CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022356	Haemophilus influenzae KR494, complete sequence	2 crisprs	RT,cas14j,cas3,DEDDh,DinG	0	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022356_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022356_1

299994-300083

Orphan

Consensus_repeat	Method
AAACAATTGTGAGATATTTTGGTGGGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022356_1

>merge|NC_022356|1|299994-300083|CRISPRCasFinder
AAACAATTGTGAGATATTTTGGTGGGCTTCAGTAGTTGTAGGGTGGGCTTTAGCCCACCAACAAACAATCGTGAGATATTTTGGTGGGCT

>NC_022356|1|1|299994-300083|CRISPRCasFinder
AAACAATTGTGAGATATTTTGGTGGGCT	TCAGTAGTTGTAGGGTGGGCTTTAGCCCACCAAC
AAACAATCGTGAGATATTTTGGTGGGCT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022356.1\|WP_021034583.1\|305948_306383_+\|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl\|CDD\|235383
NC_022356.1\|WP_021034580.1\|302318_303977_+\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|224055
NC_022356.1\|WP_021034579.1\|300580_302326_+\|ABC-transporter-ATP-binding-protein/permease	unknown	unknown	gnl\|CDD\|227321
NC_022356.1\|WP_021034568.1\|289023_290307_-\|lipid-IV(A)-3-deoxy-D-manno-octulosonic-acid-transferase	unknown	unknown	gnl\|CDD\|235589
NC_022356.1\|WP_021034573.1\|292717_293269_-\|Sua5/YciO/YrdC/YwlC-family-protein	unknown	unknown	gnl\|CDD\|182603
NC_022356.1\|WP_021034585.1\|306884_307361_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|178851
NC_022356.1\|WP_021034575.1\|293830_295747_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|236729
NC_022356.1\|WP_005650820.1\|305194_305413_+\|cell-division-protein-ZapB	unknown	unknown	gnl\|CDD\|225616
NC_022356.1\|WP_021034584.1\|306647_306815_+\|hypothetical-protein	unknown	unknown	unknown
NC_022356.1\|WP_021034576.1\|296812_299788_-\|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor	unknown	unknown	gnl\|CDD\|273808
NC_022356.1\|WP_021034570.1\|291130_291694_-\|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl\|CDD\|377025
NC_022356.1\|WP_021034578.1\|300363_300528_+\|hypothetical-protein	unknown	unknown	unknown
NC_022356.1\|WP_005694481.1\|296192_296552_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|227024
NC_022356.1\|WP_021034572.1\|291907_292714_-\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|161904
NC_022356.1\|WP_005650837.1\|295903_296200_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376540
NC_022356.1\|WP_021034569.1\|290369_291134_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133005
NC_022356.1\|WP_021034577.1\|300150_300315_+\|hypothetical-protein	unknown	unknown	unknown
NC_022356.1\|WP_021034582.1\|305511_305952_+\|FMN-binding-protein-MioC	unknown	unknown	gnl\|CDD\|181608
NC_022356.1\|WP_021034581.1\|304031_305033_-\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|129430
NC_022356.1\|WP_021034574.1\|293284_293821_-\|topoisomerase-DNA-binding-C4-zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|223625

Protein	Function_ID	Function_description	E-value
NC_022356.1\|WP_021034583.1\|305948_306383_+\|D-tyrosyl-tRNA(Tyr)-deacylase	gnl\|CDD\|235383	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional.	3.98886e-97
NC_022356.1\|WP_021034580.1\|302318_303977_+\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.63249e-125
NC_022356.1\|WP_021034568.1\|289023_290307_-\|lipid-IV(A)-3-deoxy-D-manno-octulosonic-acid-transferase	gnl\|CDD\|235589	PRK05749, PRK05749, 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed.	0
NC_022356.1\|WP_021034573.1\|292717_293269_-\|Sua5/YciO/YrdC/YwlC-family-protein	gnl\|CDD\|182603	PRK10634, PRK10634, L-threonylcarbamoyladenylate synthase type 1 TsaC.	3.02868e-86
NC_022356.1\|WP_021034585.1\|306884_307361_-\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|178851	PRK00084, ispF, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed.	1.89655e-105
NC_022356.1\|WP_021034575.1\|293830_295747_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|236729	PRK10636, PRK10636, putative ABC transporter ATP-binding protein; Provisional.	0
NC_022356.1\|WP_005650820.1\|305194_305413_+\|cell-division-protein-ZapB	gnl\|CDD\|225616	COG3074, COG3074, Uncharacterized protein conserved in bacteria [Function unknown].	7.07035e-14
NC_022356.1\|WP_021034576.1\|296812_299788_-\|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor	gnl\|CDD\|273808	TIGR01786, hemoglobin-haptoglobin-binding_protein, TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein. This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	4.40697e-80
NC_022356.1\|WP_021034570.1\|291130_291694_-\|DNA-3-methyladenine-glycosylase-I	gnl\|CDD\|377025	pfam03352, Adenine_glyco, Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.	9.94776e-117
NC_022356.1\|WP_005694481.1\|296192_296552_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|227024	COG4679, COG4679, Phage-related protein [Function unknown].	2.80135e-42
NC_022356.1\|WP_021034572.1\|291907_292714_-\|shikimate-dehydrogenase	gnl\|CDD\|161904	TIGR00507, Shikimate_dehydrogenase, shikimate dehydrogenase. This model finds proteins from prokaryotes and functionally equivalent domains from larger, multifunctional proteins of fungi and plants. Below the trusted cutoff of 180, but above the noise cutoff of 20, are the putative shikimate dehydrogenases of Thermotoga maritima and Mycobacterium tuberculosis, and uncharacterized paralogs of shikimate dehydrogenase from E. coli and H. influenzae. The related enzyme quinate 5-dehydrogenase scores below the noise cutoff. A neighbor-joining tree, constructed with quinate 5-dehydrogenases as the outgroup, shows the Clamydial homolog as clustering among the shikimate dehydrogenases, although the sequence is unusual in the degree of sequence divergence and the presence of an additional N-terminal domain. [Amino acid biosynthesis, Aromatic amino acid family].	6.73201e-134
NC_022356.1\|WP_005650837.1\|295903_296200_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	4.09836e-10
NC_022356.1\|WP_021034569.1\|290369_291134_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133005	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide. UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.	3.59052e-93
NC_022356.1\|WP_021034579.1\|300580_302326_+\|ABC-transporter-ATP-binding-protein/permease	gnl\|CDD\|227321	COG4988, CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
NC_022356.1\|WP_021034582.1\|305511_305952_+\|FMN-binding-protein-MioC	gnl\|CDD\|181608	PRK09004, PRK09004, FMN-binding protein MioC; Provisional.	2.23102e-88
NC_022356.1\|WP_021034581.1\|304031_305033_-\|class-II-fructose-bisphosphatase	gnl\|CDD\|129430	TIGR00330, Fructose-16-bisphosphatase_class_2, fructose-1,6-bisphosphatase, class II. This model represents GlpX, one of three classes of bacterial fructose-1,6-bisphosphatases. This form is homodimeric and Mn2+-dependent, and only very distantly related to the class I fructose-1,6-bisphosphatase, the product of the fbp gene, which is homotetrameric and Mg2+-dependent. A third class is found as one of two types in Bacillus subtilis. In E. coli, GlpX is found in the glpFKX operon together with a glycerol update protein and glycerol kinase. [Energy metabolism, Pentose phosphate pathway].	0
NC_022356.1\|WP_021034574.1\|293284_293821_-\|topoisomerase-DNA-binding-C4-zinc-finger-domain-containing-protein	gnl\|CDD\|223625	COG0551, TopA, Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair].	1.22202e-31

>NC_022356.1|WP_021034576.1|296812_299788_-|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor
MTNFRLNVLAYSVMLGLTASVAYAEPTNQPTNQPTNQPTNQPTNQPTNQNSNASEQLEQINVSGSTENTDTKAPPKIAETVKTAKTLEREQANNIKDIVKYETGVTVVEAGRFGQSGFAIRGVDENRVAINIDGLRQAETLSSQGFKELFEGYGNFNNTRNGAEIETLKEVNITKGADSIKNGSGSLGGSVIYKTKDARDYLLNKDYYVSYKKGYATENNQSFNTLTLAGRYKKFDVLVVTTSRNGHELENYGYKNYNDKIQGKKREKADPYKIEQDSTLLKLSFNPTENHRFTFAADLYEHRSRGQDLSYTLKYQRSGYETPEVESRHTNDKTKRRNISFSYENFSQTPFWDTLKLTYSDQRIKTRARTDEYCDAGVRHCEGTDNPTGLKLTDGKITRRDGSELQFEKKNKNNNDEYNFNRFIDTDGQVIDKGIKLGRTSETWYDCSIFNCDDKKIKVFEGNNSYGHDGKWKEVELETKTLNGKKFAKIKDTGYKIRSILPSSPGYLERLWQERDLDTNTQQLNLDLTKDFKTWHIEHNLQYGGSYNTAMKRMVNRAGNDAYDVQWWAERTLGFKTSWYAPPETPETCEGSSTWNANLCPRVDPEFSYLLPIKTTGKSVYLFDNFVITDYLSFDLGYRYDNIHYQPKYKHGITPKLPDDIVKGLFIPLKQNAKTDEDIKKNVQQNIDYIAKQNKKYKAHSYSFVSTIDPTSFLRLQLKYSKGFRTPTSDEMYFTFKHPDFTILPNTDLKPEIAKTREIAFTLHNDDWGFISTSLFKTNYKNFIDLIFKGEQDFPLVSGGSSLPFSLYQNINRDNASLKGIEINSKVFLGKMAKFMDGFNLSYKYTYQKGRMNGNIPMNAIQPKTMVYGLGYDHPSQKFGFNFYTTHVASKNPEDTYDIYAKDKNQTNTSIKWRSKSYTILDLIGYVQPIKNLTIRAGVYNLTNRKYITWDSARSIRSFGTSNVIDQSTGLGINRFYAPGRNYKMSVQFEF
>NC_022356.1|WP_005694481.1|296192_296552_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE
>NC_022356.1|WP_005650837.1|295903_296200_-|helix-turn-helix-transcriptional-regulator
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKLLAPLGKTLSIVPLRVKNA
>NC_022356.1|WP_021034575.1|293830_295747_-|ABC-transporter-ATP-binding-protein
MIIFSNLSLKRGQTELLENASAMINPKQKVGLVGKNGCGKSSLFALLKKELMPEGGEVNYPANWRVSWVNQETPALDISAIDYVIQGDREYCRLQQELERANERNDGNAIARIHGQLETLDAWTIQSRAASLLHGLGFSQEETIQPVKAFSGGWRMRLNLAQALLCPSDLLLLDEPTNHLDLDAVIWLERWLVQYQGTLVLISHDRDFLDPIVTKILHIENQKLNEYTGDYSSFEVQRATKLAQQTAMYRQQQQKISHLQKYIDRFKAKATKAKQAQSRMKALERMELIAPAYVDNPFTFEFRPPQSLPNPLVMIEQASAGYGSGESAVEILSKIKLNLVPGSRIGLLGKNGAGKSTLIKLLAGELTALSGTVQLAKGVQLGYFAQHQLDTLRADESALWHMQKLAPEQTEQQVRDYLGSFAFHGDKVNQAVKSFSGGEKARLVLALIVWQRPNLLLLDEPTNHLDLDMRQALTEALVDYEGSLVVVSHDRHLLRNTVEEFYLVHDKKVEEFKGDLEDYQKWLSEQNSTSENKVSEKVGDNENSVQNRKEQKRREAELRQQTAPLRKKITQLEEKMNKFSSELANIENQLADAELYNAENKEKLTALLAQQVDVKKALDDVETEWMTAQEELEEMLQA
>NC_022356.1|WP_021034574.1|293284_293821_-|topoisomerase-DNA-binding-C4-zinc-finger-domain-containing-protein
MNQSLFHHSKQQEYCPQCGAPLQIKQGKKGLFLGCSAYPECDYLRPLQRSEHKVLKTLDEICPKCSNLLQLKQGSFGMFIGCSHYPECDFVVREESESEEKIACPECKTGHLISRRGRQGKIFYGCDNFPKCKFSLPAKPYAVPCPTCHFPLSLLKSENGEKQIFQCANKTCRHIFEQ
>NC_022356.1|WP_021034573.1|292717_293269_-|Sua5/YciO/YrdC/YwlC-family-protein
MNREQIAETLRQNQVVAYPTEAVFGLGCNPQSESAVKKLLDLKQRPVEKGLILVAPSLDFFRPFVDFEQINDEQLSRLQGKYERPTTWIVPAKSTTPHFLTGKFDSIAVRLCDHPSVKALCEITGFALTSTSANLTGEPPCRIADEVRSQFGSDFPVLDEIVGGALNPSEIRDLRTNQLFRQG
>NC_022356.1|WP_021034572.1|291907_292714_-|shikimate-dehydrogenase
MDLYAVWGNPIVQSKSPLIQNKLAAQTHQAIEYIAKLGDLDTFEHQLLAFFDEGAKGCNITSPFKERAYQLADEYSQRAKLAEACNTLKKLDDGKLYADNTDGIGLVTDLQRLNWLHPNQRILILGAGGATKGVLLPLLQAQQNIMLANRTFSKAKELAERFQPYGNIQAVSMDSIPLQTYDVVINATSAGLSGGTASVDAEILRLGSAFYDMQYAKGTDTPFIALCKSLGLTNVSDGFGMLVAQAAHSFHLWRGIMPDFVAVYEQLK
>NC_022356.1|WP_021034570.1|291130_291694_-|DNA-3-methyladenine-glycosylase-I
MQQITRCPWVGEQPIYIDYHDKEWGKPEFDSQKLFEKICLEGQQAGLSWITVLKKRESYREAFHQFDPKKIAKMTALDIDDCMKNAGLIRHRAKLEAIVKNAKAYLAMEKCGENFSDFVWSFVNHKPIVNDVPDLRTVPAKTEASKALSKALKKRGFVFVGETTCYAFMQSMGLVDDHLNNCPCKTR
>NC_022356.1|WP_021034569.1|290369_291134_+|glycosyltransferase-family-2-protein
MPTISVAMIIKNEAQDLANCLDTVKDWVDEIIILDSGSTDNTKEIALSYGAKFYENSNWQGFGKQRQLAQQYVTSDYVLWLDADERVTLKLQQAILSAVKNDRENTVYEIPRVSEVFGREIRHSGWYPDYVVRLYRTNYAQYNDSLVHEKVEFPAGTKVEKLTGDLEHFTYKSIHHYLVKSAGYAKAWADQRQAKGKKATLWQGISHALGCFVKMYLLKAGFLDGKQGFLLAVLSAHSTFVKYADLWERDQHKH
>NC_022356.1|WP_021034568.1|289023_290307_-|lipid-IV(A)-3-deoxy-D-manno-octulosonic-acid-transferase
MWRFFYTSLLLICQPLILCFIGLLSVKSPRYRQRLAERYGFYGNASCPPPQGIFIHAASVGEVIAATPLVRQLQQDYPHLSITFTTFTPTGSERVKATFGDSVFHYYLPLDLPFSIHRFINFVQPKLCIVMETELWPNLIHQLFLRNIPFVIANARLSARSAHRYGKIKAHLQTMWSQISLIAAQDNISGKRYATLGYPKEKLNITGNIKYDLNTNDELLRKIDSLRTLWKQDRPIWIAASTHNGEDEIILKSHRALLAKYPNLLLLLVPRHPERFNMVADLLKKEKFQFIRRSKNELPNENTQVILGDSMGELMLMYGISDIAFVGGSLVKHGGHNPLEPLAFKMPVITGKHTFNFPEIFRMLVEVQGVLEVNSTADALERAVEALLNSKEAREHLGNAGYEVLMENRGALQRLLDLLKPYLERNV
>NC_022356.1|WP_021034577.1|300150_300315_+|hypothetical-protein
MMIDKRLINTVSDSKKWIGVTVLWNWVALVVVGWALAHQQTIVRYFGGLKPTLR
>NC_022356.1|WP_021034578.1|300363_300528_+|hypothetical-protein
MMIDKRLINTVADSKKWIGITVLWNWVALVVVGWASAHHQTVVRYFGGLKPTLH
>NC_022356.1|WP_021034579.1|300580_302326_+|ABC-transporter-ATP-binding-protein/permease
MMIDKRLINTVADSKKWIGVTVLWNWVALVGGIISAVVFSYILQAAYFHELSPLSAVIFGILLIAALALRAFAGKKSVQASYFASTKVKHELRSLIYRKLASMPLNQVNQQSTSSIIQVASEGVEQLEIYFGRYLPQLFYSLLAPLTLFAFLIFFSFKTAIILLICVPLIPMSIIAVNKIAKKLLAKYWSIYVGLGSSFLDNLQGLITLKIYQDDAYKAKAMDKEAEHFRKITMKVLTMQLNSVSLMDLLAYGGAAIGILTALLQFQDAQLSVLGVILFILLSSEFFIPLRLLGSFFHVAMNGKAASDKIFTLLDTPVEIQQSAVDFEAKNNLQVEIKDLHFSYSEEKPAITGLDLSILPNQLSVFVGKSGCGKSTLVSLLMGFNKAQQGEILFNGQNALNIDRTSFYQKVSLVSHSSYVFKGSLRENMTMAKIDATDEQIYACLEQVNLAQFVRENGGLDMQLLSRGANLSGGQIQRLALARALLHNAELYIFDEATSNIDVESEEIILQFIQQFKQQKTIVMISHRLANAVNADCINVLDQGKLIEQGTHESLMAKQGAYAEMFQQQKDLEQIREVANA
>NC_022356.1|WP_021034580.1|302318_303977_+|thiol-reductant-ABC-exporter-subunit-CydC
MRKNGFVVMGHLLKLVTPLAHIMAFTITMGTLGFLAAIFIMVFGAMGLVNLLNFDTHLSFSGILTALIVLAVARGVLRYLEQMSGHYIAFKLLALLRDKVFSSLRRLAFVKLQDKQAGQLVSLVTNDIELLEVFYAHTIAPIMIAFFTSAILLLVFAHLSGWFVVVALAAYLTVGVILPIITTKLAREDGRRYRELVGEMNDFFLDSVRGMKEIQLFGYAQQRLAEIQQRSQKIDTAFERIKDQEAKVRVYTEVAVSVFNIIMLFTGLILFSLDKIDFAAFLIGVILLMSSYGPVIALSNLSSNLLQTLASGERVLSLLAEEPELKDVESAVDLKDVSRIDVENLNFAYGEEQILSDVSLSVKKGEILGIHGRSGSGKSTLLKLLMRFYDPKSGSIKINGETLPNINTRSLRDNMAYITQQTYIFNETIEENIRLARRDATLEEIMEAAKKASIHDFILSLPQGYQTKMTELGGNLSDGEKQRIGIARAFLHNAPIILLDEPTSNLDSLNEAMILKSLLNVKAEKLIILVSHRQSTMAICDQVIGIENGRMS
>NC_022356.1|WP_021034581.1|304031_305033_-|class-II-fructose-bisphosphatase
MNRALAIEFSRVTEAAALAAYTWLGRGDKNAADDAAVKAMRYMLNLIHMDAEIVIGEGEIDEAPMLYIGEKVGSGLGELVSIAVDPIDGTRMTAMGQSNAISVLAAGGKNTFLKAPDMYMEKLVVGSNVKGIIDLNLPLEQNLRRIASKLGKSLSDLTVMVLAKPRHEAIIKQIHNLGAKVLAIPDGDVAGSVLCCLPDAEVDLLYGIGGAPEGVAAAAAIRALGGDMQARLIPRNEVKGDTEENKKIAANEIQRCAALGVKVNEVLKLGDLVRDDNLVFTATGITNGDLLKGISRKGNLANTETILIQGKSRTIRKIQSIHYLDDLYKILNI
>NC_022356.1|WP_005650820.1|305194_305413_+|cell-division-protein-ZapB
MSLEILDQLEEKIKQAVETIQLLQLEVEELKEKNAESQRNIENLQTENEQLKNEHRNWQEHIRSLLGKFDNV
>NC_022356.1|WP_021034582.1|305511_305952_+|FMN-binding-protein-MioC
MHICILSGSTLGGAEYVAEHLNDVLETQGFSTALFHGPNLSDIENEKIWLIVTSTHGAGELPDNLKPLFDELANSQKDFSDVRFAVVGLGNSDYDTFCYAAEQVEQTLQAKSAVKICETLKIDVLNVDDQESYAEEWLPSFIEGLK
>NC_022356.1|WP_021034583.1|305948_306383_+|D-tyrosyl-tRNA(Tyr)-deacylase
MIALIQRVSQAKVDVNGETIGQIGKGLLVLLGVEKEDNQEKADKLAEKVLNYRIFSDENDKMNLNVQQVQGELLIVSQFTLAADTQKGLRPSFSKGASPALANELYEYFIQKCGEKLPVSTGQFAADMQVSLTNDGPVTFWLNV
>NC_022356.1|WP_021034584.1|306647_306815_+|hypothetical-protein
MSDNSPPNPIGKLHSAMPNGANFLSCAETFSFIVCIINYKLTVQEYGMPLLWLKL
>NC_022356.1|WP_021034585.1|306884_307361_-|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MIRIGHGFDVHAFGEDRPLIIGGVEVPYHTGFIAHSDGDVALHALTDAILGAAALGDIGKLFPDTDMQYKNADSRGLLREAFRQVQEKGYKIGNVDVTIIAQAPKMRPHIDAMRAKIAEDLQCDIEQVNVKATTTEKLGFTGRQEGIACEAVALLIRQ

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Crispr_ID: NC_022356_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022356_2

1278890-1279001

Orphan

Consensus_repeat	Method
TACCCACAGTTAATTTATGTTTATAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022356_2

>merge|NC_022356|2|1278890-1279001|CRISPRCasFinder
TACCCACAGTTAATTTATGTTTATAGTAGTTCCATCTGGGGAACATCAAATCACTCCAACAAGTGGCACTTCCCGTGGGTAAGTGTACCCACGGTTAATTTATGTTTATAGT

>NC_022356|2|2|1278890-1279001|CRISPRCasFinder
TACCCACAGTTAATTTATGTTTATAGT	AGTTCCATCTGGGGAACATCAAATCACTCCAACAAGTGGCACTTCCCGTGGGTAAGTG
TACCCACGGTTAATTTATGTTTATAGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022356.1\|WP_021035302.1\|1270742_1272041_+\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|235037
NC_022356.1\|WP_021035298.1\|1265472_1267194_-\|acetolactate-synthase-3-large-subunit	unknown	unknown	gnl\|CDD\|168717
NC_022356.1\|WP_005671572.1\|1282121_1282409_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226290
NC_022356.1\|WP_021035312.1\|1287074_1287704_+\|outer-membrane-lipoprotein-LolB	unknown	unknown	gnl\|CDD\|129639
NC_022356.1\|WP_021035311.1\|1285761_1287012_+\|multifunctional-CCA-addition/repair-protein	unknown	unknown	gnl\|CDD\|182810
NC_022356.1\|WP_021035307.1\|1279066_1280113_-\|inorganic-triphosphatase	unknown	unknown	gnl\|CDD\|225569
NC_022356.1\|WP_021035310.1\|1285143_1285755_+\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|225645
NC_022356.1\|WP_021035303.1\|1272126_1273467_-\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NC_022356.1\|WP_021035304.1\|1273527_1274145_-\|outer-membrane-lipoprotein-chaperone-LolA	unknown	unknown	gnl\|CDD\|129638
NC_022356.1\|WP_021035299.1\|1267460_1268981_-\|Na+/H+-antiporter-NhaC-family-protein	unknown	unknown	gnl\|CDD\|224671
NC_022356.1\|WP_005653243.1\|1282447_1282888_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NC_022356.1\|WP_005647270.1\|1283110_1283791_+\|TIGR00153-family-protein	unknown	unknown	gnl\|CDD\|272932
NC_022356.1\|WP_021035305.1\|1274162_1276922_-\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|236669
NC_022356.1\|WP_021035306.1\|1277482_1278859_-\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|273067
NC_022356.1\|WP_005653255.1\|1276923_1277403_-\|leucine-responsive-transcriptional-regulator-Lrp	unknown	unknown	gnl\|CDD\|183009
NC_022356.1\|WP_041175347.1\|1280432_1281149_-\|DUF2063-domain-containing-protein	unknown	unknown	gnl\|CDD\|225760
NC_022356.1\|WP_021035300.1\|1269431_1269836_+\|H-NS-histone-family-protein	unknown	unknown	gnl\|CDD\|225468
NC_022356.1\|WP_021035309.1\|1283815_1285078_+\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|376541
NC_022356.1\|WP_021035301.1\|1269906_1270743_+\|formyltetrahydrofolate-deformylase	unknown	unknown	gnl\|CDD\|235676
NC_022356.1\|WP_005647267.1\|1281138_1282062_-\|DUF692-family-protein	unknown	unknown	gnl\|CDD\|225761

Protein	Function_ID	Function_description	E-value
NC_022356.1\|WP_021035302.1\|1270742_1272041_+\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|235037	PRK02427, PRK02427, 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional.	0
NC_022356.1\|WP_021035298.1\|1265472_1267194_-\|acetolactate-synthase-3-large-subunit	gnl\|CDD\|168717	PRK06882, PRK06882, acetolactate synthase 3 large subunit.	0
NC_022356.1\|WP_005671572.1\|1282121_1282409_-\|hypothetical-protein	gnl\|CDD\|226290	COG3767, COG3767, Uncharacterized low-complexity protein [Function unknown].	3.61169e-14
NC_022356.1\|WP_021035312.1\|1287074_1287704_+\|outer-membrane-lipoprotein-LolB	gnl\|CDD\|129639	TIGR00548, Outer-membrane_lipoprotein_lolB_precursor., outer membrane lipoprotein LolB. This protein, LolB, is known so far only in the gamma and beta subdivisions of the Proteobacteria. It is a processed, lipid-modified outer membrane protein. It is required in E. coli for insertion of the major outer lipoprotein (Lpp) into the outer membrane. Lpp is transferred to LolB from the carrier protein LolA in the periplasm. Previously, this protein was thought to play in role in 5-aminolevulinic acid synthesis and was designated HemM. [Protein fate, Protein and peptide secretion and trafficking].	1.16378e-102
NC_022356.1\|WP_021035311.1\|1285761_1287012_+\|multifunctional-CCA-addition/repair-protein	gnl\|CDD\|182810	PRK10885, cca, multifunctional CCA addition/repair protein.	0
NC_022356.1\|WP_021035307.1\|1279066_1280113_-\|inorganic-triphosphatase	gnl\|CDD\|225569	COG3025, COG3025, Uncharacterized conserved protein [Function unknown].	4.05388e-136
NC_022356.1\|WP_021035310.1\|1285143_1285755_+\|SH3-domain-containing-protein	gnl\|CDD\|225645	COG3103, COG3103, SH3 domain protein [Signal transduction mechanisms].	6.99668e-85
NC_022356.1\|WP_021035303.1\|1272126_1273467_-\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NC_022356.1\|WP_021035304.1\|1273527_1274145_-\|outer-membrane-lipoprotein-chaperone-LolA	gnl\|CDD\|129638	TIGR00547, Outer-membrane_lipoprotein_carrier_protein, periplasmic chaperone LolA. This protein, LolA, is known so far only in the gamma and beta subdivisions of the Proteobacteria. The E. coli major outer lipoprotein (Lpp) of E. coli is released from the inner membrane as a complex with this chaperone in an energy-requiring process, and is then delivered to LolB for insertion into the outer membrane. LolA is involved in the delivery of lipoproteins generally, rather than just Lpp, and is an essential protein in E. coli, unlike Lpp itself. [Protein fate, Protein and peptide secretion and trafficking].	5.31137e-120
NC_022356.1\|WP_021035299.1\|1267460_1268981_-\|Na+/H+-antiporter-NhaC-family-protein	gnl\|CDD\|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	1.46027e-108
NC_022356.1\|WP_005653243.1\|1282447_1282888_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	6.58428e-26
NC_022356.1\|WP_005647270.1\|1283110_1283791_+\|TIGR00153-family-protein	gnl\|CDD\|272932	TIGR00153, UPF0111_protein_MTH_1689, TIGR00153 family protein. An apparent homolog with a suggested function is Pit accessory protein from Sinorhizobium meliloti, which may be involved in phosphate (Pi) transport. [Hypothetical proteins, Conserved].	4.11242e-90
NC_022356.1\|WP_021035305.1\|1274162_1276922_-\|DNA-translocase-FtsK	gnl\|CDD\|236669	PRK10263, PRK10263, DNA translocase FtsK; Provisional.	0
NC_022356.1\|WP_021035306.1\|1277482_1278859_-\|DNA-repair-protein-RadA	gnl\|CDD\|273067	TIGR00416, DNA_repair_protein_RadA_homolog, DNA repair protein RadA. The gene protuct codes for a probable ATP-dependent protease involved in both DNA repair and degradation of proteins, peptides, glycopeptides. Also known as sms. Residues 11-28 of the SEED alignment contain a putative Zn binding domain. Residues 110-117 of the seed contain a putative ATP binding site both documented in Haemophilus (SP:P45266) and in Listeria monocytogenes (SP:Q48761) . for E.coli see ( J. BACTERIOL. 178:5045-5048(1996)). [DNA metabolism, DNA replication, recombination, and repair].	0
NC_022356.1\|WP_005653255.1\|1276923_1277403_-\|leucine-responsive-transcriptional-regulator-Lrp	gnl\|CDD\|183009	PRK11169, PRK11169, leucine-responsive transcriptional regulator Lrp.	3.20716e-107
NC_022356.1\|WP_041175347.1\|1280432_1281149_-\|DUF2063-domain-containing-protein	gnl\|CDD\|225760	COG3219, COG3219, Uncharacterized protein conserved in bacteria [Function unknown].	8.80809e-127
NC_022356.1\|WP_021035300.1\|1269431_1269836_+\|H-NS-histone-family-protein	gnl\|CDD\|225468	COG2916, Hns, DNA-binding protein H-NS [General function prediction only].	6.03438e-38
NC_022356.1\|WP_021035309.1\|1283815_1285078_+\|inorganic-phosphate-transporter	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	7.38614e-53
NC_022356.1\|WP_021035301.1\|1269906_1270743_+\|formyltetrahydrofolate-deformylase	gnl\|CDD\|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	1.4006e-175
NC_022356.1\|WP_005647267.1\|1281138_1282062_-\|DUF692-family-protein	gnl\|CDD\|225761	COG3220, COG3220, Uncharacterized protein conserved in bacteria [Function unknown].	2.91612e-156

>NC_022356.1|WP_021035306.1|1277482_1278859_-|DNA-repair-protein-RadA
MAKATKTAYVCNDCGAEFSRWQGQCSACKAWNTITEVRLISTAKSKNDRFSGYAGETQAKIQTLSEISLQETPRFSSGFNELDRVLGGGIVPGSAILIGGHPGAGKSTLLLQVMCGLAKNMTALYVTGEESLQQVAMRASRLGLSNDQLKMLSETSVEQICNLADQLKPQIIVVDSIQVMHLADIQSSPGSVAQVRECASFLTRYAKTRQVAIIMVGHVTKDGTLAGPKVLEHAIDCSLLLEGEADSRYRTLRSHKNRFGAVNELGVFGMTEQGLREVKNPSAIFLSRGDEITSGSSVMVLWEGTRPLLVEIQALVDHSMLANPRRVAVGLEQNRLSLLLAVLHRHGGLQMADQDVFVNVVGGVKVSETSADLALLLALISSFRNRPLPQDLVIFGEVGLAGEIRPVPSGQERISEAAKHGFKRAIVPFGNKPKSAVENMQVFTVKKLTDALAVLDNL
>NC_022356.1|WP_005653255.1|1276923_1277403_-|leucine-responsive-transcriptional-regulator-Lrp
MEKKRNKALDAIDIKILNELQRNGKISNIDLSRKVGLSPTPCLERVKRLEKQGVIMGYRALLNPELLDAPLLVIVEITLVRGKPDVFEEFNAAIQELDEIQECHLVSGDFDYLLKTRVADMAEYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLVLK
>NC_022356.1|WP_021035305.1|1274162_1276922_-|DNA-translocase-FtsK
MIKQITERFTPRQYLAEFLLGLTALFGLYLIVAWSSYTPLDNSWATASAYENTINKVGTFGAWIIDLFFVFFGYVAHIIPFTAFLVPIYLLKTKAVKHLSCTRIILRSFGFIMLIIGLCVVSMLLLSSNTFYLSGGVLGGSLVVNWFYPVLGKFGSILIGFVFALIGFIFCSGASLIRLIVAFYYWLTMKNEQSENAEQEKSTEELEQIVIVKSDRSETENLDQNHLNVEQNSEIETVKPSLEAENISIDASSSHLINISGLNPEVSIKSEYELANEDSEKPQFSFGFDSESLPSVNLSSDSDEQRVSKNDFVAVWNKPVKTVVQEDLAINQSADDFTQVSLLTNDEMPTVSLKSTSDTEMADNHFAAQVDEKVDLEKDEVKFSVSLQNNVDAIELDKNQEPNYKGYSGSLIHPAFQQQTTKREKPSTPLPSLDLLSKHPPSEQRITPDEIMETSQRIEQQLRNFNVKASVKDVLVGPVVTRYELELQPGVKASKVTSIDTDLARALMFRSIRVAEVIPGKPYIGIETPNLHRQMVPLRDVLDSNEFRDSKATLPIALGKDISGKPVIVDLAKMPHLLVAGSTGSGKSVGVNTMILSLLYRVQPEDVKFIMIDPKVVELSVYNDIPHLLTPVVTDMKKAANALRWCVDEMERRYQLLSALRVRNIEGFNEKIDEYDAMGMPVPNPIWRQGDTMDAMPPALKKLSYIVVIVDEFADLMMVAGKQIEELIARLAQKARAIGIHLILATQRPSVDVITGLIKANIPSRIAFTVASKIDSRTILDQGGAEALLGRGDMLYSGQGSSDLIRVHGAYMSDDEVINIADDWRARGKPDYIDGILESVDDEDNAEKGISSGGELDPLFDEVMDFVINTGTTSVSSIQRKFSVGFNRAARIMDQMEEQGIVSPMQNGKREILSRRPEY
>NC_022356.1|WP_021035304.1|1273527_1274145_-|outer-membrane-lipoprotein-chaperone-LolA
MKKTTLKFAALTLLGLSNFALADAASELQMRLAKVDVLSAEFVQTVTSGSGKNIQQGSGKLQIKRPNLFRMETKTPQETQIISDGKTLWFYDPFVQQVTAQWVKDAVNNTPFVLLTSDDKTHWHQYTVTQQADTFVLKPTLSTSNIKQFDIRVDVNGILRNFSTTEKDGQTNLYVLRNITNQALSDSLFQFKPEKGVEVDDQRKK
>NC_022356.1|WP_021035303.1|1272126_1273467_-|replication-associated-recombination-protein-A
MSNLNFDFAENDFRPLAARMRPTSLEQYFGQSHLIGEGKPLRKAIQAGHIHSMILWGPPGTGKTTLAEIIAQRINAEVERISAVTSGIKEIREAIDRAKQNRLADRKTILFVDEVHRFNKSQQDAFLPHIEDGTVIFIGATTENPSFELNNALLSRARVYVLKSLTTAEIEQVLQQAVEDPKRGLGKERLILEENLLQVLAEYVNGDARLALNCLELMVDMADETENGKKIDRTLLKEVLGERQARFDKQGDRFYDLISALHKSVRGSAPDAALYWYARILTAGGDPLYVVRRLLAIASEDVGNADPRAMQVALAAWDCFTRVGAYEGERAIAQAIIYLAVAPKSNAVYTAFNTAKQQAKDLPDYDVPPHLRNAPTNLMKELGYGAEYRYAHDEPNAYAAGENYFPSELKDTQYYFPTNRGMEIQIKEKLERLREQDKSAVKKRYK
>NC_022356.1|WP_021035302.1|1270742_1272041_+|3-phosphoshikimate-1-carboxyvinyltransferase
MEKITLAPISAVEGTINLPGSKSLSNRALLLAALAKGTTKVTNLLDSDDIQHMLNALKALGVRYQLSDNKTICEIEGLGGTFNIQNNLSLFLGNAGTAMRPLTAALCLKGSTESEIILTGEPRMKERPILHLVDALRQAGADIRYLENDGYPPLAIRNKGIKGGKVKIDGSISSQFLTALLMSAPLAENDTEIEIIGELVSKPYIDITLAMMRDFGVQVENQHYQKFQVKGNQSYISPNKYLVEGDASSASYFLAAGAIKGKVKVTGIGKNSIQGDRLFADILEKMGAKITWGEDFIQAERAELNGIDMDMNHIPDAAMTIATTALFANGETVIRNIYNWRVKETDRLTAMATELRKVGAEVEEGEDFIRIQPLALNQFKHADIETYNDHRMAMCFSLIALSNTPVTILDPKCTAKTFPTFFSEFEKICLRD
>NC_022356.1|WP_021035301.1|1269906_1270743_+|formyltetrahydrofolate-deformylase
MIEKKILLTDCPDDKGLIAKITNICYKHQLNILHNNEFVDFETKHFFMRTELEGIFNEATLLEDLKYSLPEGTNCRLISTQRKRIVILVTKEAHCLGDILMKNYYGALDVEIAAVIGNHDNLRELVERFNIPFHLVSHENLTRVEHDKLLAKKIDEYTPDYIVLAKYMRVLNPEFVARYPNRVINIHHSFLPAFIGAKPYQQAYERGVKIIGATAHFINNELDQGPIIMQNVINVDHTYNAEAMMRAGRDVEKTVLSRALDLALHDRIFVYKNKTMVL
>NC_022356.1|WP_021035300.1|1269431_1269836_+|H-NS-histone-family-protein
MNELVRGLTNLRSLRAAVRELTLEQAENALEKLQTAIEEKRANEAELIKAETERKERLVKYKELMEKEGITPEELREIFGTTTVSTRAKRTPRPAKYAFIDENGEHKTWTGQGRTPRPIQNALNKGKSLSDFEI
>NC_022356.1|WP_021035299.1|1267460_1268981_-|Na+/H+-antiporter-NhaC-family-protein
MELIDFSSSVWSIVPALLAIILAIATRRVLVSLSAGIIIGSLMLSDWQIGSTFNYLVKNVVSLVYADGEINSNMNIVLFLLLLGVLTALLTVSGSNRAFAEWAQSRIKGRRGAKLLAASLVFVTFIDDYFHSLAVGAIARPVTDRFKVSRAKLAYILDSTAAPMCVMMPVSSWGAYIITLIGGLLATYSITEYTPIGAFVAMSSMNFYAIFSIIMVFFVAYFSFDIASMVRHEKLALENAEDQLEEETGAKGHVRNLILPILVLIIATVSMMIYTGAEALAADGKVFSVLGAFENTVVGTSLVVGGFCSIIISTLLTILDRQVSVPEYARSWIVGIKSMSGAIAILFFAWTINKIVGDMQTGKYLSSLVSGNIPMQFLPVILFVLGAAMAFSTGTSWGTFGIMLPIAAAMAANAAPELLLPCLSAVMAGAVCGDHCSPVSDTTILSSTGAKCNHIDHVTTQLPYAATVATATAIGYIVVGFTYSGLAGFVATAVSLIVIVFAVKKR
>NC_022356.1|WP_021035298.1|1265472_1267194_-|acetolactate-synthase-3-large-subunit
MKKLSGAEMVVQSLRDEGVEYVFGYPGGAVLDIYDAIHTLGGIEHILVRHEQAAVHMADGYARSTGKVGCVLVTSGPGATNAITGILTAYTDSVPMVIISGQVMSNLIGSDAFQECDMLGISRPVVKHSFIVKKAEDIPSTLKKAFYIASTGRPGPVVVDIPKDTVNPNFKYPYEYPESVELRSYNPTVNGHKGQIKKALKALLVAKKPILFVGGGAITAECSEQLIQFAQRLNLPVTSSLMGLGAYPSTDKQFLGMLGMHGTLEANTAMHESDLILGIGVRFDDRTTNNLEKYCPNAKVIHIDIDPTSISKNVPVAIPIVGNAKNILEEFLSLLNEEGLRSQTDLESWWQEINQWKAKKCLEFDRTSGVIKPQQVVEAVYRLTKGQAYVASDVGQHQMFAALHYPFDEPRHWINSGGAGTMGFGFPAALGVKLAHPEGTVVCVTGDGSIQMNIQELSTATQYGIPVVIICLNNHFLGMVKQWQDLIYSGRHSQTYMNSLPDFVKLAESYGHVGIKIATPDELESKLQEAFSIKNKLVFVDINVDESEHVYPMQIRGGAMNEMILSKPQEETN
>NC_022356.1|WP_021035307.1|1279066_1280113_-|inorganic-triphosphatase
MLQEIELKLAISPQIGIELPQYLAKFTILEHQNLFLGNTYYDYPDYFLAKQKMGLRIRQEDQELTLTLKTNGKVVGGLHSRSEYNLSLTEKETPTNAQLRELYPFEQLPRSTLQPIFFTDFNRTFWLVEFQQSKIEVAFDQGKIIAGESEQPICEIEFELKSGNVQDLFDFVETLPFERDIYFSSASKAKRGYLLGSKQFLTDWLNKWRDLLKEEREESVVDFCAKFNSVLKMEQKLLEETLSFSPALFSQDFMKTVERVGAFFNLYHYYDENGKILEAVATEKQKETLLPALLESNQKIFVEIRNLIRFHSETKDNEKTIEKLTALLKSRAYFERMIKLMELSYDLG
>NC_022356.1|WP_041175347.1|1280432_1281149_-|DUF2063-domain-containing-protein
MQPKSSLKETQQALANAIRLGNADPLNGYAASRLAVYTRLVRNNAFGFIDRCFVEAPLHIEPEYWKNAKENFVQNGNPHSPYFQDIAGEFLLFCQEKEIFDANILALMDFENTQLLAEVSLAKVPEKFEWDRHSVMQLSGAAYLKSYEVDFLSSDFKQFDDTPIQVIIWRDSDFRIQQQILSELDYWLLSYLQEQPNSLENVLSALNTMVEDSTSIIPLLEQVWMKWVTSEVIYPEQR
>NC_022356.1|WP_005647267.1|1281138_1282062_-|DUF692-family-protein
MKLQGAGLGYRRNLAEDFLQLPSNNAIQFIEVAPENWSKMGGMARYQFDQAAERFPLAVHGLSLSLGGQAPLDRELLRNTKALINQYNSSFFSEHLSYCECEGHLYDLLPMPFTEEAVKHVAQRIRDVQDFLGLQISLENTSYYLHSPTSTMNEVEFLNAIAQEADCGIHLDVNNIYVNGVNHGLLDPYIFLDQVDVKRVNYIHIAGHDEEHSAAQVVENSANESFNKVKGAYRHLPELLIDTHGEAVKGTVWDLLEYAYQRLPTIPPTLLERDFNFPPFAELYAEVEHIAQLQQKYAHTEVMSYAA
>NC_022356.1|WP_005671572.1|1282121_1282409_-|hypothetical-protein
MKKLATLTALAGALTMAVATAAQAESKSSNTDNTATPCVGDKCVKTKAAEGKCGEGKCGADKAKSAEGKCGEGKCGASKPKAAEGKCGEGKCGSK
>NC_022356.1|WP_005653243.1|1282447_1282888_-|DoxX-family-protein
MQGIGSGVSLLILRFFLAWEFFESGLEKWNGQNWFAEIQDRFPFPFNLIPADINWHVAMGSELIFPFLLIFGVLTRFSALSLTILISVAWYSIHADSGYNVCDNGYKLPLIYVVTLLILITQGAGKLSLDTLIKKVYPTKSWLKFL
>NC_022356.1|WP_005647270.1|1283110_1283791_+|TIGR00153-family-protein
MAMNNILGLFAHSPLKPLQKHSEKVTECSDLLIPFFQTTFSKNWEQAEEKRLEISQCEREADSLKREIRLKLPRGLFLPIDRTDLLELVTQQDKLANYAKDIAGRMIGRQFGIPEEMQEEFLHYVKRSLDAIHQAHRVIEEMDKLLETGFKGRELKLVNDMIQELDSIEDDTDQMQIKLRKMLYTIESRYNPIDVMFLYKIIEWVGVLADQAQRVGSRIELMLARS
>NC_022356.1|WP_021035309.1|1283815_1285078_+|inorganic-phosphate-transporter
MEIISQYGSWLVWITAAFGFFMAFGIGANDVSNSMGTSVGSGTVTAKQAIIIALIFESAGAYLAGGEVTQTIKSGVIDPMQFVDTPDILALGMLSTLFASGAWLFIATKMGWPVSGTHTIIGAIIGFACITIGPSSVDWSNIGSIVGSWFITPVISGILAYAIFASTQKLIFDTEQPLKNAQKYGPYYMGITMFVLCIVTMKKGLKHIGLNLSNSETLIISLVISLIGMLFFHFYFKSKTFTQSASKGTFGAVEKVFSILMLLTACAMAFAHGSNDVANAIGPLSAVVSIVNEGGKIASNSTLAWWILPLGALGIAVGLITMGQKVMATVGSGITDLTPSRGFAAQFATAMTVVVASGTGLPISTTQTLVGAILGIGFARGIAALNLTVIRNIISSWIVTLPAGAFFAIIIFYVLRTIFN
>NC_022356.1|WP_021035310.1|1285143_1285755_+|SH3-domain-containing-protein
MKKIYKALISSLLLSTSINVAYAETQYVTENLSTFLRRGAGEQFKIAGSIQAGEAVNVLDRQGKYTLIRDNKNREAWILNSDLSSTPSSKEENPKLKAQVQELTLKLSRLDGDWQQRTVEMQRRTKQAEQQSADLLEQNSQLKRELEMTKNKNRDLEAILDVGKREIAIQWFIYGGSVLGVGLLFGLLIPYVLPKRRRRDGWA
>NC_022356.1|WP_021035311.1|1285761_1287012_+|multifunctional-CCA-addition/repair-protein
MKIYLVGGAVRDQLLGLPVKDRDWILVGADPSTLLSLGYQQVGKDFPVFLNPKTKEEYALARTERKSSAGYTGFICDFSPTITLEQDLIRRDLTINAMAQSEDGEIIDPYDGKQDLENRILRHISPAFSEDPLRVLRVARFAARYHSLGFKIASETLSLMAELAQSGELQHLTAERVWLETEKALNEKNPEIYFETLHKTGALSVLFPEIDALYGVPNPVKHHPEVDSFIHTMLVLKQTVHLTENNHNLNKSAVRFAAICHDLGKALTPQNILPHHYGHEQAGIKPTRTLCKRLKVPSYFQELAELTCEFHTHIHKAFELRAETVITLFNRFDVWRKPQRFQEFLQVCLADTRGRTGFENKDYPQIDYINQLLQAANEVDVQQVIADGFEKQEIRNELTKRRILAVKQTKENYPKN
>NC_022356.1|WP_021035312.1|1287074_1287704_+|outer-membrane-lipoprotein-LolB
MNNMKTFKFLTALFATAILTACTLDMDRPTNVQYIDKTDAIWQQHLQQIQKIQSYQAKGQIGYISPTERFSSRFEWQYQNPKSYTLKLYSLISKSTLWIQMHQSGMTISDNNGNQQSADNAKLLLQEIIGMDVPLEHLAYWLKGEPAINADYQVGTNHLLGAFTYHVDGSQWTADYLTYHSNNSMPENILLKNDSTKQTLKIRVDEWIY

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

642646 : 722576

Haemophilus_phage(38.71%)

head,transposase,terminase,capsid,tail,tRNA,plate,protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_021034819.1\|642646_644005_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	NA	NA	NA	NA
WP_021034817.1\|644196_646065_+	SurA N-terminal domain-containing protein	NA	NA	NA	NA
WP_021034820.1\|646152_647712_+	phosphoethanolamine transferase	NA	NA	NA	NA
WP_021034821.1\|647781_648297_+	signal peptidase II	NA	NA	NA	NA
WP_021034822.1\|648293_649238_+	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	NA	NA	NA	NA
WP_021034824.1\|649405_649753_+	helix-hairpin-helix domain-containing protein	NA	NA	NA	NA
WP_021034825.1\|649999_650998_+	thiamine ABC transporter substrate binding subunit	NA	NA	NA	NA
WP_021034826.1\|651002_652619_+	thiamine/thiamine pyrophosphate ABC transporter, permease protein	NA	NA	NA	NA
WP_021034827.1\|652602_653250_+	thiamine ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	9.8e-23	36.2
WP_014550962.1\|653362_654364_+	biotin synthase BioB	NA	NA	NA	NA
WP_041175289.1\|654487_656485_-	transketolase	NA	NA	NA	NA
WP_021034830.1\|656864_657809_+	phosphoserine phosphatase	NA	NA	NA	NA
WP_005651674.1\|657826_658318_+	YajQ family cyclic di-GMP-binding protein	NA	NA	NA	NA
WP_021034831.1\|658613_659561_+	magnesium/cobalt transporter CorA	NA	NA	NA	NA
WP_021034832.1\|659560_660106_+	YggT family protein	NA	NA	NA	NA
WP_014550958.1\|660279_661116_-	class II glutamine amidotransferase	NA	NA	NA	NA
WP_041175290.1\|661542_662745_+	ATP-binding protein	NA	NA	NA	NA
WP_021034835.1\|663087_663990_-	RNA-directed DNA polymerase	Q7M2A9	Enterobacteria_phage	6.7e-30	32.1
WP_021034836.1\|663983_664943_-	hypothetical protein	NA	NA	NA	NA
WP_080228100.1\|665150_666386_-	meth protein	NA	NA	NA	NA
WP_005669790.1\|667123_667624_-	ferredoxin-type protein NapF	A0A077SLP0	Escherichia_phage	9.2e-13	31.4
WP_005669792.1\|667623_668235_-	Tat proofreading chaperone DmsD	A0A077SLS7	Escherichia_phage	3.0e-21	32.5
WP_041175291.1\|668346_669186_-	dimethyl sulfoxide reductase anchor subunit	A0A077SK59	Escherichia_phage	2.9e-19	33.2
WP_005669796.1\|669187_669805_-	dimethylsulfoxide reductase subunit B	A0A077SL61	Escherichia_phage	2.2e-72	57.3
WP_021034840.1\|669815_672236_-	molybdopterin-dependent oxidoreductase	A0A077SK27	Escherichia_phage	2.4e-223	50.4
WP_021034841.1\|672488_673598_+	transglutaminase family protein	NA	NA	NA	NA
WP_021034842.1\|673572_673935_+	MerT	NA	NA	NA	NA
WP_021034843.1\|673943_674222_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_021034845.1\|675015_675669_-	capsule polysaccharide exporter ATP-binding protein BexA	M1HXU1	Acanthocystis_turfacea_Chlorella_virus	9.3e-05	25.6
WP_021034846.1\|675665_676463_-	capsule polysaccharide exporter permease BexB	NA	NA	NA	NA
WP_021034847.1\|676462_677596_-	capsule polysaccharide exporter BexC	NA	NA	NA	NA
WP_021034848.1\|677610_678795_-	capsule polysaccharide exporter BexD	NA	NA	NA	NA
WP_021034849.1\|679156_680251_+	Stealth CR1 domain-containing protein	NA	NA	NA	NA
WP_021034850.1\|680259_682923_+	bifunctional glycosyltransferase family 2 protein/CDP-glycerol:glycerophosphate glycerophosphotransferase	NA	NA	NA	NA
WP_021034851.1\|682915_684055_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_021034852.1\|684124_686167_+	capsular polysaccharide biosynthesis protein	NA	NA	NA	NA
WP_021034853.1\|686220_687441_+	capsule polysaccharide modification protein HcsB	NA	NA	NA	NA
WP_021034855.1\|690565_691531_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_021034856.1\|691520_692408_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_041175397.1\|694053_694470_-\|transposase	IS200/IS605 family transposase	A0A1S5RHE3	Helicobacter_phage	4.2e-51	66.4
WP_041175292.1\|694515_695652_+\|transposase	transposase	A0A1B0VCD8	Salmonella_phage	1.6e-121	56.7
WP_021034860.1\|696449_696668_-	hypothetical protein	NA	NA	NA	NA
WP_005641687.1\|697639_697759_-	Com family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_021034863.1\|699052_700126_-	hypothetical protein	H6W7W2	Escherichia_phage	2.5e-07	30.9
WP_172454002.1\|701037_701634_-	DUF2313 domain-containing protein	F6MIL7	Haemophilus_phage	2.3e-66	63.0
WP_021034866.1\|701630_702695_-\|plate	baseplate J/gp47 family protein	F6MIL6	Haemophilus_phage	9.8e-129	66.9
WP_041175293.1\|702709_703060_-	phage GP46 family protein	A0A0M3LQK5	Mannheimia_phage	1.2e-43	73.3
WP_021034868.1\|703129_703765_-\|plate	phage baseplate assembly protein V	A0A0M3LPA3	Mannheimia_phage	4.7e-62	58.3
WP_021034869.1\|703774_704899_-	bacteriophage Mu P family protein	F6MIL3	Haemophilus_phage	1.4e-146	72.7
WP_021034870.1\|704888_706223_-	DNA circularization N-terminal domain-containing protein	F6MIL2	Haemophilus_phage	6.3e-109	45.6
WP_021034873.1\|708550_708757_-	hypothetical protein	NA	NA	NA	NA
WP_021034874.1\|708771_709113_-	hypothetical protein	A0A0M3LSI2	Mannheimia_phage	1.8e-20	50.5
WP_021034875.1\|709112_709484_-	hypothetical protein	A0A0M3LRV6	Mannheimia_phage	1.2e-36	65.0
WP_021034876.1\|709493_710909_-\|tail	phage tail sheath subtilisin-like domain-containing protein	B7SDP8	Haemophilus_phage	1.1e-156	62.6
WP_041175294.1\|710901_711084_-	DUF2635 domain-containing protein	A0A0M3LQM9	Mannheimia_phage	1.0e-09	63.3
WP_021034878.1\|711055_711718_-	DUF1834 family protein	A0A0M3LQJ7	Mannheimia_phage	1.2e-44	45.0
WP_021034879.1\|711701_712133_-	DUF1320 domain-containing protein	B7SDP4	Haemophilus_phage	1.3e-36	60.9
WP_021034880.1\|712142_712448_-	hypothetical protein	B7SDP3	Haemophilus_phage	6.9e-19	47.0
WP_021034881.1\|712511_713435_-\|head	Mu-like prophage major head subunit gpT family protein	B7SDP1	Haemophilus_phage	1.4e-134	75.2
WP_021034882.1\|713434_714472_-\|protease	phage protease	B7SDN9	Haemophilus_phage	7.2e-68	46.7
WP_021034883.1\|714754_715171_-	phage virion morphogenesis protein	B7SDN8	Haemophilus_phage	2.1e-47	66.7
WP_021034884.1\|715293_716601_-\|capsid	minor capsid protein	A0A0M3LSH7	Mannheimia_phage	3.1e-161	67.4
WP_021034885.1\|716584_718207_-	DUF935 domain-containing protein	B7SDN1	Haemophilus_phage	7.0e-203	68.3
WP_021034886.1\|718287_719928_-\|terminase	phage terminase large subunit	B7SDN0	Haemophilus_phage	9.4e-248	77.8
WP_005651690.1\|720375_720654_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_021034888.1\|720731_722576_-	ABC transporter ATP-binding protein	F2Y2R6	Organic_Lake_phycodnavirus	4.8e-22	29.3

DBSCAN-SWA_2

1327119 : 1386308

Mannheimia_phage(30.77%)

head,capsid,holin,tail,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_021035348.1\|1327119_1327929_-\|tRNA	tRNA pseudouridine(38-40) synthase TruA	NA	NA	NA	NA
WP_012054441.1\|1328163_1329165_+	class 1 fructose-bisphosphatase	A0A1V0SKX4	Klosneuvirus	4.6e-72	43.9
WP_021035350.1\|1329901_1331350_-\|protease	metalloprotease TldD	NA	NA	NA	NA
WP_021035351.1\|1331451_1332303_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	6.1e-49	45.0
WP_021035352.1\|1332374_1334102_+	penicillin-binding protein activator	NA	NA	NA	NA
WP_021035353.1\|1334101_1334461_+	YraN family protein	NA	NA	NA	NA
WP_021035354.1\|1334473_1335058_+	SIS domain-containing protein	NA	NA	NA	NA
WP_021035355.1\|1335114_1335696_+	divisome-associated lipoprotein YraP	NA	NA	NA	NA
WP_041175349.1\|1335950_1338221_+	ribonucleoside-diphosphate reductase subunit alpha	I3UMG3	Colwellia_phage	3.7e-303	67.5
WP_005650087.1\|1338363_1339494_+	ribonucleotide-diphosphate reductase subunit beta	G9IAA3	Pseudomonas_phage	1.6e-169	78.6
WP_021035357.1\|1339608_1340838_-	2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase	NA	NA	NA	NA
WP_041175350.1\|1340944_1343752_-	2-oxoglutarate dehydrogenase E1 component	NA	NA	NA	NA
WP_021035359.1\|1343948_1345034_-	YadA-like family protein	NA	NA	NA	NA
WP_021035361.1\|1345407_1346076_-	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_021035362.1\|1346085_1346841_-	TatD family hydrolase	NA	NA	NA	NA
WP_021035363.1\|1346892_1347453_-	YcbK family protein	NA	NA	NA	NA
WP_041175351.1\|1347467_1348937_-	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_021035365.1\|1348997_1351079_-	carboxy terminal-processing peptidase	A0A0R6PIZ1	Moraxella_phage	9.9e-85	32.8
WP_021035366.1\|1351106_1351745_-	RNA chaperone ProQ	NA	NA	NA	NA
WP_021035367.1\|1351928_1353179_+	paraquat-inducible protein A	NA	NA	NA	NA
WP_021035368.1\|1353162_1355808_+	PqiB family protein	NA	NA	NA	NA
WP_021035369.1\|1355862_1356315_-	molybdopterin synthase catalytic subunit MoaE	NA	NA	NA	NA
WP_021035370.1\|1356315_1356561_-	molybdopterin synthase sulfur carrier subunit	NA	NA	NA	NA
WP_005650053.1\|1356562_1357045_-	cyclic pyranopterin monophosphate synthase MoaC	NA	NA	NA	NA
WP_021035371.1\|1357136_1358150_-	GTP 3',8-cyclase MoaA	D5GVS6	Campylobacter_virus	4.5e-06	31.5
WP_021035372.1\|1358595_1359267_+	iron-sulfur cluster repair protein YtfE	NA	NA	NA	NA
WP_005665006.1\|1359879_1360815_+	KpsF/GutQ family sugar isomerase	A0A2P0VNK5	Tetraselmis_virus	6.1e-42	35.2
WP_012054717.1\|1360824_1361367_+	HAD family hydrolase	A0A140XBD6	Dickeya_phage	6.3e-23	44.2
WP_021035373.1\|1361484_1363620_-	TIGR01666 family membrane protein	NA	NA	NA	NA
WP_021035374.1\|1363687_1364353_-	DUF2057 domain-containing protein	NA	NA	NA	NA
WP_021035375.1\|1364552_1365614_+\|protease	protease SohB	A0A2H4UUF9	Bodo_saltans_virus	7.4e-20	31.7
WP_005631902.1\|1365897_1366476_+	electron transport complex subunit RsxA	NA	NA	NA	NA
WP_021035376.1\|1366563_1367145_+	electron transport complex subunit RsxB	NA	NA	NA	NA
WP_005631902.1\|1371688_1372267_+	electron transport complex subunit RsxA	NA	NA	NA	NA
WP_005631904.1\|1372354_1372936_+	electron transport complex subunit RsxB	NA	NA	NA	NA
WP_021035380.1\|1372936_1375018_+	electron transport complex subunit RsxC	NA	NA	NA	NA
WP_041175353.1\|1375380_1376457_+	electron transport complex subunit RsxD	NA	NA	NA	NA
WP_021035383.1\|1376456_1377080_+	electron transport complex subunit RsxG	NA	NA	NA	NA
WP_021035384.1\|1377081_1377789_+	electron transport complex subunit E	NA	NA	NA	NA
WP_021035385.1\|1377968_1378604_+	endonuclease III	NA	NA	NA	NA
WP_041175354.1\|1378662_1380036_+	sodium-dependent transporter	NA	NA	NA	NA
WP_041175355.1\|1382911_1383175_-	hypothetical protein	NA	NA	NA	NA
WP_021035389.1\|1383419_1383938_-	lysozyme	A0A0M3LPQ1	Mannheimia_phage	1.5e-37	47.7
WP_005689816.1\|1383930_1384152_-\|holin	phage holin family protein	NA	NA	NA	NA
WP_021035391.1\|1384153_1384363_-\|tail	tail protein X	A0A0M3LPY0	Mannheimia_phage	1.0e-10	43.8
WP_021035392.1\|1384362_1384869_-\|head	head completion/stabilization protein	A0A0M3LNL8	Mannheimia_phage	1.4e-32	50.7
WP_021035395.1\|1385501_1386308_-\|capsid	GPO family capsid scaffolding protein	A0A0M3LNM2	Mannheimia_phage	3.3e-60	58.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022356

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection