CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022516	Streptococcus suis YB51, complete sequence	3 crisprs	DinG,csn2,cas2,cas1,cas9,csa3,cas3,DEDDh	2	9	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022516_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022516_1

74577-74651

Orphan

Consensus_repeat	Method
AAAACAAGAAAGTGAATTAAGGTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022516_1

>merge|NC_022516|1|74577-74651|CRISPRCasFinder
AAAACAAGAAAGTGAATTAAGGTCCAGTGGACCTTTTTGTCATGAGCCTGAAAACAAGAAAGCGAATTAAGGTCC

>NC_022516|1|1|74577-74651|CRISPRCasFinder
AAAACAAGAAAGTGAATTAAGGTCC	AGTGGACCTTTTTGTCATGAGCCTG
AAAACAAGAAAGCGAATTAAGGTCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022516.1\|WP_002936661.1\|79692_80346_+\|30S-ribosomal-protein-S3	unknown	unknown	gnl\|CDD\|234722
NC_022516.1\|WP_002939360.1\|72052_72319_+\|IreB-family-regulatory-phosphoprotein	unknown	unknown	gnl\|CDD\|180108
NC_022516.1\|WP_004195490.1\|77161_77785_+\|50S-ribosomal-protein-L4	unknown	unknown	gnl\|CDD\|235404
NC_022516.1\|WP_004194473.1\|65508_67446_+\|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl\|CDD\|234630
NC_022516.1\|WP_002936663.1\|78101_78935_+\|50S-ribosomal-protein-L2	unknown	unknown	gnl\|CDD\|236488
NC_022516.1\|WP_011922545.1\|70167_71319_+\|recombinase-RecA	unknown	unknown	gnl\|CDD\|236476
NC_022516.1\|WP_002939356.1\|72318_72738_+\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|234639
NC_022516.1\|WP_004195491.1\|77784_78084_+\|50S-ribosomal-protein-L23	unknown	unknown	gnl\|CDD\|235586
NC_022516.1\|WP_004194470.1\|67484_68075_+\|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl\|CDD\|234645
NC_022516.1\|WP_004194467.1\|68934_70116_+\|competence/damage-inducible-protein-A	unknown	unknown	gnl\|CDD\|234789
NC_022516.1\|WP_002936184.1\|73195_74452_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|225995
NC_022516.1\|WP_004194469.1\|68328_68898_+\|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl\|CDD\|377025
NC_022516.1\|WP_002939362.1\|71554_71953_+\|transcriptional-regulator-Spx	unknown	unknown	gnl\|CDD\|183988
NC_022516.1\|WP_013730061.1\|75989_76298_+\|30S-ribosomal-protein-S10	unknown	unknown	gnl\|CDD\|179076
NC_022516.1\|WP_002936660.1\|80349_80763_+\|50S-ribosomal-protein-L16	unknown	unknown	gnl\|CDD\|236411
NC_022516.1\|WP_002939343.1\|72749_73070_+\|DUF1292-domain-containing-protein	unknown	unknown	gnl\|CDD\|184235
NC_022516.1\|WP_011921686.1\|76510_77137_+\|50S-ribosomal-protein-L3	unknown	unknown	gnl\|CDD\|234564
NC_022516.1\|WP_000533766.1\|79036_79318_+\|30S-ribosomal-protein-S19	unknown	unknown	gnl\|CDD\|178985
NC_022516.1\|WP_002939335.1\|75401_75668_+\|hypothetical-protein	unknown	unknown	unknown
NC_022516.1\|WP_002936662.1\|79335_79680_+\|50S-ribosomal-protein-L22	unknown	unknown	gnl\|CDD\|234793

Protein	Function_ID	Function_description	E-value
NC_022516.1\|WP_002936661.1\|79692_80346_+\|30S-ribosomal-protein-S3	gnl\|CDD\|234722	PRK00310, rpsC, 30S ribosomal protein S3; Reviewed.	3.51793e-146
NC_022516.1\|WP_002939360.1\|72052_72319_+\|IreB-family-regulatory-phosphoprotein	gnl\|CDD\|180108	PRK05473, IreB-like, IreB family regulatory phosphoprotein. IreB (EF1202) was characterized in Enterococcus faecalis as a small protein, well-conserved in the Firmicutes. It belongs to a system that includes the Ser/Thr protein kinase IreK, and phosphatase IreP, undergoes phosphorylation on threonine residues, and is involved in regulating cephalosporin resistance. This family was previously named DUF965 by Pfam model pfam06135.	2.53526e-51
NC_022516.1\|WP_004195490.1\|77161_77785_+\|50S-ribosomal-protein-L4	gnl\|CDD\|235404	PRK05319, rplD, 50S ribosomal protein L4; Provisional.	2.52886e-114
NC_022516.1\|WP_004194473.1\|65508_67446_+\|DNA-mismatch-repair-endonuclease-MutL	gnl\|CDD\|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	0
NC_022516.1\|WP_002936663.1\|78101_78935_+\|50S-ribosomal-protein-L2	gnl\|CDD\|236488	PRK09374, rplB, 50S ribosomal protein L2; Validated.	0
NC_022516.1\|WP_011922545.1\|70167_71319_+\|recombinase-RecA	gnl\|CDD\|236476	PRK09354, recA, recombinase A; Provisional.	0
NC_022516.1\|WP_002939356.1\|72318_72738_+\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|234639	PRK00109, PRK00109, Holliday junction resolvase RuvX.	2.01401e-63
NC_022516.1\|WP_004195491.1\|77784_78084_+\|50S-ribosomal-protein-L23	gnl\|CDD\|235586	PRK05738, rplW, 50S ribosomal protein L23; Reviewed.	3.64374e-36
NC_022516.1\|WP_004194470.1\|67484_68075_+\|Holliday-junction-branch-migration-protein-RuvA	gnl\|CDD\|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	1.86173e-83
NC_022516.1\|WP_004194467.1\|68934_70116_+\|competence/damage-inducible-protein-A	gnl\|CDD\|234789	PRK00549, PRK00549, competence damage-inducible protein A; Provisional.	0
NC_022516.1\|WP_002936184.1\|73195_74452_-\|ISL3-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.18781e-111
NC_022516.1\|WP_004194469.1\|68328_68898_+\|DNA-3-methyladenine-glycosylase-I	gnl\|CDD\|377025	pfam03352, Adenine_glyco, Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.	1.28285e-109
NC_022516.1\|WP_002939362.1\|71554_71953_+\|transcriptional-regulator-Spx	gnl\|CDD\|183988	PRK13344, spxA, transcriptional regulator Spx; Reviewed.	4.09612e-82
NC_022516.1\|WP_013730061.1\|75989_76298_+\|30S-ribosomal-protein-S10	gnl\|CDD\|179076	PRK00596, rpsJ, 30S ribosomal protein S10; Reviewed.	2.68913e-65
NC_022516.1\|WP_002936660.1\|80349_80763_+\|50S-ribosomal-protein-L16	gnl\|CDD\|236411	PRK09203, rplP, 50S ribosomal protein L16; Reviewed.	8.67715e-89
NC_022516.1\|WP_002939343.1\|72749_73070_+\|DUF1292-domain-containing-protein	gnl\|CDD\|184235	PRK13678, PRK13678, hypothetical protein; Provisional.	3.05006e-29
NC_022516.1\|WP_011921686.1\|76510_77137_+\|50S-ribosomal-protein-L3	gnl\|CDD\|234564	PRK00001, rplC, 50S ribosomal protein L3; Validated.	7.59011e-127
NC_022516.1\|WP_000533766.1\|79036_79318_+\|30S-ribosomal-protein-S19	gnl\|CDD\|178985	PRK00357, rpsS, 30S ribosomal protein S19; Reviewed.	3.00826e-63
NC_022516.1\|WP_002936662.1\|79335_79680_+\|50S-ribosomal-protein-L22	gnl\|CDD\|234793	PRK00565, rplV, 50S ribosomal protein L22; Reviewed.	2.08492e-62

>NC_022516.1|WP_002936184.1|73195_74452_-|ISL3-family-transposase
MEQLNLITNFLRIKDKNIVITDEYDMGTHLELHGHLDYTAPKCPSCKGQMTKYDFQKASKIPYLETAGYPLLIRLRKRRFKCKDCGKIAVAETPLVKKNHQISVAVNQKIAQLLIENQAMTHIAHRLSISTSSVMRKLNEFKFETDWNTLPEVMSWDEYSFKKGKMSFIAQDFNSLNVITILDGRTQATIRNHFLRYPRKVRNQVKVITMDMFSPYYQLAKQLFPNAKIVLDRFHIVQHLSRAMNRIRIQIMNQFDRTSQEYRALKRYWKLIQQDSRKLSDKRFYRPMFRMHLTNKEILEKLLSFSEELRQHYELYQLLLFHFQEKNSDHFFDIVELEIATVNPIFQTVFKTFLKDKDKVLNALELPYSNAKLEATNNLIKVIKRNAFGFRNFENFKKRILIALNIKKERTKFVLSRC
>NC_022516.1|WP_002939343.1|72749_73070_+|DUF1292-domain-containing-protein
MAHHHDHEHDHNHDERELITLVDDQGNETLFEILLTIDGQEEFGKNYVLLIPASAEEDENGEVEIQAYSYIENENGTEGDLQPIPEDATAEWDMIEEVFNSFMEEE
>NC_022516.1|WP_002939356.1|72318_72738_+|Holliday-junction-resolvase-RuvX
MRIMGLDVGSKTVGVAISDPLGFTAQGLEIIPIDEEKGEFGLERLTELVEQYKVDKFVVGLPKNMNNTSGPRVEASQAYGDLLTERYKLPVDYQDERLTTVAAERMLIEQADISRGKRKKVIDKLAAQLILQNYLDRTF
>NC_022516.1|WP_002939360.1|72052_72319_+|IreB-family-regulatory-phosphoprotein
MGFTEETVRFRLDDTDKQEISKTLTSVYRSLEEKGYNPINQIIGYVLSGDPAYIPRYNDARNQIRKHERDEIIEELVRYYLKGNGIDL
>NC_022516.1|WP_002939362.1|71554_71953_+|transcriptional-regulator-Spx
MIKIYTVSSCTSCKKAKNWLNAHQLSYNEHNLAKEAITKEEILNILTKTENGIASIVSSKNRYAKSLDFDIEELSVNEVIDLITSNPRILKSPILIDEKRLQVGYKEDDIRAFLPRAVRNVENAQARMRAAL
>NC_022516.1|WP_011922545.1|70167_71319_+|recombinase-RecA
MAKKPGKKLEDITKKFGDERKKALDDALKSIEKDFGKGAVMRLGERAEQKVQVMSSGSLSIDIALGAGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKDGGIAAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALVPRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTVAIFINQLREKVGVMFGNPETTPGGRALKFYASVRMDVRGNTQIKGTGDKKDQNVGKETKVKIVKNKVAPPFKEAVVEIMYGEGISRTGELIEIGSNLGIIQKAGAWYSYNGEKIGQGSENAKKFLADNPAIFDEIDRKIRVHYGLIEADGVEEVATEEAPVVAEEIQDVILDLDGGIELED
>NC_022516.1|WP_004194467.1|68934_70116_+|competence/damage-inducible-protein-A
MKAELIAVGTEILTGQIVNTNAQFLSEKCAELGIDVYFHTAVGDNEQRLLSVLEVARQRSDLVILCGGLGPTEDDLTKQILATFLGRNLVFDELAMAKLDRFFASRPGRVRTPNNERQAQIVEGSQALQNPAGLAVGGMIEQDGVTYIVLPGPPSELKAMFSESLLPLLSQSQQQLYSRILRFFGIGESQLVTVLADLIDKQTDPTLAPYAKVGEVTLRLSTKATSQEEANLRLNQLEEEILQHDKLADYFYAYGEDNSLVKTVATRLAEKRQTIAIVEQGTGGLLQAELSLALADQPYFSGGKVIGQLGTESGRLSEEADCIRQELQADLGLAVSVLIKPESTEDNVLAKVYLTLATTSGISQKEIDLGGYSWQYLRQLACLQAWDFVRNTL
>NC_022516.1|WP_004194469.1|68328_68898_+|DNA-3-methyladenine-glycosylase-I
MSRCAWVNLNNPLYIAYHDEEWGKSLHDEQSLFELLCLESYQAGLSWEIVLNKRQAFRSAFFNYDIQKVAAMTDSELDSLLTNPDIIRHKAKLYATRANAQAFLRVQEEFGTFDTYLWSWVDFTPLDNPIKSFRELPTKSELSERLSKDLKKRGFKFVGPVCIYSYLQAAGLLNEHEETCEIGKKLRTN
>NC_022516.1|WP_004194470.1|67484_68075_+|Holliday-junction-branch-migration-protein-RuvA
MYDYIKGILTKITAKYIVVETQGVGYILQVANPYAYSGQVQQEVTVYTHQVIREDAHLLYGFATENEKSVFLSLISVSGIGPTTALAIIAVDDNDGLVRAIEQKNITYLTKFPKIGKKTAQQMILDLEGKFVMSEEAGPVQQVAPSSENIALDEAMEAMEALGYRPAELKKIKKFFEGTNDTAENYIKSALKMLMK
>NC_022516.1|WP_004194473.1|65508_67446_+|DNA-mismatch-repair-endonuclease-MutL
MSHIIELPEILANQIAAGEVIERPASVVKELVENSIDAGASQIEISVEEAGLKMIQITDNGEGIAPDEVALALRRHATSKIKNQSDLFRIRTLGFRGEALPSIASVSHMIIETATADSAHGLHLEAKGGVIEKEEPVSRPVGTQITVSDLFYNTPARLKYVRSQQAELSHIVDVVNRLSLAHPEMAFALVNEGRELIRTAGTGKLRQAISGIYGIASAKKMVEIEAEDLDFQISGYVSLPELTRANRNYISIFINGRYIKNFLLNRAILEGYGSKLMVGRFPLAVISIEIDPYLADVNVHPTKQEVRISKEKELMTLIREAISQALKEQDLIPDALENLAQSSTRPKVKAEQGTLPLREPKIYYDTIKQDFFLKPDVVAEDVKPLEEDRQEIVESPAENKPTSVQFAERQSVESEDQEHPNLSAKELAKLADKLDREATSTFPELEYFGQMHGTYLFAQGKTGLYIIDQHAAQERVKYEYYREKIGQVDNSAQQLLVPYIFEFPQNDALDLVHKMDALRQVGVNLEEYGSNQFILREHPIWMKEEEIESGIYEMCDMLLLTDQVSIKQYRAELAIMMSCKRSIKANHALDDYSARDLLRQLSYCQNPYNCPHGRPVLVHFSKSDMEKMFRRIQENHTSLRELGKY
>NC_022516.1|WP_002939335.1|75401_75668_+|hypothetical-protein
MEFETVCLKVRNLGRLYCYFKVKFRNHIEAIIRKQESQKCKFDRLFHEDIHSLIQSPSLGNDELLMLWGLLRDYRKNLINDRLENMKN
>NC_022516.1|WP_013730061.1|75989_76298_+|30S-ribosomal-protein-S10
MANKKIRIRLKAYEHRTLDTAAAKIVETATRTGAQVAGPVPLPTERSLYTIIRATHKYKDSREQFEMRTHKRLIDIINPTQKTVDALMKLALPSGVNVEIKL
>NC_022516.1|WP_011921686.1|76510_77137_+|50S-ribosomal-protein-L3
MTKGILGKKVGMTQIFTESGEFIPVTVIEATPNVVLQVKTVETDGYAAVQVGFDDKREVLSNKPAKGHVAKANTAPKRFIREFKNIEGLEVGQEITVETFAAGDVVDVTGTSKGKGFQGVIKRHGQSRGPMAHGSRYHRRPGSMGPVAPNRVFKGKNLAGRMGGNRVTIQNLEVVQVVPEKNVILIKGNVPGAKKSLITIKSAVKAGK
>NC_022516.1|WP_004195490.1|77161_77785_+|50S-ribosomal-protein-L4
MANVTLFDQTGKQAGEVVLNDAIFGIEPNQAVVFDVIISQRASLRQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYAYKLPQKVRRLALKSVYSEKVAENKFVAVNSLEFTAPKTAEFAKVLAALSIDSKVLVILEEGNEFAALSARNIPGVKVATATTASVLDIANADKLLVTQAAISKIEEVLA
>NC_022516.1|WP_004195491.1|77784_78084_+|50S-ribosomal-protein-L23
MNLYDVIKKPVITESSMGQLEAGKYVFEVDTRAHKLLIKQAVEAAFEGVKVANVNTINVKPKTKRVGRYVGRTNKVKKAIITLAADSKAIELFATADAE
>NC_022516.1|WP_002936663.1|78101_78935_+|50S-ribosomal-protein-L2
MGIKVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVALKSKAGRNNNGRITVRHQGGGHKRFYRLVDFKRNKDGVEAIVKTIEYDPNRSANIALVHYTDGVKAYIIAPKGLEVGQRIVSGPEADIKVGNALPLANIPVGTVVHNIELKPGRGGELVRAAGASAQVLGQEGKYVLVRLQSGEVRMILGTCRATVGTVGNEQHGLVNLGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNQK
>NC_022516.1|WP_000533766.1|79036_79318_+|30S-ribosomal-protein-S19
MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSFIGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRRK
>NC_022516.1|WP_002936662.1|79335_79680_+|50S-ribosomal-protein-L22
MAEITSAKATARTVRVSPRKSRLVLDNIRGKSVADAIAILKFTPNKAAGIIEGVLNSAIANAENNFGLEKANLVVSEAFANEGPTLKRFRPRAKGSASPINKRTAHITVVVAEK
>NC_022516.1|WP_002936661.1|79692_80346_+|30S-ribosomal-protein-S3
MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRNFIKKELADASTSTIEIERAVNKVIVSIHTAKPGMVIGKAGSNVDALRAQLNKLTGKQVHINIIEIKQPDLDAHLVGESIARQLEQRVAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGADIARAEGYSEGTVPLHTLRADIDYAWEEALTTYGKLGVKVWIYRGEVLPARKNTKGGK
>NC_022516.1|WP_002936660.1|80349_80763_+|50S-ribosomal-protein-L16
MLVPKRVKHRREFRGKMRGEAKGGKQVDFGQYGLQATTSSWITNRQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKVMFEVAGVSEEIAREAFRLAGHKLPVKVKFVKREAE

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Crispr_ID: NC_022516_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022516_2

1104712-1104795

Orphan

Consensus_repeat	Method
GGAGGTTGGAAATTGAGCGAACGAAGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022516_2

>merge|NC_022516|2|1104712-1104795|CRISPRCasFinder
GGAGGTTGGAAATTGAGCGAACGAAGTTCATTTCTACAAAGGTTTGGGGAAACTTGGGAGGTTGGAAATAGAGCGAACGAAGTT

>NC_022516|2|2|1104712-1104795|CRISPRCasFinder
GGAGGTTGGAAATTGAGCGAACGAAGTT	CATTTCTACAAAGGTTTGGGGAAACTTG
GGAGGTTGGAAATAGAGCGAACGAAGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022516.1\|WP_002935240.1\|1109680_1110574_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NC_022516.1\|WP_002935239.1\|1108688_1109663_-\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|236609
NC_022516.1\|WP_002935234.1\|1100564_1101365_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225484
NC_022516.1\|WP_013730387.1\|1112844_1113822_+\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|235039
NC_022516.1\|WP_002935232.1\|1099400_1099943_-\|hypothetical-protein	unknown	unknown	unknown
NC_022516.1\|WP_002935225.1\|1095345_1095768_-\|galactose-6-phosphate-isomerase-subunit-LacA	unknown	unknown	gnl\|CDD\|181505
NC_022516.1\|WP_002935224.1\|1094803_1095319_-\|galactose-6-phosphate-isomerase-subunit-LacB	unknown	unknown	gnl\|CDD\|181506
NC_022516.1\|WP_009909915.1\|1097019_1097775_+\|hypothetical-protein	unknown	unknown	unknown
NC_022516.1\|WP_002935247.1\|1113832_1114948_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_022516.1\|WP_013730386.1\|1103450_1104611_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NC_022516.1\|WP_002935238.1\|1106950_1108687_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_022516.1\|WP_032497578.1\|1110573_1111401_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|235317
NC_022516.1\|WP_002935226.1\|1095973_1096741_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NC_022516.1\|WP_002935237.1\|1105221_1106964_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_022516.1\|WP_002935233.1\|1099962_1100433_-\|hypothetical-protein	unknown	unknown	unknown
NC_022516.1\|WP_002935242.1\|1111375_1112047_-\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NC_022516.1\|WP_002936184.1\|1101637_1102894_+\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|225995
NC_022516.1\|WP_002935231.1\|1098143_1099175_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271189
NC_022516.1\|WP_002935243.1\|1112133_1112700_+\|CYTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|143627
NC_022516.1\|WP_029694144.1\|1104845_1105238_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|224961

Protein	Function_ID	Function_description	E-value
NC_022516.1\|WP_002935240.1\|1109680_1110574_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	7.61445e-90
NC_022516.1\|WP_002935239.1\|1108688_1109663_-\|phosphate-acetyltransferase	gnl\|CDD\|236609	PRK09653, eutD, phosphotransacetylase.	0
NC_022516.1\|WP_002935234.1\|1100564_1101365_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225484	COG2932, COG2932, Predicted transcriptional regulator [Transcription].	2.87242e-15
NC_022516.1\|WP_013730387.1\|1112844_1113822_+\|ribose-phosphate-diphosphokinase	gnl\|CDD\|235039	PRK02458, PRK02458, ribose-phosphate pyrophosphokinase; Provisional.	0
NC_022516.1\|WP_002935225.1\|1095345_1095768_-\|galactose-6-phosphate-isomerase-subunit-LacA	gnl\|CDD\|181505	PRK08621, PRK08621, galactose-6-phosphate isomerase subunit LacA; Reviewed.	6.97048e-84
NC_022516.1\|WP_032497578.1\|1110573_1111401_-\|NAD-kinase	gnl\|CDD\|235317	PRK04885, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	1.85355e-172
NC_022516.1\|WP_013730386.1\|1103450_1104611_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	1.46415e-147
NC_022516.1\|WP_002935238.1\|1106950_1108687_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.29037e-130
NC_022516.1\|WP_002935247.1\|1113832_1114948_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	3.30339e-174
NC_022516.1\|WP_002935226.1\|1095973_1096741_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.73173e-82
NC_022516.1\|WP_029694144.1\|1104845_1105238_-\|PaaI-family-thioesterase	gnl\|CDD\|224961	COG2050, PaaI, HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism].	5.94332e-25
NC_022516.1\|WP_002935224.1\|1094803_1095319_-\|galactose-6-phosphate-isomerase-subunit-LacB	gnl\|CDD\|181506	PRK08622, PRK08622, galactose-6-phosphate isomerase subunit LacB; Reviewed.	8.87204e-126
NC_022516.1\|WP_002935242.1\|1111375_1112047_-\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	5.5421e-94
NC_022516.1\|WP_002936184.1\|1101637_1102894_+\|ISL3-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.18781e-111
NC_022516.1\|WP_002935231.1\|1098143_1099175_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.90416e-22
NC_022516.1\|WP_002935243.1\|1112133_1112700_+\|CYTH-domain-containing-protein	gnl\|CDD\|143627	cd07762, CYTH-like_Pase_1, Uncharacterized subgroup 1 of the CYTH-like superfamily. Enzymes belonging to the CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) superfamily hydrolyze triphosphate-containing substrates, require metal cations as cofactors, and have a unique active site located at the center of an eight-stranded antiparallel beta barrel tunnel (the triphosphate tunnel). The name CYTH originated from the gene designation for bacterial class IV adenylyl cyclases (CyaB) and from thiamine triphosphatase. Class IV adenylate cyclases catalyze the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. Thiamine triphosphatase is a soluble cytosolic enzyme which converts thiamine triphosphate to thiamine diphosphate. This domain superfamily also contains RNA triphosphatases, membrane-associated polyphosphate polymerases, tripolyphosphatases, nucleoside triphosphatases, nucleoside tetraphosphatases and other proteins with unknown functions. Proteins of this subgroup are of bacterial origin and have not been characterized.	3.30094e-69
NC_022516.1\|WP_002935237.1\|1105221_1106964_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	5.43285e-169

>NC_022516.1|WP_013730386.1|1103450_1104611_-|A/G-specific-adenine-glycosylase
MLDLKEYGIEMWPEEKIQAFRKALLDWYDANKRDLPWRRTKDPYAIWVSEIMLQQTRVDTVIPYYERFLHYLPTISDLAQAPEEVILKLWEGLGYYSRVRNMQKAAQQMVEDFDGQFPTTHAAISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLSRLFEVDYDIGLPANRKIFQAMMELLIDPERPGDFNQALMDLGSDIESPVNPRPQDSPVKAFSAAYLNGTMDKYPIKAPKKKPIPVAYQGFLIRNKDNQFLLEKNNEAGLLSGFWSFPLLEKGAIVEKQVSLFEVAEEVVQPDIRQSFTELYGLTVDWQEQEFGIVQHIFSHRKWQIEMVEGVAETLNLPESKELKWVSVEDFPTYPFAKPQQKMWENFIKEKEKQKS
>NC_022516.1|WP_002936184.1|1101637_1102894_+|ISL3-family-transposase
MEQLNLITNFLRIKDKNIVITDEYDMGTHLELHGHLDYTAPKCPSCKGQMTKYDFQKASKIPYLETAGYPLLIRLRKRRFKCKDCGKIAVAETPLVKKNHQISVAVNQKIAQLLIENQAMTHIAHRLSISTSSVMRKLNEFKFETDWNTLPEVMSWDEYSFKKGKMSFIAQDFNSLNVITILDGRTQATIRNHFLRYPRKVRNQVKVITMDMFSPYYQLAKQLFPNAKIVLDRFHIVQHLSRAMNRIRIQIMNQFDRTSQEYRALKRYWKLIQQDSRKLSDKRFYRPMFRMHLTNKEILEKLLSFSEELRQHYELYQLLLFHFQEKNSDHFFDIVELEIATVNPIFQTVFKTFLKDKDKVLNALELPYSNAKLEATNNLIKVIKRNAFGFRNFENFKKRILIALNIKKERTKFVLSRC
>NC_022516.1|WP_002935234.1|1100564_1101365_+|helix-turn-helix-transcriptional-regulator
MILGDILKEYRSKNKLSMDKFAELSGLTKGYISMLEKNQHPKTKKALLPTMDTLEKVAKGMAISVGELIEQLDSNQDIALTITPSQFKLFQQPIHPEVQTLDNELKGDFHAQWLTFGQEQLAAMQTTSITPSASILHLDDYRERIDLPVPGKVSAGTGYWQDTDMNNLVSFYNDEIPDNQSYDTIAQVVGDSMAPHIEDGDYLFIRLTPHIPLNTIGIFSVNGENFVKKFKGDYLQSLNSDYDDIYFSPEDDIRPIGQVVDIYSPD
>NC_022516.1|WP_002935233.1|1099962_1100433_-|hypothetical-protein
MKRMTEISWNDIYKEWETYANHFGLTTPINTENLRDQKSKDFGKGSLITLDLLADYDTDSEKTAAIWVASFCRDLIQDYAYLLNGRAYLTVNQIYFQALKQFQSGAVIWSKPLTRLQPKLFVSYRLLENLDLSHYSCVVELAMLQASMVRTQILEK
>NC_022516.1|WP_002935232.1|1099400_1099943_-|hypothetical-protein
MFNLLNKKAEVSKVAEYWNDTLIERGILSADELLEGKCWRCKSSHGVAVCQIVSSKWSKDASLANQMVLCLSCQHEKPNVADTEIVWQWLEVENDERYWTLQGMAEYEKMYKKSVLQELWDMGIRDGEEVETLVNKVTSLSRKNDIVLNRATLAGLFRCEIEQMRRKAFLNWTGIFKLVS
>NC_022516.1|WP_002935231.1|1098143_1099175_+|tyrosine-type-recombinase/integrase
MATITKRGNSYRATVSLYKKGEYKRETKTFSNRKDAELWTLEMELEKGRGKNIAERSTLFPDFYRNWVHTVKKTDVREATFINYKRTLVIVDDLFDGIQLKHLDDLVMQKKIDQYAETHSKKTVKELVLKIRGSLKYAYARGLISNDFGHLLKSKGQEQPKSITEFKKLRQYCLSHTENEFNVLVALALETVARRGELLGIKKEDIFEYGIKILRSISPTNDDTRLKTKYSKRDISINEDVYQAVTKLAQTKEGYIFDWNGFKQASQLQKLLKQLGLTKTTFHGLRDTHASFLFSKDISLDYISRHLGHNSILTTQQYYLELMPEKKHQQDADALSLLNDLSL
>NC_022516.1|WP_009909915.1|1097019_1097775_+|hypothetical-protein
MALGNVEKDTEGWIELINQYLQYCIEIGLSPYTQATYKVALTKVLGVSSTNFIATQPRTRANRMNNRVLHKDYRLSNKNNDYWHKVVTSTGLRKSELIHVTGDALQRGRDGRWYLNLAGHKHHTKGRRDRWSPIMATSQEEEEWLVAIFQRAGEKKVFHVPKDLILDDFDGKKVPTALKSHKYPTEYAERVYRSVAREISKIRNRKEVIHLRKELVGISLNRKACKIVIKTLGHNRPEEFPRSYAYILLKR
>NC_022516.1|WP_002935226.1|1095973_1096741_-|DeoR/GlpR-transcriptional-regulator
MNKRERLEEITRLVNKKGTVRISEIVELLNVTDMTVRRDFIELEEQGVLTKIHGGARSNKAFQYREYSHSEKHIQNKEAKQEIAERAAQLIEDGDTVFLGPGTTVAFLAEAIKNSRLTVITNCMPVFTILSQKKTEEFQVFLLGGEYRQVTESFVGEITNTSLEKMRFSKIFFSGNGLKGTDVMTSTLAEAYTQNIAIKHSLEKYLLLDASKIGKDDFTSFCDLHDVTALVTDMNAKDENYQLLSKHIEIITTKL
>NC_022516.1|WP_002935225.1|1095345_1095768_-|galactose-6-phosphate-isomerase-subunit-LacA
MTIIIGADPAGSKLKDVIKDYLLEKSYDFKDVSDGSDFVDTTLAVVAEVNQQEGNLGIVIDAYGVGPFMTATKVKGMIAAEVSDERSAYMTRGHNNSRIITIGSEIVGEGIAKNIVKGFVEGEYDGGRHQIRVDMLNKMC
>NC_022516.1|WP_002935224.1|1094803_1095319_-|galactose-6-phosphate-isomerase-subunit-LacB
MKIAIGCDHIVTYEKIAVVDYLKNQGYEVLDFGTYDNVRTHYPIFGKKVGEAVASGQADLGICICGTGVGINNAVNKVPGVRSALVRDMTSALYAKEELNANVIGFGGKITGELLMCDIIEAFIKAEYKPTEANKRLIEKIAAVETLNQEQANPEFFTEFLEKWDRGEYQD
>NC_022516.1|WP_029694144.1|1104845_1105238_-|PaaI-family-thioesterase
MKVLDKLNLQPITVLDDYQATMLNEKEVLLTTKVTEKSLNPYGMAHGGFLFTLADSVAGLTTVAGGSYSVTLQSNIHYMKAAKLGDTLSVTGSCTHDGSRTKVVEVKIKNQDKQLLASASFTMFVTGKVE
>NC_022516.1|WP_002935237.1|1105221_1106964_-|ABC-transporter-ATP-binding-protein
MKQSSFKELVRLVLGQPFQMYLMLVGTLVQVLLTVYLPILIGQAVDAVLIADGQVLLGIIGKMVMVILLNTLVQWYLPLVTNRLVYGMVADLREQVYVKLHQMPLSYLDRHSVGDLVARFSSDSEQLTNGLLMVFNQFFIGILTIFLTIFTMARLDLTMMLLVVALTPVSLLVARYIAKKSYGYYRKQTQARGKQSQLLEESISQLTLVQSFNAQEQFTQGFQVVNDQYATYSQQAIFASSTVNPSTRFINAIIYALLAGLGALRIMAGQFTVGSLTTFLNYASQYSKPFNDISSVLSELQSALACADRLFAILALDSIDDQAERKIDSEELKGAISFDNVSFSYSPERSLIEHLDIDVEAGQKVAIVGPTGAGKSTMINLLMRFYDVTAGQIVLDGVPIRQYSREDLRRQIGMVLQETWIKSGTIHDNIAYGYPNATRELVIEAAKAANADFFIRQLPQGYDTVLADGGEGLSQGQRQLLSIARVFVKIPKILILDEATSSIDTRTEILVQEAFAKLMEGRTSFIIAHRLSTIQSADLILVMVDGKIVEQGNHEALMAEQGVYYQMQTSQQTEEDESVR
>NC_022516.1|WP_002935238.1|1106950_1108687_-|ABC-transporter-ATP-binding-protein
MKFLSRYFKDYIKESILGPVFKLLEACFELLVPLIIAYIVDTIIPNGSQGNLVAMLFLLVGLACIGIIVSLIAQYYSAKAAVGVTKELTNDLYQKVLSLPKSSRDILSSSSLLTRLTSDTLQIQTGINTFLRLFLRAPIVVFGSLIMAFYISPSLSAYFLEMIILLIFIVTVISVMTSRIYQSMRKELDGLVGQVRETVTGWRVIRAFGQREREIKAFQGINQIYKKQQLQAGFWSSLLSPLTFLVVNGTLLILIWQGNIAISHNLLEQGMLVALINYLLQILVELVKMIMVVSTLNQTYISAQRIQEVFDQTSEDVESSLPKVVSEDKEIIFSVRHISFSYPKSAEESLSDIAFDLRKGQFMGIIGGTGSGKSTLVDLLQALYSVPTNQLSLFIDGKSPKNLKEWRQQIAIVPQQAQLFAGTVRSNLSLGLESVLDSELWAALEIAQAKSFIEDKGGLDSPVEAFGKNFSGGQRQRLTIARAILQKAPILVLDDATSALDYLTESRLLAAIRRAFPAQTLIMVSQRTNSLRTADQILVFDQGRQVGLGRHEDLLRSSAIYQEIDQSQHREEDSHETI
>NC_022516.1|WP_002935239.1|1108688_1109663_-|phosphate-acetyltransferase
MKIFEQLATKLEGKKVRIVLPEGEEPRILQATKRLVNESDVVPVLLGNPDRIKIYLDIEGITEGFEIIDPAHYDRYDEMVAALVERRKGKVSEEQAHELLKDVNYFGVMLVYMGVVEGMVSGAIHSTASTVRPALQIIKTEPGVSKTSGAFLMVKGEERYIFGDCAINIDPDAQTLAEIAINSARTAKMFGIDPKVAMLSYSTKGSGAGPKVDKVVEATKIAQKLRPELDLDGELQFDAAFVPTTGKLKAPGSSVAGQATVFIFPGISAGNIGYKIAERMGGFAAVGPVLQGLNQPVNDLSRGCNPDDVYNLTLITAVQALEHR
>NC_022516.1|WP_002935240.1|1109680_1110574_-|RluA-family-pseudouridine-synthase
MRFEFIADQHTKIKTFLKKHGVSKGLLAKIKYTGGNIWVNDIEQNATYLLDIGDRVTIDIPAEEDLTGSLKPIFFPLDIVYEDDHFLSINKPVGYASIPSALHSSTIANFVKGYLIEQNYENKQVHIVTRLDRDTSGVMLFAKHGYAHARLDKQLQAKLIHKRYYALVKGNGQLEETGDIIAPIGRPEDSIITRCVTKNGKYAHTSYRVVQSWGDIHLVDIQLHTGRTHQIRVHFSHIGFPLLGDDMYGGSLECGIERQALHCHNLAFDNPFSAERIDLEAPLPEDFQAVINQLISK
>NC_022516.1|WP_032497578.1|1110573_1111401_-|NAD-kinase
MIQMKNTGRKKIALLASRNPKSEAVSKELWTKLKEANFILTPKNPDIVISIGGDGMLLSAFHKYEKLIDRVRFVGIHTGHLGFYTDYRDFEVDKLIENLKLDTGARVSYPILNVKVKMTDGRIVEARALNEATVKRLSKTMVADIIINNVPFERFRGDGISVSTPTGSTAYNKSLGGAVLHPTIEALQIAEVASLNNRVYRTLGSSVVVPKKDKIVIEPKHSDRYSIAVDNKTFVYDSIESIEYQIDNSKIHFVATPSHTSFWNRVKDAFIGEVE
>NC_022516.1|WP_002935242.1|1111375_1112047_-|GTP-pyrophosphokinase-family-protein
MDFNWEEFLDPYIQTVGELKIKLRGIRKQYRKANRHSPIEFVTGRVKPIESIKEKMALRHIKLENLAQDMQDIAGLRIMVQFVDDIEEVLAILRKRKDMQIVHERDYINNMKASGYRSYHVVIEYPVDTINGNETVLAEIQIRTLSMNFWATIEHSLNYKYKGNFPEEIKKRLEVTAKIAYELDEEMRKIRNDIQEAQALFDPAYRKLNDGVGNSDDTDEEYR
>NC_022516.1|WP_002935243.1|1112133_1112700_+|CYTH-domain-containing-protein
MKNHLEIEYKTLLTKSEYKRLLTDFSDVSPILQTNHYIDTPDLDMKNHRFSLRIRTFEDSAELTLKIPQEVGNQEYNQVLDIQTAHDLLENFQLPAGQISDIISATEIPLDKLAVWGILTTKRYEKQTSIGLMALDENDYVGQKDYELEVEVTDADAGKILFDEFLKKKSIQFKYASSKVARTAAHMK
>NC_022516.1|WP_013730387.1|1112844_1113822_+|ribose-phosphate-diphosphokinase
MVQPLGEHNIKLFSLNSNRDIAEKIADSAGIPLGKLSSRQFSDGEIQINIEESVRGVDVYIIQSTSYPVNNHLWELLIMIDACKRASANTITAVIPYFGYARQDRTASPREPITAKLVANMLVKAGVDRVLTLDLHASQIQGFFDIPVDNLLTEPLFAAYYMEKGLCGEDVVIVSPKNSGIKRARNIAEFLNAPIAIIDYAQDDSERSEGYIIGDVAGKKAILVDDILNTGRTFSQASKIVQEGGATEIYAVASHGLFAGTATQLLDEAPIKEILVTDSVASKEQHPKNIAFLTASDLIADAIHRIQEHQPLSPLFKFTSPEKEN
>NC_022516.1|WP_002935247.1|1113832_1114948_+|cysteine-desulfurase
MIYLDNAATTALSPTALQRMMEVAQENYGNPSSIHQSGRKANQRLRQSRQEIAQILSASPEQIIFTSGGSEADTLAIQGYALAHQSKGKHLITTAIEHHAVLHTMQYLEERFGFEVTYIQPVDQVITAQQIQDALRPDTILVSVMFANNETGQLLPIKEIGELLADHQAVFHVDAVQAIGKIAISPSNYGIDLLAASAHKFHGPKGTGFLYSKVHKFDSLIHGGKQEQQHRAGTENLPAIAAMATALTEQYESLDTHHQHVSELRQHIIEGLSGLDYYLNQAGPHLPHVLNIGFPGKLNEQLLMQLDLAGIAVSSGSACTAGVVQNSHVLEAMYGKDSHRLKESIRISLSEINTKEEIDTLIIELKKILGG

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Crispr_ID: NC_022516_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022516_3

1324796-1325489

TypeII

Consensus_repeat	Method
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CRISPRCasFinder
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CRT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	PILER-CR

10 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NC_022516_3

>merge|NC_022516|3|1324796-1325489|CRISPRCasFinder,CRT,PILER-CR
TGATTACGATAATATAAATCTTGAGAGTACAAAAACTACAAATGTTATGGGGATAACTACCAGAAGGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTAACTGAAAATTAGTAGCGTAAGGAAGTGGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACGACAAGGTCGAAAAGAAATACATTGATGTTGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACCCTGCAGATGTTAACCCACTCAATAATCCGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTTTCCTCTTTTACTTCTTTATTTGTTACTAGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTGGCCACGATGCGGTCCAAAGAGATAATTAGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACAAACTTTTTTGAAATTTGCTAAAAAAGTTCGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACCAGTATTAATTGGGATATTATTTATCTTAGGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACCAACATGGTTTTGATCCCACGTTTGGCCAGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACGAAAGGATTGGGACATATCCAAATTGTCGAGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>NC_022516|3|3|1324796-1325489|CRISPRCasFinder
TGATTACGATAATATAAATCTTGAGAGTACAAAAAC	TACAAATGTTATGGGGATAACTACCAGAAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TTAACTGAAAATTAGTAGCGTAAGGAAGTG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GACAAGGTCGAAAAGAAATACATTGATGTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CCTGCAGATGTTAACCCACTCAATAATCC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TTTCCTCTTTTACTTCTTTATTTGTTACTA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGGCCACGATGCGGTCCAAAGAGATAATTA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AAACTTTTTTGAAATTTGCTAAAAAAGTTC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAGTATTAATTGGGATATTATTTATCTTAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAACATGGTTTTGATCCCACGTTTGGCCA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GAAAGGATTGGGACATATCCAAATTGTCGA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>NC_022516|3|1|1324796-1325489|CRT
TGATTACGATAATATAAATCTTGAGAGTACAAAAAC	TACAAATGTTATGGGGATAACTACCAGAAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TTAACTGAAAATTAGTAGCGTAAGGAAGTG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GACAAGGTCGAAAAGAAATACATTGATGTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CCTGCAGATGTTAACCCACTCAATAATCC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TTTCCTCTTTTACTTCTTTATTTGTTACTA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGGCCACGATGCGGTCCAAAGAGATAATTA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AAACTTTTTTGAAATTTGCTAAAAAAGTTC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAGTATTAATTGGGATATTATTTATCTTAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAACATGGTTTTGATCCCACGTTTGGCCA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GAAAGGATTGGGACATATCCAAATTGTCGA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>NC_022516|3|1|1324994-1325489|PILER-CR
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CCTGCAGATGTTAACCCACTCAATAATCC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TTTCCTCTTTTACTTCTTTATTTGTTACTA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGGCCACGATGCGGTCCAAAGAGATAATTA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AAACTTTTTTGAAATTTGCTAAAAAAGTTC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAGTATTAATTGGGATATTATTTATCTTAG
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CAACATGGTTTTGATCCCACGTTTGGCCA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GAAAGGATTGGGACATATCCAAATTGTCGA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022516.1\|WP_013730440.1\|1322479_1323691_-\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NC_022516.1\|WP_002935611.1\|1333530_1334607_+\|hypothetical-protein	unknown	unknown	unknown
NC_022516.1\|WP_002935583.1\|1320556_1321270_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NC_022516.1\|WP_002935571.1\|1316178_1317306_-\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NC_022516.1\|WP_002935599.1\|1326592_1326916_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NC_022516.1\|WP_002935608.1\|1332045_1333419_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NC_022516.1\|WP_024390483.1\|1322123_1322480_-\|ArsC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|239332
NC_022516.1\|WP_009910394.1\|1337254_1338037_-\|TPM-domain-containing-protein	unknown	unknown	gnl\|CDD\|224429
NC_022516.1\|WP_002935602.1\|1327993_1331362_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|273840
NC_022516.1\|WP_009910385.1\|1318113_1320381_-\|glycogen/starch/alpha-glucan-family-phosphorylase	unknown	unknown	gnl\|CDD\|340853
NC_022516.1\|WP_009910392.1\|1334728_1335037_-\|hypothetical-protein	unknown	unknown	unknown
NC_022516.1\|WP_002935618.1\|1335125_1336589_-\|flotillin-family-protein	unknown	unknown	gnl\|CDD\|259798
NC_022516.1\|WP_013730441.1\|1324019_1324694_-\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NC_022516.1\|WP_002935598.1\|1325549_1326596_-\|hypothetical-protein	csn2	cd12217_csn2_CAS-II-A	gnl\|CDD\|213410
NC_022516.1\|WP_002935570.1\|1315207_1315948_-\|acyl-ACP-thioesterase	unknown	unknown	gnl\|CDD\|366738
NC_022516.1\|WP_002935621.1\|1336600_1337182_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
NC_022516.1\|WP_002935572.1\|1317400_1317979_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NC_022516.1\|WP_002935600.1\|1326912_1327827_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
NC_022516.1\|WP_002935585.1\|1321302_1322112_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NC_022516.1\|WP_002935569.1\|1314603_1315221_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240029

Protein	Function_ID	Function_description	E-value
NC_022516.1\|WP_013730440.1\|1322479_1323691_-\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NC_022516.1\|WP_002935583.1\|1320556_1321270_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	4.90632e-151
NC_022516.1\|WP_002935571.1\|1316178_1317306_-\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NC_022516.1\|WP_002935599.1\|1326592_1326916_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	9.7745e-25
NC_022516.1\|WP_002935608.1\|1332045_1333419_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NC_022516.1\|WP_024390483.1\|1322123_1322480_-\|ArsC-family-transcriptional-regulator	gnl\|CDD\|239332	cd03034, ArsC_ArsC, Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.	1.23912e-19
NC_022516.1\|WP_009910394.1\|1337254_1338037_-\|TPM-domain-containing-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	1.62582e-30
NC_022516.1\|WP_002935602.1\|1327993_1331362_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	3.20638e-178
NC_022516.1\|WP_009910385.1\|1318113_1320381_-\|glycogen/starch/alpha-glucan-family-phosphorylase	gnl\|CDD\|340853	cd04300, GT35_Glycogen_Phosphorylase, glycogen phosphorylase and similar proteins. This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism. The allosteric control mechanisms of yeast and mammalian members of this family are different from that of bacterial members. The members of this family belong to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	0
NC_022516.1\|WP_002935618.1\|1335125_1336589_-\|flotillin-family-protein	gnl\|CDD\|259798	cd03399, SPFH_flotillin, Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. The flotillin (reggie) like proteins are lipid raft-associated. Individual proteins of this SPFH family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. In addition, microdomains formed from flotillin proteins may be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and interact with a variety of proteins. They may play a role in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and in cancer invasion, and metastasis.	7.80101e-47
NC_022516.1\|WP_013730441.1\|1324019_1324694_-\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	3.34018e-113
NC_022516.1\|WP_002935598.1\|1325549_1326596_-\|hypothetical-protein	gnl\|CDD\|213410	cd12217, Stu0660_Csn2, Stu0660-like CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. This family of Csn2 proteins includes Stu0660, the proteins are larger than other (canonical) Csn2 proteins as they have an additional alpha-helical C-terminal domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	2.6417e-137
NC_022516.1\|WP_002935570.1\|1315207_1315948_-\|acyl-ACP-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	7.63063e-88
NC_022516.1\|WP_002935621.1\|1336600_1337182_-\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	8.85941e-67
NC_022516.1\|WP_002935572.1\|1317400_1317979_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	9.00811e-06
NC_022516.1\|WP_002935600.1\|1326912_1327827_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	2.0775e-122
NC_022516.1\|WP_002935585.1\|1321302_1322112_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	6.03224e-162
NC_022516.1\|WP_002935569.1\|1314603_1315221_-\|NUDIX-hydrolase	gnl\|CDD\|240029	cd04672, Nudix_Hydrolase_14, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.31442e-61

>NC_022516.1|WP_013730441.1|1324019_1324694_-|ribose-5-phosphate-isomerase-RpiA
MTNLKEQVGIKAAEFVTDGMIVGLGTGSTAYYFVQEIGRRVAEEGLQITGVTTSHATAEHAASLGIPLKNIDEVEYVDLTVDGADEVDGDFNGIKGGGAALLMEKVVAVNSKDCIWIVDESKVVQTLGAFKLPVEVVQYGAENLFRLFEKKGYRPSFRMRNGEKHITDMQNFIIDLDLRRIEDTYALAEELDRTVGVVEHGLFIGLISKVIVGTLEGPNIIEKK
>NC_022516.1|WP_013730440.1|1322479_1323691_-|phosphopentomutase
MPKFKRVHLVVMDSVGIGAAPDSDKFFNAGVADTESDTLGHISEKAGLEVPNMTKIGLGNIPRDTALATVPAESHPTGYVTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWDGFPEEILTKIEEFSGRKIIREANKPYSGTAVIDDFGPRQMETGELIVYTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFSRTANRHDYAVSPFKATVLNKLADAGVPTYSVGKISDIFNGSGITNDMGHTKSNMHGVDVLIDTLKLSDFEEGFSFTNLVDFDAVYGHRRNIEGYRDCLQEFDARIPEIIDNMREDDLLLITADHGNDPSYAGTDHTREYVPLLAYSKAFKGSGVLPVGYFADISATVAENFGVDTAMIGESFLSQLV
>NC_022516.1|WP_024390483.1|1322123_1322480_-|ArsC-family-transcriptional-regulator
MEKLTVYYNPNCSKCKKLRILLSSQDMEVKWVNYLETPLRGAELTALLEKMESQPSAVTRLKEEERLALSEEEIFERLVEEPATLNRPIIEREQTAFLCRPLEIIKEKMPEYDWSDYL
>NC_022516.1|WP_002935585.1|1321302_1322112_-|purine-nucleoside-phosphorylase
MSLLAKINETKTFLEEKGLVKPEFGLILGSGLGELAQEVENAIVIDYADIPNWGKSTVVGHAGKLVYGDLAGRKVLALQGRFHFYEGNPMEVVTFPVRVMKALGCEGVIVTNAAGGIGYGPGTLMAITDHINMTGQNPLIGENLEEFGPRFPDMSNAYTKEYREKAHAVAEKLGIKLDDGVYLGVTGPTYETPAEILAFKTMGAHAVGMSTVPEVIVAAHSGMKVLGISAITNFAAGFQSELNHEEVVEVTEQIKGNFKGLVKAILAEL
>NC_022516.1|WP_002935583.1|1320556_1321270_-|purine-nucleoside-phosphorylase
MSIHISAKPGEIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNMFGYTGTYKGHRVSVMGTGMGMPSISIYAHELINEYGVKKLIRVGTAGSLNEDVHVRELVLAQAAATNSRMINIDWPEYDLPQIADFDLLDKAYHIAKELNMTTHVGNVLSSDSFYSPKLFSRNLELGQLGVKAVEMEAAALYYLGAKFGVQTLAIMTISDSLVNPEENTTAEERQNTFTDMMKVGLETLIAE
>NC_022516.1|WP_009910385.1|1318113_1320381_-|glycogen/starch/alpha-glucan-family-phosphorylase
MINLQNFVQSMYAKRIEDCTDQELYYALLAFTKQQSEAKYTNDQKKKVYYISAEFLIGKLLSNNLINLGLYDEVKSQLVAAGKDLIAIEDMELEPSLGNGGLGRLAACFLDSIASLGLNGDGVGLNYHFGLFRQLFEYHQQSAVPNEWITPRSWLTESPISYQVPFANFTLTSKLYDIDVPGYKMERKNRLRLFDLGSVDDNIIYDGIEFDKEDIFRNLTLFLYPDDSTDEGKVLRIFQQYFMVSNAAQLLIDEAVAKGSNLHDLPDYAVVQINDTHPSLVIPELIRLLELRGISFDEAVEIVKKMTAYTNHTILSEALEKWPLDFLNYVVPHLVPFIVELDRRAKEVKDDPAVNIIDEYGRVHMAHMDIHYGYSINGVAALHTEILKTSELKAFYELYPEKFNNKTNGITFRRWLMHANPSLASYLDGLLGHGYHHDASELEKLLDYKNDKELKSWLEKTKQHNKRKLQRHIAKTQGVHVNPESIFDVQIKRMHEYKRQQMNVLYVIHKYLDIKAGNIPTRPLTVFFGGKAAPAYTTAQDIIHLILVLSQVIKNDSEVAPHLQLVMIENYNVTEASFIIPAADISEQISLASKEASGTGNMKFMLNGALTIGTDDGANVEIHELVGDENIYIFGQDSQTVIEHYANRTYHPYSFYEREVIRPLIDFITSDTIRHAGGIDERLWRLQDNLKHNDHFMTLLDLEDYIVTKERMLADYEDRDSWLEKVIVNIAKAGFFSSDRTIQQYNEDIWHLEAK
>NC_022516.1|WP_002935572.1|1317400_1317979_+|VanZ-family-protein
MKKEIIYDCINLILSFLLCRWLFMTFLFYQFSNIFMTIDFWPTLAAILLMTGFCFTLFRLVYKPHISRLTLWFFYACYGLLLVYLLFFKSMGVRGVNWNLLSTFSQDLFLNPTILVFNLLLFLPLGLLFSFSWKKLSLFVGAILLVEACQFFFSLGFFDLGDILLNTSGFALGNFLGQSAIAQSFKNRIQKK
>NC_022516.1|WP_002935571.1|1316178_1317306_-|oxygen-independent-coproporphyrinogen-III-oxidase
MKKRPTSAYIHIPFCTQICYYCDFSKVFIKNQPVDEYLAALMEEVKFYDLPALRTLYIGGGTPSALSADQLDYLLTNLEDLLDLSQLEEFTIEANPGDLTADKIAVLKKSKCNRVSLGVQTFDDRMLKKIGRSHNQAQIYETIATLKEAGFYNISIDLIYALPGQTMEQVVDNVAKALELDIPHMSLYSLILENHTVFMNRQRRGNLHLPNEDVESDMFDYILQELEKNGFEHYEISNFTKPGFESRHNLMYWDNSEYYGLGAGASGYIDGMRYRNRGPIQHYLKSIREKGHSRLHEEFLSQTEQMEEEMFLGLRKKTGVSIERFEEKFGISFEDRYGQVVRDLKNEGLLQEEDRWLRMTKKGLFLGDTVAERFI
>NC_022516.1|WP_002935570.1|1315207_1315948_-|acyl-ACP-thioesterase
MGLTYQEEFTIPFDMVDVKQEIKLPDFISYCLGVSGRQSEELGRSDLYVFQEFGLIWVVTDYELTIQRLPKYNETITIKTEAVAYNKFFCHRMFYIYDAAGNLLLDILCYFVLIDFETRKVAPVPEDLIAPYQSEQVKKLPRAPKYQLLENPSVQEFPVRYFDLDMNGHVNNGKYLEWMYEALGYDFLLCHVPKKIQLKYLKEVEATSLVSSRMVAEAGGSQHEIVVDGHIHAQAVIEWRERHVAG
>NC_022516.1|WP_002935569.1|1314603_1315221_-|NUDIX-hydrolase
MSQDKWLEWAVRLQALAQTGLAYGKDVYDMERFEEIRQIAAEMLVEPSGQPLEVVKDLFCNETGYQTPKLDTRAAIFQEDKILLVQENDGLWSLPGGWCDVDQSVKDNVVKEVKEEAGLDVEAQRVVAILDKHKNNPAKSAHRVTKVFILCRLLGGEFQPNSETVASGFFSLDDLPPLYLGKNTAEQLALCLEASRSEHWETRFD
>NC_022516.1|WP_002935598.1|1325549_1326596_-|hypothetical-protein
MKWLITHHVLNNIPIHVGQFTQIVGQNYELKYYIWQILIWYFGGKKYSEEDLILFNQEEPVISQDSEAIKRNAFKIISIAEVGDILEQISYKKGTIGFSYLSLKMQNIEIIEELEILNYHLHKIAQKVNSSISLINDEIEYEVGTTDLLPEQILTKQLTPHFKKSRDEIAIEFISNEKKLCFLLQMLNAIMQEQTKPILLVLKNLDDYLTYDSFVRIAQYLEELSNKYPYFNTILFPSQEGYLYLTEATLETVNIVSDRIEHYPAFTFLYTRYQQSYPSTSPLGEKEFLNSLRKISSYLFSSDINRVVSLADIDLVTLKIVNSLYQYDIKMVYMYKGISKLEENYLSS
>NC_022516.1|WP_002935599.1|1326592_1326916_-|CRISPR-associated-endonuclease-Cas2
MRYDAMRLLCFFDLPMETTQEKRQYRLFRKELIANGFEMLQFSVYYRTCPNRSFATKFYKKLQQSHLPAGNVRLLAVTEKQFSEMVLIVGGKTRQEEAISDRKLVII
>NC_022516.1|WP_002935600.1|1326912_1327827_-|type-II-CRISPR-associated-endonuclease-Cas1
MTWRIVHIHQSEKMRLKLDNLVIKKQGDEFTIPLSDISIIVAEGGDTVVTLRLLSALSKYNIALIVCDNHHLPTGIYHSQNGHFRAYKKLQAQLSWAPLQKDKLWQIIIYFKITNQQDVLAMQEKSLSTIQLLSDYREHIELGDRTNREGHAAKVYFNELFGKQFVRLTQQETDAVNAGLNYGYTIFRAQMARIIAGYGLNALIGIFHKNEYNQFNLADDLMEPFRQIVDVWVYMNLREADFLTYQHRLELTNLLNAKIRYGKENCSVTVAMDKFVKGFIRCIEDKDTNQFFCPVVSSLEMEKL
>NC_022516.1|WP_002935602.1|1327993_1331362_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MSNGKILGLDIGIASVGVGVIDAQTGEIIHASSRIFPSANAANNAERRTFRGSRRLIRRKKHRIKRLDDLFNDFHINLDGEMSTDNPYVLRVKGLSQKLTVEELYISIKNIMKRRGISYLDDAESDNEAGRSDYAKAIERNRQLLTSKTPGEIQLERLEKYGQLRGNFTIIDEEGQSQQIINVFSTSDYVKEVEKILDCQKMYHKFISDEFCDKLIELLREKRKYYVGPGNEKSRTDYGIYRTDGTTLENLFGILIGKCTFYPDQYRSSRASYTAQEFNFLNDLNNLTVPTETKKLSQEQKEFLVNYAKETSVLGAGKILQQIAKLADCKVEDIRGYRLDNKDKPELHTFETYRAMKGLVPLVDIGVLSREQLDILADILTLNTDFEGIREALKKQLPNVFDEKQVKGLASFRKSKSQLFAKGWHNLSQKIMLEVIPELYATSDEQMTILTRLGKFEKSSVAEYPSSINVDEITDEIYNPVVAKSIRQTIKIINASIKKWGEFDQIVIEMPRDRNEDEEKKRIADGQKANAKEKADSILRAAELYCAGKVLPDYVYNGHNQLATKIRLWYQQGERCIYTGQPISIHDLIHNQNQYEIDHILPLSLTFDDSLSNKVLVLATANQEKAQRTPYNYLKSATSAWSYREFKDYVTKRKGIGKKKCEYLTFEEDINGFEVRSKFIQRNLVDTRYASKVILNALQDYFKISGIQTKVSVVRGQFTSQLRHKWGIEKTRETYHHHAVDALIIAASSQLRLWKKQESPLVVDYQEGRQVDLETGEILELTDEQYKELVYQPPYQGFVNTISSSAFDNEILFSYQVDSKVNRKISDATIYATRNAQLGKDKTEGIYVLGKIKDIYTQAGYEAFLKRYTKDKTSFLMYHKDLDTWEKVIEIILRDYREYDEKGKEIGNPFERYRRENGYVKKYSRKGNGTAIKSLKYYDNKLGNHIDITPENSRNAVVLQSLKPWRTDVYFNKETGKYEFLGIKYSDLSFEKGTGEYGISQEKYDSIKIAEGVAKKSIFKFTLYKQDLLFIKDIENNFGKLLRFTSKNDTSKHYVELKPYDKNKFGTEEPLLPVLGNVAKSGQCIKGLNKSNISIYKVRTDILGYRHFIKQEGEHPQLKFKK
>NC_022516.1|WP_002935608.1|1332045_1333419_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MITKEFDTITAISTPLGEGAIGIVRLSGTDAFAIASKVFKGKDLATVPSHSLNYGHIIDPATGQVLDEVILGVMRSPKTFTREDVIEINTHGGIAVTNEILQLLIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDVIRAKTDKAMHNAVRQLDGSLSQLINDTRQEILNTLAQVEVNIDYPEYDDVEEATTELVREKTLQFQALLENLLRTARRGKILREGIATAIIGRPNVGKSSLLNNLLREEKAIVTDIAGTTRDVIEEYVNIKGVPLKLIDTAGIRETDDIVEKIGVERSKKALEEADLILLVLNASEPLTEQDRNLLAISDLANRIVLLNKTDLEEQIEADQLPEDVIRISVLKNQNIDQIEEKINQLFFENAGLVEQDATYLSNSRHISLIEQAVQSLQAVNDGLEMGMPVDLLQVDLTRCWQILGEITGDAAPDELITQLFSQFCLGK
>NC_022516.1|WP_002935611.1|1333530_1334607_+|hypothetical-protein
MKKLLICIVLLSCLVFPFIGWKLYAYQHNTITLTSEADFYLIYPGKVEAFQLNGQEPELLHTQKMNSEGYFGSGENYVIDSRYLVFANDQQKFINDNLISIDFNTGTVLRKPSQYSSYISGTDGQDFYTAGPYHILAQFDRNFDTIQTHVLNDDFIPNAPVMVDQTSVYLTGFVKDFTQEGPEENVLIVFDKKDFSKQEVFKYDNTIATGEGPWVNGTIYLPNLGKKTSEYTDIEQSSELLTFDTKTKTFSSVTLEHPSPSTLHALKDQKLLLIEHQNDMFSPISFTIYNTQTGQESYHRLDELNPRPYYIDHVRQLDGNRLLLILAGKALIYDWQAKKVLSQTILSENYVSGVWVND
>NC_022516.1|WP_009910392.1|1334728_1335037_-|hypothetical-protein
MKMFRNSKKSKLFIQKINELLSDSELKLSKALKFQLLEAMELCEKGSKISYLSYKIYPWVLEELALNRIQSDKLKMFKRYLEQERWKYYFGSALGMAFTSIR
>NC_022516.1|WP_002935618.1|1335125_1336589_-|flotillin-family-protein
MDFGFDILAIMIPIIVVVLFVLLFVFGYVSAKPNEAIVITGLGKPRTLIGRSGFMIPFIEKRSYISIEQFSTDVQTTDFVPTLDFINVKADAVVKVKVGISDELLNAAAQNFLNWKTADISASIQDVLEGNLREIIGQMELRDMVNNRQAFAEKVQSNAAPDLAKMGLEIIAFTVQSFTDDNDVIKNLGIDNIVTIQKDAANARAKAEREQAEVRAREDKAANDARVAADLEIAKKQNELAIEQANLKRQSDVQLAQANAAYGIEEQAQRKEIERATAEANIVKQQKEAEVKAEEVKVREQELSATIRKQAEAEKYARQQAAEADLIERQRKAEAELYETQREAEAQKARAEAAKYAAEQEAAGIEAKGRAEAEAIRLKLEAEAEGLSKKADAMAKFNDAAVTEMVVNVLPEIAKNIAAPLGNVDKITMYGEGNASKMVGDLMTTMDKTTEGLGLNVRDLISATLTGRAMSTGLLTAQETKEAEGDK
>NC_022516.1|WP_002935621.1|1336600_1337182_-|LemA-family-protein
MKKKWLAILLPILALLFLGMGAVGQYNGLVDSYAEVENAQANVDTQLQRRYDLIPNVVAAVKGAMEHEEEIFTAIAEARAKIGSSQVGTSDYNQAQSQLDSAVSRLLVVAENYPQLTANQQVSALITELEGTENRILVARKDYNSVATTYNKKIKRFPTSIYANLFGYEKVELFQATNDAATTVPSVDLSDKE
>NC_022516.1|WP_009910394.1|1337254_1338037_-|TPM-domain-containing-protein
MRKWKKIIIGCFAILTVCLLFAPTLARANQIPDRPTGTTVVDETQLLSSETIAEIDQLNRSWASTEQALQVGVYVTESLSSDIESLANETFRHWQVGFAGTDNGVLLVVAIADRAFRIETSDNAATVITDVEAKDILENAREFFRQEDYSGGISYIVNSIGDRFYGTSIGKNQLAAIEEGTSEKDDGFWLFLIVILIAILFGIIDKSSRGGGGPGNLLWMLVDDHHHYHNHHSSNSSSSSFGGGSWSGGGGGGGGASSGW

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022516_3	3.9\|1325359\|29\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325359-1325387	29	NC_022516.1	1036859-1036887	0	1.0
NC_022516_1	1.1\|74602\|25\|NC_022516\|CRISPRCasFinder	74602-74626	25	NC_022516.1	73079-73103	2	0.92

1. spacer 3.9|1325359|29|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to position: 1036859-1036887, mismatch: 0, identity: 1.0

caacatggttttgatcccacgtttggcca	CRISPR spacer
caacatggttttgatcccacgtttggcca	Protospacer
*****************************

2. spacer 1.1|74602|25|NC_022516|CRISPRCasFinder matches to position: 73079-73103, mismatch: 2, identity: 0.92

agtggacctttttgtcatgagcctg	CRISPR spacer
agtggacctttttatcatgagcatg	Protospacer
*************.******** **

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022516_3	3.3\|1324964\|30\|NC_022516\|CRISPRCasFinder,CRT	1324964-1324993	30	MK448982	Streptococcus phage Javan554, complete genome	21889-21918	0	1.0
NC_022516_3	3.10\|1325424\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325424-1325453	30	KX077891	Streptococcus phage phiJH1301-1, complete genome	6168-6197	3	0.9
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	MK448818	Streptococcus phage Javan597, complete genome	40648-40677	4	0.867
NC_022516_3	3.10\|1325424\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325424-1325453	30	MK448988	Streptococcus phage Javan578, complete genome	4734-4763	4	0.867
NC_022516_3	3.10\|1325424\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325424-1325453	30	KC348601	Streptococcus phage phi7917, complete genome	31057-31086	4	0.867
NC_022516_2	2.1\|1104740\|28\|NC_022516\|CRISPRCasFinder	1104740-1104767	28	NZ_CP043555	Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence	6368-6395	6	0.786
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_AP014865	Bacillus thuringiensis serovar tolworthi strain Pasteur Institute Standard strain plasmid pKK1, complete sequence	95334-95363	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	MT773554	Myoviridae sp. isolate BML_2 genomic sequence	208851-208880	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	MH830362	Enterococcus faecalis plasmid p4, complete sequence	59075-59104	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NC_006979	Streptococcus pyogenes plasmid pSM19035, complete sequence	4622-4651	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NC_006979	Streptococcus pyogenes plasmid pSM19035, complete sequence	12800-12829	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_LR135180	Enterococcus faecium isolate E0595 plasmid 2	49583-49612	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_CP023514	Enterococcus sp. FDAARGOS_375 plasmid unnamed1, complete sequence	115465-115494	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_CP049777	Enterococcus faecalis strain ES-1 plasmid unnamed2, complete sequence	4829-4858	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NC_006978	S.pyogenes plasmid pMD101 DNA	4622-4651	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NC_006978	S.pyogenes plasmid pMD101 DNA	12800-12829	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_CP045673	Bacillus subtilis strain 2014-3557 plasmid pGMrib, complete sequence	9754-9783	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_CP038866	Vagococcus sp. CF-49 plasmid punnamed1, complete sequence	19477-19506	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_AP018541	Enterococcus faecalis strain KUB3006 plasmid pKUB3006-3, complete sequence	4029-4058	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_CP028728	Enterococcus faecium strain FSIS1608820 plasmid pFSIS1608820, complete sequence	4980-5009	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_CP033741	Enterococcus sp. FDAARGOS_553 plasmid unnamed2, complete sequence	58987-59016	6	0.8
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	JN638751	Bacillus phage G, complete genome	457897-457926	6	0.8
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	MH552526	Siphoviridae sp. isolate ctfj46, complete genome	2642-2671	6	0.8
NC_022516_3	3.8\|1325293\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325293-1325322	30	MK448365	Streptococcus satellite phage Javan212, complete genome	12488-12517	6	0.8
NC_022516_3	3.8\|1325293\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325293-1325322	30	NZ_CP026119	Halobacillus litoralis strain ERB 031 plasmid pLDW-31, complete sequence	127386-127415	6	0.8
NC_022516_3	3.9\|1325359\|29\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325359-1325387	29	NZ_CP012032	Leptospira borgpetersenii serovar Ballum strain 56604 plasmid lbp2, complete sequence	6830-6858	6	0.793
NC_022516_2	2.1\|1104740\|28\|NC_022516\|CRISPRCasFinder	1104740-1104767	28	NZ_CP040462	Enterococcus sp. M190262 plasmid pM190262, complete sequence	148656-148683	7	0.75
NC_022516_3	3.1\|1324832\|30\|NC_022516\|CRISPRCasFinder,CRT	1324832-1324861	30	AJ609634	Bacteriophage EJ-1 proviral DNA, complete genome	6909-6938	7	0.767
NC_022516_3	3.1\|1324832\|30\|NC_022516\|CRISPRCasFinder,CRT	1324832-1324861	30	NC_005294	Streptococcus prophage EJ-1, complete genome	6909-6938	7	0.767
NC_022516_3	3.1\|1324832\|30\|NC_022516\|CRISPRCasFinder,CRT	1324832-1324861	30	KY065449	Streptococcus phage IPP5, complete genome	7026-7055	7	0.767
NC_022516_3	3.3\|1324964\|30\|NC_022516\|CRISPRCasFinder,CRT	1324964-1324993	30	NZ_CP013208	Paenibacillus sp. IHB B 3084 plasmid pHD05, complete sequence	11448-11477	7	0.767
NC_022516_3	3.3\|1324964\|30\|NC_022516\|CRISPRCasFinder,CRT	1324964-1324993	30	NZ_MG205643	Paeniclostridium sordellii strain S0804018 plasmid pCS1-5, complete sequence	56962-56991	7	0.767
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_CP050184	Bacillus thuringiensis strain HER1410 plasmid pLUSID1, complete sequence	168570-168599	7	0.767
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	MN698241	Pelagibacter phage HTVC027P, complete genome	2493-2522	7	0.767
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_KP342511	Enterococcus faecium isolate N12-493 plasmid pEfm12493, complete sequence	110379-110408	7	0.767
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	CP024687	Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-3-257K, complete sequence	25618-25647	7	0.767
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NC_018146	Zymomonas mobilis subsp. mobilis ATCC 29191 plasmid pZZ6.01, complete sequence	12440-12469	7	0.767
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	MK448723	Streptococcus phage Javan271, complete genome	40059-40088	7	0.767
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	MN694526	Marine virus AFVG_250M936, complete genome	24666-24695	7	0.767
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	MF417925	Uncultured Caudovirales phage clone 3F_9, partial genome	23924-23953	7	0.767
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP017876	Campylobacter coli strain ZV1224 plasmid pCCDM224S, complete sequence	24047-24076	7	0.767
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP044166	Campylobacter coli strain AR-0416 plasmid pAR-0416	173158-173187	7	0.767
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP017416	Campylobacter jejuni strain MTVDSCj07 plasmid pMTVDSCj07-1, complete sequence	40727-40756	7	0.767
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NC_022354	Campylobacter jejuni subsp. jejuni 00-2544 plasmid unnamed, complete sequence	7773-7802	7	0.767
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP031260	Klebsiella quasipneumoniae strain L22 plasmid pL22-3, complete sequence	10507-10536	7	0.767
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NC_019688	Clostridium perfringens plasmid pNetB-NE10, complete sequence	47718-47747	7	0.767
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP025502	Clostridium perfringens strain EHE-NE18 plasmid pJIR3535, complete sequence	55489-55518	7	0.767
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NC_009130	Staphylococcus sp. 693-2 plasmid pLEW6932, complete sequence	22159-22188	7	0.767
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP023413	Clostridium perfringens strain LLY_N11 plasmid pLLY_N11_3, complete sequence	46507-46536	7	0.767
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	JQ660954	Clostridium phage PhiS63, complete genome	24634-24663	7	0.767
NC_022516_3	3.8\|1325293\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325293-1325322	30	AP019559	Escherichia phage SP15 DNA, complete genome	91136-91165	7	0.767
NC_022516_3	3.8\|1325293\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325293-1325322	30	NZ_CP014221	Clostridium botulinum strain B515 plasmid pRSJ21_2, complete sequence	10259-10288	7	0.767
NC_022516_3	3.8\|1325293\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325293-1325322	30	NZ_CP013852	Clostridium botulinum strain B305 plasmid pRSJ6_2, complete sequence	8743-8772	7	0.767
NC_022516_3	3.8\|1325293\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325293-1325322	30	NZ_CP014172	Clostridium botulinum strain B609 plasmid pRSJ22_1, complete sequence	744-773	7	0.767
NC_022516_3	3.10\|1325424\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325424-1325453	30	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	319238-319267	7	0.767
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_CP016746	Lactococcus lactis subsp. cremoris strain JM1 plasmid pMPJM1, complete sequence	94403-94432	8	0.733
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	NZ_MG973074	Clostridioides difficile strain HSJD-312 plasmid pHSJD-312, complete sequence	26275-26304	8	0.733
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	KM236242	Escherichia phage Pollock, complete genome	39297-39326	8	0.733
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP017832	Butyrivibrio hungatei strain MB2003 plasmid pNP144, complete sequence	108253-108282	8	0.733
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP016287	Rhizobium leguminosarum strain Vaf10 plasmid unnamed1, complete sequence	698951-698980	8	0.733
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP053953	Bacillus cereus strain FDAARGOS_798 plasmid unnamed2, complete sequence	45174-45203	8	0.733
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP022565	Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK01, complete sequence	819513-819542	8	0.733
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP053950	Bacillus cereus strain FDAARGOS_799 plasmid unnamed2, complete sequence	267544-267573	8	0.733
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	MN694136	Marine virus AFVG_250M984, complete genome	28229-28258	8	0.733
NC_022516_3	3.8\|1325293\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325293-1325322	30	MT679222	Proteus phage 2, complete genome	96921-96950	8	0.733
NC_022516_3	3.8\|1325293\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325293-1325322	30	MT679223	Proteus phage 1, complete genome	97178-97207	8	0.733
NC_022516_3	3.8\|1325293\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325293-1325322	30	NZ_CP053952	Bacillus cereus strain FDAARGOS_798 plasmid unnamed1, complete sequence	451906-451935	8	0.733
NC_022516_3	3.8\|1325293\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325293-1325322	30	NZ_CP053949	Bacillus cereus strain FDAARGOS_799 plasmid unnamed1, complete sequence	101964-101993	8	0.733
NC_022516_3	3.5\|1325095\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325095-1325124	30	MK613349	Roseobacter phage CRP-7, complete genome	9357-9386	9	0.7
NC_022516_3	3.6\|1325161\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325161-1325190	30	NZ_CP011666	Streptomyces sp. Mg1 plasmid pSMg1-2, complete sequence	115042-115071	9	0.7
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP024322	Borrelia miyamotoi strain Yekat-6 plasmid pYkt6-3	8651-8680	9	0.7
NC_022516_3	3.7\|1325227\|30\|NC_022516\|CRISPRCasFinder,CRT,PILER-CR	1325227-1325256	30	NZ_CP024339	Borrelia miyamotoi strain Yekat-1 plasmid pYkt1-4	9770-9799	9	0.7

1. spacer 3.3|1324964|30|NC_022516|CRISPRCasFinder,CRT matches to MK448982 (Streptococcus phage Javan554, complete genome) position: , mismatch: 0, identity: 1.0

gacaaggtcgaaaagaaatacattgatgtt	CRISPR spacer
gacaaggtcgaaaagaaatacattgatgtt	Protospacer
******************************

2. spacer 3.10|1325424|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to KX077891 (Streptococcus phage phiJH1301-1, complete genome) position: , mismatch: 3, identity: 0.9

gaaaggattgggacatatccaaattgtcga	CRISPR spacer
aaaaggactggaacatatccaaattgtcga	Protospacer
.******.***.******************

3. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MK448818 (Streptococcus phage Javan597, complete genome) position: , mismatch: 4, identity: 0.867

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
aactttttttgaaatttggttaaaaagttc	Protospacer
** .************** * *********

4. spacer 3.10|1325424|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MK448988 (Streptococcus phage Javan578, complete genome) position: , mismatch: 4, identity: 0.867

gaaaggattgggacatatccaaattgtcga	CRISPR spacer
agaaggactggaacatatccaaattgtcga	Protospacer
..*****.***.******************

5. spacer 3.10|1325424|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to KC348601 (Streptococcus phage phi7917, complete genome) position: , mismatch: 4, identity: 0.867

gaaaggattgggacatatccaaattgtcga	CRISPR spacer
agaaggactggaacatatccaaattgtcga	Protospacer
..*****.***.******************

6. spacer 2.1|1104740|28|NC_022516|CRISPRCasFinder matches to NZ_CP043555 (Vibrio cholerae strain RFB16 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.786

catttctacaaaggtttggggaaacttg	CRISPR spacer
aatttctacaaagttttggggaaggtat	Protospacer
 ************ *********. *

7. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP014865 (Bacillus thuringiensis serovar tolworthi strain Pasteur Institute Standard strain plasmid pKK1, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttctttatttgttacta	CRISPR spacer
agtattcttttaattctttatttgttactg	Protospacer
  * .******* ****************.

8. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MT773554 (Myoviridae sp. isolate BML_2 genomic sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttctttatttgttacta	CRISPR spacer
tttcctcttttaactctttatttgcaagaa	Protospacer
************ .**********. *  *

9. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MH830362 (Enterococcus faecalis plasmid p4, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

10. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NC_006979 (Streptococcus pyogenes plasmid pSM19035, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

11. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NC_006979 (Streptococcus pyogenes plasmid pSM19035, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

12. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_LR135180 (Enterococcus faecium isolate E0595 plasmid 2) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

13. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP023514 (Enterococcus sp. FDAARGOS_375 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

14. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP049777 (Enterococcus faecalis strain ES-1 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

15. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NC_006978 (S.pyogenes plasmid pMD101 DNA) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

16. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NC_006978 (S.pyogenes plasmid pMD101 DNA) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

17. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP045673 (Bacillus subtilis strain 2014-3557 plasmid pGMrib, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

18. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP038866 (Vagococcus sp. CF-49 plasmid punnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

19. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP018541 (Enterococcus faecalis strain KUB3006 plasmid pKUB3006-3, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

20. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP028728 (Enterococcus faecium strain FSIS1608820 plasmid pFSIS1608820, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

21. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP033741 (Enterococcus sp. FDAARGOS_553 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.8

tttcctcttttacttcttta-tttgttacta	CRISPR spacer
cgtcctctttttcttctttattttgttgtt-	Protospacer
. ********* ******** ******..*

22. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to JN638751 (Bacillus phage G, complete genome) position: , mismatch: 6, identity: 0.8

tttcctcttttacttctttatttgttacta	CRISPR spacer
tttcttcttttagttctttattttcaactg	Protospacer
****.******* ********** . ***.

23. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MH552526 (Siphoviridae sp. isolate ctfj46, complete genome) position: , mismatch: 6, identity: 0.8

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
taggttttttgaaattttttaaaaaagttt	Protospacer
 *. ************* .**********.

24. spacer 3.8|1325293|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MK448365 (Streptococcus satellite phage Javan212, complete genome) position: , mismatch: 6, identity: 0.8

cagtattaattgggatattatttatcttag	CRISPR spacer
tagtattaattggaatagtatttatctctt	Protospacer
.************.*** *********.

25. spacer 3.8|1325293|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP026119 (Halobacillus litoralis strain ERB 031 plasmid pLDW-31, complete sequence) position: , mismatch: 6, identity: 0.8

cagtattaattgggatattatttatcttag	CRISPR spacer
gagtattaattgggttattatttattgttc	Protospacer
 ************* **********. *

26. spacer 3.9|1325359|29|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP012032 (Leptospira borgpetersenii serovar Ballum strain 56604 plasmid lbp2, complete sequence) position: , mismatch: 6, identity: 0.793

caacatggttttgatcccacgtttggcca	CRISPR spacer
aaaatcggtttttttcccacgtttggcca	Protospacer
 **  .******  ***************

27. spacer 2.1|1104740|28|NC_022516|CRISPRCasFinder matches to NZ_CP040462 (Enterococcus sp. M190262 plasmid pM190262, complete sequence) position: , mismatch: 7, identity: 0.75

catttctacaaaggtttggggaaacttg	CRISPR spacer
catttctacaacggtttgcggaacaaat	Protospacer
*********** ****** ****

28. spacer 3.1|1324832|30|NC_022516|CRISPRCasFinder,CRT matches to AJ609634 (Bacteriophage EJ-1 proviral DNA, complete genome) position: , mismatch: 7, identity: 0.767

tacaaatgttatggggataactaccagaag	CRISPR spacer
taaaaatgttaaggggataactaaagaaac	Protospacer
** ******** ***********  ..**

29. spacer 3.1|1324832|30|NC_022516|CRISPRCasFinder,CRT matches to NC_005294 (Streptococcus prophage EJ-1, complete genome) position: , mismatch: 7, identity: 0.767

tacaaatgttatggggataactaccagaag	CRISPR spacer
taaaaatgttaaggggataactaaagaaac	Protospacer
** ******** ***********  ..**

30. spacer 3.1|1324832|30|NC_022516|CRISPRCasFinder,CRT matches to KY065449 (Streptococcus phage IPP5, complete genome) position: , mismatch: 7, identity: 0.767

tacaaatgttatggggataactaccagaag	CRISPR spacer
taaaaatgttaaggggataactaaagaaac	Protospacer
** ******** ***********  ..**

31. spacer 3.3|1324964|30|NC_022516|CRISPRCasFinder,CRT matches to NZ_CP013208 (Paenibacillus sp. IHB B 3084 plasmid pHD05, complete sequence) position: , mismatch: 7, identity: 0.767

gacaaggtcgaaaagaaatacattgatgtt	CRISPR spacer
aagcaggacgaaaagaaatccattgatgca	Protospacer
.*  *** *********** ********.

32. spacer 3.3|1324964|30|NC_022516|CRISPRCasFinder,CRT matches to NZ_MG205643 (Paeniclostridium sordellii strain S0804018 plasmid pCS1-5, complete sequence) position: , mismatch: 7, identity: 0.767

gacaaggtcgaaaagaaatacattgatgtt	CRISPR spacer
gatacacccgaaaagaaagacattgatgtc	Protospacer
**.* . .********** **********.

33. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP050184 (Bacillus thuringiensis strain HER1410 plasmid pLUSID1, complete sequence) position: , mismatch: 7, identity: 0.767

tttcctcttttacttctttatttgttacta	CRISPR spacer
agtattcctttaattctttatttgttactg	Protospacer
  * .**.**** ****************.

34. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MN698241 (Pelagibacter phage HTVC027P, complete genome) position: , mismatch: 7, identity: 0.767

tttcctcttttacttctttatttgttacta	CRISPR spacer
atatttcttttacttttttatttgatactt	Protospacer
 * ..**********.******** ****

35. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_KP342511 (Enterococcus faecium isolate N12-493 plasmid pEfm12493, complete sequence) position: , mismatch: 7, identity: 0.767

tttcctcttttacttctttatttgttacta	CRISPR spacer
ctgtatcttttacatctttacttgttacaa	Protospacer
.* . ******** ******.******* *

36. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to CP024687 (Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-3-257K, complete sequence) position: , mismatch: 7, identity: 0.767

tttcctcttttacttctttatttgttacta-	CRISPR spacer
tttcctctattacttctttatct-ccatcat	Protospacer
******** ************.* ..*..*

37. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NC_018146 (Zymomonas mobilis subsp. mobilis ATCC 29191 plasmid pZZ6.01, complete sequence) position: , mismatch: 7, identity: 0.767

tttcctcttttacttctttatttgttacta	CRISPR spacer
cattctcttttacttctttagttcttagtg	Protospacer
. *.**************** ** *** *.

38. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MK448723 (Streptococcus phage Javan271, complete genome) position: , mismatch: 7, identity: 0.767

tttcctcttttacttctttatttgttacta	CRISPR spacer
tttcctcttttgcttatttattttatatac	Protospacer
***********.*** *******  **.

39. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MN694526 (Marine virus AFVG_250M936, complete genome) position: , mismatch: 7, identity: 0.767

tttcctcttttacttctttatttgttacta	CRISPR spacer
tttcttcttttacttttttatttataggaa	Protospacer
****.**********.*******.* .  *

40. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MF417925 (Uncultured Caudovirales phage clone 3F_9, partial genome) position: , mismatch: 7, identity: 0.767

tttcctcttttacttctttatttgttacta	CRISPR spacer
ttttctcttttacttctttataagattttt	Protospacer
***.*****************  * * .*

41. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017876 (Campylobacter coli strain ZV1224 plasmid pCCDM224S, complete sequence) position: , mismatch: 7, identity: 0.767

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
cttattttttaaaatttgctaaaatagtcc	Protospacer
    ******.************* ***.*

42. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP044166 (Campylobacter coli strain AR-0416 plasmid pAR-0416) position: , mismatch: 7, identity: 0.767

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
cttattttttaaaatttgctaaaatagtcc	Protospacer
    ******.************* ***.*

43. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017416 (Campylobacter jejuni strain MTVDSCj07 plasmid pMTVDSCj07-1, complete sequence) position: , mismatch: 7, identity: 0.767

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
cttattttttaaaatttgctaaaatagtcc	Protospacer
    ******.************* ***.*

44. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NC_022354 (Campylobacter jejuni subsp. jejuni 00-2544 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
cttattttttaaaatttgctaaaatagtcc	Protospacer
    ******.************* ***.*

45. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP031260 (Klebsiella quasipneumoniae strain L22 plasmid pL22-3, complete sequence) position: , mismatch: 7, identity: 0.767

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
aaggaaattagaaatttgctaaaaaagtac	Protospacer
**.    ** ****************** *

46. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NC_019688 (Clostridium perfringens plasmid pNetB-NE10, complete sequence) position: , mismatch: 7, identity: 0.767

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
gaaatgctttgaaatttgcaaaaaaagtaa	Protospacer
.** * .************ ********

47. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP025502 (Clostridium perfringens strain EHE-NE18 plasmid pJIR3535, complete sequence) position: , mismatch: 7, identity: 0.767

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
gaaatgctttgaaatttgcaaaaaaagtaa	Protospacer
.** * .************ ********

48. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NC_009130 (Staphylococcus sp. 693-2 plasmid pLEW6932, complete sequence) position: , mismatch: 7, identity: 0.767

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
aaggaaattagaaatttgctaaaaaagtac	Protospacer
**.    ** ****************** *

49. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP023413 (Clostridium perfringens strain LLY_N11 plasmid pLLY_N11_3, complete sequence) position: , mismatch: 7, identity: 0.767

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
gaaatgctttgaaatttgcaaaaaaagtaa	Protospacer
.** * .************ ********

50. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to JQ660954 (Clostridium phage PhiS63, complete genome) position: , mismatch: 7, identity: 0.767

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
atgctcttttgaaatttgctaaagaaaata	Protospacer
* .**.*****************.**. *

51. spacer 3.8|1325293|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to AP019559 (Escherichia phage SP15 DNA, complete genome) position: , mismatch: 7, identity: 0.767

cagtattaattgggatattatttatcttag	CRISPR spacer
cagtatttaatgggatattatttagaacaa	Protospacer
******* * **************   .*.

52. spacer 3.8|1325293|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP014221 (Clostridium botulinum strain B515 plasmid pRSJ21_2, complete sequence) position: , mismatch: 7, identity: 0.767

cagtattaattgggatattatttatcttag	CRISPR spacer
taagactaattgggatagtatttttcttat	Protospacer
.*. *.*********** ***** *****

53. spacer 3.8|1325293|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP013852 (Clostridium botulinum strain B305 plasmid pRSJ6_2, complete sequence) position: , mismatch: 7, identity: 0.767

cagtattaattgggatattatttatcttag	CRISPR spacer
taagactaattgggatagtatttttcttat	Protospacer
.*. *.*********** ***** *****

54. spacer 3.8|1325293|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP014172 (Clostridium botulinum strain B609 plasmid pRSJ22_1, complete sequence) position: , mismatch: 7, identity: 0.767

cagtattaattgggatattatttatcttag	CRISPR spacer
taagactaattgggatagtatttttcttat	Protospacer
.*. *.*********** ***** *****

55. spacer 3.10|1325424|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 7, identity: 0.767

gaaaggattgggacatatccaaattgtcga	CRISPR spacer
gaaaggattgggacatttctaaaggatcag	Protospacer
**************** **.***  .**..

56. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP016746 (Lactococcus lactis subsp. cremoris strain JM1 plasmid pMPJM1, complete sequence) position: , mismatch: 8, identity: 0.733

tttcctcttttacttctttatttgttacta	CRISPR spacer
gtgcctcttttaattctttttttgttttct	Protospacer
 * ********* ****** ****** ..

57. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_MG973074 (Clostridioides difficile strain HSJD-312 plasmid pHSJD-312, complete sequence) position: , mismatch: 8, identity: 0.733

tttcctcttttacttctttatttgttacta	CRISPR spacer
aatatattttttcttctttattttttacta	Protospacer
  * . .**** *********** ******

58. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to KM236242 (Escherichia phage Pollock, complete genome) position: , mismatch: 8, identity: 0.733

tttcctcttttacttctttatttgttacta	CRISPR spacer
gtagtacttttacttctttctctgttactt	Protospacer
 *  . ************* *.*******

59. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017832 (Butyrivibrio hungatei strain MB2003 plasmid pNP144, complete sequence) position: , mismatch: 8, identity: 0.733

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
agtgttttttgaaatttgctaaaaagcaca	Protospacer
*.  *********************.  .

60. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP016287 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
cgttatttttgaaatttgctcaaaaacatc	Protospacer
 . . *************** *****  **

61. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP053953 (Bacillus cereus strain FDAARGOS_798 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
atgaaatttcgaaatttgctaaagaagtta	Protospacer
* .   ***.*************.*****

62. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP022565 (Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK01, complete sequence) position: , mismatch: 8, identity: 0.733

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
cgttatttttgaaatttgctcaaaaacatc	Protospacer
 . . *************** *****  **

63. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP053950 (Bacillus cereus strain FDAARGOS_799 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
atgaaatttcgaaatttgctaaagaagtta	Protospacer
* .   ***.*************.*****

64. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MN694136 (Marine virus AFVG_250M984, complete genome) position: , mismatch: 8, identity: 0.733

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
tagagctttttaaatttgctaagaaagtta	Protospacer
 *.  .**** ***********.******

65. spacer 3.8|1325293|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MT679222 (Proteus phage 2, complete genome) position: , mismatch: 8, identity: 0.733

cagtattaattgggatattatttatcttag	CRISPR spacer
tcgtattagttgggatattagttatccgta	Protospacer
. ******.*********** *****.  .

66. spacer 3.8|1325293|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MT679223 (Proteus phage 1, complete genome) position: , mismatch: 8, identity: 0.733

cagtattaattgggatattatttatcttag	CRISPR spacer
tcgtattagttgggatattagttatccgta	Protospacer
. ******.*********** *****.  .

67. spacer 3.8|1325293|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP053952 (Bacillus cereus strain FDAARGOS_798 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

cagtattaattgggatattatttatcttag	CRISPR spacer
agagattgattgggatattttttatcttga	Protospacer
 .. ***.*********** ********..

68. spacer 3.8|1325293|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP053949 (Bacillus cereus strain FDAARGOS_799 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

cagtattaattgggatattatttatcttag	CRISPR spacer
agagattgattgggatattttttatcttga	Protospacer
 .. ***.*********** ********..

69. spacer 3.5|1325095|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to MK613349 (Roseobacter phage CRP-7, complete genome) position: , mismatch: 9, identity: 0.7

tttcctcttttacttctttatttgttacta	CRISPR spacer
ggattacttttacttctttctttgttagtt	Protospacer
   .. ************* ******* *

70. spacer 3.6|1325161|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP011666 (Streptomyces sp. Mg1 plasmid pSMg1-2, complete sequence) position: , mismatch: 9, identity: 0.7

tggccacgatgcggtccaaagagataatta	CRISPR spacer
cggccacgatgcggttcaaagacgccacct	Protospacer
.**************.****** .. *..

71. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP024322 (Borrelia miyamotoi strain Yekat-6 plasmid pYkt6-3) position: , mismatch: 9, identity: 0.7

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
taagttttttgaaatttgataaaaggagaa	Protospacer
 ** ************** *****...

72. spacer 3.7|1325227|30|NC_022516|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP024339 (Borrelia miyamotoi strain Yekat-1 plasmid pYkt1-4) position: , mismatch: 9, identity: 0.7

aaacttttttgaaatttgctaaaaaagttc	CRISPR spacer
taagttttttgaaatttgataaaaggagaa	Protospacer
 ** ************** *****...

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

33479 : 43539

Synechococcus_phage(28.57%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_024390481.1\|33479_37199_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	3.0e-39	27.3
WP_009908857.1\|37201_38656_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	9.4e-58	35.4
WP_009908859.1\|38711_39734_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FGG1	Synechococcus_phage	3.0e-58	41.1
WP_009908860.1\|39730_40282_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.1e-26	38.5
WP_002935323.1\|40291_41839_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	8.5e-73	47.0
WP_002935322.1\|41903_42734_+	DNA adenine methylase	A0A1S5PRR3	Streptococcus_phage	7.7e-89	59.3
WP_032499218.1\|42723_43539_+	site-specific DNA-methyltransferase	A0A1W6JJW1	Lactococcus_phage	1.1e-26	33.5

DBSCAN-SWA_2

316364 : 390705

Streptococcus_phage(27.27%)

holin,tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_086558053.1\|316364_317657_-\|transposase	IS110-like element ISSsu7 family transposase	A0A1X9I619	Streptococcus_phage	1.4e-225	100.0
WP_162467391.1\|317800_317941_-	hypothetical protein	NA	NA	NA	NA
WP_002937476.1\|318458_318674_-	helix-turn-helix transcriptional regulator	A0A0E3U244	Fusobacterium_phage	8.0e-06	29.9
WP_013730132.1\|318675_319200_-	hypothetical protein	NA	NA	NA	NA
WP_013730133.1\|321360_321816_-	transcriptional repressor	NA	NA	NA	NA
WP_002937468.1\|321982_322732_+\|tRNA	tRNA pseudouridine(38-40) synthase TruA	NA	NA	NA	NA
WP_002937466.1\|322721_323483_+	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	NA	NA	NA	NA
WP_002937464.1\|323472_323958_+	ECF transporter S component	NA	NA	NA	NA
WP_002937462.1\|323938_324505_+	TIGR01440 family protein	NA	NA	NA	NA
WP_002937456.1\|324504_325119_+	DUF1349 domain-containing protein	NA	NA	NA	NA
WP_002937454.1\|325391_325823_+	Rrf2 family transcriptional regulator	NA	NA	NA	NA
WP_002937449.1\|325902_326904_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_002937445.1\|326929_327775_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_002937439.1\|327767_328637_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_002937437.1\|328629_329841_+	NADH:flavin oxidoreductase/NADH oxidase family protein	NA	NA	NA	NA
WP_002937436.1\|330107_330617_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_002937435.1\|330759_331878_+	pectin acetylesterase	NA	NA	NA	NA
WP_013730135.1\|331887_332907_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_002937432.1\|333128_334412_+	trigger factor	NA	NA	NA	NA
WP_002937352.1\|334462_335347_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_002937351.1\|335456_336377_+	zinc ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_002937350.1\|336410_339566_+	pneumococcal-type histidine triad protein	NA	NA	NA	NA
WP_144063153.1\|339646_340997_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	2.2e-64	51.5
WP_009909339.1\|342325_343930_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	4.4e-141	46.6
WP_013730139.1\|344541_345423_+	fructose-bisphosphate aldolase	NA	NA	NA	NA
WP_001140948.1\|345817_346006_+	50S ribosomal protein L28	NA	NA	NA	NA
WP_051314132.1\|354361_355618_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	1.0e-172	73.4
WP_004194297.1\|356705_357551_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_004194296.1\|357552_358071_+	haloacid dehalogenase	A0A0H3UZF4	Geobacillus_virus	8.9e-19	35.5
WP_004194294.1\|358086_358539_-	universal stress protein	NA	NA	NA	NA
WP_002937606.1\|358693_359908_+	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_013730143.1\|360378_361167_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_011921928.1\|363750_364098_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_002939046.1\|365175_365478_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_022540555.1\|365477_366944_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_002939042.1\|366943_368383_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_074390696.1\|368700_368856_+\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_002939037.1\|369158_370157_-	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	5.0e-10	25.7
WP_002939036.1\|370289_371462_+	galactokinase	NA	NA	NA	NA
WP_009909376.1\|371471_372953_+	UDP-glucose--hexose-1-phosphate uridylyltransferase	NA	NA	NA	NA
WP_162467393.1\|374124_375417_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	3.5e-213	93.8
WP_002935151.1\|376446_376821_+	hypothetical protein	NA	NA	NA	NA
WP_002935150.1\|377004_377532_+	YqeG family HAD IIIA-type phosphatase	NA	NA	NA	NA
WP_011922650.1\|377532_378639_+	ribosome biogenesis GTPase YqeH	NA	NA	NA	NA
WP_024379048.1\|378957_379269_+	ribosome assembly RNA-binding protein YhbY	NA	NA	NA	NA
WP_002935147.1\|379281_379914_+	nicotinate-nucleotide adenylyltransferase	G3MA22	Bacillus_virus	2.0e-20	33.8
WP_013730149.1\|379910_380498_+	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	NA	NA	NA	NA
WP_002935141.1\|380952_381462_+	cysteine hydrolase	NA	NA	NA	NA
WP_002935140.1\|381463_381823_+	ribosome silencing factor	NA	NA	NA	NA
WP_009909388.1\|382279_383026_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_024390442.1\|383026_384808_+	hypothetical protein	NA	NA	NA	NA
WP_002935136.1\|384851_385940_+	nucleotidyltransferase	NA	NA	NA	NA
WP_002935135.1\|385941_386322_+	TipAS antibiotic-recognition domain-containing protein	NA	NA	NA	NA
WP_013730152.1\|386381_387761_+	hypothetical protein	NA	NA	NA	NA
WP_004194216.1\|387780_388191_+	peptide deformylase	A0A2I7QLT9	Vibrio_phage	2.1e-10	34.2
WP_013730153.1\|388605_390705_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	7.4e-120	38.1

DBSCAN-SWA_3

430442 : 453794

Streptococcus_phage(97.06%)

portal,integrase

attL 433231:433248|attR 451785:451802

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002937018.1\|430442_431843_+	Cof-type HAD-IIB family hydrolase	A0A1V0S9I2	Catovirus	2.3e-24	43.5
WP_002937017.1\|431844_432216_+	S1 RNA-binding domain-containing protein	NA	NA	NA	NA
WP_002937015.1\|432242_433169_-	cysteine synthase A	A0A1X9I5F1	Streptococcus_phage	9.9e-170	100.0
433231:433248	attL	NA	NA	NA	NA
WP_013730163.1\|433398_434556_-\|integrase	site-specific integrase	A0A1X9I5C3	Streptococcus_phage	5.0e-219	99.7
WP_013730164.1\|434752_435484_-	hypothetical protein	A0A1X9I5E4	Streptococcus_phage	3.7e-103	100.0
WP_013730165.1\|435531_435915_-	ImmA/IrrE family metallo-endopeptidase	A0A1X9I5R2	Streptococcus_phage	2.9e-67	100.0
WP_002937004.1\|435921_436302_-	helix-turn-helix transcriptional regulator	A0A1X9I5A1	Streptococcus_phage	3.9e-64	100.0
WP_002937001.1\|436486_436687_+	helix-turn-helix transcriptional regulator	A0A1X9I583	Streptococcus_phage	9.6e-30	100.0
WP_013730166.1\|436756_437083_+	hypothetical protein	A0A1X9I594	Streptococcus_phage	8.0e-58	100.0
WP_013730167.1\|437156_437411_+	hypothetical protein	A0A1X9I581	Streptococcus_phage	9.7e-43	100.0
WP_013730168.1\|437451_437700_+	hypothetical protein	A0A1X9I6Q0	Streptococcus_phage	1.1e-38	100.0
WP_022540561.1\|437689_437842_+	hypothetical protein	A0A1X9I663	Streptococcus_phage	2.0e-19	100.0
WP_013730169.1\|437846_438188_+	hypothetical protein	A0A1X9I5G6	Streptococcus_phage	2.1e-56	100.0
WP_013730170.1\|438187_438667_+	siphovirus Gp157 family protein	A0A1X9I5D2	Streptococcus_phage	4.8e-67	100.0
WP_013730171.1\|438663_438909_+	hypothetical protein	A0A1X9I5F0	Streptococcus_phage	4.3e-40	100.0
WP_013730172.1\|438889_439354_+	hypothetical protein	A0A1X9I5S7	Streptococcus_phage	7.1e-84	100.0
WP_013730173.1\|439322_440495_+	hypothetical protein	M1PF69	Streptococcus_phage	7.0e-229	98.7
WP_013730174.1\|440515_440836_+	hypothetical protein	A1EAC9	Streptococcus_phage	4.6e-50	94.3
WP_013730175.1\|440845_441544_+	ERF family protein	A0A1X9I5A9	Streptococcus_phage	2.2e-113	100.0
WP_022540564.1\|441543_441840_+	hypothetical protein	A0A1X9I5B1	Streptococcus_phage	1.6e-52	100.0
WP_022540565.1\|441836_442235_+	single-stranded DNA-binding protein	A0A1X9I6R5	Streptococcus_phage	2.7e-68	100.0
WP_013730177.1\|442245_443073_+	bifunctional DNA primase/polymerase	A0A1X9I684	Streptococcus_phage	4.6e-158	100.0
WP_079253058.1\|443056_444436_+	helicase	A0A1X9I5H6	Streptococcus_phage	3.8e-266	99.8
WP_013730179.1\|444813_444969_+	hypothetical protein	A0A1X9I5E8	Streptococcus_phage	9.7e-22	100.0
WP_013730180.1\|444965_445274_+	DUF1372 family protein	A0A1X9I5G5	Streptococcus_phage	3.8e-49	100.0
WP_013730181.1\|445275_445491_+	hypothetical protein	A0A1X9I5W1	Streptococcus_phage	9.7e-36	100.0
WP_013730182.1\|445679_445994_+	hypothetical protein	A0A1X9I5C1	Streptococcus_phage	5.2e-54	100.0
WP_002937915.1\|446066_446501_+	DUF1492 domain-containing protein	A0A1X9I5B5	Streptococcus_phage	2.0e-72	100.0
WP_013730183.1\|446597_446945_+	HNH endonuclease	A0A1X9I5C9	Streptococcus_phage	1.3e-61	100.0
WP_029694150.1\|447026_447395_+	hypothetical protein	A0A1X9I6S2	Streptococcus_phage	1.3e-40	100.0
WP_013730185.1\|447391_448657_+\|portal	phage portal protein	A0A1X9I693	Streptococcus_phage	5.4e-243	100.0
WP_013730186.1\|448649_449870_+	hypothetical protein	A0A1X9I5H8	Streptococcus_phage	2.0e-239	100.0
WP_022540567.1\|449874_450108_+	hypothetical protein	A0A1X9I5G0	Streptococcus_phage	1.6e-39	100.0
WP_041179173.1\|450808_451015_-	DUF1492 domain-containing protein	NA	NA	NA	NA
WP_004194123.1\|451812_452445_-	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	1.3e-109	97.6
451785:451802	attR	NA	NA	NA	NA
WP_004194121.1\|452501_453794_+	DEAD/DEAH box helicase	A0A1X9I5S6	Streptococcus_phage	6.3e-247	99.1

DBSCAN-SWA_4

732062 : 758602

Streptococcus_phage(85.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004194722.1\|732062_734237_-	LTA synthase family protein	W6LM83	Streptococcus_phage	1.1e-230	60.3
WP_004194720.1\|734352_735516_+	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	2.1e-140	64.7
WP_004194719.1\|735512_736187_+	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	7.7e-79	64.6
WP_004194717.1\|736190_737357_+	chorismate synthase	A0A291AU41	Pandoravirus	3.5e-39	34.9
WP_013730266.1\|737364_738468_+	prephenate dehydrogenase	NA	NA	NA	NA
WP_002938966.1\|738477_738816_+	YlbF/YmcA family competence regulator	A0A1X9I5Y8	Streptococcus_phage	1.9e-54	100.0
WP_187288283.1\|739118_740411_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	4.5e-221	97.8
WP_009909540.1\|742036_742675_-	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	4.6e-126	100.0
WP_013730269.1\|742737_745251_+	bifunctional DnaQ family exonuclease/ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	0.0e+00	99.9
WP_013730270.1\|745412_746489_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	2.1e-195	100.0
WP_009909544.1\|746553_747792_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	1.2e-223	100.0
WP_009909545.1\|747801_748587_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.6e-136	100.0
WP_013730271.1\|748609_749014_-	TetR/AcrR family transcriptional regulator	A0A1X9I6A2	Streptococcus_phage	1.1e-64	100.0
WP_013730272.1\|749140_749992_+	DegV family protein	A0A1X9I5J4	Streptococcus_phage	6.3e-155	100.0
WP_013730273.1\|750090_751350_-	PLP-dependent aminotransferase family protein	A0A1X9I5H2	Streptococcus_phage	2.7e-242	99.8
WP_024381470.1\|751472_752207_+	peroxide stress protein YaaA	A0A1X9I5I0	Streptococcus_phage	7.7e-117	96.3
WP_013730275.1\|752336_753776_+	LCP family protein	A0A1X9I5X1	Streptococcus_phage	2.2e-200	87.6
WP_013730276.1\|753791_754481_+	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	8.0e-108	92.1
WP_013730277.1\|754490_755177_+	tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	1.1e-104	92.1
WP_013730278.1\|755215_755947_+	tyrosine protein phosphatase	NA	NA	NA	NA
WP_013730279.1\|755976_757803_+	polysaccharide biosynthesis protein	A0A1V0SAI8	Catovirus	7.0e-26	27.4
WP_013730280.1\|757888_758602_+	Fic family protein	D7RWK9	Brochothrix_phage	9.2e-06	24.1

DBSCAN-SWA_5

834786 : 901476

Streptococcus_phage(78.26%)

protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013730322.1\|834786_837024_+	DNA internalization-related competence protein ComEC/Rec2	M1PSD2	Streptococcus_phage	1.4e-97	94.0
WP_002935351.1\|837025_837169_+\|transposase	transposase	NA	NA	NA	NA
WP_002935353.1\|837347_838004_+	CBS domain-containing protein	M1NSC5	Streptococcus_phage	2.1e-113	99.1
WP_002935354.1\|838097_838925_+	hypothetical protein	M1PFV6	Streptococcus_phage	6.6e-133	97.8
WP_013730324.1\|838930_840202_+	toxic anion resistance protein	M1PLC8	Streptococcus_phage	6.5e-212	99.8
WP_002935357.1\|840238_841105_-	YitT family protein	M1Q1P6	Streptococcus_phage	4.6e-153	99.7
WP_002935358.1\|841279_841918_+	dTMP kinase	M1PSC7	Streptococcus_phage	2.6e-113	98.6
WP_002935359.1\|841914_842799_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	3.6e-153	98.3
WP_002935361.1\|842818_843136_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	3.1e-54	100.0
WP_002935362.1\|843137_844001_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	2.1e-158	99.7
WP_002935363.1\|844470_845562_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	1.5e-204	98.6
WP_002935364.1\|845561_846119_+	GNAT family acetyltransferase	M1PSC3	Streptococcus_phage	4.5e-93	98.4
WP_002935365.1\|846492_847674_+	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	2.7e-220	99.7
WP_002935366.1\|847676_848183_+	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.2e-92	97.0
WP_002935368.1\|848166_848520_+	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.9e-60	100.0
WP_009909675.1\|848536_849436_-	cation transporter	M1Q1N9	Streptococcus_phage	1.3e-161	98.3
WP_002935370.1\|849735_850563_-	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	8.3e-152	99.6
WP_002935371.1\|850718_852380_+	hypothetical protein	NA	NA	NA	NA
WP_002935372.1\|852539_853928_+	amino acid permease	NA	NA	NA	NA
WP_002935373.1\|854050_854932_+	DUF975 family protein	NA	NA	NA	NA
WP_002935375.1\|855124_855961_+	DUF975 family protein	NA	NA	NA	NA
WP_002935376.1\|855978_856854_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_002935377.1\|856976_857588_+	DUF3885 domain-containing protein	NA	NA	NA	NA
WP_002935380.1\|860545_862468_+	DEAD/DEAH box helicase family protein	NA	NA	NA	NA
WP_029694137.1\|862744_863623_+	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_022540616.1\|863947_864694_+	hypothetical protein	NA	NA	NA	NA
WP_013730330.1\|867356_867926_-	ECF transporter S component	NA	NA	NA	NA
WP_002935392.1\|867912_868461_-	phosphopantothenoylcysteine decarboxylase	A0A068EHP1	Penguinpox_virus	2.8e-23	37.8
WP_022540619.1\|868453_869149_-	phosphopantothenate--cysteine ligase	NA	NA	NA	NA
WP_002935394.1\|869652_871323_+	formate--tetrahydrofolate ligase	NA	NA	NA	NA
WP_013730331.1\|871366_872176_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_002935400.1\|873950_874802_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_002935402.1\|874959_875577_+	DUF5052 family protein	A0A2K9VCV0	Lactobacillus_phage	3.8e-48	51.5
WP_013730333.1\|875577_876087_+	N-acetyltransferase	NA	NA	NA	NA
WP_002935405.1\|876076_876730_+	DNA alkylation repair protein	NA	NA	NA	NA
WP_002935406.1\|876740_877028_+	DUF1905 domain-containing protein	NA	NA	NA	NA
WP_002935416.1\|877324_878101_-	glycyl-radical enzyme activating protein	NA	NA	NA	NA
WP_002935421.1\|878232_878976_+	DeoR/GlpR transcriptional regulator	NA	NA	NA	NA
WP_002935426.1\|878988_879963_+	sugar-binding transcriptional regulator	NA	NA	NA	NA
WP_002935429.1\|880151_880475_+	PTS lactose/cellobiose transporter subunit IIA	NA	NA	NA	NA
WP_002935430.1\|880507_880813_+	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_002935431.1\|880825_882127_+	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_002935432.1\|882278_884723_+	glycyl radical protein	A0A2H4YEI2	Aeromonas_phage	4.9e-06	47.2
WP_002935438.1\|884734_885403_+	fructose-6-phosphate aldolase	E3SKN5	Synechococcus_phage	1.5e-21	31.0
WP_002935440.1\|885434_886391_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_002935441.1\|886511_887606_+	glycerol dehydrogenase	NA	NA	NA	NA
WP_002935442.1\|887774_888851_+	aspartate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_086558053.1\|890565_891858_+\|transposase	IS110-like element ISSsu7 family transposase	A0A1X9I619	Streptococcus_phage	1.4e-225	100.0
WP_002935451.1\|892072_893863_-	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	0.0e+00	100.0
WP_002935455.1\|894029_894368_+	hypothetical protein	NA	NA	NA	NA
WP_002935458.1\|894552_895920_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_009909707.1\|896209_898489_+	DNA helicase PcrA	A7KV33	Bacillus_phage	1.2e-128	41.0
WP_009909709.1\|898930_899671_+	hypothetical protein	NA	NA	NA	NA
WP_013730335.1\|899949_900633_+	noncanonical pyrimidine nucleotidase, YjjG family	NA	NA	NA	NA
WP_013730336.1\|900711_901476_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_6

1238423 : 1288306

Streptococcus_phage(22.22%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_162467394.1\|1238423_1239716_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	6.8e-217	95.8
WP_013730412.1\|1239918_1243413_-	YSIRK-type signal peptide-containing protein	NA	NA	NA	NA
WP_009910076.1\|1243509_1243818_-	preprotein translocase subunit YajC	NA	NA	NA	NA
WP_002936073.1\|1243824_1244640_-	PTS mannose/fructose/sorbose transporter family subunit IID	NA	NA	NA	NA
WP_002936077.1\|1244626_1245403_-	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	NA	NA	NA	NA
WP_002936080.1\|1245422_1245914_-	PTS system mannose/fructose/N-acetylgalactosamine-transporter subunit IIB	NA	NA	NA	NA
WP_013730413.1\|1245923_1247114_-	glycoside hydrolase family 88 protein	NA	NA	NA	NA
WP_002936085.1\|1247125_1247560_-	PTS sugar transporter subunit IIA	NA	NA	NA	NA
WP_022540650.1\|1247845_1248487_-	bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase	NA	NA	NA	NA
WP_002936090.1\|1248497_1249499_-	sugar kinase	NA	NA	NA	NA
WP_002936092.1\|1249515_1250157_-	RpiB/LacA/LacB family sugar-phosphate isomerase	NA	NA	NA	NA
WP_002936093.1\|1250208_1251024_-	gluconate 5-dehydrogenase	NA	NA	NA	NA
WP_002936094.1\|1251934_1253029_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_002936095.1\|1253136_1253811_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_002936096.1\|1253820_1254138_-	hypothetical protein	NA	NA	NA	NA
WP_012775187.1\|1254147_1254837_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_013730414.1\|1255089_1255848_-	DUF3169 family protein	NA	NA	NA	NA
WP_009910096.1\|1255844_1256060_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_013730415.1\|1256072_1256639_-	DUF3267 domain-containing protein	NA	NA	NA	NA
WP_013730417.1\|1256785_1256983_-	hypothetical protein	NA	NA	NA	NA
WP_099425949.1\|1257099_1257946_-\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	6.8e-08	25.1
WP_002938097.1\|1258083_1258536_-	cytidine deaminase	NA	NA	NA	NA
WP_022540652.1\|1258605_1261230_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	1.5e-61	34.2
WP_002938099.1\|1261509_1261995_-	LURP-one-related family protein	NA	NA	NA	NA
WP_002938100.1\|1262259_1263261_-	peptidylprolyl isomerase PrsA	NA	NA	NA	NA
WP_009910106.1\|1263321_1264041_-	O-methyltransferase	NA	NA	NA	NA
WP_002938103.1\|1264115_1264664_-	hypothetical protein	NA	NA	NA	NA
WP_002938105.1\|1264679_1265120_-	hypothetical protein	NA	NA	NA	NA
WP_009910108.1\|1265121_1266924_-	oligoendopeptidase F	NA	NA	NA	NA
WP_002938107.1\|1267155_1268097_-	competence protein CoiA	NA	NA	NA	NA
WP_074390814.1\|1268160_1270218_-\|tRNA	methionine--tRNA ligase	A0A1V0SEZ7	Hokovirus	5.8e-85	31.1
WP_002938116.1\|1270317_1270911_+	DUF1361 domain-containing protein	NA	NA	NA	NA
WP_002938119.1\|1271211_1272249_+	3-deoxy-7-phosphoheptulonate synthase	S4W5F1	Pandoravirus	2.2e-45	34.3
WP_002938121.1\|1272258_1273284_+	3-deoxy-7-phosphoheptulonate synthase	S4W5F1	Pandoravirus	3.2e-44	35.2
WP_002938123.1\|1273329_1274199_+	shikimate dehydrogenase	NA	NA	NA	NA
WP_002938125.1\|1274211_1275279_+	3-dehydroquinate synthase	NA	NA	NA	NA
WP_002938126.1\|1275482_1276283_-	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	9.0e-10	23.8
WP_013730419.1\|1276292_1277186_-	ABC transporter permease	NA	NA	NA	NA
WP_013730420.1\|1277240_1278215_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013730421.1\|1278238_1279198_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_013730422.1\|1279938_1280940_-	tagatose-bisphosphate aldolase	NA	NA	NA	NA
WP_013730423.1\|1280963_1282109_-	N-acetylglucosamine-6-phosphate deacetylase	NA	NA	NA	NA
WP_024390310.1\|1282615_1283446_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_009909533.1\|1283472_1284105_-	amino acid ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	6.6e-32	38.9
WP_013730426.1\|1284114_1284756_-	amino acid ABC transporter permease	NA	NA	NA	NA
WP_013730428.1\|1287049_1288306_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	7.5e-128	56.4

DBSCAN-SWA_7

2013265 : 2032613

Streptococcus_phage(66.67%)

transposase,integrase

attL 2018297:2018354|attR 2031070:2031127

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002938187.1\|2013265_2014102_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	1.3e-22	32.9
WP_013730677.1\|2014098_2014638_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_002939074.1\|2014647_2015505_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_002939071.1\|2015586_2016870_-	insulinase family protein	NA	NA	NA	NA
WP_009911054.1\|2016866_2018120_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	4.2e-232	99.0
2018297:2018354	attL	NA	NA	NA	NA
WP_013730680.1\|2018903_2019452_-	hypothetical protein	A0A1X9I5U4	Streptococcus_phage	4.7e-50	58.1
WP_013730681.1\|2019529_2019988_-	hypothetical protein	A0A1X9I5V5	Streptococcus_phage	7.6e-22	42.0
WP_013730682.1\|2020000_2020816_-	DnaD domain protein	A0A2I6QQV2	Streptococcus_phage	2.0e-81	66.0
WP_013730683.1\|2020802_2021087_-	hypothetical protein	A0A1X9I5U9	Streptococcus_phage	8.9e-37	83.9
WP_013730684.1\|2021076_2021415_-	hypothetical protein	A0A1X9I5Z6	Streptococcus_phage	5.1e-47	97.8
WP_013730685.1\|2021411_2021561_-	hypothetical protein	A0A1X9I6A8	Streptococcus_phage	2.4e-17	89.8
WP_013730686.1\|2021572_2021776_-	hypothetical protein	A0A1X9I5T6	Streptococcus_phage	7.2e-25	79.1
WP_013730687.1\|2021763_2022153_-	hypothetical protein	NA	NA	NA	NA
WP_013730688.1\|2022591_2023218_-	Rha family transcriptional regulator	A0A192Y918	Salmonella_phage	9.5e-15	32.8
WP_013730689.1\|2023230_2023977_-	Bro-N domain-containing protein	A0A0A7RW33	Clostridium_phage	2.1e-24	50.7
WP_013730690.1\|2023995_2024223_-	helix-turn-helix transcriptional regulator	Q38329	Lactococcus_phage	2.8e-09	51.6
WP_013730691.1\|2024376_2025090_+	helix-turn-helix transcriptional regulator	Q708R9	Streptococcus_phage	3.7e-15	50.6
WP_013730692.1\|2025453_2026284_+	KilA-N domain-containing protein	Q4ZC41	Staphylococcus_virus	1.2e-89	62.1
WP_013730693.1\|2026448_2027621_+\|integrase	site-specific integrase	A0A1X9I5Y5	Streptococcus_phage	3.1e-216	96.9
WP_002936175.1\|2027758_2028142_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	4.6e-36	94.5
WP_022540734.1\|2028144_2029239_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_162096930.1\|2029678_2030971_-\|transposase	IS110-like element ISSsu7 family transposase	A0A1X9I619	Streptococcus_phage	8.8e-225	99.8
WP_014637236.1\|2031131_2032613_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	3.6e-97	41.9
2031070:2031127	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022516

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection