CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022001	Streptomyces collinus Tu 365 plasmid pSCO1, complete sequence	1 crisprs	NA	0	1	0	0
NC_021986	Streptomyces collinus Tu 365 plasmid pSCO2, complete sequence	0 crisprs	NA	0	0	0	0
NC_021985	Streptomyces collinus Tu 365, complete sequence	19 crisprs	csa3,WYL,DEDDh,cas4,Cas9_archaeal,cas3,DinG,cse2gr11	4	15	0	0

1. NC_022001

CRISPR-Cas detection and classification

Crispr_ID: NC_022001_1

• CRISPR_ID: NC_022001_1
• CRISPR_location: 41947-42028
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_022001_1

Consensus_repeat	Method
GCAGCTTCGGCTTGTTGTCCGCGGACA	CRISPRCasFinder

spacers of NC_022001_1

>1.1|41974|28|NC_022001|CRISPRCasFinder
ACAAGGGCCGACGGTCCCGACTCGCTCG

CRISPR arrays and Neighbor proteins around NC_022001_1

CRISPR arrays

The CRISPR arrays of NC_022001_1

>merge|NC_022001|1|41947-42028|CRISPRCasFinder
GCAGCTTCGGCTTGTTGTCCGCGGACAACAAGGGCCGACGGTCCCGACTCGCTCGCAGCTTCGTGCTTGTTGTCCGCGGACA

>NC_022001|1|1|41947-42028|CRISPRCasFinder
GCAGCTTCGGCTTGTTGTCCGCGGACA	ACAAGGGCCGACGGTCCCGACTCGCTCG
CAGCTTCGTGCTTGTTGTCCGCGGACA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022001.1|WP_020945065.1|35888_36098_+|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_020945062.1|32790_33183_+|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_020945074.1|48032_48812_-|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_020945071.1|42923_44477_+|hypothetical-protein	unknown	unknown	gnl|CDD|223403
NC_022001.1|WP_158506801.1|42206_42350_+|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_020945073.1|46115_47270_-|ParA-family-protein	unknown	unknown	gnl|CDD|224113
NC_022001.1|WP_043479885.1|39515_39953_-|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_020945078.1|52228_52744_+|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_020945059.1|30692_31325_+|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_020945072.1|44892_46119_-|plasmid-partitioning-protein	unknown	unknown	gnl|CDD|275105
NC_022001.1|WP_052352411.1|36523_39514_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|315987
NC_022001.1|WP_020945064.1|35400_35874_+|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_043479842.1|49828_50815_-|ATP-dependent-DNA-ligase	unknown	unknown	gnl|CDD|185714
NC_022001.1|WP_020945061.1|32302_32773_+|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_020945070.1|42409_42931_+|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|183384
NC_022001.1|WP_020945068.1|40210_41167_-|IS481-family-transposase	unknown	unknown	gnl|CDD|366234
NC_022001.1|WP_158506802.1|47524_47698_-|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_043479844.1|50813_51023_+|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_020945060.1|31317_31545_+|hypothetical-protein	unknown	unknown	unknown
NC_022001.1|WP_020945063.1|33196_35416_+|hypothetical-protein	unknown	unknown	gnl|CDD|214640

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022001.1|WP_020945072.1|44892_46119_-|plasmid-partitioning-protein	gnl|CDD|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	2.40558e-12
NC_022001.1|WP_052352411.1|36523_39514_-|tetratricopeptide-repeat-protein	gnl|CDD|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	5.52735e-11
NC_022001.1|WP_020945071.1|42923_44477_+|hypothetical-protein	gnl|CDD|223403	COG0326, HtpG, Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones].	1.40769e-14
NC_022001.1|WP_043479842.1|49828_50815_-|ATP-dependent-DNA-ligase	gnl|CDD|185714	cd07905, Adenylation_DNA_ligase_LigC, Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases. Bacterial DNA ligases are divided into two broad classes: NAD-dependent and ATP-dependent. All bacterial species have a NAD-dependent DNA ligase (LigA). Some bacterial genomes contain multiple genes for DNA ligases that are predicted to use ATP as their cofactor, including Mycobacterium tuberculosis LigB, LigC, and LigD. This group is composed of ATP-dependent DNA ligases similar to Mycobacterium tuberculosis LigC. ATP-dependent polynucleotide ligases catalyze phosphodiester bond formation using nicked nucleic acid substrates with the high energy nucleotide of ATP as a cofactor in a three step reaction mechanism. DNA ligases play a vital role in the diverse processes of DNA replication, recombination and repair. Members of this group contain adenylation and C-terminal oligonucleotide/oligosaccharide binding (OB)-fold domains, comprising a catalytic core unit that is common to all members of the ATP-dependent DNA ligase family. The adenylation domain binds ATP and contains many of the active-site residues. The common catalytic core unit comprises six conserved sequence motifs (I, III, IIIa, IV, V and VI) that define this family of related nucleotidyltransferases.	3.76177e-67
NC_022001.1|WP_020945073.1|46115_47270_-|ParA-family-protein	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	2.20762e-34
NC_022001.1|WP_020945070.1|42409_42931_+|RNA-polymerase-sigma-factor	gnl|CDD|183384	PRK11924, PRK11924, RNA polymerase sigma factor; Provisional.	3.82932e-14
NC_022001.1|WP_020945068.1|40210_41167_-|IS481-family-transposase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	1.84112e-20
NC_022001.1|WP_020945063.1|33196_35416_+|hypothetical-protein	gnl|CDD|214640	smart00382, AAA, ATPases associated with a variety of cellular activities. AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.	7.85688e-06

Protein sequences

>NC_022001.1|WP_020945068.1|40210_41167_-|IS481-family-transposase
MSHRNARLTIHGRRLLAERVRSGRPVAHVAAEMGISRATAHKWIRRSRTEGEAGLADRSSRPRTTPHRTPATVEARVCQLRQARKLGPALIGPALGLPASTVHRILVRHALNRLAFLDRPTGQAIRRYERARPGELIHVDVKKLGRIPDGGGHKVLGRQAGRATRSRMGFDYVHSAVDDHSRLAYSEIHPDEKAATCAAFLRRAATFFAAAGIDRIERVLTDNAWPYRKSFAWQQALTDLGAAGKLTRIYRPQTNGKVERFNRTLLDEWAYLRPYQTNDERNQALADFLHTYNHHRCHTALGGHPPISRVNNAAGQYS
>NC_022001.1|WP_043479885.1|39515_39953_-|hypothetical-protein
MEAKVTLAEALRELRRELYAAQDDGAGQQLRFEVEQAQLTLDVEFRRDGDGKVKVEVGLPGVKAGAETGGTLEATHRQTLTLSLQVLDEALGGSRAKIRRPSAEDGASATAAKSTGAEAPEQSTSAEAPDETSGSGTGAKRPWEQ
>NC_022001.1|WP_052352411.1|36523_39514_-|tetratricopeptide-repeat-protein
MDARRLVWVRTGHPGGSGSGYLIGPQLVLTALHVVLPDQRWALQVQARVGHPRFGKVVHRRAEVCWPDPLEGVPAEDALDMALLWLEEPVSVESDPVRWGRPGGIVPLPFEGAGFPAFADEAARGDVEHLRGELPVVSTSSSDWVLDCRVWPDLGHGGERLWAGASGAAIFCRGRLVGVAVEDNRPMGGRRLQAAPVHEALSLPGFADLVTRHGHHPGTTVSLEEITAAQADTGRNEAPVTQPVVPVPIPQLATAFQPRSVLWDQIDAAWSDNRSVVLTQEQPRVLSGGGGVGKTQLAAAYATNAVKNRTDLVLWVAAAEVQQVTTLYAQTASTLKLPGASGEDLEADARLLLDWLRNTSRRWLVVLDDITDPYGIQPLWPASQTGSGRVLATTRSRDACLTGNGRIRIDIDVYTPAESGTYLHQRLSAENMGHLLDDHTTQLTHALGHHPLGLGMAAAHMINEELTSTQYLARYNDRHRLLDEVMPPAADTEGYLEPKQPTQVTAALLLSLDAVQASDTTGFATTALRLTALLDPAGHPHALWNTPALLDRLTIHHTPVSQGDATASHAPATAEQAHAALRLLHRYALLTCDTRAEPRAVSIHALTARAIRETIAADEIPALAAAVADGLLQLWPDPDQHHAEHAAVLRANTSALSSHSNDCLWHPDRHPVLYRAGNSLLNAGLAASATAYWQHMILESERLRGGEHPDTLTARGNLASSYQQAGRTSEAIQLLEQVAADTKRLLGSEHPHTLTARGNLAASYQQAGRTSEAIQLLEQVAADRERLQGSEHPHTLTAHANLAATYRQAGRTSEAIQLLERLAADTERLLGSEHPHTLTDRGNLAASYRQAGRTSEAIQLLERLAADTERLLGSEHPHTLTARGNLASTYRQAGRTSEAIQLLERLAADTERLLGSEHPHTLTARGNLAATYWQAGRTSEAIQLLEQVAADRERLQGSEHPSTLTAHANLAHARDAAAAVQRPDAETPTWRGMRGQ
>NC_022001.1|WP_020945065.1|35888_36098_+|hypothetical-protein
MSFSFTNPEPDRDDRSFSFTGTQPDCDDGRSFSFTGSDPAVIDRQLQAITDMAHEILRLVENVRRQINT
>NC_022001.1|WP_020945064.1|35400_35874_+|hypothetical-protein
MEGSMNTRTDTDFTPIDQDLYAKAFQLLDPGPTPEPTATEASAASVPSPRPAAPPVRRTGPVERTLTDALAFLDTHGWARFTLVHPEGARCSIGALRAAAGARNAAYCDAGNLLLDEARRQHGKKWETIPSWNDSHTGAQVRSVWDAAIRRARRMSI
>NC_022001.1|WP_020945063.1|33196_35416_+|hypothetical-protein
MGPTRAQFIQYAPAALAVVPLVAGPWSALAAAAAGAGAWTVGVSAPVLRSLIGCGFTATGCGIAAHEVLAAGGTPLIALGLAVPAGAAALAHRRNIADHTPALVPATTTTGAGAAVGLTSQAQLITAWWKEFISGPTQTEDRKLIQVGANLEHLALEADDDHVSFTGIITLPQGQQVRVRAADIAAVYQIPVSQVELGDPKHYAPNALPVTVQLKVPAAQPQIVAGTPTTPEEVWAAYVAVPEGAMPGTTLTVTRYDGPLDWEGIATRDRRAIGTVNLQDLAGNLELETIQIALAPGDKPSQMGIRVMREHALMHGTMLSSVVDELSMDSRGYIRAGTYVDGRPALLPLAQPGSGARHLYLVGGSRSGKSGLLEQILLSAHRSRIAVVLASPQAGTIAGASLSAYLGDGLDEAMGALRLAYAMMLDREARYRSPAFPFTDPLVLVVIDEAHMLLSVSSPYHLEAKAIVEQLTRRSLKRGIGVVLATQTPLAEDLGNSTVIRSQLLIGGGAVFLRCARGQGNLVGANAVEGAEGIDLSMIPSQWPGQYAKVSNRDMSGLATEAAAAPEDGTFGLGYLLTPGSQAIQFRSLHLDVAPVSLAGGEPPVGIENCDAWRERDAITQTPMVDKRGKNLIGSLTDLLAAAQGAPSSHEAPQDNSSGLQTIAGSSRPGAPGAAAGAPDGQELIKPRILELLREQSIPMTAETIARKLGTSAKNIKPRLSELKKRDEVTNENGLWRAA
>NC_022001.1|WP_020945062.1|32790_33183_+|hypothetical-protein
MSTTETLKDAANYAALRTKLAWLTHKVHAHAQTVTTLASDVDDAAEQMLDAAETMKALAVDDATTAEFADAALTMTGVKDAAGAYTSAADSASAAADDAKATTENDHGGIADAVTTSPVDMAEATFYTQQ
>NC_022001.1|WP_020945061.1|32302_32773_+|hypothetical-protein
MQPNPPVPHSATVDDKGTHVTTAAGKTRTYSGGEVMTLTQVIDLAEGSATLCQSSTETCLDLMDEAAELATDCDTLIAEITAQGVGANLLGKCEVLKEQLDLQAAAAKDLHDKIQGGEEACRTASANAELRHGPIFRAVADSPLTKPAERDFYNAR
>NC_022001.1|WP_020945060.1|31317_31545_+|hypothetical-protein
MPDMTLQFFALALFCWAVFFTFKKTKGKQMVICIMLIVSGIFLPYTPFSEQIRTTLESVFNTANTTVNNISSSSR
>NC_022001.1|WP_020945059.1|30692_31325_+|hypothetical-protein
MSGIDWDKEFSLMNPQTPPTSEKPEKPAISRLSTAVGGMRRNTAALAVCGTIAVVAVCGTVVAVTSMQGEQAAQERARAKEKAANALVEAEADKQRAQTEEAAAKVTYEREMTVYRECMKSRAAAVAKAASYDVARIPTCDAPTLGGAASQSQKSAGSGGGLGGITSSPWLWVALVGGGGFIAYKKLSAPSGSGAVTPTNDKGFTFEKGA
>NC_022001.1|WP_158506801.1|42206_42350_+|hypothetical-protein
MAVKIAILHGSAAALATVYTTTNSLAVTILTAVVAVGLAWMLDRHRG
>NC_022001.1|WP_020945070.1|42409_42931_+|RNA-polymerase-sigma-factor
MPSAHEDKFDAFFRREISLLVRHLVVQGFGRQAAKEAAQEAMIELHEQWSNVRNPAAWVRIAARRRALRGREQEVRCDVVSVMAAALCPDIDLRTPEEEVTRKQEWQEVLGLLGALPRVQQQIMAWTWDGAKPAEIAVRLGIPADTVRSNLRHARNRLKQLWAESREEESNDG
>NC_022001.1|WP_020945071.1|42923_44477_+|hypothetical-protein
MDESDNELASSAAFNSWLNRVGDDLAASLISAEETEEMLRAVKRASSASGTSSAFHTAVARTGTDTYTALQTMVTWRNPSVSTAAEEGDLYGAPFINTPAASPSDTVTDDADLRRSTGIRLRVVESSPGKAEPAPIAPAHEPARGKEQEPRERYRLNDESVRELLLGTHLYQDRGVAIRELYQNALDALRYRTARYEYLRRRTGSSVPWQGGIEFVQGVDDRGRAFLDCVDNGIGMGDEELRTCFSRVGVRFASQPEFVQETSEWERCNPPVHMYPTSRFGIGVLSYFMLADEIEVTTCRMDQRGAAGPVMKLTVLGSGQTARISRVQAQGRAPGTRVRLFIRDEQNTPSCVDVLEQLLCIADYTTTARHGTQSAVWEPHEWARQMAPHHAHALNVRGRLIRTLKGQVTWCESGGALLVDGLLVQPSVRHGLLADSHGPNGFHGAVINLSGPSAPALSVDRKHIQDDVSPKVELLVASAARELVSTRRDFVTDAWLDSLNGHSPRLAAIVKQAASEA
>NC_022001.1|WP_020945072.1|44892_46119_-|plasmid-partitioning-protein
MSSIADKLGTGSSFGQARRERSARGRAKAITEGEIPSYELVRLRLDQVSSTPLNPRRNFGTDDEMTRFGEELRQAQLAACVAVTRDAYLALWPDHEQRIGSALHVLVNGERRFRSAVHVGLDALDFVIRNDLASSREQFIKHLLEENLSREDFDVIERARGVEQLVSVCAEGAGRGARSRAAEQLGRDRSWVTNQLVLLTLPVEIQAMLSAGTVSERDGRAAARHLKDNPRLDAADLLQYLQETKDAAAQVKALEKEAVAAAREGLLSADNKPKVPSQASPEESAAAMAPAEAASAPGEGHQGLLSADSKPGKSSTLVTAPGGDTGQRTQSMVVSDADESRTDASSSQASAQSRPLPYDDPGHIAMLLKVKMEPPAFAKCTRMMLNALRDQQPDAFAALVRELAEQPT
>NC_022001.1|WP_020945073.1|46115_47270_-|ParA-family-protein
MTAPYDPTDREKVVAKLPADLRKELKVRAAELDRDIQDAVTEGVEAWRKARPRPEVDTSGGSSFSTYLPAGLYGRLKEVSKKRGISYNQGVAQAIRLWLDSNPSPRPKPARVTGARRVIFGNQKGGVGKTSVAAGTAQALAESGHRTLLIDFDPQGHLTVQLGHKMLDIDSPSLAKHMLGEAKGELRDLLVPIRGGDFEDHLWLLPSCKDAFLLDAKLATSRFVRVKETALEKALEQLEKQFDFIVVDCPPSLGYSMDTALYYCRTREGEEDKTSGIVVVVQAEDSSADAFDMLDDQIQDLTGDLEVDISMLGFVVNLYDARKGYVATSSLEEWRKIGDPPVVAVVPELKDQREAVRVKQPLLVHAPYGEQAEVMRTVARRISA
>NC_022001.1|WP_158506802.1|47524_47698_-|hypothetical-protein
MSTLALLVTVLVGLAFVVVPAAVAYLAYRHPSARGPMGIGIAAVAAMAAIIVPIALR
>NC_022001.1|WP_020945074.1|48032_48812_-|hypothetical-protein
MRAPLQATTDGRILFVTATADGLRMDEARRLRRKDYYWGPSASDTWQGVPSLVQALRLRGRESGLPQKIYLFPPPRVETRKLMDRFAAEVLVLPRNERWREALSTALLGDWCEPLLRTGRLPDTALGALKAEARAVHRQLMPVWRRRTRHGRVLSLDADLGGLSLYELVSVEVDYLAHTAGGVFEDERLNRVLRGLDQAERQVVFAYAEGLGTSWAEAAASVGVAEPEAFGERVRRKVHRLVGEQRRRAAQRCPRSPAT
>NC_022001.1|WP_043479842.1|49828_50815_-|ATP-dependent-DNA-ligase
MTWTLPEPMLATSVSDPALPPGHAAEPKWDGWRALLSRDAHRLILRSRRGTNLEPCFPELRASAAQLPDATALDGELVVWDAAGRLAFERLQGRLQRRGADALRLAEQWPAHFVAFDLLRLSGSDTTRWSYSRRRAALENLFTDHRLTAPWVLCPSTTDPATVREWLTNWTAVGLEGVVYKRLEGKYEPSVRGWRKYKARETEDAIVGAFTGSPAAPRTLLLGRYNTDGRLHYVGRSTTLPQTAGRAVAGLLTPAGDDHPWRGWTFSAGWGSRESLHVALVEPELVVEVSVDVARDGAGRWRHAASWHRARPDLSPADVPVVEPGAAG
>NC_022001.1|WP_043479844.1|50813_51023_+|hypothetical-protein
MGDAFLELLLALYLIGWRACSGRRRTCRLGFVPVPEVPDGLIMSERFVEQERAKLAGLTGMEYGTQWRR
>NC_022001.1|WP_020945078.1|52228_52744_+|hypothetical-protein
MRRFTATFTALALGSAGLIAATAGTAQASTCSHAYLPLPDSSCTPGAYNPDVTQSNIHSTICVSGWTATVRPPTSYTNPLKAQGITDYGYADTNMADYEEDHLVPLELGGAPRDPQNLWPEPYSGSQTAHSKDGVETKLKNAVCAGIITLSAARSAIKNNWTTALQVTGIG

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022001_1	1.1|41974|28|NC_022001|CRISPRCasFinder	41974-42001	28	NC_022001	Streptomyces collinus Tu 365 plasmid pSCO1, complete sequence	41974-42001	0	1.0
NC_022001_1	1.1|41974|28|NC_022001|CRISPRCasFinder	41974-42001	28	NZ_AP017976	Microbacterium sp. TPU 3598 plasmid MST3P, complete sequence	19478-19505	7	0.75

1. spacer 1.1|41974|28|NC_022001|CRISPRCasFinder matches to NC_022001 (Streptomyces collinus Tu 365 plasmid pSCO1, complete sequence) position: , mismatch: 0, identity: 1.0

acaagggccgacggtcccgactcgctcg	CRISPR spacer
acaagggccgacggtcccgactcgctcg	Protospacer
****************************

2. spacer 1.1|41974|28|NC_022001|CRISPRCasFinder matches to NZ_AP017976 (Microbacterium sp. TPU 3598 plasmid MST3P, complete sequence) position: , mismatch: 7, identity: 0.75

acaagggccgacggtcccgactcgctcg	CRISPR spacer
gacctggccgacggtccagcctcgctcg	Protospacer
.    ************ * ********

2. NC_021985

CRISPR-Cas detection and classification

Crispr_ID: NC_021985_1

• CRISPR_ID: NC_021985_1
• CRISPR_location: 166980-167054
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_1

Consensus_repeat	Method
GCTCCGGCGCTTGCTCCGGTTCTGGCT	CRISPRCasFinder

spacers of NC_021985_1

>1.1|167007|21|NC_021985|CRISPRCasFinder
CCGGTTCTGGCTCCGGCGCTT

CRISPR arrays and Neighbor proteins around NC_021985_1

CRISPR arrays

The CRISPR arrays of NC_021985_1

>merge|NC_021985|1|166980-167054|CRISPRCasFinder
GCTCCCGCACCCGCTCTGGCGCCGGCTCCGGTTCTGGCTCCGGCGCTTGCTCCGGTTCTGGCTCGGGCGCTTGCT

>NC_021985|1|1|166980-167054|CRISPRCasFinder
GCTCCCGCACCCGCTCTGGCGCCGGCT	CCGGTTCTGGCTCCGGCGCTT
GCTCCGGTTCTGGCTCGGGCGCTTGCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_106960520.1|177980_178331_-|hypothetical-protein	unknown	unknown	gnl|CDD|375043
NC_021985.1|WP_020937469.1|167186_167513_-|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NC_021985.1|WP_158506725.1|173501_174116_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225107
NC_021985.1|WP_020937465.1|162864_163818_-|potassium-channel-protein	unknown	unknown	gnl|CDD|223643
NC_021985.1|WP_020937464.1|161708_162806_-|winged-helix-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|377630
NC_021985.1|WP_043477071.1|166125_166944_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|272862
NC_021985.1|WP_106960518.1|172279_172906_+|anti-sigma-factor-antagonist	unknown	unknown	gnl|CDD|132914
NC_021985.1|WP_020937474.1|176297_176831_-|2'-5'-RNA-ligase-family-protein	unknown	unknown	gnl|CDD|379265
NC_021985.1|WP_106960646.1|157278_158211_+|NADP-dependent-oxidoreductase	unknown	unknown	gnl|CDD|176191
NC_021985.1|WP_020937463.1|161343_161556_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_078614862.1|159296_161033_-|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NC_021985.1|WP_043477068.1|158306_158738_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_021985.1|WP_158506727.1|175754_175925_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020937471.1|173020_173389_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020937476.1|178592_178952_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043477077.1|177145_177481_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_162473327.1|158867_159011_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043474429.1|164091_164808_-|DUF1345-domain-containing-protein	unknown	unknown	unknown
NC_021985.1|WP_162473328.1|174559_175282_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020937467.1|165020_165425_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_043477068.1|158306_158738_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.50753e-11
NC_021985.1|WP_106960520.1|177980_178331_-|hypothetical-protein	gnl|CDD|375043	pfam17196, DUF5133, Protein of unknown function (DUF5133). This protein of unknown function is part of the Borrelidin synthesis genomic cluster. Borrelidin is a polyketide antibiotic.	0.00160736
NC_021985.1|WP_020937469.1|167186_167513_-|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.43139e-14
NC_021985.1|WP_158506725.1|173501_174116_+|helix-turn-helix-domain-containing-protein	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.44303e-38
NC_021985.1|WP_020937465.1|162864_163818_-|potassium-channel-protein	gnl|CDD|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	6.21914e-32
NC_021985.1|WP_020937464.1|161708_162806_-|winged-helix-DNA-binding-domain-containing-protein	gnl|CDD|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	4.21819e-45
NC_021985.1|WP_043477071.1|166125_166944_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	4.77603e-86
NC_021985.1|WP_106960518.1|172279_172906_+|anti-sigma-factor-antagonist	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.96511e-25
NC_021985.1|WP_106960646.1|157278_158211_+|NADP-dependent-oxidoreductase	gnl|CDD|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	5.78085e-96
NC_021985.1|WP_078614862.1|159296_161033_-|SpoIIE-family-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	8.80932e-30
NC_021985.1|WP_020937474.1|176297_176831_-|2'-5'-RNA-ligase-family-protein	gnl|CDD|379265	pfam13563, 2_5_RNA_ligase2, 2'-5' RNA ligase superfamily. This family contains proteins related to pfam02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.	5.28921e-07

Protein sequences

>NC_021985.1|WP_043477071.1|166125_166944_-|class-I-SAM-dependent-methyltransferase
MWATAVGVARVRALETERADPLFRDPLARAFAAAGGLWPSSPPPPQGDEAARRRRLAVAFSIVIRTKYLDDLLHQACASGIRQVVLLGAGMDSRAFRIDWPEDTRLFEVDTAQPLDFKDQVLRQEQAVPRCRRIPVAVDLREDWPQALAAAGHDPATPTVWIAEGLLIYLPRDAVDLLLSRIGARSAPGSRMGLTLGSRGVIERFGADAAPGSAASLWVSEMPDDPVGWLAGHGWDAETHTLRERAAAYGRPAGTPPSHEEGPGGLVSAVRR
>NC_021985.1|WP_020937467.1|165020_165425_-|hypothetical-protein
MRAGRRFSPLPRYRGVWAAGLTALPALFALSAVTPAAAAVPAHHQQAQPHPRYVQVSNTQTCNPDGLCTITATCPSGTVVTGGGVSETPLISSGVYLMETEPTSSRTWRGTLRNASQFPVQVTVTAVCARIPGV
>NC_021985.1|WP_043474429.1|164091_164808_-|DUF1345-domain-containing-protein
MARTRTQASTRHPRHERRGEARLPAVVATLAAIALYLLLPQRLLIAPRYVLPALECLLLIPLIAINPKRLTRQTKTFRVLSLTLVGVIAISNLVALAILIHELVYAGVKDGRSLLVAALQVWLTNIIVFGLAYWELDRGGPVSRTQAPRSALPLADFRFSQDENDDAVQEVADGASATSDWVPTLVDYLYVSTTNSTAFSPTDTMPLSTRAKAMMSIQSIAALLTSLLVIARAVSILH
>NC_021985.1|WP_020937465.1|162864_163818_-|potassium-channel-protein
MLLAAFALLALLAAGVGGYTLFGFSLPDAVYMTVMTLTTEGFSGADRLTEAGKLFTAALAVVGVALFVAVLGLIGTALVEGRFGPAGRKRRMQHRIDTLRDHFIVCAYGRVGQAVAREFEAEGVPFVVIENKTALEEQLQRERAPYLIGNAASEQVLRRAGIAHARGLVCAVDSDAENVYITLIAHSLNPSLAIVSRASEAASAERLTHAGASSVVSPYITSGRRMALLAVRPHVVDFLEFTRAGSSDVRIEEIRFDTGSRLVGRPLRQACGGALPLLIRRADGTLEPNPDPDTAVQAGDTMIVFGDPGALRPIEDD
>NC_021985.1|WP_020937464.1|161708_162806_-|winged-helix-DNA-binding-domain-containing-protein
MPEYDRVRLRRACAQALAGGVREATAEAVVRRVCALQAQDAMAADLGIRARGADITAPAVRAAYEDERSIVRGWYLRGTLHTVCSEDARPLLALLAPRILAATGRRYHQLGLHEELRRRADHLIRQVLSTHGPLTRAELTGHLTPLGIPPDGQAPFHLIRHAALTGVLCHGPRRAGEATYVLLDDWLPRGGGRREADGDAALAELARRYLAAHAPAGPQDFAVWSGLPLSWARRAWNTLARAAAITADGDLTTLAARAGKREYPPDAPGAPGAPDVRMLPALDNYLLGYRSREACVPAAHEADVWPGGGVIRPTVVADGLVVATWARRDAGRSITVRAFAPLPPGTRAAVDAETEDVSRFCRRSA
>NC_021985.1|WP_020937463.1|161343_161556_-|hypothetical-protein
MIVKKLHESGIRAEHAYAAAFVSIGLSVISWAASLQVEKKGEERADRWGIFVGEWAPTFFGLGLALSTYE
>NC_021985.1|WP_078614862.1|159296_161033_-|SpoIIE-family-protein-phosphatase
MSASADAGMDRFARLVANVLDVPVALVALAEDGRQVFPGMAGAGRPWSVSRQAALADSLCALVVGSGAPLVVSDARTDPRTRSGPVVTHLRAAGYAGMPLTDPHGTVLGALCAVDTRPRRWSEREVQALEDLAAACTAELRLRIVSRQAEEARAETAALLARSELVLRASEVLADTAGVEEVRTQVGELITSDLKPVYVGFSLEPAPRPGRARGPARAHPQAPQVDPDDGAWPTARAVRDKRLVEVHGVDEVRAAYGRHAAARWESLGFASMVCLPLAGTHRTLGALALAWDTEHRPDVAERAVLYAVSGYAAQALERAQFLDDRIDVARRLQEAMLTDLPAVDGLATAALYRPAAAQDMVGGDWYDAYPLDRAPCPGGETATLAVTIGDITGHDMRAATLMGQARSMLRQADHDHPDGGPATAVQALESANTALGLDLSGTLVHAHLAPAADGWTLTWTNAGHPAPLLARPGTSCEHLDDHDLLLHPSLHGRHRTQRRLHLPVGATLLLYTDGLVERPGQDIDTGIQRACALLHEGEDWPLEELLETIADRVAGDAPGDDIALLALRVTHPPHPDPA
>NC_021985.1|WP_162473327.1|158867_159011_-|hypothetical-protein
MRRFDLYARMRAGRDSLLRTQRSSPQDEDKAFQELEAVMARLREEQR
>NC_021985.1|WP_043477068.1|158306_158738_-|ATP-binding-protein
MLKTGAALVGDGTDIARARHLAAAFLTRVQAEHGLPVSQRAMDLTQLVVSELVTNARKYAPGPVLLDLAITGDTVEVAVWDACPVLPVARAADAGRVGQHGLEIVMAVARGFEARRESLGKRITVRIALADDPGGAVSGRRPL
>NC_021985.1|WP_106960646.1|157278_158211_+|NADP-dependent-oxidoreductase
MRAVRFHEYGGIEVLRVEEVERPVPGPGQVLVEVRAAGIQPGEAHIRTGALHDRWPAVFPSGQGSDLAGVVVESGPHVRGFAVGDEVVGFTHRRASHAQFVVVDDVHLVFRPAGLDWDVAGALYVAGTTAYATVFAADPGPGDTVVVSGAAGGVGSLAVQLARRHGATVIGLASERNHAWLKEHGVLPVAYGPGVAGRIREACGGRVDAFIDTFGDGYVALAVELGVRPERINTISDWQAAAEVGARTYGEGAAASAVVLGELARLASRGQLEVPIARTYPLEQVRDAFRELERQHTHGKIVLRPQEKSF
>NC_021985.1|WP_020937469.1|167186_167513_-|STAS-domain-containing-protein
MTTPLTLTSGRRPDGTVCLTVAGEIDMSNAGSLAEALDAHAGPVVVDLTGVEYLDSAGLSVLFAHADRLQLLVTPLLEPVLTVSGLTDLATVHALGPDHRPSPPRPCP
>NC_021985.1|WP_106960518.1|172279_172906_+|anti-sigma-factor-antagonist
MPGPRPAPSRSRPPLARSTVSRLRPAFFRSPRTPGRPEEVPAFPRRALAPAADNPGGQQKTRGERPPDKNTPRPVVAEHTGVLVNDTEGTLAISVHPSPAGPVVLRLAGELDHHTGARLGRAVEDLLHSPGPGPAPGIVADLSRLYYCDSTGITTILTAHDRARATGSSFCVAAPSPALAQLFRMTGLDQVLPFHPSVQDAVEALSND
>NC_021985.1|WP_020937471.1|173020_173389_+|hypothetical-protein
MREDAGLHCAQKPLFLINYRRPPTATDGLLSPTKGRSTAGALPGRPPQPPRPPVRPAGPPSALPALPALPALPALPALLLLLLQWADRGPDAAVAVAVVREAAGGGAGVWRRRLRAASGGRA
>NC_021985.1|WP_158506725.1|173501_174116_+|helix-turn-helix-domain-containing-protein
MTHLAVICDWPLLQLGLTQALEAQPDMRITTLASCVDEVALETADVEVILLINLQSRDQVTSREVARLYRQGHAVIVLSASGAPSDAVLCIKAGARGYLSRQTDACELVSAVRAVASGSDYFGASLAGRSIPAPPPHITGRERQILQFVADGATDREIAAKLNIAENTVHTHLERLRRKSGSRRRAELTRFALENGIIEDDLLE
>NC_021985.1|WP_162473328.1|174559_175282_+|hypothetical-protein
MRVAGAATLGAALGVAGTATLRTTLGVAGTATLGAALGIAGTTTLRPALGVTGTATLGAALGVAGTATLRTTLGVAGTATLRTTLGVAGTATLGAALSVARTATLRTTLGVAGTATLGAALSVAGTATLRPALGVTAAATLRTTLGVTAAATLRPTLGVTAAATLRPALGVTAATTLRPALGVTAATTLRPALGVTAATTLRPALGVAPLLGLLVAVVLARLVREQAVCLCTVADVPLSC
>NC_021985.1|WP_158506727.1|175754_175925_-|hypothetical-protein
MWSSALGGTSCARPVRAEETLDLDLDLDLGLVRIGGGRSELPVLRDRVLNISAGRL
>NC_021985.1|WP_020937474.1|176297_176831_-|2'-5'-RNA-ligase-family-protein
MRTVELLLDETAETAVRQAWRRLADAGLPSQARHPSPTNSPHLTLAACPELTAPIRWELAGAAAVLPLPVRFTGLVRFERPTSVLAWALDLDSALAGLHRRVWEAVASDSPPETLNPFHHPTRWSPHITLGRTRRPGAFTDRQIPGLLPAPPLSARLITLRSYDTDTGALEILTPRP
>NC_021985.1|WP_043477077.1|177145_177481_+|hypothetical-protein
MTAIRHLGRKSDVVLALRDADVIAAQLRQALAEASPQERPGLERAAALVESTAAASETRLRARWVRDRLAEAGFSGDITSVAAVKALRQAEPRLSLLAAVQLQKDAVTHPE
>NC_021985.1|WP_106960520.1|177980_178331_-|hypothetical-protein
MGAVACTLCVAPGTRDVGAALAAGRRRLTGARPQGYFLLAAPGAPPRRGDRPPWFLWLRWRRSSARRNGPGWSSGAGAWCVRQVAGSGPRPARSTDGLDRDPAARGLSAGSPAVEA
>NC_021985.1|WP_020937476.1|178592_178952_+|hypothetical-protein
MPKPDELIIDIAALVESGQSSQMSLTVVTGGAVITGRLAPEAMWRQRVREVLTDSAQLSDFSAVFDHPARQAGPPTHLHFHLARILQGPVGIPETGGMYRVAIDDVSAWTVGDFSYFDH

Crispr_ID: NC_021985_2

• CRISPR_ID: NC_021985_2
• CRISPR_location: 169908-170015
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_2

Consensus_repeat	Method
GGGGCGGGGGTGTTGCCCGGCAGC	CRISPRCasFinder

spacers of NC_021985_2

>2.1|169932|60|NC_021985|CRISPRCasFinder
GTGCCGGGCGGGGCGGGGGTGTTGCCCGGCAGCGCACCGGCGGGTGCGGCGCCGGACGGG

CRISPR arrays and Neighbor proteins around NC_021985_2

CRISPR arrays

The CRISPR arrays of NC_021985_2

>merge|NC_021985|2|169908-170015|CRISPRCasFinder
GTGGCGGGTGCGGTGCCGGGCGGGGTGCCGGGCGGGGCGGGGGTGTTGCCCGGCAGCGCACCGGCGGGTGCGGCGCCGGACGGGGTGGCGGGTGCGGTGCCGGGCGGG

>NC_021985|2|2|169908-170015|CRISPRCasFinder
GTGGCGGGTGCGGTGCCGGGCGGG	GTGCCGGGCGGGGCGGGGGTGTTGCCCGGCAGCGCACCGGCGGGTGCGGCGCCGGACGGG
GTGGCGGGTGCGGTGCCGGGCGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_106960520.1|177980_178331_-|hypothetical-protein	unknown	unknown	gnl|CDD|375043
NC_021985.1|WP_020937469.1|167186_167513_-|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NC_021985.1|WP_020937474.1|176297_176831_-|2'-5'-RNA-ligase-family-protein	unknown	unknown	gnl|CDD|379265
NC_021985.1|WP_020937465.1|162864_163818_-|potassium-channel-protein	unknown	unknown	gnl|CDD|223643
NC_021985.1|WP_020937464.1|161708_162806_-|winged-helix-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|377630
NC_021985.1|WP_043477071.1|166125_166944_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|272862
NC_021985.1|WP_106960518.1|172279_172906_+|anti-sigma-factor-antagonist	unknown	unknown	gnl|CDD|132914
NC_021985.1|WP_043477077.1|177145_177481_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020937477.1|179420_179624_-|cold-shock-protein	unknown	unknown	gnl|CDD|224197
NC_021985.1|WP_020937463.1|161343_161556_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_162473327.1|158867_159011_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043477068.1|158306_158738_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_021985.1|WP_078614862.1|159296_161033_-|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NC_021985.1|WP_158506727.1|175754_175925_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020937471.1|173020_173389_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020937476.1|178592_178952_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_158506725.1|173501_174116_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225107
NC_021985.1|WP_043474429.1|164091_164808_-|DUF1345-domain-containing-protein	unknown	unknown	unknown
NC_021985.1|WP_162473328.1|174559_175282_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020937467.1|165020_165425_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_043477068.1|158306_158738_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.50753e-11
NC_021985.1|WP_106960520.1|177980_178331_-|hypothetical-protein	gnl|CDD|375043	pfam17196, DUF5133, Protein of unknown function (DUF5133). This protein of unknown function is part of the Borrelidin synthesis genomic cluster. Borrelidin is a polyketide antibiotic.	0.00160736
NC_021985.1|WP_020937469.1|167186_167513_-|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.43139e-14
NC_021985.1|WP_020937465.1|162864_163818_-|potassium-channel-protein	gnl|CDD|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	6.21914e-32
NC_021985.1|WP_020937464.1|161708_162806_-|winged-helix-DNA-binding-domain-containing-protein	gnl|CDD|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	4.21819e-45
NC_021985.1|WP_043477071.1|166125_166944_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	4.77603e-86
NC_021985.1|WP_106960518.1|172279_172906_+|anti-sigma-factor-antagonist	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.96511e-25
NC_021985.1|WP_158506725.1|173501_174116_+|helix-turn-helix-domain-containing-protein	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.44303e-38
NC_021985.1|WP_020937477.1|179420_179624_-|cold-shock-protein	gnl|CDD|224197	COG1278, CspC, Cold shock proteins [Transcription].	5.77576e-32
NC_021985.1|WP_078614862.1|159296_161033_-|SpoIIE-family-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	8.80932e-30
NC_021985.1|WP_020937474.1|176297_176831_-|2'-5'-RNA-ligase-family-protein	gnl|CDD|379265	pfam13563, 2_5_RNA_ligase2, 2'-5' RNA ligase superfamily. This family contains proteins related to pfam02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.	5.28921e-07

Protein sequences

>NC_021985.1|WP_020937469.1|167186_167513_-|STAS-domain-containing-protein
MTTPLTLTSGRRPDGTVCLTVAGEIDMSNAGSLAEALDAHAGPVVVDLTGVEYLDSAGLSVLFAHADRLQLLVTPLLEPVLTVSGLTDLATVHALGPDHRPSPPRPCP
>NC_021985.1|WP_043477071.1|166125_166944_-|class-I-SAM-dependent-methyltransferase
MWATAVGVARVRALETERADPLFRDPLARAFAAAGGLWPSSPPPPQGDEAARRRRLAVAFSIVIRTKYLDDLLHQACASGIRQVVLLGAGMDSRAFRIDWPEDTRLFEVDTAQPLDFKDQVLRQEQAVPRCRRIPVAVDLREDWPQALAAAGHDPATPTVWIAEGLLIYLPRDAVDLLLSRIGARSAPGSRMGLTLGSRGVIERFGADAAPGSAASLWVSEMPDDPVGWLAGHGWDAETHTLRERAAAYGRPAGTPPSHEEGPGGLVSAVRR
>NC_021985.1|WP_020937467.1|165020_165425_-|hypothetical-protein
MRAGRRFSPLPRYRGVWAAGLTALPALFALSAVTPAAAAVPAHHQQAQPHPRYVQVSNTQTCNPDGLCTITATCPSGTVVTGGGVSETPLISSGVYLMETEPTSSRTWRGTLRNASQFPVQVTVTAVCARIPGV
>NC_021985.1|WP_043474429.1|164091_164808_-|DUF1345-domain-containing-protein
MARTRTQASTRHPRHERRGEARLPAVVATLAAIALYLLLPQRLLIAPRYVLPALECLLLIPLIAINPKRLTRQTKTFRVLSLTLVGVIAISNLVALAILIHELVYAGVKDGRSLLVAALQVWLTNIIVFGLAYWELDRGGPVSRTQAPRSALPLADFRFSQDENDDAVQEVADGASATSDWVPTLVDYLYVSTTNSTAFSPTDTMPLSTRAKAMMSIQSIAALLTSLLVIARAVSILH
>NC_021985.1|WP_020937465.1|162864_163818_-|potassium-channel-protein
MLLAAFALLALLAAGVGGYTLFGFSLPDAVYMTVMTLTTEGFSGADRLTEAGKLFTAALAVVGVALFVAVLGLIGTALVEGRFGPAGRKRRMQHRIDTLRDHFIVCAYGRVGQAVAREFEAEGVPFVVIENKTALEEQLQRERAPYLIGNAASEQVLRRAGIAHARGLVCAVDSDAENVYITLIAHSLNPSLAIVSRASEAASAERLTHAGASSVVSPYITSGRRMALLAVRPHVVDFLEFTRAGSSDVRIEEIRFDTGSRLVGRPLRQACGGALPLLIRRADGTLEPNPDPDTAVQAGDTMIVFGDPGALRPIEDD
>NC_021985.1|WP_020937464.1|161708_162806_-|winged-helix-DNA-binding-domain-containing-protein
MPEYDRVRLRRACAQALAGGVREATAEAVVRRVCALQAQDAMAADLGIRARGADITAPAVRAAYEDERSIVRGWYLRGTLHTVCSEDARPLLALLAPRILAATGRRYHQLGLHEELRRRADHLIRQVLSTHGPLTRAELTGHLTPLGIPPDGQAPFHLIRHAALTGVLCHGPRRAGEATYVLLDDWLPRGGGRREADGDAALAELARRYLAAHAPAGPQDFAVWSGLPLSWARRAWNTLARAAAITADGDLTTLAARAGKREYPPDAPGAPGAPDVRMLPALDNYLLGYRSREACVPAAHEADVWPGGGVIRPTVVADGLVVATWARRDAGRSITVRAFAPLPPGTRAAVDAETEDVSRFCRRSA
>NC_021985.1|WP_020937463.1|161343_161556_-|hypothetical-protein
MIVKKLHESGIRAEHAYAAAFVSIGLSVISWAASLQVEKKGEERADRWGIFVGEWAPTFFGLGLALSTYE
>NC_021985.1|WP_078614862.1|159296_161033_-|SpoIIE-family-protein-phosphatase
MSASADAGMDRFARLVANVLDVPVALVALAEDGRQVFPGMAGAGRPWSVSRQAALADSLCALVVGSGAPLVVSDARTDPRTRSGPVVTHLRAAGYAGMPLTDPHGTVLGALCAVDTRPRRWSEREVQALEDLAAACTAELRLRIVSRQAEEARAETAALLARSELVLRASEVLADTAGVEEVRTQVGELITSDLKPVYVGFSLEPAPRPGRARGPARAHPQAPQVDPDDGAWPTARAVRDKRLVEVHGVDEVRAAYGRHAAARWESLGFASMVCLPLAGTHRTLGALALAWDTEHRPDVAERAVLYAVSGYAAQALERAQFLDDRIDVARRLQEAMLTDLPAVDGLATAALYRPAAAQDMVGGDWYDAYPLDRAPCPGGETATLAVTIGDITGHDMRAATLMGQARSMLRQADHDHPDGGPATAVQALESANTALGLDLSGTLVHAHLAPAADGWTLTWTNAGHPAPLLARPGTSCEHLDDHDLLLHPSLHGRHRTQRRLHLPVGATLLLYTDGLVERPGQDIDTGIQRACALLHEGEDWPLEELLETIADRVAGDAPGDDIALLALRVTHPPHPDPA
>NC_021985.1|WP_162473327.1|158867_159011_-|hypothetical-protein
MRRFDLYARMRAGRDSLLRTQRSSPQDEDKAFQELEAVMARLREEQR
>NC_021985.1|WP_043477068.1|158306_158738_-|ATP-binding-protein
MLKTGAALVGDGTDIARARHLAAAFLTRVQAEHGLPVSQRAMDLTQLVVSELVTNARKYAPGPVLLDLAITGDTVEVAVWDACPVLPVARAADAGRVGQHGLEIVMAVARGFEARRESLGKRITVRIALADDPGGAVSGRRPL
>NC_021985.1|WP_106960518.1|172279_172906_+|anti-sigma-factor-antagonist
MPGPRPAPSRSRPPLARSTVSRLRPAFFRSPRTPGRPEEVPAFPRRALAPAADNPGGQQKTRGERPPDKNTPRPVVAEHTGVLVNDTEGTLAISVHPSPAGPVVLRLAGELDHHTGARLGRAVEDLLHSPGPGPAPGIVADLSRLYYCDSTGITTILTAHDRARATGSSFCVAAPSPALAQLFRMTGLDQVLPFHPSVQDAVEALSND
>NC_021985.1|WP_020937471.1|173020_173389_+|hypothetical-protein
MREDAGLHCAQKPLFLINYRRPPTATDGLLSPTKGRSTAGALPGRPPQPPRPPVRPAGPPSALPALPALPALPALPALLLLLLQWADRGPDAAVAVAVVREAAGGGAGVWRRRLRAASGGRA
>NC_021985.1|WP_158506725.1|173501_174116_+|helix-turn-helix-domain-containing-protein
MTHLAVICDWPLLQLGLTQALEAQPDMRITTLASCVDEVALETADVEVILLINLQSRDQVTSREVARLYRQGHAVIVLSASGAPSDAVLCIKAGARGYLSRQTDACELVSAVRAVASGSDYFGASLAGRSIPAPPPHITGRERQILQFVADGATDREIAAKLNIAENTVHTHLERLRRKSGSRRRAELTRFALENGIIEDDLLE
>NC_021985.1|WP_162473328.1|174559_175282_+|hypothetical-protein
MRVAGAATLGAALGVAGTATLRTTLGVAGTATLGAALGIAGTTTLRPALGVTGTATLGAALGVAGTATLRTTLGVAGTATLRTTLGVAGTATLGAALSVARTATLRTTLGVAGTATLGAALSVAGTATLRPALGVTAAATLRTTLGVTAAATLRPTLGVTAAATLRPALGVTAATTLRPALGVTAATTLRPALGVTAATTLRPALGVAPLLGLLVAVVLARLVREQAVCLCTVADVPLSC
>NC_021985.1|WP_158506727.1|175754_175925_-|hypothetical-protein
MWSSALGGTSCARPVRAEETLDLDLDLDLGLVRIGGGRSELPVLRDRVLNISAGRL
>NC_021985.1|WP_020937474.1|176297_176831_-|2'-5'-RNA-ligase-family-protein
MRTVELLLDETAETAVRQAWRRLADAGLPSQARHPSPTNSPHLTLAACPELTAPIRWELAGAAAVLPLPVRFTGLVRFERPTSVLAWALDLDSALAGLHRRVWEAVASDSPPETLNPFHHPTRWSPHITLGRTRRPGAFTDRQIPGLLPAPPLSARLITLRSYDTDTGALEILTPRP
>NC_021985.1|WP_043477077.1|177145_177481_+|hypothetical-protein
MTAIRHLGRKSDVVLALRDADVIAAQLRQALAEASPQERPGLERAAALVESTAAASETRLRARWVRDRLAEAGFSGDITSVAAVKALRQAEPRLSLLAAVQLQKDAVTHPE
>NC_021985.1|WP_106960520.1|177980_178331_-|hypothetical-protein
MGAVACTLCVAPGTRDVGAALAAGRRRLTGARPQGYFLLAAPGAPPRRGDRPPWFLWLRWRRSSARRNGPGWSSGAGAWCVRQVAGSGPRPARSTDGLDRDPAARGLSAGSPAVEA
>NC_021985.1|WP_020937476.1|178592_178952_+|hypothetical-protein
MPKPDELIIDIAALVESGQSSQMSLTVVTGGAVITGRLAPEAMWRQRVREVLTDSAQLSDFSAVFDHPARQAGPPTHLHFHLARILQGPVGIPETGGMYRVAIDDVSAWTVGDFSYFDH
>NC_021985.1|WP_020937477.1|179420_179624_-|cold-shock-protein
MAAGTVKWFNAEKGFGFIEQDGGGADVFAHYSNIAAQGFRELIEGQKVTFDIAQGQKGLTAENIVLA

Crispr_ID: NC_021985_3

• CRISPR_ID: NC_021985_3
• CRISPR_location: 965561-965679
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_021985_3

Consensus_repeat	Method
TCCTTGCCGGAGCCCTTGCCCCG	CRISPRCasFinder

spacers of NC_021985_3

>3.1|965584|25|NC_021985|CRISPRCasFinder
CTCCGTGCTGTAGTCGTTGTCGTGG
>3.2|965632|25|NC_021985|CRISPRCasFinder
TTCGTTGCCGGAGCCCTGGCCCCGT

CRISPR arrays and Neighbor proteins around NC_021985_3

CRISPR arrays

The CRISPR arrays of NC_021985_3

>merge|NC_021985|3|965561-965679|CRISPRCasFinder
TCGCGTCCGCCGCCCTTGCCGCGCTCCGTGCTGTAGTCGTTGTCGTGGTCCTTGCCGGAGCCCTTGCCCCGTTCGTTGCCGGAGCCCTGGCCCCGTTCGTTGCCGGAGCCCTTGCCCCG

>NC_021985|3|3|965561-965679|CRISPRCasFinder
TCGCGTCCGCCGCCCTTGCCGCG	CTCCGTGCTGTAGTCGTTGTCGTGG
TCCTTGCCGGAGCCCTTGCCCCG	TTCGTTGCCGGAGCCCTGGCCCCGT
TCGTTGCCGGAGCCCTTGCCCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_052352122.1|952917_954285_-|L-seryl-tRNA(Sec)-selenium-transferase	unknown	unknown	gnl|CDD|235278
NC_021985.1|WP_020938095.1|969768_969960_+|putative-ATP-grasp-modified-RiPP	unknown	unknown	gnl|CDD|373048
NC_021985.1|WP_193384524.1|971985_973083_+|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NC_021985.1|WP_020938101.1|975286_975754_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043474700.1|959497_960961_+|glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|236219
NC_021985.1|WP_020938097.1|970995_971892_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NC_021985.1|WP_020938102.1|976327_977578_+|serine-hydrolase	unknown	unknown	gnl|CDD|365903
NC_021985.1|WP_020938093.1|966356_967358_+|hypothetical-protein	unknown	unknown	gnl|CDD|226708
NC_021985.1|WP_020938085.1|956859_957183_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020938086.1|957250_957943_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_021985.1|WP_020938090.1|963136_964090_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NC_021985.1|WP_020938100.1|973595_974945_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|235917
NC_021985.1|WP_020938091.1|964316_964994_-|class-F-sortase	unknown	unknown	gnl|CDD|320678
NC_021985.1|WP_020938099.1|973139_973580_-|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
NC_021985.1|WP_020938089.1|961045_962983_-|collagenase	unknown	unknown	gnl|CDD|366791
NC_021985.1|WP_193384428.1|954806_955838_-|MASE1-domain-containing-protein	unknown	unknown	gnl|CDD|283013
NC_021985.1|WP_020938096.1|969976_970960_+|ATP-grasp-ribosomal-peptide-maturase	unknown	unknown	gnl|CDD|275040
NC_021985.1|WP_020938087.1|958070_959279_-|hypothetical-protein	unknown	unknown	gnl|CDD|227829
NC_021985.1|WP_052352242.1|967553_968447_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020938084.1|955888_956743_-|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|369272

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_052352122.1|952917_954285_-|L-seryl-tRNA(Sec)-selenium-transferase	gnl|CDD|235278	PRK04311, PRK04311, selenocysteine synthase; Provisional.	1.47071e-178
NC_021985.1|WP_193384524.1|971985_973083_+|serine/threonine-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.27383e-40
NC_021985.1|WP_193384428.1|954806_955838_-|MASE1-domain-containing-protein	gnl|CDD|283013	pfam05231, MASE1, MASE1. Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins. This entry also includes members of the 8 transmembrane UhpB type (8TMR-UT) domain family.	1.17354e-36
NC_021985.1|WP_020938095.1|969768_969960_+|putative-ATP-grasp-modified-RiPP	gnl|CDD|373048	pfam14404, Strep_pep, Ribosomally synthesized peptide in Streptomyces species. A ribosomally synthesized peptide related to microviridin and marinostatin, usually in the gene neighborhood of one or more RimK-like ATP-grasp. The gene-context suggests that it is further modified by the ATP-grasp. The peptide is predicted to function in a defensive or developmental role, or as an antibiotic.	4.09144e-31
NC_021985.1|WP_020938097.1|970995_971892_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.24527e-30
NC_021985.1|WP_020938102.1|976327_977578_+|serine-hydrolase	gnl|CDD|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.17649e-52
NC_021985.1|WP_020938093.1|966356_967358_+|hypothetical-protein	gnl|CDD|226708	COG4257, Vgb, Streptogramin lyase [Defense mechanisms].	1.20009e-21
NC_021985.1|WP_020938086.1|957250_957943_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	8.68124e-13
NC_021985.1|WP_020938090.1|963136_964090_-|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.72507e-30
NC_021985.1|WP_020938100.1|973595_974945_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|235917	PRK07046, PRK07046, aminotransferase; Validated.	0
NC_021985.1|WP_020938091.1|964316_964994_-|class-F-sortase	gnl|CDD|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	8.85439e-55
NC_021985.1|WP_020938099.1|973139_973580_-|Lrp/AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.48728e-25
NC_021985.1|WP_020938089.1|961045_962983_-|collagenase	gnl|CDD|366791	pfam01752, Peptidase_M9, Collagenase. This family of enzymes break down collagens.	3.98666e-136
NC_021985.1|WP_020938084.1|955888_956743_-|serine/threonine-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.56203e-44
NC_021985.1|WP_020938096.1|969976_970960_+|ATP-grasp-ribosomal-peptide-maturase	gnl|CDD|275040	TIGR04187, conserved_hypothetical_protein, ATP-grasp ribosomal peptide maturase, SAV_5884 family. Members of this protein family are ATP-grasp ligase family enzymes that regularly occur in a contexts with a methyltransferase and a putative ribosomally translated post-translationally modified peptide precursor. Because of this conserved gene neighborhood and close sequence similarity to ATP-grasp enzymes from microviridin/marinostatin biosynthesis cassettes, this enzyme is suggested also to serve as a peptide maturase.	2.46622e-131
NC_021985.1|WP_020938087.1|958070_959279_-|hypothetical-protein	gnl|CDD|227829	COG5542, COG5542, Predicted integral membrane protein [Function unknown].	2.27504e-06
NC_021985.1|WP_043474700.1|959497_960961_+|glyceraldehyde-3-phosphate-dehydrogenase	gnl|CDD|236219	PRK08289, PRK08289, glyceraldehyde-3-phosphate dehydrogenase; Reviewed.	0

Protein sequences

>NC_021985.1|WP_020938091.1|964316_964994_-|class-F-sortase
MAAAPPSPPPAEPARDERQSGRGGRLTLWGVAIVFLGVSLFGGHHGSRETPAAPRASGPTSSVRSDTRSTEAGDGLPHSVPTRLLIPKISVDAPFAALTLGPTGQLEPPPADNTNLVGWYAKGASPGETGTSIIAGHVDTVTSAAVFANLDQLEPGDRFSVDRADGRTANFEVDDTETFAKDAFPSERVYADADRPEARLITCAGDYDHSVKDYTDNLVVFAHLV
>NC_021985.1|WP_020938090.1|963136_964090_-|LysR-family-transcriptional-regulator
MELELRHLRVLCAIADAGSVGRAATHLGYSQPAVSTQLGRIERHLGEPLFERGASGVRPTPYGAEVVAQARDVLARADAIGHRRPSTAPRRTLRVASTNSPMLSGTVSRVRTRLPDLSLTLTSVYASSRIVELLEEGTVDVAIAADYPGMELRHSAAVRHRGIVTEPTFVALPARHRLRQCAQVQLADLAEDDWFVTPDDGAGWPGVFYDACAAAGFTPAAVHEFLGDQSQLQSMIADGLGVSLVQPTLRPIPHVAVKPLAGSPLWCRYVLAWRPGTVSEDVADTLVQSALAAYRDLVAQAPHLRDWASRTWSIAGA
>NC_021985.1|WP_020938089.1|961045_962983_-|collagenase
MRYRFGLPGRMAGAAAVCVTVAGLLSTPALASPQQHLGTTVRTAGRHAPAPPPAGPATGASERPAAPARRLSPAQLPPRAPASTRSSESAPRGAAKAASCTPADFGGRTGSALVAFVRASTPDCVNTLFTVTGRDAHDVFRQAQMVTVANAFTSTARKYRGDNSGSLEQLVLFLRAGYYVQFNHAADVGAYTSRLTSAVTAGLDTFFARSHTRDVSAANGDILGEAVVLTDSADQQGRYLYVYRRLLDGYDSSYDAVDSMIRAVNDVYTPLWRGNWNPEYVRAVAADPRVIDTLYDFALANTDLLGTGLAFLDSNAGMNVARYLEHPELRDTAQPLTKGLLDATAMTGPTAGLWVAVATQANYYDAANCSSYGVCDLPGKLTEAVLPTVHRCDANITVRAQALTAADLDAACAGVLGQDAYFRSLVKAAGPVPGQYVSTLRLVVFASRADYQTYAGAIFGISTDNGGMTLEGDPSDPANQATSIMYQKDYDDGFTARIWNLNHEYTHFLDGRDDMRGDFGRQISVPDVWWIEGVAEYVSYGYRGLADDQAVQEAGKHTYRLSTLFENTYDNSDVTRTYPWGYLAVRYMAERHPDDVQRMLARFRAGDYTGGYAVYHDGIGTRYDADFDQWLTACASGACARPAKA
>NC_021985.1|WP_043474700.1|959497_960961_+|glyceraldehyde-3-phosphate-dehydrogenase
MTVNAVNDDSFTNWKIREEIAESMIPLIGKLHRERDVTVLLHSRSLVNKSVVSILKTHRFARQIAGAELSVTETMPFLQALTALDLGPSQIDLGMLATLYQADDRGLSVAEFTAEAVAGATGAGKIERRESRDVVLYGFGRIGRLVARLLIEKSGSGNGLRLRAIVVRGGGARAAGDLVKRASLLRRDSIHGQFQGTITVDEDASTIVANGNEIKVIYADDPSHVDYTEYGIRDAILIDNTGKWRDREGLSKHLRPGIEKVVLTAPGKGDVPNIVHGVNHDTVKPDEQILSCASCTTNAIVPPLKAMDDEYGVLRGHVETVHSFTNDQNLLDNYHKSERRGRSAPLNMVITETGAASAVAKALPDLKAKISGSSIRVPVPDVSIAILNLQLARETTREQVHDYLREVSLTSPLKRQIDFTTAPDAVSSDFIGSRHASIVDAGALKVDGDNAILYLWYDNEFGYSCQVVRVVQHVSGVEYPTYPATAV
>NC_021985.1|WP_020938087.1|958070_959279_-|hypothetical-protein
MSTSSVPRPESDAAFRPLRRPSLTHLRRHRVPEGAPAALALFAAVRLAGVAAVLAAGHLTGHSAARSLAHSWDSRWYLHIATHGYGRLIWITPTGGVQADWAFFPFYPGLVRALTTVLPLTPGQAALLVAWAAALVAAYGLYLLGHHLYGHAVATALVGLWAVLPHAVELTIAYTESLFAALAVCSLYCVLKDRWLWAGSLAALAGLSRPTGFAVAAAVCIAAAREVLRRRGRVPATLWAGALIAPLGWFGYVLWVGERTGDLLGGYFKVQSAWDSRFDFGAGTLRFLKALLLHGGGVVYPAALMIVLTCVVLFGLLCLDRAPLVLLVFAGVLVLLVACGSGSFSSKPRFLLPVFPLLIPPARALARTWRVRPARALLVVGALAVMSVLYGAYVVVVAHSPL
>NC_021985.1|WP_020938086.1|957250_957943_-|alpha/beta-hydrolase
MRLHTHEWGTGDRVAVLVHGIMSDHRTWRRVAPVLADKGYRVVGVDLRGHGASGRGPYGAEIWAGDLVETLPGKPELAIGHSLGAMALVLAAERLSPARAVYCDPAWEPAAGLASAGALFADFKTASRAMITHFNPRWEEADVDVELATLALWDPATAHALADVYAVSRTPARPVVPSLVVRAGSSALVPPALAERLTRAGFEVRTVTTAGHTLYRDDFDGFMAALDGWV
>NC_021985.1|WP_020938085.1|956859_957183_-|hypothetical-protein
MTTYVITVPGTFTAGVGADTREVLGRALRPADPHSTRMGSTEDLDVLSVNEDNTFTLRLTVDADTGPHAEQEARRLADSALRSAGLDENTAPLGPAVITGIDSEVGG
>NC_021985.1|WP_020938084.1|955888_956743_-|serine/threonine-protein-phosphatase
MPRKRTTDDGDELLARLGSLTAQARERAEQQRTQVELAIALQRGMLPRDLPTASGLHLAVRYAPATYGLNVGGDWYDAFTMPDGRIGLSIGDVQGHNIEAAAFMGQVRAGLRALASVTSEPGDLLARTNDLLLSLGSDLFATCTFMRLDPVTGVLESARAGHIPFVWATAEGQSGVVDDEGGPPLGIQRGMEYPVTRHHLTTGGVFVLLTDGVVEGPSLNIEDGLEHVVRLAGIAAVAGLEAHALAGAVIKGAESVGHEDDAAVLVVGLDGPRVTGPDGAAVQP
>NC_021985.1|WP_193384428.1|954806_955838_-|MASE1-domain-containing-protein
MAAVAGFMEVRGPGGYAVQVLAVAACYYGAGRLGLLRRLVVEGAVVTPLWPPTGVAVAALLVFGLAAWPGITIGAFFTVLTLSPPDVGMMGFLFGNTVAPLCAVLLLRRSGFRPELSRLRDGLALVFLGALSAMMISASVGVGLLLATDKLPVHNFWPVWLAWWVGDAMGVLIVTPIALLLYKSRRPLPLGRWKEATALAAVACAVVPLAAYSSISLLFLVYPLLIWAALRFQLAGSMLCALLTSVLATVAATDGDGAFAGLSRIEVMAKLQAFNGAMALTALLLSAVITEQRHTRRSVERACQELVEVLEHLTAGEVPPTPRSASDPEDRPRPGHTPGPGPG
>NC_021985.1|WP_052352122.1|952917_954285_-|L-seryl-tRNA(Sec)-selenium-transferase
MARRQDPAPQPQPQPQPQPQPGADARRRIPRTDVLLRDSRLAAAADRLGERLVKDAIRRAQREAREGAVPPERVADRAAALLPAGCGGLRPVVNATGVLLHTNLGRAPLSAAARQAVAEAAGPTDVELDLALGVRARRGRSVLAALSGRVPAAGAAHVVNNGAAALVLAATALAAGREIVISRGEMVEIGDGFRLPDLLVSTGARLREVGTTNRTTAADYAAAIGPDTGFVLKVHPSNFLVTGFTRAAETGELAGLGVPVVVDIGSGLLAPHPALPSEPDADTQLRAGAALVTASGDKLLGGPQCGLLLGREDLVTTLARHPLARALRVDKLTLAALEATLTGPPTPTETALTADPAGLTARAERLAAALRSDGTDVRAVGSTATVGGGGAPGVTLPSAALSLPEPYAAALRAGPDPVVGRLEAGRCLLDLRTVPPEDDERLAGAVRAARPAAGR
>NC_021985.1|WP_020938093.1|966356_967358_+|hypothetical-protein
MPAAAPPDGGPRRPLTALLAALLGIAAVAAPARADAGPVTVFPITTTPGTLPAGITAGPDGALWFTGSGVGRIGRITTGGAVTDFPTSRPDSFPFGITAGPDRALWFTEGRGNRIGRITTAGRVTEFPVPTAGAFPAGIAAGPDGALWFTEQDGDRIGRITTAGRVTEFALPTADASPSAIAAGADGALWFTEPAGRRIGRISVTGRITEFPLPGGADLPGDIVSGPGGMWFTVSGPDAVGRIDSAGRVTRFALPGADSGASGITLGPDGHVWYADPAGRIGRVGPDGTVTAFVVPGGEEGVPPFRLTAGPGRTVWFTQLFGNAVGRVSSPAA
>NC_021985.1|WP_052352242.1|967553_968447_+|hypothetical-protein
MWERFEPVHDLVYFAPEARRAADGLGMRGFWMGYFALRAAPLGAVSPSVVTSGFYVFHPARVARALPDAWSYAAPGQVLAARSEAMEAAMTRLFGAESVESAALAEAADLAWEAAAGADTAGRVLAGANQALERPERPAARLWQALTTLREHRGDGHVAVLVGQGLGPVEAMVLKAAAGESDGPFLRETRKWPQEDWTAAGTALRERGLLTADGALTPAGEAERALVERRTDEAAGRPWAALGAERTERLAGLLEPLARTVLGSGLLPPGNPVGLTGRLLAGSRSGIRFMKPVRQTG
>NC_021985.1|WP_020938095.1|969768_969960_+|putative-ATP-grasp-modified-RiPP
MQPFTLNYARPAVQLDVTTPYAYDSGLQLNVLPDGRIAATDHATLRALGTTTSTAGSKTHFDD
>NC_021985.1|WP_020938096.1|969976_970960_+|ATP-grasp-ribosomal-peptide-maturase
MTVLILTSEEDVTADMVVLRLGEAGVPVVRLDPADLTSGVALSGEYVQGSYGGHLSVGGRLVGMSGLRSVWVRRPGAAAARAAQPSAWLTEEASQALYGMLRCTDARWMNDPDAARRARHKPWQLRLAQHSGLAVPATLITTFPQAAREFAERFPDLVVKPVSGAHPQEPPRAVPTSRVAPDADFSAVAYGPTLLQRRVPKRADIRLTAVGDRLLAARKPADPDAHPDDVDVRFAPSVSPWLPAEVPPRVAEAVLRYLREAGLAYGAFDFAEDADGIWWFLECNQSGQFGFVEMDTGLPIAEAIARWLAGYGERVTPCADGDRDRAS
>NC_021985.1|WP_020938097.1|970995_971892_+|Gfo/Idh/MocA-family-oxidoreductase
MRIGLLGTGPWARAAYAPALAGHPGLHFAGVWGRRPEAAGSLAEEYGVRAYEDVDALLADVDAVAVALPPAVQAQMAGRAARAGRHLLLDKPLALGVAEARGVAEAAERAGVASVVFFTTRFQKEPEAWIDEQAAVAGWFTARAQWLGAVFTADNPFAASPWRREKGALWDVGPHALSVLLPVLGDVRQVLAAAHGPADTVHLVLDHATGASSTLTLSLTAPPAAAGADLELRGDSGVALLPRSSEGAVPALARAADALLTAARTGRPHVCDAGFGLRVTEILAAAEDRLAGAPADQG
>NC_021985.1|WP_193384524.1|971985_973083_+|serine/threonine-protein-phosphatase
MHGRSSPRNQGERGWLRGAPPPRWVRVLPVLLLVGVTLGSLVTPHASDLGFLLGAIPPLAVLSYGPLATAVLGVLVVVALHLPNTHLNRPGNTDLLTIVFVALLSVFVSYVRSRRDAQLDTERAIGEAVQRAVVPPLPERVGRVGCAGFYRAAQDGTLVGGDFFDVREGPHGVRAVMGDVRGHGLTAVATVVSLLGAFREAVLDQPDLEAVAARMDRRLAVDSAGVRHGELFATALLLEFTADTRAVRVVGCGHPAPVLLRAGRAREVTVSVAPPLGLGLVGMDPPKEVTVPLGPGDRLVLASDGVWEARNAAGSFYPLAERLDRLSDTPSGELADAVWEDIAQLGHDVRDDATLLVLTPEPPPA
>NC_021985.1|WP_020938099.1|973139_973580_-|Lrp/AsnC-family-transcriptional-regulator
MDETDKAILRELQTDGRIAYADLGPRVGLSASAARQRLQRLLDSRAVQVVGVTDPMAMGGQAMALLGIGVDGDPRAVADALAARPEVVYSVLTSGGFDLFAEVVAPGPKDLLDFVNDAVRPLDGVREIQTFPYFGIHTHRFLWDVG
>NC_021985.1|WP_020938100.1|973595_974945_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MDRTRLHSLLARESAEAERRNPRSREAYARADHLFGRVPMTWMNKTAGAFPRYLAGARGARITDVDGHEYIDFCLGDTGAMAGHSPAPVTEAADRRFAGLGGATAMLPTEDAEWVGAELTRRFGLARWSFALTATDANRWAIRLARAVTGRPKILVNSYSYHGSVDESLIVVGPDGRGTARPGNVGAPCDVTLTSRVAEFNDLEGLERELAHGDVAAVLMEPALTNIGIVLPEPGYLAGVRELTRRHGTLLINDETHTFSAGPGGCTAAWDLEPDLLTIGKAIGGGIPAGAYGLSADLAERLLGRADLDLVDMGGVGGTLAGNALSVAAMRATLEQVLTDEAFAHMTKLSERFEAGVVAGVEAHRLPWSVSRLGARTEYRFTSPAPRTGTESAAAADPELEDFLHLYLANRGILLTPFHNMALMCPDTTEQDVDTHTEVFAAALSELAG
>NC_021985.1|WP_020938101.1|975286_975754_+|hypothetical-protein
MTNTMWMRGVEWLAASAADPRACKWEWDHGEGIALLEAGRFWDVLSVPERLGLLTLDLLWRPGLPVPGPTLVDTKAGRVGFLLPPDPSAAWVGAGLRYATKGSWVSVPPPYRPARSLEWLIPPDGTGALHAPGTLEEALREANGTLAVLAPLCGR
>NC_021985.1|WP_020938102.1|976327_977578_+|serine-hydrolase
MSLSSARRRRGAALAVVVGTLAVPLTGAPAGAVPPTVPAVLAAGSPSPTPTGPDVRAITPDVARQLDAAVQKVMREAKVPGVTVGLWTPDRGSYVGSFGVADKSDGRAMTPDLYMRIGSETKTFTVTALLQLVDQGKVGLDDPIGKYVDGVPNGDTITLRELAGMRSGLFNYSEDEGFFKALTSDPTRTFTPQQLLAYSFKHPVMFRPGEKFFYSNTNLILLGLVVEKETGQPLGHYIQRNILDPAGMTHTLFPAGAEFPAPHAQGYTNQTADGRIADTAGWNPSWGWAAGAMISRQDDLRVWARTVATGRFPDGSWMVSPATQRQRLITPPTPIPGVGYGLGIFDVQGWIGHNGSLPGYESLTVYLPSARATLVVLLNTDIDHGGQEPSTLFGEAVTRIVTPAHVFDLPAEPAAR

Crispr_ID: NC_021985_4

• CRISPR_ID: NC_021985_4
• CRISPR_location: 975946-976035
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_4

Consensus_repeat	Method
ACACGGGCCACCCCCGAGCCGCCGTGAAC	CRISPRCasFinder

spacers of NC_021985_4

>4.1|975975|32|NC_021985|CRISPRCasFinder
AGGGCCCGACCACCACCTCTCCCCTCCGACGC

CRISPR arrays and Neighbor proteins around NC_021985_4

CRISPR arrays

The CRISPR arrays of NC_021985_4

>merge|NC_021985|4|975946-976035|CRISPRCasFinder
ACACGGGCCACCCCCGAGCCGCCGTGAACAGGGCCCGACCACCACCTCTCCCCTCCGACGCACACGGGCCACCCCCGAGCCGCCGTGAAC

>NC_021985|4|4|975946-976035|CRISPRCasFinder
ACACGGGCCACCCCCGAGCCGCCGTGAAC	AGGGCCCGACCACCACCTCTCCCCTCCGACGC
ACACGGGCCACCCCCGAGCCGCCGTGAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020938102.1|976327_977578_+|serine-hydrolase	unknown	unknown	gnl|CDD|365903
NC_021985.1|WP_158506743.1|983556_983703_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_193384524.1|971985_973083_+|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NC_021985.1|WP_020938097.1|970995_971892_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NC_021985.1|WP_020938101.1|975286_975754_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043474709.1|979528_980374_-|helix-turn-helix-domain-containing-protein	unknown	unknown	unknown
NC_021985.1|WP_020938103.1|977807_979316_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379258
NC_021985.1|WP_020938096.1|969976_970960_+|ATP-grasp-ribosomal-peptide-maturase	unknown	unknown	gnl|CDD|275040
NC_021985.1|WP_020938109.1|986057_986642_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_148305721.1|986721_986982_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020938092.1|965106_965829_-|hypothetical-protein	unknown	unknown	gnl|CDD|237171
NC_021985.1|WP_020938100.1|973595_974945_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|235917
NC_021985.1|WP_020938107.1|983881_984268_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020938099.1|973139_973580_-|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
NC_021985.1|WP_020938108.1|984270_986061_+|hypothetical-protein	unknown	unknown	gnl|CDD|283837
NC_021985.1|WP_020938093.1|966356_967358_+|hypothetical-protein	unknown	unknown	gnl|CDD|226708
NC_021985.1|WP_148305719.1|980595_980859_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_148305720.1|981236_981710_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_052352242.1|967553_968447_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020938095.1|969768_969960_+|putative-ATP-grasp-modified-RiPP	unknown	unknown	gnl|CDD|373048

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020938092.1|965106_965829_-|hypothetical-protein	gnl|CDD|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	2.38137e-07
NC_021985.1|WP_020938100.1|973595_974945_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|235917	PRK07046, PRK07046, aminotransferase; Validated.	0
NC_021985.1|WP_193384524.1|971985_973083_+|serine/threonine-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.27383e-40
NC_021985.1|WP_020938099.1|973139_973580_-|Lrp/AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.48728e-25
NC_021985.1|WP_020938095.1|969768_969960_+|putative-ATP-grasp-modified-RiPP	gnl|CDD|373048	pfam14404, Strep_pep, Ribosomally synthesized peptide in Streptomyces species. A ribosomally synthesized peptide related to microviridin and marinostatin, usually in the gene neighborhood of one or more RimK-like ATP-grasp. The gene-context suggests that it is further modified by the ATP-grasp. The peptide is predicted to function in a defensive or developmental role, or as an antibiotic.	4.09144e-31
NC_021985.1|WP_020938097.1|970995_971892_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.24527e-30
NC_021985.1|WP_020938102.1|976327_977578_+|serine-hydrolase	gnl|CDD|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.17649e-52
NC_021985.1|WP_020938103.1|977807_979316_-|helix-turn-helix-domain-containing-protein	gnl|CDD|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	8.24232e-08
NC_021985.1|WP_020938096.1|969976_970960_+|ATP-grasp-ribosomal-peptide-maturase	gnl|CDD|275040	TIGR04187, conserved_hypothetical_protein, ATP-grasp ribosomal peptide maturase, SAV_5884 family. Members of this protein family are ATP-grasp ligase family enzymes that regularly occur in a contexts with a methyltransferase and a putative ribosomally translated post-translationally modified peptide precursor. Because of this conserved gene neighborhood and close sequence similarity to ATP-grasp enzymes from microviridin/marinostatin biosynthesis cassettes, this enzyme is suggested also to serve as a peptide maturase.	2.46622e-131
NC_021985.1|WP_020938108.1|984270_986061_+|hypothetical-protein	gnl|CDD|283837	pfam06259, Abhydrolase_8, Alpha/beta hydrolase. Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile.	1.65742e-28
NC_021985.1|WP_020938093.1|966356_967358_+|hypothetical-protein	gnl|CDD|226708	COG4257, Vgb, Streptogramin lyase [Defense mechanisms].	1.20009e-21

Protein sequences

>NC_021985.1|WP_020938101.1|975286_975754_+|hypothetical-protein
MTNTMWMRGVEWLAASAADPRACKWEWDHGEGIALLEAGRFWDVLSVPERLGLLTLDLLWRPGLPVPGPTLVDTKAGRVGFLLPPDPSAAWVGAGLRYATKGSWVSVPPPYRPARSLEWLIPPDGTGALHAPGTLEEALREANGTLAVLAPLCGR
>NC_021985.1|WP_020938100.1|973595_974945_-|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MDRTRLHSLLARESAEAERRNPRSREAYARADHLFGRVPMTWMNKTAGAFPRYLAGARGARITDVDGHEYIDFCLGDTGAMAGHSPAPVTEAADRRFAGLGGATAMLPTEDAEWVGAELTRRFGLARWSFALTATDANRWAIRLARAVTGRPKILVNSYSYHGSVDESLIVVGPDGRGTARPGNVGAPCDVTLTSRVAEFNDLEGLERELAHGDVAAVLMEPALTNIGIVLPEPGYLAGVRELTRRHGTLLINDETHTFSAGPGGCTAAWDLEPDLLTIGKAIGGGIPAGAYGLSADLAERLLGRADLDLVDMGGVGGTLAGNALSVAAMRATLEQVLTDEAFAHMTKLSERFEAGVVAGVEAHRLPWSVSRLGARTEYRFTSPAPRTGTESAAAADPELEDFLHLYLANRGILLTPFHNMALMCPDTTEQDVDTHTEVFAAALSELAG
>NC_021985.1|WP_020938099.1|973139_973580_-|Lrp/AsnC-family-transcriptional-regulator
MDETDKAILRELQTDGRIAYADLGPRVGLSASAARQRLQRLLDSRAVQVVGVTDPMAMGGQAMALLGIGVDGDPRAVADALAARPEVVYSVLTSGGFDLFAEVVAPGPKDLLDFVNDAVRPLDGVREIQTFPYFGIHTHRFLWDVG
>NC_021985.1|WP_193384524.1|971985_973083_+|serine/threonine-protein-phosphatase
MHGRSSPRNQGERGWLRGAPPPRWVRVLPVLLLVGVTLGSLVTPHASDLGFLLGAIPPLAVLSYGPLATAVLGVLVVVALHLPNTHLNRPGNTDLLTIVFVALLSVFVSYVRSRRDAQLDTERAIGEAVQRAVVPPLPERVGRVGCAGFYRAAQDGTLVGGDFFDVREGPHGVRAVMGDVRGHGLTAVATVVSLLGAFREAVLDQPDLEAVAARMDRRLAVDSAGVRHGELFATALLLEFTADTRAVRVVGCGHPAPVLLRAGRAREVTVSVAPPLGLGLVGMDPPKEVTVPLGPGDRLVLASDGVWEARNAAGSFYPLAERLDRLSDTPSGELADAVWEDIAQLGHDVRDDATLLVLTPEPPPA
>NC_021985.1|WP_020938097.1|970995_971892_+|Gfo/Idh/MocA-family-oxidoreductase
MRIGLLGTGPWARAAYAPALAGHPGLHFAGVWGRRPEAAGSLAEEYGVRAYEDVDALLADVDAVAVALPPAVQAQMAGRAARAGRHLLLDKPLALGVAEARGVAEAAERAGVASVVFFTTRFQKEPEAWIDEQAAVAGWFTARAQWLGAVFTADNPFAASPWRREKGALWDVGPHALSVLLPVLGDVRQVLAAAHGPADTVHLVLDHATGASSTLTLSLTAPPAAAGADLELRGDSGVALLPRSSEGAVPALARAADALLTAARTGRPHVCDAGFGLRVTEILAAAEDRLAGAPADQG
>NC_021985.1|WP_020938096.1|969976_970960_+|ATP-grasp-ribosomal-peptide-maturase
MTVLILTSEEDVTADMVVLRLGEAGVPVVRLDPADLTSGVALSGEYVQGSYGGHLSVGGRLVGMSGLRSVWVRRPGAAAARAAQPSAWLTEEASQALYGMLRCTDARWMNDPDAARRARHKPWQLRLAQHSGLAVPATLITTFPQAAREFAERFPDLVVKPVSGAHPQEPPRAVPTSRVAPDADFSAVAYGPTLLQRRVPKRADIRLTAVGDRLLAARKPADPDAHPDDVDVRFAPSVSPWLPAEVPPRVAEAVLRYLREAGLAYGAFDFAEDADGIWWFLECNQSGQFGFVEMDTGLPIAEAIARWLAGYGERVTPCADGDRDRAS
>NC_021985.1|WP_020938095.1|969768_969960_+|putative-ATP-grasp-modified-RiPP
MQPFTLNYARPAVQLDVTTPYAYDSGLQLNVLPDGRIAATDHATLRALGTTTSTAGSKTHFDD
>NC_021985.1|WP_052352242.1|967553_968447_+|hypothetical-protein
MWERFEPVHDLVYFAPEARRAADGLGMRGFWMGYFALRAAPLGAVSPSVVTSGFYVFHPARVARALPDAWSYAAPGQVLAARSEAMEAAMTRLFGAESVESAALAEAADLAWEAAAGADTAGRVLAGANQALERPERPAARLWQALTTLREHRGDGHVAVLVGQGLGPVEAMVLKAAAGESDGPFLRETRKWPQEDWTAAGTALRERGLLTADGALTPAGEAERALVERRTDEAAGRPWAALGAERTERLAGLLEPLARTVLGSGLLPPGNPVGLTGRLLAGSRSGIRFMKPVRQTG
>NC_021985.1|WP_020938093.1|966356_967358_+|hypothetical-protein
MPAAAPPDGGPRRPLTALLAALLGIAAVAAPARADAGPVTVFPITTTPGTLPAGITAGPDGALWFTGSGVGRIGRITTGGAVTDFPTSRPDSFPFGITAGPDRALWFTEGRGNRIGRITTAGRVTEFPVPTAGAFPAGIAAGPDGALWFTEQDGDRIGRITTAGRVTEFALPTADASPSAIAAGADGALWFTEPAGRRIGRISVTGRITEFPLPGGADLPGDIVSGPGGMWFTVSGPDAVGRIDSAGRVTRFALPGADSGASGITLGPDGHVWYADPAGRIGRVGPDGTVTAFVVPGGEEGVPPFRLTAGPGRTVWFTQLFGNAVGRVSSPAA
>NC_021985.1|WP_020938092.1|965106_965829_-|hypothetical-protein
MRSARIILATAAATAALSFSAPGAAFAVPAGDDWGRDDSSYSSDHDSDSGRGKGSGNERGQGSGNERGKGSGKDHDNDYSTERGKGGGRDEPRGGMHTGGGALAAVRGDDWGSGGDDSRFDPDTYRDKDQGGGKESGGGKESGGGRDSGGGGKESGGGRNSGGGGKESGGGRDSGGGRDSGGGKDDWGGGDDQEKPHGGMHTGGGGLAQPGVTAGGLAVLAVGATGLYALRRKKAVAPAS
>NC_021985.1|WP_020938102.1|976327_977578_+|serine-hydrolase
MSLSSARRRRGAALAVVVGTLAVPLTGAPAGAVPPTVPAVLAAGSPSPTPTGPDVRAITPDVARQLDAAVQKVMREAKVPGVTVGLWTPDRGSYVGSFGVADKSDGRAMTPDLYMRIGSETKTFTVTALLQLVDQGKVGLDDPIGKYVDGVPNGDTITLRELAGMRSGLFNYSEDEGFFKALTSDPTRTFTPQQLLAYSFKHPVMFRPGEKFFYSNTNLILLGLVVEKETGQPLGHYIQRNILDPAGMTHTLFPAGAEFPAPHAQGYTNQTADGRIADTAGWNPSWGWAAGAMISRQDDLRVWARTVATGRFPDGSWMVSPATQRQRLITPPTPIPGVGYGLGIFDVQGWIGHNGSLPGYESLTVYLPSARATLVVLLNTDIDHGGQEPSTLFGEAVTRIVTPAHVFDLPAEPAAR
>NC_021985.1|WP_020938103.1|977807_979316_-|helix-turn-helix-domain-containing-protein
MGDVAGRADEAPDTRRPQDTDGAWAAQLLDHLRPAGREPRRVVGWLGPAVGAVVCLRDARGGLLAGEPLALDETVLADLVTGRISAAALEDGGRHVRMVGIPHPQQGPAAGAVLAVSRPEPFDRRAAEIVNRTASVLELLLRERELTEAGRRLRRATADLRLAILQLLMVEDTVSARRVAAGLWPGLLEADAARVYVLEGSPADRDRLAEDCADVTGGEALVVRCPAMDGHVIVVTPRPAAGERLRSLVDGRPGVFLGGSLRQRLARTATAYAQAISALAVARFRPDQTAVFAERTRPARLMEPAALRAWSAGVLRPLDRLPHHIRAELLATTRLGLEFTAVNAAKVLGVSRNTVRARMDRVETLLGTDFSDLSTRAAAHLALNTEAAREPHDSDEPPPPAPARLGDLLTSAALRTWADDLLGRLDADGRDLRGTLCAWLAADSNAERTARDLGVHAQTVREHVRAAEPVLERQLLAMGSDLYEVVLAHLSTGALAVPALGR
>NC_021985.1|WP_043474709.1|979528_980374_-|helix-turn-helix-domain-containing-protein
MDDRPRDALSAAQRFTSELGRLRTTAGRPRINTIAARAQCSQSTVCDALNGRRLPGEAICRRVVEALGGEWGPKWLELWRAARIELDTLKRRSAEAPVDALRPEMVRYPDPPSFYGAAADRIRRARREIRLTYVRLHPPNHWGAAEVTEYYSTVLQWARDHSGEGASVRRIIGVPERDGTPRPDYLRWLHEHHAEVRDIYAYEARVMPWTSSCTWHNTGLMDDSVTFLAFSGVGRQQLTGFSVEGADFLAYFADSFDQAWGALEPLDTYVARHCGQFPVPR
>NC_021985.1|WP_148305719.1|980595_980859_+|hypothetical-protein
MPIDLRTSLRHHYMTFLAVLVTGIVLITAVNGITPSTQLYLDCLLGVGGLLAGYVLAPPDPSRPGDPAQPSDAARRPGRTGDASPQC
>NC_021985.1|WP_148305720.1|981236_981710_-|hypothetical-protein
MNSRSEQDTTDDSDVPRPKWTEEIDLQTVDAAGLVRHVTICLSDPSTALIALLDAHSRIEFSGTDYLDCLSQARRQLERDGRLLCCQGARPNVHPSGQLRQFTNGRQAYVRHSERQGEGPEIVDIFAPAPPGDVVNLDDQRAALISSWNARHPGNQI
>NC_021985.1|WP_158506743.1|983556_983703_-|hypothetical-protein
MRGGPSAIAMGRLVRDHVVARDRIDGIIADLRRSWETLDEVNRTARDA
>NC_021985.1|WP_020938107.1|983881_984268_+|hypothetical-protein
MQLNQVPADIGGSSSGIGGGSGTGRLVHTHGPWTRAATVATDLHTSTVKSKADLSLAHDDMAGSLGGLASLATLKAVLASWEERLGSVRDECSTLGPKLHQVAVDMGEADHSVSAKAAAVHVSGSGRG
>NC_021985.1|WP_020938108.1|984270_986061_+|hypothetical-protein
MASTLTWQQLKDLKPETLSHAADAWGAVSRHADSARERIEGRMSGPLDKTQESEAAQAAIKRLKRLEDNYHYIHAESGLIRGTLDGLAAELTAQRKVLTQALDDAAALGYTVDDNGGVSYPADGKNEQTGEGYPGGTVYGEDGHFAPGSAAPSSGKHPLYQPGLGGADGKVKVPNPHYAKAREIANRISFAVLRARGADDRYSGALAELKAAPGLTVGTKTWADIASDVDSVGASALPYIKEKLPLDKTPAERKDWWDHLTADEREEYVTAFPGLIGSLDGIPATARDDANRENLKFLIAKLEGRHDDLSKAQLDGMEGIQAKLDAGSNPPMFLLGIGDEGNGRAIVSYGNPDTAKNVSAYVPGLGTALDGDFADDTVRRAFQTAKDARKYDHSTASIVWLGYDAPGFTEVASTSNADAGAPEYRSFMEGIQATNMHKDPHVTAIGHSYGSLVVGTAARQHGGIPGADDIVLLGSPGTGAQRADELNVGKGHVFSASAGNDPVSWLPGKESFLGPVQAVDSYMDEQRWFGRDPVSREFGAVRIESGDGPLPLYLSNEGPTPAHSGYFDPDRNPSAANNIAKIVAGRSDIVTTEDPR
>NC_021985.1|WP_020938109.1|986057_986642_+|hypothetical-protein
MKKIIAHLAGIALGIAATTGCSGSDGSVKGNSKVDMQEAAEKADALVYRTFRAVRPPLDWTHDASDHGSCGGSDEYGDVTRRAIVMTKVSDERRGALLGVIERYWKKSGLKITKVIPDKEFPEMYAETGDGLLRTGLVVGGEGQFFLDVQTACVRTSEVKAPATQTRGRSYYGKDVPRPNVTDPFWSSRKPISH
>NC_021985.1|WP_148305721.1|986721_986982_-|hypothetical-protein
MRNGALDQRVAAAPEPGPTTLSLTRPVLIALVTGIVQVHLGLLFFLAVREWRRRPQEGAEAEPPKLLGGIGSMSAPKIFDFGLAPA

Crispr_ID: NC_021985_5

• CRISPR_ID: NC_021985_5
• CRISPR_location: 1899630-1899724
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_5

Consensus_repeat	Method
GGAACGGCATCGCTCTCCTGCAC	CRISPRCasFinder

spacers of NC_021985_5

>5.1|1899653|49|NC_021985|CRISPRCasFinder
GGGCTCGGCCTGCGGAACGGCATCGCCCTGCTGCACGGGCTCGGCCTGG

CRISPR arrays and Neighbor proteins around NC_021985_5

CRISPR arrays

The CRISPR arrays of NC_021985_5

>merge|NC_021985|5|1899630-1899724|CRISPRCasFinder
GGAACGGCATCGCTCTCCTGCACGGGCTCGGCCTGCGGAACGGCATCGCCCTGCTGCACGGGCTCGGCCTGGGGAACGGCATTGCTCTCCTGCAC

>NC_021985|5|5|1899630-1899724|CRISPRCasFinder
GGAACGGCATCGCTCTCCTGCAC	GGGCTCGGCCTGCGGAACGGCATCGCCCTGCTGCACGGGCTCGGCCTGG
GGAACGGCATTGCTCTCCTGCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020938913.1|1908746_1909241_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
NC_021985.1|WP_043475020.1|1907782_1908202_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020938896.1|1888274_1889372_-|chorismate-binding-protein	unknown	unknown	gnl|CDD|130883
NC_021985.1|WP_020938894.1|1886550_1887375_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_021985.1|WP_020938902.1|1895421_1896651_-|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl|CDD|381169
NC_021985.1|WP_020938904.1|1901389_1902616_-|precorrin-6y-C5,15-methyltransferase-(decarboxylating)-subunit-CbiE	unknown	unknown	gnl|CDD|381171
NC_021985.1|WP_020938909.1|1906701_1907352_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|319829
NC_021985.1|WP_020938895.1|1887456_1888278_-|aminodeoxychorismate-lyase	unknown	unknown	gnl|CDD|238800
NC_021985.1|WP_020938910.1|1907421_1907781_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020938908.1|1905256_1906291_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|236863
NC_021985.1|WP_106960551.1|1890458_1891724_-|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl|CDD|366736
NC_021985.1|WP_020938905.1|1902749_1903385_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379112
NC_021985.1|WP_020938912.1|1908191_1908689_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_021985.1|WP_020938899.1|1891772_1891949_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020938906.1|1903612_1904446_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270315
NC_021985.1|WP_020938897.1|1890081_1890378_-|zf-TFIIB-domain-containing-protein	unknown	unknown	gnl|CDD|379195
NC_021985.1|WP_020938901.1|1894529_1895348_-|RNA-methyltransferase	unknown	unknown	gnl|CDD|223640
NC_021985.1|WP_043475015.1|1892553_1893942_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NC_021985.1|WP_020938907.1|1904519_1905260_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224922
NC_021985.1|WP_020938893.1|1885946_1886468_+|DsbA-family-protein	unknown	unknown	gnl|CDD|376526

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020938896.1|1888274_1889372_-|chorismate-binding-protein	gnl|CDD|130883	TIGR01824, Anthranilate_synthase_component_I-like_protein, aminodeoxychorismate synthase, component I, clade 2. This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.	6.45442e-119
NC_021985.1|WP_020938894.1|1886550_1887375_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.78845e-12
NC_021985.1|WP_020938902.1|1895421_1896651_-|uroporphyrinogen-III-C-methyltransferase	gnl|CDD|381169	cd11642, SUMT, Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT). SUMT is an enzyme of the cobalamin and siroheme biosynthetic pathway. It catalyzes the first of three steps leading to the formation of siroheme from uroporphyrinogen III; it transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. Precorrin-2 is also a precursor for the biosynthesis of vitamin B12, coenzyme F430, siroheme and heme d1. This family includes proteins in which the SUMT domain is fused to other functional domains, such as to a uroporphyrinogen-III synthase domain to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase, or to a dual function dehydrogenase-chelatase domain, as in the case of the multifunctional S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase/dehydrogenase/ferrochelatase CysG, which catalyzes all three steps that transform uroporphyrinogen III into siroheme.	1.85319e-107
NC_021985.1|WP_020938904.1|1901389_1902616_-|precorrin-6y-C5,15-methyltransferase-(decarboxylating)-subunit-CbiE	gnl|CDD|381171	cd11644, Precorrin-6Y-MT, Precorrin-6Y methyltransferase (also named CbiE). CbiE (precorrin-6Y methyltransferase, also known as cobalt-precorrin-7 C(5)-methyltransferase, also known as cobalt-precorrin-6Y C(5)-methyltransferase) catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8. It participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways in bacteria. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. CbiE functions in the anaerobic pathway, it is a subunit of precorrin-6Y C5,15-methyltransferase, a bifunctional enzyme: cobalt-precorrin-7 C(5)-methyltransferase (CbiE)/cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) (CbiT), that catalyzes two methylations (at C-5 and C-15) in precorrin-6Y, as well as the decarboxylation of the acetate side chain located in ring C, in order to generate precorrin-8X. CbiE and CbiT can be found fused (CbiET, also called CobL), or on separate protein chains (CbiE and CbiT). In the aerobic pathway, a single enzyme called CobL catalyzes the methylations at C-5 and C-15, and the decarboxylation of the C-12 acetate side chain of precorrin-6B.	1.6853e-44
NC_021985.1|WP_020938909.1|1906701_1907352_-|HAD-family-hydrolase	gnl|CDD|319829	cd07527, HAD_ScGPP-like, subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). This subfamily includes Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). GPP1p and GPP2p are involved in glycerol biosynthesis, GPP1 is induced in response to both anaerobic and hyperosmotic stress, GPP2 is induced in response to hyperosmotic or oxidative stress, and during diauxic shift; overexpression of DOG1 or DOG2 confers 2-deoxyglucose resistance. These belong to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.14805e-76
NC_021985.1|WP_020938895.1|1887456_1888278_-|aminodeoxychorismate-lyase	gnl|CDD|238800	cd01559, ADCL_like, ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.	4.13204e-82
NC_021985.1|WP_020938913.1|1908746_1909241_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	4.00285e-16
NC_021985.1|WP_020938908.1|1905256_1906291_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|236863	PRK11153, metN, DL-methionine transporter ATP-binding subunit; Provisional.	4.73714e-165
NC_021985.1|WP_106960551.1|1890458_1891724_-|aminoglycoside-phosphotransferase-family-protein	gnl|CDD|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	3.27635e-11
NC_021985.1|WP_020938905.1|1902749_1903385_-|GNAT-family-N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.90051e-31
NC_021985.1|WP_020938912.1|1908191_1908689_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.35835e-13
NC_021985.1|WP_020938906.1|1903612_1904446_-|ABC-transporter-substrate-binding-protein	gnl|CDD|270315	cd13597, PBP2_lipoprotein_Tp32, The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold. This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.	6.28014e-128
NC_021985.1|WP_020938897.1|1890081_1890378_-|zf-TFIIB-domain-containing-protein	gnl|CDD|379195	pfam13453, zf-TFIIB, Transcription factor zinc-finger.	5.83317e-17
NC_021985.1|WP_020938901.1|1894529_1895348_-|RNA-methyltransferase	gnl|CDD|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	8.67463e-58
NC_021985.1|WP_043475015.1|1892553_1893942_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.58306e-87
NC_021985.1|WP_020938907.1|1904519_1905260_-|ABC-transporter-permease	gnl|CDD|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	3.70197e-99
NC_021985.1|WP_020938893.1|1885946_1886468_+|DsbA-family-protein	gnl|CDD|376526	pfam01323, DSBA, DSBA-like thioredoxin domain. This family contains a diverse set of proteins with a thioredoxin-like structure pfam00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyze one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways. This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs, whose similarity to HCCA isomerases was not previously recognized. Some members have been annotated as dioxygenases, dehydrogenases, or putative glycerol-3-phosphate transfer proteins, but are most likely HCCA isomerase enzymes.	4.53423e-25

Protein sequences

>NC_021985.1|WP_020938902.1|1895421_1896651_-|uroporphyrinogen-III-C-methyltransferase
MAEHPAYPVGLRLSGRRVVVLGGGQVAQRRLPALTAAGADVVLVSPEATPSVEAMADAGEIRWERRPYTEGDLADAWYALIATSDPEANERASAEAERHRVWCVRSDDADRATAWTPATGHSEGVTVAVLTTDARGRDPRHTAAIRDAVVEGLRDGTLVAPHHRTRTAGVALVGGGPGDPDLITVRGRRLLAEADVVIADRLGPRDLLAELPPHVEVIDAAKIPYGRYMAQEAINNALIEHARQGKSVVRLKGGDPFVFGRGMEEVQALAEAGIPCTVVPGISSSISVPGAAGIPVTHRGVAHEFTVVSGHVAPDDERSLVDWPALARLTGTLVILMGVDKIGKIAETLVAHGRPPATPVALVQEGTTAAQRRVDATLATVAETVRAEDVRPPAVIVVGPVVNAGPPVA
>NC_021985.1|WP_020938901.1|1894529_1895348_-|RNA-methyltransferase
MADLITVEDPDDPRLRDYTGLTDVELRRKREPAEGLFIAEGEKVIRRAKEAGYEMRSMLLSAKWIDVMRDVIDELPAPVYAVSPELAEQVTGYHVHRGALASMQRKPLPTAAELLRTARRVVVMESVNDHTNIGAIFRSAAALGMDAVLLSPDCADPLYRRSVKVSMGAVFSVPYARLESWPKGLDSVREAGFTLLALTPDEKARSLDEAAPHRMDRVALMLGAEGDGLSTQALVAADEWVRIPMSHGVDSLNVGAAAAVAFYAVATGRPGA
>NC_021985.1|WP_043475015.1|1892553_1893942_+|serine/threonine-protein-kinase
MNMAMMRLRREDPRVVGSFRLHRRLGAGGMGVVYLGSDKKGQRVALKVIRPDLAEDQEFRSRFAREVSAARRIRGGCTARLVAADLEAERPWFATQYVPGPSLHDKVADEGPLGAAEAAAVGAALSEGLVAVHEAGVVHRDLKPSNILLSPKGPRIIDFGIAWATGASTLTHVGTAVGSPGFLAPEQVRGAAVTPATDVFSLGATLAYASTGDSPFGQGSSEVMLYRVVHEEPQLYGVPDALAPLVRACLAKDPEDRPSTLQLSLRLKEIAAREAHGLADVRPPAPRSAEADRATGRLVDTYPDQQRGQRRTSPGTPLPRGGAPARGGAPGRGGNAGRGGGVASRPGGARPTPAPRVGGPRSGSGSRPAPRSGTGRPAPRPTGTGRRPANPRLLRQRLFVFVVVTLLVALGIAVAQGCQGPARGLGGDDGARRSRSGTASAPPDVTRSPQPRTSAVAFTPEA
>NC_021985.1|WP_020938899.1|1891772_1891949_-|hypothetical-protein
MAHTAPRRTTFAPRRTGRRHPLVATLMALPLAALLLVVFDGWETVATQASSVGVMLGR
>NC_021985.1|WP_106960551.1|1890458_1891724_-|aminoglycoside-phosphotransferase-family-protein
MKPRGDGGAADGTDAGAAGELRRHCAVSGAGRTAWSRTRTRTRTRTRTRTRTRTRTRTAPAPPPAGTRGSTLTPTVHSAEAPVTPDPPALPAQAAPPGRSGRADRSQHPALLPALTARLAATVHPDPGGAPCSCATSPLADRPDATVVRHAGTVAKAHAPGTDATGLARRLAAAARLPDVLLAPLAPEPATVHDRLVTLWPYGAPVDPDDPDAAPWEAAAALLARLHRAAPPDGLPPMRGPEKAALAVGRLCAAPDTSPHPAASAVLRAWRALPAWARGEAPVSGTPALCHGDLHLGQLVRHPAPDGPWRLIDVDDLGLGDPAWDLARPAAWYACGLLPPDEWTRFLTAYREAGGPAVPADGDPWAALDVPARALTVQTAARALAKAAAARRPPDEVELALVDACARMASVPHQLTRRFPA
>NC_021985.1|WP_020938897.1|1890081_1890378_-|zf-TFIIB-domain-containing-protein
MQCPKCHAPMQTYNRNGVQIEQCSGCRGIFLDYGELEALTRLESQWVQPAPPPAPQAYPAPSAPAWGAPHGGGHGGHYGGHHGGHHRHKSFGHMLFSS
>NC_021985.1|WP_020938896.1|1888274_1889372_-|chorismate-binding-protein
MLHHPPRRPSALPPLARFGDRLATGLLDVTGDPAALDSTGFWAVCADFEGRLTCARFAEVRHEPVPAPVPGGWRGPAAGDWTSSLDRAAYTAAVGRIREHIAAGEVYQANLCRVLSAPVAADADVDALTAVLARGNPAPYAGTIRLPGHGVEIATASPELFLRRQGRTVESGPIKGTGRTEADLLEKDYAENVMIVDLVRNDIGRVCATGSVTVPDLCAVEKHPGLVHLVSAVRGELRDGAGWPDLLGAAFPPGSVTGAPKPSALGIIEALETAPRGPYCGGIGWIDADRGTGELAVGIRTFWIDREAGAATLRFGTGAGITWGSDPEGEWRETELKASRLLAVASGAYEEDAAGGAGTDEGALS
>NC_021985.1|WP_020938895.1|1887456_1888278_-|aminodeoxychorismate-lyase
MMIWLDGGLQDVESARVSVFDHGLTVGDGIFETVKATHGQPFALTRHLERLTRSAHGLGLPDPDHDEIRRACAAVLDANPMPLGRLRITYTGGHGPLGSDRGEHGPTLVVALGETARRPDTTAVITVPWTRNERGALTGLKTTSYAENVVALARAHQHGASEALFGNTVGQLCEGTGSNVFVVLDGEIHTPPVSSGCLPGITRALTVEWTGARETDLPLDVLERAEEVFLTSTLRDVQAVHRIDSAELPAVPGPVTAKVMRIFAERAGHDLDP
>NC_021985.1|WP_020938894.1|1886550_1887375_-|GNAT-family-N-acetyltransferase
MTTTLRPTEPLQQQTDGGRSRHYHVCVNSRPVGEIHLCTSPSLGPSVARVEHLRIAEPDQRRGRGTVAALAAEEVARGWGCTSVEAVVPAGAEGALRLVTALGYRPRNRGMEKRLGTTPPALPPGSRARPMDPAEYDAWQEYGFEEYAQQWIALGVPEAAARSKARRDQETLLPDGAGTANTLISVLEHEGTRVGTLWLALKEDKAFVFDVEADRAHRGRGHGRTLMLLAERQAIEAGRPVLGLNVFAGNTPAERLYESLGYDTTDRTFTKPLL
>NC_021985.1|WP_020938893.1|1885946_1886468_+|DsbA-family-protein
MSDSSPAGAEAPVLDVWCELQCPDCRSALDDVRALRARYGDRLELRLRHFPLEKHKHAFAAAQAAEEALEQGRGWEYVEAVLERVAELDRGGEALLVEVARELGLDAEEFDTALIDGRHILIVDADQAEGKALGVTGTPTYVIGGERLDGGKSQEGLRERIEEIADRLLAAGS
>NC_021985.1|WP_020938904.1|1901389_1902616_-|precorrin-6y-C5,15-methyltransferase-(decarboxylating)-subunit-CbiE
MADRVTVIGWDGSPLTDAARGALGAATLVAGAAHHLALPGVPPGAERIRLGSVALAARRIAAHRGTAVVFADGDPGFFGVVRTLRAPEFGLEVEVVPAVSSVAAAFARAGMPWDDAQVVVAHPRTLRRAVNVCRAHTKVAVLTAPGAGPAELGLLLEGVHRTFVICEELGTEHERVAVVTSDNAADHSWRDPNVVIVIGGSGGPAAPAEGGGWFAGRDPAAGPRGWVRPDEEYAAYGGLGEGETQLLRTAQLARLGPRVGDLVWDIGCGSGAFAGEAARAGAAVIAVDRRPESCARAEAVARRFGVQLQVVEGTAPHVLENLPEPDVVRVGGGGAAVVSAVADRRPQRIVTHAATRDEAELVGRGLTEHGYRVECALMQSVELDTRAWTETERNVAFLLSGVLPDRAP
>NC_021985.1|WP_020938905.1|1902749_1903385_-|GNAT-family-N-acetyltransferase
MTSTFPNVSISTERLVLRPLDEDDVPALAEMMNDEQVAAWTDVPQPFTQDGARHWITGYAPTERAAGRGLNLAVTEFLTQRLVGVIQLTGTDWRIRATELSYIIAPWARGEGYASEAALATAQWLLGDQKFERIEIRTAADNTASQQVAQKIGCISEGVLRNACIVHHRSDDGTWSDVRTDFIVWSLLPEDLEGNDEQLAETGFTAYSDWN
>NC_021985.1|WP_020938906.1|1903612_1904446_-|ABC-transporter-substrate-binding-protein
MRNTAKLTTAVLAAGALTLGLSACGSDKGSSTASDYSGPLVVAASPTPHAEILNFVKKNLAKKAGLDLEVKEFQDYIVPNTATEDGSVDANYFQNKPYLDDFNQKRGTHIVPVVTVHLEPLGLYSHKVKSADALKSGATVAVPNDAVNEARALKLLAANGLIGLKDAAGTEATPQDITKNPKNLKFKEVEAAQTVRSLDDVDAAVVNGNYAISAGLKPAKDALVLESAKNSPYGNFLAVKKGNEKDPRVKKLAKLLTSPEVKKFIEDKYQGSVIPSF
>NC_021985.1|WP_020938907.1|1904519_1905260_-|ABC-transporter-permease
MTWSEMQPLLSQASWDTLYMVGWATFISVVGGLPLGILLVLTDRGGLLQNVVASKVIGQVVNIARSMPFIILMVALMGFTRSLTGTTIGREAAIVPLAVGAIPFFARLVETAVREVDGGLVEAVQSMGGNTWTVVRKVLVPESLPSLISSTTTTIVALIGYSAMAGTVGAGGLGDIAIRYGYQRFETQLMWITVAILAVVISLIQFAGDYAARALHGRGGHSGPAPRLRLLRPKPEPARADVSKAA
>NC_021985.1|WP_020938908.1|1905256_1906291_-|ATP-binding-cassette-domain-containing-protein
MITTSGLTKVYRSRGREVTALDGVDLHVREGEVYGVIGQSGAGKSSLIRCVNLLERPTAGTVTVAGRDLTALAGRGSRAGRELRRARSHIGMVFQHFNLLSSRTVQDNVELPLEILGKSGRERSRKALELLDLVGLADKAKAHPAQLSGGQKQRVGIARALAGDPKVLLSDEATSALDPETTRSILQLLRDLNRQLGLTVLLITHEMDVVKSICDSAALMENGRIVESGTVTELLGTPGSELAAALFPVGGEATDADRTVLDVTFHGEAATQPVISQLSRTYNIDISILGAAIDTVGGLQIGRMRIELPGRYEDNVVPVGFLRERGLQIDVVGEEPLLVKEGAK
>NC_021985.1|WP_020938909.1|1906701_1907352_-|HAD-family-hydrolase
MTIHAHALLFDNDGTLVSSLASVERCWTRWAREYGITAEEFGRVELHGRTAVEIVGDLLPARLVPEAVARVEQLEVEDVPHGGVRLLPGTRDFLDSLPADRWAVVTSATGRLAEARLGAVGITPKILVSADDVTRGKPDPEPYLLAARQLGVDPARCVVFEDAPAGLRAGRAAGMTTVALATTHRAHELDADLVVENLAALSALVTHRGLEISVRG
>NC_021985.1|WP_020938910.1|1907421_1907781_+|hypothetical-protein
MLNALTLATGVAALLLAAWCGWAAYRDQPTKDWHFIGMAVVSLLALVQLVVGIVQLARGEKPGQGTAIFVAYLLGAFACVPAAGFMSLAERTRWGSVTVAAGGVVLAVLEVRLYDIWGG
>NC_021985.1|WP_043475020.1|1907782_1908202_+|hypothetical-protein
MTAVQEKPARLITGPGMLLVWFYGVMVVGAVSRSVYQIATDFGRAPLAYSLSAVAGVVYGFITYTLIRGGERARRAALVCCAAELAGVLIVGTWTLADPSAFPDATVWSDYGMGYVFIPVLLPLSAMYWLRRSRTAVTR
>NC_021985.1|WP_020938912.1|1908191_1908689_-|GNAT-family-N-acetyltransferase
MGMSVTISVATEQDAEQIFRLQYLCFQREAALYGNYRIDPLVQSLDSVREEVAADCVFVARLGEEVVGSVRGKATEDGAAAIGKLCVHPRLQGHGIGARLLRAAETALAEQRGATRFRLHTGHRSEGNLRLYRRVGYETVGRSTGADGVELIILEKQAGTYAATA
>NC_021985.1|WP_020938913.1|1908746_1909241_-|sigma-70-family-RNA-polymerase-sigma-factor
MTHDLVAALRPLLTAEASAEAHASGGEPGDLEQAVWLRLLERLETGRPPVDPEGWLRRAVRAEARRSRRTRRHERPYGAEPVDEGRPDPEQLALSAARHRALRDAVRRLPGRCPRLMEALLSPRDLTYREIAGELGISQGSLGPERSRCLGCLRRLLTPEVAAR

Crispr_ID: NC_021985_6

• CRISPR_ID: NC_021985_6
• CRISPR_location: 3487519-3487646
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_6

Consensus_repeat	Method
TGACCCGCACAGGCCGACAGCAGAGGCACGCGGC	CRISPRCasFinder

spacers of NC_021985_6

>6.1|3487553|60|NC_021985|CRISPRCasFinder
CCCGCCGACGGCCGGCAGGGCGTGGGTCGTGGGACCGGACCCGCCACGGCCGGGAGGCCC

CRISPR arrays and Neighbor proteins around NC_021985_6

CRISPR arrays

The CRISPR arrays of NC_021985_6

>merge|NC_021985|6|3487519-3487646|CRISPRCasFinder
TGACCCGCACAGGCCGACAGCAGAGGCACGCGGCCCCGCCGACGGCCGGCAGGGCGTGGGTCGTGGGACCGGACCCGCCACGGCCGGGAGGCCCTGACCCGCCCAGGCCGACAGCAGAGGCACGCGGC

>NC_021985|6|6|3487519-3487646|CRISPRCasFinder
TGACCCGCACAGGCCGACAGCAGAGGCACGCGGC	CCCGCCGACGGCCGGCAGGGCGTGGGTCGTGGGACCGGACCCGCCACGGCCGGGAGGCCC
TGACCCGCCCAGGCCGACAGCAGAGGCACGCGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020940311.1|3488535_3489072_-|HNH-endonuclease	unknown	unknown	gnl|CDD|238038
NC_021985.1|WP_052352155.1|3496411_3497236_+|ABC-2-family-transporter-protein	unknown	unknown	gnl|CDD|253605
NC_021985.1|WP_020940309.1|3485553_3487113_+|MFS-transporter	unknown	unknown	gnl|CDD|365860
NC_021985.1|WP_158506754.1|3478668_3480603_-|hypothetical-protein	unknown	unknown	gnl|CDD|237865
NC_021985.1|WP_020940306.1|3482098_3482548_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043475645.1|3477704_3478394_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020940302.1|3477302_3477608_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020940318.1|3495618_3496419_+|ABC-2-family-transporter-protein	unknown	unknown	gnl|CDD|226953
NC_021985.1|WP_020940301.1|3476606_3477107_-|DUF2267-domain-containing-protein	unknown	unknown	gnl|CDD|378360
NC_021985.1|WP_020940312.1|3489068_3489731_-|HNH-endonuclease	unknown	unknown	unknown
NC_021985.1|WP_193384534.1|3491747_3494018_-|penicillin-binding-protein	unknown	unknown	gnl|CDD|223815
NC_021985.1|WP_020940308.1|3484158_3485502_+|DUF445-domain-containing-protein	unknown	unknown	gnl|CDD|377281
NC_021985.1|WP_020940313.1|3489866_3490334_-|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl|CDD|224146
NC_021985.1|WP_020940300.1|3474885_3476208_-|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NC_021985.1|WP_020940307.1|3482656_3483991_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
NC_021985.1|WP_020940315.1|3490849_3491152_+|co-chaperone-GroES	unknown	unknown	gnl|CDD|197951
NC_021985.1|WP_020940305.1|3480856_3481855_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|181818
NC_021985.1|WP_020940314.1|3490426_3490756_+|DUF3618-domain-containing-protein	unknown	unknown	gnl|CDD|378834
NC_021985.1|WP_020940316.1|3491321_3491642_+|molecular-chaperone	unknown	unknown	gnl|CDD|171110
NC_021985.1|WP_020940310.1|3487818_3488421_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl|CDD|234648

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020940311.1|3488535_3489072_-|HNH-endonuclease	gnl|CDD|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	8.68819e-05
NC_021985.1|WP_052352155.1|3496411_3497236_+|ABC-2-family-transporter-protein	gnl|CDD|253605	pfam06182, ABC2_membrane_6, ABC-2 family transporter protein. This family acts as the transmembrane domain (TMD) of ABC transporters. The family includes proteins responsible for the transport of herbicides.	2.47806e-58
NC_021985.1|WP_020940309.1|3485553_3487113_+|MFS-transporter	gnl|CDD|365860	pfam00083, Sugar_tr, Sugar (and other) transporter.	6.56406e-35
NC_021985.1|WP_158506754.1|3478668_3480603_-|hypothetical-protein	gnl|CDD|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	4.3134e-09
NC_021985.1|WP_020940318.1|3495618_3496419_+|ABC-2-family-transporter-protein	gnl|CDD|226953	COG4587, COG4587, ABC-type uncharacterized transport system, permease component [General function prediction only].	7.55204e-27
NC_021985.1|WP_020940301.1|3476606_3477107_-|DUF2267-domain-containing-protein	gnl|CDD|378360	pfam10025, DUF2267, Uncharacterized conserved protein (DUF2267). This domain, found in various hypothetical bacterial proteins, has no known function.	2.48984e-21
NC_021985.1|WP_020940316.1|3491321_3491642_+|molecular-chaperone	gnl|CDD|171110	PRK11431, PRK11431, quaternary ammonium compound efflux SMR transporter SugE.	9.76285e-29
NC_021985.1|WP_193384534.1|3491747_3494018_-|penicillin-binding-protein	gnl|CDD|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	1.49366e-139
NC_021985.1|WP_020940308.1|3484158_3485502_+|DUF445-domain-containing-protein	gnl|CDD|377281	pfam04286, DUF445, Protein of unknown function (DUF445). Predicted to be a membrane protein.	3.99774e-133
NC_021985.1|WP_020940314.1|3490426_3490756_+|DUF3618-domain-containing-protein	gnl|CDD|378834	pfam12277, DUF3618, Protein of unknown function (DUF3618). This domain family is found in bacteria, and is approximately 50 amino acids in length.	2.45778e-10
NC_021985.1|WP_020940300.1|3474885_3476208_-|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.69554e-77
NC_021985.1|WP_020940307.1|3482656_3483991_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	2.34542e-81
NC_021985.1|WP_020940315.1|3490849_3491152_+|co-chaperone-GroES	gnl|CDD|197951	smart00883, Cpn10, Chaperonin 10 Kd subunit. The chaperonins are 'helper' molecules required for correct folding and subsequent assembly of some proteins. These are required for normal cell growth, and are stress-induced, acting to stabilise or protect disassembled polypeptides under heat-shock conditions. Type I chaperonins present in eubacteria, mitochondria and chloroplasts require the concerted action of 2 proteins, chaperonin 60 (cpn60) and chaperonin 10 (cpn10). The 10 kDa chaperonin (cpn10 - or groES in bacteria) exists as a ring-shaped oligomer of between six to eight identical subunits, while the 60 kDa chaperonin (cpn60 - or groEL in bacteria) forms a structure comprising 2 stacked rings, each ring containing 7 identical subunits. These ring structures assemble by self-stimulation in the presence of Mg2+-ATP. The central cavity of the cylindrical cpn60 tetradecamer provides as isolated environment for protein folding whilst cpn-10 binds to cpn-60 and synchronizes the release of the folded protein in an Mg2+-ATP dependent manner. The binding of cpn10 to cpn60 inhibits the weak ATPase activity of cpn60.	6.37143e-24
NC_021985.1|WP_020940305.1|3480856_3481855_-|helix-turn-helix-domain-containing-protein	gnl|CDD|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	2.04424e-116
NC_021985.1|WP_020940313.1|3489866_3490334_-|thioredoxin-dependent-thiol-peroxidase	gnl|CDD|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	9.63535e-69
NC_021985.1|WP_020940310.1|3487818_3488421_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl|CDD|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	1.43061e-104

Protein sequences

>NC_021985.1|WP_020940309.1|3485553_3487113_+|MFS-transporter
MSTAAEAPSPGNGRTITTNIPARLDRLPWSRWHWTIVIGLGTVWILDGLEVTVVGNIAGRLSEPGSGLAISSGQITGMAAALYVAGACAGALFWGRLTDRFGRKNLFMITLAVYLAATALTAVSFAPWWFFVFRFLTGFGIGGEYAAINSAIDELIPAKYRGRVDLMINGSFWLGAVGGSLLSIVALNTDLLPANLGWRLTFALGAVLALVILLVRRHVPESPRWLLIHGRDREAEEIVTGIERRIESEQGEALAAPEGELEIHQRKDVKFLEIARTIFADYPKRATLGFSLFIGQAFLYNAITFGFGAILTKFFDVPADHTGYYFAVIAIGNFCGPLLLGKLFDTVGRRIMISSTYLLSGLLLFGTAWLFDRGSLSASTLTACWCAVLFFASAGASSAYLTVSEIFPMETRAMSIAFFYALGTAAGGISGPLLFADLTSTGKVGDTVLAFQIGATLMCLAGLVAAALAVRAEGRSLEDVARPLSAVANKAKTATRNARAAGSTRGGHGPTAPPAVGRP
>NC_021985.1|WP_020940308.1|3484158_3485502_+|DUF445-domain-containing-protein
MCGITERVELMEHTETETPDRTTSYRTMTAFTPADEERRRGVRRMKLTATGMLLFVAVVYVLAKWASHQGAGTWTEYVAAAAEAGMVGALADWFAVTALFRHPLGLPIPHTAIIPTKKDQLGVSLGEFVGENFLSQDVVRQRLRAVGIGSRLGAWLAEPDHADRVTAELATALRGALTVLRDSDVQAVVGEAVTRRANAQEIAPGIGKMLERVVADGGHKRVVDLVVGRAHDWLVLHRTDVMVAVEGGAPGWTPRFVDKKVGERVYKELLRFCTEMRDMPSHPARGALDRFLTDFASDLQSDTDTRARVERLKGEVLGRGEVQDLIASAWTAVRSMIVAAAEDERSELRLRVRAALLSLGSRMASEPKVQDKVDTWVEGAAVHVVTTYRKEITSLITDTVAGWDAEHTTRKIEAHIGRDLQFIRINGTVVGSLAGLAIYALSRGLGA
>NC_021985.1|WP_020940307.1|3482656_3483991_-|SGNH/GDSL-hydrolase-family-protein
MTKRHGYAVLSALAALVVILSAVIYVTAAADDGTPRSSFAGDRPHRGSSVAPASTGTWVGSWSTAPAGGEPGTETAGLAGRSVRNVVHASTAGTSARITLSNLYGQSPLTISHASVALSAGDGSAAAAAETMRRLTFDGSGGVVIPAGGQVLSDVVRLTVPHDTDVLVTTYSPTPSGPVTYHPHAQQVSYVAQGDRTEDATGTPYTERTPYWRYVTALDVLSNEAAGTVVVFGDSITDGITSTVGANRRWTDVLAGRLRTAVESGDALPRYGVVNEGISGNQVLADGLGRPAENQSGLGRFGRDALSRTNAKVVVIDLGINDILRNPRLADPDKIVEGLRTLVRQAHARGLKVVGATLMPFEGHRGWTPAREAVRQQVNARIRAGRVYDSVVDFDRSLRDPYDPRRLRPEYDSGDHLHPSDLGFARMGDVFDLTALKGAGQTEL
>NC_021985.1|WP_020940306.1|3482098_3482548_+|hypothetical-protein
MTKLLLAVHVLAAIVAVGPVTVAASMFPPAARRAVAAPDDVRAAQTLGLLHRICRVYAVVGLVVPVFGFATASRMGVLGSAWLIVSIALTALAALVLAALVLPAQTVLVEGGGTRARTVRLAMFTGVFNLLWAAVTILMIVRPGSTTGA
>NC_021985.1|WP_020940305.1|3480856_3481855_-|helix-turn-helix-domain-containing-protein
MHSVAVLALDQVIPFDLSVPIDTFGWARLPDGRPGYRVRVCSPAGEVGAAAGAFAVRAPYGLEALAEADTIVLPGVADPARPLPPGVVDAVRAAAANGTRVASICVGAFVLAATGLLDGLRATTHWKAAGTLAERYPRIVVDPNVLYVDNGQFLTSAGAAAALDMCLHMIRRDHGSAVAAHAARMSVMPLEREGGQAQFIVHDLPPAPAGATLEPLLAWLEAHCDRDLTLDEIAAQARMSSRTLNRRFREQTGTTPLQWLHRARVRRAQYLLETTAYPVERIAAQAGFGSSTAFRDRFRRVVGTSPQAYRRSFQARSFQTQSFQTQSFQTEM
>NC_021985.1|WP_158506754.1|3478668_3480603_-|hypothetical-protein
MPPTCSHCEAQLAGQARFCGACGRPTRAPEPAPEPPPMPAAPPPPPRPAAAPAGPGNPAGTAALLRLAQGDWTGPARIVAYPVAVLLVLTLIVACVSSAQGGVFGQAFGAGLALVLTSVGAELEVALGEQSTTLTASAHLLAVPLTVTLLYAGAWWLGAVRHARRAEAMSERAAPGESALAGVRALLLGTVLTMVLAWVAGTSVPLMDPSTDGASNPMGLMGSEGSMGGGLPDVAERGVSLTVSSSPWAAGWWTALLAAAVLCRTLWRPAITAYVARGGSAQRARLWLTAARDALVCLAVPVAAGGVVSVLALVARGGSSALVPAVAFAPNLGVIALGFGFGVPFDLTLSGLPRVTDEFGGAATGSGDFGVSLFDLHQLSGWLWLSVLLGVGTVLLLSRTALRRGADQAARLRVLVCFVLLFTAAATVTGDSVDVSVEGSLVNVVQAFAADLLPAGAKAQVSVGLSVLGAALGAAVWAALGLFVVPRAARFLRGPGGMEAAGVWVAAAEGAGVDGAGVEGPLLDGIPAQRPAERPAAPAAPATLAAPPAPAPAPIAPPASASAPVPVAPPASAPAPAAAPGTGAATAPVPSAAPVALGRARAGGAGRAGGSGRAGGSGRARGSGRARGSGPGLGGDRVRRVRSR
>NC_021985.1|WP_043475645.1|3477704_3478394_-|hypothetical-protein
MTLLATALVAGGATALALRLGGGAARPHILAATPSPASTLASAGEAVPSRQPATDGEDATTSQSPSGSPSPAVPATVTEADALLKENASLRGRVGAAVEAVRDCSLGPAPLREARKEFLTVADRRDDFVRRLQLLEPDANDDLNAAVEALSQAWTASASADRDYYSWASDVLAAVEEDPVTGCAGSSASDYDVAGGHNEAANKAKGRFARLWAPVAVRYGLTEVKPGDL
>NC_021985.1|WP_020940302.1|3477302_3477608_+|hypothetical-protein
MARVPSAVVAATGLVGGYGVARWTKKRQLGGAVLAVAGAAAAQRWRQQAGGKAAGALTAAYVAAFAGAHPLAKKVGAWPAVFGVAGAVALASWAVADRRHS
>NC_021985.1|WP_020940301.1|3476606_3477107_-|DUF2267-domain-containing-protein
MTVAAPQHRSTIPAPTPRPDTRDSAGEAGWLELTRAVREAGQYATAAEAEAVTRTVLSFLGTHVTGDERVALAQSLPPEAGRVVASQIPVVHPLPAREFVELVASRIEGSTPATARWDVSSVLGVLADQLDEPLTTRVLAQLPHGYAILFGRADLAPPMPSTAPTA
>NC_021985.1|WP_020940300.1|3474885_3476208_-|serine/threonine-protein-kinase
MADVYEGLDMRLRRPVAVKVFRPGPGPQTEESLAMEAVLLAGLQHPGLVTVYDSGRHEDRTYLVMQLVDGPSLHSLLTSGPLPQPRVAALGASLAGALAYVHRTDIVHRDVKPSNVLLDRAGNPHLADFGIALFADATRQTAPDVLTGTAAYLAPEQVEGGRVGPAADVYALGLVLLECLKGTPEYRGTPLEAALARLLRAPEVPAWLPSDFAGLLRSMTSQDPASRPDAAECAQVLAALTPESHPHEPLQTALTPDRGPSLPAPHPATNDLERTHRAAPVLPLRTHDRTEAPAPGAHRRHRLAVGALAALSVALGTTLAVAPGTSGTNANHTDAAATTPDHPRPAPKTKTPSGTPGTPAPKPTTPQAEPISRNLNLISSARPAQTHILSTTHRPPTTPEPENPPARHHPQKPATPPHPHPNPHGHPGKRHHDEGQDGED
>NC_021985.1|WP_020940310.1|3487818_3488421_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MTRLILATRNAGKITELRAILAEAGLPHELVGADAYPDIPDVKETGVTFAENALLKAHALARATGLPAVADDSGLCVDVLGGAPGIFSARWAGRHGDDKANLDLLLAQLSDIAEEHRTAHFACAAALALPDGTERVVEGQLRGVLRHAPAGTNGFGYDPVLQPDGETRTCAELSPEEKNAISHRGKAFRALAPVVRELLG
>NC_021985.1|WP_020940311.1|3488535_3489072_-|HNH-endonuclease
MRYARERKPRPEREELRSAVDASASVAELLRRLGLADNGTQRANVTRWIAADGLVTDHFLGRAHQRGKRSRNAKRPEDVLIRRDTGPRISTRRLRRALLDVGVPEGCARCGVGPEWRGSPLTLEVDHINGDWRDDRRENLRLLCPNCHAITSTWCRGGSRRRSSPGTMTNGQRRWRNG
>NC_021985.1|WP_020940312.1|3489068_3489731_-|HNH-endonuclease
MGAGTYTRERLQEAAHGARTLSEALENLGADPRSPTRRYVRERMRKLGVDVSHFEREGVKWTREVLEAAVAASCSLNDVLRHLGLGVVGGHHTHIGRKIKSYGIDTSHFTPVVRTERMRENRRRRTAAEILVRDASTRAGRVPSGRLKRAMTEMGVEERCALCGIGPVWLGEPLPLEVDHISGDWRDNRLPNLRLLCPNCHSTTDRYRGRGARRDRARAV
>NC_021985.1|WP_020940313.1|3489866_3490334_-|thioredoxin-dependent-thiol-peroxidase
MSERLQPGDPAPDFTLLDADGNEVSLAAHKGRKVIVYFYPAALTPGCTKQACDFTDNLEVLAGAGYDVLGVSPDKPEKLAKFREKESLKVTLLADPDKKVLEAYGAFGEKKLYGKTVVGVIRSTVVVDEEGKVERALYNVKATGHVAKIIKDLGI
>NC_021985.1|WP_020940314.1|3490426_3490756_+|DUF3618-domain-containing-protein
MADTSDTRTPAQIEADIKRRREVLAETLDEIGVRVHPKTIVGDAKAKVVANVDHTVGRAYVEVNRVVSEVRAQFVDEEGAPRLERVVPVALVVVGVVGLLALGARRRKG
>NC_021985.1|WP_020940315.1|3490849_3491152_+|co-chaperone-GroES
MLHDRVLVRQETGEGERRSGGGILIPATAAVGRRLAWAAVVAVGQNVRTVEPGDRVLFDPEDRAEVEVRGVAYVLMRERDLHAVAADRFEGAEDSTGLYL
>NC_021985.1|WP_020940316.1|3491321_3491642_+|molecular-chaperone
MAWVLLVVAGLLEVGWSIGMKYTDGFSRLVPSLFTGAGIVASMVLLSYAARSLPIGTAYGVWVGIGAAGAAVLGMVVLGEPVTAARIFFVCLLLVAVVGLKVTGGH
>NC_021985.1|WP_193384534.1|3491747_3494018_-|penicillin-binding-protein
MVLGTFVMGVLLIVGLFFIGYSMVPIPSANALATKQSNVYLYADGSQLARDGQINRENVTLAQISKPAQHAILAAEDRDFYTESAIDPKAMLRAGWNTATGKGKQSGSTITQQYVKNYYLAQEQTVTRKAKEFFISIKLDRNKSKDEILEGYLNTSYFGRNAYGIQSAAQAYYGKDAADLDPARAAYLAALVNAPSEYDVVAHPENKPAAIARWNYVLDGMVTKGWLSKSERAGMKFPMPKEQTVSTGLSGQRGYLVEAVKDYLTENEILTKEQLEGGGYRITTTFQKSKQNAFVKAVNDQLISKLDKKNNKVDNYVRAGGASVDPKTGKVVALYGGIDYVKQYTNGATRGDFQVGSTFKPFVFTAAVQNSSTTQDGQPITPNTTYDGTNRRPVQGWSGGPYAPANEDQKSYGDITVRKATDLSVNSVYAQMAVDVGPAKVKQTAVDLGVPSGTQDLQPYPSIALGTATASVLDMAESYATLANHGRHGTYTMVEKITKDSTEDVKLPDRQTKQAVSREAADTTTSVLQSVVDNGTAVAAQQAGRPAAGKTGTAEEDTAAWFAGYTPDLATVVSVMGQDPVTAKHRSLYYALGQPRMNGGGPPTAIWAQYTRDALKGKPATEFDLELQQGADVVLPPSSSPSDQPGTTGQDNGGTTNDGGQGNGGTTSTPSGTPTDGGTTGATNGGTTTGGGGTTTDGGGTQGGANGGDAAGGANGGGTTTDGGGTQGGANGGGTATGGGADGGAPGGPGTTGAQP
>NC_021985.1|WP_020940318.1|3495618_3496419_+|ABC-2-family-transporter-protein
MGAGRLYVAVAAGGFRRYATYRAATAAGVFTNTVFGLILVYTYLALWDVKPHLGGYDQAQAVTFVWLGQALYATLAIQGGGFETEFMERIRTGEVAIDLYRPADLQVWWLANDLGRAVFQLLGRGVIPFTFGALVFPTALPHDVGTWLAFLVAVALAMVVSFGIRYLVALTGFWLMDGTGALQALMITGIFCSGMTLPLNAFPGTLGEVVRVLPWAAQVQVPADVLMGQADPLPAFAFQAVWAVVLLAAGRLLQTAAARRVVVQGG
>NC_021985.1|WP_052352155.1|3496411_3497236_+|ABC-2-family-transporter-protein
MGERGAVAEGLRAYRLIAGMWMRSTLTYRASFALAVCGGVLVTGLDFVSILLMFSRVDVLGGYSLAEVAFLYGLSATSFGIADLAIGSAGRLGTRVRDGTLDTLLVRPAPVLAQVAADRFALRRVARITQGALVLGWALVASDIVWTPVKVLMVPGMLVCGGMIFAAVFVVGAAFQFVAQDASEVQNAFTYGGQTLLQYPPTVFGKELVRGVTFMLPLAFVNWVPAAYVLGRPYPLGGVPGWAAFAPPLVAVVCCAAAGLAWRTGLRSYRSTGS

Crispr_ID: NC_021985_7

• CRISPR_ID: NC_021985_7
• CRISPR_location: 3660017-3660128
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_7

Consensus_repeat	Method
CGGGCGACCGCTGCGCGGCACTGAG	CRISPRCasFinder

spacers of NC_021985_7

>7.1|3660042|62|NC_021985|CRISPRCasFinder
GCGGCGGGCGACCGCTGCGCGGCACTGAGGCGGCCGTTCTCCCCCACGCGGCACCGATGCGA

CRISPR arrays and Neighbor proteins around NC_021985_7

CRISPR arrays

The CRISPR arrays of NC_021985_7

>merge|NC_021985|7|3660017-3660128|CRISPRCasFinder
CGGGTGACCGCCGCGCGGCACTGAGGCGGCGGGCGACCGCTGCGCGGCACTGAGGCGGCCGTTCTCCCCCACGCGGCACCGATGCGACGTGCGACCGCTGCGCGGCACTGAG

>NC_021985|7|7|3660017-3660128|CRISPRCasFinder
CGGGTGACCGCCGCGCGGCACTGAG	GCGGCGGGCGACCGCTGCGCGGCACTGAGGCGGCCGTTCTCCCCCACGCGGCACCGATGCGA
CGTGCGACCGCTGCGCGGCACTGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020940438.1|3653476_3653977_+|cysteine-dioxygenase-family-protein	unknown	unknown	gnl|CDD|380416
NC_021985.1|WP_043478395.1|3654981_3656289_+|coenzyme-F420-0:L-glutamate-ligase	unknown	unknown	gnl|CDD|183957
NC_021985.1|WP_020940448.1|3663653_3664688_-|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|133016
NC_021985.1|WP_020940452.1|3669031_3670654_+|LCP-family-protein	unknown	unknown	gnl|CDD|367673
NC_021985.1|WP_020940439.1|3654010_3654970_+|2-phospho-L-lactate-transferase	unknown	unknown	gnl|CDD|237443
NC_021985.1|WP_003975777.1|3652584_3652848_-|WhiB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376791
NC_021985.1|WP_020940453.1|3670725_3671088_-|four-helix-bundle-copper-binding-protein	unknown	unknown	gnl|CDD|153434
NC_021985.1|WP_020940447.1|3661817_3663578_+|LCP-family-protein	unknown	unknown	gnl|CDD|367673
NC_021985.1|WP_020940433.1|3645987_3646359_-|DUF3499-domain-containing-protein	unknown	unknown	gnl|CDD|378788
NC_021985.1|WP_020940455.1|3672623_3673967_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|223936
NC_021985.1|WP_193384535.1|3671285_3672392_-|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|173847
NC_021985.1|WP_078614901.1|3660322_3661588_+|LCP-family-protein	unknown	unknown	gnl|CDD|367673
NC_021985.1|WP_020940435.1|3647198_3648725_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020940441.1|3656413_3657424_+|hypothetical-protein	unknown	unknown	gnl|CDD|223200
NC_021985.1|WP_078614716.1|3666369_3666945_-|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|224523
NC_021985.1|WP_106960578.1|3648721_3652393_-|glycosyltransferase	unknown	unknown	gnl|CDD|224137
NC_021985.1|WP_020940451.1|3667037_3668348_+|LCP-family-protein	unknown	unknown	gnl|CDD|367673
NC_021985.1|WP_020940442.1|3657510_3658593_-|NDP-sugar-synthase	unknown	unknown	gnl|CDD|224129
NC_021985.1|WP_020940434.1|3646759_3647143_+|metallopeptidase-family-protein	unknown	unknown	gnl|CDD|240574
NC_021985.1|WP_020940449.1|3664939_3666313_+|LCP-family-protein	unknown	unknown	gnl|CDD|367673

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020940438.1|3653476_3653977_+|cysteine-dioxygenase-family-protein	gnl|CDD|380416	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain. This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	4.64238e-22
NC_021985.1|WP_043478395.1|3654981_3656289_+|coenzyme-F420-0:L-glutamate-ligase	gnl|CDD|183957	PRK13294, PRK13294, F420-0--gamma-glutamyl ligase; Provisional.	0
NC_021985.1|WP_106960578.1|3648721_3652393_-|glycosyltransferase	gnl|CDD|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	5.84267e-30
NC_021985.1|WP_020940452.1|3669031_3670654_+|LCP-family-protein	gnl|CDD|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	5.93959e-47
NC_021985.1|WP_020940439.1|3654010_3654970_+|2-phospho-L-lactate-transferase	gnl|CDD|237443	PRK13606, PRK13606, LPPG:FO 2-phospho-L-lactate transferase; Provisional.	3.83938e-174
NC_021985.1|WP_003975777.1|3652584_3652848_-|WhiB-family-transcriptional-regulator	gnl|CDD|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.95518e-28
NC_021985.1|WP_020940453.1|3670725_3671088_-|four-helix-bundle-copper-binding-protein	gnl|CDD|153434	cd08026, DUF326, Cysteine-rich 4 helical bundle widely conserved in bacteria. This functionally uncharacterized protein forms a 4-helical bundle with a bromodomain-like topology. It is present in major bacterial lineages and contains highly conserved cysteines in a repeated pattern, whose sidechains appear buried. Some family members have been (mis)annotated as putative ferredoxins.	5.51491e-20
NC_021985.1|WP_020940449.1|3664939_3666313_+|LCP-family-protein	gnl|CDD|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	7.46547e-56
NC_021985.1|WP_020940433.1|3645987_3646359_-|DUF3499-domain-containing-protein	gnl|CDD|378788	pfam12005, DUF3499, Protein of unknown function (DUF3499). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.	1.37389e-57
NC_021985.1|WP_020940455.1|3672623_3673967_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl|CDD|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NC_021985.1|WP_193384535.1|3671285_3672392_-|acyl-CoA-dehydrogenase-family-protein	gnl|CDD|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
NC_021985.1|WP_078614901.1|3660322_3661588_+|LCP-family-protein	gnl|CDD|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	3.33179e-58
NC_021985.1|WP_020940441.1|3656413_3657424_+|hypothetical-protein	gnl|CDD|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	3.66176e-25
NC_021985.1|WP_078614716.1|3666369_3666945_-|acyl-CoA-thioesterase	gnl|CDD|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	3.0244e-48
NC_021985.1|WP_020940447.1|3661817_3663578_+|LCP-family-protein	gnl|CDD|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	1.19379e-55
NC_021985.1|WP_020940451.1|3667037_3668348_+|LCP-family-protein	gnl|CDD|367673	pfam03816, LytR_cpsA_psr, Cell envelope-related transcriptional attenuator domain.	3.39877e-56
NC_021985.1|WP_020940442.1|3657510_3658593_-|NDP-sugar-synthase	gnl|CDD|224129	COG1208, GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis].	7.77622e-100
NC_021985.1|WP_020940434.1|3646759_3647143_+|metallopeptidase-family-protein	gnl|CDD|240574	cd12954, MMP_TTHA0227_like_1, Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria. The subfamily includes some uncharacterized bacterial proteins which show high sequence similarity with Thermus thermophilus hypothetical protein TTHA0227. However, they do not contain the conserved HExxH (x could be any amino acid) motif. They may not have any zinc metallo-peptidase activity.	3.12331e-26
NC_021985.1|WP_020940448.1|3663653_3664688_-|glycosyltransferase-family-2-protein	gnl|CDD|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	9.04681e-92

Protein sequences

>NC_021985.1|WP_020940442.1|3657510_3658593_-|NDP-sugar-synthase
MTEAILLVGGKGTRLRPLTVHTPKPMVPAAGVPFLTHQLARARAAGVEHIVLATSYLAEVFEPYFGDGASLGLHIEYVTEEEPLGTGGALRNVASRLHSGPDDPVLIFNGDILTGLDIRALVDTHESTGADVSLHLTRVTDPRAYGLVPTDGSGRVLAFLEKPQTPEEIVTDQINAGAYVFRRSVIDSIPAGRPVSVERETFPGLLSAGAHLQGMVDSTYWLDLGTPAAFVRGSADLVLGRAPSPAVPGRCGDFLVLPTATVAPQAKLTGGTVVGEGASVAEGARVFGSTILPGAVIESGAVVTDSLIGSRARVGERSVLTGTVVGDGAVVGPDNELREGVRVWCDARIPAGAVRFSSDQ
>NC_021985.1|WP_020940441.1|3656413_3657424_+|hypothetical-protein
MAGRFAPRPTRTTVRGGEVAVPAEVPRQVTAPARVRRWVPEGPLDLGLVLGPLRRGPGDPTFRAARDGSVWRATRTPAGPGTLRVHASGGEVRGEAWGPGAEWLLDGLPDLLGAADEPDAFVPRHRVVALARHHRPGLRLTRTGLVLESLIPSVLEQKVTTYEAYRAWRRLVRGFGEPAPGPAGTGEQPMWVMPAPRTWALIPSWEWHRAGVDDKRASTVLRAVRVAARLEQAVGMPPAEARARLQVVPGIGPWTSAEVVQRSHGAADEVTTGDLHLPGIVGWALAGDRHADDAEMLRLLEPYAGQRHRAARLILLSGNTPARRAPKMPKVDIGLL
>NC_021985.1|WP_043478395.1|3654981_3656289_+|coenzyme-F420-0:L-glutamate-ligase
MSDERPQYTVRALSGIPEVQPGDDLAKLIAAAGPGLADGDVLLVTSKIVSKAEGRIVRADDREAAIDAETVRVVARRGTLRIVENRQGLVMAAAGVDASNTPAGTVLLLPEDPDASARAIREGLRDALGVDVGVVVTDTFGRPWRAGLTDVAIGAAGVRVLDDLRGGTDAYGNPLAATVVATADELAAAGDLVKGKAAGRPVAVVRGLARAVTAEHGEGARALVRTARDDMFRLGTSEAVREAVTQRRTVRAFTDEPVDPGAVRRAVAAAVTAPAPHHTTPWRFVLLESAESRVRLLDAMRDAWIADLRRDGRSEESVARRIRRGDVLRNAPYLVVPCLVMDGSHTYGDARRDGAEREMFVVAAGAGVQNLLVALAGERLGSAWVSSTMFCRDVVREVLDLPAGWDPMGAVAVGHPDEEPGPRPERDAEAFIEVR
>NC_021985.1|WP_020940439.1|3654010_3654970_+|2-phospho-L-lactate-transferase
MRIVVLAGGIGGARFLRGLKRAVPDADVTVIGNTGDDIHLFGLKVCPDLDTVMYTLGGGINEEQGWGRTDETFHLKEELAAYGVGPEWFGLGDRDFATHIVRTQMLGAGYPLSAVTEALCERWKPGVRLIPMTDDRVETHVAVDLDGERRAVHFQEYWVRLRASVPAEAVVPVGAEQSKPAPGVLEAIAGADVILFPPSNPVVSIGTILAVPGIREAIAEAGVPVVGLSPIVGDAPVRGMADKVLAAVGVESTAAAVAEHYGSGLLDGWLVDTVDAGVVERVEADGIRCRAVPLMMTDLDAAAQMAREALALAEEVRGA
>NC_021985.1|WP_020940438.1|3653476_3653977_+|cysteine-dioxygenase-family-protein
MNSDSDLQIAGDILEVPHLLQPPREHPATVAEFAGLARDIAADRSQWAHLVRYDATTRWYHRLRTGPGYEVWLLSWVPGQGSGRHDHGRSSGVLAVLEGTLTEHTPRGTHALAPGAQRVFAPGYVHEVVNDTLEPAVSLHLYHPGLTEMPMHAATAPHCEARPVTA
>NC_021985.1|WP_003975777.1|3652584_3652848_-|WhiB-family-transcriptional-regulator
MTELVQQLLVDDADEELGWQERALCAQTDPESFFPEKGGSTREAKKVCLACEVRSECLEYALANDERFGIWGGLSERERRRLKKAAV
>NC_021985.1|WP_106960578.1|3648721_3652393_-|glycosyltransferase
MSVHSHSHAAAQDGAATPEFPRHVVTAVLVSHDGARWLPHALAGLLGQERPVQNAVAADTGSADDSARLVTEALGDDRVLHLARRTGFGQAVEEASRIAPALGPDELPYLKRPSGWDPVTRSWRDDAYDLPELPHGEPVQWLWLLHDDCAPEPDALAQLLRVVDNELELGRDDVAVVGPKLRGWYDRRQLLEVGVSVANSGRRWTGLDRREQDQGQHDHVRTVLSVSTAGMLVRRDVFERLGGFDRRLPLMRDDLDLCWRATAAGHRVLVAPDAVVRHAEAASRERRTVDCVGRTAASPHKVDKAGAVYSLLVNTRAAALPWVLFRLVLGTFVRTLAYLVGKVPGQAVDEIRGLLGTLLRPERILAGRRRRGPAQIDKGELRGLFPPPGATVRATVEQFAGNFSNSSDTDTSSAGRHGGAVESGPGGDDADFLEIEQFARLKRIARKPGPVLFLVLLLVSLVACRALLGGGALSGGALLPAPAGAGDLWSRYLDAWHPVGAGGTPAAPPYLAVVASLASLLFGSTGIAITALLIGSVPLAGLTAYFASRPLVTSRLLRAWAAIAYAFLPAATGALAGGRIGTAVLAVLLPLIARAGVAASGLTHASGARGSWRATWAYALLLTVTTAFTPIVWPVALILGLGVLVLRRGDLVAHGLRFLAQLGTPLLVLAPWSLTLLPTGFFTEAGLPYGASSASALDLLGASPGGPGTVNGLMLVGIVLAALAALLRSERRLGILTAWAVALVGLVFAVLSNRSTWAGPATLVYGIALLAAAALGADGARSRVAEQNFGWRQPVAALIAFASAAGPLLVAAGWMLGGADGPLERRDPVQVPAFVAEDAATRDQARTLVLDSDSTAHVRYTLVRGSGGRMGDAELAAADGENARLDKVVANLVAGSGADQSGQLGGFAVRYVLVHKGAPREVTRVLDATPGLSRLSQQDGSALWRVDRQVSRATIVPAGGSGAALSVAAGPVEIHTTVPSGPGGRVLRLADAASDGWTATLDGRPLTRTTVDGWAQGFRLPADGGTLDVVHEDPVTHTAWLWAQGALAVVLVVLALPGRRRDVDDDLPEEQPLPVQAAAGEGRRARRLRAQAEEGVPGDQQDPGAAPAPEYEHEHDLGQQPETPAVVPQQQSYADWEYAGTEYGGYADGQYQDAGHYQNAGYDQQAYRSDPYQSGGQQQYDPYAYGTGAGEQAPYDPTAYPQGYDPAQHPYGTGSERPDGSQQ
>NC_021985.1|WP_020940435.1|3647198_3648725_-|hypothetical-protein
MKRTTLSLIAGTAALAAVTAFAALDAPAASSAGAGTAKAAAELPVERTSLLCPAPSVSDIADTSYTSFTPVTQGTTGAGKAELRSAAEQSADGTGDGTAGKGKTGKGKKKADAPVLAPKAPGTPATGDTSGADAPALVGTADGKFAPGWTVQETTAVAAGTGRGLLGVACTAPDTEFWFPGAATSADRTDYVHLTNPDDSAAVVDIELYGKNGAIKSAVGDGFTIPPHASKPVLLSTLTDERQTDLTVHVSVRSGRVGAAVQALDDKVGGDWLAAADDPAGSLVLPGIPKDATDVRLIAFTPGDADADLKVRLASPGGLITPAGNETLHVKSGMTTAADLGAVTRGEAGSLVLTPTDRSVPVVAALRVVRGKGAKQETAFIPATAPVGTRATAADNSGKSTTLSVTAPTTTATVKVTASAGSEGGAPATKTYTIKAGTTQDIAAPAPSSGKGTYALTVETVSGGPVYAARTLAATEAGVPGFTIQTLPSDRGLVAVPEADEDLAVLQK
>NC_021985.1|WP_020940434.1|3646759_3647143_+|metallopeptidase-family-protein
MRGPIAPPQVPLAASRAEVFADLVQDSVERLERRWPQLADVDFVVLEVPRLDGRGTEAWSDEAVPLGGIVPAREGRRGRVVVYRRPVEIRTKGRDERAALVHEVVVEQVAELLGLTPETVDPRYGED
>NC_021985.1|WP_020940433.1|3645987_3646359_-|DUF3499-domain-containing-protein
MSPVRRCSRTACGRPAVATLTYVYADSTAVLGPLATYAEPHCYDLCAEHSERLTAPRGWEVVRLLDGSAPARPSGDDLEALANAVREAARPQQRAAEAGGARTVDPMEVARRGHLRVLRSPDN
>NC_021985.1|WP_078614901.1|3660322_3661588_+|LCP-family-protein
MSDSVRPSPGPDPGPGHGSGHGLGNGSSATGEGLARRRRRRWTHGTALGVAVFVAAAAGTGWALYAKLSANITPDERAAAELARYERERPTALVRGAQNILLIGSDTRAGDGNREYGRDLGSERSDTTILLHLAADRRDATAVSLPRDLMVDIPGCRRQDGSQGAPVFAMFNHAFQLGGSACTVRTVEKLTGIRVDHHMVVDFSGFKDMVDAVDGVRVCLKEPIDDKAARLKLPAGPVTLDGEQALGFVRARESLGDGSDTERMERQQRFLGALVDKVQSDDVLLNPVKLYPVLDAATSSLTTDPELASLRGLYQLVRGLRDIPTEHVQFLTVPRESYVYDSNRDQLVEPEAERLFARLRSDQPVVVARDTAPRSPDGGPSGSPSGSPSGAPSRGGPQESAQSPSPAPTFRGSTAAEHACE
>NC_021985.1|WP_020940447.1|3661817_3663578_+|LCP-family-protein
MDAQSRGRAENIDPADQWVLNPNTGEYELRLNNSAAQSPVPGPRRPNPRGGNGSAPRRRPDPAADGTRETGRQRGGEVPPPRSGRRRGTEPEQPQGRRTRRPVKKKGKAKKILAWTAGGTAFVVIAVGAAGYLYLKHLEGNVTTTDVGNAAKDGFSKDDAFNILIIGTDKRTGKGNKGYGDANSVGHADTNILLHVSKDRTNATALSIPRDLVVDVPDCQTIQPDGSEKVIPGSRQVRFNESLGQEGRDPGCTMRTVKEVTGITPDHFVMVDFNAVKTLTTAVGGVDVCLAHAVNDKDSHLKLPAGPSKVEGEQALAFVRTRHSWGNQGDLDRIKVQQQFMASLMRKMTSGDTLTDPSKLLDLAEAATKALTVDKGIGKVSTLKDVALELKKVPTKNISFVTVPVLDNPADGVVHKTVIVNPNAAPPVFDAIRNDVSFTEVKKKKKAAKDAAAARLKGSRSAPSEVRVRVFNGGAQGGSAQSTLQWLQNDKGVLKSENAGNAPEALDKTTLEYAPAQAAQARELAHLMGLPGSALEPGKSVTNAQGLPEMTLTLGKDFKGAGVSLTTPAKAPSVDKSTADKQKCAG
>NC_021985.1|WP_020940448.1|3663653_3664688_-|glycosyltransferase-family-2-protein
MNAKPDVPLPAVSVIMPVLNEERHLRGAVQAILAQEYAGEMEVVIALGPSVDRTDEIAAELVAEDARVHTVPNPTGRTPAALNAAIKASRHPIVVRVDGHGMLSPNYIATAVRLLEETGAQNVGGIMHAEGENDWEHAVAAAMTSKIGVGNAAFHTGGQAGPAETVYLGVFRREALEQQGGYNEEFIRAQDWELNFRIREAGGLIWFSPELRVSYRPRPSVRALAKQYKDYGRWRHVVARYHSGSINVRYLAPPTAVCAIAAGLVVGVALTPWGLVVPGGYLAAIVAGSLPAGRGLPAKARLQIPVALATMHMTWGWGFLTSPKALARKVIASRRPSVRTEPAV
>NC_021985.1|WP_020940449.1|3664939_3666313_+|LCP-family-protein
MRAVSTLSVVVLASAGIGHAVVTSLDSGIARVDAFKDMKNRPSAGHGMNILLVGTDGRDRISEQQRRAYHLGGQPCHCTDTMMIVHISEDRERATVVSLPRDSYAEAPAHVDATTRRQHGPHPIKLNAAYAEGGPQLTVRTVENMTHVKIDHYLEVDFTSFMKTVDVLGGVRLCTTTPLKDSYTGLDLSPGTHTLLGGQALQYVRARHLDSASDLGRMKRQQRFLAALIEKATSSGVLLNPMKFRDVTRAVLGSVRADEGFGTDELLDLGRAMRSFSPSSSEFTTVPIAQMNFAVKGIGSTLKWDAARSAGLFRALRDDRPLTAERPHRGPVPAPVEVDPRQIRVQVANGTGTMGLAKRVDAALAAAGFAATHQPVTAPAHVARTVIFYDPRWDRSARSLAAALPGSELRPVPGQGPLLKVTAGADFKGVHQVRFEDPSRPEANVLRGNEVVCSGDA
>NC_021985.1|WP_078614716.1|3666369_3666945_-|acyl-CoA-thioesterase
MSLRHKVGAMTDQAPDVDQDIPGKPTSASRTTLSHIMTHNDTNLLGTVHGGVIMKLVDDAAGAVAGRHSGGPAVTASMDEMAFLEPVRVGDLVHVKAQVNWTGRTSMEVGVRVLAERWNESAPATQVGSAYLVFAAVDADGKPRRVPQVIPETERDRRRNQEAQIRRTHRLARRRAIRELREKRAAEGIED
>NC_021985.1|WP_020940451.1|3667037_3668348_+|LCP-family-protein
MNDWPEGSDNNRGPRYGRGSAGAQPEGARVMRQVQRGGPVPPGQRGYGTPGPSAPAYGGGVPSQPSYVDGQGYDDGYGDYDSGYNTGHVYGGGPGGPDGPEGTRTRGPRPAPNWRRRIKWTAITLASVLIVTSVATYFWADSKLHRDVDLSKVIDRPDAGSGTNYLIVGSDSRKGMTSDDKKKLHTGSAQGQRTDSMMILHVGDNGDTLLSLPRDSDVEIPSYKGSTSGKVYPGTGRRTKLNAAYAEDGPTLLVRTIEYNTGLHIDHYVEIGFGGFAKIVDAVGGVEITIDKGFKDKDSGADFKSGKQTLNGEEALAFVRTRHAFAAQDLQRTKNQQKFLAALAHQVATPSTVLNPFTFYPTMGAGLDSLTVDKDMGLWDLASMFWAMKGVSGGDGTSLNMPIAGSRGGNLVWDRTKMKTLVNELKNDEKVTVSGN
>NC_021985.1|WP_020940452.1|3669031_3670654_+|LCP-family-protein
MTRSSVDDEGVVPRARRARRPEAENEAEIAGGRSRDSGHRRRTDQAPPRPKRRILRWSALTLSVVILGTAGAGYLYYQHLNANIKKDKLNLGDSDVPQATPNAAGQTPLNVLLIGSDSRNTAKDLKLGGSKADVGRPPLADVQMLVHVSADRSNMSVVSLPRDTMIPIPKCTDPHTGHVYPASTLAMANDSLGRGGPGCTVATWQHLTKIHIDHFMMVDFSGVVDMADAIGGVPVCVQQNVWSHTSDGHGSGLKLKKGTTYVKGQQALQWLRTRYGFEDGTDLGRTHAQHMYMNAMVRQLRENATLSNPGKMRSLAETATKALQVDESLGTIKKLYDLSEEFKKVPTKRITMTTLPTVQWSQDHNRLVPAPQDSDQLLSMVRDDSALDGRGAKHRTEQKSKDPAAADDRIAVQVRNGTGADGQAPVPQRAGVIAQVLQGKGFTEAAKDTTAAAEAKTTLLYPSADLEGDAQAVAKALGVPLKQVRKSTDVSGVTLVVGADWRTGDAYKAAAEPTAAPSSAAVLHGDKKDACMPVQKGFTW
>NC_021985.1|WP_020940453.1|3670725_3671088_-|four-helix-bundle-copper-binding-protein
MTQSGMMPPMTKQMQDCVEACMNCHTICEETMSSCLQMGGQAQMQIMRALMDCSEMTRMCADMMMRRSPLAAEMCAMCARACDMCAEACMSMPDDPQTMRCAEACRRCAEMCRAMAGASM
>NC_021985.1|WP_193384535.1|3671285_3672392_-|acyl-CoA-dehydrogenase-family-protein
MLRDAVRSLVEAKIAPYAAAVDEEARFPQEALDALVANDLHAVHVPEEYGGAGADALATVIVIEEVARACVSSSLIPAVNKLGSLPVILSGSEDLKKKYLGPLAKGDAMFSYCLSEPEAGSDAGGMKTKAVRDGDHWVLNGVKRWITNAGVSEYYTVMAVTDPAKRTKGISAFVVEKSDEGVSFGAPEKKLGIKGSPTREVYFDNVRIPADRMIGEEGTGFATAMKTLDHTRITIAAQALGVAQGALDYAKGYVQERKQFGKPIADFQGIQFMLADMAMKIAAARALTYQAAAASERGDKDLTFQGAAAKCYASDIAMEVTTDAVQLLGGYGYTRDYPVERMMRDAKITQIYEGTNQVQRIVMARNLP
>NC_021985.1|WP_020940455.1|3672623_3673967_+|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MSLKITVIGTGYLGATHAAAMAELGFEVLGLDVVPEKIAMLERGETPMYEPGLEELLRKHVAGIEGSSGRLRFTQDWAEVGAFGDVHFVCVNTPQRHGEYAADMSYVEAAVASLAPHLRGPALVVGKSTVPVGSADRLAAYLAEHAPAGGDAELAWNPEFLREGFAVQDTLHPDRIVVGVRSERAEKLLREVYATPTGEGTPFVVTDFPTAELVKTAANSFLATKISFINAMAEVCEAAGGDVAKLAEAIGYDDRIGKKFLRAGIGFGGGCLPKDIRAFMARAGELGADQALTFLREIDSINMRQRGQMVELARQALGGGPFLGKRVAVLGATFKPDSDDVRDSPALNVAGQIHLQGGQVTVYDPKGMENARKVFPTLGYAESALDAVRAADVVLHLTEWREFRELDPAALGEVAAARLILDGRNALDPELWRRAGWTYRAMGRPTA

Crispr_ID: NC_021985_8

• CRISPR_ID: NC_021985_8
• CRISPR_location: 4033091-4033194
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_8

Consensus_repeat	Method
GGGGTCCGGTCCCCGAGCACGACG	CRISPRCasFinder

spacers of NC_021985_8

>8.1|4033115|56|NC_021985|CRISPRCasFinder
TACCCGTCGGCTTCACCGACCGCTCCCGCGCGGCGACGCCGGCGTGACACACCGCG

CRISPR arrays and Neighbor proteins around NC_021985_8

CRISPR arrays

The CRISPR arrays of NC_021985_8

>merge|NC_021985|8|4033091-4033194|CRISPRCasFinder
GGGGTCCGGTCCCCGAGCACGACGTACCCGTCGGCTTCACCGACCGCTCCCGCGCGGCGACGCCGGCGTGACACACCGCGGGGTCCGGTCACCCGAGCACGACG

>NC_021985|8|8|4033091-4033194|CRISPRCasFinder
GGGGTCCGGTCCCCGAGCACGACG	TACCCGTCGGCTTCACCGACCGCTCCCGCGCGGCGACGCCGGCGTGACACACCGCG
GGGTCCGGTCACCCGAGCACGACG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020940767.1|4028022_4029075_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379112
NC_021985.1|WP_020940773.1|4033376_4033601_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020940771.1|4030732_4031656_+|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl|CDD|235467
NC_021985.1|WP_020940764.1|4024413_4026477_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226482
NC_021985.1|WP_020940765.1|4026507_4027209_-|homeostasis-protein	unknown	unknown	gnl|CDD|281866
NC_021985.1|WP_043475863.1|4023960_4024143_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020940772.1|4031672_4033082_+|PTS-transporter-subunit-EIIC	unknown	unknown	gnl|CDD|181971
NC_021985.1|WP_020940769.1|4029342_4029726_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020940768.1|4029056_4029335_-|DUF4031-domain-containing-protein	unknown	unknown	gnl|CDD|379076
NC_021985.1|WP_078614908.1|4035508_4035790_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_078614736.1|4038014_4038263_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl|CDD|376852
NC_021985.1|WP_020940766.1|4027327_4027972_+|hypothetical-protein	unknown	unknown	gnl|CDD|226789
NC_021985.1|WP_020940780.1|4038288_4039911_-|chaperonin-GroEL	unknown	unknown	gnl|CDD|234573
NC_021985.1|WP_020940778.1|4036748_4036949_+|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NC_021985.1|WP_004986573.1|4040184_4040388_-|cold-shock-protein	unknown	unknown	gnl|CDD|224197
NC_021985.1|WP_020940770.1|4029781_4030687_+|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224651
NC_021985.1|WP_020940779.1|4037193_4038018_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020940775.1|4034266_4035394_-|NADH:flavin-oxidoreductase	unknown	unknown	gnl|CDD|240095
NC_021985.1|WP_020940774.1|4033669_4034242_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020940777.1|4035925_4036765_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020940767.1|4028022_4029075_+|GNAT-family-N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	3.385e-18
NC_021985.1|WP_020940771.1|4030732_4031656_+|N-acetylmuramic-acid-6-phosphate-etherase	gnl|CDD|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	1.08861e-162
NC_021985.1|WP_020940764.1|4024413_4026477_+|AAA-family-ATPase	gnl|CDD|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	7.02239e-67
NC_021985.1|WP_020940765.1|4026507_4027209_-|homeostasis-protein	gnl|CDD|281866	pfam03932, CutC, CutC family. Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.	2.6334e-22
NC_021985.1|WP_020940780.1|4038288_4039911_-|chaperonin-GroEL	gnl|CDD|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NC_021985.1|WP_020940772.1|4031672_4033082_+|PTS-transporter-subunit-EIIC	gnl|CDD|181971	PRK09586, murP, PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed.	2.64682e-96
NC_021985.1|WP_020940768.1|4029056_4029335_-|DUF4031-domain-containing-protein	gnl|CDD|379076	pfam13223, DUF4031, Protein of unknown function (DUF4031). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	1.15863e-35
NC_021985.1|WP_078614736.1|4038014_4038263_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl|CDD|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	9.59058e-13
NC_021985.1|WP_020940766.1|4027327_4027972_+|hypothetical-protein	gnl|CDD|226789	COG4339, COG4339, Uncharacterized protein conserved in bacteria [Function unknown].	2.83392e-47
NC_021985.1|WP_020940778.1|4036748_4036949_+|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	2.58446e-22
NC_021985.1|WP_004986573.1|4040184_4040388_-|cold-shock-protein	gnl|CDD|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.12525e-34
NC_021985.1|WP_020940770.1|4029781_4030687_+|MurR/RpiR-family-transcriptional-regulator	gnl|CDD|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	1.77086e-72
NC_021985.1|WP_020940775.1|4034266_4035394_-|NADH:flavin-oxidoreductase	gnl|CDD|240095	cd04747, OYE_like_5_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	0
NC_021985.1|WP_020940777.1|4035925_4036765_+|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.81509e-07

Protein sequences

>NC_021985.1|WP_020940772.1|4031672_4033082_+|PTS-transporter-subunit-EIIC
MRNDPASTAAAVLARAGGPGNVTSVAHCMTRLRLGVAEPAAVDAEGLRALPGVLGVVTDGAGVQIVLGPGVVEEVTARAEALVREAGPAPARPAGPDAGAGAGAGAAAPRPEATPVKALLRRVANVFVPLIPALIGCGVLAGLNGLLLNSGLLPALTPALTAVASGFMALIAVFVGHNTAKEFGGTPVLGGAVAAVVVYPGVAKVTAFGVHLVPGQGGVLGALAAALLATRVEKWCRGRVPGALDVLLTPTVTVLVSGLATLYGLMYAAGVVAAAIGVAADWLLATTGPAAGLILGGLFLPLVMLGLHQALIPIHTTLIAQQGYTVLLPLLAMAGAGQVGAALAVYVRLRHDVPLRTTIRSALPAGLLGVGEPLIYGVSLPLGRPFVTACAGGAAGGAFVGFFAMLGDKVGATAIGPSGWALFPLLAGNRGPLTAAAVYGGGLLTGYAVGFAATYLFGFTDRSRTATPA
>NC_021985.1|WP_020940771.1|4030732_4031656_+|N-acetylmuramic-acid-6-phosphate-etherase
MTSHDLRSELESLTTEAFRPDLAEIDRLSTLDIARLMNGEDAGVPAAVAARLPQIAAAIDAVAARMSRGGRLVYAGAGTAGRLGVLDASECPPTFNTDPAQVVGLIAGGPQAMVTSVEGAEDSRELARRDLAALGLGPDDTVVGISASGRTPYAIGAVEHARALGALTVGLACNEHSALAAAAEHGIEVVVGPELITGSTRLKAGTAQKLVLNMLSTITMVRLGKTYGNLMVDVRASNDKLRARSRRIVALATGAPEEEIEKALTESGGEVKNAILALLTGVDGPTAARLLEDSGGHLRAALAAAAT
>NC_021985.1|WP_020940770.1|4029781_4030687_+|MurR/RpiR-family-transcriptional-regulator
MTNDVKEIFGGPGGSLAAKVRTLAPSMTRSMQRVAEAVANDPAGCAALTVTGLAELTGTSEATVVRTARLLGYPGYRDLRLALAGLAAQQQSGRAPAITTDIAVDDPLADVVAKLAYEEQQTLADTAASLDTGQLGAAVAALAGARRTDVYGIGASGLVAQDLTQKLLRIGLIAHAHSDPHLAVTNAVQLRTGDVAIAITHSGSTGDVIEPLRVAFEHGATTVAITGRPESPVTQYADHVLTTSTSRESELRPAAMSSRTSQLLVVDCLFVGVAQRTYESAAPALAASYEALAHRHRTRPR
>NC_021985.1|WP_020940769.1|4029342_4029726_-|hypothetical-protein
MKSLSPIEQALHAARALVLADLVAGRVAEADVVSLVEDSVAQRRWWVEQWPDGVGYVAGLVAQDVQDALLERYGRWPLCPVCPSGDPHALDVEPELGPDPHWVCHQAGVKVAAVGSLAQATGGARSS
>NC_021985.1|WP_020940768.1|4029056_4029335_-|DUF4031-domain-containing-protein
MTVYVDPPAWPGHGRLWSHLVSDASYDELHAFAAGLGVPRRAFERDHYDLPSHRYADAVAAGAVEVSSREVVRLLRASGLRRPKGLVQRRSS
>NC_021985.1|WP_020940767.1|4028022_4029075_+|GNAT-family-N-acetyltransferase
MNRAVAGCLATLRPAVDRDWADTTAGRLEWDCRRTAEHVASDLIAYAGQLAGRAQETYVPFGIALDEGTDNTGLLHVIETTGVLLATTVRATPPRVRAFHPYPFGSADREGFAAMGIAEVLLHTHDIAEGLGIAYTPEEDLAESVLGWLFPHVQPGPAAWPTLLWATGRGELPGRAPVTGWAWRNNLVVPAERVTLTGVRPAVARDLRMGGDGGFDWAGDGPFEGTREACGFLLKAYEAGVHRPEFGVFVLVREEDGRAVGGIGFHGAPDEEGRVEIGYDLAEEARGHGYATEALRALAEWVLAREDVRSLFATVERANTASRAVVARAGFVQVSDDGEESGELAYELRR
>NC_021985.1|WP_020940766.1|4027327_4027972_+|hypothetical-protein
MADLDALRLRFARALEGARAPGDGPDPTPYADNLLARWQEPQRHYHTLTHLTAVLDHVDVLADSAADPDVVQLAAWFHDAVYLPDRSENEERSAHLAERALPEAGVPAAKTAEVARLVRLTVTHDPAADDRDGQVLCDADLAVLAAPPSAYAAYTAAVREEYHFVPNDVFRTGRASILRQLLDLPSLFRTSYGQRHWEATARYNLAAELEMLSP
>NC_021985.1|WP_020940765.1|4026507_4027209_-|homeostasis-protein
MSKRAVLEVIALDTEDAVAAQAGGADRLELVTEMAADGLTPSVRTFAGIRAAVDIDLRVMLRLTDGFAAGGPENLDLLVRLAGQLRDAGADQFVLGFLETGGCVDLAAVERVVAALDGCRWTFHRAIDRAADRDALRKQLADLPGLDTYLTAGSADGVDGGLGTLVAEAAHGGEPGYEQQIMVGGGLRLAHVPTLRAAGIEAFHIGGAARTAGWTGPVSETAVREWRTVLDGV
>NC_021985.1|WP_020940764.1|4024413_4026477_+|AAA-family-ATPase
MSTSAREPLDAPLDDPLARERTHLAASRSALRAMREDVEALDISDVTANWVNAAVLARQIDERIKALADLSDTPLFFGRLDYLHAPGAQRAEGAEGERFYIGRRHVHDAGGDPMVIDWRAPVSQPFYRASKKDPMDVGLRRRFGYTGGALTAYEDEHLSDPAEAATTSKLLQREIERPRVGPMRDIVATIQPEQDEIVRSGLGGTVCVQGGPGTGKTAVGLHRVAYLLYAHRERLARTGTLVIGPNKSFLHYIEQVLPALGELSVRQATVDDLVGHVEVRGTDDAAAAIVKGDARMAEVLRRALYAHVTMPTEPVVVVRGSRRWRVPAYELEELVRELLDRDIRYGAAREALPQRIAHAVLVQMERAGEAPDDRVQDTVARNSAVKAAVKAVWPAVDPAKLVLRLLTDADFLAEHAEGLLDEDEQKTVLWAKPVRSVKSARWSAADAVLVDEATDLIERTHSLGHVVLDEAQDLSPMQYRAVGRRCTTGSATVLGDLAQGTTPWATRSWDEALAHLGKRDGAVEELTAGFRVPTDVIAYASRLLPHIAPGLAPVASVRENPGFFEVRTADGTADVVAACEELLGNEGSTGLIAADARVPALAEALAAAGIACLAPGEETTSESRLTLVPASLAKGLEYDYVVLDEPQAVVDGEPDERTGLRRLYVALTRAVSGLIVTHAAPLPAQLG
>NC_021985.1|WP_043475863.1|4023960_4024143_-|hypothetical-protein
MSAATIHPHPAPPPSGATAVDGPHRHFLGDALRAVKVFAEAAFGVVILGEYGEEAGVRRK
>NC_021985.1|WP_020940773.1|4033376_4033601_+|hypothetical-protein
MMKTLLTTAALTVCAAALAAPAHADGRADGHWTATGTARCAGDLALPALASVAPLPKSDAAPACGADSLLHHGR
>NC_021985.1|WP_020940774.1|4033669_4034242_+|hypothetical-protein
MNHAQLTALGRALRLVGEHGEALSADTPDARLHEIKADLRRALDLLDESVTAGAPTTRCPEHPQGPVDESAPDRCLLCETRRRAARRSEFQGGRPRATEAPASGQSRYGVRADRPQPQQRWLPEAWNGREWQLCGTPRRDRHEAEAYLAAQRRGSRPAMAYRLVHEFTDYEVLRIWGTPVQVDIEPMGNL
>NC_021985.1|WP_020940775.1|4034266_4035394_-|NADH:flavin-oxidoreductase
MTVTPPATSRAAQILSRPIALNGLTVPNRIVMAPMTRMFSPGGVPGEDVRSYYARRAAAGVGLIVTEGTYVGHDSAGNSGRVPRFHGEEQLAGWAKVAEDVHAAGGTIVPQLWHIGMVREQGQNPFPDAPAMGPSGLVTAGAEATGKAMTQQDLDDVIGAFARAAADAERIGFDGVEIHGAHGYLLDQFLWEGTNRRTDAYGGDPVARAKFSAEIVAAVRAAVSPEFPVIFRYSQWKQQDYTARLAETPEELEAILTPLAAAGVDVFHASTRRYWLPEFDGSDLNLAGWTKKLTGKPVITVGSVGLDGDFTGAFQGQGSPVKGIDNLLDRMESDEFDMVAVGRALLQDPDWAAKVLADRFEDLKPYDAAALKTLS
>NC_021985.1|WP_078614908.1|4035508_4035790_-|hypothetical-protein
MDERPARTAGEAVERLRAALCGVGIVLPSLRVDPLSVSDEDPYALVDLGRCNLTVASRLAAALDRVPVEPAPPGEALRERVRRLNHESVRGVT
>NC_021985.1|WP_020940777.1|4035925_4036765_+|helix-turn-helix-domain-containing-protein
MPGPKDLDPSSSPRALLGAELRHARERKGLSQDQLGHRLFVSGSFIGQLEAGTRRMQPDCARMLDEALETDGFFQRNCGAAAKSKFEEHFEAVAEAEAQATAIREYTPLLIPGLLQTRAYAQAVNRAHDPMAPEETIEEWTEGRMERVRLLDHPTKPLLWAVLDEASLRRETGGRAVMAEVLRHVAGLARRNRAIVQVLPFSAGAHAAMQSDLKLMEFADAPPLVYHEGVRTGRVEDDPATVAHLRFRYDLLVASALSRDKSLALLEALAEDYAHEEHP
>NC_021985.1|WP_020940778.1|4036748_4036949_+|DUF397-domain-containing-protein
MRNTPDRDLSAAVWIKSSYSGGGNNCLEVATGHPTLVPVRDSKTPQGPRLSFRPQAWSAFVAGLKL
>NC_021985.1|WP_020940779.1|4037193_4038018_+|hypothetical-protein
MANPGYGKRSAPDQHRRTKHDFGHLPPREAAVAAYVDRLPQGADISVKTLAKQLPYGQCALRTALNRIQAAGHLRRGRERLETQDGGSRWITRSWWSRTARDDAWWAAFTRGAVPEDPRPPERAGPTRSRAHVLLAALGRTAPVLSLSAAECAALAPLLTEWFARGATDEAVLRALSEGLPTPVHHPAALVHRRLVDKLPPEPVPHPAPRRILECAECGVPGRPEALPGGVCGGCRSERAPTRLPTPLTAPAIHAHADAIRASMSQRRRERARG
>NC_021985.1|WP_078614736.1|4038014_4038263_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MRTYPLAEARNQLGKLVGRVRHGQEHILITAYGRPAAALIPVSELEELQRLQDDAWPRSVAGPGHARGRYPPPEAGGTALGP
>NC_021985.1|WP_020940780.1|4038288_4039911_-|chaperonin-GroEL
MAKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLRNVAAGANPMALKRGIEKAVEAVSAALLEQAKDVETKEQIASTASISAADTQIGELIAEAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISAYFATDMERMEASLEDPYILIANSKISSVKDLLPLLEKVMQSGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLGDIAILTGGEVISEEVGLKLENATLDLLGRARKVVITKDETTIVDGAGSSDQVNGRVNQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLQASSVFEKLDLEGDEATGANAVKLALEAPLKQIAVNGGLEGGVVVEKVRNLAVGHGLNAATGEYVDMIAEGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEKAAAAAPGGMPGGDMDF
>NC_021985.1|WP_004986573.1|4040184_4040388_-|cold-shock-protein
MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQRVEFEISQGQKGPQADMVRVTA

Crispr_ID: NC_021985_9

• CRISPR_ID: NC_021985_9
• CRISPR_location: 4779024-4779109
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_9

Consensus_repeat	Method
GCGAACTCGGACGTGGTCTCCGG	CRISPRCasFinder

spacers of NC_021985_9

>9.1|4779047|40|NC_021985|CRISPRCasFinder
CTCACCGCCGCCCTTGGACACCTCCAGGCCCGCGGGGATG

CRISPR arrays and Neighbor proteins around NC_021985_9

CRISPR arrays

The CRISPR arrays of NC_021985_9

>merge|NC_021985|9|4779024-4779109|CRISPRCasFinder
GCGAACTCGGACGTGGTCTCCGGCTCACCGCCGCCCTTGGACACCTCCAGGCCCGCGGGGATGGCGAACTCGGACGTGATCTCCGG

>NC_021985|9|9|4779024-4779109|CRISPRCasFinder
GCGAACTCGGACGTGGTCTCCGG	CTCACCGCCGCCCTTGGACACCTCCAGGCCCGCGGGGATG
GCGAACTCGGACGTGATCTCCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_052352323.1|4769027_4769852_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379262
NC_021985.1|WP_020941397.1|4773644_4774931_-|ion-channel-protein	unknown	unknown	gnl|CDD|235148
NC_021985.1|WP_020941408.1|4786921_4787527_+|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl|CDD|236472
NC_021985.1|WP_020941403.1|4779899_4781456_+|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl|CDD|334815
NC_021985.1|WP_020941399.1|4775829_4776195_-|YbjQ-family-protein	unknown	unknown	gnl|CDD|376657
NC_021985.1|WP_020941391.1|4767819_4768089_+|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NC_021985.1|WP_020941398.1|4775053_4775815_+|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133381
NC_021985.1|WP_043476149.1|4781535_4782669_+|zinc-dependent-metalloprotease	unknown	unknown	gnl|CDD|274833
NC_021985.1|WP_078614765.1|4788712_4789081_-|dihydroneopterin-aldolase	unknown	unknown	gnl|CDD|376737
NC_021985.1|WP_020941407.1|4784769_4786809_+|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl|CDD|273520
NC_021985.1|WP_020941395.1|4771601_4772144_+|DinB-family-protein	unknown	unknown	gnl|CDD|368218
NC_021985.1|WP_020941405.1|4782860_4783925_+|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl|CDD|274129
NC_021985.1|WP_020941392.1|4768198_4768672_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_021985.1|WP_020941402.1|4779283_4779775_-|inorganic-diphosphatase	unknown	unknown	gnl|CDD|376376
NC_021985.1|WP_020941410.1|4788104_4788716_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl|CDD|223872
NC_021985.1|WP_043476152.1|4784002_4784563_+|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl|CDD|223707
NC_021985.1|WP_020941396.1|4772209_4773616_-|glutamate-decarboxylase	unknown	unknown	gnl|CDD|130848
NC_021985.1|WP_020941409.1|4787553_4788045_-|DUF3180-domain-containing-protein	unknown	unknown	gnl|CDD|378650
NC_021985.1|WP_043476146.1|4776337_4777492_+|VTT-domain-containing-protein	unknown	unknown	gnl|CDD|182775
NC_021985.1|WP_020941394.1|4769996_4771457_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143469

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_052352323.1|4769027_4769852_+|helix-turn-helix-domain-containing-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.35797e-09
NC_021985.1|WP_020941397.1|4773644_4774931_-|ion-channel-protein	gnl|CDD|235148	PRK03655, PRK03655, putative ion channel protein; Provisional.	1.15955e-160
NC_021985.1|WP_020941408.1|4786921_4787527_+|GTP-cyclohydrolase-I-FolE	gnl|CDD|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	7.89502e-112
NC_021985.1|WP_020941403.1|4779899_4781456_+|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl|CDD|334815	pfam02113, Peptidase_S13, D-Ala-D-Ala carboxypeptidase 3 (S13) family.	4.90604e-54
NC_021985.1|WP_020941399.1|4775829_4776195_-|YbjQ-family-protein	gnl|CDD|376657	pfam01906, YbjQ_1, Putative heavy-metal-binding. From comparative structural analysis, this family is likely to be a heavy-metal binding domain. The domain oligomerizes as a pentamer. The domain is about 100 amino acids long and is found in prokaryotes.	5.41883e-43
NC_021985.1|WP_020941391.1|4767819_4768089_+|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	8.29135e-18
NC_021985.1|WP_020941398.1|4775053_4775815_+|MerR-family-transcriptional-regulator	gnl|CDD|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	6.21365e-49
NC_021985.1|WP_043476149.1|4781535_4782669_+|zinc-dependent-metalloprotease	gnl|CDD|274833	TIGR03883, DUF2342_F420, uncharacterized protein, coenzyme F420 biosynthesis associated. A phylogenetic tree of the DUF2342 family (TIGR03624) consists of two major branches. One of these branches, modeled here, is observed almost entirely to be found in coenzyme F420 biosynthesizing species of the Actinobacterial, Chloroflexi and Archaeal lineages. The few organisms having genes within this family and lacking F420 biosynthesis may either have an undiscovered F420 transporter, or may represent F420-to-FMN revertants. This family includes a Chloroflexus Aurantiacus protein whose crystal structure has been determined (PDB:3CMN_A). This has been annotated as a putative hydrolase, but the support for that assertion is untraceable. There is no cofactor present in the structure.	3.02995e-170
NC_021985.1|WP_078614765.1|4788712_4789081_-|dihydroneopterin-aldolase	gnl|CDD|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	3.11757e-44
NC_021985.1|WP_020941407.1|4784769_4786809_+|ATP-dependent-zinc-metalloprotease-FtsH	gnl|CDD|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_021985.1|WP_020941395.1|4771601_4772144_+|DinB-family-protein	gnl|CDD|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	1.94647e-49
NC_021985.1|WP_020941405.1|4782860_4783925_+|tRNA-lysidine(34)-synthetase-TilS	gnl|CDD|274129	TIGR02432, tRNAIle-lysidine_synthase, tRNA(Ile)-lysidine synthetase, N-terminal domain. The only examples in which the wobble position of a tRNA must discriminate between G and A of mRNA are AUA (Ile) vs. AUG (Met) and UGA (stop) vs. UGG (Trp). In all bacteria, the wobble position of the tRNA(Ile) recognizing AUA is lysidine, a lysine derivative of cytidine. This family describes a protein domain found, apparently, in all bacteria in a single copy. Eukaryotic sequences appear to be organellar. The domain archictecture of this protein family is variable; some, including characterized proteins of E. coli and B. subtilis known to be tRNA(Ile)-lysidine synthetase, include a conserved 50-residue domain that many other members lack. This protein belongs to the ATP-binding PP-loop family ( pfam01171). It appears in the literature and protein databases as TilS, YacA, and putative cell cycle protein MesJ (a misnomer). [Protein synthesis, tRNA and rRNA base modification].	2.15819e-64
NC_021985.1|WP_020941392.1|4768198_4768672_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	4.52559e-21
NC_021985.1|WP_020941402.1|4779283_4779775_-|inorganic-diphosphatase	gnl|CDD|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	7.39789e-83
NC_021985.1|WP_020941410.1|4788104_4788716_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl|CDD|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	8.84524e-66
NC_021985.1|WP_043476152.1|4784002_4784563_+|hypoxanthine-phosphoribosyltransferase	gnl|CDD|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	8.8594e-90
NC_021985.1|WP_020941396.1|4772209_4773616_-|glutamate-decarboxylase	gnl|CDD|130848	TIGR01788, Glutamate_decarboxylase_alpha_GAD-alpha., glutamate decarboxylase. This model represents the pyridoxal phosphate-dependent glutamate (alpha) decarboxylase found in bacteria (low and hi-GC gram positive, proteobacteria and cyanobacteria), plants, fungi and at least one archaon (Methanosarcina). The product of the enzyme is gamma-aminobutyrate (GABA).	0
NC_021985.1|WP_020941409.1|4787553_4788045_-|DUF3180-domain-containing-protein	gnl|CDD|378650	pfam11377, DUF3180, Protein of unknown function (DUF3180). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	9.65186e-32
NC_021985.1|WP_043476146.1|4776337_4777492_+|VTT-domain-containing-protein	gnl|CDD|182775	PRK10847, PRK10847, DedA family protein.	2.07228e-57
NC_021985.1|WP_020941394.1|4769996_4771457_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143469	cd07151, ALDH_HBenzADH, NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like. NADP+-dependent, p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid and other related sequences are included in this CD.	0

Protein sequences

>NC_021985.1|WP_043476146.1|4776337_4777492_+|VTT-domain-containing-protein
MMTLALGPSWLDPNHLLSTYSIWGLLLIVFAESGLLIGFFLPGDSLLFTCGLLITGHKLDFPLWGAIALICLAAVLGDQAGYMFGKKVGPSLFNRPDSRLFKQENVTKAHEFFEKYGPKSLVLARFVPVVRTFTPIIAGVSGMKYRSFVVFNVIGGVLWGAGVTLLGSWLGKHDVVKNNIEAILILIVLVSVVPIAIEFLRARGKARKEAAAGPAERQADPGQFRPPHQSGPVMDDATTRLRRIEPEQPQYRPRHQSQPQQYQEPRQEQGHWDQGGYGDRSYDQQGYPQQHDPQQPAHQQYGQPRYDQQQPAPQQHHGHPGYGGQGHDQQGHDQQGYGRQGYDQQGHEQPGYHQQGYGRQGYDEQGYDEQGYDQQQYPYGHRDR
>NC_021985.1|WP_020941399.1|4775829_4776195_-|YbjQ-family-protein
MGLDDYGGGQGPQPDVLVVTTNDVPGHRVQQVLGEVFGLTVRSRHLGSQIGAGLKSMIGGELKGLTKTLVQTRNQAMERLVEQARARGANGVLMFRFDVTEAADVGTEVCAYGTAVVLARE
>NC_021985.1|WP_020941398.1|4775053_4775815_+|MerR-family-transcriptional-regulator
MGYLVGQVAGFAGITVRTLHHYDEIGLLVPGERTHAGHRRYTGADLDRLQQILFYRELGFPLDEVAALLDDPDTDPAAHLRRQHGLLTARIEKLQKMAAAVEHAMEAHKMGIDLTPEERFEVFGENDPEKYAEETERRWGGTEAYAESQRRAARYTKDDWKRVRAESDEWTARYVALMTAGGLPSGEAAMDLAEEHRLHIGKWFYECPHAMHRCLGGMYVADERFRAFYDSTRPGFADHLSEAIATNADRHTA
>NC_021985.1|WP_020941397.1|4773644_4774931_-|ion-channel-protein
MAQDTEQQARTTRPATPARTLLPLVLPAVAVGVGASLLYIGVSSAAEQLQHVLWGPLPHALGVGPYSVLWMFVMLVATGIAVGLVVWKVPGHAGPDPATTGLNAPALPPLVLPGLLLATALMLAGGPSLGPENPIIAVNVSVAAWLGGRWMRRAPGALWPMLAEAGTIGALFGTPVAAALVISEALAGRPIRGMLWDNLFAPLTAAAVGAMTTTLLFRPAFDLGLPAMGAPHWQDVLAAVVIAPAAALLGLCAVAAFPYVHAAFQRLRHPMLMLPAGGVVLGALAALGGHLTLFKGLAEVSELAHDPAGWTAGQFALMAVVKLAALVVAASSGFRGGRIFPAVFIGTALGLCAHALVPGVPAALGVATAVLGILLAITRQGWVSLFTAAVLVASPAIIALLCIASLPAWLLVTGRPQMQLREDGTPVR
>NC_021985.1|WP_020941396.1|4772209_4773616_-|glutamate-decarboxylase
MALHEGPEKHNERPMSVNPFFGQANPVAEMTQAPPKHRLPDSPLPPDTAAQLVHDELMLDGNSRLNLATFVTTWMEPQAGDLMAECRDKNMIDKDEYPRTAELERRCVAMLADLWNAPDPAAAVGCSTTGSSEACMLAGMALKRRWAKRNADRYPGARPNLVMGVNVQVCWEKFCNFWEVEARLVPMEGDRYHLDPQAAAELCDENTIGVVGILGSTFDGSYEPIADLCAALDALQERTGLDVPVHVDGASGAMVAPFLDEDLVWDFRLPRVASINTSGHKYGLVYPGVGWALWRDGESLPEELVFRVNYLGGDMPTFALNFSRPGAQVVAQYYTFLRLGREGYRAVQQTTRDVATELADRIEALDDFRLLTRGDELPVFAFTTAPGVESYDVFDLSRRLRESGWLVPAYTFPPNREDLSVVRIVCRNGFSRDLADLFMDDLSRLLPELRRQPHPQTRDKAAATSFHH
>NC_021985.1|WP_020941395.1|4771601_4772144_+|DinB-family-protein
MVTHVAAEARGDERGALLAFLEEQRGGIRRALLGLTEEQARSRPSASELSLGGLLKHVAETEQGWLARARQEPPAVPRDESNWHETFQLTGDETVASQLAYWAEVAAGTEKYIRSAPSLDDTFPLPPDPWFPPEGRVSLRWLCLHLIRETARHAGHADIIRESLDGRTAFELVALEQQGG
>NC_021985.1|WP_020941394.1|4769996_4771457_+|aldehyde-dehydrogenase-family-protein
MSSYFSDLAQQYIDGEWRPGTGSWDVIDFNPYDDEKLASITVATVDEVDQAYQAAARAQKQWAATNPYTRRAVFERALRLIEEREQEIADLIIAELGGTRVKAGFELHLAKEFLRESVHLALRPEGRILPSPADGKENRVYRVPVGVVGVISPFNFPFLLSIKSVAPALALGNAVVLKPHQNTPIAGGTLLAKIFEEAGLPGGLLNVVVTDIAEIGDAFIEHPVPKVISFTGSDKVGRHVATVCAANFKRSVLELGGNSALVVLDDADLDYAVDAAVFSRYVHQGQVCMAANRVLVDRSVADEFTEKFVGKVRSLKVGDPRDPQTVIGPVINSAQANALTGTVEQALAEGATALVHGTTTGNLVEPSVLTGLPADSALLRQEVFGPVVFLVPFDGEEEAVRIVNDTPYGLSGAVHTGDVERGVAFARQIDTGMFHVNDGTVHDEPLVPFGGEKHSGIGRLNGETTLEAFTTVKWISVQHGRSGFPF
>NC_021985.1|WP_052352323.1|4769027_4769852_+|helix-turn-helix-domain-containing-protein
MLLGSQLRRLREARGITREAAGYSIRASESKISRMELGRVSFKTRDVEDLLTLYGITDEAERESLLSLAREANVAGWWHSYTDVLPTWFPTYVGLEGAASLIRVYEVQFVHGLLQTEEYARAVVRRGMKGASAADVERRVALRLERQKHLLADNAPEFHIVLDEAALRRPYGDRDVMRGQFQHLIDISERPNVRLQVMPFSFGGHSGESGAFTLLSFPESDLSDVVYVEQLTSALYLDKREDVAQYEQALKELQQDSPGPDESRDLLRGLLQLS
>NC_021985.1|WP_020941392.1|4768198_4768672_-|ATP-binding-protein
MLKPLRQGLPPLDPAAVSDAASCALPARYEAVGEARRFTRGTLDRWDVGDRFDDIALVVSELVTNALRHALPADAVGAEHAPSVRLHLMRWTGRLVCAVRDPSHETPTPRDSDDFSAESGRGLFLVDSFADSWGWHPLAGTLDGKVVWAMFRLGTTG
>NC_021985.1|WP_020941391.1|4767819_4768089_+|DUF397-domain-containing-protein
MDRDVESVYGEYDVYNGMAAAQLDGVAWQKSRHSNSQGSCVEFARLPGGDVAVRNSRFPDGPALVYTRAEIEAMLLGVKDGEFDHLVLG
>NC_021985.1|WP_020941402.1|4779283_4779775_-|inorganic-diphosphatase
MEFDVTIEIPKGSRNKYEVDHETGRIRLDRRLFTSTAYPTDYGFVENTLGEDGDPLDALVILDEPTFPGCLIKCRAIGMFRMTDEAGGDDKLLCVPATDPRVEHLRDIHHVSEFDRLEIQHFFEVYKDLEPGKSVEGANWVGRTDAELEIERSYKRFKETGGH
>NC_021985.1|WP_020941403.1|4779899_4781456_+|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MVRIANAVRPRLARAAAAAKPRVTRLTEAVRPGPDRPSRTRNVRTWQYSAGAATAGLALAAGVVTAAGPWDANGQRTAERDRAAALERSGGADHGSSGTASGAPRPAPSAAAVLAGLDAGADTVSTKKAPPGRKALADVLKPLLNAPALGGTHTASVVDIGTGRRLYGSGAGKALTPASTTKIATAVAALSALGPDHRFTTRTALEPGTGELVLVGGGDPTLTAHRKADGWASLRTLATGTAGALKKRGVHEVTLSYDTTLYSGPALHRIGVNENLAPVSALTVDEGRTDASSSGPVTRVGDPAADAAHKFAGFLNDAGVKTSAPGPSKAGGTAETLATVSSPPLSALVERMLTNSDNDIAEALARHTALASGGQASYAGGAKAVAARLGRLGLPLSGTAFHDGSGLDRDDRLTADLLTALLVKAGDPADPGLRPVLTGLPVAGFTGTLAARYSNGAAGVVRAKTGTLTGVNTLAGTVVDQDGRLLAFAFLASGTTNPPEAQAALDVTATALAGCGCG
>NC_021985.1|WP_043476149.1|4781535_4782669_+|zinc-dependent-metalloprotease
MTSFGGTASPGMVDWNLAVATATRLVRPGPEVSRDEARSVVAELRRHAKASEEHVRGFTRLGTGDTHDTPVLVVDRPGWVRANVAGFRELLKPLLDKMQERRGNSPGNAVLGTVGGKVTGVELGMLLSFLSSRVLGQYETFAPSTRDLPAGENGGGRLLLVAPNIVHVERELDVEPHDFRLWVCLHEETHRTQFTAVPWLRDHLEGEIQSFLAETDVDPMTVLERVRDAAQSLAGGRPEGEEDDGGRSFVELVQTPAQREILGRLTAVMSLLEGHADFVMDGVGPQVVPSVAEIREKFQQRRAKGASRLDLALRKLLGLDAKLRQYRDGERFVRGVVDQVGMDGFNRVWTSPNTLPTKAEIAAPADWVARVHRKAES
>NC_021985.1|WP_020941405.1|4782860_4783925_+|tRNA-lysidine(34)-synthetase-TilS
MGPHPAVAAIRLAVRRVLHDLLTDHSRTPEKAAAATAAPEGARAPGRAERPAPLVLVACSGGADSMALASALAFEAPKLGIRAGGVTVDHGLQPGSGLRADEVVLRLRELGLDPVESIAVTVGREGGPEAAARDARYAALDDAALRHGADAILLGHTRDDQAETVLLGLARGSGIRSLSGMAAVSGADGRYRRPFLHLDRQTARKACMVQSLPVWDDPHNADPAYTRSRLRHEGLPALEKALGKGVVEALARTAQLSRDDADALDAWASQAEASVRDAAGQLECAKLYALPPAVRRRILRRAAIEAGAPAGSLFARHIEEVDRLITGWRGQKAINLPGKVVARRQGGRLVIRQG
>NC_021985.1|WP_043476152.1|4784002_4784563_+|hypoxanthine-phosphoribosyltransferase
MRVDAKDMGADLQQVLITKEEIDAKLAELAAKIDAEYAGKDLLIVGVLKGAVMVMADLARSLSTPVTMDWMAVSSYGAGTQSSGVVRILKDLDTDIKGKHVLIVEDIIDSGLTLSWLINNLGSREPATLKVCTLLRKPDAAKVAIDVEWVGFDIPNEFVVGYGLDYAEKYRNLPFVGTLAPHVYGG
>NC_021985.1|WP_020941407.1|4784769_4786809_+|ATP-dependent-zinc-metalloprotease-FtsH
MDVKRYFRGPVMWIVLAVLAVVVLMQVVGSSGGYKTVDTGQVVAAINDNKVESAKLTTGDEQTVKVTLKDGVKVEGSSKIQASYIGDQGVTIANTLQTKFQDKQIPDGYTVSPSKQNPFVGVLLSLLPFVLIVVVFLFLMNQMQGGGSRVMNFGKSKAKLITKDTPKTTFSDVAGCDEAVEELHEIKEFLQEPAKFQAVGAKIPKGVLLYGRPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKANAPAIVFVDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFDVKGGVILIAATNRPDILDPALLRPGRFDRQIAVDPPDLQGRMEILKVHQKGKPVASDVDLAAVARRTPGMTGADLANVLNEAALLTARSDQKLIDNKALDEAIDRVVAGPQKRTRIMSDKEKKITAYHEGGHALVAAASPNSDPVHKITILSRGRALGYTMVLPDEDKYSTTRNEMLDQLAYMLGGRAAEELVFHDPTTGAANDIEKATNLARAMVTQYGMTERLGAIKFGGDNSEPFLGREMAHQRDYSEEIAALVDEEVKKFIETAHNEAWEILVENRDVLDNLVLALLEKETLGKEEIAEIFASIHKRPPRPAWTGSSRRTPSTRPPVLSPKELALTNGANGASAAISTVKSTASESAPVTEQTPEDRPES
>NC_021985.1|WP_020941408.1|4786921_4787527_+|GTP-cyclohydrolase-I-FolE
MTDPVTLAGDGFIGEFDEKRAENAVRELLIAVGEDPDREGLRDTPARVARAYRELLAGLWQEPEDVLTTTFDLGHDEMVLVKDIEIVSLCEHHLLPFHGVAHVGYIPAETGKITGLSKLARLVEVFARRPQVQERLTTQIADSLVRILEARGAIVVIEAEHMCMSVRGIRKPGAKTTTSAVRGQLRDATTRAEAMSLILAR
>NC_021985.1|WP_020941409.1|4787553_4788045_-|DUF3180-domain-containing-protein
MRELRIRVLVGVFVVAGVLSWAGARLWNSVGTLPSVPLAAPIVLALIAVVLLSTALSLRARFKAQRERRPGAKGVDPLMAARAVVFGQASALVAALVAGMYGGTGVFLLELLDIPTRRDQAIYAGFSVLAGVGVIAAALFLERVCRLPEDDDQNNHAGAEPAA
>NC_021985.1|WP_020941410.1|4788104_4788716_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MTRPFALGHSDPTVQPVPASVVEQVDAADTTLSNPKWAVISIGSNLGNRLETLQGAVDALEDTPGLRVKAVSPVYETEPWGVEPGSQPSYLNAVVALKTTLPPSSLLERAHAVEEAFNRVRDERWGPRTLDVDIVAYAGVTSDDPQLTLPHPRAHERAFVLAPWHDVDPEAQLPGRGPVAELLSALTREGVEARTDLELRLPE
>NC_021985.1|WP_078614765.1|4788712_4789081_-|dihydroneopterin-aldolase
MIRVDRVALRGLKARGHHGVFPREREEGQTFLVDLVLGLDTRPAAADDDLTKTVHYGIVAEEVVAVVEGEPVNLVETLAERIAQTCLKHEHVQEVEVRVHKPDAPITVPFDDVTVTITRSRV

Crispr_ID: NC_021985_10

• CRISPR_ID: NC_021985_10
• CRISPR_location: 5622103-5622190
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_10

Consensus_repeat	Method
ATGCCCCCGGGCTACGGACAGCAGCCGCCCT	CRISPRCasFinder

spacers of NC_021985_10

>10.1|5622134|26|NC_021985|CRISPRCasFinder
CGTATGGTGGCCAGCCGGGCGCGCCC

CRISPR arrays and Neighbor proteins around NC_021985_10

CRISPR arrays

The CRISPR arrays of NC_021985_10

>merge|NC_021985|10|5622103-5622190|CRISPRCasFinder
ATGCCCCCGGGCTACGGACAGCAGCCGCCCTCGTATGGTGGCCAGCCGGGCGCGCCCATGCCGCCGGGCTACGGACAGCAGCCGCCCT

>NC_021985|10|10|5622103-5622190|CRISPRCasFinder
ATGCCCCCGGGCTACGGACAGCAGCCGCCCT	CGTATGGTGGCCAGCCGGGCGCGCCC
ATGCCGCCGGGCTACGGACAGCAGCCGCCCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020942126.1|5612371_5613316_+|NAD(+)-diphosphatase	unknown	unknown	gnl|CDD|225373
NC_021985.1|WP_020942136.1|5624482_5624998_-|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239646
NC_021985.1|WP_020942134.1|5622926_5623607_+|AIM24-family-protein	unknown	unknown	gnl|CDD|376704
NC_021985.1|WP_020942140.1|5628514_5628688_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942139.1|5627893_5628355_+|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl|CDD|238385
NC_021985.1|WP_020942135.1|5623624_5624380_+|AIM24-family-protein	unknown	unknown	gnl|CDD|376704
NC_021985.1|WP_020942132.1|5620506_5621103_+|M48-family-metallopeptidase	unknown	unknown	gnl|CDD|320703
NC_021985.1|WP_020942127.1|5613417_5613660_-|mycoredoxin	unknown	unknown	gnl|CDD|131255
NC_021985.1|WP_020942130.1|5617578_5618976_-|AarF/ABC1/UbiB-kinase-family-protein	unknown	unknown	gnl|CDD|270872
NC_021985.1|WP_020942137.1|5624994_5626455_-|zinc-dependent-metalloprotease	unknown	unknown	gnl|CDD|378392
NC_021985.1|WP_043476393.1|5626648_5627758_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187551
NC_021985.1|WP_106960605.1|5613818_5616083_+|ATP-dependent-DNA-helicase-UvrD2	unknown	unknown	gnl|CDD|223288
NC_021985.1|WP_020942141.1|5628738_5629836_+|PDZ-domain-containing-protein	unknown	unknown	gnl|CDD|226011
NC_021985.1|WP_020942131.1|5618968_5620219_-|TOMM-precursor-leader-peptide-binding-protein	unknown	unknown	gnl|CDD|366360
NC_021985.1|WP_043476395.1|5629911_5630454_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043476390.1|5616737_5617106_+|WhiB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376791
NC_021985.1|WP_078614792.1|5616247_5616565_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942125.1|5610811_5612215_+|dipeptidase	unknown	unknown	gnl|CDD|349929
NC_021985.1|WP_193384492.1|5630597_5633519_+|UPF0182-family-protein	unknown	unknown	gnl|CDD|377101
NC_021985.1|WP_020942129.1|5617102_5617429_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020942126.1|5612371_5613316_+|NAD(+)-diphosphatase	gnl|CDD|225373	COG2816, NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair].	8.33601e-84
NC_021985.1|WP_020942136.1|5624482_5624998_-|NUDIX-hydrolase	gnl|CDD|239646	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.60209e-39
NC_021985.1|WP_020942134.1|5622926_5623607_+|AIM24-family-protein	gnl|CDD|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	7.75003e-43
NC_021985.1|WP_020942139.1|5627893_5628355_+|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl|CDD|238385	cd00756, MoaE, MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.	4.85917e-50
NC_021985.1|WP_020942135.1|5623624_5624380_+|AIM24-family-protein	gnl|CDD|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	2.96281e-34
NC_021985.1|WP_020942132.1|5620506_5621103_+|M48-family-metallopeptidase	gnl|CDD|320703	cd07344, M48_yhfN_like, Peptidase M48 YhfN-like, a novel minigluzincin. M48 YhfN-like protease is considered as a CaaX prenyl protease 1 homolog, with most of the sequences in this family as yet uncharacterized. It contains the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. It is probably associated with the endoplasmic reticulum (ER), regardless of whether its genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. This novel family of related proteins consist of the soluble minimal scaffold similar to the catalytic domains of the integral-membrane metallopeptidase M48 and M56, thus called minigluzincins.	3.41365e-27
NC_021985.1|WP_020942127.1|5613417_5613660_-|mycoredoxin	gnl|CDD|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	2.99725e-34
NC_021985.1|WP_020942130.1|5617578_5618976_-|AarF/ABC1/UbiB-kinase-family-protein	gnl|CDD|270872	cd13970, ABC1_ADCK3, Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3. This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.	1.00016e-95
NC_021985.1|WP_020942137.1|5624994_5626455_-|zinc-dependent-metalloprotease	gnl|CDD|378392	pfam10103, Zincin_2, Zincin-like metallopeptidase. This family of proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. The structure of this family has similarity to Peptidase_M1 (pfam01433, Structure 3CMN).	6.3659e-169
NC_021985.1|WP_043476393.1|5626648_5627758_+|SDR-family-oxidoreductase	gnl|CDD|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.42514e-94
NC_021985.1|WP_106960605.1|5613818_5616083_+|ATP-dependent-DNA-helicase-UvrD2	gnl|CDD|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	2.57987e-102
NC_021985.1|WP_020942141.1|5628738_5629836_+|PDZ-domain-containing-protein	gnl|CDD|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	2.78118e-79
NC_021985.1|WP_020942131.1|5618968_5620219_-|TOMM-precursor-leader-peptide-binding-protein	gnl|CDD|366360	pfam00899, ThiF, ThiF family. This domain is found in ubiquitin activating E1 family and members of the bacterial ThiF/MoeB/HesA family. It is repeated in Ubiquitin-activating enzyme E1.	1.46066e-21
NC_021985.1|WP_043476390.1|5616737_5617106_+|WhiB-family-transcriptional-regulator	gnl|CDD|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	7.12374e-16
NC_021985.1|WP_020942125.1|5610811_5612215_+|dipeptidase	gnl|CDD|349929	cd05680, M20_dipept_like, uncharacterized M20 dipeptidase. Peptidase M20 family, unknown dipeptidase-like subfamily (inferred by homology to be dipeptidases). M20 dipeptidases include a large variety of bacterial enzymes including cytosolic nonspecific dipeptidase (CNDP), Xaa-methyl-His dipeptidase (anserinase),and canosinase. These dipeptidases have been shown to act on a wide range of dipeptides, but not larger peptides. For example, anserinase mainly catalyzes the hydrolysis of N-alpha-acetylhistidine while carnosinase degrades beta-alanyl-L-histidine.	0
NC_021985.1|WP_193384492.1|5630597_5633519_+|UPF0182-family-protein	gnl|CDD|377101	pfam03699, UPF0182, Uncharacterized protein family (UPF0182). This family contains uncharacterized integral membrane proteins.	0

Protein sequences

>NC_021985.1|WP_020942132.1|5620506_5621103_+|M48-family-metallopeptidase
MPADPLHRAGKPQRSTTSQPPSGSGASAIEVRRSTRRRRTVSAYREGDRTVVLIPARMSEAEEQRWVTLMLDKLAAQESRRKLGDAELTERAARLSEQYFGGRARPASVRWVTNQNTRWGSCTPAEGSIRLSHRLQGMPEYVVDYVLCHELAHLLVPGHGPGFWRLLESYPRTERARGYLEGVVAADRLPQVPGAREE
>NC_021985.1|WP_020942131.1|5618968_5620219_-|TOMM-precursor-leader-peptide-binding-protein
MHPMVKPALRRGWRDLDTVQFGMTPAHALTLGPVDTATGGFLDLLNGTRGLPLLREEGRRMDLPDGHVDTLIDRLADAGLLDDTRGGGPAADALRERTDVLDRLRPDLATLSLTTAGPGDALARLAARRAQRVQVRGAGRVGALLASVLSAAGVGEVDVRDTGRVEPWDVTPGGLPAEALHERRDEAARAAVRRAAPDRRARRSRTAPSPGAPVSPGSSRSSAEAPGLSLVILAPRDDVAVHAPDPFSAGPLVASGTPHLYAGVVEATGVVGPLVLPGETACAGCLDQGRTDRDPVWPRLVAQWRSGRARRTGACDVALATTVAGLAAAHALAFLDGESPSGTGTRWEASLPGLTWHSRPVWPHPACACGAAEAARGEHSSGNGEPRATMAVQGPRTQRPRETGAARPTGTWRAHV
>NC_021985.1|WP_020942130.1|5617578_5618976_-|AarF/ABC1/UbiB-kinase-family-protein
MSDLPRKAVTRTAKLAALPLGFAGRATWGLGKRIVGESAEIVGRELQQRTAEQLFKVLGELKGGAMKFGQALSVFESALPEEVAGPYRAALTKLQEAAPPMPTRTVHAVLEERLGADWRDLFEEFEDKPAAAASIGQVHRAVWHDGREVAVKVQYPGAGEALLSDLSQLSRFARLLGPLIPGMDIKPLIAEMRDRVSEELDYALEAEAQAAHAAEFADDPDVVVPAVVHQCEQVLVTEWIDGIPLSEIITDGTQEQRDRAGQLLARFLFSGPARTGLLHADPHPGNFRLLPGDPEDEGDWRLGVLDFGTVDRLPGGLPAPIGISLRMTLDGEAETVYELLCEEGFVKESIELDPDAVLDYLLPIIEPARVESFTFTRSWMRGQAARVADPRSPAYQLGKRLNLPPAYLLIHRVTLSTIGVLCQLGATVRLRDELEDWLPGFAAEDEPGLGSEDGEPGEEEQAAEA
>NC_021985.1|WP_020942129.1|5617102_5617429_+|hypothetical-protein
MNTAGTIDRPLTHDPKKQASMKPSTSEPAGSATTDSRTTSGATGSRQNRTREMQLIQEALARAHMHERLHEAEREHRAIRLATARRMQRRAERASMRARRALAMAVMQ
>NC_021985.1|WP_043476390.1|5616737_5617106_+|WhiB-family-transcriptional-regulator
MQLEAHAPSVPPSRTIPPPGLTEDSTLTPLTALTALDDAIENLGVPVPCRSYDPEVFFAESPADVEYAKSLCRTCPLMEACLAGAKERREPWGVWGGELFVQGVVVARKRPRGRPRKNPVTA
>NC_021985.1|WP_078614792.1|5616247_5616565_+|hypothetical-protein
MISINTSFISAAKMTDRPTVSTCMLGASNQGTGLSGIRAVRPASSVSLAGLPVRERNERPTKALEAVEAQAHAYAFAAGAGFRKQTTQHHLMWAFRGPEPWSDPA
>NC_021985.1|WP_106960605.1|5613818_5616083_+|ATP-dependent-DNA-helicase-UvrD2
MRPQAPACGQPAQQSRTTWQHGHVTPATHSPLFPQAPDSADAVLEGLDPEQREVATALHGPVCVLAGAGTGKTRAITHRIAYGVRAGILQPSTVLAVTFTNRAAGEMRGRLRQLGAQGVQARTFHSAALRQLQYFWPKAVGGSMPRLVDRKIQLVAEAAATRNLRLDRGELRDTTAEIEWAKVTQTVPADYPYAAAKAGRETPRDPAEIAHLYAAYENLKRDRAVIDFEDVLLLTVAVLQDRHDIADQVRAQYQHFVVDEYQDVSPLQQRLLELWLGERDSLCVVGDASQTIYSFTGATPDHLLDFRVRHPGATVVKLVRDYRSTPQVVRLANGLLTQASGRAADHRLELVSQRPPGPDPVFTEYTDEPAEAEGAARRIRELVDAGTPAAEIAILFRTNSQSETYEQALADAGVPYQLRGAERFFDRPEVRKAGIALRGAARFGGNDSLLDDVVDLPSQVRAVLSGEGWTTEPPAGSGAARERWESLAALVNLAHDFAAAHPGATLGDLVAELDERANAQHAPTVQGVTLASLHAAKGLEWDVVFLVGVADGMMPITYAKTDEQIEEERRLLYVGVTRARERLHLSWSLSRAPGGRPNRRPSPFLDGLRPGSATTAGRTGPAAAGGIERGTLAPAAAAPRRRQRTPARCRVCGRSLTDAGEMKLMRCADCPSDMDEGLYERLRAWRAVQARRSGQPDFCVFTDRTLMAIAEAQPDTTAELSRIPGVLSRKLQRHGADILAICAGQDIARDDEED
>NC_021985.1|WP_020942127.1|5613417_5613660_-|mycoredoxin
MQGTVTMYSTTWCGYCRRLKSQMDREGIAYTEINIEQDPESAAFVEKANGGNQTVPTVLFADGSTLTNPSLAQVKQKVAA
>NC_021985.1|WP_020942126.1|5612371_5613316_+|NAD(+)-diphosphatase
MTIRTDHTADRPISLTAPSGIDRAAHHRLDEAWLAAAWSHPTTRCFVVSGGQVLIDETPDGRTELVMTPSFEAPLTEAHRYFLGTDDDGVSYFALQKDALPGRIDQSARPAGLREAGLLLSPRDAGLMVHAVGLENWQRTHRFCSRCGERTVIAAAGHIRRCPACGAEHYPRTDPAVIMAITDVDDRILLGRQVHWPEGRFSTLAGFVEPGESIEQAVRREAFEEAGVTVGPVEYVASQPWPFPSSLMLGFMAHATTTDITVDGDEIHEARWFSREELHAAFESGEVQPPYGISIAARLIEKWYGRPLPTRSVI
>NC_021985.1|WP_020942125.1|5610811_5612215_+|dipeptidase
MSQTPDSAVRTYIDRHRAAFLDDLTAWLRIPSVSAQPDHGPDVRDSADWLAAKLRETGFPTAEVWPTAGAPAVFAEWPSGDPEAPTVLVYGHHDVQPAAREDGWDSDPFEPVVRGNRLYARGAADDKGQVFFHTLGVRAHLAATGRTAPAVNLKLLIEGEEESGSPHFRALVEEHAGRLTADAVIVSDTGMWSEDTPTVCTGMRGLAECEIRLHGPDQDIHSGSFGGAVPNPATAAARLVAALHDEHARVAVPGFYDGIVELTDRERELFAELPFDEPQWLRTAKSRATHGEAGHTTLERIWARPTAEVNGIGGGYQGPGSKTIIPSSAMVKLSFRLVAGQDPDHIEKAVRAWAADRLPAGITHEISFGSATRPCLTPLDHPALQSVARAMGRAFQSPVRFTREGGSGPAADLQEVLGAPVLFLGISVPSDGWHAPNEKVELDLLLKGVETSAYLWGDLAENWRHAP
>NC_021985.1|WP_020942134.1|5622926_5623607_+|AIM24-family-protein
MNQPLAGYAPAPVTARMDNHGNHMLKVAMQTGNDLLARVGSMVAYEGFIQYEPNPPAVRQIARDWITGEGAPLMKCSGDGLLYLADYGADVVVINLNGDGISVNATNLLAFDAHLTWGVERVKGLAKFAGQGLWNTKISGQGWVALTSRGKPIVVDCGGGEDETYVDPDALVAWSPNLKVKGKRSFKAQSLIGRGSGEAYQMAFSGQGIVVVQPSEDSTDRLRFRG
>NC_021985.1|WP_020942135.1|5623624_5624380_+|AIM24-family-protein
MQSPLFAHNDSQNQDRWSLQNKQMLRVTLEGHDDVLARKGTMVAYQGLVEFDAEYRSNGQARARARTGEGLDLMRCHGQGTVLLANLAQYVHVMDVEQDGLTVDSSYVLAMDSSLHHEVIAVDSLYGISGSGKYQLNITGRGKVALMTSGAPLLMQVTPDKYVNCDADAIVAWSTGLRVQMQAQTHSSGVWRRRGSTGEGWELSFMGSGFALVQPSELLPPQNAEIGQGIAAQFGMGQHGARGQNQGNVWS
>NC_021985.1|WP_020942136.1|5624482_5624998_-|NUDIX-hydrolase
MSLHDDAVLVLKGYGDQEELRQVYLDHLDAHPDGMWKACGDGHVTASALVIDPERGRVLLTLHRKLRMWLQMGGHCEPSDATLADAALREGTEESGVAGLTLLPGGPVRLDRHHTPCAWHLDVQYAALAPSGAVEAISDESLDLRWFAYDEVAGVADASVVRLVEAARARL
>NC_021985.1|WP_020942137.1|5624994_5626455_-|zinc-dependent-metalloprotease
MSDTPFGFGLPPEEPEDGDEGKKKDQESGGGQGPANPFGFGLPGAGGFGGPGADNPLAAMFGSLNPTDLGAAFQQLGQMLSYEGGPVNWDMAKQIARQTVAQGTPDGVKDASVGASERSAVQEAVRLADLWLDDATSLPSGAGTAVAWSRAEWVEATLPAWQELVDPVAERVGAAMGDVLPEEMQAMAGPLIGMMRSMGGAMFGTQIGQAVGVLAGEVVGSTDIGLPLGPSGKAALLPANVEAFGRDLSVAQDEVRLYLALREAAHQRLFTHVPWLRSHLFGAVDGYARGIKVDTAKLEDVVGQFDPQNPEQLQDALQQGMFQPEDTPEQKAALARLETALALVEGWVDAVVHAAAKPRLSSADALRETLRRRRATGGPAEQTFATLIGLELRPRRLRDASRLWASLTDARGVDGRDALWHHPDMLPTATDLDDPDGFVHREQMDFSELDKMLGEAAGKPDLRKKTDDEAAGEAENGGEAKGDGTE
>NC_021985.1|WP_043476393.1|5626648_5627758_+|SDR-family-oxidoreductase
MSSPDPQVRAARNPSTTPAVRGPVVAVTGAARGVGALLTERLAASEDIKQVIAIDERRGECESAQWHILDVRDPAIADKLRGADVVVHLALDLDLGSDTAARTAYNVRGTQTVLTAAAAAGVHRVVLCTSAMVYGALPDNELPLSEDAELRATAEATGVGDLLEIERLARRAPRAHPGLNVTVVRPAVLVGGTDTALTRYFESPRLLVVAGSRPAWQFCHVEDLCGALEYAVVEKVEGELAVGCDGWLEQEEVEELSGIRRMELPSAVALGAAARLHRIGLTPSPAGDLAYTMYPWVVSGSRLHDAGWRPRWTNEEVLAELLEEVAGRHTVAGRRLGRKDATAAGAAGATVALLGAAAVVRRARKARRR
>NC_021985.1|WP_020942139.1|5627893_5628355_+|molybdenum-cofactor-biosynthesis-protein-MoaE
MASTHDHPGEQVAPDPVKLIAVRETALSVDEVFRAVGDDAAGGIALFVGTVRNHDGGADVDALGYSCHPSAEDEMRRVAEKVVAEYPVRALAAVHRVGDLKVGDLAVVVAVSCPHRAEAFEACRRLIDDVKHEVPIWKHQTFSDGTEEWVGAC
>NC_021985.1|WP_020942140.1|5628514_5628688_+|hypothetical-protein
MAALAWLLIPFVAAVCAGLWGSWANRTRKARSDGPELDGYARFREAMEKSHTGARGA
>NC_021985.1|WP_020942141.1|5628738_5629836_+|PDZ-domain-containing-protein
MPRRTATMLASTLMLIALLCAGVLIPVPYSEMSPGPTVNTLGDHQGEPVLQITGHRTYPTDGHLNMTTVRVTSADFRMNLVEAVYGWLAHDSKIVPHDTLYPDGKTEEQSSQENAEEFSQSQESAKVAALKELGVPVKSWVIVSTVVKGSPAEGRLHAGDVIKAVDGTAVKQPSDVAKLVTRHKPGQKVVFTVVPAKDQAAAEKAHRTATRTQDVTITTATSDDSGAKRAIVGISAGTDHTFPFTIDIKLADVGGPSAGLMFALGVYDKLTPGSLTGGKFVAGTGTIDDSGNVGPIGGIEMKTVGARDKGAQYFLTPADNCAAAAKDTPGGLTLVKVRTIRDALGALKDIRDGDTAALPKCTTGG
>NC_021985.1|WP_043476395.1|5629911_5630454_-|hypothetical-protein
MSNTPMAASPLTRAVLEIDEYASGLGWDQPARLFALVDTARLRAQEPALAAQLGLQDEPETTGLTPIEQDEVPTDRPLDEFLGTIAWPDAVVGCALTVERLMLPPSAEAQVPQGLSEAKLARWVAEHPERQEVRMTVAVLRDGTRDSALRLREKDSPTEVLTGPDLVPGLAQALSVTFED
>NC_021985.1|WP_193384492.1|5630597_5633519_+|UPF0182-family-protein
MRTLAFQMPDRGGGPTGPRIRAGRPSRRARTLLMTLGVLAVLGMAFTMFAGFWTDWLWYRSVHYSSVFTTTLWTKIGLFFVFGLLMAVAVGFNIWLAHRLRPPLSAMSLEQQSLDRYRMGIAPYKTWLLLAVTALVGLIAGASAAGQWRTWLLWVNGVPFHQKDPQFHLDVAFYAFDLPWYRFLLGFGFAAAILCLIAAALTHYLYGGLRVTSPGARATAAATGHLSVLLGVFVALKAVAYWLDRYGLAVKSSDFKATDNWTGLRYVDANAYLPAKTILFCIAVICALLFFATLWRRTWQLPVIGFGLMVLSAILIGGLYPAIVQKFQVQPNEQAKEAPYVQKNLKATRDAYGIDDTKVNEYAGKSTTPDKTVLRDQVDDTASLRILDPNIVSPTFQQLQQIRNYYGFPTNLDVDRYPKNGKDQDTVIGLRELNLDGIPKNNWINDHFRYTHGYGVVAAKGTEADSEGRPVFTEKNLPSTGDLGSYQQQIYYGEKTTTYSIVGGPQKEVDYSDDEGEKTTSYTGNSGVNLDNPVNRAAYAVAFNEPQILYSGAIGKGSRILYNRTPKDRVEAVAPWLTIDGDAYPAVVDHRIQWIVDAYTTSNGYPYASRTTLGDTTADSLTATNNSRAVVAQQNQVNYIRNSVKATVDAYTGEVKLYQWDTRDPVLKTWMKAFPGTVKPRADISGDLMAHLRYPQDLFKVQRELLTRYHVTDAQTFLSGSEVWEVPDDPTNDSGSAVPPYYLSMKMPDQSAQAFSLTTTFTPNGRDNLSAFMAVDSDPRAADYGKIRILKLPTSTTVDGPKQVQSQFNSESDIAETISLLSRGHSKVEYGNLLTVPLDGGLLYAEPVYVRGGSLKYPLLRKVLVTYEGRTAFKDTLGEALDEVFGVKTSTPPDTGTTNPPDTANPTVRQALQDAQKAIDAGKEALKQPQGPDWDAWAKAQKDLEAALKRAEDAQTKADKADKADKTNGGHKS

Crispr_ID: NC_021985_11

• CRISPR_ID: NC_021985_11
• CRISPR_location: 6045824-6045920
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_11

Consensus_repeat	Method
GTCCCGGTCCGGCGCCTCGCCTC	CRISPRCasFinder

spacers of NC_021985_11

>11.1|6045847|51|NC_021985|CRISPRCasFinder
TGGGGCGTCCCGCGCTCCGGCTTGCGTGGCGCTCCGCCTCGCGCGGCACTC

CRISPR arrays and Neighbor proteins around NC_021985_11

CRISPR arrays

The CRISPR arrays of NC_021985_11

>merge|NC_021985|11|6045824-6045920|CRISPRCasFinder
GTCCCGGTCCGGCGCGTCGCCTCTGGGGCGTCCCGCGCTCCGGCTTGCGTGGCGCTCCGCCTCGCGCGGCACTCCTGCTTACGCGGCGCCTCGCCTC

>NC_021985|11|11|6045824-6045920|CRISPRCasFinder
GTCCCGGTCCGGCGCGTCGCCTC	TGGGGCGTCCCGCGCTCCGGCTTGCGTGGCGCTCCGCCTCGCGCGGCACTC
CTGCTTACGCGGCGCCTCGCCTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020942474.1|6044452_6045661_+|signal-recognition-particle-docking-protein-FtsY	unknown	unknown	gnl|CDD|236686
NC_021985.1|WP_078614801.1|6056736_6057597_-|SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|225136
NC_021985.1|WP_020942469.1|6035814_6036018_+|hypothetical-protein	unknown	unknown	gnl|CDD|378330
NC_021985.1|WP_020942480.1|6053102_6054650_+|signal-recognition-particle-protein	unknown	unknown	gnl|CDD|236780
NC_021985.1|WP_020942478.1|6050206_6050545_+|P-II-family-nitrogen-regulator	unknown	unknown	gnl|CDD|223424
NC_021985.1|WP_020942484.1|6059009_6059429_+|30S-ribosomal-protein-S16	unknown	unknown	gnl|CDD|184724
NC_021985.1|WP_020942483.1|6058097_6058700_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942466.1|6033017_6033590_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942479.1|6050571_6053022_+|[protein-PII]-uridylyltransferase	unknown	unknown	gnl|CDD|235123
NC_021985.1|WP_043476485.1|6031839_6032961_-|winged-helix-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|377630
NC_021985.1|WP_020942472.1|6041734_6042706_-|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|366009
NC_021985.1|WP_020942471.1|6040192_6041611_+|sugar-porter-family-MFS-transporter	unknown	unknown	gnl|CDD|340917
NC_021985.1|WP_020942476.1|6047056_6048535_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942473.1|6042793_6044284_-|cytosine-permease	unknown	unknown	gnl|CDD|251109
NC_021985.1|WP_020942470.1|6036264_6039975_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|274008
NC_021985.1|WP_020942467.1|6033675_6034974_-|CAP-domain-containing-protein	unknown	unknown	gnl|CDD|349398
NC_021985.1|WP_020942468.1|6035152_6035434_+|acylphosphatase	unknown	unknown	gnl|CDD|237712
NC_021985.1|WP_020942475.1|6045936_6046599_-|bifunctional-DNA-primase/polymerase	unknown	unknown	gnl|CDD|214927
NC_021985.1|WP_043476487.1|6048863_6050210_+|ammonium-transporter	unknown	unknown	gnl|CDD|223083
NC_021985.1|WP_078614800.1|6054746_6056690_+|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl|CDD|273520

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020942474.1|6044452_6045661_+|signal-recognition-particle-docking-protein-FtsY	gnl|CDD|236686	PRK10416, PRK10416, signal recognition particle-docking protein FtsY; Provisional.	1.78859e-165
NC_021985.1|WP_078614801.1|6056736_6057597_-|SAM-dependent-methyltransferase	gnl|CDD|225136	COG2226, UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism].	3.52567e-06
NC_021985.1|WP_020942469.1|6035814_6036018_+|hypothetical-protein	gnl|CDD|378330	pfam09969, DUF2203, Uncharacterized conserved protein (DUF2203). This domain, found in various hypothetical bacterial proteins, has no known function.	0.00495113
NC_021985.1|WP_020942480.1|6053102_6054650_+|signal-recognition-particle-protein	gnl|CDD|236780	PRK10867, PRK10867, signal recognition particle protein; Provisional.	0
NC_021985.1|WP_020942478.1|6050206_6050545_+|P-II-family-nitrogen-regulator	gnl|CDD|223424	COG0347, GlnK, Nitrogen regulatory protein PII [Amino acid transport and metabolism].	6.3333e-50
NC_021985.1|WP_020942484.1|6059009_6059429_+|30S-ribosomal-protein-S16	gnl|CDD|184724	PRK14520, rpsP, 30S ribosomal protein S16; Provisional.	7.69846e-70
NC_021985.1|WP_020942479.1|6050571_6053022_+|[protein-PII]-uridylyltransferase	gnl|CDD|235123	PRK03381, PRK03381, PII uridylyl-transferase; Provisional.	0
NC_021985.1|WP_043476485.1|6031839_6032961_-|winged-helix-DNA-binding-domain-containing-protein	gnl|CDD|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	7.55864e-66
NC_021985.1|WP_020942472.1|6041734_6042706_-|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	6.73383e-35
NC_021985.1|WP_020942471.1|6040192_6041611_+|sugar-porter-family-MFS-transporter	gnl|CDD|340917	cd17359, MFS_XylE_like, D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily. This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.84185e-150
NC_021985.1|WP_078614800.1|6054746_6056690_+|ATP-dependent-zinc-metalloprotease-FtsH	gnl|CDD|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_021985.1|WP_020942473.1|6042793_6044284_-|cytosine-permease	gnl|CDD|251109	pfam02133, Transp_cyt_pur, Permease for cytosine/purines, uracil, thiamine, allantoin.	1.03457e-90
NC_021985.1|WP_020942470.1|6036264_6039975_+|AAA-family-ATPase	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0
NC_021985.1|WP_020942467.1|6033675_6034974_-|CAP-domain-containing-protein	gnl|CDD|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	3.86257e-41
NC_021985.1|WP_020942468.1|6035152_6035434_+|acylphosphatase	gnl|CDD|237712	PRK14422, PRK14422, acylphosphatase; Provisional.	2.21084e-50
NC_021985.1|WP_020942475.1|6045936_6046599_-|bifunctional-DNA-primase/polymerase	gnl|CDD|214927	smart00943, Prim-Pol, Bifunctional DNA primase/polymerase, N-terminal. Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities.	6.03301e-20
NC_021985.1|WP_043476487.1|6048863_6050210_+|ammonium-transporter	gnl|CDD|223083	COG0004, AmtB, Ammonia permease [Inorganic ion transport and metabolism].	6.86297e-161

Protein sequences

>NC_021985.1|WP_020942474.1|6044452_6045661_+|signal-recognition-particle-docking-protein-FtsY
METIILAVVIAVVVLGALGGLVVGSRRKKPLPPPPPAAPDITAPPAEPHVGDEAETPRDEPRRTIEEVDLPGGPPVVVEEPPVGPGLEAPEIEIPEPTAGRLVRLRARLSRSQNALGKGLLTLLSREHLDDDTWEEIEDTLLTADVGVQPTQELVERLRERVKVLGTRTPVELRGLLRDELLKLVGTDVDRTVRTEPEDRKPGIVMVVGVNGTGKTTTTGKLARVLVADGRTVVLGAADTFRAAAADQLQTWGERVGAYTVRGPEAGDPASVAFDAVKEGKEMGVDVVLIDTAGRLHTKTGLMDELGKVKRVVEKHAPLDEVLLVLDATTGQNGLVQARVFAEVVDITGIVLTKLDGTAKGGIVVAVQRELGVPVKLIGLGEGADDLAPFEPEAFVDALIGE
>NC_021985.1|WP_020942473.1|6042793_6044284_-|cytosine-permease
MRKTAETDGALETRGIEQVPDHERTARTRGLFPTWVGANISVLLLTMGASLVVAYHLDIWQALVVAVAAPVVSYGLVGLIGIAGKRGGAPGMALSRAVFGQRGNLLPGALIWVARWGWETINAVTGAYAMLTILDIVLGVRADGVLDMVMLLVFVVATFAISGLGINAVQKCNKYATYFFGVFSVLVLVYLAVHTDWSKVTHQGAGSTAAVITGVGMIAAGGVSWIPSAPDFTRYLPRTASSKAIVGTAVGGAGIVVLPMVLMGAVMAVSTPDLASASDPVSFVGEILPTWLAVPYLLIALIGMLLINSMSMYSAGFTAQTLGFRVPRHWAVSVNAVISLVFGGVLMLVATSFLGSFIAFLSLLAVAFSAWVGVFGADMLRRTEYDGRAMTDTTRTSAYWYRGGFSPAAVAAWAIGLAAGLMFTTSDWFTGPLAKNNVIGEYGLGWVATIVISGLLYLVLPKPAVVTAAPDSESAGTTGSAASAAETAEESATAGV
>NC_021985.1|WP_020942472.1|6041734_6042706_-|LLM-class-flavin-dependent-oxidoreductase
MPVTVVRFNLVEPGAGRASLAARYRAALDMAAYADGHGITTVQTEEHHGADNNWLPSPFAFAGAVFGATRNIAVTVSAVIGPLHDPLRLAEEIAVLDLLSGGRLVTVAGIGYRPEEYALFGVDWKRRGRLQDELLETLLKAWTGEEFEYRGRTVRLTPRPYTDPHPLLLVGGSSRAAARRAARLGLPFFPSAHLPELEAYYKERLAEYGTEGWTMMPAAETPLLHLAEDPDRAWAEYGGHFLHEARTYASWQSGQIRSAVRSAATSVAELRAEGVYRILTPDECLALGADSLVLHPLAGGMPVEEGWRSLRLLAERVLPALGG
>NC_021985.1|WP_020942471.1|6040192_6041611_+|sugar-porter-family-MFS-transporter
MTSTAQAPQPGAGTAHPEHLGHVIFIAAAAAMGGFLFGYDSSVINGAVEAIRDRYNIGPAALAQVIAIALIGCAIGAATAGRIADRIGRIRCMQIASVLFTISAVGSALPFALWDLAFWRIVGGFAIGMASVIGPAYIAEVAPPAYRGRLGSFQQAAIVVGIAISQLVNWGLLNAAGGNQRGQLMGLEAWQVMLGVMVIPAVLYGMLSFAIPESPRFLLSVGKRERAKEILAEVEGKGVDLDARVGEIEHAMRSEHKSTFKDLLGGGFFFKPIVWVGIGLSVFQQFVGINVAFYYSSTLWQSVGVDPTQSFFYSFTTSIINIVGTVIAMIFVDRIGRKPLALIGSAGMVVGLALEAWAFSYDLVDGKLPATQGWVALIAAHVFVLFFALSWGVVVWVFLGEMFPNRIRAAALGVAASAQWIANWAITASFPSLASWNLSATYIIYTVFAALSIPFVLKFVKETKGKALEEMG
>NC_021985.1|WP_020942470.1|6036264_6039975_+|AAA-family-ATPase
MHLKALTLRGFKSFASATTLRFEPGITCVVGPNGSGKSNVVDALSWVMGEQGAKSLRGGKMEDVIFAGTTGRPPLGRAEVSLTIDNSDGALPIEYAEVTITRIMFRNGGSEYQINGDTCRLLDIQELLSDSGIGREMHVIVGQGQLDSVLHADPMGRRAFIEEAAGVLKHRKRKEKALRKLDAMKANLARVQDLTDELRRQLKPLGRQAAVARRAAVIQADLRDARLRLLADDLVRLREALAAEIADEAALKERKEAAEQELRKALQREALLEDEVRRLSPRLQRAQQAWYELSQLAERVRGTISLADARVKSATSAPPEERRGRDPEDMEREAARIREQEAELEAALEAAQRALDDTVSHRAELERELAVEERRLKDVARAIADRREGLARLSGQVNAARSRAASAQAEIDRLAAARDEAQERAVRAQEEYETLKAEVDGLDADDVELAERHETAKLRLAEAESALGEAREAVTAAERRRAATQARHEALALGLRRKDGTGILLGARDRLTGVLGPAAELLTVTPGHEVALAAAFGAAADAIAVSTPASAAEAIRLLRKQDGGRAALLLAAPVERTGARTTGNIRTAPDPGGPGSAAEAARAAHPSGSVSLPAQPAAENTAIARPAGDDTLPYPGGTPFAADLVRGPAGLMPAVRRLLRGIVVVGTLEDAEDLVQARPELTAVTAEGDLLGAHFAHGGSAGAPSLLEVQASVDEAAAELAELAVRCEELAGAQRAAAERRSESAALVEELGERRRAADREKSSVAQQLGRLAGQARGAAGEAERSAAAAARAQEALEKAVGEAEELAERLAVAEEMPVEEEPDTSVRDRLAADGANARQTEMEARLQARTHEERVKGLAGRADSLDRAARAEREARARAEQRRARLRHEAAVAEAVAFGARQLLAHVEVSLERAERERAAAEAAKALREQELTAARGAGRDLKSELDKLKDSVHRGEVLGAEKRLRIEQLETKALEELGVEPAGLVAEYGPRELVPPSPAAEGEELPEDPEHPRNRPRPFVRAEQEKRLKAAERAYQQLGKVNPLALEEFAALEERHKFLSEQLEDLKKTRADLLQVVKEVDERVEQVFTEAYRDTAREFEGVFGRLFPGGEGRLVLTDPDNMLTTGVDVEARPPGKKVKRLSLLSGGERSLTAVALLVSIFKARPSPFYVMDEVEAALDDTNLQRLIRIMQELQEASQLIVITHQKRTMEVADALYGVSMQGDGVSKVISQRLR
>NC_021985.1|WP_020942469.1|6035814_6036018_+|hypothetical-protein
MAKALLGYVGGSDPRLLAEMRRLQQRVQDLESELGRIQAENEALTAAASHDRIMESIDAHQAEPALT
>NC_021985.1|WP_020942468.1|6035152_6035434_+|acylphosphatase
MSEDVRLVAWVRGRVQGVGFRWFTRAKALEIGGLSGFALNLGDGRVQVVAEGARHGCEGLLDWLQGDDTPGRVDGVTEIWDTPRGGYDGFAIR
>NC_021985.1|WP_020942467.1|6033675_6034974_-|CAP-domain-containing-protein
MGRHRRSAAGRAAKGRANGVTHTYDSATGGEHPLDSSAGERPRGIAPYLNPEAYAETNAASTAYLYATGDEPSPSPAGNGFPLDDGRSAGDHFGASAFRADDSAPDDFGTDDSPAFGFAQYGDPSDWNDFASDRDPSDVHGRRKKAGRPVRSSLLGISAAVALAGTAAVATGMVPGLQNYQLGGATHTTGGDRVQAGASPGNTAAEQGGTSGTATGPSGGSATSGATRHPASPPAAPKPSASASRSASASPSPSKTATKAPTKTPTRVPSRPASTKPAPAGTAAAPAPSRTAGKAPTASTPPVTVSRENAVEAEVLKLVNEERAKVGCSALAANSSLSKLAETFSGDMAARGFFDHTDPDGASPWDRAAKAGVTDLGGENIARGQADAAAVMAAWMNSPGHRANILNCDYKTLGVGVHFGSGGPWWTQDFGY
>NC_021985.1|WP_020942466.1|6033017_6033590_+|hypothetical-protein
MGATVTEVMHAGHVAPTVGVDRLRSVWSWSSLLYNTDQQAGIPVDKQERFLLPRDYKQLCQAFGAGEFSQVVSVLCADETRVADLLRTWRLLLSNDDSSDGPFAPYRIHAPGKTGGLIPWGMSRAADAFYWQVTDGPIDAWPVLAKTEDSENWHRYEMTATEFLYRILADPGFRPYTVAQSAPGLSFEPA
>NC_021985.1|WP_043476485.1|6031839_6032961_-|winged-helix-DNA-binding-domain-containing-protein
MAVTPPRSAGVLDRWALNRAFLARQLLLARWAMPAEEALERLVGLQAQAPVPPYFGLWTRLAGFRPAELAGLLTERRAVRIALMRGTVHLVTAADCRRLRPCLQPFMERSLATTFGKELDGLDPAEVAAAGRALLERSPLTVGDLSAALRETWPDRSAAALGNVVRNLLPVVQTPPRGVWGRSGRTTYATAEDWLGAPLDAEPDLDSLVLRYLAAFGPATVRDVQAWSGLTRLRAVIERLRPRLVSFRDEEGRELWDLPGAPRPDAGTPAPVRYLAPYDNAILSHADRTRIIGDQHRRAIATRNGLIPGTILVDGFVAGMWRIDGAGGATTLDVQLFHPVSGHRRVELEEEGERLLLFAADGVAGCELRIADA
>NC_021985.1|WP_020942475.1|6045936_6046599_-|bifunctional-DNA-primase/polymerase
MGFTIGGIREIRSGTRRRGRTSECTAVAEFTGLWAWDVVPGARAAAGACSCGRADCPEPGAHPLGFAAPVPAGATLDEVTRAWSEYPGAAVMLPVGRAFDVIEVAEPAGRRALVRLERMGLPLGPVTATPDGRVHFFVAPGAAAELPRLLYRMGWDDPTALDLRGLGPGTYVTAPPSDRGGLGPVRWLRPPALDSATRPPAARLLLGTLAYVAHRSRSRA
>NC_021985.1|WP_020942476.1|6047056_6048535_+|hypothetical-protein
MGGNGGIGENADKRPNELLGSWFVRSGWSKGELARQVNRRARQLGANHISTDTSRVRRWLDGENPREPIPRILSELFSERFGCVVSVEDLGLRATRQSPSASGVDLPWTGPQAVALLSEFSRSDLMLARRGFLGTSLALSAGPSLIEPMQRWLVPTPSAPVPSEPESPLDSRRPGRLSKPELDLLESTTRMFRQWDAQCGGGLRRKAVVGQLHEVTELLQEPQPEATARKLFKVAAELAELAGWMSYDVGLQPTAQKYFVLALHAAKEAGDKPLGSYVLSSMSRQMIHLGRPDDALELIHLAQYGSRDCAGPRTQSMLYAMEARAYANMGQPGKCKRAVRMAEDTFAEADEWDEPDPDWIRFFSEAELYGENSHSFRDLAYVAGRSPAYASLAEPLMQRAVELFAKDAEHQRSYALNLIGMATVHLLRREPERSTDFASQAMEIARKVRSERVNTRIRKTVDTAVRDFGDLTAVADLTDQLAADLPEAAEAV
>NC_021985.1|WP_043476487.1|6048863_6050210_+|ammonium-transporter
MAPAITLAAEAPRLSAANTGFMLICSALVLLMTPGLAFFYGGMVRVKSTLNMLMMSFVSLGIVTILWVLYGFSLAFGTSNGLIGFNSHWLGLSDIGLTELWDGYTIPIFVFMVFQLMFAIITPALISGALADRVKFSAWSLFVVLWVTIVYVPVAHWVWGADGWAYKLGVIDFAGGTAVHINAGAAALGVILVIGKRVGFKKDPMRPHSLPLVMLGAGLLWFGWFGFNAGSWLGNDDGVGALMFVNTQVATAAAMLAWLAYEKIRHGAFTTLGAASGAVAGLVAITPSGGAVSPLGAIAVGAIAGVACAAAVGLKFRFGYDDSLDVVGVHMVGGIIGSLLIGFFATGKGQSAATGVLYGDHSWTQLWKQCAGVGAVLAYSLVVSAVLAFLLDRTIGMRVTEDEEISGIDQAEHAETAYDFSGAGGGVIGSVAASAAAAQTKQTKRVDA
>NC_021985.1|WP_020942478.1|6050206_6050545_+|P-II-family-nitrogen-regulator
MKLITAVVKPHRLDEIKEALQAFGVHGLTVTEASGYGRQRGHTEVYRGAEYTVDLVPKIRIEVLAEDDEAEQLIEVVVKAARTGKIGDGKVWSLPVETAVRVRTGERGPDAL
>NC_021985.1|WP_020942479.1|6050571_6053022_+|[protein-PII]-uridylyltransferase
MTGTDVRNEADDSGPSGYAAARLRLLCEEGRSGPPRRAALAKLTDDWLAGLFTAGARDLRGVSLVAVGGYGRGELSPRSDLDLLLLHDGNAPDAVAALADRLWYPVWDLGLALDHSVRTPAEARRTAGEDLKAHLGLLDARHLAGDLGLTAALRTTVLADWRNQAPKRLPELRDLCAERAERQGELQYLLEPDLKEARGGLRDATALRAVAASWLADAPREGLADARRRLLDARDALHLVTGRATDRLALQEQDQVAAGLGLLDADTLLRQVYEAARVISYAGDVTWREVGRVLRSRSVRPRLRAMLGGGRPVAERSPLAEGVVEQEGEAVLARSARPDRDPVLPLRAAAAAAQAGLPLSLHAVRRLAAVARPLPTPWPAEAREQLVTLLGSGRPTVDVWEALEAEGLISRLLPDWERVRCRPQRNAVHIWTVDRHLIETAVRASELTRRVGRPDLLLVSALLHDIGKGWPGDHSVAGEIIARDVAARIGFDPADATVLATLVRHHLLLVETATRRDLEDPATVRAVADAVGTQSTLELLHALTEADALATGPAAWSSWRGSLVADLVRRVGAVLAGDGPDEPEPAAPTAEQERLAIEAFRTGSPVLALRAQPEPAGEEEAPGAPEPLGVELVIAVPDQPAVLPAVAGVLAVHRLTVRTAELRTLRLPDDVDDGALLLLNWRVAAEYGSLPQAARLRADLVRALDGSLDIAGRLAERDAAYPRRRGWVAPPPRVTVAPAASHHATVIEVRTQDAPGLLFRIGMALEKAGVRVRSMHVSTLGANAVDAFYVTTGTGAPLPDGDAASLARVLEETLRA
>NC_021985.1|WP_020942480.1|6053102_6054650_+|signal-recognition-particle-protein
MFDTLSDRLSATFKNLRGKGRLSEADVDATAREIRIALLEADVALPVVRSFIKNLKERALGAEVSRALNPAQQVLKIVNEELVTILGGETRRLRFAKQPPTVIMLAGLQGAGKTTLAGKLGKWLKDQGHSPLLVAADLQRPNAVNQLSVVADRAGVAVYAPEPGNGVGDPVKVAKDSIDFAKSKVHDIVIVDTAGRLGIDQEMMQQAADIRDAVSPDEILFVVDAMIGQDAVNTAEAFRDGVGFDGVVLSKLDGDARGGAALSIRQITGKPIMFASNGEKLDDFDAFHPDRMASRILDMGDLLTLIEQAEKTFSQEEAAQMASKLASKKGQDFTLDDFLAQMEQVRKMGSISKLLGMLPGMGQIKDQIQNIDERDVDRTAAIIKSMTPVERQDPTIINGSRRARIAKGSGVEVSAVKNLVERFFEARKMMSRMAQGGGIPGMPGIPGMGGGPGRSKKQPKKAKGKQRSGNPMKRKQQELEDAQRREAAGQGGAFGLPQQGGQDFELPDEFKKFMG
>NC_021985.1|WP_078614800.1|6054746_6056690_+|ATP-dependent-zinc-metalloprotease-FtsH
MSNAAPPRQAPDQPWRAEGTPDEPPRRSGGPRLRGGRWWGLLVTAVIVFLLAYFGLNYLGQGNEPTISYTEFSREVGAGNVATIYSKGDAIQGQLKSPRANPEGGGTYSKFRTQRPAFATDKLWQELSSHGVTVTARPVVQERSFLSNLLISLIPIVILAAVWIFFARRIGAGLGGAGGMFGRKPPPKPVGPRPDSKRTTFADVAGIDEVKGELDDVVDFLEHPDAYRRMGAKLPRGVLLAGQPGTGKTLLARAVAGEAGVPFFSASASEFIEMIVGVGASRVRELFAEARKVAPSIIFIDEIDTIGRARGSGASMSGHDEREQTLNQILTEMDGFSGSEGVIVIAATNRADILDPALTRPGRFDRVVNVAPPDRGGREAILRIHTRDIPLAPDVDLPQMARVTPGMTGADLANLANEAALLAVKRKQDQVTAGDLSEALEKVQLGAERTLVMPEEDRRRTAYHESGHALLGMLQPGADPVRKITIVPRGRALGVTMSTPEVERYAHSEEYLRGRIIGALGGMAAEDVVYGVVTTGAENDLEQVTNIARGMVARWGMSERVGRLSALPSDAQQAYGLAAAPHTLDVIDGEMRRIVDECYEEALHKLREHRGRLDALAGALLESETLEEAEAYRIAGIPRLAKESETA
>NC_021985.1|WP_078614801.1|6056736_6057597_-|SAM-dependent-methyltransferase
MTPTLVREHLSHAASAPPRVDLCARARDWSEIQERMLVPLYETVHERLEVGPGTRLLGLRCGSGLALLMALSRGASVTGVDSCPERLALARERLQPDGPRGTRARAGVRLVAGSPGDAAGARTPPYTVVTVFEPIGCRAGDAEGLGELLAAALPRAGHGAAVVLAGWGPPERCATSSVLRVATKLADPLRGAGRWRPARRDDLEEVAHRAGLKPDGSGRVSCPFGYADTDSALRGLLSTGLFDAAVAATDRKQVTKELTEALHPYRREDGTVWMPNVFRYLIARVP
>NC_021985.1|WP_020942483.1|6058097_6058700_+|hypothetical-protein
MSTTQTPPVLAAELAQAWADIQRYHPELPDLAAPESLIGESSSACGHELSFERLLHEAVHGIAAARGVRDTSRAGRYHNRRFLAIAEELGLDHPEEPHPSSGFSLVTLNPEAKRRYRPTMERLQRALKAHTAATSADTSRTFRGPAARHGSSGGGVRVKAVCDCGRNVRVVPSVLAQAPIVCGGCGKPFRIPEVVGAAAS
>NC_021985.1|WP_020942484.1|6059009_6059429_+|30S-ribosomal-protein-S16
MAVKIKLKRLGKIRSPHYRIVVADSRTRRDGRAIEEIGKYHPTYNPSVIEVDADRVAYWLGVGAQPTEPVLAILKKTGDWQKFKGEPAPAPLLVAEPKATRPSFEALGGDDEGKGEAITQKKKAEKKDEAAAESESTEA

Crispr_ID: NC_021985_12

• CRISPR_ID: NC_021985_12
• CRISPR_location: 6159276-6159496
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_021985_12

Consensus_repeat	Method
CTGCGGGAAGCCGTAACCGCCGGGGGGAGTGGGAC	PILER-CR

spacers of NC_021985_12

>12.1|6159311|37|NC_021985|PILER-CR
CGGTGGGCCCGCCGGGTGCGGCGGACCGCTGCTCGGA
>12.2|6159383|92|NC_021985|PILER-CR
GGCTGGGCCGGGGGGTTGGGCGCGCTGGGCTGCTGCGGGAAGCCGTGACCACTCGGCGGGATGGCCCCGTTCGGAACCGGCTGCTGCCCCTG

CRISPR arrays and Neighbor proteins around NC_021985_12

CRISPR arrays

The CRISPR arrays of NC_021985_12

>merge|NC_021985|12|6159276-6159496|PILER-CR
CTGCGGGAAGCCGTAGCCACCGGGGGGAGTGGGCCCGGTGGGCCCGCCGGGTGCGGCGGACCGCTGCTCGGACTGGGGGAAGCCGTAACCGCCCGGCTGGGCCGGGGGGTTGGGCGCGCTGGGCTGCTGCGGGAAGCCGTGACCACTCGGCGGGATGGCCCCGTTCGGAACCGGCTGCTGCCCCTGCTGCGGGAAGCCGTAACCGCCGGGGGGAGTGGGAC

>NC_021985|12|1|6159276-6159496|PILER-CR
CTGCGGGAAGCCGTAGCCACCGGGGGGAGTGGGCC	CGGTGGGCCCGCCGGGTGCGGCGGACCGCTGCTCGGA
CTGGGGGAAGCCGTAACCGCCCGGCTGGGCCGGGG	GGTTGGGCGCGCTGGGCTGCTGCGGGAAGCCGTGACCACTCGGCGGGATGGCCCCGTTCGGAACCGGCTGCTGCCCCTGCTGCGGGAAGCCG
TAACCGCCGGGGGGAGTGGGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_078614809.1|6147528_6150594_+|translation-initiation-factor-IF-2	unknown	unknown	gnl|CDD|235401
NC_021985.1|WP_078614810.1|6172701_6173973_+|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|274856
NC_021985.1|WP_020942567.1|6152805_6156423_+|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl|CDD|379142
NC_021985.1|WP_020942578.1|6170904_6172677_+|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NC_021985.1|WP_043479177.1|6161374_6162115_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942564.1|6150791_6151085_+|DUF503-domain-containing-protein	unknown	unknown	gnl|CDD|377364
NC_021985.1|WP_020942566.1|6151601_6152507_+|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl|CDD|235113
NC_021985.1|WP_020942575.1|6167150_6169457_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942576.1|6169468_6169939_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942560.1|6145460_6145970_+|ribosome-maturation-factor-RimP	unknown	unknown	gnl|CDD|234627
NC_021985.1|WP_043476510.1|6166614_6167154_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942568.1|6156563_6157511_+|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl|CDD|235536
NC_021985.1|WP_043479180.1|6170470_6170908_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942562.1|6147083_6147365_+|YlxR-family-protein	unknown	unknown	gnl|CDD|377288
NC_021985.1|WP_020942572.1|6163684_6165214_+|type-VII-secretion-protein-EccB	unknown	unknown	gnl|CDD|368288
NC_021985.1|WP_020942559.1|6144718_6145243_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942565.1|6151134_6151605_+|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl|CDD|234787
NC_021985.1|WP_020942573.1|6165225_6166488_+|type-VII-secretion-associated-serine-protease-mycosin	unknown	unknown	gnl|CDD|274856
NC_021985.1|WP_020942561.1|6145972_6146971_+|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl|CDD|237061
NC_021985.1|WP_193384501.1|6162150_6163488_-|type-VII-secretion-protein-EccE	unknown	unknown	gnl|CDD|274857

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_078614809.1|6147528_6150594_+|translation-initiation-factor-IF-2	gnl|CDD|235401	PRK05306, infB, translation initiation factor IF-2; Validated.	0
NC_021985.1|WP_078614810.1|6172701_6173973_+|S8-family-serine-peptidase	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	1.16117e-71
NC_021985.1|WP_020942567.1|6152805_6156423_+|trypsin-like-peptidase-domain-containing-protein	gnl|CDD|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	6.68402e-06
NC_021985.1|WP_020942564.1|6150791_6151085_+|DUF503-domain-containing-protein	gnl|CDD|377364	pfam04456, DUF503, Protein of unknown function (DUF503). Family of hypothetical bacterial proteins.	2.04391e-34
NC_021985.1|WP_020942566.1|6151601_6152507_+|tRNA-pseudouridine(55)-synthase-TruB	gnl|CDD|235113	PRK03287, truB, tRNA pseudouridine synthase B; Provisional.	1.57393e-162
NC_021985.1|WP_020942578.1|6170904_6172677_+|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	0.000483103
NC_021985.1|WP_020942560.1|6145460_6145970_+|ribosome-maturation-factor-RimP	gnl|CDD|234627	PRK00092, PRK00092, ribosome maturation protein RimP; Reviewed.	1.78949e-43
NC_021985.1|WP_020942568.1|6156563_6157511_+|bifunctional-riboflavin-kinase/FAD-synthetase	gnl|CDD|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	2.09334e-150
NC_021985.1|WP_020942562.1|6147083_6147365_+|YlxR-family-protein	gnl|CDD|377288	pfam04296, DUF448, Protein of unknown function (DUF448).	6.28541e-24
NC_021985.1|WP_020942572.1|6163684_6165214_+|type-VII-secretion-protein-EccB	gnl|CDD|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	1.34097e-66
NC_021985.1|WP_020942565.1|6151134_6151605_+|30S-ribosome-binding-factor-RbfA	gnl|CDD|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	1.1812e-49
NC_021985.1|WP_020942573.1|6165225_6166488_+|type-VII-secretion-associated-serine-protease-mycosin	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	1.40313e-92
NC_021985.1|WP_020942561.1|6145972_6146971_+|transcription-termination/antitermination-protein-NusA	gnl|CDD|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	0
NC_021985.1|WP_193384501.1|6162150_6163488_-|type-VII-secretion-protein-EccE	gnl|CDD|274857	TIGR03923, T7SS_EccE, type VII secretion protein EccE. This model represents the transmembrane protein EccB of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccE1, EccE2, etc. This model represents a conserved core region, and many members have 200 or more additional C-terminal residues. [Protein fate, Protein and peptide secretion and trafficking].	2.03354e-49

Protein sequences

>NC_021985.1|WP_020942568.1|6156563_6157511_+|bifunctional-riboflavin-kinase/FAD-synthetase
MQRWRGLEDIPQDWGRSVVTIGSYDGVHRGHQLIIRHAVDRARELGVPAVVVTFDPHPSEVVRPGSHPPLLAPHHRRAELMADLGVDAVLVLPFTTEFSKLSPADFVVKVLVDKLHAKAAVEGPNFRFGHKAAGDVEFLAEQGKIYDFEVEVVDLYVSGEAGGGQPFSSTLTRRLVTEGDVAGAREILGRPHRVEGVVVRGAQRGRELGFPTANVETLPHTAIPADGVYAGYLHAQGEIMPAAISVGTNPQFDGTERTVEAYAIDRVGLDLYGLHVAVDFLAYVRGQAKFESLEALLEQMAEDVKRCREIVASEA
>NC_021985.1|WP_020942567.1|6152805_6156423_+|trypsin-like-peptidase-domain-containing-protein
MAGPIGEADRTGAPGAVADRTQARAPGDRTHETDVVTSADACGAGAGPLPDRAEGAGPAVARARTDVLVRIHDLAGRPRGIGFLADHDGTLLTSHEAVDGLARLVLHAGPGRTCVVGADAVTALPEQDLALIRTEGLDVEPLPLTTRERVEAGTYVRIAAGCWREARVLAATQVTYTATDRFHLIEDALELAVGTAGQDALRLGGGAAGGPVLDAETGTVLGVLGTALHSARRDCGFAVPLRPADGPLAELLVRNATTVPAYGADLNLAGVLELTATSVGEDGPTFSDLGHTGATGPAHPVRPVERAGVAAELSAFTTGDRHVLGLVGAPGSGRTTELAALASRRARTGPPEPTLWLRGADLKDTDDSVADAARRALRRAARIVAASRGTHHTGLGDLTPTRVARLARQAGRPLLLLLDGPEEMPSALAHRLPAWTSGTADWLRASGARLVVACREEHWERAGAEFPADLLHGQRHGGPALPPCVPLTGLDEDEARLARARHGVPDGALTGRDARHPLTLRLFSEVRAALPDAAPTRPVDRHEVFAAHLDLVCLRVAVRLAAGNGLRGTAVRRLAARVAGQVHEAARRSLGPGQGHLDRSSFEELFPWGPAPARLGGGSGWASAVLTEGLLVPAGPGYRFAHEELADWIQGTHLDLDEALDALIHRPHPPGGTEPLPVPHHRAGPVVQSLLLLGRQQGPGALGARLRDLADALDRDPASWWAARLLGRTLLQVPDATPYTDVLRLLADHIVGRRREQRPVPAEFGPAFWTELPLPDAERCALLRRLVLADGAPPGPGDREEHAGERYLDAAARLLAADPTAVQPHLIAWFDDERPLPATPHATVATAAQALLHTHRHGALDELTEQLVRSPHPRADELLAVLAEDEPSAVCRAVDRWAHHEHPARRAAALACGLRVAAHAHTPADRELLRYAALALLARPVDRPLHGGALTLLVRDPQTRARYLAEALRHFADGDPRIPPDALIPVLTTHAGPVLEAFGARLAGGPDTGETLRALAGVTNPALTGRIAALIQETAAPRPEAAGHLAAYVDRRLDAGPTSRATLLPLVTGLADNGSERLRAALAGVLATPGAPASRALREELLDILLAHERDPDVLDAVLHAAAPHGDGRDAELRALVHRTGLLLGRTPDGATRFDWSLVVLARHVPGFAARMARWLGETPQDWAAVVGPSAHRMIENLAGVRVPA
>NC_021985.1|WP_020942566.1|6151601_6152507_+|tRNA-pseudouridine(55)-synthase-TruB
MTQKHTTPDGLVIVDKPSGFTSHDVVAKMRGIARTRRVGHAGTLDPMATGVLVLGVERATKLLGHLALTEKEYLGTVRLGQNTVTDDAEGEITSSTDASKVTRDAIDAGIAKLSGDIMQVPSKVSAIKIDGVRSYKRAREGEDFEIPARPVRVSSFAVYDVRDAVAEDGTAVLDLVVSVVCSSGTYIRALARDLGADLGVGGHLTALRRTRVGPYKLDAAKTLEQLQQELTVMPVAEAASAAFPRWDVDAKRSRLLLNGVRLEMPEEYAGTGAVAVFGPENRLLALVEEHKGKAKSLAVFG
>NC_021985.1|WP_020942565.1|6151134_6151605_+|30S-ribosome-binding-factor-RbfA
MADNARAKRLADLIREVVAQKLQRGIKDPRLGSHVTITDTRVTGDLREATVFYTVYGDDEERKEAAAGLESAKGILRSEVGRAAGVKFTPTLTFVADALPDTAKTIEDLLDKARQSDAQVREASAGAAYAGGADPYRKPADDEVADTTDTDGDAAE
>NC_021985.1|WP_020942564.1|6150791_6151085_+|DUF503-domain-containing-protein
MYVGTLSFDLLLGDVHSLKEKRSVVRPIVAELQRKYTVSAAEVDHVDLHRRAIIGLAVVSGDATHLTDVLDRCERLVAGRPEVELLSVRRRIHGDDD
>NC_021985.1|WP_078614809.1|6147528_6150594_+|translation-initiation-factor-IF-2
MAKVRVYELAKEFGVESKVVMAKLQELGEFVRSASSTIEAPVVRKLTDAFQGGSGKSAGKPAPRKAAPKPAAPAPAQAARPAAPRPAAPKPPTAPAPAAQQPAAPPAPSAPAPAQGPRPVPGPKPAPRPAPAAPEFTAPPAPAAQAPQAPAAQGPRPGARPGAPKPGGRPSGPGQGQAARPGQGGARSGGQAPRPGARPAGPRPGNNPFTSGGSTGMARPQAPRPQGGPRPGGPGAPGAGPRPQAPGQQGGGPRPQAPGGSRPSPGGMPRPQGGPRPGPAGPRPNPGMMPQRPAAGPRPGPGGGGRGPGGAGRPGGGGGRPGGGGFAGRPGGGGGGFAGRPGGPGGGGGGFAGRPGGPGGGGGGRPGFGGRPGGPGGRGGTQGAFGRPGGPARRGRKSKRQRRQEYEAMQAPSVGGVMLPRGNGETIRLSRGASLTDFAEKINANPASLVAVMMNLGEMVTATQSVSDETLQLLAGEMNYTVQIVSPEEEDRELLESFDIEFGEDEGDEEDLVVRPPVVTVMGHVDHGKTRLLDAIRKTNVIAGEAGGITQHIGAYQVATEVNDEERKITFIDTPGHEAFTAMRARGAKSTDIAILVVAANDGVMPQTVEALNHAKAADVPIVVAVNKIDVEGADPTKVRGQLTEYGLVAEEYGGDTMFVDISAKQGLHIDSLLEAVVLTADASLDLRANPHQDAQGISIESRLDRGRGAVATVLVQRGTLRVGDTMVVGDAYGRVRAMLDDNGNNVAEAGPSTPVQVLGLTNVPGAGDNFLVVDEDRTARQIAEKRAARERNAAFAKRTRRVSLEDLDKVLKAGEVQQLNLIIKGDASGSVEALESSLLQLDVGEEVDIRVLHRGVGAVTESDIDLAMGSDAIVIGFNVRAAGRAAQMAEREGVDVRYYSVIYQAIEEIEAALKGMLKPEYEEVELGTAEIREVFKSSKLGNIAGVLVRSGEVKRNTKARLIRDGKVVAENLTISGLRRFKDDVTEIREGFEGGINLGNFNDIKVDDVIATYEMREKPRV
>NC_021985.1|WP_020942562.1|6147083_6147365_+|YlxR-family-protein
MSGRTRARACPERTCVGCRQRAAKDVLLRTVADQEQCVPDPRGTLPGRGAYVHPDPVCLDQAVRRRAFPRALRVPGPLDIKALRRYVEQTDSC
>NC_021985.1|WP_020942561.1|6145972_6146971_+|transcription-termination/antitermination-protein-NusA
MDIDMSALRGLVREKEISFPLLVEAIESALLIAYHRTEGSRRHARVELNRETGHVTVWAKEDPEDLEEGQEAREFDDTPSGFGRIAATTAKQVILQRLRDAEDDATLGEYAGREGDIVTGVVQQGRDPKNVLVDIGKLEAILPVQEQVPGETYPHGMRLRSYVVRVAKGVRGPSVTLSRTHPNLVKKLFALEVPEIADGSVEISAIAREAGHRTKIAVRSTRSGLNAKGACIGPMGGRVRNVMGELNGEKIDIVDWSDDPAEMVANALSPARVSKVEVVDLASRSARVTVPDYQLSLAIGKEGQNARLAARLTGWRIDIRPDTEQAGDRDGE
>NC_021985.1|WP_020942560.1|6145460_6145970_+|ribosome-maturation-factor-RimP
MSTTQSERLRELLEPLVTSQGLDLEEIAVDSVGRKRVLRVVVDSDTGADLDAIADVSRALSAKLDETNAMGDAAYDLEVGTPGAERALTEHRHFVRATDRLVRFQLAEGGELVARILTVDEDGLDVEVPGVKGRKATTRRLGFPEIAKARVQVEFNRKDKKDMKEEEEA
>NC_021985.1|WP_020942559.1|6144718_6145243_-|hypothetical-protein
MPYSPPPRTLSGPRRRSLIASAAGAALLVGCSAAEDSGDEGPSRAARARARAARDSASLLEHYDAVAAAHPALADRLRPLRAAVAAHAEAFGGAGATRSPSPAAAGASVSATASPPAVPAAPKDALASLAAAERDLADRRARALLDVPGELARLMASVAAAGAAHAYLLTEAAK
>NC_021985.1|WP_043479177.1|6161374_6162115_-|hypothetical-protein
MRPTASGMRRMGERLRHGLGLIGPRHGRHGLPLQQLDTLALPIGDDGVVAGVDAEGQPAVLGINRPTPYDVVLIGGLWTAQVLALRTAATGARVAVETGRPQAWMQMVHAMGGGQNGLAVYEVGRVPPQGASAGTPVLVVRDCGMRPPRGRVVSGPWQSVLTLLPYLSPVAPRLLRQARLTGIQRVSPDEAAELGRTMGLSRTEVESLPGLPDGVTLWCTDRDRQYVMTQPTDAEIGLLGTPRRMD
>NC_021985.1|WP_193384501.1|6162150_6163488_-|type-VII-secretion-protein-EccE
MASGTRSRSRGRSVGRGRADASAPVPAGAASRQGTPRQPVALGLRSRPGHAGSFRLQRLVLVEIAAALLLVGWLVGPMALVPAAVVALALLLVAFVRRRGRSLPEWLSTARELKARRRRAASTPIPPGTEPALVPALECEPALRTHSYGGRDRRPVGIVGDGTFVTAVLQVEADATALRAERTRQPLPLGLVRDALEVDGIRLESAQIVLHTQPAPALHLPQQSVAVANYQPLQEQTGSPAVRITWIALKLDPELCAEAVAARGGGLTGAQKCVVRVADHLASRLTGAGFRARVLDEEELIAALATSACANPLVTAEAGRSETRERRTEESGRSWRCDNRRHTTYWVRRWPQLGGERGESLPQFVARVTAVPALATTFSLTLAQGERQEASLCGHLRVTGRSDDELVAARRALEGAARQAGAVLARLDREQLPGMLATLPLGGAR
>NC_021985.1|WP_020942572.1|6163684_6165214_+|type-VII-secretion-protein-EccB
MASRRDQLNAYTFAKRRMLASFVQSSPDTSDEGAPRPLRAVLPGAIVGVVVLAAFGAWGMFKPTAPQGWDTPATKVIIASKSTTRYVVLKTKGKAELHPVLNMASAKLVLNGQSDVDVVTVDESILDNGTIPHGVTIGIPYAPDRLPSASEAGADHTWAVCERPSGSGSSIQKAAFVLAERDRKKTEKPGQKLHGGELLYVTTVSDGKQYVVDAHGTAYPVDASDSHLVETLVGSDRKPQQVTSQWIDTLHPGDPIRFPRIEGVPNAAANAPGELGDANRVGMVLRAPVNGHEQYFVVLPGRVAPVSDFVAQLLLADTNLVKVGQAGHFREVSAGAISRDKPFASQYNWPTQEPTAVNDASTATGSRNTVCNVLHHVDPRNGDTTLTTWAGKDFPAELATDSSSAYVTPGSGQLYRQFQGRETGVGPVFLVTDTGLRYALQSNADSASENEGIGMTAKQRRQMQTEAKLAQTRLGYADVRTTPVPAPWSKFLPTGPRLSTAGASQPQGS
>NC_021985.1|WP_020942573.1|6165225_6166488_+|type-VII-secretion-associated-serine-protease-mycosin
MRSTPSTRTSLASALAVTACLLAAPAAAADPVTDQCTFSRTNHKYSGTPWSLQRVNLDELWTQSKGKGVKVAVIDTGVDTANPQLTHAVDASRGANYLPAKDGKGQPIERGNKQGTTDTVGHGTRVAGIIAARPMKGTGFVGLAPEATIIPIKQNDAEGHGTSGTLATAINHAVAAGAQVINISQDTANAVAPGGPLQNAVDEALRHKVVVVASAGNDGIDGNSKRTYPASYPGVLAVAASDRNNEKAPFSQAGDWVGVAAPGVDMISTVPKGGHCSDNGTSFSAPYVAGVAALIKAKHPRWTAQEVTAQIEQTAERSITGHDRLVGWGVVDPVRALTEDDHPIETPHADPGLTHVEAPTPARLTLGETPQERIARIATYVAVGVAVLVAAIGGGAVALRDARRRRGGRASTGSWTRRPS
>NC_021985.1|WP_043476510.1|6166614_6167154_-|hypothetical-protein
MNAASYARRGVCLFLAAVAVAGCASEKPKREFAVPGALCGVPVPTGALARLLPASGKRLTAQQRGSSDDGAALCDIRVDGDSVLIVSSERISMGDSAGHILRSRLSIQQQKSAEGDSIAYADRAAVSLVKCRGSDVQQEDISTLVKILEPARRNESAVKDLITGYTASLRKQHPCHAAS
>NC_021985.1|WP_020942575.1|6167150_6169457_-|hypothetical-protein
MALTFTDLIEVDLGKLATAVSDWKKAVEGLKKSAESARTGMQAKSDSARWAGVNATVTREFVTKTAKEVSDLHAEANSIYQVLDDGHTELLSLQNQMKAAVQNDAVSQGIRVEDIGGGKVRCFFPHVRGDTDERTQEQLDGRQALEDRINRILAHADEIDASVARALAKSHGNDRHNAGHSTYESLNDAEVERALELAHKGKKMSDAELRELNELLRFNSAEKDGEFATEFYQGLGGPEKTLQFYAEMSIDGTDAGATKTRLDEVRDLQKVMGYTLANATDPDHAHHLPDTWSADFRRLGTQQIGWEKGQWNKPYGYQVLGGLLRYGDYDPRFINPIAEHITQLHKKDPYFFLSNKPAGSPDAYGFNPSGRLGSGNDPLNSVLEALGHSPEASQKFFTTPPTAYNEDGTVKKGGDPGFTSYLDLFTDKDFEWTIDTNAANVLADEDKTKAALTFGPEALGHALESATTGRPYDSDATADAIKHTDAQAHLVSEIVDKFGGDPELIRHNENGDLEDEESGPLYALRGSLGDITAEYMGDFQQAMYQEDSGSDLFPTFGSAADLDPNHVARFLGEVGQDPDAYSAITTAQQAYTTDVVDHVINGSSHSTASMDGRVGAAVAPGSAIAGIMSDARAHAIYHYHTASDTEFNDAAAEKQKWVNRILGMGIEKVGERVPIAGAPLEWASEDIQESIMKSIEQDTTSEAETEAGEEYTNGRTAALDSAGAAVDHALTKNNTIDPDTADDLRRAARTSAGHSHSDGAQWKSESGH
>NC_021985.1|WP_020942576.1|6169468_6169939_-|hypothetical-protein
MAWDEWEQLKAHAAEQQSTRMRLNQLPADGGGAGAGAGGDLVVNQDDLGAVGHEANLLYHDVKSQADIAAGPGGGATPQAATTLKSHGFQTGGALATTVEVWSSQVNSVLQACAHISDHLDYTQKRHAEDDAKIGAVLRGSDGSTVSVSQLDEYFK
>NC_021985.1|WP_043479180.1|6170470_6170908_+|hypothetical-protein
MKRGVEVLSKFRDDINKALLKFEESPGSSSKLADHALSRPSFSGAQIPFAEAQDLHLQYEHVHTRLMHLSKTLALQIEAMTLAAHSADATYDGTEDEVRRRFWKIKTQLDAEYDKATRKDEHKAEQPAKDTRHHTDHSSAGVSTK
>NC_021985.1|WP_020942578.1|6170904_6172677_+|hypothetical-protein
MSDNWQKQPQYKTGLEQANTESVVANAVSGVKNLFRGTPLGSTHFDDAALNAMIDLVEHANPEHLEMAGKALWDARDAVGRAATDLTKNIRAVLADWEGEGADQFDTWTQSLLTYTKQLETYAHVAGTQISTAATGLASVRKSMPPRDTRPAAEQKKPSELPHAKRVDSNPDFVLAKQVEKNRQDAINQMVRLGSFYSVAAAGLQSNQEPKPIQAIPDVGVARARDGVDAQRRVISPEASTSTPASTVRRSVADGHGPTPVSHGTESGGGVPPLQQVHEPHAPAHHDVGTEINTAGTLPSTAPAAPSGPSAPTLPTAGGGGQSTPLPSGPMTPPIVPTVGRTTGYGPTSRLPISAQGRTGPSGTVRGRVPQEPEGQSGRTVTGGRSPQGPEGQAARAMGRTTPAGQSAVRGATQQTGRSPMGRSITGGTPRTSNTPGGRPGVAGPAGAARNGVVGGKPVTGRSSAGTSNTRVPRGMVVGAEEPVSATQPKGALGQRGVVGASAAKADPGTSQSVLRSASNPEGAIGAQRNAAGSKSGGPESGVRGARLGRGAVGNRQNANGETDGAGAPGEKQQHPRQQKQRREVQEKRD
>NC_021985.1|WP_078614810.1|6172701_6173973_+|S8-family-serine-peptidase
MKPGTGRRGIRDALLTGRDVRRLAAVCSALGTLVIASVGLAPGAAAEDIHSRQWYLNSMGADEMWKYSTGKGVKVAVIDSGVNAATSTLKGQVLASQVPKSVAYKATEDNDGHGTGMAEVIAGTGAGGGVKGLAPGAKIVPIHIQYSKGKYDGKLPELADAIRAAADSDAKIINMSFAGPYPDSQEEAAVKYAASKGKLMFAGIGNDGPKGKASYPATYPYVIGVSAIDKSGTVAKFSTKSNYVDFAAPGVHIPGWCDGKFTQYCDTDGTSPATALASASAALVWSVHPDWTANQVLRTLIDTAGRSWAKDEPSTYLGYGIIRPRRVLIDKNIDPGPANRDPLYAENGTDADEDVTATPSLSAAPAPGHPSKDAGSSGGPTSAAAKSSGSGGNSQTWVIIGAAAAVLIIGGAGFAVLRARRNA

Crispr_ID: NC_021985_13

• CRISPR_ID: NC_021985_13
• CRISPR_location: 6649215-6649580
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 7 spacers

Consensus repeat of NC_021985_13

Consensus_repeat	Method
ACCACCCGCGCACGACCGCCGGCAC	CRISPRCasFinder

spacers of NC_021985_13

>13.1|6649240|56|NC_021985|CRISPRCasFinder
CGGCGGCCCCGAAGGCGACACCCGCCCGCCCGGCAGGTGACCACCCGGCCGGCACG
>13.2|6649321|28|NC_021985|CRISPRCasFinder
ACGACCGCCGGCACGGCCCGCATGCGCC
>13.3|6649374|15|NC_021985|CRISPRCasFinder
GCCCCCCCATGCGCC
>13.4|6649414|15|NC_021985|CRISPRCasFinder
ACGACCGCCGGCACA
>13.5|6649454|16|NC_021985|CRISPRCasFinder
ATGACTGCTGGCATGG
>13.6|6649495|17|NC_021985|CRISPRCasFinder
ACCACGGCCCGCACATC
>13.7|6649537|19|NC_021985|CRISPRCasFinder
GGCCCCCCCACGCCCCGCC

CRISPR arrays and Neighbor proteins around NC_021985_13

CRISPR arrays

The CRISPR arrays of NC_021985_13

>merge|NC_021985|13|6649215-6649580|CRISPRCasFinder
ACCACGCGCACAAGGACCACGGCGCCGGCGGCCCCGAAGGCGACACCCGCCCGCCCGGCAGGTGACCACCCGGCCGGCACGGCCACCCGCGCCCCACCGCCCACGCACGACCGCCGGCACGGCCCGCATGCGCCACCACCCGCGCACGACCGCCGGCACGCCCCCCCATGCGCCACCACCCGCGCACGACCGCCCGCGCACGACCGCCGGCACAGCCAACCGCGCACCGTCGCCCGCGCATGACTGCTGGCATGGCCACCCCGCGCACCACCACCCGCGCACCACGGCCCGCACATCACCGGCCACGCACGACCGCCAACACGGCCCCCCCACGCCCCGCCGCCACCGACGCGTCGTCGCCGGCAC

>NC_021985|13|12|6649215-6649580|CRISPRCasFinder
ACCACGCGCACAAGGACCACGGCGC	CGGCGGCCCCGAAGGCGACACCCGCCCGCCCGGCAGGTGACCACCCGGCCGGCACG
GCCACCCGCGCCCCACCGCCCACGC	ACGACCGCCGGCACGGCCCGCATGCGCC
ACCACCCGCGCACGACCGCCGGCAC	GCCCCCCCATGCGCC
ACCACCCGCGCACGACCGCCCGCGC	ACGACCGCCGGCACA
GCCAACCGCGCACCGTCGCCCGCGC	ATGACTGCTGGCATGG
CCACCCCGCGCACCACCACCCGCGC	ACCACGGCCCGCACATC
ACCGGCCACGCACGACCGCCAACAC	GGCCCCCCCACGCCCCGCC
GCCACCGACGCGTCGTCGCCGGCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_043479305.1|6651967_6652999_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942973.1|6655068_6655254_-|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NC_021985.1|WP_043476625.1|6646335_6647973_-|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|183199
NC_021985.1|WP_020942968.1|6650746_6651436_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197666
NC_021985.1|WP_043479307.1|6657252_6657477_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043476631.1|6655250_6656075_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
NC_021985.1|WP_020942960.1|6640208_6640391_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942971.1|6653066_6653945_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_021985.1|WP_193384509.1|6644667_6645987_-|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|225822
NC_021985.1|WP_020942961.1|6640387_6642088_-|nitrite/sulfite-reductase	unknown	unknown	gnl|CDD|223233
NC_021985.1|WP_020942957.1|6637991_6638933_-|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl|CDD|235375
NC_021985.1|WP_020942975.1|6656353_6657217_+|isocitrate-lyase/PEP-mutase-family-protein	unknown	unknown	gnl|CDD|119340
NC_021985.1|WP_020942958.1|6638929_6639496_-|adenylyl-sulfate-kinase	unknown	unknown	gnl|CDD|238985
NC_021985.1|WP_020942967.1|6649755_6650736_+|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|378976
NC_021985.1|WP_043479303.1|6651415_6651820_-|VOC-family-protein	unknown	unknown	gnl|CDD|319901
NC_021985.1|WP_020942972.1|6654430_6655060_-|VOC-family-protein	unknown	unknown	gnl|CDD|379203
NC_021985.1|WP_020942963.1|6643100_6644444_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020942956.1|6636654_6637989_-|sulfate-adenylyltransferase	unknown	unknown	gnl|CDD|180120
NC_021985.1|WP_020942962.1|6642449_6643022_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_021985.1|WP_020942959.1|6639492_6640212_-|phosphoadenylyl-sulfate-reductase	unknown	unknown	gnl|CDD|234997

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020942973.1|6655068_6655254_-|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	3.27503e-22
NC_021985.1|WP_043476625.1|6646335_6647973_-|acyl-CoA-dehydrogenase-family-protein	gnl|CDD|183199	PRK11561, PRK11561, isovaleryl CoA dehydrogenase; Provisional.	2.70735e-175
NC_021985.1|WP_020942968.1|6650746_6651436_+|helix-turn-helix-domain-containing-protein	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	3.78788e-12
NC_021985.1|WP_043476631.1|6655250_6656075_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	4.6379e-05
NC_021985.1|WP_020942971.1|6653066_6653945_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.25179e-08
NC_021985.1|WP_193384509.1|6644667_6645987_-|GAF-domain-containing-protein	gnl|CDD|225822	COG3284, AcoR, Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription].	2.03182e-32
NC_021985.1|WP_020942961.1|6640387_6642088_-|nitrite/sulfite-reductase	gnl|CDD|223233	COG0155, CysI, Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism].	2.80598e-174
NC_021985.1|WP_020942957.1|6637991_6638933_-|sulfate-adenylyltransferase-subunit-CysD	gnl|CDD|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
NC_021985.1|WP_020942975.1|6656353_6657217_+|isocitrate-lyase/PEP-mutase-family-protein	gnl|CDD|119340	cd00377, ICL_PEPM, Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate lyase (ICL), and 2-methylisocitrate lyase (MICL). Isocitrate lyase (ICL) catalyzes the conversion of isocitrate to succinate and glyoxylate, the first committed step in the glyoxylate pathway. This carbon-conserving pathway is present in most prokaryotes, lower eukaryotes and plants, but has not been observed in vertebrates. PEP mutase (PEPM) turns phosphoenolpyruvate (PEP) into phosphonopyruvate (P-pyr), an important intermediate in the formation of organophosphonates, which function as antibiotics or play a role in pathogenesis or signaling. P-pyr can be hydrolyzed by phosphonopyruvate hydrolase (PPH) to from pyruvate and phosphate. Oxaloacetate acetylhydrolase (OAH) catalyzes the hydrolytic cleavage of oxaloacetate to form acetate and oxalate, an important pathway to produce oxalate in filamentous fungi. 2-methylisocitrate lyase (MICL) cleaves 2-methylisocitrate to pyruvate and succinate, part of the methylcitrate cycle for the alpha-oxidation of propionate.	9.72532e-59
NC_021985.1|WP_020942958.1|6638929_6639496_-|adenylyl-sulfate-kinase	gnl|CDD|238985	cd02027, APSK, Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of inorganic sulfate.	1.26522e-81
NC_021985.1|WP_020942967.1|6649755_6650736_+|AraC-family-transcriptional-regulator	gnl|CDD|378976	pfam12852, Cupin_6, Cupin. This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.	9.56468e-45
NC_021985.1|WP_043479303.1|6651415_6651820_-|VOC-family-protein	gnl|CDD|319901	cd07235, MRD, Mitomycin C resistance protein (MRD). Mitomycin C (MC) is a naturally occurring antibiotic, and antitumor agent used in the treatment of cancer. Its antitumor activity is exerted primarily through monofunctional and bifunctional alkylation of DNA. MRD binds to MC and functions as a component of the MC exporting system. MC is bound to MRD by a stacking interaction between a His and a Trp. MRD adopts a structural fold similar to bleomycin resistance protein, glyoxalase I, and extradiol dioxygenases; and it has binding sites at an identical location to binding sites in these evolutionarily related enzymes.	4.31617e-57
NC_021985.1|WP_020942972.1|6654430_6655060_-|VOC-family-protein	gnl|CDD|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	2.07467e-46
NC_021985.1|WP_020942956.1|6636654_6637989_-|sulfate-adenylyltransferase	gnl|CDD|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
NC_021985.1|WP_020942962.1|6642449_6643022_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.11223e-08
NC_021985.1|WP_020942959.1|6639492_6640212_-|phosphoadenylyl-sulfate-reductase	gnl|CDD|234997	PRK02090, PRK02090, phosphoadenylyl-sulfate reductase.	6.10085e-112

Protein sequences

>NC_021985.1|WP_043476625.1|6646335_6647973_-|acyl-CoA-dehydrogenase-family-protein
MAGNSTHTVTNQPPPLVAYDVFTADRALVEAVERHTAADTLDEVRAELAALGTSAGAAQVQEWGALANEYPPRLRTHDRYGHRIDRVEFHPAWHRMLGKGVSAGLTAAWTRPAGHVRRAAGFLVWTQVEAGTCCPLSMTHAAVPALRADPELAAEWEPLLTSTIYDQDLRPAASKAGALFGMGMTEKQGGSDVRTNTTGARPLAEAGTYALTGHKWFCSAPMSDGFLVLAQAPDGLTCFLVPRVLPDGTLNTFLIQRLKDKLGNRSNASAEVEFDGTWARRVGEEGRGVRTIIEMVAATRLDCALGSAGLMRQAVAQAVHHCAHREAFGGKLIDKPLMRNVLADLALESEAATALALRLAAAHDDGGEQELALLRLAVPAAKYWITKRCAPLAVEAAECLGGNGYVEESGLPRLVRESPLNSIWEGAGNVQALDVLRALRREPGALDACLTEIGRAHGADHRLDRAVKDLFTELAHLDGVEARARRLVERLALVLQGSLLVRYAPPAVADAFCASRLGGDRGAAFGTLPSGLDLASVVERARPVP
>NC_021985.1|WP_193384509.1|6644667_6645987_-|GAF-domain-containing-protein
MPFPGRTPVVNPPVNVARLAAVDAAQAARVLHQVREATLSGRRARIAPRPVIEQSWGRMLRGGVDPDRDVRSRPLSAEEVRRRREESPLGRVLPVLRQGLLSVADADAHIMVVADAEGRVLWREGSPAVLRKADGLGFELGADWREDVVGTNGVGTAAVVRRPVQVFAGEHFVRTHTSWTCAGAPITDPRDGSLLGVVDVSGPLETMHPATLAWVDAVARLAEARLRELHRDSLEGLRAVAAPILARLDGGALAVDRDGWTAAVTGMPYVRRVSLPRSLTPGAHRLPALGTCAVEPLAGGWLLRAAEEPPPATGLRVELDLGRAGRTSVTVTGTAGSWSRELSPRHAELLYLLAEHRTGRGAAALAEDLFGDPSRTVTVRAEMSRIRRYLGEVLRHRPYRFREDAEVEVLLPEDPRDLLPRSTAPAVARRRATAGAGAG
>NC_021985.1|WP_020942963.1|6643100_6644444_-|hypothetical-protein
MKQRGRHRRRRRGAALRAVLAGAALALTATATLISASQATVAANPGALRPLTSRADTAPLRLREHLVPARTLNRLAASMGRPVGVDAVLRSADRSLRQGAGCGSEDRETLPVAPAVTRAYCWDRADTADTAWQPASVTTSGDADDDGVWGSHRVILTGWTHDTATGPAAERGLARVAFVDADDPRHPVYRWVLLVVPVEGGRDYRALASGVSGMVWYQDKLLVTTRGGSADALYVYDLDRIQRTTADRAAIGRVHGGWSGGGYRYVMPAVGSYRFTAGRCGASGPPCPAGLSLDRGTAPDSLVAAEWTAPGSERRARLWRYAFSTDPAREGLLATGAAGRVDPVEAYRTRATGIRGVLSYRRPGAAGPSWYVGHVSANGGDTDGHGGLWRQDRKGAKADRCGSDASHRCWAQGPGALSYWQETGEVWSLSRRMLFALPLAALDRTLD
>NC_021985.1|WP_020942962.1|6642449_6643022_-|GNAT-family-N-acetyltransferase
MSSAPVTTWSLEQTSPADLLPAAAPDGDVRIVRAEVPSPEFSRFLYASVGGDIRWTDRLGWDYARWQRQLDRPGVETWVAYDRGTPAGYVELEPQDDGAVEIVYFGLIPAFRGRRIGGHLLSYGAARAWDLAERWAELTPTKRVWLHTCSKDGEFAMDNYLRRGFTLFDTKVEVEAVVATPGPWPGAYPA
>NC_021985.1|WP_020942961.1|6640387_6642088_-|nitrite/sulfite-reductase
MAATPQNPAASAPRRKVSRHRGEGQWAAGHFTPLNGNEQVKKDDDGLNVRTRIETIYSKRGFDSIDPSDLRGRMRWWGLYTQRKPGIDGGKTAVLEPEELDDEYFMLRVRIDGGALTTRQLRVIGEISQEFARGTADITDRQNVQYHWIRIEDVPAIWERLEGVGLSTVTACGDTPRVMIGSPVAGIAEDEIIDATPALEEMKRRVLNNKAYSNLPRKFKTAISGSPVLDVVHEINDVAFVGVRHPEHGPGFDVWVGGGLSTNPKLGVRLGAWVPLDEVPDVYEGVISIFRDYGYRRLRNRARLKFLVADWGAEKFRRVLEDEYLGGRRLIDGPAPEQPVQQWRDHVGVHRQLDGRYYVGFAPRVGRVDGTTLTKVAELAEAHGSGRVRTTVEQKMIILDVAEEQVDSLVEGLEALDLTARPSSFRRGTMACTGIEFCKLAIVETKERGSQLIDELERRLPDFDQPITINLNGCPNACARIQVADIGLKGQLVLGDDGEQVEGYQVHLGGALGLEAGFGRKVRGLKVTSKELPDYIERVLKRYQAEREDGERFATWAARASEEALS
>NC_021985.1|WP_020942960.1|6640208_6640391_-|hypothetical-protein
MSERAAPFHCPYCGDEDLRPGEQGHGAWECGACNRAFQLKFLGLLARGLRRADNGGDDSI
>NC_021985.1|WP_020942959.1|6639492_6640212_-|phosphoadenylyl-sulfate-reductase
MTTAQSERTDEELKALAEQAGRDLEDAPALEILRWAVDTFGARFCVTSSMEDAVVAHLASRVRREDAPVDVVFLDTGYHFPETIGTRDAVEAVMDVNVITLTPRQTVAEQDAQYGPKLHDRDPDLCCRLRKVQPLEEGLKGYLAWATGLRRDESPTRANTPVVGWDEKRRKVKISPIARWTQDDVDAYVAEHGVLTNPLLTDGYPSIGCAPCTRRVLEGEDARAGRWAGRAKTECGLHG
>NC_021985.1|WP_020942958.1|6638929_6639496_-|adenylyl-sulfate-kinase
MRTDQTQENHVTTGATVWLTGLPSAGKTTIAHELAARLREEGRRTEVLDGDEIREFLSAGLGFSREDRHTNVQRIGFVAELLARNGVTALVPVIAPYADSRDAVRKRHEGNGTPYLEVHVATPVEVCSVRDVKGLYAKQAAGELSGLTGVDDPYEEPETPELRIESQHQSVQESAAAVYALLSERGLA
>NC_021985.1|WP_020942957.1|6637991_6638933_-|sulfate-adenylyltransferase-subunit-CysD
MTTVAKTATGEGTAGPYALSHLDALESEAVHIFREVAGEFENPVILFSGGKDSILMLHLALKAFAPAAIPFSLLHVDTGHNFPEVLEYRDRVVDAHGLRLHVASVQDYIDRGVLKERPDGTRNPLQTLPLTEKIQSGKFDAVFGGGRRDEEKARAKERVFSLRDEFSQWDPRRQRPELWNLYNGRHAPGEHVRVFPLSNWTELDVWQYIAREGIELPQIYFAHERDVFARGGMWLTAGEWGGPKDGETVERRLVRYRTVGDMSCTGAVDSDATTLDAVIAEIAASRLTERGATRADDKLSEAAMEDRKREGYF
>NC_021985.1|WP_020942956.1|6636654_6637989_-|sulfate-adenylyltransferase
MSTTTTEALPATTLLRFATAGSVDDGKSTLVGRLLHDSKSVLTDQLEAVERASASRGQEGPDLALLTDGLRAEREQGITIDVAYRYFATPRRRFILADTPGHVQYTRNMVTGASTAELTVILVDARNGVVEQTRRHAAIAALLRVPHVVLAVNKMDLVAYEEPVFAAIAEEFTAYATELGVPEVTAIPISALAGDNVVEPSANMDWYGGPTVLEHLETVPVSHDLAHCHARLPVQFVIRPQTADHPDYRGYAGQIAAGTFRVGEAVTVLPSGRTTRISGIDLLGEPVDTAWTTQSVTVLLEDDIDVSRGDLIVPTKDAPPTTQDVEATVCHVADQPLTVGHRVLLKHGTRTVKAIVKDIPSRLTLDDLSLHPHPGRLAANDIGRVKIRTAEPLPVDAYADSRRTGSFILIDPSDGTTLTAGMVGESFASPEPVKDAAEDDGWDF
>NC_021985.1|WP_020942967.1|6649755_6650736_+|AraC-family-transcriptional-regulator
MDAPPGPVTPSRGDPLASLLDGPRARGAFMIRACFEPPWAVRVEDRAPLTVMLMARGDAWITHDADGDGEPVRLRPGDLAITRGPAPYTCADAPGTAPQALILPGGACHHPDGRPLNGSMDLGVRTWGDRPDAPTVMLIGTYLVRGEISGRLLDALPPLLTLPAETWPSPLVPLLMDEVVRDEPGQEVVLDRLLDLLVISALRAWFSRPGAAAPGWYGALADPVVGRALRLIQDDPAHPWTVSALAAKAGVSRAALARRFTELVGEPPMTHLTAWRLALAADRLRDTDDTLAAIARQVGYGSAFALSSAFKRVYGVSPQEHRARAA
>NC_021985.1|WP_020942968.1|6650746_6651436_+|helix-turn-helix-domain-containing-protein
MYQERPSRLTGAVVWWRTPEDPAVRPVLPDGCMDLLYSEGRLLVAGPDTRAHVPAGPPRAWAGVRFHPGTAPTLLGVPAHELRDTRAELTDLWPADRVRRLRDRLAAASDPATALEDIALDLAARAAPPDPLLRLLVERLDAGRPVAATADELGIGARQLHRRSLTAFGYGPKTLARILRLRRALALARSGVPYAETAARAGYADQPHLARDVRELAGTTLGALLGPGG
>NC_021985.1|WP_043479303.1|6651415_6651820_-|VOC-family-protein
MTPRFAVIGVVASDLAASLAFYRRLGLVFPDGAEEQPHVEAELPGELVLALDTEATVRSFHPEWRAPAGGGRVALAFRCGSPGEVDAVYEDLVGAGYHGELKPWDAFWGQRYATVHDPDGNGVDLFAPLAAGAE
>NC_021985.1|WP_043479305.1|6651967_6652999_+|hypothetical-protein
MFVCGECGTELTAPVTRVAFPVRAHHHYGHEMLPALMEPGTYAVDPEPRGGPWRPWAEVGEEAAAALGVFAPVHSLPSGPPGAVVVAPGDTRATVFIAGRCDGYCLGLDGRDGPNLACESCGRAVATRMDDCSIWQAVWLDPTAVRRVPGPEPRTADWTTLLAEERGTPPVEQPGRWSPQWEASAGAALAHLLAASAGEPVALPAGLLSDMFGRALTLLLPPGRPARTLSLAGPGLPVPTGAEIVVVPVHPRTGDPWRPPGEPATVPLPLDVWLGLAFPQDRSLLPVTGGLPRDVRRDDPLPAHPNWMFRPDRWVFLRTLARLPEVRRPWLRAVYDRLRDERC
>NC_021985.1|WP_020942971.1|6653066_6653945_-|GNAT-family-N-acetyltransferase
MSLRITPLTDPTCGPHGRRLAWLASDADSIPAGTAFLRLLDGGQEHLAELDLCVHPAERRKGVGSRLLDTAVTTARDNARRRVVAQAEAGSPGDRFLAARGFRKVLTFRYTRLAMAEVDTTVLAGIVERPHPGYRLTSWQGTVPDDLAQTFAASRRAMDDMPMDDAEYGTVAWDVDRVRAAAKAVEQRGDHLHTVVAIDASNGSIAAFTELVIPGNGAGDGQHYGTGVLPEHRGHGLGRWMKAESIRQAHRDYPDLDGLLTDTADSNAHMRRINDGLGYTPTHTTHQHQLDL
>NC_021985.1|WP_020942972.1|6654430_6655060_-|VOC-family-protein
MGRIPPLLDHLVLATPELAATVAEFERRTGVTPAPGGVHVGLGTRNHLVSLGGRSYLEIIGPDPEQPEPVELRPFGVDRLAGPRTVTWAISPADLDATVSGARERGHDPGPVHPMSRRTPDGTLLRWRLTDSGTAPHGGLVPFLIDWGDSVHPTGSGLPVTPLLEVRATAPDPAGVRLALAALGTELPVSEGPFALSFTVETPRGPVTF
>NC_021985.1|WP_020942973.1|6655068_6655254_-|DUF397-domain-containing-protein
MSGTALKWVKSSYSGDEGGNCVEVASEPTSVRVRDSKTPASPHLTVTPAAWAAFLKLPGRG
>NC_021985.1|WP_043476631.1|6655250_6656075_-|helix-turn-helix-transcriptional-regulator
MGTTRRARKNASALKMVGALLALHREAAGYTQSALGQRSVLGEEMIASIEQGRRPLKPDVAEQLDELLDTKGTLSVAVSRMPEVDLVPMWAEEFLDQEREAIAISSYENQVVPGLLQTEAYAEAVFRSRVPVYPDDGVVQLVQARIDRRAILHRRQPPITCFVIWEPVVRAPIGGRDVWTEQLRHLLACSELPGLMLQVLPLERVTHAGLNGPFVLLETPEHQRLAYVETQRGSQLIADPDEVGILTQKCAMLRSQALTPEDTRELLDRLLGER
>NC_021985.1|WP_020942975.1|6656353_6657217_+|isocitrate-lyase/PEP-mutase-family-protein
MSYGNKLRERIAGPGTTPLIGVYDMYSASIAAKHYDGMFVSGFGFAASYYGLPDIGFIAWPDMVAFVQRLRGAFPHHHLLVDIDDGYVDPEVACHVVEGLERIGASGVILEDQKRPRRCGHADGKQVLPLDEYLEKLEKVLQTRKDLVVVARTDATDEHDILHRAERLAATDADVVLVDGVRSVEWIGRIREVVGTKPLLFNQIAGGKSPRLSLGELSDLGVDVAIYSTPCLFAAHEAMNSALVDLKAADGRLPRLDPSAGVGVKASTSLLERNIAPERLQPEGVGV
>NC_021985.1|WP_043479307.1|6657252_6657477_+|hypothetical-protein
MIAAALLGAAAVPAAAGGGSLVTVIDNSHADSILEVDRTANVQTGSGTAGSDHDGSAVDAIQAMLGERPSDGED

Crispr_ID: NC_021985_14

• CRISPR_ID: NC_021985_14
• CRISPR_location: 6732786-6733150
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 6 spacers

Consensus repeat of NC_021985_14

Consensus_repeat	Method
CCGCCGGGCNCCGCCGCACCGCC	CRT
GCGCCGCCGGGCGCCGCCGCACCGCCGGGCATGGCCGTG	PILER-CR

spacers of NC_021985_14

>14.1|6732809|30|NC_021985|CRT
GTGCACGGGGCACCATCGCGCGGCCATGCA
>14.2|6732862|20|NC_021985|CRT
GGGTATCGAGCACGGCCGCG
>14.3|6732905|30|NC_021985|CRT
ATGCACGGGGCACCATCGCGGGGCCATGCA
>14.4|6732958|54|NC_021985|CRT
GGGCATGGCCGTGCGCCAGGCATCGCCGCGCCGCGGGTACCGGGCACGGCCCTG
>14.5|6733035|33|NC_021985|CRT
CCGCCGCACCGCCGGGTACCGGGCATCGCCGCG
>14.6|6733091|37|NC_021985|CRT
GGGCATGGCCGTGCGCCAGGCATCGCCGCACCGCCGT
>14.7|6732971|38|NC_021985|PILER-CR
CGCCAGGCATCGCCGCGCCGCGGGTACCGGGCACGGCC
>14.8|6733048|36|NC_021985|PILER-CR
GGGCGCCCGCCGCACCGCCGGGTACCGGGCATCGCC

CRISPR arrays and Neighbor proteins around NC_021985_14

CRISPR arrays

The CRISPR arrays of NC_021985_14

>merge|NC_021985|14|6732786-6733150|CRT,PILER-CR
CGCCGCCGCACCGCCGCACCGCCGTGCACGGGGCACCATCGCGCGGCCATGCACCGCCGGTCACCGCCGCACCGCCGGGTATCGAGCACGGCCGCGCCGCCGGGTACCGCCGCACCGCCATGCACGGGGCACCATCGCGGGGCCATGCACCGCCGGGCGCCGCCGCACCGCCGGGCATGGCCGTGCGCCAGGCATCGCCGCGCCGCGGGTACCGGGCACGGCCCTGCCGCCGGGCGCCGCCGCGGGCGCCCGCCGCACCGCCGGGTACCGGGCATCGCCGCGCCGCCGGGCACCGCCGCACCGCCGGGCATGGCCGTGCGCCAGGCATCGCCGCACCGCCGTGCACGGGGCGCCGCCGCGCGGCC

>NC_021985|14|1|6732786-6733150|CRT
CGCCGCCGCACCGCCGCACCGCC	GTGCACGGGGCACCATCGCGCGGCCATGCA
CCGCCGGTCACCGCCGCACCGCC	GGGTATCGAGCACGGCCGCG
CCGCCGGGTACCGCCGCACCGCC	ATGCACGGGGCACCATCGCGGGGCCATGCA
CCGCCGGGCGCCGCCGCACCGCC	GGGCATGGCCGTGCGCCAGGCATCGCCGCGCCGCGGGTACCGGGCACGGCCCTG
CCGCCGGGCGCCGCCGCGGGCGC	CCGCCGCACCGCCGGGTACCGGGCATCGCCGCG
CCGCCGGGCACCGCCGCACCGCC	GGGCATGGCCGTGCGCCAGGCATCGCCGCACCGCCGT
GCACGGGGCGCCGCCGCGCGGCC

>NC_021985|14|2|6732932-6733103|PILER-CR
GCACCGCCGGGCGCCGCCGCACCGCCGGGCATGGCCGTG	CGCCAGGCATCGCCGCGCCGCGGGTACCGGGCACGGCC
CTGCCGCCGGGCGCCGCCGCGGGCGCCCGCCGCACCGCC	GGGTACCGGGCATCGCCGCGCCGCCGGGCACCGCCG
CACCGCCGGGCATGGCCGTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_148305756.1|6727027_6727297_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043479331.1|6718838_6719660_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020943032.1|6731424_6732462_-|polyphosphate-kinase-2-family-protein	unknown	unknown	gnl|CDD|274737
NC_021985.1|WP_020943033.1|6733220_6734087_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176106
NC_021985.1|WP_020943028.1|6725906_6726965_+|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NC_021985.1|WP_020943040.1|6742860_6743760_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NC_021985.1|WP_043476645.1|6734469_6735258_-|serine-protease	unknown	unknown	gnl|CDD|238113
NC_021985.1|WP_020943037.1|6738485_6739328_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197715
NC_021985.1|WP_020943031.1|6728652_6731385_-|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl|CDD|319775
NC_021985.1|WP_020943041.1|6743978_6745766_+|glyoxylate-carboligase	unknown	unknown	gnl|CDD|183066
NC_021985.1|WP_020943042.1|6745863_6746436_-|TIGR04222-domain-containing-membrane-protein	unknown	unknown	unknown
NC_021985.1|WP_020943025.1|6721469_6723731_+|cache-domain-containing-protein	unknown	unknown	gnl|CDD|376363
NC_021985.1|WP_020943038.1|6739545_6741219_+|AMP-binding-protein	unknown	unknown	gnl|CDD|341278
NC_021985.1|WP_020943039.1|6741215_6742853_+|AMP-binding-protein	unknown	unknown	gnl|CDD|236236
NC_021985.1|WP_020943030.1|6727702_6728548_-|patatin-like-phospholipase-family-protein	unknown	unknown	gnl|CDD|224666
NC_021985.1|WP_020943034.1|6734187_6734370_+|4-oxalocrotonate-tautomerase-family-protein	unknown	unknown	gnl|CDD|224853
NC_021985.1|WP_052352198.1|6719872_6721057_+|CapA-family-protein	unknown	unknown	gnl|CDD|378215
NC_021985.1|WP_020943026.1|6723737_6725390_+|poly-gamma-glutamate-synthase-PgsB	unknown	unknown	gnl|CDD|188527
NC_021985.1|WP_020943027.1|6725386_6725869_+|poly-gamma-glutamate-biosynthesis-protein-PgsC/CapC	unknown	unknown	gnl|CDD|379469
NC_021985.1|WP_020943036.1|6735464_6738311_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|226415

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020943037.1|6738485_6739328_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	7.80816e-14
NC_021985.1|WP_043476645.1|6734469_6735258_-|serine-protease	gnl|CDD|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	7.18788e-75
NC_021985.1|WP_020943033.1|6733220_6734087_+|LysR-family-transcriptional-regulator	gnl|CDD|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.41449e-39
NC_021985.1|WP_020943028.1|6725906_6726965_+|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.30562e-06
NC_021985.1|WP_020943040.1|6742860_6743760_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	1.59125e-13
NC_021985.1|WP_020943032.1|6731424_6732462_-|polyphosphate-kinase-2-family-protein	gnl|CDD|274737	TIGR03709, PPK2_rel_1, polyphosphate:nucleotide phosphotransferase, PPK2 family. Members of this protein family belong to the polyphosphate kinase 2 (PPK2) family, which is not related in sequence to PPK1. While PPK1 tends to act in the biosynthesis of polyphosphate, or poly(P), members of the PPK2 family tend to use the terminal phosphate of poly(P) to regenerate ATP or GTP from the corresponding nucleoside diphosphate, or ADP from AMP as is the case with polyphosphate:AMP phosphotransferase (PAP). Members of this protein family most likely transfer the terminal phosphate between poly(P) and some nucleotide, but it is not clear which. [Central intermediary metabolism, Phosphorus compounds].	9.82276e-140
NC_021985.1|WP_020943041.1|6743978_6745766_+|glyoxylate-carboligase	gnl|CDD|183066	PRK11269, PRK11269, glyoxylate carboligase; Provisional.	0
NC_021985.1|WP_020943025.1|6721469_6723731_+|cache-domain-containing-protein	gnl|CDD|376363	pfam00672, HAMP, HAMP domain.	2.20313e-05
NC_021985.1|WP_020943038.1|6739545_6741219_+|AMP-binding-protein	gnl|CDD|341278	cd05974, MACS_like_1, Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS). MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.	0
NC_021985.1|WP_020943039.1|6741215_6742853_+|AMP-binding-protein	gnl|CDD|236236	PRK08315, PRK08315, AMP-binding domain protein; Validated.	0
NC_021985.1|WP_020943030.1|6727702_6728548_-|patatin-like-phospholipase-family-protein	gnl|CDD|224666	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only].	9.41262e-26
NC_021985.1|WP_020943034.1|6734187_6734370_+|4-oxalocrotonate-tautomerase-family-protein	gnl|CDD|224853	COG1942, COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only].	1.72664e-15
NC_021985.1|WP_052352198.1|6719872_6721057_+|CapA-family-protein	gnl|CDD|378215	pfam09587, PGA_cap, Bacterial capsule synthesis protein PGA_cap. This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.	3.37907e-79
NC_021985.1|WP_020943026.1|6723737_6725390_+|poly-gamma-glutamate-synthase-PgsB	gnl|CDD|188527	TIGR04012, poly_gGlu_PgsB, poly-gamma-glutamate synthase PgsB/CapB. Of four genes commonly found to be involved in biosynthesis and export of poly-gamma-glutamate, pgsB(capB) and pgsC(capC) are found to be involved in the synthesis per se. Members of this family are designated PgsB, a nomeclature that covers both cases in which the poly-gamma-glutamate is secreted and those in which it is retained to form capsular material.PgsB has been shown to have poly-gamma-glutamate activity by itself but is bound tightly by PgsC (TIGR04011). [Cell envelope, Other].	1.21048e-126
NC_021985.1|WP_020943027.1|6725386_6725869_+|poly-gamma-glutamate-biosynthesis-protein-PgsC/CapC	gnl|CDD|379469	pfam14102, Caps_synth_CapC, Capsule biosynthesis CapC. This family of proteins play a role in capsule biosynthesis. They are essential for gamma-polyglutamic acid (PGA) production.	3.69336e-24
NC_021985.1|WP_020943036.1|6735464_6738311_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	2.98681e-19
NC_021985.1|WP_020943031.1|6728652_6731385_-|HAD-IC-family-P-type-ATPase	gnl|CDD|319775	cd02080, P-type_ATPase_cation, P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase. This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0

Protein sequences

>NC_021985.1|WP_020943032.1|6731424_6732462_-|polyphosphate-kinase-2-family-protein
MSDDRAARVAEFVAPLRVAPGARVDLARDFDPSWKAGLRKRDAAELLRSGVALLAEYQERLAAQDTYGVLLCLQALDAGGKDGTIRHVMSGVNPQGVRVSSFKVPSAEELDHDYLWRYARRLPRRGEIAIFNRSHYEEVLVVRVHPENLVRQRLPERARGPGVWDRRHREINEWEHYLTDNGFKVVKVFLNLSREEQRVRFLKRIDLPEKNWKFSASDVRERRHWDEYQRAFSEMLSATSTEWAPWYVVPADRKWVARVCTSAVLAHTLMDIDPRYPDVGEEARRELLAAREDLEREAPTGAAADPYAARHTPADPAGAAGPERRDGGEQGGRRGGKHGAKHGRR
>NC_021985.1|WP_020943031.1|6728652_6731385_-|HAD-IC-family-P-type-ATPase
MTVRSDSAERGSDSSQGARRPWYTVPAPEVVAALGVDPAAGLTAARAAELLAAHGPNALPEERRTPAWRRFLAQYRSYMQLVLVAAAAVSLGIGEWTTAVLLLVLTLLNAVVGLRQEGKAESAMNALKSMLEATARVRRDGVEAELPADRLVVGDVVLIAAGDQVPADGRVIEASALQIDESALTGESVPAAKDTGAVSGDRLPPGDQTCMAFMNTPITHGSGVLVVTATGEDTELGKISGMLSATGKEVPPLTRELDSLTLWITGAAGLTMIVMFALGRGRGQPWDTLFVSAVSLAIAAIPEALPTVTQAILSVGSLNLAKRNAIVKELPSVETLAFTSAINSDKTGTLTMNQMTAVEVLTPTDRYTVSGTGYGLEGRIHHAAGTAPGIEDAILPYAMASDATLVDGAVVGDPTEGALLVLAHKAGLDVDASRDRLPRLATLPFDPSYKLMATFHAAVDAAGRPVVRCFVKGAAPAVTARAADALVPDGTVPWDAELRERAEAQTRRMGGEGLRVMAAATRDLDPAAFDPEGDLLAHVTGLRVTSLVGMVDPPRAESRDAVADARAAQIRVRLVTGDDVTTGAAIARQIGIPGEAVLGADFAALSEEERLARIDTVGVVGRVAPEHKVLLADTLKKKGDVVAMTGDGVNDAPAIKAADIGIAMGSGTDVAKNAGRMILSDDNFATIVYAVEQGRTIYDNLTKYIRFVLLLLVTFVLTFLGATVLNIAAGEPFTPPQVLWIHFVVNASFGFALGFDRESPGLMRRRPRPRGESVLTRPVLVTVGLGGLAITVVLLGMIRLGQAVFGSVAIGQSVAFTAFALCLIVAAFECRSETESVLTPATFDSRQMNWVALAQFALAVFVTQLDGLRRLLGTTRIDARQFGWALLSAVVLLLLWELGKLLARRARHAR
>NC_021985.1|WP_020943030.1|6727702_6728548_-|patatin-like-phospholipase-family-protein
MTEALVLGGGGVGGIAWLTGVLAGLAERGRDVTGAGLLLGTSAGATVAAQLGSGLGLEELYARQVDPALQSAEIMAEMDLEKFGAEFGAAAAAASSLPELRRAVGRMALEARTVTEAERLAVIESRLPSHSWPERALKVVAVDAGSGEARVFDRDSGVPLVDAVAASCAVPGVWPPVTVDGHRYVDGGVRSMANADYADGADRLVVLLPLGATDPFPTERPVERVVAERRAAGAEVWVIEPDEASRAAIGDNALDPATRRPAAEAGRAQGRELTPPWDDRG
>NC_021985.1|WP_148305756.1|6727027_6727297_+|hypothetical-protein
MPSPCTNSVTAFGGTGSVAKAALDAAGAAISASASRFVHHPYHDGAVPAASRQSTYAARTDGGLPATVARTGPTGAAPRLDPLRTVRHQ
>NC_021985.1|WP_020943028.1|6725906_6726965_+|C40-family-peptidase
MPKRKGRPVLHAVTVLSLLAGSAYFTYELRKDEEAKVPAVQAVTDRPDLENSGKATGKQTWERLHNPTRSVLRGENGDILGTFTDGARTATLRGPSRTFTEPANTQSRVVTQDWVRLMPEAWHKGAEKEKWFKDWFKEYNGSEADDIFAIAFQYVQGAPVKKDDEGVPYAGDAVFGPFKADGVDRLEQNDFYDYLGINYTFRNGTTMVARKERYRALDCSGFMRMVWGYRARFPLMATNTDGDGLPRSADGMARSKVGVDVLKLSGPSPWYTRPQNIDVVQPGDLLFFKMDHRTGNHLDHVAMYLGVDTDGHRVFISSRKEVNGPTMGDKGGASRIDGNGFYAGLLRSAKRL
>NC_021985.1|WP_020943027.1|6725386_6725869_+|poly-gamma-glutamate-biosynthesis-protein-PgsC/CapC
MIPSVLTPEIAAIGIGLGLMFSLICYLTTNLSPGGMITPGWLALTLIEDLQRAALVVGVTVLTYASTLLLQRFVILYGKRLFAAVVLTGVLIQATVIIVLQMEFPLLYANQTLGFIVPGLVGYQLVRQPKGATLLSTGSVTLATYVVLTAGILLGAMPSA
>NC_021985.1|WP_020943026.1|6723737_6725390_+|poly-gamma-glutamate-synthase-PgsB
MLFLYAVLMVGCAILLVAGVVEQRRHFTNLNHVPARVLVNGIRGKSSITRLCAGALRGGGLVTVAKTTGTAARFIHPDATEEPVYRKFGIANVVEQIGIVRRAAAYHPDALVIECMAVMPALQEINQSKLIRSTIGVLCNVREDHLAEMGPTLDDVARSLSRSMPEGGICVTAEQERFAILQEEADSRDCELIYADPETVTDEELRGFSWFTFKENVAIALKVAELLGVERQTALQGMYDAPPDPGVLSVERYVTEDGRKLRFANVFAANDPESTLMNINQLLDLGAIHRPLNVVVNCRPDRVERNGQMGEIIPDLDPEKVFVIGHPAKSAIDAMPAEYRSRAVDLGGERREPEEFMRLLLGELGPDSSLVAIGNIHGQGEHLLEHLAELPADDSEDTPEDGGANAAPSTTPTHGPATAASGRRPVPSGVPEHVETVRLYAPRIDPYQRYSQAYETRYAPQPHVPVQRTAHDPSPRRPDHGEPSEQAYHAYQPHQAAEPWPSVSQGPGGAPARPYGSTEQHGAHGLFEPRLPPAHPADDPQQWRSPGEPR
>NC_021985.1|WP_020943025.1|6721469_6723731_+|cache-domain-containing-protein
MSLLGGIRPPIAVLSALLLSLAAVTALVLGPAGDTRLPEAVRTSQQHFAEDGAIALRASIDESVTDLERSAGLFSAGAPVSGDAVLDKLGNTYQKWMGTAVIEIRSGKLVAARGETVPLTSLDRSELGAEGGLAPRMVRLENGEVRLLSFALLSWPGRPQLLLVASNSLKFPGISLGQFRAIAVVDRAGTILSSDGIPEPEQVLTDLQRKEVTASNKQLRAFAKKAAGQAGRKPLTTKEPGSGGYLGISGSLLGGTWLSDRSVAGYATLSSPQPGEATTATALGLTVVAMVKVAEDPTHTTSPVFGLVAAGALLLIGGIAVAVLLGTVQRPLIRLFLESRRLTRGDLARPVNVPGYGEAHRIGTALERLRRRLLGEPGGDDGPVPAPRGARRIGTRGLLAVSALLLLAWSAPLLLILNRADATVVVPQQLVNDQRERTDTLTDRVRRALNEGEADLQSVASLIGDRTTPADMTKVLDRTLNQHLRYQSLYVVDAAGRVVTRVGGAPHAARTKPATADPIELLGRGGTKPLIVGTAEIPGRDGSALVGEFRIDFLNSMLKRPGLGVVRVVDDHGKVVAGNTGYLAFQSLPSDRLKDLVLAAGQRVGKSAHPAGVLYRENGVQIAGAAPFVGGGPAKELGWTVVSWQPANRLAIPEYDVQHRTVLAGLLGAAAAATCLGWMHIVVARPLRALAEQAEALADGDRKTVLFPRNHDEVGAVTRSLELIRQQLQAQRGPQPAGRRGVPDTASQQQVRN
>NC_021985.1|WP_052352198.1|6719872_6721057_+|CapA-family-protein
MLTPLALVAALAGCGLVGGGDDSAPAGGGRSFTVAAAGDILIHSQLIDQARADAGKTGKGTDGLDFGPLMAGIKPVISKADLAICHMEPVIGKPKGPFESYPDFLIPPQIAGTIKDIGYDTCSTASNHSIDHGYAGVERTLDTLDAAGLKHTGSFRTEKDALTPLIMKVKGVKVAQISFAFGFNAHELPNDKPWLVNQNDLGRIRAAEKRARAAGAEVVILSIHWGREHHPNPSTPQLEFARQLARRTGIDLIIGHHAHVVQPMEKVDGTWIAYGLGNQVARHDVPTGLTEEGVIGWFTFTERDGRWQVEPRYEPTLVEIPPDPEVTADGTPAEPVKGQVRDYRLVDVAAELKRDDLSDVERSRLRLAFERTEGTMLNRGAAKDGLRPLTELPG
>NC_021985.1|WP_043479331.1|6718838_6719660_-|hypothetical-protein
MARSVAAYTGRFTPGGGFRPPGRTERETVAQGVALLLDHHREQAEHRLAEVDFAVRTTVDTVTGRRFAEVYDRVDQGPSPRGWGRVFLDLDHPVRWSVQVPHPVADRDTEQLGVRVLRGAPGGLLVIAGAHRESGEGNAADVAHRRDTVFHAICAELVARRVPGIQLHGFARESAPRYDVIASTGAGADGRAAARRLADELGARHFSVCRAWVRSCPLPGRDNVQGHEAAAHGVAFLHVEFAPGPRTEPATASRAARAVSVVTRGWAGGTRTG
>NC_021985.1|WP_020943033.1|6733220_6734087_+|LysR-family-transcriptional-regulator
MELRQLTYFVAVAEELHFGRAAGRLHIVQSAVSQQIQRLERELGAELFDRSPRRVRLTAAGERLLPEARAVLTAAERARAAVAPPAGLRIGTSTGLGAHLDRVLAAFAAREPDVPVELFSLPAGERLAGVAAGRLDAAFVRAAEPPPGVRVLPLWPDPLVAALPATHPLAARPEVALADLAGLPLALTPRRTNPALVDLLLGACRAAGFEPRPGPVGGSLQDTLATIGSRPLWTVVFASHARVLHTPRVAYLPFRAPGLALPTGLAVPAADPTPHLEKLLLACGDHEG
>NC_021985.1|WP_020943034.1|6734187_6734370_+|4-oxalocrotonate-tautomerase-family-protein
MPIVTVQQGPRDTELKRDLVKRVTDAFVDAYGVPAESVQVWIHEVPADSWGAAGKLTADR
>NC_021985.1|WP_043476645.1|6734469_6735258_-|serine-protease
MFGLRRARPTAAVLVATAAAATALAASPTATAAPQPIVGGTTTTTAAYPFVMQITDASGSQFCGGTLVAPRKVVTAAHCMVGETTSSVRVVGGRTNLNGTDGTVSKVGKIWVNPAYHDATDGDDVAVLTLATSMPYKPAPYVTPSQTGLYASGTTARILGWGTTSENGSSSNQLRTATVPIVSDSGCKSSYGSDFVQSDMVCAGYTSGGVDTCQGDSGGPLLIGGVLAGITSWGEGCAEAGYPGVYTRLTTFSDLVTAQVGS
>NC_021985.1|WP_020943036.1|6735464_6738311_-|helix-turn-helix-transcriptional-regulator
MTVRRDFQEPARCRPDLLIGREDLFTTARDQLASGGSVLLHGAAGIGKSTVLRALADEYGATAHTVLRCSATESESHLPFLALADLLGLVLDDIAPRLPAAQRTALESALTGRGESSLLRDGLALRLAVLSALRALATRGPVLVVADDLQWLDPASAELLGFAARRLEGTPVQLLCAVRTEGQESQEYARHLRSCPPDTVAVRLGPLNRAQVAQLLDHRGHGGLPRSTVREIHRTSGGNPLFALELGRALAESTARPRPGEPLPVPTSLRALVLSRLDMLSVEARRTLLVASAGARPTLTLLHAAGRDNAEAECAQAAELGLLATEQEAPSAVRFAHPLISAALYAEAPAQERRAAHAALSTAASDPIERARHLALATTGTDPEVAARLAEAAALARDRGAPSVAAQLGLLAARHTPADSVPGPDERRLQAAEDAITAGEVDLARDIAREVLTRATVPADRVRAWIIVIDTAGHTMAEVDAVFPQALADAGDDLRLLALVHYQLAWRGLIVEGDFTEAREEAAHAAELAERGGDRRTELLALAFQAQTETLMGHPEAPRTIKRALKEPQDPRVAWHHNGAGSARFRWLVMGDQLVEARATVTALLREVRRRGSVESEVHFLRGLAETELRAGHCGRALELARESLRLARDSGIGETASAMLTSLAEASGGDVDRALALAREAVEHAEEDGDQMYLSRALGALGYAQLVAGDPAGTVRSLRRVRRLELGLGITDPARGRWHGDLAEALVRIGEPAEAQDVIDASREHALRLGRESVLAVLDRAQALVRAALGDQDGAVAQLTSAQDRLAKLGYGLEEARAAFALAQLRTRHTENGPRRTAAYDEATRQFRRCRALPWLRQVEEALTGQQPEPSPAVPETPDARDALAGLASMERQVAALVMEGATNREIAGRLFVSVKTVEATLTRVYRKLGIRSRVDIVRLAAARRAK
>NC_021985.1|WP_020943037.1|6738485_6739328_-|helix-turn-helix-transcriptional-regulator
MAAEAVAAVEIRGALARLRRGTGLPVAFGGLVESGRPQIRISELSGTATAALSSLAVTSGNGLGGKAVALGRPCAVMDYPSSRHISHEYDVPVAAEGIRSVLAVPVVVRRRVRGVLYGALRSAQPLGDRTLDAAVAAARDVEQALVVRDEVRGLLAAAGPEPAAGSRRGDGAGGWEQVREAHAALRALAPRIADPALRAELLAACGLLTATRPAAGTSLAPRELDVLSWVAAGATNAAVGERLGLRPETVKGYLRSAMRRLGAHTRGEAVTAARRAGLLP
>NC_021985.1|WP_020943038.1|6739545_6741219_+|AMP-binding-protein
MTTATELFRSARDFLLEHREDYARAYEGFRWPRPEHFNWALDWFDVIAAGNDRTALHIVEEDGTETRLSFAELAERSNRVANHLRARGVGAEDRVLVMLGNQAELWETALAAMKLRAVVIPATPLLGPADLRDRVERGRVRHVLVRAEDTAKFADVPGAYTRFSVGGLPEEGWEPYEDAYTASAEFVPDGPTLADDPLMLYFTSGTTARPKLVEQTHTSYPIGHLATMFWVGLKPGDVHLNISSPGWAKHAWSNLFAPWNAEATVFIHNYTRFDAARLMSEMDRAGVTTFCAPPTVWRMLIQADLGQLRGRPREVVAAGEPLNPEVIEQVRRAWGVTIRDGFGQTETAVQVSNSPGQRLKTGSMGRPSPGYRVELLDPVSGAPGATEGEIALDLSERPVGLMAGYHGDPDRTAEAMAGGYYRTGDIAARDEDGYLTYVGRADDVFKASDYKISPFELESVLLEHPAVAEAAVVPAPDELRLAVPKAYVVLAEGWEPGPDTAKVVFEHSREVLAPYKRIRRLEFGALPKTVSGKIRRIELREATAAGSAHEYREEDFR
>NC_021985.1|WP_020943039.1|6741215_6742853_+|AMP-binding-protein
MTAATPHAPSAPLPSYTHGTGGTALLGDTIGADLGRAVAAWPGREALVEVATGRRWTYAEFAADVDRLARALLASGIAKGDRVGIWAVNCAEWVLVQYATARVGAIMVNINPAYRTHEVEFVLNQAGISLLFATLGHKSSDYRAMVEEVRGRCPRLTETVYIGDPGWDAFTARGTEDRRDELKAREASLSCDDPINIQYTSGTTGFPKGATLSHHNILNNGFFVGESVGYTEQDRICIPVPFYHCFGMVMGNLAATSHGACMVIPAPSFEPRATLEAVQRERCTSLYGVPTMFIAELNLPGFDGYDLSSLRTGIMAGSPCPVEVMKRVVAEMHMEEVSICYGMTETSPVSLQTRRDDDLEHRTATVGRVLPHLEVKVVDPATGVTQPRGTAGELCTRGYSVMLGYWNEPEKTAEAVDAGRWMHTGDLAVMRDDGYVEIVGRIKDMIIRGGENIYPREIEEFLYAHPKIRDVQVVGVPHETYGEEVLACVIPRDGAEPLTLEELRAFCEGRLAHYKIPSALRLLDAFPMTVSGKVRKIELREAYGS
>NC_021985.1|WP_020943040.1|6742860_6743760_-|hypothetical-protein
MPESVPVRCPVCRRAHVCTAPSYPCACGAPTAVRLDGAAGPAVLAHRAWDEEWVTVRCAACGRGNQWPHPELGCPCGTVLRLALSDAPPAALPSPGPTAPAPTPSPDPAPEPAHPLAPAPAPPPALARPPAPTPPPAPALPPAPAHPPTPALPPTPAAPPASPPAAAPAPARRGPFRPVTIRTARDAVTATALYLRWLGYRGIRRADQRPPSGVGLAAHGLVAQVDPALRPAAPRDVECLWLTAMTESAGCAYFSLAGYDEDARACADTLGVPLFVLGLTGIPTPVNGPGRALAEAGAA
>NC_021985.1|WP_020943041.1|6743978_6745766_+|glyoxylate-carboligase
MARMTAARAAVEILKREGVTDAFGVPGAAINPFYKALKEGGGIHHTLARHVEGASHMAEGYTRTTPGNIGVCIGTSGPAGTDMITGLYSAIGDSIPILCITGQAPTHVIHKEDFQAVDIASIAKPVTKMAVTVLEAAQVPGVFQQAFHLMRSGRPGPVLIDLPIDVQQTEIEFDPETYEPLPAYRPAATRPQIEKAISFLLAAERPVIVAGGGVIGADACDLLVEFAELTQTPVVPTLMGWGALPDDHELNAGMVGVQTSHRYGNANFLESDCVLGIGNRWANRHTGYKLDVYRGDRKFVHVDIEPTQIGKIFPPDYGVVSDARAALELFIEVARDLKGEGRLPDRSAWVASTQERKATLLRRTHFDEVPMKPQRVYEEMNKAFGPDTRYVTTIGLSQIAGAQMLHVYKPRHWINCGQAGPLGWTIPAAIGVAKADPDAPVVALSGDYDFQFMIEELAVAAQHRIPYVHVLVNNAYLGLIRQAQIGLDINFQVNLEFENINTPEIGVYGVDHVKVAEGLGCKAIRVTEPDQLGAAFEQAKKLAAEYRVPVVVEAILERITNISMSRTMDISDISEFEDLATEPGHAPTSLKPLKV
>NC_021985.1|WP_020943042.1|6745863_6746436_-|TIGR04222-domain-containing-membrane-protein
MGGTTRVPAEPHALALLRGGPRAAVVAAVLDLHLRGTVRAGRPGTMRTSGRTSGAPLPALTKAVHASLYRPAGLRQLLERRPVREALGTLRGDLAGAGLLRSFPPGRTRAGRRALRDLRARHPLPAAPDGLSAGDRVLLVALHGDRALTLLAPRFAREAGLTGRGGTTERELRGSWDRGGGGGGFTCGTV

Crispr_ID: NC_021985_15

• CRISPR_ID: NC_021985_15
• CRISPR_location: 7152850-7153137
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 6 spacers

Consensus repeat of NC_021985_15

Consensus_repeat	Method
GGNACCGGNCAGNCNGGG	CRT

spacers of NC_021985_15

>15.1|7152868|27|NC_021985|CRT
AGCGGCCGGCCCGGGACCGGACAGGGA
>15.2|7152913|27|NC_021985|CRT
CCGGGACAGGTCGACAGCGGTCGGCCA
>15.3|7152958|27|NC_021985|CRT
ATCGGCCAGGCAGGGATCGGTCGGACG
>15.4|7153003|27|NC_021985|CRT
CTTGGCCAGCCCGGCACCGGACAGCCC
>15.5|7153048|27|NC_021985|CRT
ACCGGACAGCCCGGCACCGGACAGCCC
>15.6|7153093|27|NC_021985|CRT
ACCGGACAGTCCGGGACCGGCCAGGCA

CRISPR arrays and Neighbor proteins around NC_021985_15

CRISPR arrays

The CRISPR arrays of NC_021985_15

>merge|NC_021985|15|7152850-7153137|CRT
GGGACCGGCCAGGCAGGGAGCGGCCGGCCCGGGACCGGACAGGGAGGCACCGGCCAGGCAGGGCCGGGACAGGTCGACAGCGGTCGGCCAGGGCCTGGACAGGCAGGGATCGGCCAGGCAGGGATCGGTCGGACGGGGACCGGCCAGGCAGGGCTTGGCCAGCCCGGCACCGGACAGCCCGGCACCGGACAGCCCGGCACCGGACAGCCCGGCACCGGACAGCCCGGCACCGGACAGCCCGGCACCGGACAGTCCGGGACCGGCCAGGCAGGGCCTGGCCAGCCCGGG

>NC_021985|15|2|7152850-7153137|CRT
GGGACCGGCCAGGCAGGG	AGCGGCCGGCCCGGGACCGGACAGGGA
GGCACCGGCCAGGCAGGG	CCGGGACAGGTCGACAGCGGTCGGCCA
GGGCCTGGACAGGCAGGG	ATCGGCCAGGCAGGGATCGGTCGGACG
GGGACCGGCCAGGCAGGG	CTTGGCCAGCCCGGCACCGGACAGCCC
GGCACCGGACAGCCCGGC	ACCGGACAGCCCGGCACCGGACAGCCC
GGCACCGGACAGCCCGGC	ACCGGACAGTCCGGGACCGGCCAGGCA
GGGCCTGGCCAGCCCGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020943401.1|7153871_7154315_+|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl|CDD|367422
NC_021985.1|WP_020943390.1|7140967_7141579_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|380339
NC_021985.1|WP_020943395.1|7146408_7147194_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238870
NC_021985.1|WP_020943402.1|7154317_7154689_+|DUF742-domain-containing-protein	unknown	unknown	gnl|CDD|283084
NC_021985.1|WP_020943394.1|7145241_7146174_+|M23-family-metallopeptidase	unknown	unknown	gnl|CDD|366703
NC_021985.1|WP_020943405.1|7156087_7157116_+|L-threonine-3-dehydrogenase	unknown	unknown	gnl|CDD|180054
NC_021985.1|WP_020943403.1|7154666_7155266_+|ATP/GTP-binding-protein	unknown	unknown	gnl|CDD|225138
NC_021985.1|WP_106960635.1|7159938_7160469_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_021985.1|WP_020943404.1|7155329_7155905_+|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|376570
NC_021985.1|WP_020943389.1|7139506_7140892_+|aspartate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|99735
NC_021985.1|WP_020943397.1|7148420_7149599_-|glutamate-dehydrogenase	unknown	unknown	gnl|CDD|133445
NC_021985.1|WP_020943406.1|7157190_7158390_+|glycine-C-acetyltransferase	unknown	unknown	gnl|CDD|235893
NC_021985.1|WP_193384556.1|7147689_7148268_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379409
NC_021985.1|WP_020943410.1|7160499_7160859_+|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl|CDD|377256
NC_021985.1|WP_020943398.1|7149790_7151038_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293841
NC_021985.1|WP_020943393.1|7142675_7144772_+|alpha-galactosidase	unknown	unknown	gnl|CDD|307952
NC_021985.1|WP_020943391.1|7141575_7141698_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020943392.1|7141705_7142503_-|tyrosine-protein-phosphatase	unknown	unknown	gnl|CDD|379135
NC_021985.1|WP_020943407.1|7158420_7159323_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176115
NC_021985.1|WP_020943408.1|7159369_7159942_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|380339

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020943401.1|7153871_7154315_+|roadblock/LC7-domain-containing-protein	gnl|CDD|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	2.60037e-22
NC_021985.1|WP_020943390.1|7140967_7141579_+|helix-turn-helix-domain-containing-protein	gnl|CDD|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.54502e-23
NC_021985.1|WP_020943395.1|7146408_7147194_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238870	cd01832, SGNH_hydrolase_like_1, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.	2.35039e-71
NC_021985.1|WP_020943402.1|7154317_7154689_+|DUF742-domain-containing-protein	gnl|CDD|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	8.20126e-35
NC_021985.1|WP_020943394.1|7145241_7146174_+|M23-family-metallopeptidase	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.00564e-38
NC_021985.1|WP_020943405.1|7156087_7157116_+|L-threonine-3-dehydrogenase	gnl|CDD|180054	PRK05396, tdh, L-threonine 3-dehydrogenase; Validated.	0
NC_021985.1|WP_020943403.1|7154666_7155266_+|ATP/GTP-binding-protein	gnl|CDD|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	2.70057e-45
NC_021985.1|WP_106960635.1|7159938_7160469_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.28025e-11
NC_021985.1|WP_020943404.1|7155329_7155905_+|GAF-domain-containing-protein	gnl|CDD|376570	pfam01590, GAF, GAF domain. This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.	1.61818e-13
NC_021985.1|WP_020943389.1|7139506_7140892_+|aspartate-aminotransferase-family-protein	gnl|CDD|99735	cd00610, OAT_like, Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, alanine-glyoxylate aminotransferase, dialkylglycine decarboxylase, 4-aminobutyrate aminotransferase, beta-alanine-pyruvate aminotransferase, adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and glutamate-1-semialdehyde 2,1-aminomutase. All the enzymes belonging to this family act on basic amino acids and their derivatives are involved in transamination or decarboxylation.	2.66299e-137
NC_021985.1|WP_020943397.1|7148420_7149599_-|glutamate-dehydrogenase	gnl|CDD|133445	cd01076, NAD_bind_1_Glu_DH, NAD(P) binding domain of glutamate dehydrogenase, subgroup 1. Amino acid dehydrogenase (DH) is a widely distributed family of enzymes that catalyzes the oxidative deamination of an amino acid to its keto acid and ammonia with concomitant reduction of NADP+. Glutamate DH is a multidomain enzyme that catalyzes the reaction from glutamate to 2-oxyoglutarate and ammonia in the presence of NAD or NADP. It is present in all organisms. Enzymes involved in ammonia assimilation are typically NADP+-dependent, while those involved in glutamate catabolism are generally NAD+-dependent. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha -beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.	3.60015e-68
NC_021985.1|WP_020943406.1|7157190_7158390_+|glycine-C-acetyltransferase	gnl|CDD|235893	PRK06939, PRK06939, 2-amino-3-ketobutyrate coenzyme A ligase; Provisional.	0
NC_021985.1|WP_193384556.1|7147689_7148268_-|TetR-family-transcriptional-regulator	gnl|CDD|379409	pfam13977, TetR_C_6, BetI-type transcriptional repressor, C-terminal. This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C-terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	3.13686e-17
NC_021985.1|WP_020943410.1|7160499_7160859_+|MmcQ/YjbR-family-DNA-binding-protein	gnl|CDD|377256	pfam04237, YjbR, YjbR. YjbR has a CyaY-like fold.	2.38013e-17
NC_021985.1|WP_020943398.1|7149790_7151038_+|MBL-fold-metallo-hydrolase	gnl|CDD|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.11352e-72
NC_021985.1|WP_020943393.1|7142675_7144772_+|alpha-galactosidase	gnl|CDD|307952	pfam02065, Melibiase, Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.	9.14215e-147
NC_021985.1|WP_020943392.1|7141705_7142503_-|tyrosine-protein-phosphatase	gnl|CDD|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	1.24198e-79
NC_021985.1|WP_020943407.1|7158420_7159323_+|LysR-family-transcriptional-regulator	gnl|CDD|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.58661e-56
NC_021985.1|WP_020943408.1|7159369_7159942_+|helix-turn-helix-domain-containing-protein	gnl|CDD|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.61589e-13

Protein sequences

>NC_021985.1|WP_020943398.1|7149790_7151038_+|MBL-fold-metallo-hydrolase
MTGLRSQSFGLSVLRPAAFGADPGGERLARIRRSPHFKDGVFQNPGGVARTRPSGSTVELAKVFLDKDTRPLRTPRGTVPVHPTTFADLAAPPATGLRVTWMGHSSVLVEIDGRRVLFDPVWGERCSPFPFAGPKRLHPVPLPLAALGPVDVVVISHDHYDHLDMPSIKALAGTDTVFAVPLGVGAHLEHWGVSPDRLRELDWHESTRIGGLTLTATPARHFCGRGLRNTQHTLWASWVVAGEEHRVYHSGDTGYFDGFAEIGAAHGPFDTTMIQIGAYSEFWPDIHMTPEEGLRAHLDLQGGAPHGVLLPIHWGTFNLAPHAWAEPGEWSKEAAEEAGQAVALPRPGEPFEPAGKVPAQAWWRSASAPVPHLWRRPAATPVPPVGARVAVDAADAADAVDVDAVSADADLAGER
>NC_021985.1|WP_020943397.1|7148420_7149599_-|glutamate-dehydrogenase
MAAPLMSLVWTDHVTGRQGFLVVDRLVRGVASGGLRMRPGCTLEEVTGLARGMTMKEALHYDPDARYVPLGGAKGGIDCDPRDPGAYGLLVRYLRAMRPYIESCWTTGEDLGLTQDLVDRAAAEAGLVSSVQAVYPLLDDEAAARGRLADAFAVEVDGIGLDELAGGCGVAESVLTALDRASVPYRGTRVSVQGLGTMGGATARFLSRAGLTVVAVADVRGTMANPEGLDVEALLAARDAYGTVDRAALRPGDRELPGDAWLSADAEVLVPAAVSYAVGAAEQGRVTARWIAEAANMPVRPEAEAALAARGVTVLPDVVVNSATNAWWWWTLFGDIGADADEAFDRVRRSVRALTGQVLARAETGRTTARAAAHALAEDRLAALADRFGCYR
>NC_021985.1|WP_193384556.1|7147689_7148268_-|TetR-family-transcriptional-regulator
MLRAAVGQIEERGVAAVRIADVASALGVSNALVLYHFSTKEKLVAAAFAYAAEGDLARLRALLGRRTSALRRLRAAVRWYAPTGQAKGWRLWIEGWAVALREPALREVTRDLDRRWKAAIAAVLAEGVAAGEFACADPEAAALRLTALLDGLAVQLTSYPGAVPRSRAQRWVDDALARELGLPREALTARGR
>NC_021985.1|WP_020943395.1|7146408_7147194_+|SGNH/GDSL-hydrolase-family-protein
MIGSYVALGDSFTEGVGDPGPDGAFVGWADRFAVLLADRRPEGDFAYTNLAVRGKLLDQIVADQLPKAVELAPDLVSFCAGGNDIIRPGTDPDEVAERFERALARLAAAAGTVMVTTGFDTRGVPLLKHLRGKIATYNGHVRAIADRYGCPVLDLWSLKSVQDRRAWDGDRLHLSPEGHTRVALRAGQALGLEIPADPEQAWPPLPPRGTLEVRRDDVHWAREYLVPWIGRRLRGESSGDHVTAKGALSPDDIKMRIASVA
>NC_021985.1|WP_020943394.1|7145241_7146174_+|M23-family-metallopeptidase
MPAKGKHRRPRNRRLSRAVAAAGTGGAALALPLVGAAAAHAGTPQTAPGQPARSLPAVQNAAVKKAAAQSGQGVRSYTVKTGDCLARIADEQQVRGGWQRLYQDNRQAVGADPALIHPGLRLALGVKAQPVHTGSSAASRTAQRPQPAPSAPAAQPAPAAPAVQSAPAAQAAPATGYTLPVTGGTIGTGYHVPGSMWSSGHHTGVDFVVPTGTPVKAVAAGTVVSAGWGGAYGNQVVLRLGDGHYAQYGHLSRLSVSAGQSVTAGQQVGLSGATGNVTGPHLHFEIRTTPDYGSDVDPVGYLRSHGVPVG
>NC_021985.1|WP_020943393.1|7142675_7144772_+|alpha-galactosidase
MVDIGENGRTWLLSGPTSSYALHLTEADELLHLHWGPRIALADAEALAERPLPDYRPFESPLDGREEYPVEGGPRFVRPALSVRTGERRGTEWRFVSCETGDGTGTGGGADELRLCFDDDGVAITLHHRMRGDVVERWVTVANGGDARVELLRADAATWTLPEREGWRLSQLHGRWAAESLLTTAPLTFGEKVIGSRRGHTGHQHLPWVALDTDATEERGEVYGCALGWSGSWRIAVAQLPDARVQITGGAGWDDSGLLLLEPGESYTTPVFAGLWSDGGFGGASRTWHAYQRDHVIPDAERDRPVLFNSWEATGFGISEDQQTALARHAADIGVELFVVDDGWFGARTGDRAGLGDWTPNPDRFPQGLKPLADRVHGLGMQFGIWVEPEMVNADSDLYRAHPDWVQYQAGRRRTELRNQLVLNLAREDVREYLWGQMDDLLSSAPIDYVKWDFNRCFTDAGWPGEPYPQRLWIDHVRAFYALLDRLRAAHPRVAFESCSGGGGRIDLGVLSRTDQVWTSDNTDPLDRLAIQHGFSQIHPARVMAAWVTDSPNTQLNGRVSSLRFRFVSAMAGVLGVGGDLTAWTGEELAEARRWVELYKEIRPVVQRGEQYRLRPPAGGQSAVQYVLGDESVVLACLQAQRFGEPVPALRLRGLDPLASYECRETGEVHRGAVLLHHGLRTGLRGDLDATVLRLRRV
>NC_021985.1|WP_020943392.1|7141705_7142503_-|tyrosine-protein-phosphatase
MTQQVPSTEPELAAVRNFRDVGGLPTVDGRRVRHGVLFRSGHLAHATAEDAAFLGSLGLHTIFDFRNAADQKLEGPDVELPGVRNVNLPLSDPADGAEFWKMVRAGDLDQLRSILADGKGAARMVASYRAIVTQRTAEHSRVLQALAEDSVPALMHCAAGKDRAGISIAVTLLAVGVEREAVVADYLESNAKHRRYKVRRAGNPDTAYTPEVMELLSPLFDARAEYLSAAFAAIEETWGDLDTYFEQGLRLTPAARERLRERLVD
>NC_021985.1|WP_020943391.1|7141575_7141698_+|hypothetical-protein
MSDFEEKFPRSLWVRLIIYIAVGHLFAAFLYLLFALGAKS
>NC_021985.1|WP_020943390.1|7140967_7141579_+|helix-turn-helix-domain-containing-protein
MNAPEPGPGDGLPAVAPQLRALRRRAGLTLEAAARSAGLSPAHLSRLETGQRQPSLPMLLALARIYGTTVSDLLGETVAERDSIVRAPDMEPTHAGGWTYFQAGSSGRGMQALRVRVPYGTQGDIVRVHPGEEWLYVLKGRLRLRLGDTAHLLAPGDSAHFDSLTPHRLAAEDHDGVELLFVHTLLQSPTATLCLGHPTGELP
>NC_021985.1|WP_020943389.1|7139506_7140892_+|aspartate-aminotransferase-family-protein
MTTEFDLGALLAERGAERYELHTKYLNPQLPRMLHTIGFDKVYERGEGAHFFDADGNDYLDMLAGFGVMGLGRHHPVVRKALHDVLDAGLADLTRFDCQPLPGLLAERLLAHSPHLDRVFFGNSGTEAVETALKFARYATGRPRILYCDHAFHGLTTGSLSVNGEDGFRDGFAPLLPDTAVPLGDLDALARELKKGDVAGLIVEPIQGKGVHEAPPGYLRAAQELLRRHKALLIADEVQTGLGRTGDFYAYQHEDGVEPDLVCVAKALSGGYVPVGATLGRDWIFRKVYSSMDRVLVHSASFGSNAQAMAAGLAVLSVMENEQIVAGVRRTGDLLKARLTALVDRYELLADVRGRGLMIGIEFGRPSSLKLRGRWTMLQAARKGLFAQMVVVPLLQRHRILTQVSGDHLEVIKLIPPLVVDEADVDRFVTAFTAVMDDAHSGGGLMWDFGKTLIKQAVANR
>NC_021985.1|WP_020943401.1|7153871_7154315_+|roadblock/LC7-domain-containing-protein
MASDAPTAQASDLDWLLSGLVQRVPHTASAVLLSCDGLVKSVHGLDADSADHMAALASGLYSLGRSAGIRFGDGGDVRQVVVELDSTLLFVTTAGSGTCLAVLAGREADAAVLGYEMAMLVKSVRPYLVTAPRRHADETAAITATRP
>NC_021985.1|WP_020943402.1|7154317_7154689_+|DUF742-domain-containing-protein
MAAAGDGPWLDDAAGRLVRPFTVSNGRTEPTIALDLMSQVMATGVTPLGYLGPEHAQALDLCRAPVPVAEVAAHLRLPAVVTKVLLSDLVDCGALTTKPPAFHHNPTDRSLLEAVLDGLRRQL
>NC_021985.1|WP_020943403.1|7154666_7155266_+|ATP/GTP-binding-protein
MDYDDSCDPFPTALKILVAGGFGVGKTTFVGAVSEIAPLSTEELLTTVSAGTDNLDGIENKVETTVAMDFGRITLDPEHVLYLFGTPGQERFWFMWDELSEGALGAVVLADTRRLDECFAAVDFFEERGLAFVIAVNEFDGSYRYDPEEVRAALDLDSGIPVVRCDARISSSGVQTLLTLVRHLIAHAPAPAPSHGAHM
>NC_021985.1|WP_020943404.1|7155329_7155905_+|GAF-domain-containing-protein
MSYEPPRPVRGLLLTPEDKEAPARVSRLRRLGLGSRPEPGLDAFADHLAQLTGAPYAMVNFIGADHQFFAGLRTPLTAPVLRADGTRPEVGRVMPRDHGFCPHVVVRRKALVLEDVRDYPRFAGNPVVDDYGIRSYLGAPVFDGSGMALGTVCAFDVAPRAWGRSGLETIKALAAEVAVRIQRSADDGLPI
>NC_021985.1|WP_020943405.1|7156087_7157116_+|L-threonine-3-dehydrogenase
MKALVKEKAEPGLWLTDVPEPAIGPGDVLIKVMRTGICGTDLHIRAWDGWAQQAISTPLVLGHEFVGQVVETGRDVTEIRVGDRVSGEGHLVCGKCRNCLAGRRHLCRATVGLGVGRDGAFAEYVALPASNVWVHRVAVDLDVAAIFDPFGNAVHTALSFPLVGEDVLITGAGPIGLMAAAVARHAGARNVVVTDVSEERLELARKIGATLALNVSRSSIADGQRELGLREGFDIGLEMSGRPEAMRDMIANMTHGGRIAMLGLPAEEFPVDWARIVTSMITIKGIYGREMFETWYAMSVLLEGGLDLAPVITGRYGYRDFEAAFADAASGTGGKVILDWTA
>NC_021985.1|WP_020943406.1|7157190_7158390_+|glycine-C-acetyltransferase
MFDSVRDDLRATLDEIRAAGLHKPERVIGSPQSATVAVTAGGRPGEVLNFCANNYLGLADHPAVITAAHQALDRWGYGMASVRFICGTQEVHKELEARLSAFLGQEDTILYSSCFDANGGVFETLLGEEDAVISDALNHASIIDGIRLSKARRFRYANRDLADLEAKLKEATAGGARRKLVVTDGVFSMDGYVAPLSEICDLADRYDAMVMVDDSHAVGFVGPSGRGTPELHGVMDRVDIITGTLGKALGGASGGYVAARAEIVALLRQRSRPYLFSNTLAPVIAAASLQVLDLLESADDLRVRLAENTALFRRRMTEEGFEILPGDHPIAPVMIGDAARAARLAELLLERGVYVIGFSYPVVPQGQARIRVQLSAAHSTEDVDRAVDAFVAARAELEA
>NC_021985.1|WP_020943407.1|7158420_7159323_+|LysR-family-transcriptional-regulator
MIEARRLHILRAVADHRTVTAAAAALYLTPSAVSQQLTALEQETGHRLVERGARGVRLTQAGEILLSHTNAVLAQLERAEAELAAYGSGEAGTVTVAAFATGIAQVVAPAVARLASTAPGIRIRVQDAEGDASLPMVLDRQVEVAVAVEYRGAPAADDPRLTHVPLYAEPFDAVVPVGHRLADAFEIPLADLGKDLWISPYPGNPCHDVVVLACENAGFQPRFAHSSDDFRAVVALAAADAGVALVPRSALRGMDLAGVVVRPVDGVAPTRRVFAAVRRGAEGHPLIRPVLQALGEAAQA
>NC_021985.1|WP_020943408.1|7159369_7159942_+|helix-turn-helix-domain-containing-protein
MRNEGPDPVDARLGARLAELRAGRGWSLGELAERSGVSRSTLSRAERAETSATAAVLNRLCHVYGRTMSQLLSEVEAEPAPLVRAADQRVWQDPGAGFTRRSVSPPHPGLRGELVEGRLAPGADLAYDRPPVPGIEQHLWVLDGALEVTVDGTGHPLGAGDCLRMRVFGPTRFRCTGPAAARYALAVVRP
>NC_021985.1|WP_106960635.1|7159938_7160469_+|GNAT-family-N-acetyltransferase
MRVRRWDEERIRRGGDGLALLLADTVAGGASVGFLAPLTPAAADAWWRERADAVAAGRLQVWVAEDGAGRPAGTVGLAMPDKPNSRHRAELVKLMVHRRARGAGLGRLLLATAEQAAAAAGLTLLHLDTETGSPAERLYRSAGWTRAGTIPDYAANPAGELCPTTLYYKRLAPAAR
>NC_021985.1|WP_020943410.1|7160499_7160859_+|MmcQ/YjbR-family-DNA-binding-protein
MPDAEDVRRIALSLPDTTEKTAWNMPTFRVAGKMFATLPEDETSLAVRCPKEERDELVLAEPGKFWIAGHEAQFAWVRARLAALEDEDELRDILADSWRQAAPSRLLDDHPELGLPGGR

Crispr_ID: NC_021985_17

• CRISPR_ID: NC_021985_17
• CRISPR_location: 7447627-7447703
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of NC_021985_17

Consensus_repeat	Method
GACGGCACCGGCGACGGGGTGGC	CRISPRCasFinder

spacers of NC_021985_17

>17.1|7447650|31|NC_021985|CRISPRCasFinder
CCGCGGTCAGCCCAGGCGCTTCAGCAGCTCC

CRISPR arrays and Neighbor proteins around NC_021985_17

CRISPR arrays

The CRISPR arrays of NC_021985_17

>merge|NC_021985|17|7447627-7447703|CRISPRCasFinder
GCCGTCACCCGCCCCCGGGTGCCCCGCGGTCAGCCCAGGCGCTTCAGCAGCTCCTCCGCCACCTGCGCCGAGGAGGC

>NC_021985|17|14|7447627-7447703|CRISPRCasFinder
GCCGTCACCCGCCCCCGGGTGCC	CCGCGGTCAGCCCAGGCGCTTCAGCAGCTCC
TCCGCCACCTGCGCCGAGGAGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020943658.1|7457746_7458418_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224095
NC_021985.1|WP_020943644.1|7444424_7445390_-|pirin-family-protein	unknown	unknown	gnl|CDD|224655
NC_021985.1|WP_020943641.1|7440638_7442651_+|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319849
NC_021985.1|WP_043476879.1|7446966_7447500_-|hypothetical-protein	unknown	unknown	gnl|CDD|237865
NC_021985.1|WP_043476872.1|7443100_7444138_-|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NC_021985.1|WP_020943651.1|7450208_7452089_-|glycoside-hydrolase-family-47-protein	unknown	unknown	gnl|CDD|366693
NC_021985.1|WP_020943642.1|7442647_7443058_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043479540.1|7440128_7440530_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
NC_021985.1|WP_020943653.1|7452943_7453924_-|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|179673
NC_021985.1|WP_020943638.1|7436923_7438297_-|ATP-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|223516
NC_021985.1|WP_020943639.1|7438536_7439823_+|PAS-domain-containing-protein	unknown	unknown	gnl|CDD|197715
NC_021985.1|WP_020943652.1|7452569_7452926_+|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380395
NC_021985.1|WP_043479543.1|7448480_7449398_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NC_021985.1|WP_020943656.1|7456430_7457003_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_021985.1|WP_020943645.1|7445837_7446176_-|hypothetical-protein	unknown	unknown	gnl|CDD|378275
NC_021985.1|WP_043476875.1|7446172_7446904_-|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|132028
NC_021985.1|WP_020943650.1|7449440_7450025_-|HD-domain-containing-protein	unknown	unknown	gnl|CDD|129396
NC_021985.1|WP_020943654.1|7454060_7455422_-|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|226082
NC_021985.1|WP_020943657.1|7457069_7457750_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224095
NC_021985.1|WP_020943655.1|7455418_7456276_-|MoxR-family-ATPase	unknown	unknown	gnl|CDD|223786

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_021985.1|WP_043479540.1|7440128_7440530_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	4.4e-16	54.1	0.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020943644.1|7444424_7445390_-|pirin-family-protein	gnl|CDD|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	1.91802e-61
NC_021985.1|WP_020943641.1|7440638_7442651_+|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319849	cd07551, P-type_ATPase_HM_ZosA_PfeT-like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron. Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_021985.1|WP_043476879.1|7446966_7447500_-|hypothetical-protein	gnl|CDD|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	1.49638e-07
NC_021985.1|WP_043476872.1|7443100_7444138_-|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	8.62869e-34
NC_021985.1|WP_020943652.1|7452569_7452926_+|cupin-domain-containing-protein	gnl|CDD|380395	cd06990, cupin_DUF861, domain of unknown function DUF 861, cupin domain. This family contains proteins which seem to be specific to bacteria and some fungi. The function of this family is unknown but contains a cupin domain without a metal binding site. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin (cupa is the Latin term for small barrel).	1.2704e-57
NC_021985.1|WP_020943651.1|7450208_7452089_-|glycoside-hydrolase-family-47-protein	gnl|CDD|366693	pfam01532, Glyco_hydro_47, Glycosyl hydrolase family 47. Members of this family are alpha-mannosidases that catalyze the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).	3.12931e-112
NC_021985.1|WP_020943650.1|7449440_7450025_-|HD-domain-containing-protein	gnl|CDD|129396	TIGR00295, Uncharacterized_protein_MJ0778, TIGR00295 family protein. This set of orthologs is narrowly defined, comprising proteins found in three Archaea but not in Pyrococcus horikoshii. The closest homologs are other archaeal proteins that appear to be represent distinct orthologous clusters. [Hypothetical proteins, Conserved].	0.000105021
NC_021985.1|WP_020943653.1|7452943_7453924_-|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|179673	PRK03910, PRK03910, D-cysteine desulfhydrase; Validated.	2.59698e-121
NC_021985.1|WP_043479540.1|7440128_7440530_-|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.32204e-16
NC_021985.1|WP_020943638.1|7436923_7438297_-|ATP-grasp-domain-containing-protein	gnl|CDD|223516	COG0439, AccC, Biotin carboxylase [Lipid metabolism].	2.47492e-24
NC_021985.1|WP_020943639.1|7438536_7439823_+|PAS-domain-containing-protein	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	9.44374e-13
NC_021985.1|WP_020943658.1|7457746_7458418_+|ABC-transporter-permease	gnl|CDD|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	6.7025e-51
NC_021985.1|WP_043479543.1|7448480_7449398_+|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.28328e-32
NC_021985.1|WP_020943656.1|7456430_7457003_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.15015e-09
NC_021985.1|WP_020943645.1|7445837_7446176_-|hypothetical-protein	gnl|CDD|378275	pfam09850, DotU, Type VI secretion system protein DotU. DotU is a family of Gram-negative bacterial proteins that form part of the membrane-joining complex of the type VI secretion system. DotU binds tightly to IcmF and together they are tethered to the inner membrane at one end and the peptidoglycan layer at the other; they interact with Lip1 which then tethers the peptidoglycan layer to the outer membrane.	0.00023444
NC_021985.1|WP_043476875.1|7446172_7446904_-|SigE-family-RNA-polymerase-sigma-factor	gnl|CDD|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	1.0156e-30
NC_021985.1|WP_020943654.1|7454060_7455422_-|VWA-domain-containing-protein	gnl|CDD|226082	COG3552, CoxE, Protein containing von Willebrand factor type A (vWA) domain [General function prediction only].	5.7272e-45
NC_021985.1|WP_020943657.1|7457069_7457750_+|ABC-transporter-permease	gnl|CDD|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	7.04276e-51
NC_021985.1|WP_020943655.1|7455418_7456276_-|MoxR-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.22517e-43

Protein sequences

>NC_021985.1|WP_043476879.1|7446966_7447500_-|hypothetical-protein
MSAHRVPRPRRIRRLRAVLGVSAVGAALAVAGTVTAQAVQGDAHPAPHADRTATPSPVPSPARTATPSPVPSPARTATPSPVPSPVRTATPKPVPSPTRPGGPKPSPAPATPRPVPSTTLPATATPSPVPSVPGRATAAPVPAPAPARPHGHGHLTAAPRPVPAPGHATAAPVPQHH
>NC_021985.1|WP_043476875.1|7446172_7446904_-|SigE-family-RNA-polymerase-sigma-factor
MTTATPPAALPWDRAAAPESGAPSWRRFRRALRPHVPRARVPRRRALCARVLARVGIGTAAGPAPSGRGDGTTAPALRAPSSPSGIEELYHHRRLSLVRLAVLLVDDVPTAEDVVQDAFTALFRRHGHRLGTLDDPEAYLRTSVVNGARSVLRRRRTVRAHTPEPERHAPAPEEDVLLHEDHREVLAALRTLTTRQREVLVLRYWSHLTEAEIAATLGLSRGTVKSTASRAIDALGRRLEGLR
>NC_021985.1|WP_020943645.1|7445837_7446176_-|hypothetical-protein
MSTSGTSTAAVEERLRAALDARARSVGPADLRPLRPPAATGRPRGTVPRRTAMGLLALAAVAALVFLAVRGGPDRPAEPAHRPRPPATGTPTPVPSPVRPTTAQPSPSVPGP
>NC_021985.1|WP_020943644.1|7444424_7445390_-|pirin-family-protein
MSNLDRAPVPSVCGGRGFVVAEPVRELLSPRHVKLGESTEVRRLLPNLGRRMIGAWAFVDHYGPDDIAGEPGMQVPPHPHIGLQTVSWLHEGEVLHRDSTGSLQTIRPKQLGLMTSGRAISHSEESPRSHARFLHGAQLWVALPDEHRHTEPMFEYHADLPTVTAPGLTATVILGGLDGSSSPGTTFTPIVGADLALTRGTDVRLPLERDFEYGVLAMSGEVHVDGVPVLPGSMLYLGCGRTELPLRAESDAGIMLLGGEPFAEELIMWWNFVGRTQQDIEQAREDWTTGSRFGEVKGYDGAPLRAPELPPVPLKARGRVR
>NC_021985.1|WP_043476872.1|7443100_7444138_-|C40-family-peptidase
MASHRRPKQPSRTRVTVLTTAAAAAVALSANAANAAPGEKLGKDEVKAKVDKLYEQAEQATEKYNGAKEKQQKLQKEISTVQDNVARGQQELNKLREGLGSMATAQYRSGGIDASVQLFLSSDPDDFLDKASTLDQLSSQQVEALKKIQDKQRELAQERAEATEKLKDLASTRTELGNKKKEVQGKLAEAQKLLNTLTAKEKAALDAEQQRANRSSTERVELKDAPPASGRAGAAFSAAQSQIGKPYVYGATGPSSFDCSGLTSWAYAQAGVSIPRTSEAQSGIGTRLTRSQLQVGDLVFFFNDLHHVGLYAGNGQVLHAPRTGTVVRYESMDTIGGPFMFGVRV
>NC_021985.1|WP_020943642.1|7442647_7443058_+|hypothetical-protein
MSRRDRGSRRAPAAAPAPCAVTVCRGCCCGTEKVPGVDHAAQLALLRQSLSGAAQVRVTGCLDACEQANVVVVQPSAAGRAAGGRPVWLGLVHDTDAVRDIAAWITAGGPGLADPPGVLDLYAFTPSRRVRQSVED
>NC_021985.1|WP_020943641.1|7440638_7442651_+|heavy-metal-translocating-P-type-ATPase
MSSTLTRPAPPGAARESVAPRRRTRLLALPEARWAAAALVLFLIALPLYLAGAPAWTWGTLFAAVYATGGWEPGRAGLRALREKTLDVDLLMVVAALGAAAIGQVLDGALLIVIFATSGALEAIATARTADSVRGLLDLAPATATRVADDGTEETVPGERLAVGEIILVRPGERIGADGRVLDGAGEVDQATITGEPLPVAKAAGDEVFAGTLNGTGALRVKVERDPSDSVIARIVAMVEEASGTKAPTQLFIEKVEQRYSLGMVAATVALFVLPLLVGADLRSTLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVMERLGQVDAVALDKTGTLTEGTPRVTDVRPLPGPGLPEDEVLRLAAAAEHPSEHPLARAIVDAARDRGLDIPLVRDFGSAPGTGVSATFEGRSVAVGSPARLPDGRTGGPAGEEAAAPEMTRALDVAAALEEEGRTAVLVTVDGRPAGVLGIADRLRDEAAATVAALGELAGTTPVLVTGDNPRAAARLAGEVGIDDVRAGLLPQDKVAAVREWERAGRKVLVVGDGVNDAPALAAAHTGIAMGRAGSDLALETADAVVVRDELATVPAVVRLSRRARRLVVQNLVVAAVFITGLVIWDLAGTLPLPLGVAGHEGSTVIVGLNGLRLLADGAWRRAHAGTDR
>NC_021985.1|WP_043479540.1|7440128_7440530_-|winged-helix-turn-helix-transcriptional-regulator
MGHGAAQPSGRVPRRNLDAASAAKVATTLQALATPSRLLILARLREGSLPATELAAEVGMEQSACSHQLRLLRNLGLVVGTRKGRSIVYSLYDNHVAALIDQAIYHVEHLRLGLTDSAALTEAEEEGAGVPSA
>NC_021985.1|WP_020943639.1|7438536_7439823_+|PAS-domain-containing-protein
MDEADLKTLLAPLPVSWWEADGGARLVESGGGAFADERTARRFLRALCAEAGGAARLPADGPYRARFEGRTFDVNWPAHEGGTATGRSRGVAVEVAGAAAGTGPYASFADLSPAAVFVRDTDGRCVWANHAYAHLYGTTRDALIGRHLAEIDGADDAARFLALDEQVLSGGHSARHTLAFRHTDGSAGHAVGYRFPVHWGTRRCVAGIYVDITDYTRALEQRRRAEADLCALRDHSGLACLRLSADGVVRDAGTAAAEVLHVRLGDLLGSPADTLLARTPERTALHRVWDDLIAGRRRSARTSAVLVDGDRRRRAWIHLSAVQHAAEHLPGVWAVITRLGLSHEAHPPLTPAQVRILALLAAGHSNADVAGALHLSRQTVDYHLSRLRRLLGVATRPALVARAYALGILSPHAWPPRSTTATHPLSPA
>NC_021985.1|WP_020943638.1|7436923_7438297_-|ATP-grasp-domain-containing-protein
MTKVLYVHAKGGPPVGYALPRVAARSTVHLLALSDLPADMAADPARLCASVLARGDADEHDLVELISSRAREVGADAVITFSEYAVVAVAEAARRLGLRGAGPTAALARDKRLMRAAWERRGIPQPRFRAVATEEQLAAAAIELTCPLLLKAAWSAGSTAHQIIEGPADVAGAWKRSRAVMSESALLGYAELHVGGAGEDFVVEEIVTGCAEEWFDGTGWGDYVSVEGAVVGGVFRPVCLSGRMPTVAPFTERAGITPAAVGARAQARIVELARQAVEALGLQDCGTHTEIKLGADGRMWVIETAARFGGAMTVPQIEEVFGLDLVGMFTDQLLGRAAGWPARALTPEDAEGAAGSLVVLAVDGAGAPWRRRHVWDSASVLRSVPAGAASTLSVVRESSLPDGTPVPVYDPAAGANTMAGLCLMSADRPQTVIRDFTALVDALPRILPAYVGEGVRA
>NC_021985.1|WP_043479543.1|7448480_7449398_+|LysR-family-transcriptional-regulator
MLGGVDTPSLDLNLLRTFLAVYRSGSFTGAARLLGLSQPTVTTQMRALERLSGRELFERLPRGVTPTQVADELAARIAAPLDELAAVAGPGPLEGARPEPVHLAGPAEFLCTQVMPALAPLVAEGVRLRVATGLTEPLLEELRAGRHDLVIATARPRGRALHAVPLGDEEFVLVAAPVWAERLAGRLPAEGPAALQSVPLITYAEDLPIARRYWRHVFGRRLSHTAAVTVPDLRGVLAAVAAGAGFSVLPRYLCAEPLRSGALVALLEPEDAPINTGYLVQRPGASENPDVVRVRELLVREGRTW
>NC_021985.1|WP_020943650.1|7449440_7450025_-|HD-domain-containing-protein
MSAATIATGETDPPLRALPERAAAVLAGVDAPPRLVAHLRAVHDVAARLVEWVRLRCPVLELDAEAVLFGAATHDIGKALHPAELSGPGARHEEAGRELLLGHGVEPRLARFAGTHASWTAPGTGAEDLLVSLADKVWKNKRVTELEDLVVALLAGADGRAAWEWFMELDEVLTEIGDGADRRLAYQMSHPLTR
>NC_021985.1|WP_020943651.1|7450208_7452089_-|glycoside-hydrolase-family-47-protein
MATPPAPGHPAGPANTRLTRRALLRSAAGATAALCALGGPGAAPASAAPGPADPALAEDVRQEFLTAWTAYRRLAWGRDELHPVSGTGSEFFIDSVPLGLTVVESLDTLFLMELDGELDAAVSWIGTRLDFDRDANIHVFEAIIRLVGGLLSGHHCTGDPVLLTKARDLADRLLPAFTSSPTGAPYRYVNLRTGAVSGEQVPLAEIGSNITELGCLSRLTGDRRYLDAAKKALRAPYDRRSALDLVGTTLNVETGGWTDPTARVDPPVDSYFEYLWDAYQFLGDTEIRGWYRTLTSAVLRHLGETRDGRLWFRSADMHSGATTGLGQSELAAFYAGLLAQGGDLAAGESYHSSWAAALTRFPVPPETIDRTTLAATSTQYRLRPEYADSALFLWLLTGKELYRERARWLWDAQRAHCKVPDGYTIVADLRTTPVTRGDLTPGYWFSENMKYFYLLWSGTPRFDYTTNYLTTEGNVLRGAHRVPAPSPSGTFRLLNRATGRAMAVRGASTADGAPVVGRAPGAGADQRWIVTTSDGHTRLTSLHSGKVLEVPRSSTIDGTALHQRAHDGTRGQQWTVQPARDGYQRLVNRHSGKALDVDGTADGAAVVQRTTGGAASQQWRLVAGEG
>NC_021985.1|WP_020943652.1|7452569_7452926_+|cupin-domain-containing-protein
MLEVKTVDKPDERRDFPRGHLEALHLTGLDFAVGTFEPGWRWSESVGPIAGTASCMVHHNGYVVQGRMHLRMDDGGEGEVGPGDVFVCPPGHDAWVVGDEQVVLYDFAGTMANEYAKS
>NC_021985.1|WP_020943653.1|7452943_7453924_-|pyridoxal-phosphate-dependent-enzyme
MSHPPVQLATFPTPAEPAPRLAAAIGLGPDDLWIKRDDLTGTGGGGNKIRKLEWTVGAALAEGADTLVTTGAPQSNHARLTAAAAARLGLAAVLVLRGSPGGSGSGNLALDGLLGARLVWAGDVDRAGLDAAAAEVCERLRASGARPALIPFGGSSALGARGYVRCGEELRAQVPGLRTAVVALGSGGTMAGLVVALGSGAVLGVDVGALADPAAAVREFAAPHTDGDVTADGLRVRRDQVGAGYATLTGPAAEALRLAARTEGIVLDPVYTGRALAGLVAAVRDGDVRPGERTVFVHTGGLPGLFGHAEAVAYAEAGAGSPPAGP
>NC_021985.1|WP_020943654.1|7454060_7455422_-|VWA-domain-containing-protein
MTGVDGRITGLVGALRAHGVRIGTGETVDAALAARELGFADRELLREGLAATLLHGAAQRAVFDPVFDLYFPRGVGAPVGAADDQGADRENLRDRLAAALAADDRSLLAALAAEAVDGFGGYGGSSGSDGWSAYQALDRIRPQTLLARVRADVRARDGGAGFADRLLDDEIRRRIEEFRRLVGADARRRIAERRGRDEIARRAVAPTADRVDFLYAGRDQLAELRRTVQPLARKLATRLAARRRRAARGTVDLRRTVRSSLSTGGVPMRPVLRRRRPVRPELVLLCDVSGSVSGFSDFTMLLVQALHDQFSKVRVFAFVNRLDEVTGLLGRGQADPDGLGARIRAEATLTGWHGSSDYGVALGEFAERWDAAVGPRTTVFVLGDARTNMSDPNLPAVRELARRARRVYWLNPEPRAQWGTGDSAAPDYAGLVEMHECRTARQLGALVARLLPV
>NC_021985.1|WP_020943655.1|7455418_7456276_-|MoxR-family-ATPase
MFSSVDDVSARLAVTGYLASPAVATTAFLAARLGKPLLVEGPAGVGKTELAKAVAEVAGARLVRLQCYEGVDESRALYEWNHAKQLLRISAGRDESWDETRTDIFGEEFLLPRPLLTAIRGDEPTVLLIDEIDKADVEMEGLLLEVLSDFQVTVPELGTITATRRPFVVLTSNAGRELSEALRRRCLFLHIDFPEEELERRIVRLKVPDLDEALAASVVRVVGALRAMDLRKAPSVAETVDWARTLLVLGAGALDETVVRDTLGVLLKHQEDVRKAAAKLDLAAL
>NC_021985.1|WP_020943656.1|7456430_7457003_+|TetR/AcrR-family-transcriptional-regulator
MTTTDKASPRDRLLDAAAQLVYREGVSVGVEALCRAAGVSKRSMYQLFGGKDEMLAASLERQIPWYEARLAPADPDSGTPRERILHVFEQVEKASADPGYLGCPYLAVLVELKDPGHPASEVARTVKARLEHGLRTQAELGGARDPGLLARQLMLVFDGASARAGARVEHLDDGLTTTTVTALLDAAGMR
>NC_021985.1|WP_020943657.1|7457069_7457750_+|ABC-transporter-permease
MIPTPHDCLARNEWICGAYLSTRRRILLDAVVQHVQLTAVSVLIGLVLAVPLAVLARRLPPASGPVLAVTTVLYTIPSLAMFSLLLPLYGLSASLVVAGLVLYSLTLLVRNILAGLRAVPEETRQAARGLGYGPVRLLLTVELPLALPAAMAGLRIATVSAVSLVTVGAIVGFGGLGNLIYAGMNSYFKAQVLTASVLCVVIAVAADLLLLGVQRLLTPWTRAARA
>NC_021985.1|WP_020943658.1|7457746_7458418_+|ABC-transporter-permease
MTTLGAARDWLTDPAHWSGDDGIRHRLLQHLLLVSVCLAVSCLIALPVALVLGHLGRGGALAVNISNAGRAVPTFAVLVLLLLTPVGRWGEGPAVVALVLFAVPPLLTNAYVGVREVDRSVVRAARGMGMTGRQTLLRVELPLARPMILTGVRTAAVQLVATATIAALAGGGGLGRIITAGFNLASTPQVVAGALLVAVFALLVEGVFAAAERLAATRPGSGR

Crispr_ID: NC_021985_16

• CRISPR_ID: NC_021985_16
• CRISPR_location: 7447214-7447309
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of NC_021985_16

Consensus_repeat	Method
GACGGCACCGGCGACGGGGTGGC	CRISPRCasFinder

spacers of NC_021985_16

>16.1|7447237|49|NC_021985|CRISPRCasFinder
CGTGCGCACCGGTGACGGCACCGGCGACGGGGTGGCGGTCCGGGCCGGT

CRISPR arrays and Neighbor proteins around NC_021985_16

CRISPR arrays

The CRISPR arrays of NC_021985_16

>merge|NC_021985|16|7447214-7447309|CRISPRCasFinder
GAGGGGACGGGCTTCGGGGTGGCCGTGCGCACCGGTGACGGCACCGGCGACGGGGTGGCGGTCCGGGCCGGTGACGGTACCGGTGACGGGGTGGCG

>NC_021985|16|13|7447214-7447309|CRISPRCasFinder
GAGGGGACGGGCTTCGGGGTGGC	CGTGCGCACCGGTGACGGCACCGGCGACGGGGTGGCGGTCCGGGCCGGT
GACGGTACCGGTGACGGGGTGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020943644.1|7444424_7445390_-|pirin-family-protein	unknown	unknown	gnl|CDD|224655
NC_021985.1|WP_020943641.1|7440638_7442651_+|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319849
NC_021985.1|WP_043476875.1|7446172_7446904_-|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|132028
NC_021985.1|WP_043476872.1|7443100_7444138_-|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NC_021985.1|WP_043476881.1|7447655_7448351_-|type-1-glutamine-amidotransferase-domain-containing-protein	unknown	unknown	gnl|CDD|153235
NC_021985.1|WP_020943642.1|7442647_7443058_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043479540.1|7440128_7440530_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
NC_021985.1|WP_020943652.1|7452569_7452926_+|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380395
NC_021985.1|WP_020943638.1|7436923_7438297_-|ATP-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|223516
NC_021985.1|WP_020943639.1|7438536_7439823_+|PAS-domain-containing-protein	unknown	unknown	gnl|CDD|197715
NC_021985.1|WP_020943651.1|7450208_7452089_-|glycoside-hydrolase-family-47-protein	unknown	unknown	gnl|CDD|366693
NC_021985.1|WP_043479543.1|7448480_7449398_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NC_021985.1|WP_020943656.1|7456430_7457003_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_021985.1|WP_020943645.1|7445837_7446176_-|hypothetical-protein	unknown	unknown	gnl|CDD|378275
NC_021985.1|WP_020943650.1|7449440_7450025_-|HD-domain-containing-protein	unknown	unknown	gnl|CDD|129396
NC_021985.1|WP_020943653.1|7452943_7453924_-|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|179673
NC_021985.1|WP_020943654.1|7454060_7455422_-|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|226082
NC_021985.1|WP_020943657.1|7457069_7457750_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224095
NC_021985.1|WP_020943637.1|7434896_7436927_-|phosphoenolpyruvate-synthase	unknown	unknown	gnl|CDD|376527
NC_021985.1|WP_020943655.1|7455418_7456276_-|MoxR-family-ATPase	unknown	unknown	gnl|CDD|223786

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_021985.1|WP_043479540.1|7440128_7440530_-|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	4.4e-16	54.1	0.3

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020943644.1|7444424_7445390_-|pirin-family-protein	gnl|CDD|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	1.91802e-61
NC_021985.1|WP_020943641.1|7440638_7442651_+|heavy-metal-translocating-P-type-ATPase	gnl|CDD|319849	cd07551, P-type_ATPase_HM_ZosA_PfeT-like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron. Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_021985.1|WP_043476875.1|7446172_7446904_-|SigE-family-RNA-polymerase-sigma-factor	gnl|CDD|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	1.0156e-30
NC_021985.1|WP_043476872.1|7443100_7444138_-|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	8.62869e-34
NC_021985.1|WP_043476881.1|7447655_7448351_-|type-1-glutamine-amidotransferase-domain-containing-protein	gnl|CDD|153235	cd03141, GATase1_Hsp31_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein. Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein (EcHsp31). This group includes EcHsp31 and Saccharomyces cerevisiae Ydr533c protein. EcHsp31 has chaperone activity. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. EcHsp31 coordinates a metal ion using a 2-His-1-carboxylate motif present in various ions that use iron as a cofactor such as Carboxypeptidase A. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1 domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For EcHsp31, this Cys together with a different His and, an Asp (rather than a Glu) residue form a different catalytic triad from the typical GATase1 domain. For Ydr533c a catalytic triad forms from the conserved Cys together with a different His and Glu from that of the typical GATase1domain. Ydr533c protein and EcHsp31 are homodimers.	1.05031e-84
NC_021985.1|WP_020943651.1|7450208_7452089_-|glycoside-hydrolase-family-47-protein	gnl|CDD|366693	pfam01532, Glyco_hydro_47, Glycosyl hydrolase family 47. Members of this family are alpha-mannosidases that catalyze the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).	3.12931e-112
NC_021985.1|WP_043479540.1|7440128_7440530_-|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.32204e-16
NC_021985.1|WP_020943653.1|7452943_7453924_-|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|179673	PRK03910, PRK03910, D-cysteine desulfhydrase; Validated.	2.59698e-121
NC_021985.1|WP_020943638.1|7436923_7438297_-|ATP-grasp-domain-containing-protein	gnl|CDD|223516	COG0439, AccC, Biotin carboxylase [Lipid metabolism].	2.47492e-24
NC_021985.1|WP_020943639.1|7438536_7439823_+|PAS-domain-containing-protein	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	9.44374e-13
NC_021985.1|WP_020943652.1|7452569_7452926_+|cupin-domain-containing-protein	gnl|CDD|380395	cd06990, cupin_DUF861, domain of unknown function DUF 861, cupin domain. This family contains proteins which seem to be specific to bacteria and some fungi. The function of this family is unknown but contains a cupin domain without a metal binding site. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin (cupa is the Latin term for small barrel).	1.2704e-57
NC_021985.1|WP_043479543.1|7448480_7449398_+|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.28328e-32
NC_021985.1|WP_020943656.1|7456430_7457003_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.15015e-09
NC_021985.1|WP_020943645.1|7445837_7446176_-|hypothetical-protein	gnl|CDD|378275	pfam09850, DotU, Type VI secretion system protein DotU. DotU is a family of Gram-negative bacterial proteins that form part of the membrane-joining complex of the type VI secretion system. DotU binds tightly to IcmF and together they are tethered to the inner membrane at one end and the peptidoglycan layer at the other; they interact with Lip1 which then tethers the peptidoglycan layer to the outer membrane.	0.00023444
NC_021985.1|WP_020943650.1|7449440_7450025_-|HD-domain-containing-protein	gnl|CDD|129396	TIGR00295, Uncharacterized_protein_MJ0778, TIGR00295 family protein. This set of orthologs is narrowly defined, comprising proteins found in three Archaea but not in Pyrococcus horikoshii. The closest homologs are other archaeal proteins that appear to be represent distinct orthologous clusters. [Hypothetical proteins, Conserved].	0.000105021
NC_021985.1|WP_020943654.1|7454060_7455422_-|VWA-domain-containing-protein	gnl|CDD|226082	COG3552, CoxE, Protein containing von Willebrand factor type A (vWA) domain [General function prediction only].	5.7272e-45
NC_021985.1|WP_020943657.1|7457069_7457750_+|ABC-transporter-permease	gnl|CDD|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	7.04276e-51
NC_021985.1|WP_020943637.1|7434896_7436927_-|phosphoenolpyruvate-synthase	gnl|CDD|376527	pfam01326, PPDK_N, Pyruvate phosphate dikinase, PEP/pyruvate binding domain. This enzyme catalyzes the reversible conversion of ATP to AMP, pyrophosphate and phosphoenolpyruvate (PEP).	5.16562e-41
NC_021985.1|WP_020943655.1|7455418_7456276_-|MoxR-family-ATPase	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.22517e-43

Protein sequences

>NC_021985.1|WP_043476875.1|7446172_7446904_-|SigE-family-RNA-polymerase-sigma-factor
MTTATPPAALPWDRAAAPESGAPSWRRFRRALRPHVPRARVPRRRALCARVLARVGIGTAAGPAPSGRGDGTTAPALRAPSSPSGIEELYHHRRLSLVRLAVLLVDDVPTAEDVVQDAFTALFRRHGHRLGTLDDPEAYLRTSVVNGARSVLRRRRTVRAHTPEPERHAPAPEEDVLLHEDHREVLAALRTLTTRQREVLVLRYWSHLTEAEIAATLGLSRGTVKSTASRAIDALGRRLEGLR
>NC_021985.1|WP_020943645.1|7445837_7446176_-|hypothetical-protein
MSTSGTSTAAVEERLRAALDARARSVGPADLRPLRPPAATGRPRGTVPRRTAMGLLALAAVAALVFLAVRGGPDRPAEPAHRPRPPATGTPTPVPSPVRPTTAQPSPSVPGP
>NC_021985.1|WP_020943644.1|7444424_7445390_-|pirin-family-protein
MSNLDRAPVPSVCGGRGFVVAEPVRELLSPRHVKLGESTEVRRLLPNLGRRMIGAWAFVDHYGPDDIAGEPGMQVPPHPHIGLQTVSWLHEGEVLHRDSTGSLQTIRPKQLGLMTSGRAISHSEESPRSHARFLHGAQLWVALPDEHRHTEPMFEYHADLPTVTAPGLTATVILGGLDGSSSPGTTFTPIVGADLALTRGTDVRLPLERDFEYGVLAMSGEVHVDGVPVLPGSMLYLGCGRTELPLRAESDAGIMLLGGEPFAEELIMWWNFVGRTQQDIEQAREDWTTGSRFGEVKGYDGAPLRAPELPPVPLKARGRVR
>NC_021985.1|WP_043476872.1|7443100_7444138_-|C40-family-peptidase
MASHRRPKQPSRTRVTVLTTAAAAAVALSANAANAAPGEKLGKDEVKAKVDKLYEQAEQATEKYNGAKEKQQKLQKEISTVQDNVARGQQELNKLREGLGSMATAQYRSGGIDASVQLFLSSDPDDFLDKASTLDQLSSQQVEALKKIQDKQRELAQERAEATEKLKDLASTRTELGNKKKEVQGKLAEAQKLLNTLTAKEKAALDAEQQRANRSSTERVELKDAPPASGRAGAAFSAAQSQIGKPYVYGATGPSSFDCSGLTSWAYAQAGVSIPRTSEAQSGIGTRLTRSQLQVGDLVFFFNDLHHVGLYAGNGQVLHAPRTGTVVRYESMDTIGGPFMFGVRV
>NC_021985.1|WP_020943642.1|7442647_7443058_+|hypothetical-protein
MSRRDRGSRRAPAAAPAPCAVTVCRGCCCGTEKVPGVDHAAQLALLRQSLSGAAQVRVTGCLDACEQANVVVVQPSAAGRAAGGRPVWLGLVHDTDAVRDIAAWITAGGPGLADPPGVLDLYAFTPSRRVRQSVED
>NC_021985.1|WP_020943641.1|7440638_7442651_+|heavy-metal-translocating-P-type-ATPase
MSSTLTRPAPPGAARESVAPRRRTRLLALPEARWAAAALVLFLIALPLYLAGAPAWTWGTLFAAVYATGGWEPGRAGLRALREKTLDVDLLMVVAALGAAAIGQVLDGALLIVIFATSGALEAIATARTADSVRGLLDLAPATATRVADDGTEETVPGERLAVGEIILVRPGERIGADGRVLDGAGEVDQATITGEPLPVAKAAGDEVFAGTLNGTGALRVKVERDPSDSVIARIVAMVEEASGTKAPTQLFIEKVEQRYSLGMVAATVALFVLPLLVGADLRSTLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVMERLGQVDAVALDKTGTLTEGTPRVTDVRPLPGPGLPEDEVLRLAAAAEHPSEHPLARAIVDAARDRGLDIPLVRDFGSAPGTGVSATFEGRSVAVGSPARLPDGRTGGPAGEEAAAPEMTRALDVAAALEEEGRTAVLVTVDGRPAGVLGIADRLRDEAAATVAALGELAGTTPVLVTGDNPRAAARLAGEVGIDDVRAGLLPQDKVAAVREWERAGRKVLVVGDGVNDAPALAAAHTGIAMGRAGSDLALETADAVVVRDELATVPAVVRLSRRARRLVVQNLVVAAVFITGLVIWDLAGTLPLPLGVAGHEGSTVIVGLNGLRLLADGAWRRAHAGTDR
>NC_021985.1|WP_043479540.1|7440128_7440530_-|winged-helix-turn-helix-transcriptional-regulator
MGHGAAQPSGRVPRRNLDAASAAKVATTLQALATPSRLLILARLREGSLPATELAAEVGMEQSACSHQLRLLRNLGLVVGTRKGRSIVYSLYDNHVAALIDQAIYHVEHLRLGLTDSAALTEAEEEGAGVPSA
>NC_021985.1|WP_020943639.1|7438536_7439823_+|PAS-domain-containing-protein
MDEADLKTLLAPLPVSWWEADGGARLVESGGGAFADERTARRFLRALCAEAGGAARLPADGPYRARFEGRTFDVNWPAHEGGTATGRSRGVAVEVAGAAAGTGPYASFADLSPAAVFVRDTDGRCVWANHAYAHLYGTTRDALIGRHLAEIDGADDAARFLALDEQVLSGGHSARHTLAFRHTDGSAGHAVGYRFPVHWGTRRCVAGIYVDITDYTRALEQRRRAEADLCALRDHSGLACLRLSADGVVRDAGTAAAEVLHVRLGDLLGSPADTLLARTPERTALHRVWDDLIAGRRRSARTSAVLVDGDRRRRAWIHLSAVQHAAEHLPGVWAVITRLGLSHEAHPPLTPAQVRILALLAAGHSNADVAGALHLSRQTVDYHLSRLRRLLGVATRPALVARAYALGILSPHAWPPRSTTATHPLSPA
>NC_021985.1|WP_020943638.1|7436923_7438297_-|ATP-grasp-domain-containing-protein
MTKVLYVHAKGGPPVGYALPRVAARSTVHLLALSDLPADMAADPARLCASVLARGDADEHDLVELISSRAREVGADAVITFSEYAVVAVAEAARRLGLRGAGPTAALARDKRLMRAAWERRGIPQPRFRAVATEEQLAAAAIELTCPLLLKAAWSAGSTAHQIIEGPADVAGAWKRSRAVMSESALLGYAELHVGGAGEDFVVEEIVTGCAEEWFDGTGWGDYVSVEGAVVGGVFRPVCLSGRMPTVAPFTERAGITPAAVGARAQARIVELARQAVEALGLQDCGTHTEIKLGADGRMWVIETAARFGGAMTVPQIEEVFGLDLVGMFTDQLLGRAAGWPARALTPEDAEGAAGSLVVLAVDGAGAPWRRRHVWDSASVLRSVPAGAASTLSVVRESSLPDGTPVPVYDPAAGANTMAGLCLMSADRPQTVIRDFTALVDALPRILPAYVGEGVRA
>NC_021985.1|WP_020943637.1|7434896_7436927_-|phosphoenolpyruvate-synthase
MTATLDEAGVPGTAGDRTVVGANLSLPLFRTLSGVLAGHPYLKIVVDRAERTWHLLDTRVHPFHVDYIATRVLGLTMAELDADLDAFNASVYMAPERRFLLGVLSLHAEQEPDGTERPFLVLETTEADTMQGPLLEEFYSYVRERVDGRLPLLLKPANHGQEQELTAIGEARVPRVLSHELFGNRTRTCLNPGEAEGRLRHFRTAAEYEAVAAELGWSDIVAMPRLPDDVPRVAGFINTAPITPLSHTNVLASGWGIPNAVVRDLDTLLRDSGLDGPDGLDGAWVRYRVREDSVTLEPLPGRPELTRPAWHQQRIRIGTPLLRQAPVLALDRLRRTDRDSYGTKAANLGELHHVLDSRTADLTAFYARPRPPRPHLLGHLGARLGEPGASAAELRAAAAAYVAATVRAPRGVALPFHLHHLFLTSSPALQQGIGKLKMALELEAFDLVDPLCLNLQHLVGCTPMPDEVASAITGAVPELLAGGSRMVARSSSNAEDLPGFSAAGIYDSVTTVRGAEQLLAAVRQVWASLLSPRSVRLRHQAGISLDDTYMGVIVQEYVPAALGGVLVTCDPTRREDFRNVYVNCTPGSPERVVDGTVLPQQYLYNTVEGGGRTVDVGSTGEDLPSPTRLALARLALTGRLLQSHFGADDPDDALDIEWLMTDQGAFHLVQIRPYAR
>NC_021985.1|WP_043476881.1|7447655_7448351_-|type-1-glutamine-amidotransferase-domain-containing-protein
MSKILFVLTGADRLTLADGSQHPTGFWAEEAVVPYRALKAAGHEIVVATPGGTPPPVDRASLAAEVNGGQERADEIARGLEEMTELGEPVKLAEADLDDFAAVFYPGGHGPMEDLAVDEDSGRLLVAALDSGRPLAVVCHGPAALLAAVRADGANAFAGRPVAAFTNEEETQGGLAPRVRWLLEDRLTEAGVDVRTAAPWAPHVVVDGNLITGQNPASSAQVAEELLKRLG
>NC_021985.1|WP_043479543.1|7448480_7449398_+|LysR-family-transcriptional-regulator
MLGGVDTPSLDLNLLRTFLAVYRSGSFTGAARLLGLSQPTVTTQMRALERLSGRELFERLPRGVTPTQVADELAARIAAPLDELAAVAGPGPLEGARPEPVHLAGPAEFLCTQVMPALAPLVAEGVRLRVATGLTEPLLEELRAGRHDLVIATARPRGRALHAVPLGDEEFVLVAAPVWAERLAGRLPAEGPAALQSVPLITYAEDLPIARRYWRHVFGRRLSHTAAVTVPDLRGVLAAVAAGAGFSVLPRYLCAEPLRSGALVALLEPEDAPINTGYLVQRPGASENPDVVRVRELLVREGRTW
>NC_021985.1|WP_020943650.1|7449440_7450025_-|HD-domain-containing-protein
MSAATIATGETDPPLRALPERAAAVLAGVDAPPRLVAHLRAVHDVAARLVEWVRLRCPVLELDAEAVLFGAATHDIGKALHPAELSGPGARHEEAGRELLLGHGVEPRLARFAGTHASWTAPGTGAEDLLVSLADKVWKNKRVTELEDLVVALLAGADGRAAWEWFMELDEVLTEIGDGADRRLAYQMSHPLTR
>NC_021985.1|WP_020943651.1|7450208_7452089_-|glycoside-hydrolase-family-47-protein
MATPPAPGHPAGPANTRLTRRALLRSAAGATAALCALGGPGAAPASAAPGPADPALAEDVRQEFLTAWTAYRRLAWGRDELHPVSGTGSEFFIDSVPLGLTVVESLDTLFLMELDGELDAAVSWIGTRLDFDRDANIHVFEAIIRLVGGLLSGHHCTGDPVLLTKARDLADRLLPAFTSSPTGAPYRYVNLRTGAVSGEQVPLAEIGSNITELGCLSRLTGDRRYLDAAKKALRAPYDRRSALDLVGTTLNVETGGWTDPTARVDPPVDSYFEYLWDAYQFLGDTEIRGWYRTLTSAVLRHLGETRDGRLWFRSADMHSGATTGLGQSELAAFYAGLLAQGGDLAAGESYHSSWAAALTRFPVPPETIDRTTLAATSTQYRLRPEYADSALFLWLLTGKELYRERARWLWDAQRAHCKVPDGYTIVADLRTTPVTRGDLTPGYWFSENMKYFYLLWSGTPRFDYTTNYLTTEGNVLRGAHRVPAPSPSGTFRLLNRATGRAMAVRGASTADGAPVVGRAPGAGADQRWIVTTSDGHTRLTSLHSGKVLEVPRSSTIDGTALHQRAHDGTRGQQWTVQPARDGYQRLVNRHSGKALDVDGTADGAAVVQRTTGGAASQQWRLVAGEG
>NC_021985.1|WP_020943652.1|7452569_7452926_+|cupin-domain-containing-protein
MLEVKTVDKPDERRDFPRGHLEALHLTGLDFAVGTFEPGWRWSESVGPIAGTASCMVHHNGYVVQGRMHLRMDDGGEGEVGPGDVFVCPPGHDAWVVGDEQVVLYDFAGTMANEYAKS
>NC_021985.1|WP_020943653.1|7452943_7453924_-|pyridoxal-phosphate-dependent-enzyme
MSHPPVQLATFPTPAEPAPRLAAAIGLGPDDLWIKRDDLTGTGGGGNKIRKLEWTVGAALAEGADTLVTTGAPQSNHARLTAAAAARLGLAAVLVLRGSPGGSGSGNLALDGLLGARLVWAGDVDRAGLDAAAAEVCERLRASGARPALIPFGGSSALGARGYVRCGEELRAQVPGLRTAVVALGSGGTMAGLVVALGSGAVLGVDVGALADPAAAVREFAAPHTDGDVTADGLRVRRDQVGAGYATLTGPAAEALRLAARTEGIVLDPVYTGRALAGLVAAVRDGDVRPGERTVFVHTGGLPGLFGHAEAVAYAEAGAGSPPAGP
>NC_021985.1|WP_020943654.1|7454060_7455422_-|VWA-domain-containing-protein
MTGVDGRITGLVGALRAHGVRIGTGETVDAALAARELGFADRELLREGLAATLLHGAAQRAVFDPVFDLYFPRGVGAPVGAADDQGADRENLRDRLAAALAADDRSLLAALAAEAVDGFGGYGGSSGSDGWSAYQALDRIRPQTLLARVRADVRARDGGAGFADRLLDDEIRRRIEEFRRLVGADARRRIAERRGRDEIARRAVAPTADRVDFLYAGRDQLAELRRTVQPLARKLATRLAARRRRAARGTVDLRRTVRSSLSTGGVPMRPVLRRRRPVRPELVLLCDVSGSVSGFSDFTMLLVQALHDQFSKVRVFAFVNRLDEVTGLLGRGQADPDGLGARIRAEATLTGWHGSSDYGVALGEFAERWDAAVGPRTTVFVLGDARTNMSDPNLPAVRELARRARRVYWLNPEPRAQWGTGDSAAPDYAGLVEMHECRTARQLGALVARLLPV
>NC_021985.1|WP_020943655.1|7455418_7456276_-|MoxR-family-ATPase
MFSSVDDVSARLAVTGYLASPAVATTAFLAARLGKPLLVEGPAGVGKTELAKAVAEVAGARLVRLQCYEGVDESRALYEWNHAKQLLRISAGRDESWDETRTDIFGEEFLLPRPLLTAIRGDEPTVLLIDEIDKADVEMEGLLLEVLSDFQVTVPELGTITATRRPFVVLTSNAGRELSEALRRRCLFLHIDFPEEELERRIVRLKVPDLDEALAASVVRVVGALRAMDLRKAPSVAETVDWARTLLVLGAGALDETVVRDTLGVLLKHQEDVRKAAAKLDLAAL
>NC_021985.1|WP_020943656.1|7456430_7457003_+|TetR/AcrR-family-transcriptional-regulator
MTTTDKASPRDRLLDAAAQLVYREGVSVGVEALCRAAGVSKRSMYQLFGGKDEMLAASLERQIPWYEARLAPADPDSGTPRERILHVFEQVEKASADPGYLGCPYLAVLVELKDPGHPASEVARTVKARLEHGLRTQAELGGARDPGLLARQLMLVFDGASARAGARVEHLDDGLTTTTVTALLDAAGMR
>NC_021985.1|WP_020943657.1|7457069_7457750_+|ABC-transporter-permease
MIPTPHDCLARNEWICGAYLSTRRRILLDAVVQHVQLTAVSVLIGLVLAVPLAVLARRLPPASGPVLAVTTVLYTIPSLAMFSLLLPLYGLSASLVVAGLVLYSLTLLVRNILAGLRAVPEETRQAARGLGYGPVRLLLTVELPLALPAAMAGLRIATVSAVSLVTVGAIVGFGGLGNLIYAGMNSYFKAQVLTASVLCVVIAVAADLLLLGVQRLLTPWTRAARA

Crispr_ID: NC_021985_18

• CRISPR_ID: NC_021985_18
• CRISPR_location: 7487547-7487637
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_18

Consensus_repeat	Method
TCAGGCGGTCGGCTTGGGGCCGTCGGC	CRISPRCasFinder

spacers of NC_021985_18

>18.1|7487574|37|NC_021985|CRISPRCasFinder
CGCGTGAGCGCACGGGCCGTGGCGCAGGTGCGCCTCG

CRISPR arrays and Neighbor proteins around NC_021985_18

CRISPR arrays

The CRISPR arrays of NC_021985_18

>merge|NC_021985|18|7487547-7487637|CRISPRCasFinder
TCAGGCGGTCGGCTTGGGGCCGTCGGCCGCGTGAGCGCACGGGCCGTGGCGCAGGTGCGCCTCGTCAGGCGGTCGGCTCGGGGCCGTCGGC

>NC_021985|18|15|7487547-7487637|CRISPRCasFinder
TCAGGCGGTCGGCTTGGGGCCGTCGGC	CGCGTGAGCGCACGGGCCGTGGCGCAGGTGCGCCTCG
TCAGGCGGTCGGCTCGGGGCCGTCGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020943680.1|7483447_7484701_-|FUSC-family-protein	unknown	unknown	gnl|CDD|226614
NC_021985.1|WP_020943677.1|7480325_7481054_+|DUF2470-domain-containing-protein	unknown	unknown	gnl|CDD|378456
NC_021985.1|WP_020943688.1|7492146_7493163_+|DNA-topoisomerase-IB	unknown	unknown	gnl|CDD|226099
NC_021985.1|WP_020943676.1|7479651_7480257_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NC_021985.1|WP_020943692.1|7495687_7495882_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043476889.1|7488002_7489034_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187551
NC_021985.1|WP_020943681.1|7485063_7485558_-|FBP-domain-containing-protein	unknown	unknown	gnl|CDD|379860
NC_021985.1|WP_020943679.1|7482331_7483402_-|hypothetical-protein	unknown	unknown	gnl|CDD|237057
NC_021985.1|WP_020943678.1|7481021_7482221_-|lactonase-family-protein	unknown	unknown	gnl|CDD|378416
NC_021985.1|WP_020943675.1|7478011_7479532_-|cytochrome-P450	unknown	unknown	gnl|CDD|365848
NC_021985.1|WP_020943687.1|7491335_7492139_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|237187
NC_021985.1|WP_020943682.1|7485876_7487166_+|ROK-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224851
NC_021985.1|WP_043479554.1|7490092_7491133_-|PHP-domain-containing-protein	unknown	unknown	gnl|CDD|236135
NC_021985.1|WP_020943673.1|7476109_7477015_+|RNA-polymerase-sigma-factor-SigJ	unknown	unknown	gnl|CDD|236600
NC_021985.1|WP_043476891.1|7493207_7493453_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020943691.1|7494794_7495442_-|VanZ-family-protein	unknown	unknown	gnl|CDD|377417
NC_021985.1|WP_020943674.1|7477120_7478050_+|pentapeptide-repeat-containing-protein	unknown	unknown	gnl|CDD|224276
NC_021985.1|WP_020943683.1|7487705_7487975_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020943685.1|7489373_7490030_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|223620
NC_021985.1|WP_020943690.1|7493462_7494695_-|family-16-glycosylhydrolase	unknown	unknown	gnl|CDD|185693

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020943680.1|7483447_7484701_-|FUSC-family-protein	gnl|CDD|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	4.67418e-15
NC_021985.1|WP_020943677.1|7480325_7481054_+|DUF2470-domain-containing-protein	gnl|CDD|378456	pfam10615, DUF2470, Protein of unknown function (DUF2470). This family is a putative haem-iron utilisation family, as many members are annotated as being pyridoxamine 5'-phosphate oxidase-related, FMN-binding; however this could not be confirmed.	1.34389e-09
NC_021985.1|WP_020943688.1|7492146_7493163_+|DNA-topoisomerase-IB	gnl|CDD|226099	COG3569, COG3569, Topoisomerase IB [DNA replication, recombination, and repair].	1.54513e-61
NC_021985.1|WP_020943676.1|7479651_7480257_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.37147e-09
NC_021985.1|WP_043476889.1|7488002_7489034_-|SDR-family-oxidoreductase	gnl|CDD|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	7.21575e-95
NC_021985.1|WP_020943681.1|7485063_7485558_-|FBP-domain-containing-protein	gnl|CDD|379860	pfam16571, FBP_C, FBP C-terminal treble-clef zinc-finger. FBP_C is a family from the C terminal end of fibronectin-binding proteins. It forms an extended four-cysteine zinc-finger with a unique structural fold. Fibronectin-binding proteins bind to elongation factor G - EF-G, which is mediated by the zinc-finger binding to the C-terminus of EF-G. FBPs release ribosomes by competing with them for EF-G.	9.61578e-86
NC_021985.1|WP_020943679.1|7482331_7483402_-|hypothetical-protein	gnl|CDD|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	0.00153956
NC_021985.1|WP_020943678.1|7481021_7482221_-|lactonase-family-protein	gnl|CDD|378416	pfam10282, Lactonase, Lactonase, 7-bladed beta-propeller. This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyze 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.	7.71852e-133
NC_021985.1|WP_020943675.1|7478011_7479532_-|cytochrome-P450	gnl|CDD|365848	pfam00067, p450, Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.	1.08051e-73
NC_021985.1|WP_020943687.1|7491335_7492139_+|SDR-family-oxidoreductase	gnl|CDD|237187	PRK12743, PRK12743, SDR family oxidoreductase.	2.22341e-153
NC_021985.1|WP_020943682.1|7485876_7487166_+|ROK-family-transcriptional-regulator	gnl|CDD|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.61874e-49
NC_021985.1|WP_043479554.1|7490092_7491133_-|PHP-domain-containing-protein	gnl|CDD|236135	PRK07945, PRK07945, PHP domain-containing protein.	0
NC_021985.1|WP_020943673.1|7476109_7477015_+|RNA-polymerase-sigma-factor-SigJ	gnl|CDD|236600	PRK09636, PRK09636, RNA polymerase sigma factor SigJ; Provisional.	1.6578e-86
NC_021985.1|WP_020943691.1|7494794_7495442_-|VanZ-family-protein	gnl|CDD|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	4.27522e-26
NC_021985.1|WP_020943674.1|7477120_7478050_+|pentapeptide-repeat-containing-protein	gnl|CDD|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	1.00354e-15
NC_021985.1|WP_020943690.1|7493462_7494695_-|family-16-glycosylhydrolase	gnl|CDD|185693	cd08023, GH16_laminarinase_like, Laminarinase, member of the glycosyl hydrolase family 16. Laminarinase, also known as glucan endo-1,3-beta-D-glucosidase, is a glycosyl hydrolase family 16 member that hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans.	1.92487e-96
NC_021985.1|WP_020943685.1|7489373_7490030_-|HAD-family-hydrolase	gnl|CDD|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	3.25058e-38

Protein sequences

>NC_021985.1|WP_020943682.1|7485876_7487166_+|ROK-family-transcriptional-regulator
MAGRNGRTVRDLRRGNRTAVLQRLYFDGPLSRFELGPATGLSSGSVSNVVADLVADGLVEEAGSVDSDGGRPRTLLRVAPHSGQMIGVDVGETRVRVELFDLGLTELARAERPLTQQGYDVDVIVGHIRDGIAEVLAAEAAVPERLLGVGVGVPGIVEHTADRGAVVHGQTIGWSAVPLEELLRASSRLPDSVRYFIDNGAKTLGQAEMWFGAGRGARNAVVVLFGSGVGACLVTPDVEHGRAVEWGHLTVRVRGRRCRCGAPGCLEAYAGAESLLARWREEGGRPPEGVDEETALTAMLAAAYPAGDGDPDPVALAVLEETAEYLGAGLSDLINLFQPEKILIGGWAGLQLGTRFLPAVRRHASTYALRHPADKVGIDLGRLGPDAVTVGAAILPLADFFTRGGRRAEPAAADRHPAWRAALEERAPR
>NC_021985.1|WP_020943681.1|7485063_7485558_-|FBP-domain-containing-protein
MRPLTEQDIRGSFVNCSKGEAKRLAVPRDLGERPWDDLDFLGWRDPGAPDRSYLVVEREGRPVGVALRFPVSRRGFLHRSMCSVCLTTHPGGGVSLMTARKAGTAGREGNSVGVYMCTDLQCPLYVRGRKVPDSGARLEESLTLGEQIARTARNLSAFLDKLYV
>NC_021985.1|WP_020943680.1|7483447_7484701_-|FUSC-family-protein
MLDVRKWTAELRRLILRRREPVVVQTLRSATAATIAYVIALRLSPEPAPLTAPLTALLVVQVTFYATLTNGIRRVNSVVAGVLVAIAFSLLVGLTWWSLALLIVASLAVGHLVRVDEYVAEVAISAMLVLGVTTVGFTAWARIVETLIGAVVGMACNLLLPPPVWLDQAGQSIEDLARRIRQLMLRTGEEAAGRTPWELAAERLHEARRLDHDIVQVDAALRQAEDSLRLNPRVKEGLLHRVVLRTGLDTLEICTVVLRVLARTFTDLAKARGSEELFPPRVGALVEQLLAEIADAVVSFAVLVTTHLSENAESAEARLTAELHSAAGTRDRLAELLREEVRADWENWQLLGAVLTEANRMIDELDTEHRTRRLFEELDRVSREQRVKLPRMTRVRERLGVQDQLWRNRTGVGERSP
>NC_021985.1|WP_020943679.1|7482331_7483402_-|hypothetical-protein
MAGSGVRIDGNTLRLPGGVAVRFIRTLRLPETGTHPLPPGLGEFPVRRVADHADRVPEEWRARGGVMLPVYLREAMWLSFAGTAEPAALQVGVGKVCAVSGEPWRGRPARDPQNYVVLPRQPWLDGINSGKGTVRQFVAVPLGLGATVEGQVTGEEVWGGVQLQSFPLRPDVLADWRLRERERERSMPAPGGYGGPMPVAGFGAPAPMAAPAPGGPPPAPAAAGAPPRRAAAMGLGVGGSMRQEVYRDDRPLSDWAETPAGRVFVHLVTPPEWRRITGEAPPPSPVDRAAYTSAGLPWFDYYDEDAADLDPTDTLGGVKPVGDWLGDDLDPWQQPSAGQVLPLKDAPGKPVEDGDW
>NC_021985.1|WP_020943678.1|7481021_7482221_-|lactonase-family-protein
METDARAARAGWSRRRFVGAAAGTAVVVAVPAPAAPPAERAPAARERPAARPPRRDDRRRPLLLGTYTSAEGGGSGIGLASYDPATGAVTGAGTLARVPDPSYLAAHPDGRTVYAVDERPDGAVSAVRLADRRVLGSRSTGGAGPCHLSVHPSGRWLLSADYGSGSVAVHPIDATGALGERTDRVTHTSPPPGPGQQGPHAHQVVTAPDGGHVLAVDLGTDTVYTYRLDQAKGTLTEVARARTRPGAGPRHLTFHPDGRHAYLANEVDDTVTVCGYDPATGRLTIGAPQPTGSGGGTNYPAQILVTANGAYAFLANRGDNSIARYAVEEGGAALRLLGTVPAGGDFPRQIAFSPDGRLLFAANQRSGTVTVFRVDPDTGELRAAGEPFASPVAVCALPL
>NC_021985.1|WP_020943677.1|7480325_7481054_+|DUF2470-domain-containing-protein
MGDTQDWAAGPGAAQRARSVLATAWSCAVTADGAREEYVGAHTVTEDGGVLLDAPEDGALVTAALCAPRGEPSAVLEFADAAPVPVRDRIRARVWLAGWFTPVAGGPLLFRPTRVVLRRPSGAVLVDLAEFAAARPDPLAAAEARLLTHLAAAHPDAVERLTRLVRPESLHAATRVTPLAVDRHGLTLRVERVRAHGDVRLAFHAPADDVTQLTERMHALLARASAAACPRALQRQRADGDG
>NC_021985.1|WP_020943676.1|7479651_7480257_+|TetR/AcrR-family-transcriptional-regulator
MPANQGERTRRRLSTGERREQLLSVGAKLFSESPYDDVLIEQVAEIAGVSRGLLYHYFPAKREFFAAVVERESERMLRMTAAVPGMPVREQLTAGLDTYLAYVQAHAHGFRAFHRADAAGDQAVRRVYRRALAAQEAQILAALAADPEFGSAFAGTPRVRLAVRGWLAFTTAVCLEWLRDGELTREQVRDLCARALLGVIV
>NC_021985.1|WP_020943675.1|7478011_7479532_-|cytochrome-P450
MAETTEAGLPKGFRSAEQGWPALRRIPHPPRRVPLLGDVLGVDRHRPLQDSMRFARELGPVFRRRVFGNEFVFLWGSRLVADLSDESRFAKHVGLGVANLRPVAGDGLFTAYNHESNWQLAHDVLAPGFSREAMAGYHGMMLAVAARLTGHWDRELAAGRPVDVPGDMTKLTLETIARTGFGHDFGSFERDRPHPFVRAMVGTLTYAQRLNSVPVPLAPLLLRGPARRNAADIAHLNRTVDGLVAARRRSGGGDGDLLDRMLATAHPETGERLSAENVRKQVITFLVAGHETTSGALSFALYYLARHPEVAARARAEVDRVWGDTAEPGYDQVAKLRYVRRVLDESLRLWPTAPAYAREAKQDTVLAGEHPMRRGAWALVLLPMLHRDREVWGEDAERFDPDRFEAGAVRARPPHTFKPFGTGARACIGRQFALHEATLVLGLLLRRYDLRPEPGYRLRVTERLTVMPEGLRLRLERRPAPAPAPVTVPDDGPGSAARCPVRGAGD
>NC_021985.1|WP_020943674.1|7477120_7478050_+|pentapeptide-repeat-containing-protein
MPEQTTDRSALRGDCAQCFGLCCVALPFSASADFAVDKPAGRPCANLRGDHRCGIHAELRAKGFTGCTVYDCFGAGQKVSQITFGGQDWRTGPAEHARRMFDTFPVVRQLHELLWYLTEALGLEAARPVHPDLRRALEETERLTRGTPQELAALDVAAHRQEVNVLLLRTSELARAGVPAPEGKPDTGGHGRSGKGGNGRNGKAGKSGKSGKSGARDRRNADLIGARLRGADLRGVSLRGAYLIAADLTGADLRDADMIGADLRDADLTDADLTGAFFLTQPQVNAARGSAGTRLPGSVTRPAHWTAGG
>NC_021985.1|WP_020943673.1|7476109_7477015_+|RNA-polymerase-sigma-factor-SigJ
MNGDTGGTELLAGRFEEHRAQLRAVAYRMLGSLPEAEDAVQEAWLRLGRTEADGIRNLGAWLTTVVGRVCLDLLRSRTARREEPMADTFVPDPLVRPLPRVDPEAEALEADSVGLALLVVLETLEPAERLAFVLHDMFAVPFEDIAAVVERTPSATRQLASRARRRVRGATPAADPDLGRQREVVDAWLAASRAGDFDALLAVLHPDAELRADAGALVRGAAASKAVRGARTVAGQASMFWRYAVFARPVLVNGTVGLVTAPEGKPVSVTAFTVADGRITGIYILADPDRLARLALPVPGS
>NC_021985.1|WP_020943683.1|7487705_7487975_-|hypothetical-protein
MTAQRDPESGQPVRPVPRDLPDQQARPGGDPWDAAARPASRNEPAPPEDDTEPDAPDTDEAGSGPRNGPPAQTDQQTPTDEPTPEEPTA
>NC_021985.1|WP_043476889.1|7488002_7489034_-|SDR-family-oxidoreductase
MSSATGSRVVVTGATGNVGTSVVRLLSEDPGVKSVRGLARRRPEWSPEKVEWGTVDLASETANLAERFEGADAVVHLAWAFQPTHDPVATWRTNVLGSMRVFEAVAAARVPVLVHASSVGAYSPGPKDHAVDESWPTHGWPDAAYCREKAYLERALDTFERDHPEVRVVRMRPAFLFKWESASEQRRIFGGRFLPGPLARPEVLPFLPDIPGLRVQALHTDDAAEAYRLAVHSETARGAFNLAADPPVDAALLGELLGTRPVRLPRTAARSAIAAAWGLRLLPASPHLFDAVLRLPLMDCARAHTELGWRPRRTADEVVREFLEGLRKGGGMETEPMRGRKVG
>NC_021985.1|WP_020943685.1|7489373_7490030_-|HAD-family-hydrolase
MDRAAVFDVDGTLVDTNHLHVVTWWEAFRQAGHRVPMHAVHRAVGLGSTDLIAHLLGDDRDEEQDATLNAAHKALYGQYFDRLPPLPGAGELLRRLHRDGWRVVLATSASGAELGALRRAIDADEAIDGTASADDVERGKPAPEPVEHALELAGVPASRAVFVGDTVWDMRAGGKAGVHCVGLLCGGIPRADLEEAGARSVYADPADLLDRLDGSPLA
>NC_021985.1|WP_043479554.1|7490092_7491133_-|PHP-domain-containing-protein
MDPVAALDRIAFLLERSLAPTYRVRAFRTASRTLAALPEGEVGERVSAGTLESLKGVGPKTAQVVREALAGEVPGYLRKLEEEAGARESTGPGAELRALLRGDCHTHSDWSDGGSPIEEMGRAAIGLGHEWTVLTDHSPRLTVARGLSPERLREQLDVVAALNATWAPFRLLTGIECDILDDGSLDQEPELLERLDVVVVSVHSKLRMDAPSMTRRMVAAVRDPHADVLGHCTGRLVTGRGRPESEFDADEVFAACAESGTAVEINSRPERLDPPRRLLRAAVAAGVLFSIDTDAHAPGQLDWQILGCARAEECGVPAERVVTAWSAEELLAWTRQGRTPARVTAS
>NC_021985.1|WP_020943687.1|7491335_7492139_+|SDR-family-oxidoreductase
MPEPDTQRTAVITGGDSGIGRATAVRLAEQGLDVGITWHTDEKGARETAEEVRAAGRRAAVAHLDLTRLPGAADTVDELCAELGRLDVLVNNAGTGTMTPYLDLTLDDVRRVLDVDLVGPFLCGQKAARQMIRQGGGGRIVNVTSVHEHQPRVGAAPYCAAKGGLGLLTQVMALELAEHGITVNAVAPGEIATPMTGQEDVDPHTERRPGIPLGRPGDAREVAAVIAFLASPDASYVTGASWSVDGGMLRMGPQAGSHLTGDDWRRP
>NC_021985.1|WP_020943688.1|7492146_7493163_+|DNA-topoisomerase-IB
MRLRTSSCEQPGFTRVRCGRGFRYRDTDGEPLTDTGQLARVRALTIPPAWRDVWICPWPNGHLQAVGTDAAGRRQYLYHERFRAEQDKAKHVHVREVARALPELRDRVTTDLKGRGLSHNRVTACAVRLLDLGFFRIGSDRHTRNSETYGLTTMLREHVSCGRGEIAFEFPAKGGTRMVRALVDDQAYAVARALLRRPRGGDRFLAFRDRGGWHDLHGDDLNEALRRLSGTDVTAKDFRTWHATVLAAVAVAVAARGARATAAARRRQTARAVREVSHYLGNTPAVCRASYIDPRVFELFEQDVTIAPALARLGEHGDFGRPATQGAVEAAVLGLLDG
>NC_021985.1|WP_043476891.1|7493207_7493453_+|hypothetical-protein
MTEQGVPHIAHPRVQVLGVCPGRHGEPPFRIMEIDGEVIGEARTVTDVLEAAASHGIPIHDLDDPDAVRWVGGGKYTWTLH
>NC_021985.1|WP_020943690.1|7493462_7494695_-|family-16-glycosylhydrolase
MASPRLLRSCLFAALSAALVGSVATGPARAQTTAPAAAAVSTFSDSFDGPAGSAVDSSKWTLETGDNVNNHERQYYTSGTKNAALDGQGHLVITARKENPAGYQCWYGSCQYTSARLNTAGRFDAQYGHVEARMKIPRGQGMWPAFWMLGTPVNWPDSGEIDVMENVGFEPSTVHGTIHGPGYSGSGGIGAGYSLPGGQAFADAFHTFAVDWAPDSLTWSVDGTVYQRRTPADLGGRTWVFNKPFFLILNLAVGGYWPGDPDGSTPLPAQLVVDSVSVTTSASATGVPIRGLAGKCVDVAGADPANGTPVQLYDCNGTAAQSWTVGADGTVRALGKCLDVTGNGTADGSTVQLWDCTGGPNQKWAVSAAHDIVNPQANKCLDVTGNNPANGTRLQIWSCSGGANQKWTVG
>NC_021985.1|WP_020943691.1|7494794_7495442_-|VanZ-family-protein
MARTALNLPAALRRPTKRGRDGEARPERVRPGEDRRGGRGVLARARVGRKRAGEARPGPGRHVLPLPLRLLAMLVAFAFMVAFAVVLARLTLQPSPASVALTHSNLHPGSSLRAYVDHGQFRDTVKQIGGNVLLGVPFGVLVPVLAPRARGVLHVVALTALVMLMVELVQGALITGRAFDIDDVILNTTGALLGWLFLGRRLGRAVHAREPQPAD
>NC_021985.1|WP_020943692.1|7495687_7495882_+|hypothetical-protein
MTRRTDPRTLLLAAAELLAWWAGLALLWLVFITSVDTLERVVGASAAAAAAVLARAGRRAVTWR

Crispr_ID: NC_021985_19

• CRISPR_ID: NC_021985_19
• CRISPR_location: 8102877-8102984
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_021985_19

Consensus_repeat	Method
GCTGCCGGGCAACACCCCCACCCC	CRISPRCasFinder

spacers of NC_021985_19

>19.1|8102901|60|NC_021985|CRISPRCasFinder
ACCCGCCACCCCGCCCGGCACCGCACCCGCCACCCCGTCCGGCGCCGCACCCGCCGGTGC

CRISPR arrays and Neighbor proteins around NC_021985_19

CRISPR arrays

The CRISPR arrays of NC_021985_19

>merge|NC_021985|19|8102877-8102984|CRISPRCasFinder
GCTGCCGGGCAACACCCCCACCCCACCCGCCACCCCGCCCGGCACCGCACCCGCCACCCCGTCCGGCGCCGCACCCGCCGGTGCGCTGCCGGGCAACACCCCCGCCCC

>NC_021985|19|16|8102877-8102984|CRISPRCasFinder
GCTGCCGGGCAACACCCCCACCCC	ACCCGCCACCCCGCCCGGCACCGCACCCGCCACCCCGTCCGGCGCCGCACCCGCCGGTGC
GCTGCCGGGCAACACCCCCGCCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_021985.1|WP_020937464.1|8110118_8111216_+|winged-helix-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|377630
NC_021985.1|WP_020937474.1|8096093_8096627_+|2'-5'-RNA-ligase-family-protein	unknown	unknown	gnl|CDD|379265
NC_021985.1|WP_020937467.1|8107499_8107904_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_078614862.1|8111891_8113628_+|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NC_021985.1|WP_020937471.1|8099535_8099904_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043477077.1|8095443_8095779_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043477068.1|8114186_8114618_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NC_021985.1|WP_020937477.1|8093300_8093504_+|cold-shock-protein	unknown	unknown	gnl|CDD|224197
NC_021985.1|WP_043477071.1|8105980_8106799_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|272862
NC_021985.1|WP_162473327.1|8113913_8114057_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_020937469.1|8105411_8105738_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NC_021985.1|WP_020937463.1|8111368_8111581_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_106960520.1|8094593_8094944_+|hypothetical-protein	unknown	unknown	gnl|CDD|375043
NC_021985.1|WP_106960518.1|8100018_8100645_-|anti-sigma-factor-antagonist	unknown	unknown	gnl|CDD|132914
NC_021985.1|WP_020937476.1|8093972_8094332_-|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_158506727.1|8096999_8097170_+|hypothetical-protein	unknown	unknown	unknown
NC_021985.1|WP_043474429.1|8108116_8108833_+|DUF1345-domain-containing-protein	unknown	unknown	unknown
NC_021985.1|WP_020937465.1|8109106_8110060_+|potassium-channel-protein	unknown	unknown	gnl|CDD|223643
NC_021985.1|WP_158506725.1|8098808_8099423_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225107
NC_021985.1|WP_162473328.1|8097642_8098365_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_021985.1|WP_020937464.1|8110118_8111216_+|winged-helix-DNA-binding-domain-containing-protein	gnl|CDD|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	4.21819e-45
NC_021985.1|WP_020937474.1|8096093_8096627_+|2'-5'-RNA-ligase-family-protein	gnl|CDD|379265	pfam13563, 2_5_RNA_ligase2, 2'-5' RNA ligase superfamily. This family contains proteins related to pfam02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.	5.28921e-07
NC_021985.1|WP_078614862.1|8111891_8113628_+|SpoIIE-family-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	8.80932e-30
NC_021985.1|WP_020937465.1|8109106_8110060_+|potassium-channel-protein	gnl|CDD|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	6.21914e-32
NC_021985.1|WP_043477068.1|8114186_8114618_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.50753e-11
NC_021985.1|WP_020937477.1|8093300_8093504_+|cold-shock-protein	gnl|CDD|224197	COG1278, CspC, Cold shock proteins [Transcription].	5.77576e-32
NC_021985.1|WP_158506725.1|8098808_8099423_-|helix-turn-helix-domain-containing-protein	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.44303e-38
NC_021985.1|WP_020937469.1|8105411_8105738_+|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.43139e-14
NC_021985.1|WP_043477071.1|8105980_8106799_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	4.77603e-86
NC_021985.1|WP_106960520.1|8094593_8094944_+|hypothetical-protein	gnl|CDD|375043	pfam17196, DUF5133, Protein of unknown function (DUF5133). This protein of unknown function is part of the Borrelidin synthesis genomic cluster. Borrelidin is a polyketide antibiotic.	0.00160736
NC_021985.1|WP_106960518.1|8100018_8100645_-|anti-sigma-factor-antagonist	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.96511e-25

Protein sequences

>NC_021985.1|WP_106960518.1|8100018_8100645_-|anti-sigma-factor-antagonist
MPGPRPAPSRSRPPLARSTVSRLRPAFFRSPRTPGRPEEVPAFPRRALAPAADNPGGQQKTRGERPPDKNTPRPVVAEHTGVLVNDTEGTLAISVHPSPAGPVVLRLAGELDHHTGARLGRAVEDLLHSPGPGPAPGIVADLSRLYYCDSTGITTILTAHDRARATGSSFCVAAPSPALAQLFRMTGLDQVLPFHPSVQDAVEALSND
>NC_021985.1|WP_020937471.1|8099535_8099904_-|hypothetical-protein
MREDAGLHCAQKPLFLINYRRPPTATDGLLSPTKGRSTAGALPGRPPQPPRPPVRPAGPPSALPALPALPALPALPALLLLLLQWADRGPDAAVAVAVVREAAGGGAGVWRRRLRAASGGRA
>NC_021985.1|WP_158506725.1|8098808_8099423_-|helix-turn-helix-domain-containing-protein
MTHLAVICDWPLLQLGLTQALEAQPDMRITTLASCVDEVALETADVEVILLINLQSRDQVTSREVARLYRQGHAVIVLSASGAPSDAVLCIKAGARGYLSRQTDACELVSAVRAVASGSDYFGASLAGRSIPAPPPHITGRERQILQFVADGATDREIAAKLNIAENTVHTHLERLRRKSGSRRRAELTRFALENGIIEDDLLE
>NC_021985.1|WP_162473328.1|8097642_8098365_-|hypothetical-protein
MRVAGAATLGAALGVAGTATLRTTLGVAGTATLGAALGIAGTTTLRPALGVTGTATLGAALGVAGTATLRTTLGVAGTATLRTTLGVAGTATLGAALSVARTATLRTTLGVAGTATLGAALSVAGTATLRPALGVTAAATLRTTLGVTAAATLRPTLGVTAAATLRPALGVTAATTLRPALGVTAATTLRPALGVTAATTLRPALGVAPLLGLLVAVVLARLVREQAVCLCTVADVPLSC
>NC_021985.1|WP_158506727.1|8096999_8097170_+|hypothetical-protein
MWSSALGGTSCARPVRAEETLDLDLDLDLGLVRIGGGRSELPVLRDRVLNISAGRL
>NC_021985.1|WP_020937474.1|8096093_8096627_+|2'-5'-RNA-ligase-family-protein
MRTVELLLDETAETAVRQAWRRLADAGLPSQARHPSPTNSPHLTLAACPELTAPIRWELAGAAAVLPLPVRFTGLVRFERPTSVLAWALDLDSALAGLHRRVWEAVASDSPPETLNPFHHPTRWSPHITLGRTRRPGAFTDRQIPGLLPAPPLSARLITLRSYDTDTGALEILTPRP
>NC_021985.1|WP_043477077.1|8095443_8095779_-|hypothetical-protein
MTAIRHLGRKSDVVLALRDADVIAAQLRQALAEASPQERPGLERAAALVESTAAASETRLRARWVRDRLAEAGFSGDITSVAAVKALRQAEPRLSLLAAVQLQKDAVTHPE
>NC_021985.1|WP_106960520.1|8094593_8094944_+|hypothetical-protein
MGAVACTLCVAPGTRDVGAALAAGRRRLTGARPQGYFLLAAPGAPPRRGDRPPWFLWLRWRRSSARRNGPGWSSGAGAWCVRQVAGSGPRPARSTDGLDRDPAARGLSAGSPAVEA
>NC_021985.1|WP_020937476.1|8093972_8094332_-|hypothetical-protein
MPKPDELIIDIAALVESGQSSQMSLTVVTGGAVITGRLAPEAMWRQRVREVLTDSAQLSDFSAVFDHPARQAGPPTHLHFHLARILQGPVGIPETGGMYRVAIDDVSAWTVGDFSYFDH
>NC_021985.1|WP_020937477.1|8093300_8093504_+|cold-shock-protein
MAAGTVKWFNAEKGFGFIEQDGGGADVFAHYSNIAAQGFRELIEGQKVTFDIAQGQKGLTAENIVLA
>NC_021985.1|WP_020937469.1|8105411_8105738_+|STAS-domain-containing-protein
MTTPLTLTSGRRPDGTVCLTVAGEIDMSNAGSLAEALDAHAGPVVVDLTGVEYLDSAGLSVLFAHADRLQLLVTPLLEPVLTVSGLTDLATVHALGPDHRPSPPRPCP
>NC_021985.1|WP_043477071.1|8105980_8106799_+|class-I-SAM-dependent-methyltransferase
MWATAVGVARVRALETERADPLFRDPLARAFAAAGGLWPSSPPPPQGDEAARRRRLAVAFSIVIRTKYLDDLLHQACASGIRQVVLLGAGMDSRAFRIDWPEDTRLFEVDTAQPLDFKDQVLRQEQAVPRCRRIPVAVDLREDWPQALAAAGHDPATPTVWIAEGLLIYLPRDAVDLLLSRIGARSAPGSRMGLTLGSRGVIERFGADAAPGSAASLWVSEMPDDPVGWLAGHGWDAETHTLRERAAAYGRPAGTPPSHEEGPGGLVSAVRR
>NC_021985.1|WP_020937467.1|8107499_8107904_+|hypothetical-protein
MRAGRRFSPLPRYRGVWAAGLTALPALFALSAVTPAAAAVPAHHQQAQPHPRYVQVSNTQTCNPDGLCTITATCPSGTVVTGGGVSETPLISSGVYLMETEPTSSRTWRGTLRNASQFPVQVTVTAVCARIPGV
>NC_021985.1|WP_043474429.1|8108116_8108833_+|DUF1345-domain-containing-protein
MARTRTQASTRHPRHERRGEARLPAVVATLAAIALYLLLPQRLLIAPRYVLPALECLLLIPLIAINPKRLTRQTKTFRVLSLTLVGVIAISNLVALAILIHELVYAGVKDGRSLLVAALQVWLTNIIVFGLAYWELDRGGPVSRTQAPRSALPLADFRFSQDENDDAVQEVADGASATSDWVPTLVDYLYVSTTNSTAFSPTDTMPLSTRAKAMMSIQSIAALLTSLLVIARAVSILH
>NC_021985.1|WP_020937465.1|8109106_8110060_+|potassium-channel-protein
MLLAAFALLALLAAGVGGYTLFGFSLPDAVYMTVMTLTTEGFSGADRLTEAGKLFTAALAVVGVALFVAVLGLIGTALVEGRFGPAGRKRRMQHRIDTLRDHFIVCAYGRVGQAVAREFEAEGVPFVVIENKTALEEQLQRERAPYLIGNAASEQVLRRAGIAHARGLVCAVDSDAENVYITLIAHSLNPSLAIVSRASEAASAERLTHAGASSVVSPYITSGRRMALLAVRPHVVDFLEFTRAGSSDVRIEEIRFDTGSRLVGRPLRQACGGALPLLIRRADGTLEPNPDPDTAVQAGDTMIVFGDPGALRPIEDD
>NC_021985.1|WP_020937464.1|8110118_8111216_+|winged-helix-DNA-binding-domain-containing-protein
MPEYDRVRLRRACAQALAGGVREATAEAVVRRVCALQAQDAMAADLGIRARGADITAPAVRAAYEDERSIVRGWYLRGTLHTVCSEDARPLLALLAPRILAATGRRYHQLGLHEELRRRADHLIRQVLSTHGPLTRAELTGHLTPLGIPPDGQAPFHLIRHAALTGVLCHGPRRAGEATYVLLDDWLPRGGGRREADGDAALAELARRYLAAHAPAGPQDFAVWSGLPLSWARRAWNTLARAAAITADGDLTTLAARAGKREYPPDAPGAPGAPDVRMLPALDNYLLGYRSREACVPAAHEADVWPGGGVIRPTVVADGLVVATWARRDAGRSITVRAFAPLPPGTRAAVDAETEDVSRFCRRSA
>NC_021985.1|WP_020937463.1|8111368_8111581_+|hypothetical-protein
MIVKKLHESGIRAEHAYAAAFVSIGLSVISWAASLQVEKKGEERADRWGIFVGEWAPTFFGLGLALSTYE
>NC_021985.1|WP_078614862.1|8111891_8113628_+|SpoIIE-family-protein-phosphatase
MSASADAGMDRFARLVANVLDVPVALVALAEDGRQVFPGMAGAGRPWSVSRQAALADSLCALVVGSGAPLVVSDARTDPRTRSGPVVTHLRAAGYAGMPLTDPHGTVLGALCAVDTRPRRWSEREVQALEDLAAACTAELRLRIVSRQAEEARAETAALLARSELVLRASEVLADTAGVEEVRTQVGELITSDLKPVYVGFSLEPAPRPGRARGPARAHPQAPQVDPDDGAWPTARAVRDKRLVEVHGVDEVRAAYGRHAAARWESLGFASMVCLPLAGTHRTLGALALAWDTEHRPDVAERAVLYAVSGYAAQALERAQFLDDRIDVARRLQEAMLTDLPAVDGLATAALYRPAAAQDMVGGDWYDAYPLDRAPCPGGETATLAVTIGDITGHDMRAATLMGQARSMLRQADHDHPDGGPATAVQALESANTALGLDLSGTLVHAHLAPAADGWTLTWTNAGHPAPLLARPGTSCEHLDDHDLLLHPSLHGRHRTQRRLHLPVGATLLLYTDGLVERPGQDIDTGIQRACALLHEGEDWPLEELLETIADRVAGDAPGDDIALLALRVTHPPHPDPA
>NC_021985.1|WP_162473327.1|8113913_8114057_+|hypothetical-protein
MRRFDLYARMRAGRDSLLRTQRSSPQDEDKAFQELEAVMARLREEQR
>NC_021985.1|WP_043477068.1|8114186_8114618_+|ATP-binding-protein
MLKTGAALVGDGTDIARARHLAAAFLTRVQAEHGLPVSQRAMDLTQLVVSELVTNARKYAPGPVLLDLAITGDTVEVAVWDACPVLPVARAADAGRVGQHGLEIVMAVARGFEARRESLGKRITVRIALADDPGGAVSGRRPL

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_021985_1	1.1|167007|21|NC_021985|CRISPRCasFinder	167007-167027	21	NC_021985.1	8105898-8105918	0	1.0
NC_021985_1	1.1|167007|21|NC_021985|CRISPRCasFinder	167007-167027	21	NC_021985.1	8105874-8105894	1	0.952
NC_021985_2	2.1|169932|60|NC_021985|CRISPRCasFinder	169932-169991	60	NC_021985.1	8102934-8102993	0	1.0
NC_021985_13	13.7|6649537|19|NC_021985|CRISPRCasFinder	6649537-6649555	19	NC_021985.1	3646752-3646770	2	0.895
NC_021985_13	13.7|6649537|19|NC_021985|CRISPRCasFinder	6649537-6649555	19	NC_021985.1	7896738-7896756	2	0.895
NC_021985_13	13.7|6649537|19|NC_021985|CRISPRCasFinder	6649537-6649555	19	NC_021985.1	376169-376187	2	0.895
NC_021985_19	19.1|8102901|60|NC_021985|CRISPRCasFinder	8102901-8102960	60	NC_021985.1	169965-170024	0	1.0

1. spacer 1.1|167007|21|NC_021985|CRISPRCasFinder matches to position: 8105898-8105918, mismatch: 0, identity: 1.0

ccggttctggctccggcgctt	CRISPR spacer
ccggttctggctccggcgctt	Protospacer
*********************

2. spacer 1.1|167007|21|NC_021985|CRISPRCasFinder matches to position: 8105874-8105894, mismatch: 1, identity: 0.952

ccggttctggctccggcgctt	CRISPR spacer
ccggttctggctcgggcgctt	Protospacer
************* *******

3. spacer 2.1|169932|60|NC_021985|CRISPRCasFinder matches to position: 8102934-8102993, mismatch: 0, identity: 1.0

gtgccgggcggggcgggggtgttgcccggcagcgcaccggcgggtgcggcgccggacggg	CRISPR spacer
gtgccgggcggggcgggggtgttgcccggcagcgcaccggcgggtgcggcgccggacggg	Protospacer
************************************************************

4. spacer 13.7|6649537|19|NC_021985|CRISPRCasFinder matches to position: 3646752-3646770, mismatch: 2, identity: 0.895

ggcccccccacgccccgcc	CRISPR spacer
ggcccccgcatgccccgcc	Protospacer
******* **.********

5. spacer 13.7|6649537|19|NC_021985|CRISPRCasFinder matches to position: 7896738-7896756, mismatch: 2, identity: 0.895

ggcccccccacgccccgcc	CRISPR spacer
ggaccgcccacgccccgcc	Protospacer
** ** *************

6. spacer 13.7|6649537|19|NC_021985|CRISPRCasFinder matches to position: 376169-376187, mismatch: 2, identity: 0.895

ggcccccccacgccccgcc	CRISPR spacer
ggaccgcccacgccccgcc	Protospacer
** ** *************

7. spacer 19.1|8102901|60|NC_021985|CRISPRCasFinder matches to position: 169965-170024, mismatch: 0, identity: 1.0

acccgccaccccgcccggcaccgcacccgccaccccgtccggcgccgcacccgccggtgc	CRISPR spacer
acccgccaccccgcccggcaccgcacccgccaccccgtccggcgccgcacccgccggtgc	Protospacer
************************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_021985_1	1.1|167007|21|NC_021985|CRISPRCasFinder	167007-167027	21	KT997871	Uncultured Mediterranean phage uvDeep-CGR2-AD7-C12, complete genome	1941-1961	1	0.952
NC_021985_3	3.2|965632|25|NC_021985|CRISPRCasFinder	965632-965656	25	NZ_CP034329	Tabrizicola piscis strain K13M18 plasmid unnamed1, complete sequence	19652-19676	3	0.88
NC_021985_3	3.2|965632|25|NC_021985|CRISPRCasFinder	965632-965656	25	NZ_CP021653	Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence	816678-816702	4	0.84
NC_021985_3	3.2|965632|25|NC_021985|CRISPRCasFinder	965632-965656	25	NZ_CP007797	Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence	40990-41014	4	0.84
NC_021985_3	3.2|965632|25|NC_021985|CRISPRCasFinder	965632-965656	25	NZ_CP021767	Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence	816676-816700	4	0.84
NC_021985_3	3.2|965632|25|NC_021985|CRISPRCasFinder	965632-965656	25	NZ_CP012688	Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence	816685-816709	4	0.84
NC_021985_3	3.2|965632|25|NC_021985|CRISPRCasFinder	965632-965656	25	CP047139	Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence	828141-828165	4	0.84
NC_021985_3	3.2|965632|25|NC_021985|CRISPRCasFinder	965632-965656	25	CP047137	Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence	791391-791415	4	0.84
NC_021985_3	3.2|965632|25|NC_021985|CRISPRCasFinder	965632-965656	25	MH509447	Microbacterium phage Eden, complete genome	29979-30003	4	0.84
NC_021985_10	10.1|5622134|26|NC_021985|CRISPRCasFinder	5622134-5622159	26	NZ_CP033036	Agrobacterium fabrum strain 12D13 plasmid pAt12D13a, complete sequence	271553-271578	4	0.846
NC_021985_10	10.1|5622134|26|NC_021985|CRISPRCasFinder	5622134-5622159	26	NZ_CP033024	Agrobacterium fabrum strain 1D132 plasmid pAt1D132a, complete sequence	202063-202088	4	0.846
NC_021985_15	15.1|7152868|27|NC_021985|CRT	7152868-7152894	27	NZ_LN831788	Streptomyces leeuwenhoekii strain type strain (C34 = DSM 42122 = NRRL B-24963) plasmid pSLE1, complete sequence	58927-58953	4	0.852
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	989366-989392	4	0.852
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	2355004-2355030	4	0.852
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NZ_CP030197	Salmonella enterica strain SA20051401 plasmid pSA20051401.1, complete sequence	41379-41405	4	0.852
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NZ_CP030198	Salmonella enterica strain SA20051401 plasmid pSA20051401.2, complete sequence	42407-42433	4	0.852
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NZ_AP014801	Rhodovulum sulfidophilum plasmid Plasmid1 DNA, complete genome, strain: DSM 2351	93155-93181	4	0.852
NC_021985_10	10.1|5622134|26|NC_021985|CRISPRCasFinder	5622134-5622159	26	NZ_CP040763	Paracoccus sp. 2251 plasmid unnamed4, complete sequence	47847-47872	5	0.808
NC_021985_10	10.1|5622134|26|NC_021985|CRISPRCasFinder	5622134-5622159	26	NZ_CP045400	Halomonas sp. THAF12 plasmid pTHAF12_a, complete sequence	17936-17961	5	0.808
NC_021985_10	10.1|5622134|26|NC_021985|CRISPRCasFinder	5622134-5622159	26	NZ_CP045402	Halomonas sp. THAF12 plasmid pTHAF12_c, complete sequence	13620-13645	5	0.808
NC_021985_10	10.1|5622134|26|NC_021985|CRISPRCasFinder	5622134-5622159	26	NZ_CP046573	Rhodococcus sp. WAY2 plasmid pRWAY01, complete sequence	669367-669392	5	0.808
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP011518	Pandoraea oxalativorans strain DSM 23570 plasmid pPO70-1, complete sequence	259622-259649	5	0.821
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_LR594669	Variovorax sp. SRS16 plasmid 4	105773-105800	5	0.821
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP049317	Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence	55401-55428	5	0.821
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NC_016623	Azospirillum lipoferum 4B plasmid AZO_p3, complete sequence	564345-564372	5	0.821
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP049157	Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence	1590523-1590550	5	0.821
NC_021985_15	15.1|7152868|27|NC_021985|CRT	7152868-7152894	27	NZ_AP017656	Sphingobium cloacae strain JCM 10874 plasmid pSCLO_2, complete sequence	118688-118714	5	0.815
NC_021985_15	15.1|7152868|27|NC_021985|CRT	7152868-7152894	27	NZ_CP011450	Sphingomonas sanxanigenens DSM 19645 = NX02 plasmid pNXO2, complete sequence	277776-277802	5	0.815
NC_021985_15	15.1|7152868|27|NC_021985|CRT	7152868-7152894	27	NZ_CP018821	Sphingomonas koreensis strain ABOJV plasmid tig00000001, complete sequence	294450-294476	5	0.815
NC_021985_15	15.1|7152868|27|NC_021985|CRT	7152868-7152894	27	NZ_CP039967	Pseudorhodobacter sp. S12M18 plasmid unnamed3, complete sequence	14919-14945	5	0.815
NC_021985_15	15.1|7152868|27|NC_021985|CRT	7152868-7152894	27	NC_022044	Paracoccus aminophilus JCM 7686 plasmid pAMI6, complete sequence	40927-40953	5	0.815
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	989366-989392	5	0.815
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	2355004-2355030	5	0.815
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	483627-483653	5	0.815
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	CP006880	Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence	195317-195343	5	0.815
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP049034	Fluviibacterium aquatile strain SC52 plasmid pSC52_6, complete sequence	55745-55771	5	0.815
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	MK814752	Gordonia phage Lutum, complete genome	9127-9153	5	0.815
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	MK376961	Gordonia phage Asapag, complete genome	9127-9153	5	0.815
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NC_048141	Gordonia phage Kenna, complete genome	9127-9153	5	0.815
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	MH651176	Gordonia phage Horus, complete genome	9127-9153	5	0.815
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NC_047891	Gordonia phage BENtherdunthat, complete genome	9127-9153	5	0.815
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NZ_CP032325	Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence	446456-446482	5	0.815
NC_021985_15	15.6|7153093|27|NC_021985|CRT	7153093-7153119	27	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	172735-172761	5	0.815
NC_021985_17	17.1|7447650|31|NC_021985|CRISPRCasFinder	7447650-7447680	31	NZ_CP030127	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence	462643-462673	5	0.839
NC_021985_17	17.1|7447650|31|NC_021985|CRISPRCasFinder	7447650-7447680	31	NZ_CP030129	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed3, complete sequence	23712-23742	5	0.839
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_JX627580	Methylobacterium oryzae CBMB20 plasmid pMOC1, complete sequence	145674-145701	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	1016014-1016041	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP030772	Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence	954028-954055	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP030772	Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence	13836-13863	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	498617-498644	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP020899	Rhizobium phaseoli Brasil 5 strain Bra5 plasmid pRphaBra5c, complete sequence	53796-53823	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP013554	Rhizobium phaseoli strain N931 plasmid pRphaN931b, complete sequence	53881-53908	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP013529	Rhizobium phaseoli strain R723 plasmid pRphaR723b, complete sequence	53867-53894	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP013539	Rhizobium phaseoli strain R630 plasmid pRphaR630b, complete sequence	52123-52150	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP013565	Rhizobium phaseoli strain N831 plasmid pRphaN831b, complete sequence	53881-53908	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP034352	Streptomyces sp. W1SF4 plasmid p2, complete sequence	37644-37671	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP013582	Rhizobium phaseoli strain N261 plasmid pRphaN261b, complete sequence	53867-53894	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NC_016586	Azospirillum lipoferum 4B plasmid AZO_p2, complete sequence	242295-242322	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	MT553342	Microbacterium phage Kelcole, complete genome	60978-61005	6	0.786
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NC_048068	Microbacterium phage OneinaGillian, complete genome	59869-59896	6	0.786
NC_021985_14	14.3|6732905|30|NC_021985|CRT	6732905-6732934	30	MN586014	Gordonia phage Keelan, complete genome	29335-29364	6	0.8
NC_021985_14	14.6|6733091|37|NC_021985|CRT	6733091-6733127	37	NZ_CP026091	Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence	695690-695726	6	0.838
NC_021985_14	14.6|6733091|37|NC_021985|CRT	6733091-6733127	37	NZ_CP012940	Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence	1492744-1492780	6	0.838
NC_021985_14	14.6|6733091|37|NC_021985|CRT	6733091-6733127	37	NZ_CP012944	Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence	351425-351461	6	0.838
NC_021985_14	14.6|6733091|37|NC_021985|CRT	6733091-6733127	37	NC_017575	Ralstonia solanacearum Po82 megaplasmid, complete sequence	695541-695577	6	0.838
NC_021985_14	14.6|6733091|37|NC_021985|CRT	6733091-6733127	37	NZ_CP026308	Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence	695519-695555	6	0.838
NC_021985_14	14.6|6733091|37|NC_021985|CRT	6733091-6733127	37	NZ_CP051295	Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence	1478299-1478335	6	0.838
NC_021985_15	15.1|7152868|27|NC_021985|CRT	7152868-7152894	27	NZ_CP029643	Arthrobacter dokdonellae isolate rhizosphere plasmid pDCT5, complete sequence	64556-64582	6	0.778
NC_021985_15	15.2|7152913|27|NC_021985|CRT	7152913-7152939	27	NZ_CP053711	Acetobacteraceae bacterium strain PAMC 26569 plasmid unnamed4, complete sequence	151853-151879	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_KY401053	Salmonella enterica subsp. enterica serovar Enteritidis strain SE380 plasmid unnamed, complete sequence	103225-103251	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP033089	Salmonella enterica subsp. enterica serovar Enteritidis strain SEO plasmid unnamed, complete sequence	29803-29829	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP026054	Salmonella enterica strain FDAARGOS_70 plasmid unnamed2, complete sequence	29745-29771	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP040645	Salmonella enterica subsp. enterica serovar Enteritidis strain SAP18-0432 plasmid pCFSAN074386, complete sequence	37738-37764	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP018653	Salmonella enterica subsp. enterica serovar Enteritidis strain 81-1705 plasmid pSE81-1705-2, complete sequence	5474-5500	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP028152	Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968 plasmid pRM2968-1, complete sequence	5474-5500	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP033342	Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN076214 plasmid pCFSAN076214_2, complete sequence	18416-18442	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	HG970000	Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 PT4 plasmid pSEN complete sequence	5474-5500	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP017233	Salmonella enterica strain FORC_051 plasmid pFORC51, complete sequence	38529-38555	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP009767	Salmonella enterica subsp. enterica serovar Enteritidis strain FORC_007 plasmid pFORC7, complete sequence	42213-42239	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP015525	Salmonella enterica subsp. enterica serovar Enteritidis strain SJTUF10978 plasmid pSJTUF10978, complete sequence	1731-1757	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP022004	Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051873 plasmid pCFSAN051873, complete sequence	36804-36830	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP015527	Salmonella enterica subsp. enterica serovar Enteritidis strain SJTUF10984 plasmid pSJTUF10984, complete sequence	1731-1757	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP011395	Salmonella enterica subsp. enterica serovar Enteritidis str. 18569 plasmid pCFSAN000006, complete sequence	21218-21244	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP041972	Salmonella enterica subsp. enterica serovar Enteritidis strain NCCP 16206 plasmid unnamed, complete sequence	37036-37062	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	MN125607	Salmonella enterica subsp. enterica serovar Enteritidis strain 1.1-2C7 plasmid p1.1-2C7, complete sequence	58030-58056	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	MN125608	Salmonella enterica subsp. enterica serovar Enteritidis strain 1.05-1C8 plasmid p1.05-1C8, complete sequence	87559-87585	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	MN125609	Salmonella enterica subsp. enterica serovar Enteritidis strain 1.15-2E5 plasmid p1.15-2E5, complete sequence	92411-92437	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP011943	Salmonella enterica subsp. enterica serovar Enteritidis strain OLF-00D989 87-1 plasmid virulence, complete sequence	5474-5500	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP020824	Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN033541 plasmid pCFSAN033541, complete sequence	54738-54764	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP020826	Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN033543 plasmid pCFSAN033543, complete sequence	48637-48663	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP032850	Salmonella enterica subsp. enterica serovar Enteritidis strain NCM 61 plasmid pM0061, complete sequence	9240-9266	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	LN879484	Salmonella enterica subsp. enterica serovar Enteritidis plasmid pSEN-BT, strain D7795	50147-50173	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP018660	Salmonella enterica subsp. enterica serovar Enteritidis strain 93-0639 plasmid pSE93-0639, complete sequence	15363-15389	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP018641	Salmonella enterica subsp. enterica serovar Enteritidis strain 70-1605 plasmid pSE70-1605, complete sequence	5482-5508	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP026714	Salmonella enterica strain FORC_078 plasmid pFORC_078_2, complete sequence	23975-24001	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP030796	Salmonella enterica strain 2017K-0021 plasmid p2017K-0021, complete sequence	23434-23460	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	717399-717425	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP025557	Salmonella enterica subsp. enterica serovar Enteritidis strain PIR00532 plasmid p1PIR00532, complete sequence	32117-32143	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_KX807610	Salmonella enterica subsp. enterica serovar Enteritidis strain CNM4839/03 plasmid pUO-SeVR1, complete sequence	59433-59459	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_KT317612	Salmonella enterica subsp. enterica serovar Enteritidis strain EC20120002 plasmid pSE12-2, complete sequence	10659-10685	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP018663	Salmonella enterica subsp. enterica serovar Enteritidis strain 95-0621 plasmid pSE95-0621-2, complete sequence	23722-23748	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP023437	Salmonella enterica strain FORC_074 plasmid pFORC74_2, complete sequence	8842-8868	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP018639	Salmonella enterica subsp. enterica serovar Enteritidis strain 69-3861 plasmid pSE69-3861-2, complete sequence	5285-5311	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP025553	Salmonella enterica subsp. enterica serovar Enteritidis strain ATCC BAA-708 plasmid pPIR00558, complete sequence	29657-29683	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP026570	Salmonella enterica strain MFDS1004839 plasmid pSE1004839, complete sequence	41743-41769	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	KT317611	Salmonella enterica subsp. enterica serovar Enteritidis str. EC20090641 plasmid pSE9-641, complete sequence	10660-10686	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	KT317613	Salmonella enterica subsp. enterica serovar Enteritidis str. EC20120005 plasmid pSE12-5, complete sequence	10659-10685	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP012397	Salmonella enterica strain FORC_019 plasmid pFORC19, complete sequence	85869-85895	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP039340	Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence	1705323-1705349	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP007508	Salmonella enterica subsp. enterica serovar Enteritidis strain Durban plasmid, complete sequence	26202-26228	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP008927	Salmonella enterica subsp. enterica serovar Enteritidis strain SEJ plasmid unnamed, complete sequence	10659-10685	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP041178	Salmonella enterica subsp. enterica serovar Enteritidis strain SJTUF12367v2 plasmid p12367B, complete sequence	21871-21897	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP050708	Salmonella enterica subsp. enterica serovar Enteritidis strain SE124 plasmid pSE124-2, complete sequence	11501-11527	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP007529	Salmonella enterica subsp. enterica serovar Enteritidis str. CDC_2010K_0968 isolate CDC_2010K-0968 plasmid p00, complete sequence	9631-9657	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP013098	Salmonella enterica subsp. enterica serovar Enteritidis strain CMCC50041 plasmid pCMCC50041, complete sequence	27912-27938	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP050711	Salmonella enterica subsp. enterica serovar Enteritidis strain SE109 plasmid pSE109-2, complete sequence	11501-11527	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP050725	Salmonella enterica subsp. enterica serovar Enteritidis strain SE74 plasmid pSE74-2, complete sequence	11501-11527	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NC_019120	Salmonella enterica subsp. enterica serovar Enteritidis plasmid pSENV, complete sequence	26198-26224	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP018636	Salmonella enterica subsp. enterica serovar Enteritidis strain 56-3991 plasmid pSE56-3991, complete sequence	10659-10685	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP018650	Salmonella enterica subsp. enterica serovar Enteritidis strain 81-1607 plasmid pSE81-1607-2, complete sequence	10659-10685	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP018656	Salmonella enterica subsp. enterica serovar Enteritidis strain 81-1706 plasmid pSE81-1706, complete sequence	82487-82513	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP050722	Salmonella enterica subsp. enterica serovar Enteritidis strain SE81 plasmid pSE81-1, complete sequence	11501-11527	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP050718	Salmonella enterica subsp. enterica serovar Enteritidis strain SE95 plasmid pSE95-2, complete sequence	11501-11527	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP040647	Salmonella enterica subsp. enterica serovar Enteritidis strain SAP18-H9654 plasmid pCFSAN074385, complete sequence	40504-40530	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP043434	Salmonella enterica subsp. enterica serovar Enteritidis strain PT1 plasmid pPT1-1, complete sequence	11501-11527	6	0.778
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP017178	Salmonella enterica strain FORC_056 plasmid unnamed1, complete sequence	28016-28042	6	0.778
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NC_009339	Mycolicibacterium gilvum PYR-GCK plasmid pMFLV01, complete sequence	125536-125562	6	0.778
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	483627-483653	6	0.778
NC_021985_17	17.1|7447650|31|NC_021985|CRISPRCasFinder	7447650-7447680	31	NZ_CP048307	Escherichia coli strain 9 plasmid p009_C, complete sequence	57408-57438	6	0.806
NC_021985_4	4.1|975975|32|NC_021985|CRISPRCasFinder	975975-976006	32	NC_016040	Sulfobacillus thermotolerans strain Y0017 plasmid pY0017, complete sequence	14027-14058	7	0.781
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_LR134466	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 24, complete sequence	47512-47539	7	0.75
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	1354212-1354239	7	0.75
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP020951	Rhizobium sp. CIAT894 plasmid pRheCIAT894d, complete sequence	66941-66968	7	0.75
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP029452	Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence	761809-761836	7	0.75
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	NZ_CP023071	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666b, complete sequence	721719-721746	7	0.75
NC_021985_13	13.2|6649321|28|NC_021985|CRISPRCasFinder	6649321-6649348	28	MT310894	Microbacterium phage Tempo, complete genome	61035-61062	7	0.75
NC_021985_14	14.1|6732809|30|NC_021985|CRT	6732809-6732838	30	NZ_CP027301	Serratia marcescens strain SGAir0764 plasmid unnamed_1	10683-10712	7	0.767
NC_021985_14	14.1|6732809|30|NC_021985|CRT	6732809-6732838	30	NZ_CP026519	Deinococcus sp. NW-56 plasmid unnamed3, complete sequence	12095-12124	7	0.767
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP015867	Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence	269064-269090	7	0.741
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP015867	Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence	298282-298308	7	0.741
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	841811-841837	7	0.741
NC_021985_15	15.4|7153003|27|NC_021985|CRT	7153003-7153029	27	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	843536-843562	7	0.741
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	165199-165225	7	0.741
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	882026-882052	7	0.741
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NC_012849	Ralstonia pickettii 12D plasmid pRp12D02, complete sequence	128027-128053	7	0.741
NC_021985_15	15.5|7153048|27|NC_021985|CRT	7153048-7153074	27	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	717399-717425	7	0.741
NC_021985_17	17.1|7447650|31|NC_021985|CRISPRCasFinder	7447650-7447680	31	NZ_CP016620	Microvirga ossetica strain V5/3m plasmid unnamed4, complete sequence	371634-371664	7	0.774
NC_021985_17	17.1|7447650|31|NC_021985|CRISPRCasFinder	7447650-7447680	31	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	297807-297837	8	0.742
NC_021985_17	17.1|7447650|31|NC_021985|CRISPRCasFinder	7447650-7447680	31	NZ_CP019083	Paludisphaera borealis strain PX4 plasmid PALBO1, complete sequence	92612-92642	8	0.742
NC_021985_18	18.1|7487574|37|NC_021985|CRISPRCasFinder	7487574-7487610	37	NZ_CP012399	Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence	390485-390521	9	0.757
NC_021985_18	18.1|7487574|37|NC_021985|CRISPRCasFinder	7487574-7487610	37	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	2483760-2483796	9	0.757

1. spacer 1.1|167007|21|NC_021985|CRISPRCasFinder matches to KT997871 (Uncultured Mediterranean phage uvDeep-CGR2-AD7-C12, complete genome) position: , mismatch: 1, identity: 0.952

ccggttctggctccggcgctt	CRISPR spacer
ccggttccggctccggcgctt	Protospacer
*******.*************

2. spacer 3.2|965632|25|NC_021985|CRISPRCasFinder matches to NZ_CP034329 (Tabrizicola piscis strain K13M18 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.88

ttcgttgccggagccctggccccgt	CRISPR spacer
ttcgttgccggagcccttgccgcgc	Protospacer
***************** *** **.

3. spacer 3.2|965632|25|NC_021985|CRISPRCasFinder matches to NZ_CP021653 (Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.84

ttcgttgccggagccctggccccgt	CRISPR spacer
ggcgttgccggagcccaggccgcgt	Protospacer
  ************** **** ***

4. spacer 3.2|965632|25|NC_021985|CRISPRCasFinder matches to NZ_CP007797 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence) position: , mismatch: 4, identity: 0.84

ttcgttgccggagccctggccccgt	CRISPR spacer
ttcgatgccggagccctggcctccg	Protospacer
**** ****************.*  

5. spacer 3.2|965632|25|NC_021985|CRISPRCasFinder matches to NZ_CP021767 (Ralstonia solanacearum strain RS 489 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.84

ttcgttgccggagccctggccccgt	CRISPR spacer
ggcgttgccggagcccaggccgcgt	Protospacer
  ************** **** ***

6. spacer 3.2|965632|25|NC_021985|CRISPRCasFinder matches to NZ_CP012688 (Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.84

ttcgttgccggagccctggccccgt	CRISPR spacer
ggcgttgccggagcccaggccgcgt	Protospacer
  ************** **** ***

7. spacer 3.2|965632|25|NC_021985|CRISPRCasFinder matches to CP047139 (Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.84

ttcgttgccggagccctggccccgt	CRISPR spacer
ggcgttgccggagcccaggccgcgt	Protospacer
  ************** **** ***

8. spacer 3.2|965632|25|NC_021985|CRISPRCasFinder matches to CP047137 (Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.84

ttcgttgccggagccctggccccgt	CRISPR spacer
ggcgttgccggagcccaggccgcgt	Protospacer
  ************** **** ***

9. spacer 3.2|965632|25|NC_021985|CRISPRCasFinder matches to MH509447 (Microbacterium phage Eden, complete genome) position: , mismatch: 4, identity: 0.84

ttcgttgccggagccctggccccgt	CRISPR spacer
ttcgttgccgtagccgtggccccac	Protospacer
********** **** *******..

10. spacer 10.1|5622134|26|NC_021985|CRISPRCasFinder matches to NZ_CP033036 (Agrobacterium fabrum strain 12D13 plasmid pAt12D13a, complete sequence) position: , mismatch: 4, identity: 0.846

cgtatggtggccagccgggcgcgccc	CRISPR spacer
ccaatggtggccagccggtcgcgccg	Protospacer
*  *************** ****** 

11. spacer 10.1|5622134|26|NC_021985|CRISPRCasFinder matches to NZ_CP033024 (Agrobacterium fabrum strain 1D132 plasmid pAt1D132a, complete sequence) position: , mismatch: 4, identity: 0.846

cgtatggtggccagccgggcgcgccc	CRISPR spacer
ccaatggtggccagccggtcgcgccg	Protospacer
*  *************** ****** 

12. spacer 15.1|7152868|27|NC_021985|CRT matches to NZ_LN831788 (Streptomyces leeuwenhoekii strain type strain (C34 = DSM 42122 = NRRL B-24963) plasmid pSLE1, complete sequence) position: , mismatch: 4, identity: 0.852

agcggccggcccgggaccggacaggga	CRISPR spacer
ggcggccggcccgggaccggacgaggt	Protospacer
.*********************..** 

13. spacer 15.5|7153048|27|NC_021985|CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 4, identity: 0.852

accggacagcccggcaccggacagccc	CRISPR spacer
tccggccagcccggcaccggccagcgc	Protospacer
 **** ************** **** *

14. spacer 15.5|7153048|27|NC_021985|CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 4, identity: 0.852

accggacagcccggcaccggacagccc	CRISPR spacer
tccggccagcccggcaccggccagcgc	Protospacer
 **** ************** **** *

15. spacer 15.5|7153048|27|NC_021985|CRT matches to NZ_CP030197 (Salmonella enterica strain SA20051401 plasmid pSA20051401.1, complete sequence) position: , mismatch: 4, identity: 0.852

accggacagcccggcaccggacagccc	CRISPR spacer
atctgacagcccggcaccggacggcgc	Protospacer
*.* ******************.** *

16. spacer 15.5|7153048|27|NC_021985|CRT matches to NZ_CP030198 (Salmonella enterica strain SA20051401 plasmid pSA20051401.2, complete sequence) position: , mismatch: 4, identity: 0.852

accggacagcccggcaccggacagccc	CRISPR spacer
atctgacagcccggcaccggacggcgc	Protospacer
*.* ******************.** *

17. spacer 15.5|7153048|27|NC_021985|CRT matches to NZ_AP014801 (Rhodovulum sulfidophilum plasmid Plasmid1 DNA, complete genome, strain: DSM 2351) position: , mismatch: 4, identity: 0.852

accggacagcccggcaccggacagccc	CRISPR spacer
agcgggcagcccggccccggacagctc	Protospacer
* ***.********* *********.*

18. spacer 10.1|5622134|26|NC_021985|CRISPRCasFinder matches to NZ_CP040763 (Paracoccus sp. 2251 plasmid unnamed4, complete sequence) position: , mismatch: 5, identity: 0.808

cgtatggtggccagccgggcgcgccc	CRISPR spacer
gacatggtggccagccgggcgcgggc	Protospacer
 ..********************  *

19. spacer 10.1|5622134|26|NC_021985|CRISPRCasFinder matches to NZ_CP045400 (Halomonas sp. THAF12 plasmid pTHAF12_a, complete sequence) position: , mismatch: 5, identity: 0.808

cgtatggtggccagccgggcgcgccc	CRISPR spacer
ccgatggcggccagccgggcgcgcag	Protospacer
*  ****.****************  

20. spacer 10.1|5622134|26|NC_021985|CRISPRCasFinder matches to NZ_CP045402 (Halomonas sp. THAF12 plasmid pTHAF12_c, complete sequence) position: , mismatch: 5, identity: 0.808

cgtatggtggccagccgggcgcgccc	CRISPR spacer
ccgatggcggccagccgggcgcgcag	Protospacer
*  ****.****************  

21. spacer 10.1|5622134|26|NC_021985|CRISPRCasFinder matches to NZ_CP046573 (Rhodococcus sp. WAY2 plasmid pRWAY01, complete sequence) position: , mismatch: 5, identity: 0.808

cgtatggtggccagccgggcgcgccc	CRISPR spacer
cggatggtggccagctgggcgcgggt	Protospacer
** ************.*******  .

22. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP011518 (Pandoraea oxalativorans strain DSM 23570 plasmid pPO70-1, complete sequence) position: , mismatch: 5, identity: 0.821

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
tgggccgccggcacggcccacctgcgcc	Protospacer
  *.***************.* ******

23. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_LR594669 (Variovorax sp. SRS16 plasmid 4) position: , mismatch: 5, identity: 0.821

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
gcgaccgccggcacggccagcaggcccg	Protospacer
.***************** *** ** * 

24. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP049317 (Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence) position: , mismatch: 5, identity: 0.821

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
tccagcgccgactcggcccgcatgcgcc	Protospacer
 * * *****.* ***************

25. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NC_016623 (Azospirillum lipoferum 4B plasmid AZO_p3, complete sequence) position: , mismatch: 5, identity: 0.821

acgac-cgccggcacggcccgcatgcgcc	CRISPR spacer
-cgctgcgccagcagggcccgcatgcgcc	Protospacer
 ** . ****.*** **************

26. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP049157 (Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence) position: , mismatch: 5, identity: 0.821

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
tccagcgccgactcggcccgcatgcgcc	Protospacer
 * * *****.* ***************

27. spacer 15.1|7152868|27|NC_021985|CRT matches to NZ_AP017656 (Sphingobium cloacae strain JCM 10874 plasmid pSCLO_2, complete sequence) position: , mismatch: 5, identity: 0.815

agcggccggcccgggaccggacaggga	CRISPR spacer
agcggccggcccgggaccggccccgag	Protospacer
******************** *  *..

28. spacer 15.1|7152868|27|NC_021985|CRT matches to NZ_CP011450 (Sphingomonas sanxanigenens DSM 19645 = NX02 plasmid pNXO2, complete sequence) position: , mismatch: 5, identity: 0.815

agcggccggcccgggaccggacaggga	CRISPR spacer
agcggccggcccgggaccggccccgag	Protospacer
******************** *  *..

29. spacer 15.1|7152868|27|NC_021985|CRT matches to NZ_CP018821 (Sphingomonas koreensis strain ABOJV plasmid tig00000001, complete sequence) position: , mismatch: 5, identity: 0.815

agcggccggcccgggaccggacaggga	CRISPR spacer
agcggccggcccgggaccggccccgag	Protospacer
******************** *  *..

30. spacer 15.1|7152868|27|NC_021985|CRT matches to NZ_CP039967 (Pseudorhodobacter sp. S12M18 plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.815

agcggccggcccgggaccggacaggga	CRISPR spacer
agcgcccggcccgggaccgcacagttt	Protospacer
**** ************** ****   

31. spacer 15.1|7152868|27|NC_021985|CRT matches to NC_022044 (Paracoccus aminophilus JCM 7686 plasmid pAMI6, complete sequence) position: , mismatch: 5, identity: 0.815

agcggccggcccgggaccggacaggga	CRISPR spacer
atggcccggtccgggaccggacagggc	Protospacer
*  * ****.**************** 

32. spacer 15.4|7153003|27|NC_021985|CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 5, identity: 0.815

cttggccagcccggcaccggacagccc	CRISPR spacer
tccggccagcccggcaccggccagcgc	Protospacer
...***************** **** *

33. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 5, identity: 0.815

cttggccagcccggcaccggacagccc	CRISPR spacer
tccggccagcccggcaccggccagcgc	Protospacer
...***************** **** *

34. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 5, identity: 0.815

cttggccagcccggcaccggacagccc	CRISPR spacer
ctccagcagcccggcaccggacacccc	Protospacer
**. . ***************** ***

35. spacer 15.4|7153003|27|NC_021985|CRT matches to CP006880 (Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence) position: , mismatch: 5, identity: 0.815

cttggccagcccggcaccggacagccc	CRISPR spacer
tttggccggcccggcatcggacagatc	Protospacer
.******.********.******* .*

36. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP049034 (Fluviibacterium aquatile strain SC52 plasmid pSC52_6, complete sequence) position: , mismatch: 5, identity: 0.815

cttggccagcccggcaccggacagccc	CRISPR spacer
catcgccagcccggccccggacagcag	Protospacer
* * *********** *********  

37. spacer 15.5|7153048|27|NC_021985|CRT matches to MK814752 (Gordonia phage Lutum, complete genome) position: , mismatch: 5, identity: 0.815

accggacagcccggcaccggacagccc	CRISPR spacer
cccggacaccgcggcaccggacagcgg	Protospacer
 ******* * **************  

38. spacer 15.5|7153048|27|NC_021985|CRT matches to MK376961 (Gordonia phage Asapag, complete genome) position: , mismatch: 5, identity: 0.815

accggacagcccggcaccggacagccc	CRISPR spacer
cccggacaccgcggcaccggacagcgg	Protospacer
 ******* * **************  

39. spacer 15.5|7153048|27|NC_021985|CRT matches to NC_048141 (Gordonia phage Kenna, complete genome) position: , mismatch: 5, identity: 0.815

accggacagcccggcaccggacagccc	CRISPR spacer
cccggacaccgcggcaccggacagcgg	Protospacer
 ******* * **************  

40. spacer 15.5|7153048|27|NC_021985|CRT matches to MH651176 (Gordonia phage Horus, complete genome) position: , mismatch: 5, identity: 0.815

accggacagcccggcaccggacagccc	CRISPR spacer
cccggacaccgcggcaccggacagcgg	Protospacer
 ******* * **************  

41. spacer 15.5|7153048|27|NC_021985|CRT matches to NC_047891 (Gordonia phage BENtherdunthat, complete genome) position: , mismatch: 5, identity: 0.815

accggacagcccggcaccggacagccc	CRISPR spacer
cccggacaccgcggcaccggacagcgg	Protospacer
 ******* * **************  

42. spacer 15.5|7153048|27|NC_021985|CRT matches to NZ_CP032325 (Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence) position: , mismatch: 5, identity: 0.815

accggacagcccggcaccggacagccc	CRISPR spacer
cgccgacagcccggcaccggccagcgc	Protospacer
  * **************** **** *

43. spacer 15.6|7153093|27|NC_021985|CRT matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 5, identity: 0.815

accggacagtccgggaccggccaggca	CRISPR spacer
gtcgggcagtccggcaccggccaggcc	Protospacer
..***.******** *********** 

44. spacer 17.1|7447650|31|NC_021985|CRISPRCasFinder matches to NZ_CP030127 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.839

-ccgcggtcagcccaggcgcttcagcagctcc	CRISPR spacer
gacctggtc-gcccaggcgcttcagcacctcc	Protospacer
  * .**** ***************** ****

45. spacer 17.1|7447650|31|NC_021985|CRISPRCasFinder matches to NZ_CP030129 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.839

-ccgcggtcagcccaggcgcttcagcagctcc	CRISPR spacer
gacctggtc-gcccaggcgcttcagcacctcc	Protospacer
  * .**** ***************** ****

46. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_JX627580 (Methylobacterium oryzae CBMB20 plasmid pMOC1, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
tcgaccgccggcacggccgtcatgcctg	Protospacer
 *****************  ***** . 

47. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
atccgcgcgggcacggcccgcatgcgcg	Protospacer
*.   *** ****************** 

48. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP030772 (Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
aacctctccgacacggcccgcatgcgcc	Protospacer
*   .* ***.*****************

49. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP030772 (Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
aacctctccgacacggcccgcatgcgcc	Protospacer
*   .* ***.*****************

50. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
tccgccgccggctcggcccgcgtgcgca	Protospacer
 * .******** ********.***** 

51. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP020899 (Rhizobium phaseoli Brasil 5 strain Bra5 plasmid pRphaBra5c, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
ggcaccgccggcacggccggcatgatcc	Protospacer
.  *************** *****  **

52. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP013554 (Rhizobium phaseoli strain N931 plasmid pRphaN931b, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
ggcaccgccggcacggccggcatgatcc	Protospacer
.  *************** *****  **

53. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP013529 (Rhizobium phaseoli strain R723 plasmid pRphaR723b, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
ggcaccgccggcacggccggcatgatcc	Protospacer
.  *************** *****  **

54. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP013539 (Rhizobium phaseoli strain R630 plasmid pRphaR630b, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
ggcaccgccggcacggccggcatgatcc	Protospacer
.  *************** *****  **

55. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP013565 (Rhizobium phaseoli strain N831 plasmid pRphaN831b, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
ggcaccgccggcacggccggcatgatcc	Protospacer
.  *************** *****  **

56. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP034352 (Streptomyces sp. W1SF4 plasmid p2, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
tccgacgccgtcaccgcccgcatgcgcc	Protospacer
 * . ***** *** *************

57. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP013582 (Rhizobium phaseoli strain N261 plasmid pRphaN261b, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
ggcaccgccggcacggccggcatgatcc	Protospacer
.  *************** *****  **

58. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NC_016586 (Azospirillum lipoferum 4B plasmid AZO_p2, complete sequence) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
acgaccgccggcccggcgcgcatcaggg	Protospacer
************ **** *****  *  

59. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to MT553342 (Microbacterium phage Kelcole, complete genome) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
ccatccgccggcactgccggcatgcgcg	Protospacer
 *. ********** *** ******** 

60. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NC_048068 (Microbacterium phage OneinaGillian, complete genome) position: , mismatch: 6, identity: 0.786

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
ccatccgccggcactgccggcatgcgcg	Protospacer
 *. ********** *** ******** 

61. spacer 14.3|6732905|30|NC_021985|CRT matches to MN586014 (Gordonia phage Keelan, complete genome) position: , mismatch: 6, identity: 0.8

atgcacggggcaccatcgcggggccatgca--	CRISPR spacer
atgtacggggcaccatcgcgga--cagtcagc	Protospacer
***.*****************.  **  **  

62. spacer 14.6|6733091|37|NC_021985|CRT matches to NZ_CP026091 (Ralstonia solanacearum strain IBSBF 2570 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.838

gggcatggccgtgcgccaggcatcgccgca-ccgccgt	CRISPR spacer
gctcaaggccgtgcgccaggcatcgtcgcagccgctg-	Protospacer
*  ** *******************.**** ****.* 

63. spacer 14.6|6733091|37|NC_021985|CRT matches to NZ_CP012940 (Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.838

gggcatggccgtgcgccaggcatcgccgca-ccgccgt	CRISPR spacer
gctcaaggccgtgcgccaggcatcgtcgcagccgctg-	Protospacer
*  ** *******************.**** ****.* 

64. spacer 14.6|6733091|37|NC_021985|CRT matches to NZ_CP012944 (Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.838

gggcatggccgtgcgccaggcatcgccgca-ccgccgt	CRISPR spacer
gctcaaggccgtgcgccaggcatcgtcgcagccgctg-	Protospacer
*  ** *******************.**** ****.* 

65. spacer 14.6|6733091|37|NC_021985|CRT matches to NC_017575 (Ralstonia solanacearum Po82 megaplasmid, complete sequence) position: , mismatch: 6, identity: 0.838

gggcatggccgtgcgccaggcatcgccgca-ccgccgt	CRISPR spacer
gctcaaggccgtgcgccaggcatcgtcgcagccgctg-	Protospacer
*  ** *******************.**** ****.* 

66. spacer 14.6|6733091|37|NC_021985|CRT matches to NZ_CP026308 (Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.838

gggcatggccgtgcgccaggcatcgccgca-ccgccgt	CRISPR spacer
gctcaaggccgtgcgccaggcatcgtcgcagccgctg-	Protospacer
*  ** *******************.**** ****.* 

67. spacer 14.6|6733091|37|NC_021985|CRT matches to NZ_CP051295 (Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence) position: , mismatch: 6, identity: 0.838

gggcatggccgtgcgccaggcatcgccgca-ccgccgt	CRISPR spacer
gctcaaggccgtgcgccaggcatcgtcgcagccgctg-	Protospacer
*  ** *******************.**** ****.* 

68. spacer 15.1|7152868|27|NC_021985|CRT matches to NZ_CP029643 (Arthrobacter dokdonellae isolate rhizosphere plasmid pDCT5, complete sequence) position: , mismatch: 6, identity: 0.778

agcggccggcccgggaccggacaggga	CRISPR spacer
gtcggccggcccggaaccggactggcc	Protospacer
. ************.******* **  

69. spacer 15.2|7152913|27|NC_021985|CRT matches to NZ_CP053711 (Acetobacteraceae bacterium strain PAMC 26569 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.778

ccgggacaggtcgacagcggtcggcca	CRISPR spacer
tgcggacaggtcgccagcggtcggctg	Protospacer
.  ********** ***********..

70. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_KY401053 (Salmonella enterica subsp. enterica serovar Enteritidis strain SE380 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

71. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP033089 (Salmonella enterica subsp. enterica serovar Enteritidis strain SEO plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

72. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP026054 (Salmonella enterica strain FDAARGOS_70 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

73. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP040645 (Salmonella enterica subsp. enterica serovar Enteritidis strain SAP18-0432 plasmid pCFSAN074386, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

74. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP018653 (Salmonella enterica subsp. enterica serovar Enteritidis strain 81-1705 plasmid pSE81-1705-2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

75. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP028152 (Salmonella enterica subsp. enterica serovar Enteritidis str. RM2968 plasmid pRM2968-1, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

76. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP033342 (Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN076214 plasmid pCFSAN076214_2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

77. spacer 15.4|7153003|27|NC_021985|CRT matches to HG970000 (Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 PT4 plasmid pSEN complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

78. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP017233 (Salmonella enterica strain FORC_051 plasmid pFORC51, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

79. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP009767 (Salmonella enterica subsp. enterica serovar Enteritidis strain FORC_007 plasmid pFORC7, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

80. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP015525 (Salmonella enterica subsp. enterica serovar Enteritidis strain SJTUF10978 plasmid pSJTUF10978, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

81. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP022004 (Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051873 plasmid pCFSAN051873, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

82. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP015527 (Salmonella enterica subsp. enterica serovar Enteritidis strain SJTUF10984 plasmid pSJTUF10984, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

83. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP011395 (Salmonella enterica subsp. enterica serovar Enteritidis str. 18569 plasmid pCFSAN000006, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

84. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP041972 (Salmonella enterica subsp. enterica serovar Enteritidis strain NCCP 16206 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

85. spacer 15.4|7153003|27|NC_021985|CRT matches to MN125607 (Salmonella enterica subsp. enterica serovar Enteritidis strain 1.1-2C7 plasmid p1.1-2C7, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

86. spacer 15.4|7153003|27|NC_021985|CRT matches to MN125608 (Salmonella enterica subsp. enterica serovar Enteritidis strain 1.05-1C8 plasmid p1.05-1C8, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

87. spacer 15.4|7153003|27|NC_021985|CRT matches to MN125609 (Salmonella enterica subsp. enterica serovar Enteritidis strain 1.15-2E5 plasmid p1.15-2E5, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

88. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP011943 (Salmonella enterica subsp. enterica serovar Enteritidis strain OLF-00D989 87-1 plasmid virulence, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

89. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP020824 (Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN033541 plasmid pCFSAN033541, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

90. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP020826 (Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN033543 plasmid pCFSAN033543, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

91. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP032850 (Salmonella enterica subsp. enterica serovar Enteritidis strain NCM 61 plasmid pM0061, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

92. spacer 15.4|7153003|27|NC_021985|CRT matches to LN879484 (Salmonella enterica subsp. enterica serovar Enteritidis plasmid pSEN-BT, strain D7795) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

93. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP018660 (Salmonella enterica subsp. enterica serovar Enteritidis strain 93-0639 plasmid pSE93-0639, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

94. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP018641 (Salmonella enterica subsp. enterica serovar Enteritidis strain 70-1605 plasmid pSE70-1605, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

95. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP026714 (Salmonella enterica strain FORC_078 plasmid pFORC_078_2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

96. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP030796 (Salmonella enterica strain 2017K-0021 plasmid p2017K-0021, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

97. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
gatcagcagcccggcaccggacagcgc	Protospacer
  * . ******************* *

98. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP025557 (Salmonella enterica subsp. enterica serovar Enteritidis strain PIR00532 plasmid p1PIR00532, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

99. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_KX807610 (Salmonella enterica subsp. enterica serovar Enteritidis strain CNM4839/03 plasmid pUO-SeVR1, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

100. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_KT317612 (Salmonella enterica subsp. enterica serovar Enteritidis strain EC20120002 plasmid pSE12-2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

101. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP018663 (Salmonella enterica subsp. enterica serovar Enteritidis strain 95-0621 plasmid pSE95-0621-2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

102. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP023437 (Salmonella enterica strain FORC_074 plasmid pFORC74_2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

103. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP018639 (Salmonella enterica subsp. enterica serovar Enteritidis strain 69-3861 plasmid pSE69-3861-2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

104. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP025553 (Salmonella enterica subsp. enterica serovar Enteritidis strain ATCC BAA-708 plasmid pPIR00558, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

105. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP026570 (Salmonella enterica strain MFDS1004839 plasmid pSE1004839, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

106. spacer 15.4|7153003|27|NC_021985|CRT matches to KT317611 (Salmonella enterica subsp. enterica serovar Enteritidis str. EC20090641 plasmid pSE9-641, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

107. spacer 15.4|7153003|27|NC_021985|CRT matches to KT317613 (Salmonella enterica subsp. enterica serovar Enteritidis str. EC20120005 plasmid pSE12-5, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

108. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP012397 (Salmonella enterica strain FORC_019 plasmid pFORC19, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

109. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP039340 (Ralstonia solanacearum strain UW386 plasmid pUW386, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
accagccagcccggcaccggcccgccc	Protospacer
 ...**************** * ****

110. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP007508 (Salmonella enterica subsp. enterica serovar Enteritidis strain Durban plasmid, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

111. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP008927 (Salmonella enterica subsp. enterica serovar Enteritidis strain SEJ plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

112. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP041178 (Salmonella enterica subsp. enterica serovar Enteritidis strain SJTUF12367v2 plasmid p12367B, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

113. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP050708 (Salmonella enterica subsp. enterica serovar Enteritidis strain SE124 plasmid pSE124-2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

114. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP007529 (Salmonella enterica subsp. enterica serovar Enteritidis str. CDC_2010K_0968 isolate CDC_2010K-0968 plasmid p00, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

115. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP013098 (Salmonella enterica subsp. enterica serovar Enteritidis strain CMCC50041 plasmid pCMCC50041, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

116. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP050711 (Salmonella enterica subsp. enterica serovar Enteritidis strain SE109 plasmid pSE109-2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

117. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP050725 (Salmonella enterica subsp. enterica serovar Enteritidis strain SE74 plasmid pSE74-2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

118. spacer 15.4|7153003|27|NC_021985|CRT matches to NC_019120 (Salmonella enterica subsp. enterica serovar Enteritidis plasmid pSENV, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

119. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP018636 (Salmonella enterica subsp. enterica serovar Enteritidis strain 56-3991 plasmid pSE56-3991, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

120. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP018650 (Salmonella enterica subsp. enterica serovar Enteritidis strain 81-1607 plasmid pSE81-1607-2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

121. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP018656 (Salmonella enterica subsp. enterica serovar Enteritidis strain 81-1706 plasmid pSE81-1706, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

122. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP050722 (Salmonella enterica subsp. enterica serovar Enteritidis strain SE81 plasmid pSE81-1, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

123. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP050718 (Salmonella enterica subsp. enterica serovar Enteritidis strain SE95 plasmid pSE95-2, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

124. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP040647 (Salmonella enterica subsp. enterica serovar Enteritidis strain SAP18-H9654 plasmid pCFSAN074385, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

125. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP043434 (Salmonella enterica subsp. enterica serovar Enteritidis strain PT1 plasmid pPT1-1, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

126. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP017178 (Salmonella enterica strain FORC_056 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

cttggccagcccggcaccggacagccc	CRISPR spacer
ggtagccagcccggcagcggacagcag	Protospacer
  *.************ ********  

127. spacer 15.5|7153048|27|NC_021985|CRT matches to NC_009339 (Mycolicibacterium gilvum PYR-GCK plasmid pMFLV01, complete sequence) position: , mismatch: 6, identity: 0.778

accggacagcccggcaccggacagccc	CRISPR spacer
cccggacagcccggcaccgggtaccga	Protospacer
 *******************..* *  

128. spacer 15.5|7153048|27|NC_021985|CRT matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 6, identity: 0.778

accggacagcccggcaccggacagccc	CRISPR spacer
ctccagcagcccggcaccggacacccc	Protospacer
 .* ..***************** ***

129. spacer 17.1|7447650|31|NC_021985|CRISPRCasFinder matches to NZ_CP048307 (Escherichia coli strain 9 plasmid p009_C, complete sequence) position: , mismatch: 6, identity: 0.806

ccgcggtcagcccaggcgcttcagcagctcc	CRISPR spacer
cggcgcccagcccaggcgcttcagcaccgct	Protospacer
* *** .******************* * *.

130. spacer 4.1|975975|32|NC_021985|CRISPRCasFinder matches to NC_016040 (Sulfobacillus thermotolerans strain Y0017 plasmid pY0017, complete sequence) position: , mismatch: 7, identity: 0.781

agggcccgaccaccacctctcccctccgacgc	CRISPR spacer
agggcccgaccaccgccgctcccccactgccc	Protospacer
**************.** ******. * .* *

131. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_LR134466 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 24, complete sequence) position: , mismatch: 7, identity: 0.75

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
ggcaccgccggtacggcccgcaggcgat	Protospacer
.  ********.********** *** .

132. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 7, identity: 0.75

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
acgaccgccggcacggccagcccggtat	Protospacer
****************** ** .*   .

133. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP020951 (Rhizobium sp. CIAT894 plasmid pRheCIAT894d, complete sequence) position: , mismatch: 7, identity: 0.75

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
ggcaccgccggcacggccggcatgatca	Protospacer
.  *************** *****  * 

134. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP029452 (Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence) position: , mismatch: 7, identity: 0.75

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
acgaccgccggcacggccagcccggtat	Protospacer
****************** ** .*   .

135. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to NZ_CP023071 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666b, complete sequence) position: , mismatch: 7, identity: 0.75

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
acgaccgccggcacggccagcccggtat	Protospacer
****************** ** .*   .

136. spacer 13.2|6649321|28|NC_021985|CRISPRCasFinder matches to MT310894 (Microbacterium phage Tempo, complete genome) position: , mismatch: 7, identity: 0.75

acgaccgccggcacggcccgcatgcgcc	CRISPR spacer
gaacccgccggcactgccggcatgcgcg	Protospacer
. . ********** *** ******** 

137. spacer 14.1|6732809|30|NC_021985|CRT matches to NZ_CP027301 (Serratia marcescens strain SGAir0764 plasmid unnamed_1) position: , mismatch: 7, identity: 0.767

---gtgcacggggcaccatcgcgcggccatgca	CRISPR spacer
ccgatgc---cggcaccagcgcgcggccatgct	Protospacer
   .***    ******* ************* 

138. spacer 14.1|6732809|30|NC_021985|CRT matches to NZ_CP026519 (Deinococcus sp. NW-56 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.767

gtgcacggggcaccatcgcgcggccatgca	CRISPR spacer
tcccgccgggcacgatctcgcggccatgca	Protospacer
 . *.* ****** *** ************

139. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP015867 (Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence) position: , mismatch: 7, identity: 0.741

cttggccagcccggcaccggacagccc	CRISPR spacer
gcgggccagcccggcaccggccagata	Protospacer
 . ***************** *** . 

140. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP015867 (Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence) position: , mismatch: 7, identity: 0.741

cttggccagcccggcaccggacagccc	CRISPR spacer
gcgggccagcccggcaccggccagata	Protospacer
 . ***************** *** . 

141. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 7, identity: 0.741

cttggccagcccggcaccggacagccc	CRISPR spacer
gcgttccggcccggcaccggacagcct	Protospacer
 .   **.******************.

142. spacer 15.4|7153003|27|NC_021985|CRT matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 7, identity: 0.741

cttggccagcccggcaccggacagccc	CRISPR spacer
gcgttccggcccggcaccggacagcct	Protospacer
 .   **.******************.

143. spacer 15.5|7153048|27|NC_021985|CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 7, identity: 0.741

accggacagcccggcaccggacagccc	CRISPR spacer
gccggacagcccggcaccggtgcgaga	Protospacer
.*******************   *   

144. spacer 15.5|7153048|27|NC_021985|CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 7, identity: 0.741

accggacagcccggcaccggacagccc	CRISPR spacer
gccggacagcccggcaccggtgcgaga	Protospacer
.*******************   *   

145. spacer 15.5|7153048|27|NC_021985|CRT matches to NC_012849 (Ralstonia pickettii 12D plasmid pRp12D02, complete sequence) position: , mismatch: 7, identity: 0.741

accggacagcccggcaccggacagccc	CRISPR spacer
gttacacagcccggcaccggccagcct	Protospacer
.... *************** *****.

146. spacer 15.5|7153048|27|NC_021985|CRT matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.741

accggacagcccggcaccggacagccc	CRISPR spacer
gatcagcagcccggcaccggacagcgc	Protospacer
. . ..******************* *

147. spacer 17.1|7447650|31|NC_021985|CRISPRCasFinder matches to NZ_CP016620 (Microvirga ossetica strain V5/3m plasmid unnamed4, complete sequence) position: , mismatch: 7, identity: 0.774

ccgcggtcagcccaggcgcttcagcagctcc	CRISPR spacer
acgggtgtagccgaggcgcttcatcagctcc	Protospacer
 ** *  .**** ********** *******

148. spacer 17.1|7447650|31|NC_021985|CRISPRCasFinder matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.742

ccgcggtcagcccaggcgcttcagcagctcc	CRISPR spacer
ggcgggtcagcccaggcgcatcagcaggtgg	Protospacer
    *************** ******* *  

149. spacer 17.1|7447650|31|NC_021985|CRISPRCasFinder matches to NZ_CP019083 (Paludisphaera borealis strain PX4 plasmid PALBO1, complete sequence) position: , mismatch: 8, identity: 0.742

ccgcggtcagcccaggcgcttcagcagctcc	CRISPR spacer
ctgttcccagaccaggcgctccagcagctcg	Protospacer
*.*.  .*** *********.********* 

150. spacer 18.1|7487574|37|NC_021985|CRISPRCasFinder matches to NZ_CP012399 (Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence) position: , mismatch: 9, identity: 0.757

cgcgtgagcgcacgggccgtggcgcaggtgcgcctcg	CRISPR spacer
cggctcgccgcacgggccgtcgcggaggtgcgccgcc	Protospacer
**  * . ************ *** ********* * 

151. spacer 18.1|7487574|37|NC_021985|CRISPRCasFinder matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.757

cgcgtgagcgcacgggccgtggcgcaggtgcgcctcg-	CRISPR spacer
tgcgtgagcgtatgggccgtggcgca-gtacacggagc	Protospacer
.*********.*.************* **.*.*   *