CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022571	Clostridium saccharobutylicum DSM 13864, complete sequence	8 crisprs	cas3,cas14j,DEDDh,WYL,c2c9_V-U4,csa3,RT,cas6,cas8b1,cas7b,cas5,cas2,cas1,cas4,DinG	1	14	10	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022571_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022571_1

148425-148574

Unclear

Consensus_repeat	Method
AAATATCGCGGGGTGGAGCAGTTGGTAGCTCGTCGGGCTCATAACCCGAAGGTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022571_1

>merge|NC_022571|1|148425-148574|CRISPRCasFinder
AAATATCGCGGGGTGGAGCAGTTGGTAGCTCGTCGGGCTCATAACCCGAAGGTCGCAGGTTCAAGTCCTGTCTCCGCAACCATTATATATAAAATAAATATCGCGGGATGGAGCAGTTGGTAGCTCGTCGGGCTCATAACCCGAAGGTCG

>NC_022571|1|1|148425-148574|CRISPRCasFinder
AAATATCGCGGGGTGGAGCAGTTGGTAGCTCGTCGGGCTCATAACCCGAAGGTCG	CAGGTTCAAGTCCTGTCTCCGCAACCATTATATATAAAAT
AAATATCGCGGGATGGAGCAGTTGGTAGCTCGTCGGGCTCATAACCCGAAGGTCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022571.1\|WP_022743505.1\|163758_165150_+\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NC_022571.1\|WP_022743493.1\|146495_146888_+\|spore-cortex-biosynthesis-protein-YabQ	unknown	unknown	gnl\|CDD\|131939
NC_022571.1\|WP_022743499.1\|154084_155893_+\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NC_022571.1\|WP_002582985.1\|145338_145614_+\|HU-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|259853
NC_022571.1\|WP_022743500.1\|156370_158041_+\|formate--tetrahydrofolate-ligase	unknown	unknown	gnl\|CDD\|376511
NC_022571.1\|WP_022743488.1\|141452_142004_+\|stage-V-sporulation-protein-T	unknown	unknown	gnl\|CDD\|131898
NC_022571.1\|WP_022743491.1\|145685_145946_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NC_022571.1\|WP_022743487.1\|140493_141015_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|130902
NC_022571.1\|WP_022743489.1\|142113_143652_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NC_022571.1\|WP_022743498.1\|153473_154013_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NC_022571.1\|WP_022743504.1\|160872_162378_+\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NC_022571.1\|WP_022743494.1\|146967_147261_+\|septum-formation-initiator-family-protein	unknown	unknown	gnl\|CDD\|368217
NC_022571.1\|WP_022743501.1\|158170_158986_+\|type-III-pantothenate-kinase	unknown	unknown	gnl\|CDD\|237347
NC_022571.1\|WP_022743495.1\|147417_147822_+\|RNA-binding-protein-S1	unknown	unknown	gnl\|CDD\|235614
NC_022571.1\|WP_022743492.1\|146192_146486_+\|sporulation-protein-YabP	unknown	unknown	gnl\|CDD\|274341
NC_022571.1\|WP_022743503.1\|160376_160859_+\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NC_022571.1\|WP_022743497.1\|152062_153472_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|238950
NC_022571.1\|WP_022743496.1\|149457_151854_+\|stage-II-sporulation-protein-E	unknown	unknown	gnl\|CDD\|274328
NC_022571.1\|WP_022743502.1\|158960_159926_+\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NC_022571.1\|WP_022743490.1\|143668_145120_+\|nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|226465

Protein	Function_ID	Function_description	E-value
NC_022571.1\|WP_022743505.1\|163758_165150_+\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NC_022571.1\|WP_022743493.1\|146495_146888_+\|spore-cortex-biosynthesis-protein-YabQ	gnl\|CDD\|131939	TIGR02893, Spore_protein_YabQ, spore cortex biosynthesis protein YabQ. YabQ, a protein predicted to span the membrane several times, is found in exactly those genomes whose species perform sporulation in the style of Bacillus subtilis, Clostridium tetani, and others of the Firmicutes. Mutation of this sigma(E)-dependent gene blocks development of the spore cortex. The length of the C-terminal region, including some hydrophobic regions, is rather variable between members. [Cellular processes, Sporulation and germination].	5.72516e-15
NC_022571.1\|WP_022743499.1\|154084_155893_+\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NC_022571.1\|WP_002582985.1\|145338_145614_+\|HU-family-DNA-binding-protein	gnl\|CDD\|259853	cd13831, HU, histone-like DNA-binding protein HU. This subfamily includes HU and HU-like domains. HU is a conserved nucleoid-associated protein (NAP) which binds non-specifically to duplex DNA with a particular preference for targeting nicked and bent DNA. It is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein. HU can induce DNA bends, condense DNA in a fiber and also interact with single stranded DNA. It contains two homologous subunits, alpha and beta, typically forming homodimers (alpha-alpha and beta-beta), except in E. coli and other enterobacteria, which form heterodimers (alpha-beta). In E. coli, HU binds uniformly to the chromosome, with a preference for damaged or distorted DNA structures and can introduce negative supercoils into closed circular DNA in the presence of topoisomerase I. Anabaena HU (AHU) shows preference for A/T-rich region in the center of its DNA binding site.	1.1023e-41
NC_022571.1\|WP_022743500.1\|156370_158041_+\|formate--tetrahydrofolate-ligase	gnl\|CDD\|376511	pfam01268, FTHFS, Formate--tetrahydrofolate ligase.	0
NC_022571.1\|WP_022743488.1\|141452_142004_+\|stage-V-sporulation-protein-T	gnl\|CDD\|131898	TIGR02851, stage_V_sporulation_protein_T, stage V sporulation protein T. Members of this protein family are the stage V sporulation protein T (SpoVT), a protein of the sporulation/germination program in Bacillus subtilis and related species. The amino-terminal 50 amino acids are nearly perfectly conserved across all endospore-forming bacteria. SpoVT is a DNA-binding transcriptional regulator related to AbrB (See pfam04014). [Regulatory functions, DNA interactions, Cellular processes, Sporulation and germination].	8.64174e-96
NC_022571.1\|WP_022743491.1\|145685_145946_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	6.29196e-28
NC_022571.1\|WP_022743487.1\|140493_141015_+\|hypothetical-protein	gnl\|CDD\|130902	TIGR01843, Hemolysin_secretion_protein_D_plasmid, type I secretion membrane fusion protein, HlyD family. Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking].	4.81533e-12
NC_022571.1\|WP_022743489.1\|142113_143652_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	3.23304e-130
NC_022571.1\|WP_022743498.1\|153473_154013_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	8.14781e-87
NC_022571.1\|WP_022743504.1\|160872_162378_+\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NC_022571.1\|WP_022743494.1\|146967_147261_+\|septum-formation-initiator-family-protein	gnl\|CDD\|368217	pfam04977, DivIC, Septum formation initiator. DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation. These proteins are mainly composed of an amino terminal coiled-coil.	1.67965e-09
NC_022571.1\|WP_022743501.1\|158170_158986_+\|type-III-pantothenate-kinase	gnl\|CDD\|237347	PRK13318, PRK13318, type III pantothenate kinase.	7.33279e-157
NC_022571.1\|WP_022743495.1\|147417_147822_+\|RNA-binding-protein-S1	gnl\|CDD\|235614	PRK05807, PRK05807, RNA-binding protein S1.	4.77606e-76
NC_022571.1\|WP_022743492.1\|146192_146486_+\|sporulation-protein-YabP	gnl\|CDD\|274341	TIGR02892, conserved_hypothetical_protein, sporulation protein YabP. Members of this protein family are the YabP protein of the bacterial sporulation program, as found in Bacillus subtilis, Clostridium tetani, and other spore-forming members of the Firmicutes. In Bacillus subtilis, a yabP single mutant appears to sporulate and germinate normally (), but is in an operon with yabQ (essential for formation of the spore cortex), it near-universal among endospore-forming bacteria, and is found nowhere else. It is likely, therefore, that YabP does have a function in sporulation or germination, one that is either unappreciated or partially redundant with that of another protein. [Cellular processes, Sporulation and germination].	4.09833e-25
NC_022571.1\|WP_022743503.1\|160376_160859_+\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	9.64609e-74
NC_022571.1\|WP_022743497.1\|152062_153472_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	1.0741e-73
NC_022571.1\|WP_022743496.1\|149457_151854_+\|stage-II-sporulation-protein-E	gnl\|CDD\|274328	TIGR02865, Stage_II_sporulation_protein_E, stage II sporulation protein E. Stage II sporulation protein E (SpoIIE) is a multiple membrane spanning protein with two separable functions. It plays a role in the switch to polar cell division during sporulation. By means of it protein phosphatase activity, located in the C-terminal region, it activates sigma-F. All proteins that score above the trusted cutoff to this model are found in endospore-forming Gram-positive bacteria. Surprisingly, a sequence from the Cyanobacterium-like (and presumably non-spore-forming) photosynthesizer Heliobacillus mobilis is homologous, and scores between the trusted and noise cutoffs. [Cellular processes, Sporulation and germination].	0
NC_022571.1\|WP_022743502.1\|158960_159926_+\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	1.29996e-133
NC_022571.1\|WP_022743490.1\|143668_145120_+\|nucleoside-triphosphate-pyrophosphohydrolase	gnl\|CDD\|226465	COG3956, COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only].	0

>NC_022571.1|WP_022743495.1|147417_147822_+|RNA-binding-protein-S1
MTLMAGNIVEGTVINITNFGAFIEVEGKTGLVHISEVADSYVKDIREHLSEQDKVKVKVISIDDNGKISLSIKQANVQKKSVKPAEIDWKSPEKKKAAGNFEDIMSKFLKDSEERMQDVKKHQEFKGKGGKKGV
>NC_022571.1|WP_022743494.1|146967_147261_+|septum-formation-initiator-family-protein
MKNKLMIKKLIIVGFIIFFAFSYIRQRIEINRIEKEIANKQSQLQDVKEKNERLQDEVEKINSDSLDYLEKLARERLGMIKPGEKVVNSSTTESSSN
>NC_022571.1|WP_022743493.1|146495_146888_+|spore-cortex-biosynthesis-protein-YabQ
MPLQLSMQFNLVIYSLIAGIITGILFDMYRAIRGFSSIKILTIIEDILFWILAALIVFTFLLYTNYAFLTPYVYIFIVVAILLYLKLISRHFYSSEKIIIKFIAKIIRILLKNICYPLKIIAYKVTDKKK
>NC_022571.1|WP_022743492.1|146192_146486_+|sporulation-protein-YabP
MEKRLENKIEDNKSNLALENRKKLTLSGVIEVISFDEQKIDLTTNLGNLTIKGEELKMNKLDVQNGDVIIVGNIASMVYNGKIAKKNNESIISRLFK
>NC_022571.1|WP_022743491.1|145685_145946_+|RNA-binding-S4-domain-containing-protein
MRLDKYLKVSRIIKRRTVAKEVCESGRILINDKVAKPSTKIKEGDIIQITFANRILKAEIINIAEHVRKEDAKQMYIIIEGEEDKE
>NC_022571.1|WP_002582985.1|145338_145614_+|HU-family-DNA-binding-protein
MNKAELITSMAEKSKLTKKDAELALKSFIESVEEALENGEKVQLVGFGTFETRERAAREGRNPRTKEVINIPATTVPVFKAGKEFKDKVNK
>NC_022571.1|WP_022743490.1|143668_145120_+|nucleoside-triphosphate-pyrophosphohydrolase
MIKIVGLGPGAKEALTVGTIIELENNKNIFLRTEKHPTVDYLEEKNIKFGTYDNVYESMDSFDEVYLSIANDLIEKHKKLGDLVYAVPGHPLVAEKSVFNLINLCKKNNIEYKVMPAVSFIDAMMEALMIDPIEGLKVIDAFDINNQVLDKRIGTIITQVYNPLIASEVKLKLLEQYNDETEIYFVRAARIQGQESIRVIPLFELDMQEDIDYLTSIYIPKDLNNKRDFNDLLDIIEVLRGENGCPWDREQTHKSLEKALVEESYEVIDAIEKDDDNSLIEELGDVLLQVVFHASIGKEDGYFDIGDIIEGICNKMISRHPHVFRNSNKIDSSEEVIEKWEDLKKKEKGYESLTEEMNGITKGLPSLLRAHKIQQKAKKVGFDFEDLNSVINKVKEELEEVIDVYNTKNMEKIKEEVGDLLFSCVNVARFLNIDEEIALNFTADKFIKRFDYIERMAKEKGIKLVDMKLNEMDKLWVESKKLD
>NC_022571.1|WP_022743489.1|142113_143652_+|polysaccharide-biosynthesis-protein
MRKQSLMKASIILGISGILTRFLGLFFRWPLIMLIGDEGIGYYQMSYPLYMFFIAIASGVPVAISKMISEKNAINDLNGTFEVVKESAMLMMIIGTGTTLSLFFFAKPIISFLKWDAKAYYSLIGISFAPVMISFMTIFRGFFQGLQNMTPSAISQIIEQMGRVVFGVGLAVFLLPKGIEYSAGGAAFGATAGAVIGSSYLYSKYRKIKKSYGIKKVKSNPEVLNNILKIAIPISLGTTVGSIMNLIDSILVPQKLLQAGFTNTQSTVLYAQLTGKASVIVNVPLTLSMAICTSLIPIIAENFILKKQNELENKIDASMKMAAVIAIPCMFGLFFLTEPIMKFIFPGRFEGIEILKYLSLSIPFIIITQTTTSILQGTGNYIRPVINLLTGCVVKVILTCMLVPMAVFNIYGAVIASVGAYVVTSILNLITMKLMLKVKLNLYQIIIKPAYASTIMMLIVLMSYNIIYRNTISNGISCLISIFLGMIVYMILVVVFKIFKIEEIRDRFRRRM
>NC_022571.1|WP_022743488.1|141452_142004_+|stage-V-sporulation-protein-T
MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFTDRDGGVILKKYSPIEELTDFSKEYCESLQQVIGHIVLIADKDAFVSVSGVPKKEYIERKVSSELEKIMDERKTVLLNKSAGTVIPLHNDDDEASYTSQVIAPIIAEGDEIGAVIILSKEVDVELGDVETKLVETAAAFLGKQMEQ
>NC_022571.1|WP_022743487.1|140493_141015_+|hypothetical-protein
MKYKIENLEEITDAKDIMNAYLNSCSYKLLKYILYIVMSFLICIMVWSIFAKKTIVISAHGELHPKDNICNIYIKNTSLGTIKEGDRVQLETIPFSKNEYGVITSKLENISDDIVIDEKSGEKYYTADCKLDTNILVDKRGNNVNIRNGMEANVSIVTYETSYFKYILKKLIQ
>NC_022571.1|WP_022743496.1|149457_151854_+|stage-II-sporulation-protein-E
MQYGLDVDKYEEISSEPRIKRKTWIKTIAIKLTTILVVGILISRVSLLLNQSDSHGIAPFGIAYLMAVVIKGNKRNNLAAAVGCVLGYLTINNLLTDGYVYLVAIIIMTIYYSFVSTARKRKKELIGFITILFSFFIYGLLVNKYELGVNVTLCLIQTLVIVPIYYVINYALDSLSEISTNYFFNSEEIISIGIFLCLLVAGIGDINLMNYSIRNVIALVLVLATAYIGGASYGAMIGVSMGIILGVASNDMMSCVGFFGVGGLIVGIFKDTGKIFSILAGIIIYFALGLYSDSLTLKLAVEVLTSSILFLCVPKSTYKSIEIEINPDRKKQCLSENKINGIKGEFTFKLKELTRVLATVSKYLGSCNENENLLIKAKGSALVENLADRACSKCENKSVCWERDFHQTYNSFQLLIQSYEKGNIEIPKDLEKRCVKNFGLLKSTESIVDNYTVNETVKERLAEGRHLLSEHITNISSTLDNLLNEFKKEVIIDNDLEKIIRRGLNKNSIDYKDVLCYTDIVGRIKIRISMNNCKGADYCGSTVVPLLSETVKMPLCVSDDGCSINPQTNECVITIEEIPKYYMVSYCAVKSKSGESETGDNYSFGKTINGCYMTILSDGMGSGPEAGQESKATVDLVEKFVEAGFNEDVTVNTVNSIMGMRFAEDEKYATLDLTRVNLYNGEANFVKIGAAPSFIKRGREVKAINSKNLPFGLVDEVDVEIVKERLKPGDILISVSDGVLDIDRFNSEGFIWLKEYLKNINSDPKELSELILNKAKELSDEMIKDDMTVLVSKIYLAG
>NC_022571.1|WP_022743497.1|152062_153472_+|tRNA-lysidine(34)-synthetase-TilS
MYKKVLSYIKDNNLIEFGDKVLVAVSGGPDSICLLNILFKLKEELNIDIGVAHLNHMLRGEDAFGDEEYVINTCEKMNIPCFVKRMDIETYSKEQKLSCEMAGRNARYDFFDEIMKKEGYSKVATAHNANDQAETILFRLMRGTGLEGLGGIKASRDNKIVRPILCLSRKEVEDYIQVNNLNPRIDKTNFEKIYNRNKIRLDILPYMKKNFNDDIIQTLNRMSILIQKDNQFIEKIALSFYNKYCIESKDYFIIKKEMFEEDEVVINRVLRNAITKYSKSNYDFEMKHIYEILQLSKKNSGKIIDLPNKIYAENIYGDIYIKHRKEKNFNSNEKKQEINIDKGNVNNNTIDFNDFKIEFLVIENYNNTKLNLEKNNFIKYFDLDQIIKNISVRNRKDGDKIIPLGMSGSKKLKDIFIDMKIPKEDRDNVPILCFDDKIAWIVGLKVSEQFKITNKTKNILKVVIQRKEY
>NC_022571.1|WP_022743498.1|153473_154013_+|hypoxanthine-phosphoribosyltransferase
MKEDIQEILFSEEVLTKRIKELADGISKDYKGKDLVVVGILKGSVIFAAELIKNISVHCEIDFMAVSSYGNSAQTSGVVRILKDLDHNIEGKDILLVEDIVDTGVTLSYLLKYLKARKANSIEIVSLLNKQARRVADLDVKYIGFEVPDGFIVGYGIDYAEKYRNLPFVGILKPEVYKK
>NC_022571.1|WP_022743499.1|154084_155893_+|ATP-dependent-zinc-metalloprotease-FtsH
MKKYSSAAVWIVCSVMLVLAAVTMWQTGKGSNDMTYSAFVQKWNANEIESVVIKEDKMTIEGKTTDNKSFVTYIPSQIVNSLIENQPKTDVRIDFEPPSNNATWVATLLPCVLLAVVIFIFLFMFTQQSQGGGGGRGVMNFGKSKAKMVTPESQTVTFDDVAGADEEKAELEEIVDFLKLPSRYVQMGARIPKGVLLVGPPGTGKTLLAKAIAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEEAKKNAPCIVFIDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGINEGIIMIAATNRPDILDPALLRPGRFDRQIVVGAPDVKGREEILKVHTKKKPLGESVNLNVLAKRTPGFSGADLENLANEAALLAVRRDKKEISMEEMEEAITRVIAGPEKKSRVITEHDKKLTAYHEAGHAVVMKLLPNCDPVHEISIIPRGRAGGYTMHLPKEDTSYTSKSKLKDEMVGLLGGRVAEKLIMGDISTGAKNDIDRASHIAKSMVMDYGMSDEIGTISYNTTGHDEVFLGRDLGKSRDFSEEVGAKIDKEIKRFIDEAYDTANKLLKSNTNKLHAVAQALIEKEKLDANEFEDIFANS
>NC_022571.1|WP_022743500.1|156370_158041_+|formate--tetrahydrofolate-ligase
MKSDIQIAQEAKMEPIKNVAKKLGLCEDDIEYYGKYKCKISLDVYDKVKDNKDGKLILVTAINPTPAGEGKSTVTVGLGQALNKLGKKAVIALREPSLGPVFGIKGGAAGGGYAQVVPMEDINLHFTGDMHAITCANNLLSAAIDNHIHQGNDLRIDSRRIIFKRVIDMNDRALRHIVVGMGGKVNGFVREDGFTITVASEIMAILCLAENLDDLKERMGNILVAYNLDGNPIYAKELEVQGAMALLMKDAIKPNLVQTLENTPALIHGGPFANIAHGCNSVMATKLALKLGDVAITEAGFGADLGAEKFFDIKCRYAGIKPECVVIVATIRALKHHGGVLKTELNVPNVDALAKGITNLEKQIENINKFNVTPVVAINRFVTDSDEEIQFIKDFCDKIGVKVALSDVWAKGGEGGIELGNIVLDVLENNNSSFAPIYDEKATIEEKVLTIAREIYGARGVNYTPAAKKQIAEIEKFGLDKLPICMAKTQYSLSDNASLLGRPEGFDINVNEVRVSNGAGFIVVQNGNIMTMPGLPKVPAANKMDVLKDGKIIGLF
>NC_022571.1|WP_022743501.1|158170_158986_+|type-III-pantothenate-kinase
MILLVDAGNTNIVLGVHDGERYIASWRISSDGSKTSDEYSIQVMQLFSLSDINPKDIDGVIVSSVVPNIMHSLENMLRKCFSHEPIIVGPGIKTGINIKYDNPREVGADRIVNAVAAYEIYKKPVIIIDFGTATTFCAVRANGNYLGGCICPGIRISADALFERAAKLPRVELEVPKNIICKNTITSMQAGIIFGYIGQVEYIVKKMKEEMKKGNCNEEPFVIATGGLANLIAKETNIIDKVDSDLTLEGLKILYEKNKEQILDENRKFNL
>NC_022571.1|WP_022743502.1|158960_159926_+|tRNA-dihydrouridine-synthase-DusB
MKIGNLTFDNNVFLAPMAGVTDISFRGLCKEMGCGLVYTEMVSAKALYYGSENTQALLRIADEEKPVAAQIFGRDPEIMASICEEHLNHRDDICIIDINMGCPAPKIVKNGEGSALMNEPELAYEIVKAIKKISTKPVTVKFRKGFDEDNINAVEFAKGMEQAGVDAVAIHGRTRKQMYQGKADWDIIKKIKDSVSIPVIGNGDVFTPEDALRMKELTNCDAIMVARGSQGNPWLFKQIANVLNGETIEEVSNKEKVEMCLRHYQLAIKYDGEYKAIREMRKHASWYIKGLPRCTDIRNSINVLDDSDKVIEILTKYKDEL
>NC_022571.1|WP_022743503.1|160376_160859_+|transcription-elongation-factor-GreA
MSEAKQYVMTYEGVKKLEGELDYLKTVKRKEITEKIKVALGYGDLSENSEYDEAKNDQAFTEGRIVQLENMLKNAVVVDESEIPKDIVSVGSKVKVKDYEFDEEVEYSIVGSAEADPMNFKISNESPVGKALVGKKVGEIVEVVVPDGMNKFEILGISRS
>NC_022571.1|WP_022743504.1|160872_162378_+|lysine--tRNA-ligase
MSTEEMSMQELESQYNEQEGLRRDKLAELQKEGKDPFDVYKVERTHTSEQVKEKYDELEGKEVTVAGRIMSKRGQGKVVFSDIYDKDGKIQLFLKIDKVGEENLKQYKTFDLGDWVAATGEVFKTRTGEVTVNVNTFELTCKSLKPLPEKWHGLKDPDLRYRQREVDIITNSEVKDTFIKRSKVVSGIREFLENKGFLAVETPILAPIAGGAAAKPFITHHNTLDMDMYLRIAPELYLKRLIVAGFEKVYEMGRNFRNEGMSVRHNPEFTSIELYEAYSDYNDMMEITENMVAYVCEKINGTTKVTYQGTEIDFKPPWRRITMVDAVKEYGGVDFNEIKTNEEAQAIAKEKHLEFPKPLEKVTKGEVLNALYEEFGEANMIQPTFVMDYPVEISPLTKKKRGNPEFTERFEGFVFGRELCNAYSELNDPIVQRQRFEQQANERELGDDEAYMMDEQFMSALETGMPPTGGMGMGIDRLIMFLTDSASIRDVILFPTMRPQK
>NC_022571.1|WP_022743505.1|163758_165150_+|glycine--tRNA-ligase
MAVEKTMDKIVALCKNRGFVFPGSDIYGGLANSWDYGPLGVEFKNNVKKAWWKKFVQESPYNVGLDSAILMNREVWVASGHVGGFSDPLMDCKECKARFRADKLVEDHMTANGAEVASADGWTNEELKEYIEKHEIVCPKCGKMNYTEIRKFNLMFKTFQGVTEDAKSEIYLRPETAQGIFVNFKAVQRTSRKKVPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGTDLEWHKYWKDYCWNFLLNLNVKPESLRMRDHGEEELSFYSNATSDIEYLFPFGWGELWGIADRTDYDLNKHQEHSGQDLSYLDQTTNEKYMPYVIEPSLGADRVALAFLVEAYDEEELEGGDVRTVMHLHPALAPFKAAILPLSKKLSERALDIYADLSKKFNLDFDETGSIGKRYRRQDEIGTPYCITIDFDTIEDESVTIRNRDTMEQERVKISELENYIQKSLEF

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Crispr_ID: NC_022571_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022571_2

1658957-1659039

Orphan

Consensus_repeat	Method
ATGGATATATGAAAACAGGTTGG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NC_022571_2

>merge|NC_022571|2|1658957-1659039|CRISPRCasFinder
ATGGATATATGAAAACAGGTTGGGTTAAAGATGGAGACAAATGGTATTTCTTAAATTCAAATGGATATATGAAAACGGGTTGG

>NC_022571|2|2|1658957-1659039|CRISPRCasFinder
ATGGATATATGAAAACAGGTTGG	GTTAAAGATGGAGACAAATGGTATTTCTTAAATTCAA
ATGGATATATGAAAACGGGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022571.1\|WP_022744758.1\|1657284_1658418_+\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022744760.1\|1659658_1659970_+\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022744751.1\|1647944_1648487_-\|NADH-peroxidase	unknown	unknown	gnl\|CDD\|153105
NC_022571.1\|WP_022743471.1\|1661334_1662573_+\|IS256-family-transposase	unknown	unknown	gnl\|CDD\|307151
NC_022571.1\|WP_022744757.1\|1655776_1656952_-\|beta-glucanase-Bgc	unknown	unknown	gnl\|CDD\|366548
NC_022571.1\|WP_041716167.1\|1660108_1661170_+\|iron-containing-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|341453
NC_022571.1\|WP_022744749.1\|1645675_1647250_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|270327
NC_022571.1\|WP_140395263.1\|1649464_1650118_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319798
NC_022571.1\|WP_022744766.1\|1666676_1667207_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NC_022571.1\|WP_022744752.1\|1648756_1649296_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|380316
NC_022571.1\|WP_022744764.1\|1665401_1665542_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182117
NC_022571.1\|WP_041716163.1\|1654721_1655519_+\|sel1-repeat-family-protein	unknown	unknown	gnl\|CDD\|223861
NC_022571.1\|WP_022744765.1\|1665641_1666397_-\|exonuclease-domain-containing-protein	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99836
NC_022571.1\|WP_022744768.1\|1668207_1669611_+\|L,D-transpeptidase/peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|341130
NC_022571.1\|WP_022744755.1\|1651837_1654186_+\|bifunctional-glutamate--cysteine-ligase-GshA/glutathione-synthetase-GshB	unknown	unknown	gnl\|CDD\|179427
NC_022571.1\|WP_022744763.1\|1664766_1665180_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NC_022571.1\|WP_022744754.1\|1650335_1651409_+\|transglutaminase	unknown	unknown	gnl\|CDD\|376628
NC_022571.1\|WP_022744762.1\|1662775_1664650_-\|anaerobic-carbon-monoxide-dehydrogenase-catalytic-subunit	unknown	unknown	gnl\|CDD\|130763
NC_022571.1\|WP_022744767.1\|1667266_1667416_-\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022744750.1\|1647581_1647908_-\|DUF1540-domain-containing-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022571.1\|WP_022744765.1\|1665641_1666397_-\|exonuclease-domain-containing-protein	gnl\|CDD\|99836	cd06133, ERI-1_3'hExo_like, DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins. This subfamily is composed of Caenorhabditis elegans ERI-1, human 3' exonuclease (3'hExo), Drosophila exonuclease snipper (snp), and similar proteins from eukaryotes and bacteria. These are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. ERI-1 has been implicated in the degradation of small interfering RNAs (RNAi). 3'hExo participates in the degradation of histone mRNAs. Snp is a non-essential exonuclease that efficiently degrades structured RNA and DNA substrates as long as there is a minimum of 2 nucleotides in the 3' overhang to initiate degradation. Snp is not a functional homolog of either ERI-1 or 3'hExo.	1.79873e-46
NC_022571.1\|WP_022744751.1\|1647944_1648487_-\|NADH-peroxidase	gnl\|CDD\|153105	cd01046, Rubrerythrin_like, rubrerythrin-like, diiron-binding domain. Rubrerythrin-like domain, similar to rubrerythrin, a nonheme iron binding domain found in many air-sensitive bacteria and archaea, and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system. The rubrerythrin protein has two domains, a binuclear metal center located within a four-helix bundle of the rubrerythrin domain, and a rubredoxin domain. The Rubrerythrin-like domains in this CD are singular domains (no C-terminus rubredoxin domain) and are phylogenetically distinct from rubrerythrin domains of rubrerythrin-rubredoxin proteins.	9.97843e-59
NC_022571.1\|WP_022743471.1\|1661334_1662573_+\|IS256-family-transposase	gnl\|CDD\|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	4.35168e-124
NC_022571.1\|WP_022744757.1\|1655776_1656952_-\|beta-glucanase-Bgc	gnl\|CDD\|366548	pfam01270, Glyco_hydro_8, Glycosyl hydrolases family 8.	1.17149e-10
NC_022571.1\|WP_041716167.1\|1660108_1661170_+\|iron-containing-alcohol-dehydrogenase-family-protein	gnl\|CDD\|341453	cd08174, G1PDH-like, Glycerol-1-phosphate dehydrogenase-like. These glycerol-1-phosphate dehydrogenase-like proteins have not been characterized. The protein sequences have high similarity with that of glycerol-1-phosphate dehydrogenase (G1PDH) which plays a role in the synthesis of phosphoglycerolipids in Gram-positive bacterial species. It catalyzes the reversibly reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in a NADH-dependent manner. Its activity requires Ni++ ion.	6.77791e-159
NC_022571.1\|WP_022744749.1\|1645675_1647250_+\|ABC-transporter-permease-subunit	gnl\|CDD\|270327	cd13609, PBP2_Opu_like_1, Substrate-binding domain of putative ABC-type osmoprotectant uptake system; the type 2 periplasmic-binding protein fold. This group includes the periplasmic substrate-binding component of a putative ABC transport system that is predicted to be involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. The relative substrate preference of this group is not known. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.17372e-152
NC_022571.1\|WP_140395263.1\|1649464_1650118_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.01342e-92
NC_022571.1\|WP_022744766.1\|1666676_1667207_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	6.68234e-09
NC_022571.1\|WP_022744752.1\|1648756_1649296_+\|nitroreductase-family-protein	gnl\|CDD\|380316	cd02139, nitroreductase, nitroreductase family protein. A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.	1.50517e-72
NC_022571.1\|WP_022744764.1\|1665401_1665542_+\|hypothetical-protein	gnl\|CDD\|182117	PRK09857, PRK09857, recombination-promoting nuclease RpnA.	0.00161274
NC_022571.1\|WP_041716163.1\|1654721_1655519_+\|sel1-repeat-family-protein	gnl\|CDD\|223861	COG0790, COG0790, FOG: TPR repeat, SEL1 subfamily [General function prediction only].	2.23265e-43
NC_022571.1\|WP_022744768.1\|1668207_1669611_+\|L,D-transpeptidase/peptidoglycan-binding-protein	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	8.71052e-25
NC_022571.1\|WP_022744755.1\|1651837_1654186_+\|bifunctional-glutamate--cysteine-ligase-GshA/glutathione-synthetase-GshB	gnl\|CDD\|179427	PRK02471, PRK02471, bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB.	0
NC_022571.1\|WP_022744754.1\|1650335_1651409_+\|transglutaminase	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	2.00105e-13
NC_022571.1\|WP_022744762.1\|1662775_1664650_-\|anaerobic-carbon-monoxide-dehydrogenase-catalytic-subunit	gnl\|CDD\|130763	TIGR01702, Carbon_monoxide_dehydrogenase, carbon-monoxide dehydrogenase, catalytic subunit. This model represents the carbon-monoxide dehydrogenase catalytic subunit. This protein is related to prismane (also called hybrid cluster protein), a complex whose activity is not yet fully described; the two share similar sets of ligands to unusual metal-containing clusters.	0
NC_022571.1\|WP_022744763.1\|1664766_1665180_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	9.31722e-37

>NC_022571.1|WP_022744758.1|1657284_1658418_+|hypothetical-protein
MKTKVCKICVFFIACFSIFLINGIQAKAADLTPDYGIYWYGKGNVSEKFVPGQSNRYFDPTKPTIIYVHGWQKDSQPNNKRESFNFKDENGNVVNGADAWIDKGWNIGIFYWDMFSDEFSVTDAEAKIWSNNGPQKMRWRDHSGNYHYSDYKNAGELFYDTYVQAMKNYKGNNIRIAGHSLGNQMATYLTKRVYDAADAGQISKNLKPSRLALLDPYWSNGGKSYLNNKWTGEACREYVKDLKSKGTAIELYRSTYIDETPAGDNNKGELDQTAFVHLNAWFKNSFDIAGKHNAAVSIYFTSYSSPAPALYNRDGYKKYSKIAGNGPSAASSDSEIKNFMNSNYRYDQYTGVYTLSSKDNGFAQMDRNTNVYVVPIN
>NC_022571.1|WP_022744757.1|1655776_1656952_-|beta-glucanase-Bgc
MVITFYNHLLINYYSQTNLNSSLLSFYNDWKFRYLRSIKGSYPLKEYLLYTLDQPTANNAITTSEAMGYGMIIFPIMSKFDPTAKVHFTALYNYMKSYPSIYNNNLMAWQQIKDSNGNIVNSEPEPSSATDGDMTISYGLILAYKLWGENDTINYKAEAIKRINTLMNSCVNKNDYILTLGDWVKAIPYNNFKYVTRSSDFMSYYIRKFIEFDINNSTEWKLVLKRFHSIISKQMRRESKYNGLMPDFFIKHNDEYIAPTFKVLESIHDGDYYYNSCRIPWRYSMDILLNKVPVTLQLHTLNNWIKRETLSNPKNIKSGYYIANGFPGEPFGHTDDLSFIAPFLISSLIEKGNDNWTISLWETLLNKPITKCTFYENTLKLISMIVATGGY
>NC_022571.1|WP_041716163.1|1654721_1655519_+|sel1-repeat-family-protein
MSGVLVYMDKIVESYQEADINFENMELKKLKKYALRGNLRAQNTIGDRYYIGDGVEKNYEEAFRWYKKAADEGYNVAQYNLGDMYYCGFGIEKNYIKAIELFKKAANKGNIEAACNLGCMYEEGDGTKTDYEEAIKWYVKASEQDDFYAQYNLGNMYMYGKGVAQNYQKAFQLHEKSAKQGYMKAQNTLGYLYEEGKGTLRSYENALKWYEEAAYQEYPYAEYNLGGMYYTGKGVEQNLRIAYAWYERSAEHGLEKAQKALSEKF
>NC_022571.1|WP_022744755.1|1651837_1654186_+|bifunctional-glutamate--cysteine-ligase-GshA/glutathione-synthetase-GshB
MLNKLKKVFTAYELLRGNYGIERESLRVNKDGEISLNSHPTVFGDKIKNPSITTDFSESQIEVITPPFKKVEEVFSFTNALYDIVSMEIGDEYLWPQSMPSIVPEDSKIPIAEYEDDNQGKDARIYREKLIKKYGGKKQLICGIHYNFSFSEEFIEKLYRNEIFKSEFLHNKCIDQDEKDLEYKTFKNNIYLKVSRNYLRYRWLIIYLMGASGIVHESYKCGCKSSVEEIAKSSFTNEGALSYRNSECGYKNKVDLFPSYNSVEEYVESLKKFINDEVINSHKELYSSVRLKPADVKDFSDSLLKDGIKYLEYRSIDINPFEKGGISLEDLYFLQVFNLFLLIDEESDYERWQEDATENQNIISKFGQKSVMLKKDGKSISKEEWALEILQNIKRINNELNLEKEDIIDTMIKKVNNYKLTYAYRIEKIVKEQGYINAHLNLAKKYKENAYNNRFKLEGYEELELSTQILMKEAIKRGISVEVVDKAENFICLKKDDKVEYVKQATKTSKDNYITILIMENKSVTKKILKDNNIIVPNGIEVNSLYEVSNIIKDFVHKPIVIKPKSTNFGTGISIFSEGADEDSIIQAFKIAFKYDNTVLIEEFIKGKEYRFLVTDDKVAGILCRIPANVKGDGKKTIKELVEIKNQDSLRGYHYVTPLEKINLDENAALFLKQQNKDFNYIPKKDEIVYLRENSNISTGGDSIDYTECIPEKFKEIAVKSARAAGAKICGVDMILENYRDENTNYAIIELNFNPAIHIHCYPFKGTERKIGEDVLRVLGFI
>NC_022571.1|WP_022744754.1|1650335_1651409_+|transglutaminase
MKKIIKGIVVILILMCTGYVQPVFASDQNLDNYIYNHLKNWDTEFEIPYYNDDVIDVVQNIAKKDDYLSRSISQLCYKKEENKATLIVAYRTTKEQEEYIDEELKKVINSIITPNMNDFDKVKTINKYLVDRYEYDYALQSNNVYSALTTGKTTCQGYAMSAYKMLNLAGIENRIVIGTLSGTPHGWNLVKLGGKWYQLDVTNDDAVSIDKYFLKSDDYLKKDGFSWNCSDYPKCDSNYQETLQSNKVNESANNVTSKEDYDLNNNGQTIYTYRSSVDGKWCLVNGFWYFLKNDGDYAIGWKLIDNNWYYLSDNGIMQNGWIYSDSKWYYCYPTTGAMATNTSINGYVVDTNGVWIA
>NC_022571.1|WP_140395263.1|1649464_1650118_+|HAD-IA-family-hydrolase
MKKNFEYILFDLDGTLTDSGEGITKAVQYALKYFGIEVSNLDDLRKFVGPPLKESYKNFYGFDDEKADLGLVKFREYYIEKGIYENKMYSGISEVLEKLQKSNKKIIVATSKPEEHAKIVLNHFKIDKYFDFICGADFKETRVKKGDVIKYALEEAKITDLSKAIMVGDREHDIIGAKENNLKSVGVLYGYGDVVELTQARVDYIAKEPKDLLEILL
>NC_022571.1|WP_022744752.1|1648756_1649296_+|nitroreductase-family-protein
MIEVIKNRRSIRKYMNKEVEEDKLLEILESGRLAPSGSNTQPWQFIVIRPQKNKEKVAKVSHNQKWMTTAPIQIVCVADIRCRIDENIDISLDENSKEEEVKQIIRDTSIAVEHMSLTATELGLGSCWVAWFTQAEFRPVLNIPDDKYVLCVLTIGYPDEVPNPRPRKKLEDIVHYEKW
>NC_022571.1|WP_022744751.1|1647944_1648487_-|NADH-peroxidase
MKKFICTVCGYIHEGDTPPEVCPICKVGADKFKEMKDDLNFADEHRIGIPDNLDDEILEGLRANFIGECTEVGMYLAMSRQADREGYPEVGEAYKRIAFEEAEHAAKFAEILGEVVVPSTKSNLSARVEAEYGACEGKKKLATLAKQNNLDAIHDTVHEMCKDEARHGKAFKGLLDRYFK
>NC_022571.1|WP_022744750.1|1647581_1647908_-|DUF1540-domain-containing-protein
MQKINCEVTNCSHNKSGVCYSNRVDIGGINACSESGTCCGSFLNEAHYGDLTSNTNSNSHSHCDCLICKVESCTHNQNTLCDLNSINVCGSSNSQIYYETECGSFEAK
>NC_022571.1|WP_022744749.1|1645675_1647250_+|ABC-transporter-permease-subunit
MNELFNYLFGAKAQIITLLFEHIRLTALSVGIAILIGMPLGILISYVKKLNKPVLGVASIVQAIPSMALLGFAIPFLGIGTTPAIVMVVLYSLLPIIKNTTTGINGINTQVVEAAKGIGLTRFQILFKIQIPLALPTIMSGIRISAVTAVGLMTMAAFIGGGGLGYLVFSGIRTVNNYQILAGAIPSCILALLVDGIFAIVEMLVTPINLQKNNNKSSLAKIKIRRFQKGILCATACLLMVIFVFTGVSKKINNKKEITIGSKDFTEQEVLGNILSELIERKTDISVNRKFALGGTQVIFSALQRGDVDMYVSYSGTAYGDILKYSPISDVENVYDTVKKDYKDKFNIEVLKQMNFNNTYTLAVTKGTAEKYNLKTISDIAKVGNKLNATTTLEFLNREDGLLGLTNKYNFNFNNTVGIDGTPRYSALMNNESDVIDAFSTDGLLKKYNLTVLKDDKKFFPPYYAIPVVRSEVLEKYPEIKPLVEEAGSLITNDVMIELNYDVDELKKDPKDVAIEFLQKNKLI
>NC_022571.1|WP_022744760.1|1659658_1659970_+|hypothetical-protein
MEKVNDLISKNPIHLTTNTIILIVVAIVAFYIVMKAIEGIVKIIAILGVCYFALMSIQSTNLINVPVIKETYATIEKIIPSKELWTDALNKADKINKVVNDLK
>NC_022571.1|WP_041716167.1|1660108_1661170_+|iron-containing-alcohol-dehydrogenase-family-protein
MKTLIHRIAIPSILEVGKGNINNVGNLIKKSNFKKVLICFGEGIKELFGDSIENSLKEAVIEISKTEIIKDINFEEISIKAFEISNDVEALIGVGGGKAIDAVKYMSFLKKLPFISIPTSTSNDGFSSPGASLLVSGRRMSLPAKTPHGIIIDIDVIKGAPEKFIFSGVGDLISNITALHDWNFEEEHGKIIIDDFAKMISKKSVNSFVRTEFKTIKDDLFLKELVDSLTLNGISMEIAGDSSPASGSEHLISHALDKFLEKPELHGIQVGIATYIMSKVQNHRVERISKVLRETGFFEYVKTLKMRKEDFKKAIDIAPSIKPNRYTYIHVEENRILAKKIIDEDEILNYILV
>NC_022571.1|WP_022743471.1|1661334_1662573_+|IS256-family-transposase
MSKPIDDDFDYKAEVKKCKTIDDVMGKNGLIQRLVKDVLENILEGEMEEHLGRNKYQRAETNDSTKKNYRNGYSTKNLRSSFGDVDLDVPRDRNAEFEPQIIKKYETVCTELDKKVISLYAKGMTTSDIQAEIEDLYGITISPSMVSRITDKVMESAVEWQNRSLDKVYPIVYLDAMYFKVRSNGKIMNKAVYICLGYNMQGYKEILGSWVDEAEGAKFWLKICTDLKNRGVREILIACMDGLKGLPEAIKTVFPSVNIQTCIVHQIRNSVKYIASKDKKEFIKDLKCVYKASTEELALAQLDNLKDKWGDKYAIVIDSWYNNWSHLSTFFTFSPEIRKMIYTTNTLEGFNRQIRKYTKSRTVFPTDESLSKCVYLATMEIIEKWTQPTPNWGRTLAELSIVFEEQLNDELA
>NC_022571.1|WP_022744762.1|1662775_1664650_-|anaerobic-carbon-monoxide-dehydrogenase-catalytic-subunit
MSMCTSADCKLCEFLSSKEEIETSFNRVDTQKAKCKFGKEGVCCKLCSNGPCKITPKSPRGICGADADTIVSRNFLRAIAAGSACYLHVVENTARNLKNIGEGKGNVKIKSPQTLNQLAEIFDITESDINQKAIKVADAVLADLYKPRFEKMELVKKLAYAPRYKRWEELNILPGGAKSEVFDAIVKTSTNLNSDPVDMLFNALGLGVATGIYGLMLTNLLNDVILGVPTIRQARVGFRVIDEDYINIMITGHQHSHISHLQDRLIDEDVKKKAINAGAKGFRLVGCTCVGQDLQLRGEHYTEVFSGHAGNNYTSEAVLATGGIDLIVSEFNCTIPGLEPIAEQFKVKTICIDDVAKKKNAKYINFDMDNAEEISEKIISEALESYKNRRNDITIDIPKDHGYDDVVTGVSEGSLKEFLGGNWKGLIDLIAQGKIKGIAGVVGCSNLTAKGHDVFTVELTKELIKRNILVLSAGCSSGGLENVGLMSPGAAELAGDNLKEVCKALGIPPVLNFGPCLAIGRLEMVATELAENLGIDIPQLPLVLSAPQWLEEQALADAAFGLSLGLPLHVAISPFIDGSPVVTKVLKEDLVDITGGKLIVEDDVIKAADELEKIIANRRAEMNI
>NC_022571.1|WP_022744763.1|1664766_1665180_-|Rrf2-family-transcriptional-regulator
MNINQESDYAFRIILMLSKEGLDNKLDAKSLAEQGNIPLRFLLKLTRKLTQAGIVKSYRGVNGGYAITKEPKDITLKDVVEAIQGPIIVNRCIYDKEACSANKASHCSIHKALCNVQNTLLDELKKVTFEQLKNDPW
>NC_022571.1|WP_022744764.1|1665401_1665542_+|hypothetical-protein
MEKLKKGEHEKAMEKAKSMLDKGCGMGEILEETHLSEENVTKAKRK
>NC_022571.1|WP_022744765.1|1665641_1666397_-|exonuclease-domain-containing-protein
MNYIIYDLEFNQRPSVLTNIDSNNISKLPFEIIQIGALKLNKNLDTISTFNALIKPTLYKTIHPFVEDLTKITTEQVNSCDTFPEVYKNFLNFIGSEEITFCIWGSADIKELIKNIKFHNLSTSSISKKYIDVQNYVSKHFNAPNGTKIGLKNAVELFNIATKTEFHDAFNDAFYTAEVFKKIYNHNIVSKTYESFPSRRLHQPKEKIDTNALIFQFEKMYNRKMTKDEISIIKTAYMMGKTKQFIKNESE
>NC_022571.1|WP_022744766.1|1666676_1667207_+|PadR-family-transcriptional-regulator
MTQIEIILLALLYDKDCHGYEFEQIIEKEKMRMWTHIGFSSIYNALNKLEHCDYIVSRLEKGNGSSSKRVYSIKDESKKIVKENIKKMISEYKSNPNDFKIGFIFSYLLSKDELTEALTKHKESLIERKENLNNEQLNVVRSEERKALFERTIAFLETDILWLDKCIKQNSNINYK
>NC_022571.1|WP_022744767.1|1667266_1667416_-|hypothetical-protein
MNENQNISSHDVAKKMIIEGESLDKIREVTHLRLKDLKRIQKNEINPHF
>NC_022571.1|WP_022744768.1|1668207_1669611_+|L,D-transpeptidase/peptidoglycan-binding-protein
MEGHKSKRSKVALGIIMFLCCLAAIYLGISAYFIKHFYLGSTINSMNVSGKTVEEVNEKMSSEIQNYSLELQEKGDVKEQIKGSDIDVKYSQDGESKIKSLKDNQNPLGWISGVFGKKNNETTELISYDEQLLNKVLNGLPGINSKNVVESKDASFEYGDGGYKIVNEVYGNKIDKEVLKQKVSDAIVKEDTTLDLDSSDCYKKPKYTADSQEVTDAKNTLDKYTNVTITYASGNNKEVVDGSAIHNWLSVDDDMQVAFDEKKVKKYVSTKLGSTFNTFGKTRDFTTTSGSKVKVSGGDYGWLIDSTKETKDLIETIKSGQSTTKEPIYAQKAVSSDKNDIGNTYVEVNFTKQHVWFYKNGSLVTDGPCVSGNVSLKLATPPGTYALNYKEKNATLKGEDYSSPVTYWMPFNGNVGLHDASWRSPNEFGGSTYLTSGSHGCVNLPVELAHKIFDNIEAGTPVVCYNE

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Crispr_ID: NC_022571_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022571_3

2252450-2253591

TypeI-B

Consensus_repeat	Method
GTTGAAGATTAACATTATATGTTTTGAAAT	PILER-CR
GTTGAAGATTAACATTATATGTTTTGAAAT	CRISPRCasFinder
GTTGAAGATTAACATTATATGTTTTGAAAT	CRT

17 spacers

cas5,cas7b,cas8b1,cas6,RT,cas3

The CRISPR arrays of NC_022571_3

>merge|NC_022571|3|2252450-2253591|PILER-CR,CRISPRCasFinder,CRT
GTTGAAGATTAACATTATATGTTTTGAAATAATAGAACTTGCTAAAAGGTTAGGAGTTGCTAAAAGGTTGAAGATTAACATTATATGTTTTGAAATAATTAAGTGATGAAAGAATAGAAGAAAAAGAAGTTGGTTGAAGATTAACATTATATGTTTTGAAATGAAGGTAATGAAAGCATTTCACTCAACTGACTAAAGTTGAAGATTAACATTATATGTTTTGAAATGCTAGTAATGAAGATGATGATGTAGACACTACTAAGTTGAAGATTAACATTATATGTTTTGAAATATAGGTGATAAGGATTATTCTATTTCTAGCAGTTGGGTTGAAGATTAACATTATATGTTTTGAAATTGTTTTCCATCCATTTCGTACTCATTCGAATTTAGTTGAAGATTAACATTATATGTTTTGAAATGAAACTTTTTCTTTTTTATTTTTAGATTTAACGCTGTTGAAGATTAACATTATATGTTTTGAAATAGAAATTTTATACACATAAGTTCATTCACTTCAAATGTTGAAGATTAACATTATATGTTTTGAAATGATTTAATGGAAATTTAGATGAACTTTCTGTATTAGTTGAAGATTAACATTATATGTTTTGAAATACTAGTGAAACTGCCATCAATACTTACATTGAATTCGTTGAAGATTAACATTATATGTTTTGAAATTTAAATAATTATTAGAATTAGATATACTACTAGTTGGTTGAAGATTAACATTATATGTTTTGAAATGCAAATGGAACAGATGTACTTGATGAAGAATATGAGTTGAAGATTAACATTATATGTTTTGAAATGCACATTTATTCAAAACCATTTGTATAGCATTTTTGTCGAAGATTAACATTATATGTTTTGAAATTGACCTACTACGTTTTCATGACTCCCCACCATGATGTTGAAGACTAACATTATATGTTTTGAAATAGTGCTGTAGACATTTCCCCAATTACTAAAAGAATGTTGAAGATTAACATTATATGTTTTGAAATTTGTCTAATTTTTTTATTCCTGGTATTTCAGTTATTGTTGAAGATTAACATTATATGTTTTGAAATAAATTATAAGCATATACAAGTGTATTTGTTTTTCCTGTTGAAGATTAACATTATATGTTTTGAAAT

>NC_022571|3|1|2252450-2253591|PILER-CR
GTTGAAGATTAACATTATATGTTTTGAAAT	AATAGAACTTGCTAAAAGGTTAGGAGTTGCTAAAAG
GTTGAAGATTAACATTATATGTTTTGAAAT	AATTAAGTGATGAAAGAATAGAAGAAAAAGAAGTTG
GTTGAAGATTAACATTATATGTTTTGAAAT	GAAGGTAATGAAAGCATTTCACTCAACTGACTAAA
GTTGAAGATTAACATTATATGTTTTGAAAT	GCTAGTAATGAAGATGATGATGTAGACACTACTAA
GTTGAAGATTAACATTATATGTTTTGAAAT	ATAGGTGATAAGGATTATTCTATTTCTAGCAGTTGG
GTTGAAGATTAACATTATATGTTTTGAAAT	TGTTTTCCATCCATTTCGTACTCATTCGAATTTA
GTTGAAGATTAACATTATATGTTTTGAAAT	GAAACTTTTTCTTTTTTATTTTTAGATTTAACGCT
GTTGAAGATTAACATTATATGTTTTGAAAT	AGAAATTTTATACACATAAGTTCATTCACTTCAAAT
GTTGAAGATTAACATTATATGTTTTGAAAT	GATTTAATGGAAATTTAGATGAACTTTCTGTATTA
GTTGAAGATTAACATTATATGTTTTGAAAT	ACTAGTGAAACTGCCATCAATACTTACATTGAATTC
GTTGAAGATTAACATTATATGTTTTGAAAT	TTAAATAATTATTAGAATTAGATATACTACTAGTTG
GTTGAAGATTAACATTATATGTTTTGAAAT	GCAAATGGAACAGATGTACTTGATGAAGAATATGA
GTTGAAGATTAACATTATATGTTTTGAAAT	GCACATTTATTCAAAACCATTTGTATAGCATTTTT
GTCGAAGATTAACATTATATGTTTTGAAAT	TGACCTACTACGTTTTCATGACTCCCCACCATGAT
GTTGAAGACTAACATTATATGTTTTGAAAT	AGTGCTGTAGACATTTCCCCAATTACTAAAAGAAT
GTTGAAGATTAACATTATATGTTTTGAAAT	TTGTCTAATTTTTTTATTCCTGGTATTTCAGTTATT
GTTGAAGATTAACATTATATGTTTTGAAAT	AAATTATAAGCATATACAAGTGTATTTGTTTTTCCT
GTTGAAGATTAACATTATATGTTTTGAAAT

>NC_022571|3|3|2252450-2253591|CRISPRCasFinder
GTTGAAGATTAACATTATATGTTTTGAAAT	AATAGAACTTGCTAAAAGGTTAGGAGTTGCTAAAAG
GTTGAAGATTAACATTATATGTTTTGAAAT	AATTAAGTGATGAAAGAATAGAAGAAAAAGAAGTTG
GTTGAAGATTAACATTATATGTTTTGAAAT	GAAGGTAATGAAAGCATTTCACTCAACTGACTAAA
GTTGAAGATTAACATTATATGTTTTGAAAT	GCTAGTAATGAAGATGATGATGTAGACACTACTAA
GTTGAAGATTAACATTATATGTTTTGAAAT	ATAGGTGATAAGGATTATTCTATTTCTAGCAGTTGG
GTTGAAGATTAACATTATATGTTTTGAAAT	TGTTTTCCATCCATTTCGTACTCATTCGAATTTA
GTTGAAGATTAACATTATATGTTTTGAAAT	GAAACTTTTTCTTTTTTATTTTTAGATTTAACGCT
GTTGAAGATTAACATTATATGTTTTGAAAT	AGAAATTTTATACACATAAGTTCATTCACTTCAAAT
GTTGAAGATTAACATTATATGTTTTGAAAT	GATTTAATGGAAATTTAGATGAACTTTCTGTATTA
GTTGAAGATTAACATTATATGTTTTGAAAT	ACTAGTGAAACTGCCATCAATACTTACATTGAATTC
GTTGAAGATTAACATTATATGTTTTGAAAT	TTAAATAATTATTAGAATTAGATATACTACTAGTTG
GTTGAAGATTAACATTATATGTTTTGAAAT	GCAAATGGAACAGATGTACTTGATGAAGAATATGA
GTTGAAGATTAACATTATATGTTTTGAAAT	GCACATTTATTCAAAACCATTTGTATAGCATTTTT
GTCGAAGATTAACATTATATGTTTTGAAAT	TGACCTACTACGTTTTCATGACTCCCCACCATGAT
GTTGAAGACTAACATTATATGTTTTGAAAT	AGTGCTGTAGACATTTCCCCAATTACTAAAAGAAT
GTTGAAGATTAACATTATATGTTTTGAAAT	TTGTCTAATTTTTTTATTCCTGGTATTTCAGTTATT
GTTGAAGATTAACATTATATGTTTTGAAAT	AAATTATAAGCATATACAAGTGTATTTGTTTTTCCT
GTTGAAGATTAACATTATATGTTTTGAAAT

>NC_022571|3|1|2252450-2253591|CRT
GTTGAAGATTAACATTATATGTTTTGAAAT	AATAGAACTTGCTAAAAGGTTAGGAGTTGCTAAAAG
GTTGAAGATTAACATTATATGTTTTGAAAT	AATTAAGTGATGAAAGAATAGAAGAAAAAGAAGTTG
GTTGAAGATTAACATTATATGTTTTGAAAT	GAAGGTAATGAAAGCATTTCACTCAACTGACTAAA
GTTGAAGATTAACATTATATGTTTTGAAAT	GCTAGTAATGAAGATGATGATGTAGACACTACTAA
GTTGAAGATTAACATTATATGTTTTGAAAT	ATAGGTGATAAGGATTATTCTATTTCTAGCAGTTGG
GTTGAAGATTAACATTATATGTTTTGAAAT	TGTTTTCCATCCATTTCGTACTCATTCGAATTTA
GTTGAAGATTAACATTATATGTTTTGAAAT	GAAACTTTTTCTTTTTTATTTTTAGATTTAACGCT
GTTGAAGATTAACATTATATGTTTTGAAAT	AGAAATTTTATACACATAAGTTCATTCACTTCAAAT
GTTGAAGATTAACATTATATGTTTTGAAAT	GATTTAATGGAAATTTAGATGAACTTTCTGTATTA
GTTGAAGATTAACATTATATGTTTTGAAAT	ACTAGTGAAACTGCCATCAATACTTACATTGAATTC
GTTGAAGATTAACATTATATGTTTTGAAAT	TTAAATAATTATTAGAATTAGATATACTACTAGTTG
GTTGAAGATTAACATTATATGTTTTGAAAT	GCAAATGGAACAGATGTACTTGATGAAGAATATGA
GTTGAAGATTAACATTATATGTTTTGAAAT	GCACATTTATTCAAAACCATTTGTATAGCATTTTT
GTCGAAGATTAACATTATATGTTTTGAAAT	TGACCTACTACGTTTTCATGACTCCCCACCATGAT
GTTGAAGACTAACATTATATGTTTTGAAAT	AGTGCTGTAGACATTTCCCCAATTACTAAAAGAAT
GTTGAAGATTAACATTATATGTTTTGAAAT	TTGTCTAATTTTTTTATTCCTGGTATTTCAGTTATT
GTTGAAGATTAACATTATATGTTTTGAAAT	AAATTATAAGCATATACAAGTGTATTTGTTTTTCCT
GTTGAAGATTAACATTATATGTTTTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022571.1\|WP_022745989.1\|2248711_2250490_+\|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl\|CDD\|188234
NC_022571.1\|WP_022745966.1\|2239880_2241689_+\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_064530724.1\|2260103_2260664_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NC_022571.1\|WP_052334828.1\|2245572_2246565_+\|DUF4179-domain-containing-protein	unknown	unknown	gnl\|CDD\|379369
NC_022571.1\|WP_022745975.1\|2245022_2245550_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|213752
NC_022571.1\|WP_022745994.1\|2253643_2256220_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224124
NC_022571.1\|WP_022746007.1\|2261521_2262883_+\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240548
NC_022571.1\|WP_022746013.1\|2264284_2266336_+\|chemotaxis-protein-CheA	unknown	unknown	gnl\|CDD\|223716
NC_022571.1\|WP_022745986.1\|2248001_2248697_+\|hypothetical-protein	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_022571.1\|WP_022745999.1\|2258143_2258728_+\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NC_022571.1\|WP_022746010.1\|2263458_2264265_+\|chemotaxis-protein-CheR	unknown	unknown	gnl\|CDD\|214534
NC_022571.1\|WP_022745997.1\|2257502_2258051_+\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022745972.1\|2243778_2244804_+\|DUF1835-domain-containing-protein	unknown	unknown	gnl\|CDD\|378848
NC_022571.1\|WP_022746016.1\|2266370_2267417_+\|chemotaxis-response-regulator-protein-glutamate-methylesterase	unknown	unknown	gnl\|CDD\|234828
NC_022571.1\|WP_022745996.1\|2256380_2257217_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_022571.1\|WP_022746004.1\|2260999_2261437_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_022571.1\|WP_022745991.1\|2250482_2251466_+\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_022571.1\|WP_022745983.1\|2246847_2247633_+\|glycoside-hydrolase-family-11-protein	unknown	unknown	gnl\|CDD\|366111
NC_022571.1\|WP_022745969.1\|2241685_2243191_+\|RNA-directed-DNA-polymerase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|239569
NC_022571.1\|WP_022745992.1\|2251468_2252251_+\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641

Protein	Function_ID	Function_description	E-value
NC_022571.1\|WP_022745989.1\|2248711_2250490_+\|hypothetical-protein	gnl\|CDD\|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	6.59656e-06
NC_022571.1\|WP_064530724.1\|2260103_2260664_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.71489e-09
NC_022571.1\|WP_052334828.1\|2245572_2246565_+\|DUF4179-domain-containing-protein	gnl\|CDD\|379369	pfam13786, DUF4179, Domain of unknown function (DUF4179).	2.99941e-10
NC_022571.1\|WP_022745975.1\|2245022_2245550_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|213752	TIGR02954, RNA_polymerase_ECF-type_sigma_factor, RNA polymerase sigma-70 factor, TIGR02954 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is found in certain Bacillus and Clostridium species.	3.51867e-37
NC_022571.1\|WP_022745994.1\|2253643_2256220_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.75461e-29
NC_022571.1\|WP_022746007.1\|2261521_2262883_+\|MATE-family-efflux-transporter	gnl\|CDD\|240548	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.	1.4831e-97
NC_022571.1\|WP_022746013.1\|2264284_2266336_+\|chemotaxis-protein-CheA	gnl\|CDD\|223716	COG0643, CheA, Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms].	2.04829e-150
NC_022571.1\|WP_022745986.1\|2248001_2248697_+\|hypothetical-protein	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	1.4086e-09
NC_022571.1\|WP_022745999.1\|2258143_2258728_+\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	2.45656e-55
NC_022571.1\|WP_022746010.1\|2263458_2264265_+\|chemotaxis-protein-CheR	gnl\|CDD\|214534	smart00138, MeTrc, Methyltransferase, chemotaxis proteins. Methylates methyl-accepting chemotaxis proteins to form gamma-glutamyl methyl ester residues.	1.00269e-85
NC_022571.1\|WP_022745972.1\|2243778_2244804_+\|DUF1835-domain-containing-protein	gnl\|CDD\|378848	pfam12395, DUF3658, Protein of unknown function. This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with pfam08874. There are two completely conserved residues (D and R) that may be functionally important.	1.07103e-39
NC_022571.1\|WP_022746016.1\|2266370_2267417_+\|chemotaxis-response-regulator-protein-glutamate-methylesterase	gnl\|CDD\|234828	PRK00742, PRK00742, chemotaxis-specific protein-glutamate methyltransferase CheB.	5.48405e-168
NC_022571.1\|WP_022745996.1\|2256380_2257217_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.25284e-22
NC_022571.1\|WP_022746004.1\|2260999_2261437_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.08728e-16
NC_022571.1\|WP_022745991.1\|2250482_2251466_+\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	6.11559e-37
NC_022571.1\|WP_022745983.1\|2246847_2247633_+\|glycoside-hydrolase-family-11-protein	gnl\|CDD\|366111	pfam00457, Glyco_hydro_11, Glycosyl hydrolases family 11.	4.77448e-86
NC_022571.1\|WP_022745969.1\|2241685_2243191_+\|RNA-directed-DNA-polymerase	gnl\|CDD\|239569	cd03487, RT_Bac_retron_II, RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA branches out from a small ssRNA molecule via a 2'-5'phosphodiester linkage. Bacterial retron RTs produce cDNA corresponding to only a small portion of the retron genome.	2.32383e-80
NC_022571.1\|WP_022745992.1\|2251468_2252251_+\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.35433e-49

>NC_022571.1|WP_022745992.1|2251468_2252251_+|type-I-B-CRISPR-associated-protein-Cas5
MDVVKINIYGKTAFFKKPEVNTYRYLTYGQLHKVALMGIFGCILGLNGYGQQGDKVYPEFYEKLKDIKVSIVPISPAKTGGFSKKIQQFNNSVGYASKEEGGNLIVTEQWLENVSWEVYILCNNDISNKLKDALLGKNTVYIPYLGKNDHVANISSIEVYKGVETQDVSYISTLDSLFLKDCVNIKKLIKPNGFRPVKAAPSCGLEKMREYVYQEFLPYALEPKFNTYDTRKFICTNKSIEVNDKESIIYSINDKNLFFY
>NC_022571.1|WP_022745991.1|2250482_2251466_+|type-I-CRISPR-associated-protein-Cas7
MSNNIKNKLERVYGVLGIKSTMANWNADFTGYPKSLGDGTVYGSDKAYKYPMKVMWDSDPIKRVMYIKSYKVLEKGNDKLLQPRSLKERYEEIYGIEDLKKENDNITVLKNLFQAIDVKNFGATFAESGNNLSIIGAVQITQGLNKYDGHVADYEQILSPFRDGSEKPLKKGEEAKEVMQSTLGNKIFSNEAHYFYSFSINPSVYDKFVKLGVTDGYTREDYEEFKKTALIAASAYDTNAKSGCENEFGLFVETDGDLFLSDLAQYVTFSKSQEGKEVINLVELSKLLNDCMDRIQSVEIYYNPYTTVLEGDIAKARYINIFTRKDV
>NC_022571.1|WP_022745989.1|2248711_2250490_+|hypothetical-protein
MLDDCLDIFEREYKITGDSIILDKYTPDSGLYLLVDSFGDVIKTAEIDNRGTNRHLYKDFIEIDYLSRLLEMNKPIDNKKTVKSNNYLSFWVKITDLMEDTKTKKIKVDEECIDRYFDTLASIDKKYKDKNSTKLYQTILKDVGDIDLKKLENCRAWIKKNIFNILNNYSVDKKYKYVKVFFKADIELYKSEANRYIYPNLFNSNDYNEYEDGLIYGLPNNNMGMNSKKPYLKRIDRNIKVPFLVSLERAMIMKKFFDYLSCLVDGEDKRLNLYIGDSNGLDPIADSALKDSNFNGIYLRLAKEKNEVEIVDYDVISNYTPILKDFFIKEIISSAKTKIKENDNSLVYKEVTKLDELRTIISNIFFNKFLATNFFTPAKNIRLADMVIKDELIKTRAAYFNWFYKNDKNRIINDFEDSSLRLIKNSVVNGYESRAREQFNLRNCINVYLKGSVVDMSNVVLKSYEELSRKLLCKEFISCETDAEYYFAIGQISYYLLYQSNSSKRNMSEIDFIINCKKNETLIQRLERLFKKYSHNIPANANKFRQLYSIINAYTPINEQVDDKMVLAGYLFSNVLFIKSSNNQNLEVSVDE
>NC_022571.1|WP_022745986.1|2248001_2248697_+|hypothetical-protein
MIKVYELIVKTYCLKSISDSKALEKISSLIDKAFLNSEDMCKYHNSREYKFYSHDTFDPWTPSGVSVGEIRSFKIRTVDSKLKNYLMTNLLELSTDSLLVLYVTDKVIPKGELSQIESVTPIIIKTEVGYWRNNYDDEFFIDRITANLIKKYNAFTGKNIPLADIELFNKITLKKSHIKRRYKNITLFGDRYVFYLKDDELSQDIGYFALGSGVAEMCPRGFAFMQYQYKK
>NC_022571.1|WP_022745983.1|2246847_2247633_+|glycoside-hydrolase-family-11-protein
MLRRKVIFTVLATLVMTSLTIVDNTAFAATNLNTTESTFSKEVLSTQKTYSAFNTQAAPKTITSNEIGVNGGYDYELWKDYGNTSMTLKNGGAFSCQWSNIGNALFRKGKKFNDTQTYKQLGNISVNYDCNYQPYGNSYLCVYGWTSSPLVEYYIVDSWGSWRPPGGTSKGTITVDGGIYDIYETTRINQPSIQGNTTFKQYWSVRRTKRTSGTISVSKHFAAWESKGMPLGKMHETAFNIEGYQSSGKADVNSMSINIGK
>NC_022571.1|WP_052334828.1|2245572_2246565_+|DUF4179-domain-containing-protein
MINEEKEIPSVVRISLDSTYDRIRAMPKKKNRVVGKIAAAVCCVVILGSMVTNESVRAGIKTFFDFNDKGVEKAINEGWISENSSSACDNGVEVTLDSYFADCNKIGLSIMLKFNDSKILKGIDKVSLDYRIKNGDGEYIEEFIPDTKPLKGKKQYISNVNDRNSKIDLENNEVQYDVILESEEGAIPKLENAVVEVESIKFFKNNKKVKDIDGIWNLKLNGGKSNDINAVEYKAVNNTSKIEIISAKSSPTSFNITFSVDGECINEKEFMPKDIKLVDGNGKEYQSNGYSSELKNNKTIISTNFSLSSYEDFDKLKLVVPSMGEAELEK
>NC_022571.1|WP_022745975.1|2245022_2245550_+|sigma-70-family-RNA-polymerase-sigma-factor
MEINNLVKKAKRGDGEAFISIIKQYEQVLYKVASRMLSNDQDIADALQETIMLGYEKIHTLKNEAYFNTWICRILINKCNCILNKNKNVILVGEILPQKLNNNDFIKIELEDALNSLNKDYKLAMSLYYVVGLSTKEISKLVNEPEGTIKSRLSRAKTILRESYFKNQGGNEYGR
>NC_022571.1|WP_022745972.1|2243778_2244804_+|DUF1835-domain-containing-protein
MSNIIHICFSQSAGGNLKHAIKKKKLFEGKKIIVFPDDISIGKIGNDMNLDERLEWWDIINKEEATIHSEEINYLKRSYKKFYKEISNINDADIIYLWYGECSNDMCGMMNTLELLKDKIDNIYFVNVSEKIYANDNIIYAYKSVSEIITEKLKEFIPIKRKIGHQEYHDLVSQWNLLKKDNSILRIFKDGKVQSLSEDYFDICILKHTENEFRKSARTVGRVIAYSEMKISDEYIFWRIGELTKSGMLEYKGKFGIMREMEIKITQKGIEYMSTDPEAISFWKNRETEEQFEREKINEAKKQGRMEEKIDIAKKLMDILDVEVIAEKTGLTAMQVKNLIN
>NC_022571.1|WP_022745969.1|2241685_2243191_+|RNA-directed-DNA-polymerase
MIESQENSKNNRQEYRKQVDELGKKEFTLIKMQEYGFWPKNLPTPYEKQENETKEQYLERKNLTKEYEKIIKAITDLYDEKDEINAKLRDLNKKYNETWDYEKIRQDVSKAIMEESIARRKERKEKRELEKKQKNEAWQKEKADRIVFIGRGYSGLLYDKENNEEKLLNQGLPVIKDDKALADFLGIEYKKLRFLVYHRDVVLVDHYNRYTIPKKKGGERNIAAPKLILKNVQRKILEEILSKIQVSDYTHGFLKGKSVVSGAKSHIADKASGENTALLINMDLEDFFPTITFERVRGMFKAFGYSGYISSLLAMLCTYCERMPIEVKGKVKYVKTSDKILPQGSPASPMITNIICVKLDKRLSGLSSKYNCVYTRYADDMSFSFMEEGSALNLGKFMGFISKIVNEEGFNINKNKTRFLRKNNRQSITGVVINNDEIGVSKKWIKTLRAAIYNANKLKNSGEKISQKTINEISGMISWIRSVNEKRYANIIESGMNLINT
>NC_022571.1|WP_022745966.1|2239880_2241689_+|hypothetical-protein
MKVDYSYASPSMCLSQGTDTVLGLSPDLSRDEKVSFLGKLKHPLIFRDAMLMLREIVVSDTSNKKKERVEFFEWLDGEIERQILRHEKYLPDVREKLNKDMNELLNKLDEKSMEISKLVDIKNNLKKEIDNHDIWKDYYKLERDFWKFIRDRDYSLWYVLDPVITVHPDQVSFEAFSLDESTYGCLSINMEEFELLQKPVLGTTNIDFSAKLAKEIERFRTYNDVKLSVNPEGFTVDTGVIPEHMEKKIDLPETWIKGFNQVSSAASLGGMDIELSPVDIYDICAFLRRHKAQKSPRYMKWILEPEKPVRIVFEPFGSEITLKAVYNGEKYREEKIWGRRRWLVVEKIIPLAKSFKVRLLGFGMPQFIIADMGTMKMTIGFSSWSSNDWVKGTAFNILGGFIGDGNYDKVYELMKEKRCLSMESIYDNLKDDLRAVSKSGIGMLLKRGESYFDPINDTIRFRKLCNTPIPKELYETTEMEYSVKDHMKESMDNFSVRFTSSNEFIFKHCFKIPNSKYKSWKYHGTEDYNREHDLSETELIIDEDGQICKVKCKCREFNKGPRNISAPCEHILALYLISSKFTRLKLEVDKEYKINDIMEKIL
>NC_022571.1|WP_022745994.1|2253643_2256220_+|CRISPR-associated-helicase/endonuclease-Cas3
MYFENIKIIDISTLLKEPSDIYSHTKSDILEYETLAEHNERCIKYFYKIVDVKNLDSVFNNFEQRLLKGCSSKCINLWKEIVLNTVFFHDVGKSNPGFQKEKMKNEKYKNIKVNNSNHSRASGIVFFNHYYNEVFAVNNDEAKVLFVFLCLSMYVINKHHSSLEDLAKNLQSINKDLKTPEKNMFANIIKDLNNFDEISDINELHYAFRHELESNTEWISLDMYIYTRFLYSLLVASDFYATSEYMTGAKIEHFGIIDDTKDYRTCLDNSAVGKCIGKYKDFKSGLCTNPYGICKGDMLNQLRTEIYLEADFNIDNNINADIFFLPAPTGAGKTNISINLALKLIENNPLLNKISYNFPFNNLVEQTKNSLYETFNENKKIKESISVINSITPIKEFSSTNDNDEVDFNKSLLSRQFLHYPVIVSTHVGLFDILFGINKENLFPLVHLCNSVIILDEIQAYKNSIWKEIIIFLKTYAKLLNIKFIIMSATLPDLTKLCNTNDGFISLIEDNSKYFTNPLFKDRVDIDYKMLNIDKENLFKALILKVIEVSKLLKKQADKFDNKILVEFITKSAAKDFYENLSTKVKDIHSNEEIILFTGDDSSIERKKIINHIKSSKNIILISTQVIEAGVDIDMDIGFKDISMLDSDEQFVGRINRNCKKENCKVYFFNYDDVTKIYKNDIRNSADYSLLSTKMRELFELKKFDIYYDYIINELNEAADSKNAKNIDFFRKNTLTDLEFYNIKKRMKLIDDQSKITIFLNINVEDENGNIFIGENVWNKYLSLLKNFDITYQEKQVELSKIREKVQYFTYEINDKYKGKFSYDIDKSIGNTFYINNGDDYITNGKFDRDKLINDLFS
>NC_022571.1|WP_022745996.1|2256380_2257217_+|AraC-family-transcriptional-regulator
MIIKKSLINKSIEYILQHIDEDISIEDVTNHCNFSKYYFSRMFKEETGSSIYSFIKRVKMDQSVVSLKVEKDKTITEIGVDYGYSSSNYSSAFSKQYSICPVEFRKTMNSTEVANPFYPNEYNTFKSFEHYDAKIIIQDLGNFKVIYERYIGNYNEIGSNWYSFMERYKTYIKLDTLLIEKSYDDPSITQLDKCICDLCITVDEHVELENVTMIKGGKFAVYQFDGSIYDIFVTFLGIFNIWLPRSGYKRDKRYVLGIYRNIDRKNNHVTMDLCIPIK
>NC_022571.1|WP_022745997.1|2257502_2258051_+|hypothetical-protein
MFDIRKIQEHVIYEAVKDERNEDIAREVVYGKDESCKSENNGIWVKSTMKRLESKFDKETTKKIRMKCQCGYGMDKKLELVKELMELSSSLEELGNLQKAKDSGLFYENGDLYLQFNFCPCPMLTNVDKLDSYAWCQCTTGYSKVLFEKAFQCKVDVELLKSIKVGDERCLMKIVPQGIIWK
>NC_022571.1|WP_022745999.1|2258143_2258728_+|flavodoxin-family-protein
MKVIGINGSARKNGNTSIIIKSIFMELEKKGIETELIQLADKTVKGCMGCFGCKGRKQCVIKDDFFNDCFDKMVNADGIILGSPVYSADITSKMKAFLERAGVVVATNPGMLKHKVGASVAAVRRGGGMTAVDILNHFLLNKEVFVVGSTYWNMVYGKDIGDVINDGEGMRNMKNLGENMAWLMEKLSRAHENK
>NC_022571.1|WP_064530724.1|2260103_2260664_+|TetR/AcrR-family-transcriptional-regulator
MDLRVLKTRENIKNTFSNLLLEKDFKNITVQDICDRALIGRSTFYDHYCDKYDLLNKMVEEIINQFKPYLKSRFNLNSLDDFTKLGSDMLKLFSKKKNIIKALINVHTESADLYYELKKLLIEGCSYYLNKSNFVSKYNISNEYICGHYASFVLTSFQLWLELGEDENNLQLANRMHSVLFESAGI
>NC_022571.1|WP_022746004.1|2260999_2261437_+|MarR-family-transcriptional-regulator
MTKSRYSIETPYSQLIRSIAIKMKLSSDEKVKKLGLNSQQGRMIGYIYEHQDSGIIQKDLARVFQRTEASITSMLQGLEKKGYIERRIPKENERQKYIYVLPKGAELIEDFNKLVVEEEENIIANLTEQEKETLLAVLLKVDRNL
>NC_022571.1|WP_022746007.1|2261521_2262883_+|MATE-family-efflux-transporter
MKQKLSNKYYLESAPITKAIAHLSIPMMIGMSVGTIYNVINAFFIGLLNNTDMLTAITLGLPIFTILMAFGNMLGAGGGTFITRLVAKQNIEKAKKIAGYTFYSSIIIGILLGIIAMIALNPIVNIMGADTSAIINYTKSYSLTMFIGGFAIVMNFALEQVVRAEGASKESMFGMVVSTIFSLIFDTLFILVFKFNVVGVALSMILANIASSIYYVYYLETKSENLKGFIKNFNISLKDKIEIYKIGVSELFLAGFLIITTLLLNNYSIRYGEGVVASFGIALRIVQVPEFLAMGLALGIIPLIAYNFSNENFKRLEDSIKQSALWILGLSGGVVTLVYIFRNVIIHLFSNDSAVLSVGVYIMAAMLISAFFNGFTTLFTGIFQASGQGLPSTIMAITQGILFIPVIIVLNNFFGLHGVIWSMTITEIITFLTGVILYIIFNNKIKKNKVVAN
>NC_022571.1|WP_022746010.1|2263458_2264265_+|chemotaxis-protein-CheR
MDEFTDIYFKKYCDLLYKRTGIFVRENKKETFKLKIEKSMRKLNIYNHDEYLQYLQKYDCKEHFQQFINDMTTNTTEFFREKQHFDFIENNIQFIMKNNPRIARKNEIRIWSAASSSGQEAVSLAILLKECLDNRINIKILATDIDSEILSKAVKGIYSHSECKDIPQELLYKYFDKVSNGFSIKGEIRSMIQYRHFNLMQDYNFKKGFDIIFCRNVMIYFSNPIQERLINKFYNNIVQGGLLFIGHSESLVSKSHKYQYIGPAIYMK
>NC_022571.1|WP_022746013.1|2264284_2266336_+|chemotaxis-protein-CheA
MNEILVGYIEDLKYNLINLNEALMEMENGNTNDNVINTVFRVAHTIKGNSAAMEFYNIEKVTHKMEDILQEVRSGKRILTGEIINSLYSFHDFMEDCITFINQDKCDKNIVITEIIQELLKILTGNAPDINESSESNKKHDEELRILKEVKCDTELCNKILENFNRGFMPYWIDVTINERCVMKSLRTWLVFETASAYGSIISSIPECPTEEELGSNKEFIIQNNCVRFLIVIDKDVDLLVSELFNTSEITNVKKQEIDIESIRQKIEDSKKENKIVKDKNIGSSKSQNLKQSSGNEKMADNFIRIPVLKVDGLMDMLGELLILNSQFEQQISEAFGRNSAMMNNLSRSSKLIKEIQASSMSLRMIEIKPTLHRLHRVARDTAAELNKKIFIIIEGEETEIDRSAAEKIFDPLMHLVRNAVSHGIEEEEERIKAGKKAEGTIHIKAYSKRDSVYVEISDDGKGIDTQKILKKALNLNMAEENKVYSEEEIVKFIFKPGFSTQEVVNNISGRGVGMNVVEEVISNLGGKIEVVNVLGQGCAFTIKIPMNLAVMNGTIIEVAGGRYIIPTLFIKEFFIVDKSNLISMQNKTQALRIRNNIIPIVNVSNMFNISENDKLLNLREVVILEMDQRLLAFPVDGIVARQEIVSKPLESEFSSISYASGAAILGDGRVSLILDVEEIFKM
>NC_022571.1|WP_022746016.1|2266370_2267417_+|chemotaxis-response-regulator-protein-glutamate-methylesterase
MEKIKVLVVDDSAMVRKILSSELSKTKEIQVIDTAPDPYIARDKIVKLKPDIVLLDIEMPRMDGLTFLRKLMKYYPIRVIIVSSVAENGSETALKSLEYGALEVVAKPSVSYSVNDMIEQLIEKILAVSKIPNWKVGIKENKKEVDSYSQKKKLSLIKTTNKIIAIGASTGGTEALREILQKMPPSAPPIIIVQHMPQHFTKSFAQRLNQICAIEVKEAEDKEILSPGKALIAPGNMHMELRRSGAVYYVQLHNGPMVYHQRPSVDILFNSVAKYAGRNAIGVILTGMGKDGAAGLLNMKNEGAYTIAQDEKSCVVFGMPKEAIEMGAANKIVSLNYIVDDIIEYLGT

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Crispr_ID: NC_022571_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022571_4

2818090-2820274

TypeI-B

II-B

Consensus_repeat	Method
NNNNNNATTTAAATACATCTCATGTTAATGTTAATC	CRT
ATTTAAATACATCTCATGTTAATGTTAATC	PILER-CR
ATTTAAATACATCTCATGTTAATGTTAATC	CRISPRCasFinder

33 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

The CRISPR arrays of NC_022571_4

>merge|NC_022571|4|2818090-2820274|CRT,PILER-CR,CRISPRCasFinder
CAATTGGTTTCATCATAGTTAATGTTAGTCTTTAAATTATACAAAGCACAAGTATGTTTTAGATAAATTTAAATACATGTCATGTTAATGTTAATCCTACACTTACTCTGTAGCTACCCCATGGCTTACTATTTAAATACATCTCATGTTAATGTTAATCATTTCTTCCTTTTCTGTTTGCTATATTGGCTAATTTATTTAAATACATCTCATGTTAATGTTAATCACTTTGAGCCAGTTATAGATAAGCTTATTAAATAATTTAAATACATCTCATGTTAATGTTAATCAAGATGAATAATGAAAGGTATAGATATTTCAAATAAATTTAAATACATCTCATGTTAATGTTAATCAGGTTAAAGTTATTACCAAAGAGTGTAATTACTGCATTTAAATACATCTCATGTTAATGTTAATCTTAAACCGCCTTTTGGATACATAGGTATCTTATGGTTATTTAAATACATCTCATGTTAATGTTAATCTTTGATTTGTTTTAGTCTTCTTTTTTTTATACAAATTTAAATACATCTCATGTTAATGTTAATCACATAGTTACTTGGGCTTAAGTTATCTATTGTAGATATTTAAATACATCTCATGTTAATGTTAATCTCCAGCTAATGCTAGTGTATTACAAATAGATGGAAATTTAAATACATCTCATGTTAATGTTAATCTTTATTCTTTTTGCTCGTACTAAACTATTATCTACAATTTAAATACATCTCATGTTAATGTTAATCATAGATGGATTTACTCAACTTGGATTCGATGCAAAATTTAAATACATCTCATGTTAATGTTAATCAAAGTATTTAAAATAGAGAGGTGATAAATGATGAGATTTAAATACATCTCATGTTAATGTTAATCAACTATATTAATTTCATCATCTTTTAAATCAATGTAATTTAAATACATCTCATGTTAATGTTAATCCGAAAACTGATAATCCAAGTGACCCTGCTCCTTCATTTAAATACATCTCATGTTAATGTTAATCCTTGTGCAACAGACTTAAACTTAACATTATCAGAAATTTAAATACATCTCATGTTAATGTTAATCCCAACAGTTAATTTTTCCATCTTGACCTTTTATATATTTAAATACATCTCATGTTAATGTTAATCAAGGTAGGCATATTTAAGTAGATTTTAAGAAGCTTTATTTAAATACATCTCATGTTAATGTTAATCTTTTACTGATACAAACACTAAAACTGATACTAAAACATTTAAATACATCTCATGTTAATGTTAATCATAATGGTGGTAAATTCTACATGGTAATTCCTAAATTTAAATACATCTCATGTTAATGTTAATCTATTCCGGAAATGTTGATATTTATTTAAAATTAGCATTTAAATACATCTCATGTTAATGTTAATCGCAAATTTAATTTAAGGAGGAAATTATTATTATGTTATTTAAATACATCTCATGTTAATGTTAATCACTCATGTTACTATATGTTATACAAAAAGTGGTAGATTTAAATACATCTCATGTTAATGTTAATCTAGTAAAAGTGAGGTTGAACATATGATAAAACATAATTTAAATACATCTCATGTTAATGTTAATCTTATGGTTGCTCTGTTAGTGGATTTTCTTTTTCTGTATTTAAATACATCTCATGTTAATGTTAATCATTTAGAAATAGATAAAACTCAAGAGAATAGAATATTTAAATACATCTCATGTTAATGTTAATCGACTCACTTTTGTAAGGTCAGGTAATTCAGTTCGTATTTAAATACATCTCATGTTAATGTTAATCTCATAAAGAAAATAAGAATCGCAAATATTAAAATATCATTTAAATACATCTCATGTTAATGTTAATCACGTAACTATTATTAGAATGAAACGTATTTATACTATTTAAATACATCTCATGTTAATGTTAATCGGTTAATCCTAAATCAATTGCCCATTGTTCCATCAAATTTAAATACATCTCATGTTAATGTTAATCTGACTTGGGTAAAGAACATCAGACTTTAGTTGTTATATTTAAATACATCTCATGTTAATGTTAATCTATCAATCAAATCCTCTTAGTGCATATTTCATCAATTTAAATACATCTCATGTTAATGTTAATCTTCAAGGTATTCTGATTTTACATTTAGTCAGTTGAGATTTAAATACATCTCATGTTAATGTTAATC

>NC_022571|4|2|2818090-2820274|CRT
CAATTGGTTTCATCATAGTTAATGTTAGTC	TTTAAATTATACAAAGCACAAGTATGTTTTAGATAA
ATTTAAATACATGTCATGTTAATGTTAATC	CTACACTTACTCTGTAGCTACCCCATGGCTTACT
ATTTAAATACATCTCATGTTAATGTTAATC	ATTTCTTCCTTTTCTGTTTGCTATATTGGCTAATTT
ATTTAAATACATCTCATGTTAATGTTAATC	ACTTTGAGCCAGTTATAGATAAGCTTATTAAATA
ATTTAAATACATCTCATGTTAATGTTAATC	AAGATGAATAATGAAAGGTATAGATATTTCAAATAA
ATTTAAATACATCTCATGTTAATGTTAATC	AGGTTAAAGTTATTACCAAAGAGTGTAATTACTGC
ATTTAAATACATCTCATGTTAATGTTAATC	TTAAACCGCCTTTTGGATACATAGGTATCTTATGGTT
ATTTAAATACATCTCATGTTAATGTTAATC	TTTGATTTGTTTTAGTCTTCTTTTTTTTATACAA
ATTTAAATACATCTCATGTTAATGTTAATC	ACATAGTTACTTGGGCTTAAGTTATCTATTGTAGAT
ATTTAAATACATCTCATGTTAATGTTAATC	TCCAGCTAATGCTAGTGTATTACAAATAGATGGAA
ATTTAAATACATCTCATGTTAATGTTAATC	TTTATTCTTTTTGCTCGTACTAAACTATTATCTACA
ATTTAAATACATCTCATGTTAATGTTAATC	ATAGATGGATTTACTCAACTTGGATTCGATGCAAA
ATTTAAATACATCTCATGTTAATGTTAATC	AAAGTATTTAAAATAGAGAGGTGATAAATGATGAG
ATTTAAATACATCTCATGTTAATGTTAATC	AACTATATTAATTTCATCATCTTTTAAATCAATGTA
ATTTAAATACATCTCATGTTAATGTTAATC	CGAAAACTGATAATCCAAGTGACCCTGCTCCTTC
ATTTAAATACATCTCATGTTAATGTTAATC	CTTGTGCAACAGACTTAAACTTAACATTATCAGAA
ATTTAAATACATCTCATGTTAATGTTAATC	CCAACAGTTAATTTTTCCATCTTGACCTTTTATAT
ATTTAAATACATCTCATGTTAATGTTAATC	AAGGTAGGCATATTTAAGTAGATTTTAAGAAGCTTT
ATTTAAATACATCTCATGTTAATGTTAATC	TTTTACTGATACAAACACTAAAACTGATACTAAAAC
ATTTAAATACATCTCATGTTAATGTTAATC	ATAATGGTGGTAAATTCTACATGGTAATTCCTAA
ATTTAAATACATCTCATGTTAATGTTAATC	TATTCCGGAAATGTTGATATTTATTTAAAATTAGC
ATTTAAATACATCTCATGTTAATGTTAATC	GCAAATTTAATTTAAGGAGGAAATTATTATTATGTT
ATTTAAATACATCTCATGTTAATGTTAATC	ACTCATGTTACTATATGTTATACAAAAAGTGGTAG
ATTTAAATACATCTCATGTTAATGTTAATC	TAGTAAAAGTGAGGTTGAACATATGATAAAACATA
ATTTAAATACATCTCATGTTAATGTTAATC	TTATGGTTGCTCTGTTAGTGGATTTTCTTTTTCTGT
ATTTAAATACATCTCATGTTAATGTTAATC	ATTTAGAAATAGATAAAACTCAAGAGAATAGAAT
ATTTAAATACATCTCATGTTAATGTTAATC	GACTCACTTTTGTAAGGTCAGGTAATTCAGTTCGT
ATTTAAATACATCTCATGTTAATGTTAATC	TCATAAAGAAAATAAGAATCGCAAATATTAAAATATC
ATTTAAATACATCTCATGTTAATGTTAATC	ACGTAACTATTATTAGAATGAAACGTATTTATACT
ATTTAAATACATCTCATGTTAATGTTAATC	GGTTAATCCTAAATCAATTGCCCATTGTTCCATCAA
ATTTAAATACATCTCATGTTAATGTTAATC	TGACTTGGGTAAAGAACATCAGACTTTAGTTGTTAT
ATTTAAATACATCTCATGTTAATGTTAATC	TATCAATCAAATCCTCTTAGTGCATATTTCATCA
ATTTAAATACATCTCATGTTAATGTTAATC	TTCAAGGTATTCTGATTTTACATTTAGTCAGTTGAG
ATTTAAATACATCTCATGTTAATGTTAATC

>NC_022571|4|2|2818156-2820208|PILER-CR
ATTTAAATACATGTCATGTTAATGTTAATC	CTACACTTACTCTGTAGCTACCCCATGGCTTACT
ATTTAAATACATCTCATGTTAATGTTAATC	ATTTCTTCCTTTTCTGTTTGCTATATTGGCTAATTT
ATTTAAATACATCTCATGTTAATGTTAATC	ACTTTGAGCCAGTTATAGATAAGCTTATTAAATA
ATTTAAATACATCTCATGTTAATGTTAATC	AAGATGAATAATGAAAGGTATAGATATTTCAAATAA
ATTTAAATACATCTCATGTTAATGTTAATC	AGGTTAAAGTTATTACCAAAGAGTGTAATTACTGC
ATTTAAATACATCTCATGTTAATGTTAATC	TTAAACCGCCTTTTGGATACATAGGTATCTTATGGTT
ATTTAAATACATCTCATGTTAATGTTAATC	TTTGATTTGTTTTAGTCTTCTTTTTTTTATACAA
ATTTAAATACATCTCATGTTAATGTTAATC	ACATAGTTACTTGGGCTTAAGTTATCTATTGTAGAT
ATTTAAATACATCTCATGTTAATGTTAATC	TCCAGCTAATGCTAGTGTATTACAAATAGATGGAA
ATTTAAATACATCTCATGTTAATGTTAATC	TTTATTCTTTTTGCTCGTACTAAACTATTATCTACA
ATTTAAATACATCTCATGTTAATGTTAATC	ATAGATGGATTTACTCAACTTGGATTCGATGCAAA
ATTTAAATACATCTCATGTTAATGTTAATC	AAAGTATTTAAAATAGAGAGGTGATAAATGATGAG
ATTTAAATACATCTCATGTTAATGTTAATC	AACTATATTAATTTCATCATCTTTTAAATCAATGTA
ATTTAAATACATCTCATGTTAATGTTAATC	CGAAAACTGATAATCCAAGTGACCCTGCTCCTTC
ATTTAAATACATCTCATGTTAATGTTAATC	CTTGTGCAACAGACTTAAACTTAACATTATCAGAA
ATTTAAATACATCTCATGTTAATGTTAATC	CCAACAGTTAATTTTTCCATCTTGACCTTTTATAT
ATTTAAATACATCTCATGTTAATGTTAATC	AAGGTAGGCATATTTAAGTAGATTTTAAGAAGCTTT
ATTTAAATACATCTCATGTTAATGTTAATC	TTTTACTGATACAAACACTAAAACTGATACTAAAAC
ATTTAAATACATCTCATGTTAATGTTAATC	ATAATGGTGGTAAATTCTACATGGTAATTCCTAA
ATTTAAATACATCTCATGTTAATGTTAATC	TATTCCGGAAATGTTGATATTTATTTAAAATTAGC
ATTTAAATACATCTCATGTTAATGTTAATC	GCAAATTTAATTTAAGGAGGAAATTATTATTATGTT
ATTTAAATACATCTCATGTTAATGTTAATC	ACTCATGTTACTATATGTTATACAAAAAGTGGTAG
ATTTAAATACATCTCATGTTAATGTTAATC	TAGTAAAAGTGAGGTTGAACATATGATAAAACATA
ATTTAAATACATCTCATGTTAATGTTAATC	TTATGGTTGCTCTGTTAGTGGATTTTCTTTTTCTGT
ATTTAAATACATCTCATGTTAATGTTAATC	ATTTAGAAATAGATAAAACTCAAGAGAATAGAAT
ATTTAAATACATCTCATGTTAATGTTAATC	GACTCACTTTTGTAAGGTCAGGTAATTCAGTTCGT
ATTTAAATACATCTCATGTTAATGTTAATC	TCATAAAGAAAATAAGAATCGCAAATATTAAAATATC
ATTTAAATACATCTCATGTTAATGTTAATC	ACGTAACTATTATTAGAATGAAACGTATTTATACT
ATTTAAATACATCTCATGTTAATGTTAATC	GGTTAATCCTAAATCAATTGCCCATTGTTCCATCAA
ATTTAAATACATCTCATGTTAATGTTAATC	TGACTTGGGTAAAGAACATCAGACTTTAGTTGTTAT
ATTTAAATACATCTCATGTTAATGTTAATC	TATCAATCAAATCCTCTTAGTGCATATTTCATCA
ATTTAAATACATCTCATGTTAATGTTAATC

>NC_022571|4|4|2818156-2820274|CRISPRCasFinder
ATTTAAATACATGTCATGTTAATGTTAATC	CTACACTTACTCTGTAGCTACCCCATGGCTTACT
ATTTAAATACATCTCATGTTAATGTTAATC	ATTTCTTCCTTTTCTGTTTGCTATATTGGCTAATTT
ATTTAAATACATCTCATGTTAATGTTAATC	ACTTTGAGCCAGTTATAGATAAGCTTATTAAATA
ATTTAAATACATCTCATGTTAATGTTAATC	AAGATGAATAATGAAAGGTATAGATATTTCAAATAA
ATTTAAATACATCTCATGTTAATGTTAATC	AGGTTAAAGTTATTACCAAAGAGTGTAATTACTGC
ATTTAAATACATCTCATGTTAATGTTAATC	TTAAACCGCCTTTTGGATACATAGGTATCTTATGGTT
ATTTAAATACATCTCATGTTAATGTTAATC	TTTGATTTGTTTTAGTCTTCTTTTTTTTATACAA
ATTTAAATACATCTCATGTTAATGTTAATC	ACATAGTTACTTGGGCTTAAGTTATCTATTGTAGAT
ATTTAAATACATCTCATGTTAATGTTAATC	TCCAGCTAATGCTAGTGTATTACAAATAGATGGAA
ATTTAAATACATCTCATGTTAATGTTAATC	TTTATTCTTTTTGCTCGTACTAAACTATTATCTACA
ATTTAAATACATCTCATGTTAATGTTAATC	ATAGATGGATTTACTCAACTTGGATTCGATGCAAA
ATTTAAATACATCTCATGTTAATGTTAATC	AAAGTATTTAAAATAGAGAGGTGATAAATGATGAG
ATTTAAATACATCTCATGTTAATGTTAATC	AACTATATTAATTTCATCATCTTTTAAATCAATGTA
ATTTAAATACATCTCATGTTAATGTTAATC	CGAAAACTGATAATCCAAGTGACCCTGCTCCTTC
ATTTAAATACATCTCATGTTAATGTTAATC	CTTGTGCAACAGACTTAAACTTAACATTATCAGAA
ATTTAAATACATCTCATGTTAATGTTAATC	CCAACAGTTAATTTTTCCATCTTGACCTTTTATAT
ATTTAAATACATCTCATGTTAATGTTAATC	AAGGTAGGCATATTTAAGTAGATTTTAAGAAGCTTT
ATTTAAATACATCTCATGTTAATGTTAATC	TTTTACTGATACAAACACTAAAACTGATACTAAAAC
ATTTAAATACATCTCATGTTAATGTTAATC	ATAATGGTGGTAAATTCTACATGGTAATTCCTAA
ATTTAAATACATCTCATGTTAATGTTAATC	TATTCCGGAAATGTTGATATTTATTTAAAATTAGC
ATTTAAATACATCTCATGTTAATGTTAATC	GCAAATTTAATTTAAGGAGGAAATTATTATTATGTT
ATTTAAATACATCTCATGTTAATGTTAATC	ACTCATGTTACTATATGTTATACAAAAAGTGGTAG
ATTTAAATACATCTCATGTTAATGTTAATC	TAGTAAAAGTGAGGTTGAACATATGATAAAACATA
ATTTAAATACATCTCATGTTAATGTTAATC	TTATGGTTGCTCTGTTAGTGGATTTTCTTTTTCTGT
ATTTAAATACATCTCATGTTAATGTTAATC	ATTTAGAAATAGATAAAACTCAAGAGAATAGAAT
ATTTAAATACATCTCATGTTAATGTTAATC	GACTCACTTTTGTAAGGTCAGGTAATTCAGTTCGT
ATTTAAATACATCTCATGTTAATGTTAATC	TCATAAAGAAAATAAGAATCGCAAATATTAAAATATC
ATTTAAATACATCTCATGTTAATGTTAATC	ACGTAACTATTATTAGAATGAAACGTATTTATACT
ATTTAAATACATCTCATGTTAATGTTAATC	GGTTAATCCTAAATCAATTGCCCATTGTTCCATCAA
ATTTAAATACATCTCATGTTAATGTTAATC	TGACTTGGGTAAAGAACATCAGACTTTAGTTGTTAT
ATTTAAATACATCTCATGTTAATGTTAATC	TATCAATCAAATCCTCTTAGTGCATATTTCATCA
ATTTAAATACATCTCATGTTAATGTTAATC	TTCAAGGTATTCTGATTTTACATTTAGTCAGTTGAG
ATTTAAATACATCTCATGTTAATGTTAATC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022571.1\|WP_022746616.1\|2821747_2822242_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NC_022571.1\|WP_022746614.1\|2820449_2820740_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_022571.1\|WP_022746615.1\|2820739_2821738_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NC_022571.1\|WP_022746618.1\|2825094_2825895_-\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NC_022571.1\|WP_022746606.1\|2808341_2809931_+\|asparagine-synthase-B	unknown	unknown	gnl\|CDD\|236513
NC_022571.1\|WP_022746611.1\|2815772_2816288_-\|ClbS/DfsB-family-four-helix-bundle-protein	unknown	unknown	gnl\|CDD\|377957
NC_022571.1\|WP_022746607.1\|2810128_2812036_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_022571.1\|WP_077393793.1\|2806002_2806806_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NC_022571.1\|WP_022746621.1\|2828669_2829362_-\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NC_022571.1\|WP_022746605.1\|2806822_2807821_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378698
NC_022571.1\|WP_022746617.1\|2822424_2825016_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|350688
NC_022571.1\|WP_022746622.1\|2830491_2832066_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_022571.1\|WP_041716591.1\|2832641_2833043_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|227348
NC_022571.1\|WP_077393846.1\|2812603_2813212_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NC_022571.1\|WP_022746619.1\|2825898_2826876_-\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NC_022571.1\|WP_022746612.1\|2816315_2816837_-\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238496
NC_022571.1\|WP_022746620.1\|2826875_2828654_-\|crispr-associated-protein,-Csh1-family	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl\|CDD\|188234
NC_022571.1\|WP_022746610.1\|2813821_2815543_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NC_022571.1\|WP_022745633.1\|2804994_2805933_-\|transposase	unknown	unknown	gnl\|CDD\|376573
NC_022571.1\|WP_022746613.1\|2816967_2817669_-\|DUF1311-domain-containing-protein	unknown	unknown	gnl\|CDD\|377758

Protein	Function_ID	Function_description	E-value
NC_022571.1\|WP_022746616.1\|2821747_2822242_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.25816e-51
NC_022571.1\|WP_022746614.1\|2820449_2820740_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.23313e-23
NC_022571.1\|WP_022746615.1\|2820739_2821738_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.42592e-156
NC_022571.1\|WP_022746618.1\|2825094_2825895_-\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.63159e-56
NC_022571.1\|WP_022746606.1\|2808341_2809931_+\|asparagine-synthase-B	gnl\|CDD\|236513	PRK09431, asnB, asparagine synthetase B; Provisional.	0
NC_022571.1\|WP_022746611.1\|2815772_2816288_-\|ClbS/DfsB-family-four-helix-bundle-protein	gnl\|CDD\|377957	pfam08020, DUF1706, Protein of unknown function (DUF1706). This family contains many hypothetical proteins from bacteria and yeast.	2.54152e-72
NC_022571.1\|WP_022746607.1\|2810128_2812036_-\|sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.32276e-56
NC_022571.1\|WP_077393793.1\|2806002_2806806_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	9.89569e-15
NC_022571.1\|WP_022746621.1\|2828669_2829362_-\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	9.56627e-13
NC_022571.1\|WP_022746605.1\|2806822_2807821_+\|hypothetical-protein	gnl\|CDD\|378698	pfam11728, ArAE_1_C, Putative aromatic acid exporter C-terminal domain. This region is a presumed intracellular domain found in a set of bacterial presumed transporter proteins. The region is about 160 amino acids in length.	4.26579e-64
NC_022571.1\|WP_022746617.1\|2822424_2825016_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	6.96274e-31
NC_022571.1\|WP_022746622.1\|2830491_2832066_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	5.71953e-80
NC_022571.1\|WP_041716591.1\|2832641_2833043_-\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|227348	COG5015, COG5015, Uncharacterized conserved protein [Function unknown].	3.09308e-37
NC_022571.1\|WP_077393846.1\|2812603_2813212_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	8.64014e-06
NC_022571.1\|WP_022746619.1\|2825898_2826876_-\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.07449e-49
NC_022571.1\|WP_022746612.1\|2816315_2816837_-\|cysteine-hydrolase	gnl\|CDD\|238496	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.	4.47136e-55
NC_022571.1\|WP_022746620.1\|2826875_2828654_-\|crispr-associated-protein,-Csh1-family	gnl\|CDD\|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	1.25565e-20
NC_022571.1\|WP_022746610.1\|2813821_2815543_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	2.9226e-52
NC_022571.1\|WP_022745633.1\|2804994_2805933_-\|transposase	gnl\|CDD\|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.64403e-12
NC_022571.1\|WP_022746613.1\|2816967_2817669_-\|DUF1311-domain-containing-protein	gnl\|CDD\|377758	pfam07007, LprI, Lysozyme inhibitor LprI. This family consists of several bacterial proteins of around 120 residues in length. Members of this family contain four highly conserved cysteine residues. Family members include lipoprotein LprI from Mycobacterium, which binds to and inhibits macrophage lysozyme, which may aid bacterial survival.	4.63502e-09

>NC_022571.1|WP_022746613.1|2816967_2817669_-|DUF1311-domain-containing-protein
MIKNNKRIKLVIAAGVCAFMGLSATIMHLVNTNNNKNEQSAEVSKSEENPQSKDDEKNNEESASKPDVKEDTDKNKSESKSTNNVEKPTENKNKQTTGVKSKSSADSKTFTKVKGGGDYIKTLNAINSILDDPNLLDGSTLEMKSKVNQEYDLWDGYLNEIYKVISCNLPESEKRDLAKKENAWIKEKESKAKLAGDKYKGGTAENLAYSISAAKSTRDRCYELINTYMVTDD
>NC_022571.1|WP_022746612.1|2816315_2816837_-|cysteine-hydrolase
MVLLVIDTQNLITNEKLYKFDTFVSNVKEIINKARKNNIEVIYVRHDDGEGSELTKGTDGFEIYEEFQPINGEKIFDKNVNSAFKGTGLLEYLRKKDEKEIIIVGLQTDYCFDATIKCGFEHGFHMIVPAYSNTTVNNKFMSAEQSYRYHNEFMWNGRYAECISFDETIKRMK
>NC_022571.1|WP_022746611.1|2815772_2816288_-|ClbS/DfsB-family-four-helix-bundle-protein
MPDYKSKQELINEISSRAKLFIDEFSDIKETDKDKFIDGIDRTPVQMIAYQLGWLNLILDWEEQEKQGITVITPHANYKWNNLGGLYEDFYKQYENYTLHELCSMFEEAKEKIIHLTEGYTDMELFQSGGRKWASSTPANWALWKWIHTNTVAPFKSFRSKIRKWKKLNQS
>NC_022571.1|WP_022746610.1|2813821_2815543_-|methyl-accepting-chemotaxis-protein
MITLFKNLKVIHKLILCFGIVITVVIISGIMSYHKMREVNGNLDVIYSESLVKLSTIQDIRAHMADLTSGSLILVNPDKKAVVDKTISDMNGLIEKDNELTKKYEALINNEDDRKIFAEYLENLNSYNNAKDKFFEVAKGGDYDDIKNEFAIFDGYRAKINDLLDEEITYNEKNAKSKYEDSQIKCKNALFITVMFTIVAIGLSIIFSYLLVKNIDDALKKIKQFAGRIAKFDFSSNINIVGKDEFGETSASLNEAQSNIVHLLKNINDNSDDLKSDSEELSLTSNELMSKMEHMNSACKTIRGTIEENSAASEEITASIEEINSAVNELAQRALTARNVASKAKDNAENIQEKGKIAVDTTENLYKGKREAILKAIEEGKIVNKIKHMAEAIESIADQTNLLALNAAIEAARAGENGKGFAVVADEVRKLAEESKSAVNDINENIGKIDEAFDNISSGSNDILVFINEKVIPEFNSFVESGDHYYRDADYINNLSEELASTLEEFSATIGQISEAAQNVALNEQKSSEEVEVVGDIVKDTTKIAVNVSGTSQNQAKLAETLYDQVGKFKIKI
>NC_022571.1|WP_077393846.1|2812603_2813212_-|hypothetical-protein
MAVLLLAFNPMGASARVSENEAKDLILRYGNDDIFSYDYNYLKTNLVFSEEVSKDKLDDGLLGKGLYKITKSNENLYYFQLETDHYYVGVDSGQIYLYDGGSGCGTFHWIENNKVVKVWYWGRKEIDKDGQFGGWEYSDWQQNNGWVLLSDNTWSYYVDGLQKTGWIYDNGNWYYCYSNGQMAHDTTIAGYYLGSNGAWTNN
>NC_022571.1|WP_022746607.1|2810128_2812036_-|sensor-histidine-kinase
MKSIKSKLVLYLGVLIVIICIGLSVVSYINSSNALLSNLSKTLPSIAEQTASSVQGRIEGKLNTLESIAERSEIKDINNSWGNKMSILSDEGKRIGSVRLEIVDKNGDIKKADGKTSNVKERSYFKNAICGKSNVSDPLVNNTDKSVVVIYAVPIKDNDNQIIGVLIDTQDGNDLSELTNRVKVGKTGYAFMIKKDGTNIASTDKNKVINMHNPVEEVKTNPSFRAIADIEIKMGNGETGMGEYFSGADKYVGYAPVEGTEWSVGVIVLKSEILSELDTLKSWTVLVSVLFLLIGFLIIYIISSNIVKGIKSASKHLDLLANGNLYKEVSIKYLKQKDEIGAMTSSMKAMQQSLENMIKKIEEDSAKKIKETLKIQDEIFANVSHELKTPLNVIFSANQLTELYVKNSLIEDDKEKILKNINIIKQNCYRFMKLINNIVDISKMNSGFFKVNLSNENIVDVTEEIVQSISQYINAKHINIIFDTNTEEKIIACDPEKIERVILNLISNAIKFTNTDGSIFVNVIDKGDTVEIYVKDTGIGIEEKHLKNIFERFEQVDKSISRNAEGSGIGLSLVKSIVNMHGGKISVESEVGKGSIFKIELPVKIVEEIEVCEQTKACNNKIEMINVEFSDIYSI
>NC_022571.1|WP_022746606.1|2808341_2809931_+|asparagine-synthase-B
MCTIMCYTGTDMKHEKFAGSLQRTESRGPDMTEILTLPSGILGFQRLAIMDLSYSGMQPFTRKKDASICNGEIYGFRKLKDELMEKGHKFISDSDCEVLLPMYYEYGLDMFAKLDAEFATVIYDGENDTFIAARDPFGIRPLFYGYSESGKIMFASEAKNLVGLTDKIIAFPPGHYYADGKFTCYCDIAATEGEYCKDDLEVICKNIHDKLVTAIEKRMDADAPVGFLLSGGLDSSLVCSVAQKLYPEKKIKTFCIGMTEDAIDLKYAKEAADYIGSDHTAVYMTKEEVIDSLDEVIKLLGTFDITTIRASMGMYLLCKKIHEISDVKVLLTGEISDELFGYKYTDFAPNAGEFQKESQKRVRELYMYDVLRADRCISSNSLEARVPFGDLDFVKYVMAIDPEKKLNTYNMGKYLLRHAFEGDYLPNSILYRDKAAFSDAVGHSMVDYLKEYAEKCYSDDDFEKLCEKYAYHAKPFTKESLLYREIFEKHYPKQAEMIVDYWMPNKEWEGCNVNDPSARVLSNYGDSGK
>NC_022571.1|WP_022746605.1|2806822_2807821_+|hypothetical-protein
MKKYLQSKVFKMALSATIAITISNYIGLQFGVTSGVIAILTIQDTKKEALLIGGRRIITSTIAILLSFVLYMLLGNNPVVFGLFLLIFIPLTKVLKMEEGMVVGAVLSTHLLTSANINASWIINEAKLTVIGIGVAMFFNFYTASLEDEFEKNKKRIEDCYRALLSDMAVTLVTHAIPVYEQKLLLEVENLVKKSKDIARAINNNKLFKKNDYYVNYIDMRILQLDAMKKMNRHFSRFYMTYEQTKILSEFTNNVAMNLYEDNDCIELIDKLNLLRKDYANMELPKNRNEFENRALLFQFLNDLEDFLVIKRDFKKSVNINNKNTNTNADDK
>NC_022571.1|WP_077393793.1|2806002_2806806_+|helix-turn-helix-domain-containing-protein
MYFLQILFIQQPIVNKIDNLEYAEKRLKHGNFILDKNLLILSIPYKQKYEDYRHNFGLKQIINGLKRILGNCISTYHKDMIIFLISNSHQQVISESIKSSLLEFLKLNNLRCGISFVFENLSYIKDYFYQSINTLQLSSYMKINENLNYFEDYVEYYLFHMANNTTNDLHKINLSTLVHPWIKKLIKFDEENKAELFITLKTYLENNRNANNTSSKLNIHRSTFFYRLNKIQNLLDTSFDNGNNLLKLELSFKLLSYKLHNYGKLND
>NC_022571.1|WP_022745633.1|2804994_2805933_-|transposase
MIISLNIKSENDHYKIFEAVKIAFAKLNSNIQSTKGRPRKYSDEQIVACILYGVKSSIFSLRELEYRIKQDFVFRTIIQLNQVPDYSTFSLRTKILEKHIYYGIYAMFVELINPETRLCAIDGTALRSSKYDSEAKSGKGTRLGYYKGYKLHCIAAVSDIIIPLVFDLTTANVYDNQVSDLLYEAKIYNPFLILADAAYDSAGWFEIASSLEFNLLTDINMRKAKSIESFADKRYENALFLQSPIGLKLYKNRLKIEQLFSVLKGLYNLENPRLYGQARYERHIKWVLLAYLIDEFNKKQQGIKTRKYPWNL
>NC_022571.1|WP_022746614.1|2820449_2820740_-|CRISPR-associated-endonuclease-Cas2
MSKVSNYNYAFVFYDVNEKRVQRVFKVCKKYLSHFQKSVFRGEMSPSKLIKFKTDLNKVIDKNEDFICIIKLMNDNVFGEEVLGVTSGANGEDLII
>NC_022571.1|WP_022746615.1|2820739_2821738_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MGSTRYISSMGELTRKDDSLCFRKEGKNVYIPIENTKEIYCLNEVSINTKLLDFLSQNNVVVHFFNYYEGYSGTFYPKAQYNSGRLLVKQVEKHNNSRMTIAKAIVSGIGINIREVVYHYYKHNKKEVKGTVDWIKKEFFERIEKAQNIKELMSVEGEVWQRFYSEFKNFLPEDFIMNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISYLHEPSEGRFSLSLDISEVFKPVIVYKTIFDLVNNKRLQVNKHFDKKVNYCLLNEEGRNIFITAFEERLESVFLHPKLKRRVSYRTAIKLDCYKLIKYIMEEKEFIPFSLKEGM
>NC_022571.1|WP_022746616.1|2821747_2822242_-|CRISPR-associated-protein-Cas4
MRINGTLINYYFHCRRQCYLHGNRLNLEDNSETVKIGKAIHEEKASGSKNAEISIDNIKLDRLTSEYLTEIKKSDADIEAGKWQLIYYLKVLKSKGIIRKGKLECVEKNKTDKKIMYFELSDELEKELEKYVKEIENLILSEEIPKVLNKSKCKKCAYYEYCYI
>NC_022571.1|WP_022746617.1|2822424_2825016_-|CRISPR-associated-helicase/endonuclease-Cas3
MYFNENYFINIDNLLSKKYSFYAHLKNDRKETLKEHTELCKNYFNKLVDSKGLDRIFLNFEEIYLKNTSEKGKLLFRELLMNTIVLHDIGKINPFFQSRKMGNNSIEYSEKFCIIDSQHSIISAVLYLDYFMDKVLKLEKDDKKCIRLFMFLNAYIISKHHGNLEEFKKFLSSFDDDEVGFKVMSIFNNTYKDIYLKDFSLSEVKMKKACNNTNNYLKKIDKEKAVYLYTYERLLYSLLVACDFYATTEFMNGVELNEFGEIAEISEFYDIYKSTSVYRNIRKYENEDYYKDRKDLKNEKNINILRNEMFLDAEKELSKKINEDIFYLEAPTGSGKSNVSINLSFKLFEDNPTLKKIFYVYPFNTLVEQNLNTLNETFGENEDVFNRIAVINSISPIKMDENSKKGVDNEDNYEYYAKALLNRQFLNYPIILTTHVSLFNSMFNSLKESAFAFHQLVNSVIVLDEIQSYKNIIWAEIILFLKGFAKILNMKVIIMSATLPNLNILTSSKESTATLIEDRNKYFSNSLFKDRVKVSYELMDEDDTINALLNHVIDNSYKKKKILIEFIKKESAYNFYRKVKESIDMNDRINCSVELMTGDDNSIERQRILKSIKSSNAEKEGIILVATQVIEAGVDIDMDIGYKDISKLDSDEQFLGRINRSCKRRGVVYFFNLDRTDGIYKNDVRVNTELSLLDDDMKRILVEKNFEDYYLPVLNLIQERFNNTFNDSNLEKFLIEDVGQLNTRKVEERMKLIEEDNWNMSIYLARIINKEEENTTVNIDGKEVWESYKDLLANNSMQYAEKQVKLSEVKSKMNYFIYQINKNSDLLYNDKIGELYYIKNGEKYFDGEKLNKDKFKREVGIFV
>NC_022571.1|WP_022746618.1|2825094_2825895_-|type-I-B-CRISPR-associated-protein-Cas5
MKILKFTLSGKTAFFKKPDVNTYLYFTYGNIHRVSLLGMFGAILGYGGYNQMKKTDISKKAKKKDDENSIFPEFYEKLRDIKISIAPNNKKGFIPKKVQTFNNSVGYASKEQGGNLIVKEQWLENPSWDIYVLIDSEESEKVSEYILNHKAIYQPYLGKNDHYANITNIVVIENSEIVEINKLNIINSLFPKKLFEVDLEDEDEEEDELADDVYIEAFKYEEQLPIALDKKTNMYISEGFLYTNMKVSSHNNVNVYKVGERNIVFY
>NC_022571.1|WP_022746619.1|2825898_2826876_-|type-I-CRISPR-associated-protein-Cas7
MDKRIYGVLGISSIMGNWNADFTGYPKTTSDGIVFGSDKALKYPMKKMWENNGEKVLYIKSMRISNEKKGEIQVVPRNLKERYEYIFNTENLKYCKDTKEILTNLFKTIDVKNFGATFAEEGKNISITGAVQIGQGFNKYIGTYSETQQILSPFRDDSKAQKEAKKKKNENWEEEEDAKNSTLGNKIVSNEAHYFYPFTINPLAYKEFVELGVTDGYTEEDYKKFKKTSLVSATSFATNSKIGCENEFGLFVETDEDLYLPNLSEYISFNKGESKNTIELNCSDLINSVVDKVKAIEIYYNPYTTEIKSDIKGAKIYNIFTQEEV
>NC_022571.1|WP_022746620.1|2826875_2828654_-|crispr-associated-protein,-Csh1-family
MLKECLEVFKKKLDENGDKFIIDSYVLEQGTYLLIEPKGDSYQIREKIDIIFDKKTKEINGKSNSNFENICNYDYNSRIINTNKPMASGTFVNKRIIHSNNYFSFIVKKESLINGKLTNEIIDNYYETLSDPFIKYSKSQNAMKIYESVEKELGKVDKEIVERIRNWIKENIFNLDIDIKGKDYLKIFFEYPIKDYKREGKRYLVPNIYNSNEFNIIVKDKIYGLPNDNMGLNSKKPYLENKTRKIIVPYLIDNTNILLQKKFFDYLMNFVVIGRTNVYIDNCNNKIYVYENEELPDRNFKGIFLRIKLISNKTGKEVEIQDYDIITGYKPNLTRKFKFKNILNIEQNSKSVSIKEYGDYGKIKEMQQLLNDIFFQNKLIKNYFKESKDLLIDDSSLKSNLLLSRETIFNWIYKGIDNDIFPVLNKISLSLLKGSIKNGYISKAKHQFNLRWSLIYYFKEGKRMAEILNEVNEVLRKKINSKEYDPIENDEQYYFSVGQVVAFLLSKYRGKNKPFSLAKPIVNSKNNEIIKENLRKMYNKYSYDPSINIKRFKNFYVMISGYIPEGKVNQDMIIAGFLSNSLVYEKDKEENK
>NC_022571.1|WP_022746621.1|2828669_2829362_-|CRISPR-associated-endoribonuclease-Cas6
MNVFQIKLKIFVLKDIPIEDSQGTVSAFIDSGLIKDEKLLEFHESNKFKGYCFDAPYPLEDDKIYKKDKIYTITIRTIDKNLAEFFANKLVNEFNENVKGLTSEIRILPKKHIEKLYSITPAVMKNEDGYWKNKIKLDDFERRLKENLIKKYNSTMNLKIDEDFQLYTSIEFKNKKPISTKYKNIKLLGDKISLNIAENENAQKLAYMSLGTGIFEMNARGYGYVNYRWL
>NC_022571.1|WP_022746622.1|2830491_2832066_-|MFS-transporter
MNENPKSRILLVGLLLGIFFSSLDQTIVGTAMPRIIGDLGGLSIMAWVTTAYLLSSTTVVPIAGKMSDLFGRRIMYVGGLVLFMIGSMLCGTSQNMTQLIFYRGLQGIGGGILMPMAMTIIGDIFPPEKRGKWQGVISAVFGLSSIVGPSIGGWFVDNATWRWVFYINLPVGLLAAITVFIGLSGEKRVEEKVIIDYAGALTLVIFIVSLLLGLSLGGKDYPWISWQIIGLFALFLIFCIVFIFIELKAEDPILNLHLFENKVFVGANIVGFLMGLGMFGAMMFLPLFMQGIIGISATKSGNSMIPMMLGMMVTSVAGGQLVTKVKFRTLFILGIALMGISLYLLSTMNVDTTSFTVSLYIIILGLGLGLIMPTITLAVQSTFSIEQRAVATSATQFFRSIGSTLGVTILGVVLNNRSATILDESFFPITDKIAALQTGALGTMLQNAHNDPQSLFNTLLSPEILNKIPSQLQQIMIPPLKSALADSLHTVFFVCTIIVLLGIPASFLLGESKIKNKTKMSGKK
>NC_022571.1|WP_041716591.1|2832641_2833043_-|pyridoxamine-5'-phosphate-oxidase-family-protein
MKEVVEFLQANSVQYLATVGRDGKAKCRPFMFCLEMEGKLWFCTNNTKDVYKDMQANPEIEICVSSPKYAWIRLNGKAVFENNMAVKEACMANPIVKGQYNEASNPIFEVFYLENAKAIIADFSGNPPKEYNL

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Crispr_ID: NC_022571_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022571_5

4329880-4329980

Orphan

Consensus_repeat	Method
TAGCACATTATAATCTTCTCACATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022571_5

>merge|NC_022571|5|4329880-4329980|CRISPRCasFinder
TAGCACATTATAATCTTCTCACATTAAAAAAAGTGCGCTAGCACATTATAATCTTCTCACATTAAAAAAAGTGCGTTAGCACATTATGATCTTCTCACATT

>NC_022571|5|5|4329880-4329980|CRISPRCasFinder
TAGCACATTATAATCTTCTCACATT	AAAAAAAGTGCGCTAGCACATTATAATCTTCTCACATTAAAAAAAGTGCGT
TAGCACATTATGATCTTCTCACATT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022571.1\|WP_022749076.1\|4320522_4321536_-\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|183400
NC_022571.1\|WP_022749088.1\|4323243_4324290_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|184529
NC_022571.1\|WP_022749119.1\|4334298_4335027_-\|FliA/WhiG-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274153
NC_022571.1\|WP_022749094.1\|4325882_4326311_+\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022749069.1\|4318010_4318220_-\|ferrous-iron-transport-protein-A	unknown	unknown	gnl\|CDD\|377199
NC_022571.1\|WP_022749072.1\|4318926_4319991_-\|polysaccharide-deacetylase	unknown	unknown	gnl\|CDD\|200569
NC_022571.1\|WP_022749126.1\|4335718_4336591_-\|MinD/ParA-family-protein	unknown	unknown	gnl\|CDD\|349758
NC_022571.1\|WP_022749112.1\|4333525_4333711_-\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022749108.1\|4332747_4333524_-\|flagellar-basal-body-rod-protein-FlgG	unknown	unknown	gnl\|CDD\|183768
NC_022571.1\|WP_041716366.1\|4333719_4334247_-\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022749080.1\|4322093_4322336_-\|TIGR04540-family-protein	unknown	unknown	gnl\|CDD\|275333
NC_022571.1\|WP_022749092.1\|4324526_4325480_-\|DUF4003-domain-containing-protein	unknown	unknown	gnl\|CDD\|379047
NC_022571.1\|WP_022749122.1\|4335065_4335707_-\|flagellar-brake-domain-containing-protein	unknown	unknown	gnl\|CDD\|227868
NC_022571.1\|WP_022749084.1\|4322531_4322963_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NC_022571.1\|WP_022749100.1\|4330078_4331725_-\|putative-manganese-dependent-inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|237843
NC_022571.1\|WP_022749097.1\|4327076_4329629_-\|calcium-translocating-P-type-ATPase,-PMCA-type	unknown	unknown	gnl\|CDD\|319781
NC_022571.1\|WP_022749128.1\|4336584_4337877_-\|flagellar-biosynthesis-protein-FlhF	unknown	unknown	gnl\|CDD\|235570
NC_022571.1\|WP_022749065.1\|4317775_4317997_-\|ferrous-iron-transport-protein-A	unknown	unknown	gnl\|CDD\|224830
NC_022571.1\|WP_022749132.1\|4337877_4339944_-\|flagellar-biosynthesis-protein-FlhA	unknown	unknown	gnl\|CDD\|235672
NC_022571.1\|WP_022749104.1\|4331951_4332731_-\|flagellar-basal-body-rod-protein-FlgG	unknown	unknown	gnl\|CDD\|183767

Protein	Function_ID	Function_description	E-value
NC_022571.1\|WP_022749076.1\|4320522_4321536_-\|tryptophan--tRNA-ligase	gnl\|CDD\|183400	PRK12282, PRK12282, tryptophanyl-tRNA synthetase II; Reviewed.	0
NC_022571.1\|WP_022749088.1\|4323243_4324290_-\|DNA-polymerase-IV	gnl\|CDD\|184529	PRK14133, PRK14133, DNA polymerase IV; Provisional.	0
NC_022571.1\|WP_022749119.1\|4334298_4335027_-\|FliA/WhiG-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274153	TIGR02479, RNA_polymerase_sigma_factor_WhiG, RNA polymerase sigma factor, FliA/WhiG family. Most members of this family are the flagellar operon sigma factor FliA, controlling transcription of bacterial flagellar genes by RNA polymerase. An exception is the sigma factor WhiG in the genus Streptomyces, involved in the production of sporulating aerial mycelium.	6.13348e-86
NC_022571.1\|WP_022749069.1\|4318010_4318220_-\|ferrous-iron-transport-protein-A	gnl\|CDD\|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	2.83869e-12
NC_022571.1\|WP_022749100.1\|4330078_4331725_-\|putative-manganese-dependent-inorganic-diphosphatase	gnl\|CDD\|237843	PRK14869, PRK14869, putative manganese-dependent inorganic diphosphatase.	0
NC_022571.1\|WP_022749126.1\|4335718_4336591_-\|MinD/ParA-family-protein	gnl\|CDD\|349758	cd02038, FlhG-like, MinD-like ATPase FlhG. FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) is a major determinant for a variety of flagellation patterns. It effects location and number of bacterial flagella during C-ring assembly.	3.24165e-99
NC_022571.1\|WP_022749108.1\|4332747_4333524_-\|flagellar-basal-body-rod-protein-FlgG	gnl\|CDD\|183768	PRK12818, flgG, flagellar basal body rod protein FlgG; Reviewed.	7.95223e-116
NC_022571.1\|WP_022749080.1\|4322093_4322336_-\|TIGR04540-family-protein	gnl\|CDD\|275333	TIGR04540, CLB_0814_fam, conserved hypothetical protein. Members of this family are conserved hypothetical proteins in a narrow range of species. In Clostridium botulinum A ATCC 19397, the gene occurs immediately after a five gene operon for biosynthesis of the natural product bacimethrin, a thiamin antivitamin antibiotic.	4.17444e-23
NC_022571.1\|WP_022749092.1\|4324526_4325480_-\|DUF4003-domain-containing-protein	gnl\|CDD\|379047	pfam13170, DUF4003, Protein of unknown function (DUF4003). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 327 and 345 amino acids in length.	2.97189e-101
NC_022571.1\|WP_022749122.1\|4335065_4335707_-\|flagellar-brake-domain-containing-protein	gnl\|CDD\|227868	COG5581, COG5581, c-di-GMP-binding protein [Signal transduction mechanisms].	2.86902e-16
NC_022571.1\|WP_022749084.1\|4322531_4322963_-\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	6.43179e-20
NC_022571.1\|WP_022749072.1\|4318926_4319991_-\|polysaccharide-deacetylase	gnl\|CDD\|200569	cd10944, CE4_SmPgdA_like, Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins. This family is represented by a putative polysaccharide deacetylase PgdA from the oral pathogen Streptococcus mutans (SmPgdA) and Bacillus subtilis YheN (BsYheN), which are members of the carbohydrate esterase 4 (CE4) superfamily. SmPgdA is an extracellular metal-dependent polysaccharide deacetylase with a typical CE4 fold, with metal bound to a His-His-Asp triad. It possesses de-N-acetylase activity toward a hexamer of chitooligosaccharide N-acetylglucosamine, but not shorter chitooligosaccharides or a synthetic peptidoglycan tetrasaccharide. SmPgdA plays a role in tuning cell surface properties and in interactions with (salivary) agglutinin, an essential component of the innate immune system, most likely through deacetylation of an as-yet-unidentified polysaccharide. SmPgdA shows significant homology to the catalytic domains of peptidoglycan deacetylases from Streptococcus pneumoniae (SpPgdA) and Listeria monocytogenes (LmPgdA), both of which are involved in the bacterial defense mechanism against human mucosal lysozyme. The Bacillus subtilis genome contains six polysaccharide deacetylase gene homologs: pdaA, pdaB (previously known as ybaN), yheN, yjeA, yxkH and ylxY. The biological function of BsYheN is still unknown. This family also includes many uncharacterized polysaccharide deacetylases mainly found in bacteria.	4.14413e-77
NC_022571.1\|WP_022749097.1\|4327076_4329629_-\|calcium-translocating-P-type-ATPase,-PMCA-type	gnl\|CDD\|319781	cd02089, P-type_ATPase_Ca_prok, prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1. Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_022571.1\|WP_022749128.1\|4336584_4337877_-\|flagellar-biosynthesis-protein-FlhF	gnl\|CDD\|235570	PRK05703, flhF, flagellar biosynthesis protein FlhF.	5.08004e-144
NC_022571.1\|WP_022749065.1\|4317775_4317997_-\|ferrous-iron-transport-protein-A	gnl\|CDD\|224830	COG1918, FeoA, Fe2+ transport system protein A [Inorganic ion transport and metabolism].	8.05302e-20
NC_022571.1\|WP_022749132.1\|4337877_4339944_-\|flagellar-biosynthesis-protein-FlhA	gnl\|CDD\|235672	PRK06012, flhA, flagellar type III secretion system protein FlhA.	0
NC_022571.1\|WP_022749104.1\|4331951_4332731_-\|flagellar-basal-body-rod-protein-FlgG	gnl\|CDD\|183767	PRK12817, flgG, flagellar basal body rod protein FlgG; Reviewed.	1.2305e-111

>NC_022571.1|WP_022749097.1|4327076_4329629_-|calcium-translocating-P-type-ATPase,-PMCA-type
MIQEKELTAGLSTKEAEKRIEKFGFNELQHHKKASAFKIFLSQFNNFIVWVLIAATIISGIIGDRADAITILIIVVINSILGFIQEFKTEKSLEALKDLAAPTCKVLRDSSIQIINSIYLTIGDVVILEAGDRIPADGFFIESSGIVVDESLLTGESVGVNKDSKNKKANSGFMGTTVVKGKGLFKVDCIGMKTEMGKIADLIQNIEEEKSPLNKKLDSLGKILVVICLVICAIVTIMGIMRGNDITEMFLLGVSLAVAAIPEGLAAIVTVALALGVSRMLKRNALVRKLPAVETLGCTSVICSDKTGTLTQNKMTVKEVYLNGRIYELDKEKLNDYTKFMKCLVYCNDCNYDFTKKKMSEALHGDPTETALINMFFKEVPVLESFQSNANRVFDIPFDSTRKMMSVIVNEGGKETCYVKGAPERMIDKCEFILENNKIKPFTYQKKKQVSQFITAMSSRALRCLAAAYKEENLVKSEKLENNLIFLGITGSIDPPRKEAVDAVLKCKLAGIKPVMITGDHQNTALAIAKYLNICSTEDQVMTGQQIEAVSDSELEKRVKKVRVFARVSPSHKLRIVRAFKKTGNIVAMTGDGVNDAPAIKESDIGIAMGISGTDVTKEASSMILMDDNFSTIVAAVEEGRIIYDNIRKFIRYLLSCNLGEVLTMFLATLFYLPNPLSPIQILLVNLATDGLPAIALGVDPAESDIMRQQPREKGESIFARGLVEKIIVRGTLIGLCTLLSFMVGRYYGMNLETCRTLALCTLVMSQLIHVFECRSERHSIFEIKLFTNPWLVGAVLISVILICSVLYVPFLQQVFHTVPLSVKQVLIVMFFSGIIAFINSVYLLIKSKY
>NC_022571.1|WP_022749094.1|4325882_4326311_+|hypothetical-protein
MSLKDKLSSKFSNYFQNAYMQKYGDRITSVSGTVLSVKFLEKNYFIMKSLVIEMVIKPEVGKKVVKCWYKKNRWFKKPEFILVKQGHKVIIMGVTGEKNSKKENSQEVQIMNVLNLTTKKDLVPVDHSQIRKSRQQAMNMRR
>NC_022571.1|WP_022749092.1|4324526_4325480_-|DUF4003-domain-containing-protein
MNNRIKEVCDITIKNYKHAMQNLRYDGDYINHFSALLNGYHKNKIPVDKVKEIRTFIKKSTSKMSVFRGDMLYILSFLIANQEKENFEITNSVLDTFNLLVEEGFKECEYLTLVSYSIVKYCDHENRCIIIKRMKNIFNIIKQKYGNLTKEDDYLLCALLAISGAKFDCMTEYMEFIFNYIKDLKLFSNNGVQGLTNSILLNSNENAADKASQLVKALEKNDIKIGNQFLQLLGVLVGEENINESIGLIKQTIEYLCTEESEYNFYIDKDFRNMIAFVIVFMDNRDKEMRYVDELMAFGTYSFLVSKNQGIFNEILA
>NC_022571.1|WP_022749088.1|4323243_4324290_-|DNA-polymerase-IV
MENKILHVDMDAFFASVEQRDNPELRGKPVIVGGVSERGVVSTCSYEARKYGVHSAMPIFMAREKCPNGIFVSGRYGKYTKVSQEIFKLFNELTPLVEPVSIDEGFLDLSEAKIKDGMEAARYIKNRVYREIGLTLSIGISYNKFLAKLASDWNKPNGIKEITKEMIPDILLPLSISKVHGLGKISVAKLNNMGIYYIKDLYNMPKEFYLEYLGKSGIDIYNRIRGIDNRKVEVVRERKSVGKERTLKFDTKIKEELLEYIKEFSFEIEDILSRKNVMGKTVTLKYKTKDFENHTRSKTLNYYVNTQIEIFEIAKELLEAEQLKDEIRLIGVSVSSFKENELQQITLF
>NC_022571.1|WP_022749084.1|4322531_4322963_-|universal-stress-protein
MNKRKILIPIDGSERSMHSLEFVKEIFPKGSVDIIIMNVKELVLINEMIVADEIKLAQELGKDILEAAKEKMKDYKTETYFAFGYPADEIIKKAKEENIGIIVMTKSTKKGLTRMIGSVTVNVVKRAKCIVMIVPNDFTISIR
>NC_022571.1|WP_022749080.1|4322093_4322336_-|TIGR04540-family-protein
MRAVYRNPRELATCLKDIVDTYYDDLISYEKMEEKILKIVEANKDAIYKEKSMSTKIANVLGNKREAIIDEIVEKNKKEA
>NC_022571.1|WP_022749076.1|4320522_4321536_-|tryptophan--tRNA-ligase
MDKKIILTGDRPTGKLHIGHYIGSLKNRVELQKSGLYESFIMIADQQALTDNARNPEKIRNSLTEVALDYLAVGLDPAKSTIFVQSQIPELNELTMHYLNLVTLSRLERNPTVKQEIKQKNFENSIPAGFLIYPVSQAADITAFKATTVPVGEDQLPMIEQTREIVRSFNSIYGDILVEPEAVLPPSNAGRLPGTDGKAKMSKSIGNCIYLSDDADTIKKKVMSMYTDPNHIRVEDPGQVEGNTVFTYLDVFAKDKEVVEEMKEHYKRGGLGDMKVKRYLNEVLQAELEPIRNRRMEFEKDMDAVYAMLKDGSDKARAVASQTLSEVRNAIGIEYFK
>NC_022571.1|WP_022749072.1|4318926_4319991_-|polysaccharide-deacetylase
MTLRKKEMNNRKEEGTKRENLNKLESEKETNEYNKEDLKALEERNIKNDDNEKKKLIITNEKSFIRGMIVLMMMIFLGNGAICKACAQAGNNNPISLFQQNDSKESDNKQKDTEEKKDSTMVGTSEEGKKYAYDAVEVERKLKNYDYSNNGKKMVFLTFDDGASTTVTPKILETLDKYDVKATFFVMGKTIEDGGETAKTLIRKEFNSGHAIGNHSYSHDYKVLFPGRSLNFQDFKADFDKNDKILKDILGDNFSTRVIRCPGGHMSWKNMAPLDEYLSDNNMASIDWSAYDSDAEGKKKTANELVNYAIKSAKGKDMVVMLMHDTYGKEETAKALPQIIEYFKQQGYEFRTLA
>NC_022571.1|WP_022749069.1|4318010_4318220_-|ferrous-iron-transport-protein-A
MPLILANLGSQMNIKKIKGNDETRRFLSSLGFITGEVVTVISEFGGNLIINVKDTRVALDKGMASRIIV
>NC_022571.1|WP_022749065.1|4317775_4317997_-|ferrous-iron-transport-protein-A
MSTLKEAKCGETVRVKKVDGEGAVRRRIMDMGITRGCEIYVRKVAPLGDPVEVTVRGYELSLRKADAEMIILQ
>NC_022571.1|WP_022749100.1|4330078_4331725_-|putative-manganese-dependent-inorganic-diphosphatase
MENVVYVTGHKNPDSDSICAAYGYAELKNKTSDLPAVPVRLGNVNAETQFILDYFGVKAPKLLETVKLKVEDLEIDKISPILPSISLKMAWNIMRDNHSKSLPVVDENERLLGILSISNLTSAYMDIWDNNILGKSNTSIENIIDTLAATPIYINENVKTFDGKIAVTAMQPESLREIVDEGDIAIVGDRPDVQQALIDIKTSLIIVTGSHKLDENLLSEAKENGVTVISTPHDSFTASRLIVQSIPVGYVMATENLISFSNDELVEDIKEVMAETRYHSYPVTDADNKVVGTVARYHLISNHKKKVIQVDHNERGQSVDGLEEAEVLEIIDHHRVADIQTNNPIYFRNEPIGSSSSIVAKCYFEHGVTPSKEVAGLLCGAIISDTLLFKSPTCTEQDRTICTKLAEIAGIQSLEDFAKEMFKAGTSLVGKSVAEIFNQDFKPFSMGEAKVGVAQVNTMDIEGFMPLKDEMLSYMASEADNKKYDVVMLLLTDILTEGSQVLVAGNRPDYVEKTFNVTLKDSMAFLPGVLSRKKQVIPPLTNVVNSMK
>NC_022571.1|WP_022749104.1|4331951_4332731_-|flagellar-basal-body-rod-protein-FlgG
MFNIFATGKSGMSAYQEKLDYLSNDLVNSQTIAYKNTDVGFKDLLVESLDRQGTPLVTKTAVNGTGVKLGTNYAVNKQGNLKNTGIKTDLAIDDGTGQGYFALTQSDGSIAYTRNGNFKIDSNGVLVDATGTKVYINYEAGMSEGSPQLESEKISVDEQGGLYMNSGTDMVKIGTIPVFTAIGDKAFIPQGNSHFVPSADAQITQSTNYDIRQGFLEASTVDPTEVFSDVILTQRAFQLSSKAITAADDIWGMINNMRS
>NC_022571.1|WP_022749108.1|4332747_4333524_-|flagellar-basal-body-rod-protein-FlgG
MIRGFYTSLSGLITLQNEQETITNNIANVNNTGYKKRELTKQSFEDVMISNRQKLSGDQYVRNDLGTLNLGVKTYDVKTAFTQGTFKSTGNMTDFAISGRGFFVAQSGNKEVYTRDGNFKIDQQGYLITNDGSKVLGVNNTTGAHEPIYVGDKKFSLDADNNINIEGTGATDKLLTADFSGSDYKKLEPMGDNYITDQSPTYNAKVDVTQNTLEGSNVDSASELIKLMEVKRQFETNQKFVKMQDETVQKAATELGRV
>NC_022571.1|WP_022749112.1|4333525_4333711_-|hypothetical-protein
MSFFIDKRIFLGIGIGLILGVTFMIGYKYTISLSDSQIEQRARDLGMIYENERKSILKGEG
>NC_022571.1|WP_041716366.1|4333719_4334247_-|hypothetical-protein
MPIVLIIIGVVLIIYNYRAIKREENTSNFSFENILNNNKEDVNDYKIELGIIRRDIAESLTELQQEIIEIKNELNILKNVEEVYENKAEIENNKNEYTESNDDNNVEESNIEINLDIDKEVISEINFSEIKKNIDSSKTESIKKLLLDGLTEEQICRELSISKGEVLLVKGLFKK
>NC_022571.1|WP_022749119.1|4334298_4335027_-|FliA/WhiG-family-RNA-polymerase-sigma-factor
MNTAREVDGKEQVIQEYIPLVKYIASRVMFSKNKYMEYEDLVSYGMIGLMDALNKFDNTKGMKFSSYASIRIKGAMIDELRKNRPLSKGAMDKLNRYNKAIDDLQGQLLREPTDNEIAKYLNISLNEITEIENYINYISMVSLENVIFSEDEDINFMGIIEDKNSPSPDMYVQDKEQLEILTQAIELLKEKDRTILNLYYYEGLTLKEIGNVLGVSESRVCQLHSRAIRNLRESMKKLHYID
>NC_022571.1|WP_022749122.1|4335065_4335707_-|flagellar-brake-domain-containing-protein
MHSFNLEINDRIEVIVNEKPYKSLVIDIDDDVIKINLPANEGQYLMLHSGEKIEVNAYLENGNCFNFYSKVISKGKDGNILYYELEEPFNITAIQRRNFFRVGMVNSVQYKNITNIHEEDFEDIPFKEALMVDLSGGGIKLKLKEKVSKDDLFFIKMKIKQKEFLLKGDIVRIEETYDNERLCGIRFLDITEAQSDIIIEELFEIMRKQRARS
>NC_022571.1|WP_022749126.1|4335718_4336591_-|MinD/ParA-family-protein
MLDQAETLRQLITKEEENIKKEQENDYAKIITVTSGKGGVGKSNFVVNLAICLSNRGKKVLIFDADLGMGNDDILMGVYPKYNIFDIIGTDLKLEEIIIEASNGVSLIPAGSGLNKVQELTEAEKKMFIEKLGELGEYDYILMDTGAGVNRDVLSFVSASEELIIITTPEPTALTDAYSLMKATDHFKLKSEAKIVVNKAFTKEEGKETYDKFDKAVKRFLSMKISYLGCILDDRKLVQSVRQQKPFTMLFPNCDASKCVDEIAMKIIGQNINSTGGVRGVFKRLFNIFS
>NC_022571.1|WP_022749128.1|4336584_4337877_-|flagellar-biosynthesis-protein-FlhF
MVIKRYLVSNMNEALTRIRYELGKDAIIISQRKVKKSGIKGWFSKKVIEVTAAVENFEEEKSTLNSEQEFRNSLENIKKLMESEVRIKKDVENVKDTINNRILEHNANVEKESPKATKYQENYMENINHVNDKTSIIQSENNMEQSGDKRDFESVHKEVSDLKSLLNKVIQNTSVDENPINYLQEKLSQLDIDEKFHDEIIKSIDEEFSKEVDETERLRDIFERNVLVSKKRLNGRVVLVGPTGVGKTTTIAKLAGRLALVEKKKVGLITVDTYRIGAIEQLKTYAEIMNIPFKVVITMKEMEDAIEFMEDCDVVLIDTTGRSSKNTMQISELRAFVQKANPQHISMVISATTKNKDIMSILNGYSELSYDNIIITKLDETTVYGSLYNISKSANKPINFITTGQNVPDDIRTSSKEEIARFILGEETLC
>NC_022571.1|WP_022749132.1|4337877_4339944_-|flagellar-biosynthesis-protein-FlhA
MVLGGKKLDIKENLDIIVAFGVIGIVLMIIIPLPKILLDLLLALNITISIIIMLITMFTTNVLQLSVFPTLLLVTTLFRLGLNISSTRLILTEGDAGHIITAFGNFVIRGNYVVGIIIFLIIVVIQFMVITNGAGRVAEVSARFTLDAMPGKQMSIDADLNSGMIDEATARKRRQDLQSEADFYGSMDGASKFVKGDAVAAIIITVINILGGIVIGVLQRGLSVGDAAGTYAILSVGDGLVSQVPALLISTASGILVTRSGSADNFGKTMTAQLTAFPIATGVASAIMLFLGLVPNMPKLAFFTASIATGVLTYMLYKEEAAKQVEEYVSEEEEIIQAERKEPENVMNLISVESMEVEIGYGLIPLADEASGGDLLQRIASVRRQCAIEMGIVVQPIRIRDNLQLKTNEYIIKIRGTMVVSSELMPSMLLCMDPTGENSEIPGIKTIEPTFGLPAIWINKDQREEAEIKGLTVVDPTTVMVTHLTETIKTHSYELLGRQEVQLIVENAKEKYSAVVEELIPDLLTIGELQKVLQNLLREKVPIKDIVTIMESLADNARNTRDLEVLTEYVRFALARTICNQVIDEERKITVVTLDPNVEEIIANNIQKSVQGSFPTVDPDTTTKILTSIKETLESVYFYNNQPIILVSPNIRAVFRKLIEMVFPHVMVISLNEVPNDVQINSEGVVRL

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Crispr_ID: NC_022571_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022571_6

4536584-4536756

Orphan

Consensus_repeat	Method
CCTATACTTGTTATACTGTTTGGGATTGTTATTGA	PILER-CR

2 spacers

The CRISPR arrays of NC_022571_6

>merge|NC_022571|6|4536584-4536756|PILER-CR
CCTATACTTGTTATACTGTCTGGAATTGTTATTGACGTTAATCCCATACAGTAAGTAAATGCAGAAGCCCCTATACTTGTTACACTGTTTGGGATTGTTATTGACGTTAAACCAACACAACCCAAAAATGCACTATCACCTATACTTGTTATACTGTTTGGGATTGTTATTGA

>NC_022571|6|3|4536584-4536756|PILER-CR
CCTATACTTGTTATACTGTCTGGAATTGTTATTGA	CGTTAATCCCATACAGTAAGTAAATGCAGAAGCC
CCTATACTTGTTACACTGTTTGGGATTGTTATTGA	CGTTAAACCAACACAACCCAAAAATGCACTATCA
CCTATACTTGTTATACTGTTTGGGATTGTTATTGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022571.1\|WP_022749747.1\|4529757_4532208_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NC_022571.1\|WP_022749715.1\|4522305_4523121_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NC_022571.1\|WP_169729035.1\|4532616_4532913_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NC_022571.1\|WP_140395238.1\|4532304_4532439_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226654
NC_022571.1\|WP_022749790.1\|4548990_4549932_+\|methyl-accepting-chemotaxis-sensory-transducer	unknown	unknown	gnl\|CDD\|214599
NC_022571.1\|WP_022749773.1\|4545357_4546440_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|336785
NC_022571.1\|WP_022749764.1\|4542234_4542981_-\|methyltransferase	unknown	unknown	gnl\|CDD\|334594
NC_022571.1\|WP_022749729.1\|4524525_4524936_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_022571.1\|WP_022749786.1\|4548285_4548960_+\|DUF2225-domain-containing-protein	unknown	unknown	gnl\|CDD\|378340
NC_022571.1\|WP_022749739.1\|4526380_4527949_-\|acyl-CoA:acetate/3-ketoacid-CoA-transferase	unknown	unknown	gnl\|CDD\|227016
NC_022571.1\|WP_022749769.1\|4543969_4545304_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226382
NC_022571.1\|WP_022749782.1\|4547327_4548119_-\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NC_022571.1\|WP_022749743.1\|4528059_4528836_-\|short-chain-enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|180270
NC_022571.1\|WP_022749794.1\|4551665_4552757_-\|glycosyl-hydrolase-53-family-protein	unknown	unknown	gnl\|CDD\|226385
NC_022571.1\|WP_022749777.1\|4546457_4547237_-\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_041716839.1\|4524043_4524391_-\|four-helix-bundle-copper-binding-protein	unknown	unknown	gnl\|CDD\|153434
NC_022571.1\|WP_022749765.1\|4543192_4543525_+\|HesB-like-protein	unknown	unknown	gnl\|CDD\|188182
NC_022571.1\|WP_022749734.1\|4525154_4526294_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173847
NC_022571.1\|WP_022749719.1\|4523327_4523927_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|334163
NC_022571.1\|WP_022749755.1\|4539036_4540170_-\|response-regulator	unknown	unknown	gnl\|CDD\|226456

Protein	Function_ID	Function_description	E-value
NC_022571.1\|WP_022749747.1\|4529757_4532208_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NC_022571.1\|WP_022749715.1\|4522305_4523121_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	2.95915e-96
NC_022571.1\|WP_169729035.1\|4532616_4532913_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	6.9894e-11
NC_022571.1\|WP_140395238.1\|4532304_4532439_+\|sensor-histidine-kinase	gnl\|CDD\|226654	COG4191, COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms].	7.51598e-09
NC_022571.1\|WP_022749790.1\|4548990_4549932_+\|methyl-accepting-chemotaxis-sensory-transducer	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.14309e-33
NC_022571.1\|WP_022749773.1\|4545357_4546440_-\|AAA-family-ATPase	gnl\|CDD\|336785	pfam07728, AAA_5, AAA domain (dynein-related subfamily). This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.	3.78985e-09
NC_022571.1\|WP_022749764.1\|4542234_4542981_-\|methyltransferase	gnl\|CDD\|334594	pfam01564, Spermine_synth, Spermine/spermidine synthase domain. Spermine and spermidine are polyamines. This family includes spermidine synthase that catalyzes the fifth (last) step in the biosynthesis of spermidine from arginine, and spermine synthase.	4.44431e-06
NC_022571.1\|WP_022749729.1\|4524525_4524936_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.24177e-24
NC_022571.1\|WP_022749786.1\|4548285_4548960_+\|DUF2225-domain-containing-protein	gnl\|CDD\|378340	pfam09986, DUF2225, Uncharacterized protein conserved in bacteria (DUF2225). This domain, found in various hypothetical bacterial proteins, has no known function.	2.9763e-93
NC_022571.1\|WP_022749739.1\|4526380_4527949_-\|acyl-CoA:acetate/3-ketoacid-CoA-transferase	gnl\|CDD\|227016	COG4670, COG4670, Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism].	0
NC_022571.1\|WP_022749769.1\|4543969_4545304_-\|hypothetical-protein	gnl\|CDD\|226382	COG3864, COG3864, Uncharacterized protein conserved in bacteria [Function unknown].	1.35015e-69
NC_022571.1\|WP_022749782.1\|4547327_4548119_-\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	1.18253e-87
NC_022571.1\|WP_022749743.1\|4528059_4528836_-\|short-chain-enoyl-CoA-hydratase	gnl\|CDD\|180270	PRK05809, PRK05809, short-chain-enoyl-CoA hydratase.	1.20971e-134
NC_022571.1\|WP_022749794.1\|4551665_4552757_-\|glycosyl-hydrolase-53-family-protein	gnl\|CDD\|226385	COG3867, COG3867, Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism].	3.53845e-141
NC_022571.1\|WP_041716839.1\|4524043_4524391_-\|four-helix-bundle-copper-binding-protein	gnl\|CDD\|153434	cd08026, DUF326, Cysteine-rich 4 helical bundle widely conserved in bacteria. This functionally uncharacterized protein forms a 4-helical bundle with a bromodomain-like topology. It is present in major bacterial lineages and contains highly conserved cysteines in a repeated pattern, whose sidechains appear buried. Some family members have been (mis)annotated as putative ferredoxins.	1.42029e-26
NC_022571.1\|WP_022749765.1\|4543192_4543525_+\|HesB-like-protein	gnl\|CDD\|188182	TIGR01911, conserved_protein, HesB-like selenoprotein. This model represents a family of small proteins related to HesB and its close homologs, which are likely to be invovlved in iron-sulfur cluster assembly (See TIGR00049 and pfam01521). Several members are selenoproteins, with a TGA codon and Sec residue that aligns to the conserved Cys of the HesB domain. A variable Cys/Ser/Gly-rich C-terminal region is not included in the seed alignment and model. [Unknown function, General].	4.12127e-29
NC_022571.1\|WP_022749734.1\|4525154_4526294_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
NC_022571.1\|WP_022749719.1\|4523327_4523927_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|334163	pfam00589, Phage_integrase, Phage integrase family. Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.	8.32426e-29
NC_022571.1\|WP_022749755.1\|4539036_4540170_-\|response-regulator	gnl\|CDD\|226456	COG3947, COG3947, Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms].	3.10418e-84

>NC_022571.1|WP_169729035.1|4532616_4532913_-|hypothetical-protein
MEKGWHKSENGEWTYDGQDTVGQWFHLDANGKLTTGWLKDTDGNWYYLCDGSDYGALGVMKTGWQIIDSKWYYFNSNGTMASDTVIDGYALGNDGALI
>NC_022571.1|WP_140395238.1|4532304_4532439_+|sensor-histidine-kinase
MFERFYKGTKENYGLGLSISKNIIEKLNGQITAINLNSGASFII
>NC_022571.1|WP_022749747.1|4529757_4532208_+|leucine--tRNA-ligase
MANYGTKIDKKWQKIWGENETYKFNPENLDKKLYTLEMFSYPSGAQLHAGHWFNYGPTDSWARLKRMQGYNVFQPMGFDAFGLPAENYAIKTGIHPQDSTLKNIETMEKQLKSMGAMFNWENEVVTCLPDYYKWTQWLFLKLYEKGLAYRKKAPVNWCPSCNTVLANEQVVDGVCERCSTEVVKKDLTQWFFKITDYADELLDKLDGLDWPEKTKSMQKHWIGRSYGAEVTFKVKDSKLDFNVFTTRVDTLNGVTYVVLAPENKLVDELTLPEYKDAVEEYKEAASKQSEIERQSVSKEKTGIFTGSYAINPINGKEVPIWISDYVLSTYGTGCVMAVPAHDERDFAFATKFNLPIERVITDKDNSDPELPYCEYGVLVNSGKFDGLTTDEAKKKIVEELEKDKLGSMKVNFRLRDWLVSRQRYWGAPIPVIYCDDCGIVPVPEKDLPVKLPYDVEFTPDGKSPLSKSEEFINTTCPICGGHAKREADTLDTFVCSSWYYLRYADNKNEDAPFDPEKINKILPVDKYVGGPEHACMHLLYARFITKALRDMGYLNFGEPFLSLTHQGLILGPDGLKMSKSKGNTISPDDYIKEYGADVFRMYLMFGFGYTEGGAWNDDGIKSVGKFVDRIERTLETCINLFSSNENTKDSIDSAEKELNFWKHTAIKGVTEDGNKMQFNTAIARLMEFVNALNKYLQEDIKNVSFLKETITDFLKLLAPFAPHFAEEQWSLLGNTSTIFNERLPEFDPSALVKDEVEIAIQINGKIKAKINIPSNLDEDGIKKASLENKTVQENTEGKNIIKVIVIKGRLVNIVVK
>NC_022571.1|WP_022749743.1|4528059_4528836_-|short-chain-enoyl-CoA-hydratase
MENVIFKHENGIAEITINRPKSLNALNTQTLKELGQVINEISERKDIYTVIITGAGEKSFVAGADITEMKDKTAIEGREMAKLAQKVFSNIENMPQIVIAAVNGYALGGGCELSMACDIRLASTKAKFGQPEVGLGIIPGFAGTQRLPRLVGKGRAKELIFTTDMIDANEAYRIGLVNKIYEPNELIDKAKEMANKIMSKGTYAVSLAKSSINNGLNMDTESAYAFEADLFGLCFSTEDQTEGMSAFVGKRKASFKGC
>NC_022571.1|WP_022749739.1|4526380_4527949_-|acyl-CoA:acetate/3-ketoacid-CoA-transferase
MRKVNVLTSREAAEMVKDEDLLVTGGFVGSSAPETLSSAIEKLFLETGHPKNITLVHAAGQGDGKGKGADHYAHEGMTKRVVAGHWNLAPKLGKMAIENKIEAYNLPQGTISELFRDIAGKRVGTITHVGLNTFVDPRISGGKLNEKTTEDIVKLINIEGEEKLLYKSFPINVCFIRGSFADEYGNISLEREVASLEDTSIAQACKNNGGKVIVQVEKIVESGTLDPRLIKIPGIYVDGIVVSKPEEHEQSFGCEFNPAVTGDIRVPLSTMKKAPLNERKIIAKRCTMELKADTIVNLGIGIPEVISSVANEEGIGEYMTLTVEAGPIGGVPQGGTAFGASINPEAIIDQPYQFDFYDGGGVDIAFLGLAQVDEHGNLNVSKFGPRIAGCGGFINITQNAKKVLFCGTFTAGGLKISTGDGKLKIEQEGRAKKFVKNVEQITFSGDYARKMNQEVMYVTERAVFELRKDGLYLTEIAPGIDLQKDVLDLMEFKPKMDGVPKLMDEKIFYDKLMGLKNKSNES
>NC_022571.1|WP_022749734.1|4525154_4526294_-|acyl-CoA-dehydrogenase-family-protein
MDFNLTEQQQRIVQVVREFAENEIKPKVIEYDQSGEFPIDTYKKMGQLGLIGVPYPREYGGGNGDYLSYVLAVEEISKVSGSLGISYSVSTSLCAGGIMNAASEEQKKKYLPDVLSGKKFGSFGLTEPNAGSDAGGCITTADKDGDYYILNGAKCFITNGPLSETFLVFALTDKTKGSKGLSAFIVEKGFEGFSIGKVEDKCGIRSAQVSELIFENCKVPAENLVGIEGKGFGIAMKTLDGGRIGVAAQGLGIAEGAFDVAKQYMKDRQQFGKPLWKNQYLAFKMAELELEIEQAKYILYKAAMDKQEGRPYSVSAAKAKLACTDAAMHVTTEAVQMLGGNGYMKEYNVERMMRDAKITQIYEGTNEIQKLIISGSIFR
>NC_022571.1|WP_022749729.1|4524525_4524936_-|MarR-family-transcriptional-regulator
MELNECINFLLTKAQQVVFQSLKARLAKFDVTPVQYGILKCLWDEEYQTPKQISEILSLDSSTITGLLDRMENKGLIQRVPNKNDRRTLNVVITEEGLKYRKEIEQIIDDLNKDFLERFSEEDQKQLKNALRTIAR
>NC_022571.1|WP_041716839.1|4524043_4524391_-|four-helix-bundle-copper-binding-protein
MESLIPEGNPMQSCIDICVKCSQICQECLNLCLQESDVKERMNCIKSLQDCSEICSTSACFMSRSSGNIRELCNVCAIICQNCAAECRAFKDDHCPKCADMCHKCADECEKMINM
>NC_022571.1|WP_022749719.1|4523327_4523927_+|tyrosine-type-recombinase/integrase
MSKNTEPKIKYLTQKEALSLFNSIENSNSCHSIRDLAIFRLAYRCGLRASEISLLKLQDYNMLKGEIYCKRLKGSSNNTLRLDRKTKIVLDKYINENNITSDSQVIFTSQKNNPISRQTLDYLTKKYCSLARIEDKSKHHFHVLKHTTAVHLAECDMDIKELQWWLGHKSVSNTEIYFQFTTKQQDKMYEKLDGKNEMV
>NC_022571.1|WP_022749715.1|4522305_4523121_-|EAL-domain-containing-protein
MDRIERLQFSDRKSMIKDELKNVIEKNELYILYQPQINTLSNEITGIEALLRWDNSKLGSVSPVEFIPIAEDLDYIVDLGNWVMDKALRQAWVWKRKGYKFNTISVNVSPIQINKENFKKNLLNIINKYNIPRNFLEIEITEGIIIDINKEKIDMLTEIMNSGISIALDDFGTGYSSLSYLINIPVNTLKIDKIFIDNINSDKSKILIKGIVSLSKSLKYKIIVEGVETKEQLELLTNIGCNTIQGFYFSEPLSENEMENLLKINGGVNNI
>NC_022571.1|WP_022749755.1|4539036_4540170_-|response-regulator
MKVILVDDDKAMILILKRIMNKIEGVEIVNTFNSSINVLEFIKDNCIDMVFLDISMPGENGMELARNIYHMSPSTDIVFITSHREYALDAFEIYAFDYIIKPVLKERVERTIKRAFEKRSLLIKKIPEKEKNISVYLLGGIDVSSKSLGTVKWMSAKSMELFIYLLLNRGRNISKNVIIEDVFQGMPLKNAENYLKTSVYQIRKAFEPHVSNSILILKNGYYKLECSEFYVDCMDFEKSVGRIKEINEENIKDALDTEKIFIGELLGDRIYYWSISENEKYLNLYLNLAIKLVKYLLNNRDLNNASYILKKIIKLDALNEEANCLLMRLFEAQKDKNSLIKHFQDYERMIKKEFGVNPGCEIINFYEKLLKSFSEHR
>NC_022571.1|WP_022749764.1|4542234_4542981_-|methyltransferase
MKPYNKEFVFQVMKKYNELINEGTSGNYRIVKNVVEENLQGYMYENKEQYDISVIQLLKDNVSLMRLSPKEIESSYETIKFAKGKVGIVGLGIGYVVQEIAKKNSVEEVTVYEISEDVIELYNQNFTKNEKIKIIKGDAFKAENQKFDFFYVDIYEYKLTSKVVKDYKIFNELHEIEEYSFWGLEHFLLSCKYEDIVWVYIPENWISMSKKIYESLDSSGYIKTYRPLEENKVREILMQFKEVLNADM
>NC_022571.1|WP_022749765.1|4543192_4543525_+|HesB-like-protein
MKNITISEEAYNEFKAFLEENNISDFNIRINFAGFACSGPIFNISVSEATDDDEIEKINDISFIVEKTLIDQFGGFIILSTEENEGNGLSLKPVITPEGGCGGSCSGCHH
>NC_022571.1|WP_022749769.1|4543969_4545304_-|hypothetical-protein
MDFNEKKEQVLKEIYLLDTHNQFNNSHKRQFFDLVEDVILYLLQSEDAFFGQFMLRIKRGIRFDLKVPIATIPQRDGFNMYFNPVLFLNCTKKEMAALFKHEIYHIMSSHFQRERKMKQSLNKEAVSVALDISINQYIKDLPAYSKKLESVNMEYKIILRENRSIEEYAEEIYKSIKSRINKNKISKDNDSKSEIDMTRAHELWEEIDISEEDIENLTKKTALSSYNKSTPEGLQKIIKAYEEKPEIPWQVVLKSILPTMKSGYKKTITRRNRRQPERLDLRGRLPENETEVIVAIDISASMKDDDLHKILVEILSITSNTTNKITIIECDNEIRNIYKLRSERDIKKRSKNNGSTEFTPVFKYIIDNNLRNVVLIYFTDGVGEKELGVKPINKKTLWVISGNEELSLNNSYGEIKRINKERKQIIEGNVGLQMVNEVIHEWAR
>NC_022571.1|WP_022749773.1|4545357_4546440_-|AAA-family-ATPase
MNYSECLSTVDLIIESNDVPLIIGESGVGKTSLVKYIAKNNGYYLVTIDANLLKEGEIGGLPVVENRVTIYATHHKLTEIDRALKNDENANVILFIDELNRCDHAVAQELMNLILNREINGYVLDERVKVIAAMNPSNKNDGFYNSQYEVVDMDPAQEDRFVWVELDSDIKEWIKWAMSDNGNINEHIIEFLSTFPEYLHTPNTDETIKATPRSWERVSKAYNVYLNNKQKYPMNSFLNVVRGNVGANIANDFANFLINLKKPLIKVQDIFTNEILSFELKEKIEKENHSRLYILIKNALKYLEEIPTEKNINLFSELLNLYPRDLRLGIMKEIKRDYKDKIYENLLDNDMFLDAFFNIF
>NC_022571.1|WP_022749777.1|4546457_4547237_-|hypothetical-protein
MEKENILLKLKSNPEYIKELSEADEELKLFIVKNNGNNIKYIKNPSKEVQKEAIKNTPLSIQYIENVNEEIGILCVRTLWNSLELINNPSETIIEEAVQTKGWAIQFVKNPSEKLQILAVSKDYDAIKYITNPSEIVQLKAIENYYAAIRFIKNPTLKAKIKSIKSNGEAINYISNYDLDELKLFISENINVVKYIYESVDVETVVEVLMEKVKDETIEKKYIEDFLELEILEMDKINFIREYGSKNAKKILVDYKLSM
>NC_022571.1|WP_022749782.1|4547327_4548119_-|GTP-pyrophosphokinase-family-protein
MAINDWKNFLMPYEQAVDELKVKLRSIRKEYRRKNEYSPIEFVTGRVKEVSSMLEKANKFEIPIDRVKYELEDIAGIRIMCQFVDDIDIVVELLRGRKDMQILYEKDYVRNVKESGYRSYHMIIKYPVNMAEGPVEILAEFQIRTLAMNFWATIEHSLNYKYKRHIPEQIKEKLKRSADAAFRLDEEMLEIKDEIKDAQKLFEVKSHLISNIMNSLLTLISLGKEAEVARYQKTLNKLIEEGEVWELNSLLFSVKREIEKYKE
>NC_022571.1|WP_022749786.1|4548285_4548960_+|DUF2225-domain-containing-protein
MHDINILDHLFDKHITCPVCNSTFTTKTVKAKSPRIMSKDSDFFIRYKEINPYFYDVCICNSCGYAAMRSDFEKIRSYRKELVFSNITPKWQARQYPDILDEQLAIERYKLALLNAMLTDCPDSTKAMISLRIAWMYRLLNDNSQELSFMKQSLDGFIDAYTKELLPIYGLKRDSLTYLLGELNRKLGKDEEALLWYSKTIVNTNASFRIKEMARVGKSLIKNE
>NC_022571.1|WP_022749790.1|4548990_4549932_+|methyl-accepting-chemotaxis-sensory-transducer
MSIFKKSNKEIIAPTVSVSTNADQHSINKKDISKEVNILKNQTSNLDSSIKNISSSISSLTKSTQSQCSEIHTAKNILSDFRNNMENLAINITNVHIKVLDTDKLADTGLDSITHLDTSLNDLESAFTVSTSTVNSLVSKLESVNSITDSISQIASQTNLLSLNAAIEAARAGEAGKGFSVVAGEVRKLAENSKLAVQSITSILEEIKQDILKASNAMNSGNSALTIQHNSLEDAKNTFSDIKTSIEDATDEITTCIVNLTTASEAKDNVISSVDNIANLYSEHESVVKEVATSIDTQASEIKQLNKSISNLS
>NC_022571.1|WP_022749794.1|4551665_4552757_-|glycosyl-hydrolase-53-family-protein
MFKRSIKAILLGFMCTTITLGLGFTAAPTTVQAATTFAKGADIGWLNQLEDKGIKWQNDKGVQQDALQILKDHGINAVRLRVFVNPPSNYQWTKKDGTTCFLGYSDTNAAVYMAQRAKKLGMKVMIDFHYSDHFADPAYQDKPAQWANDSFDQLKNDVYSHTHYVMSALANAGIYPDWVQVGNETNTGMLWPDGSNYNYNKWAQLINSGYDAVKSVSSSSKVIIHLASGANNSLYRGVFDGLKSAGAKYDVIGMSYYPYWDGVDYTKNINSLAYNLNDMASRYNKEVMICEVGGPQNNPTQTYNIIKAAINKVQSVPNGKGIGVFYWEPEANSSVLPDSYPLGACNKVSENTLKFTSAIDAFK

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Crispr_ID: NC_022571_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022571_7

4652295-4652387

Orphan

Consensus_repeat	Method
TTTATTACATATATAGTTATATATGTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022571_7

>merge|NC_022571|7|4652295-4652387|CRISPRCasFinder
TTTATTACATATATAGTTATATATGTATGACGTTGCAACTAGTGTAAAAGTCGAATTAATTGCACGTTTATTACATATATCGTTATATATGTA

>NC_022571|7|6|4652295-4652387|CRISPRCasFinder
TTTATTACATATATAGTTATATATGTA	TGACGTTGCAACTAGTGTAAAAGTCGAATTAATTGCACG
TTTATTACATATATCGTTATATATGTA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022571.1\|WP_022750072.1\|4655384_4657631_+\|DNRLRE-domain-containing-protein	unknown	unknown	gnl\|CDD\|100796
NC_022571.1\|WP_022750028.1\|4637597_4640108_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
NC_022571.1\|WP_022750065.1\|4652593_4653733_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|131032
NC_022571.1\|WP_022750091.1\|4665426_4667055_-\|cadherin-like-beta-sandwich-domain-containing-protein	unknown	unknown	gnl\|CDD\|227588
NC_022571.1\|WP_022750095.1\|4667435_4669553_-\|toxin-A	unknown	unknown	gnl\|CDD\|227588
NC_022571.1\|WP_022750055.1\|4649555_4650152_+\|DUF4489-domain-containing-protein	unknown	unknown	gnl\|CDD\|379710
NC_022571.1\|WP_022750033.1\|4640396_4640681_+\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022750060.1\|4650536_4652276_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224152
NC_022571.1\|WP_022750067.1\|4654281_4655070_-\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022750047.1\|4646579_4648253_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224117
NC_022571.1\|WP_022750041.1\|4644539_4646006_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225926
NC_022571.1\|WP_022750039.1\|4642179_4643775_-\|peptide-chain-release-factor-3	unknown	unknown	gnl\|CDD\|179105
NC_022571.1\|WP_022750087.1\|4661962_4664857_-\|Ig-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|227588
NC_022571.1\|WP_022750083.1\|4660819_4661866_-\|InlB-B-repeat-containing-protein	unknown	unknown	gnl\|CDD\|227588
NC_022571.1\|WP_022750076.1\|4658068_4659043_-\|glycerophosphoryl-diester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176506
NC_022571.1\|WP_022750045.1\|4646219_4646489_-\|DUF3343-domain-containing-protein	unknown	unknown	gnl\|CDD\|378728
NC_022571.1\|WP_022750037.1\|4640936_4641899_+\|DNRLRE-domain-containing-protein	unknown	unknown	gnl\|CDD\|366248
NC_022571.1\|WP_022750099.1\|4669779_4670187_-\|DUF86-domain-containing-protein	unknown	unknown	gnl\|CDD\|366864
NC_022571.1\|WP_022750051.1\|4648504_4649281_+\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022750081.1\|4659239_4660388_+\|cadherin-like-beta-sandwich-domain-containing-protein	unknown	unknown	gnl\|CDD\|227588

Protein	Function_ID	Function_description	E-value
NC_022571.1\|WP_022750072.1\|4655384_4657631_+\|DNRLRE-domain-containing-protein	gnl\|CDD\|100796	PRK01156, PRK01156, chromosome segregation protein; Provisional.	0.000198564
NC_022571.1\|WP_022750028.1\|4637597_4640108_-\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	3.35346e-17
NC_022571.1\|WP_022750065.1\|4652593_4653733_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|131032	TIGR01977, am_tr_V_EF2568, cysteine desulfurase family protein. This model describes a subfamily of probable pyridoxal phosphate-dependent enzymes in the aminotransferase class V family. Related families contain members active as cysteine desulfurases, selenocysteine lyases, or both. The members of this family form a distinct clade and all are shorter at the N-terminus. The function of this subfamily is unknown. [Unknown function, Enzymes of unknown specificity].	3.83093e-176
NC_022571.1\|WP_022750091.1\|4665426_4667055_-\|cadherin-like-beta-sandwich-domain-containing-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.82118e-24
NC_022571.1\|WP_022750095.1\|4667435_4669553_-\|toxin-A	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.59115e-32
NC_022571.1\|WP_022750055.1\|4649555_4650152_+\|DUF4489-domain-containing-protein	gnl\|CDD\|379710	pfam14879, DUF4489, Domain of unknown function (DUF4489).	1.04972e-27
NC_022571.1\|WP_022750060.1\|4650536_4652276_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|224152	COG1231, COG1231, Monoamine oxidase [Amino acid transport and metabolism].	4.99921e-47
NC_022571.1\|WP_022750099.1\|4669779_4670187_-\|DUF86-domain-containing-protein	gnl\|CDD\|366864	pfam01934, DUF86, Protein of unknown function DUF86. The function of members of this family is unknown.	5.26086e-23
NC_022571.1\|WP_022750047.1\|4646579_4648253_-\|hypothetical-protein	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	1.59881e-14
NC_022571.1\|WP_022750041.1\|4644539_4646006_-\|hypothetical-protein	gnl\|CDD\|225926	COG3391, COG3391, Uncharacterized conserved protein [Function unknown].	2.31431e-07
NC_022571.1\|WP_022750039.1\|4642179_4643775_-\|peptide-chain-release-factor-3	gnl\|CDD\|179105	PRK00741, prfC, peptide chain release factor 3; Provisional.	0
NC_022571.1\|WP_022750087.1\|4661962_4664857_-\|Ig-like-domain-containing-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	3.30639e-26
NC_022571.1\|WP_022750083.1\|4660819_4661866_-\|InlB-B-repeat-containing-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	3.24197e-15
NC_022571.1\|WP_022750076.1\|4658068_4659043_-\|glycerophosphoryl-diester-phosphodiesterase	gnl\|CDD\|176506	cd08563, GDPD_TtGDE_like, Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase (TtGDE, EC 3.1.4.46) and its uncharacterized homologs. Members in this family show high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. Despite the fact that most of GDPD family members exist as the monomer, TtGDE can function as a dimeric unit. Its catalytic mechanism is based on the general base-acid catalysis, which is similar to that of phosphoinositide-specific phospholipases C (PI-PLCs, EC 3.1.4.11). A divalent metal cation is required for the enzyme activity of TtGDE.	7.07377e-82
NC_022571.1\|WP_022750045.1\|4646219_4646489_-\|DUF3343-domain-containing-protein	gnl\|CDD\|378728	pfam11823, DUF3343, Protein of unknown function (DUF3343). This family of proteins are functionally uncharacterized. This protein is found in bacteria and archaea. Proteins in this family are typically between 78 to 102 amino acids in length.	1.10583e-17
NC_022571.1\|WP_022750037.1\|4640936_4641899_+\|DNRLRE-domain-containing-protein	gnl\|CDD\|366248	pfam00688, TGFb_propeptide, TGF-beta propeptide. This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.	5.19731e-06
NC_022571.1\|WP_022750081.1\|4659239_4660388_+\|cadherin-like-beta-sandwich-domain-containing-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	2.81181e-14

>NC_022571.1|WP_022750060.1|4650536_4652276_-|FAD-dependent-oxidoreductase
MNSYKNTDSPYQIDNPSESERYTMLEYILKIQNRSDDLNNIIDLMSPPKDITNICKAGCAKNIKVAVIGAGEAGLAAAFELRKIGCNIVLFEASQRIGGRVYTHYFDRNRKYYGELGPMSIPISHETTWHYINLFKLETSPFVDYNYNSLFYVKDERAVNDASGISAKNNIYPKFNLSKIEGKKSWRELHERICKKYLSSFSAELRKELIQVKPEYSKNIKEIDKLNYRNAYENVDLSQDSISMLGYLDGKEQFFSLSLIEMLQKYYTADFEYNYRITDGMINLPQSLYEALCDKSEEGYKDINKEQLGKVEIKMGFPVSGIYDSSSKDKVILKYMDCRDNKETSEEFDYVICAIPFSSLRRIQIEPLFTNRKMQAISEMNYEIAHKIYLYLKNRFWEMGNASTKIVGGSSHTDLPLVSIYYPSDHAKAVANKYGKWILKHGASYKEAGALLAGYSWGQDAVRLGNENPELLLDDVMRYVERVHGLSLHYLDDKLIDYKSLIWSDVQYIWTGGALSKPGDKTLFSYNVTVPEMEDKVFFAGEHISQKHVSQQGALQSGMIAANEIAKRINDNAVNIKRS
>NC_022571.1|WP_022750055.1|4649555_4650152_+|DUF4489-domain-containing-protein
MNSLSHGNCGGTAGTGNICPNPCPPRFAACAAGAEELHPLPCPALLQCGEASNPRITSVFTPSTTTPSISLAEVEIDTTCLCFPNIKIEFSTLINADITGPAGSVTIRLSRSCNSGTNNCNGGTSKTLRSYTINLSGVGGSTITTPFSFVFCSENVPSKDCTYFVDIVSANPGPATGSFIEFTNTDIAALAVGCARIC
>NC_022571.1|WP_022750051.1|4648504_4649281_+|hypothetical-protein
MSVNLKRFSPRPGLVNKQGRLPDPSELVCIEVPKIFDQCLIKKCLVYGEGPDTNTTDFELRSNPLTDPKRYIGSRDFNLTLLSVDKIPLMGNPNFKKIIISYKISFCADYIDANGVNKSELYEINRTDVIGKFYCPDSIAQISASFVPGNQPQDLDSNIIKLEMVADALAGELLKDEAGKEVLDITLGYYIIVKCELIVQLLIPTYDYCPVPKAPCEEEPEEDPCEIFEKAPIPKFYPDQNLDPLFPDCDDGNRNEEM
>NC_022571.1|WP_022750047.1|4646579_4648253_-|hypothetical-protein
MNCVCPWIYVDYRNNIWDFFKNGNKELCYKIMYGEGKWSKESLIDKEIRGFAIYIEDDETIHIVYSNIKGELKYCTMKNKRWVGMTLYQIDVDEFEIQSLKIRIIRDEMHIFYLLIGKDGSDHGVLMHCIWNGRETKVNTLSDIILVPNINEHYMLNINENNDIDTFFITDEGDEISLNYCSFQNHIWSSVKRLYGIQGEEIDFEVLVDKEEINILNKSREDAIYFLDHVRIDKGGIIQEFRVYESSKELSEPLVFVKDRKLYSCWLEQGEILYSVFDNEKWRKAYHFDRGNELPVSRYNCFICSDGGSSIKAMKAYATDEPDLYLFVPSQFVINRKESLKDERIKVTEDLSSEGEEVQRLKLKLSRMKLEKKDLENKIDSLNMQLKKRLKSIHEYEEEFVRLVEQKRKADENYKVFLELQQNIQKKLENTNKQLLEERNVKASIENELKEYKEKNILIKQQVEMLSTENERLNKEIELEKENIQEKLEELNTNLLEERNIKASIESELKECKEENSLIKQQVEMMSEENKRLNKELEFERNQSIMERLLKRRSNGI
>NC_022571.1|WP_022750045.1|4646219_4646489_-|DUF3343-domain-containing-protein
MATEEYDYIMTFTSHNRALYMYQRLTGRNIKVKLVTAPNKINISCTQAVKFKEIDIEIIQTELKRNNIYPTATFKIIKDGKNETYELVN
>NC_022571.1|WP_022750041.1|4644539_4646006_-|hypothetical-protein
MVDKKEKMIYYVSNLGISTVSIIDGDGYHIIKEVEIGPRPQNIIVDESNNIYIASDRNGKVTVIHDLYDCIKTWDMPNNGNIQVDSIAHKIYVCNTDEVCIYDLRTGEKIGSLRGFIAADSIELNKNKKRLFVLDVLQNEIKVYDTSNLNLIKIYKDIGNSPKYILIEENENYIYIANREKIYILNIENENISFIDLEKRSIITSLEQSGTFLYVANDGLHRIEVIDTLKRKCIANITTTMQKVKRIRLSPDKKILLVIGQNIEGKGVINRIDVSGNVILDTFDLEKKNGIPYDIGVAIQRRLPKKEEALSIIDSEDTLKKENGTTILAKKVLSTYQEKIIFQDVSIKLTSEEEEIINIDEIRFKKCEIINETRNREIIDNRKEYSMLKYNFYIPYYIWYKDEHGRKYIDEGKIEGIQNATLYIPAYAEQQGVEFVVNSFTKLTSNPEIINNDLKFSVSVLISTRAIVDELVFIPFFKNCDVQACENK
>NC_022571.1|WP_022750039.1|4642179_4643775_-|peptide-chain-release-factor-3
MADYINEIEKRRTFAIISHPDAGKTTLTEKFLLYGGAIRLAGSVKARKASKHAVSDWMEIEKQRGISVTSSVMQFNYNDHCINILDTPGHQDFSEDTYRTLMAADSAVMVVDAAKGIEDQTRKLFHVASLREMPIFTFINKMDREAKDPFQLLDDIENELGIKTYPMNWPIGSGKEFKGVYERDNNRIIAFNGGNHGQNEVEAIEGSPDDPKFREILGDALHDKLMEDIELLDIAGDELDLDAVRRGELTPVFFGSALTNFGVEPFLEHFLEMTTSPLARNSSAGTIDPFEDKFSAFVFKIQANMNKAHRDRIAFMRICSGKFNKGEDVYHMQGGKKIKLAQPQQFMAQDREIVEEAYAGDIIGVFDPGIFSIGDTLCSPSKKFKFEGIPTFAPEHFARVRPVDTMKRKQFIKGVTQIAQEGAIQVFKETHIGMEEIIVGVVGVLQFEVLEYRLNNEYNVDVKMDRLDYRFVRWIENKDVDMDSLNLTSDTKKVKDLKDRNLLIFQNDWGISWALDHNKGLILSGVGKSED
>NC_022571.1|WP_022750037.1|4640936_4641899_+|DNRLRE-domain-containing-protein
MKSITIPAIKSLSVTNKYSDKSLNEDKIIVGSDSNYNYYSYLFWDISSIPANAIVHNAKLTLFKTDNFYYDTSKKFSISPLYEYFSTYTTYNNSPNYDHYTVINFYPLTDNISVTIDITTIVSSWVKNSLKNKGIILYGRNEDILTSFGSVKSSDSYLVPFIIVNYEPYSSNKCCKKECNNKCSQDCCCKKNCNGEYFKDDCCEKYIKICKKELEAILFKVCKEACGSNCNPYPPNTSITRTVRVTGTVAPASVYYIVVDLQVTRASSGQINHYYVSDEYDNSLNDTPLPIDKTYNIAVSPPIQSGDTEDVILYGSYKGF
>NC_022571.1|WP_022750033.1|4640396_4640681_+|hypothetical-protein
MASFDTPQNSTIQTIYATGTIPAHNDAGFIEIQAVASRNGGHETFYKTFQIAASATATTARAWSGAGNYQIVITPKLFGTQSVSSTTVVNSFKH
>NC_022571.1|WP_022750028.1|4637597_4640108_-|glycosyltransferase
MKDNLGNITKQSKDELINTTENLKEDVSGIVKDKIKLAFFVKMGLDSFLGDIIEGLSQEYEIKKIITIEYKQIEDGMQWADICWFEWCDELIAYGSKLELAKEKKIICRLHSYEAFTDYINNVNWSNVNRLIVVCEHIKSFIIKNFSIDEKIVSIIPNGIDEKRWRFKERENGFNIAYVGYINYKKGPMLLLHTFKAIYETDHRYKLYIAGIFQDNRYVLYYNQMIHEFGLENNVVYEGWQNDLDTWLEDKNAILCTSVLESQNMSVMQAMCKGIKPIIHNFVGARLIYPSQYVWNTITEAVEMISDKNYTSKVYRAFIKERYSLNDQLMKIKDLLISLPEKMSKGNLNYINSNDLKKSSDQVDLMKTKFTVNSDDITNTEALFDYLLSINDEESYMKYLSEWFIRSKYELTFKFNYYYGNMYRRFTSYSRFKYMQKNVYEEMDKIGGKILEENYLTYFNNKKISLKENKRKILFILNGLDIHQSVTQFFINYLQSSENIKHRYSVLSLLNKNEFNNSKESIDYFNKLNVNLFVPISNCIEDKIKEFYIYISEGNFDYVVYQSLYFAPIGVLLYPLLKKVCKIIGKIQFQQPEDYFDEKLDFCYTYIKKDNCCKNIFELISPINTELVDKNLDIRTLFNIDRKKKVVISIGRPIKYKNNEFWNFAIKLINEIHDICLVVFGGDYSEFKQYVPNKLIEEYKVIFAGFNLEASSYLKSCDFYLNSYPGGGYSLEEAYYAELPIITFCKEENDEAFNVMNASYMAPAYLYNNAKTIFPKTGDFDQLLSYSKKLIQDDSFRNTIKINRKIESNNLKFEYFVKEFEKYMDNIANNNGRNNK
>NC_022571.1|WP_022750065.1|4652593_4653733_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MIYLDNAATSFPKPSEVYEEVLKCMKNYAANPGRGSYEIAVKAASKIMETREEICNLFNIASLFNLIFTSNATEALNIGIKGILEKGDHVISTVIEHNSVLRPLHSLSEKGVDVTLISSDKAGYVSIKDIKDEIKKNTKMIIISHISNVLGSIQDIKNIGNLSKSNGIIFMVDASQSAGIIPIDVEREHIDLLAFSGHKGLLGPQGTGCLFIREGIKLKNFKEGGTGSNSHFMIQPDFLPDKFESGTLNTPGIAGLGEGVKFIKRIGIDSIQKYEEELTSYLLEEIKRLSYIKIYGSYSGNKRGPVVSFNIEGVDASIVGEELDKEGIAVRTGYHCAALIHDVIGTEYAGTVRVSPGYFNTFDDIEKLIVAIMRIYKVR
>NC_022571.1|WP_022750067.1|4654281_4655070_-|hypothetical-protein
MSINFKKFSPRPGIVNKQGRLPDPSELVCVEVPKVFDQCLIKRCLVYGEGPDTNTTDCELRSNPLKDPKRYIGSRDFNVKLISVEEIPNNGNPDFKKIILSYMISFYADYIDADGITKSELYEINRTDTIGKFYCPDSIAQISASCIHGNHDKDLDCNILKLEMVADALAGELLTDEGGNDVLDITLGYYIIVKCELVVQLLIPTYDYCPVPGEPCAEEEPEDVCVQFENAPVPKFYPDQNLRPLFSESDDDYEDDDYKDNN
>NC_022571.1|WP_022750072.1|4655384_4657631_+|DNRLRE-domain-containing-protein
MENSIKINCNDATYVCKFHSNTNFSKNNSLLVGGFTNKLSSFNLYRSILNFHIPDLKSDSIKEAYLFLFLEDIKYIHNGPENLILLGNSENIDIPNANWTNFPNNNFTKPVILSMPNTYVGSYLKVDVTSIIKSLVKFNMNYNIILTPPNKNSNAIFKLASSMSYTPPYLNIVTYAEDNIEFSEASEITENIEAIENDTYENTSENVTKNINDKSSVLDENQSDILPSIKNELINILLKKNIALNQSLINYITNEFNKQTSVLASIRSTINDADNFITIKKALDSHTNNLNNQNLILDFIKDKVNNNKSFVVTEDLLNKIVSTLNEQDSTLALIKDNQDSVATQNMLTSISDNLNEKISTLDENQSNILSYIKNDLINNLSEDNNTLNQNLIDDITNKFSDQASLLTSIENKISNYTIVDDLYKKHISLTQNLLQYLTSKFNDQTSILTSIEDEINNPKFINDLSQKHITLNQDLIDYINTKFNDQIPILTSIKDEVSNNESCIKIQNTLDSLSNNLESQSSILDSIKNKVNNNEAYSIAEDLLNKIVNTLTDQESSLTYIKDKVNSDEEFTNIKTILGSFSNNLENQSSILDCIKDKVNNNIPESLSEKLDTQNLKLDSYNDSFNDITKIFSDKLNSIDNKMDSIDNNLIDFKKDNTNNFDSYISPVSNDISELKNAISPLTENINMLKSNIDTLTNAINSKNNTIDENDKINSTNFNSINSQLSELSTNLKTLTETINSIANELLN
>NC_022571.1|WP_022750076.1|4658068_4659043_-|glycerophosphoryl-diester-phosphodiesterase
MKILNIAHRGYSGKFDENTMIAFRKAIEYKADGIETDVQLSKDGIPVIIHDETLDRTTDGHGFVKDYTLKELKEFRTKSVPRVQALKGEAIEGLQLIKEINSSKLGEYTLDEVEYFKNNNGEEIPTLRDLLELFSASDLKILNLELKNSISEYDELEEKVISMIDEYNLRDRVIISTFNHMSLVKIRELEKQEIEYMANQVETLKDSNSANYKNTNTKLKNDKTKPKSKIILGALTDSTLANVPKYLNDIDVECYHPCFYSILNKSYMKEIKNAGIKVNPYTVNEIEYMKMVIEAGADSIITNEVEKLNDVIKSFPNIDKQLGI
>NC_022571.1|WP_022750081.1|4659239_4660388_+|cadherin-like-beta-sandwich-domain-containing-protein
MNKNIKKLISFTIIFTAFSIFTPSTINILEQSAYAYSEYEINALSISSGYSIIPIYDSITYNKDYKIKNGDKIPSIIYSKISSDKASFKLNTLETNAVDIRAFSGNEKLNDIYGEITIPEGESKSIYIRLYNSKNASDNDYDSEYELIVERESSNSTDNDLDNESEDDTITLKDYDDIYLDNLILFDNNDNKIDFTFDKTNPISNINIDKSISCITVKAIPEEQVYNLLINDKHIKTSGNDKDKRLISLDEGKNIIKIRIVDSFNHKRREYFLVVTRGQDNSETYNNNNNNNNANTNLENAQGNYIKTNGNWQYKKADGTIAVGWTFINNEWYYFDSTGAMKTGWLKDTSGKWYYLKESGAMAKNTVIDGYTIVSDGSAINK
>NC_022571.1|WP_022750083.1|4660819_4661866_-|InlB-B-repeat-containing-protein
MKYIYLKRIIASCIISSTLLVMAPLGASAAWIGSYNEGWYYTEGYTYATGWRYINGTWYFFDDTGLMKTGWISSNGLWYYADLSGAMQKGVIQIEGKIYLFTDSGAMETGSAMINTKLYNFNEKGVCTSGEAPMPSRAFDYYGVDVRPYVPSQIVNSSDTKMNNDLPSDDANTVKTYKIQFKDDDGTSLKTKNVEEDKKVTLYEPTKSGYDFVEWNTKKNGDGTSYQYDDQITVKKDLTLYAQWNESTNTDTNNTSSDQNIPVTSIKVVSVGSKTTITLNSTLQMTRTVLPSNATTQNVTWSVEDGTGSATISSTGRLTPSKLGTVIVKATATDGSNVYGEIQITIVD
>NC_022571.1|WP_022750087.1|4661962_4664857_-|Ig-like-domain-containing-protein
MKRKLISKIIALSIVGTVSATIYPTRAFAAWTKDNQNNYYYTQGNSKLTGWNKINGSTYYFDEDGIMKTGWIKIDSSWYYLDNSGVLKRGWIYYNNNWYYSDASGVMQTGIIKIVGSTYIFTSNGIMQTGHAIINGTFYTLDNSGAVVSNSTPSANKQFDEYGKCVLDSGNSTSNIDAPNESKYNEEIVDQSKSDEDPNEGRKFKVTFKDSINGKDIEDKTVKYGRSIKLDEQDKDGYKFVEWNTMSSGKGKSYDSGDNVKIRSDLTLYAIWKQETDTKSVTSISISGDSQVEVGKKIQLSADILPSDATNTKVKWSVTNNGGSATIDNDGILTGATTGKVTVTATAADGSGLSSSKDVNIVAQKTLVTSITIGGDSVAITQDGGTLDIRTLLSVLPENASDKEVSWSVSKVAENTGDAIGNATISDSGVLTALGNGTVKVIATAKDGSGITGSKFVHISNQTVKLTSMAVRGKDNLKVVNVGDSTHNYSLQMYADLVPTNADISSTEWSVKDSTTSGSTMTGKAMINSSGVLTGTSPGTVTVAAKVTTKSGDVITGSQEINVVQLVTSIDVIGRSVTDQTTSSSITTNGGTLQMEATATPTNANTKDVTWSVVENDAKGTTTDKATISKSGILTATKNGEVLVQATATDGSGVVGSKVITISNQLIKVSKLTIDGLDNVEIGSDTISSPITLKMTAVTTPQVVSDNSVEWSVKEMSSSGPVDTDKATINQNGLLTAKSPGKVVIIVKAKDGSNTIATKEVEIIRKVESLVVLGANSSKKVATNGQLQMNAFVLPSDAKDQTVKWLVVQATTDEINNNSSKLTLNPGLASIEESTGILTGIANGEVKVIAISNYDNSIKGQLLVDVVVPVTSIQVQSSSQVITAGEQLQMSADGLSDATDKVVTWSIQGISGDTGQVSINNNTGELTTTSNITQKTVVTVIATAHDGFGACGTATITINPKKTT
>NC_022571.1|WP_022750091.1|4665426_4667055_-|cadherin-like-beta-sandwich-domain-containing-protein
MNKRIRRIIAVVLAVSAFSTIEPTKYMNITGITKAYASSTVIDNFQVNKAATDNELNLYEDEDYEDTTNFKASTDTYYVKTSSSSINFTFDTNSNYVTKVFKDDSKTGTPFDSGEEINLDKGTNTLYVRTYKESKFDKNNVKTNVIEEYKIVVERKTNSTNDVQLSKISLDYGDISFSKSQTSYDVDVNSSVDQIEITAKPSKKSYTVKIAGDEVTEDDDYQETVDLRKGANEIEINVTDDDGNENTYTLNIYRGGKSNTTTDNSDIDTTQDKIYLKDLKLNNGDVELDYNKQVTKYNVNVDSSVNKLTIKAEPQDDNDTVKVNGGKVDSDYEKTVNLDDNSTKEIQVKVKNSDGEQRIYTLNVTRGTVSQNSTTNNTSTDAANNTSTNTTSNTTTNDTNTNNNSTNQTTSNNTVVSKWVKDTVSDKWKYYDDKGDQVKGKWFYYINDNHWYYLDDQGNMKTGWLSKDYKWYYLDENGIMQIGWVNLSGTWYYLNADGSMRTGWLQEGTKKYYLNSNGAMQTGTATINGKSYTFDTAGAMSN
>NC_022571.1|WP_022750095.1|4667435_4669553_-|toxin-A
MIRRINKIVALVLVSTGISSAIPNNIFSQTANAAESNQSVINIDTQKNTVAMESQDQALKTVVKAMIPSKTGYSTSVISEFKECGSVAYTLDDATALSIGNTLKSNISQMIAGVNKVKNKGTEMKVKGQATSNNDMIQSGTDLESSATTVLEELNQANSMSDSQLVQMIESQAKNVTVYQYRELKSDDGLTASSPTTIQAEGFVVGGILGIALDPQDTYNAETRIATYNSSTLIENLTLNNNGTYGKSIDLNSSTNKVVCDGLHINVIDSQNNALYVINNPAYNMFKQSKSLYTDEDKRLNILNFPSEVNNLKGYATDISFNTGTQSIQTTILGLLLNLKNSSTTDKKTYKYVAPVDSPEAEMLNVVVSKLGLNDLAKQLVENQMKGSTFVMIPDVKTDITNKVNNAIDKINNTVEDITDAMKDLSDAMEDLNDSLNDKNNDVNKAWDKVFDRFDNDPGWAKKDGYWYYYDKDGISSKGAQTIDGKTYYFNRIDGAMETGWQIVNNKKCYFDKDKGYELFTQWVQDGDDWYFVDSSGAVKKSDWITSGGNYYYVKADGKMTKDWLKVDDNWYFFNSDGSMASSTWKWSDNKWYYLKENGAAANDWLQIGDNWYCFKDSSGELQTGWFRNNGNWYCAGDNGVMKTGWAYSSDGWCYLDDSTGKMKKNEWANINGKWYYFNINGTMVTGSRYINGTKYTFNSDGTME
>NC_022571.1|WP_022750099.1|4669779_4670187_-|DUF86-domain-containing-protein
MGKDVILNKIETIERCVNRINEVYDNNPENLNDYTKQDSIILNIQRACEASIDLAMHIVSEKKLGVPQNSRDSFEALNHNNIIDNELNKKMKSMVGFRNIAVHDYRAINLKVVQIIIESHLKDFEEYIYQINKLL

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Crispr_ID: NC_022571_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022571_8

4733675-4733770

Orphan

Consensus_repeat	Method
TAGATCCTTCTTCAGGTGCTATGAAAACAGGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022571_8

>merge|NC_022571|8|4733675-4733770|CRISPRCasFinder
TAGATCCTTCTTCAGGTGCTATGAAAACAGGATGGGCAAACAATAATGGAACTTGGTATTACCTAGACCCTTCTTCAGGTGCTATGAAAACAGGAT

>NC_022571|8|7|4733675-4733770|CRISPRCasFinder
TAGATCCTTCTTCAGGTGCTATGAAAACAGGAT	GGGCAAACAATAATGGAACTTGGTATTACC
TAGACCCTTCTTCAGGTGCTATGAAAACAGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022571.1\|WP_144079390.1\|4732249_4732891_-\|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase	unknown	unknown	gnl\|CDD\|376775
NC_022571.1\|WP_022750230.1\|4723945_4725382_-\|flippase	unknown	unknown	gnl\|CDD\|240533
NC_022571.1\|WP_022750276.1\|4739421_4740513_+\|acyltransferase	unknown	unknown	gnl\|CDD\|376607
NC_022571.1\|WP_022750235.1\|4727016_4728117_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340847
NC_022571.1\|WP_022750222.1\|4721525_4722431_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl\|CDD\|130274
NC_022571.1\|WP_022750280.1\|4740716_4741325_-\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022750226.1\|4722531_4723746_-\|polysaccharide-pyruvyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|377253
NC_022571.1\|WP_022750272.1\|4737842_4738817_-\|cell-wall-binding-repeat-containing-protein	unknown	unknown	gnl\|CDD\|227588
NC_022571.1\|WP_022750262.1\|4735007_4735775_-\|tyrosine-protein-phosphatase-YwqE	unknown	unknown	gnl\|CDD\|226870
NC_022571.1\|WP_022750291.1\|4747382_4747640_-\|hypothetical-protein	unknown	unknown	unknown
NC_022571.1\|WP_022750242.1\|4729081_4730320_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|274425
NC_022571.1\|WP_022750290.1\|4745329_4747045_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NC_022571.1\|WP_022750270.1\|4736548_4737229_-\|capsular-polysaccharide-biosynthesis-protein-YwqC	unknown	unknown	gnl\|CDD\|226453
NC_022571.1\|WP_022750283.1\|4741934_4743122_-\|YibE/F-family-protein	unknown	unknown	gnl\|CDD\|377940
NC_022571.1\|WP_022750239.1\|4728207_4729089_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|224137
NC_022571.1\|WP_022750234.1\|4725532_4726777_-\|O-antigen-ligase-family-protein	unknown	unknown	gnl\|CDD\|372600
NC_022571.1\|WP_022750266.1\|4735792_4736536_-\|CpsD/CapB-family-tyrosine-protein-kinase	unknown	unknown	gnl\|CDD\|349772
NC_022571.1\|WP_022750286.1\|4743267_4744926_-\|metallophosphoesterase-family-protein	unknown	unknown	gnl\|CDD\|277318
NC_022571.1\|WP_022750249.1\|4731132_4732179_-\|mannose-1-phosphate-guanylyltransferase	unknown	unknown	gnl\|CDD\|223906
NC_022571.1\|WP_022750245.1\|4730364_4731102_-\|WecB/TagA/CpsF-family-glycosyltransferase	unknown	unknown	gnl\|CDD\|224833

Protein	Function_ID	Function_description	E-value
NC_022571.1\|WP_144079390.1\|4732249_4732891_-\|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase	gnl\|CDD\|376775	pfam02397, Bac_transf, Bacterial sugar transferase. This Pfam family represents a conserved region from a number of different bacterial sugar transferases, involved in diverse biosynthesis pathways.	4.89854e-98
NC_022571.1\|WP_022750230.1\|4723945_4725382_-\|flippase	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	7.39139e-58
NC_022571.1\|WP_022750276.1\|4739421_4740513_+\|acyltransferase	gnl\|CDD\|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	4.7368e-08
NC_022571.1\|WP_022750235.1\|4727016_4728117_-\|glycosyltransferase	gnl\|CDD\|340847	cd03820, GT4_AmsD-like, amylovoran biosynthesis glycosyltransferase AmsD and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.	1.19588e-28
NC_022571.1\|WP_022750222.1\|4721525_4722431_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl\|CDD\|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	7.50941e-176
NC_022571.1\|WP_022750290.1\|4745329_4747045_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.74162e-51
NC_022571.1\|WP_022750226.1\|4722531_4723746_-\|polysaccharide-pyruvyl-transferase-family-protein	gnl\|CDD\|377253	pfam04230, PS_pyruv_trans, Polysaccharide pyruvyl transferase. Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.	9.90238e-30
NC_022571.1\|WP_022750272.1\|4737842_4738817_-\|cell-wall-binding-repeat-containing-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	2.08281e-14
NC_022571.1\|WP_022750262.1\|4735007_4735775_-\|tyrosine-protein-phosphatase-YwqE	gnl\|CDD\|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	4.42365e-80
NC_022571.1\|WP_022750242.1\|4729081_4730320_-\|glycosyltransferase	gnl\|CDD\|274425	TIGR03087, stp1, sugar transferase, PEP-CTERM/EpsH1 system associated. Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.	1.94812e-34
NC_022571.1\|WP_022750270.1\|4736548_4737229_-\|capsular-polysaccharide-biosynthesis-protein-YwqC	gnl\|CDD\|226453	COG3944, COG3944, Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane].	5.58071e-56
NC_022571.1\|WP_022750283.1\|4741934_4743122_-\|YibE/F-family-protein	gnl\|CDD\|377940	pfam07907, YibE_F, YibE/F-like protein. The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE and YibF. Most of the members of this family are annotated as being putative membrane proteins, and in fact the sequences contain a high proportion of hydrophobic residues.	3.42785e-78
NC_022571.1\|WP_022750239.1\|4728207_4729089_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	9.66456e-64
NC_022571.1\|WP_022750234.1\|4725532_4726777_-\|O-antigen-ligase-family-protein	gnl\|CDD\|372600	pfam13425, O-antigen_lig, O-antigen ligase like membrane protein.	5.44312e-14
NC_022571.1\|WP_022750266.1\|4735792_4736536_-\|CpsD/CapB-family-tyrosine-protein-kinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	4.56987e-84
NC_022571.1\|WP_022750286.1\|4743267_4744926_-\|metallophosphoesterase-family-protein	gnl\|CDD\|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	4.29089e-08
NC_022571.1\|WP_022750249.1\|4731132_4732179_-\|mannose-1-phosphate-guanylyltransferase	gnl\|CDD\|223906	COG0836, {ManC}, Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane].	1.68241e-148
NC_022571.1\|WP_022750245.1\|4730364_4731102_-\|WecB/TagA/CpsF-family-glycosyltransferase	gnl\|CDD\|224833	COG1922, WecG, Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane].	1.16483e-93

>NC_022571.1|WP_144079390.1|4732249_4732891_-|exopolysaccharide-biosynthesis-polyprenyl-glycosylphosphotransferase
MEETLFKEQIESRKLYCFIKRVMDILGSAMGLVILSPILLVIGIIVKIESKGPLVFAQERVGLNGKRFKMYKFRSMVANAEELKSKLHDQNEMNGPMFKMKEDPRVTKVGKFIRRTSLDELPQLVNVLKGEMSLVGPRPSLPKEVEQFEDWMMTRFSVKPGLTCYWQVSGRNDIEFEDWMKLDAKYVSERSTLVDIKLILKTFGVLFGDEHAS
>NC_022571.1|WP_022750249.1|4731132_4732179_-|mannose-1-phosphate-guanylyltransferase
MLCALIMAGGKGTRFWPLSTEEKPKQFLNLIGDDTMIQMTVNRIKPIIPMERIFVCTGAMYVDLVKEQLPELPERNIIIEPEGRNTTPCIALSALVIDRYFKDSTMIVLPSDHLIKDEEKFRNIIEESEDFLENNEQAIITLGMKPDRPETGYGYIKYNNETSKNDAFNTFKVDKFVEKPNEEKAKEYLENGSYLWNGGMFLWKTSTIIDEIKKYSPLTYEAIHEIESIKEENLQKLIDEKYNKTESISIDYAVLEKSKNIYVVPSEIGWDDIGTWKSVERYKEKDINNNILDGNARVIESNSNIAINKGKRIVMIGIDDVMTLETEDSIYIVNKDYMDNLRDYKNIV
>NC_022571.1|WP_022750245.1|4730364_4731102_-|WecB/TagA/CpsF-family-glycosyltransferase
MSRIKFLNTEIDNVTMLEAINKIDEFVSKRKPSYVVTPNVDHIVKLEVDEEFKEVYREADLILTDGMPLIWISNFKSMPIKEKISGSDFFPEVCKLASEKGYKIFLLGAAEGVAAKAAENLKNKFEGLNIVGTYSPSYGFEDKQEEIEKIIDIITKSKPDILAVGLGAPKQEKFIHKFRDRLNIPVSLAIGASIDFEAGNIQRAPIFMQKCGLEWFYRLCKEPKRMFKRYLVDDLKIFKIALKYK
>NC_022571.1|WP_022750242.1|4729081_4730320_-|glycosyltransferase
MKILFITNLLPYPLDNGGKIKSYNTLEMLSEENDVDIFSFYESRKELDSLKYMKSKFNNVHIIEKPLTTSKNIKKMIFIAFRSLFNKLPFVLLKFKDNNMSQLLKKEISKNKYDLVYIDHLQLGVYWDILKMCNCPIYLDEHNCESQILKRKIKSGENILKNCFIRLEYKKLKNFEDKIVKKCDKVIVLSEEDKKCLMNGVDVNKNKFTVIPIPIQADFMKTIGSRINNKKTLNIMFLGTLTWFPNSQGIEWFVDKVIPKLEQTNSNYKLFIVGKDPSESLMNKCKQNNKIIVTGYVDDVNEYIEKCDIMIVPIFVGSGMRVKILEGLGKRIPIISTQIGAEGIDVENEKDILLAENEQEFINSIVKLTDNELYSSIQKSGRKLFDSKYSIEAVITNYKRLVLNDKELKKNE
>NC_022571.1|WP_022750239.1|4728207_4729089_-|glycosyltransferase-family-2-protein
MNNTPLVFIILVNYKGVDHTIECIKSLNEITYSNYKIIVVDNDSQDNSVNKLKEYKKNFILIENKINTGFAGGNNLGINYAIKNNADYVLLLNNDTTVEPNFLDELINKTSPEIGINIGKILFYYDKSMLWYAGGRINALKGCTDVNGFEKDNGQYDEEKYVTFASGCCMLISKEVLNKVGMLMEEYFLYFEDTDYCAKVLNNGYKILYCPKSVIYHKESVSTVKESFNFLYYITRNRLYFIKDNIKGINKILSFIYSFIFIFTKAIIKNQDKKPILCAYKDFFRKKKGKLII
>NC_022571.1|WP_022750235.1|4727016_4728117_-|glycosyltransferase
MRFVTMFPETKNIHLTKDVGMIPFIMYKKFGYDSTIVCYKNGKYDYLRDEVKGLKINFIKKYTGKSIIDGAIYLLGNAKKIDVLHLFHLGKREIVWINLYKILNKNGKVYLKFDADYKIKKAINPSMNTLKSKIKNITLRKCKLTSVETLNIYKFLREEWKINVEHIPNGFYDYGKKEIVQYTNKDNIILTVGRIGSYQKATEILLEGFRLASSGLNNWRLRIVGPIEESFKDYMNKFITKNPNLKEKIEFTGAIYNRKKLEEEYRKAKIFCLTSRYEGFPLVFLEAIKHGCYIISSDFDAAYDITNNEKYGDVFTIDDVNELSICLTKDCNQEQKLRENCYKIQEYNYEEFYWPIICEKIHHLIN
>NC_022571.1|WP_022750234.1|4725532_4726777_-|O-antigen-ligase-family-protein
MDKKLLKYIIIFNPFLDIIYSVISKTGVTLPINQVVRILIMAYLFFRFTNNKDKIFVILIAILFGIGEVTYIYTNGTSVFTDIQYITKILYFIIVIYAFRSILSKHILTIDEILNYIILSSCIIVASIILSVFGIGFHTYFDGRFGYKGFFTVQNAVTATLIVTTPLNIFLYEKFKYKKYLVSFILSAISLCLIGTKAGIVGGVGSIVVVYLIFLFKMKFTYIKIILGLFSIATIISFSYFKQELFINVYNVMVEKIYSWGENNVYSYIVSNRNLQVSYVEQYISTYYKQNPLLFFGIGFTNCNNILQLHSFDIIEMDFNGILYYSGIWIFIVIFSIITKKILVLLKYFFESKLSIQYYTLLLSIIGGTIHSFWGGHVIYEAMTSLYYGIALIIPAILYQDIKIERTACCKPID
>NC_022571.1|WP_022750230.1|4723945_4725382_-|flippase
MRNIKLNKVVRNFISLTFANVLGQVLMFISVVYTAKYFGPDNFGIINFSNTIITYFTALASFGLQSLCVLEIAKSKKNNDYKINTILSLKLILATIVYILVIILAIFINKSIVYKLNILFYGLSIFPNAIYVDWIFNANEEMQYNSRSIIIKNLVYSVVVIIALRFFNITNLYYLAVFMFLATLISSLYLLKIAKRHYNMNFKFIINFKEYKRLILNSWPFFFSGIFATINSTIATLMLGFMRTDYEIGIYNSVYKIVNVFIMIAGILFTPVYPSLIRYYNEKQIDKLSTLVNNLRKIVYIISIPILCVAFILNKEIILTLYGDKYKDAYIVLTILFIYVALLYIREIYGYELSAWNLQKKYMKVVLLSSIYNIISNFAFIKYYGIEGAAVNTLISEIINVVLMFKISRNVVKIKYENKFIAKILVSSLGMSVIILICKIVTYNAIILSIIGGGIYFCLLFITNTISISEIKENVLTK
>NC_022571.1|WP_022750226.1|4722531_4723746_-|polysaccharide-pyruvyl-transferase-family-protein
MKKIILAGASLNSGNRGVNALTRGQIMLICDKYGYDSEIEILSYTVKDEIINKIIYNNKEIIVKETPCSKNELIVAYIESIGFGENYILKKIKLADMVFDISEGDSFSDIYGTKRFIQHSIIKLIAINVKTKIVIMPQTLGPFNRNWVKIIARKILNKADKVFVRDEISKKVATEELQIQRDIKYIPDLAFYMKCDEKTFIDKFISDKKKIKVGINVSALLYNGGYTKNNMFNLKANYKKLVTSLIEKFANMNDVEVILIPHVMTKNFEVEDDFSVCKKIANDISKKIRTDIKTIDKYYREDEIKTIISGCDFFIGSRMHACIAAISTKVPTAPIAYSRKFIGIWEKIELGDCVLDPKNESENEIIEKIIKIYNNRSRIKEVLELQIPLLKSQIENIPYIIEQK
>NC_022571.1|WP_022750222.1|4721525_4722431_-|glucose-1-phosphate-thymidylyltransferase-RfbA
MKGIILAGGSGTRLYPVTKAMSKQMVPIYDKPMIYYPMSVLMLAGIKDILIISTPRDIVNFKELFKDGQELGLNIEYAIQENPNGLAEAFIIGEKFIGDDNVAMVLGDNIFYGQSFTEHLRKAASLENGAYVFGYYVQNPKAFGVVEFDSNNKVISLEEKPENPKSKYAVPGLYFYDNSVVEKAKSLRPSPRGELEITDLNKSYMQEGSLKVQLLGRGMAWLDTGTHASMLQASNFVEAVQNTQGTYIACLEEIAYRKGWITSKQVIELAKPLMKTGYGKYLMDIVDEVEKSKKEVAVTVK
>NC_022571.1|WP_022750262.1|4735007_4735775_-|tyrosine-protein-phosphatase-YwqE
MIDIHSHIIPGIDDGSKNMEMTLEMLIAAEKSGTKKIVATPHYLMEYGEAKINEVKDHVEKINSIVNDEGINIEVYAGQEVYFTHNIINDYLEGNIGTINDSRYMLIEFSMRNQEQNLFDTLYELQVRNIVPIIAHPERYKYIINKPSIINDFINEGYLFQMNAGSLEGVFGDSVRKTAEILITNGIYNFIGSDAHNTTTRSVGISEGVDLANAKNKINGELIGESSRRLILNEDIEFCGQKIKEKKSIFSFFGR
>NC_022571.1|WP_022750266.1|4735792_4736536_-|CpsD/CapB-family-tyrosine-protein-kinase
MFSAKKLENAVANQQYRGFVVEKKPKSIAAEAYRTLRTNIQYSSFDKEIRSIVVTSAEAAEGKSTVSGNLAISFAQNEKKVIIVDCDLRKPSVHKNFKISNLVGLSEVLIGKAKLEEVVQSRNEYLDMLPSGKIPPNPSEMLSSKAMVNLIEKLKETYDIIILDSAPLLAVTDAQILSKDVDGTILVTRAGRTKRESVIEAKNLLTKVGANIIGSVLHAVENTRGKYYYYYGSNEDGDETKTKKKHK
>NC_022571.1|WP_022750270.1|4736548_4737229_-|capsular-polysaccharide-biosynthesis-protein-YwqC
MNEEIVRLEDIVDILNKRWKMILSITVITTLIAGILSFFIIAPKYEASTKLFIGKENSQTQDKNYNNSDIQMYQQLLKTYAGVITTNDLVENAINNADLNVTSQEVLKNLTVTPSANTQILEIKYISKDKTLSRDLVDSITNQFIKESTELIPNGNVKVIESVKMPENPVSPNKKLNIAIGFLLGLMVSIGLAFLLEFVDNTFKTKEQVEQILGLPVVGAIPDDFN
>NC_022571.1|WP_022750272.1|4737842_4738817_-|cell-wall-binding-repeat-containing-protein
MNKKLKQLIAIALTVSSVAAFGPTNVFSLITPVSARTSVLDPDELKTLNITTSNGSNLKICSDSYDGKEVDISDIDPDSNKEFYAVLPTGNTKINVSADIKGKNYIAKIFTSKNENAKAYDPARPYDEGNDIYLTDDVTNLYIRIYRSQDDYDEVKDTDVTDCSNTYIVHIKKEEAFSKKYPANSDNDSQTNHEYKQSKDIYNNSNNIEKIIVPGSSQIEIKSSQWVKDALGWQYNGSDGTPVKNAWLLDNQTGKYYYVQTDGYMTTGWKYIDGNWYCFDNSGVMQTGWIQSSDGSWYYLYSSGKMAKDTTIDGYTLSYNGQMM
>NC_022571.1|WP_022750276.1|4739421_4740513_+|acyltransferase
MENLKFTRDDTSIAKGIAIICMFIHHLFTFPNRIKGSSEFISLFQFNGNNIEYWFGQYGRICVAMFLFFSGFGIYKQFAKNNAHVSSNVFKRLKNLYVNYWTVFIIFIPISFFTGYREFNLAEFFDNFVGYRSTYDGEWWFFELYVLVIATFPVTVKLIKNSSVTSFFKIMVLAVLSRTVYVSLKDVPLFNTFARTIFYSELNLLLTWLPCFLMGITFAKFDLFPKISQKFKDNKLDNIFVYLLICLVLMYVRFRNDDVIDFDYLIAPLYILCSVNIVKILKLNKLFVYLGKHSSNMWLVHSFFCYQYFQWWVYLPKISIFVLLWLIIITIATSIAIEFIKKQVTKLCSGEFKLSYMNRALRD
>NC_022571.1|WP_022750280.1|4740716_4741325_-|hypothetical-protein
MKKIRTRVITLCLSLGILAGTIGMPTAAFAATTDATYKVSNGITTDSPDSIKGTDGTSKDSIYGASLAASGGSSFSGSANFNANVNIDVLGIANRIISAINARNFNGQNAAFCKGLMESAFYAAHGQYNVVVMDLSQNYKHNISGVKYFATYQYGGTTFGVWVFSRQQPKGSYFENDGRRGWDHWACQGWQTQVNNVMWYNR
>NC_022571.1|WP_022750283.1|4741934_4743122_-|YibE/F-family-protein
MKLKLDRISAIKICSKIIIPIAVLVAYIVIAVNFSSHTPIYNPYSSGAGGEMHYEKGKVISIDEQVINPSGFSGLYIGRQMVNVLIESGQYKGQTFQVNNALNYDTNFILHNGQEIVVSVNTSTGDKSQINVYMFSPYRVVPLLVLIGIFIGAICLVGGWRGFHSVLGIIFTLTTVIFIFVPLLFYGISAVAATIFLVVITSCVTLFLVGGFDRKTLSAVLGTVAGVIVSVIIMLVFSKILGISGYTSSDTDALLNIAGQSKLQVKDLLFTGVIIASLGAVMDIAISIATSINELHKQKQNACFNELFRSGMNIGRDMMGTMSNTLILAFLGESIFSFILMYSYQVQFKQLFNSNGITIDIVNAVCGSLAVIFTVPIVSAIAAKLLQGKQSSDFI
>NC_022571.1|WP_022750286.1|4743267_4744926_-|metallophosphoesterase-family-protein
MKISKKAKFIIPIAVGTIIATTSCLHFVENVNAEVMDSSGIEGFSLPKVTGGYNINANVGSDPKELDFAWFTQSSGKTQIKIARTSDMNGTQFPNSADIHDATQSTVKVTQSIKQDCTVLPYTNGVGDPSNYRDNVFNGKSVSDTPTGEYSNKVTVKELTPNTKYSYSVSDGQGNWSPVYSISTLSTDKVSFAAFGDPQIGAFDNSKGTAKSSATGGHKNLNDDKTAWQNMLKLVNQNKDLNFLFTMGDQVNDYNYLIQPSNSSDGQWYQYRDFFNPDSAVNYIQSMPLAEFCGNHDHQMGEYYGYHYNQPNISKLGSTKYGNDGDYWFTAGPVLFLVLDANNYGTADHDQFIAQAIKANPNAKWKVATWHQSAYSEANHNTKNEIEDPALTIRNTWTKMMDKYNIDVVLQGHDHYYTRTAQMLNGNVVEPNTGTPETLKNIGNESAPGTTNPNATYARKEYPNSVTNPKGTVYFTLDTGTGSKYYDFNTGSNDTVGGSADHSFSVVGWQGYVPSYSYVSFTDNTFKIKTYATTDFKVENQSLIDSYTITKN
>NC_022571.1|WP_022750290.1|4745329_4747045_-|methyl-accepting-chemotaxis-protein
MKRSCKRLRNVKITRNIILIWIISLMSTVIIGVEGYSNTNKMYNITNNINSNVIPKLKDWGDVNGYMGVLRNTLTKIIDRPFDPKNEKTMLELNNNITTIMQRQVISSQGDEKEAELVKTAKEAYEHYYSFIPNIIEQRKQGLVPDTKITNEDMGVYGNALAKSITDLVDYQKNTANENSEQSKNVYHDSIIGFGIVFVLSILILTIISLIIIVAIRDLIKEFTNDLQILSEGDFTIEIDDSLTNEFGIMNNALKKTINSISHILKNIETESTSIHSQSSSLSMLAEQMNTSTQDISSAIDGVAKGSSSQASELVTMNELLNNFGVSLDEVGAIINKVNAHTKEVNVKAESSNNELAHIITSINNISNSVNDVGQKISDLTSSVKEINEITNLLNDIAEQTNLLALNAAIEAARAGESGKGFAIVAEEIGKLAEQSKHSSNGINELVKTIQSETDMVTMTANDANSELSKQVSVIDNSIKSFKDIIISIGNILPEMDDINSSISQINKKKENIMDVAENIAAVAEENCASAEEISATTQNMISSADEVEKSSQVLNNKTNSMIEQVNKFSL
>NC_022571.1|WP_022750291.1|4747382_4747640_-|hypothetical-protein
MNCKTVNKSKFKLMNYFTNKNNDYNKASKNITSIYKYIIGLWQAIFHRIDNDPNNYKKNYNYCDTSYNVTDRIELRLIASKKTFL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022571_3	3.11\|2253134\|36\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2253134-2253169	36	NC_022571.1	3308493-3308528	2	0.944

1. spacer 3.11|2253134|36|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to position: 3308493-3308528, mismatch: 2, identity: 0.944

ttaaataattattagaattagatatactactagttg	CRISPR spacer
ttaaataattattagaatcagatatactactggttg	Protospacer
******************.************.****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022571_4	4.14\|2818969\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2818969-2819004	36	LC519601	Cronobacter phage vB_CsaP_009 DNA, complete genome	75914-75949	7	0.806
NC_022571_4	4.19\|2819295\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819295-2819330	36	NC_008014	Lawsonia intracellularis PHE/MN1-00 plasmid 3, complete sequence	156164-156199	7	0.806
NC_022571_4	4.19\|2819295\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819295-2819330	36	NC_020130	Lawsonia intracellularis N343 plasmid 3, complete sequence	156186-156221	7	0.806
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	NZ_CP046706	Nostoc sp. ATCC 53789 plasmid pNsp_c, complete sequence	151973-152006	7	0.794
NC_022571_3	3.4\|2252677\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252677-2252711	35	NZ_CP040462	Enterococcus sp. M190262 plasmid pM190262, complete sequence	10539-10573	8	0.771
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	NZ_CP019876	Komagataeibacter nataicola strain RZS01 plasmid pKNA01, complete sequence	55275-55309	8	0.771
NC_022571_4	4.13\|2818904\|35\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2818904-2818938	35	NZ_CP033461	Brevibacillus laterosporus strain 1821L plasmid p1821L01, complete sequence	20689-20723	8	0.771
NC_022571_4	4.14\|2818969\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2818969-2819004	36	NZ_CP022092	Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed2, complete sequence	12923-12958	8	0.778
NC_022571_4	4.14\|2818969\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2818969-2819004	36	NZ_CP035295	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed1, complete sequence	36521-36556	8	0.778
NC_022571_4	4.14\|2818969\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2818969-2819004	36	NC_013378	Staphylococcus epidermidis plasmid SAP105B, complete sequence	5898-5933	8	0.778
NC_022571_4	4.15\|2819035\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819035-2819068	34	AP014229	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C90-MedDCM-OCT-S34-C72, * SEQUENCING IN PROGRESS *	5873-5906	8	0.765
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	MK764441	Flavobacterium phage FPSV-F12, complete genome	58378-58411	8	0.765
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	KU599886	Flavobacterium phage Fpv20, complete genome	47573-47606	8	0.765
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	NC_031931	Flavobacterium phage Fpv2, complete genome	47394-47427	8	0.765
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	KT876726	Flavobacterium phage FpV21, complete genome	47385-47418	8	0.765
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	KU599877	Flavobacterium phage Fpv1, complete genome	47419-47452	8	0.765
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	MK764449	Flavobacterium phage FPSV-S29, complete genome	47076-47109	8	0.765
NC_022571_4	4.30\|2820013\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2820013-2820048	36	MK268686	Enterococcus phage vB_EfaH_EF1TV, complete genome	25894-25929	8	0.778
NC_022571_4	4.30\|2820013\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2820013-2820048	36	MK721192	Enterococcus phage vB_EfaM_Ef2.3, complete genome	27729-27764	8	0.778
NC_022571_4	4.30\|2820013\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2820013-2820048	36	CAJDJZ010000002	Enterococcus phage vB_EfaH_149 genome assembly, contig: phage149-genome, whole genome shotgun sequence	130124-130159	8	0.778
NC_022571_4	4.30\|2820013\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2820013-2820048	36	AP018714	Enterococcus phage phiEF17H DNA, complete sequence	131430-131465	8	0.778
NC_022571_4	4.30\|2820013\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2820013-2820048	36	MK693030	Enterococcus phage vB_EfaM_Ef2.1, complete genome	25301-25336	8	0.778
NC_022571_4	4.30\|2820013\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2820013-2820048	36	CAJDJY010000002	Enterococcus phage 156 genome assembly, contig: phage156-genome, whole genome shotgun sequence	128974-129009	8	0.778
NC_022571_4	4.30\|2820013\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2820013-2820048	36	MN854830	Enterococcus phage PBEF129, complete genome	25198-25233	8	0.778
NC_022571_4	4.30\|2820013\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2820013-2820048	36	LR031359	Enterococcus phage 156, complete genome	128974-129009	8	0.778
NC_022571_4	4.30\|2820013\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2820013-2820048	36	KJ801817	Enterococcus phage ECP3, complete genome	109290-109325	8	0.778
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	NZ_CP041064	Bacillus megaterium strain KNU-01 plasmid pKNU_01_1, complete sequence	111993-112027	9	0.743
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	NZ_CP032530	Bacillus megaterium NCT-2 plasmid pNCT2_2, complete sequence	40546-40580	9	0.743
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	CP041518	Bacillus aryabhattai strain KNU10 plasmid unnamed2, complete sequence	78660-78694	9	0.743
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	NZ_CP018876	Bacillus megaterium strain JX285 plasmid 3, complete sequence	25302-25336	9	0.743
NC_022571_3	3.11\|2253134\|36\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2253134-2253169	36	MT774386	CrAssphage cr110_1, complete genome	72552-72587	9	0.75
NC_022571_3	3.11\|2253134\|36\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2253134-2253169	36	MT774383	CrAssphage cr11_1, complete genome	89075-89110	9	0.75
NC_022571_4	4.22\|2819490\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819490-2819525	36	NZ_CP014570	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp2, complete sequence	2519-2554	9	0.75
NC_022571_4	4.22\|2819490\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819490-2819525	36	KU878088	Bacillus phage AR9, complete genome	90297-90332	9	0.75
NC_022571_4	4.22\|2819490\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819490-2819525	36	MF360957	Bacillus virus PBS1, complete genome	600-635	9	0.75
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	MN693756	Marine virus AFVG_250M718, complete genome	30800-30833	9	0.735
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	MN694439	Marine virus AFVG_250M296, complete genome	29997-30030	9	0.735
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	MN693803	Marine virus AFVG_250M716, complete genome	6799-6832	9	0.735
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	MN694282	Marine virus AFVG_250M297, complete genome	30009-30042	9	0.735
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	MT701588	Klebsiella phage Metamorpho, complete genome	16877-16910	9	0.735
NC_022571_4	4.26\|2819752\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819752-2819785	34	MN694541	Marine virus AFVG_250M717, complete genome	30412-30445	9	0.735
NC_022571_8	8.1\|4733708\|30\|NC_022571\|CRISPRCasFinder	4733708-4733737	30	NC_010105	Enterobacteria phage JS98, complete genome	97411-97440	9	0.7
NC_022571_8	8.1\|4733708\|30\|NC_022571\|CRISPRCasFinder	4733708-4733737	30	MH791409	UNVERIFIED: Escherichia phage EcWhh-1, complete genome	159174-159203	9	0.7
NC_022571_8	8.1\|4733708\|30\|NC_022571\|CRISPRCasFinder	4733708-4733737	30	NC_012741	Enterobacteria phage JS10, complete genome	96487-96516	9	0.7
NC_022571_8	8.1\|4733708\|30\|NC_022571\|CRISPRCasFinder	4733708-4733737	30	MK310184	Phage NC-G, complete genome	40245-40274	9	0.7
NC_022571_8	8.1\|4733708\|30\|NC_022571\|CRISPRCasFinder	4733708-4733737	30	EU863409	Enterobacteria phage JS10, complete sequence	96487-96516	9	0.7
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	KF751797	Campylobacter phage CJIE4-5, complete genome	14225-14259	10	0.714
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	KF751794	Campylobacter phage CJIE4-2, complete genome	13978-14012	10	0.714
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	KF751795	Campylobacter phage CJIE4-3, complete genome	12306-12340	10	0.714
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	KF751796	Campylobacter phage CJIE4-4, complete genome	12344-12378	10	0.714
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	KF751793	Campylobacter phage CJIE4-1, complete genome	15252-15286	10	0.714
NC_022571_4	4.8\|2818578\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2818578-2818611	34	AP014235	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C93-MedDCM-OCT-S38-C9, * SEQUENCING IN PROGRESS *	7892-7925	10	0.706
NC_022571_4	4.14\|2818969\|36\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2818969-2819004	36	EF506570	Spiroplasma kunkelii virus SkV1_CR2-3x, complete genome	3059-3094	10	0.722
NC_022571_4	4.17\|2819164\|35\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819164-2819198	35	NC_018878	Bacillus thuringiensis Bt407 plasmid BTB_502p, complete sequence	129490-129524	10	0.714
NC_022571_4	4.17\|2819164\|35\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2819164-2819198	35	MN693272	Marine virus AFVG_25M206, complete genome	40569-40603	10	0.714
NC_022571_4	4.8\|2818578\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2818578-2818611	34	NZ_LR214952	Mycoplasma neurolyticum strain NCTC10166 plasmid 2	13682-13715	11	0.676
NC_022571_4	4.8\|2818578\|34\|NC_022571\|CRT,PILER-CR,CRISPRCasFinder	2818578-2818611	34	NZ_LR214954	Mycoplasma neurolyticum strain NCTC10166 plasmid 4	8556-8589	11	0.676
NC_022571_1	1.1\|148480\|40\|NC_022571\|CRISPRCasFinder	148480-148519	40	NZ_CP035512	Haematobacter massiliensis strain OT1 plasmid pOT1-2, complete sequence	14175-14214	12	0.7
NC_022571_3	3.7\|2252872\|35\|NC_022571\|PILER-CR,CRISPRCasFinder,CRT	2252872-2252906	35	NZ_CP053469	Fusobacterium nucleatum strain Fn12230 plasmid unnamed, complete sequence	30024-30058	12	0.657

1. spacer 4.14|2818969|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to LC519601 (Cronobacter phage vB_CsaP_009 DNA, complete genome) position: , mismatch: 7, identity: 0.806

aactatattaatttcatcatcttttaaatcaatgta	CRISPR spacer
atcactatcaatttcatcatcttttaaaacaatatc	Protospacer
* *  ***.******************* ****.*

2. spacer 4.19|2819295|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NC_008014 (Lawsonia intracellularis PHE/MN1-00 plasmid 3, complete sequence) position: , mismatch: 7, identity: 0.806

ttttactgatacaaacactaaaactgatactaaaac	CRISPR spacer
tgatgctggtacaaacactgaaactgatactaaagg	Protospacer
*  *.***.**********.**************.

3. spacer 4.19|2819295|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NC_020130 (Lawsonia intracellularis N343 plasmid 3, complete sequence) position: , mismatch: 7, identity: 0.806

ttttactgatacaaacactaaaactgatactaaaac	CRISPR spacer
tgatgctggtacaaacactgaaactgatactaaagg	Protospacer
*  *.***.**********.**************.

4. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP046706 (Nostoc sp. ATCC 53789 plasmid pNsp_c, complete sequence) position: , mismatch: 7, identity: 0.794

atttagaaatagataaaactcaagagaatagaat--	CRISPR spacer
gtttagaaatatataaaattca--agatttgaattt	Protospacer
.********** ******.***  *** * ****

5. spacer 3.4|2252677|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040462 (Enterococcus sp. M190262 plasmid pM190262, complete sequence) position: , mismatch: 8, identity: 0.771

gctagt--aatgaagatgatgatgtagacactactaa	CRISPR spacer
--caattaaatgaagtttatgatgtagacactacaat	Protospacer
  .*.*  ******* * **************** *

6. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019876 (Komagataeibacter nataicola strain RZS01 plasmid pKNA01, complete sequence) position: , mismatch: 8, identity: 0.771

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
gaacctttttctttattatttttagttcgttggct	Protospacer
*** ********** ********** *.    ***

7. spacer 4.13|2818904|35|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP033461 (Brevibacillus laterosporus strain 1821L plasmid p1821L01, complete sequence) position: , mismatch: 8, identity: 0.771

aaagtattt---aaaatagagaggtgataaatgatgag	CRISPR spacer
---ctatatcgaaaagtagaaaggtgataaatgatgaa	Protospacer
    *** *   ***.****.****************.

8. spacer 4.14|2818969|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP022092 (Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.778

-aactatattaatttcatcatcttttaaatcaatgta	CRISPR spacer
taaagat-ttaatttcttcatcatttaaatcaattct	Protospacer
 **  ** ******** ***** *********** .

9. spacer 4.14|2818969|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP035295 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.778

-aactatattaatttcatcatcttttaaatcaatgta	CRISPR spacer
taaagat-ttaatttcttcatcatttaaatcaattct	Protospacer
 **  ** ******** ***** *********** .

10. spacer 4.14|2818969|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NC_013378 (Staphylococcus epidermidis plasmid SAP105B, complete sequence) position: , mismatch: 8, identity: 0.778

-aactatattaatttcatcatcttttaaatcaatgta	CRISPR spacer
taaagat-ttaatttcttcatcatttaaatcaattct	Protospacer
 **  ** ******** ***** *********** .

11. spacer 4.15|2819035|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to AP014229 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C90-MedDCM-OCT-S34-C72, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.765

cgaaaactgataatccaagtgaccctgctccttc	CRISPR spacer
ccgaaactgataattcaagtgaccttggttcagc	Protospacer
* .***********.*********.** *.*  *

12. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MK764441 (Flavobacterium phage FPSV-F12, complete genome) position: , mismatch: 8, identity: 0.765

atttagaaatagataaaactcaagagaatagaat	CRISPR spacer
atttagaaatggaaaaaactcaagcacaaaacat	Protospacer
**********.** ********** . * *. **

13. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to KU599886 (Flavobacterium phage Fpv20, complete genome) position: , mismatch: 8, identity: 0.765

atttagaaatagataaaactcaagagaatagaat	CRISPR spacer
atttagaaatggaaaaaactcaagcacaaaacat	Protospacer
**********.** ********** . * *. **

14. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NC_031931 (Flavobacterium phage Fpv2, complete genome) position: , mismatch: 8, identity: 0.765

atttagaaatagataaaactcaagagaatagaat	CRISPR spacer
atttagaaatggaaaaaactcaagcacaaaacat	Protospacer
**********.** ********** . * *. **

15. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to KT876726 (Flavobacterium phage FpV21, complete genome) position: , mismatch: 8, identity: 0.765

atttagaaatagataaaactcaagagaatagaat	CRISPR spacer
atttagaaatggaaaaaactcaagcacaaaacat	Protospacer
**********.** ********** . * *. **

16. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to KU599877 (Flavobacterium phage Fpv1, complete genome) position: , mismatch: 8, identity: 0.765

atttagaaatagataaaactcaagagaatagaat	CRISPR spacer
atttagaaatggaaaaaactcaagcacaaaacat	Protospacer
**********.** ********** . * *. **

17. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MK764449 (Flavobacterium phage FPSV-S29, complete genome) position: , mismatch: 8, identity: 0.765

atttagaaatagataaaactcaagagaatagaat	CRISPR spacer
atttagaaatggaaaaaactcaagcacaaaacat	Protospacer
**********.** ********** . * *. **

18. spacer 4.30|2820013|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MK268686 (Enterococcus phage vB_EfaH_EF1TV, complete genome) position: , mismatch: 8, identity: 0.778

ggttaatcctaaatcaattgcccattgttccatcaa	CRISPR spacer
tttaaatgctaaatcaattacccattgttccatttc	Protospacer
  * *** ***********.*************.

19. spacer 4.30|2820013|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MK721192 (Enterococcus phage vB_EfaM_Ef2.3, complete genome) position: , mismatch: 8, identity: 0.778

ggttaatcctaaatcaattgcccattgttccatcaa	CRISPR spacer
tttaaatgctaaatcaattacccattgttccatttc	Protospacer
  * *** ***********.*************.

20. spacer 4.30|2820013|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to CAJDJZ010000002 (Enterococcus phage vB_EfaH_149 genome assembly, contig: phage149-genome, whole genome shotgun sequence) position: , mismatch: 8, identity: 0.778

ggttaatcctaaatcaattgcccattgttccatcaa	CRISPR spacer
tttaaatgctaaatcaattacccattgttccatttc	Protospacer
  * *** ***********.*************.

21. spacer 4.30|2820013|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to AP018714 (Enterococcus phage phiEF17H DNA, complete sequence) position: , mismatch: 8, identity: 0.778

ggttaatcctaaatcaattgcccattgttccatcaa	CRISPR spacer
tttaaatgctaaatcaattacccattgttccatttc	Protospacer
  * *** ***********.*************.

22. spacer 4.30|2820013|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MK693030 (Enterococcus phage vB_EfaM_Ef2.1, complete genome) position: , mismatch: 8, identity: 0.778

ggttaatcctaaatcaattgcccattgttccatcaa	CRISPR spacer
tttaaatgctaaatcaattacccattgttccatttc	Protospacer
  * *** ***********.*************.

23. spacer 4.30|2820013|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to CAJDJY010000002 (Enterococcus phage 156 genome assembly, contig: phage156-genome, whole genome shotgun sequence) position: , mismatch: 8, identity: 0.778

ggttaatcctaaatcaattgcccattgttccatcaa	CRISPR spacer
tttaaatgctaaatcaattacccattgttccatttc	Protospacer
  * *** ***********.*************.

24. spacer 4.30|2820013|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MN854830 (Enterococcus phage PBEF129, complete genome) position: , mismatch: 8, identity: 0.778

ggttaatcctaaatcaattgcccattgttccatcaa	CRISPR spacer
tttaaatgctaaatcaattacccattgttccatttc	Protospacer
  * *** ***********.*************.

25. spacer 4.30|2820013|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to LR031359 (Enterococcus phage 156, complete genome) position: , mismatch: 8, identity: 0.778

ggttaatcctaaatcaattgcccattgttccatcaa	CRISPR spacer
tttaaatgctaaatcaattacccattgttccatttc	Protospacer
  * *** ***********.*************.

26. spacer 4.30|2820013|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to KJ801817 (Enterococcus phage ECP3, complete genome) position: , mismatch: 8, identity: 0.778

ggttaatcctaaatcaattgcccattgttccatcaa	CRISPR spacer
tttaaatgctaaatcaattacccattgttccatttc	Protospacer
  * *** ***********.*************.

27. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP041064 (Bacillus megaterium strain KNU-01 plasmid pKNU_01_1, complete sequence) position: , mismatch: 9, identity: 0.743

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
aatgctttcacttttttatttttagatttcaatcc	Protospacer
.* .****. ******************* *  *.

28. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032530 (Bacillus megaterium NCT-2 plasmid pNCT2_2, complete sequence) position: , mismatch: 9, identity: 0.743

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
aatgctttcacttttttatttttagatttcaatcc	Protospacer
.* .****. ******************* *  *.

29. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to CP041518 (Bacillus aryabhattai strain KNU10 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.743

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
aatgctttcacttttttatttttagatttcaatcc	Protospacer
.* .****. ******************* *  *.

30. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018876 (Bacillus megaterium strain JX285 plasmid 3, complete sequence) position: , mismatch: 9, identity: 0.743

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
aatgctttcacttttttatttttagatttcaatcc	Protospacer
.* .****. ******************* *  *.

31. spacer 3.11|2253134|36|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to MT774386 (CrAssphage cr110_1, complete genome) position: , mismatch: 9, identity: 0.75

ttaaataattattagaattagatatactactagttg	CRISPR spacer
ttaaataattattaaaattagatataagaaagcccg	Protospacer
**************.***********  *  . ..*

32. spacer 3.11|2253134|36|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to MT774383 (CrAssphage cr11_1, complete genome) position: , mismatch: 9, identity: 0.75

ttaaataattattagaattagatatactactagttg	CRISPR spacer
ttaaataattattaaaattagatataagaaagcccg	Protospacer
**************.***********  *  . ..*

33. spacer 4.22|2819490|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP014570 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp2, complete sequence) position: , mismatch: 9, identity: 0.75

gcaaatttaatttaaggaggaaattattattatgtt	CRISPR spacer
tcaaatttaatttaaggagaaaattatgttgaaaag	Protospacer
 ******************.*******  * * .

34. spacer 4.22|2819490|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to KU878088 (Bacillus phage AR9, complete genome) position: , mismatch: 9, identity: 0.75

gcaaatttaatttaaggaggaaattattattatgtt	CRISPR spacer
cttcatcttctttaaggaaaaaattattattatgtt	Protospacer
 .  **.*  ********..****************

35. spacer 4.22|2819490|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MF360957 (Bacillus virus PBS1, complete genome) position: , mismatch: 9, identity: 0.75

gcaaatttaatttaaggaggaaattattattatgtt	CRISPR spacer
cttcatcttctttaaggaaaaaattattattatgtt	Protospacer
 .  **.*  ********..****************

36. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MN693756 (Marine virus AFVG_250M718, complete genome) position: , mismatch: 9, identity: 0.735

atttagaaat---agataaaactcaagagaatagaat	CRISPR spacer
---taatgactgaagataaaacaaaagagaatagaat	Protospacer
   **. .*.   *********  *************

37. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MN694439 (Marine virus AFVG_250M296, complete genome) position: , mismatch: 9, identity: 0.735

atttagaaat---agataaaactcaagagaatagaat	CRISPR spacer
---taatgactgaagataaaacaaaagagaatagaat	Protospacer
   **. .*.   *********  *************

38. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MN693803 (Marine virus AFVG_250M716, complete genome) position: , mismatch: 9, identity: 0.735

atttagaaat---agataaaactcaagagaatagaat	CRISPR spacer
---taatgactgaagataaaacaaaagagaatagaat	Protospacer
   **. .*.   *********  *************

39. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MN694282 (Marine virus AFVG_250M297, complete genome) position: , mismatch: 9, identity: 0.735

atttagaaat---agataaaactcaagagaatagaat	CRISPR spacer
---taatgactgaagataaaacaaaagagaatagaat	Protospacer
   **. .*.   *********  *************

40. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MT701588 (Klebsiella phage Metamorpho, complete genome) position: , mismatch: 9, identity: 0.735

atttagaaatagataaaactcaagagaatagaat	CRISPR spacer
attcagaaatagataaacctcaagcagatgataa	Protospacer
***.************* ****** ..**.. *

41. spacer 4.26|2819752|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MN694541 (Marine virus AFVG_250M717, complete genome) position: , mismatch: 9, identity: 0.735

atttagaaat---agataaaactcaagagaatagaat	CRISPR spacer
---taatgactgaagataaaacaaaagagaatagaat	Protospacer
   **. .*.   *********  *************

42. spacer 8.1|4733708|30|NC_022571|CRISPRCasFinder matches to NC_010105 (Enterobacteria phage JS98, complete genome) position: , mismatch: 9, identity: 0.7

gggcaaacaataatggaacttggtattacc	CRISPR spacer
aagcaaacaataatggaatttcgtaccttt	Protospacer
..****************.** ***.. ..

43. spacer 8.1|4733708|30|NC_022571|CRISPRCasFinder matches to MH791409 (UNVERIFIED: Escherichia phage EcWhh-1, complete genome) position: , mismatch: 9, identity: 0.7

gggcaaacaataatggaacttggtattacc	CRISPR spacer
aagcaaacaataatggaatttcgtaccttt	Protospacer
..****************.** ***.. ..

44. spacer 8.1|4733708|30|NC_022571|CRISPRCasFinder matches to NC_012741 (Enterobacteria phage JS10, complete genome) position: , mismatch: 9, identity: 0.7

gggcaaacaataatggaacttggtattacc	CRISPR spacer
aagcaaacaataatggaatttcgtaccttt	Protospacer
..****************.** ***.. ..

45. spacer 8.1|4733708|30|NC_022571|CRISPRCasFinder matches to MK310184 (Phage NC-G, complete genome) position: , mismatch: 9, identity: 0.7

gggcaaacaataatggaacttggtattacc	CRISPR spacer
aagcaaacaataatggaatttcgtaccttt	Protospacer
..****************.** ***.. ..

46. spacer 8.1|4733708|30|NC_022571|CRISPRCasFinder matches to EU863409 (Enterobacteria phage JS10, complete sequence) position: , mismatch: 9, identity: 0.7

gggcaaacaataatggaacttggtattacc	CRISPR spacer
aagcaaacaataatggaatttcgtaccttt	Protospacer
..****************.** ***.. ..

47. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to KF751797 (Campylobacter phage CJIE4-5, complete genome) position: , mismatch: 10, identity: 0.714

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
tttattttttgtattttatttttagatttaaactc	Protospacer
   *.***** * ******************  ..

48. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to KF751794 (Campylobacter phage CJIE4-2, complete genome) position: , mismatch: 10, identity: 0.714

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
tttattttttgtattttatttttagatttaaactc	Protospacer
   *.***** * ******************  ..

49. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to KF751795 (Campylobacter phage CJIE4-3, complete genome) position: , mismatch: 10, identity: 0.714

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
tttattttttgtattttatttttagatttaaactc	Protospacer
   *.***** * ******************  ..

50. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to KF751796 (Campylobacter phage CJIE4-4, complete genome) position: , mismatch: 10, identity: 0.714

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
tttattttttgtattttatttttagatttaaactc	Protospacer
   *.***** * ******************  ..

51. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to KF751793 (Campylobacter phage CJIE4-1, complete genome) position: , mismatch: 10, identity: 0.714

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
tttattttttgtattttatttttagatttaaactc	Protospacer
   *.***** * ******************  ..

52. spacer 4.8|2818578|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to AP014235 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C93-MedDCM-OCT-S38-C9, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 10, identity: 0.706

tttgatttgttttagtcttcttttttttatacaa	CRISPR spacer
aatgatttctttttgtcttcttttttcttttgtc	Protospacer
  ****** **** ************.* *

53. spacer 4.14|2818969|36|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to EF506570 (Spiroplasma kunkelii virus SkV1_CR2-3x, complete genome) position: , mismatch: 10, identity: 0.722

aactatattaatttcatcatcttttaaatcaatgta-	CRISPR spacer
tttattaataatttcatcattttttaaatc-acgcac	Protospacer
  .  ** ************.********* *.*.*

54. spacer 4.17|2819164|35|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NC_018878 (Bacillus thuringiensis Bt407 plasmid BTB_502p, complete sequence) position: , mismatch: 10, identity: 0.714

ccaacagttaatttttccatcttgaccttttatat	CRISPR spacer
ctttcctacaatttttccatcttcagcttttatac	Protospacer
*.  *   .************** * ********.

55. spacer 4.17|2819164|35|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to MN693272 (Marine virus AFVG_25M206, complete genome) position: , mismatch: 10, identity: 0.714

ccaacagttaatttttccatcttgaccttttatat	CRISPR spacer
ttgatacagaatttttccaccttgaccttgtataa	Protospacer
...*.*   **********.********* ****

56. spacer 4.8|2818578|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NZ_LR214952 (Mycoplasma neurolyticum strain NCTC10166 plasmid 2) position: , mismatch: 11, identity: 0.676

tttgatttgttttagtcttcttttttttatacaa	CRISPR spacer
acctatttgttttagtcttttttcttttgttttt	Protospacer
 .. ***************.***.****.* .

57. spacer 4.8|2818578|34|NC_022571|CRT,PILER-CR,CRISPRCasFinder matches to NZ_LR214954 (Mycoplasma neurolyticum strain NCTC10166 plasmid 4) position: , mismatch: 11, identity: 0.676

tttgatttgttttagtcttcttttttttatacaa	CRISPR spacer
acctatttgttttagtcttttttcttttgttttt	Protospacer
 .. ***************.***.****.* .

58. spacer 1.1|148480|40|NC_022571|CRISPRCasFinder matches to NZ_CP035512 (Haematobacter massiliensis strain OT1 plasmid pOT1-2, complete sequence) position: , mismatch: 12, identity: 0.7

caggttcaagtcctgtctccgcaaccattatatataaaat	CRISPR spacer
caggttcaaatcctgtccccgcaaccatctttacttgctc	Protospacer
*********.*******.**********. *   * .  .

59. spacer 3.7|2252872|35|NC_022571|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053469 (Fusobacterium nucleatum strain Fn12230 plasmid unnamed, complete sequence) position: , mismatch: 12, identity: 0.657

gaaactttttcttttttatttttagatttaacgct	CRISPR spacer
tcttctttttcttttttattttaatatttcttttc	Protospacer
    ****************** * ****  . ..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

427132 : 498542

Clostridium_phage(14.29%)

integrase,protease,tRNA,coat,transposase

attL 425409:425468|attR 470664:470745

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
425409:425468	attL	NA	NA	NA	NA
WP_022743731.1\|427132_428332_-\|integrase	site-specific integrase	A0A0A8WIF9	Clostridium_phage	1.2e-21	26.0
WP_022743732.1\|428603_429092_-	hypothetical protein	A0A0A7RVV2	Clostridium_phage	7.3e-31	49.0
WP_022743733.1\|429187_429541_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_022743734.1\|429761_429953_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_041716018.1\|429970_430165_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_022743736.1\|430214_431375_+	phage replisome organizer N-terminal domain-containing protein	V5UQV4	Oenococcus_phage	4.9e-33	56.9
WP_022743738.1\|432176_432419_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A2I7SC16	Paenibacillus_phage	5.4e-11	45.9
WP_022743740.1\|433287_433506_-	DUF2922 domain-containing protein	NA	NA	NA	NA
WP_022743741.1\|433547_433772_-	DUF1659 domain-containing protein	NA	NA	NA	NA
WP_022743742.1\|434457_435531_+	galactose ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_022743743.1\|435815_436949_+	DUF2156 domain-containing protein	NA	NA	NA	NA
WP_077393748.1\|437207_437552_+	VTT domain-containing protein	NA	NA	NA	NA
WP_022743746.1\|438014_438956_+	glycoside hydrolase family 25 protein	NA	NA	NA	NA
WP_022743747.1\|439157_439982_-	TerC/Alx family metal homeostasis membrane protein	A0A291LBC5	Escherichia_phage	6.6e-32	37.3
WP_022743748.1\|440651_441506_+\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
WP_022743749.1\|442525_443434_+	hypothetical protein	A0A173GBF6	Staphylococcus_phage	3.3e-08	39.3
WP_041716020.1\|444036_444276_-	hypothetical protein	NA	NA	NA	NA
WP_022743751.1\|444266_444449_-	hypothetical protein	NA	NA	NA	NA
WP_022743752.1\|444610_444775_+	hypothetical protein	NA	NA	NA	NA
WP_041716430.1\|444897_445287_+	hypothetical protein	NA	NA	NA	NA
WP_022743754.1\|446892_447507_+	hypothetical protein	NA	NA	NA	NA
WP_022743757.1\|448693_448894_-	YvrJ family protein	NA	NA	NA	NA
WP_022743758.1\|448986_449478_-	hypothetical protein	NA	NA	NA	NA
WP_022743759.1\|449818_450061_+	hypothetical protein	NA	NA	NA	NA
WP_022743760.1\|450153_450741_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_022743761.1\|450903_451800_+	N-acetylmuramoyl-L-alanine amidase	NA	NA	NA	NA
WP_022743762.1\|452064_455373_+	DEAD/DEAH box helicase family protein	NA	NA	NA	NA
WP_022743763.1\|455393_456950_+	N-6 DNA methylase	J7I0U9	Acinetobacter_phage	1.8e-30	29.0
WP_041716431.1\|456984_458154_+	restriction endonuclease subunit S	A0A1V0SLK8	Klosneuvirus	6.5e-17	24.1
WP_022743765.1\|458229_459210_+\|integrase	tyrosine-type recombinase/integrase	A0A2H4JAA2	uncultured_Caudovirales_phage	3.4e-35	28.1
WP_022743766.1\|459258_459819_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_022743767.1\|460004_460550_+	hypothetical protein	NA	NA	NA	NA
WP_022743768.1\|460550_462716_+	AAA family ATPase	NA	NA	NA	NA
WP_022743769.1\|462696_462885_+	hypothetical protein	NA	NA	NA	NA
WP_022743471.1\|463179_464418_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	2.5e-51	51.1
WP_022743770.1\|464641_465160_-	helix-turn-helix transcriptional regulator	A0A2H4PQQ2	Staphylococcus_phage	3.3e-05	41.1
WP_022743771.1\|465572_467288_+	putative DNA binding domain-containing protein	NA	NA	NA	NA
WP_077393829.1\|468448_469834_+	MATE family efflux transporter	NA	NA	NA	NA
WP_022743775.1\|471280_473332_+	M13 family metallopeptidase	E3T4I7	Cafeteria_roenbergensis_virus	1.2e-82	33.6
470664:470745	attR	NA	NA	NA	NA
WP_022743776.1\|478832_479780_+	polysaccharide deacetylase	NA	NA	NA	NA
WP_022743777.1\|480133_481513_+	TldD/PmbA family protein	NA	NA	NA	NA
WP_022743778.1\|481516_482860_+	TldD/PmbA family protein	NA	NA	NA	NA
WP_022743779.1\|483315_485187_-	LTA synthase family protein	NA	NA	NA	NA
WP_022743780.1\|485379_485949_+	sulfurtransferase-like selenium metabolism protein YedF	NA	NA	NA	NA
WP_022743781.1\|486020_486980_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_022743782.1\|487172_487751_-	lipolytic protein G-D-S-L family	NA	NA	NA	NA
WP_022743783.1\|487844_488531_-	RusA family crossover junction endodeoxyribonuclease	NA	NA	NA	NA
WP_022743784.1\|489209_490229_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	1.2e-64	40.7
WP_022743785.1\|490237_491248_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_022743786.1\|491694_492921_+	trypsin-like peptidase domain-containing protein	A0A1B1IT49	uncultured_Mediterranean_phage	2.8e-18	25.8
WP_022743787.1\|493208_493580_+	carboxypeptidase regulatory-like domain-containing protein	NA	NA	NA	NA
WP_022743788.1\|493848_494988_+	carbohydrate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_022743789.1\|495522_496650_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_022743790.1\|496774_497791_+\|coat	CotS family spore coat protein	NA	NA	NA	NA
WP_140395219.1\|497762_498542_+\|coat	spore coat protein	NA	NA	NA	NA

DBSCAN-SWA_2

685595 : 698862

Caulobacter_phage(44.44%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_022743953.1\|685595_686951_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	8.0e-59	32.8
WP_022743956.1\|688090_688633_+\|transposase	transposase zinc-binding domain-containing protein	NA	NA	NA	NA
WP_022743957.1\|689323_690691_+	TerD family protein	K4JRX3	Caulobacter_phage	2.4e-23	35.3
WP_022743958.1\|690841_691420_+	TerD family protein	K4JRX3	Caulobacter_phage	2.2e-26	38.4
WP_022743959.1\|691463_692060_+	TerD family protein	K4JRX3	Caulobacter_phage	5.1e-26	34.3
WP_022743960.1\|692090_692669_+	TerD family protein	K4JRX3	Caulobacter_phage	7.6e-27	39.6
WP_022743961.1\|692731_693454_+	TerC family protein	A0A068EP98	Bacillus_phage	4.2e-51	52.3
WP_022743962.1\|693563_694160_+	TerD family protein	NA	NA	NA	NA
WP_022743963.1\|694169_694343_+	DUF4236 domain-containing protein	NA	NA	NA	NA
WP_022743964.1\|694362_695661_+	VWA domain-containing protein	I7HXI7	Enterobacteria_phage	5.3e-20	28.3
WP_022743965.1\|695719_697264_+	Hsp70 family protein	A0A0N9QXN8	Chrysochromulina_ericina_virus	8.5e-65	33.6
WP_022743966.1\|697269_698862_+	Hsp70 family protein	A0A1V0SC87	Catovirus	1.2e-61	33.0

DBSCAN-SWA_3

956776 : 1017681

Erysipelothrix_phage(30.77%)

holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_022744172.1\|956776_957550_+\|holin	phosphocholine cytidylyltransferase family protein	NA	NA	NA	NA
WP_022744173.1\|957551_958850_+	phosphoenolpyruvate mutase	A0A2H4N7Y0	Lake_Baikal_phage	8.3e-05	32.0
WP_022744174.1\|958969_960103_+	phosphonopyruvate decarboxylase	NA	NA	NA	NA
WP_022744175.1\|960144_961266_+	2-aminoethylphosphonate--pyruvate transaminase	NA	NA	NA	NA
WP_022744176.1\|961912_962473_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_022744177.1\|962877_963432_+	accessory gene regulator B family protein	NA	NA	NA	NA
WP_022744179.1\|963649_964900_+	sensor histidine kinase	NA	NA	NA	NA
WP_022744180.1\|965149_966040_+	sulfide/dihydroorotate dehydrogenase-like FAD/NAD-binding protein	NA	NA	NA	NA
WP_022744181.1\|966039_967434_+	NADPH-dependent glutamate synthase	NA	NA	NA	NA
WP_022744182.1\|967935_968661_+	membrane protein	NA	NA	NA	NA
WP_022744183.1\|968766_969447_+	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	3.0e-54	50.0
WP_144079372.1\|969419_970334_+\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	4.0e-78	63.4
WP_052334784.1\|971019_971913_+	hypothetical protein	NA	NA	NA	NA
WP_158380588.1\|971900_972614_+	restriction endonuclease	NA	NA	NA	NA
WP_022744185.1\|972667_972892_+	hypothetical protein	NA	NA	NA	NA
WP_022744187.1\|973671_974061_+	hypothetical protein	NA	NA	NA	NA
WP_022744188.1\|974143_975172_+	WYL domain-containing protein	NA	NA	NA	NA
WP_022744189.1\|975261_977766_+	50S ribosome-binding GTPase	NA	NA	NA	NA
WP_022744190.1\|977758_979465_+	50S ribosome-binding GTPase	NA	NA	NA	NA
WP_022744191.1\|979770_980466_+	hypothetical protein	NA	NA	NA	NA
WP_022744192.1\|980618_980816_+	hypothetical protein	NA	NA	NA	NA
WP_022744193.1\|981007_981946_-	FAD:protein FMN transferase	NA	NA	NA	NA
WP_022744194.1\|981938_982886_-	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	2.0e-69	44.2
WP_022744195.1\|983058_983658_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	8.1e-64	60.8
WP_022744196.1\|983672_986096_+	flavocytochrome c	A0A2P0ZL82	Lactobacillus_phage	4.3e-289	61.7
WP_022744197.1\|987319_988180_+	hypothetical protein	NA	NA	NA	NA
WP_022744198.1\|988214_989126_+	SMEK domain-containing protein	NA	NA	NA	NA
WP_022744199.1\|989475_989613_+	hypothetical protein	NA	NA	NA	NA
WP_022743471.1\|989838_991077_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	2.5e-51	51.1
WP_022744200.1\|991269_992175_-	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_022744201.1\|992186_993413_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_022744202.1\|993405_993999_-	N-6 DNA methylase	NA	NA	NA	NA
WP_022744203.1\|994151_995420_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_022744205.1\|996568_999580_-	type I restriction endonuclease subunit R	NA	NA	NA	NA
WP_022744206.1\|999660_999858_-	helix-turn-helix domain-containing protein	A0A2K5B263	Erysipelothrix_phage	1.9e-17	68.9
WP_022744207.1\|999896_1001738_-	AAA family ATPase	NA	NA	NA	NA
WP_022744208.1\|1001742_1002192_-	hypothetical protein	NA	NA	NA	NA
WP_022744209.1\|1002184_1003183_-	hypothetical protein	NA	NA	NA	NA
WP_022744210.1\|1003399_1003588_-	hypothetical protein	NA	NA	NA	NA
WP_041716073.1\|1003614_1004106_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_041716470.1\|1004223_1004430_+	hypothetical protein	NA	NA	NA	NA
WP_041716075.1\|1004422_1004764_+	hypothetical protein	A0A2K5B2A7	Erysipelothrix_phage	6.1e-24	59.5
WP_022744213.1\|1004756_1005890_+	DUF2800 domain-containing protein	A0A2K5B2A8	Erysipelothrix_phage	4.6e-169	74.9
WP_022744214.1\|1005894_1006443_+	DUF2815 family protein	A0A2K5B2A9	Erysipelothrix_phage	6.6e-89	89.1
WP_022744215.1\|1008577_1009351_+	phage antirepressor KilAC domain-containing protein	A0A2R2ZGJ4	Clostridioides_phage	2.2e-69	51.8
WP_022744217.1\|1010202_1011069_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_022744218.1\|1011394_1011736_+	hypothetical protein	NA	NA	NA	NA
WP_022744221.1\|1013902_1014727_+	molybdenum cofactor biosynthesis F family protein	NA	NA	NA	NA
WP_022744222.1\|1014797_1015607_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_140395282.1\|1015875_1016085_+	hypothetical protein	NA	NA	NA	NA
WP_022744224.1\|1016407_1016971_+	SLAP domain-containing protein	NA	NA	NA	NA
WP_077393831.1\|1017066_1017681_+\|transposase	IS607 family transposase	Q331V0	Clostridium_botulinum_C_phage	2.7e-78	67.0

DBSCAN-SWA_4

1466870 : 1476876

Prochlorococcus_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_022744581.1\|1466870_1470617_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	6.0e-32	25.2
WP_022744582.1\|1470774_1471254_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	4.8e-27	45.6
WP_022744583.1\|1471253_1471961_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	9.6e-48	43.5
WP_022744584.1\|1472318_1473749_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.0e-56	32.6
WP_022744585.1\|1473758_1474760_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SQF5	Cyanophage	5.9e-67	44.9
WP_022744586.1\|1474747_1475359_+	phosphoribosylglycinamide formyltransferase	R9S626	Prochlorococcus_phage	3.2e-23	37.4
WP_022744587.1\|1475373_1476876_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	E3SNU8	Prochlorococcus_phage	1.4e-35	45.0

DBSCAN-SWA_5

1575080 : 1624426

Emiliania_huxleyi_virus(16.67%)

transposase,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_022744684.1\|1575080_1575800_+\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_022744685.1\|1575929_1576280_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_022744686.1\|1576429_1577296_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_022744687.1\|1577282_1578095_+	ribonuclease HII	G9E3X7	Emiliania_huxleyi_virus	6.3e-19	35.1
WP_022743471.1\|1578298_1579537_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	2.5e-51	51.1
WP_022744688.1\|1579900_1580269_-	YraN family protein	NA	NA	NA	NA
WP_022744689.1\|1580454_1581975_+	YifB family Mg chelatase-like AAA ATPase	NA	NA	NA	NA
WP_022744690.1\|1581990_1583046_+	DNA-protecting protein DprA	NA	NA	NA	NA
WP_022744691.1\|1583091_1585194_+	type I DNA topoisomerase	A0A2K9L1Q2	Tupanvirus	3.2e-107	39.2
WP_022744692.1\|1585387_1586164_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_022744693.1\|1586576_1587278_+	30S ribosomal protein S2	NA	NA	NA	NA
WP_022744694.1\|1587370_1588288_+	elongation factor Ts	NA	NA	NA	NA
WP_022744695.1\|1588409_1589123_+	UMP kinase	NA	NA	NA	NA
WP_022744696.1\|1589133_1589691_+	ribosome recycling factor	NA	NA	NA	NA
WP_022744697.1\|1589960_1590719_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	2.7e-32	49.3
WP_022744698.1\|1590734_1591529_+	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_041716495.1\|1591909_1592878_+	AI-2E family transporter	NA	NA	NA	NA
WP_022744700.1\|1592959_1594120_+	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_158380592.1\|1597778_1598117_-\|transposase	transposase	NA	NA	NA	NA
WP_144079385.1\|1598222_1598984_-\|transposase	transposase	NA	NA	NA	NA
WP_022744706.1\|1600325_1600505_+	hypothetical protein	NA	NA	NA	NA
WP_022744707.1\|1601104_1601287_+	hypothetical protein	NA	NA	NA	NA
WP_140395265.1\|1601250_1601613_+\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_052334787.1\|1601897_1602092_+	hypothetical protein	NA	NA	NA	NA
WP_169729034.1\|1602301_1602562_+	hypothetical protein	NA	NA	NA	NA
WP_052334788.1\|1602653_1603004_+	hypothetical protein	NA	NA	NA	NA
WP_022744709.1\|1603474_1604113_+	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_022744710.1\|1604540_1604954_+	hypothetical protein	NA	NA	NA	NA
WP_022744713.1\|1606147_1606330_+	hypothetical protein	NA	NA	NA	NA
WP_022744715.1\|1607817_1608831_+\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_022744716.1\|1609072_1610122_+	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	NA	NA	NA	NA
WP_022744717.1\|1610392_1610854_+	ribosome maturation factor RimP	NA	NA	NA	NA
WP_022744718.1\|1610871_1612026_+	transcription termination/antitermination protein NusA	NA	NA	NA	NA
WP_022744719.1\|1612039_1612306_+	YlxR family protein	NA	NA	NA	NA
WP_022744720.1\|1612298_1612613_+	ribosomal L7Ae/L30e/S12e/Gadd45 family protein	NA	NA	NA	NA
WP_022744721.1\|1612635_1614720_+	translation initiation factor IF-2	E3T4N3	Cafeteria_roenbergensis_virus	7.5e-24	32.4
WP_022744722.1\|1614734_1615085_+	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_022744723.1\|1615085_1616066_+	bifunctional oligoribonuclease/PAP phosphatase NrnA	NA	NA	NA	NA
WP_041716497.1\|1616116_1616992_+\|tRNA	tRNA pseudouridine(55) synthase TruB	NA	NA	NA	NA
WP_022744725.1\|1617007_1617943_+	bifunctional riboflavin kinase/FAD synthetase	NA	NA	NA	NA
WP_041716156.1\|1618061_1618325_+	30S ribosomal protein S15	NA	NA	NA	NA
WP_022744727.1\|1618433_1620539_+	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
WP_022744728.1\|1620586_1621891_+	insulinase family protein	G3MBJ8	Bacillus_virus	9.7e-46	29.5
WP_022744729.1\|1621957_1622239_+	YlmC/YmxH family sporulation protein	NA	NA	NA	NA
WP_022744730.1\|1622254_1623454_+	aspartate kinase	NA	NA	NA	NA
WP_022744731.1\|1623718_1624426_+\|protease	ATP-dependent Clp protease proteolytic subunit	NA	NA	NA	NA

DBSCAN-SWA_6

2580628 : 2618092

Clostridium_phage(46.67%)

capsid,transposase,plate,coat,integrase

attL 2590245:2590264|attR 2623558:2623577

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_140395234.1\|2580628_2580805_+\|transposase	transposase	NA	NA	NA	NA
WP_022746398.1\|2581125_2581500_-	aspartate 1-decarboxylase	NA	NA	NA	NA
WP_041716243.1\|2581770_2582613_-	pantoate--beta-alanine ligase	NA	NA	NA	NA
WP_022746400.1\|2582696_2583524_-	3-methyl-2-oxobutanoate hydroxymethyltransferase	M4QNT1	Ostreococcus_lucimarinus_virus	5.2e-53	40.1
WP_022746401.1\|2583523_2584594_-	Rossmann-like and DUF2520 domain-containing protein	NA	NA	NA	NA
WP_022746402.1\|2585010_2586372_-	aldehyde dehydrogenase EutE	NA	NA	NA	NA
WP_022746403.1\|2586935_2588609_-	ribonuclease J	NA	NA	NA	NA
WP_022746404.1\|2589263_2589734_-\|coat	spore coat protein	NA	NA	NA	NA
WP_022746405.1\|2589863_2590682_-	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
2590245:2590264	attL	NA	NA	NA	NA
WP_022746407.1\|2591664_2591865_-	hypothetical protein	NA	NA	NA	NA
WP_041716245.1\|2592052_2592274_+	helix-turn-helix transcriptional regulator	A8ASM2	Listeria_phage	1.1e-10	51.6
WP_022746408.1\|2592840_2593095_+	helix-turn-helix domain-containing protein	A0A2H4J358	uncultured_Caudovirales_phage	5.5e-06	44.4
WP_052334804.1\|2593130_2593760_-	DUF4352 domain-containing protein	NA	NA	NA	NA
WP_022746410.1\|2595448_2596054_-	Ltp family lipoprotein	A0A097BY93	Leuconostoc_phage	7.0e-15	72.2
WP_169729028.1\|2596381_2596555_-	hypothetical protein	NA	NA	NA	NA
WP_022746412.1\|2596701_2597106_-	YmaF family protein	NA	NA	NA	NA
WP_022746413.1\|2597269_2597479_-	hypothetical protein	NA	NA	NA	NA
WP_022746414.1\|2597578_2598382_-	glycoside hydrolase family protein	A0A0M5M782	Salmonella_phage	2.4e-10	33.8
WP_022746415.1\|2598439_2598847_-	hypothetical protein	M9Q2G0	Clostridium_phage	6.6e-25	47.4
WP_022746416.1\|2598867_2599104_-	hemolysin XhlA family protein	A0A0A7S0T7	Clostridium_phage	7.4e-05	35.5
WP_022746417.1\|2599219_2600485_-	Ig-like domain-containing protein	A0A1L2BYA9	Clostridium_phage	9.4e-54	56.8
WP_022746418.1\|2600711_2600969_-	hypothetical protein	NA	NA	NA	NA
WP_022746419.1\|2600972_2601410_-	hypothetical protein	NA	NA	NA	NA
WP_022746420.1\|2601428_2602352_-	hypothetical protein	NA	NA	NA	NA
WP_022746421.1\|2602367_2602979_-	YmfQ family protein	A0A0A7RTU9	Clostridium_phage	3.5e-54	54.7
WP_022746422.1\|2602982_2605097_-	hypothetical protein	A0A0A7S1G0	Clostridium_phage	6.6e-68	46.8
WP_077393844.1\|2605098_2605698_-\|plate	baseplate J/gp47 family protein	A0A0A7RUN3	Clostridium_phage	5.8e-46	49.0
WP_022746424.1\|2605897_2606344_-\|plate	baseplate J/gp47 family protein	NA	NA	NA	NA
WP_052334805.1\|2606348_2606798_-	DUF2634 domain-containing protein	NA	NA	NA	NA
WP_041716575.1\|2606790_2607123_-	DUF2577 family protein	NA	NA	NA	NA
WP_022746427.1\|2607158_2609198_-	C40 family peptidase	A0A0A0RR05	Acinetobacter_phage	9.9e-13	37.6
WP_022746428.1\|2609209_2609917_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_022746429.1\|2609928_2611638_-	hypothetical protein	NA	NA	NA	NA
WP_022746430.1\|2611642_2611798_-	hypothetical protein	NA	NA	NA	NA
WP_022746431.1\|2611794_2612223_-	phage XkdN-like protein	NA	NA	NA	NA
WP_022746432.1\|2612324_2612702_-	hypothetical protein	NA	NA	NA	NA
WP_022746433.1\|2612721_2613795_-	hypothetical protein	A0A0A8WJR2	Clostridium_phage	3.1e-29	31.1
WP_022746434.1\|2613796_2614228_-	hypothetical protein	NA	NA	NA	NA
WP_022746435.1\|2614249_2614645_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_022746436.1\|2614637_2614964_-	hypothetical protein	NA	NA	NA	NA
WP_022746437.1\|2614965_2615238_-	hypothetical protein	NA	NA	NA	NA
WP_022746438.1\|2615277_2616309_-\|capsid	major capsid protein	C9E2J5	Enterococcus_phage	7.6e-62	38.9
WP_077393788.1\|2616640_2617000_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_022746441.1\|2617018_2618092_+\|integrase	site-specific integrase	J7KK80	Streptococcus_phage	4.0e-21	34.2
2623558:2623577	attR	NA	NA	NA	NA

DBSCAN-SWA_7

2900435 : 2909442

Clostridium_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_022746692.1\|2900435_2902307_+	PAS domain S-box protein	W8CYF6	Bacillus_phage	2.1e-25	30.5
WP_022746693.1\|2902406_2903441_-	autolytic lysozyme	Q0SPG7	Clostridium_phage	1.6e-27	35.5
WP_022746694.1\|2903523_2903763_-	small integral membrane protein	A0A286QP03	Streptococcus_phage	2.1e-07	46.8
WP_022746695.1\|2903930_2904137_-	hypothetical protein	NA	NA	NA	NA
WP_155738345.1\|2904540_2904696_-	hypothetical protein	NA	NA	NA	NA
WP_140395268.1\|2904796_2905792_-	C40 family peptidase	A0A0A8WF62	Clostridium_phage	2.8e-21	47.0
WP_022746698.1\|2906288_2907380_-	ribose-phosphate pyrophosphokinase	A0A0K1YAT7	Cronobacter_phage	1.3e-06	24.3
WP_022746699.1\|2907684_2909442_-	helicase	A0A248SJQ0	Salicola_phage	6.1e-59	31.6

DBSCAN-SWA_8

3315167 : 3350583

Clostridium_phage(50.0%)

capsid,portal,plate,tail,integrase

attL 3317014:3317032|attR 3359887:3359905

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_022747087.1\|3315167_3315779_-	YmfQ family protein	A0A0A7RTT8	Clostridium_phage	8.8e-50	46.2
WP_022747088.1\|3315775_3316864_-\|plate	baseplate J/gp47 family protein	A0A0A7RUN3	Clostridium_phage	7.8e-81	48.0
WP_022747089.1\|3316856_3317297_-	DUF2634 domain-containing protein	A0A0A7RUS1	Clostridium_phage	1.9e-25	45.5
3317014:3317032	attL	NA	NA	NA	NA
WP_022747090.1\|3317297_3317615_-	DUF2577 domain-containing protein	NA	NA	NA	NA
WP_077393850.1\|3317629_3318373_-	C40 family peptidase	A0A1J0GW44	Streptomyces_phage	3.5e-16	33.3
WP_022747092.1\|3319350_3320052_-	LysM peptidoglycan-binding domain-containing protein	A0A0A7RTT3	Clostridium_phage	6.8e-30	45.3
WP_022747093.1\|3320102_3322073_-	hypothetical protein	A0A218KCH0	Bacillus_phage	1.6e-36	36.8
WP_022747094.1\|3322099_3322246_-	hypothetical protein	NA	NA	NA	NA
WP_022747095.1\|3322263_3322677_-	hypothetical protein	NA	NA	NA	NA
WP_022747096.1\|3322702_3323167_-	hypothetical protein	NA	NA	NA	NA
WP_155762481.1\|3323234_3324278_-\|tail	phage tail sheath subtilisin-like domain-containing protein	A0A0A8WJL8	Clostridium_phage	7.8e-46	33.8
WP_022747098.1\|3324301_3324733_-	hypothetical protein	NA	NA	NA	NA
WP_022747099.1\|3324739_3325111_-	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_022747100.1\|3325103_3325433_-	hypothetical protein	NA	NA	NA	NA
WP_022747101.1\|3325435_3325708_-	hypothetical protein	NA	NA	NA	NA
WP_022747102.1\|3325756_3326788_-\|capsid	major capsid protein	C9E2J5	Enterococcus_phage	1.4e-60	38.7
WP_022747104.1\|3327193_3327832_-	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_022747105.1\|3327987_3328881_-\|capsid	minor capsid protein	A0A1V0DZW9	Clostridioides_phage	9.0e-35	38.2
WP_022747107.1\|3329006_3330344_-\|portal	phage portal protein	A0A1V0DZW8	Clostridioides_phage	8.0e-104	50.7
WP_022747108.1\|3330356_3332183_-	hypothetical protein	A0A1V0DZW7	Clostridioides_phage	7.6e-105	37.2
WP_022747109.1\|3332271_3332871_-	recombinase family protein	M9Q1K0	Clostridium_phage	4.2e-20	34.0
WP_022747110.1\|3333130_3333577_-	hypothetical protein	NA	NA	NA	NA
WP_022747111.1\|3333893_3334337_-	hypothetical protein	A0A090EUN5	Clostridium_phage	4.1e-12	38.0
WP_155762482.1\|3334323_3334506_-	hypothetical protein	NA	NA	NA	NA
WP_022747113.1\|3335052_3335274_-	hypothetical protein	NA	NA	NA	NA
WP_022747114.1\|3335314_3336298_-	hypothetical protein	NA	NA	NA	NA
WP_022747115.1\|3336768_3337464_-	site-specific DNA-methyltransferase	A0A1S5S9L2	Streptococcus_phage	8.4e-89	65.9
WP_022747116.1\|3337598_3340208_-	DNA primase-like protein	NA	NA	NA	NA
WP_022747117.1\|3340223_3340514_-	hypothetical protein	NA	NA	NA	NA
WP_022747118.1\|3340523_3340748_-	hypothetical protein	NA	NA	NA	NA
WP_022747120.1\|3340903_3341395_-	hypothetical protein	NA	NA	NA	NA
WP_022747121.1\|3341394_3341667_-	hypothetical protein	NA	NA	NA	NA
WP_022747122.1\|3341656_3342094_-	hypothetical protein	NA	NA	NA	NA
WP_022747123.1\|3342093_3342774_-	ERCC4 domain-containing protein	F8UBQ2	Clostridium_phage	8.7e-38	43.3
WP_022747124.1\|3342751_3343309_-	HNH endonuclease	A0A0Y0AEJ3	Bacillus_phage	7.3e-27	44.5
WP_022747125.1\|3343383_3344406_-	phosphoadenosine phosphosulfate reductase family protein	F8UBB2	Clostridium_phage	4.1e-68	42.8
WP_022747126.1\|3344447_3344810_-	helix-turn-helix transcriptional regulator	A0A0A8WJ60	Clostridium_phage	6.7e-05	36.2
WP_022747127.1\|3344829_3345420_-	hypothetical protein	NA	NA	NA	NA
WP_022747128.1\|3345422_3346043_-	hypothetical protein	A0A2I7R7K9	Vibrio_phage	3.5e-38	44.2
WP_022747129.1\|3346042_3346243_-	hypothetical protein	NA	NA	NA	NA
WP_022747130.1\|3346251_3346443_-	hypothetical protein	NA	NA	NA	NA
WP_022747131.1\|3346463_3346682_-	hypothetical protein	NA	NA	NA	NA
WP_022747132.1\|3346683_3346836_-	hypothetical protein	NA	NA	NA	NA
WP_022747134.1\|3346966_3347125_-	hypothetical protein	NA	NA	NA	NA
WP_022747135.1\|3347127_3347403_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A2I7SC16	Paenibacillus_phage	6.2e-19	51.7
WP_022747136.1\|3347581_3347785_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_022747137.1\|3348049_3348406_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_022747140.1\|3348943_3349183_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_022747141.1\|3349320_3349611_+	helix-turn-helix transcriptional regulator	A0A0A7RUJ5	Clostridium_phage	7.0e-21	48.9
WP_022747142.1\|3349635_3350583_-\|integrase	tyrosine-type recombinase/integrase	A0A1B1IQT7	uncultured_Mediterranean_phage	2.0e-08	26.4
3359887:3359905	attR	NA	NA	NA	NA

DBSCAN-SWA_9

3851919 : 3911027

uncultured_Caudovirales_phage(51.72%)

capsid,portal,plate,terminase,tail,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_022745633.1\|3851919_3852858_+\|transposase	transposase	NA	NA	NA	NA
WP_022747708.1\|3853142_3854327_-	leucine-rich repeat protein	NA	NA	NA	NA
WP_022747711.1\|3854378_3855071_-	class I SAM-dependent methyltransferase	A0A1V0SKE1	Klosneuvirus	9.8e-05	31.4
WP_041716314.1\|3855373_3855880_-	hypothetical protein	NA	NA	NA	NA
WP_022747720.1\|3857253_3859116_-	transglutaminase domain-containing protein	NA	NA	NA	NA
WP_022747725.1\|3859738_3861448_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	5.6e-09	35.0
WP_022747730.1\|3862019_3862742_+	hypothetical protein	NA	NA	NA	NA
WP_022747735.1\|3863147_3863372_+	DUF1659 domain-containing protein	NA	NA	NA	NA
WP_022747740.1\|3863414_3863633_+	DUF2922 domain-containing protein	NA	NA	NA	NA
WP_022747749.1\|3865500_3865674_-	hypothetical protein	NA	NA	NA	NA
WP_144079372.1\|3865908_3866823_-\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	4.0e-78	63.4
WP_022744350.1\|3866795_3867476_-	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	1.3e-54	50.4
WP_022747754.1\|3867738_3868044_-	hypothetical protein	NA	NA	NA	NA
WP_077393851.1\|3868060_3868408_-	EndoU domain-containing protein	NA	NA	NA	NA
WP_022747762.1\|3869523_3869946_-	hypothetical protein	NA	NA	NA	NA
WP_022747765.1\|3873163_3873742_-	suppressor of fused domain protein	NA	NA	NA	NA
WP_022747770.1\|3874342_3874909_-	CbrC family protein	NA	NA	NA	NA
WP_022747774.1\|3874926_3875754_-	hypothetical protein	NA	NA	NA	NA
WP_041716743.1\|3876467_3877346_-\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_022747783.1\|3877474_3877729_-	hypothetical protein	NA	NA	NA	NA
WP_022747788.1\|3878051_3878360_-	hypothetical protein	NA	NA	NA	NA
WP_022747792.1\|3878378_3878843_-	hypothetical protein	NA	NA	NA	NA
WP_022747800.1\|3879468_3879939_+	DUF4879 domain-containing protein	NA	NA	NA	NA
WP_022747805.1\|3879953_3880292_+	hypothetical protein	NA	NA	NA	NA
WP_022747809.1\|3880802_3882512_-	methyl-accepting chemotaxis protein	NA	NA	NA	NA
WP_022747814.1\|3882835_3883459_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_022747818.1\|3883929_3885309_-	CZB domain-containing protein	A0A2H4J162	uncultured_Caudovirales_phage	2.3e-13	57.3
WP_022747822.1\|3885705_3886089_-	hypothetical protein	I2E8W8	Clostridium_phage	1.6e-17	44.0
WP_022747826.1\|3886136_3886370_-	hemolysin XhlA family protein	A0A0A7S0T7	Clostridium_phage	2.7e-15	52.0
WP_022747842.1\|3886731_3887166_-	hypothetical protein	NA	NA	NA	NA
WP_022747847.1\|3887181_3888216_-	hypothetical protein	S6B1J7	Thermus_phage	1.7e-05	42.7
WP_022747851.1\|3888230_3888848_-	YmfQ family protein	A0A0A7RTU9	Clostridium_phage	5.2e-58	55.9
WP_022747856.1\|3888850_3891364_-	hypothetical protein	A0A0A7S1G0	Clostridium_phage	1.3e-35	63.1
WP_064530754.1\|3891364_3892399_-\|plate	baseplate J/gp47 family protein	A0A0A7RUN3	Clostridium_phage	1.1e-63	43.8
WP_022747865.1\|3892466_3892904_-	DUF2634 domain-containing protein	A0A2H4J4Q8	uncultured_Caudovirales_phage	5.8e-27	44.1
WP_052334841.1\|3892896_3893217_-	hypothetical protein	A0A2H4J746	uncultured_Caudovirales_phage	1.1e-24	53.8
WP_022747875.1\|3893224_3894253_-	hypothetical protein	A0A2H4J063	uncultured_Caudovirales_phage	1.0e-74	47.8
WP_022747880.1\|3894257_3894944_-	SH3 domain-containing protein	A0A2H4J045	uncultured_Caudovirales_phage	3.9e-54	46.9
WP_022747884.1\|3895019_3898733_-\|tail	phage tail tape measure protein	A0A2H4J055	uncultured_Caudovirales_phage	2.9e-79	30.7
WP_022747890.1\|3898919_3899360_-	phage XkdN-like protein	A0A2H4J883	uncultured_Caudovirales_phage	1.5e-30	50.3
WP_022747893.1\|3899649_3900066_-\|tail	phage tail tube protein	A0A2H4J032	uncultured_Caudovirales_phage	6.4e-44	61.4
WP_022747896.1\|3900085_3901510_-\|tail	phage tail sheath family protein	A0A2H4J1N7	uncultured_Caudovirales_phage	9.0e-170	64.0
WP_022747899.1\|3901509_3902031_-	hypothetical protein	A0A2H4J7J8	uncultured_Caudovirales_phage	6.9e-11	68.6
WP_022747902.1\|3902032_3902863_-	hypothetical protein	A0A2H4J4Q0	uncultured_Caudovirales_phage	9.7e-92	59.9
WP_022747905.1\|3902877_3903264_-	hypothetical protein	A0A2H4J057	uncultured_Caudovirales_phage	6.4e-30	53.5
WP_022747909.1\|3903260_3903587_-	hypothetical protein	A0A2H4J040	uncultured_Caudovirales_phage	2.1e-26	58.6
WP_022747914.1\|3903673_3904723_-\|capsid	major capsid protein	A0A0A7RU11	Clostridium_phage	5.0e-93	52.6
WP_022747919.1\|3904824_3905229_-	hypothetical protein	A0A2H4J872	uncultured_Caudovirales_phage	5.7e-05	33.3
WP_022747923.1\|3905244_3905856_-	phage scaffolding protein	S5M9M5	Brevibacillus_phage	1.2e-09	31.7
WP_022747927.1\|3906074_3907718_-\|portal	phage portal protein	D9ZNC8	Clostridium_phage	1.3e-135	52.2
WP_022747935.1\|3908765_3909455_-	GIY-YIG nuclease family protein	A0A1D6Z2A9	Staphylococcus_phage	1.8e-14	45.7
WP_022747942.1\|3910079_3911027_-\|terminase	terminase small subunit	E5DV49	Deep-sea_thermophilic_phage	5.2e-41	36.0

DBSCAN-SWA_10

4713941 : 4722431

Enterobacteria_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_022750200.1\|4713941_4714811_-	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	3.6e-81	53.9
WP_022750204.1\|4715324_4716134_+	phage replisome organizer N-terminal domain-containing protein	V5UQV4	Oenococcus_phage	2.4e-18	41.2
WP_022750206.1\|4716618_4718346_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	1.4e-140	44.0
WP_022750212.1\|4718802_4719873_-	dTDP-glucose 4,6-dehydratase	K7QJG5	Escherichia_phage	4.6e-78	47.3
WP_022750216.1\|4719958_4720840_-	dTDP-4-dehydrorhamnose reductase	H9NCE8	Sphingomonas_phage	5.6e-13	27.5
WP_022750218.1\|4720933_4721515_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	5.3e-52	54.5
WP_022750222.1\|4721525_4722431_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	1.9e-101	61.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022571

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection