CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_021915	Corynebacterium maris DSM 45190, complete sequence	2 crisprs	cas3,DEDDh,csa3,WYL,c2c9_V-U4,DinG	0	0	0	0
NC_021920	Corynebacterium maris DSM 45190 plasmid pCmaris1, complete sequence	1 crisprs	c2c9_V-U4,csa3	0	2	0	0

Cas Category Instructions

Results visualization

1. NC_021915

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CRISPR-Cas detection and classification

Crispr_ID: NC_021915_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021915_1

268314-268397

Orphan

Consensus_repeat	Method
GTGTTCCCCGCGCCAGCGGGAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021915_1

>merge|NC_021915|1|268314-268397|CRISPRCasFinder
GTGTTCCCCGCGCCAGCGGGAATGAGCCGTGAGGCCAGGTCTTCGACGGGGGCAGTCCTGCGTGTTCCCCGCGCCAGCGGGGAT

>NC_021915|1|1|268314-268397|CRISPRCasFinder
GTGTTCCCCGCGCCAGCGGGAAT	GAGCCGTGAGGCCAGGTCTTCGACGGGGGCAGTCCTGC
GTGTTCCCCGCGCCAGCGGGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_021915.1\|WP_020933675.1\|264116_264374_+\|hypothetical-protein	unknown	unknown	unknown
NC_021915.1\|WP_084482059.1\|263625_264063_+\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NC_021915.1\|WP_020933685.1\|275792_277115_+\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NC_021915.1\|WP_020933669.1\|257595_258375_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NC_021915.1\|WP_020933688.1\|279512_279752_-\|hypothetical-protein	unknown	unknown	unknown
NC_021915.1\|WP_020933676.1\|264469_264685_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|283241
NC_021915.1\|WP_020933673.1\|263086_263584_+\|tRNA-adenosine-deaminase-associated-protein	unknown	unknown	gnl\|CDD\|274869
NC_021915.1\|WP_020933684.1\|275089_275773_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NC_021915.1\|WP_020933678.1\|267617_268097_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|379804
NC_021915.1\|WP_020933677.1\|264955_267592_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NC_021915.1\|WP_020933683.1\|272011_274177_-\|catalase	unknown	unknown	gnl\|CDD\|236886
NC_021915.1\|WP_020933687.1\|277956_279102_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_021915.1\|WP_020933670.1\|258704_260315_+\|DASS-family-sodium-coupled-anion-symporter	unknown	unknown	gnl\|CDD\|273267
NC_021915.1\|WP_020933686.1\|277111_277960_+\|carboxylating-nicotinate-nucleotide-diphosphorylase	unknown	unknown	gnl\|CDD\|180612
NC_021915.1\|WP_020933671.1\|260394_261777_+\|magnesium-transporter	unknown	unknown	gnl\|CDD\|225148
NC_021915.1\|WP_020933679.1\|268566_269850_+\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
NC_021915.1\|WP_020933681.1\|270831_271392_+\|DUF421-domain-containing-protein	unknown	unknown	gnl\|CDD\|225205
NC_021915.1\|WP_020933680.1\|269849_270758_+\|tRNA-glutamyl-Q(34)-synthetase-GluQRS	unknown	unknown	gnl\|CDD\|235573
NC_021915.1\|WP_020933682.1\|271388_271898_-\|DUF3253-domain-containing-protein	unknown	unknown	gnl\|CDD\|371633
NC_021915.1\|WP_020933672.1\|262019_263048_-\|prephenate-dehydrogenase	unknown	unknown	gnl\|CDD\|235824

Protein	Function_ID	Function_description	E-value
NC_021915.1\|WP_020933681.1\|270831_271392_+\|DUF421-domain-containing-protein	gnl\|CDD\|225205	COG2323, COG2323, Predicted membrane protein [Function unknown].	2.5902e-33
NC_021915.1\|WP_084482059.1\|263625_264063_+\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	1.77506e-47
NC_021915.1\|WP_020933685.1\|275792_277115_+\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	2.16364e-157
NC_021915.1\|WP_020933669.1\|257595_258375_+\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	1.78783e-23
NC_021915.1\|WP_020933676.1\|264469_264685_+\|CsbD-family-protein	gnl\|CDD\|283241	pfam05532, CsbD, CsbD-like. CsbD is a bacterial general stress response protein. It's expression is mediated by sigma-B, an alternative sigma factor. The role of CsbD in stress response is unclear.	0.00159682
NC_021915.1\|WP_020933673.1\|263086_263584_+\|tRNA-adenosine-deaminase-associated-protein	gnl\|CDD\|274869	TIGR03941, conserved_hypothetical_protein, putative tRNA adenosine deaminase-associated protein. This model describes a protein family about 200 amino acids in length with only five invariant residues, including an Arg, a Ser-Asp pair, and two Gly residues. Members always are found exclusively in Actinobacteria, and always adjacent to homologs of TadA, a tRNA-specific adenosine deaminase from Escherichia coli. Homology, phyletic pattern, and gene neighborhood together suggest a housekeeping function in tRNA metabolism. [Unknown function, General].	4.08725e-46
NC_021915.1\|WP_020933684.1\|275089_275773_+\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	1.74274e-23
NC_021915.1\|WP_020933678.1\|267617_268097_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|379804	pfam16242, Pyrid_ox_like, Pyridoxamine 5'-phosphate oxidase like. This domain, approximately 140 residues in length, is mainly found in general stress proteins in various Xanthomonas species. It is composed of a six-stranded antiparallel beta-barrel flanked by five alpha-helices and can bind to FMN and FAD, suggesting that it may help the bacteria to react against the oxidative stress induced by the defense mechanisms of the plant.	1.50616e-39
NC_021915.1\|WP_020933677.1\|264955_267592_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	5.83493e-129
NC_021915.1\|WP_020933683.1\|272011_274177_-\|catalase	gnl\|CDD\|236886	PRK11249, katE, hydroperoxidase II; Provisional.	0
NC_021915.1\|WP_020933687.1\|277956_279102_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	5.52785e-177
NC_021915.1\|WP_020933670.1\|258704_260315_+\|DASS-family-sodium-coupled-anion-symporter	gnl\|CDD\|273267	TIGR00785, Uncharacterized_transporter_HI_0020, anion transporter. The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds].	6.72933e-81
NC_021915.1\|WP_020933686.1\|277111_277960_+\|carboxylating-nicotinate-nucleotide-diphosphorylase	gnl\|CDD\|180612	PRK06543, PRK06543, carboxylating nicotinate-nucleotide diphosphorylase.	2.33319e-139
NC_021915.1\|WP_020933671.1\|260394_261777_+\|magnesium-transporter	gnl\|CDD\|225148	COG2239, MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism].	2.52027e-122
NC_021915.1\|WP_020933679.1\|268566_269850_+\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	1.14133e-167
NC_021915.1\|WP_020933680.1\|269849_270758_+\|tRNA-glutamyl-Q(34)-synthetase-GluQRS	gnl\|CDD\|235573	PRK05710, PRK05710, tRNA glutamyl-Q(34) synthetase GluQRS.	6.46579e-121
NC_021915.1\|WP_020933682.1\|271388_271898_-\|DUF3253-domain-containing-protein	gnl\|CDD\|371633	pfam11625, DUF3253, Protein of unknown function (DUF3253). This bacterial family of proteins has no known function.	1.94266e-23
NC_021915.1\|WP_020933672.1\|262019_263048_-\|prephenate-dehydrogenase	gnl\|CDD\|235824	PRK06545, PRK06545, prephenate dehydrogenase; Validated.	4.32919e-103

>NC_021915.1|WP_020933678.1|267617_268097_-|pyridoxamine-5'-phosphate-oxidase-family-protein
MTDQQLSKETVVKQLRNADWVMLTSTGADGKLVSHPMTPQEVTDDADVLFLFSTAVSQAEALKKSNHVNIAVSETGSWLSVAATVEFVDDQAKIDELWNEDMEAYFDGRHDPNLGLLRANAESAQSWGLSGGKIENLFEMAKSRVTGDKPDGGTGTAEL
>NC_021915.1|WP_020933677.1|264955_267592_+|MMPL-family-transporter
MAQILFRLGRWSFRRKWTVLTSWLLILAGVLAAALSLSRPFTTEFAISGTPAIDAISTLDEKFPGAGDSINAASVNIVFHVPDGESVADPEHTDTIDDVVNYIEDGLGDELTGTERFGNPTTVSPELQQTVIETETEMGLPEETARIDAENVAMVSDDETIAYTTFTIDVESAQAVTDEHRQVINEAMDLGREQGMQVEAGGPGFGDPIVIKTTSEIIGLIFAFIVLIITFGSVAAAVMPVITAVIGVGIGVLLIVTSTQWIELNNITPVLAVMIGLAVGIDYSLFILSRYRDERKRMPPEEAAGMAAGTAGSSVVFAGATVFVALAALAIVNIEFLTWMGLSAAVTVAIAVLVALTLTPALLGIFGNKAFALKAPGMAGNPWRKGGKPRMQGEAVGTKWVKFVHRFPALVVAVVVLGLGAMSIPTMNLEMSLPSDSTSNKDTTQRKSADLMAEGFGEGVNSPFLVIVDAEDANPEAPALTPLMQAQSSMAGEAPDAPTEQEIAATSSFLYTVNKMQSVGGVKHAQLIAASEDGTAAQILVTPFTGPDEQVTVEVAHALRAQGEEVTDATGATIGLTGLTAVQMDITERLGGAMPLYLSIVVGLAIVLLLLVFRSIMVPVVAGLGFLLSVGAAFGLTVLVWQEGLWGLVNTPAPLISFMPIFLIGVTFGLAMDYQVFLVTRMREHYAKSGGRSTPGSKYNAVEESVIVGFSQGARVVTAAAIIMIAVFVAFIDQPLPFIQIFGFALGVGVFFDAFFIRMGLVPATMFLMGRATWWMPKWLDRILPNIDIEGTALEREFEERQKAQQRPGENAEAREKVAAGSTAASALATESSGFEAATSDARYGSRGGGTREESHGPVRREDDDDGGPSTDEMPTVK
>NC_021915.1|WP_020933676.1|264469_264685_+|CsbD-family-protein
MSNDFQNKAKEMGGRAKEAFGAATDNEKTKNEGKADQTESQAKQKMEEAGDKLKEKKDEVLGSVQDAKDNK
>NC_021915.1|WP_020933675.1|264116_264374_+|hypothetical-protein
MSFLDKAKNAARNLDKDKLHETVDKVQDKIGNEQINEKIDGVQEKLGHTGAADARDRDPQDPQRDGGVGGADNPKDDRADDPDSG
>NC_021915.1|WP_084482059.1|263625_264063_+|nucleoside-deaminase
MRRALEVARTHTPAGDIPVGAVIYGPDGRELGWGTNRREADSDPTAHAEVVAIRRAVAEYGDGWRLTDCEIVVTLEPCAMCAGALVGARIGSIVYGAAEPNTGACGSLVEVPRAPGALFVPQVRGGVLATDAASFLTDFFGGLRG
>NC_021915.1|WP_020933673.1|263086_263584_+|tRNA-adenosine-deaminase-associated-protein
MEDEGTGVSFAVTVAYGENAWQVRSFRDDFTDPQVAVDAVRNLRSEGAAFALLCVDDDYFVIVRPHPARDMFLLSDATMAVDDDFAADILDELEADVPDLDPEELDDIDGWPDGDFDVLEDLGLSEEVLGVLADDQEAWPSEQLMRIAEELGFGEELAEATGLER
>NC_021915.1|WP_020933672.1|262019_263048_-|prephenate-dehydrogenase
MTSRDVTRPICIIGLGLIGGSLLRDLVAAGHPAYGYTQSTSGMRAAVKEGFEATDDLDKALSRAEEDAALIVVAVPMGAVDATLDAIAAQAPSCGITDVVSVKTPVYEAIKARGLQSRYVGGHPMAGTEFSGWKASHAGLFHRAAWVVTYDYAAELEEAGQRVPQRWTDLFSDVVRMIINAKAEAIPTRVANHDAAVARVSHLPHVLANTLSVVGDNGGTLAQSLAAGSFKDATRVAGTEPDLQRAMCESNSEALIGALDETIELLREARASLSQETPDLTELVESGHRARTRLEARSGARKESVSPIKISSRPVLRLHPGGPGWVRQLAQTEDLGGRIEIY
>NC_021915.1|WP_020933671.1|260394_261777_+|magnesium-transporter
MSEHAQRTDRADEAITRLEQIVREGDDVAPQRAREMSTLLEAIPLKDVVNLIERLTPVRAALILRLLPRRQSIAVFDALNAGHQADLVDALGTDSLAAFFEVLEPDDRVSLLDELPAEIAELLMRSLDESDHGLTNVILGYPKGSMGRHMSPAVPMVRVTATAGDALTALREQNDRVETIYTVPVVTDDRKLVGVTSLRQLLMAAPEEPVASLMDRPIYAHTSDEDEETARWFLALDLLALPVVDDSTRLVGLLSIDDAVDIIEDADHEDTARSGGSEPLQQPYLTTPVWRLVRSRIVWLGVLAVSALLTVSVLDAFEDALAAAVVLSLFIPLITGTGGNTGNQAATTVTRSLALGDVRKRDVLPVMWRETRVGLLLGAMLGVFFGVLLGVFYGASIGVVLGVTLFAVCTLAATVGGIMPLVAKAVGADPAVFSNPFITTFVDAAGLIIYFLIAKAVLGV
>NC_021915.1|WP_020933670.1|258704_260315_+|DASS-family-sodium-coupled-anion-symporter
MSNPESTGGSTSVEELERRASGGEQTKAPDRRDWHRSLTGIILGLALAALVYMIFPQDAVETVMQSVGADPDAEYSHHAMRVVAATTVLMATWWMTEAIPLAATALIPIAVFPILQIATFSEVGSPYASATIFLFLGGFLLALGLQRWNVHRRIALGIVLLVGTSPKRLILGFMIATGFMSMWVSNTATAVIMLPIGISVLHLTAETIGGHRNQKNFATALMLAIAYSASIGSLGTLIGTPPNALLAGYMETAHDITIGFGQWMMVGVPIALIFTVIAWLVLITVFKPEMKEIPGGRELIKNELAKMGKWTYPEIMVTIIFVAAAVTWVFLPLASDWFGWDFAYDDAVVGIIAGLLMFTIPANGTTGVRLLDWKTANELPWDVLLLFGGGLSLSGMFTATGLSLWIGEVAKGLGNLPIFLLIAAVALLVLVLTEFTSNTATAATFLPIMGGVAVGIGLTTDGNEMNVMLLTIPVALSATCAFMMPVATPPNAIAYGSGYVKIGEMIKGGVWLNLIAVILITLATYFIAIPVFGLTV
>NC_021915.1|WP_020933669.1|257595_258375_+|VOC-family-protein
MRINHGDPAWLELATHDLKEAAAFYGEVFGWRWERDTASGGVTASIDGQPVARVRPALEGAPAQWTVWLKVDDVAQATSAAVGAHGNVVSPPMRYGGLGWQAVVEDPAGAEVALWEAGREDWALGSGHGRPCWFDVLSTGFDEARSFYAAVGGWRYHYTLADGTLDTSEPLQGGYRHAVNGGQGEATAGILDAWEVGGADEGSRWLMYLAVGDVDGVCAAVAAAGGEVVEGPRTMPFGRMAEIRDPHGAEFRVLRSPGA
>NC_021915.1|WP_020933679.1|268566_269850_+|tRNA-guanosine(34)-transglycosylase-Tgt
MTDTPRPAVNGSTDTTFTLGTELEKAPGRHGRTGVIHTPHGDIQTPAFIPVGTKATVKTLTPEQIRNTGAQAILSNAYHLYLQPGHDIVDEAGGLSAFTNWRGPTYTDSGGFQVMSLGSGFKKVLAMGTEGLSEADIKARDKERLAKVDEDGVDFKSFIDGSSHRFTPEFSMQIQHGLGADIMFAFDELTTLVDTRKYQEGSVERTHRWAERCLREHDRLTTERSHRPKQSLWGVVQGAQYEDLRRQATRGLIELSDAAEADGRRGFGGFGIGGALEKENLGTIVGWVCDELPVDKPRHLLGISEPDDLFTAVEAGADTFDCVAPTRLGRRGGVYTLDGRMNLTAARFKRDFRGVDEEFGGYVSENYSRAYIRHLLKANEFLAGTLCTMHNVEFMIRLVDNMRAAIEAGDFEAYRDEFLGRYYHGQK
>NC_021915.1|WP_020933680.1|269849_270758_+|tRNA-glutamyl-Q(34)-synthetase-GluQRS
MGAGRYAPSPSGDLHFGNLRTAVLAWLFARSTGRAFLMRVEDVDTQRSSMDSARRQLEDLAALGLDWDGETVYQSQRFDRYDEAIAALAARGLVYECYCSRKDIQRASSAPHAAPGSYPGTCRDLTQTQREARRAELQEQGRVPALRLRASVTSWPVTDYYVGEYTGDVDDFILRRGGNANQGQDYAYNLAVVVDDADYGVDQVVRGDDLLSSAPRQAYLADLLGFKPPEFVHVPLVLNADGQRLAKRDGAVTLREMLETRTVANVVTAIAGSVGVPGASALPEIVERFDPRALPREPYVWR
>NC_021915.1|WP_020933681.1|270831_271392_+|DUF421-domain-containing-protein
MDWLSVITPTMPVLEIIARGTVTFLLLYALLRLVGRRESASVGMTDVLVIVLIADAASTGMVGDSETLADGFLLVVVILFWSLAVDALSYWFPWFRKFAKAGPRSLIEDGELVRKTMRREFMTEGEVLSQLRMNGIEDLDQVRRVYLEGNGGISIITEDDDDSAEESAQRHGRNHPSRDVMDDPEG
>NC_021915.1|WP_020933682.1|271388_271898_-|DUF3253-domain-containing-protein
MAERTVETTDDGRYIVVNGRKWRATDPAIPEPLRKQLVSALMTGRRLVKTKGDAARVMVHDAKVALGERGDPWWEPTDDGRRERLAATMRTLLRERGEKTICPSDAARVVGADDWRDLMPLTREIAVELRDAGVLAITQKGEEVTGTDFHGPLRLAARDGLEFQPHRES
>NC_021915.1|WP_020933683.1|272011_274177_-|catalase
MTASDDKKQQDDAHVVPGAPNSITPQVEEPTTPTEPAPPKPDQKGPTPHTPAGKKLPVESEDLAQQGEYLTTAQGARLSNTDHSLRAGERGPVLLQDHHLREKIMHFDHERIPERVVHARGAAAHGVFVANGAAESVSKAGVFKKGKETEVFTRFSTVLGNRGSMDTARDTRGFATKFYTDEGVWDLVGNNIPVFFIQDAIKFPDVIHAAKPHPDREIPQAQSAHDTFWDFISLHTEAVHHMLWNMSDRGIPRSYRMMEGFGVNTFRMINDAGETSLVKFHWKPKLGVHSQVWEEAQITGGADPDFHRRDLADAIESGAYPEWDLGLQVFPDSEDAMFDGIDLLDDTKIIPEEIAPVQIVGTMTLNRNPSNYFAETEQVAFHPGHLVPGIDVSEDPMLQGRLFSYLDTQLTRLGGPNFSQIPINRPHTDVNDMFRDGFHQTAVHKGVAPYQPNSLDGGCPFMAGNEDAALIDIPAEIKEGQITRKKPESFDDHFSQPRMFYLSLSDVEKRHLKDAISFELGKCYEQAVKERMVDVLTNVDQGLAEGVAADLGLPAPAPVEVADVTTSPALSQLGKTWPIDGRQIGILTTEDSPVDEVEKLVSTIFDEGMIPLVIAPTGGKLAGSDVDVSRTYLTARSVEFDALIVADAPAVPAARVLLDEAFRHNKAIALRKDARADVEAAGVDLTADGVVTGKKLPDLLGDVKELLAAHRVWTRPVPAQQ
>NC_021915.1|WP_020933684.1|275089_275773_+|NUDIX-hydrolase
MGNDARLAVSTVIFTLREQSDVDKRAGVPALWTPFVLRTRDPYQDRWALPGGWLPDDEELEEAAARTLAETTGLHPSYMEQLYTFGRVDRSPTGRVISVVYWALVRGAEVEQAVPTENVRWYPADDLPELAFDHRQIVDYALTRLRTKVEYARIAHAFLGETFTLGQLRMVHEAVLGERVDPANFRRSALAEGDLEETGDYLAGTPHRPPKLYRYRADVDVQPGLTH
>NC_021915.1|WP_020933685.1|275792_277115_+|quinolinate-synthase-NadA
MTIQDTRSAASVDRRLKLIATGSSAGSSCSGELTSGPWEFDAPTIAHGYGPGASQADQIPAAAPRQGQIPAEYTNAPDEELHERIRAAKEELGERAVILGHFYQRDEIIQHADFVGDSFQLANAAKTRPEAEAIVFCGVHFMAETADLLSTPEQASILPNLAAGCSMADMADLDSVTECWEQLEEVYGTEPDADGRAPIIPVTYMNSSAALKGFVGEHGGIVCTSSNASAVLDWAFERGQRVLFFPDQHLGRNTGKAAGVPLEQMPMWNPNRPLGGNTEQQLEEAKILLWHGFCSVHKRFSVEQIDQARAEHPDVHVIVHPESPMPVVDAADSAGSTDFIVKAIEAAPAGSTFAIGTEINLVQRLAAEHPEHTIFCLDPVICPCSTMYRIHPAYLAWVLEELVAGNVVNQISVPDSVADPARTALERMLSVAPQQGAKKK
>NC_021915.1|WP_020933686.1|277111_277960_+|carboxylating-nicotinate-nucleotide-diphosphorylase
MSDAIRGIVAAALAEDAPHGDLTSEALVPVDAQLSASLVAREPGRFSGGEVFATVFELVDASVTVELAVTDGTAFQPGDVLATVNGPARAVLRAERIALNLVQRMSGVATLTARYVAEVKGTAARIVDTRKTTPGLRVLERQAVRDGGGHNHRFFLSDAVMAKDNHLAALSTAGVSLADALRQARARISHTTHLEVEVDRLDQLEEVLAVEPGVVNSVMLDNFELADLRRGVELVDGRLIVEASGGVTLDTVGDIARTGVDVISVGALTHSVRSLDLGLDVQ
>NC_021915.1|WP_020933687.1|277956_279102_+|cysteine-desulfurase
MIYLDHAATTPVRRSALEAMWPYLTGEFGNPSSTHGLGRAAAAGLVQARAAVAKVLGGRASEVTFTAGGTEADNLALKGFALGRPRGKHLVTTPIEHDAVLASAEYLQRIHGFEVDYLTPSVEGLIDPEELTEVLREDTTLVSIHYANNEIGAIQPIAELTAVAKQKKVPFHTDAVQAAGQLPLNVAELGVDALSLSGHKVGAPKGSGVLWSRGRYALEPVIHGGGQERGRRSGTENIAGAVALAVALSEAEAERVETAVRLSTLRDEFIDAVLSTCPGAQVSGPRQARLPGHASFVFPGVNGETVLLELESRGIVCSSGAACAAGADEPSHVLTALGMGEELARTAVRFTFGPDVTGADIDAAAQAVRESVAAVGALGGR
>NC_021915.1|WP_020933688.1|279512_279752_-|hypothetical-protein
MAHVDMWDIFREVPAEKLAGLFHRYLENNPEAELVEGKSTEELAELLVMASTGAEDDFVVTKIFDYALKFLRKEEPVSA

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Crispr_ID: NC_021915_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021915_2

1220716-1220823

Orphan

Consensus_repeat	Method
CGCGACCAGCACCACAACGACGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_021915_2

>merge|NC_021915|2|1220716-1220823|CRISPRCasFinder
CGCGACCAGCACCACAACGACGGCGGGTCCAACAGCCGCCGGGGACGCCGCAACCGCCGCAACCGCCGCGGCCGCGACCGGGATCGCGACCAGCACCACAACGACGGC

>NC_021915|2|2|1220716-1220823|CRISPRCasFinder
CGCGACCAGCACCACAACGACGGC	GGGTCCAACAGCCGCCGGGGACGCCGCAACCGCCGCAACCGCCGCGGCCGCGACCGGGAT
CGCGACCAGCACCACAACGACGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021915.1\|WP_020934552.1\|1223100_1223952_+\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|236467
NC_021915.1\|WP_020934556.1\|1226814_1227648_+\|F0F1-ATP-synthase-subunit-A	unknown	unknown	gnl\|CDD\|235617
NC_021915.1\|WP_041632129.1\|1226014_1226389_+\|hypothetical-protein	unknown	unknown	unknown
NC_021915.1\|WP_020934544.1\|1212868_1214314_+\|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|259906
NC_021915.1\|WP_041631773.1\|1228642_1229461_+\|F0F1-ATP-synthase-subunit-delta	unknown	unknown	gnl\|CDD\|237387
NC_021915.1\|WP_020934553.1\|1224015_1224702_+\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|223088
NC_021915.1\|WP_084481980.1\|1204379_1208270_-\|nitrate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|227346
NC_021915.1\|WP_041631772.1\|1208191_1209529_-\|NarK/NasA-family-nitrate-transporter	unknown	unknown	gnl\|CDD\|225133
NC_021915.1\|WP_041632128.1\|1217949_1219707_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|180167
NC_021915.1\|WP_020934557.1\|1227767_1228019_+\|ATP-synthase-F0-subunit-C	unknown	unknown	gnl\|CDD\|169138
NC_021915.1\|WP_041632126.1\|1211657_1212872_+\|hypothetical-protein	unknown	unknown	unknown
NC_021915.1\|WP_020934541.1\|1209828_1210299_+\|molybdopterin-biosynthesis-protein-CB	unknown	unknown	gnl\|CDD\|238451
NC_021915.1\|WP_020934554.1\|1224702_1225875_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NC_021915.1\|WP_020934545.1\|1214324_1214954_-\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|133000
NC_021915.1\|WP_020934546.1\|1214950_1215436_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NC_021915.1\|WP_020934548.1\|1216780_1217896_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|234672
NC_021915.1\|WP_084481981.1\|1229489_1231163_+\|F0F1-ATP-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|236448
NC_021915.1\|WP_020934551.1\|1222019_1223093_+\|peptide-chain-release-factor-1	unknown	unknown	gnl\|CDD\|234801
NC_021915.1\|WP_020934558.1\|1228070_1228637_+\|F0F1-ATP-synthase-subunit-B	unknown	unknown	gnl\|CDD\|180240
NC_021915.1\|WP_020934547.1\|1215478_1216732_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452

Protein	Function_ID	Function_description	E-value
NC_021915.1\|WP_020934552.1\|1223100_1223952_+\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl\|CDD\|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	1.13876e-83
NC_021915.1\|WP_020934556.1\|1226814_1227648_+\|F0F1-ATP-synthase-subunit-A	gnl\|CDD\|235617	PRK05815, PRK05815, F0F1 ATP synthase subunit A; Validated.	1.56563e-54
NC_021915.1\|WP_020934544.1\|1212868_1214314_+\|multicopper-oxidase-domain-containing-protein	gnl\|CDD\|259906	cd11020, CuRO_1_CuNIR, Cupredoxin domain 1 of Copper-containing nitrite reductase. Copper-containing nitrite reductase (CuNIR), which catalyzes the reduction of NO2- to NO, is the key enzyme in the denitrification process in denitrifying bacteria. CuNIR contains at least one type 1 copper center and a type 2 copper center, which serves as the active site of the enzyme. A histidine, bound to the Type 2 Cu center, is responsible for binding and reducing nitrite. A Cys-His bridge plays an important role in facilitating rapid electron transfer from the type 1 center to the type 2 center. A reduced type I blue copper protein (pseudoazurin) was found to be a specific electron transfer donor for the copper-containing NIR in bacteria Alcaligenes faecalis.	6.64804e-51
NC_021915.1\|WP_041631773.1\|1228642_1229461_+\|F0F1-ATP-synthase-subunit-delta	gnl\|CDD\|237387	PRK13430, PRK13430, F0F1 ATP synthase subunit delta; Provisional.	2.09495e-101
NC_021915.1\|WP_020934553.1\|1224015_1224702_+\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|223088	COG0009, SUA5, Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis].	2.87823e-72
NC_021915.1\|WP_084481980.1\|1204379_1208270_-\|nitrate-reductase-subunit-alpha	gnl\|CDD\|227346	COG5013, NarG, Nitrate reductase alpha subunit [Energy production and conversion].	0
NC_021915.1\|WP_041631772.1\|1208191_1209529_-\|NarK/NasA-family-nitrate-transporter	gnl\|CDD\|225133	COG2223, NarK, Nitrate/nitrite transporter [Inorganic ion transport and metabolism].	1.43605e-87
NC_021915.1\|WP_041632128.1\|1217949_1219707_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|180167	PRK05620, PRK05620, long-chain fatty-acid--CoA ligase.	0
NC_021915.1\|WP_020934557.1\|1227767_1228019_+\|ATP-synthase-F0-subunit-C	gnl\|CDD\|169138	PRK07874, PRK07874, ATP synthase F0 subunit C.	3.66442e-31
NC_021915.1\|WP_020934558.1\|1228070_1228637_+\|F0F1-ATP-synthase-subunit-B	gnl\|CDD\|180240	PRK05759, PRK05759, F0F1 ATP synthase subunit B; Validated.	1.27734e-44
NC_021915.1\|WP_020934541.1\|1209828_1210299_+\|molybdopterin-biosynthesis-protein-CB	gnl\|CDD\|238451	cd00886, MogA_MoaB, MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.	1.02351e-38
NC_021915.1\|WP_020934554.1\|1224702_1225875_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	7.82856e-76
NC_021915.1\|WP_020934545.1\|1214324_1214954_-\|NTP-transferase-domain-containing-protein	gnl\|CDD\|133000	cd02503, MobA, MobA catalyzes the formation of molybdopterin guanine dinucleotide. The prokaryotic enzyme molybdopterin-guanine dinucleotide biosynthesis protein A (MobA). All mononuclear molybdoenzymes bind molybdenum in complex with an organic cofactor termed molybdopterin (MPT). In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). This GMP attachment step is catalyzed by MobA, by linking a guanosine 5'-phosphate to MPT forming molybdopterin guanine dinucleotide. This reaction requires GTP, MgCl2, and the MPT form of the cofactor. It is a reaction unique to prokaryotes, and therefore may represent a potential drug target.	1.40129e-31
NC_021915.1\|WP_020934546.1\|1214950_1215436_-\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	5.10422e-68
NC_021915.1\|WP_020934548.1\|1216780_1217896_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	7.39588e-173
NC_021915.1\|WP_084481981.1\|1229489_1231163_+\|F0F1-ATP-synthase-subunit-alpha	gnl\|CDD\|236448	PRK09281, PRK09281, F0F1 ATP synthase subunit alpha; Validated.	0
NC_021915.1\|WP_020934551.1\|1222019_1223093_+\|peptide-chain-release-factor-1	gnl\|CDD\|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0
NC_021915.1\|WP_020934547.1\|1215478_1216732_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	1.09653e-121

>NC_021915.1|WP_041632128.1|1217949_1219707_-|long-chain-fatty-acid--CoA-ligase
MLSTMQDIPLSISRILAYGATVHGSTKVTTWSNDEAQETTFTDVAARAAAFAHALRQDLGVDGDQRVGTLLYNCAEHLEALFAATCMGAVFTPLNKQLMNDQIRHIVNHAEVEVIVADPRLMTQLSAVLVDCPSVRAVVVIGLEPLADFLPLLPEGVTLHSYEALLDGRSTKFDWPVQDERTAAAICYSTGTSGAPKGVAYSHRSVYLQAMSLRTTDSLAVEHGQSFLCCVPIYHVLSWGVPFAAFMSGTPLVLPDSDVSAPTLAKLIATTHPRVAHGVPTVWTQLMVHYLHNPPERMSLQEIYVGGSPAPPILIKMWEERYGVEVIHVWGMTETSTVGTVARPPSGVSGEARWAYRVSQGRFPASLEYRVVADDRVQAATDRNQGEIQVRGNMVTANYYRSPAEQAGGTAHQFRGKDVDDAEPQFTPDGWLRTGDVGSVTRDGFLTVSDRARDVIRSGGEWIYSVLLENVVTGNPEVVEAAVIGYPDAKWGERPLAVTVLHLDVPRTKETAEKIRERMRAQLPNWMLPEYWTFVDDIDKTSVDKFDKKDLRKHLADGKFDVITLLGPGQRSPADEPDAATDVME
>NC_021915.1|WP_020934548.1|1216780_1217896_-|GTP-3',8-cyclase-MoaA
MTSREKILLPLRTSAPSAEPLPADLPAPAADGTRALADRFGRVARDLRVSLTDRCNLRCTYCMPAEGLDWMPTEQTLNDDEMIRMITVAVEKLGIRQIRFTGGEPLLRKSLEKIIAATKELTTDEGKPVGTAMTTNGMGLARRAQKLADAGLDRVNISLDTLDPELYARLTRRDRLKDAVAAIDAAIEAGLTPVKVNAVVMPGVNEGSITELARFALQKGAQLRFIEQMPLGPPEQWERAQMVTAQDILDELATEFEMTPAEEPRGSAPAALWDVTDLTDDSVTGQLGVIASVSHPFCGDCDRSRLTTDGAIRNCLFSNSETSLRDLMRAGASDDELAEKWAGAMWVKKPGHGIDDVGFLQPDRPMSAIGG
>NC_021915.1|WP_020934547.1|1215478_1216732_-|molybdopterin-molybdotransferase-MoeA
MPHGSIARPASEHFAAVVSLARPLPPVRRAVQEALGEVLARPATAVLAVPPFTNSAMDGFLVRAADVAGEGPWTLRVVGDVPAGGSARPVGAGEAVRIMTGAPVGEDAVDQLRVIPVEDTDVAPGPGPVPAEVTVRRVSPGRAHIRGAGENIRIGDVAVAAGSVVDAGTVAALISVGVTEVDVHPAPRVAVISSGSELVAPGETPRAGQIPDSNRPMLAALATAHGAGRVVQNHVGDAEEDFAAALRTAVDEADLVVTSGGVSVGAYDVVRAVTDSPAGAGSMWFGEVAQRPGAPQGAGLWHGTPLLTLPGNPVAAFASFHAYVAPVLRVLAGHRPPADILDRPTVIARRGEEFPPVRGRTVFVPVRMEWAGGPVAYPFNGSRTGSHLVASLADTDGVAVLTEEGGDTVDVILTRTH
>NC_021915.1|WP_020934546.1|1214950_1215436_-|cyclic-pyranopterin-monophosphate-synthase-MoaC
MKFTHLNESGSAYMVDVTGKRPTVREATAQGEVVCSPEVMAALRDGTVPKGDVLAVARIAGVSAAKKVPELLPLAHTIGVHGASVELELHDDHVFIEATVRTADRTGVEMEALTSVSVAALAVVDMVKGVDRSAYLRRCGIVAKSGGRSGDWSRELPGGER
>NC_021915.1|WP_020934545.1|1214324_1214954_-|NTP-transferase-domain-containing-protein
MTAPRNLETTLAPGLDVIVLAGGRGSRMGGRDKAVVRVDGQRLIDVLLDDVSMLPGVMQVVAVSSRDPQLRPGVKVVAEEPPFSGPVAAVAAGARALATEACTHTAVLAVDAPESSGLVPELLDALDEVPEADAAAVREVSGHLQPLCAVWRTRSLHRVLDEVATDGGLTDRAAKLLLARAEVVEVVGSGEERDYDTLADLADYGEVEE
>NC_021915.1|WP_020934544.1|1212868_1214314_+|multicopper-oxidase-domain-containing-protein
MSIPIGPSGKTERAGGGRATGSKSSEWASWILIGLAVAAVVVLAVSLTTSAGQSNDAGETNTATSAAAVAAVDGETMTFEVDVQGMLFVPNRVEVPAGTELILEVTNSDSMQHDLQIRDAETGLIRPGETVTLEAGVFTESVQGTCTVAGHEAMGMTFDVVVTDAGGENAPAGADALTNPLAHVPTLAERTVDHEGFEPFDPVLPPAPTGTVHEHEWTITEEIRQIAPGHEQVVWLFDGQAPGPTLRGAVGDTFRITLHNEGTMDHSVDFHAGEVNPDEHMAQIPVGESLTYEFVAHRSGIWMYHCATLPMSLHIANGMVGAVVIDPPADSDEALSDVDEEYLLVAHEMFLGDPDVGADAQRVSDGQYDLTGFNWYPNQYNLAPLEHRVGDTVRMWLMNVGPDNPLSFHVVGESFDTVWSEGDYLIRDAGQKGTGSQAVSLLAAQGGFVEFTFDEPGTYVFVNHQMTDAEKGQRGSIVVTE
>NC_021915.1|WP_041632126.1|1211657_1212872_+|hypothetical-protein
MTVSDVSLRARGRWHTLAAAAVIWWMLVGVGVAVAHRFGASVAWWDVVHTFTVGAVTTAVIVYSTHFVEALTRTGAGRSTFVAIRVGIIQVALIALLVDRAGYDWGVLSDVAAGAVIAVLLWHIAVIVRRLRGSLAGRFAVTVPFYVAAAAFLILAILLAALAGNGVGDYSDLIGAHSRATVWGFSWLTVLGTVVTLLPTLSSTPISEVARRRCTRALSVHCAGLTAAVLLQALGLTEWAGAAQLLTVLAAVMVAQPIMATMFAGQGRWTTAAASVTAGMVWLIALSAADAASLIGGADARATTVLLAPSFLGGGLLQLVTGVLHHLLPTLIGGGPDKVRRARSLADRGGYARTVLLNLGALLALLAADGPAKEAGLILLGLGLAGHVMHIIRAVVAQYRMENL
>NC_021915.1|WP_020934541.1|1209828_1210299_+|molybdopterin-biosynthesis-protein-CB
MRAAVIVVSDRVHSGEREDKSGPRARKLLADAGIEAGREVVVPEGREAVAREIDRALADGVRLIVTTGGTGVGTRNLTPEVTAERLDCRLTGLETQVLVEGLKSSRQAGLSRGLIGLTSRDERAALIVNAPSAPGGVSDSLGVVLPLLGSIFERFQ
>NC_021915.1|WP_041631772.1|1208191_1209529_-|NarK/NasA-family-nitrate-transporter
MTTLDTSQRVLHGWDPEDPEKWDSKIAWKTLWISTITLFIGFCTWYLVSAIAPMLNQIGFDLSASQLYWLTSIPGLAGGILRLVFMFLPAVLGTRKLVTLSSLLFILPMLGWFFAVQNTDTSYWWLLTLAFLTGIGGGVFSGFMPSTGYFFPKSKSGTALGLQAGLSNLGMSFIQLVSPWLMGFTLLGIGFVAPTRSAATGEALYVYNPAIVLVPWAIVMAVIAWTQLKDVPVTANFKQQIDIFGNKNTWIMTVIYIAGFGAFAGFTAQLALLINNTFGVSSPLADTYALEDLPRGAAWAFLFPLVGAGVRALWGPLCDKFGGAVWTFIGLVGMTVSTAAAALFLNPDSPDAFTPFFIAMMVMAFFSGLVNAGSFKQMPMILPKRQAGGVIGWTGAMGAFGPFIAGVLLSLIAPATFFWGCVVFFAFAAVLAWIYYARPHAPFPG
>NC_021915.1|WP_084481980.1|1204379_1208270_-|nitrate-reductase-subunit-alpha
MRRVLRVRRRARLDLLRSASRPLPWLTGLSLTASPRLAAKDDTLTTANTQAAKPDDSNTNPLFKFGGFLRKGDVGSEGQQIFLKGGREADVFYRNRWSFDKMVRSTHGVNCTGSCSWKVYVKDGVITWESQAVDYPSTGSEMPDYEPRGCPRGASFSWYTYSPTRIRYPYVRGVLLDMYREAKREHGDPVMAWRSIVEDPAKRDAYVSQRGKGGMIRASYTEAVEIAAAAHVYTTSKWGPDRIAGFTVIPAMSQVSYGAGTRFLQMIGGVALSFYDWYADLPPASPQTFGDQTDVPESGDWYNSAYLMMWGSNIPVTRTPDAHFMTEVRYKGTKVVVVSPDFADNTVFADEWLRISPGADAALAFSMGHVILKEFHVEKQEPYFLEYMRKYTDAPFLISLDQREDGGYTAGKFLTASQLTGVDEELAGTPNAAHRLLMMEADGRVVDPGGTIADRYGDEGEGKWNLSLEGLDPVMSIADTEDFDTAEVLMPRFDLDANPDDVDGNGPIGAGIVARGVPVRRVGDQLVTTVFDVMLANYAVPRPELNLPGEWPADFHDASTPGTPAWQEGLTGVPANAAIRIGREFAQNAADSQGRSQIIMGAGVNHYFHADNIYRTFLALTSMCGTQGVNGGGWAHYVGQEKLRPQNGWSQYAFALDWQRPARQMITTGFYYLTTSQWRYDNSKASRLASPLANRDAVGDKSLSDTLIESMKRGWMPSYPQFDRNPLMLADQAEAAGMDVKDYIVSELESGNMKFAAEDPDAPENWPRILLNWRTNLMGSSAKGTEFFLRHMLGVDSDATAKELEPHERPESLVWHDEAPQGKLDLMLTTDFRNTSTTLVSDIVLPAATWYEKHDLSTTDMHPFIHSFNAAINPPWEARTDFEVFRDLADAFSQMATRWLGTQTDIIASPLAHDSADELNMANGMVPDVEKEGLQPGKNMAKLIPVERDYTKVFEKWMHFGPLTEEKGTSVHETDYDVTKQAQEMALINGASETASAGVRPDLDTEIKVIELILHLSGVSNGEVALEGFRNQGKRVGTDMTPLVAGNEQTKITWDAVKERPTEVITSPEWSADKRGGRRYTAFSINIEWDRPFRTLSGRMHYYLDHDWYIDYGEQLPIFRPPLDRLHLNGENNPGELVRGEDGNPEVTVRYLTPHNKWSIHSQYFDNLHVLSISRGGQVVWMSDKDAEKIGVKDNEWIEAYNRNGVVSARAIVSHRIPAGTVIMNHAQERTVGTPLNERSGRRGGTHNSLTRIMIKPIHVAGGYGHLTYGFNYIGPTGNNRDEVTRIRRRSQEVQF
>NC_021915.1|WP_020934551.1|1222019_1223093_+|peptide-chain-release-factor-1
MASEVSLVDDVVSEFQGIEAQMADPSIAGDQNQFRKLSKRYSELQPIIKVNDELNEVRENLEMARELAYEDHDYQSEVDRLEPLAVELEEKLADLLAPRDEQDGDDIIMEIKAGAGGEEAALFAGELARMYQRYAERHGFVWDVLDEAESDLGGVKDLTVSVKAKKPSRDGAWSVFKFEGGVHRVQRVPVTESQGRIQTSAAGVLVYPEPDEIEAVQIDEKELRVDVYRSSGKGGQGVNTTDSAVRLTHLPTGIVVTCQNERSQIQNKARAMQVLQARLEQMERDKADAEAAEGRAAQVRTMDRSERIRTYNWPENRISDHRIGYKANNLDTVLDGHMEELITALQAAERAERLEAE
>NC_021915.1|WP_020934552.1|1223100_1223952_+|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MLDQLLRRAAGRLAAAGVPSPLVDARLIAAHLLDVGHMSVHRLREEDLPAGFSADFEAALTRREAREPLQHILGVAPFGHLDLVVGPGVFIPRPETEVLADWGVRRLAGAAAPTVVDLCAGSGALALYVATLMPSARVVAVEKQVSALDWARKNVDRLAPQVELTLGDVTDPGLLPELHGAVDLVLTNPPYVPETPELDPEVYSDPPEAVFAGADGMATIDRMTGLLANLLREGGAVGVEHDDSTSGAVQEALRATGDFREVAALADLTGRPRFVTAVRGVSS
>NC_021915.1|WP_020934553.1|1224015_1224702_+|threonylcarbamoyl-AMP-synthase
MSKIYDCSDEVERAKGMRVAVDSARAGRLVVLPTDTVYGIGCDAFNNDSVANLLATKRRGPDMPVPVLIGSWDTVQGLVAEFTPQAQDLVQAFWPGGLSIVVPQAPSLPWNLGDTRGTVMLRMPLQPVAIELLREVGPMAVSSANISGKTPPISAVAAKQQLGSAVSVYLDGGEAAVGTPSTIIDISGRTPRILREGAVATDRLSEVLGMEPHVLLGRDAPEGAEGTA
>NC_021915.1|WP_020934554.1|1224702_1225875_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MAGAGVPLRELGLVLLTAAAIAFLTTGIIRWIAVKSGKVAEIRTRDVHTQPTPRLGGVAMFTGLVAAIFLAYQLPALTRGFMPVTPEMTAVLWGAAAIVLVGVIDDLIELDAVTKLIGQVIAAVIMSLLGLSWTVFYWPVGEGTTVVLSQIQGVIVTTVFTVLLINAINFVDGLDGLAAGLGMIAGGAILVFSLTVLHDQGGAVSAYPPAIIAAALVGMCAGFLPHNFEPSRIFMGDSGSMLIGLLLAAASTSASGKINMSLYGTADIVALLSPIIVVLAAVFVPVLDLLLAVVRRLASGRSPFAADKMHIHHRLLSLGHTHRRTVLVLYLWVSVVAFGAVSFSVIPPVYALALFVIMTLVAAAVTAVPVVRRRPAGQRRTKVVDRSEPA
>NC_021915.1|WP_041632129.1|1226014_1226389_+|hypothetical-protein
MRALKYGTIGLVIVTVISLAAWGGAQGLPGIWGVLIGAAVGGGYVLLTALSILVTANTSTGATGAIVLGGWLVKLVLVMIIFIALDGLTFYHQWAFVVTLLVALIVVMVAELWGLITTNVTYTS
>NC_021915.1|WP_020934556.1|1226814_1227648_+|F0F1-ATP-synthase-subunit-A
MAFKGEFYAPDLYKEFFPGFGTDGDGNWFVDTEHMFLAEFAGGAFALDRLMIVRLLMVAIMVIFFAWAMRKPKLVPSGVQNFAENVIDFVRIHIAEDSLGKKDGRRFLPLIAGIFFAVFITNISTIIPGLNVSANARIGFPLVLALIAWGAFIYAGSKKYGFFKYLKAETVVPGIPSWMHVLVIPIEFFSTFILRPFTLTVRLMANLLAGHIILVLMFSATNFFFWQLNGWSAVSIASLFGAIAFAFFEILVSVLQAYIFALLTAVYIQLALNAAEH
>NC_021915.1|WP_020934557.1|1227767_1228019_+|ATP-synthase-F0-subunit-C
MNDVILLAQDTAAAVDNTGGLKTIGYGLATLGPGLGIGILVGKALEGMARQPEMAGQIRTSMFIGIAFVEALALIGFVAGFVY
>NC_021915.1|WP_020934558.1|1228070_1228637_+|F0F1-ATP-synthase-subunit-B
MTNVYTYVVAAETLPLESQPSVLIPPLYDIVWSIIPLIIVFIVFGKLVIPKYREVLEEREDKISGGIDRAAAAEAEAQAALEKYNAQLAEARTEAAEIREDARDKGKQIQAQYRQEAEEESRRIVAAGEKQLEASREQVISELRADIGQNSVNLAEKLLGNELSENTKRSGTVDSFLSELDSVTPAGK
>NC_021915.1|WP_041631773.1|1228642_1229461_+|F0F1-ATP-synthase-subunit-delta
MHAASREALAQSESHVDELIAGAVDKVAVATTVGTDLFVVVDRLDAERSLRIAVADVSYEPQQRAGIIGQVFEGKVSESSIAVLEEAASKKWSTPREFRTGLVSLGRRALLRAAEAQGQLEQVEEELFRLSRILDREPQLTQLLSDGATETNQKRGLLANVLYGKVTMITEALALQVIGRPEHNPIDDIANLAERAAQLRDRTVARVVSAVELNEGQQAALAEKLGQIYGREMSIHSEVDPSLLGGMIIRSGHEVIDGSTQGKLARMRSTLA
>NC_021915.1|WP_084481981.1|1229489_1231163_+|F0F1-ATP-synthase-subunit-alpha
MLEESTESRKNMAELTISSDEIRSAIANYTSSYSAEASREEVGVVISAADGIAQVSGLPSAMANELLEFPNGVIGVAQNLETDAIGVVILGNFESITEGQEVKRTGEVLSIPVGEDFLGRVINPLGQPIDGLGPIESDEERALELQAAGVLDRQPVEESMPTGIKAIDALTPIGRGQRQLIIGDRKTGKTAVGVDTILNQRENWASGDPDKQVRCIYVAIGQKGSTIASVRRTLEEAGALEYTTIVAAPASDSAGFKWLSPFTGAALGQHWMYQGKHVLVIYDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDELGAGSLTALPVIETKANDVGAFIPTNVISITDGQVFLQSDLFNQGVRPAVDVGISVSRVGGAAQTKGMKKVAGSMRLELAAYRDLEAFATFASDLDPTSKAQLDRGERLVQLLIQDEHAPQSVEYQMISIWLASEGAFDLVPVEDVRRYEAEVQEHIRAAAPEVLDQIAGGQQLSDESKDALRKANEDFAATFQTTSGVSVSREPVDPLASEDVNKTALTVSRKKAAK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_021920

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CRISPR-Cas detection and classification

Crispr_ID: NC_021920_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_021920_1

4805-4950

TypeV-U4

Consensus_repeat	Method
CTCCCTGTATGCGGGGAGAGAAC	CRISPRCasFinder

2 spacers

c2c9_V-U4

The CRISPR arrays of NC_021920_1

>merge|NC_021920|1|4805-4950|CRISPRCasFinder
ATCTCTGCGTGTGGAGAGAGAACGCAGGTCTGTTCACCGTCAGCGTCTTTGACTCAGGTCGCCTCCCTGTATGCGGGGAGAGAACTTCGTGTTCGGACCCCGTAAGGGCGGCGGTCAGGGATCGTCCCTGTATGCGGGGAGAGAAC

>NC_021920|1|1|4805-4950|CRISPRCasFinder
ATCTCTGCGTGTGGAGAGAGAAC	GCAGGTCTGTTCACCGTCAGCGTCTTTGACTCAGGTCGC
CTCCCTGTATGCGGGGAGAGAAC	TTCGTGTTCGGACCCCGTAAGGGCGGCGGTCAGGGATC
GTCCCTGTATGCGGGGAGAGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_021920.1\|WP_020935832.1\|792_1008_+\|hypothetical-protein	unknown	unknown	unknown
NC_021920.1\|WP_156844894.1\|3277_3496_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226679
NC_021920.1\|WP_020935846.1\|23138_24308_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NC_021920.1\|WP_020935836.1\|3519_4107_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|349760
NC_021920.1\|WP_020935834.1\|2468_3059_+\|CueP-family-metal-binding-protein	unknown	unknown	unknown
NC_021920.1\|WP_020935843.1\|17731_17974_-\|hypothetical-protein	unknown	unknown	unknown
NC_021920.1\|WP_041632424.1\|11897_14747_-\|GcrY-protein	unknown	unknown	unknown
NC_021920.1\|WP_156844896.1\|22416_22941_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NC_021920.1\|WP_041632423.1\|9973_11581_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376986
NC_021920.1\|WP_052337840.1\|8426_8681_-\|hypothetical-protein	unknown	unknown	unknown
NC_021920.1\|WP_020935833.1\|1324_1639_-\|Lsr2-family-protein	unknown	unknown	gnl\|CDD\|378714
NC_021920.1\|WP_020935837.1\|4966_6613_-\|transposase	c2c9_V-U4	-	gnl\|CDD\|223747
NC_021920.1\|WP_020935842.1\|15600_16548_-\|replication-protein	unknown	unknown	gnl\|CDD\|309782
NC_021920.1\|WP_020935831.1\|208_796_+\|ParA-family-protein	unknown	unknown	gnl\|CDD\|349760
NC_021920.1\|WP_041632429.1\|6834_7392_-\|hypothetical-protein	unknown	unknown	unknown
NC_021920.1\|WP_156844895.1\|20797_22063_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_021920.1\|WP_156844894.1\|3277_3496_-\|hypothetical-protein	gnl\|CDD\|226679	COG4226, HicB, Predicted nuclease of the RNAse H fold, HicB family [General function prediction only].	0.000214381
NC_021920.1\|WP_020935846.1\|23138_24308_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	3.60377e-48
NC_021920.1\|WP_020935836.1\|3519_4107_-\|ParA-family-protein	gnl\|CDD\|349760	cd02042, ParAB_family, partition proteins ParAB family. ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.	3.05051e-29
NC_021920.1\|WP_020935833.1\|1324_1639_-\|Lsr2-family-protein	gnl\|CDD\|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	9.00038e-34
NC_021920.1\|WP_020935837.1\|4966_6613_-\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	9.65396e-38
NC_021920.1\|WP_020935831.1\|208_796_+\|ParA-family-protein	gnl\|CDD\|349760	cd02042, ParAB_family, partition proteins ParAB family. ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.	2.19408e-30
NC_021920.1\|WP_020935842.1\|15600_16548_-\|replication-protein	gnl\|CDD\|309782	pfam04796, RepA_C, Plasmid encoded RepA protein. Family of plasmid encoded proteins involved in plasmid replication. The role of RepA in the replication process is not clearly understood.	6.63609e-16
NC_021920.1\|WP_156844896.1\|22416_22941_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00042269
NC_021920.1\|WP_041632423.1\|9973_11581_+\|hypothetical-protein	gnl\|CDD\|376986	pfam03090, Replicase, Replicase family. This is a family of bacterial plasmid DNA replication initiator proteins. pfam01051 is a similar family. These RepA proteins exist as monomers and dimers in equilibrium: monomers bind directly to repeated DNA sequences and thus activate replication; dimers repress repA transcription by binding an inversely repeated DNA operator. Dimer dissociation can occur spontaneously or be mediated by Hsp70 chaperones.	1.37044e-21

>NC_021920.1|WP_020935836.1|3519_4107_-|ParA-family-protein
MIISVINAKGGVGKTTTAIYLASVLASRGHQIRFLDMDRQGSAMEWFERAEDNGTPLAFPVEVTIPRQLSRIARQDHNDQIIIIDTPPGDTDAIDAVIEVSDFVLVPTRSRSADMTRVWEILPLLQDRPHAVLLTFVRAGTTSLTDALTALKDNDASFLEAYIPLRESIGNSYGYAPTHFDGYEAVTDEILEALK
>NC_021920.1|WP_156844894.1|3277_3496_-|hypothetical-protein
MAPRPAQKTPTTAGDVFHSNRQSDYTTKFTVQLDTELHRKLKLAAALEERTMREITEDALAHYLNTTKSARP
>NC_021920.1|WP_020935834.1|2468_3059_+|CueP-family-metal-binding-protein
MHRFSALLAVSALALAGCTATPSPTVTAPDEVGLLAAADLTGRDVAGIIDHLDVLPANVRPEDLSAIVYSDQLVLSTPDEEISMDLPEDVAYISVAPFVTHTHDCTYHSLTTCVGEMRNARIEVTITEDDTGAVLVDETTTTFDNGFIGYWLPRDISGIITITQGEFTGSAPFSTGADAITCITDLRLQSPALQRL
>NC_021920.1|WP_020935833.1|1324_1639_-|Lsr2-family-protein
MARQQITQYFDDLDDSPLQEDEVNIIRFSVEGTDYVLDLSEDNARAFHEALEPFITAAREDAKDVLQKTDPADIRTWAQNKGMDVASRGKIPHAILQAYRDAHS
>NC_021920.1|WP_020935832.1|792_1008_+|hypothetical-protein
MSKENRFAPKKPVADAAHVEDIFVNVPTKKLSIDVDADLHKRLKLMSTLEERSMRSIVEECLTEFLDTQGR
>NC_021920.1|WP_020935831.1|208_796_+|ParA-family-protein
MIIGVINAKGGVGKTTTAIYLGCAFAAEGKPVTVIDLDQQGSASRWADLAESADDPLPFPVEVSNVGRLDKTITRAGQNAVTILDTPPGDTRSIDAAIKVSDFVLIPTQTSLIEVDRVWETLPTVDHLPHGVLITSARLGTKSLDEAVAALEANDIGVFRSRIPIRESIRASFGATPTTDEGYGSVAREILEAIS
>NC_021920.1|WP_020935837.1|4966_6613_-|transposase
MTDTSPRPPVVHRGYKLRLDPNLAQLEVLRQQVGTARVAYNMMCAYTHDIQAARDGRWKELVSTGVNFSVAWDQVKKEAKANFALQYPGYQQFSKILTQQVARHRHAAAAIEAGADPAAVWGEEERYATPWLHTAHRRVLVSGLQMCGNSLSNWLTSQSGKRKGPAMGPPQFKRKHHSRESFTIPAPEAMGPKGFATYKRGEARSGEITDYRHVRLSHMGTFRTVDSTKRLVRALRQGGKIKSYTVSRAADRWYVSFLVERPAPQNPPHPTRRQQAAGAVGLDFGVSRPVTLSTGESIPNPRHLARAEKKIKRTQRKLARTQKGSNRRRKLAQRLARHHHTVALRRHGFLHEVTTALAGGFAAIGVEDLNVAGMTSSARGTVDNPGKNVKQKAGLNRAILDVSPGEFRRQLDYKCTERGVALIAVDQFFPSSQICSACGSKTKMPLAKRVYDCQQCGILIDRDVNAAINVLREAARLAQFSLGDSSAPEGAEGKWPWTPTAHRTRPGVGDGAGVEAARPAWSQQSSNRLLVPYNVRIQSEQKHPLQVR
>NC_021920.1|WP_041632429.1|6834_7392_-|hypothetical-protein
MATVTDLVKFLSDQVFNSRQNQPVTALALLGQSGLESRGGWDEQFSSYETNLEDVNFRLRVFRRWGNALSYFRAGDRKKPAPAIEQAICYMVIYPQGKTEFFLIDHNGVMAQPIPREEIIVSTAVEESLRRFEDVDDLIPRVINFSHEDLNLSQEPKWEYYIYDVLPGHEVVFSPLKPNIDGDTY
>NC_021920.1|WP_052337840.1|8426_8681_-|hypothetical-protein
MGFNGGPSTEDLGFPAILAATFLLAVVGAIVPVEIHDPKTGKKIDTGRRMLEVLARLHQEILNAWDKKPAESDSGDAESAEEGS
>NC_021920.1|WP_041632423.1|9973_11581_+|hypothetical-protein
MQRECHHDTAPVYVPVTSDDPAPSLWSGTRRYTTEADYRGQLEAWFNAQMVTHTTGELSDRGWCHHDAEILLDHLGRDSLHCARDRSSITKAWSTTRDKHGRRTPLVWPRERAHLAEYIHFTNPSFAAVIVIDVDHVGAPGGRPSDLSLDVADKVAKLAHFNLGPNWIGINPESGKSQLIWYIDPVYRTQGTSSKPWALLEALHAELQGYFEADKNFAHGWSRNPIYTGDNLGAYCWYAQHHEVFHMRLLSAGLWMLQGETVATIEDKGVDDRKHTQRFSSGRELINAARTNTERARQARDVLAGLEDDDLSDAFAAADPDVIDGVRVVWQSPGRAQRDVTAFRHALKTGGKLHRAGKKMTDDAIIDAYRQAYEVAHSVGADGRAREEPPMKDLRSLARRVRGYVSSNKRSSDAGATEGPATGYKMSSSERKALATLGRRGGKKAAERWKDPDSAYVKDLSQKLARANKRRAAGGRSKAYEIAAYFDRVYEQTDSYPLVSDAAQEFNVSNRTVQRALEKAGIELPTGRRGKGDRP
>NC_021920.1|WP_041632424.1|11897_14747_-|GcrY-protein
MPVSPSDYLDRQTSLQRLRAFGHRWTTTITNWRESGETATEKKYAQSFWADLLDCFGIIAARQRLFEREASRASTGKHGWIDFFMPGAAIGEAKSLDVDLTAAAGQIDDYLGGGTISQAEFPRYAILTNFETIQIHKLDTTDSAVVFHVADIAAHYDDLLFLIGADTLSREEEEAASITAAELMADLYVAVLGDDEVDEPVGDDPNVPASPEDEDEREATTSILMTRLLFLLYGDDAGLWETDLFYRWVDQETTAASLGPQLSQLFELLNTPVSRRPKRLPDLLARFPYVNGSIFADEIGMEYFTPETRDALLAACRFRWTSISVSVFGAMFQLVKSKEARRAAGEHYTSETNILKTLGPLFLDDYQARADRLIRNKSSRLKDFDALMDEMAANIYVDPAAGSGNFLNLAYARLREIETALIVEKRQRFTTTGGSAMTLFIEAEQKLSIDQFHGFEIGWWPAKIAETSMFLVDHQANQKLAKAIGEAPERLPITITAHIHTGNALRLDWREVLPLPKGKTFIFGNPPFIGQYTKTDEQTADMKHVWGTDYDGYLDYVTGWHKKAIDLYRERSGEFSFVTTNSITQGQPVPALFRPVFKAGWVIKFAHRTFSWDSQAPGQAAVHCVIVGFTKDTTIKPRLWDYPDVKGEPVEQKITQGINAYLIDGPNILITKRSKVLSPELGTVIKGSQPTDGGNLVPKAGTPRPTHDSIAMKYVRYFVGAKELINGTDRWCFWMAGDDFNPGDLRKSAVLRDVTQAVQKMRAESKKAPTREQAATPHRFTEIRQFEKNYLAIPSHVSENRRYFLAQRFDPEVICGNANFQVEDPDGLQFALISSSIFITWQRAVGGRIKSDLRFANTLTWNTFPTPELTDKQRSAIITGGQKVLGARALHPDRSLADHYNPLAMSPELLSAHRALDKAVDTAFGAPRVLKNERERLEVLFARYAEMTE
>NC_021920.1|WP_020935842.1|15600_16548_-|replication-protein
MANHSPHANDGKKSNHIDIYEQLRRVQKAGILDPYAYAPADFIGIFPYSHRAGDKITLVDGDKRITLMAPDGLPYGRYPRLIMMWLGREVVRRKGTMPMDEARKIPLGKSLAHFLRECGVIKAANPDGTLRPVSTRSYRALKAQLLRLANTTIHIETTGNGAQGAATTWDNTLISEEGFFWWDILDNTDDSGEQYMLLSEKVFIRIGQSCVPVDPVHLSELSTSVAATDLYVWTTKRKSTHSGYTRVTWAQLRGQVGATFPDTDQGMRNFRKQIRLARKKVLATWPEAGIREWQGGLELVGKETAVPKKYAFPRP
>NC_021920.1|WP_020935843.1|17731_17974_-|hypothetical-protein
MRSLTGTHNDVATGQTRPKPHRVDTRSLARCQYVAMPHPQHSAVLVLDIGIPSHSASGCSEGLRPQTDALLTRWAEHGSA
>NC_021920.1|WP_156844895.1|20797_22063_+|hypothetical-protein
MARVVDVSEQVRLQVPTTPSYDVISRKRRQRNRGADAGLNKGDGWRRSGADQRLLEWSTRLGVITVRQAARYIYKGSHDYARKRVRRMAQAGLVKRLDTAPWAGTVVWPTTIGRQAATDEDSPLRVMETPADSTLPHRLLVAEEALRLLAAGKTVITEREIRLYETVSGANLDARDHFLAEAGVRRSIDGSPGVVPAVEHTEHGSVERWLTLPMPGVHTAFRIPDLLEVTDRGELRAIEVETAQKSLSRMREILTGYRDACLGHNMVPQDAGYDLPKAGALRRQFLGVRWIATEPVLIQLRGHPGGVDPVTGKDDVGLVREVWEESMNTHLFYKDKDTWALSKKNWPLRATALDVSHDPGLEYQLHQRVLPAKFRTSMQEWRVWRKVWEHEVTDDAEPVPFVQWLRAPGNLKRCREASRAL
>NC_021920.1|WP_156844896.1|22416_22941_+|hypothetical-protein
MSSSSEVTTTTSKTTTTTTSQTTTSAEPATQEAVAEQAPAEPAPIVEETSPDPAVVTDQSAVAPPVPPMMRPEDYDPYGPPKFVQCWEPNAALMSDGSIVADTVNCFNDDPAWGPPQPQTGFYEEEPNPDGCVGPAAVCGYYDEYGNPIWFDKMTGETSPRYYDEYGNPTMQRP
>NC_021920.1|WP_020935846.1|23138_24308_-|recombinase-family-protein
MARPGTLLNEDLRTPQEEIRIVRKHKHATTIQRRVQRGHRWVWDSTAEKVATERVLDDDAARWRAFENNPKLATWHSTLREPQALVKIHRSYKFVTKAQVYYGRDDTGATRWGEIEEISSPDVVRDGGAGWGFHPPAWETTPDTSVEEQNSQADENAVDGRTDTAAAATKTNDQAVAPEVDTAATPAPAADPTPAPTAPAPPPTGQKVSYLRVSSKDQSIARQREALAHLGIRKEFIDEISARSRADRPGLEACLEYLRDGDELHVASIDRLARSLIDLKELVTELTTQGVTVVFHKEGLRFAADTDDPTANLMLGVLGSFAEFERAIIRERQAEGIALAKKAGKYTGRPKALSEEQVADARRRITAGESKTSVAKALGVGRSTLYRYL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021920_1	1.1\|4828\|39\|NC_021920\|CRISPRCasFinder	4828-4866	39	NC_021920	Corynebacterium maris DSM 45190 plasmid pCmaris1, complete sequence	4828-4866	0	1.0
NC_021920_1	1.2\|4890\|38\|NC_021920\|CRISPRCasFinder	4890-4927	38	NC_021920	Corynebacterium maris DSM 45190 plasmid pCmaris1, complete sequence	4890-4927	0	1.0

1. spacer 1.1|4828|39|NC_021920|CRISPRCasFinder matches to NC_021920 (Corynebacterium maris DSM 45190 plasmid pCmaris1, complete sequence) position: , mismatch: 0, identity: 1.0

gcaggtctgttcaccgtcagcgtctttgactcaggtcgc	CRISPR spacer
gcaggtctgttcaccgtcagcgtctttgactcaggtcgc	Protospacer
***************************************

2. spacer 1.2|4890|38|NC_021920|CRISPRCasFinder matches to NC_021920 (Corynebacterium maris DSM 45190 plasmid pCmaris1, complete sequence) position: , mismatch: 0, identity: 1.0

ttcgtgttcggaccccgtaagggcggcggtcagggatc	CRISPR spacer
ttcgtgttcggaccccgtaagggcggcggtcagggatc	Protospacer
**************************************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage