CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022524	Bacillus infantis NRRL B-14911, complete genome	11 crisprs	RT,DinG,csa3,WYL,DEDDh,cas3	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022524_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_1

761149-761248

Orphan

Consensus_repeat	Method
GCTTTTTTTGTTTGGGCCAGGGG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NC_022524_1

>merge|NC_022524|1|761149-761248|CRISPRCasFinder
GCTTTTTTTGTTTGGGCCAGGGGGTCTGTCCCCCCGGCTTTCTTGTAGCGAAGAGCCAAGGGGACAGACCCCCTGGCTCTTTTTTTGTTTGGGCCAGGGG

>NC_022524|1|1|761149-761248|CRISPRCasFinder
GCTTTTTTTGTTTGGGCCAGGGG	GTCTGTCCCCCCGGCTTTCTTGTAGCGAAGAGCCAAGGGGACAGACCCCCTGGC
TCTTTTTTTGTTTGGGCCAGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_022543414.1\|753245_753695_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009792014.1\|765448_765988_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009792007.1\|771049_772006_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|226964
NC_022524.1\|WP_035401611.1\|756382_756871_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|379804
NC_022524.1\|WP_009792013.1\|765960_766215_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_022543417.1\|763137_765180_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224684
NC_022524.1\|WP_009792008.1\|770106_771063_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226965
NC_022524.1\|WP_022543415.1\|754533_756231_-\|M3-family-oligoendopeptidase	unknown	unknown	gnl\|CDD\|341069
NC_022524.1\|WP_035401607.1\|766429_767161_+\|plasmid-pRiA4b-ORF-3-family-protein	unknown	unknown	gnl\|CDD\|377943
NC_022524.1\|WP_009792028.1\|750406_750949_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009792024.1\|753792_754449_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153223
NC_022524.1\|WP_009792021.1\|757032_758259_+\|DUF819-domain-containing-protein	unknown	unknown	gnl\|CDD\|227792
NC_022524.1\|WP_009792016.1\|762359_762989_+\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153234
NC_022524.1\|WP_156916992.1\|751870_753181_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236901
NC_022524.1\|WP_035401604.1\|769104_769866_+\|transposase	unknown	unknown	gnl\|CDD\|376616
NC_022524.1\|WP_022543418.1\|767491_768823_+\|fructotransferase	unknown	unknown	gnl\|CDD\|376254
NC_022524.1\|WP_156917040.1\|751246_751393_-\|glycine-zipper-family-protein	unknown	unknown	unknown
NC_022524.1\|WP_009792020.1\|758665_759520_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_022543416.1\|759831_761127_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143454
NC_022524.1\|WP_009792017.1\|761322_762285_+\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_035401607.1\|766429_767161_+\|plasmid-pRiA4b-ORF-3-family-protein	gnl\|CDD\|377943	pfam07929, PRiA4_ORF3, Plasmid pRiA4b ORF-3-like protein. Members of this family are similar to the protein product of ORF-3 found on plasmid pRiA4 in the bacterium Agrobacterium rhizogenes. This plasmid is responsible for tumorigenesis at wound sites of plants infected by this bacterium, but the ORF-3 product does not seem to be involved in the pathogenetic process. Other proteins found in this family are annotated as being putative TnpR resolvases, but no further evidence was found to back this. Moreover, another member of this family is described as a probable lexA repressor and in fact carries a LexA DNA binding domain (pfam01726), but no references were found to expand on this.	2.17146e-47
NC_022524.1\|WP_009792007.1\|771049_772006_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|226964	COG4605, CeuC, ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism].	1.07285e-115
NC_022524.1\|WP_022543418.1\|767491_768823_+\|fructotransferase	gnl\|CDD\|376254	pfam18835, Beta_helix_2, Beta helix repeat of Inulin fructotransferase. This region contains a right-handed parallel beta helix repeat unit found in Inulin fructotransferase. This Pfam entry includes sequences not found by pfam13229.	4.67227e-08
NC_022524.1\|WP_009792008.1\|770106_771063_+\|ABC-transporter-permease	gnl\|CDD\|226965	COG4606, CeuB, ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism].	9.67215e-139
NC_022524.1\|WP_022543415.1\|754533_756231_-\|M3-family-oligoendopeptidase	gnl\|CDD\|341069	cd09606, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3 oligopeptidase F (oligendopeptidase) is mostly bacterial and includes oligoendopeptidase F from Geobacillus stearothermophilus. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids and may cleave proteins at Leu-Gly. The PepF gene is duplicated in Lactococcus lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid.	0
NC_022524.1\|WP_035401611.1\|756382_756871_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|379804	pfam16242, Pyrid_ox_like, Pyridoxamine 5'-phosphate oxidase like. This domain, approximately 140 residues in length, is mainly found in general stress proteins in various Xanthomonas species. It is composed of a six-stranded antiparallel beta-barrel flanked by five alpha-helices and can bind to FMN and FAD, suggesting that it may help the bacteria to react against the oxidative stress induced by the defense mechanisms of the plant.	1.05519e-59
NC_022524.1\|WP_035401604.1\|769104_769866_+\|transposase	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	3.91815e-18
NC_022524.1\|WP_009792021.1\|757032_758259_+\|DUF819-domain-containing-protein	gnl\|CDD\|227792	COG5505, COG5505, Predicted integral membrane protein [Function unknown].	1.77811e-103
NC_022524.1\|WP_009792016.1\|762359_762989_+\|glutamine-amidotransferase	gnl\|CDD\|153234	cd03140, GATase1_PfpI_3, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	8.52032e-74
NC_022524.1\|WP_156916992.1\|751870_753181_+\|hypothetical-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	5.10556e-50
NC_022524.1\|WP_022543417.1\|763137_765180_-\|S9-family-peptidase	gnl\|CDD\|224684	COG1770, PtrB, Protease II [Amino acid transport and metabolism].	0
NC_022524.1\|WP_009792024.1\|753792_754449_-\|hypothetical-protein	gnl\|CDD\|153223	cd03129, GAT1_Peptidase_E_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins. Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins. This group contains proteins similar to the aspartyl dipeptidases Salmonella typhimurium peptidase E and Xenopus laevis peptidase E and, extracellular cyanophycinases from Pseudomonas anguilliseptica BI (CphE) and Synechocystis sp. PCC 6803 CphB. In bacteria peptidase E is believed to play a role in degrading peptides generated by intracellular protein breakdown or imported into the cell as nutrient sources. Peptidase E uniquely hydrolyses only Asp-X dipeptides (where X is any amino acid), and one tripeptide Asp-Gly-Gly. Cyanophycinases are intracellular exopeptidases which hydrolyze the polymer cyanophycin (multi L-arginyl-poly-L-aspartic acid) to the dipeptide beta-Asp-Arg. Peptidase E and cyanophycinases are thought to have a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad typical of GATase1 domains by having a Ser in place of the reactive Cys at the nucleophile elbow. Xenopus peptidase E is developmentally regulated in response to thyroid hormone and, it is thought to play a role in apoptosis during tail reabsorption.	6.52932e-11
NC_022524.1\|WP_022543416.1\|759831_761127_+\|aldehyde-dehydrogenase	gnl\|CDD\|143454	cd07136, ALDH_YwdH-P39616, Bacillus subtilis aldehyde dehydrogenase ywdH-like. Uncharacterized Bacillus subtilis ywdH aldehyde dehydrogenase (locus P39616) most closely related to the ALDHs and fatty ALDHs of families 3 and 14, and similar sequences, are included in this CD.	0
NC_022524.1\|WP_009792017.1\|761322_762285_+\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.54085e-48

>NC_022524.1|WP_022543416.1|759831_761127_+|aldehyde-dehydrogenase
MENYQELLNKQRAYFRSGETKSVSFRLRTLNTLKSLVLKHEQDIFDAVKQDLNKSELEAKRAEVGLVISEIDYMVENLEEWAATKEVPTPASHEGARSFVQPEPYGSALVIAPWNYPFQLAVTPLVGAIAAGNTAVLKPSELTPKTSALLSAMINDNFPEEYLRVVEGEVETSTALLKEDFDYIFFTGSTGVGKIVAEAAAKHLTPTTLELGGKSPTIVHKDADLDEAAQRIARGKFANAGQTCVAPDYLLVHSSVKDELMNKFKEVISAAFGENIVENPNFGHVVSERHFNRLVGFLDNGSIVAGGQHNRDELIIEPTILDNISWDDSVMQDEIFGPILPVMTYDNLDEIIEPIMNRPKPLALYLFSNDESVQDQILGTISFGGGSINDTINHMTSHYLPFGGVGASGMGAYHGKASFDTFTHFKSVLKR
>NC_022524.1|WP_009792020.1|758665_759520_+|hypothetical-protein
MNLINKKVTHKLFGMGSIVEHNDTSIVIHFASEKKKFVFPDVFGEHLILHDEMISKSLDAIIQNKENERREEDRKKEEEKNRYRKSQELRLGYEKLMKNHKLHPESQMVFWCDAEEQDRSFTEWKVFSGVIKSGNNKGKPNKPSRLHQNSAVLLTAVDPSKPEKDRRILGVYMVKEKFIGKLCEDGNIPAHSTYRLQLTEEESEQMPFWDYYVNEKSPQKMTWNTGKYRYFENSWMAQTLRDIVALKSDPKEREHAQQFFEHFCKMNQIIEQDLPKPNGALMRS
>NC_022524.1|WP_009792021.1|757032_758259_+|DUF819-domain-containing-protein
MEDTLIKADDYVTLWGIIVVWASASIILEQRYSWAAKISGAIIALIGAIILSNTGIIPTASPVYDAIWTFIIPLAIPLLLFHVNFKRIWKESGRLLIIFLISSIGTVAGVMISFFLLKDHIPVLDKLGAMLSASYIGGGVNFAAMAAKFEAPGEMVSSAVVADNLMMAIYFIVLMMIPAMGFFRRRFRAPHVEKVESGGVREEGKTLAESFWERKDISLKDIALSVGTAFLLVVVSFKIAAFMDGLIPSGEDTSFFLNLLNGLFGDNYLMLTTLTFLALALFPRYFESINGSQEIGTFLIYLFFVVIGIPASIPLIVQNAPLLLVFVFIIVVVNLAVSLTAGKLLKYNLEEILLASNANVGGPTTAAAMAIAKGWKDLIGPILVVGTLGYIIGNYVGTTLGLWFSGFM
>NC_022524.1|WP_035401611.1|756382_756871_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MLNMLKQEEMETLRELIKDVDTAMLTTVSEEGLVSRPMKTQEVEFDGDLWFFTKKETDKYEEILHDKDVNVAYAGKSYVSVRGRAEIVEDIGKKKELWSKMYEKIMQTSYDDPSVVLIKVKAEAAEYWESGSFTKKAVFMLKRITGQDAEEAGVNETVQMEK
>NC_022524.1|WP_022543415.1|754533_756231_-|M3-family-oligoendopeptidase
MTQEVKSNYYKELIDLQDAEGVEAQLQALLEVPIDSVSDLENWLKDEKELGIKIDEAMTGHQVDFYRNTEDADIKSTYLHDQQVIQPLLMKYEAKMNEKFCESPYAAQLDDKRYGLMRRVRESKVKLFREENIPLMVKEQELSTKYSEIIAGLTVEWDGEEKPYPFIQSQLDNLDRSVREKAYYAMLEAHRQIKPDMDSIMDELVQLRHQIALNAGFENYRDYMFVVKNREYTIQDCYDFHENVEKHIIPAWNRLAEVFKSKLGVDAYRPWDNTAKLMKNPPYTEVSDLMDGVSEMLGKTDPYFADRFDYMRENGLLDLGDRKGKSPGGFCTTLSVSGDTFVFANFSPSFFSLIALIHEMGHAVNGYLEFAEHGPLEEHQHRMEVAELYSHGMELLLLDKLDRFYPEEEDFKSAQREELRRAFTMLYGPLSGDLFQHWMYTNPNHTAKERDEKYFEIAKRYGLSPVDTSGLEDVMGILWADTLHYFQVPFYNIEYSISMLGSLQILENYHNNPEQAVELFKKGASADYNQSIADIYKETGVSFDFSESAVKRMGEFLEKVIQDIH
>NC_022524.1|WP_009792024.1|753792_754449_-|hypothetical-protein
MKTHYYLGWFNKHFPEKLSKLLQEDIIDRKSLVMISSSPSIYEEMGAAERSWLDQAGIVFDEYHLINYRVPKKEAHTLISNASVIFLLGGNTVEQNKFLAGYELSDPITKSRATVMGASAGAINMSAKWLCSKNLGYNVEVSTLYDGIGLGDFAVLSHFDLEHNLALVQNELSPLSEEMNIYASNKDCAVRVKGDKIDILGTVYLISRSKIERLDETL
>NC_022524.1|WP_022543414.1|753245_753695_-|hypothetical-protein
MRFLSFISCLLFVSVLAGCIGEDYDFSPPTVSLFNPDDITHETALEEANIEWDFDEQYNKKTDDVQALAKKQEVMHFNSGQKVQYILEAGHFDSDGVSVSVWKNDSETKLKLEKGQSFYLPEETGEYVIVFDLDTDKGAAQYVGNIVIE
>NC_022524.1|WP_156916992.1|751870_753181_+|hypothetical-protein
MCEFLLKYKYIEQKANGAQMSIVKDFLLQLTLMVIPIFSYFTFILEKVKEERSIKILMTLLWGVSILLCMSFPVEYAEAARLDIRFIPLLFGTLYLGVWSGVFLTALIILYRLSFGISMGFLTTVMVSIITLPVILSVQRLFLRVNKDRRIIISTGLSFFYCLCGMAVSGIMNGFSTNVLKVQGIHLLFTVAVTWFCTVLVEKIRENHQLRLKVQDSEKFRVISELTGVFAHEIRNPMQVTRGFLQLLDDPDLPNPKREYIKLSIEELDRANEIINDFLTFGKPSSSTDRAVNVSEHLKRTAALIQTFSVNQQVEFQTDIQDDCWIKADPQKLNQSLLNILKNAVESMPNGGTMSLSCHQTADRHIRIAVKDQGIGMNPKQVQRLGSPYYSLKEKGTGLGMMVSYQIIHSFKGRIRVESEEGVGTEFIIDFPGIEP
>NC_022524.1|WP_156917040.1|751246_751393_-|glycine-zipper-family-protein
MSIGISIGTAIGLVVFDNLVLGLPLGMCIGIAIGTGLDEDAKKKGLTL
>NC_022524.1|WP_009792028.1|750406_750949_+|hypothetical-protein
MKPSYEDVKEARELLKEVAFKHWIQDDLFTWKWWVLLAATIIPWILWLSFRDKKRTFEILSYGLIWAAAASLFDVIGGELILWGYPDKLLPMVPPLFPADITVIPVLFMFIYQLSKRYYSYFILSVLGSALFAYVFEPLFVKGGMFILHNWTHTKSFSGFFLLSQIVYVIIARLKSSIQP
>NC_022524.1|WP_009792017.1|761322_762285_+|YafY-family-transcriptional-regulator
MAKMDQMMQILWMLSSGRKATAKQMAEKLEVNIRTVYRYIDALCASGVPIIAEAGHHGGYTLLHQFVESPLLFSAEEQTALLQAAALAKETGYFSGELLDKAASKLSMYSTPEQESMVRRRVEGLDVIGSAAGLPEDAILRELEHGVINQVSMEIDYYTVREDQPKRRKIDPYGIIYWNGRWYVAAFCHLRNEIRSFRVDRIAGMAEIGTSFNRPADFSASGFFMKNLLPEKEQTQEFVPFVISGRTGALDDLCRHWFLGHHLAERTSERAVFILEKEALHTYVAHLLLPYGKSLKVLEPDSMKKKLVEVLYELADHYQK
>NC_022524.1|WP_009792016.1|762359_762989_+|glutamine-amidotransferase
MHKRKAYLYVFDTMSDWEAGYLIAELNSGRYFRRGVAPIEVMTVGADKNPVKTMGGVTIQPDLSMEEFSLGSQDILILPGGDTWLEPIHESILEEASNGLQRGTIVAAICGATMGLANKGLLDTRRHTSNDPGYLKAVCPLYAGESLYQFEPAVADGNLVTASGIAPLEFASEVLKMLDVCKPETLQAWFKLNKTHEAGYFYELMNTLQ
>NC_022524.1|WP_022543417.1|763137_765180_-|S9-family-peptidase
MKPPIAKRIPHPHNLHGDVREDDYYWLRDRNNPEVITYLEEENRYYDEIMRPLEEQTEQLYQSMVDRVPDSEVKVPVQHGPYFYYSFLDKDKQYPIYARKKAANREQLPEAAEEIILDLNKLTAEGDYLSVTLQRISTDHNRLAYLENRDGTDRYTIYVKDLETGELLPDKVPNVFIHGSMELSECGEYIFYITVDESQRPYQLWRHRLGSENSSDELLYEEKDITFSLYVSKSQSGKYIFAHSRSKTTSEVRLLDAASPLTPLQLVDERREGIEYSVEHWEDDLLILTNEDALNFQLLRCPADDLSARMKVVGHCEDRYLQAMYPYQDTLLLFGRENGLTQIWVLHDGEMARIEWDEPLFTVSVLPGQSYETAEALLQFESLVTPKTTYGLNLLTGERNCLQVAPVSGEYDPSLFQQEQLWASAEDGVQVPLNVVYQEGALDNGPAPLILYAYGSYGANSDPRFDPYRLPLLEKGVIYVTAQVRGGSEMGRNWYEDGKMQNKRNTFTDFIAAGKFLIEKGYTSSSQMAAYGGSAGGLLVGAVANMAGDLFQVAVPAVPFVDVVTTMLDATIPLTTLEWDEWGNPENKEDYFYMKSYSPYDNVEAKNYPHMYITTGLNDPRVAYWEPAKWAARLRALKTDNNTLVLKTNMGAGHFGASGRFNHLKETAACYAFILDKIRP
>NC_022524.1|WP_009792014.1|765448_765988_+|hypothetical-protein
MLLDAATNKPVVFYFREVGKEEIKGNRYLSDYGWEFNWLHPISHGFRVFGLVTNKNPDFVEGLIALKENPDEDFLCVDVDIIESAPQNKKFIKGVLNEERSNINVGRILIAFACWYSIDKGYDGYVGLTSKSSKYPFYMSMGARQTFGQYIMFDDIAASRLVKQYFPGGVLWWQDSNSN
>NC_022524.1|WP_009792013.1|765960_766215_+|hypothetical-protein
MVAGLKFKLRHIKRTPDVHTIARSDIMRRDIDKFDNAFPDGVFAFPASTESPKVKIRALDKYCKEHGVEPKDLTEDEMKPFLVY
>NC_022524.1|WP_035401607.1|766429_767161_+|plasmid-pRiA4b-ORF-3-family-protein
MKSYILRIELEGSNPLIWRKVIMPAGATYKRLHDVIQNVTNFRSGYPYDGYHLFEFDLIEDQRIVTDNEEAYLEHQHFKKNKAMYAERLKSMPVEMLDFEKNYQERLKIEVRKPSGLKIDDYLEKYKEIKYSYDFGDGWRFNVKLEQTIDDYYFGFPTLLDGAETAPPEDVGGLPGFYEFLEVYRDEKHPEHEDMKVWAETMYFREYDPDSLNSRLKGLHYKKTEWDKINHERYEVIEDKYRK
>NC_022524.1|WP_022543418.1|767491_768823_+|fructotransferase
MASKNYYDVTEWPVGNPYEDIGGVINSIIADVKSRQTDNDVNKGGKPGAVIYIPPGDYRLASQVVIDISFLKIMGSGHGFTSSSIRFNTPENEWADLHELWPGGSRILVDIPVGANEEEFKGAAFYVERSGNPRISSVEFADFCIDGLHFIDDGSGEANPENTYTNGKTGIYVAGACDSFRITGMGLVYLEHGLTIYHADALTIHDNFIAECGSCIELRGWGQASKITDNLIGAGFKGYSIYAQNFGGLLVTANNVFPRGASSIYFDGVTRSSITNNRLHSFYPGMVVFKENCSENLISSNHFLRDHEPWTPFVGKDNGLDDLYGLLCINGNHNSVMANHFSEVINIQHIKPAGATPVIIRIVSGSGNYISNNHVVATGVDAKSSDSCFSAQVEALLTTEASEPLTVTTVLVEKESSQNTILDSGREGQVVLDKNVNAFRATP
>NC_022524.1|WP_035401604.1|769104_769866_+|transposase
MPRQARKKSMTGIYHVMLRGINKQTIFEDDEDRRRFIYTVLKYKKKYDFDLFAYCLMDNHVHLLLKEKEITLSDIIKNLSSSYVYWYNTKYDRSGHLFQGRFRSENVETTPYFLKVIRYIHQNPLKAGLARTAFSSKWTSINEYTSPSSALNTAAALKLFSQNKDESITLFKEYMNALNQDECLEDNPRSRKTDEQLISYIREIGIHHTSMLQQMNKPQRNTILRELRKLEGVSDRQLSRVTGVSRSIIQRLG
>NC_022524.1|WP_009792008.1|770106_771063_+|ABC-transporter-permease
MKLWVLAIAAFVLSGVSLFIGAIDIGIGDLLDWESDEAQIFLISRVPRLMAIILAGAGMSIAGLIMQSLSRNKFVSPTTAGTLDAAKLGILISMLFFTNVTYTQQVLFSFAFALAGTFVFMQILDRVKFKDVIFVPLIGIMYGNILSSITTFFAYEADLLQNISSWLMGSFTLVISGRYELLYISVPAVILAYIYANKFTVAGMGEDFAKNLGLSYKVVLNLGLILVAIISTTVVLTVGVIPFLGLIVPNIVSLYLGDNLRKSIPHTALLGIVFLLICDIIGRIVIHPYEIPVNVTVAVIGSAIFLIMLFRGRAYAKK
>NC_022524.1|WP_009792007.1|771049_772006_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MRKNSTKLIFLAVLAIVSILFYAFYDIKGGFDYAFPRRMMKIAAMVITGTAIAYSTVVFQTITHNRILTPSMMGLGSMYEVVQTLIYFFGGSMSVWVLNKYLNFGTAIFAMVLFALLLYRFLFRADKYPIYLLLLIGMIIGTLLGSLVTFLQVIIDPVEYLSLQSRLFATFTNVKSDLLMIAAGILLVAFIYGFRIMGQLDVMSLGRDNAMNLGINYDRMVMNILILSSVLIATSTALVGPITFFGLIVANLSYQFLVTYKHSVLILGASLISIIALVGGQFLVEHIFELRTTLSVIINFVGGIYFIYLLLKESRSAG

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Crispr_ID: NC_022524_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_2

2046775-2046849

Orphan

Consensus_repeat	Method
AATAAGCGGAGATTTTCCGGTTAA	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NC_022524_2

>merge|NC_022524|2|2046775-2046849|CRISPRCasFinder
AATAAGCGGAGATTTTCCGGTTAAATTGATAATAGGGCTCGAAAGGGTATAAATAAGCGGAGATTTTCCGGTTAA

>NC_022524|2|2|2046775-2046849|CRISPRCasFinder
AATAAGCGGAGATTTTCCGGTTAA	ATTGATAATAGGGCTCGAAAGGGTATA
AATAAGCGGAGATTTTCCGGTTAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_009791630.1\|2054924_2055140_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224393
NC_022524.1\|WP_009791625.1\|2050639_2050879_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_022543788.1\|2051001_2051964_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NC_022524.1\|WP_022543790.1\|2053205_2054390_+\|serine-tRNA(Ala)-deacylase-AlaX	unknown	unknown	gnl\|CDD\|237551
NC_022524.1\|WP_022543786.1\|2037272_2038697_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|236901
NC_022524.1\|WP_009791620.1\|2044632_2045679_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|238527
NC_022524.1\|WP_009791623.1\|2048219_2050190_+\|LTA-synthase-family-protein	unknown	unknown	gnl\|CDD\|224287
NC_022524.1\|WP_009791077.1\|2036066_2037116_-\|M42-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349907
NC_022524.1\|WP_009791631.1\|2055144_2055519_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_050767245.1\|2035500_2036031_+\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|350620
NC_022524.1\|WP_022543787.1\|2042050_2044342_+\|DEAD/DEAH-box-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|224120
NC_022524.1\|WP_009791081.1\|2041093_2041285_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009791622.1\|2047235_2047850_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225239
NC_022524.1\|WP_009791082.1\|2041500_2041947_+\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NC_022524.1\|WP_022543789.1\|2052055_2052427_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NC_022524.1\|WP_009791621.1\|2045693_2046659_+\|alpha-L-glutamate-ligase	unknown	unknown	gnl\|CDD\|273261
NC_022524.1\|WP_009791080.1\|2040011_2041046_+\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|225803
NC_022524.1\|WP_009791624.1\|2050323_2050557_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009791628.1\|2052448_2053171_+\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393
NC_022524.1\|WP_009791079.1\|2038760_2039846_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_009791630.1\|2054924_2055140_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	5.72353e-27
NC_022524.1\|WP_022543788.1\|2051001_2051964_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	3.43897e-24
NC_022524.1\|WP_022543790.1\|2053205_2054390_+\|serine-tRNA(Ala)-deacylase-AlaX	gnl\|CDD\|237551	PRK13902, alaS, alanyl-tRNA synthetase; Provisional.	3.40632e-75
NC_022524.1\|WP_022543786.1\|2037272_2038697_+\|PAS-domain-S-box-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	1.08995e-64
NC_022524.1\|WP_009791620.1\|2044632_2045679_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|238527	cd01094, Alkanesulfonate_monoxygenase, Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).	9.68114e-91
NC_022524.1\|WP_009791082.1\|2041500_2041947_+\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	6.36625e-42
NC_022524.1\|WP_009791077.1\|2036066_2037116_-\|M42-family-metallopeptidase	gnl\|CDD\|349907	cd05657, M42_glucanase_like, M42 Peptidase, endoglucanase-like subfamily. Peptidase M42 family, glucanase (endo-1,4-beta-glucanase or endoglucanase)-like subfamily. Proteins in this subfamily are co-catalytic metallopeptidases, found in archaea and bacteria. They show similarity to cellulase and endo-1,4-beta-glucanase (endoglucanase) which typically bind two zinc or cobalt atoms. Some of the enzymes exhibit typical aminopeptidase specificity, whereas others are also capable of N-terminal deblocking activity, i.e. hydrolyzing acylated N-terminal residues. Many of these enzymes are assembled either as tetrahedral dodecamers or as octahedral tetracosameric structures, with the active site located on the inside such that substrate sizes are limited, indicating function as possible peptide scavengers.	0
NC_022524.1\|WP_050767245.1\|2035500_2036031_+\|M15-family-metallopeptidase	gnl\|CDD\|350620	cd14845, L-Ala-D-Glu_peptidase_like, L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase. This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.	2.19706e-49
NC_022524.1\|WP_022543787.1\|2042050_2044342_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	3.26475e-73
NC_022524.1\|WP_009791622.1\|2047235_2047850_-\|hypothetical-protein	gnl\|CDD\|225239	COG2364, COG2364, Predicted membrane protein [Function unknown].	1.17024e-31
NC_022524.1\|WP_009791623.1\|2048219_2050190_+\|LTA-synthase-family-protein	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	0
NC_022524.1\|WP_022543789.1\|2052055_2052427_+\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	6.29244e-10
NC_022524.1\|WP_009791621.1\|2045693_2046659_+\|alpha-L-glutamate-ligase	gnl\|CDD\|273261	TIGR00768, Tetrahydromethanopterin:alpha-L-glutamate_ligase, alpha-L-glutamate ligase, RimK family. This family, related to bacterial glutathione synthetases, contains at least three different alpha-L-glutamate ligases. One is RimK, as in E. coli, which adds additional Glu residues to the native Glu-Glu C-terminus of ribosomal protein S6, but not to Lys-Glu mutants. Most species with a member of this subfamily lack an S6 homolog ending in Glu-Glu, however. Members in Methanococcus jannaschii act instead as a tetrahydromethanopterin:alpha-l-glutamate ligase (MJ0620) and a gamma-F420-2:alpha-l-glutamate ligase (MJ1001).	3.23321e-11
NC_022524.1\|WP_009791080.1\|2040011_2041046_+\|mechanosensitive-ion-channel	gnl\|CDD\|225803	COG3264, COG3264, Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane].	5.07059e-37
NC_022524.1\|WP_009791628.1\|2052448_2053171_+\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	1.99856e-06
NC_022524.1\|WP_009791079.1\|2038760_2039846_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	4.3583e-57

>NC_022524.1|WP_009791621.1|2045693_2046659_+|alpha-L-glutamate-ligase
MSKIHIIHENSEWTAHLTKRLEELGLPYEEWFLNEGIVDLTSAPPEGIFYSRMSASSHTRGNRFAPELTESVLSWLEQHGRTVFNGSRALRLEVSKVNQYTALNAAGIATPKTIAAVGKNQILEAAVKLDSAPFITKHNRAGKGLGVQLFHSLDALREYVEGPNFEEPVDGITLIQEYIESPESYITRCEFVGGKFVYAVQVDTSEGFELCPADACQIGDLFCPVGEEVEEKPKFKIIEGFNDPIIEKYERFLKENGIQIAGIEFIKNANGDIYTYDVNTNTNYNSDAEAKAGKYGMLEAAKFLGAELEKEQAKVREYSRV
>NC_022524.1|WP_009791620.1|2044632_2045679_+|LLM-class-flavin-dependent-oxidoreductase
MKYGFWLPIFGGWLRNVEDEKMPPTFSYAKEVIQAAEKWGYDTTLIAELYLNDIKGPEQDSLEAWSTAAALAAVTEKIEIMTAVRPGFHNPAVTAKMASNIDHISNGRFTLNVVSAWWEEEARQYAGIFTEHDERYDRTEEFVKVMKGLWEEETFNFDGSYYSIKNAHLSPKPVQRPNPILYAGGESPRGKEAIVNHCDAYVMHGGTVEEVKTKIDDMRARRQESGNEPFKSFGMAAYIVCRDTEEEAQEELARITNVKESSGYAGYKDFVGKSQLEQQVKLYDYSVSNRGLRPNLIGTPEQIAEQIIAYEEAGVDLLLLQFSPQLEEMQRFSEKVMPLVEAKRKILK
>NC_022524.1|WP_022543787.1|2042050_2044342_+|DEAD/DEAH-box-helicase
MTKSWRISARSLAEYVYRSGSIESGFAAASSMAEGTKAHKKIQSTYKEEDEYEVFLKEALQHEEIEFLLEGRCDGIIQEDGELVVDEIKSTAKDLSAFDEDTHPVHWAQARCYAFMLAKERGLERITVQLTYLQIHTEEEKRFRKVETLSFLEGYVKGLIADFYPYARLMLHHREKRDTSIKALPFPFPEYRKGQRRLAKAVYKSILDEKDLFAQAPTGTGKTISTAFPAIKAMGEGLLSRMVYLTAKTITRQAAEEAFSLMQQKGLHMHTVTITAKDKICFQEQTVCQKEHCPFADGFYDRLNEAVLDILSHESIIDRSVIEKYAMKHTVCPFEFSLELAYAADAVICDYNYIFDPRVSLKRLHTEGKKKTALLIDEAHNLVDRARDMFSADLGKQNFLQLKRAYKNTAPQLSAAAKKMNDVFISFNRELKEESYRIHEELPENLLEHLEDFAHCSEKELISGRGDEGQELLLDTYFSVQAFLRISRLADERFVIYTEKSGKDVVLKLFCLDPSYLVQKMGKGFRSKLFFSATFQPFDYFKNMLGWNEDHYSLSLPSPFPKENAEVLALPLSTRYKDRSATGEALIRSVEKLAAERPGNYLIFFPSYQYMREIHEQMKESSTIRMMVQEQGMAEGEKEEFLSSFKEEPEESLLGFAVLGGIFSEGINLKGTRLCGVIIVGVGLPQLSLERNLIKDYFQAEGKNGYDYAYTFPGANKAAQAGGRLIRSEEDTGTILLIDDRFLQKRYEQLLPAEWFPLKRLTR
>NC_022524.1|WP_009791082.1|2041500_2041947_+|C40-family-peptidase
MKKLITSVFLCTSLLFAGLFGGENTEAASYGSSAAAVAQKYIGVPYKWGGTSPKGFDCSGLVGFTYSKAGKKIPRTTGQLYKTGQAVQKKSLKKGDVVFFSTYKKGPSHVGLYLGGNKFIHASSSKGVKIDSMSNPYWSKAYYGAKRI
>NC_022524.1|WP_009791081.1|2041093_2041285_-|hypothetical-protein
MQQLPLLYLACILAGYALIQTAGLAFVTGGFAAFITAVGVTAMIIFAAALLFLGLKALLGRKL
>NC_022524.1|WP_009791080.1|2040011_2041046_+|mechanosensitive-ion-channel
MDFFKELSREEYIQFFSWFAAIWLLKFILQFFAARRRWAQPEAKEGMLSVLNWAAFYASLILFLNFFSTQDWLNYTLYQAGDVKVSLRLIFTAFLIVSLANKFVRVLTLQILSSVYEHYHVDRGLRYTFNRFIYYAIMIAAVAVSLTTVGLDLTAAGAALGVLGIGIGFGMRNIAGNFISGIIILFERPVEVGELIEINNKIGTIESIRLRSTIVRTAKEGTLIVPNQHFIEQIIKNRTGSEMLASVEVNIKFGEDTGRIENLLKEAVLQEANHFSAYLKVNLAEIRLVDFKYDTMLFLIEVPVKNFDTKQKYESRLRHAIAGIFYEHDISLASFPAAEKEAGM
>NC_022524.1|WP_009791079.1|2038760_2039846_-|AI-2E-family-transporter
MWIKKPFFMYITGAILVLVVIFLLGKIDWFIWPFRKLVATIFFPILISGLLYYILRPVIRWLSGYMPKTASILIVFGTLIGIGTGIFYFGGSLIAEQITQISDSFPDKMEDLTSETKEMVDENDFGFLSYEEIEQKVLSYSQSFINTVGSNLTGIISAITSIATVLIVVPFILFYFSKDDEKLRPKLLKWIPDEHKIEGNRILLDIDKTLSTYIIGQFIIAFADGVLMYIGYLIIGLDYALVLALFATFLTVVPFLGPLLGIIPAIFVGLMQEPFMVIKILIVLVAVQQLEGNLITPQVMGKRLNIHPLTVILVLLVAGSLYGFIGILVAIPFYSVVKVIVRDFWKFYRLRHLAGSIGNKE
>NC_022524.1|WP_022543786.1|2037272_2038697_+|PAS-domain-S-box-protein
MKNSNMFMQLFYQSRIPQTVVIGHIDQVIVNEAFCKFLGYSMEEWAGLTIEDISHPDDYKKDLELLNEILDGKRTEYELEKRYICKDGSHKTGQLNLSLVKGESADDQYMFGQIVDITEQKRLESKREESEQNYRLLADNISDLIILHKYDATYLYASPSVNRILGYEPDEMLELNAFKLIHPDDIEEVRRRYQLMLRIGEPLLITHRVKKKDGSYIWMESHVKGIDEYTFESGAQILSVSRDIQQRIETNELLRRSEKLAVVGQMAAAVAHEIRNPLTPIKGFMQLFSDGRDFNPAFSSIIINEINRIDNIITEFLALAKPHSTKVEVLDLNDVIRHVVDLMMPQALMNNKELTFEPGNGPYPLLGDPNSLKQLFINIIQNALDAIEEKGSSIISTVKADGELCAIIKDSGCGIPAERLANLGEPFYSTKEKGTGLGLMTSYKIADDHHGRVKVESDEGKGTTVRVYFPVHGM
>NC_022524.1|WP_009791077.1|2036066_2037116_-|M42-family-metallopeptidase
MTNSNVKQTADLIRELVSIPSPSGNTSEVISFVQNYLEQLGVHTYQNRKGGLIATLPGKNEKQHRMLTAHVDTLGAIVKEIKPNGRLKIDLIGGFTYNSIEGEYCEIETAEGNKYTGTILMKQTSVHVYKDAAKAERNQQNMEVRIDEKVHSKEDVLALGIEVGDFVSFDPRVQETESGYIKSRHLDDKASVAILLQLIKTLKEKNIELPYTTHFLISNNEEIGYGGNSNITPETVEYLAVDMGAMGEGQSTDEYTVSICVKDASGPYHYGLRKNLIKIAKDNHIDYKLDIYPYYGSDASAAIRSGHDIIHGLIGPGIDSSHAYERTHMESLDNTARLLFHYVQSELVN
>NC_022524.1|WP_050767245.1|2035500_2036031_+|M15-family-metallopeptidase
MIYLLFLMKAEQFPEIDFHIDMDNGFDEDAPLPVQLHPVVSAKKDELISLAADKGINIVITQDFRSIEEQNELYAKGRTAEGEIVTNAKGGESYHNFGLAIDFALLSLNGAVIWDMNYDGNGNSRADWDEVVEIAKGLGFEWGGDWRSFKDYPHLQYDFGLSIWELQRGKRPPEEE
>NC_022524.1|WP_009791622.1|2047235_2047850_-|hypothetical-protein
MKERILFFAAGLLVLTLGVALIIKSALGASAWDALAVGESHLFGLTVGTCIFINGMALIIINSILLKKKPEILAAGTILVIGALIDFWLLAVFKDFSPSMLLTQSCTLLSGILTMGLGIAVYLQAKFPPSPMDTLMVAVHTRFGLSLRTSRIASEGFALILAFLFQGAIGPGTILVTLTLGLVVQYFHPKLEIIMANGLKKAVV
>NC_022524.1|WP_009791623.1|2048219_2050190_+|LTA-synthase-family-protein
MKSILKSPKELFKNSMSVFFLAVVLLWLKTYAAYQIEFNLGIDNSMQEFLLFLNPLSSSLLFLGIALFFKGKIQSGVLIAVQFLLSFLLYANVVYYRFFNDFITVPVLMQTKTNAGQLGDSALSLMSPFDILYFADTILLVVLAAVKWYRPAKHTRKRMTASLVIAAAVITFFINLGLAEKDRPELLTRSFDRNYLVKYLGAYNFTVYDIIQNARSASQRAMADSSDITEVENYVKANYAEPNPDYFGKAKGMNVIYVSLESFQTFLIDYKLDGQEVTPFLNSLAHNGQTFYFKNYFHQTGQGKTSDAEFMMENSLYPMSQGAVFVNKAQNTYQAAPAILKTRGYTSASFHGNYKTFWNRNEIYKSFGYDHFFDAEYYNMTDENTKNYGLKDKPFFKESMPMLESLKQPFYTKFITLSNHFPFKMDEGDTEFQPAETEDSVVNHYFTSANYMDQALEQFFNDLKASGLYDNTVIVMYGDHYGISENHNPAMERVLGKEIDSFEYAQLQRVPLFIHVPGVKGGAMDTYGGAVDVMPTLMHLLGVSTKDYMQIGSDLLSETHREVIPFRNGDFISPEYTSVDEKCYSTETGEELEEGSACVRLSEQAKKELLMSDNIVYKDLLRFHNPEGFEPINRKDYKYIKEEPAEEANPMTGLQK
>NC_022524.1|WP_009791624.1|2050323_2050557_+|hypothetical-protein
MSECQLNHSAEDVKNKYEQQKEHLPSQLQPLMEEFLQKEHTQEILNDVFHLLKKYDLASEDEKEERERRLYLVVNNV
>NC_022524.1|WP_009791625.1|2050639_2050879_+|hypothetical-protein
MFEEVSFMQLQNRHIIKKALVFAVEGTQTPAGNSGRVETPQRAAQGGLGFVPRKAKCLERKTPAPFKSKTNFKTILIIF
>NC_022524.1|WP_022543788.1|2051001_2051964_+|RNA-polymerase-sigma-factor
MEGNQGLHTISKEIKDLEKRFKQEIEPYRSLLWKYCYRLTGSPWDAEDLVQDTLLKSLAMLSKVFQELNVKSYLFKIATNTWIDQQRRNRIAYTDSYLVELLESGSEKELKILPALDYLARQLSLKQFVCLLLTDVFLFTAKEAADIVSLSPGAVYANVQRARDVLKNIPEREQIHRLQEGIAISASHDKTISTLLEGFRRKDMAMIASLLDENLLTDITHAGVEFGKRETERNSLKDWAEVVSRQEGAEAAITTLWGRQVILEFALKSGEKLLQNIHFMELENDKIVYWKFYCFSWDLMNAAAKELDVNLGAEYFYHIF
>NC_022524.1|WP_022543789.1|2052055_2052427_+|VOC-family-protein
MKTPIVNRMNTIFVHVADLEKSAGWYCKLLGQKVTEPVENPVYNVKMNGATGLTLDAGPYGERERPQAGLYPLFNLHTEDIQEAYSWMESEDFAVDPEITRFDDFSFFNVKDPDGHIIMICTG
>NC_022524.1|WP_009791628.1|2052448_2053171_+|nucleotidyltransferase-domain-containing-protein
MTEIKERLPAVETAQMLINERFPDCRGAILGGSIVRGEGTATSDLDIIVINDKAGSVRRESFHYKGWPVELFEHTKDSCRGYFQKDAERARPTLPRMVAEGLVLRGKDFLGGIRKEAAALMAAGPALWTDAELTFKRYFLTDALEDFIGSTKRHESLFIAGKLAELAHEFLLRTNKQWIGQSKWIYRELSHYDQALAYRFAECFDGFYQFGEKQPVIELVDDIMKPFGGRCFDGFSLSGK
>NC_022524.1|WP_022543790.1|2053205_2054390_+|serine-tRNA(Ala)-deacylase-AlaX
MEKLYYQDPYIKEFTASVIRQDQNSDGKWYAVLDRTAFYPTGGGQPFDTGTIHGISVTDVEEEEGEIRHYLEERLPESGEVDGRVNWQRRFDHMQQHSGQHILSAAFDELFGYRTVSFHLGKETLTIDIETENLSEEEAARAERKSNEIITDNLPIETKWVSESELAGYPLRKETKVKENIRLVIIPEFDYNGCGGTHPKATGEVQAIKILGWSRQKKQTRVEFVCGGRVLKQLHTKNVIVNRTGQLISSPEGEIPEAIIKLLDTQKQMEKELEELKNQLLEQEGKEYARSILDGSAIIRKVFRDRNVKELQKLAKSIAIQNDQAIVLFAAENGRQLQAVCASGTKTEADMKKIIQSILPAIHGRGGGNKHFAQGGGETEMSGERLLELMADSL
>NC_022524.1|WP_009791630.1|2054924_2055140_+|helix-turn-helix-transcriptional-regulator
MKNNLAELRKKHGFSQDRLAVRLGVSRQTIISIEKGKYSPSLPLAFQIAKTFDTTIEHIFIYEEETNKKGE
>NC_022524.1|WP_009791631.1|2055144_2055519_+|hypothetical-protein
MESRLTFFICGGLFLIMTLFMAVIGISAGESILPQTWTLLSMTVMSFSMGYLYPQFKQKDERMKMIRQKGLFYAYFALIVYFFIFFLLLGLGIIDISALELLQILSGLTISTVFLSMVYVSKRI

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Crispr_ID: NC_022524_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_3

2567503-2567613

Orphan

Consensus_repeat	Method
GACCACTCTGGAGAAGGCCACTCCCAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022524_3

>merge|NC_022524|3|2567503-2567613|CRISPRCasFinder
GACCACTCTGAAGAAGGCCACTCCCATGAAGGAGAAGACCATGACCACTCTGGAGAAGGCCACTCCCATAAAGGAGAAGACCATGACCACTCTGGAGAAGGCCACTCCCAT

>NC_022524|3|3|2567503-2567613|CRISPRCasFinder
GACCACTCTGAAGAAGGCCACTCCCAT	GAAGGAGAAGACCATGACCACTCTGGAGAAGGCCACTCCCATAAAGGAGAAGACCAT
GACCACTCTGGAGAAGGCCACTCCCAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_009793464.1\|2570098_2570854_+\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|212491
NC_022524.1\|WP_009793469.1\|2565201_2565960_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
NC_022524.1\|WP_022543943.1\|2557247_2558588_-\|branched-chain-amino-acid-transport-system-II-carrier-protein	unknown	unknown	gnl\|CDD\|283235
NC_022524.1\|WP_009793463.1\|2570972_2571545_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009793470.1\|2564104_2565124_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NC_022524.1\|WP_009793474.1\|2559545_2560115_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009793459.1\|2573047_2574052_-\|DUF3231-family-protein	unknown	unknown	gnl\|CDD\|371599
NC_022524.1\|WP_009793456.1\|2575673_2575973_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009793461.1\|2571918_2572335_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NC_022524.1\|WP_009793465.1\|2569206_2569797_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_022543947.1\|2574907_2575549_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380440
NC_022524.1\|WP_009793473.1\|2560358_2561816_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143404
NC_022524.1\|WP_009793458.1\|2574200_2574713_-\|ATPase	unknown	unknown	gnl\|CDD\|176868
NC_022524.1\|WP_009793475.1\|2558848_2559505_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_022524.1\|WP_009793460.1\|2572394_2572790_-\|transcriptional-regulator-Spx	unknown	unknown	gnl\|CDD\|179316
NC_022524.1\|WP_022543944.1\|2563363_2563987_+\|NAD(P)H:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|179647
NC_022524.1\|WP_009793466.1\|2568371_2569163_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|132912
NC_022524.1\|WP_009793477.1\|2555494_2556340_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381358
NC_022524.1\|WP_009793472.1\|2561853_2563050_-\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341473
NC_022524.1\|WP_009793468.1\|2565984_2566803_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|366361

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_009793464.1\|2570098_2570854_+\|glucose-1-dehydrogenase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	8.91615e-81
NC_022524.1\|WP_009793469.1\|2565201_2565960_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	4.63967e-24
NC_022524.1\|WP_022543943.1\|2557247_2558588_-\|branched-chain-amino-acid-transport-system-II-carrier-protein	gnl\|CDD\|283235	pfam05525, Branch_AA_trans, Branched-chain amino acid transport protein. This family consists of several bacterial branched-chain amino acid transport proteins which are responsible for the transport of leucine, isoleucine and valine via proton motive force.	4.47446e-160
NC_022524.1\|WP_009793470.1\|2564104_2565124_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	2.94797e-34
NC_022524.1\|WP_009793459.1\|2573047_2574052_-\|DUF3231-family-protein	gnl\|CDD\|371599	pfam11553, DUF3231, Protein of unknown function (DUF3231). This bacterial family of proteins has no known function.	6.98898e-64
NC_022524.1\|WP_009793461.1\|2571918_2572335_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	3.33861e-25
NC_022524.1\|WP_022543947.1\|2574907_2575549_+\|cupin-domain-containing-protein	gnl\|CDD\|380440	cd20306, cupin_OxDC-like, Oxalate decarboxylase (OxDC)-like cupin domain. This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.	1.94547e-57
NC_022524.1\|WP_009793473.1\|2560358_2561816_-\|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl\|CDD\|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0
NC_022524.1\|WP_009793458.1\|2574200_2574713_-\|ATPase	gnl\|CDD\|176868	cd07826, SRPBCC_CalC_Aha1-like_9, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	2.57096e-31
NC_022524.1\|WP_009793475.1\|2558848_2559505_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	8.28702e-37
NC_022524.1\|WP_009793460.1\|2572394_2572790_-\|transcriptional-regulator-Spx	gnl\|CDD\|179316	PRK01655, spxA, transcriptional regulator Spx; Reviewed.	3.59531e-72
NC_022524.1\|WP_022543944.1\|2563363_2563987_+\|NAD(P)H:quinone-oxidoreductase	gnl\|CDD\|179647	PRK03767, PRK03767, NAD(P)H:quinone oxidoreductase; Provisional.	7.61551e-60
NC_022524.1\|WP_009793466.1\|2568371_2569163_+\|hypothetical-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	2.8626e-30
NC_022524.1\|WP_009793477.1\|2555494_2556340_-\|aldo/keto-reductase	gnl\|CDD\|381358	cd19132, AKR_AKR5D1_E1, AKR5D and AKR5E families of aldo-keto reductase (AKR). 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).	1.68405e-164
NC_022524.1\|WP_009793472.1\|2561853_2563050_-\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341473	cd08194, Fe-ADH-like, Iron-containing alcohol dehydrogenases-like. This family contains iron-containing alcohol dehydrogenase (Fe-ADH) most of which have not been characterized. Their specific function is unknown. The protein structure represents a dehydroquinate synthase-like fold and belongs to the alcohol dehydrogenase-like superfamily. It is distinct from other alcohol dehydrogenases which contain different protein domains. Alcohol dehydrogenase catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions.	0
NC_022524.1\|WP_009793468.1\|2565984_2566803_-\|VOC-family-protein	gnl\|CDD\|366361	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	2.15148e-09

>NC_022524.1|WP_009793468.1|2565984_2566803_-|VOC-family-protein
MTFRWDGGFIMVSWDGFEEGVEWYTKHFGWSCLDKIISPVGKKAFLKMPRLGVVTLKSFEGNFEHFQKDSGTEGHVRLCFEILDIDRSLSYFKNEGIEVTPIAELPGGQKSFDIFAYENARITAVYNSDEADQFPDARITGFGPVNARIGVRNLDEAISWYEEHLGLRLAKRFGSEFAHMQVEDAYDWIQHKQIFHDSVWLETAAGTAFEKGSPSARNYFDLRPDEFYHTYELLSEKGLSPSEIAGNPTAGWGGFHFYDPDGNMINVWSYPL
>NC_022524.1|WP_009793469.1|2565201_2565960_-|MerR-family-transcriptional-regulator
MNIQKFAERTGLPPSTLRFYDRKKLILPAGRSEKGYRIYTEEQIHKAMIIHSLRQADIKIEEIQSYLEAEEEEKKTWISGWKREIEEKLASMNIAKQYLSSMHAEERHLHLVKWEGDNCFIWFRCTVPRAFHPFQEKMSEISERLRILRIETKPGVFVRTLESKGDTIAGEVGFLLHNIPGKEIDFFDDLYTEPFGPRIFAAVECNVYDPFTCFHYMRQIHRFGFKAEGMKLEKYEFPESRTFSYLIPLAGS
>NC_022524.1|WP_009793470.1|2564104_2565124_-|RNA-polymerase-sigma-factor
MFSQVFSVLQVRYKKGGVFVEKHNDLSSISKDMKELAPSFDCIVQPYREQLWHYCRKLTGSPWDAEDLLQDTLLKAFSSLSRIGQTMNAKSYLFRIATNIWIDHCRKKSPQLLDMESEKIPDGDLVPYSEVLESVEILIHQLPAKQAAAILLAEVYRFTIRETAEMIGSTEGGVQSLLSRARANLKKQKAVENLPFQEAVLADEKKQVIQQYMDYFVKGDFKSIGELLGKYATNEVVGQGMDIGKTQIRKNSMGDWGSSTAGLSAELAFLWGRYAVIYTRDAGCGPVLWDIATAEIEDGKLIRHKSYYFCREFLEAAAAELSIKLDTEKDLFGQEWQGI
>NC_022524.1|WP_022543944.1|2563363_2563987_+|NAD(P)H:quinone-oxidoreductase
MTVKLAIVYYSSTGTNYQMAQWAAEGAKEAGAEATIYKVQELAPESVIEGVPAWKAHLEETKDVPVVTPDDIAEADAIIFSTPTRFGNMAAQMKQFLDTTGGIWGAGKTVNKVVSGMTSAQNPHGGQEATILSLYTTMYHWGAIVVTPGYSDQSLFPAGGNPYGASVTVDQSNEIVGDKDAYKGAIKYQAKRVIGIAESVKNGAGQQ
>NC_022524.1|WP_009793472.1|2561853_2563050_-|iron-containing-alcohol-dehydrogenase
MKKPAVFRVPESIFYGRGSFENLGSQAALKGKKALIISDNVMDQLGYVTEGRALLHVAGVQSEVYLGIASEPTDKYVSEALDLFKSEQCDLVISIGGGSCIDTAKAIAVLAVNGGSIGDYLGGKKLAQQTPVPHIAIPTTAGTGSEATDVTVITNTFNNVKMMIKQPAFLPDAAIVDPLLTVSSPKNITAATGIDALSHAIEAYLSKKAHPMTDTMAISAMKLIAENILTAYNDGGNLDARERMSLGSLQAGMAFSNASVCLVHGMSRPIGALFHVPHGISNAMLLPAVLEFSQEACVERLADIGRIFRPDIVSGDGVKAAEIAVQSVKELCRKLNIPNLKEWGIDGEAFEKAVGKMAADAIDSGSPANNPKVPSQLELEELYHICYDYHFSSASEKV
>NC_022524.1|WP_009793473.1|2560358_2561816_-|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MATKTANILKNFINGDWVDAKTERFEAVPNPATGEELARTPISTKEDVEDAVQAAREAYKTWSKTPVPKRARILFKYQQLLIDNWDELAKLITQENGKNYKEAYGEVQRGIECVEFAAGAPSLMMGKQLPDIATNIESGMYRYPVGVIGGITPFNFPMMVPCWMFPLAIACGNTFVLKPSERTPILANRLAELFAEAGLPEGVFNIVHGAHEVVNSLIDHQDVPAISFVGSQPVAEYIYKSASAKGKRVQALAGAKNHSIVMPDADLDGAVKEIIAAAYGSAGERCMACSVVVAVDSIADELAAKLQEQADSLTIGNGLDEDIFLGPVIRQENKVRTRHYIEVGEKEGAVLIRDGRKDEAYHENGYFIGPTIFDHVDPTMKIWKEEIFAPVLSIVRVKSLEEAIEVTNLSDFGNGACLFTDSGSNVRYFRENIEVGMLGVNIGVPAPMAFFPFSGWKNSFYGDLHANGSDGVEFYTRRKMLTARW
>NC_022524.1|WP_009793474.1|2559545_2560115_-|hypothetical-protein
MSYSEYWDKIFQLSEEMTSLVDSYWKSYSGPGSWQFWAVAVLLVLPLVLLYFTVDRKRIFEIFFFGFIVHALWTYTDIVLGNYTLLVHTYYMLPIFPHAFNITMSVLPVGFMLIYQYCTSHGKNFILYTIILSAVYSLVFASIEKALGMVELNKGMNLFYLFLIDLAIAFIAYIGTRLVRRAHLRADAE
>NC_022524.1|WP_009793475.1|2558848_2559505_+|GntR-family-transcriptional-regulator
MPIPANFASPARVSAKDRAFLQIQEWIIDGTLKPQEKLNDGDLAKALGVSRTPIREALQLLSVQGFVEMFPGVGTQVTTVNPEDINKILPPLGALQALAAELAAPYMDSSTIEKLRSINRSFADSLLRGDTFSALKQDEQLHNLIIEKADNPYITSYVSSMQAHVMRLYYNKTIILKPRSIDEHEDIIKAFEEKNTHKASDVARTNWLRAIDEYYGEK
>NC_022524.1|WP_022543943.1|2557247_2558588_-|branched-chain-amino-acid-transport-system-II-carrier-protein
MGTKIPFSYVVAVGFMLFALFFGAGNLIFPAMLGQSAGTSIWSANAGFIVTGVGLPLLGILALGFSGKSNLQSLAGRVHPAFSAVFTMLLYLSIGPLFAIPRTATVSFEMGVKPFLAGNSTIGLIVFSVLFFAVTGFFSLKSSKIVDIVGKYLTPILLIVVGILIIAAFFNPMGSFQSPGENYLANTFFKGFQEGYLTMDALAAFVFGIIVVDAVKERGAATRKEIMVSIAKAGLIAAALLAIIYTSLSYIGASSVGELGRLDNGGAVLSGASEYYFGSFGALLLSVIVLGACLTTSIGLVTACSSYFHKVFPSVSYTVFVVILSVFSAVFSNIGLSQLISISVPVLTGIYPLAICLMFLTFLHPLFKGKKEVYQVSMLFTFIVSLFDGLKAAGLSFGPVEEVFSTILPLYEVGLGWIMPAVVGAVIGFFVAAIRSGGVSQAKESI
>NC_022524.1|WP_009793477.1|2555494_2556340_-|aldo/keto-reductase
MVNGIPEVKLNDGLSIPAIGLGTYQLKGSAGAESIRKAIDEGGYRLLDSAYNYENEGTVGEAVKRSSVSREDLLITSKLPGRYHESAKGMIAIEESLYRAGLDYYDIYLIHWPNPKRELYVEAWQTLIEAKKKGYVRSIGVCNFLPEYLDRLEKETGVKPSMNQVELHPYFNQEEQRAYHEKHGILTESWSPLGRGSDLLGNGDIQKIAEKHGKSIAQVVLRWHYQLGAVSIPKSSSAERQKENISIFDFELDVEDMEAISKLSHPGGRLHDQDPAEYEEF
>NC_022524.1|WP_009793466.1|2568371_2569163_+|hypothetical-protein
MSSIGRLPEHMQPLDALKSIGENIIIADKDYKVAWMNDNARKLLSQAAPLFGFAGSEDLIGLSMDRFHRNPGHQKQIMKRLKGSHRSRINIKDQFVTDIVISPVNDKNGQINGYIVMLMDVTTKSEEDRKKEVLIQALSVPMITIWDCTLALPLIGGYDKERSDYVLGRLLEKCVKDKIKYVLIDLSGLYDFQEETKFELQKLYDCLRLIGTECLLVGMTAELARTAGDIHPSIQSFRSAHEGLKYLIKRNFPSETELSSNFL
>NC_022524.1|WP_009793465.1|2569206_2569797_-|hypothetical-protein
MENKRVEEFDKIVEMNEKGQDALNSYWMDYSLYASFEYWLMAAFFFVPLIVLYFRIDRSRIFLLGFYGYSIHVFFNYTDWYGKNSGFWNYPFPLVPVTPGISLDSSLIPVVFMLVYQWTLNKGKNYYVYSILTAVFLAFVFKPFLIAVGLFRLYGDTHYFHLFGGYLIVLLTAKVITNIFLWMEKRYKQSARKEKK
>NC_022524.1|WP_009793464.1|2570098_2570854_+|glucose-1-dehydrogenase
MSSNKAAIITGAGSGIGQSTAVRLAKEGVDIAVVDISEKGGNETVEMVKGLGANAIFIKADVSRKEEVKNYVDKTLEEFGKIDYFFNNAGISGSGQFFLNTSAEEIEQIVGINLMGALYGVRYVAEEMLKKGGGSIVNTASSAGVIGQDSVVTYSATKHGIVGLTKSMVAEYAKDGLRVNAIAPGPTETPMVKAFYEANPEMKENATGGIPQKRLGTPEEVAELVTFLLTSKAEYINGEVIRIDGGFTNTK
>NC_022524.1|WP_009793463.1|2570972_2571545_-|hypothetical-protein
MGERQREMLKDIREKAGALSSEQIEYWKEYSSFNDWQLWAVIIILIVPLILLYFKIDRSKILLLGFYGLNYHIWFAYTNSIGIRLGLWEYPYELLPVLPSFALDASFVPVTFILLYQWTLNHKKNFYLYSLLLSAVFAFVIKPILVSLDFFRMFKGVNYFHLFLCYIAFFLVAKIITNIFISMQKNRAEV
>NC_022524.1|WP_009793461.1|2571918_2572335_-|Rrf2-family-transcriptional-regulator
MNSDFTLAIHSLAYLALQLDRMSTSEAISKSAGVHPVRIRKVLSLLKRNGFIKSKEGTGGGFIFARELDEVSLWDIYKITSEGALQPKCPESNEQCIVGANMRNVLFSIFIGAEEHLGEYLKDYTIKDIVELVNQDSN
>NC_022524.1|WP_009793460.1|2572394_2572790_-|transcriptional-regulator-Spx
MVNLYVSSSCTSCRKAKAWLEEHNIEYTERNIINEPLSVEEIKSILRMTENGTEEIISTKSKAYQQLDMEIDSLPLKELYQLIADNPQMLRRPIIIDEKRLQVGYNDEEIRSFLPRKLRTFSFMQMQNLAN
>NC_022524.1|WP_009793459.1|2573047_2574052_-|DUF3231-family-protein
MEQIQHQTKMNASEYAVIWSQYINDSLSSCVLQHMLKDAEDKNIREVFEFALELSEPHLEKTKKLLKSENQPLPIGFSEEDVNADAPGLFTDAFKIVYLHIMALHGLTRYAGATSVCSRKDIRQYFMQCTSEALELYDRTTEVALQKGIIDKAPTLHNKQKVHFIKNGYMKGWLGKRRPINAIEISGVFLNMQKTMVKMVLELGFSQVCKSNDVRAYMERARGLCVKHFEILASLLKEENLHVPKVFESEVTDSTVPPFSDKLMLFHITGLLSAAISYYGKAAALSQRRDIVSAYTRMNVEIALIAEDGMQLMIKNAWFEAPPAAADHEALAKE
>NC_022524.1|WP_009793458.1|2574200_2574713_-|ATPase
MSGKLIMREEGNNLIMEWIFDAPREEVFKAFSDSKLLESWWGPEGWETNNKKFEFEPGGIWHYGMTCKDKSQGEFYGMESWGLAVYKEISAPEKIVHTDAFSDEEGNINESLPKTLITATFSEEEGKTKYVSVTEFPSSGAIRQIIDMGAAEGFSSQLRKLDALLSGNKV
>NC_022524.1|WP_022543947.1|2574907_2575549_+|cupin-domain-containing-protein
MTAYLDYTSPSLAYAFDVNKSPLMKKDKHNFINILGIAQLNTLENVSLLDIFLSTGNAVEPHYHQNAAELVYCISGKATVSLLNPFTKNIQNYTIGPGQVANVPQGWWHYEVALQDNTHLLAIFNAPTPEVILGSDILKFTPANIMANTYCIDENQWNETVAQVQPTAYIGPANSCSKSKKMARRHHYSYGHQGSTSRRSAYSRAGYWPVYPG
>NC_022524.1|WP_009793456.1|2575673_2575973_-|hypothetical-protein
MEYGKENRMFITIPLALALFLEFAIEPVFKIREKLFNRLGTMAAGALAITLPFAAWLLLTELVPIEDERVYTFSCIMFTVFIGSGAGKKYSNSKEEKQL

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Crispr_ID: NC_022524_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_4

2720829-2721175

Orphan

Consensus_repeat	Method
AGTGACTCATATCTTCCTCTTGAGNCACTCTG	CRT

6 spacers

The CRISPR arrays of NC_022524_4

>merge|NC_022524|4|2720829-2721175|CRT
AGTGACTCATGTCTGCTTCTTGAGTCACTCTGTTCAGCTTTCACCCCCATCAGAGTGACTCATCTTCCTCTTGAGGCACTCTGTGCTGCTTTCACCACCTTCAGACTGACTCATATCCTCTTCTTGAGTCACTCTGTTCGGCTTTCTCCACCACCATGGTGACTCATATCTTCCTCTTGAGTCACTCTGTGCGGCTTTCACCACCTCCAGAGTGACTCATATCCTCCACTTGAGGCACTCTGCTCTGTTCTCTCTCCATCAGAGTGACTCATATCTTCCTCTTGAAGCGCCCTGCCAGGCTTTCCCCACCATCAAAGTGACTCATATTTCCCTCCAGAGGCACTCTG

>NC_022524|4|1|2720829-2721175|CRT
AGTGACTCATGTCTGCTTCTTGAGTCACTCTG	TTCAGCTTTCACCCCCATC
AGAGTGACTCATCTTCCTCTTGAGGCACTCTG	TGCTGCTTTCACCACCTTCAG
ACTGACTCATATCCTCTTCTTGAGTCACTCTG	TTCGGCTTTCTCCACCACCAT
GGTGACTCATATCTTCCTCTTGAGTCACTCTG	TGCGGCTTTCACCACCTCCAG
AGTGACTCATATCCTCCACTTGAGGCACTCTG	CTCTGTTCTCTCTCCATCAG
AGTGACTCATATCTTCCTCTTGAAGCGCCCTG	CCAGGCTTTCCCCACCATCAA
AGTGACTCATATTTCCCTCCAGAGGCACTCTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_022544005.1\|2715209_2715404_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_156917059.1\|2716663_2718076_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NC_022524.1\|WP_009793255.1\|2724720_2726229_-\|tripartite-tricarboxylate-transporter-TctA	unknown	unknown	gnl\|CDD\|225870
NC_022524.1\|WP_022544006.1\|2715520_2715796_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_022544011.1\|2730280_2730712_-\|DUF4362-domain-containing-protein	unknown	unknown	gnl\|CDD\|372994
NC_022524.1\|WP_009793261.1\|2721217_2721700_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213039
NC_022524.1\|WP_009793263.1\|2718847_2719759_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224094
NC_022524.1\|WP_022544010.1\|2726714_2727719_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NC_022524.1\|WP_009793271.1\|2714499_2714898_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_022544007.1\|2715798_2716041_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_035402254.1\|2718154_2718739_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_022524.1\|WP_009793250.1\|2727920_2728598_-\|response-regulator	unknown	unknown	gnl\|CDD\|226931
NC_022524.1\|WP_101548457.1\|2716205_2716454_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372940
NC_022524.1\|WP_009793270.1\|2714980_2715208_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009793260.1\|2721764_2723540_-\|gamma-glutamyltransferase	unknown	unknown	gnl\|CDD\|223482
NC_022524.1\|WP_009793259.1\|2723861_2724203_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_022544008.1\|2719755_2720622_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223674
NC_022524.1\|WP_022544009.1\|2724248_2724518_-\|30S-ribosomal-protein-S14	unknown	unknown	gnl\|CDD\|181574
NC_022524.1\|WP_009793249.1\|2728612_2730193_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225827
NC_022524.1\|WP_009793254.1\|2726241_2726700_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_156917059.1\|2716663_2718076_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.45639e-77
NC_022524.1\|WP_022544011.1\|2730280_2730712_-\|DUF4362-domain-containing-protein	gnl\|CDD\|372994	pfam14275, DUF4362, Domain of unknown function (DUF4362). This family of proteins is found in bacteria. Proteins in this family are typically between 93 and 146 amino acids in length. There is a conserved IRIV sequence motif.	1.26933e-41
NC_022524.1\|WP_009793263.1\|2718847_2719759_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.05189e-30
NC_022524.1\|WP_022544010.1\|2726714_2727719_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	5.88397e-90
NC_022524.1\|WP_009793261.1\|2721217_2721700_-\|hypothetical-protein	gnl\|CDD\|213039	cd11743, Cthe_2751_like, Uncharacterized protein domain similar to Clostridium thermocellum 2751. Cthe_2751 has been found to form homodimers. Based on structural similarity to other families, a role in processing nucleic acids was suggested, though interactions with DNA could not be demonstrated.	0.00203668
NC_022524.1\|WP_035402254.1\|2718154_2718739_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.36127e-14
NC_022524.1\|WP_009793250.1\|2727920_2728598_-\|response-regulator	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	2.97954e-80
NC_022524.1\|WP_101548457.1\|2716205_2716454_+\|hypothetical-protein	gnl\|CDD\|372940	pfam14166, YueH, YueH-like protein. The YueH-like protein family includes the B. subtilis YueH protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	1.06018e-22
NC_022524.1\|WP_009793260.1\|2721764_2723540_-\|gamma-glutamyltransferase	gnl\|CDD\|223482	COG0405, Ggt, Gamma-glutamyltransferase [Amino acid transport and metabolism].	0
NC_022524.1\|WP_009793255.1\|2724720_2726229_-\|tripartite-tricarboxylate-transporter-TctA	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	0
NC_022524.1\|WP_022544008.1\|2719755_2720622_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.60441e-12
NC_022524.1\|WP_022544009.1\|2724248_2724518_-\|30S-ribosomal-protein-S14	gnl\|CDD\|181574	PRK08881, rpsN, 30S ribosomal protein S14; Reviewed.	2.5926e-44
NC_022524.1\|WP_009793249.1\|2728612_2730193_-\|sensor-histidine-kinase	gnl\|CDD\|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	0
NC_022524.1\|WP_009793254.1\|2726241_2726700_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	3.26268e-13

>NC_022524.1|WP_022544008.1|2719755_2720622_-|ABC-transporter-permease-subunit
MATIFRSLTSVVLIIILAVLPLGFHNGDAKVVFSIIPMIDEIRDFIQGLKSGESWLYLQGERERPLLEDLIPYWLSSFLYLTVSAVIAVILSVLFGVFLWEKGGRLLNAVLGFTGMLPDFILVLLLQLLTVFVHKETGIKTVKVASSSMSEPAIFLPIFTLVIIPLFYLLRSLSERSHEVKGEDYILAAKAKGLRKGSIYLFHVFLNVLPFLKADLHKILSIMLGNLFIIEYLYNTRGITALLFVQQIQFGYQYNLVIFSLLSLLLLYLVSLYTLKLLLWLIERGLQR
>NC_022524.1|WP_009793263.1|2718847_2719759_-|ABC-transporter-permease-subunit
MKKRRNLPLAAGLLMLAFFLLAALAGPEIAPYGVNESKKIDHIIDEEGNRKLVSSPFPPSAQHPFGTDKWGYDILTLLLHGAKYTIFTVLGVALLRLVIGAALGIFQGIRTKKGVLNNISLFSGIPIFIFIYFIMLGINIEPKLSPLQLTLIQGALLTILGINGVYNVIFNKTLELKKMAYVEAARTLGGNSSHLSRKHIIPSLRADFSAIFVNECIQVLHIIGQLGIFNLFLGGTEKQYFPTIYLSITNEWSGLIGQSRSFLYHSQWIIIFPLAAYVLLLVAFYLLSAGLKDRKKLNRPTHI
>NC_022524.1|WP_035402254.1|2718154_2718739_-|TetR/AcrR-family-transcriptional-regulator
MNLEGKRKTRESILCAASNLFKCQGYNGTGLNQIIEVSGAPKGSIYYHFPGGKEEIAVEAVKHVGNEIKTMIKKELASSEDAAAAFRYHAEKIASYFDVPLSHENSGLHIGLIASETALTSEPIRQACQETYNEWQSLYKEKLLLSGFSEERSKELALLVSSMIEGAVMLSNTYGNGKPLRNIAEHFTYVFRVQ
>NC_022524.1|WP_156917059.1|2716663_2718076_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MKAVPIIISFLIAGFIGLFSETALNMAIRDLIVIFETDAATVQWLTTGYLLTLGILVPISGLLLQWFTTRQLFAVSLVFSIIGTFIAAIAPVFSILMLARVIQAIGTALLLPLMFNTILVIIPPHKRGGAMGIIGLVIMFAPAIGPTISGLILQNLTWHWIFWISLPFFVLALIFGLFYMQNVSSPTKPKIDLLSILLSTIGFGGIVFGFSSAGEGEGGWGSPKVILALVLGVVGLILFCIRQTKMKQPMINLRTFSYPMFNLGLLMVLIAMMVILSSMIMLPLYLQNSLLLTTFAAGLVLLPGGVVNGILSPVMGRLFDKYGPTWLVRGGLVIVTIVMFAFSGITNDTSAGYIVMLHIFMMVGIAMVFMLAQTNGLNELPPELYPDGTAIMNTLQQVAGAIGTAVAISIMTAGQKSYMEEAANPQDSSLLPLSLTAGIQDAFIFAICVAILGLIASFFIKRVKVEHQEN
>NC_022524.1|WP_101548457.1|2716205_2716454_+|hypothetical-protein
MITSYEKITISGNKYAEVFLNITEDKRFIISIPSISWSAEISQLDELKEQFNHLQSSLNFHMFEGNTEELAAAIIKEAEKHI
>NC_022524.1|WP_022544007.1|2715798_2716041_-|hypothetical-protein
MPVSVIFNQVNVISMSSNSIISTGQNSQPDWNAQGKLNTGNGVYINAASLGNFSFVNDPDVADTPIAQPENINPQPVSQI
>NC_022524.1|WP_022544006.1|2715520_2715796_-|hypothetical-protein
MKSALQNISIKFTNINITSMAANSGIFTGDNTQSGWQVNRKDNTGFGSVTGSQNVSAYNVNIVDDSDFMDAFFYRIEGEEEQGQEHDSQDL
>NC_022524.1|WP_022544005.1|2715209_2715404_-|hypothetical-protein
MANIRFKTIKVNQIQNSSGIFYGQNTPVYWQHTGKISEGFGKVAGKGNKISRNYTRVARSKEGS
>NC_022524.1|WP_009793270.1|2714980_2715208_+|hypothetical-protein
MKKMIGPAKIHFDDIFIGQITDSSGVFMGRNRQKNWSSDINGTSGFGSVAGDLNKISGNLHLVQTEGKKGKESYK
>NC_022524.1|WP_009793271.1|2714499_2714898_-|hypothetical-protein
MQLDDKALITILGKLNGRLADMEGRLKELEKEKSSGHNIHLEINEVNIESFQLDQLSYFLDRIDVKSLSGMMNLGNSFYTPANKQKPQTGKKGNARGTKTAEKNSDDARIRILVNGKETPYALESTTGTEEL
>NC_022524.1|WP_009793261.1|2721217_2721700_-|hypothetical-protein
MSGFIHMEDEEIIYHVYNLNWHLPEETQKEAADILLQLPADKVRMIIPKYGKACWENGVAVIRKIGYPRNENALQRLAGLLQDRNWPGALDSIEVFRDLGKEISSPYIERECEEAIRCRDHDWLEHLYYAVESLGLEFEDFRNGETYEEMRKRAEELREI
>NC_022524.1|WP_009793260.1|2721764_2723540_-|gamma-glutamyltransferase
MKKAASVLFVYLSSFILVFAPLAAADAKHKQDPYEKYGEVAVGEDGMVATAHPLASEIGADVLKKGGNAVDAAVAIQFALNVTEPMMSGIGGGGFMMVYDGKTKETTIINSRERAPAGAEPDMFLDGKGKPIPFAERSSGGTAVGVPGTLKGLEKALDMWGTIPMKKLIQPSIKLADKGFPIDPVLAAAIEDNKEKLSRSAAAEVFLPGGEPLEEGDILVQKDLAKAFKLIRKDGSEALYEGPIGDALAETVQDFGGSMVKDDLEKYEAAIDKPVWGEYQGYQIASMPPPSSGGVFLLQMLKILDGFDLSQYPVRSWEKYHLMSEAMHLAYADRAAYAGDPEFVEVPVKGLLDKDYIKERQQLISLDEMNTKPEAGDPWKYESGKPDYSAAAQPADRQYGETTHFTVADRWGNVVSYTTTIEQVFGTGIMVPGFGVMLNNELTDFDAVPGGANEVQPNKRPLSSMTPTIVFDNDKPVLTVGSPGGPTIITSVLQTIIHAIEYDMELKAAVEEPRIYTNNPSSYRFEEGVPVSALQRLKEMGHRFGEKPETIGNVQSILIDHKQGIFKGVADSSRSGAAIGVDLKGKGKKKH
>NC_022524.1|WP_009793259.1|2723861_2724203_-|hypothetical-protein
MNERLVDIIIREIVSGLPPEDRDLYQYVTNIEDRLAQQSETSDQFMSLLVKHSPHKQAAEKFSLGVTETYQRMQMIEREINKLVEERRTRMKWIDLTDRLDADGQRQLFLFIS
>NC_022524.1|WP_022544009.1|2724248_2724518_-|30S-ribosomal-protein-S14
MAKKSKVAKEKKRQEMVAKYAEIRRELKEKGDYEALRRLPRDSSPTRLKNRCEVTGRPRGYLRKFKMSRIAFREYSHKGQIPGVKKASW
>NC_022524.1|WP_009793255.1|2724720_2726229_-|tripartite-tricarboxylate-transporter-TctA
MGSFEGLLSGFQVALSLQGILFVFLGVFIGTFIGMMPGLGPISAIAIMIPVTYNMDPAIALMMMAGVYYGAIFGGSSSSILLNAPGVSGTVATAFDGYPMAQQGKAGKALAIAAIASFFGGTVSVVLLMLFSPLLSSVAVSFGPVEYFALMLLGLTAISSLSEGSTLKAFISATLGVIVVTIGIDGQTGTARFTFDNAYLLEGIDFLIIALGLFALAEVCTLIFNRKNTSSSENENIGSLKITREDFQEMKGPMARQSVLGFILGVLPGAGATIASFIGYITEKKLAKKPEEFGKGSIRGLAAPETANNAATGGAFVPLLSLGIPGSGTTAVLLGAFLVLGIQPGPLLVQDHPDVFWGIIASMYIGNVFLLILNLPLVPYIAKVLTIPRPMLISLVITFSMVGVYALSFNTFDLYLLLIFGIIGFLMRIFSFPAAPFILAFILGGMMEQALRQTLTISDGSLAILLDRPIGLTLMIIAVLVMIVPLFRRKKKSGSSKGSHAA
>NC_022524.1|WP_009793254.1|2726241_2726700_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MLKPINRKIGLVLIGFALFYLILSFRLPEYPYAAIDADFVPKSLGFLLLLLSVLLFFSRKAETEEEKKKRKIPEGEARTLLTVCAFILVYIFFFEMVGFVVMTALFIFITTWYLGYKKKWTNAIVSVVFSLSIYMMFNYLLQISLPAGILPF
>NC_022524.1|WP_022544010.1|2726714_2727719_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MKKMILAAALLLCMVMMSACSSKEAAGIYKDGKWMPSKPIEVVATAGAGGGWDTTARMVAQTLEKDGLIDQRMPVINKPGGGGAVGWAYMMKKEGNPHNIFVSSPPIILVPLNGQSKYGVDDFTPLSNLIADYAAFAVRADAKWDDLNDLFDDMKKDPSKISVVGVSSPGSMDHIQFIKIAKAAGVDVTKIKYVSDQDGGALTQLLNGSVDVYSAGTSETIEQVRAGKIKVLGVTSPERLKGDTLEDFPTAIEQGINETFVNWRGFFGPPNMDEKQIQYYEERLKKLNDSPEWKKIREKYGWNELYMDSGEYKEFLKKENDELYKLLDELKLIR
>NC_022524.1|WP_009793250.1|2727920_2728598_-|response-regulator
MIKAIIAEDDYRVAAIHEQFIEKLYGIECIGKALNAAEALELLEEKESDLLIMDIYMPDELGSSLLPKIRQCFPNLEVIMITASNEKQMVEESLRYGVIDYMIKPVTFERFTEAIRKVNKKRDLLECRESELTQEAIDHYLSSSSAAVIASEKMPKGIDSLTLKKVKEILDGMKQGVNAEELGKEMGASRTTARRYLEYLVASDEAKAELEYGIVGRPERKYYRL
>NC_022524.1|WP_009793249.1|2728612_2730193_-|sensor-histidine-kinase
MRKKKAVTMRTKIIVLIVWLIAGVIVLLSGLYAYVEFEQTEESMGKQALYVALAVSHMPGVRDAFGEDNPSEKIQPLAERIREDIDAEFIVIGNADSIRYSHPDAGKIGGRMVGEDNERALEQGEAYVSKATGTLGPSIRGKAPIVDDNGDIAGIVSVGFLMDDIEEEALSRLKKIGLISFGAILLGVAGGTLLARDIRKDMMGLEPHEIASLYHERSAILDSVKEGIIAVNRYGVITMMNPSARRILALDEDGVNKRIADVIKGTGMNKVLETGVPEKDVEVLLEEKPVVVNRTPIVENDEVIGAVASFRDKTEINEMLNTLSEVRQYSEDLRAQTHEFTNKLYVLSGMMQLGQYEEAVRMIQEESGAHDQQNLILFEQIRDSSLQAVLLGKLAKASEKKVSFTIDDSSAVEPLPERMTVTHLITIIGNLIDNAIEATEGMADRRISFFATDIGNDIVFEVEDNGGGILPEDEQRIFEKGFSTKEKDGRGYGLALVSQAVGELDGTIEMKTGEAGTIFTVFLPKI
>NC_022524.1|WP_022544011.1|2730280_2730712_-|DUF4362-domain-containing-protein
MKKLFPLYILVSLILLACQTQEEPAPKLPDYKPSEDDIVSMHGEIQNLDRFNSFIVHVQQGRKDTIRVVSYTEEGAPILHDLEYDGQVIHSILDTRRDGFGAGMIEERECKSVDIEKGKKQSNYTLTGCGWKKEDYSILIISK

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Crispr_ID: NC_022524_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_5

3078579-3078653

Orphan

Consensus_repeat	Method
TGTTCTAGAACCGTTATTTTTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022524_5

>merge|NC_022524|5|3078579-3078653|CRISPRCasFinder
TGTTCTAGAACCGTTATTTTTCGTTTATAGCAGAATAGTGGTTCCAGCCTCATGTTCTAGAACCGCTATTTTTCG

>NC_022524|5|4|3078579-3078653|CRISPRCasFinder
TGTTCTAGAACCGTTATTTTTCG	TTTATAGCAGAATAGTGGTTCCAGCCTCA
TGTTCTAGAACCGCTATTTTTCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_022544120.1\|3077059_3077266_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|290882
NC_022524.1\|WP_009791255.1\|3083829_3084477_-\|endonuclease-III	unknown	unknown	gnl\|CDD\|223255
NC_022524.1\|WP_009791248.1\|3077807_3078074_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179195
NC_022524.1\|WP_009791259.1\|3087261_3087432_-\|YpmA-family-protein	unknown	unknown	gnl\|CDD\|379458
NC_022524.1\|WP_009791243.1\|3072919_3075316_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|341067
NC_022524.1\|WP_050767248.1\|3078726_3079671_-\|DUF2515-domain-containing-protein	unknown	unknown	gnl\|CDD\|371209
NC_022524.1\|WP_009791237.1\|3067862_3070166_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|224126
NC_022524.1\|WP_083783064.1\|3076323_3076776_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372950
NC_022524.1\|WP_022544123.1\|3079852_3080464_+\|Holliday-junction-resolvase-RecU	unknown	unknown	gnl\|CDD\|235015
NC_022524.1\|WP_022544125.1\|3083299_3083830_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009791240.1\|3071318_3072236_+\|peptide-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_022524.1\|WP_009791244.1\|3075308_3076172_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223674
NC_022524.1\|WP_022544127.1\|3087675_3088524_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225212
NC_022524.1\|WP_009791241.1\|3072324_3072804_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|107221
NC_022524.1\|WP_009791256.1\|3084622_3085330_-\|DnaD-domain-containing-protein	unknown	unknown	gnl\|CDD\|226445
NC_022524.1\|WP_009791258.1\|3086773_3087247_-\|peptidase	unknown	unknown	gnl\|CDD\|227656
NC_022524.1\|WP_022544121.1\|3077349_3077718_-\|YppE-family-protein	unknown	unknown	gnl\|CDD\|378052
NC_022524.1\|WP_022544124.1\|3080498_3083261_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|273955
NC_022524.1\|WP_035401134.1\|3085557_3086742_-\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|235596
NC_022524.1\|WP_009791239.1\|3070419_3071322_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223674

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_022544120.1\|3077059_3077266_+\|hypothetical-protein	gnl\|CDD\|290882	pfam14178, YppF, YppF-like protein. The YppF-like protein family includes the B. subtilis YppF protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved LLDF sequence motif.	5.15918e-28
NC_022524.1\|WP_009791255.1\|3083829_3084477_-\|endonuclease-III	gnl\|CDD\|223255	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair].	1.44053e-111
NC_022524.1\|WP_009791248.1\|3077807_3078074_-\|hypothetical-protein	gnl\|CDD\|179195	PRK00977, PRK00977, exodeoxyribonuclease VII small subunit; Provisional.	0.00657209
NC_022524.1\|WP_009791259.1\|3087261_3087432_-\|YpmA-family-protein	gnl\|CDD\|379458	pfam14084, DUF4264, Protein of unknown function (DUF4264). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	1.3187e-20
NC_022524.1\|WP_009791243.1\|3072919_3075316_-\|ABC-transporter-permease-subunit	gnl\|CDD\|341067	cd09604, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains bacterial M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.07097e-114
NC_022524.1\|WP_050767248.1\|3078726_3079671_-\|DUF2515-domain-containing-protein	gnl\|CDD\|371209	pfam10720, DUF2515, Protein of unknown function (DUF2515). This family is conserved in Firmicutes. Several members are annotated as YppC. The function is not known.	1.8835e-175
NC_022524.1\|WP_009791237.1\|3067862_3070166_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|224126	COG1205, COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only].	0
NC_022524.1\|WP_083783064.1\|3076323_3076776_-\|hypothetical-protein	gnl\|CDD\|372950	pfam14179, YppG, YppG-like protein. The YppG-like protein family includes the B. subtilis YppG protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 115 and 181 amino acids in length. There are two completely conserved residues (F and G) that may be functionally important.	2.31398e-16
NC_022524.1\|WP_022544123.1\|3079852_3080464_+\|Holliday-junction-resolvase-RecU	gnl\|CDD\|235015	PRK02234, recU, Holliday junction-specific endonuclease; Reviewed.	1.02207e-116
NC_022524.1\|WP_009791240.1\|3071318_3072236_+\|peptide-ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.15382e-24
NC_022524.1\|WP_009791244.1\|3075308_3076172_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.69882e-11
NC_022524.1\|WP_022544127.1\|3087675_3088524_-\|hypothetical-protein	gnl\|CDD\|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	3.54e-15
NC_022524.1\|WP_009791241.1\|3072324_3072804_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|107221	cd06464, ACD_sHsps-like, Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.	4.56264e-23
NC_022524.1\|WP_009791256.1\|3084622_3085330_-\|DnaD-domain-containing-protein	gnl\|CDD\|226445	COG3935, DnaD, Putative primosome component and related proteins [DNA replication, recombination, and repair].	3.35695e-60
NC_022524.1\|WP_009791258.1\|3086773_3087247_-\|peptidase	gnl\|CDD\|227656	COG5353, COG5353, Uncharacterized protein conserved in bacteria [Function unknown].	1.34263e-38
NC_022524.1\|WP_022544121.1\|3077349_3077718_-\|YppE-family-protein	gnl\|CDD\|378052	pfam08807, DUF1798, Bacterial domain of unknown function (DUF1798). This domain is found in many hypothetical proteins. The structure of one of the proteins in this family has been solved and it adopts an all alpha helical fold.	8.1046e-47
NC_022524.1\|WP_022544124.1\|3080498_3083261_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NC_022524.1\|WP_035401134.1\|3085557_3086742_-\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NC_022524.1\|WP_009791239.1\|3070419_3071322_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	7.31051e-21

>NC_022524.1|WP_009791248.1|3077807_3078074_-|hypothetical-protein
MMKHTSQKEELLHMLNEIYDQLEELDAALETSLSKFRGEMAEEHQQKMIYCESRLANAENRLQEIGKKDGRDRKMTGGNDGIKLELGY
>NC_022524.1|WP_022544121.1|3077349_3077718_-|YppE-family-protein
MDEVKHLDRLTRELLECTEEAAGHYRQARERGTKPDFYAEVKPFADHSKQLLDEWSSQAARWIAENRPKNLHENQISSAAEHIELITVQCFFPETSRTRFINYYNSTKYVLNVLLGHLDEKK
>NC_022524.1|WP_022544120.1|3077059_3077266_+|hypothetical-protein
MNIHELRLKFLQLKDYSPESVNELLDFAKKAYIHNEITINEYRNLIRELEAQGAVADCSFTAAANLQN
>NC_022524.1|WP_083783064.1|3076323_3076776_-|hypothetical-protein
MQGSPQAQYQPQAFAGSQSAYFIPFQQAHNPPPYFQGYQHQMQPPIQPQVQPQAQQPVSQGLFQNPLQQEEAYQQPQSQQPHNPYPYMNPYPKQSFMAKQPSGVQSIMNSFKGQDGSLDFNKMMNTAGQMMSAVNQVSSMVKGLGGIFKV
>NC_022524.1|WP_009791244.1|3075308_3076172_-|ABC-transporter-permease-subunit
MLRQIQQLIIVVLLILLIASLPLMVTADPETQSLSFDPGALPQVYGEFFTQIADGDLGTYQQGTRTRSIGEDIGRFFITSLKIMEAGILAAVVLSLVFGVFISRFRAARGFNYILNILASIPDFIIIVASMILAVKFYKMTGIRIISLRPDSGALNTWFPTVLVAIAPTLYLFKLVAVKYYQLSGEDYIRTAVAKGMRLDYINLQHVFKNIEPFILAEMTKVISLGIGNLFIVEYIMNVSGITKFIFQANGFQPIAIGLFAMLLMSLIVYLSIRLLFYLFKRVLIHE
>NC_022524.1|WP_009791243.1|3072919_3075316_-|ABC-transporter-permease-subunit
MNKLLRVNYSLYIGVFLVSVLLFFAVFGPYLAPHQLSEALETQYRDGKVLAPPIQPFESGEYPLGTDRWGYDIASMILNGLKYTVFIAIAVTFIKMVLGTIIGLYVGTWKRTPGWLLAFENAWSFVPLFLIVYFFFRGINTLSFIPTWKLIMLFILITSLVSIPSIVSSVRQKTAELNKSVYIEAARALGAGRHRLIWKHIFPQLKETFLVMFILEIVYVITIMGQLGLLEIFVGGTRVTYDPLLFHSITKELAGLVGQARGNIYGNLHILMVPLAVLLITTISFSLLANGMKNRFQSNYQRTPWIKTGQEPKLKPVRKNYIAQKGRKLLSPEPMALIILLILFISAGTYVYATKDQDIGVKNFSQAEYDLSLKMNKQGEFSSTANIEVKNESEDEWDKLVFYFIPNVFKEGHSFQSVEGYASVTLNHIKVDGKEADYELKDDTLSVFLSEKMDKGDKGKVEINYEFTLPEKGNRFSKVDKNYYLAQWYPMLATFREHKWNKEKYSEGLETYHTDFSDYKVSYDIPKGYTIASTADEDPPASETRGTLKAEKVRDFFISILKDTKVYEAEAKEGVKVRLFTEDDHNKDPEQSLDLAKKALSFYQDKIGEYPHETLDVVLDEGQFMEYPGIVTINPYIEDSYFYQVSIVHEIAHQYFYGTVSNDPYYEAWVDEGITEFATSMYFYAGKGEGEIKAFSLPLNRMKSIEEESVKRQHSNVPLDEVSHNGYVYGQPAVKLLELVNNRFMVKGNDPRIVGMEFLSAYYEKFKFKEVDSKMFADFAADYFLVPKGYFTDWLTLE
>NC_022524.1|WP_009791241.1|3072324_3072804_+|Hsp20/alpha-crystallin-family-protein
MSSQLPDGPKKKEKNEPFSDIMKSMNTFFQEKPVKGFLQSIDDFFKTPFPQSSFSVRVSETDKEHHITAELPGIKREQIHIDVLDNYITISVSHAETVLQEDDKHRTFSRKQTMQQSSRTIPLPQPINEKKVRASYQDGLLIIRIPKQSGKKIIIDENN
>NC_022524.1|WP_009791240.1|3071318_3072236_+|peptide-ABC-transporter-permease
MNRKFQWKKYSVFIISLVCLGILAFIAFIGPFLPFIDRELSTITYIMDENRKPVIPPYGPNEDFPLGTDKSGRDLLSIIVLGAKETLLLVIIITALRYALAIPFAFLAHKKVLAADSVLKWLNGFLSYIPTIIIVILVVNLPPLLFAKDRPFWLILVVALSEAARAADMIKLEFDEVSSKEFITGGIAAGTTPFAMFKRYYMPFLYGKILVYMISDLGKVMFLLGQLGFVGIFISQQFVQTPTGLWEFVNTSISWPMLLKDAFIDIRGPIWIPFFAALFMTFSIFTFNLLSQGIKNIFARKIRYL
>NC_022524.1|WP_009791239.1|3070419_3071322_+|ABC-transporter-permease-subunit
MLLLKKLFIFLLVLASFLLILLLPREPVIYQPSAFHIEMDYPFSAEAYKNKIQSFFQFIQKENGFGESRTGRKVSEETILYMKRSLGIILPAFFISMAAGILAGIAKFSMRLRMRGKIQEALSWLFSSVPDFFLYMSLQYILIKLIQWGFPQITLYGHEHWYSFLLPMISLTLFPFIHMVNFTAAAMDKESGEDYIRTAYSKGLGKKKIYLHILFNCAGTLLNQAQFIMLYILSSLPIVEKLSGYEGAGNNLLKSILNYNDVSSFALMLPFLVLMFLTILASQSAKYLFMPKRAGGSELI
>NC_022524.1|WP_009791237.1|3067862_3070166_-|DEAD/DEAH-box-helicase
MKLRKNLQEILKDLKMTEEFKDNIVHWHTIEEKEAKTEDLPDDIHPSLRNALEKRGISRLYTHQRSAYAAASEGKSLVAVTPTASGKTLCYNLPVLQTAISDPKARALYIFPTKALAQDQKSEINELIQEAELPVNSYTYDGDTPANIREKVRKAGHVVITNPDMLHSAILPHHTKWVSLFENLKYVVIDEVHIYRGVFGSHVANVIRRLRRICRFYGSDPLFICTSATIANPLELAENLTEKKMELIDNNGAPSGRKHFLFYNPPIVNIPMNIRRSATLEARKLAGRLLKNRIQTIVFARSRVRVEILLTYLQELVKHQLGPKAIRGYRGGYLPTERRAIEKGLRAGEIYGVVSTNALELGVDIGQLQVCIMTGYPGSIASSWQQAGRAGRRHGESLVILVASSSPLDQYVIQNPDYFFNKSPETARINPDNLIILIDHMKCAAYELPFKYGEKFGTADTEELLEYLTEERVLYQNGDKWHWMNDSFPAHNISLRSASQENVIIIDQSDIANVKVIGEMDRFSAMTLLHDEAIYLHQGTQFQVEYLDWDEKKAYVREVDVDYFTDANLAVELKVLEEDKNRSRGEMEIGYGDVSVLAMATIFKKIKFETHENIGSGPIHLPQEELHTSSAWISIGKEQIQFDEDRIEEGLIGTAHALKHIAPLFVMCDPQDIFVVPQVKAAHNEKPTIFFYDRYPGGIGLSEKLYDGIETVIQKAEGMVAGCSCENGCPSCIGTDSAMNTAKSDVLKLLALFRKTAMEGERYEPQK
>NC_022524.1|WP_050767248.1|3078726_3079671_-|DUF2515-domain-containing-protein
MLAEEIRSIADHYNKDNISRTHAYFDYYQSHPDIQWAFLASMVSRNAGWNMCDLEEASLSCLLGPEIRERLFLTYERANWLIFSDAFPQLLLYEYSTKKNSPMFHLLPFFHVSSFMEKEWNRFWQEGDRERLMIALIINEQNLIQRPVIEHPVYKRRVFHSLFFSIQDWMHFSSVLFPTCSGQLYGASVKKFRKTDERIMLGKRLAGILFSPAHFPEFLNFAGKVPHTGSRLDYEQFLNGGTKRALQTLKDTYPVISHHIHEKHDWSKERGVSPEWFAEEGETEEPVLMTEWFLHKQRQLERAAGLKKFIWFKR
>NC_022524.1|WP_022544123.1|3079852_3080464_+|Holliday-junction-resolvase-RecU
MNFHYPNGRKYLPQKAAAAPVKKEKKWTYSNRGMTLEDDINETNAFYLERGLAVIHKKPTPVQIVNVDYPKRSAAVIKEAYFKQASTTDYNGLYKGRYIDFEAKETKNSTSFPLKNFHAHQISHMRRIVAQGGICFVLLRFSESEEIFLLEARSLFPFWERMENGGRKSIAKTEIEENGHRIQLGFQPRIDYIKVIDYLYNLT
>NC_022524.1|WP_022544124.1|3080498_3083261_+|PBP1A-family-penicillin-binding-protein
MAENYNSREERRKQQSAGTKKKTPKKKKGGIFKKIFLVLIALGLAGIIIGAGAFAYMVKDTPKLDEEKLKSAIASEIYDMNGEQIATIGSENRDYVEYEDIPKIVEEAVIATEDSRFYKHHGIDPIRLGGAVLANITEGFGAEGASTITQQVAKNYFLEFDKKLSHKAQEAWLAIQLERKYTKHEILELYMNKVNMSQYSYGFATASETYFGKPLKDLELHEAALLAGLPQSPNNYNPFNHPDKAEKRRNIVLTLMNKHGYITKEQMEAAKKIPVTSSLVAEENRKINGDIPYDSFIGQAIKEIDKKYPTINVFTDGLKIYTTLDKDAQEYVETMLNGNEIVEFPNEEFQAGITLLDTKTGEIRALGGNRNSDVEFGFNYATSHTRQPGSTIKPILDYGPAIEYERWGTYHTLDDKPYAYSNGTEFNNWDGRHMGPMSMREALARSRNVPAVMALQEVGLEKAKDFAVNLGIPLEDIQESYAIGGLKNGVTSMQMAGAYSAFGNNGIYNAPHTVKSVELRDGTKLDLTPESKAVMKDYTAFMITDMLKSVVKDSYGTGQQANVQGLPIAGKTGTTNYSSDEISKYNVPDGAVPDAWFAGYTTNYTAAVWTGYKDRKNYLPSNGRDQKIAQNLFKNLMAHVSEGKETPDFKMPKSVEVVKIEKGTSKLASAYTPSDQILTEYAVKGEAPTQVSKKYDKLDAPQGLSAVFDPEANEVVVGWEYGSEEGVQFEVNASVDGSGQQPTVTAEKGLRFTAPSPGSTYTFSVTAFRDDMRSDPASVSVTIPGAPEDDGQEEPEDGEDGSQDDDANQNDEENEEDNQNPGNGNGNGNGNGNGNGNGNGNGNGNGNGGNEEDDGEGDDSGSEGESGSGGESGQTGQNGGQSGSGSGTGSGSGGSGTGSGGSGSGSGSGSGSGSGSDGSN
>NC_022524.1|WP_022544125.1|3083299_3083830_-|hypothetical-protein
MADSEKIMLQVSPEVYHPFLVGEEEAWEPAWADEFQADAIFIYEIAFYNGIEALRPWEKAEEFFPARIEQWEEVKSSIAALHGKRERLGLAELMRSAIGIFVQMLFWTNGQPARLDTPKEFMLLNVKPANLNERLEFVLSSPLLYHSFIQLCELQAELEKQRQKKASIEKAFKHKA
>NC_022524.1|WP_009791255.1|3083829_3084477_-|endonuclease-III
MLNKTQIRHCLDVMGEMFPDAHCELHHENPFELVIAVALSAQCTDALVNKVTKNLFQKYKTPEDYLAVSLDELQNDIRSIGLFRNKAKNIHKLCRLLIDEYNGIVPHDRDELTKLPGVGRKTANVVVSVAYDVPAIAVDTHVERVSKRLGFCRWKDSVLEVEKTLMKKVPEEEWSVTHHRMIFFGRYHCKAQNPQCEICPLLDLCREGRKRMKRK
>NC_022524.1|WP_009791256.1|3084622_3085330_-|DnaD-domain-containing-protein
MKDNIIKWLQEGSLSIPGALLARYHKMNITEQELVLLLHISSFIEKGRDFPTPNEISSRMTISDTACTDMIRKLIQKGFIEILDGFSDEGIRFEKYSLEPLWERVVDQFLLEDKQKDLKSHQQEEMDLYTCFEKEFGRPLSPFECETLAMWMDDDHHDPVIIKAALREAVISGKLNFRYIDRILFEWKKNGIKTIEQAKSFGRKFRQNQPQSSRQKTDERPVQQKSIPFYNWLEQ
>NC_022524.1|WP_035401134.1|3085557_3086742_-|pyridoxal-phosphate-dependent-aminotransferase
MKLAGRVEALTPSSTLAITAKAKELKAQGRDVIGLGAGEPDFNTPQHIIDAALASMNEGNTKYTPSAGLPALRAEIAAKLKKDQGLDYKINETFVGSGAKHVLYTLFQVLLDEGDEVIIPTPYWVSYPEQVKLAGGIPVYAEGSEENGFKITPQQLKDAATEKTKAVIINSPSNPTGMLYTEEELKALGEVCLEKGILIVSDEIYEKLVYSNNRHVSIAQLSPELKEQTIIVNGVSKSHSMTGWRIGYAAGGSRIIKAMTDLASHSTSNPATASQYGAIAAYAGTQDPVEEMRQAFEGRLEEIYGKLVSIPGFTCIKPQGAFYLFPNARQAAEMTGYKDVDAFAEALLEEALVAVIPGSGFGAPDNIRLSYATSLESLEEAVERIRRFVAEKAQ
>NC_022524.1|WP_009791258.1|3086773_3087247_-|peptidase
MKKWIIISIIAAAILIGIAAKVYIASTEPVKAASEKAFERAKEETALERMDSFTLYHGQKTLYVLQGQDKAGTELIVWVPEKKGKPVVKNAKDGISKQEAIDIVKREKQPKEIISAKLGMEKGFPLWEVYYRSNGGLINYYYIHFETGEMLKRIENL
>NC_022524.1|WP_009791259.1|3087261_3087432_-|YpmA-family-protein
MESKIEVLSTVKITNSPDLYKIVDSLNRTLKEKDLMFGLALDQEDQNKAVFTIYRT
>NC_022524.1|WP_022544127.1|3087675_3088524_-|hypothetical-protein
MNMLFAFLMLFTSWYYVPVESPSLPAEVKSIDLKLKRNELAITFFSLQEGESALIQHPDGENILINTGGEGSGEELSRLLGLYNVEQISTIIMTEEDVNSMVNAGSIIREFGVKQLVAGQGLARKRMEELEEFDEVNIHIWSAGTKQQLFHNLKAEVLFENENPKEGMDLELTLMKHKVLLLNSSSLDAEKALLKKNLSDVNIVKMPGFGEGNSVSGQLIKHLDPQIAVIFQSRKVKPDEDLFKMLHEAWIDVYYTGVHGTVTIKFTDLNYEVITISPGEAG

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Crispr_ID: NC_022524_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_6

3640619-3640694

Orphan

Consensus_repeat	Method
TGGAATACATGACTTCCTTTTTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022524_6

>merge|NC_022524|6|3640619-3640694|CRISPRCasFinder
TGGAATACATGACTTCCTTTTTTTTTCACACTTATGTATCCCAGGTGCCTGATGGAATACATGACTTTCTTTTTTT

>NC_022524|6|5|3640619-3640694|CRISPRCasFinder
TGGAATACATGACTTCCTTTTTTT	TTCACACTTATGTATCCCAGGTGCCTGA
TGGAATACATGACTTTCTTTTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_009795334.1\|3637252_3637954_-\|DUF2953-domain-containing-protein	unknown	unknown	gnl\|CDD\|378578
NC_022524.1\|WP_022544279.1\|3641829_3643434_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|224490
NC_022524.1\|WP_022544277.1\|3638617_3639625_-\|signal-peptide-peptidase-SppA	unknown	unknown	gnl\|CDD\|132934
NC_022524.1\|WP_009795342.1\|3645615_3646821_-\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234960
NC_022524.1\|WP_009795335.1\|3638100_3638604_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NC_022524.1\|WP_009795344.1\|3648194_3649520_+\|branched-chain-amino-acid-transport-system-II-carrier-protein	unknown	unknown	gnl\|CDD\|283235
NC_022524.1\|WP_035403253.1\|3652420_3653050_-\|forespore-capture-DNA-binding-protein-RefZ	unknown	unknown	gnl\|CDD\|236928
NC_022524.1\|WP_009795346.1\|3651626_3652424_+\|histidinol-phosphatase-HisJ	unknown	unknown	gnl\|CDD\|236155
NC_022524.1\|WP_009795341.1\|3645308_3645512_-\|alpha/beta-type-small-acid-soluble-spore-protein	unknown	unknown	gnl\|CDD\|365990
NC_022524.1\|WP_009795345.1\|3649578_3651276_-\|septation-ring-formation-regulator-EzrA	unknown	unknown	gnl\|CDD\|377618
NC_022524.1\|WP_009795332.1\|3636103_3636604_-\|thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055
NC_022524.1\|WP_022544275.1\|3634962_3635949_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|223897
NC_022524.1\|WP_035403221.1\|3639769_3640573_+\|NAD-kinase	unknown	unknown	gnl\|CDD\|179584
NC_022524.1\|WP_009795338.1\|3640808_3641735_-\|EamA-family-transporter-RarD	unknown	unknown	gnl\|CDD\|225510
NC_022524.1\|WP_009795340.1\|3643582_3645169_-\|acyl--CoA-ligase	unknown	unknown	gnl\|CDD\|341276
NC_022524.1\|WP_009795343.1\|3646821_3647964_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NC_022524.1\|WP_009795328.1\|3632302_3633142_-\|EcsC-family-protein	unknown	unknown	gnl\|CDD\|378945
NC_022524.1\|WP_022544276.1\|3636745_3637234_-\|sporulation-protein-YtfJ	unknown	unknown	gnl\|CDD\|131921
NC_022524.1\|WP_009795330.1\|3633280_3634468_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NC_022524.1\|WP_009795327.1\|3631787_3632303_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	unknown	unknown	gnl\|CDD\|223595

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_009795334.1\|3637252_3637954_-\|DUF2953-domain-containing-protein	gnl\|CDD\|378578	pfam11167, DUF2953, Protein of unknown function (DUF2953). This family of proteins has no known function.	3.13977e-14
NC_022524.1\|WP_022544279.1\|3641829_3643434_-\|amidohydrolase	gnl\|CDD\|224490	COG1574, COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only].	4.51726e-176
NC_022524.1\|WP_022544277.1\|3638617_3639625_-\|signal-peptide-peptidase-SppA	gnl\|CDD\|132934	cd07023, S49_Sppa_N_C, Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad. Signal peptide peptidase A (SppA; Peptidase S49; Protease IV): SppA is found in all three domains of life and is involved in the cleavage of signal peptides after their removal from the precursor proteins by signal peptidases. This subfamily contains members with either a single domain (sometimes referred to as 36K type), such as sohB peptidase, protein C and archaeal signal peptide peptidase, or an amino-terminal domain in addition to the carboxyl-terminal protease domain that is conserved in all the S49 family members (sometimes referred to as 67K type), similar to E. coli and Arabidopsis thaliana SppA peptidases. Site-directed mutagenesis and sequence analysis have shown these SppAs to be serine proteases. The predicted active site serine for members in this family occurs in a transmembrane domain. Mutagenesis studies also suggest that the catalytic center comprises a Ser-Lys dyad and not the usual Ser-His-Asp catalytic triad found in the majority of serine proteases. Interestingly, the single membrane spanning E. coli SppA carries out catalysis using a Ser-Lys dyad with the serine located in the conserved carboxy-terminal protease domain and the lysine in the non-conserved amino-terminal domain.	1.29027e-99
NC_022524.1\|WP_009795342.1\|3645615_3646821_-\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234960	PRK01565, PRK01565, thiamine biosynthesis protein ThiI; Provisional.	0
NC_022524.1\|WP_009795335.1\|3638100_3638604_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	4.09969e-20
NC_022524.1\|WP_009795344.1\|3648194_3649520_+\|branched-chain-amino-acid-transport-system-II-carrier-protein	gnl\|CDD\|283235	pfam05525, Branch_AA_trans, Branched-chain amino acid transport protein. This family consists of several bacterial branched-chain amino acid transport proteins which are responsible for the transport of leucine, isoleucine and valine via proton motive force.	3.0483e-159
NC_022524.1\|WP_035403253.1\|3652420_3653050_-\|forespore-capture-DNA-binding-protein-RefZ	gnl\|CDD\|236928	PRK11552, PRK11552, putative DNA-binding transcriptional regulator; Provisional.	1.13825e-12
NC_022524.1\|WP_009795346.1\|3651626_3652424_+\|histidinol-phosphatase-HisJ	gnl\|CDD\|236155	PRK08123, PRK08123, histidinol-phosphatase HisJ.	3.11563e-145
NC_022524.1\|WP_009795341.1\|3645308_3645512_-\|alpha/beta-type-small-acid-soluble-spore-protein	gnl\|CDD\|365990	pfam00269, SASP, Small, acid-soluble spore proteins, alpha/beta type.	8.47111e-23
NC_022524.1\|WP_009795345.1\|3649578_3651276_-\|septation-ring-formation-regulator-EzrA	gnl\|CDD\|377618	pfam06160, EzrA, Septation ring formation regulator, EzrA. During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation.	0
NC_022524.1\|WP_009795332.1\|3636103_3636604_-\|thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	4.82149e-98
NC_022524.1\|WP_022544275.1\|3634962_3635949_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	1.21309e-42
NC_022524.1\|WP_035403221.1\|3639769_3640573_+\|NAD-kinase	gnl\|CDD\|179584	PRK03501, ppnK, NAD kinase.	0
NC_022524.1\|WP_009795338.1\|3640808_3641735_-\|EamA-family-transporter-RarD	gnl\|CDD\|225510	COG2962, RarD, Predicted permeases [General function prediction only].	4.84007e-97
NC_022524.1\|WP_009795340.1\|3643582_3645169_-\|acyl--CoA-ligase	gnl\|CDD\|341276	cd05972, MACS_like, Medium-chain acyl-CoA synthetase (MACS or ACSM). MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.	0
NC_022524.1\|WP_009795343.1\|3646821_3647964_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	5.76938e-175
NC_022524.1\|WP_009795328.1\|3632302_3633142_-\|EcsC-family-protein	gnl\|CDD\|378945	pfam12787, EcsC, EcsC protein family. Proteins in this family are related to EcsC from B. subtilis. This protein is found in an operon with EcsA and EcsB which are components of an ABC transport system. The function of this protein is unknown.	6.46609e-68
NC_022524.1\|WP_022544276.1\|3636745_3637234_-\|sporulation-protein-YtfJ	gnl\|CDD\|131921	TIGR02874, conserved_hypothetical_protein, sporulation protein YtfJ. Members of this protein family, exemplified by YtfJ of Bacillus subtilis, are encoded by bacterial genomes if and only if the species is capable of endospore formation. YtfJ was confirmed in spores of Bacillus subtilis; it appears to be expressed in the forespore under control of SigF (see ). [Cellular processes, Sporulation and germination].	1.23645e-60
NC_022524.1\|WP_009795330.1\|3633280_3634468_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NC_022524.1\|WP_009795327.1\|3631787_3632303_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	1.46906e-67

>NC_022524.1|WP_035403221.1|3639769_3640573_+|NAD-kinase
MKVTRRNLYFYHKKDSEMMEKAGHLYELAEKYGFTIVNDFKQANIIVSIGGDGTFLQAVRKTGFREDCLYAGISTTGTLSMYCDFHIDDTSKMVEAMANEQIEVRRYPTMEIKVDDESSFYCLNEFSIRSAIIKTFVMDVFIDNLHFETFRGDGMIVATPTGSTAYNKSVNGAIVDPMLPCLQVSELASLNNNRYRTLGSSFILSSGRSLTLRVIQDGNDHPTMGMDNEALSIQHVEKIEAKLSGKQIKTVKLKDNSFWEKVKRSFL
>NC_022524.1|WP_022544277.1|3638617_3639625_-|signal-peptide-peptidase-SppA
MNGKRWAALGIAAALLFFSIITSVLSTFAFRNAESTFADMFPVDEAFSEEIIEPGSSSKKIAVLNVDGTIQDAGDASSLFASPGYNHKSFMKKLDHVKEDDSVKAVILRVNSPGGGVVESSEIHDKIVEIQKEAKKPVYISMGSMAASGGYYISAPAEKIYASPETLTGSLGVIMQGYNYAGLAEKYGVEFVTIKSGPYKDIMSPSREMTEEEREILQSMIDNSYEGFVKVISEGRGIPADQVRKIADGRIYDGRQAKELNLIDGFGFFEDVVDELEKDHKLKGAQVVSYSENMGFGSLFSMGARKVMGDDIEMAGMMKLLSQPNAPRLMYMYSE
>NC_022524.1|WP_009795335.1|3638100_3638604_-|RDD-family-protein
MTTLDSHLDKDLPADNHSPASPSYEDHAASVRFAGFWMRFWAYLADLIVIGSINRIIVHPIFRAADLPLADSGIFTPANIVTSIIFYAYFVLMTKYFRQTLGKMIFGLKVVSLKDEEMSWSTILFREWIGRFISATIYIGYVIVAFLPKKQGLHDLFADTSVIHERK
>NC_022524.1|WP_009795334.1|3637252_3637954_-|DUF2953-domain-containing-protein
MWWLILGAAAAVILLLLIILLFSKLTVYFNFYHGQDNDHISIKFRAWLGLIRYNIQVPLIKIDDDSPSIVVEEKVEAGREEEKKQEDRKKFTPEDFLNSIKDAEELIRHVFGLHTIIRRFLKKVAIRDIEWHTLAGIGDAAHTAVLAGIIWSAKGSLVGILSHYMRMRDMPVLSVTPHFQAAVSQTRFSCMFQFRIGQAMLAGIKLIKYWKGGMPDFRTKPLSVLSDNKTKSV
>NC_022524.1|WP_022544276.1|3636745_3637234_-|sporulation-protein-YtfJ
MSDHPIQGLMTTAMENLKEMIDVNTIIGDPVETPDGSVILTVSKVGFGFAAGGSEFMLEGSGREGEGKPKHPFGGGSGGGVSITPIAFLIVSSHGVKMVHLDESTHLYEKILDLAPQAVDKIQQMMSKNNGSGNSSQDGKSEGQSSQNRSNEYNGPKHDLDF
>NC_022524.1|WP_009795332.1|3636103_3636604_-|thiol-peroxidase
MASITFKGNPVTLLGNEVKAGDQAPEFKVLANDLSEVTLADSKGQVRLISVVPSIDTGVCDAQTRRFNEEASKLDNVKVLTVSVDLPFAQKRWCAAAGIENVQTVSDHRDLSFGEAYGVAIKELRLLARAVFVVDSNDKVVYAQYVSEATDHPDYEAAVEAARQAE
>NC_022524.1|WP_022544275.1|3634962_3635949_-|class-I-SAM-dependent-methyltransferase
MSITPVEELFSVFNETAMILQEELQCTYLEALAETGDNIFQESILQDGLSELNVKRLKKSYESLNLDLYTSENIRKSFQLAILKGMKENVQPNHQMTPDAVGMLTGYLVNKFVGAKSFRLLDPAVGTGNLLTTVINQQEGKSIEAVGSDVDDLLIKLAYINANLQKHPIQFYNQDSLEPLFIESVDAVISDLPVGYYPNDIRAQDYELKADEGHSYAHHLFLEQSMRHVKEGGYLFLIVPNGLFESEQADKLKAYISKTSIIQGLLQLPETLFKNKNAAKSVFILQKKGEGVTAPKQALLVNMPSLSKTEQVERILKQVDAWFRENKI
>NC_022524.1|WP_009795330.1|3633280_3634468_-|acetate-kinase
MAKIIAINAGSSSLKFQLFEMPSEEVITKGLIERIGLNDAVFSISVNGEKQTEVTEIPDHEVAVKLLLNKLTDLKIIESLDEIEGIGHRVVHGGEEFADSAVITEEVLSKIDALSELAPLHNPANITGIKAFQQVLPNVPAVAVFDTAFHQTMPESSFLYSLPYEYYEKFGIRKYGFHGTSHKYVSERAAELLGRPLEQLRLLSCHLGNGASIAAIEGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKSADEVLNVLNKESGMLGVSGFSSDLRDIEVQASEGNERAELALEVFANRIHKYIGSYASRMYGVDAIIFTAGIGENSAEIRERVLQGLEFMGVYWDPALNKVRGEETFVNYPHSPVKVIIIPTNEEVMIARDVVRLAK
>NC_022524.1|WP_009795328.1|3632302_3633142_-|EcsC-family-protein
MALNGREEQALSEIAQWEDKLAQYESNDLELTYDKYLEKAFLLLPEKTQQQFFASLDNWLFHLHALIQSSQLQLDAKERILSAGRIFDAGIETVEDLASLDINQLQYIANQQIARHRLYSFAQGGASGTGGVLLLGSDLPAMAVINLRAVQLIAMTYGIEVNTPYEMMASLKVFCASILPPRLQGQAWDQLLAELENAEEAYFYEGQEELTDIAWMGQPIKQLFKGLAITAFKKKSIQGIPLVSMAIGAGANYQFTRKVTDFAHKYYQYRYLLKKQGEV
>NC_022524.1|WP_009795327.1|3631787_3632303_-|molybdenum-cofactor-biosynthesis-protein-MoaB
MSSEEHKKEAPKTVRCKIITISDTRNSETDKSGRLMKELLEAEGHRVSSYQIVADEKEKIRQAVLEGCSDPDIDAVLTNGGTGIALRDVTIETVSALYQKEISGFGELFRMLSYKEDIGSAAILSRASAGIIENTAVFSTPGSSGAVRLAMNKLIIPELGHVIREVKKDLV
>NC_022524.1|WP_009795338.1|3640808_3641735_-|EamA-family-transporter-RarD
MTDTEVKQGALYAGLSYLIWGILPIYWKLLNHVSADEILASRVFWSFIFMLAVLVLTRKWPDFVRTLRGIRNNKKQMLALTIASLLISCNWFIYIWAVNSGQMIEASLGYYINPLVSVLLGIVVLKEKLSSVQAVSFLLAAAGVLIMTLSYGRFPWIAVVLALSFGLYGLAKKLIKVESAIGLTLETMVVMPLALGYLIYLFAAGKQSFLAISTGTDLLLIGAGAATAIPLLYFAKGAQKIPLSMLGYLQYIAPTLTLLLGIFVYGEEFTKTHLVAFLFIWLALTVYSLSRTKLFANMKWKHGKGLGM
>NC_022524.1|WP_022544279.1|3641829_3643434_-|amidohydrolase
MRTLWHGGHIYTLQEEGHKAEAVMTENGKILRAGPLEDLKRNFSVKPSEMRDLEGRLMLPGFVDSHMHLIGHGERLIRLDLSGYTSKSQVLEAVKEYAGKFSKGSWVIGEGWNENLWDIPAPILAKELDEAVPGHPVCLKRICRHAIAVNSKALVAGGITPETICPPGGVIEKDEEGLPSGLLKDQAQELIFSILPGASKEYLETAMRAAIQDAYALGLTGAHTEDLNYYGGFHGTYRTFKEVIGEDKLPFRAHLLVHHEVINDMKLEGGNYLGGDEWIEFGAMKIFSDGALGGRTALLSHPYADDPSTSGVAIFTQDQLDGLLKKARELDMPVAIHAIGDRAFEMSLNSIEKYPLKGKGRDRLIHAQILRKELISRAKKLPLILDIQPRFLASDFPWVISRIGEEHMDYCYAWKTLLDEGIPCAGGSDAPIEQADPLLGIHSAVTRTSSDDPGRIAYIKEEALSMYEAVSLYTKGSAYAICHEVDRGMIKEGYLADFTILDRNIFEEDPEALLRTRVNETVIGGKTVYKRGQI
>NC_022524.1|WP_009795340.1|3643582_3645169_-|acyl--CoA-ligase
MKREDLLAPEKYNLVSEMEKFAEAPERTAILWESGEGERKEITYSRLLSNANKIGNVFFGSGLRQGDVVLIMVPRLIEAYQTYIAALKMGLVVIPCSEMLRSKDIQYRINHGDVKAIVCFSPFTEQFAGVTEAASLPKFVIGEPVPGWIPLDEKMEAASDIMETAGTNRDDMAFLSYTSGTTGNPKGVVHTHGWAYAHLRAAGPNWLCIKEGDTVWATAGPGWQKWIWSPFLSVLGSGGTGLVYSGKFEPKKYLALLQDYKVNVLCCTPTEYRLMAKVDNLAEYSLPDLHSAVSAGEPLNREVIDAFKKHFDIEVRDGYGQTENTLLVGITKGMELRPGSMGKPIPGNSVEIINEDGKACGPGEVGDIAVHIETPALFKNYYKDPERTAMQFRGEYYVTGDKAKKDEDGYFWFEGRGDDIIISSGYTIGPFEVEDALVKHPYVKECAVVASPDEIRGAVVKAFIVLQDGIAEDKPDLINTLQEHVKELTAPYKYPRRVEFLSELPKTTSGKIRRVELRKKEMEEAARS
>NC_022524.1|WP_009795341.1|3645308_3645512_-|alpha/beta-type-small-acid-soluble-spore-protein
MASSNNSNQLLVPGVQQALDSMKYEIATEFGVNLGAETTSRANGSVGGEITKRLVQMAEQQLGGFQR
>NC_022524.1|WP_009795342.1|3645615_3646821_-|tRNA-4-thiouridine(8)-synthase-ThiI
MNYDRILIRYGEISTKGRNRGKFVEKLKKSIKKVLHSYPAVRIEGQRDRMFIQLNGENGDEIIEKLKGVFGIQSFSPAVKTEKDIEKIKEAALALLKRVYKDGDTFKVSARRADKSFHLDTGELNHALGSHILKNMEGLKVDVKQPDINLQAEIRPEAAYLSCENIQGAGGMPAGSGGKAMLMLSGGIDSPVAGYLSMKRGLDVEAVHFYSPPFTSERSKQKVIDLAEKLAGYTGQMVLHIVPFTEIQQLIQKQVPENYTMTTTRRLMLKITDLVREKHGGLAVITGESLGQVASQTLDSMYAINEVTSTPVLRPLITMDKTDIIEIAQEIDTHDISILPYDDCCTVFVPASPKTKPKLDKAAYYESFVDFDALIAKAVEHIETIHIKPYEAGSGSEDDLF
>NC_022524.1|WP_009795343.1|3646821_3647964_-|cysteine-desulfurase
MIYFDNSATTKPYKEVLDSFNKVALDYFGNPSSLHGIGGRAEKLLSQARLQIAELLGAGQKEIFFTSGGTEGNNLAVKGTAMMHKSRGRHLITTESEHSSVAEAFEQLKELGFRVTYIPVDEDGRIRPEDIEAALCHDTILVSVIHVNNEVGTIQPIAEIGKMLKSYSKVLFHVDHVQGIAKVPLDFQENEIDLCTISAHKFHGLKGTGVLYIREGVKLSPLFSGGSQEWNQRSGTENVPGIVSMAKALRISLERHRIGLEQLNRVKCLLREGLESIEGISVHTPLEGSAPHILNFSAPGLKAEVFVHSLEEKNIYVSTTSACSSKKKSVSKTLLAMGIPEEDAASSIRISLSYDNTAEEAEAVLQAIEETAKKLRKVMK
>NC_022524.1|WP_009795344.1|3648194_3649520_+|branched-chain-amino-acid-transport-system-II-carrier-protein
MNNKSLSSREIIAIGLMLFALFFGAGNMIFPPYLGQESGVNMGKAIIGFLITGVGLPLLGVISIAKAGDLRTLAGRVHPLFGAAFTLLLYLAIGPLFGIPRTGTVAYEIGITPFLPDTVPKYGMALLFYTIIFFTVTAWLSMNPSKLVDRIGKLFTPILLAILAILAVKSIITPLGEPMAPKGAYAETPFFKGFIEGYLTMDAIAALVFGIVVIGSIKERGISSSKQIAKICIYSGLIAAAALMLVYLSLAYIGASGEESIGFQDNGGALLSAAASRLFGSFGAVILGLAITFACLTTSIGLVSSCAQYFSKVVPSISYRSFVLILSLFSMMIANIGLTQLISVSLPMLTMIYPPAIVLVLLSFLHHAFGGSRAVYAGALIPAGLISTIDAIKAAGADTRIFSDMLGFLPLYSEGLGWVIPAVAGGLLGLLIAGRGKKTAK
>NC_022524.1|WP_009795345.1|3649578_3651276_-|septation-ring-formation-regulator-EzrA
MEYIIGGIVIVIALFLTGYLMKKKYYKEIDRLEGWKMDITDRPVLDEMSKVKQLNMTGQTEELFERWRNEWDDIVTGQLPGVEELLFDAEEYIDRYRFKKAKEVQQAIEESLAGIEDKIKSLLAEINELVGSEEKNRTEIDGLKDLYRECKKALLAHRHTYGKAETILGIQLDEAFAKFQDFEDRTANGDYLQAREIVLTIQTQLDSIQKKMEAIPDLLVDAGSNIPSQLLEVREGFREMEQQGYMLEHVEVDKETESLEKEAAGYLAMIERGETGEAHEGLEDIKQRIDALYDLLEKEVYARKFIQSHDEKVRTELYNAKDANFMLKKELGIVQQSYHLQEKDEETHSLLETKLTKLFKRFEILEHKISNQSSAHSVLGEELEYIKNELEALSEEQVHFAEKLQALRKDELAAREKVKEISKKLSETIRLVSKSNIPGLSQNYRYLMEDTKESIQNVIEKLDEKPLDIPAVQQYLEIAVMTVDKAADSTAEMIETVQLAEKVIQYGNRYRSKYPSIAKALREAEDSFRNYNYKEALEQAASSIEEIEPGALKRIEDMIGEKENA
>NC_022524.1|WP_009795346.1|3651626_3652424_+|histidinol-phosphatase-HisJ
MLRDGHIHTPFCPHGSKDAFEEYIDRALSLGFAELTFTEHAPLPDGFTDTAPARDSAMQADDLEAYFEEISRVKALYKNKIKINAGLEVDFIEGFEKETGSFLSKVGHLLDDSILSVHFLYYDGQYDCADYSPDVFCSMISRYGSTEAVYRKYYETVRKSIAADLGPYKPKRIGHISLIHKFQKKYPAGFEDKQEISDILQLMKLHGYALDCNGAGTAKPLCREPYPPEWAASMAKSLGIQLVYGSDAHQAKELSQGFSSFPFEG
>NC_022524.1|WP_035403253.1|3652420_3653050_-|forespore-capture-DNA-binding-protein-RefZ
MKKNSKDAIVAAAISLFNTNGFTGTSIRDIAAKAKVNAANIAYYFHNKHGLLEHCFTEFFEGYIAEIEKGFSCLHLGAAAALKIISENILMYHSRNIHLTRFILREVSLDSQVVREIMSTYLMKEKYYLNKVFEIGMRAKEFRSQHPSYLIIQFKGLLSMPFLNMQYVSEVLHVFPNERYFADKYLIEIYNWIDGAVLEHAAREVVMAN

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Crispr_ID: NC_022524_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_7

3851789-3851862

Orphan

Consensus_repeat	Method
TTAACCGGAAAATCTCCGCTTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022524_7

>merge|NC_022524|7|3851789-3851862|CRISPRCasFinder
TTAACCGGAAAATCTCCGCTTATATAGACCCATTCATGGCATATTAACAATTTAACAGGAAAATCTCCGCTTAT

>NC_022524|7|6|3851789-3851862|CRISPRCasFinder
TTAACCGGAAAATCTCCGCTTAT	ATAGACCCATTCATGGCATATTAACAAT
TTAACAGGAAAATCTCCGCTTAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_009791458.1\|3858867_3859143_-\|DUF1027-domain-containing-protein	unknown	unknown	gnl\|CDD\|226876
NC_022524.1\|WP_022544344.1\|3843042_3843372_-\|YuzD-family-protein	unknown	unknown	gnl\|CDD\|377812
NC_022524.1\|WP_009791442.1\|3844739_3845801_-\|threonine-synthase	unknown	unknown	gnl\|CDD\|236013
NC_022524.1\|WP_009791441.1\|3843825_3844743_-\|homoserine-kinase	unknown	unknown	gnl\|CDD\|234920
NC_022524.1\|WP_009791440.1\|3843519_3843753_+\|NifU-family-protein	unknown	unknown	gnl\|CDD\|376458
NC_022524.1\|WP_022544345.1\|3852985_3853864_-\|foldase	unknown	unknown	gnl\|CDD\|234605
NC_022524.1\|WP_009791451.1\|3853922_3855152_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NC_022524.1\|WP_009791445.1\|3848593_3849559_-\|D-glycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240626
NC_022524.1\|WP_009791456.1\|3858210_3858477_+\|DUF3055-domain-containing-protein	unknown	unknown	gnl\|CDD\|378617
NC_022524.1\|WP_022544346.1\|3855318_3856083_-\|TIGR01457-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|130524
NC_022524.1\|WP_009791455.1\|3856739_3858044_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225110
NC_022524.1\|WP_009791454.1\|3856276_3856714_-\|DUF86-domain-containing-protein	unknown	unknown	gnl\|CDD\|225293
NC_022524.1\|WP_009791437.1\|3839871_3840111_-\|YuzB-family-protein	unknown	unknown	gnl\|CDD\|184226
NC_022524.1\|WP_009791443.1\|3845800_3847096_-\|homoserine-dehydrogenase	unknown	unknown	gnl\|CDD\|235783
NC_022524.1\|WP_009791449.1\|3852226_3852829_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|169051
NC_022524.1\|WP_009791459.1\|3859269_3859968_+\|sporulation-protein	unknown	unknown	gnl\|CDD\|378211
NC_022524.1\|WP_009791446.1\|3849668_3850676_-\|spore-coat-protein-YutH	unknown	unknown	gnl\|CDD\|131951
NC_022524.1\|WP_009791457.1\|3858546_3858837_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009791438.1\|3840454_3841522_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NC_022524.1\|WP_009791447.1\|3850874_3851381_+\|phosphatidylglycerophosphatase-A	unknown	unknown	gnl\|CDD\|224186

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_009791458.1\|3858867_3859143_-\|DUF1027-domain-containing-protein	gnl\|CDD\|226876	COG4470, COG4470, Uncharacterized protein conserved in bacteria [Function unknown].	3.57104e-46
NC_022524.1\|WP_022544344.1\|3843042_3843372_-\|YuzD-family-protein	gnl\|CDD\|377812	pfam07315, DUF1462, Protein of unknown function (DUF1462). This family consists of several hypothetical bacterial proteins of around 100 residues in length. The function of this family is unknown.	8.31508e-59
NC_022524.1\|WP_009791442.1\|3844739_3845801_-\|threonine-synthase	gnl\|CDD\|236013	PRK07409, PRK07409, threonine synthase; Validated.	0
NC_022524.1\|WP_009791441.1\|3843825_3844743_-\|homoserine-kinase	gnl\|CDD\|234920	PRK01212, PRK01212, homoserine kinase; Provisional.	1.99536e-109
NC_022524.1\|WP_009791440.1\|3843519_3843753_+\|NifU-family-protein	gnl\|CDD\|376458	pfam01106, NifU, NifU-like domain. This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.	2.0364e-30
NC_022524.1\|WP_022544345.1\|3852985_3853864_-\|foldase	gnl\|CDD\|234605	PRK00059, prsA, peptidylprolyl isomerase; Provisional.	2.26863e-38
NC_022524.1\|WP_009791451.1\|3853922_3855152_-\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	8.10703e-97
NC_022524.1\|WP_009791445.1\|3848593_3849559_-\|D-glycerate-dehydrogenase	gnl\|CDD\|240626	cd05301, GDH, D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH). D-glycerate dehydrogenase (GDH, also known as hydroxypyruvate reductase, HPR) catalyzes the reversible reaction of (R)-glycerate + NAD+ to hydroxypyruvate + NADH + H+. In humans, HPR deficiency causes primary hyperoxaluria type 2, characterized by over-excretion of L-glycerate and oxalate in the urine, possibly due to an imbalance in competition with L-lactate dehydrogenase, another formate dehydrogenase (FDH)-like enzyme. GDH, like FDH and other members of the D-specific hydroxyacid dehydrogenase family that also includes L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase, typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form, despite often low sequence identity. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	0
NC_022524.1\|WP_009791456.1\|3858210_3858477_+\|DUF3055-domain-containing-protein	gnl\|CDD\|378617	pfam11256, DUF3055, Protein of unknown function (DUF3055). This family of proteins with unknown function appear to be restricted to Firmicutes.	4.24817e-43
NC_022524.1\|WP_022544346.1\|3855318_3856083_-\|TIGR01457-family-HAD-type-hydrolase	gnl\|CDD\|130524	TIGR01457, HAD-SF-IIA-hyp2, HAD-superfamily subfamily IIA hydrolase, TIGR01457. This hypothetical equivalog is a member of the Class IIA subfamily of the haloacid dehalogenase superfamily of aspartate-nucleophile hydrolases. The sequences modelled by this equivalog are all gram positive (low-GC) bacteria. Sequences found in this model are annotated variously as related to NagD or 4-nitrophenyl phosphatase, and this hypothetical equivalog, of all of those within the Class IIA subfamily, is most closely related to the E. coli NagD enzyme and the PGP_euk equivalog (TIGR01452). However, there is presently no evidence that this hypothetical equivalog has the same function of either those. [Unknown function, Enzymes of unknown specificity].	1.03884e-135
NC_022524.1\|WP_009791455.1\|3856739_3858044_-\|EAL-domain-containing-protein	gnl\|CDD\|225110	COG2200, Rtn, c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms].	3.48796e-58
NC_022524.1\|WP_009791454.1\|3856276_3856714_-\|DUF86-domain-containing-protein	gnl\|CDD\|225293	COG2445, COG2445, Uncharacterized conserved protein [Function unknown].	3.8571e-30
NC_022524.1\|WP_009791437.1\|3839871_3840111_-\|YuzB-family-protein	gnl\|CDD\|184226	PRK13669, PRK13669, hypothetical protein; Provisional.	3.66925e-50
NC_022524.1\|WP_009791443.1\|3845800_3847096_-\|homoserine-dehydrogenase	gnl\|CDD\|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	0
NC_022524.1\|WP_009791449.1\|3852226_3852829_+\|uridine-kinase	gnl\|CDD\|169051	PRK07667, PRK07667, uridine kinase; Provisional.	4.50156e-94
NC_022524.1\|WP_009791459.1\|3859269_3859968_+\|sporulation-protein	gnl\|CDD\|378211	pfam09580, Spore_YhcN_YlaJ, Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ). This entry contains YhcN and YlaJ, which are predicted lipoproteins that have been detected as spore proteins but not vegetative proteins in Bacillus subtilis. Both appear to be expressed under control of the RNA polymerase sigma-G factor. The YlaJ-like members of this family have a low-complexity, strongly acidic, 40-residue C-terminal domain.	3.75965e-35
NC_022524.1\|WP_009791446.1\|3849668_3850676_-\|spore-coat-protein-YutH	gnl\|CDD\|131951	TIGR02905, conserved_hypothetical_protein, spore coat protein YutH. Members of this family are homologs of the Bacillus subtilis spore coat protein CotS. Members of this family, designated YutH, are found only in the family Bacillaceae from among the endospore-forming members of the Firmicutes branch of the Bacteria. [Cellular processes, Sporulation and germination].	7.65463e-179
NC_022524.1\|WP_009791438.1\|3840454_3841522_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	2.84781e-118
NC_022524.1\|WP_009791447.1\|3850874_3851381_+\|phosphatidylglycerophosphatase-A	gnl\|CDD\|224186	COG1267, PgpA, Phosphatidylglycerophosphatase A and related proteins [Lipid metabolism].	4.87223e-54

>NC_022524.1|WP_009791447.1|3850874_3851381_+|phosphatidylglycerophosphatase-A
MSEEQKEVVDLTEQTARRWLLERGVTVQDIADLVFFLQEKYHPNLEMKDCLHNVERVLSKREVQNAILTGIQLDMLGEKGMLDQPLQKIIETDESLYGVDEVLAFSIVNVYGSIGFTNYGYIDKLKPGILKDLNDKSSGKCHTFLDDIVGAIAAAASSRLAHGAAKVE
>NC_022524.1|WP_009791446.1|3849668_3850676_-|spore-coat-protein-YutH
MLRQMLKQHFGIQAEEELRIGLHEAFKKDNQLYIPMEVGLEEEDLAELSLIASHLQQTGDKTVSTFLQTTEGKHSSVWEQKSYCVLKCPNAQPRKGYQSGRKLAKFHYRGRLISSPITRTSRIGQWKQLWEKRLDQMEKVWNSMLFQQPEHELDRMFLETFPYYMGLAENSIQYLADAELDDEPGPADSGTVCHERFVSSTWGSDDYLIKSPFDWVFDHASRDLAEWSRERYFRNIKTYQPGLSQYLKEYQTVEPLTSFSWRLLYARLLFPLHYFECIENYYGNPTEHQRHLSEEQLGRFLQHTGDHEEFLGKFFEMAEVPAAKMKLPPVDWLKR
>NC_022524.1|WP_009791445.1|3848593_3849559_-|D-glycerate-dehydrogenase
MKDRVYITRKLPEETISGLKEHYHVEMWDKEDIPVPAEVLREKAKEASALLTMLSDSIDGDLLAEAHRLKVVANLAVGYDNIDVKAAAEKGITVANTPDVLTDTTADLTFALLMAAARRITESAEYVKEGKWKSWSPLLLAGQDIHHKTIGIVGMGNIGQAVAKRAKGFDMNILYHNRSRRPEAEEKLGAVYASFEELCEQSDYVVCLAPLNESTKNLFTEEAFRRMKNSAIFINAGRGAIVDEDALYRALLDGEISGAGLDVFVKEPIGKDHPLLSLSNVVALPHIGSSSTETRMEMARLCAENINLVLSGKQAKTPVHI
>NC_022524.1|WP_009791443.1|3845800_3847096_-|homoserine-dehydrogenase
MEAISVGLLGLGTVGSGVVKIIKNHQDKLMHQVGCPVEVKKVLVQDLNKQREVDIEASLLTGSPEEIIDNPDIDIIIEVMGGIEDTRKHLLKALANKKHIVTANKDLMALYGSELLTAASENGCDLFYEASVAGGIPILRGLADGLASDRITKMMGIVNGTTNYILTKMSQDGSAYEDVLKEAQELGYAESDPTSDVEGLDAARKMAILATLGFSMKVDLVDVKVKGITGVTEEDLQYGKQLGYIMKLIGIAHREGEKVEVSVQPALLAESHPLAGVNNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVGVMKNLRLGVNGKSAVSPQYPKKLKDPSEIYSKYFLRLHVKDEVGVFGELTSIFSKHSVSLEKILQLPVEEKGLAEIVLVTHQSSLKDYEDILSSLEDLPAVKTIESSYRVEGSGS
>NC_022524.1|WP_009791442.1|3844739_3845801_-|threonine-synthase
MRWEGLLSAYKEYLPVNDETPMLSLNEGNTPLIKLNRISQEWGIELYVKTEGSNPTGSFKDRGMVMAVAKAKEAGSSTVICASTGNTSAAAAAYAARAGMRCIVVIPEGKIAMGKLAQAIMYGAEIISIEGNFDEALAMVRSISETEPVTLVNSVNPYRLEGQKTAAFEICDQLGSAPDILAIPVGNAGNISAYWKGFKEYNRAKQTGLPRMFGFEAEGAAAIVHDRIFAEPETIATAIRIGNPASWQLAVDARDESEGKIDEVSDTEILGAYRKLAASEGIFAEPASCASLAGIYKKLRQGEIPHGSRVVAVLTGNGLKDPNTAIDTSLVKPILLPNELEAVAGHIRGAVHT
>NC_022524.1|WP_009791441.1|3843825_3844743_-|homoserine-kinase
MMEGEMLTIRVPASTANLGPGFDSVGLALSLYLTVEAERAGQWEVVPESSCLEGFPRDSRHLIVQAAKKAAEHYSADLPPCILRVKSDIPLARGLGSSGAAIVAGIELADSLCGLGLSRHEKLSIAGRMEGHPDNVGASLFGGLVIGYQTGEEVLAAAFQHLGIEVLAVVPQEELLTKESRGALPASLTHQESVQAGAAANLLIAALLQGNYELAGKMMQKDLYHQPYRRKLVPHLDMIEEKAAALGVFGTALSGAGPAVVCFIAPEKGDQAADALSRILPQMDVLRLSIDQKGSTVSRHAVSGR
>NC_022524.1|WP_009791440.1|3843519_3843753_+|NifU-family-protein
MEQDIISDVQEVLDKLRPFLLRDGGDCELVDVEDGIVKLRLLGACGSCPSSTITLKAGIERALLEEVPGVVEVEQVF
>NC_022524.1|WP_022544344.1|3843042_3843372_-|YuzD-family-protein
MDRRSVEIVVYGAEQLCPSCVNLPSSKETYEWLEAAVSRKFADQPFSISYVDIHNPPDDEAKRDFAMRVIEEDMFYPVVLIGDEVVGEGNPKLKTIFAKMEDCGYTPAS
>NC_022524.1|WP_009791438.1|3840454_3841522_+|NAD(P)/FAD-dependent-oxidoreductase
MKNLVILGGGYGGMRALARLLPNSLPEDTSITLIDRVPYHCLKTEYYALAAGTISDQHVRVAFPEHPRLKIKYGEISGIDLEKQQVNLANETPVSYDDLIIGLGCEDKYHNVPGADVHTYSIQTIEKSRRTYETLNNLSPGSVVAIVGAGLSGVELASELNESRPDLKVKLFDRGNHILSAFPERLSTYVENWFDNHGVEIINNSNITRVEENILYNHDEPLQCDAIVWTAGIQPSKVVRDLPVEKDAQGRVVLTKHHNIPGNEHVYVVGDCASLPHAPSAQLAEGQAEQIVQILLKRWKGEELPESLPVIKLKGVLGSLGKKHGFGLVAERPITGRVARLLKSGILWMYKYHNG
>NC_022524.1|WP_009791437.1|3839871_3840111_-|YuzB-family-protein
MIQPIIEFCISNLASGAQKALEILEKDPDLDVIEYGCLGYCGKCASSLYALVNGEVVTGETPEELVENIYQFLDENPMF
>NC_022524.1|WP_009791449.1|3852226_3852829_+|uridine-kinase
MDINHLKQAIEKGLQNDRFILGIDGLSRSGKTTLVNRLKQWLQAEGHPAVIFHLDDYIEDRNKRYNTGNEEWYEYYFLQWDAEYLKQELFSKVHTGTELTLRFYVEQNDSHFLKNTTIPRKCLIIIEGVFLQRPEWRNHLDYIVYLDCPRETRFKREKEATRQKVDKFENRYWKAEDHYLETVRPLEGADLVVSQPVQPV
>NC_022524.1|WP_022544345.1|3852985_3853864_-|foldase
MGFLTKKIGLGILVLILAAAGTAAFFLSKEPAVASVGSESIKKEELYSLLVKQYGDEALDALVTDKIIEMEAKKEKVTISNKEKEEELKNLKESYGGEEGFKAALEQSGVTEAGIAEDIEKYLKTEKLLEPRIDLKEDEIKAYFEENKDQFAQQEQVKASHILVEDEATAKEVKSKLDKGEEFADLAKEYSTDASNAESGGELGYFGKGEMEAAFEEAAFELKANEISGPVKTDYGYHIIKVEDKKEAKEAVYEDSKEAAKKALFDERMQTEYYNWLEEKKEEYKIEKNMNA
>NC_022524.1|WP_009791451.1|3853922_3855152_-|PDZ-domain-containing-protein
MMDSNDKYNQEETKSKLRKGKGILSVVAAGVIGSALTLYAAPYTDYIRDQFPQAAASQDVSGGQASSTADANKTGIIPEQTSAHTEGSLADIVEGASKAIVGIVKSENRANQFSNTSQTVESGSGSGVIFKKENGSAYILTNNHVVEGASKIDISLHDGQKTTAELVGADALTDLAVLRMDEKYADTLLGFGDSSKLRPGDQVLAIGNPLGLDLSRTVTQGIVSAVDRSISVDTSAGSWDMNVIQTDAAINPGNSGGALINTAGEVIGINSLKISESGVEGLGFAIPSNDLQPIVEEIMANGKVERPYAGVGLAGLQEVPQGYLQNLPQDVTKGAFIANIDPESAAAKAGLKTGDVIIAINDTEIGSPDDFRKYLYTKLKTGDKAELSLYRNGEKMNITMELGTKTITD
>NC_022524.1|WP_022544346.1|3855318_3856083_-|TIGR01457-family-HAD-type-hydrolase
MKDYKGYLIDLDGTMYRGTELIQEAADFVKKLKERGIPYLFVTNNSSRTPQQVAAKLRDFDIPAEEEQVFTTSMATASFIAEEKKDASVYVIGEEGIRTAIEDEGLSFANEDADYVVVGIDRSINYEKLAIGCLAVRRGAKFISTNGDIALPTERGFLPGNGSITSVITVSTQTEPLFIGKPESIIMEQALKVIGTSKDETLMVGDNYDTDILAGMNAGMDTLLVHTGVTTKELLEGYEKKPTYVMDSLDQWKF
>NC_022524.1|WP_009791454.1|3856276_3856714_-|DUF86-domain-containing-protein
MYFVDREKIEEILVFFEKQTALFEGKDNWDSEIERAALERVSHLLIEAILDVGNSIIDGFIMRDPGSYEDIVDILEDEKVISSDMAGSYKAIIQYRKELVQNYTSISHTELQKAFTDHLDDIKRFAPAVRSYILNELGPVSAFKN
>NC_022524.1|WP_009791455.1|3856739_3858044_-|EAL-domain-containing-protein
MVHKSRQKLRNFFNWGKIVFPLSSIRYYPPQFILRDPIIQGVKRAFRKGSEVAVAVFTIKNLREISDQLGQTGYFAYISSIKREFCHTIQGELKEEEVILLHDHYSDGLTLFIEVGHERYCISEIEGIMKKILRESERNLLLSHPAVNPQIETGYMFIEKKHYSIEEAVLKAHQQALAMAEKRVQSDFNEMLYSMSKIVAKKEIRLLAQPILDVATKEVKAWEMLTRGPEGTPLENPLQLFSVARQTGMLYDLEMIVMEKILEQIETTGCQQDIFINFTPITLGNQLFVRDIKKLLARHKGISPRQMTIEVTERDSIEGMEYFIYNIKVLRTLGFRIAIDDTGAGYASLNSITEIMPDIIKIDRSVIQNIDKNTVKESMLKGLLLVAKETGSLVVAEGIESEEEAIVLFRNKVDLAQGYFYARPDLLQKGLLSS
>NC_022524.1|WP_009791456.1|3858210_3858477_+|DUF3055-domain-containing-protein
MSERFFLYDDLEETKTRFVSFMGENQRFDLAIIQSSRYYGKQLVLDIQGSRFAIIGPDDLKEEGYLEFAFKLSEEDAEELRSFLYEMI
>NC_022524.1|WP_009791457.1|3858546_3858837_+|hypothetical-protein
MSDDKEKETYTDFSNVETQRNFLVPETLPEGPYGSPRGKDQPVENKSTPWREGQRYYSAFNYEFKSLHQNLPRQMEGAHPTHDDPDKNEEPPYTSK
>NC_022524.1|WP_009791458.1|3858867_3859143_-|DUF1027-domain-containing-protein
MVCINNICYELIEERTDGFNEEAFRGRYSEILTKYDYIVGDWGYGQLRLRGFFDDQNQKATFDTKISTLTEYLYEYCNFGCPYFVVKKIKA
>NC_022524.1|WP_009791459.1|3859269_3859968_+|sporulation-protein
MKKSIIIIGICSLSALAACQNFSSKDEMYEESGNTINVNDQRPELYNQNYRRGNNMSESYGYVRHQRSPIPGDNSSNDHYAAINREQVADIIAKYCTDVPNVDDVSALVTDEEVLLVYDTDSKDRAETADQVKKMAMSVIPRWYHVYVSDNTNLRKNVENYATMDSDSRNMEYAINETIKEMLQSPQGRKMSSGENENGEAQGEMNDDTDHDDISEALDKTKAKKGSSPQMK

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Crispr_ID: NC_022524_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_8

4233160-4233221

Orphan

Consensus_repeat	Method
GGGTCAGGTCCCTTGGCTCGTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022524_8

>merge|NC_022524|8|4233160-4233221|CRISPRCasFinder
GGGTCAGGTCCCTTGGCTCGTTTTCGCGGTGGAGCCAGGGGGTCTGGCCCCTTGGCTCGTTG

>NC_022524|8|7|4233160-4233221|CRISPRCasFinder
GGGTCAGGTCCCTTGGCTCGTTT	TCGCGGTGGAGCCAGG
GGGTCTGGCCCCTTGGCTCGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_022544446.1\|4242861_4243353_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009792825.1\|4243770_4245081_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377990
NC_022524.1\|WP_009792843.1\|4225274_4225535_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009792831.1\|4234876_4235590_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_022524.1\|WP_009792835.1\|4230212_4232144_-\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_022524.1\|WP_009792833.1\|4233483_4233714_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009792837.1\|4229217_4229763_-\|PTS-sorbitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|367578
NC_022524.1\|WP_009792830.1\|4235691_4237101_-\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NC_022524.1\|WP_022544444.1\|4234011_4234863_-\|ROK-family-protein	unknown	unknown	gnl\|CDD\|366120
NC_022524.1\|WP_009792838.1\|4228189_4229197_-\|PTS-glucitol/sorbitol-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|226255
NC_022524.1\|WP_009792824.1\|4245254_4246139_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|132912
NC_022524.1\|WP_009792834.1\|4232231_4233032_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|180439
NC_022524.1\|WP_022544445.1\|4239470_4241393_-\|transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NC_022524.1\|WP_009792836.1\|4229767_4230208_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369138
NC_022524.1\|WP_009792827.1\|4241645_4242593_-\|mannose-6-phosphate-isomerase,-class-I	unknown	unknown	gnl\|CDD\|224399
NC_022524.1\|WP_009792841.1\|4226279_4226942_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319859
NC_022524.1\|WP_009792840.1\|4226964_4227648_-\|fructose-6-phosphate-aldolase	unknown	unknown	gnl\|CDD\|188643
NC_022524.1\|WP_009792842.1\|4225896_4226205_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009792829.1\|4237379_4239320_-\|PTS-transporter-subunit-EIIA	unknown	unknown	gnl\|CDD\|224218
NC_022524.1\|WP_022544443.1\|4227718_4228081_-\|PTS-glucitol/sorbitol-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|367683

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_009792825.1\|4243770_4245081_+\|hypothetical-protein	gnl\|CDD\|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	1.26752e-17
NC_022524.1\|WP_022544444.1\|4234011_4234863_-\|ROK-family-protein	gnl\|CDD\|366120	pfam00480, ROK, ROK family.	3.79713e-80
NC_022524.1\|WP_009792831.1\|4234876_4235590_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	3.97675e-76
NC_022524.1\|WP_009792835.1\|4230212_4232144_-\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	1.19527e-29
NC_022524.1\|WP_009792837.1\|4229217_4229763_-\|PTS-sorbitol-transporter-subunit-IIC	gnl\|CDD\|367578	pfam03608, EII-GUT, PTS system enzyme II sorbitol-specific factor.	1.51524e-98
NC_022524.1\|WP_009792830.1\|4235691_4237101_-\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	0
NC_022524.1\|WP_009792838.1\|4228189_4229197_-\|PTS-glucitol/sorbitol-transporter-subunit-IIB	gnl\|CDD\|226255	COG3732, SrlE, Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism].	1.90786e-166
NC_022524.1\|WP_009792824.1\|4245254_4246139_+\|GAF-domain-containing-protein	gnl\|CDD\|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	2.11942e-33
NC_022524.1\|WP_009792834.1\|4232231_4233032_-\|SDR-family-oxidoreductase	gnl\|CDD\|180439	PRK06171, PRK06171, sorbitol-6-phosphate 2-dehydrogenase; Provisional.	1.20218e-143
NC_022524.1\|WP_022544445.1\|4239470_4241393_-\|transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	1.54579e-57
NC_022524.1\|WP_009792836.1\|4229767_4230208_-\|hypothetical-protein	gnl\|CDD\|369138	pfam06923, GutM, Glucitol operon activator protein (GutM). This family consists of several glucitol operon activator (GutM) proteins. Expression of the glucitol (gut) operon in Escherichia coli is regulated by an unusual, complex system which consists of an activator (encoded by the gutM gene) and a repressor (encoded by the gutR gene) in addition to the cAMP-CRP complex (CRP, cAMP receptor protein). Synthesis of the mRNA, which initiates at the promoter specific to the gutR gene, occurs within the gutM gene. Expressional control of the gut operon appears to occur as a consequence of the antagonistic action of the products of the autogenously regulated gutM and gutR genes.	1.38182e-44
NC_022524.1\|WP_009792827.1\|4241645_4242593_-\|mannose-6-phosphate-isomerase,-class-I	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	5.69108e-140
NC_022524.1\|WP_009792841.1\|4226279_4226942_-\|HAD-family-hydrolase	gnl\|CDD\|319859	cd16423, HAD_BPGM-like, uncharacterized subfamily of beta-phosphoglucomutase-like family, similar to uncharacterized Bacillus subtilis YhcW. This subfamily includes the uncharacterized Bacillus subtilis YhcW. It belongs to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), Saccharomyces cerevisiae phosphatases GPP1 and GPP2 that dephosphorylate DL-glycerol-3-phosphate and DOG1 and DOG2 that dephosphorylate 2-deoxyglucose-6-phosphate, and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	5.2613e-58
NC_022524.1\|WP_009792840.1\|4226964_4227648_-\|fructose-6-phosphate-aldolase	gnl\|CDD\|188643	cd00956, Transaldolase_FSA, Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea. Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea, which are member of the MipB/TalC subfamily of class I aldolases. FSA catalyze an aldol cleavage of fructose 6-phosphate and do not utilize fructose, fructose 1-phosphate, fructose 1,6-phosphate, or dihydroxyacetone phosphate. The enzymes belong to the transaldolase family that serves in transfer reactions in the pentose phosphate cycle, and are more distantly related to fructose 1,6-bisphosphate aldolase.	1.7403e-82
NC_022524.1\|WP_009792829.1\|4237379_4239320_-\|PTS-transporter-subunit-EIIA	gnl\|CDD\|224218	COG1299, FruA, Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism].	2.21324e-134
NC_022524.1\|WP_022544443.1\|4227718_4228081_-\|PTS-glucitol/sorbitol-transporter-subunit-IIA	gnl\|CDD\|367683	pfam03829, PTSIIA_gutA, PTS system glucitol/sorbitol-specific IIA component.	1.15288e-54

>NC_022524.1|WP_009792834.1|4232231_4233032_-|SDR-family-oxidoreductase
MSGSWLGLEEKVAIVTGGASGIGLHITNELLKNGVKVVIADLNGEEGEQENGSYFIQCDVTKKESVDQAVAKTVELFGSLDILVNNAGVNLPRLLVDDKGEKPEYELSEKDFDFMVAVNQKGPYLFAQASAKKMLQQNGGVIINVSSEAGQEGSAGQSCYSATKGAVIAFTRAWAKELGKHNIRVVAIAPGIIETTGLRTDAYNEALAYTRGVTVDGLSTDYSKSIPLGREGMLTEIADLVSYLASDRAGYVTGTTFNISGGKSRG
>NC_022524.1|WP_009792835.1|4230212_4232144_-|BglG-family-transcription-antiterminator
MSDRMIDERAAKMLAIARTKTYHSLDELAEAMGVGTRTIRNYIKQLNEDLNGIASFFNERGKGFRFDINNMKAFQSYLEESSPEDSSLNSQKGRIGFIIDRLINSEETYTLDDLAEEMHLGRTTLVNELKKAAVSLETYKLIIHGKPNRGMELSGRELDLRFYILDHLYDVLYGDYPLDEDITESIERISHEYNLESPTQERLMEFIIIMLDRLLKNHHLEAIEEKHKKLIGTQEHGIALEIVEAIQKQLPIEIPEAEALFITIPIAGRRTPTNNRTLADIAITDDVRRLLEQILEQVGFKKEIIEQNESFFQDLLYHLTFMLNRLIFGLRLKNALLANVKEKYPVAYKMAEISGQVIESRYGLEVPEDELGYLAFYFGVFIGQSDIKVKRFQKAAVVCGTGRGTAKLVSIQLERILNQDTEINLFAEKDAVKEVLDSYDLVFSTVKLPFETHAPFIMINEIFDESRVKREIEKAAYRQRLNIQNGSEYQSVMAQLLAKESFFQLDSSKGYHENVFHMVNELTEIGRLDLGFLERLKEREEKGSMVFDRYIAFPHTFNQQSNDIELAVGIFPEGVMENGREVRLVFLLGLPEEQNECNESLIVKIYDEIIGIANNEELIAQLVEAASYEDFVSSIERSNRERG
>NC_022524.1|WP_009792836.1|4229767_4230208_-|hypothetical-protein
MILFLIILIGIAWLVQSILGFFQIKHFNKKYAEMRSLGRVAIGKRTGKLRAGTVVMFAIDKRNKILKAAKMQGVTVFSKVKDLNGFEGKYLLKISDEDFKGHDKLTQLAIADALKSYDIISKGGELQVKKGWIDYIMPKKKEMRRG
>NC_022524.1|WP_009792837.1|4229217_4229763_-|PTS-sorbitol-transporter-subunit-IIC
MDFIIKLAEGFMNLFRTGGETFVSLVTDIVPLLIMLLVAMNALVRLVGEERVEKLARKSGKNAFTRYFVLPIIGTFVLANPMTLSLGRFLPEKYKPSYYAAASYSCHTHNGLFPHVNPGELFVFLGISAGITTLGHDVTELALRYFLVGIFTNFLRGWITDLTTSYVAKQQNVKLKDTVQL
>NC_022524.1|WP_009792838.1|4228189_4229197_-|PTS-glucitol/sorbitol-transporter-subunit-IIB
MTAFQSIKISKGAGGFGGPLVITPTDEKNKVVYITGGQRPEIADKIAELTGCELVDGFKTSVPEKEMACVIIDCGGTLRCGLYPQKRIPTINIMPTGQSGPLAKHITEDIYVSGVKAENIQLADAEGAAAPAMSVQEETAEGIKTPKYSSDKKISEQQKPKGLMARVGMAMGSITSVFYQAGRDAIDTVIKTILPFMAFVAMLIGVILESGIGDVFAKFLSPFAGSVWGLIVIALVCSFPLLSPFLGPGAVIAQVVGTLIGVEIGKGNIPAHLALPALFAINAQAAADFVPVGLGLAEAEVETVEVGVPSVLYSRFLTGAPTVFIAWLASFGLYD
>NC_022524.1|WP_022544443.1|4227718_4228081_-|PTS-glucitol/sorbitol-transporter-subunit-IIA
MTTKFETKINSIGPSVTEFFGEKMFILFGDNAPAELAEYCLLIDVKGVEGEIAAGDTLQIGCNEYKVTSVGDAVKQNLSSLGHITLKFDGSQNPELPGTLYLEDSEIQEVNAGDTIRIYS
>NC_022524.1|WP_009792840.1|4226964_4227648_-|fructose-6-phosphate-aldolase
MRLVIDSANIESIKKLVEYFPIDGVTTNPSIVVKEQKPFLPLLKEIRAVIGEEKELFAQTIAGDAEGMGEEARWLCEAVSGNVVVKIPVTMEGIKAIKMLKAEGIRTLATTVYTPMNAYLAAKAGADYVAPYVNRIDNLTGNGAKVVAEITEIFSKHNLSCEILAASFKNVQQIHNVCLAGSHGITASPELIEALVNIPSIEDNVKAFRQDWMGQYGEGSLILSEDK
>NC_022524.1|WP_009792841.1|4226279_4226942_-|HAD-family-hydrolase
MIKAIVCDFDGLIIDTEYALYEAFCDMLAIDHSEMPIADYAHFIGTDSKGLYEYIMEKSNGTMTIEEIIERSHILHKEKLQSPIAREGVEDYLKEAKSRGLKIGLASSSNREWVTFFLKKLNFLQYFDYIQTSDDVEKVKPDPALYRNVISHFGIEPSEAIAFEDSMNGSKAAIAAGLRCVIVPNKITENLAFEGYHMRLGSMGEKEFGRVVKEIERLER
>NC_022524.1|WP_009792842.1|4225896_4226205_+|hypothetical-protein
MKGDQIREKGKTRFVLQFSLGISIPLLIDYYIIKFLLHSFEMDFVFAEGLIAWIICLLVGGIRQVCLGEFGEGQRIIGPIPCQGLFQRMIKSLMSSTYQLLL
>NC_022524.1|WP_009792843.1|4225274_4225535_-|hypothetical-protein
MKRMYVLLSFLLFLLLCFMYPLIIFMAMNGAFGAFGEFTVFLWPVFPILGVLSAIFGGKGRIKVAGIMLNGTALCLVLLITFVRLG
>NC_022524.1|WP_009792833.1|4233483_4233714_+|hypothetical-protein
MKWDQIREKGKTRFVLKFSLGISIPFLIDYYIIKFLLQSFEMELILAEGLFTWIICLLTGGVLGNYAWGKLERHRE
>NC_022524.1|WP_022544444.1|4234011_4234863_-|ROK-family-protein
MLGAIEAGGTKFVCAVGDKTGRIADSIQIPTTVPEETMAAAISFFKQYDIEAIGIGSFGPIDINHDSPTYGYITSTPKTAWTNYPFVETISQAFGVPVGFNTDVNAAALGEARLGAAKGLDSCLYITVGTGIGAGAVVNGQLLQGLSHPEMGHILLRRHPADSYQGKCPYHRDCLEGLAAGPAIEERWGAKGKDLVNSKEVWDLEGYYLAQALMQYILILSPKKIILGGGVMNQSQVFDSIYKYLPELMKDYVALPELADYIVKPGLGDQAGITGALLLAAER
>NC_022524.1|WP_009792831.1|4234876_4235590_-|GntR-family-transcriptional-regulator
MTKYETISSEIRQRIINVSYSPDEPIPDEITLAKEFGCSRMTMKRALDILVLEGLLYRKRGHGTFIVKSAIQNSRVNVVSNESIGLTGLLQGKEVTSKVIKFEVQFPDDEVAAHLAIDKKTPVYHIIRLRLVADEPYVLEKTYMPAALIRGIDDDVLQGSIYEHIRIKLGLTIAGSHRKIRASKSGELDHLHLVCKDDDPILEVEQVAFLDNGVPFEYSFARHRYDKFEVTSANFKR
>NC_022524.1|WP_009792830.1|4235691_4237101_-|glycoside-hydrolase-family-1-protein
MSNHSENEIQYPFPEGFWWGSSASATQTEGAADVDGKGKNIWDHWYETEPNRFFNGVGPEKTSQFYYKYKEDIRLMKEIGHNSFRLSISWSRLIPEGKGEVNDKAVEFYNHVINELIDNDIEPFVNLFHFDMPMELQKIGGWANREVVDAYEEYAKVCFELFGDRVKKWFTHNEPIVPVEGGYLYDFHYPNEINFGKAVQVGYHTILSSAKAIKAYKEQKQDGKIGIILNLTPSYPRSQNPADLKASVLADAFFNRSFLDPSVKGEFPEELVQLLREEGFLPTVEEGDLELIKNNTVDILGVNYYQPRRVKAKENLPNPEAPFMPERFFDNYVMPGRKMNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEEKFRDENGIIQDDYRIDFIKGHLEWVHKAIQEGSNVRGYHLWTFMDNWSWSNAYKNRYGFVSVNLDKDGERTIKQSGKWFKAVSEKNGF
>NC_022524.1|WP_009792829.1|4237379_4239320_-|PTS-transporter-subunit-EIIA
MAKILAVTACPVGIAHTYMAAENLQKAGEVLGVEMKVETQGSIGVENALTEQDIAEADGIIIAADKEVPKDRFAGKRVIVTGVQDGIRKPEELIKRIQIGDAPIYKPELAKNEGAAKKQKENPIYKHLMSGVSYMVPFIVVGGLLIALALTLGGEQTLGGIVIPEDSIWKQVESLGATAFMFMVPILAGFIAVSIADRPGLVPGMIGGYIAANGSFYGSEAGAGFIGGIIAGFLAGYVALAIKKLKVPKAVQPVMPIIFIPILSSVIVGLLFIYVIGAPVAQVFESLTDLLSSMQGGSSIVLALILGAMIAVDMGGPFNKVAFLFGSAMIAEGNYEIMGPIAVAICIPPIGLGLATFVNKRKFTQTEREAGKASFTMGLFGITEGAIPFAAQDPLRVIPSIVTGSMVGSVIAMISQVGDRVAHGGPIVAVLGAVDNVLMFFVAAIAGAVVTALMVTALKKNVEGAPVPALAGAEGSAVPEESVQAAVEKQENAEIRKLTDITSVELIDISLEGEARDDVIDELIERFDAAGVLSSKEAYKQAILNREAQSSTGLGMNIAIPHGKSNAVKRPAVAFGIKREGVDWSSLDGTDAKLIFMIAVPEQAAGDAHLKILQMLSRKLMDDEFREQLLKAESKEQAYQLLEEIQ
>NC_022524.1|WP_022544445.1|4239470_4241393_-|transcription-antiterminator
MTNRQKELLRILLLHEEGALQIKDLSGQLGCVEKTVRNDLDRIEDYLGQYEGTNLIRKPGVGIFIEIDEAARSEILQSLFSDDSKTMEERLFEMAFQLLTSGNAITLKYWAERYFVPNASLKKDLEVIAQWLERFDLLLVSRQRLGHLIEGTELNKRNALAHLSGLIPSGGIGKNPVLDLFQPYEIDIVRKALKEIQNNESIRFTDEALDSLVVHALIMIKRTRQRAPVFVEPAEMEKIALRKEYEYASAFFTRLADSFQLSFPEAEIVYYTWHFISAKRSEEAESALIQDEKAEHVVQLLIERMEKLTLFPFGNDHILASGLAVHMHSVISRIHYGFPITNPLLANIKRMYPYMFSMVILALDDIREGFHISIPEDEAAYIVLHFQASIERLEGKRNIEKKRAIIVCHMGIGMSHLLEAKIEQQYAAIEIAACIGKAEVAEALEKHHPDFIISTVPLEKAGTGYIQISPLFGQEDKERLSQFVDNLRTGKTEGREESFADLMEEDLIFLHVKKEHRYEVVEMLAMALYQKGYAAKEFIHSTVNRERNSATAIGGGISIPHGDPSMISRTAIAAAILDQPLEWGSEKVSLVFLLAVAKENQRDIRRIIGKIASLSESPAAVHELVSAGNAAEFLKMLKQQ
>NC_022524.1|WP_009792827.1|4241645_4242593_-|mannose-6-phosphate-isomerase,-class-I
MKEPLFLEPVFQERIWGGTALRDVFDYSIPSDHTGECWAISGHPNGQSTVKNGEYAGRTIGELWENNRELFGNYSSPVFPLLTKILDANADLSVQVHPNDSYAKEHENGELGKTECWYIIDCDEDAELIFGHTAQTKEEFVERVEKGEWNELLRRVSVKPGDFFYVPSGTIHALCKGTLILETQQSSDTTYRVYDYDRKDAEGNTRELHIDKSIAVTAIPHQSTRVEPSVKKQGEAEVTKFVEAEYFTVYKWNINGKASFAQDKPFLLGSVLNGSGVLKADGKEYAFTRGDHFILPSDFGEYEVEGQAELIVSHV
>NC_022524.1|WP_022544446.1|4242861_4243353_-|hypothetical-protein
MKTLRVIAIILLALFLTACSEPETKDDGEFMFGNLYADSMESGESYYMVLPIEWTGDEPAIIASIELVKEDGAPVTVDEDGIAYVFYGADPLKEMGLYSGDRNIGKIKDITGFKVQGESRVVAKILLDEMKEDESRAAKVTYMIDGEEYEEVVKWDTFEELST
>NC_022524.1|WP_009792825.1|4243770_4245081_+|hypothetical-protein
MSFLKNVFNVLTDKRDIKEPEIYKHFNEKSVTISRLTELAESNDPNIDLKKVENHLKLFTIGQTGEKNVLFELQHSMLPLVILHDVYLEYGDYAAQLDFIVITHKFIMVLEVKKMFGNIHITDKGEFQRVITKNNRIINKEGMYSPINQVERHMGILEKLLKDDGAIKNCPVTYAVTFANSKTILDIAKNAPANIQSKVIRHDQIKTFIQNELEKKSPVFMTDQLVYGIADTILKYSKEKQFNKEDYLLQTSLATQKEISNAASVPAVNQNDKDSILKKSLTEYRLNRSRELNIKPYYIYTNKMLDELLEKKPMTIEHLLEIEGFSQKKAEDYGKDLLAIISGQSPESRFPKKQHTKHIRNNPPNEKEIRSALTAFRTSHSKKLNVKPYYIFTNNTLEAILIKRPGTMSDLLSIEGIGPKKAGEFGQELLDIIKGN
>NC_022524.1|WP_009792824.1|4245254_4246139_+|GAF-domain-containing-protein
MNSNAFSYSKFMNFDEAADSILRMMSRILNINTLFIAKNDQRTNEIVKVVNHGDTLLREGDTLPFEETFCKLSVDHGEKVLFIPDITKSDLSNALNVTRNLGSGSFVGLPIFYEDGRNYGTICGLDTETFELTEEHVELFETMSSLLSYVLELDDANRQIQTLSAPLVPITTGVAILPIIGNINEFRLETIIELALTKSESLSLEYLIIDLSGILQINDMVSSSLLKVANMLSLIGVTPILTGIRPDLALNAISTNIDLKSVKTEASLESALKTIGFTLSRDEGAGSSSRSLFR

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Crispr_ID: NC_022524_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_9

4498094-4498251

Orphan

Consensus_repeat	Method
GCAGTGGTATAGGTGACAGGCACC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_022524_9

>merge|NC_022524|9|4498094-4498251|CRISPRCasFinder
GCAGTGGTATAGGTGACAGGCACCTTTCAAAAAAGAAGTGGTATAGGTGACAGGCACCTTTCAAAAAAGAAGTGGTATAGGTGACAGGCACCCAATTCAATACAAACCTACCCAAATCAAGGTCTTCGCACAGAAAGGTGGTACAGGTGCCTGTCACC

>NC_022524|9|8|4498094-4498251|CRISPRCasFinder
GCAGTGGTATAGGTGACAGGCACC	TTTCAAAAAAGAAGTGGTATAGGTGACAGGCACCTTTCAAAAAA
GAAGTGGTATAGGTGACAGGCACC	CAATTCAATACAAACCTACCCAAATCAAGGTCTTCGCACAGA
AAGGTGGTACAGGTGCCTGTCACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_009792603.1\|4499684_4499897_-\|50S-ribosomal-protein-L31	unknown	unknown	gnl\|CDD\|376487
NC_022524.1\|WP_035401974.1\|4490305_4490743_-\|low-molecular-weight-protein-arginine-phosphatase	unknown	unknown	gnl\|CDD\|319972
NC_022524.1\|WP_022544503.1\|4491488_4492046_-\|manganese-efflux-pump	unknown	unknown	gnl\|CDD\|308338
NC_022524.1\|WP_009792602.1\|4500053_4501328_-\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|236490
NC_022524.1\|WP_009792604.1\|4498900_4499521_-\|thymidine-kinase	unknown	unknown	gnl\|CDD\|235272
NC_022524.1\|WP_009792617.1\|4488245_4488878_-\|CoA-pyrophosphatase	unknown	unknown	gnl\|CDD\|239518
NC_022524.1\|WP_035401979.1\|4488996_4490292_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NC_022524.1\|WP_009792598.1\|4502759_4504046_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|183779
NC_022524.1\|WP_009792596.1\|4505123_4505981_-\|fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|181501
NC_022524.1\|WP_009792595.1\|4506281_4506656_-\|response-regulator	unknown	unknown	gnl\|CDD\|381105
NC_022524.1\|WP_009792612.1\|4492266_4493307_-\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|223088
NC_022524.1\|WP_009792609.1\|4494654_4495353_-\|stage-II-sporulation-protein-R	unknown	unknown	gnl\|CDD\|131884
NC_022524.1\|WP_035402034.1\|4495968_4496832_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl\|CDD\|236467
NC_022524.1\|WP_022544506.1\|4507098_4507629_+\|DUF2529-domain-containing-protein	unknown	unknown	gnl\|CDD\|378487
NC_022524.1\|WP_009792611.1\|4493483_4493924_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224167
NC_022524.1\|WP_022544504.1\|4494081_4494468_-\|general-stress-protein	unknown	unknown	gnl\|CDD\|226252
NC_022524.1\|WP_009792597.1\|4504365_4505013_-\|fructose-6-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234947
NC_022524.1\|WP_009792606.1\|4496839_4497913_-\|peptide-chain-release-factor-1	unknown	unknown	gnl\|CDD\|234801
NC_022524.1\|WP_141195050.1\|4498299_4498761_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009792599.1\|4501759_4502722_-\|class-II-fructose-bisphosphatase	unknown	unknown	gnl\|CDD\|236536

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_009792596.1\|4505123_4505981_-\|fructose-bisphosphate-aldolase	gnl\|CDD\|181501	PRK08610, PRK08610, fructose-bisphosphate aldolase; Reviewed.	0
NC_022524.1\|WP_035401974.1\|4490305_4490743_-\|low-molecular-weight-protein-arginine-phosphatase	gnl\|CDD\|319972	cd16344, LMWPAP, low molecular weight protein arginine phosphatase. Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.	1.35085e-78
NC_022524.1\|WP_022544503.1\|4491488_4492046_-\|manganese-efflux-pump	gnl\|CDD\|308338	pfam02659, Mntp, Putative manganese efflux pump. MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organisms from bacteria to humans, and acts as an important element in the defense against oxidative stress and as an enzyme cofactor.	1.43359e-39
NC_022524.1\|WP_009792602.1\|4500053_4501328_-\|transcription-termination-factor-Rho	gnl\|CDD\|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	0
NC_022524.1\|WP_009792604.1\|4498900_4499521_-\|thymidine-kinase	gnl\|CDD\|235272	PRK04296, PRK04296, thymidine kinase; Provisional.	3.60399e-105
NC_022524.1\|WP_009792617.1\|4488245_4488878_-\|CoA-pyrophosphatase	gnl\|CDD\|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	2.4468e-54
NC_022524.1\|WP_035401979.1\|4488996_4490292_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	2.16265e-47
NC_022524.1\|WP_009792598.1\|4502759_4504046_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|183779	PRK12830, PRK12830, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed.	0
NC_022524.1\|WP_009792595.1\|4506281_4506656_-\|response-regulator	gnl\|CDD\|381105	cd17553, REC_Spo0F-like, phosphoacceptor receiver (REC) domain of Spo0F and similar domains. Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	7.17705e-70
NC_022524.1\|WP_009792612.1\|4492266_4493307_-\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|223088	COG0009, SUA5, Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis].	4.51508e-95
NC_022524.1\|WP_009792609.1\|4494654_4495353_-\|stage-II-sporulation-protein-R	gnl\|CDD\|131884	TIGR02837, Stage_II_sporulation_protein_R, stage II sporulation protein R. A comparative genome analysis of all sequenced genomes of shows a number of proteins conserved strictly among the endospore-forming subset of the Firmicutes. This protein, a member of this panel, is designated stage II sporulation protein R. [Cellular processes, Sporulation and germination].	7.12681e-74
NC_022524.1\|WP_035402034.1\|4495968_4496832_-\|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl\|CDD\|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	2.68743e-106
NC_022524.1\|WP_022544506.1\|4507098_4507629_+\|DUF2529-domain-containing-protein	gnl\|CDD\|378487	pfam10740, DUF2529, Domain of unknown function (DUF2529). This domain is conserved in the Bacillales. The function is not known, but given this domains relationship to the SIS domain it may carry out a sugar isomerase reaction. Several members are annotated as being YWJG, a protein expressed downstream of pyrG, a gene encoding for cytidine triphosphate synthetase.	4.37583e-81
NC_022524.1\|WP_009792611.1\|4493483_4493924_-\|hypothetical-protein	gnl\|CDD\|224167	COG1246, ArgA, N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism].	6.52998e-09
NC_022524.1\|WP_022544504.1\|4494081_4494468_-\|general-stress-protein	gnl\|CDD\|226252	COG3729, GsiB, General stress protein [General function prediction only].	7.92563e-07
NC_022524.1\|WP_009792597.1\|4504365_4505013_-\|fructose-6-phosphate-aldolase	gnl\|CDD\|234947	PRK01362, PRK01362, fructose-6-phosphate aldolase.	6.35087e-149
NC_022524.1\|WP_009792606.1\|4496839_4497913_-\|peptide-chain-release-factor-1	gnl\|CDD\|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0
NC_022524.1\|WP_009792603.1\|4499684_4499897_-\|50S-ribosomal-protein-L31	gnl\|CDD\|376487	pfam01197, Ribosomal_L31, Ribosomal protein L31.	9.37289e-39
NC_022524.1\|WP_009792599.1\|4501759_4502722_-\|class-II-fructose-bisphosphatase	gnl\|CDD\|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	0

>NC_022524.1|WP_009792606.1|4496839_4497913_-|peptide-chain-release-factor-1
MYDRLQAVEDRYERLNELLSDPEIVNDTKKLREYSKEQSGIQETVEAYREYKEVRGQYQDAKAMLEEKLDAEMREMVKEEIGELEDRVEALEARLKILLIPKDPNDDKNVIMEIRGAAGGDEAALFAGDLYRMYSRFAEVQGWKTDVIEASSTGVGGYKEIIFIINGNGAFSKLKFENGAHRVQRVPETESGGRIHTSTATVAVLPEAEEVEIEIHDKDIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGTVVSCQDEKSQIKNKEKAMKVLRARVYDKFQQEAQAEYDQQRKSAVGTGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILQGKLDEVIDALIMEEQSAKLKEASDA
>NC_022524.1|WP_035402034.1|4495968_4496832_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MKVYEALKWASSFLETAGRDSNAGEILLGHFLNMSRSRLLAEMREELDTRMQGAFKEAVQLHADGRPVQYIIGKEEFYGRTFLVNENVLIPRPETEELVLEALKRKEKLFGREAASAAADIGTGSGAIAVTLKLESPDLQVTATDVYGPSLDTAKENADKNGAEIEFILGDLLQPFIEESRKFDIIISNPPYIPLSDMEGMSEVVTENEPHRALFAGQDGLDLYRRFMEELPLVLKEKSLVGFEVGAGQSKAVSELLRTAFPDANIDIVYDINGKDRMVFAEIGWQD
>NC_022524.1|WP_009792609.1|4494654_4495353_-|stage-II-sporulation-protein-R
MTAKSLAKLYIIILSLGTMLSLYIPKTEVAAEDPLVIPQEAIRLRILANSDSEGDQALKRLVRDAVNKEITEWVSELTSIEEARSLIKSRLPEIQEIAENVVEEENFDQTVKANFGKVDFPTKLYGQFLYPAGEYEAILITLGEGDGANWWCVLFPPLCFLDFSNGVAVSDGFEEENQEKGEVGKKELDGNVLEDSKSKEPSSEKEPVFVKEEEEKPEVKFFIKELWDKIFG
>NC_022524.1|WP_022544504.1|4494081_4494468_-|general-stress-protein
MANNNNNDKMSREERGRKGGEATSNNHDKEFYQEIGKKGGEATSENHDKEFYQEIGQKGGEATAESHDKEFYQEIGKKGGEATSENHDKEFYQEIGQKGGEATSENHDKDFYREIGEKGGNSRNNNND
>NC_022524.1|WP_009792611.1|4493483_4493924_-|hypothetical-protein
METMIRCAQNGDENKLAAFLEKANLGTEGISDSINYFLLMEDEEENIKATLGIEPLGSVGLLRSLVLSERASEKDLLLLVEQILRLARERELESLYMATNKKGAAEFFKLLGFQDEKSELPEELYSSAHVQHILTVDNFSFLKLSL
>NC_022524.1|WP_009792612.1|4492266_4493307_-|threonylcarbamoyl-AMP-synthase
MKTEIWSVDKNVDSLNDYPQIKQAAALLAQNETVAFPTETVYGLGGNARNDEAVKKIFEAKGRPSDNPLIIHIADREQLEGIVESVPASADKLMEAFWPGPLTIIFNKKDGQLSETATAGLNTVGIRMPDHPVALAILRESGVPVAAPSANRSGRPSPTTAGHVKEDLNGRIAGIVDGGPTGVGVESTVLDCTGEIPVILRPGGVTKEQLERVVGEVAADPALADEKEAPRSPGMKYRHYAPDAPLYIVEGTRERIQELVNEQHTEGLKAGVLTTAENEKFYDSDFTFICGKRANLETVAASLYEALRSFNSSGVDVIFSESFPAEGVGEAIMNRLLKAAGHRIIK
>NC_022524.1|WP_022544503.1|4491488_4492046_-|manganese-efflux-pump
MTSFFGELITLMLMAFALGMDAFSVGLGMGMFELRLRQIFKIGITIGLFHVFMPLLGMIAGRFLSEQFGSIAAYIGGGLLLLLGAQMIWSSIKDDDSSLITPVGFGLLIFALSVSLDSFSVGLSLGIYGAKTALVLVCFGAAAAILTWAGLLAGRKVQGWLGSYSEALGGAILLAFGIKLLWPFF
>NC_022524.1|WP_035401974.1|4490305_4490743_-|low-molecular-weight-protein-arginine-phosphatase
MRRVLFVCTGNTCRSPMAEAILKSRELPGIEVKSAGVFAANGGQASAHAKQVLEEQGIAHVHTSSALTAELVEWADVILTMTSGHKWNVVSMFEGAEGKTFTLTEFAGEHGGEILDPFGGSLEIYRETFNELKKHIEQIINKLEK
>NC_022524.1|WP_035401979.1|4488996_4490292_-|methyl-accepting-chemotaxis-protein
MMEKKRYKFGLRKKLVLLTTILAFITYTTSAVFIYGLYPIVKEYLPFGEAAFNIITLSLGAMWSGVLTFVAAGFITKPLQKLEKTALKAAEGDIREDAELSKSDDEIRSLGAAFNHMLSNLREMVAKIDENFQHTNDKVISISQEASAAAEQAASISRTIGEISLGADSSAVSIQATAESVEDATRIAEEVQQQAKTSQQVSGELVDDLNESKKVIHSLVTGITKLAEDNQESLQTVKRLEDNAAKVEQIIQLVGDIAAQTNLLALNASIEAARAGEHGKGFAVVAEEVRKLADESAKAVQGISELIKNIQNEVQNVVRQITDQVETASAEGKKGVKTNQVIGEMTNTVNQMASSVTTISSLVEQQMEGIRHSATQSQEVAAIAEETSAGAQEVASATENQSMVISNVEKLAFELKDEAEKLKETITKFRV
>NC_022524.1|WP_009792617.1|4488245_4488878_-|CoA-pyrophosphatase
MNIEEIIAGLGSRTPAILGSNKFINYSVLVPLIEKEDGVHVLFEVRSMEMRRQPGEICFPGGRVDRSDPDVKHTAIRETTEELGIPMDEIRGTVPLDYMVSPFGMIIYPFAGMLKPSRPFQVNPKEVGEVFTVPLSYLLKAKPEIYKMNFRLEPENGFPFDRIAGGENYNWQTRSMEECFYYFEDKVIWGLTARILQHFIEIVNELPEQK
>NC_022524.1|WP_141195050.1|4498299_4498761_-|hypothetical-protein
MMKSIFAAAAVLLAALLGGCAQDDNVAGIHEQNEDQNGTNLITDGGGQVKRGLDQVSDDDRDRTMSDQNPNFLNIDGGRVNDQSDVDKARQVVNQYTEYEPDEVWINGGRMWVTAHTDKSLSAEEKRKAQAELHKTLTKALPRYNIEVRLSER
>NC_022524.1|WP_009792604.1|4498900_4499521_-|thymidine-kinase
MYVMKHHGWVEVICGSMFSGKSEELIRRVRRAQFAKQKIAVFKPQIDNRYSEEAVVSHNGTSVIAKPISHSTDIFKHIDEDMEIIAIDEVQFFDAEVVKVIQHLADSGYRVIAAGLDQDFRGEPFGQMPALMAIAELVTKLQAVCAVCGSPASRTQRLINGKPASYDDPVILVGASEAYEPRCRHHHEVPKSPNVLNSSETTRTLS
>NC_022524.1|WP_009792603.1|4499684_4499897_-|50S-ribosomal-protein-L31
MKAGIHPNYKKITVTCACGNQFETGSVKDEVRVETCSECHPFYTGRQKFAEAGGRVDRFNKKYGLKGQQQ
>NC_022524.1|WP_009792602.1|4500053_4501328_-|transcription-termination-factor-Rho
MGLNISSLENMKLKELYELAREYKVSYYSKLTKKELIFAILKARAEQEGYFFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGKVRPPKENERYFGLLQVEAVNGDDPESAKERVHFPALTPLYPDRQMKLETTPKHVSTRIMDVLAPVGFGQRGLIVAPPKAGKTMLIKEIANSITTNHPEAELIVLLIDERPEEVTDIERSVAGDVVSSTFDEVPENHIKVAELVLDRAMRLVEHKRDVIILMDSITRLARAYNLVIPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEFKGTGNMELHLDRQLAERRIFPAIDIRRSGTRKEELLIPKEHLDKLWAIRKSMSDAPDFAEKFLRKLKQTKSNEEFFANLGEEMKNGRRSQS
>NC_022524.1|WP_009792599.1|4501759_4502722_-|class-II-fructose-bisphosphatase
MERSLSMELIRVTEAAALASARWMGRGVKDEADDAATSAMRDVFDTVPMKGTVVIGEGEMDEAPMLYIGEKLGTGYGPRVDVAVDPLEGTNIVASGGWNALAVLAVADHGNLLHAPDMYMDKIAVGPEAVGEIDINASVIDNLRAVARAKNKDIEDVVATVLNRERHQHIISQLREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLAAVALKCLGGEIQGKLVPHSDAEVERCQSMGLDLGKILRMEDLVKGDDAIFAATGVTDGELLRGVQFKGSYGSTHSLVMRAKSGTVRFIDGRHSLKKKPHLVMK
>NC_022524.1|WP_009792598.1|4502759_4504046_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MEKLMIAGGYPLKGTVRISGAKNSAVALIPATILADSPVTIEGLPDISDVQILKGLLEEIGGSVDFADNDMTVDPSSMISMPLPNGKVKKLRASYYLMGAMLGRFKKAVIGLPGGCHLGPRPIDQHIKGFEALGASVTNEQGAIYLRADELKGARIYLDVVSVGATINIMLAAVRAKGKTIIENAAKEPEIIDVATLLTNMGAKIKGAGTDVIRIEGVDQLHGCRHTIIPDRIEAGTYLILGAAAGEGILIDNVIPQHLESLIAKLREMGVNIEAGDDQIFVSPAEKMKAVDIKTLVYPGFPTDLQQPFTSLLTGAEGTSMVTDTIYGARFKHIDELRRMNASIKVEGRSAIINGPIRLQGAKVKASDLRAGAALVIAGLKAEGITEVTGLEHIDRGYSHLVEKLNGLGATIWRENLTKEEMEQMKNA
>NC_022524.1|WP_009792597.1|4504365_4505013_-|fructose-6-phosphate-aldolase
MKFFIDTANLEEIKEAHALGILAGVTTNPSLVAKEKNISFHDRLKEIAELVPGSVSAEVIALDAEGMIKEGKELAAIAPNITIKVPMTPDGLKAVHAFSKEGIKTNVTLIFSANQALLAARAGASYVSPFLGRLDDIGHNGLDLVTSIREIFDIHGIETEIIAASVRHPQHVTDSALRGAHIATVPLKVINQMFNHPLTDKGIEAFLADWDKRSE
>NC_022524.1|WP_009792596.1|4505123_4505981_-|fructose-bisphosphate-aldolase
MPLVSMTDMLNKAKSEGYAVGQFNLNNLEFTQAILQAAEEEKSPVILGVSEGAARYMGGFKTTVKMVEGLLEDYKITVPVAIHLDHGSSFDKCKEAIDAGFTSVMIDASHGPFEENVEITSKVVEYAHSKGVSVEAELGTVGGQEDDVVADGVIYADAKECDELVKRTGIDCLAPALGSVHGPYKGEPNLGFVEMEEIGKLTGMPLVLHGGTGIPTKDIQKAVSLGTAKINVNTENQIASAKRVREVLAADTEVYDPRKYLGPAREAIKETVIGKMREFGSSNKA
>NC_022524.1|WP_009792595.1|4506281_4506656_-|response-regulator
MKGKILIVDDQFGIRILLNEVLQKEGYDTYQAANGVQALEIVTKHSPDLVLLDMKIPGMDGIEILKRMKVIDQDIRVIIMTAYGELDMIQEAKDLGALTHFAKPFDIDDIRAAVKKYVPITNSF
>NC_022524.1|WP_022544506.1|4507098_4507629_+|DUF2529-domain-containing-protein
MLKMFSTQLTGIFKKLMEKEEFSIEDAARLLAQAPAGEGRIQIYATREMKAAALEATEGAEPLASAAHWTDAHSENDIADTDRFLIISRHSNDGQAVALAKALSEKMIPFTAISTAVEGEGPSLAELADVHIDLKLTKGLLPDEEGNRFGYPSAIAALFVYHGLKFTIDEILSEYE

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Crispr_ID: NC_022524_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_10

4577430-4577533

Orphan

Consensus_repeat	Method
AGTGGTATAGGTGCCTGTCACCGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022524_10

>merge|NC_022524|10|4577430-4577533|CRISPRCasFinder
AGTGGTATAGGTGCCTGTCACCGTTATAAACCAAAAACCCCCGTCCCGGATGGGATTGGGGGCTGCAGCTGGTGTCTAGTAGTGGTATAGGTGCCTGTCACCTA

>NC_022524|10|9|4577430-4577533|CRISPRCasFinder
AGTGGTATAGGTGCCTGTCACCGT	TATAAACCAAAAACCCCCGTCCCGGATGGGATTGGGGGCTGCAGCTGGTGTCTAGT
AGTGGTATAGGTGCCTGTCACCTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_009794373.1\|4571195_4572512_+\|YjiH-family-protein	unknown	unknown	gnl\|CDD\|225851
NC_022524.1\|WP_022544528.1\|4573105_4574218_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235878
NC_022524.1\|WP_009794380.1\|4579396_4579858_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009794381.1\|4580039_4580762_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_022524.1\|WP_009794376.1\|4574386_4574863_-\|Cys-tRNA(Pro)-deacylase	unknown	unknown	gnl\|CDD\|237976
NC_022524.1\|WP_035402912.1\|4585309_4586962_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|226650
NC_022524.1\|WP_009794368.1\|4565926_4566826_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|187613
NC_022524.1\|WP_050767308.1\|4572569_4573055_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240291
NC_022524.1\|WP_009794385.1\|4583059_4583668_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_009794390.1\|4587773_4589006_+\|peptidase-T	unknown	unknown	gnl\|CDD\|235484
NC_022524.1\|WP_009794388.1\|4587007_4587391_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|366361
NC_022524.1\|WP_009794370.1\|4568467_4569235_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NC_022524.1\|WP_009794377.1\|4574998_4576315_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223936
NC_022524.1\|WP_009794378.1\|4576311_4577199_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|224131
NC_022524.1\|WP_022544533.1\|4589197_4590718_+\|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	unknown	unknown	gnl\|CDD\|234660
NC_022524.1\|WP_009794371.1\|4569221_4570988_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_022524.1\|WP_009794369.1\|4566976_4568296_+\|short-chain-fatty-acid-transporter	unknown	unknown	gnl\|CDD\|224942
NC_022524.1\|WP_009794382.1\|4581295_4582201_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223566
NC_022524.1\|WP_022544530.1\|4582438_4582975_+\|thiol-disulfide-oxidoreductase-ResA	unknown	unknown	gnl\|CDD\|179545
NC_022524.1\|WP_087944255.1\|4583682_4584861_-\|ParM/StbA-family-protein	unknown	unknown	gnl\|CDD\|212669

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_009794373.1\|4571195_4572512_+\|YjiH-family-protein	gnl\|CDD\|225851	COG3314, COG3314, Uncharacterized protein conserved in bacteria [Function unknown].	1.40497e-112
NC_022524.1\|WP_022544528.1\|4573105_4574218_-\|hypothetical-protein	gnl\|CDD\|235878	PRK06851, PRK06851, hypothetical protein; Provisional.	0
NC_022524.1\|WP_009794381.1\|4580039_4580762_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.48373e-32
NC_022524.1\|WP_009794376.1\|4574386_4574863_-\|Cys-tRNA(Pro)-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	7.36514e-77
NC_022524.1\|WP_035402912.1\|4585309_4586962_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|226650	COG4187, RocB, Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism].	5.36719e-172
NC_022524.1\|WP_009794368.1\|4565926_4566826_-\|glucose-1-dehydrogenase	gnl\|CDD\|187613	cd05355, SDR_c1, classical (c) SDR, subgroup 1. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.7563e-159
NC_022524.1\|WP_050767308.1\|4572569_4573055_-\|hypothetical-protein	gnl\|CDD\|240291	PTZ00146, PTZ00146, fibrillarin; Provisional.	0.00185954
NC_022524.1\|WP_009794390.1\|4587773_4589006_+\|peptidase-T	gnl\|CDD\|235484	PRK05469, PRK05469, tripeptide aminopeptidase PepT.	0
NC_022524.1\|WP_009794388.1\|4587007_4587391_+\|VOC-family-protein	gnl\|CDD\|366361	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	2.2073e-20
NC_022524.1\|WP_009794370.1\|4568467_4569235_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	6.15214e-45
NC_022524.1\|WP_009794377.1\|4574998_4576315_-\|UDP-glucose/GDP-mannose-dehydrogenase-family-protein	gnl\|CDD\|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	5.41994e-180
NC_022524.1\|WP_009794378.1\|4576311_4577199_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	1.43937e-153
NC_022524.1\|WP_022544533.1\|4589197_4590718_+\|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	gnl\|CDD\|234660	PRK00139, murE, UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional.	5.0132e-135
NC_022524.1\|WP_009794371.1\|4569221_4570988_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.57799e-175
NC_022524.1\|WP_009794369.1\|4566976_4568296_+\|short-chain-fatty-acid-transporter	gnl\|CDD\|224942	COG2031, AtoE, Short chain fatty acids transporter [Lipid metabolism].	0
NC_022524.1\|WP_009794382.1\|4581295_4582201_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	1.84869e-57
NC_022524.1\|WP_022544530.1\|4582438_4582975_+\|thiol-disulfide-oxidoreductase-ResA	gnl\|CDD\|179545	PRK03147, PRK03147, thiol-disulfide oxidoreductase ResA.	1.50534e-61
NC_022524.1\|WP_087944255.1\|4583682_4584861_-\|ParM/StbA-family-protein	gnl\|CDD\|212669	cd10227, ParM_like, Plasmid segregation protein ParM and similar proteins. ParM is a plasmid-encoded bacterial homolog of actin, which polymerizes into filaments similar to F-actin, and plays a vital role in plasmid segregation. ParM filaments segregate plasmids paired at midcell into the individual daughter cells. This subfamily also contains Thermoplasma acidophilum Ta0583, an active ATPase at physiological temperatures, which has a propensity to form filaments.	2.84285e-41

>NC_022524.1|WP_009794378.1|4576311_4577199_-|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MYVRKAIIPAAGLGTRFLPATKAQPKEMLPIAGKPAIQYIVEEAAASGIEDIIIISGRGKRAIEDHFDKSYELEETLAKQNRHELLEAVEAVSNLASIHYVRQKEPKGLGDAIYCARSYIGDEPFAVMLGDDVVQGERPCLSELLQAHQQYGGTVVGVQEVAAEELCKYGVVEPEKFIDRQLMKLKSLVEKPPKGLEPSSYALMGRYILPPEIFSILETLPAGANKEVQLTDAIRFLAGITPVYGVVLSGSRYDIGDRMGFLKANIEMAMLQADIRTDLIVYLEKMLMNRQGAAL
>NC_022524.1|WP_009794377.1|4574998_4576315_-|UDP-glucose/GDP-mannose-dehydrogenase-family-protein
MNITIAGTGYVGLVTGVCLAEKGHMVICYDHDEEKTAALSAGVPLIYEPGLEAMLDRNMKEGKLAFTSDPEIAYRNPECIFLAVGTPEKEDGSADLSFIYSACGMIADKLGHETVIAIKSTVPAGTNEKLRAFFKQNLSIPVHMVSNPEFLREGSGIRDTFQADRIIIGSDSLKAARTVEEIYGPFSVPIIHMDAKSAELAKYASNAFLAAKISFINEMAHLCERLGANIDDVAAGMGLDKRIGSRFLQAGAGFGGSCFPKDTKALGMMAEEHQYEFRILKALMEVNAIQKKVLLHKAKSIMPLAGKNAAVLGLAFKPNTDDIREAPSIELIRDLVDEGASVSVYDPIASSRAMGVLPDSVHFAASIHEAIHGKDLAFITTEWAEICRFPLSAYKEFMRDPLVLDGRNCYTLQEAESANIRYISIGRPECPARSAVFW
>NC_022524.1|WP_009794376.1|4574386_4574863_-|Cys-tRNA(Pro)-deacylase
MAQGKTNAMRLLDAAKLEYNSLSYDSKDGKIDGVSVAGKIGRDPELVYKTLVAQAGRNVYVFIIPVEAELDLKKAAKAAGEKKVEMIPVKDIQKLTGYIRGGCSPVGMKKLYPTFIDSQGEQLESIIVSGGKIGLQIELAPERLKELIEAEWKDLVKE
>NC_022524.1|WP_022544528.1|4573105_4574218_-|hypothetical-protein
MAGKIIDYFAGGNTARGFHSLYESNLQDLSRLFILKGGPGTGKSTLMKGIGSKWLDKGFNIELIHSPSDNDSVSGVIIPALKIGIVDGTAPQVIEPKAPGAIEEYVNLGEAWDSAQLATQKGKILRLNSKIEAFYKQAYSTFAEALKIHDDWEKFYIDSMDFQKANQLTSKLTQVFFGKMTLNKISSVKHRFLGAATPNGAVDCIPNLTLDIHKRYFIKGRPGSGKSTLLKKLAAEAEKRGFDIEVYHCGFDPNSLDMLIIRELGLAIFDSTAPHEYFPSRDGDEIIDMYEQLIAPGTDEIFAEEIKEIAAKYKTKMTEATGCLSDAKRLNDELEKIYSEAMDYTIVDTIRGRIEEKILRVETPHPIYAD
>NC_022524.1|WP_050767308.1|4572569_4573055_-|hypothetical-protein
MYYPLPQADLQQTPERFNVFPGGGGQPGIPFPPGFPGGTPFPGQPGFPGGGGQPGFPGGGGQPGFPGGGEAQGQAGGPPSSPPPSFTPELQTQSASVFAVDPGAIRGCLYRFTYLWLNNGRSFWFYPTFVGRTSVAGWRWRGFRWEYYGTDTSRIRSFRCT
>NC_022524.1|WP_009794373.1|4571195_4572512_+|YjiH-family-protein
MLFLIPSLIGISLFMLPISYKGEVTIPIAILSGLVQDLLTAYLPAIMTVIIFLTFAGTLLAKLVKPAFIRRSAFFTALFDVPAIWFAARVLGAIFALMTFYQIGPEWVWSENTGGLLLYDLLPVLFSVFLFAGLFLPLLLNFGLLELFGSLLTKVMRPLFRLPGRSSVDCAASWLGDGTIGVLLTSKQYEEGFYTKREAAVIGTTFSVVSITFSLVVISQVDLGSYFVPFYLTVLIAGIVAALICSRIPPLSTKPDTYVTEDAPQLDETIPEGYTPLSWGITQATAKAATNRGIKQFFEQGAKNILDMWMGVAPIVMALGTLALIVAEFTPIFKVAGMPFIPLLELMQVPEAKAASETLVVGFADMFLPSVIGSGIESEMTRFIVACTSVTQLIYMSEVGGLLLGSKIPVSLKDLIIIFLERTIITLPVIVLAAHLIF
>NC_022524.1|WP_009794371.1|4569221_4570988_+|ABC-transporter-ATP-binding-protein
MTKNEDPAIKKGSWKAFWGLLKDSKPPRWILLSAIILSILETGAGLIVPLFTKSMVDQLAASSLEMSVVLLLAGAFIIQTVSSGFSYYFLSYIGEAVVASIRRKLWGQILHLPVPFFDQQQSGETMSRVTQDTNIVKNLITQHLISFLTGIISIIGSVIILLLIDWKMTLVMIIAVPLAIAMIMPLGQKMYKISRATQDEMASFSGNLGRVLADIRLVKAYHAEKAEQESGDKGIRHLFQFGMREAKIQAVISPFMTFIMMFVLVILIGYGGVRVASGALSAGSLVAIIIYMFQIVVPFSQMASFFTAFQKAVGATERIQHIFDTEKEVDKGTEAVANPSQDITFEKVSFAYKEKEILGGASLTVPAGKTTAIVGPSGGGKTTLFALLERFYLPQTGRILLGGQDISSFRLHAWRSSIGYVSQESPIMSGTIRDNIAYGMEREVLDKEIERAAELANASEFIDALPDGFDTQVGERGIKLSGGQRQRIAIARALIRNPRILLLDEATSNLDSTSEHLVQKALEHLMEGRTTLVIAHRLSTVVDADQIAVLENGSITGTGTHRELYEKHSLYRELAEQQLSDRSAASGG
>NC_022524.1|WP_009794370.1|4568467_4569235_+|MerR-family-transcriptional-regulator
MAGKYSIGQFSKKTGTTIRTLHYYDEIGLLEPTEITDSGRRYYSDPDFTVLQRIVTLKYLGYSLEQIKGMLQNEKWSLKDSLAFQRAEMIRKKEEVEGVIRALDRALYVMEDQNEVDAGIFISLINTIHREDEQKEWLKSFLPEERVDSIYAIPEEKQREYESRWVSISMGLKELAGSDPASGEVQALIEAMMEIVDEISGNDPSLLKEISSVDLSDEDDGGLFHIPFSPEEEEWLAAALGLYLEQKGMNVDDEK
>NC_022524.1|WP_009794369.1|4566976_4568296_+|short-chain-fatty-acid-transporter
MKAVVSLFNRIMQRYLPDPFLFVVILTFAVFGLGLIFTESSPYQMVQFWGGGFWGLLTFSMQMVLVLVTGHVLASSRIFKKGLGSLAGLAKSPGQAIILVTVISILASLINWGFGLVIGALFAKELAKKVKNVDYRLLIASAYTGFIVWHGGISGSIPLTIATAGHFSEDLIGIIPTDQTIFAFFNIAIILGIFIIMPIVNRMMMPSREDTVAVDPALLEEDQPAAAIEQAALTPADRLENSKILSMLIGIFGLVFLFYYFATNGFKLNLDIVNFLFLFLGILFHGTPKQFLNATVNAVKGASGIIIQFPFYAGIMGMMTTSGLAAVMSEAFVSISNDFTFPFFAFLSAGLVNFFVPSGGGQWAVQAPVMLEAAQTLGVSIPKTAMAVAWGDAWTNLIQPFWALPALAIAGLKAKDIMGYCVLALFVSGIIISLGMLFL
>NC_022524.1|WP_009794368.1|4565926_4566826_-|glucose-1-dehydrogenase
MYPVYPYYGKKEECKEKPLSFPPQHQDVQPGLEYQMVPRPISEDPDYRGSGKLKGKVAIITGGDSGIGRAAAYAFVKEGAKVVIVYLNEHQDARETQERIRELGGESLFIAGDMRREDFSREIVEKTLHHFGRIDILVNNHGVQFVQKSILDITREQLFDTFETNIFAFFYLTKAVLPHMKAGGSIINTTSVTAYEGHKDLIDYSSTKGAIVTFTRSLSLSLEKNGIRVNAIAPGPIWTPLIPASFSAKKVSEFGTDTPMKRAGQPFELAPAYVYLASDDSRYMSGQVLHINGGTMVSS
>NC_022524.1|WP_009794380.1|4579396_4579858_-|hypothetical-protein
MANKRLELIVDELLEKAGSTAVVVLEDYFGGNRFAGGKYSMGTHTITLYIEEIKKQCLQIFSSLDHFEEYFAVVCAHEIGHAEDRELGELADRFDLAATSVERNQLALLIEENAWEFAEKLLGHINIAFVKTIIYHSLQPYMELLEAEAAEAV
>NC_022524.1|WP_009794381.1|4580039_4580762_+|class-I-SAM-dependent-methyltransferase
MKPSYQDALAFFGMGGAHPGGLALTKRVLGMEQLSGKAKVLDAGCGTGQTAAFIAKTFNCQVTAIDRHPLMIGQAKKRFAHEGLAVNALRENIENLSFADNSFDYIIAESVIIFTNIEQSLKEIKRVLKPGGIFLDLEMTAEEPLNPQEKNQIQSVYSIKRLLTEGEWLQTYTSEGFRSPRTVAANSIYTEIINSPWDQQPEIANPHLVNPKYEHILIEHQKLLAIYAERLGYRVYRMQK
>NC_022524.1|WP_009794382.1|4581295_4582201_-|NAD(P)/FAD-dependent-oxidoreductase
MTYDCIIIGGGIAGLQAAIQLGRYKHRVLVVDSNHGRSTICKSYHNILGYPDGVSGQELRDIGRSHAEKLGVEFKLGKAEKAEKKGSGFKITLEDGGQLESERLLLSTGVMDRIPEFPNLYPTLGVSVYVCPDCDGYEIKDKRTIVIGSGNPGANMAVTLSYWTDELVFINHEKKEVSQELMDKLRELNIEYMEESIAEAIADGPNIQGFLLENGKRVMGERGFTAFGGNEVKSDLAKQLGVERLENKHINVDSRSKMTNVKNVWAAGDVVAHSEQVTIAMGDGSQAAIWIHKSILAEENK
>NC_022524.1|WP_022544530.1|4582438_4582975_+|thiol-disulfide-oxidoreductase-ResA
MKAKKTHRLVMRSIILLVLFFAAGYTLYQNFFLKESGTKAMLNEKAPDFALQALDGGKTKLSEYNGKPVLINFFATWCAPCKNEMPAIQSTYEEFKDDGFEVLAVNLSEPEISVKNLKEQLGIDFQILLDKNNAVESMYDVYKIPSSFFIDSSGKIARVYEGEMSEEDLNDWVGELVD
>NC_022524.1|WP_009794385.1|4583059_4583668_-|hypothetical-protein
MTKSSSKGIERGQTIAFRVPSDTPEYLVKQLQKLKEAEKRNFSSRIADYVMQGVSQSVKQEQETVTIPLPKALSKMQRDWLKHEHSEALLGSIIYQLITDPVRSAALLASLNSKSTDIDEALYLQERKEREEKPVYQADVPPPSPPVQEVEDAIPAYTDGADDDLDDIDWSSVQIDRSAEDEDQEEESMEDLLGDFLAHMNK
>NC_022524.1|WP_087944255.1|4583682_4584861_-|ParM/StbA-family-protein
MKNPRIAAVDVGNDSLKALFGKLDYELNIPNVIARDVADRPVIGIEELDSKEPLDGIHVKVHSPALKDNNAIYRVGTLATKSDNASELDPGSSKSEEDQTLVMLFVSLALDAVREENAGLFPKNNNIIDTNYILGTGLPLREVKEGKDAGYRSKLLGSVHQVEFLVTPKYQGIKVNLKFSDVKVYPEGFAAFINLVMDNDLNIINKELIDKRILIQDIGGLSTDIAVIKNRTVDDDKAQGFNLGVSESLEMIREEIRSKHGVELDSRRDVVEIITKKNDRNHIMVKGSRTSVHDITDRILFDLAKKQYRLLRNVWQKNSQTEICYFVGGGSAVLKEYIKSLNNSLDGYNIDFFEDEKESIWMMANAYYKLVADHLKRTSKPDKQDEKKPVKA
>NC_022524.1|WP_035402912.1|4585309_4586962_+|M20/M25/M40-family-metallo-hydrolase
MLNCREKTLAFTKQLVNIESIVNTNGEKVIAHSLYTLLSSFPYFTENCGQLVIEQTIDDELERYNVLAFVKGTKRKSSRTVILMGHMDTVGIDDFNQLRDAACDPDQLADLFRKEELPSGAKEQLESGDWMFGRGVLDMKSGLASHLYLLKYYSDHPEELEGNLVFLAECDEEDGSHGVLSALKTLKKWKDEHKFHYAAAINADFVSPRFEGDTNRYIYKGTVGKLLPSFFITGAETHVGSCFEGLDPNFLAAELTRQISYNPELSNEALGETTVPPVSLKQTDLKPSYTVQTALSAYVYYNFFIHSWSPKEVLEKLRKQAHIAFSNALSSFEQRNRQFAELSGEPYAELPWQPRIYTYEEMHRMLMEEYGQGYIAHMDAFKEELLLDKELDTRMYAARVVEEAWKWMKDKSPAMILFYSSLYSPRIELSGKTEDERRLIDALDQAVEEIQPSYPHPIIAKNFFPYISDMSFIALSDDEAGISAVTDNNPGWGTKHYVEYSDIRELNVPVINIGPYGLDAHKKLERMEMKYSLEIVPNLTNRVIQQVLKG
>NC_022524.1|WP_009794388.1|4587007_4587391_+|VOC-family-protein
MAGKRIDHVGVMVKNIEKSIEFYTNAVGMELKAEVPHSNGVIKLAFLGFTGNEETELELIQGYNDHLPEEGTVHHFAVSTDDVEGEFTRLKELGIELIDQEITTLPNGYKYFFFYGPDREWIEFFQR
>NC_022524.1|WP_009794390.1|4587773_4589006_+|peptidase-T
MKKDLIERLVSYAKMDTQSDDNSTTCPSTPGQLELGRKLVEELKSIGMQDAEMDDNGYVMATLPSNTEKQVPVIGFLAHVDTATDFTGKNVSPQITENYDGGDIVLNDSLHIVLSPKDFPSLEQYKGHTLITTDGTTLLGADNKAGIAEIMTAMEYLIKHPEIKHGAIRVAFTPDEEIGRGPHKFDVKAFNAAYAYTMDGGPLGELQYESFSAAGAKITVNGTNIHPGSAKGKMVNSIKIAMELQNSLPQEQAPELTEGYEGFFHLGSFKGDVEKTEMSYIIRDFDRTEFEHKKELLEKAVASLQEKYGKERIQLELKDQYYNMKEKIEPVIEIVDIAGEAMKKLDIEPQILPIRGGTDGSQLSYMGLPTPNIFTGGENYHGKYEYISVDNMEKAANVIIEIVKLFEEKA
>NC_022524.1|WP_022544533.1|4589197_4590718_+|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase
MDIYFEQYGQLNIRQRWGSPSQKINSISYDSRNAGPQSVFVCMGGENHDGHTFLEEAIAKGAAVLAGENAAILEEFSRKFPELTFLQTEDARAFLAQLSIIFHGRIHEKIHTVGITGTNGKTTVAAFVKSLMTALGIPSGSIGTNGVLSSMGPVSFVQSTPTTPEASDLHAIFADFAKRGDQLAAMEVSSVAIEQQRTAGINFDVAIHTNLSPEHLEFHKTFENYKQAKLKLFRQAKRAVVNLDDEGMGADIIKDFQGSLLTYSLKKDSAADVKASNIRVTNDGTSFELKLGNDSYIVRTPVFGSYNVANLLSAICTAMHLGFTIGQIIEALPRVENPSGRFEVLKEFGRRKIIIDYAHTPVALKSLLKEAKKLPHKRLIVMITGIGIRDKEKMPQMAQAVENQADQVIVSVDHPGFLDPWEVVGHVMKGFSNPRAGNILQEPTRRDGVLAALSVSDEDDLILLTSGCINGAQIVKGEKIPHSDKEIIQEFFRNLEESKALERYEA

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Crispr_ID: NC_022524_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022524_11

4678458-4679274

Orphan

Consensus_repeat	Method
CTCTCTTGAGTGACTCATANCGGTTCT	CRT

15 spacers

The CRISPR arrays of NC_022524_11

>merge|NC_022524|11|4678458-4679274|CRT
TTTTTTGAGATCCCTCATACCGGTTCTTTGAGGTACTCTGGGGCAGGGGGTCTCTCTCTTGAGTGACTCATATCGGTTCTCTGAGGCACTCTGGGGCAGGGGGTCTCTCTCTTGAGTGACTCATATCGGTTCTCTGAGGCACTCTGAGGCGGGGGGTCTCTCTCTTGAGTGACTCATATCGGTTCTCTGAGGCACTCTGGAGTGGGCATTCACTCTCTTGAGTGACTCATATCGGTTCTCTGAGGCACTCTGGGGCAGGGGGTCTCTCTCTTGAGTGACTCATATCGGTTCTCTGAGGCACTCTGGAGTGAGCATTCACTCTCTTGAGTGACTCATACCGGTTCTTTGAGGCACTCTAGGGCAGGGGGTCTCTCTCTTGAGTGACTCATATCGGTTCTATGAGGCACTCTGGAGTGAGCATTCACTCTCTTGAGTGACTCATATCGGTTCTCTGAGGCACTCTGGAGTGAGCATTCACTCTCTTGAGTGATTCATACCGGTTCTTTGAGGCACTCTGGGGCAGGGGGTCTCTCTCTTGAGTGACTCATATCGGTTCTCTGAGGCATTCTGGAGCAGGAATCACTCTCTTGAGTGACTCATACCGGTTCTTTGAGGCACTCTGGTGCGGAAATCTCTCCTTGAGTGACTCATACCGGGTCTTTGAGGCACTCTGGGGCAGGGGGTCTCTCTCTTGAGTGACTCATATCGGTTCTCTGAGGCACTCTGGGGCAGGAATCACTCTCTTGAGTGACTCATACCGGTTCATCGAGGCACTCTGGGGCGGAAATCTCTCTCTTGAGTGACTCATGACAATTCC

>NC_022524|11|2|4678458-4679274|CRT
TTTTTTGAGATCCCTCATACCGGTTCT	TTGAGGTACTCTGGGGCAGGGGGTCT
CTCTCTTGAGTGACTCATATCGGTTCT	CTGAGGCACTCTGGGGCAGGGGGTCT
CTCTCTTGAGTGACTCATATCGGTTCT	CTGAGGCACTCTGAGGCGGGGGGTCT
CTCTCTTGAGTGACTCATATCGGTTCT	CTGAGGCACTCTGGAGTGGGCATTCA
CTCTCTTGAGTGACTCATATCGGTTCT	CTGAGGCACTCTGGGGCAGGGGGTCT
CTCTCTTGAGTGACTCATATCGGTTCT	CTGAGGCACTCTGGAGTGAGCATTCA
CTCTCTTGAGTGACTCATACCGGTTCT	TTGAGGCACTCTAGGGCAGGGGGTCT
CTCTCTTGAGTGACTCATATCGGTTCT	ATGAGGCACTCTGGAGTGAGCATTCA
CTCTCTTGAGTGACTCATATCGGTTCT	CTGAGGCACTCTGGAGTGAGCATTCA
CTCTCTTGAGTGATTCATACCGGTTCT	TTGAGGCACTCTGGGGCAGGGGGTCT
CTCTCTTGAGTGACTCATATCGGTTCT	CTGAGGCATTCTGGAGCAGGAATCA
CTCTCTTGAGTGACTCATACCGGTTCT	TTGAGGCACTCTGGTGCGGAAATC
TCTCCTTGAGTGACTCATACCGGGTCT	TTGAGGCACTCTGGGGCAGGGGGTCT
CTCTCTTGAGTGACTCATATCGGTTCT	CTGAGGCACTCTGGGGCAGGAATCA
CTCTCTTGAGTGACTCATACCGGTTCA	TCGAGGCACTCTGGGGCGGAAATCT
CTCTCTTGAGTGACTCATGACAATTCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022524.1\|WP_022544558.1\|4676290_4676983_+\|LrgB-family-protein	unknown	unknown	gnl\|CDD\|377236
NC_022524.1\|WP_009794499.1\|4683303_4684041_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NC_022524.1\|WP_022544561.1\|4686839_4688225_-\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273919
NC_022524.1\|WP_009794495.1\|4680276_4681923_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_156917034.1\|4673755_4674394_-\|DUF3885-domain-containing-protein	unknown	unknown	gnl\|CDD\|379022
NC_022524.1\|WP_009794503.1\|4685064_4686069_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|238571
NC_022524.1\|WP_009794485.1\|4671822_4672362_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
NC_022524.1\|WP_009794489.1\|4675319_4675757_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_022524.1\|WP_009794498.1\|4682506_4683211_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_022524.1\|WP_009794484.1\|4670676_4671552_-\|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl\|CDD\|369882
NC_022524.1\|WP_009794493.1\|4677770_4678379_+\|DUF1311-domain-containing-protein	unknown	unknown	gnl\|CDD\|377758
NC_022524.1\|WP_009794494.1\|4679497_4680274_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_022524.1\|WP_009794488.1\|4674403_4675207_-\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_035402941.1\|4675916_4676318_+\|CidA/LrgA-family-holin-like-protein	unknown	unknown	gnl\|CDD\|167253
NC_022524.1\|WP_009794492.1\|4677039_4677459_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NC_022524.1\|WP_022544556.1\|4672406_4673597_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274413
NC_022524.1\|WP_022544559.1\|4681963_4682419_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240033
NC_022524.1\|WP_022544560.1\|4684064_4684286_+\|hypothetical-protein	unknown	unknown	unknown
NC_022524.1\|WP_156917069.1\|4684325_4684880_+\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|377369
NC_022524.1\|WP_009794504.1\|4686070_4686721_-\|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	unknown	unknown	gnl\|CDD\|180618

Protein	Function_ID	Function_description	E-value
NC_022524.1\|WP_022544558.1\|4676290_4676983_+\|LrgB-family-protein	gnl\|CDD\|377236	pfam04172, LrgB, LrgB-like family. The two products of the lrgAB operon are potential membrane proteins, and LrgA and LrgB are both thought to control of murein hydrolase activity and penicillin tolerance.	2.24583e-78
NC_022524.1\|WP_009794499.1\|4683303_4684041_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	4.81297e-36
NC_022524.1\|WP_022544561.1\|4686839_4688225_-\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273919	TIGR01995, beta-glucosides_PTS_EIIBCA, PTS system, beta-glucoside-specific IIABC component. This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.	1.66674e-132
NC_022524.1\|WP_156917034.1\|4673755_4674394_-\|DUF3885-domain-containing-protein	gnl\|CDD\|379022	pfam13021, DUF3885, Domain of unknown function (DUF3885). A putative Rac prophage DNA binding protein. This domain family is found in bacteria, and is approximately 40 amino acids in length. There is a conserved YDDRG sequence motif. There is a single completely conserved residue D that may be functionally important.	1.0049e-07
NC_022524.1\|WP_009794503.1\|4685064_4686069_-\|sugar-kinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	2.42736e-87
NC_022524.1\|WP_009794485.1\|4671822_4672362_-\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	9.6345e-05
NC_022524.1\|WP_009794489.1\|4675319_4675757_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.92402e-17
NC_022524.1\|WP_009794498.1\|4682506_4683211_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	9.33884e-18
NC_022524.1\|WP_022544559.1\|4681963_4682419_-\|NUDIX-hydrolase	gnl\|CDD\|240033	cd04677, Nudix_Hydrolase_18, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	2.51722e-52
NC_022524.1\|WP_009794493.1\|4677770_4678379_+\|DUF1311-domain-containing-protein	gnl\|CDD\|377758	pfam07007, LprI, Lysozyme inhibitor LprI. This family consists of several bacterial proteins of around 120 residues in length. Members of this family contain four highly conserved cysteine residues. Family members include lipoprotein LprI from Mycobacterium, which binds to and inhibits macrophage lysozyme, which may aid bacterial survival.	5.83013e-10
NC_022524.1\|WP_009794494.1\|4679497_4680274_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	9.25634e-82
NC_022524.1\|WP_009794484.1\|4670676_4671552_-\|SMP-30/gluconolactonase/LRE-family-protein	gnl\|CDD\|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	7.80832e-107
NC_022524.1\|WP_035402941.1\|4675916_4676318_+\|CidA/LrgA-family-holin-like-protein	gnl\|CDD\|167253	PRK01658, PRK01658, CidA/LrgA family holin-like protein.	1.74502e-32
NC_022524.1\|WP_009794492.1\|4677039_4677459_-\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	7.98806e-33
NC_022524.1\|WP_022544556.1\|4672406_4673597_-\|ABC-transporter-permease	gnl\|CDD\|274413	TIGR03061, hypothetical_protein_lp_1332, YhgE/Pip N-terminal domain. This family contains the N-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03062, represents the conserved C-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.	2.59301e-13
NC_022524.1\|WP_156917069.1\|4684325_4684880_+\|restriction-endonuclease	gnl\|CDD\|377369	pfam04471, Mrr_cat, Restriction endonuclease. Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA.	1.10484e-12
NC_022524.1\|WP_009794504.1\|4686070_4686721_-\|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase	gnl\|CDD\|180618	PRK06552, PRK06552, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	1.09339e-117

>NC_022524.1|WP_009794493.1|4677770_4678379_+|DUF1311-domain-containing-protein
MENKGKHYIAIFAVLLVLLLAACESSSGVSNDESEKQQNNDSSQDTEHGSSGADSAEDDTNTGSTNTDDTASEKEEDPPANETEDSLKEEYLKKLNNSKKEADALEAADSSTYALKKVENDRWEIWDDRLNEIYGVLQERLPAEEMESLREEQRDWLKERDARALEASLKYEGGTQEHLEYVAVLADITEERCYELVENYMN
>NC_022524.1|WP_009794492.1|4677039_4677459_-|universal-stress-protein
MYQKILLATDGSEHSKRAAENAIHIAKCSSGSRIEIVYVADPDKAKSETLSHWNSANLGEGKKRRLAEVEKLAKESGVQYEIIVLDGDPGPCIVDYANKNKADIVIIGSRGLNVLQEFVLGSVSHKVAKRAACPVLIVK
>NC_022524.1|WP_022544558.1|4676290_4676983_+|LrgB-family-protein
MQSLIIAILMIFSTITIYMVMASVYKRYSYPVFIPVLTSTIIIVALLAGLHVPYKEYMTGGKWIHFLLGPAVTALAYPLYTQREVLKKYSLPVLGGVFTGLITGMITGMLFAMLLGMNHELILSLIPKSITTPVAMQIADGIGGIPSMTVIFVTLAGFSGVLLGPSIIKWVRIRSSLGRGIALGSASHGLGTSKASEYGEVSVSMSSVSMTLCALLGSVFGPVIVWLFHI
>NC_022524.1|WP_035402941.1|4675916_4676318_+|CidA/LrgA-family-holin-like-protein
MKWLQIVLQICVLYAFTFTGDVIQRAFHIPIPGSIIGLLLLLACLLLHIVPVIFVKDGASFLLSILPLLFIPSMAGVVNYPSLLSATGAVLAAIVVVSTIATIAAAGLMSQFLENRADKRKEKKACKALSSQS
>NC_022524.1|WP_009794489.1|4675319_4675757_-|MarR-family-transcriptional-regulator
MSKEKQNDVELIEYELATFIRKAVYLEQSEKKIGQLERSAYLLLRQLDEFGPARVKELAEAFKLDISTLSRQAASLESKDLIKRCSDPKDGRVSVFSITDLGKEKLEADIANRRAHYFKVLNDWTEEEKEIFGKLVVRLNTSFFE
>NC_022524.1|WP_009794488.1|4674403_4675207_-|hypothetical-protein
MLLYKISAYLMLAGLMCLLGDGIWIISSYEDPAPYPFAAYLWLFAGVLLMLISFTFMEVLKGKAGGSDSGFPGSKRKDMREYIQPLAAKAQNGDKRIWALLIAMVIILAAVFFAFPGFPLLDVVFTVIPAAVGAGFVLYMAKAEPEEDDEPGKAYRWLRFIDYRRHPLSLALLVFILMNLSLLLSKKYGISLVIDQEGYSPYATSLRTEFHLNAALLVSCACLYINQHAPFLGFYQKNTSHMVVVGIHFFEILVCGVGLFVLILSWF
>NC_022524.1|WP_156917034.1|4673755_4674394_-|DUF3885-domain-containing-protein
MMEVKAYLERTFPNLILKPSLYSQWNIGIHFELGNGIYQFKEDGELNLDLFETVYSQACSIFMSLFSEEDEMAVALNIYHPETDRTTKRPTKVFGHYLINKKLKYKIIHETLKHLLNDEEAGYTSRYYLKGRKSDFHCRKLIEAACNEDFLLKPRFGSAEVSYYPDIFFINMTRDIIFFIYDDRGCEVIAARTDSLRQLYGEYSEWVDEYHM
>NC_022524.1|WP_022544556.1|4672406_4673597_-|ABC-transporter-permease
MKFTQFLKTRGAIASIFMGIFYAAAMLGIFLPGYSAIPGNVDQMPIAIVNEDAGTYGAQIAGQLQENLPFKEIETDISNKQAIKDLNHNDLALVVRIPETFSADLQKGEGSTGIDFTINEASATTVSSTMKSVVGEINNQLRSQFSQQTAQGVLMNFNLPEDQAAEMAKKIETAYSGNVISINKIPAGMNNNMLPMFLTMAGYVGAMIGAMQLVAAFRESRGKASKTRLFLYVQLTALLIAVVSSAVAVGVAYLVNEPSGDLFFGIAGQQILNYMVCFNFTAVLVFLIGEGGMVLNLPILLMQTLANGATISREMMYAPFQWMSHISPMYYSVQAYMANMYSSISPSPYLWSMAAVGGAAMLINIAIVAFLHKPAPVVIPELDASDSLKAAGEVTA
>NC_022524.1|WP_009794485.1|4671822_4672362_-|transcriptional-regulator
MSIQIFILSKLMEDNNYPYKLKKQLSEPIPLDQLSGLTESKLYYHFDTLAKQGLIETVEIIKEEHRPDKQVFGITAKGREELPKKIYKEFEKSTGIGEMVVAIANIKYVDRGKVITILEKKLDAIKARWEQISSIDAEKHVGEAQQNIREFMEGYVSTRMEHTIHWLEELIRRVERKEI
>NC_022524.1|WP_009794484.1|4670676_4671552_-|SMP-30/gluconolactonase/LRE-family-protein
MGEAELVLDAKATLGEGPCWDAEKQLLYWVDIKEKKVNIFNPASGENREIQLDQNIGTIVPRNAEEAAVALEDGLYLLNLETEKLTLIKELESDIPSNRFNDGKCDPAGRFWAGTMDQQGAGAEGALYCLDTDQQVEKKLDQLGISNGLAWSPDNRFMYFIDTPTKKISRFDFDLGTGAIENRTEVISFPEGDGAPDGMTIDGEGMLWIAHYGGGKVSRWNPHTGKKLSEIKVPAKNVTCCTFGGEDLKDLYITTARDGLNEEQQKEYPLSGGLFRVKTDVKGSPAYSYKG
>NC_022524.1|WP_009794494.1|4679497_4680274_+|ABC-transporter-ATP-binding-protein
MEDIILEIEDLKKSYGSKPVLKGVSLQVKRGEIIGYIGPNGAGKSTTVKIMLGIEDGYSGGVKIFGQDISDGKIDYKRKIGYVPEIAEVYDNLTGHEYLTFIGELYGIDSDLASYKAKALMELFGIGEVYYSRITSYSKGMRQKLLIISSLLHNPDLLFFDEPINGLDANSVMIFKEIMAQLAVQGKTIFYSSHIMDVVEKISSRIILLHDGRIAADGTFEELQQKTEGSLEQIFNQLTGFSEHKELGARFVSIVGEM
>NC_022524.1|WP_009794495.1|4680276_4681923_+|hypothetical-protein
MQDFQTLKILDRFEWMFSRFGVDYKVMRMILQVKLTMDGRRVPTVFAQNARKAEDKEKSNQYIKSLWIYVLFGLFMIPFLLMGENYLFQMSLFYGIFTFFVMTAMISDFSTVLLDIRDRNILFPKPVDRKTINTAKMVHVVIYLSFLTIALATIPLFVGLFNIGPLFFLTAVINIILIDLFIVGLTALIYLAFLRFFDGEKLKDLINYVQIGLSLMIMVGYQLLIRSFAIIDFTVSLEPEWWQVFIFPMWFGANMELVLNGRFQPFYIIFTALSIVVPFLSIWIYTKFNSSFEQNLQKLAYHGSAKEKKRSKTGRFLLKVLCRSKEERAFFKFASSMMKNERDFKLKVYPSLGFSIVVPFLMIFSSFDTDLSRLEGSKSYLSIYFSMIIIPTIMLLLKYSGKYKGSWIFRAAPLDQLGPMFSGTIKAFILKLYLPIYSILSVLFVLLFGARVVPDLVVVFINACTYAVLCFMFLKTAIPFSESFDQYNQNGNGVIIFGLMLFAGLFAGLHYLSTLLPYGIYLYMAVALIYLAVFWKLAFRVTWKDVLE
>NC_022524.1|WP_022544559.1|4681963_4682419_-|NUDIX-hydrolase
MGYIEDLRTVVGNEPLILVGVAVAVINDMGEFLLQKRIDGRWGVPGGFIELGESTEEAGRREVLEETGIEIGRLDLAGVISGKEHYVKLPNGDEFYPVTIAYISRDMKGGVLKADGLETTEAKFFRADELPEGLNPMIKNLIKQYAQSLSQ
>NC_022524.1|WP_009794498.1|4682506_4683211_-|CPBP-family-intramembrane-metalloprotease
MGTDQMNWKTRDPWGWREFILLMLLEFIIVIGVVKLIVQPLYAEWLKDDLYAGTLTGLTIAVILMAGVYFTALRPKRLSWREVGVKGFALKDWKLIGLYSAVLLAGAVIIVVLTSFIGNTWENSKTEAMQQNVTFFTVLIAFISAAVISPIYEEIFYRGFLYRWLRTRMGLTGALLLSSLIFTIIHIPTYNVMPVNFFSGILFALAYERTGSIWPPVLIHGLTNGFMVLLTSLG
>NC_022524.1|WP_009794499.1|4683303_4684041_+|MerR-family-transcriptional-regulator
MKRWTTGEAAKQRNVSVRTLRYYDQIGLLAPSFKDENGKRHYSEEDLFTLEKILILKSLSLPLEEIREVLKQLSYKQILVSHYNHLQEQLSELQTSISNTASLINMTDLEDSLSWDRVAELVQNSQKRSKKWTDYFQEEEIAFLEKTIPNLGSNDEITQQYVSLLRRIEWCVEHHITAESEEGFEIASELIHLSNKSFQGDTELMDQFWEVRKMPAEETGLYPVSEEVLEFVERCLAYAGSRAGS
>NC_022524.1|WP_022544560.1|4684064_4684286_+|hypothetical-protein
MKKNKQVQMMLAIIGSIAILTIGTVMVIQIAKNHQVNKQIIDQCFESFDTERTVTIKKEGFWSPVFCEKHPGA
>NC_022524.1|WP_156917069.1|4684325_4684880_+|restriction-endonuclease
MNNRVHIFVWITMIAVPFFSFIKTGNGETAVFIFISEVILYFIYALFRLRRMTKRQEDSEVWVTDKMTDEELKEFTIPLLAKSGYTISRLEREHPDISFLLETPAGKKAIVKVKSHKRGVGIRLVQRIFKQLDAYDADECWVITNYGYTPQASEYARKLPIRLYAREKFMDWILAVRRGKRIRG
>NC_022524.1|WP_009794503.1|4685064_4686069_-|sugar-kinase
MSRILTLGEIMLRLSTRVDTRLSESKQFQVHYGGGEANVAISLANYNHSVSFASKVPNNALGLAVKRHLQQYGVSTDLLLFGGTRLGSYYLESGVGERSSSVIYDRAYSSFSEIEMLEWSMDELFGDVELFHVSGITPALSDNWAKLTEQLMKEAKKRSVKISFDINYRAKLWSYIKAKSILPALLPYADYCSAGKLDAIHLLGIEEQSKDGEDVANYYQQMSDLYPNIEMFYSTLREIKSTSDHILKGTIWNKGVLYASKKHFIVPVIDRVGGGDAFSAGIIHGLLTKQDLDYTVSFATAASAMKHTITGDCNQFSIEEIEEFMTRDDQRIKR
>NC_022524.1|WP_009794504.1|4686070_4686721_-|bifunctional-4-hydroxy-2-oxoglutarate-aldolase/2-dehydro-3-deoxy-phosphogluconate-aldolase
MKKIAILNKLINSGVIAVIRADSKKEALGITEAIVNGGFTGLELTFTIPDAEGAIREIKEKYADHDQLVIGAGTVLDATTARIAIMAGAEYIVSPFFDQQTAECCHLYQIPYLPGCMSITEISHALKAGVDIIKLFPGSGFGPGFISAIKAPLPQANIMPTGGVSLENMEQWFANGSMAVGVGGSLLAPAKTGDFEEITKLARQYMDKLKAIRGDL
>NC_022524.1|WP_022544561.1|4686839_4688225_-|PTS-transporter-subunit-EIIC
MKERDTVRNIIEHVGGKENIKKAWHCMTRLRFDLYDDSLIQHEKVKQLTGVIGEQLQSDQYQIIMGTNVQKYYSLLVEELGIDEIDESEQESNKKKGLFSRLLDVVSGVFGPIVPAIAGAGMVKGIIAGLIALNVLSADTETVKILDLIASSVFYFLPFFIAASAAKIFKTNQYLAIAIAAGFMYPTLNDAAKLGEVSQFHFIGLPIPVINYAGNVIPVILSIWALSFIHRLVDKYMPSVLKTVFTPTLTLLIGLPFALIVSGPLGSYVGKGLAFIVQSLFDISPVLAGVVMGGLRPIEIVFGVHHAMTPIALQNFADKGYDMLMPMMFMTNMAIAGATFAMFFKAKSKAEKSIILSATISALLGITEPALFGVLIKNRKSFIGCSIGSAIAATFFAIMGVRIYGYILSSIVSLVAYVGPYFTYALIGIAIAIGTSFVITYFAVKNNKENPHSNFTLKEIG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2102961 : 2114957

Catovirus(37.5%)

coat

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_009790833.1\|2102961_2104098_-	sulfate adenylyltransferase	A0A2K9L0F0	Tupanvirus	2.2e-49	32.6
WP_009790834.1\|2104103_2104742_-	adenylyl-sulfate kinase	A0A2P1ELS9	Moumouvirus	6.7e-24	37.9
WP_022543806.1\|2104732_2106496_-	SLC13 family permease	NA	NA	NA	NA
WP_022543807.1\|2106739_2107831_+	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	A0A2P1ELS7	Moumouvirus	4.6e-89	45.3
WP_009790838.1\|2107823_2108813_+	NAD-dependent epimerase/dehydratase family protein	A0A1V0SAI8	Catovirus	1.3e-39	30.8
WP_009790839.1\|2108809_2109637_+	SDR family oxidoreductase	A0A1V0SAG7	Catovirus	3.8e-27	32.7
WP_083783053.1\|2109618_2110572_+	NAD-dependent epimerase/dehydratase family protein	NA	NA	NA	NA
WP_009790841.1\|2110568_2111273_-	glycosyltransferase	A0A1V0SAH6	Catovirus	3.4e-05	26.3
WP_009790842.1\|2111431_2112661_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_009790843.1\|2112704_2113163_-\|coat	spore coat protein	NA	NA	NA	NA
WP_009790844.1\|2113152_2114004_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	3.3e-34	36.2
WP_009790845.1\|2114000_2114957_-	dTDP-glucose 4,6-dehydratase	K7QJG5	Escherichia_phage	3.6e-74	46.0

DBSCAN-SWA_2

2395016 : 2402903

Bathycoccus_sp._RCC1105_virus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_009793688.1\|2395016_2396756_+	AAA family ATPase	E5ESM9	Bathycoccus_sp._RCC1105_virus	1.6e-72	35.5
WP_009793687.1\|2396991_2397282_+	hypothetical protein	NA	NA	NA	NA
WP_009793686.1\|2397326_2397905_-	peptide deformylase	E3SLL2	Synechococcus_phage	4.1e-12	42.2
WP_009793685.1\|2398027_2399299_+	sporulation kinase B	Q8QKV7	Ectocarpus_siliculosus_virus	1.9e-06	23.3
WP_022543891.1\|2399335_2399746_-	hypothetical protein	NA	NA	NA	NA
WP_009793683.1\|2400031_2400676_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_009793682.1\|2401053_2401779_-	7-carboxy-7-deazaguanine synthase QueE	E7DN68	Pneumococcus_phage	3.7e-55	48.0
WP_009793681.1\|2401771_2402245_-	6-carboxytetrahydropterin synthase QueD	J9PV91	Bacillus_phage	1.1e-63	75.2
WP_009793680.1\|2402246_2402903_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	1.9e-66	58.3

DBSCAN-SWA_3

3970389 : 3977117

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_022544379.1\|3970389_3970896_-	hypothetical protein	A0A1U9WQI6	Geobacillus_phage	3.3e-26	55.6
WP_009793069.1\|3971230_3971836_+	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	2.6e-54	57.1
WP_009793068.1\|3971951_3972209_-	HPr family phosphocarrier protein	NA	NA	NA	NA
WP_009793067.1\|3972239_3973190_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	1.7e-52	38.1
WP_009793066.1\|3973231_3974215_-	YvcK family protein	A1IMD5	Streptococcus_phage	2.9e-66	42.5
WP_009793065.1\|3974211_3975105_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	1.6e-07	32.8
WP_009793064.1\|3975134_3975593_-	8-oxo-dGTP diphosphatase	NA	NA	NA	NA
WP_009793062.1\|3976166_3977117_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	3.4e-88	54.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022524

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection