CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NC_022050	Paracoccus aminophilus JCM 7686 plasmid pAMI8, complete sequence	0 crisprs	PrimPol	0	1
NC_022042	Paracoccus aminophilus JCM 7686 plasmid pAMI1, complete sequence	0 crisprs	csa3	0	0
NC_022043	Paracoccus aminophilus JCM 7686 plasmid pAMI5, complete sequence	0 crisprs	csa3	0	0
NC_022041	Paracoccus aminophilus JCM 7686, complete sequence	3 crisprs	DEDDh,csa3,cas3,cas2	6	8
NC_022044	Paracoccus aminophilus JCM 7686 plasmid pAMI6, complete sequence	0 crisprs	NA	0	0
NC_022049	Paracoccus aminophilus JCM 7686 plasmid pAMI4, complete sequence	0 crisprs	csa3,DEDDh,cas3	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

77640 : 98953

Brevibacillus_phage(28.57%)

integrase

attL 69871:69885|attR 102260:102274

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
69871:69885	attL	NA	NA	NA	NA
WP_020952625.1\|77640_79176_+\|integrase	tyrosine-type recombinase/integrase	A0A0K2CP59	Brevibacillus_phage	1.8e-11	25.0
WP_020952627.1\|79172_80084_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_020952628.1\|80080_81094_+\|integrase	tyrosine-type recombinase/integrase	A0A2K9VH72	Gordonia_phage	9.9e-14	29.2
WP_148292726.1\|81161_83669_-	DEAD/DEAH box helicase family protein	A0A2K9R7J3	Dishui_lake_phycodnavirus	6.9e-32	29.6
WP_020952631.1\|86923_88129_+	chromate efflux transporter	NA	NA	NA	NA
WP_020952632.1\|88254_88578_-	DUF736 domain-containing protein	NA	NA	NA	NA
WP_020952635.1\|90665_91076_-	antirestriction protein	NA	NA	NA	NA
WP_020952636.1\|91241_91532_+	hypothetical protein	NA	NA	NA	NA
WP_020952637.1\|91565_92207_-	hypothetical protein	A0A2I6PI07	Pseudomonas_phage	1.2e-33	37.1
WP_020952638.1\|92206_92770_-	hypothetical protein	NA	NA	NA	NA
WP_020952639.1\|92899_93757_-	hypothetical protein	A0A1X9SH15	Bradyrhizobium_phage	5.6e-18	32.2
WP_041528424.1\|93753_94191_-	hypothetical protein	NA	NA	NA	NA
WP_020952642.1\|94845_95331_-	hypothetical protein	NA	NA	NA	NA
WP_020952643.1\|95750_96992_+\|integrase	tyrosine-type recombinase/integrase	A0A1B1IQT7	uncultured_Mediterranean_phage	2.4e-09	31.0
WP_020952644.1\|96981_97944_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_020952645.1\|97936_98953_+\|integrase	site-specific integrase	A0A0K2CP59	Brevibacillus_phage	5.7e-17	27.3
102260:102274	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_022041

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CRISPR-Cas detection and classification

Crispr_ID: NC_022041_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022041_1

2266224-2266306

Orphan

Consensus_repeat	Method
TGTCCACATTTTCTCCTTTAGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022041_1

>merge|NC_022041|1|2266224-2266306|CRISPRCasFinder
TGTCCACATTTTCTCCTTTAGAGGGCAAGCAACCACCAAAACCCTGAGGACAACCGCGGATGTCCACATTTTCTCCTTTAGAG

>NC_022041|1|1|2266224-2266306|CRISPRCasFinder
TGTCCACATTTTCTCCTTTAGAG	GGCAAGCAACCACCAAAACCCTGAGGACAACCGCGGA
TGTCCACATTTTCTCCTTTAGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022041.1\|WP_020950910.1\|2261577_2261979_+\|P27-family-phage-terminase-small-subunit	unknown	unknown	gnl\|CDD\|377461
NC_022041.1\|WP_084621064.1\|2269421_2270942_-\|DNA-recombination-protein-RmuC	unknown	unknown	gnl\|CDD\|376878
NC_022041.1\|WP_041527296.1\|2267879_2268101_+\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020950920.1\|2271661_2272516_-\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020950911.1\|2261975_2263628_+\|phage-terminase-large-subunit	unknown	unknown	gnl\|CDD\|226974
NC_022041.1\|WP_041527294.1\|2261269_2261581_+\|phage-head-closure-protein	unknown	unknown	gnl\|CDD\|377521
NC_022041.1\|WP_020950906.1\|2260088_2260397_+\|phage-gp6-like-head-tail-connector-protein	unknown	unknown	gnl\|CDD\|153446
NC_022041.1\|WP_020950922.1\|2274837_2276790_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NC_022041.1\|WP_020950921.1\|2272711_2274700_-\|RNA-polymerase-sigma-factor-RpoD	unknown	unknown	gnl\|CDD\|235549
NC_022041.1\|WP_020950903.1\|2257322_2258039_+\|tail-assembly-protein	unknown	unknown	gnl\|CDD\|227067
NC_022041.1\|WP_020950917.1\|2269127_2269400_+\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020950904.1\|2258225_2259323_+\|DUF262-domain-containing-protein	unknown	unknown	gnl\|CDD\|377008
NC_022041.1\|WP_020950907.1\|2260396_2260855_+\|HK97-gp10-family-phage-protein	unknown	unknown	gnl\|CDD\|377415
NC_022041.1\|WP_020950913.1\|2266636_2267062_+\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020950914.1\|2267119_2267722_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378733
NC_022041.1\|WP_020950908.1\|2260847_2261270_+\|DUF3168-domain-containing-protein	unknown	unknown	gnl\|CDD\|378648
NC_022041.1\|WP_148292610.1\|2259355_2259949_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376160
NC_022041.1\|WP_020950916.1\|2268589_2269054_+\|DUF2380-domain-containing-protein	unknown	unknown	gnl\|CDD\|371669
NC_022041.1\|WP_020950919.1\|2271097_2271646_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|377026
NC_022041.1\|WP_020950912.1\|2263646_2266190_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273681

Protein	Function_ID	Function_description	E-value
NC_022041.1\|WP_020950910.1\|2261577_2261979_+\|P27-family-phage-terminase-small-subunit	gnl\|CDD\|377461	pfam05119, Terminase_4, Phage terminase, small subunit.	1.54624e-14
NC_022041.1\|WP_084621064.1\|2269421_2270942_-\|DNA-recombination-protein-RmuC	gnl\|CDD\|376878	pfam02646, RmuC, RmuC family. This family contains several bacterial RmuC DNA recombination proteins. The function of the RMUC protein is unknown but it is suspected that it is either a structural protein that protects DNA against nuclease action, or is itself involved in DNA cleavage at the regions of DNA secondary structures.	1.09736e-109
NC_022041.1\|WP_020950911.1\|2261975_2263628_+\|phage-terminase-large-subunit	gnl\|CDD\|226974	COG4626, COG4626, Phage terminase-like protein, large subunit [General function prediction only].	4.05811e-63
NC_022041.1\|WP_020950906.1\|2260088_2260397_+\|phage-gp6-like-head-tail-connector-protein	gnl\|CDD\|153446	cd08054, gp6, Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins. The bacteriophage HK97 gp6 protein is critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. It forms a dodecameric ring structure that comprises the middle ring of the connector, located between the portal protein (attached to the head) and the gp7 ring (attached to the tail). It is a component of the mature phage and the absence of HK97 gp6 results in defective head-tail joining and the absence of mature phage particles. Although the crystal structure of HK97 gp6 shows an unexpected 13-mer ring, the biological form present in the mature phage is believed to be a dodecamer.	1.33021e-14
NC_022041.1\|WP_020950922.1\|2274837_2276790_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NC_022041.1\|WP_020950921.1\|2272711_2274700_-\|RNA-polymerase-sigma-factor-RpoD	gnl\|CDD\|235549	PRK05658, PRK05658, RNA polymerase sigma factor RpoD; Validated.	0
NC_022041.1\|WP_020950903.1\|2257322_2258039_+\|tail-assembly-protein	gnl\|CDD\|227067	COG4723, COG4723, Phage-related protein, tail component [Function unknown].	2.22707e-21
NC_022041.1\|WP_020950904.1\|2258225_2259323_+\|DUF262-domain-containing-protein	gnl\|CDD\|377008	pfam03235, DUF262, Protein of unknown function DUF262.	2.33778e-30
NC_022041.1\|WP_020950907.1\|2260396_2260855_+\|HK97-gp10-family-phage-protein	gnl\|CDD\|377415	pfam04883, HK97-gp10_like, Bacteriophage HK97-gp10, putative tail-component. This family of proteins is found in the caudovirales. It may be a tail component.	1.6871e-06
NC_022041.1\|WP_041527294.1\|2261269_2261581_+\|phage-head-closure-protein	gnl\|CDD\|377521	pfam05521, Phage_H_T_join, Phage head-tail joining protein.	4.45927e-13
NC_022041.1\|WP_020950914.1\|2267119_2267722_+\|hypothetical-protein	gnl\|CDD\|378733	pfam11844, DUF3364, Domain of unknown function (DUF3364). This domain is functionally uncharacterized. This domain is found in bacteria. This presumed domain is about 60 amino acids in length.	0.000471604
NC_022041.1\|WP_020950908.1\|2260847_2261270_+\|DUF3168-domain-containing-protein	gnl\|CDD\|378648	pfam11367, DUF3168, Protein of unknown function (DUF3168). This family of proteins has no known function but is likely to be a component of bacteriophage.	5.73949e-06
NC_022041.1\|WP_148292610.1\|2259355_2259949_+\|hypothetical-protein	gnl\|CDD\|376160	pfam18737, HEPN_MAE_28990, MAE_28990/MAE_18760-like HEPN. HEPN-like nuclease. MAE_28990 In operon with a ParB nuclease and DNA methylase genes. MAE_18760-like HEPN found fused to HEPN/RES-NTD1, HEPN/Toprim-NTD1, Schlafen and a novel beta rich domain. In operon with ParA/Soj ATPase of SIMIBI-type GTPase fold.	5.20561e-09
NC_022041.1\|WP_020950916.1\|2268589_2269054_+\|DUF2380-domain-containing-protein	gnl\|CDD\|371669	pfam11684, DUF3280, Protein of unknown function (DUF2380). This family of proteins with unknown function appears to be restricted to Proteobacteria.	2.7639e-23
NC_022041.1\|WP_020950919.1\|2271097_2271646_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|377026	pfam03358, FMN_red, NADPH-dependent FMN reductase.	3.34896e-35
NC_022041.1\|WP_020950912.1\|2263646_2266190_+\|hypothetical-protein	gnl\|CDD\|273681	TIGR01541, tail_length_tape, phage tail tape measure protein, lambda family. This model represents a relatively well-conserved region near the C-terminus of the tape measure protein of a lambda and related phage. This protein, which controls phage tail length, is typically about 1000 residues in length. Both low-complexity sequence and insertion/deletion events appear common in this family. Mutational studies suggest a ruler or template role in the determination of phage tail length. Similar behavior is attributed to proteins from distantly related or unrelated families in other phage. [Mobile and extrachromosomal element functions, Prophage functions].	1.8576e-07

