CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NC_022227	Staphylococcus aureus subsp. aureus CN1 plasmid unnamed, complete sequence	0 crisprs	csa3	0	0	0
NC_022226	Staphylococcus aureus subsp. aureus CN1, complete sequence	8 crisprs	cas3,DEDDh,DinG,csa3,WYL	3	3	7
NC_022228	Staphylococcus aureus subsp. aureus CN1 plasmid unnamed, complete sequence	0 crisprs	NA	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022226_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022226_1

260108-260198

Orphan

Consensus_repeat	Method
GGGCCCACACCCCAACTTGCATTGCCTGTAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022226_1

>merge|NC_022226|1|260108-260198|CRISPRCasFinder
GGGCCCACACCCCAACTTGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTTTGTTGGGGCCCACACCCCAACTTGCATTGTCTGTAGAA

>NC_022226|1|1|260108-260198|CRISPRCasFinder
GGGCCCACACCCCAACTTGCATTGCCTGTAGAA	TTTCTTTTCGAAATTCTCTTTGTTG
GGGCCCACACCCCAACTTGCATTGTCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022226.1\|WP_000646203.1\|253320_254376_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176219
NC_022226.1\|WP_001792906.1\|270934_271378_+\|antiholin-like-murein-hydrolase-modulator-LrgA	unknown	unknown	gnl\|CDD\|235222
NC_022226.1\|WP_000610207.1\|262773_263799_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176199
NC_022226.1\|WP_000610188.1\|256827_257853_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176199
NC_022226.1\|WP_000598262.1\|260619_261789_+\|CDP-glycerol-glycerophosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|367953
NC_022226.1\|WP_000975365.1\|265541_267263_+\|poly(ribitol-phosphate)-beta-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|376098
NC_022226.1\|WP_000240920.1\|263820_265509_+\|CDP-glycerol-glycerophosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|367953
NC_022226.1\|WP_000531476.1\|251048_251516_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129
NC_022226.1\|WP_000645456.1\|270081_270822_+\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|184495
NC_022226.1\|WP_000607067.1\|271370_272072_+\|antiholin-like-protein-LrgB	unknown	unknown	gnl\|CDD\|179810
NC_022226.1\|WP_000815795.1\|251538_251817_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NC_022226.1\|WP_000872486.1\|262064_262781_+\|D-ribitol-5-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|184017
NC_022226.1\|WP_001012739.1\|248967_251064_+\|transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_022226.1\|WP_000608831.1\|267406_268081_+\|iron-sulfur-cluster-repair-di-iron-protein-ScdA	unknown	unknown	gnl\|CDD\|183940
NC_022226.1\|WP_020977989.1\|252043_253303_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NC_022226.1\|WP_000950281.1\|268324_270079_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225814
NC_022226.1\|WP_000167984.1\|257874_259569_+\|CDP-glycerol-glycerophosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|367953
NC_022226.1\|WP_000638475.1\|256118_256835_+\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|184017
NC_022226.1\|WP_000645601.1\|254547_255591_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NC_022226.1\|WP_000230358.1\|254377_254524_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022226.1\|WP_000646203.1\|253320_254376_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176219	cd08258, Zn_ADH4, Alcohol dehydrogenases of the MDR family. This group shares the zinc coordination sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of an beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.06411e-146
NC_022226.1\|WP_000610207.1\|262773_263799_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176199	cd08237, ribitol-5-phosphate_DH, ribitol-5-phosphate dehydrogenase. NAD-linked ribitol-5-phosphate dehydrogenase, a member of the MDR/zinc-dependent alcohol dehydrogenase-like family, oxidizes the phosphate ester of ribitol-5-phosphate to xylulose-5-phosphate of the pentose phosphate pathway. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.	0
NC_022226.1\|WP_000610188.1\|256827_257853_+\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176199	cd08237, ribitol-5-phosphate_DH, ribitol-5-phosphate dehydrogenase. NAD-linked ribitol-5-phosphate dehydrogenase, a member of the MDR/zinc-dependent alcohol dehydrogenase-like family, oxidizes the phosphate ester of ribitol-5-phosphate to xylulose-5-phosphate of the pentose phosphate pathway. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.	8.17637e-179
NC_022226.1\|WP_000598262.1\|260619_261789_+\|CDP-glycerol-glycerophosphotransferase-family-protein	gnl\|CDD\|367953	pfam04464, Glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase. Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerization of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate units from CDP-glycerol to the linkage unit lipid.	1.25735e-161
NC_022226.1\|WP_000975365.1\|265541_267263_+\|poly(ribitol-phosphate)-beta-N-acetylglucosaminyltransferase	gnl\|CDD\|376098	pfam18674, TarS_C1, TarS beta-glycosyltransferase C-terminal domain 1. Beta-glycosyltransferase TarS is an enzyme responsible for the glycosylation of wall teichoic acid polymers of the S. aureus cell wall, a process that has been shown to be specifically responsible for methicillin resistance in MRSA. It contains a trimerization domain composed of tandem carbohydrate binding motifs.The two C-terminally localized regions composed of a series of beta-sheets participate in an extensive trimerization interface and they assume an immunoglobulin-like fold. It is suggested that both carbohydrate binding domains may be involved in polyRboP binding, however unlike pullulanase, the CBMs of TarS are involved in the formation of an extensive trimerization interface.	6.64158e-35
NC_022226.1\|WP_000240920.1\|263820_265509_+\|CDP-glycerol-glycerophosphotransferase-family-protein	gnl\|CDD\|367953	pfam04464, Glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase. Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerization of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate units from CDP-glycerol to the linkage unit lipid.	4.42901e-119
NC_022226.1\|WP_000531476.1\|251048_251516_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	1.27465e-37
NC_022226.1\|WP_001792906.1\|270934_271378_+\|antiholin-like-murein-hydrolase-modulator-LrgA	gnl\|CDD\|235222	PRK04125, PRK04125, antiholin-like protein LrgA.	8.44339e-64
NC_022226.1\|WP_000607067.1\|271370_272072_+\|antiholin-like-protein-LrgB	gnl\|CDD\|179810	PRK04288, PRK04288, antiholin-like protein LrgB; Provisional.	5.86643e-124
NC_022226.1\|WP_000815795.1\|251538_251817_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	3.43648e-34
NC_022226.1\|WP_000638475.1\|256118_256835_+\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|184017	PRK13385, PRK13385, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Provisional.	3.70751e-127
NC_022226.1\|WP_001012739.1\|248967_251064_+\|transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	9.95484e-84
NC_022226.1\|WP_000608831.1\|267406_268081_+\|iron-sulfur-cluster-repair-di-iron-protein-ScdA	gnl\|CDD\|183940	PRK13276, PRK13276, iron-sulfur cluster repair di-iron protein ScdA.	7.18502e-154
NC_022226.1\|WP_020977989.1\|252043_253303_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	0
NC_022226.1\|WP_000950281.1\|268324_270079_+\|sensor-histidine-kinase	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	0
NC_022226.1\|WP_000167984.1\|257874_259569_+\|CDP-glycerol-glycerophosphotransferase-family-protein	gnl\|CDD\|367953	pfam04464, Glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase. Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerization of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate units from CDP-glycerol to the linkage unit lipid.	1.00668e-114
NC_022226.1\|WP_000872486.1\|262064_262781_+\|D-ribitol-5-phosphate-cytidylyltransferase	gnl\|CDD\|184017	PRK13385, PRK13385, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Provisional.	2.28851e-105
NC_022226.1\|WP_000645601.1\|254547_255591_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	9.45294e-176
NC_022226.1\|WP_000645456.1\|270081_270822_+\|DNA-binding-response-regulator	gnl\|CDD\|184495	PRK14084, PRK14084, DNA-binding response regulator.	4.37999e-152

>NC_022226.1|WP_000167984.1|257874_259569_+|CDP-glycerol-glycerophosphotransferase-family-protein
MTKTKQAIHIDNIYWERVQLYIEGHSEGVDLTSGQFVLRNLTETKTLEANEMKIDGNTFICRFNVAILDDGYYLPMDKYLFVYHDQLEYIGQLNPNIIDQAYAALNEEQIEEYNELTTQNGKVNYLLAYDAKVFRKGGVSQHTVYTITPEIASDVNEFVFDIEITLPQEKSGVIATSAHWLHKQGHKASFESRSFLFKAIFNITKLLHIKRSKTILFTSDSRPNLSGNFKYVYDELLRQKVDFDYDIKTVFKANITDRRKWRDKFRLPYLLGKADYIFVDDFHPLIYTVRFRPSQEIIQVWHAVGAFKTVGFSRTGKKGGPFIDSLNHRSYTKAYVSSETDIPFYAEAFGIREENVVPTGVPRTDVLFDETYATQIKQEMEDELPIIKGKKVILFAPTFRGNGHGTAHYPFFKIDFERLARYCEKNNAVVLFKMHPFVKNRLNISREHRQYFIDVSDYREVNDILFVTDLLISDYSSLIYEYAVFKKPMIFYAFDLEDYITTRDFYEPYESFVPGKIVQSFDALMDALDNEDYEVEKVVPFLDKHFKYQDGRSSERLVKDLFRR
>NC_022226.1|WP_000610188.1|256827_257853_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MINQVYQLVAPRQFDVTYNNVDIYGNHVIVRPLYLSICAADQRYYTGRRDENVLRKKLPMSLVHEAVGEVVFDSKGVFEKGTKVVMVPNTPTEQHHIIAENYLASSYFRSSGYDGFMQDYVVMAHDRIVPLPNDIDLSTISYTELVSVSYHAIQRFERKSIPLKTSFGIWGDGNLGYITAILLRKLYPEAKTYVFGKTDYKLSHFSFVDDIFTVNQIPDDLKIDHAFECVGGKGSQVALQQIVEHISPEGSIALLGVSELPVEVNTRLVLEKGLTLIGSSRSGSKDFEQVVDLYRKYPDIVEKLALLKGHEINVCTMQDIVQAFEKDLSTSWGKTVLKWTI
>NC_022226.1|WP_000638475.1|256118_256835_+|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MIYAGILAGGIGSRMGNVPLPKQFLDIDNKPILIHTIEKFILVSEFNEIIIATPAQWISHTQDILKKYNITDQRVKVVAGGTDRNETIMNIIDHIRNVNGINNDDVIVTHDAVRPFLTQRIIKENIEVAAKYGAVDTVIEAIDTIVMSKDKQNIHSIPVRNEMYQGQTPQSFNIKLLQDSYRALSSEQKEILSDACKIIVESGHAVKLVRGELYNIKVTTPYDLKVANAIIQGDIADD
>NC_022226.1|WP_000645601.1|254547_255591_+|galactitol-1-phosphate-5-dehydrogenase
MKALKLYGVEDLRYEDNEKPVIESANDVIIKVRATGICGSDTSRYKKMGPYIKGMPFGHEFSGVVDAIGSDVTHVNVGDKVTGCPAIACYQCGYCLKGEYARCEKLFVIGSYEPGSFAEYVKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQPGMTVAVMGCGSIGLLAIQWARIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKVTIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTATLHYMKTKDINVKPIISHFLPLEKGPETFDKLVNKKERFDKVMFTIY
>NC_022226.1|WP_000230358.1|254377_254524_+|hypothetical-protein
MVESMLTFMLGPLRQITDFYMEHLLVSNSIVIAGYFATGIFKKKKVVN
>NC_022226.1|WP_000646203.1|253320_254376_+|zinc-binding-dehydrogenase
MKALVKTREGHGNLELLDKEVATPLDDKVKIKVHYAGICGTDIHTYEGHYKVNFPVTLGHEFSGEIVEVGADVKDFKVGDRVTSETTFYVCNECEYCKSKDYNLCNHRKGIGTQVDGAFTNYVIAREESLHHIPDEVSYQSAAMTEPLACAHHGVSKIQVNSGDVAVVMGPGPIGLLVAQVLKSKGATVVVTGLDNDKVRLDKAEALHMDYVVNLQQTDLKTYINGITDGYGADVVVECSGAVPAARQGLDILRKKGFYSQIGIFKDAEIPFDMEKVIQKEITVVGSRSQKPADWEPSLQLMADGLVNAEALVTKIYDISKWDEAYQHLKSGEGIKALLKPLDLDENEGEN
>NC_022226.1|WP_020977989.1|252043_253303_+|PTS-galactitol-transporter-subunit-IIC
MSYFTDFVRGFLDLGATVILPVVIFLLGLFFRQKIGAAFRSGLTIGVAFVGIFLVIDLLVKNLGPAAQAMVKNLGVSLNVIDVGWPATSSIAWASSVAAFIIPLGIIVNVVLLVTKVTKTMNVDIWNFWHYTFTAAMVYAVSGSIWQALLAAVIFQVICLKVADWTAPMMSEFFDLPGVSIATGSTISYAPGIYLVKLLQKVPGLNKLDADPETIQKRFGAFGESIFVGLILGLGIGVLAGYKPGDIINLGMSMAAVMVLMPRMVKILMEGLMPVSESARTWLNKRFGEREIYIGLDAAVALGHPAVISTALILVPITVLLAVILPGNQVLPFDDLATIPFVVAFIVGAARGNIIHSVIVGTIMIAISLYIATDVAPIFTDMAKGTNVQMPKGSSEISSIDQGGNIVNYLIFKLFSLFN
>NC_022226.1|WP_000815795.1|251538_251817_+|PTS-sugar-transporter-subunit-IIB
MKQVLVACGAGIATSTVVNNAIEEMAKEHNIKVDIKQIKITEVGPYEDTADLLVTTAMTKKEYKFPVINARNFLTGIGIEETKQQILTELQK
>NC_022226.1|WP_000531476.1|251048_251516_+|PTS-sugar-transporter-subunit-IIA
MGQQLVHKENIMLNLSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFATGLPTHLCSVAIPHTDVEHINHRTIGVAVLEKEVPFIEMGTLDQQTEVKIVFMLAMDKVDDQLKLLQQLMQIFQSEEKLEQILRTKDETILATLINDYLEYN
>NC_022226.1|WP_001012739.1|248967_251064_+|transcription-antiterminator
MNGDNQQILREIVLNPTIHGKELESIFGLSRRQLGYRIQKINLWLEQEGYPKLERTSQGNFIVSSEIMTLFKRDVSEQQMLNGNNVIFSIETRRYYLMLMLFSKENAMSLNHFSIDLQVSKNTVIHDINHVKEQLEDHGLSLKYSRKHGYEIVGDEFEVRRFFIKLIDQRLNHDITKSEVLKALNLTFEDIAYQKDKIKQVEQFLKSRFIDKSLSSLPYVLCVIRRRIQSGHVMNPLNINYQYLRDTKEYQATEIMTQHEPDLPEAEKLYLTLHLLSTSVQWTDLQESDSISNLTMAIAQMIHHFEQITFINIEDKEKLSQQLLLHLTPAFYRIKYNLTDRDELINPLQGNYQSLFHMVKQSCQSLTEYFGKSLPDNEIAYLTMLFGGSLRRQDENFDGKIKAIIVCTQGTSVSQMMLYELRNLFPEIIFLDAISLRTFENYTLDYDIVFSPMFVLTHKKLFITKVALSENEQRKLRKEVMKYINKESADIDKEINKLMALIERTTTVNDITELRDGLEDFIANYNSISTINGSIVTQNKTLDLADLIPARHVKRIHHVENIDEAIAKASDVLVANHFIDIKYIHEMQQVFDDSYMVIMQNIAIPHAYSEKHVHKTAMSMLILQEPIYMSDGTAIHIIVPIAAVDKVTHLRALLQLRDVAQDNDAIKRIIQSRKNSDVNEILKNYSNKEARENGWDSN
>NC_022226.1|WP_000598262.1|260619_261789_+|CDP-glycerol-glycerophosphotransferase-family-protein
MIKTTIKKLIEHSIYTTFKLLSKLPNKNLIYFESFHGKQYSDNPKALYEYLTEHSDAQLIWGVKKGYEHIFQQHNVPYVTKFSMKWFLAMPRAKAWMINTRTPDWLYKSPRTTYLQTWHGTPLKKIGLDISNVKMLGTNTQNYQDGFKKESQRWDYLVSPNPYSTSIFQHAFHVSRDKILETGYPRNDKLSHKRNDTEYINGIKTRLNIPLDKKVIMYAPTWRDDEAIREGSYQFNVNFDIEALRQALDDDYVILLRMHYLVVTRIDEHDDFVKDVSDYEDISDLYLISDALVTDYSSVMFDFGVLKRPQIFYAYDLDKYGDELRGFYMDYKKELPGPIVENQTALIDALKQIDETTNEYIEARTVFYQKFCSLEDGHASQRICQTIFK
>NC_022226.1|WP_000872486.1|262064_262781_+|D-ribitol-5-phosphate-cytidylyltransferase
MKYAGILAGGIGSRMGNVPLPKQFLDLDNKPILIHTLEKFILINDFEKIIIATPQQWMTHTKDTLRKFKISDERIEVIQGGSDRNDTIMNIVKHIESTNGINDDDVIVTHDAVRPFLTHRIIKENIQAALEYGAVDTVIDAIDTIVTSKDNQTIDAIPVRNEMYQGQTPQSFNINLLKESYAQLSDEQKSILSDACKIIVETNKPVRLVKGELYNIKVTTPYDLKVANAIIRGGIADD
>NC_022226.1|WP_000610207.1|262773_263799_+|alcohol-dehydrogenase-catalytic-domain-containing-protein
MINQVYQLVAPRQFEVTYNNVDIYSDYVIVRPLYMSICAADQRYYTGSRDENVLSQKLPMSLIHEGVGEVVFDSKGVFNKGTKVVMVPNTPTETDDVIAENYLKSSYFRSSGHDGFMQDFVLLNHDRAVPLPDDIDLSIISYTELVTVSLHAIRRFEKKSISNKNTFGIWGDGNLGYITAILLRKLYPESKIYVFGKTDYKLSHFSFVDDVFFINKIPEGLTFDHAFECVGGRGSQSAINQMIDYISPEGSIALLGVSEFPVEVNTRLVLEKGLTLIGSSRSGSKDFQDVVDLYIQYPDIVDKLALLKGQEFEIATINDLTEAFEADLSTSWGKTVLKWIM
>NC_022226.1|WP_000240920.1|263820_265509_+|CDP-glycerol-glycerophosphotransferase-family-protein
MVKSKIYIDKIYWERVQLFVEGHSENLDLEDSNFVLRNLTETRTMKANDVKIDGNQFVCRFNVAILDNGYYLPEDKYLLVNEQELDYIAQLNPDVINDAYQNLKPEQEEEYNELETQNGKINFLLQTYLKEFRKGGISKKTVYTVTPEISSDVNEFVLDVVVTTPEVKSIYIVRKYKELRKYFRKQSFNTRQFIFKAIFNTTKFFHLKKGNTVLFTSDSRPTMSGNFEYIYNEMLRQNLDKKYDIHTVFKANITDRRGIIDKFRLPYLLGKADYIFVDDFHPLIYTVRFRRSQEVIQVWHAVGAFKTVGFSRTGKKGGPFIDSLNHRSYTKAYVSSETDIPFYAEAFGIKEKNVVPTGVPRTDVLFDEAYATQIKQEMEDELPIIKGKKVILFAPTFRGSGHGTAHYPFFKIDFERLARYCEKNNAVVLFKMHPFVKNRLNIADKHKQYFVDVSDFREVNDILFITDLLISDYSSLIYEYAVFKKPMIFYAFDLEDYITTRDFYEPYESFVPGKIVQSFDALMDALDNEDYEGEKVIPFLDKHFKYQDGRSSERLVRNLFGS
>NC_022226.1|WP_000975365.1|265541_267263_+|poly(ribitol-phosphate)-beta-N-acetylglucosaminyltransferase
MMKFSVIVPTYNSEKYITELLNSLAKQDFPKTEFEVVVVDDCSTDQTLQIVEKYRNKLNLKVSQLETNSGGPGKPRNVALKQAEGEFVLFVDSDDYINKETLKDAAAFIDEHHSDVLLIKMKGVNGRGVPQSMFKETAPEVTLLNSRIIYTLSPTKIYRTTLLKDNDIYFPEELKSAEDQLFTMKAYLNANRISVLSDKAYYYATKREGEHMSSAYVSPEDFYEVMRLIAVEILNADLEEAHKDQILAEFLNRHFSFSRTNGFSLKVKLEDQPQWINALGDFIQAVPERVDALVMSKLRPLLHYARAKDIDNYRTVEESYRQGQYYRFDIVDGKLNIQFNEGEPYFEGIDIAKPKVKMTAFKFDNHKIVTELTLNEFMIGEGHYDVRLKLHSRNKKHTMYVPLSVNANKQYRFNIMLEDIKAYLPKEKIWDVFLEVQIGTEVFEVRVGNQRNKYAYTAETSALIHLNNDFYRLTPYFTKDFNNISLYFTAITLTDSISLKLKGKNKIILTGLDRGYVFEEGMASVVLKDDMIMGMLSQTSENEVEILLSKDIKKRDFKNIVKLNTAHMTYSLK
>NC_022226.1|WP_000608831.1|267406_268081_+|iron-sulfur-cluster-repair-di-iron-protein-ScdA
MINKNDIVADVVTDYPKAADIFRSVGIDFCCGGQVSIEAASLEKKNVDLNELLQRLNDVEQTNTPGSLNPKFLNVSSLIQYIQAAYHEPLREEFKNLTPYVTKLSKVHGPNHPYLVELKETYDTFKNGMLEHMQKEDDVDFPKLIKYEQGEVVDDINTVIDDLVSDHIATGQLLVKMSDLTSSYEPPIEACGTWRLVYQRLKALEVLTHEHVHLENHVLFKKVS
>NC_022226.1|WP_000950281.1|268324_270079_+|sensor-histidine-kinase
MLSLTMLLLERVGLIIILAYVLMNIPYFKNLMNRRRTWKARWQLCIIFSLFALMSNLTGIVIDHQHSLSGSVYFRLDDDVSLANTRVLTIGVAGLVGGPFVGLFVGVISGIFRVYMGGADAQVYLISSIFIGIIAGYFGLQAQRRKRYPSIAKSAMIGIVMEMIQMLSILTFSHDKAYAVDLISLIALPMIIVNSVGTAIFMSIIISTLKQEEQMKAVQTHDVLQLMNQTLPYFKEGLNRESAQQIAMIIKNLMKVSAVAITSKNEILSHVGAGSDHHIPTNEILTSLSKDVLKSGKLKEVHTKEEIGCSHPNCPLRAAIVIPLEMHGSIVGTLKMYFTNPNDLTFVERQLAEGLANIFSSQIELGEAETQSKLLKDAEIKSLQAQVSPHFFFNSINTISALVRINSEKARELLLELSYFFRANLQGSKQHTITLDKELSQVRAYLSLEQARYPGRFNININVEDKYRDVLVPPFLIQILVENAIKHAFTNRKQGNDIDVSVIKETATHVRIIVQDNGQGISKDKMHLLGETSVESESGTGSALENLNLRLKGLFGKSAALQFESTSSGTTFWCVLPYERQEEE
>NC_022226.1|WP_000645456.1|270081_270822_+|DNA-binding-response-regulator
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDENGIELGAKIQKMKEPPAIIFATAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKAKDDNSASAIANDMSANFDQSLPVEIDDKIHMLKQQNIIGIGTHNGITTIHTTNHKYETTEPLNRYEKRLNPAYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFKASIGLL
>NC_022226.1|WP_001792906.1|270934_271378_+|antiholin-like-murein-hydrolase-modulator-LrgA
MVVKQQKDASKPAHFFHQVIVIALVLFVSKIIESFMPIPMPASVIGLVLLFVLLCTGAVKLGEVEKVGTTLTNNIGLLFVPAGISVVNSLGVISQAPFLIIGLIIVSTILLLICTGYVTQIIMKVTSRSKGDKVTKKIKIEEAQAHD
>NC_022226.1|WP_000607067.1|271370_272072_+|antiholin-like-protein-LrgB
MINHLALNTPYFGILLSVIPFFLATILFEKTNRFFLFAPLFVSMVFGVAFLYLTGIPYKTYKIGGDIIYFFLEPATICFAIPLYKKREVLVKHWHRIIGGIGIGTVVALLIILTFAKLAQFANDVILSMLPQAATTAIALPVSAGIGGIKELTSLAVILNGVIIYALGNKFLKLFRITNPIARGLALGTSGHTLGVAPAKELGPVEESMASIALVLVGVVVVAVVPVFVAIFF

