CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021721	Lacticaseibacillus paracasei, complete sequence	7 crisprs	DinG,WYL,DEDDh,csa3,cas3,RT,csn2,cas2,cas1,cas9	0	4	9	0
NC_021722	Lacticaseibacillus paracasei plasmid pLOCK919, complete sequence	1 crisprs	NA	0	2	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_021721_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021721_1

263226-263370

Orphan

Consensus_repeat	Method
GGGGTCCTTATGAGCAGGTTTCTGCGCCTGTTTGCGCGTTTCGAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021721_1

>merge|NC_021721|1|263226-263370|CRISPRCasFinder
GGGGTCCTTATGAGCAGGTTTCTGCGCCTGTTTGCGCGTTTCGAAAGTAGAGCATAAGCGGCCCCAAGCCTAAATGGCCGGGCTTTGGCATTTAGGCTTGGGGTCCTTATGAGCAGGTTTCTGCGCCTGTTTGCGCGTTTCGAAA

>NC_021721|1|1|263226-263370|CRISPRCasFinder
GGGGTCCTTATGAGCAGGTTTCTGCGCCTGTTTGCGCGTTTCGAAA	GTAGAGCATAAGCGGCCCCAAGCCTAAATGGCCGGGCTTTGGCATTTAGGCTT
GGGGTCCTTATGAGCAGGTTTCTGCGCCTGTTTGCGCGTTTCGAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_021721.1\|WP_003563026.1\|264601_265360_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_021721.1\|WP_003568838.1\|267097_267430_+\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003568836.1\|252852_254205_+\|gluconate-permease	unknown	unknown	gnl\|CDD\|129873
NC_021721.1\|WP_003563007.1\|254451_254796_+\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003563036.1\|267720_268320_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NC_021721.1\|WP_003568841.1\|277529_277844_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NC_021721.1\|WP_003563011.1\|255585_256383_+\|metal-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224033
NC_021721.1\|WP_003563030.1\|266245_266989_+\|DUF975-family-protein	unknown	unknown	gnl\|CDD\|227810
NC_021721.1\|WP_004562160.1\|257298_258180_-\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NC_021721.1\|WP_003563017.1\|258176_259976_-\|oligoendopeptidase-F	unknown	unknown	gnl\|CDD\|341071
NC_021721.1\|WP_003563040.1\|269715_271263_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NC_021721.1\|WP_003563019.1\|260104_261199_+\|LCP-family-protein	unknown	unknown	gnl\|CDD\|181811
NC_021721.1\|WP_003563013.1\|256450_257302_-\|metallophosphoesterase-family-protein	unknown	unknown	gnl\|CDD\|223695
NC_021721.1\|WP_003563042.1\|271422_272163_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_021721.1\|WP_003563024.1\|263470_264157_-\|hydrolase	unknown	unknown	gnl\|CDD\|270620
NC_021721.1\|WP_013245369.1\|268397_269336_-\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NC_021721.1\|WP_003563002.1\|251099_252668_+\|gluconokinase	unknown	unknown	gnl\|CDD\|130381
NC_021721.1\|WP_003563009.1\|254869_255589_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213202
NC_021721.1\|WP_003563021.1\|261349_262729_-\|branched-chain-amino-acid-transport-system-II-carrier-protein	unknown	unknown	gnl\|CDD\|283235
NC_021721.1\|WP_003563028.1\|265444_266227_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154

Protein	Function_ID	Function_description	E-value
NC_021721.1\|WP_003563026.1\|264601_265360_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	4.33431e-57
NC_021721.1\|WP_003568836.1\|252852_254205_+\|gluconate-permease	gnl\|CDD\|129873	TIGR00791, Gluconate_permease, gluconate transporter. This family includes known gluconate transporters of E. coli and Bacillus species as well as an idonate transporter from E. coli. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	4.50632e-167
NC_021721.1\|WP_003563036.1\|267720_268320_-\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	6.78672e-47
NC_021721.1\|WP_003568841.1\|277529_277844_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.32335e-29
NC_021721.1\|WP_003563011.1\|255585_256383_+\|metal-ABC-transporter-permease	gnl\|CDD\|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	1.10945e-41
NC_021721.1\|WP_003563030.1\|266245_266989_+\|DUF975-family-protein	gnl\|CDD\|227810	COG5523, COG5523, Predicted integral membrane protein [Function unknown].	5.48812e-07
NC_021721.1\|WP_004562160.1\|257298_258180_-\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	5.68511e-110
NC_021721.1\|WP_003563017.1\|258176_259976_-\|oligoendopeptidase-F	gnl\|CDD\|341071	cd09608, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and includes oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid. This PepF family includes Streptococcus agalactiae PepB, a group B streptococcal oligopeptidase which has been shown to degrade a variety of bioactive peptides as well as the synthetic collagen-like substrate N-(3-[2-furyl]acryloyl)-Leu-Gly- Pro-Ala in vitro.	0
NC_021721.1\|WP_003563040.1\|269715_271263_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.45525e-169
NC_021721.1\|WP_003563019.1\|260104_261199_+\|LCP-family-protein	gnl\|CDD\|181811	PRK09379, PRK09379, LytR family transcriptional regulator.	1.41929e-91
NC_021721.1\|WP_003563013.1\|256450_257302_-\|metallophosphoesterase-family-protein	gnl\|CDD\|223695	COG0622, COG0622, Predicted phosphoesterase [General function prediction only].	2.75673e-13
NC_021721.1\|WP_003563042.1\|271422_272163_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	2.73561e-07
NC_021721.1\|WP_003563024.1\|263470_264157_-\|hydrolase	gnl\|CDD\|270620	cd14667, 3D_containing_proteins, Non-mltA associated 3D domain containing proteins, named for 3 conserved aspartate residues. This family contains the 3D domain, named for its 3 conserved aspartates, including similar uncharacterized proteins. These proteins contain the critical active site aspartate of mltA-like lytic transglycosylases where the 3D domain forms a larger domain with the N-terminal region. This domain is also found in conjunction with numerous other domains such as the Escherichia coli MltA, a membrane-bound lytic transglycosylase comprised of 2 domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, corresponding to the 3D domain and Domain B is inserted within the linear sequence of domain A. MltA is distinct from other bacterial LTs, which are similar to each other. Escherichia coli peptidoglycan lytic transglycosylase (LT) initiates cell wall recycling in response to damage, during bacterial fission, and cleaves peptidoglycan (PG) to create functional spaces in its wall. PG chains (also known as murein), the major components of the bacterial cell wall, are comprised of alternating beta-1-4-linked N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and lytic transglycosylases cleave this beta-1-4 bond.	2.76198e-08
NC_021721.1\|WP_013245369.1\|268397_269336_-\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	6.19632e-32
NC_021721.1\|WP_003563002.1\|251099_252668_+\|gluconokinase	gnl\|CDD\|130381	TIGR01314, gntK_FGGY, gluconate kinase, FGGY type. Gluconate is derived from glucose in two steps. This model describes one form of gluconate kinase, belonging to the FGGY family of carbohydrate kinases. Gluconate kinase phosphoryates gluconate for entry into the Entner-Douderoff pathway. [Energy metabolism, Sugars].	0
NC_021721.1\|WP_003563009.1\|254869_255589_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213202	cd03235, ABC_Metallic_Cations, ATP-binding cassette domain of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.	5.1545e-66
NC_021721.1\|WP_003563021.1\|261349_262729_-\|branched-chain-amino-acid-transport-system-II-carrier-protein	gnl\|CDD\|283235	pfam05525, Branch_AA_trans, Branched-chain amino acid transport protein. This family consists of several bacterial branched-chain amino acid transport proteins which are responsible for the transport of leucine, isoleucine and valine via proton motive force.	7.36575e-108
NC_021721.1\|WP_003563028.1\|265444_266227_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	5.11135e-36

>NC_021721.1|WP_003563021.1|261349_262729_-|branched-chain-amino-acid-transport-system-II-carrier-protein
MSPQPTLTKRQYLTLGSLLFGMFFGAGNLIFPIHMGQLAGSAWLPAAIGFLLSAVLLPLLSIMAISLTRASSMYDLARPAGHSFALFFLLATHASLGLLIASPRTATVTYSIGIAPFLGKDQQQIGLLIFSFIFFLTTFLLARNESKITTYIGKLLNPLLLILLAVIFFWALVIKGDIRAISFTSSPKLMSSNLINGFLQGYNTMDALAGLGFGVTIITALKLMGLHQASTRAKAVAKVGSLAMGLEALIYMLLILLGAISLGFSKLTANGGTAFNQIMTHYTGLIGTALLGAMTLLACLTTAIGLVTSFSQDLGHRFPKLGYHFFLPMTTIGAFLIANFGLDQIIAYSTPILMLLYPLAIALIMLGLMHPWIGKNTRIYKTTVAFTMIPALLDAIHALPAGLAQLPIFSSIQQFATTYIPWFGIGMDFVPFLLIGFLTGFIAAKLSGHKLAPDLPDPD
>NC_021721.1|WP_003563019.1|260104_261199_+|LCP-family-protein
MDKQPDSDQQTLKRKPKRRHPILRALAIIALVALFLAGGYAARFYSQAKKAVAKTYDPVSTKAVSSDLDGKKPISILLLGTDTGAFGRKDTGRSDTMMLVTINPKEKKTTMTSIPRDTLAEMVGTGSDSPTYEKINAAYAYGQSDAAIKTVEKLLDVPINYYVTVNMAGLSKIVDAVGGVDVNVPFSWTDWNTGGQTFKKGKAHLDGGMALAYARMRDEDPEGDYGRQKRQQEVINQIVKHLLSVKSLTNYQKVMDSLSSSMRTNLTFDDMMAIAQNYRASATTIDRQQLKGIGVYIDEAAYQVMTTETLQKMSNELRGQLGLESKTLSNFNTQQNEINNANGFDWTANNPVYTVSLDGATTGP
>NC_021721.1|WP_003563017.1|258176_259976_-|oligoendopeptidase-F
MQHLPARAEVPTELTWDLTTIYPDDKAWQVDFEAVRQQAKEAAALKGTLGKSPEALVAGIKAVLAVFRRFEKVYVYSSLKSDQDTGNAAYQAMNAKAESLAADLASQLAFMDPEILAIPADQLTAWRDTESLKPYGHFIDAITVNRQHVLTTAAESLIASAGDALNASHATFNVLNNSDLQFGFVENEDGETVQLSNGLYGQLIRSTNRKLRKDAFEALLRAYESLKNTFAQTLSGQIKAHNFNALAHHYPDARAAAMASNHIPESVYTTLLDQVNAHLPLLHRYIALRKKILNVDQLHMYDIYTPLTGRPPLSFTLDQAKDEALKALAPLGNDYLDHMREIFNNRYIDVVENKGKRSGAYSGGAYDTNPFILLNWHDAVDELYTLVHETGHSVHSWYTRHHQPYVYGDYPIFVAEIASTTNENLLTDYFLKNTNDPKVRAYILNYYLDGFKGTVFRQAQFADFEHWIHQQDQHGEPLTATSMSSYYADLNARYYGPDVARDPEIAFEWARIPHFYYNYYVYQYATGFAAASTLAAGISGGEPEAVSRYIGYLKSGSSKYAIDTMKAAGVDMTKPDYLEAAFSLFEQRLAELEKILQKG
>NC_021721.1|WP_004562160.1|257298_258180_-|NAD(P)-dependent-oxidoreductase
MSSVKLGFIGTGVMGTGIIKNFLKNGQEVVVFNRTQAHAQPVIEAGATWAESPHAVAAQCDIVLSMVGFPQDVETIYFGSDGILAGARKGALLIDMTTSTPTLAKKIAAKAAEKGLQAVDAPVSGGDIGAKNGTLTIMVGGDKTLLSRLQQLFAPIAASVNYFGPAGSGQHAKMANQIMIAGTMTGLTEMLVYAKAAGLDLDETLKVVGGGAGANWSLSNYGPRILQGDYTPGFFAKHFLKDLRIALDEADNMHLQLPATQLAKQLYEQMVNTGKGNLGTQGLITMNDRWDQA
>NC_021721.1|WP_003563013.1|256450_257302_-|metallophosphoesterase-family-protein
MTTIAILSDIHGNMTAFSAVIQDAKAHQADEYWFLGDLFLPGPGSDKLWATLHGLKPTHIVKGNWDDDLFWVLDGPVDLSQPTDVYFSRLVAYLWPHLTAENLATIRNWPLHEVFEQDGLIVSLAHNLPDKNQGHALYPDQPQLNFDQIAPDSQIDLAVYGHTHQQLLRYTSNGQVILNPGSIGQAYSPRPHLQTTTYADYALLQLNDGAITDLDLRQVPYDVSAELSLAKQQQLPYPEVYTKLRHTGATSTHNAAYLKQFEQRHDYQQEVAEFLHKYRHQHY
>NC_021721.1|WP_003563011.1|255585_256383_+|metal-ABC-transporter-permease
MNLFAYAFMQNAFMASTFIAITTGIVGVFVVARNMSFLAHTLSEVGFAGAAFAVFAGIRPLDGMLLFTAISSISVGRMSVQASRREASISAVSSLFIGLGILFLSLSSANASYATTILFGSIIGISRADVWQLVALAAGVLVTLYFGYRRLAFDSFDPVGSAAQGLKSKYISIYFLLILAVSVSIGAQIVGSLLVFILLTLPPNVAKYLGRTLPQMIVISVITALIGVWSGLYLGFLTNWPVTFFIAAIEFLFYFLALWYHHRTN
>NC_021721.1|WP_003563009.1|254869_255589_+|ATP-binding-cassette-domain-containing-protein
MSEPILTVNHLSFGFRDQQLYQDLSFQLNVGSMTSLVGPNGVGKTTLIRLLMAQLKPQAGTIRFRQQPPVRLGYVPQFRNVDTEFPLSIRSFIQLRQLDHLFFWHTGKEKAALDAVIKATHLGKIADTRLGMASGGEKQKAYLAQALLDDPNFLILDESTASLDVNTKQELMDLVQELNQTRQLTVLFVTHDLSLAKKYTQQYLLLTGSSYEMKPTAQMDLKAMPEELRNDAENRGVIA
>NC_021721.1|WP_003563007.1|254451_254796_+|hypothetical-protein
MYEPTKKRRVAEDVAKVFPKEVTNQIFDVIAVMNKAKQIVTAPVAIAFSDDYTDDEMYAMIIQGNLAPAQEFPLTYAGEKPFLGHGYILVVKDKPKTIRLDFSTANPFKAEESK
>NC_021721.1|WP_003568836.1|252852_254205_+|gluconate-permease
MDILVLVLGILLLLVLIIKFKFNTYVSLIITAVVVALGLGMAPAKIATSIQNGIGAQLGELALVFGFGAMLGRLVADAGGAYRIAHTLINAFGRRGLQLAVVLASFIIGIALFFEVGIVLLVPIVFAIAAEAGVPILTLGIPMAAALSVTHGFLPPHPAPTAISTALGASAGLVLAYGVIIAIPTVYIAGPLFSKLAHRFVPDAFERRGNLKALGPQKTFKLEETPSFGISVLTSLFPVILMAIATVYELVFHGGKLPKTPNGLDNVIAFIGSPSIAMLISLLFAMWAMGYARKLPAKAIMTTLEDAVKSIAMLLLVIGGGGAFKQVLIDGGVGDSVKNLFVGSGISPLILGWLIAVVLRIALGSATVAAMTASGLVLPLMQSAGIQPALMVLAIGAGSLAASHVNDAGFWMFREYFDLTIKQTLLTWTLLETIISVVGLGGVLLLSLVV
>NC_021721.1|WP_003563002.1|251099_252668_+|gluconokinase
MAIKYMIGVDLGTTSTKVVLFDLKGHAIATANNPYPLYQDTPDMAEEDPEEIFAATVGGLTEVMHRGNVQPDELGGVSFSAAMHSLILMDENDKPLTRVITWADNRAAAYATKLKQSDLGMTLFKNTGVPTHPMSPLVKLLWLSAEHPELVAQTSHFIGIKDFILFRFFGRYVQDYSLANATGLFNIHTMDWDDRALDVANVRRDQLPELVDTSYQLTGLNANYAAVTGIDAKTPFILGASDGTLSNLGVGAIDPGVLAVTIGTSGAVRVVTDKPVVDPQGRLFTYYLSPNHWVVGGPVNNGGIVFRWVRDQLFAPEKLTAEQLQVDSYEILTEIASKIPAGADGLLFHPYLGGERAPIWDANARGSFFGLTRQHTRAHMVRAALEGIVYNLYMVMLMIEGITGKPKAIQATGGFARSALWRQMLADVFEQEVNIPESFESSALGAVVLGMKSLGLIDDLNVVKDMIGVTNTHEPNADNFQAYRELLPIWIRLTRKLGSEYQAIADYQRAHPDPNAHIAAED
>NC_021721.1|WP_003563024.1|263470_264157_-|hydrolase
MASNHSQKVEAIADHADADNDSSHVNAKSIVLSNEAKVEQANAHSLINPKKEITFTVGTNDIAEAAHQIADQKAAAAKAAEEQAAAEQAAAEQAAAEQAAAEKAQQEAQQAAQNAAAASAASAASASSSAATTASTETTTNKGTFKLSFYDPSVLGSGLGYGGVAANLSVFPKGTRLKITLSDGTVWYRTVNDTGSFAAGNPNQLDVAMPNSQIPSAGVLTATVEVVG
>NC_021721.1|WP_003563026.1|264601_265360_+|DeoR/GlpR-transcriptional-regulator
MAMYREKRFEEIKKLLAARSELSIEDIMKAVGVSRDTARRDIVALDAQGVARRTRGGLVSLSFGHTIPSYSARLKRFSTQKTKMAKSALTLIKPGGVYFIDDSTTLLKLSQSIRQPVTVYTHSLDNAIALSVEERVNLHLFGGKLDHHARFFFEPTMLETLRRIAFDAAFIGATAIAEDGVYFSYMEDAQVKQAAALSARRVVVVSETEKFQIEAPYRGLELGQITTLITDKKLSQTHKQWFAPQTQFLLGD
>NC_021721.1|WP_003563028.1|265444_266227_+|glycosyltransferase-family-2-protein
MVKPLVTIIVPVYNLEAYVAHGLKSLIEQTYSHLQIIVIDDASKDHSPQIIAHFAELDSRIQPILKQVNHGVSAARNSGLALAKGDLVAFMDGDDWYEPDFIAHAVDMMARGWDLIAMPFYRDDPDPRPVHEALRKPKQLTREGLIRQMLHPIGYIRGYLWNKVFRRDVIEQVRLRFDESMTIMEDELFTATYVMATHRFLYTGHPAYHHVVRRDSATQSLGIIGAVPQQLYALWRIHQVLRVARRTEKVTKKEAIKIEH
>NC_021721.1|WP_003563030.1|266245_266989_+|DUF975-family-protein
MTEHLMTYRQLKQKAKGQLKEGTNRRDLMLAYLLPSLIQAAVAIITYLMVFALIQKFGIDKALTDPDGFQNYLQSGNRTGSMNTIQSLVNTMLIQGVNFGVLDLVRRKERVQPLHALLGLFNGQWFWGAISLWIFMYFLTLMGLSFFLIPGILLALGWRQAFWVFKDGHETNQRFSSISALIGSWRLMRGFKGDLLGLYVSMIGWYLLENITFHLFDWVINPYLQLVHANYYENRRAYKIAAQAAQS
>NC_021721.1|WP_003568838.1|267097_267430_+|hypothetical-protein
METEAYMTLAEVKARQAALKDKVPLDQAIAENIQNWAQWLLDEGFEGSYFTAKIDGDTINITDLDGHPAASISTDAPSYVEAFKDSDRMTMMAIQTKLRRLIDRQVLKSQ
>NC_021721.1|WP_003563036.1|267720_268320_-|signal-peptidase-I
MKNNSHSTLKTVLEFLVLFAVIFFASQLLMRYVLSKDVVQGTSMQPTLENGDRLYSIRVKKPKRNDIVVINAPDRPGSLYIKRVIGMPGDTVSSKDNQLSVNGKKIAEPYLNKKFATDEINKWASQQGLDASTIKFTNDFNIKTLSSTKSAKVPAGKYFVMGDNRLVSHDSRDFGFVDKSKIQSVVVWRYWPLNQMKLY
>NC_021721.1|WP_013245369.1|268397_269336_-|ADP-ribosylglycohydrolase-family-protein
MGIMESRLIHGTVGFAIGDALGLPVKGQNAAELTAAPVTTMKGYGTFNQPAGTYSDETGLALAGLDALQHGFDEQALIKAYQAWFTAGKYAPYGKRSPDIWPSIETALKTGQSVASPKEPGALIRILPFAFFAYQTFDTSLFQKAEGVKVLETFVHITNQDAENLVAAGIYMQIAVELLGATPDLPSAIATGTDKAGSYFGTTQPYQPIFEAFQAALADDKWPDESATDPISLLARTLKALQSKPDYHDAVLQTVNQGGATDTTGALVGGLAGLAYGYTSLPHRWCLMLAEYAQIVDLCRQAENSGFFPKYD
>NC_021721.1|WP_003563040.1|269715_271263_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MSVLTVTGLSQRFLDKVLYQDASFQVNIEDHLGVIGQNGVGKSTLIKILTGTLTPDAGKIVWQKHLHVGYLDQYANLVPGQTVIEFLRTAFSDLYRKEAKMNQIYADYANHPDDDLLAKAGELQQELEAGDFYDLETTIQTVAEGLGITAMGMDHPVEALSGGQRSKLILAKLLLEKPDMLLLDEPTNYLDVSHIAWLTDWLQNFEGAFIVISHDFDFLENVTNAVLDIEFGQITKYTGTLKQAMRQKEADHETYLKAFAKQQETIKKTEAFIRKFKAGTRATMAKSREKQLARMDKLTPPGTRSKAHLAFPYAPVNRQILVDVNDLVVGYDKPLLQPMNFSVAKDQIIAFEGFNGVGKSTLLKTLLGLLPAISGNVEIADNVVFGYYEQELHWDQPKQSPVQYLEQRFPALTQKTVRQVLSRTALTSEEANNPLTMLSGGEQAKVKLADLMLQTTNILVMDEPTNHLDDDTKNALREGLQQYPGAVLLVSHEAGFYDSSWVDTVVNVEQLQVKA
>NC_021721.1|WP_003563042.1|271422_272163_-|class-I-SAM-dependent-methyltransferase
MTEDQAFWNAFAPDYAAAEQASRLPIAHDVIAWLRSTQLLPAHSAVDLAAGTGRYAVQMMPWVQELTLIDWSSAMLAFAKERMHQQADTKAQFIVADWRKLHKPLNADMLFVSQLPTLKPQDLKMLMNWANQTVVLNFQTAQSDALLEQAASLLGLQLPPVYQADPARMTSFKVWLTAQRIPFQSHSLTYEIEEQTTLSDLLPDLATPIGLKTAASLAKTITGHENTHVQVTDRLTYTYTQLVWHV
>NC_021721.1|WP_003568841.1|277529_277844_+|thioredoxin-family-protein
MAIEATKDNLKALTAEGTVVVDFWAPWCGPCKVLDPMLTALEQELPALKVVRYNVEKDHTLPSTMGIMSVPTLVIYQQGEAREKVTGVYPKDKLKRYFEQKLEA

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Crispr_ID: NC_021721_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021721_2

710092-710200

Orphan

Consensus_repeat	Method
GGTCCTTACACGTAGGTTTCTGGTCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021721_2

>merge|NC_021721|2|710092-710200|CRISPRCasFinder
GGTCCTTACACGTAGGTTTCTGGTCTGGCGAACGCGTTTCGGAGTCGCACAAGTAGACCGATCTTTGGCCACTTAGGATTGAGGTCCTTATACGTAGGTTTCTGGTCTG

>NC_021721|2|2|710092-710200|CRISPRCasFinder
GGTCCTTACACGTAGGTTTCTGGTCTG	GCGAACGCGTTTCGGAGTCGCACAAGTAGACCGATCTTTGGCCACTTAGGATTGA
GGTCCTTATACGTAGGTTTCTGGTCTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021721.1\|WP_013245473.1\|705761_707489_-\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_013245468.1\|697623_699621_+\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|173886
NC_021721.1\|WP_003587307.1\|723617_724334_+\|trehalose-operon-repressor	unknown	unknown	gnl\|CDD\|274116
NC_021721.1\|WP_003563577.1\|709117_709942_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180840
NC_021721.1\|WP_013245472.1\|702522_704544_+\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|173886
NC_021721.1\|WP_013245477.1\|714387_715044_+\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_016386810.1\|715057_716194_+\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003573839.1\|718420_720139_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_021721.1\|WP_013245480.1\|717299_717983_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226381
NC_021721.1\|WP_003583596.1\|700460_701162_+\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
NC_021721.1\|WP_003662794.1\|720143_721925_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_021721.1\|WP_003563571.1\|704619_705594_-\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NC_021721.1\|WP_013245479.1\|716234_717272_+\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003563579.1\|710323_711196_-\|methylenetetrahydrofolate-reductase-[NAD(P)H]	unknown	unknown	gnl\|CDD\|273212
NC_021721.1\|WP_020751477.1\|707475_708270_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_021721.1\|WP_003573843.1\|722086_723331_+\|OFA-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340911
NC_021721.1\|WP_020751478.1\|708521_709070_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|227064
NC_021721.1\|WP_013245470.1\|701313_701673_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	unknown
NC_021721.1\|WP_013245471.1\|701656_702358_+\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
NC_021721.1\|WP_013245476.1\|711173_713459_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|235367

Protein	Function_ID	Function_description	E-value
NC_021721.1\|WP_003573839.1\|718420_720139_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.67941e-147
NC_021721.1\|WP_013245468.1\|697623_699621_+\|WxL-domain-containing-protein	gnl\|CDD\|173886	cd01951, lectin_L-type, legume lectins. The L-type (legume-type) lectins are a highly diverse family of carbohydrate binding proteins that generally display no enzymatic activity toward the sugars they bind. This family includes arcelin, concanavalinA, the lectin-like receptor kinases, the ERGIC-53/VIP36/EMP46 type1 transmembrane proteins, and an alpha-amylase inhibitor. L-type lectins have a dome-shaped beta-barrel carbohydrate recognition domain with a curved seven-stranded beta-sheet referred to as the "front face" and a flat six-stranded beta-sheet referred to as the "back face". This domain homodimerizes so that adjacent back sheets form a contiguous 12-stranded sheet and homotetramers occur by a back-to-back association of these homodimers. Though L-type lectins exhibit both sequence and structural similarity to one another, their carbohydrate binding specificities differ widely.	3.44354e-22
NC_021721.1\|WP_003563577.1\|709117_709942_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180840	PRK07105, PRK07105, pyridoxamine kinase; Validated.	1.54617e-67
NC_021721.1\|WP_013245472.1\|702522_704544_+\|WxL-domain-containing-protein	gnl\|CDD\|173886	cd01951, lectin_L-type, legume lectins. The L-type (legume-type) lectins are a highly diverse family of carbohydrate binding proteins that generally display no enzymatic activity toward the sugars they bind. This family includes arcelin, concanavalinA, the lectin-like receptor kinases, the ERGIC-53/VIP36/EMP46 type1 transmembrane proteins, and an alpha-amylase inhibitor. L-type lectins have a dome-shaped beta-barrel carbohydrate recognition domain with a curved seven-stranded beta-sheet referred to as the "front face" and a flat six-stranded beta-sheet referred to as the "back face". This domain homodimerizes so that adjacent back sheets form a contiguous 12-stranded sheet and homotetramers occur by a back-to-back association of these homodimers. Though L-type lectins exhibit both sequence and structural similarity to one another, their carbohydrate binding specificities differ widely.	9.96558e-25
NC_021721.1\|WP_003662794.1\|720143_721925_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.04053e-161
NC_021721.1\|WP_013245480.1\|717299_717983_+\|hypothetical-protein	gnl\|CDD\|226381	COG3863, COG3863, Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown].	2.50052e-17
NC_021721.1\|WP_003583596.1\|700460_701162_+\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	5.43523e-23
NC_021721.1\|WP_003563571.1\|704619_705594_-\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.24486e-25
NC_021721.1\|WP_003563579.1\|710323_711196_-\|methylenetetrahydrofolate-reductase-[NAD(P)H]	gnl\|CDD\|273212	TIGR00676, 510-methylenetetrahydrofolate_reductase., 5,10-methylenetetrahydrofolate reductase, prokaryotic form. The enzyme activities methylenetetrahydrofolate reductase (EC 1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC 1.7.99.5) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in bacteria, and currently designated 1.7.99.5. This protein is an FAD-containing flavoprotein. [Amino acid biosynthesis, Aspartate family].	2.85486e-110
NC_021721.1\|WP_020751477.1\|707475_708270_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.61376e-84
NC_021721.1\|WP_003573843.1\|722086_723331_+\|OFA-family-MFS-transporter	gnl\|CDD\|340911	cd17353, MFS_OFA_like, Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.64808e-111
NC_021721.1\|WP_020751478.1\|708521_709070_-\|ECF-transporter-S-component	gnl\|CDD\|227064	COG4720, COG4720, Predicted membrane protein [Function unknown].	7.72099e-13
NC_021721.1\|WP_003587307.1\|723617_724334_+\|trehalose-operon-repressor	gnl\|CDD\|274116	TIGR02404, Trehalose_operon_transcriptional_repressor, trehalose operon repressor, B. subtilis-type. This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions].	1.84618e-92
NC_021721.1\|WP_013245471.1\|701656_702358_+\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	2.0601e-11
NC_021721.1\|WP_013245476.1\|711173_713459_-\|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	gnl\|CDD\|235367	PRK05222, PRK05222, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional.	0

>NC_021721.1|WP_003563577.1|709117_709942_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MNTKSLIISQDLCGVGQVSMSVALPLAAGLGLTPYVLPTALLSSHTGGLGANTYLDLSAEMPGILKHWQQLQLQPDGIYLGYLGQKAADQWDRWLPKFHAPLVLIDPVMADNGKLYKGFDAAYVATMQQLAHRATVLTPNITEAQLLLDEKPTTLTDPSAVTALAKRLHAQFDSAVLITGVPFHKQIAVVGIDASGTTLALAQPKETGHYFGTGDLFAAALATGLLKGQNLRQAAATGMVAARLAIKATLATDADPKYGLNLAGVIPALSKQLP
>NC_021721.1|WP_020751478.1|708521_709070_-|ECF-transporter-S-component
MQTSHNTLKNIIFTGLFAAIIFIGISLLRIPIPAMVGRPFIHFGNPLMVLAILFLGGRLGGLAAVIGLGGFDLLNGYAATSWLTALEAIVMAIVVSALVKAFKHNDQPCNIIIIGILAGLTKIVTSYLTGVVEALMVGSVFKAAVVGAFLSLPATVINSIATAIIVPVLYFILRPLFRRFTN
>NC_021721.1|WP_020751477.1|707475_708270_-|ABC-transporter-ATP-binding-protein
MAEPIVTLSHIQKSFGSKEVLKDLNFKISPGSIVGYIGPNGAGKSTTVKMMLGLMQPDGGTIELFGQPIKPNDPSYKRRIGYVPESADVFDALTAREYLSLIGQLYGLSAADAEQKAFALADLVNLREAFDRRISSYSKGMRQLILIIASLLHNPDILFWDEPLNGLDANTVLVIEEVLQDLRDRGKTIFYSSHILDVVQKLSDRIIVLNDGMVVADGPFKSIAKEADTNLQQLFNDLTGFAEHGQKAQSFVDIVTGGESHETI
>NC_021721.1|WP_013245473.1|705761_707489_-|hypothetical-protein
MKLFKKTSLDTADPTDTAALPLPKTFAWLARFRPLLEKRGIQFDQLRLILATKGLLAARESSGLGSMFNKRKRGQDASIKTAFLWNLFFGLILGLLMFLPTSILTTFTLFMTIQLLTSFLAILTTYSSLILDPRDRSVFASRGVNDQTLSFARLINICFYLGMTLLAMGGPGLVMAGIHYGPVVALGGLIGLLLSGVLSLVMALFVYLLVLRFFDGERLRNMLNLVQILLMIGIYVGGQLPNLLPRSMSLFGMSISGQFNWLFLPAVPAWFVGLPMLFAGQVTVLSLTLTALSVVVPIALTLIFLHFSGVFEAYLEKLNQGDARTRKLGWWFRGVSALLTRPGEERTYFTLGWRVLGSERDYKLRVYPQLAYGIILPLIFVGGGLRDMPFSSAKHFIAYAGIGVIVALAPALVNLRFSSQPQAMAIFQYVPFTTHGLLLRGVVKAMFARLFLPPLLFITILTTALGGFDALLAGIAVIIFTYGMTLMMGWPLVGSQFPFASVYSANANFSGGALGFASIFFGVIVAMIVIGIGGFLGGWLFPLGLIVLGLTLGMLLGHFYRTNLRYELKIKTTQE
>NC_021721.1|WP_003563571.1|704619_705594_-|EamA-family-transporter
MPRTEAHLARHTNQKLKGVSFAVIGAIFWGASGIFTQTLFTDAGVKPLWLVGIRLFFAGLLLLLWSGVQEPRMFLAIWKNRHDAILMIVFAFLGMVPSQLTYFLAINAGNAATATILQFLGPVFILLYVAFATHQMPRRIDFVSITLALIGTYLLVTRGHLTGLSLAPAAVFWGIMAGVSQALYTLLPRTLLAKYDARAVTGWSMLLGSLPFLPQYVLHPNPLLTLPDFGAIAFVIVFGTMFAYLLVLGSLNYISPVATGMLSAFEPLTATTLAVTRLHIAFGPAEWLGGILIILNTLLQALPFNKIHHVQQRLTRQFSQKTKS
>NC_021721.1|WP_013245472.1|702522_704544_+|WxL-domain-containing-protein
MKKRCYLLACLGMLLCTLLAPVTSVGVAVTWPTTSGYPAPPSFGDVDGLFSPTMGDSSLLTDPTSGHAVGLEINKDQANRSGAIWSKAPMFDLDKDSSYTMYFYMGNKPKSGEGMAFVLAAKPAAPTKVDTGSLGVWGVDHLPPNSKPQEVADTALPNSFAMVVDTQKNGTGDPGGYEQLSDFKSYYFGTGYPGQANMYRIDYPYWMTWLYFKIDNPSEQYRFGLGTQKNLYETPANGKWHKLQLDWKKDNLGGGTLTAKMTITRTKDPDYATEVIKWTKNDIQKYFSQGSTDPAPRKLYLGFTGTTSNVFEPHVVAIGAMPEAATVNGTVALMRGAETVEATTHLKVDDVLHYDYTVNVKATSQATWPESGTATMNVPKGKYFDYLKADGTPAKPGDTLPIKVTIGNTDYQAQGKIQPDGNQIVVTNMPQVPKGTTATVKFSLPAKVKHHGLVQTTPVQDKPIGTVTGDGQTYDLKTPAGKDFLAYILDPETGELVLEKVPSFVFELKNGQTGYRNPTVMEMVKGLPTPTATNWDQANADQWLTNQQGREPTNSTGKVLSVKDTRPTKQGWHLTMQLSPFTLTDNSYVLGDNGNKLGGKATLVLTDQTAQIAAIKDNNNATPVKNMVAGGTDWSLGTQTGNVAAYLGIEPTATAKAGQYQATATWLLTNAPK
>NC_021721.1|WP_013245471.1|701656_702358_+|WxL-domain-containing-protein
MKIVTNFAIAFVTLMLAGFVGPHQSVMAADDLGPKKSSAQLTVDAGNIMIQQVPDLNFGGISVHEIVSGSFQRHPLKSNLVNPGPIKTATNANDGNATGLLQIADYRGTGAGWRLEAKMDAMTDGKGHFLAGYVDLVGSQLTASNPDINPINPAGSNVPRLNFAKDNTSVSSTVVWQADAETGAKPGQGQGDNQATIGTGTALTLVATNTNVTIAKGRYQGAITWTLSNAPKG
>NC_021721.1|WP_013245470.1|701313_701673_+|LPXTG-cell-wall-anchor-domain-containing-protein
MTRSIWRFLISLIIVFGVLGEGIMAAHQVRAATSIGEVVVIDDRPKPDKDHNAPGTEVSKPKEEPSVPPRQQVDRLPQTSEGGQTWYSLIGFALLMMSSLRLQLRLKRQDRGDDDENRD
>NC_021721.1|WP_003583596.1|700460_701162_+|WxL-domain-containing-protein
MKRVNYMSAGLIAMTFAGVMLPITSVFAADEPIKKTSVGEVRVGVDPDNPDPNNPDNPDGSKDILSLVKVPDLKFKSVSVEQLATGQQTLPLTSNTVTDKPVKNEPAGNASDGNNQGLLNITDYRGTGAGWKLEAQAGELKNAAGQKLAGSLLLAGVAKTDETDNNPTAISQAELVLEGSGVQVWNAASGQGQGRNTGVFTSADTVLKLSQNTAAYGGKYQTAITWTLTNAPS
>NC_021721.1|WP_013245468.1|697623_699621_+|WxL-domain-containing-protein
MKKKTFIMICLTVIFGMVLGPLQSVAAAEATWPSGTYPAPATGSFTRLNGLFDRVSTDSSPIKSGTDEVGFELNADQASKVGSVWSKTPFVDLSKDKFTLDMQIYLGNKTGGADGLAFALAGTKPTKSGNGGASLGIWGLPEMSSGASSASVAATGTQNSFAVVVDTKKTFDSVRSGMDKAINYPIFGSTDQYIGSGYPGQAGMYKIGGPFWRTELVFTDSGTGLKNRADYLSNRVTNGSWSNLVVSWAKSANGGTLTYQLKGTNISYSIPWTNAQIQSIFGSTKLFLGFTSATGAASEPHVVGIKSLADFNTVSGTVTLKQGNDPVTIDKPLNIGDKLMYEYALDVNNIDGRPWKATNIVLPKGEYLDYLNSGGAPAKPGDNLAVNVTIGSETKTAHAIVQSDNLSAVITDMPEFPNNTESLVKFSLPVQVQKHNATTIKYVTHAAGNLTGGAPSNSYKLTNTVDNSDSVKYSIAAFDPGELSLLVVPNFYFQKLKVGEPEPVDPEVADVIAGIPGQGKLNSSSEIAPDKWLINNSQNVSAPGKYLEVKDTRPDKPGWRLSMKLSPFTHADDYVLGDNGDKGGGKAEMVLFDVNSQTDFEVTRIKDNNQDSVVKVMQAGTTEPNWSLGDAASSTQALLSVQRTPSVHAGKYSSTATWTLANAPQ
>NC_021721.1|WP_003563579.1|710323_711196_-|methylenetetrahydrofolate-reductase-[NAD(P)H]
MKINQCFKDHQVISFEVFPPRKNASNIALTPILNTLDAVKEADPDFVSVTFGANGNKPHMGTLEVAKLIKDEFDMEPVAHLPAAQLTREQVDAELRGFQDAGIDNILALRGDIPKSGRVSNDFPYACDLIEHIHQVGDFNVVAACYPEKHPESPDVVSDIHHLKEKVDSGASQLISQLFFDNQVFYRFRERAQLAGINVPIEAGIMPVINEHQIERMATMAGVNLPPKFVAMMQHFSGNKEAMRDAGIAYAIDQIVDLLVHGVDGIHIYTMDNPTVVKRIAAATQTIRNA
>NC_021721.1|WP_013245476.1|711173_713459_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase
MTTTIIGYPRIGEHRELKFATQKYFKHQITAQELQEQVKALRQHNWETVQAAGIDQIPTGDFSFFDNTLDVANLLNIVPKRYQALGLSPLDTYFAQARGYQGEAGDVKALAMKKWFNTNYHYLVPEFDQDTQIKVTDWQLFDQFEEAKALGINARPTLVGPYTLLKLSRFIDVTPDDFVTDLIAAYTDIIGRLHAAGAEWIQVDEPALVYDQTDADLALFERLYTPLLAQKQSAKVLVQTYFGDLTDSFDRISKLPFDGFGLDFVEGHANLDLLKTQGFPAGATLFAGIINGKNIWRTHYADALATIKTLAKITDKLVLSTSTSLLHVPYTLRNETHLKPEEKQYLAFAEEKLSELHELDAIFETGADHKAYQANVALFSKPRYAENKALNEKIAALTPADYTRTPERKTRLAIQAKAFKLPLLPTTTIGSFPQTAEVRRNRAKLRRHEITEEQYTAFNHKEEIEWIRFQEEIGLDVLVHGEFERNDMVEYFGENFGGFRFTDNGWVQSYGTRGVKPPIIWGDVYRTKPITVAETVFAQSQTDHLVKGMLTGPVTIYNWSFPREDLSQKTSVEQIALALEDEVLDLEKHGIKIIQIDEPALRENLPLRKKDWYPKYLDWAVPAFRLVGSKVKPETQIHTHMCYSQFGDIIKAIDDLDADVISFEAARSDFSLLDILKATHFQTHVGPGVYDIHSPRIPSKDEIVHIIHEILKRLPADHVWINPDCGLKTRDVPETKASLINMVAAAKQVRKELTHENQPVL
>NC_021721.1|WP_013245477.1|714387_715044_+|hypothetical-protein
MKKYGLVLILVLGLSPFFCKANFVHAQNFQKPIVEIMAEFQSKPKIVRTIQSVPIHVAAIRNFISKNETPVSSLDVMRSVYPGTPLSDLSSRTASFDDALTYFDHQKIKYTKTNGIPNYRIIVDELRAKRPILLKLKANTPYWPESESAILLYGIQVFPLPDGKANILYICRSLNHADQVTYSGGENNFNLLANEKQQDPTIQNIVYSWKATVYGFKK
>NC_021721.1|WP_016386810.1|715057_716194_+|hypothetical-protein
MQIFKLVLKSLTIGGGLLMLAFSPQPVCAQNLTVRSETISLQKQLLVQEKWESYVKNFLIDSGSNIQDFYLGQGFTTSTPSKTRLTNFPIIKKDNQDISYVLQIDDQDQIMVSRRLGQSLNTVSKTVSSSPQQPVNIFNSANSMYYKAAGGTPHLLIGHDPLSSDMAKLSEQKSPRSTVQLTAPLAQSHLRAKRSPIVFEHVLLPWRVYEIQHEKPWCEWYAITGVVNNLAGKKLMTAEQMLRNVYHGESIDQLIYNKEHKPRNLAESFNFLKSKYSISVMLNNGFPSFDTVKKEIKERRAPIITDLISSPSNDTHALVQVGYTASTSGRPDEHPYYYYWNPWWEDIFVVSSKAPYFQLNDKRWSIQRYQYNYSKPLE
>NC_021721.1|WP_013245479.1|716234_717272_+|hypothetical-protein
MKQLLIIVSLFVLMLVSGCVHKQQTKINYAVAVVETTATTKKSLITYYSKQLKPVKQQPLKYAALGSIWNNEIYSGGKVFLIPTGLTKMENEHKVLGIDKRNGDATSYRVDRTSIQGIAVSSSHIYTTSNLNAVNYITQVNRKSNKVKEIELPFDYVSLLMYRNGNLFVFSTNFNDIQHNRLFIYNDKLELKRKVDLAEVPQYIQKATFLNNKLVFTATFDPNEPKPAELGIVNLDSWQVSTFRLKESAANDIIAYKDKLIVANTDVVESRGKSISLIDLHSKEVTLYDLNTGVDRLALSGDTLYALGADELASFDAAHGFAIKKHIKLMFHEGLGRSALFVAKP
>NC_021721.1|WP_013245480.1|717299_717983_+|hypothetical-protein
MKKSLLFILPLALGIIAGQSQLVHAEGNLPQSYTDSTDPAKVFPKDKVDKMIQDAEQKPVLPDPGLPEHSRQKRNAGNQYPRRAGVILVTPDAYKGIPTGHAAIMRNTNSVVEALSDGVKIGHNNWDNSSASGKNRVYAVDVNATSNYQEGVVAEYCAAYKGKPYNWNFFNMDTRDSFYCSQLIRAGFLDSYKLDLNTSEFDAPFGKVMHPIEFVNSDKTTLIYRRG
>NC_021721.1|WP_003573839.1|718420_720139_+|ABC-transporter-ATP-binding-protein
MRVLFPYIKKYRWDVIWSVLAILIVAFATLWQPHLLQVIMNAIMKNDKQTVWINGLYLIGLAIIGIIGGIVNTIYAARVALGVATDLRADEYAKIQSLAYADVEKFSPSNLVVRMTNDINQVQQIIMGFFQQVTRIPILFVGAVILAIMTLPELWWVIAVMMILVFGVSFFSFSHMGKYFGRMQQLIERVNTLARENLMGMRVVKSFVQGANQIKTFAESSDEMRDVSVKIGNLFALLMPAFFLVANLAMAGSIWLIGQDITSHPSNLAAITSFINYLMQILFAIINGGFMLTFASRALVSLKRIQEVMDTKPSMTFVSGPHRDLDGAVEFDDVTFTYPGDEKPTISDISFKVKSGEMIGIVGATGSGKTTLAQLIPRLFDPDTGIVKVGGHDVRAVTEADLRKTVGFVLQRSTLFSGTIAENLQQGNPNVNLDAMRWAARIAQSAEFIERLPRTYNAEVEERSSNFSGGQKQRLSITRGVIGQPKILILDDATSALDAHSEKLVQEALAHELGDTTTIIIAEKISSIIKADRILVLDEGRLVGSGTHHDLVQHNDVYREIYATQKALEEGV
>NC_021721.1|WP_003662794.1|720143_721925_+|ABC-transporter-ATP-binding-protein
MKDLKNAGKFYAHYLKPYWIEFLITTILVGISTWAIVVAPTYMGRAIEELATYVQQWMNPATRAQATFTTFNHTLAIFVLLYIIDATSILISSLLLSKISGYSTGTMRVGLFRKMQRMKVNYFDSHSDGDILSRFTSDLDNIFNAMNQALIEIFLSGAQFIGIIWMMFTQNATLAWITMASTPVAVGLSAFVMHQASVSVDRQQDDIGRLNGYINEQITGQKMLITNGLQQESVAGFQPYNAAVRKSNLRGQIWSGILNPLLMGLSLLNTAIVIFAGSWLALNGSLSQGAALALVVVFVNYAQQYYQPIVQLTSLFNMIQLAITGARRITEVREQPDEVDPPEGKTLDGLKHELLIDNVHFSYIPGKEILHGVTIKVDKGEMVALVGPTGSGKTTVMNLLNRFYDVDSGAITFDGVDVREFKLASLRQNVGIVLQDPQLFSGTIRDNIRFGDPDADQARVEAAAKQANIHDFIVSLPEGYDTFVSDEQSVFSAGQKQLMSIARTILTNPRLLILDEATSNVDTVTEAKIQAAMDNVIQGRTSFVIAHRLKTILNADKIVVLRDGNIIEEGSHEQLLAQNGFYAELYHNQMVFE
>NC_021721.1|WP_003573843.1|722086_723331_+|OFA-family-MFS-transporter
MSKRRYLVAIGGILLHLMIGSVYAWSVFTGPIAKQTGWALSSVTVAFSIAIFFLGMSAAFMGRLVERFGPRLTGTVAALLYGSGILLTGLAVQLESLPLLYIGYGVVGGLGLGAGYVTPVSTIIAWFPDKRGLATGMAIMGFGFAAMLTGPIAQNLIAGIGLVPTMYVLGTAYLLIMLTAAQVIRKPRPGEVPAADIAKSVSLTGTAMTANQAVKTRSFRYLWLMFFINITCGIGLVAVASPMAQQQTGMSAATAAMMVGVVGLFNGFGRLAWATLSDLIGRPLTYTLIFTVDVAMLAGILVFSSPLLFGIALCLIMSCYGAGFSVIPAYLGDVFGTKQLGAIHGYVLTAWAVAGVVGPTLLSLSDQYFHSYTYSLIFFVALELVAFILSIRIRRQFSVVARDEKVTDSLERQH
>NC_021721.1|WP_003587307.1|723617_724334_+|trehalose-operon-repressor
MRKYDVIYQDLKDKIEAEIYTTGSLLPSENTLQDMYQASRDTVRKALRLLKDDGFIQSQKGRGSIVINRQEYVFPVSGVVSYAELAKQLHLQTRTVVLANHFAALPAKSFKDVDPDVEVKQMRLLKRVRYLEKEPDIIDIDYLDPRVVPPIPESVARDSLYAYLEGQIGLEIAYATKEITVETATEEDRRYLNLPEGAMVVVVRSCSSLADTRKFQYTESRHRADRFKFHDFARRTRP

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Crispr_ID: NC_021721_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021721_3

795086-795201

Orphan

Consensus_repeat	Method
CTTTGGTCGTTTAGGTTCGAGGTCCTTATGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021721_3

>merge|NC_021721|3|795086-795201|CRISPRCasFinder
CTTTGGTCGTTTAGGTTCGAGGTCCTTATGCGGAGGTTTCTGGGCCAGTTTGCGCGTTTCGGAGTTCAGCAATATCAGGCAGGGCTTTGGTCGTTTTAGGTTCGAGGTCCTTATGC

>NC_021721|3|3|795086-795201|CRISPRCasFinder
CTTTGGTCGTTTAGGTTCGAGGTCCTTATGC	GGAGGTTTCTGGGCCAGTTTGCGCGTTTCGGAGTTCAGCAATATCAGGCAGGGC
TTTGGTCGTTTTAGGTTCGAGGTCCTTATGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021721.1\|WP_020751491.1\|799703_800228_+\|DUF308-domain-containing-protein	unknown	unknown	unknown
NC_021721.1\|WP_003563741.1\|788140_788569_-\|galactose-6-phosphate-isomerase-subunit-LacA	unknown	unknown	gnl\|CDD\|181505
NC_021721.1\|WP_003563758.1\|794826_794970_+\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003659923.1\|800460_801093_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227169
NC_021721.1\|WP_003563775.1\|797993_798779_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NC_021721.1\|WP_003563790.1\|801164_801986_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|238574
NC_021721.1\|WP_013245516.1\|796679_797783_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NC_021721.1\|WP_003563737.1\|786537_787539_-\|tagatose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|183502
NC_021721.1\|WP_003563777.1\|799446_799626_+\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_020751489.1\|791602_794728_+\|SMC-family-ATPase	unknown	unknown	gnl\|CDD\|223496
NC_021721.1\|WP_003563743.1\|788573_789350_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_021721.1\|WP_003563792.1\|802159_803221_-\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003573966.1\|795633_796110_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107228
NC_021721.1\|WP_003563733.1\|784782_785463_-\|DUF4867-family-protein	unknown	unknown	gnl\|CDD\|379783
NC_021721.1\|WP_003563745.1\|789794_790421_-\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|372595
NC_021721.1\|WP_003563776.1\|798781_799450_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|376808
NC_021721.1\|WP_003659920.1\|796103_796337_-\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003563746.1\|790481_791603_+\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
NC_021721.1\|WP_003659914.1\|785484_786423_-\|tagatose-6-phosphate-kinase	unknown	unknown	gnl\|CDD\|237405
NC_021721.1\|WP_003563739.1\|787577_788096_-\|galactose-6-phosphate-isomerase-subunit-LacB	unknown	unknown	gnl\|CDD\|181506

Protein	Function_ID	Function_description	E-value
NC_021721.1\|WP_003563741.1\|788140_788569_-\|galactose-6-phosphate-isomerase-subunit-LacA	gnl\|CDD\|181505	PRK08621, PRK08621, galactose-6-phosphate isomerase subunit LacA; Reviewed.	1.14806e-74
NC_021721.1\|WP_003659923.1\|800460_801093_+\|hypothetical-protein	gnl\|CDD\|227169	COG4832, COG4832, Uncharacterized conserved protein [Function unknown].	6.76065e-11
NC_021721.1\|WP_003563790.1\|801164_801986_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|238574	cd01169, HMPP_kinase, 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of the hydroxyl group of HMP to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate (HMP-P) and then the phophorylation of HMP-P to form 4-amino-5-hydroxymethyl-2-methyl-pyrimidine pyrophosphate (HMP-PP), which is the substrate for the thiamine synthase coupling reaction.	4.1808e-94
NC_021721.1\|WP_013245516.1\|796679_797783_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	1.3412e-123
NC_021721.1\|WP_003563737.1\|786537_787539_-\|tagatose-bisphosphate-aldolase	gnl\|CDD\|183502	PRK12399, PRK12399, tagatose 1,6-diphosphate aldolase; Reviewed.	0
NC_021721.1\|WP_020751489.1\|791602_794728_+\|SMC-family-ATPase	gnl\|CDD\|223496	COG0419, SbcC, ATPase involved in DNA repair [DNA replication, recombination, and repair].	2.47898e-77
NC_021721.1\|WP_003563743.1\|788573_789350_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.34504e-74
NC_021721.1\|WP_003573966.1\|795633_796110_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107228	cd06471, ACD_LpsHSP_like, Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Transcription of the genes encoding Lp HSP 18.5, 18.55 and 19.3 is regulated by a variety of stresses including heat, cold and ethanol. Early growing L. plantarum cells contain elevated levels of these mRNAs which rapidly fall of as the cells enter stationary phase. Also belonging to this group is Bifidobacterium breve (Bb) HSP20 and Oenococcus oenis (syn. Leuconostoc oenos) (Oo) HSP18. Transcription of the gene encoding BbHSP20 is strongly induced following heat or osmotic shock, and that of the gene encoding OoHSP18 following heat, ethanol or acid shock. OoHSP18 is peripherally associated with the cytoplasmic membrane.	8.90883e-46
NC_021721.1\|WP_003563733.1\|784782_785463_-\|DUF4867-family-protein	gnl\|CDD\|379783	pfam16161, DUF4867, Domain of unknown function (DUF4867). This family consists of uncharacterized proteins around 220 residues in length and is mainly found in various human gut Firmicutes and a few eubacteria species. It is also amply represented in human gut metagenomic datasets. Distant homology analysis and marginal HMM overlaps suggest this family is a distant homolog of Ureidoglycolate hydrolase pfam04115, but this prediction is not verified by experiment, therefore the function of this family is still unknown.	8.17986e-88
NC_021721.1\|WP_003563745.1\|789794_790421_-\|HAD-IA-family-hydrolase	gnl\|CDD\|372595	pfam13419, HAD_2, Haloacid dehalogenase-like hydrolase.	8.24385e-35
NC_021721.1\|WP_003563776.1\|798781_799450_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|376808	pfam02525, Flavodoxin_2, Flavodoxin-like fold. This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.	4.81778e-31
NC_021721.1\|WP_003563775.1\|797993_798779_+\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	1.99527e-22
NC_021721.1\|WP_003563746.1\|790481_791603_+\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	4.36447e-49
NC_021721.1\|WP_003659914.1\|785484_786423_-\|tagatose-6-phosphate-kinase	gnl\|CDD\|237405	PRK13508, PRK13508, tagatose-6-phosphate kinase; Provisional.	1.6225e-143
NC_021721.1\|WP_003563739.1\|787577_788096_-\|galactose-6-phosphate-isomerase-subunit-LacB	gnl\|CDD\|181506	PRK08622, PRK08622, galactose-6-phosphate isomerase subunit LacB; Reviewed.	6.20591e-104

>NC_021721.1|WP_003563758.1|794826_794970_+|hypothetical-protein
MASLSKEQKKALIAKVEKERQDHPEKKSKKSGFETIDEEAERLESEN
>NC_021721.1|WP_020751489.1|791602_794728_+|SMC-family-ATPase
MQLKQLHMQFFGPYADAVVDFDDFRTSPLFLISGPTGSGKTTIFDALIYALYGETSGERDGGQMRSNFAGNSDLTKVTLTFDHDGKHYLIERQPPQLQSKKRGDGLTEVKAKVLLAISSDEKQVAEYRKKNQVQEQLDAVLHLDASQFRQIVLLPQGDFRRFLDADSNAKEDLLRDLFGTQLIQRWQTAMLAQMKAKGAAIQDQERMLDVLMSQFDFETAPDEHATMADKLSLMRATVASQAKVVTARQATAAQSHQRYQEAQTALQQGQQLAQAFTEREQAATALAKLAEQKQTHQKQLKQIEQLTWVQQHENAAQRVQKAGQDLKAAIVQSEQTQAALTTTEQKFSLDKQALARLQAKSDQIEAQKKQLNSLQAVQQQLTAIAEQNKQVIKQAAIVNEAELALTHAQQQLTDAQTVKTQQQTSLDNLGLDELITTVNTQRNLLAALAPQAANYQEAQADVAQLSMAIKKTQVTLEQAETQVAATTSHLNKLQQTQIRQQIAHLAAKLEPDSPCPVCGSTSHPHPALVVDEPLVSEAALKQADQERQKAAARKTMVETQLANLETQLKTAKAKTAQARQAFTEHWQEQAKLIAGVADKTGILQQLTALKTLAATNEHQLTEAQTEHAALQVALKKSDKAITTGTTKVQQCEASLNTARIDAAEAESALKTMQKNLPAEATDLATVAAQATTLQTTITTYQAQLQEAQARVNALDRQLAGLQADEKHAAAQVTALTKEQAEAKATFTIAVTEYFGADGKQRFAELQLRVSQLPLLNEQVQTYEHTQLKQQTLLDAANKTIGTQAQPQLDQLEAEATAAETTATNDQTALIKISQAHDAAEKLAKQAATIFTVNQTALAAYADLQTLATVMNGNGPKKLSLERYVLQAYLQEILNVANSRLQVLSNNRYQFVLHTSLGTQKIHSGLEIDVYDDQVGEKRAVQTLSGGESFIAALSLALALGEVIQQESGGINIDALFVDEGFGSLDANSLDVAMNALESLEGESRLIGIISHVTELRDNIPDQLQVEPAGTGRSRLKILHSA
>NC_021721.1|WP_003563746.1|790481_791603_+|exonuclease-SbcCD-subunit-D
MRFLHTADWHIGKKLNDFDLLEDQQAVFEQLVETAKQHKVDAIVIAGDLYDRALPSEAAVSVLDNMLIKLNRDHGYPLLVISGNHDSAVRLRTGRAWYAATKMFVNTQVAEAFTPIELDGVQFFLLPYFEPFAVRDYFQDKTITNVAQAIRPIVAKMKTLFKPDMRHILVSHFFAAGSDHSASETKVNVGGLDAVPLDDLAAFDYVALGHLHNHHALHGEPKIQYSGALLKYAVSEAHQEKGVYIVDTETMDREFVPLKPKHDLIELKASYADLTAPAYYQQQDRDAYIGIDLTDTQVIPNVMAQLRQIYPRIISLRRENGVNAIKPLQERQRDLDPMSLLQTFFKDMTQDDLSAAQIKWAKAGLTTAKKEQA
>NC_021721.1|WP_003563745.1|789794_790421_-|HAD-IA-family-hydrolase
MNTFIFDIDGTLLDNVEAYLYGLQKTLRRHGREVPIHELTWTNGRAGVDSLAELGFSAAEIPEVHEQWREDSKEFLTDIAWFPGMQHALNQLKQTYKLGLVTSKDKTQFIEEDKKFHFSPYFDAIVVAGEAKRNKPFGDPITLARERLGSEPASTIYIGDTPTDAQAAADAKVAFALAGWTTPPSNEVMPRVAVLQQASDLLTLPTLA
>NC_021721.1|WP_003563743.1|788573_789350_-|DeoR/GlpR-transcriptional-regulator
MLKDERLLTIRNLVDRKGIVTVNEIGESLGVSTMTVRRDLEELADQKELVRIHGGAQSTNFKPLTELSRNEKRSIHVNEKRKIAATIAALIIPGDTIYIGPGTTNEMIAQYLKKPDVRIITNSLPVFQSFQDRADFFSLQLIGGRLRARSGAFIGSLANEMLAHLTTTKAFISVNGIADNHISNASPEEGQTQRIALDNAGMKLVVADHFKLNRQDFYSFYDLDQTDGLITDPGISRDDLQHYNTFTHVITDKTNKGE
>NC_021721.1|WP_003563741.1|788140_788569_-|galactose-6-phosphate-isomerase-subunit-LacA
MDVIIGADKDGFAMKEQVKKYLEDHQYRVKDMTPEPAEDFVDSSLAVTKELLGGDAHKAIMFDRYGVGSAMASNKVKGMVTAVVEEENTAHMTAEHNGAKAIAIGTGITGYDRALVIIQRYLDTEYAGGRHQIRLDMLEKMI
>NC_021721.1|WP_003563739.1|787577_788096_-|galactose-6-phosphate-isomerase-subunit-LacB
MIIAIGNDHIVTMQKIEISNMLKDMGYTVIDEGTYDTHRTHYPIYGKKVAEDVADGRADLGIVMCGTGIGISTAADKNDGIRAAMCDDVTSAVYAREQLNANVLGIGGATVGIHMIQDIVKAYLDATYKETPENKKIIDKIDNIAKPNPEQKDNPHFFDTELEKWAEGVYHD
>NC_021721.1|WP_003563737.1|786537_787539_-|tagatose-bisphosphate-aldolase
MTVTLTAGQYKHLQQLSDDNNVISALAIDQRGSLKKMLAAAANKPADETTIVDFKKAVSEELTKYASSILLDPEYGLPAAKVRAPQAGLLLSYEKTGYDATEPGRFPDLIDDQSALRIKNEGGDAVKFLLYIDPDEPDAINDRKYAFVERVGAEAKANDLPLFLELVSYDGTLNETGTAAWAKVKPDKVIKITKEFSKPQYNVSVLKVEVPVDQKFVEGFTDQGVTPVYTKEEAAKYYKAQSDATDLPFIFLSAGVSNELFLEELKFAKQAGSTFNGVLCGRATWKPGVKPFAAEGEAAGKAWLETEGKANIDRLNKVLAETATPWTDKVEHA
>NC_021721.1|WP_003659914.1|785484_786423_-|tagatose-6-phosphate-kinase
MILTVTLNPSIDVSYPLEHLKIDTVNRVKTVRKTAGGKGLNVSRVIHMLNHEITATGFIGGYFGKWLENQLDRDGIDHDFFPIDAETRSSIAMLHDGGEQTEILEAGPTIAAEDAEKFLSHFDSLLDKSDLITISGSMPQGLPADYYTQMIAHAGQKNVKVLLDTSGATLKSALEAPVKPLLIKPNEEELGGLLNREVDKTDYAALKQDLIDPIFDGVDWIVVSLGAAGAFVKHLDKFYHAAIPKIKVVNPVGSGDSTLAGLAMGIHDGKSDEDIMKTAMTTGMLNTMEAETGFVNPAKFDEYFAKVTIESY
>NC_021721.1|WP_003563733.1|784782_785463_-|DUF4867-family-protein
MSTIDQLRTLNPDKTIHSLDEAAFADYGVTYAQYDVSELKAFMDQHVTIPAPSEANLYIPSNPDMERIPVVQQIGRDVYAGLPIEAGECAGHADALTAVEFHQGSEVNVFFTDVVMVIGKRGQMHDGQFNAEKDAKLFFVPAGTVVEFFSDTLHYSPCEAHASGFKFIVMLVRGSNQPLPADYHTDNKLIVKQNKFQVVHASRTDKIKQGIQVGVTGELVQVKHLN
>NC_021721.1|WP_003573966.1|795633_796110_+|Hsp20/alpha-crystallin-family-protein
MANEVLNRRNNELMNNVNDPFFDNLARRFFGPVSDWMDWATPAITSTAVNGLLTDVKETKDAYEVHVDVPGIDKNNIKMNYHDGVLSINVHKDDITDHADKNGNVMMSERNYGTMSRSYQLPNVDASNIKAAYQDGVLNITMPKLTESKESGHNIEIQ
>NC_021721.1|WP_003659920.1|796103_796337_-|hypothetical-protein
MFRFLIAPFRALQKNHPNDHTYRWDDFNDSMITATAAILIDFCLLTHGFCPLTAEVPLLFMLAMQSVNLGSADDEHY
>NC_021721.1|WP_013245516.1|796679_797783_+|A/G-specific-adenine-glycosylase
MTNKLINWPPEKVAAFQKALLNWYDQHARQLPWREDHDPYHVMVSELMLQQTQVQTVIPYYERFMNQFPTVGALAKAPEAEVLKAWEGLGYYSRARRLQQAAKQIVADYGGVWPQTSETLQTLSGIGPYTAGAIASISFGEPVPAIDGNAFRVFARLFKVDADIARPQTRQIFFDLIQPLMPKDRPGDFNQAVMDLGSSYMSANHPDPAHSPVRDFDASYRDGVVSAYPVKTKKPRPVLHRYFALVIRSEKGYLLEQRPSTGLLADLWMFPLVDMADLESTMMSAQLDEVSTLFAASSGMQLTFADLGAKTVKHTFTHQQWQLTLIGVETAASDLSFLPARWVKADHFSELALPTVQKKLNAALGMN
>NC_021721.1|WP_003563775.1|797993_798779_+|alpha/beta-hydrolase
MTVKVTRDIAYGDAALQKLDFYEPEKSNGAAILDIHGGGWFRGEKNKEGEMAERFAALGYTVAVPNYRLAPEAFFPAARDDVLAAFSWLREHTKGLQLGVFGSSAGGSLSVDVGLAEGVPTVSWSGIFDIRQWFADHPAVVAQPDTKTDFVKTASAKIDQGGRNDPFYKWFILNYVDSDETKFPEVEPFDRLTAQAGPLYLANSQEEIIPISGIYQLAHAAEKLGLPVTLQSIPGGQHAEGYLDEAWQGTVAFFAQYLLKG
>NC_021721.1|WP_003563776.1|798781_799450_+|NAD(P)H-dependent-oxidoreductase
METLVVVSHPEIEKSDTQQFLKASAASLSQVVWHHLDSRLPFDVTAEQQAITSADRLIFQFPLYWYMAPASLHQWLTDVWLKQFVYDARGGLLHGKSLGFVVTFSQPATAYQLGGSVGFSISQFLTPYAALAAKTGLTLLPPLTIAQFANQTDLEHQQLLVRYQQYLTLDHPDRPDEQAQWFIDRLSGNADTQLLADQLAAQTDDIDRLRLTLHELKAGESE
>NC_021721.1|WP_003563777.1|799446_799626_+|hypothetical-protein
MTTDEQWLVNAAAVQEKQATSYENAAFFRALQAFVTQQAKRRESLEGEIDGRSWNHEQW
>NC_021721.1|WP_020751491.1|799703_800228_+|DUF308-domain-containing-protein
MQTMFDRLQRWSWLRGLLMILIGAWILIAPRQVYRSFLWIVAAVLIIAAIPKLIDGFSARKASGTYGTSLFTGGFYLLLALMVPVIVRPLMSLGPLLLGIVLMIYGVNKILSARNRQQFVNVSVWPTVIYGVVLLIMGFIMALNTFRTVMMVFSFFGGLLVVMGILQLFTRPRA
>NC_021721.1|WP_003659923.1|800460_801093_+|hypothetical-protein
MHKFDWREVERDEYSRSEEPSFVKLTTRSYITAMGVAPDRVTDQAFTSLAAAVTQIAERISEGPDAGIDIPNFKAYHPYPLQAVWSGGDKISKRHIFRLWLKQPLFIHEDQFEAALTQLHFEPAIAQQLHLEQLAEGFEIQSFNSTPLTDEAPAIAHIQTVINRDHLVPKFDDRHREVYLEGYQGEVPVLYRVPLDENFGEVGDEQVAYN
>NC_021721.1|WP_003563790.1|801164_801986_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MANEFPQVMTIGGTDSDGSAGVQADLHSFFMRGVYGATILTAAVAGNSYGIQDSMVMPLPFIDAQFKSLAADLHIRAAKTGMLADRALVQNIIKNWQQYDFGALVVDPVIITKHGAMLLEQDAYDAVKNELIPLATVVTPNHYEAEHLTGMKLDTDAQTEAAAHQLQDSGAKNIVLKGAHDDPTQPTVRDFVLLESGKSFWLSEPYHATDRVNGTGDTLSAVITAEIGKGNSVEEAIRIAKRFTNQAIGHPIAVGHQYGPINHWANKIVYPQF
>NC_021721.1|WP_003563792.1|802159_803221_-|hypothetical-protein
MLNLNDAHLAALITKPLTVAQARQQIGTAYQQEADRLANSPLWESNDEALTALLASYTNLLGNKLYQALQNLTSIPTPFLQTLWLQDTTADAHHSEIAVIQTTQDDNNTLLTIVDPLSDDAKLKAVNLPTLLQITAADSNAMTYDAETVKALSALAKALNQGGYRFTTVDETVLQPVNGLSFKTRFDNLKPLVAKKAVIKAGDFSIGTSLDQDAKVLGYQVLDEDGHDWQDLGSEEVKNDRFEWASTTVPQELVNHRLKLIIRVSAGSNSPALDELFVIASNNAILMRQGAKAGVYELPLPNQKIFTVMINPANNMVYLKYPDPETQIIELNHQYPFIGEWLKAVLPQKRAFN

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Crispr_ID: NC_021721_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021721_4

1927356-1927476

Orphan

Consensus_repeat	Method
CGGTTTCTAAACGCGTTCGCCACCCCAGAAACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021721_4

>merge|NC_021721|4|1927356-1927476|CRISPRCasFinder
CGGTTTCTAAACGCGTTCGCCACCCCAGAAACCAACGTGTAAGGGCCTTGGTCGCAATGACCATTGTGCGGCCATCCCACTTACACTACGGTTTCTAAACGCGTTCGCCACCCCAGAAACC

>NC_021721|4|4|1927356-1927476|CRISPRCasFinder
CGGTTTCTAAACGCGTTCGCCACCCCAGAAACC	AACGTGTAAGGGCCTTGGTCGCAATGACCATTGTGCGGCCATCCCACTTACACTA
CGGTTTCTAAACGCGTTCGCCACCCCAGAAACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021721.1\|WP_003566067.1\|1926529_1927135_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|227029
NC_021721.1\|WP_003566048.1\|1916433_1918188_-\|pyruvate-oxidase	unknown	unknown	gnl\|CDD\|213733
NC_021721.1\|WP_003566068.1\|1927861_1928326_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_021721.1\|WP_003566065.1\|1925311_1926451_-\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349944
NC_021721.1\|WP_013245838.1\|1924433_1925252_+\|aldose-1-epimerase	unknown	unknown	gnl\|CDD\|185696
NC_021721.1\|WP_003575994.1\|1919661_1920942_-\|hydroxymethylglutaryl-CoA-reductase,-degradative	unknown	unknown	gnl\|CDD\|153082
NC_021721.1\|WP_003566081.1\|1935576_1936734_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_021721.1\|WP_003566058.1\|1922779_1923610_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NC_021721.1\|WP_003566078.1\|1932034_1932472_-\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003566083.1\|1936953_1937781_-\|ammonia-dependent-NAD(+)-synthetase	unknown	unknown	gnl\|CDD\|234831
NC_021721.1\|WP_003566070.1\|1928318_1928771_-\|SprT-family-protein	unknown	unknown	gnl\|CDD\|235290
NC_021721.1\|WP_003566079.1\|1932608_1935269_-\|cation-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319781
NC_021721.1\|WP_003566061.1\|1923757_1924321_-\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|377369
NC_021721.1\|WP_003566085.1\|1937783_1938977_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_021721.1\|WP_013245836.1\|1918511_1919678_-\|hydroxymethylglutaryl-CoA-synthase	unknown	unknown	gnl\|CDD\|213655
NC_021721.1\|WP_013245837.1\|1920953_1922135_-\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|180261
NC_021721.1\|WP_020751590.1\|1930553_1931549_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380548
NC_021721.1\|WP_003566056.1\|1922479_1922779_+\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003566072.1\|1928912_1929665_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224026
NC_021721.1\|WP_003566074.1\|1929657_1930557_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226605

Protein	Function_ID	Function_description	E-value
NC_021721.1\|WP_003566067.1\|1926529_1927135_-\|ECF-transporter-S-component	gnl\|CDD\|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	7.14562e-17
NC_021721.1\|WP_003566048.1\|1916433_1918188_-\|pyruvate-oxidase	gnl\|CDD\|213733	TIGR02720, Pyruvate_oxidase, pyruvate oxidase. Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an enzyme with FAD and TPP as cofactors that catalyzes the reaction pyruvate + phosphate + O2 + H2O = acetyl phosphate + CO2 + H2O2. It should not be confused with pyruvate dehydrogenase [cytochrome] (EC 1.2.2.2) as in E. coli PoxB, although the E. coli enzyme is closely homologous and has pyruvate oxidase as an alternate name. [Energy metabolism, Aerobic].	0
NC_021721.1\|WP_020751590.1\|1930553_1931549_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380548	cd06325, PBP1_ABC_unchar_transporter, type 1 periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally.	4.28743e-103
NC_021721.1\|WP_003566065.1\|1925311_1926451_-\|M20-family-metallopeptidase	gnl\|CDD\|349944	cd08659, M20_ArgE_DapE-like, Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like. Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE) like family of enzymes catalyze analogous reactions and share a common activator, the metal ion (usually Co2+ or Zn2+). ArgE catalyzes a broad range of substrates, including N-acetylornithine, alpha-N-acetylmethionine and alpha-N-formylmethionine, while DapE catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelate (L,L-SDAP) to L,L-diaminopimelate and succinate. Proteins in this family are mostly bacterial and have been inferred by homology as being related to both ArgE and DapE. This family also includes N-acetyl-L-citrulline deacetylase (ACDase; acetylcitrulline deacetylase), a unique, novel enzyme found in Xanthomonas campestris, a plant pathogen, in which N-acetyl-L-ornithine is the substrate for transcarbamoylation reaction, and the product is N-acetyl-L-citrulline. Thus, in the arginine biosynthesis pathway, ACDase subsequently catalyzes the hydrolysis of N-acetyl-L-citrulline to acetate and L-citrulline.	1.94339e-127
NC_021721.1\|WP_013245838.1\|1924433_1925252_+\|aldose-1-epimerase	gnl\|CDD\|185696	cd09019, galactose_mutarotase_like, galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.	4.6714e-24
NC_021721.1\|WP_003575994.1\|1919661_1920942_-\|hydroxymethylglutaryl-CoA-reductase,-degradative	gnl\|CDD\|153082	cd00644, HMG-CoA_reductase_classII, Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR), class II, prokaryotic enzyme is a homodimer. Class II enzymes are found primarily in prokaryotes and Archaeoglobus fulgidus and are soluble as they lack the membrane region. Enzymes catalyze the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. Bacteria, such as Pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. Human and bacterial HMGR differ in their active site architecture.	0
NC_021721.1\|WP_003566081.1\|1935576_1936734_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	3.83637e-45
NC_021721.1\|WP_003566058.1\|1922779_1923610_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	2.188e-08
NC_021721.1\|WP_003566083.1\|1936953_1937781_-\|ammonia-dependent-NAD(+)-synthetase	gnl\|CDD\|234831	PRK00768, nadE, ammonia-dependent NAD(+) synthetase.	0
NC_021721.1\|WP_003566070.1\|1928318_1928771_-\|SprT-family-protein	gnl\|CDD\|235290	PRK04351, PRK04351, SprT family protein.	5.42742e-83
NC_021721.1\|WP_003566079.1\|1932608_1935269_-\|cation-translocating-P-type-ATPase	gnl\|CDD\|319781	cd02089, P-type_ATPase_Ca_prok, prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1. Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_021721.1\|WP_003566061.1\|1923757_1924321_-\|restriction-endonuclease	gnl\|CDD\|377369	pfam04471, Mrr_cat, Restriction endonuclease. Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA.	1.30041e-36
NC_021721.1\|WP_003566085.1\|1937783_1938977_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	8.24724e-43
NC_021721.1\|WP_013245836.1\|1918511_1919678_-\|hydroxymethylglutaryl-CoA-synthase	gnl\|CDD\|213655	TIGR01835, 3-hydroxy-3-methylglutaryl_CoA_synthase, 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade. This clade of hydroxymethylglutaryl-CoA (HMG-CoA) synthases is found in a limited spectrum of mostly gram-positive bacteria which make isopentenyl pyrophosphate (IPP) via the mevalonate pathway. This pathway is found primarily in eukaryotes and archaea, but the bacterial homologs are distinct, having aparrently diverged after being laterally transferred from an early eukaryote. HMG-CoA synthase is the first step in the pathway and joins acetyl-CoA with acetoacetyl-CoA with the release of one molecule of CoA. The Borellia sequence may have resulted from a separate lateral transfer event.	1.85604e-155
NC_021721.1\|WP_013245837.1\|1920953_1922135_-\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	1.64753e-180
NC_021721.1\|WP_003566068.1\|1927861_1928326_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.67331e-15
NC_021721.1\|WP_003566072.1\|1928912_1929665_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224026	COG1101, PhnK, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	7.00008e-96
NC_021721.1\|WP_003566074.1\|1929657_1930557_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|226605	COG4120, COG4120, ABC-type uncharacterized transport system, permease component [General function prediction only].	4.77747e-94

>NC_021721.1|WP_003566067.1|1926529_1927135_-|ECF-transporter-S-component
MTQRGKAYNIAIIGILGALIILQAYIPMVGYVQIFPAWPAISTIHLTVIIGGIVLGYGGGASLGLLWGLTSLIRAYTSATDPVTLLLFRNPIIAIVPRVMVGLVAAFIFHQLFKKKQTPLAQTVKMVFAGVVGALTNTLLVIGFTWLMFASKAAQIVPGADATNLGWLLMTALAINAVAEALLGGIVTPILGHALLRFRRK
>NC_021721.1|WP_003566065.1|1925311_1926451_-|M20-family-metallopeptidase
MTEEEQVVDLLSAMVKIPSVAAKEGQVADLIETFLAPELKAGLIKRERISYAPGRDNLVLTIGNPNAQRWLGVDGHMDVVDPGNVNKWQFPPFSAHVEDGKLYGRGATDMKSGLAAAVVAFKQAAHEKLDHGIQLMATVGEEVDNDGARQLSAAGYGDRLTGLLVAEPGNSNVDAAERGIIDYTLTAHGKAAHSSRPDLGANAIHGLFAFANAALTATAPLQAKEDPILGHATHNIDIIHGGNQINSIPESAYLRGNIRTTMIADNDAFIAALKQAAKTTVPKGVRLSLSIDSVLGAAAASPDNDLIQLVQTARQRAGLNRGQVAYRTGITDAALFYHDGLDLAIYGPGNETSHETDEYVTLKDVFDSVKVFKDVFMNY
>NC_021721.1|WP_013245838.1|1924433_1925252_+|aldose-1-epimerase
MQLSAKIFAKVGSERITQYSLVNDHQMTLRFLTFGARVQQVRLPNAAGDDPNLLLGFVTLEDYLHQPGYLGAFTGPLQAADAELAPGSWQNWNWAVKTSQETDLAITFTLTLPENADGQPGQRELSITHRLTNDNLWQIDMQVATTADLKIHPRLNLPWMLTADPAQTMLSAKLTADEHVTPVPKTARCETAQRYSLAAADWQLAYLSDASFTRIDSYAGINSENNFNGILGQPNVAVGFSPEMNQDALPWVLPAGATWRHHAEFHLSSNAN
>NC_021721.1|WP_003566061.1|1923757_1924321_-|restriction-endonuclease
MRTLLKKAYQLLWGLFILALAYSFWARSFLPRQLRQYGDPASFGIISLFVVINAIMLYHHHFRFRDLKMETVDIMEGEKFESFCAYLLKRNGFNHIQLTQASGDQGIDIIARKKGKTIGFQCKRYTGFVGNKAVQEVWAGHHFYQLDEAAVITNSEFSDSAIALADDLGVMLIDRKKLRRLMRRLPS
>NC_021721.1|WP_003566058.1|1922779_1923610_-|sugar-phosphate-isomerase/epimerase
MLLGLKASTDQRQIRDRLQYHPDVFEFHLTENDFTEAGWSHFVQMAALVQSLVPTVVFHHPMRFRGQRNELAMNPTKYPTRYDFLMTSSVKLMNFAKKANATALIHGGYRVDTPGDYAGWTDVGKAQDVALARMIAFAQEAPGHVVFENSMSPIFRYGDPTFEDRLLRWHLPLAYDTSHTFIVLHGDNDRLMASLAHLRPLIRHYHLVDSMGQTHDSLPLGRGRIDWARVLPLLNQNASRIYEIGLKDQFDCREMIESHHYLESVAKRLAATKHPA
>NC_021721.1|WP_003566056.1|1922479_1922779_+|hypothetical-protein
MRVTDLLALLADQNKNASVLLDTKPTPSRFDDFKLTTVNDQPQLVFQPNPERKAALRVWELQLLLNQPDLQQRFVYLADVDEPRALFGFVKRQIGLLLN
>NC_021721.1|WP_013245837.1|1920953_1922135_-|acetyl-CoA-C-acyltransferase
MEEVVILSAKRTPIGKLGGDLAGASAVDLGVAAAQAAIKAARIDPALLNQAIFGNVMQAGSGQNVARQIGLKSGMATSSTAMTVNEVCGSGLKAVRLGQAAIQLGEADAVLVGGTESMSQVPYYAEAVRSGHKFGDTTLVDGLSRDGLNDAFSQQPMGITAENVATQFNVSRQEQDEFALRSHLRAAAAAAEGRFKSQIAPVTIAARHGDVIVDRDSAIRPDTSLAKLAQLPPVFEVGGTVTAGNASGINDGAAALILMAKSKAEQLGLHYLATITGFSEVGIDPAIMGYAPKLAIDKILQATGGSIAAIDQIELNEAFASQSVAVARDLGLKDEQFNINGGALALGHPLGASGARILISLLYDLGERNQRQGIAALCVGGGIGIAMQIAMHV
>NC_021721.1|WP_003575994.1|1919661_1920942_-|hydroxymethylglutaryl-CoA-reductase,-degradative
MKFYELSPEKRRDQLVQEGWLTTQDAALLAGTHSLPEVTGARLIENAIGEFPLPLGVARNLLVNGQLHQVPIADEEPSVIAAASNGARLATANGGVRTHVAAHRVVAEVVLTNLTDLVQARQTILAHQTDIQKVIAVAHPSMIQRGGGLDQLTVESLGAQFLKIRLTLDPQQAMGANYANTVAEAVAAAVTSWVDGDVLVSILTNAPTELVTAEVSLEPVSLATKAVSGDVIAKKIVQLSDLAFVDAERAVTHNKGILNGIIGAVLATGNDTRAVAASIGAFACASGRYQPLSRWYMDQGHLVGHLQLPLPMGAVGGAIGALPMAQVVRRLGGYQNLAIMQQVIAALGLVQNLAAMRALAGPGIQAGHMKLQANALAIAAGATETELPMLVNALRQGSMDLKHAQQYLTTIRLNKKVGQSKDENRD
>NC_021721.1|WP_013245836.1|1918511_1919678_-|hydroxymethylglutaryl-CoA-synthase
MKIGIDAIAMDTPDFYVDLVKLAQVRGDDPDKYTIGIGQDEQAVPPSSQDIVTMGANAATKLLTPAIRASLGMVLVGTESGVDASKSAALFIHDLLALPEWVRAVELKEACYGGTAALMMARDYIAAHPDKTVLVIAADIARYGLATAGEVTQGAGAVAMLIKAEPHIMTIEDDSIYRSESIDDFWRPVYQDTAIAQGKYSTEQYLAFFQAIWSRYQTQRHHTASDFAAMTFHLPYTKMGKKALKLVLPDTDEATGERLQRRFEASTRYCRRVGNIYTGSLYLGLLSLLDNDTSLKAGDRIGLFSYGSGAVAEFFSGILQPDFAAQLHAANHAKMLADRQELTVPEYEAVFSDKVPYDPEDYRSDPTYYHGQFVLTGVIGQERQYQQR
>NC_021721.1|WP_003566048.1|1916433_1918188_-|pyruvate-oxidase
MTEKINAADAMIKVLEDWGIHNIYGLPGGSFDSTMNALYNRRHTINYVQVRHEEVGALAAAGEAKVTGRIGATFGSAGPGAVHLLNGLYDAQYDNVPVLALVGQVPTAAMNTNYFQEMNENPMFADVSVYNRTAMTAEQLPHVVDEAIRQAYKHNGVAVVTIPKDLGWTQIDDNYVSSANLYQKPLLPDPDPDQVAAAWDILKDAKKPILYVGNGARGARDEIIAFSEKTHIPIITTALAKGIVPDDYKANMGSAGRVASKPGVEVARGADTVLFLGSDFPFQPYFIAPNAKYIQVDIDGSKFGRRHTVDLAVLADAKKFIKALSEKADQLPESAWYRAALANKENWREWMTSFEDDGSTPLRVEPIFKLINEMAEKDAIFQVDVGNVTINGMRYLKTNDDQVFTTSGWYATMGYALPAAIGAQAEFPDRQVWSISGDGGFAMVMQDILTQVKYHMPIINVVLTNESLGFIEAEQDDTQQPHSGVDLIDADYGKAAEALGAQGFEVHNLDELKAAFAKAKDRKGPVVIDVKISDLRPIPVEQLVLDKQTQDPAAVDAFVKKYHAESLIPFRQLLEDAEKPVTNA
>NC_021721.1|WP_003566068.1|1927861_1928326_+|GNAT-family-N-acetyltransferase
MLREAQFIDLGAIVHLYQQLTAEMATMAPETYRPLTSDNRQYFADYLQNDLARLFVTETAGTLSGFALVVLARTGDNAEFVPQHFAQLIDLYVIPAQRHQGLAKQLMDAVTAFAKSHDATFIQLNVLNANQTAQQVYAKAGFEPVSLIFQKPLN
>NC_021721.1|WP_003566070.1|1928318_1928771_-|SprT-family-protein
MTDQELQARVEAISLKAFHQPFRHHAVFNNRLKTTGGRFHPADMNLDFNPKLFAVYPASVTDGIIKHELVHYHLYDHHRGYQHRDHDFKQLLTAVGGSRFAPPLPVNGHQYVYVCTHCGRQFVRRRHIDVRRYACGVCRGKLRLQKTLAS
>NC_021721.1|WP_003566072.1|1928912_1929665_-|ATP-binding-cassette-domain-containing-protein
MAELTLTNVTVNIPVGTEVKTLLQDVNLTVAKGEFLTVLGNNGAGKSTLFNAITGDMPVSGGTITLADQTLNGKRPEQRARHIARVFQDPKMGTAPRMTVAENLLLASHRGQRLTLRSRGMTASKAALKTLAAKTGNGLADALDKPTEQLSGGQRQALSLLMATMRKPDLLLLDEHTAALDPHTSQAIMQLTNEIVSDQQLTCLMITHQVEDALRYGNRLIVLDAGKIVADFDQAKKAAMSRDDVLAFFS
>NC_021721.1|WP_003566074.1|1929657_1930557_-|branched-chain-amino-acid-ABC-transporter-permease
MSIGVSAIGQGLLYGLIGLGLFLTFRVLDFPDMTVEGTFPFGAALAVSAITHGISPIVATLLATGAGMLAGLATGLLTTKGKIPVLLAGILVMTGLFSINLRIMGRANLSLLHQANLFQTAFLKDLPPYFNSVVIGVIVAVVVVGLLMLFLNTQLGQAFIAAGDNPSMARSLGIDPDHQMVLGLMVGNGLVGLAGGLLAQNNGYADVNMGIGIIVIGLAAIIIGEVVFGELTLSQRLVAVILGSILYRFVLLVVLALGFNADDLKLISAVVLAIAIMVPQIDHRLRLRRVLQKGVQAHG
>NC_021721.1|WP_020751590.1|1930553_1931549_-|ABC-transporter-substrate-binding-protein
MKRMLGLIFIMAAFLGIAYFQTGTTTPQTQATPTVGILQLTTHPALDAIHKGIIDGLKEKGYVAGKNVKIDFQNAENDQSNLKSMSERFTEEHAAATVGIATPSAQELANVNQKTPIILGAITDPVAAKLVKNVKRPGGNITGVSDQAPIAAQLKLIRQIMPNAKTLGVIATSSDDSAQTQAKMVEKLGPKQGFTVKRYAISSTNDLNQVATQMVSQVDAIFVPTDNTVASAMQTLVAVANTRKVPIFPTVDTMVEQGGLATIGLDQHHLGVLTGRMLADILSGKTKPATTPIHFETTGKLILNEKQAKLLGIDLPSSLIKTAEAKGTVIK
>NC_021721.1|WP_003566078.1|1932034_1932472_-|hypothetical-protein
MNKQQMKLANYGTTINAVVEATQDNQEKMAPLFEPLRKAIDENKLADYDLEAYQQTQTVFSEGTSNYEALLVKLQQVAAPARLLGPHHTLVRDFAAFTEACKAMTASLHADRQVDVAAFNAAEKAQDEAIQKFTKQIQKISVMLS
>NC_021721.1|WP_003566079.1|1932608_1935269_-|cation-translocating-P-type-ATPase
MANKPPYALSSEAVLKQEQTSLTGLTKEAAQTRLNENGPNELAQAEKKGMLARFLDQFKDFMIIVLLVAALIAGFLLSEWADAGIILAVVLLNAVFGVFQESKAEEAIDALKEMSTPNAHVRRGDQVLTIPSSQLVLGDIVLLEAGDVVPADLRLVESANLKIEESALTGESVPVDKTTAPLDADDVGIGDRTNMAFMNSNITYGRGVGVVIATGMQTEVGRIAGMINSAEETNTPLQENLKSLGKTLTVMILVIAVIVFAVGIWRQAASLPEMFLTAVSLAVAAIPEGLPAIVTIILALGTQKMAKRHALVRKLPAVETLGSTDIIASDKTGTLTQNKMTVEKVYYDGQLNDASAGIHGGNPLMTIMNFANDTQVQDDGKLLGDPTETALVAYGKTQNYDVAKALTGEPRIAEVPFDSERKLMTTVHRRADGKLLVATKGAPDELLKRVTDLATGENTAPLSDSERDAILKANKDMATQALRVLGMAYKVIDTLPEKVDSDTVENHMIFAGLVGMIDPERPEAEAAVAEAKAAGIRPMMITGDHRDTAEAIAVRLGIIDQGDDDAVITGAELDQQSDDEFAKNVAKYSVYARVAPEHKVRIVNAWQKKGKVVAMTGDGVNDAPALKAADIGIGMGITGTEVSKGASDMVLADDNFATIVVAVEEGRKVFSNIQKAIQYLLSANLGEVLTLFMMTMLGWDLLAPVHILWINLVTDTFPAIALGVEPTEPGIMKQKPRGRKSNFFSGGVGPAVIWQGILEGLLTLGVYWIAITYPVHSGSAAIHADALTMAYATLGLIQLFHAFNVKSIHQSLFTVGAFRNKAFNWAILASFVLLAVTILVPGFNGLFHVTSLDWHQWITVLGAGVAMIVIVEIVKVFERARRKQRA
>NC_021721.1|WP_003566081.1|1935576_1936734_-|serine-hydrolase
MSGKHRYIWLGVMLILCAVSIGAGTYLWQQNSRSAVNTKAKSAKTVTKVVRQDRGKSKEEILAMTLDRAATTTEGQPLEQELTNDKFIGSALIIKHGKVVFNNGVGDADTTTHRRNGPTTLFQIGSIQKAVTAVALAQLAASGKLSLDDPVGKYLTGIKTGDQVTLRMMVAMRSGFSLRRYQPTVMDDANIIQWSIANLTYLPQDNYAYQAVNYVLLAGVIEKVAGRSYEQQVKNNIFDRLNLKHTGFLPAMLTDPERAITYTGPAANPYQTAIGEPAVWYNRELGTGNVYTSTGDLYRLLRGIDTGKVLSLSTLKTLRNRNDGVYNAGIYNHADFYSTNGVVAGQMASTAISHDGQNAVILLSNYNSHALNLHDLAVHLFSELG
>NC_021721.1|WP_003566083.1|1936953_1937781_-|ammonia-dependent-NAD(+)-synthetase
MRPLQAEIIKALGVQATIDPETEVRRSVDFLKAYLKKNTFLKTYVLGISGGQDSSLAGALTEKAMQEMRAETGDDAYQFIAVRLPYGEQADEADAMAAIDFMHADVVKRVNIKPSVDAMVAAVEADGSKISDFNKGNIKARMRMIAQYAIAGNNAGAVIGTDHAAEAVTGFYTKFGDGGADLTPLYRLDKRQGAALLKVLGAPAHLYEKAPTADLEDNRPALPDEVALGVKYKDIDDYLEGKDVSDQAAETIEKWYQKTAHKRHLPITVFDNFWK
>NC_021721.1|WP_003566085.1|1937783_1938977_-|serine-hydrolase
MRASKRRSQHRWLILSLLVGLVVGIAAYASYDHFYLKPQIEAKEERTRRKYEIELNRHRAVEQRLQNETRTATSATDKLMQPVNQAEAKPFMKILEANHFSGTALMIRRGKIILNTGLGYADAESGRLNGPETLYQIGSIQKGLTAVLLMRLVEQGKVHLSDPISKYLTGIRTGKQVTLRMMLNMRSGLSLTRAQSASLSDAGIVRWSIANLNYGTVRYDYQPVNYVLLAGVIEKVTGRLYADLIQQEIFKKLKLTHSGFMPELFHESNQAFGYSGPINNPYAKRYTEPSVNYNRELGTGNIYTSAGDLYQIIKAVNQGKIISTASLKALRNLDNGQYTAGVYNFGGYTLTHGVVASQSAGTMIDTSGQNAVVLLANTDKITQGLIKNLYLNMIKGV

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Crispr_ID: NC_021721_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021721_5

1948704-1948810

Orphan

Consensus_repeat	Method
GGTCCTTATGTGTAGGTTTCTGGGCCAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021721_5

>merge|NC_021721|5|1948704-1948810|CRISPRCasFinder
GGTCCTTATGTGTAGGTTTCTGGGCCAGCAAACGCGTTTATGAGGAGCGTGAGCTAAACCGGAGCATAAAGTGGCCGCGGTCCTTATGTGTAGGTTTCTGGGCCAGC

>NC_021721|5|5|1948704-1948810|CRISPRCasFinder
GGTCCTTATGTGTAGGTTTCTGGGCCAGC	AAACGCGTTTATGAGGAGCGTGAGCTAAACCGGAGCATAAAGTGGCCGC
GGTCCTTATGTGTAGGTTTCTGGGCCAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021721.1\|WP_003566829.1\|1953182_1953557_-\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003566105.1\|1943845_1945822_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NC_021721.1\|WP_003566109.1\|1947038_1948505_-\|peptide-MFS-transporter	unknown	unknown	gnl\|CDD\|225646
NC_021721.1\|WP_003566087.1\|1938980_1940444_-\|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236426
NC_021721.1\|WP_003566103.1\|1943035_1943833_-\|pyrroline-5-carboxylate-reductase	unknown	unknown	gnl\|CDD\|223422
NC_021721.1\|WP_013245374.1\|1951777_1953022_+\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|225995
NC_021721.1\|WP_003566828.1\|1953696_1954119_-\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003566827.1\|1954681_1956112_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340890
NC_021721.1\|WP_003566083.1\|1936953_1937781_-\|ammonia-dependent-NAD(+)-synthetase	unknown	unknown	gnl\|CDD\|234831
NC_021721.1\|WP_020751591.1\|1948968_1951287_-\|ABC-transporter-ATP-binding-protein/permease	unknown	unknown	gnl\|CDD\|213222
NC_021721.1\|WP_003566107.1\|1946149_1946977_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|163441
NC_021721.1\|WP_020751592.1\|1957939_1959607_-\|phosphoenolpyruvate-carboxykinase-(ATP)	unknown	unknown	gnl\|CDD\|236471
NC_021721.1\|WP_003566081.1\|1935576_1936734_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_021721.1\|WP_003566101.1\|1941783_1942929_-\|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl\|CDD\|238434
NC_021721.1\|WP_003566085.1\|1937783_1938977_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NC_021721.1\|WP_003566826.1\|1956206_1957343_+\|alpha-L-fucosidase	unknown	unknown	gnl\|CDD\|214829
NC_021721.1\|WP_020751593.1\|1960024_1962136_-\|ferrous-iron-transport-protein-B	unknown	unknown	gnl\|CDD\|223447
NC_021721.1\|WP_003566823.1\|1959821_1959989_-\|FeoB-associated-Cys-rich-membrane-protein	unknown	unknown	unknown
NC_021721.1\|WP_003566825.1\|1957451_1957769_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131249
NC_021721.1\|WP_003566099.1\|1941057_1941759_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099

Protein	Function_ID	Function_description	E-value
NC_021721.1\|WP_003566105.1\|1943845_1945822_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	3.7026e-97
NC_021721.1\|WP_003566109.1\|1947038_1948505_-\|peptide-MFS-transporter	gnl\|CDD\|225646	COG3104, PTR2, Dipeptide/tripeptide permease [Amino acid transport and metabolism].	6.68207e-154
NC_021721.1\|WP_003566087.1\|1938980_1940444_-\|nicotinate-phosphoribosyltransferase	gnl\|CDD\|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NC_021721.1\|WP_003566103.1\|1943035_1943833_-\|pyrroline-5-carboxylate-reductase	gnl\|CDD\|223422	COG0345, ProC, Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism].	8.5867e-80
NC_021721.1\|WP_013245374.1\|1951777_1953022_+\|ISL3-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.20353e-51
NC_021721.1\|WP_003566827.1\|1954681_1956112_+\|MFS-transporter	gnl\|CDD\|340890	cd17332, MFS_MelB_like, Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily. This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.98331e-43
NC_021721.1\|WP_003566083.1\|1936953_1937781_-\|ammonia-dependent-NAD(+)-synthetase	gnl\|CDD\|234831	PRK00768, nadE, ammonia-dependent NAD(+) synthetase.	0
NC_021721.1\|WP_020751591.1\|1948968_1951287_-\|ABC-transporter-ATP-binding-protein/permease	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	5.89812e-103
NC_021721.1\|WP_003566107.1\|1946149_1946977_-\|metallophosphoesterase	gnl\|CDD\|163441	TIGR03729, acc_ester, putative phosphoesterase. Members of this protein family belong to the larger family pfam00149 (calcineurin-like phosphoesterase), a family largely defined by small motifs of metal-chelating residues. The subfamily in this model shows a good but imperfect co-occurrence in species with domain TIGR03715 that defines a novel class of signal peptide typical of the accessory secretory system.	5.64581e-118
NC_021721.1\|WP_020751592.1\|1957939_1959607_-\|phosphoenolpyruvate-carboxykinase-(ATP)	gnl\|CDD\|236471	PRK09344, PRK09344, phosphoenolpyruvate carboxykinase.	4.14138e-07
NC_021721.1\|WP_003566081.1\|1935576_1936734_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	3.83637e-45
NC_021721.1\|WP_003566101.1\|1941783_1942929_-\|N-acetylglucosamine-6-phosphate-deacetylase	gnl\|CDD\|238434	cd00854, NagA, N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to amino-sugar-nucleotides, which is needed for cell wall peptidoglycan and teichoic acid biosynthesis. Deacetylation of N-acetylglucosamine is also important in lipopolysaccharide synthesis and cell wall recycling.	3.42008e-156
NC_021721.1\|WP_003566085.1\|1937783_1938977_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	8.24724e-43
NC_021721.1\|WP_003566826.1\|1956206_1957343_+\|alpha-L-fucosidase	gnl\|CDD\|214829	smart00812, Alpha_L_fucos, Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis.	3.1847e-72
NC_021721.1\|WP_020751593.1\|1960024_1962136_-\|ferrous-iron-transport-protein-B	gnl\|CDD\|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	0
NC_021721.1\|WP_003566825.1\|1957451_1957769_-\|hypothetical-protein	gnl\|CDD\|131249	TIGR02194, Glutaredoxin-like_protein_NrdH, Glutaredoxin-like protein NrdH. NrdH-redoxin is a representative of a class of small redox proteins that contain a conserved CXXC motif and are characterized by a glutaredoxin-like amino acid sequence and thioredoxin-like activity profile. Unlike other the glutaredoxins to which it is most closely related, NrdH aparrently does not interact with glutathione/glutathione reductase, but rather with thioredoxin reductase to catalyze the reduction of ribonucleotide reductase.	6.08924e-12
NC_021721.1\|WP_003566099.1\|1941057_1941759_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	3.02871e-84

>NC_021721.1|WP_003566109.1|1947038_1948505_-|peptide-MFS-transporter
MNNSKDRTFMGHPRGLLTLSMTEFWERFSYYGMRAILIYYMYYAVEKGGLGFDQPTALSIMSIYGSLVYLSATIGGFISDRLLGSRRTVFWGGVLIMLGHIVLSLPIGATGLFGSIVLIVLGTGLLKPNVSEMVGSLYPEDDLRRDSGFSIFVMGINFGSLIAPIFVPWMADKVNFHAGFSLAAIGMFVGLIFYVIDGRKYINPADNTAPDPLKPEDVRPLVIRVVVAIAAVGVILLAMAGFNALTIANVISLITLIAIGLPIWYFVLMIRSKKVTKTERSRVIAYIPLFLAAMIFWAIEEQGSVVLALFAAQQTKLDFGFFKILPGNFQTLNPLFILLYGPLFAWLWMKLGKRQPTSPKKFYLGLIFAGASYLWMVIPVMLFGSSAKVSPLWLVMSWAIVEIGEMLISPVGLSVTTKLAPKAYSSQMMSMWFLADASAQAVNAQIVRFYTPNHEVAYFAIVGLVSVGFAVVLAFFTPRIEKLMQGVN
>NC_021721.1|WP_003566107.1|1946149_1946977_-|metallophosphoesterase
MVKIAFSVDNHFDVNRVDGFEMLKKQAAYLIEHDYQIYVNAGDTYNDFTKSLAYFRALQAEVGSAVTIRFLAGNHDMVNGATYDEIQSAVDPLYLHEKILPVPSTNAVIIGNNGWYDYSLGQLGNMKTDAEYAQWKRAFWIDSAIDAPVTDAARMQRVLTTTKAALQANQTHQMIYVTHFVPIREAMVYTVDRPPWQMATALMGSAKLGDLLTGRVSAVVFGHEHFRDAPKLLSGTTYYHQPLGYGLKRLFEWQSQDWWTEWRQTLVTLTVPTLS
>NC_021721.1|WP_003566105.1|1943845_1945822_-|S9-family-peptidase
MAIKATDLFKLVSLSYPSATDDGYFVQENRISEADNTYYQRICFVNHRGGTIAYGFDQKHDRHPLLSPDQQWLAFLSQASDKTTQVFLQAVNGGTAKQFSAEKEGVSYFGWQADSQALFIQTTVGAKPKKTDKQWPQPVTVSRVPYKLNGVGLLPEHVAYELRVQRLRQKTSRLVMGREHEFEVGAISPDGQTLAFTAERLPDDPNDFSQATYLLNLVDQQVTMVNDQLPQAALSPEAFSADGKQLLLVGSDNHLPNVSQSHLWHYDLATKTLQDVADDIDFDIPGHVNGDFQQDLSEKVADFATADYYLTIGFDHGKTSLYAGGPDEQLTPLIGGRRHVTDYALTPDHHGVVFTESTMTVPSRLSYFDLATEEEHVIYDPNRRVTRDMGLVTPQTFNFQRDGFEIEGWYFPPQQATASHPAILYVHGGPAVGYGYTFFHEMQFLAAQGYGVICPNPRGGLGYGEAFTAAVIKHYGQGDYEDCMASVDEALKLDTTIDPDRLYVAGGSYGGFMTNWIVTHTHRFKAAVTQRSIANWLSMYGTSDIGYFFTPWELEGKWTGDLSDVKSLWDFSPLAHIDFAQTPTLVMHSENDQRCPIGQGEEFYIGLKLHGVDTKFMRFPNATHELSRSGLPNLRLARLAALVDWFKTHSATEESHQA
>NC_021721.1|WP_003566103.1|1943035_1943833_-|pyrroline-5-carboxylate-reductase
MTIGFIGAGNMARAIITGLLAKNAVTPEEIVLHGGQPIHYEPYAAKIGAKAVASNQAVADTADIVFLAVAPKLGVPILKTIGPTLKQRQVPIVSMLTGVSLATLEDALGSQDQPVLRIMPNVNVAINAGMTAYAANDSVAGQLDGLLDLLNVLGKTMALPEDQFSTFVALAGSSPAFVYLFIDSLSRAGVKYGLTKKQATAIAAQAVMGSAQNVLASEQSPFDLIDQVSSPGGTTVAGLLAMEQAGLMSAVIKGVDATIAKDRQG
>NC_021721.1|WP_003566101.1|1941783_1942929_-|N-acetylglucosamine-6-phosphate-deacetylase
MTVTVLKHATIYTGLERIDDGYVRFDDKILAVGDMFDYRAQSGEQTFDLQGKTMIPGFIDVHAHGGYGFDAMDGDADQIDEMATKMMTHEGVTTLFATTMTQSTENIDKAMRGVKQAAERNHIIQGVHLEGPFISKVFKGAQPEEYIKNPNVDLVKQWQELSGGLVKLITYAPEDEGSQAFEDYLLAHNIVPSVGHSNATREQMLHSKATHVTHLYNAQRGLRHREPGVTGHAMLEDNMYCELICDGFHIVPDMLRLAFDQKGPERIELVTDSMRSKGMPEGKSELGGQTVYVKDKQARLKDGTLAGSVLMYKDAFKNAMSFMDASLFDAVEMSSVNQAREFNLTSKGTLEVGKDADINVLDRNNDLVATYSYGVKHDTED
>NC_021721.1|WP_003566099.1|1941057_1941759_-|GntR-family-transcriptional-regulator
MDAPVYIQIHNAIRADIEAGKWRVGDRIPSERDLAVTFKVSRMTLRQAIQTLVDEGILERRVGSGTYVANQKVQEKMSGVTSFTDLMQAQGKVPSSKTVSYHVAQPTSSEVEKLKLEPKEQVLRMERIRYADKIPISFETAAVPYNLVKNFTKKEMTASFYHTLEKKGGYVLGGAQQTVSAMLASERISEYLDIKRGEAILRLRQVSFLQDGTPFEYVRTQYVGERFEFYLER
>NC_021721.1|WP_003566087.1|1938980_1940444_-|nicotinate-phosphoribosyltransferase
MTTQLGEGLTLHTDFYELNMMNTFFEQGISERNAVFEVFFRDLPFGSGFAVFAGLEHVMDYLNHLKFSEDDLAYLQSQTDYSDAFIDYLRHLKFTCTVKSALEGDLVFNNEPIWQIEGPLAQAQLVETAVLNMINYQTLVATKAARIRSVAGADPLMEFGTRRAQETAAALWGTRAAYIGGFNATSNVLAGKEFGIPISGTHAHSLVQAYGNDYDAFKAYARSNKDVVFLVDTYDTLRSGVPAAIKVANEFKGKINFLGVRIDSGDMAFISKRVRQQLDDAGYESAKIYASNDLDENTIQNLKMQGAKIDIWGVGTRLITAYDQPALGAVFKLVSIEDAAGKMRDTIKLSNNAEKVSTPGKKQVWRITRQDDGKSEGDYVALADETIDTQRSLYMFHPNFPYINKTVKNFEAKPLLQTIYDKGQQVYHTPPLQEVQAYATRSTNALWDEYRRILNPQDYPVDLSQRVWDNKMDLIKAVKSAVADREE
>NC_021721.1|WP_003566085.1|1937783_1938977_-|serine-hydrolase
MRASKRRSQHRWLILSLLVGLVVGIAAYASYDHFYLKPQIEAKEERTRRKYEIELNRHRAVEQRLQNETRTATSATDKLMQPVNQAEAKPFMKILEANHFSGTALMIRRGKIILNTGLGYADAESGRLNGPETLYQIGSIQKGLTAVLLMRLVEQGKVHLSDPISKYLTGIRTGKQVTLRMMLNMRSGLSLTRAQSASLSDAGIVRWSIANLNYGTVRYDYQPVNYVLLAGVIEKVTGRLYADLIQQEIFKKLKLTHSGFMPELFHESNQAFGYSGPINNPYAKRYTEPSVNYNRELGTGNIYTSAGDLYQIIKAVNQGKIISTASLKALRNLDNGQYTAGVYNFGGYTLTHGVVASQSAGTMIDTSGQNAVVLLANTDKITQGLIKNLYLNMIKGV
>NC_021721.1|WP_003566083.1|1936953_1937781_-|ammonia-dependent-NAD(+)-synthetase
MRPLQAEIIKALGVQATIDPETEVRRSVDFLKAYLKKNTFLKTYVLGISGGQDSSLAGALTEKAMQEMRAETGDDAYQFIAVRLPYGEQADEADAMAAIDFMHADVVKRVNIKPSVDAMVAAVEADGSKISDFNKGNIKARMRMIAQYAIAGNNAGAVIGTDHAAEAVTGFYTKFGDGGADLTPLYRLDKRQGAALLKVLGAPAHLYEKAPTADLEDNRPALPDEVALGVKYKDIDDYLEGKDVSDQAAETIEKWYQKTAHKRHLPITVFDNFWK
>NC_021721.1|WP_003566081.1|1935576_1936734_-|serine-hydrolase
MSGKHRYIWLGVMLILCAVSIGAGTYLWQQNSRSAVNTKAKSAKTVTKVVRQDRGKSKEEILAMTLDRAATTTEGQPLEQELTNDKFIGSALIIKHGKVVFNNGVGDADTTTHRRNGPTTLFQIGSIQKAVTAVALAQLAASGKLSLDDPVGKYLTGIKTGDQVTLRMMVAMRSGFSLRRYQPTVMDDANIIQWSIANLTYLPQDNYAYQAVNYVLLAGVIEKVAGRSYEQQVKNNIFDRLNLKHTGFLPAMLTDPERAITYTGPAANPYQTAIGEPAVWYNRELGTGNVYTSTGDLYRLLRGIDTGKVLSLSTLKTLRNRNDGVYNAGIYNHADFYSTNGVVAGQMASTAISHDGQNAVILLSNYNSHALNLHDLAVHLFSELG
>NC_021721.1|WP_020751591.1|1948968_1951287_-|ABC-transporter-ATP-binding-protein/permease
MLDLKHIKKYYQTGDYTTKALDDVSVQFREQEFVAILGPSGSGKTTLLNVIGGLDRYDSGDLLLHGRSTKNFKEADWDAYRNNSVGFIFQSYNLIMHLSILENVELGLTLSGVSAADRRKKAEAALTKVGLKAHMGKQPNQLSGGQMQRVAIARAIVSEPSILLADEPTGALDTETSEEIMRLIADLSRERLVIMVTHNPQLAHEYAERTIEFKDGKILSDSRPFKDEEKTASFDLHRTKMSYFTALKLSFTNIMTKKGRTFLTAFASSIGIIGIAVVLALSSGFQKQIDNTQAETLAQFPITISTNATSLTAGAADNTKTSTFKTTSTVVAKQSASDKAQHTNKLNQKYIDYVNGISKKLTDNIGYTYGTGMNLLRDVNGTIKPVQFSTAKPSSNQTQRGLASASSSVYPVDREGGTSYLKKNYEVVAGSYPKHDGDVILIVDRDNSTNINALKNLGFDVKDGQKVKFNQIVGTKIKAISNNAYYQNVAGNVYVPTKGYANAYKQNDNRELTVAGVLRTRSKTSDGLLSQGFAYSDRLTKDLVALNKDSDVVKAQRASDVNIFTNQSVDKATKDQLITALGGSETPTQITIYPTSFKDKDKILSYLDKFNRGKKKADQVVYTDLAGTISSMTGGIMSAITIVLVAFAGISLVTSMIMIAILTYTSVLERTKEIGVLKALGARRKDITRVFDAETIILGVSSGILGIIIAWLLTFPINAILYSMTKLPNVAQLNPIHAVILILISTILTVLGGHIPARMAANKDAAIALRAD
>NC_021721.1|WP_013245374.1|1951777_1953022_+|ISL3-family-transposase
MSQYDPTLSVLGIPDHNIKVAFVRHEYRGNGVRRRQYHVIDAELTYRLTRCPLCGFEALHPNGFYTAHVRVLNGVEMPTVIDLHKQRWRCHNCYHTVSAKTPLVQPNHTIAAHMTERIMKLAHERLPVKTIARIIGISASSVQRIIDQNLKLRPARRLPTRLCFDEFRSTHGMMSFICLDADSHRLIALLGDRFNRTIKNFFIAHYSLADRTRVQTVTMDMNAAYQTIIHEVFPKAQVVIDRFHIIQLAARALDQVRVQALKQLDDKHSRPYKIMKTNWRLFHQTAPDAKHKQFLFGLNEYVTQQEAIDIALDTEPKLKQTYETYLALHDALMVKKHPAELANLLATYEPNGTAMDMTIATLKRHKVAVLAAVTSPYSNGPIEGVNRLIKSLKRSCFGFKNQLNFFKRIYQITA
>NC_021721.1|WP_003566829.1|1953182_1953557_-|hypothetical-protein
MAVWRMMFARPQFKHRQIKRMVDDLNREGNFGGMPIHRITLTRQTRELIYVDLEFQLTTGLTQPLFEQMAKYILVAVAGLAHAPQPIYLAAMANPFAKLNISYYIYPDHSLDLIYWQPLLREPT
>NC_021721.1|WP_003566828.1|1953696_1954119_-|hypothetical-protein
MHTRCQEPNYVEVVNQNLERLLVFETVFKEYVHTCKNIEKGNCYASESLDHLRLYFTKNVMKFCTFVDSVDAEAAPCNYAAFHKVLVNGLRGIRGGVLNMLQAIGTDKVDHDRFAAGLAEQQAARAEIDTAFSKILDPIF
>NC_021721.1|WP_003566827.1|1954681_1956112_+|MFS-transporter
MKGYPKQYPLDRQTLFGINTMGLMSTTAYYLYTAVLMMFITDYSGIYSGVPGKAAAVATTLLFVGRLWDAVNDLWTGYLIDISPRTRWGKFKPYVLIGSLLAGILGMMLFHIPQNLSNFGKEVYLYIVYFLFMFAATIIVTVPLTSTMSADQEVRAKLISWPRITSNIVGVVFAFFMAIATYLGTKRNPNIPLTVDLIVIPFLILSLIGIVMVKEGPVTEEAKPPRLRDIGQMIKINHPFRINLYFTFVGGFVWALLTATSLYYIKYAFGVKNLGTQSMYFGLLTLITLVAGTLISQKAMQYISAIRGVQWCYLAMAPFLVIMFIINEIHVIDNPWVFYLLIGIVMTIAGAQFVPANLIIMETMDYNRLKLNAGMEATINAVNMFLQKLQSGLATIGVGAALLIVGYNAQTLEKATHVPDNLLQSLGVVLFAIPAVFSFLAYLIARHYPLQGAARDEMYAALAAKQVTNTQSSKSK
>NC_021721.1|WP_003566826.1|1956206_1957343_+|alpha-L-fucosidase
MTKSSAVNIHRTNPPDWFKQADFGIIIHWGPYSVPAYAPVNIPDYGTLIKTKSLGYLFEHQPYAEWYGNSMLLPNSPVAAYHRTHYGNTSYADFAKTFKQTAQNVDVQAWAAAFANAGAKYVVIVTKHHDGFVMFDPHTNNPYEPDYHLNFDFVGELAQAVRAHGMRFGTYYSSLLDWTFPHLPIKDYGSFLLGNDKSQTYKDYVWHQWHELIDRYHPDVLWSDIGYPDDHRLETLFKYYYQQVPEGLVNDRWQQFPDWMRTSWIRPIFNLVAAQVIKRDQHHSDDLSEVKYYDYRTLEYRTDWPQTNRYFEMTRGMDKSFGYNRLSRPEDYITADDIKQLIAELRSKRGRLLLNVGPDMNGQIPSAQLSILQQLSDR
>NC_021721.1|WP_003566825.1|1957451_1957769_-|hypothetical-protein
MAIHFVIYEKPNCESCRLTKRWLAEHGQHFRTTNHRGESNLVDINANDPLKRAWSHQKIVKFREAGYDRFPVVRVRDDATGDVLATWSGFRPEALASWTAINQLG
>NC_021721.1|WP_020751592.1|1957939_1959607_-|phosphoenolpyruvate-carboxykinase-(ATP)
MTSKQSFSSSDITSQSGYFSALKATVETAFYGENVKQVTTIAQAYALAKTAPGVIITDLPIKHTAELGLPPDAKVLVANDGRVVGRTAAARQIIGQPDVDETKLAAIAREAVFLGSRKTFLRGDVTVGLSSDFAIKAHLMLPEAYANNLYTYLLNFQIDTPQRNAEYEQSRPLPEDDIYLYADPDWHDPAYPNGLAVFDPTHNAAIVLGLRYFGELKKGTLTLAWATAHRNGFVACHGGMKQYTRQDGDFTMAAFGLSGSGKSTITLASHGDQYPVKVLHDDAFVIDRQTGATTALEPSYFDKTQDYPLSDPGIQHFLTVQNVGVTLDAAGKKTLVTQDIRNGNGRTVKSRYVTPNRVDHLTESIDAIFWIMKDDTLPPVVKLEDPDLAAAFGVTLATKRSTAENVIGDVDRDHLVIEPFANPFRSYPLGEDYQDFHQLFEQRQTACYILNTGSYNGQNVKPADTLGAIAKIVDETAAFKPFGLLPKMRYLPLSGFNVDFGDNDYRARLRQRLEDRLAFIATKDVDHDGYDRLPIDASRALEDVIAALDQQAAAM
>NC_021721.1|WP_003566823.1|1959821_1959989_-|FeoB-associated-Cys-rich-membrane-protein
MATWIIGGIVVLIIAVVAYRTFFKKNKAGCSQCEEVGCPLIDHAKMVQANNRRKA
>NC_021721.1|WP_020751593.1|1960024_1962136_-|ferrous-iron-transport-protein-B
MAIRETLALVGNPNSGKTTLFNALTGAKQHIGNWPGVTVERKSGRLKADNALVIQDLPGTYSLSPYSSEEIVTRDFLLNDQPDLVLNVVDATNLERNLYLTLQVMETGRPLIVALNMMDVLVKTGYRTINLKKLSYALQVPVIATTATKPAALQELVQTIQAPLPKPYAFPEYDARFESALTMLEDVIDQKVPADRLRWYAIKVFEKDPQVVKQLAFSSDEQHQINEILRTAEHVFDDTTDSIIVNARYDFIARVIAMCVVDKDDFVMSMSDKIDRIVTDRYLALPIFVLVMWAVYYLSIQTIGTIGSDYLNDTVFGGWLPSVVGGTLKSWVVAPWLSGLIVDGLIGGIGSVLGFLPQIMMLFLCLGILEDCGYMARIAFVMDRLFHRFNLSGKSFIPILIATGCGVPGIMATRTIESEKDRRMSIMLTTFMPCSAKLTVIALVSGTFFPSNSWVAPSAYFMGIIAVICSGIFLKKTALFAGPPAPFVMELPAYHLPRLTNLYRSVMSRARAFVQKAGTIIFLSCVLLWFLSNFNFGLQMVDENDSMLRGLGTVIAPVFAPLGFGDWHATVATLAGLIAKENCVGTLHISFGAGSASGFGQALRATYPAMAGYAFLVFNLLCAPCFAAIGTMYKEFGDARWTWRAVGYQTGVAYLLTMLIYQGSLVVSGQASVMSIGLVLVAILLIVYGLLIKRPVPAIASSF

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Crispr_ID: NC_021721_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021721_6

2241041-2241130

Orphan

Consensus_repeat	Method
AAAACGGGCCCGAAACGGGCCCGTTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021721_6

>merge|NC_021721|6|2241041-2241130|CRISPRCasFinder
AAAACGGGCCCGAAACGGGCCCGTTTTTTAGAATTTTTAGGCAATTTTAGGGCTTTTAGCCCAAAAACGGGCCCAAAACGGGCCCGTTTT

>NC_021721|6|6|2241041-2241130|CRISPRCasFinder
AAAACGGGCCCGAAACGGGCCCGTTTTT	TAGAATTTTTAGGCAATTTTAGGGCTTTTAGCCC
AAAAACGGGCCCAAAACGGGCCCGTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021721.1\|WP_003566766.1\|2251229_2252045_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NC_021721.1\|WP_003606946.1\|2239710_2240895_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225906
NC_021721.1\|WP_020751680.1\|2245989_2247468_-\|sucrose-6-phosphate-hydrolase	unknown	unknown	gnl\|CDD\|273554
NC_021721.1\|WP_020751677.1\|2233757_2235356_-\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|280533
NC_021721.1\|WP_003571030.1\|2253615_2254056_-\|3-hydroxyacyl-ACP-dehydratase-FabZ	unknown	unknown	gnl\|CDD\|234568
NC_021721.1\|WP_016385714.1\|2243102_2244770_-\|alpha-glucosidase	unknown	unknown	gnl\|CDD\|200472
NC_021721.1\|WP_016386701.1\|2230161_2231382_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341153
NC_021721.1\|WP_003566764.1\|2250301_2251075_-\|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NC_021721.1\|WP_003566762.1\|2248064_2248940_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187578
NC_021721.1\|WP_020751676.1\|2232514_2233765_-\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|223804
NC_021721.1\|WP_016385188.1\|2227110_2227917_-\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_041168902.1\|2241138_2243100_-\|PTS-sugar-transporter-subunit-IIBCA	unknown	unknown	gnl\|CDD\|131051
NC_021721.1\|WP_020751678.1\|2235373_2238424_-\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NC_021721.1\|WP_003570994.1\|2225295_2226108_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|238915
NC_021721.1\|WP_016385189.1\|2227964_2230100_-\|DUF262-domain-containing-protein	unknown	unknown	gnl\|CDD\|377857
NC_021721.1\|WP_016385191.1\|2231429_2232356_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NC_021721.1\|WP_020751681.1\|2252210_2253575_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|236307
NC_021721.1\|WP_003571023.1\|2244844_2245846_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NC_021721.1\|WP_016386704.1\|2238894_2239461_-\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003566763.1\|2249020_2250202_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|225139

Protein	Function_ID	Function_description	E-value
NC_021721.1\|WP_003566766.1\|2251229_2252045_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	9.9706e-144
NC_021721.1\|WP_003606946.1\|2239710_2240895_+\|hypothetical-protein	gnl\|CDD\|225906	COG3371, COG3371, Predicted membrane protein [Function unknown].	3.70628e-06
NC_021721.1\|WP_020751680.1\|2245989_2247468_-\|sucrose-6-phosphate-hydrolase	gnl\|CDD\|273554	TIGR01322, Sucrose-6-phosphate_hydrolase, sucrose-6-phosphate hydrolase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	3.54098e-146
NC_021721.1\|WP_020751677.1\|2233757_2235356_-\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	2.38602e-131
NC_021721.1\|WP_003571030.1\|2253615_2254056_-\|3-hydroxyacyl-ACP-dehydratase-FabZ	gnl\|CDD\|234568	PRK00006, fabZ, 3-hydroxyacyl-ACP dehydratase FabZ.	1.55842e-74
NC_021721.1\|WP_016385714.1\|2243102_2244770_-\|alpha-glucosidase	gnl\|CDD\|200472	cd11333, AmyAc_SI_OligoGlu_DGase, Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins. The sucrose isomerases (SIs) Isomaltulose synthase (EC 5.4.99.11) and Trehalose synthase (EC 5.4.99.16) catalyze the isomerization of sucrose and maltose to produce isomaltulose and trehalulose, respectively. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomaltooligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. Dextran glucosidase (DGase, EC 3.2.1.70) hydrolyzes alpha-1,6-glucosidic linkages at the non-reducing end of panose, isomaltooligosaccharides and dextran to produce alpha-glucose.The common reaction chemistry of the alpha-amylase family enzymes is based on a two-step acid catalytic mechanism that requires two critical carboxylates: one acting as a general acid/base (Glu) and the other as a nucleophile (Asp). Both hydrolysis and transglycosylation proceed via the nucleophilic substitution reaction between the anomeric carbon, C1 and a nucleophile. Both enzymes contain the three catalytic residues (Asp, Glu and Asp) common to the alpha-amylase family as well as two histidine residues which are predicted to be critical to binding the glucose residue adjacent to the scissile bond in the substrates. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NC_021721.1\|WP_016386701.1\|2230161_2231382_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341153	cd17264, RMtype1_S_Eco3763I-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Escherichia coli O69:H11 07-3763 S subunit (S.Eco3763I) TRD2-CR2. Escherichia coli O69:H11 07-3763 S subunit (S.Eco3763I) recognizes 5'... TACNNNNNNNRTRTC ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	2.00567e-41
NC_021721.1\|WP_003566764.1\|2250301_2251075_-\|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	3.41574e-111
NC_021721.1\|WP_003566762.1\|2248064_2248940_-\|SDR-family-oxidoreductase	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.28315e-71
NC_021721.1\|WP_020751676.1\|2232514_2233765_-\|restriction-endonuclease-subunit-S	gnl\|CDD\|223804	COG0732, HsdS, Restriction endonuclease S subunits [Defense mechanisms].	3.72305e-16
NC_021721.1\|WP_041168902.1\|2241138_2243100_-\|PTS-sugar-transporter-subunit-IIBCA	gnl\|CDD\|131051	TIGR01996, Includes:_Phosphotransferase_enzyme_IIB_component, PTS system, sucrose-specific IIBC component. This model represents the fused enzyme II B and C components of the sucrose-specific PTS sugar transporter system. Sucrose is converted to sucrose-6-phosphate in the process of translocation into the cell. Some of these transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci, Streptococci, Lactococci, Lactobacilli, etc. which contain their own A domain as a C-terminal fusion. This family is closely related to the trehalose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively).	0
NC_021721.1\|WP_020751678.1\|2235373_2238424_-\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	1.1541e-121
NC_021721.1\|WP_003570994.1\|2225295_2226108_-\|sugar-kinase	gnl\|CDD\|238915	cd01940, Fructoselysine_kinase_like, Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the lysine side chains. Fructoseamines are typically metabolized by fructoseamine-3-kinase, especially in higher eukaryotes. In E. coli, fructoselysine kinase has been shown in vitro to catalyze the phosphorylation of fructoselysine. It is proposed that fructoselysine is released from glycated proteins during human digestion and is partly metabolized by bacteria in the hind gut using a protein such as fructoselysine kinase. This family is found only in bacterial sequences, and its oligomeric state is currently unknown.	1.54398e-56
NC_021721.1\|WP_016385189.1\|2227964_2230100_-\|DUF262-domain-containing-protein	gnl\|CDD\|377857	pfam07510, DUF1524, Protein of unknown function (DUF1524). This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	1.67253e-27
NC_021721.1\|WP_016385191.1\|2231429_2232356_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	5.34203e-40
NC_021721.1\|WP_020751681.1\|2252210_2253575_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|236307	PRK08591, PRK08591, acetyl-CoA carboxylase biotin carboxylase subunit; Validated.	0
NC_021721.1\|WP_003571023.1\|2244844_2245846_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	6.07957e-98
NC_021721.1\|WP_003566763.1\|2249020_2250202_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|225139	COG2230, Cfa, Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane].	1.20642e-113

>NC_021721.1|WP_003606946.1|2239710_2240895_+|hypothetical-protein
MAKETHHVVIPDAIMEDLDIKDGEQVEVTLKDKEAVIRPKRTDTGTQTISLRFFLIPTVLAGIAFLAYFIYFQILQVPMTGKNSIAQMVIVLGELSGIATFAVAYIQNHRQIHGRDHRRRYWRIFPTMLLSFAIILAFVTSVFFWVIGYMFEGVSFDIYTATGLFLLFISIVNYLMIYSALSISTSFITTLFLSTFVGGVIGAIVTNSSRQWWQHNVSFLGTNKALNAWQFNLTIAVSALLWIALVDYLFVPLMAHRKNDWRLITMRIMLTVAAIALLGVGLFPNNRGLMHILHTQSAWFLNYFIIGMIIAVRWLLPGVSREFLSTSYIIGGIIIFAAILFQFVHYLSLTAFEMIAFALAMSWIMLLLQNIHRLYQKDESTFVVTVTTDKVNAD
>NC_021721.1|WP_016386704.1|2238894_2239461_-|hypothetical-protein
MTEADHEIRYAEYMNMINMTYSEAVAYLLNKYGPVKDNYFNEKSYQRFLNGEIKSISKGKYARTSEGLYTHHVDENRAENLSDLRFIRHYQYPFSMHRKDRLVYADLIEHLILHAIIAKETDGRFGEKGYSVFLAPNVDQWFISKKMPDPEWMKAVYRRSFLTKEDAKRLLEQIDSGPRAKVARYYRI
>NC_021721.1|WP_020751678.1|2235373_2238424_-|type-I-restriction-endonuclease-subunit-R
MGATLESTFEKRLIEQLTRGISQWTYRPELKTEEDLWRNFRQKIEQNNVAVLDGHPLTEQEFRQIQNQLQFGTFYDAAKWLAGENGVAKVQVQREDATLGTVRLEVVRREDVAGGTSSYEVVNQIEMPKVFADYQNRRFDVSLLINGLPLIHIELKNADHSYMDAFRQIKKYLSDGMFNGIYSVVQMFVVSDPYHTRYIAPASGTKMNERFLTNWVDEHNQPVETLTDFTDQVLSIPQAHKMVTQYTVIDSIRKSLILLRPYQIHAIERVREATKHQVSGYVWHTTGSGKTLTAYKVARNLLQIPSIDKTIFIVDRVDLDQQTTSSCMAYAENDTIDIDETEHVRDLIKKLKSTDRTVIVTTIQKLNFVMRRFADKQGTRDYERLTKLKIAFVVDECHRAVTSRKQWEINGFFHHALWYGFTGTPIFEQNARKEEGNLPRTTAEQYGERLHEYTVKEAIHDGAVLGFQVEYINTIREDQLTELIAKRTGESLADVAKMDPVEMEKNLLSSDYLNKNHMWKVIEGIVNHSQKKLGLYNGRGNSYTALLTTSSISQAQKYYELFKELRAGKAPFTMNKRTSELLPDFPKVAITYSVTENDLDSTLNQDAMRKSIRDYNEMFGTSYSLENINLYNANINDRLARKQARYLSREEQLDLVIVVDRLLTGFDAPCLSTLFIDRKPMQLQNIIQAFSRTNRIFDKNKQYGQIVVYQLPNTFAKAVEDALILYSNGGENEVLAPEWRVAHNRLKKAASSLKKFKIDPSGPPISELPDATLKQFAKAFQGFDKGLAAAQVYSEYDSDEIQDEIAIDSQDIEAYTSAYQNVIDELKRRRQTEGPEEDDLDIEYELETVRQDTINYEYIVNLIQAYVSDSRDDKPAVSQKRVEEISNYVDRLKNNNEKLGTLMESLWRKIQANPKEFQNQNVQTLLQTMKNETIEHLVKDVATTWGADPAEALFYAENFDPKKESNPGEESLKRHMDYEMYKEKTENPVKKISYWREFKDAYSNLIREEILPLNQD
>NC_021721.1|WP_020751677.1|2233757_2235356_-|type-I-restriction-modification-system-subunit-M
MAQMTSQTLYQALWNSADILRSKMDASEYKNYLLGLIFYKYLSDRMVVYASDQLEEKTTDLDKAQQIYTDAYNDKDLHDDLISNVSDEFGYHIQPDLTFTALIDKIDHGTFQLEDLSQSFRDIEQSSEFFSGLFEDVDLYSRKLGATPQKQNQVISDVMKQISTLDLVGQNTNDILGDAYEYLIGQFASDSGKNAGEFYTPQSVSRLITQIAMHGKEDVRGFTIYDPTMGSGSLLLNARRYSNERLSINYFGQELNTSTYNLARMNMILHGVPINNQHLHNADTLDQDWPIEEPTNFDAVVMNPPYSAHWQPSKGTENDPRFVSYGLAPKSKADFAFLLHGYYHLKDTGVMCIVLPHGVLFRGGAEGRIRKALLENGAIDTVIGLPANIFFNTSIPTTVTVLKKSRTTRDVLFIDASKEFEKAKNQNHLTGDNIQKILETYINRKDVDKYAHLASFDEIKENDFNLNIPRYVDTTEPEKPVDVVKVVADIKKNDEEIARLSSELAKDFDDLVANNDEAAKQLAALKELFKNE
>NC_021721.1|WP_020751676.1|2232514_2233765_-|restriction-endonuclease-subunit-S
MSKDAKNVPALRFRGYSDAWEKRKWSQLVGISKNMVDPTTGKYDSLIHIGPGNIRSNSRELVDLKTVKDENLISGKFHFDKGDIIYGKINPQLAKYTIAPAEGLSSADTYVLKPKSGIERLFLYYTLGTNRFFKYTVSVSQRTGMPKINRDELNAYSLIIAPSLFEQKRIGLFLRKTDDLIAATQDKLSFLKKMKMFFLQQIFPTKNHDVPQIRFDGFTDVWSHYKLGSLMRIDKEQEVKKELLTDIQKGFYVLAMRTFSMDGYIDHSKPYWLNHLDNVSDDKFLLPREFAILDADMDANLPKIGRVLLNASSEKYLLAAHVRKIQVKSGNDPIFIYALMRGNSVHERLKLEANGSISKRLLDKNVYKQSILVPNRSEQSKIGRLFFLLETTITLHQQKIQMLKQVKKSCLQNLFI
>NC_021721.1|WP_016385191.1|2231429_2232356_-|site-specific-integrase
MNLRTQKFHMYFKQWIELYKEGAVRPVTYQKYQMSHKHLATLAPDLHMDELKRRTYQELINEFAANHEKQTTLDFHHHLKAAILDALDEGILEQDPTRKVVIKGTVSRLHKVKFLNQHELTKLLALLDLDHGLDWDYFLLLIAKTGLRFGEALGVTPMDFDMAKLTLTINKTWDYKSAAGSFAETKNTASVRKVPLDWQVAMQFATQIKSLPQDKPIFVTDGQRVYNETANDILERKCKRASIPVISIHGLRHTHASLLLYAGVSVGSVARRLGHANMSTTQKTYLHIIQELENQDNDKIMRYLTSLM
>NC_021721.1|WP_016386701.1|2230161_2231382_+|restriction-endonuclease-subunit-S
MVVDVFEVLLARNAWEKRKWSQLVGISKNMVDPTTGKYDSLIHIGPGNIRSNSRELVDLKTVKDENLISGKFHFDKGDIIYGKINPQLAKYTIAPAEGLSSADTYVLKPKSGIERLFLYYTLGTNRFFKYTVSVSQRTGMPKINRDELNAYSLIIAPSLFEQKRIGLFLRKTDDLIAATQRRIDALEQAKKALLQRLFDQSWRFKGYSDPWEKRKLGETNSYFTDGNYGESYPKESELSDKENGVPFLRGSNLRNGELIEDNANYITKEKHAELTSGHLVEDDIVLAVRGSLGALGYVKDENIDWNINSQLAVIRTDKSELSGKFLVQFLLSWRGQKELLSRNTGTALKQLPIKQLKDVPVPIVNLDEQKEIGALFSSIDNLIAATQSRLSSLELLKKSLLQDLFI
>NC_021721.1|WP_016385189.1|2227964_2230100_-|DUF262-domain-containing-protein
MLIKLNLPAKYYFGVTIVKGNAELIVSQVIANNRTINIPVYQRRYSWRREQLERFVADLKTAYANQRERYFFGSLILNATGDTSTVDVIDGQQRLTTVSLFLIAIRDFLGSSDVDYQRVNEMFLIDRFDRDSIAKNRLHPVPGDEEQYVDVLVNGMSAADTIFKSTYAYFWNVLQQGDLTVREWLSLLEQRLQVMNIVVDQYDDAQLIFESLNSTGMNLTESDKIRNFLLMGLKGDQQAAAFQLWQQNERLVGSEELSRFYRQYLTSLARSSKPIKENEIYSDYRRYVGLTKDFDQIAQLKKEQAAAKLFAEITAPANVDIKDQRVKSLLIRLGHLNNDILVPYLLQVFAKTRDGVLSADQLVEVLRVLLAYLARRLFIGVPTTGLNLLFAALDRQVEHYVDQAKVDYVEGLKLVLTQVVKENKRFPTDQSLKDALVEKDYYHMSSMSLWFILDELNNASGEEQDLFDAAQSGKYSIEHIMPRVVNSSWQKALGTDWRLVHNVWLNRLANLTLTGFNGQMSNRPYIEKRDMADGYRKSGIKLNQWVAQFDKWDEATLQERQADLLTRALTVWPRPNVSTQLATDDPNSWDTLDMILEANPTGTKPVAFSFVDDQVVQIKSWTDLYNQLIDLLWDADPSNFFAMANSDESLVKHVNEVEADQRYRQLGDSDVAVYAGGDSALGRVQHIKRLLAGSDHDLSEVNVKTRQVSHS
>NC_021721.1|WP_016385188.1|2227110_2227917_-|hypothetical-protein
MSPIDTINRVINMISLVILLFYIVKTYRQVRSLDFLDYFVLYLKHRQTIYAEMQRNPQMRQKQLLSLFVSLMILTFWVIGSLEKLMTAWSLGNLINALIVLWLFGYFLYQTWQTKYLNEQNRYLTFANHFQRQHFNDVMAVFKRKLTAWSAEDDEDVLARERFQRLFDRVSEQARRHRKNAMLSDDMYALFDDQLLLRADSKPLTGREKKLLSYYVGYWDAGPYNDYSLSMIEEMDDQERRIVTKVLNVTMAMMGLGLVLLAIRQILG
>NC_021721.1|WP_003570994.1|2225295_2226108_-|sugar-kinase
MKVIAIGDNVVDLYPADKQMYLGGHAANTAVFAAELGLQAAYIGTFGNDARGDFARRMLVERGVDVQHSLQYAGRNAFTTITGKDGARRKVVGEPPQELRLDPEDIAYINSFDLVYLNSESHADAFLQAITARKVYDFSILDDDKLFKKIAPQIDLAYLSGKARSDDDVEALMRRVAAAGCDRIVCSRGLRGSAALVDGMMSWQQALGVKAVDSLGAGDAYITSFAATLYSSSKPTLDAKVSESLSHAAKFASAQVLLPGSFGHGAPLLS
>NC_021721.1|WP_041168902.1|2241138_2243100_-|PTS-sugar-transporter-subunit-IIBCA
MAKNYEEEAKAILKLVGENNVDSVTHCQTRLRFVVKDRKAIDDKALEKLPEVKGVFYGSGQYQVIIGTGVVNDVYASIAKLGTVNAIYGKDDADTAGKTSNEHKTVVQRLMAMLSGIFIPIIPVIAATGLFLGLKSAATNAQVLKLFGAVPSDIPASLTSVISVLTDTVFAFLPALIVWSTFRYFKGTPIIGIVIGLMLVSPILPNAYSVADGSAKAIMLFGWLPVVGSQGSVLTALVAGFTGAKLELFFRRHMPNVLEQILTPFLTMLVTFAIMIMGVGPIVHAIESGMLVGVEAVIHLPFGIGGFLIGAAYPLMVLIGIHQTMIAIETSLLASTGLNPLITLEAMYGFANLGVALAIFLRARSNKAKATSMGAFTSQLFGVSEPTLFGVLIRYNFRPLIVTVLTSGIGAAILSMLNVAANSYGLAVVPSYLMYIYNGHALLWYTIVSLGTVVAAFVATNAFAIPKEVLTPDGDVETANAVISSIVSDNKVYAPVGGETVALDQVSDPVFASGMMGEGMAIKPAEPGINKVYAPQAGTLSVVADTGHAYGLTTDDGMEILVHLGIDTVNLKGAPFTVAVKAGQHVNKGDLLGTFDQAAIKKAGLDATTIVLITNSKSYARIEPVAADTTVQAGADLLAVQREDVKVESVEPA
>NC_021721.1|WP_016385714.1|2243102_2244770_-|alpha-glucosidase
MTNETSRTWWQQEIFYQIYPASFKDSNNDGIGDLPGITAELPKLKKLGITTIWLSPVYKSPMVDNGYDIADYQAIDPRFGTMADFDQLMATAKDLGIKVVMDLVVNHTSDQHRWFQAALKDPASPYRDFYIFRQGHDGQPPNNWRSNFGAGSSWTAVPGEPNTYYHHVFSPQQPDLNWENPKLRKAIYSMINWWLAKGLAGFRVDAITFIKKDQDFASITPDGSDGLGKVKRKTENRPGLDQFLKELNAATFKPANAVTIGEASGVAYDQLGDFIGENGYFSMIFDFHYADIDVASGSEWFKQTNWTPKMLGEAIAKSQLAIQKVGWGANFLENHDQPRSLSKYIREPQYRNAIGAKALALIYFGLRGCPFIYQGQELGMVNAVRTNIDQFNDLSAHDNYRRALAEGYSEADALACVNRRSRDNARTPYPWDDSQNGGFNAGHEPWLPLTKQAAGVNWQAEHDDPNSVWTFYQTLCRLRNASPLRADLIEGDFAPLDAHNDNVIAYARGQHVQIFVNLSSKPAVVDLPAGHVWLNNYPDVGTSLQPYQAILIEVK
>NC_021721.1|WP_003571023.1|2244844_2245846_-|LacI-family-DNA-binding-transcriptional-regulator
MATISEIAKAAGVGVTTVSRYLNHHPYISAEKRARIEKAIHQLGYTPSAAATSLRAQATGNIGVLVSRVTNPFFAGLFDAIERELHAHGYQVMITQTYDDPEAEERFLKQLKSRELDGVILASVEAPDRVAAVAKAFPGRVVVVNADVQIPGATSLVLPHYQATRDALDYLFNQGHRRFAYVSGGTISGAHHGQSRTQAFLDFMQAHQLLVAQDLLFGQIHTAKEGQAIGKQLASLGPNVRPDAVFTNSDEVAVGVIDSLLAADVKVPDDIAVMGYDDQPFAPFAKIPLTTVHQPVASMAAAATHELLKGLGRQVAQDTQPTLHLSLKIRQSA
>NC_021721.1|WP_020751680.1|2245989_2247468_-|sucrose-6-phosphate-hydrolase
MKEATWSTAARYQPYSSWAPDYIMKLKAQVAASKWRTKTHVQPDTGLINDPCSLNFFNNKWHLYYQQFPFGPVHGLKSWAHAVSKDLFNWRRVPGDLLPDNEYDSHGAYTGSALVTHGTLRLMYTGNARDDQWHRHSTQLGAVLGADGRLFKDPKPLILTPPAGYTQEFRDPFLFNYAGQTYVLIGGQRPDHTGAILLYAKQTDKSWRFVAPLSIPDEFCGYMVECPNITFINGKVVLVYCPQGLDQDFFEYENVYPNIALVADNFDPATGNLTHQRLQNIDKGFDFYATRLANTDDDGTLAISWLGLPDTTYPTDDDGWAGVLSYVRQLTLRDDHVCLYPHPAIKNLRETAVEDQPVVQQHDDEWTVTNLEGAFELAFTLAAGQKTTIHLPDGDHDQLLIHLDSDSGQGMIQRENRNNGGSLRQFGFPAGKTVEIRLFIDVSVFELFIDQGYRVVSGRFFGNEAPTAARITPPSAASDVVSWNLKKDNGGL
>NC_021721.1|WP_003566762.1|2248064_2248940_-|SDR-family-oxidoreductase
MTNLLVIGATGNIGQPLIRDLQDDPDVHLFAGVHNSEHAKQALNGLKVQVRRFDFLDPATFEQALADIDKVFFVRPPQLAKPKEDMYPFLDALVARHVKQVVFVSLLGVAHNPMTPHHQIEKRIVELGLPYTFIRPSFFMQNLNTTHQADIVGHRDLFVPAGHARTSFIDTRDIGATAAVVLRDPAYIGQKLDITGAQALTYADAAQIMTMELGVPITYSKPSLWRFRKVMLQRGLPKNYVNVMVMLYLITQLGNAKTVTTTLPNVLGRPAISFEQYVHDYRAEFLPKPLS
>NC_021721.1|WP_003566763.1|2249020_2250202_-|class-I-SAM-dependent-methyltransferase
MLEKKFYHTMFSHSFNIPVRVDYWDHTEETYGTGEPTITIKMKKAIPVRDLLKNASLALGEAYMRGDIEVLGGTRPLQQLIAAAYANAGSFMRNKKLMRFLPKQSHTEHKSKEDIHSHYDLGNDFYKLWLDPTLTYSCAYFEDWSDDLETAQLNKIDHILRKLNPQPGRTLLDIGCGWGTLMLRAAKTYHLKVVGITLSKEQFKLVSDRIESEHLSDVAEVLYMDYRELNREPFDYITSVGMFEHVGKENLEGYFKDVAKLLKDDGVALIHGITRQQGGAVNAWINKYIFPDGYVPGMAENLNHIVDAGMQVADLEPLRRHYQHTLEIWDTNFNNHRNPIQQKFGYEFTRMWDVYLQAAAASFESGNIDVMQYLISKGPSGKDLPATRAYMYE
>NC_021721.1|WP_003566764.1|2250301_2251075_-|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-alpha
MTDKETLAYETVQAARAPRPYRTRELINGLVTNFHEFHGDRSSHDDPAVIGGIGWLDQQAVTVIATDKGQDLTERLQTHFGSPEPWGYRKALRLMKQAAKFHRPIVTLINTPGAYPGKEAEANGQGAAIADLLYTCADLPTPILAILIGEGGSGGALALAFGDEVWMTDKSMYSILSPEGFAAILWKDASRAKEAAAVMQLTPQDLLAKAVCDRIIPDTGTTFATTLKAAIKPKLAELVATDPQALIAKRQQRFRKF
>NC_021721.1|WP_003566766.1|2251229_2252045_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MSQPQLTQEALAREAALPENLWIQCPYCKQGSYRESLGNAQVCPHCHYGFRITAKKRLSLIATATEEWDADLVTSDPLDFPGYTEKLAAGQAATGLKDSVWTGQATIGGQSCALGIMDPKFMMGSLGTVTGERLTRLFEKATSANLAVVLFCASGGARMQEGIHSLMQMAKVSAAVKAHSNAGLLFISVLTDPTMGGVTASFAMQGDITLAEPHSLIGFAGRRVIEQTINQKLPQNFQRAETLLQSGFIDAVVQRQDQPSYLGDLLALHTA
>NC_021721.1|WP_020751681.1|2252210_2253575_-|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MFKKVLVANRGEIAVRIIQTLREMGITSVAVFSNADRHSLHVTLADEAICIGGPRAADSYLNMRNVVSAAILSGAEAVHPGFGFLSENAEFAKLVTDAGLALIGPKPTAIDQMGDKAVARQTMIDLGVPVIPGSHPLQDVETALAAGEAIGYPLMLKASAGGGGKGIRKLTDAAALKAEFAGAQAEAQAAFGDPTMYLEKVIVPAKHVEVQVLRDMHGHTSVFPERDCSLQRHSQKMVEESPCPVLTSPERRKLLHLAATIAEGVDYLNAGTIEFLMDQQHHFYFMEMNTRIQVEHPITEMVTGVDLVQAQLRVAAGDEVALTTPEPSGVAIECRLNAEDPYHDFRPDVGTLEQLRFPTGGMGLRVDTGVAPGDKISPYYDAMIAKLIVHGRTRDEALAKMHRALIELHVEGVKTNRDFALALFQAPTVLAGKADTAYLNRDFLPKWQSVSRPV
>NC_021721.1|WP_003571030.1|2253615_2254056_-|3-hydroxyacyl-ACP-dehydratase-FabZ
MLETKKTLEAQEIQAILPHRYPMLMVDRVLDLKPGESVVAQKNVSINEQIFQGHFPGNPIFPGVLQIEAMAQAGAIALLSMPDFKGKTAYLGGIKKAKFRHMVRPGDVLRIEVTLEKLIDNAGLGKGKIYVGENMASSADLVFAIG

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Crispr_ID: NC_021721_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021721_7

2338790-2339551

TypeII

Consensus_repeat	Method
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CRISPRCasFinder
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CRT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	PILER-CR

11 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NC_021721_7

>merge|NC_021721|7|2338790-2339551|CRISPRCasFinder,CRT,PILER-CR
GTCATTTAAATGATTGATTCGACATCTACCTGAGACCGCATATCACTGAGCATGTGCGAGATCGTCGCTCTTGAACTGATTGATTCGACATCTACCTGAGACGGACTGTGCGGCATGGTGTACGTTTAACGTGCTCTTGAACTGATTGATTCGACATCTACCTGAGACCCGTGCGCAAAGAGAAACGATACAAAGTTCGCTCTTGAACTGATTGATTCGACATCTACCTGAGACCCAGTTTCGTGAGACAGAGCGGTCAACGTTGCTCTTGAACTGATTGATTCGACATCTACCTGAGACCAAGACTTGGCGACTAATTACAATAACACGGCTCTTGAACTGATTGATTCGACATCTACCTGAGACAGTAAAAAATGTGCCTTCGCTGGCTTTCATGCTCTTGAACTGATTGATTCGACATCTACCTGAGACCAATACCCGTGCCAACGCTGCTATGAACAAGCTCTTGAACTGATTGATTCGGCATCTACCTGAGACGGACCAACTGGTAAAGACGGGGTAAGCCTCGCTCTTGAACTGATTGATTCGACATCTACCTGAGACAAGGGGCGTCTTTCTTTATATCATCGGCTTGCTCTTGAACTGATTGATTCGACATCTACCTGAGACAAATCGATTAAGGAATTCAAGCCAGATAGCGCTCTTGAACTGATTGATTCGACATCTACCTGAGACTTAGCTTGAATGAGGTTCGCGAACGTTTAGGCTCTTGAACTGATTGATTCGACATCTACCTGAGAC

>NC_021721|7|7|2338790-2339551|CRISPRCasFinder
GTCATTTAAATGATTGATTCGACATCTACCTGAGAC	CGCATATCACTGAGCATGTGCGAGATCGTC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	GGACTGTGCGGCATGGTGTACGTTTAACGT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CCGTGCGCAAAGAGAAACGATACAAAGTTC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CCAGTTTCGTGAGACAGAGCGGTCAACGTT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CAAGACTTGGCGACTAATTACAATAACACG
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	AGTAAAAAATGTGCCTTCGCTGGCTTTCAT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CAATACCCGTGCCAACGCTGCTATGAACAA
GCTCTTGAACTGATTGATTCGGCATCTACCTGAGAC	GGACCAACTGGTAAAGACGGGGTAAGCCTC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	AAGGGGCGTCTTTCTTTATATCATCGGCTT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	AAATCGATTAAGGAATTCAAGCCAGATAGC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	TTAGCTTGAATGAGGTTCGCGAACGTTTAG
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC

>NC_021721|7|1|2338790-2339551|CRT
GTCATTTAAATGATTGATTCGACATCTACCTGAGAC	CGCATATCACTGAGCATGTGCGAGATCGTC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	GGACTGTGCGGCATGGTGTACGTTTAACGT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CCGTGCGCAAAGAGAAACGATACAAAGTTC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CCAGTTTCGTGAGACAGAGCGGTCAACGTT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CAAGACTTGGCGACTAATTACAATAACACG
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	AGTAAAAAATGTGCCTTCGCTGGCTTTCAT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CAATACCCGTGCCAACGCTGCTATGAACAA
GCTCTTGAACTGATTGATTCGGCATCTACCTGAGAC	GGACCAACTGGTAAAGACGGGGTAAGCCTC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	AAGGGGCGTCTTTCTTTATATCATCGGCTT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	AAATCGATTAAGGAATTCAAGCCAGATAGC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	TTAGCTTGAATGAGGTTCGCGAACGTTTAG
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC

>NC_021721|7|1|2338856-2339551|PILER-CR
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	GGACTGTGCGGCATGGTGTACGTTTAACGT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CCGTGCGCAAAGAGAAACGATACAAAGTTC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CCAGTTTCGTGAGACAGAGCGGTCAACGTT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CAAGACTTGGCGACTAATTACAATAACACG
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	AGTAAAAAATGTGCCTTCGCTGGCTTTCAT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	CAATACCCGTGCCAACGCTGCTATGAACAA
GCTCTTGAACTGATTGATTCGGCATCTACCTGAGAC	GGACCAACTGGTAAAGACGGGGTAAGCCTC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	AAGGGGCGTCTTTCTTTATATCATCGGCTT
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	AAATCGATTAAGGAATTCAAGCCAGATAGC
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC	TTAGCTTGAATGAGGTTCGCGAACGTTTAG
GCTCTTGAACTGATTGATTCGACATCTACCTGAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021721.1\|WP_003571196.1\|2332727_2334419_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|227321
NC_021721.1\|WP_020751688.1\|2330104_2330962_-\|PRD-domain-containing-protein	unknown	unknown	gnl\|CDD\|170086
NC_021721.1\|WP_013245323.1\|2337965_2338721_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225511
NC_021721.1\|WP_003571194.1\|2331099_2332731_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_021721.1\|WP_003571221.1\|2346660_2347827_-\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_003571191.1\|2327814_2329653_-\|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|273919
NC_021721.1\|WP_003571210.1\|2339575_2340253_-\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
NC_021721.1\|WP_003571219.1\|2345865_2346660_-\|hypothetical-protein	unknown	unknown	unknown
NC_021721.1\|WP_020751691.1\|2349013_2350741_-\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|227320
NC_021721.1\|WP_003566920.1\|2325501_2326068_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_021721.1\|WP_003586314.1\|2340249_2340555_-\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
NC_021721.1\|WP_123796487.1\|2337093_2337990_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_021721.1\|WP_003571189.1\|2326194_2327643_-\|family-1-glycosylhydrolase	unknown	unknown	gnl\|CDD\|236580
NC_021721.1\|WP_020751689.1\|2341628_2345717_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	mkCas0193_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
NC_021721.1\|WP_003571223.1\|2348050_2348425_+\|YxeA-family-protein	unknown	unknown	gnl\|CDD\|377665
NC_021721.1\|WP_003571199.1\|2334615_2335041_-\|NusG-domain-II-containing-protein	unknown	unknown	gnl\|CDD\|227646
NC_021721.1\|WP_003571227.1\|2350721_2352464_-\|thiol-reductant-ABC-exporter-subunit-CydD	unknown	unknown	gnl\|CDD\|227321
NC_021721.1\|WP_003571214.1\|2340532_2341438_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NC_021721.1\|WP_020751690.1\|2348618_2348942_+\|DUF4870-domain-containing-protein	unknown	unknown	unknown
NC_021721.1\|WP_003566934.1\|2335191_2336292_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021721.1\|WP_003571196.1\|2332727_2334419_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|227321	COG4988, CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	4.89349e-93
NC_021721.1\|WP_020751688.1\|2330104_2330962_-\|PRD-domain-containing-protein	gnl\|CDD\|170086	PRK09772, PRK09772, transcriptional antiterminator BglG; Provisional.	2.77361e-35
NC_021721.1\|WP_013245323.1\|2337965_2338721_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.18451e-08
NC_021721.1\|WP_003571194.1\|2331099_2332731_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	4.64472e-93
NC_021721.1\|WP_003571210.1\|2339575_2340253_-\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	7.08547e-78
NC_021721.1\|WP_020751691.1\|2349013_2350741_-\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|227320	COG4987, CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	2.43029e-157
NC_021721.1\|WP_003566920.1\|2325501_2326068_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.93685e-11
NC_021721.1\|WP_003586314.1\|2340249_2340555_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.69699e-23
NC_021721.1\|WP_123796487.1\|2337093_2337990_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	8.10657e-39
NC_021721.1\|WP_003571189.1\|2326194_2327643_-\|family-1-glycosylhydrolase	gnl\|CDD\|236580	PRK09593, arb, 6-phospho-beta-glucosidase; Reviewed.	0
NC_021721.1\|WP_020751689.1\|2341628_2345717_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	1.08208e-117
NC_021721.1\|WP_003571223.1\|2348050_2348425_+\|YxeA-family-protein	gnl\|CDD\|377665	pfam06486, DUF1093, Protein of unknown function (DUF1093). This family consists of several hypothetical bacterial proteins of unknown function.	2.71411e-19
NC_021721.1\|WP_003571199.1\|2334615_2335041_-\|NusG-domain-II-containing-protein	gnl\|CDD\|227646	COG5341, COG5341, Uncharacterized protein conserved in bacteria [Function unknown].	6.99799e-34
NC_021721.1\|WP_003571227.1\|2350721_2352464_-\|thiol-reductant-ABC-exporter-subunit-CydD	gnl\|CDD\|227321	COG4988, CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
NC_021721.1\|WP_003571214.1\|2340532_2341438_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	5.52602e-86
NC_021721.1\|WP_003571191.1\|2327814_2329653_-\|PTS-glucose-transporter-subunit-IIA	gnl\|CDD\|273919	TIGR01995, beta-glucosides_PTS_EIIBCA, PTS system, beta-glucoside-specific IIABC component. This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.	0

>NC_021721.1|WP_013245323.1|2337965_2338721_-|helix-turn-helix-domain-containing-protein
MRRKGIRYSLEEKIQFVNRVLSGQSLMDVQRSGGPRHVALGRWVHSYQQWGAAGLVPKKRATRRHPRKHKTYSREFKLQIVQEYLAGGTSYPKLCAEYDISNPAVVYQWVSLYNSGQLLQTTRGSAPMTKGKKTTYVERIEIAQWIIAHDMDYQGAIKHFGVSYGQVYSWVKKFRESGEEGLKDRRGQHKPENTLDENQRLKLENKQSKARIDYLETENALLKKLQNVERRSAGNNTDNTNILPFKNSPKR
>NC_021721.1|WP_123796487.1|2337093_2337990_-|IS3-family-transposase
MQELTQEVTRVTKRYHSVSLCCQIFDIPRSAYYKWLHREPTKQDIMNTELVRFIKKLEEDNHYIYGVDRLRMIINQETDYHVNPKRVRRLMQDNGIQCSIRQKKHDRVAEKKEYILGNKLLNQDGSHAFHPTRPNEVWVTDCSELTYGFNSECHLRLSAIKDLYDHSIVAWEVEPSETATLVTQTFRAAAEAEETLPELLHSDQGSGYTSRLYNTELAGSGVIHSMSRPGTPGDNSPMESLWSHAKTEYFDFVHANTYEEMMQFIEEYVLWYNGDRHQETLNGMTPAEYRNHAIETAA
>NC_021721.1|WP_003566934.1|2335191_2336292_-|hypothetical-protein
MKKLIVLSATLLVSMGLAACSSGSSSSSSKSSSTTSQTSNAKVKINTGADASAKVPAAGTLVMRQLYAAPHGKQSFAAVNVTLNGDTIVSAKIDEFQYVKKSSDWTGVPNSNKDFGKSYPKGQFLIAKAENSKPYSALMKKEAKATHTWEENETAITNFVKGKKIEDLKADVAKVKDTKKVSDVVSGATFADTAGYLQAIYDAATTGMVAEGIQTTDNTITEGQVLAAPHGTQSFGIVTVAMQGDKIANVFLDEFQYMPSKDFGGVPNSNADFGKGIKSGTVLASKRANSEAYSAIMKSKGKATQTWQENSNAIDEFAKGKTIAELETAVSDLKGKKKVSDVVSGATFTDTSGYLTAIISAAKAAK
>NC_021721.1|WP_003571199.1|2334615_2335041_-|NusG-domain-II-containing-protein
MRWLKKYVRPFDYVIVIVLFVACFLPVGIFSLTEANVNTNQKVAVISINGHVKRRIQLTTHTRHQQFTLYPAKGQYNIIEVQGARIRDKEDNSPDQIAVHTGWISQVGQQSICLPHKLLIEIKPAQAGTGTSGDTGGLVHP
>NC_021721.1|WP_003571196.1|2332727_2334419_-|ATP-binding-cassette-domain-containing-protein
MLGLLKYGRDQRWAGVIETVFDWLPTLLPIMIALNFAAKRPGNALIITVILVLIWLGYVIGYERHHRHAWAMSAKRELRDHYFEALYQRNNAGDATAADNAVIQRDLGGLNNLDMFYSTLFPTLIQAGLTFLLLIGLSVWYGSWLAFLPLACVFLIGFAMMFLGKKMSAQNKAHLAGFLRMGGRFMNDLSGMNTLVMYNAADRYAKKFADDSEYFRQATMNLLRTQLQVLFVINGFVYLTVFAGGFVTALQLAAGQLPAAGAFATWFALAMMMVNARQLGYFFHVVKSNGPALAGILATIAKSKTTPATVKITDNRPLKQLVLQDVAIGYEADAPLVSDINATLVPGKLYGLAGENGTGKSTLTQALLGQLTPLSGTIMADNTPVTALSNAQRAAVFGYVAANDYIFSGTIKENLLLGNQFGDQWQQHLDELGLMHFVTDLQDGYATEVGEGGRLLSPGQRQQLAFARMLLADKTVYLLDEMTSSIDAANAAIILAAIKRLSRQKIVLFISHDLSAMAEADVVWFIHDHQLISADHAQLYRDQPAYRHLVDNPEAMLKEGQPS
>NC_021721.1|WP_003571194.1|2331099_2332731_-|ABC-transporter-ATP-binding-protein
MIRSLLRYTHHLTGAIIISFLIGLVAELTKVVVLVLAAMMLFDPQNASHLLIPGIIAVVIVGLGSFGEQYAGHFVAFHVLAELRGAVYRKLVQLAPAKLDSQGSGKLLKLIGSDIEAMEIFYAHTIVPVAIGLIYGVLMVAVYSSLNGPAAAVVLVSYAAVGLLIPYYRHEQMTAKAQAADRQKAVNQQYLLESVRGMAVLRQLEVADARMKTGNEGFDHEATAFQQSQFGQLLKNMSATLVILVAWLFIVWLSGWTQPQPLQQALLAVFPLTFGPLLALTNLPASLLNGFAAARNLLNLLQEAPATSAAIDATQTLDQIATIQVDHVTFKYPSRDETVLRQVSLSLHAGEIVGFVGASGSGKSTLAKLIMGWYPLTQGRILIDGIDLTKIDPASLRAQVNYLPQTPVFFSESVRDNLTLHDSTITDAQIWTVLDQVKLTSRLRQAEKGLDENVVSGQLQFSSGEQQRLELARALLHPSSVLVLDEPTSNLDTENERLILDAIKAYYHGIVIMISHRAESAAYADRLYRFADHRVSAASTAPK
>NC_021721.1|WP_020751688.1|2330104_2330962_-|PRD-domain-containing-protein
MIIQNVLNNNAVVARHQQREVIVVERGIGFRAKKDAKMALRDSMKVYVPEDQAKLKIATATIASLPSAYLDLAAGIIQEAEKRLQTTFNSYLLIELADHVHFAVQRLHEKIVLHNKLLWEIQVAYTQEYEMGEWALHQIAAQLHEQLPEDEAGFIALKFVSNDLNHQQTVNSLAFTQTLASLTKIIFYNLGLDMNVKTPDYQRLVIHLKFFLQRMYAAATSPLSLKMENYDYVLLKHLQQDYARAYHCMEDVDRFMQQKLAIAIPKNEQIYLTMHIARLAKSLAE
>NC_021721.1|WP_003571191.1|2327814_2329653_-|PTS-glucose-transporter-subunit-IIA
MNESGLAQQLLNLIGGKQNINQVWHCATRLRFTLKDRAKVPKDKIEALDGVITVVEASGQFQVVIGNNVGDVYHEVVKLEPSLSEGETSGETAAQGKMTFKSAFNSLLTFISGVFTPFLGAMAGAGILKGLLSLAVVMGWLTAKSGAYQIWWAAADGIFYFLPIALAFTAAKQLKVNQFVSMAIAAAMVSPGIVALGAKATTIDFFGIPVVPANYTATVLPILLVVVVQKFLEPVFNKLWHESVRNIMAPLCLLVVIVPLTLIVVGPISATVSSWLATAIVSLNKSVPILAGLVLGGFWQVIVIFGVHWALVPVMMNNIAQNGTDLMMPILLPAVLSQAGAALAVFLRTRDAKMKSLAGSSTITALFGITEPTIYGITLKLKKPFYLACVAGAVGGMIVAISGAGANAAALASVLSLPTFIGKGFGLSVVGDVVAFALGTVLTYFFGGINAGAKTKTAPSANSELGEALAAPVKGVLVPLTGLADEVFASETMGKGVAIVPENGIVKAPVAGVIRLLYPTGHAIGIQSDKGSEILIHIGIDTVNLKGKHFQPLVAQGQHVEIGMPLVQFDHEAIEKEGYESTVMMIVTNSDQYQIATLGQGATDDRPVMTLA
>NC_021721.1|WP_003571189.1|2326194_2327643_-|family-1-glycosylhydrolase
MTYLNFPKNFLWGGATAANQLEGAYQEDGKGLSVADVLPQGKDRFAIVNRPDFNWTIDKSKYRYPNHQGIDHYHRFKEDIKLFSEMGFKCYRFSIAWSRIFPEGDEKTPNASGLKFYDEVIATCLKYDIEPVVTISHYEMPLHLVTKYGGWKNKRLIEFYKHFAETVLTRYFKQVKYWMTFNEINSAWAFPVMSQGLVANNGGNDKQTIFQAWHNQFVASAWAVKIGHALDPKLQVGCMLLYATTYSYDANPVNQLATLQQNQAFNFFCGDVQVRGEYPAYTDALMADNGFKFTDLNFSAEELTLLKNHPVDYIGFSYYMSAVVETVEKEHAEVGGNLLSGVKNPFLKASEWGWQIDPIGLRIALNQLYERYRKPLFIVENGLGAVDKPDADGKIKDDYRIDYLKQHIEQMGAAIHDGVDLMGYTPWGCIDLVSASSGQMSKRYGFIYVDLDDAGQGSLNRYKKQSFNWYQRVIASNGTDLG
>NC_021721.1|WP_003566920.1|2325501_2326068_-|TetR/AcrR-family-transcriptional-regulator
MDTREKLVATAASLFQKEGVRATGLAQILTVSGTPKGSLYYYFPNGKAQLIEAAITYAGQHILEHVQRDLDRYKAPDAALAGQLESMATEMQEKGHLGGNSISLIALETGDDPELQAACSAVFTQLETLYIKKLTSAGIPPDRAQPLGQFIQASIEGAIILAATKDNPDLLRQTADQLTRLIKLALAA
>NC_021721.1|WP_003571210.1|2339575_2340253_-|type-II-A-CRISPR-associated-protein-Csn2
MNLAYYPFQLITTKPSEVTVIDTASPKVLTDLIEALRNDLDKVVLSNDQLEPQEIRKASLWIGDPRLELDLDKLFQRLIYKRMELLIENQRLVELIDQSQQMAMDLIQDPFLSDLPVTVEPGGKLEQIMKYCNVHFDETVTTESTSKIEALIQTLTKLEEMKLVILTNVSHYLSARDFFAVTEQIGDTELQVVLIEFSKVNRRKYFEKCQYIYIDEDFVDSRELD
>NC_021721.1|WP_003586314.1|2340249_2340555_-|CRISPR-associated-endonuclease-Cas2
MRLMIMFDLPVLTSENRRNYRKFRKALINEGFLMMQYSIYVRVCSTKKSAEFLEHRIAAMKPPIGTVQTLMVTEAQYQAMHFLVGEAKQDIRNSADRTVII
>NC_021721.1|WP_003571214.1|2340532_2341438_-|type-II-CRISPR-associated-endonuclease-Cas1
MGWRSLIVTQHCKVTTKNRTLVVQTDSEVNNVPIEDINQVVFTTTRALLSADAITTLAEANAKVIFSGRDGQPVTETTNLYSDRRKADLVRLQVNWPKSLVENLWTKIVAAKVSIQAQVTKLCGYDNQSLLDDLDTLEINDHSNREATAARKYFKLIFGDDFSRSDICATNAALNYGYSILLSTTNRAIVSAGHITEIGMHHSSVANQYNLGSDLMEPFRPAIDYWVANQKFTDLTPNIKYGLIALLNLEVTFNGKKALLQNALDEHVENCLAYLDGKRNNCRIEVEFPNEVSSDAFNDHV
>NC_021721.1|WP_020751689.1|2341628_2345717_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MTKLGKPYGIGVDIGSNSIGFAAVDENSHLIRLKGKTVIGARLFEEGKAAAKRRAGRTTRRRLSRNRWRLSFLRDFFESHITPTDPNFFMRQKYSEISPKDKARYKYEKRLFNDRTDAEFYQQYSTMYHLRNRLMTDPSRADVREIYFAIHHILKSRGHFLTPGDAKDFNTNDVALDEIFPALQDAYAQVYPDLGITFDEDKENEFKTILLNEIATSIDTQRALVKLLLAEEDDKDILKQQKQVLTEFAKAVVGLKTKLNLALGTEVDSSEATAWNFSLGQLDDKWAGIESAMTDEGTEILDQIRDLYRARLLNGIVPTGKTLSQAKVDDYTQHHEDLQLFKAYLKQLEDDGTAKAIRQLYDRYIDGDDAAPFLRENFVKALTKDVTAHPNTKSPELLERLAQPDFMLKQRNKANGAIPVQMQQRELDQIIKNQAVYYDWLAAPNPVEKHRKSMPYQLDELLNFRIPYYVGPLVTAKEQKAAQGGVFAWMVRKDPEGNITPYNFDEKVDREASANTFIQRMKTTDTYLIGEDVLPKQSLLYQRYEVLNELNNVRVNNEKLSIEQKQQVIRELFERHNSVTIKQFAENLRAHGDYAHIPEIRGLADEKRFLSSLSTYRQLKSLLPEAIDDPAKQADIENIIAWSTVFEDAAIFKTKLKEISWLGSEAITKLSNIRYRGWGQFSRKFLNGLTLGNGHTIIQELLLSTNNLMQILTDETLQKKMTELNADKLKTANINDAIDNAYTSPSNKKALRQVLRVVDDIKRAADGQDPSWLYVETADGGGTPGKRTRARQHQLQEIYANAAHELIDTAVRGELEDKISDKADFNDRLVLYFMQGGRDIYTGAPLNIDQLSSYDIDHILPQSLIKDNSLDNRVLVHAIINREKNATFASTIYAQKMNATWRQWHEAGLISGRKLRNLQMRPDQIDKYASGFVARQLVETRQIIKLTEQIVAAQYPDTKIIAVKAGLSHQLREELEFPKNRDVNHYHHAFDAFLAARIGTYLLKRFPNLQAFFTYGKFTKADVKKLRGFNFIRDITHAEDKIVAKDTGEVVWDKQRDVDELDRIYNFKRMLITHEVRFETADLFKQTVYGARDSKEAGGSKQLIPKKKGYPVDIYGGYFRENTAYLAVVKVTKKTETIFKVVKIATSQVAALNKARSRSTAEELSVLTELLKPKFSKVGKNGKITDTPFEVVLPRVPREQLFYNAKYGFFMVNSDTMFHNFQEIWVSRSDQKILQQIRKAKIDYPNVDQDLDNLFHNLADQIVKYFDLYSIAGFKEKISQSQNTFNDLAVDDTDQSVGKITVINELLKGAQANGMTGSLKVLKISTPFGFTQDKSGVLTKDSSIIYQSPTGLFERSVRLTDL
>NC_021721.1|WP_003571219.1|2345865_2346660_-|hypothetical-protein
MEATKLAKRKQWPVPFSQTEPHFTFNNWLKFFSVVLFTYLLFYTRNPIGGFFNMSGTTFLNVANGWTRAVVVFGGVLYCAIIFAGAVWAAGWDGLSQLFASFRWRDIWYVFAYGVLYLIASTLGRILGDLVPIRFGVDFVNTLEAAQFGNLGAFSLISFRAFFMTLATQLTAVMIFLASQQLFSRLAIKHRRWALFLTYLLALAVTAVVTTTPLAPHVFVNIASGLVAQLPLYWVYRRSRNILVVTLSAFILMHVMIGLAVMLG
>NC_021721.1|WP_003571221.1|2346660_2347827_-|hypothetical-protein
MSRQNLMILIVDLVLIIIFIGGFGWGIGTVKRYQVEPNTSRTETNTDSLYSESRFEKTLQKFKRLDLMVRLGPVKDAKTFNYTPDEFNVKYSSQPIVSGLKATKTLNAETGEVEVCTTMTPQGVTVAGDYLLTTAYDHDGFHNSVMYIQDLKTGKLLNTVVLNGRPHVGGLTYDAKNDNIWICGRRNNAAEVFAIKLKTALTYNVDKKAKAVAYSQRAQLGNISRASFVTYYENALFVGFFNPTGKGNIQRYPLNDKGQVVGKSLTSSISNQFDVLTQSVLHQDILSKIQGMAFYGDYTILSQSYGGGNSTLYIFKTDPKKTIFRASDAIDTFDMPSHLEQISTHDGRMYMMFESAAYAYRHRSTNQLDRVLSMNLEGFVQLVLKEEK
>NC_021721.1|WP_003571223.1|2348050_2348425_+|YxeA-family-protein
MNMKKILIGIGIFIGLVILGGAGFYAWYTQSTPYYTQITTTGKKFDVIDDETGAARDIDYAYTQMAYDEKGHGTEVDFNGHKSRPLKMQAYLRLDYSTRRNQVISWEVVPKEKVPKAALAKLNR
>NC_021721.1|WP_020751690.1|2348618_2348942_+|DUF4870-domain-containing-protein
MTNEHKVLRGLSYISVIFAPILFPILVWIFTPQGSVTRDTAKHALWLHIIPTLLSIFVFMIIGGVGFFTNSINATSAVSLILLLVAMVVDIGMVVYNIYTGIKIITS
>NC_021721.1|WP_020751691.1|2349013_2350741_-|thiol-reductant-ABC-exporter-subunit-CydC
MHWLKNEHWVRPDLKRYRGLLVWSLILGVMTFVFAGALMFTSGFLIDKSATKPLFAAIYVTVVLTRAFGIGRPVFQYIERLTSHNWVLRITSHMRRKLYKVLETDAAFVSEHHQTGDILGLLADDIGHIQNLYLRMIFPTVVGAGLTVIATLLLGWFNWGFALWIMLLLLFQVLILPWWGLVVERFRKAEQKQLNHDAYVSLTDSVLGLSDWVITHREKDFMSQSLAAPKKLAASTVKSKRFQWRRDFVGQLLFVLIVISMLIWTNLEWTGNQASANWVGAFVLVVFPLDQAFSGIAQGVGEWPTYRDAIRHLNDLQPVTRQLPQQQAVPTQFKEMTLQHLSFQYTPKDPELITDIDLTVHSGEKIAILGPSGMGKTTLLQLVLGDLTPTTGNVLVDGQDVLTYQQHRTNLFAVLDQSPFLFNTSIVNNVRLGNEQASDADVAAALKAVKLDQLVAQLPNGINSSVEEAGFGFSSGERQRLSLARILLQDAPIVLLDEPTVGLDPITEQALLETMFTVLQGKTILWVTHHLQGVNQTDRVIFLEDGRLTMNDTPSHLAKNDERYQNLYALDAGLR
>NC_021721.1|WP_003571227.1|2350721_2352464_-|thiol-reductant-ABC-exporter-subunit-CydD
MIDKTLMRLSGMKRIMTMLAGFALVQAFVILLQGKFLAEGIVHSWNRQSLAGLWLPLGLFATAFVIRQLIVWVRNRIGARFAMTSSAWLQAQLLKHLYALGPAAVAKEGTGNLVTMALDGIPEAENYIELILNKILNMSIIPWVLVAYIWYENWLTGFTLLIMFPIIILFMVILGLAAQDKSESQYAGFQKMSNHFIDSLRGLKTLQLMGISRQYANNVYDVSEDYRKQTMGVLRIAMLSTFALDFFTTLSIAVVAVFLGIKLMDGAIPLYPAMVALILAPEYFMPIRDFGTDYHATLNGKNAMKAIWQVIDQPLPTDTNVLPAFSRWQAQDTVTINHLDFTYPNERAGIQDANLQFTGTEKVAIIGASGSGKSTLLNLIGGFLQPQKAAMTVRGTKVPHMTQAAWQDHLSYIPQDPYLFADTIAANIRFYRPDASDEDVKQAAEAAGLSHWIETLADGYATRIGEGGRGISGGQAQRIALARTLIDTNRSIWLFDEPTAHLDIETEAELKETLVPLFKNRLVIFATHRLHWLNQMDRVIVVDGGKIIAEGTPSELAAHSKPYQALVHEMRGEFNALVEK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021721_7	7.11\|2339486\|30\|NC_021721\|CRISPRCasFinder,CRT,PILER-CR	2339486-2339515	30	NZ_CP018229	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence	347900-347929	7	0.767
NC_021721_7	7.11\|2339486\|30\|NC_021721\|CRISPRCasFinder,CRT,PILER-CR	2339486-2339515	30	NZ_CP016290	Rhizobium leguminosarum strain Vaf10 plasmid unnamed3, complete sequence	472321-472350	7	0.767
NC_021721_7	7.1\|2338826\|30\|NC_021721\|CRISPRCasFinder,CRT	2338826-2338855	30	NZ_CP016024	Ralstonia insidiosa strain ATCC 49129 plasmid pRI-1, complete sequence	227967-227996	8	0.733
NC_021721_7	7.9\|2339354\|30\|NC_021721\|CRISPRCasFinder,CRT,PILER-CR	2339354-2339383	30	NZ_CP034227	Lactobacillus agilis strain La3 plasmid pLa3_2, complete sequence	3216-3245	8	0.733
NC_021721_7	7.11\|2339486\|30\|NC_021721\|CRISPRCasFinder,CRT,PILER-CR	2339486-2339515	30	NC_021920	Corynebacterium maris DSM 45190 plasmid pCmaris1, complete sequence	44607-44636	9	0.7
NC_021721_6	6.1\|2241069\|34\|NC_021721\|CRISPRCasFinder	2241069-2241102	34	NZ_LR214939	Mycoplasma salivarium strain NCTC10113 plasmid 2	717188-717221	10	0.706
NC_021721_7	7.9\|2339354\|30\|NC_021721\|CRISPRCasFinder,CRT,PILER-CR	2339354-2339383	30	MN693950	Marine virus AFVG_250M300, complete genome	1356-1385	10	0.667

1. spacer 7.11|2339486|30|NC_021721|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP018229 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ttagcttgaatgaggttcgcgaacgtttag	CRISPR spacer
ttagcctgaatgatgttcgcgaagtcgaag	Protospacer
*****.******* *********  .  **

2. spacer 7.11|2339486|30|NC_021721|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP016290 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.767

ttagcttgaatgaggttcgcgaacgtttag	CRISPR spacer
ttagcctgaatgatgttcgcgaagtcgaag	Protospacer
*****.******* *********  .  **

3. spacer 7.1|2338826|30|NC_021721|CRISPRCasFinder,CRT matches to NZ_CP016024 (Ralstonia insidiosa strain ATCC 49129 plasmid pRI-1, complete sequence) position: , mismatch: 8, identity: 0.733

cgcatatcactgagcatgtgcgagatcgtc	CRISPR spacer
cccataccactgagcatgtgcgaaaaacgg	Protospacer
* ****.****************.*

4. spacer 7.9|2339354|30|NC_021721|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP034227 (Lactobacillus agilis strain La3 plasmid pLa3_2, complete sequence) position: , mismatch: 8, identity: 0.733

aaggggcgtctttctttatatcatcggctt	CRISPR spacer
taggggcgtctttttttatatccgctcata	Protospacer
 ************.********  *   *

5. spacer 7.11|2339486|30|NC_021721|CRISPRCasFinder,CRT,PILER-CR matches to NC_021920 (Corynebacterium maris DSM 45190 plasmid pCmaris1, complete sequence) position: , mismatch: 9, identity: 0.7

ttagcttgaatgaggttcgcgaacgtttag	CRISPR spacer
gaagctcgagtgaggttcgcgaacgcggct	Protospacer
  ****.**.***************.

6. spacer 6.1|2241069|34|NC_021721|CRISPRCasFinder matches to NZ_LR214939 (Mycoplasma salivarium strain NCTC10113 plasmid 2) position: , mismatch: 10, identity: 0.706

tagaatttttaggcaattttagggcttttagccc	CRISPR spacer
tataatttttatgcaattttaggggattagttta	Protospacer
** ******** ************  ** . ..

7. spacer 7.9|2339354|30|NC_021721|CRISPRCasFinder,CRT,PILER-CR matches to MN693950 (Marine virus AFVG_250M300, complete genome) position: , mismatch: 10, identity: 0.667

aaggggcgtctttctttatatcatcggctt	CRISPR spacer
cttctttttctttctttttatcatcggctg	Protospacer
      . ********* ***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

17856 : 67798

Paenibacillus_phage(33.33%)

bacteriocin,holin,protease,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003568480.1\|17856_18714_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_003568482.1\|18793_18976_-	hypothetical protein	NA	NA	NA	NA
WP_003659010.1\|19026_19206_-	hypothetical protein	NA	NA	NA	NA
WP_003568484.1\|19694_20930_-	CHAP domain-containing protein	NA	NA	NA	NA
WP_020751361.1\|21133_23707_-	ABC transporter permease	NA	NA	NA	NA
WP_003568488.1\|23719_24421_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.9e-33	40.5
WP_003568490.1\|24700_25252_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_003568492.1\|25295_26102_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_003568494.1\|26106_26427_+	hypothetical protein	NA	NA	NA	NA
WP_003568543.1\|26652_27333_+	hypothetical protein	NA	NA	NA	NA
WP_003659016.1\|27265_27769_-	hypothetical protein	NA	NA	NA	NA
WP_003659018.1\|27788_29939_-	DUF1906 domain-containing protein	NA	NA	NA	NA
WP_003568499.1\|30283_31057_-	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_003568500.1\|31234_31840_+	DUF1211 domain-containing protein	NA	NA	NA	NA
WP_003568502.1\|32179_32404_+	hypothetical protein	NA	NA	NA	NA
WP_003568598.1\|32559_33237_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_003568507.1\|33401_34295_-	magnesium transporter CorA family protein	NA	NA	NA	NA
WP_003568509.1\|34343_34982_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_003568512.1\|35210_36587_+	Nramp family divalent metal transporter	NA	NA	NA	NA
WP_003562527.1\|36809_37154_-	hypothetical protein	NA	NA	NA	NA
WP_003562540.1\|37229_37589_-	hypothetical protein	NA	NA	NA	NA
WP_003562542.1\|37829_39272_+	C69 family dipeptidase	NA	NA	NA	NA
WP_003562544.1\|39466_40102_+	hypothetical protein	NA	NA	NA	NA
WP_003562546.1\|40151_40463_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_003562548.1\|40631_40820_+	hypothetical protein	NA	NA	NA	NA
WP_013245310.1\|40951_41563_-	hypothetical protein	NA	NA	NA	NA
WP_013245311.1\|41919_42393_+	hypothetical protein	NA	NA	NA	NA
WP_013245312.1\|42589_43123_+	hypothetical protein	NA	NA	NA	NA
WP_013245314.1\|43558_44608_-	nucleotidyl transferase AbiEii/AbiGii toxin family protein	NA	NA	NA	NA
WP_013245315.1\|44604_45342_-	hypothetical protein	NA	NA	NA	NA
WP_003562555.1\|45553_46264_+	AzlC family ABC transporter permease	NA	NA	NA	NA
WP_003577245.1\|46250_46580_+	AzlD domain-containing protein	NA	NA	NA	NA
WP_013245316.1\|47460_47676_-	hypothetical protein	NA	NA	NA	NA
WP_011673954.1\|48031_48907_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_003562571.1\|49252_49903_-	bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase	NA	NA	NA	NA
WP_003572914.1\|50300_50993_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_016386482.1\|51269_51626_+	hypothetical protein	NA	NA	NA	NA
WP_003572918.1\|51690_52011_+	hypothetical protein	NA	NA	NA	NA
WP_013245319.1\|52199_53075_-	Rgg/GadR/MutR family transcriptional regulator	A0A1X9I6E0	Streptococcus_phage	2.3e-11	27.3
WP_013245320.1\|53167_54760_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.3e-12	29.0
WP_013245321.1\|55105_56479_-	MFS transporter	NA	NA	NA	NA
WP_013245322.1\|56656_56980_-	hypothetical protein	NA	NA	NA	NA
WP_013245323.1\|57832_58588_+	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	3.9e-31	37.7
WP_123796487.1\|58563_59460_+\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	6.7e-30	36.3
WP_013245326.1\|59668_62986_-	MMPL family transporter	NA	NA	NA	NA
WP_003562586.1\|62982_63585_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_003572931.1\|63835_64096_-	hypothetical protein	NA	NA	NA	NA
WP_003562592.1\|64309_64972_-	ABC transporter permease	NA	NA	NA	NA
WP_003562594.1\|64971_65901_-	osmoprotectant ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_020751362.1\|65912_66542_-	ABC transporter permease	NA	NA	NA	NA
WP_012490780.1\|66544_67798_-\|holin	betaine/proline/choline family ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	1.5e-14	43.0

DBSCAN-SWA_2

596100 : 611861

Lactobacillus_phage(76.92%)

integrase

attL 585408:585421|attR 606862:606875

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
585408:585421	attL	NA	NA	NA	NA
WP_003577893.1\|596100_597030_+	cysteine synthase A	A0A1X9I5F1	Streptococcus_phage	5.9e-106	63.7
WP_013245460.1\|597219_597765_-	hypothetical protein	NA	NA	NA	NA
WP_020751437.1\|598085_599255_-\|integrase	site-specific integrase	Q6J1W6	Lactobacillus_phage	3.6e-217	97.4
WP_003573997.1\|599367_599628_-	hypothetical protein	B4XYT0	Lactobacillus_phage	2.5e-09	40.7
WP_003589914.1\|599717_600338_+	hypothetical protein	NA	NA	NA	NA
WP_003589917.1\|600321_600558_-	hypothetical protein	NA	NA	NA	NA
WP_003589919.1\|600750_601458_-	zinc ribbon domain-containing protein	NA	NA	NA	NA
WP_003572182.1\|601616_602039_-	ImmA/IrrE family metallo-endopeptidase	A0A0P0IJN5	Lactobacillus_phage	7.8e-21	39.1
WP_003572184.1\|602031_602385_-	helix-turn-helix transcriptional regulator	A0A141E1M3	Streptococcus_phage	7.7e-14	40.9
WP_003574003.1\|602628_602877_+	hypothetical protein	A0A0P0ID24	Lactobacillus_phage	2.7e-37	97.5
WP_003572187.1\|602918_603119_+	hypothetical protein	NA	NA	NA	NA
WP_003572188.1\|603089_603923_-	TIGR02391 family protein	A0A1S5SBU1	Streptococcus_phage	2.8e-46	37.8
WP_010493122.1\|603983_604742_+	ORF6C domain-containing protein	A0A1B0YEA7	Lactobacillus_phage	1.9e-41	49.4
WP_003572193.1\|604742_604922_+	hypothetical protein	NA	NA	NA	NA
WP_003604448.1\|604914_605166_-	DUF1883 domain-containing protein	NA	NA	NA	NA
WP_003572199.1\|605231_605588_+	DUF771 domain-containing protein	U5U4L9	Lactobacillus_phage	2.0e-62	98.3
WP_020751438.1\|605672_605876_+	hypothetical protein	NA	NA	NA	NA
WP_003586921.1\|605858_606404_-	hypothetical protein	NA	NA	NA	NA
WP_041168839.1\|606584_606899_+	hypothetical protein	NA	NA	NA	NA
606862:606875	attR	NA	NA	NA	NA
WP_003589923.1\|606891_607638_+	DnaD domain protein	A0A0N7IRA7	Lactobacillus_phage	5.8e-35	56.1
WP_003589925.1\|607652_608477_+	ATP-binding protein	A0A0P0I3L9	Lactobacillus_phage	6.6e-117	75.1
WP_003574016.1\|608476_608995_+	exonuclease domain-containing protein	NA	NA	NA	NA
WP_003564822.1\|609041_609464_+	hypothetical protein	NA	NA	NA	NA
WP_010493149.1\|610213_610501_+	hypothetical protein	Q8LTA8	Lactobacillus_phage	1.6e-38	76.8
WP_010493151.1\|610570_610903_+	hypothetical protein	NA	NA	NA	NA
WP_041168840.1\|611417_611861_+	autolysin regulatory protein arpU	A0A0P0IZI6	Lactobacillus_phage	8.0e-77	96.6

DBSCAN-SWA_3

616677 : 647766

Lactobacillus_phage(40.0%)

holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076626284.1\|616677_617010_+\|transposase	transposase	NA	NA	NA	NA
WP_003582147.1\|617039_617768_+	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	7.6e-32	40.1
WP_123796492.1\|617701_618643_+\|transposase	IS3 family transposase	Q6J1X2	Lactobacillus_phage	1.1e-17	28.7
WP_016364094.1\|618688_619552_+\|transposase	IS3 family transposase	Q6J1X2	Lactobacillus_phage	3.1e-24	30.5
WP_020751443.1\|620233_620512_+	hypothetical protein	NA	NA	NA	NA
WP_003572355.1\|620523_620790_+	hypothetical protein	NA	NA	NA	NA
WP_003572358.1\|620808_620985_+	hypothetical protein	NA	NA	NA	NA
WP_003572360.1\|620986_621214_+	hypothetical protein	NA	NA	NA	NA
WP_041168841.1\|621256_622498_+	hypothetical protein	NA	NA	NA	NA
WP_020751445.1\|622475_624026_+	DUF5011 domain-containing protein	NA	NA	NA	NA
WP_003589969.1\|624035_624455_+	single-stranded DNA-binding protein	NA	NA	NA	NA
WP_016388730.1\|624463_625042_+	hypothetical protein	NA	NA	NA	NA
WP_003605686.1\|625068_627525_+	type IV secretory system conjugative DNA transfer family protein	NA	NA	NA	NA
WP_020751446.1\|627521_629579_+	hypothetical protein	NA	NA	NA	NA
WP_003582234.1\|629584_629920_+	hypothetical protein	NA	NA	NA	NA
WP_003583424.1\|629903_630500_+	hypothetical protein	NA	NA	NA	NA
WP_003605684.1\|630480_632409_+	hypothetical protein	NA	NA	NA	NA
WP_020751447.1\|632410_633421_+	C40 family peptidase	A0A1X9SGZ2	Bradyrhizobium_phage	9.0e-15	38.3
WP_003605679.1\|633436_634081_+	hypothetical protein	NA	NA	NA	NA
WP_041168842.1\|634077_634485_+	thioredoxin family protein	NA	NA	NA	NA
WP_020751449.1\|634474_635296_+	hypothetical protein	NA	NA	NA	NA
WP_003587040.1\|635899_636079_+	hypothetical protein	NA	NA	NA	NA
WP_020751450.1\|636119_636374_+	hypothetical protein	NA	NA	NA	NA
WP_020751451.1\|636363_636801_+	hypothetical protein	NA	NA	NA	NA
WP_020751452.1\|636793_638038_+	hypothetical protein	NA	NA	NA	NA
WP_020751453.1\|638079_638325_+	hypothetical protein	NA	NA	NA	NA
WP_020751454.1\|638311_640852_+	DUF3991 domain-containing protein	NA	NA	NA	NA
WP_020751455.1\|641190_641313_+\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_003605664.1\|641449_641827_-	hypothetical protein	NA	NA	NA	NA
WP_003605663.1\|641829_641973_-	hypothetical protein	NA	NA	NA	NA
WP_020751456.1\|641965_642415_-	hypothetical protein	NA	NA	NA	NA
WP_003605660.1\|642428_642719_-	hypothetical protein	NA	NA	NA	NA
WP_003590008.1\|642728_643175_-	hypothetical protein	NA	NA	NA	NA
WP_003582052.1\|643677_644571_+	DNA/RNA non-specific endonuclease	NA	NA	NA	NA
WP_020751457.1\|644576_644936_+	hypothetical protein	NA	NA	NA	NA
WP_123796494.1\|644943_645730_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_003606341.1\|646180_647530_+	FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	1.7e-122	49.7
WP_071799104.1\|647571_647766_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_4

966284 : 1006800

Lactobacillus_phage(97.78%)

head,capsid,portal,tail,integrase,terminase,holin,tRNA,protease

attL 970524:970538|attR 979170:979184

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003564129.1\|966284_968696_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	68.3
WP_003564130.1\|968960_970604_+	polysaccharide biosynthesis protein	NA	NA	NA	NA
970524:970538	attL	NA	NA	NA	NA
WP_003564131.1\|970608_971319_+	pseudouridine synthase	NA	NA	NA	NA
WP_003564132.1\|971461_971677_+	zinc ribbon domain-containing protein	NA	NA	NA	NA
WP_003564133.1\|971793_972615_-	NAD(P)H-hydrate dehydratase	NA	NA	NA	NA
WP_003564134.1\|972611_973115_-	NUDIX hydrolase	NA	NA	NA	NA
WP_003593814.1\|973438_974578_-\|integrase	site-specific integrase	A0A0P0IXL3	Lactobacillus_phage	7.8e-217	98.9
WP_003598052.1\|974695_975763_-	Abi family protein	A0A0N7IRA5	Lactobacillus_phage	1.1e-207	100.0
WP_003598055.1\|975907_976339_-	hypothetical protein	A0A0P0IJV8	Lactobacillus_phage	6.8e-73	100.0
WP_012491228.1\|976408_976891_-	hypothetical protein	A0A0P0IZP3	Lactobacillus_phage	2.1e-83	100.0
WP_003598059.1\|976894_977188_-	hypothetical protein	A0A0P0HRW5	Lactobacillus_phage	5.7e-47	100.0
WP_020751498.1\|977371_978232_-	ImmA/IrrE family metallo-endopeptidase	A0A0P0IV64	Lactobacillus_phage	3.5e-145	91.6
WP_020751499.1\|978218_978578_-	helix-turn-helix transcriptional regulator	A0A0P0I3L3	Lactobacillus_phage	1.8e-34	64.7
WP_003578190.1\|978847_979045_+	hypothetical protein	A0A0P0IK60	Lactobacillus_phage	5.2e-28	100.0
WP_020751500.1\|979041_979839_+	ORF6N domain-containing protein	A0A0P0IDD0	Lactobacillus_phage	1.7e-56	59.8
979170:979184	attR	NA	NA	NA	NA
WP_003593164.1\|979846_980059_+	hypothetical protein	A0A0N7IRA6	Lactobacillus_phage	1.7e-29	98.6
WP_003657835.1\|980167_980392_+	DUF771 domain-containing protein	A0A0P0IQT9	Lactobacillus_phage	2.6e-39	100.0
WP_020751501.1\|980480_980693_+	hypothetical protein	A0A0P0IXL9	Lactobacillus_phage	5.2e-34	95.7
WP_020751502.1\|980702_981578_+	YqaJ viral recombinase family protein	A0A0P0IJW5	Lactobacillus_phage	4.7e-169	98.6
WP_016364601.1\|981580_981775_+	hypothetical protein	A0A0P0IZQ2	Lactobacillus_phage	5.5e-30	98.4
WP_020751503.1\|981774_982662_+	recombinase RecT	A0A0P0HRX2	Lactobacillus_phage	4.7e-161	98.6
WP_080652408.1\|982670_982916_+	helix-turn-helix transcriptional regulator	A0A0P0IV68	Lactobacillus_phage	2.5e-35	95.1
WP_041168849.1\|982920_983766_+	DnaD domain protein	A0A0N7IRA7	Lactobacillus_phage	2.8e-131	98.2
WP_020751505.1\|983803_984625_+	ATP-binding protein	A0A0P0I3L9	Lactobacillus_phage	3.0e-154	99.6
WP_025376211.1\|984691_985111_+	RusA family crossover junction endodeoxyribonuclease	A0A0P0IXM5	Lactobacillus_phage	3.5e-74	98.6
WP_019884715.1\|985115_985406_+	hypothetical protein	A0A0P0IJX1	Lactobacillus_phage	4.3e-39	98.9
WP_016364251.1\|985402_985726_+	hypothetical protein	A0A0N7IRA8	Lactobacillus_phage	2.8e-55	99.1
WP_041168850.1\|985804_986254_+	sigma-70 family RNA polymerase sigma factor	A0A0P0IZR0	Lactobacillus_phage	1.7e-74	93.3
WP_041168851.1\|986478_987093_+	hypothetical protein	NA	NA	NA	NA
WP_041168852.1\|987263_987644_+	HNH endonuclease	A0A0P0HRY0	Lactobacillus_phage	1.8e-69	96.8
WP_003582259.1\|987713_988088_+	hypothetical protein	A0A1B0YE76	Lactobacillus_phage	3.6e-62	100.0
WP_020751508.1\|988090_989821_+\|terminase	terminase large subunit	A0A1B0Y6B8	Lactobacillus_phage	0.0e+00	99.3
WP_020751509.1\|989839_991075_+\|portal	phage portal protein	A0A0P0IZM3	Lactobacillus_phage	8.4e-233	99.3
WP_020751510.1\|991052_991760_+\|protease	Clp protease ClpP	A0A1B0Y857	Lactobacillus_phage	3.9e-126	98.7
WP_016387127.1\|991764_992997_+\|capsid	phage major capsid protein	A0A1B0YA73	Lactobacillus_phage	1.4e-216	95.6
WP_016382022.1\|993070_993319_+	hypothetical protein	A0A0P0I3K0	Lactobacillus_phage	1.3e-36	96.3
WP_020751511.1\|993332_993659_+\|head,tail	phage gp6-like head-tail connector protein	A0A1B0Y2R7	Lactobacillus_phage	2.0e-53	99.1
WP_012491255.1\|993597_993936_+\|head	phage head closure protein	A0A0N7IRA3	Lactobacillus_phage	2.2e-58	100.0
WP_020751512.1\|993919_994249_+	hypothetical protein	A0A0P0IDB8	Lactobacillus_phage	4.9e-55	98.2
WP_016387125.1\|994238_994622_+	phage protein	A0A0P0IQS9	Lactobacillus_phage	2.2e-67	98.4
WP_020751513.1\|994633_995281_+	hypothetical protein	A0A0P0I7R6	Lactobacillus_phage	2.7e-113	94.9
WP_016387123.1\|995357_995723_+	hypothetical protein	A0A0P0IXK4	Lactobacillus_phage	1.0e-61	99.2
WP_020751514.1\|995803_995965_+	hypothetical protein	A0A1B0Y4R4	Lactobacillus_phage	1.7e-24	98.1
WP_020751515.1\|995984_999155_+\|tail	phage tail tape measure protein	A0A1B0YA78	Lactobacillus_phage	0.0e+00	98.4
WP_020751516.1\|999161_999857_+	hypothetical protein	A0A1B0Y2S2	Lactobacillus_phage	3.0e-126	97.8
WP_020751517.1\|999853_1004146_+\|tail	phage tail protein	A0A1B0Y2S0	Lactobacillus_phage	0.0e+00	75.1
WP_020751518.1\|1004174_1004600_+	DUF1617 family protein	A0A1B0Y2S1	Lactobacillus_phage	3.7e-71	98.6
WP_020751519.1\|1004602_1004872_+	hypothetical protein	A0A1B0Y3N0	Lactobacillus_phage	4.4e-38	97.7
WP_020751520.1\|1004917_1005211_+	hypothetical protein	A0A0P0IK41	Lactobacillus_phage	3.2e-42	88.7
WP_020751521.1\|1005200_1005617_+\|holin	phage holin	A0A0P0IDC6	Lactobacillus_phage	5.5e-43	98.9
WP_020751522.1\|1005627_1006800_+	LysM peptidoglycan-binding domain-containing protein	Q6J1W8	Lactobacillus_phage	4.6e-212	93.1

DBSCAN-SWA_5

1891086 : 1901589

Paenibacillus_phage(33.33%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003565997.1\|1891086_1892499_-	sugar porter family MFS transporter	O13311	Aichi_virus	8.4e-27	27.7
WP_003565999.1\|1892797_1894525_-	phosphoenolpyruvate--protein phosphotransferase	A0A1V0SGR7	Hokovirus	2.9e-21	30.8
WP_003566007.1\|1894524_1894791_-	phosphocarrier protein HPr	NA	NA	NA	NA
WP_003566008.1\|1894934_1895126_-	hypothetical protein	NA	NA	NA	NA
WP_020751588.1\|1895474_1897571_+\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	2.7e-114	39.6
WP_003570563.1\|1897691_1897985_+	DUF1827 family protein	NA	NA	NA	NA
WP_123796487.1\|1898271_1899168_-\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	6.7e-30	36.3
WP_013245323.1\|1899143_1899899_-	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	3.9e-31	37.7
WP_016386813.1\|1900014_1901589_-	peptide chain release factor 3	A0A1B0RXH7	Streptococcus_phage	3.4e-29	26.0

DBSCAN-SWA_6

2034904 : 2087898

Lactobacillus_phage(57.14%)

capsid,portal,tail,integrase,terminase,protease,head

attL 2046873:2046898|attR 2085241:2085266

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003566268.1\|2034904_2035666_+\|protease	matrixin family metalloprotease	G9I094	Helicoverpa_zea_nudivirus	1.7e-05	53.1
WP_003566270.1\|2035840_2036608_-	DeoR/GlpR transcriptional regulator	NA	NA	NA	NA
WP_003566272.1\|2036916_2038512_+	hypothetical protein	NA	NA	NA	NA
WP_003566275.1\|2039212_2039542_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_003566277.1\|2039918_2040563_+	DUF4767 domain-containing protein	NA	NA	NA	NA
WP_013245859.1\|2040888_2042382_-	protein kinase	M1HHG8	Acanthocystis_turfacea_Chlorella_virus	3.9e-14	30.0
WP_003566280.1\|2042750_2042963_-	hypothetical protein	NA	NA	NA	NA
WP_003566282.1\|2043262_2043739_+	hypothetical protein	NA	NA	NA	NA
WP_003566286.1\|2044200_2044425_+	hypothetical protein	NA	NA	NA	NA
WP_020751600.1\|2044862_2046278_-	group II intron reverse transcriptase domain-containing protein	NA	NA	NA	NA
WP_003566290.1\|2046423_2046576_+	hypothetical protein	NA	NA	NA	NA
2046873:2046898	attL	NA	NA	NA	NA
WP_020751601.1\|2047030_2048083_-	peptidoglycan recognition protein	A0A1B0Y4R9	Lactobacillus_phage	5.2e-199	95.1
WP_020751602.1\|2048084_2048357_-	hypothetical protein	Q9MCC7	Lactobacillus_phage	1.7e-40	94.4
WP_187289199.1\|2048346_2048589_-	hypothetical protein	U5U779	Lactobacillus_phage	1.5e-13	75.0
WP_041168860.1\|2048572_2048950_-	hypothetical protein	U5U712	Lactobacillus_phage	1.9e-58	88.7
WP_020751604.1\|2048962_2052982_-	CotH kinase family protein	Q597U3	Lactobacillus_virus	7.9e-38	47.1
WP_020751605.1\|2052950_2055053_-\|tail	phage tail protein	A0A2K9VBZ3	Lactobacillus_phage	4.1e-203	52.1
WP_020751606.1\|2055065_2055884_-\|tail	phage tail family protein	Q597U5	Lactobacillus_virus	4.2e-71	37.6
WP_020751607.1\|2055887_2058884_-\|tail	phage tail tape measure protein	A0A097BYC3	Leuconostoc_phage	2.9e-125	66.4
WP_123796509.1\|2058883_2059153_-	hypothetical protein	Q597U7	Lactobacillus_virus	6.1e-11	35.2
WP_020751609.1\|2059188_2059629_-	hypothetical protein	A0A2P0ZL56	Lactobacillus_phage	2.4e-25	51.4
WP_020751610.1\|2059692_2060322_-\|tail	phage major tail protein, TP901-1 family	G8FV40	Pediococcus_virus	7.1e-87	77.9
WP_020751611.1\|2060324_2060690_-	hypothetical protein	Q597V0	Lactobacillus_virus	6.7e-21	47.4
WP_020751612.1\|2060686_2061061_-	HK97 gp10 family phage protein	Q597V1	Lactobacillus_virus	1.6e-17	40.5
WP_041168861.1\|2061053_2061350_-	hypothetical protein	NA	NA	NA	NA
WP_020751614.1\|2061346_2061688_-\|head,tail	phage head-tail connector protein	Q597V3	Lactobacillus_virus	1.9e-33	59.3
WP_020751615.1\|2061684_2062563_-	hypothetical protein	A0A0P0IJL6	Lactobacillus_phage	1.2e-143	80.1
WP_020751616.1\|2062631_2063552_-\|capsid	phage capsid protein	A0A2P0ZL66	Lactobacillus_phage	1.3e-116	74.9
WP_020751617.1\|2063565_2064105_-	DUF4355 domain-containing protein	Q597V6	Lactobacillus_virus	2.4e-22	55.8
WP_020751618.1\|2064276_2064618_-	hypothetical protein	A0A1J1J9Q7	Escherichia_phage	5.0e-26	53.9
WP_020751619.1\|2064627_2065338_-	hypothetical protein	Q597V7	Lactobacillus_virus	5.3e-62	51.3
WP_020751620.1\|2065363_2066884_-\|portal	phage portal protein	Q597V8	Lactobacillus_virus	1.3e-179	64.3
WP_020751621.1\|2066885_2068178_-\|terminase	PBSX family phage terminase large subunit	Q597V9	Lactobacillus_virus	7.3e-179	69.6
WP_020751622.1\|2068167_2068719_-\|terminase	terminase small subunit	A0A0P0IUY4	Lactobacillus_phage	5.0e-60	92.4
WP_020751623.1\|2068718_2068856_-	hypothetical protein	NA	NA	NA	NA
WP_020751624.1\|2068865_2070014_-	hypothetical protein	A0A0P0I3G0	Lactobacillus_phage	2.9e-219	97.4
WP_016372095.1\|2070038_2070293_-	hypothetical protein	U5U404	Lactobacillus_phage	7.4e-43	95.2
WP_041168864.1\|2070651_2071095_-	autolysin regulatory protein arpU	A0A0P0IZI6	Lactobacillus_phage	1.1e-78	98.0
WP_020751625.1\|2071577_2071766_-	hypothetical protein	U5U7A2	Lactobacillus_phage	5.7e-08	62.3
WP_041168865.1\|2071762_2072050_-	hypothetical protein	Q8LTB3	Lactobacillus_phage	1.9e-42	88.4
WP_020751626.1\|2072046_2072418_-	hypothetical protein	Q6J1U7	Lactobacillus_phage	2.4e-42	72.7
WP_041168866.1\|2072414_2072807_-	hypothetical protein	C1KFE8	Lactobacillus_virus	4.4e-34	58.0
WP_020751627.1\|2072796_2073015_-	hypothetical protein	B4XYT5	Lactobacillus_phage	7.0e-34	95.8
WP_020751628.1\|2072998_2073310_-	hypothetical protein	NA	NA	NA	NA
WP_041168867.1\|2073306_2073513_-	hypothetical protein	B4XYT6	Lactobacillus_phage	1.4e-31	95.6
WP_020751629.1\|2073505_2074072_-	DUF1642 domain-containing protein	Q8LTB6	Lactobacillus_phage	7.2e-46	57.4
WP_020751630.1\|2074068_2074332_-	hypothetical protein	B4XYT2	Lactobacillus_phage	2.9e-42	97.7
WP_020751631.1\|2074344_2074953_-	hypothetical protein	NA	NA	NA	NA
WP_020751632.1\|2074963_2075887_-\|integrase	site-specific integrase	A8ATM2	Listeria_phage	1.1e-67	42.1
WP_020751633.1\|2075873_2076584_-	N-6 DNA methylase	A8YQM7	Lactobacillus_phage	2.0e-125	98.2
WP_020751634.1\|2076594_2076978_-	DUF1064 domain-containing protein	B4XYT1	Lactobacillus_phage	2.6e-63	93.7
WP_020751635.1\|2076980_2077430_-	hypothetical protein	Q6J1V3	Lactobacillus_phage	2.5e-65	87.9
WP_020751636.1\|2077445_2077931_-	single-stranded DNA-binding protein	U5U726	Lactobacillus_phage	1.6e-62	85.7
WP_020751637.1\|2077943_2078897_-	DnaD domain protein	A0A1B0Y2R2	Lactobacillus_phage	6.7e-121	87.7
WP_080652413.1\|2078912_2079713_-	PD-(D/E)XK nuclease-like domain-containing protein	A0A0P0IZH9	Lactobacillus_phage	4.0e-143	92.8
WP_020751639.1\|2079693_2080560_-	recombinase RecT	A0A0P0IJP1	Lactobacillus_phage	2.1e-153	96.5
WP_016371376.1\|2080572_2080980_-	hypothetical protein	A0A0P0IXE5	Lactobacillus_phage	4.0e-75	99.3
WP_019885644.1\|2081221_2081431_-	hypothetical protein	NA	NA	NA	NA
WP_004562014.1\|2081436_2081943_-	hypothetical protein	NA	NA	NA	NA
WP_016376224.1\|2082000_2082159_-	hypothetical protein	NA	NA	NA	NA
WP_020751641.1\|2082155_2082401_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_020751642.1\|2082530_2083214_+	LexA family transcriptional regulator	A6M973	Geobacillus_virus	4.5e-10	37.1
WP_041168868.1\|2083229_2083808_+	hypothetical protein	A0A1B0Y834	Lactobacillus_phage	3.1e-97	89.6
WP_020751644.1\|2083917_2085081_+\|integrase	tyrosine-type recombinase/integrase	A0A1X9I5C3	Streptococcus_phage	1.5e-45	31.0
WP_020751646.1\|2085245_2086799_-	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	1.8e-14	28.4
2085241:2085266	attR	NA	NA	NA	NA
WP_013245861.1\|2086971_2087898_-	type I pantothenate kinase	A0A1B1ISL9	uncultured_Mediterranean_phage	4.1e-30	32.9

DBSCAN-SWA_7

2387831 : 2465327

Lactobacillus_phage(77.59%)

capsid,portal,tail,integrase,terminase,holin,tRNA,protease,head

attL 2427651:2427666|attR 2471005:2471020

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003567053.1\|2387831_2388476_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_003571272.1\|2388556_2389615_+	LCP family protein	NA	NA	NA	NA
WP_003571273.1\|2389676_2390705_-	hypothetical protein	NA	NA	NA	NA
WP_003571274.1\|2390705_2391593_-	ABC transporter ATP-binding protein	NA	NA	NA	NA
WP_003567064.1\|2391589_2391955_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_003567066.1\|2392096_2392750_-	redox-sensing transcriptional repressor Rex	NA	NA	NA	NA
WP_003580616.1\|2392967_2394920_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	7.4e-58	30.8
WP_003567071.1\|2395193_2395529_-	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_003571278.1\|2395624_2396650_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	1.2e-59	41.6
WP_003567075.1\|2396683_2397217_-	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_003567077.1\|2397200_2397923_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_003571280.1\|2398238_2398844_-	hypothetical protein	NA	NA	NA	NA
WP_003567081.1\|2399074_2399593_-	folate family ECF transporter S component	NA	NA	NA	NA
WP_003567083.1\|2400064_2401045_+	asparaginase	NA	NA	NA	NA
WP_003567089.1\|2401140_2401884_-	acyl-ACP thioesterase	NA	NA	NA	NA
WP_003571286.1\|2401978_2402836_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	4.9e-70	53.0
WP_003567092.1\|2402837_2403176_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	4.6e-16	38.9
WP_003567093.1\|2403180_2404158_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	3.8e-26	28.1
WP_003567098.1\|2404157_2404487_-	cyclic-di-AMP receptor	NA	NA	NA	NA
WP_003567099.1\|2404521_2405166_-	dTMP kinase	M1PSC7	Streptococcus_phage	4.0e-53	53.1
WP_003571289.1\|2405759_2406023_-	YaaL family protein	NA	NA	NA	NA
WP_003567101.1\|2406022_2406622_-	recombination protein RecR	NA	NA	NA	NA
WP_003567105.1\|2406937_2407246_-	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_003571293.1\|2407262_2408960_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	3.0e-55	44.4
WP_003659520.1\|2409210_2409717_-	nucleoside deaminase	NA	NA	NA	NA
WP_003567111.1\|2409859_2410189_-	hypothetical protein	NA	NA	NA	NA
WP_003567112.1\|2410245_2410842_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_003571315.1\|2410946_2413556_-	bifunctional lysylphosphatidylglycerol flippase/synthetase MprF	NA	NA	NA	NA
WP_003571317.1\|2413833_2414247_+	hypothetical protein	NA	NA	NA	NA
WP_003567118.1\|2414396_2415329_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_003659525.1\|2415438_2421147_-	PII-type proteinase	NA	NA	NA	NA
WP_003571321.1\|2421436_2422336_+	peptidylprolyl isomerase	NA	NA	NA	NA
WP_025376236.1\|2422664_2422889_-	hypothetical protein	A0A0P0IUZ5	Lactobacillus_phage	1.8e-32	97.3
WP_020751694.1\|2422933_2424079_-	LysM peptidoglycan-binding domain-containing protein	Q6J1W8	Lactobacillus_phage	4.8e-89	53.1
WP_020751695.1\|2424089_2424536_-\|holin	phage holin	A8YQK6	Lactobacillus_phage	2.3e-63	91.9
WP_041168873.1\|2424528_2424738_-	hypothetical protein	A0A1B0YE97	Lactobacillus_phage	1.5e-12	100.0
WP_020751696.1\|2424718_2425105_-	hypothetical protein	U5U712	Lactobacillus_phage	2.1e-65	97.7
WP_020751697.1\|2425135_2425267_-	XkdX family protein	A0A0P0HRS7	Lactobacillus_phage	7.2e-18	93.0
WP_020751698.1\|2425259_2425550_-	hypothetical protein	Q3L0S1	Lactobacillus_rhamnosus_Lc-Nu-like_prophage	3.0e-24	56.2
WP_020751699.1\|2425551_2428479_-\|tail	phage tail protein	Q3L0S2	Lactobacillus_rhamnosus_Lc-Nu-like_prophage	0.0e+00	65.7
2427651:2427666	attL	NA	NA	NA	NA
WP_041168874.1\|2428479_2430471_-\|tail	phage tail family protein	Q7Y4B1	Lactobacillus_phage	1.2e-217	61.3
WP_020751701.1\|2430471_2433561_-	tape measure protein	A0A0P0IJD2	Lactobacillus_phage	9.4e-257	84.1
WP_003602749.1\|2433553_2433907_-	hypothetical protein	A0A0P0I7N9	Lactobacillus_phage	4.8e-56	97.4
WP_020751702.1\|2434011_2434344_-\|tail	tail assembly chaperone	A0A0P0IQQ6	Lactobacillus_phage	3.9e-52	99.1
WP_020751703.1\|2434419_2435010_-\|tail	phage tail protein	A0A0N7IR90	Lactobacillus_phage	4.9e-98	96.2
WP_003582636.1\|2435021_2435426_-	DUF3168 domain-containing protein	A0A0P0I3C8	Lactobacillus_phage	6.0e-71	99.3
WP_003602752.1\|2435426_2435792_-	hypothetical protein	A0A0P0IUZ3	Lactobacillus_phage	3.1e-58	97.5
WP_020751704.1\|2435788_2436091_-	hypothetical protein	A0A0P0HRN0	Lactobacillus_phage	5.9e-47	88.0
WP_020751705.1\|2436095_2436470_-\|head,tail	phage head-tail connector protein	A0A0P0IZF6	Lactobacillus_phage	4.7e-62	97.6
WP_041168875.1\|2436469_2437348_-	hypothetical protein	A0A0P0IJL6	Lactobacillus_phage	4.7e-145	80.5
WP_016385855.1\|2437416_2438463_-\|capsid	major capsid protein	A0A0P0IZJ7	Lactobacillus_phage	2.7e-187	98.2
WP_020751707.1\|2438476_2438791_-	hypothetical protein	A0A0P0IJQ8	Lactobacillus_phage	2.8e-47	93.3
WP_020751708.1\|2438803_2439442_-	DUF4355 domain-containing protein	A0A0P0ID10	Lactobacillus_phage	6.3e-91	99.1
WP_020751709.1\|2439559_2439925_-	hypothetical protein	A0A1Q1PVR6	Bacillus_phage	3.5e-17	54.5
WP_020751710.1\|2439941_2440382_-	hypothetical protein	NA	NA	NA	NA
WP_020751711.1\|2440393_2441380_-\|capsid	minor capsid protein	A0A0P0ID43	Lactobacillus_phage	8.9e-177	95.4
WP_041168876.1\|2441345_2442773_-\|portal	phage portal protein	A0A0P0IQQ3	Lactobacillus_phage	1.9e-257	93.9
WP_020751713.1\|2442777_2444031_-\|terminase	PBSX family phage terminase large subunit	A0A0P0I3B0	Lactobacillus_phage	6.1e-247	98.3
WP_020751714.1\|2444014_2444593_-\|terminase	terminase small subunit	A0A0P0IUY4	Lactobacillus_phage	5.1e-63	78.8
WP_020751715.1\|2444978_2446127_-	hypothetical protein	B4XYU0	Lactobacillus_phage	1.0e-216	95.3
WP_041168877.1\|2446408_2446858_-	hypothetical protein	NA	NA	NA	NA
WP_020751716.1\|2446854_2447829_-	hypothetical protein	NA	NA	NA	NA
WP_003582019.1\|2448454_2448883_-	hypothetical protein	NA	NA	NA	NA
WP_020751717.1\|2449234_2449708_-	hypothetical protein	A0A1I9KKE3	Lactobacillus_phage	6.5e-24	42.5
WP_020751718.1\|2449704_2450097_-	hypothetical protein	Q8LTB5	Lactobacillus_phage	3.4e-47	73.3
WP_003658047.1\|2450093_2450300_-	hypothetical protein	B4XYT6	Lactobacillus_phage	1.5e-33	98.5
WP_020751719.1\|2450292_2450505_-	hypothetical protein	NA	NA	NA	NA
WP_020751720.1\|2450494_2450707_-	hypothetical protein	NA	NA	NA	NA
WP_020751721.1\|2450696_2451089_-	hypothetical protein	A0A140HLR7	Bacillus_phage	2.8e-25	50.0
WP_020751722.1\|2451075_2451582_-	DUF1642 domain-containing protein	Q6J1U8	Lactobacillus_phage	8.1e-49	62.3
WP_020751723.1\|2451578_2451821_-	hypothetical protein	B4XYT2	Lactobacillus_phage	7.6e-13	51.7
WP_020751724.1\|2451832_2452297_-	hypothetical protein	A0A0P0IXF6	Lactobacillus_phage	1.7e-13	100.0
WP_016364507.1\|2452309_2452675_-	hypothetical protein	A0A2D1GPL1	Lactobacillus_phage	1.4e-66	100.0
WP_020751726.1\|2452671_2452926_-	hypothetical protein	U5U728	Lactobacillus_phage	6.7e-36	90.5
WP_020751727.1\|2452926_2453256_-	hypothetical protein	Q6J1V4	Lactobacillus_phage	1.1e-41	83.3
WP_020751728.1\|2453252_2454035_-	ATP-binding protein	Q6J1V5	Lactobacillus_phage	9.1e-132	92.3
WP_020751729.1\|2454021_2454873_-	DnaD domain protein	A0A1B0Y2R2	Lactobacillus_phage	2.4e-106	96.3
WP_080652417.1\|2454888_2455689_-	PD-(D/E)XK nuclease-like domain-containing protein	A0A0P0IZH9	Lactobacillus_phage	5.2e-143	92.1
WP_020751731.1\|2455669_2456533_-	recombinase RecT	A0A0P0IJP1	Lactobacillus_phage	3.8e-155	96.5
WP_020751732.1\|2456545_2456953_-	hypothetical protein	A0A0P0IXE5	Lactobacillus_phage	4.9e-73	96.3
WP_020751733.1\|2457183_2457510_-	hypothetical protein	NA	NA	NA	NA
WP_020751734.1\|2457500_2457974_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_020751735.1\|2458036_2458195_-	hypothetical protein	NA	NA	NA	NA
WP_020751736.1\|2458191_2458434_-	helix-turn-helix transcriptional regulator	A0A0P0HRP5	Lactobacillus_phage	8.6e-33	91.2
WP_080647126.1\|2458568_2458907_+	helix-turn-helix transcriptional regulator	A0A0P0IZG9	Lactobacillus_phage	1.0e-55	99.1
WP_020751737.1\|2458896_2459316_+	hypothetical protein	A0A0P0IJN5	Lactobacillus_phage	2.0e-77	99.3
WP_020751738.1\|2459379_2459985_+	DUF4352 domain-containing protein	A0A0P0IXE0	Lactobacillus_phage	2.9e-77	98.0
WP_020751740.1\|2460945_2461332_+	DUF2513 domain-containing protein	A0A0P0IV09	Lactobacillus_phage	2.3e-27	45.2
WP_041168878.1\|2461593_2462019_+	pyridoxamine 5'-phosphate oxidase family protein	A0A0P0I7K6	Lactobacillus_phage	3.1e-62	87.9
WP_041168879.1\|2462042_2462246_+	hypothetical protein	A0A0P0IQK8	Lactobacillus_phage	2.7e-27	85.1
WP_020751742.1\|2462353_2463928_+	SIR2 family protein	A0A1S5SA14	Streptococcus_phage	3.3e-24	25.0
WP_051132531.1\|2464112_2465327_+\|integrase	site-specific integrase	A0A1X9I5L3	Streptococcus_phage	8.5e-36	28.0
2471005:2471020	attR	NA	NA	NA	NA

DBSCAN-SWA_8

2499490 : 2564765

Bacillus_phage(18.18%)

bacteriocin,transposase,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003659543.1\|2499490_2500897_-\|tRNA	cysteine--tRNA ligase	A0A1V0SAQ2	Catovirus	5.7e-52	30.4
WP_013246002.1\|2501137_2502532_-	FAD-binding protein	NA	NA	NA	NA
WP_013246003.1\|2502657_2503245_-	hypothetical protein	NA	NA	NA	NA
WP_003567227.1\|2503244_2503436_-	hypothetical protein	NA	NA	NA	NA
WP_003576207.1\|2503911_2505405_-\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_013246004.1\|2505552_2506533_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_016386662.1\|2506648_2507320_-	ribose-5-phosphate isomerase A	NA	NA	NA	NA
WP_013246006.1\|2507503_2508334_+	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_013246007.1\|2508479_2509319_-\|protease	YhfC family intramembrane metalloprotease	NA	NA	NA	NA
WP_013246008.1\|2509331_2510348_-	membrane protein	NA	NA	NA	NA
WP_013246009.1\|2510354_2510729_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_013246010.1\|2510893_2512165_-	MucBP domain-containing protein	NA	NA	NA	NA
WP_003591638.1\|2512482_2513259_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_013246013.1\|2515355_2516471_-	PIN/TRAM domain-containing protein	NA	NA	NA	NA
WP_020751747.1\|2516492_2517857_-	DNA repair protein RadA	NA	NA	NA	NA
WP_003567256.1\|2517873_2518416_-	dUTP diphosphatase	J9PV85	Bacillus_phage	8.1e-39	48.6
WP_003595964.1\|2518636_2518927_+	N-acetyltransferase	NA	NA	NA	NA
WP_003567260.1\|2519043_2519421_-	DUF805 domain-containing protein	NA	NA	NA	NA
WP_003571381.1\|2519665_2520985_+	C1 family peptidase	R4TV59	Phaeocystis_globosa_virus	9.2e-60	34.5
WP_003576225.1\|2521343_2522690_+	C1 family peptidase	A0A2H4UTL8	Bodo_saltans_virus	6.9e-47	29.8
WP_003588720.1\|2522917_2524018_+	hypothetical protein	NA	NA	NA	NA
WP_016386658.1\|2524014_2525211_+	hypothetical protein	NA	NA	NA	NA
WP_003567269.1\|2525273_2526152_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.2e-12	26.4
WP_013246017.1\|2526313_2528368_+	potassium transporter Kup	M1IAJ4	Acanthocystis_turfacea_Chlorella_virus	1.6e-63	33.3
WP_013246018.1\|2528524_2531155_-	pyruvate, phosphate dikinase	H8YJB7	Vibrio_phage	1.1e-88	40.2
WP_020751524.1\|2531430_2532675_+\|transposase	ISL3 family transposase	Q6V7R1	Burkholderia_virus	1.1e-11	22.6
WP_003576237.1\|2532786_2533410_-	CBS domain-containing protein	NA	NA	NA	NA
WP_013246019.1\|2533909_2534581_-	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	NA	NA	NA	NA
WP_013246020.1\|2534678_2534918_-	hypothetical protein	NA	NA	NA	NA
WP_003599717.1\|2535092_2536214_+	low temperature requirement protein A	NA	NA	NA	NA
WP_003567280.1\|2536227_2536512_+	chromosome partitioning protein ParB	NA	NA	NA	NA
WP_003588738.1\|2536702_2537818_-	alpha-hydroxy-acid oxidizing protein	NA	NA	NA	NA
WP_003567284.1\|2538005_2538212_-	CsbD family protein	NA	NA	NA	NA
WP_003567286.1\|2538344_2538602_-	hypothetical protein	NA	NA	NA	NA
WP_003567288.1\|2538672_2538879_-	hypothetical protein	NA	NA	NA	NA
WP_013246021.1\|2539103_2539355_-	hypothetical protein	NA	NA	NA	NA
WP_013246023.1\|2539682_2540915_+	MFS transporter	NA	NA	NA	NA
WP_003576247.1\|2540993_2542250_-	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	7.3e-99	56.8
WP_003588744.1\|2542338_2543172_-	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	9.6e-47	42.4
WP_003567298.1\|2543488_2543683_-	hypothetical protein	NA	NA	NA	NA
WP_013246024.1\|2543936_2544473_-	hypothetical protein	NA	NA	NA	NA
WP_013246025.1\|2544661_2545885_-	hypothetical protein	NA	NA	NA	NA
WP_013246026.1\|2546473_2547301_-	class C sortase	NA	NA	NA	NA
WP_020751748.1\|2547307_2548867_-	SpaH/EbpB family LPXTG-anchored major pilin	NA	NA	NA	NA
WP_016386628.1\|2548863_2550186_-	hypothetical protein	NA	NA	NA	NA
WP_013246030.1\|2550187_2553193_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_003580832.1\|2553470_2554028_-	hypothetical protein	NA	NA	NA	NA
WP_013246031.1\|2554122_2555319_-	DUF2075 domain-containing protein	NA	NA	NA	NA
WP_003605954.1\|2555527_2556583_+	DUF2974 domain-containing protein	NA	NA	NA	NA
WP_013246032.1\|2556853_2557501_+	helix-turn-helix transcriptional regulator	A0A0S2MVM8	Bacillus_phage	1.7e-06	37.5
WP_003596042.1\|2557636_2557966_+	PadR family transcriptional regulator	NA	NA	NA	NA
WP_013246033.1\|2557962_2558751_+	hypothetical protein	NA	NA	NA	NA
WP_003567326.1\|2558803_2559592_+	hypothetical protein	NA	NA	NA	NA
WP_003567328.1\|2559636_2559915_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_003580845.1\|2559938_2560223_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_013246034.1\|2560415_2560712_-\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
WP_013246035.1\|2560816_2562172_-	threonine/serine exporter family protein	NA	NA	NA	NA
WP_013246036.1\|2562477_2562789_-	hypothetical protein	NA	NA	NA	NA
WP_013246037.1\|2562861_2563212_-	hypothetical protein	NA	NA	NA	NA
WP_013246038.1\|2563385_2564765_-\|bacteriocin	bacteriocin secretion accessory protein	NA	NA	NA	NA

DBSCAN-SWA_9

2746669 : 2754564

Paenibacillus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_123796487.1\|2746669_2747566_-\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	6.7e-30	36.3
WP_013245323.1\|2747541_2748297_-	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	3.9e-31	37.7
WP_003567716.1\|2748407_2748746_-	ASCH domain-containing protein	NA	NA	NA	NA
WP_003567718.1\|2749041_2750016_-	ribose-phosphate diphosphokinase	A0A2K9L8D8	Tupanvirus	6.8e-44	36.4
WP_003567720.1\|2750113_2751502_-	bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU	A0A2K9L821	Tupanvirus	2.8e-27	33.6
WP_003567722.1\|2751641_2752835_-	RDD family protein	NA	NA	NA	NA
WP_003567724.1\|2752831_2753680_-	pur operon repressor	A0A1V0SKE5	Klosneuvirus	1.1e-05	26.4
WP_003567726.1\|2753913_2754564_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	2.8e-17	33.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_021722

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_021722_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021722_1

447-592

Orphan

Consensus_repeat	Method
CGGGAAACCGAAAATCGGTCGCCCGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_021722_1

>merge|NC_021722|1|447-592|CRISPRCasFinder
CGGGAAACCGAAAATCGGTCGCCCGCAAGAGACCGTTCAAACTACCGAAAACAGCGGGAAACCGAAAATCGGTCGCCCGCGACATAAGAACTCAAGTGAAGCCGGACCCCTTGAAAATAGCGGGAAACCGAAAATCGGTCACGATC

>NC_021722|1|1|447-592|CRISPRCasFinder
CGGGAAACCGAAAATCGGTCGCCCGC	AAGAGACCGTTCAAACTACCGAAAACAG
CGGGAAACCGAAAATCGGTCGCCCGC	GACATAAGAACTCAAGTGAAGCCGGACCCCTTGAAAATAG
CGGGAAACCGAAAATCGGTCACGATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021722.1\|WP_003596668.1\|2289_2517_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375153
NC_021722.1\|WP_020751793.1\|14132_14858_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|374625
NC_021722.1\|WP_016372389.1\|3283_3502_+\|hypothetical-protein	unknown	unknown	unknown
NC_021722.1\|WP_002816607.1\|9414_10098_+\|IS6-family-transposase	unknown	unknown	gnl\|CDD\|225853
NC_021722.1\|WP_020751789.1\|5785_7051_+\|C39-family-peptidase	unknown	unknown	gnl\|CDD\|379241
NC_021722.1\|WP_020751792.1\|11443_14140_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238119
NC_021722.1\|WP_016370447.1\|3039_3276_+\|hypothetical-protein	unknown	unknown	unknown
NC_021722.1\|WP_020751786.1\|1060_1798_+\|hypothetical-protein	unknown	unknown	unknown
NC_021722.1\|WP_020751787.1\|3494_3725_+\|hypothetical-protein	unknown	unknown	unknown
NC_021722.1\|WP_016367338.1\|3711_3987_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021722.1\|WP_003596668.1\|2289_2517_+\|hypothetical-protein	gnl\|CDD\|375153	pfam17362, pXO2-34, Family of unknown function. This is a family of unknown function found in Bacilli.	1.21466e-12
NC_021722.1\|WP_020751793.1\|14132_14858_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|374625	pfam16555, GramPos_pilinD1, Gram-positive pilin subunit D1, N-terminal. GramPos_pilinD1 is the first subunit domain of Gram-positive pilins from Strep.pneumoniae. There are three major pilin subunits that form the polymeric backbone of the pilin from S. pneumoniae, constructed of three Ig-like, CnaB, domains along with a crucial N-terminal domain, D1. The three IG-like domains are stabilized by internal Lys-Asn isopeptdie bonds, but this N-terminal domain makes few contact with the rest of the molecule due to the different orientation of its G beta-strand. Strand G of D1 also carries the YPKN motif that provides the essential Lys residue for the sortase-mediated intermolecular linkages along the pilus shaft. Gram-positive pili are formed from a single chain of covalently linked subunit proteins (pilins), usually comprising an adhesin at the distal tip, a major pilin that forms the polymer shaft and a minor pilin that mediates cell wall anchoring at the base.	2.24137e-15
NC_021722.1\|WP_002816607.1\|9414_10098_+\|IS6-family-transposase	gnl\|CDD\|225853	COG3316, COG3316, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.4394e-66
NC_021722.1\|WP_020751789.1\|5785_7051_+\|C39-family-peptidase	gnl\|CDD\|379241	pfam13529, Peptidase_C39_2, Peptidase_C39 like family.	2.16045e-13
NC_021722.1\|WP_020751792.1\|11443_14140_+\|VWA-domain-containing-protein	gnl\|CDD\|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	7.27595e-15

>NC_021722.1|WP_020751786.1|1060_1798_+|hypothetical-protein
MSSKEFDQRKRKVFPEELALKNLKELTEAERAGLHLLMIQTSDPYEREDILAEAQKTANQRAEEAKKHSYAAIKKRLTQEQTKTDTELNAFTQHRNRHVKVLGKVTMMAGYFMTPKRIRPTKYYWLVPDDLVIPDRPLGRVAHVRGKDGQLHDVMVLYVTKQKQRQLQDGRVVPDQFMIEFTSQYASSVQVKQGQRTERQRQKDYRGPFDSAQQKHNRVRKVIRRHHRVREELANLEKSKKKDKN
>NC_021722.1|WP_003596668.1|2289_2517_+|hypothetical-protein
MAILARSGVVRQAFCVRTFDRRVLINHANGSFYDRDHASLEAIEQLYPKIRSVYNSDHTMIAKRKHPQAALYKLS
>NC_021722.1|WP_016370447.1|3039_3276_+|hypothetical-protein
MKQQKKSQQYEVVTEFVNMTKLGQITTVEDYFKYRHAHMRDLSLQERHLLMTWLNRSKTVRLKRKRHQDMVHSEIEMR
>NC_021722.1|WP_016372389.1|3283_3502_+|hypothetical-protein
MKAIDKLLVFMQQHGLTSIDYATYDRARRLYDHDPVRQREWIEILAESKTDQRIVVRHGVLGSSVKAVSLGA
>NC_021722.1|WP_020751787.1|3494_3725_+|hypothetical-protein
MLKQTKVPFVNGVGKTLPHLEKGVRYTFVDHGYYMTALRPGETEEIKPELPEQEWEYRRHHPIKEWQIGGNHHAIL
>NC_021722.1|WP_016367338.1|3711_3987_+|hypothetical-protein
MRFYEFDTDHHDYYALIAADTPEEAKRIYQNEIDDAIDDLMPHEVSLDQAAEILLEADDLADFHDELVEKEKLVLKGEDDARTIVIDSNLL
>NC_021722.1|WP_020751789.1|5785_7051_+|C39-family-peptidase
MKMTKLVSMSTIAATVLSGLVLAASPVQAATWTARKPAKIQITKGQKVYTIQWGDTLWAISQRTNITVAKLAQLNGVANPSFIMTGATLTLDWSQAGTATATMTAPDGTVTGQSTIQQQDKVDPAKSVGTTVSGSKVTQAAGQTASSATNEQSSTTTPSEPASSVASSSQATNSDTSSSSKESGSTNANSSSSANTSSSAVTPSSSSSSQESSSSKPSTPSSSSAASSSADQPSTPSAPSEPVVTQKVLGVPFVSQGNTMLCEGSSLLEGLLYKGYTTQNLSQFVQSMPLSADNNPYDGYSGEWRHNVDGTYQGMMATPVVQWAAKYGSKAVNISGQGTAGIKREITKGNSVVAWITYDYEAPEFKQMSWGRAVWNGHVVNVDGFKDGAYHVVDPVFGARWINAGTFENAFNVTGMAVAVR
>NC_021722.1|WP_002816607.1|9414_10098_+|IS6-family-transposase
MNHFKGRHFQKDIILVAVGYYFRFSLSYRDIVELLRDRGITVHHTTVMRWVHHYGPIFKALWRRHQTAHAKSWRIDETYIRVKGRWAYLYRAIDSNGLTMDFELRKHRDYTASYHFLKRLLTTNGRPDRLVTDQYRATLKAVKHLIKQDYLSKSAHQCSKYRNNLIEQDHRFIKRHRVRSASFQSIRTASATLSGVEIVHAIRKRTRRELSLIGFSVVDELEALLAA
>NC_021722.1|WP_020751792.1|11443_14140_+|VWA-domain-containing-protein
MTRMTAKVARTGHLFAVLLILMSMLTGLVTSGSSVVTATANIRPTYKTNANGTYPENSWQVTGQQNVINQRGGDQVSGWDNNTTWDGDATNTTNSYLKFGDPNNPDYQIRKYAKETNTPGLYDVYLNVKGNTQQNVKPVDIVLVVDMSGSMEFNRYNTNRAGAVRTGVKNFLTSIQNAGLGNYVNVGLIGFSSPGYIGGESGYISVKLGKAGNASQQQAINGALSPRFQGGTYTQIGLRQGSAMLNADTSGNKKMMILLTDGVPTFSNKVINSEWINGTLYGTNFGSSRDEPSDTAQLRWPYTDSSGNTIYDTWPATLGEAKKAKDSGNEVHALGIQLADDGHYMTKEKIRQNMQLITNSPDLYKDADSADAVEAYLNNQAKDIIKNFNTVTDGTITDPIGTQFQYANNQATVTSVGKQTVPASELPSAAIQDGQLTVKHMNLGQDQEVQIHYQVRIKTEDAGFKPDFWYQMNGETLLTPKAGAAAVDFGIPSGRAPATTVYVQKQWRQLSNQSLPDTLNVTVQRKVADGSLDPNWQQTLVLKKADNWKASFTAPAYNNQGQSFSYVVKSEDASGIDLSSFISSQNMDQQTATLTLTNQQYGFQFQKKTTDGTDLSTDQLKAMQFNLTQYSDNSFQQVSKTNAITSTDLQALAPGYYGIQEAAAPTGYQLDGTTYLFQLTSEGQWQYHGTKDNVTSGSVINGQQTLNPVGDKSDDFTVTGDHQQILTLTKYDEPKPSMTLRVIKQDNQSQYLAGAAFTLQPSAGEAETITSSATSEGQAFATKLVADGTYTMSETKAPDGYQSNPAKIAIQVATTGKEATVTIDGEALKPGESKNGYTLAIDGSTITLQAINQPLAILPHTGGQGYQRLLGIALGLISAAFLLLLVVLIKRRVVKQHD
>NC_021722.1|WP_020751793.1|14132_14858_+|LPXTG-cell-wall-anchor-domain-containing-protein
MTKSFRPLVILTFCLALLVSLATTTLQQTQAATVPTTVDVVLHKLLFKDTLPTQQANNGTTKPDFSQADVPLNGVTFTVYDVTADFWQLVSKNGGAIEAAQTTLSQDSYQPASSSLIAQVVTAGQGEAYFGDLPLRQGQHAAVYLFKETAAPKNIEASQNLVVVMSSNLQHGNQSRIDLFPKNKMVSRHTDVPKKVPKKTRQLLPQTGDTVAAWLSMLGLIIFATVLAFNIKNQKINKWER

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Identity
NC_021722_1	1.1\|473\|28\|NC_021722\|CRISPRCasFinder	473-500	28	NZ_CP029537	Lactobacillus paracasei strain LC355 plasmid unnamed1, complete sequence	34627-34654	1.0
NC_021722_1	1.1\|473\|28\|NC_021722\|CRISPRCasFinder	473-500	28	NZ_CP017263	Lactobacillus paracasei strain FAM18149 plasmid pFAM18149.22, complete sequence	24575-24602	1.0
NC_021722_1	1.1\|473\|28\|NC_021722\|CRISPRCasFinder	473-500	28	NC_021722	Lactobacillus paracasei strain LOCK919 plasmid pLOCK919, complete sequence	473-500	1.0
NC_021722_1	1.1\|473\|28\|NC_021722\|CRISPRCasFinder	473-500	28	NZ_CP035564	Lactobacillus paracasei strain SRCM103299 plasmid unnamed1	65056-65083	1.0
NC_021722_1	1.2\|527\|40\|NC_021722\|CRISPRCasFinder	527-566	40	NC_021722	Lactobacillus paracasei strain LOCK919 plasmid pLOCK919, complete sequence	527-566	1.0
NC_021722_1	1.2\|527\|40\|NC_021722\|CRISPRCasFinder	527-566	40	NZ_CP035564	Lactobacillus paracasei strain SRCM103299 plasmid unnamed1	65110-65149	1.0
NC_021722_1	1.2\|527\|40\|NC_021722\|CRISPRCasFinder	527-566	40	NZ_CP029537	Lactobacillus paracasei strain LC355 plasmid unnamed1, complete sequence	34561-34600	1.0
NC_021722_1	1.2\|527\|40\|NC_021722\|CRISPRCasFinder	527-566	40	NZ_CP017263	Lactobacillus paracasei strain FAM18149 plasmid pFAM18149.22, complete sequence	24509-24548	1.0

1. spacer 1.1|473|28|NC_021722|CRISPRCasFinder matches to NZ_CP029537 (Lactobacillus paracasei strain LC355 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

aagagaccgttcaaactaccgaaaacag	CRISPR spacer
aagagaccgttcaaactaccgaaaacag	Protospacer
****************************

2. spacer 1.1|473|28|NC_021722|CRISPRCasFinder matches to NZ_CP017263 (Lactobacillus paracasei strain FAM18149 plasmid pFAM18149.22, complete sequence) position: , mismatch: 0, identity: 1.0

aagagaccgttcaaactaccgaaaacag	CRISPR spacer
aagagaccgttcaaactaccgaaaacag	Protospacer
****************************

3. spacer 1.1|473|28|NC_021722|CRISPRCasFinder matches to NC_021722 (Lactobacillus paracasei strain LOCK919 plasmid pLOCK919, complete sequence) position: , mismatch: 0, identity: 1.0

aagagaccgttcaaactaccgaaaacag	CRISPR spacer
aagagaccgttcaaactaccgaaaacag	Protospacer
****************************

4. spacer 1.1|473|28|NC_021722|CRISPRCasFinder matches to NZ_CP035564 (Lactobacillus paracasei strain SRCM103299 plasmid unnamed1) position: , mismatch: 0, identity: 1.0

aagagaccgttcaaactaccgaaaacag	CRISPR spacer
aagagaccgttcaaactaccgaaaacag	Protospacer
****************************

5. spacer 1.2|527|40|NC_021722|CRISPRCasFinder matches to NC_021722 (Lactobacillus paracasei strain LOCK919 plasmid pLOCK919, complete sequence) position: , mismatch: 0, identity: 1.0

gacataagaactcaagtgaagccggaccccttgaaaatag	CRISPR spacer
gacataagaactcaagtgaagccggaccccttgaaaatag	Protospacer
****************************************

6. spacer 1.2|527|40|NC_021722|CRISPRCasFinder matches to NZ_CP035564 (Lactobacillus paracasei strain SRCM103299 plasmid unnamed1) position: , mismatch: 0, identity: 1.0

gacataagaactcaagtgaagccggaccccttgaaaatag	CRISPR spacer
gacataagaactcaagtgaagccggaccccttgaaaatag	Protospacer
****************************************

7. spacer 1.2|527|40|NC_021722|CRISPRCasFinder matches to NZ_CP029537 (Lactobacillus paracasei strain LC355 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

gacataagaactcaagtgaagccggaccccttgaaaatag	CRISPR spacer
gacataagaactcaagtgaagccggaccccttgaaaatag	Protospacer
****************************************

8. spacer 1.2|527|40|NC_021722|CRISPRCasFinder matches to NZ_CP017263 (Lactobacillus paracasei strain FAM18149 plasmid pFAM18149.22, complete sequence) position: , mismatch: 0, identity: 1.0

gacataagaactcaagtgaagccggaccccttgaaaatag	CRISPR spacer
gacataagaactcaagtgaagccggaccccttgaaaatag	Protospacer
****************************************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_021721

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_021722

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection