CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022222	Staphylococcus aureus subsp. aureus 6850, complete sequence	10 crisprs	cas3,DEDDh,csa3,WYL	2	1	9	2

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022222_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022222_1

701028-701122

Orphan

Consensus_repeat	Method
CCCCTAATTAATAAATTAAAAGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022222_1

>merge|NC_022222|1|701028-701122|CRISPRCasFinder
CCCCTAATTAATAAATTAAAAGGGGACTAAAGGAATACAGTTGGTTGCTAATGCATCAACAGCAAAAGAGCCCCTAATTAATAAATTAAAAGGGG

>NC_022222|1|1|701028-701122|CRISPRCasFinder
CCCCTAATTAATAAATTAAAAGGGG	ACTAAAGGAATACAGTTGGTTGCTAATGCATCAACAGCAAAAGAG
CCCCTAATTAATAAATTAAAAGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022222.1\|WP_020977057.1\|703759_704203_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_022222.1\|WP_000733428.1\|704269_704647_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_020977055.1\|694922_697073_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
NC_022222.1\|WP_000638613.1\|705163_705706_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NC_022222.1\|WP_000081602.1\|693580_694225_+\|Bax-inhibitor-1/YccA-family-protein	unknown	unknown	gnl\|CDD\|223742
NC_022222.1\|WP_014532581.1\|699048_699165_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000152585.1\|702356_702845_+\|DUF456-domain-containing-protein	unknown	unknown	gnl\|CDD\|225395
NC_022222.1\|WP_000842865.1\|702943_703633_-\|DUF1129-family-protein	unknown	unknown	unknown
NC_022222.1\|WP_000731644.1\|692422_693220_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_022222.1\|WP_000545116.1\|704784_705084_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000865622.1\|699309_699954_+\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|225188
NC_022222.1\|WP_042908812.1\|701139_702360_+\|sugar-efflux-transporter	unknown	unknown	gnl\|CDD\|341024
NC_022222.1\|WP_000532966.1\|697767_698484_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|237084
NC_022222.1\|WP_000687412.1\|700069_700936_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NC_022222.1\|WP_001090984.1\|697218_697578_+\|HTH-type-transcriptional-regulator-SarX	unknown	unknown	gnl\|CDD\|130944
NC_022222.1\|WP_000358501.1\|706830_707514_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234750
NC_022222.1\|WP_000120368.1\|690829_691837_+\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|376541
NC_022222.1\|WP_000833488.1\|698483_698957_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|226072
NC_022222.1\|WP_000820892.1\|705801_706368_-\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|224527
NC_022222.1\|WP_000148822.1\|706369_706828_-\|YaiI/YqxD-family-protein	unknown	unknown	gnl\|CDD\|178882

Protein	Function_ID	Function_description	E-value
NC_022222.1\|WP_020977055.1\|694922_697073_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	2.60405e-20
NC_022222.1\|WP_000638613.1\|705163_705706_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.77698e-28
NC_022222.1\|WP_000081602.1\|693580_694225_+\|Bax-inhibitor-1/YccA-family-protein	gnl\|CDD\|223742	COG0670, COG0670, Integral membrane protein, interacts with FtsH [General function prediction only].	1.16188e-32
NC_022222.1\|WP_000731644.1\|692422_693220_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.27934e-40
NC_022222.1\|WP_020977057.1\|703759_704203_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.58097e-13
NC_022222.1\|WP_000152585.1\|702356_702845_+\|DUF456-domain-containing-protein	gnl\|CDD\|225395	COG2839, COG2839, Uncharacterized protein conserved in bacteria [Function unknown].	6.94895e-44
NC_022222.1\|WP_000865622.1\|699309_699954_+\|DUF402-domain-containing-protein	gnl\|CDD\|225188	COG2306, COG2306, Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only].	1.2715e-91
NC_022222.1\|WP_042908812.1\|701139_702360_+\|sugar-efflux-transporter	gnl\|CDD\|341024	cd17471, MFS_Set, Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters. This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.2499e-101
NC_022222.1\|WP_000532966.1\|697767_698484_+\|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|237084	PRK12378, PRK12378, YebC/PmpR family DNA-binding transcriptional regulator.	8.8628e-136
NC_022222.1\|WP_000687412.1\|700069_700936_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	4.04787e-39
NC_022222.1\|WP_001090984.1\|697218_697578_+\|HTH-type-transcriptional-regulator-SarX	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	8.17439e-23
NC_022222.1\|WP_000358501.1\|706830_707514_-\|hypothetical-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	0.000183013
NC_022222.1\|WP_000120368.1\|690829_691837_+\|inorganic-phosphate-transporter	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	5.23541e-104
NC_022222.1\|WP_000833488.1\|698483_698957_+\|cupin-domain-containing-protein	gnl\|CDD\|226072	COG3542, COG3542, Uncharacterized conserved protein [Function unknown].	8.70536e-75
NC_022222.1\|WP_000820892.1\|705801_706368_-\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|224527	COG1611, COG1611, Predicted Rossmann fold nucleotide-binding protein [General function prediction only].	1.24037e-61
NC_022222.1\|WP_000148822.1\|706369_706828_-\|YaiI/YqxD-family-protein	gnl\|CDD\|178882	PRK00124, PRK00124, YaiI/YqxD family protein.	1.00649e-77

>NC_022222.1|WP_000687412.1|700069_700936_+|LysR-family-transcriptional-regulator
MKIEDYRLLITLDETKTLRKAAEILYISQPAVTQRLKAIENAFGVDIFIRTKKQLITTTEGTMIIEHARDMLKRERLFFDKMQAHIGEVNGTISIGCSSLIGQTLLPEVLSLYNAQFPNVEIQVQVGSTEQIKANHRDYHVMITRGNKVMNLANTHLFNDDHYFIFPKNRRDDVTKLPFIEFQADPIYINQIKQWYNDNLEQDYHATITVDQVATCKEMLISGVGVTILPEIMMKNISKEQFEFEKVEIDNEPLIRSTFMSYDPSMLQLPQVDSFVNLMASFVEQPKA
>NC_022222.1|WP_000865622.1|699309_699954_+|DUF402-domain-containing-protein
MKVKYIDKRHWRRLIDREYTEVKVNNNRFKGIIGLVTMKKVRDPLEVTVVGQNIIVADDNYKWLQILPEKKRYSITVMFDNKGNPLEYYFDINIKNITQKGNARTVDLCLDVLALPSGEYELVDEDDLMFALESEQITKKQFHEAYMIAHQIMAELENDFKGFQKKIMYCFNKINAKAQKNHQKPQNKTNFEKSKQIKPKQYNQTKNHQQQKKN
>NC_022222.1|WP_014532581.1|699048_699165_+|hypothetical-protein
MLQLFLMKLTLNDFENDKTILFIILKNHCYEEVCVLSN
>NC_022222.1|WP_000833488.1|698483_698957_+|cupin-domain-containing-protein
MKSAEQWIDELQLESHPEGGFYRETIREVLKDGSRAPFSSIYFLLTDDNISHFHRIDADEVWYYHAGDSLTIHMINPDGEYTTATLGTDIQNGDVLQYVVPKGTIFASSIEISNTYSLVGCMCQPAFEFKQFELFKQSELITQYPHLKSVIEKYALK
>NC_022222.1|WP_000532966.1|697767_698484_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MGRKWNNIKEKKAQKDKNTSRIYAKFGKEIYVAAKSGEPNPESNQALRLVLERAKTYSVPNHIIEKAIDKAKGAGDENFDHLRYEGFGPSGSMLIVDALTNNVNRTASDVRAAFGKNGGNMGVSGSVAYMFDHVATFGIEGKSVDEILETLMEQDVDVNDVIDDNGLTIVYAEPDQFAVVQDALRAAGVEEFKVAEFEMLPQTDIELSEADQVTFEKLIDALEDLEDVQNVFHNVDLK
>NC_022222.1|WP_001090984.1|697218_697578_+|HTH-type-transcriptional-regulator-SarX
MNTEKLETLLGFYKQYKALSEYIDKKYKLSLNDLAVLDLTMKHCKDEKVLMQSFLKTAMDELDLSRTKLLVSIRRLIEKERLSKVRSSKDERKIYIYLNDDDISKFNALFEDVEQFLNI
>NC_022222.1|WP_020977055.1|694922_697073_+|helix-turn-helix-transcriptional-regulator
MAKSCLHILTNNEYATTRCQDGIVLFWPIDGEIELQKFRKSKIIEDDIYIINHLDVFSIKNNKKTIMLYLSSDWFAELGFTFFNYHYTAKLIKSSYNLKCLLLKLTYRYLDNQPLNDADVRKLQDIIKIIAKEASMDKKIAQNQYRYAYYGDLRDELEYIYQNVNQRLTLKSVADKLFVSKSNLSSQFHLLMGMGFKKYIDTLKIGKSIEILLTTDSTISNISEHLGFSSSSTYSKMFKSYVDITPNEYRNLSKYNKCLMLKPEPLVGKMVQEVKEIILNYIEHYKNHLTDVIHIDEDKFETPKLFQTVIQINTYTEMKLVFLEGIFKTLLNKNSQVVFFIMPSILKSKNTMSEEEKFAIIKTIIESDLKIAFNINDIETTYYVEEAFMSVFRQISPNELSNHNNYEVHFVFDLSLMEIRTIYRMILKLHNIMLNVKLGLNITCLFEKPSVFKSLVSQIKRLKFDSLIIDNANLSSPYLMGESDELLLKNILHFKNLKQVINELDIEQEKLIFLNVENHKLINNKERDLSNSAPLIYKTLSALYHNFDGFGLNIFDNHQAFNAMHLYDKNGFKTTLGLILEKFIEYVSKPKYENSYYSIFDIENYYCLVIYDWRVIESETIMSNFEDSQVYINFKNNVLNDKYLIVIETLDENSGNINHLISKELRDKYEWNPSLLSKIDNYLKPAIEIKEHNFSNNSLNINVTFNALYIIKIGKK
>NC_022222.1|WP_000081602.1|693580_694225_+|Bax-inhibitor-1/YccA-family-protein
MSQNTNHSYYHQNQHAQSISKVWLYFMYYWIIFGIGCYLGQFLPLSWRQPLSFGLLIIILATLVFERARRFGLIISHIYAVVIGLLSYATFTTYLQNLGPDIFYKNIALAIFAFIAFGIIGYFFVGDASSIGKYLFVTLITLIIASLIGIFLQNPIFYTIITVVSLLLFLLYTLYDFNRLKRGDYSPREMGFNLFINLLNIIKDILYLANMFRR
>NC_022222.1|WP_000731644.1|692422_693220_-|LysM-peptidoglycan-binding-domain-containing-protein
MKKLAFAITATSGAAAFLTHHDAQASTQHTVQSGESLWSIAQKYNTSVESIKQNNQLDNNLVFPGQVISVGGSDAQNTSNTSPQAGSASSHTVQAGESLNIIASRYGVSVDQLMAANNLRGYLIMPNQTLQIPNGGSGGTTPTATTGSNGNASSFNHQNLYTAGQCTWYVFDRRAQAGSPISTYWSDAKYWAGNAANDGYQVNNTPSVGSIMQSTPGPYGHVAYVERVNGDGSILISEMNYTYGPYNMNYRTIPASEVSSYAFIH
>NC_022222.1|WP_000120368.1|690829_691837_+|inorganic-phosphate-transporter
MSYIIIVTIAVVIFSLIFDFINGFHDTANAVATAVSTRALTPKTAILMAAVMNFIGALTFTGVAGTITKDIVDPFKLENGLVVVLAAILAAIIWNLATWFYGIPSSSSHALIGSIAGAAIASEGSFGVLHYQGFTKIIIVLIVSPIIAFCVGFLMYSIFKVIFKNANLTRANRNFRFFQIFTAALQSFSHGTNDAQKSMGIITLALIVANVQNDGSVEPQLWVKFACATAMGLGTAIGGWKIIKTVGGNIMKIRPANGAAADLSSALTIFVASSLHFPLSTTHVVSSSILGVGASNRAKGVKWSTAQRMIITWVITLPISALLAGLLFYILNLFF
>NC_022222.1|WP_042908812.1|701139_702360_+|sugar-efflux-transporter
MDMFAALLQIKNYKLFVANMFLLGMGIAVTVPYLVLFATKDLGMTTNQYGLLLASAAISQFTVNSIIARFSDTHHFNRKIIIILALLMGALGFSIYFFVDTIWLFILLYAIFQGLFAPAMPQLYASARESINVSSSKDRAQFANTVLRSMFSLGFLFGPFIGAQLIGLKGYAGLFGGTISIILFTLVLQVFFYKDLNIKHPISTQQHVEKIAPNMFKDKTLLLPFIAFILLHIGQWMYTMNMPLFVTDYLKENEQHVGYLASLCAGLEVPFMIILGVLSSRLQTRTLLIYGAIFGSLFYFSIGVFKNFYMMLAGQVFLAIFLAVLLGIGISYFQDILPDFPGYASTLFSNAMVIGQLGGNLLGGAMSHWVGLENVFFVSAASIMLGMILIFFTKNQKITKEDVIST
>NC_022222.1|WP_000152585.1|702356_702845_+|DUF456-domain-containing-protein
MTIILWLLIIAAFMLAFVGLIKPVIPSVLVLWVGFLIYQFGFHNQHLSWAFYVSMALLTILILCADFLANKYFVNRFGGSKFGEYAALIGVVIGCFVLPPFGIIIIPFILVFIVELIQGYSFERAVKVSIGSIVAFLTSSIAQAIIMFIMIVWFFIDALLIN
>NC_022222.1|WP_000842865.1|702943_703633_-|DUF1129-family-protein
MKSTAQLTKENNVKSLRLSNTDREIFENYMTYMRSDFRVNPHDTELIINRILKQLLSAEQHGLLALDFFNHDPKAHAIKELKAMPNETFKNIFKYIYQHIVLLIGIVSFLKGFLGFFMEKSGSNLYFVSFPFSVVVGFFIVFLFIWFSFKTIQLQCFNNSNWIWIFTYLAIILLIVGFFYVFFIPQSLLAFGPYIQVSNWVFIIFSFIVMPIGLRIERNISKKHSHTFL
>NC_022222.1|WP_020977057.1|703759_704203_+|GNAT-family-N-acetyltransferase
MRTLNKDEHNYIKQIANIHETLLSQAESNYKCTKLSIALRYEMICSRLEHTNDKIYIYENEGQLIAFIWGHFSNEKSMVNIELLYVEPQFRKLGIATQLKIALEKWAKTMNAKRISSTIHKSNLPMISLNKDLGYQVSHVKMYKDIN
>NC_022222.1|WP_000733428.1|704269_704647_+|hypothetical-protein
MKKLIISIMAVMLFLTGCGKSEEKASLEKDIDKLEKENKELKDKKEKLKQEKDKLEDKQKDLEKEVKDLKPSKEDNKDDKKDEDKNKEASQDKQSKDQTKSSDKDNHKKPTSTDKDQKANDKHQS
>NC_022222.1|WP_000545116.1|704784_705084_+|hypothetical-protein
MHEQDFRILEGQDITLPELGRELENITGRTIADSTGEIKRVIAHLPNFESDTDTFVATYRLNHQQDFIDATFTALKSDRARLKEVPVHVELISYISKSK
>NC_022222.1|WP_000638613.1|705163_705706_+|GNAT-family-N-acetyltransferase
MIYCETERLILRDWHEDDLLPFQKMNANYDVRKYFPSLLSYRRSELDMRTMDAVIKDYGIGLFAVEDKESHQWIGFIGLNYIPETSDYPFKELPLYEIGWRLLPEFWGKGLATEGAKATLKLAEEHQIYDVYSFTAEANKASQRVMEKIGMTVYDHFELPNLSKYHLLKRQVRYYINLRK
>NC_022222.1|WP_000820892.1|705801_706368_-|TIGR00730-family-Rossman-fold-protein
MKRIAVYCGASKGHDPSYVQKAYDLGKYFAEQGYELVFGAGSIGIMGAIQDGVLDHGGKAIGVMPKMLDEHEITSQRLTELILVDSMHERKNKMAELADAFVMAPGGAGSLEEFFEMYSWAQIGIHEKPIAIYNINGFFNPLQTMIDHMIEEGFIDPKYRALAPLCDTKESLIESILNFKPLGTRSYD
>NC_022222.1|WP_000148822.1|706369_706828_-|YaiI/YqxD-family-protein
MTHIIIDGDACPVVDSIIDLTTETGIFVTIIRSFSHFSNQLYPPHVSTLYVDDGPDAVDYKIVQLSTKDDIVITQDYGLASLLVDKVLIVMHHNGKIYNSKNIQQLLDKRYMNAQIRKQGGRHKGPPPFTKQDQKVFEQSLLKVIHRIKELD
>NC_022222.1|WP_000358501.1|706830_707514_-|hypothetical-protein
MDKKKVIKFMINVLPIVLVPLIVERKRIKQHPDVQKVTDATSKVASKTSAAISNTASDVKEYVGDKKQDFENKRELKKFAREHDPAYIEKKGEKLAKQNRKDADKMNKILQKNIEKRHKEEQKAREKNEIQRIKDMKKSQKYEVKAGLTPNKLDEKTEKKGDKLAEKNRKEIAKMNKKLQKNIEKRHKEEQKRQQEADKARIKSFKKYKDYVAKSASQQNKENNTEA

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Crispr_ID: NC_022222_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022222_2

1116523-1116653

Orphan

Consensus_repeat	Method
CAATGAAAGTTGGGGGGGGCCCCAACACAGAGAAA	PILER-CR

2 spacers

The CRISPR arrays of NC_022222_2

>merge|NC_022222|2|1116523-1116653|PILER-CR
GGGGCCCCAACACAGAGAATTTCGAAAAGAAATTCTACAAACAATGCAAGTTGGGGTGGGCCCCAACATAGAGAAATCGGATCACCAATTCCAACAGACAATGAAAGTTGGGGTGGGGTCCCAACACAGAA

>NC_022222|2|1|1116523-1116653|PILER-CR
GGGGCCCCAACACAGAGAATTTCGAAAAGAAATTCTACAAACAATGCAAGTTG	GGGT
GGGCCCCAACATAGAGAAATCGGATCACCAATTCCAACAGACAATGAAAGTTG	GGGTGGGGTCCCAACACAGAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022222.1\|WP_000659317.1\|1111100_1111688_+\|XTP/dITP-diphosphatase	unknown	unknown	gnl\|CDD\|184835
NC_022222.1\|WP_001039660.1\|1110288_1111089_+\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851
NC_022222.1\|WP_000049479.1\|1111680_1112184_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|223695
NC_022222.1\|WP_000584398.1\|1114431_1114938_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000739527.1\|1122423_1123149_-\|superantigen-like-protein-SSL14	unknown	unknown	gnl\|CDD\|171855
NC_022222.1\|WP_001074342.1\|1124610_1125543_+\|carbamate-kinase	unknown	unknown	gnl\|CDD\|237071
NC_022222.1\|WP_000139712.1\|1109232_1110048_+\|succinate-dehydrogenase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|181515
NC_022222.1\|WP_000231631.1\|1117664_1117898_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000739212.1\|1112672_1112990_+\|fibrinogen-binding-protein	unknown	unknown	gnl\|CDD\|289007
NC_022222.1\|WP_042908669.1\|1120006_1120153_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000793607.1\|1123586_1124588_+\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|235269
NC_022222.1\|WP_000857485.1\|1118374_1119334_-\|alpha-hemolysin	unknown	unknown	gnl\|CDD\|273388
NC_022222.1\|WP_000791583.1\|1115196_1115694_+\|complement-convertase-inhibitor-Efb	unknown	unknown	gnl\|CDD\|289007
NC_022222.1\|WP_078066275.1\|1120109_1120334_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000669534.1\|1115847_1116198_+\|complement-inhibitor-SCIN-family-protein	unknown	unknown	gnl\|CDD\|371594
NC_022222.1\|WP_001038858.1\|1120779_1121496_-\|superantigen-like-protein-SSL12	unknown	unknown	gnl\|CDD\|171995
NC_022222.1\|WP_001032817.1\|1116857_1117043_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_001063565.1\|1121603_1122329_-\|superantigen-like-protein-SSL13	unknown	unknown	gnl\|CDD\|106307
NC_022222.1\|WP_011382246.1\|1112312_1112480_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_020977172.1\|1113359_1113761_-\|formyl-peptide-receptor-like-1-inhibitory-protein	unknown	unknown	gnl\|CDD\|171849

Protein	Function_ID	Function_description	E-value
NC_022222.1\|WP_000659317.1\|1111100_1111688_+\|XTP/dITP-diphosphatase	gnl\|CDD\|184835	PRK14822, PRK14822, XTP/dITP diphosphatase.	1.88157e-114
NC_022222.1\|WP_001039660.1\|1110288_1111089_+\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	8.21475e-134
NC_022222.1\|WP_000049479.1\|1111680_1112184_+\|metallophosphoesterase	gnl\|CDD\|223695	COG0622, COG0622, Predicted phosphoesterase [General function prediction only].	3.1309e-43
NC_022222.1\|WP_001063565.1\|1121603_1122329_-\|superantigen-like-protein-SSL13	gnl\|CDD\|106307	PRK13349, PRK13349, superantigen-like protein; Reviewed.	1.53525e-151
NC_022222.1\|WP_001074342.1\|1124610_1125543_+\|carbamate-kinase	gnl\|CDD\|237071	PRK12353, PRK12353, putative amino acid kinase; Reviewed.	0
NC_022222.1\|WP_000139712.1\|1109232_1110048_+\|succinate-dehydrogenase-iron-sulfur-subunit	gnl\|CDD\|181515	PRK08640, sdhB, succinate dehydrogenase iron-sulfur subunit; Reviewed.	0
NC_022222.1\|WP_000739212.1\|1112672_1112990_+\|fibrinogen-binding-protein	gnl\|CDD\|289007	pfam12199, efb-c, Extracellular fibrinogen binding protein C terminal. This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.	1.17077e-21
NC_022222.1\|WP_000793607.1\|1123586_1124588_+\|ornithine-carbamoyltransferase	gnl\|CDD\|235269	PRK04284, PRK04284, ornithine carbamoyltransferase; Provisional.	0
NC_022222.1\|WP_000857485.1\|1118374_1119334_-\|alpha-hemolysin	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	1.4958e-141
NC_022222.1\|WP_000791583.1\|1115196_1115694_+\|complement-convertase-inhibitor-Efb	gnl\|CDD\|289007	pfam12199, efb-c, Extracellular fibrinogen binding protein C terminal. This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.	1.70884e-26
NC_022222.1\|WP_000739527.1\|1122423_1123149_-\|superantigen-like-protein-SSL14	gnl\|CDD\|171855	PRK13043, PRK13043, superantigen-like protein; Reviewed.	3.05308e-161
NC_022222.1\|WP_001038858.1\|1120779_1121496_-\|superantigen-like-protein-SSL12	gnl\|CDD\|171995	PRK13350, PRK13350, superantigen-like protein; Reviewed.	7.56652e-153
NC_022222.1\|WP_000669534.1\|1115847_1116198_+\|complement-inhibitor-SCIN-family-protein	gnl\|CDD\|371594	pfam11546, CompInhib_SCIN, Staphylococcal complement inhibitor SCIN. SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface. An 18 residue stretch 31-48 is crucial for SCIN activity.	4.49584e-39
NC_022222.1\|WP_020977172.1\|1113359_1113761_-\|formyl-peptide-receptor-like-1-inhibitory-protein	gnl\|CDD\|171849	PRK13033, PRK13033, formyl peptide receptor-like 1 inhibitory protein; Reviewed.	1.12921e-76

>NC_022222.1|WP_000669534.1|1115847_1116198_+|complement-inhibitor-SCIN-family-protein
MKFKKYILTGTLALLLSSTAIATLEGNKAEASSKKDYIIQSEYHDKQIADELRSLLNKSNVYDLAAGSLNRYYKQTIMMNEHRAKAALRSNNFDKMAEAKVALEKIYKEIYEIINR
>NC_022222.1|WP_000791583.1|1115196_1115694_+|complement-convertase-inhibitor-Efb
MKNKLIAKSLLTIAAIGITTTTIASTADASEGYGPREKKPVSINHNIVEYNDGTFKYQSRPKFNSTPKYIKFKHDYNILEFNDGTFEYGARPQFNKPAAKTDVTIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVK
>NC_022222.1|WP_000584398.1|1114431_1114938_+|hypothetical-protein
MIIKILTILLLLCILSYLVTNRKKPFLFLKTLFMGVVFIFIGYISLAISAVIIYGIIQFITIDFGSFFLMGIILILISSIFQLFIVRLLFRKKNVDLTEVVVLEHLIQWFLVYFAIYQAVNEKMDINDINIDNFQSVFFDVSNLNLVILPTLIISWVTIFNYRMRSYK
>NC_022222.1|WP_020977172.1|1113359_1113761_-|formyl-peptide-receptor-like-1-inhibitory-protein
MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWRGLEIAKNLADQAKKDDERIDKLMKESDKNQTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIKVVKNGEIDSIYWD
>NC_022222.1|WP_000739212.1|1112672_1112990_+|fibrinogen-binding-protein
MKKNFIGKSILSIAAISLTVSTFAGESHAQTKVEKYNEYQTNFKKQVNKKVVDAQKAVNLFKRTRTVATHRKAQRAVNLIHFQHSYEKKKLQRQIDLVLKYNTLK
>NC_022222.1|WP_011382246.1|1112312_1112480_+|hypothetical-protein
MKRIVILGNVIVDGPIWLNHVDYLVKSVLLKSIKLRFQEVRKFEILVKIMNRIHI
>NC_022222.1|WP_000049479.1|1111680_1112184_+|metallophosphoesterase
MSKWIIVSDNHTESGVLYQIYEMHPDADVYLHLGDSEFAYDDTELSLFNRVKGNCDFYPEFENEAVAKCNDVKAFYTHGHLYQVNRTRDLLAEKGLELGCLFAFYGHTHVAKYEYINGVHVINPGSISQSRSSMEETYAEVIIDDQTLHGTINFKNRHHETISHTTF
>NC_022222.1|WP_000659317.1|1111100_1111688_+|XTP/dITP-diphosphatase
MKEIVIASNNQGKINDFKVIFPDYHVIGISELIPDFDVEETGSTFEENAILKSEAAAKALNKTVIADDSGLEVFALNGEPGIYSARYAGENKSDEANIEKLLNKLGNTTDRRAQFVCVISMSGPDMETKVFKGTVSGEIADGKYGENGFGYDPIFYVPKLDKTMAQLSKEQKGQISHRRNAINLLQAFLEGDKNV
>NC_022222.1|WP_001039660.1|1110288_1111089_+|glutamate-racemase
MNKPIGVIDSGVGGLTVAKEIMRQLPNETIYYLGDIGRCPYGPRPGEQVKQYTVEIARKLMEFDIKMLVIACNTATAVALEYLQKTLSIPVIGVIEPGARTAIMTTRNQNVLVLGTEGTIKSEAYRTHIKRINPHVEVHGVACPGFVPLVEQMRYSDPTITSIVIHQTLKRWRNSESDTVILGCTHYPLLYKPIYDYFGGKKTVISSGLETAREVSALLTFSNEHASYTEHPDHRFFATGDTTHITNIIKEWLNLSVNVERISVND
>NC_022222.1|WP_000139712.1|1109232_1110048_+|succinate-dehydrogenase-iron-sulfur-subunit
MTEQSVKNTPQHETQSKPKQKTVKLIIKRQDTSDSKPYEETFEIPYRENLNVIACLMEIRRNPVNIKGEKTTPVVWDMNCLEEVCGACSMVINGRARQSCSAIVDQLEQPIRLEPMNTFPVIRDLQVDRSRMFDNLKRMKAWIPIDGTYDLGPGPRMPEKKRQTAYELSKCMTCGVCLEVCPNVTENNKFVGAQAISQVRLFNLHPTGSMTKDERLNALMGTGGLQQCGNSQNCVNACPKGIPLTTSIAAMNRETTFHMFKSFFGSDHEVE
>NC_022222.1|WP_001032817.1|1116857_1117043_-|hypothetical-protein
MNKHINKKATKLLEDYKKVQQRKSEETDRGCLKSVIMLIVLFFLIIFGIVACSTNVNFFFQ
>NC_022222.1|WP_000231631.1|1117664_1117898_-|hypothetical-protein
MVFNDWEINVVYSGEHEVVANEKSLFVIDEFYDVAIAIYYLDGKLKVAHVNYGSDFTIDVANKVFELNIQNPNVDEH
>NC_022222.1|WP_000857485.1|1118374_1119334_-|alpha-hemolysin
MKTRIVSSVTTTLLLGSILMNPVANAADSDINIKTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTN
>NC_022222.1|WP_042908669.1|1120006_1120153_+|hypothetical-protein
MKLFYIVFLIVIWLNIFLGNEIIHTLTVLITTLYIVNSRKGIKNDSVE
>NC_022222.1|WP_078066275.1|1120109_1120334_+|hypothetical-protein
MLIQERGLKMTVLNNIINSLQSLFESESGYKISKNSGVPYQTVQDLRNGKTKLEDARFRTIIKLYSYYVSLKEH
>NC_022222.1|WP_001038858.1|1120779_1121496_-|superantigen-like-protein-SSL12
MNKNITKNIILTTTLLLLGTVLPQNQKPVFSFYSEAKAYSIGQDETNINELIKYYTQPHFSFSNKWLYQYDNGNIYVELKRYSWSAHISLWGAESWGNINQLKDRYVDVFGLKDKDTDQLWWSYRETFTGGVTPAAKPSDKTYNLFVQYKDKLQTIIGAHKIYQGNKPVLTLKEIDFRAREALIKNKILYNENRNKGKLKITGGGNNYTIDLSKRLHSDLANVYVKNPNKITVDVLFD
>NC_022222.1|WP_001063565.1|1121603_1122329_-|superantigen-like-protein-SSL13
MNNNITKKIILSTTLLLLGTASTQFPNTPISSSTEAKAYYINQNETNVNELTKYYSQQHLTFSNKTLWQKDNGTIHATLLQFSWYSHIQVYGPESWGNINQLRNKSVDIFGIKDQETIDSFALSQETFTGGVTPAATSNDKHYKLNVTYKDKAETFTGGFPVYEGNKPVLTLKELDFRIRQTLIKSKKLYNNSYNKGQIKITGADNNYTIDLSKRLPSTDANRYVKKPQNAKIEVILEKSN
>NC_022222.1|WP_000739527.1|1122423_1123149_-|superantigen-like-protein-SSL14
MKKNIMNKLVLSTALLLLGTTSTQLPKTPISFSSEAKAYNISENETNINELIKYYSQPHLSLSNKWLWQKPNGSIHATLQTWVWYSHIQVFGSESWGNINQLRNKYVDIFGTKDEDTVEGYWTYDETFTGGVTPAATSSDKPYRLFLKYSDKQQTIIGGHEFYKGNKPVLTLKELDFRIRQTLIKNKKLYNGEFNKGQIKITADGNNYTIDLSKKLKLTDTNRYVKNPKNAQIEVILEKSN
>NC_022222.1|WP_000793607.1|1123586_1124588_+|ornithine-carbamoyltransferase
MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTRCAFEVAAHDQGANVTYLGPTGSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTYVGDGRNNVANALMQGAAIMGMNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPDEVWKERLELLKPYQVNKEMMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVTDEVFESKASVVFQEAENRMHTIKAVMVATLGEF
>NC_022222.1|WP_001074342.1|1124610_1125543_+|carbamate-kinase
MAKIVVALGGNALGKSPQEQLELVKNTAKSLVGLITKGHEIVISHGNGPQVGSINLGLNYAAEHNQGPAFPFAECGAMSQAYIGYQLQESLQNELHSIGMDKQVVTLVTQVEVDENDPAFNNPSKPIGLFYNKEEAEQIQKEKGFIFVEDAGRGYRRVVPSPQPISIIELESIKTLIKNDTLVIAAGGGGIPVIREQHDGFKGIDAVIDKDKTSALLGANIQCDQLIILTAIDYVYINFNTENQQPLKTTNVDELKRYIDENQFAKGSMLPKIEAAISFIENNPKGSVLITSLNELDAALEGKVGTVIKK

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Crispr_ID: NC_022222_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022222_3

1194339-1194431

Unclear

Consensus_repeat	Method
TAAGAAACAGTAATCAATAAATTGATAACT	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NC_022222_3

>merge|NC_022222|3|1194339-1194431|CRISPRCasFinder
TAAGAAACAGTAATCAATAAATTGATAACTAATAAGCGGAACGCCTGAGCTAAAGCTCATGCATAAGAAACAGTAATCAATAAATTGATAACT

>NC_022222|3|2|1194339-1194431|CRISPRCasFinder
TAAGAAACAGTAATCAATAAATTGATAACT	AATAAGCGGAACGCCTGAGCTAAAGCTCATGCA
TAAGAAACAGTAATCAATAAATTGATAACT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022222.1\|WP_000181404.1\|1204516_1204867_+\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|235418
NC_022222.1\|WP_000164336.1\|1184148_1184793_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NC_022222.1\|WP_000171418.1\|1186453_1186828_+\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|224221
NC_022222.1\|WP_001261987.1\|1203173_1203677_+\|ribosome-maturation-factor-RimM	unknown	unknown	gnl\|CDD\|234650
NC_022222.1\|WP_000007686.1\|1199313_1200564_+\|signal-recognition-particle-docking-protein-FtsY	unknown	unknown	gnl\|CDD\|236686
NC_022222.1\|WP_000687328.1\|1203676_1204414_+\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	unknown	unknown	gnl\|CDD\|234581
NC_022222.1\|WP_000268754.1\|1202710_1202986_+\|30S-ribosomal-protein-S16	unknown	unknown	gnl\|CDD\|223306
NC_022222.1\|WP_000517908.1\|1185822_1186011_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NC_022222.1\|WP_000426914.1\|1194520_1194754_+\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|179197
NC_022222.1\|WP_020977187.1\|1186842_1188489_+\|DAK2-domain-containing-protein	unknown	unknown	gnl\|CDD\|224378
NC_022222.1\|WP_000047352.1\|1192497_1193424_+\|ACP-S-malonyltransferase	unknown	unknown	gnl\|CDD\|223408
NC_022222.1\|WP_000167269.1\|1193416_1194151_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|235500
NC_022222.1\|WP_000262687.1\|1195747_1199314_+\|chromosome-segregation-protein-SMC	unknown	unknown	gnl\|CDD\|224117
NC_022222.1\|WP_014532613.1\|1190941_1191514_+\|transcription-factor-FapR	unknown	unknown	gnl\|CDD\|179847
NC_022222.1\|WP_020977188.1\|1188678_1190739_+\|ATP-dependent-DNA-helicase-RecG	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236794
NC_022222.1\|WP_000043237.1\|1194869_1195601_+\|ribonuclease-III	unknown	unknown	gnl\|CDD\|234633
NC_022222.1\|WP_000531320.1\|1200550_1200883_+\|putative-DNA-binding-protein	unknown	unknown	gnl\|CDD\|234647
NC_022222.1\|WP_000863474.1\|1200908_1202276_+\|signal-recognition-particle-protein	unknown	unknown	gnl\|CDD\|236780
NC_022222.1\|WP_000547905.1\|1184799_1185441_+\|thiamine-diphosphokinase	unknown	unknown	gnl\|CDD\|224480
NC_022222.1\|WP_000239748.1\|1191518_1192505_+\|phosphate-acyltransferase-PlsX	unknown	unknown	gnl\|CDD\|235414

Protein	Function_ID	Function_description	E-value
NC_022222.1\|WP_000181404.1\|1204516_1204867_+\|50S-ribosomal-protein-L19	gnl\|CDD\|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	6.77895e-70
NC_022222.1\|WP_000164336.1\|1184148_1184793_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	6.20812e-114
NC_022222.1\|WP_000171418.1\|1186453_1186828_+\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|224221	COG1302, COG1302, Uncharacterized protein conserved in bacteria [Function unknown].	4.1554e-37
NC_022222.1\|WP_001261987.1\|1203173_1203677_+\|ribosome-maturation-factor-RimM	gnl\|CDD\|234650	PRK00122, rimM, 16S rRNA-processing protein RimM; Provisional.	1.02289e-68
NC_022222.1\|WP_000007686.1\|1199313_1200564_+\|signal-recognition-particle-docking-protein-FtsY	gnl\|CDD\|236686	PRK10416, PRK10416, signal recognition particle-docking protein FtsY; Provisional.	0
NC_022222.1\|WP_000687328.1\|1203676_1204414_+\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	gnl\|CDD\|234581	PRK00026, trmD, tRNA (guanine-N(1)-)-methyltransferase; Reviewed.	2.98496e-164
NC_022222.1\|WP_000268754.1\|1202710_1202986_+\|30S-ribosomal-protein-S16	gnl\|CDD\|223306	COG0228, RpsP, Ribosomal protein S16 [Translation, ribosomal structure and biogenesis].	3.01687e-41
NC_022222.1\|WP_000517908.1\|1185822_1186011_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	1.3072e-18
NC_022222.1\|WP_000426914.1\|1194520_1194754_+\|acyl-carrier-protein	gnl\|CDD\|179197	PRK00982, acpP, acyl carrier protein; Provisional.	5.23888e-31
NC_022222.1\|WP_020977187.1\|1186842_1188489_+\|DAK2-domain-containing-protein	gnl\|CDD\|224378	COG1461, COG1461, Predicted kinase related to dihydroxyacetone kinase [General function prediction only].	0
NC_022222.1\|WP_000047352.1\|1192497_1193424_+\|ACP-S-malonyltransferase	gnl\|CDD\|223408	COG0331, FabD, (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism].	1.21357e-134
NC_022222.1\|WP_000167269.1\|1193416_1194151_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	3.68137e-140
NC_022222.1\|WP_000262687.1\|1195747_1199314_+\|chromosome-segregation-protein-SMC	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	0
NC_022222.1\|WP_014532613.1\|1190941_1191514_+\|transcription-factor-FapR	gnl\|CDD\|179847	PRK04424, PRK04424, transcription factor FapR.	2.55048e-98
NC_022222.1\|WP_020977188.1\|1188678_1190739_+\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NC_022222.1\|WP_000043237.1\|1194869_1195601_+\|ribonuclease-III	gnl\|CDD\|234633	PRK00102, rnc, ribonuclease III; Reviewed.	4.78039e-115
NC_022222.1\|WP_000531320.1\|1200550_1200883_+\|putative-DNA-binding-protein	gnl\|CDD\|234647	PRK00118, PRK00118, putative DNA-binding protein; Validated.	5.84113e-47
NC_022222.1\|WP_000863474.1\|1200908_1202276_+\|signal-recognition-particle-protein	gnl\|CDD\|236780	PRK10867, PRK10867, signal recognition particle protein; Provisional.	0
NC_022222.1\|WP_000547905.1\|1184799_1185441_+\|thiamine-diphosphokinase	gnl\|CDD\|224480	COG1564, THI80, Thiamine pyrophosphokinase [Coenzyme metabolism].	1.16343e-81
NC_022222.1\|WP_000239748.1\|1191518_1192505_+\|phosphate-acyltransferase-PlsX	gnl\|CDD\|235414	PRK05331, PRK05331, phosphate acyltransferase PlsX.	6.1953e-178

>NC_022222.1|WP_000167269.1|1193416_1194151_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQKATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNAVAPGFIVSDMTDALSDELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVNGGMYM
>NC_022222.1|WP_000047352.1|1192497_1193424_+|ACP-S-malonyltransferase
MSKTAIIFPGQGAQKVGMAQDLYNNNDQATEILTSAANTLDFDILETMFTDEDGKLGETENTQPALLTHSSALLAALKNLNPDFTMGHSLGEYSSLVAADVLSFEDAVKIVRKRGQLMAQAFPTGVGSMAAVLGLDFDKVDEICKSLSSDDKIIEPANINCPGQIVVSGHKALIDELVEKGKSLGAKRVMPLAVSGPFHSSLMKVIEEDFSSYINQFEWRDAKFPVVQNVNAQGETDKEVIKSNMVKQLYSPVQFINSTEWLIDQGVDHFIEIGPGKVLSGLIKKINRDVKLTSIQTLEDVKGWNEND
>NC_022222.1|WP_000239748.1|1191518_1192505_+|phosphate-acyltransferase-PlsX
MVKLAIDMMGGDNAPDIVLEAVQKAVEDFKDLEIILFGDEKKYNLNHERIEFRHCSEKIEMEDEPVRAIKRKKDSSMVKMAEAVKSGEADGCVSAGNTGALMSAGLFIVGRIKGVARPALVVTLPTIDGKGFVFLDVGANADAKPEHLLQYAQLGDIYAQKIRGIDNPKISLLNIGTEPAKGNSLTKKSYELLNQDHSLNFVGNIEAKTLMDGDTDVVVTDGYTGNMVLKNLEGTAKSIGKMLKDTIMSSTKNKLAGAILKKDLAEFAKKMDYSEYGGSVLLGLEGTVVKAHGSSNAKAFYSAIRQAKIAGEQNIVQTMKETVGESNE
>NC_022222.1|WP_014532613.1|1190941_1191514_+|transcription-factor-FapR
MRGETLKLKKDKRREAIRQQIDSNPFITDHELSDLFQVSIQTIRLDRTYLNIPELRKRIKLVAEKNYDQISSIEEQEFIGDLIQVNPNVKAQSILDITSDSVFYKTGIARGHVLFAQANSLCVALIKQPTVLTHESSIQFIEKVKLNDTVRAEARVVNQTAKHYYVEVKSYVKHTLVFKGNFKMFYDKRG
>NC_022222.1|WP_020977188.1|1188678_1190739_+|ATP-dependent-DNA-helicase-RecG
MAKVNLIESPYSLLQLKGIGPKKIEVLQQLNIHTVEDLVLYLPTRYEDNTVIDLNQAEDQSNVTIEGQVYTAPVVAFFGRNKSKLTVHLMVNNIAVKCIFFNQPYLKKKIELNQTITVKGKWNRVKQEITGNRVFFNSQGTQTQENADVQLEPVYRIKEGIKQKQIRDQIRQALNDVTIHEWLTDELREKYKLETLDFTLNTLHHPKSKEDLLRARRTYAFTELFLFELRMQWLNRLEKSSDEAIEIDYDLDQVKSFIDCLPFELTEAQKSSVNEIFRDLKAPIRMHRLLQGDVGSGKTVVAAICMYALKTAGYQSALMVPTEILAEQHAESLIALFGDSMNVALLTGSVKGKKRKILLEQLENGTIDCLIGTHALIQDDVIFHNVGLVITDEQHRFGVNQRQLLREKGAMTNVLFMTATPIPRTLAISVFGEMDVSSIKQLPKGRKPIITTWAKHEQYDKVLMQMTSELKKGRQAYVICPLIESSEHLEDVQNVVALYESLQQYYGVSRVGLLHGKLSADEKDEVMQKFSNHEIDVLVSTTVVEVGVNVPNATFMMIYDADRFGLSTLHQLRGRVGRSDQQSYCVLIASPKTETGIERMTIMTQTTDGFELSERDLEMRGPGDFFGVKQSGLPDFLVANLVEDYRMLEVARDEAAELIQSGVFFENTYQHLRHFVEENLLHRSFD
>NC_022222.1|WP_020977187.1|1186842_1188489_+|DAK2-domain-containing-protein
MISKINGKLFADMIIQGAQNLSNNADLVDSLNVYPVPDGDTGTNMNLTMTSGREEVENNLSKNIGELGKTFSKGLLMGARGNSGVILSQLFRGFCKNIESESEINSKLLAESFQAGVETAYKAVMKPVEGTILTVAKDAAQAAVEKANNTEDCIELMEYIIVKANESLENTPNLLAVLKEVGVVDSGGKGLLCVYEGFLKALKGEKVEAKVAKLDKDEFVHDEHDFHGVINTEDIIYGYCTEMMVRFGKNKKAFDEQEFRQDMSQFGDSLLVINDEEIVKVHVHTEYPGKVFNYGQQYGELIKLKVENMREQHREVIRKEQHTAKPKMETVETAIITISMGEGISEIFKSMGATHIISGGQTMNPSTEDIVKVIEQSKCKRAIILPNNKNILMASEQAASIVDAEAVVIPTKSIPQGISALFQYDVDATLEENKAQMADSVNNVKSGSLTYAVRDTKIDGVEIKKDAFMGLIEDKIVSSHSDQLTTVTELLNEMLAEDSEILTVIIGQDAEQAVTDNMINWIEEQYPDVEVEVHEGGQPIYQYFFSVE
>NC_022222.1|WP_000171418.1|1186453_1186828_+|Asp23/Gls24-family-envelope-stress-response-protein
MTLEISNDYGKIDISNEVIASVVGGKAVECYGIVGMASRQQVRDGIAEILGHENYAKGIKVTENNGVVDIDMYIIVSYGVKISEVANNVQSTVKYTLEKSLNVSVNSINIYVQGVRVNNTGKKA
>NC_022222.1|WP_000517908.1|1185822_1186011_-|50S-ribosomal-protein-L28
MGKQCFVTGRKASTGNRRSHALNSTKRRWNANLQKVRILVDGKPKKVWVSARALKSGKVTRV
>NC_022222.1|WP_000547905.1|1184799_1185441_+|thiamine-diphosphokinase
MHINLLCSDRHLPQDIWAKSNEGKWGGVDRGALILLKHQIIPFFSVGDFDSVSKEERQLLTEQLQIKPVQAEKADTDLALAVDKAVALGFDSITIYGATGGRLDHFFGAIQLLLKKAYYKHDVHIEVIDQQNKIELLPKGQHTVEKDKSYPYISFIPMTDDVELSLAGFKYNLARQMLNIGSTLTISNEIESLQAKVTVHDGLILQIRSTDLN
>NC_022222.1|WP_000164336.1|1184148_1184793_+|ribulose-phosphate-3-epimerase
MTKLYPSLLSVDFLDLQHELKRLEEAGVDGVHFDVMDGQFVPNISIGLPILDAVRKGTTLPIDVHLMIENPEKYIASFAEHGADMISIHVESTPHIHRAIQMIKHLDKKAGVVINPGTPISQIEPILDIVDYVLVMTVNPGFGGQSFIDQCVEKMAGLNAIKMERQLNFDIEVDGGVNTDTAKVCVENGATMLVTGSFFFKQEDYKKVTQALKG
>NC_022222.1|WP_000426914.1|1194520_1194754_+|acyl-carrier-protein
MENFDKVKDIIVDRLGVDADKVTEDASFKDDLGADSLDIAELVMELEDEFGTEIPDEEAEKINTVGDAVKFINSLEK
>NC_022222.1|WP_000043237.1|1194869_1195601_+|ribonuclease-III
MSKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLKQIK
>NC_022222.1|WP_000262687.1|1195747_1199314_+|chromosome-segregation-protein-SMC
MVYLKSIDAIGFKSFADQTNVQFDKGVTAIVGPNGSGKSNITDAIKWVLGEQSAKSLRGSKMEDIIFSGAEHRKAQNYAEVQLRLDNHSKKLSVDENEVIVTRRLYRSGESEYYINNDRARLKDIADLFLDSGLGKEAYSIISQGRVDEILNAKPIDRRQIIEESAGVLKYKKRKAESLNKLDQTEDNLTRVEDILYDLEGRVEPLKEEAAIAKEYKTLSHQMKHSDIVVTVHDIDQYTNDNRQLDQRLNDLQGQQANKEADKQRLSQQIQQYKGKRHQLDNDVESLNYQLVKATEAFEKYTGQLNVLEERKKNQSETNARYEEEQENLIELLENISNEISEAQDTYKSLKSKQKELNAVIRELEEQLYVSDEAHDEKLEEIKNEYYTLMSEQSDVNNDIRFLKHTIEENEAKKSRLDSRLVEVFEQLKDIQGQIKTTKKEYQQTNKELSAVDKEIKNIEKDLTDTKKAQNEYEEKLYQAYRYTEKMKTRIDSLATQEEEYTYFFNGVKHILKAKNKELKGIHGAVAEIIDVPSKLTQAIETALGASLQHVIVDSEKDGRQAIQFLKERNLGRATFLPLNVIQSRVVATDIKSIAKEANGFISIASEAVKVAPEYQNIIGNLLGNTIIVDHLKHANELARAIKYRTRIVTLEGDIVNPGGSMTGGGARKSKSILSQKDELTTMRHQLEDYLRQTESFEQQFKELKIKSDQLSELYFEKSQKHNTLKEQVHHFEMELDRLTTQETQIKNDHEEFEFEKNDGYTSDKSRQTLSEKETHLESIKASLKRLEDEIERYTKLSKEGKESVTKTQQTLHQKQSDLAVVKERIKTQQQTIDRLNNQSQQTKHQLNDVKEKIAFFNSDEVMGEQAFQNIKDQINGQQETRTRLSDELDKLKQQRIELNEQIDAQEATLQVCHQDILAIENHYQDIKAEQSKLDVLIHHAIDHLNDEYQLTVERAKSEYTSDESIDALRKKVKLMKMSIDELGPVNLNAIEQFEELNERYTFLSEQRTDLRKAKETLEQIISEMDQEVTERFKETFHAIQGHFTAVFKQLFGGGDAELQLTEADYLTAGIDIVVQPPGKKLQHLSLLSGGERALTAIALLFAILKVRSAPFVILDEVEAALDEANVIRYAKYLNELSDETQFIVITHRKGTMEFADRLYGVTMQESGVTKLVSVNLNTIDDVLKEEQ
>NC_022222.1|WP_000007686.1|1199313_1200564_+|signal-recognition-particle-docking-protein-FtsY
MSFFKRLKDKFATNKENEEVKSLTEEQGQDKLEDTHSEGSTQDVNDLAENAEVKKKPRKLSEADFDDDGLISIEDFEEIEAQKMGAKFKAGLEKSRQNFQEQLNNLIARYRKVDEDFFEALEEMLITADVGFNTVMTLTEELRMEAQRRNIQDTEDLREVIVEKIVEIYHQEDDNSEAMNLEDGRLNVILMVGVNGVGKTTTIGKLAYRYKMEGKKVMLAAGDTFRAGAIDQLKVWGERVGVDVISQSEGSDPAAVMYDAINAAKNKGVDILICDTAGRLQNKTNLMQELEKVKRVINRAVPDAPHEALLCLDATTGQNALSQARNFKEVTNVTGIVLTKLDGTAKGGIVLAIRNELHIPVKYVGLGEQLDDLQPFNPESYVYGLFADMIEQNEEITTVENDQIVTEEKDDNHGAK
>NC_022222.1|WP_000531320.1|1200550_1200883_+|putative-DNA-binding-protein
MGQNDLVKTLRMNYLFDFYQSLLTNKQRNYLELFYLEDYSLSEIADTFNVSRQAVYDNIRRTGDLVEDYEKKLELYQKFEQRREIYDEMKQHLSNPEQIQRYIQQLEDLE
>NC_022222.1|WP_000863474.1|1200908_1202276_+|signal-recognition-particle-protein
MAFEGLSERLQATMQKMRGKGKLTEADIKIMMREVRLALLEADVNFKVVKEFIKTVSERALGSDVMQSLTPGQQVIKIVQDELTKLMGGENTSINMSNKPPTVVMMVGLQGAGKTTTAGKLALLMRKKYNKKPMLVAADIYRPAAINQLQTVGKQIDIPVYSEGDQVKPQQIVTNALKHAKEEHLDFVIIDTAGRLHIDEALMNELKEVKDIAKPNEIMLVVDSMTGQDAVNVAESFDDQLDVTGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLELFHPERMASRILGMGDVLSLIEKAQQDVDQEKAKDLEKKMRESSFTLDDFLEQLDQVKNLGPLDDIMKMIPGMNKMKGLDKLNMSEKQIDHIKAIIQSMTPAERNNPDTLNVSRKKRIAKGSGRSLQEVNRLMKQFNDMKKMMKQFTGGGKGKKGKRNQMQNMLKGMNLPF
>NC_022222.1|WP_000268754.1|1202710_1202986_+|30S-ribosomal-protein-S16
MAVKIRLTRLGSKRNPFYRIVVADARSPRDGRIIEQIGTYNPTSANAPEIKVDEALALKWLNDGAKPTDTVHNILSKEGIMKKFDEQKKAK
>NC_022222.1|WP_001261987.1|1203173_1203677_+|ribosome-maturation-factor-RimM
MRVEVGQIVNTHGIKGEIKVKSNSDFTDVRFQPGQVLTVVHNNNDLEYTVKSHRVHKGLHMLTFEGINNINDIEHLKGSSIYQERDHEDIVLEENEFYYSDIIGCTVFDDQETPIGRVINIFETGANDVWVIKGSKEYLIPYIADVVKEVDVENKKIIITPMEGLLD
>NC_022222.1|WP_000687328.1|1203676_1204414_+|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD
MKIDYLTLFPEMFDGVLNHSIMKRAQENNKLQINTVNFRDYAINKHNQVDDYPYGGGQGMVLKPEPVFNAMEDLDVTEQTRVILMCPQGEPFSHQKAVELSKADHIVFICGHYEGYDERIRTHLVTDEISMGDYVLTGGELPAMTMTDAIVRLIPGVLGNEQSHQDDSFSDGLLEFPQYTRPREFKGLTVPDVLLSGNHANIDAWRHEQKLIRTYNKRPDLIEKYPLTNADKQILERYKIGLKKG
>NC_022222.1|WP_000181404.1|1204516_1204867_+|50S-ribosomal-protein-L19
MTNHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIKRRGGGVSETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYYLRSLRGKAARIQEIR

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Crispr_ID: NC_022222_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022222_4

1402254-1402333

Orphan

Consensus_repeat	Method
CCAACTTGCACATTATTGTAAGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022222_4

>merge|NC_022222|4|1402254-1402333|CRISPRCasFinder
CCAACTTGCACATTATTGTAAGCTGGCTTTCCGCAGCTACTATGTTGGGGACCCGCCAACTTGCACTTTATTGTAAGCTG

>NC_022222|4|3|1402254-1402333|CRISPRCasFinder
CCAACTTGCACATTATTGTAAGCTG	GCTTTCCGCAGCTACTATGTTGGGGACCCG
CCAACTTGCACTTTATTGTAAGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022222.1\|WP_020977258.1\|1392762_1393554_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NC_022222.1\|WP_000334509.1\|1393966_1394776_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319934
NC_022222.1\|WP_020977260.1\|1405499_1406990_-\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|223864
NC_022222.1\|WP_001115452.1\|1395355_1396624_-\|dihydrolipoyllysine-residue-succinyltransferase	unknown	unknown	gnl\|CDD\|235571
NC_022222.1\|WP_042908694.1\|1408958_1409798_-\|fatty-acid-kinase-FakB2	unknown	unknown	gnl\|CDD\|273257
NC_022222.1\|WP_000180678.1\|1396637_1399436_-\|2-oxoglutarate-dehydrogenase-E1-component	unknown	unknown	gnl\|CDD\|236499
NC_022222.1\|WP_000620194.1\|1404590_1405100_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_022222.1\|WP_000175746.1\|1409812_1410292_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NC_022222.1\|WP_001039275.1\|1389294_1390638_-\|branched-chain-amino-acid-transport-system-II-carrier-protein	unknown	unknown	gnl\|CDD\|224039
NC_022222.1\|WP_000801007.1\|1407181_1407403_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226885
NC_022222.1\|WP_000160908.1\|1403508_1404579_-\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|171505
NC_022222.1\|WP_000473654.1\|1407402_1407903_-\|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|225101
NC_022222.1\|WP_000192137.1\|1401076_1401736_-\|response-regulator-transcription-factor-ArlR	unknown	unknown	gnl\|CDD\|223816
NC_022222.1\|WP_000913315.1\|1407914_1408343_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|234692
NC_022222.1\|WP_000159902.1\|1408335_1408869_-\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|237269
NC_022222.1\|WP_020977259.1\|1399724_1401080_-\|sensor-histidine-kinase-ArlS	unknown	unknown	gnl\|CDD\|223715
NC_022222.1\|WP_000902174.1\|1393734_1393938_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_001283670.1\|1390862_1392749_-\|nitric-oxide-reductase-activation-protein-NorD	unknown	unknown	gnl\|CDD\|226921
NC_022222.1\|WP_020977257.1\|1388085_1389222_+\|toxic-anion-resistance-protein	unknown	unknown	gnl\|CDD\|377557
NC_022222.1\|WP_000084773.1\|1402877_1403492_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486

Protein	Function_ID	Function_description	E-value
NC_022222.1\|WP_020977258.1\|1392762_1393554_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	5.86922e-45
NC_022222.1\|WP_000334509.1\|1393966_1394776_-\|hypothetical-protein	gnl\|CDD\|319934	cd08346, PcpA_N_like, N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins. The N-terminal domain of Sphingobium chlorophenolicum (formerly Sphingomonas chlorophenolica) 2,6-dichloro-p-hydroquinone1,2-dioxygenase (PcpA), and similar proteins. PcpA is a key enzyme in the pentachlorophenol (PCP) degradation pathway, catalyzing the conversion of 2,6-dichloro-p-hydroquinone to 2-chloromaleylacetate. This domain belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	8.74417e-08
NC_022222.1\|WP_020977260.1\|1405499_1406990_-\|S41-family-peptidase	gnl\|CDD\|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	3.69518e-123
NC_022222.1\|WP_001115452.1\|1395355_1396624_-\|dihydrolipoyllysine-residue-succinyltransferase	gnl\|CDD\|235571	PRK05704, PRK05704, 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase.	0
NC_022222.1\|WP_042908694.1\|1408958_1409798_-\|fatty-acid-kinase-FakB2	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	1.2502e-118
NC_022222.1\|WP_000180678.1\|1396637_1399436_-\|2-oxoglutarate-dehydrogenase-E1-component	gnl\|CDD\|236499	PRK09404, sucA, 2-oxoglutarate dehydrogenase E1 component; Reviewed.	0
NC_022222.1\|WP_000620194.1\|1404590_1405100_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.78214e-09
NC_022222.1\|WP_000175746.1\|1409812_1410292_-\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	8.71869e-81
NC_022222.1\|WP_000160908.1\|1403508_1404579_-\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	gnl\|CDD\|171505	PRK12446, PRK12446, undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed.	3.82367e-132
NC_022222.1\|WP_000159902.1\|1408335_1408869_-\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|237269	PRK13014, PRK13014, methionine sulfoxide reductase A; Provisional.	4.15064e-107
NC_022222.1\|WP_000473654.1\|1407402_1407903_-\|PTS-glucose-transporter-subunit-IIA	gnl\|CDD\|225101	COG2190, NagE, Phosphotransferase system IIA components [Carbohydrate transport and metabolism].	9.03019e-68
NC_022222.1\|WP_000192137.1\|1401076_1401736_-\|response-regulator-transcription-factor-ArlR	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.42624e-89
NC_022222.1\|WP_000913315.1\|1407914_1408343_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|234692	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB.	9.76591e-81
NC_022222.1\|WP_020977259.1\|1399724_1401080_-\|sensor-histidine-kinase-ArlS	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.86333e-49
NC_022222.1\|WP_000801007.1\|1407181_1407403_-\|hypothetical-protein	gnl\|CDD\|226885	COG4479, COG4479, Uncharacterized protein conserved in bacteria [Function unknown].	1.53726e-28
NC_022222.1\|WP_001039275.1\|1389294_1390638_-\|branched-chain-amino-acid-transport-system-II-carrier-protein	gnl\|CDD\|224039	COG1114, BrnQ, Branched-chain amino acid permeases [Amino acid transport and metabolism].	1.47543e-160
NC_022222.1\|WP_001283670.1\|1390862_1392749_-\|nitric-oxide-reductase-activation-protein-NorD	gnl\|CDD\|226921	COG4548, NorD, Nitric oxide reductase activation protein [Inorganic ion transport and metabolism].	0
NC_022222.1\|WP_020977257.1\|1388085_1389222_+\|toxic-anion-resistance-protein	gnl\|CDD\|377557	pfam05816, TelA, Toxic anion resistance protein (TelA). This family consists of several prokaryotic TelA like proteins. TelA and KlA are associated with tellurite resistance and plasmid fertility inhibition.	6.28665e-131
NC_022222.1\|WP_000084773.1\|1402877_1403492_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	6.60547e-49

>NC_022222.1|WP_000192137.1|1401076_1401736_-|response-regulator-transcription-factor-ArlR
MTQILIVEDEQNLARFLELELTHENYNVDTEYDGQDGLDKALSHYYDLIILDLMLPSINGLEICRKIRQQQSTPIIIITAKSDTYDKVAGLDYGADDYIVKPFDIEELLARIRAILRRQPQKDIIDVNGITIDKNAFKVTVNGAEIELTKTEYDLLYLLAENKNHVMQREQILNHVWGYNSEVETNVVDVYIRYLRNKLKPYDRDKMIETVRGVGYVIR
>NC_022222.1|WP_020977259.1|1399724_1401080_-|sensor-histidine-kinase-ArlS
MTKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKPVKDISALDLNASLGNFQEIIIYDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGIDYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALAFGVIATIITATISYVFSTQITKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDASHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMDRIIKLVEELLELTKGDVNDISSEAQTVHINDEIRSRIHSLKQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAIKYDVKNKKIKVKTRLKNKQKIIEITDNGIGIPEEDQDFIFDRFYRVDKSRSRSQGGNGLGLSIAQKIIQLNGGSIKIKSEINKGTTFKIIF
>NC_022222.1|WP_000180678.1|1396637_1399436_-|2-oxoglutarate-dehydrogenase-E1-component
MTNERKEVSEAPVNFGANLGLMLDLYDDFLQDPSSVPEDLQVLFSTIKNDDSIVPALKSTSSQNSDGTIKRVMRLIDNIRQYGHLKADIYPVNPPKRKHVPKLEIEDFDLDQQTLEGISAGIVSDHFADIYDNAYEAILRMEKRYKGPIAFEYTHINNNTERGWLKRRIETPYKVTLNNNEKRALFKQLAYVEGFEKYLHKNFVGAKRFSIEGVDALVPMLQRTITIAAKEGIKNIQIGMAHRGRLNVLTHVLEKPYEMMISEFMHTDPMKFLPEDGSLQLTAGWTGDVKYHLGGIKTTDSYGTMQRIALANNPSHLEIVAPVVEGRTRAAQDDTQRAGAPTTDHHKAMPIIIHGDAAYPGQGINFETMNLGNLKGYSTGGSLHIITNNRIGFTTEPIDARSTTYSTDVAKGYDVPIFHVNADDVEATIEAIDIAMEFRKEFHKDVVIDLVGYRRFGHNEMDEPSITNPVPYQNIRKHDSVEYVFGKKLVNEGVISEDEMNSFIEQVQKELRQAHDKINKADKMDNPDMEKPADLALPLQADEQSFTFDHLKEINDALLTYPDGFNILKKLNKVLEKRHEPFNKEDGLVDWAQAEQLAFATILQDGTPIRLTGQDSERGTFSHRHAVLHDEQTGETYTPLHHVPDQKATFDIHNSPLSEAAVVGFEYGYNVENKKSFNIWEAQYGDFANMSQMIFDNFLFSSRSKWGERSGLTLFLPHAYEGQGPEHSSARLERFLQLAAENNCTVVNLSSSSNYFHLLRAQAASLDSEQMRPLVVMSPKSLLRNKTVAKPIDEFTSGGFEPILTESYQADKVTKVILATGKMFIDLKEALAKNPDESVLLVAIERLYPFPEEEIEALLAQLPNLEEVSWVQEEPKNQGAWLYVYPYVKVLVADKYDLSYHGRIQRAAPAEGDGEIHKLVQNKIIENALKNN
>NC_022222.1|WP_001115452.1|1395355_1396624_-|dihydrolipoyllysine-residue-succinyltransferase
MPEVKVPELAESITEGTIAEWLKNVGDSVEKGEAILELETDKVNVEVVSEEAGVLSEQLASEGDTVEVGQAIAVIGEGSGNASKENSNDNTPQQNEETNNKKEETTNKSADKAEVNQTTDDNQQRVNATPSARRYARENGVNLAEVSPKTNDLVRKEDIDKKQQAPASTQTTQQAPAKEEKKYNQYPTKPVIREKMSRRKKTAAKKLLEVSNNTAMLTTFNEVDMTNVMELRKRKKDQFMKDHDGTKLGFMSFFTKASVAALKKYPEVNAEIDGDDMITKQYYDIGVAVSTDDGLLVPFVRDCDKKNFAEIEAEIANLAVKAREKKLGLDDMVNGSFTITNGGIFGSMMSTPIINGNQAAILGMHSIITRPIAIDQDTIENRPMMYIALSYDHRIIDGKEAVGFLKTIKELIENPEDLLLES
>NC_022222.1|WP_000334509.1|1393966_1394776_-|hypothetical-protein
MCGLRSITLGTTNIEQTKHFMVDILGLNCEELLENSIRFGDADISPGTRLQFIQVPSEQLEESHFVGIGLRTPTDSGLEEYAEILSSKEIPFTTTKELNGNKYFSFEDNNGHIFSIYSNENNYGVGLGMPSFESAVNPLHQVQGLGPVILKVNHVDITGQILTNIFGLEVFAEYQPFDNADYHVQVFKIGTGGLGGEIHLMPVETEMTMPEYGAVDQVEFETKDADFFNQAKSRLDEVEIPYQTLEQDDIESIRITENSGLSFIFTLQK
>NC_022222.1|WP_000902174.1|1393734_1393938_-|hypothetical-protein
MLHETWKERTPIKKVEVINTDAKKFTVSDMLTVGKQYDVINETEEYYQIIDNSGLIGGYYKTYFKEV
>NC_022222.1|WP_020977258.1|1392762_1393554_-|MoxR-family-ATPase
MALKHYKNSDSTVFNDAKALFDLNKNILLKGPTGSGKTKLAETLSEVVDTPMHQVNCSVDLDTESLLGFKTIKTNAEGQQEIVFVDGPVIKAMKEGHILYIDEINMAKPETLPVLNGVLDYRRQITNPYTGEVIKAVPGFNVIAAINEGYVGTLPMNEALKNRFVVIHVDYIDGDILKNVIKEQSLLQDDKQIEQIIKFNEDLRTMSKQGQISEEAASIRALLDLCDLITVMPVERSIKRTIIDKLEDEREQQAIYNAVELNF
>NC_022222.1|WP_001283670.1|1390862_1392749_-|nitric-oxide-reductase-activation-protein-NorD
MSDRFIKFNDEQLDAKQVMMLQDLARLLLKNEQTQVKIQKFPYYNPVQNVLITSWFWSHRPSHIEMAGLKTDVMLAAYGYHMMDVQIVNEVVQDKTFKHPKFYQQLFKLLEDMRVLNSIKVERPSTAKLIDLRLDTRISYTESQIKVYRTKTQYTDLLFLYLEHAFLSQDFFDIPSIHSDLDDILVNMFLYLPNFFQNQNSEDNMYLAQRIMYQVDDILKEDMLNEYYYLPKTLYNTLASPEFEDLKRTDASQVDGQDDTSEDDDNQSEKADSKSADSESKGGAYLEMELHEGQNSETLGNDEAREGDATDDMTDMMTKKGKGSNDTLNREEGDAVGQSQAFQLDGVNKNVEIKWQIPEIEPQYVLEYQESKQDVQYEIKDLIQIIKKTIEREQRDARFNLTKGRLQKDLINWFIDDQYKLFYKKQDLSKSFDATFTLLIDASASMHDKMAETKKGVVLFHETLKALNIKHEILSFSEDAFDSDEHAQPNIINEIINYDYSTFEKDGPRIMALEPQDDNRDGVAIRVASERLMRRNQHQRFLIVFSDGEPSAFNYSQDGIIDTYEAVEMSRKFGIEVFNVFLSQDPITEDVEQTIHNIYGQYAIFVEGVAHLPGHLSPLLKKLLLKSL
>NC_022222.1|WP_001039275.1|1389294_1390638_-|branched-chain-amino-acid-transport-system-II-carrier-protein
MNKNTWVIGFTLFAMFFGAGNLIFPPNLGLDSGQFFWPAILAFVLTGIGLPLLGVIVGALDKEGYIGALNKISPKFSILFLIIIYLTIGPLFAIPRTASTSFEMTITPIIHSNSSIALFIFTIIYFIVVLYICLNPSKLIDRIGSLLTPLLLITILAMIIKGYLDFSGNSAGKGNEALYHSNFSSFAEGFTQGYLTMDAIAAIAFSMIVVNAVKLTGITKTNQIFKQTLTAGLIAAVALIFIYISLGYIGNHMPVSDMTLDQLKSKDRNIGTYLLTTMASTGFGSFGKYLLGIIVALACLTTACGLIVAVSEYFHRIVPKVSYKAFVLVFILMSFIIANQGLNAVISMSIPVLSIVYPVAITVVLLILIAKFIPTKRISQQIPVIIVFILSIFSVISKLGWLKINFIESLPLRAYSLEWFPVAIIATILGYLVGIFVKQDPIKYQQE
>NC_022222.1|WP_020977257.1|1388085_1389222_+|toxic-anion-resistance-protein
MTENKSFKESHPLDDFISAKELSNTTIQKEKLTIEQQKQVDTISKQINPLDNEGLLAFGSDLQKQMSQFSHQMLDEVQSKDVGPIGDTLSDLMSKLKSVNPNELNTDKPSMLKRIFSRAKSSINEIFSRMQSVSAQVDRITIQLQKHQTHLTRDIELLDTLYDKNKQYFDDLSLHIIAAQQKKLQLENEKLPQLQQQAQQSTNQMDIQQVADMQQFIDRLDKRIYDLQLSRQIALQTAPQIRMIQNVNQALAEKIQSSILTSIPLWKNQMAIALTLMRQRNAVAAQRAVTDTTNDLLTANAEMLKQNAIETATENERGIVDLDTLKRTQRNIIETIEETLIIQQHGREERQLAEKELQQLEQDLKSHLVNIKGPNKQS
>NC_022222.1|WP_000084773.1|1402877_1403492_-|phosphatase-PAP2-family-protein
MSQWKRISLLIVFTLVFGIIAFFHESRLGKWIDNEVYEFIYSSESFITTSIMLGATKVGEVWAMLCISLLLVAYLMLKRHKIEALFFALTMALSGILNPALKNIFDRERPTLLRLIDITGFSFPSGHAMGSTAYFGSGIYLLNRLNQGNSKGILIGLCAAMILLISISRVYLGVHYPTDIIAGIIGGVFCIILSTLLLRNKLIN
>NC_022222.1|WP_000160908.1|1403508_1404579_-|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase
MTKIAFTGGGTVGHVSVNLSLIPTALSQGYEALYIGSKNGIEREMIESQLPEIKYYPISSGKLRRYISLENAKDVFKVLKGILDARKVLKKEKPDLLFSKGGFVSVPVVIAAKSLNIPTIIHESDLTPGLANKIALKFAKKIYTTFEETLNYLPKEKADFIGATIREDLKNGNAHNGYQLTGFNENKKVLLVMGGSLGSKKLNSIIRENLDALLQQYQVIHLTGKGLKDDQVKKSGYIQYEFVKEDLTDLLAITDTVISRAGSNAIYEFLTLRIPMLLVPLGLDQSRGDQIDNANHFADKGYAKAIDEEQLTAQILLQELNEMEQERTRIINNMKSYEQSYTKEALFDKMIKDALN
>NC_022222.1|WP_000620194.1|1404590_1405100_-|GNAT-family-N-acetyltransferase
MIRLGKMSDLDQILNLVEEAKELMKEHDNEQWDDQYPLLEHFEEDIAKDYLYVLEENDKIYGFIVVDQDQAEWYDDIDWPVNREGAFVIHRLTGSKEYKGAATELFNYVIDVVKARGAEVILTDTFALNKPAQGLFAKFGFHKVGEQLMEYPPYDKGEPFYAYYKNLKE
>NC_022222.1|WP_020977260.1|1405499_1406990_-|S41-family-peptidase
MDDKQHKSSSDDERAEIATSNQDQQTNSSKRVHLKRWQFISILIGTILITAVITVVAYIFINQKISGLNKTDQANLNKIENVYKILNSDYFKKQNSDKLSKAAIDGMVKELKDPYSEYLTKEQTKSFNEGVSGDFVGIGAEMQKKNDQIMVTSPMKGSPAERAGIRPKDVITKVNGKSIKGKALDEVVKDVRGKENTEVTLTVQRGSEEKDVKIKREKIHVKSVEYKKKGKVGIITINKFQNDTSGELKDAVLKAHKDGLKKIVLDLRNNPGGLLDEAVKMANIFIDKGKTVVKLEKGKDTEAIQTSNDALKEAKDMDISILVNEGSASASEVFTGALKDYNKAKVYGSKTFGKGVVQTTREFKDGSLLKYTEMKWLTPDGHYIHGKGIKPDVTIDTPKYQSLNVIPNTKTFKVGDDDKNIKTIKIGLSALGYKVDNESTQFDQALENQVKAFQQANKLEVTGEFNKETNNKFTELLVEKANKHDDVLDKLINILK
>NC_022222.1|WP_000801007.1|1407181_1407403_-|hypothetical-protein
MKNYSFYQFVMTVRGRHDDKGRLAEEIFDDLAFPKHDDDFNILSDYIETHGDFTLPMSVFDDLYEEYTEWLKF
>NC_022222.1|WP_000473654.1|1407402_1407903_-|PTS-glucose-transporter-subunit-IIA
MFKKLFGKGKEVQKDIAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLDGEGFEVLVSSGDEVNVGDPLVRFNLEYINNNAKSVISPIIITNTDQAASINIYDENAVIKGETKVIDVTMN
>NC_022222.1|WP_000913315.1|1407914_1408343_-|peptide-methionine-(R)-S-oxide-reductase-MsrB
MLKKDKSELTDIEYIVTQENGTEPPFMNEYWNHFAKGIYVDKISGKPLFTSEEKFHSECGWPSFSKALDDDEIIELVDKSFGMLRTEVRSEESNSHLGHVFNDGPKESGGLRYCINSAAIQFIPYEKLEELGYGDLISHFDK
>NC_022222.1|WP_000159902.1|1408335_1408869_-|peptide-methionine-(S)-S-oxide-reductase-MsrA
MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNQTGHVEAVQITFDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQGIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA
>NC_022222.1|WP_042908694.1|1408958_1409798_-|fatty-acid-kinase-FakB2
MTKQIIVTDSTSDLSKEYLEANNIHVIPLSLTIEGASYVDQVDITSEEFINHIENDEDVKTSQPAIGEFISAYEELGKDGAEIISIHLSSGLSGTFNTAYQASQMVDANVTVIDSKSISFGLGYQIQHLVELVKEGVSTSEIVNKLNHLRENIKLFVVIGQLNQLIKGGRISKTKGLIGNLMKIKPIGTLDDGRLELVHNARTQNSSIQYLKKEIAEFIGDHEIKSVGVAHANVIEYVDKLKKVFNEAFHMNNYDINVTTPVISAHTGQGAIGLVVLKK
>NC_022222.1|WP_000175746.1|1409812_1410292_-|dihydrofolate-reductase
MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK

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Crispr_ID: NC_022222_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022222_5

1602128-1602211

Orphan

Consensus_repeat	Method
TGTTGGGGCCCCGTCCCCAACTTGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022222_5

>merge|NC_022222|5|1602128-1602211|CRISPRCasFinder
TGTTGGGGCCCCGTCCCCAACTTGCATTGCCTGTTGAATTTCTTTACCAAATTCTCTGTGTTGGGGCCCCATCCCCAACTTGCA

>NC_022222|5|4|1602128-1602211|CRISPRCasFinder
TGTTGGGGCCCCGTCCCCAACTTGCA	TTGCCTGTTGAATTTCTTTACCAAATTCTCTG
TGTTGGGGCCCCATCCCCAACTTGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022222.1\|WP_000648617.1\|1590863_1591487_-\|uridine-kinase	unknown	unknown	gnl\|CDD\|235492
NC_022222.1\|WP_020977311.1\|1598665_1601143_-\|ATP-dependent-RecD-like-DNA-helicase	unknown	unknown	gnl\|CDD\|273632
NC_022222.1\|WP_000939059.1\|1594938_1595367_-\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|223886
NC_022222.1\|WP_014937034.1\|1609455_1609584_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000752909.1\|1606458_1606641_-\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NC_022222.1\|WP_020977309.1\|1591486_1592755_-\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896
NC_022222.1\|WP_000009238.1\|1606272_1606419_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000409169.1\|1603568_1604711_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_022222.1\|WP_000102738.1\|1607247_1608522_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NC_022222.1\|WP_000567017.1\|1601144_1601813_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_022222.1\|WP_000682646.1\|1608682_1609456_-\|tRNA-threonylcarbamoyladenosine-dehydratase	unknown	unknown	gnl\|CDD\|224100
NC_022222.1\|WP_000704122.1\|1606740_1607163_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NC_022222.1\|WP_000044799.1\|1609916_1611683_-\|aspartate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234775
NC_022222.1\|WP_042908710.1\|1595693_1598324_-\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NC_022222.1\|WP_000985896.1\|1605022_1606036_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NC_022222.1\|WP_000134779.1\|1594615_1594924_-\|DUF1292-domain-containing-protein	unknown	unknown	gnl\|CDD\|184235
NC_022222.1\|WP_020977312.1\|1602449_1603568_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_022222.1\|WP_000137775.1\|1592766_1593690_-\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896
NC_022222.1\|WP_000342266.1\|1593692_1594331_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NC_022222.1\|WP_000426912.1\|1595370_1595631_-\|IreB-family-regulatory-phosphoprotein	unknown	unknown	gnl\|CDD\|180108

Protein	Function_ID	Function_description	E-value
NC_022222.1\|WP_000648617.1\|1590863_1591487_-\|uridine-kinase	gnl\|CDD\|235492	PRK05480, PRK05480, uridine/cytidine kinase; Provisional.	5.13835e-138
NC_022222.1\|WP_020977311.1\|1598665_1601143_-\|ATP-dependent-RecD-like-DNA-helicase	gnl\|CDD\|273632	TIGR01448, recD_rel, helicase, putative, RecD/TraA family. This model describes a family similar to RecD, the exodeoxyribonuclease V alpha chain of TIGR01447. Members of this family, however, are not found in a context of RecB and RecC and are longer by about 200 amino acids at the amino end. Chlamydia muridarum has both a member of this family and a RecD. [Unknown function, Enzymes of unknown specificity].	0
NC_022222.1\|WP_000939059.1\|1594938_1595367_-\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|223886	COG0816, COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair].	3.40149e-56
NC_022222.1\|WP_000752909.1\|1606458_1606641_-\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	4.22501e-07
NC_022222.1\|WP_020977309.1\|1591486_1592755_-\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	2.04114e-148
NC_022222.1\|WP_000409169.1\|1603568_1604711_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	0
NC_022222.1\|WP_000102738.1\|1607247_1608522_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NC_022222.1\|WP_000567017.1\|1601144_1601813_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	4.6095e-16
NC_022222.1\|WP_000682646.1\|1608682_1609456_-\|tRNA-threonylcarbamoyladenosine-dehydratase	gnl\|CDD\|224100	COG1179, COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism].	1.59061e-126
NC_022222.1\|WP_000704122.1\|1606740_1607163_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	5.58388e-46
NC_022222.1\|WP_000044799.1\|1609916_1611683_-\|aspartate--tRNA-ligase	gnl\|CDD\|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NC_022222.1\|WP_042908710.1\|1595693_1598324_-\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NC_022222.1\|WP_000985896.1\|1605022_1606036_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	2.42671e-173
NC_022222.1\|WP_000134779.1\|1594615_1594924_-\|DUF1292-domain-containing-protein	gnl\|CDD\|184235	PRK13678, PRK13678, hypothetical protein; Provisional.	1.28539e-26
NC_022222.1\|WP_020977312.1\|1602449_1603568_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_022222.1\|WP_000137775.1\|1592766_1593690_-\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	4.87045e-104
NC_022222.1\|WP_000342266.1\|1593692_1594331_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	1.23148e-73
NC_022222.1\|WP_000426912.1\|1595370_1595631_-\|IreB-family-regulatory-phosphoprotein	gnl\|CDD\|180108	PRK05473, IreB-like, IreB family regulatory phosphoprotein. IreB (EF1202) was characterized in Enterococcus faecalis as a small protein, well-conserved in the Firmicutes. It belongs to a system that includes the Ser/Thr protein kinase IreK, and phosphatase IreP, undergoes phosphorylation on threonine residues, and is involved in regulating cephalosporin resistance. This family was previously named DUF965 by Pfam model pfam06135.	3.05024e-47

>NC_022222.1|WP_000567017.1|1601144_1601813_-|tetratricopeptide-repeat-protein
MIDQQTIYQYIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDAEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMKNEDIDEAITHFKEAVTIDPKHLLSQHALKTFTKMKEEE
>NC_022222.1|WP_020977311.1|1598665_1601143_-|ATP-dependent-RecD-like-DNA-helicase
MSDPTLFDYSMIKGTVEAILFQNSDNFYTVLKVDTIETNEDFDTMPTVVGFLPNIVEGDVYTFKGQVVDHPRYGKQLKAETFEKEMPQTKEAIISYLSSDLFKGVGKKTAQNIVNTLGDNAINDILDDHSVLEKVSGLSKKKQKQIAEQISANQESEKIMIRLHDLGFGPKLSMAIYQFYLGDTLTILDRNPYQLIYDIKGIGFNKADQLARNIGIAYNDNERLKAALLYTLEEECIKQGHTYLPINVVIDLTVDVLNYQDEEVIEPEKLDEMLQYLNEEKRLIIDNEQVAIPSLYYSEIKSVQNLFRIKTHTNKLTEIEQSDLQMHIGEIEDANQVNYAASQKEALQTAINSKVMLLTGGPGTGKTTVIKGIVELYAEIHGLSLDYDDYVNDDYPVVLAAPTGRASKRLQESTGLEAMTIHRLIGWNQDTKPEDILENEINARLIIIDEMSMVDTWLFHQFLSAVPLDAQLIFVGDEDQLPSVGPGQVFKDLIESKAIPRVNLTEVYRQQDGSSIIELAHRMKLGQKIDITQRFHDRSFINCQANQIPTVVEKVVTSAVNKGYTMADIQVLAPMYKGNAGIKRLNQVLQDILNPKKKDTREIEFGDVVFRKGDKVLQLVNRPNDNIFNGDIGVIVGIFWAKENALNKDVLVVDFEGNEITFTKQDMMELTHAYCTSIHKSQGSEFPIVIMPIVKQYFRMLQRPILYTGLTRAKTSLVLLGDPEAFDIGLKTNGQARLTQLCTLLKNYFNSEDEEMPENTATNDTGASQTTIDDQVEASLSSNDSEEVTSDSTKTDTNVLTEATMFKIDPMINMGEITPYDFIER
>NC_022222.1|WP_042908710.1|1595693_1598324_-|alanine--tRNA-ligase
MKKLKASEIRQKYLDFFVEKGHMVEPSAPLVPIDDDTLLWINSGVATLKKYFDGRETPKKPRIVNSQKAIRTNDIENVGFTARHHTFFEMLGNFSIGDYFKQEAIEFAWEFLTSDKWMGMEPDKLYVTIHPEDMEAYNIWHKDIGLEESRIIRIEGNFWDIGEGPSGPNTEIFYDRGEAYGQDDPAEEMYPGGENERYLEVWNLVFSEFNHNKDHSYTPLPNKNIDTGMGLERMASVSQNVRTNYETDLFMPIMNEIEKVSGKQYLVNNEQDVAFKVIADHIRTIAFAISDGALPANEGRGYVLRRLLRRAVRFSQTLGINEPFMYKLVDIVADIMEPYYPNVKEKADFIKRVIKSEEERFHETLEDGLAILNELIKKAKVTTNEINGKDAFKLYDTYGFPIELTEEIAVQAGLKVDMTTFESEMQQQRDRARQARQNSQSMQVQSEVLKNITSASTFVGYDTATAQTTLTHLIYNGEEVSQVEAGETVYFMLTETPFYAVSGGQVADTGIVYNDNFEIAVSEVTKAPNGQNLHKGVVQFGQVNVGATVSAEVNQNDRRDIQKNHSATHLLHAALKSILGDHVNQAGSLVEADRLRFDFSHFGPMTNDEIDQVERLVNEEIWKGIDVNIQEMDIASAKEMGAMALFGEKYGDVVRVVNMAPFSIELCGGIHVRNTSEIGLFKIVSESGTGAGVRRIEALTGKAAFLYLEDIQEKFNTMKSQLKVKSDDQVVDKLTQLQDEEKALLKQLEQRDKEITSLKMGNIEDQVEEINGYKVLVTEVDVPNAKAIRSTMDDFKSKLQDTIIILASNVDDKVSMVATVPKSLTNNVKAGDLIKQMAPIVGGKGGGRPDMAQGGGTQPENISKSLSFIKDYIKNL
>NC_022222.1|WP_000426912.1|1595370_1595631_-|IreB-family-regulatory-phosphoprotein
MENFDKTMKFDYEELPTQDVRDVLNNVYRTLDERGYNAVNQIVGYLLSGDPAYIPRQNEARNQIRHIDRDVIMEELVSYYLKEQNK
>NC_022222.1|WP_000939059.1|1594938_1595367_-|Holliday-junction-resolvase-RuvX
MLQHKILGLDVGSRTVGIAISDIMGWTAQGLDTLRINEENNELGIDQLVDIIKKHNVGTVVIGLPKNMNNSIGFRGEASLTYKEKLLEAYPSIEIVMWDERLSTMAAERSLLEADVSRQKRKQVIDKMAAVFILQGYLDSLH
>NC_022222.1|WP_000134779.1|1594615_1594924_-|DUF1292-domain-containing-protein
MTEHNHDSQLEINNEEELLTLFDEEGNEVLYRKVLEFYHPEFKKEYVILAEEGAQSDEDDMIELVPMINEPDESGDGGKLVPIETDEEWDMIEEVVNTEMEE
>NC_022222.1|WP_000342266.1|1593692_1594331_-|O-methyltransferase
MDDLNKKYLIDLHQHQNSSIEVLREFAEVNEVPIVDRLTLDLIKQLIRMNNVKNILEIGTAIGYSSMQFASISDDIHVTTIERNETMIQYAKQNLATYHFENQVRIIEGNALEQFENVNDKVYDMIFIDAAKAQSKKFFEIYTPLLKHQGLVITDNVLYHGFVSDIGIVRSRNVRQMVKKVQDYNEWLIKQPGYTTNFLNIDDGLAISIKGE
>NC_022222.1|WP_000137775.1|1592766_1593690_-|U32-family-peptidase
MTELLVTPKSLSHMETLIDLGADAFVIGEQKFGLRLPGEFNRQQMTEAVALAHKNDKKVYAAVNGLFHNYHLDAVEDYINFLHEIRVDRIIFGDPAVVMYVKAQENPIPLHWNAETLVTNHFQCNYWGKRGASRAVLARELNLDEIINIKENSNVEIEVQVQGMTCMFQSKRMLLGNYYTFQDRQMKIERRNDEQSLLLYDEERQNNYPVYEDYNGTHIMSPNDICLIEELAPFFEAGIDSFKIDGILQTEEYINVVTEQYRQAIDLYNEDPEIYEDEKFMLMDPIEEIQPDHRPFDEGFLYKQTVY
>NC_022222.1|WP_020977309.1|1591486_1592755_-|U32-family-peptidase
MKTIEEIKSTPKTVMKKPELLAPAGNLEKLKIAVHYGADAVFLGGQEYGLRSNADNFTMEEIAEGVEFANHYGAKIYVTTNIIAHDENIEGLESYLRNLEKTGATGIIVADPLIIETCKEVAPKLEIHLSTQQSLSNYKAVEYWKEEGLDRVVLARETGAMEMREMKEKVDIEIEAFIHGAMCIAYSGRCTLSNHMTARDSNRGGCCQSCRWDYELLEVDDNGELDVFYNQGEVTPFAMSPKDLKLIESIPQMMDIGVDSLKIEGRMKSIHYIATVVSVYRKVIDAYAADPDNFKINPEWLIELDKCANRDTAPAFFEGTPGYEEQMFGQQQSKKSPFDFCGLVLDYNEDTKIATIQQRNNFKPGQEIEFFGPEIETFTQVVEAIYDEEGNSLDAARHPLQIVQIKVDRPIYPNNMMRKEIG
>NC_022222.1|WP_000648617.1|1590863_1591487_-|uridine-kinase
MKATTIIGIAGGSGSGKTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPTKKYADIIIPEGGSNKVAIDIMTTKIQSLVSKQ
>NC_022222.1|WP_020977312.1|1602449_1603568_-|tRNA-2-thiouridine(34)-synthase-MnmA
MSNKDIRVVVGMSGGVDSSVTAHVLKEQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIEVCNQIGIPYYAVNFEKEYWDKVFTYFLDEYKKGRTPNPDVMCNKEIKFKAFLDHAMNLGADYVATGHYARIHRHEDGHVEMLRGVDNNKDQTYFLNQLSQQQLSKVMFPIGDIEKSEVRRIAEEQGLVTAKKKDSTGICFIGEKNFKTFLSQYLPAQPGNMITLDGKKMGKHSGLMYYTIGQRHGLGIGGDGDPWFVVGKNLKDNVLYVEQGFHHDALYSDYLIASDYSFVNPEDNDLDQGFECTAKFRYRQKDTKVFVKRENDHALRVTFAEPVRAITPGQAVVFYQGDVCLGGATIDDVFKNEGQLNYVV
>NC_022222.1|WP_000409169.1|1603568_1604711_-|cysteine-desulfurase
MEIYADYAATTPVKPEVVDAMMTIYNSHYGNPSSIHAKGRDARKYLDESRRQIAQLLGADTHEIIFTSGATESNNTAIKGIVKANEQLGNHIITSKIEHHSVLHVFEQLEREGFDVTYLDVDDTGAIDLDQLEETITDKTILVSIMFVNNEVGTVQQIYDIQDIIAETNAYFHVDAVQAIGHLDVKFDEFEIDAMSITAHKFGGPKGVGALLVKDHVTLDYPQLGGEQELKRRAGTENLAQIVGMAKALQLAEKNRDDNNIHLMNLKEQFLVKLQERSIPFELNGSMTDATGHIVNLYFPFVEVETMLTLLDMAQIYVSSGSACTAGSTQPSHVLDAMFEDEERSNHSIRFSFNELTTENEINAIVAEIHKIYFKFKEES
>NC_022222.1|WP_000985896.1|1605022_1606036_+|LLM-class-flavin-dependent-oxidoreductase
MAIKYSALNLVPIREGEDERTAINDMVKLAQHLDELSYERYWIAEHHNAPNLVSSATALLIQHTLEHTKHIRVGSGGIMLPNHAPLIVAEQFGTMATLFPNRVDLGLGRAPGTDMMTASALRRDQHDGVYKFPEEVSLLQQYFGPAHQQAYVRAYPAVGKNVPLYILGSSTDSAHLAARKGLPYVFAGHFAPQQMKEAIEIYKTLFEPSDVLDEPYVIVCLNTIVAENDDEAQYLASSMAQVMVSITRGRMQPVQPPTHELQNILTPREYAMAMERQKISLIGSENTVQQKIQDFMETYGEVNEIMAISYIYDKDMQLDSYRRFKNVINQINEKSTL
>NC_022222.1|WP_000009238.1|1606272_1606419_-|hypothetical-protein
MSFMDKAKDAVEKFKNSDNEQVKNVKDKINEYTGSNNEEKKENEDKEK
>NC_022222.1|WP_000752909.1|1606458_1606641_-|CsbD-family-protein
MADESKFDQFKGNVKETVGNVTDNKELEKEGQQDKATGKAKEVVENAKNKITDAIDKLKK
>NC_022222.1|WP_000704122.1|1606740_1607163_-|Rrf2-family-transcriptional-regulator
MKISTKGRYGLTLMISLAKKEGQGCISLKSIAEENNLSDLYLEQLVGPLRNAGLIRSVRGAKGGYQLRVPAEEISAGDIIRLLEGPITFVESIESEPPAQKQLWIRMRDAVRDVLDNTTLKYLAEYVDTSEDLDGYMFYI
>NC_022222.1|WP_000102738.1|1607247_1608522_+|replication-associated-recombination-protein-A
MSTEPLASRMRPKNIDEIISQQHLVGPRGIIRRMVDTKKLTSMIFYGPPGIGKTSIAKAISGSTQYKFRQLNAVTNTKKDMQLVVEEAKMSGQVILLLDEIHRLDKAKQDFLLPHLENGKIVLIGATTSNPYHAINPAIRSRAQIFELYPLNDEDVRQALTRAIEDEENGLKTYQPKIDEDAMAYFSTQSQGDVRSALNALELAVLSADNDKDGYRHVTLQDAKDCLQKGAFVSDKDGDMHYDVMSAFQKSIRGSDVNAALHYLARLIEAGDLPTIVRRLLVISYEDIGLASPNAGQRTLAAIESAERLGLPEARIPLSQAVIELCLSPKSNSAMSAIDSALSDIRNGHVGQIPNHLKDGHYQGAKDLGRSIGYKYPHQYVNGYVSQQYLPDKLKNKIYYEPKTTSKSEQQLKEIYNNLLKQRP
>NC_022222.1|WP_000682646.1|1608682_1609456_-|tRNA-threonylcarbamoyladenosine-dehydratase
MKHQFSRNELAIGQQGLDLLKQQTVVILGVGGVGSFAAEALARTNIGHIILIDKDDVDITNVNRQLHALTTTVGQSKVSLMEERIKLINPDCKVTPLHMFYTEETYEEIFDNYDIDYFVDASDTIMYKVHLMKECLDRGIKVISSMGAANKTDPTRFTISDISKTHTDPMAKIIRQKLKKLGIRKGIPVVFSDESPIVIREDVKDIVGDKNAINRKGQMPPSSNAFVPSVVGLICASYVVNDVLKDIPVRRIKDKGQ
>NC_022222.1|WP_014937034.1|1609455_1609584_-|hypothetical-protein
MGLIAFNNCFLVEFWKNNQSNNAKYKILSYYVLMYKSVKEVK
>NC_022222.1|WP_000044799.1|1609916_1611683_-|aspartate--tRNA-ligase
MSKRTTYCGLVTEAFLGQEITLKGWVNNRRDLGGLIFVDLRDREGIVQVVFNPAFSEEALKIAETVRSEYVVEVQGTVTKRDPETVNPKIKTGQVEVQVTNIKVINKSETPPFSINEENVNVDENIRLKYRYLDLRRQELAQTFKMRHQITRSIRQYLDDEGFFDIETPVLTKSTPEGARDYLVPSRVHDGEFYALPQSPQLFKQLLMISGFDKYYQIVKCFRDEDLRADRQPEFTQVDIEMSFVDQEDVMQMGEEMLKKVVKEVKGVEINGAFPRMTYKEAMRRYGSDKPDTRFEMELIDVSQLGRDMDFKVFKDTVENDGEIKAIVAKGAAEQYTRKDMDALTEFVNIYGAKGLAWVKVVEDGLTGPIGRFFETENVETLLTLTGAEAGDLVMFVADKPNVVAQSLGALRVKLAKELGLIDETKLNFLWVTDWPLLEYDEDAKRYVAAHHPFTSPKEADIAKLGTAPEEAEANAYDIVLNGYELGGGSIRIHDGELQEKMFEVLGFTKEQAQEQFGFLLDAFKYGAPPHGGIALGLDRLVMLLTNRTNLRDTIAFPKTASATCLLTNAPGEVSDKQLEELSLRIRH

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Crispr_ID: NC_022222_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022222_6

1987071-1987159

Orphan

Consensus_repeat	Method
GTTTTTGACTGACTTCTCAATCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022222_6

>merge|NC_022222|6|1987071-1987159|CRISPRCasFinder
GTTTTTGACTGACTTCTCAATCAATTTATAACTTTATTATACATAATCGTTTTTCTTTTGCAATAGTTTTTCGACTGACTTCTCAATCA

>NC_022222|6|5|1987071-1987159|CRISPRCasFinder
GTTTTTGACTGACTTCTCAATCA	ATTTATAACTTTATTATACATAATCGTTTTTCTTTTGCAATAG
TTTTTCGACTGACTTCTCAATCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022222.1\|WP_000708434.1\|1986369_1986516_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_001823225.1\|1995849_1995984_-\|delta-lysin-family-phenol-soluble-modulin	unknown	unknown	gnl\|CDD\|173213
NC_022222.1\|WP_000153640.1\|1986834_1987053_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NC_022222.1\|WP_001103944.1\|1985844_1986165_-\|DUF1474-family-protein	unknown	unknown	gnl\|CDD\|369323
NC_022222.1\|WP_020977426.1\|1982484_1982865_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000179346.1\|1987913_1989086_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271189
NC_022222.1\|WP_020977427.1\|1986512_1986830_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|200128
NC_022222.1\|WP_020977425.1\|1981846_1982488_-\|mobile-element-associated-protein	unknown	unknown	gnl\|CDD\|374630
NC_022222.1\|WP_020977430.1\|1992073_1993282_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275319
NC_022222.1\|WP_000447470.1\|1983194_1984895_-\|DUF927-domain-containing-protein	unknown	unknown	gnl\|CDD\|227806
NC_022222.1\|WP_001058486.1\|1986167_1986377_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_001105715.1\|1996219_1996783_+\|accessory-gene-regulator-AgrB	unknown	unknown	gnl\|CDD\|214819
NC_022222.1\|WP_000867953.1\|1994465_1995251_+\|carbon-nitrogen-family-hydrolase	unknown	unknown	gnl\|CDD\|143607
NC_022222.1\|WP_020977429.1\|1991305_1992049_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_022222.1\|WP_000917289.1\|1990846_1991131_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NC_022222.1\|WP_001288441.1\|1980791_1981136_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_020977428.1\|1989154_1990771_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NC_022222.1\|WP_000522383.1\|1993478_1994105_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|226090
NC_022222.1\|WP_001002689.1\|1984908_1985778_-\|primase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|214926
NC_022222.1\|WP_000620857.1\|1987225_1987900_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379188

Protein	Function_ID	Function_description	E-value
NC_022222.1\|WP_001823225.1\|1995849_1995984_-\|delta-lysin-family-phenol-soluble-modulin	gnl\|CDD\|173213	PRK14752, PRK14752, delta-lysin family phenol-soluble modulin.	4.75617e-14
NC_022222.1\|WP_000153640.1\|1986834_1987053_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	9.85461e-11
NC_022222.1\|WP_020977427.1\|1986512_1986830_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|200128	TIGR01764, Probable_excisionase, DNA binding domain, excisionase family. An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General].	1.56139e-16
NC_022222.1\|WP_000179346.1\|1987913_1989086_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.55725e-47
NC_022222.1\|WP_001103944.1\|1985844_1986165_-\|DUF1474-family-protein	gnl\|CDD\|369323	pfam07342, DUF1474, Protein of unknown function (DUF1474). This family consists of several bacterial proteins of around 100 residues in length. Members of this family seem to be found exclusively in Staphylococcus aureus. The function of this family is unknown.	1.63366e-18
NC_022222.1\|WP_020977425.1\|1981846_1982488_-\|mobile-element-associated-protein	gnl\|CDD\|374630	pfam16560, SAPI, Putative mobile pathogenicity island. SAPI is a family of putative Gram-positive mobile pathogenicity island proteins. SAPIs are responsible for many superantigen-related diseases in humans as they carry two or more superantigens.	1.75994e-111
NC_022222.1\|WP_020977430.1\|1992073_1993282_-\|hypothetical-protein	gnl\|CDD\|275319	TIGR04526, predic_Ig_block, putative immunoglobulin-blocking virulence protein. Members of this family are putative virulence proteins of Mycoplasma and Ureaplasma species. Members share a region of sequence similarity (see TIGR04524) with protein M, a Mycoplasma genitalium protein that binds a conserved light chain region of IgG and blocks its protective function of antigen-specific binding. The seed alignment for this model includes an N-terminal signal-anchor domain and a proline-rich linker domain, and a C-terminal extension, in addition to the protein M-like domain recognized by TIGR04524. [Cellular processes, Pathogenesis].	5.7811e-11
NC_022222.1\|WP_000447470.1\|1983194_1984895_-\|DUF927-domain-containing-protein	gnl\|CDD\|227806	COG5519, COG5519, Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair].	1.18395e-165
NC_022222.1\|WP_001105715.1\|1996219_1996783_+\|accessory-gene-regulator-AgrB	gnl\|CDD\|214819	smart00793, AgrB, Accessory gene regulator B. The accessory gene regulator (agr) of Staphylococcus aureus is the central regulatory system that controls the gene expression for a large set of virulence factors. The arg locus consists of two transcripts: RNAII and RNAIII. RNAII encodes four genes (agrA, B, C, and D) whose gene products assemble a quorum sensing system. At low cell density, the agr genes are continuously expressed at basal levels. A signal molecule, autoinducing peptide (AIP), produced and secreted by the bacteria, accumulates outside of the cells. When the cell density increases and the AIP concentration reaches a threshold, it activates the agr response, i.e. activation of secreted protein gene expression and subsequent repression of cell wall-associated protein genes. AgrB and AgrD are essential for the production of the autoinducing peptide which functions as a signal for quorum sensing. AgrB is a transmembrane protein. AgrB is involved in the proteolytic processing of AgrD and may have both proteolytic enzyme activity and a transporter facilitating the export of the processed AgrD peptide.	3.67824e-45
NC_022222.1\|WP_000867953.1\|1994465_1995251_+\|carbon-nitrogen-family-hydrolase	gnl\|CDD\|143607	cd07583, nitrilase_5, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	2.11308e-126
NC_022222.1\|WP_000917289.1\|1990846_1991131_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	5.94304e-45
NC_022222.1\|WP_020977429.1\|1991305_1992049_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.49995e-11
NC_022222.1\|WP_000620857.1\|1987225_1987900_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	1.58614e-10
NC_022222.1\|WP_000522383.1\|1993478_1994105_+\|nitroreductase-family-protein	gnl\|CDD\|226090	COG3560, FMR2, Predicted oxidoreductase related to nitroreductase [General function prediction only].	4.41942e-115
NC_022222.1\|WP_001002689.1\|1984908_1985778_-\|primase-C-terminal-domain-containing-protein	gnl\|CDD\|214926	smart00942, PriCT_1, Primase C terminal 1 (PriCT-1). This alpha helical domain is found at the C terminal of primases.	1.21323e-15
NC_022222.1\|WP_020977428.1\|1989154_1990771_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0

>NC_022222.1|WP_000153640.1|1986834_1987053_-|helix-turn-helix-transcriptional-regulator
MTILANTRKFKEAMFLKGFNLSDLSRETGVGISYLSQIINGKKIPSPKLAKKMAEVLQVEVNELFEFEVKEA
>NC_022222.1|WP_020977427.1|1986512_1986830_-|helix-turn-helix-domain-containing-protein
MFNINIDEDEARELLEQAINARVDELAKEKYFMTYKELANYLNLSKPTIEESLINNGMKYYMVGSTYRFKKSDVDEFMEQLTAHMNIQNNDFKQVNIKKLLEARQ
>NC_022222.1|WP_000708434.1|1986369_1986516_-|hypothetical-protein
MKIYLTYICLVSLLTILLLAISNMYVAFSVYAWLITLGCNLTGGLENE
>NC_022222.1|WP_001058486.1|1986167_1986377_-|hypothetical-protein
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
>NC_022222.1|WP_001103944.1|1985844_1986165_-|DUF1474-family-protein
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKFHEIEKASSDVSLATESDDAKKLKITE
>NC_022222.1|WP_001002689.1|1984908_1985778_-|primase-C-terminal-domain-containing-protein
MNEIKLEYDTHVSVVHYESLDSRSFKSFSKPEWSKLVNKLSVPIEANYKYARGVAVYGDIKDGANDHGETIKKHRNDVNVIYRDVIVLDYDEINDLKQLHEAISSVLSSVAWYWHTSFSHTTEQARIRLYIPLNERISADDYRKYTKVLANKIGHKVDEGSYQPSRCFALPVIQKGHIFIKRVNDCPIMNVDMLEQWSKEFEQSNASPNVIGYTRRDSEYWRELCFGTTEGNRNNALASLIGHLLRCHVNDYIVYSFALLWGQFACKPPMKEQEINATFQSILNKHYNN
>NC_022222.1|WP_000447470.1|1983194_1984895_-|DUF927-domain-containing-protein
METGKSDVLDKIEKINKKDSALQEIIPKGYEIEHHQCGVALYQLIPSKKEGEPDKKVFITNTIPQITERFEDIESNEVSFNMLFYDNKTPVNIAVSAEEISDSRQLLKLVNKKLDVTSSTSTKLVDYINVSKRYNPPLNVKVATRLGHVKGYFIYPYQEVMKDSNIKLFSNDKGFQKLIDSFQSKGTLEGYSKKVFGQIKDLPMVMVMLYASLGSVLLREFGLQPFIVEISGSTSTGKTFTLNLVSSVWGTSDLITTWSSTQNSIESMASFLNSFPMFKDDTRNTHPKFVTSATYNFSSGESKSRSNINLTLNAKKEWRNILISTGESSIANMADEKAGVSARVVTLQDQPYPDNFDFTTLDKSFRENYGTLGLAFIKQYESKKDVYKNAFESYQRYFNQKGSNEIMQRLGRAFALLQVTGEVLNDIDGFEHDHFKIIEQTYDSMVKNNKTIDKPKQLLEELLQYLDANRNNIAGDGYSSVKNGDTKAIYKRDYLCILGQTVYDKLGHEMQTITGQWDKKGYLITSKDRIQKEVRFNSQKNRGYAIKDEIIKELGFDFSNSHNPYN
>NC_022222.1|WP_020977426.1|1982484_1982865_-|hypothetical-protein
MDKEQLKIYIYDYVKEYKEIPIYQLEDLFKEINHDYIGRTSITHDKDENVVFWSGWNKITMFALIELVKSEQLDLVYRGSFVMRYLLDGRVPNLPLAICYPEDGQQTDVLSWVPMVLRINKEEKIK
>NC_022222.1|WP_020977425.1|1981846_1982488_-|mobile-element-associated-protein
MNIETIVNEFETRAGTLLRYYTGLLEHSKVQPCCFKLYNDPFDMVYVVMNNKLFGHVYIKDCKVRKSFELASPKHTEGLIRSIEGHYVGYELHDGKQLSISDMMASQLFEDEYFMYGLQTYVESNNSDVFEYLENGFDTDTLEGIQSSNTDVISNIEMLYQIATGINEPAPELVEGLRLVTEFVQDEKAAQEDYTGLERKLNDLKASYYSISK
>NC_022222.1|WP_001288441.1|1980791_1981136_-|hypothetical-protein
MSEFEVKEKTYNLPNEHRQVLNVIRNTSNKYITKTKLLNQLGYEVNKANNRWLTQVITSLIINYHYPIGYSYKKDTRGYYIIKTQADKIEAIKSIKGLIEGSQNRLKALEEIEV
>NC_022222.1|WP_000620857.1|1987225_1987900_+|helix-turn-helix-transcriptional-regulator
MIRNRLSELLSERGLKISRVAKDVKIARSSLTSMAQNDSEMIRYDAIDKLCSYLHISPSEFFEHNPINFDFTFDEEPNYKINDVFEGFEVTANITHAFSIENFDFEILVDVELDNRQKLNFDLDVSYKETEKITNSQHRFIFTIKNEDENIGLKKYVDSLSAGLKNLLFKKINQKLSGYVSEIIVKNIDDIEELFPNKGEKSTTLHKEILQTDSRLSSDIFKEY
>NC_022222.1|WP_000179346.1|1987913_1989086_+|tyrosine-type-recombinase/integrase
MASYEKRGNTWRYRISLGKDAETGKYKYISNSGFKRKSDAKHHAEMVERQLRNGDYIAPSTSTFKQVADDWISQYANEVKVSSVRAREKAINHAIERFNNKPIQTINKHEYQRFVNDISAQYSKNYVDSIIASTNMIFKYAYDMKLIRIMPSEGIKRPKKKISVEELEDTEIHKKFLEKDELFQFLEVAKNHHSPQNSFEVFCTLAYTGMRAGELLALKWSDIDFENNTINITKTYYNPNNNKKQFQILTPKTESSIGKISVDPHVIKLLKNYKVDVQDTWKNELYVDNNFVFTDVNGYPLVIKKLQLWIKAILKKTDITNKQISTHSFRHTHCALLIEAGVHIKEIQERLRHKDINTTMNIYAKITNSYKKDASQKFSKLMENVSKDLF
>NC_022222.1|WP_020977428.1|1989154_1990771_-|chaperonin-GroEL
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDVLPLLEQVVQSNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNVYQKVSEIEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATNEWVNMLETGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
>NC_022222.1|WP_000917289.1|1990846_1991131_-|co-chaperone-GroES
MLKPIGNRVIIEKKEQEQTTKSGIVLTDSAKEKSNEGVIVAVGTGRLLNDGTRVTPEVKEGDRVVFQQYAGTEVKRDNETYLVLNEEDILAVIE
>NC_022222.1|WP_020977429.1|1991305_1992049_+|CPBP-family-intramembrane-metalloprotease
MTRLWASLLTVIIYILSQFLPLLIVKKLPFVQYSGIELTKAVIYIQLVLFLIAATTIILINLKIKNPTKLELEVKEPKKYIIPWALLGFALVMIYQMVVSIVYTQIFGTQQTSPNTERLIVIARKIPLFIFFVSIVGPLLEEYVFRKVIFGELFNAIKGNRIVAFAIATTVSSLIFALAHNDYKFIPIYFGMGVIFSLAYVWTKRLAVPIIIHMLQNGFVVIFQLLNPESLKKATEQANFIYHIFIP
>NC_022222.1|WP_020977430.1|1992073_1993282_-|hypothetical-protein
MSYHWFKKMLLSTSILILSSSSLGLATDTVEAKDNLNEEKPTTNLNHNVTSPSVNSEINNNETGTPPESNQTGNEGTDSNSRDANPDSNNVKPDSNNQNPSPDSKPDPNNPSPVPNPKPDPDKPKPNPEPKPDPDNPKPKPDPKPDPDNPKPKPDPDKPKPNPDPKPDPNKPNPNPSPDPNQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGNSQNPTGNDFVSQRFLALANGAYKYNPYILNQINQLGKEFGEVTDEDIYNIIRKQNFSGNAYLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRSFEPHEKDDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNESQRR
>NC_022222.1|WP_000522383.1|1993478_1994105_+|nitroreductase-family-protein
MGLFKKDKKAMTFDNAMEERRSIYNLKDSISISDDELESMIAHAVKHVPSSFNSQSTRIVLLLNDNNNKFWDNTKAILKEVMGENRDFEPTEQKIDNFKHSYGTILFYEDQDVVSGLQEQMPNYYDNFAIWSTQTNAMHQFAIWTALATKGIGASLQHYNPLVDEMTSNEFNIPKSWKLIAQMPFGDIREAAGEKSFNPVEDRFVIKK
>NC_022222.1|WP_000867953.1|1994465_1995251_+|carbon-nitrogen-family-hydrolase
MKVQIYQLPIIFGDSSKNETQITQWFEKNMNDEVDVVVLPEMWNNGYDLEHLNEKADNNLGQSFSFIKHLAEKYKVDIVAGSVSNIRNNQIFNTAFSVNKSGQLINEYDKVHLVPMLREHEFLTAGENVAEPFQLSDGTYVTQLICYDLRFPELLRYPARSGAKIAFYVAQWPMSRLQHWHSLLKARAIENNMFVIGTNSTGFDGNTEYAGHSIVINPNGDLVGELNESADILTVDLNLNEVEQQRENIPVFKSIKLDLYK
>NC_022222.1|WP_001823225.1|1995849_1995984_-|delta-lysin-family-phenol-soluble-modulin
MSCLILRIFILIKEGVISMAQDIISTISDLVKWIIDTVNKFTKK
>NC_022222.1|WP_001105715.1|1996219_1996783_+|accessory-gene-regulator-AgrB
MNYFDNKIDQFATYLQKRNNLDHIQFLQVRLGMQVLAVNIGKLIVMYTIAYILNIFLFTLITNLTFYLIRRHAHGAHAPSSFWCYVESIFLFTLLPLILVNYHINFLIMTIMTVIAIGMIIRYAPAATKKKPIPVRLIKRKRNYAIIVSLIFFIITLIIKEPFAQFIQLGIIIEAITLLPIFFVRRT

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Crispr_ID: NC_022222_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022222_7

2116428-2116514

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTTATGCA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_022222_7

>merge|NC_022222|7|2116428-2116514|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTTCAACTTTAGTTGTTAGGGGCTCTTATGCA

>NC_022222|7|6|2116428-2116514|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCA	TGCGCTTAGCGCAGGCGCTCCTACTTTTT
CAACTTTAGTTGTTAGGGGCTCTTATGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022222.1\|WP_000003759.1\|2113754_2114075_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_022222.1\|WP_064484069.1\|2121346_2121424_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000083804.1\|2126531_2128082_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_022222.1\|WP_020977457.1\|2108384_2108798_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NC_022222.1\|WP_001127960.1\|2111563_2112502_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NC_022222.1\|WP_000070865.1\|2107741_2108185_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NC_022222.1\|WP_042908741.1\|2111302_2111533_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000123402.1\|2109255_2110629_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NC_022222.1\|WP_001024095.1\|2112937_2113603_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NC_022222.1\|WP_020977464.1\|2123031_2123814_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_022222.1\|WP_000334462.1\|2124045_2125851_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_022222.1\|WP_000019732.1\|2114076_2115054_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NC_022222.1\|WP_001802298.1\|2116917_2117022_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_020977465.1\|2128116_2130249_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_022222.1\|WP_020977458.1\|2115319_2116411_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000160304.1\|2106910_2107621_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_022222.1\|WP_020977463.1\|2122106_2122964_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_022222.1\|WP_001066124.1\|2119018_2119780_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|181681
NC_022222.1\|WP_001292149.1\|2130260_2130695_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_022222.1\|WP_020977460.1\|2117733_2119026_+\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950

Protein	Function_ID	Function_description	E-value
NC_022222.1\|WP_000003759.1\|2113754_2114075_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NC_022222.1\|WP_020977457.1\|2108384_2108798_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	2.65882e-44
NC_022222.1\|WP_001127960.1\|2111563_2112502_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.24075e-129
NC_022222.1\|WP_000083804.1\|2126531_2128082_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_022222.1\|WP_000070865.1\|2107741_2108185_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	5.87929e-68
NC_022222.1\|WP_000123402.1\|2109255_2110629_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.86989e-06
NC_022222.1\|WP_001024095.1\|2112937_2113603_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.27122e-47
NC_022222.1\|WP_020977464.1\|2123031_2123814_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.6149e-106
NC_022222.1\|WP_000334462.1\|2124045_2125851_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_022222.1\|WP_000019732.1\|2114076_2115054_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	5.6931e-108
NC_022222.1\|WP_020977465.1\|2128116_2130249_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	1.12579e-66
NC_022222.1\|WP_000160304.1\|2106910_2107621_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NC_022222.1\|WP_020977463.1\|2122106_2122964_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	3.45076e-60
NC_022222.1\|WP_001066124.1\|2119018_2119780_+\|ATP-binding-protein	gnl\|CDD\|181681	PRK09183, PRK09183, transposase/IS protein; Provisional.	8.44204e-69
NC_022222.1\|WP_001292149.1\|2130260_2130695_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
NC_022222.1\|WP_020977460.1\|2117733_2119026_+\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.39708e-28

>NC_022222.1|WP_020977458.1|2115319_2116411_+|hypothetical-protein
MFTYFKSALKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQTIAIYSQFGQKPPGDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGIYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPVFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPENNQPK
>NC_022222.1|WP_000019732.1|2114076_2115054_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNATATKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESMICSGTHSHSHNHHAHHHAHVH
>NC_022222.1|WP_000003759.1|2113754_2114075_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NC_022222.1|WP_001024095.1|2112937_2113603_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFDGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGEQDIKDALTQFEIEKD
>NC_022222.1|WP_001127960.1|2111563_2112502_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NC_022222.1|WP_042908741.1|2111302_2111533_-|hypothetical-protein
MKQFLYIALVFGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NC_022222.1|WP_000123402.1|2109255_2110629_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NC_022222.1|WP_020977457.1|2108384_2108798_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDHIYFESQAIIQLITALPNRTKLLGVGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNVKVKLTD
>NC_022222.1|WP_000070865.1|2107741_2108185_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLEKAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NC_022222.1|WP_000160304.1|2106910_2107621_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NC_022222.1|WP_001802298.1|2116917_2117022_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NC_022222.1|WP_020977460.1|2117733_2119026_+|IS21-family-transposase
MKLSLDINTDFEVTTLTDLPKLKIVMENLNMKINKSEIARHMGVDRRTVDKYLNGFEPTKKRNRQSIIDKYYPIIEKLLSDTSEQKFYYKRILWQYLKDKHGLTCAYSTFRAYILKHDEFNRYFMKGYQRMSPKGTTRFETKAGHQAQFDWKEGINFKTKDNQIVSLNIGVLLLPYSRFVIMQVTMNKSSDVLFNLLTQAFELMGGVPNELVTDNMKTVMDQPRTERTNGQINRRFKQFADDFNFKVKPCVAGRPRTKGKVESIMKILDEIHAYQGELYLEEIPKFISNLNERLNYSVHTSTGKIPIIALEKEKSFLQPLPNVNVRNSYKVKHKYLKVNHSNMITYKSNQYSVPAEYCGKIVEVQVYDQKLHVYYNTKSICEHLITQRKLNYQKEHYLETLSSSFGNREMDDINQIAIDNLNAIGELYDE
>NC_022222.1|WP_001066124.1|2119018_2119780_+|ATP-binding-protein
MNNSTNYKRLKANLEYLKMNQMINHLDDVIDFSIKNNLSFIDTLIKLSDYEIEIKEKNLIESMVKVAAFPFKKEISDFDFNFQPSINQQEIWDFTDLRFIEKYQNIVFLGSSGVGKTHLATGIGMAAAKNRVSTYFIKCHHLIENLRKAKLENRLENRLKHYSKYKLLIIDEIGYLPIGSEDAKLFFQLIDLRYEKKSTIFTTNINFNLWNEIFDDPKIANAILDRILHHSSVVKITGKSYRLKDHSPKKEIT
>NC_022222.1|WP_064484069.1|2121346_2121424_+|hypothetical-protein
MTSKTLFHNNVKSLEFIMITINKNR
>NC_022222.1|WP_020977463.1|2122106_2122964_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIQQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIEHFGINQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NC_022222.1|WP_020977464.1|2123031_2123814_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINGGDKWILYGLNGAGKTTLLNILNAYEPATTGDVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALIGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NC_022222.1|WP_000334462.1|2124045_2125851_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKAADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVTLQLISYYAALHRDLDVDKPRNLAKSVTVE
>NC_022222.1|WP_000083804.1|2126531_2128082_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFFGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTKEPKQDLEAATAQMETTKGKKSSVASKLVSSDKDAKVEENVNTEAKTNADESSTLEDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NC_022222.1|WP_020977465.1|2128116_2130249_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGADSDLNDLKQSIAQHQIIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDIDGNTSFENEQTSYLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NC_022222.1|WP_001292149.1|2130260_2130695_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA

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Crispr_ID: NC_022222_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022222_8

2393848-2393940

Orphan

Consensus_repeat	Method
TTCTTCAAATTTATTTGTTAGAAAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022222_8

>merge|NC_022222|8|2393848-2393940|CRISPRCasFinder
TTCTTCAAATTTATTTGTTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCTACTACGTTCCTTTGTCTTCTTCAAATTTATTTGTTAGAAAG

>NC_022222|8|7|2393848-2393940|CRISPRCasFinder
TTCTTCAAATTTATTTGTTAGAAAG	GCTTATGCAGTTGACGTTTTACGTCCTACTACGTTCCTTTGTC
TTCTTCAAATTTATTTGTTAGAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022222.1\|WP_000038954.1\|2389886_2391326_-\|multidrug-efflux-MFS-transporter-MdeA	unknown	unknown	gnl\|CDD\|129794
NC_022222.1\|WP_001125208.1\|2391757_2392444_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518
NC_022222.1\|WP_020977548.1\|2400791_2401907_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
NC_022222.1\|WP_000479576.1\|2388286_2389006_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_022222.1\|WP_000594519.1\|2396136_2397066_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	unknown	unknown	gnl\|CDD\|369625
NC_022222.1\|WP_020977544.1\|2397632_2398580_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	unknown	unknown	gnl\|CDD\|369625
NC_022222.1\|WP_000825921.1\|2388986_2389766_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270429
NC_022222.1\|WP_000762708.1\|2391499_2391604_+\|putative-metal-homeostasis-protein	unknown	unknown	unknown
NC_022222.1\|WP_020977542.1\|2384976_2385576_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565
NC_022222.1\|WP_020977550.1\|2402893_2404252_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NC_022222.1\|WP_014532694.1\|2394144_2394240_-\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_020977549.1\|2401884_2402892_-\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NC_022222.1\|WP_000792557.1\|2394334_2395645_+\|B-domain-containing-protein	unknown	unknown	gnl\|CDD\|288473
NC_022222.1\|WP_000019123.1\|2392771_2393638_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NC_022222.1\|WP_020977545.1\|2398581_2399559_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	unknown	unknown	gnl\|CDD\|273388
NC_022222.1\|WP_000819843.1\|2385594_2385957_-\|DUF4467-domain-containing-protein	unknown	unknown	gnl\|CDD\|291399
NC_022222.1\|WP_020977546.1\|2399610_2400078_-\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|377623
NC_022222.1\|WP_020977543.1\|2386211_2387462_+\|FemA/FemB-family-glycyltransferase-FmhA	unknown	unknown	gnl\|CDD\|367067
NC_022222.1\|WP_000615461.1\|2387558_2388290_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_022222.1\|WP_020977547.1\|2400088_2400781_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342

Protein	Function_ID	Function_description	E-value
NC_022222.1\|WP_000038954.1\|2389886_2391326_-\|multidrug-efflux-MFS-transporter-MdeA	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	7.87495e-92
NC_022222.1\|WP_000792557.1\|2394334_2395645_+\|B-domain-containing-protein	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	1.40953e-27
NC_022222.1\|WP_020977548.1\|2400791_2401907_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	3.10189e-138
NC_022222.1\|WP_000479576.1\|2388286_2389006_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.98247e-78
NC_022222.1\|WP_001125208.1\|2391757_2392444_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167
NC_022222.1\|WP_020977544.1\|2397632_2398580_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.75226e-91
NC_022222.1\|WP_000825921.1\|2388986_2389766_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.11829e-100
NC_022222.1\|WP_020977549.1\|2401884_2402892_-\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NC_022222.1\|WP_020977542.1\|2384976_2385576_-\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	1.10961e-30
NC_022222.1\|WP_020977550.1\|2402893_2404252_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NC_022222.1\|WP_020977545.1\|2398581_2399559_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	1.08902e-127
NC_022222.1\|WP_000019123.1\|2392771_2393638_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	3.68728e-89
NC_022222.1\|WP_000594519.1\|2396136_2397066_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.31899e-97
NC_022222.1\|WP_000819843.1\|2385594_2385957_-\|DUF4467-domain-containing-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	3.11961e-31
NC_022222.1\|WP_020977546.1\|2399610_2400078_-\|QueT-transporter-family-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.00211553
NC_022222.1\|WP_020977543.1\|2386211_2387462_+\|FemA/FemB-family-glycyltransferase-FmhA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0
NC_022222.1\|WP_000615461.1\|2387558_2388290_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	3.20826e-144
NC_022222.1\|WP_020977547.1\|2400088_2400781_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	4.81842e-130

>NC_022222.1|WP_000019123.1|2392771_2393638_-|cation-transporter
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNAPRLFKEDDVVPNAITIIVSLISGLIMLIVFAVNQSLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>NC_022222.1|WP_001125208.1|2391757_2392444_-|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>NC_022222.1|WP_000762708.1|2391499_2391604_+|putative-metal-homeostasis-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>NC_022222.1|WP_000038954.1|2389886_2391326_-|multidrug-efflux-MFS-transporter-MdeA
MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGIVLVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILAHASKNFSPTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
>NC_022222.1|WP_000825921.1|2388986_2389766_-|transporter-substrate-binding-domain-containing-protein
MKRLLFVMIAFVFILAACGNNSSKDKEANKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKEEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSRSAFAFSKKADDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>NC_022222.1|WP_000479576.1|2388286_2389006_-|amino-acid-ABC-transporter-permease
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>NC_022222.1|WP_000615461.1|2387558_2388290_-|amino-acid-ABC-transporter-ATP-binding-protein
MIQLNNIHKSFNDVEVIKGIDLSVEQGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVYVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKDEARGKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAKEVSNNIVFIHEGMIGEQGAPEEMFNRPKTEELRRFLNVINEE
>NC_022222.1|WP_020977543.1|2386211_2387462_+|FemA/FemB-family-glycyltransferase-FmhA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKQNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDTLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEALEENPNSKKNIMKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPLLYKVKTYLNHKRR
>NC_022222.1|WP_000819843.1|2385594_2385957_-|DUF4467-domain-containing-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYDFSDKRVSYKQDFDSRRYYQQHDADYHEENMTN
>NC_022222.1|WP_020977542.1|2384976_2385576_-|DsbA-family-protein
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPYCKELDEKVMPKLRKNYIDNHKVEYQFVNLAFLGKDSIVSSRASHAVLMYAPKSFLDFQKQLFAAQQDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKDNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>NC_022222.1|WP_014532694.1|2394144_2394240_-|hypothetical-protein
MLTNRLTSVNYVKKRLIQNIQRILSKEVLYG
>NC_022222.1|WP_000792557.1|2394334_2395645_+|B-domain-containing-protein
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYTDKYFKYKGTIDKTVLSVFGNGYKSYIQPLKVEDQKNYVSKSYAQVRNYVTETLNTGKVLYAFYQNPNVVKAAITTAETAASIKNIFSSFTSFFK
>NC_022222.1|WP_000594519.1|2396136_2397066_+|bi-component-gamma-hemolysin-HlgAB-subunit-A
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>NC_022222.1|WP_020977544.1|2397632_2398580_+|bi-component-gamma-hemolysin-HlgCB-subunit-C
MLKNKILATTLSVGLLVPLANPLFENAKAANDTEDIGKGSDVEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKNTNHIKSMRWPFQYNIGLKTNDKNVSLINYLPKNKIETTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSINYTQQNYVSEVEQQNSKSVLWGVKANSFVTESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSGDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRIHNAFVNRNYTVKYEVNWKTHEIKVKGQN
>NC_022222.1|WP_020977545.1|2398581_2399559_+|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B
MKMNRLVKSSVATSMALLLLSNTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFEKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGRNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKLTVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>NC_022222.1|WP_020977546.1|2399610_2400078_-|QueT-transporter-family-protein
MISKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSVLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTLRKRMAVLLR
>NC_022222.1|WP_020977547.1|2400088_2400781_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKVNLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDDRIDLNHYISFLESTPKQVVYETV
>NC_022222.1|WP_020977548.1|2400791_2401907_-|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSSTTYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIPKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDVDRLFEILHQED
>NC_022222.1|WP_020977549.1|2401884_2402892_-|biotin-synthase-BioB
MNLAKHILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYGTCENKENKNDVSRAN
>NC_022222.1|WP_020977550.1|2402893_2404252_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGSSNIPSIELAEKLNEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGAVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMAAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYNAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRKLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRNCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC

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Crispr_ID: NC_022222_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022222_9

2667921-2668142

Orphan

Consensus_repeat	Method
TGAGTCAGATACNCTNGTTGAACC	CRT

4 spacers

The CRISPR arrays of NC_022222_9

>merge|NC_022222|9|2667921-2668142|CRT
TGAGTCAGATACACTCGTTGAACCAGATGTACTTAAGGAACTAGACGTACTCGATGAGTCAGATACGCTCGTTGAACCTGAACCTGACGTACTTAATGATTCGGATACGCTCGTTGAACCAGATGTACTTAAGGAACTAGACGTACTCGATGAGTCAGATACGCTTGTTGAACCTGAATTAGACGTACTCAATGATTCTGAGTCACTGATAGAAGTTGAATC

>NC_022222|9|1|2667921-2668142|CRT
TGAGTCAGATACACTCGTTGAACC	AGATGTACTTAAGGAACTAGACGTACTCGA
TGAGTCAGATACGCTCGTTGAACC	TGAACCTGACGTACTTAA
TGATTCGGATACGCTCGTTGAACC	AGATGTACTTAAGGAACTAGACGTACTCGA
TGAGTCAGATACGCTTGTTGAACC	TGAATTAGACGTACTCAATGATTC
TGAGTCACTGATAGAAGTTGAATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022222.1\|WP_001109867.1\|2674754_2675447_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NC_022222.1\|WP_020977644.1\|2662032_2662992_-\|accessory-Sec-system-protein-Asp3	unknown	unknown	gnl\|CDD\|163423
NC_022222.1\|WP_000916113.1\|2666091_2667303_-\|accessory-Sec-system-protein-translocase-subunit-SecY2	unknown	unknown	gnl\|CDD\|237095
NC_022222.1\|WP_020977642.1\|2658126_2659635_-\|accessory-Sec-system-glycosyltransferase-GtfA	unknown	unknown	gnl\|CDD\|131964
NC_022222.1\|WP_000244266.1\|2681555_2682056_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NC_022222.1\|WP_020977649.1\|2677716_2678367_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000185863.1\|2683054_2683747_-\|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl\|CDD\|349772
NC_022222.1\|WP_001236997.1\|2679524_2679809_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000603495.1\|2679958_2680318_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_001125620.1\|2651772_2653632_+\|amidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|236304
NC_022222.1\|WP_000593160.1\|2656775_2658134_-\|accessory-Sec-system-glycosylation-chaperone-GtfB	unknown	unknown	gnl\|CDD\|274351
NC_022222.1\|WP_020977645.1\|2662969_2664538_-\|accessory-Sec-system-protein-Asp2	unknown	unknown	gnl\|CDD\|274739
NC_022222.1\|WP_000565312.1\|2682290_2683058_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|226870
NC_022222.1\|WP_020977643.1\|2659652_2662043_-\|accessory-Sec-system-translocase-SecA2	unknown	unknown	gnl\|CDD\|163426
NC_022222.1\|WP_020977651.1\|2680402_2681014_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NC_022222.1\|WP_020977648.1\|2675760_2676714_+\|hypothetical-protein	unknown	unknown	unknown
NC_022222.1\|WP_000088195.1\|2653898_2654459_-\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238245
NC_022222.1\|WP_020977646.1\|2664527_2666081_-\|accessory-Sec-system-protein-Asp1	unknown	unknown	gnl\|CDD\|274740
NC_022222.1\|WP_020977641.1\|2654627_2656535_-\|cell-wall-anchored-protein-SasF	unknown	unknown	unknown
NC_022222.1\|WP_001228563.1\|2676785_2677730_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022222.1\|WP_001109867.1\|2674754_2675447_-\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	7.65588e-41
NC_022222.1\|WP_020977644.1\|2662032_2662992_-\|accessory-Sec-system-protein-Asp3	gnl\|CDD\|163423	TIGR03711, acc_sec_asp3, accessory Sec system protein Asp3. This protein is designated Asp3 because, along with SecY2, SecA2, and other proteins it is part of the accessory Sec system. The system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein family is assigned to transport rather than glycosylation function, but the specific molecular role is unknown. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	6.34696e-64
NC_022222.1\|WP_000916113.1\|2666091_2667303_-\|accessory-Sec-system-protein-translocase-subunit-SecY2	gnl\|CDD\|237095	PRK12417, secY, preprotein translocase subunit SecY; Reviewed.	4.31097e-176
NC_022222.1\|WP_020977642.1\|2658126_2659635_-\|accessory-Sec-system-glycosyltransferase-GtfA	gnl\|CDD\|131964	TIGR02918, lipopolysaccharide_biosynthesis_protein, accessory Sec system glycosylation protein GtfA. Members of this protein family are found only in Gram-positive bacteria of the Firmicutes lineage, including several species of Staphylococcus, Streptococcus, and Lactobacillus. Members are associated with glycosylation of serine-rich glycoproteins exported by the accessory Sec system. [Protein fate, Protein modification and repair].	0
NC_022222.1\|WP_000088195.1\|2653898_2654459_-\|cysteine-hydrolase	gnl\|CDD\|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	5.62235e-42
NC_022222.1\|WP_000565312.1\|2682290_2683058_-\|tyrosine-protein-phosphatase	gnl\|CDD\|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.88344e-144
NC_022222.1\|WP_001125620.1\|2651772_2653632_+\|amidase-domain-containing-protein	gnl\|CDD\|236304	PRK08581, PRK08581, amidase domain-containing protein.	0
NC_022222.1\|WP_000593160.1\|2656775_2658134_-\|accessory-Sec-system-glycosylation-chaperone-GtfB	gnl\|CDD\|274351	TIGR02919, conserved_hypothetical_protein, accessory Sec system glycosyltransferase GtfB. Members of this protein family are found only in Gram-positive bacteria of the Firmicutes lineage, including several species of Staphylococcus, Streptococcus, and Lactobacillus. [Protein fate, Protein modification and repair].	0
NC_022222.1\|WP_020977645.1\|2662969_2664538_-\|accessory-Sec-system-protein-Asp2	gnl\|CDD\|274739	TIGR03712, acc_sec_asp2, accessory Sec system protein Asp2. This protein is designated Asp2 because, along with SecY2, SecA2, and other proteins it is part of the accessory secretory protein system. The system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein family is assigned to transport rather than glycosylation function, but the specific molecular role is unknown. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0
NC_022222.1\|WP_000185863.1\|2683054_2683747_-\|polysaccharide-biosynthesis-tyrosine-autokinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	2.83977e-84
NC_022222.1\|WP_020977643.1\|2659652_2662043_-\|accessory-Sec-system-translocase-SecA2	gnl\|CDD\|163426	TIGR03714, Protein_translocase_subunit_SecA_2, accessory Sec system translocase SecA2. Members of this protein family are homologous to SecA and part of the accessory Sec system. This system, including both five core proteins for export and a variable number of proteins for glycosylation, operates in certain Gram-positive pathogens for the maturation and delivery of serine-rich glycoproteins such as the cell surface glycoprotein GspB in Streptococcus gordonii. [Protein fate, Protein and peptide secretion and trafficking].	0
NC_022222.1\|WP_000244266.1\|2681555_2682056_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.58707e-14
NC_022222.1\|WP_020977651.1\|2680402_2681014_-\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	2.38033e-45
NC_022222.1\|WP_020977646.1\|2664527_2666081_-\|accessory-Sec-system-protein-Asp1	gnl\|CDD\|274740	TIGR03713, acc_sec_asp1, accessory Sec system protein Asp1. This protein is designated Asp1 because, along with SecY2, SecA2, and other proteins it is part of the accessory secretory protein system. The system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein family is assigned to transport rather than glycosylation function, but the specific molecular role is unknown. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0

>NC_022222.1|WP_000916113.1|2666091_2667303_-|accessory-Sec-system-protein-translocase-subunit-SecY2
MLKLLQQYEYKIIYKRILYTCFILFIYILGTNISIVSYNDMQVKHESFFKIAISNMGGDVNTLNIFTLGLGPWLTSMIILMLISYRNMDKYMKQTSLEKHYKERILTLILSVIQSYFVIHEYVSKQRVHQDNIYLTILILVTGTMLLVWLADKNSRYGIAGPMPIVMVSIIKSMMHQKMEYIDASHIVIALLIILVIITLFILLFIELVEVRIPYIDLMNVSATNMKSYLSWKVNPAGSITLMMSISAFVFLKSGIHFILSIFNKSISDDMPMLTFDSPVGISVYLVIQMLLGYFLSRFLINTKQKSKDFLKSGNYFSGVKPGKDTERYLNYQARRVCWFGSALVTVIIGIPLYFTLFVPHLSTEIYFSVQLIVLVYISINIAETIRTYLYFDKYKPFLNQYW
>NC_022222.1|WP_020977646.1|2664527_2666081_-|accessory-Sec-system-protein-Asp1
MKYFIPAWYDDQRWWQDTTVPYYQLQNKTEFDDMISLMGMHLENDLDYQLIVLNHAPNIRTFLHRYDLYETKYWSVFDEIQGFSHHAPQAINYHHLKWPDDVEFVYTPYLLKCVTSEQTYTNIYFSQEGYSIWFEEFERDQLQRRYIFDDRGYLSAIRYFDNQGEASYQEYLTINGDCVLYENLKNGRVNVSKRYQHHYQQTEYNNMAQLIEEKFQAMIAQQIHEDDHMIVASDARHNRQIANHIPAKSLSYSFFKNRNETVSDEEYQSIVKNAHLIVDSVQLERDLISHQEKHQRENTMIRITPFETRQSPNISSQLMETFIGVWIDGMSDADLQQMMQRLVDYIVQEDNYRLILLTRHQNDIPLWLRECITSVNEEYQAKQNADVNVSALMTPEDQDDIIAVKTIHAEHDVVEALRTLRLVIDMSKEPDLYLQISAISAGIPQINGQQTDYVSDYDNGRIINTVDELDDALNYYLFYLKNWNYAYAYSLKLIDAYASKNIINQLDELIEGENDAT
>NC_022222.1|WP_020977645.1|2662969_2664538_-|accessory-Sec-system-protein-Asp2
MPRKFRVLQIGGDDLEPIFQHKKGVSWDYFDIGLFEFDSGYVEAIEAIVEAEGRFDFIYIQAPYSETLTNLLRMISEPYNTYVDESFWSVEYEQDENVQKYVVQPLHYRNIEERNNKLEAVSFSGQYGDKVSPKLALVHPNFKGDVVYQGNSELTLSGEFGKEFKPIASWQNNLVYDKDKVIQIWPEFDIDGAVELQYTFRLIQTGADGALIEQIILTDDMLDSPLEIPTKPFDAYISVTVKARGNGTVHLGPIHKRWSRLDMGQFLLGGSRFVDSQRQEFIYYFHPGDMKPPLNVYFSGYRTAEGFEGYYMMKRMNAPFLLIGDPRVEGGSFYIGSSEYEQGIINVIDETLEKLNFKSHELILSGLSMGSFGALYYGAQLNPQAIIVGKPLVNIGTIAEHMRLLRPEEFGTALDVLVSNEGDTSQASIQALNQKFWQTCQKKSLSQTVFAIAYMQHDDYDPHAFQELLPVLTAHQARVMNRSIPGRHNDDSPTIASWFVNFYNIILEDKFGRVQHAEKQNI
>NC_022222.1|WP_020977644.1|2662032_2662992_-|accessory-Sec-system-protein-Asp3
MLKNKTFKVTWNYISQTTFMYGSKVSFSNGEVTFINPLMPSGLPIHEWLMLKQFSKYKSAPSLPILRRGQHYKLHFDFDATPAGSVYFIIIFYNKNGTKLSTEIVKSNSITIQYPDEVYAYKIKMMNAASTSLIFRCLTITEMTHQDDLEYKSMRVTKIGDDQYGNDRINVIIAEPSDAYPTISNDFLKPFGHVWLVERWMDDNIEENIKQLKNDLQSQDTIKAINLISYGSKSNVFATYVAQHLDCKVYRTSHEDDDLKDWFKEHVPGNHELKDTNVEVYFKEEQDNHLNYMSRLMNPVRFLDYLDVSKLNGGEVNET
>NC_022222.1|WP_020977643.1|2659652_2662043_-|accessory-Sec-system-translocase-SecA2
MKHKLDVTINELRLKSIRKIVKRINTWSDEVKSYSDDALKQKTIEFKERLALGVDTLDTLLPEAYAVAREASWRVLGMYPKEVQLIGAIVLHEGNIAEMQTGEGKTLTATMPLYLNALSGKGTYLITTNDYLAKRDFEEMQPLYEWLGLTSSLGFVDIVDYEYQKGEKRNIYEHDIIYTTNGRLGFDYLIDNLADSAEGKFLPQLNYGIIDEVDSIILDAAQTPLVISGAPRLQSNLFHIVKEFVDTLIEDVHFKMKKTKKEIWLLNQGIEAAQSYFNVEDLYSEQAMVLVRNINLALRAQYLFESNVDYFVYNGDIVLIDRITGRMLPGTKLQAGLHQAIEAKEGMEVSTDKSVMATITFQNLFKLFGSFSGMTATGKLGESEFFDLYSKIVVQVPTDKAIQRIDEPDKVFRSVDEKNIAMIHDIVELHETGRPVLLITRTAEAAEYFSKVLFQMDIPNNLLIAQNVAKEAQMIAEAGQIGSMTVATSMAGRGTDIKLGEGVEALGGLAVIIHEHMENSRVDRQLRGRSGRQGDPGSSCIYISLDDYLVKRWSDSNLAENNQLYSLDAQRLSQSSLFNRKVKQIVVKAQRISEEQGVKAREMANEFEKSISIQRDLVYEERNRVLEIDDAENRDFKALAKDVFEMFVNEEKVLTKSRVVEYIYQNLSFQFNKDVACVNFKDKQAVVTFLLEQFEKQVALNRKNMQSAYYYNIFVQKVFLKAIDSCWLEQVDYLQQLKASVNQRQNGQRNAIFEYHRVALDSFEVMTRNIKKRMVKNICQSMITFDKEGMPVIHFP
>NC_022222.1|WP_020977642.1|2658126_2659635_-|accessory-Sec-system-glycosyltransferase-GtfA
MTIYNINFGIGWASSGVEYAQAYRAKLLRRTNQDTKFVFLDFIQSENIQTLTQNIGFEDQEVIWLYQYFSDISIAPTTYTLDDIERDLGHDISFRERNGKIVRLYFNGKSSFVTCYLQNEQKDIVDRAEFVINSMLVRKDFYSYTRIFSEYYAPADNKAKLYMRQFYNEDGSIAYNEYIDGDSSIYVFADAVLYNKTEFIAYFLQRLNLTRDDIVILDRASDIGQAVLQHKGDSKVGVVIHADHYSNNMMSEQHILWNNYYEYQFSKAKYIDFFITATDIQNHMVCRQFEQYQGYRPRVYTIPVGSIDALSYPTLSRKPYAMISASRLANEKHIDWLVKAVIVAKRQVPKLTFDIYGEGSEKTRLRKIIDTHRAQDYIRLLGHVKLDEIYTDYELFLSASTSEGFGLTLMEAVGSGLGMIGLNVNYGNPTFIRDGENGYLVPFDTDEDSVDDVVAKLAHAIVMYFNDGPQTPHDISYEVAQQFMTQDIILKWETLVQEVLYD
>NC_022222.1|WP_000593160.1|2656775_2658134_-|accessory-Sec-system-glycosylation-chaperone-GtfB
MIKLFDYFNDHSRKLYESFKASKLEEDLTIVLNDNGFLPDDVISPYQFFADNHNTENMKPRFFNQVTVPAFWEIKGNNNSATINDMGRLRGKIFYQSGERPRIVSRVEWFDDQQRVRFVDYYSKNGIKFAQTVYDLNRKAILKKYMTAEGKEVIYENFVTSDVILDWQGKSYFFPSKLAFVLFFIKQLEITEHHFVINSLALPFSVLYNLPSNGSDVLVWQEQCDGNVPGNMQLMCKGDMKRHCNIIIPDKNEYETMLNIADAKVQSRILQGGYLYNYRSRNRYTKEIVILTNSDQLRNIKVLVETLPDFKFHIAAITEMSDKLMQLDQYANVHLYPSINIDRVNELYQLCDIYLDINEGNEILNAVEQAFDYELLILGYRQTAHHAKVTLSEHLFEHNDEITMESKDQLIQMLESLKDQQQFRDALLAQKAHAHEISREQFEQVFKQALES
>NC_022222.1|WP_020977641.1|2654627_2656535_-|cell-wall-anchored-protein-SasF
MAKYRGKPFQLYVKLSCSTMMATSIILTNILPYDAQAASENDTEISKEILSKQDLLDKVDKANRQIEQLKQLSASSKAHYKAQLNEAKTASQIDEIIKRANELDSKDNKGSQIEMNGQSDIDSKLDQLLKDLNEVSSKVDSGQQSGEDDLNAMKNDMSQTATTKHGEKDDKNDEAMVDKALEDLDHLNQQIHKSKDASKDTSENPAVSTTDNNHEVAKTPNNDGSGHVVLNKFLSNEENQSHSNRLTDKLQGSDKINHAMIEKLAKSNASTHHYTYHKLNTLQSLDQRIANTQLPKNQKSDLMSEVNKTKERIKSQRNIILEELARTDDKKHATQNILESIFNKDEADKILKDIRVDGKTDQQIADQITRHIDQLSLTTSDDLLTSLIDQSQDKSLLISQILQTKLGKSEADKLAKDWTNKGLSNRQIVDQLKKHFASTGDTSSDDILKAILNNAKDKKQAIETILATRIERQKAKLLADLITKIETDQNKIFNLVKSALNGKADDLLNLQKRLNQTKKDIDYVLSPIVNRPSLLDRLNKNGKTTDLNKLASLMNQGSNLLDSIPDIPTPKPEKTLTLGKGNGLLSGLLNADGNVSLPKAGETIKEHWLPISVIVGAMGVLMIWLSRRNKLKNKA
>NC_022222.1|WP_000088195.1|2653898_2654459_-|cysteine-hydrolase
MSRKTALLVLDMQEGIASSVPRIKNIIKANQRAIEAARQHRIPVIFIRLVLDKHFNDVSSSNKVFSTIKAQGYAITEADASTRILEDLAPLEDEPIISKRRFSAFTGSYLEVYLRANDINHLVLTGVSTSGAVLSTALESVDKDYYITVLEDAVGDRSDDKHDFIIEQILSRSCDIESVESWKSSL
>NC_022222.1|WP_001125620.1|2651772_2653632_+|amidase-domain-containing-protein
MPKNKILIYLLSTTLVLPTLVSPTAYADTPQKDTTAKTTSHDSKKSNDDETSKDTTSKDIDKADNNNTSNQDNNDKKFKTIDDSTSDSNNIIDFIYKNLPQTNINQLLTKNKYDDNYSLTTLIQNLFNLNSDISDYEQPRNGEKSTNDSNKNSDNSIKNDTDTQSSKQDKADNQKAPKSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDKANQKSSSKDNQSMSDSALDSILDQYSEDAKKTQKDYASQSKKDKNEKSNTKNPQLPTQDELKHKSKPAQSFNNDVNQKDTRATSLFETDPSISNNDDSGQFNVVDSKDTRQFVKSIAKDAHRIGQDNDIYASVMIAQAILESDSGRSALAKSPNHNLFGIKGAFEGNSVPFNTLEADGNQLYSINAGFRKYPSTKESLKDYSDLIKNGIDGNRTIYKPTWKSEADSYKDATSHLSKTYATDPNYAKKLNSIIKHYQLTQFDDERMPDLDKYERSIKDYDDSSDEFKPFREVSDSMPYPHGQCTWYVYNRMKQFGTSISGDLGDAHNWNNRAQYRDYQVSHTPKRHAAVVFEAGQFGADQHYGHVAFVEKVNSDGSIVISESNVKGLGIISHRTINASAAEELSYITGK
>NC_022222.1|WP_001109867.1|2674754_2675447_-|flavin-reductase-family-protein
MNYSPKQGVRSHGLPHDPFKSSTVPRPIGWISTISKDGKDNLAPYSQYQNLTWDPPMVMFAANQSVLGDHERKDTVKNAEETGWFVWNMATYDLREAVNLSSKALPPEEDEFEYAGVTKEACIEAPGYRVKESPVHFECEYVQTIRIPTGDPVSTVDIVIGRVAQVHIDDKVILDNGKLDIKSIKPIARLGYYDYTVVNEIFEMKAPSASKEELAGLEGRNFDNQSDNKK
>NC_022222.1|WP_020977648.1|2675760_2676714_+|hypothetical-protein
MRKIMRILLCTSIIVSGCSFIPKNQTKDMPKTVSVKDYDGQYIGEHKKRNEVFLKKHKDEAIKKYKDYVKDTFGYDCKINLVEAYTNKSGFSEKSKTDGLVVVGTVNYDVPFQLQLIFVESDNGVAITTFTPGHINETSAAVSAMMYKRYEHEIEEARLKFKSEVEKNGYYTMNEKLQKKQEFNGVTKQFLNFNTDSIDDLDKFKKEFKPVMHLKGDAFNQQLQNLINKYPEIKKSMKSDFIAYYDKKSTKNVNKYSWDLQIPTNDTMKKIPGSKMMYFYKDSVSPSEIGEDGKLENKTNKITMSGGNWEEIQKEIK
>NC_022222.1|WP_001228563.1|2676785_2677730_+|hypothetical-protein
MRKLIGFILCTSIIVSGCSCIPKYHTKNIPKTVSVKDYDGKYIGEHKKRNEVFLKKHKDEAIKKYKNYVKDTFGYDCKINLVEAYTNKSGFSEKSKTDGLVVVGTVNYDVPFQFRLIFVESDNGITITTFTPGHKNETSAAVAAMMYKRYEHDIEQARLKFKSEVEKNGYYAMNEKLQKKQEFNGVTKQYLNFNTVSIDDLDKFKKEFKPVMHLKGDAFNQQLQSLINKYPQIQKNMKSEFIGYYDKDANKETVADYAWSLKKPTNEIMKTYPGEKRMRFYKDKVSPYELDQYGRLNPDADEIYVIGGNYNEKK
>NC_022222.1|WP_020977649.1|2677716_2678367_+|hypothetical-protein
MRKNDHITDLDAIELSSGWNYNDKITLSDEIHVNGNKYKVIKDQKPTNTGLGYKLYERYDNDRSTGKLIISFDGTDFSDPNDVGTDLRLAGDSIPNQLEEAHKVYSDLKQKYSDASSLSDIEFYNKYKEESIDYKGKSITNAGGNSLSGAIAQYLGVLDPGLNVTTTNSAPIPKSLTRMARRDANNIHNYHSRSDTLTRINIVDLCIIPWSESTFS
>NC_022222.1|WP_001236997.1|2679524_2679809_+|hypothetical-protein
MRLILGELIFTEFVIVEMQDFFKNALLSDSLLRDIKVLSSNAKGDADMLETELHAVINAMSQNEGKSVDALKNSTASLKNNLTKLKEQLDKTTH
>NC_022222.1|WP_000603495.1|2679958_2680318_+|hypothetical-protein
MILRYVTNLKLAKELYQASKPKLQEDKGMIELFEHTFGLQKELVKYVGIAEATTAALYSASFINKNISRLASLSTIGILSVAAYKHFEAGHGKKGAQHALDLLGLATLSLLDTFSCNKK
>NC_022222.1|WP_020977651.1|2680402_2681014_-|flavin-reductase-family-protein
MYTFDAQSLTARENYKLLIGSIIPRPIAFVTTLNQDASVNAAPFSFFNIVNNHPPMIAIAVQRAGGKRKDTALNIERTGDFVVHITDEDNVQDINETAAPLAYGDSELSRTELSLLTSTTIKTPGIKDAKMRFECKLSQMILLGDVLDGADLIIGEIVTYHIDDSIYEGNFKINPHALQAVSRLAGNDYAKLGGIFTIKRPEK
>NC_022222.1|WP_000244266.1|2681555_2682056_-|GNAT-family-N-acetyltransferase
MVLRKVIMQDLDQIIALENIGFSPEEAATPEALKLRIEQIQETFIVAEKNDEVIGYINGPVIKERYISDDLFKNVPTNNSEGGYISVLGLVVAPNYQGQGIAGRLLNYFENLAKNQHRHGVTLTCRESLISFYEKYGYRNEGVSESCHGGIKWYNLVKNIKKDDEV
>NC_022222.1|WP_000565312.1|2682290_2683058_-|tyrosine-protein-phosphatase
MIDIHNHILVDIDDGPKTIEKSIALLKQAKDEGVTSIVATPHHLHPRYDNTFQQVLVKLAELRTHPEVQALDIKLFPGQEIRITDSILQGLDNGSIQGINRSKYLLIEFPTGEVPHYTKQLFFEIQSRGYIPIIAHPERNRSIAKNPEILYELVANGALSQLTSSSLVGGFGKNIQKLSLQFIECNLAHFVASDAHSCDQRPFLMQELFHNHKLKKYSNDIEALLRNASSVINDNFVYLDRPTKPGKVKSFLKWF
>NC_022222.1|WP_000185863.1|2683054_2683747_-|polysaccharide-biosynthesis-tyrosine-autokinase
MTNTRRSTSSLIVHEQPKSPISEKFRGIRSNIMFANPDSAVQSIVITSEAPGAGKSTIAANLAVAYAQAGYKTLIVDGDMRKPTQHYIFNLPNNEGLSSLLLNWSTYQDSIISTEIQDLDVLTSGPIPPNPSELITSRAFANLYDTLLMNYNFVIIDTPPVNTVTDAQLFSKFTGNVVYVVNSENNNKDEVKKGKELIEATGAKLLGVVLNRMPKDKSASYYAYYGTDES

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Crispr_ID: NC_022222_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022222_10

2729866-2729951

Orphan

Consensus_repeat	Method
CCAACTTGCACATTATTGTAAGCTGACTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022222_10

>merge|NC_022222|10|2729866-2729951|CRISPRCasFinder
CCAACTTGCACATTATTGTAAGCTGACTTTCCGCCAGCTTCTATGTTGGGGCCCCGCCAACTTGCACATTATTGTAAGCTGACTTT

>NC_022222|10|8|2729866-2729951|CRISPRCasFinder
CCAACTTGCACATTATTGTAAGCTGACTTT	CCGCCAGCTTCTATGTTGGGGCCCCG
CCAACTTGCACATTATTGTAAGCTGACTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022222.1\|WP_000491384.1\|2729288_2729642_-\|DUF3147-family-protein	unknown	unknown	gnl\|CDD\|288237
NC_022222.1\|WP_000672036.1\|2727056_2727248_+\|peptide-resistance-ABC-transporter-activity-modulator-VraH	unknown	unknown	unknown
NC_022222.1\|WP_000410770.1\|2721782_2722295_-\|HdeD-family-acid-resistance-protein	unknown	unknown	gnl\|CDD\|225786
NC_022222.1\|WP_020977679.1\|2733796_2735176_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NC_022222.1\|WP_001813111.1\|2735319_2735673_-\|ribonuclease-P-protein-component	unknown	unknown	gnl\|CDD\|234782
NC_022222.1\|WP_020977677.1\|2728786_2729221_-\|DUF3147-family-protein	unknown	unknown	gnl\|CDD\|288237
NC_022222.1\|WP_000240855.1\|2735792_2735930_-\|50S-ribosomal-protein-L34	unknown	unknown	gnl\|CDD\|366117
NC_022222.1\|WP_000215588.1\|2731133_2731853_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NC_022222.1\|WP_001054113.1\|2727966_2728536_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_022222.1\|WP_020977678.1\|2731852_2733730_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	unknown	unknown	gnl\|CDD\|235362
NC_022222.1\|WP_001059079.1\|2727639_2727840_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NC_022222.1\|WP_000742837.1\|2730251_2731091_-\|nucleoid-occlusion-protein	unknown	unknown	gnl\|CDD\|275105
NC_022222.1\|WP_020977675.1\|2725304_2725496_+\|peptide-resistance-ABC-transporter-activity-modulator-VraH	unknown	unknown	unknown
NC_022222.1\|WP_020977674.1\|2723332_2725213_+\|peptide-resistance-ABC-transporter-permease-subunit-VraE	unknown	unknown	gnl\|CDD\|376899
NC_022222.1\|WP_000154162.1\|2722584_2723343_+\|peptide-resistance-ABC-transporter-ATP-binding-subunit-VraD	unknown	unknown	gnl\|CDD\|224059
NC_022222.1\|WP_000586238.1\|2726102_2726600_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022222.1\|WP_000491384.1\|2729288_2729642_-\|DUF3147-family-protein	gnl\|CDD\|288237	pfam11345, DUF3147, Protein of unknown function (DUF3147). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	1.88155e-38
NC_022222.1\|WP_020977678.1\|2731852_2733730_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	gnl\|CDD\|235362	PRK05192, PRK05192, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG.	0
NC_022222.1\|WP_000410770.1\|2721782_2722295_-\|HdeD-family-acid-resistance-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	3.26175e-22
NC_022222.1\|WP_020977679.1\|2733796_2735176_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NC_022222.1\|WP_001813111.1\|2735319_2735673_-\|ribonuclease-P-protein-component	gnl\|CDD\|234782	PRK00499, rnpA, ribonuclease P; Reviewed.	1.78992e-51
NC_022222.1\|WP_020977677.1\|2728786_2729221_-\|DUF3147-family-protein	gnl\|CDD\|288237	pfam11345, DUF3147, Protein of unknown function (DUF3147). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	1.75949e-42
NC_022222.1\|WP_000240855.1\|2735792_2735930_-\|50S-ribosomal-protein-L34	gnl\|CDD\|366117	pfam00468, Ribosomal_L34, Ribosomal protein L34.	8.39798e-10
NC_022222.1\|WP_001054113.1\|2727966_2728536_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.31105e-16
NC_022222.1\|WP_001059079.1\|2727639_2727840_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.4289e-30
NC_022222.1\|WP_000742837.1\|2730251_2731091_-\|nucleoid-occlusion-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	1.327e-113
NC_022222.1\|WP_000215588.1\|2731133_2731853_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	3.12556e-96
NC_022222.1\|WP_020977674.1\|2723332_2725213_+\|peptide-resistance-ABC-transporter-permease-subunit-VraE	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	2.75002e-06
NC_022222.1\|WP_000154162.1\|2722584_2723343_+\|peptide-resistance-ABC-transporter-ATP-binding-subunit-VraD	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	3.13228e-111

>NC_022222.1|WP_000491384.1|2729288_2729642_-|DUF3147-family-protein
MFSIGSAILHFVIGGIAVALASIIADKVGGKLGGIIATMPAVFLAAIIALALDHRGTQLVEMSMNLSTGAIVGILSCILTVFLTSLYINHKGYRKGAIFTVVCWFVISLAIFSIRHL
>NC_022222.1|WP_020977677.1|2728786_2729221_-|DUF3147-family-protein
MKLTLMKFFVGGFAVLLSYIVSVTLPWKEFGGIFATFPAVFLVSMFITGMQYGDKVAVHVSRGAVFGMTGVLVCILVTWMMLHMTHMWLISIIVGFLSWFISAVCIFEAVEFIAQKRLEKHSWKAGKSNSKYCERNLLNRTNSK
>NC_022222.1|WP_001054113.1|2727966_2728536_-|helix-turn-helix-transcriptional-regulator
MNLSKQIKKYRERDGYSQEYLAEKLYVSRQSISNWENDKSLPDIHNLLMMCELFNVTLDDLVKGTIPFVPDIKAQRSLNLWTYVMLIFMALAAILMGPLVVYWNWTWGITVAIIMGIGFYASMKIEDLKKVHKMDNYDRIVAFMNGKDPSEVQTTKARNTMTNALSIISVVGTLSLIIFLSVYLANKFL
>NC_022222.1|WP_001059079.1|2727639_2727840_+|cold-shock-protein
MNNGTVKWFNAEKGFGFIEQENGGDVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV
>NC_022222.1|WP_000672036.1|2727056_2727248_+|peptide-resistance-ABC-transporter-activity-modulator-VraH
MKFRELVKQSYEDLKNLTVTWYNVIALAMIVIVLSVVTTPIIGIPVGLLGGAYYLKRREEKGK
>NC_022222.1|WP_000586238.1|2726102_2726600_-|hypothetical-protein
MIINLETQQIHFDLEHETPYFQSPEKNRIRLDIDVLNKKQISNIINVIFNNQSKTKCTFLSEYLYPVKFREKTRIGRFFNITNWYEEIHSTDEKYVIATIKNIKNKDLIDYSLYIKKGLVEPFIVFYNQENIFYISNTVIDIISVSKDTLGYIKSEFNDHCASPY
>NC_022222.1|WP_020977675.1|2725304_2725496_+|peptide-resistance-ABC-transporter-activity-modulator-VraH
MQFRELVKQSYEDLKNLTVTWYNVIALAMIVIVLSSVTTPIIGIPAGLLGGAYYLKRREEKGK
>NC_022222.1|WP_020977674.1|2723332_2725213_+|peptide-resistance-ABC-transporter-permease-subunit-VraE
MTFNHIVFKNLRQNLKHYAMYLFSLFFSIVLYFSFTTLQFTKGVNNDDSMAIIKKGALVGSIFLFIIIVIFLMYANHLFVKRRTREFALFQLIGLTRQNILKMLALEQMIVFLITGVVGVLCGIAGAQLLLSIVSKLMSLSINLSIHFEPMALVLTILMLIIAYILILFQSSLFLKRRSILSMMKDSIKTDVTTAKVTTAEVISGVLGIAMIALGYYMATEMFGTFKALTMAMTSPFIILFLTVVGAYLFFRSSVSLIFKTLKKSKNGRVSITDVVFTSSIMYRMKKNAMSLTIIAIISAVTVTVLCFAALSKSNTDQTLTSMAPNDFNVVASQDAQQFESKLSQQHITFFKNAYETITVNNVKDEVITLENGSDSGRTNSILSANTKLTGNNAIIANTKSLPNIINIHLNKDLVVKGTKNETFRVTQEDKGKVYPLNLSFNSPVVEVSPEKYQQLKTQNNVHTFYGYDIKQTSQKEKAQAIAKQFGDKVITYDDMKKEVDATNGILIFVTSFLGLAFLVAAGCIIYIKQMDETEDELSNFRILKRIGFTHTDMLKGLLLKITFNFGLPLLIAILHAVFAAIAFMKLMGNISFMPVIIVIVVYTLIYIAFALIAFLHSNKLIKKTI
>NC_022222.1|WP_000154162.1|2722584_2723343_+|peptide-resistance-ABC-transporter-ATP-binding-subunit-VraD
MTILSVQHVSKTYGKKHTFQALKDINFDIQKGEFVAIMGPSGSGKTTLLNVLSSIDQISSGSVIANGQELNKLNQKALAKFRKESLGFIFQDYSILPTLTVKENIMLPLSVQKMSKATMEENYKAITTALGIYDLGNKYPSELSGGQQQRTAAARAFVHKPQIIFADEPTGALDSKSANDLLQRLEEMNKSFDTTIVMVTHDPVAASFAERVIMLKDGQIHTQLYQEGRSKQAFYEDIVHLQSVLGGVSNDI
>NC_022222.1|WP_000410770.1|2721782_2722295_-|HdeD-family-acid-resistance-protein
MEKGNQGIKWSSLIMGVLLLMLAVVIFTFPIENFYAITWLIGLFVLINGVIQIVYRRKAKALVGGNQNWILFMGIVDILFGLIVIFNVGASSAFFIYMFAFWFIFSSIAGLFTFSGSGSLKLISVIFNLLGIVFGVILLFNPLMGIVFISTMIAIAFVFVGVIYVVDALA
>NC_022222.1|WP_000742837.1|2730251_2731091_-|nucleoid-occlusion-protein
MKKPFSKLFGLKNKDDIIGHIEEDRNSNVESIQIERIVPNRYQPRQVFEPNKIKELAESIHEHGLLQPIVVRPIEEDMFEIIAGERRFRAIQSLNLPQADVIIRDMDDEETAVVALIENIQRENLSVVEEAEAYKKLLEIGDTTQSELAKSLGKSQSFIANKLRLLKLAPKVLLRLREGKITERHARAVLSLSDSEQEALIEQVIAQKLNVKQTEDRVRQKTGPEKVKAQNLRFAQDVTQARDEVGKSIQAIQQTGLHVEHKDKDHEDYYEIKIRIYKR
>NC_022222.1|WP_000215588.1|2731133_2731853_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MTVEWLAEQLKEHNIELTETQKQQFQTYYRLLVEWNEKMNLTSITDEHDVYLKHFYDSIAPSFYFDFNQPISICDVGAGAGFPSIPLKIMFPQLKVTIVDSLNKRIQFLNHLASELQLQDVSFIHDRAETFGKGVYRESYDVVTARAVARLSVLSELCLPLVKKGGQFVALKSSKGEEELEEAKFAISVLGGNVTETHTFELPEDAGERQMFIIDKKRQTPKKYPRKPGTPNKTPLLEK
>NC_022222.1|WP_020977678.1|2731852_2733730_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG
MAQEYDVIVIGAGHAGVEAGLASARRGAKTLMLTINLDNIAFMPCNPSVGGPAKGIVVREIDALGGQMAKTIDKTHIQMRMLNTGKGPAVRALRAQADKVLYQQEMKRVIEDEENLHIMQGMVDELIIEDNEVKGVRTNIGTEYLSKAVIITTGTFLRGEIILGNMKYSSGPNHQLPSITLSDNLRELGFDIVRFKTGTPPRVNSKTIDYSKTEIQPGDDVGRAFSFETTEYILDQLPCWLTYTNAETHKVIDDNLHLSAMYSGMIKGTGPRYCPSIEDKFVRFNDKPRHQLFLEPEGRNTNEVYVQGLSTSLPEHVQRQMLETIPGLEKADMMRAGYAIEYDAIVPTQLWPTLETKMIKNLYTAGQINGTSGYEEAAGQGLMAGINAAGKVLNAGEKILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTDMGYELGMISEERYARFNEKRQQIDAEIKRLSDIRIKPNEHTQAIIEQHGGSRLKDGILAIDLLRRPEMTYDIILEILEEEHQLNADVEEQVEIQTKYEGYINKSLQQVEKVKRMEEKKIPEDLDYSKIDSLATEAREKLSEVKPLNIAQASRISGVNPADISILLIYLEQGKLQRVSD
>NC_022222.1|WP_020977679.1|2733796_2735176_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MDLDTITSISTPMGEGAIGIVRLSGPQAVEIADKLYKGKHLLNDVPSHTINYGHIIDPESKEVVEEVMVSVLRAPKTFTREDIIEINCHGGILTINRVLELTMTYGARMADPGEFTKRAFLNGRIDLSQAEAVMDFIRSKTDRASKVAMNQIEGRLSDLIKKQRQSILEILAQVEVNIDYPEYDDVEDATTEFLLEQSKEIKQEINRLLDTGAQGKIMREGLSTVIVGKPNVGKSSMLNNLIQDNKAIVTEVAGTTRDVLEEYVNVRGVPLRLVDTAGIRETEDIVEKIGVERSRKALSQADLILFVLNNNEALTQEDYTLYEVVKNEDVIVIVNKMDLEQNIDINEVKDMIGDTPLIQTSMLKQEGIDELEIQIRDLFFGGEVQNQDMTYVSNSRHISLLKQARQTIQDAIDAAESGVPMDMVQIDLTRTWEILGEIIGETASDELIDQLFSQFCLGK
>NC_022222.1|WP_001813111.1|2735319_2735673_-|ribonuclease-P-protein-component
MLLEKSYRIKKNADFQRIYKKGHSVANRQFVVYTCNNKEIDHFRLGISVSKKLGNAVLRNKIKRAIRENFKVHKSHILAKDIIVIARQPAKDMTTLQIQNSLEHVLKIAKVFNKKIK
>NC_022222.1|WP_000240855.1|2735792_2735930_-|50S-ribosomal-protein-L34
MVKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLSA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022222_10	10.1\|2729896\|26\|NC_022222\|CRISPRCasFinder	2729896-2729921	26	NC_022222.1	1257068-1257093	0	1.0
NC_022222_10	10.1\|2729896\|26\|NC_022222\|CRISPRCasFinder	2729896-2729921	26	NC_022222.1	2273185-2273210	0	1.0
NC_022222_10	10.1\|2729896\|26\|NC_022222\|CRISPRCasFinder	2729896-2729921	26	NC_022222.1	1960641-1960666	1	0.962
NC_022222_10	10.1\|2729896\|26\|NC_022222\|CRISPRCasFinder	2729896-2729921	26	NC_022222.1	2380278-2380303	1	0.962
NC_022222_9	9.2\|2667999\|18\|NC_022222\|CRT	2667999-2668016	18	NC_022222.1	996953-996970	2	0.889
NC_022222_10	10.1\|2729896\|26\|NC_022222\|CRISPRCasFinder	2729896-2729921	26	NC_022222.1	796715-796740	2	0.923
NC_022222_10	10.1\|2729896\|26\|NC_022222\|CRISPRCasFinder	2729896-2729921	26	NC_022222.1	1602232-1602257	2	0.923

1. spacer 10.1|2729896|26|NC_022222|CRISPRCasFinder matches to position: 1257068-1257093, mismatch: 0, identity: 1.0

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgccagcttctatgttggggccccg	Protospacer
**************************

2. spacer 10.1|2729896|26|NC_022222|CRISPRCasFinder matches to position: 2273185-2273210, mismatch: 0, identity: 1.0

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgccagcttctatgttggggccccg	Protospacer
**************************

3. spacer 10.1|2729896|26|NC_022222|CRISPRCasFinder matches to position: 1960641-1960666, mismatch: 1, identity: 0.962

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgacagcttctatgttggggccccg	Protospacer
*** **********************

4. spacer 10.1|2729896|26|NC_022222|CRISPRCasFinder matches to position: 2380278-2380303, mismatch: 1, identity: 0.962

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgccagcttctgtgttggggccccg	Protospacer
************.*************

5. spacer 9.2|2667999|18|NC_022222|CRT matches to position: 996953-996970, mismatch: 2, identity: 0.889

tgaacctgacgtacttaa	CRISPR spacer
tgtacctgacgtacataa	Protospacer
** *********** ***

6. spacer 10.1|2729896|26|NC_022222|CRISPRCasFinder matches to position: 796715-796740, mismatch: 2, identity: 0.923

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgtcagcttttatgttggggccccg	Protospacer
***.******.***************

7. spacer 10.1|2729896|26|NC_022222|CRISPRCasFinder matches to position: 1602232-1602257, mismatch: 2, identity: 0.923

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgtcagcttctgtgttggggccccg	Protospacer
***.********.*************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	HQ698922	Acinetobacter phage ZZ1, complete genome	27553-27584	7	0.781
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	MK240351	Acinetobacter phage Henu6, complete genome	85825-85856	7	0.781
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NZ_CP004876	Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB299, complete sequence	87113-87144	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NC_017203	Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281, complete sequence	124272-124303	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NC_020384	Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-285, complete sequence	128495-128526	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NZ_CP010578	Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB232, complete sequence	100496-100527	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NZ_CP011350	Bacillus thuringiensis strain YC-10 plasmid pYC1, complete sequence	439360-439391	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NZ_CP011350	Bacillus thuringiensis strain YC-10 plasmid pYC1, complete sequence	758850-758881	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NZ_CP015152	Bacillus thuringiensis strain Bc601 plasmid pBTBC2, complete sequence	124161-124192	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NZ_CP013056	Bacillus thuringiensis strain YWC2-8 plasmid pYWC2-8-1, complete sequence	78421-78452	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NZ_CP004861	Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB293, complete sequence	86845-86876	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NZ_AP014866	Bacillus thuringiensis serovar tolworthi strain Pasteur Institute Standard strain plasmid pKK2, complete sequence	58534-58565	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NZ_CP014853	Bacillus thuringiensis strain HD12 plasmid pHD120345, complete sequence	333612-333643	8	0.75
NC_022222_5	5.1\|1602154\|32\|NC_022222\|CRISPRCasFinder	1602154-1602185	32	NZ_CP010091	Bacillus thuringiensis serovar galleriae strain 4G5 plasmid pBMB267, complete sequence	81118-81149	8	0.75

1. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to HQ698922 (Acinetobacter phage ZZ1, complete genome) position: , mismatch: 7, identity: 0.781

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
ttgcttgttgaattgctttaccaactgcgcgt	Protospacer
****.********* ********* * * *

2. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to MK240351 (Acinetobacter phage Henu6, complete genome) position: , mismatch: 7, identity: 0.781

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
ttgcttgttgaattgctttaccaactgcgcgt	Protospacer
****.********* ********* * * *

3. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NZ_CP004876 (Bacillus thuringiensis serovar kurstaki str. HD-1 plasmid pBMB299, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

4. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NC_017203 (Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

5. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NC_020384 (Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-285, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

6. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NZ_CP010578 (Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 plasmid pBMB232, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

7. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NZ_CP011350 (Bacillus thuringiensis strain YC-10 plasmid pYC1, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

8. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NZ_CP011350 (Bacillus thuringiensis strain YC-10 plasmid pYC1, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

9. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NZ_CP015152 (Bacillus thuringiensis strain Bc601 plasmid pBTBC2, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

10. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NZ_CP013056 (Bacillus thuringiensis strain YWC2-8 plasmid pYWC2-8-1, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

11. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NZ_CP004861 (Bacillus thuringiensis serovar kurstaki str. YBT-1520 plasmid pBMB293, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

12. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NZ_AP014866 (Bacillus thuringiensis serovar tolworthi strain Pasteur Institute Standard strain plasmid pKK2, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

13. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NZ_CP014853 (Bacillus thuringiensis strain HD12 plasmid pHD120345, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

14. spacer 5.1|1602154|32|NC_022222|CRISPRCasFinder matches to NZ_CP010091 (Bacillus thuringiensis serovar galleriae strain 4G5 plasmid pBMB267, complete sequence) position: , mismatch: 8, identity: 0.75

ttgcctgttgaatttctttaccaaattctctg	CRISPR spacer
tcttttcttcaatttcattaccaaattctcta	Protospacer
*. ..* ** ****** **************.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

614647 : 674892

Staphylococcus_phage(75.0%)

tail,integrase,tRNA,transposase,holin

attL 613536:613551|attR 634832:634847

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
613536:613551	attL	NA	NA	NA	NA
WP_020977035.1\|614647_616309_+\|tRNA	arginine--tRNA ligase	NA	NA	NA	NA
WP_000901752.1\|616505_617141_+	endonuclease III domain-containing protein	NA	NA	NA	NA
WP_000749048.1\|617329_618217_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_020977036.1\|618367_619318_+	iron ABC transporter permease	NA	NA	NA	NA
WP_000365354.1\|619372_620092_+	HAD family hydrolase	NA	NA	NA	NA
WP_000362960.1\|620075_620876_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_000735554.1\|621011_621518_+	hypothetical protein	NA	NA	NA	NA
WP_001222133.1\|621679_622396_+	hypothetical protein	NA	NA	NA	NA
WP_001045420.1\|622564_623353_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_001018677.1\|623605_623980_-	transcriptional regulator	NA	NA	NA	NA
WP_000169042.1\|626051_626276_-	DUF2922 domain-containing protein	NA	NA	NA	NA
WP_000036088.1\|626292_626496_-	DUF1659 domain-containing protein	NA	NA	NA	NA
WP_001044915.1\|626654_627215_+\|integrase	tyrosine-type recombinase/integrase	A0A141E172	Streptococcus_phage	5.7e-19	35.1
WP_020977037.1\|627233_629636_+	Na+/H+ antiporter Mnh2 subunit A	NA	NA	NA	NA
WP_000661906.1\|629622_630048_+	Na+/H+ antiporter Mnh2 subunit B	NA	NA	NA	NA
WP_001048985.1\|630044_630389_+	Na+/H+ antiporter Mnh2 subunit C	NA	NA	NA	NA
WP_000950548.1\|630378_631875_+	Na+/H+ antiporter Mnh2 subunit D	NA	NA	NA	NA
WP_001071971.1\|631875_632358_+	Na+/H+ antiporter Mnh2 subunit E	NA	NA	NA	NA
WP_000616642.1\|632354_632657_+	Na+/H+ antiporter Mnh2 subunit F	NA	NA	NA	NA
WP_000406615.1\|632631_633069_+	Na+/H+ antiporter Mnh2 subunit G	NA	NA	NA	NA
WP_000402172.1\|633408_635451_+	sodium:proton antiporter	NA	NA	NA	NA
634832:634847	attR	NA	NA	NA	NA
WP_000737654.1\|636410_637340_-	metal ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000889250.1\|637336_638173_-	metal ABC transporter permease	NA	NA	NA	NA
WP_000894464.1\|638166_638910_-	metal ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	1.2e-11	29.7
WP_000954654.1\|639031_639676_+	metal-dependent transcriptional regulator	NA	NA	NA	NA
WP_020977038.1\|639755_640508_-	M50 family metallopeptidase	NA	NA	NA	NA
WP_000215385.1\|640743_641508_+	WecB/TagA/CpsF family glycosyltransferase	NA	NA	NA	NA
WP_001103232.1\|641568_642363_-	teichoic acids export ABC transporter ATP-binding subunit TagH	NA	NA	NA	NA
WP_001273058.1\|642709_643522_+	teichoic acids export ABC transporter permease subunit TagG	NA	NA	NA	NA
WP_001101590.1\|643620_644724_+	CDP-glycerol glycerophosphotransferase family protein	NA	NA	NA	NA
WP_020977039.1\|644720_645782_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_000832260.1\|645844_646243_+	glycerol-3-phosphate cytidylyltransferase	A0A222YWT0	Streptomyces_phage	3.2e-16	39.9
WP_020977040.1\|646359_647655_-	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	2.0e-14	26.9
WP_000817960.1\|648075_649803_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	9.7e-110	43.3
WP_000479279.1\|650165_651395_+	nucleoside permease	NA	NA	NA	NA
WP_000114226.1\|651729_652134_+	HK97 gp10 family phage protein	G4KNQ5	Staphylococcus_phage	4.3e-69	100.0
WP_000565498.1\|652130_652538_+	hypothetical protein	G4KNQ6	Staphylococcus_phage	7.1e-72	100.0
WP_000268740.1\|652538_653183_+\|tail	phage tail protein	G4KNQ7	Staphylococcus_phage	6.5e-120	100.0
WP_072472712.1\|653224_653449_+	Ig-like domain-containing protein	A0A075LYE8	Staphylococcus_phage	8.8e-32	98.6
WP_001096355.1\|653498_653849_+	hypothetical protein	G4KNQ8	Staphylococcus_phage	7.8e-59	100.0
WP_020977042.1\|654094_658639_+\|tail	phage tail tape measure protein	A0A075M036	Staphylococcus_phage	0.0e+00	98.8
WP_020977044.1\|660135_663921_+	bacteriophage minor structural protein	C8CH32	Staphylococcus_phage	0.0e+00	99.4
WP_001153681.1\|663910_664063_+	hypothetical protein	D2JLG0	Staphylococcus_phage	5.2e-20	100.0
WP_001040261.1\|664109_664397_+	hypothetical protein	D2JLG1	Staphylococcus_phage	1.3e-43	100.0
WP_000539688.1\|664454_664751_+	DUF2951 domain-containing protein	D2JLG2	Staphylococcus_phage	2.9e-46	100.0
WP_011447039.1\|664900_665077_+\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	2.2e-22	98.3
WP_001791821.1\|665129_665237_-	hypothetical protein	NA	NA	NA	NA
WP_000611512.1\|665288_665543_+\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_000861038.1\|665554_666310_+	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
WP_000920037.1\|666500_666992_+	staphylokinase	A0A1W6JQ12	Staphylococcus_phage	3.6e-86	100.0
WP_000702263.1\|669206_669557_+	complement inhibitor SCIN-A	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
WP_020977045.1\|669838_671485_+\|transposase	IS1182 family transposase	A0A146ICT8	Staphylococcus_phage	1.9e-293	100.0
WP_001791826.1\|671532_671793_-	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_042908639.1\|672103_672283_-	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	3.5e-23	96.6
WP_001788321.1\|672710_672803_+	hypothetical protein	NA	NA	NA	NA
WP_001044662.1\|672980_673814_+	YitT family protein	NA	NA	NA	NA
WP_001080809.1\|674094_674892_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-18	30.7

DBSCAN-SWA_2

732003 : 739823

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244415.1\|732003_733059_-	two-component system sensor histidine kinase SaeS	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|733058_733745_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037807.1\|733719_734193_-	DoxX family protein	NA	NA	NA	NA
WP_001093553.1\|734534_734975_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637683.1\|735254_735839_-	hypothetical protein	NA	NA	NA	NA
WP_001062976.1\|735937_736651_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941336.1\|736654_737074_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_020977067.1\|737075_737744_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604519.1\|738094_738688_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	5.8e-38	42.9
WP_020977068.1\|738671_739823_+	aminodeoxychorismate synthase component I	S4VNU7	Pandoravirus	2.4e-24	36.5

DBSCAN-SWA_3

754295 : 768242

uncultured_Caudovirales_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000429011.1\|754295_755213_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	6.2e-07	22.0
WP_031760357.1\|755305_755407_+	hypothetical protein	NA	NA	NA	NA
WP_020977045.1\|755711_757358_+\|transposase	IS1182 family transposase	A0A146ICT8	Staphylococcus_phage	1.9e-293	100.0
WP_000193751.1\|757399_758905_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930014.1\|759245_759746_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.9e-52	71.5
WP_001068497.1\|759765_760632_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|761432_761831_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855505.1\|761793_763899_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|764016_764988_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000499195.1\|765375_765531_+	hypothetical protein	NA	NA	NA	NA
WP_000876318.1\|765569_766541_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.3e-139	78.9
WP_001245575.1\|766527_767484_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000616870.1\|767480_768242_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	5.0e-18	31.6

DBSCAN-SWA_4

940513 : 987529

Lactococcus_phage(33.33%)

tRNA,transposase,protease,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000093393.1\|940513_940999_+\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	4.9e-19	35.4
WP_001180264.1\|941634_942516_+	ABC transporter permease	NA	NA	NA	NA
WP_000448931.1\|942557_943547_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_000258003.1\|943841_944237_+	transcriptional regulator Spx	NA	NA	NA	NA
WP_001217728.1\|944607_945327_+	adaptor protein MecA	NA	NA	NA	NA
WP_020977132.1\|945447_946434_+	hypothetical protein	NA	NA	NA	NA
WP_020977133.1\|946481_948290_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	5.5e-47	24.5
WP_000093393.1\|948884_949370_+\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	4.9e-19	35.4
WP_000896697.1\|949492_950299_-\|protease	protease adaptor protein YjbH	NA	NA	NA	NA
WP_000214067.1\|950321_950687_-	truncated hemoglobin	NA	NA	NA	NA
WP_000224622.1\|950790_951384_-	CYTH domain-containing protein	NA	NA	NA	NA
WP_020977134.1\|951569_951917_+	hypothetical protein	NA	NA	NA	NA
WP_001077683.1\|951933_952569_+	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_001270834.1\|952585_953395_+	NAD kinase	NA	NA	NA	NA
WP_020977135.1\|953391_954246_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_000062404.1\|954266_955652_+	magnesium transporter	NA	NA	NA	NA
WP_000395153.1\|955661_957506_+	monovalent cation:proton antiporter family protein	NA	NA	NA	NA
WP_000933195.1\|957783_958554_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_000933105.1\|958750_959836_-	AI-2E family transporter	NA	NA	NA	NA
WP_000570701.1\|960177_961746_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_020977136.1\|961888_962647_+	esterase family protein	NA	NA	NA	NA
WP_020977137.1\|962812_963538_+	hypothetical protein	NA	NA	NA	NA
WP_000600387.1\|965124_965634_+	2'-5' RNA ligase family protein	NA	NA	NA	NA
WP_001154224.1\|967850_969041_-	MFS transporter	NA	NA	NA	NA
WP_000258650.1\|969018_970194_-	diglucosyl diacylglycerol synthase	NA	NA	NA	NA
WP_020977140.1\|970626_972111_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_078066272.1\|972091_972352_+	YueH family protein	NA	NA	NA	NA
WP_001049957.1\|972351_973914_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	2.2e-36	28.2
WP_000928413.1\|974215_975019_+	TerC family protein	S5MAL1	Bacillus_phage	1.6e-30	40.5
WP_020977142.1\|975237_977562_+\|protease	serine protease	W5SAB9	Pithovirus	2.1e-11	27.4
WP_000021872.1\|977578_978937_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_042908661.1\|979075_980587_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000287265.1\|981075_981645_-	competence protein ComK	NA	NA	NA	NA
WP_000876826.1\|981854_982073_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000668820.1\|982153_983140_-	lipoate--protein ligase	NA	NA	NA	NA
WP_000214898.1\|983338_983515_+	YkvS family protein	NA	NA	NA	NA
WP_001033867.1\|983529_984132_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_042908823.1\|987262_987529_+\|bacteriocin	bacteriocin transporter	NA	NA	NA	NA

DBSCAN-SWA_5

1021732 : 1030205

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000861570.1\|1021732_1022215_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	8.0e-22	44.7
WP_001010401.1\|1022201_1023326_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174047.1\|1023329_1024034_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	1.4e-46	41.2
WP_000848350.1\|1024033_1024297_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666799.1\|1024298_1024970_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032747.1\|1024962_1027152_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.8e-140	39.7
WP_000483727.1\|1027130_1028615_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.6e-44	31.5
WP_000030812.1\|1028607_1029636_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.3e-61	41.4
WP_020977150.1\|1029638_1030205_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.0e-28	40.1

DBSCAN-SWA_6

1539755 : 1548067

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1539755_1540541_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924214.1\|1540666_1541557_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_001062177.1\|1541566_1542913_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	2.4e-55	34.0
WP_020977299.1\|1543026_1544127_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	1.6e-09	30.6
WP_020977300.1\|1544129_1544807_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283055.1\|1544937_1546044_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217250.1\|1546267_1548067_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.5e-54	36.0

DBSCAN-SWA_7

1617373 : 1626416

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364543.1\|1617373_1617892_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	2.1e-28	45.8
WP_020977314.1\|1617913_1620187_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	2.8e-64	29.5
WP_000749796.1\|1620389_1622669_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1622943_1623204_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1623222_1624362_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_020977315.1\|1624384_1625410_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005767.1\|1625411_1626416_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_8

1757357 : 1820323

Staphylococcus_phage(91.3%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020977346.1\|1757357_1763915_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	5.0e-300	93.2
WP_000836465.1\|1764240_1764552_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	1.6e-52	100.0
WP_020977347.1\|1764573_1766991_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.3
WP_001025061.1\|1767279_1768461_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
WP_000526539.1\|1768570_1769524_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
WP_020977348.1\|1769520_1770084_+	class I SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	2.4e-102	98.9
WP_020977349.1\|1770203_1770605_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266096.1\|1771177_1772005_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_078062663.1\|1772007_1772127_-	hypothetical protein	NA	NA	NA	NA
WP_020977350.1\|1772238_1773240_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	3.4e-184	99.4
WP_001008551.1\|1773361_1773826_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
WP_020977351.1\|1773838_1775020_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	5.6e-226	99.5
WP_000493886.1\|1775030_1775663_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	6.4e-112	99.0
WP_000077341.1\|1775669_1776713_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	9.1e-196	98.8
WP_020977352.1\|1777193_1778696_-	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	1.1e-29	98.6
WP_000221187.1\|1779217_1779532_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	3.7e-52	96.2
WP_020977353.1\|1779531_1780824_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	1.3e-223	97.7
WP_000163240.1\|1780841_1781237_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	2.4e-72	99.2
WP_001032836.1\|1781696_1782551_-	N-acetylglucosaminidase	Q4ZCC7	Staphylococcus_virus	4.9e-38	38.1
WP_000384171.1\|1782826_1783051_-	hypothetical protein	NA	NA	NA	NA
WP_000671047.1\|1783249_1783720_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	4.4e-81	97.4
WP_001153738.1\|1783832_1784276_+	competence protein ComK	NA	NA	NA	NA
WP_020977354.1\|1784262_1784706_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	3.5e-56	97.3
WP_020977355.1\|1785003_1785639_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_000492902.1\|1785805_1786426_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001096494.1\|1786894_1787608_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091445.1\|1787866_1788169_+	hypothetical protein	NA	NA	NA	NA
WP_001200550.1\|1788424_1788790_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.2e-59	98.3
WP_020977356.1\|1788786_1789140_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	7.7e-22	96.6
WP_020977357.1\|1789389_1790223_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.1e-156	98.9
WP_000366163.1\|1790434_1791343_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.4e-138	100.0
WP_000933822.1\|1791467_1792661_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000109912.1\|1793031_1794624_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.8
WP_078064595.1\|1794917_1795664_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	2.1e-141	98.4
WP_000672013.1\|1795668_1796142_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	7.2e-84	98.7
WP_000718107.1\|1796207_1796465_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_020977358.1\|1796461_1797463_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	4.5e-184	96.7
WP_020977359.1\|1797467_1798946_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	5.8e-281	96.5
WP_078066316.1\|1799104_1799560_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	2.6e-78	97.3
WP_020977361.1\|1799860_1800511_+	excalibur calcium-binding domain-containing protein	A0A2H4PQM8	Staphylococcus_phage	2.8e-30	61.1
WP_020977362.1\|1800591_1801587_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	2.0e-67	93.1
WP_000669045.1\|1801662_1802289_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	8.1e-83	85.6
WP_000627534.1\|1802329_1802671_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	2.8e-53	93.8
WP_000414218.1\|1802771_1803344_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	2.7e-24	93.1
WP_000809860.1\|1803673_1803859_-	hypothetical protein	NA	NA	NA	NA
WP_000375478.1\|1803860_1804037_-	hypothetical protein	NA	NA	NA	NA
WP_000251969.1\|1804743_1804980_-\|transposase	IS3 family transposase	A0A0C5AJ30	Paenibacillus_phage	1.0e-17	64.1
WP_001801861.1\|1805124_1805220_+	type I toxin-antitoxin system Fst family toxin PepA1	NA	NA	NA	NA
WP_000728661.1\|1806160_1806604_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000731420.1\|1806603_1807047_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000747798.1\|1807046_1807490_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_020977363.1\|1808019_1810440_+	polysaccharide lyase 8 family protein	NA	NA	NA	NA
WP_001044453.1\|1810499_1811354_-	M23 family metallopeptidase	E5G070	Clostridium_phage	2.2e-06	39.7
WP_000072571.1\|1811606_1812827_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	3.3e-48	36.2
WP_020977364.1\|1812819_1814376_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	1.5e-287	99.2
WP_020977365.1\|1814739_1815459_-\|protease	serine protease	A0A2H4PQP1	Staphylococcus_phage	9.9e-125	94.6
WP_020977366.1\|1815633_1816350_-\|protease	serine protease	A0A2H4PQN5	Staphylococcus_phage	3.8e-84	63.0
WP_042908835.1\|1816472_1817192_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	1.6e-122	93.3
WP_020977368.1\|1817249_1817972_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	2.1e-127	96.7
WP_020977369.1\|1818096_1818804_-\|protease	serine protease SplA	A0A2H4PQN3	Staphylococcus_phage	1.1e-125	96.6
WP_020977370.1\|1819759_1820323_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	9.6e-51	61.9

DBSCAN-SWA_9

1913833 : 1991131

Staphylococcus_phage(62.86%)

coat,protease,integrase,terminase,tRNA,transposase

attL 1974395:1974414|attR 1989153:1989172

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000170162.1\|1913833_1914136_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_020977399.1\|1914500_1916039_+	sodium/proline symporter PutP	NA	NA	NA	NA
WP_020977400.1\|1916127_1917327_-	CamS family sex pheromone protein	NA	NA	NA	NA
WP_020977401.1\|1917339_1919343_-	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	1.2e-114	36.2
WP_000992919.1\|1919346_1921539_-	DNA helicase PcrA	A7KV33	Bacillus_phage	1.0e-135	42.2
WP_000272064.1\|1921535_1922228_-	heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
WP_001165363.1\|1922399_1922702_-	hypothetical protein	NA	NA	NA	NA
WP_000572876.1\|1922810_1924106_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.6e-16	32.9
WP_020977402.1\|1924965_1926132_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434533.1\|1926162_1926489_+	staphostatin A	NA	NA	NA	NA
WP_000669861.1\|1926778_1926952_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011542.1\|1926932_1927535_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040873.1\|1927806_1928628_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	1.8e-69	52.7
WP_020977403.1\|1928620_1930090_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	5.9e-108	44.9
WP_020977404.1\|1930273_1931350_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_020977405.1\|1931369_1932164_+	prephenate dehydratase	NA	NA	NA	NA
WP_042908733.1\|1932235_1932343_+	hypothetical protein	NA	NA	NA	NA
WP_000323161.1\|1932353_1933916_-	SLC13 family permease	NA	NA	NA	NA
WP_020977406.1\|1934120_1935218_-	hypothetical protein	U5PWM6	Bacillus_phage	1.5e-47	34.6
WP_000149686.1\|1935589_1936150_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140868.1\|1936202_1937132_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001790680.1\|1937324_1937498_-	hypothetical protein	NA	NA	NA	NA
WP_001021226.1\|1937549_1938929_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_020977407.1\|1939048_1940077_-	lactonase family protein	NA	NA	NA	NA
WP_020977408.1\|1940536_1940917_-	penicillinase repressor BlaI	NA	NA	NA	NA
WP_020977409.1\|1940906_1942664_-	beta-lactam sensor/signal transducer BlaR1	NA	NA	NA	NA
WP_020977410.1\|1942770_1943616_+	penicillin-hydrolyzing class A beta-lactamase BlaZ	A0A1B0VBP7	Salmonella_phage	1.3e-30	33.9
WP_020977411.1\|1943924_1944386_+	YolD-like family protein	U3PG23	Staphylococcus_phage	1.2e-27	50.4
WP_020977045.1\|1944354_1946001_-\|transposase	IS1182 family transposase	A0A146ICT8	Staphylococcus_phage	1.9e-293	100.0
WP_020977412.1\|1946287_1947658_-	hypothetical protein	NA	NA	NA	NA
WP_020977413.1\|1948034_1950098_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_020977414.1\|1950100_1951213_-\|integrase	tyrosine-type recombinase/integrase	P97010	Streptococcus_pyogenes_phage	7.8e-12	32.2
WP_000267033.1\|1952272_1952446_-	hypothetical protein	NA	NA	NA	NA
WP_020977415.1\|1952896_1953937_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_020977416.1\|1953993_1954836_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001033968.1\|1954832_1955390_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966288.1\|1955449_1955974_-	membrane protein	NA	NA	NA	NA
WP_000182842.1\|1956094_1956658_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221650.1\|1956723_1957464_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_020977417.1\|1957463_1958336_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_000645729.1\|1958332_1959013_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991298.1\|1959013_1959910_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	1.1e-16	30.2
WP_000691584.1\|1959906_1960287_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681969.1\|1960827_1961004_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|1961245_1961344_-	hypothetical protein	NA	NA	NA	NA
WP_001068527.1\|1961543_1962830_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_020977418.1\|1963395_1965162_-	extracellular adherence protein Eap/Map	NA	NA	NA	NA
WP_000953545.1\|1965704_1966544_+	sphingomyelin phosphodiesterase	A0A1P8L6H7	Staphylococcus_phage	1.5e-161	99.6
WP_000595398.1\|1967036_1968053_-	bi-component leukocidin LukGH subunit G	A0A2I6PER8	Staphylococcus_phage	6.7e-26	28.4
WP_000791403.1\|1968074_1969130_-	bi-component leukocidin LukGH subunit H	A0A1X9IGW5	Staphylococcus_phage	2.1e-35	34.3
WP_020977419.1\|1969565_1970789_+	ArgE/DapE family deacylase	NA	NA	NA	NA
WP_020977420.1\|1971172_1972480_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_025174465.1\|1973050_1973392_-	hypothetical protein	C8CH40	Staphylococcus_phage	3.3e-22	47.8
WP_000201397.1\|1973673_1973853_-	hypothetical protein	NA	NA	NA	NA
1974395:1974414	attL	NA	NA	NA	NA
WP_000767003.1\|1974871_1975564_-	S8 family serine peptidase	NA	NA	NA	NA
WP_000368755.1\|1975550_1976156_-	DUF3885 domain-containing protein	NA	NA	NA	NA
WP_000708297.1\|1976169_1976919_-	hypothetical protein	NA	NA	NA	NA
WP_020977422.1\|1978512_1979082_-\|terminase	terminase small subunit	Q4ZE85	Staphylococcus_phage	6.6e-100	96.8
WP_020977423.1\|1979078_1979420_-	hypothetical protein	A0A1W6JQM3	Staphylococcus_phage	4.9e-58	99.1
WP_020977424.1\|1979422_1979950_-\|coat	spore coat protein	A0A1W6JQH7	Staphylococcus_phage	4.9e-89	98.9
WP_001160678.1\|1980002_1980179_-	hypothetical protein	A0A1W6JQJ5	Staphylococcus_phage	7.7e-23	100.0
WP_000856046.1\|1980178_1980757_-	hypothetical protein	A0A1W6JQG0	Staphylococcus_phage	7.8e-80	95.8
WP_001288441.1\|1980791_1981136_-	hypothetical protein	A0A1W6JQF3	Staphylococcus_phage	1.4e-57	100.0
WP_020977425.1\|1981846_1982488_-	mobile element-associated protein	Q4ZE67	Staphylococcus_phage	3.6e-110	92.0
WP_020977426.1\|1982484_1982865_-	hypothetical protein	Q4ZE71	Staphylococcus_phage	3.2e-66	96.0
WP_000447470.1\|1983194_1984895_-	DUF927 domain-containing protein	Q4ZE73	Staphylococcus_phage	1.3e-308	95.2
WP_001002689.1\|1984908_1985778_-	primase C-terminal domain-containing protein	Q4ZE74	Staphylococcus_phage	1.5e-164	96.2
WP_001103944.1\|1985844_1986165_-	DUF1474 family protein	A0A1W6JQH0	Staphylococcus_phage	6.5e-20	58.2
WP_001058486.1\|1986167_1986377_-	hypothetical protein	Q4ZE76	Staphylococcus_phage	1.7e-29	94.2
WP_000708434.1\|1986369_1986516_-	hypothetical protein	NA	NA	NA	NA
WP_020977427.1\|1986512_1986830_-	helix-turn-helix domain-containing protein	A0A1W6JQE0	Staphylococcus_phage	7.8e-50	96.2
WP_000153640.1\|1986834_1987053_-	helix-turn-helix transcriptional regulator	A0A2H4JB11	uncultured_Caudovirales_phage	1.3e-19	66.7
WP_000620857.1\|1987225_1987900_+	helix-turn-helix transcriptional regulator	A0A2H4JGT9	uncultured_Caudovirales_phage	1.6e-39	45.8
WP_000179346.1\|1987913_1989086_+\|integrase	tyrosine-type recombinase/integrase	A0A1W6JQD3	Staphylococcus_phage	1.3e-219	97.9
WP_020977428.1\|1989154_1990771_-	chaperonin GroEL	A0A240F779	uncultured_virus	4.4e-157	54.7
1989153:1989172	attR	NA	NA	NA	NA
WP_000917289.1\|1990846_1991131_-	co-chaperone GroES	A0A221S386	uncultured_virus	4.7e-14	46.2

Anti-CRISPR protein detection

Acr_ID: NC_022222.1|WP_000681969.1|1960827_1961004_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NC_022222.1|WP_000990056.1|1961245_1961344_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NC_022222.1|WP_000681969.1|1960827_1961004_-|hypothetical-protein

1960827_1961004_-

58 aa aa

1913833-1991131

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_022222_10	Orphan	10.1\|2729896\|26\|NC_022222\|CRISPRCasFinder	2729896-2729921	26	1960641-1960666	1

1. spacer 10.1|2729896|26|NC_022222|CRISPRCasFinder matches to NC_022222 position: 1960641-1960666, mismatch: 1

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgacagcttctatgttggggccccg	Protospacer
*** **********************

NC_022222.1|WP_000990056.1|1961245_1961344_-|hypothetical-protein

1961245_1961344_-

32 aa aa

1913833-1991131

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NC_022222_10	Orphan	10.1\|2729896\|26\|NC_022222\|CRISPRCasFinder	2729896-2729921	26	1960641-1960666	1

1. spacer 10.1|2729896|26|NC_022222|CRISPRCasFinder matches to NC_022222 position: 1960641-1960666, mismatch: 1

ccgccagcttctatgttggggccccg	CRISPR spacer
ccgacagcttctatgttggggccccg	Protospacer
*** **********************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022222

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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