CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
NC_022587	Lactococcus lactis subsp. lactis KLDS 4.0325 plasmid 1, complete sequence	0 crisprs	NA	0
NZ_CP029292	Lactococcus lactis subsp. lactis KLDS 4.0325 plasmid unnamed5	0 crisprs	NA	0
NZ_CP029293	Lactococcus lactis subsp. lactis KLDS 4.0325 plasmid unnamed6	0 crisprs	NA	1
NZ_CP007043	Lactococcus lactis subsp. lactis KLDS 4.0325 plasmid 3, complete sequence	0 crisprs	NA	0
NZ_CP007042	Lactococcus lactis subsp. lactis KLDS 4.0325 plasmid 2, complete sequence	0 crisprs	NA	0
NZ_CP029291	Lactococcus lactis subsp. lactis KLDS 4.0325 plasmid unnamed4, complete sequence	0 crisprs	NA	0
NC_022593	Lactococcus lactis subsp. lactis KLDS 4.0325, complete sequence	2 crisprs	cas3,DEDDh,RT,csa3,DinG	15

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2409 : 89513

Streptococcus_phage(20.83%)

transposase,protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080653232.1\|2409_3018_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_080653231.1\|3178_3769_-	DUF805 domain-containing protein	NA	NA	NA	NA
WP_014011544.1\|4673_5816_+	cation:proton antiporter	NA	NA	NA	NA
WP_003129676.1\|5832_7170_+	potassium transporter TrkH	NA	NA	NA	NA
WP_003129675.1\|7189_7858_+	TrkA family potassium uptake protein	NA	NA	NA	NA
WP_032941466.1\|7946_8447_-	hypothetical protein	NA	NA	NA	NA
WP_003129673.1\|8833_9058_-	hypothetical protein	NA	NA	NA	NA
WP_109009842.1\|9059_9869_-	ParA family protein	A0A1V0DZZ0	Clostridioides_phage	1.8e-18	26.8
WP_003129670.1\|10014_11169_-	RepB family plasmid replication initiator protein	A0A1V0E006	Clostridioides_phage	1.1e-05	27.3
WP_109009844.1\|11487_12327_-\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_011669112.1\|12604_13621_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.4e-14	30.9
WP_010906164.1\|13617_14577_+	ABC transporter ATP-binding protein	F2Y302	Organic_Lake_phycodnavirus	7.7e-08	24.7
WP_010906163.1\|14557_15517_+	peptide ABC transporter permease	NA	NA	NA	NA
WP_003140250.1\|15526_16411_+	peptide ABC transporter permease	NA	NA	NA	NA
WP_003132842.1\|20575_20872_+	hypothetical protein	A0A1S5SEW3	Streptococcus_phage	4.2e-05	39.3
WP_003132844.1\|20906_21128_+	hypothetical protein	NA	NA	NA	NA
WP_003132846.1\|21477_22032_-	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	3.6e-42	50.6
WP_011834667.1\|22266_23463_-	amidohydrolase	NA	NA	NA	NA
WP_109009846.1\|23735_25262_-	chitinase	Q9WAX4	Chlorella_virus	1.4e-19	32.1
WP_109009848.1\|25318_27580_-	glycosyltransferase	NA	NA	NA	NA
WP_109009850.1\|28265_29165_-	peptidylprolyl isomerase	NA	NA	NA	NA
WP_109009852.1\|29536_35425_+	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_109009854.1\|36510_37704_-	glycosyltransferase	M1HN86	Paramecium_bursaria_Chlorella_virus	4.0e-46	31.6
WP_002334574.1\|37740_38928_-	nucleotide sugar dehydrogenase	M1HV26	Paramecium_bursaria_Chlorella_virus	6.5e-97	48.8
WP_109009856.1\|39110_39326_-	hypothetical protein	NA	NA	NA	NA
WP_109009919.1\|39783_40095_-	hypothetical protein	NA	NA	NA	NA
WP_109009858.1\|40568_41250_+\|transposase	IS6 family transposase	A0A1X9I6C6	Streptococcus_phage	1.0e-107	83.2
WP_109009921.1\|42230_43481_-	MFS transporter	NA	NA	NA	NA
WP_025017229.1\|43587_44334_-	heme-dependent peroxidase	NA	NA	NA	NA
WP_109009860.1\|44566_45940_-	MFS transporter	NA	NA	NA	NA
WP_109009862.1\|45979_47509_-	copper oxidase	NA	NA	NA	NA
WP_109009864.1\|47603_48284_-\|transposase	IS6 family transposase	A0A1X9I6C6	Streptococcus_phage	3.6e-108	83.2
WP_003137511.1\|50947_51208_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_021214655.1\|51300_51882_+	recombinase family protein	A0A1J1J8Z4	Escherichia_phage	8.5e-34	45.1
WP_109009866.1\|52007_52109_-	type I toxin-antitoxin system Fst family toxin	NA	NA	NA	NA
WP_021214652.1\|52379_53147_-	DeoR/GlpR transcriptional regulator	NA	NA	NA	NA
WP_003131727.1\|53623_54049_+	galactose-6-phosphate isomerase subunit LacA	NA	NA	NA	NA
WP_021214651.1\|54065_54581_+	galactose-6-phosphate isomerase subunit LacB	A0A222YX14	Synechococcus_phage	4.3e-05	36.0
WP_002290553.1\|54591_55524_+	tagatose-6-phosphate kinase	NA	NA	NA	NA
WP_003131732.1\|55526_56507_+	tagatose-bisphosphate aldolase	NA	NA	NA	NA
WP_014011534.1\|56534_56852_+	PTS lactose/cellobiose transporter subunit IIA	NA	NA	NA	NA
WP_021214650.1\|56855_58562_+	PTS lactose transporter subunit IIBC	NA	NA	NA	NA
WP_109009868.1\|58666_60073_+	6-phospho-beta-galactosidase	A0A0B5JD41	Pandoravirus	2.3e-45	29.2
WP_021214647.1\|60364_61264_+	aldose 1-epimerase family protein	NA	NA	NA	NA
WP_025017224.1\|61514_61889_+	large-conductance mechanosensitive channel protein MscL	NA	NA	NA	NA
WP_015081734.1\|64644_65475_+	AAC(3) family N-acetyltransferase	O64018	Bacillus_phage	6.2e-46	39.8
WP_081213844.1\|67973_68255_+	hypothetical protein	NA	NA	NA	NA
WP_050490645.1\|68260_68638_+	hypothetical protein	NA	NA	NA	NA
WP_109009869.1\|68753_69026_-	hypothetical protein	NA	NA	NA	NA
WP_109009871.1\|69039_70197_-	RepB family plasmid replication initiator protein	A0A1V0E006	Clostridioides_phage	4.3e-05	26.1
WP_109009873.1\|71280_71640_-	hypothetical protein	NA	NA	NA	NA
WP_023349191.1\|71706_72597_+\|transposase	IS982 family transposase	NA	NA	NA	NA
WP_032398646.1\|72866_73505_+	hypothetical protein	NA	NA	NA	NA
WP_109009875.1\|73645_75112_+	Y-family DNA polymerase	M1Q231	Streptococcus_phage	8.4e-131	50.9
WP_109009877.1\|75108_75501_+	hypothetical protein	A0A182BQ76	Lactococcus_phage	1.3e-06	60.0
WP_109009879.1\|75515_76541_+	recombinase RecA	A0A2D1GPX2	Mycobacterium_phage	2.4e-71	42.7
WP_109009881.1\|77929_78811_+	hypothetical protein	NA	NA	NA	NA
WP_109009883.1\|79010_79607_-	recombinase family protein	A0A1J1J8Z4	Escherichia_phage	8.7e-34	44.0
WP_109009885.1\|79763_79997_+	hypothetical protein	A0A1X9I6C6	Streptococcus_phage	7.8e-07	90.0
WP_003331414.1\|81655_82414_-	ATPase AAA	A0A059NT77	Lactococcus_phage	5.3e-137	100.0
WP_003331415.1\|82425_83649_-\|transposase	IS21-like element IS712 family transposase	A0A059NT83	Lactococcus_phage	4.9e-233	100.0
WP_109009887.1\|86063_89513_+	type II restriction endonuclease	A0A2R2ZGH5	Clostridioides_phage	3.5e-26	24.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_022593

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CRISPR-Cas detection and classification

Crispr_ID: NC_022593_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022593_1

1494859-1494952

Orphan

Consensus_repeat	Method
ATAAAATGCTCGCTTTGGTCGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022593_1

>merge|NC_022593|1|1494859-1494952|CRISPRCasFinder
ATAAAATGCTCGCTTTGGTCGCTAACGAACGAGAGAATTATCAGCTCCGCTGACAATTCTTTTAGCTATGGATAAAATGCTCGCTTTGGTCGCA

>NC_022593|1|1|1494859-1494952|CRISPRCasFinder
ATAAAATGCTCGCTTTGGTCGCT	AACGAACGAGAGAATTATCAGCTCCGCTGACAATTCTTTTAGCTATGG
ATAAAATGCTCGCTTTGGTCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022593.1\|WP_010905895.1\|1488092_1488719_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227252
NC_022593.1\|WP_023164246.1\|1494072_1494786_-\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234695
NC_022593.1\|WP_012897960.1\|1490990_1491398_+\|protein-export-element	unknown	unknown	gnl\|CDD\|227646
NC_022593.1\|WP_023164243.1\|1491394_1491925_+\|heptaprenyl-diphosphate-synthase-subunit-I	unknown	unknown	gnl\|CDD\|227110
NC_022593.1\|WP_023164248.1\|1496014_1496803_-\|dihydroorotate-dehydrogenase-electron-transfer-subunit	unknown	unknown	gnl\|CDD\|99814
NC_022593.1\|WP_023164255.1\|1504582_1505389_-\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
NC_022593.1\|WP_023164250.1\|1499146_1500358_+\|virion-core-protein	unknown	unknown	gnl\|CDD\|226711
NC_022593.1\|WP_023164245.1\|1492871_1493609_+\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NC_022593.1\|WP_023164241.1\|1486769_1487948_-\|toxic-anion-resistance-protein	unknown	unknown	gnl\|CDD\|377557
NC_022593.1\|WP_003131087.1\|1489978_1490920_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|224131
NC_022593.1\|WP_023164240.1\|1485448_1486597_-\|N-acetylglucosamine-6-phosphate-deacetylase	unknown	unknown	gnl\|CDD\|224733
NC_022593.1\|WP_023164252.1\|1501662_1502448_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224429
NC_022593.1\|WP_023164242.1\|1488910_1489936_+\|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|234629
NC_022593.1\|WP_023164256.1\|1505363_1505708_-\|hypothetical-protein	unknown	unknown	unknown
NC_022593.1\|WP_080681453.1\|1506769_1508254_-\|RTX-toxin	unknown	unknown	unknown
NC_022593.1\|WP_012897978.1\|1502477_1503035_-\|rRNA-large-subunit-pseudouridine-synthase-E	unknown	unknown	gnl\|CDD\|211334
NC_022593.1\|WP_023164249.1\|1497405_1498770_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341046
NC_022593.1\|WP_023164247.1\|1495006_1495942_-\|dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235982
NC_022593.1\|WP_023164244.1\|1491915_1492875_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NC_022593.1\|WP_023164251.1\|1500526_1501666_+\|ATP/GTP-binding-protein	unknown	unknown	gnl\|CDD\|369254

Protein	Function_ID	Function_description	E-value
NC_022593.1\|WP_010905895.1\|1488092_1488719_-\|hypothetical-protein	gnl\|CDD\|227252	COG4915, XpaC, 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only].	2.19745e-89
NC_022593.1\|WP_023164246.1\|1494072_1494786_-\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234695	PRK00230, PRK00230, orotidine-5'-phosphate decarboxylase.	7.34693e-133
NC_022593.1\|WP_012897960.1\|1490990_1491398_+\|protein-export-element	gnl\|CDD\|227646	COG5341, COG5341, Uncharacterized protein conserved in bacteria [Function unknown].	7.84966e-52
NC_022593.1\|WP_023164243.1\|1491394_1491925_+\|heptaprenyl-diphosphate-synthase-subunit-I	gnl\|CDD\|227110	COG4769, COG4769, Predicted membrane protein [Function unknown].	1.86202e-64
NC_022593.1\|WP_023164248.1\|1496014_1496803_-\|dihydroorotate-dehydrogenase-electron-transfer-subunit	gnl\|CDD\|99814	cd06218, DHOD_e_trans, FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as 3 cofactors: FMN, FAD, and an [2Fe-2S] cluster.	4.12713e-109
NC_022593.1\|WP_023164255.1\|1504582_1505389_-\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	8.3145e-27
NC_022593.1\|WP_023164250.1\|1499146_1500358_+\|virion-core-protein	gnl\|CDD\|226711	COG4260, COG4260, Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism].	4.49543e-168
NC_022593.1\|WP_023164245.1\|1492871_1493609_+\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	1.1896e-84
NC_022593.1\|WP_023164241.1\|1486769_1487948_-\|toxic-anion-resistance-protein	gnl\|CDD\|377557	pfam05816, TelA, Toxic anion resistance protein (TelA). This family consists of several prokaryotic TelA like proteins. TelA and KlA are associated with tellurite resistance and plasmid fertility inhibition.	9.67435e-125
NC_022593.1\|WP_003131087.1\|1489978_1490920_+\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	1.35337e-172
NC_022593.1\|WP_023164240.1\|1485448_1486597_-\|N-acetylglucosamine-6-phosphate-deacetylase	gnl\|CDD\|224733	COG1820, NagA, N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism].	1.90012e-178
NC_022593.1\|WP_023164252.1\|1501662_1502448_+\|hypothetical-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	1.05807e-70
NC_022593.1\|WP_023164242.1\|1488910_1489936_+\|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase	gnl\|CDD\|234629	PRK00094, gpsA, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.	3.1574e-179
NC_022593.1\|WP_012897978.1\|1502477_1503035_-\|rRNA-large-subunit-pseudouridine-synthase-E	gnl\|CDD\|211334	cd02566, PseudoU_synth_RluE, Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.	2.69982e-100
NC_022593.1\|WP_023164249.1\|1497405_1498770_-\|MFS-transporter	gnl\|CDD\|341046	cd17503, MFS_LmrB_MDR_like, Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.87271e-66
NC_022593.1\|WP_023164247.1\|1495006_1495942_-\|dihydroorotate-dehydrogenase	gnl\|CDD\|235982	PRK07259, PRK07259, dihydroorotate dehydrogenase.	0
NC_022593.1\|WP_023164244.1\|1491915_1492875_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	3.51865e-84
NC_022593.1\|WP_023164251.1\|1500526_1501666_+\|ATP/GTP-binding-protein	gnl\|CDD\|369254	pfam07191, zinc-ribbons_6, zinc-ribbons. This family consists of several short, hypothetical bacterial proteins of around 70 residues in length. Members of this family have 8 highly conserved cysteine residues, which form two zinc ribbon domains.	0.000852226

>NC_022593.1|WP_023164246.1|1494072_1494786_-|orotidine-5'-phosphate-decarboxylase
MQENRPVIALDFPEFSDVKDFLEKFDPSEQLYIKLGMELFYTAGPQVVYYVKSLGHSVFLDLKLHDIPNTVESSMRVLARLGLDMVNVHAAGGVEMMVAAKRGLEAGTPVGRQRPKLIAVTQLTSTSEKIMQNDQKIMTSLEESVINYAQKTAQAGLDGVVCSAHEVEKIKAATSKEFICLTPGIRPEGASKGDQKRVMTPKEARTIGSDYIVVGRPITQAKDPVASYHAIKAEWNQ
>NC_022593.1|WP_023164245.1|1492871_1493609_+|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MTPDEFLSALTEFDIQLSDKQIKQFERYFELLVEWNEKINLTAITEKNEVYLKHFYDSIAPILYGLITDQPVSILDIGAGAGFPSLPMKIIFPELKVTIIDSLNKRINFLSLLTEELGLENVTLLHGRAEDFGRDANYRGTFDFVTARAVARLSVLTEFTIPFLKKNGILLSLKAAQFEEELNDAKKAIATLGGKFIKEVAYELPNGDERHIALIEKKKETPKKYPRKAGTPAKKSNKIKKYGHF
>NC_022593.1|WP_023164244.1|1491915_1492875_+|polyprenyl-synthetase-family-protein
MDLKNNFWKDYPELEKELVQVQQLMKSHVTIKNSDVKSAIFDIFDAGGKMLRPAYLLLFSGFTDLSENERLALAASVEMMHTATLVHDDVIDHADTRRGVATLSAKYGPEIAVYAGDYLFIAVFRLMSEHSLELSNLTKNIGSIERLLGGELGQLNHHFNLQQTLDDYIENISGKTGELFALSASVAPLISKNNTLTKRAYKIGMNIGISFQIMDDYLDYASTAQTLGKPVLEDIKQGIYSAPVLFALQENNALVSELIKNEKFDEVYDFIKTSDALEKTKALAKSYTLSALNLIDKLPKGKNRELIAEITRKLLERSL
>NC_022593.1|WP_023164243.1|1491394_1491925_+|heptaprenyl-diphosphate-synthase-subunit-I
MNIKEYVYVSLLTAAAVVMGIIESSLPPFFAFAPGAKVGLANLVMIIAVFTLRWRQVWVMQILRLLITALFTGFSVFLYSFAGGILSLLVMYLMKQFGPKLVSMIGISTVGGFFHNFGQLAMASLLAKTTSVMLYLPWLAFFGILAGFAIGIAGNQLITRVKPIQELFIKESKQWT
>NC_022593.1|WP_012897960.1|1490990_1491398_+|protein-export-element
MNFFKNTVNFFKSIKTKPLDFVIIFLLFIASFSTLFFFATGSKGAQAELRISGKVIKTFDLNKNQTWTYRDKDGDYNKIQVKNGEIAVVEANCKDQIDVQRGYISKTGETIVCLPHNLVIEVMSGQKDEQVDYKV
>NC_022593.1|WP_003131087.1|1489978_1490920_+|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MKQNIIPTKARKVRKAVIPAAGLGTRFLPATKAIAKEMLPIVDKPTIQFIVEEALKSGIEDILIVTGKAKRPIEDHFDSNIELEQNLLEKGKTELLKLVEETTDINLHFIRQSHPKGLGHAVLQAKAFVGNEPFVVMLGDDLMNITGNETPLTKDLINDYEKTHASTIAVMKVPHDDVDKYGVIDPNGEVSKGLYNVERFVEKPNVDEAPSDLAIIGRYLLTPEIFDVLETQVPGAGNEIQLTDAIERLNKTQRVFAHEFTGKRYDVGDKLGFVETTIEYGLEHPQIGANLKNYIIEKAKELSKDDSKNITKK
>NC_022593.1|WP_023164242.1|1488910_1489936_+|NAD(P)H-dependent-glycerol-3-phosphate-dehydrogenase
MNPQKIAVLGPGSWGTALSQVLNDNGHEVRIWGNNPEQMAEINEKHTNTRYFKDVVLDKKIKAFDRLDLALEDVDAILFVVPTKVTRLVAKQVAEVLKHKVHILHASKGLEQGTHERISTILEEEIPAQLRGEIVVVSGPSHAEETIVRDITLISAASKNHDEAKYAQAIFSNDYFRLYTNTDVVGVETAGALKNIIAVGAGALHGLGFGDNAKAAIITRGLAEITRLGVAMGAEPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGEKLADIEKNMGMVIEGVSTTKAAFELAQQLDIDMPITETIYKVLYENLDAKTGILDIMRRETRAENEFINNK
>NC_022593.1|WP_010905895.1|1488092_1488719_-|hypothetical-protein
MPVSLFMNHQDMMFGYGHLGIVNVIFGLVLFFLIIKMIIGISFMRKNPDEREEGYKDKGMSKKENIERYHEAGLSDTDIKIFRENLSEAKENIKTWEKLLKKEDDLQVVESVTGGLEASKQTFKYIVQNPQELTKQNEFLYKDLPNMVKLSEKFIEMKKQSVRTEEINRDLDETLLLIKTLSHSISKNYHEILMDDVNVIKHQVDFDK
>NC_022593.1|WP_023164241.1|1486769_1487948_-|toxic-anion-resistance-protein
MDNPILDDLITNDKVIKEAEQLDEQQKSEIVKMHEKASLAAVEVLSTEELEKAKELSKQLDESSAQSVINYGASAQDKISAFSQSVLNKVQAQDLGEVGSSLTDLMFNLQQANPNELVAENKGIFTKMFGKVKRSIFEVTQKYQKIGAGIDKISAKLNNEQQGLLQDNEMLDKLYDENLNYFKALNVYIAGAELKVQELDTEIIPQARKEAHDSTDNALIVQKVNDLESYKNRLEKRAHDLRLARQLTIQQAPQIRLIQNTNQELAEKIQTSINTAIPLWKNQVAIALTLLKQKDALTSQRIVSETTNDLLRKNSEMLKASTIEAATENERGLVDIETLKLTQQNLVDTIQETMRIQAEGRQKRQQGEVELSKMEEEIKEKLLQLSNNKQLN
>NC_022593.1|WP_023164240.1|1485448_1486597_-|N-acetylglucosamine-6-phosphate-deacetylase
MTYYIKADQFFYAYETKKGGFLEITDGKFGEWTEEAPAGADILDYSGQSIAPGLVETHIHGFGGADAQDAEVEGIMGTMSEGLLSAGVTSFLPSPLTDDHEGLKAVCTVVGEHYQEARGAKVRGIFFEGPFFTEEKKGAQNPKYMRDAKMWELEDWQEAAHGMLKKIGLAPERDGSEDFIRKATESGVVIALGHSNATYKQAVDGVQAGASVWVHTFNGMSGMTHQEPGMVGAILNTPNTYAELICDGHHVRPEAAEIVMKMKGADHVVLITDSMRAAGLPDGPYMLGEYEVEVRDGAAWLPTGRPAASILTLKTAVKNVIDWGIATPAEAIMMASLTPAKSVNIDDVCGQIKPGLSADFIVLDNDFDLVATYLDGEKRYEA
>NC_022593.1|WP_023164247.1|1495006_1495942_-|dihydroorotate-dehydrogenase
MTENNRLSVKLPGLDLKNPIIPASGCFGFGEEYAKYYDLNKLGSIMVKATTLHPRFGNPTPRVAETASGMLNAIGLQNPGLEVIMAEKLPWLNENFPDLPIIANVAGSEEDDYVAVCAKIGDAPNVKAIELNISCPNVKHGGQAFGTDPDVAAALVKACKAVSKVPLYVKLSPNVTDIVPIAKAVEAAGADALTMINTLMGVRFDLKTRKPVLANITGGLSGPAIKPVALKLIHQVAQVVDIPIIGMGGVESAQDVLEMYMAGASAVAVGTANFADPFVCPKIIEKLPEVMDQYGIDSLENLIQEVKNSKK
>NC_022593.1|WP_023164248.1|1496014_1496803_-|dihydroorotate-dehydrogenase-electron-transfer-subunit
MPKLQEMMTIVSQREVASNIFEMVLKGELVEEMDLPGQFLHLAVPNASMLLRRPISISSWDKVAKTCTILYRIGDETSGTYEISKLQTGAKIDVMGPLGNGFPVDEVVSTDKILIVGGGIGVPPLYELAKQLEEKNCQMTILLGFASEKVKILEKEFAELKNVSLKIATDDGSYGTKGHVGMLMEEIDFEVDALYTCGAPAMLKAVAKKYEQLERLYISMESRMACGIGACYACVEHDKEDENHALKVCEDGPVFLGKQLSL
>NC_022593.1|WP_023164249.1|1497405_1498770_-|MFS-transporter
MNKNNHFHLLGAVIATGILSFSGVLIETAMNVTFPTLINEFGLSTSKIQWVTTIYLLVIAITIPLSSYFNERFSARKLFLVANLIFLVGVLTNCFSPNFAMLLFGRLLQGVGTGIGLPLMFHLILTKAPLHKRGMMMGIGTLTTSIAPAIGPTYGGIISNSLDWRYIYIFLLPLVVISLVLGLACLPREGAKTPKKLALRPVIALSIMFFAFISALSAEHLMTFALLFIVGLVGAFLFVQFNRKESLIDLGILKNHRFVALIFSLLVYQALLLGLSFVLPSFIQVSAGFSSSVAGLFMFPGALIGAVLAPISGKVLDQIGARKPITTGLILAALGLALLFVFLPTKSLALLLVAHIVLMLGLGISYSNLMTCSLSTLATDQLSDGNALVNTLQQFIGAVATAVVATTLSIFQGHNGFKVGTSHGTSIILALFFILIIVSLIVSFPNLKKIRANH
>NC_022593.1|WP_023164250.1|1499146_1500358_+|virion-core-protein
MGIIKAATGSLGGALADQWLEVIEPNEMSNQTVFTKGIKVRKDAKRGSNRKGTEDVITDGSIVHVYENMMMILVDGGKIIDYTAEPGYYTVKNDTAPSLFNGDLRDSIQESFFRFKFGGTTPQKQEVYYVNLQEIKGIKFGTATPLQYFDNFYNAELFLRTHGTYSIKITDPLAFYANVIPKNADHVEIQEINDQYLAEFLTALNTSINQYSAQGERVSFLTSKSMELSKYMASVLDEDWKQLRGMEIVSVAVASISYTDDSQKLINMRNQGAMLGDPSIREGFVQGAVARGLEAAGSNTGGATNAFMGMNMGGQNLAGFSQTNQAQMQAQAENKADTWTCPECNTKNTGKFCSNCGQAKPSATPVMPELNMACNECGAVVNLANGVPKFCPECGKPFVAKAL
>NC_022593.1|WP_023164251.1|1500526_1501666_+|ATP/GTP-binding-protein
MSESQVLTHKCPNCGGPLLFEPKNQKFHCEYCGSTFTEQEVSDFEAKQEAAKVTDSPISSVSNAETTDEKEKITDSDQKRADENTDEEIGLFLCPSCGAEIVTDATTASTWCYYCHNPVVLTERLSGKFLPEKILPFQIERKAAEEQFLDWVGKKKFVPKAFFDKKQIQNLSGVYFPYWAVDAELSGGISAQATNLRVWIVGDTEYTEHSQYEIQRGGETKFKDLIKNALKKNLSDKMVGAVQPFDMTAAIPFKNQYLSGFLTEKRDIEFPDMKENVEREFRQYADGLMESTIVGYTSVSNLQSNQQIKNIDEDYVLLPIWLVTYKEAGNDRLFYYAMNGQTGKVAGLLPIDKKKLWTVAIGIFILVLLLGIIVGYLLS
>NC_022593.1|WP_023164252.1|1501662_1502448_+|hypothetical-protein
MRKKLVFLSLFFLSFFFLLIAPKTSAATFSSGLEDNLQLLGGNVTLLEQEAQKLANETKAGVYVVTTDSSTPASQMAKTYLADKVGAKNNGVILVINMNLRKVYIWATGNLKYYLPSSRIEKTLDIVQPELTDNNYYQAVSGFFDQVSKYYQAGIPTSRKYSINSETGAVTFHRSFQPLSILIALIISLIAAGGFVWTIYRRYQMKDAHAVWRYDYGRNGNLELHQREDILVNTFITTRIIPRPSSDNNNFSDGSGGGRSF
>NC_022593.1|WP_012897978.1|1502477_1503035_-|rRNA-large-subunit-pseudouridine-synthase-E
MNFCKKIMIILFNKPYDVLTKFTDGEGRKTLKDYIKIPNVYAAGRLDKDSEGLLLLTDDGKLNHLLTDPKSKSYKTYLVQVEGEFSSEAAQKLQKGLLLKDGKTLPAKVKLIDEPDWLWERTPPIRERKAIPTSWVEISIKEGKNRQIRRMTAAVGFPTLRLIRWSIGQYSLGNLKSGEYKIIQK
>NC_022593.1|WP_023164255.1|1504582_1505389_-|WxL-domain-containing-protein
MKKTILSLSGVAVITATLLSTSVLEVSATSVGSTTSGANVAFQPKKTPTNPVSPGDGKTPISPTTPGVPNTSNPVASDDGLTLDYVPAINFGTHYVDASTAHTWSAWAANDGSGKAIPQFMQVTDNRGTATGPTGWSVSLTQTAQFKGTKAGDLVNAVMTFNNDKTNTVVSTSMNKASSTVNTATNALVPGTAVNIFQADAGTGTNLLSFGAGDGSTLVTDPETLDSATNTTGKVDPNITLNVPAGSAKVDTYTTTLNWNLYSAPGNA
>NC_022593.1|WP_023164256.1|1505363_1505708_-|hypothetical-protein
MKIKYILWVICALLLLNTSVILAQEIGGTNTTGKVGFLEKEPIEKPPVTSSSQATGQSQILTNQYLPIVGTNQNDPLMPFVVGLVTIGVGSLMIKKTKRIRIKENFNEKNNTQP
>NC_022593.1|WP_080681453.1|1506769_1508254_-|RTX-toxin
MKGLNAKATAVYENVTVSNGDAIYGAQPIRNDNGKVLFRGTNTFNILQNHNINDTSSAGADNQGEWIQGGAYLEVVTGTTTLNQSWGNDQPFYVYYSSGGSTLQVDAGAAMVWNLNKTYTMYYDDGSLLTVGALNWNINGSFVINGTVNTSSTYAGGWFMALNTLNSWNLNVGQNATLKVTTGGVISLDAFLTGAVKWNFAQGSSVLFNNLNPNQNVVSLAPGLGSSITMTDPKVVTFNTAGGSVFSTTVLTFPITISGSGLRTHSSSTGYTFDSTYDLITPTKGTITPTSSDIWYRMNTGTLTTFNPTLQVTNLSPNSYGSDASSIAAGKYISWYQPLGFQLNATLSSMNRTFNVSLDPTLTQGTPVDGSWSSLINGASTETLVVGDDRAQNPNIHVLVKMTQNNFPNGLQYYWVDPTTKTASQLSLNSALQIASITSDSTLPSWIKMTGAGSWYTMTFPTDSGLNIKANNSLLTQTNTNAGTFQYTVANGPS

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Crispr_ID: NC_022593_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022593_2

1968061-1968155

Orphan

Consensus_repeat	Method
TTTATTACTGACAGACTTGTCAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022593_2

>merge|NC_022593|2|1968061-1968155|CRISPRCasFinder
TTTATTACTGACAGACTTGTCAGCTTTGCTGACAAATCCTTCATCCATTGATAAAAAGCTCAATTCAATCGCTTTTTACTGACAGACTTGTCAGC

>NC_022593|2|2|1968061-1968155|CRISPRCasFinder
TTTATTACTGACAGACTTGTCAGC	TTTGCTGACAAATCCTTCATCCATTGATAAAAAGCTCAATTCAATCG
CTTTTTACTGACAGACTTGTCAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022593.1\|WP_023164477.1\|1969331_1970549_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NC_022593.1\|WP_004255224.1\|1961167_1961737_-\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|224187
NC_022593.1\|WP_023164474.1\|1960190_1961162_-\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|237010
NC_022593.1\|WP_023164476.1\|1964582_1964876_+\|hypothetical-protein	unknown	unknown	unknown
NC_022593.1\|WP_010906135.1\|1963112_1964261_+\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|273881
NC_022593.1\|WP_023164481.1\|1976620_1977529_-\|diacylglycerol-kinase-family-lipid-kinase	unknown	unknown	gnl\|CDD\|224513
NC_022593.1\|WP_004255173.1\|1974221_1974923_-\|adaptor-protein-MecA	unknown	unknown	gnl\|CDD\|227199
NC_022593.1\|WP_010906134.1\|1959868_1960174_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226801
NC_022593.1\|WP_004255171.1\|1975052_1975787_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NC_022593.1\|WP_023164480.1\|1972887_1974219_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NC_022593.1\|WP_010906137.1\|1964872_1965619_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187594
NC_022593.1\|WP_004255158.1\|1975786_1976473_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NC_022593.1\|WP_004255207.1\|1966627_1968040_-\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NC_022593.1\|WP_010906139.1\|1968847_1969330_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223659
NC_022593.1\|WP_023164478.1\|1970548_1971805_-\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NC_022593.1\|WP_023164479.1\|1971942_1972713_-\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NC_022593.1\|WP_010906138.1\|1965641_1966487_+\|2-nitropropane-dioxygenase	unknown	unknown	gnl\|CDD\|132195
NC_022593.1\|WP_023164475.1\|1961881_1963123_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|341288
NC_022593.1\|WP_004255197.1\|1968273_1968732_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918
NC_022593.1\|WP_010906136.1\|1964245_1964608_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022593.1\|WP_023164477.1\|1969331_1970549_-\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NC_022593.1\|WP_004255224.1\|1961167_1961737_-\|biotin-transporter-BioY	gnl\|CDD\|224187	COG1268, BioY, Uncharacterized conserved protein [General function prediction only].	5.72661e-47
NC_022593.1\|WP_023164474.1\|1960190_1961162_-\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|237010	PRK11886, PRK11886, bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA.	2.48657e-70
NC_022593.1\|WP_004255171.1\|1975052_1975787_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.02808e-157
NC_022593.1\|WP_010906135.1\|1963112_1964261_+\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|273881	TIGR01930, 3-ketoacyl-CoA_thiolase, acetyl-CoA acetyltransferases. This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation. [Fatty acid and phospholipid metabolism, Other].	4.30804e-158
NC_022593.1\|WP_023164481.1\|1976620_1977529_-\|diacylglycerol-kinase-family-lipid-kinase	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	8.86495e-71
NC_022593.1\|WP_004255173.1\|1974221_1974923_-\|adaptor-protein-MecA	gnl\|CDD\|227199	COG4862, MecA, Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion].	3.81196e-86
NC_022593.1\|WP_010906134.1\|1959868_1960174_-\|hypothetical-protein	gnl\|CDD\|226801	COG4357, COG4357, Zinc finger domain containing protein (CHY type) [Function unknown].	1.12966e-28
NC_022593.1\|WP_023164480.1\|1972887_1974219_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	9.45595e-85
NC_022593.1\|WP_010906137.1\|1964872_1965619_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	4.80083e-73
NC_022593.1\|WP_004255158.1\|1975786_1976473_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.09368e-76
NC_022593.1\|WP_004255207.1\|1966627_1968040_-\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NC_022593.1\|WP_010906139.1\|1968847_1969330_-\|hypothetical-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	3.28577e-22
NC_022593.1\|WP_023164478.1\|1970548_1971805_-\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	2.36892e-131
NC_022593.1\|WP_023164479.1\|1971942_1972713_-\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	2.84318e-148
NC_022593.1\|WP_010906138.1\|1965641_1966487_+\|2-nitropropane-dioxygenase	gnl\|CDD\|132195	TIGR03151, enACPred_II, putative enoyl-[acyl-carrier-protein] reductase II. This oxidoreductase of the 2-nitropropane dioxygenase family (pfam03060) is commonly found in apparent operons with genes involved in fatty acid biosynthesis. Furthermore, this genomic context generally includes the fabG 3-oxoacyl-[ACP] reductase and lacks the fabI enoyl-[ACP] reductase.	3.58449e-84
NC_022593.1\|WP_023164475.1\|1961881_1963123_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|341288	cd17633, AFD_YhfT-like, fatty acid-CoA ligase VraA. This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain	2.79647e-68
NC_022593.1\|WP_004255197.1\|1968273_1968732_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	9.34852e-67

>NC_022593.1|WP_004255207.1|1966627_1968040_-|Fe-S-cluster-assembly-protein-SufB
MTENSTQEVVKDLEEYKFGFHDNAELEFTTGLGLTEEVIREISETKNEPEWMLEFRLKSFEAFKKLDMPKWGPDLSGIDFNDIVYYQKPSAKAARSWEDVPQEIKDTFEKIGIPEAERSYLAGASAQYESEVVYHNMKDEFEKLGIIFTDTDSGLRDYPEIFKKYFSKLVPPTDNKLAALNSAVWSGGSFVYVPKGVKCEIPIQAYFRINNEKSGQFERTLIIVEEGASIQYVEGCTAPTYSASSLHAAVVEIFVEEGGYMRYSTIQNWSDNVYNLVTKRAAAEKNATVEWIDGNLGSKVSMKYPAVHLNGPGARGTMLSIAFAGANQNQDTGAKMIHNAPNTSSSIISKSIAKNGGAVNYRGQVTFGKNSKKSASHIECDTILMDDLSKSDTVPFNEIHNSQVALEHEAKVSKISEEQLYYLMSRGLTEKEATDMIVMGFIEPFTKELPMEYAVELNRLISYSMEGSIG
>NC_022593.1|WP_010906138.1|1965641_1966487_+|2-nitropropane-dioxygenase
MTWYHELGIKYPLFQGGMAWASNAELVAAVSNNGALGIIGSGGRTANELRRMIRKTKTLTSQPFGVNLMLLDKNIKQLLEVICEEKISVVTTGAGSPKEIIDTIIANNIKLFPVVPNKEIALKMLNLPISGIIVEGNEAGGHVGSQNLASLLKEIAPICPLPLIAAGGIYDHHTASLANILGANGVQVGTAFLLAKECQISPIYQELICKGEENGTSLISDKNGHLTRLLNISSEYPLNKSLKAAVEKGDLINGAFMAGSSSAYLEKIEPVENIIQRIMKK
>NC_022593.1|WP_010906137.1|1964872_1965619_+|SDR-family-NAD(P)-dependent-oxidoreductase
MNKRTILITGATRGIGWAIAQKAAQANHKVILTGRDPLSLKSRAEELKKKFPKTEIQAIPLDVSNRSSVANAAKLIKDIDILINNAGITADSTFKKMSPEIWDEVISVNLTGVFNSTHALLDKINQGGQIITLTSKSALFGNFGQANYAASKAGIIAFTKTLAKELQKSMIRVNSVSPAAVTDMTLPVLKSLKETYGQNIPDEWKMGSSSDVANFIINDLIESEMTGKIFSINGSEIGYWQEPTFHKL
>NC_022593.1|WP_023164476.1|1964582_1964876_+|hypothetical-protein
MKLYKKINKADLIDYLQSVKDTNSLHYGKNPIIPGNFLLFILEEMYQEFYSMPLSYLKANFCSPAYLNERFCFIFNQNAFQITDSNQTLILKGEWKQ
>NC_022593.1|WP_010906136.1|1964245_1964608_+|hypothetical-protein
MVSKMILIAQKSLPRHFKLEGQKNFLSLLPQLWQELEGIPYSLKNGENWLLSEEIIRYPSSNYSFDKLKLYLLSEHITRHSKKYIINLSLEITSNTKLLAQINLSLLSEDSWNEIIQKNQ
>NC_022593.1|WP_010906135.1|1963112_1964261_+|acetyl-CoA-C-acyltransferase
MSFKNPVGIIAANRLPIGKINGFYKKISPETLYQNLIKQQFNKNLLLKKADIDYIILGNVTNQGGNLARRCALKAGFSSQVPAFTIDQQCGSGLTAMISSANYIISGEASVICTGGVESTSQANIVLDSESYQPINRFKMAPEPYEDFDMGTIADMTALKYNIPRSVQDLYALNSHKKATQAIEGKLLENEVFPYQDEGFTISSDQTVRPKSSMEALSKLTPAFTTNGTATAGNSCPINDGASSIILSSTNNPFDFQGYYLGQTTIALSPSDFLLGPIKATEKLLQKFNLKLNDIEAIELNEAFASQAILFQNYFKLDDIKLNAYGGSLAFGHPYGATGGILISRLLNRLNQVQKPCLGIATLCVAGGMGISVLIGNQWYQK
>NC_022593.1|WP_023164475.1|1961881_1963123_+|long-chain-fatty-acid--CoA-ligase
MEKNKFNFSKLAALFTDYPALKIGDISYSYQQINDLIQRKLTDYSHSSKTVITLINDSPLNFIIDFLAIIESGNYPLVVDKSFKKKSFEFGLIPEDTLFLASTSGTTGPPKIYYRNWESWKMGFEVCDDLFHLSNSQALATTSPLTTSLGLHTLMCALYLGKTFLTITNPSQFINITENYALFTVPTYLLNNLNELFALTSPEIIFLGGGTLSPEAINKVRKKLPQTQMIEFYGSSETSFISWQAVNEGKKTSSVGKLFPHVELTLGPKYRLTVKSPYLFSGYLNQPYPQSWTTDDLGTLKNNHLYLFGRRSDIIEHGANKIFPEEIERMAKDLCEDCIAFGVFDERYSQKIALLLLKPIEKEKLIKILAQRLPKYKLPQIYLETPTLNFTKNQKISRKELEKEYFRGVYHEL
>NC_022593.1|WP_004255224.1|1961167_1961737_-|biotin-transporter-BioY
MTKNQKVKTLTYSAFMTAFIIILGFLPGIPIGFIPVPIILQNMGIMMAGGLLGPKYGTISVGAFLTLALIGLPVLTGGNGGAASFLGPSGGYRMAWLFTPFLIGFFLKKLQITASKNWIGELIIVLVFGVIFVDLVGAIWLSIQSNIPLITSLISNLVFIPGDCIKAILTVLIVRRLRKEGGFEMYFRK
>NC_022593.1|WP_023164474.1|1960190_1961162_-|biotin--[acetyl-CoA-carboxylase]-ligase
MRTTKQFVLLKLLQQKGNWVSGDELAEELKLSRESIWKAINTLKRKGNQIESRKNLGYKYVGNDSLDEDTINFYSGMKFEDKIFVFDEVTSTQELAKQYLSSHEVKQPFIFVANNQTEGHGRRGRNFYSPSDTGLYFSLILPNPSHDILKIGLLTTSTAVAVVKVLEQFYKDKNFQLKWVNDIYLGTYKVGGIITEAALDLESSSAGNFIMGIGLNLSTKDFPADLSEKAQGINPEFKIDRNQLLAEMAKEVINNFANYRQPDLIDEYRKRSLLFGKNVTLKLGTKAVNGKVEGISDDGSLILKAKSGELQTFKSGEVVKVDW
>NC_022593.1|WP_010906134.1|1959868_1960174_-|hypothetical-protein
MREKIWGKVIDEEGRCTHYHQENDIVALKCSDCEKYFSCYHCHDELENHLFRATDKEDFPVLCGHCGKKLNFNDYSRGECIKCSSAFNPNCHRHWQVYFNE
>NC_022593.1|WP_004255197.1|1968273_1968732_-|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MALSKLDNLYRAVILDHSSNPRHAGELQTGCMVDLNNPTCGDVIRLTVEFENDVISNIAFSGHGCTISTASASMMTVAVLGKTKEEAKELATIFSAMVTGETDERQEKLGDAQFLAGVSKFPARVKCSTLAWNALKKAIDVGEAQETVIHGE
>NC_022593.1|WP_010906139.1|1968847_1969330_-|hypothetical-protein
MLNWVASLPLWLATTFLFVVVFFRAQCTFWLGKLSYHGILKTKWGKKLEKNSETSAGILAIQKMGWPIIPLSFLTVGFQTAVQFGAGLTNWSWYKYTLAAIPGYLAWGFIYASGGLSLFRSLVQGSIGLLILFIIIILAVVIAANLVLRYIRKNGIKTDD
>NC_022593.1|WP_023164477.1|1969331_1970549_-|cysteine-desulfurase
MLEGIKKDFPVLNQIVNDEPLVYLDNAATTQKPLKVLAAIKDYYENDNANIHRGVHTLAERATEKYEAAREKVRQFINAKSTKEVLFTRGTTTSINWVAQFAGQILKTGDEIVISIMEHHSNIVPWQEVAKKTGAILKFVYLKDGQLDMDDLRKKITNQTKFVSIAHVSNVLGTINPVEEITKIAHEHGAYMAVDGAQSTPHMAIDLQKMDVDFFAFSGHKMMGPTGIGVLYGKEELLNQFEPVEFGGEMIDFVYESHSTWTELPWKFEAGTPNIAGAIALGAAIDYIQELGIDQIHQHEIELIDYLMPKLQEIEGLKIYGPKDNVKRGGLIAFNIEGLHPHDVATALDMEGVAVRAGHHCAQPLLNYLETPATARASFYLYNTKADCDKLVEALKKTKEFFNLD
>NC_022593.1|WP_023164478.1|1970548_1971805_-|Fe-S-cluster-assembly-protein-SufD
MNQEILNFSQMHAEPAWLSDLRQKSALEFENLELPNIERVKINRWGLDHLSISENEEIGSVPTFTEIPNHPLLVQVGSQTVMEQMTPNLAEQGVIFTDFNSALTEIPELLEENFGSVVPFNESRLTAANTATFNSGLVLYVPDGVEVLEPIESILMQEGSSEVPFNKRILIIVGKNAKVDYLERLETSDEQSSKAKANIVVEVIAKAGAQVKFAAIDRLGENVTASVVRRGLIGDNATVDWSVGVMNDGNVVADFDSDLKGNGSHSQIKVVGISTGHQTQGIDTRVTNFGLNSVGHILQNGVILDKGTLTFNAIGHIIKGAKNADAQQSSHVLMLSDKGRGDANPILLIDENEVTAGHAASVGQVDEEDLFYLQSRGLDEETAKRLVIRGFLGSVVSEIPVKSVQAEFIETIERKLGM
>NC_022593.1|WP_023164479.1|1971942_1972713_-|Fe-S-cluster-assembly-ATPase-SufC
MATLEIKNLHVAIEGKEILKGVNLVINTNEIHAIMGPNGTGKSTLSAAIMGNPNYSVTQGEVLFDGQNVLEMSVDERARLGLFLAMQYPSEIPGITNAEFLRAAMNAKRAEDDKVSVMEFIKKLDKNMEVLSMKEEMAERYLNEGFSGGEKKRNEILQLLMLEPTFAILDEIDSGLDIDALKVVAKGVNSMRGEKFGALIITHYQRLLDYITPDVVHIMMDGRVVKTGGAELAKRLETEGYVNIAEELGLEYKEEV
>NC_022593.1|WP_023164480.1|1972887_1974219_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MVDTLKEIPFALKFLIVIIITFGISVILTPIMTFVSKAIGAVDKPNERRVNKKPMPSAGGLVIFIAFAIATLFILPHIVHNQPPIHSQPPVHGASHQPIQLVSYFSYIWPFIVGAGIVVLTGLIDDIKEISPKMKLLGLTVAASFIWFFTNARFDNLKIPFGGPLLIFPAWLSFIFTVFWILAITNAINLIDGLDGLASGVSIISLTTMGIVSYFFLPSPNVFLPITIFIMVAAIMGFFPYNYHPAIIYLGDTGALFLGFIISVASLQGLKNATAVAVLTPLLILGVPITDTIMAMVRRKLNRQSIATADKRHLHHRLMALGFTHRGAVLVIYGIASIFAFISILLQFSSRIGGILLVIACLFGLEIFIELVGILGENRQPVLKALKFVGNSSYRDKVLHSDEDADIDENEEDIGNHSMIDEEIDEPIQEFPIQNYRRSRNKK
>NC_022593.1|WP_004255173.1|1974221_1974923_-|adaptor-protein-MecA
MKYEDINENTIKITLSFDDLTDYDIKLSDFFGNQEVIEQFFYELVDELGLENRFGNVGMLTFQIQPFPQGVHMIVHEEAMLGEGGEIPDDPEEFEELMTGFYNKLNEIGADMARERGITDFKPGLGLPGTKKDEAEQEPDFIYYSIRYEDIMSVLTGIKNVKFADEESEFYRYDGNFYLVVLDNQKEKGKMHVESTRSRMMEYGEATKMSREFLQEYGECLIATRALDVLRKI
>NC_022593.1|WP_004255171.1|1975052_1975787_-|amino-acid-ABC-transporter-ATP-binding-protein
MNEYLIEIKNLHKYFGKNEVLKGLDIQIKKGEVVVMIGPSGSGKSTFLRTMNLLEKPTDGQVYFEGVNIADKSVDVFKHREKMGMVFQQFNLFPNMTVLENLCLAPVKTGKMTKEEAKKTAEDLLQRVGLSDKAEAYPQALSGGQQQRVAIARALAMNPDVMLFDEPTSALDPEMVGEVLAVMQELAKEGMTMVVVTHEMGFAKTVADRVLFMADGTIVEQGKPAQVFDSPKEKRTQDFLAKVL
>NC_022593.1|WP_004255158.1|1975786_1976473_-|amino-acid-ABC-transporter-permease
MNFDFLPKYLPYFNDGMIVTILISAFVVLIGTLLGIVTALAKISKIAPLRWLANIYIEIFRGTPMLVQIMLGFGLMGSLSLPTFQVGILQQDLGRLIPGIIVISLNSGAYMAEIVRAGIEAVPLGQKEAAYSLGIRPRQAMATVILPQALRNILPAVGNEFVTIIKDSSLLYTIGVMEVFNGAQTVANLTYQTISPMLFVALYYFVVTFVVSRLLVLFEKKLGKGYAK
>NC_022593.1|WP_023164481.1|1976620_1977529_-|diacylglycerol-kinase-family-lipid-kinase
MTYYLLANPNSGAGKGARTLETLIPYLEKNNYEYRLFKTKAAGEEGALVRQILDLKNPDDHLVIIGGDGTISLVINELPEEEAFSYIPSGSGNDFARSLKLKLDPIESFEAARRGINHEIFIMNYQSKGLSSYALNNIGIGLDATIVKSANEGKLKQVLNKLKLGSFSYILTALHVLITKKPFPALIEVENQEISLENAFLMTFTKHPYFGGGVKISPEATNENADIHLVEYNKHHLLRTFSLIPSVLRGMHLKHPLFLHRVSPQFSVELAESQPVQIDGEIHELVAADRLSISTERRMIIY

