CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021738	Mannheimia haemolytica D171, complete sequence	3 crisprs	DEDDh,cas2,cas1,cas4,cas7,cas8c,cas5,cas3,PD-DExK,WYL	1	5	4	2

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_021738_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021738_1

8737-8811

Orphan

Consensus_repeat	Method
TTCTGGTGTCTGCCACCGCTAGG	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NC_021738_1

>merge|NC_021738|1|8737-8811|CRISPRCasFinder
TTCTGGTGTCTGCCACCGCTAGGTCTTTATACCCTAGATTAGTATCAGGTCTTTCTGGTGCCTGCCACCGCTAGG

>NC_021738|1|1|8737-8811|CRISPRCasFinder
TTCTGGTGTCTGCCACCGCTAGG	TCTTTATACCCTAGATTAGTATCAGGTCT
TTCTGGTGCCTGCCACCGCTAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_021738.1\|WP_006253491.1\|11171_11687_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|136097
NC_021738.1\|WP_020824043.1\|2193_6390_-\|autotransporter-domain-containing-protein	unknown	unknown	gnl\|CDD\|367071
NC_021738.1\|WP_006250506.1\|18958_20884_+\|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|224120
NC_021738.1\|WP_006250186.1\|20957_21323_+\|CidA/LrgA-family-protein	unknown	unknown	gnl\|CDD\|234983
NC_021738.1\|WP_006250509.1\|17670_18468_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224026
NC_021738.1\|WP_006253136.1\|16736_17669_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226605
NC_021738.1\|WP_020824046.1\|11841_14670_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_021738.1\|WP_006248320.1\|689_959_-\|DUF1040-family-protein	unknown	unknown	gnl\|CDD\|368826
NC_021738.1\|WP_006250508.1\|18554_18776_+\|hypothetical-protein	unknown	unknown	unknown
NC_021738.1\|WP_006253266.1\|10168_10468_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|213767
NC_021738.1\|WP_020824044.1\|7499_8540_+\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|366234
NC_021738.1\|WP_006249416.1\|14761_16495_-\|C4-dicarboxylic-acid-transporter-DauA	unknown	unknown	gnl\|CDD\|183265
NC_021738.1\|WP_006250514.1\|8927_10169_-\|HipA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377920

Protein	Function_ID	Function_description	E-value
NC_021738.1\|WP_006253491.1\|11171_11687_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|136097	PRK06863, PRK06863, single-stranded DNA-binding protein; Provisional.	2.51083e-99
NC_021738.1\|WP_006250506.1\|18958_20884_+\|ATP-dependent-DNA-helicase	gnl\|CDD\|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	0
NC_021738.1\|WP_006250186.1\|20957_21323_+\|CidA/LrgA-family-protein	gnl\|CDD\|234983	PRK01821, PRK01821, hypothetical protein; Provisional.	3.61345e-25
NC_021738.1\|WP_006250509.1\|17670_18468_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224026	COG1101, PhnK, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	2.67049e-138
NC_021738.1\|WP_006253136.1\|16736_17669_+\|ABC-transporter-permease	gnl\|CDD\|226605	COG4120, COG4120, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.63801e-98
NC_021738.1\|WP_020824046.1\|11841_14670_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_021738.1\|WP_006248320.1\|689_959_-\|DUF1040-family-protein	gnl\|CDD\|368826	pfam06288, DUF1040, Protein of unknown function (DUF1040). This family consists of several bacterial YihD proteins of unknown function.	8.73032e-44
NC_021738.1\|WP_020824043.1\|2193_6390_-\|autotransporter-domain-containing-protein	gnl\|CDD\|367071	pfam02395, Peptidase_S6, Immunoglobulin A1 protease. This family consists of immunoglobulin A1 protease proteins. The immunoglobulin A1 protease cleaves immunoglobulin IgA and is found in pathogenic bacteria such as Neisseria gonorrhoeae. Not all of the members of this family are IgA proteases, EspP from E. coli O157:H7 cleaves human coagulation factor V and hbp is a hemoglobin protease from E. coli EB1.	0
NC_021738.1\|WP_006253266.1\|10168_10468_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	1.78571e-05
NC_021738.1\|WP_020824044.1\|7499_8540_+\|IS481-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.23372e-24
NC_021738.1\|WP_006249416.1\|14761_16495_-\|C4-dicarboxylic-acid-transporter-DauA	gnl\|CDD\|183265	PRK11660, PRK11660, putative transporter; Provisional.	0
NC_021738.1\|WP_006250514.1\|8927_10169_-\|HipA-domain-containing-protein	gnl\|CDD\|377920	pfam07804, HipA_C, HipA-like C-terminal domain. The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.	5.96698e-62

>NC_021738.1|WP_020824044.1|7499_8540_+|IS481-family-transposase
MFYSNNPLIKHKTGLLNLAEELGNISQACKVMGMSRDTFYRYQQAVEQGGVEALLNQNRRVPNLKNRVDEAIEQAVVKFALDNPAFGQVRVSNELRKQGIFVSAGGVRSIWLRHHLANFKQRLIALEKLVAEQGIILSETQVQALERKKEDEIACGEIETTHPGYLGSQDTFYVGNLKGVGRIYQQTFIDTYSKVAFAKLYTMKTAISAADMLNDKVLPYFESQGLPMLRILTDRGSEYCGKVENHDYELYLAINDIEHSKTKVKHPQTNGICERFHKTILQEFYQVAFRKKIYTDLTTLQADLDEWLMYYNHHRTHQGKMCCGRTPMATLLDGKRIWVEKNLSSN
>NC_021738.1|WP_020824043.1|2193_6390_-|autotransporter-domain-containing-protein
MKTKTFTRSYLASFVTIVLSLPAVASVVRNDVDYQYFRDFAENKGPFSVGSMNIDIKDNNGQLVGTMLHNLPMVDFSAMVRGGYSTLIAPQYLVSVAHNTGYKNVQFGAAGYNPDSHHYTYKIVDRNDYEKVQGGLHPDYHTPRLNKLVTEVVPAAVTNAGTSIKPYLNEERFPMFLRAGSGTQALRGKESNKTTGIAGAYEYLTGGTTLQLSKSSPDHWLDYSSNLYQVSYGPLSTYALPGDSGSGSYAYDMNEKRWVLVGVLNFYNGMDNQFNRSAIIRKDFHEKKFAEDIAGTINNTVQNAQFNWTAQGKSSSLSQSNNVQKLNVDLKDSSIANQNTSLPQENHGKTINFNGKDATIVLKQDIDQGAGALNLNANLTIRPETDQTWQGAGIIVGKDKKVNWQVKNPQGDRLSKLGEGTLYVNGRGQNLGDISVGDGIVILNQQADHQGRKQAFNTVGIVSGRPTVVLGSTDQVNPDNIYFGFRGGRLDLNGNSIAFKRIQNSDKHARIVNHNRDHISTLIIQGQDPLTSNDLIWGKWASNSPADIYEYTNPYQNKRKDYFRLKGNSRVYYPTNATSNDHWEFLSSNREQAIQKILDAKNLRQRYDTFNGFIGEDASNKTNGILNVVFDTKTEVNTEQDKLKNIYTMSGGFNLNGELTLKGGTLLLSGHPTPHAYDIKNKHDVVRENDWQDSHFTAKNITVNKMAQLYIGRNVNEVNSHFTATDKAKLNLGFINRSTPSCYDSEYTGTTHCEVQAVISDNIFANLATTAIKGNVKLQNHSQLNLGKANLTGSVQADQTTHITLANHSHWLNNGTSQIGHLTMEKGSILSLNDKFATTEIPVRFNKMIIQGNLKGNGRINYTANLAKGESDHLQVDGIAEGNFVLAVRNSTTEANPKSSLNLLSLKNSNQEGNKVSISLENNYVDLGTYRYVLENRNHNYHLFNPLIPNSTSKEMNATSVSSIPKKESVTNVPTLDKKETEQNLTQLQKDFSAHQLENQKAKQSMINAQSELRRLNSQLNVLQKYVNSRRLGYYTQQAVLEQISIIQNKIKQTQTIFNDANATVKLTDQKLEEAKLALGSVNDLVLIKASAPAMQATNQDTSMMNIIQADWISQYANTALSELSAQANSALQISNSLDRQLFKQSDKFNVWSSVEHQKTEHKSDLYRPYKQQTNLTQLGIQMPIDNGLMFGVALSKNHANAEFNEGVNGKSNLLMASLYGKWQSQQGTFISLDGSYGKAKNQLYLFGENHFTRRISSIGANIGHQFDLAGVQIQPTIGARYYHFSGQDYTLGGAKISSPNTHFMTYQAGLKASKTFSLDDWKVEPSITTHYVDASNKRLAVNVNNNNINQRFGRYLKTEAGIRFEHNQWQFDLHAGFINGNEIKKQHFAGVKLGYSW
>NC_021738.1|WP_006248320.1|689_959_-|DUF1040-family-protein
MKCERLEELLELLGEHWRKNPDLHLIDILQQLSVEVGEPDNFKALSDEVLIYQLKMRNAGKFEPIPGIKKDYEDDFKTALLRARGILND
>NC_021738.1|WP_006250514.1|8927_10169_-|HipA-domain-containing-protein
MMNKRIYVFADWETFSQPELVGVLSSDVVRGKENFRFSYDNEWLSSPYVQQIDPNLYLYPGEQYSTDTQNFHIFLDSCPDRWGRLLMKRREAALASQENRKPKLLIESDYLLGVHDMNRMGALRFKTELNGPFLDNNTRLAAPPLSSLRELEFAAIQLESSDNVDDPDYLKWLHMLISPGSSLGGARPKASVIDELNQLWIAKFPSRYDDYDIALWEYLAYRLAIQAKIEMATCRIERFNQEHHTFLTQRFDRHCGKRRHFTSALTQLGYYDGDYEASYLEIAQFLTESGSNTRIDLAQLWRRIVFNIAISNTDDHLRNHGFIYAQEGWILSPAYDLNPVPLSQGLHLNITDSDNRLDYQLAFDVADFFQLSKQQAVQIYDEVLKEVNNWQNVAKEIGIPRQEQEQMKFAFNV
>NC_021738.1|WP_006253266.1|10168_10468_-|helix-turn-helix-domain-containing-protein
MLSKTKSPTLFPKYQNALLQLGENIRLASKRRMFTQTLLAQRTGLSRVTVRKIMNGDPTVAIGYYLMVLGVLGLEQDFTDVGKDDELGRKLQDIELLRK
>NC_021738.1|WP_006253491.1|11171_11687_-|single-stranded-DNA-binding-protein
MAGINKVIIVGNLGNDPEMRTMPNGEAVANISVATSESWTDKNTGERREVTEWHRIVFYRRQAEVCGQYLRKGSQVYVEGRLKTRKWQDQNGQDRYTTEIQGDVLQMLGSRQGNDMGGQQGGWGNSAPAGNSYNQGNSNYGYNQTQSAAPQSKPAPQPEPAMNNFDDDIPF
>NC_021738.1|WP_020824046.1|11841_14670_+|excinuclease-ABC-subunit-UvrA
MQHIDIRGARTHNLKNINLTLPRDKFIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTVTEIHDYLRLLFARVGEPRCPDHDVPLAAQTISQMVDRVLEEPEGKRMMLLAPVVKERKGEHVKLLENLTASGYLRARIDGEICDLSDPPALELQKKHTIEVVVDRFKVRADLATRLAESFETALDLSGSTAIIADMDDPNAEEIVFSSSFACPHCGYSLHELEPRLFSFNNPAGACPTCDGLGVEQFFDAKKVVQNEEVSLAAGAIKGWDRRSFYYFGLLKAVAEHYGFDLETPFGQLPKKYQNIILNGTKEEIEFVYVNDRGDKVKRKHAFEGVLNNMARRYKETESNAVREELAKYINNRPCMDCEGSRLRREARYVFLDKTNLPMVSEKSIGEALTFFEELKLAGQKEKIAEKILKEIRERLQFLVNVGLNYLSLSRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLNTLVHLRNLGNTVIVVEHDEDAIRAADHIVDIGPGAGVHGGQVIAQGTAAEIMQIEESITGQFLSGKQKIEIPAQRVPYEPTKLLTLSGASGNNLKKVKLEIPVGLFTCITGVSGSGKSTLVNDTLFLLAQNALNRAENSDVAPYESIDGLSHFDKVIDIDQSPIGRTPRSNPATYTGLFTPIRELFAGTQEARARGYNVGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDHCKGKRYNRETLEIRYKGKTIHQVLEMTVEEAREFFAPVPMIARKLQTLMDVGLSYIRLGQSSTTLSGGEAQRVKLATELSKRDTGKTLYILDEPTTGLHFADIKQLLGVLHRLRDQGNTIVVIEHNLDVIKTADWIVDLGPEGGSGGGEIIATGTPEEVAKDKRSHTARFLKEILAKG
>NC_021738.1|WP_006249416.1|14761_16495_-|C4-dicarboxylic-acid-transporter-DauA
MLNKWFLTKNAFLAVKPFSALKDALNAGYGKQHLIRDIISGLTVGVIAIPLSMALAIASGVPPQHGLYTAIVAGIVIALTGGSRFNISGPTAAFVVILYPVTQQFGLSGLLMATMLSGGILVLMALLRLGRLIEYIPLPVTLGFTCGIGIVIATLQIKDFLGLSIEKMPEHYLGKLEAIFSALPTINWADTLVGVVTLLVLTRWHKLRLPIPGHLPAVFIGTLLSLLLIHFGQNVATIGSAFHYTLSDGTTGYGIPSVLPEFVLPWNLPNAEGNRIDWNLTTIQALLPAAFSMAMLGAIESLLCAVVCDNMTDTKHHSNNELLAQGLGNIASPFLGGITATAAIARSAANVRSGAVSPISSVVHALLVLFALLFLAKALSYLPLSSMAALLLVVAWNMADIPQIIQLTRRSGKNEIAVLLTCITLTVLFDMVIAITVGVLLASLLFIRTIAEMTKSFEMAHPTDLNDVLVYRISGPLFFAAADNLFADLHNKTVHTDHQIKHIVLQCDAVTVLDAGGIHALTRFVQHMLPHQQLHLCNVQFQPMRMLVRSQKTVNEIPQIQFSSDLESAFDKIRQAN
>NC_021738.1|WP_006253136.1|16736_17669_+|ABC-transporter-permease
MDSLIHFLSAFLTNITWIGALELGLIYSLVALGVLISYKILDFPDLTADGSFPLGGAVCVISILNQVDPWLATLYGTLAGAVAGMVTASLHIGFKIEKLLASILMMIALYSINLRIMGMPNIAILGETTIYDVMPIESDLQLALVRLVMTLLVVIIVKGLFDLFFATEIGLAVRATGTNSRMAKAQGIAINKMTILGMAISNALIALGGALYVQSNGGVDISIGVGTIVIGLAAVIIGEAIFSVKRIIWLTFAVIIGSILYRFFIALALNNETLNGIGFGPQDLNLITALLVVIVLVVPRIKHKLLGKRG
>NC_021738.1|WP_006250509.1|17670_18468_+|ABC-transporter-ATP-binding-protein
MIELNNLFITFNKGTAIENPVLRGLSLKVEQGEFVSVIGSNGAGKSTLLNAISGDCAVDSGEILIQGNKVNQSTTWQRANQVARVFQDPMAGTCESLTIEENMALAYQRGRKRGLGFAIKRQMRELFKDKLALLGLGLENRLTDQMGRLSGGQRQAVSLLMASLQPSNVLLLDEHTAALDPKTTDFVLELTNKIVREQKLTTLMVTHSMRQALDYGDRTVMLHQGQVAFDVSGEQRQKMDVPDLLQLFQQSRHEQLSDDGLLLGN
>NC_021738.1|WP_006250508.1|18554_18776_+|hypothetical-protein
MLSIFKTPVEKETLDDWAKISVDVAKVAILAIPVILFGKEPTLIKLTNLALLVLSIYVFLTLGRKLRQLKEVL
>NC_021738.1|WP_006250506.1|18958_20884_+|ATP-dependent-DNA-helicase
MTKYDDKIQHAFSENGLLSQNISGFRPRQAQLEMAQVVAKAVKFATPVVVEAGTGTGKTFAYLVPALLSGKKTILSTGSKNLQDQLFNRDLPTIQKALKYKGKIALLKGRANYLCLERLDQVTAMGVLGDKSVLTDLKKVSKWQNATKTGDLSECITIAEDSPILPQLVSTTESCLGSDCPHFKDCYVVQARRKAMEADVVVVNHHLFCADMAVKETGFGELIPEAELVIFDEAHQLPDIASQYFGQSLSSRQLFDICKDTNIVYRTELKDLSQLGKAADHLTKVVQDFRLLMGGEGQIRGNLRELFRDKKVVDGLVKVAENIDFLSEVAKKSLGRSEMLDKIFERLAEVKVQLKKLMDTSVTGYCYWYEANGRSFGLHITPLMVADKFGEQLKNQQIGWVFTSATLEVGGKFDHFCQRLGIENAEQLVLQSPFDYQHQSLLCVPRYLPDTNKSNTLTALGQLLKPVIEANKGRCFLLCTSYYMMRGLADFLREHSSLNVLLQGETSKSRLLEKFVKEDHSVLVATQSFWEGIDVRGDDLSLVIIDKLPFTSPDEPLLKARMEDCKIQGGDPFNDIQIPEAVITLKQGVGRLIRDVTDRGVVIICDSRLVMRNYGQTFLKSLPPSRRTRDLGNVIQFLKQK
>NC_021738.1|WP_006250186.1|20957_21323_+|CidA/LrgA-family-protein
MLSTLLRMVASLALLFVMLYLGKLIVYLFPIGIPDSILGMLILFGCLVIGIVKVEWVIPSAKPLTRYITLFFLPICVELIEHLELLRQNLNTFVLATALSTLVSVVAIGVFAQWIFHYKRG

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Crispr_ID: NC_021738_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021738_2

433673-433970

TypeI

Consensus_repeat	Method
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	CRISPRCasFinder
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	CRT
GGTGTTTCAATTCACAGCCACGCGTAGGTGGCTGC	PILER-CR

4 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NC_021738_2

>merge|NC_021738|2|433673-433970|CRISPRCasFinder,CRT,PILER-CR
GTTTCAATACACAGCCACGCGTAGGTGGCTGCAATTGCCTGTACATCAACATAACCACAAACACGGAGTTTCAATTCACAGCCACGCGTAGGTGGCTGCTCGAAAATCTTCCACGCATTTACGCCGATGTCAGTGTTTCAATTCACAGCCACGCGTAGGTGGCTGCAGGGTGAGAGCCTAGAGCTTTACCGCAAGCGGGTGTTTCAATTCACAGCCACGCGTAGGTGGCTGCTAATCCCCTTGCCTACCATCTCGGAGGAGGTGGTGTTTCAATTCACAGCCACGCGTAGGTGGCTGC

>NC_021738|2|2|433673-433970|CRISPRCasFinder
GTTTCAATACACAGCCACGCGTAGGTGGCTGC	AATTGCCTGTACATCAACATAACCACAAACACGGA
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TCGAAAATCTTCCACGCATTTACGCCGATGTCAGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	AGGGTGAGAGCCTAGAGCTTTACCGCAAGCGGGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TAATCCCCTTGCCTACCATCTCGGAGGAGGTGGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC

>NC_021738|2|1|433673-433970|CRT
GTTTCAATACACAGCCACGCGTAGGTGGCTGC	AATTGCCTGTACATCAACATAACCACAAACACGGA
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TCGAAAATCTTCCACGCATTTACGCCGATGTCAGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	AGGGTGAGAGCCTAGAGCTTTACCGCAAGCGGGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TAATCCCCTTGCCTACCATCTCGGAGGAGGTGGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC

>NC_021738|2|1|433737-433970|PILER-CR
GGAGTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TCGAAAATCTTCCACGCATTTACGCCGATGTC
AGTGTTTCAATTCACAGCCACGCGTAGGTGGCTGC	AGGGTGAGAGCCTAGAGCTTTACCGCAAGCG
GGTGTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TAATCCCCTTGCCTACCATCTCGGAGGAGGT
GGTGTTTCAATTCACAGCCACGCGTAGGTGGCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021738.1\|WP_006250670.1\|437970_439755_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|187887
NC_021738.1\|WP_006250678.1\|426833_427244_+\|H-NS-histone-family-protein	unknown	unknown	gnl\|CDD\|182380
NC_021738.1\|WP_006250681.1\|422685_423876_-\|tryptophan-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|235288
NC_021738.1\|WP_020824140.1\|442407_443463_-\|SIR2-family-protein	unknown	unknown	gnl\|CDD\|238697
NC_021738.1\|WP_006248118.1\|431947_433423_-\|ribonuclease-G	unknown	unknown	gnl\|CDD\|183285
NC_021738.1\|WP_006248815.1\|427313_428153_+\|formyltetrahydrofolate-deformylase	unknown	unknown	gnl\|CDD\|235676
NC_021738.1\|WP_006250680.1\|423887_424640_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187604
NC_021738.1\|WP_006248107.1\|439751_440429_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NC_021738.1\|WP_006250679.1\|424865_426398_-\|Na+/H+-antiporter-NhaC-family-protein	unknown	unknown	gnl\|CDD\|224671
NC_021738.1\|WP_006250667.1\|443593_445882_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NC_021738.1\|WP_006250674.1\|434519_435533_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NC_021738.1\|WP_020824138.1\|421877_422684_-\|tryptophan-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|161792
NC_021738.1\|WP_006250672.1\|436432_437098_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NC_021738.1\|WP_006250677.1\|428189_428873_-\|YdcF-family-protein	unknown	unknown	gnl\|CDD\|225500
NC_021738.1\|WP_006248114.1\|434159_434453_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_021738.1\|WP_006250676.1\|430291_431794_-\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NC_021738.1\|WP_006250673.1\|435650_436331_+\|hypothetical-protein	unknown	unknown	unknown
NC_021738.1\|WP_006250669.1\|440666_442418_-\|DUF87-domain-containing-protein	unknown	unknown	gnl\|CDD\|223510
NC_021738.1\|WP_006250671.1\|437097_437961_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NC_021738.1\|WP_006248812.1\|429140_430214_+\|homoserine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|234678

Protein	Function_ID	Function_description	E-value
NC_021738.1\|WP_006250670.1\|437970_439755_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	0
NC_021738.1\|WP_006250678.1\|426833_427244_+\|H-NS-histone-family-protein	gnl\|CDD\|182380	PRK10328, PRK10328, DNA-binding protein StpA.	1.90925e-33
NC_021738.1\|WP_006250681.1\|422685_423876_-\|tryptophan-synthase-subunit-beta	gnl\|CDD\|235288	PRK04346, PRK04346, tryptophan synthase subunit beta; Validated.	0
NC_021738.1\|WP_020824140.1\|442407_443463_-\|SIR2-family-protein	gnl\|CDD\|238697	cd01406, SIR2-like, Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.	1.63776e-08
NC_021738.1\|WP_006248118.1\|431947_433423_-\|ribonuclease-G	gnl\|CDD\|183285	PRK11712, PRK11712, ribonuclease G; Provisional.	0
NC_021738.1\|WP_006248815.1\|427313_428153_+\|formyltetrahydrofolate-deformylase	gnl\|CDD\|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	2.87146e-173
NC_021738.1\|WP_006250680.1\|423887_424640_-\|SDR-family-oxidoreductase	gnl\|CDD\|187604	cd05346, SDR_c5, classical (c) SDR, subgroup 5. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.41499e-146
NC_021738.1\|WP_006248107.1\|439751_440429_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	2.38632e-113
NC_021738.1\|WP_006250679.1\|424865_426398_-\|Na+/H+-antiporter-NhaC-family-protein	gnl\|CDD\|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	4.15788e-96
NC_021738.1\|WP_006250667.1\|443593_445882_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	4.9519e-57
NC_021738.1\|WP_006250674.1\|434519_435533_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NC_021738.1\|WP_020824138.1\|421877_422684_-\|tryptophan-synthase-subunit-alpha	gnl\|CDD\|161792	TIGR00262, Tryptophan_synthase_alpha_chain, tryptophan synthase, alpha subunit. Tryptophan synthase catalyzes the last step in the biosynthesis of tryptophan. The alpha chain is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. In bacteria and plants each domain is found on a separate subunit (alpha and beta chains), while in fungi the two domains are fused together on a single multifunctional protein. The signature pattern for trpA contains three conserved acidic residues. [LIVM]-E-[LIVM]-G-x(2)-[FYC]-[ST]-[DE]-[PA]-[LIVMY]-[AGLI]-[DE]-G and this is located between residues 43-58 of the model. The Sulfolobus solfataricus trpA is known to be quite divergent from other known trpA sequences. [Amino acid biosynthesis, Aromatic amino acid family].	2.62732e-123
NC_021738.1\|WP_006250672.1\|436432_437098_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	5.92936e-41
NC_021738.1\|WP_006250677.1\|428189_428873_-\|YdcF-family-protein	gnl\|CDD\|225500	COG2949, SanA, Uncharacterized membrane protein [Function unknown].	3.48782e-75
NC_021738.1\|WP_006248114.1\|434159_434453_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	8.20021e-33
NC_021738.1\|WP_006250676.1\|430291_431794_-\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NC_021738.1\|WP_006250669.1\|440666_442418_-\|DUF87-domain-containing-protein	gnl\|CDD\|223510	COG0433, COG0433, HerA helicase [Replication, recombination, and repair].	3.53798e-29
NC_021738.1\|WP_006250671.1\|437097_437961_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	6.00618e-155
NC_021738.1\|WP_006248812.1\|429140_430214_+\|homoserine-O-acetyltransferase	gnl\|CDD\|234678	PRK00175, metX, homoserine O-acetyltransferase; Provisional.	0

>NC_021738.1|WP_006248118.1|431947_433423_-|ribonuclease-G
MSSTELLVNVTPSETRVALVENGILKELHIEREAKRGIVGNIYKGRVTRVLPGMQSAFVDIGLEKAAFLHASDIVSHTECVDENEKKQFLVKDISELVREGQDIVVQVVKDPIGTKGARLTTDITLPSRYLVFMPENSHVGVSQRIESEEERARLKSLVEPYCDELGGFIVRTAAEEATEESLKQDVEFLKRLWRKVLERKGKYSAKSMLYGELALAQRVLRDFIGTHINSVRIDSKLTYEQVREFLAEFMPELTDCVTLYTGQQTLFDAYGVEKAIQKALDKRVDLKSGGYLIIEQTEAMTTIDINTGAFVGHRNLAHTIFNTNIEAIQAIAHQLQLRNLGGIIIIDFIDMQEEEHRERVLQSLQEALKGDRVKTNVNGFTQLGLVEMTRKRTRESLERILCCDCQACQGRGTVKTVETVCYEIMREIVRVHHLFKTENIHVYAAKDVAEYLINEESHALLAELQAFIGKKIEIKLEPYYHQEQFDVVVM
>NC_021738.1|WP_006250676.1|430291_431794_-|lysine--tRNA-ligase
MSEVENQELDLNGEMLARREKLNKIREQGNAFPNTFRRDALAKDLHAQYDAVEGETLKEQNIQVKVAGRIMLKRVMGKASFFTIQDVSGAIQLYVARDNLSDSVYEEKVSLWDLGDIVGVEGALFKTKTGELTVRCSEVQLLTKSLRPLPDKHHGLTDLETRYRQRYLDLISNEESRRTFMIRSQVVSGIRKFFLERDFIEVETPMLQVIPGGAAAKPFITHHNALDVDMYLRIAPELYLKRLVVGGFERVFELNRNFRNEGVSVRHNPEFTMIEYYQAYADYHDLMDNTEELLRQLALDILGTTDVPYGDYVFDFGKPFERITMHDAIVKYGNGIQREDLDSFEKSVEIAKGLGIEIQKSWGLGSVVNAIFEEVAEHQLIQPTFLMAHPAEISPLARRNDENPEVTDRFELFIGGREIGNGFSELNDAEDQAERFDAQVAAKDAGDDEAMFKDEDFIVALEHGLPPTAGEGLGIDRLAMIFANAPSIRDVILFPAMRQK
>NC_021738.1|WP_006248812.1|429140_430214_+|homoserine-O-acetyltransferase
MAQQITLFEDVPLPLTLGGELSPITVAYQTYGRLNAEKSNAVLLCHALTGDAKPYYDSPTEKGWWQDFIGKGLAFDTDKYFFICSNVLGGCKGTTGPASINPKTNKPYGSLFPIITVQDIVNVQKALLDYLEIPQLHAVVGGSFGGMQATQWGISYPDKVRNIINLCSSLTLSAEAIGFNHVMRQAIINDPHFNGGNYYDGIAPDNGLKIARMLGMLTYRTDIQLAKAFGRETKQQGQIWGDHFQVESYLSYQGTKFLGRFDANTYLRLLRALDLYDPALGYENEETALKRIKANYTFVAVTSDQLFKQVDVYKSKQKLEQAGVNLEFHEFHSDFGHDAFLVDYDFFEPMIKAGLAK
>NC_021738.1|WP_006250677.1|428189_428873_-|YdcF-family-protein
MNQTRDRLEKLPLFHKMQQFIIKALKIIAIFPLLGIAILLLVDSLTSYIVRDKIYTDSKQIPYREYAVVLGTAKFYSKDVINQYYKYRLEAAKQLVQEGKVNQLLLSGDNKTPYYNEPKTMTSDLLKMGIATSKIKQDYAGYTTFDSIIRAKKVYKLPPFTIISQKFHCERALFIAKFRDIDAICYAATYPEGAYQVRMREILARSAMVFSLLIGKEPESLEDIRSK
>NC_021738.1|WP_006248815.1|427313_428153_+|formyltetrahydrofolate-deformylase
MLQQHKILLTECPDDTGLVAKITNICYKHQLNIIKNSEFVENETKRFFMRTELNGIFNDETLLTDLKFTLPEGSSYKLLPKQRKRIVILVTKEAHCLGDLLMKNYYGGLDVEIAAVIGNHETLKSLVERFDIPFHLVSHENLTRVEHDKLLAEKIDEYSPDYIVLAKYMRVLNPEFVARYPNRVVNIHHSFLPAFIGAKPYHRAYERGVKIIGATAHFVNDELDEGPIIMQNVINVDHTYTAEAMMRAGRDVEKTVLSQALELVLADKVFVYKNKTIIL
>NC_021738.1|WP_006250678.1|426833_427244_+|H-NS-histone-family-protein
MSALKSLLNIRSLRALAKDLALEQLKSISEKLDIIIAEKEEEMKQEELEKLKQLESLNKYREMLKQDGLSIDELAELLADKVIKTRKARKALSPRPAKYKFVDANGNEKTWTGQGRTPKALQDALDSGKKLEDFAI
>NC_021738.1|WP_006250679.1|424865_426398_-|Na+/H+-antiporter-NhaC-family-protein
MNLVDYSTSLWSVLPALIALILAIVTRKVIISLSIGILFGAFMLTNSNFLDALTYIKNSVVSLVYKGAEEGLNSNNVNIILFLLLLGVLTSLLSISGSNQAFANWAQKKVKGKRGAKLMAAGLVFFTFIDDYFHSLAVGAIARPVTDKFRVSRAKLAYILDSTAAPMCVLMPISSWGAYIITLIAGLLATHSITGYSPLGAFMTMSAMNFYAIFAMIMVFFVAYFSFDIGSMARFERQAAHLAELDDEQIETKGHVRDLILPIIALIVATVSMMMKTGADALAESGASFSILGAFENTTVGISLVVGGVAGLIVATICIITSGNISFKNYVRAYGLGVKMMSGAITILFFAWTINGVVSDMQTGKYLSGLVAESIGAEFLPAILFVLAAAMAFSTGTSWGTFGIMLPIGASMAVHSDPALIIPCLSAVMAGAVCGDHCSPVSDTTILSSTGAQCNHMDHVISQLPYALLVATASIVGYLVVGFTQSAVLGFIATAIVMAILILLFKEKKH
>NC_021738.1|WP_006250680.1|423887_424640_-|SDR-family-oxidoreductase
MKIALVTGVTAGFGLAICKLLLQSGYKVIGTGRRAERLEELHLQFGDKFLPLAFDIQQPDEVEKALNSRPKAWQQIDLLVNNAGLALGLEPAQKADLNDWYQMIDTNIKGLVTMTRLVLPEMVERNSGHIINIGSIAGTYPYPGGNVYGGTKAFVKQFSLNLRADLAGTKVRVSNVEPGLCGGTEFSNVRFKGDDEKAAKVYENVQFVRPEDVANIVLWLNQQPEHVNINRVEVMPVAQTSSALNVARNI
>NC_021738.1|WP_006250681.1|422685_423876_-|tryptophan-synthase-subunit-beta
MSDTLLNPYFGEFGGMYVPEILVPVLKELEQAFVDAQQDPTFQAEFADLLKNYAGRPTALTLCRNLTKGSKTKLYLKREDLLHGGAHKTNQVLGQILLAKRMGKTRIIAETGAGQHGVATALACAMLGMPCVVYMGAKDVERQSPNVFRMRLMGAEVIPVQKGSCSLKDACCEAMRDWAANYDTTHYLIGTAAGPHPFPTMVREFQKMIGEETKRQILAKEDRLPDAVIAAVGGGSNAIGMFADFIEEQSVKLIGVEPAGKGIETGEHGAPLKHGTTGIYFGMKSPIMQDKDGQIEESYSISAGLDFPSVGPQHAYLNATGRAEYVSITDAEALEAFQALAKNEGIIPALESSHALAYALKMIKQNPEKEQLLVVNLSGRGDKDIFTVDKILNGGE
>NC_021738.1|WP_020824138.1|421877_422684_-|tryptophan-synthase-subunit-alpha
MSRFDTLFTALKAKNEGAFVPFVTLCDPGFERSFEIIDTMIKNGADALELGFPFSDPLLDGPVIQAANKRALDGGYSTDSCFELIAKIRAKYPDIPIGLLLCANLIFVPIAEVFFQRCQQSGVDAVLIADLPVFAAQEFVPTAEKYGIQPVFICPPNADQNTIERIAQLTQGYTYLVSRAGVTSAENQAHASNLDNLVESLKQTGAAPILQGFGIAKPEQVKEALRLGADGAISGSAIVKIIERNLSNQANLLKELAEFVQVMKAATK
>NC_021738.1|WP_006248114.1|434159_434453_-|CRISPR-associated-endonuclease-Cas2
MLMLITYDISFDDPEGQARLRRIAKHCLDYGVRAQYSVFECDVTPAQWVTLKNKLLATYNPDCDSLRFYHLGSKWRNKVEHHGAKPSVDIFKDTLIL
>NC_021738.1|WP_006250674.1|434519_435533_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MRKLQNTLYITSQGSYLHKERETLVVEQDRKKVAQLPIHSIGHIFCFGNVLVSPFLMGFCGENNVNLAFFTENGRYLGRLQGRQSGNVLLRRAQYKKSETNPVPVARNIIAAKIQASKRVLQRQIRNHGENADIQLAITALNYSLQQLKIADNLNLIRGIEGDAAARYFGMFSHLIKENSGFHFDGRNRRPPRDGVNALLSFLYSILGKDISGALQGVGLDPQIGFLHADRPGRDSLAQDILEEFRAWWVDRMVLSLINRGQVKPDDFVTEASGAVTLKPEARKLLFQTLQAKKQEKIIHPFLEEEVEIGLLPYIQAMLLARHLRGDLAEYPPFLMR
>NC_021738.1|WP_006250673.1|435650_436331_+|hypothetical-protein
MKRRFLFKNYGPDDQTIIQAIQHSVEISRKNNNSNIHIVFPRKSDFESTNLGKIIDQILGAGSAKKLTKGESIGSLDLLLPSRINSSNSSGTILAVYCTSHDMHLIDSNSSADDIIFVSWLPDEANHWENTWHNHGLIIMKGETSLNIPQIPEEIVQSLTNLTAIINLSTGLSHPSDKKHAEQIFKELSQKGYKADEEQIASWAIAHGWNASHLSDLKKLVRRYLS
>NC_021738.1|WP_006250672.1|436432_437098_-|CRISPR-associated-protein-Cas4
MDDLQNSTEILPLVQPKFGYDKRSISLSALQHYAFCPRQCALIHNEQVWAENYLTAQGQVLHERVDSGEPETRKGIRFERTVHVAAEKLGISGILDLVERDLKTGELKPVEYKRGKPKPEPMDEIQLCAQALCLEEMTGQTINEGALWYMQTRHRLPITFSTELRTKTLATISEVRSLLNSGTTPLPKYSKRCKACSLIDLCQPQLLDRDRSERYVEEIFK
>NC_021738.1|WP_006250671.1|437097_437961_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSIQNRYEFVFFFDVTNGNPNGDPDAGNMPRLDPETSKGLVTDVCLKRKIRNFIEMSYENEAGYEIYVKEKSVLNLQNKRAYEALGIESEAKKLPKEEAKAREITAWMCKNFFDIRTFGAVMTTEVNSGQVRGPVQLAFAQSIDPIIPLEVSITRMAVTNEKDLEKERTMGRKYIVPYALYRVHGFISAKLAEKTGFSDEDVQKLWQALQLMFEHDRSAARGEMAARKLIVFKHDSELGNQPAHKLFDSVKVERINGEKDTPAKDYDDYRISVQAEGLTGVTVEELL
>NC_021738.1|WP_006250670.1|437970_439755_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MILSALTRYYYRLAAQEDRLTGEAKVPSYGFSEEKIGWVLELDSKGNLVNVISNLTEDKKPKPKLMSVPRPEKRTSGIKPNFLWDKTAYVLGIESNPDKATAKDQPINFAEKTFEAFKQYHLDLLADSNDEGLMAIRNFLQQWQPTHFAESICPREILDANVVFKLVGTSGYIHQREAAQTLWTSLLINQSDNAEKGLCLISGKLSPIQRTHPPIKGVFGGQSSGGSIISFNKESFTSFGKEQGSNAPVSEQAAFAYTTALNYLLRTEKHRLTIGDASTVFWAEADNTTQAEAAEGFFAALMTPPDDEQENQKIFEELQKISKGRPLAEISPELSENTRFYVLGLAPNAARISVRFWLDTTFGQLAKNLSEHWQDLALEPCAWKTPPSIWRLLLQTASLGKSENISPVLAGEMARAVISGHLYPMSLLSQLVTRIRADGDINGLRVALMKAVLQRKFRKGFIKEGVPMSLNKESDNQAYLLGRLFAVLERIQTQALGELNAGIADRYYGSASAVPFSVFPRLLSGAKHHLSRLRKDKGGMAVNLDKDLGEIIASLPENFPRHLSIDEQGRFAIGYYHQKQSYFAKKETTESIEN
>NC_021738.1|WP_006248107.1|439751_440429_-|type-I-C-CRISPR-associated-protein-Cas5
MPNKIRLHIWGDYACFTRPEMKVERVSYDVITPSAARGILAAVHWKPAIRWVIDKIYVLQPIQFESVRRNELGSKISASKISGAMKRKTVADLYTVIEDDRQQRAATVLKNVGYVIEAHAVLTKMAGEAETVTKHIEMFKRRAKKGQCFQQPCMGVREFAANFALIDDDEPLPECFLAENERDRDLGWMLHDIDFEHGNQPRFFRAEMKNGVIDVPPFYAEEVKS
>NC_021738.1|WP_006250669.1|440666_442418_-|DUF87-domain-containing-protein
MANETLNFKDNARLGRVVTVDTSRVLISVEEHQQMTSIAVGNLIAIQGRTASEYLIGIIERVTRSISEKLLLEEISNEGEIPLGESQDDFIKAVLIGTYKAVDGSLSNTFKRGADCFPQIDRDCFHISGSNLQLFMNLLSANVKENERLTLGHFMADETAVAIANGDKFFQRHAAILGSTGSGKSWSVALILERAAALKAANLIVFDMHGEYSTLCEGKNAIAQQYRIAGPGDLDGSDERSLFIPYWLLNREEMLALILDRSDDNAPNQAARFTEHVRALKEQTLNKEERNDVLETFTVDSPIPYSIELLLARLDKDNSEMVPKEGGSGTKQGPWYSKLSRFMGRMKAKIDDRRCGFMFQPPVECNSYGWLENMLSKLFSASESEKGIKIIDFSEVPSDVLPIVTGVLARLLYNIQFWMDKDSRHPLTIICDEAHLYLPVRDSAEAAEKRALEAFERIAKEGRKYGVSLLVVSQRPSDVSRTILSQCNNFLVLRLTNDQDQSVVKRLLPESMVGITDILPLLDLGEALLLGDSILLPTRIKLAKPHIAPESATRQFWSDWANQEPKPNAVSNAVEALRRQVRS
>NC_021738.1|WP_020824140.1|442407_443463_-|SIR2-family-protein
MREPLLDEDELKKWLQTIFTDNLVIIVGSGLSCAEGLPGMGALADRLKERMPECLDDIDKVTWNTISDCLDSEGLEGALLKHQANETIEAAIIKITAEYVLSEEQKAINKCIAENQKLKFSYLLPHISASNPKIARVITTNYDRLIEFAAEYENWGIDSMMVGRYWGKHNPDLSRKLQIRDIRVKGKCPKLVYRDHIKIFKPHGSLDWFMAGDVPMTSCIGKVEEPLIITPGVGKYKKGYGQPFDAHREKANEAIDSASSILCIGYGFNDDHLQTHLTGKIKSGVKTLLLTRGLSENARNVVKEAPNCKALIFDGDKAGTRVVSKQEETFIPNVHWWDVEFFVKEILENGK
>NC_021738.1|WP_006250667.1|443593_445882_-|CRISPR-associated-helicase/endonuclease-Cas3
MEEHTIQSLYAHSGKLSDHSDWQTLLSHANNVGLLAAEFAAPFASQEIARCTGLLHDLGKYSERYQKRLHGGERVNHSTAGAKIAVERWGPLGKMMAFCIAGHHAGLANGSGEGKNRSTLTQRLQEQFGYGHKDLPVLDAIWQQELNLPEKLPLPPLKPSKNEPFFSYAFFIRMLYSCLVDADFLDTEAFYANLEKRPLERGNSPNLTALHQQFNQFIAQFRERITIQTPNTQEAQRKAEVNRLRSEILDYAVSQVKQETGLFSLTVPTGGGKTFTSMAFALEHAKQYGLCRIIYVIPFTSIIEQNAAEFRKAFGELGEEAVLEHHSTFDHDSLPDKSSRDKLKLASENWDAPVVVTTAVQFFESLFADRSSRCRKLHNIAGSVIILDEAQMLPLNLLRPIMAAIDELARNYQCSVVLCTATQPAIHQANGFYKGFENVREIAPNPTALFEKLKRTTVKHIGIQTDVELQSKLADNPQMLIIVNNRRHARALYDSAKQLEGAYHLTTLMCAKHRSQTLTEIRLRLKQNLPCRVIATSLIEAGVDVDFPLVMRAEAGLDSVAQAAGRCNREGKRLSVESNVWVFQPEEQWKAPPELGLLSGCMRSTVQVHADDLLNPKAINHYFQAVYEAKGKELDKPNILKACHDAGQSLNFPFQKIAEDFRMITSHLIPVIIPFDQEAENLIDRLRYADQVGGILRKLQPYTVQVPEKALAELYNAGRVETINETNFGKQFYCLIGMDLYDEVAGLSWENVDFLESEKLVL

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Crispr_ID: NC_021738_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021738_3

967434-967539

Orphan

Consensus_repeat	Method
ACTGTCAGATTAGGTTTGATCTTCTACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021738_3

>merge|NC_021738|3|967434-967539|CRISPRCasFinder
ACTGTCAGATTAGGTTTGATCTTCTACAAAGCATTTAAGCTCAAATTAATCTGACAGGCACTATAATTTTAAACGGGAACTGTCAGATTAGGTTTGATCTTCTACA

>NC_021738|3|3|967434-967539|CRISPRCasFinder
ACTGTCAGATTAGGTTTGATCTTCTACA	AAGCATTTAAGCTCAAATTAATCTGACAGGCACTATAATTTTAAACGGGA
ACTGTCAGATTAGGTTTGATCTTCTACA

Protein	Signature genes	Signature genes Name	Protein_function
NC_021738.1\|WP_006250878.1\|972382_973156_-\|Na(+)-translocating-NADH-quinone-reductase-subunit-C	unknown	unknown	gnl\|CDD\|235423
NC_021738.1\|WP_006250399.1\|964887_965199_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376187
NC_021738.1\|WP_006250393.1\|969918_971148_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-F	unknown	unknown	gnl\|CDD\|235481
NC_021738.1\|WP_006252088.1\|958453_959731_-\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234586
NC_021738.1\|WP_006250391.1\|971756_972383_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-D	unknown	unknown	gnl\|CDD\|236457
NC_021738.1\|WP_020824238.1\|963613_964777_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_021738.1\|WP_006250389.1\|973148_974384_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-B	unknown	unknown	gnl\|CDD\|235425
NC_021738.1\|WP_006250395.1\|969086_969380_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393
NC_021738.1\|WP_020824242.1\|968003_969038_-\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|224394
NC_021738.1\|WP_020824237.1\|960951_961950_-\|DUF4115-domain-containing-protein	unknown	unknown	gnl\|CDD\|236776
NC_021738.1\|WP_006250388.1\|974386_975745_-\|Na(+)-translocating-NADH-quinone-reductase-subunit-A	unknown	unknown	gnl\|CDD\|235426
NC_021738.1\|WP_032844760.1\|953255_955103_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_021738.1\|WP_006253177.1\|969372_969807_-\|nucleotidyltransferase-substrate-binding-protein	unknown	unknown	gnl\|CDD\|378048
NC_021738.1\|WP_006250404.1\|959736_960849_-\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|234737
NC_021738.1\|WP_006250406.1\|957823_958444_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|225523
NC_021738.1\|WP_006250407.1\|956657_957761_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|235541
NC_021738.1\|WP_006250397.1\|967745_967991_-\|(Na+)-NQR-maturation-NqrM	unknown	unknown	gnl\|CDD\|225538
NC_021738.1\|WP_006252085.1\|962117_963497_-\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179883
NC_021738.1\|WP_006252090.1\|955289_956639_+\|chromosomal-replication-initiator-protein-DnaA	unknown	unknown	gnl\|CDD\|273037
NC_021738.1\|WP_020824243.1\|971158_971755_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E	unknown	unknown	gnl\|CDD\|235074

Protein	Function_ID	Function_description	E-value
NC_021738.1\|WP_006250878.1\|972382_973156_-\|Na(+)-translocating-NADH-quinone-reductase-subunit-C	gnl\|CDD\|235423	PRK05346, PRK05346, Na(+)-translocating NADH-quinone reductase subunit C; Provisional.	1.35443e-143
NC_021738.1\|WP_006250399.1\|964887_965199_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	7.26223e-19
NC_021738.1\|WP_006250393.1\|969918_971148_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-F	gnl\|CDD\|235481	PRK05464, PRK05464, Na(+)-translocating NADH-quinone reductase subunit F; Provisional.	0
NC_021738.1\|WP_006252088.1\|958453_959731_-\|histidine--tRNA-ligase	gnl\|CDD\|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	0
NC_021738.1\|WP_006250391.1\|971756_972383_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-D	gnl\|CDD\|236457	PRK09292, PRK09292, Na(+)-translocating NADH-quinone reductase subunit D; Validated.	8.22874e-139
NC_021738.1\|WP_020824238.1\|963613_964777_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_021738.1\|WP_006250389.1\|973148_974384_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-B	gnl\|CDD\|235425	PRK05349, PRK05349, Na(+)-translocating NADH-quinone reductase subunit B; Provisional.	0
NC_021738.1\|WP_006250395.1\|969086_969380_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	1.17974e-11
NC_021738.1\|WP_020824242.1\|968003_969038_-\|FAD:protein-FMN-transferase	gnl\|CDD\|224394	COG1477, ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism].	1.20967e-126
NC_021738.1\|WP_020824237.1\|960951_961950_-\|DUF4115-domain-containing-protein	gnl\|CDD\|236776	PRK10856, PRK10856, cytoskeleton protein RodZ.	6.79277e-35
NC_021738.1\|WP_006250388.1\|974386_975745_-\|Na(+)-translocating-NADH-quinone-reductase-subunit-A	gnl\|CDD\|235426	PRK05352, PRK05352, Na(+)-translocating NADH-quinone reductase subunit A; Provisional.	0
NC_021738.1\|WP_032844760.1\|953255_955103_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.36996e-155
NC_021738.1\|WP_006253177.1\|969372_969807_-\|nucleotidyltransferase-substrate-binding-protein	gnl\|CDD\|378048	pfam08780, NTase_sub_bind, Nucleotidyltransferase substrate binding protein like. Nucleotidyltransferases (EC 2.7.7) comprise a large enzyme family with diverse roles in polynucleotide synthesis and modification. This domain is structurally related to kanamycin nucleotidyltransferase (KNTase) and forms a complex with HI0073, a sequence homolog of the nucleotide-binding domain of this nucleotidyltransferase superfamily.	6.0995e-37
NC_021738.1\|WP_006250404.1\|959736_960849_-\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl\|CDD\|234737	PRK00366, ispG, flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.	0
NC_021738.1\|WP_006250406.1\|957823_958444_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|225523	COG2976, COG2976, Uncharacterized protein conserved in bacteria [Function unknown].	4.99834e-50
NC_021738.1\|WP_006250407.1\|956657_957761_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|235541	PRK05643, PRK05643, DNA polymerase III subunit beta; Validated.	3.14157e-174
NC_021738.1\|WP_006250397.1\|967745_967991_-\|(Na+)-NQR-maturation-NqrM	gnl\|CDD\|225538	COG2991, COG2991, Uncharacterized protein conserved in bacteria [Function unknown].	7.16881e-29
NC_021738.1\|WP_006252085.1\|962117_963497_-\|argininosuccinate-lyase	gnl\|CDD\|179883	PRK04833, PRK04833, argininosuccinate lyase; Provisional.	0
NC_021738.1\|WP_006252090.1\|955289_956639_+\|chromosomal-replication-initiator-protein-DnaA	gnl\|CDD\|273037	TIGR00362, DnaA, chromosomal replication initiator protein DnaA. DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_021738.1\|WP_020824243.1\|971158_971755_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E	gnl\|CDD\|235074	PRK02830, PRK02830, Na(+)-translocating NADH-quinone reductase subunit E; Provisional.	4.0318e-125

>NC_021738.1|WP_006250399.1|964887_965199_-|nucleotidyltransferase-domain-containing-protein
MPNFGLSERATKTITDILAKYPEVEQAIIYGSRAKGNYREGSDVDLTFKGKDLTYDIVKRIWGDLDDSDSPYLFDLSIYHQLTNANFIEHIDRVGKVFYQREL
>NC_021738.1|WP_020824238.1|963613_964777_-|tRNA-2-thiouridine(34)-synthase-MnmA
MTTQLTSKTYDTHFPKLTPEQLAENSKKKVIIGMSGGVDSSVSAFILQQQGYQVEGLFMKNWEEDDDTDYCTAAADLADAQAVADKLGMKLHKINFAAEYWDNVFEYFLAEYKAGRTPNPDILCNKEIKFKAFLEYAAEDLGADYIATGHYVRRTSDDQDAKLLRGLDENKDQSYFLYALNKKQIGQSLFPVGEIEKPIVRVIAEDLGLATAKKKDSTGICFIGERKFKDFLARFLPAQPGEIRTVEGKLVGRHDGLMYHTLGQRKGLGIGGVKGLSEDPFYVVEKDLINNVLIVAQGHDNSALLSSGLIAKQLTWVDMQPLRENLRCTVKTRYRQADIACEIQVLDDETIRVMFDEPQIAVTPGQSAVFYLGEVCLGGGIIESQLK
>NC_021738.1|WP_006252085.1|962117_963497_-|argininosuccinate-lyase
MALWGGRFTQQADAKFKYFNNSLRFDYRLAIQDIEGSIGWAKAITSVGILTVAELEQLIAALKEVRAEVESNLTIILKDDAEDIHSWVESKLIEKVGDLGKKLHTGRSRNDQVAVDIKMWCKVQAVALQERIRALQERLVSVAEENQESVMPGYTHLQRAQPVTFAHWCMAYYEMLERDFSRLSDANKRMSTCPLGSGALAGTAYGIDRDLLARDLGFEEATRNSLDSVSDRDHILELLSTASISMMHLSRFAEDLIIFNSGESGFLEMSDRVTSGSSLMPQKKNPDACELIRGKSGRVFGALNGLLTTLKGLPLAYNKDMQEDKEGIFDALETWQACLEIAELVLVDIQVNTERTREAAQQGYANATELADYLVAKGVPFREAHHIVGEAVVYAISKKEPLEALSINEFQQFHHSIGDDVYPILSLESCLEKRCAKGGVNPQRVAEAIAVAKANLASK
>NC_021738.1|WP_020824237.1|960951_961950_-|DUF4115-domain-containing-protein
MTESVNSTQAGTALSLGQQLKAAREALNLSITDVAQKTNLKKSHIESLENDIFILQNVAPTFVRGYVRNYVKFLRLPESLISSVNYGEVTIPKEVTKVSSVKPSSNSQGKTLKYLTVLVLLAALGMTLLWWWQGYQKEQENREQFVSSAPVAEVANTATNNDASAQTSVPVQQPIQVSEQPAQVAETVVAAEPALTEKVEPTQAASSPVTQEDVKVVEEVKQADATTAQVEAVNVLQQSQSEQAPTEQPVAVTNDELRIEITGSQSWITVRGAKNKRLAEKLYNNGETLSFNENEQYRLTIGAPANVKVYYKGQEVPLKIDGRVARIRLPLQ
>NC_021738.1|WP_006250404.1|959736_960849_-|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MIHQSPIKRRVSKKIYVGNVPVGGDAPITVQSMTNTRTTDVEATVAQIKSLERVGADIVRVSVPTMDAAEAFKAIKQQVSVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRTVVDCARDKNIPIRIGVNAGSLERDLQEKYGEPTPQALLESALRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARAGSVKSAVGLGLLLAEGIGDTLRVSLAADPVEEVKVGFDILKSLRIRSRGINFIACPTCSRQEIDVIATVNELEQRLEDIITPMDVSIIGCVVNGPGEALVSDLGVTGSNKMSGFYLDGVRQKERFDNAKLIDQLEAKIRARVAQQHNRIDIEQIG
>NC_021738.1|WP_006252088.1|958453_959731_-|histidine--tRNA-ligase
MAKTIQAIRGMNDCSPSESPLWQWVEQKVRNVLASYGYSEVRMPIVESTPLFARAIGEVTDVVSKEMYTFWDNDEQLTLRPEGTAGCVRAAIERGWIYNNEQRLWYMGPMFRHERPQKGRYRQFHQAGVEVFGIANPEIDAELIILTARLWKELGIDQHVSLQLNSIGSLEARANYRSALVKFLENHTALMNEEEKERLVKNPLRILDTKNEALQNVLNDAPKLLDYLDDDSREHFTQLCALLDAMGIRYEVNPKLVRGLDYYNKTVFEWVTSALALGSQGTVCGGGRYDGLVEQLGGHATQGVGFAMGLERLVLLVQEVNKEIDLPKTVDVYIVFSGEGATLNAFQLAEQIRSELPHVGVMTHCSGGKFQKQFKRADKVEAQIALVIGESEVAEKQVVIKDLRSGAEQITIAQSELIAELSKRF
>NC_021738.1|WP_006250406.1|957823_958444_-|tetratricopeptide-repeat-protein
MSNEYLNKTEEQQFEDAKNWFKENGTPILVAIILACAATAGWNFWKNHQLETAQKTSASYQSVMESYLQNPSKNQPLVEKFIADNKDSSYAAFAQFEVAKQAVEKGNFSAAKTALQSVLTYSDSTLQSIARFRLAQIDFQLKSYDEALASLAQIQDKAWELRKQILTGDILAAKGDIPAAKSAYEQAKTTANPQEQTLIDVRLNNL
>NC_021738.1|WP_006250407.1|956657_957761_+|DNA-polymerase-III-subunit-beta
MQITITREQLLKPLQQVCGVLSSRPTLPVINNLLLEIEGNRLSLTGTDLEVELTTQAQLLQAVDFAGKFTIPAKKFLDISKSLPDDSVISVQFEEDKAIIKAGRSKFSLATLPASDYPNLMDWKPEVDFSIDQSTLARLIDATQFSMANQDARYFLNGMKFETEGNLLRTVATDGHRLAVCTMVLNQELLTHSVIVPRKAVLELSRLVASNDETVRLEIGSSNIRITMNGIVFTSKLIDGRFPDYRRVLPRNADRILEAETETLKRALMRAAILSNEKFRGVRLTLSNNLLKITANNPEQEEAEEIIDVAYDSPEMEVGFNVSYVLDVLNTLKCQRVRFSLVDSSSSCLIEDCDNSSAEYVIMPMRL
>NC_021738.1|WP_006252090.1|955289_956639_+|chromosomal-replication-initiator-protein-DnaA
MEQIVSSLWSDCLNHLQTKVSPTDYSTWLRPLQASSENGELTLYAQNQFVENWVKDKFLSEITELARFLAKNDNLVVTLKVGIKPTEQPKVSPNLKNESSEFSNTGFKTGLNPNQTFDNFVQGRSNQLAKLVAQQVVDNLGESHCNPLSFYAGTGLGKTHLLHAIGNELVKRTPGTRVLYIHLERFYRDIIKAINSSNNDAEKIKKFYRSLDVLMIDDIQFLANKPKVQEEFLHLLNSLFEQRKQIILTSDVLPKNIDKIDTAIKSRLSGGISATIEPPELETRVAILRQKALERGADLQEDAAYLMGQKLRTNVRELEGALNRVIAWQKLTLRPITVDAVRETLQDLFASFDYLITIENIQRIVAEYYGIKVADIKSKSRARSIARPRQMAMALAKELTNHSLPEIGREFGGRDHTTVMHACKTINELRDTESGIQEDYIHLTRKLSS
>NC_021738.1|WP_032844760.1|953255_955103_+|ABC-transporter-ATP-binding-protein
MFEKLFQWFEARVETYPNETPRTPKSGLIPFIYDATKGMRFYILLLTVLVAAVGIIEAVLFRFMGDLVDWVNKYSPTELWAEKGWTIIGMFFIALLAVVFVYLASSIRFQSLQGVFPMRLRWNFHRLMLGQSLGFYQDEFAGRVSAKVMQTALSVRDVIMTCADMLVYVLVYFTTSSVILLQLDGWLFVPFILWVISLAATIIYFVPKLAQAAQEQSDARSLMTGRITDAYANIATVKLFSHGNRESAYAKESMEEFMVTVHKQMRLVTVIETVTNLTSMALIISTAGIGLWLWGSSVVTAGAIATSTALALRIKGLSQWIMWEFARLFENLGTVQDGMITLSKPHNVVDKIDAKPLNVTKGEIKFENVDFAYDPKKPLLKDFDLTIKPGEKVGLVGRSGAGKSTLTNLLLRFYDIQDGSITIDGQNIRDITQESLRSQIGLVTQDTSLLHRSVRENLMYGRPNATEEEMIKAVEQAAASEFIPNLQDAKGRTGFDAHVGERGVKLSGGQRQRIAIARVMLKDAPILLLDEATSALDSEVEVAIQENLTQLMEGKTVVAIAHRLSTIMAMDRLIVLDKGEIVEQGTHEELLAQNGVYARLWAHQSGGFLPENTDI
>NC_021738.1|WP_006250397.1|967745_967991_-|(Na+)-NQR-maturation-NqrM
METVLLTFGFFVAVIFAMSIGFIVKGKTIKGSCGGITALGMKKMCDCEEPCDNLKSKIADGTADPEEVARFNKEPQFYEVK
>NC_021738.1|WP_020824242.1|968003_969038_-|FAD:protein-FMN-transferase
MKKFFLLLIAFFTLSACEKAPEQITLSGKTMGTTYTVKYIDNGEVENLISPEKMKNELDGLLIEVNNQMSTYQQDSEISRFNQAKQANQAVEISQDFAKVVQEAIRLNKVTEGALDVTVGPLVNLWGFGPDKRLNKVPSDEQIAERSAYVGIDKILLEMSSKPKLTKSAANLYLDLSSIAKGFGVDKLAEHLETIGVSNYLVEIGGELRGKGKNLQGLDWRIAIEQPVMTQGQAAQITVPLHNLAMATSGNYRNYFEDEKGNRLSHIIDPKQLRPVNHNLASITVFAPTTMTADGLSTGLFVLGAEKALAVAEREKLAIFLIVKNGDKFETQMSSEFSKLIQSQ
>NC_021738.1|WP_006250395.1|969086_969380_-|nucleotidyltransferase-domain-containing-protein
MIDLTESQRQQVLDIFKKYLPDTPVWVFGSRIKGTAKAYSDLDLALITKQPLTIRQQTELELAFTDSDLPFTVDLIDWASCNESFKQIILQRYEVLI
>NC_021738.1|WP_006253177.1|969372_969807_-|nucleotidyltransferase-substrate-binding-protein
MEQLDITALENAFNSLEKTIVSLENQAWFNRQEAIIQDTLIAGAIQKFEFVYELSIKMLKRQLKNIESNDTDIDSTEFRDILRMAAQYGLIESPEVWLDYRKMRNITSHTYDQNKAQQVYNGISNFLESTYFLVKQLQKRNSYD
>NC_021738.1|WP_006250393.1|969918_971148_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-F
MDSNFIFGIIAFTALVLVLAVIILFAKSKLVDSGDITISINNDPEKGITLPAGGKLLGALASKGIFVSSACGGGGSCGQCKVQVKSGGGEILPTELSHISKKEAKEGWRLACQVNVKSSMDVELPEEIFGVKKWECTVISNDNKATFIKELKLQIPEGEEVPFRAGGYIQIEAEPHTVHYKDFDIPKEYHEDWDKFDLWRYTSKVDEHIIRAYSMASYPEEKGIIMLNVRIATPPPRNPDVPPGQMSSYIWSLKPGDKVTISGPFGEFFAKDTDAEMVFIGGGAGMAPMRSHIFDQLKRLKSKRKMSFWYGARSEREMFYVEDFDGLQAENDNFKWYVALSDPLPGDREDYFRGFIHNVLYENYLKNHEAPEDCEYYMCGPPVMNAAVIGMLKSLGVEDENILLDDFGG
>NC_021738.1|WP_020824243.1|971158_971755_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E
MEHLLSIFVKSVFIENMALSFFLGMCTFLAVSKKVSTAFGLGIAVIVVLGIAVPANQLVYTHVLKEGALVEGVDLSFLNFITFIGVIAALVQILEMILDKFFPALYSALGIFLPLITVNCAIFGGVSFMVQREYNFVESVVYGVGAGTGWMLAIVALAGLTEKMKYSDVPAGLRGLGITFITVGLMALGFMSFSGIQL
>NC_021738.1|WP_006250391.1|971756_972383_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-D
MADNNNLKKLLLSPIVDNNPIALQILGICSALAVTTQLQTAVVMAIAVSLVTAFSSMFISMIRNYIPNSIRIIVQMAIIASLVILVDQILRAYAYDLSKQLSVFVGLIITNCIVMGRAEAFAMKSGPVESFVDGIGNGLGYGAMLIIVAFLRELIGSGKIFGITILETVQNGGWYQANGLFLLAPSAFFIIGFVIWAIRTWKPEQVEK
>NC_021738.1|WP_006250878.1|972382_973156_-|Na(+)-translocating-NADH-quinone-reductase-subunit-C
MAKFNKDSVGGTLTVVVLLSLICSLIVAGAAVMLKPTQDIQKQLDKQKNILQAAGLLQKDTNVQETYTKFIEPKIVDLATGDYVEGVTGFDARAAAKDPAQNVVIAPEDDKANIKTRAKYAEVYLVKDESGKTTQVVLPMHGNGLWSIMYGFVAVQPDANTVNGITYYEQGETAGLGGEIVNPNWQKNFVGKKLYNEQNQVALRVGKGASADKDHGVDGLSGATLTSNGVDGSFKYWFGQNGFGPYLAKFKAAAGAN
>NC_021738.1|WP_006250389.1|973148_974384_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-B
MGLKNLFEKMEPAFHKGGKYEKWYTLFEAAYTIFYTPGTVTRKDAHVRDAIDSKRMMLIVWLALFPAMFYGMYNVGAQGILAALKMGTLTDLVANNWHYSLADSLGSVADAGWGTKMLLGATYFLPIYLTVFAVGGFWEVVFAMVRKHEINEGFFVTSILLALIVPPTLPLWQAALATTFGVVVAKEVFGGVGKNFMNPALAGRAFLFFAYPGQISGDAVWVAADGFSGATALSQWAVGGQGALQHVATGETITWMDAFLGNIPGSIGETSTLMLIIGAAIIVFARIASWRIIAGVMIGMAATATLFNVIGSDTNPLFSMPWHWHLVLGGFAIGMFFMATDPVSAAFTNKGKWAYGILIGFMCVLIRVVNPAYPEGMMLAILFANLFAPIFDYLVVQGNIKRRLARVANNG
>NC_021738.1|WP_006250388.1|974386_975745_-|Na(+)-translocating-NADH-quinone-reductase-subunit-A
MITIKKGLDLPIAGKPEQVIHNGNTVTEVAMLGEEYVGMRPSMKVREGDVVKKGQVLFEDKKNPGVVFTAPASGTVTAINRGEKRVLQSVVIKVEGDEQITFARYEASQLASLTSEQVKQNLVESGLWTAFRTRPFSKVPALDAEPSSIFVNAMDTNPLAANPEVIIAEHQQAFFDGLTVLSRLFESKKVIHLCGSADSNILNAAQSRQINNVETNRFKGPHPAGLSGTHIHFIDPVGATKQVWYLNYQDVIAIGKLFTTGELFTDRVVALAGPQVKNPRLVRTRLGANLSQLTANELNAGENRVISGSVLSGAIATGVHDYLGRYALQVSALLEGREKAFFGMIAPYSDKYSITRTTLGHFAKKLFNFTTAVHGSERAMVPTGAYERVMPLDIIPTLLLRDLAAGDTDSAQALGCLELDEEDLALCTFVCSGKNNWGPLLRQALDKIEKDG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_021738_3	3.1\|967462\|50\|NC_021738\|CRISPRCasFinder	967462-967511	50	NC_021738.1	2168802-2168851	0	1.0
NC_021738_3	3.1\|967462\|50\|NC_021738\|CRISPRCasFinder	967462-967511	50	NC_021738.1	635174-635223	0	1.0
NC_021738_3	3.1\|967462\|50\|NC_021738\|CRISPRCasFinder	967462-967511	50	NC_021738.1	211278-211327	1	0.98

1. spacer 3.1|967462|50|NC_021738|CRISPRCasFinder matches to position: 2168802-2168851, mismatch: 0, identity: 1.0

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	Protospacer
**************************************************

2. spacer 3.1|967462|50|NC_021738|CRISPRCasFinder matches to position: 635174-635223, mismatch: 0, identity: 1.0

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	Protospacer
**************************************************

3. spacer 3.1|967462|50|NC_021738|CRISPRCasFinder matches to position: 211278-211327, mismatch: 1, identity: 0.98

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagcatttaagctcaaattaatctgacagacactataattttaaacggga	Protospacer
*****************************.********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021738_2	2.1\|433705\|35\|NC_021738\|CRISPRCasFinder,CRT	433705-433739	35	NC_028853	Mannheimia phage vB_MhS_535AP2, complete genome	31900-31934	0	1.0
NC_021738_2	2.1\|433705\|35\|NC_021738\|CRISPRCasFinder,CRT	433705-433739	35	KP137439	Mannheimia phage vB_MhS_3927AP1, complete genome	33856-33890	0	1.0
NC_021738_2	2.1\|433705\|35\|NC_021738\|CRISPRCasFinder,CRT	433705-433739	35	NC_028956	Mannheimia phage vB_MhS_1152AP2, complete genome	33963-33997	0	1.0
NC_021738_3	3.1\|967462\|50\|NC_021738\|CRISPRCasFinder	967462-967511	50	NC_007800	Bibersteinia trehalosi plasmid pCCK13698, complete sequence	913-962	1	0.98
NC_021738_3	3.1\|967462\|50\|NC_021738\|CRISPRCasFinder	967462-967511	50	NZ_CP018033	Glaesserella parasuis D74 plasmid pD74, complete sequence	6036-6085	2	0.96
NC_021738_3	3.1\|967462\|50\|NC_021738\|CRISPRCasFinder	967462-967511	50	NZ_CP054196	Glaesserella parasuis strain YHP170504 plasmid unnamed2, complete sequence	1676-1725	2	0.96
NC_021738_3	3.1\|967462\|50\|NC_021738\|CRISPRCasFinder	967462-967511	50	NC_006829	Haemophilus parasuis plasmid pHS-Rec, complete sequence	8881-8930	2	0.96
NC_021738_1	1.1\|8760\|29\|NC_021738\|CRISPRCasFinder	8760-8788	29	MH791397	UNVERIFIED: Enterococcus phage EfsSzw-1, complete genome	22354-22382	5	0.828
NC_021738_2	2.5\|433772\|32\|NC_021738\|PILER-CR	433772-433803	32	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	627317-627348	7	0.781
NC_021738_2	2.1\|433705\|35\|NC_021738\|CRISPRCasFinder,CRT	433705-433739	35	NZ_CP020003	Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed1, complete sequence	42539-42573	10	0.714
NC_021738_2	2.2\|433772\|35\|NC_021738\|CRISPRCasFinder,CRT	433772-433806	35	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	627317-627351	10	0.714

1. spacer 2.1|433705|35|NC_021738|CRISPRCasFinder,CRT matches to NC_028853 (Mannheimia phage vB_MhS_535AP2, complete genome) position: , mismatch: 0, identity: 1.0

aattgcctgtacatcaacataaccacaaacacgga	CRISPR spacer
aattgcctgtacatcaacataaccacaaacacgga	Protospacer
***********************************

2. spacer 2.1|433705|35|NC_021738|CRISPRCasFinder,CRT matches to KP137439 (Mannheimia phage vB_MhS_3927AP1, complete genome) position: , mismatch: 0, identity: 1.0

aattgcctgtacatcaacataaccacaaacacgga	CRISPR spacer
aattgcctgtacatcaacataaccacaaacacgga	Protospacer
***********************************

3. spacer 2.1|433705|35|NC_021738|CRISPRCasFinder,CRT matches to NC_028956 (Mannheimia phage vB_MhS_1152AP2, complete genome) position: , mismatch: 0, identity: 1.0

aattgcctgtacatcaacataaccacaaacacgga	CRISPR spacer
aattgcctgtacatcaacataaccacaaacacgga	Protospacer
***********************************

4. spacer 3.1|967462|50|NC_021738|CRISPRCasFinder matches to NC_007800 (Bibersteinia trehalosi plasmid pCCK13698, complete sequence) position: , mismatch: 1, identity: 0.98

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagcatttaagctcaaattaatctgacagacactataattttaaacggga	Protospacer
*****************************.********************

5. spacer 3.1|967462|50|NC_021738|CRISPRCasFinder matches to NZ_CP018033 (Glaesserella parasuis D74 plasmid pD74, complete sequence) position: , mismatch: 2, identity: 0.96

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagtatttaagctcaaattaatctgacagacactataattttaaacggga	Protospacer
***.*************************.********************

6. spacer 3.1|967462|50|NC_021738|CRISPRCasFinder matches to NZ_CP054196 (Glaesserella parasuis strain YHP170504 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.96

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagtatttaagctcaaattaatctgacagacactataattttaaacggga	Protospacer
***.*************************.********************

7. spacer 3.1|967462|50|NC_021738|CRISPRCasFinder matches to NC_006829 (Haemophilus parasuis plasmid pHS-Rec, complete sequence) position: , mismatch: 2, identity: 0.96

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagtatttaagctcaaattaatctgacagacactataattttaaacggga	Protospacer
***.*************************.********************

8. spacer 1.1|8760|29|NC_021738|CRISPRCasFinder matches to MH791397 (UNVERIFIED: Enterococcus phage EfsSzw-1, complete genome) position: , mismatch: 5, identity: 0.828

tctttataccctagattagtatcaggtct	CRISPR spacer
gccttataccctagattattatgaggttt	Protospacer
 *.*************** *** ****.*

9. spacer 2.5|433772|32|NC_021738|PILER-CR matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 7, identity: 0.781

tcgaaaatcttccacgcatttacgccgatgtc	CRISPR spacer
aagaaaatcttccacccatttacgctgatcct	Protospacer
  ************* *********.*** ..

10. spacer 2.1|433705|35|NC_021738|CRISPRCasFinder,CRT matches to NZ_CP020003 (Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

aattgcctgtacatcaacataaccacaaacacgga	CRISPR spacer
tctcttttgttcatcaacataaccataaacacgat	Protospacer
  *. ..*** **************.*******.

11. spacer 2.2|433772|35|NC_021738|CRISPRCasFinder,CRT matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 10, identity: 0.714

tcgaaaatcttccacgcatttacgccgatgtcagt	CRISPR spacer
aagaaaatcttccacccatttacgctgatcctttg	Protospacer
  ************* *********.*** ..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

359319 : 411867

Mannheimia_phage(46.15%)

integrase,plate,terminase,head,holin

attL 361894:361913|attR 412019:412038

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_006252023.1\|359319_359784_-	hypothetical protein	F6MIM0	Haemophilus_phage	2.6e-54	63.0
WP_020824100.1\|359776_360400_-	DUF4376 domain-containing protein	A0A0M3LRX2	Mannheimia_phage	1.1e-111	97.1
WP_020824101.1\|360400_363340_-	hypothetical protein	A0A0M3LS19	Mannheimia_phage	0.0e+00	93.5
361894:361913	attL	NA	NA	NA	NA
WP_006252064.1\|363412_364033_-	DUF2612 domain-containing protein	A0A220NQG4	Acinetobacter_phage	3.7e-27	37.2
WP_006252668.1\|364029_365226_-\|plate	baseplate J/gp47 family protein	K4I3B4	Acinetobacter_phage	3.0e-62	36.6
WP_006252062.1\|365222_365573_-	hypothetical protein	A0A2R3UAP1	Myoviridae_environmental_samples	1.7e-13	39.5
WP_006252669.1\|365576_366239_-	hypothetical protein	A0A2R3UAK1	Myoviridae_environmental_samples	2.1e-36	42.0
WP_006252670.1\|366228_367116_-	hypothetical protein	K4I0K5	Acinetobacter_phage	3.6e-44	34.2
WP_132303704.1\|367115_367412_-	hypothetical protein	NA	NA	NA	NA
WP_020824103.1\|367414_368122_-	hypothetical protein	A0A1X9SFH6	Acinetobacter_phage	1.8e-33	45.5
WP_020824105.1\|368356_369253_-	ORF6C domain-containing protein	Q0H8C7	Salmonella_phage	1.4e-35	40.4
WP_006252056.1\|369537_369717_-	hypothetical protein	D0UIH9	Aggregatibacter_phage	4.0e-19	84.7
WP_006252055.1\|369868_370540_-	SHOCT domain-containing protein	NA	NA	NA	NA
WP_006252054.1\|370562_371225_-	hypothetical protein	NA	NA	NA	NA
WP_020824107.1\|371224_373894_-	peptidoglycan-binding protein LysM	A0A1V0DZ47	Acinetobacter_phage	3.3e-64	31.9
WP_006252675.1\|373893_374040_-	hypothetical protein	NA	NA	NA	NA
WP_020824108.1\|374066_374471_-	hypothetical protein	NA	NA	NA	NA
WP_006252051.1\|374538_375060_-	phage antirepressor N-terminal domain-containing protein	A0A0M3LR56	Mannheimia_phage	4.4e-34	53.5
WP_006252050.1\|375194_375638_-	hypothetical protein	Q8HAQ5	Burkholderia_phage	4.5e-11	35.1
WP_006252049.1\|375695_377174_-	DUF3383 domain-containing protein	K4PB47	Acinetobacter_phage	3.9e-99	41.3
WP_006252048.1\|377189_377696_-	hypothetical protein	NA	NA	NA	NA
WP_006252047.1\|377680_378061_-	hypothetical protein	NA	NA	NA	NA
WP_020824109.1\|378068_378773_-	hypothetical protein	NA	NA	NA	NA
WP_006252044.1\|379376_379808_-	DUF4054 domain-containing protein	A0A0S1WH65	Pseudomonas_phage	2.8e-26	45.9
WP_006252043.1\|379810_380185_-	hypothetical protein	Q6IWU7	Burkholderia_phage	3.1e-13	36.0
WP_006252679.1\|380254_381385_-	DUF2184 domain-containing protein	I6ZXX2	Escherichia_phage	9.9e-79	46.0
WP_006252041.1\|381396_381906_-	hypothetical protein	NA	NA	NA	NA
WP_020824111.1\|381917_383174_-	DUF2213 domain-containing protein	Q6IWU4	Burkholderia_phage	2.4e-41	40.0
WP_006252680.1\|384412_385243_-\|head	phage head protein	H9C0V1	Aeromonas_phage	8.4e-19	28.7
WP_020824114.1\|385217_386729_-	DUF1073 domain-containing protein	I7B6L5	Escherichia_phage	4.3e-114	48.7
WP_020824115.1\|386796_388176_-\|terminase	phage terminase large subunit	A0A0D4DCE6	Acinetobacter_phage	4.5e-150	60.9
WP_020824116.1\|388178_388676_-	hypothetical protein	C7U0W1	Enterobacteria_phage	8.8e-48	70.4
WP_020824118.1\|389065_389299_-	hypothetical protein	A0A0M3LNX0	Mannheimia_phage	3.2e-32	89.2
WP_020824119.1\|389264_389594_-	DUF2570 domain-containing protein	A0A0M3LPB1	Mannheimia_phage	3.2e-22	93.6
WP_020824120.1\|389594_390191_-	glycoside hydrolase family 19 protein	A0A0M3LPP0	Mannheimia_phage	8.2e-93	84.3
WP_165876904.1\|390205_390565_-\|holin	phage holin, lambda family	A0A0M3ULK9	Salmonella_phage	2.5e-12	36.4
WP_006251969.1\|390700_391174_-	hypothetical protein	A0A0M3LPW4	Mannheimia_phage	1.7e-80	96.2
WP_020824122.1\|391163_391733_-	recombination protein NinG	A0A0M3LTG3	Mannheimia_phage	5.1e-84	84.7
WP_020824123.1\|391805_392267_-	DUF1367 family protein	A0A0M3LPN2	Mannheimia_phage	1.4e-31	45.8
WP_020824124.1\|392287_392860_-	phage N-6-adenine-methyltransferase	A0A0M3LNW2	Mannheimia_phage	2.8e-106	97.4
WP_020824125.1\|392870_393917_-	conserved phage C-terminal domain-containing protein	M4SQA9	Psychrobacter_phage	1.1e-23	52.6
WP_006252350.1\|393913_394753_-	Rha family transcriptional regulator	A0A2H4J5H6	uncultured_Caudovirales_phage	2.2e-27	37.4
WP_006252074.1\|394815_395259_-	hypothetical protein	NA	NA	NA	NA
WP_006252073.1\|395307_395502_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_006252072.1\|395598_396258_+	aspartate carbamoyltransferase	NA	NA	NA	NA
WP_006252071.1\|396257_397097_+	helix-turn-helix domain-containing protein	A0A1W6JNY2	Morganella_phage	5.2e-16	28.9
WP_006252070.1\|397113_397941_+	hypothetical protein	M9NYX6	Enterobacteria_phage	1.8e-58	44.8
WP_020824126.1\|397956_398292_-	hypothetical protein	NA	NA	NA	NA
WP_032849124.1\|398339_398798_-	hypothetical protein	NA	NA	NA	NA
WP_006252067.1\|398954_399251_+	hypothetical protein	NA	NA	NA	NA
WP_006248786.1\|399716_399968_+	hypothetical protein	A0A0M3LNV4	Mannheimia_phage	1.7e-31	85.2
WP_006248787.1\|399970_400246_-	hypothetical protein	A0A1J0MFQ1	Staphylococcus_phage	1.2e-06	30.4
WP_006252947.1\|400923_401439_+	DUF4760 domain-containing protein	NA	NA	NA	NA
WP_020824127.1\|401705_402416_+	Bro-N domain-containing protein	A0A0R6PDL2	Moraxella_phage	8.5e-28	53.5
WP_020824128.1\|402522_403029_+	hypothetical protein	A0A0M3LTE5	Mannheimia_phage	1.1e-85	91.1
WP_006252960.1\|403032_403392_+	hypothetical protein	A0A0M3LSX3	Mannheimia_phage	2.7e-59	95.8
WP_020824129.1\|403388_403868_+	hypothetical protein	A0A0M3LSK4	Mannheimia_phage	3.1e-74	95.0
WP_020824130.1\|404001_404214_+	hypothetical protein	A0A0M3LQ55	Mannheimia_phage	8.9e-34	100.0
WP_020824131.1\|404226_405150_+	recombinase RecT	A0A0M3LNU3	Mannheimia_phage	2.9e-169	100.0
WP_032848956.1\|405142_405805_+	translocation protein TolB precursor	A0A0M3LP90	Mannheimia_phage	4.5e-124	100.0
WP_006252710.1\|405845_406112_+	hypothetical protein	A0A0M3LPL3	Mannheimia_phage	2.6e-06	100.0
WP_006252708.1\|406139_406592_+	hypothetical protein	A0A0M3LNU4	Mannheimia_phage	1.1e-84	99.3
WP_006252707.1\|406690_406909_+	DUF551 domain-containing protein	A0A0M3LS47	Mannheimia_phage	1.7e-32	98.4
WP_020824132.1\|408792_409635_+	ORF6C domain-containing protein	Q7Y5X0	Haemophilus_phage	1.5e-36	62.8
WP_006247825.1\|409886_410063_+	hypothetical protein	A0A0M3LR16	Mannheimia_phage	2.8e-25	100.0
WP_020824134.1\|410150_410534_+	hypothetical protein	A0A0M3LPT1	Mannheimia_phage	9.1e-69	99.2
WP_006247823.1\|410583_410805_+	DUF4224 domain-containing protein	A0A0M3LQA2	Mannheimia_phage	1.3e-35	100.0
WP_020824135.1\|410826_411867_+\|integrase	tyrosine-type recombinase/integrase	A0A0M3LQJ3	Mannheimia_phage	2.4e-196	96.2
412019:412038	attR	NA	NA	NA	NA

DBSCAN-SWA_2

854337 : 918617

Mannheimia_phage(57.45%)

integrase,tail,protease,tRNA,terminase,portal,transposase,holin

attL 856210:856227|attR 916604:916621

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020824044.1\|854337_855378_+\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	4.2e-201	99.7
WP_006247810.1\|855450_855750_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_006247811.1\|855721_856111_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
856210:856227	attL	NA	NA	NA	NA
WP_006247812.1\|856254_856548_+	hypothetical protein	A0A0M3LSV5	Mannheimia_phage	5.7e-47	99.0
WP_006247809.1\|857972_858131_-	hypothetical protein	NA	NA	NA	NA
WP_020824195.1\|858140_865274_-	DUF1983 domain-containing protein	A0A0M3LQ28	Mannheimia_phage	0.0e+00	97.4
WP_020824196.1\|865276_865867_-\|tail	tail assembly protein	A0A0M3LQ39	Mannheimia_phage	1.8e-103	100.0
WP_020824197.1\|866135_866867_-	C40 family peptidase	A0A0M3LP75	Mannheimia_phage	1.8e-145	98.8
WP_020824198.1\|866870_867587_-\|tail	phage minor tail protein L	A0A0M3LSQ5	Mannheimia_phage	3.7e-132	96.6
WP_020824199.1\|867586_867916_-\|tail	phage tail protein	A0A2R9YJM0	Escherichia_phage	5.3e-17	38.9
WP_020824200.1\|867915_871467_-\|tail	phage tail tape measure protein	A0A125RN77	Pseudomonas_phage	1.2e-34	35.4
WP_020824201.1\|871520_871748_-	hypothetical protein	NA	NA	NA	NA
WP_020824202.1\|871810_872041_-	DUF4035 domain-containing protein	NA	NA	NA	NA
WP_020824203.1\|872085_872487_-	hypothetical protein	NA	NA	NA	NA
WP_020824204.1\|872569_873211_-	hypothetical protein	NA	NA	NA	NA
WP_020824205.1\|873238_873631_-\|tail	phage tail protein	NA	NA	NA	NA
WP_020824206.1\|873627_874152_-\|tail	phage tail protein	M9NZH5	Enterobacteria_phage	4.2e-16	38.1
WP_020824207.1\|874155_874458_-\|tail	phage tail protein	NA	NA	NA	NA
WP_020824208.1\|874450_874774_-	DUF2190 family protein	K7PLV6	Enterobacteria_phage	2.7e-13	37.4
WP_158497199.1\|874786_874948_-	hypothetical protein	NA	NA	NA	NA
WP_020824209.1\|875026_876988_-\|protease	Clp protease ClpP	A0A1W6JT88	Pseudomonas_phage	1.7e-198	55.2
WP_020824210.1\|877391_878588_-	hypothetical protein	NA	NA	NA	NA
WP_020824211.1\|878591_880103_-\|portal	phage portal protein	S5MW34	Escherichia_phage	3.7e-158	56.1
WP_015484701.1\|880102_880327_-	hypothetical protein	NA	NA	NA	NA
WP_020824212.1\|880323_882435_-\|terminase	phage terminase large subunit family protein	A5LH27	Enterobacteria_phage	3.2e-272	67.6
WP_020824213.1\|882434_882914_-	DUF1441 family protein	K7PJY2	Enterobacterial_phage	1.2e-41	58.0
WP_020824118.1\|883183_883417_-	hypothetical protein	A0A0M3LNX0	Mannheimia_phage	3.2e-32	89.2
WP_020824214.1\|883382_883712_-	DUF2570 domain-containing protein	A0A0M3LPB1	Mannheimia_phage	2.8e-26	100.0
WP_020824215.1\|883712_884306_-	glycoside hydrolase family 19 protein	A0A0M3LPP0	Mannheimia_phage	8.2e-109	97.0
WP_020824216.1\|884295_884649_-\|holin	phage holin, lambda family	A0A0M3LNX1	Mannheimia_phage	1.1e-60	99.1
WP_006250096.1\|884791_884962_-	hypothetical protein	A0A0M3LPX3	Mannheimia_phage	4.6e-25	100.0
WP_006251707.1\|884987_885173_-	hypothetical protein	A0A0M3LQD0	Mannheimia_phage	5.2e-30	100.0
WP_006251708.1\|885681_885876_+	hypothetical protein	A0A0M3LS93	Mannheimia_phage	2.0e-11	61.9
WP_006252752.1\|885843_886284_-	hypothetical protein	A0A0M3LR87	Mannheimia_phage	6.4e-42	63.0
WP_020824218.1\|886273_886633_-	RusA family crossover junction endodeoxyribonuclease	A0A0M3LPZ2	Mannheimia_phage	1.3e-13	33.9
WP_020824219.1\|886625_887654_-	DUF968 domain-containing protein	S5MW46	Escherichia_phage	5.3e-47	36.7
WP_020824220.1\|887780_888374_-	N-6-adenine methyltransferase	A0A0M3LNW2	Mannheimia_phage	1.7e-93	82.1
WP_020824125.1\|888384_889431_-	conserved phage C-terminal domain-containing protein	M4SQA9	Psychrobacter_phage	1.1e-23	52.6
WP_006252350.1\|889427_890267_-	Rha family transcriptional regulator	A0A2H4J5H6	uncultured_Caudovirales_phage	2.2e-27	37.4
WP_006252483.1\|890442_890703_-	hypothetical protein	A0A0M3LTF5	Mannheimia_phage	6.2e-37	97.7
WP_006248825.1\|890723_890924_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_006252485.1\|891054_891738_+	hypothetical protein	K7PKK1	Enterobacteria_phage	1.4e-19	31.1
WP_006248823.1\|891812_892193_+	hypothetical protein	A0A0M3LQX0	Mannheimia_phage	1.6e-73	100.0
WP_006252741.1\|892197_892683_+	hypothetical protein	A0A0M3LP99	Mannheimia_phage	5.8e-44	97.9
WP_006250075.1\|892813_892996_+	type II toxin-antitoxin system HicA family toxin	A0A0M3LQ86	Mannheimia_phage	3.6e-07	51.7
WP_006250984.1\|893034_893454_+	type II toxin-antitoxin system HicB family antitoxin	Q7Y3V7	Yersinia_phage	8.5e-28	48.9
WP_006250985.1\|893520_893826_-	HigA family addiction module antidote protein	A0A0M3LPV0	Mannheimia_phage	8.6e-54	99.0
WP_006250986.1\|893834_894110_-	type II toxin-antitoxin system RelE/ParE family toxin	A0A0M3LQB1	Mannheimia_phage	1.7e-48	100.0
WP_006250987.1\|894399_894630_+	hypothetical protein	A0A0M3LQL0	Mannheimia_phage	2.5e-37	98.7
WP_006250988.1\|895108_895432_-	hypothetical protein	NA	NA	NA	NA
WP_020824222.1\|895624_895810_+	hypothetical protein	NA	NA	NA	NA
WP_020824223.1\|895793_895958_+	hypothetical protein	NA	NA	NA	NA
WP_006253113.1\|895963_896422_+	single-stranded DNA-binding protein	F8TUL2	EBPR_podovirus	9.3e-36	48.7
WP_006250991.1\|896457_896817_+	hypothetical protein	A0A192Y6G0	Salmonella_phage	2.8e-19	51.5
WP_020824224.1\|896888_897692_+	YfdQ family protein	I3PUY7	Vibrio_phage	1.2e-49	40.1
WP_020824225.1\|897785_898220_+	hypothetical protein	S4T7U9	Vibrio_phage	1.6e-05	39.1
WP_020824226.1\|898229_898718_+	DUF551 domain-containing protein	A0A0M3LS47	Mannheimia_phage	6.0e-65	74.1
WP_020824227.1\|898738_898948_+	hypothetical protein	NA	NA	NA	NA
WP_006248807.1\|899094_899220_+	Com family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_020824228.1\|899266_900109_+	hypothetical protein	F6MIM2	Haemophilus_phage	6.8e-109	66.5
WP_020824134.1\|900171_900555_+	hypothetical protein	A0A0M3LPT1	Mannheimia_phage	9.1e-69	99.2
WP_020824229.1\|900604_900880_+	DUF4224 domain-containing protein	A0A0M3LNT7	Mannheimia_phage	1.2e-46	100.0
WP_006251368.1\|900839_901895_+\|integrase	tyrosine-type recombinase/integrase	A0A0M3LS39	Mannheimia_phage	2.8e-200	100.0
WP_006249908.1\|902042_903305_-	serine hydroxymethyltransferase	A0A240F3L3	Aeromonas_phage	6.9e-97	51.9
WP_006249906.1\|903580_903802_-	hypothetical protein	NA	NA	NA	NA
WP_006252134.1\|903889_904921_-	methionine synthase	NA	NA	NA	NA
WP_006252133.1\|905008_905986_-	DUF1852 domain-containing protein	NA	NA	NA	NA
WP_006252132.1\|906124_907009_-	NAD(+) kinase	NA	NA	NA	NA
WP_006249901.1\|908232_909045_+	inositol-1-monophosphatase	NA	NA	NA	NA
WP_006252130.1\|909089_910943_+	1-deoxy-D-xylulose-5-phosphate synthase	NA	NA	NA	NA
WP_006252129.1\|911128_912715_+	carbon starvation protein A	NA	NA	NA	NA
WP_006252128.1\|912775_913570_+	TatD family hydrolase	NA	NA	NA	NA
WP_006252127.1\|913560_914319_-	biotin ligase	NA	NA	NA	NA
WP_006252126.1\|914399_914966_+	biotin transporter BioY	NA	NA	NA	NA
WP_020824230.1\|915169_916519_+	MFS transporter	NA	NA	NA	NA
WP_006252121.1\|916685_918617_+\|tRNA	threonine--tRNA ligase	A0A2K9L297	Tupanvirus	1.8e-128	37.3
916604:916621	attR	NA	NA	NA	NA

DBSCAN-SWA_3

2167781 : 2216611

Mannheimia_phage(81.63%)

capsid,tail,protease,plate,transposase,terminase,head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020831168.1\|2167781_2168822_+\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	4.7e-192	94.5
WP_051138299.1\|2168945_2169506_+	hypothetical protein	NA	NA	NA	NA
WP_020831169.1\|2169486_2171418_+	DUF262 domain-containing protein	NA	NA	NA	NA
WP_006253059.1\|2171560_2171743_-	hypothetical protein	NA	NA	NA	NA
WP_080542692.1\|2171892_2172933_+	selenide, water dikinase SelD	NA	NA	NA	NA
WP_006248779.1\|2172932_2173406_+	NUDIX hydrolase	NA	NA	NA	NA
WP_006251194.1\|2173395_2174604_+	2-octaprenyl-6-methoxyphenyl hydroxylase	NA	NA	NA	NA
WP_006248781.1\|2174866_2176099_+	uracil-xanthine permease	NA	NA	NA	NA
WP_006251193.1\|2176165_2177152_+	dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_006248783.1\|2177192_2177603_-	DUF2251 domain-containing protein	NA	NA	NA	NA
WP_006251191.1\|2177668_2178979_-	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	6.8e-132	60.9
WP_020831176.1\|2179393_2180113_-	helix-turn-helix transcriptional regulator	F6MII3	Haemophilus_phage	2.6e-64	60.0
WP_020831178.1\|2180289_2180568_+	helix-turn-helix domain-containing protein	F6MII4	Haemophilus_phage	2.0e-17	58.8
WP_006251264.1\|2182494_2183376_+	AAA family ATPase	A0A0M3LP72	Mannheimia_phage	1.7e-155	99.3
WP_020831183.1\|2183386_2183635_+	hypothetical protein	NA	NA	NA	NA
WP_006251265.1\|2183644_2183965_+	hypothetical protein	A0A0M3LQH1	Mannheimia_phage	1.8e-41	90.3
WP_005822932.1\|2183967_2184159_+	hypothetical protein	A0A0M3LQK4	Mannheimia_phage	5.6e-27	95.2
WP_006251266.1\|2184171_2184789_+	DUF3164 family protein	A0A0M3LQ92	Mannheimia_phage	3.7e-112	99.5
WP_006251267.1\|2185107_2185320_+	ANR family transcriptional regulator	A0A0M3LSH0	Mannheimia_phage	1.9e-15	85.4
WP_032844828.1\|2185325_2185508_+	hypothetical protein	A0A0M3LSN0	Mannheimia_phage	5.0e-25	98.3
WP_006251269.1\|2185530_2186106_+	DUF5420 family protein	A0A0M3LP85	Mannheimia_phage	1.3e-98	93.2
WP_032848912.1\|2186118_2186487_+	hypothetical protein	F6MIJ4	Haemophilus_phage	1.5e-31	53.0
WP_006251271.1\|2186558_2186729_+	hypothetical protein	A0A0M3LPZ3	Mannheimia_phage	4.2e-26	92.9
WP_006251272.1\|2186728_2187283_+	hypothetical protein	A0A0M3LPP6	Mannheimia_phage	9.7e-96	98.4
WP_020831190.1\|2187266_2187689_+	regulatory protein GemA	A0A0M3LP80	Mannheimia_phage	3.3e-72	97.1
WP_020831192.1\|2188044_2188644_+	antA/AntB antirepressor family protein	A0A0R6PJV6	Moraxella_phage	8.7e-26	55.0
WP_006251275.1\|2188654_2188861_+	hypothetical protein	NA	NA	NA	NA
WP_006251276.1\|2188953_2189844_+	hypothetical protein	NA	NA	NA	NA
WP_006248646.1\|2190486_2191020_+	glycoside hydrolase family 108 protein	A0A0M3LSH2	Mannheimia_phage	5.6e-101	100.0
WP_020831193.1\|2191022_2191265_+	DUF2644 domain-containing protein	A0A0M3LSN9	Mannheimia_phage	3.2e-35	91.4
WP_020831194.1\|2191261_2191621_+	DUF2681 domain-containing protein	A0A0M3LP93	Mannheimia_phage	3.8e-53	86.6
WP_006251280.1\|2191635_2191791_+	hypothetical protein	A0A0M3LQ02	Mannheimia_phage	3.7e-21	96.1
WP_005606396.1\|2191783_2192041_+	hypothetical protein	A0A0M3LPQ4	Mannheimia_phage	9.5e-14	100.0
WP_005606393.1\|2192040_2192295_+	hypothetical protein	A0A0M3LP87	Mannheimia_phage	6.1e-29	100.0
WP_006251281.1\|2192302_2192803_+	DUF1804 family protein	A0A0M3LQI8	Mannheimia_phage	8.8e-80	97.0
WP_006251282.1\|2192802_2192949_+	hypothetical protein	A0A0M3LQM0	Mannheimia_phage	5.0e-20	93.8
WP_020831198.1\|2192952_2194578_+\|terminase	phage terminase large subunit	A0A0M3LQB7	Mannheimia_phage	0.0e+00	97.4
WP_020831201.1\|2194646_2196320_+	DUF935 domain-containing protein	A0A0M3LRU4	Mannheimia_phage	1.2e-298	92.8
WP_006251285.1\|2196306_2197596_+\|capsid	minor capsid protein	B7SDN5	Haemophilus_phage	2.1e-218	85.5
WP_006251286.1\|2197743_2198160_+	phage virion morphogenesis protein	A0A0M3LSP9	Mannheimia_phage	2.3e-70	96.4
WP_132303683.1\|2198156_2198375_-	hypothetical protein	NA	NA	NA	NA
WP_020831206.1\|2198418_2199486_+\|protease	phage protease	A0A0M3LPA7	Mannheimia_phage	1.1e-183	93.2
WP_006251289.1\|2199485_2200403_+\|head	Mu-like prophage major head subunit gpT family protein	B7SDP1	Haemophilus_phage	5.6e-149	84.9
WP_115262444.1\|2200448_2200766_+	hypothetical protein	A0A0M3LPR6	Mannheimia_phage	1.9e-27	90.8
WP_006248659.1\|2200765_2201191_+	DUF1320 domain-containing protein	A0A0M3LP98	Mannheimia_phage	4.0e-73	100.0
WP_006248660.1\|2201187_2201829_+	DUF1834 family protein	A0A0M3LQJ7	Mannheimia_phage	4.0e-117	100.0
WP_006248661.1\|2201829_2202009_+	DUF2635 domain-containing protein	A0A0M3LQM9	Mannheimia_phage	2.2e-25	100.0
WP_020831214.1\|2202008_2203418_+\|tail	phage tail sheath subtilisin-like domain-containing protein	A0A0M3LQC3	Mannheimia_phage	7.6e-254	99.4
WP_006251294.1\|2203428_2203803_+\|tail	phage tail protein	A0A0M3LRV6	Mannheimia_phage	3.3e-63	99.2
WP_006251295.1\|2203802_2204171_+	hypothetical protein	A0A0M3LSI2	Mannheimia_phage	1.0e-61	98.4
WP_006251296.1\|2204200_2204389_+	hypothetical protein	A0A0M3LSQ8	Mannheimia_phage	2.2e-28	100.0
WP_006251297.1\|2204441_2206721_+\|tail	phage tail tape measure protein	A0A0M3LPB6	Mannheimia_phage	0.0e+00	95.5
WP_006251298.1\|2206720_2208013_+	DNA circularization protein	A0A0M3LQ21	Mannheimia_phage	1.2e-232	95.6
WP_006248665.1\|2208015_2209143_+	hypothetical protein	A0A0M3LPS4	Mannheimia_phage	1.6e-209	99.7
WP_006253023.1\|2209147_2209795_+\|plate	phage baseplate assembly protein V	A0A0M3LPA3	Mannheimia_phage	6.0e-97	87.4
WP_020831216.1\|2209903_2210254_+	phage GP46 family protein	A0A0M3LQK5	Mannheimia_phage	1.2e-59	98.3
WP_020831218.1\|2210266_2211328_+\|plate	baseplate J/gp47 family protein	A0A0M3LQN4	Mannheimia_phage	1.7e-194	99.7
WP_006251302.1\|2211327_2211894_+	DUF2313 domain-containing protein	A0A0M3LQE1	Mannheimia_phage	1.9e-70	71.6
WP_020831220.1\|2211894_2214621_+	hypothetical protein	A0A0M3LS19	Mannheimia_phage	0.0e+00	90.6
WP_020824100.1\|2214621_2215245_+	DUF4376 domain-containing protein	A0A0M3LRX2	Mannheimia_phage	1.1e-111	97.1
WP_006252023.1\|2215237_2215702_+	hypothetical protein	F6MIM0	Haemophilus_phage	2.6e-54	63.0
WP_050412813.1\|2215822_2216611_+	hypothetical protein	F6MIM2	Haemophilus_phage	7.8e-107	68.7

DBSCAN-SWA_4

2463765 : 2470550

Mycobacterium_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_031200389.1\|2463765_2464548_+	alpha/beta fold hydrolase	G1DB77	Mycobacterium_phage	1.3e-05	36.4
WP_006252001.1\|2464557_2465286_+	carboxy-S-adenosyl-L-methionine synthase CmoA	H9YRL8	environmental_Halophage	1.2e-21	29.1
WP_006248949.1\|2465421_2466441_+	HTH-type transcriptional repressor PurR	C6ZCU4	Enterobacteria_phage	1.9e-33	32.9
WP_006248950.1\|2466442_2467045_+	DedA family protein	NA	NA	NA	NA
WP_006248951.1\|2467173_2467329_-	DUF1328 domain-containing protein	NA	NA	NA	NA
WP_006248952.1\|2467406_2467988_-	dCTP deaminase	I4AZP2	Saccharomonospora_phage	5.9e-27	38.4
WP_006248953.1\|2468002_2468650_-	uridine kinase	A0A1V0SAA3	Catovirus	4.7e-33	36.6
WP_006248954.1\|2468753_2469383_+	amino acid transporter	NA	NA	NA	NA
WP_006248955.1\|2469497_2470550_+	rod shape-determining protein	F2Y2E1	Organic_Lake_phycodnavirus	1.2e-06	22.1

Anti-CRISPR protein detection

Acr_ID: NC_021738.1|WP_006251271.1|2186558_2186729_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NC_021738.1|WP_006251272.1|2186728_2187283_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_021738.1|WP_006251271.1|2186558_2186729_+|hypothetical-protein

2186558_2186729_+

56 aa aa

2167781-2216611

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_021738_3	Orphan	3.1\|967462\|50\|NC_021738\|CRISPRCasFinder	967462-967511	50	2168802-2168851	0

1. spacer 3.1|967462|50|NC_021738|CRISPRCasFinder matches to NC_021738 position: 2168802-2168851, mismatch: 0

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	Protospacer
**************************************************

NC_021738.1|WP_006251272.1|2186728_2187283_+|hypothetical-protein

2186728_2187283_+

184 aa aa

2167781-2216611

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_021738_3	Orphan	3.1\|967462\|50\|NC_021738\|CRISPRCasFinder	967462-967511	50	2168802-2168851	0

1. spacer 3.1|967462|50|NC_021738|CRISPRCasFinder matches to NC_021738 position: 2168802-2168851, mismatch: 0

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	Protospacer
**************************************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_021738

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information