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Crispr_ID: NC_022226_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022226_2

400026-400127

Orphan

Consensus_repeat	Method
TTATGAATTGAGTATTAAATTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022226_2

>merge|NC_022226|2|400026-400127|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTGAAAGTAAATTACAGTTCTATAGGTTTATAAAAAATCAGTTTTTAAATCAAAGCTATATATGAATTGAGTATTAAATTTG

>NC_022226|2|2|400026-400127|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTG	AAAGTAAATTACAGTTCTATAGGTTTATAAAAAATCAGTTTTTAAATCAAAGCTAT
ATATGAATTGAGTATTAAATTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022226.1\|WP_000264071.1\|404826_406293_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NC_022226.1\|WP_000887774.1\|392608_394228_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000868264.1\|391270_391654_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000052781.1\|395881_396451_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|211789
NC_022226.1\|WP_000211678.1\|390236_390446_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000361527.1\|408370_409477_+\|Abi-family-protein	unknown	unknown	gnl\|CDD\|377910
NC_022226.1\|WP_000930514.1\|394342_395866_-\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942
NC_022226.1\|WP_020978012.1\|400143_401100_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NC_022226.1\|WP_000424963.1\|406317_407859_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NC_022226.1\|WP_000763767.1\|402022_402430_-\|general-stress-protein	unknown	unknown	gnl\|CDD\|378584
NC_022226.1\|WP_000888757.1\|410271_410664_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000394698.1\|401217_401880_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_001289311.1\|396942_397698_+\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|380322
NC_022226.1\|WP_000158377.1\|390623_391205_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NC_022226.1\|WP_000746679.1\|391909_392536_-\|NDxxF-motif-lipoprotein	unknown	unknown	gnl\|CDD\|380196
NC_022226.1\|WP_000793020.1\|403520_404789_+\|purine-permease	unknown	unknown	gnl\|CDD\|274468
NC_022226.1\|WP_001792089.1\|399250_399349_+\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000991021.1\|397777_399166_-\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
NC_022226.1\|WP_000157765.1\|410701_410917_+\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000421410.1\|402942_403521_+\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705

Protein	Function_ID	Function_description	E-value
NC_022226.1\|WP_000930514.1\|394342_395866_-\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0
NC_022226.1\|WP_000052781.1\|395881_396451_-\|peroxiredoxin	gnl\|CDD\|211789	TIGR03137, AhpC, peroxiredoxin. This peroxiredoxin (AhpC, alkylhydroperoxide reductase subunit C) is one subunit of a two-subunit complex with subunit F(TIGR03140). Usually these are found as an apparent operon. The gene has been characterized in Bacteroides fragilis, where it is important in oxidative stress defense. This gene contains two invariant cysteine residues, one near the N-terminus and one near the C-terminus, each followed immediately by a proline residue. [Cellular processes, Detoxification, Cellular processes, Adaptations to atypical conditions].	1.50623e-124
NC_022226.1\|WP_000746679.1\|391909_392536_-\|NDxxF-motif-lipoprotein	gnl\|CDD\|380196	NF033193, lipo_NDxxF, NDxxF motif lipoprotein. Members of this family are lipoproteins, about 200 amino acids long in precursor form, found in Staphylococcus aureus, Bacillus cereus, and various other Firmicutes. The protein family is named for one of its several highly conserved motifs.	1.15385e-71
NC_022226.1\|WP_020978012.1\|400143_401100_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00304381
NC_022226.1\|WP_000424963.1\|406317_407859_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NC_022226.1\|WP_000991021.1\|397777_399166_-\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
NC_022226.1\|WP_000793020.1\|403520_404789_+\|purine-permease	gnl\|CDD\|274468	TIGR03173, pbuX, xanthine permease. All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.	5.28569e-170
NC_022226.1\|WP_001289311.1\|396942_397698_+\|NADPH-dependent-oxidoreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	5.03864e-88
NC_022226.1\|WP_000158377.1\|390623_391205_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	1.30018e-49
NC_022226.1\|WP_000264071.1\|404826_406293_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NC_022226.1\|WP_000361527.1\|408370_409477_+\|Abi-family-protein	gnl\|CDD\|377910	pfam07751, Abi_2, Abi-like protein. This family, found in various bacterial species, contains sequences that are similar to the Abi group of proteins, which are involved in bacteriophage resistance mediated by abortive infection in Lactococcus species. The proteins are thought to have helix-turn-helix motifs, found in many DNA-binding proteins, allowing them to perform their function.	2.0112e-23
NC_022226.1\|WP_000763767.1\|402022_402430_-\|general-stress-protein	gnl\|CDD\|378584	pfam11181, YflT, Heat induced stress protein YflT. YflT is a heat induced protein.	2.17298e-12
NC_022226.1\|WP_000421410.1\|402942_403521_+\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	9.01486e-119

>NC_022226.1|WP_001792089.1|399250_399349_+|hypothetical-protein
MQLNVNMMKFDRWHKGICKQIVLNLVEKGEKG
>NC_022226.1|WP_000991021.1|397777_399166_-|L-cystine-transporter
MNAFLTLINIIVLVIFIVILHMMARKHISFAKRVFTALGIGIVFGVLLHLVYGTHSNVITSTSDWFNIVGQGYVALLQMIVMPLIFISIVAAFTKIQIGEKFAKIGSLIFIFLIGTVTIAAIVGVVYALVFGLDASTINLGNAEQARGSEIAKQAKDLTAHTLPQQILELLPKNPFLDFTGQRATSTIAVVIFASFIGFAYLRVARKQPDHGELLKSAIDAIYSLVMAIVTFVLRLTPYGVLAIMANTLSTSDFGAIWTLGKFLIASYAALITMYIIHLVILSLLGISPIRYVKKTLEVLIFAFTSRSSAGALPLNVQTQTRRLGVPEGIANFAATFGLSIGQNGCAGIYPAMLAIMVAPVANVEIDLQFIVTLIAVVIISSFGVAGVGGGATFASILVLSTLNLPVALAGVLISVEPLIDMGRTALNVNDSMLAGTGTAKLTKHWDKDTFESNDNAALTSH
>NC_022226.1|WP_001289311.1|396942_397698_+|NADPH-dependent-oxidoreductase
MSEHVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKENLREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAENIAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPFDHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDMLEQLQKSGLIQR
>NC_022226.1|WP_000052781.1|395881_396451_-|peroxiredoxin
MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLAQRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQPGLDLVGKI
>NC_022226.1|WP_000930514.1|394342_395866_-|alkyl-hydroperoxide-reductase-subunit-F
MLNADLKQQLKQLLELMEGNVEFVASLGSDEKSKELKELLTEISDMSPRLSLSEKSLKRTPSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKNLEGSFHFETFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNGRMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGGQVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENGAVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEAAIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYEDMSTGEEHLLNLDGIFVQIGLLPNTSWLKDAVELNERGEIVIDRNNNTNVPGIFAAGDVTDQKNKQIIISMGAGANAALNAFDYIIRN
>NC_022226.1|WP_000887774.1|392608_394228_-|hypothetical-protein
MLDVHFIYPGKLQNACEYFNLSTSKEGFEVTIHALRPENIHKIYHDMDNSEQRFIETLISKGNPVTIVNSRDVNMLKLTNHLGFVYQLNEDEFFVNNFFLRYINSEVLDNAYGEFESLDTINHMNLNEEVLRVRQHTRLNDVTLEHALLLKTNDELKTICRQYGIKGFSNKNKQNLVELIMTAFFNNNHIIEQVFSNATLFEFDILSSILESDDNYRLNNELTKFEKLQLINFDNFLTIHFYYYYDFEYDCLILPNDVRKHIENFVNQVGNGYFEKAVNQFVDEQTIENSLAEFKNALELSFMEDEVDLDMLLEDDDFEDFGTTDSLRSDAITQLISEIKKGLIDKKDILPLRIILGSVNLYGILSTNHLLYLLQRFYDATFSKEELQYSLDTLAGTELYYVEDDFVFHPVLFDVVESEASGIDISDDGYYVPASVEELIYYDRHHYLKSDQAIKEFTSYLRKQINMKNDIEKEKYVNEIIMLLRTIPTSKLIQPIMQLFIDNAILNNVQNDALLIEKATHARNHLRLWSLQGHRDIPN
>NC_022226.1|WP_000746679.1|391909_392536_-|NDxxF-motif-lipoprotein
MKKRLLLSTFLASALILTGCASDQSDNEDHHTSTGIHAPKSAKKLETKDIFNSDKKNSDISDAEMKQAIEKYLSVNSDILDNKYIMQHKLDKQIDSQTKVTEKQAETLSHLSNLAVKNDLHFKKFVTENNIPKEYKKPVELMMNYFKALNSTIANVDEDIEKLSYQPQNKINVVDVPTKYAGDVNKKQQDKIKDFLKSKGIKSDVIDK
>NC_022226.1|WP_000868264.1|391270_391654_-|hypothetical-protein
MKVRITFIILSILSTIVCLFLAAMHPTGPSTVTFEQPYLFTLNIIIMVLVALPSLVLAIYDYMSFRISSAILQFLGAISWFFLSLILSLTQFTPFTLASFITSIILFTSTIITLAIGGKSVDKNDSH
>NC_022226.1|WP_000158377.1|390623_391205_+|histidine-phosphatase-family-protein
MTIYLVRHGESKSNYDNKHFRSYFCGQLDVPLTDTGTKSADDLCDYFKEKQIKHVYVSDLLRTQQTFEHIFPYDIASTTTPLLRERSLGVFEGEYKDEISANPKYEKYFNDPNFKDFRHSFSQKAPEGESYEDVYQRVEHFMNHVVNEDTQQDDIVIVAHQVVIRCLMVYFNNVSREEAVDLKVENCKPYIIE
>NC_022226.1|WP_000211678.1|390236_390446_-|hypothetical-protein
MTTQSFIFMNIILLDGATQRHPFFICQILAFLFPTSPHVNLLLFNPILPTFLNIIIHIDHFHANKKDDN
>NC_022226.1|WP_020978012.1|400143_401100_-|hypothetical-protein
MLTKEFAQRVELSEKQVRKIVQHLEERGYQLSKTEYRGREATDFKEEDIELFKDIADKVKQTNSYDLAFDELEKEKDFLQVIVKNDDKNLPTNQNVAQLVEDLRLEIQKMREERHLFGQMMNQVHQQQQELKELQNQLTSKIDSNSESLKAIQTSQEAIQEAQASQAKVLAESTNKVEKNAVTEDKADSKDSKVAGVTTSTDAKTDTKAENAGDGTATKVDKEDQISATEAIEKASVEQSKNENAAETSNKEATVDADAQHDAEQQVAEAHAEASKQATSNDSLEAKAENDSTASQSEMSEPKPQEEKKGFFARLFNL
>NC_022226.1|WP_000394698.1|401217_401880_-|hypothetical-protein
MEFKTIQSVKDPHYNEALKLYDTKLNLSLTEDKRIIKRSLENNKTENDYVFIVGLENDVVVSLATAHYEATTNSAFLIYLFAKDLPNHDELMTQTLHQIEHELNLLSNLVHSRSINFLMMEVPKEPADLTQDNGLIIEHRRQFLYEHQFERQTEIDYIHPTNDGHTKKVDLFLKKNIKLTKDIYGTSVKSNYILKYVFANGIAREIIYALLEEMDLRKPF
>NC_022226.1|WP_000763767.1|402022_402430_-|general-stress-protein
MADITVVNDTGELYNVINQKKSEGYLESELTIISKSKLHLNDLHDSEISLISTSGTFSDRMTKLLTGEDGEHAVLSRYNLAPDELEKYKQLILDDKMLVVAVRDKSSHKEVQEHNSAYEEIDITHFAEASKGPKA
>NC_022226.1|WP_000421410.1|402942_403521_+|xanthine-phosphoribosyltransferase
MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVGEE
>NC_022226.1|WP_000793020.1|403520_404789_+|purine-permease
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILVLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIESTGVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLIICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEENVK
>NC_022226.1|WP_000264071.1|404826_406293_+|IMP-dehydrogenase
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSF
>NC_022226.1|WP_000424963.1|406317_407859_+|glutamine-hydrolyzing-GMP-synthase
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
>NC_022226.1|WP_000361527.1|408370_409477_+|Abi-family-protein
MDKSLEINLKELESIMYKEKVIDVKEYDNLKVTFETLNDAPKSEIPTPFTIEQMLYKLETKNLYFPEIKSKEKCVELLHSVGYYNLKHFMYNEFGKDEPKNFDEVYILYKFDRYLLKQLFSLVNMLETHIRNIILEVYMLEIEYNNKPSTLFYLDKDLYFEKVNDEYKYSAKKLKEFNRLQNVFWRAIEKKKSNDNVKHNIKKYNIIPAWVLFQNFSFGDLSTFYRTTLPTYRNKVSKRIENLIEKNTGISIKLPEKLLCAWLNSIRFLRNRIAHTDIIYGINFTNTCAKHHSDEEMYVNIEKYKYQQRLVTFLLAMKKIFMSMPENNIIEWNETLTKIENKCSEHNFIKLSRLGVIENNLSYFKITK
>NC_022226.1|WP_000888757.1|410271_410664_-|hypothetical-protein
MLEDNGDIRLLYQSIEELASVLGQSQFETKTVSLIFVQMDLRYSVFEKVQTDFMKYLAHKNSDEIKYIDLIKIIENALPEDKELSINVINSIIIGFANNYYPILQSLVPEIQSSYGITINKNFNIDSIDF
>NC_022226.1|WP_000157765.1|410701_410917_+|hypothetical-protein
MASLTTVEIIPASPLLRPAFIAPRLTASPTELAGTSDHFSNGFNSFTIPEYPLSKIVAAVGGGLTGGVTFC

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Crispr_ID: NC_022226_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022226_3

791979-792056

Unclear

Consensus_repeat	Method
TTCTTTATGTTGGGGCCCCGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022226_3

>merge|NC_022226|3|791979-792056|CRISPRCasFinder
TTCTTTATGTTGGGGCCCCGCCAACTTGCATTGTTTGTAGAATTTCTTTTCGAAATTCTTTATGTTGGGGCCCCGCCA

>NC_022226|3|3|791979-792056|CRISPRCasFinder
TTCTTTATGTTGGGGCCCCGCCA	ACTTGCATTGTTTGTAGAATTTCTTTTCGAAA
TTCTTTATGTTGGGGCCCCGCCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022226.1\|WP_000134961.1\|796079_797015_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NC_022226.1\|WP_000070826.1\|803969_804599_+\|DUF4887-domain-containing-protein	unknown	unknown	gnl\|CDD\|234750
NC_022226.1\|WP_000617735.1\|779334_779907_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NC_022226.1\|WP_000753321.1\|784685_785525_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NC_022226.1\|WP_001790092.1\|782893_782998_+\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000229238.1\|786850_788836_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NC_022226.1\|WP_000513313.1\|793233_794073_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NC_022226.1\|WP_072360986.1\|784430_784538_+\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_001248939.1\|798921_799917_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NC_022226.1\|WP_000057543.1\|794573_796013_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NC_022226.1\|WP_001224795.1\|794080_794566_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NC_022226.1\|WP_000369722.1\|798013_798925_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NC_022226.1\|WP_000816300.1\|802364_803267_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NC_022226.1\|WP_001049165.1\|801534_802122_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NC_022226.1\|WP_000538141.1\|785698_786349_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NC_022226.1\|WP_010956549.1\|783166_784277_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NC_022226.1\|WP_000958224.1\|792295_793228_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NC_022226.1\|WP_020978082.1\|786345_786582_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NC_022226.1\|WP_000662681.1\|788843_791690_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NC_022226.1\|WP_000506531.1\|780320_782852_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259

Protein	Function_ID	Function_description	E-value
NC_022226.1\|WP_000134961.1\|796079_797015_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	5.91243e-154
NC_022226.1\|WP_000070826.1\|803969_804599_+\|DUF4887-domain-containing-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	5.85535e-05
NC_022226.1\|WP_000617735.1\|779334_779907_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.13584e-37
NC_022226.1\|WP_000753321.1\|784685_785525_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.82721e-42
NC_022226.1\|WP_001224795.1\|794080_794566_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	5.56005e-29
NC_022226.1\|WP_000229238.1\|786850_788836_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NC_022226.1\|WP_000513313.1\|793233_794073_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	4.81145e-120
NC_022226.1\|WP_001248939.1\|798921_799917_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NC_022226.1\|WP_000057543.1\|794573_796013_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.14043e-06
NC_022226.1\|WP_000369722.1\|798013_798925_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
NC_022226.1\|WP_000816300.1\|802364_803267_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	1.43426e-153
NC_022226.1\|WP_001049165.1\|801534_802122_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NC_022226.1\|WP_000538141.1\|785698_786349_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NC_022226.1\|WP_010956549.1\|783166_784277_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_022226.1\|WP_000958224.1\|792295_793228_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NC_022226.1\|WP_020978082.1\|786345_786582_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	5.48706e-34
NC_022226.1\|WP_000662681.1\|788843_791690_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NC_022226.1\|WP_000506531.1\|780320_782852_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0

>NC_022226.1|WP_000662681.1|788843_791690_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NC_022226.1|WP_000229238.1|786850_788836_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIEEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYRTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQIRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NC_022226.1|WP_020978082.1|786345_786582_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIVFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NC_022226.1|WP_000538141.1|785698_786349_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NC_022226.1|WP_000753321.1|784685_785525_+|CHAP-domain-containing-protein
MKKTLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKTPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NC_022226.1|WP_072360986.1|784430_784538_+|hypothetical-protein
MYLLKQHMQCAFSNITYGDFQGIELIVENVLNYMV
>NC_022226.1|WP_010956549.1|783166_784277_+|peptide-chain-release-factor-2
MELSEIKRNIDKYNQDLTQIRGSLDLENKETNIQEYEEMMAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDEEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDIGPFIESYLRQTMSHD
>NC_022226.1|WP_001790092.1|782893_782998_+|hypothetical-protein
MLWEESFYFTSVKYFKKCEEVVKRCYVLSFKKSV
>NC_022226.1|WP_000506531.1|780320_782852_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>NC_022226.1|WP_000617735.1|779334_779907_+|ribosome-associated-translation-inhibitor-RaiA
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
>NC_022226.1|WP_000958224.1|792295_793228_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NC_022226.1|WP_000513313.1|793233_794073_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYVENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NC_022226.1|WP_001224795.1|794080_794566_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLVGANSIILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NC_022226.1|WP_000057543.1|794573_796013_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYQNELFVSENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NC_022226.1|WP_000134961.1|796079_797015_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLKDQA
>NC_022226.1|WP_000369722.1|798013_798925_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NC_022226.1|WP_001248939.1|798921_799917_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NC_022226.1|WP_001049165.1|801534_802122_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NC_022226.1|WP_000816300.1|802364_803267_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGIILSNEGGALQTMKLPYEYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE
>NC_022226.1|WP_000070826.1|803969_804599_+|DUF4887-domain-containing-protein
MSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDKASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK

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Crispr_ID: NC_022226_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022226_4

1087469-1087561

Orphan

Consensus_repeat	Method
TCATAATGATTAAAAATCAAAGAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022226_4

>merge|NC_022226|4|1087469-1087561|CRISPRCasFinder
TCATAATGATTAAAAATCAAAGAGGAACAGCGGAATACAGATGATGCTTCGCATCACTGCATAAAAGCCTCTAATGATTAAAAATCAAAGAGG

>NC_022226|4|4|1087469-1087561|CRISPRCasFinder
TCATAATGATTAAAAATCAAAGAGG	AACAGCGGAATACAGATGATGCTTCGCATCACTGCATAAAAGC
CTCTAATGATTAAAAATCAAAGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022226.1\|WP_000079317.1\|1096707_1097322_+\|succinate-dehydrogenase-cytochrome-b558-subunit	unknown	unknown	gnl\|CDD\|239577
NC_022226.1\|WP_000435372.1\|1082537_1083278_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NC_022226.1\|WP_000003566.1\|1083657_1084716_+\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780
NC_022226.1\|WP_001249293.1\|1091443_1093792_+\|endonuclease-MutS2	unknown	unknown	gnl\|CDD\|234750
NC_022226.1\|WP_000046704.1\|1088860_1089127_+\|cell-division-protein-ZapA	unknown	unknown	gnl\|CDD\|172616
NC_022226.1\|WP_001246696.1\|1078086_1079163_+\|iron-regulated-surface-determinant-protein-IsdD	unknown	unknown	unknown
NC_022226.1\|WP_001788617.1\|1082190_1082298_+\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000670950.1\|1081830_1082154_+\|staphylobilin-forming-heme-oxygenase-IsdG	unknown	unknown	gnl\|CDD\|139480
NC_022226.1\|WP_000161940.1\|1089721_1091434_+\|DNA-polymerase/3'-5'-exonuclease-PolX	unknown	unknown	gnl\|CDD\|236311
NC_022226.1\|WP_001220199.1\|1079159_1080038_+\|heme-ABC-transporter-substrate-binding-protein-IsdE	unknown	unknown	gnl\|CDD\|274706
NC_022226.1\|WP_000818276.1\|1097373_1099140_+\|succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236319
NC_022226.1\|WP_001788625.1\|1094341_1094437_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000908978.1\|1084715_1087118_+\|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234804
NC_022226.1\|WP_000234068.1\|1089127_1089649_+\|CvpA-family-protein	unknown	unknown	gnl\|CDD\|224205
NC_022226.1\|WP_001018928.1\|1093964_1094279_+\|thioredoxin	unknown	unknown	gnl\|CDD\|200072
NC_022226.1\|WP_000139712.1\|1099139_1099955_+\|succinate-dehydrogenase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|181515
NC_022226.1\|WP_001242420.1\|1081077_1081812_+\|class-B-sortase	unknown	unknown	gnl\|CDD\|226898
NC_022226.1\|WP_000594528.1\|1080050_1081016_+\|hemin-ABC-transporter-permease-protein-IsdF	unknown	unknown	gnl\|CDD\|223682
NC_022226.1\|WP_000789821.1\|1077403_1078087_+\|heme-uptake-protein-IsdC	unknown	unknown	gnl\|CDD\|274705
NC_022226.1\|WP_000390524.1\|1094602_1096384_+\|excinuclease-ABC-subunit-UvrC	unknown	unknown	gnl\|CDD\|234792

Protein	Function_ID	Function_description	E-value
NC_022226.1\|WP_000435372.1\|1082537_1083278_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	2.00285e-77
NC_022226.1\|WP_000003566.1\|1083657_1084716_+\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NC_022226.1\|WP_001249293.1\|1091443_1093792_+\|endonuclease-MutS2	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	0
NC_022226.1\|WP_000046704.1\|1088860_1089127_+\|cell-division-protein-ZapA	gnl\|CDD\|172616	PRK14126, PRK14126, cell division protein ZapA; Provisional.	1.04877e-21
NC_022226.1\|WP_000139712.1\|1099139_1099955_+\|succinate-dehydrogenase-iron-sulfur-subunit	gnl\|CDD\|181515	PRK08640, sdhB, succinate dehydrogenase iron-sulfur subunit; Reviewed.	0
NC_022226.1\|WP_000670950.1\|1081830_1082154_+\|staphylobilin-forming-heme-oxygenase-IsdG	gnl\|CDD\|139480	PRK13312, PRK13312, staphylobilin-forming heme oxygenase IsdG.	3.35893e-67
NC_022226.1\|WP_000161940.1\|1089721_1091434_+\|DNA-polymerase/3'-5'-exonuclease-PolX	gnl\|CDD\|236311	PRK08609, PRK08609, DNA polymerase/3'-5' exonuclease PolX.	0
NC_022226.1\|WP_001220199.1\|1079159_1080038_+\|heme-ABC-transporter-substrate-binding-protein-IsdE	gnl\|CDD\|274706	TIGR03659, heme_ABC_transporter_heme-binding_protein_isdE, heme ABC transporter, heme-binding protein isdE. This family of ABC substrate-binding proteins is observed primarily in close proximity with proteins localized to the cell wall and bearing the NEAT (NEAr Transporter, pfam05031) heme-binding domain. IsdE has been shown to bind heme and is involved in the process of scavenging heme for the purpose of obtaining iron.	9.77537e-156
NC_022226.1\|WP_000818276.1\|1097373_1099140_+\|succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236319	PRK08641, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NC_022226.1\|WP_000079317.1\|1096707_1097322_+\|succinate-dehydrogenase-cytochrome-b558-subunit	gnl\|CDD\|239577	cd03497, SQR_TypeB_1_TM, Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis SQR reduces low potential quinones such as menaquinone. SQR is also called succinate dehydrogenase (Sdh) or Complex II and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type B as they contain one transmembrane subunit and two heme groups. The heme and quinone binding sites reside on the transmembrane subunit. The transmembrane subunit of Bacillus subtilis SQR is also called Sdh cytochrome b558 subunit. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit containing the electron acceptor (quinone). The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.	2.37018e-87
NC_022226.1\|WP_000908978.1\|1084715_1087118_+\|phenylalanine--tRNA-ligase-subunit-beta	gnl\|CDD\|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	0
NC_022226.1\|WP_000234068.1\|1089127_1089649_+\|CvpA-family-protein	gnl\|CDD\|224205	COG1286, CvpA, Uncharacterized membrane protein, required for colicin V production [General function prediction only].	4.13485e-29
NC_022226.1\|WP_001018928.1\|1093964_1094279_+\|thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	3.26685e-48
NC_022226.1\|WP_001242420.1\|1081077_1081812_+\|class-B-sortase	gnl\|CDD\|226898	COG4509, COG4509, Uncharacterized protein conserved in bacteria [Function unknown].	2.78558e-128
NC_022226.1\|WP_000594528.1\|1080050_1081016_+\|hemin-ABC-transporter-permease-protein-IsdF	gnl\|CDD\|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	1.20946e-60
NC_022226.1\|WP_000789821.1\|1077403_1078087_+\|heme-uptake-protein-IsdC	gnl\|CDD\|274705	TIGR03656, IsdC, heme uptake protein IsdC. Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, pfam05031) domain, which confers the ability to bind heme, and a C-terminal SrtB processing signal which targets the protein to the cell wall. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.	2.0626e-97
NC_022226.1\|WP_000390524.1\|1094602_1096384_+\|excinuclease-ABC-subunit-UvrC	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0

>NC_022226.1|WP_000908978.1|1084715_1087118_+|phenylalanine--tRNA-ligase-subunit-beta
MLISNEWLKEYVTIDDSVSNLAERITRTGIEVDDLIDYTKDIKNLVVGFVKSKEKHPDADKLNVCQVDIGEDEPVQIVCGAPNVDAGQYVIVAKVGGRLPGGIKIKRAKLRGERSEGMICSLQEIGISSNYIPKSFESGIYVFSEAQVPGTDALQALYLDDQVMEFDLTPNRADALSMIGTAYEVAALYNTKMTKPDTTSNELELSANNELTVTIENEDKVPYYSARVVHDVTIEPSPIWMQARLIKAGIRPINNVVDISNYVLLEYGQPLHMFDQDAIGSQQIVVRQANEGEKMTTLDGTERELLTSDIVITNGQTPIALAGVMGGDFSEVKEQTSNIVIEGAIFDPVSIRHTSRRLNLRSESSSRFEKGIATEFVDEAVDRACYLLQTYANGKVLKDRVSSGELGAFITPIDITADKINRTIGFDLSQNDIVTIFNQLGFDTEINDDVITVQVPSRRKDITIKEDLIEEVARIYGYDDIPSTLPVFEKVTSGQLTDRQYKTRMVKEVLEGAGLDQAITYSLVSKEDATAFSMQQRQTIDLLMPMSEAHASLRQSLLPHLIEAASYNVARKNKDVKLFEIGNVFFANGEGELPDQVEYLSGILTGDYVVNQWQGKKETVDFYLAKGIVDRVSEKLNLEFSYRRADIDGLHPGRTAEILLENKVVGFIGELHPTLAADNDLKRTYVFELNFDALMAVSVGYINYQPIPRFPGMSRDIALEVDQNIPAADLLSTIHAHGGNILKDTLVFDVYQGEHLEKGKKSIAIRLNYLDTEETLTDERVSKVQAEIEAALIEHGAVIR
>NC_022226.1|WP_000003566.1|1083657_1084716_+|phenylalanine--tRNA-ligase-subunit-alpha
MSEQQTMSELKQQALVDINEANDERALQEVKVKYLGKKGSVSGLMKLMKDLPNEEKPAFGQKVNELRQTIQNELDERQQMLVKEKLNKQLAEETIDVSLPGRHIEIGSKHPLTRTIEEIEDLFLGLGYEIVNGYEVEQDHYNFEMLNLPKSHPARDMQDSFYITDEILLRTHTSPVQARTMESRHGQGPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVDKNVKMSDLKGTLELLAKKLFGADREIRLRPSYFPFTEPSVEVDVSCFKCKGKGCNVCKHTGWIEILGAGMVHPNVLEMAGFDSSEYSGFAFGMGPDRIAMLKYGIEDIRHFYTNDVRFLDQFKAVEDRGDM
>NC_022226.1|WP_000435372.1|1082537_1083278_+|RNA-methyltransferase
MEQITSAQNNRIKQANKLKKKRERDKTGLALIEGVHLIEEAYQSGIVITQLFAIEPARLDQQIIAYAQEVFEINMKVAESLSGTVTPQGFFAIIEKPHYDISKAQQVLLIDRVQDPGNLGTLIRTADAAGMDAVIMEKGTTDPYQDKVLRASQGSVFHLPVMIQDLDTFITQFNGPVYGTALENAVAYKEVTSSDSFALLLGNEGEGVNPELLAHTTQNLIIPIYGKAESLNVAIAGSILLYHLKG
>NC_022226.1|WP_001788617.1|1082190_1082298_+|hypothetical-protein
MVLLAFVTTIHDTDDGRFFNEHKHANNKLLKHSLI
>NC_022226.1|WP_000670950.1|1081830_1082154_+|staphylobilin-forming-heme-oxygenase-IsdG
MKFMAENRLTLTKGTAKDIIERFYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHVRSKNEDESSPIINNKVITYDIGYSYMK
>NC_022226.1|WP_001242420.1|1081077_1081812_+|class-B-sortase
MRMKRFLTIVQILLVVIIIIFGYKIVQTYIEDKQERANYEKLQQKFQMLMSKHQAHVRPQFESLEKINKDIVGWIKLSGTSLNYPVLQGKTNHDYLNLDFEREHRRKGSIFMDFRNELKNLNHNTILYGHHVGDNTMFDVLEDYLKQSFYEKHKIIEFDNKYGKYQLQVFSAYKTTTKDNYIRTDFENDQDYQQFLDETKRKSVINSDVNVTVKDRIMTLSTCEDAYSETTKRIVVVAKIIKVS
>NC_022226.1|WP_000594528.1|1080050_1081016_+|hemin-ABC-transporter-permease-protein-IsdF
MIKNKKKLLFLCLLVILIATAYISFVTGTIKLSFNDLFTKFTTGSNEAVDSIIDLRLPRILIALMVGAMLAVSGALLQAALQNPLAEANIIGVSSGALIMRALCMLFIPQLYFYLPLLSFIGGLIPFLIIILLHSKFRFNAVSMILVGVALFVLLNGVLEILTQNPLMKIPQGLTMKIWSDVYILAVSALLGLILTLLLSPKLNLLNLDDIQARSIGFNIDRYRWLTGLLAVFLASATVAIVGQLAFLGIIVPHVVRKLVGGNYRVLIPFSTVIGAWLLLVADLLGRVIQPPLEIPANAILMIVGGPMLICLICQSQRNRI
>NC_022226.1|WP_001220199.1|1079159_1080038_+|heme-ABC-transporter-substrate-binding-protein-IsdE
MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTSYKTLPNRYKDVPEIGQPMEPNVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFDSLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKAAKQKKHPKVLILMGVPGSYLVATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMPEEVKKMFQKEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK
>NC_022226.1|WP_001246696.1|1078086_1079163_+|iron-regulated-surface-determinant-protein-IsdD
MRNVKQIATKSIIAIISLGILTYTTMIGSVLADEIKYPSAKFNQPEAKDKTELTTSIFDEKIKENKALELLIFNQENKNVTEEQKLVDEKAQLISDMTGKIYLQVKLKGQIDKEQLVFQNDKNEEFPFVIKDEKDDTIVRILIEQHMDKINMHVKTLAEKKNLDNKEMVYSIHFKEKKVQHDDAKEVPSKHQNQENNQDQLKKDIDDKKDSQKSDTKERRTSLFTEKGLNDIPVQKDKVQQDSNKKIENERPKASGTLKVENSPPTIKKVENNHKEQPKHKDEKSKKEKKKVVEKEKALPAFNRDDDSKNSSQLSSDIKELDEPNHKKQYILFAAGIVLATILLISAHLYSRKRGNQV
>NC_022226.1|WP_000789821.1|1077403_1078087_+|heme-uptake-protein-IsdC
MKNILKVFNTTILALIIIIATFSNSANAADSGTLNYEVYKYNTNDTSIANDYFNKPAKYIKKNGKLYVQITVNHSHWITGMSIEGHKENIISKNTAKDERTSEFEVSKLNGKIDGKIDVYIDEKVNGKPFKYDHHYNITYKFNGPTDVAGANAPGKDDKNSASGSDKGSDGTTTGQSESNSSNKDKVENPQTNAGTPAYIYAIPVASLALLIAITLFVRKKSKGNVE
>NC_022226.1|WP_000046704.1|1088860_1089127_+|cell-division-protein-ZapA
MAQFKNKVNVSINDQLFTIVGEDNPEHIRYVAHLVDDKIKELGYKAAGLDTSRKAILTAVNIMHEKVLLEEENRRLKQQIHKLQQREQ
>NC_022226.1|WP_000234068.1|1089127_1089649_+|CvpA-family-protein
MVIDFIIIIFFVYFVIVGFRRGFWLSMIHLSATIVSLWIASQFYKSIVERLIVFIPYPKTTAFNTTFAFHFNHLQNRFEAIVAFLMITLFCKFILYLIIVTFDKIIAYQNIHIFSRAMGMIVGVFMTIIVLHFTLYLLALYPNEALQHQLKISIVSHSLIFHIPYLSAFTINL
>NC_022226.1|WP_000161940.1|1089721_1091434_+|DNA-polymerase/3'-5'-exonuclease-PolX
MTKKDVIKLLEQIATYMELKGENTFKISAYRKAAQSLELDERPLDEISDVTELKGIGKGVAEVINDYRETGESQYLQQLQEEVPEGLIPLLKIQGLGSKKIAKLYKELNIVDKASLQVACENGKVSELSGFAKKTEQNILEAVKQLGAKKDRYPIDQMRRLNQEIIDYIDTLNYIDQYSSAGSFRRFKEMSKDLDFIISTDNPKAVQQQLLNIPNKVKEVAVGNTKVSLELAYDDETIGVDFRLIEPSAFYHTLQHFTGSKEHNIRIRQLAKARDEKVSEYGIEQADGTLIQYDSEAKIYEHFNVNFIPPAMREDGSEFDKDLSNIITIDDINGDIHMHTTYSDGAFSIRDMVEANIAKGYKFMVITDHSQSLRVANGLQVERLLRQNEEIKALDKEYSEIDIYSGTEMDILPDGSLDYDDEILAQLDYVIGAIHQSFNQSEEQIMERLANACRNPYVRHIAHPTGRIIGRRDGYKPNIEQLMALAEETNTVLEINANPHRLDLNADIVRKYPNVKLTINTDAHHTNHLDFMNYGVATAQKGFVTKDRVINALSREAFKDFIENNIKLKK
>NC_022226.1|WP_001249293.1|1091443_1093792_+|endonuclease-MutS2
MRQKTLDVLEFEKIKSLVANETISDLGLEKVNQMMPATNFETVVFQMEETDEIAQIYNKHRLPSLSGLSKVSAFIHRADIGGVLNVSELNLIKRLIQVQNQFKTFYNQLVEEDEGVKYPILDDKMNQLPVLTDLFQQINETCDTYDLYDNASYELQGIRSKISSTNQRIRQNLDRIVKSQANQKKLSDAIVTVRNERNVIPVKAEYRQDFNGIVHDQSASGQTLYIEPSSVVEMNNQISRLRHDEAIEKERILTQLTGYVAADKDALLVAEQVMGQLDFLIAKARYSRSIKGTKPIFKEERTVYLPKAYHPLLNRETVVANTIEFMEDIETVIITGPNTGGKTVTLKTLGLIIVMAQSGLLIPTLDGSQLSVFKNVYCDIGDEQSIEQSLSTFSSHMTNIVEILKHADKHSLVLFDELGAGTDPSEGAALAMSILDHVRKIGSLVMATTHYPELKAYSYNREGVMNASVEFDVDTLSPTYKLLMGVPGRSNAFDISKKLGLSLNIINKAKTMIGTDEKEINEMIESLERNYKRVETQRLELDRLVKEAEQVHDDLSKQYQQFQNYEKSLIEEAKEKANQKIKAATKEADDIIKDLRQLREQKGADVKEHELIDKKKRLDDHYEAKSIKQNVQKQKYDKIVAGDEVKVLSYGQKGEVLEIVNDEEAIVQMGIIKMKLPIEDLEKKQKEKVKPTKMVTRQNRQTIKTELDLRGYRYEDALIELDQYLDQAVLSNYEQVYIIHGKGTGALQKGVQQHLKKHKSVSDFRGGMPSEGGFGVTVATLK
>NC_022226.1|WP_001018928.1|1093964_1094279_+|thioredoxin
MAIVKVTDADFDSKVESGVQLVDFWATWCGPCKMIAPVLEELAADYEGKADILKLDVDENPSTAAKYEVMSIPTLIVFKDGQPVDKVVGFQPKENLAEVLDKHL
>NC_022226.1|WP_001788625.1|1094341_1094437_-|hypothetical-protein
MLDYHLTFIDLLIPPFSSRKQYDDLSFNFLY
>NC_022226.1|WP_000390524.1|1094602_1096384_+|excinuclease-ABC-subunit-UvrC
MEDYKQRIKNKLNVVPMEPGCYLMKDRNDQVIYVGKAKKLRNRLRSYFTGAHDAKTTRLVGEIRRFEFIVTSSETESLLLELNLIKQYQPRYNILLKDDKSYPFIKITKEKYPRLLVTRTVKQGTGKYFGPYPNAYSAQETKKLLDRIYPYRKCDKMPDKLCLYYHIGQCLGPCVYDVDLSKYAQMTKEITDFLNGEDKTILKSLEERMLTASESLDFERAKEYRDLIQHIQNLTNKQKIMSSDKTIRDVFGYCVDKGWMCIQVFFIRQGNMIKRDTTMIPLQQTEEEEFYTFIGQFYSLNQHILPKEVHVPRNLDKEMIQSVVDTKIVQPARGPKKDMVDLAAHNAKVSLNNKFELISRDESRTIKAIEELGTQMGIQTPIRIEAFDNSNIQGVDPVSAMVTFVDGKPDKKNYRKYKIKTVKGPDDYKSMREVVRRRYSRVLNEGLPLPDLIIVDGGKGHMNGVIDVLQNELGLDIPVAGLQKNDKHQTSELLYGASAEIVPLKKNSQAFYLLHRIQDEVHRFAITFHRQTRQKTGLKSILDDIDGIGNKRKTLLLRSFGSIKKMKEATLEDFKNIGIPENVAKNLHEQLHK
>NC_022226.1|WP_000079317.1|1096707_1097322_+|succinate-dehydrogenase-cytochrome-b558-subunit
MAQSKNEFYLRRIHSLLGIIPIGAFLVVHLLVNHQATQGAEAFNKASNFMESLPFLIIVEFLFIYIPLLYHGLFGIHIAFTAKENVGHYSIFRNWMFFFQRVSGILTFIFIGIHLWQTRLQKAFYGKEVNYDLMHETLQHPGWAIFYIICIIAVVFHFANGLWSFLVTWGGLQSPKSQRVFTWVSLIVFLVISYIGVTAIIAFM
>NC_022226.1|WP_000818276.1|1097373_1099140_+|succinate-dehydrogenase-flavoprotein-subunit
MAEKHLIVVGGGLAGLMSTIKAAEKGAHVDLFSVVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTVYGGDFLANQPPVKAMTEAAPKIIHLLDRMGVMFNRTNEGLLDFRRFGGTLHHRTAYAGATTGQQLLYALDEQVRAFEVDGLVTKYEGWEFLGIVKGDDDSARGIVAQNMTTAEIETFGSDAVIMATGGPGIIFGKTTNSMINTGSAASIVYQQGAIYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRIWTYKDGKPWYFLEEKYPDYGNLVPRDIATREIFDVCINQKLGINGENMVYLDLSHKDPHELDVKLGGIIEIYEKFTGDDPRKVPMKIFPAVHYSMGGLYVDYDQMTNIKGLFAAGECDFSQHGGNRLGANSLLSAIYGGTVAGPNAIDYISNIDRSYTDMDESIFEKRKAEEQERFDKLLAMRGTENAYKLHRELGEIMTANVTVVRENEKLLETDKKIVELMKRYEDIDMEDTQTWSNQAVFFTRQLWNMLVLARVITIGAYNRNESRGAHYKPEFPERNDEEWLKTTMASFQGAFEKPQFTYDDVDVSLIPPRKRDYTSKSKGGKK
>NC_022226.1|WP_000139712.1|1099139_1099955_+|succinate-dehydrogenase-iron-sulfur-subunit
MTEQSVKNTPQHETQSKPKQKTVKLIIKRQDTSDSKPYEETFEIPYRENLNVIACLMEIRRNPVNIKGEKTTPVVWDMNCLEEVCGACSMVINGRARQSCSAIVDQLEQPIRLEPMNTFPVIRDLQVDRSRMFDNLKRMKAWIPIDGTYDLGPGPRMPEKKRQTAYELSKCMTCGVCLEVCPNVTENNKFVGAQAISQVRLFNLHPTGSMTKDERLNALMGTGGLQQCGNSQNCVNACPKGIPLTTSIAAMNRETTFHMFKSFFGSDHEVE

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Click the colored protein region to show detailed information

Crispr_ID: NC_022226_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022226_5

1868470-1868551

Orphan

Consensus_repeat	Method
TGCAAGTTGGCGGGGCCACAACATAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022226_5

>merge|NC_022226|5|1868470-1868551|CRISPRCasFinder
TGCAAGTTGGCGGGGCCACAACATAGTGGAATTGGATTCCCAATTTCTACAGACATTGCAAGTTGGCGAGGCCACAACATAG

>NC_022226|5|5|1868470-1868551|CRISPRCasFinder
TGCAAGTTGGCGGGGCCACAACATAG	TGGAATTGGATTCCCAATTTCTACAGACAT
TGCAAGTTGGCGAGGCCACAACATAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022226.1\|WP_000992523.1\|1860876_1862001_-\|DUF445-domain-containing-protein	unknown	unknown	gnl\|CDD\|226834
NC_022226.1\|WP_000649907.1\|1872405_1873863_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
NC_022226.1\|WP_000869449.1\|1884485_1885436_-\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240632
NC_022226.1\|WP_000063582.1\|1874120_1875182_-\|PTS-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226167
NC_022226.1\|WP_029160281.1\|1870412_1871540_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	unknown	unknown	gnl\|CDD\|272993
NC_022226.1\|WP_000901023.1\|1867774_1868170_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000031108.1\|1869003_1869156_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_001251229.1\|1869180_1869780_-\|glucosamine-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223440
NC_022226.1\|WP_020978250.1\|1858385_1859582_-\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
NC_022226.1\|WP_000181394.1\|1869937_1870408_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	unknown	unknown	gnl\|CDD\|223297
NC_022226.1\|WP_001045133.1\|1862999_1863623_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NC_022226.1\|WP_000939521.1\|1885441_1885897_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NC_022226.1\|WP_000375864.1\|1862179_1862644_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224393
NC_022226.1\|WP_000116231.1\|1866193_1867579_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NC_022226.1\|WP_000437968.1\|1863644_1864757_-\|GAF-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_022226.1\|WP_000290301.1\|1860463_1860808_-\|YlbF/YmcA-family-competence-regulator	unknown	unknown	gnl\|CDD\|237467
NC_022226.1\|WP_001802255.1\|1859872_1859971_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000590809.1\|1871690_1872413_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_022226.1\|WP_000110011.1\|1883942_1884389_-\|peroxide-responsive-transcriptional-repressor-PerR	unknown	unknown	gnl\|CDD\|223806
NC_022226.1\|WP_000669376.1\|1864919_1865741_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638

Protein	Function_ID	Function_description	E-value
NC_022226.1\|WP_000992523.1\|1860876_1862001_-\|DUF445-domain-containing-protein	gnl\|CDD\|226834	COG4399, COG4399, Uncharacterized protein conserved in bacteria [Function unknown].	4.6883e-165
NC_022226.1\|WP_000649907.1\|1872405_1873863_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.14709e-98
NC_022226.1\|WP_000869449.1\|1884485_1885436_-\|phosphoglycerate-dehydrogenase	gnl\|CDD\|240632	cd12155, PGDH_1, Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family. Phosphoglycerate Dehydrogenase (PGDH) catalyzes the NAD-dependent conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first step in serine biosynthesis. Over-expression of PGDH has been implicated as supporting proliferation of certain breast cancers, while PGDH deficiency is linked to defects in mammalian central nervous system development. PGDH is a member of the 2-hydroxyacid dehydrogenase family, enzymes that catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	3.25267e-136
NC_022226.1\|WP_000063582.1\|1874120_1875182_-\|PTS-transporter-subunit-IIC	gnl\|CDD\|226167	COG3641, PfoR, Predicted membrane protein, putative toxin regulator [General function prediction only].	2.31644e-122
NC_022226.1\|WP_000437968.1\|1863644_1864757_-\|GAF-domain-containing-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	7.65897e-57
NC_022226.1\|WP_001045133.1\|1862999_1863623_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.11819e-78
NC_022226.1\|WP_020978250.1\|1858385_1859582_-\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	4.52716e-63
NC_022226.1\|WP_000181394.1\|1869937_1870408_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	gnl\|CDD\|223297	COG0219, CspR, Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis].	1.70324e-88
NC_022226.1\|WP_001251229.1\|1869180_1869780_-\|glucosamine-6-phosphate-isomerase	gnl\|CDD\|223440	COG0363, NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism].	6.38527e-11
NC_022226.1\|WP_000939521.1\|1885441_1885897_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	1.44283e-68
NC_022226.1\|WP_000375864.1\|1862179_1862644_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	5.18868e-15
NC_022226.1\|WP_000116231.1\|1866193_1867579_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NC_022226.1\|WP_029160281.1\|1870412_1871540_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	gnl\|CDD\|272993	TIGR00276, iron-sulfur_cluster-binding_protein, epoxyqueuosine reductase. This model was rebuilt to exclude archaeal homologs, now that there is new information that bacterial members are epoxyqueuosine reductase, QueG, involved in queuosine biosynthesis for tRNA maturation. [Protein synthesis, tRNA and rRNA base modification].	2.34756e-178
NC_022226.1\|WP_000290301.1\|1860463_1860808_-\|YlbF/YmcA-family-competence-regulator	gnl\|CDD\|237467	PRK13676, PRK13676, YlbF/YmcA family competence regulator.	1.19759e-37
NC_022226.1\|WP_000590809.1\|1871690_1872413_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.70748e-153
NC_022226.1\|WP_000110011.1\|1883942_1884389_-\|peroxide-responsive-transcriptional-repressor-PerR	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	6.09298e-56
NC_022226.1\|WP_000669376.1\|1864919_1865741_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	3.35529e-78

>NC_022226.1|WP_000901023.1|1867774_1868170_-|hypothetical-protein
MLGKYWIQLLIATVIISLISIKAFPLAIGALYLPVIFKVIKLQLNLSKGLIDDVNAQTFIKSNQSGIVISVICCLLITGILYYTLDGFYASLTGVLGTLVALNPYTTIVSAVLYILTAIATVEATKTKYRN
>NC_022226.1|WP_000116231.1|1866193_1867579_-|class-II-fumarate-hydratase
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFDLGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFDSIIKIGRTHLQDATPIKLGQEISGWRYMLDRCEIMLSESKKHILNLAIGGTAVGTGINAHPEFGDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
>NC_022226.1|WP_000669376.1|1864919_1865741_+|RluA-family-pseudouridine-synthase
MKFKIPENFNDLSLRDIFQQLKVPKKDLHHLNMSKDITINDKPARLMDKVHTGDDVFVPTIDEKSNYVPSYRYAQIKYEDDDMAIVMKPKGVKTHPNDLKESNTLMNHVIYTIDSDYVEPIHRLDQETVGLLIVAKNPLMKKILDRMLEDNDITRIYKANVKALLPLKPQTIDMPIGKDKFHSNKRRVSPTGQRAITHILTSKMIKEAVCQLEIKLDTGRTHQIRVHLAEIGHPVIGDPLYGDSTLRQLELESYKIEFVHPLTKEVISVSLDD
>NC_022226.1|WP_000437968.1|1863644_1864757_-|GAF-domain-containing-sensor-histidine-kinase
MEQRTRLALLKEIAEFLNEETEMYSMTQGALKYLIEGSNFTTGWIFFINSVGEHELVSHVALPQSLTADHCHYIKDGSCWCVKAFNQRRLMKASNIVNCSRINLASKAFPSQNDNITHHATVPLKSGQEQFGILNVASPNTEIYSDEDLELLESVAFQLGSAIKRIYLTDREKEAAKINERNRLARDLHDSVNQMLFSVKLTAHAAYGMSNESIAKQAFKTIEETSQNAVNEMRALIWQLKPVGLEQGLIHALTAYSKLMHIQLNVNVEGLIDLSNEIEENIYRALQECINNVKKHADTNKMDLTLKQMNDILYIDVIDYGQGFEIDNVQIASSHGINNIKQRVKLLRGRVTFHSQPTKGTQIQFTIPIK
>NC_022226.1|WP_001045133.1|1862999_1863623_-|response-regulator-transcription-factor
MNKVILVDDHYIVRQGLRFLLSTIENIEVLQDFADGETFLEYLKEHEHPDIVLLDLVMPGMNGIEITEYIKAHYPDIKVLVLTSYVDDEHVISAINKGADGYEMKDVEPQQLIETIRRVMNGEKMIHPKAQDVFETVSQKPHYTNKLSKREIEVLREMVKGKTNKEIAETLFVSEKTIKTHVSHIFSKLQVSDRTQAAIYAMENKLI
>NC_022226.1|WP_000375864.1|1862179_1862644_-|helix-turn-helix-transcriptional-regulator
MDRQSFTDLIQTKFKMVRIEAGYTQDTMAQTIGLSKKTLVQIEKERVLPNWTTCISICALFRDSEVLNSTFGCDPLEIVQTISRNHCAYPNHAPTSDIYWNNIETRNGYILQSNKVSNIYRVLNPDNQPIFGTSKMREAETYFNRNAKEELVHI
>NC_022226.1|WP_000992523.1|1860876_1862001_-|DUF445-domain-containing-protein
MNALFIIIFMIVVGAIIGGITNVIAIRMLFHPFKPYYIFKFRVPFTPGLIPKRREEIATKIGQVIEEHLLTETLINEKLKSEQSQQAIESMIQQQLQKLTKDQLSIKQITSQIDIDLEQVLQTNGNQYIESQLNNYYTKHQNQTIASLLPNQLVTFLDQHVDNATDLLCDRARNYLSSAKGTQDINDMLDTFFNEKGKLIGMLQMFMTKESIADRIQQELIRLTSHPKARTIVTSLITNEYQTFKDKPLNELLDASQFNEIAENLSVYITTYASKQANKPVVTLMPQFVDYLEGQLSSKLANLIIEQLSIHLSTIMKKVDLRGLIEEQINTFDLDYIEKLIIEIANKELKLIMSLGFILGGIIGFFQGLVAIFV
>NC_022226.1|WP_000290301.1|1860463_1860808_-|YlbF/YmcA-family-competence-regulator
MAVNLYDYANQLEQALRESEEYKAIKEAFANVKANEESKKLFDEFRETQINFQQKQMQGEEIAEEDLQKAQEQAQAIEKDENISALMNAEQKMSQVFQEINQIIVKPLDEIYAD
>NC_022226.1|WP_001802255.1|1859872_1859971_-|hypothetical-protein
MSVGSLAVLTITEIAFPTEIFEKNQRTLQIKF
>NC_022226.1|WP_020978250.1|1858385_1859582_-|exonuclease-SbcCD-subunit-D
MVKFIHCSDLHLDSPFKSKGHISPKIFEDVQKSAYESFKNIVDIALQQDVDFVIIAGDLFDSENRTLRAEIFLKQQFERLQNEQIFVYVCHGNHDPLSSKISSNWPDNVSVFSNKVETYEAITKSGETIYIHGFSYENRASYENKIDEYPSSQGQKGIHIGVLHGTYSKSSVNERYTEFILEDLNSKLYHYWALGHIHERQQLSDMPVINYSGNIQGRHFNEQGEKGCLLIEGDHLKLKTKFYPTQYIRFEEATIETDKTSKQGLYEVIQNFKEQVREEGKAFYRLTLVINSETLISPQDLLQVEEMITDYEENENQFVYIDELKVQYAQNDESPLVNEFSAELLVDQTVFDKAMSDLYLNPRASKFLDDYGTFDHTALVNRAEEILKAEMRGEQNDN
>NC_022226.1|WP_000031108.1|1869003_1869156_-|hypothetical-protein
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
>NC_022226.1|WP_001251229.1|1869180_1869780_-|glucosamine-6-phosphate-isomerase
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEGLGVPAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGKTSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
>NC_022226.1|WP_000181394.1|1869937_1870408_-|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL
MTNHIVLYQPEIPANTGNIARTCAGTNTHLHLIKPLGFRTDDKMLKRAGLDYWEFVNITYHDSIEAFFEATNGEYYLLTKFGKKTYSDFDFSNHDKDFYFIFGKETTGLPDWVKEKYQDTALRIPMSEHIRSLNLSNTAALLIYEALRQQDFPGLN
>NC_022226.1|WP_029160281.1|1870412_1871540_-|tRNA-epoxyqueuosine(34)-reductase-QueG
MDTKQLKQDIIDYAYTIGIDSIGFTTADRFDELKQKLEAYHANGYASGFEESDIALRTEPKLSLPTARSIIAIAVGYPNKLKGAPKSVRGDRRGLFARASWGQDYHTIMRKRLDMLASFIESKVPDVEIKSMVDTGVLSDRAVAERAGLGFVGRNGFVINPKLGTWTYLGEMLVSIPFEPDDPLLDSCGDCTICVDRCPTSALVGNGQLNSQKCISFLTQTKGYMPDQYRYKIGNRLYGCDTCQQVCPKNRGINTEQDDIILEPEILKPRLVPLLRMSNKEFKQTYGHLAGAWRGKKPIQRNAILALAHFNEVDAIPELKKVAITDERPMIRATAYWAIGQILGEEARDFINANYDQEDAEVQNEMIKGLDTRRE
>NC_022226.1|WP_000590809.1|1871690_1872413_-|amino-acid-ABC-transporter-ATP-binding-protein
MIKINNLNKVFGDNEVLKDINLEINQGEVVAIIGPSGSGKSTLLRCMNLLEVPTKGQVIFEGNDLTEKGTQVDKLRQKMGMVFQNFNLFPHKKVVDNIILAPKLLKKDNNDELHKEALSLLDKVGLKEKADVYPNQLSGGQKQRVAIARALAMHPDVILFDEPTSALDPEVVGDVLKVMKDLAKEGMTMVVVTHEMGFAKDVSDKVIFMADGVVVESGTPVEIFEQPQHERTQNFLARVL
>NC_022226.1|WP_000649907.1|1872405_1873863_-|ABC-transporter-permease-subunit
MKCLIRFILVLGLLISSAMVYINPTAHAEQDQTWEKIKERGELRVGLSADYAPMEFEHTVNGKTEYAGVDIDLAKKIAKDNNLKLKIVNMSFDSLLGALKTGKIDIIISGMTSTPERKKQVDFSDSYMMTKNIMLVKKDKVNEYKDIKDFNNKKVGAQKGTEQEKIAQTEIENASITSLSRLPDVILALKSGKVEGAVVEKPVAEAYLKQNPKLGISNVKFNEEEKDTVIAVPKDSPKLLSQINKTIKEVKDKGLIDKYMTNAANAMNDDSGFISKYGSFFLKGIKITILISLIGVALGSILGAFVALMKLSKIKIISWIASIYIEILRGTPMLVQVFIVFFGITAALGLDISALVCGTIALVINSSAYIAEIIRAGINAVDKGQMEAARSLGLNYRQTMKSVIMPQAIKNILPALGNEFVTLIKESSIVSTIGVGEIMFNAQVVQGISFDPFTPLIVAAALYFVLTFVLTRIMNMIEGRLNASD
>NC_022226.1|WP_000063582.1|1874120_1875182_-|PTS-transporter-subunit-IIC
MSNANNADNKQFFSKILNSIGAGVVIALVPNALLGEVLKIFKSGNEILELTYQLVILIQSFMAFIIGVLAAHQFKFNGAGAAIVGTSAMIGSGAVVYSNNSFMLKGIGDIINTSLVVIIACLIYMVLQNKLGSFELIILPVLVPIVSGGIGLITLPYIRKITQAIGNVIHSFTDLNPLLMSILISVAFSLLMVTPISLVAIATAISLNGLGSGAANLGIVAACVTFLFGSLRVNSIGVNAVLLIGAAKMMIPVYLKNLIISIPLTINGIITGIIAYVLQVKGTPLSAGFGYTGLVGPINAFNRMSGDPTMNIILLALGYFVIPFVSAFIVHELCKKFIPIYSNDIYKFEVPKQ
>NC_022226.1|WP_000110011.1|1883942_1884389_-|peroxide-responsive-transcriptional-repressor-PerR
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK
>NC_022226.1|WP_000869449.1|1884485_1885436_-|phosphoglycerate-dehydrogenase
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLQRCPNLKWIAWFATGVNTLPLDYIADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEAVLIEVLKSKVIRHAYLDVFENEPLKPNHELYELENVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGLIENEVDAKKGY
>NC_022226.1|WP_000939521.1|1885441_1885897_-|thioredoxin-dependent-thiol-peroxidase
MLQKGEQFPIFKLENQDGTVITNDTLKGKKAIIYFYPRDNTPTCTTEACDFRDNLEMFNDLDVAVYGISGDSKKKHQNFIEKHGLNFDLLVDEDFKLAKETGVYQLKKSFGKESMGIVRTTFIIDEQGKVLDVIEKVKVKTQIEELKNILG

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Crispr_ID: NC_022226_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022226_6

1909975-1910055

Orphan

Consensus_repeat	Method
TCTATGTTGGGGCCCCGCCAACCTG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NC_022226_6

>merge|NC_022226|6|1909975-1910055|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACCTGCACATTATCGTAAGCTGACTTTTCGTCAGCTTCTGTGTTGGGGCCCCGCCAACCTG

>NC_022226|6|6|1909975-1910055|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACCTG	CACATTATCGTAAGCTGACTTTTCGTCAGCT
TCTGTGTTGGGGCCCCGCCAACCTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022226.1\|WP_001789555.1\|1902100_1903357_-\|aminopeptidase	unknown	unknown	gnl\|CDD\|376723
NC_022226.1\|WP_001250329.1\|1913111_1914425_-\|lipid-II-isoglutaminyl-synthase-subunit-MurT	unknown	unknown	gnl\|CDD\|223840
NC_022226.1\|WP_025173836.1\|1911740_1912154_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_001790257.1\|1912182_1912293_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000228666.1\|1903706_1904171_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NC_022226.1\|WP_000548781.1\|1917544_1918075_-\|DUF3267-domain-containing-protein	unknown	unknown	gnl\|CDD\|378690
NC_022226.1\|WP_000180460.1\|1903359_1903560_-\|DUF1128-family-protein	unknown	unknown	gnl\|CDD\|227177
NC_022226.1\|WP_000140181.1\|1916227_1917298_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
NC_022226.1\|WP_001017131.1\|1906678_1907722_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NC_022226.1\|WP_000949467.1\|1914716_1915217_+\|H-type-ferritin-FtnA	unknown	unknown	gnl\|CDD\|224445
NC_022226.1\|WP_000636142.1\|1909037_1909796_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NC_022226.1\|WP_001110179.1\|1908434_1908821_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000153530.1\|1906059_1906689_-\|two-component-system-response-regulator-VraR	unknown	unknown	gnl\|CDD\|225107
NC_022226.1\|WP_001790679.1\|1915298_1915391_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000428172.1\|1904177_1904453_+\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000037079.1\|1904730_1905948_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|224214
NC_022226.1\|WP_000613738.1\|1915606_1916161_+\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NC_022226.1\|WP_000544965.1\|1912378_1913110_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NC_022226.1\|WP_000999714.1\|1910323_1911310_+\|aromatic-acid-exporter-family-protein	unknown	unknown	gnl\|CDD\|226614
NC_022226.1\|WP_000149064.1\|1907718_1908420_-\|cell-wall-active-antibiotics-response-protein	unknown	unknown	gnl\|CDD\|227100

Protein	Function_ID	Function_description	E-value
NC_022226.1\|WP_001789555.1\|1902100_1903357_-\|aminopeptidase	gnl\|CDD\|376723	pfam02073, Peptidase_M29, Thermophilic metalloprotease (M29).	0
NC_022226.1\|WP_001250329.1\|1913111_1914425_-\|lipid-II-isoglutaminyl-synthase-subunit-MurT	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	3.37755e-99
NC_022226.1\|WP_000140181.1\|1916227_1917298_-\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NC_022226.1\|WP_000228666.1\|1903706_1904171_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	3.39151e-65
NC_022226.1\|WP_000548781.1\|1917544_1918075_-\|DUF3267-domain-containing-protein	gnl\|CDD\|378690	pfam11667, DUF3267, Putative zincin peptidase. This family of proteins has a conserved HEXXH motif, suggesting the members are putative peptidases of zincin fold.	1.4991e-11
NC_022226.1\|WP_000180460.1\|1903359_1903560_-\|DUF1128-family-protein	gnl\|CDD\|227177	COG4840, COG4840, Uncharacterized protein conserved in bacteria [Function unknown].	9.24488e-25
NC_022226.1\|WP_001017131.1\|1906678_1907722_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.78722e-72
NC_022226.1\|WP_000949467.1\|1914716_1915217_+\|H-type-ferritin-FtnA	gnl\|CDD\|224445	COG1528, Ftn, Ferritin-like protein [Inorganic ion transport and metabolism].	4.6035e-74
NC_022226.1\|WP_000636142.1\|1909037_1909796_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	1.9498e-126
NC_022226.1\|WP_000613738.1\|1915606_1916161_+\|3'-5'-exonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	4.39188e-75
NC_022226.1\|WP_000153530.1\|1906059_1906689_-\|two-component-system-response-regulator-VraR	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.91794e-79
NC_022226.1\|WP_000037079.1\|1904730_1905948_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|224214	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair].	3.59491e-85
NC_022226.1\|WP_000544965.1\|1912378_1913110_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	2.14444e-120
NC_022226.1\|WP_000999714.1\|1910323_1911310_+\|aromatic-acid-exporter-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	5.31001e-76
NC_022226.1\|WP_000149064.1\|1907718_1908420_-\|cell-wall-active-antibiotics-response-protein	gnl\|CDD\|227100	COG4758, COG4758, Predicted membrane protein [Function unknown].	9.42019e-79

>NC_022226.1|WP_000636142.1|1909037_1909796_-|type-I-methionyl-aminopeptidase
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
>NC_022226.1|WP_001110179.1|1908434_1908821_-|hypothetical-protein
MNYVERYIEQFLRATVRNNIKHYLLMLDEKMKNLDDYMRYLITKKEQLSKLIDSLMLTLENKYIDIAEAFQIQCAREINNQEIENIKSELNKVEAYYAQIETQIQQTSTEKIATEKTSYLINYMNAVA
>NC_022226.1|WP_000149064.1|1907718_1908420_-|cell-wall-active-antibiotics-response-protein
MTHKYISTQMLIIFTALMIIANFYYIFFEKIGFLLVLLLGCVLVYVGYLYFHKIRGLLAFWIGALLIAFTLLSNKYTIIILFVFLLLLIVRYLIHKFKPKKVVATDEVMTSPSFIKQKWFGEQRTPVYVYKWEDVQIQHGIGDLHIDLTKAANIKENNTIVVRHILGKVQVILPVNYNINLHVAAFYGSTYVNEKSYKVENNNIHIEEMMKPDNYTVNIYVSTFIGDVEVIYR
>NC_022226.1|WP_001017131.1|1906678_1907722_-|sensor-histidine-kinase
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKTQIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVSQQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEIQDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGATFHIVSLPDSGTRIEVKAPLNKEDSYDD
>NC_022226.1|WP_000153530.1|1906059_1906689_-|two-component-system-response-regulator-VraR
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
>NC_022226.1|WP_000037079.1|1904730_1905948_+|YihY/virulence-factor-BrkB-family-protein
MSKKDHSSSKYLNSVKEAQEESKKKNKSNPKIDVDRTYIEPQQFQSKKPKKDDQVFFLSRLNKPAKYKKDSNFLSYLIYRIGKDDASGLAAQMTYHFVLAMFPMLLFLLTLLPFFNIKQSQITNMLSNAPAETSTLIKSVIGDITQNSSGGLLSIGLILAIWSASNGMTAIMNSFNVAYDVEDSRNGIVLKLLSVVFTVVMGVVFVVALALPTLGSVISHFLFGPLGFDEQVKWIFNLIRIVLPIIIIFIVFIVLYSVAPNVKTKLKSVLPGAVFTSIIWLAGSFGFGWYISNFGNYSKTYGSIAGIIILLLWLYITSFIIIVGAEINAIIHQRSVIKGKTPEEAALEHDDNNKNHYNENTRYEYDEDSNATHQRTYHVDEHPSDTYPEDDKNIKDKIVDKLKKD
>NC_022226.1|WP_000428172.1|1904177_1904453_+|hypothetical-protein
MENKFVPGILIGAVIGGAISLADKSTRQALVQSVKDAKNGNRTRKPSKVSKIKDEVLYWKDVVEEIRRNNPELERSLKDAKETFVNRKNQR
>NC_022226.1|WP_000228666.1|1903706_1904171_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFDYIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG
>NC_022226.1|WP_000180460.1|1903359_1903560_-|DUF1128-family-protein
MTNEEKVLAIREKLNIVNQGLLDPEKYKNANEEELTDIYDFVQSRERLSPSEVTAIADALGQLRHD
>NC_022226.1|WP_001789555.1|1902100_1903357_-|aminopeptidase
MGILTNYKEKLQQYAELLVKVGMNVQPKQPVFIRSSVETLELTHLIVEEAYHCGASDVRVVYSDPTLKRLKFENESVEHFANHELKSYDVEARMDYVKRGAANLALISEDPDLMDGIDSQKLQAFQQQNARAFKGYMESVQKNQFPWVVAAFPSKAWAKRVYPELSVEEAYIKFIDEVFDIVRIDGNDPVENWRQHIANLSVYAQKLQQKNYHALHYVSEGTDLTVGLAKNHIWEDATSYVNGKEQAFIANIPTEEVFTAPDRNRVDGYVTNKLPLSYNGTIIDQFKLMFKDGEIIDFSAEKGEAVLKDLINTDEGSRRLGEVALVPDDSPISNRNTIFYNTLFDENAACHLAIGSAYAFNIQGGTEMTVEEKIASGLNDSNVHVDFMIGSSDLTIYGIFEDGSKELVFENGNWASTF
>NC_022226.1|WP_000999714.1|1910323_1911310_+|aromatic-acid-exporter-family-protein
MNDQWYKHLIGARTIKTGIAIFLTAVFCMALDLTPIYAILTAVVTIEPTAKASLIKGYRRLPATVIGAGFAVLFTYLFGDQSPFTYALSATFTILFCTKLKLQVGTNVAVLTSLAMIPGIHDAYIFNFLSRTLTAIIGLVTSGLINFMVFPPKYYGQVEEKLSKTDALMYKLFYNRCQELILSRLQSDKSEKAYKNIFNLNNQVETLISYQRDELSYHKKKECDWKLLNQLTKRAYTNRLFITHLSNIIYLPKNTRVNFSGDEKMALLKISSSIKDIFYDGSFKREDDSVETLRSTIKALEISGENQIKSHLLYEVLMIYRLLDSRYA
>NC_022226.1|WP_025173836.1|1911740_1912154_-|hypothetical-protein
MKPTKVILRDASYLHSKTSITFILKDVVIEEDNKIYYFDTSATFEDQEVKFEFALFDSDMDNLKHMDYDNPVTEIYFIEPDLHFTIIDFNQELLCIYIDFDSGLRHSNMATESGISLRINVAKSDFTKFINELASLY
>NC_022226.1|WP_001790257.1|1912182_1912293_-|hypothetical-protein
MDGNNQIDVCFFVLVNNYYTMSIYPRIINSNGDYAT
>NC_022226.1|WP_000544965.1|1912378_1913110_-|type-1-glutamine-amidotransferase
MHELTIYHFMSDKLNLYSDIGNIIALRQRAKKRNIKVNVVEINETEGITFDECDIFFIGGGSDREQALATKELSKIKTPLKEAIEDGMPGLTICGGYQFLGKKYITPDGTELEGLGILDFYTESKTNRLTGDIIIESDTFGTIVGFENHGGRTFHDFGTLGHVTFGYGNNDEDKKEGIHYKNLLGTYLHGPILPKNYEITDYLLEKACERKGIPFEPKEIDNEAEIQAKQVLIDRANRQKKSR
>NC_022226.1|WP_001250329.1|1913111_1914425_-|lipid-II-isoglutaminyl-synthase-subunit-MurT
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDILRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNADDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISSFDVAPFLHLNINDEKYDMKIAGDFNAYNALAAYSVLRELGLNEQTIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
>NC_022226.1|WP_000949467.1|1914716_1915217_+|H-type-ferritin-FtnA
MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEESMFETHINYLTRIGDDSNALYLYEKELGARTFDEE
>NC_022226.1|WP_001790679.1|1915298_1915391_-|hypothetical-protein
MTKNTIISLENEKTQINDSENESSDLRKAK
>NC_022226.1|WP_000613738.1|1915606_1916161_+|3'-5'-exonuclease
MIQDAFVALDFETANGKRTSICSVGMVKVIDSQITETFHTLVNPQDYFSQQNIKVHGIQPEDVENAPTFDYVFPYMMQFIADLPVVAHNAAFDMNVLHQSIQNIGLPTPNLTYFCSYQLAKRTVDSYRYGLKHMMEFYQLDFHGHHDALNDAKACAMITFRLLKNYENLTYVTNIYGKNLKDKG
>NC_022226.1|WP_000140181.1|1916227_1917298_-|DNA-polymerase-IV
MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVYSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEKTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYQNVHDILMTLDIGEFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI
>NC_022226.1|WP_000548781.1|1917544_1918075_-|DUF3267-domain-containing-protein
MHKIDLTTNNFQMRRFIILQLVIALFVILFTYKWALGVTAVVDQNIIINLVYGFAGFIILLILHELIHRALFLLFKKDSKPMFNIKKDRILFQTADACFNKWQFSIIMLSPLILLSTGLLILIKVFGYSSLIFMFSMHTAYCFIDILLVALTISSSFKYVQQDEDSIYLYHQKPTQ

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Crispr_ID: NC_022226_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022226_7

2153694-2153774

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_022226_7

>merge|NC_022226|7|2153694-2153774|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTCAACTTTAGTTGTTAGGGGCTTCT

>NC_022226|7|7|2153694-2153774|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTT	ATGCATGCGCTTAGCGCAGGCGCTCCTACTTTT
CAACTTTAGTTGTTAGGGGCTTCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022226.1\|WP_000808817.1\|2148565_2148796_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000908189.1\|2156634_2157417_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NC_022226.1\|WP_000160304.1\|2144176_2144887_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_022226.1\|WP_000019743.1\|2151339_2152320_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NC_022226.1\|WP_000334465.1\|2157648_2159454_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NC_022226.1\|WP_000370928.1\|2155709_2156567_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NC_022226.1\|WP_001127964.1\|2148826_2149765_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NC_022226.1\|WP_000123402.1\|2146520_2147894_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NC_022226.1\|WP_000083807.1\|2160134_2161673_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NC_022226.1\|WP_000648720.1\|2164285_2165392_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NC_022226.1\|WP_000070866.1\|2145007_2145451_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NC_022226.1\|WP_001802298.1\|2154109_2154214_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_029160279.1\|2161707_2163840_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_022226.1\|WP_020978304.1\|2165710_2173165_-\|DUF1542-domain-containing-protein	unknown	unknown	gnl\|CDD\|275089
NC_022226.1\|WP_000003755.1\|2151017_2151338_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_022226.1\|WP_001024095.1\|2150200_2150866_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NC_022226.1\|WP_001292149.1\|2163851_2164286_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NC_022226.1\|WP_001792784.1\|2154893_2155052_+\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000495681.1\|2152585_2153677_+\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_001123301.1\|2145650_2146064_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556

Protein	Function_ID	Function_description	E-value
NC_022226.1\|WP_000334465.1\|2157648_2159454_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NC_022226.1\|WP_000908189.1\|2156634_2157417_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	3.34326e-106
NC_022226.1\|WP_000160304.1\|2144176_2144887_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NC_022226.1\|WP_000123402.1\|2146520_2147894_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.86989e-06
NC_022226.1\|WP_000083807.1\|2160134_2161673_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NC_022226.1\|WP_001127964.1\|2148826_2149765_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	3.25063e-129
NC_022226.1\|WP_000019743.1\|2151339_2152320_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.20197e-108
NC_022226.1\|WP_000648720.1\|2164285_2165392_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NC_022226.1\|WP_000070866.1\|2145007_2145451_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.22744e-67
NC_022226.1\|WP_029160279.1\|2161707_2163840_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	4.68454e-68
NC_022226.1\|WP_020978304.1\|2165710_2173165_-\|DUF1542-domain-containing-protein	gnl\|CDD\|275089	TIGR04263, cell_wall_surface_anchor_family_protein, SasC/Mrp/FmtB intercellular aggregation domain. This domain, about 375 amino acids long on average, occurs only in Staphylococcus and Streptococcus. It occurs as a non-repetitive N-terminal domain of LPXTG-anchored surface proteins, including SasC, Mrp, and FmtB. This region in SasC was shown to be involved in cell aggregation and biofilm formation, which may explain the methicillin resistance seen for Mrp and FmtB.	2.13224e-108
NC_022226.1\|WP_000003755.1\|2151017_2151338_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	2.83702e-17
NC_022226.1\|WP_001024095.1\|2150200_2150866_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.27122e-47
NC_022226.1\|WP_001292149.1\|2163851_2164286_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
NC_022226.1\|WP_000370928.1\|2155709_2156567_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.99434e-58
NC_022226.1\|WP_001123301.1\|2145650_2146064_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	1.45785e-45

>NC_022226.1|WP_000495681.1|2152585_2153677_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKETTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NC_022226.1|WP_000019743.1|2151339_2152320_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHAH
>NC_022226.1|WP_000003755.1|2151017_2151338_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEIHTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NC_022226.1|WP_001024095.1|2150200_2150866_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFDGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGEQDIKDALTQFEIEKD
>NC_022226.1|WP_001127964.1|2148826_2149765_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQRGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NC_022226.1|WP_000808817.1|2148565_2148796_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NC_022226.1|WP_000123402.1|2146520_2147894_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NC_022226.1|WP_001123301.1|2145650_2146064_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIKLITALPNRTKLLGVGLWFVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NC_022226.1|WP_000070866.1|2145007_2145451_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLENAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NC_022226.1|WP_000160304.1|2144176_2144887_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NC_022226.1|WP_001802298.1|2154109_2154214_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NC_022226.1|WP_001792784.1|2154893_2155052_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NC_022226.1|WP_000370928.1|2155709_2156567_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINQLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQITNLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITTFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQDETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NC_022226.1|WP_000908189.1|2156634_2157417_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINGGDKWILYGLNGAGKTTLLNILNAYEPATTGDVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEIRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSESYPTLAMIYVTHFIEEITSNFTKILLLKDGKSVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NC_022226.1|WP_000334465.1|2157648_2159454_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>NC_022226.1|WP_000083807.1|2160134_2161673_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NC_022226.1|WP_029160279.1|2161707_2163840_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGTDSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVNKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIEIYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDIDGNTSFENEQTSYLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDAINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMVLITVLEEPLILPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NC_022226.1|WP_001292149.1|2163851_2164286_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>NC_022226.1|WP_000648720.1|2164285_2165392_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVKDSSIEAGLRRVLAETSQYITIEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS
>NC_022226.1|WP_020978304.1|2165710_2173165_-|DUF1542-domain-containing-protein
MNLFRQQKFSIRKFNVGIFSALIATVTFISTNPTTASAAEQNQPAQNQPAQPADANTQPNANAGAQANPTAQPAAPANQGQPAVQPANQGGQANPAGGAAQPNTQPAGQGNQADPNNAAQAQPGNQATPANQAGQGNNQATPNNNATPANQTQPANAPAAAQPAAQPAAPVAANAQTQDPNASNTGEGSINTTLTFDDPAISTDENRQDPTVTVTDKVNGYSLINNGKIGFVNSELRRSDMFDKNNPQNYQAKGNVAALGRVNANDSTDHGNFNGISKTVNVKPDSELIINFTTMQTNSKQGATNLVIKDAKKNTELATVNVAKTGTAHLFKVPTDADRLDLQFIPDNTAVADASRITTNKDGYKYYSFIDNVGLFSGSHLYVKNRDLAPKATNNKEYTINTEIGNNGNFGASLKADQFKYEVTLPQGVTYVNDSLTTTFPNGNEDSTVLKNMTVNYDQNANKVTFTSQGVTTARGTHTKEVLFPDKSLKLSYKVNVANIDTPKNIDFNEKLTYRTASDVVINNTQPEITLTADPFSVAVEMNKDALQQQVNSQVDNSHYTTASIAEYNKLKQQADTILNEDANHVETANRASQADIDGLVTKLQAALIDNQAAIAELDAKAQEKVTAAQQSKKVTQDEVAALVTKINNDKNNAIAEINKQTTSQGVTTEKDNGIAVLEQDVITPTVKPQAKQDIIQAVTTRKQQIKKSNASLQDEKDVANDKIGKIETKAIKDIDAATTNAQVEAIKTKAINDINQTTPATTAKAAALEEFDEVVQAQIDQAPLNPDTTNEEVAEAIERINAAKVSGVKAIEATTTAQDLERVKNEEISKIENITDSTQTKMDAYNEVKQAATARKAQNATVSNATNEEVAEADAAVDAAQKQGLHDIQVVKSKQEVADTKSKVIDKINAIQTQAKVKPAADTEVENAYNTRKQEIQNSNASTTEEKQAAYTELDTKKQEARTNLDAANTNSDVTTAKDNGIAAINQVQAATTKKSDAKAEIAQKASERKTAIEAMNDSTTEEQQAAKDKVDQAVVTANADIDNATANTDVDNAKTTNEATIAAITPDANVKPQAKQAIADKVQAQETAIDANNGSTTEEKTAAKQQAQTEKTTADAAIDAAHTNAEVEAAKNAEIAKIEAIQPATTTKDNAKEAIATKANERKTAIAQTQDSTAEEIAAANADVDNAVTQANSNIEAANSQNDVDQAKTTGETSIDQVTPTVNKKATARNEITTILNNKLQEIQATPDATDEEKQAADAEANTENGKANQAISAATTNAQVDEAKANAEAAINAVTPKVVKKQAAKDEIDQLQATQTNVINNDQNATTEEKEAAIQQLATAVTDAKNNITAATDDNGVDQAKDAGKNSIQSTQPATAVKSNAKNDVDQAVTTQNQAIDNTTGATTEEKNAAKDLVLKAKEKAYQDILNAQTTNDVTQIKDQAVADIQGITADTTIKDVAKDELATKANEQKALIAQTADATTEEKEQANQQVDAQLTQGNQNIENAQSIDDVNTAKENAIQAIDPIQASTDVKTNARAELLTEMQNKITEILSDNTTTNEEKGKDIEPVRATYEEGLNNINTANTTGDVTTAKDTAVQKVQQLHANPVKKPAGKTALDQAAADRKTQIEQTPNASQQEINDAKQEVDAALNQAKTNVDQSSTNEYVDNAVKEGKAKINAVKTFSEYKKDALAKIADAYNAKVNEADNSNASTSSEIAEAKQKLAELKQTADQNVNQATSKDDIEVQIHNDLDNINDYTIPTGKKETATTDLYAYADQKKNNISADTNATQDEKQQAIKQVDQNVQTALESINNGVDNGDVDDALTQGKAAIDAIQVDATVKPKANQAIEVKAEDTKESIDQSDQLTAEEKTEALAMIKQITDQAKQGITDATTTAEVEKAKAQGLEAFDNIQIDSTEKQKAIEELETALDQIEAGVNVDADATTEEKEAFTNALEDILSKATEDISDQTTNAEIATVKNSALEQLKAQRINPEVKKNALEAIREVVNKQIEIIKNADADASAKEIARTDLGRYFDRFADKLDKTQTNAEVAELQNVTIPAIEAIVPQNDPDANDTNNGIDNNDATANSNANATPENTGQPNVSETTDNGKADASPTTPNNSDAATGETTATSATDDANDKPQANNNSSVDASTNSPTMDNDVTSKPEVESTNNGTTDKPVTETDNATPAESTTNNNSTTTATNENAPTGSTATAPTTASTEAASSADSKDNASVNDSKQNAEVNNSAESQSTNGKVAQPKSENKAKAEKDGRDSTNQSMVESTTETLPSADITEPNVPSNTSKDKEESTTNQTDAGQLKSETNVASNEADKSPSKADTEVSNKPSTSASSEAKDKMTSTNVSQKDDTATADTNDTQTSVGPVANNKAKDMQTNDMKASLATVSNGSNSANQDMLNVTNTDDHQAKTKSAQQGKVNKPKQQAKTLPDTGMSHNDDLPYAELALGAGMAFLIRRFTKKDQQTEE

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Crispr_ID: NC_022226_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022226_8

2419689-2419786

Orphan

Consensus_repeat	Method
TTTCTGCGAATTTTATGAGCTAGAAAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022226_8

>merge|NC_022226|8|2419689-2419786|CRISPRCasFinder
TTTCTGCGAATTTTATGAGCTAGAAAGGCTTATGCATTAGTAGCGAAGCTATCTAATGCGTTCCTTTATTTTCTGCGAATTTTATGAGCTAGAAAGGC

>NC_022226|8|8|2419689-2419786|CRISPRCasFinder
TTTCTGCGAATTTTATGAGCTAGAAAGGC	TTATGCATTAGTAGCGAAGCTATCTAATGCGTTCCTTTAT
TTTCTGCGAATTTTATGAGCTAGAAAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022226.1\|WP_000615461.1\|2413470_2414202_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_022226.1\|WP_001046645.1\|2427894_2428902_-\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NC_022226.1\|WP_001125208.1\|2417669_2418356_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518
NC_022226.1\|WP_000792552.1\|2420301_2421612_+\|B-domain-containing-protein	unknown	unknown	gnl\|CDD\|288473
NC_022226.1\|WP_000286879.1\|2426098_2426791_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342
NC_022226.1\|WP_000200946.1\|2425620_2426088_-\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|377623
NC_022226.1\|WP_001110069.1\|2428903_2430262_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NC_022226.1\|WP_000819843.1\|2411506_2411869_-\|DUF4467-domain-containing-protein	unknown	unknown	gnl\|CDD\|291399
NC_022226.1\|WP_001789935.1\|2420102_2420207_-\|hypothetical-protein	unknown	unknown	unknown
NC_022226.1\|WP_000762708.1\|2417411_2417516_+\|putative-metal-homeostasis-protein	unknown	unknown	unknown
NC_022226.1\|WP_000038960.1\|2415798_2417238_-\|multidrug-efflux-MFS-transporter-MdeA	unknown	unknown	gnl\|CDD\|129794
NC_022226.1\|WP_000971546.1\|2426801_2427917_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
NC_022226.1\|WP_000783428.1\|2424591_2425569_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	unknown	unknown	gnl\|CDD\|273388
NC_022226.1\|WP_000825921.1\|2414898_2415678_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270429
NC_022226.1\|WP_000162803.1\|2410888_2411488_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565
NC_022226.1\|WP_000916704.1\|2423642_2424590_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	unknown	unknown	gnl\|CDD\|369625
NC_022226.1\|WP_000594519.1\|2422146_2423076_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	unknown	unknown	gnl\|CDD\|369625
NC_022226.1\|WP_001012228.1\|2412123_2413374_+\|FemA/FemB-family-glycyltransferase-FmhA	unknown	unknown	gnl\|CDD\|367067
NC_022226.1\|WP_000479576.1\|2414198_2414918_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_022226.1\|WP_000019127.1\|2418682_2419549_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131

Protein	Function_ID	Function_description	E-value
NC_022226.1\|WP_000615461.1\|2413470_2414202_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	3.20826e-144
NC_022226.1\|WP_001046645.1\|2427894_2428902_-\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NC_022226.1\|WP_001125208.1\|2417669_2418356_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167
NC_022226.1\|WP_000792552.1\|2420301_2421612_+\|B-domain-containing-protein	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	1.70632e-25
NC_022226.1\|WP_000286879.1\|2426098_2426791_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	2.9803e-130
NC_022226.1\|WP_000200946.1\|2425620_2426088_-\|QueT-transporter-family-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.00158559
NC_022226.1\|WP_001110069.1\|2428903_2430262_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NC_022226.1\|WP_000819843.1\|2411506_2411869_-\|DUF4467-domain-containing-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	3.11961e-31
NC_022226.1\|WP_000162803.1\|2410888_2411488_-\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	2.24775e-30
NC_022226.1\|WP_000038960.1\|2415798_2417238_-\|multidrug-efflux-MFS-transporter-MdeA	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.41176e-92
NC_022226.1\|WP_000971546.1\|2426801_2427917_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	1.99808e-138
NC_022226.1\|WP_000783428.1\|2424591_2425569_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	5.50766e-128
NC_022226.1\|WP_000825921.1\|2414898_2415678_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.11829e-100
NC_022226.1\|WP_000916704.1\|2423642_2424590_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	7.97441e-93
NC_022226.1\|WP_000594519.1\|2422146_2423076_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.31899e-97
NC_022226.1\|WP_001012228.1\|2412123_2413374_+\|FemA/FemB-family-glycyltransferase-FmhA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0
NC_022226.1\|WP_000479576.1\|2414198_2414918_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.98247e-78
NC_022226.1\|WP_000019127.1\|2418682_2419549_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.54055e-90

>NC_022226.1|WP_000019127.1|2418682_2419549_-|cation-transporter
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNAPRLFKEDDVVPNAITIIVSLISGLVMLIVFAVNQRLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>NC_022226.1|WP_001125208.1|2417669_2418356_-|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>NC_022226.1|WP_000762708.1|2417411_2417516_+|putative-metal-homeostasis-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>NC_022226.1|WP_000038960.1|2415798_2417238_-|multidrug-efflux-MFS-transporter-MdeA
MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGVVLVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFSPTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
>NC_022226.1|WP_000825921.1|2414898_2415678_-|transporter-substrate-binding-domain-containing-protein
MKRLLFVMIAFVFILAACGNNSSKDKEANKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKEEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSRSAFAFSKKADDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>NC_022226.1|WP_000479576.1|2414198_2414918_-|amino-acid-ABC-transporter-permease
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>NC_022226.1|WP_000615461.1|2413470_2414202_-|amino-acid-ABC-transporter-ATP-binding-protein
MIQLNNIHKSFNDVEVIKGIDLSVEQGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVYVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKDEARGKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAKEVSNNIVFIHEGMIGEQGAPEEMFNRPKTEELRRFLNVINEE
>NC_022226.1|WP_001012228.1|2412123_2413374_+|FemA/FemB-family-glycyltransferase-FmhA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDTLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEALKESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPMFYKIQQYLNHKRR
>NC_022226.1|WP_000819843.1|2411506_2411869_-|DUF4467-domain-containing-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYDFSDKRVSYKQDFDSRRYYQQHDADYHEENMTN
>NC_022226.1|WP_000162803.1|2410888_2411488_-|DsbA-family-protein
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPFCKELDEKVMPKLRKNYIDNHKVEYQFVNLAFLGKDSIVGSRASHAVLMYAPKSFLDFQKQLFAAQQDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKDNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>NC_022226.1|WP_001789935.1|2420102_2420207_-|hypothetical-protein
MLTNRLTSVNYVKKRLIQNIQRILSKEVLYGEMQ
>NC_022226.1|WP_000792552.1|2420301_2421612_+|B-domain-containing-protein
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDKSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAITKLQKNDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYTDKYFKYKGTIDKTVLSVFGNGYKSYIQPLKVEDQKNYVSKSYAQVRNYVTETLNTGKVLYAFYQNPKVVKAAITTAETASSIKNTLSNLLSFWK
>NC_022226.1|WP_000594519.1|2422146_2423076_+|bi-component-gamma-hemolysin-HlgAB-subunit-A
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>NC_022226.1|WP_000916704.1|2423642_2424590_+|bi-component-gamma-hemolysin-HlgCB-subunit-C
MLKNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN
>NC_022226.1|WP_000783428.1|2424591_2425569_+|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B
MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>NC_022226.1|WP_000200946.1|2425620_2426088_-|QueT-transporter-family-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSLLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTMRKRMAVLLR
>NC_022226.1|WP_000286879.1|2426098_2426791_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDNRIDLNHYISFLESTPKQVVYETV
>NC_022226.1|WP_000971546.1|2426801_2427917_-|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIQKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDIDRLFEILHQED
>NC_022226.1|WP_001046645.1|2427894_2428902_-|biotin-synthase-BioB
MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYDTCENKENKNDVSRAN
>NC_022226.1|WP_001110069.1|2428903_2430262_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGSSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGAVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMTAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYNAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRKLLSHIESTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRKCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	156467-156491	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	360087-360111	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	360142-360166	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	627086-627110	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	797514-797538	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	797572-797596	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	797630-797654	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	797688-797712	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	1009912-1009936	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	1320058-1320082	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	1408647-1408671	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	1585528-1585552	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	1761567-1761591	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	1911413-1911437	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	2258745-2258769	1	0.96
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	2597865-2597889	1	0.96
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	360099-360130	1	0.969
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	360154-360185	1	0.969
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	1761579-1761610	1	0.969
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_022226.1	359982-360012	1	0.968
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_022226.1	627153-627183	1	0.968
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_022226.1	1009839-1009869	1	0.968
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_022226.1	1110299-1110329	1	0.968
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_022226.1	1320125-1320155	1	0.968
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_022226.1	1585455-1585485	1	0.968
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_022226.1	2258789-2258819	1	0.968
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_022226.1	2547446-2547476	1	0.968
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	804828-804852	2	0.92
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	1324548-1324572	2	0.92
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	NC_022226.1	2269665-2269689	2	0.92
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	156479-156510	2	0.938
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	627098-627129	2	0.938
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	797553-797584	2	0.938
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	797611-797642	2	0.938
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	797669-797700	2	0.938
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	1920743-1920774	2	0.938
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	2269646-2269677	2	0.938
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	NC_022226.1	2597877-2597908	2	0.938
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_022226.1	797441-797471	2	0.935
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_022226.1	2269706-2269736	2	0.935

1. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 156467-156491, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

2. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 360087-360111, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctatgttg	Protospacer
******************* *****

3. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 360142-360166, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctatgttg	Protospacer
******************* *****

4. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 627086-627110, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

5. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 797514-797538, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

6. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 797572-797596, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

7. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 797630-797654, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

8. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 797688-797712, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

9. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 1009912-1009936, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

10. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 1320058-1320082, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

11. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 1408647-1408671, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

12. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 1585528-1585552, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

13. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 1761567-1761591, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

14. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 1911413-1911437, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

15. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 2258745-2258769, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

16. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 2597865-2597889, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

17. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 360099-360130, mismatch: 1, identity: 0.969

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgcttgtagaatttcttttcgaaa	Protospacer
**********.*********************

18. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 360154-360185, mismatch: 1, identity: 0.969

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgcttgtagaatttcttttcgaaa	Protospacer
**********.*********************

19. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 1761579-1761610, mismatch: 1, identity: 0.969

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgtctgtagaatttcttttcgaaa	Protospacer
***********.********************

20. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to position: 359982-360012, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

21. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to position: 627153-627183, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

22. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to position: 1009839-1009869, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

23. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to position: 1110299-1110329, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

24. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to position: 1320125-1320155, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

25. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to position: 1585455-1585485, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

26. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to position: 2258789-2258819, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

27. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to position: 2547446-2547476, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

28. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 804828-804852, mismatch: 2, identity: 0.92

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcatttcgaaattctctgtgttg	Protospacer
**** ************** *****

29. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 1324548-1324572, mismatch: 2, identity: 0.92

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttatcgaaattctctgtgttg	Protospacer
****** ************ *****

30. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to position: 2269665-2269689, mismatch: 2, identity: 0.92

tttcttttcgaaattctctttgttg	CRISPR spacer
tttctttttgaaattctctatgttg	Protospacer
********.********** *****

31. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 156479-156510, mismatch: 2, identity: 0.938

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgcctgtagaatttcttttcgaaa	Protospacer
**********..********************

32. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 627098-627129, mismatch: 2, identity: 0.938

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgcctgtagaatttcttttcgaaa	Protospacer
**********..********************

33. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 797553-797584, mismatch: 2, identity: 0.938

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgcctgtagaatttcttttcgaaa	Protospacer
**********..********************

34. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 797611-797642, mismatch: 2, identity: 0.938

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgcctgtagaatttcttttcgaaa	Protospacer
**********..********************

35. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 797669-797700, mismatch: 2, identity: 0.938

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgcctgtagaatttcttttcgaaa	Protospacer
**********..********************

36. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 1920743-1920774, mismatch: 2, identity: 0.938

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgtctgtagaatttcctttcgaaa	Protospacer
***********.***********.********

37. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 2269646-2269677, mismatch: 2, identity: 0.938

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgtctgtagaatttctttttgaaa	Protospacer
***********.***************.****

38. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to position: 2597877-2597908, mismatch: 2, identity: 0.938

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
acttgcattgcctgtagaatttcttttcgaaa	Protospacer
**********..********************

39. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to position: 797441-797471, mismatch: 2, identity: 0.935

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtaagct	Protospacer
********.***************** ****

40. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to position: 2269706-2269736, mismatch: 2, identity: 0.935

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtatgctgacttttcgtcagct	Protospacer
********.*** ******************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022226_1	1.1\|260141\|25\|NC_022226\|CRISPRCasFinder	260141-260165	25	LC371242	Escherichia phage EcS1 DNA, complete sequence	15447-15471	2	0.92
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	NC_021536	Synechococcus phage S-IOM18 genomic sequence	159749-159779	8	0.742
NC_022226_6	6.1\|1910000\|31\|NC_022226\|CRISPRCasFinder	1910000-1910030	31	LN846932	Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome	10622-10652	8	0.742
NC_022226_3	3.1\|792002\|32\|NC_022226\|CRISPRCasFinder	792002-792033	32	MN693281	Marine virus AFVG_25M371, complete genome	6448-6479	9	0.719

1. spacer 1.1|260141|25|NC_022226|CRISPRCasFinder matches to LC371242 (Escherichia phage EcS1 DNA, complete sequence) position: , mismatch: 2, identity: 0.92

tttcttttcgaaattctctttgttg	CRISPR spacer
tttctttacgaaattctttttgttg	Protospacer
******* *********.*******

2. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to NC_021536 (Synechococcus phage S-IOM18 genomic sequence) position: , mismatch: 8, identity: 0.742

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
aattttatcgtaaggtgagttttcgtcaagc	Protospacer
 *. ********** *** *********. .

3. spacer 6.1|1910000|31|NC_022226|CRISPRCasFinder matches to LN846932 (Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome) position: , mismatch: 8, identity: 0.742

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
taatttatcgtaatctgatttttcgtcttca	Protospacer
.*  ********* ****.********  *

4. spacer 3.1|792002|32|NC_022226|CRISPRCasFinder matches to MN693281 (Marine virus AFVG_25M371, complete genome) position: , mismatch: 9, identity: 0.719

acttgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
ttttgcattgtttgtaggatttcttctaagtg	Protospacer
 .***************.*******.* .. .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

729481 : 737301

Hokovirus(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244415.1\|729481_730537_-	two-component system sensor histidine kinase SaeS	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|730536_731223_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037807.1\|731197_731671_-	DoxX family protein	NA	NA	NA	NA
WP_001093557.1\|732012_732453_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637687.1\|732732_733317_-	hypothetical protein	NA	NA	NA	NA
WP_001062972.1\|733415_734129_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941340.1\|734132_734552_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446724.1\|734553_735222_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604514.1\|735572_736166_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.4e-38	42.9
WP_001217801.1\|736149_737301_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	7.8e-23	35.7

DBSCAN-SWA_2

749272 : 763626

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663030.1\|749272_750331_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	7.9e-22	26.7
WP_000197271.1\|750625_751168_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429008.1\|751791_752709_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	2.8e-07	22.4
WP_031760357.1\|752798_752900_+	hypothetical protein	NA	NA	NA	NA
WP_000193751.1\|752977_754483_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930012.1\|754823_755324_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.9e-52	71.5
WP_001068487.1\|755343_756210_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|757023_757422_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855505.1\|757384_759490_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|759607_760579_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000499195.1\|760759_760915_+	hypothetical protein	NA	NA	NA	NA
WP_000876318.1\|760953_761925_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.3e-139	78.9
WP_001245577.1\|761911_762868_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000616840.1\|762864_763626_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	6.5e-18	31.6

DBSCAN-SWA_3

1011265 : 1019738

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000861572.1\|1011265_1011748_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7
WP_001010412.1\|1011734_1012859_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174053.1\|1012862_1013567_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	42.1
WP_000848350.1\|1013566_1013830_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666794.1\|1013831_1014503_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032727.1\|1014495_1016685_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.0e-140	39.7
WP_031871549.1\|1016663_1018148_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	4.2e-45	31.5
WP_000030811.1\|1018140_1019169_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	3.4e-62	41.7
WP_000238670.1\|1019171_1019738_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.6e-29	40.1

DBSCAN-SWA_4

1557000 : 1565330

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1557000_1557786_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924220.1\|1557911_1558802_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	3.4e-26	36.0
WP_001062177.1\|1558811_1560158_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	2.4e-55	34.0
WP_000683933.1\|1560271_1561372_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	5.2e-08	29.6
WP_000624571.1\|1561374_1562052_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283055.1\|1562182_1563289_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217246.1\|1563512_1565330_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.6e-54	36.0

DBSCAN-SWA_5

1633109 : 1642149

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1633109_1633628_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000595005.1\|1633649_1635920_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	2.4e-63	29.3
WP_000749795.1\|1636122_1638402_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1638676_1638937_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112049.1\|1638955_1640095_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	1.6e-84	44.7
WP_001019178.1\|1640117_1641143_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005767.1\|1641144_1642149_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_6

1782452 : 1834360

Staphylococcus_phage(95.0%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001196354.1\|1782452_1783454_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
WP_001008551.1\|1783575_1784040_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
WP_001159022.1\|1784052_1785234_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	6.6e-227	99.7
WP_000493892.1\|1785244_1785877_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.7e-112	99.5
WP_000077358.1\|1785883_1786927_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	5.3e-196	98.8
WP_001261668.1\|1787407_1788910_-	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	1.9e-29	98.6
WP_000221177.1\|1789432_1789747_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	9.8e-53	98.1
WP_000989121.1\|1789746_1791039_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	5.0e-228	99.5
WP_001032833.1\|1791125_1791980_-	glucosaminidase domain-containing protein	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1792255_1792480_-	hypothetical protein	NA	NA	NA	NA
WP_000671052.1\|1792678_1793149_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	1.0e-82	99.4
WP_001153742.1\|1793261_1793705_+	competence protein ComK	NA	NA	NA	NA
WP_020978228.1\|1793691_1794135_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	7.1e-57	98.0
WP_001168907.1\|1794430_1795066_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_001096494.1\|1795505_1796219_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091445.1\|1796478_1796781_+	hypothetical protein	NA	NA	NA	NA
WP_001200542.1\|1797036_1797402_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
WP_000623477.1\|1797398_1797752_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	1.0e-21	94.9
WP_000453317.1\|1799749_1800583_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	3.5e-158	99.6
WP_000366163.1\|1800794_1801703_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.4e-138	100.0
WP_000933822.1\|1801827_1803021_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000109906.1\|1803392_1804985_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	100.0
WP_073392436.1\|1805237_1805984_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	1.3e-143	99.6
WP_000672015.1\|1805988_1806462_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	5.5e-84	99.4
WP_000718107.1\|1806527_1806785_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778537.1\|1806781_1807783_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	5.1e-188	98.8
WP_000348363.1\|1807787_1809266_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.5e-284	98.2
WP_072460539.1\|1809424_1809880_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	1.0e-79	99.3
WP_001789021.1\|1810182_1810833_+	excalibur calcium-binding domain-containing protein	A0A2H4PQM8	Staphylococcus_phage	5.2e-56	98.6
WP_000070648.1\|1810913_1811909_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	9.6e-70	94.4
WP_000669021.1\|1811982_1812609_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	1.3e-88	91.3
WP_000627547.1\|1812649_1812991_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	3.9e-55	95.6
WP_000864139.1\|1813860_1814418_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	3.1e-78	97.5
WP_000375476.1\|1814788_1814965_-	hypothetical protein	NA	NA	NA	NA
WP_000070811.1\|1814975_1815359_-	hypothetical protein	NA	NA	NA	NA
WP_000747802.1\|1816043_1816490_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_001801861.1\|1816940_1817036_+	type I toxin-antitoxin system Fst family toxin PepA1	NA	NA	NA	NA
WP_001791232.1\|1817158_1817260_+	hypothetical protein	NA	NA	NA	NA
WP_000695818.1\|1817607_1817982_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_001566695.1\|1818003_1818351_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_020978241.1\|1818587_1819004_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000072558.1\|1819650_1820769_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	7.6e-39	35.1
WP_044027547.1\|1820761_1822318_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	6.8e-288	99.2
WP_001791797.1\|1822481_1822616_-	hypothetical protein	NA	NA	NA	NA
WP_001038706.1\|1822680_1823400_-\|protease	serine protease SplD	A0A2H4PQP9	Staphylococcus_phage	5.1e-129	99.2
WP_001038867.1\|1823520_1824240_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	1.2e-130	99.2
WP_001039444.1\|1824297_1825020_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	6.4e-132	100.0
WP_001039432.1\|1825144_1825852_-\|protease	serine protease SplA	A0A2H4PQN3	Staphylococcus_phage	1.6e-127	97.9
WP_001092759.1\|1826815_1827394_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	1.9e-49	59.6
WP_000550252.1\|1828341_1828815_+	hypothetical protein	NA	NA	NA	NA
WP_000543854.1\|1828819_1829611_+	DUF1828 domain-containing protein	NA	NA	NA	NA
WP_000782463.1\|1829981_1830965_-	bi-component leukocidin LukED subunit D	A0A2H4PQH7	Staphylococcus_phage	1.8e-185	99.4
WP_000473596.1\|1830966_1831902_-	bi-component leukocidin LukED subunit E	A0A2H4PQI5	Staphylococcus_phage	1.4e-174	100.0
WP_000209099.1\|1833265_1834054_+	DUF1828 domain-containing protein	A0A2H4PQI0	Staphylococcus_phage	1.3e-138	95.0
WP_001792814.1\|1834231_1834360_+\|transposase	IS3 family transposase	A0A2H4PQU1	Staphylococcus_phage	6.6e-08	66.7

DBSCAN-SWA_7

1921343 : 2021099

115

Staphylococcus_phage(87.01%)

integrase,protease,head,holin,terminase,portal,transposase,tRNA,capsid,tail

attL 1920737:1920761|attR 2032144:2032168

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1920737:1920761	attL	NA	NA	NA	NA
WP_000545370.1\|1921343_1922771_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_000027917.1\|1922783_1924241_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_000170162.1\|1924242_1924545_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_000957020.1\|1924912_1926451_+	sodium/proline symporter PutP	NA	NA	NA	NA
WP_031871503.1\|1926539_1927739_-	CamS family sex pheromone protein	NA	NA	NA	NA
WP_000992921.1\|1929757_1931950_-	DNA helicase PcrA	A7KV33	Bacillus_phage	1.0e-135	42.2
WP_000272071.1\|1931946_1932639_-	heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
WP_001165363.1\|1932810_1933113_-	hypothetical protein	NA	NA	NA	NA
WP_000572878.1\|1933221_1934517_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.6e-16	32.9
WP_000827764.1\|1935377_1936544_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_020978260.1\|1936574_1936901_+	staphostatin A	NA	NA	NA	NA
WP_000669864.1\|1937192_1937366_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011542.1\|1937346_1937949_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040866.1\|1938219_1939041_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	2.3e-69	52.7
WP_000284433.1\|1939033_1940503_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	3.5e-108	45.1
WP_000897635.1\|1940686_1941763_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177828.1\|1941782_1942577_+	prephenate dehydratase	NA	NA	NA	NA
WP_001802312.1\|1942648_1942756_+	hypothetical protein	NA	NA	NA	NA
WP_000323163.1\|1942766_1944329_-	SLC13 family permease	NA	NA	NA	NA
WP_000275706.1\|1944533_1945631_-	pectate lyase	U5PWM6	Bacillus_phage	2.5e-47	34.9
WP_000149686.1\|1946002_1946563_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|1946615_1947545_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_000637587.1\|1947737_1947911_-	hypothetical protein	NA	NA	NA	NA
WP_001021226.1\|1947962_1949342_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_000181322.1\|1949461_1950490_-	lactonase family protein	NA	NA	NA	NA
WP_001284658.1\|1950948_1951329_-	penicillinase repressor BlaI	NA	NA	NA	NA
WP_001096369.1\|1951318_1953076_-	beta-lactam sensor/signal transducer BlaR1	NA	NA	NA	NA
WP_000733621.1\|1953182_1954028_+	penicillin-hydrolyzing class A beta-lactamase BlaZ	A0A1B0VBP7	Salmonella_phage	3.4e-31	34.3
WP_020978265.1\|1954078_1955758_-\|transposase	IS1182 family transposase	A0ZS58	Staphylococcus_virus	5.5e-243	77.4
WP_000612780.1\|1957771_1958182_+	YolD-like family protein	U3PG23	Staphylococcus_phage	1.4e-30	54.2
WP_000514485.1\|1958210_1958576_-	hypothetical protein	NA	NA	NA	NA
WP_000026854.1\|1958584_1960648_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_000706211.1\|1960650_1961763_-\|integrase	tyrosine-type recombinase/integrase	P97010	Streptococcus_pyogenes_phage	8.7e-11	31.0
WP_000267034.1\|1962308_1962482_-	hypothetical protein	NA	NA	NA	NA
WP_001188043.1\|1962932_1963973_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000713072.1\|1964029_1964872_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001033971.1\|1964868_1965426_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966288.1\|1965485_1966010_-	membrane protein	NA	NA	NA	NA
WP_000182842.1\|1966130_1966694_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221651.1\|1966759_1967500_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_000763048.1\|1967499_1968372_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_000645733.1\|1968368_1969049_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991301.1\|1969049_1969946_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	1.1e-16	30.2
WP_000691584.1\|1969942_1970323_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681968.1\|1970581_1970758_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|1971000_1971099_-	hypothetical protein	NA	NA	NA	NA
WP_001068523.1\|1971298_1972585_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_001792928.1\|1973209_1974958_-	extracellular adherence protein Eap/Map	NA	NA	NA	NA
WP_000669789.1\|1975915_1976095_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	2.2e-25	100.0
WP_001791826.1\|1976405_1976666_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000727649.1\|1977742_1978192_+	chemotaxis-inhibiting protein CHIPS	A0A1P8L6A8	Staphylococcus_phage	1.1e-78	100.0
WP_020978269.1\|1979271_1979763_-	staphylokinase	A0A1X9H028	Staphylococcus_phage	3.6e-86	99.4
WP_000861038.1\|1979953_1980709_-	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
WP_000611512.1\|1980720_1980975_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_001791821.1\|1981026_1981134_+	hypothetical protein	NA	NA	NA	NA
WP_011447039.1\|1981186_1981363_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	2.2e-22	98.3
WP_000539688.1\|1981512_1981809_-	DUF2951 domain-containing protein	D2JLG2	Staphylococcus_phage	2.9e-46	100.0
WP_001040261.1\|1981866_1982154_-	hypothetical protein	D2JLG1	Staphylococcus_phage	1.3e-43	100.0
WP_001153681.1\|1982200_1982353_-	hypothetical protein	D2JLG0	Staphylococcus_phage	5.2e-20	100.0
WP_000582165.1\|1982342_1986128_-	hypothetical protein	A0A1X9H0H3	Staphylococcus_phage	0.0e+00	98.5
WP_000567408.1\|1986143_1987628_-\|tail	phage tail family protein	A0A2I6PDJ0	Staphylococcus_phage	1.2e-297	100.0
WP_001796452.1\|1987624_1992154_-\|tail	phage tail tape measure protein	A0A2I6PDK2	Staphylococcus_phage	0.0e+00	99.8
WP_001549167.1\|1992210_1992348_-	hypothetical protein	A0A2I6PDX7	Staphylococcus_phage	3.4e-18	100.0
WP_001096355.1\|1992398_1992749_-	hypothetical protein	G4KNQ8	Staphylococcus_phage	7.8e-59	100.0
WP_071621395.1\|1992798_1993023_-	Ig-like domain-containing protein	A0A075LYE8	Staphylococcus_phage	3.0e-32	100.0
WP_000268733.1\|1993064_1993709_-\|tail	phage tail protein	A0A1X9H0J2	Staphylococcus_phage	1.5e-119	100.0
WP_000565498.1\|1993709_1994117_-	hypothetical protein	G4KNQ6	Staphylococcus_phage	7.1e-72	100.0
WP_000114227.1\|1994113_1994518_-	HK97 gp10 family phage protein	G4KNQ5	Staphylococcus_phage	2.1e-68	99.3
WP_000755150.1\|1994514_1994877_-\|head,tail	head-tail adaptor protein	G4KNQ4	Staphylococcus_phage	4.4e-65	100.0
WP_000150936.1\|1994860_1995145_-\|head,tail	phage head-tail adapter protein	A0A2I6PDJ5	Staphylococcus_phage	2.3e-45	100.0
WP_000238237.1\|1995157_1995418_-	hypothetical protein	A0A0H3U504	Staphylococcus_phage	6.4e-42	100.0
WP_000154559.1\|1995437_1996583_-\|capsid	phage major capsid protein	G4KNQ3	Staphylococcus_phage	9.6e-215	100.0
WP_000642728.1\|1996606_1997344_-\|protease	Clp protease ClpP	G4KNQ2	Staphylococcus_phage	1.8e-129	100.0
WP_000025274.1\|1997327_1998515_-\|portal	phage portal protein	A0A2I6PDI1	Staphylococcus_phage	1.0e-219	100.0
WP_000625088.1\|1998530_2000192_-\|terminase	terminase large subunit	A0A2I6PDJ8	Staphylococcus_phage	0.0e+00	100.0
WP_000402904.1\|2000188_2000533_-	hypothetical protein	G4KNP9	Staphylococcus_phage	9.4e-57	100.0
WP_000988336.1\|2000663_2000963_-	HNH endonuclease	A0EWY8	Staphylococcus_phage	4.6e-52	100.0
WP_000590122.1\|2001194_2001611_-	hypothetical protein	G4KNP7	Staphylococcus_phage	1.3e-76	100.0
WP_001622114.1\|2001638_2001839_-	DUF1514 family protein	A0A2I6PDV9	Staphylococcus_phage	4.0e-28	98.5
WP_000595265.1\|2001838_2001988_-	transcriptional activator RinB	A0A1W6JPZ2	Staphylococcus_phage	4.8e-18	100.0
WP_000592207.1\|2001984_2002371_-	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
WP_000195803.1\|2002367_2002574_-	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
WP_001282074.1\|2002570_2002816_-	hypothetical protein	A0A2I6PDW7	Staphylococcus_phage	5.0e-36	100.0
WP_001066447.1\|2002852_2003389_-	dUTP diphosphatase	A0A0H3U2Z8	Staphylococcus_phage	7.2e-96	100.0
WP_000714403.1\|2003381_2003552_-	hypothetical protein	A0A0H3U4U6	Staphylococcus_phage	8.2e-22	100.0
WP_001065097.1\|2003538_2003793_-	DUF1024 family protein	A0A0H3U469	Staphylococcus_phage	5.0e-39	100.0
WP_000131370.1\|2003807_2004050_-	hypothetical protein	Q4ZDP7	Staphylococcus_virus	2.1e-39	95.0
WP_000101288.1\|2004053_2004422_-	hypothetical protein	A0A0H3U2T3	Staphylococcus_phage	2.0e-49	100.0
WP_000401960.1\|2004434_2004839_-	RusA family crossover junction endodeoxyribonuclease	A0EWX6	Staphylococcus_phage	1.9e-72	100.0
WP_000338530.1\|2004847_2005066_-	hypothetical protein	A0A2I6PDG4	Staphylococcus_phage	1.0e-37	100.0
WP_000148321.1\|2005072_2005966_-	DnaD domain-containing protein	A0A2I6PDG7	Staphylococcus_phage	5.5e-141	99.3
WP_000610648.1\|2005995_2006466_-	single-stranded DNA-binding protein	A0EWX3	Staphylococcus_phage	1.3e-80	98.7
WP_073394849.1\|2006466_2007084_-	MBL fold metallo-hydrolase	A0A2I6PDI9	Staphylococcus_phage	9.1e-87	100.0
WP_000138475.1\|2007164_2008085_-	recombinase RecT	A0A2I6PDH5	Staphylococcus_phage	2.3e-166	100.0
WP_000700555.1\|2008086_2010030_-	AAA family ATPase	S4V9K6	Staphylococcus_phage	0.0e+00	100.0
WP_001205732.1\|2010038_2010302_-	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	7.7e-43	100.0
WP_000291510.1\|2010310_2010571_-	DUF1108 family protein	A0A1P8L6F5	Staphylococcus_phage	5.2e-44	100.0
WP_000165371.1\|2010575_2010878_-	DUF2482 family protein	A0A1P8L6F8	Staphylococcus_phage	7.0e-48	100.0
WP_000048129.1\|2010972_2011134_-	DUF1270 family protein	A0A1P8L6G0	Staphylococcus_phage	1.9e-20	100.0
WP_001120201.1\|2011130_2011454_-	DUF771 domain-containing protein	A0A075LYF5	Staphylococcus_phage	3.0e-57	100.0
WP_000762519.1\|2011508_2011889_+	DUF2513 domain-containing protein	Q9T1Z5	Staphylococcus_phage	3.4e-68	99.2
WP_001148862.1\|2011875_2012073_-	hypothetical protein	O80075	Staphylococcus_phage	3.5e-24	87.7
WP_001148605.1\|2012088_2012841_-	phage antirepressor KilAC domain-containing protein	M9NTH5	Staphylococcus_phage	1.1e-139	100.0
WP_000128907.1\|2012891_2013221_+	hypothetical protein	M9NS98	Staphylococcus_phage	2.7e-53	100.0
WP_001025404.1\|2013209_2013425_-	DUF2829 domain-containing protein	A0A0H3U4C7	Staphylococcus_phage	4.8e-35	100.0
WP_000854074.1\|2013421_2013703_-	helix-turn-helix transcriptional regulator	A0A2I6PF09	Staphylococcus_phage	4.6e-38	96.5
WP_001801500.1\|2013699_2013873_-	hypothetical protein	NA	NA	NA	NA
WP_001031454.1\|2013835_2014549_+	helix-turn-helix transcriptional regulator	M9NUL0	Staphylococcus_phage	1.2e-130	100.0
WP_000759682.1\|2014564_2015497_+	ATP-dependent helicase	A0A2I6PEZ7	Staphylococcus_phage	5.7e-173	100.0
WP_000591749.1\|2015502_2015844_+	hypothetical protein	A0A2I6PF04	Staphylococcus_phage	4.6e-56	100.0
WP_000705248.1\|2016047_2016230_+	hypothetical protein	M9NSW6	Staphylococcus_phage	4.1e-27	100.0
WP_000825947.1\|2016329_2016794_+	hypothetical protein	A0EWV3	Staphylococcus_phage	1.1e-28	100.0
WP_000857191.1\|2016852_2017890_+\|integrase	site-specific integrase	A0EWV2	Staphylococcus_phage	9.1e-180	100.0
WP_000595326.1\|2019008_2020025_-	bi-component leukocidin LukGH subunit G	A0A2I6PER8	Staphylococcus_phage	5.1e-26	29.3
WP_000791419.1\|2020046_2021099_-	bi-component leukocidin LukGH subunit H	A0A2I6PER8	Staphylococcus_phage	2.4e-34	31.8
2032144:2032168	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022226

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection