CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021714	Alteromonas mediterranea UM4b, complete sequence	3 crisprs	PD-DExK,cas3,DEDDh,WYL,csa3,Cas9_archaeal,DinG,PrimPol,RT	2	1	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_021714_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021714_1

625794-625945

Orphan

Consensus_repeat	Method
GAGGCTAGCATGAACAAACATAGCATGATTTTTATCGGATTGGATACGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021714_1

>merge|NC_021714|1|625794-625945|CRISPRCasFinder
GAGGCTAGCATGAACAAACATAGCATGATTTTTATCGGATTGGATACGCACAAGGAGTTTCACGAGGTTGCCTRTTGTGAAGAGCAGCGTGGAGCGACACCAGAGGCTAGCATGAACAAACATAGCATGATTTTTATCGGGTTGGATACGCA

>NC_021714|1|1|625794-625945|CRISPRCasFinder
GAGGCTAGCATGAACAAACATAGCATGATTTTTATCGGATTGGATACGCA	CAAGGAGTTTCACGAGGTTGCCTRTTGTGAAGAGCAGCGTGGAGCGACACCA
GAGGCTAGCATGAACAAACATAGCATGATTTTTATCGGGTTGGATACGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_021714.1\|WP_012517121.1\|625129_625393_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|224937
NC_021714.1\|WP_020744976.1\|632556_632862_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_012517114.1\|622647_622911_-\|BrnT-family-toxin	unknown	unknown	gnl\|CDD\|367913
NC_021714.1\|WP_020744880.1\|631881_632313_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_015066143.1\|622412_622658_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372110
NC_021714.1\|WP_012517116.1\|623365_623644_-\|plasmid-maintenance-system-killer-protein	unknown	unknown	gnl\|CDD\|282822
NC_021714.1\|WP_023559698.1\|628025_628631_-\|AbiV-family-abortive-infection-protein	unknown	unknown	gnl\|CDD\|275291
NC_021714.1\|WP_020744878.1\|630644_631010_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_012517119.1\|624435_624732_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|368240
NC_021714.1\|WP_012518317.1\|627662_627869_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_015066144.1\|624030_624324_+\|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family	unknown	unknown	gnl\|CDD\|224937
NC_021714.1\|WP_148289229.1\|628821_629151_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_020744877.1\|629708_630098_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_012517120.1\|624735_624954_-\|addiction-module-protein	unknown	unknown	gnl\|CDD\|378247
NC_021714.1\|WP_012517161.1\|631128_631575_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_012517122.1\|625379_625613_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_012517117.1\|623792_624041_+\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl\|CDD\|225072
NC_021714.1\|WP_012517115.1\|623072_623366_-\|HigA-family-addiction-module-antidote-protein	unknown	unknown	gnl\|CDD\|274228
NC_021714.1\|WP_015066158.1\|633000_633375_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_020744876.1\|629263_629602_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021714.1\|WP_023559698.1\|628025_628631_-\|AbiV-family-abortive-infection-protein	gnl\|CDD\|275291	TIGR04498, hypothetical_protein_X730_20110, abortive infection protein, AbiV family. This family includes AbiV (abortive infection system V) from Lactococcus lactis, a phage resistance protein that causes certain phage infections to fail to lead to successful phage replication. Abortive infection mechanisms differ greatly. AbiV interacts directly with the protein SaV in phage p2 and blocks translation of phage proteins.	1.40588e-46
NC_021714.1\|WP_012517121.1\|625129_625393_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	2.1316e-13
NC_021714.1\|WP_015066144.1\|624030_624324_+\|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family	gnl\|CDD\|224937	COG2026, RelE, Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning].	2.4714e-18
NC_021714.1\|WP_015066143.1\|622412_622658_-\|hypothetical-protein	gnl\|CDD\|372110	pfam12441, CopG_antitoxin, CopG antitoxin of type II toxin-antitoxin system. CopG antitoxin is a member of a type II toxin-antitoxin system family found in bacteria and archaea. Most antitoxins encoded by the relBE and parDE loci belong to the MetJ/Arc/CopG family of dimeric proteins which bind DNA through N-terminal ribbon-helix-helix (RHH) motifs. The toxin for CopG proteins falls into the family BrnT_toxin, pfam04365.	0.00109921
NC_021714.1\|WP_012517116.1\|623365_623644_-\|plasmid-maintenance-system-killer-protein	gnl\|CDD\|282822	pfam05015, HigB-like_toxin, RelE-like toxin of type II toxin-antitoxin system HigB. This family carries several different examples of type II bacterial toxins of toxin-antitoxin systems including many HigB-like ones. The fold is referred to as the RelE/YoeB/Txe/Yeeu fold suggesting all examples of these are present in this family. Several plasmids with proteic killer gene-systems have been reported. All of them encode a stable toxin and an unstable antidote. Upon loss of the plasmid, the less stable inhibitor is inactivated more rapidly than the toxin, allowing the toxin to be activated. The activation of these systems results in cell filamentation and cessation of viable cell production. It has been verified that both the stable killer and the unstable inhibitor of the systems are short polypeptides. This family corresponds to the toxin.	1.27632e-26
NC_021714.1\|WP_012517120.1\|624735_624954_-\|addiction-module-protein	gnl\|CDD\|378247	pfam09720, Unstab_antitox, Putative addiction module component. This entry defines several short bacterial proteins, typically about 75 amino acids long, which are always found as part of a pair (at least) of small genes. The other protein in the pair always belongs to a family of plasmid stabilisation proteins (IPR007712). It is likely that this protein and its partner comprise some form of addiction module - a pair of genes consisting of a stable toxin and an unstable antitoxin which mediate programmed cell death - although these gene-pairs are usually found on the bacterial main chromosome.	2.05064e-08
NC_021714.1\|WP_012517115.1\|623072_623366_-\|HigA-family-addiction-module-antidote-protein	gnl\|CDD\|274228	TIGR02607, Virulence-associated_protein_I, addiction module antidote protein, HigA family. Members of this family form a distinct clade within the larger family HTH_3 of helix-turn-helix proteins, described by pfam01381. Members of this clade are strictly bacterial and nearly always shorter than 110 amino acids. This family includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is uncoded by the upstream member of the gene pair. [Regulatory functions, DNA interactions, Regulatory functions, Protein interactions, Mobile and extrachromosomal element functions, Other].	7.1718e-37
NC_021714.1\|WP_012517114.1\|622647_622911_-\|BrnT-family-toxin	gnl\|CDD\|367913	pfam04365, BrnT_toxin, Ribonuclease toxin, BrnT, of type II toxin-antitoxin system. BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralizes this toxin is pfam14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA.	9.01688e-30
NC_021714.1\|WP_012517119.1\|624435_624732_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	1.10053e-05
NC_021714.1\|WP_012517117.1\|623792_624041_+\|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl\|CDD\|225072	COG2161, StbD, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning].	1.46908e-12

>NC_021714.1|WP_012517122.1|625379_625613_-|hypothetical-protein
MSTLSKRSTVYFEPAIHNALKLRAASSDTSISELIDEAVRLLMKEDQEDLAAVRQRAKEPEISYEDLLNTLEADGKI
>NC_021714.1|WP_012517121.1|625129_625393_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MEKYSVTFKKSVAKDFRAIPKSDVKKILAKIDLLAENPRRDGAIKLSGLDLYRIRQGLYRIIYEIRENELVVQVIKVGHRSDVYKRT
>NC_021714.1|WP_012517120.1|624735_624954_-|addiction-module-protein
MSDALKVMLANIEQLSTKEKALAAHCLLTAMDTKIDSDVESEWVKLAESRSAELESGAVKSISWEEIEKDLN
>NC_021714.1|WP_012517119.1|624435_624732_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MLPVSFHPEVKREIKESFDWYQEQSLGLGHEFTQELKEAIDSVSSLPSAWTKIGQTHRRFVLSRFPYSIIYKIIENREISVVAIMHNHRKPGYWHERG
>NC_021714.1|WP_015066144.1|624030_624324_+|type-II-toxin-antitoxin-system-mRNA-interferase-toxin,-RelE/StbE-family
MTYKLEFKSSALKEWNKLGSTLQQQLKKKLAERLKTPHVAPERVLGADNVYKIKLRQSGYRLVYQVLDDVVVVTVLAVGKRERNEAYKKALKRLDVE
>NC_021714.1|WP_012517117.1|623792_624041_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MATRILADVAASITELKANPMKVASSAYGDPVAILNRNEPAFYCVPAEIYEKMMDRLEDLELLQLVKERQGEESVSVNLDDL
>NC_021714.1|WP_012517116.1|623365_623644_-|plasmid-maintenance-system-killer-protein
MIKSFKHKGLKLFFEKGKTSGIQTKHAKKLRMQLAAIHTAQDIDDINLPGFSLHQLKGERSNIWSISVNGNWRVTFEFTDGNAYILNYEDYH
>NC_021714.1|WP_012517115.1|623072_623366_-|HigA-family-addiction-module-antidote-protein
MNMHNPPHPGEFIESIYMEPHGISCRTLATHLGVAASTLNRVVKGKSAVTPEMALRLSKVLGRSPESWLSMQDNYELWQAKQNINLDNVQPIDLHTA
>NC_021714.1|WP_012517114.1|622647_622911_-|BrnT-family-toxin
MQNFEFDQSKSDSNFTKHGIDFVEAQKLWNDPMLLEIPAKTEDEPRYIIIGLIGGKHWTAVITHRNKNIRIISVRRARKSEVAIYES
>NC_021714.1|WP_015066143.1|622412_622658_-|hypothetical-protein
MKAKNFEENFESGDEILQHLDLSKAKRPMQKQKRINVDIPEWMVDSLDREAGRVGVTRQSIIKVWLAERLEQSQSLERASS
>NC_021714.1|WP_012518317.1|627662_627869_-|hypothetical-protein
MAVYSQEATELMSKYREADEAESVAIKALDEYMKAGGGELIRDLSEKMESAHAKKLSIYNEMQKYRLD
>NC_021714.1|WP_023559698.1|628025_628631_-|AbiV-family-abortive-infection-protein
MNAANDNARRLAEDAEVLFNLNRFPSALSLAILSIEESGKISILRELALAQNGNQVKESWKAYRSHTKKNVMWLFPHLASSGANKLEEFKSLFWEKAEHPLLLDNLKQIGFYTDCLGKAHWSIPVEVVDKENTENILNIAKLMCKETTYSTKEIELWVKHIKPVWRGPMDAMKIALNNWFNEMVKEGIISEGQYSFKDFVD
>NC_021714.1|WP_148289229.1|628821_629151_-|hypothetical-protein
MPRMNRLQALNEIINFGPNLKLAEIRIHELPFDTDEELITINRHHVEKVLNMFINGEISDETVEQWANFIEGREDLNYDVFGNLIHILANPVLEGKLSISKARKFLDAI
>NC_021714.1|WP_020744876.1|629263_629602_-|hypothetical-protein
MKKFLVFLVPIIFLLSYCQKNIGGITASEIDKELSSALKVGDSLEKIEISLNKLNIGYHYDSDLGLFDASPKDKNYNCVRYFLYDCAVLIKVYTDDTQRYKAHNVEVIYSGI
>NC_021714.1|WP_020744877.1|629708_630098_-|hypothetical-protein
MRAIFWFITAIIIVLSFVCSGHNSENESDGIFLVGLGSWAPVVLAFVFHNLEKKAKLLLYATACSFLAVSAFALFYLGLLALHVLETGSLGPSGMILAFFPFAYIGLALAGAALGLCMYLTERMIKKYA
>NC_021714.1|WP_020744878.1|630644_631010_-|hypothetical-protein
MYLGDWDKAIVRSLLTSSLLLPAIFLIGADNLQSSEIPGLIATFSLYIGVFLLVSIAGWLIIGFPVHWLACKYKKTNYLFYMVLPVTFSLVSGTTNGPWILGVIASVQTLIFRYVVFKNKT
>NC_021714.1|WP_012517161.1|631128_631575_-|hypothetical-protein
MNISFDDYMDSIKANRKSMPPELFSFASNEDHYELNHPQSLHDSWVSSLCIEELRNNTRPFECSLRVTLKLLGQQHDRTLVLIYSDVVAYEFLSSENSFNPNDTFHGDILDHRISIAGDAYNHIIEMRSGSIFKVVFKGFSFEEQSST
>NC_021714.1|WP_020744880.1|631881_632313_-|hypothetical-protein
MADDTKIARVLRISNLNILAGIVALIGILGFVLVYVGWKARNCFFISAEFDANKQINRTKNSWLLLVPRYFSHQFLACYLGVIRHGVFSFCNLSRYIPESALIQLFSHLAFRRNHQTHFATGSFAQEKARTQQNGLILVALKN
>NC_021714.1|WP_020744976.1|632556_632862_-|hypothetical-protein
MDIFQRLKKLVVFLYITAKWIGLIVWWIALASMVWAEGWSILLVSDRAGNPVIGVIFVDKKENQAISQSVSIEVKESSMDTAVNNAVAPVNIHHSSFGSNS
>NC_021714.1|WP_015066158.1|633000_633375_-|hypothetical-protein
MRKGFNKQTLIRWKVYIDRSKMYVGYIQFLLIIFVFINSLDNNPVSQFVLEKPLIAVPVILVLFVLCSLVLGYMDSKLGFREEEIRNHARSNPVLRQIQISLDEVNLKLDKLEKSEGENRKSGI

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Crispr_ID: NC_021714_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021714_2

1851833-1851928

Orphan

Consensus_repeat	Method
CTGATAGCTGTCGGTTTTTGTATTGCAACGATTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021714_2

>merge|NC_021714|2|1851833-1851928|CRISPRCasFinder
CTGATAGCTGTCGGTTTTTGTATTGCAACGATTCGGTCAATAAGCTTATTTTCAAGACTCTACTGATAGCTGTCGGTTTTTGTATTGCAACGATTC

>NC_021714|2|2|1851833-1851928|CRISPRCasFinder
CTGATAGCTGTCGGTTTTTGTATTGCAACGATTC	GGTCAATAAGCTTATTTTCAAGACTCTA
CTGATAGCTGTCGGTTTTTGTATTGCAACGATTC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021714.1\|WP_015066905.1\|1854639_1855251_+\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_015066907.1\|1856414_1857626_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_021714.1\|WP_015066897.1\|1844259_1846200_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|379843
NC_021714.1\|WP_015066898.1\|1846199_1846826_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226198
NC_021714.1\|WP_015066893.1\|1840907_1841663_+\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_015066909.1\|1858813_1859533_-\|WecB/TagA/CpsF-family-glycosyltransferase	unknown	unknown	gnl\|CDD\|119439
NC_021714.1\|WP_020745009.1\|1848543_1849446_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368570
NC_021714.1\|WP_015066904.1\|1853492_1854497_+\|polysaccharide-pyruvyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|377253
NC_021714.1\|WP_015066901.1\|1849604_1850636_+\|acyltransferase-family-protein	unknown	unknown	unknown
NC_021714.1\|WP_015066896.1\|1843573_1844143_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_015066911.1\|1860657_1863093_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_015066892.1\|1840186_1840918_+\|capsular-polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|226870
NC_021714.1\|WP_148289235.1\|1859737_1860217_-\|sulfotransferase	unknown	unknown	unknown
NC_021714.1\|WP_020745012.1\|1855572_1856418_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|182197
NC_021714.1\|WP_041703162.1\|1842119_1843526_-\|O-antigen-ligase-family-protein	unknown	unknown	gnl\|CDD\|377422
NC_021714.1\|WP_148289236.1\|1863238_1863691_-\|sulfotransferase	unknown	unknown	unknown
NC_021714.1\|WP_015066899.1\|1847178_1848411_+\|O-antigen-ligase-family-protein	unknown	unknown	gnl\|CDD\|377422
NC_021714.1\|WP_015066894.1\|1841675_1842086_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_015066908.1\|1857626_1858802_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133060
NC_021714.1\|WP_015066903.1\|1852411_1853380_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133039

Protein	Function_ID	Function_description	E-value
NC_021714.1\|WP_041703162.1\|1842119_1843526_-\|O-antigen-ligase-family-protein	gnl\|CDD\|377422	pfam04932, Wzy_C, O-Antigen ligase. This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.	6.74655e-09
NC_021714.1\|WP_015066897.1\|1844259_1846200_-\|EAL-domain-containing-protein	gnl\|CDD\|379843	pfam16448, LapD_MoxY_N, LapD/MoxY periplasmic domain. This domain is the N-terminal periplasmic domain of the LapD and MoxY receptor proteins.	2.8278e-50
NC_021714.1\|WP_015066898.1\|1846199_1846826_-\|hypothetical-protein	gnl\|CDD\|226198	COG3672, COG3672, Predicted transglutaminase-like cysteine proteinase [General function prediction only].	3.24038e-35
NC_021714.1\|WP_020745009.1\|1848543_1849446_+\|hypothetical-protein	gnl\|CDD\|368570	pfam05704, Caps_synth, Capsular polysaccharide synthesis protein. This family consists of several capsular polysaccharide proteins. Capsular polysaccharide (CPS) is a major virulence factor in Streptococcus pneumoniae.	4.81543e-68
NC_021714.1\|WP_015066904.1\|1853492_1854497_+\|polysaccharide-pyruvyl-transferase-family-protein	gnl\|CDD\|377253	pfam04230, PS_pyruv_trans, Polysaccharide pyruvyl transferase. Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.	1.56365e-16
NC_021714.1\|WP_015066903.1\|1852411_1853380_+\|glycosyltransferase	gnl\|CDD\|133039	cd04196, GT_2_like_d, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	4.31591e-34
NC_021714.1\|WP_015066892.1\|1840186_1840918_+\|capsular-polysaccharide-biosynthesis-protein	gnl\|CDD\|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.33863e-55
NC_021714.1\|WP_020745012.1\|1855572_1856418_+\|glycosyltransferase	gnl\|CDD\|182197	PRK10018, PRK10018, colanic acid biosynthesis glycosyltransferase WcaA.	1.21267e-30
NC_021714.1\|WP_015066899.1\|1847178_1848411_+\|O-antigen-ligase-family-protein	gnl\|CDD\|377422	pfam04932, Wzy_C, O-Antigen ligase. This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.	2.7435e-13
NC_021714.1\|WP_015066909.1\|1858813_1859533_-\|WecB/TagA/CpsF-family-glycosyltransferase	gnl\|CDD\|119439	cd06533, Glyco_transf_WecG_TagA, The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common antigen (eca) synthesis. B. subtilis TagA plays a key role in the Wall Teichoic Acid (WTA) biosynthetic pathway, catalyzing the transfer of N-acetylmannosamine to the C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid to make ManNAc-beta-(1,4)-GlcNAc-pp-undecaprenyl. This is the first committed step in this pathway. Also included in this group is Xanthomonas campestris pv. campestris GumM, a glycosyltransferase participating in the biosynthesis of the exopolysaccharide xanthan.	1.19281e-44
NC_021714.1\|WP_015066908.1\|1857626_1858802_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133060	cd06438, EpsO_like, EpsO protein participates in the methanolan synthesis. The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.	1.42164e-66
NC_021714.1\|WP_015066907.1\|1856414_1857626_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.56484e-50

>NC_021714.1|WP_015066901.1|1849604_1850636_+|acyltransferase-family-protein
MLSNETSIQIQYCRILCIYFMIVVHIPPWLEHAHIPSFFEPIKIFYYDIFGRSSVTALSCISGFLIYFTIIKRDWLNVIVSRCKSIVVPMAFWNSVTIFFALIILYTLGKPLPASNLVIESSYFEVVVNGIFSLNNKPAAGSLAFLRDLFVCVLLSFPLAALIKRFSWLVLVAAVIVHLTISFQPLVFRGTILVAFITGLTVAYSIGHLKISFFLRLLYVLGLIVVFLIEFSNASQFYLYNEFKRLTLSLFLIDLSYVLTKFRKFKWLLWLAPSTFLVYLTHELVFMMLWGGWVLVFGNEITPQYLAFFFFIPVLWFLLIAITLPLISYFPAFLQVLIKGKVS
>NC_021714.1|WP_020745009.1|1848543_1849446_+|hypothetical-protein
MFFWQFISNRVSKNSNAQSALEVKKHTAIKNKLISSLDFDFDSYSNSQQNEIVERPAIWYFWWDGKDNLPDVCLDCLKSIEMNCCERKVIFVDKNNYRDFVKIHPVIEKKFKEGIIPIQQFSDVLRVELLKTYGGLWLDATIFITSDLENELNSRFFTLKHGTQTRFVSNGRWSISCIGAEKAHPLFMFLSDAFKRYYSKYDSLVDYFLMDYLVDIAYENIPRVSDDVDSIVKNNPDVYFLQNNFEQKFDPVKFKKIALETKIFKLNWRVKQNSTSANEDSYAYYLSALITQNKDGFSSN
>NC_021714.1|WP_015066899.1|1847178_1848411_+|O-antigen-ligase-family-protein
MIIRKSPLYIFSPVIYLLLLTRASLDPILKMTDFGGISFGALLNLAVIVFFFGGLLQNRGSIPASVIKLWAGFLVVGLISIVISPTPLTSFRSFVSVLTYFAIFSLAYTFVRSKEDLESIIKLIIYSSSIPFAVSIVQFVFPETSTTRHGFRLHGTFSHPNIYAFYLVLIAAVSFYSIKSNTVFFSKRFIRLCIALLPLSAICVIATQTRSAWVAFFAIFFIYGVLYERKYVVLMCCIGVLALFLPFVQDRIADLASDSQMTDSGGEKLNSYAWRKVVWLSSWEFIQNKIFFGHGYNTFAYYFLDFFTMEESHGFDAHNAYVQIAFDMGFVGLFFYLVLLVGILLKHLKSFAKDPKGNSVLLALIASYMVVCYSDNILFYLSYCWYLWLLLGATCAILEKRVKKKFNSPY
>NC_021714.1|WP_015066898.1|1846199_1846826_-|hypothetical-protein
MLAPVLVAQQSTVFTEQVYLRISAAYGPEASEDVAKWRQLVTELQSEDLDEKLYEINRFFNRLDFVDDLVHWQQKDYWATPIEFISTGAGDCEDYTIAKYFSLIELGVPEQQLRLMYVTALELRQPHMVLAYYETPTSIPLVLDNINRRILPANKRRDLSPIYSFNGNGLWAAKAMGTGRKLRGSGPMKMWDDMVERLDRVMYGDKKE
>NC_021714.1|WP_015066897.1|1844259_1846200_-|EAL-domain-containing-protein
MRLSTQLSTSLLVFLILVFAGSFIINVKLTREYVNEQLATHAQDTATSLGLSITPYLSEDNGIAVAETMVNAIFDRGFYQYITITDMEGNLLIERRNPNTIDTVPDWFTNIVEVTPPVEKTELNNGWTMAGKLAVQSHPGLANETLWESVKQSAFMFFAAFVFAYIALLFIITAITKPLRIVVNKIEDIQNQKFSHINYKPFTKELSFITQAVNRLSSSVEVMFKELTQKAEQFRIQAFEDSLTGVQNRNAFTRHMNALLSKTATSDEGYVILIRLAQLNAINMTLGAQDGDKYVIGVAEELKKFSSSIQETSFLFRVSGADFVLVTEAMTKKECEAHLQVLNTTLSHYNPLKDGSKAVWIGAAQFNDQQSFSEIMENADSALMAATKQPNGWQFASELSHIHSNTAWKERLNQILQQQYADILIQPVMNVDKNTPAYFEAFARFKDKDTGNPIPMSQLIPASERLNLIPEVDKLVVSLVLNKLAKDKCNVAINIANASLANASFRQWLLGVLNQNEALCTYLIFELEDSALIHHKDDAILFCKSLVNLGCKITIEHFGDNLASLAGLRAIQPHFVKISGKLTKDIHADQDSQLFVSSLLSIARGLSISIIAELVENEAESVALTRLDVVYQQGFYFAKPSLWQYQ
>NC_021714.1|WP_015066896.1|1843573_1844143_-|hypothetical-protein
MRSNVFLSVLLGALIAVSTVSFAQEGSVPGLQVRNLLVTEIEEGAAVEQAAGEVSQTVLDEALFFDASAMAYLGENQSAFEALVGLLNDNATGFELAIAGFTELPEQAAQVVTITILMFPENANEIYNIALQMQVISEEDALLAVINAGVDPSTLTATAAGAAGNTFSPLGVGTGAAGAGGGDTTVSAN
>NC_021714.1|WP_041703162.1|1842119_1843526_-|O-antigen-ligase-family-protein
MFNSQKTEKFLFGFLLFTLFWLPLSLGANRPWAWALMQMSFFFIGGVLLLTHKTLLSQLCAKYKLFVIVWLTFLTWQLMNIVPLPFALVEAIRPQRVQFLLNGYIENIESIRSQWLALSFDVGQSDVTFFKSLAYCFLFFISLTLISSAKRLKYTLIVISGAGIFQAVYGSLEVLSGINYSLVFKLPVSHIATGSFVYKNHYANFLLLCLSAAIGYMIASLRVRSGSSPRERLRRIVRFWLSNKVLFRIGIIIMVIALVMSRSRMGNSAFFIAMTTTATLGLIYFKPRQKSYVALFISMLVIDILIVSSLFGLKQVQQRIEQTNLTQESRDEVVTDALPLLSQYGAIGTGGGTFYTVYPQVQSETIQHFYDHAHNEYLQFAIEFGAVGAALLAALVLLCAKNAMSAIRHRRHPLPRGTAFAAVMAVIGMALHSTVDFPLQAPANTAIFIVLLALGALSRNIPMGRQNK
>NC_021714.1|WP_015066894.1|1841675_1842086_-|hypothetical-protein
MVLKIKRPIKEEPNVQHMLERMPKDVANSFTDDQLFHLNTALAGRRWGSHKVDVRGTIGLLRSRYYFVLLAGRDKRDLSRTESRIGKLVMAAVVALFLCVSLLVGLVLLYILKSWLGINLFEGFSLGLWDWLKGNT
>NC_021714.1|WP_015066893.1|1840907_1841663_+|hypothetical-protein
MLFENLLVRNTSGFSWSRTLTYFIALIAFLSFLGSAKQFLVSNTYYSVKNSLDGWSSAPSSVSVKEVEIALTKIEEVIDKTPNNALYYQLQGQLYEWLHFSFANDSEVLTSAINQTSALQSAALSYKESLKLRPNWSGGWIGLASVKWKLGELDSQFYQYLNNAVSIGPQDAIVHRFIAEFGLTMYVNRSVHYAKIFKRLRHHLDLGTKNPLSRKFILEFISENNLNEPVCRWLGSSAYAASTGLLNCKIS
>NC_021714.1|WP_015066892.1|1840186_1840918_+|capsular-polysaccharide-biosynthesis-protein
MIDLHSHILPGIDDGARSLDIALEMAEQAVSCGISHMVCTPHIHMGYFDNSFSSIAEAFYSFNEHVKRESIPLSLSFAAEVRVNELIPIWHKKGELPFLGKYDGKNVLLLEMPHSHIPQGLDVLIKWLLRNNIQPLIAHPERNRELIAENDKFNWLQRQGCLFQATAGAFVGRFGERVEEFAFRLLEKGAFHVVASDTHDLIRRPNDMQAALEVVSKYNSEYAEALFIKTPGRIIALDQNNAV
>NC_021714.1|WP_015066903.1|1852411_1853380_+|glycosyltransferase
MSVSVSAIIPVYNGESFLRDAIESILQQTHQVSEIIIIDDGSKDKSFDIAFSISKSSSVPIRVFRQQNSGVSVARNLGLLKSSGDLVAFLDVDDIWKPTKIEKQLALYDELKNHEAFIFTDYYLDDENDTCRALAGYTDYNVCTQTNFSKEDFQLAFIRRNFVGTASTVIFNRELAVKIGGFNNRLNHSEDFDFILRYSQHGCVYVITDPLAVKRSHGANLSGDLKLHFWSHYIALKSNIDLSSPFTRFNYRRDVEYEMMLSHDTYLVRFCNQVYEISIKNGLKKYFEAIPKIKTLRGFKVFLKAFIRKLIRTASFGVIKRS
>NC_021714.1|WP_015066904.1|1853492_1854497_+|polysaccharide-pyruvyl-transferase-family-protein
MKNDLIIYGYNCKNLGDDLMFAEIINKTDYKRYFFIGHGEVPNFVNKEIFFIKPGRLMKLRWKLKADFAVIGGSVLMGASPQQKDAIRQKIEWFKWNKITGGRNFIIGANLGPYDDEKEYLELLSALSSVVDKWFVRDKVSFDMLEKVKTRYLKLMPDIVMGFDKERFMEESDSSVAISVTSVGKDNNNLIDAESYAGEIAQLAQSYIDQGKSVKLLSFEDRVDLEPIDKIESLIKQTNGSVNIIKNVGEDIVKAIAQADVVVSTRFHAMVLAALFEKKQIIYAYNNKTTQFAQTYGFETYAVTGSYVGKDPVKTSFEKDVLKFVNTYAKLVQK
>NC_021714.1|WP_015066905.1|1854639_1855251_+|hypothetical-protein
MKKLVLAIFSVLSFTANAAVIELDFSDTFANYGNQFDSGTVSAENGGKTLSMFGNNWVAFEGVYNITADTILQVTFSSSQIGELHGFGFDNDVVFDSVDDYKNGENRYFQFAGTQTFGVQDYNTYSVPNTLETFTVEVGKFLTGTFSQLVFINDQDKSGANAQSSYSISTSDSNFVASVNGPGVLTLMLMSLTLMFASKRNRK
>NC_021714.1|WP_020745012.1|1855572_1856418_+|glycosyltransferase
MLVTVYITTYNRRKLLERAINSVLNQTHSPIELIVADDGSTDGSQEYLTEMHEQGILTAILNTTGKSKGACYGRNRAISMAKGEFISGLDDDDYFEPWRIETFIKKWQEYTVNINVFSALFDSVVEHRKSGPVACYDTGVATYQKLRKGNVVGNQVFTKTSYLKAVGGFDEQMPALQDWDTWLRLSNQYGDILNVNTRSYIQIQNHEGERITGKPADKIRFAFNRLMNKLQPLTRSEESHLLATMYSGYPQIDIRISELFKIFMGGHFRKVAQVVKRTLLK
>NC_021714.1|WP_015066907.1|1856414_1857626_+|glycosyltransferase-family-4-protein
MKILYLINQYPKVSHTFIRREIMSHEENGIEVLRVAMRSDDPNDMSKVDSTEYEKTHYVLKQSKLELLKHVFSAIKENPKSFLKALKVLFKMHSASKQSLLIHLIYLVESCNVAKVCKESDVDHIHAHFGTNPAEVAMYTSIISGVPYSFTVHGPEEFDKPLTLNLNQKIKYASRVIAITNYCKSQLFRWADYEDWQKVGIVHCGLEDKFFNEQTLNSRREGDEYRFLCIGRLCEQKGQLLLLEAFSRFINAGFKAHLTLAGDGEMRVEIESFIKQHKLQRNVTITGWVDSIEIKELLSKSDAMLLPSFAEGLPVAIMEAMATGVPVISTAIAGIPELVVDKVTGFLVFPGSVNSLEDALVAFTKLSQSELDAVRKRAFEAVKKEHNITTEAEKLAVLVGAKE
>NC_021714.1|WP_015066908.1|1857626_1858802_+|glycosyltransferase-family-2-protein
MILLAIIFFIVAFVSAFLSLQLFLGLRNSNSVEVNNSDNTLPCVVLIPAHNEELGIAKTIMSARKEVKEGDLILVVADNCSDSTAAVSRDAGAICIERTNLELVGKGHALQYGIDYLTENDVEFATVVVMDADCLFGEGSLHALLNASQTKNCVAQALYLMRSPNKSNIKLNISEFTWLIKNWVRPLGQKRLGISCHLQGSGMAFPKSVLNQYSLASSSIVEDLELGLHIVKGGEEVTFVPRALVTSEFPENNEGLENQRKRWEHGHLSVVKKMPSTMLQGLKELNFRLFFQALDAAIPPTIMWIILTILTLVVSFIAAIFDGFYWSTVIGLCISVFAFAIVCVWFKYGKKILPPAQLKGMIPFVLGKFSVYRTFVSNREKNWVRTKRDNE
>NC_021714.1|WP_015066909.1|1858813_1859533_-|WecB/TagA/CpsF-family-glycosyltransferase
MKSIASKITPAKTELQAITLTEKELRKDQVSVISFINAHAYTMANSDNKFKNCLLGADLLFRDGIGAKILLKKYGMPVGYNANGTDLIPLILDRFKGKSVCFIGTESPYIEQAASIYKSNGHNVKAFIDGFQSNEKMFEFVEAYQPEILILGMGMPKQEYFSALLQRNYEKPLVVVNGGAIFDFIANRFTRAPSIFRRLNLEWLYRLMNEPIRLFNRYAIGIPKFFWILRKNMKQERLG
>NC_021714.1|WP_148289235.1|1859737_1860217_-|sulfotransferase
MNVKQDNLYNYFLDSKEISVIHLKRSNILKRLISAMLMHQAGVVSTTDNSTENKSFEIDIEQLLAKLKRDYELNEEENAFAAKLSKKQPFYQLSYEDYFSSPESTSKHNSQIFDFLGVESTQVKSKHRKVLSQNLADIITNYDDIERALKTTKFEQYLY
>NC_021714.1|WP_015066911.1|1860657_1863093_-|hypothetical-protein
MKVPSLSIAALYLLTIILVSSLLSSCLSTLTSTAQKTQLGDELLATSSEIINEKDSVLHSYVASFLKEHTQNEFSDAHVTNIVEMLRTGTLASASNGNLNFIPTWKQDDKEEIKTKIETLLILFPKSAKSLSQKASQQELLSSQEFVELIVKANLDPTLVMGVPASSGEPDILRIGWGGSGLFSSVVEFEGEIYASSDVTGVWKFNGSGWDPLVKGLTNYNITGLLVHHNSLLAATKNQLLELRADNTWSPIGLELKTYRNTTLQLYSTSSSGVTCFAALQPSLGCIDKNGNVSKTPLSISKLKGVYFDESDDYLFGFNGKKLYRISKSDGSQTLEYTFPTNILRIENLDASLGALIYTKKGIFELDSFASITVDLKNKSILNVLKDTTSEGNHLIALGSTWNAGLYKLKSSPEGLTIGAKVPISFDTSLPFRKWRKVMTKPLGMPHSVLGKIWFSDYRGIYGYDVRTSKIYEKSKDASNFVGTDIHIDADKLYITSMDNGLVSMPLKTPNKFTQIFPRRGSDWLLAGHTWSVNSNEQGVFATLSPWNLAQDYLLTADKENNFLNVQKIDDATNRSNAEAFWSQSYSRKLVVDEEILVYKDGSIGGLFKLKFTPRQNDNDIQETTSEKIFSTSNNRVYRALLKTDKYIVSYHIDDEQKLYFNDIETKALVKTVNAPAGLWAFNIAYIDGEIYIIGARGNAVVYKYNESENNFVEVLNEPSSSAFLSLNKAPNGLLTIAGAVSWGGSSSGKVLVNKRQSDTWIDMTCLLGNESGVVDTEFSSDGRFIYLLQKVGAITRIKTAFLSTFEGCKN
>NC_021714.1|WP_148289236.1|1863238_1863691_-|sulfotransferase
MNVKQDNLYNYFLDSKEISVIHLKRSNILKRLISAMLMHQAGVVSTTDNSTENKSFEIDIEQLLAKLKRDYELNEEENAFAAKLSKKQPFYQLSYEDYFSSPESTSKHNSQIFDFLGVESTQVKSKHRKVLSQNLADIITNYDDIERANN

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Crispr_ID: NC_021714_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021714_3

2991190-2991321

Orphan

Consensus_repeat	Method
ATGGTGCGGAAGGAGAGACTTGAACTCTCACGCCGTGAAGCACTGGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021714_3

>merge|NC_021714|3|2991190-2991321|CRISPRCasFinder
ATGGTGCGGAAGGAGAGACTTGAACTCTCACGCCGTGAAGCACTGGAAGAATGCTTTGTTAAGCTTTTAATAAAGCTTGAAAATATGGTGCGGAAGGAGAGACTTGAACTCTCACGCCGTGAAGCACTGGAA

>NC_021714|3|3|2991190-2991321|CRISPRCasFinder
ATGGTGCGGAAGGAGAGACTTGAACTCTCACGCCGTGAAGCACTGGAA	GAATGCTTTGTTAAGCTTTTAATAAAGCTTGAAAAT
ATGGTGCGGAAGGAGAGACTTGAACTCTCACGCCGTGAAGCACTGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_021714.1\|WP_012518976.1\|2981435_2981606_+\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_012517557.1\|2992991_2994011_+\|phospholipase-A	unknown	unknown	gnl\|CDD\|376748
NC_021714.1\|WP_012518992.1\|3001519_3002770_+\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_041702787.1\|3000151_3001504_+\|exodeoxyribonuclease-VII-large-subunit	unknown	unknown	gnl\|CDD\|234714
NC_021714.1\|WP_012518982.1\|2988686_2989316_-\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NC_021714.1\|WP_041703397.1\|2994102_2995005_-\|histone-deacetylase	unknown	unknown	gnl\|CDD\|212519
NC_021714.1\|WP_012518989.1\|2996933_2998511_-\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NC_021714.1\|WP_041703389.1\|2978169_2979888_+\|lysophospholipid-acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|153248
NC_021714.1\|WP_012518988.1\|2995124_2996747_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NC_021714.1\|WP_012518981.1\|2987338_2988613_-\|ATP-dependent-protease-ATP-binding-subunit-ClpX	unknown	unknown	gnl\|CDD\|235422
NC_021714.1\|WP_012518978.1\|2983998_2984271_-\|DNA-binding-protein-HU-beta	unknown	unknown	gnl\|CDD\|259853
NC_021714.1\|WP_012518977.1\|2981795_2983688_-\|peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|182731
NC_021714.1\|WP_012517547.1\|3003477_3004923_-\|ribosome-biogenesis-GTPase-Der	unknown	unknown	gnl\|CDD\|234628
NC_021714.1\|WP_012518975.1\|2980017_2981190_-\|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl\|CDD\|349886
NC_021714.1\|WP_012518990.1\|2998581_3000051_-\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NC_021714.1\|WP_012518983.1\|2989414_2990719_-\|trigger-factor	unknown	unknown	gnl\|CDD\|234956
NC_021714.1\|WP_012518980.1\|2984592_2986944_-\|endopeptidase-La	unknown	unknown	gnl\|CDD\|223542
NC_021714.1\|WP_012518993.1\|3002824_3002998_-\|hypothetical-protein	unknown	unknown	unknown
NC_021714.1\|WP_012518986.1\|2992113_2992956_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293801
NC_021714.1\|WP_012518582.1\|2977202_2978000_+\|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl\|CDD\|277343

Protein	Function_ID	Function_description	E-value
NC_021714.1\|WP_012517557.1\|2992991_2994011_+\|phospholipase-A	gnl\|CDD\|376748	pfam02253, PLA1, Phospholipase A1. Phospholipase A1 is a bacterial outer membrane bound acyl hydrolase with a broad substrate specificity EC:3.1.1.32. It has been proposed that Ser164 is the active site for Escherichia coli phospholipase A1.	9.54325e-108
NC_021714.1\|WP_012517547.1\|3003477_3004923_-\|ribosome-biogenesis-GTPase-Der	gnl\|CDD\|234628	PRK00093, PRK00093, GTP-binding protein Der; Reviewed.	0
NC_021714.1\|WP_041702787.1\|3000151_3001504_+\|exodeoxyribonuclease-VII-large-subunit	gnl\|CDD\|234714	PRK00286, xseA, exodeoxyribonuclease VII large subunit; Reviewed.	0
NC_021714.1\|WP_012518982.1\|2988686_2989316_-\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	3.39879e-160
NC_021714.1\|WP_041703397.1\|2994102_2995005_-\|histone-deacetylase	gnl\|CDD\|212519	cd09993, HDAC_classIV, Histone deacetylase class IV also known as histone deacetylase 11. Class IV histone deacetylases (HDAC11; EC 3.5.1.98) are predicted Zn-dependent enzymes. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation). They catalyze hydrolysis of N(6)-acetyl-lysine of histones (or other proteins) to yield a deacetylated proteins. Histone deacetylases often act as members of large multi-protein complexes such as mSin3A or SMRT/N-CoR. Human HDAC11 does not associate with them but can interact with HDAC6 in vivo. It has been suggested that HDAC11 and HDAC6 may use non-histone proteins as their substrates and play a role other than to directly modulate chromatin structure. In normal tissues, expression of HDAC11 is limited to kidney, heart, brain, skeletal muscle and testis, suggesting that its function might be tissue-specific. In mammals, HDAC11 proteins are known to be involved in progression of various tumors. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients.	1.13958e-138
NC_021714.1\|WP_012518989.1\|2996933_2998511_-\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NC_021714.1\|WP_041703389.1\|2978169_2979888_+\|lysophospholipid-acyltransferase-family-protein	gnl\|CDD\|153248	cd07986, LPLAT_ACT14924-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.	1.46641e-65
NC_021714.1\|WP_012518988.1\|2995124_2996747_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	6.37647e-48
NC_021714.1\|WP_012518981.1\|2987338_2988613_-\|ATP-dependent-protease-ATP-binding-subunit-ClpX	gnl\|CDD\|235422	PRK05342, clpX, ATP-dependent Clp protease ATP-binding subunit ClpX.	0
NC_021714.1\|WP_012518978.1\|2983998_2984271_-\|DNA-binding-protein-HU-beta	gnl\|CDD\|259853	cd13831, HU, histone-like DNA-binding protein HU. This subfamily includes HU and HU-like domains. HU is a conserved nucleoid-associated protein (NAP) which binds non-specifically to duplex DNA with a particular preference for targeting nicked and bent DNA. It is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein. HU can induce DNA bends, condense DNA in a fiber and also interact with single stranded DNA. It contains two homologous subunits, alpha and beta, typically forming homodimers (alpha-alpha and beta-beta), except in E. coli and other enterobacteria, which form heterodimers (alpha-beta). In E. coli, HU binds uniformly to the chromosome, with a preference for damaged or distorted DNA structures and can introduce negative supercoils into closed circular DNA in the presence of topoisomerase I. Anabaena HU (AHU) shows preference for A/T-rich region in the center of its DNA binding site.	7.9855e-46
NC_021714.1\|WP_012518977.1\|2981795_2983688_-\|peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|182731	PRK10788, PRK10788, periplasmic folding chaperone; Provisional.	1.39459e-123
NC_021714.1\|WP_012518975.1\|2980017_2981190_-\|succinyl-diaminopimelate-desuccinylase	gnl\|CDD\|349886	cd03891, M20_DapE_proteobac, M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase. Peptidase M20 family, proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE; aspartyl dipeptidase; succinyl-diaminopimelate desuccinylase) subfamily. DapE catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelate (L,L-SDAP) to L,L-diaminopimelate and succinate. It has been shown that DapE is essential for cell growth and proliferation. DapEs have been purified from Escherichia coli and Haemophilus influenzae, while the genes that encode for DapEs have been sequenced from several bacterial sources such as Corynebacterium glutamicum, Helicobacter pylori, Neisseria meningitidis and Mycobacterium tuberculosis. DapE is a small, dimeric enzyme that requires two zinc atoms per molecule for full enzymatic activity. All of the amino acids that function as metal binding ligands are strictly conserved in DapE.	0
NC_021714.1\|WP_012518990.1\|2998581_3000051_-\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NC_021714.1\|WP_012518983.1\|2989414_2990719_-\|trigger-factor	gnl\|CDD\|234956	PRK01490, tig, trigger factor; Provisional.	0
NC_021714.1\|WP_012518980.1\|2984592_2986944_-\|endopeptidase-La	gnl\|CDD\|223542	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones].	0
NC_021714.1\|WP_012518986.1\|2992113_2992956_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293801	cd07715, TaR3-like_MBL-fold, MBL-fold metallo-hydrolase domain of Myxococcus xanthus TaR3 and related proteins; MBL-fold metallo-hydrolase domain. Myxococcus xanthus Tar3 may function as an ammonium regulator/effector protein involved in biosynthesis of the antibiotic TA. Some are members of this subgroup are annotated as ribonucleases. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	2.73399e-101
NC_021714.1\|WP_012518582.1\|2977202_2978000_+\|UDP-2,3-diacylglucosamine-diphosphatase	gnl\|CDD\|277343	cd07398, MPP_YbbF-LpxH, Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain. YbbF/LpxH is an Escherichia coli UDP-2,3-diacylglucosamine hydrolase thought to catalyze the fourth step of lipid A biosynthesis, in which a precursor UDP-2,3-diacylglucosamine is hydrolyzed to yield 2,3-diacylglucosamine 1-phosphate and UMP. YbbF belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	8.79474e-69

>NC_021714.1|WP_012518983.1|2989414_2990719_-|trigger-factor
MQVSVETTQGLERRLTITVPSDTVDSAVKSRLQQLAKTQRINGFRPGKVPVSVIKKRFGQAVRQEVAGDVMQQNFYQAVIQEKIQPAGMPKFELTKDEDGQDLEFTASFEVYPEVEVKGVSDIEIEKPVVEITDEDLDNMMETLQKQHATWKEVKRKAKKDDKVIIDFVGSIDGEEFEGGKAEDFALELGKDRMIPGFEKPLVGAKAGEEVTIEVTFPEDYHAENLKGKDAVFQATVKKVEGLDLPKVDEEFAKLFGVEEGGVDALKAEVRKNMQRELDQTLKAQVKEDVISKLVDANEIDIPQALIDQEVNALREQAKQRFSQQGGGQNLPDLPAELFTDNAKRRVSIGLLLGEVIKENELKADEAKVNEMIETAASAYEDPQEVVDYYNNNQELMQQMQNVALEEQAIEWVLEQAKVTEVTKAFDEVMNKQA
>NC_021714.1|WP_012518982.1|2988686_2989316_-|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MTNTPFDPMNALVPMVVEQTSKGERSYDIYSRLLKENVIFLVGQVEDHMANLIVAQMLFLEAENPEKDIFLYINSPGGSVTAGMAIYDTMRFIKPDVSTVCMGQAASMGAFLLSAGAKGKRYCLPNSRVMIHQPLGGFQGQASDFEIHAKEILSIKEKLNRLLADHTGQDYEKVARDTDRDNFLSATEAKEYGLVDQVLANRSDVAATK
>NC_021714.1|WP_012518981.1|2987338_2988613_-|ATP-dependent-protease-ATP-binding-subunit-ClpX
MSDKQSGDGDNKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREEIKEIAPKQKQDALPKPTEIHAHLDDYVIGQEHAKKVLSVAVYNHYKRLRNGDVHEGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVIEQRAQKDTGIGFGATVKSKDNSKQISELFKQVEPEDLVKYGLIPEFIGRLPVVTSLEELNEDALIQILREPKNAITKQYGALFSMEDVELEFRDDALNAIAKKAMERKTGARGLRSIVEAVLLDTMYDLPSMDDVSKVVIDETVIRGESKPILIYDSNEKKAASE
>NC_021714.1|WP_012518980.1|2984592_2986944_-|endopeptidase-La
MTVERENRIEIPVLALRDVVVYPHMVIPLFVGREKSIRCLEAAMDNDKQIFLVAQKDAGVDEPEADDIYTVGTIATILQLLKLPDGTVKVLVEGSVRGEIESYKQSDPFFVANVDKLEDEGIDESEQEVLIRSAVSQFEGYVKLNKKIPPEVLTSLNGIEDAARLADTMAAHMPLKLTEKQKVLEMQGVNERLEYLMALMEGEIDLLQVEKKIRTRVKKQMEKSQREYYLNEQMKAIQKELGELDDAPDEFEALSKKITDAKMPKEAEDKAKAELQKLKMMSPMSAEATVLRSYIEWLTNVPWNKRSPVKKDLSRAEGVLNEDHYGLEKVKERILEYLAVQQRVKKLKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSLPGKLVQKMAKVGVKNPLFLLDEIDKMSSDIRGDPASALLEVLDPEQNNSFSDHYLEVDYDLSDVMFVATSNSMNIPGPLLDRMEVIRLSGYTEDEKLNIAKNHLIGKQMERNGLKAKELEITDSAVIGMIRYYTREAGVRSLEREVSKVCRKAVKDILLKKSKDKVVVTQDNLKDYLGVQRFDYGKADKDNQIGQVTGLAWTQVGGDLLTIETTSVPGKGKMTSTGSLGDVMQESIKAAMTVVRSRAEKLRINDDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKCDVAMTGEITLRGEVLAIGGLKEKLLAAHRGGIKTVIIPKDNERDLEEIPDNVKKDLSIHPVKWIDDVLDIALQEPVESFEVVKK
>NC_021714.1|WP_012518978.1|2983998_2984271_-|DNA-binding-protein-HU-beta
MNKSQLIDQIAAGADISKAAAGRALDAFTDSVTAALKDGDQVALVGFGTFSVRERSARSGRNPQTGETIQISAAKVPSFKAGKALKDACN
>NC_021714.1|WP_012518977.1|2981795_2983688_-|peptidyl-prolyl-cis-trans-isomerase
MLERIREGSQGPWAMAIIALIVLSFVFAGVGSYLTSNGTTAVATVNGEEISAQELERAYQNQRAQMESQYGESIAQLFSSEQYLADFRKNVLDRLIAEKLIQQQATNMGLRVSDEQIRETIVQMPEFQFGGQFDNERFQAILRQNGFQVADFRDYLRTQMTQNQLAAALTNSSFALDGEVEQANALQRQTRNAKYVLVSSDEFADSIEVTDADIEAFYNNNIASFDTEEQVKLAYVKLSVEDLKGRVSVDEDAVRTYYDNNLGSYGTEEQRRVSHILIEAGDDADAAKAKAESLKAEIDSGADFAALAEANSDDTFSAENGGDLDFITPEMMDPAFDEAAFSLENVGDVSDVVETEFGYHVIKLTEVKEAQVKTFDEVAGEIRDTLLYDAAMEKYFELQNTLAEIAFEVPDTLDDAANAVDLPIQESVLFSRNTAPAELSSPGLLDVAFSSELVEEGLNSDIIELDDETVVVARVVEHQPQRTQSLDEVREGIEASVKAEKSKEAAESWAFDVAQKVRAGESVEDELAAKSVEWETAANVQRAGGTLARALVDTLFSLALEGDDQVDVATTVNGDVAVVMLEGVNPAPALESELGKSLKQRLAQVQGQRVYQQYIDALRANAEVTISEAL
>NC_021714.1|WP_012518976.1|2981435_2981606_+|hypothetical-protein
MLKIIVLIPLILSLLWFGYLQTKNYTLEQGKQGFLYIFVLSGVIAAFYTLMLFLTH
>NC_021714.1|WP_012518975.1|2980017_2981190_-|succinyl-diaminopimelate-desuccinylase
MSIQPSITAAPARSLHFAEVLMARESITPVDAGCQSYLMYKLEKLGFVCERHTINGVKNLIAKWGCGPLHFAFSGHTDVVPPGLLEKWKSPPFSPVVSQNKLYGRGAADMKTGISAMLAATERAIASLDEREVTYWWLITSDEEGEAEWGSKWINEYLTKRNVQLDMCLVGEPSATTQTGDTIKVGRRGSLSGTITVAGKQGHVAYPKTAVNAIHKASNIVNALTHYPFEEGSDDFPGTTLQITHMDTGSFTDNIVPSAVRIEFNVRYSWQYNQGSLAELLRQIISSVDMSALVSFSRPCEAYLSKPHNNAKRCLITSVEKAIKAATGRYPVISTSGGTSDGRFYASEKTQVVEVGVPNATIHQVNEHIHLSDLLTLEDIYTDILLNLSK
>NC_021714.1|WP_041703389.1|2978169_2979888_+|lysophospholipid-acyltransferase-family-protein
MFTVNEVLNKHYPQVANNPILFKSLSFVLRHLLHEREITEFGETYPHYEDIDFVEQVLEYFNISYSTRDVEKERIPSEGRVVIIANHPIGSLDALALIKLVSEVRHDLKVVANEMLMAIEPLHDMLLPVNNMQGGTPKQHLSAIQKHLKSDGAILIFPAGEVSRLRPQGVRDTRWHTGFLRIAKQAKAPILPVYIDAKNSPLFYGVSMVYKPLATALLVKEMFKQRKKHLPMRIGELIPFESYQQTNIPLKEQVKLFKRHLYRIGSNKKGVFETQASIAMPEDRKELSRAIRECEHLGTTGDGKSIYLYQHKSCSPIMREIGRLREVAFRAVGEGTNKRRDIDHYDSHYYHLVLWDESDLEIVGAYRFGDAELLTAPDHPTGLYSATLFNYSKNNDKLFKEGLELGRSFVQPQYWGKRSLDYLWFGIGAFLSRYPKYRYLFGAVSLSNAYPEPAKDLLVQFYSTYFPAKFGEATCKRPYQMANDALHQFTGHDYKAEFTQLKHLLANMGVNVPTLYKQYSEVAKDGGVAFLGFNVDPDFNDCIDGLVVVDMQTLTDKKRKRYLNDIQLKASA
>NC_021714.1|WP_012518582.1|2977202_2978000_+|UDP-2,3-diacylglucosamine-diphosphatase
MKKTHYRTLWLSDIHLGNRDCKAEYLLSFLNSITVDTLYLVGDIVDMWQMTKQFRWPKAHNQVMHKLMQMSQQGTRVVYLPGNHDEPIQSYSGMAFGDIEIERELVHTTAQGKRYLVLHGDQFDGDVTMGRFHAWIGDKGYDLLLFLNREFNRFRAWRKREYWSLAGYIKKHIKGANEAIARYREACCKRADEMGLDGVVCGHIHHPESTMENGIHYINDGDWVENCSALAEDENGELSLIHYLEVVESASVTSITVKDSSSKAA
>NC_021714.1|WP_012518986.1|2992113_2992956_+|MBL-fold-metallo-hydrolase
MRLIFYGVRGSIPTPGAAFVRYGGNTACVHIELEDGTDIVLDSGTGIRLLGEHLAKKNTPIHLLLSHNHWDHIQGFPFFPPIYQAEREINIYPGQTLFEEPDQILKQMEGSLFPVPRSALRANISLIEIPKADNTFAIGSAKITRLAMNHPGSGSAYCINADGVKVTYITDNELYPPYKKETDFIDFAKFAENADLLIHDAQYMLSDMPAKNGWGHSVAEEAVKLAMASNAKKLALYSHDPERTDDDIDDVVKHCNEYVTVAESTLHVFASSEGLTLDFS
>NC_021714.1|WP_012517557.1|2992991_2994011_+|phospholipase-A
MSVLKPFVFLAAFAASTSVCGQETSSDVVSTQPQIVDSSEQQISNQNETNDPSQDEEGIEVIDIIKRDTTSESALDDRLEGDKEALDNVFAITQHRQNYLLPITYVSNPNTTGNEDLTDENVDNKEAKFQVSAKLPLYLEDTGFDGVYFGFTLTSFWQLYNSEASKPFRETNYEPEIFWQETADYSVLGYKFNTFQVGFNHMSNGQSGLQSRSWNRLFASIVFSDNDDIYYLKTWYRIPEDEKEDPLDPTGDDNPDIEDYYGRMEFGYGRKIGAFKVLALLRNNLDFDENRGSIQLDLTYPISDRYEILLQYFNGYGDSLIDYNRSQERIGLGFQLLFL
>NC_021714.1|WP_041703397.1|2994102_2995005_-|histone-deacetylase
MTTPLVFHPIYSQLDLPERHRFPIEKYVGIRDELIRRGIDKARFITPSPLDFSVLTDNYDRQYVEALTSGNLDKKAMRRIGFPWSQQLIERTRTAVAGTCLTASLALQHGKALNLTGGYHHAFADFGSGFCLFNDLYLAAKTMQKSSAIDNVLIVDLDVHQGDGTAKLAENDRDIFTLSIHGEKNFPYRKQQSDIDIGLAKGTEDDEYLQTLEQALALAKRQFQPDAIIYDAGVDVHVNDDLGHLHISTEGVYERDKIVFALAEQLGVPIAAVIGGGYQRDIAALVDVHIQLYRAAGVIS
>NC_021714.1|WP_012518988.1|2995124_2996747_-|methyl-accepting-chemotaxis-protein
MFNYTSISRLVMTPVLASFFILVLLNGASILKSFSLLNAFDELENTLVQSERDVNTTLSTFKTQVQEWKNVLLRGHKKEDRVKYWERFKQREADITRQFDKMLSSAVINDSVKSNIRQFQQAHAVMAEKYREGYNAFVDSGFDPKVGDSYVRGIDREPAKLLSGIASDIASDSASAIAALKANTRSMLWVIILAAIVLSVLSVVYVIARLRSQVIKPTKEVAACISNLANSHYDYALTYTSDHELGMLANSARALQYKLKESVAQLQQAEREIDKAFGTLGNVSQSIMEGANDQRDASRSLDSSTDKLKEIVQNLVAITDQVAVATNNSEKNVASCYATFESANAGFKQLAKTVTESSDIVSDLQTRSTNILKVVNVINEIADQTNLLALNAAIEAARAGEHGRGFAVVADEVRALAAKTQQSTKEINDILSSFEAEAKGAVAAMSSGKQLSDTNAAEAATALETLNNVVKDIQETASVVVALNEAADEQEAVLHQVEMIISNVVNSSEKYHQLAQRDDMSHSMKSMSENVEKVVNSLTR
>NC_021714.1|WP_012518989.1|2996933_2998511_-|glutamine-hydrolyzing-GMP-synthase
MTTNIHDQRILILDFGSQYTQLIARRVREIGVYCELWAWDVTEEQIREFNPQGIILSGGPESVTEEGSPRAPDYVFEAGVPVLGVCYGMQTMAHQLGGGVLGSDKREFGYAQVEVIKPSPLLDKIEDAIGDNGAALLDVWMSHGDKVAAIPEGFETIAQTASCPHAAMYNEEKQFYGVQFHPEVTHTRQGMRLLTQFVMDICKCEKLWTAGAIIEDAIERIKEKVGDERVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEADQVMEMFGDHFGLNINRVDAEGRFLDRLKGIEDPELKRKAIGNEFVRVFDEEASKLENAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPEDMELGLVEPLRELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEIKKEYCDLLRRADAIFIEELYAADLYQKVSQAFTVFLPVRSVGVMGDARKYDWVVSLRAVETIDFMTAHWAHLPYDFLGKVSNRIINEIDGISRVVYDISGKPPATIEWE
>NC_021714.1|WP_012518990.1|2998581_3000051_-|IMP-dehydrogenase
MLRITQEALTFDDVLLVPGHSTVLPHTANLQTRLTRNVTLNIPMVSAAMDTVSEARLAIALAQEGGIGFIHKNMKPEEQAKHVREVKKYESGVVSDPVTVDKDATIGDVISLSKRLGYSGFPVTDKDNNLIGIVTGRDLRFEKRLELPISNVMTGKDDLVTVKEGASSDVVLDLMHEHRIEKILVVDDAFKLTGLITVKDFQKAENKPNACKDELGRLRVGAAVSVGPGTDERIALLVDAGVDVLLIDTSHGHSQGVIDRVKKVRADFPDIQIIAGNVATGDGAKALADAGVDAVKVGIGPGSICTTRIVTGCGVPQITAVSDAVEALKDTDIPVIADGGIRFSGDIAKALAAGASCVMVGSMLAGTEESPGEVELFQGRYYKSYRGMGSLGAMNQSHGSSDRYFQESNNAEKLVPEGIEGRVAYKGPIANIIHQQMGGLRSAMGLTGCATIEEMNTKAQFVRVTSAGMGESHVHDVSITKEAPNYRLG
>NC_021714.1|WP_041702787.1|3000151_3001504_+|exodeoxyribonuclease-VII-large-subunit
MFTNSPSTSRQILTVTKLNRLARTALEGEIGLIWLSAEISNFVAAASGHWYFTLKDNKAQVRAAMFKGANRNVRLRPKEGDKILVRASVGLYEARGDYQLVVEHMESDGEGALKQAFEALKFKLNNEGLFDATNKRPLPERINRIGVITSSSGAALHDVLSVLKRRSPQTEVIVYPSMVQGEAAPLQLINALRKANQRSEVDVLLLTRGGGSLEDLWCFNDESLAREIAASTLPIVSAVGHEVDFTISDFVADVRSPTPSAAAEILSQDSTALYQTINQQKQRLARAMNHCIQANKQQLTLKKQRLDALHPQSRIQSQWQTLDRLQLRLVHAMQRDMSTAEKRVHALNYRLNQQSPAARVARAKDKLSYVNAKLIATMTALLKNKKSELGGSVTLLQSVSPLSTLARGYSITLTDSTTVNNVSKVNVGDEIKTRVTDGEITSTVTNIQRQ
>NC_021714.1|WP_012518992.1|3001519_3002770_+|hypothetical-protein
MPVKVNPNSFFTLHRRALFKAPVIQGVVLLFTLYFSLSLLPSLAWGAEVNLPVSVFSTYPSDALQQSCQTQRQMDVETKTVTSFKPQHESIDGYVNESALFANNELCIEDAISPDAFIEQIIKSGVFTNLRPFGEGNDYELLIANVGPAPRATHDNLMPKDAKQYAEFTIQWRGIEIDSASFSASLNNDTNKIKSKRQGSQEGIANAQQQAPQTLVSKWLDYAERTGLFTSQYLFTALEASNYESALQVPSAVGEFTKLATQLYADPFSGAITRYTHPAYEDALIDVTVYPFLEQLTLDENELLPKQLEEDLKRAKSNAQIQKLTLSQVKPAARYKVNNQIFGWRLGLSATSESSPSIYATTYVFRRQDKIIKVSTTFPPDYSDNIVDKLIVKIEVPEESKMMKNVRALLLQRPQQ
>NC_021714.1|WP_012518993.1|3002824_3002998_-|hypothetical-protein
MSVVKSYNHTSSLQKNQVYNWYDRYKPKEQLKTYVLSEIVKPKATPKTSFIKRLSAK
>NC_021714.1|WP_012517547.1|3003477_3004923_-|ribosome-biogenesis-GTPase-Der
MLPVVALVGRPNVGKSTLFNRLTNTRDALVADYPGLTRDRKYGQAKFEKRQFIVVDTGGITGDEEGIDAEMAQQSLLAIEEADVVLFLVDARAGLLPADQGIADHLRRINKQIFVVANKVDGIDGDSESAEFYSLGLGAIKQIAAAHGRGVSQLLQDALKPLESDFPDMEIIDEAPEEEEDAESQRQRLQELPIKLAIVGKPNVGKSTLTNRILGEERVVVYDMPGTTRDSVYIPMERDEREYILIDTAGVRKRKKISEAVEKFSIVKTLQAIEEANVVLLVIDAREGITDQDLSLLGFVLNSGRSLVVAVNKWDGLSTDIKDDIKREMDRRLGFIDFARIHFISALHGSGVGNLFESVQEAYMSATKRINTALLTQIMEMAQDDHQPPLVRGRRVKMKYAHAGGYNPPVIVIHGNQVDDLPSSYKRFLMNYFRKALEIMGTPIKIEFREGNNPFEGKKNNLTLAQQRKRRRMMSYYKEKK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_021714_2	2.1\|1851867\|28\|NC_021714\|CRISPRCasFinder	1851867-1851894	28	NC_021714.1	1852122-1852149	0	1.0
NC_021714_1	1.1\|625844\|52\|NC_021714\|CRISPRCasFinder	625844-625895	52	NC_021714.1	966247-966298	1	0.981

1. spacer 2.1|1851867|28|NC_021714|CRISPRCasFinder matches to position: 1852122-1852149, mismatch: 0, identity: 1.0

ggtcaataagcttattttcaagactcta	CRISPR spacer
ggtcaataagcttattttcaagactcta	Protospacer
****************************

2. spacer 1.1|625844|52|NC_021714|CRISPRCasFinder matches to position: 966247-966298, mismatch: 1, identity: 0.981

caaggagtttcacgaggttgcctrttgtgaagagcagcgtggagcgacacca	CRISPR spacer
caaggagtttcacgaggttgcctgttgtgaagagcagcgtggagcgacacca	Protospacer
*********************** ****************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021714_2	2.1\|1851867\|28\|NC_021714\|CRISPRCasFinder	1851867-1851894	28	KJ000058	Salmonella phage STP4-a, complete genome	104880-104907	6	0.786
NC_021714_2	2.1\|1851867\|28\|NC_021714\|CRISPRCasFinder	1851867-1851894	28	CP002962	Emticicia oligotrophica DSM 17448 plasmid pEMTOL01, complete sequence	46931-46958	7	0.75

1. spacer 2.1|1851867|28|NC_021714|CRISPRCasFinder matches to KJ000058 (Salmonella phage STP4-a, complete genome) position: , mismatch: 6, identity: 0.786

ggtcaataagcttattttcaagactcta	CRISPR spacer
ggtcaataagcatattttcaaatgactt	Protospacer
*********** *********.   **

2. spacer 2.1|1851867|28|NC_021714|CRISPRCasFinder matches to CP002962 (Emticicia oligotrophica DSM 17448 plasmid pEMTOL01, complete sequence) position: , mismatch: 7, identity: 0.75

ggtcaataagcttattttcaagactcta	CRISPR spacer
tgtcaataagtttattttcaagcgattt	Protospacer
 *********.***********   .*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

963665 : 983092

Escherichia_phage(40.0%)

integrase,transposase

attL 974859:974907|attR 987907:987955

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012517123.1\|963665_964712_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_020744979.1\|965184_966339_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_015067165.1\|966908_967886_-	hypothetical protein	NA	NA	NA	NA
WP_020744981.1\|969081_970593_+	ATP-binding protein	NA	NA	NA	NA
WP_015067169.1\|970883_971582_+	hypothetical protein	NA	NA	NA	NA
WP_015067170.1\|971601_972360_+	hypothetical protein	NA	NA	NA	NA
WP_015067171.1\|972790_973420_+	hypothetical protein	NA	NA	NA	NA
974859:974907	attL	NA	NA	NA	NA
WP_015066338.1\|975107_976427_+\|integrase	tyrosine-type recombinase/integrase	A0A0R6PGY7	Moraxella_phage	2.4e-44	30.8
WP_015066339.1\|976586_977996_-\|transposase	IS66 family transposase	NA	NA	NA	NA
WP_015066340.1\|978243_978942_+	DUF3800 domain-containing protein	Q71TB8	Escherichia_phage	5.7e-93	68.6
WP_015066341.1\|978941_979415_+	hypothetical protein	Q71TB7	Escherichia_phage	1.3e-40	52.0
WP_148289231.1\|979739_980234_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_012517891.1\|980209_980701_-\|transposase	transposase	NA	NA	NA	NA
WP_015066349.1\|980798_981545_-	ATP-binding protein	K4HZD4	Acidithiobacillus_phage	5.0e-47	41.6
WP_020744983.1\|981553_983092_-\|transposase	IS21 family transposase	K4I413	Acidithiobacillus_phage	9.5e-109	43.1
987907:987955	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1012531 : 1021236

Streptococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015066371.1\|1012531_1013824_-	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	2.5e-134	60.0
WP_012517444.1\|1013883_1015515_-	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	3.2e-147	50.2
WP_015066372.1\|1015651_1018243_-	DNA mismatch repair protein MutS	A0A1V0SC35	Catovirus	6.4e-33	21.7
WP_012517446.1\|1018403_1018943_+	CinA family protein	B5TK85	Pseudomonas_phage	1.0e-25	45.2
WP_012517447.1\|1019063_1020110_+	recombinase RecA	A0A2D1GPX2	Mycobacterium_phage	2.5e-116	62.8
WP_015066373.1\|1020414_1021236_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	1.4e-26	33.2

DBSCAN-SWA_3

2096338 : 2161441

Streptococcus_phage(13.33%)

transposase,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014949331.1\|2096338_2096659_+\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	4.2e-11	43.6
WP_015067102.1\|2096683_2098960_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	7.1e-169	42.2
WP_008844395.1\|2099140_2099359_-	translation initiation factor IF-1	NA	NA	NA	NA
WP_080597398.1\|2099434_2100181_-	arginyltransferase	NA	NA	NA	NA
WP_015067104.1\|2100153_2100900_-\|tRNA	leucyl/phenylalanyl-tRNA--protein transferase	NA	NA	NA	NA
WP_015067105.1\|2100945_2101911_-	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	7.4e-59	40.4
WP_015067106.1\|2102489_2102939_+	DUF412 domain-containing protein	NA	NA	NA	NA
WP_015067107.1\|2102998_2103454_-\|protease	SprT family zinc-dependent metalloprotease	NA	NA	NA	NA
WP_015067108.1\|2103530_2105396_-	signal peptide peptidase SppA	A0A2I6UG67	Salinibacter_virus	9.7e-23	36.6
WP_015067109.1\|2105598_2105784_-	hypothetical protein	NA	NA	NA	NA
WP_015067110.1\|2105826_2106441_+	DoxX family protein	NA	NA	NA	NA
WP_015067111.1\|2106620_2107172_+	NAD(P)H nitroreductase	NA	NA	NA	NA
WP_041703247.1\|2107263_2108082_-	DUF2797 domain-containing protein	NA	NA	NA	NA
WP_015067113.1\|2108173_2109181_-	asparaginase	NA	NA	NA	NA
WP_015067114.1\|2109478_2110441_-	lipoyl synthase	NA	NA	NA	NA
WP_015067115.1\|2110433_2111105_-	lipoyl(octanoyl) transferase LipB	NA	NA	NA	NA
WP_015067116.1\|2111105_2111369_-	YbeD family protein	NA	NA	NA	NA
WP_085929710.1\|2111488_2112622_-	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	3.3e-82	44.9
WP_015067118.1\|2113133_2114102_-	septal ring lytic transglycosylase RlpA family protein	I3ULW5	Synechococcus_phage	2.1e-13	46.5
WP_015067119.1\|2114107_2115223_-	rod shape-determining protein RodA	NA	NA	NA	NA
WP_015067120.1\|2115222_2117136_-	penicillin-binding protein 2	NA	NA	NA	NA
WP_015067121.1\|2117166_2117637_-	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	NA	NA	NA	NA
WP_015067122.1\|2117752_2118070_-	ribosome silencing factor	NA	NA	NA	NA
WP_015067123.1\|2118087_2118780_-	nicotinate (nicotinamide) nucleotide adenylyltransferase	G3MA22	Bacillus_virus	2.4e-11	33.6
WP_015067124.1\|2118793_2119819_-	DNA polymerase III subunit delta	NA	NA	NA	NA
WP_015067125.1\|2119829_2120345_-	hypothetical protein	NA	NA	NA	NA
WP_015067126.1\|2120358_2122962_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	8.9e-192	42.8
WP_148289004.1\|2123241_2123769_-	hypothetical protein	NA	NA	NA	NA
WP_015067129.1\|2124088_2126485_+	ATP-binding protein	NA	NA	NA	NA
WP_041702715.1\|2126643_2127450_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_015067131.1\|2127446_2128361_+	GGDEF domain-containing protein	NA	NA	NA	NA
WP_015067132.1\|2128471_2129248_-	3-hydroxyacyl-CoA dehydrogenase	NA	NA	NA	NA
WP_015067133.1\|2129349_2129643_-	ribosome assembly RNA-binding protein YhbY	NA	NA	NA	NA
WP_015067134.1\|2129738_2130368_+	23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE	NA	NA	NA	NA
WP_015067135.1\|2130469_2132416_+\|protease	ATP-dependent zinc metalloprotease FtsH	A0A0P0BXI2	Ostreococcus_lucimarinus_virus	2.3e-120	44.4
WP_015067136.1\|2132600_2133425_+	dihydropteroate synthase	NA	NA	NA	NA
WP_015067137.1\|2133434_2134778_+	phosphoglucosamine mutase	NA	NA	NA	NA
WP_015067138.1\|2134874_2135618_+	triose-phosphate isomerase	NA	NA	NA	NA
WP_015067139.1\|2135628_2136075_+	preprotein translocase subunit SecG	NA	NA	NA	NA
WP_015067140.1\|2136435_2138730_+	EAL domain-containing protein	NA	NA	NA	NA
WP_015067141.1\|2138924_2139083_+	YqaE/Pmp3 family membrane protein	NA	NA	NA	NA
WP_015067142.1\|2139238_2139694_-	hemerythrin domain-containing protein	NA	NA	NA	NA
WP_015067143.1\|2139904_2141248_-	NADP-specific glutamate dehydrogenase	NA	NA	NA	NA
WP_015067144.1\|2141255_2142884_-	hypothetical protein	A0A1V0SBJ0	Catovirus	1.7e-07	24.1
WP_015067145.1\|2143035_2143566_+	DUF2878 domain-containing protein	NA	NA	NA	NA
WP_015067146.1\|2143586_2144291_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_015067147.1\|2144403_2145234_-	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_085929700.1\|2145973_2147141_+\|transposase	IS3-like element ISAma1 family transposase	A0A0P0I4A4	Acinetobacter_phage	2.6e-58	41.6
WP_020744917.1\|2148383_2148524_-	hypothetical protein	NA	NA	NA	NA
WP_041702717.1\|2149054_2150107_+	DNA topoisomerase IB	A0A0G2Y4T8	Acanthamoeba_polyphaga_mimivirus	1.8e-29	29.9
WP_020743511.1\|2150548_2152063_+	sodium/proline symporter PutP	NA	NA	NA	NA
WP_015067151.1\|2152079_2153189_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	5.2e-40	32.3
WP_015067152.1\|2153185_2154433_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.8e-89	44.2
WP_015067153.1\|2154563_2155514_+	mechanosensitive ion channel	NA	NA	NA	NA
WP_015067154.1\|2155560_2156115_-	HNH endonuclease	A0A1C3NFQ8	Phage_NCTB	4.6e-05	39.7
WP_015067155.1\|2156509_2158621_+	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
WP_015067161.1\|2159138_2159810_+	hypothetical protein	NA	NA	NA	NA
WP_015067162.1\|2159917_2160148_+	hypothetical protein	NA	NA	NA	NA
WP_012517136.1\|2160403_2161441_-\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_4

4366372 : 4377394

Organic_Lake_phycodnavirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012518686.1\|4366372_4369630_-	DEAD/DEAH box helicase	F2Y0S4	Organic_Lake_phycodnavirus	2.8e-09	22.5
WP_041702929.1\|4369626_4370424_-	hypothetical protein	NA	NA	NA	NA
WP_012518684.1\|4370442_4372584_-	N-6 DNA methylase	A0A220A2U4	Liberibacter_phage	5.9e-24	27.3
WP_012518683.1\|4372604_4374995_-	DEAD/DEAH box helicase family protein	Q5YA94	Bacillus_phage	1.7e-24	26.1
WP_001083515.1\|4374996_4375194_-	helix-turn-helix domain-containing protein	A0A1B1IUF9	uncultured_Mediterranean_phage	1.2e-16	56.5
WP_012518682.1\|4375443_4377186_-	DUF927 domain-containing protein	A0A1B0VP75	Pseudomonas_phage	9.3e-60	32.2
WP_043961012.1\|4377172_4377394_-	AlpA family phage regulatory protein	A0A1V0E8E5	Vibrio_phage	1.8e-08	46.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_021714

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection