLTLTPDSDPIQQREQMYWMVNAGMLMICAVVIAVCTVRTHRRRPWDGLLVALAPAFALTATINWDLLAVALTAAAMLMWSRGRVLAFGILIGLATAAKLYPVLLLGPLLVLCWRAGRWREFSTALLGAGAAWLVVNLPVMLYAPEGWRKFYTFSQERPIDFGSFWLIITQRTGKPIDVETVNTASVVLMVVFCAGIAGLALTAARRPRFAQLAFLVVAAFILTNKVYSPQYVLWLIPLAVLARPRWRDFLIWQACEVMYFLGIWFYLAYTSGGDKHQGLPQEGYQLAIALHLLGTLYLCALVVRDILLPEKDPVRRDGSDDPSGGVLDGAPDAFVLAPEARPPGHTAPAVTGPQVEWGAARER
>NC_021177.1|WP_015609861.1|4058084_4059116_-|alanine-racemase
MALSLYVDTARWRAHQKSVIDQFPGLVPVCKGNGYGFGHERLADETIRFGSDTLAVGTTYEAATIKDWFSGDLLVLTPFRRGEEPVPLPDRVIRSVSSVDGVHALVGARVVIECMSSMKRHGVKEEELGLLHAAIEDVRLEGFALHLPLDRTDGSDAVEEVIGWMDRLRAARLPLHTMFVSHLRAEELARLQQQFPQTRFRARIGTRLWLGDHEATEYRGAVLDVTPVVKGDRFGYRQQKAASDGWLVVVAGGTSHGVGLEAPKALHGVMPRAKGVARAGLATVNRNLSPFVWAGKQRWFAEPPHMQVSILFVPSDAQEPRVGDELVAHLRHTTTQYDRLVDH
>NC_021177.1|WP_015609862.1|4059194_4060313_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein
MSLTLRTISREQHLAYIQNLPSASHCQVPAWADVKTEWRSENLGWFDKNGEMVGAGLVLYRQLPKIKRYLAYLPEGPVINWYAPNLDDWLQPMLAHLKQQGAFSVKMGPPVVIRRWDSTAIKSGIQDPDVKRLRDVEATHIEPRAFEVADRLRKMGWQQGEDGGAGFGDVQPRYVFQVPLANRSLEDVLKGFNQLWRRNIKKADKAGVEVVQGGYEDLAEWQRLYEITAVRDHFRPRPLSYFQRMWTVLNSEDPNRMRLYFARHNGVNLSAATMLVVGGHVWYSYGASDNIGREVRPSNAMQWRMLRDSYAMGATVYDLRGISDSLDENDHLFGLIQFKVGTGGEAVEYVGEWDFPLNKLLHKALDIYMSRR
>NC_021177.1|WP_015609863.1|4060475_4060817_-|hypothetical-protein
MAQTIRPAGSRSATGRPATGSLFATDGRPHPVQDVLMVVTGVLGVLAFVTAMFHHLHLISSWAGLVGILTGLYGQYISKTTWERFGLIMGIGASAVGFYLGMAHGGLFGGVIT
>NC_021177.1|WP_015609864.1|4061153_4061444_+|30S-ribosomal-protein-S6
MRHYEVMVILDPDLEERAVSPLIENFLSVVREGNGKVEKVDTWGRRRLAYEIKKKPEGIYSVIDLQAEPAVVKELDRQMNLNESVLRTKVLRPEIH
>NC_021177.1|WP_015609865.1|4061518_4062154_+|single-stranded-DNA-binding-protein
MAGETVITVVGNLVDDPELRFTPSGAAVAKFRVASTPRIFDRQTNEWKDGEGLFLTCSVWRQAAENVAESLQRGMRVVVQGRLKQRSYEDREGVKRTVYELDVEEVGPSLKNATAKVTKTTGRGGQGGQGGYGGGGQQGGGNWGGGPGGGGQQGGGGAPADDPWATGAPAGGPQSGGQQGGGSGWGGSPGGSGGSGGSGGSGGGYSDEPPF
>NC_021177.1|WP_003967857.1|4062198_4062435_+|30S-ribosomal-protein-S18
MAKPPVRKPKKKVCAFCKDKTQYVDYKDTNMLRKFISDRGKIRARRVTGNCTQHQRDVATAVKNSREMALLPYTSTAR
>NC_021177.1|WP_015609866.1|4062453_4062900_+|50S-ribosomal-protein-L9
MKIILTHEVSGLGTAGDVVDVKDGYARNYLVPRGFAIRWTKGGEKDVAQIRRARKIHEIATIEQANEIKAKLESVKVRLAVRSGDAGRLFGSVTPADVASAIKAAGGPDVDKRRVELGSPIKTLGGHQVSVRLHPEVAAKLGVEVVAA
>NC_021177.1|WP_015609867.1|4063121_4064459_-|MATE-family-efflux-transporter
MTPAPTTPRTGRRRHDREIVALAVPAFGALVAEPLFVMVDSAIVGHLGTPQLAGLGIAAALLMTAVSIFVFLAYATTAAVARRVGAGDLPAAIRQGMDGIWLALLLGAVVVALAIPSAPWLVDVFGASDTAAPYAITYLRISSFGIPAMLVVLAATGVLRGLQDTRTPLYVAIGGFTANGILNVVLVYGAGFGIAGSAWGTVMAQAGMAVAYLIVVVRGARKHGASLRPDAAGIRASARAGAPLLVRTLSLRAVLMIATAVAARLGDSDIAAHQIVLSLWSLTAFALDAIAIAGQAIIGRYLGAGDEKGAREACRRMVEWGIGCGVVLGVLIILARPLFIPLFTSDPAVKDTLLPALLVVALSQPIAGVVFVLDGVLMGAGDGRYLAWAMLVTLAVFAPVALLVPSLGGGLTALWWAMTLMMAVRLITLWVRARSGRWIVTGATR
>NC_021177.1|WP_015609868.1|4064917_4066396_+|replicative-DNA-helicase
MSIPEPLDDPWTEAGPGDRLPVSRPRRGERKGNREDRHDRGSDEGWDGGSPGFERVPPQDLDAEQSVLGGMLLSKDAIADVVEIIKGHDFYRPAHETVYTAILDLYAKGEPADPITVAAELVKRGEITKVGGAPYLHTLVQSVPTAANASYYAEIVHERAVLRRLVEAGTKITQMGYAADGDVDEIVNSAQAEIYAVTEQRTSEDYLPLGDIMEGALDEIEAIGSRSGEMTGVPTGFTDLDALTNGMHPGQMIVIAARPAMGKSTLALDFARAASIKNNLPSVIFSLEMGRNEIAMRLLSAEARVALHHMRSGTMTDEDWTRLARRMPEVSAAPLYIDDSPNLSMMEIRAKCRRLKQRNDIKLVIIDYLQLMQAGGSKRSESRQQEVSDMSRNLKLLAKELEVPVIALSQLNRGPEQRTDKKPMVSDLRESGSIEQDADMVILLHREDAYEKESPRAGEADIIVGKHRNGPTATITVAFQGHYSRFVDMAQT

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Crispr_ID: NC_021177_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_11

4471578-4471708

Orphan

Consensus_repeat	Method
CGGCGAGCAGGGTCCGCGTACGG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_021177_11

>merge|NC_021177|11|4471578-4471708|CRISPRCasFinder
GGGCGAGGAGTATCCGCGTATGGGAGACGGCGGCGGGGACACGCGTACGGGGAGCGGCGAGCAGGGTCCGCGTACGGGGAGCGGCGAGCAGGATCCGCGTAAGGGCGACGGCGAGCAGGATCCGCGTACGG

>NC_021177|11|11|4471578-4471708|CRISPRCasFinder
GGGCGAGGAGTATCCGCGTATGG	GAGACGGCGGCGGGGACACGCGTACGGGGAG
CGGCGAGCAGGGTCCGCGTACGG	GGAGCGGCGAGCAGGATCCGCGTAAGGGCGA
CGGCGAGCAGGATCCGCGTACGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_043972823.1\|4468767_4469274_+\|flavin-reductase	unknown	unknown	gnl\|CDD\|376575
NC_021177.1\|WP_031124558.1\|4474112_4475387_+\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	unknown	unknown	gnl\|CDD\|238430
NC_021177.1\|WP_015610245.1\|4464053_4465523_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_021177.1\|WP_043974672.1\|4477987_4478932_+\|cyclase	unknown	unknown	gnl\|CDD\|176870
NC_021177.1\|WP_015610244.1\|4463282_4463969_+\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|213983
NC_021177.1\|WP_015610241.1\|4460766_4461168_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|211538
NC_021177.1\|WP_015610249.1\|4469275_4471024_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NC_021177.1\|WP_164711260.1\|4468616_4468829_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_032759776.1\|4466949_4468620_+\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|380163
NC_021177.1\|WP_015610246.1\|4465697_4466642_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_021177.1\|WP_015610256.1\|4477142_4477928_+\|3-oxoacyl-ACP-reductase-FabG	unknown	unknown	gnl\|CDD\|187649
NC_021177.1\|WP_015610252.1\|4473765_4474095_+\|TcmI-family-type-II-polyketide-cyclase	unknown	unknown	gnl\|CDD\|377397
NC_021177.1\|WP_015610243.1\|4461804_4463172_+\|cation/H(+)-antiporter	unknown	unknown	gnl\|CDD\|215608
NC_021177.1\|WP_015610255.1\|4476686_4476959_+\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|376348
NC_021177.1\|WP_043974675.1\|4479071_4481438_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236199
NC_021177.1\|WP_015610260.1\|4483150_4484059_+\|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl\|CDD\|225002
NC_021177.1\|WP_015610259.1\|4481506_4483081_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_021177.1\|WP_015610251.1\|4472203_4473670_+\|Oxygenase-like-protein	unknown	unknown	gnl\|CDD\|236199
NC_021177.1\|WP_043972819.1\|4461189_4461771_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|377026
NC_021177.1\|WP_043974670.1\|4475449_4476646_+\|ketosynthase-chain-length-factor	unknown	unknown	gnl\|CDD\|238428

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_043972823.1\|4468767_4469274_+\|flavin-reductase	gnl\|CDD\|376575	pfam01613, Flavin_Reduct, Flavin reductase like domain. This is a flavin reductase family consisting of enzymes known to be flavin reductases as well as various oxidoreductase and monooxygenase components. VlmR is a flavin reductase that functions in a two-component enzyme system to provide isobutylamine N-hydroxylase with reduced flavin and may be involved in the synthesis of valanimycin. SnaC is a flavin reductase that provides reduced flavin for the oxidation of pristinamycin IIB to pristinamycin IIA as catalyzed by SnaA, SnaB heterodimer. This flavin reductase region characterized by enzymes of the family is present in the C-terminus of potential FMN proteins from Synechocystis sp. suggesting it is a flavin reductase domain.	3.51298e-41
NC_021177.1\|WP_031124558.1\|4474112_4475387_+\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	gnl\|CDD\|238430	cd00834, KAS_I_II, Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.	0
NC_021177.1\|WP_015610245.1\|4464053_4465523_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.28004e-65
NC_021177.1\|WP_043974672.1\|4477987_4478932_+\|cyclase	gnl\|CDD\|176870	cd08861, OtcD1_ARO-CYC_like, N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains. This family includes the N- and C- terminal aromatase/cyclase (ARO/CYC) domains of Streptomyces rimosus OtcD1 and related domains. It belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. ARO/CYC domains participate in the diversification of aromatic polyketides by promoting polyketide cyclization. They occur in two architectural forms, didomain and monodomain. Didomain aromatase/cyclases (ARO/CYCs), contain two ARO/CYC domains, and are associated with C7-C12 first ring cyclized polyketides. Streptomyces rimosus OtcD1 is a didomain ARO/CYC. The polyketide Oxytetracycline (OTC) is a broad spectrum antibiotic made by Streptomyces rimosus. The gene encoding OtcD1 is part of oxytetracycline (OTC) gene cluster. Disruption of this gene results in the production of novel polyketides having shorter chain lengths (by up to 10 carbons) than OTC. Monodomain ARO/CYCs have a single ARO/CYC domain, and are often associated with C9-C14 first ring cyclizations, these latter domains belong to a different subfamily in the SRPBCC superfamily.	1.56057e-50
NC_021177.1\|WP_015610244.1\|4463282_4463969_+\|hemerythrin-domain-containing-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	1.30734e-18
NC_021177.1\|WP_015610241.1\|4460766_4461168_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|211538	TIGR00026, Hypothetical_protein_Rv1261c/MT1299/Mb1292c., deazaflavin-dependent oxidoreductase, nitroreductase family. This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity].	2.40253e-09
NC_021177.1\|WP_015610249.1\|4469275_4471024_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NC_021177.1\|WP_032759776.1\|4466949_4468620_+\|NAD(P)-binding-protein	gnl\|CDD\|380163	NF033113, halo_ClmS, chloramphenicol-biosynthetic FADH2-dependent halogenase CmlS.	7.11037e-18
NC_021177.1\|WP_015610246.1\|4465697_4466642_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.80844e-14
NC_021177.1\|WP_015610256.1\|4477142_4477928_+\|3-oxoacyl-ACP-reductase-FabG	gnl\|CDD\|187649	cd08945, PKR_SDR_c, Polyketide ketoreductase, classical (c) SDR. Polyketide ketoreductase (KR) is a classical SDR with a characteristic NAD-binding pattern and active site tetrad. Aromatic polyketides include various aromatic compounds of pharmaceutical interest. Polyketide KR, part of the type II polyketide synthase (PKS) complex, is comprised of stand-alone domains that resemble the domains found in fatty acid synthase and multidomain type I PKS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.68026e-141
NC_021177.1\|WP_015610252.1\|4473765_4474095_+\|TcmI-family-type-II-polyketide-cyclase	gnl\|CDD\|377397	pfam04673, Cyclase_polyket, Polyketide synthesis cyclase. This family represents a number of cyclases involved in polyketide synthesis in a number of actinobacterial species.	2.43317e-57
NC_021177.1\|WP_015610243.1\|4461804_4463172_+\|cation/H(+)-antiporter	gnl\|CDD\|215608	PLN03159, PLN03159, cation/H(+) antiporter 15; Provisional.	4.50212e-62
NC_021177.1\|WP_015610255.1\|4476686_4476959_+\|acyl-carrier-protein	gnl\|CDD\|376348	pfam00550, PP-binding, Phosphopantetheine attachment site. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of the anguibactin system regulator AngR has the attachment serine replaced by an alanine.	9.14233e-07
NC_021177.1\|WP_043974675.1\|4479071_4481438_+\|SDR-family-oxidoreductase	gnl\|CDD\|236199	PRK08244, PRK08244, monooxygenase.	2.75276e-101
NC_021177.1\|WP_015610260.1\|4483150_4484059_+\|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl\|CDD\|225002	COG2091, Sfp, Phosphopantetheinyl transferase [Coenzyme metabolism].	7.78398e-27
NC_021177.1\|WP_015610259.1\|4481506_4483081_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.34396e-33
NC_021177.1\|WP_015610251.1\|4472203_4473670_+\|Oxygenase-like-protein	gnl\|CDD\|236199	PRK08244, PRK08244, monooxygenase.	2.73429e-149
NC_021177.1\|WP_043972819.1\|4461189_4461771_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|377026	pfam03358, FMN_red, NADPH-dependent FMN reductase.	9.1208e-30
NC_021177.1\|WP_043974670.1\|4475449_4476646_+\|ketosynthase-chain-length-factor	gnl\|CDD\|238428	cd00832, CLF, Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein (ACP). CLFs are similar to other elongation ketosynthase domains, but their active site cysteine is replaced by a conserved glutamine.	0

>NC_021177.1|WP_015610249.1|4469275_4471024_+|ATP-grasp-domain-containing-protein
MRKVLIANRGEIAVRVARACRDAGIASVAVYADPDRDALHVRAADEAFALGGDTPAASYLDMAKVLQAAEDSGADAIHPGYGFLSENAEFAQAVLDAGLTWIGPPPQAIRDLGDKVAARHIAQRAGAPLVAGTPDPVSGSDEVVAFAQQNGLPIAIKAAFGGGGRGLKVARTLEEIPELYDSAVREAVAAFGRGECFVERYLDKPRHVETQCLADTHGNVVVVSTRDCSLQRRHQKLVEEAPAPFLSPAQNEELYAASKAILKEAGYVGAGTVEFLVGADGTISFLEVNTRLQVEHPVTEEVTGIDLVREMFRIADGEELGYGDPAVRGHSFEFRINGEDPGRGFLPAPGTVTTFAPPAGPGVRLDAGVETGSVIGPAWDSLLAKLIVTGATREQALQRAARALAEFQVEGMATAIPFHRAVVTDPAFTADPFTIHTRWIETEFTNTIEPFGTPAEATDTESIRERIVVEVGGQRLEVVLPSFLALARTAPAPAGPVRSRPRGGGTRTAAASGDTLASPMQGTVVKVAVEEGQKVEEGELIVVLEAMKMEQPLTAHRSGTVSGLPATGATVSTGAAICDIKD
>NC_021177.1|WP_043972823.1|4468767_4469274_+|flavin-reductase
MTVITAGTEGEAEGTTVNSFTSVSLDPSLVLFCLHKESRMHAVIGRHGTFAVNFLAGGQQELARAFAARRPEGFHGVPHHFAPDGPPVLSEALAYLTCSTVAVHSGGDHDIVVGEVLELAAPGSEQEPLIFFDGTLGPLESTGGRFGQAVGAQDPAPKGPAASPARAG
>NC_021177.1|WP_164711260.1|4468616_4468829_-|hypothetical-protein
MKEFTVVPSASPSVPAVMTVTPVAKRPQIRRNSFGAIGCFTWLWVSERAADMGNPFPDRLLVSERAGNRA
>NC_021177.1|WP_032759776.1|4466949_4468620_+|NAD(P)-binding-protein
MPQEATYDVIILGSGIAGSVTGAILAKHGARVLLVDATTHPRFAVGESMTPQLVEWIHILAERHDLPELKSLASVKQSTLDIAPTFGTKAHFGFMKHEVGQEPDPREATQLALPKIFHQNSHMFRQDSDSFMFHVAVKYGCVAKQSWRANEVDIDEDGVTVTGRSGAPGAEPESFRAQYVVDASGFRSPLAQKFDLRDQPARFKHHSRSMFTHYVGVKRFDDVSGHPKELRPPADWHTGTMHHLIERGWFWIIPFDNHKDSRNPLCSVGLTMDERTYPKPKDITPEQEFELFLDKYPAVKRQFVGASKVREWVSTDRLQYSSKQTIGDRWCLMSHAAGFLDPLFSRGLSNTLEVVDALTSRLLEAFKDGDYSAERFEYVERLEQGLLQYNDEIVNSSFIAFSHFRLWNAVFRVWGSFITPGTMRLTRARLKHFKDKDQRHFRELEQNDYPGLWWPQSDKFKILLETTAEACEKYEAGALTGDEAADIIFKLIDESPIVNPVFGWKDENKRFIYPSVATMARFLYWASVQAPPEMNSVGREFLLGIVKAGSKVRKLL
>NC_021177.1|WP_015610246.1|4465697_4466642_+|MarR-family-transcriptional-regulator
MTIVRGEPDATRGPISETEATAEVPGVLPEGLTGFIGYLLRRVFAQFTTFADGPEDGSRDFLVLDALTGGDWVSQLDLAERLGINRTIMVGVIDRLEGRGQVLRTRNPDNRRQYILSLTDEGRSAVEAGRRAVAERDARLTAALTPEQVTRLNTLLARLLPQGTQDLVQGTEHLVEQAHHRLRRLGDEKLAGTGLRVRHYGPLSILATHGPCPQQRLAQELAITGPATSQLVDELVDGGMVHRGRDPHDRRRHALELTELGHTQLKAVAEAVDLLAADTAVLLGPGGEDELRALLVQLLEPAHPGVAEAAGRRG
>NC_021177.1|WP_015610245.1|4464053_4465523_+|MFS-transporter
MSMQDRTEAAPPGAGTPPGSAAPAPSGDKLGLALAVIAAAQLMLVLDNTIVAVALPSMQSALGLSDANLGWVITAYALAFGGLLLAGGRAGDLFGRRRVFRTGLVVFTLASLLGGLAGSGEVLLIARVLQGVGAAIAAPTALSLLASTFPAGPARNKALGVYGAMGGLGSVVGLLLGGALTEFLSWRWVMYINIPIAVAVLIGTSVLKEGERDRGKVDVPGALTATFGFGSLVYGINRAGEKGLGDSTTLIALAVAIVLIVAFIAIQRSSRAPMVPGAVLADKSRAGANAVMFLVGAGMFATFYFLTLYMQIVKGYEPMITGLAYLPFAIGIGIAAGGVGPQLLAKVPERSVIAVGLVIGIAGMVWLSLLEPGQNAFAVLLPAQLVCGFGLGLVFVTVTIISVRGVSPEDTGIAAGLINTSQQIGGAVGLAILAATASVITEGRLPGDRSEALTTGYSYGLLIGGGIYLVALIVTLGTIKATAPQSQPH
>NC_021177.1|WP_015610244.1|4463282_4463969_+|hemerythrin-domain-containing-protein
MGDFKNLDMTMMFAIHDALRRELERIARITSRVDEDPRHVLSTAVGWELFKKFLTAHHTSEDLTVWPAMYKALDGRDAQAEIALLDAMEAEHAVIDPLLTDIDAALADRDTGAERLGGLVDTLHTDLRAHLDHEEREALALMDLTMSPEEWQAFSVEQKNRIGSDANRYLPWLLDDIDAARVATILGKLPPPLRAAYETEWRAAYEDLDIWAVKDAAELHAVKDAAGR
>NC_021177.1|WP_015610243.1|4461804_4463172_+|cation/H(+)-antiporter
MAAATDPLPDLLIAIPAVILLCKVGARVVRGAGQPPVVGEIAVGLLLGPSFLGWLWPGAQAWLFPPSSLPYLGLLGNLGLLIFMFLVGHEIQLGSLKAQSGTAALVSMVSVALPLGLGTLLALGMYDSFAPEGVDRLPFVLFIAVAMSITAFPVMARILADRGMYRTRVGVLALACAAFDDVTAWCLLAAVVAVSAAGSPMEAVTTALFAIGFALFMFGVLRPVLARLTARAERTSTDSLVLVLLFSGLCLSALATDLIGVHALFGAFVFGAVTPRGSRVIEFQAARLRAFAVPVLLPLFFVTTGLRADVSLLAADPVQWLWAGAVLAVAVLAKWGGGTGAARLSGQSWRDAMSIGALMNCRGLTELIVLNVGLGLGVIGQDLFTILVLMALITTAATSPALNLIRKGMPEEELEVERRPADEAADDSRQPDVSRQPDGSPDAVGARAGGAGPAS
>NC_021177.1|WP_043972819.1|4461189_4461771_+|NAD(P)H-dependent-oxidoreductase
MNSPVPPVKVVVVVASVRAGRLAPDVAGWFTSVAGVRDDLVLDVVDVADHELPGSLDASDPVAADLRPRLSVAEAFVLIAPEYNRSVPGPLKTLIDSFQAEWEAKPVGFVSYGLSLAGGVRAVEHLRQIFAEFHAVGMKDAVLFPRILEHYDAQGRFPAEPEGAEAAAKLLLDQLLWWARALRDAKSVRPYGS
>NC_021177.1|WP_015610241.1|4460766_4461168_+|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MPINRRVARFNKAVANHFVGPVLSRMPGFGKVHHHGRRSGRAFTTPVKLFRRGEDIIITLPYGPGSDWVKNVLAEGGCEITTRGRRIKVTAPVVFTDDGSTKMPALTRRILSRVDATQFLSLTPVAARSAAAG
>NC_021177.1|WP_015610251.1|4472203_4473670_+|Oxygenase-like-protein
MDAQVIVAGAGPAGMMLAGELRLAGADVIVLEKLAARTGESRGLGFTARTMEIFDQRGLLSRFGDIEISNVGHFGGLPVDFGVLRGAHQAAKTIPQSATETVLEEWATQLGADIRRSHELLSVTDKEDCVEVEVRGPEGVHTLRADYLVGCDGGRSTVRKAAGFDFPGTAATMEMFLADVKGITLAPRMIGETLADGMVMVGPLPGGTTRLIVCERGTPPQRRETPPSWKEVADAWQRLTGDDISHAEPVWVSSFGDATRHATEYRRGRIFLSGDSAHIHLPAGGQGMNTSIQDSVNLGWKLAAVVRGRAPETLLDTYHAERHPVGKRLLMNTQAQGLLFLSGAEVQPLRDVLHELIRYPEVSKHFAAMVGGLDIHYELDGGAHPLLGLRLPHVPLEGPGQPASSTEALRRGRGVLLDLADNAELRRRAAPWVDRVDLITATVPGPTAGCLGDTSALLLRPDGHVAWAAPGSFADLPMALDRWFGPAR
>NC_021177.1|WP_015610252.1|4473765_4474095_+|TcmI-family-type-II-polyketide-cyclase
MHSTLIVARMNPGSSQEVARLFRDFDGTEMPHLMGTRRRQLFSYRDLYFHLQDFDAENGGELIEAAKTDPRFQRISDDLKPFIEAYDPATWRSPADALATRFYDWEGRG
>NC_021177.1|WP_031124558.1|4474112_4475387_+|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein
MTGPRRVVITGVGVTAPDGIGAKSFWSLLSEGRTATRGITFFDPSAFRSRVAAEIDFDPEAHGLSPQEIRRMDRAAQLAVVTTREAVADSGLDLTALDPYRTGVTIGSAVGATMGLDEEYRVVSDGGRLSHVDHTYAVPHLYNYLVPSSFAAEVAWAVGAEGAATVVSTGCTSGIDAVGQAVELIREGSADVMVAGATDAPISPITLACFDAIKATTPRNDDAEHASRPFDGTRNGFVLGEGSAVFVLEELESARRRGAHIYAEIAGYASRCNAFHMTGLRADGAEMAEAITVALAEARLNAESIDYVNAHGSGTKQNDRHETAALKKSLGDHAYRTPVSSIKSMVGHSLGAIGSIEIAASVLAMEHHVVPPTANLHTPDPECDLDYVPLTAREHRTDTVLTVGSGFGGFQSAMVLARPDRSES
>NC_021177.1|WP_043974670.1|4475449_4476646_+|ketosynthase-chain-length-factor
MVTGLGITAPNGLGAEAYWDAVRVGKSGIGRITRFDPSQYPARLAGEVPGFTASEHLPSRLMAQTDHMTRLALVATDWALADAGVVPADLPAYSMGVVTASSSGGFEFGQGELQKLWAEGSQYVSAYQSFAWFYAVNSGQISIRNGMKGPSGVVVSDQAGGLDALAQARRQIRKGTSLVVSGSVDASICPWGWVAQLAGGRLATGDDPDSAYVPFDAAAAGHVPGEGGAILIMEDEAAARERGATVYGHIAGYGSTFDPAPGSGRPPGLRKAIELALTDARLDAADIDVVFADAAAVPELDRAEAEALNAVFGPRGVPVTAPKTMTGRLYSGAAPLDVATAFLAMREGLVPATVNVEPDPAHQLDLITGQPRVLPVRNALVLARGHGGFNSAVVASAL
>NC_021177.1|WP_015610255.1|4476686_4476959_+|acyl-carrier-protein
MDNNQTFTLESLKRILREGAGADESVDFDGDILDADFEELGYESLAILETCGRIEREYGITLDDSVVSDVRTPRRMVEVVNEHLGQTAPA
>NC_021177.1|WP_015610256.1|4477142_4477928_+|3-oxoacyl-ACP-reductase-FabG
MPGNARPVALISGATSGIGLAVARLLATQGHRVFIGARDAENVAATVKSLREEGLEADGTVLDVRSPDSVDTFVRTAVERFGTVDVLVNNAGRSGGGVTADLDDELWNDVMETNLTSVFRLTRAALNTGGMRHKDRGRIINIASTAGKQGVVLGAPYSASKHGVVGFTKALGNELAPTGITVNAVCPGYVETPMAQRVRAGYAAAYDTSEDAIMQKFTAKIPLGRYSTPEEVAGLVGYLASDTAASITAQALNVCGGLGNF
>NC_021177.1|WP_043974672.1|4477987_4478932_+|cyclase
MTDSRPREVEHEITVSAPAAEVYRLIAEVENWPRIFPPTIYVDHIERSEGEELIRIWATANGEAKNWTSRRFLDREAMRITFRQQVSTPPVATMGGTWIIEPLSATESRIRLQHDYTAVDDDPAGLAWIEEAVDRNSRSELAALKTNVELATASEELTFAFEDTVEIAGSAKDAYDFINEAGLWSERLPHVAVVRLTEDSPGLQTLEMDTRAKDGSVHTTKSYRVCLNGEKIAYKQTTLPALMNLHTGVWTFRETGAGVAATSQHTVVIRAENIEKILGPEADVAQAREYVKAALSTNSRATLGHAKDYAEARR
>NC_021177.1|WP_043974675.1|4479071_4481438_+|SDR-family-oxidoreductase
MLAGELRLGGADVIVLDRLGAPTTESRASTLHARTMEILDQRGLLDGIGTPPDEPMGHFGGLPLDLRLPGPYPGQWKVPQTRTEAVLGAWAVRLGAEVRRGHRVTGLEQHPDRVTVEAAGPEGGAPVRITAPYVVGCDGEESTVRRLTAIAFPGNDAERELIRADIAGIDIRGRRFERLPRGLAIAARRPDGVTRVMVHEFGRTPRAAEASFADIVDAWHNVTGEDLSAGTPLWVNAFGDVSRQAERYRHGRVLLAGDAAHAQMPIGGQALNLGLQDAVNLGWKLAAAARGRAPARLLDSYHEERHEVGRQVLSNIRAQARLLLGGPEVTGLRAVIGELLPYEAVRARLAGMVSGLDIRYGGALTDAGRPGGGPHGSAGWRLPPMTLNLRSPGAISAYGPESEGSPVQTAALLRDARGVLLVTADEEERRELLTGVAGPFGRSVDAVTVFRPAGDPGGPEGLLDGVDAVLVRPDGYVAWAGTSPAGLEAALATWFVRDTRHSASPTTPSITPRTTSSTTPRTTPHTRSHIVRRENMGKLTGKTALVTGASRGMGRATAERLAREGALVAVHYATGADAAAETVERIEKDGGRAFAVQAELGVPGGVHELFLGLEEGLKERTGSTELNILVNNAGVMGGVAAEDTTPEQFDRIFAVNAKAPFFIIQRALTNIPDGGRIVNISSGLTRFANPDEIAYAMSKGAVEMLALHFAKLLGPRNITINSVAPGITRNSNPVFDIPEAVTAMAGLSTFNRVGEPEDVADVIAFLVSDDARWVTGSFVDASGGTLLG
>NC_021177.1|WP_015610259.1|4481506_4483081_+|MFS-transporter
MTSSPLLPSHTAPAPAHARWSPRMWGLLVVLAGNMLIDALEVSVALVALPAIGTDLGAPLTTMQWTITGFAVGFGGLMLFGARAVALLGRRRVYLAALVGFAAASLVGALAEDPSLLTATRVVKGFCAALTAPTGLAIIATAFPEGPQRNRALSVYTLFGAGGFTAGLLLSGWLTGFSWRLTFAFPAPAVLVLFVLGLRLIPGAGEENGGGPPPGTTDGDRVGRPPGTMTGDRVGRPPGPPAGDRAGRPPRPPLRRYGFASAAAFLAGLLALVQGITSVPAHGWADLRSAGLLALAAGLLALFVALERASAHPLIRFEALRSRAMIRSALGAACLNGSYLGLLFVLTHQLQSLAGWSPLRTAAAFLPAAAPLVVTALFSGRIVARFGAPRLIAAGALLPFAGYLLLLRTPWPPAYATGILPTMLLVGAGFVLSFAALNSQATSQLPPAERGAGSGLYQTAVQVGAALSVALVAALLTGSAPPAGADPAEFAEACRPALTLVAAVGGLGLLTALTGLRSRRTGPP
>NC_021177.1|WP_015610260.1|4483150_4484059_+|4'-phosphopantetheinyl-transferase-superfamily-protein
MDTAHAPAPDPVPTRPAPGHVDVWLVRPPLPGRPPADHHTPWPSGPSHAPQPSGPSHTPRPPGLSAAELRRAASFARPADRAAYATAHTALRQLLGRYLDRPPAALTFVREPCPGCAGPHGRPAVVQAGGGPPLHFSLAHSRGLIAVAVAPRVIGVDVERLPSPETVEACARALHPGEQAELAAAPPGERRAHFGRLWTRKEAYLKALGTGLSRHPRTDYLGSDLSRRPARWAVLDLPAGPEHAAAIAVPGDRPDHITVRWLPAELPYGEDAPYGEDAPGANPGGTVTRSPRSGSTITRSSR

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Crispr_ID: NC_021177_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_12

4558821-4558920

Orphan

Consensus_repeat	Method
ATTCCAGCCCCTCCGGCGTTTGAGGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_12

>merge|NC_021177|12|4558821-4558920|CRISPRCasFinder
ATTCCAGCCCCTCCGGCGTTTGAGGAGGGTGGGTGCGCTCTGCGGGCCATGCGTGACGGGACCGGGGCTCGCAATTCCAGCCCCTCCGGCGATTGAGGAG

>NC_021177|12|12|4558821-4558920|CRISPRCasFinder
ATTCCAGCCCCTCCGGCGTTTGAGGAG	GGTGGGTGCGCTCTGCGGGCCATGCGTGACGGGACCGGGGCTCGCA
ATTCCAGCCCCTCCGGCGATTGAGGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_031124637.1\|4549680_4550187_-\|flavin-reductase	unknown	unknown	gnl\|CDD\|214900
NC_021177.1\|WP_015610345.1\|4568205_4568331_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610332.1\|4552374_4553379_+\|carbohydrate-binding-protein	unknown	unknown	gnl\|CDD\|271149
NC_021177.1\|WP_015610328.1\|4548388_4548964_-\|TerD-family-protein	unknown	unknown	gnl\|CDD\|376767
NC_021177.1\|WP_043972879.1\|4568378_4570265_+\|asparagine-synthase	unknown	unknown	gnl\|CDD\|238949
NC_021177.1\|WP_015610336.1\|4557078_4558356_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NC_021177.1\|WP_015610341.1\|4562656_4563949_+\|threonine-synthase	unknown	unknown	gnl\|CDD\|236065
NC_021177.1\|WP_015610338.1\|4559025_4559883_+\|trehalose-phosphatase	unknown	unknown	gnl\|CDD\|319767
NC_021177.1\|WP_015610340.1\|4561384_4562335_-\|glucosyl-3-phosphoglycerate-synthase	unknown	unknown	gnl\|CDD\|237556
NC_021177.1\|WP_015610342.1\|4563984_4564263_+\|MoaD/ThiS-family-protein	unknown	unknown	gnl\|CDD\|340594
NC_021177.1\|WP_106960130.1\|4567206_4567665_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610331.1\|4550575_4552231_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NC_021177.1\|WP_003967346.1\|4564703_4564910_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_021177.1\|WP_015610329.1\|4549189_4549624_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|181730
NC_021177.1\|WP_015610339.1\|4559890_4561282_-\|trehalose-6-phosphate-synthase	unknown	unknown	gnl\|CDD\|340820
NC_021177.1\|WP_015610335.1\|4555750_4556683_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NC_021177.1\|WP_015610343.1\|4565277_4566900_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NC_021177.1\|WP_015610337.1\|4558379_4558700_+\|DUF3263-domain-containing-protein	unknown	unknown	gnl\|CDD\|378688
NC_021177.1\|WP_015610334.1\|4554593_4555751_-\|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl\|CDD\|238434
NC_021177.1\|WP_015610333.1\|4553462_4554389_-\|1-phosphofructokinase-family-hexose-kinase	unknown	unknown	gnl\|CDD\|274464

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_031124637.1\|4549680_4550187_-\|flavin-reductase	gnl\|CDD\|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	8.03101e-47
NC_021177.1\|WP_015610332.1\|4552374_4553379_+\|carbohydrate-binding-protein	gnl\|CDD\|271149	cd04083, CBM35_Lmo2446-like, Carbohydrate Binding Module 35 (CBM35) domains similar to Lmo2446. This family includes carbohydrate binding module 35 (CBM35) domains that are appended to several carbohydrate binding enzymes. Some CBM35 domains belonging to this family are appended to glycoside hydrolase (GH) family domains, including glycoside hydrolase family 31 (GH31), for example the CBM35 domain of Lmo2446, an uncharacterized protein from Listeria monocytogenes EGD-e. These CBM35s are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH catalytic modules with their dedicated, insoluble substrates. GH31 has a wide range of hydrolytic activities such as alpha-glucosidase, alpha-xylosidase, 6-alpha-glucosyltransferase, or alpha-1,4-glucan lyase, cleaving a terminal carbohydrate moiety from a substrate that may be a starch or a glycoprotein. Most characterized GH31 enzymes are alpha-glucosidases.	3.03456e-09
NC_021177.1\|WP_015610328.1\|4548388_4548964_-\|TerD-family-protein	gnl\|CDD\|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	3.52408e-116
NC_021177.1\|WP_043972879.1\|4568378_4570265_+\|asparagine-synthase	gnl\|CDD\|238949	cd01991, Asn_Synthase_B_C, The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the assembly of asparagine from aspartate, Mg(2+)ATP, and glutamine. The three-dimensional architecture of the N-terminal domain of asparagine synthetase B is similar to that observed for glutamine phosphoribosylpyrophosphate amidotransferase while the molecular motif of the C-domain is reminiscent to that observed for GMP synthetase .	2.76913e-20
NC_021177.1\|WP_015610336.1\|4557078_4558356_+\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.00489e-49
NC_021177.1\|WP_015610341.1\|4562656_4563949_+\|threonine-synthase	gnl\|CDD\|236065	PRK07591, PRK07591, threonine synthase; Validated.	0
NC_021177.1\|WP_015610338.1\|4559025_4559883_+\|trehalose-phosphatase	gnl\|CDD\|319767	cd01627, HAD_TPP, trehalose-phosphate phosphatase similar to Escherichia coli trehalose-6-phosphate phosphatase OtsB and Saccharomyces cerevisiae trehalose-phosphatase TPS2. Trehalose biosynthesis in bacteria is known through three pathways - OtsAB, TreYZ and TreS. The OtsAB pathway, also known as the trehalose 6-phosphate synthase (TSP)/ Trehalose-6-phosphate phosphatase (TPP) pathway, is the most common route known to be involved in the stress response of Escherichia coli. It involves converting glucose-6-phosphate and UDP-glucose to form trehalose-6-phosphate (T6P), catalyzed by TPS, the product of the otsA gene, this step is followed by the dephosphorylation of T6P to yield trehalose and inorganic phosphate, catalyzed by a specific TPP, the product of otsB gene. This OtsAB (or TSP/TPP) pathway, is also the most common route known to be involved in the stress response of yeast In Saccharomyces cerevisiae, the corresponding enzymes, TPS1p and TPS2p, form a multimeric synthase complex together with additional regulatory subunits encoded by Tsl1 and Tps3. Trehalose is a common disaccharide accumulated by organisms as a reservation of carbohydrate and in response to unfavorable growth conditions. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.20986e-30
NC_021177.1\|WP_015610340.1\|4561384_4562335_-\|glucosyl-3-phosphoglycerate-synthase	gnl\|CDD\|237556	PRK13915, PRK13915, putative glucosyl-3-phosphoglycerate synthase; Provisional.	8.96057e-169
NC_021177.1\|WP_015610342.1\|4563984_4564263_+\|MoaD/ThiS-family-protein	gnl\|CDD\|340594	cd17074, Ubl_CysO_like, ubiquitin-like (Ubl) domain found in Mycobacterium tuberculosis CysO and similar proteins. CysO, also termed 9.5 kDa culture filtrate antigen cfp10A, together with CysM (Cysteine synthase M), forms a protein complex CysM-CysO that represents a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. The replacement of the acetyl group of O-acetylserine by CysO thiocarboxylate to generate a protein-bound cysteine is catalyzed by CysM in a pyridoxal 5?-phosphate (PLP)-dependent manner. The family also includes QbsE that functions as the sulfide donor for the biosynthesis of thioquinolobactin in Pseudomonas fluorescens. A JAMM motif protein QbsD catalyzes removal of the carboxy-terminal dipeptide from QbsE. Both CysO and QbsE are similar to prokaryotic sulfur carrier proteins such as ThiS and MoaD, containing the beta-grasp ubiquitin-like fold.	2.12738e-41
NC_021177.1\|WP_015610331.1\|4550575_4552231_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	6.05598e-43
NC_021177.1\|WP_003967346.1\|4564703_4564910_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.38897e-34
NC_021177.1\|WP_015610329.1\|4549189_4549624_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|181730	PRK09256, PRK09256, aminoacyl-tRNA hydrolase.	6.33394e-57
NC_021177.1\|WP_015610339.1\|4559890_4561282_-\|trehalose-6-phosphate-synthase	gnl\|CDD\|340820	cd03788, GT20_TPS, trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.	1.03236e-141
NC_021177.1\|WP_015610335.1\|4555750_4556683_-\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	4.11399e-59
NC_021177.1\|WP_015610343.1\|4565277_4566900_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NC_021177.1\|WP_015610337.1\|4558379_4558700_+\|DUF3263-domain-containing-protein	gnl\|CDD\|378688	pfam11662, DUF3263, Protein of unknown function (DUF3263). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.36635e-29
NC_021177.1\|WP_015610334.1\|4554593_4555751_-\|N-acetylglucosamine-6-phosphate-deacetylase	gnl\|CDD\|238434	cd00854, NagA, N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.	7.81727e-157
NC_021177.1\|WP_015610333.1\|4553462_4554389_-\|1-phosphofructokinase-family-hexose-kinase	gnl\|CDD\|274464	TIGR03168, 1-PFK, hexose kinase, 1-phosphofructokinase family. This family consists largely of 1-phosphofructokinases, but also includes tagatose-6-kinases and 6-phosphofructokinases.	7.21315e-109

>NC_021177.1|WP_015610337.1|4558379_4558700_+|DUF3263-domain-containing-protein
MTAPDAEPASEPEPASPVGPEPSGPAGPAPADRELSVRERAVLALERRSWAGPGAKERAIREELGISPVRYFQLLNALIEDERALREDPVTVNRLRRLREARRDRR
>NC_021177.1|WP_015610336.1|4557078_4558356_+|extracellular-solute-binding-protein
MGEAVQRRFTVLTAVVAALGMTATLSGCGGDSGTGDVTLKLVAADYGNSAANSSEKYWSGVAAGFEKEHPGIKIDVSVYSWKDVDRKVAEMVKAGKAPDIAQIGAYADYAKDGKLYSADQMLSIRTQANFLPTLTDAGKVDGTLYGLPFVASTRLLFYNEKLFGQAGLDAPETWDDIQKDATALKAKGVEYPFALPLGQEESQAETLMWLLSNSGGYVDDVGLYDIDSAQNIATFSWLRDNLVGKGLTGPVEPGKLDRAKAFEAFTNGDVGMLNGHPTLMEEAEAKGVKVGMVPLPGAEGPTKGSMGVADWMMGFKQNGNRKAIGEFFDYAYSDENVLAFADEYDLLPVTGSASAEMETDAKHAKLREFLAALPNSQLPPFGKTSWATVSEAIKTNIGDAVAPGGSPERVLGSIAAEATKAESAE
>NC_021177.1|WP_015610335.1|4555750_4556683_-|ROK-family-protein
MRHVIALDVGGTGMKAALVGTDGTLLHEARRATGRKRGADAVVETILAFAADLRAYGEEHFGEGAVAAGVAVPGIVDAEKGIAVYAANLGWRDVPLRALLGERLGGIPVALGHDVRTGGLAEGRIGAGRGADRFLFVPLGTGIAGAIGIGGTIEAGAHGYAGEIGHIVVRPDGPDCGCGQRGCLETLASAAAVTRAWAAASGDPEADAADCAKAVESGDPAAIAVWRDAVDALAAGLVTALTLLDPRTLIIGGGLAEAGETLFTPLRAAVEERVTFQKLPHIVPAALGDTAGCLGAGLLAWDLLSTEVSA
>NC_021177.1|WP_015610334.1|4554593_4555751_-|N-acetylglucosamine-6-phosphate-deacetylase
MAGRAADSTVLAGARVVLPTGTVENGRVTVESTRISGSAPEDARIVDLTGHWVVPGFVDMHNHGGGGASFTSGTVDEVLHGIRTHREHGTTTLVASTVTGEMDFLARRAGILSELVEQGDLAGIHFEGPFISPCRKGAHSEALLRDPDPAEVRKLMDAARGTARMFTLATELPGGIDSVRLLAEHGIIAAIGHTDATYEQTVEAIDAGATVATHLFNAMPPLAHREPGPIAALLEDDRITVELINDGTHLHPAILELAYHHKGAGRVALITDAMDAAGFGDGQYQLGPLAVSVTDGVARLVEGGSIAGSTLTLDTAFRRAVTIDRIPVEDVVRSISANPARLLGVDDRVGSLEPGKDADLVVLDEDFVLAGVMRKGEWIIEPKTA
>NC_021177.1|WP_015610333.1|4553462_4554389_-|1-phosphofructokinase-family-hexose-kinase
MILTVTLNTALDVTYTVDALVPHSSHRVGEVSERPGGKGLNVARVLGALGHDTVVTGFVGGATGGVLRDLLAPLPPRDALVPVAGNTRRTLAITDRSTGDTTQLNEPGPQVSSAEWATFLRTYEELVGAADAVALCGSLPPGIHVGAYAELVRIARAASVPVLLDTSGEPLRRGIAARPDLVKPNADELAQLTGFREPLRAAGDARRRGAHAVIASLGPEGLLAVTPQGTWRAAPPAAVRGNPTGAGDSAVAGLLSALAEGLDWPGRLARAVALSTATVLAPAAGEFDAEAYAELLPRVSVESVGEAA
>NC_021177.1|WP_015610332.1|4552374_4553379_+|carbohydrate-binding-protein
MTAGNNGASKPEDDDPFGYLYADGQAAGAQPPGQGGYGYPGPAAQPGVPRTSYNQVRTVGERQYGQQQVPPQQGYGYPPQQNYGQPAQQYNAPNPQYAAPETYPGGAPTAHHGSVPGGGSGGRGGPNTKALLIAAVAVVAVVLIGIGAALLSGDNGDKDKKNNEAVSSEGPADKAEESGKPDKKPEETPKPVELPKQDAATLTLGGSASLDSTVKGAKGANGNYINLNEVGRSATWTVDVPEAGPYTLYVTYGVPGKDAKTTLTVNAQEPRSINMKNFAKAAEGDLEKGWTNTYAYVQLDKGSNTLKLSCETGDQCDANLDQLELKSGHIKSNG
>NC_021177.1|WP_015610331.1|4550575_4552231_+|diguanylate-cyclase
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQTVADGIVTGLGYELGCVNLVRPDGDLVIAAFAGNAAAEALITGRVGSRDSWERRLSMGEAWDQLRFIPHTEGWVLLDDDVPQWHTEGPEPRFEDEWHPLDRLYAPMYASGGGRDLLGVISVDRPRNGRRPGAWGREALQMYASQAAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLRTNDALCRLLGRPASVLRRYSFADLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYLWVSLRNSVVADTADGPRFLLTHVEDIEERKRHELNLAHRASHDALTGLPNSAELKSRLSARICERPNSPAATAIEALDAAYGDVESSLTHGYQADGYEGEAAAAGGLYDHHVHAVAPDAENDDGTKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLSTCVRDGDTVARLGGDEFVVLADGLGAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMSVEEVLRSADQRMYVEKRSRSKVHRRAG
>NC_021177.1|WP_031124637.1|4549680_4550187_-|flavin-reductase
MSNDEFRAALARLAAGVVLVTAQEPPLDEEGRGEDVGMTATAFMSVSLDPPLVMVSLRNDSRMDDLLDEQPLWAVSVLAASQRHIAGRFAMKGRISDRLLFEDLAYVRGEVTHAPLIGGALATLECRTEQRVVAGDHTLVIGRVLTAELPSPDGEPLTYFKGRYRQLG
>NC_021177.1|WP_015610329.1|4549189_4549624_+|aminoacyl-tRNA-hydrolase
MGVMSGPYVIRGSVSLPEAELMWRFSRSSGPGGQHVNTSDSQVELRFDLAATDALPDVWKARALERLAGRLVGGVIAVRASEHRSQWRNRETAAVRLAALLAEATAPPPKPRVKRKIPRGINERRLREKKQRGDTKRGRSGRDW
>NC_021177.1|WP_015610328.1|4548388_4548964_-|TerD-family-protein
MAVSLSKGGNVSLTKEAPGLTAVTVGLGWDVRTTTGTDFDLDASAIAVTPAGKVVSDGHFVFFNNKSTPDQTIVHTGDNVTGEGEGDDEQINVNLAGLPADVDKIVFPVSIYDAENRSQNFGQVRNAFIRILNQAGGAEIARYDLSEDAATETAMVFGELYRNGAEWKFRAVGQGYASGLSGIARDFGVNL
>NC_021177.1|WP_015610338.1|4559025_4559883_+|trehalose-phosphatase
MGSHSVQPPIPTPTTPAGREGLEAILARPDRAVIALDFDGTLADIVPDPERARAHPGAVEALAALAPKVASVAVITGRPAGVAVRYGGFAGVPGLDHLVVLGHYGAERWDAATGTVNAPAPHPGVAAARAELPGVLHEFDSWHGTWIEEKGQAVAVHTRRAEDPQAAFETLRGPLGELAAMHGLILEPGRQVLELRPPGMDKGVALATYVAEVDAESVLYAGDDLGDLAAFAAVEKLRGDGPDGIPGLLVCSGSAEVPELAERADLLVPGPAAVVDFLAALAARL
>NC_021177.1|WP_015610339.1|4559890_4561282_-|trehalose-6-phosphate-synthase
MVSEHAPSSTAQVLVASNRGPITYTLGEDGTLDAKRGGGGLVSGLSAVDDKLWVCAALGDGDREAVRRGVGEPGVRMLDIDAEVHADAYNGIANSVLWFVHHLLYQTPVEPVFDAEFRRQWASYETYNRAFARALAEEAGPGAAVLVQDYHLALVPGMLRELRPDLRIGHFSHTPWAPVDYFRLLPDDIGEQLLRGILGADRAAFLTRRWADAFISCCTEVLGGTGRTRIGVHGLGADADFLRRRSQEADVDERMAALREQVGEGRKTIVRVDRTELSKNIVRGLHAYRTLLETHPEWRERVVHVAFAYPSRQDLAVYRDYTAAVQTLATEINGAYGTESWTPVVLHVKDDFARSLAAYRLADVALVNPIRDGMNLVAKEVPVVSDHGCALVLSREAGAYEELGEDAIVVNPYDVVGTAEALHEALSMSAEERTGRTKRLAEAATALPPQQWFLDQLEALRQE
>NC_021177.1|WP_015610340.1|4561384_4562335_-|glucosyl-3-phosphoglycerate-synthase
MLEEVERWLTRRSWSSADRPLDRLTDARDAEPHRTSVSVVLPALNEEATVGAIVATIRRELMEKVRLVDELVVIDSGSTDATAAVARAAGARVVHRDAILPRIPALPGKGEVLWRSLLVTSGEIVCFIDADLKDFSADFVSGTVGPLLTDPTVQFVKAMYDRPFGDSAGQGGRVTELVARPLLNLHWPQLAGFVQPLGGEYAVRRSLLERLPFPVGYGVELGLLVDALHTVGLDALGQVDVGVRRHRHQDGQALGRMAAAIYRTAQLRLSRGHLVRPALTQFERGEEGFVPRTHAVDTEERPPMREIAEYAERWAA
>NC_021177.1|WP_015610341.1|4562656_4563949_+|threonine-synthase
MAVQTIAENTTSSVDLGPAAALSCRECGERFELGPLFACASCFGPLEVAYDLPAGSPEELRKRIEAGPNNIWRYAPLLPVPADVAEKPNINPGFTKLVKADNLARELGVTGGLYVKDDSGNPTHSFKDRVVAIAVEAARAFGFTTLSCSSTGNLAGAVGAAAARAGLRSCVFIPHDLEQGKVVMAAVYGGELVGIEGNYDDVNRFCSELIGDPLGEGWGFVNVNLRPYYGEGSKTLAYEICEQLGWKLPDQIVIPIASGSQLTKIDKGFQELIKLGLVEEKPYKIFGAQAEGCSPVSAAFKAGHDVVRPQKPNTIAKSLAIGNPADGPYVLDIARRTGGAVDDVNDEQVVDAIKLLARTEGIFGETAGGVTLGVTKKLIEAGVIDPTLTTVVLNTGDGLKTLDAVSATSQATATIKPSLDAFRAAGLASA
>NC_021177.1|WP_015610342.1|4563984_4564263_+|MoaD/ThiS-family-protein
MSVKVRIPTILRTYTGGQAEVPAEGAKLSEVIESLEKDHPGIAARVLDDQGKLRRFVNVYVNDDDVRFEGGLETVTPDGAGISIIPAVAGGC
>NC_021177.1|WP_003967346.1|4564703_4564910_+|cold-shock-protein
MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQRVEFEISQGQKGPQADMVKLAVG
>NC_021177.1|WP_015610343.1|4565277_4566900_+|chaperonin-GroEL
MAKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPMALKRGIEKAVEAVSAALLEQAKDVETKEQIASTASISAADTEIGAKIAEAMDKVGKEGVITVEESQTFGLELELTEGMRFDKGYISAYFATDMERMEASLDDPYLLIVNSKIASVKDLIPLLEKVMQSGKPLLIIAEDVEGEALSTLVVNKIKGTFKSVAVKAPGFGDRRKAMLADIAILTGGTVISEEVGLKLENAGLDLLGRARKVVITKDETTIVDGAGDSDQVQGRVNQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLQASAVFDKLDLTGDEATGANAVKLALEAPLKQIAVNGGLEGGVVVEKVRNLPIGHGLNAATGEYVDMIAEGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEKAGAAAPGGMPGGDMDF
>NC_021177.1|WP_106960130.1|4567206_4567665_+|hypothetical-protein
MGTALLAAGLFIVVTGTGLAGPAGLRVETFGRIDCRDTRAEKGQTVRHCFGESPAQQRANEAERERVAREALRAHVDGVPAPAEIGRTRILFADHDGRNDPGTITATQVFDGGRWLAHSSTVVGYGMIPLLLGAGTAAWGGYRVREAGVRRG
>NC_021177.1|WP_015610345.1|4568205_4568331_+|hypothetical-protein
MKLQKKAYVKPSLFKQGDFSKKTAGYFVGSYKEYWVRRIVY
>NC_021177.1|WP_043972879.1|4568378_4570265_+|asparagine-synthase
MPGLPRDYFVVLPDSVAGHAVAGHLPAPDATVVHPSGRPWVLARPLFRKVSHLRRGDDALVLIGPDRVPDAVLSGLLEGARDRAALERRLTRLPGLYHVVARLSGETWIRGTASGLRRIYHAPHTEAGTIASDRPAVLAHLTGAPLDDGALALRMLDFLPHPLSRRVLWRGVHETGAGYGLALPAAAPGTATAPGPREYRWWEPPPAELSLAEGARGVGDAVAASVRAHVGGLDRISCELSGGMDSTSLTFAARATGPETLSLLTVAARDRYSEDETWARRAVEEAANRSTPEAPAPDHHVIPADRAPYFYADLASTAAELNDEPLPVAPGRARAHLLLSAAHATGSRYHLTGYGGDELFLGLPHAYQDLFHGNPFTAWNHLSGLRHQLGWPLLPTVKALLDRSAFPRWIAGAVTAELQPLSRTPLLSWGVRQSLRPWFTDHANALITEEFRAAAEHAEPIHPWRGRHVDIDAVRMGARHFQAMEDIGMTVGLPVAAPFYDDRVLEATLAVRLEERISPWRYKPLLAEAMRGVVPDALLARTTKDHMSSDEHQGLREHAPELAELWTGSRLAEHGLVDARHLLRLAAEPFSPVLVEHSISSTVAGETWLRTAENAWPTSQLTPTTSEA

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Crispr_ID: NC_021177_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_13

4663572-4663654

Orphan

Consensus_repeat	Method
GGCCACCTCGACGCAGTTGCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_13

>merge|NC_021177|13|4663572-4663654|CRISPRCasFinder
GGCCACCTCGACGCAGTTGCCGCTGTTTTCGCCGCTGTAGCTGGATTTGGACCAGGTGAGCGCCACCTCGACGCAGTTGCCGC

>NC_021177|13|13|4663572-4663654|CRISPRCasFinder
GGCCACCTCGACGCAGTTGCCGC	TGTTTTCGCCGCTGTAGCTGGATTTGGACCAGGTGAG
CGCCACCTCGACGCAGTTGCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015610441.1\|4666832_4667168_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610430.1\|4659084_4659525_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NC_021177.1\|WP_015610427.1\|4657096_4658008_-\|RNA-polymerase-sigma-factor-SigJ	unknown	unknown	gnl\|CDD\|236600
NC_021177.1\|WP_032759333.1\|4670283_4670721_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133398
NC_021177.1\|WP_015610431.1\|4659590_4660247_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_021177.1\|WP_078618723.1\|4665053_4665227_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|224937
NC_021177.1\|WP_043972924.1\|4665219_4665423_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610433.1\|4661051_4661813_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610426.1\|4656692_4657019_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NC_021177.1\|WP_015610432.1\|4660317_4660821_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610428.1\|4658104_4658506_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610443.1\|4667680_4668274_+\|Abhydrolase_5-domain-containing-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610440.1\|4665630_4666698_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610437.1\|4663699_4664527_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NC_021177.1\|WP_043972927.1\|4668395_4669898_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NC_021177.1\|WP_043972922.1\|4664608_4665034_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610442.1\|4667234_4667648_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NC_021177.1\|WP_015610435.1\|4662852_4663377_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379324
NC_021177.1\|WP_015610434.1\|4661828_4662680_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_021177.1\|WP_015610429.1\|4658484_4659018_-\|acetyltransferase	unknown	unknown	gnl\|CDD\|379237

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015610430.1\|4659084_4659525_-\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	9.20485e-22
NC_021177.1\|WP_015610427.1\|4657096_4658008_-\|RNA-polymerase-sigma-factor-SigJ	gnl\|CDD\|236600	PRK09636, PRK09636, RNA polymerase sigma factor SigJ; Provisional.	1.60802e-92
NC_021177.1\|WP_032759333.1\|4670283_4670721_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133398	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators. Helix-turn-helix (HTH) heavy metal resistance transcription regulators (HMRTR): MerR1 (mercury), CueR (copper), CadR (cadmium), PbrR (lead), ZntR (zinc), and other related proteins. These transcription regulators mediate responses to heavy metal stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	4.28084e-28
NC_021177.1\|WP_078618723.1\|4665053_4665227_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	7.21005e-09
NC_021177.1\|WP_015610426.1\|4656692_4657019_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.000184206
NC_021177.1\|WP_015610434.1\|4661828_4662680_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.75807e-08
NC_021177.1\|WP_015610437.1\|4663699_4664527_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	7.95509e-10
NC_021177.1\|WP_043972927.1\|4668395_4669898_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.86086e-126
NC_021177.1\|WP_015610442.1\|4667234_4667648_+\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	1.12908e-21
NC_021177.1\|WP_015610435.1\|4662852_4663377_+\|ATP-binding-protein	gnl\|CDD\|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	2.35506e-25
NC_021177.1\|WP_015610431.1\|4659590_4660247_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.24558e-15
NC_021177.1\|WP_015610429.1\|4658484_4659018_-\|acetyltransferase	gnl\|CDD\|379237	pfam13523, Acetyltransf_8, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	3.85224e-27

>NC_021177.1|WP_015610435.1|4662852_4663377_+|ATP-binding-protein
MTTLFLMVGLPGAGKTTRARQLAEEHGALRLTPDDWMLPLFGVAELDGKRDVLEGRMLWLALEAVRVGTNVVVDYGCWSRNERSAIRWLAEAEDARFRMIYLSVDAETQRARIAHRWATAAGETFPMTEADILHGRAHFEEPDAAELAGGPISAPPPGWVGWREWAAARWPSFA
>NC_021177.1|WP_015610434.1|4661828_4662680_+|helix-turn-helix-transcriptional-regulator
MSTDYQQAREALGVRLRELRLSAVGGRLTGTQLAGQAGWNKSKVSRLENGRQTPSPDDLRAWAGATGRPDAYDELLARLRGFESHVRSWRRQLAAGHKAVQDTHLSAHADATVFRGWEPAMVFGILQTPDYARAIFTRYAELQRSPRDTEEAVRSRMQRQQELYDSSKRFHLIMWEAALHALVCPPPVLAAQLDRLAGSIGLDTVELGIIPLSAALKIPPATAFWVYDDRQVIVENWHAELWIDDEVSVETYLRTWKTLRESAVYGADAHRLVNAAREALERR
>NC_021177.1|WP_015610433.1|4661051_4661813_+|hypothetical-protein
MARRLRFNGTGSGVNGCPSLHEDLDTGEVVVHSLPLTEPDDIAQLRHLNDGEVPVVVPRELLVDFGPKEVVRVPDIIGLDEFDRLFTQFEHTAWRLETRRRYASDELTGTYAQFTRGTAVNWDGVDAAWCAERREQAALGKRFERVRIVDAPPTPGQLYLLDNARRNSEVGERIRNLRREDADRLGLPAEDFWLFDSRLVALLNFDDTDNLVDVELITQPAEVLRYAMVRDAAEHHAFPYVELVQQQQAAKGN
>NC_021177.1|WP_015610432.1|4660317_4660821_-|hypothetical-protein
MNVTLHRSTDIVSTRDPKGLLNAVQPRIQHLTVNVLDSGMTLWDREVALLLRDHTMVRDMAERILGNAVMYTVGCMEHPQVHLGVGKLVDLGVHQLILDTPVWWALCEAYNEGRYKHHAPFIERRRDGLCLRTADFLQSIGFDVDEELWAIDGTECSPCDNKVPDSH
>NC_021177.1|WP_015610431.1|4659590_4660247_-|class-I-SAM-dependent-methyltransferase
MPAHHDIAAETDLWNTYAASAFTEDAEPVFCWTQYAGHGPGPEVLGGPRSVLEIGCGTGRALAHLAQRGVVARGVDLSPVMVKKTTAKWAATGAEIVCAEVLEHLREHDVTYDAVYSIFGAAWFADPGRLFPLVRQRLAPGGVFAFSQPPAIPGAYGPQGMYKGGFAGKAMFTYRYSYRPAVWERLLTRAGFATATAEVLDAPHPGHIGTLLVRAVAS
>NC_021177.1|WP_015610430.1|4659084_4659525_-|NUDIX-hydrolase
MTTPLPAPLAESLLAEARRDGIRKYVVGALITDEDGRVLLLRRRPDDFLGGLWELPSGGVDPGERLVDALCREVLEETGLTVTGVTGHAGSFDYASRSGLRTRQFTFAVTVGATGPVALTEHDDSAWADRGGLPAVSDETRALLAG
>NC_021177.1|WP_015610429.1|4658484_4659018_-|acetyltransferase
MITWRRLTEDDFPLLISWLEQPHVARWWNHETSIEAVRRDFGPALRGEEPSEELIAHLDGTPFGLLQRCRLADYPEYLAEVAALIEVPSGAMTIDYLIGEPQLVGRGLGPRMIRSAVQAIWDEHPDAPGVLVPVSAANRASWRALEKAGLLRVAEGEMEPDNAVDDRAHYLYRIDRT
>NC_021177.1|WP_015610428.1|4658104_4658506_+|hypothetical-protein
MATETTTAHHHRFSFLQIAIALQTLTIFVQAVSAGLLFTTTYGEVLHDVGARVMYGASMLYVLAAVLAWKPGGGSPRPIGYAAGFLALASAQVAVGIAHIPSVHLPLGVMMFGLSVLALARPPRPGHQVRSIR
>NC_021177.1|WP_015610427.1|4657096_4658008_-|RNA-polymerase-sigma-factor-SigJ
MGAAGAGIDAVAGERRQLINVAYRLLGSLAEAEDAVQEAYARWYALPRNRRDEILSPGGWLTTVTGRICLDVLGSARARRERYVGAWLPDPLPDRAEWGLVSEGGDPADQMVLDESVAMALLVVLESMTPAERVAFVLHDVFRYPFAEIAAILGRTPAACKQLAASARRRVRDAPGPAAVAGDGRAEAVRRVKDAWERKDIAALIDLLDPAAVMTADGGGLVGTVLRPIEGGARIAQYMVAIADRAPGLELLERSVNGAPGLVARRGGTVMTVASFDVDGDGRITRIWAVRNPEKLRPWLRDG
>NC_021177.1|WP_015610426.1|4656692_4657019_+|nuclear-transport-factor-2-family-protein
MTTSISDPVVERFVAAVNAGDETAFTAVLTEDATMSDDGSERDLAAWTEKEIFSPKANGRMKIVDASDDGRTLVVDYTNDTWGTMRTRWVFTVTGDRISRFETGQAPA
>NC_021177.1|WP_015610437.1|4663699_4664527_-|helix-turn-helix-domain-containing-protein
MHSSDQAETAAEMFGLLLRHFRERAGLSQEQLGKRIGYSKSQVAMVERGARPPKGVFVQRADEELGAQGALIVAAPKPPKAQKQRNPLPGWFTPFAEEEEKAWARHEYENHVMPGLLQTEAYARAVFTSRYPNYDDDEIEAKVAARLERQRLLTRRPLPDISFVLEMVVLTRPIGGRRVMKAQLDHLADVARLRQVRIQLMDPYREDHAALDGPFVLLETDKRQQLAYIEGQGGSFFVTEQPQLGNLFGKYGVTRAQAYTPERTLEKIEKMAEEL
>NC_021177.1|WP_043972922.1|4664608_4665034_+|hypothetical-protein
MELRNSLDPVPSWIPASGHALRHVGIHFDAVRAIGLLGEEIAYEVMQFTDFHAGPIVRSGIGERSMYFLLAPGTAAGHRWPPGVEAMNRNARGAAFVGVPALDGATWPLDWRSRPTAQDPFVDAALLHEMAWLRAGCTVKE
>NC_021177.1|WP_078618723.1|4665053_4665227_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MADPRDLSEFDVKPLQGHHARWRLRVGSYRAVYTVEDGRLIVWVPAVGHRREIYRNL
>NC_021177.1|WP_043972924.1|4665219_4665423_-|hypothetical-protein
MSEPVNASMAEVRKHPADSNDDYRRLREAAERYEDEWLNRLAEQAESEGTEGSVSMEEMAALLRSAG
>NC_021177.1|WP_015610440.1|4665630_4666698_+|hypothetical-protein
MLSHVIPPPRGYTKVPNGLVRQARLGSDAKILVIYVQGLPESDRGKALGEHARALHITGRQYQKAKSELVASGYVHEKRETVAGGRWRTVQVFSNFPLTDDQAARLRAGVPADGYEVVSLGSSGSAPSTHFPTVGAPGGRVAGGQLPADEEPGKNESHPPTEAREGEEAAVEGVGEPSGGGCQESSVGPEVALAERVLLSLRHEQRQLHLGVPEARSIAGLAAEWLRRGVTAADLRRALCNGLPPQGVRTAVGFLAHRLKEKLPAAPESVDPPQPPPGPPALIACAGPGEEHLFRPPVPWATTCGPCHREEQRAFWADALGRGDAAPEPPPWRERFAAFAEGGGVPGVGAEGGAA
>NC_021177.1|WP_015610441.1|4666832_4667168_+|hypothetical-protein
MNGDLLYHWIGLAVSTVVMVPVPVAILAGWTPPWMRKRLAGMRLRAYGVLCIYAHVLVNSVPRIADASFETVMVCMNVGLGFTIACAVLFLLSADKDSGARKIDPVEPREG
>NC_021177.1|WP_015610442.1|4667234_4667648_+|VOC-family-protein
MLRLTDFIIDCPDTMKLAAFYSEVTGLPVKEGSNEHWAGIRFGDIELAFIQVEDYRAPQWPDSEHPKQFHLDFEVDDIEAEELRVLALGATSQRDCIGPNGYGFRVYTDPIGHPFCLCRNKGVVWTDQGPVWPKRDQ
>NC_021177.1|WP_015610443.1|4667680_4668274_+|Abhydrolase_5-domain-containing-protein
MSDPSPFAMPTRFDGDPGRVALVVPGVGYSPARPLLHFAREVLRQHGWTVQELWWHVPDDFAQLPVDERIAWVEWQVGRAVSAEEGACRLIVGKSLGSLASGIAADRGIAAAWLTPLLTFDHVFRALRRAQPPTLLVGGTADKLWDAEVAASLHHDVLEIPSADHGLELPDDVVGSAEVLRQVVSRLDHFVGSLGRA
>NC_021177.1|WP_043972927.1|4668395_4669898_-|SulP-family-inorganic-anion-transporter
MPTSALTPAMRLRGLKPEWLNNPKVWRTEILAGLVVALALIPEAISFSIIAGVDPAVGLFASFTMAVVISIVGGRRAMISAATGAVALVIAPLNREHGLGYLISAVILAGVIQIVLGSLGVAKLMRFVPRSVMVGFVNALAILIFMTQVPEMYDVPWAVYPLLVGGLALMVFFPRLTKAVPAPLVSIVILTAITVAAGIAVPTVGDKGELPSSLPVPGLPDVPFTLDTLATIAPYAFAMALVGLMESLMTAKLVDDITDTHSSKTRESIGQGIANIVTGFFGGMGGCAMIGQTMINVKVSGARTRLSTFLAGAFLMVLCIAFGPVVSDIPMAALVAVMVMVSFATFDWHSIAPKTLKRMPAGEIAVMVITVLVVVATDNLAIGVVVGSVTAMVIFARRVAHLARVTSVTDPDGTTVVYSVTGELFFASSNDLVGQFDYNDDPDRIVIDLSAAHIWDASSVAALDAIETKYKQRGKTVEIVGLNAPSADLHGKLTGELTSH
>NC_021177.1|WP_032759333.1|4670283_4670721_+|MerR-family-transcriptional-regulator
MDDDHMQIGEVAARTELSLRTIRHYEEVGLVIPSARSQGGFRLYTETDVQRLMVIRRMKPLGFTLDEMRDLLDVTDRLDASRPADRTERAELLERMEVYEQTAARKIEELRTQLSRAEDFAATLRARLQNVPGEDPTPRTDAVHS

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Click the colored protein region to show detailed information

Crispr_ID: NC_021177_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_14

4727031-4727240

Orphan

Consensus_repeat	Method
ACACCCCCGCACGCGCGGGGACCACA	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_021177_14

>merge|NC_021177|14|4727031-4727240|CRISPRCasFinder
GCGGCGCCGGGCGCGCGGGGACCACCCGCACCCCGACCACCGGGGCCGCCGGGCAGCGGGACGAGCCCCGCACGCGCGGGGGACCACCAGTCCGCCGGGTCCTGGTCCGACTTCTGCCGGGGGACACCCCCGCACGCGCGGGGACCACAAGTGACCGAGCAAGCTGACCTCCAGCCCGACGGGAACACCCCCGCACGCGCGGGGACCACA

>NC_021177|14|14|4727031-4727240|CRISPRCasFinder
GCGGCGCCGGGCGCGCGGGGACCACC	CGCACCCCGACCACCGGGGCCGCCGGGCAGCGGGA
CGAGCCCCGCACGCGCGGGGGACCAC	CAGTCCGCCGGGTCCTGGTCCGACTTCTGCCGGGGG
ACACCCCCGCACGCGCGGGGACCACA	AGTGACCGAGCAAGCTGACCTCCAGCCCGACGGGA
ACACCCCCGCACGCGCGGGGACCACA

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_043974730.1\|4727775_4728186_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350221
NC_021177.1\|WP_015610491.1\|4711842_4713585_+\|DUF1446-domain-containing-protein	unknown	unknown	gnl\|CDD\|377804
NC_021177.1\|WP_164711296.1\|4721797_4727026_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237537
NC_021177.1\|WP_015610501.1\|4728188_4728425_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227035
NC_021177.1\|WP_015610497.1\|4720931_4721537_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_021177.1\|WP_015610493.1\|4715277_4717293_+\|acetyl-/propionyl-CoA-carboxylase-subunit-alpha	unknown	unknown	gnl\|CDD\|227111
NC_021177.1\|WP_015610505.1\|4731637_4733029_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|365848
NC_021177.1\|WP_015610496.1\|4720209_4720944_+\|enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|236109
NC_021177.1\|WP_015610504.1\|4731164_4731497_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610492.1\|4713581_4715180_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit	unknown	unknown	gnl\|CDD\|178415
NC_021177.1\|WP_015610503.1\|4729966_4730965_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_021177.1\|WP_015610506.1\|4733507_4734122_+\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|378155
NC_021177.1\|WP_043972946.1\|4735061_4735613_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NC_021177.1\|WP_015610508.1\|4734303_4734993_+\|DUF4232-domain-containing-protein	unknown	unknown	gnl\|CDD\|379419
NC_021177.1\|WP_015610495.1\|4718611_4720213_+\|4-coumarate--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|341230
NC_021177.1\|WP_043972941.1\|4727350_4727749_-\|DUF4440-domain-containing-protein	unknown	unknown	gnl\|CDD\|227327
NC_021177.1\|WP_015610494.1\|4717289_4718450_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NC_021177.1\|WP_043972944.1\|4728511_4729531_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_021177.1\|WP_015610489.1\|4710110_4710824_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240026
NC_021177.1\|WP_015610490.1\|4711039_4711846_+\|TIGR03084-family-protein	unknown	unknown	gnl\|CDD\|274423

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_043974730.1\|4727775_4728186_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350221	cd09873, PIN_Pae0151-like, VapC-like PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Pyrobaculum aerophilum proteins, Pae0151 and Pae2754, and homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.37874e-27
NC_021177.1\|WP_015610491.1\|4711842_4713585_+\|DUF1446-domain-containing-protein	gnl\|CDD\|377804	pfam07287, AtuA, Acyclic terpene utilisation family protein AtuA. This family consists of several bacterial and plant proteins of around 400 residues in length. One member of this family has been characterized in Pseudomonas citronellolis as AtuA, a member of a gene cluster that is essential for the acyclic terpene utilisation (Atu) pathway.	1.56142e-171
NC_021177.1\|WP_164711296.1\|4721797_4727026_+\|hypothetical-protein	gnl\|CDD\|237537	PRK13875, PRK13875, conjugal transfer protein TrbL; Provisional.	0.00861589
NC_021177.1\|WP_015610501.1\|4728188_4728425_-\|hypothetical-protein	gnl\|CDD\|227035	COG4691, StbC, Plasmid stability protein [General function prediction only].	0.0077311
NC_021177.1\|WP_015610497.1\|4720931_4721537_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.96258e-11
NC_021177.1\|WP_015610493.1\|4715277_4717293_+\|acetyl-/propionyl-CoA-carboxylase-subunit-alpha	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NC_021177.1\|WP_015610505.1\|4731637_4733029_-\|cytochrome-P450	gnl\|CDD\|365848	pfam00067, p450, Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.	8.10234e-47
NC_021177.1\|WP_015610496.1\|4720209_4720944_+\|enoyl-CoA-hydratase-family-protein	gnl\|CDD\|236109	PRK07827, PRK07827, enoyl-CoA hydratase family protein.	2.40379e-126
NC_021177.1\|WP_015610492.1\|4713581_4715180_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit	gnl\|CDD\|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
NC_021177.1\|WP_015610503.1\|4729966_4730965_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	9.07577e-11
NC_021177.1\|WP_015610506.1\|4733507_4734122_+\|SMI1/KNR4-family-protein	gnl\|CDD\|378155	pfam09346, SMI1_KNR4, SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.	0.00373142
NC_021177.1\|WP_043972946.1\|4735061_4735613_-\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	6.09307e-19
NC_021177.1\|WP_015610508.1\|4734303_4734993_+\|DUF4232-domain-containing-protein	gnl\|CDD\|379419	pfam14016, DUF4232, Protein of unknown function (DUF4232). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	7.74478e-07
NC_021177.1\|WP_015610495.1\|4718611_4720213_+\|4-coumarate--CoA-ligase-family-protein	gnl\|CDD\|341230	cd05904, 4CL, 4-Coumarate-CoA Ligase (4CL). 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.	0
NC_021177.1\|WP_043972941.1\|4727350_4727749_-\|DUF4440-domain-containing-protein	gnl\|CDD\|227327	COG4994, COG4994, Uncharacterized protein conserved in bacteria [Function unknown].	1.39544e-09
NC_021177.1\|WP_015610494.1\|4717289_4718450_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	3.80262e-89
NC_021177.1\|WP_043972944.1\|4728511_4729531_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	5.3359e-06
NC_021177.1\|WP_015610489.1\|4710110_4710824_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240026	cd04669, Nudix_Hydrolase_11, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	4.4436e-20
NC_021177.1\|WP_015610490.1\|4711039_4711846_+\|TIGR03084-family-protein	gnl\|CDD\|274423	TIGR03084, conserved_hypothetical_protein, TIGR03084 family protein. This family, like pfam07398, belongs to the larger set of probable enzymes modeled by TIGRFAMs family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized. [Hypothetical proteins, Conserved].	4.65509e-113

>NC_021177.1|WP_164711296.1|4721797_4727026_+|hypothetical-protein
MSEDTGRAPRLMRPAGPGVLSGGPGSLQGMQQTLGNEATTRAVRRGKRPMAPRPPAIDERAEQGLVLPPYLMELEAGGLSTAYGLTGQEFVSTAVAAVVGHGGGTVAGISAELAGRPESFFGRGRAFAVEGAEGGDGFDVTVSIAPAPDDLPPTFHPAADLASAPPDPGGAPLAAVDDAEGKETKVDVQHNSGATASSTVGNSSSKGAGGTAFGLAPVLPGLWLGAAATGSVQPWQSSRDSRSQRGVAEPRVLRSDKGSVEVPRRVLYVVRVRPQAGGDEQVFRGSGGLTQRVPTEHLIPAGTEAPTLAAPATGAPGRSQQVDPDLARRVALADSLAPVGVSDTAGPHQGGGGLFDAVASVLHPSLTAPGAPGRSRLYEATATPTVLEDLPRLLGGDGVTGDDLYSKDGTSTSSYRMRAVVTGLTPAWGTGKTQLRTHQQAQHTATESAGKGRSVAGGIGPAIGVGAAANAAVVRATAMPVAAARKARFSVNEQTVSSRQGAEVRGEKVLYLGTAQFTVEGTGPRSVRAILNPQARVATHAMRVWIGLRADEAQELGLPLPPGVTAGEFIKKPEPQHPAADTDSDTDSDTESESEGGGDARHLPFGAMGSSVTIGRLDTAPMVKAVREMFATDPRLAGYLPAFGATPPPADLSREEDEAQRTNYRELMAALSEANLRVNKEQLLSTGIRVRLRRKTTMHSHDVQLRVHGTMGATRHLGEIDDWLVRAHSGVAANAQSGRSSSRSIGGMVLAQARLIPGVLTGSARYERQSSGTRRNQGGPTTRTDVLTNGSEKASAFGAALRLNVDVTMTSRQRKLARALTPGGPGRDVPEAKLLTGLHMEEQDVRLLTPSEFTVGTDEKARLDAGADQAPGPERPVAGAAGIGDLAGLAPTPAAGQVVRDWQLVETLGDGQPVRDLALALLSRAAARGEAGRQDTALATEGLAPRLAVEERFSPRAITAALRQAASSGWVVKNLRYPRRLAALNGAVGTRLALAAPQLVHEAAGPGTETFVMGGHQAGGQQGEGTSSTVQVGVTGVQNGTEWRVGEGLSGYRSTSRSDTESATVSGTVERNAHTPKKAPLYLVRCDLLVTMVAEVKVTGGGPYVASAARTLPGAAAVWLTAEQLRAAGVDLPESARKALKVEDRRPAAERTAEGSGGGERGGASTAASTSASTPAPAPAPARERERERARASASASASTSTGGQAARPARPARQGPALARELPLGFGMIEDLPDFVPLLDRLRGNLAITGQQDLADDLLPRQQLRDRNDNVQRLLRVLDRDGSTGLLASAMDGGVTVELLDGRNTPYWAVFKIVRSGDGVREGEADDGRDMEYITSAAAQQATSHGEGETTGVEGILAGSGKPDAGAGQVKSAGAAAGLGVASGSGRRGGEAARGQLGMKTVAEAKTAKSAKMRVPIVASLELHKGESRLAMAGSGRTSLVHRILESDLTALRRVSAPRRAPRPAPGVPTSGVAGLGAWRADGIPLPMEAQVNGFQGAAHVRELVNTAVRAAGGGDRFRQKGQAAAYTLGEAVSTEWLIAALPLLTHAGAELPPVHASGAAGQDLQASVHARLRAGRILGAGDKMTFETAAQSSLGAPRPTQTEGQSQAEQSRQARGLFGAGVLNADQFRLNQLMGNVDGAGSASGAAANGAGSMPLHKPKFTSVLVQFTLDVRVVARVTNRVRTSRTEMAERDLTLPRPVVIRMPLPVAGRLLAAHPTEITDQHDRLGLRAAAVPPPTGV
>NC_021177.1|WP_015610497.1|4720931_4721537_+|TetR/AcrR-family-transcriptional-regulator
MGAVTSSSVARSAHAPKQDRSRATRQRLLEAAVACLAEHGWAGSTVSVVAERAGVSRGAAQHHFPTREDLFTGAVEYVAEERSAALRALPVQGRAEVVAALVDLYTGPLFRAALQLWVAASNEEQLRPRVTELEARVGRETHRIAVELLAADESRPGVRETVQGLLDMARGLGLANLLTDDTARRARVVAQWAALVEEGLG
>NC_021177.1|WP_015610496.1|4720209_4720944_+|enoyl-CoA-hydratase-family-protein
MTLIVRTGERGVATLTLDSPANRNALSAALVGELRESLARCASDDTVRAVVLTHTGTTFCAGADLKAPPDPEVFVGLMREIVALPKPVVARVEGHVRAGGLGLLAACDIAVAGPSSSFALTESRLGLAPAVISLTLLPRMDRTAANRYFLTGERFDAAEAARINLVTLAAEDVDKALVPVLDGLRRASPQGLAASKELVTATVLESFDQYAEDLIARSAALFASEEAREGMTAFLERRDPAWVR
>NC_021177.1|WP_015610495.1|4718611_4720213_+|4-coumarate--CoA-ligase-family-protein
MVFRSEYADVPALDVPIHEAVLGGAAGFGDTVALIDGTNGTSLTYAQLDGFHRRIAAALADAGLRKGDVLALHSPNTIAYPAVFYGATRAGASVTTVHPLATAEEFAKQLADSGAKWIVTVSPLLETARRAAELTGGIQEIYVCDQAEGHTSILDMLASPAPEPEIAIDPGEDVAALPYSSGTTGTPKGVMLTHRSIATNLEQLRPFIPMGEGDRILAVLPFFHIYGLTALMNAPLRCGSTVVVLPRFDLAQFLEAIQTHRITGLYVAPPIVLALAKHPLVGEYDLSSLQYIVSAAAPLDAELAAACSARLGLPPVRQAYGMTELSPGTHVVPLSVEEPPPGTVGKLLPNTEMRIVSLEDPAQDAEPGADGEILIRGPQVMKGYLGRPDATADMIDAEGWVHTGDVGRTDEDGWLYVVDRVKELIKYKGYQVAPAELEALLLTHEHLADAAVIGVYDADGNEVPKAFLVRSPAGEGLTEEDVMAYVAERVSPYKKVRQAEFIDAVPRAASGKILRRELRDREKTDHSGTSEEK
>NC_021177.1|WP_015610494.1|4717289_4718450_+|acyl-CoA-dehydrogenase
MSTVLETEEHQALRAAVAALGKRYGRDYMTTVIREGSHTHELWAEAAKLGYLGVNLPEEYGGGGGGMAELSIVLEELGAAGSPLLMMIVSPAICGTVIARFGTDEQKQKWLPGLADGTLTMAFGITEPDAGSNSHRITTTARRDGTDWLLTGRKVFVSGVDIADATLIVGRTEDARSGKLKPCLFIVPRDAEGFGRNQIDMELHAPEKQFELVLDDVRLPAEALVGDEDAGLLQLFAGLNPERIMTAAFGIGMGRFALGKAVEYARTRQVWKAPIGSHQAIAHPLATAHIDLELSRLMMQKAARLYDDGDDIGAGEAANMAKYAAGEACVKAVDQAVHTLGGNGLTREYGLASLITASRVARIAPVSREMILNYVSHQSLGLPKSY
>NC_021177.1|WP_015610493.1|4715277_4717293_+|acetyl-/propionyl-CoA-carboxylase-subunit-alpha
MIHSLLVANRGEIACRIFRTCRDLGITTVAVYSDADAGALHVREADLAVRLPGSAPADTYLRGDLVVAAALAAGADAVHPGYGFLSENAAFAAAVQDAGLTWVGPPVKAIELMASKTRAKELMGGAGVPLLAPVDPATASEDDLPLLLKAASGGGGRGMRIVRELGALPGELLAAAAEAASAFGDGEVFAEPYVERGRHVEVQVMADAYDTVWALGTRDCSLQRRHQKVIEEAPAPGLDEGLRTRLHDAAVAAARAVGYRGAGTVEFLVSAEGRPYFLEMNTRLQVEHPVTEAVFGVDLVALQLRVAEGEPLDPVLPAASGHAVEARLYAEDPARDWQPQTGALLTLEVPDAPGLRLDTGYTGGDTIGVHYDPMLAKVIAHAPTRTEAVRLLAGALERARIHGPVTNRELLVRSLRHPDFAAARLDTGFYDRHLADLTAPGAGDPATAALAAALAEAVRATASPGPAPTPTRFGAWRNLPSQPQVKRFRSEPDGTEHEIAYRTPRTGTPEPYDAPGVRVLAAAPDRVTLELDGVTRHFELARDRDRLHVDTAGASYTFTALPRFTDPATQTDPGSLLAPMPGTVVRLAEGLAPGARVEAGQPLIWLEAMKMEHRILAPASGTLTALHAAPGHQVEVGALLAVVQEDPEATPVAASAPASAPASASVPEENA
>NC_021177.1|WP_015610492.1|4713581_4715180_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit
MTVLPTGLDTNSPEYAANRAALLEKLTELEAEHAKALAGGGEKYVARHRGRGKLPARERIELLVDPDTPFLELSPLAAWGSDYAVGASLITGIGVVEGVECLITANDPTVRGGASNPWTLKKALRANEIAFANRLPCISLVESGGADLPSQKEIFIPGGALFRDITRLSAAGIPTVAVVFGNSTAGGAYVPGMSDHAVMIRERSKVFLGGPPLVKMATGEESDDESLGGAEMHARTSGLADHFAVDEQDAIRQARRIVARFNWRKAHADPGPAEPPKYDEDELLGIVPGDLKVPFDPREVIARLVDGSDFDAFKPLYGTSLVTGWARLHGYPVGILANAQGVLFSEESQKAAQFIQLANQRDIPLLFLHNTTGYMVGKEYEQGGIIKHGAMMINAVANSKVPHLSVLMGASYGAGHYGMCGRAYDPRFLFAWPSSKSAVMGPQQLAGVLSIVARASSAAKGLPYDDEADAGLRAMVEQQIEAESLPMFLSGRLYDDGVIDPRDTRTVLGMCLSAIHTAPVEGARGGFGVFRM
>NC_021177.1|WP_015610491.1|4711842_4713585_+|DUF1446-domain-containing-protein
MTGTPAPRPLRIGNASGFYGDRFDAVREMLTGGPLDVLTGDYLAELTMLILGRSRLKDPEKGYATTFLRQLEEGLGLAHERGVKIVTNAGGLNPAGLADAIRKLAARVGVPVAVAHVEGDSLPVPDGFLTANAYLGGSGIAACLRAGADIVVTGRVTDAALVTGPAAAHFGWGSDDLDALAGAVVAGHVLECGTQATGGNYAFFSAHDIRRPGFPLAEIHADGSSVITKHDGTGGVVDLSTVTAQLLYETGGARYAGPDVTARLDTVRLTPDGPDRVRIDGVRGEAPPPTLKAGLTRLGGWRNEVVFVLTGLDIEAKARLVEAQFDDALERGGARRPEEVRWELVRTDRDDADTEERASALLRLVVRDRDADAVGRAVSGAAVELALGSYPGFHVTAPPGKGAPYGVFEAVHIPAGDVEHTAVLPDGGREVLEPPSSTRLLEGLDEPPLPDPYPAGPTRRAPLGLVAGARSGDKGGDANVGVWVRDDDAWRWLVHELTVARFRELLPETARLTVVRHVLPNLRALNFTVHGLLGEGVAAQARFDPQAKAVGEWLRSRWLPIPVPLLERDHGHGPSPEVSA
>NC_021177.1|WP_015610490.1|4711039_4711846_+|TIGR03084-family-protein
MSDVAAVVDDLREESDELDVLVGVLEPGRWADRTPAEGWTVAHQIAHLAWTDEVALLAATEPERFGDEVTKALAAPESFVDKAAQALVDAHAPDALLARWRDGRQRLDKVLRDAPAGTRIPWYGPPMSVASMATARLMETWAHGQDIADALGATRAPTARLRHVARIGVRARNYAYAVRGITAPETEFRVELHAPDGELIAYGPEGATQRVTGPLLDFCLLVTQRAHRADLAVTAEGHEADQWLSIAQAFAGPPGPGRLPRAEQDGNR
>NC_021177.1|WP_015610489.1|4710110_4710824_-|NUDIX-domain-containing-protein
MTAEPQLVEPRFDGDRLVLEERRDAGPIRYAFPGTATPPGPPHALSLDEALHARIWPVGTAETVLRAWAEGAGPTGAVQVDDPAAVPPVRVRAGAILIRDGHVLLIRFQDPDEDGPYYEIPGGGVEAGETPEEAAVRELREETGLLGSVGREVARVWKGGRYEHYFLMTAEGRIGPPETLDTYGGTPVWIPVAELPATPLWPRRLSWRIEHWHRTGWPAHPAELADSITDLRAPCTW
>NC_021177.1|WP_043972941.1|4727350_4727749_-|DUF4440-domain-containing-protein
MSEETTDVGTAIAGELQLMDPDVRASRSLAERLLDPEFIEVGASGRRWTYEEMLAALPELSGGDVDGPRHETSSMTGVVLAPGVVHLTYESVLGGNRARRSSLWRRKHGETAWQMYYHQATPVPAGEGQNRS
>NC_021177.1|WP_043974730.1|4727775_4728186_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MQVLDTSALVEFLVGSDTLAERVRSHTAGNRLAAPHVVDLECASVLRGLVRGNKLPEDEATRALDLLGCMQLHRYDHTPLMPRIWELRHNMWPYEASYIALAETLDAELVTADRKLAGAPGLRCTVTDLRGDQGLR
>NC_021177.1|WP_015610501.1|4728188_4728425_-|hypothetical-protein
MATIHIREVPDETVTTLKVRAARSGQSLQAYLLQLLVGEAALLTPEEAAEQARGIAARGRVTADDVSDVLAEMREARS
>NC_021177.1|WP_043972944.1|4728511_4729531_-|hypothetical-protein
MAKPGYGKRSAPNQLPRTRADFALLPARERYVAGFVDHLPEGAAMSVKQLAKQLPLYGQQAISSALTALSVAGHLRRVRCALGAGDETRWVFRTFWSRTAHDNEWWQAYLTAENTTQADSSAPDTPAPDTAPPSWVPDEEPPPPASEEPGTEQGPEPTPLPHQRTPDQAPDTQPVPPAPAPHPSEAGPSPAYLALARLGHEDHRLPLSADDCQELEAQAAEWLARGVSVDYLITALTAGLPARVDTPLGFVRRRLTDKIPPRIPATPSVPSGTPAPPHRFLLECTDCGRPGQPEALPDGLCRPCRTARRPATDETPAPSTEAAQIKARMTDLRGLLRTV
>NC_021177.1|WP_015610503.1|4729966_4730965_-|GNAT-family-N-acetyltransferase
MDVNRGGGLGAPGRLPGYLFRPYRGDEDHLAMAAVRLGCAGRDEVDARSVVEGIPTAAEIAEASAELDNPSENQVLVEHNGDIVGYATIRWWQERDGTWLYLHRGYLLPDHRGAGIGSDMLSWAESRIRHLVQHHGTARTAVFGANAMASETDSTQLLLETGHRRVFSLVELELADLRSLPEYDGRLPAGVTVGAVDPTSYHAAWKTVVDSYAQAAFTEKWTFERFLATAVPTCWRAAWHEDQLAGVALCSLRRHDPTVGEVEELSVRAESRRLGLGRALLLDGLRSLREHGAESARLYTGTANPHRSYDLYESVGFRRQNEYVRYRKPIGI
>NC_021177.1|WP_015610504.1|4731164_4731497_-|hypothetical-protein
MAKTTRSLPQSLRHYLVNPLALGYLGIVLGVCLWVAADALFASSSGDASFAGVWAVLATAPTSLLVPFEGPVALIGIPIGAIVQAFALGAMYRYATERRAHGTANGVSSA
>NC_021177.1|WP_015610505.1|4731637_4733029_-|cytochrome-P450
MIEDGGGARGCPASREEPRVAHSRTLRFWLDPANIAVRLGQAGPVVRTKAGPAVAFQVNDPSLIRKVGCGEDIFQAWSADPCLRDFTGDGFAGAEGQAHRDRRALMKPALAAPRLTALGPSVRDSTEGLLAGLPADRPVDVPVEMSRLVAGLVIETVLNSGISPDTLAALARARSVLSAGVFWKYALSPWPWVPAPRGRAFRRALGTLNEATQEVYERHQPDGDGNDVVSLLKRSSDNRPDAALHDLRALLFAGIEATASTLAWACYELGRHPDHQAAIRAEADAVLGADAPADAVRPEQMPRTAGFIREVTRLHGIPFLVRRPRHATYVGEQPVPAGALVTLPMGALRRDPARYARPEEFDPLRWSPEARPQLSPAALLPYGLGPRYCPGAAASEILTPVALASLVRSRTLRTTTPDRTVRVSLELTPMPKGLTMLAAPREPHSPLVPGPTSSEEADPARRP
>NC_021177.1|WP_015610506.1|4733507_4734122_+|SMI1/KNR4-family-protein
MTRMHETTKAADSGVTDTLTTPEEWRGFLGRYDERYMKNEASDQELADLLDEDEWDLLEEEGRLEQWLGEAPSSDEELAAAEERLGVRFTPSLRGFFLASNGWKRVKGWVDLVRPCGEVAWMRDSDAGSSVIRIYGEDPANDDYVQLFRRSIEVAGGEDFWLLDPTSAGPDGEWSAYLFAPKYGDLQEFSSFSALFHDGYEDMD
>NC_021177.1|WP_015610508.1|4734303_4734993_+|DUF4232-domain-containing-protein
MFGNRNRRKALLVSAALVGSALLMTACQDTDGSGAVDTGAAQSGSPSAGSEPSASADGPAATPSAGAGAPDADPSASASGGREGSGADTGSGEREQVGQVCGANDLSWSTRSESQAGGYILVMAKAKSGITCVLPAALPTIAFGSDGTEAGPAEQSVGKAITLSGGTVAYAGVNPKTTNTDWGKELDSIIVAIGNDDANPVSLKVGTINVDKPVVTNWHTAPKDAVPFS
>NC_021177.1|WP_043972946.1|4735061_4735613_-|VOC-family-protein
MTAPRPSLTLSSTVLEAPDAAELADFYRRLLGWEPVQEEPDWVKLLPPGGGSGLGFQTSKPYVPPVWPASLTSQGDQLMMLHLDFEVTDLEAGVAHAVAEGATPAEFQPQRDVRVLFDPVGHPFCLFVRDHVLGETPAISPEWVAEQARDIRTQNPVAAEAVTPDRREAAGTAEPGSGDAVPA

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Crispr_ID: NC_021177_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_15

4754806-4754915

Orphan

Consensus_repeat	Method
CCGGGCGGGGACGCCGACGCCACGCAGTACAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_15

>merge|NC_021177|15|4754806-4754915|CRISPRCasFinder
CCGGGCGGGGACGCCGACGCCACGCAGTACATCGCGCCGGTCCCGGGCGGGGCCGGTCTCGGCGGTCTGCCGCCGCAGCCGGGCGGGGACGCGGACGCCACGCAGTACAT

>NC_021177|15|15|4754806-4754915|CRISPRCasFinder
CCGGGCGGGGACGCCGACGCCACGCAGTACAT	CGCGCCGGTCCCGGGCGGGGCCGGTCTCGGCGGTCTGCCGCCGCAG
CCGGGCGGGGACGCGGACGCCACGCAGTACAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015610531.1\|4758758_4760228_-\|immediate-early-protein	unknown	unknown	gnl\|CDD\|371689
NC_021177.1\|WP_106960133.1\|4750783_4751542_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_021177.1\|WP_015610520.1\|4746300_4746993_+\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NC_021177.1\|WP_015610529.1\|4757368_4757815_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610536.1\|4763992_4765192_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NC_021177.1\|WP_015610528.1\|4755913_4757194_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380564
NC_021177.1\|WP_015610535.1\|4762244_4763822_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|171961
NC_021177.1\|WP_015610523.1\|4749146_4750787_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610532.1\|4760224_4760818_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|182015
NC_021177.1\|WP_015610518.1\|4744163_4745330_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|273593
NC_021177.1\|WP_015610534.1\|4761658_4762186_+\|EF-hand-domain-containing-protein	unknown	unknown	gnl\|CDD\|372618
NC_021177.1\|WP_015610526.1\|4752679_4754062_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610530.1\|4757843_4758743_+\|formyltetrahydrofolate-deformylase	unknown	unknown	gnl\|CDD\|235676
NC_021177.1\|WP_015610537.1\|4765203_4766358_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NC_021177.1\|WP_015610519.1\|4745345_4746101_-\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|179510
NC_021177.1\|WP_015610525.1\|4751711_4752398_-\|bifunctional-DNA-primase/polymerase	unknown	unknown	gnl\|CDD\|378140
NC_021177.1\|WP_015610517.1\|4743447_4744167_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_021177.1\|WP_015610521.1\|4747704_4748613_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_021177.1\|WP_015610533.1\|4761147_4761522_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_021177.1\|WP_015610522.1\|4748682_4749147_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015610531.1\|4758758_4760228_-\|immediate-early-protein	gnl\|CDD\|371689	pfam11716, MDMPI_N, Mycothiol maleylpyruvate isomerase N-terminal domain.	0.000687108
NC_021177.1\|WP_106960133.1\|4750783_4751542_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.28211e-88
NC_021177.1\|WP_015610520.1\|4746300_4746993_+\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	9.47849e-46
NC_021177.1\|WP_015610536.1\|4763992_4765192_+\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	2.75854e-36
NC_021177.1\|WP_015610528.1\|4755913_4757194_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380564	cd06341, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.	2.60517e-35
NC_021177.1\|WP_015610535.1\|4762244_4763822_-\|AMP-binding-protein	gnl\|CDD\|171961	PRK13295, PRK13295, cyclohexanecarboxylate-CoA ligase; Reviewed.	2.66551e-118
NC_021177.1\|WP_015610532.1\|4760224_4760818_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|182015	PRK09646, PRK09646, ECF RNA polymerase sigma factor SigK.	2.18507e-18
NC_021177.1\|WP_015610534.1\|4761658_4762186_+\|EF-hand-domain-containing-protein	gnl\|CDD\|372618	pfam13499, EF-hand_7, EF-hand domain pair.	7.04389e-05
NC_021177.1\|WP_015610519.1\|4745345_4746101_-\|SIS-domain-containing-protein	gnl\|CDD\|179510	PRK02947, PRK02947, sugar isomerase domain-containing protein.	1.50376e-105
NC_021177.1\|WP_015610530.1\|4757843_4758743_+\|formyltetrahydrofolate-deformylase	gnl\|CDD\|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	0
NC_021177.1\|WP_015610537.1\|4765203_4766358_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	3.49651e-166
NC_021177.1\|WP_015610518.1\|4744163_4745330_+\|HAMP-domain-containing-protein	gnl\|CDD\|273593	TIGR01386, Probable_sensor_protein_PcoS, heavy metal sensor kinase. Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.	5.59768e-51
NC_021177.1\|WP_015610525.1\|4751711_4752398_-\|bifunctional-DNA-primase/polymerase	gnl\|CDD\|378140	pfam09250, Prim-Pol, Bifunctional DNA primase/polymerase, N-terminal. Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities.	3.30725e-25
NC_021177.1\|WP_015610517.1\|4743447_4744167_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.3836e-66
NC_021177.1\|WP_015610521.1\|4747704_4748613_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.72738e-28
NC_021177.1\|WP_015610533.1\|4761147_4761522_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.91462e-24

>NC_021177.1|WP_015610526.1|4752679_4754062_+|hypothetical-protein
MAARPLVARQPNERLQTLIQEAACSNAGLARRVNMVGAERGLDLRYDKTSVARWLRGQQPRGRAPGIIAEALGRKLGRTVTIDEIGMANGKNLASGVGLQYAPTVAGAVEQVCELWRSDVGRRDLLTGSAVAASALVEPSRDWLISGRDPQVERVAGARVGMADVAAVQAMTTALTDLDHRFGSGHVRPVLVHYLNSVVSGLLSGAYREQVGRELFAAVARLTELGGYMAVDTGQPGLAQRYYIQALRLAQAAGDRAYGGYVLAASMSHLAAQLGNPREIAQLARAAQEGARGQVTPRAQAMFYAAEARGHALLGDARTCQVVMGRAVAALEQADPETGDDPDWIAHFDHGYLADELAHCHRDLNQAADAARRAKEALAALPETRARRRGIGLVLLASAQVQQREVERACHTGTRAMELLGTVRSSRGAEYLDDLHQRLAPYGQEPAVREFGERLELQAA
>NC_021177.1|WP_015610525.1|4751711_4752398_-|bifunctional-DNA-primase/polymerase
MLDVEEPMGVTEAAQVPQQRGEQLLDAAVRYAEERHWDVFPGTWLEAVEGRELCSCGEAACPLPGAHADRPDWAGQATGSGAAARRMWSKQPRASVLLPTGRTFDALDVPESAGFLALARMERMDLTLGPVTCTPDRRMLFFVLPGAAAKASELVRTLGWNAEAIDLVGRGEGHYLAAPPTRVGGRGAVQWARKPTHANRWLPDVDELISPLAYACAREAADARARVS
>NC_021177.1|WP_106960133.1|4750783_4751542_-|ABC-transporter-ATP-binding-protein
MRVQGLWKRFGEQVAVSGIDLELPAGKFIGLVGPNGAGKTTTLSMVTGLLRPDMGKIEVAGHDVWTDPVAVKSRIGVLPEGLRLFERLSGRELLAYNGRLRGLPGDEVDKRAAQLLDVLDLAGSQHKLVVDYSTGMRKKIGLAAALLHNPEVLFLDEPFEGVDPVSAQTIRGVLERYTRSGATVVFSSHVMELVESLCDWVAVMAAGRIKAQGTLAEVRGDAPSLQNAFLELVGAGGRDTTGDSLDWLGGAR
>NC_021177.1|WP_015610523.1|4749146_4750787_-|hypothetical-protein
MSVLDAPVTAAAPAAPTTGLTPIFVRLKLTLLRNGLRQSTGRRTAFIVSLVLTLLLAAGQVLGLVLLRGNAQAGTVVVLLTAVVALGWAVLPLFFPSGDDTLDPTRLVMLPLRPEPLVRALLVSSMIGIGPLFTLCLVVGSVLALAHGFAGIVFAVLAVPLTMLLCVALSRAVTTANVRLLNSRKGRDLAVLSGLVIAVGIQFVNFGAQRLGEAGGLSSLEPAGNVARWLPGASAIASVDAASDGSYGVAVAQLLITGAALAALVWLWQRGLVKLMTTPDGSTLAAAAPDRKESGRTGGLSGLLPEGRTGTVVQRSLRYVARDPKTKAAWVTSLALGAIVPLINAVQGTGSVYLACFAAGMLGMLMYNQFGQDTSAFWMVALTISSTRDAYVELRARACALLLITLPYTLLVCAVTAAVLGRWQSLPGALGLSFALLGAMMATGAVASALFPYSIPQDGAFKNAAPGQGGLAWISILLGMLAALLLAAPVIVLTVWLHLTDRQEALWVVIPVGVAYGTFIGWAGLRIAAPRTANRLPEILTAVSKG
>NC_021177.1|WP_015610522.1|4748682_4749147_-|hypothetical-protein
MPLLHRRIAPALVVAQLLYLALMELAFTFLSPGNPEPDATGSARNALLGYGAVMVAVAAVMAGGALMLASSRASAAVPRPVRSVLLVLLGLLELGIAAAFLHSAATGSLGPDTVIAGVAVVVSGCVAAGCVPGPAAAPPTQHTPHGRPTARTTG
>NC_021177.1|WP_015610521.1|4747704_4748613_+|alpha/beta-hydrolase
MVRRIDVTGADGVRLAAWEFADPPKERAGTDGGGADRAPGVLLLHGLMGRASHWAPTARWLAERYRAVGLDQRGHGRSDKPAEGPYTRDAYVADAEAAIEQLGLGPVTVVGHAMGALTGWQLAAKRPDLVRAVVICDMRASALGAASQREWSDWFDSWPLPFATLADVRKWFGEDDPWVERPNPSRGEFYAEVMAECEDGWRPVFSRGQMLRSRATWVFDAHWEELTQVRCPTLVLRGLDGELGRAEAQEMVRVLPRGQYAEVADAGHLVHYDQPEGWRAAVEPFLEQLAEDTRGDREPVAP
>NC_021177.1|WP_015610520.1|4746300_4746993_+|metal-dependent-transcriptional-regulator
MSGLIDTTEMYLRTILELEEEGVVPMRARIAERLDQSGPTVSQTVARMERDGLVQVAGDRHLELTEEGRRLATRVMRKHRLAECLLVDVIGLEWEQVHAEACRWEHVMSEAVERRVLELLRHPTESPYGNPIPGLEELGEKAEADPFLDDSMVSLAELDPGSEGKTVVVRRIGEPIQTDAQLMYTLRRAGVQPGSVVSVTESPGGVLVGSSGEAAELDAEVASHVFVAKR
>NC_021177.1|WP_015610519.1|4745345_4746101_-|SIS-domain-containing-protein
MSDSKLAGQFFDAAIGLLQRVRDEEAGSIAAAGAAIADTVEAGGRLFAYGAGHSSLAAQDVVYRAGGLALMNLLTVPGTTGVDVMPATLGSALERVDGLASAVLDSSPAAAGDVLVIISLSGRNALPVEMAQNARALGLKVIGVTSVAYAENTRSRHTSGGFLRDHCDIVLDSKIAIGDAELTAPGIEAPFAPASTVVTSAIMQSMMAAAAEQLVARGIEPPLLRSGNVDGGHDWNGRVMTEYRERIFYRH
>NC_021177.1|WP_015610518.1|4744163_4745330_+|HAMP-domain-containing-protein
MNSERTRLTALYGGLLVLAGVLLMGLVYVLVSEGLYSSVMTAVVPTVPASELGESAAPALPSSDWAQTTVIQPGQYAVARKVSTAAGDAALNQLLTVSGISLAVYSALSVALAWWMAGRVLRPVGVITARARRLSGSNLHERIALQAPPGELKELADTFDGMLDRIEQLVAARQRFAANAAHELRTPLAVQRAAAEIGLADDPTPEKVAWIRDKLIDTADNSEQLIEGLLLLAVSDEGLRRRERVDLDATTTTVTEALAAEAEERAVTVDVEARPVSVQGDPVLLDHLVHNLVANALRHNHPGGTVRVRVGPGGLEVANTGPVVDPAAVPLLFEPFRRAQARRHAPGEGAGLGLSIVASVTRAHGGDVGATANPGGGLTARVTLPTCA
>NC_021177.1|WP_015610517.1|4743447_4744167_+|response-regulator-transcription-factor
MRVLVVEDEEFLAEMIAEGLRRDAVAVDIAPDGPSALEKLRFGAYDVMILDRDLPGLHGDEVCRRVVGARLLTRILMLTASGTVRDRVAGLGLGADDYLTKPFAYDELLARVLALGRRSRPALPPVLERAGLTLDTARRQVCRDGRYLSLSRKEFAVLETLLRAEGAVVSGDDLIEEVWEEDTSYRTNAVRVTLSKLRTKLGAPPVIETVPGAGYRIGNGPAAGTGNGPAPLTGPEDTR
>NC_021177.1|WP_015610528.1|4755913_4757194_-|ABC-transporter-substrate-binding-protein
MTGRRRTAFPRPFQFVIGTAAAGALLLSGCGVLPGGPGGSGEPVTVMTWAPDQVDDADALSMPGVPAMARTYARWINEQGGIDGRELRVITCDERDTAAGAERCARQAVDRKVAAVVGSYSRHGQSSIPVLESGGIPYIGGYGASDEEFRSYLSYPVNGGQSALLAGHGRQLAGGCERVALVRPDSLGGARMPQLLNTGLLAAQRPESTDITAPENATSYEEQATKALKRRKGGSCVAAVLGAGTETFFDSFRRLEPEGERVRISSVLGSVSQPLIDRTGGRKSPFEGAYITGWYPDAGDARWNGMREVIRKYAFGDNRIDPDDTGVQTTWIAYTALRAVVEAIGDDTVTANKVTSSLNRGTEVDTGGLTPVLRWRFKDLLGTSPYPRIVNADVTFQVVREGRLIAQKKGFVDVAEALSDARRTVG
>NC_021177.1|WP_015610529.1|4757368_4757815_+|hypothetical-protein
MGVMPLTDMPWWRWRTNVRSALHMLSDSVFHHECWLAGREGYGDVTDAVYRLVEDTWLDNWSAEKYVGTIFRDSAEATAVDTAALRVLRIMHQVGADAPVSAYLEHHGWPEAVRAAREAHVMLATNDAEDPDIPPRSLDVIRIMTRAA
>NC_021177.1|WP_015610530.1|4757843_4758743_+|formyltetrahydrofolate-deformylase
MTAPQPTAPPAASDTALPEQYVLTLSCPDKQGIVHAVSSYLFMTGCNIEDSQQFGDHDTGLFFMRVHFSAEATVTVDKLRASFAAIGEAFRMEWQIHRPAERMRIVLMVSKFGHCLNDLLFRSRTGALPVEIAAVVSNHTDFAELVASYGVPFRHLPVTKDNKAEAEAQLLELVREEDVELVVLARYMQVLSDDLCKQLSGRIINIHHSFLPSFKGAKPYHQAHARGVKLIGATAHYVTADLDEGPIIEQEVERVGHDVTPDQLVAIGRDVECQALARAVKWHAERRILLNGRRTVIFN
>NC_021177.1|WP_015610531.1|4758758_4760228_-|immediate-early-protein
MNGGGREGDRRDDEVRGARRIPGPRGAVDDLDLETVERPVLPPPGGSTPDEAVPEQGAPEGDGDVRDAVPEAGAADEPDVVDPDAVDAVDEPYAVDGPDAVDEPEPAMTSATSATPATSAATPVLSHQVLKALLGAWALSACSAEETAAVEDHLTVCAPCADEALRLRDAVGLLHTDGSLDLDPTLRTRVMDGCLGRRPARIPVPDWATPYDAETARLDALLRDIGDSEWHAPVRLQWFEDERPATRRTTVAGVIGHLMAVDGLVSAALGLDDPLGRVEVPLSPARRTETYWAATRPPATRAVREPWRDLTHELIRTASLAGRNVAERSVSYGDFALPLQDALLDRAFECWVHGTDIAEAVDYPYKPPSAAHLHRMIDLAARLLPAALAGRRSAGLAGPAKELVAPGEPGRSVHLEVEGHGGGDWYIPLDSPAAVGSPRRAVAQVALDGVEFCQLVAGHISPVEAAAGQEGDREAIRDVLFASASLSRL
>NC_021177.1|WP_015610532.1|4760224_4760818_-|sigma-70-family-RNA-polymerase-sigma-factor
MAKDAPPRWDRRMQQRLARGEAAALGELYDRFASLVHSQAHRMLDDEDAADLVTREVFAQVWEDPEAYDPKQGSMRSWVARLTHRQSVRRLRREAALSYAQEHGEGAVPDPEELERRVRSATAAARADYIVSSMPASLRQALELAYIQRRDYRQTAADLGVTEDEARRRLRLGLQLLSTANTRPREGCSPPGYGRAK
>NC_021177.1|WP_015610533.1|4761147_4761522_+|STAS-domain-containing-protein
MTLKVDETEQGDWTVLRIRGELDLVSSPVVRQSVHDAVAEGQHDVVLDLSEVFFCDSSGVGVLIASRRLMKSCGGRLRLILPARGAEDGSHVNKVLGALGVRRLFDVYPDTGSAVDGACEPLTA
>NC_021177.1|WP_015610534.1|4761658_4762186_+|EF-hand-domain-containing-protein
MDSAEYERKIAHRFAAFDQDGNGTIDRADFNAAAARLLTEFGTTARCDKGQALYTGAEAFWQGMAGIADVDGDQRVTREEFVGGAVKRLRDNPERFAEIARPFLRAAIAVADSENGGGRASVASVERALKVLGASSEIAGIAAQSLDTDRDGLIAESDVVAALAVYFTVIEPDAT
>NC_021177.1|WP_015610535.1|4762244_4763822_-|AMP-binding-protein
MTAVNDVTATAHALGDSRTFWELIERRAALTPDRPVLLQGDRALTFGGLRDRAERVAAGLYGMGVRAGSVVAWQLPTRLETALLSFALSRLGAVQTPVIPFYRDREVRFALRESGAAFFAVPGVWRGFDHTAMAERIAAELPDQPQVFEAYEDLPDGDPAILPPPPAPPSGEEVRWIYWTSGTTSDPKGVLHTDRSLIAGGSCLAHALKLSADDVGSMAFPYAHVAGPDYTVMLLLYGFPAVMFEQFALPDALAEYRLHGVTVAGGSTAFYAMFLAEQRKEPGTPLIPSLRLLAGGGAPKPPEVYHAVVREMGVRLTHGYGMTEVPMITMGAPDDTTENLALTEGRPPAGMEIRITDEQGKPLPYGVEGEVRLRGEAVCRGYLDPGASAAAFDAEGFLITGDLGRLQESGHLTLTGRLKDIIIRKGENISAKEIEDLLHTHPAVADAAVIGLPDTERGERVCAVIEQPPGAPPLTLAGMSAHLRGAGLSVHKVPEQLEVLDSLPRNETLRKVLKYQLRERFGTGG
>NC_021177.1|WP_015610536.1|4763992_4765192_+|amidohydrolase
MTDTELPRIVSVDDHVIEPAHLFSTWLPAKYRERGPQPLTAGIGELAYTGGKYVITMDPDGPPTDWWIYEDLKFPYKRNIAAVGFDRDDMTLEGITRAEMRPGCWDPAERLKDMDLNHVEASLCFPTFPRFCGQTFAEAHDKEVALACVRAYNDWMVEEWCGDSGGRLIPLCIIPLWDIDLAVAEIKRNAARGVRAVTFSEIPTYLGLPSIHTGYWDPFFAVCQETGTVVNMHIGSSSQMPAASPDAPPAVQASLSFNNAMASMMDFLFSGVLVKFPTLKLAYSEGQMGWIPYALERADDVWEEHRAWGGVRDLIPEPPSTYYYRQMFCCFFRDKHGIASLDVVGRDNATFETDYPHVDSTFPHTREVALDHVKGLDEETVYKLMRGNAIRMLGLDLDK
>NC_021177.1|WP_015610537.1|4765203_4766358_+|acyl-CoA-dehydrogenase
MDLTYTEAEEEFRRRLGEWLAAVLPGLPPKPSPDDWPARRAYDTTWQRMLYDAGYAGLHWPEDAGGRGATPTQHLIFLEETEKAGAPYVGANFVGLLHAGPTVAAEGTAEQRARWLPPVLRGDEVWCQGFSEPDAGSDLAALRTRAVRDGDDYVVSGSKIWTSHAEVADWCELLVRTDPDAPKHRGISWLAMPMDAPGITVRPLRTLAGSTEFAEVFLDEVRVPVRNRVGAENDGWRVTMVTLSFERGTAFVGEVVACRRTLDALAAEARRNGKWDDAVLRRRLGRLNAEFRALWRLTQWNVAESERTGGVPGIGGSVFKLRYSRTRQELYEAAAEVLGADAFDLDREWALDRLSSLSYTIAAGTSQIQRNIVAERILGLPKGR

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Click the colored protein region to show detailed information

Crispr_ID: NC_021177_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_16

4808896-4809004

Orphan

Consensus_repeat	Method
CCCCAGCCCGTCCGGCGTTTGAGGACGGAACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_16

>merge|NC_021177|16|4808896-4809004|CRISPRCasFinder
CCCCAGCCCGTCCGGCGTTTGAGGACGGAACCGTTGACGGGGTGGCCGTCAGCTCTGAGGGGCCGGAGCCCCGGAGACCCCAGCCCGTCCGGCGTTTGAGGACGGAACC

>NC_021177|16|16|4808896-4809004|CRISPRCasFinder
CCCCAGCCCGTCCGGCGTTTGAGGACGGAACC	GTTGACGGGGTGGCCGTCAGCTCTGAGGGGCCGGAGCCCCGGAGA
CCCCAGCCCGTCCGGCGTTTGAGGACGGAACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_032760062.1\|4806482_4808891_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|270916
NC_021177.1\|WP_015610583.1\|4810529_4811318_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NC_021177.1\|WP_015610585.1\|4811786_4812935_-\|lipid-transfer-protein	unknown	unknown	gnl\|CDD\|181147
NC_021177.1\|WP_015610576.1\|4802481_4803684_+\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NC_021177.1\|WP_015610579.1\|4805400_4806210_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NC_021177.1\|WP_043972972.1\|4809020_4809734_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236251
NC_021177.1\|WP_015610573.1\|4799370_4800279_-\|zinc-metalloprotease-HtpX	unknown	unknown	gnl\|CDD\|179418
NC_021177.1\|WP_015610591.1\|4816175_4819142_-\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|276938
NC_021177.1\|WP_015610590.1\|4815763_4815943_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610588.1\|4814900_4815299_-\|twitching-motility-protein-PilT	unknown	unknown	gnl\|CDD\|350222
NC_021177.1\|WP_015610572.1\|4798754_4799348_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610589.1\|4815295_4815574_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610575.1\|4801142_4802318_-\|propanoyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|180434
NC_021177.1\|WP_015610571.1\|4798325_4798754_+\|Zn-ribbon-domain-containing-OB-fold-protein	unknown	unknown	gnl\|CDD\|224462
NC_021177.1\|WP_015610578.1\|4804319_4804967_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_021177.1\|WP_015610574.1\|4800361_4801042_-\|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl\|CDD\|273138
NC_021177.1\|WP_015610582.1\|4809965_4810496_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610584.1\|4811321_4811774_-\|DUF35-domain-containing-protein	unknown	unknown	gnl\|CDD\|224462
NC_021177.1\|WP_043972976.1\|4813073_4814630_+\|fatty-acid--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|236072
NC_021177.1\|WP_015610577.1\|4803683_4804169_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|211538

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_032760062.1\|4806482_4808891_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.29254e-75
NC_021177.1\|WP_015610585.1\|4811786_4812935_-\|lipid-transfer-protein	gnl\|CDD\|181147	PRK07855, PRK07855, lipid-transfer protein; Provisional.	0
NC_021177.1\|WP_015610576.1\|4802481_4803684_+\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	1.96176e-42
NC_021177.1\|WP_015610579.1\|4805400_4806210_+\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	2.33639e-27
NC_021177.1\|WP_043972972.1\|4809020_4809734_-\|hypothetical-protein	gnl\|CDD\|236251	PRK08375, PRK08375, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0.00326094
NC_021177.1\|WP_015610573.1\|4799370_4800279_-\|zinc-metalloprotease-HtpX	gnl\|CDD\|179418	PRK02391, PRK02391, heat shock protein HtpX; Provisional.	1.84505e-172
NC_021177.1\|WP_015610591.1\|4816175_4819142_-\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	3.69679e-37
NC_021177.1\|WP_015610588.1\|4814900_4815299_-\|twitching-motility-protein-PilT	gnl\|CDD\|350222	cd09874, PIN_MT3492-like, VapC-like PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis CDC1551, hypothetical protein MT3492, and similar bacterial and archaeal proteins are included in this subfamily. They are PIN domain homologs of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	0.000720633
NC_021177.1\|WP_015610574.1\|4800361_4801042_-\|pyridoxamine-5'-phosphate-oxidase	gnl\|CDD\|273138	TIGR00558, Pyridoxine/pyridoxamine_5'-phosphate_oxidase, pyridoxamine-phosphate oxidase. This model is similar to Pyridox_oxidase from Pfam but is designed to find only true pyridoxamine-phosphate oxidase and to ignore the related protein PhzG involved in phenazine biosynthesis. This protein from E. coli was characterized as a homodimer with two FMN per dimer. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine].	2.31118e-58
NC_021177.1\|WP_015610575.1\|4801142_4802318_-\|propanoyl-CoA-C-acyltransferase	gnl\|CDD\|180434	PRK06158, PRK06158, thiolase; Provisional.	8.96605e-134
NC_021177.1\|WP_015610571.1\|4798325_4798754_+\|Zn-ribbon-domain-containing-OB-fold-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	2.19896e-25
NC_021177.1\|WP_015610578.1\|4804319_4804967_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.11966e-10
NC_021177.1\|WP_015610583.1\|4810529_4811318_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	5.9381e-38
NC_021177.1\|WP_015610584.1\|4811321_4811774_-\|DUF35-domain-containing-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	1.06983e-22
NC_021177.1\|WP_043972976.1\|4813073_4814630_+\|fatty-acid--CoA-ligase-family-protein	gnl\|CDD\|236072	PRK07656, PRK07656, long-chain-fatty-acid--CoA ligase; Validated.	0
NC_021177.1\|WP_015610577.1\|4803683_4804169_+\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|211538	TIGR00026, Hypothetical_protein_Rv1261c/MT1299/Mb1292c., deazaflavin-dependent oxidoreductase, nitroreductase family. This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity].	2.66838e-19

>NC_021177.1|WP_032760062.1|4806482_4808891_+|PQQ-binding-like-beta-propeller-repeat-protein
MEQLTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGPMPTQAVRWLAAGIAEALQSIHGAGLVHRDMKPSNVLVVEDGPRVIDFGIASGVSNTRLTMTNVAVGTPAYMSPEQARDSRSVTGASDIFSLGSTLVFAATGHAPFHGANPVETVFMLLREGPDTEGLPDDLRPLIESCMQMDPTQRPSPADLQAQLAPHLFASGSDDSGTASAWLPSLATAMIERRRGGGRTAPPAAPSAPPPRPPQPPRAPDRAPDRGPDWRSGGDLRSPSPLSSPAPVSSPAPSPDGGPVHLPGAKAPIGPGPRAGEGRGAAAAHPAAATGWVRPPAGLNGSDPASTAPVPAPGPAPDASPAAPDRWRPWRFRMSNDVWGTPVVSGDLLYVTSFEIHALDVGNGRRQFKTRDVAWAMAVEGGRIHASDGPSLYALDAASGTEQWRVRTDAWVYALKADRGTVLTATRGGGVQGWEASNGDKLWEITGVQSDFETVEAAPVIHDGTVYVWQDARLRALDARTGLERWSYPIGDAASCGGVPVRVTPAPDGYVYVAAGTRVLAVENVSGRVRWHFESPAVFLSPPAFAQGPAVTGGGVYLADYLGTVYALDATTGKDRWRIATEARASVEPVLVAVGNVHVGSGSALYTLDAVTGTPKWRFAAGGDVVGSPVVADGRVHFGSADHVLYTLDAAGGQLRWKLATGGEITGSPVAQAGVVYACSKDRCVYALDALKGTGTGNRART
>NC_021177.1|WP_015610579.1|4805400_4806210_+|VOC-family-protein
MAAFAHSAPCWADVQLSDLEAGKRFYGGLFGWTFRAGDGMPFADALSGGRLVAALAAKKDGRMPTAWGVYFATDDIRATVAAIREHGGQIITDPVRAGQAGIVAQAADPGGAVFGLWQPEEREGFEKQNEPGSFCWTEVHTRRPEEVDPFYEKVFGFRGTDLDEAGNDVSDDAEALVDFRMWSPEGAEPGPDSAVGGRSVITDAFPAEMPSYFLTYFAVADCDAAAELAVQLGGRVSAPPFDIPYGRMAVLHDDQGALFAVLQPSELLP
>NC_021177.1|WP_015610578.1|4804319_4804967_-|TetR/AcrR-family-transcriptional-regulator
MTGQVRTVDGRVAGRRGQATRQKLLDCLSEMLSSSPYRDVKVIDVARKAGTSPATFYQYFPDVEGAVLEIAEEVAKEGAGLTELVAGRPWVGKAGWQTAEELVEGFLDFWRRNDAILRVIDLGAAEGDKRFYKIRMKILNSVTNSLTDSVKELQAKGRVDKDISPAAMAGSLVAMLAAVASHQKGFTTWGVKQAELRPNLALLVHLGITGKKPTK
>NC_021177.1|WP_015610577.1|4803683_4804169_+|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MAGTRAARLIQKVSSTRAFAKFAPHVVPVMDRTVHRLTRGKVLPSARMLPGLVLTVPGARSGQPRVTPLACMPEGEAESTWILVGSNFGRTGHPAWTANLLARPEEAVISWRGRDIPVRARLLEGAEREEVWRVALTFWPPYAAYQARVERQIRLFRLERR
>NC_021177.1|WP_015610576.1|4802481_4803684_+|acyl-CoA/acyl-ACP-dehydrogenase
MDAAFTAEQDEIRRTLRDLLTKHSGPGEVRAAVRTAEGHDPALWHRLAQELGLPGLAIAEEYGGAGCTATELALACEETGRALLPSPLLATAVLAAPLIAALGTPEQRAELLPRIADGTLTATLAAPGGSMATALGLTADNRAAAWAGGGRAGGIQARPDGGGGWRLYGEADRVLDGHSAGLLLVAAHTGGYPRSRTLLFLVSAEAEGLARTRLTSMDETRPLARIELRDAAARLLGADDGTDVCGALADTGSRAAAVLAAEAVGAAAGALERTVAYVKEREQFGRAIGSFQAVKHRLADLYVRVEAARSAAYYTAWDAAAGPLALAQALEAARIVAGEAVQLHGGIGFTWEHEAHLYVKRAAADELLFGPVHRLRDHAAGRAGLFGAVTADGPVHGVAV
>NC_021177.1|WP_015610575.1|4801142_4802318_-|propanoyl-CoA-C-acyltransferase
MPASRLSRRVAVVGISLADCGRVDDATPYALHAQAARRALADSGLDRSVIDGFASAGLGTLAPVEVAEYLGLRPTWVDSTAVGGATWEVMAAHAADAIAAGRARAVLLVYGSTARADIKAGRRTSNLSFGARGPLQFEVPYGHSLIAKYAMAARRHMHEYGTTLEQLAEVAVTARANAAANPEAMFRDPITVDDVLSGPMIADPFTKLHCCIRSDGGCAVLLAAEEYVPDTAKAPVWILGTGEHASHSTMSEWEDFTVSPAAVSGRLAFERAGVRPCDIDLAEIYDAFTYMTLVTLEDLGFCAKGEGGAFVEKGRTGLRGELPVNTDGGGLSACHPGMRGLFLLVEAVRQLRGEAGARQVHKAGGRLPELAVASGTGGWFCSSGTVVLGRG
>NC_021177.1|WP_015610574.1|4800361_4801042_-|pyridoxamine-5'-phosphate-oxidase
MSEAAAPTPRPFSALLHAQRVWDSELPSFDPATAPPSPLPLFHGWFADAVAAGQQEPHAMTLATADAEGLPDVRTLLLHDADERGFHFASHATSAKGHQLAARPYAALGFYWPALGRQVRVRGPVVRCTPAESHADLHARSTGALAAALTGAQSAVVESVAALHRAADAAWERARAEPDAEAPTWTRYVVEPAEAEFFQGDARRRHIRLRYRRTDDGTWTRELLWP
>NC_021177.1|WP_015610573.1|4799370_4800279_-|zinc-metalloprotease-HtpX
MARARSRYAPDRGLTGRMVTTMFLIGLLYVVFVGVLLAALRGSWPIILIITGGLFIAQFWFSDRIAAYGMGAREVTPEQAPELHGTIDRICALADMPKPKVAIAESDVPNAFATGRSEKTALVCATTGLLRRLEPEELEGVLAHEMSHVAHRDVAVMTIASFLGVLAGIITRIALWGGFARSRPGNDPAGILLLLIPLISAVVYAISFLLTRLLSRYRELSADRAAALLTGRPSALASALTKVSGQMARIPTEDLRKAEPYNAFYFMPAFSAKESLGRLFSSHPTLEQRLDQLSRISTDLSR
>NC_021177.1|WP_015610572.1|4798754_4799348_-|hypothetical-protein
MGLLDAILGRSKPVRPDLDQLFAVPSAALTLQAATGFTPTGLGSVCFAGVEGGGFARLQEDVRELLDADTERGGIPVEFSRDAYGYTWLLASHPADDTAGLVNDLHAVNTLLQDGGFGPHLLCSLIGFRDPQAAEGRSLALVYLYKRGTFYPFAPLPGGTEKRDNQLELQVRGALGDDLRVEKDLSRWFPVWGAPGL
>NC_021177.1|WP_015610571.1|4798325_4798754_+|Zn-ribbon-domain-containing-OB-fold-protein
MSPERAASPRFDLPEPDAFTRPYWDAAGEGRLLIRRCAGCGRAHHYPREFCPYCWSEDVEWEHASGHATLYTWSVVHRNDLPPFGDRVPYVAAVVDLAEGPRMMTEVVECAHAGLRIGMGLTVTFRCGEEGGESVAVFRPSP
>NC_021177.1|WP_043972972.1|4809020_4809734_-|hypothetical-protein
MIRNILGSLVALAGAASAVLSPFRDWYGGRAGQDYRVRDLFGGITATESGVLVSILLPFLFAALLVIAGVVLRSRIAVALAGLVVLGFTILWMVRQGQAEGALTVGGDGAGLQVGVANALAGGVLMLIGALLMSGRGAGARSQARARARARARREQEPVEPYAAPPADQVDTWPPTQEPGMSTHTSPWPEPEVDPYTGPDPHDPRTRSYPQAERGPEPGDPGDPRDPVHPPHRPPER
>NC_021177.1|WP_015610582.1|4809965_4810496_+|hypothetical-protein
MMRRQMKLAAVLVVVVLALTGFTTSTSGGKGSKSKGSSSSGGGCSNSKKSNSGYRHTDYDDDDYDDNSSGSSGSSYGTPTPTASDGPAVRVIRCAQPRKGKRKAVTASVVELRSKDTGSHTYEVDVTFYDARGNTVDTAETTTTLDAGDVRNLTVRMESPRRVSEVKRCEVTAQLL
>NC_021177.1|WP_015610583.1|4810529_4811318_-|enoyl-CoA-hydratase/isomerase-family-protein
MALRIERDGQRGVALVILDRPEKLNAIDVETAEELAALWRELRYDESVRAAVLTGAGTRAFCTGIDRGVKVPQPPSPYAIDDPLLRIGPKANDLWKPVVAAVEGMACGGAFYLLGEAEFIVASREATFFDPHTTYGMVSAYEAIAMAQRMPFGEVARMSLMGTAERVSAERAYATGLVSEVTEPGGAVAAALRAAAVIAGYPTEAVQGTVRAVWSAKEAARTQALAQAPALIALGNLAPERQAELFEGRGGGGGGGGAPVVR
>NC_021177.1|WP_015610584.1|4811321_4811774_-|DUF35-domain-containing-protein
MGVNDSLLLPVLDEDGAPFWEYAARGELRVQACASPTCGELRFPPRPCCPHCGSFDSEWRAMSGRGRLWSYVIPHPPLLPAYAEQAPYNAVLVELAEAPRIRLAGNVVASADAPLNSVDPGRLRIGAPVRAVFCPVGPDGFTLVRWLLER
>NC_021177.1|WP_015610585.1|4811786_4812935_-|lipid-transfer-protein
MATLKDATAIAGIGQTAFAKRLPESEKTLACRAILAALDDAGIAPSEVDGFASYTMEETDEVEVAKAIGAGDVTFFSKVGYGGGGPCATLAHLAAAVATGQASVGVAWRSRKRGSGPRPWKNTAVQLPTPAQWTRPYGLLRPADEIGMLARRYMHEYGATRDHLFNVALACRNRANQNPAAIMYDRPLTREMYMTSRWISEPLCLFDNCLETDGALACVIVSAERARDCRQKPVYLHSVAQGLPAQHHGMVNYWNDDPLTGPAWTAARQLWKQGDFGPEDVDVAQIYDAFTPLVPLSLEGYGFCARGEGGAFTEGGALESGGRLPINTGGGGLSEAYVHGFNLITEGVKQLRGTSTAQVPDAATCLVTAGEGVPTSAVLLRN
>NC_021177.1|WP_043972976.1|4813073_4814630_+|fatty-acid--CoA-ligase-family-protein
MRGDEEWGSIPGLVREAARRYGPAEAVVEGRTRLTYAGLGDRVERAAAACMAAGVERGDRVAIWAPNTLDWIVSALGAVSAGAVLVPLNTRFKGNEAAHILRRSRARLLFVTGTFLGTSYVASLRRAEVKLPDLERVVVLAETAPEDYTSWPDFLAAGEGVPSSAVREREAAIAPSDPSDIIYTSGTTGAPKGAVITHAQTLRAYEIWSDLAGLREGDRYLIVNPFFHTFGYKAGIIACLMRGATMVPQPVFGVDTVLANIAAERISVLPGPPTLHQSLLDHPARDSHDLSALRLVVTGAAVVPLRLVERLRGELHIATVLTAYGLSEASGIVTMCRRGDAPQTVATTSGRAIPGTEVRVLAGPGEPGEIQVRGFNVMSGYFEDPQTTAATITPDGWLRTGDVGVLDEAGNLRITDRIKDMFIVGGFNAYPAEIEQLLGLHPDIADVAVVGVPDPRLGEVGKAYAVRRRGATLTADDLIAWSRREMANFKVPRTVEFVPELPRNASGKVVKGELRGRG
>NC_021177.1|WP_015610588.1|4814900_4815299_-|twitching-motility-protein-PilT
MSGALVLDSEGLAQAVLRGREVQEWLEAARAADLPVITSAVILTEVIHPRISTTALSWTLSRLRVEPVSQAIAQSAATLLIGAGLHGHKYAIDALLCATALTHPGRVTVLTSDTEDIGLLTAGHPRVTAEKI
>NC_021177.1|WP_015610589.1|4815295_4815574_-|hypothetical-protein
MTEAPDFPPGDGPSSGISVSLTAGTLHAIRERVGKRGVSAYLEAAAQRQIERDNLDELLADFEKVNGPTDAASVADKRAKLTSNPPEAGATA
>NC_021177.1|WP_015610590.1|4815763_4815943_-|hypothetical-protein
MADAKKNPVIKPQDMHATGGETTNGDMHATGSPLKPKDMHATGGDTTNGDMHATSEPAN
>NC_021177.1|WP_015610591.1|4816175_4819142_-|AfsR/SARP-family-transcriptional-regulator
MDRDHGPRVRVPEQRAPEEPGAADSLRFTVLGPVRAWRGAESLPSGSPQQRALLAALLLREGRTATAGELIDAFWGEDPPSQALATIRTYASRLRKILGQDTLVSEAGGYALRIGRGALDLTLAQDLAAAAEKARAGGNRLQARTLINKVLGLWDGEALASVPGPYAENQRTRLEEWRLQLTEARLDLDLEVGSHAEAVSELTALTAAHPLRERLRELLMVALYRSGRQAEALAVYADTRRLLSEELGVDPRPELAQLQQRILRADEELARPADEPAPAAAPLKPAQLPATVPDFTGRDSFVRDLGAQLASAEGSVMAVSALAGIGGVGKTTLAVHVAHQARPHFPDGQLYVDLQGAGARAAEPETVLGSFLRALGTAESAIPGTLDERAALYRSTLDGRRILVLLDNAHDAAQIRPLLPGTPGCAALVTSRVRMVDLAGAHLVDLDVMSPDEALQLFTRIVGAERVGAEREAALDVVAACGFLPLAIRIAASRLAARRTWTVSVLAVKLADERRRLDELQAGDLAVKATFELGYGQLEPAQARAFRLLGLADGPDISLAAAAALLNLEPHTAEDLLEALVDTSLLESAAPGRYRYHDLVRLYARACAERDEQPPVERELALSRLLDFYLATAAGVYALERPADRLVDHLEPTDHPGLTFGNRQAALDWLYTEAGPLLACVRRSSEPSTLRRGVDLLWAALDLGESGANAKQYETAAIALLEAARTSGDRRSEVRALVTLADVHHTSGRFDQAEQEAESVMILVEADQDPLPACWASNARGIMALYQSRHDDGERYFNQAIDNFRSIQDRPGEASALCNLSRIHLATGRTDSAVALAEEGTAVYDSMGHALRSANGRYALGMALTQSGRFAEASERLLEALDVFRASRQRLWEGMTLFRLAEVDLAAGNATDAAVKAEQALTALRGIGGEWRRGNVLTVLGRSLAQIGQFGRAEVCWREALGIYDALGSQEAAEVRSLLSSAASTSPS

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Crispr_ID: NC_021177_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_17

4815783-4815877

Orphan

Consensus_repeat	Method
GTGGCGTGCATGTCGCCGTTCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_17

>merge|NC_021177|17|4815783-4815877|CRISPRCasFinder
GTGGCGTGCATGTCGCCGTTCGTGGTGTCCCCGCCGGTCGCGTGCATGTCCTTCGGCTTGAGCGGGCTGCCGGTGGCGTGCATGTCGCCGTTGGT

>NC_021177|17|17|4815783-4815877|CRISPRCasFinder
GTGGCGTGCATGTCGCCGTTCGT	GGTGTCCCCGCCGGTCGCGTGCATGTCCTTCGGCTTGAGCGGGCTGCCG
GTGGCGTGCATGTCGCCGTTGGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_032760052.1\|4819456_4820686_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NC_021177.1\|WP_043972976.1\|4813073_4814630_+\|fatty-acid--CoA-ligase-family-protein	unknown	unknown	gnl\|CDD\|236072
NC_021177.1\|WP_015610585.1\|4811786_4812935_-\|lipid-transfer-protein	unknown	unknown	gnl\|CDD\|181147
NC_021177.1\|WP_015610598.1\|4826605_4827256_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236419
NC_021177.1\|WP_015610600.1\|4828321_4828882_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237864
NC_021177.1\|WP_032760062.1\|4806482_4808891_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|270916
NC_021177.1\|WP_043972972.1\|4809020_4809734_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236251
NC_021177.1\|WP_015610591.1\|4816175_4819142_-\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|276938
NC_021177.1\|WP_015610595.1\|4822205_4823099_+\|menaquinone-biosynthesis-protein	unknown	unknown	gnl\|CDD\|270352
NC_021177.1\|WP_015610589.1\|4815295_4815574_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610588.1\|4814900_4815299_-\|twitching-motility-protein-PilT	unknown	unknown	gnl\|CDD\|350222
NC_021177.1\|WP_015610582.1\|4809965_4810496_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610594.1\|4821738_4821942_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_021177.1\|WP_043972979.1\|4820736_4821564_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133382
NC_021177.1\|WP_015610599.1\|4827284_4828325_-\|DUF3152-domain-containing-protein	unknown	unknown	gnl\|CDD\|371483
NC_021177.1\|WP_015610583.1\|4810529_4811318_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NC_021177.1\|WP_015610597.1\|4825398_4826598_+\|dehypoxanthine-futalosine-cyclase	unknown	unknown	gnl\|CDD\|274731
NC_021177.1\|WP_015610584.1\|4811321_4811774_-\|DUF35-domain-containing-protein	unknown	unknown	gnl\|CDD\|224462
NC_021177.1\|WP_015610596.1\|4823368_4825327_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NC_021177.1\|WP_015610579.1\|4805400_4806210_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_032760052.1\|4819456_4820686_+\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	1.41053e-30
NC_021177.1\|WP_043972976.1\|4813073_4814630_+\|fatty-acid--CoA-ligase-family-protein	gnl\|CDD\|236072	PRK07656, PRK07656, long-chain-fatty-acid--CoA ligase; Validated.	0
NC_021177.1\|WP_015610585.1\|4811786_4812935_-\|lipid-transfer-protein	gnl\|CDD\|181147	PRK07855, PRK07855, lipid-transfer protein; Provisional.	0
NC_021177.1\|WP_015610598.1\|4826605_4827256_+\|hypothetical-protein	gnl\|CDD\|236419	PRK09228, PRK09228, guanine deaminase; Provisional.	5.63366e-05
NC_021177.1\|WP_032760062.1\|4806482_4808891_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.29254e-75
NC_021177.1\|WP_043972972.1\|4809020_4809734_-\|hypothetical-protein	gnl\|CDD\|236251	PRK08375, PRK08375, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0.00326094
NC_021177.1\|WP_015610591.1\|4816175_4819142_-\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	3.69679e-37
NC_021177.1\|WP_015610595.1\|4822205_4823099_+\|menaquinone-biosynthesis-protein	gnl\|CDD\|270352	cd13634, PBP2_Sco4506, The conserved hypothetical protein SCO4506 exhibits the type 2 periplasmic-binidng protein fold. This group includes the SCO4506 protein from Streptomyces coelicolor and related hypothetical proteins. SCO4506 is an ortholog of Ttha1568 (MqnD) from Thermus thermophilies HB8. MqnD is an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. SCO4506 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.31394e-113
NC_021177.1\|WP_015610588.1\|4814900_4815299_-\|twitching-motility-protein-PilT	gnl\|CDD\|350222	cd09874, PIN_MT3492-like, VapC-like PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis CDC1551, hypothetical protein MT3492, and similar bacterial and archaeal proteins are included in this subfamily. They are PIN domain homologs of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	0.000720633
NC_021177.1\|WP_015610596.1\|4823368_4825327_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.42389e-90
NC_021177.1\|WP_015610594.1\|4821738_4821942_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.43097e-36
NC_021177.1\|WP_043972979.1\|4820736_4821564_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	6.62389e-46
NC_021177.1\|WP_015610599.1\|4827284_4828325_-\|DUF3152-domain-containing-protein	gnl\|CDD\|371483	pfam11350, DUF3152, Protein of unknown function (DUF3152). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	5.18734e-32
NC_021177.1\|WP_015610583.1\|4810529_4811318_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	5.9381e-38
NC_021177.1\|WP_015610597.1\|4825398_4826598_+\|dehypoxanthine-futalosine-cyclase	gnl\|CDD\|274731	TIGR03699, menaquin_MqnC, dehypoxanthine futalosine cyclase. members of this protein family are involved in menaquinone biosynthesis by an alternate pathway via futalosine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0
NC_021177.1\|WP_015610584.1\|4811321_4811774_-\|DUF35-domain-containing-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	1.06983e-22
NC_021177.1\|WP_015610600.1\|4828321_4828882_-\|hypothetical-protein	gnl\|CDD\|237864	PRK14950, PRK14950, DNA polymerase III subunits gamma and tau; Provisional.	9.67151e-06
NC_021177.1\|WP_015610579.1\|4805400_4806210_+\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	2.33639e-27

>NC_021177.1|WP_015610589.1|4815295_4815574_-|hypothetical-protein
MTEAPDFPPGDGPSSGISVSLTAGTLHAIRERVGKRGVSAYLEAAAQRQIERDNLDELLADFEKVNGPTDAASVADKRAKLTSNPPEAGATA
>NC_021177.1|WP_015610588.1|4814900_4815299_-|twitching-motility-protein-PilT
MSGALVLDSEGLAQAVLRGREVQEWLEAARAADLPVITSAVILTEVIHPRISTTALSWTLSRLRVEPVSQAIAQSAATLLIGAGLHGHKYAIDALLCATALTHPGRVTVLTSDTEDIGLLTAGHPRVTAEKI
>NC_021177.1|WP_043972976.1|4813073_4814630_+|fatty-acid--CoA-ligase-family-protein
MRGDEEWGSIPGLVREAARRYGPAEAVVEGRTRLTYAGLGDRVERAAAACMAAGVERGDRVAIWAPNTLDWIVSALGAVSAGAVLVPLNTRFKGNEAAHILRRSRARLLFVTGTFLGTSYVASLRRAEVKLPDLERVVVLAETAPEDYTSWPDFLAAGEGVPSSAVREREAAIAPSDPSDIIYTSGTTGAPKGAVITHAQTLRAYEIWSDLAGLREGDRYLIVNPFFHTFGYKAGIIACLMRGATMVPQPVFGVDTVLANIAAERISVLPGPPTLHQSLLDHPARDSHDLSALRLVVTGAAVVPLRLVERLRGELHIATVLTAYGLSEASGIVTMCRRGDAPQTVATTSGRAIPGTEVRVLAGPGEPGEIQVRGFNVMSGYFEDPQTTAATITPDGWLRTGDVGVLDEAGNLRITDRIKDMFIVGGFNAYPAEIEQLLGLHPDIADVAVVGVPDPRLGEVGKAYAVRRRGATLTADDLIAWSRREMANFKVPRTVEFVPELPRNASGKVVKGELRGRG
>NC_021177.1|WP_015610585.1|4811786_4812935_-|lipid-transfer-protein
MATLKDATAIAGIGQTAFAKRLPESEKTLACRAILAALDDAGIAPSEVDGFASYTMEETDEVEVAKAIGAGDVTFFSKVGYGGGGPCATLAHLAAAVATGQASVGVAWRSRKRGSGPRPWKNTAVQLPTPAQWTRPYGLLRPADEIGMLARRYMHEYGATRDHLFNVALACRNRANQNPAAIMYDRPLTREMYMTSRWISEPLCLFDNCLETDGALACVIVSAERARDCRQKPVYLHSVAQGLPAQHHGMVNYWNDDPLTGPAWTAARQLWKQGDFGPEDVDVAQIYDAFTPLVPLSLEGYGFCARGEGGAFTEGGALESGGRLPINTGGGGLSEAYVHGFNLITEGVKQLRGTSTAQVPDAATCLVTAGEGVPTSAVLLRN
>NC_021177.1|WP_015610584.1|4811321_4811774_-|DUF35-domain-containing-protein
MGVNDSLLLPVLDEDGAPFWEYAARGELRVQACASPTCGELRFPPRPCCPHCGSFDSEWRAMSGRGRLWSYVIPHPPLLPAYAEQAPYNAVLVELAEAPRIRLAGNVVASADAPLNSVDPGRLRIGAPVRAVFCPVGPDGFTLVRWLLER
>NC_021177.1|WP_015610583.1|4810529_4811318_-|enoyl-CoA-hydratase/isomerase-family-protein
MALRIERDGQRGVALVILDRPEKLNAIDVETAEELAALWRELRYDESVRAAVLTGAGTRAFCTGIDRGVKVPQPPSPYAIDDPLLRIGPKANDLWKPVVAAVEGMACGGAFYLLGEAEFIVASREATFFDPHTTYGMVSAYEAIAMAQRMPFGEVARMSLMGTAERVSAERAYATGLVSEVTEPGGAVAAALRAAAVIAGYPTEAVQGTVRAVWSAKEAARTQALAQAPALIALGNLAPERQAELFEGRGGGGGGGGAPVVR
>NC_021177.1|WP_015610582.1|4809965_4810496_+|hypothetical-protein
MMRRQMKLAAVLVVVVLALTGFTTSTSGGKGSKSKGSSSSGGGCSNSKKSNSGYRHTDYDDDDYDDNSSGSSGSSYGTPTPTASDGPAVRVIRCAQPRKGKRKAVTASVVELRSKDTGSHTYEVDVTFYDARGNTVDTAETTTTLDAGDVRNLTVRMESPRRVSEVKRCEVTAQLL
>NC_021177.1|WP_043972972.1|4809020_4809734_-|hypothetical-protein
MIRNILGSLVALAGAASAVLSPFRDWYGGRAGQDYRVRDLFGGITATESGVLVSILLPFLFAALLVIAGVVLRSRIAVALAGLVVLGFTILWMVRQGQAEGALTVGGDGAGLQVGVANALAGGVLMLIGALLMSGRGAGARSQARARARARARREQEPVEPYAAPPADQVDTWPPTQEPGMSTHTSPWPEPEVDPYTGPDPHDPRTRSYPQAERGPEPGDPGDPRDPVHPPHRPPER
>NC_021177.1|WP_032760062.1|4806482_4808891_+|PQQ-binding-like-beta-propeller-repeat-protein
MEQLTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGPMPTQAVRWLAAGIAEALQSIHGAGLVHRDMKPSNVLVVEDGPRVIDFGIASGVSNTRLTMTNVAVGTPAYMSPEQARDSRSVTGASDIFSLGSTLVFAATGHAPFHGANPVETVFMLLREGPDTEGLPDDLRPLIESCMQMDPTQRPSPADLQAQLAPHLFASGSDDSGTASAWLPSLATAMIERRRGGGRTAPPAAPSAPPPRPPQPPRAPDRAPDRGPDWRSGGDLRSPSPLSSPAPVSSPAPSPDGGPVHLPGAKAPIGPGPRAGEGRGAAAAHPAAATGWVRPPAGLNGSDPASTAPVPAPGPAPDASPAAPDRWRPWRFRMSNDVWGTPVVSGDLLYVTSFEIHALDVGNGRRQFKTRDVAWAMAVEGGRIHASDGPSLYALDAASGTEQWRVRTDAWVYALKADRGTVLTATRGGGVQGWEASNGDKLWEITGVQSDFETVEAAPVIHDGTVYVWQDARLRALDARTGLERWSYPIGDAASCGGVPVRVTPAPDGYVYVAAGTRVLAVENVSGRVRWHFESPAVFLSPPAFAQGPAVTGGGVYLADYLGTVYALDATTGKDRWRIATEARASVEPVLVAVGNVHVGSGSALYTLDAVTGTPKWRFAAGGDVVGSPVVADGRVHFGSADHVLYTLDAAGGQLRWKLATGGEITGSPVAQAGVVYACSKDRCVYALDALKGTGTGNRART
>NC_021177.1|WP_015610579.1|4805400_4806210_+|VOC-family-protein
MAAFAHSAPCWADVQLSDLEAGKRFYGGLFGWTFRAGDGMPFADALSGGRLVAALAAKKDGRMPTAWGVYFATDDIRATVAAIREHGGQIITDPVRAGQAGIVAQAADPGGAVFGLWQPEEREGFEKQNEPGSFCWTEVHTRRPEEVDPFYEKVFGFRGTDLDEAGNDVSDDAEALVDFRMWSPEGAEPGPDSAVGGRSVITDAFPAEMPSYFLTYFAVADCDAAAELAVQLGGRVSAPPFDIPYGRMAVLHDDQGALFAVLQPSELLP
>NC_021177.1|WP_015610591.1|4816175_4819142_-|AfsR/SARP-family-transcriptional-regulator
MDRDHGPRVRVPEQRAPEEPGAADSLRFTVLGPVRAWRGAESLPSGSPQQRALLAALLLREGRTATAGELIDAFWGEDPPSQALATIRTYASRLRKILGQDTLVSEAGGYALRIGRGALDLTLAQDLAAAAEKARAGGNRLQARTLINKVLGLWDGEALASVPGPYAENQRTRLEEWRLQLTEARLDLDLEVGSHAEAVSELTALTAAHPLRERLRELLMVALYRSGRQAEALAVYADTRRLLSEELGVDPRPELAQLQQRILRADEELARPADEPAPAAAPLKPAQLPATVPDFTGRDSFVRDLGAQLASAEGSVMAVSALAGIGGVGKTTLAVHVAHQARPHFPDGQLYVDLQGAGARAAEPETVLGSFLRALGTAESAIPGTLDERAALYRSTLDGRRILVLLDNAHDAAQIRPLLPGTPGCAALVTSRVRMVDLAGAHLVDLDVMSPDEALQLFTRIVGAERVGAEREAALDVVAACGFLPLAIRIAASRLAARRTWTVSVLAVKLADERRRLDELQAGDLAVKATFELGYGQLEPAQARAFRLLGLADGPDISLAAAAALLNLEPHTAEDLLEALVDTSLLESAAPGRYRYHDLVRLYARACAERDEQPPVERELALSRLLDFYLATAAGVYALERPADRLVDHLEPTDHPGLTFGNRQAALDWLYTEAGPLLACVRRSSEPSTLRRGVDLLWAALDLGESGANAKQYETAAIALLEAARTSGDRRSEVRALVTLADVHHTSGRFDQAEQEAESVMILVEADQDPLPACWASNARGIMALYQSRHDDGERYFNQAIDNFRSIQDRPGEASALCNLSRIHLATGRTDSAVALAEEGTAVYDSMGHALRSANGRYALGMALTQSGRFAEASERLLEALDVFRASRQRLWEGMTLFRLAEVDLAAGNATDAAVKAEQALTALRGIGGEWRRGNVLTVLGRSLAQIGQFGRAEVCWREALGIYDALGSQEAAEVRSLLSSAASTSPS
>NC_021177.1|WP_032760052.1|4819456_4820686_+|amidohydrolase
METFPKIISVDDHTVEPAHVWRDRLPSKYADSGPRVVRAPLKEMTFMGGKFAPVMGAEGDDGPVGDWWVYEDLHRPLTRLDTAVGYDRDEIKLEIITYEQMRPGSFSVPDRLADMDVNHVQSALCFPTFPRFCGQTFTEAKNRELGLLGVRAYNDWMVEEWCGPEAHGRLIPLTLVPLWDAELAAAEVRRNAARGVRAVAFSEIPPHLGLPSIHTDEWDPFLAACDETGTVIAMHIGSSSRMPSTSADAPPAVGSTITFANCCFSMVDWLMSGKFERFPNLKIMYAEGQIGWIPYILERADVVWEENRAWGGVADKVHRPPSELFADHVYGCFFDDAFGLKNLDAIGVGNVLYETDYPHSDSTWPKSREVGEAQMGHLAPDVVDRIVRGNAIDLLGLTDDGLWAGARQS
>NC_021177.1|WP_043972979.1|4820736_4821564_-|MerR-family-transcriptional-regulator
MFTIGDFARYGRVSPRMLRHYDAIGLLRPDRTDPATGYRFYGAAQLARLNRIIALKDLGFTLQQVRAVLDEQVGPEELRGMLRLRRAELAEAVAAASARLAQVEARLRSIESEGHMPADDVVIKTVPAVRVAELTGTAASYEPHHIGPVIGPLYEELLPLLEGAGLRPTGPGIARYEDAPGGGGAIVVHAGVTVAAPVGPVGGTGVSVVELPPFEAATVVHRGAMDDVVPTVQTLARWLDANGYRSTGYTREVSLECPPDRSRWVTELQEPVTKV
>NC_021177.1|WP_015610594.1|4821738_4821942_-|cold-shock-protein
MATGTVKWFNAEKGFGFIAQDGGGPDVFVHYSAINASGFRSLEENQQVTFDVTQGPKGPQAENVIPA
>NC_021177.1|WP_015610595.1|4822205_4823099_+|menaquinone-biosynthesis-protein
MDNSTVSASEAPAGDSDDRRSRPRVGHIQFLNCLPLYWGLARTGTLLDLELSKDTPERLSEQLIRGDLDIGPVTLVEYLRNADDLVAFPDIAVGCDGPVMSCVIVSQLPLDQLDRARVALGSTSRTSVRLAQLLLAERYGVRPDYYTCPPDLGLMMQEADAAVLIGDAALRANLHDAPRLGLQVHDLGQMWKEWTGLPFVFAVWAARKDFLAAHPETAAKVHEAFLASRDLSLEEVTKVAEQAARWEAFDAEVLEQYFTTLDFRFGPDQLAGVREFARRTGPDTGYPADVHVELLGG
>NC_021177.1|WP_015610596.1|4823368_4825327_+|serine/threonine-protein-kinase
MQPLEAGEPHTIGAYRLLGRLGAGGMGRVYLGRSAGGRTVAVKVVHPHFALDEQFRARFRREVESARRIGAQWTAPVLDADPDAPVPWVATGYVAGPPLSQAITEHGPLPEHAVRTLGAGLAEALHVVHGQGIVHRDVKPSNVLLALDGPRLIDFGIARALGATVSLTSTGVSVGSPGYMAPEQIRGRDVSGAADVFSLGAVLAYAATGAAPFSGDSSAVLLYKVVHEEPELGDLEGELREVVAGCLAKDPDARPAPADLARTLAPDGAAAMVAAGWLPGRLVAEVSRSAVALLDLEPQDAPVGSGPVPFSSASLGAGFGAGTGARTDTDPHDGPGHDARGGDGSRTGSDARTGSDPDPRVGSGPDPRSRSGVPTGSEAGLIGVFGPPLVHVPDGPPGTPPPPTAPPGDGHGGGFPGQRTHDPRFSVTVSADSQASTGRGAGADDGARRSRRVSCTVALAVAGAFAVVAFSSGLLDGFLPGGDADQRKGNDTAATPPSATATASEDPAPAGSADPSGTPSDAGEAPVGEVPKAFVGTWEGPLTEKTNGQPHGTLTAVFTEGGKGTQVVRMSNTISQLGITVTCNSVGTLTSGTGQELKVRERTDPDRPSTPGLCTTTEADLVFRLTDDGTLGYRSQERAAGLPYGELTRSGG
>NC_021177.1|WP_015610597.1|4825398_4826598_+|dehypoxanthine-futalosine-cyclase
MTEKADLQPVLDRAAEGGRITPEEALDLYRSAPLHALGAAADAVRRRRYAGTEHIATYIIERNINYTNVCVTACKFCAFYAPPKDKAKGWTRDIEDILRRCAETVELGGTQIMFQGGHHPDFGVEYYEEHFSAIKKAYPQLVIHSLGASEIEHMARISKVSAEEAISRIHAAGLDSFAGAGAELLPARPRTAIAPLKESGERWLEIMEIAHGLGVESTSTMLMGTGETNAERIEHLKMIRDVQDRTGGFRAFIPYTYQPENNKLKGQTQATLFEYLRMISIARLFLDNVAHIQGSWLTTGKEVGQLSLHYGADDLGSIMLEENVVSSAGAKHRSNRMEIIDLIRKADRVPAQRATTYEHLVVHDDPANDPVDERVVSHISSTAIAGGTAHPELKLLNAN
>NC_021177.1|WP_015610598.1|4826605_4827256_+|hypothetical-protein
MLTVHAAPLVLPVGAAAVAEGAVAVDGDRIAAIGPYEEVVAAHPAARVRRWPGLLTPGLRQDRARELLTRCYHPDPREADELGELPLWGEEFERLAATMDTARRAGSVRRGLQRMLRYGTTHVVGPFGADEPALRTALSRSGLVQVPAAGGPAAPPDLDPFAAGGDLATTAHGPLTVGGRADFAAFDVADEAALRAGGARHCVATVLAGRLVHRAR
>NC_021177.1|WP_015610599.1|4827284_4828325_-|DUF3152-domain-containing-protein
MTGRRGLGTLPRDEPARDTETFRLRALPGPRTGDGGPGRAPGGRSLSRSSSRSGSRSGTRFGARSDSRSRSRERRRRRNRRRTAGLVVLALAAVALVAVLIDRPWQNGDPSVTAGAGPGTGDDNAEAPVAPAPPPATPSAAPASPTPSPPAGERPPSASDVPASGPGTFTVARAGVTTSGKGEPYRVEVEDGIGVDPDRAAQDIAAILADPRGWSHGGERTFRQVTDKSAGLVVKIGTAATTDRLCGAYGLKTRGEVNCRGGEQVMVNLKRWQLGSPQFDGPVAEYRALIINHEVGHWLGRGHETCPGKGRPAPAMMQQIDGLKGCVANAWPYDAKGRYLGGPKVP
>NC_021177.1|WP_015610600.1|4828321_4828882_-|hypothetical-protein
MTPEPLPGSPEEEIFRDALHRTADTLAPPLDLVPEAVREGRLRRARSRGLAVVGAFVAVTAVTLGLALLGPLLRPAPDTGPAAPAPGPSLTRPVPDPSLTRPTPGPSPDPTEPVTGMPTPTPSSPSATPPWTTSPAAPTGGPSGALPGGPSATAPGGPSGAVPATPGPTRSGAALFAPSPAPGTTK

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Click the colored protein region to show detailed information

Crispr_ID: NC_021177_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_18

4934734-4934818

Orphan

Consensus_repeat	Method
TCCGTCCTCAAACGCCGGACGGGCTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_18

>merge|NC_021177|18|4934734-4934818|CRISPRCasFinder
TCCGTCCTCAAACGCCGGACGGGCTGGATATGGGTGCGGGTTCGTCCTCCGCGAGGGTTCCGTCCTCAAGCGCCGGACGGGCTGG

>NC_021177|18|18|4934734-4934818|CRISPRCasFinder
TCCGTCCTCAAACGCCGGACGGGCTGG	ATATGGGTGCGGGTTCGTCCTCCGCGAGGGT
TCCGTCCTCAAGCGCCGGACGGGCTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015610706.1\|4940367_4941567_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227699
NC_021177.1\|WP_015610694.1\|4921066_4921969_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610707.1\|4941644_4942397_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610698.1\|4931769_4931997_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610695.1\|4922897_4923281_+\|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl\|CDD\|234671
NC_021177.1\|WP_015610703.1\|4936805_4938008_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610700.1\|4933136_4934597_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610693.1\|4920161_4920884_+\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071
NC_021177.1\|WP_003966993.1\|4931512_4931773_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_007445921.1\|4922255_4922813_+\|50S-ribosomal-protein-L10	unknown	unknown	gnl\|CDD\|234632
NC_021177.1\|WP_015610705.1\|4939087_4940371_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227699
NC_021177.1\|WP_015610696.1\|4923905_4927391_+\|DNA-directed-RNA-polymerase-subunit-beta	unknown	unknown	gnl\|CDD\|234749
NC_021177.1\|WP_015610704.1\|4938060_4939041_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368574
NC_021177.1\|WP_043973050.1\|4942890_4943238_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610702.1\|4935628_4936735_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_043973048.1\|4942482_4942884_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610699.1\|4932016_4933024_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|376556
NC_021177.1\|WP_015610710.1\|4943303_4943594_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610697.1\|4927521_4931421_+\|DNA-directed-RNA-polymerase-subunit-beta'	unknown	unknown	gnl\|CDD\|234794
NC_021177.1\|WP_015610701.1\|4934908_4935625_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_007445921.1\|4922255_4922813_+\|50S-ribosomal-protein-L10	gnl\|CDD\|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	2.63125e-70
NC_021177.1\|WP_015610705.1\|4939087_4940371_-\|hypothetical-protein	gnl\|CDD\|227699	COG5412, COG5412, Phage-related protein [Function unknown].	0.000376374
NC_021177.1\|WP_015610696.1\|4923905_4927391_+\|DNA-directed-RNA-polymerase-subunit-beta	gnl\|CDD\|234749	PRK00405, rpoB, DNA-directed RNA polymerase subunit beta; Reviewed.	0
NC_021177.1\|WP_015610693.1\|4920161_4920884_+\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	2.52485e-142
NC_021177.1\|WP_015610704.1\|4938060_4939041_-\|hypothetical-protein	gnl\|CDD\|368574	pfam05709, Sipho_tail, Phage tail protein. This family consists of several Siphovirus and other phage tail component proteins as well as some bacterial proteins of unknown function.	8.06885e-06
NC_021177.1\|WP_015610699.1\|4932016_4933024_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|376556	pfam01510, Amidase_2, N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.	1.68578e-18
NC_021177.1\|WP_015610695.1\|4922897_4923281_+\|50S-ribosomal-protein-L7/L12	gnl\|CDD\|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	7.40619e-42
NC_021177.1\|WP_015610697.1\|4927521_4931421_+\|DNA-directed-RNA-polymerase-subunit-beta'	gnl\|CDD\|234794	PRK00566, PRK00566, DNA-directed RNA polymerase subunit beta'; Provisional.	0
NC_021177.1\|WP_015610706.1\|4940367_4941567_-\|hypothetical-protein	gnl\|CDD\|227699	COG5412, COG5412, Phage-related protein [Function unknown].	9.06342e-10

>NC_021177.1|WP_015610700.1|4933136_4934597_-|hypothetical-protein
MLPETIPTVTLTARYLTPDGRPMSGTVDFRPPALLTHAEEDLFLGGPTRATLDPEGRLRIVLPATDGPGWNPAVWTYTVTERLSGLGRNSRSYQIVLSADHPTVDLADIAPADPANPQYVAVPGPAGRPGELGPQGPAGPAGAVHSVNGKTDPDILLTASDVSAVDAARAGAPGGVATLGADGLVPAAQLPAGGGAVASVNGRTGNVTLAATDVGALSQAAGDARYLAVDGSPVTSVNGRTGPVVLTAADVSAVASGDAVLLTGDQTVQGAKTFAAPPLTTVTPTTADQLTRRGYVDAVSSAGSWSPSAVGFAGWAFDPACGSATTPQYCINGWVYLIGVPLHAQTTVRNIAFYIPGYVGNTLGPASFAGLYTSAGARVGLTAPLNTLLSATEGRTVVCPLTTAYNAAPGNYWVALVVNGPNPSNSGPAFLRGSSVGQAPGGSARMPNAFIRHGRLNATGQTSLPASFNTANITADSNAIWAALAS
>NC_021177.1|WP_015610699.1|4932016_4933024_-|N-acetylmuramoyl-L-alanine-amidase
MATPLTADRLLAALHAEGVTVVEHPGWRTHHRNHKGAWGPVNGVMIHHTVSSGSAASVALCRDGYAALPGPLCHGVIDKAGTVHLISAGRANHAGGGDPAVLRRVTAEDYGDRPPAPRAHDGSTGAVDGNARFYGFECVNLGNGRDPWPTAQLDAIERASAAICRAHGWSARSVIGHSEWSSAKIDPRGFTMPSMRTRVTTRLAAPAKPPTKPTKPTQPAKPSKPTQPSKPTQPSKPSNPTAPTSPTTPRYQPFPGPSFFTARPSSPVITAMGRRLAAEGCGTYAVGPGPRWTEADRSSYAAWQRKLGFRGSEADGWPGRTSWNALKVPYTAKVP
>NC_021177.1|WP_015610698.1|4931769_4931997_-|hypothetical-protein
MSDAARRTARTVLQTALALAVLLPALVDASGVPATLPRVAGALAVAGTVTRVMALPGVQALLPRWLRTEPPEGRP
>NC_021177.1|WP_003966993.1|4931512_4931773_-|hypothetical-protein
MTDTDPNNPVAVALELERMRGSLEAGFARADGQLALLVQRSDQTDKQLADHEARLDLLERSRWPLASIAALTATAGVAIAVWETLR
>NC_021177.1|WP_015610697.1|4927521_4931421_+|DNA-directed-RNA-polymerase-subunit-beta'
MLDVNFFDELRIGLATADDIRTWSHGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKVIYFAAYMITFVDEERRTRDLPSLEAHVSVERQQTENRRDSDLEARAKKLETDLAELEAEGAKADVRRKVREGAEREMKQLRDRAQREIDRLDEVWSRFKNLKVQDLEGDELLYRELRDRFGTYFDGCMGAAALQKRLESFDLDEEAERLREIIRTGKGQKKTRALKRLKVVSAFLQTSNKPKGMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSARSVIVVGPQLKLHQCGLPKAMALELFKPFVMKRLVDLNHAQNIKSAKRMVERGRTVVYDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQIHPLVCTAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILKPADGRPVTMPTQDMVLGLFFLTTDGELRDTKGEGRAFGSTAEAIMAFDAGELALQSTVDIRFPVGTIPPRGWVPPVAEEGEPEYQPGDTFRLRTSLGRALFNELLPEDYPFVDYSVGKKQLSEIVNDLAERYPKVIVAATLDNLKAAGFHWATRSGVTVAISDIVVPEAKKAIVKGYEDQDEKVQKQYERGLITKDERTQELIAIWTKATNEVAEAMNANFPKTNPIFMMVDSGARGNMMQMRQIAGMRGLVSNAKNETIPRPIKASFREGLTVLEYFISTHGARKGLADTALRTADSGYLTRRLVDVSQDVIIREEDCGTDRGLKLKIAVKGADGVLRKTEDVETSVYARMLAEDVVVDGKVIAPANVDLGDVLIDALVGAGVEEVKTRSVLTCESAVGTCAFCYGRSLATGKLVDIGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRVVELFEARTPKGVAPISEAKGRVRIEETEKTKKLVVTPDDGSDETAFPISKRARLLVGEGDPVEVGQKLTVGATNPHDVLRILGQRAVQVHLVGEVQKVYNSQGVSIHDKHIEIIIRQMLRRVTIIESGDAELLPGELVERSKFETENRRVVTEGGHPASGRPQLMGITKASLATESWLSAASFQETTRVLTDAAINAKSDSLIGLKENVIIGKLIPAGTGLSRYRNIRVEPTEEAKAAMYSAVGYDDIDYSPFGTGSGQAVPLEDYDYGPYNQ
>NC_021177.1|WP_015610696.1|4923905_4927391_+|DNA-directed-RNA-polymerase-subunit-beta
MAASRNASTANTNNGASTAPLRISFAKIKEPLEVPNLLALQTESFDWLLGNAAWKARVEAALDSGQDVPTKSGLEEIFEEISPIEDFSGSMSLTFRDHRFEPPKNSIDECKERDFTFAAPLFVTAEFTNNETGEIKSQTVFMGDFPLMTNKGTFVINGTERVVVSQLVRSPGVYFDSSIDKTSDKDIFSAKIIPSRGAWLEMEIDKRDMVGVRIDRKRKQSVTVLLKALGWTTEQILEEFGEYESMRATLEKDHTQGQDDALLDIYRKLRPGEPPTREAAQTLLENLYFNPKRYDLAKVGRYKVNKKLGADEPLDAGVLTSDDVIATIKYLVKLHAGETETTGESGREIVVETDDIDHFGNRRLRNVGELIQNQVRTGLARMERVVRERMTTQDVEAITPQTLINIRPVVASIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSLASYGRVNAFGFIETPYRKVVDGQVTDEVDYITADEEDRFVIAQANAILSDELRFTEPRVLVRRRGGEVDYVPGTDVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMMRQAVPLIKSEAPLVGTGMEYRCATDAGDVLKAEKDGVVQEVSADYITVTNDDGTYTTYRIAKFMRSNQGTSVNQKVVVSEGDRVIAEQVLADGPATENGEMALGKNLLVAFMPWEGHNYEDAIILSQRLVQDDVLSSIHIEEHEVDARDTKLGPEEITRDIPNVSEEVLADLDERGIIRIGAEVVAGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGEIGKVIGVRVFDREEGDELPPGVNQLVRVYVAQKRKITDGDKLAGRHGNKGVISKILPIEDMPFLEDGTPVDIILNPLGVPSRMNPGQVLEIHLGWLASRGWDVSGLGDEWAKRLQSIGADQVPPGTNVATPVFDGAREDEISGLFQATIPNRDGDRLVQPSGKAQLYDGRSGEPFPEPVSVGFMYILKLHHLVDDKLHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYALQELLTIKSDDVTGRVKVYEAIVKGENIPEPGIPESFKVLIKEMQSLCLNVEVLSSDGMSIEMRDTDEDVFRAAEELGIDLSRREPSSVEEV
>NC_021177.1|WP_015610695.1|4922897_4923281_+|50S-ribosomal-protein-L7/L12
MAKLTQDELLAQFEELTLIELSEFVKAFEEKFDVTAAAAVAVAGPAGPGAVAEAAEEQDEFDVILTGAGEKKIQVIKTVRELTSLGLKEAKDLVDGTPKPVLEKVAKEVAEKAAESLKAAGASVEVK
>NC_021177.1|WP_007445921.1|4922255_4922813_+|50S-ribosomal-protein-L10
MARPDKAAAVAELTDQFRSSNAAVLTEYRGLTVAQLKELRRSLGENAQYAVVKNTLTKIAANEAGIDTLDDLFSGPTAVAFVTGDPVESAKGLRDFAKDNPNLIIKGGVLDGKALSADEIKKLADLESREVLLSKLAGAFKGKQTQAAQLFQALPSKFVRTAEALRAKKEEQGGAGTPAPAEAAE
>NC_021177.1|WP_015610694.1|4921066_4921969_+|hypothetical-protein
MRTSTLRRVGTGAAAAALMSVAACSGGGGDSGTAGKPAGTGGAAEADSVAALQQIREKTGTVRSARIEGTTEMGDTVSMQQTGTIGWADGLSGSLTITYTGGTMAEALKQGGGDGTVRARYLKDEYYANMGDAFAANVGGKHWVRYAYKDLAELGGPAGDVLEEQVQNSTPEQGVKALLAAGDVRRAGQEDVRGVSATRYSGTVDVAELTGRNSALDAEQLAALKEQLSAAGVTTQTVDIWVDRNDLLVKKTERGETAGGAFSSTVFYSDYGTKVSVEKPPAADTVDFKEILKQRGAGPS
>NC_021177.1|WP_015610693.1|4920161_4920884_+|50S-ribosomal-protein-L1
MKRSKNLRAADAKIDRERNYAPLEAVRIAKDTASTKFDSTVEVAFALGVDPRKADQMVRGTVNLPHGTGKTARVLVFATGDRAAAAEAAGADIVGADELIDEVAKGRLDFDAVVATPDLMGKVGRLGRVLGPRGLMPNPKTGTVTPDVVKAVNDIKGGKIEFRVDKHSNLHFIIGKTSFDETKLVENYAAALDEILRLKPSAAKGRYIKKATLATTMGPGIPLDANRTRNLLVEEDPAAV
>NC_021177.1|WP_015610701.1|4934908_4935625_-|hypothetical-protein
MAIIPTDLLDRIRALERQVRELMGSANTTPAQNSIVGGEVVIGERGRLRVRTAGDQDLVYLGRVAPDRDEETPQQGLVVRRDDGSLALTVWTGAPDPTAVQPVRILDRRGNVIVADDTVRGGLARPYIPYSLPAPADPTRWESTTATTWTTLHRGPGLVQHPRLHCRIAAEGGAGGEVRLLVDGDQVGPVGGPGAGLVLTERMAAEYGATVTFEIQARVTTPGTTIRCRPLTLYGLES
>NC_021177.1|WP_015610702.1|4935628_4936735_-|hypothetical-protein
MGRTAPEPVYRALFCDLRTDRLMDVLPLTETKFDDFIGKPGSLTATVPLPQGALAARARAALQPGRTAVWLERDGDIWWGGVLWTCTPVSDEQGRLTVQFQAGTFDSYLDHRILSQDLTVTGLDQFDIARTLVAHAQEQPGGDIGISLGHERSGIVRDHSHAYSALARIRELLDKLGQLNDGFEWRIHCYRDAGGMRVKRLQLGHPQIRTGHNDIVLDHPGPVLTYSLPTDSTVQANVWVARGESANTDQSQESEPLTVSEELPAELAQGWPRLELTSDHGGVSDAATLRSLARAELARQRRPEVIPELTVRLDGRITPALIGARIRLRVHDLWHHEGLDAQYRIVGMAVTPPQRAKQETAVLYLEGV
>NC_021177.1|WP_015610703.1|4936805_4938008_-|hypothetical-protein
MPVRSAWLINRTETESGQSRADTRLSPVGTMSPTGPLTSAGGVIPGSENGAYLMSALYVYGETAGMRATVAPGRAVIQGRGPAGAYPVVLTDYTDVGFDDGDAANPRIDVVVLRVHDAQFNSEDGRTEAALEVVKGKPEASPEPPALPDASLPLARVLVPAGASVGTGGIDWANAVYDLRVPTVAVGGILPESWNRDVLGGYVGQYRDTTTEFQRWDGVRWSGYPRQIGGIAPQGALARGEYTGQYRDEGGRLQRWDGTVWRPAVTASAWATNTDGGYCASTTWVEAVTDTVGPTITAAFTAPVSGAVFVSVGFMGHTAVEGQWSRMGVNIRKDGVLVVAADEIRSATVGSKAMTSVSATHRVTGLQPGAAYTAVSAYVTSATSSRGWFDNRFIRVDPVL
>NC_021177.1|WP_015610704.1|4938060_4939041_-|hypothetical-protein
MAETTTAYASAYETAPGSLITRDGQIQWAGLLMGPGTPYEIDRTGITGWDDLPTLDTGDVSRPDRHGAWPGAQWAQPRLVGATVWLLPRTVRDARGVAAGFRDATGADGGEDWLAVRLHGETLAVRARISRRVVPQDRTFVVHGASKASLQWTATDPRRFGSALREARTHLPVAEPGLLWPEEAGETGLGLQWPLDWGVPDPADPADGATGATGTCAAANGGSATAHPLIEFRGPVRRPTLTRLTDGRQLQYDIVLGPQDVLSVDTEAGTVLLNANASRLYTATPASAPEQLFGLVPGVTELAFRSDDTTPDPRASVTVRWRDAHW
>NC_021177.1|WP_015610705.1|4939087_4940371_-|hypothetical-protein
MSTAAIRTGTDPLAGTAGPLSAFRSGLGAAGSSLRTALRDIGRAQAAADGIRGGAASADPAVRQLRTGADAAGKSLAGTGRTAGLTATRLRTGSGKAHGAAAPLGALASGSSAFGGVAGILGKGTGTVSGLMGFFGGALTVGAGAMTAVNVAMRANPFGFVLGLIVPLAGLLIEYALSSQTGQKIMKQVFDQVLAVFRTIGKFLGPVVQAYATVVRAQFTAVRTVITAVVRGVGSALSTGFNGTRTAVTSATRAVTGLISGTWSGFRKAIQPTLDWITKRIPEMFTRVRDATSRTLHGMGDFVSTGMQGVMAAVTGPVKALISFANWVIDGLNKLSFSVLGKKFGVNLSKIPQLAEGGVVQPGGPGGASSVLPLSALSRLRPAEAGRASGRSAGPPERARLRTYHAAGRGGPLAVASDLLFLHGAAA
>NC_021177.1|WP_015610706.1|4940367_4941567_-|hypothetical-protein
MSLVQSLGRAGASLKGFKTQTESAARSAQGLGRSAQTGDRELKKIRSSAQSSARELTAIQRAADKAERSLAKAGTTGQKSGTQIGTFKSGADKASKGMNGLNKSMKGNIVGQLLSLLAPLIEKVVEMAARSKTMQKVLKVAFDAIRKVISTVMKAVGPIMSKAGALMKTVWNGIKKAVTVVILAVATVITTYFNAWRKLITTVMNAIRSVISSVWNGIRKVITPVVNWIRNTVPQAFSRVKERLSAVWGGLKDIAGRAFGRITGAVKGPVNSVIRLINSAIDKLNRIKVSIPGWVPGVGGKSFGISLPKIPQLAAGGIVQPRNGGVHAIVAEAGEAEAVLPLSKLDRLLRHTARRSRADSFNATAGAVSGFQIENYYEASSADLQETAAALLFLSKARG
>NC_021177.1|WP_015610707.1|4941644_4942397_-|hypothetical-protein
MTSPYPPGWPEGHTYEGIVKDVVAGLLSSGGDFTRTVKNLVLDTVTGEALEKIAVALGADPAADSINASSQTLYWSTQSFKFDPTLVTFAPDAVQITPKGIEIFGVNVTPGWEAKFERLIDWLTPWNIQAPDQTSGAGADVERGLKNTNIRVNGLEQRVGALRRIPATVGRHDTVLRGLTRNQRHMAASGATDTIRRSGAETRQANQLSGQRNQGANVRVHTFNANQLRETAQGLRRVEEEAARLERRLG
>NC_021177.1|WP_043973048.1|4942482_4942884_+|hypothetical-protein
MILLVALFSASALAAAAYGAYLAHLRWRQEMFIRSGRAEFAKGVCVNLRWTSGRLVASGIRYTDKQGRKHVAWTRSERTIPVAVGRTAEVQYDPEGKASALINGVADGTGSYGFAAGCFALSAILLFNGIRLI
>NC_021177.1|WP_043973050.1|4942890_4943238_-|hypothetical-protein
MDLLDWHRGRLTSRRLAVLVKHMPRDSAVSRELDGDGAEWTVTDYLLAAAVDHLAAANWMFASVNTDEDSDPPETPVPVPRPGDEALDTDTVSAREQRPAAHGGPDRAELMRFFV
>NC_021177.1|WP_015610710.1|4943303_4943594_-|hypothetical-protein
MASFDVNAARAQRLEVLGRTWSFDLDDDTFELPTELTRATATALRSLDDNDVDGLLRLLLGEEQFGRFAQHEITMQDIAALLEAYGKETGLGLGEG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021177_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_19

5063507-5063684

Orphan

Consensus_repeat	Method
GTACGCGCCGGTGTCGTAGGCGTCCGTCCCGTACGTG	PILER-CR

2 spacers

The CRISPR arrays of NC_021177_19

>merge|NC_021177|19|5063507-5063684|PILER-CR
GTACGCGCCGGTGTCGTAGGCGGCGCTGTCGTACGTGCCCGTGTCGTGTGCGCCGGTCTCGTGCGTACCGGTCCCGTAGGCGTCCGTCCCGTACGAGCCGTCGGTCACGTACGCGGTGCCCGTGCCGTAGGTGCCGGTGGGGTACGCGCCGGTGTCGTAGGCGTCCGTCCCGTACGTG

>NC_021177|19|2|5063507-5063684|PILER-CR
GTACGCGCCGGTGTCGTAGGCGGCGCTGTCGTACGTG	CCCGTGTCGTGTGCGCCGGTCTCGTGCGTA
CCGGTCCCGTAGGCGTCCGTCCCGTACGAGCCGTCGG	TCACGTACGCGGTGCCCGTGCCGTAGGTGCCGGTGGGGTACGCG
CCGGTGTCGTAGGCGTCCGTCCCGTACGTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_043974768.1\|5070655_5073022_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015610815.1\|5052266_5053616_-\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
NC_021177.1\|WP_015610829.1\|5073018_5074290_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|283431
NC_021177.1\|WP_015610830.1\|5075752_5076637_+\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NC_021177.1\|WP_164711333.1\|5055927_5056683_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_021177.1\|WP_032756336.1\|5064352_5065210_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224001
NC_021177.1\|WP_032756531.1\|5051600_5052110_+\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|311556
NC_021177.1\|WP_015610825.1\|5066077_5067718_-\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_007450903.1\|5074549_5075731_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NC_021177.1\|WP_015610821.1\|5059812_5062251_+\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
NC_021177.1\|WP_015610820.1\|5058170_5059370_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_021177.1\|WP_015610812.1\|5050209_5051478_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_106960136.1\|5067778_5069206_-\|SWIM-zinc-finger-family-protein	unknown	unknown	gnl\|CDD\|309540
NC_021177.1\|WP_031127381.1\|5069378_5070503_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|336785
NC_021177.1\|WP_015610817.1\|5055132_5055828_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_021177.1\|WP_032756343.1\|5053840_5055136_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|226951
NC_021177.1\|WP_031127384.1\|5065495_5065909_+\|cobalamin-B12-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|239022
NC_021177.1\|WP_015610811.1\|5049308_5050097_+\|class-II-aldolase/adducin-family-protein	unknown	unknown	gnl\|CDD\|235743
NC_021177.1\|WP_015610819.1\|5056728_5057826_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_021177.1\|WP_015610831.1\|5076764_5078042_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|132028

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015610830.1\|5075752_5076637_+\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NC_021177.1\|WP_015610815.1\|5052266_5053616_-\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	1.05985e-17
NC_021177.1\|WP_015610829.1\|5073018_5074290_+\|VWA-domain-containing-protein	gnl\|CDD\|283431	pfam05762, VWA_CoxE, VWA domain containing CoxE-like protein. This family is annotated by SMART as containing a VWA (von Willebrand factor type A) domain. The exact function of this family is unknown. It is found as part of a CO oxidising (Cox) system operon is several bacteria.	5.97026e-50
NC_021177.1\|WP_015610831.1\|5076764_5078042_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	4.51531e-14
NC_021177.1\|WP_164711333.1\|5055927_5056683_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.63239e-07
NC_021177.1\|WP_015610811.1\|5049308_5050097_+\|class-II-aldolase/adducin-family-protein	gnl\|CDD\|235743	PRK06208, PRK06208, class II aldolase/adducin family protein.	4.68553e-150
NC_021177.1\|WP_032756531.1\|5051600_5052110_+\|DoxX-family-protein	gnl\|CDD\|311556	pfam07681, DoxX, DoxX. These proteins appear to have some sequence similarity with pfam04173 but their function is unknown.	3.40777e-08
NC_021177.1\|WP_007450903.1\|5074549_5075731_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NC_021177.1\|WP_015610821.1\|5059812_5062251_+\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_021177.1\|WP_015610820.1\|5058170_5059370_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	9.62767e-31
NC_021177.1\|WP_106960136.1\|5067778_5069206_-\|SWIM-zinc-finger-family-protein	gnl\|CDD\|309540	pfam04434, SWIM, SWIM zinc finger. This domain is found in bacterial, archaeal and eukaryotic proteins. It is predicted to be organized into two N-terminal beta-strands and a C-terminal alpha helix, thus possibly adopting a fold similar to that of the C2H2 zinc finger (pfam00096). SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts.	6.74586e-05
NC_021177.1\|WP_031127381.1\|5069378_5070503_+\|AAA-family-ATPase	gnl\|CDD\|336785	pfam07728, AAA_5, AAA domain (dynein-related subfamily). This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.	3.59187e-42
NC_021177.1\|WP_015610817.1\|5055132_5055828_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.35589e-56
NC_021177.1\|WP_032756343.1\|5053840_5055136_+\|ATP-binding-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.04772e-18
NC_021177.1\|WP_031127384.1\|5065495_5065909_+\|cobalamin-B12-binding-domain-containing-protein	gnl\|CDD\|239022	cd02071, MM_CoA_mut_B12_BD, methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom with a group attached to a neighboring carbon atom. This family is present in both mammals and bacteria. Bacterial members are heterodimers and involved in the fermentation of pyruvate to propionate. Mammalian members are homodimers and responsible for the conversion of odd-chain fatty acids and branched-chain amino acids via propionyl CoA to succinyl CoA for further degradation.	8.83599e-66
NC_021177.1\|WP_032756336.1\|5064352_5065210_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	5.264e-24
NC_021177.1\|WP_015610819.1\|5056728_5057826_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.73309e-35

>NC_021177.1|WP_015610821.1|5059812_5062251_+|DNA-helicase-PcrA
MSSLFDDSFLAGLQSTEDGPPPPPEDHAPEAVPEGLFEGVYDAPPPPRDGYYRDGHPRPVIDAAALLDGLNTEQRAAVVHAGSPLLIVAGAGSGKTRVLTHRIAHLLAERGVHPGQILAITFTNKAAGEMKERVEELVGPRANAMWVMTFHSACVRILRRESKKLGFTSSFSIYDAADSKRLMALVCRDLDLDPKRYPPKSFTAKVSNLKNELIDEETFAGQAADGFEKTLAQAYALYQARLREANALDFDDIIMTTVHLLQAFPDVAEHYRRRFRHVLVDEYQDTNHAQYTLVRELVGPAGEADAPAELCVVGDADQSIYAFRGATIRNILQFEEDYSDAKTILLEQNYRSTQTILSAANAVIERNESRRPKNLWTNAGSGARIIGYVADTEHDEAQFVAEEIDRLTDKGDAKAGDVAVFYRTNAQSRVFEEIFIRVGLPYKVVGGVRFYERKEVRDVLAYLRVLANPEDTVPLRRILNVPKRGIGDRAEAMIDALSMREKISFPQALRRVDEAYGMAARSSNAVKRFNTLMEELRTIVESGAGPAVVLEAVLERTGYLAELQASTDPQDETRVENLQELAAVALEFEQERAEAEGTGTLAEFLEKVALVADSDQIPDEDEDGSGVITLMTLHTAKGLEFPVVFLTGMEDGVFPHMRALGQTKELEEERRLAYVGITRARERLYLTRAAMRSAWGQPSYNPPSRFLEEIPEAHLEWKRKGPMAAPAGPTSGITSSLSSSRARSGPSGFATRRSTEKPTVTLVVGDRVTHDQFGLGTVVAVEGIGDQAKATVDFGDERPKKLLLRYAPVEKL
>NC_021177.1|WP_015610820.1|5058170_5059370_-|C40-family-peptidase
MASHRKPRTKVRTTTPAVGFTTAALASVTLLSTQSATAAPAEPKPAIEDVQKKVDELYRQAGSATQQYNRAKSASTAQRTKVDTLLSDVAKRTEKINEARRELGAYAAEQYRTGGIAPTATFFLADDPQAYFDQSRLMSRSTERQQKAVDDFRTQQAAASKKRAEAVQSLEKLTETQTALRSSKQNVQTKLTEARSLLSKLTAEEKARLAELERKKEAEAKEKAEKLAARQAAEAKEREAAEKKAREEAAKESGGDSGSGSGSGTGTSPGTGTGTGTGAGGSYAAKAEKVLAFARAQIGKPYVWGAAGPSSYDCSGLTQAAWREAGVTLPRTTWDQVEVGTRVATSDLQPGDLVFFYDDISHVGIYKGDGMMIHAPKPGANVREESIYYMPIYGSVRPA
>NC_021177.1|WP_015610819.1|5056728_5057826_-|C40-family-peptidase
MAAHRKSAHRKPKQRPFTGPAARTAATLALAGAATATSATGAGAAPAEPAPTAAQVRAKVDRLYHDAEVATEKYNGAKEKEAAATKAVDTLADEAARRTDRLNTARHTLGSMATAQYRTGALDPAVQLALSSDPDTYLERAAQLDRAGDRQTSLLTGIRRQLSGIARVKARADRETEALAARRAELQEHRTAITTKLADARKLLATLTADERAAYERAADAAHGGGPAQADRSATHADRSTARASVAAPNSRAGRAVAFAHGAIGKPYVWGATGPNAFDCSGLTQAAWQAAGVSLPRTTYTQINAGQRVSRSELAPGDLVFFYSGISHVGLYIGGGQMIHAPRPGAPVRIAPIDQMPFAGATRVA
>NC_021177.1|WP_164711333.1|5055927_5056683_-|GNAT-family-N-acetyltransferase
MANAVQDYARTLTLRSPAHYRVGPFTVRHNPGWELKYANYAIPDRGAEPTADEVAALVEAFRARERLPRLEFLPDWAPAVEPALLAAGFTVENRAPLLACGREDLRTPKPVEGLRITVPSTEAEFTDTARVQHQGFGGEGEPEPGTTDWLRAAAAGDGVAALAVLDGAPAGAGGCSVAVDGLSELAGLAVAAPFRRRGVGAALTAWLTERALDQGCRTVWLEPGDPDVERIYAGVGYRRIGEKLNISLEPA
>NC_021177.1|WP_015610817.1|5055132_5055828_+|response-regulator-transcription-factor
MTENTEATGGPERRVRVVLVDDHRMFRTGVQAEIGRTEETGVEVVGEAADVDQAVTVITATRPEVVLLDVHLPGGGGVEVLRRCAPLMGAADNPVRFLALSVSDAAEDVIGVIRGGARGYVTKTITGTDLVDSVFRVQEGDAVFSPRLAGFVLDAFASTDAPPVDEDMDRLTQREREVLRLIARGYAYKEIAKQLFISVKTVESHVSAVLRKLQLSNRHELTRWATARRLV
>NC_021177.1|WP_032756343.1|5053840_5055136_+|ATP-binding-protein
MPAATARAASSLASDPEEPQPRKLYRSADGRMLGGVARGLAGHLGLPVAWVRFVFLGLFLSDGLGALLYAVFWIVVPLGVGGVGGAHAPRSVFETAADGRRRLRKPDPGQVFALVALLVGAGVFVANVDMGSEADRYIWPTLLIGAGSVLVWRQADNARRARWMEVGRRRRLLQLARALAGVALVGLGLAVFMVVRGSAAQLGNVLTAAIAVLTGIALLAGPYLVRMTQDLSEERLMRIRAQERAEVAAHVHDSVLHTLTLIQRNADDGGEVRRLARAQERELRNWLYNPEGTGKDEDDEPQTLAEAVKRAAAEVEDKHGVPLEVVVVGDCPLDDKLGAQMQAAREAMVNAAKYGGEGGAVQVFAEVEGRTVFVSVRDRGPGFDLDEVPADRMGVRESIIGRMQRNGGTARLRSVPGGGTEVELEMERASE
>NC_021177.1|WP_015610815.1|5052266_5053616_-|PspC-domain-containing-protein
MTAPSDAAPGVAPPDAPKPQLRRSPRQKVVAGVCGGLGRYCDVDPVIFRIVLGVLSVTGGIGLIFYGFAWLLLPLEGEEENEARRLLSGRVDGASLVALLLALIGCGLFLSMLGNRGMLAFAALLSVAVVGCSVWTQSRRTAAEEDPAAPGGAPAAAPAHPHTGGLGTPPPEVKAPPTPGGPSWWRDPIVKDGTTGPVGSGYLWGPPDTDVDAAQAKARAGRPSPDAPFRPPAPAAAAPGPRSIGGLVFLTALVAGGLGTGLSWEQQPLGTALQIGLVAALAVFGLGLLVSSLLGRTGFGTVLMAMVTAVLLAGATMLPKEIGTEWARQEWRPAEVSAVQQRYELGTGDARLDLSGVTVPPGESVRTRLEVGAGRAAVVVPKGVTVKVRAEAGLGEIRLEEGQRVQVRINSDQRSERTLPPPEGAKPAGTIELEAEVGVGQVEVSRAAS
>NC_021177.1|WP_032756531.1|5051600_5052110_+|DoxX-family-protein
MNGYGGGSYGLSEPRGLRERAREYALLPLRIFLGVTFVYAGLDKLTDSGFLSATGPGSIGEMMRGVRDSSAIPALVDLALKNPEGFGYAIAIGELLVGLGTLVGLWARLAALGGALISLSLWLTVSWQATPYYYGNDLPYLMAWLPLVLAGAAVFSADAFLASRRRRSM
>NC_021177.1|WP_015610812.1|5050209_5051478_+|hypothetical-protein
MALDEARASGTHGGGCTCGDCPHGAREGHRRAVAAFLAKRDELAAGNGLPAGVAQSASASRQWVSDELTESARTVAERGRAAGDVWLHHVWRGTLFAVWGAVIALLVGASLTAIGPGWTTARTAGLLAALVTAALLTVAARFHRARGGLLAPLIGEDNRLSTSRTVAAAWVLLAVFAVLVLALQLAGASDHEDRDALIQGLDLVRSAGVLTVLALVCAVAVVVRRVVTVRVLGRRLQKLRADRPRAADLLTDDSGRGSFTDVQYVLVSAVAVLFAGVRLARRPEQLPDLPWGLALLVAVSAATYFAGKYAEGGRPVVLSVVRAREAGDLDAPIRTGDDIEIRGAGFVPPGAGSPDRLARLVVRIGTVHVHVPLIPVAGGFANPTDTVLTVPVPVEVEPGTVDVQVVTAAGVETDRCSIDVTD
>NC_021177.1|WP_015610811.1|5049308_5050097_+|class-II-aldolase/adducin-family-protein
MSEPPAVPAPAPIPVEQLHFSMPPVHASPDEERAYRRQRLAGALRLFGEYGYEDGVSGHITVRDPELADCYWVNPFGAPFAGIAPQDLILVNGDGQVVQGRFHVNQAAFAVHAAVHRARPGAVAVAHTHSVHGRALAALGELIEPITQEACAFYEDHALYDAYTGVVVDEEEGRRIAEVLGERKAVILRNHGLLTVGDSVDAAAWWFLTMERACQVQLLARGAGKPVLIDHRDAVTTRDQLGSDLVAWINYQPLWQRISRTF
>NC_021177.1|WP_032756336.1|5064352_5065210_-|alpha/beta-fold-hydrolase
MKALPFLSLLPRLPGPRFPAALLGATVLELVVLTGHLVAYPFGLTQERRTPGPPPGTPPGTRPSPLPGSPAAERPVVLLHGFIDNRSVFVLLRRALARHGRRHLASLNYSPLTRDLRTAAELLGRHVEEICARTGQREVDIVGHSLGGLIARYYVQRLGGDRRVRTLVTLGTPHGGTAVAPGAGIHPIVRQMRGGSALIEELRLPAPGCRTRFVSFWSELDQVMVPVGTACVDHPDLDAVNVRVTGIGHLALPVHPAVAAAVREALETQETREGTVPSTGTTSVA
>NC_021177.1|WP_031127384.1|5065495_5065909_+|cobalamin-B12-binding-domain-containing-protein
MGVTGPIRVVVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLHQTPEQIVDTAIQEDADAIGLSILSGAHNTLFAKVIELLKEREAEDIKVFGGGIIPEDDIAPLKKLGVAELFTPGATTTEIVTWVNANVRQPAQT
>NC_021177.1|WP_015610825.1|5066077_5067718_-|hypothetical-protein
MPRTTTGPTADRPLAALPWEELVTSALLGTDRRPPVAPGGRVPADGPAALLDAVALHTVRRRAGLLPAVPGARPEPTPHDPRPQLPEAARHRLAQLLADRAAPTASGRRGAAPDLTELIPQWLATANRRGFRAPAALVPPLLDAARARTDLRPQALAFAGPLGLWLAALNPEWKFALRGSAGGSLVPDTSDPEAVRRLWEEGLFAERIALLDAVRAREPGAALALLTTVWSTERAEDRLMFLDSLRTGLGDGDEEFLEQALADRSRNVRATAAELLSALPSSAFAGRMAARATSCVNPDRTGAGAGAGASIAVEAPHECDAGMQRDGVAAVPPTGRGERSWWLVQLVEATPLGVWQEQFGGRPAEEIVALPVADDWAGELHAAWCRAAVRQRHPEWARALLGAASAPPAGSPGPASIAERSKLLAVLSEAERADWVAAFIAAHGLSEAFQLLGVCTVPWAGPLGRAVVDALDIARDGGSYPWSFSGVMGLAERCLDPAEADRLEVLTATPDEQEDASPGAGGYWSEAFQRLVSTLRLRAAMEAELT
>NC_021177.1|WP_106960136.1|5067778_5069206_-|SWIM-zinc-finger-family-protein
MLLSHGGEPLPATESVARWTVEQVLSLAPDDASRKAGNKLASAGLWSGTGFDGSGAVWGLCRGSGSKPYQTVVDTTGPAYRCSCPSRKFPCKHALGLLLLRASGDGPVQQGEPADWAAQWLEARRGRVEAKQAKQEAVASGESAAGPADSAAARKRAERRAERVTSGAQELEQRLTDLLRGGLATADRAGYTLWEETAARMVDAQAPGLASRVRELGAIPGSGPGWPVRLLEECGLLHLLDTAWLGREALPDQLAATVRTRVGLPMSAEGPPVRDHWLVLAQYDTPDGRLVTRRIWLYGRESGRTALLLSFGPMGRAPELALPVGVTIDAELTPYPGGGLRADLGRQFATPGPVPGTPPPGGSTATALAVHADALRGDPWLDAWPVTLRDVIPVPSGGGWQLADAESESALPLAPAALSRPGLWKLVALSGGGPVTAFGELGHRGFDPFAAWDTGAGRGGGSGSGGATNGTVRLI
>NC_021177.1|WP_031127381.1|5069378_5070503_+|AAA-family-ATPase
MTVPETTAAVDGATGPEALRPHAEDAFADELKALAAADDRPRPARWRLSPWAVATYLQGGTLPDGTVITPKYVGPRRLIEVAVTTLATDRALLLLGVPGTAKTWVSEHLAAAVSGDSTLLVQGTAGTPEEAVRYGWNYARLLAQGPSREALVPSPLMRAMSEGMTARVEELTRIPADVQDSLITILSEKTLPIPELGQEVQAVRGFNVIATANDRDRGVNELSSALRRRFNTVVLPLPATPDAEVDIVSRRVDQIGRSLDLPAAPEGLSEIRRVVTVFRELRDGVTTDGRTKLKSPSGTLSTAEAISVVTNGLALAAHFGDGILRPADVAAGILGAVVRDPAADRVVWQEYLETVVRERDGWKDFYRACREASV
>NC_021177.1|WP_043974768.1|5070655_5073022_+|hypothetical-protein
MSFAGPLLLGVRHHGPGSARAVLAALDAARPAAVLIEGPPEGDALLPLAADPQMRPPVALLAHAVDDPGRAAFWPLAEFSPEWVAIRWALAHDIPVRFIDLPATHSLALKEPQREAPTEESGPAPVSAEDGDRDRDEVTPGVDPIRVLAETAGYDDPERWWEDVVEHRSPDGSSTTGAAADALAPFTALAEAMTVLREAYGDGGQPRDAVREAYMRIQLRTARKEFGDGVAVVCGAWHVPALAARTTLAADRALLKGLPKVKTEMTWVPWTHRRLARHSGYGAGIDSPGWYGHLFGAADRPIERWMTKVAGLLREEDRFVSTAHVIEAVRLAETLAAMRGRPLAGLSETTDAVRAVMCEGSDVPLALIQDRLVVGETLGEVPDSAPAVPLQRDLTRSQRTLRLKPEALERELDLDLRKETDAAKSRLLHRLRLLSIGWGEPAESQSRSTGTFRESWRLRWEPELHVRVAEAGVWGTTVETAATAKAESGALAATALSEVTALAEHCLLAGLPDALPVVMKALADRAALDADVGHLADALPALARSLRYGDVRSTDTAALAEVAAGLAERICVGLPPACTGLDTDGAEALRRQVDGVHSAIGLVVAGAATAEGLRDRWGAVLRKLAGRDTVAGIIRGRATRLLLDEGRLTEDEAARLMGLALSPGTPPTDAAAWIEGFVGGASGGGMLLVHDDRLLSLVDTWLTGVPADTFTDVLPLLRRTFSAYEPGVRRTLGELVRRGPVPEGAGNDGMDHTYPGFGPGLDPGRADAVEPVLHLLLGRTPEPAEATA
>NC_021177.1|WP_015610829.1|5073018_5074290_+|VWA-domain-containing-protein
MTAHVPQHATQDDDETGETVDTETTRARPTDGERMRRWRMVLGADSAESTGCTLTGQDAAMDGALDALYGGGGKKPGGRGGGGRSAGLGASAPSVARWLGDIRTYFPSSVVQVMQRDAIDRLGLSALLLEPEMLEAVEADVHLVGTLLSLNKAMPETTKETARAVVRKVVDDLEKRLESRTRATLTGALDRSARISRPRHRDIDWDRTIRANLKNYLTVPGADGEEATGTVVPERLIGYGRASQSVKKDVILCIDQSGSMAASVVYASVFGAVLASMRALATRLVVFDTAVVDLTDQLDDPVDVLFGTQLGGGTDINRALAYCQSKITRPADTVVVLISDLYEGGIRDEMLKRVAAMKASGVQFVTLLALSDEGAPAYDHEHAAALGALGAPAFACTPDLFPDIMAAAIEKRPLPIPDKEAQP
>NC_021177.1|WP_007450903.1|5074549_5075731_+|ADP-forming-succinate--CoA-ligase-subunit-beta
MDLFEYQARDLFAKHGVPVLAGEVIDTPEAAREATEKLGGKSVVKAQVKVGGRGKAGGVKLAADPDEAVARATDILGMDIKGHTVHKVMIAELSPEIEAEYYVSYLLDRTNRTFLAMASVQGGMDIEEVAEKTPEALAKVPVNAVDGVDIVKAREIVAQAKFPADVAEGVAEALVTLWDTFVAEDALLVEVNPLVKTKDGRILALDGKVSLDENADFRQPGHEALEDKAAANPLEAAAKAKNLNYVKLDGEVGIIGNGAGLVMSTLDVVAYAGENHGNVKPANFLDIGGGASAEVMANGLEIILGDPDVKSVFVNVFGGITACDEVANGIVQALALLESKGEKVEKPLVVRLDGNNAELGRKILSDANHPLVQRVDTMDGAADKAAELAAAAK
>NC_021177.1|WP_015610830.1|5075752_5076637_+|succinate--CoA-ligase-subunit-alpha
MAIFLTKDSKVIVQGMTGATGMKHTKLMLADGTNIVGGVNPRKAGTSVDFDGTEVPVFGSVAEAIEKTGANVSVLFVPPAFSKAAVVEAIDAEIPLAVVITEGIAVHDSAAFWAYAGAKGNKTRIIGPNCPGLITPGQSNAGIIPGDITKPGRIGLVSKSGTLTYQMMYELRDIGFSSAVGIGGDPVIGTTHIDALAAFEADPDTDLIVMIGEIGGDAEERAADFIAKNVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPTETAKLAREILGA
>NC_021177.1|WP_015610831.1|5076764_5078042_-|helix-turn-helix-domain-containing-protein
MTRSTTDEAAAPPLPSPKERRRLREAKSLSEEQVAEAVGVTRATVRSWETGRTSPRGRKRALYAKLIAPDPEPVPATRPKAVRRKERPERPAPAAEPVSVAPTPAAVAPAAVAPTSAREPVPTGSPEPEPAPTRSPVPASASAPPEAEPAVPRLSPDEAFDALYAHSAPGLVRQTYLLTGRRSLARESVERAFQLAWHRWPEVAVDRDPVGWVRAAAYEYAMSPWHRLRRVHRHPDAPPSEPARRALFEALLDLPPAYRRTLLLYDGVGLDLPETAAETEASTPAAAGRLEVARAAVAERLPELAAAASPAEQSELLQDRLGGLARAEHVPAPSPARTVRTGSEDKARLWTRAAIAFVALLIGATALTLHTAPTHYEQPVSPPERVGGVPPRGGPQKLTPQDLKLQKVLKEQLAHGPERLVPRIP

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Crispr_ID: NC_021177_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_20

6027819-6028006

Orphan

Consensus_repeat	Method
CGTACTGCTCCTGGCCGTAG	CRT

3 spacers

The CRISPR arrays of NC_021177_20

>merge|NC_021177|20|6027819-6028006|CRT
CGTACTGCTGCTCGTAGGAGCCGGCGTACGGGGCCTGGCCCTGCTGGGCGGAGTCCTGGCCGTACTGCTCCTGGCCGTAGGAATCCTGCGCGTAGTTCTGCGAGCCGTCGTACTGCTCCTGGCCCTGCGCGCCGTTGTACGGGGCCTGCCCGGCGTACGGCTCCTGCGCGTACTGCTCCTGGCCGTAG

>NC_021177|20|1|6027819-6028006|CRT
CGTACTGCTGCTCGTAGGAG	CCGGCGTACGGGGCCTGGCCCTGCTGGGCGGAGTCCTGGC
CGTACTGCTCCTGGCCGTAG	GAATCCTGCGCGTAGTTCTGCGAGCCGT
CGTACTGCTCCTGGCCCTGC	GCGCCGTTGTACGGGGCCTGCCCGGCGTACGGCTCCTGCG
CGTACTGCTCCTGGCCGTAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_043974868.1\|6016837_6017500_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NC_021177.1\|WP_015611641.1\|6037625_6039098_+\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NC_021177.1\|WP_015611629.1\|6017667_6018894_-\|secreted-sugar-hydrolase	unknown	unknown	gnl\|CDD\|185759
NC_021177.1\|WP_015611630.1\|6019265_6023138_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372376
NC_021177.1\|WP_015611637.1\|6031300_6031708_-\|DUF742-domain-containing-protein	unknown	unknown	gnl\|CDD\|283084
NC_021177.1\|WP_043973482.1\|6039194_6039914_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NC_021177.1\|WP_015611626.1\|6015391_6016018_-\|YceI-family-protein	unknown	unknown	gnl\|CDD\|377274
NC_021177.1\|WP_003966003.1\|6040676_6041393_-\|IclR-family-transcriptional-regulator-NdgR	unknown	unknown	gnl\|CDD\|224332
NC_021177.1\|WP_015611634.1\|6025910_6026567_-\|DUF742-domain-containing-protein	unknown	unknown	gnl\|CDD\|283084
NC_021177.1\|WP_006127850.1\|6031843_6032257_-\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|367422
NC_021177.1\|WP_015611640.1\|6036847_6037633_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NC_021177.1\|WP_015611636.1\|6030738_6031320_-\|ATP/GTP-binding-protein	unknown	unknown	gnl\|CDD\|225138
NC_021177.1\|WP_015611643.1\|6041566_6042994_+\|3-isopropylmalate-dehydratase-large-subunit	unknown	unknown	gnl\|CDD\|235490
NC_021177.1\|WP_015611639.1\|6036570_6036753_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015611632.1\|6025057_6025261_+\|acyl-CoA-carboxylase-subunit-epsilon	unknown	unknown	gnl\|CDD\|379386
NC_021177.1\|WP_015611631.1\|6023401_6024985_+\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NC_021177.1\|WP_043973480.1\|6032266_6035992_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|377989
NC_021177.1\|WP_015611627.1\|6016288_6016813_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_014048542.1\|6025348_6025930_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|225138
NC_021177.1\|WP_030125847.1\|6026657_6027071_-\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|214939

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_043974868.1\|6016837_6017500_-\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	4.14592e-05
NC_021177.1\|WP_015611641.1\|6037625_6039098_+\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NC_021177.1\|WP_015611629.1\|6017667_6018894_-\|secreted-sugar-hydrolase	gnl\|CDD\|185759	cd09220, GH64-GluB-like, glycoside hydrolase family 64: beta-1,3-glucanase B (GluB)-like. This subfamily is represented by GluB, beta-1,3-glucanase B , from Lysobacter enzymogenes Strain N4-7 and related bacterial and ascomycete proteins. GluB is a member of the glycoside hydrolase family 64 (GH64) involved in the cleavage of long-chain polysaccharide beta-1,3-glucans, into specific pentasaccharide oligomers. Among bacteria, many beta-1,3-glucanases are implicated in fungal cell wall degradation. GluB possesses the conserved Glu and Asp residues required to cleave substrate beta-1,3-glucans. Recombinant GluB demonstrated higher relative activity toward the branched-chain beta-1,3 glucan substrate zymosan A than toward linear beta-1,3 glucan substrates. Based on the structure of laminaripentaose-producing, beta-1,3-glucanase (LPHase) of Streptomyces matensis, which belongs to the same family as GluB but to a different subfamily, this cd is a two-domain model. Sometimes these two domains are found associated with other domains such as in the Catenulispora acidiphila DSM 44928 carbohydrate binding family 6 protein in which they are positioned N-terminal of a carbohydrate binding module, family 6 (CBM_6) domain.	6.67668e-176
NC_021177.1\|WP_015611630.1\|6019265_6023138_+\|hypothetical-protein	gnl\|CDD\|372376	pfam12905, Glyco_hydro_101, Endo-alpha-N-acetylgalactosaminidase. Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolize the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Endo-alpha-N-acetylgalactosaminidase, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor.	2.98466e-156
NC_021177.1\|WP_043973482.1\|6039194_6039914_+\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	5.42786e-36
NC_021177.1\|WP_015611626.1\|6015391_6016018_-\|YceI-family-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	1.17676e-61
NC_021177.1\|WP_003966003.1\|6040676_6041393_-\|IclR-family-transcriptional-regulator-NdgR	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	6.38332e-45
NC_021177.1\|WP_015611637.1\|6031300_6031708_-\|DUF742-domain-containing-protein	gnl\|CDD\|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	6.47098e-41
NC_021177.1\|WP_015611634.1\|6025910_6026567_-\|DUF742-domain-containing-protein	gnl\|CDD\|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	2.38919e-44
NC_021177.1\|WP_015611640.1\|6036847_6037633_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.20866e-100
NC_021177.1\|WP_015611636.1\|6030738_6031320_-\|ATP/GTP-binding-protein	gnl\|CDD\|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	1.81456e-45
NC_021177.1\|WP_015611643.1\|6041566_6042994_+\|3-isopropylmalate-dehydratase-large-subunit	gnl\|CDD\|235490	PRK05478, PRK05478, 3-isopropylmalate dehydratase large subunit.	0
NC_021177.1\|WP_015611632.1\|6025057_6025261_+\|acyl-CoA-carboxylase-subunit-epsilon	gnl\|CDD\|379386	pfam13822, ACC_epsilon, Acyl-CoA carboxylase epsilon subunit. This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes.	7.20254e-10
NC_021177.1\|WP_006127850.1\|6031843_6032257_-\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	3.21424e-22
NC_021177.1\|WP_015611631.1\|6023401_6024985_+\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NC_021177.1\|WP_043973480.1\|6032266_6035992_-\|sensor-histidine-kinase	gnl\|CDD\|377989	pfam08376, NIT, Nitrate and nitrite sensing. The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations. The NIT domain is predicted to be all alpha-helical in structure.	9.36085e-39
NC_021177.1\|WP_014048542.1\|6025348_6025930_-\|ATP-binding-protein	gnl\|CDD\|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	4.342e-45
NC_021177.1\|WP_030125847.1\|6026657_6027071_-\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|214939	smart00960, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	4.71182e-22

>NC_021177.1|WP_030125847.1|6026657_6027071_-|roadblock/LC7-domain-containing-protein
MSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSEGFPRDRADQLAAVASGLTSLTAGASRIFEGGAVNQTVVEMERGFLFLMSISDGSSLAVLAHPDADIGLVGYEMALLVDRAGSVLTPDLRAELQGSLLN
>NC_021177.1|WP_015611634.1|6025910_6026567_-|DUF742-domain-containing-protein
MAAPTGGHPYEGEQRVPGEHGDNRFGYPAGSGGQAPGNAYQPYQQPQQSQGAHGSQGSEWPQQQPGSPWPQQQPQQSQRYDAHQQQRIQPVQQQRRAPEPAKPAAHNPLVRPYAMTGGRTRPRYQLAIEALVSTTADPSRLQGQLPEHQRICRLCIEIKSVAEVSALLSIPLGVARILVADLAEAGLVAIHQPGGDEAAGGQPDVTLLERVLSGLRKL
>NC_021177.1|WP_014048542.1|6025348_6025930_-|ATP-binding-protein
MDFASSSGGAARSTTSAKIVVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHTGDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLVDTRRLADCFPAVDYFENSGLPFVIALNGFDGHQPYTPDEVREALQIGPDTPILTTDARHRADAKSALITLVEHALMARLR
>NC_021177.1|WP_015611632.1|6025057_6025261_+|acyl-CoA-carboxylase-subunit-epsilon
MSLTSAESVLRVEKGHADPEELAAITAVLMARAAAQPATAAHRGRDTAGWRRLERTPGFRAPHSWQG
>NC_021177.1|WP_015611631.1|6023401_6024985_+|acyl-CoA-carboxylase-subunit-beta
MTVVDETQGEPSDTRGRVAELLALREQARRGPSERATQAQHAKGKLTARERIELLLDPGSFREVEQLRRHRATGFGLEAKKPYTDGVITGWGTVEGRTVFVYAHDFRIFGGALGEAHATKIHKIMDMAISAGAPLVSLNDGAGARIQEGVSALAGYGGIFQRNTRASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRETSQMFITGPDVVKAVTGEEITQNGLGGADVHAETSGVAHFAYDDEETCIAEVRYLIGMLPSNNRENPPTVESDDPADRRGDVLLDLVPADGNRPYDMHQVIEELVDDGDYLEIHERWARNIICAMARLDGQVVGIVANQPQALAGVLDIEASEKAARFVQMCDAFNIPIITLLDVPGFLPGVDQEHGGIIRHGAKLLYAYCNATVPRISLILRKAYGGAYIVMDSQSIGADLTYAWPTNEIAVMGAEGAANVIFRRQIADAEDPEAMRARMVKEYKAELMHPYYAAERGLVDDVIDPAETREVLIASLAMLRNKHADLPSRKHGNPPQ
>NC_021177.1|WP_015611630.1|6019265_6023138_+|hypothetical-protein
MSPRFPSAGLVAVASAAVLALVGTALPAAAADPSPAPAGAAKPSGSATIGSPQLTVAVGDDFPRVLSYTDRASGKRLLGSTRPVTAVTLNGTAHPVKLKGAPKTNGSSARYTLVFTDLPGVEIDASLTVSGRTTTFKVTAVRDTAAFRVGTIDIPGHDLISVGSTEPGAATAFTTLDPDSTRTADVFAKVTGDTKPDPAPVGATYAILSTSSLAAAVESNSSYDKPSGPTGGDDARFWRQARTEADGAVRVGVGSGQWTYRGEGAPKPESGENLPWAKVVVTPDANGDKAVDWQDGAIAFRSIGITAPGSDETADRVVTHIPFNFASQATHPFLRTLDDVKRISQATDGLGQLAVLKGYGSEGHDSAHPDYGGNYNKRAGGLKDLNTLLKDGKKWGADFGVHVNATESYPEANAFSEQLVDRTKPGWNWLNQSYYIDQRRDINSGDLAKRFQQLRDETDKNLDFLYIDVYYSHGWIADKTIQAVQKQGWTVGTEWADKFERASLWSHWANDLNYGGATNKGLNSQIIRFIRNGEKDIWNNHPVLGQSVLEDFEGWTGETDWNAFTANIWQRNLPAKYLQQQKITRWDGNDITFTGGVRGTVEDGKRTFYDEGRKVLSGTDYLLPWDGGKKLYHYSETGGTSTWEVPGKGPYTVYELSDNGREKVATVRPDADGRITLTATAGQPYVLYPDRAPKKAPVAWGQGTPLKDPGFNDRALTGWTKTGTAARDTDEQGRNSAALSGTAEAALSQSVTGLKPGKRYTASALIEVEPGATRRTVLSAGGKSVAVDRSTAEDFVAASDWHGTSFQRAKVNFTAPANGRTTLRIEAAAGSTARVRADDVRIVENAPATRPGTLVYEDFEAVDQGWGPFLKGNAGGSTDPRTSVSQLNAPYTQSGWNGKLIDDVLGGKESLKSHEENTGLVYRTAPWTVPMKDGHRYEVEFDYQSSHAGAYSWVDGYDRVAGGKASSTETRATPIGQQRTTGHFSQTLTAGCGDTWTGLRKRAGAPEGADFVLDGFTVTDLGPAPAGQEAVCGTLGVAADAETLEPGAPNTVEATFGNDETSAATGVKLALTVPEGWQAEPAGAVAFDSVAPGAKVTGSWRVTPPVDAPYETYQLGAEATYAVSGSPRTLGAQTSVRTLPPPPTEDSWASDLDWTASQNGWGPVERDQSNGETGTGDGSPLKIGGVAYAKGIGTHAPAKIRYYLGGKCTSLTAEVGVDDVQATRGSVRFSVTADGTEKVKSPVLGAADPAWKLTADVTGARYVELVVDDGGDGNGNDHADWGNARFHCGG
>NC_021177.1|WP_015611629.1|6017667_6018894_-|secreted-sugar-hydrolase
MISRRMFLTGAAASAAALTYPAWGTALSPRASAAPATCELALENKSLPGTVHAYVTGHELGTDRWVLLKPDGGVYRPDSPGAPQTPLPVDCAIPLNGAGAGPVLLTLPQMYGARVYFVRDDKLDFFLNPGPSLVEPAFATPTDPNYGRTWAFAEFTFNTEQLYSNISYVDLITALPIGITLEGDGTHVVAPHPEGAVDRIAADLTAQAAADGQPWDKLITRGDDGKVLRVVSPQNIMAPYFDRPAEMPFRDLFTAQIDEVWEKYRSEDLRIDLQGGRGTLAGRVSGDTLTFEGGHTFTKPETKDIFTCNHGPFTNNPGDSDDKKAILARLAAGFNRSIMLSHPSQPNGTSVADYYRTPVTNHWSRVVHANSPIGYAFPYDDVRPDGEPDVSGAAHDGNPRRFTVSVGS
>NC_021177.1|WP_043974868.1|6016837_6017500_-|peptidoglycan-binding-protein
MRMRKNRLPRRTLAVLGAVFLLTAPTAAHATAPPPPTAQGLRAFQQSYGLDPTGRVDTATAQLLGSAPDSELRTVFADPSDLGPEQLAHARTVIGVGKGARIPEQGQVIALMTAMQESTFVNYTTPVDNDSLGIFQQRPSNGWGTAKQITHVPTASKSFYGLPSPTKNPGLLQIEGWESMEPGEACQAVQRSAHPGRYAQWERFARDLLEREGPTVDPID
>NC_021177.1|WP_015611627.1|6016288_6016813_+|hypothetical-protein
MVNRPRLRSALTALALVLGALFVPGIGALGSGATEAHAVTKLTHAQATSRFSSSGITWSSSGGCSNRNVPTCTSFDQLNLPSAQGAQTLRSATGCALRITGGTETGHAGGTYSHWNGYKLDFAKSACLNNYVTGVFTYIGVRGDGARQYQSGSGNIYADEGNHWDVTYYNCGGC
>NC_021177.1|WP_015611626.1|6015391_6016018_-|YceI-family-protein
MALFNRKSTAATPTAVIEAPAVDPALAALTGTYTIDPAHSSIGFTVRHAMVTNVRGSFGEHEGTLTLDGSDPANSSAAIDVKIASVDTGIGDRDGHLVSGDFFDAEKFPLMTFRSTRAEQLGGDAYRITGDLTIKDVTRPLSIDLEFNGSATDVYGNERVGFEGSADILRSDWGLTWNAALETGGVMVSDKVKLTFDISAIKAAAPQA
>NC_021177.1|WP_015611636.1|6030738_6031320_-|ATP/GTP-binding-protein
MDFASSSGGTARATTSAKIVVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHTGDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLVDTRRLADCFPAVDYFENSGLPFVIALNGFDGHQPYTPDEVREALQIGPDAPIITTDARHRADAKSGLITLVEHALMARLK
>NC_021177.1|WP_015611637.1|6031300_6031708_-|DUF742-domain-containing-protein
MTPPPASPDPYGALHHASYDEGGDQPLVRPYAMTGGRTRPRYQLAIEALVSTTADPAHLGTLLPEHQRICHLCREVKSVAEVSALLSMPLGVARILVADLAEAGMVAIHQPGNGEAGGAPDVTLLERVLSGLRKL
>NC_021177.1|WP_006127850.1|6031843_6032257_-|roadblock/LC7-domain-containing-protein
MSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSEGFPRDRADQLAAVASGLTSLTAGASRIFEGGAVSQTVVEMERGFLFLMSISDGSSLAVLAHPDADIGLVGYEMALLVDRAGTVLTPDLRAELQGSLLH
>NC_021177.1|WP_043973480.1|6032266_6035992_-|sensor-histidine-kinase
MQGRFKRDGSAPAEQEPRGGTDRGSSPQHAQNPGPAAAGDNGDRAQRPASTTSSGAEPGTPPASRGPVDTGSRIALRNWRISTRLVSLLALPVVAATSLGGLRINESMTDMQQLEHMQLLTQMTKQATSLAQALQVERDQSAGPLSNGSKATDYKVSQPREKTDRAKDSFLDATNEIGDFENDDALESIHASVAQIASQLGDIRSIRKSAYEDGAPSLNTIDQYSQLITSLLSLSQDMAQATSNPDMIKRTRALAAFSSAKEYASIQRAVIAAALPGGSVKEPHLNENDKQFGSNALDKETRAISSFKSIYGSTGESAVDLMAPLDNGNNPEINAANMYAKHILDTPNGIDGAKVRSYMDWYDQSSTKIDAMKTIETTLLSDMEAKARELREASQREAIINGAVILLVLGVSLVGAFVVARSMIRSLRRLQDTATRVAQDRLPELVKQLSETDPQDVDTSVESVGVHSRDEIGQVAAAFDDVHREAVRLAAEQALLRGNVNAMFTNLSRRSQGLIQRQLSLISELESREADPDQLSSLFKLDHLATRMRRNGENLLVLAGEEPGRRWTRPVPLVDVLRAAASEVEQYERIELSAVPATEVAGRVVNDLVHLLAELLENATSFSSPQTKVRVTGHALPDGRVLVEIHDTGIGLSPEDLAAINERLAQPPTVDVSVSRRMGLFVVGRLSLRHGIRIQLRPSDSGGTTALVMLPVDVAHGGKQPPSKQGAGQQPGGAPGGLLAGGNGNGAGNGQRPGLGGGPGGPGAKSLGSAPGGQRGQVGAGSGPRAALPARDNGPGRPQNNGPQGPGNPNQGGQPFPGQEPQRQGGGGLSGAFGNGARLGARGQGDAPGRTEPGQPNLFGHGAPASPGQNGRSNAFAPQNQQGQQGQQGRPGQPQYQQGPGAPQARHEQNGPGTQGGFQQPGGPGRQLPPTGGPRAELPGGNAQQRPQAAGWGADGPRGHEEHETTGQFARPTGNGQDPAFNAPLNQRPADGHQDPAATSQFARPDFDAPQGQGYGQQAQDPASTAQFARPDFNAPLQQNQGPGLPAPRQRGRDGNDFGAPRPPAGEPPYRPALPQQPEALPPAGPGDGRTPLYDTLETNWFHGPGQGGQQAPEPQAPAAPEPTGVPVPPMPQRGAAEPPVTSSWRASPNDELVRQAERVKKPAAGGVTTSGLPRRVPRANLVPGTAQQQNHQSGPQVSRAPDDVRGRLTNLRRGIQQGRQANNGPSTGSIHLGPTHQQER
>NC_021177.1|WP_015611639.1|6036570_6036753_+|hypothetical-protein
MKTTTMFRNIANPRRTTLAHLKDAEALQTPLLPEHAADLPTVTANPRRTILMEAPVAAAQ
>NC_021177.1|WP_015611640.1|6036847_6037633_+|fumarylacetoacetate-hydrolase-family-protein
MRIARFSIDGNVAFGAVEGQGTVESGDLVLDIIKGIPYADFELSGTKVPLNKVRLLPPVLPNKVVAIGRNYAEHAAELGHEVPDAPITFFKPTTSVIGSGDAIEYPSFSNDLHHEAELAVVIGRMCREVPRERVKDVILGYTCANDVTARDVQEREKQWARAKGFDTSCPLGPWVETDLDPHDLTIQATVNGEQRQLGRTSDMVRSIEDLIVHITEAMTLLPGDVILTGTPAGVGPLHVGDEVAVTIEGIGTLTNKVIKRG
>NC_021177.1|WP_015611641.1|6037625_6039098_+|glutamate--tRNA-ligase
MANAPVRVRFCPSPTGNPHVGLVRTALFNWAFARHHQGTLVFRIEDTDAARDSEESYQQLLDSMRWLGLDWDEGPEIGGPHAPYRQSQRMDLYKDVAEKLLAAGYAYPCYCTTEELDTRRDAARAAGKPSGYDGHCRDLTAEQKAAYEAEGRSSIVRFRMPDEAITFTDLVRGDITVQPENVPDYGIVRANGAPLYTLVNPVDDALMEITHVLRGEDLLSSTPRQIALYRALIELGIAKETPAFGHLPYVMGEGNKKLSKRDPQASLNLYRERGFLPEGLLNYLSLLGWSIAEDRDIFSTDELIAAFDIKDVNANPARFDLKKCEHINAEHIRMLDVKAFTEACGPWLKAPFAPWAPEAFDEDKWAEIAPYAQTRVTVLSDITANVDFLFLDEPVHDEASWTKAMKEGSHALLTTARANLAAADWNAEALKNAVLTAGEAHGLKLGKAQAPVRVAVTGRTIGLPLFESLEILGRDKSLARVDAALAKLTA
>NC_021177.1|WP_043973482.1|6039194_6039914_+|HAD-family-hydrolase
MPIRAVLWDIDDTIFDYAGADHTGMRLHLESVGLPEAYASADEALDAWKTITIRHWARVAAGETDFLGQRRDRVREFLSRAMTDTEADDWFAGHVTHYESAWALFPDVLPVLDRLVPDYRHAILSNSSTGHQHRKLTALGIRDRFEAMVCAVELGISKPEAGAFHAACEALALEPQEVAYVGDEPDIDASGAVAAGLTGIWLDRQGRGGRPDLVTITGLDQLPGLLAGQTRFGAPDTFG
>NC_021177.1|WP_003966003.1|6040676_6041393_-|IclR-family-transcriptional-regulator-NdgR
MDNSSGVGVLDKAALVLSALESGPATLAGLVAATGLARPTAHRLAVALEHHRMVARDMQGRFILGPRLSELAAAAGEDRLLATAGPVLTHLRDITGESAQLYRRQGDMRICVAAAERLSGLRDTVPVGSTLTMKAGSSAQILMAWEEPERLHRGLQGARFTATALSGVRRRGWAQSIGEREPGVASVSAPVRGPSNRVVAAVSVSGPIERLTRHPGRMHAQAVIDSAARLSEALRRTG
>NC_021177.1|WP_015611643.1|6041566_6042994_+|3-isopropylmalate-dehydratase-large-subunit
MGRTLAEKVWDDHVVRRAEGEPDLLFIDLHLLHEVTSPQAFDGLRQAGRPVRRLDLTIATEDHNTPTLDIDKPIADPVSRAQLETLRKNCADFGVRLHPLGDVEQGVVHVVGPQLGLTQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVDGELPEDVTAKDLILAIITRIGTGGGQGYILEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAPDETTFAYLEGRDRAPRGEEWDAAVAYWKTLRSDDDAVFDAEVVIDATELAPFVTWGTNPGQGAPLSAHVPDPASYEDASERNAAEKALEYMGLTAGQPLREINVDTVFVGSCTNGRIEDLRNAAAILDGRKVANGVRMLVVPGSVRVALQAVSEGLDKVFTEAGAEWRHAGCSMCLGMNPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLSDTRTPAGVR

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Crispr_ID: NC_021177_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_21

6065875-6065977

Orphan

Consensus_repeat	Method
CGCGCAGGCCGGTGCTCACGGCAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_21

>merge|NC_021177|21|6065875-6065977|CRISPRCasFinder
CGCGCAGGCCGGTGCTCACGGCAGCACGGAATCCGCGCCCGGCGCGCAGCCCGCGCCTGCTGCACAGCCCGCGCCCGGCGCGCAGGCCGGTGCTCACGCCAGC

>NC_021177|21|19|6065875-6065977|CRISPRCasFinder
CGCGCAGGCCGGTGCTCACGGCAGC	ACGGAATCCGCGCCCGGCGCGCAGCCCGCGCCTGCTGCACAGCCCGCGCCCGG
CGCGCAGGCCGGTGCTCACGCCAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015611662.1\|6060246_6061107_+\|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	unknown	unknown	gnl\|CDD\|234899
NC_021177.1\|WP_015611672.1\|6072004_6072652_-\|bifunctional-DNA-primase/polymerase	unknown	unknown	gnl\|CDD\|214927
NC_021177.1\|WP_015611670.1\|6069536_6070517_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NC_021177.1\|WP_003965965.1\|6076314_6076653_+\|P-II-family-nitrogen-regulator	unknown	unknown	gnl\|CDD\|223424
NC_021177.1\|WP_015611676.1\|6079278_6080832_+\|signal-recognition-particle-protein	unknown	unknown	gnl\|CDD\|236780
NC_021177.1\|WP_015611677.1\|6080908_6081766_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|176222
NC_021177.1\|WP_015611667.1\|6063413_6063626_+\|hypothetical-protein	unknown	unknown	unknown
NC_021177.1\|WP_015611661.1\|6059312_6060137_+\|ribonuclease-III	unknown	unknown	gnl\|CDD\|234633
NC_021177.1\|WP_015611660.1\|6058502_6059117_+\|DUF177-domain-containing-protein	unknown	unknown	gnl\|CDD\|376863
NC_021177.1\|WP_015611659.1\|6057108_6058251_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349951
NC_021177.1\|WP_015611675.1\|6076684_6079147_+\|[protein-PII]-uridylyltransferase	unknown	unknown	gnl\|CDD\|235123
NC_021177.1\|WP_031124468.1\|6073092_6074568_+\|negative-regulator-NsdA	unknown	unknown	unknown
NC_021177.1\|WP_015611664.1\|6061551_6062523_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|349398
NC_021177.1\|WP_015611658.1\|6056499_6057009_+\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234674
NC_021177.1\|WP_015611671.1\|6070697_6071909_+\|signal-recognition-particle-docking-protein-FtsY	unknown	unknown	gnl\|CDD\|236686
NC_021177.1\|WP_078618764.1\|6062692_6062974_+\|acylphosphatase	unknown	unknown	gnl\|CDD\|237712
NC_021177.1\|WP_043973502.1\|6074971_6076318_+\|ammonium-transporter	unknown	unknown	gnl\|CDD\|223083
NC_021177.1\|WP_015611663.1\|6061079_6061466_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NC_021177.1\|WP_015611669.1\|6068088_6069507_+\|sugar-porter-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340917
NC_021177.1\|WP_003965982.1\|6059119_6059293_+\|50S-ribosomal-protein-L32	unknown	unknown	gnl\|CDD\|237038

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015611662.1\|6060246_6061107_+\|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase	gnl\|CDD\|234899	PRK01103, PRK01103, bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase.	9.37134e-147
NC_021177.1\|WP_015611672.1\|6072004_6072652_-\|bifunctional-DNA-primase/polymerase	gnl\|CDD\|214927	smart00943, Prim-Pol, Bifunctional DNA primase/polymerase, N-terminal. Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities.	1.34725e-16
NC_021177.1\|WP_015611670.1\|6069536_6070517_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	4.465e-32
NC_021177.1\|WP_003965965.1\|6076314_6076653_+\|P-II-family-nitrogen-regulator	gnl\|CDD\|223424	COG0347, GlnK, Nitrogen regulatory protein PII [Amino acid transport and metabolism].	4.44912e-51
NC_021177.1\|WP_015611676.1\|6079278_6080832_+\|signal-recognition-particle-protein	gnl\|CDD\|236780	PRK10867, PRK10867, signal recognition particle protein; Provisional.	0
NC_021177.1\|WP_015611677.1\|6080908_6081766_-\|SAM-dependent-methyltransferase	gnl\|CDD\|176222	cd08261, Zn_ADH7, Alcohol dehydrogenases of the MDR family. This group contains members identified as related to zinc-dependent alcohol dehydrogenase and other members of the MDR family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group includes various activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.08294e-07
NC_021177.1\|WP_015611661.1\|6059312_6060137_+\|ribonuclease-III	gnl\|CDD\|234633	PRK00102, rnc, ribonuclease III; Reviewed.	3.61229e-118
NC_021177.1\|WP_015611660.1\|6058502_6059117_+\|DUF177-domain-containing-protein	gnl\|CDD\|376863	pfam02620, DUF177, Uncharacterized ACR, COG1399. This family is nearly universally conserved in bacteria and plants except the Chlorophyceae algae. Thus far, mutantional analysis in bacteria have not established a function. In contrast, mutants have embryo lethal phenotypes in maize and Arabidopsis. In maize, the mutant embryos arrest at an early transition stage.It has been suggested that family members specifically affect 23S rRNA accumulation in plastids as well as bacteria.	2.03609e-28
NC_021177.1\|WP_015611659.1\|6057108_6058251_+\|hypothetical-protein	gnl\|CDD\|349951	cd06503, ATP-synt_Fo_b, F-type ATP synthase, membrane subunit b. Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.	2.86517e-06
NC_021177.1\|WP_015611675.1\|6076684_6079147_+\|[protein-PII]-uridylyltransferase	gnl\|CDD\|235123	PRK03381, PRK03381, PII uridylyl-transferase; Provisional.	0
NC_021177.1\|WP_015611664.1\|6061551_6062523_-\|hypothetical-protein	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	8.98549e-46
NC_021177.1\|WP_015611658.1\|6056499_6057009_+\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	2.44037e-99
NC_021177.1\|WP_015611671.1\|6070697_6071909_+\|signal-recognition-particle-docking-protein-FtsY	gnl\|CDD\|236686	PRK10416, PRK10416, signal recognition particle-docking protein FtsY; Provisional.	3.07132e-167
NC_021177.1\|WP_078618764.1\|6062692_6062974_+\|acylphosphatase	gnl\|CDD\|237712	PRK14422, PRK14422, acylphosphatase; Provisional.	3.77047e-50
NC_021177.1\|WP_043973502.1\|6074971_6076318_+\|ammonium-transporter	gnl\|CDD\|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	3.52203e-163
NC_021177.1\|WP_015611663.1\|6061079_6061466_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	2.5352e-32
NC_021177.1\|WP_015611669.1\|6068088_6069507_+\|sugar-porter-family-MFS-transporter	gnl\|CDD\|340917	cd17359, MFS_XylE_like, D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily. This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	9.94058e-150
NC_021177.1\|WP_003965982.1\|6059119_6059293_+\|50S-ribosomal-protein-L32	gnl\|CDD\|237038	PRK12286, rpmF, 50S ribosomal protein L32; Reviewed.	5.89913e-26

>NC_021177.1|WP_015611667.1|6063413_6063626_+|hypothetical-protein
MAKALLGYVGGSDPRLLAEMRRLQQRVQDLESELNRIQDENDALNAAAQHQDSLLDSIDIDVPQGEPALT
>NC_021177.1|WP_078618764.1|6062692_6062974_+|acylphosphatase
MNVDARLVVWVRGRVQQVGFRWFTRANALEIGGLVGFALNLDDGRVQVVAEGSRDNCHRLLDWLRSDDTPGRVDGVTEIWDTPRGGYEGFAIR
>NC_021177.1|WP_015611664.1|6061551_6062523_-|hypothetical-protein
MGRHRRSAAGPAAEEPAVGASSRHRGTRRKKKSAVPVRTGLLGASAAMAVGAVAVASGLLPGGDTYTSGGSSAADQVRTGGAPDLLTQQGGSSAPADRSSSPASRGSERPGAPSKTPSKSPSTTASKSPSGSASKTPSKSAAPSATPSKKPAATPSKESKAPPTTAPKKSTAPASRTPAPPKKSVAPPPTKKPAPSPSDTSARAEVLALVNQERSKVGCSPLTTSAPLTSLAQNFSEDMAARGFFDHTDPDGDTPWDRAAQAGVQGLAAENIARGQADAQAVMDGWMNSEGHRANILNCDYKTIGIGVHEGSGGPWWTQNFGF
>NC_021177.1|WP_015611663.1|6061079_6061466_-|helix-turn-helix-transcriptional-regulator
MASDTDVSAFDVFSRQCPSRSTLEHVTGRWGSLTLGALYEERLRFNELRRRVDGVSEKMLSQTLHALERDGLVLREAQPVNPPRVDYELTPFGREVAGQLLGLIHLVEGRMDDVIAARTRYDATRGGR
>NC_021177.1|WP_015611662.1|6060246_6061107_+|bifunctional-DNA-formamidopyrimidine-glycosylase/DNA-(apurinic-or-apyrimidinic-site)-lyase
MPELPEVEVVRRGLERWVSGRTVTEVEVLHPRAVRRHLAGGPDFAARLRGVRFGTAMRRGKYLWVPIDEAASSLLGHLGMSGQLLVQPTDAPDEKHLRIRMRFDDALGTELRFVDQRTFGGLSLHDTTPDGLPDTIAHIARDPLDPLFDDAAFHTALRLRRTTVKRALLDQSLISGVGNIYADEALWRAKLHYDRPTATLTRPKSAELLGHARDVMNAALAQGGTSFDSLYVNVNGESGYFDRSLDAYGREGEPCRRCGTPMRRRAWMNRSSYFCPRCQRPPRVAS
>NC_021177.1|WP_015611661.1|6059312_6060137_+|ribonuclease-III
MSELSSAKKQADNINTASSHTLLEGRLGYHLESALLVRALTHRSYAYENGGLPTNERLEFLGDSVLGLVVTDTLYRTHPDLPEGQLAKLRAAVVNSRALAEVGRGLELGSFIRLGRGEEGTGGRDKASILADTLEAVIGAVYLDQGLSAASELVHRLFDPLIDRSSNLGAGLDWKTSLQELTASESLGVPEYLVTETGPDHEKTFTAAARVGGVSYGTGTGRSKKEAEQQAAESAWREISAAAEARQAAEKSAADGGAADTPADPSPDTDAAPA
>NC_021177.1|WP_003965982.1|6059119_6059293_+|50S-ribosomal-protein-L32
MAVPKRKMSRSNTRHRRSQWKAAVPTLVSCERCQEPKLQHIACPSCGTYNKRQVLEV
>NC_021177.1|WP_015611660.1|6058502_6059117_+|DUF177-domain-containing-protein
MFDTRELGRRPGALKRLSRSVDAPGSPVLGIDGVIGVPEGAPLELDLRLESVMEGVLVTGTARASAEGECVRCLEPLTIEVDADFQEMFSYPDADDRGRSSAADPADDAEDDEDRFFLEDGLFDLESVLRDAVVLALPMQPVCKETCAGLCSECGIRLDENPGHHHDAVDIRWAALQGLADTVQDGEKDNMGGAEPGVDEKQEK
>NC_021177.1|WP_015611659.1|6057108_6058251_+|hypothetical-protein
MDVQKKLDEIVEAVGNARAMPMSASCVVNRAELLAMLEEVREALPGSLAHAQQLIGGQEQFAEQARQEAERIIQSAHAQRSSLIAETEIARQSQSEADRILSEARREAEEVRAEADDYVDSKLANFEVVLTKTIGSVDRGREKLLGRSQGLDEQGYQDPDFAEAPERSADPETLRQRADAYVDAKFGAFEAVLAKTLEAVGRGRQKLLGRVASDDLGAHMAAQDAAGAQGHTSDADYLAGLAELATPEPRQAPQQPLYQEPQQPQAEPGYAPTEYGQSEYGQPEYAQAAYGYQEQPHQQGAQGVQDPYGYQQVPDPYAAYQQPAYDPNQYPPQPQGRPDYGWQQQPQVPAQQNQGALDETSLFDTSMIDLEQLRRYEEGR
>NC_021177.1|WP_015611658.1|6056499_6057009_+|pantetheine-phosphate-adenylyltransferase
MTGPESEGITVRRAVCPGSFDPITNGHLDIIGRASKLYDVVHVAVMINQSKQGLFTVDERIELIREVTAGFGNVEVESFHGLLVDFCKQREIPAIVKGLRAVSDFDYELQMAQMNNGLSGVETLFVPTNPTYSFLSSSLVKEVATWGGDVSHLLPPAVHEALIGRLGKR
>NC_021177.1|WP_015611669.1|6068088_6069507_+|sugar-porter-family-MFS-transporter
MTSAANGPESGARAAHPDHLGHVIFITAAAAMGGFLFGYDSSVINGAVEAIRDRYDIGSGTLAQVIAIALIGCAIGAATAGRIADRIGRIRCMQIASVLFTASAIGSALPFALWDLAIWRVIGGFAIGMASVIGPAYIAEVSPPAYRGRLGSFQQAAIVIGIAISQLVNYTLLQIADGDQRGKILGLEAWQWMLGVMVVPAILYGLLSFAIPESPRFLISVGKKAQARKILEEVEGDKIDLDARVTEIETAMHREHKSSFKDLLGNRFFFLPIVWVGIGLSMFQQLVGINVAFYYSATLWQSVGIDPTDSFFYSFTTSIINIIGTVIAMVLVDRVGRRPLALVGSVGMAIALAFEAWAFSADLIDGKLPTTQGVVALVAAHVFVLFFALSWGVVVWVFLGEMFPNRLRAAALGVAVFAQWMANWAITASFPSLADWNLSGTYIIYACFAVLSIPFVLKFVKETKGKTLEEMG
>NC_021177.1|WP_015611670.1|6069536_6070517_-|LLM-class-flavin-dependent-oxidoreductase
MAFTVVRFNLVDPEATPVTLSARYRAALEMAAYADEHSVDTVQTEEHHGVANSWLPSPFTFAGAVFGATRRIAVTVSAIIGPLHDPLRLAEDIAVLDLLSAGRLVTVAGIGYRPEEYERAGVEWGRRGRLQDELLETLLTAWSGEPFPYRGRTVRVTPRPYTRPHPMLLVGGSSRAAARRAARLGLPLFPSAHLPELEAYYHQQRAVHGTEGFCMMPAARTPLLHVSEDPERTWALYGEHLLHEARTYAPWQSKDIRSAVRSAATTVAELREEGVYRIVTPEELAGLDAESLVLHPLCGGMPVEEGWRSLRLFCAALETPAAPVQQ
>NC_021177.1|WP_015611671.1|6070697_6071909_+|signal-recognition-particle-docking-protein-FtsY
MELVEIVILAVVIALAAVGLVGGLVVGSRKKRKLPPPPSSTPTITPPAEPQVGEEAETPRDEARRTIDEVGLPDATAPAEEAPAVEVPAPPALEVPEPTEGRLVRLRARLARSQNSLGKGLLTLLSRDNLDEDTWEEIEDTLLTADVGVAPTQELVERLRERVRVLGTRTPEDLRALLREELITLLGPELDREVRTEGGAETPGVVMVVGVNGTGKTTTTGKLARVLVADGRSVVLGAADTFRAAAADQLQTWGERVGARTVRGPEGGDPASIAYDAVKEGIAEGADVVLIDTAGRLHTKTGLMDELGKVKRVVEKHGPLDEILLVLDATTGQNGLVQARVFAEVVDITGIVLTKLDGTAKGGIVIAVQRELGVPVKLIGLGEGADDLAPFEPGAFVDALIGD
>NC_021177.1|WP_015611672.1|6072004_6072652_-|bifunctional-DNA-primase/polymerase
MGFTIGGIREKRSGARRRGRSAESTAVAEYTGLWGWAVVPGTRARAGACSCGQRACPSPGAHPLGFAREVPAGTGLDRAADAWAETPGASMLLPVGRAFDVLDVAEQAGRRALVRLERMGLPLGPVTVTPTGRAQFFVAPGAAAELPGLLYRMGWDDADLDLRALGPGTHITAPPSDLGGLGPVRWLRPPVLDTAAAPPQARLLLGTLAYVCHRS
>NC_021177.1|WP_031124468.1|6073092_6074568_+|negative-regulator-NsdA
MSGSGAGDTDAGKRPNGQLGSWFVRSGWSKGELARQVNRRARQMGAHHISTDTSRVRRWLDGEQPREPIPRILSELFSERFGAVVAVEDLGLRTAHQSPSVAGVDLPWAGPQTVALLSEFSRSDLMLARRGFLGSSLALAAGPALIEPMQRWLVPAPARGPGEPESEAAARRPSRLSGPELDLLESTTAMFRQWDAQCGGGLRRKAVVGQLHEVTDLLQEPQPGPTAKRLFRCAAELAELAGWMSYDVGLQPTAQKYFVLALHAAKEAGDKPLGSYVLSSMSRQMIHLGRPDDALELIHLAQYGSRDCATPRTQAMLYAMEARAYANMGQPSKCKRAVRMAEDTFLDAGLDGEPEPDWIRFFSEAELNGENAHSYRDLAYVAGRSPTYASLAEPVMEKAVELFGEDDEHQRSYALNLIGMATVHLLQREPEQSTVLAGQALKIARKVRSERVNTRLRKTVDTAARDFGDVADVARLTDLLSEQLPETAETV
>NC_021177.1|WP_043973502.1|6074971_6076318_+|ammonium-transporter
MPPGITTLAADAPELSAANTGFMLICSALVMLMTPGLAFFYGGMVRVKSTLNMLMMSFISLGIVTILWVLYGFSLAFGSDVGSVIGWSSDYVGFSNIGVTELWDGYTIPVYVFAAFQLMFAILTPALISGALADRVKFSAWALFIVLWVTIVYFPVAHWVWGAGGWLFELGVIDFAGGTAVHINAGAAALGVIFVIGKRIGFKKDPMRPHSLPLVMLGAALLWFGWFGFNAGSWLGNDDGVGAVMFLNTQVATAAAVLGWLAYEKLRHGSFTTLGAASGAVSGLVAITPAGGSVSPLGAIAVGAIAGVLCAMAVGLKYKFGYDDSLDVVGVHLVGGVIGSILVGFFATGGVQSDAKGLFYGGGVDQLGKQVVGVVAVLAYSLVVSGLIALVLHKTIGMRVSEDEEISGIDQIEHAETAYDFSGAGGGTVSRTPAQDTTAAPKAKKVDA
>NC_021177.1|WP_003965965.1|6076314_6076653_+|P-II-family-nitrogen-regulator
MKLITAVVKPHRLDEIKEALQAFGVQGLTVTEASGYGRQRGHTEVYRGAEYTVDLVPKIRIEVLVEDEDAEQLIEVVVKAARTGKIGDGKVWSVPVETAVRVRTGERGPDAL
>NC_021177.1|WP_015611675.1|6076684_6079147_+|[protein-PII]-uridylyltransferase
MTSTEAITDSEDSGPSGYAAARLRLLQQEARSGPPRRAALAGLTDDWLTGLFTSAAARAGVRGAALVAVGGYGRGELSPRSDLDLLLLHDGSADAAAVAALADGIWYPVWDLGLALDHSVRTPGEARKTAGEDLKVQLGLLDARPVAGDLGLVASLRTAILADWRNQAPKRLPALHELCQERAERMGELQFLLEPDLKEARGGLRDATALRAVAASWVADAPREGLDQARRILLDARDALHLTTGRATDRLALQEQDQVAEALGLMDADALLRQVYEAARTVSYATDVTWREVNRVLRARSVRPRLRAMLSGGRVSAKPAPERAPLADGVVEADGEVVLARAARPDRDPVLTLRAAAAAAEAGLPLSRHLVRHLATTVRPLPVPWPPEAREELVTLLGAGESAIGVWEALEAEGIITRLLPDWERVHCRPQRNPVHTWTVDRHLVETAVRAASLTRRVHRPDLLLVAALLHDIGKGWPGDHSVAGEVIARDMATRIGFDKHDVGVIATLVRHHLLLVETATRRDLDDPATVRSVAEAVSTASTLELLHALTEADALATGPAAWSTWRASLVTDLVKRVAAVLAGEAPEEPEEAAPSAEHERLAIEALRTGEPALTLHTHPEEPAGEGEVEPVGVELLIALPDRPGVLPAAAGVLALHRLTVRAADLRAVELPNELGERADLLLLSWRVAAEYGSLPQATRLRADLVRALDGSLDIRARLAEREAAYPRRRGVKAPPPRVAVAAAGSRRATVIEVRAQDAPGLLHRIGNALEGCAVRVRSAHVSTLGANAVDAFYVTGTDGEPLPEVRAAEVAREVEKALG
>NC_021177.1|WP_015611676.1|6079278_6080832_+|signal-recognition-particle-protein
MFDTLSDRLSATFKNLRGKGRLSEADIDATAREIRIALLEADVALPVVRAFIANVKERARGVEVSQALNPAQQVVKIVNEELVSILGGETRRLRFAKNPPTVIMLAGLQGAGKTTLAGKLGLWLKSQGHSPLLVACDLQRPNAVNQLSVVAERAGVAVYAPEPGNGVGDPVQVAKDSIEFAKTKVHDIVIVDTAGRLGIDQELMSQAADIRDAVSPDEILFVVDAMIGQDAVNTAEAFRDGVGFDGVVLSKLDGDARGGAALSIAHVTGKQVMFASNGEKLEDFDAFHPDRMASRILDMGDLLTLIEQAEKTFSQEEAAKMASKLSSSKGGKDFTLDDFLAQMEQVRKMGSISKLLGMLPGMGQIKDQINNIDERDIDRTAAIIKSMTPKERAEPTIINGSRRARIAKGSGVEVSAVKSLVERFFEARKMMSKMAQGGGMPGMPGMPGMGGGPGRQKKQIKQAKGKRKSGNPMKRKAEEAAAAERREQAAAQGGAFGLPAQEDKNFELPDEFKKFMG
>NC_021177.1|WP_015611677.1|6080908_6081766_-|SAM-dependent-methyltransferase
MTPTLVRNHRDADLSAPADAGTRARDWAEIQERMLAPLYEAVYDRLEVGPATRMLSLGCGSGLAMLVAAARGAHVTGVDSDRERLALARARLLPDEGAEGAPAHRARLHDDGLPAGAGADGAPYDLITVFEPIGCAAGDSEGLVPALESALPLAARGATVVLTGWGPPERCATAPVLRVAARLAESTRPPRPGGWRPTLRDDLEDVAARAGLKPDGSGRVSCPFGYADPDSAVRGLLSTGLFDAAVRATDRSQVEKEVAEALHPYRRADGTVWMPNVFRYLVCTT

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Crispr_ID: NC_021177_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021177_22

7166923-7167027

Orphan

Consensus_repeat	Method
CACCCGCCATGCCCGACCTCGGTGCGCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021177_22

>merge|NC_021177|22|7166923-7167027|CRISPRCasFinder
CACCCGCCATGCCCGACCTCGGTGCGCCCCCGCCGGGCACGTACCGACCGCATCACCACCCCCACCACCCCGCAGCACCCGCCATGCCCGACCTCGGTCCGCCCC

>NC_021177|22|20|7166923-7167027|CRISPRCasFinder
CACCCGCCATGCCCGACCTCGGTGCGCCCC	CGCCGGGCACGTACCGACCGCATCACCACCCCCACCACCCCGCAG
CACCCGCCATGCCCGACCTCGGTCCGCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021177.1\|WP_015612551.1\|7150974_7151817_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl\|CDD\|234823
NC_021177.1\|WP_015612565.1\|7169733_7170909_+\|metabolite-traffic-protein-EboE	unknown	unknown	gnl\|CDD\|366542
NC_021177.1\|WP_015612566.1\|7170905_7172327_+\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366747
NC_021177.1\|WP_015612557.1\|7158395_7159640_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_021177.1\|WP_015612571.1\|7177868_7179824_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380546
NC_021177.1\|WP_015612567.1\|7172382_7173459_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_021177.1\|WP_015612554.1\|7154610_7156134_+\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NC_021177.1\|WP_015612553.1\|7153134_7154316_+\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NC_021177.1\|WP_015612555.1\|7156130_7157183_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224093
NC_021177.1\|WP_015612563.1\|7168206_7168881_+\|EboA-domain-containing-protein	unknown	unknown	unknown
NC_021177.1\|WP_043975045.1\|7160942_7164662_+\|DUF1080-domain-containing-protein	unknown	unknown	gnl\|CDD\|377643
NC_021177.1\|WP_015612558.1\|7159653_7160658_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_021177.1\|WP_015612552.1\|7152026_7152986_+\|ketoacyl-ACP-synthase-III	unknown	unknown	gnl\|CDD\|236475
NC_021177.1\|WP_164711341.1\|7176316_7177879_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224053
NC_021177.1\|WP_015612562.1\|7167322_7168213_+\|TIM-barrel-protein	unknown	unknown	gnl\|CDD\|366542
NC_021177.1\|WP_015612564.1\|7168880_7169729_+\|TatD-related-deoxyribonuclease	unknown	unknown	gnl\|CDD\|224024
NC_021177.1\|WP_015612569.1\|7175279_7176296_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_021177.1\|WP_015612560.1\|7164756_7165923_+\|Myo-inositol-1-phosphate-synthase-Precursor	unknown	unknown	gnl\|CDD\|369641
NC_021177.1\|WP_015612568.1\|7173486_7174791_-\|DUF2254-domain-containing-protein	unknown	unknown	gnl\|CDD\|378351
NC_021177.1\|WP_031123412.1\|7157286_7158324_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380534

Protein	Function_ID	Function_description	E-value
NC_021177.1\|WP_015612551.1\|7150974_7151817_-\|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl\|CDD\|234823	PRK00724, PRK00724, formate dehydrogenase accessory sulfurtransferase FdhD.	9.46906e-124
NC_021177.1\|WP_015612565.1\|7169733_7170909_+\|metabolite-traffic-protein-EboE	gnl\|CDD\|366542	pfam01261, AP_endonuc_2, Xylose isomerase-like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.	1.11073e-09
NC_021177.1\|WP_015612566.1\|7170905_7172327_+\|alkaline-phosphatase-family-protein	gnl\|CDD\|366747	pfam01663, Phosphodiest, Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.	1.66527e-68
NC_021177.1\|WP_015612557.1\|7158395_7159640_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	2.62919e-65
NC_021177.1\|WP_015612571.1\|7177868_7179824_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|380546	cd06323, PBP1_ribose_binding, periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs. Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis D-ribose binding protein (ttRBP) and its mesophilic homologs. Members of this group belong to the type 1 periplasmic binding protein superfamily, whose members are involved in chemotaxis, ATP-binding cassette transport, and intercellular communication in central nervous system. The thermophilic and mesophilic ribose-binding proteins are structurally very similar, but differ substantially in thermal stability.	6.4592e-122
NC_021177.1\|WP_015612567.1\|7172382_7173459_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	1.68658e-26
NC_021177.1\|WP_015612554.1\|7154610_7156134_+\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NC_021177.1\|WP_015612553.1\|7153134_7154316_+\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.49631e-70
NC_021177.1\|WP_015612555.1\|7156130_7157183_+\|ABC-transporter-permease	gnl\|CDD\|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	2.87728e-83
NC_021177.1\|WP_043975045.1\|7160942_7164662_+\|DUF1080-domain-containing-protein	gnl\|CDD\|377643	pfam06283, ThuA, Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.	9.10834e-108
NC_021177.1\|WP_015612558.1\|7159653_7160658_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	2.85586e-28
NC_021177.1\|WP_015612552.1\|7152026_7152986_+\|ketoacyl-ACP-synthase-III	gnl\|CDD\|236475	PRK09352, PRK09352, beta-ketoacyl-ACP synthase 3.	1.48571e-151
NC_021177.1\|WP_164711341.1\|7176316_7177879_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NC_021177.1\|WP_015612562.1\|7167322_7168213_+\|TIM-barrel-protein	gnl\|CDD\|366542	pfam01261, AP_endonuc_2, Xylose isomerase-like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.	5.68887e-32
NC_021177.1\|WP_015612564.1\|7168880_7169729_+\|TatD-related-deoxyribonuclease	gnl\|CDD\|224024	COG1099, COG1099, Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only].	5.65532e-90
NC_021177.1\|WP_015612569.1\|7175279_7176296_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	9.35921e-118
NC_021177.1\|WP_015612560.1\|7164756_7165923_+\|Myo-inositol-1-phosphate-synthase-Precursor	gnl\|CDD\|369641	pfam07994, NAD_binding_5, Myo-inositol-1-phosphate synthase. This is a family of myo-inositol-1-phosphate synthases. Inositol-1-phosphate catalyzes the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. Inositol phosphates play an important role in signal transduction.	1.358e-88
NC_021177.1\|WP_015612568.1\|7173486_7174791_-\|DUF2254-domain-containing-protein	gnl\|CDD\|378351	pfam10011, DUF2254, Predicted membrane protein (DUF2254). Members of this family of bacterial proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.	5.10718e-107
NC_021177.1\|WP_031123412.1\|7157286_7158324_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|380534	cd06311, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of uncharacterized ABC-type transport systems. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	3.61409e-80

>NC_021177.1|WP_015612560.1|7164756_7165923_+|Myo-inositol-1-phosphate-synthase-Precursor
MTAHADREGRTDAPGRADNSGRTGVWFIGARGSVATTATAGCAAIAAGLHPPTGMVTETPPFADSGLPPLTSLVFGGHDTLDCPLAKRAEALAEGGVLPHRLPSAVRAELDAADAEIRPGGPLPGDTRTDEELIAAFAADLTDFAHRHELARTVVINVSSTEPAPGPDDPRLPASSLYAAAALRAGCSYANFTPSTGLRAAALTDTVADCGLPHAGRDGKTGQTLLRSVLAPMFLQRALPVRAWSGSNLLGGGDGAALADPAAAAAKNAGKERVLTDTFGTAPEGEVHIDDVPAMGDWKTAWDHIAFDGFLGSRMVLQTIWQGCDSALAAPLVLDLARLLARSHEAGLSGPRPELGFYFKDPDGGTSAALAEQYATLLAFAERLRGQA
>NC_021177.1|WP_043975045.1|7160942_7164662_+|DUF1080-domain-containing-protein
MHRTRKRLLARTRVRKSLALFTGALLAAATLTLGSAPGATAHPGHPGHEEPVAEDFQQVTLAKGAEETGEPMSLAVLPDRSVLHTSRNGELRITDSAGNTKVSGTLPVYTHDEEGLQGVGVDPDFAENRAIYLFYAPPLDTPAGDAPETGTAADFAKFDGVNRLSRFVLNEDGTLDTASEKKVLDVPTSRGICCHVGGDIDFDKDGNLYLSTGDDTNPFASDGFTPIDERPDRNPAFDARRTSGSTNDLRGKILRIKVAEDGSYTVPEGNLFEPGTDKTRPEIYAMGFRNPFRFSVDQATGIVYVGDYGPDAGSADPKRGPSGKVEFARVTKAGNFGWPYCVGENEPYIDYDFATKTSGAAFDCANLKNESPHNTGLVDLPPAEAAWIPYDGGSLPEFGTGSESPMGGPVYRYDADLDSPVKFPEAYDGDFFAGEFGRKWIKRIEQDADGAVQSINDVPWSGTQIMDMAFGPDGALYVLDYGLAWFGGDENSALYRIENATGGRSPIAEASANKTSGTAPLKVKFSSAGTADGDDDPLTYAWDFGDGGTSTAANPTYTYKKNGTYTATVTAEDPTGRTGSASVHVTVGNTAPTVELVLPEDGQLFAFGDSVPFKVNVSDPEDGTIDCTKVEVKFTLGHDSHGHDITTEHGCEGTIKTAMEGGHDPNANIYGGISASYTDNGGGGQAKLTGKDTSRLQPRHRQAEHYDNSSGVTTPSKAGAHGGKTVGDIHNDDWISFNTYVLGGTTKLTARISSAGSGGFLEVRTGSPTGKILGSGPVPVTGSWDTFQDIDIPLRGAPKKQTELFLVFKGGDGALYDIDDFELSNSPVDKTAKRVLVFSKTAGFRHDSIPAGIAALKEIGKDTNITVDSTESAAQFTTSNLARYDAVAFLSTTGDVLNAEQQKAFENYVATGGGYVGIHAAADTEYEWEFYGGLVGAYFDSHPQIQPATVRVEDHDHPATAHLDEEWERTDEWYNYRTNPRDKAKVLATLDETTYTGGNMKGDHPISWCQTYQGGRSFYTGLGHTKESYAEAAFRQHVSGGLRYATGQVKADCKPDKDYRPIFNGKTLEGWKQAGPGKFSVSDGALHSEGGMGLLTYQAKELKAYSLKLDWKMAGDDNSGIFVGFPESDDPWSAVNNGYEIQIDATDAADRTTGAVYTFKSANIKARDRVLRPPGQWNSYEIKVQGERLQVFLNGAKINDFTNTDPARSLKDGYIGLQNHGADDQVSFRNIQLKELPST
>NC_021177.1|WP_015612558.1|7159653_7160658_+|sugar-phosphate-isomerase/epimerase
MPRPFTLFTGQWADLPLEEVCRHARDFGYDGLELACWGDHFEVDKALADPGYLDSRHQLLDKYGLKCFAISNHLVGQAVCDNPIDERHQGILPARIWGDGEAEGVRQRAAAEIADTARAAAAFGVDTVIGFTGSSIWHLVAMFPPVPPHMIERGYEDFAERWNPILDVFDAEGVRFAHEVHPSEIAYDYWTTKRALEAVDHRPAFGLNFDPSHFVWQDLDPVGFLYDFRDRIYHVDCKEARKRLDGRNGRLGSHLPWGDPRRGWDFVSAGHGDVPWEDVFRMLRSIGYEGPVSVEWEDAGMDRLHGAPEALASLKRFDFDPPSASFDAAFGGGE
>NC_021177.1|WP_015612557.1|7158395_7159640_+|Gfo/Idh/MocA-family-oxidoreductase
MARSQETEAQTAAPPPQQARGTLGVGMVGYAFMGAAHSQGWRTAGHVFDLPVRPSLAAICGRDRAAVDAAAARHGWAAAETDWRALIARDDVQLIDICTPGDSHAEIAIAALEAGKHVLCEKPLANTVAEAEAMVRAAEAAEARGQVAMVGFNYRKVPAITYARQLIADGRLGTLRHVRASYLQDWLVDPASPLTWRLKREHAGSGALGDLGAHIVDLAQYLAGELLTGVSAVSETFVRERPLLSRTPAGTSAALSGAADAVERGEVTVDDAAIFTGRLASGALASFEATRMAAGRKNALRLEINGELGSLAFDLERLNELSFHDHTEPAATAGFRRILVTEPEHPYLEAWWPPGHALGYEHTFVHQARDVVRTITEGTPARPSFADGLQVQRVLAAVEESAAKNSVHTPVPSS
>NC_021177.1|WP_031123412.1|7157286_7158324_+|substrate-binding-domain-containing-protein
MPETSRRGLLFGASAISAGALLTACTSNEPKNAQPASNSQPAADDKPGKPVTIGFAGPQADHGWLNAINVNAKSRAEKYSEVTLEITEGSNDTAAQIGQVKTLINKKVDVLVILPADGKALTQVGLEAMRAGIPVVNLDRIFASPQAYRCWVGGDNYGMGLNAGHYIGEQLKGKANAKVVELAGIDNLELTKQRSQGFADALKNYPNIKLVARQAAEFTVESGQAKMAQLLQAQKQIDALWNHDDDQGVGALRAIQQAGRDEFIMVGGAGAKSAMDAIKADNSVIKATVLYPPTMAASAIDLARALGQSKGVSGLSEMEIPTSLTLYSAVVTKDNIDQYLPTGFN
>NC_021177.1|WP_015612555.1|7156130_7157183_+|ABC-transporter-permease
MTQPAPSAQHNGPDKGALAGPSDAPPSKTGGGRPALGLRLDVRILSLLGVLAALILVGGITEPDSFLDTGNLQLILTQASVIGVVTVGMTFVIISGGIDLSVGAMVALASVWATTLATQEYGFAGIAFTAVVVGLAAGLVNGVLIAYGGMVPFIATLAMLASARGLALQITDGKTQIVTVDSVLNLGLPDSYILGIPPLVIMFAAVTVIGWLVLNRTTFGRRTVAVGGNAEAARLAGIDVRRQRLYLYLLSGLCCGIAAFMLIVLAGSGQNTNGNLYELDAIAAAIIGGTLLSGGRGTIVGSVLGVLIFTTITNIFALNNLQSDVQQIAKGAIIVAAVLVQRRTLRGGET
>NC_021177.1|WP_015612554.1|7154610_7156134_+|sugar-ABC-transporter-ATP-binding-protein
MAPEPPLLTMSGITKSFPGVRALDGVDLEVQAGEVHCLLGQNGAGKSTLIKVLAGAHQPDDGEITWRGEAVRLKSPIAAMRLGIATIYQELDLVEGLSVAENVFLGHEPTSAGFIVRTGEGRLAAKALLARLGHPEIDPARAVGDLSAAQQQIVSMARALSHDVRLIVMDEPSAALDPDEVDNLFRIVDSLTADGVAVVYISHRLEEIRRIGDRVTVLKDGRAVAVGLPAADTPTRDIVAMMTGRDVEYVFPPRPDEASENITEPVLRVRGLSRKGEFAPVDLELRPGEIVGLAGLVGSGRSEILETIYGARKASTGTVTVAGKQLRPGSVRAAVAAGIGLAPEERKAQALLMTESVTRNVSVSSLSRFARVGWIDRGGERRAAQQATRELSLRPDNPDTPVRTLSGGNQQKAVLARWLLRGCRVLLLDEPTRGVDVGARAELYAVIRRLADEGLAVLLVSSEVPEVLGLADRVLVLREGHVVHAAPAQELDEHRVLDLVMEGSPTP
>NC_021177.1|WP_015612553.1|7153134_7154316_+|ROK-family-transcriptional-regulator
MTARPANAHQARLLRLLRDGGPNSRAQLGDQVDLSRSKLAVEVDRLLETGLVVADGLAASRGGRRSHNIRLAPELRFLGVDIGATSIDVAVTNAELEVLGHLNQPMDVREGPVAVFEQVLAMAAKLRASGLAEGFDGAGIGVPGPVRFPEGVPVAPPIMPGWDGFPVREALSQDLGCPVMVDNDVNLMAMGEQHAGVARSVGDFLCVKIGTGIGCGIVVGGEVYRGTTGSAGDIGHIQVEPDGRACACGNKGCLEAHFSGAALARDAEDAAREGRSPELAARLEAAGRLTAADVAAAAAAGDAAALDLIREGGNRVGQVIAGLVSFFNPGLVVIGGGVTGLGHNLLASVRTQVYRQSLPLATGNLPIVLGELGPTAGVIGAARLISDHLFSPA
>NC_021177.1|WP_015612552.1|7152026_7152986_+|ketoacyl-ACP-synthase-III
MTGSRVVALGHYQPAKVLTNDDLAAMVDTSDEWITSRVGIKTRHVGGPDEPVDELAAHAGAKALAAAGLQPSDIDLVLVATSTAIDRSPSMSARVAARLSMGSPAVMDINVVCSGFTHALAVADHTIRAGAATRALVIGADKMGDIADWTDRTTCVLLGDGAGAAVVTADPSAPDTPGGPGIGPVLWGSVPEMGNAVRIEGTPPRFAQEGQSVYRWATTQLPPIARKVCEKAGVAPEDLAAVVLHQANLRIIEPVARKIGAVNAIIARDVVDSGNTSAASIPMALSKLVERGEVASGAPVLLFGFGGNLSYAGQVIRCP
>NC_021177.1|WP_015612551.1|7150974_7151817_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MRRVTERRRTLRIRDGAVSSRADTLVAEEPLEIRLNGKPLAITMRTPGDDFALAAGFLVSEGVIAEGDEVQSIVYCAGATADGVNTYNVVDVKLAPGVVVPDITLERNVYTTSSCGLCGKASLDAVRTTTRHPVGDTPPVRVTPELLSALPDRLREAQKVFDRTGGLHAAALFSEEGELLDVREDVGRHNAVDKLVGRALTDGRLPLSRAVLLVSGRASFELAQKAVMAGIPVLAAVSAPSSLAVDLAAESGLTLVGFLRGPSMNVYAGEHRIALEAGVH
>NC_021177.1|WP_015612562.1|7167322_7168213_+|TIM-barrel-protein
MTLHLGYGTNGLTDLRLDDALGLLADLGYEGVGLTLDHMHLDPLAPDLAERTRQVRRRLTSLGLRVTVETGARYVLDPRRKHGPSLLDPDPDARAARTALLVRAVDVAAELGAHAVHCFSGITPPDTSAETAWKRLTEAITPVLEAADRSGIPLAIEPEPGHLLATLADFHHLRGLLGDPGPLGLTLDIGHCQCLEEMSPVSCVQDSAPWLRHVQIEDMRRGVHEHLPFGEGEIDFPPVLAALAACDYRGLTVVELPRHSHAGPELARTSIDFLRDAMTKGVAPTGAMTPRGGAPC
>NC_021177.1|WP_015612563.1|7168206_7168881_+|EboA-domain-containing-protein
MLKSRKELDAELDGAARAWLDGALAEAAHDATAREAARAQADVGAGTTPPGSPYASPPWELRYAAAGRHCGPAHADSVRSLLLIEASAPLPSVTRLYEQGTAAERRAVLLTLDRLGLGDRALPLVEDALRTNDTRLVAAAVGPYAAAHLDPHAWRHAVLKCLFTGVPVDAVARLGERARGDAELARMLRDFAAERTAAGRDVPADLRTALALALTTPAAPTEES
>NC_021177.1|WP_015612564.1|7168880_7169729_+|TatD-related-deoxyribonuclease
MRIFDPHIHMTSRTTDDYQAMYDAGVRALVEPSFWLGQPRTSPASFFDYFDALLGWEPFRASQYGIAHHCTLALNPKEANDPRCTPVLDALPRYLVKDSVVAVGEIGYDSMTPAEDHALAAQLQLAADHGLPALVHTPHRDKLAGLHRTIDVIRESHLSPEHVLLDHLNETTVKAATDSGCWAGFSIYPDTKMDEDRMVTILRNHGTEKILVNSAADWGKSDPLKTRKVADAMLKAGFTEDDVDKVLWRNPVAFYGQSGRLQLDTPAPDTLHEGNSILRGGE
>NC_021177.1|WP_015612565.1|7169733_7170909_+|metabolite-traffic-protein-EboE
MRFRHPDGSTVHLSYCTNVHPAETLDGVRAQLRDHCEPVRRRLGRDRLGIGLWLARDAARALINDPAELRALRAELDGRGLEVVTLNGFPYEGFGAAEVKYRVYRPDWTEPDRLAHTTDLARLLAALLPDDVTEGTISTLPLAWRTPYDTDPGAARTARTALTTLAQRLDALAELTGKSIRIGLEPEPGCTVETTADAIAPLTDVGHERIGICVDTCHLATSFEEPETALDALAAAGIPVVKSQLSAALHAEHPHLPEVRTALAAFAEPRFLHQTRTRTAAGLRGTDDLDEAVAGGALPDSTPWRAHFHVPLHAPPAPPLTSTLPVLRTTLARLVGGPVPLTRHLEVETYTWQALPAELRPRTRTQLADGIAAELTLARDLLVDLGLKELP
>NC_021177.1|WP_015612566.1|7170905_7172327_+|alkaline-phosphatase-family-protein
MSNDAPGTTTGTADRKGPTPLLVLDVVGLTPQLLSHMPNLTALGKQGARAPLSTVLPAVTCAAQSTFLTGTMPAEHGIVANGWYFRELGDVLLWRQHNGLVEGDKLWDAARRAHPGYTVANICWWYAMGADTDWTVTPRPVYYADGRKEPDCYTRPPALHDELTDKLGTFPLFHFWGPGADLVSSQWIIDATRHIIATRTPDLALCYLPHLDYDLQRYGPDDPRSHRAAADLDRAIAPLLADARAEGRTVVALSEYGITRVSHPVDINRALRRAGLLEVHTQDGMEYLDPMASRAFAVADHQLAHIYVRRPEDLEATRAALADLPGIDQLLDDEGKKAHHLDHPRSGELVAVAEKDAWFTYYYWLDDARAPDFAQLVEIHRKPGYDPVELFMDPEDPYVRLKAVSAVARKKLGMRYRMAVVPLDPSPIRGSHGRLPESDDEGPLILCSTPHAFTDRVRATEVKSLLLQLAGLH
>NC_021177.1|WP_015612567.1|7172382_7173459_+|sugar-phosphate-isomerase/epimerase
MSRTSKDTELARRLSRRNILGVAAGATAATIIGTATAQAAGRDHTQGPGKGHGHGHGHGKGKPVLPPGRLGIQLYSLRDKISTLGFAPVFAELEKYGYDEIELAGYTQGSAGPITLPQLKRLAKDHGLNPIGSHVGYYDDNNPGAYTFAQNLEKVLDDAQALGLKHIGTASGPFRYGSTVDGWKRAADDFNKYGAAARKRGMKFYQHNHAEEFSFATDKPKVRLYDVLLAETDPDLVYLELDIYWAYCAQFRFSKRVDGTKAPLDPLKYVLKHPNRYPLFHVKDGVRDDTTRDGYRMSDVGDGDIDYTTFLSKVTNRTHHGRTYHHWQAEHDNPVESLAFARKSSEHLHSLREGRCGD
>NC_021177.1|WP_015612568.1|7173486_7174791_-|DUF2254-domain-containing-protein
MSDRGYRRPRPLSPLREHLRDTFWFAPTMGFVCVFVLWLAASAVDEEIVAVLQREEAYDELGSLISFVQDAKTIVTTISSAMMTFIGVVFSISLVAVQMASGQLTPRVVRIFVRSRISKLTLTVFLATFLFSLLVLTSYESEADPRLVVSVPLLQSMLTLVLVGLSLLLFVVYVSATLRLMQVGPVVDRIARDSFRVLGRMPRGPGGPEGLGPETGRVVHEGRAGVLRDVNTARLVRAARRQDVVLRLIPRIGDFVVPGTPVLAVHGGAVPPRSRLRYSVSVGVERTLHQDLAFGLRQLSDIALRALSTSVNDPTTAVQCLDRSIQFLAAVVHLPLGTVHHRDRSGRVRLVQEGPGWESLVDLAFEEIRWCVAGSPQVSRRLLAGLDDLLLLAPEERKQPLVRHRALLVQAVERTVPVAADREFALLPDRQGIG
>NC_021177.1|WP_015612569.1|7175279_7176296_+|LacI-family-DNA-binding-transcriptional-regulator
MASIKDVAAQAGVSVATVSRVLNSHPSVSAEARTRVIAAVDALGYRPNAVARSLRTAQTRTLGLVISDVLNPYFTELARFVEEEARALGYSVIIGNADERPELQDHHIRTLIDRRIDGLLVSPADGGSPLMREVALSGTPMVFVDRWIPGIDVPVVRADGTGAVRDLVAHLHGLGHRRLAIIAGPAATTTGNERVEAFRDAMRELGLALPDAYIGQGDFQAASGRRATEGFLALDEPPEVVFAADNLMALGALDAIRARGLRVPGDIALAAFDDIPWFVHTDPPITAIAQPTADLARAAVRALADLIEGRTPQSVTLPARLVVRRSCGQDATDQRSDR
>NC_021177.1|WP_164711341.1|7176316_7177879_+|ATP-binding-cassette-domain-containing-protein
MATPDELLRIEGLRKTFPGVVALDNVDFDLRRGEVHVLLGENGAGKSTLIKMLSGAYRPDSGRILAEGREVRINNAQDAERLGIATIYQEFNLVPDLTVAENIFLGRQPRRFGLIDHRRMRVDAEKLLRRVGVDVRPDAKVRELGIARLQMVEIAKALSLDARVLIMDEPTAVLTSEEVDKLFAIVRQLRTDGVGIVFITHHLEEIAALGDRVTVLRDGRSIDQVPASTPEDGLVQLMVGRSIEQQYPRERPDTGEALLSVRGLTRDGVFHDISFDVHAGEVVGLAGLVGAGRTEVARAVFGADPYDAGTVDVRGERLARHDVPAAMGAGIGLVPEDRKGQGLVLDASVQENLGLVTLRSATRSGLVDLKGQRTAAARIAKQLGVRMSGLGQHVRTLSGGNQQKVVIGKWLLADTRVLILDEPTRGIDVGAKVEIYQLINELTASGHAVLMISSDLPEVLGMSDRVLVMAQGRIAGELPAGEATQDTVMALAVSTAATHEHPAPKNHPAPKNDEEGPRGH
>NC_021177.1|WP_015612571.1|7177868_7179824_+|substrate-binding-domain-containing-protein
MATETLKSDTGAGGTSVIRRVLLDNGALSALVVLVVAMSLLSGDFLTTQNLLNVGVQAAVTAILAFGVTFVIVSAGIDLSVGSVAALSATVLAWSATSAGVPVVLAVVLAIVTGIACGFVNGALISYGKLPPFIATLAMLSIARGLSLVISQGSPIAFPDSVSRLGDTLGGWLPVPVLVMIAMGLITALILGRTFIGRSMYAIGGNEEAARLSGLRVKRQKIVIYALSGLFAAVAGIVLASRLVSAQPQAAQGYELDAIAAVVIGGASLAGGVGKASGTLIGALILAVLRNGLNLLSVSAFWQQVVIGVVIALAVLLDTLRRKAGSGTAPSAGAAPGAPGSGRRGAFKFAGAALAVAVVVGGVSYFNSGSSGGTTKVGMSLSTLNNPFFVQMKDGAQAEAKKAGIDLTVTDAQNDASQQANQLQNFTSSGVSSIIVNPVDSDAVGPGVRSANKADIPVIAADRGVNKADTATLVASDNVAGGRLAADALADKLGGKGSIVILQGTAGTSASRERGAGFAEGLKAYPDIKVVAKQPADFDRTKGLDVMTNLVQSHPGITGVFAENDEMALGAVKALGSKAGTSVSVVGFDGTPDGLKAVGAGTLYASVAQQPSELGRIAVQNAVKAAKGDTVEKTVKVPVKVVTRENVADFS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021177_14	14.2\|4727118\|36\|NC_021177\|CRISPRCasFinder	4727118-4727153	36	CP054927	Streptomyces fulvissimus strain NA06532 plasmid unnamed1, complete sequence	456939-456974	3	0.917
NC_021177_7	7.1\|3123037\|25\|NC_021177\|CRISPRCasFinder	3123037-3123061	25	NC_010852	Amycolatopsis mediterranei plasmid pMEA100, complete sequence	19468-19492	4	0.84
NC_021177_7	7.1\|3123037\|25\|NC_021177\|CRISPRCasFinder	3123037-3123061	25	NZ_CP032230	Streptomyces seoulensis strain KCTC 9819 plasmid unnamed	42206-42230	4	0.84
NC_021177_14	14.2\|4727118\|36\|NC_021177\|CRISPRCasFinder	4727118-4727153	36	NZ_CP038146	Streptomyces sp. S501 plasmid unnamed, complete sequence	21335-21370	4	0.889
NC_021177_14	14.1\|4727057\|35\|NC_021177\|CRISPRCasFinder	4727057-4727091	35	NZ_LT703506	Mycobacterium chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera plasmid 2	203731-203765	6	0.829
NC_021177_11	11.1\|4471601\|31\|NC_021177\|CRISPRCasFinder	4471601-4471631	31	NZ_CP023068	Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence	1243658-1243688	7	0.774
NC_021177_11	11.2\|4471655\|31\|NC_021177\|CRISPRCasFinder	4471655-4471685	31	NZ_CP046573	Rhodococcus sp. WAY2 plasmid pRWAY01, complete sequence	430748-430778	7	0.774
NC_021177_14	14.2\|4727118\|36\|NC_021177\|CRISPRCasFinder	4727118-4727153	36	NZ_CP015446	Streptomyces sp. S8 plasmid unnamed, complete sequence	65411-65446	7	0.806
NC_021177_18	18.1\|4934761\|31\|NC_021177\|CRISPRCasFinder	4934761-4934791	31	MK967377	Gordonia phage MagicMan, complete genome	3312-3342	7	0.774
NC_021177_18	18.1\|4934761\|31\|NC_021177\|CRISPRCasFinder	4934761-4934791	31	NC_031255	Gordonia phage Schwabeltier, complete genome	3313-3343	7	0.774
NC_021177_11	11.1\|4471601\|31\|NC_021177\|CRISPRCasFinder	4471601-4471631	31	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	335879-335909	8	0.742
NC_021177_11	11.2\|4471655\|31\|NC_021177\|CRISPRCasFinder	4471655-4471685	31	NC_014035	Rhodobacter capsulatus SB 1003 plasmid pRCB133, complete sequence	103713-103743	8	0.742
NC_021177_11	11.2\|4471655\|31\|NC_021177\|CRISPRCasFinder	4471655-4471685	31	NZ_CP026518	Deinococcus sp. NW-56 plasmid unnamed2, complete sequence	246011-246041	8	0.742
NC_021177_14	14.3\|4727180\|35\|NC_021177\|CRISPRCasFinder	4727180-4727214	35	NZ_CP020372	Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence	428781-428815	8	0.771
NC_021177_18	18.1\|4934761\|31\|NC_021177\|CRISPRCasFinder	4934761-4934791	31	NZ_CP035515	Haematobacter massiliensis strain OT1 plasmid pOT1-5, complete sequence	99280-99310	8	0.742
NC_021177_18	18.1\|4934761\|31\|NC_021177\|CRISPRCasFinder	4934761-4934791	31	NZ_CP030127	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence	704102-704132	8	0.742
NC_021177_8	8.1\|3690977\|37\|NC_021177\|CRISPRCasFinder	3690977-3691013	37	KR080197	Mycobacterium phage FlagStaff, complete genome	20990-21026	9	0.757
NC_021177_19	19.1\|5063544\|30\|NC_021177\|PILER-CR	5063544-5063573	30	NZ_CP023000	Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-B, complete sequence	1446653-1446682	9	0.7

1. spacer 14.2|4727118|36|NC_021177|CRISPRCasFinder matches to CP054927 (Streptomyces fulvissimus strain NA06532 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.917

cagtccgccgggtcctggtccgacttctgccggggg	CRISPR spacer
cagtccgccggatcctggtccgacttctgccggttg	Protospacer
***********.*********************  *

2. spacer 7.1|3123037|25|NC_021177|CRISPRCasFinder matches to NC_010852 (Amycolatopsis mediterranei plasmid pMEA100, complete sequence) position: , mismatch: 4, identity: 0.84

acaccggacgggccggggtaggcgc	CRISPR spacer
agcccggacgggccggggtagacgg	Protospacer
*  ******************.**

3. spacer 7.1|3123037|25|NC_021177|CRISPRCasFinder matches to NZ_CP032230 (Streptomyces seoulensis strain KCTC 9819 plasmid unnamed) position: , mismatch: 4, identity: 0.84

acaccggacgggccggggtaggcgc	CRISPR spacer
ccaccgggcgggccggggttggcgg	Protospacer
 ******.*********** ****

4. spacer 14.2|4727118|36|NC_021177|CRISPRCasFinder matches to NZ_CP038146 (Streptomyces sp. S501 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.889

cagtccgccgggtcctggtccgacttctgccggggg	CRISPR spacer
cagtcagccgggtcctggtccgccttctgccggttg	Protospacer
***** **************** **********  *

5. spacer 14.1|4727057|35|NC_021177|CRISPRCasFinder matches to NZ_LT703506 (Mycobacterium chimaera strain Mycobacterium chimaera MC045 isolate Mycobacterium chimaera plasmid 2) position: , mismatch: 6, identity: 0.829

cgcaccccgaccaccggggccgccgggcagcggga-	CRISPR spacer
cccacccggaccaccggggccgcccgg-accaggac	Protospacer
* ***** **************** ** * *.***

6. spacer 11.1|4471601|31|NC_021177|CRISPRCasFinder matches to NZ_CP023068 (Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence) position: , mismatch: 7, identity: 0.774

gagacggcggcggggacacgcgtacggggag	CRISPR spacer
cggacggcggcggagacacgcgtaccaagcg	Protospacer
 .***********.*********** ..* *

7. spacer 11.2|4471655|31|NC_021177|CRISPRCasFinder matches to NZ_CP046573 (Rhodococcus sp. WAY2 plasmid pRWAY01, complete sequence) position: , mismatch: 7, identity: 0.774

ggagcggcgagcaggatccgcgtaagggcga	CRISPR spacer
cgagcggcgaggaggatccgcgtctcggtgt	Protospacer
 ********** ***********   **.*

8. spacer 14.2|4727118|36|NC_021177|CRISPRCasFinder matches to NZ_CP015446 (Streptomyces sp. S8 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.806

cagtccgccgggtcctggtccgacttctgccggggg	CRISPR spacer
cagtccgccggatcctggtcggacttcgacctgttg	Protospacer
***********.******** ****** .** *  *

9. spacer 18.1|4934761|31|NC_021177|CRISPRCasFinder matches to MK967377 (Gordonia phage MagicMan, complete genome) position: , mismatch: 7, identity: 0.774

atatgggtgcgggttcgtcctccgcgagggt	CRISPR spacer
tcttgggtgcgggttcgtcctcgccgaagtt	Protospacer
 . *******************  ***.* *

10. spacer 18.1|4934761|31|NC_021177|CRISPRCasFinder matches to NC_031255 (Gordonia phage Schwabeltier, complete genome) position: , mismatch: 7, identity: 0.774

atatgggtgcgggttcgtcctccgcgagggt	CRISPR spacer
tcttgggtgcgggttcgtcctcgccgaagtt	Protospacer
 . *******************  ***.* *

11. spacer 11.1|4471601|31|NC_021177|CRISPRCasFinder matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.742

gagacggcggcggggacacgcgtacggggag	CRISPR spacer
tgcgggccggcggggacacccgtacgggggg	Protospacer
 . . * ************ *********.*

12. spacer 11.2|4471655|31|NC_021177|CRISPRCasFinder matches to NC_014035 (Rhodobacter capsulatus SB 1003 plasmid pRCB133, complete sequence) position: , mismatch: 8, identity: 0.742

ggagcggcgagcaggatccgcgtaagggcga	CRISPR spacer
agcgcggcgagcaggatcagcgtcaggatcc	Protospacer
.* *************** **** ***..

13. spacer 11.2|4471655|31|NC_021177|CRISPRCasFinder matches to NZ_CP026518 (Deinococcus sp. NW-56 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.742

ggagcggcgagcaggatccgcgtaagggcga	CRISPR spacer
agcgcggccagcaggatccgcctaagcaggc	Protospacer
.* ***** ************ **** . *

14. spacer 14.3|4727180|35|NC_021177|CRISPRCasFinder matches to NZ_CP020372 (Candidatus Thiodictyon syntrophicum strain Cad16T plasmid pTs485, complete sequence) position: , mismatch: 8, identity: 0.771

agtgaccgagcaagctgacctccagcccgacggga	CRISPR spacer
cgtgaccgagcaagcgcacctccagcgacccggca	Protospacer
 **************  *********    *** *

15. spacer 18.1|4934761|31|NC_021177|CRISPRCasFinder matches to NZ_CP035515 (Haematobacter massiliensis strain OT1 plasmid pOT1-5, complete sequence) position: , mismatch: 8, identity: 0.742

atatgggtgcgggttcgtcctccgcgagggt	CRISPR spacer
cggacggcgcgggttcgtcctccgcgcgggg	Protospacer
  .  **.****************** ***

16. spacer 18.1|4934761|31|NC_021177|CRISPRCasFinder matches to NZ_CP030127 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.742

atatgggtgcgggttcgtcctccgcgagggt	CRISPR spacer
cggggagtgcgggttcatcctccgcgacggg	Protospacer
  . *.**********.********** **

17. spacer 8.1|3690977|37|NC_021177|CRISPRCasFinder matches to KR080197 (Mycobacterium phage FlagStaff, complete genome) position: , mismatch: 9, identity: 0.757

cacaccgccggttccgccggtcgtaccgccggtcagg	CRISPR spacer
cagcgggtccgttccgccggtcgcgccgccggtcagc	Protospacer
**    *.* *************..***********

18. spacer 19.1|5063544|30|NC_021177|PILER-CR matches to NZ_CP023000 (Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-B, complete sequence) position: , mismatch: 9, identity: 0.7

cccgtgtcgtgtgcgccggtctcgtgcgta	CRISPR spacer
tcaaggtcgtgggcgccggtctcgtgaacg	Protospacer
.* . ****** ************** ...

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1485961 : 1492642

Streptomyces_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015607663.1\|1485961_1486648_+	nucleotidyltransferase	A0A1J0GW18	Streptomyces_phage	3.2e-16	36.5
WP_015607665.1\|1486943_1487969_-	ADP-ribosylglycohydrolase family protein	A0A2D0ZND4	Rhodococcus_phage	1.1e-31	32.7
WP_015607666.1\|1487965_1488730_-	NUDIX hydrolase	A0A0E3JJF3	Streptomyces_phage	2.3e-23	49.3
WP_015607667.1\|1488726_1489806_-	AAA family ATPase	A0A2K8HHU5	Bacteriophage	9.2e-26	29.0
WP_015607668.1\|1489802_1490459_-	nicotinamide mononucleotide transporter	A0A0F6YPU8	Sinorhizobium_phage	2.7e-12	30.2
WP_015607669.1\|1490585_1491965_-	pseudouridine synthase	NA	NA	NA	NA
WP_015607670.1\|1491964_1492642_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	1.9e-08	29.7

DBSCAN-SWA_2

3441978 : 3490347

Freshwater_phage(12.5%)

holin,tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015609321.1\|3441978_3442962_-\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_164711284.1\|3443233_3444076_-	hypothetical protein	NA	NA	NA	NA
WP_043972439.1\|3444309_3445221_+	A/G-specific adenine glycosylase	NA	NA	NA	NA
WP_015609324.1\|3445376_3446102_+	SigE family RNA polymerase sigma factor	NA	NA	NA	NA
WP_032775725.1\|3446212_3446872_+	hypothetical protein	NA	NA	NA	NA
WP_015609326.1\|3446967_3447681_+	response regulator transcription factor	NA	NA	NA	NA
WP_015609327.1\|3447677_3449015_+	HAMP domain-containing protein	NA	NA	NA	NA
WP_015609328.1\|3449215_3449929_-	M23 family metallopeptidase	A0A1B0XUH3	Freshwater_phage	5.3e-22	45.8
WP_015609329.1\|3450386_3450770_+	hypothetical protein	NA	NA	NA	NA
WP_078618865.1\|3450838_3453745_+\|protease	serine protease	NA	NA	NA	NA
WP_015609331.1\|3453824_3456353_-\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	1.2e-132	41.0
WP_015609332.1\|3456802_3457393_+	hypothetical protein	NA	NA	NA	NA
WP_003968298.1\|3457371_3457707_-	Lsr2 family protein	A0A0K1YA95	Streptomyces_phage	9.9e-11	38.5
WP_078618867.1\|3457861_3458359_-	amino-acid N-acetyltransferase	NA	NA	NA	NA
WP_015609334.1\|3458441_3458876_-	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_015609335.1\|3459008_3459188_-	hypothetical protein	NA	NA	NA	NA
WP_015609336.1\|3459269_3459863_-	hypothetical protein	NA	NA	NA	NA
WP_015609337.1\|3460025_3460823_-	type III pantothenate kinase	NA	NA	NA	NA
WP_015609338.1\|3460822_3461881_-	carboxylating nicotinate-nucleotide diphosphorylase	NA	NA	NA	NA
WP_015609339.1\|3461950_3463645_-	L-aspartate oxidase	NA	NA	NA	NA
WP_043974511.1\|3463641_3464637_-	pantoate--beta-alanine ligase	NA	NA	NA	NA
WP_015609341.1\|3464720_3465662_-	DUF2520 domain-containing protein	NA	NA	NA	NA
WP_015609342.1\|3465831_3466986_+	Aromatic amino acid beta-eliminating lyase/threonine aldolase	NA	NA	NA	NA
WP_015609343.1\|3467029_3467230_-	hypothetical protein	NA	NA	NA	NA
WP_015609344.1\|3467333_3468446_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_015609345.1\|3468466_3469141_-	response regulator transcription factor	NA	NA	NA	NA
WP_015609346.1\|3469195_3470398_-	sensor histidine kinase	NA	NA	NA	NA
WP_015609347.1\|3470494_3471481_+	DUF185 domain-containing protein	NA	NA	NA	NA
WP_043972458.1\|3471522_3472665_+	NADH-quinone oxidoreductase subunit D	NA	NA	NA	NA
WP_164711285.1\|3472692_3473967_-	hypothetical protein	NA	NA	NA	NA
WP_015609350.1\|3474067_3475036_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_015609351.1\|3475097_3475772_-	ABC transporter permease	NA	NA	NA	NA
WP_015609352.1\|3475775_3476576_-	ABC transporter permease	NA	NA	NA	NA
WP_015609353.1\|3476716_3477889_+\|holin	betaine/proline/choline family ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.2e-23	33.0
WP_015609354.1\|3477994_3479116_-	esterase	NA	NA	NA	NA
WP_078618682.1\|3479316_3481092_+	DUF2156 domain-containing protein	NA	NA	NA	NA
WP_164711286.1\|3481122_3481983_+	dihydropteroate synthase	A0A0B5J4J5	Pandoravirus	6.7e-19	30.5
WP_015609357.1\|3481979_3482453_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_003968268.1\|3482665_3483025_+	dihydroneopterin aldolase	NA	NA	NA	NA
WP_015609358.1\|3483021_3483633_+	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_015609359.1\|3483695_3484187_+	DUF3180 domain-containing protein	NA	NA	NA	NA
WP_015609360.1\|3484266_3484872_-	GTP cyclohydrolase I FolE	E7DN69	Pneumococcus_phage	3.0e-42	51.7
WP_015609361.1\|3485035_3487093_-\|protease	ATP-dependent zinc metalloprotease FtsH	G8DDJ2	Micromonas_pusilla_virus	1.6e-106	44.8
WP_030593143.1\|3487261_3487801_-	hypoxanthine phosphoribosyltransferase	A0A1V0SEQ1	Hokovirus	2.3e-09	30.8
WP_015609363.1\|3487901_3489023_-\|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_043972462.1\|3489210_3490347_-\|protease	zinc-dependent metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_3

4133486 : 4183692

Streptomyces_phage(80.0%)

terminase,transposase,integrase,tail,portal

attL 4152401:4152418|attR 4180299:4180316

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_123060222.1\|4133486_4134089_+\|transposase	transposase	NA	NA	NA	NA
WP_106960118.1\|4134353_4135019_+	restriction endonuclease	NA	NA	NA	NA
WP_164711289.1\|4134981_4136577_+	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_015609934.1\|4138354_4138819_-	NUDIX domain-containing protein	NA	NA	NA	NA
WP_015609935.1\|4138837_4139617_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_015609936.1\|4139804_4140584_-	hypothetical protein	NA	NA	NA	NA
WP_031122608.1\|4141022_4141337_+	hypothetical protein	NA	NA	NA	NA
WP_043972641.1\|4141546_4142779_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_015609939.1\|4142775_4143816_+	DUF35 domain-containing protein	NA	NA	NA	NA
WP_015609940.1\|4143817_4144861_+	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_015609941.1\|4144857_4145313_+	MaoC family dehydratase	NA	NA	NA	NA
WP_015609942.1\|4145309_4146476_+	lipid-transfer protein	NA	NA	NA	NA
WP_015609943.1\|4146656_4147223_+	SigE family RNA polymerase sigma factor	NA	NA	NA	NA
WP_015609944.1\|4147358_4149011_+	long-chain fatty acid--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	1.3e-23	24.4
4152401:4152418	attL	NA	NA	NA	NA
WP_015609947.1\|4153675_4154227_-	secreted protein	NA	NA	NA	NA
WP_015609948.1\|4155072_4156266_-\|integrase	site-specific integrase	A0A0A7S2C0	Mycobacterium_phage	2.0e-45	33.7
WP_106960120.1\|4156370_4156709_-	hypothetical protein	NA	NA	NA	NA
WP_015609950.1\|4156963_4157191_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_015609951.1\|4157187_4157400_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015609952.1\|4157490_4157838_+	hypothetical protein	NA	NA	NA	NA
WP_043974619.1\|4157858_4158482_+	hypothetical protein	NA	NA	NA	NA
WP_015609954.1\|4158478_4158844_+	ATP synthase subunit I	NA	NA	NA	NA
WP_015609955.1\|4158840_4159071_+	hypothetical protein	A0A142K669	Streptomyces_phage	2.9e-14	58.2
WP_015609956.1\|4159067_4159532_+	hypothetical protein	NA	NA	NA	NA
WP_015609957.1\|4159553_4161065_+	hypothetical protein	NA	NA	NA	NA
WP_015609958.1\|4161061_4161376_+	hypothetical protein	NA	NA	NA	NA
WP_106960238.1\|4161402_4161618_+	hypothetical protein	NA	NA	NA	NA
WP_015609960.1\|4161614_4162457_+	DNA adenine methylase	R4JMC6	Burkholderia_phage	1.1e-42	40.1
WP_015609961.1\|4162453_4162768_+	hypothetical protein	NA	NA	NA	NA
WP_043972648.1\|4162773_4163190_+	hypothetical protein	NA	NA	NA	NA
WP_015609963.1\|4163255_4164005_+	hypothetical protein	A0A142K676	Streptomyces_phage	4.4e-35	39.9
WP_015609964.1\|4164073_4164331_-	hypothetical protein	NA	NA	NA	NA
WP_015609965.1\|4164472_4164823_+	hypothetical protein	NA	NA	NA	NA
WP_015609966.1\|4164822_4164984_+	hypothetical protein	NA	NA	NA	NA
WP_015609967.1\|4165040_4165907_+	hypothetical protein	A0A0M5M0U6	Streptomyces_phage	1.2e-31	43.7
WP_015609968.1\|4165903_4166554_+	hypothetical protein	NA	NA	NA	NA
WP_015609969.1\|4166567_4167014_+	hypothetical protein	NA	NA	NA	NA
WP_015609970.1\|4167015_4167867_+	hypothetical protein	NA	NA	NA	NA
WP_015609972.1\|4168064_4168220_+	hypothetical protein	NA	NA	NA	NA
WP_043972654.1\|4168276_4168495_+	hypothetical protein	NA	NA	NA	NA
WP_015609974.1\|4168667_4168919_+	MerR family transcriptional regulator	A0A142K678	Streptomyces_phage	7.9e-21	66.2
WP_015609975.1\|4169112_4169310_+	hypothetical protein	NA	NA	NA	NA
WP_043972656.1\|4169680_4169908_+	hypothetical protein	NA	NA	NA	NA
WP_015609977.1\|4170033_4170624_+\|terminase	P27 family phage terminase small subunit	A0A2H5BLR0	Streptomyces_phage	6.1e-40	49.5
WP_043972660.1\|4170643_4172335_+\|terminase	terminase large subunit	A0A2H5BLT3	Streptomyces_phage	4.0e-209	64.0
WP_106960123.1\|4172348_4173827_+\|portal	phage portal protein	A0A2H5BLQ6	Streptomyces_phage	1.5e-122	48.8
WP_106960239.1\|4173925_4174867_+	hypothetical protein	A0A2H5BLR1	Streptomyces_phage	4.2e-75	55.6
WP_015609981.1\|4174942_4175644_+	hypothetical protein	D7NW52	Streptomyces_phage	1.5e-13	38.2
WP_015609982.1\|4175686_4176634_+	Major structural phage protein	A0A2H5BLW0	Streptomyces_phage	1.4e-131	76.1
WP_015609983.1\|4176656_4176983_+	hypothetical protein	NA	NA	NA	NA
WP_015609984.1\|4176985_4177540_+	hypothetical protein	NA	NA	NA	NA
WP_043974627.1\|4177539_4177881_+	hypothetical protein	NA	NA	NA	NA
WP_015609986.1\|4177877_4178216_+	hypothetical protein	NA	NA	NA	NA
WP_106960124.1\|4178116_4178623_+	hypothetical protein	NA	NA	NA	NA
WP_015609988.1\|4178658_4179330_+	hypothetical protein	A0A0K1Y595	Streptomyces_phage	4.5e-55	54.4
WP_052334481.1\|4179374_4179761_+	hypothetical protein	NA	NA	NA	NA
WP_106960125.1\|4179832_4180186_+	hypothetical protein	NA	NA	NA	NA
WP_015609991.1\|4180188_4183692_+\|tail	phage tail tape measure protein	A0A2H5BLS1	Streptomyces_phage	3.1e-179	43.4
4180299:4180316	attR	NA	NA	NA	NA

DBSCAN-SWA_4

4923905 : 4941567

Streptomyces_phage(72.73%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015610696.1\|4923905_4927391_+	DNA-directed RNA polymerase subunit beta	G8DH04	Emiliania_huxleyi_virus	2.0e-29	21.9
WP_015610697.1\|4927521_4931421_+	DNA-directed RNA polymerase subunit beta'	A0A2I7QNZ7	Vibrio_phage	4.9e-53	27.3
WP_003966993.1\|4931512_4931773_-	hypothetical protein	A0A1J0MCA5	Streptomyces_phage	7.6e-27	72.3
WP_015610698.1\|4931769_4931997_-	hypothetical protein	A0A142K647	Streptomyces_phage	4.3e-18	67.6
WP_015610699.1\|4932016_4933024_-	N-acetylmuramoyl-L-alanine amidase	A0A2P1N078	Streptomyces_phage	3.1e-92	56.9
WP_015610700.1\|4933136_4934597_-	hypothetical protein	A0A1V0E627	Streptomyces_phage	4.8e-25	52.8
WP_015610701.1\|4934908_4935625_-	hypothetical protein	A0A1J0MC40	Streptomyces_phage	1.6e-37	40.8
WP_015610702.1\|4935628_4936735_-	hypothetical protein	A0A1J0MCX4	Streptomyces_phage	7.8e-105	53.5
WP_015610703.1\|4936805_4938008_-	hypothetical protein	K4HYZ6	Streptomyces_phage	4.7e-55	52.9
WP_015610704.1\|4938060_4939041_-	hypothetical protein	A0A1J0MBX9	Streptomyces_phage	1.1e-54	43.8
WP_015610705.1\|4939087_4940371_-	hypothetical protein	NA	NA	NA	NA
WP_015610706.1\|4940367_4941567_-	hypothetical protein	F8UBC8	Clostridium_phage	6.2e-15	48.4

DBSCAN-SWA_5

5828667 : 5877037

Bacillus_phage(40.0%)

plate,tail,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_106960267.1\|5828667_5829765_-\|transposase	transposase	NA	NA	NA	NA
WP_015611473.1\|5830200_5831151_+	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	NA	NA	NA	NA
WP_015611474.1\|5831195_5832233_+	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_015611475.1\|5832247_5834095_+	1-deoxy-D-xylulose-5-phosphate synthase	NA	NA	NA	NA
WP_015611476.1\|5834091_5835273_+	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	NA	NA	NA	NA
WP_164711297.1\|5835719_5835893_-	hypothetical protein	NA	NA	NA	NA
WP_043973398.1\|5835941_5838026_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_015611478.1\|5838099_5839062_-	UbiA family prenyltransferase	NA	NA	NA	NA
WP_015611479.1\|5839070_5840474_-	NDP-hexose 2,3-dehydratase-like protein	NA	NA	NA	NA
WP_015611480.1\|5840470_5841454_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	9.8e-67	41.9
WP_015611481.1\|5841450_5842506_-	glucose-1-phosphate thymidylyltransferase	A0A127AW70	Bacillus_phage	3.1e-18	29.1
WP_015611482.1\|5842737_5846052_-	ATPase-like protein	NA	NA	NA	NA
WP_015611483.1\|5846195_5846780_+	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_015611485.1\|5848670_5849888_+	class I SAM-dependent methyltransferase	A0A1V0SJ83	Klosneuvirus	7.5e-32	24.0
WP_015611486.1\|5849902_5850682_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_164711298.1\|5850731_5852078_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_015611488.1\|5852149_5853256_+	DUF1205 domain-containing protein	NA	NA	NA	NA
WP_015611489.1\|5853302_5853881_+	dTDP-4-dehydrorhamnose 3,5-epimerase family protein	NA	NA	NA	NA
WP_015611490.1\|5853880_5854849_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_015611491.1\|5854927_5855866_-	DUF2236 domain-containing protein	NA	NA	NA	NA
WP_015611492.1\|5855978_5857952_-	FAD/NAD(P)-binding protein	NA	NA	NA	NA
WP_015611493.1\|5857951_5859517_-	acyl-CoA synthetase	NA	NA	NA	NA
WP_015611494.1\|5859595_5860135_-	SRPBCC family protein	NA	NA	NA	NA
WP_015611495.1\|5860407_5862048_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_015611496.1\|5862141_5863035_-	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_106960140.1\|5863289_5864036_-	zinc ribbon domain-containing protein	NA	NA	NA	NA
WP_015611498.1\|5864760_5865348_-\|tail	phage tail protein I	NA	NA	NA	NA
WP_015611499.1\|5865344_5867306_-\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_015611500.1\|5867305_5867743_-	GPW/gp25 family protein	E3SNK6	Prochlorococcus_phage	1.1e-09	31.6
WP_015611501.1\|5867739_5868057_-	PAAR repeat-containing protein	NA	NA	NA	NA
WP_015611502.1\|5868163_5869933_-	VgrG-related protein	NA	NA	NA	NA
WP_015611503.1\|5869929_5870652_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_015611504.1\|5870689_5871115_-\|tail	phage tail protein	NA	NA	NA	NA
WP_052334485.1\|5871192_5871765_-	hypothetical protein	NA	NA	NA	NA
WP_078618761.1\|5872483_5873095_+	hypothetical protein	NA	NA	NA	NA
WP_164711299.1\|5873959_5874112_+	hypothetical protein	NA	NA	NA	NA
WP_015611507.1\|5874492_5874996_-	hypothetical protein	NA	NA	NA	NA
WP_007457189.1\|5874992_5875433_-\|tail	phage tail protein	NA	NA	NA	NA
WP_015611508.1\|5875495_5877037_-\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	2.5e-69	35.2

DBSCAN-SWA_6

6095492 : 6129077

Streptomyces_phage(100.0%)

tail,terminase,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015611698.1\|6095492_6098885_-	hypothetical protein	D7NW64	Streptomyces_phage	2.2e-158	36.3
WP_015611699.1\|6098901_6102096_-\|tail	phage tail tape measure protein	A0A2H5BLS1	Streptomyces_phage	1.5e-79	43.9
WP_015611700.1\|6102296_6102812_-	hypothetical protein	NA	NA	NA	NA
WP_015611701.1\|6102811_6103297_-	hypothetical protein	NA	NA	NA	NA
WP_015611702.1\|6103305_6103740_-	hypothetical protein	NA	NA	NA	NA
WP_015611703.1\|6103736_6104084_-	hypothetical protein	A0A1J0MCD0	Streptomyces_phage	2.9e-37	69.9
WP_106960270.1\|6104080_6104401_-	hypothetical protein	A0A1J0MBV0	Streptomyces_phage	4.8e-31	64.2
WP_015611705.1\|6104394_6104781_-	hypothetical protein	A0A1J0MCI1	Streptomyces_phage	1.1e-40	71.3
WP_015611707.1\|6104939_6105797_-\|capsid	N4-gp56 family major capsid protein	A0A1J0MCF0	Streptomyces_phage	6.0e-129	81.8
WP_052334465.1\|6105864_6106671_-	hypothetical protein	A0A1J0MBT9	Streptomyces_phage	1.2e-22	45.4
WP_015611709.1\|6106778_6106952_-	hypothetical protein	A0A1J0MC36	Streptomyces_phage	2.1e-12	68.8
WP_106960141.1\|6106954_6108781_-\|capsid	phage capsid protein	K4IBG1	Streptomyces_phage	8.7e-210	61.2
WP_106960142.1\|6109134_6110613_-\|capsid	phage capsid protein	A0A1J0MCN7	Streptomyces_phage	1.5e-159	59.7
WP_015611712.1\|6110615_6110807_-	hypothetical protein	NA	NA	NA	NA
WP_015611713.1\|6110819_6112052_-\|terminase	PBSX family phage terminase large subunit	A0A1V0E630	Streptomyces_phage	3.3e-144	60.0
WP_043973528.1\|6112041_6112584_-	helix-turn-helix domain-containing protein	A0A1J0MCI5	Streptomyces_phage	2.1e-26	44.4
WP_164711302.1\|6113607_6114285_-	hypothetical protein	A0A1J0MC67	Streptomyces_phage	7.3e-13	47.0
WP_164711303.1\|6114411_6114753_-	hypothetical protein	A0A1J0MD87	Streptomyces_phage	2.8e-13	65.4
WP_106960271.1\|6115522_6116359_-	hypothetical protein	A0A1J0MCS6	Streptomyces_phage	1.3e-72	57.5
WP_015611719.1\|6116382_6116931_-	hypothetical protein	NA	NA	NA	NA
WP_015611720.1\|6116930_6117077_-	hypothetical protein	NA	NA	NA	NA
WP_015611721.1\|6117203_6117440_-	hypothetical protein	NA	NA	NA	NA
WP_015611722.1\|6117436_6117736_-	hypothetical protein	NA	NA	NA	NA
WP_015611723.1\|6117732_6117912_-	hypothetical protein	NA	NA	NA	NA
WP_015611724.1\|6117908_6119186_-	hypothetical protein	NA	NA	NA	NA
WP_015611725.1\|6119270_6119753_-	single-stranded DNA-binding protein	A0A1J0MCM0	Streptomyces_phage	4.1e-50	67.3
WP_015611726.1\|6119752_6120223_-	HNH endonuclease	A0A1J0MCN4	Streptomyces_phage	4.1e-39	62.6
WP_164711304.1\|6120350_6120521_-	hypothetical protein	NA	NA	NA	NA
WP_015611727.1\|6120517_6120814_-	hypothetical protein	A0A1J0MCR5	Streptomyces_phage	6.7e-19	57.6
WP_015611728.1\|6120810_6121494_-	hypothetical protein	K4IBK0	Streptomyces_phage	6.0e-31	49.6
WP_015611729.1\|6121490_6122423_-	hypothetical protein	A0A1J0MCR8	Streptomyces_phage	1.6e-55	52.4
WP_015611730.1\|6122506_6122782_-	hypothetical protein	NA	NA	NA	NA
WP_015611731.1\|6122778_6123009_-	hypothetical protein	A0A1J0MCH6	Streptomyces_phage	6.5e-14	60.6
WP_015611732.1\|6123005_6123380_-	hypothetical protein	NA	NA	NA	NA
WP_015611734.1\|6124159_6125311_-	hypothetical protein	A0A1J0MBW0	Streptomyces_phage	1.0e-70	63.4
WP_015611735.1\|6125307_6125685_-	hypothetical protein	A0A1J0MC56	Streptomyces_phage	8.5e-27	59.5
WP_015611736.1\|6125681_6126062_-	hypothetical protein	NA	NA	NA	NA
WP_015611737.1\|6126131_6126317_-	hypothetical protein	A0A1J0MCC6	Streptomyces_phage	2.9e-12	72.1
WP_015611738.1\|6126313_6126523_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_043974913.1\|6126805_6127207_+	helix-turn-helix domain-containing protein	A0A1J0MCR0	Streptomyces_phage	3.8e-25	49.6
WP_015611740.1\|6127230_6127434_+	hypothetical protein	NA	NA	NA	NA
WP_015611741.1\|6127430_6129077_+	recombinase family protein	K4I054	Streptomyces_phage	2.0e-144	51.3

DBSCAN-SWA_7

7820644 : 7851178

Paenibacillus_phage(33.33%)

integrase,transposase,protease

attL 7835454:7835470|attR 7854122:7854138

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015613116.1\|7820644_7821532_+\|protease	trypsin-like serine protease	NA	NA	NA	NA
WP_015613117.1\|7821680_7822586_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_015613118.1\|7822976_7823678_-	type 1 glutamine amidotransferase domain-containing protein	NA	NA	NA	NA
WP_015613119.1\|7824000_7824333_-	hypothetical protein	NA	NA	NA	NA
WP_015613120.1\|7824342_7826979_-	DNRLRE domain-containing protein	A0A2I7SCF1	Paenibacillus_phage	4.7e-15	34.4
WP_015613122.1\|7828760_7829156_-	hypothetical protein	NA	NA	NA	NA
WP_015612815.1\|7829448_7829934_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015613123.1\|7829897_7830515_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_015613124.1\|7831013_7831661_-	hypothetical protein	NA	NA	NA	NA
WP_015613126.1\|7832314_7833538_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_015613128.1\|7834176_7834416_-	hypothetical protein	NA	NA	NA	NA
WP_015613129.1\|7834593_7834938_-	hypothetical protein	NA	NA	NA	NA
7835454:7835470	attL	NA	NA	NA	NA
WP_043973986.1\|7835807_7836290_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_015613131.1\|7836386_7837076_+	hypothetical protein	NA	NA	NA	NA
WP_015613132.1\|7837221_7838139_+	TIGR03619 family F420-dependent LLM class oxidoreductase	NA	NA	NA	NA
WP_078618810.1\|7838196_7838766_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_015613134.1\|7838938_7839253_+	cupin domain-containing protein	NA	NA	NA	NA
WP_015613135.1\|7839347_7840070_+	carbon-nitrogen hydrolase family protein	NA	NA	NA	NA
WP_015613136.1\|7840078_7840303_-	hypothetical protein	NA	NA	NA	NA
WP_015613137.1\|7840506_7841316_-	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_015613138.1\|7841407_7843060_-	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_078618928.1\|7843482_7843782_+\|transposase	transposase	NA	NA	NA	NA
WP_015613139.1\|7843778_7844330_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_167336724.1\|7844262_7845600_-	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_078618814.1\|7845983_7846502_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_164711316.1\|7846736_7847075_+	hypothetical protein	NA	NA	NA	NA
WP_015613143.1\|7847506_7847797_-	hypothetical protein	NA	NA	NA	NA
WP_043973995.1\|7848253_7848484_-	hypothetical protein	NA	NA	NA	NA
WP_015613146.1\|7848658_7849126_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_015613147.1\|7849228_7850443_+	amidohydrolase family protein	NA	NA	NA	NA
WP_106960302.1\|7850476_7850611_-	hypothetical protein	A0A1B3AZE5	Gordonia_phage	5.3e-08	66.7
WP_106960166.1\|7850632_7851178_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.5e-45	54.1
7854122:7854138	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_021177

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection