CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021486	Streptococcus agalactiae ILRI005, complete genome	2 crisprs	cas3,cas5,cas8c,cas7,cas4,cas1,cas2,DinG,csn2,csm6,DEDDh	2	7	8	3

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_021486_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021486_1

475530-475895

TypeI

I-C

Consensus_repeat	Method
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	PILER-CR
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	CRT

5 spacers

cas2,cas1,cas4,cas7,cas8c,cas5

The CRISPR arrays of NC_021486_1

>merge|NC_021486|1|475530-475895|PILER-CR,CRISPRCasFinder,CRT
GTCGCACCCTTTGCGGGTGCGTGGATTGAAATTATACAAACTTCTGCGTTATCTTCGTCATAATTAGTCGCACCCTTTGCGGGTGCGTGGATTGAAATAAGTGGGTTAGTACAACTGAATGGGATGAAAAACGTCGCACCCTTTGCGGGTGCGTGGATTGAAATCTAAAGGTGTCTTATGGGATTCGAACCCATAGTGGCGTCGCACCCTTTGCGGGTGCGTGGATTGAAATATGCATTGATGTAACTTTCTATATTATTGACAACTGTCGCACCCTTTGCGGGTGCGTGGATTGAAATTCCCAGTCCAATGTTTTATTAGCCATCTCAGCCTCGTCGCACCCTTTGCGGGTGTGTAGTTTCAACT

>NC_021486|1|1|475530-475828|PILER-CR
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	TATACAAACTTCTGCGTTATCTTCGTCATAATTA
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	AAGTGGGTTAGTACAACTGAATGGGATGAAAAAC
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	CTAAAGGTGTCTTATGGGATTCGAACCCATAGTGGC
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	ATGCATTGATGTAACTTTCTATATTATTGACAACT
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT

>NC_021486|1|1|475530-475895|CRISPRCasFinder
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	TATACAAACTTCTGCGTTATCTTCGTCATAATTA
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	AAGTGGGTTAGTACAACTGAATGGGATGAAAAAC
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	CTAAAGGTGTCTTATGGGATTCGAACCCATAGTGGC
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	ATGCATTGATGTAACTTTCTATATTATTGACAACT
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	TCCCAGTCCAATGTTTTATTAGCCATCTCAGCCTC
GTCGCACCCTTTGCGGGTGTGTAGTTTCAACT

>NC_021486|1|1|475530-475895|CRT
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	TATACAAACTTCTGCGTTATCTTCGTCATAATTA
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	AAGTGGGTTAGTACAACTGAATGGGATGAAAAAC
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	CTAAAGGTGTCTTATGGGATTCGAACCCATAGTGGC
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	ATGCATTGATGTAACTTTCTATATTATTGACAACT
GTCGCACCCTTTGCGGGTGCGTGGATTGAAAT	TCCCAGTCCAATGTTTTATTAGCCATCTCAGCCTC
GTCGCACCCTTTGCGGGTGTGTAGTTTCAACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021486.1\|WP_016480399.1\|472535_473384_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|226175
NC_021486.1\|WP_016480391.1\|460752_461334_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NC_021486.1\|WP_000049317.1\|476031_476991_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NC_021486.1\|WP_016480403.1\|478214_479279_+\|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|225197
NC_021486.1\|WP_016480393.1\|462693_465342_+\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582
NC_021486.1\|WP_017647061.1\|480430_480880_-\|thiol-reductase-thioredoxin	unknown	unknown	gnl\|CDD\|273542
NC_021486.1\|WP_000384889.1\|481561_481852_+\|hypothetical-protein	unknown	unknown	unknown
NC_021486.1\|WP_000748011.1\|479393_480386_+\|aspartate--ammonia-ligase	unknown	unknown	gnl\|CDD\|225304
NC_021486.1\|WP_016480400.1\|474053_475079_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NC_021486.1\|WP_016480397.1\|469904_470633_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|273847
NC_021486.1\|WP_016480407.1\|481848_482334_+\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|173914
NC_021486.1\|WP_000262367.1\|473385_474057_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|224385
NC_021486.1\|WP_016480402.1\|477151_478054_+\|magnesium-transporter-CorA-family-protein	unknown	unknown	gnl\|CDD\|213361
NC_021486.1\|WP_016480409.1\|483471_484806_+\|bifunctional-metallophosphatase/5'-nucleotidase	unknown	unknown	gnl\|CDD\|277323
NC_021486.1\|WP_016480394.1\|465559_466339_-\|hypothetical-protein	unknown	unknown	unknown
NC_021486.1\|WP_016480406.1\|481010_481550_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	unknown	unknown	gnl\|CDD\|367574
NC_021486.1\|WP_016480398.1\|470632_472531_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	gnl\|CDD\|187773
NC_021486.1\|WP_041165654.1\|461338_462670_+\|hypothetical-protein	unknown	unknown	unknown
NC_021486.1\|WP_016480408.1\|482323_483397_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|226011
NC_021486.1\|WP_041165655.1\|475089_475383_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG1343_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|187856

Protein	Function_ID	Function_description	E-value
NC_021486.1\|WP_016480399.1\|472535_473384_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|226175	COG3649, COG3649, CRISPR system related protein [Defense mechanisms].	1.099e-154
NC_021486.1\|WP_016480391.1\|460752_461334_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	3.05582e-37
NC_021486.1\|WP_000049317.1\|476031_476991_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	2.99134e-57
NC_021486.1\|WP_016480403.1\|478214_479279_+\|MmcQ/YjbR-family-DNA-binding-protein	gnl\|CDD\|225197	COG2315, MmcQ, Uncharacterized protein conserved in bacteria [Function unknown].	2.34539e-19
NC_021486.1\|WP_016480393.1\|462693_465342_+\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
NC_021486.1\|WP_017647061.1\|480430_480880_-\|thiol-reductase-thioredoxin	gnl\|CDD\|273542	TIGR01295, Pediocin_PA-1_biosynthesis_protein_PedC, bacteriocin transport accessory protein, putative. This model describes a small family of proteins believed to aid in the export of various class II bacteriocins, which are ribosomally-synthesized, non-lantibiotic bacterial peptide antibiotics. Members of this family are found in operons for pediocin PA-1 from Pediococcus acidilactici and brochocin-C from Brochothrix campestris.	3.67155e-08
NC_021486.1\|WP_000748011.1\|479393_480386_+\|aspartate--ammonia-ligase	gnl\|CDD\|225304	COG2502, AsnA, Asparagine synthetase A [Amino acid transport and metabolism].	0
NC_021486.1\|WP_016480400.1\|474053_475079_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	5.97584e-174
NC_021486.1\|WP_016480397.1\|469904_470633_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|273847	TIGR01876, cas_Cas5d, CRISPR-associated protein Cas5, subtype I-C/DVULG. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum. This family belongs to a set of several Cas protein families, one each for a number of different CRISPR/Cas subtypes, that share a region of N-terminal sequence similarity modeled by TIGR02593. This family represents the Dvulg subtype of CRISPR/Cas locus.	9.24626e-112
NC_021486.1\|WP_016480407.1\|481848_482334_+\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|173914	cd02163, PPAT, Phosphopantetheine adenylyltransferase. Phosphopantetheine adenylyltransferase (PPAT). PPAT is an essential enzyme in bacteria, responsible for catalyzing the rate-limiting step in coenzyme A (CoA) biosynthesis. The dinucleotide-binding fold of PPAT is homologous to class I aminoacyl-tRNA synthetases. CoA has been shown to inhibit PPAT and competes with ATP, PhP, and dPCoA. PPAT is a homohexamer in E. coli.	7.91713e-77
NC_021486.1\|WP_000262367.1\|473385_474057_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|224385	COG1468, COG1468, CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms].	2.63288e-30
NC_021486.1\|WP_016480402.1\|477151_478054_+\|magnesium-transporter-CorA-family-protein	gnl\|CDD\|213361	cd12827, EcCorA_ZntB-like_u2, uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family. A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.	9.31433e-70
NC_021486.1\|WP_016480406.1\|481010_481550_+\|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD	gnl\|CDD\|367574	pfam03602, Cons_hypoth95, Conserved hypothetical protein 95.	4.64843e-83
NC_021486.1\|WP_016480398.1\|470632_472531_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187773	cd09642, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-C subtype; also known as Csd1 family.	0
NC_021486.1\|WP_041165655.1\|475089_475383_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	4.05251e-31
NC_021486.1\|WP_016480408.1\|482323_483397_+\|PDZ-domain-containing-protein	gnl\|CDD\|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	8.89207e-136
NC_021486.1\|WP_016480409.1\|483471_484806_+\|bifunctional-metallophosphatase/5'-nucleotidase	gnl\|CDD\|277323	cd00845, MPP_UshA_N_like, Escherichia coli UshA-like family, N-terminal metallophosphatase domain. This family includes the bacterial enzyme UshA, and related enzymes including SoxB, CpdB, YhcR, and CD73. All members have a similar domain architecture which includes an N-terminal metallophosphatase domain and a C-terminal nucleotidase domain. The N-terminal metallophosphatase domain belongs to a large superfamily of distantly related metallophosphatases (MPPs) that includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.59376e-60

>NC_021486.1|WP_041165655.1|475089_475383_+|CRISPR-associated-endonuclease-Cas2
MMVLVTYDVNTKTVAGRRRLRHVAKLCVDYGQRVQNSVFECSVTPAEFVEIKNELLTIIDQKSDSIRFYLLGKNWQNRVETIGKNDSYDPDIGILLL
>NC_021486.1|WP_016480400.1|474053_475079_+|type-I-C-CRISPR-associated-endonuclease-Cas1
MKKLLNTLYLTQDNFYLTRERDNIVIKQEGKIVHRFPYRIIDGIICFSYLGASPSLIELCTEKQINLSFHTPQGRLCGRFVGSTNGNVLLRREHYRLADHALSIEYAKRFILAKVSNSRKYLIRFKRDHRDRIDIQLFEDINTELMWALELIQSAPDKETLLGIEGQAANQYFRAFNELVLTDKDTFRFNGRTRRPPQDCINALMSFGYSLLTYECQSALEAVGLDSYVGFYHTDRPGRASLALDLVEEFRSYIVDRFVFSLVNKGQLNKRHFDIKENSSVILTEKGRTIFIESWQKRKHTVVEHPFTKEKVKLMLLPYVQAQLLSKAIRGDLESYPPFLI
>NC_021486.1|WP_000262367.1|473385_474057_+|CRISPR-associated-protein-Cas4
MVYAEDDYLMLSGIQHFQFCKRQWALIHIEQQWLDNEATAHGQILHTKADNPYIKEKRKDFLVSRAMHVSSKILGLYGILDVVEFYKDENGFSLKGKRGKWLPCIVEYKRGKPKKDRRDIVQLVAQTICLEETFGCYIEKGCLYYHSVNQKKTIEITEELRQEVLDLAEQMHFYYDNKIIGKAEYFKNCPLCSLVDICKPRLSKKTRNVDNYIRQSLVNEDSL
>NC_021486.1|WP_016480399.1|472535_473384_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MLEHKIDFIVTFEVKEANANGDPLNGNMPRTDAKGYGVMSDVSIKRKIRNRLQDMGKPIFVQANERIEDDFRSLEKRFSQHFTAKTPDKEIEEKANALWFDVRAFGQVFTYLKKSIGVRGPISNSMAKSLEPIVISSLQITRSTNGMEAKNNSGRSSDTMGTKHFVDYGIYVLKGSINAYFAEKTGFSQEDAEAIKEVLVSLFENDASSARPEGSMRVREVFWFTHSSKLGNVSSARVFDLLEYNQSIEEKSTYDAYQIHLNQEKLAKYEAKGLTVKILEGL
>NC_021486.1|WP_016480398.1|470632_472531_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MDFFTSLLKTYEKAELADLVDHQKRNNEPVLLPIYHTSLKSNGKNIISVKLDKDGQFHKAEFMTDKQMIIFPVTADSVARSGSNPAPHPLVDKFAYYSAEMGQSQYDSFHKQLNNWIDYCEEGDVKRFLTIVQQFILKPEFLTLILDSLIGPDYQNNQLKVTFCDATEKEKLIDLSACFLEFSIDQFQGFKNESVSTFKTLHQSYISFVEANRENLGICNISGREEQLTDKHRGLMGNAKIISVSNKREAYKGRFREREDVFSVGYETSEKIHLMIKYLLENKNTSTWLGSSQYLINWFSDDLTNDSRLDIVSPIFDDGLEEDDEEEDLPSVIALATEENKRIGKSFIKGQKLFANDATYYIAILNKTSNGRIALKYFRQIQASQLLTNLDKWQEKYSWESRSKSGKSRLRTPAFHDILNVSYGVDRDRFLELDNDNFKSDQVQKLVTSLIDGKPMPQSIVKKLGNNVKERHRYRKHWYQVEQVCLAILHKQNGEEFSPMLDHTNQNRSYLFGRLLAIFELIETLRYSLEGNGSDRITNAERYWTAYTGQPTKLMMLLENKIKPYEETLKLNRRGSWKKLEKEKEEILELLNPLLETETMEKSLDYRFIFGYYAEKNYYYPKQNTEVTESEK
>NC_021486.1|WP_016480397.1|469904_470633_+|type-I-C-CRISPR-associated-protein-Cas5
MYRSRDFYVRVSGQRALFTNPATKGGSERASYSVPTRQALNGIVDAIYYKPTFTNIVTEVKVINQIQTELQGVRALLHDYSADLSYVSYLSDVVYLIKFHFIWNEDRKDLNSDRLPAKHEAIMERSIRKGGRRDVFLGTRESVGLVDDISQEEYEAAVSYYNGVNIDLGIMFHSFAYPKDKKTPLKSYFTKTVMENGVITFNTQSDCDIVNTLSSYAFKVPEEIKSVNDEYMEYDAMEKGEN
>NC_021486.1|WP_016480394.1|465559_466339_-|hypothetical-protein
MLNSDFIISKSLANYIHHRRLEVGVSSTDLAEISNMSKSDWESFEKNGGAIPLKSKDIILDLLFLERFPKEKECDFIDKLFEEAKENKLWPGKIYQTMGLTPALSFIAGCEILSDDINNDLEELSKLPKESHLGQLDTSLLLSLLPQQFITKYDYEFVYKLSKVLAQYTSRNKVGSSYTAHNVIEEICLYLIAKESILYFESLDENSHLQLKELLDYNDEWPFDIFDDMDSYTFLYTDIYIEEDSPYHFKNWFVPQFYL
>NC_021486.1|WP_016480393.1|462693_465342_+|valine--tRNA-ligase
MTELSPKYNPAEVEAGRYQTWLDQDVFKPSGDIEAKPYSIVIPPPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLREQGISRYDLGREKFLDKVWEWKDEYAATIKSQWGKMGLSVDYSRERFTLDEGLSKAVRKVFVDLYNKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVATTRPETMFGDVAVAVNPEDPRYKDLIGQNVILPIINKPIPIVADEHADPEFGTGVVKITPAHDPNDFAVGQRHNLPQVNVMNDDGTMNELADEFNGMDRFEARKAVVAKLESLGNLVKIEKMTHSVGHSERTGVVVEPRLSTQWFVKMDQLAKNAIANQDTEDKVEFYPPRFNDTFMSWMENVHDWVISRQLWWGHQIPAWYNVNGEMYVGEDAPEGDGWTQDEDVLDTWFSSALWPFSTMGWPDTEAADFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFSNVLIHGLIRDEEGRKMSKSLGNGIDPMDVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDASWNFINKIWNISRYILMNNEGLTLDQARENVKKVVNSQVGNVTDRWILHNLNETVGKVTENFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEDEKVITRSVLLYTLDQILRLLHPIMPFVTEEIFGQYAEGSIVLASYPKVNATFENQTAHKGVESLKDLIRSVRNSRAEVNVAPSKPITILVKTSDSELESFFKDNSNYIKRFTNPETLEISSAIATPELAMSSVITGAEIYLPLADLLNVEEELTRLDKELAKWQKELDMVGKKLGNERFLANAKPEVVQKEKDKQADYQAKYDATQERIVEMQKLVK
>NC_021486.1|WP_041165654.1|461338_462670_+|hypothetical-protein
MDYLFMDEKGPQNSFKITTPFDKQNKLSYANDNMHSYVTNVIQVEEPSYRLIEQEYNQIVETYLSSRVQLRQSLKNKDKELKGLDLLKSNFDYGIASMKDKEVQFYTSLFLMLNQYDVGNLLFMISKMSIITSSRLTNFFYFLDEETEFSPYIAKYVLTKYAEIEASKKVVEALLNKTLPTRPLLKLIKEDLNRIINNNQGNMRMKQQLAIYQQLIAAMDRIINDHKIKLLEPELKLSFDWSKVKWAFDLWMTEQNSPDKNSECTLFLDEGIPSNIFTELNINKIEEDCDSRDYVGLQITDMIVVLIGKLVSQMTANTRYDFNKPSQRVLLDKEYFNLNEQQYKLILELNKFLIDRDTKYHFVNDAYFDESLSLQVYIGYISSFDNFEEYKSLSSSEHNEIYLRNVINFANLKYKDGVENILQAKFLYGSLKKSVEIRQSRPL
>NC_021486.1|WP_016480391.1|460752_461334_+|GNAT-family-N-acetyltransferase
MQILEDFDGKALPKLETDRLILRQRTVEDVPAMFDYVCLEEVAYPAGLSPIASLEDEYDYFENRYYQNLEKAKLPSGYGITVKGSDRIIGSCDFNHRHEDDVFEIGYMLHPDYWGHGYMTEAVAALIEVGFTLLNLHKIEIRCYDYNKQSRRVAEKLGFTLEATIRDRKDNQGNRCVNLIYGLLRSEWEKKVE
>NC_021486.1|WP_000049317.1|476031_476991_+|Gfo/Idh/MocA-family-oxidoreductase
MSKVRYGVVSTAKVAPRFIEGVRLAGNGEVVAVSSRTLESAQAFANKYHLPKAYDKLEDMLADESIDVIYVATINQDHYKVAKAALLAGKHVLVEKPFTLTYDQANELFALAESCNLFLMEAQKSVFIPMTQVIKKLLASGEIGEVISISSTTAYPNIDHVTWFRELELGGGTVHFMAPYALSYLQYLFDATITHASGTATFPKGQSDSQSKLLLQLSNGVLVDIFLTTRLNLPHEMIIYGTEGRLIIPHFWKTTHAKLVRNDTSARTIQVDMVSDFEKEAYHVSQMILEGQRVSHIMTPQLTLSGVKIIEDLYRSWGK
>NC_021486.1|WP_016480402.1|477151_478054_+|magnesium-transporter-CorA-family-protein
MFSSDFGFEIINVDDLSLQEERFLPSELLAYARDENESSFVRDIEGRLTLVYQLLDTQGHVDDVRHVPRVIPVTLFLKEDGLFVLANHKNINLVKKALNRVEKVDSPKHLLLSLVTAFSKQYFDVLDTISEERDKLINDLRKRPNKSNLARLANLQSGTVHLMMGTKQNFEMLTDLQNIEQDKENTRNEKMQLQDAIIEARQLSNMCSLNSQVFQELSSSYNNVLSNNLNDNVTTLTIISIGISIIAMVTSFYGMNVKLPFDSVDAVWVLIILITTIITIMLSIVMYIYVHKEDNHPKHK
>NC_021486.1|WP_016480403.1|478214_479279_+|MmcQ/YjbR-family-DNA-binding-protein
MSIESDFFRKKRFIFSSLEEFGFIKSDQEYIYCQTFMDNDFKAIITISLDGKIAGKVIDLALEEEYLPLRAANYNGSFVGEVRSAYMAILGDISDSCCKDLLFTKDQSNRLAEKIAKTFEDSVDYPFAKHPQYASYRVSGKWYALLFPLKMGKLENAPAQLSEDEVEVLNIKVNPQDMEILLQKEGIYPSYHMSKKTWVSIVLDNTLSDIEIFKLVSDSRKLVSPNKKSNSEPEFWIIPANPKFYDIDKEFAEHQLIDWTQKGKIAVGDYVFIYITAPIRALRYVCQVIERDLKTSTYLGARDVKAYMRLKLIRQFEDSTYPVAFLAEHGVKTVRGPRRMTKELRQVMAKTILE
>NC_021486.1|WP_000748011.1|479393_480386_+|aspartate--ammonia-ligase
MKKSFIHQQQEISFVKNTFTQYLIDKLEIVEVQGPILSQVGDGMQDNLSGIEHPVSVKVLNIPEAEFEVVHSLAKWKRHTLARFGFNEGEGLFVHMKALRPDEDSLDPTHSVYVDQWDWEKVIPDGRRNLDYLKETVEKIYKAIRLTELAVEARFDIESILPKRITFIHTEELVEKYPDLSPKERENAIAKEYGAVFLIGIGGELADGKPHDGRAPDYDDWTTPSENGFKGLNGDILVWNEQLGTAFELSSMGIRVDEDALKRQVVLTGDEDRLEFEWHKTLLRGFFPLTIGGGIGQSRLAMFLLRKKHIGEVQSSVWPKEVRDTFENIL
>NC_021486.1|WP_017647061.1|480430_480880_-|thiol-reductase-thioredoxin
MIKKLLLSLIAILCLTTLKSNLSSADTMTISQQQYQHMITNSDLIAITDKALVSKSQQSEATIFIGRPTCQYCRAFLPKLLKSQATLHSKIYYLDSQKYKGERLKSFFKKHHITTVPNLAHYQRGKMTKYLVQGSQATPQQIQTFLSQK
>NC_021486.1|WP_016480406.1|481010_481550_+|16S-rRNA-(guanine(966)-N(2))-methyltransferase-RsmD
MRVVAGTFGGRPLKTLDGKTTRPTTDKVKGAIFNMIGPFFEGGRVLDLFSGSGSLAIEAISRGMDQAVLVEKDRRAQVVIQENIAMTKSPEQFQLLKMEANRALEQLTGHFDLVLLDPPYAKEEIVKQIQIMDSKGLLGDDIMIVCETDKSVDLPEEIASFGIWKQKIYGISKVTVYVR
>NC_021486.1|WP_000384889.1|481561_481852_+|hypothetical-protein
MDYKLVMIILILVILIYLLLRLHYLEELLKHYHFKNDEGVCSLSRTKNPLYLLMAMITFLPNLINWIANGFEAIDIVRLIPVVVFLWLYYCGDDDE
>NC_021486.1|WP_016480407.1|481848_482334_+|pantetheine-phosphate-adenylyltransferase
MTKKALFTGSFDPVTNGHLDIIERASYLFDHVYIGLFHNLEKQGYFSIECRKKMLEEAIRQFKNVSVLVAQDRLAVDLAREVGAKYFVRGLRNSQDFDYEANLEFFNKQLADDIETVYLSTSPSLSPISSSRIRELIHFKASVKPFVPKSVVREVEKMSEE
>NC_021486.1|WP_016480408.1|482323_483397_+|PDZ-domain-containing-protein
MKNKDPKRKHKSLLGLFKWWIIGFAFLLLVLASLVVRLPYYLEMPGGAYDIRSVLKVNKKADKAKGSYNFVAVSVSQATPAQVLYAWLTPFTELSSKEETTGGFSNDDYLRINQFYMETSQNESVYQALKLANKQVSLTYKGVYVLNLAKNSTFKDRLHLADTVTGVNGKSFKNSSQLIKYVAALHLGDKVKVQYTSQGKKKESVGKVIKLSNGKNGIGIGLTDHTEVSSDVPVDFNTEGVGGPSAGLMFTLAIYDQLVKEDLRKGRKIAGTGTIEQNGHVGDIGGAGLKVVSAAKKGMDIFFVPNNPIDKNAKKGKTKVQTNYQEAKAAAKRLGTKMKIVPVQNVQQAIDYLKKTK
>NC_021486.1|WP_016480409.1|483471_484806_+|bifunctional-metallophosphatase/5'-nucleotidase
MTELIRILHLNDLHSHFENFPKVKRFFHDNQAQPIETISLDLGDNIDKSHPLTEASSGKANVQLMNELGIELATIGNNEGVGLSKKDLDQVYKDSDFTVIVGNLKDNIIEPSWAKPYIIYETQQGTKIAFLAYTFPYYKTYEPNGWTIEDPIDCLKCHLQINEIKKANCRILMSHLGIRFDTRIAQEFSEIDLIIGAHTHHLFEEGELINGTYLAAAGKYGRFVGSIDITFDNHTLKDILISTYDTKQLTGYPSDSDWAKEIESEGKEQLRKESLISFPAPLSLEESYQLVMDAMLFYAGADVAIINSGLIVQPFEKDFSRKNLHESLPHQMRLAKLTVSSQELLEIYETIYQQGQFLAQQKIHGMGFRGKCFGEVLYSGFDYKNGKIVYNEKDIDAKEEVILVIVDQYYFASYFECLKTKKVDLLFPELLRDVVADYLINMTL

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Crispr_ID: NC_021486_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021486_2

933638-933871

TypeII-A

II-A

Consensus_repeat	Method
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CRISPRCasFinder
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CRT

3 spacers

csn2,cas2,cas1

The CRISPR arrays of NC_021486_2

>merge|NC_021486|2|933638-933871|CRISPRCasFinder,CRT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACCTAGTCAAATCTTGCAAGAGATTAGTGACAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGGTCTTTTAGTTTTTTGATGTCATCAACATGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTAAGAAGTATAAAGAGCTTCTACGCACCATGTTTTAGAGCTGCGCTGTTTCGAATGGTACCAAAAC

>NC_021486|2|2|933638-933871|CRISPRCasFinder
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CTAGTCAAATCTTGCAAGAGATTAGTGACA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGTCTTTTAGTTTTTTGATGTCATCAACAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TAAGAAGTATAAAGAGCTTCTACGCACCAT
GTTTTAGAGCTGCGCTGTTTCGAATGGTACCAAAAC

>NC_021486|2|2|933638-933871|CRT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CTAGTCAAATCTTGCAAGAGATTAGTGACA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGTCTTTTAGTTTTTTGATGTCATCAACAT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TAAGAAGTATAAAGAGCTTCTACGCACCAT
GTTTTAGAGCTGCGCTGTTTCGAATGGTACCAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021486.1\|WP_016480712.1\|932871_933537_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd09758_csn2_CAS-II-A	gnl\|CDD\|213408
NC_021486.1\|WP_016480716.1\|939864_940524_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NC_021486.1\|WP_016480707.1\|923523_923904_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131381
NC_021486.1\|WP_001904401.1\|932543_932885_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NC_021486.1\|WP_000665410.1\|940996_941431_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|234692
NC_021486.1\|WP_000323544.1\|925868_926639_+\|TIGR01457-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|319832
NC_021486.1\|WP_016480718.1\|941582_944375_+\|cation-transporting-P-type-ATPase	unknown	unknown	gnl\|CDD\|223550
NC_021486.1\|WP_000523795.1\|925130_925868_+\|acyl-ACP-thioesterase	unknown	unknown	gnl\|CDD\|366738
NC_021486.1\|WP_016480717.1\|940532_940997_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_021486.1\|WP_001019133.1\|935051_936884_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NC_021486.1\|WP_000146569.1\|946817_947456_-\|CatB-related-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100040
NC_021486.1\|WP_016480713.1\|934499_934916_+\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NC_021486.1\|WP_041165678.1\|923996_925127_+\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NC_021486.1\|WP_016480709.1\|926628_927285_+\|TIGR01906-family-membrane-protein	unknown	unknown	gnl\|CDD\|226884
NC_021486.1\|WP_016480711.1\|931677_932547_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NC_021486.1\|WP_041165679.1\|933928_934189_+\|hypothetical-protein	unknown	unknown	unknown
NC_021486.1\|WP_144312747.1\|944809_945915_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NC_021486.1\|WP_016480715.1\|937131_939765_+\|pneumococcal-type-histidine-triad-protein	unknown	unknown	gnl\|CDD\|380193
NC_021486.1\|WP_000159230.1\|923127_923499_+\|YbgA-family-protein	unknown	unknown	gnl\|CDD\|377982
NC_021486.1\|WP_000521427.1\|921652_923005_+\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670

Protein	Function_ID	Function_description	E-value
NC_021486.1\|WP_016480712.1\|932871_933537_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	3.14581e-121
NC_021486.1\|WP_016480716.1\|939864_940524_+\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	2.11513e-33
NC_021486.1\|WP_016480707.1\|923523_923904_+\|hypothetical-protein	gnl\|CDD\|131381	TIGR02328, TIGR02328, conserved hypothetical protein. Members of this protein are found in a small number of taxonomically well separated species, yet are strongly conserved, suggesting lateral gene transfer. Members are found in Treponema denticola, Clostridium acetobutylicum, and several of the Firmicutes. The function of this protein is unknown. [Hypothetical proteins, Conserved].	1.16052e-79
NC_021486.1\|WP_001904401.1\|932543_932885_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.59955e-51
NC_021486.1\|WP_000665410.1\|940996_941431_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|234692	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB.	6.40832e-86
NC_021486.1\|WP_000323544.1\|925868_926639_+\|TIGR01457-family-HAD-type-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.19143e-132
NC_021486.1\|WP_016480718.1\|941582_944375_+\|cation-transporting-P-type-ATPase	gnl\|CDD\|223550	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NC_021486.1\|WP_000523795.1\|925130_925868_+\|acyl-ACP-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	3.68196e-111
NC_021486.1\|WP_016480717.1\|940532_940997_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.16368e-19
NC_021486.1\|WP_001019133.1\|935051_936884_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NC_021486.1\|WP_000146569.1\|946817_947456_-\|CatB-related-O-acetyltransferase	gnl\|CDD\|100040	cd03349, LbH_XAT, Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. Members of this class of enzymes include Enterococcus faecium streptogramin A acetyltransferase and Pseudomonas aeruginosa chloramphenicol acetyltransferase. They contain repeated copies of a six-residue hexapeptide repeat sequence motif (X-[STAV]-X-[LIV]-[GAED]-X) and adopt a left-handed parallel beta helix (LbH) structure. The active enzyme is a trimer with CoA and substrate binding sites at the interface of two separate LbH subunits. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients.	3.59126e-72
NC_021486.1\|WP_041165678.1\|923996_925127_+\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NC_021486.1\|WP_016480709.1\|926628_927285_+\|TIGR01906-family-membrane-protein	gnl\|CDD\|226884	COG4478, COG4478, Predicted membrane protein [Function unknown].	3.13514e-51
NC_021486.1\|WP_016480713.1\|934499_934916_+\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	5.79365e-78
NC_021486.1\|WP_000521427.1\|921652_923005_+\|phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
NC_021486.1\|WP_016480715.1\|937131_939765_+\|pneumococcal-type-histidine-triad-protein	gnl\|CDD\|380193	NF033189, internalin_A, class 1 internalin InlA. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin A (InlA), a class 1 (LPXTG-type) internalin.	3.84632e-22
NC_021486.1\|WP_000159230.1\|923127_923499_+\|YbgA-family-protein	gnl\|CDD\|377982	pfam08349, DUF1722, Protein of unknown function (DUF1722). This domain of unknown function is found in bacteria and archaea and is homologous to the hypothetical protein ybgA from E. coli.	3.86733e-28
NC_021486.1\|WP_144312747.1\|944809_945915_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.59564e-53
NC_021486.1\|WP_016480711.1\|931677_932547_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	2.85005e-135

>NC_021486.1|WP_016480712.1|932871_933537_+|type-II-A-CRISPR-associated-protein-Csn2
MIKINFPILDEPLVLSNATILTIEDVSVYSSLVKHFYQYDVDEHLKLFDDKQKSLKATELMLVTDILGYDVNSAPILKLIHGDLENQFNEKPEVKSMVEKLAATITELIAFECLENELDLEYDEITILELIKALGVKIETQSDTIFEKCFEIIQVYHYLTKKNLLVFVNSGAYLTKDEVIKLCEYINLMQKSVLFLEPRRLYVLPQYVIDKDYFLIGENMV
>NC_021486.1|WP_001904401.1|932543_932885_+|CRISPR-associated-endonuclease-Cas2
MSYRYMRMILMFDMPTETAEERKAYRKFRKFLLSEGFIMHQFSVYSKLLLNNTANNAMIGRLKVNNPKKGSITLLTVTEKQFARMVYLHGERNMSVANSDSRLVFLGDSYDQD
>NC_021486.1|WP_016480711.1|931677_932547_+|type-II-CRISPR-associated-endonuclease-Cas1
MAGWRTVVVNTHSKLSYKNNHLIFKDSYQTEMIHLSEIDILIMETTDIVLSTMLIKRLVDENILVIFCDDKRLPTAMLMPYYARHDSSLQLSRQMSWIEDVKADVWTSIIAQKILNQSFYLGECSFFEKSQSIMNLYHDSEPFDPSNREGHAARIYFNTLLGNDFSREHDNPINAGLDYGYSLLLSMFAREVVKCGCMTQFGLKHANQFNQFNLASDIMEPFRPIVDRIIYENRQSDFVKMKRELFSMFSGTYNYNGKEMYLSNIVSDYTKKVIKSLNSDGNGIPEFRI
>NC_021486.1|WP_016480709.1|926628_927285_+|TIGR01906-family-membrane-protein
MKDKLLVVLTWIWIISLATLATIYIAWLIYPIEIQFLKLEKVVYLKAETIYYNFNKLMTYLTHPFISDLNMPSFPSSEDGLKHFADVKYLFTLAHGLFVILTFPVIYFLRRGWKQKSIFLYEGFFKIAIMMSIFIVVCAFLLGFDQFFTLFHEVLFPGDSTWQFNPLTDPVIWILPETFFLHCFIIFLLIYETITIILLIIGRKHLKLRKYKNKMQAL
>NC_021486.1|WP_000323544.1|925868_926639_+|TIGR01457-family-HAD-type-hydrolase
MAYKGYLIDLDGTIYKGKSRIPAGERFIERLQEKGIPYMLVTNNTTRTPESVQEMLRGFNVETPLETIYTATMATVDYMNDMNRGKTAYVIGEEGLKKAIADAGYVEDTKNPAYVVVGLDWNVTYDKLATATLAIQNGALFIGTNPDLNIPTERGLLPGAGSLNALLEAATRIKPVFIGKPNAIIMNKALEILNIPRNQAVMVGDNYLTDIMAGINNDIDTLLVTTGFTTVEEVPDLPIQPSYVLASLDEWTFNEG
>NC_021486.1|WP_000523795.1|925130_925868_+|acyl-ACP-thioesterase
MGLLYRETYEVPFYESDTNHYMKLPQLLALALQISAKQSLKLGIGDDIVFKRYGLVWVVTDYIIDIERLPKHAEKIVIETEAKAHNKLLCYRYFYIYGEDGQKIITISSAFVLMDFKTRKIHPVLDDITSIYQSQRIKKVIRGPKYHPIGDSKVKQYHVRYFDLDMNGHVNNSKYLEWMYDVLDLDFLSSHIPKKIDLKYIKEIQYGTDIKSHWYQDGLVTRHDIIGGDAIHAQARIEWQEKKED
>NC_021486.1|WP_041165678.1|923996_925127_+|oxygen-independent-coproporphyrinogen-III-oxidase
MLKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDAYLQALIREFRSYDITELRTLYIGGGTPTSISAVQLDYLLTELSRDLNLNTLEEFTIEANPGDLTVDKIEVLQKSAVNRVSLGVQTFNDKHLKRIGRSHNEAQIYSTIDALKTAGFQNISIDLIYALPGQTMDDVRSNVAKALSLNIPHLSLYSLILEHHTVFMNKMRRGKLHLPTEDLEAEMFEYIISEMERNGFEHYEISNFTKPGFESRHNLMYWDNVEYYGVGAGASGYLDGIRYRNRGPIQHYLKGVSEGNARLSEEVLSKNEMMEEELFLGFRKKEGVSIGKFEQKFGTSFEKRYGQIVQELQSDGLLKESNGFIQMTKKGLFLGDTVAEKFIVE
>NC_021486.1|WP_016480707.1|923523_923904_+|hypothetical-protein
MRLWHQDIIELLPRQQLLGQHRECCALRGNGWGRKHETVDYVFRYSPYRLFAYHQLVMEEMMERGYRVSKEWLIAEYRGMKCPRYDTLNPVDLETPIYPEHNQDYLQECLWNLKAKGIDFPINKIK
>NC_021486.1|WP_000159230.1|923127_923499_+|YbgA-family-protein
MTKEAELLWAKHKYLVLSKSQKIYLDIRQTLKSPNCNVLDVQSLIDQAVLLEESPSQVTNAYMHIWGYFKNKAERQEKEEFLTLLEKYRKTGYQRRKLLAFLKQLLAKYPNSYLQNSSIFEEE
>NC_021486.1|WP_000521427.1|921652_923005_+|phosphoglucosamine-mutase
MGKYFGTDGVRGEANVELTPELAFKLGRFGGYVLSQHETDRPRVFVARDTRISGEMLESALIAGLLSVGIEVYKLGVLATPGVSYLVRTEKASAGVMISASHNPALDNGIKFFGSDGFKLDDDRELEIEALLDAKEDTLPRPSAQGLGTLVDYPEGLRKYEKFMESTGIDLEGMKVALDTANGAATASARNIFLDLNADISVIGDQPDGLNINDGVGSTHPEQLQSLVRENGSDIGLAFDGDSDRLIAVDENGEIVDGDKIMFIIGKYLSDKGQLAQNTIVTTVMSNLGFHKALDREGIHKAITAVGDRYVVEEMRKSGYNLGGEQSGHVIIMDYNTTGDGQLTAIQLTKVMKETGKKLSELASEVTIYPQKLVNIRVENNMKDKAMEVPAIAEIIAKMEEEMDGNGRILVRPSGTEPLLRVMAEAPTNEAVDYYVDTIADVVRTEIGLD
>NC_021486.1|WP_041165679.1|933928_934189_+|hypothetical-protein
MLGHHCGVLVFCYTEINFQRMWGKAVIRLIQDVIQNLVSQANEITPVYQFDWETYILATKKYERHLEVCLLAENSNYFSDSKRMCQ
>NC_021486.1|WP_016480713.1|934499_934916_+|nucleoside-diphosphate-kinase
MEQTFFMIKPDGVKRGFIGEVISRIERRGFSIDRLEVRHADADILKRHYAELTDRPFFPTLVDYMISGPVIIGVISGEEVISTWRTMMGSTNPKDALPGTIRGDFAQAPSPNQATCNIVHGSDSPESATREIAIWFNN
>NC_021486.1|WP_001019133.1|935051_936884_+|elongation-factor-4
MNIEDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRAEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGEVDAPLQALIFDSVYDAYRGVILQVRIVNGMVKPGDKIQMMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYIAASIKTVADTRVGDTITLANNPAIEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSEFPDPTRVDSIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYEISEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDDKK
>NC_021486.1|WP_016480715.1|937131_939765_+|pneumococcal-type-histidine-triad-protein
MKGQKIIALAGLVLSCHFALTACHTQEHKNSHHIKTKQVAKKKANKKKVSVKESHKKRKGVAGVDFPTDDGFLLTKDSKILSHTDSGIVVAHGNHSHFIFYSDLKGSKFSYLIPNANAKTNKNQAVRNFKAGAVAVNTLNDGYVFNPADIVSEDANGYVVRHGDHFHYIPKASLSQQKQVQASRAVSRLGNQSNSHYRVNSSKIAGLHHPTSDGFLFNGRGIKGTTPTGILVEHHNHLHFISFADLRKGGWGSIADRYQPQKKADSKKQSPSSKKPRTENTLPKDIKDKLAYLARELHLDISRIRVLKTLNGEIGFEYPHDDHTHVIMAKDIDLSKPIPNPHHDDEDHHKGHHHDESDHKHEEHEHTKSNKLSDEDQKKLIYLAEKLGLNPNQIELLTSEDGSIIFKYPHDDHSHTIASKDIEIGKPIPDGHHEHSHAKDKVGMATLKQIGFDDEIIQDILHADAPTPFPSNETNPEKMRQWLATVTKINIGQRTNPFQRFGLSLMPNIEVLGIGFTPINDMTPVLQFKKLKQLWMTNTGITDYSFLDKMPLLEGLDISQNGIKDLSFLTKYKQLSLIAAANNGITSLKPLAELPNLQFLVLSHNNISDLTPLSNLTKLQELHLDHNNVKNLSALSGKKDLKVLDLSNNKSADLSTLKTTSLETLLLNETNTSNLSFLKQNPKVSNLTINNAKLSSLDGIEESDEIVKVEAEGNQIKSLVLKNKQGSLKFLNVTNNQLTSLEGVNNYTSLETLSVSKNKLESLDIKTPNKTVTNLDFSHNNVPTSQLKLNEKNIPEAVAKNFPAVVEGSMVGNGSLAEKAAMASKEDKQVSDNTNHQKNTEKSAQANADSKKENPKTHDEHHDHEETDHAHVGHHHH
>NC_021486.1|WP_016480716.1|939864_940524_+|HD-domain-containing-protein
MTMVKREDVILNATENMVYHKLKNDPSGHDWFHIVRVRNLAVELAHKEGANTFICQMAALLHDIIDDKICQDSKQASYELTQWLYSQDLAIAEVEHILDILENISFKAGTGLTMKTLEGQIVQDADRLDAMGAIGIARTMAYSGSKGRLIHDPNLKPRENLTLEEYRNGQDTAIMHFYEKLLKLKDLMNTKQGKMLAQKRHDFLELYLAEFYAEWNGKR
>NC_021486.1|WP_016480717.1|940532_940997_+|GNAT-family-N-acetyltransferase
MIRRAKEKDLPDIAELLKQILMLHHEVRPDIFHTRGSKFSKEQLKEMLMDESRPIFVYESDEGKVVAHLFLQLQEKRDLPRKSFKTLYIDDLCIDEEVRGQQIGQKLMDFARQYAKKHGCYNITLNVWNDNQRAVSFYEKLGFKPQQTQMEEIL
>NC_021486.1|WP_000665410.1|940996_941431_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MKETQEELRQRIGHTAYQVTQNSATEHAFTGKYDDFFEEGIYVDIVSGEVLFSSLDKFQSGCGWPAFSKPIENRMVTNHQDHSHGMHRIEVRSRQADSHLGHVFNDGPVDAGGLRYCINSAALDFIPYDQMAKRGYGDYLSLFD
>NC_021486.1|WP_016480718.1|941582_944375_+|cation-transporting-P-type-ATPase
MASTNNVSDTNTRFAKEELEEVFEELGTTQGGLSDEEVAVRQKKYGLNLLSEVKQESIILLFLKNFTSLMAILLWVGGFVAIVSNSLELGLAIWMVNVINGIFSFIQEYRASQATQALKKMLPSYSRVLRKSSEEKILSEQLVPGDIVLIEEGDRISADGRLIKTTDLQVNQSALTGESNPIYKDSNVENDQSKTLIECDNMVFAGTTVSSGSATMVVTAIGMQTQFGQIADLTQGMKSEKSPLQRELDRLTKQISIISITVGIIFFLAATFFVKEPVSKSFIFALGMIVAFIPEGLLPTVTLSLAMAVQRMAKEHALVKKLSSVETLGATSVICSDKTGTLTQNEMTVNRLWQNGKSYQVTGLGYAPEGQILFEGDNICFGNSDRGDLEKLIRFAHLCSNAKVLPPNDDRSTYTVLGDPTEACLNVLLEKSGINRQENRKFAPRLKELPFDSVRKRMTTIHSLGGDEKDKKISITKGAPKEILNLSDYVLSDDKVIPLNKEERNKIQLANDTFAKDGLRVLAVSYCDIEGFSKEQWTQENLEQHMVFIGLIAMSDPPREGVREAIDKCHAASIRIIMVTGDYGLTALSIAKNIGIIRNDDAKVISGLELSEMTDSQLKKELSGEVVFARVAPEQKYRVVTILQEMGEVVAVTGDGVNDAPALKKSDIGVAMGVTGTDVAKESADMILTDDHFASIVHAVEEGRAVYQNIKKFLTYIFNSNTPEAVPSAFFLFSKGFIPLPLTVMQILAVDLGTDMLPALGLGVEPPETDVMNRPPRRLTDRLLDKGLLIKSFLWYGTIESILAMGGFFWAHYLRYGNFTFFVANGISYREATTMTLGAIIFSQIGMVMNSRTSYQSIKTLSIFGNKLINFGIIMEILAFLVLVYVPLFHNLFNTASLGLSHWLYLIGCPFIMIGLDEVRKLFSSRKNKR
>NC_021486.1|WP_144312747.1|944809_945915_-|IS3-family-transposase
MSRKIRRHFTDDFKQQIVDLHNAGRKRSELIKEYDLTPSTFDKWVRQAKLTGSFKSVDNMTDEQRELIQLRKRNKELEMQLDILKQAAVIMVPKREIITANKDKYSISNMCRWLKIPRSSYYYKAVKPVPEAELGEKIKSIFLQSKSRYGARKIKKCLEVLGINLSRRRIRRIMKRLNLVSVYQKATFKPHSKGKNEAPVPNFLERQFNQQKPLETLVTDLTYVRVANRWAYVCLILDLFNREIIGLSLGWHKTADLVKEAIQSIPYALTKVKLFHSDRGKEFDNQLIDEMLEAFGITRSLSQAGCPYDNAVAESTYRSFKLEFINQETFQSLEELALKTKDYVHWWNYHRIHGSLNYQTPMTKRIIA
>NC_021486.1|WP_000146569.1|946817_947456_-|CatB-related-O-acetyltransferase
MASILKKHLEKRLELKNDPMRTDMSTGASYPKYGFSVGKYTYGYQQFFYEGVNLKEIGAFCSIAQNVTITGMNHPTDHITTNPFIYYKSRGFINEDRADLIDEKKNGKVIIGNDVWIGTNVTILPSVTIGNGAIIGAGSVITKDIPDYAVVAGTPAKIIKYRFSEEEITLLNASQWWNWSDEAIKEHISEFSDKKEFFNTLKSISENKNHKL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_021486_1	1.5\|475829\|35\|NC_021486\|CRISPRCasFinder,CRT	475829-475863	35	NC_021486.1	628970-629004	0	1.0
NC_021486_2	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	NC_021486.1	662363-662392	1	0.967

1. spacer 1.5|475829|35|NC_021486|CRISPRCasFinder,CRT matches to position: 628970-629004, mismatch: 0, identity: 1.0

tcccagtccaatgttttattagccatctcagcctc	CRISPR spacer
tcccagtccaatgttttattagccatctcagcctc	Protospacer
***********************************

2. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to position: 662363-662392, mismatch: 1, identity: 0.967

ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ctagtcaaatattgcaagagattagtgaca	Protospacer
********** *******************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	MK448736	Streptococcus phage Javan35, complete genome	11377-11410	0	1.0
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	MK448781	Streptococcus phage Javan5, complete genome	13399-13432	0	1.0
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	MK448938	Streptococcus phage Javan44, complete genome	11377-11410	0	1.0
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	MK448911	Streptococcus phage Javan34, complete genome	11377-11410	0	1.0
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	MK448916	Streptococcus phage Javan36, complete genome	11377-11410	0	1.0
NC_021486_1	1.5\|475829\|35\|NC_021486\|CRISPRCasFinder,CRT	475829-475863	35	MK448796	Streptococcus phage Javan53, complete genome	9028-9062	0	1.0
NC_021486_1	1.5\|475829\|35\|NC_021486\|CRISPRCasFinder,CRT	475829-475863	35	MK448761	Streptococcus phage Javan445, complete genome	6435-6469	0	1.0
NC_021486_1	1.5\|475829\|35\|NC_021486\|CRISPRCasFinder,CRT	475829-475863	35	MK448795	Streptococcus phage Javan527, complete genome	10392-10426	0	1.0
NC_021486_1	1.5\|475829\|35\|NC_021486\|CRISPRCasFinder,CRT	475829-475863	35	MK448760	Streptococcus phage Javan443, complete genome	6435-6469	0	1.0
NC_021486_1	1.5\|475829\|35\|NC_021486\|CRISPRCasFinder,CRT	475829-475863	35	MH853356	Streptococcus phage LF2, partial genome	12151-12185	0	1.0
NC_021486_1	1.2\|475628\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475628-475661	34	JX409894	Streptococcus phage LYGO9, complete genome	4121-4154	1	0.971
NC_021486_2	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	MK448796	Streptococcus phage Javan53, complete genome	42421-42450	1	0.967
NC_021486_1	1.3\|475694\|36\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475694-475729	36	MK448683	Streptococcus phage Javan149, complete genome	16915-16950	2	0.944
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MK448860	Streptococcus phage Javan172, complete genome	19082-19111	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MK448792	Streptococcus phage Javan521, complete genome	19579-19608	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MK448848	Streptococcus phage Javan126, complete genome	16016-16045	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MK448857	Streptococcus phage Javan164, complete genome	16016-16045	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MK448677	Streptococcus phage Javan133, complete genome	17007-17036	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	NC_009018	Streptococcus phage phi3396, complete genome	17246-17275	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MK448679	Streptococcus phage Javan137, complete genome	17593-17622	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	NC_004584	Streptococcus prophage 315.1, complete genome	19172-19201	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MK448682	Streptococcus phage Javan143, complete genome	19248-19277	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MK448770	Streptococcus phage Javan477, complete genome	19579-19608	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MK448978	Streptococcus phage Javan532, complete genome	19067-19096	2	0.933
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MK448785	Streptococcus phage Javan507, complete genome	19067-19096	2	0.933
NC_021486_1	1.4\|475762\|35\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475762-475796	35	JX409894	Streptococcus phage LYGO9, complete genome	5735-5769	3	0.914
NC_021486_2	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	MK448845	Streptococcus phage Javan118, complete genome	30904-30933	4	0.867
NC_021486_2	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	MK448865	Streptococcus phage Javan182, complete genome	26996-27025	5	0.833
NC_021486_2	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	MK448869	Streptococcus phage Javan190, complete genome	31009-31038	5	0.833
NC_021486_2	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	MK448870	Streptococcus phage Javan192, complete genome	31009-31038	5	0.833
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MN657111	Psychrobacter sp. strain ANT_P52 plasmid pA52P3, complete sequence	2774-2803	5	0.833
NC_021486_2	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	MK448951	Streptococcus phage Javan470, complete genome	33801-33830	6	0.8
NC_021486_2	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	NZ_CP046163	Vibrio sp. THAF191c plasmid pTHAF191c_b, complete sequence	1709337-1709366	6	0.8
NC_021486_2	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	NZ_CP046066	Vibrio sp. THAF191d plasmid pTHAF191d_b, complete sequence	44929-44958	6	0.8
NC_021486_2	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	NZ_CP045356	Vibrio sp. THAF64 plasmid pTHAF64_a, complete sequence	1715881-1715910	6	0.8
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	NZ_CP007740	Bacillus methanolicus MGA3 plasmid pBM69, complete sequence	24968-24997	6	0.8
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	NC_012794	Geobacillus sp. WCH70 plasmid pWCH7001, complete sequence	25891-25920	6	0.8
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	NZ_CP053812	Vibrio cholerae strain W6G plasmid pW6G, complete sequence	65747-65776	7	0.767
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	NZ_CP053815	Vibrio cholerae strain W7G plasmid pW7G, complete sequence	21578-21607	7	0.767
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	KX257490	Pseudoalteromonas phage vB_PspS-H6/1, complete genome	23148-23177	7	0.767
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	NC_014496	Listeria grayi plasmid pLGUG1, complete sequence	19706-19735	7	0.767
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MH552532	Siphoviridae sp. isolate ctbf3, complete genome	36770-36799	7	0.767
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NC_014232	Escherichia coli ETEC 1392/75 plasmid p1081, complete sequence	56401-56434	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NC_014232	Escherichia coli ETEC 1392/75 plasmid p1081, complete sequence	61236-61269	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP013191	Escherichia coli strain FORC_031 plasmid pFORC31.1, complete sequence	2166-2199	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP013191	Escherichia coli strain FORC_031 plasmid pFORC31.1, complete sequence	103859-103892	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP017848	Escherichia coli strain FMU073332 plasmid pEcoFMU07332d sequence	77745-77778	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP017848	Escherichia coli strain FMU073332 plasmid pEcoFMU07332d sequence	82580-82613	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP024277	Escherichia coli O6:H16 strain M9682-C1 plasmid unnamed2, complete sequence	67261-67294	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP024277	Escherichia coli O6:H16 strain M9682-C1 plasmid unnamed2, complete sequence	72096-72129	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NC_009786	Escherichia coli O139:H28 str. E24377A plasmid pETEC_80, complete sequence	54244-54277	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NC_009786	Escherichia coli O139:H28 str. E24377A plasmid pETEC_80, complete sequence	59059-59092	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP022914	Escherichia coli O6:H16 strain 2011EL-1370-2 plasmid unnamed2, complete sequence	1785-1818	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP022914	Escherichia coli O6:H16 strain 2011EL-1370-2 plasmid unnamed2, complete sequence	113971-114004	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP024238	Escherichia coli O15:H11 strain 90-9272 plasmid unnamed	68274-68307	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP024237	Escherichia coli O6:H16 strain 2014EL-1346-6 plasmid unnamed5, complete sequence	8519-8552	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP024237	Escherichia coli O6:H16 strain 2014EL-1346-6 plasmid unnamed5, complete sequence	13354-13387	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP024268	Escherichia coli O6:H16 strain F6699 plasmid unnamed2	14867-14900	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP029980	Escherichia coli strain 99-3165 plasmid unnamed2, complete sequence	85975-86008	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP029980	Escherichia coli strain 99-3165 plasmid unnamed2, complete sequence	90810-90843	8	0.765
NC_021486_1	1.1\|475562\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475562-475595	34	NZ_CP024262	Escherichia coli strain F5656C1 plasmid unnamed2, complete sequence	89510-89543	8	0.765
NC_021486_1	1.2\|475628\|34\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475628-475661	34	MN693034	Marine virus AFVG_117M74, complete genome	32767-32800	8	0.765
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	NC_041878	Pectobacterium phage CBB, complete genome	325245-325274	8	0.733
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	NZ_CP011023	Bacillus pumilus strain SH-B9 plasmid pSHB9, complete sequence	84911-84940	8	0.733
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MN693342	Marine virus AFVG_25M9, complete genome	2047-2076	8	0.733
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MN693342	Marine virus AFVG_25M9, complete genome	59198-59227	8	0.733
NC_021486_2	2.2\|933740\|30\|NC_021486\|CRISPRCasFinder,CRT	933740-933769	30	MH494197	Escherichia phage CMSTMSU, complete genome	107346-107375	8	0.733
NC_021486_1	1.4\|475762\|35\|NC_021486\|PILER-CR,CRISPRCasFinder,CRT	475762-475796	35	NZ_LR214973	Mycoplasma bovirhinis strain NCTC10118 plasmid 2	8604-8638	10	0.714

1. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to MK448736 (Streptococcus phage Javan35, complete genome) position: , mismatch: 0, identity: 1.0

tatacaaacttctgcgttatcttcgtcataatta	CRISPR spacer
tatacaaacttctgcgttatcttcgtcataatta	Protospacer
**********************************

2. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to MK448781 (Streptococcus phage Javan5, complete genome) position: , mismatch: 0, identity: 1.0

tatacaaacttctgcgttatcttcgtcataatta	CRISPR spacer
tatacaaacttctgcgttatcttcgtcataatta	Protospacer
**********************************

3. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to MK448938 (Streptococcus phage Javan44, complete genome) position: , mismatch: 0, identity: 1.0

tatacaaacttctgcgttatcttcgtcataatta	CRISPR spacer
tatacaaacttctgcgttatcttcgtcataatta	Protospacer
**********************************

4. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to MK448911 (Streptococcus phage Javan34, complete genome) position: , mismatch: 0, identity: 1.0

tatacaaacttctgcgttatcttcgtcataatta	CRISPR spacer
tatacaaacttctgcgttatcttcgtcataatta	Protospacer
**********************************

5. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to MK448916 (Streptococcus phage Javan36, complete genome) position: , mismatch: 0, identity: 1.0

tatacaaacttctgcgttatcttcgtcataatta	CRISPR spacer
tatacaaacttctgcgttatcttcgtcataatta	Protospacer
**********************************

6. spacer 1.5|475829|35|NC_021486|CRISPRCasFinder,CRT matches to MK448796 (Streptococcus phage Javan53, complete genome) position: , mismatch: 0, identity: 1.0

tcccagtccaatgttttattagccatctcagcctc	CRISPR spacer
tcccagtccaatgttttattagccatctcagcctc	Protospacer
***********************************

7. spacer 1.5|475829|35|NC_021486|CRISPRCasFinder,CRT matches to MK448761 (Streptococcus phage Javan445, complete genome) position: , mismatch: 0, identity: 1.0

tcccagtccaatgttttattagccatctcagcctc	CRISPR spacer
tcccagtccaatgttttattagccatctcagcctc	Protospacer
***********************************

8. spacer 1.5|475829|35|NC_021486|CRISPRCasFinder,CRT matches to MK448795 (Streptococcus phage Javan527, complete genome) position: , mismatch: 0, identity: 1.0

tcccagtccaatgttttattagccatctcagcctc	CRISPR spacer
tcccagtccaatgttttattagccatctcagcctc	Protospacer
***********************************

9. spacer 1.5|475829|35|NC_021486|CRISPRCasFinder,CRT matches to MK448760 (Streptococcus phage Javan443, complete genome) position: , mismatch: 0, identity: 1.0

tcccagtccaatgttttattagccatctcagcctc	CRISPR spacer
tcccagtccaatgttttattagccatctcagcctc	Protospacer
***********************************

10. spacer 1.5|475829|35|NC_021486|CRISPRCasFinder,CRT matches to MH853356 (Streptococcus phage LF2, partial genome) position: , mismatch: 0, identity: 1.0

tcccagtccaatgttttattagccatctcagcctc	CRISPR spacer
tcccagtccaatgttttattagccatctcagcctc	Protospacer
***********************************

11. spacer 1.2|475628|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to JX409894 (Streptococcus phage LYGO9, complete genome) position: , mismatch: 1, identity: 0.971

aagtgggttagtacaactgaatgggatgaaaaac	CRISPR spacer
aagtgggttagtacaactggatgggatgaaaaac	Protospacer
*******************.**************

12. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to MK448796 (Streptococcus phage Javan53, complete genome) position: , mismatch: 1, identity: 0.967

ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ctagtcaaatattgcaagagattagtgaca	Protospacer
********** *******************

13. spacer 1.3|475694|36|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to MK448683 (Streptococcus phage Javan149, complete genome) position: , mismatch: 2, identity: 0.944

ctaaaggtgtcttatgggattcgaacccatagtggc	CRISPR spacer
ctaaaggtatcttatgggattcgaacccatagtagc	Protospacer
********.************************.**

14. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MK448860 (Streptococcus phage Javan172, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

15. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MK448792 (Streptococcus phage Javan521, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

16. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MK448848 (Streptococcus phage Javan126, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

17. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MK448857 (Streptococcus phage Javan164, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

18. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MK448677 (Streptococcus phage Javan133, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

19. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to NC_009018 (Streptococcus phage phi3396, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

20. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MK448679 (Streptococcus phage Javan137, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

21. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to NC_004584 (Streptococcus prophage 315.1, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

22. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MK448682 (Streptococcus phage Javan143, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

23. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MK448770 (Streptococcus phage Javan477, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

24. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MK448978 (Streptococcus phage Javan532, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

25. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MK448785 (Streptococcus phage Javan507, complete genome) position: , mismatch: 2, identity: 0.933

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gatcttttagttttttgatgtcatctacat	Protospacer
*.*********************** ****

26. spacer 1.4|475762|35|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to JX409894 (Streptococcus phage LYGO9, complete genome) position: , mismatch: 3, identity: 0.914

atgcattgatgtaactttctatattattgacaact	CRISPR spacer
gtgcattactgtaactttctatattattgacaact	Protospacer
.******. **************************

27. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to MK448845 (Streptococcus phage Javan118, complete genome) position: , mismatch: 4, identity: 0.867

ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ctagtcaaatctcgcaagagattagagatc	Protospacer
************.************ **.

28. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to MK448865 (Streptococcus phage Javan182, complete genome) position: , mismatch: 5, identity: 0.833

ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ctagtcaaatctcacaagagattaaggata	Protospacer
************..**********. **.*

29. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to MK448869 (Streptococcus phage Javan190, complete genome) position: , mismatch: 5, identity: 0.833

ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ctagtcaaatctcacaagagattaaggata	Protospacer
************..**********. **.*

30. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to MK448870 (Streptococcus phage Javan192, complete genome) position: , mismatch: 5, identity: 0.833

ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ctagtcaaatctcacaagagattaaggata	Protospacer
************..**********. **.*

31. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MN657111 (Psychrobacter sp. strain ANT_P52 plasmid pA52P3, complete sequence) position: , mismatch: 5, identity: 0.833

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
agtcttttagttttatgatttcatcaaact	Protospacer
.************* **** *******  *

32. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to MK448951 (Streptococcus phage Javan470, complete genome) position: , mismatch: 6, identity: 0.8

ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ctagtcaaatctcacaagagattaaaaacc	Protospacer
************..**********. .**

33. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to NZ_CP046163 (Vibrio sp. THAF191c plasmid pTHAF191c_b, complete sequence) position: , mismatch: 6, identity: 0.8

--ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ggcta--caaatcttccaagagagtagtgaag	Protospacer
  ***  ******** ******* ****** .

34. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to NZ_CP046066 (Vibrio sp. THAF191d plasmid pTHAF191d_b, complete sequence) position: , mismatch: 6, identity: 0.8

--ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ggcta--caaatcttccaagagagtagtgaag	Protospacer
  ***  ******** ******* ****** .

35. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to NZ_CP045356 (Vibrio sp. THAF64 plasmid pTHAF64_a, complete sequence) position: , mismatch: 6, identity: 0.8

--ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ggcta--caaatcttccaagagagtagtgaag	Protospacer
  ***  ******** ******* ****** .

36. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to NZ_CP007740 (Bacillus methanolicus MGA3 plasmid pBM69, complete sequence) position: , mismatch: 6, identity: 0.8

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gacgttttagatttttgatgtcatctacct	Protospacer
*.. ****** ************** ** *

37. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to NC_012794 (Geobacillus sp. WCH70 plasmid pWCH7001, complete sequence) position: , mismatch: 6, identity: 0.8

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
ggcgctttagatttttgatgtcatctacct	Protospacer
**. .***** ************** ** *

38. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to NZ_CP053812 (Vibrio cholerae strain W6G plasmid pW6G, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
taacttttagttttttgatttcatccgtat	Protospacer
 . **************** ***** ..**

39. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to NZ_CP053815 (Vibrio cholerae strain W7G plasmid pW7G, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
taacttttagttttttgatttcatccgtat	Protospacer
 . **************** ***** ..**

40. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to KX257490 (Pseudoalteromonas phage vB_PspS-H6/1, complete genome) position: , mismatch: 7, identity: 0.767

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
cgtcttttagttttttgatggcagactctt	Protospacer
 ******************* **    * *

41. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to NC_014496 (Listeria grayi plasmid pLGUG1, complete sequence) position: , mismatch: 7, identity: 0.767

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
tctcttttagttttttgatttcttcttctt	Protospacer
  ***************** ** **  * *

42. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MH552532 (Siphoviridae sp. isolate ctbf3, complete genome) position: , mismatch: 7, identity: 0.767

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gttgggttagttttttgatgttatcaaaac	Protospacer
* *   ***************.***** *.

43. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NC_014232 (Escherichia coli ETEC 1392/75 plasmid p1081, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

44. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NC_014232 (Escherichia coli ETEC 1392/75 plasmid p1081, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

45. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013191 (Escherichia coli strain FORC_031 plasmid pFORC31.1, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

46. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013191 (Escherichia coli strain FORC_031 plasmid pFORC31.1, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

47. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017848 (Escherichia coli strain FMU073332 plasmid pEcoFMU07332d sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

48. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017848 (Escherichia coli strain FMU073332 plasmid pEcoFMU07332d sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

49. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024277 (Escherichia coli O6:H16 strain M9682-C1 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

50. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024277 (Escherichia coli O6:H16 strain M9682-C1 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

51. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NC_009786 (Escherichia coli O139:H28 str. E24377A plasmid pETEC_80, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

52. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NC_009786 (Escherichia coli O139:H28 str. E24377A plasmid pETEC_80, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

53. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022914 (Escherichia coli O6:H16 strain 2011EL-1370-2 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

54. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022914 (Escherichia coli O6:H16 strain 2011EL-1370-2 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

55. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024238 (Escherichia coli O15:H11 strain 90-9272 plasmid unnamed) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

56. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024237 (Escherichia coli O6:H16 strain 2014EL-1346-6 plasmid unnamed5, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

57. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024237 (Escherichia coli O6:H16 strain 2014EL-1346-6 plasmid unnamed5, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

58. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024268 (Escherichia coli O6:H16 strain F6699 plasmid unnamed2) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

59. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029980 (Escherichia coli strain 99-3165 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

60. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029980 (Escherichia coli strain 99-3165 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

61. spacer 1.1|475562|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024262 (Escherichia coli strain F5656C1 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

tataca-aacttctgcgttatcttcgtcataatta	CRISPR spacer
-gcgcagaacttctgcgttttcttcgtcaaaaaaa	Protospacer
 ...** ************ ********* **  *

62. spacer 1.2|475628|34|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to MN693034 (Marine virus AFVG_117M74, complete genome) position: , mismatch: 8, identity: 0.765

aagtgggttagtacaactgaatgggatgaaaaac	CRISPR spacer
tatttagatggtacaactaaatggtatgaaaaac	Protospacer
 * * .* *.********.***** *********

63. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to NC_041878 (Pectobacterium phage CBB, complete genome) position: , mismatch: 8, identity: 0.733

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
cttcttttagatttttgatttcatcatttg	Protospacer
  ******** ******** ****** .

64. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to NZ_CP011023 (Bacillus pumilus strain SH-B9 plasmid pSHB9, complete sequence) position: , mismatch: 8, identity: 0.733

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
gcacttttcgttttttgaggtcatcattca	Protospacer
*  ***** ********* ******* .

65. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MN693342 (Marine virus AFVG_25M9, complete genome) position: , mismatch: 8, identity: 0.733

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
tttcttttagttgtttaatgtcatctgaaa	Protospacer
  ********** ***.******** . *

66. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MN693342 (Marine virus AFVG_25M9, complete genome) position: , mismatch: 8, identity: 0.733

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
tttcttttagttgtttaatgtcatctgaaa	Protospacer
  ********** ***.******** . *

67. spacer 2.2|933740|30|NC_021486|CRISPRCasFinder,CRT matches to MH494197 (Escherichia phage CMSTMSU, complete genome) position: , mismatch: 8, identity: 0.733

ggtcttttagttttttgatgtcatcaacat	CRISPR spacer
aaccttttagttctttgatgtaatcattaa	Protospacer
...*********.******** **** .*

68. spacer 1.4|475762|35|NC_021486|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR214973 (Mycoplasma bovirhinis strain NCTC10118 plasmid 2) position: , mismatch: 10, identity: 0.714

atgcattgatgtaactttctatattattgacaact	CRISPR spacer
tagcataaatgtaactttctatattatttagtgta	Protospacer
  **** .******************** *  ..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

40492 : 48568

Synechococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016480155.1\|40492_41947_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.3e-54	32.9
WP_016480156.1\|41974_42997_+	phosphoribosylformylglycinamidine cyclo-ligase	R9TMC7	Synechococcus_phage	5.8e-62	41.7
WP_016480157.1\|43164_43713_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.8e-25	34.4
WP_016480158.1\|43735_44488_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_016480159.1\|44507_46055_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	4.3e-77	48.9
WP_001045908.1\|46247_47147_+	peptidoglycan DD-metalloendopeptidase family protein	A0A221J6U0	Arthrobacter_phage	4.1e-19	45.9
WP_016480160.1\|47293_48568_+	LysM peptidoglycan-binding domain-containing protein	A0A2D1GNZ3	Streptomyces_phage	1.6e-05	40.5

DBSCAN-SWA_2

584351 : 590913

Streptococcus_phage(87.5%)

transposase,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016480195.1\|584351_584627_+\|transposase	transposase	A0A1P8CWP5	Bacillus_phage	1.0e-13	43.5
WP_016480474.1\|585245_585539_+	hypothetical protein	J7KH30	Streptococcus_phage	1.2e-39	91.5
WP_016480475.1\|585541_585769_+\|holin	phage holin	A7J2B3	Streptococcus_phage	3.0e-27	90.7
WP_016480477.1\|585896_587231_+	N-acetylmuramoyl-L-alanine amidase	Q5MY96	Streptococcus_phage	7.9e-245	91.2
WP_000634506.1\|587596_588109_+	hypothetical protein	NA	NA	NA	NA
WP_016480478.1\|588268_588469_+	CsbD family protein	J7KJ36	Streptococcus_phage	4.3e-22	89.4
WP_016480479.1\|588640_588871_+	hypothetical protein	NA	NA	NA	NA
WP_016480480.1\|588896_589322_+	hypothetical protein	C5IUL6	Streptococcus_phage	1.9e-35	55.5
WP_041165659.1\|589381_589738_-	hypothetical protein	NA	NA	NA	NA
WP_016480482.1\|589670_590213_-	hypothetical protein	A3F671	Streptococcus_phage	3.4e-77	89.7
WP_016480483.1\|590251_590491_-	hypothetical protein	NA	NA	NA	NA
WP_016480484.1\|590706_590913_+	hypothetical protein	J7KBZ4	Streptococcus_phage	2.1e-19	79.7

DBSCAN-SWA_3

615037 : 699737

107

Streptococcus_phage(58.67%)

transposase,holin,tail,capsid,terminase,head,integrase

attL 618731:618747|attR 628521:628537

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016480499.1\|615037_616405_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	F5CA72	Streptococcus_phi-m46.1-like_phage	2.6e-190	72.7
WP_041165661.1\|616653_616848_+	hypothetical protein	NA	NA	NA	NA
WP_016480500.1\|616878_617643_+	DNA (cytosine-5-)-methyltransferase	Q83VT0	Escherichia_phage	1.5e-62	49.0
WP_144312746.1\|617660_618805_-\|transposase	IS3 family transposase	A0A1P8CWP5	Bacillus_phage	3.4e-10	39.5
618731:618747	attL	NA	NA	NA	NA
WP_001872860.1\|619283_619763_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_016480502.1\|619942_621097_-\|integrase	site-specific integrase	Q938N9	Temperate_phage	1.0e-200	96.4
WP_016480503.1\|621216_621483_-	hypothetical protein	M1PF81	Streptococcus_phage	4.7e-08	86.7
WP_016480504.1\|621550_622108_-	hypothetical protein	Q0H269	Geobacillus_phage	1.6e-18	30.2
WP_016480505.1\|622109_622907_-	XRE family transcriptional regulator	A0A1S5S8S8	Streptococcus_phage	4.8e-64	74.1
WP_016480506.1\|623270_623450_+	hypothetical protein	M1Q149	Streptococcus_phage	7.3e-05	46.8
WP_016480507.1\|623429_623627_-	hypothetical protein	M1PRU3	Streptococcus_phage	4.3e-14	63.1
WP_001104149.1\|623685_623844_+	hypothetical protein	J7KH24	Streptococcus_phage	2.2e-21	92.3
WP_016480508.1\|623874_624063_+	hypothetical protein	NA	NA	NA	NA
WP_016480509.1\|624045_624852_-	DUF4393 domain-containing protein	A0A1S5SD60	Streptococcus_phage	1.9e-28	36.5
WP_001166512.1\|624903_625092_+	helix-turn-helix transcriptional regulator	A0A0B5A7F0	Streptococcus_phage	1.8e-14	65.0
WP_016480510.1\|625139_626051_+	hypothetical protein	J7KDG2	Streptococcus_phage	3.1e-123	85.1
WP_016480511.1\|626043_626553_+	ORF6C domain-containing protein	J7KJY1	Streptococcus_phage	3.9e-83	98.8
WP_016480512.1\|626563_626749_+	hypothetical protein	A0A141E0V7	Streptococcus_phage	1.0e-09	55.4
WP_016480513.1\|626726_626966_-	hypothetical protein	A0A1X9I5M1	Streptococcus_phage	3.1e-35	81.0
WP_016480514.1\|627014_627206_+	hypothetical protein	NA	NA	NA	NA
WP_016480515.1\|627233_627410_-	hypothetical protein	NA	NA	NA	NA
WP_079269280.1\|627619_627781_+	helix-turn-helix transcriptional regulator	J7KH19	Streptococcus_phage	5.6e-20	90.6
WP_016480517.1\|627859_628117_+	hypothetical protein	NA	NA	NA	NA
WP_000214000.1\|628411_628591_+	hypothetical protein	A0A1X9I5M8	Streptococcus_phage	1.2e-12	65.5
628521:628537	attR	NA	NA	NA	NA
WP_000370473.1\|628762_629035_+	hypothetical protein	NA	NA	NA	NA
WP_000568479.1\|629024_629405_-	hypothetical protein	NA	NA	NA	NA
WP_001074391.1\|629460_629907_+	hypothetical protein	G4KNN0	Staphylococcus_phage	5.9e-11	32.7
WP_016480518.1\|630023_630707_+	DnaD domain protein	A0A1P8BL54	Lactococcus_phage	1.8e-38	68.6
WP_016480519.1\|630693_631476_+	ATP-binding protein	A0A097PAQ0	Streptococcus_pyogenes_phage	7.4e-134	90.4
WP_016480520.1\|631466_631610_+	hypothetical protein	J7KBQ4	Streptococcus_phage	4.3e-16	91.3
WP_124759159.1\|631662_632807_-\|transposase	IS3 family transposase	A0A1P8CWP5	Bacillus_phage	3.4e-10	39.5
WP_041165743.1\|632877_633141_+	hypothetical protein	J7KJY6	Streptococcus_phage	3.1e-20	59.5
WP_016480522.1\|633127_633382_+	hypothetical protein	J7KK18	Streptococcus_phage	2.2e-34	82.1
WP_016480524.1\|633546_634029_+	siphovirus Gp157 family protein	A0A1P8VVS5	Streptococcus_phage	5.3e-50	67.5
WP_016480525.1\|634029_634704_+	ERF family protein	Q938M8	Temperate_phage	2.8e-97	84.8
WP_016480526.1\|634696_635113_+	single-stranded DNA-binding protein	M1NRI2	Streptococcus_phage	2.5e-56	80.4
WP_041165663.1\|635115_635319_+	hypothetical protein	J7KIX6	Streptococcus_phage	2.3e-23	87.3
WP_016480527.1\|635308_635785_+	RusA family crossover junction endodeoxyribonuclease	J7KBT1	Streptococcus_phage	2.5e-60	99.1
WP_041165664.1\|635774_636122_+	hypothetical protein	J7KK12	Streptococcus_phage	7.7e-51	82.6
WP_041165665.1\|636133_636406_+	DUF1599 domain-containing protein	J7KBY0	Streptococcus_phage	2.4e-31	74.2
WP_016480529.1\|636405_636768_+	hypothetical protein	F8HGR8	Streptococcus_phage	6.2e-19	49.4
WP_041165744.1\|636770_637040_+	membrane protein	A7J287	Streptococcus_phage	9.3e-20	60.7
WP_173390332.1\|637041_637206_+	hypothetical protein	NA	NA	NA	NA
WP_016480531.1\|637195_637720_+	DUF1642 domain-containing protein	A0A097PAV5	Streptococcus_pyogenes_phage	4.6e-23	41.0
WP_016480532.1\|637915_638149_+	hypothetical protein	NA	NA	NA	NA
WP_000142570.1\|638490_638925_+	ArpU family transcriptional regulator	J7KDQ1	Streptococcus_phage	6.5e-71	95.1
WP_016480534.1\|639597_639981_-	type II toxin-antitoxin system HicB family antitoxin	I3NLB2	Bifidobacterium_phage	4.0e-16	40.5
WP_001138286.1\|640024_640213_-	type II toxin-antitoxin system HicA family toxin	F0PIL1	Enterococcus_phage	7.7e-05	44.4
WP_079269281.1\|640315_640807_+\|terminase	terminase small subunit	U6E976	Streptococcus_phage	1.1e-34	51.6
WP_016480536.1\|640796_642032_+\|terminase	PBSX family phage terminase large subunit	C9W9H4	Streptococcus_virus	8.0e-175	71.8
WP_144312747.1\|643253_644359_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	6.3e-70	51.3
WP_016480540.1\|646005_646977_+\|capsid	minor capsid protein	U6E9F1	Streptococcus_phage	3.6e-53	37.1
WP_016480541.1\|647194_647773_+	DUF4355 domain-containing protein	A0A0P0IXG5	Lactobacillus_phage	1.1e-06	36.5
WP_016480542.1\|647782_648163_+	hypothetical protein	A0A286QPB3	Streptococcus_phage	5.6e-10	37.8
WP_016480543.1\|648165_649218_+\|capsid	major capsid protein	A0A286QR01	Streptococcus_phage	6.5e-109	58.9
WP_016480544.1\|649230_649485_+	hypothetical protein	NA	NA	NA	NA
WP_016480545.1\|649500_649854_+\|head,tail	phage head-tail connector protein	A0A2H4J002	uncultured_Caudovirales_phage	1.2e-27	53.8
WP_016480546.1\|649850_650150_+	hypothetical protein	A0A286QRJ8	Streptococcus_phage	3.5e-07	36.9
WP_016480547.1\|650142_650526_+	hypothetical protein	B5SP35	Lactococcus_phage	1.2e-17	43.7
WP_016480548.1\|650522_650909_+	DUF3168 domain-containing protein	W6LLG8	Streptococcus_phage	8.4e-30	47.7
WP_016480549.1\|650917_651451_+\|tail	phage major tail protein, TP901-1 family	L0P2Q8	Streptococcus_phage	3.0e-46	58.7
WP_016480550.1\|651523_651883_+	hypothetical protein	O34069	Streptococcus_phage	7.1e-23	47.9
WP_025194532.1\|651984_652263_+	hypothetical protein	A0A0S2MYH1	Enterococcus_phage	7.7e-09	41.0
WP_016480551.1\|652255_654904_+\|tail	phage tail tape measure protein	Q9G097	Lactococcus_phage	5.3e-107	54.9
WP_016480552.1\|654904_656479_+\|tail	phage tail family protein	J7KH53	Streptococcus_phage	8.5e-238	78.1
WP_016480554.1\|660086_660854_+	collagen-like protein	Q938K0	Temperate_phage	4.7e-16	75.0
WP_016480555.1\|660855_661440_+	hypothetical protein	A3F658	Streptococcus_phage	8.8e-31	34.5
WP_016480556.1\|661449_663426_+	gp58-like family protein	Q938J9	Temperate_phage	1.1e-114	57.1
WP_016480557.1\|663439_663598_+	hypothetical protein	NA	NA	NA	NA
WP_016480558.1\|663600_664221_+	DUF1366 domain-containing protein	Q938J7	Temperate_phage	1.2e-70	81.4
WP_016480559.1\|664231_664534_+	hypothetical protein	J7KH30	Streptococcus_phage	4.5e-39	91.3
WP_016480560.1\|664526_664781_+\|holin	phage holin	J7KDR1	Streptococcus_phage	4.5e-32	84.5
WP_016480561.1\|664908_666252_+	N-acetylmuramoyl-L-alanine amidase	Q5MY96	Streptococcus_phage	8.3e-250	92.6
WP_016480563.1\|668527_668863_-	hypothetical protein	A0A1P8VVU1	Streptococcus_phage	1.1e-30	63.1
WP_016480564.1\|668875_669100_-	hypothetical protein	J7KBY5	Streptococcus_phage	8.0e-33	87.8
WP_016480565.1\|669302_670049_-	phage antirepressor Ant	A0A2P0VG01	Streptococcus_phage	7.6e-96	70.9
WP_016480566.1\|670379_670739_+	hypothetical protein	NA	NA	NA	NA
WP_016480567.1\|670722_670926_-	hypothetical protein	NA	NA	NA	NA
WP_016480569.1\|671066_671255_-	hypothetical protein	NA	NA	NA	NA
WP_001104152.1\|671285_671444_-	hypothetical protein	J7KH24	Streptococcus_phage	6.9e-23	96.2
WP_000274022.1\|671501_671684_+	DUF1508 domain-containing protein	NA	NA	NA	NA
WP_001113676.1\|671803_671947_-	hypothetical protein	Q938N4	Temperate_phage	1.3e-15	95.2
WP_016480571.1\|672303_673068_+	helix-turn-helix transcriptional regulator	J7KJ52	Streptococcus_phage	1.2e-83	64.9
WP_016480504.1\|673069_673627_+	hypothetical protein	Q0H269	Geobacillus_phage	1.6e-18	30.2
WP_016480572.1\|673694_673961_+	hypothetical protein	M1PF81	Streptococcus_phage	4.7e-08	86.7
WP_124759159.1\|674851_675996_-\|transposase	IS3 family transposase	A0A1P8CWP5	Bacillus_phage	3.4e-10	39.5
WP_016480574.1\|676113_676287_+	Maf family protein	NA	NA	NA	NA
WP_041165668.1\|676360_677059_+	noncanonical pyrimidine nucleotidase, YjjG family	NA	NA	NA	NA
WP_016480576.1\|677276_677945_+	response regulator transcription factor	NA	NA	NA	NA
WP_016480577.1\|677976_678534_+	HAMP domain-containing protein	NA	NA	NA	NA
WP_016480578.1\|678539_679064_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	1.3e-22	33.5
WP_016480579.1\|679472_679778_+	hypothetical protein	NA	NA	NA	NA
WP_016480580.1\|679777_680626_+	hypothetical protein	NA	NA	NA	NA
WP_016480581.1\|680622_681345_+	3-oxoacyl-ACP reductase FabG	Q06VL0	Trichoplusia_ni_ascovirus	1.9e-14	31.7
WP_000611494.1\|681337_681643_+	acyl carrier protein	NA	NA	NA	NA
WP_041165669.1\|681626_682103_+	3-hydroxyacyl-ACP dehydratase FabZ	NA	NA	NA	NA
WP_000403525.1\|682092_683022_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.6e-24	30.6
WP_016480583.1\|683014_683893_+	ABC transporter permease	NA	NA	NA	NA
WP_016480584.1\|683889_685893_+	hypothetical protein	NA	NA	NA	NA
WP_016480585.1\|685889_686843_+	aminomethyl transferase family protein	NA	NA	NA	NA
WP_041165670.1\|686839_689035_+	cylI protein	NA	NA	NA	NA
WP_016480587.1\|689039_690251_+	hypothetical protein	NA	NA	NA	NA
WP_001068960.1\|690219_690795_+	hypothetical protein	NA	NA	NA	NA
WP_001288728.1\|691136_691478_+	hypothetical protein	NA	NA	NA	NA
WP_079269282.1\|691511_698228_+	S8 family serine peptidase	A0A217EQY2	Bacillus_phage	1.0e-13	32.6
WP_016480589.1\|698411_698579_+	hypothetical protein	NA	NA	NA	NA
WP_144312748.1\|698592_699737_-\|transposase	IS3 family transposase	A0A1P8CWP5	Bacillus_phage	3.4e-10	39.5

DBSCAN-SWA_4

765300 : 771564

Staphylococcus_phage(50.0%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000975997.1\|765300_766410_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	1.2e-55	37.2
WP_016480625.1\|766390_767041_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	2.3e-35	40.9
WP_016480626.1\|767058_768210_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	3.1e-104	50.9
WP_144312750.1\|768223_769368_-\|transposase	IS3 family transposase	A0A1P8CWP5	Bacillus_phage	3.4e-10	39.5
WP_000152414.1\|769528_769999_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.3e-40	52.7
WP_000070708.1\|770073_771564_-\|tRNA	lysine--tRNA ligase	A0A1V0SAC0	Catovirus	5.8e-87	38.5

DBSCAN-SWA_5

1504900 : 1557307

Paenibacillus_phage(13.33%)

transposase,protease,holin,integrase

attL 1510773:1510832|attR 1551070:1551419

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_079269295.1\|1504900_1505155_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000551533.1\|1505883_1506285_-	hypothetical protein	NA	NA	NA	NA
WP_000143288.1\|1506521_1507421_-	GTPase Era	NA	NA	NA	NA
WP_000365220.1\|1507462_1507861_-	diacylglycerol kinase family protein	NA	NA	NA	NA
WP_001867191.1\|1507841_1508339_-	rRNA maturation RNase YbeY	NA	NA	NA	NA
WP_016481054.1\|1508733_1509540_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_144312756.1\|1509995_1511142_+\|transposase	IS3 family transposase	A0A1P8CWP5	Bacillus_phage	3.4e-10	39.5
1510773:1510832	attL	NA	NA	NA	NA
WP_144312757.1\|1511190_1512295_+\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	6.3e-70	51.3
WP_016481057.1\|1512374_1512821_-	NUDIX domain-containing protein	NA	NA	NA	NA
WP_000349559.1\|1513012_1513816_+	DUF4037 domain-containing protein	NA	NA	NA	NA
WP_001158916.1\|1513906_1514893_-	PhoH family protein	W8D063	Erwinia_phage	1.3e-47	48.5
WP_016481058.1\|1515016_1516789_-	oleate hydratase	NA	NA	NA	NA
WP_001232076.1\|1516945_1517161_-	YozE family protein	NA	NA	NA	NA
WP_016481059.1\|1517157_1517667_-	peptide-methionine (S)-S-oxide reductase MsrA	NA	NA	NA	NA
WP_016481060.1\|1517804_1518659_-	RNA-binding virulence regulatory protein CvfB	NA	NA	NA	NA
WP_016481061.1\|1518776_1519334_-	ribosome recycling factor	NA	NA	NA	NA
WP_000433491.1\|1519349_1520078_-	UMP kinase	NA	NA	NA	NA
WP_016481062.1\|1520198_1520879_-	ABC transporter ATP-binding protein	F2Y1V5	Organic_Lake_phycodnavirus	3.1e-11	30.4
WP_016481063.1\|1520865_1521654_-	ABC transporter ATP-binding protein	F2Y1V6	Organic_Lake_phycodnavirus	2.8e-08	28.5
WP_000044261.1\|1521641_1522448_-	ABC transporter permease	NA	NA	NA	NA
WP_000281512.1\|1522447_1523392_-	ABC transporter permease	NA	NA	NA	NA
WP_016481064.1\|1523378_1524995_-	nickel ABC transporter, nickel/metallophore periplasmic binding protein	NA	NA	NA	NA
WP_001085664.1\|1525384_1526074_-	50S ribosomal protein L1	NA	NA	NA	NA
WP_001085802.1\|1526177_1526603_-	50S ribosomal protein L11	NA	NA	NA	NA
WP_000958259.1\|1526813_1528196_-	MFS transporter	NA	NA	NA	NA
WP_016481065.1\|1528203_1529418_-	amidohydrolase	NA	NA	NA	NA
WP_000795892.1\|1529676_1530582_+	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	7.3e-24	27.9
WP_000639447.1\|1530642_1530996_+	DUF3397 domain-containing protein	NA	NA	NA	NA
WP_016481066.1\|1531024_1532740_-	aminodeoxychorismate synthase component I	S4VT78	Pandoravirus	2.0e-35	30.8
WP_016481067.1\|1532821_1535272_-	DNA translocase FtsK	S5VNE3	Mycobacterium_phage	3.9e-88	51.7
WP_016481068.1\|1535437_1536241_+	peptidylprolyl isomerase	A0A2H4UTF4	Bodo_saltans_virus	4.3e-20	37.8
WP_000494350.1\|1536292_1537126_-	metal ABC transporter permease	NA	NA	NA	NA
WP_016481069.1\|1537127_1537844_-	metal ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	4.3e-19	32.5
WP_016481070.1\|1538014_1538941_-	metal ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000188490.1\|1539107_1539755_+	metal-dependent transcriptional regulator	NA	NA	NA	NA
WP_000689759.1\|1539794_1540484_-	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	NA	NA	NA	NA
WP_016481071.1\|1540493_1540763_-	hypothetical protein	NA	NA	NA	NA
WP_016481072.1\|1540762_1541317_-	NUDIX hydrolase	NA	NA	NA	NA
WP_016481073.1\|1541337_1542717_-	bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU	A0A2K9L4K9	Tupanvirus	2.6e-33	37.2
WP_016481074.1\|1542960_1543374_-	VOC family protein	NA	NA	NA	NA
WP_000625774.1\|1543386_1543764_-	VOC family protein	NA	NA	NA	NA
WP_016481075.1\|1543852_1544809_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_016481076.1\|1544805_1545258_-	ASCH domain-containing protein	NA	NA	NA	NA
WP_016481077.1\|1545496_1546195_-	3-oxoacyl-ACP reductase	NA	NA	NA	NA
WP_000141918.1\|1546187_1546424_-	DUF2829 domain-containing protein	NA	NA	NA	NA
WP_016481078.1\|1546519_1547665_-\|integrase	site-specific integrase	A0A1X9I5Y5	Streptococcus_phage	3.6e-97	49.2
WP_016481079.1\|1547992_1548136_+\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_001137532.1\|1548801_1549011_-	TM2 domain-containing protein	NA	NA	NA	NA
WP_016481081.1\|1549119_1549752_-	helix-turn-helix transcriptional regulator	A0A1X9I723	Streptococcus_phage	1.3e-16	61.4
WP_016481082.1\|1549974_1550175_+	transcriptional regulator	NA	NA	NA	NA
WP_016481083.1\|1550198_1550744_+	phage repressor protein	A0A2H4JB17	uncultured_Caudovirales_phage	1.2e-37	45.4
WP_000752173.1\|1551762_1552296_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
1551070:1551419	attR	NA	NA	NA	NA
WP_016481086.1\|1552542_1553955_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_144312747.1\|1556201_1557307_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	6.3e-70	51.3

DBSCAN-SWA_6

1569781 : 1580506

Streptococcus_phage(83.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016481097.1\|1569781_1570609_+	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	9.6e-124	77.7
WP_000287943.1\|1570648_1571005_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	5.2e-42	72.6
WP_016481100.1\|1571538_1572720_-	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	1.7e-166	75.1
WP_016481101.1\|1572782_1573331_-	acetyltransferase	M1PSC3	Streptococcus_phage	1.2e-53	57.9
WP_016481102.1\|1573398_1574490_-	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	1.7e-165	78.0
WP_016481103.1\|1574622_1575258_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_016481104.1\|1575527_1576397_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.1e-109	70.4
WP_016481105.1\|1576396_1576717_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	9.1e-30	61.3
WP_000364568.1\|1576746_1577610_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	2.5e-74	50.0
WP_000715591.1\|1577629_1578265_-	dTMP kinase	M1PSC7	Streptococcus_phage	4.9e-67	61.1
WP_001144245.1\|1578353_1579013_-	CBS domain-containing protein	M1NSC5	Streptococcus_phage	8.0e-65	56.0
WP_000178146.1\|1579031_1579742_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.7e-18	28.5
WP_001185985.1\|1579741_1580506_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.6e-14	24.8

DBSCAN-SWA_7

2058314 : 2068097

Streptococcus_phage(87.5%)

integrase

attL 2059187:2059203|attR 2070804:2070820

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041165785.1\|2058314_2058845_-	hypothetical protein	A0A1X9I5U4	Streptococcus_phage	1.2e-50	58.5
2059187:2059203	attL	NA	NA	NA	NA
WP_016481374.1\|2060307_2061804_-	DNA primase phage associated	Q9AZI5	Lactococcus_phage	1.5e-63	37.2
WP_016481375.1\|2061823_2062693_-	primase C-terminal domain-containing protein	A0A1X9I6L2	Streptococcus_phage	1.7e-123	73.7
WP_041165715.1\|2062827_2063109_-	hypothetical protein	A0A1X9I5U9	Streptococcus_phage	2.9e-32	74.4
WP_016481376.1\|2063101_2063434_-	hypothetical protein	NA	NA	NA	NA
WP_016481377.1\|2063430_2063664_-	hypothetical protein	NA	NA	NA	NA
WP_016481378.1\|2063665_2063917_-	hypothetical protein	M1PF88	Streptococcus_phage	3.3e-11	49.4
WP_016481379.1\|2063933_2064128_-	hypothetical protein	NA	NA	NA	NA
WP_016481380.1\|2064124_2064613_-	hypothetical protein	A0A1X9I5T7	Streptococcus_phage	3.1e-45	61.3
WP_016481381.1\|2064617_2064767_-	hypothetical protein	NA	NA	NA	NA
WP_016481382.1\|2064838_2064994_-	hypothetical protein	NA	NA	NA	NA
WP_016481383.1\|2065495_2065684_-	helix-turn-helix transcriptional regulator	A0A141E205	Streptococcus_phage	1.2e-05	42.6
WP_016481384.1\|2065873_2066494_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_041165786.1\|2066930_2068097_+\|integrase	site-specific integrase	A0A1X9I5Y5	Streptococcus_phage	2.1e-169	76.0
2070804:2070820	attR	NA	NA	NA	NA

DBSCAN-SWA_8

2079107 : 2086311

uncultured_Caudovirales_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001042662.1\|2079107_2079812_-	transglycosylase SLT domain-containing protein	A0A2H4J6C5	uncultured_Caudovirales_phage	6.4e-28	65.3
WP_000029067.1\|2079917_2080457_-	LysM peptidoglycan-binding domain-containing protein	A0A249XZV3	Enterococcus_phage	3.0e-17	46.4
WP_016481391.1\|2080672_2081467_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000510606.1\|2081459_2082302_-	energy-coupling factor transporter ATPase	A0A2H4PQG7	Staphylococcus_phage	2.0e-15	28.5
WP_000181757.1\|2082277_2083117_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	3.5e-20	30.0
WP_000976003.1\|2083116_2083659_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_016481393.1\|2083781_2085065_-	insulinase family protein	A0A2H4UVM3	Bodo_saltans_virus	4.8e-05	22.8
WP_016481394.1\|2085066_2086311_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	8.3e-87	41.1

Anti-CRISPR protein detection

Acr_ID: NC_021486.1|WP_016481361.1|2051427_2052009_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NC_021486.1|WP_001104152.1|671285_671444_-|hypothetical-protein

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Acr_ID: NC_021486.1|WP_001113676.1|671803_671947_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_021486.1|WP_016481361.1|2051427_2052009_-|hypothetical-protein

2051427_2052009_-

193 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|89	0.45549738219895286	0.9792746113989638	0.9792746113989638

NC_021486.1|WP_001104152.1|671285_671444_-|hypothetical-protein

671285_671444_-

52 aa aa

615037-699737

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_021486_1	TypeI	1.5\|475829\|35\|NC_021486\|CRISPRCasFinder,CRT	475829-475863	35	629004-628970	0
NC_021486_2	TypeII-A	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	662363-662392	1

1. spacer 1.5|475829|35|NC_021486|CRISPRCasFinder,CRT matches to NC_021486 position: 629004-628970, mismatch: 0

tcccagtccaatgttttattagccatctcagcctc	CRISPR spacer
tcccagtccaatgttttattagccatctcagcctc	Protospacer
***********************************

2. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to NC_021486 position: 662363-662392, mismatch: 1

ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ctagtcaaatattgcaagagattagtgaca	Protospacer
********** *******************

NC_021486.1|WP_001113676.1|671803_671947_-|hypothetical-protein

671803_671947_-

47 aa aa

615037-699737

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_021486_1	TypeI	1.5\|475829\|35\|NC_021486\|CRISPRCasFinder,CRT	475829-475863	35	629004-628970	0
NC_021486_2	TypeII-A	2.1\|933674\|30\|NC_021486\|CRISPRCasFinder,CRT	933674-933703	30	662363-662392	1

1. spacer 1.5|475829|35|NC_021486|CRISPRCasFinder,CRT matches to NC_021486 position: 629004-628970, mismatch: 0

tcccagtccaatgttttattagccatctcagcctc	CRISPR spacer
tcccagtccaatgttttattagccatctcagcctc	Protospacer
***********************************

2. spacer 2.1|933674|30|NC_021486|CRISPRCasFinder,CRT matches to NC_021486 position: 662363-662392, mismatch: 1

ctagtcaaatcttgcaagagattagtgaca	CRISPR spacer
ctagtcaaatattgcaagagattagtgaca	Protospacer
********** *******************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_021486

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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