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

12923 : 76808

Bacillus_phage(16.67%)

tRNA,protease,integrase,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010905029.1\|12923_14915_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_023163553.1\|14916_15552_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-23	36.0
WP_010905031.1\|15752_16223_+	hypothetical protein	A0A097BYE2	Leuconostoc_phage	4.0e-10	30.1
WP_023163554.1\|16240_16807_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_023163555.1\|16807_20293_+	transcription-repair coupling factor	NA	NA	NA	NA
WP_003132169.1\|20451_20922_+	hypothetical protein	NA	NA	NA	NA
WP_010905034.1\|20992_21310_+	RNA-binding S4 domain-containing protein	NA	NA	NA	NA
WP_003132171.1\|21338_21713_+	septum formation initiator family protein	NA	NA	NA	NA
WP_003132172.1\|21712_22036_+	hypothetical protein	NA	NA	NA	NA
WP_023163556.1\|22173_23523_+	hypothetical protein	NA	NA	NA	NA
WP_010905037.1\|23519_24791_+\|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_010905038.1\|24771_25323_+	hypoxanthine phosphoribosyltransferase	A0A1V0SEQ1	Hokovirus	1.8e-09	29.7
WP_023163557.1\|25528_27616_+	ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein	G8DDJ2	Micromonas_pusilla_virus	5.4e-107	49.2
WP_023163558.1\|28681_30505_+	PTS mannitol transferase subunit IIB	NA	NA	NA	NA
WP_023163559.1\|30563_32501_+	transcription antiterminator	NA	NA	NA	NA
WP_003132182.1\|32548_32980_+	PTS mannitol transporter subunit IIA	NA	NA	NA	NA
WP_003132184.1\|33117_34275_+	mannitol-1-phosphate 5-dehydrogenase	NA	NA	NA	NA
WP_023163560.1\|34892_35342_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_010905065.1\|35418_35661_+	TM2 domain-containing protein	NA	NA	NA	NA
WP_023163561.1\|35741_37364_-	SulP family inorganic anion transporter	NA	NA	NA	NA
WP_010905072.1\|37573_38095_+	N-acetyltransferase	A0A1P8CWJ6	Bacillus_phage	6.0e-31	42.9
WP_023163562.1\|38558_39734_+	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_003132217.1\|39832_40588_+	DNA repair protein RecO	NA	NA	NA	NA
WP_010905074.1\|40945_42364_-	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	3.0e-40	27.0
WP_023163563.1\|42557_44156_-	dihydrolipoamide acetyltransferase	NA	NA	NA	NA
WP_010905076.1\|44148_45129_-	alpha-ketoacid dehydrogenase subunit beta	NA	NA	NA	NA
WP_023163564.1\|45131_46256_-	thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha	NA	NA	NA	NA
WP_010905078.1\|46344_47346_-	lipoate--protein ligase	NA	NA	NA	NA
WP_010905079.1\|47544_48390_-	glycerophosphodiester phosphodiesterase	A0A0S2MYI4	Enterococcus_phage	1.7e-11	31.0
WP_023163565.1\|48470_49121_-	HD domain-containing protein	A0A1S5XYU7	Kurlavirus	4.4e-15	32.4
WP_023163566.1\|49237_50263_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_010905082.1\|50764_51202_+	OsmC family peroxiredoxin	NA	NA	NA	NA
WP_023163567.1\|51362_52676_+	APC family permease	NA	NA	NA	NA
WP_010905084.1\|52735_53086_+	hypothetical protein	NA	NA	NA	NA
WP_017863956.1\|53144_54140_-	phosphate acyltransferase PlsX	NA	NA	NA	NA
WP_003132241.1\|54242_55055_-	HAD family hydrolase	NA	NA	NA	NA
WP_010905087.1\|55180_56818_-	ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	5.3e-49	25.9
WP_010905088.1\|57945_59226_-	O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase	A0A2I2L687	Orpheovirus	1.4e-09	26.9
WP_023163568.1\|59452_60286_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_010905090.1\|60686_61154_+	universal stress protein	NA	NA	NA	NA
WP_010905091.1\|61282_61480_+	DUF4649 domain-containing protein	NA	NA	NA	NA
WP_023163569.1\|61510_62131_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_010905093.1\|62181_63351_+	ring-cleaving dioxygenase	NA	NA	NA	NA
WP_003132255.1\|63361_63952_+	flavin reductase family protein	NA	NA	NA	NA
WP_023163570.1\|64549_66697_+\|bacteriocin	bacteriocin ABC transporter ATP-binding protein/permease	W8CYL7	Bacillus_phage	7.2e-38	26.5
WP_021214958.1\|68226_68364_+\|bacteriocin	bacteriocin	NA	NA	NA	NA
WP_023163572.1\|68378_69089_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_010905102.1\|69514_69967_+	transporter	NA	NA	NA	NA
WP_023163573.1\|71148_71328_-	hypothetical protein	NA	NA	NA	NA
WP_023163574.1\|71348_71528_-	hypothetical protein	NA	NA	NA	NA
WP_023163575.1\|71910_72198_+	hypothetical protein	NA	NA	NA	NA
WP_023163576.1\|72430_72613_+	hypothetical protein	NA	NA	NA	NA
WP_023163577.1\|72602_72869_+	hypothetical protein	NA	NA	NA	NA
WP_023163578.1\|72919_74158_+	glycosyltransferase	NA	NA	NA	NA
WP_003132256.1\|74377_74680_-	hypothetical protein	NA	NA	NA	NA
WP_003132257.1\|74681_74849_-\|bacteriocin	bacteriocin	NA	NA	NA	NA
WP_014571790.1\|75542_76808_-\|integrase	site-specific integrase	Q9AZK8	Lactococcus_phage	2.7e-53	35.0

DBSCAN-SWA_2

321042 : 330910

Lactococcus_phage(100.0%)

integrase

attL 320922:320946|attR 333252:333276

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
320922:320946	attL	NA	NA	NA	NA
WP_023163713.1\|321042_322239_-\|integrase	site-specific integrase	Q9AZI0	Lactococcus_phage	3.5e-127	57.4
WP_023163714.1\|322331_323009_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_014570685.1\|323166_323397_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_023163715.1\|323613_324306_+	hypothetical protein	Q9AZJ5	Lactococcus_phage	1.2e-18	47.0
WP_023163716.1\|324381_324576_+	DUF1655 domain-containing protein	Q9AZJ4	Lactococcus_phage	1.5e-27	96.9
WP_023163717.1\|324579_325101_+	hypothetical protein	Q9AZJ3	Lactococcus_phage	2.3e-70	78.9
WP_023163719.1\|325219_325372_+	hypothetical protein	Q9AZH4	Lactococcus_phage	1.7e-15	86.0
WP_023163720.1\|325368_325638_+	hypothetical protein	Q9AZH3	Lactococcus_phage	1.6e-40	98.9
WP_010906214.1\|327030_327345_+	hypothetical protein	Q9AZH1	Lactococcus_phage	3.4e-53	100.0
WP_023163722.1\|327715_327898_+	hypothetical protein	Q9AZH0	Lactococcus_phage	3.1e-27	98.3
WP_010906212.1\|327916_328123_+	hypothetical protein	Q9AZG9	Lactococcus_phage	1.6e-32	100.0
WP_023163723.1\|328284_328857_+	hypothetical protein	Q9AZG7	Lactococcus_phage	7.9e-93	94.7
WP_023163724.1\|328871_329234_+	hypothetical protein	Q9AZG6	Lactococcus_phage	9.9e-33	65.8
WP_023163726.1\|329832_330063_+	hypothetical protein	A0A1P8BME4	Lactococcus_phage	1.9e-37	96.1
WP_023163727.1\|330238_330910_+	hypothetical protein	A0A1X9IGJ1	Lactococcus_phage	3.4e-26	31.5
333252:333276	attR	NA	NA	NA	NA

DBSCAN-SWA_3

441732 : 463397

Lactococcus_phage(52.38%)

integrase

attL 433602:433621|attR 471168:471187

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
433602:433621	attL	NA	NA	NA	NA
WP_003131595.1\|441732_442050_+	thioredoxin	A0A0K2FIM3	Achromobacter_phage	4.5e-05	30.4
WP_023163753.1\|442135_442762_+	DUF4479 domain-containing protein	NA	NA	NA	NA
WP_023163754.1\|442924_444265_+	NADH oxidase	NA	NA	NA	NA
WP_023163755.1\|444354_444744_+	single-stranded DNA-binding protein	A0A0K0MWE1	Streptococcus_phage	1.8e-24	45.0
WP_003131589.1\|444863_445148_+	co-chaperone GroES	A0A221S386	uncultured_virus	3.1e-13	44.1
WP_003131585.1\|445235_446864_+	chaperonin GroEL	A0A219YK78	uncultured_virus	4.9e-156	56.8
WP_003131583.1\|446909_447722_-	MBL fold metallo-hydrolase	A0A0C5AJ83	Bacteriophage	3.1e-34	38.1
WP_010905315.1\|447892_449335_-	cell wall metabolism sensor histidine kinase WalK	W8CYF6	Bacillus_phage	1.4e-32	33.0
WP_003131580.1\|449327_450029_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.2e-42	39.7
WP_012897230.1\|450206_450842_+	dTMP kinase	M1PSC7	Streptococcus_phage	5.4e-74	65.0
WP_003131573.1\|450974_451835_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	5.0e-67	45.2
WP_010905316.1\|451886_452669_+	hypothetical protein	NA	NA	NA	NA
WP_003131570.1\|452661_452988_+	DNA replication initiation control protein YabA	NA	NA	NA	NA
WP_010905318.1\|452987_453863_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	8.7e-99	65.4
WP_003131566.1\|453939_454131_-	hypothetical protein	NA	NA	NA	NA
WP_023163756.1\|455137_455470_-	hypothetical protein	Q9AZE0	Lactococcus_phage	5.5e-38	70.4
WP_043994739.1\|455469_455781_-	hypothetical protein	NA	NA	NA	NA
WP_023163758.1\|456029_456602_-	hypothetical protein	NA	NA	NA	NA
WP_023163759.1\|456615_456930_-	hypothetical protein	NA	NA	NA	NA
WP_023163761.1\|457224_457965_-	hypothetical protein	A0A1P8BLT1	Lactococcus_phage	2.4e-41	41.7
WP_023163762.1\|457964_458729_-	replisome organizer	A0A1P8BLU3	Lactococcus_phage	1.6e-77	67.8
WP_023163763.1\|458739_459066_-	HTH domain-containing protein	Q9AZE7	Lactococcus_phage	5.2e-49	88.9
WP_023163764.1\|459052_459316_-	hypothetical protein	Q9AZE9	Lactococcus_phage	1.5e-30	73.5
WP_023163765.1\|459312_459558_-	hypothetical protein	Q9AZJ0	Lactococcus_phage	1.7e-23	67.1
WP_023163766.1\|459567_459810_-	hypothetical protein	NA	NA	NA	NA
WP_023163767.1\|459848_460118_-	hypothetical protein	Q9AZH3	Lactococcus_phage	1.3e-18	59.6
WP_023163768.1\|460114_460633_-	hypothetical protein	Q9AZJ3	Lactococcus_phage	3.1e-19	47.0
WP_023163769.1\|460637_460832_-	DUF1655 domain-containing protein	Q9AZJ4	Lactococcus_phage	5.1e-28	96.9
WP_023163770.1\|460958_461222_-	hypothetical protein	NA	NA	NA	NA
WP_023163771.1\|461259_461454_-	transcriptional regulator	NA	NA	NA	NA
WP_023163772.1\|461600_462131_+	XRE family transcriptional regulator	Q9AZN3	Lactococcus_phage	3.1e-19	71.0
WP_023163773.1\|462197_463397_+\|integrase	site-specific integrase	Q9AZI0	Lactococcus_phage	4.7e-180	79.4
471168:471187	attR	NA	NA	NA	NA

DBSCAN-SWA_4

521070 : 542031

Lactococcus_phage(85.71%)

head,protease,integrase,transposase

attL 521328:521356|attR 539291:539319

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010905402.1\|521070_521346_+	DNA-binding protein HU	A7KV42	Bacillus_phage	1.6e-22	67.4
521328:521356	attL	NA	NA	NA	NA
WP_023163786.1\|521455_522604_-\|integrase	site-specific integrase	Q9AZF9	Lactococcus_phage	3.0e-208	99.0
WP_023163787.1\|522728_523226_-	hypothetical protein	NA	NA	NA	NA
WP_023163788.1\|523244_524144_-	DNA polymerase III subunit epsilon	X2KQX9	Campylobacter_phage	1.4e-38	36.9
WP_023163789.1\|524182_524617_-	hypothetical protein	NA	NA	NA	NA
WP_023163790.1\|524626_524962_-	helix-turn-helix domain-containing protein	A0A182BQC8	Lactococcus_phage	3.0e-23	52.8
WP_023163791.1\|525257_525464_+	hypothetical protein	A0A182BQC7	Lactococcus_phage	4.6e-27	89.7
WP_010905405.1\|525478_525739_+	excisionase	Q9AZF3	Lactococcus_phage	8.6e-47	100.0
WP_023163792.1\|525898_526093_+	DUF1655 domain-containing protein	Q9AZF2	Lactococcus_phage	2.2e-26	90.6
WP_023163793.1\|526097_526523_+	hypothetical protein	Q9AZF1	Lactococcus_phage	1.8e-70	90.1
WP_023163794.1\|526557_526797_+	hypothetical protein	Q9AZF0	Lactococcus_phage	4.4e-37	96.2
WP_023163795.1\|526793_527048_+	hypothetical protein	Q9AZE9	Lactococcus_phage	1.4e-41	97.6
WP_023163796.1\|527044_527239_+	hypothetical protein	Q9AZE8	Lactococcus_phage	6.7e-28	96.9
WP_023163797.1\|527225_527552_+	hypothetical protein	Q9AZE7	Lactococcus_phage	3.5e-37	71.3
WP_003331414.1\|527747_528506_-	ATPase AAA	A0A059NT77	Lactococcus_phage	5.3e-137	100.0
WP_003331415.1\|528517_529741_-\|transposase	IS21-like element IS712 family transposase	A0A059NT83	Lactococcus_phage	4.9e-233	100.0
WP_023163800.1\|530300_531743_+	hypothetical protein	Q9AZE5	Lactococcus_phage	5.9e-270	96.9
WP_003132931.1\|532054_532456_+	hypothetical protein	Q9AZI4	Lactococcus_phage	5.1e-30	56.8
WP_010905414.1\|532611_532797_+	hypothetical protein	Q9AZE3	Lactococcus_phage	7.0e-27	100.0
WP_023163802.1\|532823_533432_+	hypothetical protein	Q9AZE2	Lactococcus_phage	4.4e-102	99.5
WP_023163803.1\|533440_534031_+\|head,protease	HK97 family phage prohead protease	Q9AZE1	Lactococcus_phage	1.1e-105	98.0
WP_023163804.1\|534246_534576_+	hypothetical protein	Q9AZE0	Lactococcus_phage	2.7e-53	100.0
WP_043994747.1\|534678_534999_+	sigma-70 family RNA polymerase sigma factor	Q9AZD9	Lactococcus_phage	3.3e-48	92.5
WP_010905419.1\|535692_535965_-	hypothetical protein	NA	NA	NA	NA
WP_010905420.1\|536081_536303_+	hypothetical protein	Q9AZD7	Lactococcus_phage	3.0e-32	100.0
WP_010905421.1\|536471_536960_+	DUF4065 domain-containing protein	Q9AZD6	Lactococcus_phage	5.0e-88	100.0
WP_010905422.1\|536925_537492_+	hypothetical protein	Q9AZD5	Lactococcus_phage	4.6e-101	100.0
WP_010905423.1\|537810_537993_+	hypothetical protein	Q9AZD4	Lactococcus_phage	5.0e-25	100.0
WP_010905424.1\|538659_538860_+	cold-shock protein	Q9AZD3	Lactococcus_phage	6.7e-31	100.0
WP_003131761.1\|539400_539898_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
539291:539319	attR	NA	NA	NA	NA
WP_003131760.1\|540044_540554_+	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	6.7e-27	42.7
WP_003131759.1\|540567_541128_+	methylphosphotriester-DNA--protein-cysteine methyltransferase family protein	NA	NA	NA	NA
WP_023163806.1\|541221_542031_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.7e-19	36.7

DBSCAN-SWA_5

956393 : 996007

Lactococcus_phage(96.08%)

holin,head,integrase,tail,transposase,portal,terminase

attL 955122:955138|attR 1000925:1000941

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
955122:955138	attL	NA	NA	NA	NA
WP_043994585.1\|956393_957527_-\|integrase	site-specific integrase	A0A059NT56	Lactococcus_phage	7.8e-193	92.8
WP_023163965.1\|957849_958716_-	hypothetical protein	NA	NA	NA	NA
WP_023163966.1\|958768_959065_-	hypothetical protein	Q9AZF7	Lactococcus_phage	2.1e-49	99.0
WP_023163967.1\|959144_959345_-	hypothetical protein	A0A1P8BMQ1	Lactococcus_phage	5.8e-27	89.4
WP_023163968.1\|959396_959831_-	hypothetical protein	NA	NA	NA	NA
WP_023163969.1\|959840_960176_-	XRE family transcriptional regulator	Q9AZF5	Lactococcus_phage	5.4e-25	53.6
WP_023163970.1\|960468_960660_+	hypothetical protein	Q9AZF4	Lactococcus_phage	4.7e-26	95.2
WP_023163971.1\|960674_961418_+	AntA/AntB antirepressor	A0A1P8BKE3	Lactococcus_phage	1.4e-129	91.9
WP_023163972.1\|961430_961763_+	DUF771 domain-containing protein	Q9AZQ3	Lactococcus_phage	3.8e-55	97.2
WP_023163975.1\|962128_962335_-	hypothetical protein	NA	NA	NA	NA
WP_023163976.1\|962337_962526_-	hypothetical protein	NA	NA	NA	NA
WP_023163977.1\|962574_962838_+	hypothetical protein	NA	NA	NA	NA
WP_023163978.1\|962927_963491_-	hypothetical protein	NA	NA	NA	NA
WP_023163979.1\|963478_963688_+	hypothetical protein	A0A1P8BLR5	Lactococcus_phage	2.0e-09	81.6
WP_023163980.1\|963677_964415_+	phage recombination protein Bet	A5GZ45	Lactococcus_phage	5.2e-137	99.6
WP_023163981.1\|964416_965484_+	DUF1351 domain-containing protein	A5GZ46	Lactococcus_phage	1.1e-169	98.0
WP_043994587.1\|965746_966673_+	DnaD domain protein	A5GZ47	Lactococcus_phage	2.9e-129	88.3
WP_023163984.1\|966665_966908_+	hypothetical protein	A5GZ49	Lactococcus_phage	2.5e-40	96.2
WP_014570810.1\|966920_967331_+	hypothetical protein	A5GZ50	Lactococcus_phage	1.3e-76	100.0
WP_023163985.1\|967438_967591_+	hypothetical protein	A0A1P8BM01	Lactococcus_phage	6.8e-20	93.9
WP_003331415.1\|967781_969005_+\|transposase	IS21-like element IS712 family transposase	A0A059NT83	Lactococcus_phage	4.9e-233	100.0
WP_003331414.1\|969016_969775_+	ATPase AAA	A0A059NT77	Lactococcus_phage	5.3e-137	100.0
WP_023163987.1\|970128_970638_+	hypothetical protein	Q9AZU7	Lactococcus_phage	1.3e-09	100.0
WP_023163988.1\|970646_970979_+	hypothetical protein	Q9G0E0	Lactococcus_phage	7.5e-11	88.2
WP_023163989.1\|970959_971226_+	hypothetical protein	NA	NA	NA	NA
WP_023163990.1\|971226_971433_+	DUF1125 domain-containing protein	Q9MC26	Lactococcus_phage	1.3e-13	58.8
WP_109009791.1\|971404_971998_+	DUF1642 domain-containing protein	Q9AZU5	Lactococcus_phage	3.6e-40	56.6
WP_023163992.1\|971994_972228_+	hypothetical protein	A0A1P8BMH6	Lactococcus_phage	8.9e-19	60.8
WP_023163993.1\|972224_972557_+	hypothetical protein	NA	NA	NA	NA
WP_023163994.1\|972546_972840_+	hypothetical protein	Q9MBV6	Lactococcus_phage	3.3e-26	84.1
WP_023163995.1\|972836_973172_+	DUF1140 family protein	A0A1B1IMW5	Lactococcus_phage	1.4e-49	90.8
WP_023163996.1\|973190_973427_+	hypothetical protein	A0A1P8BMS6	Lactococcus_phage	2.9e-09	47.5
WP_023163997.1\|973423_973624_+	hypothetical protein	A0A1P8BKA6	Lactococcus_phage	1.0e-31	90.9
WP_023163998.1\|973859_974102_+	hypothetical protein	Q8LTL7	Lactococcus_phage	1.4e-27	71.2
WP_023163999.1\|974216_974429_+	XRE family transcriptional regulator	Q9AZN3	Lactococcus_phage	1.8e-26	91.4
WP_014573151.1\|974509_974932_+	DUF722 domain-containing protein	Q9AYX5	Lactococcus_phage	5.5e-75	100.0
WP_023164000.1\|975115_975709_+	hypothetical protein	D2IYV7	Enterococcus_phage	4.9e-13	27.6
WP_023164002.1\|975880_976291_+\|terminase	terminase	Q9AZ67	Lactococcus_phage	1.6e-66	98.5
WP_023164003.1\|976283_977666_+\|terminase	terminase	Q8LTR4	Lactococcus_phage	3.4e-267	98.5
WP_023164004.1\|977686_979063_+\|portal	phage portal protein	Q9AZ65	Lactococcus_phage	8.8e-239	93.0
WP_023164005.1\|979066_980107_+	hypothetical protein	A0A1P8BM04	Lactococcus_phage	4.8e-189	97.7
WP_023164006.1\|980204_980552_-	hypothetical protein	NA	NA	NA	NA
WP_023164007.1\|980736_981366_+	DUF4355 domain-containing protein	Q9AYW7	Lactococcus_phage	1.9e-63	82.7
WP_023164008.1\|981384_982248_+	hypothetical protein	A0A1P8BKP7	Lactococcus_phage	4.2e-154	97.9
WP_080681443.1\|982247_982514_+	Ig domain-containing protein	A0A1P8BLK6	Lactococcus_phage	4.9e-21	88.7
WP_023164010.1\|982535_982868_+\|head,tail	phage head-tail connector protein	A0A1P8BMC5	Lactococcus_phage	9.3e-54	99.1
WP_023164011.1\|982864_983176_+	hypothetical protein	A0A1P8BLP2	Lactococcus_phage	1.5e-53	95.1
WP_014570728.1\|983172_983511_+	HK97 gp10 family phage protein	Q77K21	Lactococcus_phage	7.3e-54	97.3
WP_023164012.1\|983507_983897_+	hypothetical protein	A0A1P8BKT6	Lactococcus_phage	5.6e-66	99.2
WP_023164013.1\|983907_984405_+\|tail	phage major tail protein, TP901-1 family	A0A1P8BKV6	Lactococcus_phage	2.4e-85	97.0
WP_014570725.1\|984520_984856_+	hypothetical protein	Q77RZ7	Lactococcus_phage	4.2e-54	99.1
WP_043994770.1\|984951_985215_+	hypothetical protein	Q9AZ59	Lactococcus_phage	5.0e-42	100.0
WP_023164014.1\|985229_988043_+\|tail	phage tail tape measure protein	Q9G097	Lactococcus_phage	3.6e-287	96.0
WP_023164015.1\|988056_988818_+	hypothetical protein	Q9AYV7	Lactococcus_phage	8.8e-140	98.0
WP_023164016.1\|988817_991571_+	peptidase M23	A0A1P8BMA1	Lactococcus_phage	0.0e+00	96.4
WP_023164017.1\|991583_992402_+	DUF2479 domain-containing protein	A0A1L2JXK8	Streptococcus_phage	2.0e-137	88.6
WP_023164018.1\|992483_993635_+	hypothetical protein	NA	NA	NA	NA
WP_023164019.1\|993762_994068_+	hypothetical protein	A0A1P8BKN8	Lactococcus_phage	8.9e-51	96.0
WP_023164020.1\|994054_994279_+\|holin	holin	A0A059NT58	Lactococcus_phage	2.7e-28	86.5
WP_043994592.1\|995627_995831_+	hypothetical protein	A0A059NTA2	Lactococcus_phage	4.0e-15	84.3
WP_023164022.1\|995827_996007_+	hypothetical protein	Q9AZG2	Lactococcus_phage	2.3e-22	94.9
1000925:1000941	attR	NA	NA	NA	NA

DBSCAN-SWA_6

1037405 : 1051190

Enterococcus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003130964.1\|1037405_1038098_+	cell division ATP-binding protein FtsE	G9BWD6	Planktothrix_phage	2.7e-31	34.4
WP_010905664.1\|1038090_1039026_+	ABC transporter permease	NA	NA	NA	NA
WP_003130966.1\|1039127_1040105_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A096XT60	Enterococcus_phage	2.4e-118	66.2
WP_023164037.1\|1040454_1042623_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	3.0e-257	61.1
WP_003130968.1\|1042758_1043181_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A142F1R4	Bacillus_phage	2.3e-12	37.3
WP_012897612.1\|1043182_1043401_-	redoxin NrdH	C3U2K9	Lactococcus_phage	7.6e-12	47.6
WP_023164038.1\|1043574_1044216_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_003130974.1\|1044490_1046425_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	5.4e-125	43.4
WP_023164039.1\|1046629_1047169_+	cysteine hydrolase family protein	NA	NA	NA	NA
WP_023164040.1\|1047161_1047995_+	3'-5' exonuclease	A0A0K2SUJ2	Clostridium_phage	3.1e-21	39.4
WP_023164041.1\|1047991_1048441_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_043994596.1\|1048715_1051190_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	3.2e-98	32.2

DBSCAN-SWA_7

1059850 : 1068119

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023164046.1\|1059850_1060939_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	1.1e-50	38.8
WP_023164047.1\|1060938_1061589_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	6.1e-41	43.1
WP_023164048.1\|1061597_1062794_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	2.7e-111	51.3
WP_003130993.1\|1062821_1063286_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.8e-39	53.7
WP_003130994.1\|1063388_1063841_+	lipoprotein signal peptidase	NA	NA	NA	NA
WP_023164049.1\|1063901_1064807_+	RluA family pseudouridine synthase	A0A2H4UV25	Bodo_saltans_virus	7.0e-11	27.8
WP_003130996.1\|1064953_1065397_+	divergent PAP2 family protein	NA	NA	NA	NA
WP_032398531.1\|1065537_1067160_+	hypothetical protein	NA	NA	NA	NA
WP_023164050.1\|1067162_1068119_+	glycosyltransferase	I1TED8	Salmonella_phage	4.0e-49	37.5

DBSCAN-SWA_8

1671512 : 1753505

Lactococcus_phage(85.71%)

holin,tRNA,head,tail,integrase,portal,terminase

attL 1714751:1714780|attR 1751438:1751467

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_031560317.1\|1671512_1672709_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	3.9e-41	48.1
WP_023164332.1\|1672928_1673465_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_023164333.1\|1673513_1674296_-	4-hydroxy-tetrahydrodipicolinate reductase	NA	NA	NA	NA
WP_015426725.1\|1674396_1675242_-	DegV family protein	NA	NA	NA	NA
WP_015426726.1\|1675259_1675652_-	DUF1149 family protein	NA	NA	NA	NA
WP_031560327.1\|1675777_1676521_-\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_017864756.1\|1676525_1677041_-	ribosome maturation factor RimM	NA	NA	NA	NA
WP_072285314.1\|1677211_1678039_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_023164336.1\|1678179_1679124_-	ferrochelatase	NA	NA	NA	NA
WP_003130710.1\|1679385_1679625_-	KH domain-containing protein	NA	NA	NA	NA
WP_003130711.1\|1679720_1679993_-	30S ribosomal protein S16	NA	NA	NA	NA
WP_023164337.1\|1680081_1681314_-	hydroxymethylglutaryl-CoA reductase, degradative	NA	NA	NA	NA
WP_047686773.1\|1681394_1682534_-	thiolase family protein	NA	NA	NA	NA
WP_023164339.1\|1682842_1683997_+	hydroxymethylglutaryl-CoA synthase	NA	NA	NA	NA
WP_017864764.1\|1684057_1684765_-	glucosamine-6-phosphate deaminase	NA	NA	NA	NA
WP_023164340.1\|1686173_1687211_+\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_043994808.1\|1687287_1687584_-	XRE family transcriptional regulator	A0A1S5SAD3	Streptococcus_phage	6.9e-08	42.0
WP_003130730.1\|1695190_1695946_-	WxL domain-containing protein	NA	NA	NA	NA
WP_023164346.1\|1695983_1696742_-	WxL domain-containing protein	NA	NA	NA	NA
WP_080513158.1\|1696779_1697508_-	WxL domain-containing protein	NA	NA	NA	NA
WP_010906042.1\|1698505_1698601_-	hypothetical protein	NA	NA	NA	NA
WP_023164348.1\|1699420_1700038_+	hypothetical protein	NA	NA	NA	NA
WP_012898204.1\|1700051_1700222_-	hypothetical protein	NA	NA	NA	NA
WP_010906045.1\|1700249_1701557_-	GTPase ObgE	NA	NA	NA	NA
WP_023164349.1\|1701712_1702891_-	cell division protein FtsQ/DivIB	NA	NA	NA	NA
WP_023164350.1\|1702891_1703965_-	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	NA	NA	NA	NA
WP_003130748.1\|1704174_1705527_-	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	NA	NA	NA	NA
WP_010906046.1\|1706018_1706360_-	P-II family nitrogen regulator	NA	NA	NA	NA
WP_023164351.1\|1706491_1707733_-	ammonium transporter	NA	NA	NA	NA
WP_023164352.1\|1707915_1709391_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	3.0e-27	33.5
WP_003130756.1\|1709399_1710092_-	response regulator transcription factor	W8CYM9	Bacillus_phage	5.3e-35	34.1
WP_023164353.1\|1710247_1710778_-	DUF177 domain-containing protein	NA	NA	NA	NA
WP_003130760.1\|1710908_1711154_-	type B 50S ribosomal protein L31	NA	NA	NA	NA
WP_010906049.1\|1711309_1711741_-	hypothetical protein	A0A1P8BMT7	Lactococcus_phage	7.4e-11	34.3
WP_010906050.1\|1711855_1712218_-	hypothetical protein	NA	NA	NA	NA
WP_010906051.1\|1712703_1713225_-	hypothetical protein	NA	NA	NA	NA
WP_023164354.1\|1713294_1714131_-	metallophosphoesterase	NA	NA	NA	NA
1714751:1714780	attL	NA	NA	NA	NA
WP_023164022.1\|1715285_1715465_-	hypothetical protein	Q9AZG2	Lactococcus_phage	2.3e-22	94.9
WP_043994592.1\|1715461_1715665_-	hypothetical protein	A0A059NTA2	Lactococcus_phage	4.0e-15	84.3
WP_023164020.1\|1717013_1717238_-\|holin	holin	A0A059NT58	Lactococcus_phage	2.7e-28	86.5
WP_023164019.1\|1717224_1717530_-	hypothetical protein	A0A1P8BKN8	Lactococcus_phage	8.9e-51	96.0
WP_023164018.1\|1717657_1718809_-	hypothetical protein	NA	NA	NA	NA
WP_023164017.1\|1718890_1719709_-	DUF2479 domain-containing protein	A0A1L2JXK8	Streptococcus_phage	2.0e-137	88.6
WP_023164016.1\|1719721_1722475_-	peptidase M23	A0A1P8BMA1	Lactococcus_phage	0.0e+00	96.4
WP_023164015.1\|1722474_1723236_-	hypothetical protein	Q9AYV7	Lactococcus_phage	8.8e-140	98.0
WP_023164355.1\|1723249_1726063_-\|tail	phage tail tape measure protein	Q9G097	Lactococcus_phage	3.0e-286	95.9
WP_043994770.1\|1726077_1726341_-	hypothetical protein	Q9AZ59	Lactococcus_phage	5.0e-42	100.0
WP_014570725.1\|1726436_1726772_-	hypothetical protein	Q77RZ7	Lactococcus_phage	4.2e-54	99.1
WP_023164013.1\|1726887_1727385_-\|tail	phage major tail protein, TP901-1 family	A0A1P8BKV6	Lactococcus_phage	2.4e-85	97.0
WP_023164012.1\|1727395_1727785_-	hypothetical protein	A0A1P8BKT6	Lactococcus_phage	5.6e-66	99.2
WP_014570728.1\|1727781_1728120_-	HK97 gp10 family phage protein	Q77K21	Lactococcus_phage	7.3e-54	97.3
WP_023164011.1\|1728116_1728428_-	hypothetical protein	A0A1P8BLP2	Lactococcus_phage	1.5e-53	95.1
WP_023164010.1\|1728424_1728757_-\|head,tail	phage head-tail connector protein	A0A1P8BMC5	Lactococcus_phage	9.3e-54	99.1
WP_080681443.1\|1728778_1729045_-	Ig domain-containing protein	A0A1P8BLK6	Lactococcus_phage	4.9e-21	88.7
WP_023164008.1\|1729044_1729908_-	hypothetical protein	A0A1P8BKP7	Lactococcus_phage	4.2e-154	97.9
WP_023164007.1\|1729926_1730556_-	DUF4355 domain-containing protein	Q9AYW7	Lactococcus_phage	1.9e-63	82.7
WP_023164006.1\|1730740_1731088_+	hypothetical protein	NA	NA	NA	NA
WP_023164005.1\|1731185_1732226_-	hypothetical protein	A0A1P8BM04	Lactococcus_phage	4.8e-189	97.7
WP_023164004.1\|1732229_1733606_-\|portal	phage portal protein	Q9AZ65	Lactococcus_phage	8.8e-239	93.0
WP_023164003.1\|1733626_1735009_-\|terminase	terminase	Q8LTR4	Lactococcus_phage	3.4e-267	98.5
WP_023164002.1\|1735001_1735412_-\|terminase	terminase	Q9AZ67	Lactococcus_phage	1.6e-66	98.5
WP_023164000.1\|1735583_1736177_-	hypothetical protein	D2IYV7	Enterococcus_phage	4.9e-13	27.6
WP_014573151.1\|1736360_1736783_-	DUF722 domain-containing protein	Q9AYX5	Lactococcus_phage	5.5e-75	100.0
WP_023164356.1\|1736863_1737076_-	XRE family transcriptional regulator	Q9AZN3	Lactococcus_phage	4.7e-27	92.9
WP_023163998.1\|1737190_1737433_-	hypothetical protein	Q8LTL7	Lactococcus_phage	1.4e-27	71.2
WP_023164358.1\|1737857_1738022_-	hypothetical protein	Q94M83	Lactococcus_phage	9.4e-07	48.4
WP_023164359.1\|1738018_1738162_-	hypothetical protein	A0A1P8BMD9	Lactococcus_phage	4.6e-18	97.9
WP_023164360.1\|1738208_1738889_-	hypothetical protein	A5GYP2	Lactococcus_phage	1.7e-126	97.3
WP_023164361.1\|1738885_1739125_-	hypothetical protein	A0A1W6JL86	Lactococcus_phage	7.5e-13	49.3
WP_109009800.1\|1739114_1739303_-	hypothetical protein	Q77MW5	Lactococcus_phage	7.2e-19	92.0
WP_023164363.1\|1739744_1740020_-	hypothetical protein	A0A1P8BLI3	Lactococcus_phage	5.5e-44	92.0
WP_023164364.1\|1740022_1740442_-	dUTP diphosphatase	A0A1P8BMQ4	Lactococcus_phage	4.3e-72	97.1
WP_023164365.1\|1740438_1740678_-	hypothetical protein	NA	NA	NA	NA
WP_023164366.1\|1740674_1740995_-	hypothetical protein	V9VEU7	Lactococcus_phage	6.9e-46	83.7
WP_023164367.1\|1740991_1741684_-	DUF1642 domain-containing protein	Q9AZU5	Lactococcus_phage	1.2e-42	49.8
WP_043994640.1\|1741699_1741948_-	hypothetical protein	A0A1P8BLV4	Lactococcus_phage	2.2e-15	59.8
WP_014570535.1\|1741956_1742163_-	hypothetical protein	Q9MC28	Lactococcus_phage	4.8e-32	100.0
WP_023164370.1\|1742495_1742660_-	hypothetical protein	A0A1P8BKY2	Lactococcus_phage	5.5e-23	98.1
WP_023164371.1\|1742668_1743559_-	prepilin peptidase	Q38098	Lactococcus_phage	1.0e-163	99.7
WP_023164372.1\|1743568_1744375_-	replication protein	A0A1P8BL25	Lactococcus_phage	4.4e-57	98.1
WP_023164373.1\|1744602_1745379_-	hypothetical protein	Q9AZP9	Lactococcus_phage	6.0e-144	97.7
WP_023164374.1\|1745378_1746185_-	hypothetical protein	Q9AZQ0	Lactococcus_phage	4.3e-137	94.8
WP_023164375.1\|1746284_1746527_-	hypothetical protein	A0A1B1IMF7	Lactococcus_phage	7.1e-35	93.8
WP_023164376.1\|1746529_1746799_-	hypothetical protein	A0A059NT46	Lactococcus_phage	5.1e-34	96.1
WP_021214422.1\|1746878_1747217_-	hypothetical protein	A0A1B1IMQ1	Lactococcus_phage	2.6e-59	100.0
WP_023164377.1\|1747230_1747968_-	AntA/AntB antirepressor	A0A1P8BKE3	Lactococcus_phage	2.5e-139	99.2
WP_003129906.1\|1747979_1748222_-	hypothetical protein	Q77JL3	Lactococcus_phage	2.0e-37	97.5
WP_023164378.1\|1748375_1748846_+	hypothetical protein	NA	NA	NA	NA
WP_043994642.1\|1749306_1750143_+	helix-turn-helix domain-containing protein	Q9AZQ8	Lactococcus_phage	1.9e-156	98.9
WP_023164381.1\|1750192_1751332_+\|integrase	site-specific integrase	A0A1B1IMP1	Lactococcus_phage	9.2e-210	97.9
WP_003129376.1\|1751436_1752510_-	carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	1.5e-60	35.3
1751438:1751467	attR	NA	NA	NA	NA
WP_023164382.1\|1752572_1753505_-	aspartate carbamoyltransferase catalytic subunit	M1HWF9	Paramecium_bursaria_Chlorella_virus	1.8e-22	30.2

DBSCAN-SWA_9

1879310 : 1889088

Prochlorococcus_phage(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003130886.1\|1879310_1880072_-	phosphate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.5e-17	30.0
WP_003130885.1\|1880237_1881047_-	phosphate ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.0e-10	26.5
WP_003130884.1\|1881080_1881974_-	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_021722156.1\|1881973_1882897_-	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_017864882.1\|1883017_1883869_-	phosphate ABC transporter substrate-binding protein	E3SNT9	Prochlorococcus_phage	4.2e-05	27.3
WP_003130880.1\|1884215_1885112_-	phosphate ABC transporter substrate-binding protein	E3SM63	Prochlorococcus_phage	7.2e-08	32.4
WP_023164435.1\|1885389_1885857_-	SsrA-binding protein SmpB	W5RAM5	Staphylococcus_phage	4.7e-43	56.6
WP_023164436.1\|1885888_1886383_-	esterase	NA	NA	NA	NA
WP_023164437.1\|1886469_1889088_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	4.2e-64	33.3

DBSCAN-SWA_10

1903851 : 1920058

Lactococcus_phage(88.24%)

integrase

attL 1902059:1902074|attR 1916309:1916324

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1902059:1902074	attL	NA	NA	NA	NA
WP_023164445.1\|1903851_1905264_-	hypothetical protein	V9QJ85	Oenococcus_phage	1.1e-07	23.0
WP_080681476.1\|1905566_1905686_-	GNAT family acetyltransferase	NA	NA	NA	NA
WP_023164447.1\|1905715_1906105_-	hypothetical protein	NA	NA	NA	NA
WP_023164448.1\|1906663_1906900_-	hypothetical protein	A0A1P8BLF8	Lactococcus_phage	1.6e-12	70.2
WP_023164449.1\|1906997_1907228_-	hypothetical protein	A0A1P8BME4	Lactococcus_phage	2.5e-37	94.7
WP_023164451.1\|1907839_1908202_-	hypothetical protein	Q9AZG6	Lactococcus_phage	3.9e-29	61.7
WP_023164452.1\|1908217_1908790_-	hypothetical protein	Q9AZG7	Lactococcus_phage	1.8e-92	94.7
WP_010906212.1\|1908951_1909158_-	hypothetical protein	Q9AZG9	Lactococcus_phage	1.6e-32	100.0
WP_003132807.1\|1909176_1909359_-	hypothetical protein	Q9AZH0	Lactococcus_phage	5.3e-27	98.3
WP_080554626.1\|1909728_1910043_-	hypothetical protein	Q9AZH1	Lactococcus_phage	4.1e-51	94.2
WP_023164454.1\|1911435_1911705_-	hypothetical protein	Q9AZH3	Lactococcus_phage	3.6e-40	98.9
WP_023163719.1\|1911701_1911854_-	hypothetical protein	Q9AZH4	Lactococcus_phage	1.7e-15	86.0
WP_011675324.1\|1912035_1912206_-	DUF1655 domain-containing protein	Q9AZH6	Lactococcus_phage	5.1e-24	94.6
WP_058217209.1\|1912276_1912414_-	hypothetical protein	Q9AZH7	Lactococcus_phage	4.0e-11	89.7
WP_023164457.1\|1913071_1913263_-	XRE family transcriptional regulator	R9QNG3	Lactococcus_phage	4.6e-21	79.4
WP_023164458.1\|1913261_1913900_+	XRE family transcriptional regulator	R9QMZ5	Lactococcus_phage	1.4e-08	30.6
WP_023164459.1\|1913974_1915186_+\|integrase	site-specific integrase	Q9AZI0	Lactococcus_phage	1.2e-117	54.6
WP_023164460.1\|1915306_1916221_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	1.9e-11	26.1
WP_003132795.1\|1916377_1916890_-	HD domain-containing protein	NA	NA	NA	NA
1916309:1916324	attR	NA	NA	NA	NA
WP_010906113.1\|1917222_1917456_+	30S ribosomal protein S20	NA	NA	NA	NA
WP_023164461.1\|1917553_1920058_-	ATP-dependent RecD-like DNA helicase	A0A1W6JK95	Lactococcus_phage	1.2e-44	25.9

DBSCAN-SWA_11

2037788 : 2118530

Lactococcus_phage(74.14%)

holin,tRNA,capsid,head,tail,integrase,protease,portal,terminase

attL 2077671:2077693|attR 2118550:2118572

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010906168.1\|2037788_2039135_-\|tRNA	cysteine--tRNA ligase	A0A2K9V966	Bandra_megavirus	3.1e-47	29.5
WP_012898419.1\|2039147_2039741_-	DUF1211 domain-containing protein	NA	NA	NA	NA
WP_003132365.1\|2039754_2040354_-	serine O-acetyltransferase	NA	NA	NA	NA
WP_003132366.1\|2040460_2041231_-	hypothetical protein	NA	NA	NA	NA
WP_003132367.1\|2041439_2043761_-	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
WP_023164495.1\|2044044_2045190_-	hypothetical protein	NA	NA	NA	NA
WP_012898422.1\|2045554_2046520_+	ribose-phosphate diphosphokinase	A0A2K9L2G2	Tupanvirus	1.0e-36	32.8
WP_010906170.1\|2046641_2047073_-	universal stress protein	NA	NA	NA	NA
WP_043994672.1\|2047312_2048440_+	cysteine desulfurase	H7BUW1	unidentified_phage	2.9e-30	36.4
WP_003132372.1\|2048463_2048808_+	cysteine desulfurase	NA	NA	NA	NA
WP_003132374.1\|2048898_2050086_-	elongation factor Tu	A0A076FFS6	Aureococcus_anophage	2.0e-34	29.4
WP_003132378.1\|2050328_2050511_+	hypothetical protein	NA	NA	NA	NA
WP_014570713.1\|2050569_2050686_+	DUF4044 domain-containing protein	NA	NA	NA	NA
WP_023164497.1\|2050743_2053542_-\|tRNA	isoleucine--tRNA ligase	A0A1V0SJ93	Klosneuvirus	4.8e-82	25.9
WP_003132384.1\|2053857_2054784_-	DivIVA domain-containing protein	NA	NA	NA	NA
WP_010906173.1\|2054840_2055632_-	cell division protein	NA	NA	NA	NA
WP_010906174.1\|2055628_2055904_-	YggT family protein	NA	NA	NA	NA
WP_003132390.1\|2055903_2056494_-	cell division protein SepF	NA	NA	NA	NA
WP_043994675.1\|2056537_2057206_-	YggS family pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_003132392.1\|2057209_2058463_-	cell division protein FtsZ	NA	NA	NA	NA
WP_023164498.1\|2058493_2059864_-	cell division protein FtsA	NA	NA	NA	NA
WP_010906175.1\|2060024_2060894_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	3.8e-14	35.3
WP_012898430.1\|2061006_2061735_-	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	A0A2D1A6G0	Rhodococcus_phage	5.5e-06	27.2
WP_010906176.1\|2061880_2062999_-	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_023164499.1\|2063129_2063975_-	aldo/keto reductase	A0A1V0SDE7	Indivirus	4.8e-30	32.9
WP_003132399.1\|2063986_2065315_-	MFS transporter	NA	NA	NA	NA
WP_021722576.1\|2065480_2066359_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_003130788.1\|2066374_2066779_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_010906180.1\|2066860_2068171_-	aminopeptidase C	R4TV59	Phaeocystis_globosa_virus	9.7e-62	31.5
WP_023164501.1\|2068299_2068893_-	HD domain-containing protein	NA	NA	NA	NA
WP_003130794.1\|2068950_2069631_-	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	NA	NA	NA	NA
WP_003130796.1\|2069662_2069941_-	hypothetical protein	NA	NA	NA	NA
WP_012898439.1\|2069933_2070518_-	NUDIX hydrolase	NA	NA	NA	NA
WP_003130798.1\|2070622_2071999_-	bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU	A0A0G2Y8M0	Acanthamoeba_polyphaga_mimivirus	7.1e-31	35.3
WP_012898440.1\|2072226_2073015_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.7e-32	33.6
WP_010906184.1\|2073093_2073363_-	30S ribosomal protein S15	NA	NA	NA	NA
WP_003130801.1\|2073544_2075428_-	Stk1 family PASTA domain-containing Ser/Thr kinase	A0A1V0SDC3	Indivirus	3.1e-21	31.6
WP_003130802.1\|2075427_2076204_-	Stp1/IreP family PP2C-type Ser/Thr phosphatase	NA	NA	NA	NA
WP_014570715.1\|2076284_2077559_-	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	NA	NA	NA	NA
2077671:2077693	attL	NA	NA	NA	NA
WP_109009802.1\|2078193_2078370_+	hypothetical protein	A5GYL5	Lactococcus_phage	2.3e-19	85.7
WP_023164503.1\|2078485_2078908_-	hypothetical protein	NA	NA	NA	NA
WP_023164504.1\|2078907_2079210_-	hypothetical protein	NA	NA	NA	NA
WP_023164505.1\|2079223_2079751_-	hypothetical protein	NA	NA	NA	NA
WP_023164506.1\|2079943_2080723_-	muramidase	Q38323	Lactococcus_phage	1.5e-126	98.5
WP_023164507.1\|2080722_2081010_-\|holin	phage holin	Q9AZL0	Lactococcus_phage	1.6e-46	98.9
WP_023164508.1\|2081022_2081373_-	hypothetical protein	A0A1P8BKU2	Lactococcus_phage	2.0e-54	99.1
WP_023164509.1\|2081385_2081616_-	hypothetical protein	NA	NA	NA	NA
WP_023164511.1\|2085645_2087181_-	hypothetical protein	Q9AZL3	Lactococcus_phage	1.5e-101	43.3
WP_043994676.1\|2087180_2091314_-	hypothetical protein	Q9AZL4	Lactococcus_phage	7.0e-199	89.2
WP_023164513.1\|2091483_2091834_-	hypothetical protein	NA	NA	NA	NA
WP_023164514.1\|2091893_2092499_-\|tail	tail protein	Q9AZL7	Lactococcus_phage	1.3e-106	97.5
WP_010905383.1\|2092500_2092896_-	DUF806 family protein	Q9AZL8	Lactococcus_phage	1.4e-67	100.0
WP_043994677.1\|2092892_2093378_-	hypothetical protein	Q9AZL9	Lactococcus_phage	2.0e-84	99.4
WP_010905381.1\|2093374_2093710_-\|head,tail	head-tail adaptor protein	Q9AZM0	Lactococcus_phage	5.9e-56	100.0
WP_010905380.1\|2093696_2094002_-	hypothetical protein	Q9AZM1	Lactococcus_phage	4.4e-50	100.0
WP_023164516.1\|2094012_2095326_-\|capsid	phage major capsid protein	Q9AZM2	Lactococcus_phage	1.1e-187	90.8
WP_023164517.1\|2095315_2095903_-\|head,protease	HK97 family phage prohead protease	Q9AZM3	Lactococcus_phage	2.4e-105	98.5
WP_023164518.1\|2095902_2096982_-\|portal	phage portal protein	Q9AZM4	Lactococcus_phage	1.2e-198	99.7
WP_023164519.1\|2096978_2097143_-	hypothetical protein	Q9AZM5	Lactococcus_phage	5.7e-20	96.3
WP_023164520.1\|2097151_2098966_-\|terminase	terminase large subunit	Q9AZM6	Lactococcus_phage	0.0e+00	99.8
WP_023164521.1\|2098965_2099358_-\|terminase	phage terminase small subunit P27 family	Q9AZM7	Lactococcus_phage	6.8e-19	38.9
WP_014573150.1\|2099554_2100058_-	HNH endonuclease	Q9AZM8	Lactococcus_phage	1.2e-92	99.4
WP_015966900.1\|2100341_2100764_-	DUF722 domain-containing protein	Q9AZ68	Lactococcus_phage	5.0e-52	100.0
WP_023164523.1\|2100844_2101057_-	XRE family transcriptional regulator	Q9AZN3	Lactococcus_phage	1.1e-28	97.1
WP_023164524.1\|2101028_2101349_-	DUF1359 domain-containing protein	Q9AZZ2	Lactococcus_phage	5.5e-43	91.7
WP_023164172.1\|2102368_2103157_+	peptide transporter	Q7M293	Enterobacteria_phage	5.2e-10	27.3
WP_023164358.1\|2103773_2103938_-	hypothetical protein	Q94M83	Lactococcus_phage	9.4e-07	48.4
WP_023164359.1\|2103934_2104078_-	hypothetical protein	A0A1P8BMD9	Lactococcus_phage	4.6e-18	97.9
WP_023164360.1\|2104124_2104805_-	hypothetical protein	A5GYP2	Lactococcus_phage	1.7e-126	97.3
WP_023164361.1\|2104801_2105041_-	hypothetical protein	A0A1W6JL86	Lactococcus_phage	7.5e-13	49.3
WP_109009800.1\|2105030_2105219_-	hypothetical protein	Q77MW5	Lactococcus_phage	7.2e-19	92.0
WP_023164525.1\|2105608_2106028_-	dUTP diphosphatase	Q9AYX8	Lactococcus_phage	2.5e-72	99.3
WP_023164526.1\|2106024_2106588_-	DUF1642 domain-containing protein	Q9AYX9	Lactococcus_phage	7.1e-70	74.6
WP_021037750.1\|2106580_2106763_-	hypothetical protein	NA	NA	NA	NA
WP_023164527.1\|2106826_2107459_+	hypothetical protein	NA	NA	NA	NA
WP_011835825.1\|2107473_2107671_-	DUF1125 domain-containing protein	NA	NA	NA	NA
WP_043994683.1\|2107667_2107874_-	hypothetical protein	NA	NA	NA	NA
WP_014570535.1\|2107882_2108089_-	hypothetical protein	Q9MC28	Lactococcus_phage	4.8e-32	100.0
WP_080681458.1\|2108196_2108673_-	hypothetical protein	A5GZ50	Lactococcus_phage	4.1e-71	92.6
WP_023164530.1\|2108596_2108761_-	hypothetical protein	A0A1P8BKY2	Lactococcus_phage	5.5e-23	98.1
WP_023164371.1\|2108770_2109661_-	prepilin peptidase	Q38098	Lactococcus_phage	1.0e-163	99.7
WP_023164531.1\|2109670_2110432_-	DNA replication protein	A0A1P8BKE9	Lactococcus_phage	4.0e-108	79.1
WP_023164532.1\|2110556_2110982_-	single-stranded DNA-binding protein	Q9MC32	Lactococcus_phage	3.6e-74	98.6
WP_023164533.1\|2110974_2111733_-	recombinase	Q0ILF6	Lactococcus_phage	3.4e-144	97.6
WP_010905688.1\|2111741_2112260_-	hypothetical protein	Q9XJE3	Lactococcus_phage	6.3e-89	100.0
WP_010905687.1\|2112375_2112591_-	DUF1408 domain-containing protein	Q38272	Lactococcus_phage	2.4e-34	100.0
WP_011834777.1\|2112693_2112972_+	hypothetical protein	A0A059NT68	Lactococcus_phage	1.1e-47	100.0
WP_023164535.1\|2112926_2113160_-	hypothetical protein	A0A059NT46	Lactococcus_phage	1.2e-34	98.7
WP_023164536.1\|2113252_2113522_-	hypothetical protein	NA	NA	NA	NA
WP_023164537.1\|2113534_2114293_-	antirepressor	A0A1B1IMQ3	Lactococcus_phage	2.5e-118	86.2
WP_011835843.1\|2114304_2114553_-	XRE family transcriptional regulator	J7KK54	Streptococcus_phage	2.2e-07	51.7
WP_015966961.1\|2114655_2114922_+	hypothetical protein	Q38335	Lactococcus_phage	7.0e-44	100.0
WP_023164538.1\|2114915_2115110_-	hypothetical protein	NA	NA	NA	NA
WP_023164540.1\|2115465_2115699_-	hypothetical protein	Q9AZQ6	Lactococcus_phage	1.8e-35	94.8
WP_023164541.1\|2115994_2116492_+	helix-turn-helix domain-containing protein	J7KJ52	Streptococcus_phage	1.3e-22	50.4
WP_023164542.1\|2116497_2116932_+	zinc peptidase	NA	NA	NA	NA
WP_014573177.1\|2116945_2117281_+	hypothetical protein	NA	NA	NA	NA
WP_023164543.1\|2117348_2118530_+\|integrase	site-specific integrase	Q9AZK8	Lactococcus_phage	1.3e-89	47.2
2118550:2118572	attR	NA	NA	NA	NA

DBSCAN-SWA_12

2217534 : 2230575

Lactococcus_phage(94.12%)

integrase

attL 2216834:2216851|attR 2230662:2230679

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2216834:2216851	attL	NA	NA	NA	NA
WP_023164569.1\|2217534_2217855_-	sigma-70 family RNA polymerase sigma factor	Q9AZD9	Lactococcus_phage	1.3e-49	95.3
WP_023164570.1\|2217957_2218287_-	hypothetical protein	Q9AZE0	Lactococcus_phage	7.3e-51	94.5
WP_023164571.1\|2218431_2220066_-	DNA primase	Q9AZI5	Lactococcus_phage	1.2e-287	90.0
WP_023164572.1\|2220076_2220871_-	hypothetical protein	Q9AZI6	Lactococcus_phage	1.2e-144	91.7
WP_023164573.1\|2220874_2221204_-	hypothetical protein	Q9AZI7	Lactococcus_phage	1.2e-53	94.4
WP_014570844.1\|2221200_2221512_-	hypothetical protein	NA	NA	NA	NA
WP_023164574.1\|2221508_2221763_-	hypothetical protein	Q9AZE9	Lactococcus_phage	1.4e-36	86.7
WP_023164575.1\|2221759_2221999_-	hypothetical protein	Q9AZJ0	Lactococcus_phage	2.6e-37	96.2
WP_023164576.1\|2222041_2222323_-	hypothetical protein	Q9AZJ1	Lactococcus_phage	8.7e-45	94.6
WP_023164578.1\|2222468_2222999_-	hypothetical protein	Q9AZJ3	Lactococcus_phage	1.5e-50	63.1
WP_023164579.1\|2222995_2223193_-	DUF1655 domain-containing protein	Q9AZF2	Lactococcus_phage	5.4e-25	93.4
WP_023164580.1\|2223207_2223429_-	hypothetical protein	NA	NA	NA	NA
WP_101913874.1\|2223642_2223819_-	CopG family transcriptional regulator	NA	NA	NA	NA
WP_023164582.1\|2224082_2224772_-	hypothetical protein	R9QNB1	Lactococcus_phage	6.2e-92	79.1
WP_023164583.1\|2224947_2225139_-	hypothetical protein	R9QNG3	Lactococcus_phage	4.9e-23	85.7
WP_023164584.1\|2225277_2225742_+	helix-turn-helix domain-containing protein	R9QMZ5	Lactococcus_phage	4.4e-09	36.4
WP_023164585.1\|2225807_2226002_+	hypothetical protein	Q9AZK1	Lactococcus_phage	1.5e-27	95.3
WP_014734881.1\|2226290_2226548_+	hypothetical protein	NA	NA	NA	NA
WP_023164587.1\|2226828_2227725_+	hypothetical protein	A3QSC6	Clostridium_virus	8.2e-44	33.3
WP_023164588.1\|2228781_2228946_+	hypothetical protein	Q9AZK6	Lactococcus_phage	2.1e-19	90.7
WP_023164589.1\|2229393_2230575_+\|integrase	site-specific integrase	Q9AZK8	Lactococcus_phage	7.6e-90	45.5
2230662:2230679	attR	NA	NA	NA	NA

DBSCAN-SWA_13

2339902 : 2382013

Lactococcus_phage(93.33%)

capsid,holin,transposase,portal

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023164616.1\|2339902_2340682_-	muramidase	Q38323	Lactococcus_phage	3.3e-126	98.1
WP_023164507.1\|2340681_2340969_-\|holin	phage holin	Q9AZL0	Lactococcus_phage	1.6e-46	98.9
WP_023164617.1\|2340994_2342557_-	DUF2479 domain-containing protein	Q9AZR3	Lactococcus_phage	7.1e-245	96.0
WP_011676503.1\|2342568_2342793_-\|holin	holin	A0A1B1IMU8	Lactococcus_phage	6.1e-33	100.0
WP_023164509.1\|2342805_2343036_-	hypothetical protein	NA	NA	NA	NA
WP_023164618.1\|2343047_2346080_-	hypothetical protein	A0A1B1IMK1	Lactococcus_phage	4.9e-282	57.8
WP_023164619.1\|2346079_2347603_-	hypothetical protein	A0A1B1IM42	Lactococcus_phage	1.3e-81	37.1
WP_003331415.1\|2348810_2350034_+\|transposase	IS21-like element IS712 family transposase	A0A059NT83	Lactococcus_phage	4.9e-233	100.0
WP_003331414.1\|2350045_2350804_+	ATPase AAA	A0A059NT77	Lactococcus_phage	5.3e-137	100.0
WP_023164622.1\|2352379_2353087_-	hypothetical protein	A5GYM7	Lactococcus_phage	6.9e-123	99.1
WP_003131323.1\|2353102_2353510_-	hypothetical protein	A0A1B1IMQ4	Lactococcus_phage	1.2e-66	100.0
WP_014570559.1\|2353566_2354043_-	hypothetical protein	A5GYM5	Lactococcus_phage	3.0e-85	100.0
WP_023164623.1\|2354053_2354488_-	hypothetical protein	A5GYM4	Lactococcus_phage	7.4e-75	99.3
WP_003131320.1\|2354487_2354817_-	hypothetical protein	A5GYM3	Lactococcus_phage	4.4e-56	100.0
WP_014570557.1\|2354813_2355158_-	hypothetical protein	A5GYM2	Lactococcus_phage	3.1e-60	100.0
WP_014570556.1\|2355147_2355549_-	hypothetical protein	A5GYM1	Lactococcus_phage	6.8e-59	100.0
WP_014570555.1\|2355622_2355859_-	Ig domain-containing protein	A5GYM0	Lactococcus_phage	4.2e-32	100.0
WP_023164624.1\|2355887_2356805_-\|capsid	phage capsid protein	A5GYL9	Lactococcus_phage	1.4e-163	99.0
WP_023164625.1\|2356820_2357870_-	DNA methyltransferase	A0A1B1IMM2	Lactococcus_phage	8.4e-157	94.0
WP_023164626.1\|2357885_2358716_-\|capsid	phage capsid protein	A0A1B1IM23	Lactococcus_phage	7.1e-151	98.2
WP_023164627.1\|2358708_2360238_-\|portal	phage portal protein	A5GYL6	Lactococcus_phage	3.2e-290	99.0
WP_109009804.1\|2360250_2361693_-	hypothetical protein	A5GYP8	Lactococcus_phage	1.5e-281	99.0
WP_023164629.1\|2361682_2362492_-	HNH endonuclease	A0A1X9I5J3	Streptococcus_phage	1.1e-79	55.9
WP_023164630.1\|2362663_2363053_-	DUF722 domain-containing protein	A5GYP6	Lactococcus_phage	6.0e-68	97.7
WP_023164631.1\|2363416_2363638_-	hypothetical protein	A0A1P8BL06	Lactococcus_phage	1.9e-34	98.6
WP_023164632.1\|2363646_2363841_-	hypothetical protein	Q9AZT9	Lactococcus_phage	2.8e-34	96.9
WP_023164633.1\|2363837_2364047_-	hypothetical protein	E0YIV8	Lactococcus_phage	4.4e-33	98.6
WP_023164634.1\|2364047_2364263_-	hypothetical protein	E0YIV7	Lactococcus_phage	1.1e-34	93.0
WP_023164635.1\|2364309_2364504_-	hypothetical protein	A0A1W6JL55	Lactococcus_phage	5.3e-17	68.8
WP_023164636.1\|2364520_2365171_-	hypothetical protein	A0A1P8BL14	Lactococcus_phage	5.4e-122	98.6
WP_043994700.1\|2365157_2365487_-	hypothetical protein	A0A1W6JKT3	Lactococcus_phage	3.3e-27	64.7
WP_109009806.1\|2365804_2365984_-	hypothetical protein	A0A0D3MT42	Lactococcus_phage	7.1e-24	88.1
WP_109009808.1\|2366070_2366256_-	hypothetical protein	A0A1P8BKA8	Lactococcus_phage	4.0e-22	93.4
WP_023164641.1\|2366566_2367475_-	DnaD domain protein	Q8LTN2	Lactococcus_phage	1.7e-41	69.5
WP_023164642.1\|2367702_2368773_-	DUF1351 domain-containing protein	A5GZ46	Lactococcus_phage	6.1e-139	86.3
WP_023164643.1\|2368774_2369641_-	hypothetical protein	A0A286QQF5	Streptococcus_phage	2.6e-39	43.4
WP_023164644.1\|2369746_2369923_-	hypothetical protein	A0A059NT92	Lactococcus_phage	5.3e-24	94.8
WP_023164645.1\|2369919_2370168_-	hypothetical protein	A5GZ43	Lactococcus_phage	1.0e-33	93.9
WP_003130605.1\|2370299_2370482_-	hypothetical protein	A5GZ68	Lactococcus_phage	2.4e-27	100.0
WP_080681481.1\|2370497_2371148_-	hypothetical protein	A0A1P8BKT1	Lactococcus_phage	1.7e-112	94.9
WP_023164648.1\|2371266_2371476_-	XRE family transcriptional regulator	A0A1P8BKS6	Lactococcus_phage	1.5e-33	100.0
WP_023164649.1\|2371668_2372094_+	XRE family transcriptional regulator	A0A1B1IMJ4	Lactococcus_phage	8.5e-76	100.0
WP_023164650.1\|2372104_2372689_+	hypothetical protein	A0A1B1ILZ7	Lactococcus_phage	2.5e-110	96.9
WP_023164651.1\|2372744_2373284_+	hypothetical protein	A5GZ63	Lactococcus_phage	2.8e-92	99.4
WP_023164652.1\|2373403_2374861_+	recombinase family protein	A0A1B1IM01	Lactococcus_phage	2.8e-275	99.4
WP_010906319.1\|2375011_2376085_-	type II secretion system F family protein	NA	NA	NA	NA
WP_031561106.1\|2375978_2376917_-	type II/IV secretion system protein	NA	NA	NA	NA
WP_023164655.1\|2377036_2382013_-	PolC-type DNA polymerase III	A0A0K2SUJ2	Clostridium_phage	1.6e-19	37.2

DBSCAN-SWA_14

2466374 : 2483381

Lactococcus_phage(88.89%)

head,bacteriocin,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010905061.1\|2466374_2466539_-\|bacteriocin	bacteriocin	Q9AZK6	Lactococcus_phage	7.9e-22	100.0
WP_023164684.1\|2467962_2468403_-	hypothetical protein	NA	NA	NA	NA
WP_023164685.1\|2468399_2469395_-	hypothetical protein	NA	NA	NA	NA
WP_023164686.1\|2469484_2469679_-	hypothetical protein	Q9AZK1	Lactococcus_phage	6.7e-28	96.9
WP_023164688.1\|2470016_2470643_-	XRE family transcriptional regulator	A0A1P8BMG3	Lactococcus_phage	4.3e-15	44.8
WP_023164689.1\|2470925_2471132_+	XRE family transcriptional regulator	NA	NA	NA	NA
WP_023164690.1\|2471133_2471412_+	hypothetical protein	NA	NA	NA	NA
WP_043994704.1\|2471411_2471585_+	hypothetical protein	A0A1B1IMG1	Lactococcus_phage	4.4e-23	94.7
WP_023163716.1\|2471767_2471962_+	DUF1655 domain-containing protein	Q9AZJ4	Lactococcus_phage	1.5e-27	96.9
WP_023164692.1\|2471966_2472578_+	hypothetical protein	Q9AZJ3	Lactococcus_phage	5.0e-45	61.6
WP_023164693.1\|2472570_2472852_+	hypothetical protein	Q9AZJ1	Lactococcus_phage	5.1e-45	93.5
WP_023164694.1\|2472894_2473134_+	hypothetical protein	Q9AZJ0	Lactococcus_phage	4.8e-36	92.4
WP_023164695.1\|2473130_2473385_+	hypothetical protein	Q9AZE9	Lactococcus_phage	1.8e-36	88.0
WP_023164696.1\|2473381_2473693_+	hypothetical protein	NA	NA	NA	NA
WP_023164573.1\|2473689_2474019_+	hypothetical protein	Q9AZI7	Lactococcus_phage	1.2e-53	94.4
WP_023164697.1\|2474022_2474817_+	hypothetical protein	Q9AZI6	Lactococcus_phage	2.1e-144	91.3
WP_080681483.1\|2476708_2476864_+	hypothetical protein	Q9AZE3	Lactococcus_phage	4.5e-19	92.2
WP_023164698.1\|2476891_2477500_+	hypothetical protein	Q9AZE2	Lactococcus_phage	3.1e-95	94.6
WP_023164699.1\|2477508_2478099_+\|head,protease	HK97 family phage prohead protease	Q9AZE1	Lactococcus_phage	7.6e-107	98.0
WP_023164700.1\|2478316_2478646_+	hypothetical protein	Q9AZE0	Lactococcus_phage	7.3e-51	94.4
WP_043994857.1\|2478748_2479069_+	sigma-70 family RNA polymerase sigma factor	Q9AZD9	Lactococcus_phage	5.1e-49	94.3
WP_003131983.1\|2479786_2479987_+	hypothetical protein	NA	NA	NA	NA
WP_003131984.1\|2480045_2481386_-	type I glutamate--ammonia ligase	A0A2P1EM84	Moumouvirus	1.8e-10	23.7
WP_003131985.1\|2481447_2481813_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_010906378.1\|2481913_2482351_-	low molecular weight phosphotyrosine protein phosphatase	NA	NA	NA	NA
WP_023164702.1\|2482763_2483381_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.9e-09	28.2

DBSCAN-SWA_15

2530162 : 2549705

Lactococcus_phage(89.47%)

head,bacteriocin,integrase,protease

attL 2530056:2530075|attR 2544966:2544985

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2530056:2530075	attL	NA	NA	NA	NA
WP_023164717.1\|2530162_2531341_-\|integrase	site-specific integrase	Q9AZK8	Lactococcus_phage	2.8e-92	47.6
WP_023164718.1\|2531787_2531952_-\|bacteriocin	bacteriocin	Q9AZK6	Lactococcus_phage	3.0e-21	96.3
WP_011834160.1\|2532920_2533247_-	hypothetical protein	NA	NA	NA	NA
WP_023164719.1\|2534203_2534398_-	hypothetical protein	Q9AZK1	Lactococcus_phage	1.1e-27	95.3
WP_023164720.1\|2534538_2535009_-	XRE family transcriptional regulator	U3PBN8	Staphylococcus_phage	1.4e-07	40.8
WP_023164721.1\|2535139_2535370_+	hypothetical protein	NA	NA	NA	NA
WP_023164722.1\|2535531_2536200_+	hypothetical protein	R9QNB1	Lactococcus_phage	2.7e-92	80.6
WP_109009810.1\|2536541_2536664_+	CopG family transcriptional regulator	NA	NA	NA	NA
WP_023164580.1\|2536850_2537072_+	hypothetical protein	NA	NA	NA	NA
WP_023164579.1\|2537086_2537284_+	DUF1655 domain-containing protein	Q9AZF2	Lactococcus_phage	5.4e-25	93.4
WP_023164723.1\|2537280_2537814_+	hypothetical protein	Q9AZJ3	Lactococcus_phage	2.0e-50	63.2
WP_023164724.1\|2537806_2538088_+	hypothetical protein	Q9AZJ1	Lactococcus_phage	2.7e-46	95.7
WP_023164575.1\|2538130_2538370_+	hypothetical protein	Q9AZJ0	Lactococcus_phage	2.6e-37	96.2
WP_023164574.1\|2538366_2538621_+	hypothetical protein	Q9AZE9	Lactococcus_phage	1.4e-36	86.7
WP_014570844.1\|2538617_2538929_+	hypothetical protein	NA	NA	NA	NA
WP_023164573.1\|2538925_2539255_+	hypothetical protein	Q9AZI7	Lactococcus_phage	1.2e-53	94.4
WP_023164572.1\|2539258_2540053_+	hypothetical protein	Q9AZI6	Lactococcus_phage	1.2e-144	91.7
WP_023164725.1\|2540063_2541692_+	DNA primase	Q9AZI5	Lactococcus_phage	2.6e-298	93.4
WP_003131978.1\|2541908_2542091_+	hypothetical protein	Q9AZE3	Lactococcus_phage	7.9e-23	93.1
WP_023164726.1\|2542116_2542725_+	hypothetical protein	Q9AZE2	Lactococcus_phage	1.6e-96	95.0
WP_023164727.1\|2542733_2543324_+\|head,protease	HK97 family phage prohead protease	Q9AZE1	Lactococcus_phage	2.3e-103	95.9
WP_023164728.1\|2543536_2543866_+	hypothetical protein	Q9AZE0	Lactococcus_phage	2.8e-50	93.6
WP_023164729.1\|2543968_2544289_+	sigma-70 family RNA polymerase sigma factor	Q9AZD9	Lactococcus_phage	3.5e-50	96.2
WP_003131244.1\|2545072_2546083_-	type I glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
2544966:2544985	attR	NA	NA	NA	NA
WP_017865257.1\|2546158_2546353_-	hypothetical protein	NA	NA	NA	NA
WP_003131246.1\|2546362_2546884_-	DUF536 domain-containing protein	NA	NA	NA	NA
WP_023164730.1\|2547011_2549705_+	cation-translocating P-type ATPase	M1HLC0	Paramecium_bursaria_Chlorella_virus	3.6e-71	27.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP029293

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_022593

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection