CRISPRimmunity

Please click to download your results

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021191	Actinoplanes sp. N902-109, complete genome	21 crisprs	csa3,cas3,DEDDh,WYL,Cas9_archaeal,RT,cas4,DinG	1	12	3	1

Results visualization

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_021191_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_1

202199-202331

Orphan

Consensus_repeat	Method
CGGCGAGGGCCATGAGCGCATGCGAAAGGAAGGCTCAGCATGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_1

>merge|NC_021191|1|202199-202331|CRISPRCasFinder
CGGCGAGGGCCATGAGCGCATGCGAAAGGAAGGCTCAGCATGAGCGACTGCACCGAGCTGCGCCTTGCGGGGGCGGCGGACGGCCGTTGCGGCGAGGGCCATGAGCGCATGCGAAAGGACGGCTCAGCATGAG

>NC_021191|1|1|202199-202331|CRISPRCasFinder
CGGCGAGGGCCATGAGCGCATGCGAAAGGAAGGCTCAGCATGAG	CGACTGCACCGAGCTGCGCCTTGCGGGGGCGGCGGACGGCCGTTG
CGGCGAGGGCCATGAGCGCATGCGAAAGGACGGCTCAGCATGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015618261.1\|205708_206824_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|283431
NC_021191.1\|WP_063642940.1\|210092_211187_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379079
NC_021191.1\|WP_015618254.1\|195442_196204_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NC_021191.1\|WP_157408188.1\|189259_190090_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_084503982.1\|211983_213477_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270916
NC_021191.1\|WP_015618269.1\|213500_214394_-\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|214519
NC_021191.1\|WP_015618257.1\|198546_202152_+\|DUF4132-domain-containing-protein	unknown	unknown	gnl\|CDD\|379270
NC_021191.1\|WP_015618250.1\|190157_191558_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NC_021191.1\|WP_041833060.1\|182559_183408_+\|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl\|CDD\|239550
NC_021191.1\|WP_015618259.1\|196284_196944_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_021191.1\|WP_015618260.1\|203456_205712_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618251.1\|191554_192358_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_021191.1\|WP_015618255.1\|196931_198164_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_021191.1\|WP_015618252.1\|192534_193083_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618263.1\|208825_210028_-\|fibronectin-type-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|380075
NC_021191.1\|WP_051167223.1\|211280_212003_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618253.1\|193214_195440_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NC_021191.1\|WP_015618262.1\|206876_208829_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_157408189.1\|215523_216474_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|376574
NC_021191.1\|WP_084503983.1\|215347_215569_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015618261.1\|205708_206824_+\|VWA-domain-containing-protein	gnl\|CDD\|283431	pfam05762, VWA_CoxE, VWA domain containing CoxE-like protein. This family is annotated by SMART as containing a VWA (von Willebrand factor type A) domain. The exact function of this family is unknown. It is found as part of a CO oxidising (Cox) system operon is several bacteria.	1.95567e-43
NC_021191.1\|WP_015618254.1\|195442_196204_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.39945e-107
NC_021191.1\|WP_084503982.1\|211983_213477_+\|hypothetical-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.80371e-26
NC_021191.1\|WP_063642940.1\|210092_211187_-\|hypothetical-protein	gnl\|CDD\|379079	pfam13229, Beta_helix, Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	7.71871e-05
NC_021191.1\|WP_015618250.1\|190157_191558_-\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	4.1743e-136
NC_021191.1\|WP_041833060.1\|182559_183408_+\|Rieske-2Fe-2S-domain-containing-protein	gnl\|CDD\|239550	cd03467, Rieske, Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. The Rieske domain can be divided into two subdomains, with an incomplete six-stranded, antiparallel beta-barrel at one end, and an iron-sulfur cluster binding subdomain at the other. The Rieske iron-sulfur center contains a [2Fe-2S] cluster, which is involved in electron transfer, and is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs. In RO systems, the N-terminal Rieske domain of the alpha subunit acts as an electron shuttle that accepts electrons from a reductase or ferredoxin component and transfers them to the mononuclear iron in the alpha subunit C-terminal domain to be used for catalysis.	1.29266e-20
NC_021191.1\|WP_015618259.1\|196284_196944_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.79827e-45
NC_021191.1\|WP_015618251.1\|191554_192358_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	9.92379e-24
NC_021191.1\|WP_015618255.1\|196931_198164_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	5.62887e-37
NC_021191.1\|WP_015618257.1\|198546_202152_+\|DUF4132-domain-containing-protein	gnl\|CDD\|379270	pfam13569, DUF4132, Domain of unknown function (DUF4132). This domain might be involved in the biosynthesis of the molybdopterin cofactor in E.coli.	5.18073e-73
NC_021191.1\|WP_015618263.1\|208825_210028_-\|fibronectin-type-III-domain-containing-protein	gnl\|CDD\|380075	pfam17957, Big_7, Bacterial Ig domain. This entry represents a bacterial ig-like domain that is found in glycosyl hydrolase enzymes.	1.70975e-06
NC_021191.1\|WP_015618253.1\|193214_195440_-\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	2.91927e-12
NC_021191.1\|WP_015618269.1\|213500_214394_-\|CHAP-domain-containing-protein	gnl\|CDD\|214519	smart00108, B_lectin, Bulb-type mannose-specific lectin.	3.61091e-16
NC_021191.1\|WP_157408189.1\|215523_216474_-\|ISL3-family-transposase	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	8.11631e-21
NC_021191.1\|WP_084503983.1\|215347_215569_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.78139e-08

>NC_021191.1|WP_015618257.1|198546_202152_+|DUF4132-domain-containing-protein
MRRFEFVEGGSAKFWEVGRDGSEVTVRWGRVGTTGQSKVKDFADPASAAAHETKLVAEKTKKGYEETTAGPAAAAPPSPPAAQTVADEDTFVFPSGWFRHRIARRGSSGTVAFTPNPKARSIVDAQMTRMPGQVAKILQAPTTDLAVARQATAWRLGQPEATPLGAAAVAAATEVGNWRTRDELVNFADVWIAGHGLRFAAVAATELMSLKVTDNDRPSNPHYNAQTQQWGVRHMWPGEDRQGYYLDLGMEVTLRVRQALAAASADDYAAVVADLTPYRAAHPDARAATSVLVPTQRDWVEEDIAATVAAGNGYLGAFLLAAAGSRADVDALVPVIETWVAVRSLPLIATLIDGIGPEAATALFHWLDKEAGDADSQRRLLSALAVLPGDDVMQGLIDRVDEKYVPPALLDAAARFPVRAMRLLAGSAGKRTVADLLRGHVLAHPELVDRVLPHLDAAAVGRIEAIVGDASALRVAPESALPPVLVDPPWQHRVKAAKPVVIAGLASTAPATFDWAEGERESWATAHWHSYYRNATDTWEQRLHRIKSGNGHYWEAPSFFVEGPEELVRPLLSEWRPDDVWGAGDWMRLVVARFELAALPMTLTVARRSPAEVAPLLAPYFSAEIALQMAEWYARLKTVRATALAWLLRHPAEAARALVPAALGKPGVPRRQAENALLALHHNGQGEAVQAAAQTYGAEAGAAIRTLLETDPLSLLPARMPAAPAWAAPGLLPPVKLRDGSGVLPVEAVTNLITMLAISRLDDPYAGLEPVRAACDPVSLAEFGWGLFQRWQMSGAPSKESWVLDTLGLIGDDETVRLLSPLVLTWPGEGGHAKAVAGLSVLAGIGTDVALMHLHGIAQRAKFKGLKTAAQQKMDEVAAGLGLSAEQLADRLVPDLGLDADGSMRLDYGPRQFTVGFDEQLRPYVADSAGKRLKALPKPGARDDEELAPAAYRTFSGLKKDVRTIAADQIRRLERAMVSGRRWTGAEFRQLFVAHPLLWHIVRRLVWGCFDESGALIGAIRVAEDRSFATVDDDETTVADDATVGVVHPLQLGGSLPDWVEVFADYEILQPFPQLSRPTFGLTPAEAASNRLSRFEGITVPTGRVIGLERRGWRREEPQDAGIQGAIELAVDEKRQVVIDLDPGIAVGAMDIFPDQKLDRIYLWNGVGSRWGNRAESAVALSELDAITVSEVIRDLTEITA
>NC_021191.1|WP_015618255.1|196931_198164_-|sensor-histidine-kinase
MVRRYLRERVRASVDALEHLVGGLGTALLAMGALLWLLIVAVLCLNAVGLLLAPGALKALRSVANRERGRLTRWGPPVVEPAPLPEGLKAMLRDDTVRRELAWVLLHGTFGFVIGVFGLSLPLQAVQDATYPLWFRAVDGSQGGPGLLWWPVRDVVDALGVGLMGLVWIAIAVGLGPAMARWQAAPGRWLLKPTGDVDLSLRIAELTSTRAAALDAHATELRRIERSLHDGTQNRLVAVNVLLGAARRALTRDPATAEEILARAQDAAEQALSELRTVVRGILPPVLADRGLAGALTGLAGSSPVPCTVDVDVPGRCAASVEATAYFVVAEALTNVTKHSGASRATVTVRREGDRLLLRVDDDGHGGADETGGSGIGGIRRRVEAYDGRLTLTSPPGGPTSMQVELPCGS
>NC_021191.1|WP_015618259.1|196284_196944_-|response-regulator-transcription-factor
MRIVIAEDEPLLREGLALLLRAESLDVAATAEDPGSFLAAVEKHDPDVAIVDVRMPPTHTDEGIVAAVEARRRKPGLAVLVLSAYVEQAFATDLLAGGAAKLGYLLKERVGRVEEFLDALHRVAGGGTAIDPEVVGQLLTRTRPDSGLERLSARERDVLAAMAEGLGNTAIAERLFVTEGAVHKHIRSIFAKLDLAPSDQADRRVTAVLRYLEDVQRKG
>NC_021191.1|WP_015618254.1|195442_196204_-|ABC-transporter-ATP-binding-protein
MNTQRIEAVVRVEQLTRIYQTGGQPVTALTGVDAAFYRGTFTAVMGPSGSGKSTLLQACAGLDRPTSGRVWIGDTELSRLSETKLTKLRRNRIGFVFQAFNLIGALTVEDNILLPLRLAGVRPDRAWITEVVDRVGLADRLQYRPAALSGGQQQRVAIARALATRPEVIFCDEPTGALDTQTAADVLALLRSVVDAHGQTVVMVTHDPVAASYADRVVVLADGHIRRDLPQPGAERIAEQLAALGRQRVAQGV
>NC_021191.1|WP_015618253.1|193214_195440_-|ABC-transporter-permease
MLKLAALTLRHRAGSAVATLLALAAGVMILLSMGTLVESGLRYQPHPVRYEKSAVVVANRDITFTTKEFDGDVSRDTVPLPEGGTVPAELIAEIRAVPGITGVTADDSGTHPGRVEAIAVATSDPAAVAAVQRLATAAGVKAYTGKDRGLLEQPDGAATRDLLIAIGASFGGYVGLLIVFVVAGTVGLAVRHRRRDLALLRAVAATPGQVRRMIVLEAALMGVIAAVLGVPAGLLATSWVHDQLVHRGFLAADFPIVTGVFSAPAAVLLIVLVAVCSALIAARRVTGIRPAEALGEAAIEPPASSKVRLIAGVLTLAGAGGSSTVAVSTGGETALTGAIGMLYLFVLGVALLAPWINTLGARLLTPALRRVFGTSGYLAGANLRANARGMSAVLTALVLSIGFGCSVWFLQDNLQRGTVTQRADGTLADRALIAPAGLPGTVAGEVQAVPGVQAVTPVRRTSVLVKLLDSGEQVEAQAVDPTTATETIDPQVREGSLRDLDDHSIAVSRLQAGSHRWKVGDDVKLWLGDGTPVTMRVAAIYDRGLGFGDVMLTTHAVEGHTRSPLDDQLLIRSKPGASVDSALGSIAARYPGASVVGADQLSGRLAKDLALSAWLNKLLIGVMVGYAALAAANTMVMAALSRRRELALLRLVGVTRRQIKNMVHAEQAGLLGVALVIGAAIAAVTLTLVVYALTGDPLPYIPPLGWAAVLGGTTLLALVATVLPVGRLLRAAPLEHMGSKE
>NC_021191.1|WP_015618252.1|192534_193083_-|hypothetical-protein
MTSDPASARLRVFTQDQTDAGWRSMSLLARFIQRGGHPAPVAPTIKLRSSEKQYGAFLTDLLTYQSDGVFTGGGIFWRGAATSAEPGWEHRGRHAATITNQRLIIEADDHRADYDFRDLIMVQPNPLEWSVNLYFQGHPPLMLSGPWVPWMTVVMCAELYGSPWPPGSDTPVTAMCDNTGQG
>NC_021191.1|WP_015618251.1|191554_192358_-|alpha/beta-hydrolase
MPTCTTSDGVSLHYTDEGSGSPIVLIPGFAASVETWELQRGALTEAGHRVLALDRRGHGGSESTTWGLRMSRHGKDLHNFLATLDLSDVVLVGGSMGAGSIWAYCDLFGDGRARGIVTVDQTPRMLNGPGWEHGFFGLTAENIGTFFAGGVPHTGRGLKPEVTAERLTRLVERLGRPPEQADWRPMAPLLQDHAAQDWRDVITRLTVPSLFLAGHDSQVWPWSHATAAASLNDRAEALILDDCGHAMNIDQADQVGTAIARFAGALR
>NC_021191.1|WP_015618250.1|190157_191558_-|FAD-binding-protein
MSRTHPLISDLPELDVVTDADVLASLSHDDAEWAPVGKPVAAVRPRTTEQVQAVVAACAAHGVPVVTRGAGTGLSGGANAVDGCLVLDLSKMNRIIEIDPDNMIAVVQPGVVNNDLKAAVAEHGLWYPPDPASAPWSTIGGNVATNAGGLCCLKYGVTRDYVLGLQAVVGGPAGSYGTAVRLGHRTTKGVAGYDLVGLMVGSEGTLGVVTEVTLRLRPARAESPRTVVGAFDTIVAAGDAVAATTRLGLLPTALELLDKACLQAVEEWKHLGLSATAEALLLAQIDTPGKAGDEEAAALAQVFRDAGAEWAEQSTDEFEAEALFSARRLAYPALERLGPVLTEDVCVPRSAVPEMLAAIEEIAARHQVAIATIAHAGDGNLHPLIRTPAGDSQAQAAAQAAFDEMLRAAIALGGTVTGEHGVGLLKRGGLRQEQEPAVLAMQEAVKQSLDPRNLFNPGKVLGDPAS
>NC_021191.1|WP_157408188.1|189259_190090_-|hypothetical-protein
MIVRVMRAGAVVTVLAVAGCSAVDDGGRDWNPDHQPGYVLPGDNNPAPTATWPGEGSGLGLPGLGQADPSEPDHVAHGGSGYVDAPATFQLVNPADVVRVKLADLNGDLYSVSTPAQSKSIPVASVDHNNVAAGLRDSGLGGPALVTVVLAKDVRWRVRLSGGASDETVDLSAGSAGGDVDLSAGVTRAEVFLPAAAGTQRVILSGGASQLVVHLAGTAPARVAAGNGAGTVTIDGQSQSGVAGGTVFAPPSWDTAPNRFDIAATAGVSDLTVAHS
>NC_021191.1|WP_041833060.1|182559_183408_+|Rieske-2Fe-2S-domain-containing-protein
MRQMISRLEKASALDALSDRIQGAVQSATPRRLRDVLHGTWVGHPLHPVLVQVPVGAFISASVLDALPGQSKAATTLIRVGVAGAVPAIAAGWVDWSSLSKDQRRVGLVHAAGNAVAVGLYVGSLAARSSGRWGLGRFLAYAGLSVAGGGAYLGGHLSYEQGAGVNMASADVLKLPEDWAEVGLVTSLPEGKPTVRTVGDVRVLLYRQGEDVTAMIEQCGHQGAPLGEGDVEGTGADACVVCPWHGSTFRLVDGVVRHGPAAGDQPTLRTRIRDGVLSVATP
>NC_021191.1|WP_015618260.1|203456_205712_+|hypothetical-protein
MAVTFIGVRHHSPACARVVAATIDELRPAYVLIEGPADLNGRIDELLLGHELPIAVFTSYRDDERRHGSWAPLCDYSPEWVALTHAREVGAELRFIDLPAWHPAFEGRSNRYADAELRYADVMDRLCRSFDVDNVDVLWDHLFEIGPVTPAQLDTYFDLVRGNAAAGDSDTAREAYMARWVRAAAAAAGDRPVVVVTGGFHRPALVSALAAGGDSGWPEVPVLPEGALGGSFLVPYSFRRLDAFDGYQSGMPSPAYYQELWEAGAEEAARHLVESVAGRLRDRKQPVSTADLIAARATADGLAMVRGHAHPARTDVLDGLASALVNEALDKPLPWSARGILQAGSHPVVVEMVAALSGTRVGRLHPDTPAPPLVHDLDAELTRAGLDGTAQLKLDLTRDADRSRSRILHRVRVLGVPGFERTSGPSTGLDPTLHEQWAVRPDPGRLTAVIEAGAYGATLLDACAAVLAERARDNQDIDVLAVVLFDAALAGVTSVSEQALTDINGTVATAADPGALGRMLAVVLTMWRHDRIFGTAHSAVLGEVITTAVRRILWLAEGVRGGAAPADLGRIAAMAACRDALRHAGQALGLDVPEALDVAARVAADAEAPPELRGAAFGLRWALATDPVLDPARVVRGAFGAASAGDWLAGLFGVAREEVLHTDEIVALLDDLVSAMGSEEFLIALPALRQAFEFFPPRERETIAEQLLARRGRRGGRALLRGGGTDPALVAAGLHLDERVDTLLRREGLLT
>NC_021191.1|WP_015618261.1|205708_206824_+|VWA-domain-containing-protein
MTAPDSDLERWRLVLGEPASAMGALSAAGAAQDAALNWLYGRDGEHDKRDVRNGGSGESTLATVDWLNEINRLFPRETIERLQRDAVERYEITDIVTDAAVLETIEPNPALLRAVLQTKHLMNPEVLRLARRIVEAVVRDLMAQMATEVRAAFTGTRARRPSRWKQARDFDMTRTLRANLGHYRPAERRLYIETPHFFSRTRKHVEQWQVILLVDQSGSMVDSVIHSAVTAACLWGLPGVRTHLVAFDTNVVDLTSDVDDPVELLMKVQLGGGTDIGGAVRYGAGLIEQPRRAIVAIISDFYEGGSSSLLIRTVRELVEQGTKVLGLAALDSQANPAYDRDMGQRLANVGAAMGAMTPGELAAFVAEQVAR
>NC_021191.1|WP_015618262.1|206876_208829_+|hypothetical-protein
MRADLLALTADTLAELTNRGLVKRAARELERGVPVLTVDDAGTVHAVFADGVTTALPVGGLDQGTCSCGAAGVCRHVVGLVLACLQQPAPAGDAAGAEEKPAADIPAGSWSPGEFTDDQVAARIGERAVAAARRVEAAGYVARVHRGHGADRVPSVELPTATVRFLVPHDLGFARTDAVAGARDDVLALAVWAFRVADERAPGEADVQVQVGGAAQAAGPGLDSAVALAGFVLREGAVHLGAGTTAQVAVVRRDLEAARMRWPLLAVEDVVAQLQSYGERSARYRPEALADHIAELVARHRAVTTGGAALRSRVLGTDEASETPLRRARLDGLGARVSTVGGETMVDLFLAHADSATVLVLHRAYETLDAGPQLAGRRVAGVTIGALAGGAVVTESAARSASRTVRLGTRRLSRTEAMASRGSWQDLPPALIAADLTALAAELDTLPPRPIRARVEAELVRVIPISEVRSINYSPGAQRVDAMIADAAGTTAVISAVHSSAAPGRLDAMAAALGGTVRYVAGSVRRTGGGIVIDPIGFAVDGGVVVPDLAPVTPSSFDGPAPVSRDPLDQALDDALSLLAEVAHRGLLHVPATMGVRLKETGGRLRAVGLRRAADELDVLAGLLGPDPGDAAIEAWVNAHLRVSLAVDLR
>NC_021191.1|WP_015618263.1|208825_210028_-|fibronectin-type-III-domain-containing-protein
MNRRLAAAATALLAGLIGGFFLPSGANAAGDAPITDIGIAAGTVVNGPVTLRPTVADGADVAAIKLEAVAGSFDDLSQGDYAAPWEITFDPLNFLDQNVTLTLIAVDSAGNGTRSEPVTVYVDRWGPSYTIDNPAEPGWGWYVSVHQPIRISASDRAGLDRVELVQKGKVVRSVSLGIKTSGKASLSLDPATKNGGATVTIRLFDRFGNVTSNDFWATVDNDKPTGVFRPSGTYLKGTIDAWPFDQNDNTYVRSMRSYLDDHKGGYATTQYPLDVWINTRVVKDGKHTLSFELTDLAGNTGAVRRTVYIDNTVPSVSLSSAPKNKAKLKKKVTLKAKASDKYGVAKVQLLVNGKVAATDTKAGYQFTLNPKKYGKKFTVQLRAYDKAGNVRYSAKRSYSR
>NC_021191.1|WP_063642940.1|210092_211187_-|hypothetical-protein
MKNARKSYFAVVTAAVAVAASAVVTLSGAQPASAAKVSANCTNTTSDAATIQSAINGSASGDEIVIDGPCLITQTITLLGNRGYRGDSAGTTLTESSGKNLAAVLASDSWVNNSATTGDPITLSSLTIDANKSGNPTGGDAVIIRSWNTVVSDLRIRNAQGNGLRVTNTSKNGTTLTNTQVNGTIRASFVTGSGGNGIYVQDSGNSVTDWNLTDNWIASSGGNGIRTENAAGWTIERNHVYGVGGTGIDADRLFATSIGDNYIEDFNTNGIGVTVQGDAASTISGNRIFHFSGSGTTYLAVRQVNYGAGQIAVVGNTIRGAGTGVGLSYQQGGNSLTVTSTGNLVTGVTTARSVGSGVTVTSGV
>NC_021191.1|WP_051167223.1|211280_212003_+|hypothetical-protein
MEVLLFPHILIRYEARRWELPIGREITIGRGSGCDIRLPQDDHLSRHAATVRVLEDCLLITNESRVKPFVLRAPVGEDRLVEPGAATGSKPWQRFALVFAGEGGSPVRVEIDATALPQPEPPGEDARARVTVSAPLVLTNAQRRVLAALCEPLLTRSGPAAAPATYSQIGARLGRQPQYIRNVVKSIREQLSGHGIPDLIADADGGPEDFRWTLSRWAVRSHWITPADLAELAVNAAHEG
>NC_021191.1|WP_084503982.1|211983_213477_+|hypothetical-protein
MRLMRAEDVTQGGPELPGPEEPLYAGPDEDPDRYELSGPGATGGEGVVWPARYAGGLSSPLPAALKMLRKSAREDGTWWRRSLDQAALLRHLRLEHLVHVHEVFVGAVPHPRGTAAAMDARAPFVAMEWLDGPTLQEELGGIPATAADLPRRLGFVADTAETLAALASATQSAGNPSLHRDIKPANGIVHPQRGLVLIDITTLRRFDDGFDSTGLHTPGYTAPEVLAAPNLPRSLASDMYSLGALAVFCLTGDDPHPGEKLRADLLAVAGSVQIANPRAFVDHVLAALADEPGERPADPVGWARRLQDLAAARPRRLRLAAALGALVLVLSGGGVALAHPWDDAPATTAAPVPTASSRPAVRGAAGTIRTPADRSQVKQCAYFSGTAQLGAGMTLILVMQNLSNNDDHRYAELVYDWDKPATLSEWQGAQYFGQINDAAGQHYVVDLVAVDFAAARRNVNAADFGDALARQGTVLDSIEVTRVPGAGPRNCDGPPPK
>NC_021191.1|WP_015618269.1|213500_214394_-|CHAP-domain-containing-protein
MKLLTVLARALLTGSVLTAVALAPATGALASTPGQLDSGATLGPGATLYSPSGNMALTMQTDGNLVLYAPGHVAVWATGTSSAGNGTILAEQSDGNLVVIAPGNHPVWASGTSGHPGAVLQVQDDGNTVQYGSGHAALWSTNTSTGTSSVASLAVANQGATACGRNSLGGTGFYTSCKPENWCADFAMWVWAHSGYNVSGLSPAAYSFYKYGKDRGTLHAHPAVGDAVVYDVSGTYASHVGIVTGISNGLIHTENGNWGGSSTTTSSVKPQDMPDSTTIGTRTSFGKTVSGFVSPVR
>NC_021191.1|WP_084503983.1|215347_215569_-|GNAT-family-N-acetyltransferase
MGREHWGRAIATRALNQFVHELPDRPLFAHVAAHNAGSIRVLQKCGFQRDHAQEARTPKPEDEIEEFIFVLPE
>NC_021191.1|WP_157408189.1|215523_216474_-|ISL3-family-transposase
MCDAIEQLLPHLAGVDIKEVQVGSALVLVAAVRGAEGFCPACSKTSSRVHSRYQRTLTDAPVAGRLVRILLRVRRFFCDNPECHSKTFVEQVNGLTRRWSRISDGLRRMLTAIGLALAGRAGARLATRLGMPTGRDRLLRLVRGLPDPPVGNVSVLGVDDFAIRRGHNYGTVLIDCETRKVVDVLIGRDAEPLTIWLQEHGSPAVICRDRATAYAEAARTAAPEAVQVADRFHLWQNLATAVEKCVARHKSCLAEPVDTSIAGSAEGEAAEPTGAMADRRRAHHALVHELLAQGAGGLLATGSGESTGGAPSRREH

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_2

315614-315694

Orphan

Consensus_repeat	Method
ACGCCGCGGTTGGTCTCCTCCAGCTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_2

>merge|NC_021191|2|315614-315694|CRISPRCasFinder
ACGCCGCGGTTGGTCTCCTCCAGCTCGTCGGAGAGCTGGTGGTAGAGCGCCATCACGCCGCGGTTGGTCTCCTCCAGCTCG

>NC_021191|2|2|315614-315694|CRISPRCasFinder
ACGCCGCGGTTGGTCTCCTCCAGCTCG	TCGGAGAGCTGGTGGTAGAGCGCCATC
ACGCCGCGGTTGGTCTCCTCCAGCTCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015618347.1\|302474_304508_-\|phospholipase-C,-phosphocholine-specific	unknown	unknown	gnl\|CDD\|274561
NC_021191.1\|WP_015618351.1\|308172_309339_+\|histidine-decarboxylase	unknown	unknown	gnl\|CDD\|235068
NC_021191.1\|WP_015618353.1\|313327_314881_-\|fused-response-regulator/phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_021191.1\|WP_015618357.1\|317664_318087_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912
NC_021191.1\|WP_041831786.1\|320424_321207_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227947
NC_021191.1\|WP_041833080.1\|305994_307425_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NC_021191.1\|WP_015618356.1\|316214_317252_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|340411
NC_021191.1\|WP_015618344.1\|300907_301777_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237874
NC_021191.1\|WP_015618348.1\|304662_305745_+\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|237171
NC_021191.1\|WP_041831787.1\|321256_321901_-\|CGNR-zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|378696
NC_021191.1\|WP_015618343.1\|300383_300911_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NC_021191.1\|WP_015618345.1\|301761_302229_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_021191.1\|WP_084503993.1\|309356_313250_-\|NACHT-domain-containing-protein	unknown	unknown	gnl\|CDD\|238121
NC_021191.1\|WP_015618350.1\|307435_308176_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618358.1\|318086_318926_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912
NC_021191.1\|WP_015618355.1\|317248_317668_-\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|340411
NC_021191.1\|WP_157408680.1\|322053_322890_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|366659
NC_021191.1\|WP_015618359.1\|319197_319551_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|273042
NC_021191.1\|WP_041831784.1\|319656_320115_+\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|376605
NC_021191.1\|WP_041831785.1\|320178_320412_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015618347.1\|302474_304508_-\|phospholipase-C,-phosphocholine-specific	gnl\|CDD\|274561	TIGR03396, PC_PLC, phospholipase C, phosphocholine-specific, Pseudomonas-type. Members of this protein family are bacterial, phosphatidylcholine-hydrolyzing phospholipase C enzymes, with a characteristic domain architecture as found in hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes of Pseudomonas aeruginosa. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, but unlike PlcN can also hydrolyze sphingomyelin to ceramide ((N-acylsphingosine)) and phosphocholine. Members of this family share the twin-arginine signal sequence for Sec-independent transport across the plasma membrane. PlcH is secreted as a heterodimer with a small chaperone, PlcR, encoded immediately downstream. [Cellular processes, Pathogenesis].	0
NC_021191.1\|WP_015618351.1\|308172_309339_+\|histidine-decarboxylase	gnl\|CDD\|235068	PRK02769, PRK02769, histidine decarboxylase; Provisional.	1.05609e-90
NC_021191.1\|WP_015618353.1\|313327_314881_-\|fused-response-regulator/phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.73213e-44
NC_021191.1\|WP_015618357.1\|317664_318087_-\|STAS-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	1.64777e-30
NC_021191.1\|WP_041831786.1\|320424_321207_-\|hypothetical-protein	gnl\|CDD\|227947	COG5660, COG5660, Predicted integral membrane protein [Function unknown].	3.06028e-21
NC_021191.1\|WP_041833080.1\|305994_307425_+\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	8.62647e-18
NC_021191.1\|WP_015618356.1\|316214_317252_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|340411	cd16934, HATPase_RsbT-like, Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains. This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.	2.47607e-27
NC_021191.1\|WP_015618344.1\|300907_301777_+\|hypothetical-protein	gnl\|CDD\|237874	PRK14971, PRK14971, DNA polymerase III subunit gamma/tau.	8.5075e-05
NC_021191.1\|WP_015618348.1\|304662_305745_+\|transcription-termination-factor-Rho	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0
NC_021191.1\|WP_041831787.1\|321256_321901_-\|CGNR-zinc-finger-domain-containing-protein	gnl\|CDD\|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	5.67581e-14
NC_021191.1\|WP_015618343.1\|300383_300911_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	9.81741e-43
NC_021191.1\|WP_015618345.1\|301761_302229_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	7.76439e-06
NC_021191.1\|WP_084503993.1\|309356_313250_-\|NACHT-domain-containing-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	4.54158e-17
NC_021191.1\|WP_015618358.1\|318086_318926_-\|STAS-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	5.95658e-43
NC_021191.1\|WP_015618355.1\|317248_317668_-\|serine/threonine-protein-kinase	gnl\|CDD\|340411	cd16934, HATPase_RsbT-like, Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains. This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.	2.41488e-38
NC_021191.1\|WP_157408680.1\|322053_322890_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	1.42424e-16
NC_021191.1\|WP_015618359.1\|319197_319551_+\|STAS-domain-containing-protein	gnl\|CDD\|273042	TIGR00377, Anti-sigma_F_factor_antagonist, anti-anti-sigma factor. This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions].	6.89646e-29
NC_021191.1\|WP_041831784.1\|319656_320115_+\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	7.50192e-53

>NC_021191.1|WP_015618353.1|313327_314881_-|fused-response-regulator/phosphatase
MTPATVLVVDDSATKRYLLVSWLSRAGFTVVEAETGGAALDVLRTGGTDIDLVVLDVKLPDMSGFEVCERIKTDPVHGVLPVIHVSAHAVDVVDRTQGLNRGADAYLVEPIEPDELIATSQAVLRYYRARQRAETLAARMLKLAETTLAINSAPTLAALLQAAADGAYGIFGGPTVVVAETAEGEGLAATAMDGPATVRPWTVEHQETAVGSTVRTEQPDAWALVTWPEHEQVAIAASRLRNDRTPVYVAVPASSQSPGFPVLRQLSQAVAAAVEAQRSFDEEHRIAVTLQRSLLQSRLPDVPGLELAVRYEPAGAQTEVGGDFYELTTLDGRLLVAIGDVAGHSLHAATVMAEVRHAVRAYAVEGHPPGAVLQLVNHFMRTVLPTESATLCLFTLDPQTGHIRLASAGHLPPLLHVAGSGATFLSPRGPLLGINAPRPDDLEFTLPPGGTLVLYTDGLIERRDTDIDVGLKALAECAADVDPSLDAFCQRLLVNLAGAEEQADDIAVVALRRSAGQ
>NC_021191.1|WP_084503993.1|309356_313250_-|NACHT-domain-containing-protein
MSARWSRTVSRAYVALLPGLLWWSLANAAVGAAVAVLIAATQLFLDYRTYVRDQDAAPRSVADTAADLAANVQSQWSKEAQARGLNKARMLPVSWSAPAEPGADATTLRRIRGSYEQTTAKLAGLYLGIDNRQLIVLGEPGAGKTALAILLTLGVLNRRAAESRLPVPVLLPLARWDPVTEELDDWIVRTVAVTYYGCQERVARTLLDGGRLVPILDGLDEIPERGRREAVEKLSAALSTDRPLVVTCRSAEYRDLTEETTSPLSALLVEVAALPPEDVVDHLRRQGWTTGAGWEPVYERITATARSPLRAALSTPLMVSALCTVGRRNRVTPEDLLKRAGSRAAVEKYLLDGIIDAVYPDPAEAAQARRWLGFLARSLHDHRDREFAWWQLSSRMASVWLAPVVGICTGLLFMAATTAWIIAFDTTGAVDNATTVTASVGVGAAVAVLSTIVWFAAPGRPPLRLAPPRPHAAARLRIGFAVGAGWTGILAVPLPVITAVVLVVSDGWTLHTADVCARVVMVVISLAAVVGLACAVTHWLEAEPARAAHPDPLRSIQDDRRSALAAAWAGGLTFGALVAPVLAAGLTAGRMLSRLSTGGAGWPGGVPVGSTLLASVHDVRYRWFPTTGLAVGALFVLPTTTMFLVVLLTRAWPRFHLVRLLLAARQQLPRSLMDFLAGARNRELLRESGAAYQFRHARLQERLAVTGRPSVSTPEPGTARVSRTLRRTFVATTTAAVLVIVVAVLRLPADRSDHTLAGAYRKGPYDAVFSPHGTYVAMLSGADPDVRIYAAATGERVSVVPGNIVSYTGTRVMFSPNDRFAVVSSGGSPNPYTSPAARTTVWDLTQKRALLTVPYAAEDFYPDSTEDPMFAFTGNSDALIVSAPPDELHRFGSVIAWRLPAMETIGEWTKPYSSSDYELNVPAGVIAVRVARDRVTVWDLASGTELGRLPDQETSLEPDVLPGSGRAFVVPRTRPGGVNRWVDLVDRMTLRVTASFPITSAVSASAGDLAAFAGPGGVIRVVDVASGTIRATAHLHGLAPGSSIDDSPEISPDGFLVVARGWAYPTTVRDSDGVHLTDEDYRVAAYGTANHRALLLTGKTEQDDQQYELFDTGTGKMLAVFPEELVDSTAGTTFSADGRLLLVPMGNHLVRVYDATTGTIIGDLPEPIEYRQFSRYSAGPPASADGRTVLTRQSRPDSRSGIRVAIRDVATGRVLARATAIDEYETRTIAFSPDNTLVATVGTDGVVHVFNKADGGVVATFAGHSGVGYALTFSPDNTMIASGAHDDTVRLWRIPGR
>NC_021191.1|WP_015618351.1|308172_309339_+|histidine-decarboxylase
MSRLDEAASLISGHPVDVDAVLAATLAQRDAEAGRHMFFPTGPTGDFRALRPLQDVLWNNIGSAASNPPGGNHTKSLERALLAWAADLFDLPADDWWGNATTGGTAGNRAGLLTARDRFPRTPHGVTTAVAYYSAAAHYSVPKMLHELNIPAVRVGVDTYGEMDYDHLASVLRPEAPAIVVVTAGTTMTEAVDDPRRVTAVLDASGIVDRYLHCDGALSAIPLALDKELTTEGVDSISLSGYKFLGTPRVCGLVVGRNATRRRTQHISYIAAIDDTPVGSIDGLPIAMMWYAVATAGNEGLRNQAHAARRLAAYASSSLNAIGWPAWRHPWAFTVVFPTPPLSIQQTWPLATDATGQSHLVCMPRTSKDQVDAFVEAMAREVWHRLSA
>NC_021191.1|WP_015618350.1|307435_308176_+|hypothetical-protein
MTQQQYPGRHHLNPSQQQQPQPLHPVAEPQGLPASVRGRALDRAMQVNASHARNAADRIGTRDALGEHALVLFSVDETARPFRLSVATRLDYEEHRGENLPALLQALGQHAWNQIQAAYRTGKRWDPRTPMDGLVLRSDPVTPETEYIGLAISTLDTPTAPWHDLKRSVSSADGLNLSGQGYLYLRDGTAMYFLRAAQTGSGAGQHTIVTNRAVHSIYRPRMDNELPGDPQVWQGLEKLHHVLMSA
>NC_021191.1|WP_041833080.1|305994_307425_+|APC-family-permease
MASLDRKTMTAPAMWVFAVAASALPVVLLGSIPATYATTGVLALPLVFLLVGAVVGFLSVGYTEMSRQAPHPAVYYAAVGRGLGKSAGVAAGIVALVAYNGIQTSLYGLLGAQLSDTFGGKWWVGALVVAVLIAMFGASGITRSTAVLAVVLAVSVLVVFLFVIAAVQHPADGYNPDGFSTSGLTGGVGGAAAYVLASLMGFEAGASFSEEARTPRGPGRSVKVALAVLVVVYSVTAWAVGVAVGPGQVTAALPDPMTAFDDQYGPLMPPFVTMVLIFAIVTSMLALHSIAARYGFAMAREGVLPKWVRSTGRDARVGAPVGGSLLQSGIAVAVIVVFAVLDLDPLASLFAWFSTVGALGLLSLLIVTSLSAMRYLRAGGPAPATAWKRVFAPGLGVLGGAVVLVLMVVNVDALLGSAPGSSAPLIIPAVVVAFALGGLLWAAYLRSSRPETWQQIGQGAGNRHAVPAARLADIEL
>NC_021191.1|WP_015618348.1|304662_305745_+|transcription-termination-factor-Rho
MTDISHLLDIVDDRAWLRADGYLPGPDDIPVSLAQVRQLGLRRGDLVTGTAELNGRKPAGLHVDKPGRRPDFYQLTALYPQERLRLETTPDVLTTRVIDLVMPIGKGQRALIVAPPMAGKTTVLKQVANAITTNNPEAHLMVLLIDERPEEVTDMRRSTRGEVIAATFDRTPHDHTALAELAIERAKRLVELGRDVVVLLDSITRLGRAYNLCAPGRGRTLSGGLDVSALHPPKRFLGAARNIEHGGSLTIIATALVETGSALDTVIFEEFKSTGNAELKLDRQLAEARLFPAVDLAASGTRRDETILAPGELAAAAQIRRALTGQDRRESLHHLLAQLRTTGSNREFLQRVARSLAIAG
>NC_021191.1|WP_015618347.1|302474_304508_-|phospholipase-C,-phosphocholine-specific
MATVDRRSFLRMAGLPAAAAAIPLDLSKALAIPAHQRTGSIADVEHVIILMQENRSFDHYFGTLRGVRGFADPHPMRTPDGKTVWQQPQANGPDLLPFRPDVPDLGRTFLPDPPHGWNDGHAAWNNGWHNRFVPNKGVTTMTYHNRSDLPYQYALADAFTVCDNYRCSLLGPTDPNRYHMWTGWVGNDGQGGGPVITNAEAGYDWTTYPERLERAGVPWKIYQDVGTGLTAAGSWGWTQDPYIGNYGDNSLLYFHQYQNAAPGTPLADRAKTGTDVSALGRNPEALLSDFRRDVESGRLPAVSWIVAPEAYTEHPNWEPAFGAWYVSQVIDILAAHPEVWSKMALFVTYDEEGGFFDHIAPPTPDVSTVPTTNEIYPGSAGNPAGPYGLGLRVPMIVVSPWTRGGWVNSQLFDHTSLIRFLEARFAVGEPNITPWRRAVTGDLTSAFDFKTPNRTRPVTLPGTDDFKPGDLVRHPDTVPVPPADQKLPRQEKGVRPARPLPYTLHADGKVAGGTLTVTFRNTGRATAVFHARSSENPRSYTVEPGKTLTGTWPAVDGYDVTVHGPNGFYREFRSGPRAAAGLSLRTDYDLRAEKVTLTLTNGGSSRLQLTVHDAYTSARTTISLRGGQSEQKSWPVVRTRGWYDLEITAGAETTYRAAGHLENGKDSITDPRMGGLL
>NC_021191.1|WP_015618345.1|301761_302229_+|hypothetical-protein
MRRPLITLLAASALAGCSATQAPAAAPNPQTSSAPVVSPAPASPVPKAAAGPVPGATASPAAKTVVKNKKSPCPVTAKQLKAASPHAPAPFEKIECHEDIAMAVVPQSKDPNGYDAAVYVFTHDAGGWREIAQGSSLNCYDYMPGNMAAHFSYCN
>NC_021191.1|WP_015618344.1|300907_301777_+|hypothetical-protein
MTDDHRLLRQTLSDLAEHGGHADLYERSLRTSKRLTRNRRIVTVVAALAVVAGIGTPIAVANARRAAPPPQILVPPSVGPTVTSSPAPSPSHAPVPSGTGTPAAHSATHPAPPITTPPSSPPSSAVSHAGCPVSAKVLSAVAKSKVGEVECHGRYAIGVGANAGMVFRYDRSADTWHLVGEGSAEICQAYLPRSAWGDFELCGSADPAVACPMAQTDMQNAVAGSEFADLRDGKYFDARSCSGTRATASVGAPDPTAYFIFTWRQSSRTWKATDAGPCPSEGIEECDAP
>NC_021191.1|WP_015618343.1|300383_300911_+|SigE-family-RNA-polymerase-sigma-factor
MGDRGAEAFGEFVRARTPALLRTAFLLTGDRHLAEDLVQDALARTHRAARRLRDDGHFEAYARTAMYHLQVSRWRRRRVAEAMSATPLDRAAPGSDHAGRVDLQVSLHAALALLTKRQRAVLVLRFFEDRTEAEAAELLACSVGTVKSQTSKALARLRQIAPELLETQISKGAAR
>NC_021191.1|WP_015618356.1|316214_317252_-|SpoIIE-family-protein-phosphatase
MSGGGEATQHLPEGLLDDGVWYQVEAASTAAAVRRTAERLATELGVPDKDTADLAIVVAEAAGNLVKHATGGALLVRPVRARQRAGVEIIAIDKGPGMADVLQAVDDGHSTTGTLGIGLGAIVRQASWSDLHSVPGRGTVLAAQVWPGGEPETGWAAGLTRPLTGEPVSGDSYAFREADGRKQALMCDGLGHGRLAHAAGREAVRVFHSAPAMPPAAVVELLHRTLSHTRGAALAVADLDQQGSVLRYAGLGNISGIILSPEGTRRGLVSLPGIAGHQKRQIREYEYPFAAGCVLLMHSDGVVDRWNPYDYPGLLTHSPQVIAATVLRDAGIRRDDAGVVVAKLP
>NC_021191.1|WP_015618355.1|317248_317668_-|serine/threonine-protein-kinase
MTTWDGVAAAERVEVTSDQDVVRVRQLVRSVAVAVKLSLVDQTKVVTAASELARNTLVYGGGGSVEVFRVENGRRTGIKIIFADQGPGIADLDLALTDGYTTGGGLGLGLSGARRLVDEFDIDTEVGRGTVITITKWSR
>NC_021191.1|WP_015618357.1|317664_318087_-|STAS-domain-containing-protein
MERVPVLKIGDTLLVSIQIDMEDQVALQLQEDLAEKIVATGCHGVIIDISALDIVDSFVGRTLATIASVSKVLDADTVVVGMRPAVAITLVELGLSLPGIRTALNVELGMELLARARVDDDPESDEEQAGTDPESAVSHP
>NC_021191.1|WP_015618358.1|318086_318926_-|STAS-domain-containing-protein
MALSSHEASSLADLFKAHEEAITTAWTDAVARSLRGRLSHAELQRQVSDLQRGFQAALAAGAQDLTDEAADELRAQLSELSGTRARLGFSANETAVSVFALKEAVFQVVNADDAAALRTYVGFSSFVDRAGLFTFDSYVRVREELIADQAEQLLELSTPVVKLWEGVVAVPLVGTLDSARAQVVMERLLQTLVDTGSPYAIIDITGVPAVDTQVAQHILKTVVAARLMGADCIISGIRPQIAQTIVALGIEFGDIATKSSLADALRYVLKLTGTTKRER
>NC_021191.1|WP_015618359.1|319197_319551_+|STAS-domain-containing-protein
MSLTVQTEQRGDVVVVSVGGELDMATAPQLQDQISDLLEKGRTRLVFDLAEVSFCDSTGLSVFVRAKNSTDDAGGVVRLAAPQRGVLRILEVSGLVEVLHTYPTVDEAVTAEEPALD
>NC_021191.1|WP_041831784.1|319656_320115_+|large-conductance-mechanosensitive-channel-protein-MscL
MLKGFKDFIMRGNVVDLAVGVVIGAAFTAVVTSFTNAFLKPLIQLMGGNTKVGAGTWKVGDGVVFDYASFINALITFLLTAAVLYFLVVFPLNKLAERRKRGEEPPPESPSEEVKLLTEIRDALVRQQVAPGAVNDLLGRQQNQQGYQDRGY
>NC_021191.1|WP_041831785.1|320178_320412_+|hypothetical-protein
MEQRKHWWNGRWGRVARKDVFLRTSGDQWYVEQRAGGSDGVSHFFEYDSEDAALDMVRALLTGQDEWRELSVRPRPR
>NC_021191.1|WP_041831786.1|320424_321207_-|hypothetical-protein
MACEQWRELLSAQLDGEDDPADRARVDEHLTGCAGCREWLDRAATVNRLTRTGLVTDVPDLSGAIMAALTGPVEAGTGAQPGVDRRSRATAILYVALAAVGAVQLILGLTQIGGGASSLHVHTGVDATPGHLWHESAAWNVAVGAGYLFIALRRTRPNGLVPMLTAFVGMLLLLSVNDLSAARVDGERLVSHGFVIMGYLLVVALSRVTGAFAQPPGSRMSPGAGWHLVEEEPEAPSRPRLRLVPRGPLTARHDEHREAA
>NC_021191.1|WP_041831787.1|321256_321901_-|CGNR-zinc-finger-domain-containing-protein
MSWMASARHGVREAPAGLALVQDLINTRGTMSYAPDLLANPDDAQRWLTEALATWSRVAALPAPVILLSSTDMRSLRRLRTTFEGVILAGSGREPGNDGALPPADVPVTLVPEADGWVRIVPAGRGTRWLASALWAEALLAQQAGIWPRLKLCNNVECRAAFFDTSRNNSGVWHDVSTCGNTANLRAFRERRRLLGNTGGQGGLTPPGPHPDLA
>NC_021191.1|WP_157408680.1|322053_322890_+|L,D-transpeptidase-family-protein
MRKALTFAVAVTAAATLATACDSGGTDQASAPPGPAPAISTTPSTAPGQSTAPAQGGPSASASTPAPSEPATEPPAKPVEPEKLRSGAKGDRVVALQQRLTELGYWNGKADGTFGGQTQQAVFALQKAAGLTRDGVVGPKTEKALAGGVRPKARSTSGYVIEINKKRQLLMLVQDGNVKQTFNTSTGSYERYEQDGASHIAATPSGKFTVSRQIDGWRNAPLGMLWRPKYFNGGIAVHGATSVPPYAASHGCARLSLSAMNYLWTSDKIPLKTKVWVY

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_3

499331-499409

Unclear

Consensus_repeat	Method
CCCCGCTGAGGCGGGACGGCGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_3

>merge|NC_021191|3|499331-499409|CRISPRCasFinder
CCCCGCTGAGGCGGGACGGCGTCAGGCGGCAGCCTCGGGCCTTCCCGCTCCGCGATCCCCGCTCAGGCGGGACGGCGTC

>NC_021191|3|3|499331-499409|CRISPRCasFinder
CCCCGCTGAGGCGGGACGGCGTC	AGGCGGCAGCCTCGGGCCTTCCCGCTCCGCGAT
CCCCGCTCAGGCGGGACGGCGTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015618547.1\|501361_502198_+\|PSP1-domain-containing-protein	unknown	unknown	gnl\|CDD\|224688
NC_021191.1\|WP_015618549.1\|503338_503809_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226769
NC_021191.1\|WP_041831813.1\|486490_487021_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618550.1\|503889_504540_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|375435
NC_021191.1\|WP_041831816.1\|505151_505943_+\|zf-HC2-domain-containing-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618555.1\|508097_508718_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618538.1\|490824_492117_-\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|130740
NC_021191.1\|WP_015618534.1\|484047_486417_+\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|234827
NC_021191.1\|WP_015618553.1\|505951_506749_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213231
NC_021191.1\|WP_015618540.1\|492891_494097_-\|amino-acid-deaminase/aldolase	unknown	unknown	gnl\|CDD\|143488
NC_021191.1\|WP_015618537.1\|487969_490795_+\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|236048
NC_021191.1\|WP_041831815.1\|502221_503346_+\|geranylgeranyl-reductase-family-protein	unknown	unknown	gnl\|CDD\|273936
NC_021191.1\|WP_015618543.1\|498099_498426_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618544.1\|498425_498734_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_063643120.1\|487023_487803_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618554.1\|506748_508101_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618542.1\|496787_497978_+\|DNA-polymerase-III-subunit-delta'	unknown	unknown	gnl\|CDD\|236134
NC_021191.1\|WP_015618539.1\|492260_492890_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380058
NC_021191.1\|WP_157408208.1\|499468_501121_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618551.1\|504612_505155_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236608

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015618547.1\|501361_502198_+\|PSP1-domain-containing-protein	gnl\|CDD\|224688	COG1774, COG1774, Uncharacterized homolog of PSP1 [Function unknown].	2.48061e-57
NC_021191.1\|WP_015618542.1\|496787_497978_+\|DNA-polymerase-III-subunit-delta'	gnl\|CDD\|236134	PRK07940, PRK07940, DNA polymerase III subunit delta'; Validated.	0
NC_021191.1\|WP_015618550.1\|503889_504540_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|375435	pfam17929, TetR_C_34, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in putative TetR family transcriptional regulators found in bacteria.	8.33697e-26
NC_021191.1\|WP_015618538.1\|490824_492117_-\|FAD-binding-protein	gnl\|CDD\|130740	TIGR01679, bact_FAD_ox, FAD-linked oxidoreductase. This model represents a family of bacterial oxidoreductases with covalently linked FAD, closely related to two different eukaryotic oxidases, L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae.	7.73044e-117
NC_021191.1\|WP_015618534.1\|484047_486417_+\|sodium-translocating-pyrophosphatase	gnl\|CDD\|234827	PRK00733, hppA, membrane-bound proton-translocating pyrophosphatase; Validated.	0
NC_021191.1\|WP_015618553.1\|505951_506749_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213231	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	1.10972e-96
NC_021191.1\|WP_015618540.1\|492891_494097_-\|amino-acid-deaminase/aldolase	gnl\|CDD\|143488	cd06813, PLPDE_III_DSD_D-TA_like_2, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2. This subfamily is composed of uncharacterized bacterial proteins with similarity to eukaryotic D-serine dehydratases (DSD) and D-threonine aldolases (D-TA). DSD catalyzes the dehydration of D-serine to aminoacrylate, which is rapidly hydrolyzed to pyruvate and ammonia. D-TA reversibly catalyzes the aldol cleavage of D-threonine into glycine and acetaldehyde, and the synthesis of D-threonine from glycine and acetaldehyde. DSD and D-TA are fold type III PLP-dependent enzymes, similar to bacterial alanine racemase (AR), which contains an N-terminal PLP-binding TIM barrel domain and a C-terminal beta-sandwich domain. AR exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Based on their similarity to AR, it is possible members of this family also form dimers in solution.	0
NC_021191.1\|WP_015618537.1\|487969_490795_+\|type-I-DNA-topoisomerase	gnl\|CDD\|236048	PRK07561, PRK07561, DNA topoisomerase I subunit omega; Validated.	0
NC_021191.1\|WP_041831815.1\|502221_503346_+\|geranylgeranyl-reductase-family-protein	gnl\|CDD\|273936	TIGR02032, Uncharacterized_protein_MJ1520, geranylgeranyl reductase family. This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll].	6.80124e-56
NC_021191.1\|WP_015618549.1\|503338_503809_-\|hypothetical-protein	gnl\|CDD\|226769	COG4319, COG4319, Ketosteroid isomerase homolog [Function unknown].	1.47023e-06
NC_021191.1\|WP_015618539.1\|492260_492890_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380058	pfam17928, TetR_C_22, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor present in sco1712 proteins from Streptomyces coelicolo which act as a regulator of antibiotic production.	7.89724e-26
NC_021191.1\|WP_015618551.1\|504612_505155_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|236608	PRK09652, PRK09652, RNA polymerase sigma factor RpoE; Provisional.	2.96591e-28

>NC_021191.1|WP_015618544.1|498425_498734_+|hypothetical-protein
MAGIADRLESAADEVTTVERGLAVHGASPGTFAADRYGGVPGRVGAQLHELWTTTLDSRSRDARDLSRRLAGLAADVRTTTRAYEETDDEAARRINRYAREA
>NC_021191.1|WP_015618543.1|498099_498426_+|hypothetical-protein
MPREIDEAWIDEAIERHRRLDALRAEFEQAVKAHVVTVHSPDDSVEVLVTAAGDITDVHIRGSLQQRNAADLAREVQAVVTNATQAARWAREKLHGEIFGAFRSLGEL
>NC_021191.1|WP_015618542.1|496787_497978_+|DNA-polymerase-III-subunit-delta'
MSVFADLVGQDEAVETLSRAAAAAARIVAGDTASVGAMTHAWIFTGPPGSGRSVAARAFAAALQCERNGTGCGECHGCHTALGGTHADIRFVTPEGLSIGVNEMRALVLRASSAPTGGRWQAVVIEDADRLTEAAGNALLKAIEEPPPRTVFLLCTPSTHPDDISVTIRSRCRVVPLRQPPAEAVAEVLVRRDGIAPDTAAWAAAAAQGHVGRAKRLAGDADARARREAVLAVPRRLTGVGACFDAASALIEAAEAEAGAASAESDGAERAALEQALGAGGTGRGAAGAMRGAAGQIKDLEKRQKSRLTRAQRDALDRALVDLAGFYRDVLITTMRAPVGVVHTDTAPQSAAAAEKWPAESTLRRLEAVLACRDAIEQNVKPKIAVEAMMLSLWRG
>NC_021191.1|WP_015618540.1|492891_494097_-|amino-acid-deaminase/aldolase
MIADRSALQKRLERATAHLETPLAVVDLAAFDANAAALARRSAGKPIRVASKSVRVRALLERVLHRPEWSGVMTYTLPEAIWLARSGLSDDILVGYPTVDRSAIAELTADPQLASVITLMVDSPEHLDLLDSVTDPRQRPDVRICLELDASWRPAGPVHIGVRRSPVHSAAQAGALARRLVARPGFRLVGMMAYEAHIAGVGDRPPGQAFRARAIRMMQRRSLPELLQRRAAAVRAVREHADLEFVNGGGTGSVAATAADPAVTEVAAGSGLLGPTLFDAYRAWQPTPAAFFGLSVVRRPGPRIATVLGGGWIASGPTGPSRQPSPWLPAGLRYRGDEGAGEVQTPLIGAAADELRPGDRVWFRHAKAGELCEHVNEVHLVDGDTATPAPTYRGEGHAFLG
>NC_021191.1|WP_015618539.1|492260_492890_+|TetR/AcrR-family-transcriptional-regulator
MSTPTVTTGPLRRVPVQGRSVARVQRMLDACAELVDEVGYEGLTTTLLAERAEVAIGSVYQFFPDKRAIVQALAMRNMDAYLQSLSARFANETFAHWWDGVDAAIDAYIHMHRSVPGFRTLHFGDVVDLHLLDAERDNNAVIADRLAELLVEQFQLPDRTRLRFALLIAVESADALIKLAFRRDVTGDDAVLVEAKALIREYLHRHVSA
>NC_021191.1|WP_015618538.1|490824_492117_-|FAD-binding-protein
MTTDLHWRNWGRNQRAIATDVLTPSSAEEVAAEVKNTAAAGRRVKAIGSGHSFTAIAVADDQRMLLTRLDRLVSVRGDLVTVEAGMPLHRLNDILAEHGLAMPSLGDIDQQTVAGAISTGTHGCGATHATLASCVEAVTLVTGNGELLTIDAGSPLFPAARLGLGALGILVQVTLRCVPAFVLLADERPMPLAQVLHDLDEQIAANDHLEFYWYPYTDRAQLKRNNKVPTSDRPLPAFRGWLDEQFLSNTVFQGACTLGRTLPAMVPAISAVAARALTARTYTARSDRVFCTSRRVRFVEMEYEIPREHLPQVLAELPRIIDRLPFKVQFPVEVRFTGPDDVWLSHGYGRDSAYVAVHQYSGAPYEPYFRAFEAICEPLGGRPHWGKLHYRNAESLRRAYPKFDDFLAVRDQLDPARVFSNPYLTQVLGD
>NC_021191.1|WP_015618537.1|487969_490795_+|type-I-DNA-topoisomerase
MPSNARTTRLVIVESPSKAKTIAGYLGPDYFVEASFGHVRDLPKNAADVPAKYKGESWARLGVDVDNGFHALYVVSSDRKAQIAKLQKLAKEVDEIFLATDEDREGEAIAWHLVETIKPKVPVKRMVFHEITRPAIQAAVANPREIDRDLVDAQEARRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRIVVERERQRMAFRSAEYWDINALLAVQGKVEGPRNFSATLIALDGDRIATGKDFEPTTGKVRANAGVVHLDGDGARGLAARLEDRPFAVTRVEEKPYRRKPYAPFITSTLQQEAARKLRFSASQTMRTAQRLYENGYITYMRTDSVNLSETALTAARRQIAELYGERNVPTQPRRYTGKVKNAQEAHEAIRPAGDNFRTPGEVANELSTDEFKLYELIWRRTIASQMTDAVGNSVSVRIRATSTAGEEADFAATGKTITDPGFLRAYVESSDDENAEAEDAERRLPTLVKDQPLTAEQLAAVGHHTSPPARYTEASLVKALEELGIGRPSTYESIMRTIQDRGYVEKRGQALIPSFLAFAVTGLLEGHYPRLVDYNFTAAMEGQLDDIAGGDHAALDFLTSFYFGSATAGADDAIAKAGGLKKMVTENLSAIDARSVNSIPLHTDEQGRNVVVRVGRYGPYLQRQLPDATEEAPEDRVSIPEGIAPDELTPEKVDELFLGGGGERILGQDPANGDQVQVKSGRYGPYVQAGERTSSLFRNQAPDTLTLDEALKLLTLPRILGADPEGAEISAANGRYGPYVKRGTDYRSLDSEEKLFTVTLDEALALLAAPKARQRRAAAPPLREMGEDPATKLPLVIKDGRFGPYVTDGEYNASLRRGQTPEELTIAQASEMLAEKRAKGPAPKKKVAKKAAAKKTAEPAAKKAATKKTTTAKKAPAKKTAAKATTAAPAAKKAAPKKAAPAKATASAD
>NC_021191.1|WP_063643120.1|487023_487803_+|hypothetical-protein
MGELAEPGWPLIPREVLPAPVEPVHPRPRRTVTHTAPAGKQLSVFGVEAVDPSLADLMGLLSGPGRLGRMGGTARVSVRVDAAWRVHVLVQELVSRGLVVNWQPVLENPPEERVAELTAVPVDEEADEEPPPPPETTATEAERTVAFEVRTAYSSRLNPLSRAWPPTAGKLFLNGPRLRLWVAAAGAPSRHGFILGLDPDASLDKAVDAALTKVGLAGTVQPGRTYEIAGRRRLARLAELVGERPGAAPERLWPGGAAA
>NC_021191.1|WP_041831813.1|486490_487021_+|hypothetical-protein
MRTARTIPLLLVCSLVVTLGACSSGPAPRVWAASVCQALAPWRSEIGTLTTRTQQQMNVATTPAQAKENLMRLFGGAQDASEKARKGVVDAGVPDVDEGKKVAESFTASLSAMRDAYGRARSGIEALAVSPAKDFYAKVTTVVQTLNTEYQASELDTTNLSSVELKEAFEEAPECR
>NC_021191.1|WP_015618534.1|484047_486417_+|sodium-translocating-pyrophosphatase
MSGSSTYLAADSGGVSLSGSNVTYVIVAIVFALIALAFAAVFVQSVLKAGRGTTTMQEIAGAVQEGATAYLFRQFKTLAIFVVVAVVLLFLLPVHGATDNETWVKIGRSLFFIVGAVFSSFIGGAGMALATRANLRVAAAAGEATGAREKAMGIAFRTGGVVGFLTVGLGLFGGALVVWIFRRDAPTVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVAALILGQAAFGQDGLIFPLIVSTIGVVIAIVGVFITRLRASDRNGLTAINRAFYISAVLSAVIVAVVSFLYLPDTFAGFKDSTLDAGVVASGRNPQLVAIGAVVIGIVLAAAIQALTGYFTEVERRPVQDIGKSSQTGAATVVLAGISVGLESAVYSALLIGAGVYGAFLLGGSSITLSLFAVALAGTGLLTTVGVIVAMDTFGPISDNAQGIAEMSGEVDERGAQILTELDAVGNTTKAITKGIAIATAVLAATALFGSYTNTLQSSLADAGISPDRIGTEVLNLLNISNPRNLVGLLVGAAVVFLFSGLAINAVSRSAGAVVMEVRRQFREFPGIMDGTQRPEYGRVVDICTRDAQRELLTPGLLAIMAPIAVGFGLGAGALASYLAGAIGAGTLMAVFLANSGGSWDNAKKLVEDGAYGGKGSDAHAATVIGDTVGDPFKDTAGPAINPLLKVMNLVSLLIAPAVVAWSVGTDENTALRVTIAVVAALIIVAAVVWSKRKPISMGDAEPSTTTPSERVSA
>NC_021191.1|WP_157408208.1|499468_501121_-|hypothetical-protein
MAFSRGRHRAERSLAAVARPALHSRPIIPVTDRGLPISGPEFGRENRRMSRWGTRRRRGLVTVGTLGAVGMLAVPLPVSAAPASCDQAERYAAQSGSQILRINSLGSAQAPPLHVGDARSALVAPGTVNSAAVARMLDVKESDTAAALTTPLQQQAPPTNAKPARRSTPSAEVGPVSLGDGKLSTQAQWQPGMACGATVGEVTQATARLREAGVLADGEAPLVHVPKVESGSSTELERDGDAATSVASAGLTGGGLELLGGAVKVRMLKPPSLRASMSTADGGEVRYIPAVVEVSGAGVETSRLDTAGDSVEITLAGKPSSQAADGASAPSPTLSPTPSATSEAATDETATGETAAGEAAAGAKRLPATGADTDHPSAPSVDGGGSTAKARLLGDLPAVGNLLGAGDNPPLPDVPDLPTVEEPATESAPTAGSDTVVHIELGDVRQASEGHAVAARAAALSVQITEGNDGTRTKPGYGGGRVLDFDMGVLEAAAVAPETAGAPRGGVSGGSGGGLPITGPTAGALTLTGLALVLAGAIAVAITRRSRPRT
>NC_021191.1|WP_015618547.1|501361_502198_+|PSP1-domain-containing-protein
MGMLCAVSFNRYGRLYYLDPGEFSPRVGDRVLVPTDDGPEVAECVWAAQWVSEDTDGFPKLAGLADERDLRRDEVLRKRKAEAKVAAKKLIKAHDLPMKVVAVDHVLEQGGTGGARTTIYFTAPHRVDFRSLVRDLGATLHCRVELRQLSARDSARVQGGIGSCGRDLCCATFLTDFEPVTIRMAKDQDLPLNPLRISGACGRLMCCLKYEHPLYTRFAETAPAVGTRVTTAEGSGRVVGHSVPKDAVVVRMDADGSRCSCSRASVCGPRQAHDEHYN
>NC_021191.1|WP_041831815.1|502221_503346_+|geranylgeranyl-reductase-family-protein
MAEWDVAVVGAGPAGLAAAHAAAAGGARTVVLERAEHPRYKTCGGGLIGTSLGLARSRIEVPARDTINALTFTNRGKFRFTRRSADPILTLVRRDDFDFAWYGAAVAAGATVRQNAQVRSIHQDDDSATVTLADGGTITAGTVIGADGSAAISSRHVGVTFAQQDLGLEVELAAAPADRVAWRGRVLLDWGAEPGSYGWVFPKDDELTVGVIMRKGRGAETKHYLTRFLEQVGLSGRRVVRDSGHLTRCRAADAPLRRGRVLVVGDAAGLLEPWTREGISYALRSGLWAGEVAAQAKTVDDLRAYEEKVLAELVPEMTAGHAMLGVFERRRALLHAAFATPLGWRAFEGFCRGELSVADVLERSHIAAAVRLLS
>NC_021191.1|WP_015618549.1|503338_503809_-|hypothetical-protein
MTVTRTDLDRIIDEFVAAFNESEPGLDRVMSFFAEDARYLPGHEPERRGIAAIRAEFAPQFAGRHGAMTFDVYDKVIDDERRRATIRWACRLDLTGAHGRRAMPALRWFARLRYRGRMQWHGLDVFHFDTEGRITGKFTYATFRLPLMAPDRSGVS
>NC_021191.1|WP_015618550.1|503889_504540_+|TetR/AcrR-family-transcriptional-regulator
MEASFQRARRPEQKGQRRDTILAAATELAQRSGVARVSLGDIATAVGLAKSNVLRYFGTREEIYLQIAMSEGTEWAGAVIAALPQADGIPGVAAALADAFVDRPLYCDLTTHAETMLEHNVSVAALQVYKEWAIEMYLRVGRHIAATAPELTDLDGAALVMAAGAFVTKLFPLTRPSAALRELYDREPQIARAFPPFRPTLRRMITATAAGMPAAH
>NC_021191.1|WP_015618551.1|504612_505155_+|RNA-polymerase-sigma-factor
MKPTVVTEEQLLRRIARGDRDAFDELYRRASPYLAMRLRRRCSDEGLVAEVLQDTFLSVWRTAGSFGPVRGAGGAGWLWTIAARRLVDALRAQQRVREVPTDELPVRSSPPAEDEALAGAVGDELGAALAALAPDLHEVLRAMVLDGLTVRETAVLLGLPEGTVKTRARRAKIALRGSLA
>NC_021191.1|WP_041831816.1|505151_505943_+|zf-HC2-domain-containing-protein
MTSHVPMASLAAYARGALDEASSWTVEAHVDSCSVCMMRLGDLAGPDVEAMVDAGRAGIEVHWPTAAPVRRSAWHRTLRHWTSWSLLAPAVVSVLAVLAAFVLDHEYPDRPSLVLLLAPVAPLTGLALAWSHHGDPGWEAVAGTARAGLDLLLRRSLVVLAGVVPPLAVVGWAFGRAPALWLVPCLTFTSATLLLGSLIGVARAAAVLGGAWVLGVATPAIVADVSPVLIEPVSVPVWAVAGVLMSVLTLLRSGALKHLSSWR
>NC_021191.1|WP_015618553.1|505951_506749_+|ABC-transporter-ATP-binding-protein
MIRAVSDQDIQPPGYAWSVDAAELRVKAGKHLAVNGLNLSLSTGVHGLLGPNGAGKTTLMRALSTVIKPEGGDLRLLGTDVRHDSGLRKLRTKLGYLPQNFGFYPKFTVRDYVEYMAWLREMPKRAVPAATQRAIDRVGLTERADSRLKSLSGGMLRRAGIAQAIVNDPAVLLLDEPTVGLDPEQRVEFRTLLRELGADSCVVVSTHLVEDVVAACTDVVVMDSGSSVFQGVPADLIRLGDSGGIGDSPAERGYSVLLRRHRGGA
>NC_021191.1|WP_015618554.1|506748_508101_+|hypothetical-protein
MAGPARIELRRSNALALGFVVAVVAAAWLGGQTGHWWRQWNWFAVMVTSAMFVLAPLGLAGGAMFGRRDGHTRADELIGSTGRPRWQRVLPGIAVVTIATIAAYLLVLVAGTVAVAVSGSYLGVAGLLAILVDVVVLAGAVSVGIGAGRAWPSPMVPPALAVIGLVVQLVGDTITRPDNSATPLAALSMLVQPPGADWETASLAAVLGRLALGAGLLAGGCLLTAGASRLIRAGGLAAVAAGVAVTMAVSPTAASQPTNRIDAAAQRLICSDGGPQVCVTAVHAYLLTSVVPQARAALTKLAKLPDAPTRAVEWHADTVGTGDDADYLGDTPKTEPGTVFFRLDLSEQEQDTDIEASILNGAGTTANGCRFDDPDALWAAGAWLAGGDTLDVQDFVFGMKLFPDDYQPVLKKLRQAPAKEQLRRVTAMRDAANACRTSNLTAILTGESAG
>NC_021191.1|WP_015618555.1|508097_508718_+|hypothetical-protein
MTRWTALYARSRRLPAAIAISAVAVAVVAGAWRLFSDSPATPANLAVGVGLLVLAPLIPTLSGDDDALESTAALPWPPRRAAHLVALFAGGVALLAVAAALGCEFGTGWQIVRNGAGLTGLIGLGAALIGTQLAWLVPVVWTGIQVMGAAAAAGGGVGQQLLLWQLQPDSSRAAAVLAAVLAVAGLLTYAIRGCPRRSAGEATIGQ

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_4

668602-668704

Orphan

Consensus_repeat	Method
GGCCGGAGGCGGGGGAGATCAGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_4

>merge|NC_021191|4|668602-668704|CRISPRCasFinder
GGCCGGAGGCGGGGGAGATCGGCCACGATCTGAGGCTGCGGCCGGAGGCGGGGGAGATCAGCCGCGATTTCGGCGTGCGGCCGGACGTGGCGGAGCCTGACCG

>NC_021191|4|4|668602-668704|CRISPRCasFinder
GGCCGGAGGCGGGGGAGATCGGCCA	CGATCTGAGGCTGCGGCCGGAGGCGGGGGAGATCAGCCGCGATTTCGGCGTGC
GGCCGGACGTGGCGGAGCCTGACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015618681.1\|677399_678200_+\|integral-membrane-protein	unknown	unknown	gnl\|CDD\|380435
NC_021191.1\|WP_015618682.1\|678215_679013_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213231
NC_021191.1\|WP_015618679.1\|673945_674437_-\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NC_021191.1\|WP_015618664.1\|645346_649306_+\|type-VII-secretion-protein-EccCa	unknown	unknown	gnl\|CDD\|274858
NC_021191.1\|WP_015618666.1\|650717_652082_+\|type-VII-secretion-protein-EccB	unknown	unknown	gnl\|CDD\|368288
NC_021191.1\|WP_015618665.1\|649302_650709_+\|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl\|CDD\|274855
NC_021191.1\|WP_157408689.1\|669819_671382_+\|M1-family-peptidase	unknown	unknown	gnl\|CDD\|341066
NC_021191.1\|WP_041831834.1\|671407_672007_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NC_021191.1\|WP_015618668.1\|655667_658964_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|163057
NC_021191.1\|WP_015618677.1\|672447_673917_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NC_021191.1\|WP_015618680.1\|676857_677403_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NC_021191.1\|WP_015618672.1\|665481_665835_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015618673.1\|665995_666619_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_021191.1\|WP_015618678.1\|674548_676780_+\|bifunctional-diguanylate-cyclase/phosphodiesterase	unknown	unknown	gnl\|CDD\|238923
NC_021191.1\|WP_015618683.1\|679009_680341_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340879
NC_021191.1\|WP_015618670.1\|659268_662715_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|276938
NC_021191.1\|WP_015618669.1\|658979_659282_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|376829
NC_021191.1\|WP_041831837.1\|680337_680952_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_041831832.1\|644984_645350_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|178945
NC_021191.1\|WP_157408688.1\|662772_665118_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226156

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015618681.1\|677399_678200_+\|integral-membrane-protein	gnl\|CDD\|380435	cd20301, cupin_ChrR, anti-ECFsigma factor, ChrR , cupin domain. This family contains bacterial anti-sigma factor ChrR from the photosynthetic bacterium Rhodobacter sphaeroides (Rsp) and similar proteins. ChrR is a member of the ZAS (Zn2+ anti-sigma) subfamily of group IV anti-sigmas. It inhibits transcriptional activity by binding to the Rsp extra cytoplasmic function (ECF) sigma factor E (sigmaE), an essential factor to mount a transcriptional response to a singlet oxygen and for viability when carotenoids are limiting. ChrR comprises two structural and functional modules; the N-terminal anti-sigma domain (ASD) binds a Zn(2+) ion, contacts sigma(E), and is sufficient to inhibit sigma(E)-dependent transcription. The ChrR C-terminal domain adopts a cupin fold, can coordinate an additional Zn(2+), and is required for the transcriptional response to singlet oxygen, a potent oxidant that damages cellular biomolecules and can kill cells. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	0.000605992
NC_021191.1\|WP_015618682.1\|678215_679013_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213231	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	4.45665e-100
NC_021191.1\|WP_015618679.1\|673945_674437_-\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.67008e-32
NC_021191.1\|WP_015618664.1\|645346_649306_+\|type-VII-secretion-protein-EccCa	gnl\|CDD\|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NC_021191.1\|WP_015618666.1\|650717_652082_+\|type-VII-secretion-protein-EccB	gnl\|CDD\|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	1.03706e-62
NC_021191.1\|WP_015618665.1\|649302_650709_+\|type-VII-secretion-integral-membrane-protein-EccD	gnl\|CDD\|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	1.33094e-32
NC_021191.1\|WP_157408689.1\|669819_671382_+\|M1-family-peptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	4.53365e-135
NC_021191.1\|WP_041831834.1\|671407_672007_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	7.77773e-14
NC_021191.1\|WP_015618668.1\|655667_658964_+\|AAA-family-ATPase	gnl\|CDD\|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	4.41006e-87
NC_021191.1\|WP_015618677.1\|672447_673917_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	9.2915e-75
NC_021191.1\|WP_015618680.1\|676857_677403_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	3.71968e-29
NC_021191.1\|WP_015618673.1\|665995_666619_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.527e-24
NC_021191.1\|WP_015618678.1\|674548_676780_+\|bifunctional-diguanylate-cyclase/phosphodiesterase	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	5.17263e-89
NC_021191.1\|WP_015618683.1\|679009_680341_+\|hypothetical-protein	gnl\|CDD\|340879	cd17321, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0.00337171
NC_021191.1\|WP_015618670.1\|659268_662715_-\|AAA-family-ATPase	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	1.96646e-34
NC_021191.1\|WP_015618669.1\|658979_659282_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	4.32994e-16
NC_021191.1\|WP_041831832.1\|644984_645350_+\|hypothetical-protein	gnl\|CDD\|178945	PRK00247, PRK00247, putative inner membrane protein translocase component YidC; Validated.	0.00882809
NC_021191.1\|WP_157408688.1\|662772_665118_-\|AAA-family-ATPase	gnl\|CDD\|226156	COG3629, DnrI, DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms].	4.79064e-23

>NC_021191.1|WP_015618673.1|665995_666619_+|response-regulator-transcription-factor
MEQIRVALQASDPLSHAGLASYLQSRPDLILVRSAERADAKVLVVSCDRLTSEVVAMLRRSAAEFSTPVVLVTGEITENELLTAVECRVVAILPRAAVTADRLAHSVLAAANGGGVMPPNLVGELLKHIERLQRDVLTPNGLNASGLTPREIDVLRLMADGLDTNEIAGELCYSERTVKNVIYGVTHRLKLRNRSHAVAYALRAGMI
>NC_021191.1|WP_015618672.1|665481_665835_+|hypothetical-protein
MAADNELSLSPFAGELFLTLAAEGRLVVDSVRADEAIAALERTLSAARARLRVLRIWQHAPAQRVNDLPLELADDVVDAVFADQLAPGRLEQAVVELPKYIEALRQARRLVPPGDPA
>NC_021191.1|WP_157408688.1|662772_665118_-|AAA-family-ATPase
MDLRLLGPVRAWRDGTELPLGSARRLAVFSVLALHANRAVSREQLVTALWGENPPASATGNVYTYVSALRRVLEPSRDRWAAGQVLTSGGGTYRLSVREQDVDVFRFEALRGEAKQHRATGDRQAELTVLAAALQMWHGEPLAGVPGPFAEAQRLRLSELRLATAERHATLLIETGRLDEAIAVLRALVATYPLQENLQAMLATALQAAGRPAEAQRHAAPSPAPARTAAATAGRGPWPVPSDRASLIGRDAEIRRLRRAVAEVADGTGGSLRIEGTPGMGKSALLTVALRGATPAGCRAGWAVGDELSQRMPLGLLLECFESAMPGDTNPDLVKLLFAVAAEAVDGPSGDIVARAAELVRRAAEQAPLILVADDLQWADPLTLGVWSALHADTRELPLLLIAASRPGGSAVARPTESAAGQPADSEIDRTGGSETDRSGTGDLNAVPVDEVVTLAPLSPAAATQLIRAVAPEPLDPRTFRDMLTDAGGNPSYLRHLAAGGFESMTLSAAVGTQLASFSEEARQLLRAIAFLGAGSDTDPGCTLTELALVTDRSRDDLIRALTPAVTAGVLTAAGEWVAFWHRVVARVLHDGTPTSLRVMLHRSFASRLADTAAPPERVVAQLLAGPVPLDSAIARWLTVHIEQLAGRAPHLAVNVLQRARAQYTVAPAERLELTAWLARLLLAQGRNGAAEAGWVAARTPDPELEGEMRWVAAVSHERRAEYEAAADIARSVLREHRVPPRWIDRFRHLLTRVRPYLAGNPTVPHLSRSAIIGDGVSVIR
>NC_021191.1|WP_015618670.1|659268_662715_-|AAA-family-ATPase
MPTTPDQAPDRRLRVAVLGPVRAWLGDRELSLGAARQRALFAVLAAAAGRVVGRDELIEGIWGETPPATAAGSVYTYISGLRRVLGHDLLTSGPSGYALQLAPEDLDSERYLRLVQRGGELTEAGDLRGAAAVLTEASMLWHGEAYAGLTGHRLELERTRLTDRRLTAIELRARAGIELGEEDAVANLTARVRDYPLHEPLHELLMLALHRTGRRTEALEVFRAARRTLLTELGVEPGPALTELHQRVLTGAAEPAAGRPVPPVLPAQVARALRDGLDGRALTGRDTELAELRQLARDVAAGRGSAVWIEGEPGIGKTELLTAAFADAAELGCQVAWGVADELDQHVPLQVVTRALGLEAMSDDARVATVAQGLHEGNAEDASLAAVADRVLAYVRAACAIAPLVLVVDDLQWADESSVLFWDRLVAATSRLPLLLVAAARPEPSGHELAQLRRSVQNRQGHAYALPALPEPAIEAIVTRLVGAPIGPHLAAVVPRSGGNPLCAREMVTALLRRGAVRVTDGRADIDAAEPVEAPRSLLAVVQATLDFLSADTQEVLRMAALLGAQFAVDDVVAVTGRSPFDLMANLEEALSANVVVDAGDELAFRHPFLRQALYESIPAPARAALHRHTAEVLERGGSPVTRVAEQLAAETPAVDEWVVAWLARRHAEVVKRAPMVAGGLLRQALGTSVPTAEQRAVLLVALVRLEFRSEQWPMDEAREAAEIAGDPADRAEMRQLLAVMTFRRGDQETAIEMLERSLVDPDVPEIWRTRHRVVLANFRRGDLDDLDRADRTAERLRAEAEAADQPYEAAFALQTSWLTHSIRRDHERALEYVDRALDIMRDHPTFAGMYFDLLDNRMFTLQNLDRLDEAERTLREAALFAIRHRLPSSLQVASAVQYYWLGRWDDALAEVSAVTDDAPGITFLGMREPGAVSMLLHGVAALIAGHRDDADLAAGHLDSADVLPATDAERESCDFLLVARALVAEQQDRPAEALDILAPLLVPEYAPMMLRHQWLPDALRLALAQGRRDIAEHAAALCAAEAGKEIRRARAWAASERCRALLAEDPEPALAAAEHYRAVGRVPELAAALEDAAVLLAVNRRPHEAARTGAEAAELYTVLGARWDLRRTHQRLAEVGIDPTRKAVSAG
>NC_021191.1|WP_015618669.1|658979_659282_+|YbaB/EbfC-family-nucleoid-associated-protein
MQPAEMQEFLDHAKAFEQQMRDAQGDLEKAVVTGRSADGSVTVLATGLGKLQAVRVDPGVFDRRDVQALQTAIAEAVQTAADNAGKLATQKMGPVEITLH
>NC_021191.1|WP_015618668.1|655667_658964_+|AAA-family-ATPase
MSRQVLVVGGGKPGAYPTIGAAVARAEPGATITVHPGRYVEKLVVGNRITIAAEGGPVEVTVEEGSVLVVHGEGAQLRGITLASADPKLAAVDVYSGEVALDDCRVSGAAWVTLLARLQGSLALRGCEVRSSTGAGIVVMSTGTSRIEDTVVTDVATSGIVLGEQGALTLRRCTIRGTGANSICVGGDSRLTIEQCEIVQAGKPAVVVEQRGWARIQRLTVKESGNVDLFLRGSVDVVISDSTFTGAALQAAHIADGAAPRFERCTFEAAGHTAAHVTGKSRPTFVDCTFAGSPTGINVDGESAPRFEGATVSGTKEHLAVIGGGAQAVMQRFRGTIAAGAGLVLKDGASLDGTDVAVEAGGAVALDLRASARATIREARFTGTAAAALTIGGGAFLGVQSALVRGAGLAVADGELQVRDSEIVDAPGDGLAVGAGGVVAATQTRVRRARRTGIALAAGSRGTFTECEVLGSGGSGFDVATTEPVTISRCTVQESGGEDVRRAGDAQLTVDALSTARAPQPTPAAPVSAPPRETPAEEAAEPAPDDELSGPLRELNSLIGLRGVKHEVTALINLIKMSQVRLQMGLPMPPMSRHLVFAGPPGTGKTTVARLYGSVLKELGILSKGHMIEAARADLVGQYIGSTAIKTTELVTKALGGVLFIDEAYTLSAGSGGSGPDFGQEAIDALMKMMEDHRDELVVIVAGYSGLMEKFLESNPGLASRFTRTVEFPNYSVDELVTITTNLCNKHYYELTDDGSAALTTYFERIPKNSTFGNGRVARKLFEAMINNQASRLAMAPPTKDSELNRLTAQDVAPELELLEDLPMEQTEQPDAASNPAGAINATKSWHRVCGLVGAAPVRDAVGSALLQLCELRNRRRSYGKHANVIVTGPAGSGRSEFARHYAAGLSELKLVPVGQLIRVTTQQELAPQWPGQAASLVQAAMRDAEGGVLMIDYTDDGTGAAPDIVEQLVTRMRSALGDPVVVLIGEEQALRGLRTAVPAVAEVFGQDWSMPGYSTPELAEIVVRHLVRRGHEVPDDVRAALVDLAAGLPERTVRAAHLFSWGLTRTAASRTLALADLNGIAGRTTPTRQAGGLAAVG
>NC_021191.1|WP_015618666.1|650717_652082_+|type-VII-secretion-protein-EccB
MQTQRDHVHAHTFMVGRLSSALVEGDPTMAEIPGRRAQTGFVIGILLAVLVTGGFAVYGWIVPGGSKAYRTAGAILVEKESGTRYVYVDGALHPTPDLTSAMLIQGADAKVKLISRNSLKDVPRGIPLGVTDAPNEVPPASSLVHGPWLSCLPGSVAGGRKVDGLGVNLEPRTPATPLPQQNFAVVRSGNGTAYLLANYLKYKVEDDAVLVALGAGSIDPVPAPDMWLNWLGDGPALAPARISGAGQDGPAVGGQSYPVGTLFRQQSASGVDQLFVLRKDGLAPMSRTEFLFADAATAGAPVDVDAAAIVDAKKSADRSLLDRLPDLASLKLADANGKALCVQQQPVSAQAFSSVVVFADRYESGINSDGGTYVVARPASGMTVFPAPAASRTTAPPVSFISESGTAYRLAGTETVAALKLNSVTPVPFPKDLLAALPQGPVLSRQAVTGLSRG
>NC_021191.1|WP_015618665.1|649302_650709_+|type-VII-secretion-integral-membrane-protein-EccD
MTTALDGGLCRITVIGPDRKIDLAVPATTSVATLLPVLLNHTTAPGRADADGGEGAWVLQRLGQHPFELSGTPESLDWLEGEELYLRRAEDPLPELDFDDLAEGVATIVNRRNDRWQPEYRRVLFLLLSVVGMGAIAAVLTDRGPTTPQVVAAGVIGAGFFIAALVCARKLTDGAFSLLFGLGAAAFAGLAALSAVDGDPEGIALTGDAVLAFTVGVVAVIAVLLLCQRTVTPYLPPAPMLVVGVTALVAAGVLLLQRASELTAQRTAAIAVAVIFAVIVLAPRAAVKFARLRGPQLPKTGADMAYDIEPAPSDQVRDRTNDADMYLSVALLSSAVLLPVVFHYTMAVPGWAGWTYVLVVASAILLRARTFLGFWQRIALVVAGTVGYLMVIMRLSQTLSLGWRWVLLGALLAAMVPLVMAALRPFPRRMLPFWEYSATFFDVATGIAVLPVLAQILGLYTWARGLFG
>NC_021191.1|WP_015618664.1|645346_649306_+|type-VII-secretion-protein-EccCa
MSTVTIKRPPRAAGPEAPDGQVELQEPPLMAEEAPLDFRSFAMIVPMGLGMGAMMAMFGLYSRAPIMYVMGGAMASGMLLMGVMQIGKAASDRKRKMRGERRDFLRYIAQLRKQARTAADQQRQFVLWNNPQPSWLWSIAMSNRLWERRPSHDDFGRVRIGLGRQNAMLKFTPPSTKPIEDLEPLASISLRRFSEAYRTVNGIPIAVGLTSFTSIEFEGPADPAIDLVRAMVAQLVTFHAPDELRVAVLAAEVHRGPWDWIKWLPHNAHPSAFDAAGPVRMFAGTHDDLMDLLGPEITDRGDHDRNSRPSATEPLVVIIAHLADLPESSRLLGAGMRNVVLLDLTGAMPGGPKVLRLTVENDQVRFPAGDTTGTADRDALDTTKCEALARIIAPKRTSGTLDVVEEPLETSFELTSLLGIRDANTFDVNTLWRTRQPQRNRLTVPIGVTEEGEVIELDLKESAQGGMGPHGLLIGATGSGKSELLRTLVVALAATHSSEILNLVLVDFKGGATFIGMEKLPHTSAVITNLADELPLVDRMQDALQGEMTRRQELLRASGYASLFDYEKARAAGAQLVPFPVLLIIVDEFSELLSSKAEFMDLFVSIGRLGRSLGVHLLLASQRLDEGRINRVEGHLSYRIALRTFSSMESRSVIGVGKAYELPPEPGNGFLKLDTTNLVRFKSAYVSGPYTGRSLTGGAEEEDQQTALDVVPFTTRQVAIRQDRGRARPAETEEVVPESATGPSLLEVILDRLAGSGPPARQVWLPPLSAAPSLDTLLPSVVPDPLRGMTVDDPAAQRRLRVPVGIVDRPQDQLRELLIADLSGADGHVGIAGAPQSGKSTLLRSLILGLALTNTPREVQFYGLDFGGGGLSSVAGLPHIGSIATRMERDRVVRTVQEIGQVMERREAEFAARGLDSMQSYLAARERGEINDPFGHVFLVIDGWYTMKQDFVELETKFQELASRGLSFGIHVVVTATRWSEMRTWLRDLMGTRLELRLGDSMESEVGSRKAATVPNQPGRGLTPDGLHFLGALPRMDGSSDTDDLAEATKSVTEEISTFWAGPPAPTVRMLPTRLAVEQLPAPEREFKICIGEDEQRLAPVWHDFMATPHMLVFGDSETGKSNMLRLVLRAIQQHYRPDQAKVVLGDSRRDLDTAITADYQVGFGFTGDKLYELAGQASVSMNRRVPGQEISSERMRKRDWWEGPELFVVVDDYDLMTKGTGVGSTLDPLLPLLAQGSYIGLHLVVARSTSGAMRAMMDPVIRRMWELGTPATLFSYPKEEGKFLGEAAPRRLPPGRAQLVTRRGVKLMQTGYVEGDRG
>NC_021191.1|WP_041831832.1|644984_645350_+|hypothetical-protein
MPDDTREQAAPRPVWRRAAAAPRVAGSDVPLTCGGGELSVAEHFELMRERKRALDEERARAHEEEEARRASRRSAAAKPDVEDEDEDKAAERFRNDRYAVKLLQQDDGAWGGGGAGPGVLG
>NC_021191.1|WP_157408689.1|669819_671382_+|M1-family-peptidase
MGNRLSVALVAGATVLVTVAGTGLPAEAGGGAPTPGAPGLGDRLYPLLGNGGYDVQNYDLSLTYPAKVPTQAVTGDVTITARATQSLSRFDLDFGGSSVGSVAVDGRTAAFSRSGDELVVTPQRPLAKGKWFRVTVKNFAATPVDASAGEPVGFVSTVDGTVLAGQPNTSHLLFPSNDHPRDKATYTITLTAPVGWIGVANGRHLRDRKHGGFVSSTYRESQPMASELVQVAVGDYVVQNRPAVHGTPIRDVVPRRLASSLLPQADAERSQVAWMESKVGPYPFENYGSLVIDANLGFALETQTLSLYDSGLFSAPPAILNPVMTHELAHQWFGDSVAPSAWSDVWQNEGHATWYELTYADETGTLEEYTGESDLDSFFKDTYAAGDRYRARFGPVAAPARADSIWDLFNPNVYDGGALVLYALRQQVGTATFQRIERAWVTQNKGKSASTADFIALASRVSGRDLHGFLTDWLYGSKTPPMPGHPDWTVTPATAAPSVAARRADQAVTTRLQRLVSASR
>NC_021191.1|WP_041831834.1|671407_672007_+|TetR-family-transcriptional-regulator
MTSGGIRDRFRAQMRVEVKDAALRQLAEGGATALSLNAIAKELGVSGPALYRYFAGRDALLTELILDAYADLTDALRAAPADLAAQAAAYRNWALAQPHRYRLLFSAPLPGYDAHDERLVAAGQRAMDVLLASAAPGPQPPADLARQFTAWSGAADPAAALHAVTWWSRLHGFVSLEIEGNFASMGLDADLLFASTMFW
>NC_021191.1|WP_015618677.1|672447_673917_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MNLAVTSSPVRYGTATGRWVLLATVLGSSLAFVDATVVNIALPAIGRDLGADAAGLQWTVNGYALSLASLILLGGSLGDRFGRRRIFAVGVAWFATASLLCGLAPSVELLVGARVLQGIGGALLTPGALAILEASFAREDRSRAIGAWSGLGGIGGALGPFLGGWLVELADWRLIFLINVPLAAVVLAVTLRHVPESRNPAAARQLDLIGVITGAAGLGGLTYGFTAWPMDGPGNPVVLTALAVGVLGMAGFVLTERRSAHPMLPLGVFRSKAFSAANLVTFLVYAANGGVFFLVVLNLQVVSGFSPLTGGLALLPVTAIMLLLSARSGALGQRIGPRIPMTAGPLVCAAALLWMSRIGAGASYATDVLPPVILFGLGLSLLVAPLTATALGALDDAYAGVASGVNNAVARAAGLLAVAVLPLAAGIGSGSLTDPGTLHPTYRTSMMICAGLMVAGAVLAAIFVPARLPAHTPRFHCDVAGPPVHHNDN
>NC_021191.1|WP_015618679.1|673945_674437_-|response-regulator
MTTVLIADDDADHRELMTLALYRLGHQVIVVTDAEQALRAAAGGGLDAALLDVRMPRMSGIELCRQLRAAPATAQLPIMMVSADVNGDRIMAAMAAGADDYLTKPYHRRELDTRLDALLLRRARPGSRTAAAANAALLAARAALPKPVAAPAVPGCPPLRRTA
>NC_021191.1|WP_015618678.1|674548_676780_+|bifunctional-diguanylate-cyclase/phosphodiesterase
MNWNRAHAVIAGLLVLGVAGLLFLPSPGPVVGTVLATFCAIGIVAGLRAARIPGNDVRTRRGWWVMTAMFGLQLLTTAAFAVPGANRTFPAPGDVLRALDIVVLFVAAYLFPVVTATSLERRKAVLDALTVLASGSMTVWYLVLGRTTHASFQILLAASAFPVLDLLLVLGFTRLVFRGTTALRRNTALLLTLAGLVQFIADAWFGYLTARTGSIEHDAVWQLVSVVVMVALLAAAVVERCRQPEITDPMAERCLTRGYLPYVAIAVGYSLMVAAAVQEHEAFPWSGLTLGGFAITLLVVLRQIAMQRESDQAATTDGLTGLANRSRLRDLLVQALDRDARAGRMTAVLLVDMNGFKQVNDTRGHKTGDQLLIGFARILRDAILGADVAGRLGGDEFAIVLHDIGSEANAEAVARRIAAAAEEPVAVDGAAIRASASIGIALAGPGEFTADELMHRADVAMYHAKRRGGDTRWASYAETMGGGDEPSLEDELRVAAGAGQLRLVFQPIVGLPDEDLAGVEALARWEHPRLGLLDAEAFIPLAERIGVIADIGRWVLREACSCARRWPQLPLHVNVSGRQLEEDGFSTEVREIVQATGMNPAQLVLEVTESQLIADGVPAAHLRILSDEGIRIALDDFGTGYSSLKNLTHLPIDMLKLDRVFVATLDASAEGAAVAQAVLRLGRVLGMDTVAEGVETAEQARELTLLGAGKAQGHYFARPLPPAEIDARIAAWSDHRYGRSVRA
>NC_021191.1|WP_015618680.1|676857_677403_+|RNA-polymerase-sigma-factor
MTEVGEEQLLRRVARADRAAFDELYRRTSPWLAVRLRRRCADDGIVAEVMQDTYLAVWRAAGSFTGAAGPTGGSAAGWLWTIAARRLVDALRKRARTREVPAEDLPMRTAPAAEDEALAGTVGDEVGAALSRLAPELRKVLHAMVVDGLTVRETSILLGLPEGTVKSRARRARNELREALS
>NC_021191.1|WP_015618681.1|677399_678200_+|integral-membrane-protein
MIDHIPAATLAAYSAGEPQLDDATVWVVEVHLESCGHCRSTLAGQAAPDLLGLLDDVQVRIDRGVRTGPRPARGHAWRRLVHRWAAWAIVPWAALVVTVVLAAFLLDRAYPERPSLVLLLAPVAPLAGLAVTWSRRTDAAAEVIAGTARAGLELLLRRTVVVLVLILPPLAVAGWCLGMSPARWLLPCLTFTAATLLLGGRIGVTMAAAVLGIGWLTVVIVPAMLTARLPVLVQAASLPGWLAAAVIFTALMIWRADDHQRLESWR
>NC_021191.1|WP_015618682.1|678215_679013_+|ATP-binding-cassette-domain-containing-protein
MVRTVNVSELAPTAYAWPVEAEGLRVKAGRHLAVDGLDLQLGTGVHGLLGPNGAGKTTLMRALSTVNKPSGGRLRLLGTEASDGRALRPLRRRLGYLPQHFGFYPRFTVREYVEYMAWLREMPADAIPAAVQRAVDRVGLADRAGARLKTLSGGMLRRVGIAQAIVNDPALLLLDEPTVGLDPEQRVQFRELLRDLGTDSCVVVSTHLVEDVVAACSDVVLIAEGKLVFQGLPEDLIRLGEQGGTGDSPAERGYTTLLTNHRSAS
>NC_021191.1|WP_015618683.1|679009_680341_+|hypothetical-protein
MIHLTWTELRRSNARTLAILLIAVSAVLLALDGMWRGQWLRLIYNHDSSLFVLLPLALAGGAILGRRDRRTGVHELVGATPRPRVARTVPPAAALAAAAAGAHLLIFAVATVIVAVNGSYLSVAPIAMALAGAVVLVGGTWLGLAAGRAWSSPLVPPALAVLGLVLQFSASESTPGELNRLSNLSLLAQPPGSDWEAPTAQAVFSRLALGVGFAAAGFLLTAGSSWLPRVVAVPVLAGALVAAAVLPGTTMAGRYRIDPGAERLVCSGQVCLTAAHANLMDEVAPQVRRALTLLAKLPGAPQRAVEWRSDRVWELGDSIDAAGAQRAEPDILQIDLDLGNGKPGPHLTESALLGAGTRWNGCYNGESVAQYAAGAWLLGTDDMVVYDGFGAPPGDFGAEVRQTVAKLRQLPPDEQVRRVTALRDASADCVQDLMPYLTDGVRP
>NC_021191.1|WP_041831837.1|680337_680952_+|hypothetical-protein
MTRWLPLYLRSRRLPVALPAALAGIAVMWGGWSFFTDRREVPVSLTVLTVALALAPLIPTLSSDDDSLEATAARPWLPRRMTHLIAGCVVVAALVAATRTTGAWFGPTGVVLRDAAGLTGLIGLGVALGGVRLAWQVPVSWTAMQMLIGESGSTGWRQVVFWETQLPGNRVAAVTAGLFLLSGVLAYGLRVGPRIAPAEATMVQ

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_5

1943594-1943813

Orphan

Consensus_repeat	Method
GACCGTGCCCGGACCGACGGTCGCGCCG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NC_021191_5

>merge|NC_021191|5|1943594-1943813|CRISPRCasFinder
CGCAGTGCCGGGATCGACCGCCTCGCCGGGGATGCGAGTTCCATCGGGGCCAACGGCAGTGCCGCGACTGACCGTGCCCGGACCGACGGTCGCGCCGAGGACGAGAGTCGCGTCGGGGCCGATGGCCGCACAGGGACCGACCGAGCCCGGACCGACGGTCGCGCCGGGATCGAGGGCCGCTCCGGAATCGACCACCGCGCCCGGAACGATGGCCGGGCCG

>NC_021191|5|5|1943594-1943813|CRISPRCasFinder
CGCAGTGCCGGGATCGACCGCCTCGCCG	GGGATGCGAGTTCCATCGGGGCCAACGGCAGTGCCGCGACT
GACCGTGCCCGGACCGACGGTCGCGCCG	AGGACGAGAGTCGCGTCGGGGCCGATGGCCGCACAGGGACC
GACCGAGCCCGGACCGACGGTCGCGCCG	GGATCGAGGGCCGCTCCGGAATCGAC
CACCGCGCCCGGAACGATGGCCGGGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015619849.1\|1936688_1938083_+\|endo-1,4-beta-xylanase	unknown	unknown	gnl\|CDD\|366032
NC_021191.1\|WP_041833323.1\|1931664_1932069_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223509
NC_021191.1\|WP_084504064.1\|1940541_1941213_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NC_021191.1\|WP_015619858.1\|1946007_1946634_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_021191.1\|WP_015619856.1\|1943958_1944609_+\|DUF4281-domain-containing-protein	unknown	unknown	gnl\|CDD\|379473
NC_021191.1\|WP_015619846.1\|1935026_1935491_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239316
NC_021191.1\|WP_015619859.1\|1946717_1947116_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226318
NC_021191.1\|WP_051167386.1\|1935896_1936232_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_157408739.1\|1944862_1946011_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_021191.1\|WP_015619844.1\|1932144_1934433_+\|transketolase	unknown	unknown	gnl\|CDD\|223101
NC_021191.1\|WP_041832034.1\|1951897_1952479_+\|flavoprotein	unknown	unknown	gnl\|CDD\|235513
NC_021191.1\|WP_015619862.1\|1948206_1949133_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NC_021191.1\|WP_015619852.1\|1939915_1940440_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225097
NC_021191.1\|WP_015619845.1\|1934527_1934959_+\|DUF3052-domain-containing-protein	unknown	unknown	gnl\|CDD\|378615
NC_021191.1\|WP_041832033.1\|1949250_1949673_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_041832032.1\|1941283_1942513_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NC_021191.1\|WP_015619860.1\|1947388_1948231_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015619863.1\|1949746_1950421_-\|bifunctional-DNA-primase/polymerase	unknown	unknown	gnl\|CDD\|214927
NC_021191.1\|WP_015619864.1\|1950666_1951896_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224314
NC_021191.1\|WP_157408738.1\|1938106_1939417_+\|PHB-depolymerase-family-esterase	unknown	unknown	gnl\|CDD\|273828

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015619849.1\|1936688_1938083_+\|endo-1,4-beta-xylanase	gnl\|CDD\|366032	pfam00331, Glyco_hydro_10, Glycosyl hydrolase family 10.	3.2705e-149
NC_021191.1\|WP_041833323.1\|1931664_1932069_-\|hypothetical-protein	gnl\|CDD\|223509	COG0432, COG0432, Uncharacterized conserved protein [Function unknown].	3.50078e-33
NC_021191.1\|WP_084504064.1\|1940541_1941213_-\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	6.81114e-16
NC_021191.1\|WP_015619858.1\|1946007_1946634_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.79483e-67
NC_021191.1\|WP_015619856.1\|1943958_1944609_+\|DUF4281-domain-containing-protein	gnl\|CDD\|379473	pfam14108, DUF4281, Domain of unknown function (DUF4281). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 147 and 232 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.	1.67341e-50
NC_021191.1\|WP_015619846.1\|1935026_1935491_+\|peroxiredoxin	gnl\|CDD\|239316	cd03018, PRX_AhpE_like, Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater similarity to 2-cys PRXs than 1-cys PRXs. PRXs are thiol-specific antioxidant (TSA) proteins that confer a protective role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. The first step of catalysis is the nucleophilic attack by the peroxidatic cysteine on the peroxide leading to the formation of a cysteine sulfenic acid intermediate. The absence of a resolving cysteine suggests that functional AhpE is regenerated by an external reductant. The solution behavior and crystal structure of AhpE show that it forms dimers and octamers.	4.65109e-74
NC_021191.1\|WP_015619859.1\|1946717_1947116_-\|hypothetical-protein	gnl\|CDD\|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	5.1722e-11
NC_021191.1\|WP_157408739.1\|1944862_1946011_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	5.71981e-31
NC_021191.1\|WP_015619844.1\|1932144_1934433_+\|transketolase	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	3.43924e-62
NC_021191.1\|WP_041832034.1\|1951897_1952479_+\|flavoprotein	gnl\|CDD\|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	1.29539e-20
NC_021191.1\|WP_015619862.1\|1948206_1949133_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	7.96678e-48
NC_021191.1\|WP_015619852.1\|1939915_1940440_-\|hypothetical-protein	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	0.00707486
NC_021191.1\|WP_015619845.1\|1934527_1934959_+\|DUF3052-domain-containing-protein	gnl\|CDD\|378615	pfam11253, DUF3052, Protein of unknown function (DUF3052). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.93068e-59
NC_021191.1\|WP_041832032.1\|1941283_1942513_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.83534e-49
NC_021191.1\|WP_015619863.1\|1949746_1950421_-\|bifunctional-DNA-primase/polymerase	gnl\|CDD\|214927	smart00943, Prim-Pol, Bifunctional DNA primase/polymerase, N-terminal. Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities.	7.39871e-19
NC_021191.1\|WP_015619864.1\|1950666_1951896_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224314	COG1396, HipB, Predicted transcriptional regulators [Transcription].	8.69333e-08
NC_021191.1\|WP_157408738.1\|1938106_1939417_+\|PHB-depolymerase-family-esterase	gnl\|CDD\|273828	TIGR01840, poly3-hydroxybutyrate_depolymerase_A_precursor, esterase, PHB depolymerase family. This model describes a subfamily among lipases of the ab-hydrolase family. This subfamily includes bacterial depolymerases for poly(3-hydroxybutyrate) (PHB) and related polyhydroxyalkanoates (PHA), as well as acetyl xylan esterases, feruloyl esterases, and others from fungi. [Fatty acid and phospholipid metabolism, Degradation].	1.63085e-39

>NC_021191.1|WP_041832032.1|1941283_1942513_+|MFS-transporter
MTDVPMTLWRNREFNLLWASQSLSDLGTAISGLAVPLLVLALTGSPVQAGLVGTLGLVTGVLFRLPAGVVADRFDRRRIMLICDGVRFLAYLLLGVAVLRDRATLAMVIAVVLVASVGNAFFGTAEHSALRSIVPVHQLPTAVARNEARSYATSLAGPPLGGVLFGLGHAVPFVGDAVTFLASMLGVALVRRPLQEHREAAPAGHLAALVEGVRFVVGDPFLRTVVLVAAPLNLSLHGVIFTVIVTMQAHHTPPGIIGTVETVVGVGGLLGSLLAPALQRRLPLPVLIRTVCLVAALLMSAGALVTDSVLAAVPVGLATLFGPATNAALFGHQAAITPDRLQGRVVSVIIVLATSIAAAAPLIAGLLIATVGSAAAVLVFAALVAGAAVKATMSRGLRTQTPAPGSTPA
>NC_021191.1|WP_084504064.1|1940541_1941213_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MSGRTGHPRSAPDTSLTGMDLRAAIADERRRIADLLDSLSPGQLDAPSLCGDWTVKEVAGHLVAATGRPAFGFLAKNGFNLHKANSRLAVQTAERPVAELAQALRDTADTIAKAPIVGYPGQLTDAQVHGQDMRRPLGLPHGLQLDRLKVSLDFMVGGHAIGFAPKRRLAGLRWEASDLNWFSGVGPLVAGPAEALLMAMCGRGAVLPELDGPGVRILDRRIA
>NC_021191.1|WP_015619852.1|1939915_1940440_-|hypothetical-protein
MTDIGYAPELDRRPHTMLERHLTVGAHTYQITASGTGEETVSLALSGWSSDGQVVSEISGGISPHDLPAVAAALTSTLAGLVALHDQGKAAGTAAPAKPKRYPNRGSRWSPADDERLLARFREGARERELMEEFGRSRGGIRARLETLGELEPGTGGVLRARGAQPDPQGGGTD
>NC_021191.1|WP_157408738.1|1938106_1939417_+|PHB-depolymerase-family-esterase
MIGALVGAFALVAGVLVAAPPASAASLVEVTSFGTNPTGLRMHIYVPDNRPAKPALLVAVHYCTGSGPAFYSGTQFASLADRYGFIVVYPSATRSGSCFDVSSPGALRHDGTSDPVGIVSMVRYAQQQYGADPARTYVTGASSGGMMTNVLLGDYPDVFKAGAAFMGVPFGCFATTDGSSWNTACAQGQITKTPQAWGDLVRAAYPGYTGTRPRMQLFHGTTDDTLRYPNFGEEIKQWTNVLGVSQTPVLTDTPQSGWTRTRYGSASVQAPVEAISVAGVGHSLPLSGQAELAIKFFGLDSTGPSQPTPSQPTPSQPSPSQPSPSQPSGPASTCRVTDTVSAWNTGLTSSITITNAGTTAISGWQLGFTLPQGQTITSGWNATFAPSTGAVTATNASYNAQIAPGASVGIGFQATHTGNTAGPAAFTLNGTACSLS
>NC_021191.1|WP_015619849.1|1936688_1938083_+|endo-1,4-beta-xylanase
MTLDPARHRGRRTSRLRGVVLTVAAGTVAVGAALTLSGTADAATTLGASAAASGRYFGTAVAAYKLSDATYLGILNTEFTMVTPENEMKWDATEPAQNSFSYTNADRIVSQATSMGARVRGHALAWHQQQPSWVQSLSGTALRNAMLNHVTQVATHYRGQIYAWDVVNEAFADGGSGARRDSNLQQTGNDWIEAAFRAARAADPNAKLCYNDYNTDGQNAKSNAVYAMVQDFKSRGVPIDCVGFQSHFNAQSPVPSDYQANLQRFADLGVEVQITELDIEGSGTAQADSYARVTQACLNVTACKGITVWGIRDSDSWRASGTPLLFDGNGTKKQAYTSVLTTLNGGTEPSTPPSTPGSPSTPPPSGGACTATLSNNAWNGGFVTTVKVTAGSSALSGWSVTVTLPSGAAVTSAWNSQSSGTTGAVRFANASYNGRVTAGGSTEFGFQGTGTAPSIVPACTASLG
>NC_021191.1|WP_051167386.1|1935896_1936232_+|hypothetical-protein
MEFADGQREAIRDVLRRRVDGFYDRGWSEVSGPNGDVCFVYCGTIREAGGEWLLGQLAEIALIPAPATDPEDAIRGLFLVHHEQTGMQEWQIRDGQVVVAALPKRYDYLQK
>NC_021191.1|WP_015619846.1|1935026_1935491_+|peroxiredoxin
MSIDVGDQAPDFTLKDQNNQEVSLSDFRGRKAVLLVFYPLAFTGTCQGELTEIQENYSEYSNDYIQVLTVSVDSVYSHKIWADREGFTFPLLADFWPHGGVAQAYGVFNEDAGFANRGTFIIDKAGTVRFAQQQGPGEPRDQKTWRDAFQGLAG
>NC_021191.1|WP_015619845.1|1934527_1934959_+|DUF3052-domain-containing-protein
MSATAGQADGVRSLADRFGFEPTMVVMEMGYDDDVDEDLRDALTERVGELVDEDTDEVVDAVLLWYRDGDGDLFELLTDALSPLADSGVVWLLTPKAGRDGHVEPSEVSENAPTAGLQQTSTVNAGKDWTAARLVSSRGAKKK
>NC_021191.1|WP_015619844.1|1932144_1934433_+|transketolase
MLVRVTTPQQLDERFRDAVAALRPTGSARAPGDPVRDGSALTGERARELFDAQLTSRHLDLAARWLRSFNEGFYTIGSSGHEGNAAVAAVLRPDDPALLHYRSGAFYCVRAAGVLDPGPESDAMAEAARDVLRGVVASAAEPISGGRHKVFGRSELQIVPTTSTIASHLPRAVGIAYGMSTVPALRGVRSPWPSDAIVVASFGDASVNHATATAAFNTAGYLQHTGRQLPLLLVCEDNGWGISVPSPGGWVAETLRTRPGLRYFAADGTDLAAAYDTAREAAGWVREQRRPAVLHLSTVRLMGHAGADAEVAYRAKDDISRDVDRDPLIGTARLLVEGGFATVDDLITRYDELGWQVRKVAEEVLGEPKLTSLAEVAAPLAPRRPLRVARHVADAAGRASGIGSAARPTAFAGKLPEQAGPLTLAQTINATLTDALLTHPGAVVFGEDVAVKGGVYGVTKNLRDRFGPDRVFDTLLDETSLLGLGLGTGLAGLLPIPEIQYLAYLHNAEDQLRGEAATLQFFSQGAFRNPMVVRVAGLAYQQSFGGHFHNDNSVAVLRDIPGLVLAVPSRPADAAPLLRSCLAAAAVDGTVSVFLEPIALYHTRDLYQQGDNEWLAPYAAPGEWAGAHIPIGRARTYPVGSAEDLTILTFGNGVRMSLRVAAQLAAEGYGSRVVDLRWLSPLPVADLVREAAATGRVLIVDETRRSGGVGEGILAALVDGGFVGAARRIASADAPVPLGPAAQQVLIGEDAITQGAHALLAR
>NC_021191.1|WP_041833323.1|1931664_1932069_-|hypothetical-protein
METTVITVRTGSEPVVRDITGEAEQFARGRGDGLLHVFVPHATAGIAIIETGAGSDEDLLTAIDDLLPAEDKWRHRHGSRGHGRDHVLPAWIPPYATLPVLDGRIALGTWQSICLVDPNGDNPERQVRFSFLQG
>NC_021191.1|WP_015619856.1|1943958_1944609_+|DUF4281-domain-containing-protein
MSETLFSLTFAVAAPFWAMMIVLPRWAWTRRIVASPWIVLPPVLIYAIVVAGSLGDVLPAVISPTLPGVRELLGTSDGATAGWAHLLAFDLFAGRWAYLDSRERGIPPLVMAPILLLTILLGPLGLLTFLLVRRRWPDPTVGRRDGETDLGRRMGESGMWRRGSETGVGRRQGESGVRRRGGESGVRRRGGEAGLGRRGGEAGEWWSAGGSGVGDA
>NC_021191.1|WP_157408739.1|1944862_1946011_+|two-component-sensor-histidine-kinase
MIHRVGAGWTLLELTLAGSPLLQDQATDQHAKERQAKEQQARKQQATERQAAEGHAPEGPAANRQAAEGLAAERQPIERQATARQAAKRRWWAAGALCAVYLAAAWGEPAGQWVQRVFGLVFGVGVPVLLGTVIRTSAELAWQSAVSAREEHRRRESEARAARADERGAIARELHDVVAHHVASMVLRVGVARHVLPDLDARTREVFDDVHETGTTALEDLRRLVAVLRRPGDARIDPSLTAIEPGALPAALDGAVETARRAGLVVDADIDREVAGLDAVRGLAVLRLTQEALTNVTKHAGGAARVRLVVAIDRGDVFWEVTDDGGGLPGGGPVGTPPVPAVNGGHGLTGMRERVAVLGGDLQAGPAGGGWRVRTTLPGVAS
>NC_021191.1|WP_015619858.1|1946007_1946634_+|response-regulator-transcription-factor
MIRVLLVDDQQLIRAGLRMLCDAQPDMEVVGEAGNGRDAVLLAERLTPDLIVMDLRMPGLDGITATGRIVAARPGARVLVLTTFGDDDHLYPALTAGACGFLLKDAAPADLLDGIRRAAAGDSAFSQDVLHRLVQRAVQARAGAPRSAPGLTARERDVLALVAEGLSNTEIAGRLHIGVTTVKTHVTSLMTKTGSPNRVRLALYAHGA
>NC_021191.1|WP_015619859.1|1946717_1947116_-|hypothetical-protein
MLYLLVVDYQPGAVTTPMEEWTPADIKAHMDYFDELNAELLKTGEYVGGHALTGPQLAKVVTSDGTGPVVTDGPLTGAERMPAGYQLVDVATEDRAIAIAARISAVPGPGGVPMQQPISVRRVISADDFATL
>NC_021191.1|WP_015619860.1|1947388_1948231_+|hypothetical-protein
MPLFIGADYEKTVVSPYPLKMRAGRARRYRYGSVTEVVPRSPSGRTRPERTRDAGQLALVLIVVTALVSALGVPWLAIASGCAILFLAMTGRRRRAAQPGTVALPRGDAADVLYAPQERAAYGRAVATARRVRKTWPALHHMIDPDEADRGLTTALRDLASVLARRQQIRRLRDELEQAAAHGLAPDSPAARALAEQRDRVAELWRESGDDANRILAAVHAAAVAGENLIRELRVHQTARDAELAISRLTAAAGPASDAAPELAGRTAAVIAAYRELTGG
>NC_021191.1|WP_015619862.1|1948206_1949133_-|NAD(P)/FAD-dependent-oxidoreductase
MTYDVIIIGGGPAGSSAAVALGRALRSVLVIDAGRPRNAPAEGIHNFLTRDDIAPAEFRALSRAEVTRYGGEIVDGTVTTAGRDGDHLVVTMTNGQTFQSRRLLVTTGLTDELPDLPGLRERWGHQVIHCPYCHGYEVRGKAIGVIGTSPMSLHQAQMWRQWSDDIVYFQHTGPAPEPPASDAFAARGIRTVTGTVAEVTDAGVRLTDGTVVARDALVVAPRFLTNGGFLESLGLETTPHDFGTTVVAEPDGRTTVPGVWLAGNVTDPMAQVISAASAGLSVAAAINMDLIAADTAAAVAAQPPVSSR
>NC_021191.1|WP_041832033.1|1949250_1949673_+|hypothetical-protein
MRRRFITPIAVLTGLFGLGAASANAAGRVAADDQQKTAAVVPAATPSAGLKLIAGYSGSTHWYGPRLTLPARKYEAIATYTCDNGGFLYVSWNGEPYSYESAKSSDGSGTVVLQGVDGGTRGYFAVDSWLGCAWTMKVYA
>NC_021191.1|WP_015619863.1|1949746_1950421_-|bifunctional-DNA-primase/polymerase
MQWSTSLIDRIRLRRAAQRYAMHGWAVTPGAYPTGGRFTCGRAGCRIMGCHPAVESWEDDASTDVARVAGWWRQHPYTVLLATGSGFDVLEVPAAVGLRVLGAVRLHTGVIGPEQGDARGPVAVTPSGRWMFFVLPDGELRPELASCLDILHHGRGSWIPAAPSRTPEGPVRWAVAPEQIGWHLPGSATVQAMLLDALDALGRRPPRPVALSVPRQMSTARRAA
>NC_021191.1|WP_015619864.1|1950666_1951896_+|helix-turn-helix-transcriptional-regulator
MDELPIGRRVAYWRGRRKMSQQVFADRLGKSKSWVDKVERGVRRLDKFSVVYEIADVLAIDVTLLLGKDVERRPDTPNCIDQVEVEEIRAALERYDQMSAFFHPIPQAPPLTEMRKAVSHAWLTYQHAKYGVLARKLPQLLRDAQAADSAHAGGDEARDAAHLLGQVYQIASSALRKVGEHELSWLAADRSIAVSQRAGDQLLAGMASHRVGMALLSLGRVRSALEVNVNIANRLAPLSPEAATPERLSVYGLLLLTGAMAAARIGDSATVRDLVSGAEQAACALGGDYNYYWTSFGPTNVELHRAAAAVELGDGGKAIETHERIDKGSFAAMLPERRAHHFLDIARGYTQLGDVEKASEMLLEGDRLAPSEIRCRPLAHEVISDVLRRTRGTPPAPIAELAEQMGVGV
>NC_021191.1|WP_041832034.1|1951897_1952479_+|flavoprotein
MGSAVSPGVLYVLVCGSPIARDVGLLVELAQRDGWEVCVITTPDGRKFVDTAALHAQTGHPVRSYYKNPGDEDLLPPADAMIVAPATVNTVNKWAAGITDTLVLGLLVEGYGFNTPTVVVPYTNKVMALHPAFHESLAKLRTWGVHVLHGDDVVRLGMPGQNDRFRKQFPWRRALQVLQTHFETVDRVEPGAR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_6

1971802-1971900

Orphan

Consensus_repeat	Method
AGGCCCGGCCTCGGTCGCGCGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_6

>merge|NC_021191|6|1971802-1971900|CRISPRCasFinder
AAGGCCGGCCTCGGTCGCGCGGGCCCGGCACGGTCAGGCCCGGCCTCGGTCGCGCGGGCTCCCGGCCAGTCAGGCCGGGCCGGCCTCGGTCGCGCAGGC

>NC_021191|6|6|1971802-1971900|CRISPRCasFinder
AAGGCCGGCCTCGGTCGCGCGGGC	CCGGCACGGTCAGGCCCGGCCTCGGTCGCGCGGGCTCCCGGCCAGTCAGGC
CGGGCCGGCCTCGGTCGCGCAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_157408274.1\|1969034_1970036_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_021191.1\|WP_051167388.1\|1970109_1970685_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NC_021191.1\|WP_015619880.1\|1967253_1968255_+\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|273112
NC_021191.1\|WP_015619877.1\|1963096_1964353_-\|glycoside-hydrolase-family-18-protein	unknown	unknown	gnl\|CDD\|119365
NC_021191.1\|WP_015619879.1\|1965192_1967058_-\|fluorothreonine-transaldolase	unknown	unknown	gnl\|CDD\|275299
NC_021191.1\|WP_041833330.1\|1968381_1968885_-\|YbaK/prolyl-tRNA-synthetase-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|239828
NC_021191.1\|WP_015619886.1\|1973139_1973682_+\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028
NC_021191.1\|WP_084504065.1\|1971945_1972830_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_021191.1\|WP_015619884.1\|1970971_1971613_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015619894.1\|1981916_1982978_-\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|223135
NC_021191.1\|WP_041832040.1\|1973844_1974741_+\|adenosyl-fluoride-synthase	unknown	unknown	gnl\|CDD\|275300
NC_021191.1\|WP_041833334.1\|1976252_1977230_-\|carbohydrate-kinase-family-protein	unknown	unknown	gnl\|CDD\|238917
NC_021191.1\|WP_015619878.1\|1964455_1965172_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366857
NC_021191.1\|WP_015619888.1\|1974809_1976183_+\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NC_021191.1\|WP_015619891.1\|1978457_1979897_-\|adenosylhomocysteinase	unknown	unknown	gnl\|CDD\|377487
NC_021191.1\|WP_015619875.1\|1961116_1962763_-\|sodium:solute-symporter	unknown	unknown	gnl\|CDD\|223664
NC_021191.1\|WP_015619893.1\|1980998_1981907_-\|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|181319
NC_021191.1\|WP_015619876.1\|1962767_1962974_-\|DUF3311-domain-containing-protein	unknown	unknown	gnl\|CDD\|371707
NC_021191.1\|WP_015619890.1\|1977235_1978423_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NC_021191.1\|WP_015619892.1\|1980113_1980983_+\|S-methyl-5'-thioadenosine-phosphorylase	unknown	unknown	gnl\|CDD\|350161

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_157408274.1\|1969034_1970036_+\|EamA-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.13193e-12
NC_021191.1\|WP_051167388.1\|1970109_1970685_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.68943e-14
NC_021191.1\|WP_015619880.1\|1967253_1968255_+\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|273112	TIGR00512, methylthioribose-1-phosphate_isomerase_predicted, S-methyl-5-thioribose-1-phosphate isomerase. The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family].	2.52713e-119
NC_021191.1\|WP_015619877.1\|1963096_1964353_-\|glycoside-hydrolase-family-18-protein	gnl\|CDD\|119365	cd06548, GH18_chitinase, The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.	1.08778e-122
NC_021191.1\|WP_015619879.1\|1965192_1967058_-\|fluorothreonine-transaldolase	gnl\|CDD\|275299	TIGR04506, fluorothreonine_transaldolase, fluorothreonine transaldolase. Members of this family are fluorothreonine transaldolase, and enzyme involved in biosynthesis of 4-fluorothreonine, one of the few known known naturally occurring organofluorine compounds. [Cellular processes, Biosynthesis of natural products].	0
NC_021191.1\|WP_041833330.1\|1968381_1968885_-\|YbaK/prolyl-tRNA-synthetase-associated-domain-containing-protein	gnl\|CDD\|239828	cd04336, YeaK, YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, and ProX. The primary function of INS is to hydrolyze mischarged cysteinyl-tRNA(Pro)'s, thus helping ensure the fidelity of translation. Organisms whose ProRS lacks the INS domain express a single-domain INS homolog such as YbaK, ProX, or PrdX which supplies the function of INS in trans.	2.19522e-64
NC_021191.1\|WP_015619886.1\|1973139_1973682_+\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	1.41645e-61
NC_021191.1\|WP_084504065.1\|1971945_1972830_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.01367e-46
NC_021191.1\|WP_015619894.1\|1981916_1982978_-\|aldehyde-dehydrogenase	gnl\|CDD\|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	2.6563e-103
NC_021191.1\|WP_041832040.1\|1973844_1974741_+\|adenosyl-fluoride-synthase	gnl\|CDD\|275300	TIGR04507, fluorinase, adenosyl-fluoride synthase. Members of this family are fluorinase (adenosyl-fluoride synthase, EC 2.5.1.63), an enzyme involved in the first committed step in the biosynthesis of at least two different organofluorine compounds. Few organofluorine natural products are known. Related enzymes include chlorinases (EC 2.5.1.94) that lack fluorinase activity, although a fluorinase may show chlorinase activity. [Cellular processes, Biosynthesis of natural products].	0
NC_021191.1\|WP_041833334.1\|1976252_1977230_-\|carbohydrate-kinase-family-protein	gnl\|CDD\|238917	cd01942, ribokinase_group_A, Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.	4.52933e-68
NC_021191.1\|WP_015619878.1\|1964455_1965172_-\|hypothetical-protein	gnl\|CDD\|366857	pfam01909, NTP_transf_2, Nucleotidyltransferase domain. Members of this family belong to a large family of nucleotidyltransferases. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalyzing the addition of a nucleotidyl group onto the drug.	0.000673081
NC_021191.1\|WP_015619888.1\|1974809_1976183_+\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	1.98503e-33
NC_021191.1\|WP_015619891.1\|1978457_1979897_-\|adenosylhomocysteinase	gnl\|CDD\|377487	pfam05221, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.	0
NC_021191.1\|WP_015619875.1\|1961116_1962763_-\|sodium:solute-symporter	gnl\|CDD\|223664	COG0591, PutP, Na+/proline symporter [Amino acid transport and metabolism / General function prediction only].	1.17267e-58
NC_021191.1\|WP_015619893.1\|1980998_1981907_-\|pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|181319	PRK08246, PRK08246, serine/threonine dehydratase.	1.15701e-132
NC_021191.1\|WP_015619876.1\|1962767_1962974_-\|DUF3311-domain-containing-protein	gnl\|CDD\|371707	pfam11755, DUF3311, Protein of unknown function (DUF3311). This is a family of short bacterial proteins of unknown function.	0.000130237
NC_021191.1\|WP_015619890.1\|1977235_1978423_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NC_021191.1\|WP_015619892.1\|1980113_1980983_+\|S-methyl-5'-thioadenosine-phosphorylase	gnl\|CDD\|350161	cd09010, MTAP_SsMTAPII_like_MTIP, 5'-deoxy-5'-methylthioadenosine phosphorylases (MTAP) similar to Sulfolobus solfataricus MTAPII and Pseudomonas aeruginosa PAO1 5'-methylthioinosine phosphorylase (MTIP). MTAP catalyzes the reversible phosphorolysis of 5'-deoxy-5'-methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1-phosphate. This subfamily includes human MTAP which is highly specific for MTA, and Sulfolobus solfataricus MTAPII which accepts adenosine in addition to MTA. Two MTAPs have been isolated from S. solfataricus: SsMTAP1 and SsMTAPII, SsMTAP1 belongs to a different subfamily of the nucleoside phosphorylase-I (NP-I) family. This group also includes Pseudomonas aeruginosa PAO1 MTI phosphorylase (MTIP) which uses 5'-methylthioinosine (MTI) as a preferred substrate, and does not use MTA. NP-I family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.99742e-133

>NC_021191.1|WP_015619884.1|1970971_1971613_+|hypothetical-protein
MPTSSTVEEAVLRRGFHPHPRRGACLLELVSTLPGGPWTDRPRGVPPLLAVVCRSVNDRLSDAARSGILPAVPWLAALPAAAGRDPDALFGGLLEAAARWAGAAVWALPRDRPRARVLRRAVRQVAELPGADAALQQLLFDAIDVTRTGCGLPPVPWSSQPSVAGPGGTVGLRMRAETRCPDDSLSTYLWCGAELQQWPGALRQAWADARPAA
>NC_021191.1|WP_051167388.1|1970109_1970685_+|helix-turn-helix-domain-containing-protein
MGAAVGREIRRFREARRMSVSELARRADLSKGTLSRLEAGGGNPTIETIAAIAVALRLPLGDLIPTSTPAIPMLQRGTPDPDYSRQDLLQRIGPGVLTELWRVRIRQAGGLVDSPAHAAGTVEYLLVSRGVFRAGPVSALSELHAGDFLVYPADVPHRYEVVDGPGEASLMMTYPAMNVGVAGSPLHAETP
>NC_021191.1|WP_157408274.1|1969034_1970036_+|EamA-family-transporter
MRNPSGLSPELIDTPAGAPVALPPVPVTRDRSALLRSDLSILLVAIIWGSSYVVMQTVGDKVPAAAFLALRFLTALPVVLVLAAPSLRRLNKVEVLAGAAFGTMLYGILILETIGVQHTSAANAGFLITVSVVLVPLLERVLSGRAQPRIVYTATVFALLGCALLLLHDGIHPRSGDLIILAAAMIRATQITLFGRHVHGQSIQNLTAVEFVVVVLLATVTSVATGHPVWSVATHVDGRSWLLITYLGVLGTAFAFFMQLRSARLSSSTRVGLILCTEPVFATAFALLVAGETLGLLQAVGGLLMVGSALVGRAAESSGQETEDRAANPSGAG
>NC_021191.1|WP_041833330.1|1968381_1968885_-|YbaK/prolyl-tRNA-synthetase-associated-domain-containing-protein
MPYEETYDRLIALLDTNGASYRLIDHPEEGRTEIVSGYRGHEVASAAKCMIVMVKLGKKVTKYVLAVVPGDARVDLQAIKGLLGGTYISFANPEIAERLSGCVAGTILPFSFSDELELIADPGIKAFPELFFNAARLDRSMALRTEDYLRIAEPRFEPIAASNTTAG
>NC_021191.1|WP_015619880.1|1967253_1968255_+|S-methyl-5-thioribose-1-phosphate-isomerase
MRAIDWQDDAVVIIDQTLLPARAEFLVLRQPEQLVTQIQRLAVRGAMALGVAGAMGVALGAVRAREQGRDVLDAARAAAALVSRARPTAVNLAWGTARALASAPDGVDAVVATALSVRDADIAANRAIGARGAALLRGARRVLTHCNTGALASVEVGTALGVIGHLHRQDPLEMVFAAETRPLLQGARLTAWELGQARMPHRIVVDGAAAGLILSGAVDAVVVGADRIAVSGDTANKVGTVAHALAAARAGIPFVVAAPEATIAGDTPSGADIPIEERDEQEVLCVAGHRVAPPGARARNPAFDVTPADLITAIVTERRVIPLGRSDTGVSAA
>NC_021191.1|WP_015619879.1|1965192_1967058_-|fluorothreonine-transaldolase
MSMPQPIMTLNRVARLIEQEESESGTVLHLTANETLLSPAAQQVLSSPLVNRYLLEHLEMREDSPSRLNNFLYRGMNGINAIEASATEVCRQLFGAEYAEFRCLSGIHAMQTTFAALSQPGDKIMRISTKDGGHFLTELICRTFGRNSCTYAYRDISEIDLDRTREIFQRERPKLLFLDAMNYLFPFPVAELKEICGPVPLVYDASHTLGLIAGGQFQDPLGEGADILQANTHKTMFGPQKGIILGRSRGLMERISYTMSNGLVSSQHTASALALFIALHEMYTYGREYASRVVESSRYLASALHDRGVPIIAADRGFTRNHMFFVDNRPLGAGPALLERILRAGIAVNRSVAFEQTDTMRLGVQEVVRRGFTNADFDLIADWLAALLLRDADPEPIARGVKDLLATRTEIKYCEPTTAAAQQPAPETGHAPAGQLPARRWADIMLRREALDIDRPAYEGARYLGQLAGVFEHQTDSAGNISFQRDGSTFVTATGSYIKDLTPADFVELQDCTGTTLQCRGTGTPSAESYMHYLMRTTVDAAFVVHNHYIPDDDELGLIDVLVIPPKEYGSIPLAEAVAKAALQSQIIYVRRHGLVFWSASLEEGSEMLKKVTTALHAAHS
>NC_021191.1|WP_015619878.1|1964455_1965172_-|hypothetical-protein
MHDGPQRELIDKVRQACLEDPALDAALMYGSFAQGTADEHSDIEFWLFFARPQPDPAAWINRVSPARYVLLNEFGAHVAIFPGLIRGEFHFAGTADMAAVAAWPAAPVVPLVDRRAALPQPAAPIDMSADICGRFANWLLLAHHVGRRGETLRRRDALAHAQRHLLWMARLASGRTGHWLTPSRQAEAELDLALVARFDRTHEDVRAAWHLGRDLWHRLDPNPPRDLIEDLDRAIGRP
>NC_021191.1|WP_015619877.1|1963096_1964353_-|glycoside-hydrolase-family-18-protein
MRILPAVVAALIGVTAAAAPAEAHSKDRYVKVGYFTQWGIYGRDFQLAKVDKSGAASRLTHLNYAFGPVTAAGVCDSADPWADWQTPFSAALSVDGVADTADQPFAGNLHQLAELKRKHPGLRVLISLGGWSGSSYFSDAALTDASRKKLVSSCVDLWIKGNLPGLSAGVAQGIFDGVDLDWEWPGSDGDAGNVVRPEDKHNFTLLTAEFRKQLDALSRRTHKRYDLTAFLPAAPAKMDAGFEARRIFKYLDFGTVQGYDFHGSWETRTNQQSAIRVPAGAPDSPDFSLENAITAWRSRGAPSSQLVLGIPYYGQGWTGTSGLFQPATGGAPGTFAVGTEDYKVLKTLPAQGYTAHRDWRAGFSYLFDGTTFWTYDDPAQISQKTAWIRSQRLGGAMMWSLDGDDAQASLTRAVAAGL
>NC_021191.1|WP_015619876.1|1962767_1962974_-|DUF3311-domain-containing-protein
MTEPKPRSDRSPWNWLLVIPIALPLITPLFNADSPRLWGFPAFYWLQFAFILVGVATTSVVFQMTRKR
>NC_021191.1|WP_015619875.1|1961116_1962763_-|sodium:solute-symporter
MSDHITEIVVFTFLFLLVSAVGFVAARWRAPKDMAHLDEWGLGGRSFGGWITWFLVGGDLYTAYTFVAVPALIFGAGAAGFFAVPYTIIVYPIFFLVLIRLWSVSHRHGFVTPADFVRTRFGSPTLALLVAITGIVATMPYIALQLIGIEAVLKTMGVTGDSALARHLPIIIAFAILAAYTYQSGLRAPALIAFVKDTLIYIVIVVAVLYLPYKLGGWGSIFDDAQAKFQASPAPGDGITLNANNQLQYITLALGSALALFLYPHSITGVLASKNRNVIKRNMSALPAYSFLLGLIALLGYMAISAGVKPLPGAKAGSVDSNTVVPLLFDQQFPSWFAGVAFAAIGIGALVPAAIMSIAAANLFTRNIYKEYLRRDATPAQEAKVSKITSLLVKVGAVACIIFLDPQFSIDLQLIGGVIILQTAPSVALGLFTRWFHRGGLIAGWIAGMGLGMWMLYDIPNAATKRAHFGGSAFPLNDFGFDTPRTIYVGFVAVAVNLLVAVIVTLVLRAAKTPDGADGTTTDDYFADAGDPRLEQERTTPDAIGSST
>NC_021191.1|WP_084504065.1|1971945_1972830_-|response-regulator-transcription-factor
MIPSRPHQCRRPDCRSASQCRHHGGARHPERTRQLEKTRKYGELCVTYDHATYDNPTSDRAGMLDAGQHRTEPTSQRRYPSAVTSGTAGLITVALIDEPGLFREGLVGLLERQHGIRVVGALRPGPEAMQTLRRQLPDILLVSLDAANSNALDDLQLLRHAIPQAKLVILATRDDPRRVEHLLSSGAHAYIMKSASLDELLATIRVVDQHEDRVVLSVSRETMNRLRANSEPILSHREAEVLTLVAEGMRNSDIAGKLFIAEGTVKRHLTNIYAKLGATSRTDAVRRATKAGLA
>NC_021191.1|WP_015619886.1|1973139_1973682_+|adenine-phosphoribosyltransferase
MSSGTKIALASQVRVFPDFPHPGIAFQDLAPLYAAPGLITRLGAEVADSFSGEFDTVLAVEARGFVLGTAVAMAARCPLVLARKQGKLPGPLHSAEYSLEYGSAVLTVQHGAISPESTVLAVDDVLATGGTLAAAADLVNQAGGGLAGFAVLLELGALGGRDRLQPARVFSLLTSGEAPK
>NC_021191.1|WP_041832040.1|1973844_1974741_+|adenosyl-fluoride-synthase
MPANGNPIIAFMSDLGTTDDSVAQCKGLMLSICPGVTIVDVNHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTATRSVALRIKQAAQGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVIEEHGYIEAYEVSNTKVIPAEPEPTFYSREMVAIPSAHLAAGFPLNEVGRALSDDEIVRFAKPKPSTVSGGVLSGVITNIDHPFGNLWTNIHRTDLEKAGIGYQTQLRLLLDGVLTFDLPLVPTFADAGQIGDPVIYINSRGYLALARNAAPLAYPYNLKAGLTVTVTKA
>NC_021191.1|WP_015619888.1|1974809_1976183_+|cation:proton-antiporter
MSLSSQQIAALVAVIAIVVLMCHAIGGLFARYRQPVVVGEILAGLLFGPTVLGLVAPDFQHLLFPRTGPVAAILAGLAQLGMLLLMFVTGSELRLTASPGDRRTIGLVAATGMVVPFAVGLAVVAALDYHDLSGPAGTRTTTILVFAIAVAVTSIPVISRIMLDLGLLGSSFARVVLGVAALEDVGLYVVLAVVLSLASAPATEFGLWELVGVHTTGWTVGYHTTITIVFLGAFLMWGTPVFRFLLYGPARVLSRRNPAAARLVLLLIAVLVCTLLGINPIFGALLTGICARRAEPDRVPVEPGAPGLGQPDSWATIRHFSLAFFIPVYFFTVGLGLDLVHDFDVWFFVWFFLVCCVVKSLSVLAGALLSRQSLRWSLDLSIALNARGGPGIVLATTTLSAGVVNRSFYTAMVLLSVLTSQIAGMWLDRRSAALLGWDRDVAGGRTDARPVAIGEQH
>NC_021191.1|WP_041833334.1|1976252_1977230_-|carbohydrate-kinase-family-protein
MTTLVTGSIAVDHLSTFPGRFVDQIVPGSLASLSLSFLVDSLDVRRGGVAANIALGMARLGHRPAVLAAAGHDFDDYRSWLERAGVDVASIHQSADLHTARFQCITDRDGNQLASFYPGAMTQARRLELRPAVDRLGSVRHVVIGPNDPEAMLRHTDECRYRGYPFVADPSQQLAVMEPKDIRRLIEDAQYLFTNEYEHALVLQKTEWTHDEVLSRVGIWVTTLGARGARIEQDGHPVLDVPAVPVAEPVDPTGVGDAFRAGFLTGVAAGLGLVPAAQLGCALAALVLRVVGPQEYELDRTAFTTELATVYGDRAAADAATALHW
>NC_021191.1|WP_015619890.1|1977235_1978423_-|methionine-adenosyltransferase
MAYRLFTSESVTEGHPDKIADQVSDAVLDAFLAGDPDSRVAVETLITTGQIVIAGEVSSRAVVDVAAVARNQVVAIGYDSSAKGFDGRSCGVSVSIGAQSPDIARGVDESYEARSGEAGTDADRQGAGDQGLMFGYACTETPELMPLPIALAHRLARRLAQARRDGTLGYLRPDGKTQVTIAYEGNHPVALDTVVVSAQHAPDAENLLPDDIRKHVVEPELNRLDLATADYRLLVNPTGRFEIGGPMGDTGLTGRKIILDSYGGAARHGGGAYSGKDPSKVDRSAAYALRWVAKNVVAAGLAERCEVQVAYAIGKADPVGTFVECFGTEKVPVPRLAAAVAEVFDLRPRAIVEQLALLRPIYLPTAAYGHFGRSGPEFTWERLDRVDDLRTAVGG
>NC_021191.1|WP_015619891.1|1978457_1979897_-|adenosylhomocysteinase
MAFTDFKVADLGLAPLGRKEIQLAEHEMPGLMALRAEYSGAQPLQGARITGSLHMTIQTAVLIETLTALGATVRWASCNIFSTQDQAAAAVVAGPDGTPEDPRGVPVFAWKGETLEEYWDCTERALAWPGGTGPDMLLDDGGDATLLVHRGAEFEKLGAVPEPGSADSEEYAVILRLLDRCLRADPGRWTRVAEGIKGVTEETTTGVHRLYEMQQEGRLRFPAINVNDSVTKSKFDNRYGCRHSLIDGINRGTDVLIGGKVAVVNGYGDVGKGCAESLRGQGARVIVTEVDPICALQAAMDGYQVATMDDVVATADIFITATGCLGIISHEHMARMKHQAIVGNIGHFDNEIDMAGLARRPDVVRVPIKPQVDKWVFDDGHAVIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELFTKTADYPIGVYVLPKHLDEKVARLHLDALGARLTELTKEQAAYLGVPVEGPYKPDHYRY
>NC_021191.1|WP_015619892.1|1980113_1980983_+|S-methyl-5'-thioadenosine-phosphorylase
MVATVDRTPRIGVIGGSGLYDLELLEQVETIAVRTPYGQPSGDITVGNLLGVRIAFLPRHGTGHRLSPSEVPARANIHALRELGVRQIIAISAVGSLTERFAPGTLVVPDQLVDRTKGVRPATFFGGGAVAHVSMADPFCERLRADLGTAGKTAGYDLADGATYCCIEGPQFSTRAESHLYRSWGLDIIGMTAVPEAALAREAQLCYAGLALVTDYDCWHESEEAVTAGMVAETMRANVRAAREVLKEAVTTIDRTADCTCHHALTGAVLTDPAIIDAATRERCGLPVR
>NC_021191.1|WP_015619893.1|1980998_1981907_-|pyridoxal-phosphate-dependent-enzyme
MTTSTAIEAAAQRIAGRIRTTPVLDTGDVLYKLELVQHAGSFKTRGMFNKILTAAEHGLPAAGIIAASGGNAGLAAAYAAGELGTPAEIYVPATAPPVKVAKLAKLGARVTQVGAEYAEAFEAATARAQQTGAVFCHAYDDPDMVAGNGTLGLELLGQAEFDTVLVAVGGGGLVAGVAAALHGRKNVVAVEPETSRALHAALVAGHPVDVPVSGIAADSLGARRVGSIAYETATETKLTSLLVADEAIVAARHWLWDEFRLAVEHGTAAAQAALMSGAYVPQPGERVMVLLCGANTNPSDLG
>NC_021191.1|WP_015619894.1|1981916_1982978_-|aldehyde-dehydrogenase
MSVRIGINGFGRIGRSVMRIASGAADPQITVAAINDIAPPDRLAYALKRDSLRGRFTGTVDSRPGFLIVNGREVRSFQEPQPGRIPWAEADVDVVLEATGRFRSGDAARAHILGGGARKVVISASADQPDAFLVYGANHDRYDPARHDVISPASCGVNALSVMARVLLDRFGLHSVHTSVVLAIQGWQKPQDSIAGTSRDDLRLGRATTQSIIPHDHVTGDLVSVVLPRLGEICHSYYCVPTPIGSLAELGGRTERPVTAEEVNRAMSEAANGYLRGIIDYDPDPTVSIDVRDNPASCLFDPTGTRTTTDGRIKVRGWFDNEWGFSNRLLDLARLVGDRAPVPAGAERHPAVV

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_7

2251615-2251736

Orphan

Consensus_repeat	Method
GTGTGGGCCACTGGCACCAATCAGGCCGGCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_7

>merge|NC_021191|7|2251615-2251736|CRISPRCasFinder
GTGTGGGCCACTGGCACCAATCAGGCCGGCTCGACGCTGGAGATGCAGACCGACGGCAACCTGGTTGTCTATGCCCCGGGTCATGTGGCGGTGTGGGCCACTGGCACCAATCAGGCCGGCTC

>NC_021191|7|7|2251615-2251736|CRISPRCasFinder
GTGTGGGCCACTGGCACCAATCAGGCCGGCTC	GACGCTGGAGATGCAGACCGACGGCAACCTGGTTGTCTATGCCCCGGGTCATGTGGCG
GTGTGGGCCACTGGCACCAATCAGGCCGGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015620132.1\|2245007_2246147_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|379140
NC_021191.1\|WP_041832083.1\|2248465_2249080_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379883
NC_021191.1\|WP_041832084.1\|2258174_2258807_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380054
NC_021191.1\|WP_015620142.1\|2256228_2257524_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015620147.1\|2260361_2262533_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NC_021191.1\|WP_015620141.1\|2255247_2256123_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_021191.1\|WP_015620138.1\|2253099_2253513_+\|IS5-family-transposase	unknown	unknown	gnl\|CDD\|379129
NC_021191.1\|WP_015620130.1\|2243507_2244116_-\|30S-ribosomal-protein-S4	unknown	unknown	gnl\|CDD\|235411
NC_021191.1\|WP_015620136.1\|2249658_2250501_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_021191.1\|WP_015620131.1\|2244226_2244967_+\|DUF2470-domain-containing-protein	unknown	unknown	gnl\|CDD\|378456
NC_021191.1\|WP_015620128.1\|2239904_2241692_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_021191.1\|WP_051167748.1\|2241724_2243470_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_021191.1\|WP_084504070.1\|2246837_2247359_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176864
NC_021191.1\|WP_015620139.1\|2253729_2254131_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379275
NC_021191.1\|WP_015620140.1\|2254127_2255126_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NC_021191.1\|WP_015620145.1\|2258815_2259541_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|272861
NC_021191.1\|WP_041832082.1\|2246172_2246778_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NC_021191.1\|WP_084504072.1\|2257535_2258105_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238008
NC_021191.1\|WP_015620134.1\|2247327_2248374_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381317
NC_021191.1\|WP_015620146.1\|2259537_2260254_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015620132.1\|2245007_2246147_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|379140	pfam13360, PQQ_2, PQQ-like domain. This domain contains several repeats of the PQQ repeat.	1.0727e-14
NC_021191.1\|WP_041832083.1\|2248465_2249080_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	4.34722e-19
NC_021191.1\|WP_041832084.1\|2258174_2258807_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380054	pfam17920, TetR_C_16, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	8.80928e-33
NC_021191.1\|WP_015620147.1\|2260361_2262533_-\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	2.84497e-09
NC_021191.1\|WP_015620141.1\|2255247_2256123_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.68567e-32
NC_021191.1\|WP_015620138.1\|2253099_2253513_+\|IS5-family-transposase	gnl\|CDD\|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	2.27803e-18
NC_021191.1\|WP_015620130.1\|2243507_2244116_-\|30S-ribosomal-protein-S4	gnl\|CDD\|235411	PRK05327, rpsD, 30S ribosomal protein S4; Validated.	4.90682e-93
NC_021191.1\|WP_015620136.1\|2249658_2250501_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	4.8904e-07
NC_021191.1\|WP_015620131.1\|2244226_2244967_+\|DUF2470-domain-containing-protein	gnl\|CDD\|378456	pfam10615, DUF2470, Protein of unknown function (DUF2470). This family is a putative haem-iron utilisation family, as many members are annotated as being pyridoxamine 5'-phosphate oxidase-related, FMN-binding; however this could not be confirmed.	0.00357236
NC_021191.1\|WP_015620128.1\|2239904_2241692_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.8297e-129
NC_021191.1\|WP_051167748.1\|2241724_2243470_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.67473e-139
NC_021191.1\|WP_084504070.1\|2246837_2247359_+\|hypothetical-protein	gnl\|CDD\|176864	cd07822, SRPBCC_4, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	2.56737e-20
NC_021191.1\|WP_015620139.1\|2253729_2254131_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379275	pfam13577, SnoaL_4, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	2.63086e-15
NC_021191.1\|WP_015620140.1\|2254127_2255126_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.35502e-124
NC_021191.1\|WP_015620145.1\|2258815_2259541_-\|ABC-transporter-permease	gnl\|CDD\|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	6.86854e-29
NC_021191.1\|WP_041832082.1\|2246172_2246778_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	2.12062e-10
NC_021191.1\|WP_084504072.1\|2257535_2258105_-\|hypothetical-protein	gnl\|CDD\|238008	cd00051, EFh, EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.	1.30054e-09
NC_021191.1\|WP_015620134.1\|2247327_2248374_-\|aldo/keto-reductase	gnl\|CDD\|381317	cd19091, AKR_PsAKR, Polaromonas Sp. aldo-keto reductase and similar proteins. The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.	0
NC_021191.1\|WP_015620146.1\|2259537_2260254_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.19145e-72

>NC_021191.1|WP_015620136.1|2249658_2250501_+|CPBP-family-intramembrane-metalloprotease
MSLRVRAILVYLAIAFGGVWPYLFFVRLSLGWSLINPLVQLPVAFMPAIGAFVVRRWVTREGFVDAGLRLRFRRAWRHWLVAWLMPLGVTALALAGAATAGWWNGDLSPAGGPGGIFLLLMLQVVLTPAYMGEEFGWTSFLWPRLIPGRPRRSVAATGFIWAVWHYPLAYLGYAEFSDHTVSMAVWTIQFMLFEVMLCWLYAKTGSVWATSLAHAGNNMVQGVLTEQLLINGGHLDALRVIICVDLALSLVCIPLVRSKAFTAAPGKAIGLPAADQPTLG
>NC_021191.1|WP_041832083.1|2248465_2249080_+|TetR/AcrR-family-transcriptional-regulator
MPVGATRPGGRTARVRAAVLRAAGDALVDHGLDRLDLADVARRAEVGKTTVYRRWGTVTGLVADLLADMAEQSLPRTDNGSLIEDLRANARLVQRTLADPRQGPLFRAVIVAATCDSRAAEALHHFYAVRIAEWTPCVEQAIRRGELPPATDAAEVIRAVSAPLYYRLLVTGDPIDIATADRAAEAAAAAARAGVYASSVGDVP
>NC_021191.1|WP_015620134.1|2247327_2248374_-|aldo/keto-reductase
MEHRRLGASGLTVPVLSFGAGTFGGSGPLFGAWGSTDAREARRLVDICLDAGITMFDTADVYSDGASEEVLGQAVKGRRDDVLISTKSGLPTGDGPNDAGTSRARLIRSVEAALRRLGTDYIDLFQLHAFDAATPVEEVVATLDDLVRAGKIRYPGVSNFAGWQLMKSLAAADRDHRTRYVAHQVYYSLVGRDYEWELLPLGLDQGVGAMVWSPLGWGRLTGRIRRDTPPPPTSRLHETATFGPPVDDDHLFGIVDVLEELSRETGRAVPQIAINWLLRRPTVATVIIGARNEAQLRQNIDAAGWSLTPEQMARLDAASTRTAPYPYFPYQRQEGFARLNPSPVATTG
>NC_021191.1|WP_084504070.1|2246837_2247359_+|hypothetical-protein
MEEPMDTVDDWPAGFDPRTAPVHARNEIRTSLAAEQLWPALITATTWPQWYPGAQQVTISGGGAALTATSHFTWKTLGVRVKTQVTEFEPARRLAWRGTGPGAAGYHRWILTPTADGGCVVLTEEVQTGLVARLRADRLRRSLLANHQQWIEGLVEVSQPGSALSRWSRPATG
>NC_021191.1|WP_041832082.1|2246172_2246778_-|TetR/AcrR-family-transcriptional-regulator
MSEKRRLVNPRGQGGRLRQEILDAAVVLLGRAASDDGVTLRDIARQAGIAAPSIYSHFADRAAVIDAVVTESFAELKAVAHAAGDGVDHPADRLRALCAAYVRFGREQPGRYRILFEASQREAAKRQPAANGDAAFAGLTAALADCVTDGSSAATDPALDATALWVALHGLVVLPRATPAFDWPATEVLLDRIITSLAHLR
>NC_021191.1|WP_015620132.1|2245007_2246147_+|PQQ-binding-like-beta-propeller-repeat-protein
MINGVTRRGLLTGTAGLLALAGCGSDTGKTTGREVRWRHDFAAEPVHPTAAANVVVAGDRVLVSHKGRLLGYAAATGDPAWETNQGTLRLFNAHPPIVDGNTLLMLTDATLKGELRAFQPATGSMRWKYGGYQDSIGMHLNWPAAAGGVACYSGLGYLGAVDIRTGRELWTKKARTQFPEPFGEPVMTPDTIWLPSAAGSITAWAARTGKNRWVAGDVTAGAGETRLGLGGGTVVSRSGGTVIARAADTGKKRWSATEDGAGSGGQHPIVTADAVLLTDNVGTTGTNAVVALSLADGTSRWKFPTETRITGDITAAGGSVYVPTEGALHALDPATGRPRWTLRSGKALFSNAAVSSDLVHVLAMSPDEDVQDSLLAIPR
>NC_021191.1|WP_015620131.1|2244226_2244967_+|DUF2470-domain-containing-protein
MQPTHAELARTLAAGHLPATAHIAGRPGPYPVRHVTDARGRVLLLSPRDGAVAAALRPGPDTGDTALVLDIADVPPVAGAPSLGRVRVAGWATPLQGAEARQAALDYADTDPATDLLDVGDTQVIHRMDVAEIRYERAGVPADVDPDEYAEATPDPLHRIEFDLIADLAGHHVTAMAGYVRRRLGPAARPGDDPRMVRLDRYGFVVRLGDRLARLSFPRPVTDRHDLAHLLHPILCHRCGHQERAA
>NC_021191.1|WP_015620130.1|2243507_2244116_-|30S-ribosomal-protein-S4
MNNSRPKARLSRALGIPLTRKCVKYFERRPFPPGVHGRGRRKQSDYQVRLLEKQRLRHQYNISEAQMRAAYDEAHRKEGKTGENLVAHLESRLDATVQRAGLARTIYQARQLVAHGHFTVDGKKVDRPSYRLKPGQVVEVRESSRQKPPFQVAAAGAHLDGPTAPYLSTVIEDLRTTVIRKPLRSEVPVICDEQLVVEFYAR
>NC_021191.1|WP_051167748.1|2241724_2243470_+|ABC-transporter-ATP-binding-protein
MLATVRRGVALSPELRPGLAGTLALAFVSMAGRVAVPIAIQQGIDRGIQAPGGPDLGVIGFIVGLTLVVLAISTTCGYWMTRRLFTVSETALGALRARTFRHVHDLSMLHQQSERRGSLVSRVTGDVDQISQFLQTGGVTLLMSVGQVVVTTIVMLVYSWQLTLVVFLAFVPAVIVIRLFQKRLAAVYRVVRERTGVLLGAVAESVVGALVIRAYGVAARTEKRLDTSIDQLRVAQQRALRTSVTSFSTGELAAGLALAAVVVVGVLLGVDGGLSVGKLTAFLFLVTLFIQPVQIATEVLNDAQNAVAGWRRVLDVLDIRPDVADPDLDGVALPPGPLSVRFADVSYRYPGGPIVLSDVDLEIPARTKVAVVGETGSGKTTFAKLLTRLMDPAGGEVLLGGTPLTTVRFDSLRSRVVMVPQDGFLFDATVAENIRFARPALTDDDLELAFQELGLADWLAGLPQRLETPVGERGEALSVGERQLVALVRAYVADPDLLVLDEATSAVDPATEVRLQHALDAVTRGRTTVAIAHRLSTAAAADEVIVVDAGKVVQRGPHAVLVAQEGSIYASLYASWLEQTR
>NC_021191.1|WP_015620128.1|2239904_2241692_+|ABC-transporter-ATP-binding-protein
MTTRASQDVLGRGLCVLGRAIRTEPRLFTAGVVGSSLFGLLIIANSYVVGAVIGRVVVPAFAEHRAGAGELALIAATFIGISLLRVASIFGRRLGAGYMQFRLQARYRSAVTRRYLALPPSWHQRHATGTLLSNANSDVEAAFVPIAPLPFAVGTVVMILAAVISLFVTDWVLAMVGVCLFPALFGLNYIYSRRMSPRQIRAQQLRARVSAVAHESFDGALVVKTMGREADESQRFRVHVSELRDALISVGRLRGLFDPLMDALPSIGTLAVLLLGAWRLQSGAISVAQLVSVAFLFTVLAFPVRAIGWVVAELPRSVAGWERVQAVLGAGGDLAYGSSATPGTGPAALTFDQVHYSYGNHADVLHDVSFTVPAGKTVALVGATGSGKSTIASLAVRLVDPESGTVCANGVPLPQLSGAALAATTALVPQVPFVFDDTVRGNVTLDRDGVDDEAAWHALRLAQADGFVAKLPAGLDTPVGERGTSLSGGQRQRLTLARALAGRPRLLVLDDATSAVDPRVEAAILASLRGHDAGASILVVAYRRATIALADEVVYLEDGKVVATGTHTELMSAEPGYLALVTAYEKNEQAEEVQA
>NC_021191.1|WP_015620138.1|2253099_2253513_+|IS5-family-transposase
MHPFRDIVDAILWIDRSGCSWRQLPVDFAPWQTVYGWFKRWKERGVTERILAGLREQVRLAEGCDTEPSAGVIDSQLVRAADTVGRDTRGFDAGKRVNGRKRFIVIETLGLLVSVRVLAASWQPRRGQDRDALRPGP
>NC_021191.1|WP_015620139.1|2253729_2254131_-|nuclear-transport-factor-2-family-protein
MIAELQHAVANYAHALDELDVPALEAILTQDTTWTFTVPGQGVLGPVAGREAVLDFVRAGHAAQTGRVRHHLSNVVVTTADTDSAHVRAYLAQTRNNGDDVQVISTGVYTFGLRRSATEWQIAELTLALDNAL
>NC_021191.1|WP_015620140.1|2254127_2255126_-|NADP-dependent-oxidoreductase
MKAIQFHQAGGPEVLQYDEVPVPEIGPGEVLVRVYAAGINPPDWYLREGLKVMPAEMRPPLEFPLTPGTDLSGVVQAVAADVAEFAVGDEVFGMVRFPGFDGRTYAEYVAAPASDLAHKPARLDHVHAAGAPMAVLTAWQLLIDLGHDVPSPFTGQVHQPVPITPGMTVLVNGAAGGVGHFAVQLAKWKGARVVAVASGRHEQFLRKLSADEFIDYTRTRAADVVSGVDLVIDTVGGPDSSRLLTVLKRGGTMLPVFFAQYDPEETARLGISVSNIQVRSDGPQLAEIGRLFDEGTLQVGVDSTYPLSEADKAHTRAAQGHIQGKIVLTVAS
>NC_021191.1|WP_015620141.1|2255247_2256123_+|LysR-family-transcriptional-regulator
MNDLGQDLELRLVRYFTAVAAHQHFGRAAADLRVAQPALSRQIQRLEKQLGARLLDRAPQGTRLTPAGQAFLPRAQALLQAARQAELAVREHAATERITVGYVEDLVITAAVQELRRRHPRAEITTRHLSCRDVGVLSDKGVDALIGRAPLPLAADQVLTTPLYEEPRMLVVPRDHPLAGRASVTSAELAGEKAAPCAFETTDWTSYQLLGAGVPPLESYEDKLELVASGRAIAVLPVGDLRSSLRPDLVTVPIEGAPPSRVVVVSRTGDPNPMIRSFRLAAKAVLTPSAA
>NC_021191.1|WP_015620142.1|2256228_2257524_-|hypothetical-protein
MADEAALALLDRIYANENALIDTAGRFAHHVPATIPAEDLRALAERRLTPNSFRDVEHDEAVTTLRRLAAAADERTAADAFVASLGPARLLRWRALLPAVALGTAMPAHPFPADAGARICDVCFLERTTTVDTTLAWWHRARHGSPLPGDVCHYILALEAAARPWPTPTPADVWTLHEILDVIRSLPPATRAGRAARALRERGLLGSRSPQAYQALVEDLAFLGILQTPDHPGMLTAFTTARRRDDRPGVRVEASAPLSFWSAAHGVTESLVDRLFGHLARPPERPHPPAQATPRRTSAVGKRAAPLPSALRGEARAGDVYAVQCREDAWILAFCHELQDRNGRRYGLVEYLDGLFPCPPTADDIDHRGFRGRPENRWQQWTSHLDKTPRVRRIARDVPTPPDDRPPPDRVSLGNAKDLRHLAGWCFPELA
>NC_021191.1|WP_084504072.1|2257535_2258105_-|hypothetical-protein
MRRARHMTDGTDDPIAVKLGHLFGASDTDGDGFVDWSDYERLISRYLDGYGIAAEDRRAHALRAAYQQYWSELLQQVNGTDRLSEEQFVAANQAAGVDRSRFTMAGLVPQAIFDVMDTDGDDTISKPEYKVFLEAWGVSDLEALNVFLELDTDDDGRISRDEFIGAIRDFFTSPELESPASLFFGHIER
>NC_021191.1|WP_041832084.1|2258174_2258807_-|TetR/AcrR-family-transcriptional-regulator
MVRRSGRRPGNQDTKQAILAAARTVFADRGFDKASIRAIATQAEVDPALVHHYFGTKEKLFLACMDLPINPAELIPQAIEGPRESAGERLVRLVLSVWDSPHGSVAVAMLRSAMSNEWTARLMREFVVTQILRRAIAGLGIDAKEAPMRTALVATQIAGMAVVRYVLKVEPVASAPAEHLVAAVGPSVQRYLTGDLPDVFATWPDEPGGG
>NC_021191.1|WP_015620145.1|2258815_2259541_-|ABC-transporter-permease
MILLATTARILRQLRHDRRTVALLVVVPTALLTLIYFMYDGTRAYDRVALVMLGVFPFVTMFLVTSIAMLRERTSGTLERLLTTPLGKLDLLFGYGLAFGLTAAAQAGVAVAAAYGLLGLDTAGSVGLVMLIAVVNAVLGVALGLLCSAFARTEFQAVQFLPVVVIPQLLLCGLFVPRAGMAGWLQAVSDVFPLSYAVDALAQVGAHAEATGTMWWDLTVVAGAAILALVLAAATLRRRTP
>NC_021191.1|WP_015620146.1|2259537_2260254_-|ABC-transporter-ATP-binding-protein
MNGAIEVKDLVVERGKRRVLHGISCSVPAGCVTGLLGPSGSGKTTLIRAVVGAQIVRSGSVTVLGQPAGATALRRTVGYVTQSPSIYGDLTVRENARYFAALHGLGAADAERAIADVGLKDAAGQLVGDLSGGQRSRASLACAMIGDPRLLVLDEPTVGQDPVLRAELWEKFHALAATGTTLLVSSHVMDEASRCDRLLLIREGRLIGDDSPAAIRAAAGTDDLEEAFLRLIKGVAVR
>NC_021191.1|WP_015620147.1|2260361_2262533_-|hypothetical-protein
MPEPRFTPEPYATPEPRLTPEPYATPQPHATPEPRVTPEPRATPQPRATPEPRATPEPWVAPEPDGRSAAAGDAGRSGAARADSDTEMVALGSRRPMDDLLSEPPTAPHQDDQEGVSPVETNGHRINGHRDGEPGPRHAGPNGQPRAAHNPLSMSRSPFAPPPPETPPLYAPSPFAAIPGNPPVPDLPEQPEDDVDQHPDPINGSAQVPPGPWAAPPVVPAHEDDVPPGPRPTYYAGNPFVTPPPAHPPAAPMTGDQRGSAPGQPGSAPGQPGSATGQPSSATGQPSSDTGRPSSDTGRAGGIEPVSYPQGRGLPPIVAETQPVNRADESTSVGSAAVVPGFRPAEPRPVETDPVQPSWSTPDHPGTTRDQTAADLPLGTHRPAATPEATPPGATPEATRPAATPGTTRPGADPERDQALRGAPTAPGRPDLLTTMDGPDLLTTTSGPDLLTTTGGADLLTTGGPASARPAPGEQRGTTGGVAAGPASARPAPVDQLGGIGATAGGSAPVAEPLADLPTVPQPARAAEAEVAAPWVPTGDDPSFQAAWESSGTQARVRQADPLPPNPLHPAPVVATPASSGGGRRRRNDDDELTGARATGTDESTGEADAVENSEPAVTPVAAAAQLRPGDVGETAISFWDETASGQFRAEWHEVKAQFVDDPVGALELARELVSQAVQELSTAMLAERDALDPLKDTAAPDTESMRIAMRAYTEFLERILSL

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_8

3746067-3746139

Orphan

Consensus_repeat	Method
GAGGGACTGTCATGACCGACCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_8

>merge|NC_021191|8|3746067-3746139|CRISPRCasFinder
GAGGGACTGTCATGACCGACCTGTCGGTTCTCGCTCCCGGACTCATCGCAGAAGGACTGTCATGACCGACCTG

>NC_021191|8|8|3746067-3746139|CRISPRCasFinder
GAGGGACTGTCATGACCGACCTG	TCGGTTCTCGCTCCCGGACTCATCGCA
GAAGGACTGTCATGACCGACCTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015621224.1\|3755794_3757588_-\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|276938
NC_021191.1\|WP_015621204.1\|3734987_3736055_+\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NC_021191.1\|WP_015621210.1\|3742425_3743484_-\|glucose-1-phosphate-thymidylyltransferase	unknown	unknown	gnl\|CDD\|273500
NC_021191.1\|WP_084504148.1\|3739093_3739909_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NC_021191.1\|WP_015621220.1\|3753341_3754055_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187654
NC_021191.1\|WP_063643202.1\|3755292_3755787_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|379275
NC_021191.1\|WP_015621213.1\|3744190_3744349_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015621217.1\|3749104_3751588_+\|sensor-histidine-kinase-KdpD	unknown	unknown	gnl\|CDD\|225115
NC_021191.1\|WP_015621206.1\|3737141_3737831_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_021191.1\|WP_015621219.1\|3752488_3753292_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297
NC_021191.1\|WP_041833620.1\|3754135_3754570_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NC_021191.1\|WP_015621205.1\|3736151_3737141_+\|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|224013
NC_021191.1\|WP_015621207.1\|3737827_3738991_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_021191.1\|WP_015621218.1\|3751584_3752262_+\|response-regulator	unknown	unknown	gnl\|CDD\|182522
NC_021191.1\|WP_015621222.1\|3754667_3755177_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015621225.1\|3757698_3759174_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341286
NC_021191.1\|WP_015621212.1\|3743480_3744035_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NC_021191.1\|WP_015621216.1\|3748232_3749099_+\|potassium-transporting-ATPase-subunit-C	unknown	unknown	gnl\|CDD\|376890
NC_021191.1\|WP_015621209.1\|3739911_3742404_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226957
NC_021191.1\|WP_041832248.1\|3744345_3744435_+\|K(+)-transporting-ATPase-subunit-F	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015621204.1\|3734987_3736055_+\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	5.19002e-82
NC_021191.1\|WP_015621210.1\|3742425_3743484_-\|glucose-1-phosphate-thymidylyltransferase	gnl\|CDD\|273500	TIGR01208, rmlA_long, glucose-1-phosphate thymidylylransferase, long form. The family of known and putative glucose-1-phosphate thymidyltransferase (also called dTDP-glucose synthase) shows a deep split into a short form (see TIGR01207) and a long form described by this model. The homotetrameric short form is found in numerous bacterial species that incorporate dTDP-L-rhamnose, which it helps synthesize, into the cell wall. It is subject to feedback inhibition. This form, in contrast, is found in many species for which it serves as a sugar-activating enzyme for antibiotic biosynthesis and or other, unknown pathways, and in which dTDP-L-rhamnose is not necessarily produced. Alternate name: dTDP-D-glucose synthase.	2.75984e-127
NC_021191.1\|WP_084504148.1\|3739093_3739909_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	4.84653e-105
NC_021191.1\|WP_041833620.1\|3754135_3754570_+\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	8.72494e-18
NC_021191.1\|WP_063643202.1\|3755292_3755787_+\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|379275	pfam13577, SnoaL_4, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	5.98532e-22
NC_021191.1\|WP_015621209.1\|3739911_3742404_+\|ABC-transporter-permease	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	8.25466e-21
NC_021191.1\|WP_015621217.1\|3749104_3751588_+\|sensor-histidine-kinase-KdpD	gnl\|CDD\|225115	COG2205, KdpD, Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms].	0
NC_021191.1\|WP_015621206.1\|3737141_3737831_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.61963e-64
NC_021191.1\|WP_015621219.1\|3752488_3753292_-\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	9.72317e-111
NC_021191.1\|WP_015621224.1\|3755794_3757588_-\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	4.36967e-31
NC_021191.1\|WP_015621205.1\|3736151_3737141_+\|dTDP-glucose-4,6-dehydratase	gnl\|CDD\|224013	COG1088, RfbB, dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane].	1.51226e-174
NC_021191.1\|WP_015621207.1\|3737827_3738991_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.11434e-28
NC_021191.1\|WP_015621218.1\|3751584_3752262_+\|response-regulator	gnl\|CDD\|182522	PRK10529, PRK10529, DNA-binding transcriptional activator KdpE; Provisional.	2.23595e-80
NC_021191.1\|WP_015621225.1\|3757698_3759174_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341286	cd17631, FACL_FadD13-like, fatty acyl-CoA synthetase, including FadD13. This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.	0
NC_021191.1\|WP_015621212.1\|3743480_3744035_-\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	5.04576e-16
NC_021191.1\|WP_015621216.1\|3748232_3749099_+\|potassium-transporting-ATPase-subunit-C	gnl\|CDD\|376890	pfam02669, KdpC, K+-transporting ATPase, c chain. This family consists of K+-transporting ATPase, c chain, KdpC. KdpC forms strong interactions with the KdpA subunit, serving to assemble and stabilize the Kdp complex. It has been suggested that KdpC could be one of the connecting links between the energy providing subunit KdpB and the K+-transporting subunit KdpA. The K+ transport system actively transports K+ ions via ATP hydrolysis.	5.77953e-40
NC_021191.1\|WP_015621220.1\|3753341_3754055_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187654	cd08951, DR_C-13_KR_SDR_c_like, daunorubicin C-13 ketoreductase (KR), classical (c)-like SDRs. Daunorubicin is a clinically important therapeutic compound used in some cancer treatments. Daunorubicin C-13 ketoreductase is member of the classical SDR family with a canonical glycine-rich NAD(P)-binding motif, but lacking a complete match to the active site tetrad characteristic of this group. The critical Tyr, plus the Lys and upstream Asn are present, but the catalytic Ser is replaced, generally by Gln. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type KRs have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	7.42533e-108

>NC_021191.1|WP_041832248.1|3744345_3744435_+|K(+)-transporting-ATPase-subunit-F
MSAVNLIGLVVAVLLGVFMVAALLFPEKF
>NC_021191.1|WP_015621213.1|3744190_3744349_+|hypothetical-protein
MNSDDSGFCARCAGAARSEPFLGVLVADVVFVLLTVVLFGALTVLVRAVERS
>NC_021191.1|WP_015621212.1|3743480_3744035_-|NUDIX-hydrolase
MAFLPPEIYYRTVATHFAAAEALIEDPAGRVLLVKATYRPDWTLPGGMVDDGEDPRTACAREAAEELSVAVTPGRLLAVDWVPAEGHRPRPLSVYVFDGGVLDAGAGVTLPPDELEGYRFTTAGHAGTVMTAANHARLQAARAARHGGTARYCVRGQPQLDQSSSASPEHGSSASAARFRRGIR
>NC_021191.1|WP_015621210.1|3742425_3743484_-|glucose-1-phosphate-thymidylyltransferase
MKGLILAGGRGTRLRPLSNTVAKQLIPVANRPILFYSLDTMREAGITQVGVVVGDHRAAIQDAVGDGSGFGLRVTYIEQSAPRGLAHAVNEARDFLGDDDFLMQLGDTVLLDSVLPLVEQFRAGRPAAALLLAKVSDPHEFGIAELGPDGAILSLVEKPRHPASDLAIVGVYAFTATIHQAVRAIGPSRRGEYEITDAVRWLLSTGHAVESRVTTGYWSDAGRLDDLLECNRVLLGRIEGGIHGRVDEASTLIGPVLVEEDACVTRSRIVGPAVIGLGSRVTDSVVGPHSSIGPGCEVVDSEVEASMLFDGAAVRGVRTLRHSLVGRRSQVQAQEGAHRVVVGDHDAVWISG
>NC_021191.1|WP_015621209.1|3739911_3742404_+|ABC-transporter-permease
MWRAVLANVRANWVRLLLTFTTVLIGATFVSSSVIFAESLARGRAALPADLGVLVTPPDQDPRSGATLDEATRLRLAELPGVTGAAGVVEGYAAAVGTDGKVALPRGFDVKMTGTNWGGTDRLRLDAGRAPTGGTEVALASRVADAGGVDLGDTVQVLYANGSVRAVVTGLYTYTGTGRESGAAPGVAFDTATAQRLLLAPGRYDAVELAVRGDPRQVAEAAAAVLPKGFTAVDRAQLDHELAEEERTLTASVQGTALTFAVISLIVGSTLITNTFAMLVARRSRELALLRAVGATRRQTRRWVLAEAAIIGIAGSVAGFVAGLGLAFPASAYAASFDPTLDGSVTVSWPAPVLTIAAGVLVTILSAWLPARRTARIPPAAALRVAPAEAAHTSRWRRRLGRLLFVPAVLALLGGSAGNNDGFGFLGMLGAVLLLPAVLLLVPAISGPAVRLLHRPTRRRASLSLAVQNIRRFPRRTSATASALLLGVALTTGIGIFASSITDQALVDMTGVLGDDIVIENVSGGPVGAASVSRVAAVSGVGATTTLRDADIAVDGEPARVSSVDPAAIGVTLHLDLGGAQPEQLIDGAFITKETADDRGWKTGQELAVATPDGGTQPVRIAAVLADAPLLGDVLMGPQLAERFLPADSERNALLVAVAAGSDRGAVQNAVRSAVADRPDLRLVTPEGYVRGLITEVDAFLGVAGGLLGLSLLIAFLGIINTLTLSVTERLREIGLLRAVGMSRGQVRAMVCAESLILAALGGLLGLITGGIFGAMAQHLVLTRPVFDLTIPVNSVVLSLAGLVAGGLIAALWPAQRAARANILEAVAPE
>NC_021191.1|WP_084504148.1|3739093_3739909_+|ABC-transporter-ATP-binding-protein
MTRRRRDRSSVGTVSKTSVTATTSAVAAHQLTKVYGTDTARVVALDAVDVQIPDGRLVAVMGPSGSGKSTLMHCLAGLDTPTSGQVMLGDVELSRLNDNQLTRLRRDRIGFVFQAFNLVPALTARENILLPLRIAGRRPDERRLAELAAAVGLENRLDHRPDQLSGGQQQRLACARALITDPRVVFADEPTGNLDSQSSAEVMGLLRRAVDQLGQTVVLVTHDPVAAGYADLVLFLADGRLVGELPEPTAELVLARMQRLSGIRPTGRERG
>NC_021191.1|WP_015621207.1|3737827_3738991_-|two-component-sensor-histidine-kinase
MDKPAAWPPWIEPLWRHRARVVDAFVAVVCAVTAAGPAMESTLFGGSPYFPGHSQRWVYFPVALVVGVLAFQRRRWPLAFVAGALAGWAVAAAYPAIVAAQYALGAYERSRRAVAGAIVVVLVAVGIPFAREGLDSIIPLSVAVCLAPALLGLWVGSRRLLLRSLRDRIRRAEWERQLVADQARAEERARIAHDMHDVVAHKVSLMVLHATALETQNVALAGRIRMIGRETLDELRTLVGVLRTDEAAPLTPQPTMADLDTLVQRSVEAGTPVTVESLGQTRQVPAIIEQIGYRVVQEALTNVHKHASSATTTIRVRYGPDRLHLTITNRRPSARPAAAAALPSGGHGLFGLRERVQLVGGRLTAQPTLDGGFEVDAVLPVPAREAE
>NC_021191.1|WP_015621206.1|3737141_3737831_-|response-regulator-transcription-factor
MISILVVDDEWMVRAMLRTILGSAADLTVVGEAADGAEAVAQAQKLRPDVVLIDIRMPGRDGLSATLDLVRLPMAPKVIILTTFDLDEYVRTGLRNGAVGFLLKDASADEMIAAVRAAAAGDAMLSPRVTRRLLETFADAPEQPPGTDRQAAARDRLSPLSDKELEVLRTLADGMANADIARHLHLSEATVKTHVSRILAKLKLTNRVQAAILAHHAGLTPGLLGDDLD
>NC_021191.1|WP_015621205.1|3736151_3737141_+|dTDP-glucose-4,6-dehydratase
MLVTGGAGFIGANFVQHTVRHHPEYEVTVLDVLTYAGDRAALDPVARDITFVHGDICDADLVDRLVGSTDVVVHFAAESHVDNSLNDPFPFVRTNVIGTFTLLEAVRRHGARLHHISTDEVFGELPLDRPDRFTEDTPYHPSSPYSATKAGSDMLVRAWRRSYGVAATISNCANNYGPYQHVEKFLPRQITNVMTGARPQLYGTGVNVREWTHVDDHNAAVHAILARGRIGETYLIGSGVECTNLQLVRLVLELSGQPDDAYDLVPDRSGHDLRYANDTTKIRTELGWRPVHDDIRDGLAATIAWYRDNRDWWLPHKAATELNYRTVKS
>NC_021191.1|WP_015621204.1|3734987_3736055_+|PQQ-dependent-sugar-dehydrogenase
MRASRRLAALVAMIGILGVPGTARAATAGAGAADPTIRTVTAYLTIPWGIGLLPDGSAVITERHTGRILLLRDGVTTEIQRIPLPSLDPEGGVQYEGGLLGLAVSPHYRFDRTIFIYYSTATDNRVAKLRLGGTPKPIVTGIPHAPQHDGGRLQFGPDGYLYVATGFGPDNDNSQNLSSLGGKILRITPDGKPAPGNPFGTLVYSYGHRNVEGMAWDSHGRMYASEMGDAAADELNRIYPGRNYGWPVCEGTCDDPRYVNPLLTWETSDASPSGLAFYHGNLYMAALHGQRLWQIPVRRDGGVEAPTALLAGTYGRLRTVLTGPDGSLWVSTSNHDLPFAHPAPDDDKILSITFR
>NC_021191.1|WP_015621216.1|3748232_3749099_+|potassium-transporting-ATPase-subunit-C
MRLPSWLSQHLAALRALLVLTVVTGLAYPLFLVAVGRLPGLDGKAGGSLVTVDGKRVGSSLIGQSFTDADGNADPRYFQSRPSAAGDGYDPTATSAGNLGPESVVDTLADNPGDASQSLLTQVCARSLAVGKLEGVDGSRPYCTTDGVGAVLAVFHRDGLTGPVTRVVSVNQTGTPFVATYGGVPVEPATIGQDYQALGGVVTPVRGDAPAHPVVPADAVTASASGLDPDISPAYAALQVPRIARERGLTAQQVRELIAGHTDDRALGFLGEPGVNVLELNLALDGNR
>NC_021191.1|WP_015621217.1|3749104_3751588_+|sensor-histidine-kinase-KdpD
MARGELRIHLGAAPGVGKTYTMLEEAHRRAERGTDVVIGLVETHGRKHTEAMIGELEVIPRTQLRYRGAGFTEMDLDAVLARRPELAVVDELAHSNVPGARNAKRWQDVQELLAAGIDVLTTVNVQHLESLNDVVAQITGVEQRETVPDAVVRAAEQVELVDMTPEALRRRMAHGNIYQPEKIDAALGNYFRAGNLTALRELALLWLADKVEDQLDKYRADHKIDTRWETRERVVVALTGGREGGTLIRRAARIAARNKGADLLAVHIARNDGLNGADPAALSRQRVLVESLGGSYHQVVGADVPQALLDFARAVNATQIVLGASSRGRLAQLFTAGVGVTTTALSGTIDVHLVPHERAGAGRRAGRVPAALSRRRRVAGLVTVLAGLPVLTALLSIGAGLTLANDILVFLAAVVAVSLIGGLWPALIAAVAGSMLLNYFFTPPVRRFTIAEGENLLALGIFVVVALAVSWVVDTAARKTRQAAQAGADAQTLATVAGSVLRGDRPLIALMERLAEIFALRSVTLLDKGVVVAGVGDNPCVDAGESDVEVKVDDDLVVLLCGRPLAASDRRIVEAFAAQAAVALRQERLSAEAATAKPLAEADRMRTALLAAVSHDLRTPLASAKASVASLRSGDVDFDEQDRAELLETADVSLDRLIRLVTNLLDMSRLQTGALGVSATAIGAEEIVPRALDDLGPAGRTVALHIPDDLPLLSADPGLLERVLVNLSANALRHSPPGHPPMITASTLGSTVEIRVVDRGPGIPEDRWEDVFAPFQRLGDRDNHTGVGLGLALSRGLTEAMGGTLTPEATPGGGLTMTVSLPTAEPR
>NC_021191.1|WP_015621218.1|3751584_3752262_+|response-regulator
MTRILVVDDEPQIVRALSINLKARRYEVDAAPDGASALRLAGDRHPDLVVLDLGLPDMEGTEVIRGLRGWTTVPIIVLSGRVESNDKVDALDAGADDYITKPFGIDELLARIRAVTRRTRAPGEAAPTVTIGANTVELDTRRVRNGDREIRLTPTEWQLLEHLVRHPGKLHSQRALLHDVWGPQYLTESNYLRQYMARLRRKLEEDPARPRHLITEPGMGYRFRP
>NC_021191.1|WP_015621219.1|3752488_3753292_-|aldo/keto-reductase
MTQTKTLADGSGIPVLGLGVWQVSDGRECEDAVRWALEAGYRHIDTAQAYGNEQSVGRAVRGSGLARDEVYLTTKFNPARRDPVAELEQSLHRLGVDFVDLYLVHWPAGGPTRAWDGMQRAQQLGYARSIGVSNYSAADIRAVLAADVPPVVNQVQFSPFEYRRGLQEVCAGSGVALEAYSPLGTGRHLGDPEVAAIAEQTGRTPAQVLIRWSLQRGLIALPKSTHRDRIAQNAAVVDFELSDKQLATLDSLDRTQGTDRARESTWW
>NC_021191.1|WP_015621220.1|3753341_3754055_-|SDR-family-NAD(P)-dependent-oxidoreductase
MRVFITGSADGLGRATAATLLGDGHDVIVHARSTERLAAVRDLLDRGATGVTGDLADPGAVRSVADQVNQGGPVDAVIHNAGVLDSPDVMSVNVVAPYLLTALIGQPRRLVYLSSGMHRGGRADVSRVRGGGSYSDSKLLVTTLALAVARRWPGTTSNAVDPGWVPTRMGGPGAPDDLRLGHLTQEWLATGDDRRAATTGGYWFHQRQQEPHPAAKDKEFQDDLLTELADLTGTRLD
>NC_021191.1|WP_041833620.1|3754135_3754570_+|NUDIX-hydrolase
MAAGALLTDEQGRVLLVEPTYKPSFEIPGGTVEAGESPRAAVVRELEEELGLPVRPGRLLVVDWVPPRPGRTEGLMMLFDGGLLTPAQTGRIRLPPEELRSWAWCTEQQAAERLTELLARRIGAALRARAAGVVAYLENGFAVS
>NC_021191.1|WP_015621222.1|3754667_3755177_+|hypothetical-protein
MRALFVIAAAVLLGFVLSPMMRTDAATCTPRPAASALTGWSEEQVANARLIVTVGERRRVPVEGQVIAVATALQESRLRNLRGGDRDSVGLFQQRASQGWGTPRQLADPAYQTGKIYDKLLDVDGWQEMRLTDAAQAVQVSAYPGAYAKHARAATGLVDALSGAGSCPR
>NC_021191.1|WP_063643202.1|3755292_3755787_+|nuclear-transport-factor-2-family-protein
MTDTVFSSATVAGLADRAAITDTLHRYTAGLDLNDSGLLASALTEDAVVDLGPAMRRIGFDFPPLAPRDTVVSTLIGAVGPLDTSHAISNVRATVEGDTATVYAYAQAQHFKPGAGSDPAVTRHALMMNRYTATMVRAGEQWRIKHLDIANAWFDGDPLMLLGD
>NC_021191.1|WP_015621224.1|3755794_3757588_-|AfsR/SARP-family-transcriptional-regulator
MRFTLLGPIRALTGPAELPLGTPQQRGLLALLLLQDRPVPIDAIVDALWGDRPPASARSTVRTYSSRLRQTLARPGAPGPVLHRTAAGYRLDRGAATLDVTEFLDLLDRGAGLRRDGDAAGAAHALRQALDLWSGQALGGAQGEFAAAQRVRLDMARRTAREQWFDLQLELGEHESAAAGLAAAVSEEPLDGRLTELWMTALHRSGRTAAALAAFRALRAALRDELGIEPGARIQVLHQQILRGAPALAVTTDRGAPEQLPADLPVFTGRDEQVGWLRGTLTGPAPAVAGITGLGGSGKTALAVHAAHRLGDRFPDGRLFVELAARSGSPTPPLEVLAGLLRAVSPGVALPSTLAERSALWRTTVARRRLLVVLDDAADSAQVSPLLPGTPGCAVIVTATRRLLELPTVRWHRLGPLSETEALHLLGAVAGHDRVAREPQAAARLVGACSHQPLPVRVAAARLLDRPRWTIERIMAQLDDDLRQPVVMHEDCKIVDEPIRRAEAGLRPATARVFRIAALPGSPDRSVEDVTLMLRVSPAQARAALEELVDAHLVEETSTDRYRYPVLVQAYARRRADQVEGPGGCRAALELLAAVPA
>NC_021191.1|WP_015621225.1|3757698_3759174_-|long-chain-fatty-acid--CoA-ligase
MPNTGLGGWPARRAAISPDRTAMVFAGRTTTYAEFAGRVGRLTRRLHAAGVRPGDRVAYLGANHPAFVETMFATYAAGAIFVPLNARLAGPEIDYLLDHSGARLLIHAQPHATELPSVSLTEYEAWLAAGGDAPGPGVTVAGSDPACILYTSGTTGRPKGAVLTHDNIVWNTYNLLVGVDVAGDEVTLVSAPLFHVAALHQCLLPTVLKGGCSVLMPGWDVDGCYDLIDRHRVTWMFGVTAMYAALAASPRWPGADLGSIRRLLVGGAAVPPALIHTYQQRGLTFCQGYGMTETAPGATFLEAPEAAAHPGSAGPPVFFADVRCVRPDLTETGPGEPGEVLVRGPNVTPGYWNDPGATRDAFTGGWFRSGDIAVVDEHGHFRIVDRVKDMYISGGENVYPAEVEAVLFAHPTVAEAAVVGVPDDTWGETGRAFLVPAPGHDIDADEIRTFLTGRLARYKIPRYIDTVAALPRTGSAKVRKEALRALPLPAA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_9

4416540-4416647

Orphan

Consensus_repeat	Method
CGGGCCGCTCCTGCCGCACTGCCG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_021191_9

>merge|NC_021191|9|4416540-4416647|CRISPRCasFinder
CGGGCCGCTCCTGCCGCACCGCCGGGCCGCCGGGCCGCTCCTGCCGCACTGCCGCACTGCCGCACTGCCGCACCGCCGGGCCGTCGGGCCGCTCCTGCCGCACTGTCG

>NC_021191|9|9|4416540-4416647|CRISPRCasFinder
CGGGCCGCTCCTGCCGCACCGCCG	GGCCGCCGGGCCGCTCCTGCCGCACTGCCGCACTGCCGCACTGCCGCACCGCCGGGCCGT
CGGGCCGCTCCTGCCGCACTGTCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_041832341.1\|4416681_4417953_-\|lipase	unknown	unknown	gnl\|CDD\|238881
NC_021191.1\|WP_015621789.1\|4426519_4427014_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NC_021191.1\|WP_084504185.1\|4423437_4425711_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379062
NC_021191.1\|WP_051167785.1\|4409411_4410365_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236196
NC_021191.1\|WP_015621784.1\|4418865_4420929_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200452
NC_021191.1\|WP_015621792.1\|4427832_4428312_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176908
NC_021191.1\|WP_015621775.1\|4408948_4409311_+\|DUF2203-domain-containing-protein	unknown	unknown	gnl\|CDD\|378330
NC_021191.1\|WP_015621773.1\|4405889_4406381_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NC_021191.1\|WP_015621785.1\|4420944_4423326_+\|DUF1929-domain-containing-protein	unknown	unknown	gnl\|CDD\|199882
NC_021191.1\|WP_015621772.1\|4405036_4405885_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_084504183.1\|4410949_4411405_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NC_021191.1\|WP_015621783.1\|4418170_4418731_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NC_021191.1\|WP_157408811.1\|4411446_4411983_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NC_021191.1\|WP_157408408.1\|4425751_4426462_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_021191.1\|WP_084504184.1\|4412299_4414033_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379588
NC_021191.1\|WP_015621781.1\|4414291_4415791_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341047
NC_021191.1\|WP_157408409.1\|4427024_4427189_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015621791.1\|4427317_4427836_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_021191.1\|WP_015621777.1\|4410428_4410998_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
NC_021191.1\|WP_157408407.1\|4406562_4408950_-\|M4-family-peptidase	unknown	unknown	gnl\|CDD\|341060

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_041832341.1\|4416681_4417953_-\|lipase	gnl\|CDD\|238881	cd01844, SGNH_hydrolase_like_6, SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.36849e-57
NC_021191.1\|WP_015621789.1\|4426519_4427014_-\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	4.99215e-33
NC_021191.1\|WP_084504185.1\|4423437_4425711_+\|ATP-binding-protein	gnl\|CDD\|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	7.8975e-06
NC_021191.1\|WP_051167785.1\|4409411_4410365_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236196	PRK08241, PRK08241, RNA polymerase subunit sigma-70.	1.51622e-166
NC_021191.1\|WP_015621792.1\|4427832_4428312_+\|SRPBCC-family-protein	gnl\|CDD\|176908	cd08899, SRPBCC_CalC_Aha1-like_6, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	1.34782e-38
NC_021191.1\|WP_015621775.1\|4408948_4409311_+\|DUF2203-domain-containing-protein	gnl\|CDD\|378330	pfam09969, DUF2203, Uncharacterized conserved protein (DUF2203). This domain, found in various hypothetical bacterial proteins, has no known function.	6.22892e-44
NC_021191.1\|WP_015621773.1\|4405889_4406381_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	2.35809e-34
NC_021191.1\|WP_015621785.1\|4420944_4423326_+\|DUF1929-domain-containing-protein	gnl\|CDD\|199882	cd02851, E_set_GO_C, C-terminal Early set domain associated with the catalytic domain of galactose oxidase. E or "early" set domains are associated with the catalytic domain of galactose oxidase at the C-terminal end. Galactose oxidase is an extracellular monomeric enzyme which catalyzes the stereospecific oxidation of a broad range of primary alcohol substrates and possesses a unique mononuclear copper site essential for catalyzing a two-electron transfer reaction during the oxidation of primary alcohols to corresponding aldehydes. The second redox active center necessary for the reaction was found to be situated at a tyrosine residue. The C-terminal domain of galactose oxidase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase, among others.	2.61395e-28
NC_021191.1\|WP_084504184.1\|4412299_4414033_+\|flippase-like-domain-containing-protein	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	4.32151e-32
NC_021191.1\|WP_084504183.1\|4410949_4411405_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	1.83218e-11
NC_021191.1\|WP_015621783.1\|4418170_4418731_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	4.93434e-18
NC_021191.1\|WP_157408811.1\|4411446_4411983_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.69405e-12
NC_021191.1\|WP_157408408.1\|4425751_4426462_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.42321e-12
NC_021191.1\|WP_015621784.1\|4418865_4420929_+\|hypothetical-protein	gnl\|CDD\|200452	cd11313, AmyAc_arch_bac_AmyA, Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase). AmyA (EC 3.2.1.1) catalyzes the hydrolysis of alpha-(1,4) glycosidic linkages of glycogen, starch, related polysaccharides, and some oligosaccharides. This group includes firmicutes, bacteroidetes, and proteobacteria. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	4.52873e-14
NC_021191.1\|WP_015621781.1\|4414291_4415791_+\|MFS-transporter	gnl\|CDD\|341047	cd17504, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.5513e-81
NC_021191.1\|WP_015621791.1\|4427317_4427836_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.33901e-17
NC_021191.1\|WP_015621777.1\|4410428_4410998_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	8.34599e-104
NC_021191.1\|WP_157408407.1\|4406562_4408950_-\|M4-family-peptidase	gnl\|CDD\|341060	cd09597, M4_TLP, Peptidase M4 family including thermolysin, protealysin, aureolysin, and neutral protease. This peptidase M4 family includes several endopeptidases such as thermolysin (EC 3.4.24.27), aureolysin (the extracellular metalloproteinase from Staphylococcus aureus), neutral protease from Bacillus cereus, protealysin, and bacillolysin (EC 3.4.24.28). Typically, the M4 peptidases consist of a presequence (signal sequence), a propeptide sequence, and a peptidase unit. The presequence is cleaved off during export while the propeptide has inhibitory and chaperone functions and facilitates folding. The propeptide remains attached until the peptidase is secreted and can be safely activated. All peptidases in this family bind a single catalytic zinc ion which is tetrahedrally co-ordinated by three amino acid ligands and a water molecule that forms the nucleophile on activation during catalysis. The active site is found between two sub-domains; the N-terminal domain contains the HEXXH zinc-binding motif while the helical C-terminal domain, which is unique for the family, carries the third zinc ligand. These peptidases are secreted eubacterial endopeptidases from Gram-positive or Gram-negative sources that degrade extracellular proteins and peptides for bacterial nutrition. They are selectively inhibited by Steptomyces metalloproteinase inhibitor (SMPI) as well as by phosphoramidon from Streptomyces tanashiensis. A large number of these enzymes are implicated as key factors in the pathogenesis of various diseases, including gastritis, peptic ulcer, gastric carcinoma, cholera and several types of bacterial infections, and are therefore important drug targets. Some enzymes of the family can function at extremes of temperatures, while some function in organic solvents, thus rendering them novel targets for biotechnological applications. Thermolysin is widely used as a nonspecific protease to obtain fragments for peptide sequencing. It has also been used in production of the artificial sweetener aspartame.	3.13381e-108

>NC_021191.1|WP_015621781.1|4414291_4415791_+|MFS-transporter
MTQTVGQAGSPGTTSGAERPSGGGMLVLYLSLGGLAFAVLQSLVAPALGTIGRELKADTSDASWVITAYLLSASVLTPILGRLGDMAGKRKVLIGVLVTLAAGTAVAALAPNLAVLIVARALQGAAGAILPLSIGIVRDELPRERVATTVGLLSAIFGVGAGVGIVAAGPIVEHLSWHWLFWLPLVLVIVALLGVILGMKESPVRTPGRLDLAGTAILSVSLVSLLLAISKGQTWGWGDAKTVVLLAVGVVTLVTFVLVELRVREPLIDMRLMKIRGVWATDLVALILGFAMFGTFLLVPTLLQLPAATGYGFGKSVSQSGLFLLPTVVMMVLFGPIAGILTKKFGPKLPMFLGAIFVVAAFTLPALSHGEIWQVLASGVLTGAGIGFAFAAMSNAIIESVPATQTGEATSVNTIARTIGSSIGTAVVAAVITSHTTAQGLPTDDAFTYGFWACAGVAVLAIVAALILPSAHRRHEEAVAHGVADLPPEPAELHLPHRN
>NC_021191.1|WP_084504184.1|4412299_4414033_+|flippase-like-domain-containing-protein
MTAPTPVVAIPRPRVAPDGGQRPSRGAAVWKALRELLLVTVLFLAYKAGRVFTAGHTREAMVNAGDVWHFERLVHLPNEVIVQHALLVHHWIVIAANSYYAYVHFPATAATLIYLYARRPGLYLRTRRVLAVLTATALVVHVLFPLAPPRLATGSGLLDTGTLYGPGVYGPPDTDTLSNQYAAMPSLHVGWAVVVAVALASASRGRWRWLWLAHPVLTLTVVVGTGNHYWLDAIVVLILLFVVAVFLVPPVRRAVRSAGAWLRRRWVRVLAWTAAIVAMVAALRGRLPDPAAVVSALGDADPRWLAVAVLAQLCSQAAFAKQQRTLLSALAVALSRRAALAITYTRSAMSLVLPAGSAMSAAFAVRQYRRYGATTAVAATGMVLSAVASVVGLSLLYLGVVSAWALVALAGAGVLGCALFLRRRRLPHPGAAREAFRSRWHWVDRAFDGVRRIGREARAVRLRHWAVTIAFAMLNWLLDLVCLIAVARACGLSLSVPPIATVYLAAQIVRQIPLTPGGVGLIEASLLTGLVAAGAPQATAAAVVLGYRIVSFWLLLPAGLAAYLRLSRFDRTAPAEA
>NC_021191.1|WP_157408811.1|4411446_4411983_-|TetR-family-transcriptional-regulator
MLDKARWRFARDGYAATTVRDIADDAGVNVALINRYFTSKEGLFEACLRTAGSEMRQDADDLTFDGIAAAMASRIAGASMPGEVHDALLLLLRTSGDERIDELRRAVLQSVSEKLARAANGPDISPEALLRAQVVLGTTLGITLLRASMGLQPLAEATPEDLLGPLTDLVNALLPVPR
>NC_021191.1|WP_084504183.1|4410949_4411405_-|helix-turn-helix-transcriptional-regulator
MSLLRVAIGAVLRRLRHRQGRTLQDVADAAGVSLPYLSEIERGRKEASSEVLAGICRALGIGLPDLLDEVRHELLRTAPSRRLTMRSDPGRSPGSLPARGHPAGTIRTAGAFSAGSRSAGSREKRSSGFRTPRLAVCRTLSPMASSSPTNS
>NC_021191.1|WP_015621777.1|4410428_4410998_-|ATP-dependent-Clp-protease-proteolytic-subunit
MQNAQPHGLQLTDELLKQRIIFLGTEVNDESANALCAQLLLLSAADPARDIQFYINSPGGSVTAGMAVYDTMRFIPNDVATIGIGLAGSMGQFLLTAGTAGKRYALPHTRIMMHQAAGGIGGTAADITIQAENMLFVKRQMHELIARHSGRPVAQIAEDSDRDRWFTADQARDYGLIDDVITEAAAVPA
>NC_021191.1|WP_051167785.1|4409411_4410365_+|sigma-70-family-RNA-polymerase-sigma-factor
MIDDLENYRRELTGYCYRMLGSAFEAEDAVQDTMIRAWRGLDRFEGRAALRSWLYRIATNVCLTMLEGAQRRARPVDLGPPGSGHATDPGEPRPEQVWTGPIPDQRCSDPADVVAGRESIRLAFIAALQHLPPRQRAVLILREVLAWSAQEVADLLDTSVPSVNSALQRARATLATVDPAAAEPYQPADDKQRELLSRYVRAFEAYDLTALAALLHEDATLSMPPLPLWLRGRADIRTWMEGLGNGCEGSRLLPVTANGLPAFGQFRPDPAGGHTPWALIVLELRAGRIAGIATFLDTDRLFPLFGLPPHVDGTAAG
>NC_021191.1|WP_015621775.1|4408948_4409311_+|DUF2203-domain-containing-protein
MGLFTLVEARAELARLQPVLAEIVTVRADMVELSAALAVGGQPSPLGGLPERKAAEARLNELMTAVQETGAELKGIAPLLVDFPGELDGVPVLLCWLEGETGLGWYHRADLGFGGRRPLP
>NC_021191.1|WP_157408407.1|4406562_4408950_-|M4-family-peptidase
MGGSLPARATQSNHCQPGKFEESSLFNIQPLRHSIDSSRCHDLGRNGLRSALALAGVILLAGGGIAVTATGASAAPPPAPAPALLADAGAALRDHAAAVKGSALDRYAVYSSKKDAQGRGVVRYTRTYQGLRVYGGDIVIRLGADGAYTGSSVGLAAPLDLSVTPKVSAAKASVAARKAFPGTITGTAQPELFIDASSGKPVLAWETVLTGWAKDGQTPAKLHVITDAGTGAVRGSFDEIETVDGTGNSIYSGPVTIGTTRSTTGYTLVDPDRGNGRTCDLNNGTSTCTTFTDADNVWGTGTTADRASAAVDAHFGAAITFDYFKNVHGRNGIFGTGAGVPSRVHYGNAYVNAFWDGAQMTYGDGERNAKPLVALDVAGHEMSHGVTENVVPGGLTYSGESGGLNEATSDIFGTMVEFYANTTSDPGDYDIGEKIDIDGTGEPLRYMYDPARDGISHGCWSTSTNSVDVHYSSGVANHFFFDLAEGTGATAYGTSPICGSAEPVTGIGREKAEKIWFRALDTYFVSNTKYVNPAAPSNTARAYSLSAAADLYGLCGTEYKAVQAAWTAVNVAGSDYCPTDHDFAIAASPATVTLDRGETVTTDVTTTVTNGTPETVTLSATGVPAGATVSFSQDEITAGESATVTVSAADSLSTGTYPISIVGTSPSVRHATTFTVSVRSAGGCAGANSTRVDIPDNTTVTSTIDLTGCSATPSVTSAVEVHIVHTYIGDLVVSLVAPDGTAYILSNRAGGSTDNIDQTYTVNLSGESASGVWTLRVQDAATIDTGYISNWKLSL
>NC_021191.1|WP_015621773.1|4405889_4406381_+|SigE-family-RNA-polymerase-sigma-factor
MTNDHDFETFARAGAERLRSTAFMLCRDWHLAQDLTQTTLTKLYVAWRKVAQADNPHAYAQKVLFRAYLDHRRRRSSAETATAEFVEIAEAASPDLRLTMLEALAQLPPRDRAIVVLRYFEDYSVDQTADVLNIPATVVKTQTKRSLLRLRGLLAPDQLALFA
>NC_021191.1|WP_015621772.1|4405036_4405885_+|hypothetical-protein
MTEDLRALMRAELSEERPPPLGDLVATAMRDGRRITRRRRFAMVGASAAVLAVAVGGAAVAWPAGGGRQLDSPAAVGSGSSAPPSVSATPEPTPSGSAVPRRFPSDEPEASTGTGARPTPMTVRLQGQHVRTKQLPATPESVLELLTRLLPKGKVSKLAANAEDGLFAQVYLDTGKGPGMLRVWLKPYDDPDLKPGTVVIETFTTPDNCVQSTVVNASYSTGGHVEMNIATCLGSDREPAPAPITVDEAVKVLSDARWGVRMDAELVAEGAKHYAGIPASAR
>NC_021191.1|WP_041832341.1|4416681_4417953_-|lipase
MISVPLTADLLRGACELERTERGLLPHRLPAWARAQTPDPQLAMMEAQPSGVRLTLRTRATTIELDTLPTRLVYPGFPPRPEGVYDVLINGVLAARSTADGGNTITVTMSDGTTSFAHGEVATLRFDLPEMPDASTAGPRNGRPGAASSRPHDDRPRASTGGRPVSPGVGAGRDRIVEIWLPHNERTELVALRADAPVEPAPPSGRPVWLHHGSSISHGSNAATPSGTWPALAATQAGVELINLGLGGSALLDPFIARFIRDSHVDVISIKMGINIVNADAMQVRTFGPAVHGFIDTIRDGHPDTPLMFVSPIFCPIHEDTPGPGAFDLEALREGKVAFRATGRPGPGKLTLRVIRDELARIVGQRSAEDKNLHYLDGLALYGEADADELPLPDRLHPDAATHRLIGTRFADLGLHPLLSHPA
>NC_021191.1|WP_015621783.1|4418170_4418731_-|TetR/AcrR-family-transcriptional-regulator
MARAGLTTERLVRAGAELADEVGFAGVTVSALARQFDVKVASLYSHVQSSQDLRTRIALLALAELADLVTDALAGRSGKDALVALANVYRDYAREHPGRYAAAHLPLDDETAAASAGPQHARMTRALLRGYHLTEPDATHAVRLLGAVFHGYVTLESEGGFSHSKPSSDESWTWALDALDTLLRRA
>NC_021191.1|WP_015621784.1|4418865_4420929_+|hypothetical-protein
MGFGTAQVRAGTDRVELRPGEKLTVGLGVTADDADELTGAQAFVWTNYGNGDPRVFTAVPMHPVRPRDAHQVAFEATLPPAGLGTVIATAYVEIGGVRHWAQDHAPPREHNLHNRLVFRVHDRSVEGLFVRQVPIDKANARSGSTDISTIDDMVTEGSGFYNVDLLSFDGVGCVWLQVPYRLDLWDGLDAVDDAGSDYASTDWFSIDPELSLAARMVPGWDLDRQRDLANAAMRRLVDRAHERGMKVLLEIAPNHVGHNFIFRDNFDENGDDVRRRDYRQMVVDDAQLAQVEQRLNGPMDERVKEYAEWMLPQMYAGHFPDGHYNPFGAASVDETYSPDWYGTWLDVKHLNHGGHPGERIWYPRTRQNELVLAYIGRVMAWAATELGADGFRIDHALGMPYLFFEQTLPWVEMKVRQRRGPQASLLLIPEDHDRKDYSARVGDVIQSKGYEQLLDAFTHQNLEGIWGFYDSPHLTAEFAGTGNHDEVRGSEFFAGDLLAYGNAVITMQLMGGPMTMLAGDEFGEGQKLRFKSRGGIPTLWQLRQNTLPGANTELAFWVARGGKLRTSHPALGTADRERLRWREAANPGRLLAFARAAGNPDVAPLLCFNNLDRHDWLTGTAELGDFARAWLDRQPDAHLQVRDLLGLDPLRPLWRQPLTAKELLTTGLHVGLQPYQIQVLELTRVAA
>NC_021191.1|WP_015621785.1|4420944_4423326_+|DUF1929-domain-containing-protein
MATKFLDIPDWTSFDNEGGGTAVADISGSGRPDLVVFRVDDGPGQNAGSYRIGWDLDAEGEVTGGWSPWFAVPEWFAWHNDGSGIAVADLDGDGRPELIVLQIDAPDGPNRGVYRIGRRLSATGEVTGGWTPWIDVPDWFPWHNQGAGIAVSTLTGHRHDLVVLHVDAPEGANTGYYRVGRGLDASGAVTQGWGPWIAVPDWFFWENQGAGVALADLDGDGRPELLVFAVDNPPGANSGAYQIGWKLDADGVVTEGWSPWTAVPDWFFWENQGAGVDLADLDGDGRPELVLSVVDAPVGANLGFYRTLGLVLDRDVAAQQGVWRLQNETSQSLAIHAAALHTDEVLFFSGSSNNPENVGTKNRGVRWHPQHHTVTDAAVPADFFCAGHAQLPDGGLLVAGGTAEYDTGHPFLGLKDAWTFDPDAGWHREPDMAGGRWYPTLVTLADGHVVAFAGTNEHGDLNLVPEIWSPDGGWFALPPLPQWHGQPRVPQYAQLFLLADGRLFFSGACYGTNEGTGPGLLDLVQHSWTEVGGLDDHVERNHRNQAASVLLPPAQDQRVLLIGGGEDFGHHGRHAIDAVNIVDLTETDPHYVKAPKLPTPRMHHVAVLLPDRTVLVTGGSGGDESRPDATNEALLFDPAHPGWAAKAKARVIRLYHSVALLLADGTVVTAGSNPARGDEEYRIERYYPPYLFRGPRPVVDDVPDHLHRGSAITLTCPQAADVKWVSLTRAGSTTHCLNTDQRLVDLPIGARGAGTLDVTVPAGTSLLPPGYYLLTVTDDAGVPSIGRWTRVVL
>NC_021191.1|WP_084504185.1|4423437_4425711_+|ATP-binding-protein
MVVAAFRSRASTSWCSALSPGVDAPGPTLNAVTLFGRRREIVAIERLLDRAKDGTGGILVIGGPPGSGKTALADAAAAAARLRGLPVDRTGNPGRGPSLLVLDGVATPDAPAAPDAPAGLDREKLAAGGAAVLVTTTGAGDLTLAPLSEAELGWLLPGRTAAVVHAIWLASGGLPGPALGLAAIVAEDEADAVAGLALRAPSRAEFLHLDVALLRLVEFAAARPLPPPVRARVLIRWARELLGDPSAGPRRRELAAEALRTARDSGDPRALAEVLDGRLHALWEPVAAAERLSTASEIVKLARQAGDAGVELRGLFWRFTALAELGDLDAAEAALVTYARTAELAGDAQAAVMALSRQAVLALVRGRLELVETLTEEVADAGRRAGLADTGRLTASLSGALAVLRGRAAEHVATLQQMARRLPGHFYEATAARLLVEAGRDAEAVLELDRLLPAVLAGSGPRWLGAVADLAFVAARGGDAEAVRMLYDALTPYRGRLVVWGGANMITGPVDDLLGRLAARLGRSAEALGHLDRAVAQEERLGALPWLCATLTARDRPGDRERARSLASRLGIAVAHGDEWRLLRDGDEWSLEAGAERARLKDVRGLHYLRLLLAAPGREIPALDLVAGGAGLRAPAGDAMLDVAARTAYRHRLSTIDQQVDEADRAGDVDRAGELAAERAALVGQLLSATGLGGRPRRPSAEAERARVNATRALSAVLTRLETAAPLVAGHLRASLRTGSHFRYQPASGGPQRWRVS
>NC_021191.1|WP_157408408.1|4425751_4426462_-|alpha/beta-fold-hydrolase
MTDLLLIHGLTYDRRAWGPLRRHLSPGRRVLAVDLPGHGSSPRQDSYPLAGVVAAVHEHVVEAGLSDPVVVGHSAGAVIAHAYAARFPVTAVVNIDQAVLPSPFFAAVRAAEPLLRGPRWEEFWNRMLAGMGITGLPAEARELVETATDPRPDILLGYWDDILRLSDDELTAQRTRELAAMATRGVGYHWVTSSEPPEPYLRWLRSALPEAEVTVLPGGHFPHLAAPAELAALVPA
>NC_021191.1|WP_015621789.1|4426519_4427014_-|DinB-family-protein
MLESQRERVPLDDGGEADTALAFLSFARSCVLKKLDGLDEDQLRRRLVVSDTTLLGLVQHLTDAERYWFGWTLAGDTRHAGVDFTMVVDPERSAADVIAAYRAAITESDDHIRTAAGLEARTAQPVNDKAMTLRWVIAHMTGETVRHAGHADILRELIDGVTGR
>NC_021191.1|WP_157408409.1|4427024_4427189_-|hypothetical-protein
MTDLEGVLVFAGVPLAVIAVVFALVFLTTKKPSREPITKPLLDGTSPHRTDGQH
>NC_021191.1|WP_015621791.1|4427317_4427836_+|winged-helix-turn-helix-transcriptional-regulator
MDEAAGAIADPVRREILVMLRAAPHSAGQLADRFAISRPAVSRHLRVLREAGLVRAAAEGRRRVYTLVTDPLDELAGWLAQLLGADALAASPLAGRRAASPLAGARATSPLAGPGAVSPPAGSGAHVPAVTATAGRQRPGGWEQRLDALATEVHRTRRERRTVHPDEEGRTA
>NC_021191.1|WP_015621792.1|4427832_4428312_+|SRPBCC-family-protein
MNPTPTGRLSGNDLVLTRTFRAPIGAVWASITESDRTARWFGPWQGEAAPGGAIKVQMVLEQGEPWIDMVIAACEPPRRLVVSAGAGAESWHLELMLTETAGVTELRFIQHLTGTENVGEVGPGWEFYLDALVAARENRPAPVFDDYYPAQKSHFEAQR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_10

4427581-4427723

Orphan

Consensus_repeat	Method
GGCCGCCTCGCCGCTCGCCGGCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_021191_10

>merge|NC_021191|10|4427581-4427723|CRISPRCasFinder
GGCCGCCTCGCCGCTCGCCGGCCGCAGGGCCGCCTCGCCGCTCGCCGGCGCCAGGGCCACCTCGCCGCTCGCCGGCCCTGGCGCTGTGTCGCCGCCTGCTGGGTCCGGCGCACACGTCCCGGCGGTCACCGCGACCGCCGGCC

>NC_021191|10|10|4427581-4427723|CRISPRCasFinder
GGCCGCCTCGCCGCTCGCCGGCC	GCAGGGCCGCCTCGCCGCTCGCCGGCGCCAG
GGCCACCTCGCCGCTCGCCGGCC	CTGGCGCTGTGTCGCCGCCTGCTGGGTCCGGCGCACACGTCCC
GGCGGTCACCGCGACCGCCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015621789.1\|4426519_4427014_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NC_021191.1\|WP_041832341.1\|4416681_4417953_-\|lipase	unknown	unknown	gnl\|CDD\|238881
NC_021191.1\|WP_015621794.1\|4430238_4430784_-\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232
NC_021191.1\|WP_015621800.1\|4437442_4438210_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_084504185.1\|4423437_4425711_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379062
NC_021191.1\|WP_157408411.1\|4437051_4437405_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_041832344.1\|4438559_4439165_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
NC_021191.1\|WP_015621792.1\|4427832_4428312_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176908
NC_021191.1\|WP_157408410.1\|4431004_4434136_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276938
NC_021191.1\|WP_015621785.1\|4420944_4423326_+\|DUF1929-domain-containing-protein	unknown	unknown	gnl\|CDD\|199882
NC_021191.1\|WP_084504184.1\|4412299_4414033_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379588
NC_021191.1\|WP_157408812.1\|4428378_4429593_-\|pectate-lyase	unknown	unknown	gnl\|CDD\|214765
NC_021191.1\|WP_015621783.1\|4418170_4418731_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NC_021191.1\|WP_157408408.1\|4425751_4426462_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NC_021191.1\|WP_157408409.1\|4427024_4427189_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015621797.1\|4434907_4435768_-\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NC_021191.1\|WP_015621781.1\|4414291_4415791_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341047
NC_021191.1\|WP_015621796.1\|4434277_4434898_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015621798.1\|4435796_4437005_-\|low-temperature-requirement-protein-A	unknown	unknown	gnl\|CDD\|377704
NC_021191.1\|WP_015621784.1\|4418865_4420929_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200452

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015621789.1\|4426519_4427014_-\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	4.99215e-33
NC_021191.1\|WP_041832341.1\|4416681_4417953_-\|lipase	gnl\|CDD\|238881	cd01844, SGNH_hydrolase_like_6, SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.36849e-57
NC_021191.1\|WP_015621794.1\|4430238_4430784_-\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	1.8404e-05
NC_021191.1\|WP_084504185.1\|4423437_4425711_+\|ATP-binding-protein	gnl\|CDD\|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	7.8975e-06
NC_021191.1\|WP_041832344.1\|4438559_4439165_-\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	0.00152336
NC_021191.1\|WP_015621792.1\|4427832_4428312_+\|SRPBCC-family-protein	gnl\|CDD\|176908	cd08899, SRPBCC_CalC_Aha1-like_6, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	1.34782e-38
NC_021191.1\|WP_157408410.1\|4431004_4434136_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	9.11707e-43
NC_021191.1\|WP_015621785.1\|4420944_4423326_+\|DUF1929-domain-containing-protein	gnl\|CDD\|199882	cd02851, E_set_GO_C, C-terminal Early set domain associated with the catalytic domain of galactose oxidase. E or "early" set domains are associated with the catalytic domain of galactose oxidase at the C-terminal end. Galactose oxidase is an extracellular monomeric enzyme which catalyzes the stereospecific oxidation of a broad range of primary alcohol substrates and possesses a unique mononuclear copper site essential for catalyzing a two-electron transfer reaction during the oxidation of primary alcohols to corresponding aldehydes. The second redox active center necessary for the reaction was found to be situated at a tyrosine residue. The C-terminal domain of galactose oxidase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase, among others.	2.61395e-28
NC_021191.1\|WP_084504184.1\|4412299_4414033_+\|flippase-like-domain-containing-protein	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	4.32151e-32
NC_021191.1\|WP_157408812.1\|4428378_4429593_-\|pectate-lyase	gnl\|CDD\|214765	smart00656, Amb_all, Amb_all domain.	2.94334e-49
NC_021191.1\|WP_015621783.1\|4418170_4418731_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	4.93434e-18
NC_021191.1\|WP_157408408.1\|4425751_4426462_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.42321e-12
NC_021191.1\|WP_015621797.1\|4434907_4435768_-\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	3.20422e-74
NC_021191.1\|WP_015621781.1\|4414291_4415791_+\|MFS-transporter	gnl\|CDD\|341047	cd17504, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.5513e-81
NC_021191.1\|WP_015621798.1\|4435796_4437005_-\|low-temperature-requirement-protein-A	gnl\|CDD\|377704	pfam06772, LtrA, Bacterial low temperature requirement A protein (LtrA). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes.	7.77817e-76
NC_021191.1\|WP_015621784.1\|4418865_4420929_+\|hypothetical-protein	gnl\|CDD\|200452	cd11313, AmyAc_arch_bac_AmyA, Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase). AmyA (EC 3.2.1.1) catalyzes the hydrolysis of alpha-(1,4) glycosidic linkages of glycogen, starch, related polysaccharides, and some oligosaccharides. This group includes firmicutes, bacteroidetes, and proteobacteria. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	4.52873e-14

>NC_021191.1|WP_157408409.1|4427024_4427189_-|hypothetical-protein
MTDLEGVLVFAGVPLAVIAVVFALVFLTTKKPSREPITKPLLDGTSPHRTDGQH
>NC_021191.1|WP_015621789.1|4426519_4427014_-|DinB-family-protein
MLESQRERVPLDDGGEADTALAFLSFARSCVLKKLDGLDEDQLRRRLVVSDTTLLGLVQHLTDAERYWFGWTLAGDTRHAGVDFTMVVDPERSAADVIAAYRAAITESDDHIRTAAGLEARTAQPVNDKAMTLRWVIAHMTGETVRHAGHADILRELIDGVTGR
>NC_021191.1|WP_157408408.1|4425751_4426462_-|alpha/beta-fold-hydrolase
MTDLLLIHGLTYDRRAWGPLRRHLSPGRRVLAVDLPGHGSSPRQDSYPLAGVVAAVHEHVVEAGLSDPVVVGHSAGAVIAHAYAARFPVTAVVNIDQAVLPSPFFAAVRAAEPLLRGPRWEEFWNRMLAGMGITGLPAEARELVETATDPRPDILLGYWDDILRLSDDELTAQRTRELAAMATRGVGYHWVTSSEPPEPYLRWLRSALPEAEVTVLPGGHFPHLAAPAELAALVPA
>NC_021191.1|WP_084504185.1|4423437_4425711_+|ATP-binding-protein
MVVAAFRSRASTSWCSALSPGVDAPGPTLNAVTLFGRRREIVAIERLLDRAKDGTGGILVIGGPPGSGKTALADAAAAAARLRGLPVDRTGNPGRGPSLLVLDGVATPDAPAAPDAPAGLDREKLAAGGAAVLVTTTGAGDLTLAPLSEAELGWLLPGRTAAVVHAIWLASGGLPGPALGLAAIVAEDEADAVAGLALRAPSRAEFLHLDVALLRLVEFAAARPLPPPVRARVLIRWARELLGDPSAGPRRRELAAEALRTARDSGDPRALAEVLDGRLHALWEPVAAAERLSTASEIVKLARQAGDAGVELRGLFWRFTALAELGDLDAAEAALVTYARTAELAGDAQAAVMALSRQAVLALVRGRLELVETLTEEVADAGRRAGLADTGRLTASLSGALAVLRGRAAEHVATLQQMARRLPGHFYEATAARLLVEAGRDAEAVLELDRLLPAVLAGSGPRWLGAVADLAFVAARGGDAEAVRMLYDALTPYRGRLVVWGGANMITGPVDDLLGRLAARLGRSAEALGHLDRAVAQEERLGALPWLCATLTARDRPGDRERARSLASRLGIAVAHGDEWRLLRDGDEWSLEAGAERARLKDVRGLHYLRLLLAAPGREIPALDLVAGGAGLRAPAGDAMLDVAARTAYRHRLSTIDQQVDEADRAGDVDRAGELAAERAALVGQLLSATGLGGRPRRPSAEAERARVNATRALSAVLTRLETAAPLVAGHLRASLRTGSHFRYQPASGGPQRWRVS
>NC_021191.1|WP_015621785.1|4420944_4423326_+|DUF1929-domain-containing-protein
MATKFLDIPDWTSFDNEGGGTAVADISGSGRPDLVVFRVDDGPGQNAGSYRIGWDLDAEGEVTGGWSPWFAVPEWFAWHNDGSGIAVADLDGDGRPELIVLQIDAPDGPNRGVYRIGRRLSATGEVTGGWTPWIDVPDWFPWHNQGAGIAVSTLTGHRHDLVVLHVDAPEGANTGYYRVGRGLDASGAVTQGWGPWIAVPDWFFWENQGAGVALADLDGDGRPELLVFAVDNPPGANSGAYQIGWKLDADGVVTEGWSPWTAVPDWFFWENQGAGVDLADLDGDGRPELVLSVVDAPVGANLGFYRTLGLVLDRDVAAQQGVWRLQNETSQSLAIHAAALHTDEVLFFSGSSNNPENVGTKNRGVRWHPQHHTVTDAAVPADFFCAGHAQLPDGGLLVAGGTAEYDTGHPFLGLKDAWTFDPDAGWHREPDMAGGRWYPTLVTLADGHVVAFAGTNEHGDLNLVPEIWSPDGGWFALPPLPQWHGQPRVPQYAQLFLLADGRLFFSGACYGTNEGTGPGLLDLVQHSWTEVGGLDDHVERNHRNQAASVLLPPAQDQRVLLIGGGEDFGHHGRHAIDAVNIVDLTETDPHYVKAPKLPTPRMHHVAVLLPDRTVLVTGGSGGDESRPDATNEALLFDPAHPGWAAKAKARVIRLYHSVALLLADGTVVTAGSNPARGDEEYRIERYYPPYLFRGPRPVVDDVPDHLHRGSAITLTCPQAADVKWVSLTRAGSTTHCLNTDQRLVDLPIGARGAGTLDVTVPAGTSLLPPGYYLLTVTDDAGVPSIGRWTRVVL
>NC_021191.1|WP_015621784.1|4418865_4420929_+|hypothetical-protein
MGFGTAQVRAGTDRVELRPGEKLTVGLGVTADDADELTGAQAFVWTNYGNGDPRVFTAVPMHPVRPRDAHQVAFEATLPPAGLGTVIATAYVEIGGVRHWAQDHAPPREHNLHNRLVFRVHDRSVEGLFVRQVPIDKANARSGSTDISTIDDMVTEGSGFYNVDLLSFDGVGCVWLQVPYRLDLWDGLDAVDDAGSDYASTDWFSIDPELSLAARMVPGWDLDRQRDLANAAMRRLVDRAHERGMKVLLEIAPNHVGHNFIFRDNFDENGDDVRRRDYRQMVVDDAQLAQVEQRLNGPMDERVKEYAEWMLPQMYAGHFPDGHYNPFGAASVDETYSPDWYGTWLDVKHLNHGGHPGERIWYPRTRQNELVLAYIGRVMAWAATELGADGFRIDHALGMPYLFFEQTLPWVEMKVRQRRGPQASLLLIPEDHDRKDYSARVGDVIQSKGYEQLLDAFTHQNLEGIWGFYDSPHLTAEFAGTGNHDEVRGSEFFAGDLLAYGNAVITMQLMGGPMTMLAGDEFGEGQKLRFKSRGGIPTLWQLRQNTLPGANTELAFWVARGGKLRTSHPALGTADRERLRWREAANPGRLLAFARAAGNPDVAPLLCFNNLDRHDWLTGTAELGDFARAWLDRQPDAHLQVRDLLGLDPLRPLWRQPLTAKELLTTGLHVGLQPYQIQVLELTRVAA
>NC_021191.1|WP_015621783.1|4418170_4418731_-|TetR/AcrR-family-transcriptional-regulator
MARAGLTTERLVRAGAELADEVGFAGVTVSALARQFDVKVASLYSHVQSSQDLRTRIALLALAELADLVTDALAGRSGKDALVALANVYRDYAREHPGRYAAAHLPLDDETAAASAGPQHARMTRALLRGYHLTEPDATHAVRLLGAVFHGYVTLESEGGFSHSKPSSDESWTWALDALDTLLRRA
>NC_021191.1|WP_041832341.1|4416681_4417953_-|lipase
MISVPLTADLLRGACELERTERGLLPHRLPAWARAQTPDPQLAMMEAQPSGVRLTLRTRATTIELDTLPTRLVYPGFPPRPEGVYDVLINGVLAARSTADGGNTITVTMSDGTTSFAHGEVATLRFDLPEMPDASTAGPRNGRPGAASSRPHDDRPRASTGGRPVSPGVGAGRDRIVEIWLPHNERTELVALRADAPVEPAPPSGRPVWLHHGSSISHGSNAATPSGTWPALAATQAGVELINLGLGGSALLDPFIARFIRDSHVDVISIKMGINIVNADAMQVRTFGPAVHGFIDTIRDGHPDTPLMFVSPIFCPIHEDTPGPGAFDLEALREGKVAFRATGRPGPGKLTLRVIRDELARIVGQRSAEDKNLHYLDGLALYGEADADELPLPDRLHPDAATHRLIGTRFADLGLHPLLSHPA
>NC_021191.1|WP_015621781.1|4414291_4415791_+|MFS-transporter
MTQTVGQAGSPGTTSGAERPSGGGMLVLYLSLGGLAFAVLQSLVAPALGTIGRELKADTSDASWVITAYLLSASVLTPILGRLGDMAGKRKVLIGVLVTLAAGTAVAALAPNLAVLIVARALQGAAGAILPLSIGIVRDELPRERVATTVGLLSAIFGVGAGVGIVAAGPIVEHLSWHWLFWLPLVLVIVALLGVILGMKESPVRTPGRLDLAGTAILSVSLVSLLLAISKGQTWGWGDAKTVVLLAVGVVTLVTFVLVELRVREPLIDMRLMKIRGVWATDLVALILGFAMFGTFLLVPTLLQLPAATGYGFGKSVSQSGLFLLPTVVMMVLFGPIAGILTKKFGPKLPMFLGAIFVVAAFTLPALSHGEIWQVLASGVLTGAGIGFAFAAMSNAIIESVPATQTGEATSVNTIARTIGSSIGTAVVAAVITSHTTAQGLPTDDAFTYGFWACAGVAVLAIVAALILPSAHRRHEEAVAHGVADLPPEPAELHLPHRN
>NC_021191.1|WP_084504184.1|4412299_4414033_+|flippase-like-domain-containing-protein
MTAPTPVVAIPRPRVAPDGGQRPSRGAAVWKALRELLLVTVLFLAYKAGRVFTAGHTREAMVNAGDVWHFERLVHLPNEVIVQHALLVHHWIVIAANSYYAYVHFPATAATLIYLYARRPGLYLRTRRVLAVLTATALVVHVLFPLAPPRLATGSGLLDTGTLYGPGVYGPPDTDTLSNQYAAMPSLHVGWAVVVAVALASASRGRWRWLWLAHPVLTLTVVVGTGNHYWLDAIVVLILLFVVAVFLVPPVRRAVRSAGAWLRRRWVRVLAWTAAIVAMVAALRGRLPDPAAVVSALGDADPRWLAVAVLAQLCSQAAFAKQQRTLLSALAVALSRRAALAITYTRSAMSLVLPAGSAMSAAFAVRQYRRYGATTAVAATGMVLSAVASVVGLSLLYLGVVSAWALVALAGAGVLGCALFLRRRRLPHPGAAREAFRSRWHWVDRAFDGVRRIGREARAVRLRHWAVTIAFAMLNWLLDLVCLIAVARACGLSLSVPPIATVYLAAQIVRQIPLTPGGVGLIEASLLTGLVAAGAPQATAAAVVLGYRIVSFWLLLPAGLAAYLRLSRFDRTAPAEA
>NC_021191.1|WP_015621792.1|4427832_4428312_+|SRPBCC-family-protein
MNPTPTGRLSGNDLVLTRTFRAPIGAVWASITESDRTARWFGPWQGEAAPGGAIKVQMVLEQGEPWIDMVIAACEPPRRLVVSAGAGAESWHLELMLTETAGVTELRFIQHLTGTENVGEVGPGWEFYLDALVAARENRPAPVFDDYYPAQKSHFEAQR
>NC_021191.1|WP_157408812.1|4428378_4429593_-|pectate-lyase
MAAAAAGVPAIVRQTLAPNDGWASAGTGTTGGAAADAGHVYLVRNRTDLLAALDNGSTVPKIVLVSGRIDMMTGSCADYAAPGYDLDAFLAAYDPAVWGRTTRPAGPLEDARVASARLQGAQIRIPVGSNTTLIGVNGGRIDHGSVTLTNVSNVIVRNLELTDAADCFPAWDPTDGTTGNWNSLYDLVSLSGATNVWIDHNTLSDGNNHDSDQPLHFDRPYQVHDGASDIIRGSDLVTVSWNNYYDHDKTMLIGSTDTPGVDVGKLRVTVHHNKFGNVLQRAPRVRFGQVDVFDNLYVATDADYSYSLGVGVESSICAQNNFFQLSEDLAPAGVLKDWKGTRITTIGNLVRSGSRPPRPVDLVTEYNATHDPDFTPDAGWVPTLRRHVDPAAAVPALVTTAGRH
>NC_021191.1|WP_015621794.1|4430238_4430784_-|VCBS-repeat-containing-protein
MYRKIVTALALASLAGAFATATPAAAYTPGYTFAGVADWDRDGHQDIIARDSTGLLWLYPGQSVRGYSSAARVQIGNGWGPFTVAGVADWDRDGNQDIIARDSSGLLWLYPGQSVRGYSSAARVQIGNGWGPFTVAGAADWDRDGHQDIIARDGNGLLWLYPGQSVRGYSSAYPVQIGNGW
>NC_021191.1|WP_157408410.1|4431004_4434136_+|tetratricopeptide-repeat-protein
MASAVSAGMWSNSPPGPATVESGGSVLVFRLLGSLEVRDPGGALVPVGRRKQRALLAMLVLRAGSVVRVDEMIEALWDGRPPSSARANLHSYVSSLRQVLDRVTPDGPARPLKVPGGYRLDLAPGECDVGVFETLAAEGRRALDEWRHLQAAERLARALGLWRGPLLEDLADFDWLAPYATRLDEARLAALEDQVEARLALGEHAGLAVELAALTTGHPLRERFWGQYIRALHRSGARARALGAYDDLRHVLRSELGVEPSAALQELHRGLLDDVLAPGPADVPAAVPQAGVTPALLPPAVPDFTGRREEVRLLRKVLTPSAQPIGLTVAGVTGMAGIGKTTLAVHVAHSIAGAYPDGQMYANLAGTDATPPDPTEVLGRFLRALGVPSQAVPADAVERAELYRTLLAGRRMLVVLDNAATERQVRPLLPGTPACTVLVTSRSRLSGIEGARWTELDVLPGDEGVRLLSRVVADARIEEQPGDAAAIVDRCGGLPLAVRIAGARLTSRPGWTLAQLASQLRDEQRRLDRLGIGDLQVRASLALSYEALDEPARRLFRRLGLFDVPDFPDWLATVLADDPRTAGRDLDRLVDAHMLTMAGTDAAGQLRYRFHDLVRLFAREQTPRDEADDVLGRGFGAWLAVAEQLEPRLPGPCFAPIAGRAPRPAVPDIVADLVGLDPLTWFDAEQATLRAAIRQACAAGHDEVAFDLAQRMEKYFDVRGLQADWAATNRLALAACQAAGNVRGEAVMLRGLIDVTTWIETDHTGAAMTRALTEAARLQELFRSVGELGGMADAAVMRSWSLTAMGRHAAAIDAATESLGWADTAGHLGGQARAHVALAVALGESGRLPEAVGHLFQALSCARELGNPRYEATVLQFLGMGHSEAGQFDVAEGFLTESLAITRRHGDVYTEVLSMITMARLHLRRGDNQAHPIAVAALALSREYRMTHHTADALGVLGEIELAAGRPAEAAVHLRESVALWRTRGWLSFHAAALVLLGRALADTDPQAAGAAVREASGLFRQAGDTARAEDADAVLAALHKTV
>NC_021191.1|WP_015621796.1|4434277_4434898_+|hypothetical-protein
MIRTATVLALVLTAAAGCGSDPEPAAVAPPSAPVPATPAPTYAQPPGRTCAEIGAALSGLMKVTWKVEASPLGPDSAAAAPGTRQCQAAAASTDHSPPALLSVTLFRPRPRPGTDTPERMLAAVQRRGEDEKCTTQLADPPDGTGYATSCVQSRAATITSASTTLLLESGWVTVTVTAQHQAGDRTARAFVSTSSQDGARSAISMI
>NC_021191.1|WP_015621797.1|4434907_4435768_-|SMP-30/gluconolactonase/LRE-family-protein
MTDVDVLTPDRFELGEGSRWTGDRLVLVDIPHGRLLCAPTGDLRSGLTELARLDVPLAAVAPVAGRPGTFLAAAGTGFALITPDGVQPLAAPEPVTDRPWRMNDAVADRAGRFWAGSMACDQSPGQGALYRLDPGGGVHTVLRDLTIANGPAFSPDGRTMYLSDTPLGHIDRFAVDPATGELSDRRPFARLDPAAGAPDGLTVDSDGFVWAALFGGGAVQRFRPDGTPDRRIELPARQPTSVCLVDRTLIVTSGRGGLDDPGPADGAVLITDAAAAGLPALAARMA
>NC_021191.1|WP_015621798.1|4435796_4437005_-|low-temperature-requirement-protein-A
MADQQQLDEQEADQVDPVRPPDLNQDANRSATRLELFFDLAFVLFIARCADLLAGDETWHGAVLFAAVLTVGWWSWASTTLYANRFDTDDTVFRLLTLTAMAAVVVMAAAVDKVSAPSGRWFVLGYVVIRLVLATGYLRAWRHVENARPVIMPYLIGHATGAVVWLVSLAVPTPGRYVLWGVGILLDLIGPAVAARVEHAVPLHLEHLPERFGLFVILVLGESIAAIVTGLHDGGWKHEVVLVAAPAFVVAVALWWVYFDLSGGAAKRRLVEEGGDRTHQGVHDFYLYAHLPIAVSLAAVAVGLEHGVLHGSDDHLTAGTRGVLGIGVAGYLLSTALLQGVLGRRVRGALLWPGLGVPLALLIVALDLSPVLTLMLLALLSAAGVVTGFLLHRAGEVRTAQV
>NC_021191.1|WP_157408411.1|4437051_4437405_-|hypothetical-protein
MIEDPARPSPLSGLWTAVAGAPVYVLLLLVAHPITRVEDCSNYGAAGNASAFANSSWDLWLPLIALGWLLVVLIEQALPVTWRHRGGGEVAVRALTALVGSLAWSCCLTLPFLGMCH
>NC_021191.1|WP_015621800.1|4437442_4438210_-|hypothetical-protein
MNIVADMLLREPAPAAIWAALMLLALPALVLLASPIGLRRPRAAFLGTARAVTALREQRHRRVREAEEIIRYAAELHAAAERAEAGARRWQEHRQDAEQLVEDTWQAWQAAQARLERVRGAAAFRNPYTVPSPAEYAARERWLHQAVRAAAERGDLPATAVADALAGRGWDATLHPFEQELAVLRAVAEHHRARHHHAVATEQNAWHDAHLARRTADDLRREAANATVEATAAARLLPSGGGARRARAAVAVRTA
>NC_021191.1|WP_041832344.1|4438559_4439165_-|hypothetical-protein
MATVLVRGVLQRTMPALLALLVSGLGLTGAAGHAAPMPGAGTLPGAAAVPAATSAAAATTSAAAGAHLRAVPLAATVPLASAVSLASAVSLTGAAPLTSTAAFATTAALHGTAALAGPAALAGTAALAGTAPFPGAGVSSDAGPDCAHVAGTTTGSGAAPAPAQLPAPRAGTAAIPALDQAGPTARTAGVHGCRAPPRLSA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_11

4464191-4464288

Orphan

Consensus_repeat	Method
CGCCAAGCTCTGAGAAACGGGCGCCCGGGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_11

>merge|NC_021191|11|4464191-4464288|CRISPRCasFinder
CGCCAAGCTCTGAGAAACGGGCGCCCGGGAGGACCCGGACACCCCGCGAGGCTGACGCTGGGACGAGCGCCAAGCTCTGAGAAACGGGCGCCCGGGAG

>NC_021191|11|11|4464191-4464288|CRISPRCasFinder
CGCCAAGCTCTGAGAAACGGGCGCCCGGGAG	GACCCGGACACCCCGCGAGGCTGACGCTGGGACGAG
CGCCAAGCTCTGAGAAACGGGCGCCCGGGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_157408414.1\|4465914_4466418_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_157408412.1\|4453476_4454505_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_021191.1\|WP_015621815.1\|4452796_4453417_-\|DUF4232-domain-containing-protein	unknown	unknown	gnl\|CDD\|379419
NC_021191.1\|WP_157408413.1\|4455396_4456929_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226359
NC_021191.1\|WP_015621830.1\|4469927_4472195_+\|catalase	unknown	unknown	gnl\|CDD\|236886
NC_021191.1\|WP_015621823.1\|4460648_4460906_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_041832351.1\|4473476_4474202_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|237218
NC_021191.1\|WP_015621820.1\|4457818_4458715_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224098
NC_021191.1\|WP_015621819.1\|4456925_4457819_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224097
NC_021191.1\|WP_015621833.1\|4474241_4475447_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NC_021191.1\|WP_015621821.1\|4458711_4459920_+\|D-galactonate-dehydratase-family-protein	unknown	unknown	gnl\|CDD\|237901
NC_021191.1\|WP_157408415.1\|4475443_4475671_+\|ferredoxin	unknown	unknown	gnl\|CDD\|379145
NC_021191.1\|WP_157408814.1\|4464415_4465369_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	unknown
NC_021191.1\|WP_041833727.1\|4459931_4460357_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_041832350.1\|4466507_4468763_-\|DUF1906-domain-containing-protein	unknown	unknown	gnl\|CDD\|119380
NC_021191.1\|WP_015621828.1\|4468934_4469840_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015621824.1\|4460928_4462743_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NC_021191.1\|WP_015621835.1\|4475758_4478278_+\|secreted-arabinosidase	unknown	unknown	gnl\|CDD\|226064
NC_021191.1\|WP_015621817.1\|4454518_4455730_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|226618
NC_021191.1\|WP_015621831.1\|4472339_4473443_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_041832350.1\|4466507_4468763_-\|DUF1906-domain-containing-protein	gnl\|CDD\|119380	cd06418, GH25_BacA-like, BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of Bacillus subtilis. BacA has a C-terminal catalytic glycosyl hydrolase family 25 (GH25) domain and an N-terminal peptidoglycan-binding domain comprised of three alpha helices which is similar to a domain found in matrixins.	1.21634e-54
NC_021191.1\|WP_157408412.1\|4453476_4454505_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.93001e-100
NC_021191.1\|WP_015621815.1\|4452796_4453417_-\|DUF4232-domain-containing-protein	gnl\|CDD\|379419	pfam14016, DUF4232, Protein of unknown function (DUF4232). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	5.06947e-05
NC_021191.1\|WP_157408413.1\|4455396_4456929_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226359	COG3839, MalK, ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism].	1.25412e-136
NC_021191.1\|WP_015621830.1\|4469927_4472195_+\|catalase	gnl\|CDD\|236886	PRK11249, katE, hydroperoxidase II; Provisional.	0
NC_021191.1\|WP_041832351.1\|4473476_4474202_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|237218	PRK12825, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	3.59141e-55
NC_021191.1\|WP_015621820.1\|4457818_4458715_+\|ABC-transporter-permease	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	4.71468e-51
NC_021191.1\|WP_015621819.1\|4456925_4457819_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	1.33663e-35
NC_021191.1\|WP_015621833.1\|4474241_4475447_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	3.06468e-90
NC_021191.1\|WP_015621821.1\|4458711_4459920_+\|D-galactonate-dehydratase-family-protein	gnl\|CDD\|237901	PRK15072, PRK15072, D-galactonate dehydratase family protein.	0
NC_021191.1\|WP_157408415.1\|4475443_4475671_+\|ferredoxin	gnl\|CDD\|379145	pfam13370, Fer4_13, 4Fe-4S single cluster domain of Ferredoxin I. Fer4_13 is a ferredoxin I from sulfate-reducing bacteria. Chemical sequence analysis suggests that this characteristic [4Fe-4S] cluster sulfur environment is widely distributed among ferredoxins.	1.33548e-07
NC_021191.1\|WP_015621835.1\|4475758_4478278_+\|secreted-arabinosidase	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	1.52568e-33
NC_021191.1\|WP_015621824.1\|4460928_4462743_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	2.43972e-151
NC_021191.1\|WP_015621817.1\|4454518_4455730_+\|extracellular-solute-binding-protein	gnl\|CDD\|226618	COG4134, COG4134, ABC-type uncharacterized transport system, periplasmic component [General function prediction only].	1.19757e-56
NC_021191.1\|WP_015621831.1\|4472339_4473443_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	8.21783e-53

>NC_021191.1|WP_015621824.1|4460928_4462743_+|DEAD/DEAH-box-helicase
MTEHPVDEEPAGFAGLALRPELLTALGNLGYEEPTPIQREAIPPLLAGHDVLGQAATGTGKTAAFALPLLHTLAADLAGDGNEPAGAVRAGGERGRATDDGGQRPGTAGDGGDRARDAGPGALVLVPTRELAEQVSQAVHRYGRGLGVRVLPVYGGQPIGRQLHALKRGVDVVVGTPGRVLDHLSRGTLDLTGIRTVVLDEADEMLDMGFAEDIEAILDETPGERQTVLFSATMPPRIDAIARQHLREPVRIQMGRPALPPGELPRVRQSVYFVARAHKAAALGRVLDVEAPTAAIVFCRTREEVDELTEVLNGRGYRAEALHGGLSQDQRDRVMGRLRNGTTELLVATDVAARGLDIEQLTHVVNYNVPSAPEAYVHRIGRVGRAGREGSAITLAEPREQRMLTAIERLTRQPIAVEAVPSVSDLRARRLELTRASIEERLGDDDLDRFRGILDRLTEDSDLETVTLAAIKMLHEAAGGNGDDVEIPSVARVPRDKPRDKFRRDDSRTNDRTGRPVRGKPASAGSARLFLGIGKRAGLRPQDMVGAIAGESGLNARDIGAIQIQDRYTLVEVPEPAADMVIAALRRATIRGRKATVRRERPLS
>NC_021191.1|WP_015621823.1|4460648_4460906_+|hypothetical-protein
MTDLEEAVELEAGPELIATHYLTSIEDAVEHLRAASQLGLGVRLRTYLEPEDDGETLAERWELELLTSSPVHHDDAAPHEDAAAE
>NC_021191.1|WP_041833727.1|4459931_4460357_-|hypothetical-protein
MSEWAEPDSVLATYVSLMDQLIERADPGVPLSLTVGGLQVDGELIPQWQWFAEVSELNNYEDAFYTGMAEFVKEQSDLAHQAVKVRDAGLEVTHKQHLALSEPTRYIHLRNARINGVADTGLWRGRLKDISGWTPGSAKNS
>NC_021191.1|WP_015621821.1|4458711_4459920_+|D-galactonate-dehydratase-family-protein
MIITEARVVVCCPDRNFVTLKLVTDEGVTGVGDATLNGRELAVAAYLTEHVVPTLIGRDPARIEDTWQYLYKGAYWRRGPVTMSAIAAVDTALWDIKGKVAGLPVYQLLGGRSRSAVTVYGHASGTDIDAALADVARLVDLGYRAVRVQTAIPGLGSTYGVGKGGPTYEPADAAVPTENVWSTPLYLAHVPKVFAAVRDEFGPALRLLHDVHHRLTPIEAARLGRSLEPYQLTWMEDPVPAELQSGFRHIRHHTTTPIAVGEVFNSVWDCQQLITEQLIDYIRATVVHAGGITHLRRIFDLAALYHVRSGSHGATDLSPVCLSAALHLDVSIPNFGLQEYMSHTPLTDRVFPHGYRFDDGCLHPSEEPGLGVDIDEELAAQYPYRAASLPVNRLEDGTMHSW
>NC_021191.1|WP_015621820.1|4457818_4458715_+|ABC-transporter-permease
MARAEVAVAQAGKGAPGGNGPRARKVVASPAAWLVWGAVTIFFIGLAGVVGSVVVNSFGTRWFDTWLPQGWTNDWYGQAWDEFTLLPVLGVTLTVCLLVTAVSVLVGVPASYVLARRSFPGRRAVYLMFLLPILMPPITYGIPLATVLYKYGLAGHLSGVVLANLVPSIPFVILTMTPFIEQIDPAVERAARMCGARTAQIFLRILAPLLIPGILAASILVVVRTVGMFELTFLTAGPDSQTLVVALFYSMSASGIRAQQSVDAMAVIYTLMMLILLVVALRFVNPTQLVARVKEDVE
>NC_021191.1|WP_015621819.1|4456925_4457819_+|ABC-transporter-permease-subunit
MTVVPARVALRHRLADRGVDMQLLLLVPATLFIAALFIYPFCYGLGLSLQPAQGTVFSAYQQFFTDAYQRDTILTTLRIALPAALLNVVASVPIAYRMRGRFRGKRLLTTILVVPITLGTVLTAEGLLGFLGPTGWLNRTLIDARLIDQPLTLTHNYWGVFLSLVITGFPFAFLLVLSYLSGIDPSLERAAATLGAGWAPRFFRITLPLLAPGLATTFCLTFVLAFSVFPSAILVGDPSGSTRVISIAAYEAAYVRYDYAGASAAALIMGAVELVVIAVVLGLRSLLYTGTTSGGKG
>NC_021191.1|WP_157408413.1|4455396_4456929_+|ATP-binding-cassette-domain-containing-protein
MDYRRALRGRAEGRLDRQAGRRSPADRVDVDAPAASQGVRQGVLLPGAGDQGRHAGDGARGQPQGHRGVRPSRVRGPDRPEPARSPVGRHVAGRRVRPVGPRGRRQQGEEVSEFQQLRLDGVTRRFGGTDALAGLSLTIRRGEFIALLGPSGCGKSTALNCLAGLLPLSSGSIWRDDVRLDTLPAERRGFGMVFQNYALFPHMSVRGNIAFGLRMRRLPRAEVTRRTDEAIRLVRLAEHAGKLPGQLSGGQQQRVAIARAVVLEPALVLMDEPLSNLDAKLRLEMRTEIRRLHQSLGLTTVYVTHDQEEALSLADRLVVLRDGRVQQIGTPEEVHTQPANRHVADFMGYRNMLPMVFADGFVEGCGLRLRGTAAGELHNGDAVEAAIRPEDIQVLDRAAPGSAGAGAGVEVTVEVVEYQGREVAAEVRTSDGTLLHVRTGQRLAPGDKIRVTFSSSRLLLFPEVDGGGPRAGDGGPRAGDGGPRAGDGGTLEDGGASVVESTPRSEGGAA
>NC_021191.1|WP_015621817.1|4454518_4455730_+|extracellular-solute-binding-protein
MSSTRRQFLVMTAGAALTAAACSAPDSGGGTGSTSGPVPDKPSAPQTVNVLDVAGNLQLTQGMIDEFVSGHPDVISKVTYTKATAPELVGKVKAQQAANRVDIDLVLTGVDGLAAGIGQGLWIDLLPAYANRVPGMGNYLPGAQAMQKLAGNSGITVTYYPSGPLIEYLPKSVAAPPASAEALLEWAKQNSGGFQYARPSNSGPGRTFLMGLPYLLGDSDPRDPANGWAKTWAYLKELDQHVALYPSTTSETMKNLANGSAKIIASTTGWDINPRVLGTVPKEAKIGTLRGFRWITDAHYAVVPKGVSTDKQAAVLLLIASMLTPQQQAKAYDKGYFYPGPAIKDVTLAMAPEDSRKAIEEFGRPEYEALIAQNPLEVPLDATSLVAAFDRWDREVGGNKVKK
>NC_021191.1|WP_157408412.1|4453476_4454505_+|LacI-family-DNA-binding-transcriptional-regulator
MSIDGRIGVSVTVTIRDVARRAGVSPSSVCRALADPAAVRADTRERVQQAVQELGYYPNRAARGLSTGRTGNLGVVLPDLGNPFFPAVVKAVQSQARACDYAVFLSDIDEEPAAEAQLIRAMAKQVDGFLLCSPRSADEELRSFAGQVPIVVLNRRIAPFPSVTADNPDGMRQAVAHLHALGHRRIGYVSGPRASWSNRERWRGLRTSAGVLGGIELVEAGSVPPTVDGGIAIADVVLAAGVTAVLAYNDLTALGLLHRFQARGVAVPEDISVVGFDGIMLSALVSPALTTVAVAAEQIGRVGVDLLLETMADPERSPVRRVLPAQLIVRSSTGPVKAGRTR
>NC_021191.1|WP_015621815.1|4452796_4453417_-|DUF4232-domain-containing-protein
MARNREHSAPRSSYLDPYGRRHGGTADDEGDETMRGPVLAVTAGIVLAAAAAVTTAAHASTVPGACGAGDLTTTVDESDMYSKGGHYFENLDVTLTNMTDTACVLEGTPAVALTGPATGSFAHSYQLPQTGTTPLLTLSRGTEARVTVRVHVLPEAQDVWQPQRMLITLPGSAETVTVAWPDGLTIQQESKPLPGLGAPNAVEAGA
>NC_021191.1|WP_157408814.1|4464415_4465369_-|LPXTG-cell-wall-anchor-domain-containing-protein
MAGAGAVKGTQGTLALEPGSPRLRSSPAVTEAGITTAVLTGGGTATGLPANPPVDPNTAQLAAVTEKGPETYQTKVGKLGPDTDFPGTVAVRNDGGKTVDGLVLELRLSDNDLSFTTRSSNCWYALEDKPDSAWCAFDDTLAADAVKKLATPIATTGATGREEIFKDVRFHWTTKAWADEHGGIQALTQLAATPGTSAVRGTGPALELATVAPGTALAGHLAGSTDFLLAVWAPGAGPSPSPTPAATPTTTKPATGGGTGDGSTGDGSSDGQAGGDGGGLPVTGTKTALVAGIGLALLLAGGAGLLVARRRKTRFLA
>NC_021191.1|WP_157408414.1|4465914_4466418_-|hypothetical-protein
MRRRTVLLLGAGAGAATVLPLSVPASAAPQLREYPIQGSDATVRLLPGPAATLLLYAARRFHYEVDTLHPGEVVASADGTTLDLRPHWYAVGVSGGLLPYQVAVVRDILAGSGGMLAWGGDDAGQPREGRFRLTVAPANARLRTHARRLDGFERKRSQRIGAHRTAG
>NC_021191.1|WP_041832350.1|4466507_4468763_-|DUF1906-domain-containing-protein
MSAEVLAVQRWVNATYRTVSGYTPVTEDGITGSQTTGALTRALQHELGLTSLADNFGTGTLAALTNHGPVSAGEANHNIVFIVQGGAICKGYDPGTLDGVWGTRTTTAITAMMTDAGLATTDGTLQPKVFKALLSTDSYLLAAGGSAAVRAAQQWLNNRYLNRSAFFVLPCDGVGTPAILKALTFGIQYEAGLDDATANGNFGPLTQSSLRSRGLIQTGSTGAWVRLFSGALALYPSAQTFTDTFDATLAGQVRAFQRFVALAETGAGDFATWAALLISTGDPARPATAADTITEVTAARATALTNAGYSLVGRYLTNVEGSDFDKKLKPGEPATLFANGMRLFPIFQTANDSAEFFTYQQGYDDALAAHDAALGFNLDAGATIYFAVDFDATDKNVDERIVPYFLGVAAGLRARGNRYAHGNYGARNVCTRLFREAYTLRGFVSGITTGWTANVGYPLPDNWLLDQFATVTVGSGAASLEVDRCVLRPYGDQGEGATGSPAATLDQFLAWIDRLSALATAYGQGDPDRLVLQYLRAGRHDTWQSRQLNGDTDAGFAAYVGAAGGARIRTYRDPVANVDVDASRFADATLGALQSGIRADFGSWGQDWVALYGDWQFTAPGTPGKDRASTMFAKSSVVSAFTLAAMVADVDAYHAAAALTAGTRLAAHLRGTARTSRFRRFFQTRFGGSAALAATAARDVLTSTADAQVAAARDRMLRGQATTPVPASDQMTAFCQVFADRLVALAWAEAK
>NC_021191.1|WP_015621828.1|4468934_4469840_+|hypothetical-protein
MDATVTIAVLLGVVSALGYAAGALLQQRVGDRPVPQLLRLPRWWLAIGSNGLGALLHVAALRFGSLVLVQALGVLTLVLAVPLAAAVGRRRVGRREAAGTGLAAAGLAGLLLLTGSAAASALTSHELVVLVLAAALVLTVAAGRAHGLTAAAAGGLAFGVASAITQTLTVRMTDGLPFVAPAVVAVAALNVAGVLLTQRSYRRGLAGPLAVGTVANPVAAAVIGVVLLGERVRGGTTGIALALLCAAVIAAGVQLLTARRDLHTRARSAHLVRSRPVRRHRRAVTRPAGRGRPVPVPLMPR
>NC_021191.1|WP_015621830.1|4469927_4472195_+|catalase
MDASKPAKAVKNAVESATAKVADALTPDRVPGSPGSAPAPLEEPTTPHDPLPPKDEQGTPATVTPTGAETGVPPIKKGQQGAYLTTSQGARLRDTDHSLKAGPRGPILLQDHHFREKITHFDHERIPERVVHARGTGAHGVFTAYGTAGSVTRAGFLKKGTETPVFVRFSTVLGSRGSADTVRDTRGFATKFYTDEGTFDLVGNNIPVFFIQDAIKFPDVIHAGKPHPDREIPQAQSAHDTFWDFVSLHTEAQHHTIWNMSDRGIPRSYRTMEGFGVHTFRMVNDAGETSLVKFHWKPKLGVHSLDWEEAQLLAGVDPDFHRRDLYDAIEAGAFPEWELGIQVFPDTAEETFAGIDLLDPTKIVPEELAPVQAIGKLVLNRTPTNFFAETEQVAFHLGHLPPGIDVTNDPLLQGRLFSYVDTQLTRLGGPNFSQIPINRPHADVNDMLRDGFHQHAVHAGVAPYRPNSLDGGNPFPAGDKENAFLDVPVVVAEAPKVRANPASFEDHYSQVRLFWLSMSPVEREHIIRAYTFELAKCYEQAIKERQLQCLANIDPVLCEQVATGLGLPAPQPTVPLAEVEASPALSQVRGEWPADGRMIGIVVDAAAGDLDGVHEVRRAIFDAGMVPLLIAAHGGMLGDLPVQRTFATARSVEYDAILLAGAPAPAPDAIGARDAKAGASGPAPVDPRVLLLVEEAWRHAKAVGAWGAGTTVLDLAGVRGTPGVVTAATGAEALTALQALLPAHRVWERFPATVA
>NC_021191.1|WP_015621831.1|4472339_4473443_-|AI-2E-family-transporter
MAGTLNPAKTRAALRTTARFSLEMLLVLLMTAVTLWLLGRAWSILWPLVVALLLTTLTWPPTRLLRRLGWRPALAASTVTLLFLVVAVGIVVLIALPVSNQAPKLASGVVDGIQHLRDWASGPPLNIGDDQVTKALDSATARVQNSVGSIVNYTITGVGTVVNGIVTTVLALFLMFFFLKDGPRFLPWLTRQLPGRFATDVPAVAARGWDTLGAFVRSQAFVGLLDAVFIGLGLWIVGVPLVLPLAVLTFVSAFVPIVGALFAGFVAVLIALVFNSWTDALIVLAIIVAVQQLEGNVFQPMIQSRGLGLHAAVVLLAVTLGGSLAGIVGSLLAVPVAALIAVLWNYVRDQLSDPDPEPAPDPEPATE
>NC_021191.1|WP_041832351.1|4473476_4474202_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSNLAGRRALITGASGGIGGALARSLAAAGADLVLTFAGHAGEAEAAAADARALGRRVEVRRADLSEPGAGRALAAAAGPVDVFVANAGAGVRRDWADVDDPLWSMTFAVNTTAPWETTQALLPGMVERGFGRILYVSSVAALTGGVVGPHYAASKAALHGLLHHLAPRVAPAGVTVNAIAPALISGTRMLPANPGSEPPVAIPVGRLGTPEEIAAMALSMLTNGYLTNKVITVDGGIHPH
>NC_021191.1|WP_015621833.1|4474241_4475447_+|cytochrome-P450
MSNPTQTPIDFPLPKPETIFHPSAELSRLQRTSPVVPFRTADGRTGWLVTRYEDVRQVLVDPRFSRAEAGRPGVPDPGLGQASAESILGMDPPEHTRLRRLVAGAFTARRVEALRPRVTELVHDLIDHLTALDQPADLVENFSLPLPVQVICELLGVPPEDRHMFHAWSDGVLSAADHPERIATAFADLTAYFQKLIALKRKLPADDLMTALIAARDDKDRLSEEELVRLGLTILVAGHETTANQINLFLINLHEYPDQLARLRANPGTIPQAVEELMRFVQLGPGGAGLVRVLKEEMTLSGVRLPAGSAVVPVMSIANRDPLLVSDPDRLDVSRPIGGHLGFGAGVHHCLGAQLARVELQEALHGLLTRLPGLRIDVPPTELRFKDGMILRSLHSLPVRW
>NC_021191.1|WP_157408415.1|4475443_4475671_+|ferredoxin
MTVPRWTVTVGPECIAAGSCLGLAPDRFALGDDGRSHPVRDEVTPDEAVLDAAASCPMEAIAVRDATTGDRIDPL
>NC_021191.1|WP_015621835.1|4475758_4478278_+|secreted-arabinosidase
MSRARKLLGLATTALLAASLPATAAVPARAQEPGYTITVEPGVTGPAIDDAMYGIFLEDINFGADGGLYAELVRNRSFEFLPVDNASYTGMTAWTPVAEAGGSGTATTVNDDARLNERNRTYLKLGLSGTGRYGVTNSGYNTGFAVRRGARYTFSVWARTDDPAGTPLTVTLTGTRTTTLTVRGDSWRKYTATMTAGRTTDTGRLAVLGAGRGTLRLDMVSLFPRDTYRHRPNGLRKDLAEKIAALHPGFVRFPGGCLVNTGSMASYDAASGFPRARAYQWKDTVGPVEARATNANFWGYNQSYGLGYYEYLQFAEDIGAKPVPVVPALVTGCGQNRATDDPALLQRHLQDTLDLIEFANGPVTSTWGRLRARMGHPRPFGLDRIAVGNEENLPEQYFATFLRFRAAIEAKYPDVTVIGNSGPDDQGATFDDLWARNRAAGVDMVDEHYYNSPSWFLQNNKRYDSYDRSGPAVFLGEYASLDNKLANSLSEAAYMTGLERNADVVRMASYAPLLANIDNVQWRPDLIWFDNDESWGSTSYLVQKLFSTNTGDRVVRSAAGGGGVRQPKPITGAIGLSTWATSATYDDVRVTRPDGTVLFSDDFTDGDDSGWTAVQPRGSWSVTGGAYTQGDTAAQDTMVKAATIDETDYDYHVKATKNAGAEGFLIAFGIQETGQFYWWNLGGWNNTQDAIEKGVTSAKEQLITKPGSVRTGRTYDLRVEVRGTHVRLLVDGQEWGSFDDNTVAEPFAEVVTRDDRTRELIVKVVNAQDAPAVTRIDLGGRRVAPTGRMTVIAGDPGEQNTRSAEPVQPVTTTVGGLGQTFTRTFPANSVTFLRVKETH

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_12

4737075-4737264

Orphan

Consensus_repeat	Method
CCGCGCCCAGCCTCTCCCGGTACGACCGCAGGTCCACCGTCGGCGTCTCGTCGCCCTC	PILER-CR

2 spacers

The CRISPR arrays of NC_021191_12

>merge|NC_021191|12|4737075-4737264|PILER-CR
CTCCCGGTACGACCGCAGGTCAACCGTCGGCGGAGCGTCACCCTCAGTCTCTGTCGCGTCCTGCTTCTCCCGGTACGACCGCAAGTCCACCGTCGGCGTCTCGTCGCCGTCCGCCGCGCTCCTGCCTGGTCCCGCGCTCAGGCTCTCCCGGTACGACCGCAGGTCCACCGTCGGCGTCTCATCGACCTCG

>NC_021191|12|1|4737075-4737264|PILER-CR
CTCCCGGTACGACCGCAGGTCAACCGTCGGCGGAGCGTCACCCTCAGTCTCTGTCGCGTCCT	GCTTC
TCCCGGTACGACCGCAAGTCCACCGTCGGCGTCTCGTCGCCGTCCGCCGCGCTCCTGCCTGG	TCCCGCGCTCAGGCTCTCCCGGT
ACGACCGCAGGTCCACCGTCGGCGTCTCATCGACCTCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015622101.1\|4741733_4743155_-\|magnesium-chelatase-chlI-subunit	unknown	unknown	gnl\|CDD\|224160
NC_021191.1\|WP_015622091.1\|4732396_4732861_-\|bifunctional-nuclease-family-protein	unknown	unknown	gnl\|CDD\|376830
NC_021191.1\|WP_041832382.1\|4747369_4748269_+\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|225915
NC_021191.1\|WP_157408828.1\|4735018_4735792_-\|DUF881-domain-containing-protein	unknown	unknown	gnl\|CDD\|377575
NC_021191.1\|WP_015622106.1\|4748250_4749465_-\|glycogen-synthase	unknown	unknown	gnl\|CDD\|273997
NC_021191.1\|WP_015622103.1\|4744068_4745703_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_021191.1\|WP_015622104.1\|4745712_4747347_-\|family-10-glycosylhydrolase	unknown	unknown	gnl\|CDD\|224563
NC_021191.1\|WP_015622102.1\|4743222_4744056_+\|PhzF-family-phenazine-biosynthesis-isomerase	unknown	unknown	gnl\|CDD\|334973
NC_021191.1\|WP_015622100.1\|4739774_4741727_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|227204
NC_021191.1\|WP_015622094.1\|4734609_4734990_-\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NC_021191.1\|WP_015622098.1\|4738891_4739509_-\|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|223632
NC_021191.1\|WP_041832383.1\|4749525_4750758_+\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234846
NC_021191.1\|WP_015622093.1\|4733938_4734391_-\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NC_021191.1\|WP_015622108.1\|4750918_4751404_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176862
NC_021191.1\|WP_015622088.1\|4730940_4731480_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|226489
NC_021191.1\|WP_015622087.1\|4728675_4730253_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NC_021191.1\|WP_015622090.1\|4731576_4732140_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133380
NC_021191.1\|WP_041832381.1\|4733195_4733876_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
NC_021191.1\|WP_015622096.1\|4735824_4736157_-\|small-basic-family-protein	unknown	unknown	gnl\|CDD\|377739
NC_021191.1\|WP_015622089.1\|4730262_4730868_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015622101.1\|4741733_4743155_-\|magnesium-chelatase-chlI-subunit	gnl\|CDD\|224160	COG1239, ChlI, Mg-chelatase subunit ChlI [Coenzyme metabolism].	5.27013e-82
NC_021191.1\|WP_015622091.1\|4732396_4732861_-\|bifunctional-nuclease-family-protein	gnl\|CDD\|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	5.06123e-58
NC_021191.1\|WP_041832382.1\|4747369_4748269_+\|NAD(P)-binding-protein	gnl\|CDD\|225915	COG3380, COG3380, Predicted NAD/FAD-dependent oxidoreductase [General function prediction only].	6.51325e-45
NC_021191.1\|WP_157408828.1\|4735018_4735792_-\|DUF881-domain-containing-protein	gnl\|CDD\|377575	pfam05949, DUF881, Bacterial protein of unknown function (DUF881). This family consists of a series of hypothetical bacterial proteins. One of the family members YlxW from Bacillus subtilis is thought to be involved in cell division and sporulation.	5.58455e-28
NC_021191.1\|WP_015622106.1\|4748250_4749465_-\|glycogen-synthase	gnl\|CDD\|273997	TIGR02149, glgA_Coryne, glycogen synthase, Corynebacterium family. This model describes Corynebacterium glutamicum GlgA and closely related proteins in several other species. This enzyme is required for glycogen biosynthesis and appears to replace the distantly related TIGR02095 family of ADP-glucose type glycogen synthase in Corynebacterium glutamicum, Mycobacterium tuberculosis, Bifidobacterium longum, and Streptomyces coelicolor. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_021191.1\|WP_015622103.1\|4744068_4745703_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.84691e-133
NC_021191.1\|WP_015622104.1\|4745712_4747347_-\|family-10-glycosylhydrolase	gnl\|CDD\|224563	COG1649, COG1649, Uncharacterized protein conserved in bacteria [Function unknown].	5.27295e-85
NC_021191.1\|WP_015622102.1\|4743222_4744056_+\|PhzF-family-phenazine-biosynthesis-isomerase	gnl\|CDD\|334973	pfam02567, PhzC-PhzF, Phenazine biosynthesis-like protein. PhzC/PhzF is involved in dimerization of two 2,3-dihydro-3-oxo-anthranilic acid molecules to create PCA by P. fluorescens. This family also contains uncharacterized Mycobacterial proteins, though there is no significant sequence similarity to pfam00303 members. This family appears to be distantly related to pfam01678, including containing a weak internal duplication. However members of this family do not contain the conserved cysteines that are hypothesized to be active site residues (Bateman A pers obs).	2.53818e-71
NC_021191.1\|WP_015622100.1\|4739774_4741727_-\|VWA-domain-containing-protein	gnl\|CDD\|227204	COG4867, COG4867, Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only].	0
NC_021191.1\|WP_015622094.1\|4734609_4734990_-\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	2.3588e-62
NC_021191.1\|WP_015622098.1\|4738891_4739509_-\|CDP-alcohol-phosphatidyltransferase-family-protein	gnl\|CDD\|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	3.62754e-20
NC_021191.1\|WP_041832383.1\|4749525_4750758_+\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|234846	PRK00844, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NC_021191.1\|WP_015622093.1\|4733938_4734391_-\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	1.80942e-23
NC_021191.1\|WP_015622108.1\|4750918_4751404_+\|SRPBCC-family-protein	gnl\|CDD\|176862	cd07820, SRPBCC_3, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	1.35438e-40
NC_021191.1\|WP_015622088.1\|4730940_4731480_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|226489	COG3981, COG3981, Predicted acetyltransferase [General function prediction only].	2.74708e-45
NC_021191.1\|WP_015622087.1\|4728675_4730253_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	9.9269e-42
NC_021191.1\|WP_015622090.1\|4731576_4732140_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133380	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators. Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	8.33286e-21
NC_021191.1\|WP_041832381.1\|4733195_4733876_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.73688e-16
NC_021191.1\|WP_015622096.1\|4735824_4736157_-\|small-basic-family-protein	gnl\|CDD\|377739	pfam06947, DUF1290, Protein of unknown function (DUF1290). This family consists of several bacterial small basic proteins of around 100 residues in length. The function of this family is unknown.	2.49836e-35
NC_021191.1\|WP_015622089.1\|4730262_4730868_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.45277e-19

>NC_021191.1|WP_015622096.1|4735824_4736157_-|small-basic-family-protein
MIPVVALIAGVVLGIVFHPTVPPALQPYLPIAVVAALDAVFGGVRAKLDGIFDDKQFVVSFIANVVVAGLIVYLGDQLGVGGQLSTGVVVVLGVRIFGNVAAIRRHLFRA
>NC_021191.1|WP_157408828.1|4735018_4735792_-|DUF881-domain-containing-protein
MAGETPVTGEEPVAGEDAATEEKPGKRRISSAGALIGLLLALFGFTLVVQLRSNDADSGLAATRQEDLVRILSDLDARDQRLQQEITGLEESQRQLTSGVAGQQAAQAEAEKRGDELGLLAGTLPAHGPGLKIDIDPKGQPIKASAILNAVQELRGSGGEVMELVGDNGVAVRLVASSSFVDAEGGEIIVDGKQLTGPYTLWVIGVPATMQTALQIPGGVVASVSQDGGNVTMEQRSTVEVTAVRQPPSLQYARPVS
>NC_021191.1|WP_015622094.1|4734609_4734990_-|glycine-cleavage-system-protein-GcvH
MIPEDLRYTAEHEWVSGDGTGPVRVGITHFAQDALGDIVYVQLPDEGTAVQAGDQLGEIESTKSVSEIYAPVAGTVVARNATLGDEPELINAEPYAAGWLVEIAPDDPAALDGLLDAAAYQALTEG
>NC_021191.1|WP_015622093.1|4733938_4734391_-|FHA-domain-containing-protein
MTRPDDEFPPLDVTSTLNLGALDEVLEGPETDVVPSRMSGSLPPGMALLVVRRGPNAGARFLLDHDVTTSGRHPDSDIFLDDVTVSRRHAEFHRDGGTFTVRDVGSLNGTYVNRERVESATLSNGDEVQIGKFRLVFIAGPRPEGEGGQA
>NC_021191.1|WP_041832381.1|4733195_4733876_-|MerR-family-transcriptional-regulator
MSIGEVLAQLRTEFPDTTISKLRFLEAEGLVDPQRTASGYRKYSWNDVARLRFVLTAQRDQYLPLRVIREQLEALERGDDPLTRQRPSLVAVGSEPEVAADAADTRVSRADLMERTGAAEHLLTELEQIGLVTSRPPGWYDGDAVVIVEAVVGLQKHGLEVRHLRAFRTGADRELGLFTQLLAPLVRQQDPAARARAAETARELQALSQRLHAALVRAGLRDTLGR
>NC_021191.1|WP_015622091.1|4732396_4732861_-|bifunctional-nuclease-family-protein
MRELSVVGVRVELPSNQPIVLLREVDGDRYLPIWIGAVEATAIAYEQQGVKPARPLTHDLLRDILAALQAPLKAVEITELKENVFYADLLIGDNLRVSARPSDSIALALRVGAPIRCADQVLTEAGIVIPDEQEDEVEKFREFLDQVRPEDFAG
>NC_021191.1|WP_015622090.1|4731576_4732140_-|MerR-family-transcriptional-regulator
MHGSDPQEGPLVGEDGEVGYRGVTACQAVGISYRQLDYWARTTLVVPSIRDASGSGTQRLYSFRDLVVLKVVKRLLDAGVSLQNIRKAIETLRSRGVDDLAGITLISDGTTVYECRSPEEVVDLLQGGQGVFGIAIGGAFKEIQGSLSHLPAEPAAGPQPVGSDNPAPADPAAGDELAARRARRRAG
>NC_021191.1|WP_015622088.1|4730940_4731480_+|GNAT-family-N-acetyltransferase
MPLLNPPTSAVRASFLAAMAEFQAEGRGVPADHSMLGREIRTWSPRWSDPAVFADYVRELRADALEETPRPDTFVPGTSLWWIDGTEYLGRLTVRHRLTAGLLEYGGHIGYDVRPSARRHGHATAMLAAARPVAAGLGIDPALVTCDVDNIGSRKVIEANGGRFEDQRGVKLRFWVPMR
>NC_021191.1|WP_015622089.1|4730262_4730868_-|class-I-SAM-dependent-methyltransferase
MHDEQSWDARYAESDRIWSGEPNAALVHEIAGLTPGTALELGCGEGADAIWLARQGWTVTAADISGVAVERAARFAAAAGVSVDFQRHDLAVSFPAGAFDLVTASFLYSQGDFPREAVLRRAAAAVAPGGVLLIESHQDHGAYAATHGPMRFPSPAELIADLELEPGQWEVLHAGTHDRMQLGPDGTPGPRVDGTVKLRRR
>NC_021191.1|WP_015622087.1|4728675_4730253_-|SpoIIE-family-protein-phosphatase
MTDLFDGAGTLREAYRRVDWAATPVGRPETWSRVLRGAFDLTLQTRAPITLLWGPQYVLLYNEAYVEMIGVKHPAALGRPCREVFPEIWDTIGPMLDSVVAGHGATWMEDLRLLMDRQGFLEETYFTFSYSPVRDEDGTVVGAIDIASETTAQVLGNRRLELLSRLNDRIADVEDVADLVEHALPVLRSAPEDLPGVDLLLPGTAALPVVPDREIELRRTDEGLRAWVRLTGVQPSQTDAVLSTRLSPHLAPDAAYLGFLRLLGTALAQGLNRARAREAERQATATQRALAEALQRSLLEPPEQPGHLQVAVRYQPAAEGARIGGDWYDSFVLPDGHLTVVVGDVTGHDRFAAAAMSQVRNLLRGISYAVQRPPSDVLTVLDDSMTSYRLNRFATAVLARVENPAPDRHLMRWSNAGHPPPVLVHPDGVVQLLETRGERLLGTRTTAGRTDHTVWLEPGSTVVFYTDGLIERRGRHLDDGLADLLAALRGHAHLDPEALCEHLLATVPGDTEDDVVLTVLRVGQP
>NC_021191.1|WP_015622098.1|4738891_4739509_-|CDP-alcohol-phosphatidyltransferase-family-protein
MAEQAAPGTVSNRIWTIPNVISFIRLLGVPLFLYLLLGPHHDVAAVIVLAVGGTTDWVDGYVARRMNSVSRLGELLDPFADRLYILATLLGFTVREIVPWWLTTALLLREAVLGVALLVLRRHGYGPPPVHYVGKTGTFVLLAAFPVLLLAKAVPSADTVLLPCGWALAWWALGLYWAAAALYLTQTRALLRADRDVTTREAVAG
>NC_021191.1|WP_015622100.1|4739774_4741727_-|VWA-domain-containing-protein
MAGNRFRYGAWRDGPDPLAPPYDVRAAVDEVGERVLGGESLRDALRELIRRGPREGRGLDELRARARRMRRDALRRGNLDGAVTRAQQLLDQAVAAERDELRGRDDMDARFNEAVLDNLPRSTSRAVEELNDYQWASTEARDHYQQILDGLRREVVEQRFAGMRDALQGSDPATDARVSEMVGDLNDLLGKHARGEDTDDAFQQFMAKHGDFFPEKPADVEELIDSLARRAAAAEQLMRSLSPQQREELSRLMDQALGDGPLRGQLAELTDNLRALRPTLNWGRGERMRGNQDLGYGDATAALGELGELDELLDQLGQEHPGATLDDIDVEAVERQLGRSAADDVRRLRELERELRRQGWVTRDEEGLTLSAKALRRLGRTALAQVFSDLSSKQRGEHDLRDAGAAGDLIGSSRRWEFGDEQPLDVVRTIGNAIRRSGPGSVPVRLQPEDFEVAETERRASAVVALCVDLSYSMFADGRWGPMKQTALALSHLVATQFPQDSLQIIGFGRYAMPLTQGELAAIDPDMVQGTNLQHALKLAGRHLRRHPGAEPVVLVVTDGEPTAHLEPDGEAYFNWPTLPETVQLTVQEVDHLTRYGATLNLFMLGEDPGLRRFVDAVARRSGGRVFSPEAEELGRYVVDDYVRSRRGKR
>NC_021191.1|WP_015622101.1|4741733_4743155_-|magnesium-chelatase-chlI-subunit
MTEASTLVPTPPSDLPRTLGELRASGHEFRTVKEELRDNLLDRLRSGAPRFPGIVGYEDTVLPEVERALLAGHDMVLLGERGQGKTRLIRGLIDLLDEWTPYITGSELREHPYQPLTPATRRLAAETGDLLPVSWLHRSERYGEKLATPDTSVGDLIGDVDPIKVAEGRALGDPDTIHFGLVPRTNRGIFAVNELPDLAERIQVSLLNVLEERDIQVRGYQLRLPLDLLLVASANPEDYTNRGRIITPLKDRFGAEIRTHYPLEVELEQDLIRQEAALSAAVPDHLIEVIARYTRAVRESPAVDQRSGISARFAIAAAETVAASALRRSGLRNEREAVARVCDLASVTSTLRGKVEFDSGEEGREVEVLAHLLRLATAETFRARLAGLDLSGFTDLVAEGAIIETGDLVSAEELLGQIGTVPGLAKVLGKLGLGDAPSPGQAASAVEFVLEGLHLTRRLAKELTDDGRTLYGS
>NC_021191.1|WP_015622102.1|4743222_4744056_+|PhzF-family-phenazine-biosynthesis-isomerase
MTEVEILRYAAFSTDPRGGNPAGVVLDATGLSEADMLDIAEDVGFSETAFLSGERVRYFSPLAEVPFCGHATVATAVALAERRGPGTFRFVTNAGEVPVTVDEAGRATLTSVPATVGELAEEDLTALLAALHWDRAELDPALPPRVAYAGAYHPVIAVTSRRRLAMLDYDVPALKSLMTARGWTTVQLVWRSGPAGFDVRNPFPVGGVYEDPATGAAAAAFGGYLRELGLVPGDAVITLSQGTDMGRPGELLVTLTPGTPTVRVTGAAVPIPEGAGR
>NC_021191.1|WP_015622103.1|4744068_4745703_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSATLIAKSLAAGHGDRMLFTALDLVVAPGDVVGLVGVNGAGKTTLLRTLAGLVPPESGSVTLSPPTATVGYLPQERERRPGETVRAFLARRTGVAPAQTAMDAAAEELATGAAGAEERYAAALERWLDLGGADLDERAGQVVAELGLAVALDHPMTALSGGQAARAQMASLLLSRYDIFLLDEPTNDLDLAGLHRLEEFVGGLRAGTVLVSHDREFLTRTVTAVLELDLAQQQVNLYGGGYGSYLEERATGRRHAREDYEEYAGRKAALEDRARMQRNWMETGVRNARRKAKDNDKIGRAVRAESTEKQAAKARQTQRMIERLEVVDEPRKEWELRMEIAAAPRAGAVVATLRDVVVRRGAFTLGPVTLQVDWADRIAITGANGSGKSTLLAVLLGRIAPAAGTAALGPGVVVGEVDQARGLFLGDEPLLTAFGTAVPELADADVRTLLAKYGLRAAHVLRPAATLSPGERTRAALALLQARGVNLLVLDEPTNHLDLPAIEQLESALATYPGTLLLVTHDRRMLDAVHTTRRLEVADGTVTG
>NC_021191.1|WP_015622104.1|4745712_4747347_-|family-10-glycosylhydrolase
MRRPPVRLVLVLAAVLLGVAVLGLGLLRAATYEEPAATPLAAGEQQLVPAAGTVGRCGDVPVRATRELRGMWLTTVLNIDFPSRPGLSEAQVKAEYLRWLDLAVARKHNAIFVHVRPSGDAFWPSAYAPWSEWLTGKRDGRSPGWDPMAFMVDEAHQRNLEFHAWFNPYRGTQPAPGGPGADVAKLAPDHPLRKHRDWAISYPDGRTARLYFDPGNPAARRFVEDAMLEAVQKYDVDGVHFDDFFYPYPEGGGSVFHDEKSYAKRTDKGQSLAAWRRQNVDTLVHEMSVRIKQLKPWVKFGISPFGIWRNKSTDPAGSDTNGLQSYDAQYADTRKWVRSGWLDYVVPQIYWEIGFGKADYAKVLPWWAQTVKGTQVQLYVGQADYRVGEKGAWKQPDQLDRQMALNDKYGVLGSVHYNSQAVRADKLGSVTRYTRDHYAGPALLPVMTRLPATPPGAPRISAARRTGTGVAVEWSPGAGPEPVSWALYRVNGTTADLVATGRRGAQDVADPAPPAGAATYCLSGLDRSGNEGPLSSPVPAPPAA
>NC_021191.1|WP_041832382.1|4747369_4748269_+|NAD(P)-binding-protein
MDVLVVGAGVAGLACARELSAGGAGVRVVERGRVVGGRLASRRFDGRYADLGAAYFVADDPAFQELAGQWQQRGLARPWTDTFRVVPGEPASGPMRWAAPGGLRSLAEDLAQGLDISLRTELTSLPPGTTTVLAMPGPQAVRLGLPAALDRAARAQTWEPVIAVVLTYGERGWPDFHGAFVNDHPVLATVCDDGDRRGDGAPVLVAHTTPAFARQHLDDPQRAAPAVAEAVGTLFGLTEAPRTHAHRWTFAQPRPQDGQFVQEGGIFLAGDVFGKPRVQTAWQSGRAVARAILGQSTER
>NC_021191.1|WP_015622106.1|4748250_4749465_-|glycogen-synthase
MTDSRTKSDLRVDLITREYPPEVYGGAGVHLEYLARDLRDLAEVRVHCFGAPRDEPGVTAYPVPATLGEANAALQTMGVDLAIAAGAAGTNIVHSHTWYANFAGHTAKLLHGVPHVVTTHSLEPLRPWKAEQLGGGYALSSFCERTAIEAADAIIAVSGGMKKDVLTAYPSVDPDRIHVVYNGIDTAQYAPDRDTGVVERLGIDLNRPSVVFVGRITRQKGLPYLMRACHDLPPETQIVLLAGAPDTPEIAAEVEGLAMQLRSARDDKGVIWVQEMLPKHEVVQVLTHATVFVCPSIYEPMGIVNLEAMACETAVVATATGGIPEVVADGETGILVPIEQLADGTGTPVDPDRFVADLGAAIRTLVLDPDRAARMGLAGRQRAVEKFSWASIAQDTMAVYRSVL
>NC_021191.1|WP_041832383.1|4749525_4750758_+|glucose-1-phosphate-adenylyltransferase
MAVKVLAIVLAGGEGKRLMPLTADRAKPGVPFGGIYRMIDFVLSNLANGGYLKIVVLTQYKSHSLDRHITKTWRMSTLLGNYVTPVPAQQRLGPRWFAGSADAIYQSLNLINDEKPDYVIVFGADHIYRMDPKQMVNDHIASGASVTVAGIRQPKSLSDQFGVIDVAEDGKRIRAFREKPVDVEGLPDSPDEIYASMGNYVFTTRALCEAVSLDAQNPDSKHDMGGNIIPMLVEKGEANVYDFRDNEVPGSTDRDRGYWRDVGTLDSFYEAHMDLIATVPIFNLYNMDWPIYTNYGSWPPAKFVHGYDDRQGRAVESMISPGVVVSGSLVERSVISPNVRVNSWSHVENSVLMEGVQIGRRAVIRNAIIDKNVVIPEGAQIGIDLDRDRKRYTVSDGGIVVIGKGQKVEP
>NC_021191.1|WP_015622108.1|4750918_4751404_+|SRPBCC-family-protein
MLIEVVTDIDAPRTVVFDLELDMDVHAASLATSAEQATTSTGRPRLGPGDEVTFRARHLGLTWHMTTRISAHDRPRRFVDEQTRGPFRTLHHEHLFTALSPARTRMTDRMTVTAPLGPLGHLVTRLLLAPYLRRLLHQRGAHIKHLAEHPGSRPDQPVHPA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_13

5196549-5196639

Orphan

Consensus_repeat	Method
GAACCATCGCTACGCCTCGCTCCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_13

>merge|NC_021191|13|5196549-5196639|CRISPRCasFinder
GAACCATCGCTACGCCTCGCTCCCCGACCTGACCGCCCCCACCCCCCAAGGCGCCCGACCGTGAGGAACCACCGCTACGCCTCGCTCCCCG

>NC_021191|13|12|5196549-5196639|CRISPRCasFinder
GAACCATCGCTACGCCTCGCTCCCCG	ACCTGACCGCCCCCACCCCCCAAGGCGCCCGACCGTGAG
GAACCACCGCTACGCCTCGCTCCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015622544.1\|5197522_5198053_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015622557.1\|5209512_5210514_-\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|237724
NC_021191.1\|WP_157408460.1\|5191708_5194501_-\|CHAT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378942
NC_021191.1\|WP_015622552.1\|5203403_5204165_+\|GAF-and-ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377145
NC_021191.1\|WP_015622550.1\|5202584_5203052_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015622535.1\|5187322_5188135_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_041832448.1\|5189162_5189654_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NC_021191.1\|WP_157408848.1\|5198105_5198672_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NC_021191.1\|WP_051167532.1\|5194561_5195914_+\|S8/S53-family-peptidase	unknown	unknown	gnl\|CDD\|173787
NC_021191.1\|WP_041832449.1\|5191271_5191694_-\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NC_021191.1\|WP_015622534.1\|5186941_5187289_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NC_021191.1\|WP_015622532.1\|5186651_5186816_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015622548.1\|5199610_5200150_-\|peptide-deformylase	unknown	unknown	gnl\|CDD\|234668
NC_021191.1\|WP_084504227.1\|5205404_5208878_-\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NC_021191.1\|WP_157408849.1\|5208882_5209482_-\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
NC_021191.1\|WP_015622539.1\|5190511_5191090_-\|redoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|239268
NC_021191.1\|WP_015622549.1\|5200314_5202546_+\|bifunctional-diguanylate-cyclase/phosphodiesterase	unknown	unknown	gnl\|CDD\|238923
NC_021191.1\|WP_015622537.1\|5188353_5189160_+\|methyltransferase	unknown	unknown	gnl\|CDD\|252734
NC_021191.1\|WP_084504225.1\|5187923_5188346_+\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_021191.1\|WP_084504226.1\|5203094_5203346_-\|DUF3040-domain-containing-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015622557.1\|5209512_5210514_-\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
NC_021191.1\|WP_157408460.1\|5191708_5194501_-\|CHAT-domain-containing-protein	gnl\|CDD\|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	2.65254e-23
NC_021191.1\|WP_015622552.1\|5203403_5204165_+\|GAF-and-ANTAR-domain-containing-protein	gnl\|CDD\|377145	pfam03861, ANTAR, ANTAR domain. ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	1.62778e-13
NC_021191.1\|WP_041832448.1\|5189162_5189654_+\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	2.91674e-45
NC_021191.1\|WP_051167532.1\|5194561_5195914_+\|S8/S53-family-peptidase	gnl\|CDD\|173787	cd00306, Peptidases_S8_S53, Peptidase domain in the S8 and S53 families. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) family include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	5.8674e-38
NC_021191.1\|WP_041832449.1\|5191271_5191694_-\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	1.08181e-36
NC_021191.1\|WP_015622534.1\|5186941_5187289_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.08682e-15
NC_021191.1\|WP_157408848.1\|5198105_5198672_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	8.45892e-21
NC_021191.1\|WP_015622548.1\|5199610_5200150_-\|peptide-deformylase	gnl\|CDD\|234668	PRK00150, def, peptide deformylase; Reviewed.	7.19047e-69
NC_021191.1\|WP_084504227.1\|5205404_5208878_-\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	1.76906e-158
NC_021191.1\|WP_015622539.1\|5190511_5191090_-\|redoxin-domain-containing-protein	gnl\|CDD\|239268	cd02970, PRX_like2, Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these proteins do not contain the other two residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. TRXs alter the redox state of target proteins by catalyzing the reduction of their disulfide bonds via the CXXC motif using reducing equivalents derived from either NADPH or ferredoxins.	4.55965e-13
NC_021191.1\|WP_015622549.1\|5200314_5202546_+\|bifunctional-diguanylate-cyclase/phosphodiesterase	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	3.23554e-101
NC_021191.1\|WP_015622537.1\|5188353_5189160_+\|methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	3.27189e-120
NC_021191.1\|WP_084504225.1\|5187923_5188346_+\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.17257e-42
NC_021191.1\|WP_157408849.1\|5208882_5209482_-\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	2.68011e-78

>NC_021191.1|WP_051167532.1|5194561_5195914_+|S8/S53-family-peptidase
MTIASRWPLPDRRSATQLANDQEDVRRQVVKLTDANTDESARQQQNQLVQRILQRQRTAATAQATPFLHLPLDNAGDRVSLVASGELVVDADPATLDALGPLLSGYQPADRHGRSPHRRTRVFRAHAKTAEQLRADASRLRSHNGVEANVNTIVPLGYVTKGDSYPGSTVAPAAFATNGATAPVRVAIIDTGITAEQRTDGWDSGVIRAGTDPVNVLAPLDRIDWFAGHGTFATGIVRQIAPDCDVAVYRFTTTDGLGTDEAAADMMIQAAEDANGERLIINASFGTPAIDGVPPLAIQEAINHITEQHPSVLIIASAGNDGRDQPLYPAAFPDVVAVGALNSDLTPASFTNHGTWVDCAAVGVGVISTFVEGKLPPEPGIGTDITFGANSWATWSGTSFSAPQITGAVAALCGEDPALTPRQALDQLFAGRPTAPGLGKVIHILPGTPL
>NC_021191.1|WP_157408460.1|5191708_5194501_-|CHAT-domain-containing-protein
MAASLIPADLRDRADAAYKRVVLDPVRYAAEAQELVAHATATGDTEALVAGLRAVAYVRHVKLDNVGAGRLLDRAVRLAEGAGLARRLAGVLVTRSLALQELGRYDAAARDLRRAGSLADAAERPEIRFQLAVLDHNRGRLDDAATAYTGVLDDPAAPPVVWVKAANNLANVHTLRGRPDEALGYLTRAAALARDLGARYTAIVANSHAWSSYHAGRLAESVRRFEEAGRLHAEAGLPLGEHHVEYADVLRDLRLLDEAMAAARSAWAEFDRHGAKLMAAEARLRCARLALELGDPATAVADAQAAVRDFRRQRRPAWAARAAVTEAEACAALEGDSTAVLQRLRRAAATLQRLGLREEAAYARLAAGRVALALHRPAAARRELVAVGELASGQSLLVRLRGHLAQALLAEAQDPDQVLRACMRGLRDLSRHRAALPSLELRVLASGHGAELGEVGLRTLLRDRPLATAAPDDNDAPAVRTTSVPGPGEDASAGSAAGQRTAPDESRLASGVRATSAPAAGRASAARIFEWLERTRAAALLRVHPPATGVDEDVVALRNVEQELRDARLARGEEPAALLARQSALETRIRRRSWSGDEGTGGEAAAPAALPELRRELAGRWLAEYAVIGDRALAVVVEPRRTRVVELGAVTALRAELAAAEFGLRRLLTGTRFAAAARTATQQAIDALARLLVEPLRVPPGVPLVVVPSTQLLGVPWSALHPAPVSVAPSGGLWAHARRARPAPGDPAVAVVAGPDLDGAGAEVKAVAAEYDGARVLVPPESTADATIALVKRAGLAHFACHGRFRSDSPLFSALQLTDGPLTLYELLAHGVAPRRMVLASCHSGAQQPYGGNEVLGFASAMMSHGSVGVAAADVPIPDGASAGAMTVLHQRLARGETLPTAVWHARAALAEGGAEEYVAWYGLTAYGPG
>NC_021191.1|WP_041832449.1|5191271_5191694_-|thioredoxin
MEIVTCQQCGQRNRIRAASAGRPVCATCKAALPWIVDAGDDTFAEVAEHSSTPVLVDLWAPWCEPCRMVGPALEQVARELAGGVKLVKVNVDTAPRLSRRFAVQAVPTLLLLKDGEVVARQAGAAPAPVLRRWVDQQLAA
>NC_021191.1|WP_015622539.1|5190511_5191090_-|redoxin-domain-containing-protein
MTVTSARQSRATDAASRHQDAAFRHQMERDAVWSRMISPGARIPDLPLIEADLGPIFLHRLLDTGPLVLMFFAHAGAAGAEAALRTYEKGLAGVDAHLVAVSPQRPERLAELKHRARLTMLVAADPRHALIDAFNIGYSSPAESGALGTGRSTLPYPAVVVADRSGVVRFVEVSPDPANHTRPAAIIDALRC
>NC_021191.1|WP_041832448.1|5189162_5189654_+|N-acetyltransferase
MTIAILPMTAAHAQAVLDIYAAGIATGNATFETAVPQWAVFDRGKLPAHRFVAVEAGTVVGWVACSPVSARAAYAGVVEHSVYVDPAAGGRGVGRRLIEELVTSTEAAGIWTIQSGVFPENTASLALHDRCGFRRIGVRERIGRRDGVWRDVILLERRSPAIG
>NC_021191.1|WP_015622537.1|5188353_5189160_+|methyltransferase
MMVAMTAIDSTVPHPARRYNYWLGGKDNFAADRKSGDELEAAFPNVRKGALANRALLRRATRFLAAEAGIRQFLDIGTGLPTADNTHEVAQSIAPESRIVYVDNDPLVMVHARALLTTSPEGRTAYIEKDLRDPAEILADPTLRETLDLGRPVALMLIAVLHFVHGHGAAKPIVQRLMAELPSGSYLVVTHATSDFGTPEQAALYQRMVEQGRSDVWTRSRAEVADLFEGLELLEPGVVPASKWHPAPGDPEFADNEVNVWTGVARKN
>NC_021191.1|WP_084504225.1|5187923_5188346_+|GGDEF-domain-containing-protein
MVTHGHSGESFAVIFIDLDGFEQVNDRLGHSGGDALLREVAGRLSGCLRAADTIARFGGDEFTVLTERLGDPAAARVAAARVVEAIGRPYLLEAGAAHVTASVGIAVNRPGTGADAVLRAGDLAMYTAQKAGKARYVVSG
>NC_021191.1|WP_015622535.1|5187322_5188135_+|hypothetical-protein
MSWAPPPRTRRQLVAALLVLLVPAAGGVVTVVVGYALTRSEQRYAAQAMDRYTADVSAAVTTEVARYGDTLTDMARAVAAESALTRTDFEEITEGIDADRLPGVSGIAFVAEVPTARTAATQRLWRARGATGLTLTPEGVKAHDPGLVEPDPALVRERAISVGQRVWRLTVHPTASLANRADERIRTIALDACLAVTVALAGDARPLGRVVRGDLHRPGRLRTGQRPARAQRRGRPAARGGRAAQRVPARRRHDRPVRRRRVHRSDRAAG
>NC_021191.1|WP_015622534.1|5186941_5187289_+|STAS-domain-containing-protein
MRLQYDIIRVMIDRGQEVCVRLFGDFDESARHDLREALSVAANDNIAPRFVVDLQETRFLGSEAIGALLSGCLRAQEAGKWVQIVNAHGVVRTVLQVTGVLELFDAPPGTCREIA
>NC_021191.1|WP_015622532.1|5186651_5186816_-|hypothetical-protein
MVLDTLPVPQFRADNTAEDAPPVAPAADHSDEAMARLRHPFDPQPAGAVTRENA
>NC_021191.1|WP_015622544.1|5197522_5198053_-|hypothetical-protein
MTDPTEPGDLSPDDGPLLARLEAMFREADPAPSDLVTLAKESFILRALDAELAQLVEDSDTSAAEPAASRAMAVRGAGTVPHPRQLTFQVVDEQGRDEVVIAVQVEAAGSRRRLTGHLAPQGPATIEVRQPAADQPRRTEADARGLFIIDDVLPGPMSLTLHRPGAAPVATQWTLV
>NC_021191.1|WP_157408848.1|5198105_5198672_-|sigma-70-family-RNA-polymerase-sigma-factor
MALLVGKALGGDHAAWNRIVERYSARVWAICRIHNLGQADAADVFQQTWLRALENLGALRDPDRFGAWLGTTCRNEARATLRRGRRTQPVEDSWLIDREAGPEGDPVRPLLTAARDAELWQAFSQLGSRCQQVLRVLVVDAEDRRPSYELAASALDMPIGSLGPTRKRCLNQLRRFLTEGIDGETRES
>NC_021191.1|WP_015622548.1|5199610_5200150_-|peptide-deformylase
MTVLPITLIGDPVLRTPAAPVTDFDAELHKLVADLTETLADRRGAGLAAPQLGVGLRVFALAPQLSDGKFDHLVNPVLEFPDEEVQDGPEGCLSIPGIYLDTVRRQNVVAKGYTRHGDPIQLVGAGMLARCVQHETDHLDGVLFIDRQSPERRERLLTTIREAAWSDGMPAPEVRLSPH
>NC_021191.1|WP_015622549.1|5200314_5202546_+|bifunctional-diguanylate-cyclase/phosphodiesterase
MVARLPRAALGLITLILLGQVLALTLDSARNPVLGLSLLLLDGLGLIYSARAARSPHTRLTWLLAALGRGFSLISTVSFTVNEVTGSMVWWWTAVLSGLMMFLCLTGAALSVSARRLENRQQAAFLAELVTVLSSGFMLVWYFVLDRVLQREATLHWIFEIGYPLGTLLLLVAVSAVLLRGAMAHVNRAVTMLLGGILIYAVADTLFSAVRAEGDQAGHSSLASAALVLASLVMTVGAMQQCAIAPQAGEPDTAEMPGWSTRLPYVAVGFGNVLLLVLTIRGHAFLLWGGLTAGQTMMTTALAVRQYLSLRDSRRINVTDTLTGLANVAGMRQALDRAEQRPEPAALMLLDLDGFKQVNDRLGHEAGDRVLIEFARLLRQSVRRGDLAGRVGGDEFVVLLADVHRTEQVVAVAERILATLAASPLTLAGEAVTIRCSIGMALSQPGDTAKELQHRADVAMYESKRAGTHGWRLFDLSMTDRRNRDTGLADALEAALGTGQFQLAYQPLVDLAGGKPVGVEALLRWEHPVHGAISPAEFIPIAERTGSIVAIGRWVLQETCRQVQQWRSTQPAAATLYASVNVSARQLQEPAFLGDVLAALAVSGLPADALVLEITESAIVDEQIAVPACEALRRHGIRVAVDDFGTGYSSLHLLTQLPVDILKIDRSFVARLDGTRRGAGVAEAVIRLADVLGLTTVAEGIETTAQVAELQLLGCPVAQGYLFARPMTAADFAASLSAREPAA
>NC_021191.1|WP_015622550.1|5202584_5203052_+|hypothetical-protein
MATGFLAGAAAGAAGTAALNAATYLDMTVRGRAASSTPEQTVEALEDRLPVSVPGEGDTRTNRVSGLGSLTGVITGVGIGATWGMLRRAGFRPPLPVGAVLAGITAMASTDVSMARLRVTDPRSWSATDWVSDLLPHLIYGAVTYATVSALDRNR
>NC_021191.1|WP_084504226.1|5203094_5203346_-|DUF3040-domain-containing-protein
MVAAEGKGEDSFEDIVANLHREDPGFTAAFQEERRPPGRAPMVIGAVLCLIALAMLAFGGVKGAVLSVLPWLAGMVCVLKGRG
>NC_021191.1|WP_015622552.1|5203403_5204165_+|GAF-and-ANTAR-domain-containing-protein
MTQPYAALLDALLDDPDAVTFLRRVVRIAADDVLPGAACAGLMRTGAREWVTAASDQLAARADEIGYGADEGPCLDAIAGGSVVAVGNLGQDGRWPAFRPYAMVVGVSSLLAVPLRAEPRMAAALMVCSGQPDSFTGARRDSFEAFAARCAGGLAQLQRITDLVDIEVQLRQALDSRGIIDQAIGIVMAQQRCAADTALGLLRAASQRTNRKLRELSTDIVTRVGGQSPCPPTPFQIRSHVTSSPRPGRTPFR
>NC_021191.1|WP_084504227.1|5205404_5208878_-|phosphoenolpyruvate--protein-phosphotransferase
MVGLVVVSHSRPLARAAVALAREMTTGTPVRIEIAAGLDETTTGTDAIAIADAVAAADDGDGVLVLMDLGSAVLSADLALEMLDDDLRTRVDLSPAPLVEGLLAAAVTAATGAARPDVAAEATAGLAGKQSHLRSTPPAGTPGAPPAAAPVIEFPIINEHGLHARPAARLVTDLRTFDATVELRNATTGTPWVPATSLTRVATLGAVRGHTLQIRATGPQATAAITHATTLAATAFGEPAEASADAIPQTRAGQAAARTPSPTSAGPVAASAGSGASAGSAAAPAGSGASAGPVASAGPAGFPSSGEAAAWAGPAPSGGGVASTGPASSSEVDAPDERALSDEAALPDEGASSVGAVASGGRTSSGASGASGASGASGAEGPADLAIPPEGPRSVASGGAAAFDASAGRAVSGATVAESPAHPAFPPEVSPAAASLTEISATGSVSGEWAAGSSAGRSADRTSSSRGSSAAGVGEAARAGEAAGAVGDVVATGDVRPGEAAGVGGAGETAYVGEAVGAGAAAGAVGARNPAGAVGPGEAVAAVRLGEAAGVGEAVVTAGAGEAAGAGGAGEAADAAGGRRAAGAAGVVGGGQVAGVGGVAEAAGAAGAEEVVGVAGAAERVGSLGEVAAAVPGKSVGGTPAAPGVGVGPKRELRRAAVVVPVEESRGAAVETARMQDALAAARREIGRQRGEIFRAHLALLDDDAILAEVWGRIAGGATAPEAWVAATGRVAGEFAALADPYLRERGADVRAVADQVARVLLGLPRGAVSGDGVVFAEELTPAEAAGLDAGRVAGVVQRAGSPTSHATIVLRGRGIPAVVGWPGPDVAEGTPVALDGSTGEVVVDPPPGVLRRFEERAAAARAEQRASVARAGAAAVTRGGVPVAVGANVGSVGDARVAAANGADLAGLVRTEFLFLGRDSAPDVDEQVSVYLSIAEALGGRRITLRTLDVGGDKPLPYVPMAAEANPFLGVRGIRHSLAHRELFAAQLRAIVEVARRTPVSVMFPMVTSVDELVAARRVLDEAGGVVPGLRVGIMIEVPAAALTAARFTPYVDFVSVGTNDLTQYTLAAERGNPALAGLAGARDPAVLRLIGAVCREIGTGVTVAVCGELAADGTAVPELLGLGVRELSVAPPRVPAVKDAVRRCPDPLPAPTAPV
>NC_021191.1|WP_157408849.1|5208882_5209482_-|dihydroxyacetone-kinase-subunit-L
MREFARLISAGTVLLTDLDSAIGDGDHGFNMDRGMTAVTAALDAQPPDTPSALFKLVGMTLISKVGGASGPLYGTAFLRMAAAAGATVEPAGLATILRAGLDGVIARGKAEPGDKTMVDTLTPAVEALESALAAARPLPEALRAAVTAAEQGRDATIPMVARKGRASYLGERSAGHADPGATSAAMLLTAAATALSGQD
>NC_021191.1|WP_015622557.1|5209512_5210514_-|dihydroxyacetone-kinase-subunit-DhaK
MNKLINDPVSVVTDALHGIAAAHPDLRVDHENRFVCRGDAPVRGKVGLVSGGGSGHEPLHGGFVGPGMLDAACAGEIFTSPVPGQMVEATKAVDGGAGVLHIVKNYTGDVLNFEMAAEIAEAETGVTVTPVIVDDDVAVQDSLYTAGRRGVGTTVLLEKIAGAAAEQGRDLAAVADIARKVNANGRSMGVALTSCTVPAAGKPTFDLPDGQMEVGIGIHGEPGRRRVPVAPAAEIADLLVSPILADLDLTGGAGVIAFVNGMGATPLIELYVMFAEVSRILQRAGVGVARSLVGPYITSLDMAGCSVTLLKADDEILRLWDAPVRTPGLRWGM

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_14

6728924-6729034

Orphan

Consensus_repeat	Method
GTCGTGCCGGGAGCAGGCGGCGCCTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_14

>merge|NC_021191|14|6728924-6729034|CRISPRCasFinder
GTCGTGCCGGGAGCAGGCGGCGCCTTCCTGGCCGGTGTCGCGGTCGTGCCGGGAGCAGGCGGCGCCTTCCTGGCGGGCGTCGCAGTCGTGCCGGGAGCCGGCGGCGCCTTC

>NC_021191|14|13|6728924-6729034|CRISPRCasFinder
GTCGTGCCGGGAGCAGGCGGCGCCTTC	CTGGCCGGTGTCGCGGTCGTGCCGGGAGCAGGCGGCGCCTTCCTGGCGGGCGTCGCA
GTCGTGCCGGGAGCCGGCGGCGCCTTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_041832645.1\|6741468_6742401_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_021191.1\|WP_015623889.1\|6729587_6729923_+\|SCP2-sterol-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|376720
NC_021191.1\|WP_015623895.1\|6740137_6740878_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274736
NC_021191.1\|WP_015623898.1\|6742397_6743042_-\|adenylate-kinase	unknown	unknown	gnl\|CDD\|273569
NC_021191.1\|WP_051167837.1\|6738827_6740066_-\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NC_021191.1\|WP_015623877.1\|6716403_6718563_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015623883.1\|6723065_6724244_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227162
NC_021191.1\|WP_015623886.1\|6727256_6728117_-\|TlyA-family-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|224110
NC_021191.1\|WP_157408546.1\|6743633_6744146_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NC_021191.1\|WP_015623882.1\|6722107_6723037_-\|copper-transporter	unknown	unknown	gnl\|CDD\|378653
NC_021191.1\|WP_015623881.1\|6721248_6722064_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223548
NC_021191.1\|WP_041832642.1\|6724490_6726236_-\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NC_021191.1\|WP_015623879.1\|6718559_6719687_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_021191.1\|WP_157408545.1\|6728116_6728299_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015623899.1\|6743046_6743595_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015623890.1\|6729935_6730925_-\|HAD-IIA-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NC_021191.1\|WP_041832644.1\|6740859_6741456_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_021191.1\|WP_157408912.1\|6744162_6744966_+\|endo-alpha-1,4-polygalactosaminidase	unknown	unknown	gnl\|CDD\|377061
NC_021191.1\|WP_015623885.1\|6726289_6727177_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|235121
NC_021191.1\|WP_015623880.1\|6719683_6721252_-\|virulence-factor-MVIN-family-protein	unknown	unknown	gnl\|CDD\|240528

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_041832645.1\|6741468_6742401_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	6.42152e-26
NC_021191.1\|WP_015623889.1\|6729587_6729923_+\|SCP2-sterol-binding-domain-containing-protein	gnl\|CDD\|376720	pfam02036, SCP2, SCP-2 sterol transfer family. This domain is involved in binding sterols. It is found in the SCP2 protein, as well as the C-terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.	4.28622e-09
NC_021191.1\|WP_015623895.1\|6740137_6740878_+\|hypothetical-protein	gnl\|CDD\|274736	TIGR03708, poly_P_AMP_trns, polyphosphate:AMP phosphotransferase. Members of this protein family contain a domain duplication. The characterized member from Acinetobacter johnsonii is polyphosphate:AMP phosphotransferase (PAP), which can transfer the terminal phosphate from poly(P) to AMP, yielding ADP. In the opposite direction, this enzyme can synthesize poly(P). Each domain of this protein family is homologous to polyphosphate kinase, an enzyme that can run in the forward direction to extend a polyphosphate chain with a new terminal phosphate from ATP, or in reverse to make ATP (or GTP) from ADP (or GDP). [Central intermediary metabolism, Phosphorus compounds].	1.94552e-97
NC_021191.1\|WP_051167837.1\|6738827_6740066_-\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NC_021191.1\|WP_015623883.1\|6723065_6724244_-\|hypothetical-protein	gnl\|CDD\|227162	COG4825, COG4825, Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown].	6.53967e-123
NC_021191.1\|WP_015623886.1\|6727256_6728117_-\|TlyA-family-RNA-methyltransferase	gnl\|CDD\|224110	COG1189, COG1189, Predicted rRNA methylase [Translation, ribosomal structure and biogenesis].	5.87978e-105
NC_021191.1\|WP_157408546.1\|6743633_6744146_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	1.09624e-10
NC_021191.1\|WP_015623882.1\|6722107_6723037_-\|copper-transporter	gnl\|CDD\|378653	pfam11382, MctB, Copper transport outer membrane protein, MctB. Outer membrane channel protein MctB in Mycobacterium tuberculosis is part of a Cu resistance mechanism that ensures low intracellular Cu levels in the bacterium. Human resisitance to bacteria, mediated via IFN-gamma-mediated activation of macrophages, may involve the use of reactive Cu(1) in the presence of hyrodgen peroxide, since acitivated Cu is toxic to bacteria. IFN-gamma stimulates the trafficking of the Cu transporter ATP7a to the vesicles that fuse with phagosomes and these phagosomes are found to have a high Cu content and an increaseed bactericidal activity against E.coli. Using MctB, Mycobacterium tuberculosis may limit the amount of excess Cu within it whole in the host.	3.90417e-81
NC_021191.1\|WP_015623881.1\|6721248_6722064_-\|hypothetical-protein	gnl\|CDD\|223548	COG0472, Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane].	0.00112984
NC_021191.1\|WP_041832642.1\|6724490_6726236_-\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	4.24508e-179
NC_021191.1\|WP_015623879.1\|6718559_6719687_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.89805e-46
NC_021191.1\|WP_041832644.1\|6740859_6741456_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	6.90602e-34
NC_021191.1\|WP_015623890.1\|6729935_6730925_-\|HAD-IIA-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	5.97191e-84
NC_021191.1\|WP_015623898.1\|6742397_6743042_-\|adenylate-kinase	gnl\|CDD\|273569	TIGR01351, Adenylate_kinase, adenylate kinase. Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP\|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions].	2.03416e-74
NC_021191.1\|WP_157408912.1\|6744162_6744966_+\|endo-alpha-1,4-polygalactosaminidase	gnl\|CDD\|377061	pfam03537, Glyco_hydro_114, Glycoside-hydrolase family GH114. This family is recognized as a glycosyl-hydrolase family, number 114. It is endo-alpha-1,4-polygalactosaminidase, a rare enzyme. It is proposed to be TIM-barrel, the most common structure amongst the catalytic domains of glycosyl-hydrolases.	9.9814e-92
NC_021191.1\|WP_015623885.1\|6726289_6727177_-\|NAD-kinase	gnl\|CDD\|235121	PRK03372, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	2.113e-151
NC_021191.1\|WP_015623880.1\|6719683_6721252_-\|virulence-factor-MVIN-family-protein	gnl\|CDD\|240528	cd13123, MATE_MurJ_like, MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	4.97734e-59

>NC_021191.1|WP_157408545.1|6728116_6728299_-|hypothetical-protein
MQRAEVTPGIIDGSESTGHPAVDAVLQALANAATLAPGDQLAEFEAAHQVLQETLASIDR
>NC_021191.1|WP_015623886.1|6727256_6728117_-|TlyA-family-RNA-methyltransferase
MARRARLDAELVRRKLARSREQAAALVAAGRVQVRGTVAHKVATMIDPADPVVVTGEDPADEYVSRGSHKLAGALAAFTGIAVAGKRCLDAGASTGGFTDVLLRAGAAQVYAVDVGYGQLAWPLRTDDRVVVMERTNVRTLTPDMIDGPVAVTVADLSFISLRLVLPALAACTAADGDLALMVKPQFEVGKERVGSGGVVRDWQLRAEAVLDVAATAAGLGLGVASVAASPLPGPSGNVEFFVWFRRDAPPADAERIRAVVAAGPSGEVNSAEPASMPVPAPLEDA
>NC_021191.1|WP_015623885.1|6726289_6727177_-|NAD-kinase
MSRSALLVTHTGRRQSTQHAQTVARDLVTNGFEVRVIAEEVDDLELPPGVTPVDDPTAAEGVEIVFALGGDGTFLRAAELARPVKAPLLGINLGKVGFLAEAELQNIDQTVRDIVAGDYTVDERLTLQVRAEYDGRLIADSWALNEVSVEKGQRAQMLELLVDVDGRPLSRYGCDGVVCATPTGSTAYAFSAGGPVVWPEVEALLLVPISAHALFSRPIVTAPTSTFVLTVDPYTSFATLCCDGRRTWDLPPGAQVTVQRGDLPVRLVRLQPRPFTDTLVAKFHLPVEGWRGNRR
>NC_021191.1|WP_041832642.1|6724490_6726236_-|DNA-repair-protein-RecN
MLEELRITGLGVIDDTTLRLTTGMNAITGETGAGKTMVVTGLGLLFGGRADAGRVRADPGRAMVEGRLRLDGRLGASVQARITDAGGEVDDDGSVLLSRTVTTEGRSRAHVGGRSMPVAMLGEVGEQVVAVHGQQDQLRITRPAEQRASLDRYAGADHEKLLETYRQSYTQWRTVVDDLADRRRNARQRSQEADLLKLGLDEISRVDPQPGEEEDLRAEVQRLEHAEGLRLAAAQAAQALAGGVEATDDTPDATVLLGTARRTLEAQAPVDAMLGELAARIEEAATLVGDVSAELSAYLDQLDADPARLEAIYERRAELRALTRKYADDVDGVIAWAEHARTRLAALDTSDELLDELDKERLRLAGQVAELAGRVTAARTEAAGRFSEQVSVELAGLAMPHARVEIVVLPRTAGRDEPMIDELAVGPDGADEIEIRLIAHPGAPALPLQKGASGGELSRVMLAIEVVFAGAGGPPTLVFDEVDAGVGGQAAVEIGRRLARLARTHQVLVVTHLPQVAAFADRHLVVAKDTGGAITTSGVKIVEETDRARELARMLAGLPDSDLGIAHAEELLAVAEKEKRG
>NC_021191.1|WP_015623883.1|6723065_6724244_-|hypothetical-protein
MRLPTLRRTRSVEAGALSGTARLDRRTKRLVGRLRPGDIAVIDHVDIDRVAADSLVAVGVAAVLNAKPSISGRYPNLGPEVLVQAGIVLVDSLGEDVFDALSEGDLISIDGDTILLDGEPVGTGIRQDAESVAKSMADAREGLSVQLEAFAANTMEYLKQERDLLLDGVGVPDIETRIAGRHVLIVVRGYDYKADLDVLRPYIREFKPVLIGVDGGADALVESGYTPDMIIGDMDSVTDDVLRCGAEVVVHAYSDGRAPGLARVQGLGVPATTFPAAATSEDLAMLLADDKGASLIVAVGTHANLVEFLDKGRGGMASTFLTRLKVGGKLVDAKGVSRLYKQNISGSSLLLLVLSAIAAMASAVAVSTIGKAYLSVVSEWWDNLVFQLGQLF
>NC_021191.1|WP_015623882.1|6722107_6723037_-|copper-transporter
MINFRYHVVSLTAVFLALAIGLVVGTTALNGPVSDALKSRVDALSKDNSNYRDQANQYREELDSSADFATELAPALLNGKLTDRRVLVVVLPTGKDYADGVTSMLKVAGATITGRLTVEDKFFDPANSLELLELAERASRPTASTEGLPLNSDGVETSSALLSVALLQKSPAVSPEDLTAVLTAYTEPGYVTPSDDIAAGAEATVVVSGLPPVDRDAAKKNQNAVMLTTQFVKDHPVVVAGNGIGEGNLVSAVRGDPFLVKQVSTVDNASGKQGQLTTALTVIERLVQGKVGQYGLEAGASSKVPKVAG
>NC_021191.1|WP_015623881.1|6721248_6722064_-|hypothetical-protein
MAGRVTSSGLGALTARAVLAWVRHDQRAAQLERTNFHGRTVTLAGGPALAAGATLGAAFGAPGAAATAAVLVAGTASGAVGFYDDIVGNRPEQKTAKGFRGHLAALRAGRVTSGLVKIAGVGTAGLVASALLRRHRSGSVLLGAGVIAGSANLLNLLDLRPGRAIKAATVIGTPLVAGRGGALTAGTLGASAALLPDDLGEEIMLGDAGANALGALLGVALVARTGTAGRAVALGVLGALTAASERVSFTKVIQDTPWLRKADELGRRPNP
>NC_021191.1|WP_015623880.1|6719683_6721252_-|virulence-factor-MVIN-family-protein
MTATRTRAAGVAGAAAVITVLTVLSRLAGFGRTFVFLHTVGDRTLGNVYNAANTLPNIVFELVAGGALASLVVPLIAGAVADGDRERVGAVASALLTWVLTLMVPLAVLVALLAGPVAGMFDVPPDAQDVAARMLRVFAPQLPLYGIGIVLTGVLQAHHRFAWPVIAPLLSSVTVMAAYVSYAAADGARSDVAGLSRTGELLLSAGTTAGVVVLALCLVIPLRRLRLRWRPSYRFPGGEGRQAMRLGWAGAVTVGAQQVMVLVVLLLAVSGPLTAYTAAQTVFMVPWAVLAVPLATAVYPRLATAAARGDEVSYAGSLSGTARSVMLLACLGAAALAAVAWPAARVIATPSAAPGIVGFAPGLLGYALFALLSRALYARGATVAAAAATASGWGVAAVLAFVVAAVLPEQRQVAGFAAAGAVGMSVIGLLLVLAVRRHAGPAALAGLPRTTAVGIVAAVVAGFAGWLASGGLGGGTPGAWWSVLQGMLGGVVVAAVFLAVAYPLDRGDLKPLVTRILRRGRS
>NC_021191.1|WP_015623879.1|6718559_6719687_-|glycosyltransferase-family-4-protein
MSDGAQAAWHGSVALVLASSTGGVGQHVRSLVKGMLAAGCRVLVVGPAATDEHFGFTAAGAQFTAVEIPASPGPQDSGAIRAMRRALSGPELDVVHAHGLRAAFVAALARPAAPLVVTWHNAVLGKGLRAGASALVERIVARSATLTLGASEDLVARAESLGARHARLAPVAAPVPAAARRSRSAVRAEFRVAPDTPLVLSVGRLHPQKRYDLLVDAAARWRALEPAPVTVVAGSGPSYMSLAQRISRLHATMHLLGHRTDVPDLLAGADLAVVTSEWEARQLFAQEALRAGVPLIATAVGGLPGLVGDAAVLIPPGDVDALDQAVRELIADPGKRAAYAERGPRQAATWPSEQDTVLDVLAAYATVASSRAGQG
>NC_021191.1|WP_015623877.1|6716403_6718563_-|hypothetical-protein
MRGLLRRRWVPAVLILLSVVAALAGLSVRPTAGVSGRTADYVIVAGAAGLRWDDLDPQRTPALWHEATAGAIGWLSVRSAHATTCPTDGWLTLGAGNFSLWSTRAVSGACPALAPTVEQPDGIGANLPQLPGLVRANANQPYGAVPGALAETQRCTLAVGTGAAIAAARPFGRVDRYRPALPDDATGLFNQCRLNIVDLGTVTGSGAARQAQVAQADALLARVLAARPPSSLVMVAGVADTDRTSRLHVAIAEGPGWAPGWLTSAGTGREGYVQLVDLASTILTALGRPAPEELFGGRTATVDEDRPASPADSVLGRHDANQRAGAQLGVAGKFFLGLAAVQIALFVLCVPLMIRARRHAGPTGPASPSRLLVRITEVLMIAAALTIPAALLADAVPWWRAGRPGIVFAVLTFALVGLGTAAIRLSPRYGRTLWPLGLVAGVAVVVIAVDLLTGAQLQLNGVAGYSAIEGSRYAGLGGVGLGVFVAGALLAGGCLAQLVRRRWRPVVMAAIGAFAVVMVGNPYLGADQVGAVAVTAGVCVAAVISTGGWLTFPRFAWATVAGLAATISFAVLDLQRPEQERGSLGRFLAALLDGSAGPAMQRAAASSGHALDSPLTIMAVGGALMLAFSQFSAWGGLNRVFGLHPALRAGLGGTTVAVLAAGVLQGAGFAVAGAAAAVAVPLLVLTTLRVLEHAADRTRPDGETDGPGGPLLRRTDVMS
>NC_021191.1|WP_015623889.1|6729587_6729923_+|SCP2-sterol-binding-domain-containing-protein
MATVAECRSALQALAARLDANAETRGKLDFDRTLACRVTDLSTAFHARLAGGRLVDIADGDDPKAKIALTASSDDLIALVTGRLDVTRAIASRQVSVKANPFDLLKLRKLL
>NC_021191.1|WP_015623890.1|6729935_6730925_-|HAD-IIA-family-hydrolase
MSDRLVDGYDLVIFDLDGVVYLIDKPIEGAAEAVSQLRSDGTAIAYATNNASRRAADVAGLLNGMGVSAAPDEVLTSAGAAAARLADRVPAGAPVLVVGAEALRAEIRDVGLTPVERLEDKPVAVVQGFGPDVGWKILAEAALAVRAGALWVATNTDRTLPSPRGALPGNGSLVSVLRTALDREPDLVVGKPAPALFETAAALSSSRRPLAVGDRLDTDIEGAVGAGMDSLLVLTGVSGPAELLGAPESRRPTYVAADLSGLFAPVEAARIPLEGDEAGGWRLTDGRLDGSGSPVDALRLLAGFRWNGGEARAGSDEARALFEQWGLPA
>NC_021191.1|WP_051167837.1|6738827_6740066_-|tyrosine--tRNA-ligase
MQWRGLIQDSTDPDELRKHLDGGSITFYVGFDPTAPSLHVGNLMQVVTARRLQQAGHRPLLLVGGATGQIGDPSGRSSERTLNTQEVTAGWVQRIRDQLTPFMTFAGDNPATMVNNLDWTGELSVIDFLRDVGKHFPVNKMIARDVVRNRLETGISFTEFSYQLLQGNDFFELHSRHGCTLQFGGSDQWGNITAGVDFVRRRGAGPVQAFTTPLVLKADGTKFGKTAGGATWLDPTMTSPYAFYQFWVNADDRDVAQYLRYFSFKSRTEIEELEKATADRPQARLAQRELAYEMTALVHGKAEADQAVTASQALFGRGSLGDLSAGTLQAALSEAGMTTVTGELPPVAALLQQAGLAKSGGDARRTIAEGGAYLNNERITDPEAVVPEDALLHGRFLVLRKGKRTFAGVERV
>NC_021191.1|WP_015623895.1|6740137_6740878_+|hypothetical-protein
MSRLGSAAAPVQMSKKKAVEKLEEAQQRLLKLRLELGGQIGAKKIGPPLCVVFEGWDASGKGGAIKRLTAPLDPRHVRVSQFAAPTYDEKRHHFLWRFWPKLPGWGGMAVFDRSWYGRVLVERVEGFATREQWRRAYDEIVEFERTLTAEGMIMVKFWMHVSADEQLRRFEDRANDPLRTWKLTDEDWRNRKKRKVYEEAVEEMLKKTDHERAPWHVIPGDNKHYARLAVVDQVCAAIEKSYRVAE
>NC_021191.1|WP_041832644.1|6740859_6741456_-|class-I-SAM-dependent-methyltransferase
MTEHRQMAYLPAMGVRWLLPLYDPFCRLAGVSRIHEPLLDRAALHPGQRVLEIGCGTGTLLTACARRHPGIEAVGIDPDAAALRRARRKAARAGLSIRYEQAYAGDLPLPDASVDRVLSALMLHHLAEDERARALREVRRVLRPGGQLHLLDVTAPANPRTKPGNVLAAMAGAGLTGPTENGRGRARFGRVVFYSATR
>NC_021191.1|WP_041832645.1|6741468_6742401_+|AraC-family-transcriptional-regulator
MAGSDADSGGSVGMIRQSSVLVGRTGEGAPVYGFDRSPGSVPIVSARLPAAVPQPGIGPHAHDFLVLGYAERAAATVLVDGRKLGITDGDLFVLSPGQVIGLGDVPGLAVQGWVVWFPADVVRSGAYASWRSHPLLFPFARGSGRAQRLEVPPADRASWTAGFAALDAELRTRRDGYRDAALAHLMLLLVGVARLAVDVAGQLREANEPLLAAVFDVIERRYAEPISLADVAAELALTAGHLTTVVRRRTGRTVQQWITQRRLQEARALLSGTDLTVAAIGRRVGYPDAGYFIRRFRAEHRMTPARWREG
>NC_021191.1|WP_015623898.1|6742397_6743042_-|adenylate-kinase
MRKYVIMGVQGSGKGTQSQLLATGLDLVHISVGDIFRWNVQKHTKLGAQVRRAMSAGELVSDDLVESVVRDRLTMHDWNFGFIIDGFPRNARQAEFFMESYDIDGVIHLELPDDEVRRRVLSRRLCPGCGMDYNLIADRPEEEGRCDVCGTPLVVREDDTSEALTARLRDYHEKTRPVLELFRRKEYVYDIDARPSADEVQQHIRKALNLPPAG
>NC_021191.1|WP_015623899.1|6743046_6743595_-|hypothetical-protein
MVAFGGKQAWLAVRDGEPAALLDALDLRDLGEAGWRTGIDLAHLTDDRVVITPPLPGGWVLAVGRHLLVHQPPVDELSKVLQTEVQYFATHRVTETHKWQRAENGSLIRAFGYVGQTGDVTSWFGEPSAEERAAGLPGTVDDDTTVLVSEHDVFRVAGGWSIDPTTLTGPAPGPLRVGAWKG
>NC_021191.1|WP_157408546.1|6743633_6744146_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MGSTVRRVRKLLQSILSIGKRVSAPPARPPAPHAPTRQVPTQHVPTESRGRQIEYAPNLDGAADPGEVVWTWVQYEDDPHQGKDRPVLVVGRDGRTLLGLMLSSQSERDGQRNWLALGPGAWDREERPSWVRLDRVLEIDEDGIRREGAILDRARFTEVADTLRGKYGWA
>NC_021191.1|WP_157408912.1|6744162_6744966_+|endo-alpha-1,4-polygalactosaminidase
MRRCGVALAVTVALLLPYGRTAQAAPRSWWKPRASAALSWQIQFTGRVDLGVRADVFDLDGAATTRAQVTTLHKRGSKAICYVSAGSYEDWRADAAAFPPDVLGADLAGWPGEKWLDVRRWDVLGPIMRGRFQSCAAKGFDAVDPDNLDGYANANGLGLTAADQLTYNRRIAALAHGLGLAVGLKNDLDQVSRLVRAFDFAVNEQCAYYRECAELSPFVAAGKPVFEIEYEVATPVFCPAARKLGFTAIRKKQALSEWRQTCQSAAR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_15

6793542-6793620

Orphan

Consensus_repeat	Method
CCGTTCCGCCCGGCAGCACATCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_15

>merge|NC_021191|15|6793542-6793620|CRISPRCasFinder
CCGTTCCGCCCGGCAGCACATCCGCCGCATGCATCGCTCCACCACCGGAAAGTCCGTTCCGCCCGGCAGCACATCCGCC

>NC_021191|15|14|6793542-6793620|CRISPRCasFinder
CCGTTCCGCCCGGCAGCACATCCGCC	GCATGCATCGCTCCACCACCGGAAAGT
CCGTTCCGCCCGGCAGCACATCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015623951.1\|6789220_6791518_+\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|376383
NC_021191.1\|WP_015623945.1\|6784087_6785416_+\|ATP-dependent-6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235869
NC_021191.1\|WP_157408914.1\|6794259_6796104_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224037
NC_021191.1\|WP_015623955.1\|6797541_6797844_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NC_021191.1\|WP_015623948.1\|6787653_6788196_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224059
NC_021191.1\|WP_015623962.1\|6801732_6804213_-\|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234804
NC_021191.1\|WP_015623950.1\|6788765_6789110_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_041834162.1\|6805469_6806321_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NC_021191.1\|WP_084504301.1\|6788221_6788578_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225107
NC_021191.1\|WP_041832650.1\|6791596_6793063_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349894
NC_021191.1\|WP_041832649.1\|6786085_6786778_+\|membrane-protein	unknown	unknown	gnl\|CDD\|225500
NC_021191.1\|WP_015623965.1\|6806355_6806748_-\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959
NC_021191.1\|WP_015623957.1\|6797856_6798447_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NC_021191.1\|WP_015623953.1\|6793338_6793476_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_157408551.1\|6786680_6787625_+\|serine-hydrolase	unknown	unknown	gnl\|CDD\|379138
NC_021191.1\|WP_015623961.1\|6800989_6801685_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187585
NC_021191.1\|WP_084504589.1\|6785373_6786027_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225928
NC_021191.1\|WP_015623959.1\|6799572_6799722_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015623958.1\|6798677_6799451_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376645
NC_021191.1\|WP_041832651.1\|6804215_6805277_-\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015623951.1\|6789220_6791518_+\|glycoside-hydrolase	gnl\|CDD\|376383	pfam00759, Glyco_hydro_9, Glycosyl hydrolase family 9.	7.28713e-170
NC_021191.1\|WP_015623945.1\|6784087_6785416_+\|ATP-dependent-6-phosphofructokinase	gnl\|CDD\|235869	PRK06830, PRK06830, ATP-dependent 6-phosphofructokinase.	0
NC_021191.1\|WP_157408914.1\|6794259_6796104_-\|hypothetical-protein	gnl\|CDD\|224037	COG1112, COG1112, Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair].	6.72078e-35
NC_021191.1\|WP_015623955.1\|6797541_6797844_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	1.47944e-16
NC_021191.1\|WP_084504589.1\|6785373_6786027_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225928	COG3393, COG3393, Predicted acetyltransferase [General function prediction only].	1.97306e-12
NC_021191.1\|WP_015623962.1\|6801732_6804213_-\|phenylalanine--tRNA-ligase-subunit-beta	gnl\|CDD\|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	0
NC_021191.1\|WP_041834162.1\|6805469_6806321_-\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	6.40973e-62
NC_021191.1\|WP_084504301.1\|6788221_6788578_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.83637e-08
NC_021191.1\|WP_041832650.1\|6791596_6793063_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349894	cd05642, M28_like, M28 Zn-peptidase-like; uncharacterized subfamily. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions.	0
NC_021191.1\|WP_041832649.1\|6786085_6786778_+\|membrane-protein	gnl\|CDD\|225500	COG2949, SanA, Uncharacterized membrane protein [Function unknown].	1.71638e-49
NC_021191.1\|WP_015623965.1\|6806355_6806748_-\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	3.50573e-60
NC_021191.1\|WP_015623957.1\|6797856_6798447_-\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	8.78371e-45
NC_021191.1\|WP_015623948.1\|6787653_6788196_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	4.78652e-42
NC_021191.1\|WP_157408551.1\|6786680_6787625_+\|serine-hydrolase	gnl\|CDD\|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.50896e-25
NC_021191.1\|WP_015623961.1\|6800989_6801685_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187585	cd05324, carb_red_PTCR-like_SDR_c, Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs. PTCR is a classical SDR which catalyzes the NADPH-dependent reduction of ketones on steroids and prostaglandins. Unlike most SDRs, PTCR functions as a monomer. This subgroup also includes human carbonyl reductase 1 (CBR1) and CBR3. CBR1 is an NADPH-dependent SDR with broad substrate specificity and may be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds. In addition it includes poppy NADPH-dependent salutaridine reductase which catalyzes the stereospecific reduction of salutaridine to 7(S)-salutaridinol in the biosynthesis of morphine, and Arabidopsis SDR1,a menthone reductase, which catalyzes the reduction of menthone to neomenthol, a compound with antimicrobial activity; SDR1 can also carry out neomenthol oxidation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.37311e-75
NC_021191.1\|WP_015623958.1\|6798677_6799451_+\|hypothetical-protein	gnl\|CDD\|376645	pfam01887, SAM_adeno_trans, S-adenosyl-l-methionine hydroxide adenosyltransferase. This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme. S-adenosyl-l-methionine hydroxide adenosyltransferases utilizes a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion. This family used to be known as DUF62.	7.41927e-07
NC_021191.1\|WP_041832651.1\|6804215_6805277_-\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0

>NC_021191.1|WP_015623953.1|6793338_6793476_-|hypothetical-protein
MSSAANDADCTAEIAGASFRIVAQMSPGRWTPSQQPISIAGLPDP
>NC_021191.1|WP_041832650.1|6791596_6793063_+|M20/M25/M40-family-metallo-hydrolase
MTDRCDRSQASRSQPSRRTFLSASAAAALSASAGVAATPASAATAPASAGSRGAGEGANGLPKQVPDVQLRALLREIDPHRIETIVRRLAAFGTRHTLSSQDDPVRGIGAARDWILEQFQTYAAASGGRMTVELQSYIQPPASRIPAPTRISNIVATLHGTDEPGRVYVVTGHYDSRATDVMDAGSDAPGADDDASGVAAVMEVARVMATRRVQATIVFAAVAGEEQGLYGSDHLAQQLKNANTDVQAMFSNDIVGTGDAHDGTAAAPRTVRLFVEGVPTAETPAQASTRLSVGGENDGPSRQLGRFVQDVAENPQTGMDVRVIWRRDRYLRGSDHISFLLRGYPAARFTEPRENFAHEHQNVRVENGVQYGDLVEFCDFRYIARVARVNAAALWSLAQAPGTPQGVVIDTTQLTNQTTLRWQPSPATDIAGYEILWRETTAPDWQHVRAVGNVTTTTIDLSKDNVFFGVRAVDRDGHRSPVAAPMPG
>NC_021191.1|WP_015623951.1|6789220_6791518_+|glycoside-hydrolase
MKKLLVVLTALLLLPLAAPAQAAPAYSYGEALQKSLFFYEAQISGKKPAWSRVSWRGDSALSDGADVGLDLTGGWFDAGDHVKFGLPMAFTTTMLAWGAVENRAAYESSGQLTYLLNNLRVPNDYFIKAHPSPTVLYGQVGKGDDDHKWWGPAEVLPMARPAYKIDASCGGSELAAETAAAMAASSMVFRPTDPAYADTLLTHAKQLYTFADTVRKSYHECITDATAFYRSWSGYADELVWGAIWLHRATGDAAYLAKAEAGYDAQGNEPQTATKMYKWTLSWDNKQYATYVLLAQLTGKQKYLDDANRWLDWFTVGVNGEKVRTSPGGMVVVDSWGALRYAANTAFVALVHSDHIADATRKQRYHDFAVRQINYALGDNPRRSSYVIGFGANSPKNPHHRTAHGSWWDSMQVPEQTRHVLYGALVGGPSAPDDAYTDSRSDYVMNEVATDYNAGFTSALARLYGEYGGAPLSGFPVAEKPDQPELSVETTIMQNETRSTGVKAIIYNKSAFPARALTAGKFRYYFTRDDASPLVVSSPYTQGCPGPTAAKQYSGNIWYVEVDCTGYKIAPAGQSAYRMEVQLKIGVAEGGTWNPANDPSYQAASGPNATVPLWDGSTLVWGSLPGTGGPAPSDPPSSSPSPSQSPSPSPSQSPSPSPSAPSGCRVGYVTNDWSNGFTATVTVTNGPVAVNGWTLTFAYPGGQQVTQAWSATVTQTGTQVTAANLAWNGALAAGASVSFGFSGTHPGTNPRPASFALNGTPCASS
>NC_021191.1|WP_015623950.1|6788765_6789110_+|hypothetical-protein
MTATSRSTTATGTFDHARTAGYADATEAHHARPRGDETKPSWKTTELFVYLAAVAGVLIASQVTGDGPAENGGDFFAADKAWWYITLLTIGYLVSRGLAKAGVRTRDADPRSTR
>NC_021191.1|WP_084504301.1|6788221_6788578_+|helix-turn-helix-transcriptional-regulator
MGLPRPGGHPGAGRGAGDHRAGPDRVVRRRPARRFRPRRLRRDLHHLVHLSGAARRRGHHEILGLLAEGRSNVAIAETLRLAGRSVEKHVTAIFTKLDLPQDCSDHRRVLAVLRYLRA
>NC_021191.1|WP_015623948.1|6787653_6788196_+|ATP-binding-cassette-domain-containing-protein
MCRGPRPARLIRMESVISLTAVARRYPRGVLALRDVSLEIPAGHVALPRRLGGPRARSVDDVLAQVGLPGLGRRPVGELSGGQQQRVAIARALVTAPSVIFADEPTGALDPGTGARILGLLRAAADRDRVTVLMVTHDPVAAAWSDRLVLLRDGTVVDDRPAPDAAGIAERLRGVSAVPA
>NC_021191.1|WP_157408551.1|6786680_6787625_+|serine-hydrolase
MPWSRRCSTSSPAATRCSSARTRPAWTRQQQGDQVIAAGYAEQKARAGGTWHSLITGADGTVLVDDDADRVVHGYSVQKLAVATAVLDRVPLDTRVTLRAADVLGGSGSYHLQGVWGDSVTIAGVLTAMLLVSDNTAVRLCGSVLPAAAINEVLAAKGFTHTRVEPVADPHRFLLGTTTARETHELLRGLATGTLLPAPACAFLLAVLRGSSGYHDGVRRSMSSAERARVATKHGADFDARGAARHEAGIMSGPGPQPGPEPGPGPEPGPGPPGVWPVTYAMFADGLGDVHNYGATHPAVEAHAVIGRALLGCG
>NC_021191.1|WP_041832649.1|6786085_6786778_+|membrane-protein
MLTAVTIPSRMIIWLRRLVLLGSLGVAASVLAMAAGDLWVRAAASGHVYEESTVPAAPVALVLGAEVYPDGSPSPFLAARLEIARQLLADGKVKAILVSGDHREWDYNEPGAMYEWLHQHGVPSERIVLDHAGFDTYDSCARAKRIFGVTALTVVTQSYHIDRAVTVCRDVGIEANGVADDSVRIYREPWYHSVVRERGAVVKAMLDVVSRRDPVFLGPHETGVDQATAG
>NC_021191.1|WP_084504589.1|6785373_6786027_-|GNAT-family-N-acetyltransferase
MLVWAAQDMQPGSRAWALGDAAAVARHRVANRDRLAVRGNPGDLDRLLRRIRPEVSDLFPVGDEELIKATPGLAVVACFGWMDTTTPVPGAAADLVRVADDEVAAFLDAHHPHSFARPGWPGVPTWLGLRDDAGELQAVATDAWTTSRLGFISGVATRTDLRGRGLATRLCSALTNELLRGRERVALLVDHDNTAAVRTYERLGYAKRRIAAAKFAG
>NC_021191.1|WP_015623945.1|6784087_6785416_+|ATP-dependent-6-phosphofructokinase
MIDPAQLQVRTLGEGRITSPLDALIPAHGSTQHYVDEGDRVLFDDTQAMLAARTGGELPSFEPGGARRRIFFDPSKIRVGIVTCGGLCPGLNDVIRGLVLTLNNQYGVSRIIGFRNGYQGLVPRHGRSIVELTPESVEYVNEHGGTILGTSRGNQDPDEIVDCLEQLGVNILFVIGGDGSMRGALRISEVVAARERRIAVVGVPKTIDNDIPYIGQSFGFQTAFAKAAESIRAAHVEAAAQPGGIGLVQLMGRHSGFIASYAALANNDADYVLIPEVPFSLDGFLPDLRHRVATRGHALVVVAEGAGQEHLEEAPVRLDASGNRKLGDFGLFLRERILADFAQAGQEVNLKYIDPSYAIRSVPANPYDSVYCLRLAQAAVHAAMAGRTEMVVGQWRGRFVHVPIPLAVSARNQVDPDGDLWLSVLEATGQPANFAAAIRRLA
>NC_021191.1|WP_157408914.1|6794259_6796104_-|hypothetical-protein
MGDSPPASGRFPLAADRPSMLEDHAAAAGSAGRSAVPLAGAPAPGPMAGGLTRDSESPSVVPGAAAVPGGQSSAGTELSGGVAVAGGASAGPGGSSAGPVGDTGGSEARGGPFGGAEHQPGGLSFADELAAAGAGDRVRAALRAARTRRAAARLAAAGGATDATSQWAALHQAEAALAQAVGTAMRRAVRSRKRWDTDARRGAAALATALRAGRNRRRELLSRMDAEPLVRALPLWIGTVGDVEDLLPATPGMFDLVVLDEASHVDQIRAAPVLARARRALVVGDPRQLRFVSFVSDVDVAEVLDRHGADDRLDVRRVSAYDLAAGAAPATWLDEHHRSAPHLIGFPARRFYDDRVTVATRHPRTEATDAIDIVRVPSPADEVGAVVDVVRQVAASGRTGIGVVSPFRPQADALEQALLAAFPAERIEQLGLRVGTVHAFQGSEADTVVASLGLADGDPAGRRRFVTDPHLFNVMITRARRRLVVVTALTSPDGLLGDFFGWADKPPEPALAADPPGWAGALTSELRKMRVTVRPGYAVGSWTVDLCAGPPDNALGIFCAVHPDGPAAHIARHRALRRAGWHLADILPADWHHDARRAALEIAAHLAQPAPPLP
>NC_021191.1|WP_015623955.1|6797541_6797844_+|antibiotic-biosynthesis-monooxygenase
MAYGCVNTMRTTAGHRDEVVQILLSGADGLKEAGCQLYVVSVSPTDADVIVVSEVWDSKQHHDDSLQLPEARAAIAQAMPMLTGEFATQELEVVGGLGVD
>NC_021191.1|WP_015623957.1|6797856_6798447_-|DinB-family-protein
MTEPDAKADLHHYLQSAREALLWKLDDLSEYDVRRPLTPTGTNLLGLVKHVALTETGYLGESFGRPIADQPAGMEADAEANADMWATAAESRDEVVDFYRRVWAHDDATIEALPLDAYGEVPWWPAESRRVPLHRVLVHVIAETHRHVGHADIVRELVDGATGMRRQATNMPPGDQAWWQGYTSTLQRTAEKFRDA
>NC_021191.1|WP_015623958.1|6798677_6799451_+|hypothetical-protein
MLLTIVADYGTGDLAFAEVRQRIAGLLPEADVAAIPVPAFDTVSAGFCVAQLGFGAGPADRVIYANVAPRQDEDEPRADNAGERLVAARLPSGVLVVGVAAGASLSFLADAGVPLRAVRVADAGSQFRSRDVFPEAVAGLVRGDNNLLGDPVTVAPAPDRSVIYTDGYGNLKTSWYEPPAPTGATVQVRIGDARAEAMVSDGVFTVPPGTISFAPGSSGWPAADGTPRACFELFARGGNAAEIFGNPPAGTAIEMVS
>NC_021191.1|WP_015623959.1|6799572_6799722_+|hypothetical-protein
MAGNRVTVAGSMAGSRVTVAGSVAGSRVTAAGGSRAAWLAVAGAWLAAG
>NC_021191.1|WP_015623961.1|6800989_6801685_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTITFITGANKGLGFETARRLSELGHTVLLGARDPELGRAAAATINARFVRIDVTDDASVAAAAADVEQHEGAVDVLVNNAGIHGPAGDPSSLTGADVLGVFDVNVAGVVRTTTAFLPLLRRSADPVIINVSSGMGDLEATHDRSRPEGNYVAPVYTASKAALTMLTTQYAKALPEMRINAADPGYTATEFNGHSGPQTVTEGTDAIVQLATEGPGHGSGRFVERHGEKSW
>NC_021191.1|WP_015623962.1|6801732_6804213_-|phenylalanine--tRNA-ligase-subunit-beta
MKLSLSWLREYVELPAGLDPAELERRLVDLGIEVESVVDQAATIKGGLVVGRVLQIEELTGFKKPIRFCHVDVGNADPQEIVCGARNFAVGDLVVVILPGGELPGGFQIASRKTYGRVSNGMICSAAELGLGTDHDGIVVLPPDAAAPGADARPVIGLDDVVVEVEITPDRGYQMSVRGLARELSHTFAAAYTDPGHGAALVPTAEPPYEVRVDDTVGCDRFAAAVVRGIDPAKPSPDFMRRRLATAGIRSISLAVDITNYVMLELGQPMHVFDLNRLRGGLVVRRAHPGEKLTTLDGVARVLDAEDMVICDDSGPVSLAAVMGGETSEYQPDTVDVLLEAAHWDPVMVGRTARRHKLFSEAAKRWERGVDPQLALVALHRAVELLTTYAGGTADERVLDIDTVVAPAAIGLPTDLATRRIGVPYGVDQLDELLTMIGCTLTGVEPLEVTPPTWRPDLVAPIDLVEEVARLGGYDAIPSILPPARDGGGLTPQQIRRRMVGRALAEHGYVEVLSYPFVAPGAADAFGLPADDPRRSAVRLTNPLSEQEPLLRTSLLPPLLTTLKRNLGRGERDLALYELGTVFQPHLTTTAPPVLGVDHGPSEPDWAAANAIVPTQPWHLAVALTGDLVPAGWWGEGRAATWADAIEAARTAIAAAGISTDRVSVQAAAYAPWHPGRCAAISVDGQLVGHAGELHPAVLSTLELPKRTCAMELDLDALPVKPVAEAPAISTFPPALIDVALVVEQSVPAAVVQDALVAGAGPLLESVRLFDVYESAAQLGEGRKSLAYKLTFRAPDRTLKAEEAVAARDAAVTEAAARTGAALRGA
>NC_021191.1|WP_041832651.1|6804215_6805277_-|phenylalanine--tRNA-ligase-subunit-alpha
MSYRNDPYDPKQAALLDPSALEAAVAEAEAAFAAAGDLDALGALKPAHLGDRSPVSLARREIGSLPPAAKSDAGKRVNEARQAVQAAFDARQAVLERERAERVLVEERVDVTLPWERHPRGARHPLTTLMEHMGDLFLGMGYTIVDGPELELEWANFDALNIGPDHPARGLMDTFYVDLPGLVMRTHTSPGQVRTMLTRQPPIHVVSPGRAYRTDELDATHSPVFHQIEGLVVDEGITMAHLKGTLDHFAKAMFGPDARTRWRPHYFPFTEPSAEFDVWFAQHRDGPRWVEWGGCGMVNPRVLTACGIDPERYSGFAFGIGVERTLMFRNGVSDMHDMVEGDVRFTRNFGMAV
>NC_021191.1|WP_041834162.1|6805469_6806321_-|RNA-methyltransferase
MPAGGVPAFPEGLPVTFTPRTPRVVAARRLQRRRDRDKTGRFLAEGPQAVRSALAAGVVLDLFGTEEALARHGDLASQAPEVSPVTVEALAGLAETVQPQGLVAVCEQVDVPLAEALAKRPRLVAVAVAVRDPGNAGTILRTADAAGAGAVIFAGDAVDPYNGKCVRSSAGSLFNVDVVRAPHVTVSDLPGLRVLATTGYGDTDLDQLLDDGSLGRPTAWLFGSEAHGLGADLLEAADARVRVPIYGGAESLNLAAAAAVCLYASARAQRSSVTPGVDHESAV
>NC_021191.1|WP_015623965.1|6806355_6806748_-|50S-ribosomal-protein-L20
MARVKRAVNAQKKRRTLLETASGYRGQRSRLYRKAKEQVLHSMQYSYRDRRDRKGDFRQLWITRINAGARANGLTYNRLIQGLKLAGVEVDRKILADLAVNDAASFAAIVEIARAAVAAEGTGGAAAQAA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_16

7168648-7168749

Orphan

Consensus_repeat	Method
CCGTCCCTCGACCCGCCGCCAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_16

>merge|NC_021191|16|7168648-7168749|CRISPRCasFinder
CCATTCCTCCACCCGTAGCCACCGCCAGCCGTCCCTCGACCCGCCGCCAGCCCATCCCTCCATCCACCGTTGCCGCCAACCGTCCCTCGACCGGCCGCCAGC

>NC_021191|16|15|7168648-7168749|CRISPRCasFinder
CCATTCCTCCACCCGTAGCCACC	GCCAGCCGTCCCTCGACCCGCCGCCAGCCCATCCCTCCATCCACCGTTGCCGCCAA
CCGTCCCTCGACCGGCCGCCAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015624321.1\|7151756_7153814_-\|type-IIA-DNA-topoisomerase-subunit-B	unknown	unknown	gnl\|CDD\|235501
NC_021191.1\|WP_041832696.1\|7177997_7178546_+\|LytR-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|379163
NC_021191.1\|WP_015624335.1\|7176746_7177898_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_021191.1\|WP_084504314.1\|7153904_7159157_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|270916
NC_021191.1\|WP_015624328.1\|7165804_7166485_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_021191.1\|WP_041832692.1\|7160015_7162832_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226415
NC_021191.1\|WP_015624337.1\|7178611_7179712_-\|ionic-transporter-integral-membrane-protein	unknown	unknown	gnl\|CDD\|223464
NC_021191.1\|WP_041832695.1\|7175808_7176315_-\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|376622
NC_021191.1\|WP_015624340.1\|7183619_7183832_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_041832693.1\|7167327_7167813_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380121
NC_021191.1\|WP_051167615.1\|7164480_7165812_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NC_021191.1\|WP_015624323.1\|7159197_7159848_-\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NC_021191.1\|WP_015624339.1\|7180817_7183610_+\|SWIM-zinc-finger-family-protein	unknown	unknown	unknown
NC_021191.1\|WP_015624338.1\|7179780_7180785_+\|glutathione-transferase	unknown	unknown	gnl\|CDD\|223512
NC_021191.1\|WP_157408927.1\|7168908_7171971_-\|coagulation-factor-5/8-type-domain-protein	unknown	unknown	gnl\|CDD\|185691
NC_021191.1\|WP_041832694.1\|7168107_7168524_-\|glyoxalase/bleomycin-resistance/dioxygenase-family-protein	unknown	unknown	gnl\|CDD\|319925
NC_021191.1\|WP_015624332.1\|7173007_7173616_+\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|367619
NC_021191.1\|WP_041834220.1\|7162997_7163771_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_157408582.1\|7163914_7164439_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_021191.1\|WP_015624333.1\|7173719_7175114_-\|DUF1996-domain-containing-protein	unknown	unknown	gnl\|CDD\|370451

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015624321.1\|7151756_7153814_-\|type-IIA-DNA-topoisomerase-subunit-B	gnl\|CDD\|235501	PRK05559, PRK05559, DNA topoisomerase IV subunit B; Reviewed.	0
NC_021191.1\|WP_041832696.1\|7177997_7178546_+\|LytR-C-terminal-domain-containing-protein	gnl\|CDD\|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	2.69479e-12
NC_021191.1\|WP_015624335.1\|7176746_7177898_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.22651e-96
NC_021191.1\|WP_084504314.1\|7153904_7159157_-\|diguanylate-cyclase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.43237e-79
NC_021191.1\|WP_015624328.1\|7165804_7166485_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.45874e-79
NC_021191.1\|WP_041832692.1\|7160015_7162832_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	3.08676e-23
NC_021191.1\|WP_041832695.1\|7175808_7176315_-\|hemerythrin-domain-containing-protein	gnl\|CDD\|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	6.48191e-11
NC_021191.1\|WP_041832693.1\|7167327_7167813_+\|hypothetical-protein	gnl\|CDD\|380121	pfam18143, HAD_SAK_2, HAD domain in Swiss Army Knife RNA repair proteins. Family of HAD domain phophoesterases observed in large eukaryotic proteins with predicted role in RNA repair, the so-called 'Swiss Army Knife' repair proteins. May be involved in phosphate group removal during RNA re-ligation.	0.0006924
NC_021191.1\|WP_051167615.1\|7164480_7165812_-\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.51658e-44
NC_021191.1\|WP_015624323.1\|7159197_7159848_-\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	2.38787e-39
NC_021191.1\|WP_015624338.1\|7179780_7180785_+\|glutathione-transferase	gnl\|CDD\|223512	COG0435, ECM4, Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	4.55005e-145
NC_021191.1\|WP_157408927.1\|7168908_7171971_-\|coagulation-factor-5/8-type-domain-protein	gnl\|CDD\|185691	cd02182, GH16_Strep_laminarinase_like, Streptomyces laminarinase-like, member of glycosyl hydrolase family 16. Proteins similar to Streptomyces sioyaensis beta-1,3-glucanase (laminarinase) present in Actinomycetales as well as Peziomycotina. Laminarinases belong to glycosyl hydrolase family 16 and hydrolyze the glycosidic bond of the 1,3-beta-linked glucan, a major component of fungal and plant cell walls and the structural and storage polysaccharides (laminarin) of marine macro-algae. Members of the GH16 family have a conserved jelly roll fold with an active site channel.	1.76791e-100
NC_021191.1\|WP_041832694.1\|7168107_7168524_-\|glyoxalase/bleomycin-resistance/dioxygenase-family-protein	gnl\|CDD\|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	5.05502e-11
NC_021191.1\|WP_015624332.1\|7173007_7173616_+\|DUF305-domain-containing-protein	gnl\|CDD\|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	1.59508e-11
NC_021191.1\|WP_015624333.1\|7173719_7175114_-\|DUF1996-domain-containing-protein	gnl\|CDD\|370451	pfam09362, DUF1996, Domain of unknown function (DUF1996). This family of proteins are functionally uncharacterized.	1.46988e-54
NC_021191.1\|WP_157408582.1\|7163914_7164439_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000685779
NC_021191.1\|WP_015624337.1\|7178611_7179712_-\|ionic-transporter-integral-membrane-protein	gnl\|CDD\|223464	COG0387, ChaA, Ca2+/H+ antiporter [Inorganic ion transport and metabolism].	1.89486e-75

>NC_021191.1|WP_041832694.1|7168107_7168524_-|glyoxalase/bleomycin-resistance/dioxygenase-family-protein
MSTFRTPQVILFSEDLPRAVAFYRQLGFTEAFQVPAEGEPIHVDLALDGYKIGFASAASTRADHGLAPVTEGQRAAVVLWTDDTATAYASLVESGAPALAAPHKWLDRLLIAWTADPDGNPIQIVQPMAASQDGASNA
>NC_021191.1|WP_041832693.1|7167327_7167813_+|hypothetical-protein
MERVNRPVMLLDLDGVLNPFGASTCPEGYVEHEFFPGEGLERYCPAHGEWIRELAAAGDLYWASAWGEDANTLLAPLLGIDSLPVIPFPPVPFPPERKVPVIAEAVGDRPVAWIDDNHTDAGRRWAAERAAPTLLVPVDAATGWNRDDVDKVLAWSRQLGA
>NC_021191.1|WP_015624328.1|7165804_7166485_-|response-regulator-transcription-factor
MGDKGLVLVVEDERPIADLVRLYLARDGFGVQVEHDGVAGLAAARKMRPVACILDIALPGMEGTEVCRRLREDGDWTPVVFLTARDDEVDRIVGLELGGDDYVTKPFSPRELVARLRALLRRAAGPGEGERVKTLGDVVLDPARRVVTVAGVPLNLTPTEFDLLGHLLGRPGRVFTRDELLAGVWGYASHAGTRTVDVHVAQVRAKLGSAAGLIRTVRGVGYTADA
>NC_021191.1|WP_051167615.1|7164480_7165812_-|HAMP-domain-containing-protein
MLRTFSGRAVLVTAATAVVSVIITALVALPIAVRSANSAARADLVEKSALAVELLATERPVARERIVTRLRDDGIAVYLLRQGVPDRPGLPERVVGAVAAGSVVSSTGVVDGRAVLIAGRPLSGNDAGVVLTRPAVSGTAARVLGGVWVALLAGLLGGVGAGALLAHFVTRPLRQAALAAARLSAGDRSVRLAVRAPAEAAELASALNRLGAALQISEGREREFLLSVSHELRTPLATIRGYAEALADGVVTADSAAQTMLGEAERLDRLISDLLVLSRLEAADLPVDVVAVDLADLVATAGEAWAPRCSPDGPVLTVEVPAQPVMVDTDPGRIRQVVDGLCENALRVVPAGAPLVLAVRAGERGGVVEIRDGGPGLTDEDLAVAFQRGALQQRYRHVRKTGSGLGLALAARLVTRLGGTIEAGHAPEGGAMFTITVPYTTRT
>NC_021191.1|WP_157408582.1|7163914_7164439_-|hypothetical-protein
MKRIALSLGVAGLLALTACGTTTTPADLADDMSALTAVGFSESTPQPGASGAPDAAAKDKAAPKDKAAPKDKAAPKDKAAPKDKAGRSYLRKNTLHGEVTVQGKKGARTVVVQRGTVTATDAKTVSVKSADGFTQTWTLGDPVTVKGKLATGAEVGVAGRKDGSTVMARLIRVK
>NC_021191.1|WP_041834220.1|7162997_7163771_+|hypothetical-protein
MTEASVWGPVQRDMADVLAGHPDDVPSVVGQLTALQDILVRVPPLLHSNPLADFNKLYLTITTCVLEGLYEGRFADPAFLARLDVEFAARYFDALRQWSDMSAGCPRAWLILFHRIPGPDARPLPSAAAGVNAHINYDLPFALVTTFDHQGCDPVDDTDQHHDYLEINDIFAEQIPGLRRGFLEKWQLLIDMMNGDLDDWWQGELVEYTRNVAWRNAQKLWGVRHDLQAVGRERARLDRTAESLGKLLLSPMGSILQ
>NC_021191.1|WP_041832692.1|7160015_7162832_+|LuxR-family-transcriptional-regulator
MASERDDAPLVGRSGIVTTVQSGLLGAGPGGTAAVFVTGESGVGKSRLLRETAEALEAGGTAVLSGICLDIGDASPLHPVLQALRLAGAQPEPATTPSADGAGALLEQVSHQLRSLARGRRLLLVLDDLQWADRSTRQLLLYLLAGLGGISLSVLAAVRSESLHGSHPLRRVLAELRRLRSVQVLDLAPLDRAATAELVTAIAGEDVTEEDAARVHKRSGGNPFVAEELARDLRDGRVELSDTLREIFLSRVDELPAHAHEVVHTIAAGIEPVEHALLARVLPLPETDLLEAVRAAVAHRFVTSATDGYRLRHRVVAEVLEHEILPAEHAARHRRYAEAIEALPGDPDHARLAHHWQQAGEPGRALPSVVAAARTAEQLYGFTEAYRHWSLALTLTGEADPGRTELLGRAAEAAHRCGEHQRALSTLEQLAARPDGPGSCELHLRRARYLAAAGRTATAETEYERVLAADACTPQEKATAAAHLAELLVHLGRYADAGDRARDALELAGNSKNATPDLVRASAALGFSLAFLQDPDAGLAVIRQAVEIAERSGHPDDIGIAYQHLAELLANPLNMVEEGVLAARRGAEKLAAIGQGRSCQTRLLAIAANGLFRIGQWTEMERVLDEAMRHRPSGADAVEILLARCRLWVGVGDFEAGTRDLDAVATILAGGGARHVLPMLTLRAGLAMWLGRPAEARAAVQRGLTETRSDDLVLLGVLAWHGLRAEAEAQAGGEEPVDPTAVRRLRAIVERMARGVGSAAPQVRAVVDGYLDLCTAEISRVEQRSDPDLWARSAAAWDRRSQPYPAAYSRLRQAEALFARRARKATASMALREAYATARAMGAKPFAAEIEQVAARARVTLADAPEATGSTMPQGELALLTEREREVLAALAEGLTNREIGQALFISERTVGVHVGHIFDKLQVRTRVQASRVYLGAA
>NC_021191.1|WP_015624323.1|7159197_7159848_-|adenylate/guanylate-cyclase-domain-containing-protein
MSAGPTEVMCRRQTVTILFVDIVGFTTLVDELDCADVHDLQREYFAAVSAVLRAAGGIVEKFIGDAVMAVFGTAGPDAGTPPEVANAAAAAARAGLLVQEALRGRLLAGRHPIKTRVGLATGDAMVDPAAQDGGYGMVSGSVVATASRLQAYAPHDTVVVCAATQQASAEAVAYQELPPVSVHGKRAPVELWRALHPRAATFRDDVVTQRALHPCR
>NC_021191.1|WP_084504314.1|7153904_7159157_-|diguanylate-cyclase
MGASPSVPTEPAAVQWEPGADAGLEVLAEIGRGAQAVVCRARHDGTEYALKVLLTDDLRPEQLREFRRQAALLASIDHPGLPRVHRAGAAGGRPYLVMDLVDGESLARRLLRGPLAERDAIAIGIGLAEALRPAHRRDLVHRDLKPENVLITGAGEPRLVDFGLATGPTGSPLGPDDAIAGTLTYCSPEQAGMLNRPVDARSDLYALGAVLFECVTGAPPFAADDVGELLHLHATAPVPDPRALAPGLGATFAAILVRLLAKDPDDRFQSAAGLAADLRRLATDPAAVFPLGDDDVPEAPHEPAMTGRDTEFETLRARWEDARQGTGGLVLLHGPTGVGKTRLATEIGTFAASTGGVVLRGGASSSDRRPMGPLRAAVDTYVRDLLRAPGGRESAAQTLRTAAGESAGLVTSLSPALADLLGVAQVSGEVGFGRHAAAVADLIAGLARTAGPLLLHLDDAQWYDEGTVRVLEQLAARAADLPLLLVATLRQDDAKPSPVLPRLTAAGPATELTLGAFGPAEVGGLIAALSGGIRTSEPSNTMIALLTGGNPFVTLGYARAVMDAGLLTPDWGTWQVDPDGVRDLALPADAAQLVLRRLGGLDAESRRLLAVAAVTGTSFDASIVAEAAGVERRRALDLLADAARQGIVELRAGRHRFVHETIRTALLAELDAVAVRELHGAIAAALDAAPDPDVYELARHCSKSDPALDPHRTLRVCTEAGARALAEHAPDTALTYLEFARAAAQTAEIRLGSRFKQLLGSAYHQNGRLDAAAATLTGALAETTDHVERAGIQLLLARVHESDWNGAAQQHAVEQGLAELGRTLPARRLWRVTTSFWICIIGGLCRLTGLGYGTARGKRRELLRLETTLHHYGITGSLRDLRPRRALLHALRTVHPVNRLGRSPERARDLVALGVALRLLGLPRYAGRVTAAGLRLAAELGDPTLTARIEWMHAMGLHGSGADSGERIRRVLHERERFLDAGPVLDCYAVLGWDLLLRGECAAAEAAADARRGWLAAYGHTGRATMVALDAALLALRGRAGEAIAELNRADAGPRSRNEVVDTIMVRMFSAIERDDLGSAFDDAVAEFEGLELAPRDMLPVHHGFYVYQAYGRLEQARRAAPAEQERALRAAAAAVTALGRVTRRPLIAAHHQIARAALAVLTPGGAAAALTLLAEGEDLLRTVDAPLPAFEAALVRARALAATGVPGEAERQARLAAGIAEERGWTHRARRTGAEFRIDAGRRNRVPVAAVRGREGQRWAALEQLSNAASRVIDPERLTRVALDETVRLLGAERAMLFLADSAKGRLTPYVGRDAAGRDLAELTGYSTTVVGKVRQTREPLVVTGTEEGAALGAASVVQYGLRSMLVAPLELDDRLLGVVYLDSRVAKGVFTVDDVDVLTAITHHIAVGLETARAAQLEVAVAAANRQRDLAETLRRAMARLTGTLDPELVLRRLLLTARQTPGGERGWLLLGTPESPEVTVLGGSAGPGSIVLAEYPELRKLFENRQADLTAGTPAWAAALGDYTGASWLTVTLDDREGMVGVLVLASEQEGVYTAAELGVAAALVSQGMVAYDNARLFSRINELATTDSLTGVANRRRFFELAERSVTAAQDARRPVTALMIDIDHFKRINDSYGHQTGDDVIKGVVARVLTCIPSDGLVSRYGGEEFAVLLPGVADDGPAIAEKVRAAVDGAPIETRTGDIPVTISVGFSRLRSADTTPDALLGRADAGLYEAKQAGRNRVMAHDE
>NC_021191.1|WP_015624321.1|7151756_7153814_-|type-IIA-DNA-topoisomerase-subunit-B
MTAQQEILYGADDLTHLEGLDAVRKRPGMYIGSTDSRGVNHLANEIIDNSTDEGVAGHAQHVAVVLHPDGSVQVDDDGRGIPTDINAKSGLSGVELVLTRLHAGGKFGGSGYKTSGGLHGVGASAVNALSLRFDVTVKRQGKVHEISFQRGVPGVFAGDGPDATFTPQPGLRVTRRMKRNETSGTSTRYWYDARYFESGARLDADVVRAKLRNTAFLVPGVQYTLADFTGAEPREETFQFPHGLADMVEFLTPSSDKPVSGMLMIAGEGTYKENAADANGVMQSNVERRAEIEIAFRWSTGYERTVECFTNTIRNVHGGTHRKGFERALVRALSDAVRNARGLLKPKEDAPVLDDYLEGLTAVIHVRVPEPQFTSQTKDELSTAGITRVLQGLVEQHLKQWIDDRRSKAEARTVLQKVVDAARVRLTQKQQKDAARRKTALEGASMPPKLVDCRSTGIGRSELYIVEGDSALGTARMARSSEYQALLPIRGKILNVQKASLQQVLDNAECSAIVQVLGAGSGRTFDLSTMRYGRVMIMADADVDGSHIRTLLITLFAKYMRPVIESGRLYAAMPPLHKVSTKGRNAETIYTYTQQEMEATVGRFEKAGRSVSKPVPRFKGLGEMDADELWDTTMNPASRTVRRITLDDAERAEATLELLMGERVEPRKNWLIEAAGRIDQDTIDA
>NC_021191.1|WP_157408927.1|7168908_7171971_-|coagulation-factor-5/8-type-domain-protein
MDHPAGPPLPPSSCPAATPAERKFPAIRRSSVSLVVLTLIAVYLGVVQGAAQAADSLLSQGRPATASSQEGNDVPATNAVDGNAGTRWSSQFADPQWLQIDLGAVSSISQVVLQWENAYGKAYKIQTSTDGSAWTDIYSTSNGAGGTETLTVSGSGRYVRMYGTQRAGGYGYSLWEFKVYGSPGSNPGNPGNPGDPSWTTVWSDDFTGAANTSPSSANWLLRTGTQYPGGAANWGTGEVETATAATTNVFLDGAGKLNIKAIRDGTGNWTSGRLETQRSDFEPRAGEQTRFAAVLKQPDVSNGNGYWPGFRATGAAYRGNYNNWPGVGETDIMTDVNGRSQLSQTLHCGTAPDGPCAEYNGRSSGLASCSGCQTGFHEYAQVIDRTKTDEEIRFYLDGRQTWIVRESQVGVTAWTAAIHHGFFLRLDLGIGGSLPNANAGFTTPTPDTTSGGVLSVDSVTVSRSAGSTPAAMTDPATPAGPSVVRVTGTQGNWQLNVNGSAYEVKGLTYGPPQAAADGYLRDLKNMGVNTIRIWGVDDANTPTLLDRAAQQGIKVIIGHWLNQGADYVNDTAYKNSVKSEIVSRVNALKNRQGVLMWDVGNEVILTMQDHGLSAAEVEARRIGYAKFVNELAQAIHAADPNHPVTSTDAYTGAWPYYKQYAPDLDLLAVNSYGAIGNVKQDWINGGYSKPYIVTEGGPAGEWEVPVDVNGLPTEPSDLQKRAGYTASWNAIKAHPGVALGATEFHYGLENDFGGIWLNTFTGGWRRLGYHALRQAYTGQASPNTPPEITSMSVSGQTAVPAGGTFTVAAAANDPNGDLIRWNLMFSDKHITGNTGLTNVVFTDNGNGTFTVRAPEQLGVWKVYVYAYDGQGNVGIEQRSFKVVPPPIPGTDLSRGKSVSTSSYQPTGTNGAQLPGYAVDGDYGTRWASEWVDTAWLQVDLGSVQSFNHVRLAWEAAYAKGYNVQVSNDGATWNTIYSTATGNGGFDDLAVSGSGRYVRVNGTVRGSAYGYSLWEFGVYRS
>NC_021191.1|WP_015624332.1|7173007_7173616_+|DUF305-domain-containing-protein
MNRHSTQPRLNRRATFAAGWAVLTAVAAAACSGGDAATTSAQQPAAAVASGGGAQVFGGTDIAWIEITIAMDEQLLPLLALVPTHSSNAQLKALIGEVTATHQQELGTLRALHDEAKLPAENPHEGMPMPGMVTPEQVTAAAAQNGPAFDKLVVTQLKAHLDQGVNLAGSEGKAGVEPRTKKLAENVLSSRRTYLSRLAEFD
>NC_021191.1|WP_015624333.1|7173719_7175114_-|DUF1996-domain-containing-protein
MRTKLRRLVVPLGVAALAGTALAVGMPQAQAADSLLSQGKPAIASSVENGESPAAAAVDGRTETRWGSQWADPQWLRVDLGTAASINRVVLQWETAYAKSYKIQTSGDGNAWTDIYSTTSGAGGTQTLTVAGSGRYVRMYGTQRGTTYGYSLFEFKVYGTSASTPPTDGDGYVYANPPVTGVTPSTATPPATNPPTTHHEFQANCSVSRSNLPDDPIVFPNMPGASHSHTFMGNTTTNAATTLTSLQAGQTSCITPGDKTGYWMPTLLNGDTPVQPVGRQVIYYKSGVLDYRSVRPSPPGLRYVVGSPLATLDEFRNSPGAVEGFECGDSVRNWDIPANCVSGSQLNVRFQAPSCWDGIHLDTPDHKSHMAYPVVGVCPADHPVAVPMIEFKMAWPVSGNLSNVHFASGRGYSFHYDFYNAWDAPTLAALVSHCINGGLQCDPRGFDQYKPDRGAALNENYELP
>NC_021191.1|WP_041832695.1|7175808_7176315_-|hemerythrin-domain-containing-protein
MAEGENTRSVTSPAAATTARLVAWSQELRTVHARLRQALSVTGQALDAGTPAEPATRDLLLFCHGFCAALTAHHKGEDNHLFPAIAEQYPQLLDTLRRLRQDHSMIAHLLGGLQAAVARSDPPEALRRHLEGIAAIMESHFRFEERQLTEVLENLKLTTDPQTVFGPL
>NC_021191.1|WP_015624335.1|7176746_7177898_+|LacI-family-transcriptional-regulator
MTTTSTLVGKGHAETGKKPASASRKTGGTPASASRKERNERGGGLPTLEDVAKVAGVSRATASRVINGVRNVDPQLHEMVWNAVGQTGYVPNRLARSLVTRRTGTVALVVSDNEAHDDDPFMGRFFADPYFGRVVGGLMSVLRTAGIQLALQIVGTEEQRTRLVGDLRHGQADGAVVLSLPGHDPLPGMLTEVGVPAVMIGRPADPVPINYVDLANDSGAAMAADHLVSIGCRVVGMISGPPGVPASNDRVNGFRSAMARHGHAWVPVVAGNFTQDSGEAAVRTLIAQNPGLDGLFVANDLMALGALMALREAARDVPGDVAVVGFDDSSAATSASPPLTTIRHPLEDMAAEAARLLLARIEDPEMRVSSVIYEPALIRRRSA
>NC_021191.1|WP_041832696.1|7177997_7178546_+|LytR-C-terminal-domain-containing-protein
MSFSRVRSLIVFGVLLVAALVVVIVAVSRDTQNGPLADACKGAVMVNATLPRGTSDVTVKVYNGTGRAGVASALTNDLKNRGFATQKPGESKSHIDDVAIVRYGPKALSSAWLLRAFFLNQTKQEYDPKRTSATVDVIVGRGYQQLATPTEVNQSLAALGDPVLPPGSCAAPKKEVAAQAGS
>NC_021191.1|WP_015624337.1|7178611_7179712_-|ionic-transporter-integral-membrane-protein
MAAKISSYLSHWTAYVPVVAVAALILTWGRDLPPPVVVLSALLLAGAVLAAVHHAEVVAHRVGEPFGSLVLAVAVTIIEVALIVTLMISGGEKSQSLARDTVFAAVMITCNGIVGLSLLVGALRRRFAVFNPEGTGGALAAVATIAALSLVLPSFTTSRPGPQFSPAQLGFAAVASLALYLLFVMVQTRRHRDYFLPITTAGKVIDTEEHVDPPPARTALVSVGLLLVALVAVVGLAKGVSPAVESGVASAGLPQSVVGVVIALLVLLPETIAAVRAAARDRIQTSLNLALGSAMASIGLTIPVIAVAMIWLPGPLLLGLGGTQMVLLALTVVVGTLTVVPGRANVLQAGIHLSLLAVFFFLAASP
>NC_021191.1|WP_015624338.1|7179780_7180785_+|glutathione-transferase
MSYVSTEGEFTRDQRYIATRITADGRDGYPVEPGRYRLVVSRACPWANRTIIVRRLLGLEDVLSMGVAGPTHDERSWTFDLDPDGRDPVLGIERLQEAFLKRYPGYDKGITVPAVVDVPTGQVVTNDFAQITIDFSLEWKQFHRPGAPELYPEALREQIDKINKYVFTDVNNGVYRAGFAGSQAAYEKAYHRLFDRLDQLSGILEHQRYLVGDTITEADVRLFTTLVRFDPVYHGHFKCNRSKLTEMPVLWAYARDLFQTPGFGDTIDFVHIKQHYYEVHRDINPTGIVPAGPDLSNWLTEHGRDKLGGRPFGDGTPPPPPRPDEVVAAGHGAA
>NC_021191.1|WP_015624339.1|7180817_7183610_+|SWIM-zinc-finger-family-protein
MSVERWSPAQVEALAPDAGSLKGARSVAAPLSWQACGLIDDVVWGLCKGSGKNPYQVCVDLSGPAYKCSCPSRKFPCKHALGLLLLWSSNGVAEAPAPEFVTEWRAGRVARAARPARAADPAAAQKRADQRTERVAAGLAELSRWLDDQVQQGLATAERAGHRPYDAMAARLVDAQAPGAASAVRRLGTVAGIGAHWADRLLGDLALLRLLVAGHDRLAELPAELAATVRARIGFPVATEDVLATEPVRDQWQVLGQTDSDDGTITTRRTWLLGAGSGRFALHLSFAAPGQSLAADLVPGTSFDGDLCFYPGAAPLRALIKDRLGPTRPLARPTGALGLSAALDGWAAVVAAEPWRTDAPMLLADVVPSSDGHLTGPDGRSLPLAPGYREPWWLLAFSGGAPATVAGEWTPNGLRPLAAWAGGRFVPAGPPMPDGSAARSPELPPDLLATALVGTGRRPFTASTVAVGDTSVPVGQASLLEAAATALAYRRAGLTPVTGHDPVEPAPRETQAPVPAPAGLRLQRLLSDGGTQAQELLAQWLGAAVEHGGHAPPVTLPALLDAGRRNSIIRPAIGRVAGRRGQWLAALRPDWHWLRDESTGDPGPLDPDGWDTGTPGARLDHLTRLRRSDPAAGLALLRSTWAGESAEDRARFLGALRTGLSTADDEFLDSALDDRRKEVREAALDLLQCLPGASLGRRMAARALAAVRLHDGRLVVDPPDGLTPELRRDGVAAAPARGTGVQAWLLEEIIAGTPLSTWAFAGGPAEVVALARGHDWETPLLHGWAKAAIAQQAPQWAVELVRDDSLREAVRWDLHLLLPPAELARIAADFLRREDHLAHRLLAVHPGEWPDELAVAVVETIAHRARTDKHSWQLAELCRAAALAMPPRWTPHVTRLAAELELSADPSRVRPVSELARTLTFRREMLQEFA
>NC_021191.1|WP_015624340.1|7183619_7183832_-|hypothetical-protein
MAGTAIREPRDPRNSGKVAVAASAAFEAVIAIVNAATDGRVDGALAHHALTVVLVVAVAAILAMTSPGRG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_17

7260342-7260457

Orphan

Consensus_repeat	Method
CCGGGACACCGGTTTCCGGGACACCG	CRISPRCasFinder

2 spacers

csa3

The CRISPR arrays of NC_021191_17

>merge|NC_021191|17|7260342-7260457|CRISPRCasFinder
CCCGGACCGGGGTCTCCGGAAAACCGGTCTCCAGGACACCGACCGCCGGGACACCGGTTTCCGGGACACCGACCGCCGGGACACCGGTTTCCGGGACACCGGTTTCCGGGACACCG

>NC_021191|17|16|7260342-7260457|CRISPRCasFinder
CCCGGACCGGGGTCTCCGGAAAACCG	GTCTCCAGGACACCGACCG
CCGGGACACCGGTTTCCGGGACACCG	ACCGCCGGGACACCGGTTT
CCGGGACACCGGTTTCCGGGACACCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015624409.1\|7256671_7257622_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_021191.1\|WP_020514863.1\|7273022_7273454_+\|SsgA-family-sporulation/cell-division-regulator	unknown	unknown	gnl\|CDD\|377399
NC_021191.1\|WP_015624416.1\|7263615_7264809_+\|nickel-pincer-cofactor-biosynthesis-protein-LarC	unknown	unknown	gnl\|CDD\|376691
NC_021191.1\|WP_063643078.1\|7250646_7251933_-\|mannitol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223324
NC_021191.1\|WP_041832711.1\|7258447_7259458_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_021191.1\|WP_015624421.1\|7270427_7270850_-\|glyoxalase/bleomycin-resistance-protein/dioxygenase	unknown	unknown	gnl\|CDD\|319924
NC_021191.1\|WP_015624403.1\|7249544_7250510_+\|TIGR03086-family-protein	unknown	unknown	gnl\|CDD\|274424
NC_021191.1\|WP_015624420.1\|7269432_7270353_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187572
NC_021191.1\|WP_041832712.1\|7260494_7261484_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_021191.1\|WP_051167845.1\|7272321_7272705_-\|TIGR02611-family-protein	unknown	unknown	gnl\|CDD\|131660
NC_021191.1\|WP_051167620.1\|7270859_7271267_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_021191.1\|WP_157408586.1\|7254855_7255815_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NC_021191.1\|WP_041832710.1\|7253621_7254926_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270450
NC_021191.1\|WP_015624418.1\|7266572_7267925_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_021191.1\|WP_015624402.1\|7249224_7249548_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_021191.1\|WP_015624410.1\|7257623_7258451_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|366542
NC_021191.1\|WP_015624408.1\|7255811_7256675_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_021191.1\|WP_015624406.1\|7252082_7253468_-\|glucuronate-isomerase	unknown	unknown	gnl\|CDD\|235087
NC_021191.1\|WP_015624419.1\|7268764_7269325_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NC_021191.1\|WP_051167619.1\|7262758_7263457_+\|nickel-pincer-cofactor-biosynthesis-protein-LarB	unknown	unknown	gnl\|CDD\|224605

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015624409.1\|7256671_7257622_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	5.95763e-53
NC_021191.1\|WP_020514863.1\|7273022_7273454_+\|SsgA-family-sporulation/cell-division-regulator	gnl\|CDD\|377399	pfam04686, SsgA, Streptomyces sporulation and cell division protein, SsgA. The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division.	6.68599e-40
NC_021191.1\|WP_015624416.1\|7263615_7264809_+\|nickel-pincer-cofactor-biosynthesis-protein-LarC	gnl\|CDD\|376691	pfam01969, DUF111, Protein of unknown function DUF111. This prokaryotic family has no known function.	2.79812e-161
NC_021191.1\|WP_063643078.1\|7250646_7251933_-\|mannitol-dehydrogenase-family-protein	gnl\|CDD\|223324	COG0246, MtlD, Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism].	3.28225e-110
NC_021191.1\|WP_041832711.1\|7258447_7259458_+\|oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.02161e-66
NC_021191.1\|WP_015624421.1\|7270427_7270850_-\|glyoxalase/bleomycin-resistance-protein/dioxygenase	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.71383e-31
NC_021191.1\|WP_015624403.1\|7249544_7250510_+\|TIGR03086-family-protein	gnl\|CDD\|274424	TIGR03086, TIGR03086, TIGR03086 family protein. This family, like pfam07398 and TIGRFAMs family TIGR030834, belongs to the larger set of probable enzymes defined in family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized.	2.03439e-29
NC_021191.1\|WP_015624420.1\|7269432_7270353_+\|SDR-family-oxidoreductase	gnl\|CDD\|187572	cd05262, SDR_a7, atypical (a) SDRs, subgroup 7. This subgroup contains atypical SDRs of unknown function. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.74847e-112
NC_021191.1\|WP_041832712.1\|7260494_7261484_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.40752e-91
NC_021191.1\|WP_051167845.1\|7272321_7272705_-\|TIGR02611-family-protein	gnl\|CDD\|131660	TIGR02611, Putative_membrane_protein, TIGR02611 family protein. Members of this family are Actinobacterial putative proteins of about 150 amino acids in length with three apparent transmembrane helix and an unusual motif with consensus sequence PGPGW. [Hypothetical proteins, Conserved].	3.03297e-17
NC_021191.1\|WP_051167620.1\|7270859_7271267_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	2.06902e-28
NC_021191.1\|WP_157408586.1\|7254855_7255815_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.74348e-59
NC_021191.1\|WP_041832710.1\|7253621_7254926_+\|extracellular-solute-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.34539e-40
NC_021191.1\|WP_015624418.1\|7266572_7267925_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.77025e-54
NC_021191.1\|WP_015624402.1\|7249224_7249548_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.34246e-20
NC_021191.1\|WP_015624410.1\|7257623_7258451_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|366542	pfam01261, AP_endonuc_2, Xylose isomerase-like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.	2.66009e-24
NC_021191.1\|WP_015624408.1\|7255811_7256675_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.16089e-67
NC_021191.1\|WP_015624406.1\|7252082_7253468_-\|glucuronate-isomerase	gnl\|CDD\|235087	PRK02925, PRK02925, glucuronate isomerase; Reviewed.	0
NC_021191.1\|WP_015624419.1\|7268764_7269325_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	2.05458e-15
NC_021191.1\|WP_051167619.1\|7262758_7263457_+\|nickel-pincer-cofactor-biosynthesis-protein-LarB	gnl\|CDD\|224605	COG1691, COG1691, NCAIR mutase (PurE)-related proteins [General function prediction only].	9.2288e-79

>NC_021191.1|WP_041832711.1|7258447_7259458_+|oxidoreductase
MSTPRFAIVGAGVIGTHHGLVTSQLADRLELVAVADVSLDRAERLAAGRGGRPYRTLTEALAAEDIDVVVVCTPTGRHADVAIEALDAGKHVIVEKPAEITVARTDDIIKAQRSAGTLVTVISQHRFDPSTEATLAAIATGELGRLTSGIASIDWWRTQEYYDSGDWRGTWDLDGGGALMNQGVHTVDLLIAALGRPVEVFAYTATLAHDRIEVEDVATGVVRFAGGALGVLHATTAACPGLSARLQVHGDRGSAVIDDDRLVYLGSSAAAAQQVPTAGNNPGQLSDAHRLQYLNFLGALAGTETLRVDLETNRQAVAVITGAYESARTGRPVRLS
>NC_021191.1|WP_015624410.1|7257623_7258451_+|sugar-phosphate-isomerase/epimerase
MWTLSGFVDEISADFTEQCRVAAGLGLRYVELRSAWDVNILDLTPARLAVMRTTLAEHDLRVSSIGSPIGKIFVDEPFAPHLDRMRHAAEVARFFAAPYVRIFSFFLRPGADPAAHRDEVIDRMRALARVAEEADLVLLHENEKAIYGDVPARCRDVVRSVGSPHLRLAWDPANFVQVGVRPYAEGYDILRPHLAYVQIKDALAGDGTVVPAGEGDGDVAETVRALRHDGFDGFFSLEPHLTAGHATGGFSGPEQFRRAWQAFTTILRTEGIEYA
>NC_021191.1|WP_015624409.1|7256671_7257622_+|Gfo/Idh/MocA-family-oxidoreductase
MIRAAIVGCGDVSVVHRRAIEHLDGVELAGTCDVDPSRAPITDHRELLRSVRPDVVHVCTPHDHHVRVATDCLDAGVAVLVEKPVANTVAEAEKLIAAAERNPGVRIGVCLQNRYNATSRAARELLASGALGAVLGASATVCWHRDAAYYQARPWRGERARSGGGVLINQAIHTVDLLEWLIGAVDRVRGQTGRFVHDTIDVEDTATMVLDHVGGARSVLFATVANVVDAPVTIEISTERATLLIRGDLTVRHTDGRVETVAEPVARTGGRAYWGASHELLIADFYRGTGPFWIGPRAGTRSLRLLEQLYDLGKES
>NC_021191.1|WP_015624408.1|7255811_7256675_+|carbohydrate-ABC-transporter-permease
MSASAEAHRLLPRSLLVTVTVVLCAIVLVPTLYIVLASLNSDAGVASGEFWPSSFSPASYRRIWTTADLATGLGNSILVCALVAVASALLGTMTAYVLVRYTFTGRVTVLRGLVGLQSIPGTLMLLPVFVLFSSAGNYLGLTVVGTRWGLFLAYLTFALPFSTWVMVTYLRGLPRELEEAGRVDGASTLRILFRIIVPLSLPAIVVSGIFAFLLGWNDVLFASVLTRPESRTAAVALSTFGATQEGGAIPVYSQVMAAALISAAPVVILYLAFQRYLVGGLTAGGVK
>NC_021191.1|WP_157408586.1|7254855_7255815_+|ABC-transporter-permease-subunit
MRNSTVVSPTRRSPRSPHSTGPSNRGVTERQRPLWLLTPGGLLLTLIIVVPLVLACWISLIDLDQYTLRRWLDAPFVGLDNFTEAFRSGLPHAIWLSVSFAVLATAATVPFGIAAAVATQNAYRGRAVVRAVFLIPYVLPSFVVATVWRTMLQPDGIVNTVLAKVGGGSTLWLSGPASYWTLILVEIWAAWPFIYLMALAGLQSVDGEVHEASAIDGAGWWPKLTRVILPYLRGPVLLACLLATLNHINNFTLPYVLFGAPAPDDVNVMPMIVYVTSFQGLRFGLSAAMAIVSLLLVAIPLFVYLRALRLDVHEDGARR
>NC_021191.1|WP_041832710.1|7253621_7254926_+|extracellular-solute-binding-protein
MRWCAATALVVALTGCGSGDSGGGEGQTLNVLIGANTQYPQEFRAWQKAVSDKFRTQTGATVTFEEFNSANDELTKIQTSVVSGTGPDVYAVGTTLTPTAYSTGAFVKLDAGQWDKVGGKAKFVPATLGISGPDQQNQVGIPFVSRPFVMVCNTELLKAAGISKPASSWDDLRTQAKQLTKGDQYGLAVAYKDNYDPWKFIWGMSAQAGNPLVKDRTATLQDPAVRQAYQTFFGWLTTDKVVDPAAVGWTNAQAIAAFAKGKTGYMALTSTTSAKALDDGAVKGKWSFALLPTVPPGATARPAGGVEAASILSGDNLLVADYSKKKDLAFQFVKMITDQDAQLDYYKATGNLPANAASLQTLSTDAQLAPVAQAAQKSVATPFTGAWADIQLAMTNVVVQSIPDLAKGAVSDAQLDSRLADAQKSAQSALDRAK
>NC_021191.1|WP_015624406.1|7252082_7253468_-|glucuronate-isomerase
MAALTVHPDRLLPAEPGVRAIARELYESVRDRPIISPHGHVDPALLLADRPFADPASLFIQPDHYVTRLLHAGGVSLDELGVGEGPLPEDRARHAWRLLCANWQLLRGTPVRHWFDSELAEIFGITERPDAGNADSLYDRIAGQLPQPSHRPRALLRRFGIEFLATTDDPADDLGTHRALRADPDITTTVAPTFRPDRYLELGRPDWAGSVQECGDYAGYLAWLEDRRRHFIANGAVSADHGHADAGAEPLERHEAERIYRNALSGAVTPAEATAFRRHMTFEMARMSCDDGLVMTLHPGVFRNHHPATLAAHGPDTGHDIPTTVEFTRALQPLLARFGTHPGFHLVLFTVDPDTYSREIAPLAGFYPAVYAGAPWWFLDNPSEIRRFQHAVTETAGFSRLSGFIDDTRAFCSIPARHDMSRRLDAGFLASLVTTHRLDLDEARATLGTLVSEQPRKVFKL
>NC_021191.1|WP_063643078.1|7250646_7251933_-|mannitol-dehydrogenase-family-protein
MPGAASSPGGASFSGGAGSSADPDADWGIAAFTGRSPGLAKQLSVQDCRYTLIERGPDRDVLTVQTAVVAAHPGTDLEALKSYLERPELAIVTLTVTEAAYRRNREGGLDVSDPDVRADRAAVQPGAGTVPVTVPGRLVAGLAARRAAGTGPLAVVSCDNLPGNGAVTRRVVLDMAEAVPGLAHWIAGNVSFVTTMVDRITPRTTPDDVRAVAEQTGWADAVPVVTEPFTEWVLSGDFPAGRPAWEAAGARFVADVHPHEMRKLLLLNGGHSLLAYGGSARGHETIAAAVSDPVCRGWLEQWWDEAVRSVPLPADEVADYRRALLERFANPRIRHTLAQIAADGSQKVPIRVLPVLRAEHAAGRLPAGAVRILAAWIDHLRGIGAPVNDAGAAPYQDRAGSVRDVLGLLAPDLADDRALTDAVEAACR
>NC_021191.1|WP_015624403.1|7249544_7250510_+|TIGR03086-family-protein
MNVEKTALLPISPDEAFALITQPDRLRRWLAVSARIDLRAGGQFRWTLTPMAVAAGTVVAVEPGRRIVLGFDAESSGESPAGTVTITIEPAEGGTLVRLIHDDLPEDQGDGILEGWTHFFERLERAAAAGDAGPDEWAAAPERLDPLTSANATLAVLQQVLYGIGEDDLGRPTPCTAFTVGQLEEHLLGSLTSLTGLAGGTLTPPSAGRLESRIADAGQQAVETWMRRGLDGTVQAGPQELPATLAASILSVEFLVHAWDFASATGQKVTVSDEVSTYVLGLADQIITPELRESAGFDPAIPISETASPLDRLIAFSGRTA
>NC_021191.1|WP_015624402.1|7249224_7249548_+|winged-helix-turn-helix-transcriptional-regulator
MADALSAAAEPTRRRLLQLLATGPRTVNELAEHFTVTRSAISQHLAVLADAGLVTARKDGRQRFYRVVPAGIAQLRAEINRFWSTELELLVHDATGTATQQPEEPPQ
>NC_021191.1|WP_041832712.1|7260494_7261484_-|LacI-family-transcriptional-regulator
MGRRPTIYDVAREAGVAASTVSRAYARPGRVNTDTARKVFEVAERLGYRTGRPPGFHPQGGSSEAIALVIADVTNPFYGEIIKGAYEAARRAGYQLVLSHTNESPEEERRTIERELAHVDGIVIASSRMTDSALRMMAKQRPVVLLNRTLPEASCLVNDNQRGIRRAAEHLGSLGHDRILYLAGPENSWSDGTRWRALREAARHLHLDVRRIGPHEPTVLAGLSAARRVVQTDATAVLAYNDALAIGVMKGLRKLGLTVPEEISVIGFDNILLDELVEPALTTVAAPLYRMGLTGVRNCIAIAQGARLSSTPIVLPVRLVIRQSTAHRR
>NC_021191.1|WP_051167619.1|7262758_7263457_+|nickel-pincer-cofactor-biosynthesis-protein-LarB
MTEAGYESTPDTFADLDLGRAVRRGYPEAVYCEGKTPAQVAAIAAQVGRRPDVVTLFTRADADRAAAVLEQLPDALHDPGARLLAWPPEPPRPTGGLVVVLAAGTSDLPVAREAELTARYLGRATELVADVGVAGLHRVLGRLDLLRRARAVIVAAGMDGALPSVVAGLIAAPVVALPTSVGYGAAFHGLAPLLAMLNACAPGIGVVNIDNGYGAGHLAAQIAAPLTSQGPA
>NC_021191.1|WP_015624416.1|7263615_7264809_+|nickel-pincer-cofactor-biosynthesis-protein-LarC
MTGGRHLWIDASAGIAGDMLLGALLDAGADLGLVQRAVDAVVPGSVRLTTTVVTRAGLRARRAHVDVLTAGPPRRTWRDIRELLDALDAPVRTRALAVFARLADAEAHVHGTPVDDVHFHEVGALDSIADVVGVCAALENLSVTTVSAGEVALGSGTARTAHGELPVPVPAVTHLALGWQVRGGGPGELATPTGMAALRTLATGCETLPSMVVEAVGVGAGSRDTPDHPNVVRVMLGRTTAATETAVLIEANVDDLDPRLWPGVLTELVQAGAADAWLTPIVMKKGRPAHTLSVLSSPGYAAALRDLVFDLTTTLGVRETTVRKYPLARTFVGVDVRGRTIAIKIGHRDGTIVRVMPEFDEVAALACDLGRPEQAILAEAHAAAAAEGLTPGARLPA
>NC_021191.1|WP_015624418.1|7266572_7267925_+|two-component-sensor-histidine-kinase
MGDAQALWQRRLEPLTTVFPYVLLAVLTVSTYLANQQTLLDLGLCTLAAVWIMVLFTLRPAWRERPRVMETFLAGLLLITLVLAIRNPWFGFYTPVCYLYAFRIIRWPTQLYFITGSAVVAGTAQANGLDLTSLGGILAYAAILLVNAVPLGGTAWLGQVTERREREREAALAETSAANERLAAALRENADLQQQLLTQARTAGVLDERHRMAREIHDTLAQGLIGIITQLQAADAADSRTGWQRHHDSATALARESLTEARRSVNALRPQPLDTGRLDDALASVTAQWSQRHNVPAAFVTTGPARPLPPEAETVLLRTTQEALANVARHASATRVGITLSYLPSDITLDIRDDGCGFDPAPQPPTRTTDSPTPTQQPPTRTTDAPTPAQQPPTRTTHAPTPTHQPPTEATGGFGLEAMRQRIEGLSGTLDIESSPGAGTTITARLPLAP
>NC_021191.1|WP_015624419.1|7268764_7269325_-|TetR-family-transcriptional-regulator
MPRSGAEARRRLQQAALDLYRERGFDQTTAADIAARAGVNERTFFRHFPDKREVLFDGEDELRAALAQHVAASGERFPYDILLDAFRKSARILEDNRPYAEPRLALIAATPALRERDLAKAAAMADALAEALRLRGVPAQLAALAAQTGWATFHHAAQRWIDDPAQGLDAHLVQAFDDVRSLSGRP
>NC_021191.1|WP_015624420.1|7269432_7270353_+|SDR-family-oxidoreductase
MHVFVTGGSGLTGPTVVAELIASGHAVTALARSDAAAARLTALGATPHRGSLDDLDSLRRGAEPADGVLHMAFGGDFADPDDMMRRDRAAIEALGKVLEHTGKPFVSTSGTLVMPPGRLSTEHDEPLLDGIAGFRVPGERACLDFAAHGVRASVLRLAPTVHGPGEPAHGFIGNLVATARRTGRAAYIGDGTNRWPAVDRRDAATLFRLALEKATAGSILHGVAEPGVPFRSIAETIARGLGIPAVSLTPAEATEHFGNRFMATIYALDAPVSSILTQQELGWSPRHWTLVEDLTDGDYLRSQPRT
>NC_021191.1|WP_015624421.1|7270427_7270850_-|glyoxalase/bleomycin-resistance-protein/dioxygenase
MLNKVRITHVFVADQDEALDFYVGKLGLEVADDIDLGVMRWLTVRVPGDDPDRVILLEKPGPPAMDAQAAEQVRELIAKGASGFTLGFTTDDARKTYDELKANGVEMTDGPTEQPYGIDFGARDPFGNHFRVSQPAGPIG
>NC_021191.1|WP_051167620.1|7270859_7271267_-|helix-turn-helix-transcriptional-regulator
MLRARDAMDRAYTEPLDVASLARVAHVSPRHFIRTFRATFGETPHRYLQRRRVERAMFLLRESSQSVTQVCMSVGFSSLGTFSRTFHAILGESPSAYRKRAVPSYVPSCFGMAYMRPVSSGDMSLLDKHGGDAGR
>NC_021191.1|WP_051167845.1|7272321_7272705_-|TIGR02611-family-protein
MPHSDLLDRVRANRTGRLALKIGIGILGTLVVATGIVLIPFPGPGWAIVIVGLAIWAVEFDWAKRLLHFTRRHVQAWTHWVLEQSLPVRALIGLAGFIFISAVVWLSVKLSLGIDLAVLIGNFLTGT
>NC_021191.1|WP_020514863.1|7273022_7273454_+|SsgA-family-sporulation/cell-division-regulator
MSTIRPTTVEVETSLRLVAPDATALPVRASLRYDPADPYAVHVLFHAESAGGEAVSWSFARELLVTGLDEPAGIGDVRVWPWATPRGDFVALALSSPDGNALFEVPRSVLVRFLRRTYVVVPRGRESEHLDVDAAVNRLLAGR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_18

7268013-7268414

Orphan

Consensus_repeat	Method
GCTCTCNCNCACCGCNGCCGCCCGAGGCAGCGCTCTCCC	CRT

6 spacers

The CRISPR arrays of NC_021191_18

>merge|NC_021191|18|7268013-7268414|CRT
GCTCTCCCTAACCGCGCCCGTCCAAAACCGCGCTCTCCCCCACCGCCGCCGCCCGAGGCAGCGCTCTCCCGCACCGCCGCCGCCCGAGGCAGCGCTCTCCCGCAACGCGGCCAGCCAACGCTGGCTCTCGCACACCGCAGCCGCCCGAGGCAGCGCTCTCCCGCAACGCGGCCAGCCAACGCTGGCTCTCGCACACCGCAGCCGCCCGAGGCAGCGCTCTCCCACACCGTCCCCTAAAGCAGCGCTCTCCCGCACCGCAGCCGCCCGAGGCAGCACTCTCCCGCAACGCGGCCAGCCCAGGCACGCTCTCGCACACCGCGGCCGCCCGAGGCAGGGCTCTCCCACACCGTCCCCAGAAGCAGCGCTCTCCCGCACCGCCGTCGCCCGAGGCATGCTTTCCCC

>NC_021191|18|1|7268013-7268414|CRT
GCTCTCCCTAACCGCGCCCGTCCAAAACCGCGCTCTCCC	CCACCGCCGCCGCCCGAGGCAGC
GCTCTCCCGCACCGCCGCCGCCCGAGGCAGCGCTCTCCC	GCAACGCGGCCAGCCAACGCTG
GCTCTCGCACACCGCAGCCGCCCGAGGCAGCGCTCTCCC	GCAACGCGGCCAGCCAACGCTG
GCTCTCGCACACCGCAGCCGCCCGAGGCAGCGCTCTCCC	ACACCGTCCCCTAAAGCAGC
GCTCTCCCGCACCGCAGCCGCCCGAGGCAGCACTCTCCC	GCAACGCGGCCAGCCCAGGCAC
GCTCTCGCACACCGCGGCCGCCCGAGGCAGGGCTCTCCC	ACACCGTCCCCAGAAGCAGC
GCTCTCCCGCACCGCCGTCGCCCGAGGCATGCTTTCCCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_015624409.1\|7256671_7257622_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_021191.1\|WP_020514863.1\|7273022_7273454_+\|SsgA-family-sporulation/cell-division-regulator	unknown	unknown	gnl\|CDD\|377399
NC_021191.1\|WP_015624418.1\|7266572_7267925_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_021191.1\|WP_041832711.1\|7258447_7259458_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_021191.1\|WP_015624421.1\|7270427_7270850_-\|glyoxalase/bleomycin-resistance-protein/dioxygenase	unknown	unknown	gnl\|CDD\|319924
NC_021191.1\|WP_084504318.1\|7273640_7274573_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_021191.1\|WP_015624428.1\|7275422_7276283_-\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015624420.1\|7269432_7270353_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187572
NC_021191.1\|WP_041832712.1\|7260494_7261484_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_021191.1\|WP_051167845.1\|7272321_7272705_-\|TIGR02611-family-protein	unknown	unknown	gnl\|CDD\|131660
NC_021191.1\|WP_051167620.1\|7270859_7271267_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_021191.1\|WP_157408586.1\|7254855_7255815_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NC_021191.1\|WP_041832710.1\|7253621_7254926_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270450
NC_021191.1\|WP_015624419.1\|7268764_7269325_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NC_021191.1\|WP_015624427.1\|7275188_7275374_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015624410.1\|7257623_7258451_+\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|366542
NC_021191.1\|WP_015624408.1\|7255811_7256675_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NC_021191.1\|WP_015624426.1\|7274639_7275095_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NC_021191.1\|WP_015624416.1\|7263615_7264809_+\|nickel-pincer-cofactor-biosynthesis-protein-LarC	unknown	unknown	gnl\|CDD\|376691
NC_021191.1\|WP_051167619.1\|7262758_7263457_+\|nickel-pincer-cofactor-biosynthesis-protein-LarB	unknown	unknown	gnl\|CDD\|224605

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_015624409.1\|7256671_7257622_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	5.95763e-53
NC_021191.1\|WP_020514863.1\|7273022_7273454_+\|SsgA-family-sporulation/cell-division-regulator	gnl\|CDD\|377399	pfam04686, SsgA, Streptomyces sporulation and cell division protein, SsgA. The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division.	6.68599e-40
NC_021191.1\|WP_015624418.1\|7266572_7267925_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.77025e-54
NC_021191.1\|WP_041832711.1\|7258447_7259458_+\|oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.02161e-66
NC_021191.1\|WP_015624421.1\|7270427_7270850_-\|glyoxalase/bleomycin-resistance-protein/dioxygenase	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.71383e-31
NC_021191.1\|WP_084504318.1\|7273640_7274573_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	3.78532e-20
NC_021191.1\|WP_015624420.1\|7269432_7270353_+\|SDR-family-oxidoreductase	gnl\|CDD\|187572	cd05262, SDR_a7, atypical (a) SDRs, subgroup 7. This subgroup contains atypical SDRs of unknown function. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.74847e-112
NC_021191.1\|WP_041832712.1\|7260494_7261484_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.40752e-91
NC_021191.1\|WP_051167845.1\|7272321_7272705_-\|TIGR02611-family-protein	gnl\|CDD\|131660	TIGR02611, Putative_membrane_protein, TIGR02611 family protein. Members of this family are Actinobacterial putative proteins of about 150 amino acids in length with three apparent transmembrane helix and an unusual motif with consensus sequence PGPGW. [Hypothetical proteins, Conserved].	3.03297e-17
NC_021191.1\|WP_051167620.1\|7270859_7271267_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	2.06902e-28
NC_021191.1\|WP_157408586.1\|7254855_7255815_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.74348e-59
NC_021191.1\|WP_041832710.1\|7253621_7254926_+\|extracellular-solute-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.34539e-40
NC_021191.1\|WP_015624419.1\|7268764_7269325_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	2.05458e-15
NC_021191.1\|WP_015624410.1\|7257623_7258451_+\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|366542	pfam01261, AP_endonuc_2, Xylose isomerase-like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.	2.66009e-24
NC_021191.1\|WP_015624408.1\|7255811_7256675_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.16089e-67
NC_021191.1\|WP_015624426.1\|7274639_7275095_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	1.09144e-35
NC_021191.1\|WP_015624416.1\|7263615_7264809_+\|nickel-pincer-cofactor-biosynthesis-protein-LarC	gnl\|CDD\|376691	pfam01969, DUF111, Protein of unknown function DUF111. This prokaryotic family has no known function.	2.79812e-161
NC_021191.1\|WP_051167619.1\|7262758_7263457_+\|nickel-pincer-cofactor-biosynthesis-protein-LarB	gnl\|CDD\|224605	COG1691, COG1691, NCAIR mutase (PurE)-related proteins [General function prediction only].	9.2288e-79

>NC_021191.1|WP_015624418.1|7266572_7267925_+|two-component-sensor-histidine-kinase
MGDAQALWQRRLEPLTTVFPYVLLAVLTVSTYLANQQTLLDLGLCTLAAVWIMVLFTLRPAWRERPRVMETFLAGLLLITLVLAIRNPWFGFYTPVCYLYAFRIIRWPTQLYFITGSAVVAGTAQANGLDLTSLGGILAYAAILLVNAVPLGGTAWLGQVTERREREREAALAETSAANERLAAALRENADLQQQLLTQARTAGVLDERHRMAREIHDTLAQGLIGIITQLQAADAADSRTGWQRHHDSATALARESLTEARRSVNALRPQPLDTGRLDDALASVTAQWSQRHNVPAAFVTTGPARPLPPEAETVLLRTTQEALANVARHASATRVGITLSYLPSDITLDIRDDGCGFDPAPQPPTRTTDSPTPTQQPPTRTTDAPTPAQQPPTRTTHAPTPTHQPPTEATGGFGLEAMRQRIEGLSGTLDIESSPGAGTTITARLPLAP
>NC_021191.1|WP_015624416.1|7263615_7264809_+|nickel-pincer-cofactor-biosynthesis-protein-LarC
MTGGRHLWIDASAGIAGDMLLGALLDAGADLGLVQRAVDAVVPGSVRLTTTVVTRAGLRARRAHVDVLTAGPPRRTWRDIRELLDALDAPVRTRALAVFARLADAEAHVHGTPVDDVHFHEVGALDSIADVVGVCAALENLSVTTVSAGEVALGSGTARTAHGELPVPVPAVTHLALGWQVRGGGPGELATPTGMAALRTLATGCETLPSMVVEAVGVGAGSRDTPDHPNVVRVMLGRTTAATETAVLIEANVDDLDPRLWPGVLTELVQAGAADAWLTPIVMKKGRPAHTLSVLSSPGYAAALRDLVFDLTTTLGVRETTVRKYPLARTFVGVDVRGRTIAIKIGHRDGTIVRVMPEFDEVAALACDLGRPEQAILAEAHAAAAAEGLTPGARLPA
>NC_021191.1|WP_051167619.1|7262758_7263457_+|nickel-pincer-cofactor-biosynthesis-protein-LarB
MTEAGYESTPDTFADLDLGRAVRRGYPEAVYCEGKTPAQVAAIAAQVGRRPDVVTLFTRADADRAAAVLEQLPDALHDPGARLLAWPPEPPRPTGGLVVVLAAGTSDLPVAREAELTARYLGRATELVADVGVAGLHRVLGRLDLLRRARAVIVAAGMDGALPSVVAGLIAAPVVALPTSVGYGAAFHGLAPLLAMLNACAPGIGVVNIDNGYGAGHLAAQIAAPLTSQGPA
>NC_021191.1|WP_041832712.1|7260494_7261484_-|LacI-family-transcriptional-regulator
MGRRPTIYDVAREAGVAASTVSRAYARPGRVNTDTARKVFEVAERLGYRTGRPPGFHPQGGSSEAIALVIADVTNPFYGEIIKGAYEAARRAGYQLVLSHTNESPEEERRTIERELAHVDGIVIASSRMTDSALRMMAKQRPVVLLNRTLPEASCLVNDNQRGIRRAAEHLGSLGHDRILYLAGPENSWSDGTRWRALREAARHLHLDVRRIGPHEPTVLAGLSAARRVVQTDATAVLAYNDALAIGVMKGLRKLGLTVPEEISVIGFDNILLDELVEPALTTVAAPLYRMGLTGVRNCIAIAQGARLSSTPIVLPVRLVIRQSTAHRR
>NC_021191.1|WP_041832711.1|7258447_7259458_+|oxidoreductase
MSTPRFAIVGAGVIGTHHGLVTSQLADRLELVAVADVSLDRAERLAAGRGGRPYRTLTEALAAEDIDVVVVCTPTGRHADVAIEALDAGKHVIVEKPAEITVARTDDIIKAQRSAGTLVTVISQHRFDPSTEATLAAIATGELGRLTSGIASIDWWRTQEYYDSGDWRGTWDLDGGGALMNQGVHTVDLLIAALGRPVEVFAYTATLAHDRIEVEDVATGVVRFAGGALGVLHATTAACPGLSARLQVHGDRGSAVIDDDRLVYLGSSAAAAQQVPTAGNNPGQLSDAHRLQYLNFLGALAGTETLRVDLETNRQAVAVITGAYESARTGRPVRLS
>NC_021191.1|WP_015624410.1|7257623_7258451_+|sugar-phosphate-isomerase/epimerase
MWTLSGFVDEISADFTEQCRVAAGLGLRYVELRSAWDVNILDLTPARLAVMRTTLAEHDLRVSSIGSPIGKIFVDEPFAPHLDRMRHAAEVARFFAAPYVRIFSFFLRPGADPAAHRDEVIDRMRALARVAEEADLVLLHENEKAIYGDVPARCRDVVRSVGSPHLRLAWDPANFVQVGVRPYAEGYDILRPHLAYVQIKDALAGDGTVVPAGEGDGDVAETVRALRHDGFDGFFSLEPHLTAGHATGGFSGPEQFRRAWQAFTTILRTEGIEYA
>NC_021191.1|WP_015624409.1|7256671_7257622_+|Gfo/Idh/MocA-family-oxidoreductase
MIRAAIVGCGDVSVVHRRAIEHLDGVELAGTCDVDPSRAPITDHRELLRSVRPDVVHVCTPHDHHVRVATDCLDAGVAVLVEKPVANTVAEAEKLIAAAERNPGVRIGVCLQNRYNATSRAARELLASGALGAVLGASATVCWHRDAAYYQARPWRGERARSGGGVLINQAIHTVDLLEWLIGAVDRVRGQTGRFVHDTIDVEDTATMVLDHVGGARSVLFATVANVVDAPVTIEISTERATLLIRGDLTVRHTDGRVETVAEPVARTGGRAYWGASHELLIADFYRGTGPFWIGPRAGTRSLRLLEQLYDLGKES
>NC_021191.1|WP_015624408.1|7255811_7256675_+|carbohydrate-ABC-transporter-permease
MSASAEAHRLLPRSLLVTVTVVLCAIVLVPTLYIVLASLNSDAGVASGEFWPSSFSPASYRRIWTTADLATGLGNSILVCALVAVASALLGTMTAYVLVRYTFTGRVTVLRGLVGLQSIPGTLMLLPVFVLFSSAGNYLGLTVVGTRWGLFLAYLTFALPFSTWVMVTYLRGLPRELEEAGRVDGASTLRILFRIIVPLSLPAIVVSGIFAFLLGWNDVLFASVLTRPESRTAAVALSTFGATQEGGAIPVYSQVMAAALISAAPVVILYLAFQRYLVGGLTAGGVK
>NC_021191.1|WP_157408586.1|7254855_7255815_+|ABC-transporter-permease-subunit
MRNSTVVSPTRRSPRSPHSTGPSNRGVTERQRPLWLLTPGGLLLTLIIVVPLVLACWISLIDLDQYTLRRWLDAPFVGLDNFTEAFRSGLPHAIWLSVSFAVLATAATVPFGIAAAVATQNAYRGRAVVRAVFLIPYVLPSFVVATVWRTMLQPDGIVNTVLAKVGGGSTLWLSGPASYWTLILVEIWAAWPFIYLMALAGLQSVDGEVHEASAIDGAGWWPKLTRVILPYLRGPVLLACLLATLNHINNFTLPYVLFGAPAPDDVNVMPMIVYVTSFQGLRFGLSAAMAIVSLLLVAIPLFVYLRALRLDVHEDGARR
>NC_021191.1|WP_041832710.1|7253621_7254926_+|extracellular-solute-binding-protein
MRWCAATALVVALTGCGSGDSGGGEGQTLNVLIGANTQYPQEFRAWQKAVSDKFRTQTGATVTFEEFNSANDELTKIQTSVVSGTGPDVYAVGTTLTPTAYSTGAFVKLDAGQWDKVGGKAKFVPATLGISGPDQQNQVGIPFVSRPFVMVCNTELLKAAGISKPASSWDDLRTQAKQLTKGDQYGLAVAYKDNYDPWKFIWGMSAQAGNPLVKDRTATLQDPAVRQAYQTFFGWLTTDKVVDPAAVGWTNAQAIAAFAKGKTGYMALTSTTSAKALDDGAVKGKWSFALLPTVPPGATARPAGGVEAASILSGDNLLVADYSKKKDLAFQFVKMITDQDAQLDYYKATGNLPANAASLQTLSTDAQLAPVAQAAQKSVATPFTGAWADIQLAMTNVVVQSIPDLAKGAVSDAQLDSRLADAQKSAQSALDRAK
>NC_021191.1|WP_015624419.1|7268764_7269325_-|TetR-family-transcriptional-regulator
MPRSGAEARRRLQQAALDLYRERGFDQTTAADIAARAGVNERTFFRHFPDKREVLFDGEDELRAALAQHVAASGERFPYDILLDAFRKSARILEDNRPYAEPRLALIAATPALRERDLAKAAAMADALAEALRLRGVPAQLAALAAQTGWATFHHAAQRWIDDPAQGLDAHLVQAFDDVRSLSGRP
>NC_021191.1|WP_015624420.1|7269432_7270353_+|SDR-family-oxidoreductase
MHVFVTGGSGLTGPTVVAELIASGHAVTALARSDAAAARLTALGATPHRGSLDDLDSLRRGAEPADGVLHMAFGGDFADPDDMMRRDRAAIEALGKVLEHTGKPFVSTSGTLVMPPGRLSTEHDEPLLDGIAGFRVPGERACLDFAAHGVRASVLRLAPTVHGPGEPAHGFIGNLVATARRTGRAAYIGDGTNRWPAVDRRDAATLFRLALEKATAGSILHGVAEPGVPFRSIAETIARGLGIPAVSLTPAEATEHFGNRFMATIYALDAPVSSILTQQELGWSPRHWTLVEDLTDGDYLRSQPRT
>NC_021191.1|WP_015624421.1|7270427_7270850_-|glyoxalase/bleomycin-resistance-protein/dioxygenase
MLNKVRITHVFVADQDEALDFYVGKLGLEVADDIDLGVMRWLTVRVPGDDPDRVILLEKPGPPAMDAQAAEQVRELIAKGASGFTLGFTTDDARKTYDELKANGVEMTDGPTEQPYGIDFGARDPFGNHFRVSQPAGPIG
>NC_021191.1|WP_051167620.1|7270859_7271267_-|helix-turn-helix-transcriptional-regulator
MLRARDAMDRAYTEPLDVASLARVAHVSPRHFIRTFRATFGETPHRYLQRRRVERAMFLLRESSQSVTQVCMSVGFSSLGTFSRTFHAILGESPSAYRKRAVPSYVPSCFGMAYMRPVSSGDMSLLDKHGGDAGR
>NC_021191.1|WP_051167845.1|7272321_7272705_-|TIGR02611-family-protein
MPHSDLLDRVRANRTGRLALKIGIGILGTLVVATGIVLIPFPGPGWAIVIVGLAIWAVEFDWAKRLLHFTRRHVQAWTHWVLEQSLPVRALIGLAGFIFISAVVWLSVKLSLGIDLAVLIGNFLTGT
>NC_021191.1|WP_020514863.1|7273022_7273454_+|SsgA-family-sporulation/cell-division-regulator
MSTIRPTTVEVETSLRLVAPDATALPVRASLRYDPADPYAVHVLFHAESAGGEAVSWSFARELLVTGLDEPAGIGDVRVWPWATPRGDFVALALSSPDGNALFEVPRSVLVRFLRRTYVVVPRGRESEHLDVDAAVNRLLAGR
>NC_021191.1|WP_084504318.1|7273640_7274573_+|AraC-family-transcriptional-regulator
MVTSVQRSVRPAPAPRWAGVGTCTLSETDLAAAHPPPRRLPYHLLALTTAGHGTIEIDFERHLCRPGTLVWVRPGQVLRFGAEPGLDATLVTWERTLLSAAEVTGVPVDDLPGPTRWQLAGEDEDAVITEVAQLGVDCVRHPAPAGDVVAGLLRHQLAVLLLRVALLGGGDHRMTSSSETRTFARFRRDLEDGHGESRRVEDYAARIGCSVRTLTRASLALTGRTAKQVVDDRVALEARRLLACTDLSVAEIGRQLGFGEPTNFGRFFHREVGMSPGAFRVAAGSDATAAGQATGPLIPAQRLSPPHHSG
>NC_021191.1|WP_015624426.1|7274639_7275095_+|Rrf2-family-transcriptional-regulator
MQISARGDYAVRAALSLANAYPALMSAQAIAQDQNMPRKFLEAVLADLRRAGVVRAQRGAEGGYTLSQPPRDITIGQILRAVDGPLAGVRGLRPEETQYTGAAENLPNLWVAVRSAVREVVDEVNLAELISGRMPAHVRKLTTRPDAWQPR
>NC_021191.1|WP_015624427.1|7275188_7275374_+|hypothetical-protein
MGIQYRSRKKFGPLILNFTQHGFSSWTFKIGRWSWNSNTRAHRVDLPGPLSWKQDKSSSRS
>NC_021191.1|WP_015624428.1|7275422_7276283_-|hypothetical-protein
MSADSVAAVKREILVRHLETWAPGALRRGRRATYVHGYADADPTLTTAALEVFADESYLARGRELTVIALGEPPEVKGLSVLTVAGDPEATAGVALKAAGASRVPLLGVWNAAPGPGALAALATGKPAEIVAVLPAGTAAPELRATLHEAGFPLVAEVELAVSDEPGEILVYGTTLGKHLEAFKDLLWAVDEYAGVRYRDPGDPERHLIDISLSPHPGPLRRELLARLVEVGSATVTELRTYALTDTVYRASDATRVLHALLDAGAVTRRPADGRLGGDVVISPGA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_19

7625213-7625564

Orphan

Consensus_repeat	Method
TGACCAACTAGTTAGTCACTTCAC	CRT

6 spacers

The CRISPR arrays of NC_021191_19

>merge|NC_021191|19|7625213-7625564|CRT
CGACCAACTAGTTAGTCACTTCAGACGCCCACCAACCGGCTCCCCCGAGTGACCAACTAGTTAGTCACTTCCCCGAGACAAACCAGCCAGCCAGCCGCGCCAGTAACCAACTAGTTAGTCACCCCACGAGACCAGCCCGGCCGCCCGCACTGGTGACCAACTAGTTAGTCACTTCACAAGACGAACCGGCCGGCCACGCTACTGACCAACCAGCCGGCCACACTACTGACCAACCAGTTAGTCACCCCACGAGACCAGCCGGCCGCCCGCACTAGTGACCAACTAGTTAGTCACTTCTCGAGGCGAACCAGCCGGGCGGCAGCGCTGGTGACCAACCAGTTAGTCACTTCAC

>NC_021191|19|2|7625213-7625564|CRT
CGACCAACTAGTTAGTCACTTCAG	ACGCCCACCAACCGGCTCCCCCGAG
TGACCAACTAGTTAGTCACTTCCC	CGAGACAAACCAGCCAGCCAGCCGCGCCAG
TAACCAACTAGTTAGTCACCCCAC	GAGACCAGCCCGGCCGCCCGCACTGG
TGACCAACTAGTTAGTCACTTCAC	AAGACGAACCGGCCGGCCACGCTACTGACCAACCAGCCGGCCACACTAC
TGACCAACCAGTTAGTCACCCCAC	GAGACCAGCCGGCCGCCCGCACTAG
TGACCAACTAGTTAGTCACTTCTC	GAGGCGAACCAGCCGGGCGGCAGCGCTGG
TGACCAACCAGTTAGTCACTTCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_051167633.1\|7621394_7622294_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_021191.1\|WP_051167851.1\|7629594_7630914_+\|ribonuclease-D	unknown	unknown	gnl\|CDD\|223426
NC_021191.1\|WP_015624728.1\|7619876_7620581_+\|chlorite-dismutase-family-protein	unknown	unknown	gnl\|CDD\|377705
NC_021191.1\|WP_015624740.1\|7628447_7629425_-\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|273938
NC_021191.1\|WP_041832767.1\|7625661_7626144_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NC_021191.1\|WP_041832766.1\|7624404_7625202_+\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|376313
NC_021191.1\|WP_157408611.1\|7634425_7635478_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370676
NC_021191.1\|WP_015624734.1\|7623868_7624075_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NC_021191.1\|WP_015624732.1\|7622818_7623094_+\|glycoside-hydrolase-family-13	unknown	unknown	gnl\|CDD\|199892
NC_021191.1\|WP_015624735.1\|7624119_7624368_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015624743.1\|7632165_7634238_+\|3-hydroxyacyl-CoA-dehydrogenase-nad-binding-protein	unknown	unknown	gnl\|CDD\|236864
NC_021191.1\|WP_015624738.1\|7627224_7627782_+\|DUF3000-domain-containing-protein	unknown	unknown	gnl\|CDD\|378665
NC_021191.1\|WP_015624742.1\|7630972_7632169_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NC_021191.1\|WP_015624731.1\|7622312_7622747_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|225064
NC_021191.1\|WP_041834287.1\|7626109_7627147_-\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|234644
NC_021191.1\|WP_084504604.1\|7637024_7638224_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_021191.1\|WP_015624730.1\|7620593_7621337_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235816
NC_021191.1\|WP_041834285.1\|7618482_7619880_+\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|237009
NC_021191.1\|WP_015624739.1\|7627753_7628467_-\|YdcF-family-protein	unknown	unknown	gnl\|CDD\|99750
NC_021191.1\|WP_015624733.1\|7623167_7623773_+\|NAD(P)H:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|179647

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_051167633.1\|7621394_7622294_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	4.02522e-27
NC_021191.1\|WP_051167851.1\|7629594_7630914_+\|ribonuclease-D	gnl\|CDD\|223426	COG0349, Rnd, Ribonuclease D [Translation, ribosomal structure and biogenesis].	7.78501e-81
NC_021191.1\|WP_015624728.1\|7619876_7620581_+\|chlorite-dismutase-family-protein	gnl\|CDD\|377705	pfam06778, Chlor_dismutase, Chlorite dismutase. This family contains chlorite dismutase enzymes of bacterial and archaeal origin. This enzyme catalyzes the disproportionation of chlorite into chloride and oxygen. Note that many family members are hypothetical proteins.	7.40152e-101
NC_021191.1\|WP_015624740.1\|7628447_7629425_-\|trypsin-like-serine-protease	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	8.11924e-31
NC_021191.1\|WP_041832767.1\|7625661_7626144_+\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	2.36421e-60
NC_021191.1\|WP_041832766.1\|7624404_7625202_+\|thymidylate-synthase	gnl\|CDD\|376313	pfam00303, Thymidylat_synt, Thymidylate synthase. This is a family of proteins that are flavin-dependent thymidylate synthases.	0
NC_021191.1\|WP_157408611.1\|7634425_7635478_+\|hypothetical-protein	gnl\|CDD\|370676	pfam09770, PAT1, Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.	7.39238e-07
NC_021191.1\|WP_015624734.1\|7623868_7624075_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	9.34193e-17
NC_021191.1\|WP_015624732.1\|7622818_7623094_+\|glycoside-hydrolase-family-13	gnl\|CDD\|199892	cd07184, E_set_Isoamylase_like_N, N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins. E or "early" set domains are associated with the catalytic domain of isoamylase-like proteins at the N-terminal end. Isoamylase is one of the starch-debranching enzymes that catalyze the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen. Isoamylase contains a bound calcium ion, but this is not in the same position as the conserved calcium ion that has been reported in other alpha-amylase family enzymes. The N-terminal domain of isoamylase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and the beta subunit of AMP-activated protein kinase.	1.85793e-24
NC_021191.1\|WP_015624743.1\|7632165_7634238_+\|3-hydroxyacyl-CoA-dehydrogenase-nad-binding-protein	gnl\|CDD\|236864	PRK11154, fadJ, fatty acid oxidation complex subunit alpha FadJ.	2.14135e-116
NC_021191.1\|WP_015624738.1\|7627224_7627782_+\|DUF3000-domain-containing-protein	gnl\|CDD\|378665	pfam11452, DUF3000, Protein of unknown function (DUF3000). This is a bacterial family of uncharacterized proteins.	4.61483e-86
NC_021191.1\|WP_015624742.1\|7630972_7632169_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	2.2349e-149
NC_021191.1\|WP_015624731.1\|7622312_7622747_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	7.37069e-54
NC_021191.1\|WP_041834287.1\|7626109_7627147_-\|uroporphyrinogen-decarboxylase	gnl\|CDD\|234644	PRK00115, hemE, uroporphyrinogen decarboxylase; Validated.	0
NC_021191.1\|WP_084504604.1\|7637024_7638224_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.69468e-48
NC_021191.1\|WP_015624730.1\|7620593_7621337_-\|SDR-family-oxidoreductase	gnl\|CDD\|235816	PRK06500, PRK06500, SDR family oxidoreductase.	5.41476e-90
NC_021191.1\|WP_041834285.1\|7618482_7619880_+\|NAD(P)-binding-protein	gnl\|CDD\|237009	PRK11883, PRK11883, protoporphyrinogen oxidase; Reviewed.	5.81721e-103
NC_021191.1\|WP_015624739.1\|7627753_7628467_-\|YdcF-family-protein	gnl\|CDD\|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	1.76761e-11
NC_021191.1\|WP_015624733.1\|7623167_7623773_+\|NAD(P)H:quinone-oxidoreductase	gnl\|CDD\|179647	PRK03767, PRK03767, NAD(P)H:quinone oxidoreductase; Provisional.	4.22703e-45

>NC_021191.1|WP_041832766.1|7624404_7625202_+|thymidylate-synthase
MADTQYEQLLRRVLETGTAKADRTGTGTVSLFGERLRYDLSQGFPLITTKRVHFKSVAVELLWFLRGDSNVGWLRDQGVTIWDEWADDRGELGPVYGKQWRSWPTPDGGHTDQITELLATLKRDPDSRRMIVSAWNVAQLPEMALAPCHAMFQFHVADGRLSCQLYQRSADMFLGVPFNIASYALLTHLIAAQTGLVPGDFIWVGGDCHIYNNHVDQVREQLSRDAYEFPTLQLAAAPSLFDYKYEDFTLVNYQHHPALRAPVAV
>NC_021191.1|WP_015624735.1|7624119_7624368_+|hypothetical-protein
MSTYEGTELLQKVERYEAAVKELHAAHEDVKDVLIEAILFDRWQMLGEQLGFSAENHRKEEPNRDLAQLNQQISAMSDAWSR
>NC_021191.1|WP_015624734.1|7623868_7624075_+|DUF397-domain-containing-protein
MVEKFEADLSGAVWRRSAASDGAAVEVALLDNGVAVRDSRSPDGDVLFFTPAEWDAFVGGAKDGEFDL
>NC_021191.1|WP_015624733.1|7623167_7623773_+|NAD(P)H:quinone-oxidoreductase
MANVKLAIIYYSATGTIHGMAERLQQAGEKAGAEVRLRQVPELAPEEAISSNAAWSQHFDKTKDEPKATADDVVWADAVLFGSPTRYGNIASQLKQFIDTLGPQWAQGLLADKAYAGFTASQTAHGGQESTLLALYNTIHHFGGIVVAPGYTDPLKFADGNPYGVSHVTGATNDDPVTDAEYAALDHMATRIVTIAGKLKG
>NC_021191.1|WP_015624732.1|7622818_7623094_+|glycoside-hydrolase-family-13
MIKRNKLFGNKTRVTFCLPRDTPAGTVSVVGTFNGWEPGRHELKVRRDGTRTVTLTLSPGQHQFRYLASDGVWLDDEHADGIGPHGSELLL
>NC_021191.1|WP_015624731.1|7622312_7622747_-|GNAT-family-N-acetyltransferase
MVTPEIRVASFRDLPATMLYAILKLRVDVFVVEQECAYPELDGRDTELGARHVWLADGDEILAYLRILDDGDTERIGRVVTSPSGRNGGYASRLMEHALTVIGSRPAVLAAQAHLTGFYERFGFLTDGPEYLEDGIPHVPMRRP
>NC_021191.1|WP_051167633.1|7621394_7622294_+|LysR-family-transcriptional-regulator
MPGSHGATVVVVPLPPGADLDLRLVGYFTVVAEHLNFGRAAAELRLAQPHLSRQIQRLESRLGVRLLDRTPQGSRLTPAGEAFLPEAQALLKLAGAATQAARDAEAPPLLTVGYVEGLVVTAAVRDLRRDRPGARVVTRYLAWNETDALLDRRVDVLVTRLPLPFPTETLKTTLLYEEPWVLVVPLSHPLAGRDVVTPADYAAERPAACTGAAGAFAAAEQPFPQAFPDKLQLVADGTAIAVRPAGDRRSTLREDLASIPIEGLPPCPVVVVSRPADPNPLVERFRTAAHASVAAAVAG
>NC_021191.1|WP_015624730.1|7620593_7621337_-|SDR-family-oxidoreductase
MDKYEGKRVVITGGNSGLGLATAQLLVDAGARVLITGRNQETLDAAREKLGGRVVAVRSDAAKLADIDALADRVRTEFTAVDALFVNAGISGFVPFPAVGEETYDELFAVNTKGPYFTVQRLAPLLAPGSGVVLTTSVANVKGLPMVSVYAASKAALRSMTRSLARELLPAGVRVNAVSPGPINTGILDRTMPREAVAQIEAEMTQANPMLRFGEPDEVAKAVAFLAFDATYSTGVELAVDGGASQL
>NC_021191.1|WP_015624728.1|7619876_7620581_+|chlorite-dismutase-family-protein
MSEQQTNAARINELNATIRYTMWSVFKATTPLPALRDELATEAGTLFEQLADKDVTIRGTYDVSGLRADADVMIWWHSSSSDALQDAYGLFRRTALGRHLTPVWSQMALHRPAEFNKSHLPAFLADETPRPYICVYPFVRSYEWYLLPDEERRGMLAEHGRMARGYPDVRANTVASFALGDFEWILAFEADELHRIVDLMRDLRASTARRHVREEVPFYTGRRRSLTELVANLP
>NC_021191.1|WP_041834285.1|7618482_7619880_+|NAD(P)-binding-protein
MRKRVAVIGGGIAGLAAAVRLRDRAPSDTEIIVYEQSGRLGGKLRTGELAGTRVERGAESMLMSGPDGGESAAVRFARRLGFGDTLMHPAPIPAALAIGGSLERVPAGTLVGVPGDLSLLGTVAQPAVGADRDEGHPLLADGADIAVGELVRARYGDQVADRLVDPMLGGVYAGHADRLSLATTMPALARTARTEHTLQGAVRAAQAATVRVPGRPVFAAPAGGMSSLIGAAAAASGARISLGLPVREIMPTAHGWRLLLGPVPAPQIDDVDAVVLAVPAAPAARMLSGVDLSAAATIELLDYASVALAAFAFPAGTELPELSGFLVPPGEGTLVKAATFITRKWPGLDRPDGPVVVRVSLGRAGEEERLQFDDAVLTATAHAELGRLLGRELPAPVGSWLQRWGGGLPQYAPGHLDRIALARAALSEHPGLALAGAAYDGVGLPACVASGEKAADDVLKHLEER
>NC_021191.1|WP_041832767.1|7625661_7626144_+|dihydrofolate-reductase
MTIHMIWAEARDRVIGANGAIPWHVPGEQKIFRARTTGSTVVMGRATWDSLPDRVRPLPGRRNVVLTRRSGWSAPGAEVLGSIDELLAAYDDFWVMGGAEIYTALLPHAQHIVRSRIDLAIEGDAFAPALDAQWRTAAREQHDGFVVEDLRRSGSAPPAG
>NC_021191.1|WP_041834287.1|7626109_7627147_-|uroporphyrinogen-decarboxylase
MSRVSNSPADSALVRACRGLDVPHTPVWFMRQAGRSLPEYHKVRQGIPMLESCRRPDLVAEITLQPVRRHNVDAAILYSDIVVPLAAAGIDLDIVPGTGPVVAEPVRTADDVARLRPLEPGAVDYVAESVRLLLAELGATPLIGFAGAPFTLASYLIEGGPSRNYLKTKAMMYGDPQLWHQLCSRLADITLTFLRVQAGAGVSAVQLFDSWAGALSEADYREYALPHSAAVLGGLADAGVPRIHFGVGTGMLLEAMGEAGADVVGVDWRTPLDRAAQIVGPDHSLQGNLDPAVLFAPWEVVEREARRVLEQGKAARGHVFNLGHGVLPETDPDVLTRLVELIHSA
>NC_021191.1|WP_015624738.1|7627224_7627782_+|DUF3000-domain-containing-protein
MAAPEAFTRAVAGLRAAAPREEILLEEIAAPQRLAPYAFALSATVLRDGDEVASGRLILLHDPAGHDAWRGNLRLVTLITAELEADLAADPLLPEVAWTWLTDGLDQHQAACTAIGGTITQTASTRFGELAGPEPTADLEIRASWTPTSDDLGAHLRGWCTMLASTAGLPPPGVTALNHQRASAP
>NC_021191.1|WP_015624739.1|7627753_7628467_-|YdcF-family-protein
MPSTPADDLNTLAAFLGRRDELHSSDMLILFGGCPPAGWDLAARFVRDGLAERLLLVGGEGHTTAALRSRVPAYSGATEADLMAAYLAGEHGITDVLLERESTNCGTNITYAESTLRAAGLAPRSIILMQDASMQLRMDAVFRHVWRLGAPRVSNYAGTRPRVAGRDGELVFAGAAPWAMDHWISLLMGEIPRLAPDGYGPAGKNFLAHVDIPDEVLAAHTRLARRFAVREPKPAGG
>NC_021191.1|WP_015624740.1|7628447_7629425_-|trypsin-like-serine-protease
MTTAYDPFGGPGQRRPPQDPLLSLPDHPSGEWATAARPSAPPPRIGHPRPARRDAGPYLVSPTGGAPYPVVSEPIDPPRRSRLVPLLLAVVLLAGGGFMAWRLERADSRLTGQLAASQQREGQLADRAEKLEKQLAGVFDPEAISSAVLPSVFRVRAGNFTGTAFSFGAAEEKQSYLFTNFHVVESVWDAGTKKVFLERGKDEVDATIVKVDKKKDIALLRTTKQIAGLAVAEDVVKPGQQVVVVGSPLGLEDTVTTGVVSAYRPDDTGGPSIQFDAPINPGNSGGPVVNASNEVIGLATAKARDAEGIGLAIPIKTACDAFDAC
>NC_021191.1|WP_051167851.1|7629594_7630914_+|ribonuclease-D
MTDEAPLRRRDAPDHVQDGPHDVPPDPTSGGPEAARTSVPLTAPREGTPRPVETSAELADIVARMATGSGPVAVDAERASGYRYTQRAYLVQLRREGAGTVLIDPVPLSDLQTLDAALADTEWVLHAASQDLACLAEIGMRPRRLFDTELAARLAGFERVGLAALTEQLLGYSLEKHHSAADWSTRPLPESWLTYAALDVELLTDLRDLLAAELERQGKAEWAAEEFAALVASADRPPRVRPDPWRRTSGIHRVRGARAQSRVRALWYARDGVAARRDSAPGRVLPDSAIIAAAELDPKDERALLALPGFGGRSVRRLARVWLDALDAARALSDDELPVNQPVEGPPPPHRWAERDPVAAARLQRCRQVVVATAERYTLPPENLISPDFIRRLAWSPPDEVTPAAVGDTLRGFGARDWQIGLIAEQIAAVLPDAPPAAE
>NC_021191.1|WP_015624742.1|7630972_7632169_+|thiolase-family-protein
MPRVSREVVFVDGVRTPFGKAGGMYAETRADDLVIRCIRELMRRNPQLPPEKVDEVAIAATTQTGDQGLTIGRTAALLSGLPKSVPGYAIDRMCAGAMTAVTNVAGGIAMGAYDVAIAGGVEHMGHHPMGEGVDPNPRILAEKLVDPSALVMGSTAENLHDRLSGITKERSDAFGLASQEKTAKAYANGKFQPDLVPVAIRSTEEGWGLATVDEAPRETSMEKLATLKTPFRPHGKVTAGNAAGLNDGATAALLADEETARELGLPIAMRLVSYGFVGVEPEIMGYGPIPSTEKALRLAGLTIEDIGLFELNEAFAVQVLAFLDHFGIADDDPRVNPWGGAIAIGHPLASSGVRLMTQLARHFEEHPEVRYGLTAMCIGIGMGGTVIWENPHFEGADK
>NC_021191.1|WP_015624743.1|7632165_7634238_+|3-hydroxyacyl-CoA-dehydrogenase-nad-binding-protein
MSTALPDYPNEVVTQALVRLVKVPGLTKPAALITLDNGLDYKKPNSFGPAGLAALDEAITKATEADPAFIALTGKPYIFCVGADITGMPFLTQRDQAVALGELGHRVFARLRASSIPTFAFINGAALGGGLEVSLHCHYRTVSGGAAALGLPEVAIGLVPGWGGSQLLPNLIGIPGAAQVILQNPLTQKVLKPQQARELGIADALFEPADFLERSLEWAAGVVQGDVQVERPEVDKDMWDGVLFFAKQQLDERLHGAVPSANKALELLALAKDATFEDGTAAETRALADLIMGDESRASLYAFDLVQRRAKRPVGVPDKDLARRITKVGIVGAGLMASQLALLFVRRLQVPVVLTDLDQTRVDKGVEYVHSQIAKTVSKGRMDEGTAAKLRGLVTGSVDKAAFADADFVIEAVFENLDLKKQIWAELEKIVSPGTVLATNTSSLSVTEMAADLEHPERVVGFHFFNPVAVLPLLEIIKGGRTDDATLATAFAVGKDLRKSCVLVKDAPAFVVNRLLTRFTSEIFAAIDAGTPLDTVDSALDPLGLPMRPIALLQLVGPAVAYHVGETLHEAFPDRFAVSPNLARIVEAGKPLMLDDEINPEVVALIEAGDKPLTADEVRQKALDALAEETRLMLDEGVVAEAQDIDLCMLLGAGWPFHLGGVTPYLDRSGTAERVTGKRFLPQGVASLPA
>NC_021191.1|WP_157408611.1|7634425_7635478_+|hypothetical-protein
MSQPPNQPPYPGEPHNQPGSGQPYGSPYGAQPPSSGQPYGAQPPYGAEQPASGQPYGAQPPGGDQPYGAPGPYGTPGYGAPGAYGQPGSYQGQPNPDVPASVPPGYPPAPDYPQQGGYGQPGAPFEQPPKKKSKVLPIVLISLALLLVLCVGGGTAIFLAAKNSDDDSATATSTTAPATDSTATPDATTTTEPAEDSTSNITVVEPKTLGGRPKLTDPQFAGAADELEQGLKEVPDATETVGALYGDVSKQDIVIVAAAAAKVDDPEKELDNTFLGAGIGGLKLTGITSASPGSLGGAAKCGKGAAGGADLIMCGWADKGSIGWVIWYFKSMSSAKAEFPKLRAQVEKKS
>NC_021191.1|WP_084504604.1|7637024_7638224_-|HAMP-domain-containing-histidine-kinase
MRPTLRLRLTLLNGILLVGAGAILVLLAWLLVGDALHPSDQLQPGTQVVLSTGERLDALTWQTDLVARASQELLVKGLIALVAIGIIGIAGAYAVAGRALRPLHNVTATARRLGEETLDERIRYSGADDEVAELARTFDAMLDRLAGAFESQKRFVANASHELRTPLAVMRTEIDVTLSDDEADVAEYRRMAKVVRNASERANGLVDALLVLARSEAQSGRRLVRKVPADLATSVYNALSAVKAEAERLKLEVTTDLQAANVVGDPSLLDRLAGNLIENAIRYNHLMGKLWLRTESVDGQARLVVGNTGFEVDPTDVPGLFEPFRRGGWERTGSRGSGLGLSIVRAVCDAHGGTVSAVAQPGGGLEVTVSLPGADTTPVVAASATVPRAKGLGVAASGS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_20

7799751-7799863

Orphan

Consensus_repeat	Method
CAGCCCGTTGTCCAGTTGCCGGGCACCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_20

>merge|NC_021191|20|7799751-7799863|CRISPRCasFinder
CAGCCCGTTGTCCAGTTGCCGGGCACCGGAGGCGAGCTGGAAGATGCCGCCCCGAAGATCCCGGGCACCGGAGGCCGCGTCGGCAGCGCCGTTGTCCAGTTGCCGGGCACCGG

>NC_021191|20|17|7799751-7799863|CRISPRCasFinder
CAGCCCGTTGTCCAGTTGCCGGGCACCGG	AGGCGAGCTGGAAGATGCCGCCCCGAAGATCCCGGGCACCGGAGGCCGCGTCGGC
AGCGCCGTTGTCCAGTTGCCGGGCACCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_041832785.1\|7801792_7802749_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274812
NC_021191.1\|WP_015624897.1\|7796191_7797076_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226631
NC_021191.1\|WP_041832788.1\|7807756_7808968_-\|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	unknown	unknown	gnl\|CDD\|235472
NC_021191.1\|WP_015624904.1\|7803493_7804333_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379120
NC_021191.1\|WP_015624890.1\|7788274_7789636_-\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|365919
NC_021191.1\|WP_051167643.1\|7795620_7796172_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238042
NC_021191.1\|WP_015624893.1\|7793498_7793897_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133394
NC_021191.1\|WP_041832783.1\|7791025_7792555_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|273331
NC_021191.1\|WP_015624901.1\|7801093_7801666_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224045
NC_021191.1\|WP_157408619.1\|7804352_7805303_-\|DUF4037-domain-containing-protein	unknown	unknown	gnl\|CDD\|379078
NC_021191.1\|WP_015624909.1\|7809869_7812002_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_021191.1\|WP_015624899.1\|7798335_7798920_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_021191.1\|WP_015624898.1\|7797072_7798143_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224582
NC_021191.1\|WP_157408956.1\|7802750_7803329_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_021191.1\|WP_084504608.1\|7794838_7795702_+\|DUF998-domain-containing-protein	unknown	unknown	gnl\|CDD\|377627
NC_021191.1\|WP_015624907.1\|7806506_7807757_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|100084
NC_021191.1\|WP_041832787.1\|7805299_7806472_-\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|234737
NC_021191.1\|WP_084504335.1\|7809070_7810012_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377085
NC_021191.1\|WP_015624891.1\|7789638_7790985_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NC_021191.1\|WP_041832784.1\|7794048_7794867_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|212492

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_041832785.1\|7801792_7802749_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274812	TIGR03841, F420_Rv3093c, probable F420-dependent oxidoreductase, Rv3093c family. This model describes a small family of enzymes in the bacterial luciferase-like monooxygenase family, which includes F420-dependent enzymes such as N5,N10-methylenetetrahydromethanopterin reductase as well as FMN-dependent enzymes. All members of this family are from species that produce coenzyme F420; SIMBAL analysis suggests that members of this family bind F420 rather than FMN. [Unknown function, Enzymes of unknown specificity].	1.04749e-94
NC_021191.1\|WP_015624897.1\|7796191_7797076_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226631	COG4152, COG4152, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	4.65649e-105
NC_021191.1\|WP_041832788.1\|7807756_7808968_-\|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	gnl\|CDD\|235472	PRK05447, PRK05447, 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional.	0
NC_021191.1\|WP_015624904.1\|7803493_7804333_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379120	pfam13312, DUF4081, Domain of unknown function (DUF4081). This domain is often found N-terminal to the GNAT acetyltransferase domain, pfam00583 and FR47, pfam08445.	1.52964e-42
NC_021191.1\|WP_015624890.1\|7788274_7789636_-\|aldehyde-dehydrogenase	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	0
NC_021191.1\|WP_051167643.1\|7795620_7796172_+\|hypothetical-protein	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	4.6976e-05
NC_021191.1\|WP_015624893.1\|7793498_7793897_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133394	cd04766, HTH_HspR, Helix-Turn-Helix DNA binding domain of the HspR transcription regulator. Helix-turn-helix (HTH) transcription regulator HspR, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	3.88873e-12
NC_021191.1\|WP_041832783.1\|7791025_7792555_-\|amino-acid-permease	gnl\|CDD\|273331	TIGR00907, Choline_transport_protein, amino acid permease (GABA permease). [Transport and binding proteins, Amino acids, peptides and amines].	5.60681e-119
NC_021191.1\|WP_015624901.1\|7801093_7801666_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.85755e-16
NC_021191.1\|WP_157408619.1\|7804352_7805303_-\|DUF4037-domain-containing-protein	gnl\|CDD\|379078	pfam13228, DUF4037, Domain of unknown function (DUF4037). This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is approximately 100 amino acids in length. There is a single completely conserved residue P that may be functionally important.	3.69322e-33
NC_021191.1\|WP_015624909.1\|7809869_7812002_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	3.00723e-91
NC_021191.1\|WP_015624899.1\|7798335_7798920_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.2655e-16
NC_021191.1\|WP_015624898.1\|7797072_7798143_+\|ABC-transporter-permease	gnl\|CDD\|224582	COG1668, NatB, ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism].	1.03417e-20
NC_021191.1\|WP_157408956.1\|7802750_7803329_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.52573e-24
NC_021191.1\|WP_084504608.1\|7794838_7795702_+\|DUF998-domain-containing-protein	gnl\|CDD\|377627	pfam06197, DUF998, Protein of unknown function (DUF998). Family of conserved archaeal proteins.	3.78899e-06
NC_021191.1\|WP_015624907.1\|7806506_7807757_-\|PDZ-domain-containing-protein	gnl\|CDD\|100084	cd06163, S2P-M50_PDZ_RseP-like, RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog RseP is involved in the sigmaE pathway of extracytoplasmic stress responses. Also included in this group are such homologs as Bacillus subtilis YluC, Mycobacterium tuberculosis Rv2869c S2P, and Bordetella bronchiseptica HurP. Rv2869c S2P appears to have a role in the regulation of prokaryotic lipid biosynthesis and membrane composition and YluC of Bacillus has a role in transducing membrane stress. This group includes bacterial and eukaryotic S2P/M50s homologs with either one or two PDZ domains present. PDZ domains are believed to have a regulatory role. The RseP PDZ domain is required for the inhibitory reaction that prevents cleavage of its substrate, RseA.	7.61466e-48
NC_021191.1\|WP_041832787.1\|7805299_7806472_-\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl\|CDD\|234737	PRK00366, ispG, flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.	0
NC_021191.1\|WP_084504335.1\|7809070_7810012_+\|hypothetical-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	8.92469e-14
NC_021191.1\|WP_015624891.1\|7789638_7790985_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	4.26772e-134
NC_021191.1\|WP_041832784.1\|7794048_7794867_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|212492	cd05327, retinol-DH_like_SDR_c_like, retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs. Classical SDR subgroup containing retinol-DHs, LPORs, and related proteins. Retinol is processed by a medium chain alcohol dehydrogenase followed by retinol-DHs. Pchlide reductases act in chlorophyll biosynthesis. There are distinct enzymes that catalyze Pchlide reduction in light or dark conditions. Light-dependent reduction is via an NADP-dependent SDR, LPOR. Proteins in this subfamily share the glycine-rich NAD-binding motif of the classical SDRs, have a partial match to the canonical active site tetrad, but lack the typical active site Ser. This subgroup includes the human proteins: retinol dehydrogenase -12, -13 ,and -14, dehydrogenase/reductase SDR family member (DHRS)-12 , -13 and -X (a DHRS on chromosome X), and WWOX (WW domain-containing oxidoreductase), as well as a Neurospora crassa SDR encoded by the blue light inducible bli-4 gene. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.66848e-70

>NC_021191.1|WP_015624899.1|7798335_7798920_-|TetR/AcrR-family-transcriptional-regulator
MDGRTRRREDTRQRLYEAAVELIAEQGFSATTVDDIALRANVAKGTVYYNFASKTALFEDLLRHGIGLLTDSFRAAVEGLPPREAVDALIRAQLEYIRKYRAFAQLLLSEMWRTNREWQQTLILLREQAISVIAETVQSGVDAGDLPPDLDVRVASSALFGVGLVVAVDWLVFQPDRPIEDVEQSLLAIIRRVA
>NC_021191.1|WP_015624898.1|7797072_7798143_+|ABC-transporter-permease
MTTLAAAKLVATREIRMKLRDKTFIFSTVFFLLIAVASTVLPALLEGGATKVAVADSAIATVLQRADLDVRTVPDDAAAERLVRAGDVDAAVVSGPRVLAMDETPSDVVGALSTAPPVQLLDPDTVNPFLKFIVPFALAFLFFVTSFTFGMQIAQSVTEEKQTRIVEILVSSIPVRALLAGKVAAITLLAFGQIALVALVTFIGMQIADVDTEVISLVGPAIGWFLPFFVLGFVMLATLWAGVGALAGRQEDLAGASTPLQMAVMLPFFAVVFLTDNEPVMRILSYVPFSAPIAMPVRLFNGEAAAWEPVISLVVLAISTLLLLRVGARVYEGSLLRTNGRTTFAAAWRTRSTIGS
>NC_021191.1|WP_015624897.1|7796191_7797076_+|ATP-binding-cassette-domain-containing-protein
MLSVDAISRSFGDRQVLKDVSFDVGAGRMTGFVGANGAGKTTTMRIMLGVLGADSGEVRWQDRPLTRELRQRFGYMPEERGLYPKMTIADQISYLGRLHGMTAADARRSTDALLERLSLTDRAGDMVEKLSLGNQQRVQIAAALVHEPEVLVLDEPFSGLDPLAVDVVVGVLRDRAAAGAPVLFSSHQLDVVERLCDDLVIIADGSIRAAGSRQQLRASHALPRFRIETDGDAGWLRDQPGVTLIELDGGQAVFDLAPGTDDQDLLRTALARGPVRSFGPVSPSLAEIFREVSQ
>NC_021191.1|WP_051167643.1|7795620_7796172_+|hypothetical-protein
MEGTEPEPQSGSLEDRVSELERRFTELIKARSPVPPAPPTAKPVDFWALDGLRARLDDDDGMGAVVYTGIVHLPTGEHYDWQLGTAVDDLMAADWSHWATTLAALGHPVRLLLLRRVLAGIRTAAELAADEALGTTGQLYHHLRQLVNAGWLHSSARGHYSVPAERVVPLLIVLSGARSRAEI
>NC_021191.1|WP_084504608.1|7794838_7795702_+|DUF998-domain-containing-protein
MPELAPVITTVRPTTAFDHPPGSGACLSVNAMPEDHRSRTRRPGGAAGLAALAGLAVLAGASTMLVTLVAAPGSWLLGYVSEAGTAGRPLAVAYRSGLVLLAAGVALLGLALRPTSRPVAALLGVAAFLASVSGVVPCTNQCPLPPFEPTTVSDVVHTVASIIGMVVLAGVMAIVAFSSLLRPSTSARFRPDLFRPAERRLSAVAVLVTVPLGATLGLAMLLIGRGPVSAIVERLALFVAVSWLVGMAHLTLLRSSVKIEPWKERNPSHSPDRSKTESPSWSDVSPS
>NC_021191.1|WP_041832784.1|7794048_7794867_-|SDR-family-NAD(P)-dependent-oxidoreductase
MVITGASSGIGLAAATALARGGDEVVLLGRDPGRLRDAVATVREAGGRTPASYRADFAVLDEVRATGQRVAAEHERIHVLVNNAGQLAPARRLTADGFDPGMQVNHLSGFLLAHLLVERLRAAATEAEPARMVTTGSAAEAWGTLDVDRPGRRQLSPWLAYGAGKQANLLFTIEAARRWTPFGIVPTCFFPGLIRSRFGRRSPLWALAQLAPMVFQTAERGADTLVWLATDRAALVPGGYFARRRPMIATGRSTDPERAHRLWEASVAAVGL
>NC_021191.1|WP_015624893.1|7793498_7793897_+|MerR-family-transcriptional-regulator
MNAMLDDADFPAYTMGRAADLIGVTPAFLRSLGTAGLIEPERSLGGHRRYSRHQLQLASRVRQLLDEGMLLTAACRIVTLEDRLEAAHRRILDLGGTLTPDDNADVPIPTHLDIAAPKYYPSPRTTRSPSAL
>NC_021191.1|WP_041832783.1|7791025_7792555_-|amino-acid-permease
MSADPVPSTDEERLAQLGYQQELHRRLSGFSNFAVSFSIISILAGAITSYGIAMTAGGPIAITLGWLFVGVMVTFVALAMAEVCSAYPTAGALYWWAAALAKRRKAAWAWFVGWFNFLGEVAVTAAIDFGAAITTAAFLGLTFDMTVTAGRTFLIFLVIIVVHGLLNTFGVSLVRLLSDVSAWWHLVGVAVIVGVLAIVPDSHKPLSEVFTEVHNSTGFGFAGAGAYAVLIGLLMAQYTYTGYDASAHVAEETHDAARAAPRGIVMSVVVSVIAGFVLLVAITWSIQDYAAEQATDLGLPPAQIFIDAVGHDLGTFLLFICMVAQWFCGMASVTANSRMAYAFARDGALPGSRWWKQVNPRTGTPTNSIWLCVTISTILVLPSLWNTTAYLAATSIAVIGLYIAYVGPVLLRRLNPDFQPGPWHLGRWSAPIGWLAIGWVVVICVLFVLPTASPITASTFNYTIVAVLVVVGAAAIWWFASARKWFTGPKQNLIEKAAHGEQTLPNAPE
>NC_021191.1|WP_015624891.1|7789638_7790985_-|glutamine-synthetase
MDLEDLAVAVDNGSIDTVLLALTDMQGRLQGKRLHGRYFMDEVVGSGSEGCNYLLAVDVDMNTVEGYALSSWHSGYGDFVMKPDFRTLRRVPWQPGTAMVLADLETTDGQAVYASPRQILRRQLDRLAERGLTAYAGTELEFLLVKDTYEQAWAKNYRDLVPANQYNVDYSLLGTARVEPLLRRIRNEMAGAGLVPESAKGECNLGQHEIAFRYTDALACADHHVIYKNGAKEIAAQEGMALTFMAKPNEREGNSCHIHFSLRDADGQSAMLGDGPAHLSVTGRQVLAGLLATMREFSLLFAPNINSYKRYQPGSFAPTALRWGVDNRTCALRIAGHGQGMRVENRVPGGDVNPYLAIAALVAGALHGIEHELSLEDELKGNAYEDSSAPRVPTTLREALELWERSPVASSAFGDEVVAHYANMAKVELTAFEAAVTDWELRRGFERL
>NC_021191.1|WP_015624890.1|7788274_7789636_-|aldehyde-dehydrogenase
MDSFDVINPATGGLLEAVPLHGVAETDAAIERAQRAFESWRQVAPGDRARLLRRFAAVVDEHVEELAQLEVANAGHTIGNARWEAGNVRDVLDYYAAAPERLSGRQIPVAGGLDVTFHEPLGVVGIIVPWNFPMPIAGWGLGPALAAGNTVVLKPAELTPLTALRLAELALVAGLPEGVFTVLPGRGDVVGQRFVTHPAVRKVCFTGSTRVGKAVMAGCAEQVKRVTLELGGKNANIVFADADLEKAAASAPGGVFDNAGQDCCARSRLLVQDTVYDRFLALLEPAVKAFRVADPRLDTAEMGPLISAAHRDKVASYTAEGEVAFSGSAPGGDGWWFPPTVLLARSPADRHWREEVFGPVLSVLPFHDEQEAVALANDTDYGLSGSIWTRDLGRALRVSRGVDSGNLSVNSHSSVRYWTPFGGMKQSGFGRELGPDAVLGFTDVKNVFINTES
>NC_021191.1|WP_015624901.1|7801093_7801666_-|ATP-binding-cassette-domain-containing-protein
MPVLTATAAGVRHHRRWLFHDLDVTVSPGDKVAIIGPPGSGRTTVLLALTRRFRLSAGQVQLDGAAALGHVPGVSEPENVLTAAELVRERSLLEGRPPRQQVDWHGLDPALRGFELSPYQRQVLGLIQAQVAQPQLIALDAIDEGLNAAEREQLQALIDEIAATGVAVLMTARDIDETRVATVIRLGGDQ
>NC_021191.1|WP_041832785.1|7801792_7802749_+|LLM-class-F420-dependent-oxidoreductase
MTVPLGGVPLAEHAAVYRTLIEAGFTDLWSSEVNGTDAFTPLTLASVWQPQARLGTAITPVFTRGPGLLAMTAAALAEAAPGRFQLGIGASSPVVVGDWNAAEFTKPYARSRDMLRFLKTALAGEAVDQSFETFRVRRFRLERPPTTPPQLLLAALRPGMLRLAAAEADGVILNWLAATDVAQALAEAKTSKPDFDVVARIFVCPTEDRDYARTAGRRMIAAYLTVPAYREFHRWLGREPALAPMWQAWAAGDRRGALAAIPDEVVDELIVHGSPEQCREHVTRYAEAGVTVPVMALIPTPDMAEGGGHDVLAALGRR
>NC_021191.1|WP_157408956.1|7802750_7803329_-|PadR-family-transcriptional-regulator
MRGFGFPPGFPFGGPGQGGFGGHGGFGGWGEPGGGPGGSRGGRRGGRGSRPNVRPAILALLLERPMHGYEMIQELESRTGGIWRPSPGSVYPTLQLLEDEGLIEAEAAGGRKRFSLTEAGRAEAQAAAENPPWTQFSDDTMSQVADFRDAAMGIMSALRQVGFNGTPEQRQRALEVLNETKRKLYAILADSE
>NC_021191.1|WP_015624904.1|7803493_7804333_+|GNAT-family-N-acetyltransferase
MLTVPLRQLGESERATVERILDQDPYAGAQIAERVAAHGLNWWRSDGRVFGYGTTHRVESLCWSGAHLVPVCATPPAVAAFAELLGAEPRICSSIIGRSEAVLDLWDRLGSHWGPARDVRPLQPLLVADREAPVAPDPEVRLVRSTEVDQLFPAAVAMYTEEVGVSPLLDDGGRGYKRRIAELVRGKRAYARFLGDRVIFKAELAIVTSRTTQIQGVWVDPEFRGRGLAAAAMATVLQDALRRVAPTVSLYVNDYNTAARHVYARCGFIQQGSFATVLF
>NC_021191.1|WP_157408619.1|7804352_7805303_-|DUF4037-domain-containing-protein
MTLPAFTPGVRLCRLFYEEAVRPLLDRAFPGLPHAAARVGPGSDVLGFDTERSTDHDWGPRLELFLAAADVSRHGAELSALFSARLPVSFRGWPTNFEPAGARVRVMTPTSGPVAHRIDITDVATWSVAVLGFDATREPGPAEWLTTPSQRFAEATGGAVFHDDSGELTRLRSRLRWYPDDVWRALLAGQWSRIAEEESFVGRTAEAGDELGSRVIAARLVHELMRLELLLTRRYPPYSKWLGTAVGPAPGLLRVLDARDASERQAALCTAYEAAARLQNATGLAEPVDPVCRPFFDRPFRVLDAGRFAAALRAVG
>NC_021191.1|WP_041832787.1|7805299_7806472_-|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MTAVSLGMPAVPPPPLAPRRQSRQINVGGVLVGGGAPVSVQSMTTTLTSDINATLQQIAELTASGCQIVRVAVPSQDDVEALPAIAKKSQIPVIADIHFQPKYVFAAIDAGCAAVRVNPGNIRQFDDKVKEIAKAASGAGVPIRIGVNAGSLDKRLLEKYGKATAEALVESALWECSLFEEHGFRDIKISVKHNDPVVMIRAYRQLAEQCDYPLHLGVTEAGPAFQGTIKSSVAFGALLAEGIGDTIRVSLSAPPVEEIKVGQAILESLGLRERGLEIVSCPSCGRAQVDVYTLAEQVTAALEGFPVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGQVIKTVPESIIVETLVEEALRLADDMGAELPDELRELLPGPQVTVH
>NC_021191.1|WP_015624907.1|7806506_7807757_-|PDZ-domain-containing-protein
MLYWLGTAAFALAILISVSLHELGHMITAKRFGMKVTQYFVGFGPTIFSFRRGETEYGLKAIPLGGFCKIVGMTPQDDDVLPADQPRAMWRFPVWKRTVVMSAGSITHFILAIVAIWFAAVFVGLPNPAYPQTAAEERAVPAKISVGECVQIVLTDAGCTAGTDPAAPAAAAGLKTGDVVTRVGATPVQNYGQLTDAIRAIPPGEVEFGYTRNGVAGVAKVKLIAAQRAPIDDPDGKVSEVAVAGLGPEVDIPTLVTYGPGEAVGETFSYSWTIVKGSLAALGRVPEKIPALWHSITGNERDPDTPISVVGASRLGGEAIQRGVPEVFLMIFISLNVFIGLFNLLPILPVDGGHIAIAWFERVRSWLYARLKRPDPGRVDYYKLMPLTYAVILIGGAFTLLTITADVINPISIFSR
>NC_021191.1|WP_041832788.1|7807756_7808968_-|1-deoxy-D-xylulose-5-phosphate-reductoisomerase
MAGMRELVLLGSTGSIGTQAIDVIRRNPGKFRVVGLGAGGGNVALLATQALELGVDVVGVAASSAVQDLQLAFYAEAQQRGWATGDFKLPKIVAGPEAMTELAQWPCDVVLNGVVGSLGLAPTLAALRSGRTLALANKESLVAGGPLVKAAVQRPGQIVPVDSEHSALAQCLRGGSEREVRRLVLTASGGAFRDRRRSELSNVTPEEALKHPTWDMGPVVTINSATMVNKGLEVIEAHELFDVAYDDIEVTVHPQSVLHSLVEFTDGSTLAQASPPDMRLPIALALGWPDRVPEAAPAVDWTLAHNWELRPLDNDAFPAVELAKAAGRAGNCRPALYNAANEECVAAFMAGRLPFLGIVDTVSAVLAAAPDFGEPSTVEAVLAAETWARAQAQRMIATAAEGA
>NC_021191.1|WP_084504335.1|7809070_7810012_+|hypothetical-protein
MRRLRRLVAASFRPLRGRDLALHAAAVTFYAGIAVVPVALLAIWLTGLVAGADRVRELTGHTIAALPDAIGAPQALARLIDAGLHLTPALALASLLPATFYGEGLRRAFVSLREPGESLVGWRGRLLWLPLLAAAPALLLSLFLALPVTSGLWVRGGWWSVLGVVLSFLAAWLVLTPVVIWVYRGVAPGRPEWLSTVLVGSFTAANISGFLHGFVLFCSLPLDLGVPFGNFTEIGGMVAVGLWLYLFHVIILAGYAATQSASAYQRARRIRTLAAEQPEPHESRSGCRTGPESPAPTSSTGPAAASSPAPAAP
>NC_021191.1|WP_015624909.1|7809869_7812002_-|MMPL-family-transporter
MFGWWGETVGRIRWWVVAAAGVLVVAGATWGAGVFGALTGGGYDDPGSESNRAAAAIARELGQRDPDLIVLWSSDAATVGDPSFRAAVRAAAARIRERPDVEQVAAYTDPQAPATLVSTDRHATYAAVYLRAGDEDGKAAAYHRIAPDFSVDGLKTQVGGLVAFTDEANTQTEKDITRAEIFSLPVLFVLLILIFRGLVAALSPLVIGGLAILGAFVAVRALTYVTDISVFAINVITLLGLGMAVDYSLFVVSRFREELAHGHDVPAAIRTTVATAGRTVAVSGLTIVLALSSLLIFPQPFLGGMAIGGMAAVLVAMLAALTVLPAALSLVGRRIDKLRLPLPQRRHAEGSGTWARVAHSVMKRPVVYAVSVLVVLVAFAAPFLRVEFGGFDERVLPAGSSARVVGERLDTQFPGGGENPVTVFVRGSAGDLPGRIAAVPDVTSATVTAQRGPASLITVTYPKDLPGAQARDIAAGIRDLTPPVGTQVLVGGRPAVDLDLLESLSARLPLMALIMAIATMLLLFLAFGSVLLPIKAVLMNAVSIGASFGVVVFIFQDGHFENLLRFESTGYIEPSNMILVLAVLFGLATDYEVFLLSRVREEWDRTGDNTEAVATGLQHTGGIITAAALLLITVVAGFATGSVTVIKTIGVGMIVAIVVDATLVRALLVPATMRLLGRWNWWAPGILGRFYTRYGIHEAPAAPQPESVSV

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NC_021191_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021191_21

9197809-9197909

Orphan

Consensus_repeat	Method
CGACCGCCCACCGACGCGGAGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021191_21

>merge|NC_021191|21|9197809-9197909|CRISPRCasFinder
CGACCACCCACCGACGCGCGACCGCCCACCGACGCGGAGCCCGCGCCGACCGGGGCGCGCCCGGCACCCACGGAGGCACGACCACCCACCGACGCGGAGCC

>NC_021191|21|18|9197809-9197909|CRISPRCasFinder
CGACCACCCACCGACGCGCGACC	GCCCACCGACGCGGAGCCCGCGCCGACCGGGGCGCGCCCGGCACCCACGGAGGCA
CGACCACCCACCGACGCGGAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021191.1\|WP_007073789.1\|9187580_9187820_-\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|178997
NC_021191.1\|WP_015626259.1\|9207172_9207865_+\|RNA-polymerase-sigma-factor-SigM	unknown	unknown	gnl\|CDD\|236604
NC_021191.1\|WP_015626258.1\|9205570_9207121_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270875
NC_021191.1\|WP_157408675.1\|9191341_9193387_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227904
NC_021191.1\|WP_015626246.1\|9189053_9190028_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NC_021191.1\|WP_051167717.1\|9202574_9203525_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_015626247.1\|9190153_9190930_+\|deoxyribonuclease-IV	unknown	unknown	gnl\|CDD\|179214
NC_021191.1\|WP_015626260.1\|9207861_9208713_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_041833030.1\|9201145_9202576_-\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|131739
NC_021191.1\|WP_015626245.1\|9187859_9188405_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|236092
NC_021191.1\|WP_015626257.1\|9203576_9205394_+\|murein-biosynthesis-integral-membrane-protein-MurJ	unknown	unknown	gnl\|CDD\|240528
NC_021191.1\|WP_015626251.1\|9198287_9198758_-\|DUF5318-domain-containing-protein	unknown	unknown	gnl\|CDD\|379953
NC_021191.1\|WP_041833029.1\|9200673_9201141_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|223427
NC_021191.1\|WP_157408674.1\|9180155_9180509_+\|hypothetical-protein	unknown	unknown	unknown
NC_021191.1\|WP_014448192.1\|9188473_9188764_-\|30S-ribosomal-protein-S6	unknown	unknown	gnl\|CDD\|179034
NC_021191.1\|WP_051167716.1\|9183145_9187027_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
NC_021191.1\|WP_015626252.1\|9198913_9199537_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_021191.1\|WP_041834568.1\|9199557_9200637_+\|inositol-3-phosphate-synthase	unknown	unknown	gnl\|CDD\|132491
NC_021191.1\|WP_015626241.1\|9180532_9181948_-\|replicative-DNA-helicase	unknown	unknown	gnl\|CDD\|273206
NC_021191.1\|WP_015626244.1\|9187116_9187566_-\|50S-ribosomal-protein-L9	unknown	unknown	gnl\|CDD\|234659

Protein	Function_ID	Function_description	E-value
NC_021191.1\|WP_007073789.1\|9187580_9187820_-\|30S-ribosomal-protein-S18	gnl\|CDD\|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	1.91184e-33
NC_021191.1\|WP_015626259.1\|9207172_9207865_+\|RNA-polymerase-sigma-factor-SigM	gnl\|CDD\|236604	PRK09643, PRK09643, RNA polymerase sigma factor SigM; Reviewed.	6.46854e-84
NC_021191.1\|WP_015626258.1\|9205570_9207121_+\|protein-kinase	gnl\|CDD\|270875	cd13973, PK_MviN-like, Pseudokinase domain of the peptidoglycan biosynthetic protein MviN. The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This family is composed of the mycobacterial protein MviN and similar proteins. MviN is an integral membrane protein that is essential for growth and is required for cell wall integrity and peptidogylcan (PG) biosynthesis. It comprises of 14 predicted transmembrane (TM) helices at the N-terminus, followed by an intracellular pseudokinase domain linked through a single TM helix to a carbohydrate binding extracellular domain. Phosphorylation of the MviN pseudokinase domain by the PG-sensitive serine/threonine protein kinase PknB recruits a forkhead associated (FHA) domain protein FhaA, which modulates local PG synthesis at cell poles and the septum. The MviN pseudokinase forms a canonical receptor kinase dimer.	3.35819e-58
NC_021191.1\|WP_157408675.1\|9191341_9193387_+\|hypothetical-protein	gnl\|CDD\|227904	COG5617, COG5617, Predicted integral membrane protein [Function unknown].	2.83626e-05
NC_021191.1\|WP_015626246.1\|9189053_9190028_-\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	6.12467e-07
NC_021191.1\|WP_015626247.1\|9190153_9190930_+\|deoxyribonuclease-IV	gnl\|CDD\|179214	PRK01060, PRK01060, endonuclease IV; Provisional.	1.53846e-111
NC_021191.1\|WP_041833030.1\|9201145_9202576_-\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0
NC_021191.1\|WP_015626245.1\|9187859_9188405_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	2.56776e-94
NC_021191.1\|WP_015626257.1\|9203576_9205394_+\|murein-biosynthesis-integral-membrane-protein-MurJ	gnl\|CDD\|240528	cd13123, MATE_MurJ_like, MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.00448e-89
NC_021191.1\|WP_015626251.1\|9198287_9198758_-\|DUF5318-domain-containing-protein	gnl\|CDD\|379953	pfam17249, DUF5318, Family of unknown function (DUF5318). This family of unknown function is mostly found in Actinobacteria.	4.2986e-82
NC_021191.1\|WP_041833029.1\|9200673_9201141_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	7.41942e-45
NC_021191.1\|WP_015626244.1\|9187116_9187566_-\|50S-ribosomal-protein-L9	gnl\|CDD\|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	2.46639e-67
NC_021191.1\|WP_014448192.1\|9188473_9188764_-\|30S-ribosomal-protein-S6	gnl\|CDD\|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	2.83423e-40
NC_021191.1\|WP_051167716.1\|9183145_9187027_+\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	9.2204e-10
NC_021191.1\|WP_015626252.1\|9198913_9199537_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	5.68901e-16
NC_021191.1\|WP_041834568.1\|9199557_9200637_+\|inositol-3-phosphate-synthase	gnl\|CDD\|132491	TIGR03450, mycothiol_INO1, inositol 1-phosphate synthase, Actinobacterial type. This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.	0
NC_021191.1\|WP_015626241.1\|9180532_9181948_-\|replicative-DNA-helicase	gnl\|CDD\|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0

>NC_021191.1|WP_157408675.1|9191341_9193387_+|hypothetical-protein
MFDTPPSGRHAAERPARRFRRGKAKRDETAAMPVPDFTGPQEAVPAGKAAPGEQAAPSEQPAAPADEKAPGRFRRTKKAALPTDRPPGAPPDPWSAFATTPVEREPGRFRRALHRAGRGLRHEYALVSYAALLLAVVLTWPTLRYPLHTVPQDTGDPSRQAWQVAWAGHVLLTEPARLWQANAFFPEHYSYAFGDGLLGYAPAGMLGDGPIAAVLRYNILFVLAHALLAVGAYALVRQLGAGRTGAVVAAVAFTYAPWRLAQEGHLDIVSAGGIPLALAMLARGHGYSLRYGFRPDRRRTGWAVAGWGVAVWQLTLGFSLGLPFAYVLAALILTVAITVLVRRLRRRRQGAVLGWRLLVTDLLGALIFAGVGALIALPYFRVPATAPAGTEIAFFSPPVRSLLIGPAESRIWGAPHAAVRESLSWPAEMSLLPGFVLYALALLGLIFSVWRWWQRLVLLAGAVVSAIVMLGTTFFEGHWTYLPLFGHLPASFGARIPGRLMLWVTLFLALLAAGAVAEFVRRAEGFAATRTAHPWPGPWLRLATFVPLLLVLVEGWNATAHPVVPDQPAAMRTVQGPMLVLPTAALADQTIMLWSTTKFQQIANGSGGFAPRRQSDLRRSVSSFPDAASVQYLRSLGIGTVLLLRSEAAGTPWERSGDIPVDSLGITRQDLDTDSVLFRLG
>NC_021191.1|WP_015626247.1|9190153_9190930_+|deoxyribonuclease-IV
MRIGAHVDPAAPLDAAAARGADAVQFFLADPQGWKSPAARPDAEELRASDVDIYIHAPYVINVATLNNRIRIPSRKLLLTHARAAAAIGARALIVHGGHVTAGDDIAVGFDNWRKTFAYAQEEGGLPLPVLIENTAGGDHAMARRFDNLARLWDAVGEFGAGFCLDTCHAHAGGEDLIGIVDRVKAITGRIDLIHANDSKDSFDSGRDRHDNLGSGKIDPELVVAAIRASGAPAIVETPGGTEGQAADIALLRAKAGS
>NC_021191.1|WP_015626246.1|9189053_9190028_-|hypothetical-protein
MSRHIRNRVTALALGGFLLGTAFVTTGTAQAGQIQSGAHQVVFGGGGTLGRPCRSTPSVASLTIPAESTVRVVNRTGRRAKLLLNGKAQGTVADHAVTEVVFRRGITAVTLDPRCAITEKSTPVVVTTSPSASPSDGGDMPAPPEIPGDDEPSTPAGTDEPPTSEPEDPGTVPEPSQPQTPPVSTARPPTSRPVPPGSVVTTHSAAPAGPPGGNAAPPRTKTVHGTSGSTVSSYADVVLGNGQAAAAPVPGTDVPVATTEAAPAPQAGPTRRVAAAEPVAAMAPLPDSRPIGLLAVIAAVCVLGVGTGSIRAFVSQRASRTSVA
>NC_021191.1|WP_014448192.1|9188473_9188764_-|30S-ribosomal-protein-S6
MRHYELMVILDPSLEERTVAPSLDQYLNVIRTAGGSVEKLDVWGRRRLSFEINKKAEGIYAVVDLQATPEAVAELDRQLRLNESILRTKVIRPETR
>NC_021191.1|WP_015626245.1|9187859_9188405_-|single-stranded-DNA-binding-protein
MAGETTITVVGNLTDDPELRFTPSGAAVAKFRIASTPRTLDRQSGEWKDGEPLFLACNIWRDAAEHVAESLQRGARVIVQGRLRQRSYETREGEKRTVYELEVDEIGPSLRYATAKVQKMSRSGGGGGGFGGGSGGGGGNRQSSGGGGGGSSFDDPWATAAPASGNRSGGGSSSFDDEPPF
>NC_021191.1|WP_007073789.1|9187580_9187820_-|30S-ribosomal-protein-S18
MAKAAALRKPKKKVNPLDKDGITYIDYKDTALLRKFISDRGKIRARRVTGVTSQQQRQIARAVKNAREMALLPYTATAR
>NC_021191.1|WP_015626244.1|9187116_9187566_-|50S-ribosomal-protein-L9
MKIILTHEVSGLGTPGDIVEVKNGYGRNYLLPQGFAIQWSKGAEKQVTVIKRARDAREIRDLGQANEVKGQLEGLKVTLTARSGNGGRLFGSITPAEIVDAVKAAGGPSLDRRRLELPGHIKTTGSYRVQVKLHPEVTASFPVNVVAAK
>NC_021191.1|WP_051167716.1|9183145_9187027_+|hypothetical-protein
MDPLPSWQQPPASPTSSYPQDTPSWQRSADNPPSWQQRPADAAPSWQLPPADATPSRQPPADPTPSWQRPADGAPSWQRSADSTPSWQQSAPPDSPPSWQRPADAAPSWQQYSTPPAAAPTSSWDTSRSDRPSWDTRSSWQPTARSWGDDGRHLVREDDRAQWRRESAAAQGGLDDGSSQGGRRRAPEPGSRTNGGTGWTTRSDADNWAGHADTGSISLPFQDPAADSWRTSSTTSSWQSSAPETESWRSGPRRDEQPDSWRRDPDPAPPIDPWAQSATETGVIPLPLQPRDPGDQGRSWQSRTDTGSWQREPGTGSRSRRSRSDGPREIESGSPSASGSWQRREIESASPSASGSWRRDDDRTDTGSWRRGEERTDTGSRRRGDLSAPGESASWQRSAPPADSGSWQRSAPPEESPSWQRSAPPAGESPSWQRSAPPAPAGEQPSWQRSAPPAPADEQASWQRSAPPAPGETGSWRRATPPAPGDTGSWRSGSPQPGPADTGSWRRDDADTGSRSRSDRLSPSDTGSWQRGDQSSLADRSSLADRSSTVDRSSLADRSSTVDRSSTVDRNSLGDQSRRGDKSRRGERLAPGDTGSWQRGDRPAPGDTGSWERDGEARSGRTVDRRSRQRGPETQREPRRGLDAQRGVGMPARRDGQRDLRGRREPDTSWQRELESAAWDRDHEADVWLRDADTGQWHRAEADDDEDDEDDRGDRPRRRRRAPDDGNGPPAPEGGRAEGRRGRRRAPEAPLELGAAPEPAIDPQAYPRTGDDPARPLTSRARELEAGPSAAQRSAPPAAPRSAPPAAPRSGLPAAPRSGLPAAPRSGLPAGYDRPMSGPPAGYDRPVSGPTGTYDGYDSPISAAPATGGGYGAGDAYTRPMSAPPGGQVDNRPVSGMPTSAPPGTRSDERPGSRSDERPGSRSDERPDSGPEGHPNRQRSAWQQEPRPAWQQELRPGTQEDPRPSWQRELAQPDGAPDGEPPRTPTEEPTTSWLSELGGGRQQLGGTPPVSPSTSFGGRASVDPGQPGGWRADAQATAQAESWRSQMRAEEAGAAPSDAVTEIRQSPEAGGKGSANYREGGSTDWRRELKAESNLSDGESRRFGTSDFVPFRSPAKDPAAAAVPAASSAPAGATEVIPRTGASWQDPPDTEWPPRGAVMTSPTGSYERRPVSTLTSASARQSDLLEPDDEIEEDTGGPLAAVGYTVVWYGVPVVLFVIYMLVLDGGQQTHALDTLAKAAPQFGLSLVLSILVAIGLRWASGSWKAASVGLAAAVMGGGLATVLTSAITGQSLS
>NC_021191.1|WP_015626241.1|9180532_9181948_-|replicative-DNA-helicase
MSVTDDARPEARPQSSGRPSGPPPSADGGFDKTPPQDIAAEQSVLGGMLLSKDAIADVVEILKTPDFYRPVHAKIFDIILDLYGRGEPADGVTVAAALSDSGDLQRIGGVPYLHTLIESVPTAANASYYARIVSERAVLRRLVEAGTKIVQLGYGASGSGGRDVDDIVDLAQQAIYDVTEKRVSEDFAALGDMLQPTLDEIEAVGASGGVMTGVPTGFSDLDRLLNGLHAGQLIIVAGRPGLGKSTVSMDFARNAAIRSNCASAIFSLEMSKIEMVMRLLSAEARVPLHTLRSGQLSDDDWTKLARRMGEISEAPIFVDDTPNMNLMEIRAKARRLKQRHNLKLLVIDYLQLMSSPKKTESRQQEVSELSRGLKLLAKEIECPVIAVSQLNRGPEQRTDKRPQLSDLRESGSIEQDADVVLLLHRDDYYDKESPRAGEADFIVAKHRNGPTDTVTVAAQLHLSRFVDMAIV
>NC_021191.1|WP_157408674.1|9180155_9180509_+|hypothetical-protein
MELMLMMAPAEIAYQAVLTSDGSGTVTSLIAYEAQPTGSLRAVLWSVPRQAWIYAPAQASTFLFDPGYQDRTRPLTRTNAQQVATAVLGTELPDEATLLEMYAEGERMGWSYGPPRQ
>NC_021191.1|WP_015626251.1|9198287_9198758_-|DUF5318-domain-containing-protein
MRTQRQVVDYSLQKRALLRELHNGKIGALEVCDASPYLKNAARFHGEPTVERCPVCRRDNLTLVHYIYGDELKQSAGQARKLAELSLLAMTLREFQVFVVEVCQSCAWNHLIEQYLLGRDALSTDELNQGAAAVAASASGRHRETGSSSHRREGRQ
>NC_021191.1|WP_015626252.1|9198913_9199537_+|PadR-family-transcriptional-regulator
MLEMAILGLLQETSMHGYELRKELATKLGTIRAAISYGTLYPTLKRLHAAGWISEQDADTAIVPPMTSKRGRIVYKITAEGKERFADLLAQAGPETYDDAGFGVHFTFFSRTDRATRLRILEGRRRRIEERREGLRDVLARAGDRLDAYTLELQRHGLDACEREVRWLEELITNERSGRTPGNGPSSTADPAAEAPPEPPAPHQDRP
>NC_021191.1|WP_041834568.1|9199557_9200637_+|inositol-3-phosphate-synthase
MGSVRVAIVGVGNCASSLVQGVEYYRNADPNDRVPGLMHVTFGDYHVSDVKFVAAFDVDAKKVGMDLADAINASENNTIKLTDVPPTGVSVQRGPTFDGLGTYYREIIEESSAEVVDVVQALREAEVDVVVSYLPVGSEEADKFYAQAAIDAGCAFVNALPVFIASDPTWAKKFEDAGLPIVGDDIKSQVGATIVHRALAKLFEDRGVELLRTYQLNFGGNMDFMNMLERKRLVSKKISKTQSVTSQIPHEMIKSDVHIGPSDHVPWLDDRKWAYIRLEGRSFGDTPLNAELKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPILSASSYFMKSPPVQYNDHDAKASVEAFIKGEIER
>NC_021191.1|WP_041833029.1|9200673_9201141_-|methylated-DNA--[protein]-cysteine-S-methyltransferase
MRLVVESPIGPLGVELDGETVVGVRFAASGPVSASDLPIARELAGYFGGTLTDFTVPVELRGGSEFERAVWGQIATVPYGTMRTYGEVAKALGDPGAARAVGTACNRNPVPVLIPCHRVVGAGGKMVGFGGGLPRKRLLLELEARVTLAQMWEMS
>NC_021191.1|WP_041833030.1|9201145_9202576_-|CCA-tRNA-nucleotidyltransferase
MSVLNSAQRNAVQELLRVSPVADELGRRFGAAGHELHLVGGSVRDALLGTLGDDLDFCTDARPEQTLALVKGWADAIWETGREFGTIGVQKNGLRLEITTYRAESYDGVTRNPTVEYGDNLLDDLRRRDFTINAMAVSLPGHVFTDPYGGLEDLAAKVIKTPSRPEESFGDDPLRMLRAARFAAKLRFTVDPVTLAAIKTMAADLDRITAERIRDEFTKLLCGADPVAGLRLLVDTGLADRFLPELSGLKLEIDEHAQHKDVYEHTLIVVTNAVRLEGDSGPDFTLRMAALMHDIGKPATKAVGRDGRVSFHHHEVVGARLTKQRMKALKYPKDITTDVVQLVALHLRFYGYGRGEWTDSAVRRYVTDAGELLSRLHKLTRSDCTTRNRRKAAALAADYDALEDRITRIQAEEDLARVRPDLDGNAIMELLGVPPGPIVGQAWRYLKELRLDRGPLPRDEAEVELLRWAREQGHIS
>NC_021191.1|WP_051167717.1|9202574_9203525_+|hypothetical-protein
MGSPGYRSWRSPDAAGRIGAVPVPEALRRLSEDPEFWSLLRAEDGAFPDPETAELRVSFPVTGGYGLVLEIDLATGEQTLGLREPATSEPVPLGRFAAGHPFPAALRWHELELCARVIALEDPTLPHPGLVIALLAPFAPVTEDDDGSTVAAVREAAYRSLRREVPPPAPSGPEQTPLPLFAGDDWWPRPPQPSPQVLDEAAVAAYSSAAYAQLQVRAAARFPRDGLADLVRKAARRLSRVPEEQGYDQGRPLARQITATGDLRTVNALLGVLTEAGCDHPTVLDALSEPLVPLEACWMVETLAGAAPGTLLRRHV
>NC_021191.1|WP_015626257.1|9203576_9205394_+|murein-biosynthesis-integral-membrane-protein-MurJ
MSGGIYRSANAAPGEPDRPADSTFLLSVDSTATMPTPAADQPLPPEVIPATSGGTVYGSPAAGPEPEAEPAKRSALGNSAIMAAGSLVSRVIGFVRNMLIGMTLGKAIGDPYTSATFLPNQIYELLLGGVLSSVLIPLLVRRRKSDPDGGQLFTQRLLTLAVVSLGLAALLVTVLAPAITAIQSSSDAVPGYQGLVTSLSYWILPMIFFTGLSALIGAVLNVRGHFAAPMWAPILNNLVIIAACGAFILFYGTASGLRPGDMSPGEIALIGGGTLLGMVVQGIGLLPALKQVGFSWSWQWNPRALGLGEVGGLAGWMLLWVGANQIAVFVVARVLSGIGGDKDASLLAFNQVFLLTMMAHGIVGVSVMTALLPNMSAAADEGRFADVSADLTRGIRLTATALAPVCVIYGVLGVPIAVTLFQGGALSYDQAFAIGGVLVVAAFAVIPLSISYLCNYAFYALQGNKTVALINLPVVAVRIGGYFVVVELLSKSLAAAGMTAANAVSYLLSAVISLALLRRRIGRLNLGTVGRALVKVVVAAAIAAVAGVLVVKLLPGGDTPGRPAALMQVVIGGGVILVAYLVAATLLKVQEVSQVVGMVRRKLGR
>NC_021191.1|WP_015626258.1|9205570_9207121_+|protein-kinase
MTQVGEGHETTADGAGPVMTFGAPTVGEILAERYQLEEHVNNDSAGRQVWRGIDVILRRPVAVVLRHPGGASAAEMLQAAVDASRVIHPNLVGVYDAIDEGQRAYVVREWVDGESLRELVAQEGPLDPRRATAIAHALADALAAVHATGMVHGNVHPGTTLIGDDGRVVLADARADSADSTEMDVRSVGGILYFSLTGHWPHAEIAPSTLPDATRDGSGAVTTPRQVRAGIPAYLDDLTMDLLDKRVAAPEAEALSAELGRLDSSADDDYEDVGPLRFTQGTAAEPVRSTRKIVIGIAALAVIAVLGLVFGIRAISDSGGDKPANTTEANSAPQNNGNGSTSGSDANSGGATTGEPKKIPLTASMVRIVDPPDGDRQDGPEAKYVVDDDKDTVWRTQGFKQAKFYNKPGMGLLINLGSPRSVSDVRVETTSTGVGMDIRTGTSDPGDSPSGDARVAKDFKKLGDGDTEKTDGTNSVFNVFDPQQKYQYILVWVTELPRDNDGSYRLEMSKVEVYGN
>NC_021191.1|WP_015626259.1|9207172_9207865_+|RNA-polymerase-sigma-factor-SigM
MTTGGNRDGTDLPGPTDAELLRAHVEGDPQAFGELVRRHRDRLWAVALRTIGDREEAADAVQDALLSAHRAAARFRGDAAVTTWLHRIVVNSCLDRIRRRQAHPTVPLPDGTHTDEGGSGTGPEPAAPARDHDTALVVRAALADLPPDQRAALVLVDIEGYAVVEAAEILGVAEGTIKSRCARGRARLALALRDLKNGTEPGNPGRTGRVPSGSGTTGPVPGRGDRGDRA
>NC_021191.1|WP_015626260.1|9207861_9208713_+|hypothetical-protein
MTGAEFSGVDIDLLADFVGGALDGTPDEARVARRIAEDPAWQDAFVELSAGVEAVAGALRSWGTEPEPMPDDVVARLDAALLAPPAPETPQLVAVPGGKPSSSRRRRLTWAVPIGVAAAAVAFAGVGLRQWNSDSPVKSDSAAGGSTVTTLAAPPAQQLESGIDYTRQSLGQAAASTLLGSAPPARINGQDQAGEGATAKAAPGDALARLRVPEALVACLTAIAGQNGVGQVAAQTVDYARFQGAPALIVHFTAANGTWVWAVGAACGLPGSGTDMLASVRVG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_021191_17	17.1\|7260368\|19\|NC_021191\|CRISPRCasFinder	7260368-7260386	19	NC_021191.1	2996657-2996675	2	0.895

1. spacer 17.1|7260368|19|NC_021191|CRISPRCasFinder matches to position: 2996657-2996675, mismatch: 2, identity: 0.895

gtctccaggacaccgaccg	CRISPR spacer
gtccccaggacaccgatcg	Protospacer
***.************.**

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021191_18	18.1\|7268052\|23\|NC_021191\|CRT	7268052-7268074	23	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	4775487-4775509	1	0.957
NC_021191_12	12.2\|4737204\|23\|NC_021191\|PILER-CR	4737204-4737226	23	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	606832-606854	2	0.913
NC_021191_18	18.1\|7268052\|23\|NC_021191\|CRT	7268052-7268074	23	NZ_CP050953	Rhodococcus sp. DMU1 plasmid unnamed	377679-377701	2	0.913
NC_021191_18	18.1\|7268052\|23\|NC_021191\|CRT	7268052-7268074	23	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	1694825-1694847	2	0.913
NC_021191_18	18.1\|7268052\|23\|NC_021191\|CRT	7268052-7268074	23	NC_048046	Caulobacter phage CcrPW, complete genome	55691-55713	2	0.913
NC_021191_5	5.3\|1943760\|26\|NC_021191\|CRISPRCasFinder	1943760-1943785	26	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	1912177-1912202	3	0.885
NC_021191_12	12.2\|4737204\|23\|NC_021191\|PILER-CR	4737204-4737226	23	NZ_CP038636	Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence	67590-67612	3	0.87
NC_021191_18	18.1\|7268052\|23\|NC_021191\|CRT	7268052-7268074	23	NZ_CP038636	Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence	317737-317759	3	0.87
NC_021191_18	18.2\|7268114\|22\|NC_021191\|CRT	7268114-7268135	22	NZ_CP045074	Paracoccus kondratievae strain BJQ0001 plasmid unnamed1, complete sequence	89003-89024	3	0.864
NC_021191_18	18.3\|7268175\|22\|NC_021191\|CRT	7268175-7268196	22	NZ_CP045074	Paracoccus kondratievae strain BJQ0001 plasmid unnamed1, complete sequence	89003-89024	3	0.864
NC_021191_2	2.1\|315641\|27\|NC_021191\|CRISPRCasFinder	315641-315667	27	NZ_CP040819	Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence	162422-162448	4	0.852
NC_021191_5	5.3\|1943760\|26\|NC_021191\|CRISPRCasFinder	1943760-1943785	26	NC_015685	Oligotropha carboxidovorans OM5 plasmid pOC167, complete sequence	60677-60702	4	0.846
NC_021191_18	18.1\|7268052\|23\|NC_021191\|CRT	7268052-7268074	23	NZ_CP017563	Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence	99160-99182	4	0.826
NC_021191_2	2.1\|315641\|27\|NC_021191\|CRISPRCasFinder	315641-315667	27	NZ_CP017105	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence	790820-790846	5	0.815
NC_021191_5	5.3\|1943760\|26\|NC_021191\|CRISPRCasFinder	1943760-1943785	26	NZ_CP013104	Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence	1351818-1351843	5	0.808
NC_021191_19	19.2\|7625286\|30\|NC_021191\|CRT	7625286-7625315	30	MH067972	Arthrobacter sp. strain ANT_H44B plasmid pA44BH1, complete sequence	30092-30121	5	0.833
NC_021191_19	19.2\|7625286\|30\|NC_021191\|CRT	7625286-7625315	30	MH067973	Arthrobacter sp. strain ANT_H48B plasmid pA48BH1, complete sequence	30080-30109	5	0.833
NC_021191_19	19.2\|7625286\|30\|NC_021191\|CRT	7625286-7625315	30	NC_048112	Escherichia phage Skarpretter, complete genome	31988-32017	5	0.833
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP046573	Rhodococcus sp. WAY2 plasmid pRWAY01, complete sequence	358141-358166	5	0.808
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP024314	Rhizobium sp. NXC24 plasmid pRspNXC24c, complete sequence	1770943-1770968	5	0.808
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	KY006853	Erythrobacter phage vB_EliS_R6L, complete genome	59019-59044	5	0.808
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NC_019957	Mycobacterium sp. JS623 plasmid pMYCSM01, complete sequence	255246-255274	5	0.828
NC_021191_2	2.1\|315641\|27\|NC_021191\|CRISPRCasFinder	315641-315667	27	MN536026	Pseudomonas phage vB_Pae-SS2019XI, complete genome	47023-47049	6	0.778
NC_021191_3	3.1\|499354\|33\|NC_021191\|CRISPRCasFinder	499354-499386	33	NZ_CP019316	Tateyamaria omphalii strain DOK1-4 plasmid pDOK1-4-4, complete sequence	30568-30600	6	0.818
NC_021191_5	5.3\|1943760\|26\|NC_021191\|CRISPRCasFinder	1943760-1943785	26	NZ_CP012748	Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence	1963015-1963040	6	0.769
NC_021191_8	8.1\|3746090\|27\|NC_021191\|CRISPRCasFinder	3746090-3746116	27	NZ_CP023549	Rhodobacter sp. CZR27 plasmid unnamed1, complete sequence	264407-264433	6	0.778
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP007795	Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence	650553-650583	6	0.806
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP032323	Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence	445830-445860	6	0.806
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP032325	Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence	172212-172242	6	0.806
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP022369	Azospirillum sp. TSH58 plasmid TSH58_p05, complete sequence	348666-348696	6	0.806
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP007796	Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence	521504-521534	6	0.806
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NC_024957	Methylibium sp. T29 plasmid pT29A, complete sequence	6754-6784	6	0.806
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NC_024958	Methylibium sp. T29-B plasmid pT29B, complete sequence	6754-6784	6	0.806
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP042515	Serratia marcescens strain E28 plasmid pE28_003	8008-8038	6	0.806
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NC_013856	Azospirillum sp. B510 plasmid pAB510b, complete sequence	534078-534108	6	0.806
NC_021191_19	19.2\|7625286\|30\|NC_021191\|CRT	7625286-7625315	30	NZ_CP049157	Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence	988269-988298	6	0.8
NC_021191_19	19.2\|7625286\|30\|NC_021191\|CRT	7625286-7625315	30	NZ_CP049317	Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence	656144-656173	6	0.8
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP044330	Methylocystis rosea strain BRCS1 plasmid unnamed2, complete sequence	185884-185909	6	0.769
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP034088	Methylocystis rosea strain GW6 plasmid pGW6_2, complete sequence	207433-207458	6	0.769
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NZ_CP033508	Mesorhizobium jarvisii strain ATCC 700743 plasmid pMJ700743a, complete sequence	141655-141683	6	0.793
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NZ_CP033369	Mesorhizobium loti strain SU343 plasmid pMLSU343a, complete sequence	141655-141683	6	0.793
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NZ_CP016080	Mesorhizobium loti NZP2037 plasmid pML2037, complete sequence	370178-370206	6	0.793
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	MK977696	Gordonia phage SCentae, complete genome	19023-19051	6	0.793
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	MK977695	Gordonia phage Pupper, complete genome	19006-19034	6	0.793
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	1383479-1383507	6	0.793
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	748894-748922	6	0.793
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	309540-309570	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP029452	Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence	429536-429566	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP023071	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666b, complete sequence	331128-331158	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	1618647-1618677	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NC_010848	Flavobacterium sp. KI723T1 plasmid pOAD2 DNA, complete sequence	13363-13393	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KX388535	Agrobacterium tumefaciens strain EU6 plasmid pTiEU6, complete sequence	118578-118608	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KY000059	Agrobacterium tumefaciens strain CFBP1898 plasmid pTi_CFBP1898, complete sequence	128720-128750	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP042277	Agrobacterium tumefaciens strain 186 plasmid pTi, complete sequence	66250-66280	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP039927	Agrobacterium tumefaciens strain CFBP7129 plasmid pTiCFBP7129, complete sequence	75461-75491	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP032925	Agrobacterium tumefaciens strain 1D1108 plasmid pTi1D1108, complete sequence	64886-64916	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP033026	Agrobacterium fabrum strain 1D132 plasmid pTi1D132, complete sequence	65890-65920	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KY000039	Agrobacterium deltaense strain Tun180 plasmid pTi_Tun180, complete sequence	134522-134552	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KY000064	Agrobacterium tumefaciens strain CFBP7126 plasmid pTi_CFBP7126, complete sequence	72963-72993	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KY000058	Agrobacterium rhizogenes strain CFBP1317 plasmid pTi_CFBP1317, complete sequence	127586-127616	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KY000068	Agrobacterium deltaense strain Tun151 plasmid pTi_Tun151, complete sequence	126636-126666	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KY000070	Agrobacterium tumefaciens strain Tun178 plasmid pTi_Tun178, complete sequence	42787-42817	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KY000066	Agrobacterium deltaense strain CFBP7129 plasmid pTi_CFBP7129, complete sequence	84101-84131	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KY000062	Agrobacterium genomosp. 3 strain CFBP4424 plasmid pTi_CFBP4424, complete sequence	177211-177241	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KY000071	Agrobacterium tumefaciens strain Tun183 plasmid pTi_Tun183, complete sequence	31471-31501	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_KY000063	Agrobacterium fabrum strain CFBP6549 plasmid pTi_CFBP6549, complete sequence	65775-65805	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NC_009472	Acidiphilium cryptum JF-5 plasmid pACRY06, complete sequence	4560-4590	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NC_009472	Acidiphilium cryptum JF-5 plasmid pACRY06, complete sequence	4600-4630	7	0.774
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NC_009472	Acidiphilium cryptum JF-5 plasmid pACRY06, complete sequence	4640-4670	7	0.774
NC_021191_19	19.2\|7625286\|30\|NC_021191\|CRT	7625286-7625315	30	MF403007	Agrobacterium phage Atu_ph04, complete genome	5247-5276	7	0.767
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP050092	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence	788876-788901	7	0.731
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP050098	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b4, complete sequence	866868-866893	7	0.731
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP018229	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence	1208727-1208752	7	0.731
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP016287	Rhizobium leguminosarum strain Vaf10 plasmid unnamed1, complete sequence	610720-610745	7	0.731
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP054022	Rhizobium sp. JKLM12A2 plasmid pPR12A201, complete sequence	420482-420507	7	0.731
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	494077-494102	7	0.731
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP054032	Rhizobium sp. JKLM13E plasmid pPR13E01, complete sequence	153665-153690	7	0.731
NC_021191_19	19.3\|7625340\|26\|NC_021191\|CRT	7625340-7625365	26	NZ_CP022565	Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK01, complete sequence	729485-729510	7	0.731
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NZ_CP033228	Sphingobium yanoikuyae strain SJTF8 plasmid pF2, complete sequence	89764-89792	7	0.759
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NC_019408	Caulobacter phage CcrRogue, complete genome	19728-19756	7	0.759
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NZ_CP019603	Croceicoccus marinus strain E4A9 plasmid pCME4A9I, complete sequence	397417-397445	7	0.759
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	779603-779633	8	0.742
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1055467-1055497	8	0.742
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	77528-77558	8	0.742
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP021031	Rhizobium sp. NXC14 plasmid pRspNXC14a, complete sequence	73879-73909	8	0.742
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	714121-714151	8	0.742
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	MN234228	Mycobacterium phage Tourach, complete genome	39916-39946	8	0.742
NC_021191_19	19.2\|7625286\|30\|NC_021191\|CRT	7625286-7625315	30	NZ_CP015094	Pelagibaca abyssi strain JLT2014 plasmid pPABY6, complete sequence	59146-59175	8	0.733
NC_021191_19	19.2\|7625286\|30\|NC_021191\|CRT	7625286-7625315	30	NZ_CP025431	Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence	50577-50606	8	0.733
NC_021191_19	19.2\|7625286\|30\|NC_021191\|CRT	7625286-7625315	30	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	356251-356280	8	0.733
NC_021191_19	19.2\|7625286\|30\|NC_021191\|CRT	7625286-7625315	30	NZ_CP044989	Deinococcus sp. AJ005 plasmid p380k, complete sequence	34040-34069	8	0.733
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NZ_CP030263	Ensifer adhaerens strain Corn53 plasmid AA, complete sequence	466733-466761	8	0.724
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	MF695815	Klebsiella phage KPP5665-2, complete genome	13476-13504	8	0.724
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	MK416008	Klebsiella phage ST405-OXA48phi1.3, complete genome	27843-27871	8	0.724
NC_021191_19	19.6\|7625512\|29\|NC_021191\|CRT	7625512-7625540	29	NZ_CP027613	Klebsiella pneumoniae subsp. ozaenae strain AR_0096 plasmid unnamed1, complete sequence	59950-59978	8	0.724
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP014310	Burkholderia sp. PAMC 26561 plasmid unnamed3, complete sequence	405128-405158	9	0.71
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	465227-465257	9	0.71
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP015881	Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence	548227-548257	9	0.71
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP032324	Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence	19263-19293	9	0.71
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NZ_CP007515	Rubrobacter radiotolerans strain RSPS-4 plasmid 1, complete sequence	47144-47174	9	0.71
NC_021191_10	10.1\|4427604\|31\|NC_021191\|CRISPRCasFinder	4427604-4427634	31	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	685168-685198	10	0.677

1. spacer 18.1|7268052|23|NC_021191|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 1, identity: 0.957

ccaccgccgccgcccgaggcagc	CRISPR spacer
ccaccgccgccgcccgaggccgc	Protospacer
******************** **

2. spacer 12.2|4737204|23|NC_021191|PILER-CR matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 2, identity: 0.913

gtccgccgcgctcctgcctggtc	CRISPR spacer
gtccgccgcgctccttcccggtc	Protospacer
*************** **.****

3. spacer 18.1|7268052|23|NC_021191|CRT matches to NZ_CP050953 (Rhodococcus sp. DMU1 plasmid unnamed) position: , mismatch: 2, identity: 0.913

ccaccgccgccgcccgaggcagc	CRISPR spacer
ccacccccgccccccgaggcagc	Protospacer
***** ***** ***********

4. spacer 18.1|7268052|23|NC_021191|CRT matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.913

ccaccgccgccgcccgaggcagc	CRISPR spacer
ccaccgccgccgccgcaggcagc	Protospacer
**************  *******

5. spacer 18.1|7268052|23|NC_021191|CRT matches to NC_048046 (Caulobacter phage CcrPW, complete genome) position: , mismatch: 2, identity: 0.913

ccaccgccgccgcccgaggcagc	CRISPR spacer
ccgccgccgccgcccgaggcaac	Protospacer
**.******************.*

6. spacer 5.3|1943760|26|NC_021191|CRISPRCasFinder matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 3, identity: 0.885

ggatcgagggccgctccggaatcgac	CRISPR spacer
tgatcgatggccgctccggaatcggc	Protospacer
 ****** ****************.*

7. spacer 12.2|4737204|23|NC_021191|PILER-CR matches to NZ_CP038636 (Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.87

gtccgccgcgctcctgcctggtc	CRISPR spacer
gaccgccgcgctcctgcctggct	Protospacer
* *******************..

8. spacer 18.1|7268052|23|NC_021191|CRT matches to NZ_CP038636 (Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.87

ccaccgccgccgcccgaggcagc	CRISPR spacer
gtaccgccgccgcccgaagcagc	Protospacer
 .***************.*****

9. spacer 18.2|7268114|22|NC_021191|CRT matches to NZ_CP045074 (Paracoccus kondratievae strain BJQ0001 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.864

gcaacgcggccagccaacgctg	CRISPR spacer
tcaacgcggccagccaacgcga	Protospacer
 ******************* .

10. spacer 18.3|7268175|22|NC_021191|CRT matches to NZ_CP045074 (Paracoccus kondratievae strain BJQ0001 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.864

gcaacgcggccagccaacgctg	CRISPR spacer
tcaacgcggccagccaacgcga	Protospacer
 ******************* .

11. spacer 2.1|315641|27|NC_021191|CRISPRCasFinder matches to NZ_CP040819 (Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence) position: , mismatch: 4, identity: 0.852

tcggagagctggtggtagagcgccatc	CRISPR spacer
ccggcgagctgggggtagagcgccacc	Protospacer
.*** ******* ************.*

12. spacer 5.3|1943760|26|NC_021191|CRISPRCasFinder matches to NC_015685 (Oligotropha carboxidovorans OM5 plasmid pOC167, complete sequence) position: , mismatch: 4, identity: 0.846

ggatcgagggccgctccggaatcgac	CRISPR spacer
gtggcgagggccgctccggaattgac	Protospacer
* . ******************.***

13. spacer 18.1|7268052|23|NC_021191|CRT matches to NZ_CP017563 (Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence) position: , mismatch: 4, identity: 0.826

ccaccgccgccgcccgaggcagc	CRISPR spacer
ccaccgccgccgcccgaggtgaa	Protospacer
*******************...

14. spacer 2.1|315641|27|NC_021191|CRISPRCasFinder matches to NZ_CP017105 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence) position: , mismatch: 5, identity: 0.815

tcggagagctggtggtagagcgccatc	CRISPR spacer
acggggagctggtggtagagcgggata	Protospacer
 ***.*****************  **

15. spacer 5.3|1943760|26|NC_021191|CRISPRCasFinder matches to NZ_CP013104 (Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence) position: , mismatch: 5, identity: 0.808

ggatcgagggccgctccggaatcgac	CRISPR spacer
ggatcgagggccgctccggcgcggtc	Protospacer
******************* .. * *

16. spacer 19.2|7625286|30|NC_021191|CRT matches to MH067972 (Arthrobacter sp. strain ANT_H44B plasmid pA44BH1, complete sequence) position: , mismatch: 5, identity: 0.833

cgagacaaaccagccagccagccgcgccag	CRISPR spacer
ttggacaagccagccagccagccgccccag	Protospacer
. .*****.**************** ****

17. spacer 19.2|7625286|30|NC_021191|CRT matches to MH067973 (Arthrobacter sp. strain ANT_H48B plasmid pA48BH1, complete sequence) position: , mismatch: 5, identity: 0.833

cgagacaaaccagccagccagccgcgccag	CRISPR spacer
ttggacaagccagccagccagccgccccag	Protospacer
. .*****.**************** ****

18. spacer 19.2|7625286|30|NC_021191|CRT matches to NC_048112 (Escherichia phage Skarpretter, complete genome) position: , mismatch: 5, identity: 0.833

cgagacaaaccagccagccagccgcgccag	CRISPR spacer
caaagaataccagccagccagccgcgccag	Protospacer
*.*.. * **********************

19. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP046573 (Rhodococcus sp. WAY2 plasmid pRWAY01, complete sequence) position: , mismatch: 5, identity: 0.808

gagaccagcccggccgcccgcactgg	CRISPR spacer
cggacctgctcggccgcccgcactgc	Protospacer
 .**** **.***************

20. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP024314 (Rhizobium sp. NXC24 plasmid pRspNXC24c, complete sequence) position: , mismatch: 5, identity: 0.808

gagaccagcccggccgcccgcactgg	CRISPR spacer
gagacaagcccggtcgcccgcacgat	Protospacer
***** *******.********* .

21. spacer 19.3|7625340|26|NC_021191|CRT matches to KY006853 (Erythrobacter phage vB_EliS_R6L, complete genome) position: , mismatch: 5, identity: 0.808

gagaccagcccggccgcccgcactgg	CRISPR spacer
cagaccagcccggccgccagcagccg	Protospacer
 ***************** *** . *

22. spacer 19.6|7625512|29|NC_021191|CRT matches to NC_019957 (Mycobacterium sp. JS623 plasmid pMYCSM01, complete sequence) position: , mismatch: 5, identity: 0.828

gaggcgaaccagccgggcggcagcgctgg-	CRISPR spacer
gaggcgaaccaggcgggcggcag-gtagac	Protospacer
************ ********** *. *.

23. spacer 2.1|315641|27|NC_021191|CRISPRCasFinder matches to MN536026 (Pseudomonas phage vB_Pae-SS2019XI, complete genome) position: , mismatch: 6, identity: 0.778

tcggagagctggtggtagagcgccatc	CRISPR spacer
ccatcgtactggtggtagagcgccatc	Protospacer
.*.  * .*******************

24. spacer 3.1|499354|33|NC_021191|CRISPRCasFinder matches to NZ_CP019316 (Tateyamaria omphalii strain DOK1-4 plasmid pDOK1-4-4, complete sequence) position: , mismatch: 6, identity: 0.818

aggcggcagcctcgggccttcccgctccgcgat	CRISPR spacer
agtaggtcgcctcgggccgtcccgcgccgcgat	Protospacer
**  **. ********** ****** *******

25. spacer 5.3|1943760|26|NC_021191|CRISPRCasFinder matches to NZ_CP012748 (Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.769

ggatcgagggccgctccggaatcgac	CRISPR spacer
ggatcgagggccgctccggcgcgggt	Protospacer
******************* .. *..

26. spacer 8.1|3746090|27|NC_021191|CRISPRCasFinder matches to NZ_CP023549 (Rhodobacter sp. CZR27 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

tcggttctcgctcccggactcatcgca	CRISPR spacer
caggttcttgctgccggactcatcgtc	Protospacer
. ******.*** ************.

27. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP007795 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence) position: , mismatch: 6, identity: 0.806

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
gcggggccgccacgccgctcgccggcagcgc	Protospacer
**.******** **************. *.

28. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP032323 (Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence) position: , mismatch: 6, identity: 0.806

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
gcggggccgccacgccgctcgccggcagcgc	Protospacer
**.******** **************. *.

29. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP032325 (Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence) position: , mismatch: 6, identity: 0.806

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
gcttgttcgcctcgccgcccgccgtcgccag	Protospacer
**  * .***********.***** ******

30. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP022369 (Azospirillum sp. TSH58 plasmid TSH58_p05, complete sequence) position: , mismatch: 6, identity: 0.806

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
gcttgttcgcctcgccgcccgccgtcgccag	Protospacer
**  * .***********.***** ******

31. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP007796 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence) position: , mismatch: 6, identity: 0.806

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
gcttgttcgcctcgccgcccgccgtcgccag	Protospacer
**  * .***********.***** ******

32. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NC_024957 (Methylibium sp. T29 plasmid pT29A, complete sequence) position: , mismatch: 6, identity: 0.806

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
gcagggccgccttgccgatcgccgcctcgat	Protospacer
************.**** ****** * * *

33. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NC_024958 (Methylibium sp. T29-B plasmid pT29B, complete sequence) position: , mismatch: 6, identity: 0.806

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
gcagggccgccttgccgatcgccgcctcgat	Protospacer
************.**** ****** * * *

34. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP042515 (Serratia marcescens strain E28 plasmid pE28_003) position: , mismatch: 6, identity: 0.806

gcag-ggccgcctcgccgctcgccggcgccag	CRISPR spacer
-cagccgccccctcgccgcacgccggcgcagg	Protospacer
 ***  *** ********* ********* .*

35. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NC_013856 (Azospirillum sp. B510 plasmid pAB510b, complete sequence) position: , mismatch: 6, identity: 0.806

gcagggccgcctcgccgctcgccggcgccag-	CRISPR spacer
gcaagcccgcctcgccgctcgcc-tcgccttc	Protospacer
***.* *****************  ****

36. spacer 19.2|7625286|30|NC_021191|CRT matches to NZ_CP049157 (Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence) position: , mismatch: 6, identity: 0.8

cgagacaaaccagccagccagccgcgccag	CRISPR spacer
cgacacaaacccgccagccagcccggtcat	Protospacer
*** ******* ***********  *.**

37. spacer 19.2|7625286|30|NC_021191|CRT matches to NZ_CP049317 (Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence) position: , mismatch: 6, identity: 0.8

cgagacaaaccagccagccagccgcgccag	CRISPR spacer
cgacacaaacccgccagccagcccggtcat	Protospacer
*** ******* ***********  *.**

38. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP044330 (Methylocystis rosea strain BRCS1 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.769

gagaccagcccggccgcccgcactgg	CRISPR spacer
gagaccagcccggccggccgcctgca	Protospacer
**************** **** .  .

39. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP034088 (Methylocystis rosea strain GW6 plasmid pGW6_2, complete sequence) position: , mismatch: 6, identity: 0.769

gagaccagcccggccgcccgcactgg	CRISPR spacer
gagaccagcccggccggccgcctgca	Protospacer
**************** **** .  .

40. spacer 19.6|7625512|29|NC_021191|CRT matches to NZ_CP033508 (Mesorhizobium jarvisii strain ATCC 700743 plasmid pMJ700743a, complete sequence) position: , mismatch: 6, identity: 0.793

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
gaggcgagccagccggccggcagcggatc	Protospacer
*******.******** ********

41. spacer 19.6|7625512|29|NC_021191|CRT matches to NZ_CP033369 (Mesorhizobium loti strain SU343 plasmid pMLSU343a, complete sequence) position: , mismatch: 6, identity: 0.793

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
gaggcgagccagccggccggcagcggatc	Protospacer
*******.******** ********

42. spacer 19.6|7625512|29|NC_021191|CRT matches to NZ_CP016080 (Mesorhizobium loti NZP2037 plasmid pML2037, complete sequence) position: , mismatch: 6, identity: 0.793

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
gaggcgagccagccggccggcagcggatc	Protospacer
*******.******** ********

43. spacer 19.6|7625512|29|NC_021191|CRT matches to MK977696 (Gordonia phage SCentae, complete genome) position: , mismatch: 6, identity: 0.793

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
gtgacgaaccagccggtcggcagcgcctt	Protospacer
* *.************ *********.

44. spacer 19.6|7625512|29|NC_021191|CRT matches to MK977695 (Gordonia phage Pupper, complete genome) position: , mismatch: 6, identity: 0.793

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
gtgacgaaccagccggtcggcagcgcctt	Protospacer
* *.************ *********.

45. spacer 19.6|7625512|29|NC_021191|CRT matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.793

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
gtgtcgagccagccgggccgcagcgcttc	Protospacer
* * ***.********** ********

46. spacer 19.6|7625512|29|NC_021191|CRT matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 6, identity: 0.793

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
gtgtcgagccagccgggccgcagcgcttc	Protospacer
* * ***.********** ********

47. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
ccgaggccgccgcgctgctcgccggcgccgc	Protospacer
 *..******* ***.*************.

48. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP029452 (Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
ccgaggccgccgcgctgctcgccggcgccgc	Protospacer
 *..******* ***.*************.

49. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP023071 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666b, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
ccgaggccgccgcgctgctcgccggcgccgc	Protospacer
 *..******* ***.*************.

50. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
ccgaggccgccgcgctgctcgccggcgccgc	Protospacer
 *..******* ***.*************.

51. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NC_010848 (Flavobacterium sp. KI723T1 plasmid pOAD2 DNA, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
gcttgcccgcctcgccgctcgacagcgcctt	Protospacer
**  * *************** *.*****

52. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KX388535 (Agrobacterium tumefaciens strain EU6 plasmid pTiEU6, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

53. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KY000059 (Agrobacterium tumefaciens strain CFBP1898 plasmid pTi_CFBP1898, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

54. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP042277 (Agrobacterium tumefaciens strain 186 plasmid pTi, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

55. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP039927 (Agrobacterium tumefaciens strain CFBP7129 plasmid pTiCFBP7129, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

56. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP032925 (Agrobacterium tumefaciens strain 1D1108 plasmid pTi1D1108, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

57. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP033026 (Agrobacterium fabrum strain 1D132 plasmid pTi1D132, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

58. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KY000039 (Agrobacterium deltaense strain Tun180 plasmid pTi_Tun180, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

59. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KY000064 (Agrobacterium tumefaciens strain CFBP7126 plasmid pTi_CFBP7126, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

60. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KY000058 (Agrobacterium rhizogenes strain CFBP1317 plasmid pTi_CFBP1317, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

61. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KY000068 (Agrobacterium deltaense strain Tun151 plasmid pTi_Tun151, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

62. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KY000070 (Agrobacterium tumefaciens strain Tun178 plasmid pTi_Tun178, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

63. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KY000066 (Agrobacterium deltaense strain CFBP7129 plasmid pTi_CFBP7129, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

64. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KY000062 (Agrobacterium genomosp. 3 strain CFBP4424 plasmid pTi_CFBP4424, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

65. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KY000071 (Agrobacterium tumefaciens strain Tun183 plasmid pTi_Tun183, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

66. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_KY000063 (Agrobacterium fabrum strain CFBP6549 plasmid pTi_CFBP6549, complete sequence) position: , mismatch: 7, identity: 0.774

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accgagccgcttcgccgttcgccggcgctcg	Protospacer
.* *.*****.******.**********. *

67. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NC_009472 (Acidiphilium cryptum JF-5 plasmid pACRY06, complete sequence) position: , mismatch: 7, identity: 0.774

gcag-ggccgcctcgccgctcgccggcgccag	CRISPR spacer
-cagccgcctccccgccgctcgccggcgcgcc	Protospacer
 ***  *** **.****************

68. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NC_009472 (Acidiphilium cryptum JF-5 plasmid pACRY06, complete sequence) position: , mismatch: 7, identity: 0.774

gcag-ggccgcctcgccgctcgccggcgccag	CRISPR spacer
-cagccgcctccccgccgctcgccggcgcgcc	Protospacer
 ***  *** **.****************

69. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NC_009472 (Acidiphilium cryptum JF-5 plasmid pACRY06, complete sequence) position: , mismatch: 7, identity: 0.774

gcag-ggccgcctcgccgctcgccggcgccag	CRISPR spacer
-cagccgcctccccgccgctcgccggcgcgcc	Protospacer
 ***  *** **.****************

70. spacer 19.2|7625286|30|NC_021191|CRT matches to MF403007 (Agrobacterium phage Atu_ph04, complete genome) position: , mismatch: 7, identity: 0.767

cgagacaaaccagccagccag---ccgcgccag	CRISPR spacer
cgaggcaaaccagccagccaggattcgtga---	Protospacer
****.****************   .**.*

71. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP050092 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence) position: , mismatch: 7, identity: 0.731

gagaccagcccggccgcccgcactgg	CRISPR spacer
tcgaccagcccggccgcccgcgtgtc	Protospacer
  *******************..

72. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP050098 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b4, complete sequence) position: , mismatch: 7, identity: 0.731

gagaccagcccggccgcccgcactgg	CRISPR spacer
tcgaccagcccggccgcccgcgtgtc	Protospacer
  *******************..

73. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP018229 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.731

gagaccagcccggccgcccgcactgg	CRISPR spacer
tcgaccagcccggccgcccgcgtgtc	Protospacer
  *******************..

74. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP016287 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.731

gagaccagcccggccgcccgcactgg	CRISPR spacer
tcgaccagcccggccgcccgcgtgtc	Protospacer
  *******************..

75. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP054022 (Rhizobium sp. JKLM12A2 plasmid pPR12A201, complete sequence) position: , mismatch: 7, identity: 0.731

gagaccagcccggccgcccgcactgg	CRISPR spacer
tcgaccagcccggccgcccgcgtgtc	Protospacer
  *******************..

76. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 7, identity: 0.731

gagaccagcccggccgcccgcactgg	CRISPR spacer
tcgaccagcccggccgcccgcgtgtc	Protospacer
  *******************..

77. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP054032 (Rhizobium sp. JKLM13E plasmid pPR13E01, complete sequence) position: , mismatch: 7, identity: 0.731

gagaccagcccggccgcccgcactgg	CRISPR spacer
tcgaccagcccggccgcccgcgtgtc	Protospacer
  *******************..

78. spacer 19.3|7625340|26|NC_021191|CRT matches to NZ_CP022565 (Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK01, complete sequence) position: , mismatch: 7, identity: 0.731

gagaccagcccggccgcccgcactgg	CRISPR spacer
tcgaccagcccggccgcccgcgtatc	Protospacer
  *******************..

79. spacer 19.6|7625512|29|NC_021191|CRT matches to NZ_CP033228 (Sphingobium yanoikuyae strain SJTF8 plasmid pF2, complete sequence) position: , mismatch: 7, identity: 0.759

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
tcggcgatgcagccgggcggcagcgcgat	Protospacer
  *****  ***************** .

80. spacer 19.6|7625512|29|NC_021191|CRT matches to NC_019408 (Caulobacter phage CcrRogue, complete genome) position: , mismatch: 7, identity: 0.759

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
caggcgaaccagccgagcggcaggagcag	Protospacer
 **************.******* . ..*

81. spacer 19.6|7625512|29|NC_021191|CRT matches to NZ_CP019603 (Croceicoccus marinus strain E4A9 plasmid pCME4A9I, complete sequence) position: , mismatch: 7, identity: 0.759

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
ggcgcgaaccggcagggcggcagcgcgca	Protospacer
*. *******.** ************  .

82. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 8, identity: 0.742

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
cggcggccgtgtcgccgctcgccggcgccgt	Protospacer
  . *****. ******************.

83. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 8, identity: 0.742

gcagggccgcctcgccgctcgcc-----ggcgccag	CRISPR spacer
ccagggccgcctcgccgctctccacatagac-----	Protospacer
 ******************* **     *.*

84. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.742

gcagggccgcctcgccgctcgcc-----ggcgccag	CRISPR spacer
ccagggccgcctcgccgctctccacatagac-----	Protospacer
 ******************* **     *.*

85. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP021031 (Rhizobium sp. NXC14 plasmid pRspNXC14a, complete sequence) position: , mismatch: 8, identity: 0.742

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
ccgttgccgtctcgctgctcgccggcgccct	Protospacer
 *.  ****.*****.*************

86. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 8, identity: 0.742

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
tctccagcgcctcgcggctcgccggctccag	Protospacer
 *   . ******** ********** ****

87. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to MN234228 (Mycobacterium phage Tourach, complete genome) position: , mismatch: 8, identity: 0.742

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
gacccagcgcctcgccgctcaccgacgccag	Protospacer
*    . *************.***.******

88. spacer 19.2|7625286|30|NC_021191|CRT matches to NZ_CP015094 (Pelagibaca abyssi strain JLT2014 plasmid pPABY6, complete sequence) position: , mismatch: 8, identity: 0.733

cgagacaaaccagccagccagccgcgccag	CRISPR spacer
cgcatgcaaccagccggccagccgcgcctc	Protospacer
** .   ********.************

89. spacer 19.2|7625286|30|NC_021191|CRT matches to NZ_CP025431 (Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence) position: , mismatch: 8, identity: 0.733

cgagacaaaccagccagccagccgcgccag	CRISPR spacer
gggtttcagccagccatccagccgcgccag	Protospacer
 *.  . *.******* *************

90. spacer 19.2|7625286|30|NC_021191|CRT matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 8, identity: 0.733

cgagacaaaccagccagccagccgcgccag	CRISPR spacer
gggcgcaaaccagaccgccagccgcgccca	Protospacer
 *. .******** * ************ .

91. spacer 19.2|7625286|30|NC_021191|CRT matches to NZ_CP044989 (Deinococcus sp. AJ005 plasmid p380k, complete sequence) position: , mismatch: 8, identity: 0.733

cgagacaaaccagccagccagccgcgccag	CRISPR spacer
gtccatcacccagcctgccagccgcgccag	Protospacer
    *. * ****** **************

92. spacer 19.6|7625512|29|NC_021191|CRT matches to NZ_CP030263 (Ensifer adhaerens strain Corn53 plasmid AA, complete sequence) position: , mismatch: 8, identity: 0.724

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
tcggcgaaccggccgggcgtcagcgaacc	Protospacer
  ********.******** *****

93. spacer 19.6|7625512|29|NC_021191|CRT matches to MF695815 (Klebsiella phage KPP5665-2, complete genome) position: , mismatch: 8, identity: 0.724

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
ccagcgacccagctgggcggcagcgcgtt	Protospacer
  .**** *****.************

94. spacer 19.6|7625512|29|NC_021191|CRT matches to MK416008 (Klebsiella phage ST405-OXA48phi1.3, complete genome) position: , mismatch: 8, identity: 0.724

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
ccagcgacccagctgggcggcagcgcgtt	Protospacer
  .**** *****.************

95. spacer 19.6|7625512|29|NC_021191|CRT matches to NZ_CP027613 (Klebsiella pneumoniae subsp. ozaenae strain AR_0096 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.724

gaggcgaaccagccgggcggcagcgctgg	CRISPR spacer
ccagcgacccagctgggcggcagcgcgtt	Protospacer
  .**** *****.************

96. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP014310 (Burkholderia sp. PAMC 26561 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.71

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
cggaagccgccgcgccgatcgccggcgccgt	Protospacer
  ...****** ***** ***********.

97. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.71

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
tgcccgccgcctcgccgttcgccgccgccct	Protospacer
     ************.****** ****

98. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP015881 (Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence) position: , mismatch: 9, identity: 0.71

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
gagacaccggctcgacgctcgccggcgccgc	Protospacer
* .. .*** **** **************.

99. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP032324 (Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence) position: , mismatch: 9, identity: 0.71

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
acagggcggcctcggcgctcgccgaggaggc	Protospacer
.****** ****** *********. *  .

100. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NZ_CP007515 (Rubrobacter radiotolerans strain RSPS-4 plasmid 1, complete sequence) position: , mismatch: 9, identity: 0.71

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
accttaccgcctcgccactcgccggctccga	Protospacer
.*   .**********.********* **..

101. spacer 10.1|4427604|31|NC_021191|CRISPRCasFinder matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 10, identity: 0.677

gcagggccgcctcgccgctcgccggcgccag	CRISPR spacer
atgcccccgccccgccgcttgccggcgcccc	Protospacer
...   *****.*******.*********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

367883 : 379868

Mycobacterium_phage(33.33%)

capsid,portal

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015618418.1\|367883_370370_+	hypothetical protein	A0A2P1N0G1	Streptomyces_phage	6.8e-64	38.7
WP_015618419.1\|370712_371039_+	hypothetical protein	NA	NA	NA	NA
WP_015618420.1\|371035_371284_+	hypothetical protein	A0A2L1IZR2	Gordonia_phage	5.6e-11	54.7
WP_015618421.1\|371280_371637_+	hypothetical protein	A0A1B0XUC9	Freshwater_phage	5.9e-14	42.0
WP_015618422.1\|371633_371858_+	hypothetical protein	NA	NA	NA	NA
WP_015618423.1\|371854_372667_+	hypothetical protein	NA	NA	NA	NA
WP_041831799.1\|372914_373310_+	hypothetical protein	A0A2H5BM35	Streptomyces_phage	4.7e-20	46.0
WP_015618426.1\|373426_373840_+	hypothetical protein	NA	NA	NA	NA
WP_084504000.1\|373873_374410_+	HNH endonuclease	G1FGL3	Mycobacterium_phage	2.0e-21	54.9
WP_015618428.1\|374418_376011_+	hypothetical protein	E0YQ02	Mycobacterium_phage	6.7e-49	37.1
WP_015618429.1\|376021_377422_+\|portal	phage portal protein	A0A1B1IN58	uncultured_Mediterranean_phage	2.2e-35	29.8
WP_015618430.1\|377425_378325_+	hypothetical protein	A0A1C9EHV4	Gordonia_phage	2.8e-36	39.0
WP_015618431.1\|378373_378877_+	hypothetical protein	NA	NA	NA	NA
WP_015618432.1\|378932_379868_+\|capsid	phage major capsid protein	M4WNL4	Mycobacterium_phage	3.4e-53	39.9

DBSCAN-SWA_2

1703471 : 1731976

Bacillus_phage(40.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015619630.1\|1703471_1704530_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4IY97	uncultured_Caudovirales_phage	2.7e-14	24.2
WP_015619631.1\|1704526_1705570_+	iron chelate uptake ABC transporter family permease subunit	NA	NA	NA	NA
WP_015619632.1\|1705581_1706364_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	9.7e-09	20.3
WP_157408258.1\|1706120_1708466_+	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	6.7e-05	51.9
WP_015619635.1\|1708512_1710258_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.4e-23	24.5
WP_015619636.1\|1710328_1731976_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	1.1e-45	27.6

DBSCAN-SWA_3

2924753 : 3011474

Mycobacterium_phage(50.0%)

integrase,protease,transposase

attL 2942436:2942454|attR 3016710:3016728

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015620644.1\|2924753_2925746_-\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_015620646.1\|2925851_2929928_-	hypothetical protein	NA	NA	NA	NA
WP_157408319.1\|2930712_2932176_-	recombinase	NA	NA	NA	NA
WP_157408320.1\|2932734_2933175_+	hypothetical protein	NA	NA	NA	NA
WP_015620649.1\|2933671_2933998_-	nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase	NA	NA	NA	NA
WP_157408321.1\|2933928_2934447_-	hypothetical protein	NA	NA	NA	NA
WP_157408322.1\|2938132_2939161_-	hypothetical protein	NA	NA	NA	NA
WP_015620654.1\|2939853_2941008_+\|integrase	site-specific integrase	E7EJR3	Mycobacterium_phage	3.2e-16	25.3
WP_157408323.1\|2941070_2941286_-	excisionase family DNA-binding protein	NA	NA	NA	NA
WP_015620657.1\|2942138_2943137_-\|transposase	IS481 family transposase	NA	NA	NA	NA
2942436:2942454	attL	NA	NA	NA	NA
WP_084504098.1\|2943449_2944832_-	restriction endonuclease	NA	NA	NA	NA
WP_041832164.1\|2945891_2946227_+	hypothetical protein	NA	NA	NA	NA
WP_015620661.1\|2948304_2952303_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_015620662.1\|2952295_2953219_-	AAA domain-containing protein	NA	NA	NA	NA
WP_015620663.1\|2953215_2955228_-	hypothetical protein	NA	NA	NA	NA
WP_084504101.1\|2955224_2956160_-	hypothetical protein	NA	NA	NA	NA
WP_084504102.1\|2956517_2957036_-	phosphotransferase	NA	NA	NA	NA
WP_157408765.1\|2957265_2957589_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_015620667.1\|2957628_2957874_-	hypothetical protein	NA	NA	NA	NA
WP_041832168.1\|2957956_2958379_-	hypothetical protein	NA	NA	NA	NA
WP_041832169.1\|2958808_2959084_-	hypothetical protein	NA	NA	NA	NA
WP_015620669.1\|2959080_2959629_-	hypothetical protein	NA	NA	NA	NA
WP_041832170.1\|2959778_2960051_-	hypothetical protein	NA	NA	NA	NA
WP_015620673.1\|2960386_2960761_+	hypothetical protein	NA	NA	NA	NA
WP_157408324.1\|2960827_2961787_+	DUF4365 domain-containing protein	NA	NA	NA	NA
WP_015620674.1\|2961996_2963649_+	hypothetical protein	NA	NA	NA	NA
WP_015620675.1\|2964025_2968279_+	AAA family ATPase	NA	NA	NA	NA
WP_015620676.1\|2968275_2969121_+	TIGR02391 family protein	A0A1S5SBU1	Streptococcus_phage	2.2e-22	31.4
WP_157408325.1\|2969503_2970532_-	hypothetical protein	NA	NA	NA	NA
WP_015620681.1\|2971141_2971423_+	hypothetical protein	NA	NA	NA	NA
WP_015620682.1\|2971715_2973137_+	alpha-L-arabinofuranosidase B catalytic	NA	NA	NA	NA
WP_084504105.1\|2973180_2974818_+	alpha-galactosidase	NA	NA	NA	NA
WP_157408766.1\|2975515_2976478_+	exo-alpha-sialidase	NA	NA	NA	NA
WP_015620687.1\|2976697_2977993_-	DUF4832 domain-containing protein	NA	NA	NA	NA
WP_015620688.1\|2977997_2978807_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_015620689.1\|2978799_2979702_-	sugar ABC transporter permease	NA	NA	NA	NA
WP_041833478.1\|2979704_2980961_-	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_051167430.1\|2981023_2982154_-	ROK family protein	NA	NA	NA	NA
WP_041832175.1\|2982198_2983452_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_157408767.1\|2983610_2986340_-	family 3 glycosyl hydrolase	NA	NA	NA	NA
WP_041832176.1\|2986729_2987122_-	hypothetical protein	NA	NA	NA	NA
WP_015620695.1\|2987220_2987400_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_084504106.1\|2987446_2988145_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_063642971.1\|2988527_2989259_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_157408326.1\|2989701_2989872_-	hypothetical protein	NA	NA	NA	NA
WP_157408327.1\|2990789_2992208_+	hypothetical protein	NA	NA	NA	NA
WP_051167433.1\|2992471_2993599_-	alkene reductase	NA	NA	NA	NA
WP_157408768.1\|2993875_2995240_-	MFS transporter	A0A0M3UL24	Mycobacterium_phage	2.9e-61	39.9
WP_084504107.1\|2995356_2997237_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_041833483.1\|2997235_2997841_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_015620707.1\|2998406_2999201_+	hypothetical protein	NA	NA	NA	NA
WP_015620708.1\|2999620_3000736_+\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	5.8e-07	27.3
WP_051167760.1\|3000792_3001083_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_157408328.1\|3002531_3003482_+	hypothetical protein	NA	NA	NA	NA
WP_015620711.1\|3003487_3004597_-	hypothetical protein	NA	NA	NA	NA
WP_015620712.1\|3004850_3005855_+	SRPBCC family protein	NA	NA	NA	NA
WP_015620713.1\|3005851_3007027_+	glutathione-dependent formaldehyde dehydrogenase	NA	NA	NA	NA
WP_084504108.1\|3007140_3007614_+	hypothetical protein	NA	NA	NA	NA
WP_157408329.1\|3007852_3008872_-	hypothetical protein	NA	NA	NA	NA
WP_015620716.1\|3009539_3011474_-\|protease	trypsin-like serine protease	NA	NA	NA	NA
3016710:3016728	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NC_021191.1|WP_041832164.1|2945891_2946227_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_021191.1|WP_041832164.1|2945891_2946227_+|hypothetical-protein

2945891_2946227_+

111 aa aa

2924753-3011474

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_021191_17	Orphan	17.1\|7260368\|19\|NC_021191\|CRISPRCasFinder	7260368-7260386	19	2996657-2996675	2

1. spacer 17.1|7260368|19|NC_021191|CRISPRCasFinder matches to NC_021191 position: 2996657-2996675, mismatch: 2

gtctccaggacaccgaccg	CRISPR spacer
gtccccaggacaccgatcg	Protospacer
***.************.**

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_021191

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information