>NC_022041.1|WP_020950912.1|2263646_2266190_+|hypothetical-protein
MALDETGLLIKLEANVSKWEKDFNRAISQQNRASQRMEQLAKRNAQKIAQQYEGLGPKIGKAFEGIPSALKGLGSAFLGGLAGGLAVGGITEFTRSLGEATRGIAEIKNEAARAGVTTTVFQEWKYLADENRISVDALADGFKELGMRADEFIVTGVGPAAEAFTRLGYSADQLKAKLKDPSALMLEVLGRASKFDKSAQNRILDETFGGTGAEQLAVLLGQGEDAMRATIERAHEVGAVLDSDVIDRAAEVDRKFTALQASVSNFGKRVVISVAEGVVALTDFRDHLDALFPNEAVGRQVLGDAFYDDLAQSEQAAQENAATLRGLTEQYNQLADSASSAAPALLDAAATLRLMGNDDAADALQAAADRMQALAGSFQDGTMTGEEFAAQLTEVKREADNTFASLSDVDRASFGTVIGELGVLGGAIAGVLSLAQSLSSAMASLADGKAVKALRDRNEAEAASMASLDAMTKANENFAQSEAERNAATTASMKLEEARADARKRAAAAGAVLTEAEITTAAEAALAGDAARAAADKAARGGGKPKGGGGAKAEKLDDYAREVASIKEKTTALETEASVLLAVAASGEKMAGAMDFAQTKASLLTAALSAGKSQTPELIAQVDALARAYVTAGQKAEQAGDQMKSVEDNTKQGAQAFTDLVMSATEGSEAFAGALRNLGMQILQNSLLKLILGFAGQGGPFGSAMGWLGSALTPPAGFAAGGYTGDGGKHQVAGLVHRGEFVLSKAATERIGVGNLERLHQRALQGYSRGGLVGAAKKAATPASDSLRGAVQHINVTGGPITVNASGGTPEQNGDLARQIAKETERGMRDLVRDELVRQRRSGGILR
>NC_022041.1|WP_020950911.1|2261975_2263628_+|phage-terminase-large-subunit
MSKSTYPHWIFDGSEIPDPFGYGEQAVQFLRSLSHPQSALPGNAFQLDEWQERIVRRIYGPRHPDGSRIVKDVWLEVPRGNRKTSLAAAFSLLHLLGPEAVPQGQAYFCASDRKQAEIGFLEAMGIIRADSNLAQAVRINNPQIGTKSAKSLIDGTKLETTTADGDSYQGRTPTFVMCDEVHVWKNRKLWDSMWQGRRKRGALFITTTTAGRGRHGFAYDRYSLFRDIALGKINNPTKLPIIFEPEEGDDWLDEKVWHKVNPGMRYGYPILDEMRDDAITAQHDPIEGYEFRQMALNEWLGNSTSPLFNFDEYDAGAFTAEIGKDGKPVDYETDLEDCPCYLGVDYAQTGDLACIVAAWRHEGGVHDGKITIKPWFFVQSERLEDRERLEQVPYRQWVKDGQLIVVPGPMVTQQAVAEVVREISARHDVRRVGYDPYGFRAMATELLSEGIHMVEMKQSIAIMGPANGELIRAVNGRLIRHTNHPILRHHFDGVAAVVNDTGVVWMSKADKKRGHIDGAVAASMAVSGAVTDKDQGSYYSRDDVLGLLVA
>NC_022041.1|WP_020950910.1|2261577_2261979_+|P27-family-phage-terminase-small-subunit
MSVHHRGIKPAVSKDAEALTKAPPAPAYLSKWAKAEWRRIMPQLIARQIITRADLAGVENYCGAVGAACQIAEIINVMPVPDLKLGGLQIRYMQTARQLAAEYGLTPTSRARIGGGADQPDPNARPNPLSFRR
>NC_022041.1|WP_041527294.1|2261269_2261581_+|phage-head-closure-protein
MQAGKLQHRIELQRLTETLTASRKVQEVWTTYATGRAELRQAGLSEFLRNDVEGTTSNAVFLIRWIPGVSVADRITHDGKVWNIVAIAEIGRRRGLELRAVAA
>NC_022041.1|WP_020950908.1|2260847_2261270_+|DUF3168-domain-containing-protein
MLEPSLALQTAVGDALAASPAVTAHVAPERIRAGSIRPEFMPAILLPAGNVEILGRAASGQTVAEVSLILHLWAVQDSSDVAQEIAGAVLAVLMDAPPAAGFWFDEWDRPSLAWVPDPDPAQSHSHAAIKLRAVIRWRAI
>NC_022041.1|WP_020950907.1|2260396_2260855_+|HK97-gp10-family-phage-protein
MGEFVQGSEELQRKLMALRDKMPEAIRPTLMRAGEEVAKDARALAEASRRTGDLIESIHVTGPGETTPAHSTDGGARTAGPLEVLVTAGDTDARHAHLVEGGTVERQHKDGTSTGAMPAKPFFNPAWRLNRRKQEQRINRALRKAWREAVNA
>NC_022041.1|WP_020950906.1|2260088_2260397_+|phage-gp6-like-head-tail-connector-protein
MPLPTALVRAHLNILPGEREDEAEILTHYANVAEAWVSSYTGLPFDPANALMVQAALLLVSHSYESREAVTFASPYQLPYGVHDLLSGLKRHVISYTPDEAA
>NC_022041.1|WP_148292610.1|2259355_2259949_+|hypothetical-protein
MEIDRIRSWRKLELSQARAIAESRAGRAEEAYLCRSWAVMIYAHCDQAIKAVSRAYLDYLKVHPREGYDYRTAWLSFHGKEAIRHSSDARYLLCRPDVAEFRTDLIGGINQKAVIDTSNFSYPMLRFLSDWVVQCTFDHSLYRAFCSTLKEKRDAIAHGEEIFLRSVDDCISWHDPAISLLDGFSESALETALLHPA
>NC_022041.1|WP_020950904.1|2258225_2259323_+|DUF262-domain-containing-protein
MSKNSVNLEDVLDNARQTVKTDSYPMSIGELASMYEAGEIILRPEYQRYFRWSSEQKSKLIESILIGLPLPSVFVAQDEKGNWEVVDGMQRLSTIFDFMGIVDDETKRNAYYTAFETLSDDLYYIEEFTGKGWADFGRRIQLDFRRTKIQLTILLRETDLDAKFELFQRLNSGGTSISGQELRNAIIAGKNPEALKWFESLAQYEPFVKVCGMSDRDLSVRMDVELVLRFIVFLSDEIQSLPKAKSVDVFLTKALRNILSDDSFDYAGHEVTFKKTFDAILAAWGENALRYKSSPGTGKFSISFFEAVALGVAQNIEKLPSKKVLKEKIDSVGSNRAFRTASGSGKNAQRRIPELVKLGAKYFKI
>NC_022041.1|WP_020950903.1|2257322_2258039_+|tail-assembly-protein
MNDLYLHGALGKEFGRHFRFDIETIQDALMALRANFPTFANAIRNGFYEIVVGKTRTNGLSLEEAQLAGFRLGQNALHIVPVAAGRKRGGLGKIIAGIALIGLSAATAGGGGLLGGALWAGSNVTGSQIVGQIGTGMLLTGASSLIAPQQKAEDTTQSFTMSGPTSNLREGAIVPIAYGEVVTGGYMISGGISIERNSGDKNDDASAASSTSITIDTQGGSLRERVTTPGGASPTEDD
>NC_022041.1|WP_020950913.1|2266636_2267062_+|hypothetical-protein
MATTSGYIKIPASRLEQIKKVAEARGLSVADTLIHWIEREVEAGTISGDLPGVRVEVKAVNQVGITLDDIKLDPTRAEAVDFAKRLREIAAGHRLDIEERFAQVKRRGIGFLLTSTLTGKRFPMSSATAGAIANQIDRALA
>NC_022041.1|WP_020950914.1|2267119_2267722_+|hypothetical-protein
MHNQTTLIGGISQSQNTNSISESEPLAPFAGQSDTGILNWILRNGFTKLDKVSLGSYCHHLYKSKSGGGNFEPHVRAWFDALTAKQRDILKVRRNDPAKVAERQKKNAQRLEKQRADPEYQLSLANKRSNYRAKVEQEENRDVRDYTKLAGLTPEQKKERHKQQQYEAKKKKRALAKAASMTEAERQDAVMRADPNFGMF
>NC_022041.1|WP_041527296.1|2267879_2268101_+|hypothetical-protein
MKRNIYLLELEWDRLHRLLALRSLPIEDQNDRDAAEIALADAGWRLAQAGIMPVTLVADVEEVAVKMGLPVPH
>NC_022041.1|WP_020950916.1|2268589_2269054_+|DUF2380-domain-containing-protein
MRWLILLLALALPHPSRAEGIVVMPVKFLDTSKEATDQSAAHLDRIAILTQVLTEDIGATALSSQDIATACPKETPECLLAAAKAAGAQTAIFIVVHKSSSLIMQAFVQVLDVDQQHVLFKRDLNFRGDNDEAWRRAGIFMAHQFTKTPTTPAK
>NC_022041.1|WP_020950917.1|2269127_2269400_+|hypothetical-protein
MSFTVRLVISALVAVVVGCGMMYYDKKNGAEWVVSPDQLAAANGALESRPGTVTVRPIRSETADMLPFKWAGAGIAAGILAFVATRRKTA
>NC_022041.1|WP_084621064.1|2269421_2270942_-|DNA-recombination-protein-RmuC
MTISAWFSDPGRLQLLLAAGLFLALLCFSLWRRAVAGLRESAIRAELLQTQLSEQAAGAAAVAAQLAARAAEAEELRQARHQSELRLGRMESAHAGQGARLAELVEERDELRDALHAAQKLEAGLQRQLAETRLAADKDRESAERDIATLREVREEMSKNFKLMADETLRVQGEDMHKRQSENLTSLLTPFRDQVHRFQTELQTRNKQTDEERARLREQIEGLHKRSEEISREAVALTRALKGDRQKQGAWGEMILERLLEESGLEKGIHYLTQDTRQDEEGRRWRPDVVVRLPQKKVLVIDSKVSLSAYEEAVNAEDALVSAAAMKRHVAAIRAHITGLSDKGYQGLDQGAVDYVLMFIPIEGAFSEALRADPDLARFAMERRIGLTTPTTLMLTLRTVDHIWTVERRESNAMQIAARAGQLYDKLHGFVAAVEDVGTQLERAQKSHALAIDRLTRGPGNVIRQAEMLRELGARTQKRLGLDHDGLSAMQEDAPVSLPLEDQEEG
>NC_022041.1|WP_020950919.1|2271097_2271646_+|NAD(P)H-dependent-oxidoreductase
MTKSIAVLVGSLRKGAINLSLAHALEKLAEGKLKFHYVELGDLPLYNEDLWANPPAAVLRMKKEVSEADGILMLTPEYNRSYAGVLKNAMDWGSRPYGQSCWKNKPTAVTGASPGAIGAAVGQARLRNDLASLSTILMPGPEAYIQWKPEAYGADGSVTDENTRAFLQSFVDHFASFVEKLS
>NC_022041.1|WP_020950920.1|2271661_2272516_-|hypothetical-protein
MSIKSILLGAVAISTALSGVMLPVLSASAEEGHRRPAAEQSRGEARPVMRAEAMRRETTESPRQERVEVRRAADARQDHTERAPTHPGKGHSTGPVPQPTHVKAPTHPRKPGETVIVDRTVIDEGFGPFWPVGPAVVLEDAAIASVFGWQPTETVVETVPLADFGECHYHVVTDRVTGAEKVGVWIDGKEVIAGSKHAIEQVLTNCTAESTPASTFAQVVDGFYPELGGYNLVTTGPGIYAPEIIRENNIERVTYFARDKANETVKVHASWGPKQAVQVKTEKI
>NC_022041.1|WP_020950921.1|2272711_2274700_-|RNA-polymerase-sigma-factor-RpoD
MASKDDDDNKPDTKDDEHSLDMSQTAVKRMIAEGRERGFITYDQLNAVLPPDQVSSDQIEDVMSMLSEMDIRVVESDEDSDDSETGGQLATTGSGSREVALATTETEKLDRTDDPVRMYLREMGSVELLSREGEIAIAKRIEAGRNTMIAGLCESPLTFKAITMWREELLDEDILLRDVIDLEATFGRVLDEEGEDTELETAEPVVGAAPAQARTGDEEFDADGNPMRREDEEDDEDGQSLSLAAMEASLKPKVLETLEQIAHGYEELAHMQDSRMSATLNEDSTFSASDELAYQRKRSEIVLLVNELHLHNNRIEALVDQIYGINRRILTIDSGMVKLADAARINRQEFIKAYRGCELDPTWVDRMSSGTSRGWQTLFDKSRDQVDRLRGDMADVGQYVGVDIEEFRRIVNQVQRGEKEARQAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLVRTGRQMLHEIGREPTPEELAEKLQMPLEKVRKVMKIAKEPISLETPIGDEEDSQLGDFIEDKNAVLPLESAIQENLKETTTRVLASLTPREERVLRMRFGIGMNTDHTLEEVGQQFSVTRERIRQIEAKALRKLKHPSRSRKLRSFLDQ
>NC_022041.1|WP_020950922.1|2274837_2276790_-|DNA-primase
MSLSPQFLDEIRARVPLSRIIGRKVQWDLRRSNQAKGDWWAPCPFHQEKSASFHVDDQKGFYYCFGCHAKGDALRFMQEADGMGFLEAVEVLAGEAGLPMPARDPGQVQKTDRRAKLVEVMEEAVRWFRLQLQTGMAQEARDYLTRRGLSDPDRERFGIGYAPDQRQGLFQALKAKGIDERLIVEAGLCAKPDDGGAPFDRFRGRIMFPIRDARGRCIAFGGRAMDPNARAKYLNSPETPLFDKGRNLYNLGPARSAVGKGQPLIVAEGYMDVIALVKAGFEGAVAPLGTAITPEQLQLMWRVSPEPVIALDGDTAGVRAALRLIDLSLPMTGPGQALRFAILPEGQDPDDLIRKLGAPAMAEQLEAARPLVDLLWQRETEGKVFDSPERRAALDRSLGESVAKIPDPTTRDYYNAIFKQMKWELFSPRRSGDGASGRQPREFRENKGRGQGRGQGQGRSFDAPSVAATRASRLSSPEAAEKVAEQMIESMVLAICATHPKLVPTVEARLERLTPEDPGRAQLVHDLLAGTQSNSGRQALESILAEAHVKAAPLITRPQDGDSAADVLANALDRIEARRAARLETARAETEIEGLADEGLTWRVSQSARLRQKADHPAMSDLGDLGENSDAQRAFLKSALENEIWRKPRR

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Crispr_ID: NC_022041_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022041_2

2473801-2474133

Unclear

I-E:NA

Consensus_repeat	Method
CGGTTCATCCCCGCGGGTGCGGGGAACAG	PILER-CR
CGGTTCATCCCCGCGGGTGCGGGGAAC	CRISPRCasFinder
CGGTTCATCCCCGCGGGT	CRT
CGGTTCATCCCCGCGGGTGCGGGGAAC	CRISPRCasFinder

5 spacers

cas2

The CRISPR arrays of NC_022041_2

>merge|NC_022041|2|2473801-2474133|PILER-CR,CRISPRCasFinder,CRT,CRISPRCasFinder
CGGTTCATCCCCGCGGGTGCGGGGAACCGTAGCCCGGACCCCACTGCACGATCCGCCCGTCCGGTTCATCCCCGCGGGTACGGGGAACAGGCCGCCTTTTTCAGCGCCCGGCGCATCACCGCCGGTTCATCCCCGCGGGTGCCGGGAACAGCTGGCCGCGTCTTTCAAGATCCGTTCGGTGCGCAGTTCATCCCCCGGGTGCGGGGAACAGCAGCGAGTGCGCAGATTTGTTGAAATAAGGGGCGGTTCATCCCCGCCGGTGCGGGGAACAGAGTGCGGTCATGGTGACGGCCGAGCGGTTTATCGGTTCATCCCCGCGGGTGCGGGGAACAG

>NC_022041|2|1|2473801-2474133|PILER-CR
CGGTTCATCCCCGCGGGTGCGGGGAACCG	TAGCCCGGACCCCACTGCACGATCCGCCCGTC
CGGTTCATCCCCGCGGGTACGGGGAACAG	GCCGCCTTTTTCAGCGCCCGGCGCATCACCGC
CGGTTCATCCCCGCGGGTGCCGGGAACAG	CTGGCCGCGTCTTTCAAGATCCGTTCGGTGCG
CAGTTCATCCCCCGGGTGCGGGGAACAGC	AGCGAGTGCGCAGATTTGTTGAAATAAGGGGC
GGTTCATCCCCGCCGGTGCGGGGAACAGA	GTGCGGTCATGGTGACGGCCGAGCGGTTTATC
GGTTCATCCCCGCGGGTGCGGGGAACAG

>NC_022041|2|2|2473801-2473950|CRISPRCasFinder
CGGTTCATCCCCGCGGGTGCGGGGAAC	CGTAGCCCGGACCCCACTGCACGATCCGCCCGTC
CGGTTCATCCCCGCGGGTACGGGGAAC	AGGCCGCCTTTTTCAGCGCCCGGCGCATCACCGC
CGGTTCATCCCCGCGGGTGCCGGGAACAGCTGGCCGCGTCTTTCAAGATCCGTTCGGTGCGCAGTTCATCCCCCGGGTGCGGGGAACAGCAGCGAGTGCGCAGATTTGTTGAAATAAGGGGCGGTTCATCCCCGCCGGTGCGGGGAAC	AGAGTGCGGTCATGGTGACGGCCGAGCGGTTTAT


>NC_022041|2|1|2473801-2474122|CRT
CGGTTCATCCCCGCGGGT	GCGGGGAACCGTAGCCCGGACCCCACTGCACGATCCGCCCGTC
CGGTTCATCCCCGCGGGT	ACGGGGAACAGGCCGCCTTTTTCAGCGCCCGGCGCATCACCGC
CGGTTCATCCCCGCGGGT	GCCGGGAACAGCTGGCCGCGTCTTTCAAGATCCGTTCGGTGCG
CAGTTCATCCCCCGGGTG	CGGGGAACAGCAGCGAGTGCGCAGATTTGTTGAAATAAGGGG
CGGTTCATCCCCGCCGGT	GCGGGGAACAGAGTGCGGTCATGGTGACGGCCGAGCGGTTTAT
CGGTTCATCCCCGCGGGT

>NC_022041|2|3|2474044-2474131|CRISPRCasFinder
	CGTAGCCCGGACCCCACTGCACGATCCGCCCGTC
CGGTTCATCCCCGCGGGTACGGGGAAC	AGGCCGCCTTTTTCAGCGCCCGGCGCATCACCGC
CGGTTCATCCCCGCGGGTGCCGGGAACAGCTGGCCGCGTCTTTCAAGATCCGTTCGGTGCGCAGTTCATCCCCCGGGTGCGGGGAACAGCAGCGAGTGCGCAGATTTGTTGAAATAAGGGGCGGTTCATCCCCGCCGGTGCGGGGAAC	AGAGTGCGGTCATGGTGACGGCCGAGCGGTTTAT
CGGTTCATCCCCGCGGGTGCGGGGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022041.1\|WP_020951084.1\|2463480_2463960_+\|ribonuclease-HI	unknown	unknown	gnl\|CDD\|178927
NC_022041.1\|WP_041527877.1\|2465867_2466839_+\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020951092.1\|2474421_2475186_+\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_041527325.1\|2462805_2463411_+\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|223698
NC_022041.1\|WP_020951089.1\|2467972_2470975_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237514
NC_022041.1\|WP_020951085.1\|2463959_2464631_+\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NC_022041.1\|WP_148292620.1\|2482766_2483186_-\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020951093.1\|2475182_2475533_+\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020951099.1\|2482327_2482669_+\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020951090.1\|2471896_2473258_+\|NADP-specific-glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|181834
NC_022041.1\|WP_148292619.1\|2474182_2474419_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	cas2	cd09755_cas2_CAS-I-E	gnl\|CDD\|236930
NC_022041.1\|WP_020952479.1\|2479306_2480035_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|366760
NC_022041.1\|WP_041527328.1\|2478546_2479008_+\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020951088.1\|2466902_2467973_-\|L-glyceraldehyde-3-phosphate-reductase	unknown	unknown	gnl\|CDD\|381376
NC_022041.1\|WP_041527326.1\|2464646_2465048_-\|group-III-truncated-hemoglobin	unknown	unknown	gnl\|CDD\|381257
NC_022041.1\|WP_020951094.1\|2475602_2476460_-\|protein-L-isoaspartate(D-aspartate)-O-methyltransferase	unknown	unknown	gnl\|CDD\|234689
NC_022041.1\|WP_020951081.1\|2461184_2461733_+\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028
NC_022041.1\|WP_020951082.1\|2461789_2462740_+\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	unknown	unknown	gnl\|CDD\|234893
NC_022041.1\|WP_020951098.1\|2481779_2482331_+\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_148292561.1\|2477304_2478392_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|366234

Protein	Function_ID	Function_description	E-value
NC_022041.1\|WP_020951084.1\|2463480_2463960_+\|ribonuclease-HI	gnl\|CDD\|178927	PRK00203, rnhA, ribonuclease H; Reviewed.	9.86038e-92
NC_022041.1\|WP_041527325.1\|2462805_2463411_+\|glutathione-S-transferase-family-protein	gnl\|CDD\|223698	COG0625, Gst, Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	1.17321e-29
NC_022041.1\|WP_020951089.1\|2467972_2470975_-\|isoleucine--tRNA-ligase	gnl\|CDD\|237514	PRK13804, ileS, isoleucyl-tRNA synthetase; Provisional.	0
NC_022041.1\|WP_020951085.1\|2463959_2464631_+\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	2.63519e-55
NC_022041.1\|WP_020951090.1\|2471896_2473258_+\|NADP-specific-glutamate-dehydrogenase	gnl\|CDD\|181834	PRK09414, PRK09414, NADP-specific glutamate dehydrogenase.	0
NC_022041.1\|WP_148292619.1\|2474182_2474419_-\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|236930	PRK11558, PRK11558, putative ssRNA endonuclease; Provisional.	4.06531e-39
NC_022041.1\|WP_020952479.1\|2479306_2480035_-\|ATP-binding-protein	gnl\|CDD\|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	5.59076e-63
NC_022041.1\|WP_020951088.1\|2466902_2467973_-\|L-glyceraldehyde-3-phosphate-reductase	gnl\|CDD\|381376	cd19150, AKR_AKR14A1, Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins. Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.	0
NC_022041.1\|WP_041527326.1\|2464646_2465048_-\|group-III-truncated-hemoglobin	gnl\|CDD\|381257	cd08916, TrHb3_P, Truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 3 (P). The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or the T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. They are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). TrHb3s include Campylobacter jejuni Ctb, encoded by Cj0465c, which may play a role in moderating O2 flux within C. jejuni.	4.55424e-44
NC_022041.1\|WP_020951094.1\|2475602_2476460_-\|protein-L-isoaspartate(D-aspartate)-O-methyltransferase	gnl\|CDD\|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	3.39593e-09
NC_022041.1\|WP_020951081.1\|2461184_2461733_+\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	1.04562e-98
NC_022041.1\|WP_020951082.1\|2461789_2462740_+\|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	gnl\|CDD\|234893	PRK01045, ispH, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed.	1.9502e-171
NC_022041.1\|WP_148292561.1\|2477304_2478392_+\|IS3-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	5.47952e-29

>NC_022041.1|WP_020951090.1|2471896_2473258_+|NADP-specific-glutamate-dehydrogenase
MTILDDKLEPIFDEVVRRNAGEPEFHQAVREVLESLGRVVAKRPDYLEDALIERICEPERQIIFRVPWTDDKGKVHINRGFRVQFSSAMGPYKGGLRFHPSVNVGIIKFLGFEQIFKNALTGLPIGGGKGGSDFDPKGKSDGEIMRFCQSFMTELYRHLGEYTDVPAGDIGVGAREIGYMFGQYKRLTNRYEAGVLTGKGLFYGGSLARKEATGYGNTYFTRAMLQATGTDFDGKKVVVSGSGNVAIYTIEKVQEFGGKVIACSDSSGYIVDENGIDLALLQEIKEVRRGRVGEYARIKGEGNGVYFVKAADGNIWDVPCEVAMPSATQNELTGKDAKKLVKNGVMAVGEGANMPSTPEAIRTFQQAGVKFGPGKAANAGGVATSALEMQQNASRDKWTFDKTEARLADIMRDIHDSCYQTAEEFGAPGDYVIGANIAGFIRVAEPMRAFGII
>NC_022041.1|WP_020951089.1|2467972_2470975_-|isoleucine--tRNA-ligase
MSEPTSTAPDYRDTVFLPETEFPMRAGLPAREPDWLARWEALDIYGRLRRKGKEAGRAPFILHDGPPYANGNLHIGHALNKVLKDFITRSQQMMGRDARYVPGWDCHGLPIEWKIEEQYRERQQRKDDVDIVEFRQECRAFAQGWVETQREQFKRLGVIGNWEDPYLTMNYHAEAVIAAEFMKLLMNGSLYQGSKPVMWSPVEQTALAEAEVEYHDHTSHTIWVRFKPVGASGDSHIAKGAGLTVDPGLSDQIEAEVLQDMKDELLQASIVIWTTTPWTIPQNRAVAFGPDIDYGLYEVTDVEDKSTAVLGEYLVLADALAEGVLKSAKVTGFNRLREVTADELRGLILAHPYRGIENGQGEWDFDVPLLPGDHVTEDAGTGFVHTAPSHGDDDYQLGVKYKLPMTYNVEPDGSYRKDLPVFGGEAILTSTGAEGSANVSNIKQLAYAGALLAKGKIKHSYPHSWRSKAPVIYRNTPQWFAAIDTDLSDGMNEYGSTIRSRALTSIDKLVRWTPQTGRNRIHSMVENRPDWVLSRQRAWGVPLTVFTKKGARPTDADFLLKDARLNDRITAAFEKDGADAWYRDGFKAQVLEGIANPDDHDQVTDVLDVWFDSGSTHAFVLRDRADGTPDGIADLYLEGTDQHRGWFQSSLLQACATKGRAPYKGVLTHGFTLDEKGMKMSKSLGNVILPAEVIKDYGADILRLWVAQADYTADQRIGKEILKGTADSYRRLRNTLRYMLGSLAGFTEAERVEPAEMPELERWVLHRLAEIDAQVRHGYDVYDFQGVFQTLFQFATLDLSSFYFDIRKDALYCDGPDSLRRRAARTVLDILFHRLTTWLAPILPFTMEDVWLSRFPGDDSSIHLQDFVATPHDWLNADLARKWDQVRRARRVVTAALELKRTDKTIGASLEAAPVVHVEDAALLSALKSSDFADICITSDLSLTADPAPAEAFRLSEVPGIGVVFEPAEGEKCERCWRILPDVGTHQHPGTCARCDEVLS
>NC_022041.1|WP_020951088.1|2466902_2467973_-|L-glyceraldehyde-3-phosphate-reductase
MAERPAKPLVAGWQPDPERHERMTYRRTGRSGLMLPAVSLGLWHNFGEDTPHQVKRAICRAALDCGITHFDLANNYGPPPGSAETAFGEILRTDFAGLRDELIISSKAGYRMWDGPYGEWGSRKYLIASCDASLKRLGLDYVDIFYSHRFDPETPLEETMGALDHIVRSGRALYVGISSYNAHRTAEAVAILRELGTPCIIHQPSYNMLNRWVEGDGLLNTLESLGVGSIAFTPLAQGMLTGKYLRGIPDGSRAAQGKSLFPEWLTDKALGALRGLNDLAEARGQTLAQMAIAWVLRGGHVTSALIGASRPEQVIDCAGAIRNLDFSAAELARIDQLVADCGDVNLWAQSSEGAGG
>NC_022041.1|WP_041527877.1|2465867_2466839_+|hypothetical-protein
MLIVAQNGTLAREAVLFAASLRRNSPNWQGQLIVAEPLPEGAWSGARTRIPDAERALLTGYGAEILPFTARHFGRAYPYGNKIEALALLPAKENFIFFDTDTLILGPLDQIAFNFARPSASMRREGTWPEPPLYGPGYAEIWKSLYDRFQLPFETSLDPTRSEDDWERYLYFNAGWFFGSDPDLFGRRFLDAALKVQADPGEALACQSLDPWLDQATLPLVIHSFLGGRPGPELDGLDGAVTCHYRNLSLLYAREPEAALSEVETLLADPKIAALFAQDAGAQKLVVQGEGRKVLRPLFAGGLPPSEKAMRQVLKRSELWFPQ
>NC_022041.1|WP_041527326.1|2464646_2465048_-|group-III-truncated-hemoglobin
MVTPRFDITPAEIDRVIAVFYAAIRRHETLGPVFAGHITDWPEHEAKIAAFWRNAILREGGYDGSPMRAHMQAGDVRAPHFAPWLMLFDESLRRCLPPEAAQGWSALAHRIGAGLRMGVEDFHARGSAPPRLV
>NC_022041.1|WP_020951085.1|2463959_2464631_+|trimeric-intracellular-cation-channel-family-protein
MISEVGLSEVQIFLDYASVFIFALTGALVASRGQLDIVGFIFFAVLTAVGGGTVRDLLLGREVIFWVARPNLILAAVAAALIVFLTAHRLESRYRTLLWLDALALAVAVPAGVDFAIGAGYGAIIVAMAGVITASAGGLMRDVISNEVPLVLKQGELYLTAAFGGAITVLALDRLGFPHGWGLIACGAVTFGLRAGSMVWGWQLPVYKRRAPKVQPGVDPRDP
>NC_022041.1|WP_020951084.1|2463480_2463960_+|ribonuclease-HI
MTELFAWTDGACSGNPGPGGWGVLLRAMNGAEIVKERELKGGEADTTNNRMELMAAIAALETLARPAELTITTDSAYVKNGVTQWMFGWKKKGWRTADNKPVKNIDLWQRLEAAQARHTVTWKWIKGHAGHAENERADELARAGMTPFKPEKAAAERGA
>NC_022041.1|WP_041527325.1|2462805_2463411_+|glutathione-S-transferase-family-protein
MTLYSMPSSGNSYKVRLLLALIGRDCAIVDVEDSSPEIAAAKAAGRLPFGKAPVLELADGRLLPESNAILMWLGQGTAFIPGDAYQQAEMLSWMFWEQNQHEGVIAVRGALLFYPSRKTLATPERLAELLERGYGLLQILEDRLAGRDWLVGESLSLADLALYGYTHTAGSRGQYDMSRFPAINRWCDRIAALPGYIGLYD
>NC_022041.1|WP_020951082.1|2461789_2462740_+|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase
MTEKPKLTLYLAAPRGFCAGVDRAIKIVELALSKWGAPVYVRHEIVHNKFVVDSLRDKGAVFVEELSECPDDRPVIFSAHGVPKSVPAEARAREMVFVDATCPLVSKVHVEAERHHQAGLQMVMIGHIGHPEVLGTMGQLPEGEVILVETVEDVATLAPRDPERLAFITQTTLSVDDTAAIVAALQARFPAIIGPAKEDICYATTNRQAAVKAIAPKIEALLVIGAPNSSNSRRLVEVGKASGCAYSQLVQRAEHIDWRALSGIRSVGVTAGASAPEVLITEVLDAFRERFDVTIDIVETARENVEFKVPRVLREA
>NC_022041.1|WP_020951081.1|2461184_2461733_+|adenine-phosphoribosyltransferase
MSPRHAQKSVKDYIRTIVDFPKEGIIFRDVTTLFQDARGFRMAVDQLLSPYAGEQIDKVVGLEARGFILGGAVAHQLTVGFVPIRKKGKLPGAVLSEAYQLEYGEAVMEIHDDAIKPGERVLIVDDLLATGGTAKAAIKLCERLGAEVIGCAFVIDLPDLGGRKLLEDGGVDVFSLVSYDGA
>NC_022041.1|WP_148292619.1|2474182_2474419_-|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MVEVRAGVYVGDCSARTREMIWSQVTGGIEQGDAVMIWSAPTDQGDAFETTGRNRRMPVDFDGLKLVSFFPRDDGNNR
>NC_022041.1|WP_020951092.1|2474421_2475186_+|hypothetical-protein
MRQGGRADGAAGEVSALKGARFSWTSPEIGAHYGLGPGKIAIHLALEGAIRDASGAVTGIRNLGGAGAVFDATRTGPASPLSDGMLDFRGEAATHFATALPADLNDVTLMSAFRLADFAVASRWLGANGLEFRSNPSAQGWFIQIWSNLGGGGGAGNIIGSRLPNIDQVVIAEHAFAAGRVVTRVNGVQIGSSPIPSSVPQPGPLPLQFVGKGSGSNGFRGLIGDVLGITHGPNLAGVEAVARRTLAAKFGVAL
>NC_022041.1|WP_020951093.1|2475182_2475533_+|hypothetical-protein
MIEIIRELLTPEDHTDPYVWAAVFVAHAAIGVALWALLAGLTRRPLLWAAALYAAFEALQATVAGELLFWDSALDWTGVMLGAALASSLWAQRLGRASAAIIATLAIAVAGWRKRE
>NC_022041.1|WP_020951094.1|2475602_2476460_-|protein-L-isoaspartate(D-aspartate)-O-methyltransferase
MKPEAVELSRCPDEIAQIAVAGLQLSEAALQSQLVQSQHRARIALAWDVREGQRLLELGCGQGDMTAVLAAMVGSSGHVTAIDPGSPDYGAPVTLGEAIARLTAGPLGGRLNVQLGTGLSSPTLALPFEHYDAAVMAHCSWYFASQDSLVETFSCLAGRTRQLLLSEWDIRAESPSQIPHLLTVLLRRALSVPLPDDNIRTPISQTEMIALLSQAGWSVEQVTEIDSNQLQDGGWEVDMMLDRLLHDPALGSVQLMSDTNLEKLRTALLRSQIESMPSYALVCRR
>NC_022041.1|WP_148292561.1|2477304_2478392_+|IS3-family-transposase
MRKSRFTEPQIMAVLRQAESGVAVPELCREHGISTASFYKWRSKYGGMDASMMSQMKTLEDENRRLKRMFADLSMQAELLKEALGKKLTRPVQRRELAEKAVATKGVSIALACRAFGVSETCFRYSPKRDAENEFIADLLEGLTKVHRTWGFGLCFLHMRNVQGHPWNHKRVHRIYCELELNLRIKPRRRIKRDKPEELSVPDAPNTVWSMDFMADRLADGRQFRLLNVLDDFNREGLGIEVDFSLPAERVVRSLNQIIEWRGKPLAIRVDNGPEYISSTLMIWAEKQGIAHNHIQPGKPQQNAYVERYNRTVRNEWLDLYIFETIEEAQEIATDWLWTYNNERPNMGIGGITPAQKLKMAA
>NC_022041.1|WP_041527328.1|2478546_2479008_+|hypothetical-protein
MMKARTLAVMSLAILAGCSSEDAKLHSKTIAGGGRAISVLGSTTYEMSGEDFGNGNVGLYNIRSADKGPVSGRFSLINCQTAKITRVELVEPPGDIRDIIEKIRKAGGLSSPARLAADAMSYGLAATTGQVKRGEYSQGTRAANACTLFYGSE
>NC_022041.1|WP_020952479.1|2479306_2480035_-|ATP-binding-protein
MERTQILDLMGTLKLYGMRSAYDEVMAAGIKRQHEPPRIVGDLLQSEIAEKLARSIRYQLTVAKLPLAKDIEEFDFTGTPINEGLVRDLSTGSFVSDQRNVVLIGGAGTGKTHLAIAIARALIRGGTRGRFFNVVDLVNRLETETRNGKQGRMADYLTRLDFVILDELGYLPFAQSGGQLLFHLISRLYERTSIIVTTNLAFGEWPTVFGDAKMTTVLLDRLTHHCEIIETGNESWRFKNRA
>NC_022041.1|WP_020951098.1|2481779_2482331_+|hypothetical-protein
MPLAGTPAPDSVPGALAFRGTVLGAAHAGSGPRYGIVAIRLLAPAVNTSRPVLQWVNDLATSWNAPCILFELNAWTARYALSDGGQEATQAAYAIGSWQVVEFWITPEALGTAVAGGPSSTVARAAPIPATTGLMLGGGTSFGGPDNPADFDLAGLFLCDGVPTSDQRARLRAWARAQIPEVT
>NC_022041.1|WP_020951099.1|2482327_2482669_+|hypothetical-protein
MIRELLTPEDHADPYAWAAVFVAHAAIGVALWALLAGLTRRPLLWAGLLYAAFEALQATVAGELLFWDSALDWTGVMLGAALASSLWAQRLGRASAAIIAALAIAVAGWRKRE
>NC_022041.1|WP_148292620.1|2482766_2483186_-|hypothetical-protein
MRFWPIAVIIFLTGCLDEDLADRFLADESLRSLSPLAAESRIFFCAVAVYSTSPLSDPPELTGNFEPWSTIPLSERVHAEAIEMRAISNECWDEDIQRATEAADPWEYLDAAKPTNSFDHAGNVALFDPKRNIFIAISG

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Crispr_ID: NC_022041_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022041_3

2655481-2655796

Orphan

Consensus_repeat	Method
CCCCCTCCTCCTCCCTGGGGTCGC	CRISPRCasFinder
CCNCTCCTCCTCCCTGGG	CRT

6 spacers

The CRISPR arrays of NC_022041_3

>merge|NC_022041|3|2655481-2655796|CRISPRCasFinder,CRT
CCCGCTCCTCCTCCCTGGGGCCGGGTTCAGGCGACATCCTCCTCCTCCTCCCTGAGGATGTCGCCGCACCAACACGGAAGCCCTCTCCTCCTCCCTTGGGCTTCGTGTCAAGGCGGCGACCCCCTCCTCCTCCCTGGGGTCGCCGCACTTTCTCCGCCGCAGGGCGGACCAGAATACGATGGCCCCCTCCTCCTCCCTGGGGTCGCTCGTGAGCGGTAATGGCACTCCTCCTCCCAGCCATTGCCGCACCCTATACGCGGCCCCTCCTCCTCCCTGGGCCAGCGTTGCGCGGCGGTGCCCCCTCCTCCTCCCTGGG

>NC_022041|3|4|2655481-2655763|CRISPRCasFinder
CCCGCTCCTCCTCCCTGGGGCCGG	GTTCAGGCGACATCCTCCTCCTCCTCCCTGAGGATGTCGCCGCACCAACACGGAAG
CCCTCTCCTCCTCCCTTGGGCTTC	GTGTCAAGGCGGCGA
CCCCCTCCTCCTCCCTGGGGTCGC	CGCACTTTCTCCGCCGCAGGGCGGACCAGAATACGATGG
CCCCCTCCTCCTCCCTGGGGTCGC	TCGTGAGCGGTAATGGCACTCCTCCTCCCAGCCATTGCCGCACCCTATACGCG
GCCCCTCCTCCTCCCTGGGCCAGC

>NC_022041|3|2|2655482-2655796|CRT
CCGCTCCTCCTCCCTGGG	GCCGGGTTCAGGCGACATCCTCCTCCTCCTCCCTGAGGATGTCGCCGCACCAACACGGAAGC
CCTCTCCTCCTCCCTTGG	GCTTCGTGTCAAGGCGGCGAC
CCCCTCCTCCTCCCTGGG	GTCGCCGCACTTTCTCCGCCGCAGGGCGGACCAGAATACGATGGC
CCCCTCCTCCTCCCTGGG	GTCGCTCGTGAGCGGTAATG
GCACTCCTCCTCCCAGCC	ATTGCCGCACCCTATACGCGG
CCCCTCCTCCTCCCTGGG	CCAGCGTTGCGCGGCGGTGC
CCCCTCCTCCTCCCTGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022041.1\|WP_020951267.1\|2659937_2660225_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NC_022041.1\|WP_020951253.1\|2646600_2647986_-\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	unknown	unknown	gnl\|CDD\|184501
NC_022041.1\|WP_041527903.1\|2652590_2653106_-\|division/cell-wall-cluster-transcriptional-repressor-MraZ	unknown	unknown	gnl\|CDD\|234728
NC_022041.1\|WP_020951262.1\|2656641_2657070_-\|GFA-family-protein	unknown	unknown	gnl\|CDD\|226314
NC_022041.1\|WP_020951256.1\|2651284_2651623_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227749
NC_022041.1\|WP_041527905.1\|2660412_2661105_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
NC_022041.1\|WP_020951255.1\|2649482_2651288_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|223839
NC_022041.1\|WP_020951270.1\|2662602_2663382_-\|succinate-dehydrogenase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|235652
NC_022041.1\|WP_041527348.1\|2655237_2655465_+\|DUF1127-domain-containing-protein	unknown	unknown	gnl\|CDD\|368980
NC_022041.1\|WP_148292672.1\|2657232_2657787_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|225567
NC_022041.1\|WP_020951257.1\|2651625_2652594_-\|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH	unknown	unknown	gnl\|CDD\|234597
NC_022041.1\|WP_041527350.1\|2661657_2662407_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|237252
NC_022041.1\|WP_041527349.1\|2655840_2656617_+\|23S-rRNA-(adenine(2030)-N(6))-methyltransferase-RlmJ	unknown	unknown	gnl\|CDD\|225509
NC_022041.1\|WP_020951254.1\|2647982_2649467_-\|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	unknown	unknown	gnl\|CDD\|234660
NC_022041.1\|WP_020951268.1\|2661139_2661469_-\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020951265.1\|2658459_2659941_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NC_022041.1\|WP_020951259.1\|2653812_2654907_-\|Mrp/NBP35-family-ATP-binding-protein	unknown	unknown	gnl\|CDD\|378455
NC_022041.1\|WP_020951251.1\|2644002_2645406_-\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	unknown	unknown	gnl\|CDD\|234950
NC_022041.1\|WP_041527904.1\|2657861_2658431_-\|hypothetical-protein	unknown	unknown	unknown
NC_022041.1\|WP_020951252.1\|2645515_2646598_-\|phospho-N-acetylmuramoyl-pentapeptide--transferase	unknown	unknown	gnl\|CDD\|234638

Protein	Function_ID	Function_description	E-value
NC_022041.1\|WP_020951267.1\|2659937_2660225_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	1.6076e-36
NC_022041.1\|WP_020951253.1\|2646600_2647986_-\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	gnl\|CDD\|184501	PRK14093, PRK14093, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional.	7.29314e-138
NC_022041.1\|WP_041527903.1\|2652590_2653106_-\|division/cell-wall-cluster-transcriptional-repressor-MraZ	gnl\|CDD\|234728	PRK00326, PRK00326, transcriptional regulator MraZ.	1.87543e-35
NC_022041.1\|WP_020951262.1\|2656641_2657070_-\|GFA-family-protein	gnl\|CDD\|226314	COG3791, COG3791, Uncharacterized conserved protein [Function unknown].	2.70403e-24
NC_022041.1\|WP_020951256.1\|2651284_2651623_-\|hypothetical-protein	gnl\|CDD\|227749	COG5462, COG5462, Predicted secreted (periplasmic) protein [Function unknown].	2.21914e-06
NC_022041.1\|WP_041527905.1\|2660412_2661105_+\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	2.82189e-77
NC_022041.1\|WP_020951255.1\|2649482_2651288_-\|penicillin-binding-protein-2	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	4.66309e-129
NC_022041.1\|WP_020951270.1\|2662602_2663382_-\|succinate-dehydrogenase-iron-sulfur-subunit	gnl\|CDD\|235652	PRK05950, sdhB, succinate dehydrogenase iron-sulfur subunit; Reviewed.	1.0174e-171
NC_022041.1\|WP_041527348.1\|2655237_2655465_+\|DUF1127-domain-containing-protein	gnl\|CDD\|368980	pfam06568, DUF1127, Domain of unknown function (DUF1127). This family is found in several hypothetical bacterial proteins. In some cases it represents it represents the C-terminal region whereas in others it represents the whole sequence.	2.15734e-09
NC_022041.1\|WP_148292672.1\|2657232_2657787_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|225567	COG3023, ampD, N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane].	2.27746e-48
NC_022041.1\|WP_020951257.1\|2651625_2652594_-\|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH	gnl\|CDD\|234597	PRK00050, PRK00050, 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH.	1.43498e-141
NC_022041.1\|WP_041527350.1\|2661657_2662407_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|237252	PRK12896, PRK12896, methionine aminopeptidase; Reviewed.	4.70472e-128
NC_022041.1\|WP_041527349.1\|2655840_2656617_+\|23S-rRNA-(adenine(2030)-N(6))-methyltransferase-RlmJ	gnl\|CDD\|225509	COG2961, ComJ, Protein involved in catabolism of external DNA [General function prediction only].	2.33932e-75
NC_022041.1\|WP_020951254.1\|2647982_2649467_-\|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	gnl\|CDD\|234660	PRK00139, murE, UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional.	0
NC_022041.1\|WP_020951265.1\|2658459_2659941_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NC_022041.1\|WP_020951259.1\|2653812_2654907_-\|Mrp/NBP35-family-ATP-binding-protein	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	4.76937e-140
NC_022041.1\|WP_020951251.1\|2644002_2645406_-\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	gnl\|CDD\|234950	PRK01390, murD, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional.	0
NC_022041.1\|WP_020951252.1\|2645515_2646598_-\|phospho-N-acetylmuramoyl-pentapeptide--transferase	gnl\|CDD\|234638	PRK00108, mraY, phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional.	0

>NC_022041.1|WP_041527348.1|2655237_2655465_+|DUF1127-domain-containing-protein
MAVLDLNHGTVRGTTATAGGASGFFGALAGYFARRSLYRQTVNELNQLSDRELADLGINRLDITSIAASAVKGQR
>NC_022041.1|WP_020951259.1|2653812_2654907_-|Mrp/NBP35-family-ATP-binding-protein
MSVSRETVLNELGRIAVPGGGTLISRDLVRALAIEDDTVRFVIEVEDAAAARAFAPVEAEAQRALKALAGVGKVQIVLTAPTAPRGQAQPAAKPAGAPPNLTIGRHPTPQAGPADVAGVKRIIAIGSGKGGVGKSTVTSNLAVALAKKGRKVGVLDADIYGPSQPRMLGVTDRPKSDGETIEPLHAHGVTLMSLGLLMKEGEAVVWRGPMLMGALQQMLTQVKWGELDVLLVDLPPGTGDVQLSLCQKTNVSGAIIVSTPQDVALIDARRAIDMFNKLKTPILGMVENMSMYICPNCGHEAHLFGHGGVAAEARRLDLPFLGEIPLELEVRLAGDAGRPVAAGEGAVSDAYGRLADRLIGGGMA
>NC_022041.1|WP_041527903.1|2652590_2653106_-|division/cell-wall-cluster-transcriptional-repressor-MraZ
MARRFRGTEEVKVDAKGRISIPAKFRRVFESADPDWTDSNSRPQLVIVYGTKEQNYLALYTIEAIEEIDTLISQLPRGSSRRIYLETVVNGLSEESEIDNDGRLGLPQKLREKIGLSDRAVFMASGDHLKLWTPENYTAEIERIEAQIPELEPGADPLSLLPSRDEPGGAQ
>NC_022041.1|WP_020951257.1|2651625_2652594_-|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH
MSTETEPHIPVLLNPILRAVAPVHGIWADGTFGAGGYSRGLLDAGAAQVVGIDRDPSVFRMAESWSGQYGDRLKLVEGTFSDLDRLAGEPLDGVVLDLGVSSMQLDQAERGFSFLRDGPLDMRMSDTGPTAAELLNTAEEKTIADVLYHYGEERASRRIARAIVNARPLTRTAQLAEVVASCLPRPKPGQSHAATRSFQAIRIWVNDEFGQLVAGLAAAERGLKEGGQLAVVTFHSLEDRIVKRFMQQRSNSAGGGSRYAPVAETAAAAFTLPFRRAIGPDDSELDVNPRARSALLRVAIRTAAPAGHVDPAVLGLPVLPGR
>NC_022041.1|WP_020951256.1|2651284_2651623_-|hypothetical-protein
MRSILYLTTALVVMGLAFWAYRENYRTQDAIRKMEAIQYQIGGLRQDIGTLRAEWSYLNRPDRLRELVNLNFDKLKLVPLNSDQFVDIRQVAYPAKTVAAPDAGTPAEESTP
>NC_022041.1|WP_020951255.1|2649482_2651288_-|penicillin-binding-protein-2
MIRKPLRPLARILKARETGENPDDIEAENRAIRHAEMQDRARKSAQNRLMLLASVFVVAFGTVGLRMGALASGQPSEPRVQSSGAQIISQRADITDRNGRVLATNLLTHSLYAHPQQMIDPDRAATELARIFPDLNEERLHKDFTGKRTFLWIKKKLSPEQMQAVHDIGEPGLLFGPREMRLYPNGHLASHILGGATFGNEGVSSAEVLGMAGVEKAFDNWLRDPANEGAPLKLSIDLSAQAAMEEVLSNGMKVMNAKGATAIFMEIKTGEIIAMASLPDFDPNDRPRPLLKGDASDSPLFNRAVQGQYELGSTFKIFPVAQAIDAKLINPKTMINTQSPMKIGKYLIHDFHNYGGQLSVADIIAKSSNVGTVRIAQMLGVERQKDFLQKLGFFEPTPIEMTEGPTGKPLVPQRWPAVTSATVAFGHGLAASPLHLASAYATIANDGKRVRPTLIHGHKHPEGERLISSGAAKVAIDLLRGVVTRGSARSSNVVGYEIAGKTGTADKPRPTGGYYKNKVVATFASVFPASAPEYVLVVTLDEPSTGTAGGGESRVAGLTAVPVAAELIRRLAPLVGLRPQTESTLPVIEPRAPDGLKLVAN
>NC_022041.1|WP_020951254.1|2647982_2649467_-|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase
MSETAKRLSLLGLRGDKGRDPEVTGLAVDSRQVKPGYLFAALPGSSAHGASFIQYALRLGAAAVLTDREGAALAAAELSGAEAALVVVEDPRAALAAAAALWFGAQPETLVAVTGTSGKTSVATFTRQIWQLLGEQAISLGTMGVQGDYEAKLAHTTPEPITLHRVLAEAAAAGVTHACMEASSHGLDQRRLDGVRVLAGAFTNFTQDHLDYHKNFDEYFAAKALLFNHILEEGASAVINIDDPRGLQLLAIAQARGLKIIRVGRSPEADLRILGQRYDATGQDLRFSIFGKTHMVRLALIGGFQAENVLAAAGLVIATGTDPDAVVAVLPRLTTVRGRMELAAMRENGAAVFVDYSHKPGALASALQSLRPHVMGRIVVIFGAGGDRDRLKRPLMGEAARDFADVVFVTDDNPRSEDPAAIRAEVMAGAGPDAIEVGDRAEAILRGVDALQPGDALLIAGKGHETGQIIGNDIFPFDDSEQASVAVAALDGKI
>NC_022041.1|WP_020951253.1|2646600_2647986_-|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase
MTALWTAAEAEAATGGKASGSWTVTGVSIDTRTIAPGDLFVALKAERDGHDFVAQALAKGAGAALVSRIPEGVASDVPLLIVDDVLDGLTALGRAGRARVSGKVIAITGSVGKTSSKEMMRAGLAGQGRIHAAEASYNNHWGVPLTLARMPAETDFAVIEIGMNHPGEIEPLARLARPHVALITTVAAVHLEAFGVVEGIAREKGAIFAGLEAAGTAILPEDLAVTPILRDAADEAGAIVIGFGAHGMGQLLKSEAMGEEMRVRARILGKVVDYTLQSAGAHFAMNSVGVLTALHAAGIDVAEAARGLSVWRPFQGRGALEDLGDIRLIDDSYNSNPTSLSAGLATLARLDGGRRIAILGDMLELGPETVEMHRAMAEDPAIAAVALIHSAGPLMRHLHEALPAEKRGIWVETAAELAARVSELAQTGDIVLVKGSKSSKVSTVVDALRRSLQSSAPENRG
>NC_022041.1|WP_020951252.1|2645515_2646598_-|phospho-N-acetylmuramoyl-pentapeptide--transferase
MLYWLTSLSDGGDFFNLFRYITFRAGGAFFTALIFGFIFGRPLIDLLRRHQKKGQPIRDDGPQSHLAKAGTPTMGGLLILAALTVGTLLWARLDNGYVWIVLLVTLAFALIGFADDYAKVTKQHHAGLSGRVRMALGFVIAAIAGFSAAALHPDALSHQLAIPFFKNAFINLGIFYIPFAMFVIVGAANAVNLTDGLDGLAIMPVMIASATFAIIAYMVGNANFSTYLGLHFVPGSGELAVFCAALIGGGLGFLWYNAPPAAVFMGDTGSLALGGALGAIAVVTKHEVVLAIVGGLFVVEALSVIIQVLYFKRTGRRVFLMAPIHHHFEKKGWGEAQIVIRFWIIALILALIGLATLKIR
>NC_022041.1|WP_020951251.1|2644002_2645406_-|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase
MIPVQGVQNQTIAVLGLGRSGRATAAALTEGGADVVVWDDGADTRASAEAEGLTLRDLTRETAWEGVSALITSPGIPHLYPKPHPAIAMALRLGIPVDNDIGLFFRSFATRDWDSFDITPRVIAVTGSNGKSTTTALIHHILTEVGRPAQMGGNIGTGVLSLDPAQDGEVVVLELSSYQTDLARALTPDVAVFTNLSPDHLDRHHGMGGYFAAKRRLFAEGGPDRAVIGVDEIEGLYLADQLSEGPQDDRVIRVSSETKLDAFGWSVFAKKGFLSEYRKGRQVASIDLRAVTGLPGAHNHQNACAAYAACRAVGIPPREIEAAFHSFQGLPHRSQTVAEIGGVRWVNDSKATNVDSAEKALLAFKNIRWIAGGMGKEGGITSLVPHLGNVVKAYFIGHSARDFALEVGQSVDYEIFATIDEAVARAHAEAQSGETVLLAPAAASFDQFPNFEKRGEHFTALVQALKG
>NC_022041.1|WP_041527349.1|2655840_2656617_+|23S-rRNA-(adenine(2030)-N(6))-methyltransferase-RlmJ
MLSYQHAYHAGNLADFQKHALLAWMLAYLTDKPKPMTYIETHAGRGLYDLGGDEARKTGEAEAGISRALTEGWLPETHPLRQVLASVRREYGPDAYPGSPLIAETLLRPDDVIHLAELHPAEADALADAAPFAHLHREDGFAMANALCPPMPRRGLLLIDPSFEVKADYDRIPRFIGQIARKWNVGVIALWYPLLADARHGPMLKALQVAFPEALRHEVQFPPARPGHGMVGSGMFVVNPPFGIDEETRRLDAIFAGL
>NC_022041.1|WP_020951262.1|2656641_2657070_-|GFA-family-protein
MTLDLDLTESTGACHCGAVRFHVRLSEGLRSARRCNCSFCQMRGAIAVSARVGELEILQGADALTLYQFGTSTAKHYFCRHCGIYTHHQRRSNPQEYGVNIACLTGLSPFDFTEVEVLNGREHPSDKANGREVVGVLRFEPS
>NC_022041.1|WP_148292672.1|2657232_2657787_-|N-acetylmuramoyl-L-alanine-amidase
MADGASARARLCDPSAEVSAHWLLHETGQAEALVPEDRRAWHAGAGEWRGQGDINSRSIGIEIINPGDRPFPEPQMRGLETLLAAILQRWSLRPEAVIGHSDMAPDRKIDPGAKFDWRRLALQGLSVWPETPGADLPLQDSLDAIGYPPGPPEIRLAAFRLRFRPGADGPEDEIDRRLAAAVPR
>NC_022041.1|WP_041527904.1|2657861_2658431_-|hypothetical-protein
MRKLAILGVMGLAVLGLSACNENAGWNPNYTMNASPYGEYQRARETALMTNTREPQVIPIQLPAQAPTPEDIAGKREVKAMVTTKVVPVQPAQVRVAPATRARVIASGDNAVLVRFAQTEKQNPGQARYARTGANPAQALKACSQFPNPAIAQTAFLANGGPILDPQNLDPDGDGFVCGWDPRPYRQGL
>NC_022041.1|WP_020951265.1|2658459_2659941_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MTDLNKLTIAAARDGLRAKDFTATELTEACLTAINGADKLNAFVHKTPEIAREMAARADARLASGDAPAMCGIPVGIKDVFCTKGVPSQAASRILEGFKPEYESTVTQNLWDAGAIMLGKLNMDEFAMGSSNESSVYGKAINPWKIDARDLTPGGSSGGSAAAVAADLCLAATGTDTGGSIRQPAAFTGTVGIKPTYGRVSRWGTIAYASSLDQAGPMTKTVRDAAIMLGAIASVDAKDSTSADRPVPDYEAALSGDIRGKKIGIPREYRIEGLNAEVDAVWNKAADMLRDAGAEIVDISLPHAKYALPAYYVIAPAEASSNLARYDGVRFGRRAKLGAGDGIVEMYERTRAEGFGPEVQRRVMIGTYVLSAGFYDAYYNRARKVRALIKRDFDQAYAAGVDAILAPATPSPAFGLGEMTGADPVEMYLNDVFTVTLNLAGLPGVSVPVGLSASGLPLGMQLIGRPWEEGELLNLAQVLENAAGFEAKPERWW
>NC_022041.1|WP_020951267.1|2659937_2660225_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MAITQDEARKVAHLARIAVKDADLPALAQELNGILHFMEQLTEVDVTGVEPMTGVEPMRLKRRQDVVTDGEMQDRILANAPDAREGFFAVPKVVE
>NC_022041.1|WP_041527905.1|2660412_2661105_+|metal-dependent-hydrolase
MKLTWLGHSSFRLEIEDAVILIDPWISQNPAFPHDRRAEAIAGATHILITHGHGDHASDTIALAKELDIPAVGIYDLISFWQAHHGIRGVGFNKGGTVDLGGAKVTMVNASHSSSLDGSNGPIYAGHESGYMIAGDGHVIYVSGDTDIMADMGWMGEYHRPDIGILCAGGHFTMDMERAAWAAKKYFDFKTVIPCHYKTFPFLAQSAAPMIEALPGVEVIEPEVMVPISL
>NC_022041.1|WP_020951268.1|2661139_2661469_-|hypothetical-protein
MRGVVKLLVVIVLIGLGFVYFSLGPSFLLGGPKNADIVAQARLALIVGAPTPAEADLARRADLSPQGLCNRSGDGSFACLVDVSVEGTLARTFVAVLRKDANGNWTATP
>NC_022041.1|WP_041527350.1|2661657_2662407_-|type-I-methionyl-aminopeptidase
MTITKEDELTRLREIGRIVADTLRAMTRATEPGITTRELDEIGRVFLEREGAVSAPQSAYDFPGATCISVNEEIAHGIPGARVIAAGDLVNIDVSASKNGYFADTGASFQVAPRHAALDQLCRDGRRAMEIGIAEVGAGKPLAGIGKAIGRFASDRGYTLIRNLASHGIGRALHEHPEAIPTWPERGEKRRINKGLVLTVEPFLSTGGQWAGEGDDGWTLYSEPCAPVVQYEHTVVATQRGAIVLTLPS
>NC_022041.1|WP_020951270.1|2662602_2663382_-|succinate-dehydrogenase-iron-sulfur-subunit
MVQFNLPKNSRIRVGKTWPKPDGAKNVKKFNIYRWDPDTGENPRLDTYFIDLDKCGPMMLDALIKIKNEIDPTLTFRRSCREGICGSCAMNIGGGNHLACIYGIDEVKGDVNIYPLPHMPVVKDLVPDLTHFYAQHASVHPYLITETPTPDKEWRQSIEDRKKLDGLYECILCASCSTSCPSYWWNGDRYLGPAALLAAYRWIIDSRDEATGDRLDELEDPFKLYRCHTIMNCTNTCPKGLNPAKAIASIKHMMVDRVV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022041_3	3.10\|2655759\|20\|NC_022041\|CRT	2655759-2655778	20	NZ_CP043475	Mycobacterium grossiae strain DSM 104744 plasmid pGP01, complete sequence	20224-20243	1	0.95
NC_022041_3	3.10\|2655759\|20\|NC_022041\|CRT	2655759-2655778	20	NZ_CP043475	Mycobacterium grossiae strain DSM 104744 plasmid pGP01, complete sequence	40658-40677	1	0.95
NC_022041_3	3.10\|2655759\|20\|NC_022041\|CRT	2655759-2655778	20	NZ_CP032156	Mycobacterium sp. ELW1 plasmid pELW1-1, complete sequence	56555-56574	1	0.95
NC_022041_2	2.1\|2473830\|32\|NC_022041\|PILER-CR	2473830-2473861	32	NZ_CP044066	Cupriavidus pauculus strain FDAARGOS_664 plasmid unnamed1, complete sequence	63522-63553	8	0.75
NC_022041_2	2.1\|2473830\|32\|NC_022041\|PILER-CR	2473830-2473861	32	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	2004414-2004445	9	0.719
NC_022041_2	2.5\|2474074\|32\|NC_022041\|PILER-CR	2474074-2474105	32	NZ_CP049358	Deinococcus wulumuqiensis R12 plasmid unnamed1, complete sequence	72247-72278	9	0.719
NC_022041_2	2.5\|2474074\|32\|NC_022041\|PILER-CR	2474074-2474105	32	NZ_CP031159	Deinococcus wulumuqiensis strain NEB 479 plasmid pDrdA, complete sequence	58209-58240	9	0.719
NC_022041_2	2.6\|2473828\|34\|NC_022041\|CRISPRCasFinder	2473828-2473861	34	NC_021347	Rhodococcus phage E3, complete genome	81587-81620	9	0.735
NC_022041_2	2.2\|2473891\|32\|NC_022041\|PILER-CR	2473891-2473922	32	MG592392	Vibrio phage 1.005.O._10N.286.48.F2, partial genome	15383-15414	10	0.688
NC_022041_2	2.3\|2473952\|32\|NC_022041\|PILER-CR	2473952-2473983	32	CP036421	Rhodobacter sphaeroides strain HJ plasmid unnamed1, complete sequence	75796-75827	10	0.688
NC_022041_2	2.5\|2474074\|32\|NC_022041\|PILER-CR	2474074-2474105	32	MF373841	Mycobacterium phage Hurricane, complete genome	138-169	10	0.688
NC_022041_2	2.5\|2474074\|32\|NC_022041\|PILER-CR	2474074-2474105	32	KR080206	Mycobacterium phage ShedlockHolmes, complete genome	138-169	10	0.688
NC_022041_2	2.5\|2474074\|32\|NC_022041\|PILER-CR	2474074-2474105	32	NC_026603	Mycobacterium phage Keshu, complete genome	138-169	10	0.688
NC_022041_2	2.5\|2474074\|32\|NC_022041\|PILER-CR	2474074-2474105	32	NC_020562	Sphingomonas sp. MM-1 plasmid pISP1, complete sequence	101064-101095	11	0.656

1. spacer 3.10|2655759|20|NC_022041|CRT matches to NZ_CP043475 (Mycobacterium grossiae strain DSM 104744 plasmid pGP01, complete sequence) position: , mismatch: 1, identity: 0.95

ccagcgttgcgcggcggtgc	CRISPR spacer
ccagcgttgcgcggcggtgt	Protospacer
*******************.

2. spacer 3.10|2655759|20|NC_022041|CRT matches to NZ_CP043475 (Mycobacterium grossiae strain DSM 104744 plasmid pGP01, complete sequence) position: , mismatch: 1, identity: 0.95

ccagcgttgcgcggcggtgc	CRISPR spacer
ccagcgttgcgcggcggtgt	Protospacer
*******************.

3. spacer 3.10|2655759|20|NC_022041|CRT matches to NZ_CP032156 (Mycobacterium sp. ELW1 plasmid pELW1-1, complete sequence) position: , mismatch: 1, identity: 0.95

ccagcgttgcgcggcggtgc	CRISPR spacer
ccagcgttgcgcggcggtgt	Protospacer
*******************.

4. spacer 2.1|2473830|32|NC_022041|PILER-CR matches to NZ_CP044066 (Cupriavidus pauculus strain FDAARGOS_664 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

tagcccggaccccactgcacgatccgcccgtc	CRISPR spacer
gcgccatcgccccacagctcgatccgcccgtc	Protospacer
  ***   .****** ** *************

5. spacer 2.1|2473830|32|NC_022041|PILER-CR matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 9, identity: 0.719

tagcccggaccccactgcacgatccgcccgtc	CRISPR spacer
cgcggcgtgcccgactgcatgatccgcccgtc	Protospacer
..   ** .*** ******.************

6. spacer 2.5|2474074|32|NC_022041|PILER-CR matches to NZ_CP049358 (Deinococcus wulumuqiensis R12 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.719

agtgcggtcatggtgacggccgagcggtttat	CRISPR spacer
ggctcggtcatggagaaggccgagcggatgtc	Protospacer
.*. ********* ** ********** *  .

7. spacer 2.5|2474074|32|NC_022041|PILER-CR matches to NZ_CP031159 (Deinococcus wulumuqiensis strain NEB 479 plasmid pDrdA, complete sequence) position: , mismatch: 9, identity: 0.719

agtgcggtcatggtgacggccgagcggtttat	CRISPR spacer
ggctcggtcatggagaaggccgagcggatgtc	Protospacer
.*. ********* ** ********** *  .

8. spacer 2.6|2473828|34|NC_022041|CRISPRCasFinder matches to NC_021347 (Rhodococcus phage E3, complete genome) position: , mismatch: 9, identity: 0.735

cgtagcccggaccccactgcacgatccgcccgtc	CRISPR spacer
cgtagcccggacccgcctgcacgacgacctcctt	Protospacer
**************  ********.   *.* *.

9. spacer 2.2|2473891|32|NC_022041|PILER-CR matches to MG592392 (Vibrio phage 1.005.O._10N.286.48.F2, partial genome) position: , mismatch: 10, identity: 0.688

gccgcctttttcagcgcccggcgcatcaccgc	CRISPR spacer
gttcattttttcagcgcccagcgaatcactta	Protospacer
*..  .*************.*** *****.

10. spacer 2.3|2473952|32|NC_022041|PILER-CR matches to CP036421 (Rhodobacter sphaeroides strain HJ plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.688

ctggccgcgtctttcaagatccgttcggtgcg	CRISPR spacer
tgcagatcatctttcaggatccgttcggagcg	Protospacer
.  .   *.*******.*********** ***

11. spacer 2.5|2474074|32|NC_022041|PILER-CR matches to MF373841 (Mycobacterium phage Hurricane, complete genome) position: , mismatch: 10, identity: 0.688

agtgcggtcatggtgacggccgagcggtttat	CRISPR spacer
gccaccgtcaaggagacggccgagcggttctg	Protospacer
. ..* **** ** ***************.

12. spacer 2.5|2474074|32|NC_022041|PILER-CR matches to KR080206 (Mycobacterium phage ShedlockHolmes, complete genome) position: , mismatch: 10, identity: 0.688

agtgcggtcatggtgacggccgagcggtttat	CRISPR spacer
gccaccgtcaaggagacggccgagcggttctg	Protospacer
. ..* **** ** ***************.

13. spacer 2.5|2474074|32|NC_022041|PILER-CR matches to NC_026603 (Mycobacterium phage Keshu, complete genome) position: , mismatch: 10, identity: 0.688

agtgcggtcatggtgacggccgagcggtttat	CRISPR spacer
gccaccgtcaaggagacggccgagcggttctg	Protospacer
. ..* **** ** ***************.

14. spacer 2.5|2474074|32|NC_022041|PILER-CR matches to NC_020562 (Sphingomonas sp. MM-1 plasmid pISP1, complete sequence) position: , mismatch: 11, identity: 0.656

agtgcggtcatggtgacggccgagcggtttat	CRISPR spacer
tatgccgacatggtgacggccgagcttgccgg	Protospacer
 .*** * *****************   ...

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

138102 : 148340

Mycobacterium_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020948948.1\|138102_139458_+	MFS transporter	Q6JIH2	Burkholderia_virus	4.5e-62	34.3
WP_020948949.1\|139481_140447_+	agmatinase	NA	NA	NA	NA
WP_020948950.1\|140925_141147_+	glutaredoxin-like protein NrdH	V5UN81	Mycobacterium_phage	1.3e-14	52.1
WP_020948951.1\|141162_141579_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A217ER62	Bacillus_phage	8.8e-09	33.1
WP_020948952.1\|141560_143687_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	3.4e-213	52.6
WP_020948953.1\|143762_144734_+	class 1b ribonucleoside-diphosphate reductase subunit beta	R4TBI6	Mycobacterium_phage	2.7e-133	72.9
WP_020948954.1\|144817_146449_-	acyl-CoA synthetase	A0A2H4PQU7	Staphylococcus_phage	1.1e-30	26.5
WP_041527029.1\|146783_148340_+	TerC family protein	A0A0R6PEZ3	Moraxella_phage	5.4e-43	47.2

DBSCAN-SWA_2

493657 : 567235

Paracoccus_phage(20.0%)

protease,head,capsid,tRNA,tail,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041527082.1\|493657_494722_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	2.5e-68	44.2
WP_020949291.1\|494850_495507_+	uroporphyrinogen-III synthase	NA	NA	NA	NA
WP_020949292.1\|495628_497170_+	hypothetical protein	NA	NA	NA	NA
WP_020949293.1\|497180_499049_+	HemY domain-containing protein	NA	NA	NA	NA
WP_148292566.1\|499453_499900_+	hypothetical protein	NA	NA	NA	NA
WP_020949294.1\|499968_501069_-	cell division protein ZapE	NA	NA	NA	NA
WP_020949295.1\|501166_502561_+	coniferyl aldehyde dehydrogenase	NA	NA	NA	NA
WP_020949296.1\|502564_503878_-	MFS transporter	NA	NA	NA	NA
WP_020949297.1\|504036_504447_+	hypothetical protein	NA	NA	NA	NA
WP_020949298.1\|504510_505779_-	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_020949299.1\|505821_506757_-	acetyl-CoA carboxylase carboxyltransferase subunit beta	NA	NA	NA	NA
WP_020949300.1\|506846_508274_+	cardiolipin synthase	NA	NA	NA	NA
WP_051201502.1\|508285_508609_+	4a-hydroxytetrahydrobiopterin dehydratase	NA	NA	NA	NA
WP_020949302.1\|508791_509577_+	hypothetical protein	NA	NA	NA	NA
WP_020949303.1\|509609_510002_+	hypothetical protein	NA	NA	NA	NA
WP_020949304.1\|509986_510706_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_020949305.1\|510719_511460_-	competence/damage-inducible protein A	NA	NA	NA	NA
WP_020949306.1\|511575_512382_+	type I methionyl aminopeptidase	NA	NA	NA	NA
WP_020949307.1\|512432_512774_-	hypothetical protein	NA	NA	NA	NA
WP_020949308.1\|512836_513856_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_020949309.1\|514812_518268_-	pyruvate carboxylase	NA	NA	NA	NA
WP_051201610.1\|518348_518780_-	nucleoside deaminase	S4VYT2	Pandoravirus	2.8e-10	46.7
WP_020949312.1\|521225_521402_-	hemin uptake protein HemP	NA	NA	NA	NA
WP_020949313.1\|521568_522621_-	zinc ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_020949314.1\|522702_523233_+	transcriptional repressor	NA	NA	NA	NA
WP_020949315.1\|523229_524066_+	metal ABC transporter ATP-binding protein	M1H3A1	Paramecium_bursaria_Chlorella_virus	6.1e-09	31.2
WP_020949316.1\|524065_524854_+	metal ABC transporter permease	NA	NA	NA	NA
WP_041527084.1\|525058_525289_+	hypothetical protein	NA	NA	NA	NA
WP_020949318.1\|525509_526169_-	YjbF family lipoprotein	NA	NA	NA	NA
WP_020949319.1\|526165_528376_-	YjbH domain-containing protein	NA	NA	NA	NA
WP_020949320.1\|528475_529402_-	hypothetical protein	NA	NA	NA	NA
WP_020949321.1\|529559_530942_-	L-serine ammonia-lyase	NA	NA	NA	NA
WP_051201503.1\|531171_532215_+\|tRNA	tRNA dihydrouridine synthase DusB	NA	NA	NA	NA
WP_020949323.1\|532211_533333_+	two-component sensor histidine kinase	NA	NA	NA	NA
WP_020949324.1\|533343_534792_+	response regulator	NA	NA	NA	NA
WP_162471792.1\|534903_537165_+	HAMP domain-containing protein	W8CYF6	Bacillus_phage	2.5e-09	25.6
WP_020949326.1\|537161_538550_+	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_020949327.1\|538610_539012_+	DoxX family protein	NA	NA	NA	NA
WP_020949328.1\|539036_540413_+	Trk system potassium transporter TrkA	NA	NA	NA	NA
WP_020949329.1\|540427_542053_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_020949330.1\|542160_542394_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_020949331.1\|542394_543702_+	GTPase HflX	NA	NA	NA	NA
WP_020949332.1\|543726_544662_-	carbohydrate kinase	NA	NA	NA	NA
WP_020949334.1\|546015_547194_-	SPFH domain-containing protein	NA	NA	NA	NA
WP_148292650.1\|547284_548328_-	DUF2927 domain-containing protein	NA	NA	NA	NA
WP_020949336.1\|548387_549569_-	toxic anion resistance protein	NA	NA	NA	NA
WP_020949337.1\|549741_551004_+	beta-ketoacyl-ACP synthase II	NA	NA	NA	NA
WP_020949338.1\|551003_552185_+	endolytic transglycosylase MltG	NA	NA	NA	NA
WP_148292567.1\|552537_552903_+	permease	NA	NA	NA	NA
WP_051201504.1\|552853_554194_+	DNA-packaging protein	A0A0K1LMR9	Caulobacter_phage	3.1e-63	38.2
WP_020949341.1\|554337_555522_+\|portal	phage portal protein	W8ECU7	Geobacillus_phage	5.9e-58	37.1
WP_020949342.1\|555525_555759_+	hypothetical protein	NA	NA	NA	NA
WP_020949343.1\|555760_556294_+\|head,protease	HK97 family phage prohead protease	A0A0U2BX10	Paracoccus_phage	9.2e-35	52.6
WP_020949344.1\|556333_557497_+\|capsid	phage major capsid protein	A0A2D1GNH4	Pseudomonas_phage	2.4e-64	41.8
WP_020949345.1\|557626_558241_+	hypothetical protein	NA	NA	NA	NA
WP_020949346.1\|558237_558576_+\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_020949347.1\|558572_558992_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_020949348.1\|559004_559418_+\|tail	phage major tail protein, TP901-1 family	A0A2I7SCY9	Paenibacillus_phage	1.5e-05	29.1
WP_020949349.1\|559417_559735_+	gene transfer agent family protein	NA	NA	NA	NA
WP_020949350.1\|559731_560019_+\|tail	phage tail assembly chaperone	NA	NA	NA	NA
WP_020949351.1\|560032_560698_+\|tail	phage tail tape measure protein	C0LP53	Escherichia_virus	1.4e-11	43.1
WP_020949352.1\|560700_561333_+	DUF2460 domain-containing protein	A0A0B5A2K3	Paracoccus_phage	1.3e-56	48.3
WP_041527541.1\|561332_562163_+	DUF2163 domain-containing protein	A0A0B5A5B8	Paracoccus_phage	9.9e-44	37.3
WP_162471797.1\|562171_562615_+	peptidase	F4YXU4	Roseobacter_phage	7.1e-25	46.9
WP_020949355.1\|562638_566529_+	glycoside hydrolase TIM-barrel-like domain-containing protein	A0A0K1Y6G6	Rhodobacter_phage	4.4e-219	38.4
WP_020949356.1\|566521_567235_+	DUF2793 domain-containing protein	A0A0K1LM04	Rhodobacter_phage	4.7e-18	41.0

DBSCAN-SWA_3

1202902 : 1250601

Brucella_phage(21.05%)

protease,head,transposase,capsid,terminase,tRNA,integrase,tail,portal

attL 1202920:1202936|attR 1213751:1213767

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020949963.1\|1202902_1204072_-\|tRNA	tRNA 2-thiouridine(34) synthase MnmA	NA	NA	NA	NA
1202920:1202936	attL	NA	NA	NA	NA
WP_020949964.1\|1204231_1204507_+	DUF1153 domain-containing protein	NA	NA	NA	NA
WP_084621121.1\|1205183_1206107_-\|integrase	tyrosine-type recombinase/integrase	K7PHK0	Enterobacteria_phage	4.4e-08	32.4
WP_020949967.1\|1206473_1206734_-	hypothetical protein	A0A0K1Y6J3	Rhodobacter_phage	3.7e-05	66.7
WP_020949968.1\|1206807_1207662_-	YfdQ family protein	NA	NA	NA	NA
WP_020949522.1\|1207690_1208017_-	hypothetical protein	I6NMK2	Burkholderia_virus	3.1e-09	34.4
WP_020949523.1\|1208088_1208241_-	hypothetical protein	NA	NA	NA	NA
WP_020952156.1\|1208237_1208672_-	tellurite resistance TerB family protein	A0A1Y0T181	Sinorhizobium_phage	2.1e-29	51.5
WP_041527100.1\|1208840_1209041_-	hypothetical protein	NA	NA	NA	NA
WP_020949525.1\|1209040_1209244_-	hypothetical protein	NA	NA	NA	NA
WP_020949969.1\|1209243_1209492_-	hypothetical protein	NA	NA	NA	NA
WP_020949970.1\|1209488_1209665_-	hypothetical protein	NA	NA	NA	NA
WP_148292580.1\|1210368_1210611_-	hypothetical protein	NA	NA	NA	NA
WP_041527103.1\|1210733_1211003_+	hypothetical protein	A0A1X9HW32	Ruegeria_phage	7.9e-27	65.9
WP_020949972.1\|1211291_1211513_+	hypothetical protein	NA	NA	NA	NA
WP_020949973.1\|1211505_1212045_+	hypothetical protein	A0A218MLE3	uncultured_virus	1.6e-47	50.6
WP_020949974.1\|1212041_1212551_+	hypothetical protein	NA	NA	NA	NA
WP_020949975.1\|1212626_1213256_+	hypothetical protein	NA	NA	NA	NA
WP_020949976.1\|1213494_1214067_+	hypothetical protein	NA	NA	NA	NA
1213751:1213767	attR	NA	NA	NA	NA
WP_020949977.1\|1214063_1214771_+	hypothetical protein	NA	NA	NA	NA
WP_041527164.1\|1214883_1215231_+	HNH endonuclease	Q38456	Bacillus_phage	5.1e-10	37.1
WP_020949979.1\|1215386_1215860_+\|terminase	P27 family phage terminase small subunit	A0A1W6JP17	Morganella_phage	3.9e-05	41.0
WP_020949980.1\|1215846_1217661_+\|terminase	terminase large subunit	A0A0U2C138	Paracoccus_phage	6.5e-141	47.9
WP_020950737.1\|1217660_1218908_+\|portal	phage portal protein	A0A141GEV9	Brucella_phage	1.3e-111	53.7
WP_020949981.1\|1218885_1219731_+\|protease	Clp protease ClpP	A0A141GEW1	Brucella_phage	1.9e-111	71.2
WP_020949982.1\|1219743_1221033_+\|capsid	phage major capsid protein	A0A141GEW2	Brucella_phage	6.7e-148	58.9
WP_020949983.1\|1221102_1221591_+	hypothetical protein	NA	NA	NA	NA
WP_020951333.1\|1221587_1222094_+\|head,tail	phage gp6-like head-tail connector protein	A0A0U2C0V1	Paracoccus_phage	3.7e-25	43.8
WP_020949984.1\|1222090_1222423_+\|head	phage head closure protein	NA	NA	NA	NA
WP_020949985.1\|1222419_1222806_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_041527165.1\|1222828_1223203_-	hypothetical protein	NA	NA	NA	NA
WP_020949986.1\|1223201_1223648_+	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_041527166.1\|1223658_1223847_+	hypothetical protein	NA	NA	NA	NA
WP_020949987.1\|1223839_1224292_+\|tail	phage major tail protein	A0A2D2W2I6	Sinorhizobium_phage	2.1e-11	27.7
WP_020949988.1\|1224291_1224681_+	gene transfer agent family protein	NA	NA	NA	NA
WP_158442340.1\|1224736_1224883_+	hypothetical protein	NA	NA	NA	NA
WP_020949990.1\|1224869_1228298_+	tape measure protein	A0A2D0W9N5	Bordetella_phage	2.3e-46	44.6
WP_020949991.1\|1228297_1228978_+	hypothetical protein	NA	NA	NA	NA
WP_148292581.1\|1228987_1229173_-	hypothetical protein	NA	NA	NA	NA
WP_041527168.1\|1229253_1229820_+	hypothetical protein	A0A141GEX4	Brucella_phage	1.3e-07	27.7
WP_020949993.1\|1229804_1230176_+	hypothetical protein	NA	NA	NA	NA
WP_020949994.1\|1230176_1232228_+	hypothetical protein	A0A1B1IRL4	uncultured_Mediterranean_phage	2.0e-13	23.3
WP_020949995.1\|1232243_1234742_+	hypothetical protein	NA	NA	NA	NA
WP_020949996.1\|1234782_1235079_+	hypothetical protein	NA	NA	NA	NA
WP_020949997.1\|1235145_1235778_+	N-acetylmuramoyl-L-alanine amidase	A0A191VYU0	Roseobacter_phage	8.9e-29	40.2
WP_020949555.1\|1235798_1236008_+	hypothetical protein	NA	NA	NA	NA
WP_020949998.1\|1236358_1237132_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_020949999.1\|1237225_1238128_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_084621033.1\|1238982_1239351_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_084621034.1\|1240208_1240421_+\|transposase	transposase	NA	NA	NA	NA
WP_084621122.1\|1240878_1241736_-	Hint domain-containing protein	NA	NA	NA	NA
WP_020950002.1\|1242598_1243009_-	helix-turn-helix domain-containing protein	K4JNA7	Caulobacter_virus	3.9e-09	44.2
WP_148292582.1\|1243031_1243361_-	hypothetical protein	NA	NA	NA	NA
WP_020950004.1\|1243826_1244165_-	alkylphosphonate utilization protein	NA	NA	NA	NA
WP_020950005.1\|1244500_1244986_-\|protease	serine protease inhibitor ecotin	NA	NA	NA	NA
WP_051201522.1\|1248220_1249429_-	Hint domain-containing protein	NA	NA	NA	NA
WP_148292656.1\|1250235_1250601_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_4

2061463 : 2071668

Brucella_phage(55.56%)

protease,head,capsid,terminase,tail,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_051201547.1\|2061463_2061874_-	gene transfer agent family protein	A0A141GEX0	Brucella_phage	1.1e-14	40.3
WP_020952163.1\|2061873_2062323_-	hypothetical protein	A0A141GEW9	Brucella_phage	8.2e-37	52.7
WP_020950734.1\|2062386_2062593_-	hypothetical protein	NA	NA	NA	NA
WP_020950735.1\|2062585_2063032_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_084621060.1\|2063332_2063710_+	hypothetical protein	NA	NA	NA	NA
WP_020950736.1\|2063745_2064132_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_020949984.1\|2064128_2064461_-\|head	phage head closure protein	NA	NA	NA	NA
WP_020951333.1\|2064457_2064964_-\|head,tail	phage gp6-like head-tail connector protein	A0A0U2C0V1	Paracoccus_phage	3.7e-25	43.8
WP_020949983.1\|2064960_2065449_-	hypothetical protein	NA	NA	NA	NA
WP_020949982.1\|2065518_2066808_-\|capsid	phage major capsid protein	A0A141GEW2	Brucella_phage	6.7e-148	58.9
WP_020949981.1\|2066820_2067666_-\|protease	Clp protease ClpP	A0A141GEW1	Brucella_phage	1.9e-111	71.2
WP_020950737.1\|2067643_2068891_-\|portal	phage portal protein	A0A141GEV9	Brucella_phage	1.3e-111	53.7
WP_020949980.1\|2068890_2070705_-\|terminase	terminase large subunit	A0A0U2C138	Paracoccus_phage	6.5e-141	47.9
WP_020949979.1\|2070691_2071165_-\|terminase	P27 family phage terminase small subunit	A0A1W6JP17	Morganella_phage	3.9e-05	41.0
WP_041527164.1\|2071320_2071668_-	HNH endonuclease	Q38456	Bacillus_phage	5.1e-10	37.1

DBSCAN-SWA_5

2199988 : 2320985

118

Rhizobium_phage(15.15%)

protease,head,transposase,capsid,terminase,tRNA,integrase,tail,portal

attL 2220685:2220701|attR 2257826:2257842

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020950851.1\|2199988_2200438_+\|tRNA	D-tyrosyl-tRNA(Tyr) deacylase	NA	NA	NA	NA
WP_041527829.1\|2200924_2202190_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	1.8e-49	33.9
WP_020950853.1\|2202299_2202875_+	thymidine kinase	G9I9I2	Pseudomonas_phage	3.9e-55	57.4
WP_020950854.1\|2202884_2204264_+	cytochrome b/b6 domain-containing protein	NA	NA	NA	NA
WP_041527286.1\|2204352_2204775_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	1.9e-19	40.5
WP_041527287.1\|2205067_2206918_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	3.8e-80	35.3
WP_020950857.1\|2206984_2207731_+	MipA/OmpV family protein	NA	NA	NA	NA
WP_020950858.1\|2207814_2208174_+	SUF system Fe-S cluster assembly protein	NA	NA	NA	NA
WP_020950859.1\|2208230_2208803_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_041527288.1\|2208845_2209031_-	hypothetical protein	NA	NA	NA	NA
WP_041527830.1\|2209294_2210092_+	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_148292668.1\|2210218_2210608_+	hypothetical protein	NA	NA	NA	NA
WP_020950862.1\|2210802_2211237_+	CoA-binding protein	NA	NA	NA	NA
WP_020950863.1\|2211224_2212244_-	ribose-phosphate pyrophosphokinase	A0A2K9L2G2	Tupanvirus	1.2e-43	36.6
WP_020950864.1\|2212324_2212927_+	2-hydroxychromene-2-carboxylate isomerase	NA	NA	NA	NA
WP_020950865.1\|2212923_2213694_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_041527832.1\|2213729_2214080_-	ATP synthase	NA	NA	NA	NA
WP_020950867.1\|2214187_2214637_-	ATP synthase F1 subunit epsilon	NA	NA	NA	NA
WP_020950868.1\|2214648_2216073_-	F0F1 ATP synthase subunit beta	NA	NA	NA	NA
WP_020950869.1\|2216090_2216969_-	F0F1 ATP synthase subunit gamma	NA	NA	NA	NA
WP_020950870.1\|2216980_2218516_-	F0F1 ATP synthase subunit alpha	NA	NA	NA	NA
WP_041527289.1\|2218515_2219082_-	F0F1 ATP synthase subunit delta	NA	NA	NA	NA
WP_020950872.1\|2219285_2220068_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_020950873.1\|2220163_2220910_+	hydroxyacylglutathione hydrolase	NA	NA	NA	NA
2220685:2220701	attL	NA	NA	NA	NA
WP_020950874.1\|2221114_2223436_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	4.9e-173	45.0
WP_020950875.1\|2223502_2226955_-	transcription-repair coupling factor	NA	NA	NA	NA
WP_041527290.1\|2227003_2227561_-	hypothetical protein	NA	NA	NA	NA
WP_020950877.1\|2227742_2228750_+	porphobilinogen synthase	NA	NA	NA	NA
WP_020950878.1\|2228807_2229380_+	hypothetical protein	NA	NA	NA	NA
WP_041527291.1\|2229452_2230076_-	lytic transglycosylase domain-containing protein	A0A0H3V0Q1	Geobacillus_virus	2.5e-23	56.2
WP_020950880.1\|2230330_2230864_+	single-stranded DNA-binding protein	A0A0U2C0X4	Paracoccus_phage	2.0e-45	73.3
WP_148292561.1\|2231464_2232552_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	9.6e-47	40.2
WP_020950881.1\|2232812_2233478_-	flagellar basal body rod modification protein	NA	NA	NA	NA
WP_020950882.1\|2233492_2235478_-	flagellar hook-length control protein FliK	NA	NA	NA	NA
WP_148292609.1\|2235587_2235818_+	hypothetical protein	NA	NA	NA	NA
WP_020950883.1\|2236286_2237495_+	flagellin	NA	NA	NA	NA
WP_158442355.1\|2237557_2237914_+	flagellar biosynthesis regulator FlhF	NA	NA	NA	NA
WP_020950885.1\|2237919_2238309_+	flagellar biosynthesis repressor FlbT	NA	NA	NA	NA
WP_020950886.1\|2238319_2239111_+	DUF1217 domain-containing protein	NA	NA	NA	NA
WP_020950887.1\|2239672_2240908_-	glycosyltransferase	NA	NA	NA	NA
WP_020950888.1\|2240904_2242500_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.5e-19	33.5
WP_020950889.1\|2242496_2243603_-	ABC transporter permease	NA	NA	NA	NA
WP_020950890.1\|2243602_2244751_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_020950891.1\|2244789_2246634_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_020950892.1\|2246771_2247323_-	cytochrome c family protein	NA	NA	NA	NA
WP_041527292.1\|2247468_2248341_+	prephenate dehydratase	NA	NA	NA	NA
WP_020950894.1\|2248437_2248896_-	SRPBCC family protein	NA	NA	NA	NA
WP_020950895.1\|2249075_2250926_+	bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase	NA	NA	NA	NA
WP_020950896.1\|2251172_2252852_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_020950897.1\|2252936_2254148_+\|portal	phage portal protein	Q6DMU2	Streptococcus_phage	1.6e-42	31.9
WP_158442356.1\|2254137_2254281_+	hypothetical protein	NA	NA	NA	NA
WP_020950898.1\|2254277_2254598_+	gene transfer agent family protein	NA	NA	NA	NA
WP_148292669.1\|2254626_2254857_+	hypothetical protein	NA	NA	NA	NA
WP_020950900.1\|2254853_2256386_+\|capsid	phage major capsid protein	Q3HQT0	Burkholderia_phage	1.1e-35	32.1
WP_020950901.1\|2256389_2256986_+	hypothetical protein	NA	NA	NA	NA
WP_020950902.1\|2256985_2257330_+	HNH endonuclease	A0A286N2R3	Klebsiella_phage	2.9e-10	52.1
WP_020950903.1\|2257322_2258039_+\|tail	tail assembly protein	L7TS77	Rhizobium_phage	3.6e-26	33.7
2257826:2257842	attR	NA	NA	NA	NA
WP_020950904.1\|2258225_2259323_+	DUF262 domain-containing protein	A0A0R6PKN1	Moraxella_phage	3.6e-17	27.9
WP_148292610.1\|2259355_2259949_+	hypothetical protein	NA	NA	NA	NA
WP_020950906.1\|2260088_2260397_+\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_020950907.1\|2260396_2260855_+	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_020950908.1\|2260847_2261270_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_041527294.1\|2261269_2261581_+\|head	phage head closure protein	NA	NA	NA	NA
WP_020950910.1\|2261577_2261979_+\|terminase	P27 family phage terminase small subunit	NA	NA	NA	NA
WP_020950911.1\|2261975_2263628_+\|terminase	phage terminase large subunit	A0A2K5B285	Erysipelothrix_phage	2.6e-56	29.3
WP_020950912.1\|2263646_2266190_+	hypothetical protein	A0A291AUM6	Sinorhizobium_phage	2.6e-47	51.2
WP_020950913.1\|2266636_2267062_+	hypothetical protein	NA	NA	NA	NA
WP_020950914.1\|2267119_2267722_+	hypothetical protein	NA	NA	NA	NA
WP_041527296.1\|2267879_2268101_+	hypothetical protein	NA	NA	NA	NA
WP_020950916.1\|2268589_2269054_+	DUF2380 domain-containing protein	NA	NA	NA	NA
WP_020950917.1\|2269127_2269400_+	hypothetical protein	NA	NA	NA	NA
WP_084621064.1\|2269421_2270942_-	DNA recombination protein RmuC	NA	NA	NA	NA
WP_020950919.1\|2271097_2271646_+	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_020950920.1\|2271661_2272516_-	hypothetical protein	NA	NA	NA	NA
WP_020950921.1\|2272711_2274700_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	4.5e-34	32.6
WP_020950922.1\|2274837_2276790_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	9.3e-93	42.5
WP_041527298.1\|2276831_2277416_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_020950925.1\|2278011_2279181_+	alpha-hydroxy-acid oxidizing protein	NA	NA	NA	NA
WP_041527299.1\|2279184_2280189_-	hypothetical protein	NA	NA	NA	NA
WP_020950927.1\|2280363_2280981_+	50S ribosomal protein L25/general stress protein Ctc	NA	NA	NA	NA
WP_020950928.1\|2281100_2281781_-	O-methyltransferase	W8CYT3	Bacillus_phage	6.4e-33	56.4
WP_020950929.1\|2281881_2282571_-	FkbM family methyltransferase	NA	NA	NA	NA
WP_020950930.1\|2282658_2283999_+\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA
WP_020950931.1\|2284000_2284846_+\|tRNA	tRNA glutamyl-Q(34) synthetase GluQRS	NA	NA	NA	NA
WP_020950932.1\|2284846_2285206_-	phosphoribosyl-AMP cyclohydrolase	NA	NA	NA	NA
WP_041527300.1\|2285265_2285697_+	iron-sulfur cluster assembly scaffold protein	NA	NA	NA	NA
WP_020950934.1\|2286124_2288224_-	ATP-dependent DNA helicase RecG	NA	NA	NA	NA
WP_020950935.1\|2288220_2290491_-	NAD-dependent DNA ligase LigA	A0A1W6DX16	Sphingobium_phage	2.8e-109	36.9
WP_041527301.1\|2291176_2291440_+	hypothetical protein	NA	NA	NA	NA
WP_084621066.1\|2291621_2291810_+	DUF4326 domain-containing protein	A0A222ZJK9	Mycobacterium_phage	6.7e-09	55.6
WP_041527302.1\|2291896_2292823_+	Hint domain-containing protein	NA	NA	NA	NA
WP_084621153.1\|2293286_2294183_+	Hint domain-containing protein	NA	NA	NA	NA
WP_020950940.1\|2294629_2295838_+	Hint domain-containing protein	NA	NA	NA	NA
WP_020950943.1\|2297713_2298409_-	DUF1275 domain-containing protein	NA	NA	NA	NA
WP_084621155.1\|2299169_2300759_+	Hint domain-containing protein	NA	NA	NA	NA
WP_020950945.1\|2301328_2301676_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_020952164.1\|2301774_2301984_-	hypothetical protein	NA	NA	NA	NA
WP_158442357.1\|2302004_2302637_-	N-acetylmuramoyl-L-alanine amidase	A0A191VYM4	Roseobacter_phage	4.4e-28	38.4
WP_020950947.1\|2303190_2303481_-	hypothetical protein	NA	NA	NA	NA
WP_020950948.1\|2303933_2306435_-	hypothetical protein	NA	NA	NA	NA
WP_020950949.1\|2306450_2308502_-	hypothetical protein	A0A1B1IRL4	uncultured_Mediterranean_phage	9.0e-14	22.7
WP_020950950.1\|2308502_2308874_-	hypothetical protein	NA	NA	NA	NA
WP_020950951.1\|2308858_2309425_-	hypothetical protein	A0A141GEX4	Brucella_phage	1.0e-07	27.2
WP_020952165.1\|2309424_2310102_-	hypothetical protein	NA	NA	NA	NA
WP_020950952.1\|2310102_2312973_-	hypothetical protein	A0A223W0P2	Agrobacterium_phage	5.1e-15	48.6
WP_020950953.1\|2312972_2313122_-	hypothetical protein	NA	NA	NA	NA
WP_051201551.1\|2313118_2313529_-	gene transfer agent family protein	A0A141GEX0	Brucella_phage	8.1e-15	39.6
WP_020950955.1\|2313528_2313978_-\|tail	phage major tail protein	A0A141GEW9	Brucella_phage	1.4e-36	51.4
WP_084621067.1\|2314041_2314248_-	hypothetical protein	NA	NA	NA	NA
WP_020950956.1\|2314240_2314675_-	HK97 gp10 family phage protein	B4UTQ0	Rhizobium_phage	2.3e-15	38.5
WP_020950957.1\|2314747_2315134_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_041527848.1\|2315130_2315472_-\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_020952166.1\|2315468_2316008_-	phage DNA packaging protein	NA	NA	NA	NA
WP_148292612.1\|2316010_2316196_-	hypothetical protein	NA	NA	NA	NA
WP_020950959.1\|2316240_2317506_-\|capsid	phage major capsid protein	B4UTP3	Rhizobium_phage	7.0e-158	66.7
WP_041527304.1\|2317598_2318204_-\|head,protease	HK97 family phage prohead protease	B4UTP2	Rhizobium_phage	7.4e-41	54.2
WP_020950960.1\|2318187_2319477_-\|portal	phage portal protein	B4UTP1	Rhizobium_phage	1.9e-134	60.8
WP_158442358.1\|2319473_2320985_-\|terminase	terminase large subunit	A0A141GEV8	Brucella_phage	2.2e-78	36.5

DBSCAN-SWA_6

2467972 : 2532859

Escherichia_phage(13.33%)

protease,transposase,tRNA,integrase,tail

attL 2485788:2485805|attR 2504277:2504294

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020951089.1\|2467972_2470975_-\|tRNA	isoleucine--tRNA ligase	A0A1V0SJ93	Klosneuvirus	2.8e-64	24.4
WP_020951090.1\|2471896_2473258_+	NADP-specific glutamate dehydrogenase	NA	NA	NA	NA
WP_148292619.1\|2474182_2474419_-	type I-E CRISPR-associated endoribonuclease Cas2	NA	NA	NA	NA
WP_020951092.1\|2474421_2475186_+	hypothetical protein	NA	NA	NA	NA
WP_020951093.1\|2475182_2475533_+	hypothetical protein	NA	NA	NA	NA
WP_020951094.1\|2475602_2476460_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	NA	NA	NA	NA
WP_148292561.1\|2477304_2478391_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	9.6e-47	40.2
WP_041527328.1\|2478546_2479008_+	hypothetical protein	NA	NA	NA	NA
WP_020952479.1\|2479306_2480035_-	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	4.8e-34	34.9
WP_020951098.1\|2481779_2482331_+	hypothetical protein	NA	NA	NA	NA
WP_020951099.1\|2482327_2482669_+	hypothetical protein	NA	NA	NA	NA
WP_148292620.1\|2482766_2483186_-	hypothetical protein	NA	NA	NA	NA
WP_041527329.1\|2483486_2483750_-	hypothetical protein	NA	NA	NA	NA
WP_020951100.1\|2484455_2484884_-	VOC family protein	NA	NA	NA	NA
WP_020951101.1\|2485441_2485834_-	hypothetical protein	NA	NA	NA	NA
2485788:2485805	attL	NA	NA	NA	NA
WP_020951103.1\|2486696_2487014_-	hypothetical protein	NA	NA	NA	NA
WP_041527882.1\|2487201_2487483_-	hypothetical protein	NA	NA	NA	NA
WP_020951105.1\|2487686_2488067_-	hypothetical protein	NA	NA	NA	NA
WP_020951106.1\|2488063_2489101_-	S49 family peptidase	A0A291AUM2	Sinorhizobium_phage	8.3e-48	41.5
WP_020951107.1\|2489108_2491565_-\|tail	phage tail tape measure protein	A0A088FV68	Escherichia_phage	2.1e-57	37.7
WP_020951108.1\|2491575_2491914_-\|tail	phage tail assembly protein	NA	NA	NA	NA
WP_020951109.1\|2492269_2492830_-\|tail	phage tail protein	A0A067ZG41	Vibrio_phage	2.6e-08	29.8
WP_041527331.1\|2492985_2493534_-	hypothetical protein	NA	NA	NA	NA
WP_041527332.1\|2493530_2493995_-	hypothetical protein	NA	NA	NA	NA
WP_148292622.1\|2494070_2494532_-	hypothetical protein	NA	NA	NA	NA
WP_148292623.1\|2494531_2495026_-	hypothetical protein	NA	NA	NA	NA
WP_020951112.1\|2495202_2496303_-	AAA family ATPase	NA	NA	NA	NA
WP_084621074.1\|2496313_2496508_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_020951113.1\|2496716_2497949_-\|integrase	site-specific integrase	A0A077KET4	Ralstonia_phage	1.1e-80	44.2
WP_020951114.1\|2498271_2498844_-	polyhydroxyalkanoate synthesis repressor PhaR	NA	NA	NA	NA
WP_020951115.1\|2498999_2499458_-	phasin family protein	NA	NA	NA	NA
WP_020951116.1\|2499645_2502159_-	class I poly(R)-hydroxyalkanoic acid synthase	NA	NA	NA	NA
WP_051201656.1\|2502291_2503629_+	polyhydroxyalkanoate depolymerase	NA	NA	NA	NA
WP_020951118.1\|2503718_2504471_-	alpha/beta hydrolase	NA	NA	NA	NA
2504277:2504294	attR	NA	NA	NA	NA
WP_020951119.1\|2504635_2506585_+\|tRNA	threonine--tRNA ligase	A0A2K9L6B6	Tupanvirus	8.3e-118	36.7
WP_020951120.1\|2506789_2506996_+	cold-shock protein	A0A1W6JNX5	Morganella_phage	1.8e-10	47.5
WP_051201657.1\|2507128_2508595_+	acyl--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	7.9e-28	29.1
WP_020951122.1\|2508591_2509248_+	DsbA family oxidoreductase	NA	NA	NA	NA
WP_020951123.1\|2509392_2511633_+	adenosylcobalamin-dependent ribonucleoside-diphosphate reductase	M4QT32	Loktanella_phage	8.6e-276	63.3
WP_020951124.1\|2511666_2512500_-	hypothetical protein	NA	NA	NA	NA
WP_020951125.1\|2512848_2516586_-	methionine synthase	A0A140XBC7	Dickeya_phage	2.4e-12	54.0
WP_020951126.1\|2516754_2517408_+	lipoyl(octanoyl) transferase LipB	NA	NA	NA	NA
WP_020951127.1\|2517562_2518057_+	cytochrome c550	NA	NA	NA	NA
WP_020951128.1\|2518255_2519932_+	cytochrome c oxidase subunit I	R9VX24	Flavobacterium_phage	1.0e-07	36.8
WP_020951129.1\|2520150_2520645_+	DUF2244 domain-containing protein	NA	NA	NA	NA
WP_020951130.1\|2520807_2521272_-	GatB/YqeY domain-containing protein	NA	NA	NA	NA
WP_020951131.1\|2521456_2522605_+	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	6.3e-41	32.9
WP_084621162.1\|2522784_2524803_+	glycosyltransferase	NA	NA	NA	NA
WP_020951133.1\|2524885_2527732_-	[glutamate--ammonia-ligase] adenylyltransferase	NA	NA	NA	NA
WP_020951134.1\|2528033_2528843_+	arginyltransferase	NA	NA	NA	NA
WP_020951135.1\|2529016_2530771_+	acetolactate synthase 3 large subunit	A0A0P0YLY7	Yellowstone_lake_phycodnavirus	8.5e-53	31.4
WP_020951136.1\|2530843_2531404_+	acetolactate synthase small subunit	NA	NA	NA	NA
WP_020951137.1\|2531426_2531864_-	hypothetical protein	NA	NA	NA	NA
WP_020951138.1\|2532097_2532859_-\|protease	M48 family metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_7

2700782 : 2744064

Brucella_phage(31.58%)

protease,head,capsid,terminase,tRNA,tail,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020951309.1\|2700782_2702894_-\|tRNA	glycine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_020951310.1\|2702893_2703373_-	hypothetical protein	NA	NA	NA	NA
WP_020951311.1\|2703372_2704299_-\|tRNA	glycine--tRNA ligase subunit alpha	NA	NA	NA	NA
WP_020951312.1\|2704384_2705953_+	peptidoglycan-binding protein	NA	NA	NA	NA
WP_020951313.1\|2705876_2707325_-	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_020951314.1\|2707825_2708221_+	hypothetical protein	NA	NA	NA	NA
WP_020951315.1\|2708323_2708530_+	CsbD family protein	NA	NA	NA	NA
WP_041527353.1\|2708574_2709048_+	PRC-barrel domain-containing protein	NA	NA	NA	NA
WP_158442363.1\|2709411_2709567_-	hypothetical protein	NA	NA	NA	NA
WP_020951317.1\|2709937_2710456_-	MgtC/SapB family protein	G3MA03	Bacillus_virus	3.3e-13	34.2
WP_041527354.1\|2711252_2711567_-	hypothetical protein	NA	NA	NA	NA
WP_020951318.1\|2711638_2712841_+	DNA polymerase IV	NA	NA	NA	NA
WP_020951319.1\|2712935_2713667_+	thermonuclease family protein	NA	NA	NA	NA
WP_020951320.1\|2713841_2715101_-	hypothetical protein	NA	NA	NA	NA
WP_020951321.1\|2715340_2715964_-	SOS response-associated peptidase	B7SYF4	Stenotrophomonas_phage	1.8e-18	35.2
WP_020949555.1\|2716215_2716425_-	hypothetical protein	NA	NA	NA	NA
WP_020951322.1\|2716445_2717078_-	N-acetylmuramoyl-L-alanine amidase	Q8W6M2	Sinorhizobium_phage	5.2e-29	45.2
WP_020951323.1\|2717142_2717439_-	hypothetical protein	NA	NA	NA	NA
WP_158442364.1\|2717518_2718103_-	TIGR02646 family protein	NA	NA	NA	NA
WP_158442365.1\|2718216_2719311_-	AAA family ATPase	C7BGE8	Burkholderia_phage	9.4e-10	37.7
WP_041527356.1\|2719424_2721398_-	hypothetical protein	NA	NA	NA	NA
WP_020952171.1\|2721924_2723976_-	hypothetical protein	A0A1B1IRL4	uncultured_Mediterranean_phage	2.2e-12	22.5
WP_020951327.1\|2723976_2724348_-	hypothetical protein	NA	NA	NA	NA
WP_020952154.1\|2724332_2724899_-	hypothetical protein	A0A141GEX4	Brucella_phage	2.7e-08	27.7
WP_020952155.1\|2724898_2725576_-	hypothetical protein	NA	NA	NA	NA
WP_020951328.1\|2725575_2728452_-	hypothetical protein	A0A223W0P2	Agrobacterium_phage	5.2e-15	48.6
WP_020952172.1\|2728451_2728601_-	hypothetical protein	NA	NA	NA	NA
WP_051201569.1\|2728597_2729008_-	gene transfer agent family protein	A0A141GEX0	Brucella_phage	1.1e-14	40.3
WP_020952173.1\|2729007_2729457_-\|tail	phage major tail protein	A0A141GEW9	Brucella_phage	2.2e-37	52.7
WP_020951330.1\|2729520_2729727_-	hypothetical protein	NA	NA	NA	NA
WP_041527358.1\|2729719_2730166_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_020951332.1\|2730508_2730895_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_020949984.1\|2730891_2731224_-\|head	phage head closure protein	NA	NA	NA	NA
WP_020951333.1\|2731220_2731727_-\|head,tail	phage gp6-like head-tail connector protein	A0A0U2C0V1	Paracoccus_phage	3.7e-25	43.8
WP_020949983.1\|2731723_2732212_-	hypothetical protein	NA	NA	NA	NA
WP_020949982.1\|2732281_2733571_-\|capsid	phage major capsid protein	A0A141GEW2	Brucella_phage	6.7e-148	58.9
WP_020949981.1\|2733583_2734429_-\|protease	Clp protease ClpP	A0A141GEW1	Brucella_phage	1.9e-111	71.2
WP_020950737.1\|2734406_2735654_-\|portal	phage portal protein	A0A141GEV9	Brucella_phage	1.3e-111	53.7
WP_020951334.1\|2735653_2737357_-\|terminase	terminase large subunit	I3ULZ6	Rhodobacter_phage	8.7e-188	59.0
WP_020951335.1\|2737343_2737826_-	hypothetical protein	I3ULZ5	Rhodobacter_phage	4.7e-30	48.1
WP_041527360.1\|2737979_2738201_-	hypothetical protein	NA	NA	NA	NA
WP_041527361.1\|2738187_2738526_-	HNH endonuclease	I3ULZ4	Rhodobacter_phage	1.3e-26	55.6
WP_020951337.1\|2738661_2739465_-	hypothetical protein	NA	NA	NA	NA
WP_020951338.1\|2739919_2741764_-	DNA primase	G8DGC0	Emiliania_huxleyi_virus	8.6e-157	50.6
WP_020951339.1\|2741760_2742897_-	DNA primase	I3UM61	Rhodobacter_phage	3.0e-99	53.6
WP_020951340.1\|2742889_2743219_-	hypothetical protein	NA	NA	NA	NA
WP_041527362.1\|2743211_2743511_-	hypothetical protein	NA	NA	NA	NA
WP_041527103.1\|2743794_2744064_-	hypothetical protein	A0A1X9HW32	Ruegeria_phage	7.9e-27	65.9

DBSCAN-SWA_8

3015909 : 3030432

Brucella_phage(40.0%)

protease,head,capsid,terminase,tail,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020951605.1\|3015909_3017961_-	hypothetical protein	H6WBM7	Rhodobacter_phage	6.9e-14	23.7
WP_020950950.1\|3017961_3018333_-	hypothetical protein	NA	NA	NA	NA
WP_020950951.1\|3018317_3018884_-	hypothetical protein	A0A141GEX4	Brucella_phage	1.0e-07	27.2
WP_020951606.1\|3018883_3019561_-	hypothetical protein	NA	NA	NA	NA
WP_020951607.1\|3019561_3022420_-	hypothetical protein	A0A0F6WBM8	Sinorhizobium_phage	2.3e-15	33.2
WP_020950953.1\|3022419_3022569_-	hypothetical protein	NA	NA	NA	NA
WP_051201551.1\|3022565_3022976_-	gene transfer agent family protein	A0A141GEX0	Brucella_phage	8.1e-15	39.6
WP_020950955.1\|3022975_3023425_-\|tail	phage major tail protein	A0A141GEW9	Brucella_phage	1.4e-36	51.4
WP_084621067.1\|3023488_3023695_-	hypothetical protein	NA	NA	NA	NA
WP_020950956.1\|3023687_3024122_-	HK97 gp10 family phage protein	B4UTQ0	Rhizobium_phage	2.3e-15	38.5
WP_020950957.1\|3024194_3024581_-	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_041527848.1\|3024577_3024919_-\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_020951608.1\|3024915_3025455_-	DNA packaging protein	NA	NA	NA	NA
WP_148292612.1\|3025457_3025643_-	hypothetical protein	NA	NA	NA	NA
WP_020950959.1\|3025687_3026953_-\|capsid	phage major capsid protein	B4UTP3	Rhizobium_phage	7.0e-158	66.7
WP_041527304.1\|3027045_3027651_-\|head,protease	HK97 family phage prohead protease	B4UTP2	Rhizobium_phage	7.4e-41	54.2
WP_020950960.1\|3027634_3028924_-\|portal	phage portal protein	B4UTP1	Rhizobium_phage	1.9e-134	60.8
WP_158442358.1\|3028920_3030432_-\|terminase	terminase large subunit	A0A141GEV8	Brucella_phage	2.2e-78	36.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022050

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_022041

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection