CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021281	Fusobacterium nucleatum subsp. animalis 4_8, complete sequence	6 crisprs	cas14j,cas6,cas5,cas3,cas4,cas1,cas2,DinG,PD-DExK,WYL,csa3	0	14	2	0
NC_021277	Fusobacterium nucleatum subsp. animalis 4_8 plasmid unnamed, complete sequence	0 crisprs	NA	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_021281_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021281_1

172969-176486

Unclear

Consensus_repeat	Method
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	PILER-CR
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CRISPRCasFinder
ATGAACTNTAAACTTGAAAAGTTTTGAAAT	CRT

53 spacers

cas2,cas1,cas4,cas3,cas5,cas6

The CRISPR arrays of NC_021281_1

>merge|NC_021281|1|172969-176486|PILER-CR,CRISPRCasFinder,CRT
ATGAACTGTAAACTTGAAAAGTTTTGAAATTAAATATTCCCTATTACTTCTATTCTTTTATTATTGTATGAACTGTAAACTTGAAAAGTTTTGAAATATTTTTGTCATTATAACTTACCTCCATATATTTAAATGAACTGTAAACTTGAAAAGTTTTGAAATCCTAAATATAGTTCAATGCTTGTGAATGCAGTAGACATGAACTGTAAACTTGAAAAGTTTTGAAATAAAATACAAGCCATTAATACTGTTAATAAAAATATCAATGAACTGTAAACTTGAAAAGTTTTGAAATAATTAATTCTCATATTTTCTACCTCCTAATTTTTATATGAACTGTAAACTTGAAAAGTTTTGAAATTTTTTGCCTCCTCTAGTGCAACTTTTTATTGCACCTATGAACTGTAAACTTGAAAAGTTTTGAAATTTTTTGCCTCCTCTAGTGCAACTTTTTATTGCACCATGAACTGTAAACTTGAAAAGTTTTGAAATTATTTTAAAAATAATGTCAATACACTTTTTAAAATAATGAACTGTAAACTTGAAAAGTTTTGAAATAGTGATGATGTTAGTGGATTTATGCAAGTTGAAGAATGAACTGTAAACTTGAAAAGTTTTGAAATCCATGTTTGGTCATCTTCAGATGGGAGCGAAGTTATATGAACTGTAAACTTGAAAAGTTTTGAAATTCTTTTACTTCAAGAAATTCTTTTACAATTTCTTTCATGAACTGTAAACTTGAAAAGTTTTGAAATATAACTGATACTACAAACATATCAGAAGTATCAGAATGAACTGTAAACTTGAAAAGTTTTGAAATTATATAAGTCAAGGCTCTCATGATGTTATGGATTCAAAATGAACTGTAAACTTGAAAAGTTTTGAAATAGCTAAAAATATTCTCTATAAGTATGTGAGGAAAAATGAACTGTAAACTTGAAAAGTTTTGAAATACTTAACGGAAAGATACTTAAAAGCTATGGATTAAATGAACTGTAAACTTGAAAAGTTTTGAAATATTTTAGAGGTTCATTGTTATAATGCTGGTAAAATATGAACTGTAAACTTGAAAAGTTTTGAAATTTTATAAATGTCAATATATTTTTATAACATTACAAATGAACTGTAAACTTGAAAAGTTTTGAAATAATTTATGTACAACCACACATTGAAATTCTTTCTTTTTATGAACTGTAAACTTGAAAAGTTTTGAAATTAGAAAAAAAAGAAATTCTCTTAATAGTTAAATCTATGAACTGTAAACTTGAAAAGTTTTGAAATGCTGAGGAGGCAAAAATGAAACAAATAAGAAAAAATATGAACTGTAAACTTGAAAAGTTTTGAAATTTTTATTCTATTAACATACATAAATAATAATTACTAATGAACTGTAAACTTGAAAAGTTTTGAAATCAGAAAAAAAAGAACTTCTTTTAATACTTAAAAGTAATGAACTGTAAACTTGAAAAGTTTTGAAATTTCTTAGAGGCTATAAATCTGAAATTATCTATCTTTATGAACTGTAAACTTGAAAAGTTTTGAAATAAGTTTGGTACACTATGTTTTTTCATATATCATTTATGAACTGTAAACTTGAAAAGTTTTGAAATTTCAGTAAAATTGAAAAAATGATAGCCTTAAAGCTAATGAACTGTAAACTTGAAAAGTTTTGAAATGGATTTGATTATAAATGGTGTTCATTTTGATAAGAATGAACTGTAAACTTGAAAAGTTTTGAAATATAAAAAAAATGATAGCCTTTTAAGCTACCACTTTATGAACTGTAAACTTGAAAAGTTTTGAAATTTAAAATTGATTTCCTCTTCTCTTTTGAATTTATAATGAACTGTAAACTTGAAAAGTTTTGAAATCTATAAACAATTTTATTGGATTATTGGATATTTACATGAACTGTAAACTTGAAAAGTTTTGAAATTGATATCAGATATGATATCTGATCATATGAATGCTTATGAACTGTAAACTTGAAAAGTTTTGAAATATAAAATATATAACAATAAAAGACATAAAAGATTGCATATGAACTGTAAACTTGAAAAGTTTTGAAATGTTGGTTGAACTATTAACATTGGACAAGGATCTAAAATGAACTGTAAACTTGAAAAGTTTTGAAATGGAAGTACATTGATTGCAGCAGAGCAATTAAACAGAATGAACTGTAAACTTGAAAAGTTTTGAAATAACAATGGTTTTAAAAAGAAATGGAATTGTCTTATCATGAACTGTAAACTTGAAAAGTTTTGAAATGTTTATGATACTGAACACTTTTTTAAGACAAAAGTATGAACTGTAAACTTGAAAAGTTTTGAAATTGACGATTCTGCTAGGCAGTTTAGTAAGATAGAAGTATGAACTGTAAACTTGAAAAGTTTTGAAATAATGAAGATGTTGATTGTTATGAACATACAGATTTATGAACTATAAACTTGAAAAGTTTTGAAATACTCTTCCACCAAGTAACTTATTATCATTAGTTAAAATGAACTATAAACTTGAAAAGTTTTGAAATACACAACTTACTAATGAAATAGATAGTTTTGTTGATATGAACTATAAACTTGAAAAGTTTTGAAATCTGTATTTAGTGTCTCCTAGCTTCAATCTTAATGTCTATGAACTATAAACTTGAAAAGTTTTGAAATTATGCAACTGTAAACTTCACATCTTCCCCAAAGTCATGAACTATAAACTTGAAAAGTTTTGAAATTAAGTTGCCCCTGCTGTTGTTCCAAGTTGTGCTCTATGAACTATAAACTTGAAAAGTTTTGAAATAATTAGAGACTTCTATCATATAGCTTTACCACTTTATATGAACTATAAACTTGAAAAGTTTTGAAATTCAAGTTAGTTTCAAGCAACTTATCAGCTTTTAATATGAACTATAAACTTGAAAAGTTTTGAAATCTGATATACAAACAGCAGATATGCTAAACTTACCTAATGAACTATAAACTTGAAAAGTTTTGAAATGGATATACTCCCGACATCATATAAGTGCTTTCTCATGAACTATAAACTTGAAAAGTTTTGAAATACTCTTCCACCAAGTAACTTATTATCATTAGTTAAAATGAACTATAAACTTGAAAAGTTTTGAAATTATATTCGTTGAATTTCTCAACTGCTTGATAGCCTGATGAACTATAAACTTGAAAAGTTTTGAAATATATTCTAATCCAGGAAGAGTTGGTGTAGCATTTGCAATGAACTAGAAACTTGAAAAGTTTTGAAATCACACAAAAATATCCAACCTACAAAAACTAAAATGCATGAACTATAAACTTGAAAAGTTTTGAAATTTATATATCTTTACAAGCTTTTCTCTTCTATTTGGATGAACTATAAACTTGAAAAGTTTTGAAATCTTATAGCATTATATGAAACCCTATAATTTTCTTTAATGAACTATAAACAGAAAATTAGTAATATCAGAAGCAAATAACAGATTATCCCTATAATTTTCTTTAATGAACTATAAACTAAAAAAATTTTGTTGT

>NC_021281|1|1|172969-176353|PILER-CR
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TAAATATTCCCTATTACTTCTATTCTTTTATTATTGT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATTTTTGTCATTATAACTTACCTCCATATATTTAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CCTAAATATAGTTCAATGCTTGTGAATGCAGTAGAC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AAAATACAAGCCATTAATACTGTTAATAAAAATATCA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AATTAATTCTCATATTTTCTACCTCCTAATTTTTAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTTTGCCTCCTCTAGTGCAACTTTTTATTGCACCT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTTTGCCTCCTCTAGTGCAACTTTTTATTGCACC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TATTTTAAAAATAATGTCAATACACTTTTTAAAATA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AGTGATGATGTTAGTGGATTTATGCAAGTTGAAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CCATGTTTGGTCATCTTCAGATGGGAGCGAAGTTAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TCTTTTACTTCAAGAAATTCTTTTACAATTTCTTTC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATAACTGATACTACAAACATATCAGAAGTATCAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TATATAAGTCAAGGCTCTCATGATGTTATGGATTCAAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AGCTAAAAATATTCTCTATAAGTATGTGAGGAAAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ACTTAACGGAAAGATACTTAAAAGCTATGGATTAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATTTTAGAGGTTCATTGTTATAATGCTGGTAAAAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTATAAATGTCAATATATTTTTATAACATTACAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AATTTATGTACAACCACACATTGAAATTCTTTCTTTTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TAGAAAAAAAAGAAATTCTCTTAATAGTTAAATCT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GCTGAGGAGGCAAAAATGAAACAAATAAGAAAAAAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTTATTCTATTAACATACATAAATAATAATTACTA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CAGAAAAAAAAGAACTTCTTTTAATACTTAAAAGTA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTCTTAGAGGCTATAAATCTGAAATTATCTATCTTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AAGTTTGGTACACTATGTTTTTTCATATATCATTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTCAGTAAAATTGAAAAAATGATAGCCTTAAAGCTA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GGATTTGATTATAAATGGTGTTCATTTTGATAAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATAAAAAAAATGATAGCCTTTTAAGCTACCACTTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTAAAATTGATTTCCTCTTCTCTTTTGAATTTATA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CTATAAACAATTTTATTGGATTATTGGATATTTAC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TGATATCAGATATGATATCTGATCATATGAATGCTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATAAAATATATAACAATAAAAGACATAAAAGATTGCAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GTTGGTTGAACTATTAACATTGGACAAGGATCTAAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GGAAGTACATTGATTGCAGCAGAGCAATTAAACAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AACAATGGTTTTAAAAAGAAATGGAATTGTCTTATC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GTTTATGATACTGAACACTTTTTTAAGACAAAAGT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TGACGATTCTGCTAGGCAGTTTAGTAAGATAGAAGT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AATGAAGATGTTGATTGTTATGAACATACAGATTT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ACTCTTCCACCAAGTAACTTATTATCATTAGTTAAA
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ACACAACTTACTAATGAAATAGATAGTTTTGTTGAT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	CTGTATTTAGTGTCTCCTAGCTTCAATCTTAATGTCT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TATGCAACTGTAAACTTCACATCTTCCCCAAAGTC
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TAAGTTGCCCCTGCTGTTGTTCCAAGTTGTGCTCT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	AATTAGAGACTTCTATCATATAGCTTTACCACTTTAT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TCAAGTTAGTTTCAAGCAACTTATCAGCTTTTAAT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	CTGATATACAAACAGCAGATATGCTAAACTTACCTA
ATGAACTATAAACTTGAAAAGTTTTGAAAT	GGATATACTCCCGACATCATATAAGTGCTTTCTC
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ACTCTTCCACCAAGTAACTTATTATCATTAGTTAAA
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TATATTCGTTGAATTTCTCAACTGCTTGATAGCCTG
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ATATTCTAATCCAGGAAGAGTTGGTGTAGCATTTGCA
ATGAACTAGAAACTTGAAAAGTTTTGAAAT	CACACAAAAATATCCAACCTACAAAAACTAAAATGC
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TTATATATCTTTACAAGCTTTTCTCTTCTATTTGG
ATGAACTATAAACTTGAAAAGTTTTGAAAT

>NC_021281|1|1|172969-176353|CRISPRCasFinder
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TAAATATTCCCTATTACTTCTATTCTTTTATTATTGT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATTTTTGTCATTATAACTTACCTCCATATATTTAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CCTAAATATAGTTCAATGCTTGTGAATGCAGTAGAC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AAAATACAAGCCATTAATACTGTTAATAAAAATATCA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AATTAATTCTCATATTTTCTACCTCCTAATTTTTAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTTTGCCTCCTCTAGTGCAACTTTTTATTGCACCT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTTTGCCTCCTCTAGTGCAACTTTTTATTGCACC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TATTTTAAAAATAATGTCAATACACTTTTTAAAATA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AGTGATGATGTTAGTGGATTTATGCAAGTTGAAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CCATGTTTGGTCATCTTCAGATGGGAGCGAAGTTAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TCTTTTACTTCAAGAAATTCTTTTACAATTTCTTTC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATAACTGATACTACAAACATATCAGAAGTATCAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TATATAAGTCAAGGCTCTCATGATGTTATGGATTCAAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AGCTAAAAATATTCTCTATAAGTATGTGAGGAAAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ACTTAACGGAAAGATACTTAAAAGCTATGGATTAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATTTTAGAGGTTCATTGTTATAATGCTGGTAAAAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTATAAATGTCAATATATTTTTATAACATTACAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AATTTATGTACAACCACACATTGAAATTCTTTCTTTTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TAGAAAAAAAAGAAATTCTCTTAATAGTTAAATCT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GCTGAGGAGGCAAAAATGAAACAAATAAGAAAAAAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTTATTCTATTAACATACATAAATAATAATTACTA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CAGAAAAAAAAGAACTTCTTTTAATACTTAAAAGTA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTCTTAGAGGCTATAAATCTGAAATTATCTATCTTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AAGTTTGGTACACTATGTTTTTTCATATATCATTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTCAGTAAAATTGAAAAAATGATAGCCTTAAAGCTA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GGATTTGATTATAAATGGTGTTCATTTTGATAAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATAAAAAAAATGATAGCCTTTTAAGCTACCACTTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTAAAATTGATTTCCTCTTCTCTTTTGAATTTATA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CTATAAACAATTTTATTGGATTATTGGATATTTAC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TGATATCAGATATGATATCTGATCATATGAATGCTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATAAAATATATAACAATAAAAGACATAAAAGATTGCAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GTTGGTTGAACTATTAACATTGGACAAGGATCTAAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GGAAGTACATTGATTGCAGCAGAGCAATTAAACAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AACAATGGTTTTAAAAAGAAATGGAATTGTCTTATC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GTTTATGATACTGAACACTTTTTTAAGACAAAAGT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TGACGATTCTGCTAGGCAGTTTAGTAAGATAGAAGT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AATGAAGATGTTGATTGTTATGAACATACAGATTT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ACTCTTCCACCAAGTAACTTATTATCATTAGTTAAA
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ACACAACTTACTAATGAAATAGATAGTTTTGTTGAT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	CTGTATTTAGTGTCTCCTAGCTTCAATCTTAATGTCT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TATGCAACTGTAAACTTCACATCTTCCCCAAAGTC
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TAAGTTGCCCCTGCTGTTGTTCCAAGTTGTGCTCT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	AATTAGAGACTTCTATCATATAGCTTTACCACTTTAT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TCAAGTTAGTTTCAAGCAACTTATCAGCTTTTAAT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	CTGATATACAAACAGCAGATATGCTAAACTTACCTA
ATGAACTATAAACTTGAAAAGTTTTGAAAT	GGATATACTCCCGACATCATATAAGTGCTTTCTC
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ACTCTTCCACCAAGTAACTTATTATCATTAGTTAAA
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TATATTCGTTGAATTTCTCAACTGCTTGATAGCCTG
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ATATTCTAATCCAGGAAGAGTTGGTGTAGCATTTGCA
ATGAACTAGAAACTTGAAAAGTTTTGAAAT	CACACAAAAATATCCAACCTACAAAAACTAAAATGC
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TTATATATCTTTACAAGCTTTTCTCTTCTATTTGG
ATGAACTATAAACTTGAAAAGTTTTGAAAT

>NC_021281|1|1|172969-176486|CRT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TAAATATTCCCTATTACTTCTATTCTTTTATTATTGT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATTTTTGTCATTATAACTTACCTCCATATATTTAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CCTAAATATAGTTCAATGCTTGTGAATGCAGTAGAC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AAAATACAAGCCATTAATACTGTTAATAAAAATATCA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AATTAATTCTCATATTTTCTACCTCCTAATTTTTAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTTTGCCTCCTCTAGTGCAACTTTTTATTGCACCT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTTTGCCTCCTCTAGTGCAACTTTTTATTGCACC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TATTTTAAAAATAATGTCAATACACTTTTTAAAATA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AGTGATGATGTTAGTGGATTTATGCAAGTTGAAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CCATGTTTGGTCATCTTCAGATGGGAGCGAAGTTAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TCTTTTACTTCAAGAAATTCTTTTACAATTTCTTTC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATAACTGATACTACAAACATATCAGAAGTATCAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TATATAAGTCAAGGCTCTCATGATGTTATGGATTCAAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AGCTAAAAATATTCTCTATAAGTATGTGAGGAAAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ACTTAACGGAAAGATACTTAAAAGCTATGGATTAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATTTTAGAGGTTCATTGTTATAATGCTGGTAAAAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTATAAATGTCAATATATTTTTATAACATTACAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AATTTATGTACAACCACACATTGAAATTCTTTCTTTTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TAGAAAAAAAAGAAATTCTCTTAATAGTTAAATCT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GCTGAGGAGGCAAAAATGAAACAAATAAGAAAAAAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTTTATTCTATTAACATACATAAATAATAATTACTA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CAGAAAAAAAAGAACTTCTTTTAATACTTAAAAGTA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTCTTAGAGGCTATAAATCTGAAATTATCTATCTTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AAGTTTGGTACACTATGTTTTTTCATATATCATTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTCAGTAAAATTGAAAAAATGATAGCCTTAAAGCTA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GGATTTGATTATAAATGGTGTTCATTTTGATAAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATAAAAAAAATGATAGCCTTTTAAGCTACCACTTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TTAAAATTGATTTCCTCTTCTCTTTTGAATTTATA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	CTATAAACAATTTTATTGGATTATTGGATATTTAC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TGATATCAGATATGATATCTGATCATATGAATGCTT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	ATAAAATATATAACAATAAAAGACATAAAAGATTGCAT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GTTGGTTGAACTATTAACATTGGACAAGGATCTAAA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GGAAGTACATTGATTGCAGCAGAGCAATTAAACAGA
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AACAATGGTTTTAAAAAGAAATGGAATTGTCTTATC
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	GTTTATGATACTGAACACTTTTTTAAGACAAAAGT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	TGACGATTCTGCTAGGCAGTTTAGTAAGATAGAAGT
ATGAACTGTAAACTTGAAAAGTTTTGAAAT	AATGAAGATGTTGATTGTTATGAACATACAGATTT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ACTCTTCCACCAAGTAACTTATTATCATTAGTTAAA
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ACACAACTTACTAATGAAATAGATAGTTTTGTTGAT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	CTGTATTTAGTGTCTCCTAGCTTCAATCTTAATGTCT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TATGCAACTGTAAACTTCACATCTTCCCCAAAGTC
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TAAGTTGCCCCTGCTGTTGTTCCAAGTTGTGCTCT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	AATTAGAGACTTCTATCATATAGCTTTACCACTTTAT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TCAAGTTAGTTTCAAGCAACTTATCAGCTTTTAAT
ATGAACTATAAACTTGAAAAGTTTTGAAAT	CTGATATACAAACAGCAGATATGCTAAACTTACCTA
ATGAACTATAAACTTGAAAAGTTTTGAAAT	GGATATACTCCCGACATCATATAAGTGCTTTCTC
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ACTCTTCCACCAAGTAACTTATTATCATTAGTTAAA
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TATATTCGTTGAATTTCTCAACTGCTTGATAGCCTG
ATGAACTATAAACTTGAAAAGTTTTGAAAT	ATATTCTAATCCAGGAAGAGTTGGTGTAGCATTTGCA
ATGAACTAGAAACTTGAAAAGTTTTGAAAT	CACACAAAAATATCCAACCTACAAAAACTAAAATGC
ATGAACTATAAACTTGAAAAGTTTTGAAAT	TTATATATCTTTACAAGCTTTTCTCTTCTATTTGG
ATGAACTATAAACTTGAAAAGTTTTGAAAT	CTTATAGCATTATATGAAACCCTATAATTTTCTTTA
ATGAACTATAAACAGAAAATTAGTAATATC	AGAAGCAAATAACAGATTATCCCTATAATTTTCTTTA
ATGAACTATAAACTAAAAAAATTTTGTTGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021281.1\|WP_008798986.1\|177204_177939_+\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176506
NC_021281.1\|WP_005910148.1\|187481_188561_+\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061
NC_021281.1\|WP_016339465.1\|189080_191324_+\|translation-initiation-factor-IF-2	unknown	unknown	gnl\|CDD\|235401
NC_021281.1\|WP_008798590.1\|186983_187454_+\|ribosome-maturation-factor-RimP	unknown	unknown	gnl\|CDD\|223850
NC_021281.1\|WP_008798982.1\|170994_171483_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_021281.1\|WP_008798987.1\|179988_181377_+\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|238520
NC_021281.1\|WP_008798977.1\|164171_164915_+\|CRISPR-associated-protein	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_021281.1\|WP_008798988.1\|181386_181746_+\|nucleotide-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|212142
NC_021281.1\|WP_008694682.1\|188553_189084_+\|DUF448-domain-containing-protein	unknown	unknown	gnl\|CDD\|225350
NC_021281.1\|WP_005910167.1\|161684_162989_+\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NC_021281.1\|WP_005910153.1\|179317_179845_+\|macro-domain-containing-protein	unknown	unknown	gnl\|CDD\|394878
NC_021281.1\|WP_005904402.1\|176754_177009_+\|hypothetical-protein	unknown	unknown	unknown
NC_021281.1\|WP_008798976.1\|163115_163670_+\|HutD-family-protein	unknown	unknown	gnl\|CDD\|226281
NC_021281.1\|WP_008798984.1\|172511_172796_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_021281.1\|WP_008798983.1\|171494_172493_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NC_021281.1\|WP_016339464.1\|168446_170984_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|350688
NC_021281.1\|WP_016339459.1\|160240_161659_+\|pyruvate-kinase-PykF	unknown	unknown	gnl\|CDD\|181699
NC_021281.1\|WP_008794981.1\|158124_158868_+\|DUF4261-domain-containing-protein	unknown	unknown	gnl\|CDD\|379456
NC_021281.1\|WP_005910154.1\|177944_179309_+\|sodium:alanine-symporter-family-protein	unknown	unknown	gnl\|CDD\|224040
NC_021281.1\|WP_016339463.1\|167606_168377_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641

Protein	Function_ID	Function_description	E-value
NC_021281.1\|WP_008798590.1\|186983_187454_+\|ribosome-maturation-factor-RimP	gnl\|CDD\|223850	COG0779, COG0779, Uncharacterized protein conserved in bacteria [Function unknown].	4.2016e-49
NC_021281.1\|WP_016339465.1\|189080_191324_+\|translation-initiation-factor-IF-2	gnl\|CDD\|235401	PRK05306, infB, translation initiation factor IF-2; Validated.	0
NC_021281.1\|WP_008798984.1\|172511_172796_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.10557e-25
NC_021281.1\|WP_008798982.1\|170994_171483_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.46822e-53
NC_021281.1\|WP_008798987.1\|179988_181377_+\|aminopeptidase-P-family-protein	gnl\|CDD\|238520	cd01087, Prolidase, Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.	6.60211e-101
NC_021281.1\|WP_008798977.1\|164171_164915_+\|CRISPR-associated-protein	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	4.0839e-08
NC_021281.1\|WP_008798988.1\|181386_181746_+\|nucleotide-pyrophosphohydrolase	gnl\|CDD\|212142	cd11535, NTP-PPase_SsMazG, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria. This family includes a MazG-like protein from Sulfolobus solfataricus (SsMazG) and its homologs from archaea and bacteria. Although its biological roles remain still unclear, SsMazG shows significant sequence similarity to the NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, SsMazG contains a single MazG-like domain. It is predicted that SsMazG might participate in house-cleaning by preventing incorporation of the oxidation product 2-oxo-(d)ATP (iso-dGTP), a mutagenic derivative of ATP, into DNA.	7.79231e-23
NC_021281.1\|WP_008694682.1\|188553_189084_+\|DUF448-domain-containing-protein	gnl\|CDD\|225350	COG2740, COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription].	3.80175e-23
NC_021281.1\|WP_005910167.1\|161684_162989_+\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NC_021281.1\|WP_005910153.1\|179317_179845_+\|macro-domain-containing-protein	gnl\|CDD\|394878	cd02908, Macro_OAADPr_deacetylase, macrodomain, O-acetyl-ADP-ribose (OAADPr) family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family includes eukaryotic macrodomain proteins such as human MacroD1 and MacroD2, and bacterial proteins such as Escherichia coli YmdB; these have been shown to be O-acetyl-ADP-ribose (OAADPr) deacetylases that efficiently catalyze the hydrolysis of OAADPr to produce ADP-ribose and free acetate. OAADPr is a sirtuin reaction product generated from the NAD+-dependent protein deacetylation reactions and has been implicated as a signaling molecule. By acting on mono-ADP-ribosylated substrates, OAADPr deacteylases may reverse cellular ADP-ribosylation.	9.67256e-84
NC_021281.1\|WP_008798976.1\|163115_163670_+\|HutD-family-protein	gnl\|CDD\|226281	COG3758, COG3758, Uncharacterized protein conserved in bacteria [Function unknown].	8.9793e-66
NC_021281.1\|WP_008798983.1\|171494_172493_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.30872e-151
NC_021281.1\|WP_008798986.1\|177204_177939_+\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176506	cd08563, GDPD_TtGDE_like, Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase (TtGDE, EC 3.1.4.46) and its uncharacterized homologs. Members in this family show high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. Despite the fact that most of GDPD family members exist as the monomer, TtGDE can function as a dimeric unit. Its catalytic mechanism is based on the general base-acid catalysis, which is similar to that of phosphoinositide-specific phospholipases C (PI-PLCs, EC 3.1.4.11). A divalent metal cation is required for the enzyme activity of TtGDE.	1.32056e-117
NC_021281.1\|WP_005910148.1\|187481_188561_+\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	2.80144e-149
NC_021281.1\|WP_016339464.1\|168446_170984_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	7.81762e-30
NC_021281.1\|WP_016339459.1\|160240_161659_+\|pyruvate-kinase-PykF	gnl\|CDD\|181699	PRK09206, PRK09206, pyruvate kinase PykF.	0
NC_021281.1\|WP_008794981.1\|158124_158868_+\|DUF4261-domain-containing-protein	gnl\|CDD\|379456	pfam14080, DUF4261, Domain of unknown function (DUF4261). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, and is approximately 80 amino acids in length.	3.75597e-24
NC_021281.1\|WP_005910154.1\|177944_179309_+\|sodium:alanine-symporter-family-protein	gnl\|CDD\|224040	COG1115, AlsT, Na+/alanine symporter [Amino acid transport and metabolism].	3.45007e-158
NC_021281.1\|WP_016339463.1\|167606_168377_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	7.15198e-50

>NC_021281.1|WP_008798984.1|172511_172796_+|CRISPR-associated-endonuclease-Cas2
MKNINYNYAWVFYDVSEKRVNKVFKICKKYLFHFQKSVFRGDITPSKLISLRSELKSIIVENEDFVCILKSISPDVFGEETLGNPTPNGENIFL
>NC_021281.1|WP_008798983.1|171494_172493_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MGSTKYITSMGELSRKDNSLCFRKNGKNIYIPIENTKEIYCLNEVSFNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPRNQYNSGKLLVKQVEKYKNNRIDIAKAIVKGIGANIDEVLYHYYKHGKSEVRDCIDWIREELYELVDKTESVKELLAYEGEIWMKFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKPIIVYKTIFDLVNNKRIQVAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLHTKLNRKISYRTAIKLDCYKLIKNILEDKEFIPFSLKNSY
>NC_021281.1|WP_008798982.1|170994_171483_+|CRISPR-associated-protein-Cas4
MNGTMINYYFHCKRQCYMFAHRLNLEDNSEIVKIGKAIHEDRARNSENTEIKIENIALDKINSKYVTEVKKSDADVEASKWQLLYYLKILKDKGIERKGKLEFIEKNKTDKKIVFVELDEDTERELEKHILEIEKLLEADELPKVINKASCKKCAYYEYCYI
>NC_021281.1|WP_016339464.1|168446_170984_+|CRISPR-associated-helicase/endonuclease-Cas3
MTKFEDIFDFQDKYKYLAHIKDNRKETLQEHTELANKYLKKIIEYKNLKPFFERIKNILNLKNIEEELFYKMISDVITFHDFGKINSQFQIDKMLNEEILKMEDKYNISGVLGSDHSLLSASMFIAYYFGKITDLIEIVETKKIVILFEILFALSYVISKHHGNLDSFEEYIEKLSRNNDENILKELKNISVSNGGILLQAFLEKETITIFFNFIETYISERKKKENISSHEAMSIFVFTKMMFSLLVASDYYSTNEFMQEIKYEDFGNMGNIDTIKKEYENSEIIKSIRDKEKNGIPNDEDINNFRTKIFLEAEKNLEKNKDSNIFFLEAPTGSGKSNTALNLSLKLLSENRRKIFYVYPFNTLVEQNMNTLKNIFENNEEVIKNIAVVNSVTALTNKDSRDISIEEYSDILMDRQFLNYPFIVTTHVGIFNSLVGNTKEDCMPFYQLANSVIVFDEIQAYKNTIWTEIIKILNSYAKLINIKIIIMSATLPNLSYLLDEEEKNNISKLIENRDEYFNNAIFKNRVEVNYDLLSEQKIEYEELLEHIIENSLNNQKILIEFISKNDAKKFYELCENNEDLNIKYEILLLTGEDNKARRNSIIKKINSKDKRVILISTQLIEAGVDIDVDVGYKNISGLDNEEQFLGRINRSCKKSGKAYFFYLTDAKKVYKNSVIIENKLNLFSDEMRDVLENKNFDVFYSKVLEILKRKAKEKINNDNFETIIFNKKFRLLKERMKLIEEQDDKKTYFFNRTLTNEEIEEIGENIDGSEVWERYVDILKEENYAKKIVELSKIREKMMYFLYEVKKNVELNYSDIKGSIIYIDDGDEYFTDGVYTGGEGDMFI
>NC_021281.1|WP_016339463.1|167606_168377_+|type-I-B-CRISPR-associated-protein-Cas5
MEALKFTLSGNSAFFKDNVINTVYLTYGNIHRVALLGMFGAILGYGGYSKQNDMLKKKNKKMPDYPEFYEKLKDIKISIVSNGKNGYFNKKLQTFNNSVGYASKEEGGNLIVKQFWLENPSWDIYILLDCDEAKKIADYIQNRKAIYLPYLGSNDHLANIMDVEIIDIEEKMSSEDETIEILSMVKDSDISEKKKNVFSIDKNSIRDDIYKYSEYLPVTLSKELNQYEKEKMTITNMSVILKKSYYKVEDKNIVFY
>NC_021281.1|WP_008798977.1|164171_164915_+|CRISPR-associated-protein
MEVYEMKLKVKLKKDIFLKDVSTYITRFMDMNLSANPTMYNYHTSKIYKGYTFDGLFPIEEDKIYKKDKTYSFRVRTINQKIANYFLDTLMFFENKDIQGLTLNIRVIEKKLIEKLYTITPILMKTDEGYWRYSMTFEEFEKRLKINCLKKYLYFTENNDDITIDTELLKKLGEDKSDDIDLFTNIKFINRMPVPIIYKGRKLVGDKVELQVANNEKAQDIAYMLLGTGLLENCARGCGFLNFKNYE
>NC_021281.1|WP_008798976.1|163115_163670_+|HutD-family-protein
MNKVIKKDDWKVSVWSGGTTNEIFIYPENSSYVDRAFKARISVATTNNGEKSLFTNLPGVERYISKLSGDMKLQHTDHYDVDMEDYQIDRFRGDWETYSWGKYKDFNLMLKGIRGDLYYRQIRSKCRLHLEKDSTVVFLYVVDGKINVNGTDLETEDFYITDDNILDVFGNNPKIYYGFIKEWD
>NC_021281.1|WP_005910167.1|161684_162989_+|phosphopyruvate-hydratase
MTGIVDVIGREILDSRGNPTVEVDVILECGAIGRAAVPSGASTGSHEAVELRDEDKSRYLGKGVLKAVNNVNTEIREALLGMDALNQVAIDKIMIELDGTANKGRLGANAILGVSLAVSKAAAEALGQPLYKYLGGVNAKELPLPMMNILNGGAHADSAVDVQEFMIQPVGAKSFREAMQMGAEVFHHLGKILKANGDSTNVGNEGGYAPSKIQGTEGALSLISEAVKAAGYELGKDITFALDAASSEFCEKVNGEYQYHFKREGGIVRNTDAMIKWYEELINKYPIVSIEDGLGEDDWDGWVKLTQAIGDRVQIVGDDLFVTNTERLKKGIELGAGNSILIKLNQIGSLTETLDAIEMAKRAGYTAVVSHRSGETEDATIADVAVATNAGQIKTGSTSRTDRMAKYNQLLRIEEELGSVAQYNGRSVFYNIKK
>NC_021281.1|WP_016339459.1|160240_161659_+|pyruvate-kinase-PykF
MKKTKIVCTIGPATESVETLKELLNRGMNVMRLNFSHGDYEEHGMRIKNFRQAMSETGIRGGLLLDTKGPEIRTMLLKDGKDVSIKAGQKFTFTTDQTVIGDNERVAVTYENFAKDLKVGDMVLVDDGLLELDVTEIKGNEVICIARNNGDLGQKKGINLPNVSVNLPALSEKDVEDLKFGCQNNIDFVAASFIRKADDVRQVRKVLQENGGEKVQIISKIESQEGLNNFDEILEASDGIMVARGDLGVEIPVEEVPCAQKMMIKKCNRAGKVVITATQMLDSMIKNPRPTRAEANDVANAIIDGTDAVMLSGETAKGKYPLEAVDVMNKIAKKVDSTIASFYVGRSNNRHDITSAVAEGSADISERLEAKLIVVGTESGRAARNMRRYFPKANILAITNNEKTANQLILSRGVIPYVDASPKTLEEFFILAETVAKRLKLVENGDIIVVTCGESVFIQGTTNSIKVIQVKA
>NC_021281.1|WP_008794981.1|158124_158868_+|DUF4261-domain-containing-protein
MSTSAFTGFVLLSEAKFDIDKFLKDLKEDWNITLNLGKENKEKDMLVGDIDGIMVAVALMPAPIPNNEAVESAKTNYKWKDAVKVAEEHKAHIIVSLLEEPNLVDGAKLYTKIISALTKQENCTGINVLGTVLNPDMYRDFTKYYEENNMFPVENMIFIGLYGSEDGKINAYTYGMEDFGKKEMEIIASSQKPEDVYYFLQGVADYVITSDVILQDGETIGFSAEQKIPISQSKGIAVNGTTLKLGY
>NC_021281.1|WP_005904402.1|176754_177009_+|hypothetical-protein
MKKFSIHGTEEGNTTSIKLDEIAILADPDTLLKIGEFIIKTAHVMKGYEVDYSQLQDEVSDFDYKNNTDIIIYNQDYDYKNDID
>NC_021281.1|WP_008798986.1|177204_177939_+|glycerophosphodiester-phosphodiesterase
MTKNFAHRGFSGKYPENTMLAFQKAIEVGADGIELDVQLTKDGEVVIIHDETIDRTTDGKGYVVDYTYKELSKFDASYIYRGKVGFSKIPTLKEYFELVKDLDFITNIELKTGINEYLGIEEKVYQLIKEYKLEKKVIISSFNHFSILRMKKIAPELKCGFLSEDWIIDAGAYTASHKIECFHPRFNNLIPEVVAELKKNNIEINTWTVNKEEDINDLIDKKVDILIGNYPDLVKKIINKKNRG
>NC_021281.1|WP_005910154.1|177944_179309_+|sodium:alanine-symporter-family-protein
MESLELFLTTINKWLWGRWLVYVLLGLGILYTFTNGFIQVRHFKFIIKKTLVDSFKARNDEKGSGSISTFKAMMVTLAGNVGGGNVVGVATAVAAGGMGAVFWMWVAAFFGMALKYGEIVLSQLYRGKDSEGNLLSGPMYYIRDGLKAPWLGVVIAVLMCTKMMGANLVQSNTISGVLSSNYNVPTWLTGVILICCLMAVVLGGLKRIANIATSLVPIMSIFYVVVGLLVILLNIQEVPSVIKEIFTQAFSMKAVAGGTGGYVIAKAMQYGITRGMYSNEAGEGTAPFAHGSAIVDHPCEEGITGVTEVFLDTIIICSITAIVIGVTGIYQSDLSPAVMAIESFGTVWGPLKHLATFALLLFCFTTLMGQWFNAAKSFTYAFGPKVTDKVRFVFPFLCIIGALTKISLVWTIQDIAMGLVIIPNLIALIILFPQVREQTKDYFSNPKFYPQDKK
>NC_021281.1|WP_005910153.1|179317_179845_+|macro-domain-containing-protein
MYKDIIKLVSGDITKVPEVEAIVNAANTSLEMGGGVCGAIFRAAGNDLTKECKEIGGCNTGEAVITKGYNLPNKYIIHTVGPRYSTGENGEAERLTSAYYESLKLAKKKGIRKIAFPSISTGIYRFPVDEGAEIALNTAIKFLDENPDSFDLILWVLDEKTYIVYKEKYEKLIKE
>NC_021281.1|WP_008798987.1|179988_181377_+|aminopeptidase-P-family-protein
MLNKEVYANRRKKLKENFKDGLILIMGNNFSPLDCEDNTYPFIQDATFKYYFGIDHNGLIGIIDIDKNEEIIFGNDYTMSDIIWMGKQKFLKELAIEVGIEKFSEKEELKKYLENRKNIRFTNQYRVDNIMYLSSILNINPFEFNKYTSFDLVKAIIKQRNIKDKIEIEEIEKAVNITREMHLSAMRNVKAGIKEYELVAEVEKQPRKYNAYYSFQTILSKNGQILHNHRHLNTLKDGDMVLLDCGALSDEGYCGDMTTTFPVSGKFTERQKNIHNIVRDMFDRAKELSKAGITYKEVHLEVCKLLAENMKKLGLMKGEVEDIVSAGAHALFMPHGLGHMMGMTVHDMENFGEINVGYDDGGKKSTQFGLSSLRLAKKLEIGNVFTIEPGIYFIPELFEKWKNEKLHEEFLNYDEIEKYMNFGGIRMERDVLIQEDGTSRILGDKFPRTADEIEEYMKVCGK
>NC_021281.1|WP_008798988.1|181386_181746_+|nucleotide-pyrophosphohydrolase
MGNTQQELLKKLSNKSSINEIQNYIKKIMEIRGFNQEKPSDKILLLVEEVGELAKAIRKNENKLGIDKTKECNYSSVESEVADIFIVLLSICDILNIDLFKVFLDKEEENIKRTWSMGE
>NC_021281.1|WP_008798590.1|186983_187454_+|ribosome-maturation-factor-RimP
MEGNNQIVEKITEIVNPFVEEMNLSLVDVEYVQDGAYWYIRIFIENLNGDLSIEDCSKLSSKIEDKIEKLIEHKFFLEVSSPGLERPLKKIEDYIRFTGEKITLHLKHKLDDKKQFKAIIKEVNGDNIIFLIDKKEIEIKFNEIRKTNILFEFNDF
>NC_021281.1|WP_005910148.1|187481_188561_+|transcription-termination/antitermination-protein-NusA
MKAKDSKNFLEALDELEKEKGISKESVLEAIELALLAAYKKNYGEDENVEVTVDRENGDIKVFASKTVVAADDLLDPNEEISLEDAKKIKKRVKIGDILKFEVDCENFRRNAVQNGKQIVIQKVREAEREHIFNKFKEREDSIVTGIIRRIDNRKNIFIEIDGVELILPPAEQSVSDIYRVGERIKVYVLSVEKTSKFPKILISRRNEGLLRKLFEIEIPEITSGIIEIKSVAREAGSRAKVAVYSAVPNIDTIGACIGQKGARIKNIVDELNGERIDIVEWKPVVEEFVSAVLSPAVVESVTILEDGTARVLVEPSQLSLAIGKNGQNARLAARLTGMRVDIKVIDKDKETLKEGEDE
>NC_021281.1|WP_008694682.1|188553_189084_+|DUF448-domain-containing-protein
MSNTHIPERTCIICRTKKEKSKLFRLAKLKETFYEFDKEQKKQSRAVYVCKSLNCLGKLAKHNKVKLDSQDLMSMLNIINKANKNYINILNSMKNSGELVFGINLLFENIEHVHFIVMAQDISKKNEEKIIRRINELKIPYVVVGSMQELGKVFNKEEITVIGIKDKKMARGLIEE
>NC_021281.1|WP_016339465.1|189080_191324_+|translation-initiation-factor-IF-2
MNKRLKEGEYMKVRVHELAKKHDIKNKEFLEILKKDIGINVTSHLSNLDEDQVKKIDDYFAKMNMLKVEMPEPTKAHKEKKEEKPIRKIMVEDENDENEGYSQKNNKKAKFQQTKNKKNNNITFDEDGNSHKNRSKKKKGRRTDFVLKTIEATPDVVEEDGIKIIKFRGELTLGDFAEKLGVNSAELIKKLFLKGQMLTINSPISLSMAEDLAADYDVLVEEEQEVELDFGEKFDLEIEDKAADLKERPPVITIMGHVDHGKTSLLDAIRTTNVVEGEAGGITQKIGAYQVVKDGKRITFIDTPGHEAFTDMRARGAQVTDIAILVVAADDGVMPQTVEAISHAKVAKVPIIVAVNKIDKPEANPMKVKQELMEHGIVSSEWGGDVEFVEVSAKKKINLDGLLDTILITAEILELKGNTKKRAKGVVLESRLDPKIGPIADILVQEGTLKIGDVIVAGEVQGKVKALLNDKGERVNNATVSQPVEVIGFNNVPDAGDTMYVIQNEQHAKRIVEEVRKERKIQETTKKTISLESLSDQFKHEDLKELNLILRADSKGSVDALRDSLLKLSNDEVAVSIIQAASGAITESDVKLAEAAGAIIIGYNVRPTTKALKEAEISKVEIRTSGIIYHITEDIEKALAGMLEPEYKEEYLGRIEIKKVFKVSKVGNVAGCVVIDGKVKNDSNIRILRDNVVIYEGKLASLKRFKDDAKEVVAGQECGLGVENFNDIKEGDVVEAFEMVEVKRTLK

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Crispr_ID: NC_021281_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021281_2

312280-312401

Orphan

Consensus_repeat	Method
TTTTTCAGGATTTTTTCAAGATAAAAAAAATCCTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021281_2

>merge|NC_021281|2|312280-312401|CRISPRCasFinder
TTTTTCAGGATTTTTTCAAGATAAAAAAAATCCTTTTCAAGATTTTTTTAAGATAAGTTGAGAATTTTTCCAGAATAAGTTAAAATTTTTTCAGGATTTTTTCAAGATAAAAAAATCCTTTT

>NC_021281|2|2|312280-312401|CRISPRCasFinder
TTTTTCAGGATTTTTTCAAGATAAAAAAAATCCTTTT	CAAGATTTTTTTAAGATAAGTTGAGAATTTTTCCAGAATAAGTTAAAA
TTTTTTCAGGATTTTTTCAAGATAAAAAAATCCTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021281.1\|WP_008694438.1\|327288_327774_+\|cytidine/deoxycytidylate-deaminase-family-protein	unknown	unknown	gnl\|CDD\|225042
NC_021281.1\|WP_008798519.1\|306932_307475_+\|ComEA-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|224472
NC_021281.1\|WP_008798508.1\|320944_322381_-\|leucyl-aminopeptidase	unknown	unknown	gnl\|CDD\|223338
NC_021281.1\|WP_008798517.1\|309003_309795_+\|TIGR00282-family-metallophosphoesterase	unknown	unknown	gnl\|CDD\|379099
NC_021281.1\|WP_032839812.1\|322639_327169_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377133
NC_021281.1\|WP_008798509.1\|319582_320053_+\|DUF523-domain-containing-protein	unknown	unknown	gnl\|CDD\|224597
NC_021281.1\|WP_008694468.1\|310750_312274_+\|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225420
NC_021281.1\|WP_008694466.1\|312432_313092_+\|(d)CMP-kinase	unknown	unknown	gnl\|CDD\|234579
NC_021281.1\|WP_016339506.1\|320281_320869_-\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
NC_021281.1\|WP_005910031.1\|308615_308882_-\|hypothetical-protein	unknown	unknown	unknown
NC_021281.1\|WP_016339504.1\|315833_317111_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NC_021281.1\|WP_016339500.1\|304573_305524_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	unknown	unknown	gnl\|CDD\|225364
NC_021281.1\|WP_008798513.1\|313104_313572_+\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|377965
NC_021281.1\|WP_016339505.1\|317372_319565_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|227634
NC_021281.1\|WP_016339503.1\|313584_315507_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|224436
NC_021281.1\|WP_016339502.1\|309775_310708_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|225173
NC_021281.1\|WP_016339499.1\|302835_304338_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl\|CDD\|223679
NC_021281.1\|WP_008798523.1\|302170_302722_-\|manganese-efflux-pump-MntP-family-protein	unknown	unknown	gnl\|CDD\|224882
NC_021281.1\|WP_008798518.1\|307462_308320_+\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|224200
NC_021281.1\|WP_016339501.1\|305526_306936_+\|coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236187

Protein	Function_ID	Function_description	E-value
NC_021281.1\|WP_008694438.1\|327288_327774_+\|cytidine/deoxycytidylate-deaminase-family-protein	gnl\|CDD\|225042	COG2131, ComEB, Deoxycytidylate deaminase [Nucleotide transport and metabolism].	4.78468e-62
NC_021281.1\|WP_008798519.1\|306932_307475_+\|ComEA-family-DNA-binding-protein	gnl\|CDD\|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	1.14895e-23
NC_021281.1\|WP_008798508.1\|320944_322381_-\|leucyl-aminopeptidase	gnl\|CDD\|223338	COG0260, PepB, Leucyl aminopeptidase [Amino acid transport and metabolism].	0
NC_021281.1\|WP_008798517.1\|309003_309795_+\|TIGR00282-family-metallophosphoesterase	gnl\|CDD\|379099	pfam13277, YmdB, YmdB-like protein. This family of putative phosphoesterases contains the B. subtilis protein YmdB.	1.22908e-152
NC_021281.1\|WP_008798509.1\|319582_320053_+\|DUF523-domain-containing-protein	gnl\|CDD\|224597	COG1683, COG1683, Uncharacterized conserved protein [Function unknown].	3.5108e-63
NC_021281.1\|WP_008694468.1\|310750_312274_+\|putative-DNA-binding-domain-containing-protein	gnl\|CDD\|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	1.04834e-36
NC_021281.1\|WP_008694466.1\|312432_313092_+\|(d)CMP-kinase	gnl\|CDD\|234579	PRK00023, cmk, (d)CMP kinase.	2.45922e-109
NC_021281.1\|WP_016339506.1\|320281_320869_-\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	1.76035e-62
NC_021281.1\|WP_032839812.1\|322639_327169_+\|hypothetical-protein	gnl\|CDD\|377133	pfam03797, Autotransporter, Autotransporter beta-domain. Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.	4.63483e-09
NC_021281.1\|WP_016339504.1\|315833_317111_+\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NC_021281.1\|WP_016339500.1\|304573_305524_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	gnl\|CDD\|225364	COG2805, PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion].	1.20575e-145
NC_021281.1\|WP_008798513.1\|313104_313572_+\|SH3-domain-containing-protein	gnl\|CDD\|377965	pfam08239, SH3_3, Bacterial SH3 domain.	1.04762e-06
NC_021281.1\|WP_016339505.1\|317372_319565_+\|metallophosphoesterase	gnl\|CDD\|227634	COG5324, COG5324, Uncharacterized conserved protein [Function unknown].	6.81032e-108
NC_021281.1\|WP_016339503.1\|313584_315507_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|224436	COG1519, KdtA, 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane].	1.19694e-150
NC_021281.1\|WP_016339502.1\|309775_310708_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|225173	COG2264, PrmA, Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis].	8.88719e-110
NC_021281.1\|WP_016339499.1\|302835_304338_+\|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NC_021281.1\|WP_008798523.1\|302170_302722_-\|manganese-efflux-pump-MntP-family-protein	gnl\|CDD\|224882	COG1971, COG1971, Predicted membrane protein [Function unknown].	2.03109e-41
NC_021281.1\|WP_008798518.1\|307462_308320_+\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|224200	COG1281, COG1281, Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones].	1.33526e-101
NC_021281.1\|WP_016339501.1\|305526_306936_+\|coproporphyrinogen-III-oxidase	gnl\|CDD\|236187	PRK08207, PRK08207, coproporphyrinogen III oxidase; Provisional.	0

>NC_021281.1|WP_008694468.1|310750_312274_+|putative-DNA-binding-domain-containing-protein
MNNEKTKLSFDLKKIKENENIEFKKADNNLPNSLWETYSAFCNTSGGIIILGIEEKKNGDNTIIGINDIDKMEKDIWNTANNSAKVSYNVIGNGDIYKVKIDDKNIMILDIKEAPHNKKPVYLNRKIENTYIRRGEADKKADNDEIGTLMAMATPKPLLLDNFSMKDLDRETVSKFRKIVEERYPEKNYKNLNDEDFLKEIGAIRLDRKNNIYKITDGCLLLLGKYISITDYFSKFHLDFFYRDKDNERWKDRVSSDLPNSYGEMNIFNFYNIVFEKIKIFLKEPFALNEEKVRVSNTSLLIEAIREALVNTLIHADYLQNFPKVKIEMFEGWINFENSGKMLITKDEYVQGGNSVIRNEILVQLVRLIGIAERQGFGGVKICKTSESLFKQQPEIITDLRETKLKLWTVDALHFREDLSVLDKKIYHILLKNNQPLTRKEIISISENTEHFVKKSLINLLEKGLITTIGNGRSTKYEISFGTQGYLTKIQMKLQTLAKLNNLLSED
>NC_021281.1|WP_016339502.1|309775_310708_+|50S-ribosomal-protein-L11-methyltransferase
MKVLEAKIIYESDDLEKYKKIISDIFYNFGVTGLKIEEPILNKDPLNFYKDEKQFLISENSVSAYFPLNIYSEKRKKVLEETFAEKFSEDEDIVYNLDFYEYDEEDYQNSWKKYLFVEKVSEKFVVKPTWREYEKQDNELVIELDPGRAFGTGSHPTTSLLLKLMEEQDFSNKSVIDIGTGSGILMIAGKFLGAGEVYGTDIDEFSMEVAKENLILNNISLNDVKLLKGNLLEVIENKKFDIVVCNILADVLVKLLDEIKYILKENSIVLFSGIIEDKLNEVISKAEDVGLEVVEVKADKEWRAVYFKRK
>NC_021281.1|WP_008798517.1|309003_309795_+|TIGR00282-family-metallophosphoesterase
MKVLVVGDIVGRPGRNTLQVFLEKYKDNYDFIIVNGENSAGGFGITIKITDEFLSWGVDVISGGNHSWDKKEIYEYMNNSDRILRPANYPEGVSGKGYTILEDKKGNKIALISLQGRVFMSAVDCPFRTAKKLIDEISKITKNIIVDFHAEATSEKIALGKYLDGDISLFYGTHTHVQTADERILNNGTGYISDIGMTGSQNGVIGTNLETIINKFLTSLPQKFEVAEGDEQLCGIEVEIDEKTGKCQKIERIKWSENEGFRS
>NC_021281.1|WP_005910031.1|308615_308882_-|hypothetical-protein
MNINVCKKILNSVLFFIAFMIVAFVINTFLFKFRFSETAPSIYEAIPGAIGGTLATAFFVKKDIKKSDIYFLIIIIILAIAVYFFVLN
>NC_021281.1|WP_008798518.1|307462_308320_+|Hsp33-family-molecular-chaperone-HslO
MGRLIRGISKNARFFVADTTDVVQEVLDIHKYDEYSMKIFGKFCTLAGLMGATLKGEDKLTIRTDTDGYIKNIVVTSDANGNIKGYLVNTTDENFDGLGKGTMRIIKDMGLKEPYVAISDIDYSNLPNDISSFFYNSEQIPTVISLAVENTNDGKILCAGAFMIQLLPNADEDFITKLERKAEAIRPMNELMKGGMSLEQIINLLYDDMDTEDDSLVEEYEILEEKEIKYSCDCSAERFQKGIMTLGKEELKHIFEEEKEIEAQCQFCGKKYKFTEKDFDDVLKK
>NC_021281.1|WP_008798519.1|306932_307475_+|ComEA-family-DNA-binding-protein
MKKLMLLLGIFSLFSLSLYPAPDLSNNDYKIIMSSQNMKDEKEELMDINKVSEQEMLARKVSKSYVSKIIEYREITGGFDKLEDMKRIKGIGDATYQKLSKFFKVGSEPNKKMLNINSANEITLKYYGFSKKEIKKIQKYLDKNDRITDNIEFQKIVNKKTYERLKDLINYDGGKREWED
>NC_021281.1|WP_016339501.1|305526_306936_+|coproporphyrinogen-III-oxidase
MLIETNVEVNLRSIEEFTRVMASELLEDKINFEILKEDNLIKIDVKSEKLNKNTEFSYIDLGNKIEDQILTMCKISLLKLLDKKYDWGSLMGVRPTKVLRRLLINGCDYEEARKILKDFYLVTDEKINLMETVIKKELELLDKEHINLYIGIPFCPTKCKYCSFASYEINGGVGRFYNDFVEALLKEIQIVGDFLKTYSKKVSSIYFGGGTPSTLTEEDLERVLRKLLENIDMSDVKEFTFEAGREDSLNTKKLEIMKKYFVDRISLNPQSFNLDTLKRVNRKFNRENFDLIFKEAKKLEFIINMDLIIGLPEETTEEILDTLSQLKDYDIDNLTIHCLAFKRASKLFKESQERNSIDRALIEKHIQKIVEEKTMKPYYMYRQKNIIEWGENIGYSKEGKESIFNIEMIEENQNTMALGGGGISKIVIEERNGIDYIERYVNPKDPALYIRELDKRCKEKIEMFKKEKI
>NC_021281.1|WP_016339500.1|304573_305524_+|Flp-pilus-assembly-complex-ATPase-component-TadA
MNIEKIFNYAKEKNISDIHLIEDEKIYFRKDGKIIEYSGTDTVSKEELLEICNGKIEEDFSYTDSKSQRYRVNSFLTRGKLALVIRIINKEPIKLKGKFINKLIDEKILSLKDGLVLVTGITGSGKSTTLANIIEKFNENKNLKILTIEDPIEYIFENKKSLIIQRELGEDVESFEKALKSSLRQDPDVIILGEIRDEESLYSALKLVETGHLVFSTLHTMNTVESVNRLISMVRSEKKDFIREQLTSVLRFILSQELYRGKKTVPIFEILNNTKAVANLILNNKLNQIPTLIESGIENFMITKSKYLKNLETESD
>NC_021281.1|WP_016339499.1|302835_304338_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MKKKIFTSSYLGLESYLVEVEVDISRGLPMFSIVGMGDTAILESKFRVKAALKNSNYEIVPQKIVVNLSPAGIKKEGAQFDLPIALGIILEMKLLKDKRDIFKNYLFVGELSLDGEVKGVSGTINSVILAKEKGFKGIIVPHENRNEASLIDGVDIVAVKNVADVINFIENGIKLEFEKINLVKTEEDILDFSDVKGQYFAKRAMEISAAGGHNILLIGSPGSGKSMLAKRMIGILPEMTESEIIESTKIYSVAGELSEKNPIISKRPMRMPHHSTTLAAMVGGGKKALPGEISLASNGILILDEMSEFKHSVLEALRQPLEDGYVSITRAMYRVEFRSNFILVGTSNPCPCGNLYEGNCKCSATEVERYTKKLSGPILDRIDLVIQMKRLSEEELVNDKKEESSANIRKRVIKARKIQTKRYGEAKTNSKMSQEELKKYCIIKEEDKRFLISALENLQISARVYDKILKIARTIADLAGEKEISRKHLLEAISFKNNRK
>NC_021281.1|WP_008798523.1|302170_302722_-|manganese-efflux-pump-MntP-family-protein
MSTIGVLITALALAMDAMSLSIYQGIASTESQKKQNFLKIVLTFGIFQFAMALVGSLSGTLFIHYISLYSKYVSFAIFLFLGLMMLKEALKKEEMKYEEKYLDFKTLIIMGIATSLDSLLVGLTFSILPFYQTFLYTVEIGIVTAIIAGLGFILGEKFGNILGQKSHFLGAALLIFIAINVLF
>NC_021281.1|WP_008694466.1|312432_313092_+|(d)CMP-kinase
MDNIIVAIDGPAGSGKSTIAKLIAKKFNFTYIDTGAMYRMITLYLLENNIDFDDLKEVEKALKNINLDMQGDKFYLNDIDVSTKIREKRINENVSKVASIKIVRDNLVNLQRKISNNKNVILDGRDIGTVVFPNAKVKIFLVATAEERARRRYNEFLEKKTKITYDEVLKSLKERDYIDSTRKESPLKKADDAIELDSTNLTIDDVVNFISKEIEKNIN
>NC_021281.1|WP_008798513.1|313104_313572_+|SH3-domain-containing-protein
MKKILMFMMFLILSLTSLAERFVVSSKDGYANLRKEATTNSKVIMKVDNSTQITLLFKNGDWYYVEIFKNNPLLYAEGYIHKSQLELHPETYVVFSKDGYANLRRGTTINSEILDVLDNGEYVTKLDEVGEWYRVEYAAFDGGYIHKSQLKKYTK
>NC_021281.1|WP_016339503.1|313584_315507_+|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MYNLLKKIALTLYRPFMKEKMKTFIEKRLSQDFSDLKDEEYIWIHCSSVGEVNLSEDLVKKFYSISRKNILISVFTDTGYENAVKKYSDKKKIKVIYFPVDDKKKINEILNKIKLKLLVLVETELWPNLINEVNEKNSRIIVVNGRISDRSYPRYKKLKFLLKSMLQKIDFFYMQSEIDKERIISLGADGNKTENVGNLKFSISLEKYSDIEKEEYRKFLNVGDRKVFVAGSTRTGEDEIILDVFKKIKNYVLIIVPRHLERLAKIENLIKENNLTYVKYSDLENKVSTRKEDIILVDKMGVLRKLYSISDIAFVGGTLVNIGGHNLLEPLFYRKAVIFGKYTQNVVDIAKEILRRKIGYQVENVEEFVKAIETIENEKNSDEEINSFFEENRLIALNIVKRENLIMNNIKEEAKDLWKHFFHSEKSNYNIYMYKLLDYPEYIMYDNDVMKEKKSKWSEYFGNSNPIAVEIGTGSGNFMYQLVERNPNKNFIGLELRFKRLVLAAEKCKKRNIKNVVFLRKRGEELEDFLADNEISEMYINFPDPWEGTEKNRIIQERLFKTLDKIMKKDGMLYFKTDHDMYYSDVLELVKTLDNYEVIYHTSDLHNSEKAENNIKTEFEQLFLHKHNKNINYIEIKKIV
>NC_021281.1|WP_016339504.1|315833_317111_+|adenylosuccinate-synthase
MAGYVVVGTQWGDEGKGKIIDVLSEKADYVVRFQGGNNAGHTVVVDGEKFVLQLLPSGVLQAGTCVIGPGVVVDPKVFLDEIDRIEKRGAKTDHVIISDRAHVVMPYHIEMDKIRESVEDRIKIGTTKKGIGPCYADKISRDGIRMADLLDLKQFEEKLRYNLKEKNEIFTKIYGLEPLDFDKIFEEYKGYAEKIKHRIVDTIPIVNKALNENKLVLFEGAQAMMLDINYGTYPYVTSSSPTLGGVTTGAGISPRKIDKGIGVMKAYTTRVGEGPFVTEIKGEFGDKIRGIGGEYGAVTGRPRRCGWLDLVVGRYATEINGLTDIVMTKIDVLSGLGKLKICTAYEIDGKIHEYVPADTKSLDRAIPIYEELDGWDEDITQIKKYEDLPVNCRKYLERVQEILACPISVVSVGPDRSQNIHIREI
>NC_021281.1|WP_016339505.1|317372_319565_+|metallophosphoesterase
MRTLLLLRGTQASGKSTWVTENNLEPYTLSADKIRLNIANPVLNEDGSIEISQKYNKLTWELLYKYLEMRMENGDFTIIDATHSDIKLMNKYRDLANIYKYTIYYLEFDTPLEECLKRNRERIGYKYVPEKVIERTWETIKNKEKLPSIFKKINSIDEIINFYTANVNEYKKVIIIGDIHSCTEPLKEVLKDFSEEDLYVFVGDYFDRGIQAVETFKIMLDLLEKSNVILVEGNHENNSVKKFINDEEKYTKSFDETTLQPLLKEFELDYIKSSLKKIYKRLRQCFAFEFRGKKFLCTHGGLPLVPKLALISAREMIKGVGRYETEIGEIYSENYKKGLCQDFIQVHGHRGINDGEYSYCLEGRVEFGGELKILTIDNDGNIEKYGIKNDVYNRGLTIATRDSSEKIKNFQTENELINEMIASSFITVKECDYNLISLNFNREAFNKKKWNDLTIKARGLFVDRDSGEVKIRSYNKFFNFGERHVNLGYLHKYATYPIRVFKKYNGFLGLASVIDGNIVFASKSVTSGKYKDIFQNIWNKVEAEVKELLKKTMIENNCTVVFEVVSPEYDPHIIKYDKEHLYLLDFIENKLDIDTHNIDLEFSENLMKKVEFSSTILTKKELITKLENYNELYNFLDEKAKSLEEFEGYVLCDNSGLMFKFKLPYYILWKERRTWLERYRSALSKGKKIEIKDIEKDENRHFKKFLLKLGKDKLQGLSIIDVREMYEKSL
>NC_021281.1|WP_008798509.1|319582_320053_+|DUF523-domain-containing-protein
MEKEIKVLISACLLGDNVKYSGGNNLTPELVTLLEKYNVKIVKICPECFAGLPIPRVPSEIREDKVYGKDGRDITEEFLVGAEKTYQIAKRKQVDFAILKERSPSCGSSYIYDGSFSGKVIQGQGLTARRLNKENIVIFSEENLEEIEKYLEELNK
>NC_021281.1|WP_016339506.1|320281_320869_-|YigZ-family-protein
MEKIKTVKKECKIEFEEKKSKFIGYIKPVFSKEEAEDYIKYIKNLHSDATHNCSAYKINNNGLEFFKVDDDGEPSGTAGKPMGDIINYMKVTNLVVIATRYFGGIKLGAGGLVRNYAKTAKLAITEAEIIDFVDKIDLIFEIPYERLGELEKLLKDYKAEIIEKSFLEKIIFKVKINKEFYDSLENYSYINLLDI
>NC_021281.1|WP_008798508.1|320944_322381_-|leucyl-aminopeptidase
MSFQCVKKYEDSYDKYVLVATSEKVVLPDYLDKESKKLAETIIKKNKFTAKSSEKISMTLVNKKKVIDFIIIGLGEKKKLNAKNIRQYLFDGLKNITGKVFLSFADKDLDDIDIIAEVVEHINYKFDKYLTKKKEEFLEVSYLTDKKVPKLIEGYELAKISNIVKDLVNEQAEVLNPKELANRATKLGKEFGFDVEILDEKKAQKLGMNAYLGVARAAHHRPNVIVMRYKGDAKSKYTYGLVGKGLTYDTGGLSLKPTDSMLTMRCDMGGAATMIGVMCSIAKMKIKKNVTCVVAACENSIGPNAYRPGDILTAMNGKTIEVTNTDAEGRLTLADALTYIVRKEKVNEVIDAATLTGAVMVALGEDVTGVFTNDDKMARKVIDASENWNEYFWQMPMFDIYKKNLKSPYADIQNTGVRWGGSTNAAKFLEEFVDDTKWVHLDIAGTAWASGANPYYSQKGATGQVFRTVYSYIKDSKN
>NC_021281.1|WP_032839812.1|322639_327169_+|hypothetical-protein
MFKNKYLFVLALLVTTTSYSENYTITQETKKEVKEILKHEKEDSSRLGKFAVSGNVVAFKGNGFLINNGILKGSIKADGEDTKNEKSKKGEIIVAAQGNGVLGVGYSPYSNKNDIDKKIDSVSNKGYISGEANLTGGNAERFGSIEEVYSTANGISGLALSDFGDTATGGSGDSGIVDGAGGASRSGRSKSVSLLSTKVLASKTAEKISENKIGEIKKTDPKDFYGKNNKFTLGDITNSETISGKAILKTKEGYVRKDSEAFGGNLAMSHQWRTINATLTGNGISNLAYITTIDRYTYSENKVNGSYIKSIKNSGIISGNVDATTGSGATQTTIRASVTGNGISSAAYSNNFVKSLTEATIDKIENNGIISGRLKAEVGNNTARGFHEYSNAIITGSANGVSVYSRSSNGQMKNSRAVIGELSNSGSISGNLYARAGSGYGEVKSDVKSSGNGVAIYTESSTKKETKIGSIDNKGMITGKAVIYGGKDKKAMEDKTLRDKIFHVPLTNNIAGYSLPDEDVEDDKKAVAEMRKYEKEMANELENKIEKYKKQIENKEKDILDKTPKKPEISETDKKDRDNTFKKYLKDEIREQENLIWSGYNDKVVADARKRKAELEKLESSSTNDEKIKFLEEYKKILEKRLEESGDPAWKKQEKRNKIAKINNILDKNKVKDIPDSPEILALKKEKAELEKELAKVMDEKNKSDHIAANIHTETGVVASGNGISINDGKEDGVVLGSLKNSGVISGETEIHHGNSQRKYSRIAHKNSGAGIAVGGNVEGKIENTGIISGTEFALLAKGKRNDAYGLDKENVTYESGFKGGVDNYGILAGRIIIGGYQSAHTGSHGEWGAIEEDYAYFETIYKDEKHYNNKGIFLVLDRNGEVKKVIGKNEDATHNGRTVKNVLDKDGTYEGDTTNKIINGVGKDGVIVAKENQNKNIENSIVNGFKNAIKVEKNGLVKISNSTINANGFGKSYAILGDEGANEVEITNKSIINGKIDLGAGDDRLTLSGNYRLNREVDLGKGNNTLAFGKKENIIRSTSSYSTFGTSSTNTSVFNGTVNNANKVEVNENTAFSSSSRINGVNELNLANGKTLDYYFVDKENQAFAELAKSNRNLKVNGSGKVNLVPIGNKVQIGYEKDLLGFSFGNNLLKPNNNGGTTPPSNNGRVAPPNNNPGNNTPGNRGGFFIDPRLTPFDRYSKGAFDAYIADYKLTGIDFLKDYKSTQEVFKNYLYNLTNNNPVGYLKDSAIDTVLAYHKTNTNSNFAKKGQITVSGETFNIRNKYYENNKVVSNGASAEISYGTSDNTNIGLNIGGGQSKVKTSNENLKSEVLVLGVNAEYKAKNFSWKNEISYGRIKPKKYSALDTYSLYSQLGYNIPLSETWSLTPKVSVFLSKIKQKEMTVNNIKVAKDDDTFVETTVGTELNKRFIFGNNGINFGLGVDYSMVKDLDDSKAHFVGGSTEFDLRNYDRKNRATAEIKFGYEHISGITATFRIRKNKDITSSGFGLGYKF
>NC_021281.1|WP_008694438.1|327288_327774_+|cytidine/deoxycytidylate-deaminase-family-protein
MRENYINWDSYFMGIAILSSMRSKDPNTQVGACIVNEDKRIVGVGYNGLPKGCDDKEFPWERDGEFLNTKYPYVCHAELNAILNSIKSLKNCTIYVALFPCHECTKAIIQSGIKEIVYLSDKYTDTDSNRASKKMLDSAGVKYRRFEPDIEKLEINFANIE

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Crispr_ID: NC_021281_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021281_3

712046-712125

Orphan

Consensus_repeat	Method
GAGCAGTATAATCAAAAGAAATACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021281_3

>merge|NC_021281|3|712046-712125|CRISPRCasFinder
GAGCAGTATAATCAAAAGAAATACACGGGGTTTGATGATATGTTCGTAGTGTAGCGAACAGTATAATCAAAAGAAATACA

>NC_021281|3|3|712046-712125|CRISPRCasFinder
GAGCAGTATAATCAAAAGAAATACA	CGGGGTTTGATGATATGTTCGTAGTGTAGC
GAACAGTATAATCAAAAGAAATACA

Protein	Signature genes	Signature genes Name	Protein_function
NC_021281.1\|WP_008700029.1\|718150_718699_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|223813
NC_021281.1\|WP_016339710.1\|703600_704464_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NC_021281.1\|WP_008798039.1\|710963_711440_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341212
NC_021281.1\|WP_008798036.1\|714901_715975_+\|peptide-chain-release-factor-1	unknown	unknown	gnl\|CDD\|234801
NC_021281.1\|WP_008700011.1\|710381_710648_-\|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	unknown	unknown	gnl\|CDD\|274102
NC_021281.1\|WP_008798040.1\|710115_710382_-\|Txe/YoeB-family-addiction-module-toxin	unknown	unknown	gnl\|CDD\|284238
NC_021281.1\|WP_005909561.1\|714431_714878_+\|hypothetical-protein	unknown	unknown	unknown
NC_021281.1\|WP_008798033.1\|719120_720014_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NC_021281.1\|WP_005909577.1\|709086_710061_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|236898
NC_021281.1\|WP_005909581.1\|704646_706173_+\|diguanylate-phosphodiesterase	unknown	unknown	gnl\|CDD\|173864
NC_021281.1\|WP_008795848.1\|713018_713303_+\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|224775
NC_021281.1\|WP_005909578.1\|708086_709094_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_021281.1\|WP_008798038.1\|711828_711957_+\|hypothetical-protein	unknown	unknown	unknown
NC_021281.1\|WP_005899316.1\|718906_719119_+\|exodeoxyribonuclease-VII-small-subunit	unknown	unknown	gnl\|CDD\|224636
NC_021281.1\|WP_008798035.1\|715974_717126_+\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|236467
NC_021281.1\|WP_005909580.1\|706262_707189_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_021281.1\|WP_016339711.1\|717106_718138_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl\|CDD\|234666
NC_021281.1\|WP_008798037.1\|712187_712610_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341213
NC_021281.1\|WP_008692842.1\|707198_708068_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_021281.1\|WP_008692753.1\|713397_714426_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|223929

Protein	Function_ID	Function_description	E-value
NC_021281.1\|WP_008700029.1\|718150_718699_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|223813	COG0742, COG0742, N6-adenine-specific methylase [DNA replication, recombination, and repair].	4.40492e-76
NC_021281.1\|WP_016339710.1\|703600_704464_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	3.6702e-16
NC_021281.1\|WP_005909578.1\|708086_709094_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.54508e-179
NC_021281.1\|WP_008798036.1\|714901_715975_+\|peptide-chain-release-factor-1	gnl\|CDD\|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0
NC_021281.1\|WP_008700011.1\|710381_710648_-\|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	gnl\|CDD\|274102	TIGR02384, Putative_antitoxin_RelB, addiction module antitoxin, RelB/DinJ family. Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other].	2.11785e-12
NC_021281.1\|WP_008798040.1\|710115_710382_-\|Txe/YoeB-family-addiction-module-toxin	gnl\|CDD\|284238	pfam06769, YoeB_toxin, YoeB-like toxin of bacterial type II toxin-antitoxin system. YoeB_toxin is a family of bacterial toxins that forms one component of the type II toxin-antitoxin system in E. coli whose antitoxin is represented by YefM, found in pfam02604. The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair. When the plasmid is lost, the antitoxin is degraded relatively quickly by host enzymes. This allows the toxin to interact with its intracellular target, thus killing the cell or impeding cell growth. These toxins are highly potent protein synthesis inhibitors, specifically blocking the initiation of translation. In the case of YoeB, it binds to the 50 S ribosomal subunit in 70 S ribosomes and interacts with the A site leading to mRNA cleavage at this site. As a result, the 3'-end portion of the mRNA is released from ribosomes, and translation initiation is effectively inhibited.	1.09145e-34
NC_021281.1\|WP_008798033.1\|719120_720014_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	2.71663e-81
NC_021281.1\|WP_005909577.1\|709086_710061_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|236898	PRK11308, dppF, dipeptide transporter ATP-binding subunit; Provisional.	1.16293e-141
NC_021281.1\|WP_005909581.1\|704646_706173_+\|diguanylate-phosphodiesterase	gnl\|CDD\|173864	cd08499, PBP2_Ylib_like, The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding component of an uncharacterized ATP-binding cassette (ABC)-type peptide transport system YliB. Although the ligand specificity of Ylib protein is not known, it shares significant sequence similarity to the ABC-type dipeptide and oligopeptide binding proteins. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_021281.1\|WP_008795848.1\|713018_713303_+\|preprotein-translocase-subunit-YajC	gnl\|CDD\|224775	COG1862, YajC, Preprotein translocase subunit YajC [Intracellular trafficking and secretion].	1.18354e-28
NC_021281.1\|WP_008798039.1\|710963_711440_-\|hypothetical-protein	gnl\|CDD\|341212	cd17492, toxin_CptN, type III toxin-antitoxin system toxin CptN and similar proteins. CptN-like toxin component of a type III toxin-antitoxin (TA) system, which consists of a ribonuclease (RNase) toxin that processes its structured and specific cognate RNA antitoxin, which in turn then directly inhibits the toxin. TA systems have been associated with many important phenotypes, like phage resistance, maintenance of genomic islands, and formation of bacterial persister cells.	4.63619e-39
NC_021281.1\|WP_016339711.1\|717106_718138_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0
NC_021281.1\|WP_005899316.1\|718906_719119_+\|exodeoxyribonuclease-VII-small-subunit	gnl\|CDD\|224636	COG1722, XseB, Exonuclease VII small subunit [DNA replication, recombination, and repair].	3.65101e-12
NC_021281.1\|WP_008798035.1\|715974_717126_+\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl\|CDD\|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	7.61112e-112
NC_021281.1\|WP_005909580.1\|706262_707189_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.8151e-136
NC_021281.1\|WP_008798037.1\|712187_712610_+\|hypothetical-protein	gnl\|CDD\|341213	cd17493, toxin_TenpN, type III toxin-antitoxin system toxin TenpN and similar proteins. TenpN-like toxin component of a type III toxin-antitoxin (TA) system, which consists of a ribonuclease (RNase) toxin that processes its structured and specific cognate RNA antitoxin, which in turn then directly inhibits the toxin. TA systems have been associated with many important phenotypes, like phage resistance, maintenance of genomic islands, and formation of bacterial persister cells.	3.06408e-33
NC_021281.1\|WP_008692842.1\|707198_708068_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.1247e-113
NC_021281.1\|WP_008692753.1\|713397_714426_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|223929	COG0860, AmiC, N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane].	1.22422e-63

>NC_021281.1|WP_008798038.1|711828_711957_+|hypothetical-protein
MVNAEVNKEIIIKMIGHKRYKTTLDIYVYKNYDDMKKAINQI
>NC_021281.1|WP_008798039.1|710963_711440_-|hypothetical-protein
MEINGIYFAKGEFYQIIRDTGGVWNDSKERPLVCLLKIDDTDIYWAIPMGNLNHRNEKAKERLDFYLNIEESDIRSCFYHIGKTTTDTIFFISDVIPIKEIYIDREYLGFNNIHYVIKNKKLISELERKLKRILYFEDSRPNYFRQHITDLKNKLLSE
>NC_021281.1|WP_008700011.1|710381_710648_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin
MSMKLINIRMDEDLKKEMEIVCNDLGINITTAFTIFAKKLTREKRIPFSVSIDPFYSNENIAALQNSIDEVKDGKVIMKTIEELEAME
>NC_021281.1|WP_008798040.1|710115_710382_-|Txe/YoeB-family-addiction-module-toxin
MKISFSIQAWEEYLYFQSQDKKTLKKINELIKDVERNGVLNGIGKPEKLTNNLSGLYSRRINDKDRLVYKLENDFIVILQCKGHYNDN
>NC_021281.1|WP_005909577.1|709086_710061_+|ATP-binding-cassette-domain-containing-protein
MSKVLLEVKNLKKYFQTPKGQLHAVDNVNFAIEEGKTLGVVGESGCGKSTTGRTILRLLEATDGEILFEGKNIRKYSKAEMKKLREKMQIIFQDPFASLNPRMTVSEIIAEPLIIHKKCKNKQELNNRVKELMDTVGLSQRLVNTYPHELDGGRRQRIGIAKALALNPKFIVCDEPVSALDVSIQAQVLNLMKDLQEKLGLTYMFITHDLSVVKYFSNDIAVMYLGELVEKAPSKDLFKNPIHPYTKALLSAIPTINIRKKMERIKLEGEITSPINPGIGCRFAKRCIYAEEICSKESPKLEKVGEAHFFACHRAKELGFVNEK
>NC_021281.1|WP_005909578.1|708086_709094_+|ABC-transporter-ATP-binding-protein
MENRNLLEIRDLEIQYVKDDETVHAVNGISIDIAEGETLGLVGETGAGKTTTALGIMRLITGPTGKIKSGAIEFNGKSILEISEEEIRKIRGNDISMIFQDPMTSLNPVMTVGEQIAEVIEIHEHVTKEEAMNKAAEMLELVGIPGTRKNDYPHQFSGGMKQRVVIAIALACNPKLLIADEPTTALDVTIQAQVLDLMTDLKNKFKTSMLLITHDLGVVAQVCDKVAIMYAGEIVEYGTLEDVFENPKHPYTLGLFGSIPSLDEEKTRLVPIKGLMPDPTNLPTGCKFNPRCPHAVELCSQRTPVVTEVSKGHKVQCLIAEGLVKFRENWEEENE
>NC_021281.1|WP_008692842.1|707198_708068_+|ABC-transporter-permease
MEKTKNKKQSQWAEVFRMLKKNRMAMLGLIILVILVLLALFADVIANYDAVVIKQNLAERLMPPNGEHWLGTDEFGRDIFARLIHGARVSLKVGILAISISVIVGGILGAISGYFGGVIDNIIMRIVDIFLAVPSILLAIAIVSALGPSMLNLMISISVSYVPNFARIVRASVLSIRDQEFIEAAKAIGASNSRIIMKHIIPNSLAPVIVQGTLGVAGAILSTAGLSFIGLGIQPPAPEWGSMLSGGRQYLRYAWWVTTFPGVAIMITILSLNLLGDGLRDALDPRLKQ
>NC_021281.1|WP_005909580.1|706262_707189_+|ABC-transporter-permease
MYKYILKRLVLLIPVMLGVTLLVFAIMYLTPGDPAQLILGESAPKEAVAALREKMGLNDPFFMQYFRFIKNALMGDFGRSYTTGREVFSEIFARFPNTVVLAVLGILISILIGIPVGIISATKQYSLVDSFSMVLALLGVSMPVFWLGLMLILLFSVKLGIFPSGGFDGFSSVILPSVALGVGSAATVTRMTRSSMLEVIRQDYIRTARAKGVAEKAVINKHALKNALIPIITVVGLQFGSLLGGAVLTESVFSWPGVGRLMVDAIRQKDTPTVLASVVFLAVVYSVVNLLVDLLYAFVDPRIKSQYK
>NC_021281.1|WP_005909581.1|704646_706173_+|diguanylate-phosphodiesterase
MKKKFWLLVAMVLSVLFLVACGGDPDKKSGSATAKDTLVIAQGADAKSLDPHASNDNPSSRIRIQIFDRLMDLDDNGVPQPMLAESWERPDDTTIIFHLRKGVKFHNGDEMKASDVKFSLERALKSPEVSHILDGVKGVEVLDDYTVKVTTEKPMAAILNNLSHTTIAILSEKATTEAGDSFGQNPVGTGPYKFVSWQSGDRVTLEAFPDYWQGEAPVKNVVFRNIVEETNRTIGLETGELDIIYDIQGMDKNKLKDDERFNLIEGPQLSLTYLGFNMKKAPYDNPKVREAISYAIDQKPIIDTVFLGAGEPANSILGPNVFAYYDVEKFTQDIAKAKALLAEAGYPNGFKAKIWVNDNPVRRDTAVILQDQLKQIGIDLTIETVEWGAFLDGTARGDHEMYLLGWGNVTRDPDYGMFELISTSTMGAAGNRSFYSNPEVDKLLEAGKTELDPEKRKEIYKQIQEIVRKDLPMYMIVYPLQNVVTQKNIKNFKLDPAQGHKIYGVTKE
>NC_021281.1|WP_016339710.1|703600_704464_+|DMT-family-transporter
MMISDKTKGVFWMLISVLGFTFMGIAVKYLPRIPTYEKVFFRNSVSFILSAYILYRQKESIKVAKENIPFVFGRSFFGFVGMVANFYALENLTMAEANMLNKLSPVFVTICACIFLKEKVDKKQVIGIILMLMAVVFVIKPSFSPEVIPSLVGLFSAILAGFSYTIIRYLNGKVKSEINVFYFSLLSVICTFPLMMMNFVKPNLFEVFMLIVGIGVSAAMGQFGLTYAYTFAPASEVSIYNYVIIITSMFMDYILFSTIPDLFSFIGGFIIITTAIYLYLHNKKKTE
>NC_021281.1|WP_008798037.1|712187_712610_+|hypothetical-protein
MEFYLLTKKFYEKYSNCKEILKKENRPYTICIIEINKLTFAIPIRHNINHKYSIKTFNNQGLDFTKAVIIIDKAFISEKNVYIEQEEYEELSTKKSLIKPKLKKFIKAYKKAIKNPDDLKNKILCEFSSLQYFHKELGIE
>NC_021281.1|WP_008795848.1|713018_713303_+|preprotein-translocase-subunit-YajC
MQELFSKYGNVVIIVVVWIAIFYFLIIRPNKKKQQQQQNLLNSLKEGTEVITIGGIKGTIAFVGEDYVEIRVDKGVKLTFRKSAIANVINNNQQ
>NC_021281.1|WP_008692753.1|713397_714426_+|N-acetylmuramoyl-L-alanine-amidase
MKKKLLSVFFFFLVSVLSFSAKVSDVKFSANKFIINLNAADGECLVSADEESRLIYIEIQNLDSSSFEKFSRNLELDIRSSNLFEDVIIDKSKDSVSLTLQVAPKVSYTMDTTNKRIELNLQRTSKNKHLIVIDPGHGGKDPGAARGSVVEKKIVLAVGTYLRDELSKDFNVIMTRDSDFFVVLSERPKIGNKNKAALFVSVHANASDNKSANGVEVFYFSKKSSPYAERIANFENSIGEKYGDSSDKIIQISGELAYKKNQENSIRLAKKIVENIADRLEMRNGGVHGANFAVLRGFNGTGVLIELGFVSNSYDSEILVDSNSQQKMAEEIAKSIREYLTR
>NC_021281.1|WP_005909561.1|714431_714878_+|hypothetical-protein
MNKNIKMIDLKKLKKINVTVLLLVIVAILGIITLLMPSKDKIGEIEVRKVEQKKEEMVEVTVYGVTEGSDSPSKYTLTLKEASTSDLLKSAVEDMVKKYSSDLELVNIYFSDDTVYYEFNKKDLSEAFLNALQMTTQEITGVEEINLL
>NC_021281.1|WP_008798036.1|714901_715975_+|peptide-chain-release-factor-1
MFDKLEEVVARYDELNKMLVSPEILADSKKMIECNKALNEITEIVEKYKEYKKYVDDIEFIKESFKTEKDPDMKEMLNEELKEAEEKLPKLEEELKILLLPKDKNDDKNVIVEIRAGAGGDEAALFAADLFRMYSRYAERKKWKIEIIEKQDGELGGIKEIAFTIIGLGAYSRLKFESGVHRVQRVPKTEASGRIHTSTATVAVLPEVEDVQEVIVDPKDLKIDTYRSGGAGGQHVNMTDSAVRITHLPTGIVVQCQDERSQLKNREKAMKHLLTKLYEMEQEKQRSEVESERRLQVGTGDRAEKIRTYNFPDGRITDHRIKLTVHQLEAFLDGDIDEMIDALITFHQAELLSASEQ
>NC_021281.1|WP_008798035.1|715974_717126_+|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MNLVEILKFTEEYLKKYSFSKPRLEAEKLVSYVLNLDRIALYIHYERELSEDEKTSIKQYLKKMVEENKTFDELKGKKKDFKEENLDIFNKSVEYLKKNRVPSPLLDTEYIFSDVLKVNKNTLKYSMSREIKEEDKDKIREMLVLRAKKRKPLQYILGEWEFYGLPFKVNEGVLIPRADTEILVEQCIQLMREVEEPNILDIGSGSGAISIAIANELKSSSVTGIDINEKAIELAIENKTLNKIENVNFIESNLFEKLDKDFKYDLIVSNPPYISKEEYETLMPEVKNYEPQNALTDLGDGLYFYREISKLAGEYLKDTGYLAYEIGYNQAKDVTKILQNNNFDILSVIKDYGGNDRVVIAKKAVKTENFEEIEEEEDVNLSE
>NC_021281.1|WP_016339711.1|717106_718138_+|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MSTYLSDYDYFLPEELIGQKPREPRDSAKLMLINRKTGSIEHKHFYNIVDYLQKGDVLVRNATKVIPARIFGHKDTGGVLEILLVKRISLDTWECLLKPAKKLKLGQKLYIGENKELIAELLEIKEDGNRILKFYHEGSFEEILDKLGSMPLPPYITRKLENKDRYQTVYAQRGESVAAPTAGLHFTEELLKKILDKGVEIVDIFLEVGLGTFRPVQTVNVLEHKMHEESFEISEKAAKIINEAKTEGRRIISVGTTATRALESSVDENGKLIAQKKDTGIFIYPGYKFKIVDALITNFHLPKSTLLMLVSAFYDREKMLEIYNLAVKEKYHFFSFGDSMFIY
>NC_021281.1|WP_008700029.1|718150_718699_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MRIIAGEAKNRIIKTRKGFDTRPTLESVKESLFSIITPYIEGSVFLDLFSGSGSISLEAISRGAKRAVMIEKDGEALKYIIENIDNLGFSDRCRAYKNDVIRAIEILGRKNEKFDIIFMDPPYQDNVTKKVLKAIDKANILAEDGLIICEHHLLEDLEDNIASFRKTDERKYNKKILTFYTK
>NC_021281.1|WP_005899316.1|718906_719119_+|exodeoxyribonuclease-VII-small-subunit
MGKNTFEENLENLDKIIESLESGELSLDDAIKEYENAMKLIKSSSKILNEAEGKLLKVIEKNGEIDIEEI
>NC_021281.1|WP_008798033.1|719120_720014_+|polyprenyl-synthetase-family-protein
MNDFQVYLKEKTDFFETELKKELKELSYPETIANGMEYAILNGGKRLRPFLLFVTLELLNEDIKKGVKSAIALEMIHSYSLVHDDLPALDNDDYRRGKLTTHKVFGEAEGILIGDSLLTYAFYVLSQKNLELLSSKQIVNIISKTSEYAGINGMIGGQMIDIESENKKIDLETLKYIHSHKTGKLIKLSIEIACIIANVEKDKREVLEEYADLIGLAFQVKDDILDVEGTFEDLGKPVGSDVDLHKATYPSILGMEESKKILNNTVEKAKQIIKNKFGEEKGKILISLADFIKDRKK

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Crispr_ID: NC_021281_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021281_4

1858245-1858431

Orphan

Consensus_repeat	Method
TCTCCTAACATACCTGCTGATGTTTCTTTTTCTGTTGTTATAG	PILER-CR

2 spacers

The CRISPR arrays of NC_021281_4

>merge|NC_021281|4|1858245-1858431|PILER-CR
TCTGCTAAAATTCCTGCTGATGTTTCTTTTTCTGTTGTTATAGTTCCTTTATTTGTTGCTATTGAATTTCCATTCTTAACATACATACCTGCTGATGTTTCTTCTTTTGTTGTTATAGAATTATCATTTTCAACGTTAGCTTTATCTCCTAACATACCTGCTGATGTTTTCTTTTCTGTTGTTATAG

>NC_021281|4|2|1858245-1858431|PILER-CR
TCTGCTAAAATTCCTGCTGATGTTTCTTTTTCTGTTGTTATAG	TTCCTTTATTTGTTGCTATTGAATTTCCATTCTTAACAT
ACATACCTGCTGATGTTTCTTCTTTTGTTGTTATAGAATTATC	ATTTTCAACGTTAGCTTTATCTCCTA
ACATACCTGCTGATGTTTTCTTTTCTGTTGTTATAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021281.1\|WP_008693181.1\|1871677_1872742_-\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|340818
NC_021281.1\|WP_008798603.1\|1874047_1875133_-\|phospho-N-acetylmuramoyl-pentapeptide--transferase	unknown	unknown	gnl\|CDD\|234638
NC_021281.1\|WP_005910734.1\|1863848_1865267_-\|membrane-protein	unknown	unknown	gnl\|CDD\|225532
NC_021281.1\|WP_008798592.1\|1847026_1847611_-\|hypothetical-protein	unknown	unknown	unknown
NC_021281.1\|WP_032839841.1\|1847628_1848219_-\|hypothetical-protein	unknown	unknown	unknown
NC_021281.1\|WP_016340023.1\|1870290_1871673_-\|UDP-N-acetylmuramate--L-alanine-ligase	unknown	unknown	gnl\|CDD\|223844
NC_021281.1\|WP_008798594.1\|1848205_1849759_-\|toxin-antitoxin-system-YwqK-family-antitoxin	unknown	unknown	gnl\|CDD\|225405
NC_021281.1\|WP_005910732.1\|1865419_1866502_-\|cell-division-protein-FtsZ	unknown	unknown	gnl\|CDD\|236468
NC_021281.1\|WP_008798599.1\|1867852_1868560_-\|cell-division-protein-FtsQ/DivIB	unknown	unknown	gnl\|CDD\|224505
NC_021281.1\|WP_187146772.1\|1849879_1850981_-\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NC_021281.1\|WP_008798600.1\|1868572_1869436_-\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234948
NC_021281.1\|WP_016340022.1\|1851402_1852161_-\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|238635
NC_021281.1\|WP_005905253.1\|1869448_1870294_-\|UDP-N-acetylmuramate-dehydrogenase	unknown	unknown	gnl\|CDD\|223882
NC_021281.1\|WP_005910730.1\|1866524_1867856_-\|cell-division-protein-FtsA	unknown	unknown	gnl\|CDD\|223918
NC_021281.1\|WP_005910750.1\|1842537_1843062_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236892
NC_021281.1\|WP_008798602.1\|1872749_1874048_-\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	unknown	unknown	gnl\|CDD\|223842
NC_021281.1\|WP_016340020.1\|1843137_1844202_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481
NC_021281.1\|WP_016340021.1\|1845414_1846947_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
NC_021281.1\|WP_005910744.1\|1844285_1845263_+\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
NC_021281.1\|WP_008798596.1\|1851037_1851406_-\|holo-ACP-synthase	unknown	unknown	gnl\|CDD\|223807

Protein	Function_ID	Function_description	E-value
NC_021281.1\|WP_008798603.1\|1874047_1875133_-\|phospho-N-acetylmuramoyl-pentapeptide--transferase	gnl\|CDD\|234638	PRK00108, mraY, phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional.	6.03375e-149
NC_021281.1\|WP_008798596.1\|1851037_1851406_-\|holo-ACP-synthase	gnl\|CDD\|223807	COG0736, AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism].	1.50464e-42
NC_021281.1\|WP_008798599.1\|1867852_1868560_-\|cell-division-protein-FtsQ/DivIB	gnl\|CDD\|224505	COG1589, FtsQ, Cell division septal protein [Cell envelope biogenesis, outer membrane].	1.02101e-13
NC_021281.1\|WP_008693181.1\|1871677_1872742_-\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	gnl\|CDD\|340818	cd03785, GT28_MurG, undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	1.06647e-115
NC_021281.1\|WP_016340023.1\|1870290_1871673_-\|UDP-N-acetylmuramate--L-alanine-ligase	gnl\|CDD\|223844	COG0773, MurC, UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane].	0
NC_021281.1\|WP_008798594.1\|1848205_1849759_-\|toxin-antitoxin-system-YwqK-family-antitoxin	gnl\|CDD\|225405	COG2849, COG2849, Uncharacterized protein conserved in bacteria [Function unknown].	5.28834e-31
NC_021281.1\|WP_005910750.1\|1842537_1843062_+\|hypothetical-protein	gnl\|CDD\|236892	PRK11281, PRK11281, mechanosensitive channel MscK.	0.00958101
NC_021281.1\|WP_005905253.1\|1869448_1870294_-\|UDP-N-acetylmuramate-dehydrogenase	gnl\|CDD\|223882	COG0812, MurB, UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane].	6.59864e-116
NC_021281.1\|WP_187146772.1\|1849879_1850981_-\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_021281.1\|WP_008798600.1\|1868572_1869436_-\|D-alanine--D-alanine-ligase	gnl\|CDD\|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	4.54729e-115
NC_021281.1\|WP_016340022.1\|1851402_1852161_-\|TatD-family-hydrolase	gnl\|CDD\|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	1.45418e-116
NC_021281.1\|WP_005910732.1\|1865419_1866502_-\|cell-division-protein-FtsZ	gnl\|CDD\|236468	PRK09330, PRK09330, cell division protein FtsZ; Validated.	8.98114e-168
NC_021281.1\|WP_005910730.1\|1866524_1867856_-\|cell-division-protein-FtsA	gnl\|CDD\|223918	COG0849, ftsA, Cell division ATPase FtsA [Cell division and chromosome partitioning].	3.74988e-94
NC_021281.1\|WP_008798602.1\|1872749_1874048_-\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	gnl\|CDD\|223842	COG0771, MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane].	9.23273e-153
NC_021281.1\|WP_016340020.1\|1843137_1844202_+\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	2.26699e-135
NC_021281.1\|WP_016340021.1\|1845414_1846947_-\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
NC_021281.1\|WP_005910744.1\|1844285_1845263_+\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	4.87759e-175
NC_021281.1\|WP_005910734.1\|1863848_1865267_-\|membrane-protein	gnl\|CDD\|225532	COG2985, COG2985, Predicted permease [General function prediction only].	1.11125e-134

>NC_021281.1|WP_016340022.1|1851402_1852161_-|TatD-family-hydrolase
MKIIDSHVHLNLEQFDNDREEVFKRIEEKLDFVVNIGFDLESSEKSVEYVDKYPFIYAVIGFHPDEIEGYSDEAEKKLEELSKNPKVLAIGEIGLDYHWMTRPKEEQWKIFRKQLELARRVNKPVVIHTREAMEDTINILNEFPDIKGILHCYPGSVETAKRMIDRFYLGIGGVLTFKNAKKLVDVVREIPIEKLVIETDCPYMAPTPYRGQRNEPIYTEEVAKKISELKNMSYEDVVRITNENTRKVFKML
>NC_021281.1|WP_008798596.1|1851037_1851406_-|holo-ACP-synthase
MIVGIGNDIIEIERIEKAISKESFKDKIYTQRELENIKKRGNRAETYAGVFSAKEAISKAIGTGVREFSLTDLEILNDDLGKPYVVVSEKLDKIIKSKKKDYQIEISISHSKKYATAMAIIF
>NC_021281.1|WP_187146772.1|1849879_1850981_-|peptide-chain-release-factor-2
MDILEIKREFLEMKEKAENIRRSLDLEKRKSTIKELEKLTFEENFWSDKRKSSEIIKNMNFEKNIVSRYEKLATEIEDEEVLIDFVESGETSFESELSEKHKILKNDVEEFEINLLLDGEYDMNNAIVTIHSGAGGTEACDWADMLYRMYLRWCNLRNYKVTELDFMEGDSVGVKSVTFLVEGINAYGYLKSEKGVHRLVRISPFDANKKRHTSFASVEVVPEVDENVEVEIDPADIRIDTYRASGAGGQHVNMTDSAVRITHFPSGIVVTCQKERSQLSNRETAMKMLKSKLLELEIKKKEEEMKKIQGEQSDIGWGNQIRSYVFQPYALVKDHRTNTEIGNVKAVMDGSIDDFINSYLRWIKSN
>NC_021281.1|WP_008798594.1|1848205_1849759_-|toxin-antitoxin-system-YwqK-family-antitoxin
MKKVLNILLIALILTILWILFLVMKPSSSDVQGIKSVKTKYDKYYAEIDKKIESEFDKNPQKLYEERRNSLRRLNLNLGFNRVVKYLGDDKYIFGFTRNGKLIFVLKKDKPDSDNGVVKYLYDNQSLKEIGYVEGKNFDFSGKVQFFDEEGILRNEYQYYKGKLEGLEKVFSEDGKLEEERVYKNNLIDGEEVYYYENGKVAEKGQYVAGKRNGLSVDYYESGKLYSERTYKNDLLNGNYKIYYENGETKEEAYLKNDKLEGISKIYYESGKIHQIAHNKNDKKNGSLVVYYENGKPEREMNFKNDILDGFEISYYESGKVKTRIFHKNGKPQGEGLSFYESSKLKEKGYYKDGILDGQYIMYYEDGKLQEVYNYIAGILNGEYKLYYENGKLQENGNYIDNNLEGKVSMYYESGKLEWEYNYIKGKLEGEYKNYYENGKLERTGNYKNGLLEGEAVFYLEGGQIGEKASFLNGKEEGDHLYYDKTGKLIKKEVYSNGNLLSTEEFQKVEEDNDERN
>NC_021281.1|WP_032839841.1|1847628_1848219_-|hypothetical-protein
MKEIRVKPLEADNKEGKIMAYIFLFQPILCIIVAIFMIFIIKTQEENLRFLVALGIFILLAVFSFFKNISDIANGVLAEEVCYIENKIFCYTKTRNFLGIKKVIKSFQIPIAEISDVRENEKKIRMNMFSLFKPRNSVEIETREGKKYSIMNDFHLSGKHSQDDMKIETREERAKRIFNEVKELVMEAKNMNTFNF
>NC_021281.1|WP_008798592.1|1847026_1847611_-|hypothetical-protein
MKVKELKINPVPEKKSLRFVVHWLMMMPILPFIFLGIIYYVIDKKILNDLYQQVLENKGYFCIFVFYWLFAAINLAREIFSYLLVEEVCYVENKVFYYQKFRIAFGMRKLMKKLEIPLSEILEVKEGKKPFFLCFLYSIITHRNAVEIKTRDGKKYEIMNSIVFGDKDSQSPTSSETNERANKIYNEVKNMILK
>NC_021281.1|WP_016340021.1|1845414_1846947_-|glutamate--tRNA-ligase
MCDNCKKRVRTRVAPSPTGDPHVGTAYIALFNIAFAHVNGGDFILRIEDTDRNRYTAGSEQMIFDALKWLDLNYSEGPDVGGDYGPYRQSERFDLYGKYAKELVEKGGAYYCFCDHERLENLRERQKAMGLPPGYDGHCRSLSKEEIEEKLKAGVPYVIRLKMPYEGETVIHDRLRGDVVFENSKIDDQVLLKADGYPTYHLANIVDDHLMGITHVIRAEEWIPSTPKHIQLYKAFGWEAPEFIHMPLLRNNDRSKISKRKNPVSLIWYKEEGYLKEGLVNFLGLMGYSYGDGQEIFTLQEFKDNFNIDKVTLGGPVFDLVKLGWVNNQHMKLKDLGELTRLTIPFFVNEGYLTNENVSEKEFETLKKIVEIEREGAKTLKELAKNSKFFFVDEFSLPEVKEDMDKKERKSVERLLNSLKDEVGLKSIKLFIEKLEKWESNEFTAEQAKDLLHSLLDDLQEGPGKIFMPLRAVLTGATKGADLYNILYVIGKERALKRIKDTVKKYNIAI
>NC_021281.1|WP_005910744.1|1844285_1845263_+|tryptophan--tRNA-ligase
MKRSLSGIQPSGILHIGNYFGAMKQFIDLQDDYDGFYFIADYHSLTSLTKAETLKENTYNIVLDYLAIGLDPNKSTIFLQSNVPEHTELTWLLSNITPVGLLERGHSYKDKIAKGIPSNTGLLTYPVLMAADILIYDSDIVPVGKDQKQHLEMTRDIAMKFNQQYEVEFFKLPEPLILDDSAIVPGTDGQKMSKSYNNTINMFATKKKLKEQVMSIVTDSTPLEEPKNPDNNIAKIYALFNNIDKQNELKEKFLAGNFGYGHAKTELLNSILEYFGKAREKREELEKDIDYVKDVLNEGSKKARAIAIEKIKKAKEIVGLIGNIY
>NC_021281.1|WP_016340020.1|1843137_1844202_+|alanine-racemase
MRTWVEIDKENLKYNVLKLKEIANNREVLGVVKANAYGLGSVEITKILQEIGVNFFGVANLEEAIELQEARIKDKILILGASFEDELIEATKRGVHVAISSMGQLQFLVNNKLNPNIHLKFDTGMTRLGFEVDEAKKVIEFCKNNNLNLVGIFSHLSDSDGNTVETKNFTLEQIEKFKKIVNSLNLKYIHISNSAGITNFHNDIVGNLVRMGIGMYSFTGNKKTPYLKNIFTIKSRVLFIKKVKKDSFVSYGRHYTLPADSTYAVLPIGYADGLKKYLSKGGYVLINNHRCEIIGNICMDMTMIRIPKEIENSVKIGDEVTVINADILDNLNIPELCVWEFMTGIGKRVKRIIV
>NC_021281.1|WP_005910750.1|1842537_1843062_+|hypothetical-protein
MNKNKIILFLISLFALTACSSINEYLPSFLTEGSTPAAIQEAVSSRVNPEKEIYVLSSAQLSKSGSIIAQSRANKQASEALRGKVKSEVEAQIRGYLEDMDAFSKSIVSPVFSDLATYSTDLAMKKVTQKGAWEDSEKVYSLLAVDRNEVITITDKVFRNFVDNASKNLGNSTK
>NC_021281.1|WP_005910734.1|1863848_1865267_-|membrane-protein
MHFDVVGFIFNSLVLLFFTMTLGNLFGNVKFRKFNFGITGTLFIGLFVGYFLTKYAVTIPEESKYFSKAQNVLKGNVIDNSIMNLSLLIFIVGTGLLAAKDMKYAITKFGKQFVIIAIFIPFVGAVASYGFSQIFSKMSPYQITGTYTGALTSSAGLAAATESSEAESRHLASEFQGLSEGTKTKILAIINNAKERDAKLKNEDIPEKMTIENTTTLSAEDTEVYVTEAKAGVGVGHSIGYPFGVLFLILGINFIPKIFRFDVEKEKEKYFAQKKIDLSKDKDAGKNTIPEVKMDFVGFSVAAFLGYFLGGIKISMGPLGTFSLGSIGGAIIVALLLGFIGKIGPITFRMDSVVLGKMRTYFLSIFLAGTGLNYGFRVVEAVTGDGIMIAVVSALVAILSVLFGFLLGHYVFHINWTLLSGAITGGMTSAPGLGAAIDALDCDEPAVSYGATQPLATLCMVIFSIIIHKLPI
>NC_021281.1|WP_005910732.1|1865419_1866502_-|cell-division-protein-FtsZ
MTDAIKDLVKIKVIGVGGGGGNAINDMLYSGVTGVEYIAANTDKQDLEKSLADVKLQIGEKLTKGQGAGASPEVGRQAAEEDIEKIQELLKGTDMLFITAGMGGGTGTGAAPVIAKAAKELDVLTVAVVTKPFNFEGERRKNNAESGIELLRQNVDSLVIIPNDKLFDLPDKSITLQNAFKEANNILRIGIKAVVDLVLGQGFINLDFADIKSVLKDSDIAVLGFGDGEGENRAMKAAEKALQSPLLEKSIQGADKILINLMTSQDVGLSESQTVTDVIRQAAGKKIEDVMFGVTIVPEFTDRIEITIIANNFKEGVESNSDSPIKMGTGKAAESSKQTESKEDPDDVFDIPPWMRNNKR
>NC_021281.1|WP_005910730.1|1866524_1867856_-|cell-division-protein-FtsA
MKDDVIKKVALDIGNNGIKLLVGEMSSDFQRISVTNYVKTKSKGISKSLIENPEALAETLREAIGKAESIESPITKLSLALGGPGILSATVNVKSSFPEKEIEKTDMDNLLRQAKRQIFKGREGQYRILYKEVYNKKLDNSGIVRQPIGMVGKELQADIHLVYVDDSYVQKFIQVVNKIGIDIDRIYLNSYASAKGTLDEETKKMGVAHVDIGYGSTSIVILKSGKVLYAKTKPIGEMHYISDLSIMLKIPKEGAEEILKKLKNKQVEADNTIRYGAKKVTLREIKDIILARTGDIINFIGSAIDESGFNGVLAKGIVLTGGAVEIEGVAEQIATRSGYLTRKMLPIPLKGLKDAFYSDAVVIGVFLEDMEREYKASIEETKEANKVKKEKIKEETTSNNKINDKKMDRKEEIDNFLGEIEEVEPEKEEGKIRKVIRWFGELF
>NC_021281.1|WP_008798599.1|1867852_1868560_-|cell-division-protein-FtsQ/DivIB
MGIRLLFLSGIIYLIYMLPQNFFRLDYFNINKVNVTDNSKMLHDELTKLTEKLYNKNSIYIDSNEIKEFIEKDIRVESATVEKKSLGEIDIDVKEKDLAYYAVIGKNIYLTDKEGKIFAYLNEKEVEGVPFIIANNEEEIKEISEFLNEISDLAIFKKISQIYKVNDKEFIIILTDGVKIKTNRAKDNDEISKEKENKRYLIAEQLYFNMSKERKIDYIDLRFNDYIIKYLGDSK
>NC_021281.1|WP_008798600.1|1868572_1869436_-|D-alanine--D-alanine-ligase
MKIAVFMGGTSSEKEISLKSGEAVLESLKKQGYDAYGVVLDERNQVTAFLDNEYDLAYLVLHGGNGENGKIQAVLDILGKKYTGSGVLASAITMDKDKTKQIAQSVGIRVPKAYRTVEEIERFPVIIKPVDEGSSKGVFLCNNREEAEEAVKKLARPIIEDYIVGEELTVGVLNGKALGVLKIIPQADVLYDYDSKYADGGSIHEFPAKIEDKSYKEAMKIAEKVHSEFGMKGISRSDFILSDGELYFLEVNSSPGMTKTSLIPDLATLKGYTFDDVVRITVETFLK
>NC_021281.1|WP_005905253.1|1869448_1870294_-|UDP-N-acetylmuramate-dehydrogenase
MKVFTNQEMKNYSNMRVGGRAKKLIILETKEEIVDVYNDKENTNIFILGNGTNVLFTDDYMDRTFVCTKKLNKIEDLGNNLVKVETGANLKDLTDFMKDKNYTGIESLFGIPGSIGGLVYMNGGAFETEIFDKIVSVEVFDENHQIREVKKENLKVAYRKTEIQDKNWLILSATFKFDNGFDESRVKEIKELRESKHPLDKPSLGSTFKNPKGDFAARLISECGLKGTIIGNAQIAEKHPNFVLNLGGATFKDITDILTLVKKSVFEKFGIKLEEEIIIVK
>NC_021281.1|WP_016340023.1|1870290_1871673_-|UDP-N-acetylmuramate--L-alanine-ligase
MEKIYFIGINGIGMSGLAKIMKCKGYDVKGADICTNYVTEELLSMGITVYNEHDEENVKGSDYVIASTAIKENNPELSYAKNNGITLLKRGELLAKLLNRETGIAVAGTHGKTTTSSMLSAVMLSKDPTIVVGGILPEIKSNARPGKSEYFIAEADESDNSFLFMYPKYSVITNIDADHLDVHGNLDNIKKSFIKFICHTQKEAIICMDCENLRDAVSKLPEGKTVTTYSIKDENANIYAKNIRIVDRKTIFELYINKELIGEFSLNIPGEHNILNSLPVIYLALKFGVSKGEIQETLHNFKGSKRRYDVLFDNDLENGYGNKTKRVRIIDDYAHHPTEIKATLKAIKSIDKSRLVVIFQPHRYSRVHFLLDEFKDAFKDVDKVILLPIYAAGEKNEFNISSEILKEHINHNNVENMNEWKDVKRYVSRVKKDSTYIFMGAGDISTLAHQIAEELEGMSE
>NC_021281.1|WP_008693181.1|1871677_1872742_-|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase
MKKVMLTTGGTGGHIYPALAVADKLKLKGVDTVFVGSTERMEKDLVPDSGHKFIGIDISVPRGWKNIRKYLKAIKVAFKVIKEEKPDAIIGFGNYISVPVIIAGILLRKKIYLQEQNVNIGSANKMFYKIAKMTFLAFDKTYDDIPIKSQSRFKVTGNPLRKEIDGLRYATEREKLGIKPGEKVLLITGGSLGAQEINNIVMKYWEKFCANKNIRIFWATGNNFEQLKKVRKSKKENDRIEPYFNDMLNVMAAADLIVCRAGALTISEIIELEKPSIIIPYGSIKVGQYENAKVLTDYNAAYVFTRDELDDSMKKVFEIIRNDEKLKKMRIRLKPLRKPNAAEEIIASLDIWRN
>NC_021281.1|WP_008798602.1|1872749_1874048_-|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase
MKKAMIYGLGISGTGAKELLEKEGYEIIVVDDKKAMTSDEALNYLDGIEFFIKSPGIPYNNFVKEVQKRKIKILDEIEIAYNYMMEKRMKTKVIAITGTNGKSTTTAKISDMLNYAGYKAAYAGNIGRSLSEVLLKEKDLDFISLELSSFQLENIENFKPYISMIINMGPDHIERYKSFDEYYDTKFNITKNQTEDFYFIENIDDVEIEKRAKQVKAKRISVSKFKKADIFVENDKICHGKDSIIDVDKLSLKGIHNLENTLFMVATAEILKIDREKLKEFLMIATPLEHRTELFFNYGKLKFINDSKATNVDSTKFAIEANKNSILICGGYDKGVDLAPLAEMIKENIKEVYLIGVIADKIESELKKVGYEDSRIHKLVNLENSLQDMKKRFTKDSDEVILLSPATSSYDQFNSFEHRGKVFKELVLKIFG
>NC_021281.1|WP_008798603.1|1874047_1875133_-|phospho-N-acetylmuramoyl-pentapeptide--transferase
MLYFLAEYFTKLEFLKSIYLRAFLAFVVSFFIVLFVGKPFIKYLKVKKFGEEIRDDGPSSHFSKKGTPTMGGVLIIAAVLLTSLFINDLKNPLVLLVLLSTLMFAGIGFIDDYRKFKVSKKGLAGKKKLLFQGIIGLVIWAYIYFVGLTGRPMVDLSLINPISSHQYYIGAIGMFFLIQIVLMGTSNAVNITDGLDGLAIMPMIICSTILGVIAYFTGHTELSSHLHLFYTVGSGELSVFSAAVTGAGLGFLWYNCYPAQIFMGDTGSLTLGGILGVIAIILKQELMLPIMGFIFVLEALSVILQVGSFKLRGKRIFKMAPIHHHFELMGIPESKVTMRFWIGTLIFGIIALGTIKMRGIL

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Crispr_ID: NC_021281_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021281_5

1970958-1971043

Orphan

Consensus_repeat	Method
TCTTCAGGTTTTTCCGTTGCCTGCCAACTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021281_5

>merge|NC_021281|5|1970958-1971043|CRISPRCasFinder
TCTTCAGGTTTTTCCGTTGCCTGCCAACTGTCATAGCCTGTATATCTATGAATCTGTCTTCAGGTTTTTCCGTTGCCTGCCAACTG

>NC_021281|5|4|1970958-1971043|CRISPRCasFinder
TCTTCAGGTTTTTCCGTTGCCTGCCAACTG	TCATAGCCTGTATATCTATGAATCTG
TCTTCAGGTTTTTCCGTTGCCTGCCAACTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021281.1\|WP_008798661.1\|1968442_1968832_-\|hypothetical-protein	unknown	unknown	unknown
NC_021281.1\|WP_005910618.1\|1953179_1954010_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_021281.1\|WP_005910606.1\|1971928_1972312_-\|CidA/LrgA-family-protein	unknown	unknown	gnl\|CDD\|224298
NC_021281.1\|WP_008798668.1\|1982261_1983242_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NC_021281.1\|WP_008798665.1\|1972342_1973314_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NC_021281.1\|WP_005910611.1\|1968847_1969231_-\|hypothetical-protein	unknown	unknown	unknown
NC_021281.1\|WP_016340051.1\|1978104_1979295_-\|ArsA-family-ATPase	unknown	unknown	gnl\|CDD\|223082
NC_021281.1\|WP_008798658.1\|1954288_1955869_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173855
NC_021281.1\|WP_008798660.1\|1957782_1968429_-\|autotransporter-associated-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|380182
NC_021281.1\|WP_005910615.1\|1955880_1956666_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_021281.1\|WP_005910614.1\|1956646_1957633_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226967
NC_021281.1\|WP_005910596.1\|1980101_1982261_+\|LUD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224062
NC_021281.1\|WP_008693323.1\|1973325_1974105_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|224997
NC_021281.1\|WP_016340049.1\|1969967_1970903_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376232
NC_021281.1\|WP_005910598.1\|1979507_1980059_+\|lactate-utilization-protein-C	unknown	unknown	gnl\|CDD\|224473
NC_021281.1\|WP_008798666.1\|1976941_1978108_-\|ArsA-family-ATPase	unknown	unknown	gnl\|CDD\|223082
NC_021281.1\|WP_008798663.1\|1971228_1971936_-\|LrgB-family-protein	unknown	unknown	gnl\|CDD\|224265
NC_021281.1\|WP_005910602.1\|1975285_1976713_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
NC_021281.1\|WP_005910619.1\|1952240_1953179_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_021281.1\|WP_005910610.1\|1969243_1969615_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370466

Protein	Function_ID	Function_description	E-value
NC_021281.1\|WP_005910618.1\|1953179_1954010_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.63672e-89
NC_021281.1\|WP_008798668.1\|1982261_1983242_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	1.01796e-79
NC_021281.1\|WP_008693323.1\|1973325_1974105_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	1.12157e-80
NC_021281.1\|WP_005910615.1\|1955880_1956666_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	7.69353e-123
NC_021281.1\|WP_008798665.1\|1972342_1973314_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	8.39978e-122
NC_021281.1\|WP_005910596.1\|1980101_1982261_+\|LUD-domain-containing-protein	gnl\|CDD\|224062	COG1139, COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion].	0
NC_021281.1\|WP_016340051.1\|1978104_1979295_-\|ArsA-family-ATPase	gnl\|CDD\|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	4.62118e-113
NC_021281.1\|WP_008798658.1\|1954288_1955869_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173855	cd08490, PBP2_NikA_DppA_OppA_like_3, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_021281.1\|WP_008798660.1\|1957782_1968429_-\|autotransporter-associated-N-terminal-domain-containing-protein	gnl\|CDD\|380182	NF033175, fuso_auto_Nterm, autotransporter-associated N-terminal domain-containing protein. This domain typically is found in the genus Fusobacterium, in N-terminal regions of large proteins that are recognized as autotransporter proteins by C-terminal regions matching Pfam model PF03797. In paralogous families of such proteins, the N-terminal and C-terminal regions are fairly well-conserved, but the repetitive central region is poorly conserved in both length and sequence.	3.186e-28
NC_021281.1\|WP_005910606.1\|1971928_1972312_-\|CidA/LrgA-family-protein	gnl\|CDD\|224298	COG1380, COG1380, Putative effector of murein hydrolase LrgA [General function prediction only].	6.72271e-28
NC_021281.1\|WP_005910614.1\|1956646_1957633_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226967	COG4608, AppF, ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism].	1.39e-113
NC_021281.1\|WP_005910610.1\|1969243_1969615_-\|hypothetical-protein	gnl\|CDD\|370466	pfam09403, FadA, Adhesion protein FadA. FadA (Fusobacterium adhesin A) is an adhesin which forms two alpha helices.	5.85685e-19
NC_021281.1\|WP_005910598.1\|1979507_1980059_+\|lactate-utilization-protein-C	gnl\|CDD\|224473	COG1556, COG1556, Uncharacterized conserved protein [Function unknown].	1.21217e-67
NC_021281.1\|WP_008798666.1\|1976941_1978108_-\|ArsA-family-ATPase	gnl\|CDD\|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	1.87937e-109
NC_021281.1\|WP_008798663.1\|1971228_1971936_-\|LrgB-family-protein	gnl\|CDD\|224265	COG1346, LrgB, Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane].	1.36149e-82
NC_021281.1\|WP_005910602.1\|1975285_1976713_-\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	7.85237e-127
NC_021281.1\|WP_005910619.1\|1952240_1953179_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.0367e-116
NC_021281.1\|WP_016340049.1\|1969967_1970903_-\|hypothetical-protein	gnl\|CDD\|376232	pfam18813, PBECR4, phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease4. A predicted endoRNase of the Barnase-EndoU-ColicinE5/D-RelE like nuclease fold found in polyvalent proteins of phages and conjugative elements. The predicted active site contains a conserved histidine residue.	1.45406e-13

>NC_021281.1|WP_016340049.1|1969967_1970903_-|hypothetical-protein
MDSGKIFKKLRLAQKVYDENFLNKEFLYIYENKNEIKKFSITFKKQNFLHLTGIKYDSKDNMNPLDFYRAVKEKRLSLSEKNINDFTNIKLKVFPKLINLLQESSVFYKFSPEKGNTNWLYIDSFITENQRKEESIILGITEKGENTNNYAPSSILRGIPDEKGDYIGNVLIIACRNFSLKKEKYKAIYRVTDVSKIPDELKKDILDLENYNCITGNPIGNIKFKNFENRWIAKIDLERYGIEKKEIDIEGTQISAGFIEEERIYAGVMIYYNISDLIITKEIAQKFVPIKQKEQEKVTEKSKNKRIEIED
>NC_021281.1|WP_005910610.1|1969243_1969615_-|hypothetical-protein
MKKIILTLFVLLSIGIFANDEIISALKGLNAEYEDLVKEEEARFQKEKELSERAAAQNVKLAELKANIEEKLLAAPEERKTKFFKDTFDGLVKDYSKYLSQINEKIAENTEIVSNFEKIQKIR
>NC_021281.1|WP_005910611.1|1968847_1969231_-|hypothetical-protein
MKIKEILLISLSVVSLIACSNNKINNEDRDAMQILEEKREYYEELDKKKAKEAKGYQIEMTAEEVETEKEKLANMTEDEKLKYKVDKAKEKIDNMLDIAKKARQEEIDVEETKNQVEEALKNITEEK
>NC_021281.1|WP_008798661.1|1968442_1968832_-|hypothetical-protein
MKKILLLSLSLLILACTNMDTSTDESKEAQISRLLKEADKKKEETVEVEKTVVTDNGEKITEEETTVQNKKSHKGMTRGEIMEYEMTRVSDEMNALQADVQQYQEKKAQLKAYQEKLQKLEELNNAGIK
>NC_021281.1|WP_008798660.1|1957782_1968429_-|autotransporter-associated-N-terminal-domain-containing-protein
MKDYNKVESCLKSFLKNNKRLSYSMALLISFLINGGFSYADEAIQVPLRTEIKTRIEKEQENISQMLKEADESMKDIELKIKKLTQRGEFWVKPLEKSYQGFIFANWGNYSKNKNKTESNFNGPEYSASYGKNMGYGQFSNGKYYGEYGIVKNPLEFVDKIDFGANITPKAVTEKTIVEKTVIQKIIEAPRVTPPTVTIATITPPTVSTPTIGTMSEPGAVTVNVTAPGTPPTLSAITVSAVPEVSITPQPPEVAEAPVVTEPAVTAPATPAGFTPRLVSPPVVEEKKVNDPRVPNPPALSVTFQDVPDNLTGYNKNATMDNNGLISQLDLLTGTYNMYFKGHGQGQEFSFTGATASSFTPSSGGLTLPGSDSGSYSKVAFYGIGGKASATISENVTMNMIGNYVGGAFNTIFYIGNNSNSGNQTSLLTNKGKVNIYGNKILVVNSDNVGSATGSVMKFVNTGTITSYTESKEFAPGKNSGPGENIIFAGFTYGDNASEHIENGAGGKVEFYTPGSAGWMYSPAASDNVKRSAVNNGTMKLYGKNSLGVGTNERTRINDIAYADIQLNTPIEILGDQSVGASIKIQPSNNSQNFINSTWNIKIGGLDKAQQAGSGDEIYDSKTSTLKAGNTLKVEQSIGLNFDFTHASSGTLREIEVKRYKISLEADADSSTGIRVGHAKINLTDADAFTQIKMNGTNNIGLLADGATSELKYTNTRNALNLDGGEGNILFASINSGKLNVENKFELKTSGGSDETTGAKFVSAYTKGSGSKVTFKKGISFKHTGNESIGMYATDSGDITVTNPTTVTLPTVTAGSEIDNSTLPSVATSPTISTKLSITGSKSVGYYANNGGTIVNTGSSTKVTNGSALAYAKGANSKITISNSLLDYSGEGYSLYTENSGKIVADNSVLVLRGKAVGMKANSVSSGDISFTNGKIVMMSNDAIPFVASDITTTVNASDIRTGLGLPSNIIIAKGKEGGTVFNKYKIAAVDGMANLTIDYDLDKTYATDDNNETSSDNSKKASYALFRRYLIQRAKVEASGKTIKAILNSTDLTKLDATQVVGLEMSSSKNANNVNETAINLVNSKIIADRKDGGTGAVGAYINYGLVNIDATSKIEVEKDTSAGNTANSGAVGVYAVNGSKVDNKGNIEAGGTDSVGILALGYGESGGVAQKNQFGGKTGEGNITVTNSGSVTMANNDAIGIYVKNNNTTTVSTNHKVTNSGTIEVKESASKTAIGIYADKSTVIPKDGTIKIGKKAVGIYADNSAIGSGTDNLGKIDFAGESGVGIYLKGSSSTLTGSDVILKQSTSGTFKGKVGILVARETASTITTEVKTKDGSDTIDDVIAYYSKNNGTLTVQSSFELNKRSVGIYGAVNGSTPENLVYNGSKTMKLGEKSTGIFGKGNISFASGSNIELNGDKSVGVFATESTGIINSEGNLKFSKEKSIGLYGLNGATINDKTASMDFSNANAKNNIGVYLAGAKWNDNRTAAYTFNSNHSKNNIYLFAQGSRINGTDTGSTVTLKNDFQVAPGGSASPVEKTIGMYFDTTVKGGTFAENKVDMTNANAKVSVTNKGIGLYTKAEATSSGKNNIIEKIKVSSTGKDSVGVYNKGNLKLSGTDGLIEAKTNGIGIYGVAGKITVENTHKVEVTAAGTGMYLTGNSYLDGGKLKLENKTVGTPAAGIYYKKGTSSDEVTHNTDLEVVSGSNLLTLYADGGIKLNNTEIIKIGDGTNNVGAFVTGGSIFKNKGGITLTDSIKNAIGIYVEDGQAANESGKNIGVYDYNTSGSGTPSIGMIAKAASGKTAKVINAGNIIADGEAIGMNIENNSEGTNSGTITATDKELSGTNYKSIGAYINGANAKFTNSGTISTENIGLALKDTTANKILNSGTLKLTKSEAVGVYANNSIVDFNIAPTVESTADKTVALYATGNTKIAGQITTAAGKSHVGVYAEGNAEFQSGSKVTVGDGIEHLGTTYYGIGIYTKSGYNKAANVNLKLNGSKTIGFYLGATGSTGSTVTHTGTIDVGSGIGTFIPKYSKFVAQNTTFNVGNEGTAVYLKGGEADLGSTGTANINFTGSGRAVYQDGGTLTTGAGLHITGTGSFLTLKNANSIINSIVNVGENGIGINGIYDSNAQDYTLKLDSPTGHIKLSGNKATGIAAVAKNTVASKKVDIINKGTIETISGEKTTGIYGKGANIENATGAKINIGAKGVGIYTTNYYDNSTLSLTNTTLKNNGEINLTGDEATGIVAVKAHTTQDFIGGKITGTKDKLVGMFFDNSAAQTKVKDFNISLGTNAKGLIFKDGQDFTITSSSTNKVTIGNTTNVASRGIGISALGVNGTVSNTEVKVGKNSLGLYAKDKKLTFDLATGKLESSDASRSSILAYADGNNSEVALNGGGTLKVGANGIALGTKGGKITANATTTVEVDGVKGLGAYVENGGSISNNFDIKVKSAEGIGMYAKGGALASVAKVSELKGNKSIGYVFENITNAINMPNSVQLTDTNATGQVGVAVKGTGAGLTVAGVSVVGSKNIGIYNETTGAVTNNGALNVADSTGDSSIGIYSQGGTVTSTGNATIGKNSIAIYGKNTAATLNGNLNIGEKGVGLYVDNTATSKGDTAVNGNITVGANGAIGIQTTNSKVNLTGDLSVASGDSKGIFSMGAGNVETTGNINVGNNSVGIYKNGSGEIKTALGSIGKTLTVADSGYGVFSKGAKLINNMNITVGVDAIGAYVDGNDLTSTGTVTVADKGVGLLVKGSGKTLTSTGNITVGSNNSVGLYAGDNANIAQSGNITVANNNGIGVYSKGSGNISTVGAMTVGKDSIGVYKDGKGTMNINASSPIQTMTIAEKGYGLYYKGNSRADSIINSNMNMTLGKEAVGIYAKNTTVNHTGDITVGETTIGSSGFTTPSDNKNSIGIFGDNSNINFKGNMLVDKPLSVGIYGANGGSITVKSGSTITVKNGATGIMTGSKVENITLESGSTLNVDGKVDTNVYTNATKSNVSFGIAAYSGLIDNQGTINVTNGATGIYLAGTASLKNGVTGTINIDATSKSTAKPDTKASAELGGIKVTDKGVVTINNKVINGGTLNVKGALNMEGLGLDVSTGKTVVDAKSISGVAEVLPSFSRGNSEQKVTIKDVFRTGVVGAFSGDVKSKSVSWIAKISKEPGSSTTTSDITMVRIPYNSLISGERYKNLASGLEDIRSKIGKDSSSPIFKSLDNISSHRDFARAVANIRGDVYSNIQERMKTVENSFDKSYNELLSSYNKTRNVDKFSVIYTGGEHKDSTLGVSGYEYKSTGVLYLNDREAFTYGGKYGWSAGIVGSNFEFKGDTNKGSKERVISGKLGLHYQAPLNKDDDNARLRWLTRGEITVNNHRTKRYSQVGADTYQNKASFYSTELSWKNIISYDYDINTNWTVKPYTGIDISYGHIFNIKEKNEGLPLEVKGKDYFVITPNVGVETKYVLPLGAVHQAFAKVDTEFSYDVTKLYHGINQAKMRNASTGYYDLSKPERRRGRVAVGAELGLEKENAYGITFRAEYQGYKKSQLNYGVRLNYKF
>NC_021281.1|WP_005910614.1|1956646_1957633_+|ABC-transporter-ATP-binding-protein
MVRDLSKNNELILEARNVTKQFKVSKNNILTACDNINLSMYKGKTLGIVGESGCGKSTFLRMLMNLEKISSGEIFYKGKDISKFSKDEIWESRQHIQMVYQDPGASFNPRMKVVDILTEPLINYDRLKKEDKEKKAIELLEMVDLPADFIHKYPHNMSGGQKQRIGIARALSLEPEVLVCDEATSALDVSIQKNIIELLVKLQKERDLCIVFICHDIALVQSFAHEIAVMYLGNVLEVLPGEKLKDSAYHPYTKALLSSLFSINMDFSKKITSIEGDVPSPINLPSGCVFQGRCKFVKDKCKGHKPILEDIEKKHEVACYFTKEINNL
>NC_021281.1|WP_005910615.1|1955880_1956666_+|ABC-transporter-ATP-binding-protein
MLEIKDLTIQYGEKDAVVENFSLTMEKDEIISIVGESGSGKSTVLRSIIGGLLGQGKVVSGDIIFNGKSLLNLSNNEWRELRGTVISMISQDCGATLNPIRKIGSQYIEYINAHTNLNKAEAEKKALFMLEKVRLPEVKNIMNSYPYELSGGMKQRVGIAMALTFEPELILADEPTSALDVTTQAQIVKQMMEIREEFHTGIIIVTHNMGVAAYMADKIIVMKNGVVVDNGTREEIINNPKSDYTKKLLKAIPEMDGERFV
>NC_021281.1|WP_008798658.1|1954288_1955869_+|ABC-transporter-substrate-binding-protein
MKIFTKKSFAFLMAILMMFTLVACGGDKKEETSATGAANGNGELVVGVTSFADTLEPTEQYFSWVITRYGVGENLVRFDENGELEPSLAEEWKVSDDKLTWEFKIRDGVKFSNGNPLTAEAVKSSFERTFKKSKRAEGFFKPTSIVADGQTLKITTEKPVAILPQCLADPLFLIIDTSDNVEEYTTNAPICTGPYVFKEFVPTEYAIVERNENYWGGKPGLAKVTFKCINDQSTRALSLKSGEIGVAYNLKIENKADFEGQDDINIQELKSLRSTYAFMNQHGVLKDIALRQALLRALNKKAYCEDLLGGAATPGKAPIPPTLDFGFDKLVDENAYNPESAKEILAKAGYKDVDGDGFVEKPDGSKLDLNFVIYTSREELKVYAQAAQANLKDVGIKVTLKTVSYETLLDMRDSGNFDLLIWNVLAANTGDPEKYLYENWDSESASNQAGYKNAKVDELLDKLNAEFNPEKRKELAIEIQQLIMNDAATVFFGYETTFLFSNKKVQNLKMFPMDYYWLTKDVTVAE
>NC_021281.1|WP_005910618.1|1953179_1954010_+|ABC-transporter-permease
MKVTKFIKLHKQLVFFLIMALLIVLVAIFAKQIAPRDPLIAIMERPLRAPDKINLLGTDTLGRDILSRIIYGARYSLFMTLILVAVVFILGTTLGLLAGYFGGIVDTIIMRLADMMVSFPGIILAIAIAGLLGPSMTNAIIAISAVTWPKYARLSRSMVLKIKKELYVEAARLTGSRDKDILFKYILPNMVTLMLVTAISDIGALMLEISALSFLGFGAQPPIPEWGSMLNEGRTYLAKAPWLMLYPGMAIVIVVVVFNMLGDNIKDLIDIKEEDF
>NC_021281.1|WP_005910619.1|1952240_1953179_+|ABC-transporter-permease
MVKNHFVNRILQILIVLFGISFFTFSLTYLSPGDPAEIMLTECGNIPTPELVEQTRAELGLDKPFAEQYFKWASNVAHGEFGKSYSLRVPVVSKIKTAFMPTLKLSLLSLTFMIIISLPLGILAALKVNKWQDYFVRAISFTGLSIPSFWLGLIFLSIFGVMLHWVTVSGGKADFKSLILPAFTLGFAMSAKYIRQVRHTVLEELNKDYVVGARMRGIKESTILIKHVLPNALIPLITLLGLSLGSLLGGTAVIEIIYNFPGMGNLAIKAISYRDYPLVQAYVLLIALIYLVINLIVDFSYKLLDKRVEGAN
>NC_021281.1|WP_008798663.1|1971228_1971936_-|LrgB-family-protein
MSEIIQKILFSPFFGIVLSLIAYEIGKYFFSKTKSIFCNPLLIGIILTIVFLMVLNIPFEAYDKGGSIIKIFISPVESVIIGVALYEQFQILKRNWFPIIVSTVLGSTFSIIILYILGKVFGLPDDIFHATLPKSVTTAIALDIASKNGWQEALIPMMTVSTGIIGAVIAPVVTKFMKSRVAKGLAMGTASHAVGTAKAIEMGEVEGAMSGLALSLSAISTSFMIPLLLSTILKL
>NC_021281.1|WP_005910606.1|1971928_1972312_-|CidA/LrgA-family-protein
MGQWIIILALALVGQFVSDLISFPIPKTIIASIILFLLLEFKVVKADYFKEALASCKKHLAFLFLPVGVGIMTQLKSEPAMVYVKVLIIMIISTILIMLVTGVLADIIIGAQEKILGDKDKKEGKNE
>NC_021281.1|WP_008798665.1|1972342_1973314_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MGKNIMVYIETADNSPINVSLEALTLAKKISKENNEQVIAVLIGENLDEAAKKCFDYGADEVLYVEENKKELEAVGNALTDIKEKYNPSVIFLGSTINGKDLANIVASKMKTPAFVDAVNVKYENGKYLMTLPMYSGNILKEVTFEGDKTLVVAVRSGACKKEVCENAKSGEVKKEKAADKNLFTKIAEIVQEISETVNLEEAEVIVSGGRGMGSKENFELVKQLAEVCGGVVGATRPATEDEWIPRSHQVGQSGKIVAPKLYIACGISGATQHVSGIMGSNYIVAINKDEDAPIFDVADVGIVGNVMDIIPIMIEEIKKIKS
>NC_021281.1|WP_008693323.1|1973325_1974105_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MEILVCIKQVADDSVEIFMNEKTGKPALEGVEKVVNAFDTYALEMAVRLKEAKGDTTVTTLSLGGEDAKNSLKNCLAVGADEAFYIKDENYQEKDAVIIAQALSNGIKKIEEQRGKKFDIIFCGKETTDFATGQVGIMLADELNYGVVTNLVDIDTEGEKVIAKKETETGYEKVEVASPCIVTVNKPNYEPRYPTIKSKMAARKKAIAEISIEVTNESAVKEVKLFSPPKRQAGVKIKTGTAEELVAQAIQKMLEAKVF
>NC_021281.1|WP_005910602.1|1975285_1976713_-|FAD-binding-oxidoreductase
MGNHIYNKVSEDLVEKFKKIVPGKVYTKDEINKDFFHDEMPIYGEGEPEVVIDVTTTEAISEIMKLCYENNIPVTPRGAGTGLTGAAVAVTGGVMLNMTKMNKILGYDYENFVVKVEPGVLLNDLAEDALKQGLLYPPDPGEKFATLGGNVSTNAGGMRAVKYGTTRDYVRAMTVVLPTGEIIKLGATVSKTSTGYSLLNLMIGSEGTLGVITELTLKLIPAPKETISLIIPYENLDECIATVPKFFMNHLQPQALEFMEREIVLASERYIGKSVFPQKLEGVDIGAYLLVTFDGNNMEELEEITERASEVVLEAGALDVLVADTPAKKKDAWAARSSFLEAIEAETKLLDECDVVVPVNQIAPYLHYVNETGKKYDFAVKSFGHAGDGNLHIYACSNDMEMGEFKRQVEEFLMDIYKKASELGGLISGEHGIGYGKMQFLADFSGEVNMRLMRGIKEVFDPKMILNPNKVCYKA
>NC_021281.1|WP_008798666.1|1976941_1978108_-|ArsA-family-ATPase
MRILIYTGKGGVGKTSIAAATAFFLANSGKKVILMSTDQAHSLGDVLDKKLNGKISQVFQNLDVVEIDPIEESQKVWRNLQDYLKQIISAKANDGIEIDETLLFPGLEEIFSLLKILDIYEANEYDVMVVDCAPTGQSLSMLTYSEKLNMLADTILPMVQSINSIFGSFISKKTSVPKPRDIVFEEFKSLVKRLTKLYEIFHKRDSTSIRIVTTPEQIVLEEARRNYTWLQLYNFNVDAVYMNKLYPKEAMEGYFEGWENIQKDNIHLAEESFSEQKLFKLELQSGEIHGREALEKIARLLYKTINPAEIFCQAESFKIEEVNGTRILTIHLPFAKEENISVIKEKYDIIISLLNETRRFHLPDKLKTRKISEYSYKNGELKINMDYE
>NC_021281.1|WP_016340051.1|1978104_1979295_-|ArsA-family-ATPase
MARIIIFTGKGGVGKSSVAAAHALSSAKMDKKTLLVSADTAHNLGDIFKIQIGSKITKISENLDALELDSDVVKREIFPEVKNTMLDLMGKSGIGITNLNENFSLPGFENLFSLLKIKEIYETNQYEHILVDCAPTGETLALLKLPELLAWYMEKFFPIGKKIVRVLSPISKLAYKVVLPSAKTMNTIEHIHKKLLELQELLKNNEICSVRLVCIPEKMIVEETKRNFMYLNLYRYQVDTVFINRIITDEIENTFMQKWKKIQSKYIKELEEVFFDIPVVKIPWYPKEIVGETGLELLCNTIEKLPDLFSVKKVTQNEEYFPCKDGYLLKIQLPFVKEEELKIYHHEMDINIKINNVNRCIPLPNILRKSHIVDTKLENGNLYIHFQVEKKKEEKS
>NC_021281.1|WP_005910598.1|1979507_1980059_+|lactate-utilization-protein-C
MKSITDDLYESFKKNLESVNGNCMRTPKAELGKVITELFKEHNVDSVSLFESPMLKEAGVISSLQQNGITVHTDHIRLHAETDKGGLSEAQHGIAELGTIVQEQDDVDGRIVATMSEYYIGVVKGSTIVPTYDDMFDILSGMKKIPNFVGFITGPSRTADIECVGTVGVHGPIEVSIVIVDDE
>NC_021281.1|WP_005910596.1|1980101_1982261_+|LUD-domain-containing-protein
MASEDLKKEIHFALENATLGRTLGNFCKTYPARREKSYAGVDFEKTREKIAEVKSYAAEHIDEMIAEFTTNCEARGGHVYHAKSTEDAMDWIRKLVKEKGVKTIVKSKSMASEEIKMNHVLGDDGVLVQETDLGEFIIALEGNTPVHMVMPALHLNKEQVADLFTDYTKVKNNPIISEEVKTARKVMRDKFTHADMGVSGANVAVAETGTVFTMTNEGNGRMVGTLPPIHLYIFGIEKFVKSLSDARYIFKALPRNGTAQRITSYISMYTGACEVTTDKEKDEKCKKDFYCVILDDPGRREILAEPDFREIFNCIRCGACLDVCPAFALVGGHVYGSNVYTGGIGTMLTHFLVSEERAAEIQNICLQCGRCNDVCGGGLHISDMIMKLREKNMKEHPDALKKFALDAVSDRKLFHSMLRIASVAQGMFTKGEPMIRHLPMFLSGMTKGRSFPAIAQVPLRDFFHTIKQDVKNPKGTIAIFAGCLLDFVYTDLARAVVADMNSIGYKVEMPLGQACCGCPATNMGDTENAKKEAEINIKGMEAEKYDYIVSACPSCTHQLHLYPTFFEEGTEMHKKAKELADKTYDFCKLFYELGGMSEEGDGKPIKVTYHDSCHLKRSLKVSKEQRELLKHTKGVEFIEMNDCDNCCGFGGSYSLLYPEISAPILEKKIQNIKESGADVVALDCPGCLMQIKGGLDARGINDIKVKHTAEIIAEKRGLI
>NC_021281.1|WP_008798668.1|1982261_1983242_+|polyprenyl-synthetase-family-protein
MIEILLKKWIEQIKYYIHLIADYSIKESQVGAVLDDVLNLSGKMFRSKLLLLCAFLGSNWKNNKEKICKLAAMVELTHLASLIHDDIVDDSPYRRGKVSIQGKYGKDAAVFAGDFLMARIFYYGAVENLNEAVSILSKTVEYMCIGEIEQDLCRYQEDISENKYFENIERKTAALFQAASYIGAKESGCSEEIIQKLELFVKNLGLMFQLKDDILDFTSNSKELGKETHKDFQNGIYTFPVIMALKNPKAREVLLPIMRKNKEEKLSLAEILQLQNYIIQFGGIEASYEKIKYLSTINRQLIKELGQNSEITVYLEKMLNDLEVEK

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Crispr_ID: NC_021281_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021281_6

2087591-2087784

Orphan

Consensus_repeat	Method
AAGACTGGCGCTCTACCAACTGAGCTA	PILER-CR

2 spacers

The CRISPR arrays of NC_021281_6

>merge|NC_021281|6|2087591-2087784|PILER-CR
AAGTCGTGTGCTCTACCAACTGAGCTAATGACGCAAATGGGGTGACCGACGAGGATCGAACTCGCGACAACCAGTGCCACAAACTGGCGCTCTACCAACTGAACTACGGTCACCATAACTATACTTGGAGCGGGAAACGAGGATCGAACTCGCGACATTCAGCTTGGAAGGCTGACGCTCTACCAACTGAGCTA

>NC_021281|6|3|2087591-2087784|PILER-CR
AAGTCGTGTGCTCTACCAACTGAGCTA	ATGACGCAAATGGGGTGACCGACGAGGATCGAACTCGCGACAACCAGTGCCA
CAAACTGGCGCTCTACCAACTGAACTA	CGGTCACCATAACTATACTTGGAGCGGGAAACGAGGATCGAACTCGCGACATTCAGCTTGG
AAGGCTGACGCTCTACCAACTGAGCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_021281.1\|WP_005910479.1\|2096686_2097469_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NC_021281.1\|WP_016340093.1\|2092653_2093523_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223687
NC_021281.1\|WP_005910484.1\|2091625_2092651_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NC_021281.1\|WP_005910482.1\|2093830_2095804_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_021281.1\|WP_005910496.1\|2077609_2078299_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|225512
NC_021281.1\|WP_005910485.1\|2090855_2091629_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NC_021281.1\|WP_005910486.1\|2089642_2090593_-\|TIM-barrel-protein	unknown	unknown	gnl\|CDD\|366542
NC_021281.1\|WP_005910491.1\|2083647_2084373_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|224982
NC_021281.1\|WP_005910494.1\|2078762_2080400_+\|tryptophanase	unknown	unknown	gnl\|CDD\|225576
NC_021281.1\|WP_005910489.1\|2086238_2087087_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NC_021281.1\|WP_005910498.1\|2076082_2076370_-\|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	unknown	unknown	gnl\|CDD\|274102
NC_021281.1\|WP_005910492.1\|2082175_2083621_-\|sodium:alanine-symporter-family-protein	unknown	unknown	gnl\|CDD\|224040
NC_021281.1\|WP_005910493.1\|2080523_2081858_+\|sodium-dependent-transporter	unknown	unknown	gnl\|CDD\|223805
NC_021281.1\|WP_005910480.1\|2096233_2096605_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133384
NC_021281.1\|WP_005910490.1\|2084465_2086010_-\|AbgT-family-transporter	unknown	unknown	gnl\|CDD\|225525
NC_021281.1\|WP_005910487.1\|2089355_2089568_-\|hypothetical-protein	unknown	unknown	unknown
NC_021281.1\|WP_005910488.1\|2087934_2088972_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_021281.1\|WP_016340092.1\|2076643_2077591_-\|DUF285-domain-containing-protein	unknown	unknown	gnl\|CDD\|308794
NC_021281.1\|WP_005910478.1\|2097550_2097928_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|129116
NC_021281.1\|WP_005910499.1\|2075795_2076086_-\|type-II-toxin-antitoxin-system-YafQ-family-toxin	unknown	unknown	gnl\|CDD\|379750

Protein	Function_ID	Function_description	E-value
NC_021281.1\|WP_005910479.1\|2096686_2097469_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	1.009e-72
NC_021281.1\|WP_016340093.1\|2092653_2093523_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223687	COG0614, FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism].	7.87103e-37
NC_021281.1\|WP_005910484.1\|2091625_2092651_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	5.18738e-92
NC_021281.1\|WP_005910482.1\|2093830_2095804_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	8.81709e-57
NC_021281.1\|WP_005910496.1\|2077609_2078299_-\|PAS-domain-containing-protein	gnl\|CDD\|225512	COG2964, COG2964, Uncharacterized protein conserved in bacteria [Function unknown].	8.91124e-74
NC_021281.1\|WP_005910486.1\|2089642_2090593_-\|TIM-barrel-protein	gnl\|CDD\|366542	pfam01261, AP_endonuc_2, Xylose isomerase-like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.	9.7746e-13
NC_021281.1\|WP_005910491.1\|2083647_2084373_-\|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl\|CDD\|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	1.35795e-86
NC_021281.1\|WP_005910494.1\|2078762_2080400_+\|tryptophanase	gnl\|CDD\|225576	COG3033, TnaA, Tryptophanase [Amino acid transport and metabolism].	0
NC_021281.1\|WP_005910489.1\|2086238_2087087_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	7.06687e-51
NC_021281.1\|WP_005910498.1\|2076082_2076370_-\|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin	gnl\|CDD\|274102	TIGR02384, Putative_antitoxin_RelB, addiction module antitoxin, RelB/DinJ family. Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other].	5.3421e-15
NC_021281.1\|WP_005910492.1\|2082175_2083621_-\|sodium:alanine-symporter-family-protein	gnl\|CDD\|224040	COG1115, AlsT, Na+/alanine symporter [Amino acid transport and metabolism].	6.83141e-152
NC_021281.1\|WP_005910493.1\|2080523_2081858_+\|sodium-dependent-transporter	gnl\|CDD\|223805	COG0733, COG0733, Na+-dependent transporters of the SNF family [General function prediction only].	1.73432e-140
NC_021281.1\|WP_005910480.1\|2096233_2096605_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133384	cd01109, HTH_YyaN, Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB. Putative helix-turn-helix (HTH) MerR-like transcription regulators of Bacillus subtilis, YyaN and YraB, and related proteins; N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	2.78435e-46
NC_021281.1\|WP_005910490.1\|2084465_2086010_-\|AbgT-family-transporter	gnl\|CDD\|225525	COG2978, AbgT, Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism].	1.35e-147
NC_021281.1\|WP_005910485.1\|2090855_2091629_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	4.58944e-102
NC_021281.1\|WP_005910488.1\|2087934_2088972_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	6.7195e-11
NC_021281.1\|WP_016340092.1\|2076643_2077591_-\|DUF285-domain-containing-protein	gnl\|CDD\|308794	pfam03382, DUF285, Mycoplasma protein of unknown function, DUF285. This region appears distantly related to leucine rich repeats.	1.77872e-54
NC_021281.1\|WP_005910478.1\|2097550_2097928_-\|RidA-family-protein	gnl\|CDD\|129116	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase. This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other].	6.34361e-62
NC_021281.1\|WP_005910499.1\|2075795_2076086_-\|type-II-toxin-antitoxin-system-YafQ-family-toxin	gnl\|CDD\|379750	pfam15738, YafQ_toxin, Bacterial toxin of type II toxin-antitoxin system, YafQ. YafQ is a family of bacterial toxin ribonucleases of type II toxin-antitoxin systems. The E.coli gene is expressed from the dinB operon. The cognate antitoxin for the E. coli protein is DinJ, in family RelB_antitoxin, pfam02604.	2.56415e-37

>NC_021281.1|WP_005910489.1|2086238_2087087_-|MurR/RpiR-family-transcriptional-regulator
MNEIHKLYKKNYAKLTKTEKRIAEFISKNPKKLITLSALELGKELGVSDASVLRFSKNIGFNKFSDFKNYVALELSEGNLNERIVKNWNNFTSENDLANKIINADLRNIQDFLLNIDFELIERLIDLIEKSEKIYILGIGASRAIAQFMFWHIKRLGYSSECIIEGGFGLYETISKIKKEELLILFAFPKFLNDEINTLKVIKEKRAKSVVITSSLFSEISFLGDIVFRVPIQNNAFLNSYMVPMEFCNIVLTSLFEKNKDKIYEEWKKNNNIKKFLFVQEN
>NC_021281.1|WP_005910490.1|2084465_2086010_-|AbgT-family-transporter
MNERKGIMGKIIAVSNRLPHPVTIFIIFSIIVGILSVIFSKMGVSVEIEAINRSTKQVELQTYSVKSLFDADGIRWIFEEAVPNFIGFAPLGVVLFFSLFFNFLNEVGLFPSFLKKSMQKIKGKYMSLFIAFLGVNSSFAGDIGYVLVIPIAGILYKQLKRNPIAGILLGFSSTSAGFAACLVSIDALLGGLSTSAMSIVNPNYIVTPLANSIFMFFYTFFITFIIAYVNDKFIEPKVNQYFPEELVDNSDIEDNFTELTNDENKGLKYAGIGFLVSIGIILLLSVPSGAPLRNPETGLLLLGWSPLLSAIIPVICLIFFIPGIFYGIATKKIKNDKDLMTLLFKSLDGFGAFIVLCFFSSIFISWFSYSQLGIIIAAKGGQFLSEIGLTRIPLMIVFILFCSFINLFIGSMSSKYVLIAPIFLPMLYKMGVSPELSQLAYRLGDSATNIISPLMSFFPLVLIYCNKYNKKFGFGDLLAYMMPHAIVILITSIIFFGIWLLFNLPIGFNTVNFF
>NC_021281.1|WP_005910491.1|2083647_2084373_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MKKPIIGITSAYEREEELLNYHRTTVSIDYTKSIVATGGIPIVLPVTDDRTIIKAQLSLIDGLILSGGADINPLLYGQDFKAGIGTVSPERDNYEMIVLEEFLKTGKAILGICRGHQLLNVYFGGTLFQDAQYYKGELVNHRQKIYPDMVTHKVNIIEQENILFEAYGREIITNSFHHQFIDKLGDGLTAIAKSNDGVVEAIQMKGHKFLYGIQWHPEMMIARKNEQMKEIFKKFIEASSY
>NC_021281.1|WP_005910492.1|2082175_2083621_-|sodium:alanine-symporter-family-protein
MLKYFEMFVNFLWGLPIIVIILGAGIYFTFKTGFFQVFYLKHIFSETILKTIKTGNKGEGNAKGLITPFDAVATAIGGTVGVGNIGGVATAIAIGGPGALFWLWIAAFLGMMLKMVEVTLGVYYREKDENGEVYGGPTYYMEKGLGKEKGIKWWIIPAVIFGGGIFSTFFITVQNYTVSEAVSSAYGIKIIYASIIYILVNYILIIGGIKKLGKIAGKIVPFMCIFYIVAALYIIAINIGNLPETIVLVFKGAFNGTAAVGGFAGAAFNQVMRIGMARSVFSNEAGWGSSPMIHSSAQTDHPVKQGLWGAFEVFVDTIIVCTLTALVIIITNVWQSGATGATLTLSAFETGMGLASKIFIATGIFLFGVTTSSGWYAYYEIILRHLMKSRPKLKEAILKFYKIFYPIPGFIMVVMATTIGMPGGTVWVFADFTTAIPTFVNVGVILALSGTFLKLFKDYKKRYILKEDMSKENTKLFFEEN
>NC_021281.1|WP_005910493.1|2080523_2081858_+|sodium-dependent-transporter
MSAIEKRDGFTTKWGFILACIGSAVGMGNIWRFPVLVSELGGMTFLIPYFIFVILIGSTGVIEEFALGRAAGAGPVGAFGMCTEMKGNRSIGEKIGIIPILGSLSLAIGYSCVMGWVFKYAWMSINGSMYAMQSNMEVIGSTFGQTATKWGANFWIIIALIASFAIMSMGVSGGIEKANKIMMPILFILFVLLGIYIVFQPGSSNGYKYIFTVNFEGLLNPKIWIFAFGQAFFSLSVAGHGSVIYGSYLSKSEDIPNSARNVALFDTLAALLAAFVIIPAMAVGGAELSSGGPGLMFIYLVNIMNNMAGGRIIEVIFYLCVLFAGVSSIINLYEAPVAFLQEKFKANRVTATAIIHIIGCIVAICIQGIVSQWMDVVSIYICPLGALLAAVMFFWVAGKEFAEEAVNMGASKKIGNWFYPAGKYVYCLLALVALIAGALLGGIG
>NC_021281.1|WP_005910494.1|2078762_2080400_+|tryptophanase
MKEYLLDVPVPRSFSYVKRNIPEVTVEQRERALKATHYNEFAFPAGMLTVDMLSDSGTTAMTDQQWSAMFLGDESYGRNKGYYVLLDAMRDCFERGDNQKKIINLVRTDCQDIEKMMNEMYLCEYEGGLFNGGAAQLERPNAFLMPQGRAAESILFEIVRKILAAREPGKVFTIPSNGHFDTTEGNIKQMGSVPRNLYNKELLYEVPEGGRYEKNPFKGDMDINKLQKLIDAVGAENIPMIYTTVTNNTVCGQAVSMKSIRETAKIAHKYEIPFMLDAARWAENCYFIKMNEDGYRDKSIPEIAKEMFSYCDGFTASLKKDGHANMGGILAFRDKGYFWKKFSDFNKDGTVKTDVGILLKVKQISSYGNDSYGSMSGRDIMALAAGLYECCNFNYLQERVEQCNYLAEGFYKAGVKGVVLPAGGHGVYINMDEFFDGKRGHESFAGEGFSLELIRRYGIRVSELGDYSMEYDLKTPEQQAEVANVVRFAINRSVYSQEHLDYVIAAVKALYEDRESIPNMRIVSGHNLPMRHFHAFLEPYPNEEK
>NC_021281.1|WP_005910496.1|2077609_2078299_-|PAS-domain-containing-protein
MRNELLNQYKILVNFLGKTLGPSFEIVLHEIKGEEVKMIAIANGEISNRTLENSISSETLNILKNKSYHNEESMVNHTVLLKNGKKVRSSSMFIKENKKIIGMLCINFDDSKFHDINCQILRIIHPDMFVKNYLSDVSYNILVDENKNQDNEENSTDNMENFMEKVFQEVNLKFNYPLERLTKQEREKIVKALYEKGIFNLKEAINFVAKKLSCSPTTVYRYVGKIEKK
>NC_021281.1|WP_016340092.1|2076643_2077591_-|DUF285-domain-containing-protein
MRKILLLFMMLLFAISASSKDFKYHPKTKDELKELIENEAIYLGDIDTSAITDMSYLFIRERKKIDSCGTAYDYKTIKRKNFSGIGKWDTSNVTDMRGLFYNLKNFNEDISAWNTSKVEDMLSMFEDADNFNQALNNWDVSKVKTMKNMFRGAISFNQPLNKWNVSEVIDMSEMFEAAYKFNQALNSWDVSNVKDMSYMFNNAKEFNQPLDNWNVSNVEDMSHMFSNAKKFNQPINSWNVSKVEYMDYMFDEAKSFNQSLNLWDVSNVKNMHCMFCEAKSFNQDLSMWKVRGTTFTVNMFLGSPLENREPKWEGH
>NC_021281.1|WP_005910498.1|2076082_2076370_-|type-II-toxin-antitoxin-system-RelB/DinJ-family-antitoxin
MMSNINVMVDEEITKEATEIFTKLGFDMNTAINIFLRSAIRKKGIPFDLLVDEVDDFANFNDETIEAIEEAERICKDPNRKRFSSSKELREAFGI
>NC_021281.1|WP_005910499.1|2075795_2076086_-|type-II-toxin-antitoxin-system-YafQ-family-toxin
MSKKEIKYQLDPTNKYLNDLKLAKKQGKNLDKLDEIVDILAAGKQLEPKYKDHKLNGKYQGYRECHIEADWLLIYKKFDSILVLILLRTGSHSELF
>NC_021281.1|WP_005910488.1|2087934_2088972_-|tetratricopeptide-repeat-protein
MDEKFWEQINTFGENGEFDKIIREIKKLPEEKLNIELINVLGRAYMNLGDYENALDTYLSYIGKNKEDVTNADIWIYSECGWLCNEVGDYERGLKYLLEAEKLGRDDEWLNTEVGQCLGRLGRAEEGIARLKKSLKLIETEAPENINEKIFINSEIGYLYGFLEIPEEALKYFYITKDLGRNDEWLYMHLWFNLERFKGKEEALKYFENEVKDNDKNVVFWASLGQVYMNFLENYEEAEKAFKKAFELSGDGLYLYNRGIALRMLGRYEEAIEILLQSRKISVQEGDVTDGEDSELVRCYIALKDKENARKYLESAKEGVKNIPEEHVNEFKNTLKELEDSIAKI
>NC_021281.1|WP_005910487.1|2089355_2089568_-|hypothetical-protein
MNRDAKFINFSEEHELDYILKKYGKEPSKENRDFLKEFGKKAKELLGKTMLGHEEFYKYLEDNSLIKTLK
>NC_021281.1|WP_005910486.1|2089642_2090593_-|TIM-barrel-protein
MYKLLNIADFCSNEEVEKDMQYFSKKYGFDGFELIKFFNENNSPLKKYIKGYHMRFFPSWMELYLEDFNSLYAELKDKKYFKFLCGGHSKKELIEYYKRELKIAKELEVEYVVFHACNVKVTEAMTYDFKYSDREVLNAVISIINEIFEDGEYDFKLLFENLWWSGLRLTNKEEIEYLLNGVKYKNVGFILDTGHMINNNRDIKNSKEGIEYIKKNIDNIGEYKNLIYGMHLNYSLSGEYIKKSIKENKEKNLSIEEIMENVYQHVGAIDYHDPFEDKEIIKVINSLPIKYLVFELIGNTREELEDKIQRQWKIFN
>NC_021281.1|WP_005910485.1|2090855_2091629_-|ABC-transporter-ATP-binding-protein
MKNILEVKNISYSVGENKILKDINFKCQSGEIIGIIGPNGSGKTTLLKTINGINPISSGDILLNGKSIKEYDEKELARDISFMNQNTNIEFDFPCIDIVVLGRYPYLERFQEYSKKDMELAEKYMKLTNTYKFRDKSILQLSGGERQRVLFAKILTQESQVILLDEPTASLDMRYEEDLLKEVSKEKDKGKIIILVIHNLRTAIKYCSRLVLLSNGNIIKDGAVKEVITEENLNNVFGIKTKVYYNEISKSLDFCII
>NC_021281.1|WP_005910484.1|2091625_2092651_-|iron-ABC-transporter-permease
MKYRINFNLFLFFLLIGIIIFSLFYGAVRVPVSDVIKIILNKTGLFNFEISKQSYIPIVFFVRFPRIMVAVIVGGALALCGCTMQSLLKNPIVDSGIIGISSGASLGAVIAVSLGLTATNIFVMPIFSGAFALIISAIIYKISTLRGRTDNLLLILSGIAIGSFVGAITSAILTSLEETEMKEYIFWAMGSLNGRRWEHFFFGLIPIAILSPILFYYGKELNILLLGEEEAKSLGINIKKIRGKILIIIALLTAISVCISGNITFVGLIVPHILRKLIGSDNRKLLKSSFLAGACFLTFSDLVSRIVLAPKEISVGIVTALIGAPYFIYLIVKIRREGKTL
>NC_021281.1|WP_016340093.1|2092653_2093523_-|ABC-transporter-substrate-binding-protein
MKKLFLFIILLFSFTIVNAKGVQTKKYNHIVSLTLSGDEMLLGLVSENRIAGLSGKINEDKEISNIVDKSKKFLKVEGNEEVLISLEPDLIIVADWLSKRIDDIGAMTGAKVYIYKTPSSYEEQKKLIRDLANLVEERENGEKIIKNMDNRLKSLQNKIAKNCKGAKPRILLYTSFGTTSGKNTTFDDMVKLINGVNVVAEAGIDRFKDISKEKVIELNPDIIIVPIAKKYDNVDKISKLFFEDPSFKNVKAIKNKKVYFIQYKDITPTSQYMINSIEELAKVVYQFKE
>NC_021281.1|WP_005910482.1|2093830_2095804_-|TonB-dependent-receptor
MKKKFLLLALIVLGGISAFAEESPVLELKQTVVTSDSFGTPVRETAKNMTVISAKEIKEKGAKTIADALRGVPGIVVRQMDGASPMIDLRGSGATAQFNTVILLDGIPVSGLAGFNLNTVPVDEIEKIEVLQGAGAVMYGDGAIGGVVNIITKAPTKKTVYGGAGLEVGSWRTIRENVYLGGKIGDKFLLNGSYSGNTSKDYRDRSPQYENKKDKRDSLWLRGKYLLDNGSIAINYNHSEDKDYYTGSLSKEQFDDNPRQVGSWNGYTYGIDDIINAKYNQKINDKIDIFLTSGYYHNKDKFQKNSTSEYFLRPEVKVTYAKDSYVTLGLDYRDGKRKFKDDVFINGVSQKAPDDKRESFAGYIMNKSTFGNWQFTQGYRREKVKYEYSSKVYDPMTWQLKEIKPKSADYANNDSFEFGVNYLYSDTGNVFFNYTRALRTPTIQDAGAWYGPVKTQKNDIFEIGLRDAYKNTSISTSVFYINSKNEIYYDKTNPFSSNNQNFDGKVRRIGAQLSLAHYFDKLTLRERVSYIVPKVTSGTYDGKEFAGVSRWTANVGATYNITKGLTANIDGYYQSNAYAEDDFDNYFSKGNSYVTVDANLSYAFENGIELYTGVSNLFDKNYANAVTSTRSTFGAGPRKVYYPANGRSVYAGIKYTF
>NC_021281.1|WP_005910480.1|2096233_2096605_-|MerR-family-transcriptional-regulator
MEYSIGEFSKLTGLSIHTLRYYEYEQLIVPMRNKNNIRRYSDKDIAWIDFIKRLKDTGMPIKKIKEYAKLRSKGDITLSKRMEMLIQHYGFLEKQISILQEHKEKLDQKIKYYQVQINLLDSE
>NC_021281.1|WP_005910479.1|2096686_2097469_+|SDR-family-NAD(P)-dependent-oxidoreductase
MIKNKYVVITGASSGIGYEAAKAFADRGKNLIIVARRKNNLEKLKEEILEKYPKLDIVIKVTDLSITENLYYLYNELQKYELETWVNSAGFGNYASAAEQDLKKINSMLHLNIEAVTILSSLFVRDYKDKKGTKLINISSCGGYVIVPTAITYCATKFYVSSFTEGLAHELKEENAKMEVKVLAPAATKTEFGKIANNVEEYNYDKLFGTYHTSKQMAYFLMKLYDSDKVVGIVDRETFEFQLLNPIFQYAGNSKHNQKR
>NC_021281.1|WP_005910478.1|2097550_2097928_-|RidA-family-protein
MKKIINTTNAPAALGPYSQAIEANGVLYVSGQIPFVPATMTLVSEDVEAQTKQSLENIGAILKEAGYDFKDVVSATVYIKDMNDFTKVNGVYDKYLGEVKPARACVEVARLPKDVKVEIGVIAVK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021281_1	1.12\|173724\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173724-173758	35	KR131710	Fusobacterium phage Funu1, complete genome	11913-11947	0	1.0
NC_021281_1	1.15\|173922\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173922-173956	35	KR131711	Fusobacterium phage Funu2 supercont1.1, partial genome	13774-13808	0	1.0
NC_021281_1	1.34\|175171\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175171-175206	36	KR131711	Fusobacterium phage Funu2 supercont1.1, partial genome	10600-10635	0	1.0
NC_021281_1	1.37\|175368\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175368-175402	35	KR131711	Fusobacterium phage Funu2 supercont1.1, partial genome	35746-35780	0	1.0
NC_021281_1	1.39\|175499\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175499-175534	36	KR131710	Fusobacterium phage Funu1, complete genome	2200-2235	0	1.0
NC_021281_1	1.3\|173131\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173131-173166	36	KR131711	Fusobacterium phage Funu2 supercont1.1, partial genome	16010-16045	1	0.972
NC_021281_4	4.2\|1858370\|26\|NC_021281\|PILER-CR	1858370-1858395	26	MH937494	Streptococcus phage CHPC1042, complete genome	20913-20938	3	0.885
NC_021281_4	4.2\|1858370\|26\|NC_021281\|PILER-CR	1858370-1858395	26	MG708275	Streptococcus phage vB_SthS_VA460, complete genome	29011-29036	4	0.846
NC_021281_4	4.2\|1858370\|26\|NC_021281\|PILER-CR	1858370-1858395	26	NZ_CP010194	Escherichia coli strain M8 plasmid C, complete genome	7075-7100	4	0.846
NC_021281_4	4.2\|1858370\|26\|NC_021281\|PILER-CR	1858370-1858395	26	MF161328	Streptococcus phage D4276, complete genome	19817-19842	4	0.846
NC_021281_4	4.2\|1858370\|26\|NC_021281\|PILER-CR	1858370-1858395	26	MH937474	Streptococcus phage CHPC930, complete genome	20321-20346	4	0.846
NC_021281_5	5.1\|1970988\|26\|NC_021281\|CRISPRCasFinder	1970988-1971013	26	NZ_AP017562	Pseudanabaena sp. ABRG5-3 plasmid ABRG53b, complete sequence	31478-31503	4	0.846
NC_021281_4	4.2\|1858370\|26\|NC_021281\|PILER-CR	1858370-1858395	26	NZ_CP038617	Arsenophonus nasoniae strain FIN plasmid pArsFIN5, complete sequence	98547-98572	5	0.808
NC_021281_1	1.21\|174316\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	174316-174351	36	NZ_CP018299	Photobacterium damselae strain Phdp Wu-1 plasmid plas1, complete sequence	304163-304198	8	0.778
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NZ_CP019922	Borreliella burgdorferi strain PAbe plasmid p_lp17, complete sequence	8490-8525	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NC_018992	Borrelia burgdorferi 297 plasmid 297_lp17, complete sequence	7158-7193	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NC_011782	Borreliella burgdorferi ZS7 plasmid ZS7_lp17, complete sequence	8904-8939	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NC_017417	Borreliella burgdorferi N40 plasmid N40_lp17, complete sequence	11813-11848	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NC_015915	Borreliella bissettii DN127 plasmid lp17, complete sequence	16625-16660	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NZ_CP031400	Borreliella burgdorferi strain MM1 plasmid plsm_lp17, complete sequence	6664-6699	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NZ_CP019851	Borreliella burgdorferi plasmid lp17, complete sequence	8510-8545	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NZ_CP019761	Borreliella burgdorferi strain B31_NRZ isolate B31 plasmid p_lp17, complete sequence	8511-8546	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NZ_CP015803	Borrelia mayonii strain MN14-1539 plasmid lp17	14545-14580	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NC_004988	Borrelia burgdorferi ATCC 35210 plasmid lp16.9, complete sequence	8306-8341	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NZ_CP017211	Borreliella burgdorferi strain B331 plasmid B331_lp17, complete sequence	6822-6857	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NZ_CP015788	Borrelia mayonii strain MN14-1420 plasmid lp17, complete sequence	14545-14580	9	0.75
NC_021281_1	1.8\|173461\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173461-173496	36	NC_001849	Borreliella burgdorferi B31 plasmid lp17, complete sequence	8276-8311	9	0.75
NC_021281_1	1.11\|173658\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173658-173693	36	NZ_CP009593	Bacillus cereus strain 3a plasmid pBFC_1, complete sequence	5569-5604	9	0.75
NC_021281_1	1.11\|173658\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173658-173693	36	NZ_CP009604	Bacillus cereus strain S2-8 plasmid pBFR_1, complete sequence	4021-4056	9	0.75
NC_021281_1	1.11\|173658\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173658-173693	36	NZ_CP053993	Bacillus cereus strain FDAARGOS_781 plasmid unnamed3, complete sequence	3868-3903	9	0.75
NC_021281_1	1.11\|173658\|36\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	173658-173693	36	NZ_CP053995	Bacillus cereus strain FDAARGOS_780 plasmid unnamed2, complete sequence	382-417	9	0.75
NC_021281_1	1.29\|174840\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	174840-174874	35	NZ_CP029155	Clostridioides difficile strain CD161 plasmid unnamed1, complete sequence	65627-65661	9	0.743
NC_021281_1	1.17\|174052\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	174052-174086	35	MH321491	Staphylococcus phage Twillingate, complete genome	25093-25127	10	0.714
NC_021281_1	1.44\|175829\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175829-175863	35	NZ_CP034685	Bacillus sp. BD59S plasmid pBTBD59S2, complete sequence	195648-195682	10	0.714
NC_021281_1	1.44\|175829\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175829-175863	35	NZ_CP043832	Bacillus sp. BS98 plasmid unnamed2	54880-54914	10	0.714
NC_021281_1	1.44\|175829\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175829-175863	35	NZ_AP014865	Bacillus thuringiensis serovar tolworthi strain Pasteur Institute Standard strain plasmid pKK1, complete sequence	147623-147657	10	0.714
NC_021281_1	1.44\|175829\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175829-175863	35	CP024685	Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence	87421-87455	10	0.714
NC_021281_1	1.44\|175829\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175829-175863	35	NZ_CP042875	Bacillus cereus strain 09 plasmid unnamed1, complete sequence	62769-62803	10	0.714
NC_021281_1	1.44\|175829\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175829-175863	35	NZ_CP040345	Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence	314921-314955	10	0.714
NC_021281_1	1.44\|175829\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175829-175863	35	NZ_CP009368	Bacillus cereus strain FM1 plasmid unnamed, complete sequence	176737-176771	10	0.714
NC_021281_1	1.44\|175829\|35\|NC_021281\|PILER-CR,CRISPRCasFinder,CRT	175829-175863	35	NZ_CP020434	Bacillus sp. FDAARGOS_235 plasmid 1, complete sequence	207222-207256	10	0.714

1. spacer 1.12|173724|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to KR131710 (Fusobacterium phage Funu1, complete genome) position: , mismatch: 0, identity: 1.0

ataactgatactacaaacatatcagaagtatcaga	CRISPR spacer
ataactgatactacaaacatatcagaagtatcaga	Protospacer
***********************************

2. spacer 1.15|173922|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to KR131711 (Fusobacterium phage Funu2 supercont1.1, partial genome) position: , mismatch: 0, identity: 1.0

acttaacggaaagatacttaaaagctatggattaa	CRISPR spacer
acttaacggaaagatacttaaaagctatggattaa	Protospacer
***********************************

3. spacer 1.34|175171|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to KR131711 (Fusobacterium phage Funu2 supercont1.1, partial genome) position: , mismatch: 0, identity: 1.0

aacaatggttttaaaaagaaatggaattgtcttatc	CRISPR spacer
aacaatggttttaaaaagaaatggaattgtcttatc	Protospacer
************************************

4. spacer 1.37|175368|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to KR131711 (Fusobacterium phage Funu2 supercont1.1, partial genome) position: , mismatch: 0, identity: 1.0

aatgaagatgttgattgttatgaacatacagattt	CRISPR spacer
aatgaagatgttgattgttatgaacatacagattt	Protospacer
***********************************

5. spacer 1.39|175499|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to KR131710 (Fusobacterium phage Funu1, complete genome) position: , mismatch: 0, identity: 1.0

acacaacttactaatgaaatagatagttttgttgat	CRISPR spacer
acacaacttactaatgaaatagatagttttgttgat	Protospacer
************************************

6. spacer 1.3|173131|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to KR131711 (Fusobacterium phage Funu2 supercont1.1, partial genome) position: , mismatch: 1, identity: 0.972

cctaaatatagttcaatgcttgtgaatgcagtagac	CRISPR spacer
cctaaatatagttcaatgcttgtaaatgcagtagac	Protospacer
***********************.************

7. spacer 4.2|1858370|26|NC_021281|PILER-CR matches to MH937494 (Streptococcus phage CHPC1042, complete genome) position: , mismatch: 3, identity: 0.885

aattatcattttcaacgttagcttta	CRISPR spacer
aattagcattttcaacgttaggtttt	Protospacer
***** *************** ***

8. spacer 4.2|1858370|26|NC_021281|PILER-CR matches to MG708275 (Streptococcus phage vB_SthS_VA460, complete genome) position: , mismatch: 4, identity: 0.846

aattatcattttcaacgttagcttta	CRISPR spacer
aattagcattttcaacgttaggcttt	Protospacer
***** *************** .**

9. spacer 4.2|1858370|26|NC_021281|PILER-CR matches to NZ_CP010194 (Escherichia coli strain M8 plasmid C, complete genome) position: , mismatch: 4, identity: 0.846

aattatcattttcaacgttagcttta	CRISPR spacer
caatattattttcaacgttagcatta	Protospacer
 * ***.*************** ***

10. spacer 4.2|1858370|26|NC_021281|PILER-CR matches to MF161328 (Streptococcus phage D4276, complete genome) position: , mismatch: 4, identity: 0.846

aattatcattttcaacgttagcttta	CRISPR spacer
aattagcattttcaacgttaggcttt	Protospacer
***** *************** .**

11. spacer 4.2|1858370|26|NC_021281|PILER-CR matches to MH937474 (Streptococcus phage CHPC930, complete genome) position: , mismatch: 4, identity: 0.846

aattatcattttcaacgttagcttta	CRISPR spacer
aattagcattttcaacgttaggcttt	Protospacer
***** *************** .**

12. spacer 5.1|1970988|26|NC_021281|CRISPRCasFinder matches to NZ_AP017562 (Pseudanabaena sp. ABRG5-3 plasmid ABRG53b, complete sequence) position: , mismatch: 4, identity: 0.846

tcatagcctgtatatctatgaatctg	CRISPR spacer
tcatagcctgaatatatatgaatttc	Protospacer
********** **** *******.*

13. spacer 4.2|1858370|26|NC_021281|PILER-CR matches to NZ_CP038617 (Arsenophonus nasoniae strain FIN plasmid pArsFIN5, complete sequence) position: , mismatch: 5, identity: 0.808

aattatcattttcaacgttagcttta	CRISPR spacer
aattatcattttcaactttatctccc	Protospacer
**************** *** **..

14. spacer 1.21|174316|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018299 (Photobacterium damselae strain Phdp Wu-1 plasmid plas1, complete sequence) position: , mismatch: 8, identity: 0.778

ttttattct----attaacatacataaataataattacta	CRISPR spacer
----atagtaataattaacatacataaataatagttatta	Protospacer
    **  *    ********************.***.**

15. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019922 (Borreliella burgdorferi strain PAbe plasmid p_lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

16. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NC_018992 (Borrelia burgdorferi 297 plasmid 297_lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

17. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NC_011782 (Borreliella burgdorferi ZS7 plasmid ZS7_lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

18. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NC_017417 (Borreliella burgdorferi N40 plasmid N40_lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

19. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NC_015915 (Borreliella bissettii DN127 plasmid lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

20. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031400 (Borreliella burgdorferi strain MM1 plasmid plsm_lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

21. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019851 (Borreliella burgdorferi plasmid lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

22. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019761 (Borreliella burgdorferi strain B31_NRZ isolate B31 plasmid p_lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

23. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015803 (Borrelia mayonii strain MN14-1539 plasmid lp17) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

24. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NC_004988 (Borrelia burgdorferi ATCC 35210 plasmid lp16.9, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

25. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017211 (Borreliella burgdorferi strain B331 plasmid B331_lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

26. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015788 (Borrelia mayonii strain MN14-1420 plasmid lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

27. spacer 1.8|173461|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NC_001849 (Borreliella burgdorferi B31 plasmid lp17, complete sequence) position: , mismatch: 9, identity: 0.75

tattttaaaaataatgtcaatacactttttaaaata	CRISPR spacer
aaaataaaaaataatgtcaatacaaattttaataat	Protospacer
 *  * ******************  ****** *

28. spacer 1.11|173658|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009593 (Bacillus cereus strain 3a plasmid pBFC_1, complete sequence) position: , mismatch: 9, identity: 0.75

tcttttacttcaagaaattcttttacaatttctttc	CRISPR spacer
tcaccaacttcaagaaattctttcgcaatttcagcc	Protospacer
** .. *****************..*******  .*

29. spacer 1.11|173658|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009604 (Bacillus cereus strain S2-8 plasmid pBFR_1, complete sequence) position: , mismatch: 9, identity: 0.75

tcttttacttcaagaaattcttttacaatttctttc	CRISPR spacer
tcaccaacttcaagaaattctttcgcaatttcagcc	Protospacer
** .. *****************..*******  .*

30. spacer 1.11|173658|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053993 (Bacillus cereus strain FDAARGOS_781 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.75

tcttttacttcaagaaattcttttacaatttctttc	CRISPR spacer
tcaccaacttcaagaaattctttcgcaatttcagcc	Protospacer
** .. *****************..*******  .*

31. spacer 1.11|173658|36|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053995 (Bacillus cereus strain FDAARGOS_780 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.75

tcttttacttcaagaaattcttttacaatttctttc	CRISPR spacer
tcaccaacttcaagaaattctttcgcaatttcagcc	Protospacer
** .. *****************..*******  .*

32. spacer 1.29|174840|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029155 (Clostridioides difficile strain CD161 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.743

ctataaaca-----attttattggattattggatatttac	CRISPR spacer
-----atcattctccttttattttattattggatatttac	Protospacer
     * **      *******  ****************

33. spacer 1.17|174052|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to MH321491 (Staphylococcus phage Twillingate, complete genome) position: , mismatch: 10, identity: 0.714

tttataaatgtcaatatatttttataacattacaa	CRISPR spacer
gatataaatgtcaatatacttttttaatgtttttt	Protospacer
  ****************.**** ***..** .

34. spacer 1.44|175829|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034685 (Bacillus sp. BD59S plasmid pBTBD59S2, complete sequence) position: , mismatch: 10, identity: 0.714

tcaagttagtttcaagcaacttatcagcttttaat	CRISPR spacer
aatgatacgtttcaagcaagttataagcttttact	Protospacer
   ..*  *********** **** ******** *

35. spacer 1.44|175829|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP043832 (Bacillus sp. BS98 plasmid unnamed2) position: , mismatch: 10, identity: 0.714

tcaagttagtttcaagcaacttatcagcttttaat	CRISPR spacer
aatgatacgtttcaagcaagttataagcttttact	Protospacer
   ..*  *********** **** ******** *

36. spacer 1.44|175829|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP014865 (Bacillus thuringiensis serovar tolworthi strain Pasteur Institute Standard strain plasmid pKK1, complete sequence) position: , mismatch: 10, identity: 0.714

tcaagttagtttcaagcaacttatcagcttttaat	CRISPR spacer
aatgatacgtttcaagcaagttataagcttttact	Protospacer
   ..*  *********** **** ******** *

37. spacer 1.44|175829|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to CP024685 (Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence) position: , mismatch: 10, identity: 0.714

tcaagttagtttcaagcaacttatcagcttttaat	CRISPR spacer
aatgatacgtttcaagcaagttataagcttttact	Protospacer
   ..*  *********** **** ******** *

38. spacer 1.44|175829|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP042875 (Bacillus cereus strain 09 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

tcaagttagtttcaagcaacttatcagcttttaat	CRISPR spacer
aatgatacgtttcaagcaagttataagcttttact	Protospacer
   ..*  *********** **** ******** *

39. spacer 1.44|175829|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040345 (Bacillus albus strain DLOU-Yingkou plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

tcaagttagtttcaagcaacttatcagcttttaat	CRISPR spacer
aatgatacgtttcaagcaagttataagcttttact	Protospacer
   ..*  *********** **** ******** *

40. spacer 1.44|175829|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009368 (Bacillus cereus strain FM1 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.714

tcaagttagtttcaagcaacttatcagcttttaat	CRISPR spacer
aatgatacgtttcaagcaagttataagcttttact	Protospacer
   ..*  *********** **** ******** *

41. spacer 1.44|175829|35|NC_021281|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020434 (Bacillus sp. FDAARGOS_235 plasmid 1, complete sequence) position: , mismatch: 10, identity: 0.714

tcaagttagtttcaagcaacttatcagcttttaat	CRISPR spacer
aatgatacgtttcaagcaagttataagcttttact	Protospacer
   ..*  *********** **** ******** *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

667406 : 698003

uncultured_Caudovirales_phage(22.22%)

integrase,portal,holin,capsid,terminase,plate

attL 662114:662131|attR 688883:688900

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
662114:662131	attL	NA	NA	NA	NA
WP_016339659.1\|667406_668162_+\|integrase	phage integrase N-terminal SAM-like domain-containing protein	NA	NA	NA	NA
WP_016339660.1\|668235_668373_+	hypothetical protein	NA	NA	NA	NA
WP_016339661.1\|668338_668746_+	hypothetical protein	NA	NA	NA	NA
WP_016339664.1\|670632_671595_+	AAA family ATPase	NA	NA	NA	NA
WP_016339665.1\|671607_671835_+	hypothetical protein	NA	NA	NA	NA
WP_016339666.1\|671904_672210_+	hypothetical protein	NA	NA	NA	NA
WP_016339667.1\|672212_672368_+	hypothetical protein	NA	NA	NA	NA
WP_016339668.1\|672345_672687_+	hypothetical protein	NA	NA	NA	NA
WP_016339669.1\|672695_673376_+	DUF3164 family protein	NA	NA	NA	NA
WP_016339670.1\|673347_673734_+	DUF1018 domain-containing protein	NA	NA	NA	NA
WP_016339671.1\|673726_674023_+	hypothetical protein	NA	NA	NA	NA
WP_016339672.1\|674024_674231_+	hypothetical protein	NA	NA	NA	NA
WP_016339673.1\|674230_674815_+	hypothetical protein	NA	NA	NA	NA
WP_016339674.1\|674824_675391_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_016339675.1\|675400_675589_-	hypothetical protein	A0A2H4J069	uncultured_Caudovirales_phage	5.9e-05	51.9
WP_016339676.1\|675990_676761_+	SHOCT domain-containing protein	X5JB37	Clostridium_phage	1.9e-33	38.3
WP_016339677.1\|676803_677031_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_016339678.1\|677049_678057_+	hypothetical protein	NA	NA	NA	NA
WP_016339679.1\|678183_678564_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_016339680.1\|678553_679819_+\|terminase	PBSX family phage terminase large subunit	S5MC58	Brevibacillus_phage	2.7e-133	57.1
WP_051113008.1\|679973_681065_+\|portal	phage portal protein	W8ECU7	Geobacillus_phage	3.4e-20	32.8
WP_016339682.1\|681061_681799_+	hypothetical protein	NA	NA	NA	NA
WP_016339683.1\|681830_683609_+\|capsid	phage major capsid protein	NA	NA	NA	NA
WP_016339684.1\|683660_684170_+	hypothetical protein	NA	NA	NA	NA
WP_016339685.1\|684166_684667_+	hypothetical protein	Q7Y5T8	Haemophilus_phage	3.8e-06	31.5
WP_016339686.1\|684669_684999_+	hypothetical protein	NA	NA	NA	NA
WP_016339687.1\|684991_685486_+	hypothetical protein	NA	NA	NA	NA
WP_016339688.1\|685486_686527_+	hypothetical protein	NA	NA	NA	NA
WP_016339689.1\|686526_686925_+	hypothetical protein	NA	NA	NA	NA
WP_016339690.1\|686924_687308_+	hypothetical protein	NA	NA	NA	NA
WP_016339692.1\|689719_690334_+	hypothetical protein	NA	NA	NA	NA
688883:688900	attR	NA	NA	NA	NA
WP_016339693.1\|690346_690670_+	hypothetical protein	NA	NA	NA	NA
WP_016339694.1\|690672_691605_+	hypothetical protein	NA	NA	NA	NA
WP_016339695.1\|691558_692143_+	hypothetical protein	NA	NA	NA	NA
WP_016339696.1\|692142_692493_+	hypothetical protein	NA	NA	NA	NA
WP_016339697.1\|692473_693571_+\|plate	baseplate J/gp47 family protein	A0A2H4J8D2	uncultured_Caudovirales_phage	1.7e-19	28.5
WP_016339698.1\|693579_694200_+	hypothetical protein	NA	NA	NA	NA
WP_041461231.1\|695290_695548_-	hypothetical protein	NA	NA	NA	NA
WP_016339701.1\|695610_696273_+	DUF4376 domain-containing protein	A0A0E3U2P7	Fusobacterium_phage	1.4e-08	33.3
WP_016339702.1\|696727_697099_+	hypothetical protein	NA	NA	NA	NA
WP_016339703.1\|697085_697538_+	DUF1353 domain-containing protein	A0A291AXJ8	Shigella_phage	1.4e-07	35.1
WP_005899843.1\|697547_698003_+\|holin	phage holin family protein	S6AVT9	Thermus_phage	1.3e-13	36.8

DBSCAN-SWA_2

1041785 : 1048767

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_008700457.1\|1041785_1042259_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.0e-25	47.6
WP_005909206.1\|1042536_1043250_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	3.2e-43	42.8
WP_008797838.1\|1043284_1044628_+	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	8.5e-53	31.8
WP_008797837.1\|1044832_1045852_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SQF5	Cyanophage	7.3e-65	43.2
WP_016339793.1\|1045839_1046751_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	4.1e-19	35.4
WP_187146773.1\|1046785_1046962_+	hypothetical protein	NA	NA	NA	NA
WP_008797834.1\|1046931_1047228_+	hypothetical protein	NA	NA	NA	NA
WP_016339794.1\|1047252_1048767_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	4.0e-59	42.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_021281

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection