CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021872	Lactobacillus reuteri TD1, complete sequence	1 crisprs	cas14j,cas3,DEDDh,RT,DinG,csn2,cas2,cas1,csa3	0	3	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_021872_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021872_1

1286441-1286805

TypeV,TypeII-A

Consensus_repeat	Method
NNNNNNNNNTTCTANNAACATTATTGATTTGAAGTACATCTAAAAC	CRT
GTTCTAAACATTATTGATTTGAAGTACATCTAAAAC	PILER-CR
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC	CRISPRCasFinder

5 spacers

cas14j,csn2,cas2,cas1

The CRISPR arrays of NC_021872_1

>merge|NC_021872|1|1286441-1286805|CRT,PILER-CR,CRISPRCasFinder
AGCCGTGAGTTCGACTAATATTTATCATCTAAAATCTTCATTGGAGTTCCAGGACATCTTCCCAGATTCTAAACATTATTGATTTGAAGTACATCTAAAACGGAGGTATTACATGAATGCACAATAATCTAGTTCTAAACATTATTGATTTGAAGTACATCTAAAACTGGGGTGGCAACGAAATCTTGTGGTACGTAGTTCTAAACATTATTGATTTGAAGTACATCTAAAACAGTTGGCTCTTGCTTATAAACATTAAAGGTGTTCTAAACATTATTGATTTGAAGTACATCTAAAACCAACTTGAGTAGTAATTGCCGAGCCTCCTAGTTCTAAACATTATTGATTTGAAGTACATCTAAAAC

>NC_021872|1|1|1286441-1286805|CRT
AGCCGTGAGTTCGACTAATATTTATCATCTAAAAT	CTTCATTGGAGTTCCAGGACATCTTCCCAGA
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC	GGAGGTATTACATGAATGCACAATAATCTAG
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC	TGGGGTGGCAACGAAATCTTGTGGTACGTAG
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC	AGTTGGCTCTTGCTTATAAACATTAAAGGTG
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC	CAACTTGAGTAGTAATTGCCGAGCCTCCTAG
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC

>NC_021872|1|1|1286507-1286805|PILER-CR
TTCTAAACATTATTGATTTGAAGTACATCTAAAACG	GAGGTATTACATGAATGCACAATAATCTAG
TTCTAAACATTATTGATTTGAAGTACATCTAAAACT	GGGGTGGCAACGAAATCTTGTGGTACGTAG
TTCTAAACATTATTGATTTGAAGTACATCTAAAACA	GTTGGCTCTTGCTTATAAACATTAAAGGTG
TTCTAAACATTATTGATTTGAAGTACATCTAAAACC	AACTTGAGTAGTAATTGCCGAGCCTCCTAG
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC

>NC_021872|1|1|1286507-1286805|CRISPRCasFinder
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC	GGAGGTATTACATGAATGCACAATAATCTAG
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC	TGGGGTGGCAACGAAATCTTGTGGTACGTAG
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC	AGTTGGCTCTTGCTTATAAACATTAAAGGTG
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC	CAACTTGAGTAGTAATTGCCGAGCCTCCTAG
TTCTAAACATTATTGATTTGAAGTACATCTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021872.1\|WP_020843139.1\|1271844_1272723_-\|metallophosphoesterase-family-protein	unknown	unknown	gnl\|CDD\|378975
NC_021872.1\|WP_019253817.1\|1274841_1275741_-\|prenyltransferase	unknown	unknown	gnl\|CDD\|235695
NC_021872.1\|WP_019253821.1\|1281850_1283773_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|273270
NC_021872.1\|WP_080651460.1\|1288809_1290228_+\|ISLre2-family-transposase	unknown	unknown	gnl\|CDD\|284250
NC_021872.1\|WP_019253824.1\|1286833_1287505_-\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
NC_021872.1\|WP_019253312.1\|1296333_1296666_-\|MazG-like-family-protein	unknown	unknown	gnl\|CDD\|212147
NC_021872.1\|WP_019253311.1\|1295503_1296331_-\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197321
NC_021872.1\|WP_019253820.1\|1279822_1281841_-\|beta-galactosidase	unknown	unknown	gnl\|CDD\|367090
NC_021872.1\|WP_019253825.1\|1287501_1287807_-\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
NC_021872.1\|WP_019253819.1\|1276870_1279603_-\|PT-domain-containing-protein	unknown	unknown	gnl\|CDD\|274008
NC_021872.1\|WP_020843141.1\|1274097_1274799_+\|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	unknown	unknown	gnl\|CDD\|234689
NC_021872.1\|WP_019253310.1\|1294822_1295302_+\|hypothetical-protein	unknown	unknown	unknown
NC_021872.1\|WP_019253313.1\|1296815_1297040_+\|hypothetical-protein	unknown	unknown	unknown
NC_021872.1\|WP_019253316.1\|1298676_1299588_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|119379
NC_021872.1\|WP_019253826.1\|1287784_1288693_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NC_021872.1\|WP_019253818.1\|1275821_1276802_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|173833
NC_021872.1\|WP_020843140.1\|1272841_1274077_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340949
NC_021872.1\|WP_019253823.1\|1285101_1286265_-\|transposase	cas14j	-	gnl\|CDD\|223747
NC_021872.1\|WP_029507521.1\|1283931_1284951_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380486
NC_021872.1\|WP_019253315.1\|1298276_1298420_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021872.1\|WP_020843139.1\|1271844_1272723_-\|metallophosphoesterase-family-protein	gnl\|CDD\|378975	pfam12850, Metallophos_2, Calcineurin-like phosphoesterase superfamily domain. Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	2.39121e-11
NC_021872.1\|WP_019253817.1\|1274841_1275741_-\|prenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	1.87993e-102
NC_021872.1\|WP_019253821.1\|1281850_1283773_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|273270	TIGR00792, Melibiose_carrier_protein, sugar (Glycoside-Pentoside-Hexuronide) transporter. The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	2.46975e-128
NC_021872.1\|WP_080651460.1\|1288809_1290228_+\|ISLre2-family-transposase	gnl\|CDD\|284250	pfam06782, UPF0236, Uncharacterized protein family (UPF0236).	1.07293e-34
NC_021872.1\|WP_019253824.1\|1286833_1287505_-\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	2.01149e-79
NC_021872.1\|WP_019253312.1\|1296333_1296666_-\|MazG-like-family-protein	gnl\|CDD\|212147	cd11540, NTP-PPase_u3, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea. This family corresponds to a group of uncharacterized hypothetical proteins from bacteria and archaea, showing a high sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, members in this family consist of a single MazG-like domain that contains a well conserved divalent ion-binding motif EXX[E/D].	1.73394e-26
NC_021872.1\|WP_019253311.1\|1295503_1296331_-\|exodeoxyribonuclease-III	gnl\|CDD\|197321	cd09087, Ape1-like_AP-endo, Human Ape1-like subfamily of the ExoIII family apurinic/apyrimidinic (AP) endonucleases. This subfamily includes human Ape1 (also known as Apex, Hap1, or Ref-1) and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Ape1 and Ape2 in humans. Ape1 is found in this subfamily, it exhibits strong AP-endonuclease activity but shows weak 3'-5' exonuclease and 3'-phosphodiesterase activities. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes exonuclease III (ExoIII) and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	2.92439e-120
NC_021872.1\|WP_019253820.1\|1279822_1281841_-\|beta-galactosidase	gnl\|CDD\|367090	pfam02449, Glyco_hydro_42, Beta-galactosidase. This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	0
NC_021872.1\|WP_019253825.1\|1287501_1287807_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.69095e-26
NC_021872.1\|WP_019253819.1\|1276870_1279603_-\|PT-domain-containing-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	6.9028e-13
NC_021872.1\|WP_020843141.1\|1274097_1274799_+\|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	gnl\|CDD\|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	7.84549e-113
NC_021872.1\|WP_019253316.1\|1298676_1299588_-\|SH3-domain-containing-protein	gnl\|CDD\|119379	cd06417, GH25_LysA-like, LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase family 25 (GH25) domain of LysA has sequence similarity with other murein hydrolase catalytic domains while the C-terminal domain has sequence similarity with putative bacterial cell wall-binding SH3b domains. This domain family also includes LysL of Lactococcus lactis.	8.62655e-96
NC_021872.1\|WP_019253826.1\|1287784_1288693_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.52875e-94
NC_021872.1\|WP_019253818.1\|1275821_1276802_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	1.17545e-72
NC_021872.1\|WP_020843140.1\|1272841_1274077_+\|MFS-transporter	gnl\|CDD\|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.37432e-137
NC_021872.1\|WP_019253823.1\|1285101_1286265_-\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.19893e-42
NC_021872.1\|WP_029507521.1\|1283931_1284951_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380486	cd01544, PBP1_GalR, ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism. Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism. Transcription of the galactose regulon genes is regulated by Gal iso-repressor (GalS) and Gal repressor (GalR) in different ways, but both repressors recognize the same DNA binding site in the absence of D-galactose. GalR is a dimeric protein like GalS and is exclusively involved in the regulation of galactose permease, the low-affinity galactose transporter. GalS is involved in regulating expression of the high-affinity galactose transporter encoded by the mgl operon. GalS and GalR are members of the LacI-GalR family of transcription regulators and both contain the type 1 periplasmic binding protein-like fold. Hence, they are structurally homologous to the periplasmic sugar binding of ABC-type transport systems.	5.04727e-85

>NC_021872.1|WP_019253823.1|1285101_1286265_-|transposase
MDQIIKGVKLRLYPNRGQKDKLWQMFGNDRFVWNQMLSMAKTRYQNNPRASFINGYGMDTLLKVLKNEYPFLKESDSTSLQVVNHKLNQSFQMLFKHRGGYPRFKSRKATKQAYTGKSKVSVVAKRCLKLPKIGYIKTSKTNQLVDTKIKRYTVSYDATGRYYLSLQVEVPAPELLPKTGKVVGLDVGLADLAISSDGVKYGTFNAKWLDKQVNKWQSAYAKRKYRATIAVRQWNHNHKTVKEELNDYQNWQRARRYKARYQAKVANKRQDNLQKLTTELVKQYDVIVIEDLKTKNLQKNHHLAKSIANASWYQLRTMLEYKCAWYGRQLIIVKPNYTSQICSSCGYHNGPKPLKIREWTCSKCGVHHDRDINAAINILHKGLKANG
>NC_021872.1|WP_029507521.1|1283931_1284951_-|LacI-family-DNA-binding-transcriptional-regulator
MATIKEIAEKSGYSPATVSRLLNNDQNLSISPSTRNKIMTVANELGYWNNHKKNSQQQPIRPNLALLYRVSGKEQLQDEYFAFLRNAIIKEVDEAGAQVEIFSNIKDLIAAADSFQGFIGVGADRVTQDQLIELHQYLPHGVFVDINPMPQLFDSVQPNLELTIQDALRRLTEAGYERIGFIGGKGLNLNNVQQADAREIAFREFTGMQGIEEAPLYVDGPFNVKNGYQLGKRVLEQSGGNLPEAFIIASDTLSVGVLQAFNEAGVIVPRDTVVISINNSEVAKYVSPPLTSYDINQETLSRMAINLLQDLITHPQRPHVHLTVNTDIVFRKSFPKENK
>NC_021872.1|WP_019253821.1|1281850_1283773_-|PTS-sugar-transporter-subunit-IIA
MTHSHKLTGKQLISRASFCFGNLGHSAFYGVMSTYFIIFVTSGMFAGLSKTVANKLIGLITGLIVSVRILELLIDPLLGNIVDNTKTRWGKFKPWILMGNIVSAILLLILFTGIFGLAKYNWVLFAILFVIVFVTFDIFYSFSDVSYWGMVPALSEDSEERGVYTALGAFAGTLGWNGLTIIVVPIVTTFTYLATGHHRQGPAGWFAFAAIISALAVICALVVCVGTKENYNVIRKSAQDKTTIREVFSAIFHNDQILWPSLAYLLYSCAYVVTNGVLFYLYKFVIGKPGEFWIVGVIATIIGFCTSPLYPILNKFIPRKWLFIGGQVCMSLAYLIFIFARSNVLMMDFGLVLFNINFAQLVTVLTLTDAIEYGQLKSGQRNEAVVLAVRPMIDKLTGAISNGLVGYIAIAAGMTGSATAADMTGHDIRTFDSMAFYIPLALAVLSIFVFLFKVKLSEEVHAEVVEELKDKLAQGELTSEESTSSTGLKEETIYAPTDGELVAMKEVVDRDGQPFPGKGFAIKPTSDKLYAPFDGKINFTFGTRHAFGITSDKGLEMIVHIGVGTVNMRGEGFNAHYNDGQIVKKGQLLFDFDRELIKRSGYEDWVITFFAQPHNIEATAGFTPGKLVKHGDKVVTVEFK
>NC_021872.1|WP_019253820.1|1279822_1281841_-|beta-galactosidase
MMKRELPHFLYGGDYNPEQWPEETWAEDIKVFKQADINSATINVFSWALLEPQEGKYDFTKLDKIIKELMAADFDIVLATSTAAMPAWMFKKYPDVARVDYQGRRHVFGARHNFCPSSKNYRRLAKNLVEQLAKRYSGNPHIVAWHVNNEYGGNCYCEECQTEFQQWLKARYQSLDNLNHAWNMNVWSHTIHDWDEIVVPNELGDAWGPEGSETIVAGLSIDYLRFQSTQMLDLFKMEKRIIEKYDPTTLVTTNFHSLPNKMIDYQQWASAQDIISYDSYPAYDAPVYQPAFLYDLMRSLKHQPFMLMESTPSQVNWQPYSPLKRPGQMAATELQAVAHGADTVQFFQLKQALGGSEKFHGAVISHANRTDTRAFKEVAKLGHDLRKVGPVIKNSQTKARVALIFDWSNFWSFEYVDGITQDLKYVPIILDYYRQFYELNIPTDVISVDDDFSQYDLVVAPVFYMVKDGLGKKITDYVANGGNFITSFMSGMVNESDNIYPGGYPGPLKDVMGLWVEESDAILPDKDVKLAMTTGDELTGHLIADLIRLKGARVLAKYASEFYAGTPAVTENTYSKGKTWYVGSRLDHASLRKIIMHIIDDVHLSALVKERTELEITKRQNSAGQNIYFVLNMGKGKQPLPVEFQKGYRDLLTGDSPETMLDSWDVEILVQG
>NC_021872.1|WP_019253819.1|1276870_1279603_-|PT-domain-containing-protein
MKKLRYTSIAVATLAAATLASANNKVSADVTNNNTVIAGLDKQTVQDAVSNAQNMVNNAQSNVNIKEQALSDAQGKAQTANNAYTTQQSKLTDSQKNLANKQDAVKQAQNNLDNAEKLAQQATPENIKQAQKNITDQQKVIQNAQGNVNAANTELNKAQGQLNNAKQKQADAQKLVNDKNLAKQDADNNVSKAEADVKNSGLNEAEQNVQKVQTTLDNIKKTNSSNESVLKQNQTALADNKKKIADLNNKIDAAKKNVADAQNNVKDKQQALATAQKALSDLQDQVAQDQASGAAGFFKAIADNKDNSESLREDAQTAYNIITGQPNAYQDITVEWAKKAVDLGQEKDSTSLNNIEKALGYYQHWMTYRDKYGLSHPSISLTAVAIAMLSSDFQHYSDEFNHPILLTAKYGPFYEDEEDISAGDVNPIDNWMSEKADIDNYIKDHPDAATYSFESNYPLTQDEWEKDVDFWKDKPVYIGHYTSMIKPDANYVGLAGNEYEIQPLMNNADSMDEIIFNPVNGMDFDSYQDLVHSYLQNVKQEDKIKTLNANVVTANQNLTNAQNAVKSAQNNVQSLQSNLAELNNSSDKINKAISDTQVALAKGQENLEFEQKQLDQANQTLADVQAKVGTKAKALDDAKAAQSKAVEALSQVQKALDETNDEVKVAQSSVDAAQNNLNTKNNDLKNAQNKLTALNQTLSNLENSKTNLEKAQKALDNANDEALQATKDVDAQQSIMSSLKKNKEKADAQVITAIEKLKQAQSDLTVAQGRLAAEQEAQKDNQPTAQPTVQPSEQPTAQPTEQPTSQPSEQPTAQPTEQPTSQPAIESNTQLPGEQKNEEPQPMTTQVTTKKGKTSIVEPTNSSSTQPTTKQGAQQLPQTGNQKSSSLIGLSFAGLLSALGLTKVNKKRKD
>NC_021872.1|WP_019253818.1|1275821_1276802_+|polyprenyl-synthetase-family-protein
MKQHFFHTYPAINNALGKVNQTINDRITIKNTQLHDALQQMASNGGKYLRPAFFLLFANINHQTVAEQEKLIKIASSLEVLHMATLIHDDIIDDSPKRRGAVSVQAAFGKDTAVYTGDFLFTIFFDLLVETMTGSPYLTRNARTMRKILTGELGQMDNRFDLDQSLLDYYRNVNGKTAAIFSLAAEEGAYFGHGDRRTINLAKRIGQNIGISFQILDDILDYSGDERLNKPVLEDLATGVYSLPLLLTLQNHRHELEPLLAKKRQMTIEDMEKAQKIVVTHGGVKKAQEIATKFTQKAQTEIDQLADKHTRKMLKLVADKLLTRVN
>NC_021872.1|WP_019253817.1|1274841_1275741_-|prenyltransferase
MSLNVFLELVEIKAKTASILPMLLGVCLSVYYYHSLNLLNSVLFFIAMLLFNMAVDMMDNYNDYNHAIDTVDYKKNTNIIGRENISPRLVLGLLLAFSIVAGLIGIYLVTRVGLPLLWMGIFCFAIGILYSSGPFPLSGLPVGEFASGFTMGFMITLISVFINVGPQFTWSWANIGVVFLVALPDELWISNLLLANNICDAGEDEDNRRHTVIHFIGQKKGLYAFAIKNVLAFLAIIFAVVLHFTPWTVLLTLLIIPFVVKQTRMLFAKQVKKETFPCAVKILLIGSLVQVVTFAIGLI
>NC_021872.1|WP_020843141.1|1274097_1274799_+|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE
MVQTNKLLNEHEVNNLFSRVAPRYDLLNNVISLGTQKIWRHEIFNQLQIKPTDNALDVCCGTGDLAIALAKRISSGRVTGLDFNKEMLEIANEKTKMIGNLFLVQGDAMALPFDDNSFDIVTIGFGLRNVPDANKALSEIYRVLKPGGQFVSLEMSQPTNPIIKVGWKAYFTAFPLMASLAGGHYRDYQYLKKTSQQFVSAHQLARMMKAVGFKEVHYQPLNFGAAALHFGNK
>NC_021872.1|WP_020843140.1|1272841_1274077_+|MFS-transporter
MIIKMDSEVARGKFPHGWHRTFYTLWLGAFITGMGYSMTMPFISLFIAELGNFTRFQLNIYSGLAFGVTFISQAIVSPFWGSLADRKGRKLMCMRASGVMACTICAIGFAQSVWMIIGMRFLQGVFSGYINNATALMAGETPHNKSGWVMSAMTTAGVAGNLVGPLLGGFLSGLFGYRIPFFITGALMFCVFLSTWLLTVEHFTPIKKEAMKPMKEIIHNLDNPPLIFAMFLTTMIVTSSTMSIDPIISLYVRQLMGGHGNIAFVAGIVAATPGLGTLLAASKVGHTMDRIGPEKVLQIGILTAFILFIPMTITKSPWALAFWRFLLGLANAALMPATQTVLTLDVPTEAFGRIFSYNQSFQAAGAVLGSILGSFISGISSYEMVFVITGLTLLLNFILVMLVRPKKQLTE
>NC_021872.1|WP_020843139.1|1271844_1272723_-|metallophosphoesterase-family-protein
MKIRKGKSSVKKRIAVFSDTHGNLTALQAMYRDSLAQHVDEYWFIGDLLMPGPSVKPIWEILQEMKPAVIVRGNWDDLVVRGARGMMDMERPSHIYFARLAQYVAEHAPDGMVDEIASWPMHVTKRVGPLNFGISHNLPWLNMGQDLFPTQVSENFDKLFNVAGEPVDVAIYAHVHHDLLRYGSDERMVLNPGAVGEPFNHWQPLQRDLRAHYLILEVDDIGLAETSFRHIGYSRDQEKQIADKSDLPYRDLYKKMMVTGRAYTHDDDLLTEYNNQYNYADEYRKYAKKLNG
>NC_021872.1|WP_019253824.1|1286833_1287505_-|type-II-A-CRISPR-associated-protein-Csn2
MKLVYKGHPPVQIDKGKFTVLATNNRKTYFELIRGLQGFNDRLTILDDDYQDLDPEKAIDWDGDLVANNNLATIYSTEIVKSIIKNLTEEDRHLLDAEARRLYSNVQEILFMTDLPLEVRYDGDIKRLLNYCKIKFSPLVQQSPYDIIKTDLKLHLECADSSCVGLSNVANYLDSAQFNELQQLNIELKIPVLLIEFTEIDNRKYYGNADFYYIDKDFVDWKL
>NC_021872.1|WP_019253825.1|1287501_1287807_-|CRISPR-associated-endonuclease-Cas2
MRLLIMFDLPVETSKERREYRQFRKRLINEGFLMIQYSVYVRVCVNKKSAQFIEKRISTFLPETGTIQSMIMTEKQYNDMHFLLGESSKDVRNLSGRTIIL
>NC_021872.1|WP_019253826.1|1287784_1288693_-|type-II-CRISPR-associated-endonuclease-Cas1
MGWRSVIVTQHAKLSYTSHLMVVQTNDGINQIPIEDIELLLVSTTQAVITSALLSELAKREAKVIFVDNTLQPICETVSYYPNNRSYELIENEFHWAKHRKEILWTKIVAAKIINQLQVLDIYGHDISLISDELNQLELNDETNREAVVARKYFPLLFENEKFSRRSMTAVNAALNYGYSILLSTINRAIVTKGYLTQLGIHHQNTENQFNLGSDLMEPFRPVIDYWVANQNFTELTPDVKFGLVDSLNLEITFNDKKMLVRNAINLYVSQCLNYLSEKSKEIKIEMKFNNEVPNNALINHV
>NC_021872.1|WP_080651460.1|1288809_1290228_+|ISLre2-family-transposase
MCRILSKGRSFLMDILTEIEQNLVKSGSLFEAEQIILKGVLELGQAIMQNFLESLDRNLKSQTPANYQVINKQPRTLNFIFGPVTFRRRYYQAGTKKREFYLDQQLKIKPRRRLSPHYLMMMAKIAQTTTMRNTADILNLVFDSGITADSVMHAVHELGNQVAEQTQVKERQTTHRRTPRNLTIEGDAFMIKLKKEAGQLTLVHHYRVYERVANQIINRHDFLSVGHQGRLESRLSDYLDRHYKLAGQTIFLASDAGPGYEPAKLLSLVPQGAHGEYFLDRYHCLQKIEHTLGQHNELAMRAIKAVRHHDQAELAIILDTYESQNLTEKQADDLMRLRKYLQRNWQYILSPQMRGFKDIHLIGSVESSHRTFTYRMKKQGKSWTEQGAKAMIGLIEARMNGELQASLNTILKQLTVLPRAAQTGLLQEMHIRTGEFLRKAPTKPSIGAVQGIIPINTATSRPMGQLFKALTH
>NC_021872.1|WP_019253310.1|1294822_1295302_+|hypothetical-protein
MNKVSKGLVLALAGITVGTSTGLSTTFFQSTSVAYAAEMTKEKNDLANRYIADYLGNCQQYEQNDKTFKGFSSIKDITYSRDNKIKIDVNDDIYQLPKARRSLLIQDLQNGVYGTLADNDLKKLSEKDIQKGCPTTVYLNGKVIGHTAKNDNHHIIWDK
>NC_021872.1|WP_019253311.1|1295503_1296331_-|exodeoxyribonuclease-III
MKFISWNIDSINAALTGTSVRAGETREVLKKIAAMKPDVIAIQETKLSKNGPTKKHLTVLQELFPNYEVAWRSSVEPARKGYAGTMYLYLAQYEPKVTYPKINAPEPMDDEGRIITLEFPDFYVTEVYTPNSGNELKRLDERQTWDDCYRDYLHELDQQKPVIASGDFNVAHEEIDLAHPATNHHSAGFTDEERTHFSKLLAAGFTDSFRHLHPDEKGVYSWWAQRVITSKQNNSGWRIDYWLVSDRLADKITEAGMIDSGERRDHTPIILEIDL
>NC_021872.1|WP_019253312.1|1296333_1296666_-|MazG-like-family-protein
MNYEDLFQKIDEWAHERGIDHADPRVEFMKMAEELGELSSAYNKENQTKLIDSIGDLQIALLIFCKLVGVDHQQALTAAYQEIAKRTGKTTADGVFIKESDLKSRNKKEK
>NC_021872.1|WP_019253313.1|1296815_1297040_+|hypothetical-protein
MDLTNYRIDPAKFALACVQSSPDLTTEDKLRVYKEAYEEALTFYHQIQTAVINKGRSKEDRSLKEMGDFFDLKN
>NC_021872.1|WP_019253315.1|1298276_1298420_+|hypothetical-protein
MFNPLSGLAKIVEAMHGLSQLVQLALIGLIGFAILCMTIVAIICHLN
>NC_021872.1|WP_019253316.1|1298676_1299588_-|SH3-domain-containing-protein
MLKMVDVFSGSPRSFATLPETDITMVKATQGTGYVNPACNIDYANAKAAGKLLGLYHYCAGGNPIAEADYFINNIKNYVGEAVLAVDWEGYQNSSWGNYNYVRQFVNRVHELTGVWCMVYVSQSEIRQVANCVNDCPLWVAYYKYSQPLNWDYQGAGFNIAPWEVFTIHQFTGSDMDRNMVNTTKEGWLKMANPNNNISIPEPSPIQPVEEHKDEKEVSFVDELGDTWFKEDGKFTLDVAVNLRYGARTTSDIITTLPAGSTIKYDAFSRHAGYVWIRQPRENGYGYMAVRDAKTNQPFGKFE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021872_1	1.1\|1286476\|31\|NC_021872\|CRT	1286476-1286506	31	NZ_CP041677	Lactobacillus reuteri strain LL7 plasmid unnamed, complete sequence	110812-110842	1	0.968
NC_021872_1	1.1\|1286476\|31\|NC_021872\|CRT	1286476-1286506	31	NZ_CP030090	Lactobacillus reuteri strain YSJL-12 plasmid unnamed1, complete sequence	32973-33003	2	0.935
NC_021872_1	1.1\|1286476\|31\|NC_021872\|CRT	1286476-1286506	31	NC_042091	Pseudomonas phage nickie, complete genome	8537-8567	6	0.806
NC_021872_1	1.6\|1286543\|30\|NC_021872\|PILER-CR	1286543-1286572	30	NZ_CP011133	Citrobacter amalonaticus Y19 plasmid unnamed, complete sequence	40215-40244	8	0.733
NC_021872_1	1.2\|1286542\|31\|NC_021872\|CRT,CRISPRCasFinder	1286542-1286572	31	NZ_CP011133	Citrobacter amalonaticus Y19 plasmid unnamed, complete sequence	40214-40244	9	0.71

1. spacer 1.1|1286476|31|NC_021872|CRT matches to NZ_CP041677 (Lactobacillus reuteri strain LL7 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.968

cttcattggagttccaggacatcttcccaga	CRISPR spacer
cttcattggagttccaggacatcttcccagt	Protospacer
******************************

2. spacer 1.1|1286476|31|NC_021872|CRT matches to NZ_CP030090 (Lactobacillus reuteri strain YSJL-12 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.935

cttcattggagttccaggacatcttcccaga	CRISPR spacer
cttcattggagctccaggacatcttcccagt	Protospacer
***********.******************

3. spacer 1.1|1286476|31|NC_021872|CRT matches to NC_042091 (Pseudomonas phage nickie, complete genome) position: , mismatch: 6, identity: 0.806

cttcattg--gagttccaggacatcttcccaga	CRISPR spacer
--tgatggacgagttccaggacatccgcccaga	Protospacer
  * ** *  ***************. ******

4. spacer 1.6|1286543|30|NC_021872|PILER-CR matches to NZ_CP011133 (Citrobacter amalonaticus Y19 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ggaggtattacatgaatgcacaataatcta	CRISPR spacer
acttgcattaagtgaatgcacaataatctt	Protospacer
.   *.**** .*****************

5. spacer 1.2|1286542|31|NC_021872|CRT,CRISPRCasFinder matches to NZ_CP011133 (Citrobacter amalonaticus Y19 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.71

ggaggtattacatgaatgcacaataatctag	CRISPR spacer
acttgcattaagtgaatgcacaataatcttt	Protospacer
.   *.**** .*****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

950687 : 958752

Staphylococcus_phage(33.33%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020843076.1\|950687_950963_+	HU family DNA-binding protein	A7KV42	Bacillus_phage	1.3e-24	69.7
WP_003674239.1\|951099_952365_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_019254038.1\|952490_953702_+\|tRNA	CCA tRNA nucleotidyltransferase	G3MAR3	Bacillus_virus	3.8e-36	39.7
WP_020843077.1\|953703_955614_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	8.0e-57	30.6
WP_020843078.1\|955631_956594_+	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	1.8e-113	60.6
WP_003666061.1\|956609_957098_+	dihydrofolate reductase	A0A1B2IBQ4	Erwinia_phage	4.3e-23	40.8
WP_003666062.1\|957086_957731_-	hemolysin III family protein	NA	NA	NA	NA
WP_019251613.1\|957909_958752_+	DegV family protein	A0A0N9SI50	Staphylococcus_phage	8.0e-17	34.1

DBSCAN-SWA_2

1285101 : 1339578

Lactobacillus_phage(29.41%)

capsid,integrase,portal,plate,terminase,transposase

attL 1335103:1335118|attR 1345083:1345098

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_019253823.1\|1285101_1286265_-\|transposase	transposase	Q5ULQ4	Lactobacillus_virus	1.4e-152	68.5
WP_019253824.1\|1286833_1287505_-	type II-A CRISPR-associated protein Csn2	NA	NA	NA	NA
WP_019253825.1\|1287501_1287807_-	CRISPR-associated endonuclease Cas2	NA	NA	NA	NA
WP_019253826.1\|1287784_1288693_-	type II CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_080651460.1\|1288809_1290228_+\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_019253310.1\|1294822_1295302_+	hypothetical protein	NA	NA	NA	NA
WP_019253311.1\|1295503_1296331_-	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	2.6e-97	62.6
WP_019253312.1\|1296333_1296666_-	MazG-like family protein	M5AWB2	Nitratiruptor_phage	1.5e-14	41.2
WP_019253313.1\|1296815_1297040_+	hypothetical protein	NA	NA	NA	NA
WP_019253315.1\|1298276_1298420_+	hypothetical protein	NA	NA	NA	NA
WP_019253316.1\|1298676_1299588_-	SH3 domain-containing protein	Q9AZ81	Lactobacillus_prophage	1.9e-96	56.7
WP_019253317.1\|1299589_1299946_-	hypothetical protein	NA	NA	NA	NA
WP_019253318.1\|1299932_1300097_-	hypothetical protein	A0A0A1ENA2	Lactobacillus_phage	4.2e-07	54.9
WP_019253319.1\|1300101_1300479_-	hypothetical protein	A0A0A1ENR5	Lactobacillus_phage	3.5e-41	60.8
WP_019253320.1\|1300490_1300649_-	hypothetical protein	NA	NA	NA	NA
WP_019253321.1\|1300641_1300899_-	hypothetical protein	NA	NA	NA	NA
WP_144063117.1\|1300912_1302484_-	hypothetical protein	H7BVG0	unidentified_phage	1.1e-59	37.3
WP_019253323.1\|1302502_1303264_-	hypothetical protein	A8ATI3	Listeria_phage	6.3e-13	30.4
WP_019253324.1\|1303260_1304487_-\|plate	baseplate J/gp47 family protein	A8ATI2	Listeria_phage	1.5e-56	33.7
WP_019253325.1\|1304479_1304812_-	hypothetical protein	NA	NA	NA	NA
WP_019253326.1\|1304798_1305164_-	hypothetical protein	NA	NA	NA	NA
WP_019253327.1\|1305167_1306031_-	hypothetical protein	A8ATH9	Listeria_phage	4.9e-38	35.2
WP_019253328.1\|1306023_1306359_-	hypothetical protein	D6PSZ5	Lactobacillus_phage	2.9e-26	50.9
WP_019253329.1\|1306358_1306922_-	LysM peptidoglycan-binding domain-containing protein	A0A1L2JY61	Aeribacillus_phage	8.8e-20	36.9
WP_019253330.1\|1306924_1312063_-	hypothetical protein	E9LUR1	Lactobacillus_phage	5.4e-07	22.3
WP_019253331.1\|1312055_1312256_-	hypothetical protein	A8ATH5	Listeria_phage	3.3e-06	55.6
WP_019253332.1\|1312242_1312572_-	hypothetical protein	NA	NA	NA	NA
WP_019253333.1\|1312656_1313055_-	hypothetical protein	NA	NA	NA	NA
WP_019253334.1\|1313068_1314172_-	DUF3383 family protein	A8ATH2	Listeria_phage	3.4e-52	34.6
WP_019253335.1\|1314168_1314636_-	hypothetical protein	NA	NA	NA	NA
WP_100068885.1\|1314619_1314982_-	hypothetical protein	NA	NA	NA	NA
WP_019253337.1\|1314999_1315434_-	hypothetical protein	Q7Y5T8	Haemophilus_phage	7.8e-08	34.8
WP_019253338.1\|1315442_1315787_-	hypothetical protein	NA	NA	NA	NA
WP_019253339.1\|1315767_1315968_-	hypothetical protein	NA	NA	NA	NA
WP_019253340.1\|1315967_1316936_-\|capsid	N4-gp56 family major capsid protein	Q79S85	Temperate_phage	3.2e-62	46.0
WP_019253341.1\|1316936_1317578_-	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_019253342.1\|1317687_1317870_-	hypothetical protein	NA	NA	NA	NA
WP_019253343.1\|1317866_1319282_-	hypothetical protein	NA	NA	NA	NA
WP_019253344.1\|1319232_1320669_-\|portal	phage portal protein	A0A097PAT2	Streptococcus_pyogenes_phage	6.4e-67	35.2
WP_019253345.1\|1320669_1321962_-\|terminase	PBSX family phage terminase large subunit	Q6SE84	Lactobacillus_prophage	2.2e-167	67.6
WP_019253346.1\|1321942_1322761_-\|terminase	terminase small subunit	Q6SE85	Lactobacillus_prophage	5.1e-77	56.1
WP_019253347.1\|1322825_1323044_-	hypothetical protein	NA	NA	NA	NA
WP_019253348.1\|1323200_1323353_-	hypothetical protein	NA	NA	NA	NA
WP_019253349.1\|1323993_1324461_-	hypothetical protein	NA	NA	NA	NA
WP_019253350.1\|1324540_1324741_-	hypothetical protein	NA	NA	NA	NA
WP_080651472.1\|1324880_1325114_-	RusA family crossover junction endodeoxyribonuclease	A8YQM5	Lactobacillus_phage	1.3e-09	47.1
WP_052317681.1\|1325085_1325307_-	RusA family crossover junction endodeoxyribonuclease	NA	NA	NA	NA
WP_019253353.1\|1325500_1325944_-	hypothetical protein	NA	NA	NA	NA
WP_029507471.1\|1325936_1326260_-	MazG-like family protein	A0A2K9VC24	Lactobacillus_phage	1.1e-19	50.5
WP_019253355.1\|1326463_1326718_-	hypothetical protein	A0A0A1EL18	Lactobacillus_phage	1.7e-15	51.2
WP_019253356.1\|1326717_1326930_-	hypothetical protein	NA	NA	NA	NA
WP_019253357.1\|1326901_1327069_-	hypothetical protein	NA	NA	NA	NA
WP_019253358.1\|1327068_1327650_-	HNH endonuclease	E5DV63	Deep-sea_thermophilic_phage	7.4e-30	53.6
WP_019253359.1\|1327636_1327873_-	hypothetical protein	NA	NA	NA	NA
WP_019253360.1\|1327859_1328072_-	hypothetical protein	NA	NA	NA	NA
WP_019253361.1\|1328084_1328339_-	hypothetical protein	NA	NA	NA	NA
WP_019253362.1\|1328331_1328799_-	hypothetical protein	NA	NA	NA	NA
WP_019253363.1\|1328798_1329260_-	hypothetical protein	NA	NA	NA	NA
WP_019253364.1\|1329259_1329532_-	hypothetical protein	NA	NA	NA	NA
WP_019253365.1\|1329521_1329695_-	hypothetical protein	NA	NA	NA	NA
WP_019253366.1\|1329691_1330495_-	ATP-binding protein	B4XYS7	Lactobacillus_phage	1.5e-52	45.0
WP_019253367.1\|1330513_1331320_-	conserved phage C-terminal domain-containing protein	Q8SDH3	Lactococcus_phage	1.8e-58	48.4
WP_019253368.1\|1331332_1331707_-	single-stranded DNA-binding protein	M1NRI2	Streptococcus_phage	2.1e-41	65.2
WP_019253369.1\|1331699_1332362_-	hypothetical protein	U5U4M2	Lactobacillus_phage	6.4e-54	46.2
WP_020843143.1\|1332373_1333147_-	ERF family protein	D6PSU1	Lactobacillus_phage	3.5e-43	58.9
WP_019253371.1\|1333146_1333734_-	host-nuclease inhibitor Gam family protein	NA	NA	NA	NA
WP_019253372.1\|1333735_1333957_-	hypothetical protein	NA	NA	NA	NA
WP_020843144.1\|1334061_1334217_-	hypothetical protein	NA	NA	NA	NA
WP_019253374.1\|1334206_1334389_-	hypothetical protein	NA	NA	NA	NA
WP_019253375.1\|1334366_1334615_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_019253376.1\|1334629_1334836_-	hypothetical protein	NA	NA	NA	NA
1335103:1335118	attL	NA	NA	NA	NA
WP_035166810.1\|1335289_1336063_-	phage antirepressor KilAC domain-containing protein	A0A2H4JCR9	uncultured_Caudovirales_phage	2.6e-75	55.0
WP_019253379.1\|1336104_1336308_-	helix-turn-helix transcriptional regulator	Q6SEA0	Lactobacillus_prophage	2.0e-14	60.6
WP_019253380.1\|1336481_1336916_+	helix-turn-helix transcriptional regulator	A0A2P1JU09	Anoxybacillus_phage	1.2e-19	40.8
WP_019253381.1\|1336928_1337372_+	ImmA/IrrE family metallo-endopeptidase	A0A2P1JU12	Anoxybacillus_phage	6.1e-08	31.8
WP_019253382.1\|1337428_1338046_+	hypothetical protein	NA	NA	NA	NA
WP_019251651.1\|1338127_1338445_+	hypothetical protein	NA	NA	NA	NA
WP_020843145.1\|1338447_1339578_+\|integrase	site-specific integrase	A0A1S5SA77	Streptococcus_phage	8.7e-51	35.2
1345083:1345098	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1623501 : 1633084

Paenibacillus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020843277.1\|1623501_1625358_-	heavy metal translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.8e-77	30.9
WP_020843278.1\|1625494_1625920_-	hypothetical protein	NA	NA	NA	NA
WP_003665093.1\|1626075_1626789_+	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	1.9e-27	35.2
WP_172395775.1\|1626713_1627637_+\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	4.1e-22	32.1
WP_020843280.1\|1627997_1629380_-	group II intron reverse transcriptase/maturase	A0A0C5K882	ANMV-1_virus	1.1e-18	26.4
WP_019253112.1\|1629867_1630362_-	thiol peroxidase	NA	NA	NA	NA
WP_029507446.1\|1630597_1631974_-	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	3.1e-135	53.5
WP_019253114.1\|1632070_1633084_-	diacylglycerol kinase	A0A1V0SBJ0	Catovirus	1.0e-18	27.0

DBSCAN-SWA_4

1763620 : 1852392

Paenibacillus_phage(28.57%)

protease,integrase,transposase

attL 1757328:1757344|attR 1850173:1850189

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1757328:1757344	attL	NA	NA	NA	NA
WP_019254178.1\|1763620_1764589_+\|transposase	IS30 family transposase	NA	NA	NA	NA
WP_019253671.1\|1764717_1765263_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_003664702.1\|1765280_1765949_-	TrkA family potassium uptake protein	NA	NA	NA	NA
WP_019253672.1\|1765941_1767285_-	Trk family potassium uptake protein	NA	NA	NA	NA
WP_020843302.1\|1767439_1769212_+	oleate hydratase	NA	NA	NA	NA
WP_020843303.1\|1769289_1770051_+	NADPH-dependent oxidoreductase	NA	NA	NA	NA
WP_020843304.1\|1770047_1771187_-	beta-glucanase	NA	NA	NA	NA
WP_020843305.1\|1771201_1772509_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_020843306.1\|1772651_1773515_-	efflux RND transporter permease subunit	NA	NA	NA	NA
WP_042229411.1\|1774699_1775404_-	phosphate signaling complex protein PhoU	NA	NA	NA	NA
WP_003664719.1\|1775414_1776170_-	phosphate ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.5e-14	28.9
WP_019253675.1\|1776180_1777062_-	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_020843308.1\|1777061_1777961_-	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_042229414.1\|1777984_1778857_-	phosphate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_019253677.1\|1778982_1779693_+	response regulator transcription factor	NA	NA	NA	NA
WP_019251596.1\|1779848_1780574_-	ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	6.0e-13	26.0
WP_003664730.1\|1780570_1781419_-	cobalt transporter	NA	NA	NA	NA
WP_019253679.1\|1781387_1782401_-	cobalt transporter CbiM	NA	NA	NA	NA
WP_019253680.1\|1782519_1783374_-	urease accessory protein UreD	NA	NA	NA	NA
WP_019253681.1\|1783363_1783990_-	urease accessory protein UreG	NA	NA	NA	NA
WP_003664736.1\|1784016_1784727_-	urease accessory protein UreF	NA	NA	NA	NA
WP_003664737.1\|1784740_1785190_-	urease accessory protein UreE	NA	NA	NA	NA
WP_019253682.1\|1785273_1786995_-	urease subunit alpha	NA	NA	NA	NA
WP_003664739.1\|1787010_1787388_-	urease subunit beta	NA	NA	NA	NA
WP_003664740.1\|1787418_1787721_-	urease subunit gamma	NA	NA	NA	NA
WP_019253683.1\|1787751_1788270_-	AmiS/UreI family transporter	NA	NA	NA	NA
WP_019253684.1\|1788310_1789519_-	ammonium transporter	NA	NA	NA	NA
WP_042229419.1\|1789783_1790179_-	hypothetical protein	NA	NA	NA	NA
WP_019253686.1\|1790342_1791356_-	hypothetical protein	NA	NA	NA	NA
WP_003671533.1\|1791470_1792001_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_020843311.1\|1792046_1793651_-\|transposase	IS1182 family transposase	A0A146ICT8	Staphylococcus_phage	5.3e-94	41.4
WP_019253688.1\|1793817_1794873_-	hypothetical protein	NA	NA	NA	NA
WP_003664757.1\|1795074_1795632_-	elongation factor P	NA	NA	NA	NA
WP_019253689.1\|1795890_1797072_-	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_020842970.1\|1797264_1798647_-	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	6.1e-30	27.0
WP_042229582.1\|1799267_1805618_-	YSIRK signal domain/LPXTG anchor domain surface protein	NA	NA	NA	NA
WP_020843313.1\|1806128_1821035_-	YSIRK signal domain/LPXTG anchor domain surface protein	NA	NA	NA	NA
WP_020843314.1\|1821485_1835078_-	BspA family leucine-rich repeat surface protein	NA	NA	NA	NA
WP_080651467.1\|1835525_1836389_-	MetQ/NlpA family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_020843316.1\|1836504_1836981_-	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_020843317.1\|1837368_1838055_-\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_019253697.1\|1838078_1838693_-	sugar permease	NA	NA	NA	NA
WP_020843318.1\|1838815_1839871_-	zinc-dependent alcohol dehydrogenase family protein	K7Z7U2	Megavirus	1.2e-06	22.5
WP_019253699.1\|1840297_1840876_-	DUF4767 domain-containing protein	NA	NA	NA	NA
WP_003665093.1\|1842067_1842781_+	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	1.9e-27	35.2
WP_172395775.1\|1842705_1843629_+\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	4.1e-22	32.1
WP_019253704.1\|1843800_1844961_-	MFS transporter	NA	NA	NA	NA
WP_020843320.1\|1845343_1845922_+	TIGR01440 family protein	NA	NA	NA	NA
WP_020843321.1\|1846090_1846963_-	RNA methyltransferase	NA	NA	NA	NA
WP_020843322.1\|1847372_1847639_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_020843323.1\|1847814_1850322_-	BREX-1 system phosphatase PglZ type A	NA	NA	NA	NA
1850173:1850189	attR	NA	NA	NA	NA
WP_020843324.1\|1850323_1850728_-	type II toxin-antitoxin system death-on-curing family toxin	NA	NA	NA	NA
WP_003671431.1\|1850731_1851019_-	hypothetical protein	NA	NA	NA	NA
WP_020843326.1\|1851423_1852392_+\|transposase	IS30 family transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage