CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022592	Clostridium autoethanogenum DSM 10061, complete sequence	5 crisprs	DinG,PD-DExK,csa3,DEDDh,cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6,WYL,cas3HD,c2c10_CAS-V-U3	1	9	2	0

1. NC_022592

CRISPR-Cas detection and classification

Crispr_ID: NC_022592_1

• CRISPR_ID: NC_022592_1
• CRISPR_location: 646125-646321
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_022592_1

Consensus_repeat	Method
AATGAATAAGTGATTCACACCAAATCAAAGATTTGGGTTCTAATTTAGGTAACTC	PILER-CR

spacers of NC_022592_1

>1.1|646180|16|NC_022592|PILER-CR
CTTCTCCTTTCAGTCG
>1.2|646251|16|NC_022592|PILER-CR
TTTCTCCTTTCAGTCG

CRISPR arrays and Neighbor proteins around NC_022592_1

CRISPR arrays

The CRISPR arrays of NC_022592_1

>merge|NC_022592|1|646125-646321|PILER-CR
AATAAGTAAGTGATTCACACCAAATCGAAGATTTGGGTTCTAATTTGCGTAACTCCTTCTCCTTTCAGTCGAATGAATAAGTGATTCACACCAAATCAAAGATTTGGGTTCTAATTTAGGTAACTCTTTCTCCTTTCAGTCGAATGAATAAGTGATTCACACCAAATCAAAGATTTGGGTTCTAATTTAGGTAACTC

>NC_022592|1|1|646125-646321|PILER-CR
AATAAGTAAGTGATTCACACCAAATCGAAGATTTGGGTTCTAATTTGCGTAACTC	CTTCTCCTTTCAGTCG
AATGAATAAGTGATTCACACCAAATCAAAGATTTGGGTTCTAATTTAGGTAACTC	TTTCTCCTTTCAGTCG
AATGAATAAGTGATTCACACCAAATCAAAGATTTGGGTTCTAATTTAGGTAACTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022592.1|WP_013239178.1|659223_659922_-|2-hydroxycarboxylate-transporter-family-protein	unknown	unknown	gnl|CDD|377030
NC_022592.1|WP_013239177.1|658582_659098_-|citrate-lyase-holo-[acyl-carrier-protein]-synthase	unknown	unknown	gnl|CDD|377135
NC_022592.1|WP_013239162.1|640504_640957_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293792
NC_022592.1|WP_013239163.1|641138_641810_+|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224103
NC_022592.1|WP_013239176.1|658209_658506_+|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_023161884.1|648203_651410_-|carbamoyl-phosphate-synthase-(glutamine-hydrolyzing)-large-subunit	unknown	unknown	gnl|CDD|235393
NC_022592.1|WP_035787729.1|643978_645082_-|amidase-domain-containing-protein	unknown	unknown	gnl|CDD|378910
NC_022592.1|WP_013239175.1|657665_658124_-|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_013239172.1|653825_654728_-|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl|CDD|223257
NC_022592.1|WP_013239160.1|639251_639947_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
NC_022592.1|WP_023161882.1|645201_646107_-|M15-family-metallopeptidase	unknown	unknown	gnl|CDD|379247
NC_022592.1|WP_023161883.1|646836_647973_+|aldo/keto-reductase	unknown	unknown	gnl|CDD|224370
NC_022592.1|WP_013239158.1|637321_638005_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NC_022592.1|WP_013239161.1|639949_640318_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224639
NC_022592.1|WP_023161885.1|651453_652518_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl|CDD|237139
NC_022592.1|WP_013239159.1|638466_639252_-|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_023161886.1|652532_653534_-|ornithine-carbamoyltransferase	unknown	unknown	gnl|CDD|179366
NC_022592.1|WP_013239173.1|654774_655398_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
NC_022592.1|WP_023161881.1|642375_643902_+|M56-family-metallopeptidase	unknown	unknown	gnl|CDD|310280
NC_022592.1|WP_013239164.1|641989_642364_+|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl|CDD|367747

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022592.1|WP_013239177.1|658582_659098_-|citrate-lyase-holo-[acyl-carrier-protein]-synthase	gnl|CDD|377135	pfam03802, CitX, Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase.	1.61268e-81
NC_022592.1|WP_013239162.1|640504_640957_-|MBL-fold-metallo-hydrolase	gnl|CDD|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	6.31523e-08
NC_022592.1|WP_013239163.1|641138_641810_+|NAD(P)H-dependent-oxidoreductase	gnl|CDD|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	3.58608e-56
NC_022592.1|WP_023161884.1|648203_651410_-|carbamoyl-phosphate-synthase-(glutamine-hydrolyzing)-large-subunit	gnl|CDD|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NC_022592.1|WP_035787729.1|643978_645082_-|amidase-domain-containing-protein	gnl|CDD|378910	pfam12671, Amidase_6, Putative amidase domain.	1.29099e-53
NC_022592.1|WP_013239172.1|653825_654728_-|fumarylacetoacetate-hydrolase-family-protein	gnl|CDD|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	7.92704e-96
NC_022592.1|WP_013239160.1|639251_639947_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.13517e-62
NC_022592.1|WP_023161882.1|645201_646107_-|M15-family-metallopeptidase	gnl|CDD|379247	pfam13539, Peptidase_M15_4, D-alanyl-D-alanine carboxypeptidase. This family resembles VanY, pfam02557, which is part of the peptidase M15 family.	2.229e-21
NC_022592.1|WP_023161883.1|646836_647973_+|aldo/keto-reductase	gnl|CDD|224370	COG1453, COG1453, Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only].	3.2075e-163
NC_022592.1|WP_013239158.1|637321_638005_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.24904e-82
NC_022592.1|WP_013239161.1|639949_640318_-|GntR-family-transcriptional-regulator	gnl|CDD|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	3.2356e-37
NC_022592.1|WP_013239178.1|659223_659922_-|2-hydroxycarboxylate-transporter-family-protein	gnl|CDD|377030	pfam03390, 2HCT, 2-hydroxycarboxylate transporter family. The 2-hydroxycarboxylate transporter family is a family of secondary transporters found exclusively in the bacterial kingdom. They function in the metabolism of the di- and tricarboxylates malate and citrate, mostly in fermentative pathways involving decarboxylation of malate or oxaloacetate.	3.7225e-70
NC_022592.1|WP_023161885.1|651453_652518_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl|CDD|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NC_022592.1|WP_023161886.1|652532_653534_-|ornithine-carbamoyltransferase	gnl|CDD|179366	PRK02102, PRK02102, ornithine carbamoyltransferase; Validated.	0
NC_022592.1|WP_013239173.1|654774_655398_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	2.93413e-23
NC_022592.1|WP_023161881.1|642375_643902_+|M56-family-metallopeptidase	gnl|CDD|310280	pfam05569, Peptidase_M56, BlaR1 peptidase M56. Production of beta-Lactamase and penicillin-binding protein 2a (which mediate staphylococcal resistance to beta-lactam antibiotics) is regulated by a signal-transducing integral membrane protein and a transcriptional repressor. The signal transducer is a fusion protein with penicillin-binding and zinc metalloprotease domains. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. homologs to this peptidase domain, which corresponds to Merops family M56, are also found in a number of other bacterial genome sequences.	1.2168e-54
NC_022592.1|WP_013239164.1|641989_642364_+|BlaI/MecI/CopY-family-transcriptional-regulator	gnl|CDD|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	2.28386e-41

Protein sequences

>NC_022592.1|WP_023161882.1|645201_646107_-|M15-family-metallopeptidase
MKKKIIIIALLLICVCVSPVKALTDDYYTTMKQDILCLMMAYPEYITDLEKSNDGKVYVVTKSGKRILYDDKDSKNFQKKMYNTDLQDMLEQTYPIGTINGVMEKDFDPGRVRTYPLLKEVYGCDRKAIESNLKMANLGYRRFQFNGNNNAAKSLESAVKELMPISQRNPKVYKALFPSSGTFNYRCISGTSLLSPHSFGIAIDLARDRRDYWKWVTKEEGDKRIQEYPKEIVDVFEKNGFVWGGKWSHFDILHFEYRPEIILKSKYFGQKNSNNKFWYSQAPYNDKLVNGYIQKIDEKLK
>NC_022592.1|WP_035787729.1|643978_645082_-|amidase-domain-containing-protein
MAMKNSLKKRLYQVAIIILFIFLIFPFYRAKCEEADSKEEAVNSIQNIFENRNKAILNGDLKLIEGNYDKNTRYGTWAYEHEEKKMKYLKNWEEKQNVKFIQISPDIMIKRIRGKDNKYSVNLICSTEYSYIYENDPKLINKFRIGTSHILNIAKRSEGWIITKEWYKDPFADSLNLNNLKVDNVNQYIQSQNKRDFSNIGDRRKGAVEYADKYCGIASEKEYGYSYNRKYRNYNSQGGDCANFASQILHEGSKFRKTSSWNYDKTGATASWINAGGFKDYMIYSGRASLIAHGSYEKVYKASYKLLPGDFVAYEKKGDITHISVVTGADSKGYSLVSCHNTDRNRVPWDLGWSDKNIKFWLVHVNY
>NC_022592.1|WP_023161881.1|642375_643902_+|M56-family-metallopeptidase
MSTLMKSIFTASLNGSILVILILLIKNLLKERLKAEFHYILWFLLIIKLIIPYGPESNLSIFNIYNSVSEKNSTVSSKYYLKTSNTSKNKLKDSNVPVNLSKNKNIESSNKKINYKSILFFIWLIGMVFFIANTLYEIRKVQLIKKNAISNKSSNFNNILNNCLNIMNINKSVSLIYPYKSIGPCLCGLIKPTIFIPQNIIENISEDEFKHIIIHELCHLKRKDLLINWIIIILNTVYWFNPIIRYGFYKMKQDCETSCDAYAIRYLGIDRNINYGNTIIKILQLENHTPSLITSAPMAVNNSEIKRRITMISKHKKNSLKNIICGILVIAAVTTIGLTSGISKANPNSDNLNSKPYYESIMDYLINSVKGHSSLYNMNSNENNNFTSNNSLGFNGTGEFQFKELNFIGYKKYWSSNFENNIFAAEFDLFNGMESYKITSSKPTYSIKINTDIKKGSVAISIYNNKKVLFEKANPTDKTITISKEDAKNIKLQCIGVKASGNIRFELN
>NC_022592.1|WP_013239164.1|641989_642364_+|BlaI/MecI/CopY-family-transcriptional-regulator
MKETSSISDAELTIMKIIWKNPNITANKIIEQLSDKTKWKPNTVKTLINRLLKKNVIGFNKEGKEYFYYAVVQEESYINAESNSFLNKIFNGSVISMVLNFVDNKKLSKNEIKELKDILNKNRE
>NC_022592.1|WP_013239163.1|641138_641810_+|NAD(P)H-dependent-oxidoreductase
MKKLLYITANTKPEDLSVSKTVGRSFVKEFLSKNADYMVEELDLYNENIPEINHRIFKGRAELVSGNDYNTLSDEDKKIVDRINELCNQFLSADTYVIAAPMWSVSYPARLKSYLDCIIINNRLIKISEEDIKGLLDDKKRNMVYIQSSAAVYPKIFNSKFNHAIDYFRDVFKFLGVNKFDYILVEGTEDSSVGKAKAIGNVQNNIKSVVNKFTENIPLMDRM
>NC_022592.1|WP_013239162.1|640504_640957_-|MBL-fold-metallo-hydrolase
MLFKLSKTQQITGNIYVVRSLISNFFIYSDFRTTICFDTGFIPSVVNRELKKINIEPKSVSHVFLTYPSFYHAGCIKLFKNADIYFSAETSLKKSGKGMFSCKSDENEKYKKLKDGDVVDVDGIRIKSIVFPKHKLGSISYMVNDDILFI
>NC_022592.1|WP_013239161.1|639949_640318_-|GntR-family-transcriptional-regulator
MDVEFDSNVPIYMQIIDIVKRKIVKEELKPGDKLLSVREMSSKLKVNPNTIQRAYQELERNDIAYKQRGTGTFIKEDISMVEKLKEEMAQKIIYSFIIGMKELGFSSDEIIKIVEEKVQGGK
>NC_022592.1|WP_013239160.1|639251_639947_-|ABC-transporter-ATP-binding-protein
MEPLLKSTDLKKLYFRKQALDGLNLEIQKGKITGLLGPNGSGKTTFLKIAAGILRQSSGEILINGNKPGTKTKAEVSYLPDKDYLFKWMRIEDAVNFFKDMYADFDGDKAQDMLKFMNLDPDSKVKTLSKGMSEKLYLSLVLSRKAKLYILDEPLGGVDPTTREKILDAILENYTENSSVLITTHLVSDIERLFDDVAFISEGKIVLFGNAEELRNERKMSIDEIYREVFK
>NC_022592.1|WP_013239159.1|638466_639252_-|hypothetical-protein
MFKLVKYDLQGYFKDFLIMISAIVILNVALFTRVNVWNSGSILALNMAIGFAAEIIVVIWNVKLFSRDIREDTSILLFTLPKSGKNILMNKIVTALIQMVVVQFVIFIFTAMWIQIFKVVQGGVIDIKISFIQFIKNINPKFALFTFLAILVIYVTFLLTVYISITLSKVAIKNRKFGKLGSFIIFVILCIAQGKIAEIFSEAFPQTFKLKVLNLDIPSVDPNNVVANGIDINIVSIFVSVAVLIGLFYATAYLIENKLDL
>NC_022592.1|WP_013239158.1|637321_638005_-|response-regulator-transcription-factor
MNKTILMVDDEERMRFLIEAYLKSEGLNMIPAGNGQEALEKFNENHVDLVVLDIMMPVMDGWTACKELRKISNVPIIMLTARAEDEEQLLGFQLGTDSYVTKPVSPKVLVAKIKALLKRTYSEEENQNKQNSYDGLYINREGHEVKVDDENVYLSPKEFELLCYLIKNKDIVLSREKILDAIWGIDYYGDLRTVDTHVKRLREKLGVKSYLIATVRGVGYKFEVKKQ
>NC_022592.1|WP_023161883.1|646836_647973_+|aldo/keto-reductase
MQYRKFCKDGFKVSTLGFGCMRLPIINNDPSKINEKEALKIIRHAIDNGVNYLDTAYPYHGGNSEVLVGKVLKDGYREKVRIATKMPVWLVEKYEDFDKYLNEQLERLDVDYIDYYLLHAMTKDRMDKMENLGVFKFLNKALEDGKINHVGFSFHDNLMAFKHIINLFPWEFCQIQFNYLDEDYQAGIDGLEYAADKGLSVVVMEPLKGGLLSGNLPEDINNILNKSKIKKSPVDWALSWVLNHPEVSVSLSGMNSLEQVNENISIASKTLSNSISEEDMDLIEQAKEKFNALMKIKCTRCGYCSPCKVDLDIPNIFSMYNNYFMYKSKESIFNKYNNMPKKSKASSCISCGKCEDNCPQHLPIRTLLRQVKSTFEEK
>NC_022592.1|WP_023161884.1|648203_651410_-|carbamoyl-phosphate-synthase-(glutamine-hydrolyzing)-large-subunit
MPLRENLKKVLIIGSGPIIIGQAAEFDYSGTQACEAIKKEGIQTVLVNSNPATIMTDKNIADKTYIEPLTVESLEAIIGREKPDGVLAGFGGQTALNLAMELNEIGVFKKYNVELLGIKTESIKNAEDRESFKNLMNEIDEPIAVSEIATNLEECKKFLNKVSLPIIIRPAYTLGGTGGGIASTYEEYMEICENGLEESPINQILLEQSLAGWKELEYEIMRDKKDNCMVVCNMENLDPVGIHTGDSIVVAPSQTLNDREYQMLRRSAIKIIRTLKIEGGCNIQFALDPNSNRYMVIEVNPRVSRSSALASKAAGYPIAKIAAKIALGYTLDELKNYVTGNSSALFEPALDYCVVKMPKWPFDKFKTANRTLKTQMKATGEVMAIDRSFESALLKAVISLEGKIIGLKLDKLENMSKDEIIEKINNQDDERLFALAEALRKGMTIDELHELTKIDEWFLGGIENIVNMENELTSNVPNVETIQKAEIMGFTDEYICKLIGMKLEDLKKLREVNGIKSVYKMVDTCSGEFEAKTSYYYSCYDLESDNVVSNNKKILVIGSGPIRIGQGIEFDYCCVNGVWAIKKAGYEAIIINNNPETVSTDFDISDKLYFEPLYIDDVMNVINEEKVDGVIVQFGGQTALNLSKKLNDRGVNLLGTSFESIDLAEDREKFRVLLKELDINSPVGGSVTSLEEADNLVAEIGYPVIVRPSYVIGGRAMKVVYNYEELCKYLKDAVNLSKEHPVLVDKYIVGKEIEVDAISDGEDLIIPGIMEHIEKTGVHSGDSIAVYPASDLPENVLKKIEDYTVKIAKKLNVKGLLNVQYAFDGDKVYVIEVNPRASRTVPILSKVTNIPMVEIAVEVMLGKKIKDFHYKQDMYKYSNIYAVKMPIFSNKKLSGVDVALGPEMKSTGEVLGVDFDKDKAIYKAFKASGVKILQEGNLYASVNDIDKKTSLNVIKKYGELGFSISASSGTYKFLSENGVKCSELDLDTAVEYIKDKKIDVVINTATQGYNTTRQGFILRHTALAHDKIVFTCLDTANAYINAILTEKNKENIEYRTMGEYLQEPAIRS
>NC_022592.1|WP_023161885.1|651453_652518_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MNSILYLEDGTVFMGKAIGHKAITAGELVFNTSMTGYQEILTDPSYRGQIITMCYPYIGNYGINYNFSQSDDIQAKGMVIKNMYNNTSHYLSENSFENFLKENKVVGISGIDTRSITKKIRSSGTMKCVICSENESISEIKRMLNSYENKNLVSQVSTNSIKYISGNGPKVALLDFGSKKNIIENLKDRDCDITIFPYNASYESIMSINPKGILLSNGPGDPKDLGEIMGTIKKLIGNLPIFGICLGHQLLSLALGGDTYKMKFGHRGGNHGVYDKDIDKAFITSQNHGYAVKRESLNKDSIEVTHFNLNDHTVEGIKHKTLPIFSAQFHPEGSPGPTDTDYLFDKFLRLMTLV
>NC_022592.1|WP_023161886.1|652532_653534_-|ornithine-carbamoyltransferase
MIDLKGKSFLTLKDFTKEEIKYFIDLAKKLKEEKYSGTEKKRLQGKNIALIFEKDSLRTRCSFEVSAYDEGANVVYIGAQGSHMGKKESVKDTARVMGRMFHGIEYRGFSQRDMEILAEYSKVPVWNGLSDEDHPTQVLADFLTIEEHIAKPLKDVNFVYIGDGRNNMANALMIGASKVGMNFKIAAPKELFPEEELVKECKKVAEESGGTITITEDLYKAVEGADVLYTDVWLSMGEEKELWKKRIETLMPYQINSKLIEACKNENVKFMHCLPAFHNTETKVGEEIYKKFGYEALEVTEEVFEGPHSIVFDEAENRLHTIKAVMVATLSNI
>NC_022592.1|WP_013239172.1|653825_654728_-|fumarylacetoacetate-hydrolase-family-protein
MKFLTYLYKEKESIGILKNNSVIDFDNIFKNMGEKNPPKTMLELIDYLDDSKLNIIKECIDKKGIETIPINNIKIEAPIPYPRRNVFCLGKNYIEHAREIKITRIAGNGIPEVPIYFTKAASPAVGTVDNIEFSRKITNQVDYEVELAVIIGKDGKNIKKEDAEEYIFGYTIINDVSARDLQGKHIQWFKGKSLDTFCPMGPYIIHKTEVPFPVNLDISCTVNGEVRQKSNTKNLIFDIPYIISDLSKGITLKTGDIISTGTPSGVGMGFTPIKVLKQGDIVECSIEKIGTLVNRVVELH
>NC_022592.1|WP_013239173.1|654774_655398_-|class-I-SAM-dependent-methyltransferase
MSELSRRLNQCRKPTGEVGKFIASSMNKDHFEVTTWGLNKISIKQEDIILDIGCGGGRTINRLANIAKKGKVIGVDYSMDCVNWSKEFNKELIDEKRVEVYNANVEKLPFEDDKFNVVTAVETIYFWPDLLKSFKEVKRVLKSNGIFTVINEMYISDKFKEKNDEYMDKMTMHTPEQLKQLFVDAGYEDVSINVCEENNWMCCSGRA
>NC_022592.1|WP_013239175.1|657665_658124_-|hypothetical-protein
MNENENMLHKFIKNYTENKQNRVQDLGTKKEKLEIQLKKEEEKLDKLSAIKEKLIAKEKSYDEVYSYLLQILKSRGILFDIPKSAVEIEEWDNLYIKKEQGAYSLIDKNQQVVYSIDKKYYDSIEHIVTNYKYSAVVVRKDAYFLKVQIRIL
>NC_022592.1|WP_013239176.1|658209_658506_+|hypothetical-protein
MDKVYTLILKYIKKIKKSIIFGMQNLNLFFDKKKTIDTAYKPMLDEKLKEVKDLKDKLNVMQNNNASFEKQIKHLRGSMMKKEKLIKNLQDIISQRQN
>NC_022592.1|WP_013239177.1|658582_659098_-|citrate-lyase-holo-[acyl-carrier-protein]-synthase
MKNASNILDEILKAKEKRAQIQKELLNIFKTTLISFTLNIPGAEKNNESFAKLHKKGICLLEEELKENNIDILHKMLNSSAAGDEAFLNVDADAISVKKITVSIEENHELGRIFDFDVFTKAGKQISRTDLGVSERKCLLCGENAKVCGRSRRHSVEDLLNKIYLLMDKFL
>NC_022592.1|WP_013239178.1|659223_659922_-|2-hydroxycarboxylate-transporter-family-protein
MLKVMLLGWLSTAISIAYTIINIGEVRPELSGNGQLLKSDDDDILKYAKKKKDGPVELSTMIVAGILALTLYLFGVYINSVIGLPAPIVMLLAAVISKALGIIPKSIEEGGHAIFRFTVTGITVPLLLGVGVAMTPWKNLVAVITNPACLVTIFCTVLTVVVVEFFVGKMLNMNPVESAMVTSCNSGQGGTGDVAILTAGNRLELMPFAQVATRLGGAATVTWAIFLMRMLH

Crispr_ID: NC_022592_2

• CRISPR_ID: NC_022592_2
• CRISPR_location: 1245643-1245734
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_022592_2

Consensus_repeat	Method
ACCAATGATTGCTATAATAAATA	CRISPRCasFinder

spacers of NC_022592_2

>2.1|1245666|46|NC_022592|CRISPRCasFinder
TAGCCACCGCAGTTGCCTGTCCTGCTACATAAGCATTTGTAACAAA

CRISPR arrays and Neighbor proteins around NC_022592_2

CRISPR arrays

The CRISPR arrays of NC_022592_2

>merge|NC_022592|2|1245643-1245734|CRISPRCasFinder
ACCAATGATTGCTATAATAAATATAGCCACCGCAGTTGCCTGTCCTGCTACATAAGCATTTGTAACAAAACCAATGATTGCTATAATTAATA

>NC_022592|2|1|1245643-1245734|CRISPRCasFinder
ACCAATGATTGCTATAATAAATA	TAGCCACCGCAGTTGCCTGTCCTGCTACATAAGCATTTGTAACAAA
ACCAATGATTGCTATAATTAATA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022592.1|WP_081442083.1|1246728_1247031_+|DnaD-domain-protein	unknown	unknown	gnl|CDD|377797
NC_022592.1|WP_158212036.1|1249449_1249602_+|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_023162158.1|1240085_1241306_+|multidrug-efflux-MFS-transporter	unknown	unknown	gnl|CDD|340949
NC_022592.1|WP_013239864.1|1248543_1249314_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|128898
NC_022592.1|WP_013239867.1|1250602_1250827_+|DUF1659-domain-containing-protein	unknown	unknown	gnl|CDD|377933
NC_022592.1|WP_013239862.1|1247549_1247990_+|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_013239870.1|1252133_1253033_+|EamA-family-transporter	unknown	unknown	gnl|CDD|273359
NC_022592.1|WP_013239852.1|1239280_1239892_-|DUF975-family-protein	unknown	unknown	gnl|CDD|283754
NC_022592.1|WP_013239851.1|1238469_1239225_+|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_013239850.1|1237849_1238077_-|DUF3892-domain-containing-protein	unknown	unknown	gnl|CDD|379026
NC_022592.1|WP_013239856.1|1242739_1243156_+|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl|CDD|226389
NC_022592.1|WP_013239855.1|1242294_1242651_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224647
NC_022592.1|WP_013239863.1|1248074_1248503_+|N-acetyltransferase	unknown	unknown	gnl|CDD|236715
NC_022592.1|WP_023162162.1|1251134_1251434_-|DUF3267-domain-containing-protein	unknown	unknown	gnl|CDD|378690
NC_022592.1|WP_013239849.1|1236748_1237729_+|lactate-dehydrogenase	unknown	unknown	gnl|CDD|240661
NC_022592.1|WP_013239854.1|1241351_1241912_-|phosphatase-PAP2-family-protein	unknown	unknown	gnl|CDD|239489
NC_022592.1|WP_013239858.1|1244012_1244309_+|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_023162161.1|1250354_1250519_+|YvrJ-family-protein	unknown	unknown	gnl|CDD|378969
NC_022592.1|WP_023162159.1|1244525_1244696_+|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_013239865.1|1249805_1250138_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022592.1|WP_081442083.1|1246728_1247031_+|DnaD-domain-protein	gnl|CDD|377797	pfam07261, DnaB_2, Replication initiation and membrane attachment. This family consists of several bacterial replication initiation and membrane attachment (DnaB) proteins, as well as DnaD which is a component of the PriA primosome. The PriA primosome functions to recruit the replication fork helicase onto the DNA. The DnaB protein is essential for both replication initiation and membrane attachment of the origin region of the chromosome and plasmid pUB110 in Bacillus subtilis. It is known that there are two different classes (DnaBI and DnaBII) in the DnaB mutants; DnaBI is essential for both chromosome and pUB110 replication, whereas DnaBII is necessary only for chromosome replication. DnaD has been merged into this family. This family also includes Ftn6, a cyanobacterial-specific divisome component possibly playing a role at the interface between DNA replication and cell division. Ftn6 possesses a conserved domain localized within the N-terminus of the proteins. This domain, named FND, exhibits sequence and structure similarities with the DnaD-like domains pfam04271 now merged into pfam07261.	5.97559e-13
NC_022592.1|WP_023162158.1|1240085_1241306_+|multidrug-efflux-MFS-transporter	gnl|CDD|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.35707e-166
NC_022592.1|WP_013239864.1|1248543_1249314_+|methyltransferase-domain-containing-protein	gnl|CDD|128898	smart00650, rADc, Ribosomal RNA adenine dimethylases.	1.82174e-11
NC_022592.1|WP_013239867.1|1250602_1250827_+|DUF1659-domain-containing-protein	gnl|CDD|377933	pfam07872, DUF1659, Protein of unknown function (DUF1659). This family consists of hypothetical bacterial proteins of unknown function.	1.64228e-10
NC_022592.1|WP_013239852.1|1239280_1239892_-|DUF975-family-protein	gnl|CDD|283754	pfam06161, DUF975, Protein of unknown function (DUF975). Family of uncharacterized bacterial proteins.	1.29698e-36
NC_022592.1|WP_013239850.1|1237849_1238077_-|DUF3892-domain-containing-protein	gnl|CDD|379026	pfam13031, DUF3892, Protein of unknown function (DUF3892). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 87 and 104 amino acids in length.	5.76692e-15
NC_022592.1|WP_013239856.1|1242739_1243156_+|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl|CDD|226389	COG3871, COG3871, Uncharacterized stress protein (general stress protein 26) [General function prediction only].	8.83049e-29
NC_022592.1|WP_013239855.1|1242294_1242651_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	9.91799e-26
NC_022592.1|WP_013239863.1|1248074_1248503_+|N-acetyltransferase	gnl|CDD|236715	PRK10562, PRK10562, putative acetyltransferase; Provisional.	8.635e-41
NC_022592.1|WP_013239849.1|1236748_1237729_+|lactate-dehydrogenase	gnl|CDD|240661	cd12185, HGDH_LDH_like, Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains. This group contains various putative dehydrogenases related to D-lactate dehydrogenase (LDH), (R)-2-hydroxyglutarate dehydrogenase (HGDH), and related enzymes, members of the 2-hydroxyacid dehydrogenases family. LDH catalyzes the interconversion of pyruvate and lactate, and HGDH catalyzes the NAD-dependent reduction of 2-oxoglutarate to (R)-2-hydroxyglutarate. Despite often low sequence identity within this 2-hydroxyacid dehydrogenase family, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain.	0
NC_022592.1|WP_013239854.1|1241351_1241912_-|phosphatase-PAP2-family-protein	gnl|CDD|239489	cd03395, PAP2_like_4, PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	7.23932e-28
NC_022592.1|WP_013239870.1|1252133_1253033_+|EamA-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.20237e-18
NC_022592.1|WP_023162162.1|1251134_1251434_-|DUF3267-domain-containing-protein	gnl|CDD|378690	pfam11667, DUF3267, Putative zincin peptidase. This family of proteins has a conserved HEXXH motif, suggesting the members are putative peptidases of zincin fold.	0.00359774
NC_022592.1|WP_023162161.1|1250354_1250519_+|YvrJ-family-protein	gnl|CDD|378969	pfam12841, YvrJ, YvrJ protein family. This family of short proteins are related to B. subtilis YvrJ protein. None of the members of this family have been functionally characterized.	4.59812e-12

Protein sequences

>NC_022592.1|WP_023162159.1|1244525_1244696_+|hypothetical-protein
MHVCVNKYRESPDTPFPGSGHLKPEDEKLRRLTKELVINALNDAYQRGGRPKFHIY
>NC_022592.1|WP_013239858.1|1244012_1244309_+|hypothetical-protein
MVEMTNSKKWGIGSLSLIIAIFSIMFSFTFINGKYIGEHILNGLGVSFPIGIISLALFCASILIGHKYKNDYLAKSGKIVSIIFILLIIILSIISSLF
>NC_022592.1|WP_013239856.1|1242739_1243156_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MKNPEKTIGNLIDKSNVTIISYIDNGGFPISKAMLSPREREGIKTFWFSTNTSSNKVRYFRKNPKASVYFVNKRFFRGVSLVGIVEVLETLEAKERLWQDGDTIYYKQGATDPDYCVLKFTAKKGRYYSNFKSEDFDI
>NC_022592.1|WP_013239855.1|1242294_1242651_+|helix-turn-helix-transcriptional-regulator
MKLRNEYTCPLELTHDIIRGKWKPIILWQLGKGASSLAYLQEDIKGIGQKMLLQHLSELQDFGMVQKKQFSGYPLKVEYSLTEKGKRMLDVVVTMQKIGIELMKEDGKEAFLKEKGLI
>NC_022592.1|WP_013239854.1|1241351_1241912_-|phosphatase-PAP2-family-protein
MVTLIYKFDEYILSYIANNMHNQILDKVMIAFTSLGNKGLIWIAISIVLIASKKYRKVGIMVLTAIIIGSILGEGLIKHIVKRTRPFYFDPTIKLLVAKPASYSFPSGHTTASFAAASILSRYFKKYAPVIFTVAILIAFSRIYLYVHYPTDVLAGIVLGLVSSKITIYLFKRIKSYLLKKLKSSI
>NC_022592.1|WP_023162158.1|1240085_1241306_+|multidrug-efflux-MFS-transporter
MKIWKRNLIVCWLGAFVTALGLSQIAPIMPLYIKQLGIHDISTIEQISGVAFGVTFVVLAIFSPIWGYAADKIGRKPMLLRASIGMSIVISTMGLAQNIYQLIGLRMLQGVVAGYSTACMTLIATQTEKEHSGWALGVLSTASISGSLLGPLIGGYLDEILGLQFTFFFTGILMLIVFILTLIFVKENFIKSNKKVLSTKEVWKQLPDCHLTIVLFATSFILQLAFYSIEPIITVYISQLSRSSAHIALISGMAFSASGLASIIAAPRLGKLSDKIGPQKVMLASLIIAGLIFIPQAFVKNSWQLIILRFSLGFVTAGLAPSINTLVKKITPEALTGRMFGFNMSAFYLGTFSGSLLGGQIASYFGMKYVFFITSALLLLNGLLVYEKICKKLDSNAAAPLKEHMV
>NC_022592.1|WP_013239852.1|1239280_1239892_-|DUF975-family-protein
MSNASVRTSYQLRKVSRDQLKGNWGKCVLVCLVYSLIIIGINFIPHAGIIISFLIVGPLTLGVVGCFIKLVKSEKFQVEDLFDGFKNLGSAIILYIIMSIFIFLWSLLLIIPGLIASLRYSMAMYVLSENPDIPVLEALDESKKMMYGHKWELFCLLISFLGWIILSVVTFGIGFIFVCPYMQAATANFYQDVKLVPILNNQE
>NC_022592.1|WP_013239851.1|1238469_1239225_+|hypothetical-protein
MKKNIIKSSIVFMVIFALFFIASDKSTVHALNCYTVSLSNFKEVSQNIYVQPNTSDKDINNILSTISKSKNIVANLYGSFNAKPVFIISKDSTALKKFGVENKTGATQKTILGSYIVLGPEGLNTNVISHELTHSELAYRIHKSKSTKIPVWFDEGMAMQVDNRPKYSEGQWIKETQNGTKIPDMKTLNSYTQFYAADLDTRVLNYTLAKHEVHRWLSIVGQKGLSQLIDDVNNGNDFYKSYNTIEKENSK
>NC_022592.1|WP_013239850.1|1237849_1238077_-|DUF3892-domain-containing-protein
MKNSKIIKVRKDHEGKITDVLLENGEVLPLNHAIMMAREHIIEGVGVFKGKDGGEYLVADPDVMDVENLKDLPRF
>NC_022592.1|WP_013239849.1|1236748_1237729_+|lactate-dehydrogenase
MKVLAYSHRQDETEYFKKFSKKYDVEVVLCDDPPTMENADLAKGFDCISIITTKISDKLVEKFHEIGVKFISTRTIGYDHIDIKKAKELGVHIGNVNYSPNSVADYTIMMILMAIRKTKAIIERSNVQDYSLKGVQGKELHNLTVGVIGTGRIGRAVISRLSGFGCKILAYDLYENEEIKKYVTYVTLEDLFKNSDIITMHAPATDDNYHMINKDSIALMKDGTFIINIARGSLINTEDLIDAIENKKIGGAAIDVIENEFGLCYNDLKCEILDKREMAILKSFPNVIVTPHTAFYTDQAVSDMVEHSILSCVLFMEGKENPWQIE
>NC_022592.1|WP_081442083.1|1246728_1247031_+|DnaD-domain-protein
MLAFFEENIYPVGEAVREKIRMWSGVIDCDVIILAVEEALKYNVRNINYVDRILQSWSKKGLKTANDVKRYKSIWESRNTEHREKYRQYDFKELERKLFG
>NC_022592.1|WP_013239862.1|1247549_1247990_+|hypothetical-protein
MESVSELIERLYSKDNKAAYQALQILESESEKSNAVYKFFDRFAEMIENSNSYIRTRGIVLISVNAKWDTENKVDEIIDDYLKHILDEKPITARQCIKSLPSIAKYKSDLVECIREALLKVDVTIYGDSMQTLIYKDISSSLKKIK
>NC_022592.1|WP_013239863.1|1248074_1248503_+|N-acetyltransferase
MIRDFRTTDIDRVMHLWLSTNILAHNFIDSEYWQNNFESVKEMMPKASIYVYEQNGEIQAFIGLMKSFIAGIFVSSDFQSKGIGKLLLDYSKGKHNELSLCVYKKNDRALRFYLKEGFTASAEQVDENTGEIEFVMRWKNSV
>NC_022592.1|WP_013239864.1|1248543_1249314_+|methyltransferase-domain-containing-protein
MDLRLKFNEDEYNYDKYRPTYPEELFSDIINYSRISSGYEALEIGIGTGQATLPILQSGCRVTAIELGNNLTRYVKNKFKNYMNFNVINADFIEYTIKTEAFNLVYCATAFHWIPLEQGYVKVRNILKDDGTIALFWNHPFPNRQDDISNIVNRKIYNKYRPSDKEVREFNESDCQRRINELERFGFKDIIYRLYHRKRTLTSNGYIHLLNTYSDHRVLPVEVKNNFEMDMKNAIDEIGGKINIYDTIDLYLAKKK
>NC_022592.1|WP_158212036.1|1249449_1249602_+|hypothetical-protein
MLQELVGAVSFGYPDNKPNSRPRETPNRTIMILRTISLLLDQSILVLKIH
>NC_022592.1|WP_013239865.1|1249805_1250138_+|sigma-70-family-RNA-polymerase-sigma-factor
MFNHSSYLNENSINNSEDIQKKLVDIVKNVKRVNLSLMEDIILELCEVKPIKLSELVKLLNRNDVGLRSNYLNKMEGRTLKETAEILNIKYRHAIEIKKSALNKLKKYLK
>NC_022592.1|WP_023162161.1|1250354_1250519_+|YvrJ-family-protein
MYDQLVSLISTIGFPIAVSIYLLIRFENKIDLLVKSIEDLREDISAVIKNQEKK
>NC_022592.1|WP_013239867.1|1250602_1250827_+|DUF1659-domain-containing-protein
MAAKSIKLSSTLSIVEKTGLNKQGKEILKKVTLGKIAMDAADQDVYDVVKTVGDILTYPVNEIQKVDNTVITNA
>NC_022592.1|WP_023162162.1|1251134_1251434_-|DUF3267-domain-containing-protein
MSEFIIILSIINSVIHEILHGLAYKLFGVKIRFEFKLPYAYTMETSGLPIDIFKFTIILLLPLLLISLTCLFLPTWLGEIFFIINLLGSAGYIHVTVSS
>NC_022592.1|WP_013239870.1|1252133_1253033_+|EamA-family-transporter
MKLKIYFILSMMIFGTIGIFVRYIDLASSEIALLRGFIGSLFLLTITIVNKQKISWTNIKNNIPVLLLSSFALGFNWIFLFQAYKHTTIANASSSYYFAPVFVIVMSPIVLKEKISLKKAACISISVFGMFLIVQNRGNGGTEYNHLLGICYGITAAVFYATLMLTNKFIKNMNGLEITLLQLSLATVMLIPYVFVTERVNLFQITGLSVACIIILGIIHTGLGFYLFFYGMKGLRGQSIAALSYIDPITSLFTSFIIFGENMTVFQIIGAVLLLGSTFISEISKNYDCSSKKNKGYIE

Crispr_ID: NC_022592_3

• CRISPR_ID: NC_022592_3
• CRISPR_location: 1489314-1490732
• CRISPR_type: TypeI-B
• Repeat_type: II-B
• Spacer_info: 21 spacers
• Cas_protein_info: cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

Consensus repeat of NC_022592_3

Consensus_repeat	Method
ATTTAAATACATCTCATGTTGAGGTTCAAC	PILER-CR
ATTTAAATACATCTCATGTTGAGGTTCAAC	CRISPRCasFinder
ATTTAAATACATCTCATGTTGAGGTTCAAC	CRT

spacers of NC_022592_3

>3.1|1489344|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
AGGAACAACTGGGTGGAGTGCTGATGCTGTAGATAA
>3.2|1489410|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
GCTATCAAGAATTTGTTCTTCAAGCTTTTTAATTTC
>3.3|1489476|37|NC_022592|PILER-CR,CRISPRCasFinder,CRT
TTTCTTCTGCTGCTTGTACATCCCTGCGCATTGAATT
>3.4|1489543|37|NC_022592|PILER-CR,CRISPRCasFinder,CRT
TAATGGAAGATGTAAATGAAGAATTAAGTATTCAAAC
>3.5|1489610|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
CTAACAGAAAATAAAGCCGGATTTTAAAGGAGGGAC
>3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT
AATTAAATCTTCTATTTCTTTATCTGTATTGTTTA
>3.7|1489741|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
TTAACATAGTACCTGATGCGTATTATTTTGCAAACT
>3.8|1489807|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
CACAATGTGCAAACGGAGGAATTGTTTCTTCTGATA
>3.9|1489873|37|NC_022592|PILER-CR,CRISPRCasFinder,CRT
TTAAAACCCTCGGTATATTGTGCATCGCCTAAAGCTA
>3.10|1489940|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
ACCCAATAAAATATACGTTGGTATACCTGTAGACAT
>3.11|1490006|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
AGAAAAAGCCTGAACATATACGTATTATATTTAAAG
>3.12|1490072|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
GGAATTAAAAAGTTATAAGATAGACGACATATCATA
>3.13|1490138|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
TTAGTTATTCCAGTTCCGAGATTGGTATCTGTATTC
>3.14|1490204|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
GTAATTCTCTACATATTCAAGCCCGGCGTTTATATC
>3.15|1490270|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
TTATATGGCAAGTCTTTTGGTGTACTTGGATCTGCA
>3.16|1490336|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
GCATCAACTTCAGGTATAATTTGAAGCTTTTGAAAT
>3.17|1490402|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
CCAAATGCCTTTCAGGAACAGGCATAACCTTAATTT
>3.18|1490468|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT
ACAACCACTACAAAGAATACTCCTACAAAAGAAAC
>3.19|1490533|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
GGCCATTAGTGCATTAGGCGTTGACGAGTTTTGGCA
>3.20|1490599|36|NC_022592|PILER-CR,CRISPRCasFinder,CRT
AAGTATATTTAAACAAATTATAGAAGGATGGAGCAA
>3.21|1490665|38|NC_022592|PILER-CR,CRISPRCasFinder,CRT
GGGAAGCTTTATATTTAAATTTAAGTCTTTAGCAGGAA

CRISPR arrays and Neighbor proteins around NC_022592_3

CRISPR arrays

The CRISPR arrays of NC_022592_3

>merge|NC_022592|3|1489314-1490732|PILER-CR,CRISPRCasFinder,CRT
ATTTAAATACATCTCATGTTGAGGTTCAACAGGAACAACTGGGTGGAGTGCTGATGCTGTAGATAAATTTAAATACATCTCATGTTGAGGTTCAACGCTATCAAGAATTTGTTCTTCAAGCTTTTTAATTTCATTTAAATACATCTCATGTTGAGGTTCAACTTTCTTCTGCTGCTTGTACATCCCTGCGCATTGAATTATTTAAATACATCTCATGTTGAGGTTCAACTAATGGAAGATGTAAATGAAGAATTAAGTATTCAAACATTTAAATACATCTCATGTTGAGGTTCAACCTAACAGAAAATAAAGCCGGATTTTAAAGGAGGGACATTTAAATACATCTCATGTTGAGGTTCAACAATTAAATCTTCTATTTCTTTATCTGTATTGTTTAATTTAAATACATCTCATGTTGAGGTTCAACTTAACATAGTACCTGATGCGTATTATTTTGCAAACTATTTAAATACATCTCATGTTGAGGTTCAACCACAATGTGCAAACGGAGGAATTGTTTCTTCTGATAATTTAAATACATCTCATGTTGAGGTTCAACTTAAAACCCTCGGTATATTGTGCATCGCCTAAAGCTAATTTAAATACATCTCATGTTGAGGTTCAACACCCAATAAAATATACGTTGGTATACCTGTAGACATATTTAAATACATCTCATGTTGAGGTTCAACAGAAAAAGCCTGAACATATACGTATTATATTTAAAGATTTAAATACATCTCATGTTGAGGTTCAACGGAATTAAAAAGTTATAAGATAGACGACATATCATAATTTAAATACATCTCATGTTGAGGTTCAACTTAGTTATTCCAGTTCCGAGATTGGTATCTGTATTCATTTAAATACATCTCATGTTGAGGTTCAACGTAATTCTCTACATATTCAAGCCCGGCGTTTATATCATTTAAATACATCTCATGTTGAGGTTCAACTTATATGGCAAGTCTTTTGGTGTACTTGGATCTGCAATTTAAATACATCTCATGTTGAGGTTCAACGCATCAACTTCAGGTATAATTTGAAGCTTTTGAAATATTTAAATACATCTCATGTTGAGGTTCAACCCAAATGCCTTTCAGGAACAGGCATAACCTTAATTTATTTAAATACATCTCATGTTGAGGTTCAACACAACCACTACAAAGAATACTCCTACAAAAGAAACATTTAAATACATCTCATGTTGAGGTTCAACGGCCATTAGTGCATTAGGCGTTGACGAGTTTTGGCAATTTAAATACATCTCATGTTGAGGTTCAACAAGTATATTTAAACAAATTATAGAAGGATGGAGCAAATTTAAATACATCTCATGTTGAGGTTCAACGGGAAGCTTTATATTTAAATTTAAGTCTTTAGCAGGAAATTTAAATACATCTCATGTTGAGGTTCAAC

>NC_022592|3|2|1489314-1490732|PILER-CR
ATTTAAATACATCTCATGTTGAGGTTCAAC	AGGAACAACTGGGTGGAGTGCTGATGCTGTAGATAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCTATCAAGAATTTGTTCTTCAAGCTTTTTAATTTC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTCTTCTGCTGCTTGTACATCCCTGCGCATTGAATT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TAATGGAAGATGTAAATGAAGAATTAAGTATTCAAAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	CTAACAGAAAATAAAGCCGGATTTTAAAGGAGGGAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	AATTAAATCTTCTATTTCTTTATCTGTATTGTTTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAACATAGTACCTGATGCGTATTATTTTGCAAACT
ATTTAAATACATCTCATGTTGAGGTTCAAC	CACAATGTGCAAACGGAGGAATTGTTTCTTCTGATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAAAACCCTCGGTATATTGTGCATCGCCTAAAGCTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	ACCCAATAAAATATACGTTGGTATACCTGTAGACAT
ATTTAAATACATCTCATGTTGAGGTTCAAC	AGAAAAAGCCTGAACATATACGTATTATATTTAAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGAATTAAAAAGTTATAAGATAGACGACATATCATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAGTTATTCCAGTTCCGAGATTGGTATCTGTATTC
ATTTAAATACATCTCATGTTGAGGTTCAAC	GTAATTCTCTACATATTCAAGCCCGGCGTTTATATC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTATATGGCAAGTCTTTTGGTGTACTTGGATCTGCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCATCAACTTCAGGTATAATTTGAAGCTTTTGAAAT
ATTTAAATACATCTCATGTTGAGGTTCAAC	CCAAATGCCTTTCAGGAACAGGCATAACCTTAATTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	ACAACCACTACAAAGAATACTCCTACAAAAGAAAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGCCATTAGTGCATTAGGCGTTGACGAGTTTTGGCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAGTATATTTAAACAAATTATAGAAGGATGGAGCAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGGAAGCTTTATATTTAAATTTAAGTCTTTAGCAGGAA
ATTTAAATACATCTCATGTTGAGGTTCAAC

>NC_022592|3|2|1489314-1490732|CRISPRCasFinder
ATTTAAATACATCTCATGTTGAGGTTCAAC	AGGAACAACTGGGTGGAGTGCTGATGCTGTAGATAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCTATCAAGAATTTGTTCTTCAAGCTTTTTAATTTC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTCTTCTGCTGCTTGTACATCCCTGCGCATTGAATT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TAATGGAAGATGTAAATGAAGAATTAAGTATTCAAAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	CTAACAGAAAATAAAGCCGGATTTTAAAGGAGGGAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	AATTAAATCTTCTATTTCTTTATCTGTATTGTTTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAACATAGTACCTGATGCGTATTATTTTGCAAACT
ATTTAAATACATCTCATGTTGAGGTTCAAC	CACAATGTGCAAACGGAGGAATTGTTTCTTCTGATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAAAACCCTCGGTATATTGTGCATCGCCTAAAGCTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	ACCCAATAAAATATACGTTGGTATACCTGTAGACAT
ATTTAAATACATCTCATGTTGAGGTTCAAC	AGAAAAAGCCTGAACATATACGTATTATATTTAAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGAATTAAAAAGTTATAAGATAGACGACATATCATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAGTTATTCCAGTTCCGAGATTGGTATCTGTATTC
ATTTAAATACATCTCATGTTGAGGTTCAAC	GTAATTCTCTACATATTCAAGCCCGGCGTTTATATC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTATATGGCAAGTCTTTTGGTGTACTTGGATCTGCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCATCAACTTCAGGTATAATTTGAAGCTTTTGAAAT
ATTTAAATACATCTCATGTTGAGGTTCAAC	CCAAATGCCTTTCAGGAACAGGCATAACCTTAATTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	ACAACCACTACAAAGAATACTCCTACAAAAGAAAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGCCATTAGTGCATTAGGCGTTGACGAGTTTTGGCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAGTATATTTAAACAAATTATAGAAGGATGGAGCAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGGAAGCTTTATATTTAAATTTAAGTCTTTAGCAGGAA
ATTTAAATACATCTCATGTTGAGGTTCAAC

>NC_022592|3|1|1489314-1490732|CRT
ATTTAAATACATCTCATGTTGAGGTTCAAC	AGGAACAACTGGGTGGAGTGCTGATGCTGTAGATAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCTATCAAGAATTTGTTCTTCAAGCTTTTTAATTTC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTCTTCTGCTGCTTGTACATCCCTGCGCATTGAATT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TAATGGAAGATGTAAATGAAGAATTAAGTATTCAAAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	CTAACAGAAAATAAAGCCGGATTTTAAAGGAGGGAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	AATTAAATCTTCTATTTCTTTATCTGTATTGTTTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAACATAGTACCTGATGCGTATTATTTTGCAAACT
ATTTAAATACATCTCATGTTGAGGTTCAAC	CACAATGTGCAAACGGAGGAATTGTTTCTTCTGATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAAAACCCTCGGTATATTGTGCATCGCCTAAAGCTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	ACCCAATAAAATATACGTTGGTATACCTGTAGACAT
ATTTAAATACATCTCATGTTGAGGTTCAAC	AGAAAAAGCCTGAACATATACGTATTATATTTAAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGAATTAAAAAGTTATAAGATAGACGACATATCATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAGTTATTCCAGTTCCGAGATTGGTATCTGTATTC
ATTTAAATACATCTCATGTTGAGGTTCAAC	GTAATTCTCTACATATTCAAGCCCGGCGTTTATATC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTATATGGCAAGTCTTTTGGTGTACTTGGATCTGCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCATCAACTTCAGGTATAATTTGAAGCTTTTGAAAT
ATTTAAATACATCTCATGTTGAGGTTCAAC	CCAAATGCCTTTCAGGAACAGGCATAACCTTAATTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	ACAACCACTACAAAGAATACTCCTACAAAAGAAAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGCCATTAGTGCATTAGGCGTTGACGAGTTTTGGCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAGTATATTTAAACAAATTATAGAAGGATGGAGCAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGGAAGCTTTATATTTAAATTTAAGTCTTTAGCAGGAA
ATTTAAATACATCTCATGTTGAGGTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_022592.1|WP_023162220.1|1487419_1488226_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293799
NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_022592.1|WP_013240116.1|1485207_1485837_-|YhbD-family-protein	unknown	unknown	gnl|CDD|379048
NC_022592.1|WP_023162217.1|1483621_1484215_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|350688
NC_022592.1|WP_023162219.1|1486525_1487278_-|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl|CDD|187594
NC_022592.1|WP_158212035.1|1488450_1488678_-|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_023162232.1|1503835_1504351_-|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_022592.1|WP_023162231.1|1503044_1503806_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_022592.1|WP_023162216.1|1482437_1483049_-|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl|CDD|223632
NC_022592.1|WP_013240115.1|1484459_1485188_-|polymer-forming-cytoskeletal-protein	unknown	unknown	gnl|CDD|224578
NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl|CDD|131641
NC_022592.1|WP_013240111.1|1480968_1481961_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380532
NC_022592.1|WP_023162218.1|1486116_1486491_-|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_022592.1|WP_013240113.1|1483054_1483597_-|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl|CDD|180484
NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl|CDD|188234

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	7.7e-45	147.7	9.7
NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	5.4e-30	99.5	0.3
NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein	cas6	cd09652_cas6_CAS-I:CAS-III	6.8e-12	40.9	3.1
NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	2e-175	579.7	63.4
NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	4.7e-125	411.7	10.9
NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	1.4e-37	124.2	7.8
NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-50	166.6	5.5
NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.1e-24	81.2	0.7

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.24266e-48
NC_022592.1|WP_023162220.1|1487419_1488226_-|MBL-fold-metallo-hydrolase	gnl|CDD|293799	cd07713, DHPS-like_MBL-fold, Methanocaldococcus jannaschii dihydropteroate synthase, Thermoanaerobacter tengcongensis Tflp, and related proteins; MBL-fold metallo hydrolase domain. This subgroup includes Methanocaldococcus jannaschii 7,8-dihydropterin-6-methyl-4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate synthase (EC 2.5.1.15), a folate biosynthetic enzyme also known as dihydropteroate synthase and 7,8 dihydropteroate synthase. Thermoanaerobacter tengcongensis Tflp is a ferredoxin-like member. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	6.69226e-101
NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.06183e-148
NC_022592.1|WP_013240116.1|1485207_1485837_-|YhbD-family-protein	gnl|CDD|379048	pfam13171, DUF4004, Protein of unknown function (DUF4004). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 210 amino acids in length.	6.91161e-106
NC_022592.1|WP_023162217.1|1483621_1484215_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.22081e-12
NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	2.30789e-29
NC_022592.1|WP_023162219.1|1486525_1487278_-|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl|CDD|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.72485e-119
NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.87503e-50
NC_022592.1|WP_023162231.1|1503044_1503806_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.0633e-13
NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	4.92532e-07
NC_022592.1|WP_023162216.1|1482437_1483049_-|CDP-alcohol-phosphatidyltransferase-family-protein	gnl|CDD|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	4.1584e-12
NC_022592.1|WP_013240115.1|1484459_1485188_-|polymer-forming-cytoskeletal-protein	gnl|CDD|224578	COG1664, CcmA, Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane].	4.87363e-08
NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5	gnl|CDD|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.18725e-44
NC_022592.1|WP_013240111.1|1480968_1481961_-|ABC-transporter-substrate-binding-protein	gnl|CDD|380532	cd06309, PBP1_galactofuranose_YtfQ-like, periplasmic binding domain of ABC-type galactofuranose YtfQ-like transport systems. Periplasmic binding domain of ABC-type YtfQ-like transport systems. The YtfQ protein from Escherichia coli is up-regulated under glucose-limited conditions and shares homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily. Members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes; however their ligand specificity is not determined experimentally.	1.33218e-121
NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.26285e-22
NC_022592.1|WP_013240113.1|1483054_1483597_-|NAD(P)H-dependent-oxidoreductase	gnl|CDD|180484	PRK06242, PRK06242, flavodoxin; Provisional.	3.84027e-09
NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein	gnl|CDD|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	9.63104e-18

Protein sequences

>NC_022592.1|WP_158212035.1|1488450_1488678_-|hypothetical-protein
MCDGGASNGSDRIKKQQMYYHKNSYLKFRIILTANISIYRENNAAEKPGERKVAAEICYFTETLKSTANTEREHL
>NC_022592.1|WP_023162220.1|1487419_1488226_-|MBL-fold-metallo-hydrolase
MKLKVLVDNNTYIDRYYFGEPAVSYYIEDEDTKILFDTGYSDIFLKNSAALGVDLKNIDIIAVSHGHNDHTGGLKYYFQKNCKNKISILAHPDAFKEKIDGDLKICSSILEEELKEKCNLILSKEPKKVSKHITFLGEIPRTNDFENKKPIGKQVSGKALVDDYVMDDTALVYKSQKGIYVITGCSHSGICNIVEYAKKVCSDNRVLGIIGGFHLFQVNSGVRKTIEYLRKSDVKELYPCHCTSFAVKAEIHKYLPIKEVGVGLEINW
>NC_022592.1|WP_023162219.1|1486525_1487278_-|3-oxoacyl-[acyl-carrier-protein]-reductase
MMDLGLTDKVALITGGIRGLGRAIAEKLAAEKVKIVVTGTNEERAKKAADEISSAYGVEALGLKHDVSSEESTKEVVKSVIAKFKKIDILINNAGVTSDGIVMTMKKENWDKVINTNLTGTFNCTKLVSKQMLRQRSGSIVNIASVVGIIGNVGQANYAASKAGVIGFTKATARELAGRGIVVNAVAPGYISTDMTSVLSDKVTEEMLSKIPMKAYGKAENVANAVLFLVSNMCQYITGQVINVDGGMAM
>NC_022592.1|WP_023162218.1|1486116_1486491_-|hypothetical-protein
MTYFTRIISIVFLVSTAISFFIAYRGIRNKFAAKFLMAYLFFAFFYILYMLLVAVINLKKLKWIEVKKRTLRLMLLFALFSILDCIFYYIFGITNRSLLSGIWMSLALAFGMSFMDIVFKKNNT
>NC_022592.1|WP_013240116.1|1485207_1485837_-|YhbD-family-protein
MEEENLISKKELLKVTGISYGQLYRWKRKKLIPEEWFIKRSSFTGQETFFPRKEILDRVEKIKNFKDDVSLDELASIFSPNLSKVILKESDISSHNIVSQPTFTLYKDVHKESSEFNFNELLFMTIVDRFLKSGKVSLGEAKLVLDTLEKNYEKFYGRYCDVVLIRKLGVAVCFLMLIPNEVYVETEAMLVLKINAGECVEQLKSKLTL
>NC_022592.1|WP_013240115.1|1484459_1485188_-|polymer-forming-cytoskeletal-protein
MEENLQDVKISGAGIIRGGKYDEVKISGTAKMNGDIECSSYKVSGSSNVSGNLKSKITKISGSTKICGNLDCEEITVSGSSHIVGSVTAKKVKISGSSRMDSNLHTEEISISGSASISGDCEAENFNARGGFNIDGLLNAGNIDIEMYGKCTVKDIGGENISVKLGEGHFFMKMINLFSNSARLVTGTIEGDDIYLENTCAKVVRGNNVTIGANCDIEIVEYRNKVDVGKNSKIVCKKIADN
>NC_022592.1|WP_023162217.1|1483621_1484215_-|TetR/AcrR-family-transcriptional-regulator
MKTDKSQITKEIILEKTLQLVDENEGIKNVTLRDIAKKVGCSHTNLYNYFGSLSEILWEALGQVLIKMINYSRDNLTFKDDPEKDYYVLLSNFIDFSLDHIGLYKLLRMESIDGEPPSEVMNIVASARKEFDKNILEAARGKLLEERASFVSDVFFAYLHGEISLWINKRRLMVSKEDTKAKILSNLKQLFQELVIR
>NC_022592.1|WP_013240113.1|1483054_1483597_-|NAD(P)H-dependent-oxidoreductase
MKRVLQVVLILLVVIIVGTILFFKWVVNANSIVHKSDERKLLLSSSSKKALVIYQPSRTKLTSTMASSIAETLQKSGYEVTINYPSQELNYDISKYDVLVFGTPIYVGKYSTVLESYMKAIKDFSNKRVMIFSTGGDNKVTKEIDPLVQLAKGADKVEGIKLLKGQTTKAADAIKNLTGE
>NC_022592.1|WP_023162216.1|1482437_1483049_-|CDP-alcohol-phosphatidyltransferase-family-protein
MKKYLRYAVPNFITLLRVVLTGIFTLFLNRKLALDGNDELFTYLVMIFFAICVTDFIDGRIARYFKSVSSFGSFLDVLADFLFILCATGILIKYKLIAWWFLIVIIAKIIDFFVTSKIMNKYKSEKNKTFVFDFMGRAAAISFYIMPFIVLSMNEYLKGRCIFPVLFLTYISTIIALISLFQRIILCIQIKRRQAVKHDGSII
>NC_022592.1|WP_013240111.1|1480968_1481961_-|ABC-transporter-substrate-binding-protein
MKFKKIAALAATAVLTIGIFAGCGGASQQTSSSNSSSKKKVIGFAQVGAESGWRTAETTSIKEIPKLDPNFELKFSDGQQKQENQIKAIRSFIAEKVDIIALDPVVETGWDTVLREAKNAKIPVVIVDRNVKVADNSLVTAFLGSDMEEEGKRAAKIVIDKFGKDAKLNIAELQGTVGSTAMIGRQKGFNETIKDCPNYKIIKSQTGDFTRAKGKEVMEAFLKSDGNKINVLWSHNDDMAVGAIQAIEEYGKKPGKDIFIVSVDGIKDMFKLMADGKSNGIVECNPLLGPQLLETSKQVLSGKLKDKIVHTKEGVFTQDQAKKELPNRKY
>NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2
MGKNFNFNYAFVFYDVNEKRVNKVFKVCKKYFHHHQNSVFRGAITTSKMIKLKSELNKIIKDKDFVTIIKLMNDSCFEEDTLGINENNTEDLIL
>NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MASGTKYLMSMGELKRKDNSVLFHNEKGNFYLPIESTREIYCMNEITVNSKFLDFAAKAGIVIHFFNYYGYYSGSFYPKESLVSGKVTIKQVEAFLNNRNYIAKSFVWGIGENICQILYHYYRHDKKEVEPTINWIKEKVPEYLEDGNLGIKQVLRVEGEIWQRFYENFKYILPEDFIMNKRVKRPPDNPINALISFGNSILYSKTVSQIYNTHLNQTISYLHEPSEGRFSLSLDLSEVFKPVIVYRTIFELVNTKQIQVNKHFDKKYNYCLLNEEGKKIFVQAIEQRFESVFDHKKLKRKISYKTAIRLDGYKLIKYVVEGEEFKPFSLKNMM
>NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4
MKINGTLINYYFHCKRQFWLHANRINMEYTNEDVKIGKVIHELKAEGNKNAEICIDNVKIDKITKDYLVEIKKSDADVEAVKWQVLFYLSILKNKGIYREGKIEFQEKNKQDKKIIYVSLTEENEMKLKELNLEMEKLLEKDMPPKVGKVKGCKKCAYYEYCYI
>NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3
MYFDDVELFNPEFFISNLDNMYAHRDRTDKTRREKLTDHINLTYKYFEFICSEKDLDNVFNNLQKDILEDRCEDVICLWKEMLANTIYMHDIGKINPAFQYANMLNKLYKDNSAGEKNHSLLGSYIYVSYFNGRINKIKKRYDRYYLKYFMYLNSYIISRHHGFLGSIEGYGEKLKNFSENYKKETYYPDLNMDVLGERVIYKSFCNSQEYIKDCFLANSKLDFTLYIYSKLLFSILTAADYYATSQFMNGEKVDDMGIMDDELKKRFSRDVEDYDILKSIRSYEKNPVIDGKYSNINQLRSKITLESEKSYLKNRNKNIYYLEAPTGAGKTITSINLVRHMLNSNEKINKLFYVFPFNTLVEQTESAFIKIFKNDSKIRESISVINSITPIKTVDKDYEVESDLDSGRKTDYEKSLLNRIFINYPFVITTHVNLFNSLFGTSRKEVFPLINLCNSIIILDEIQSYKNEIWKEIINFLDSYSELLNIKVIIMSATLPRLNKLVEGNSNDFIYLIEDRNKYFKNPYFKSRVKFEMLDLGDEEEQFEKLSRDIQAESRDNGKILIEFIFKKRADRFFDYMNKNFENKYGHEIKIMTADDNKIDRGKIVKMARDKEKKIILIATQIVEAGIDIDMDLGYKNISILDAEEQFMGRVNRSCLKKGRVKFFKIDDCRVIYKGDVRREKELTLIQSEIQKLLGEKDFEKYYEKVIEKIKLKKQESNDHGYEAFTKKLDSMNFKAVQDYMKLIDEDQNKYTVFISREIKLGNNDVIYGDDIWKEYKDVLMDKSMGYAEKKVKLSKITPNLGYFIYKVKEIPTEYSDMLGDIYYISDGEKYIRDGRFNQEIFIGEAPDEANLFM
>NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5
MKVVRFKLSGKTAFFKKPDVNTYCCFTYGNIHKIALLGIMGSVLGFRGYNEQSRNFKKNVYPEFYEKLKNAKVAVVTINKHGYISKKVQEFNNSVGYASRESGGNLIVKQQWLQNPKWMIYVKIDNITDEFSNMIRKNKAKFIPYLGTNDHFADITKVSELEVHKEDDVDKVDSIFETKYFKIDKYQDEEEDTDTAWKYTEYLPVALDKDLNQYQFSDFTETNMAVDSFNESVDVYRDEELDKNLYFF
>NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7
MNRVYGVIGIKSIMANWNADFSGYPKTISDGSIFGSDKALKYSIKKYWEDRGEKILYIKSFKTDKGKIRPRSLEERYNQVFDTTLTKKDESTVILKNLFSALDVKSFGATFAEEGNNISLTGAVQIGQGFNVYEDSNAEEQQILSPFRSDKKPKEGKEAEEANQSTLGTKIVSDEAHYMYPFYINPTSYRDYVDMKVTEGYTEEDYKKFKEGALLGATALNTNAKAGCENEFALFVETDEETYLPNLTQFMKFEKRKDKEILTLNLEEILQGIEDDIKKIEIYYNDYKLKLNNIPKGAVLFNIFTRKEV
>NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein
MINEICKIFSSEYGKKGDALIVDNYTLSPGDYVEFTLEDSGDRVEIFSVDKKTDKSQDDYRKFAKMDCISGLISMNKPVDPTKVIHSNNMYTFYVKKENLDPSKGKLNVEIIDKYYDILKNPKDKYKNKKKSLELYLKFEKEQGKPDGELIDKIRDWIKQNIYKIASRKSLDKTYLKLFYNTDSKNYERESQRYIIPNIYNSTDYNVKIGDKVYGLPDFNIGLNSKKPYLENKTRKSKLPVLVDSSTISMEKKLFDYFMNYAQEKKNYIYAGSDIDAVDYKENKKDDFKGYFLRINKGKEAEIADYDTITEYRYKLKRSIEVLPIINGGAGKDFELFLGVLNNLGEVKSRISEVFFNKYLENNFFTEAKSINLNDARVKECLLKYRYGLYTWFYKGEDFLASTFWNSMTLYLLCNSINQGNINKAVNQFNLRHAVLYYFNNEKGGKSMDAVVKSVRKSIDEKINIKEDPEYKVEAENDEEYYFCIGQLLKYFYSLNKSGNKSYSFINPFLNAKSSEFIKEKLRKLFIKYDYAIQSSFRFNNMYYMVSSYNTEGKVDQDIIIAGFLCPNLIYKKSEKENQNEEAN
>NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein
MEINQINIKVYILENISIEQALEDLSKLMDKSFYENEDMKNFHEENMMKNYCFNSLYPLDVKTKMYKEGGIYNFQLRCIGSKLKNHFLKFLSNEYTSKIKVLVCQSKNIPKRPMDRIYSITPVIVKMPGSEKTEYWRNEYTEEEFFEYIRTTSIKKYEVLTGEAVDKNLKLFNYAKIDNKKPIAASFKDKRILGDKVTLNLETNSDAQNIAYMLLGTGLADMSPRGYGFVNYQYIK
>NC_022592.1|WP_023162231.1|1503044_1503806_-|CPBP-family-intramembrane-metalloprotease
MVVDGLVNAFINITLFIIVIMLVKKIESIRNKDYTPVYWISLKKHDIKLFVIGIIVALLYKLAVGSIGIIGGTMELIVNGPGMAKFIIFTLASSFGFLGVALFEEGLYRGYVMQVAFRKLPKVLAIVLQALVFGLVHYSNYSKQPHTWIRIIDAILIGVIFGVIVIKTKSLMFTVGTHLFYDATEQMLFLDNPYKFTRFICFQNTNYLSSSLFYTEFIELSMLSILTVVLIFLFRKNLFYDKSFSTNLRSKGA
>NC_022592.1|WP_023162232.1|1503835_1504351_-|hypothetical-protein
MIKKLHGYLINLSIFKFILITSIIPFFISYIASLVIKNYVRQFPNDILKVNNSLITNVSFTINGIFIAPLVETFIFVIIISIFLYYSYSQTIQIIAVIVAAICFGIPHFFNTNDMIWGLYWAIQAGIKGLILGYAFMVYFFKSKRIDVAGFVVFLIHSINNLLGIIISLIF

Crispr_ID: NC_022592_4

• CRISPR_ID: NC_022592_4
• CRISPR_location: 1499908-1502711
• CRISPR_type: TypeI-B
• Repeat_type: II-B
• Spacer_info: 42 spacers
• Cas_protein_info: cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2

Consensus repeat of NC_022592_4

Consensus_repeat	Method
ATTTAAATACATCTCATGTTGAGGTTCAAC	CRISPRCasFinder
ATTTAAATACATCTCATGTTGAGGTTCAAC	CRT
ATTTAAATACATCTCATGTTGAGGTTCAAC	PILER-CR

spacers of NC_022592_4

>4.1|1499938|36|NC_022592|CRISPRCasFinder,CRT
AATTCCTTTATAATGTATTATTTACAATTATTATTT
>4.2|1500004|37|NC_022592|CRISPRCasFinder,CRT
TTATAGCTCCAGACGAGGAAAATGCCAGAGATTATTA
>4.3|1500071|37|NC_022592|CRISPRCasFinder,CRT
TAAAAAATAGACCATATACTTCTTTAAAAGATTTTCA
>4.4|1500138|34|NC_022592|CRISPRCasFinder,CRT
CAACTATAGAGCCACTTGGAAGGGTAATTAAGTT
>4.5|1500202|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTGAAATACTTGATATGTATCCTAATGATGGAAGTTT
>4.6|1500269|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTATAAATAGAAACTTCACAAAAGATCCTAAATCCAC
>4.7|1500336|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTTAATTTTCGCCAATTCTACATTACTATATTTCA
>4.8|1500401|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTTATTGTTTACTTTATCAGTATTTGCATTGACTT
>4.9|1500466|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TATGGAAGAAATAAGACTTTTAACAGCAAATGAAAT
>4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR
CGTCACAAAAGAAGAAATAGAAAAAATTGTAGATGAA
>4.11|1500599|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GCAGATACAAAGAAGAAGGATTCCCTTGGGCAAGAA
>4.12|1500665|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR
AAAATCAAATAAACCTATTGAATGGATAATCTCCCAG
>4.13|1500732|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
ATCATTATTGAAAGCTCTTATCCTTTATTCGATTTA
>4.14|1500798|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
ATGCCGTGCAATCAGACTGGATGGTCTACTATTTA
>4.15|1500863|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
AAACATTTCTTAGATGCTATATCTGGTTATGTAAG
>4.16|1500928|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTTTAGGTACTGGTATTATTTTTGCTCCATATTATTG
>4.17|1500995|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
AGTCTAGGCTTCAGCAATTTTAAGAAGGTAAAAAAA
>4.18|1501061|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GGAGGCAGTAAATGATCTTGGACATACGCCTGTAAG
>4.19|1501127|38|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TAGGACAAGGTAGAGATATGGATTTTTCTGCTTACAAA
>4.20|1501195|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TGAAAAAGAAGGAGATAACCCAACTCAAAATAGTAAG
>4.21|1501262|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTAATATCTCATCTATCATATTATACTTCCTTTCCA
>4.22|1501328|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTAAATAATTAGTATAAAAATGGAGGAATGTATAAA
>4.23|1501394|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TATTGGCCAAACTTTAAATATACATCTGCAATGTC
>4.24|1501459|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
CTCTATAGCAGTTCAATTTCATCCTGATCTAATCCC
>4.25|1501525|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TAGACCACAATTAAATGCAATGTTAGAATTTGCTCG
>4.26|1501591|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTTTAAAGATAGTATAACTAAGCAACAAAATGATTA
>4.27|1501657|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
CGATAAAAGACACACTCAAAACTGTATGGGATGCTA
>4.28|1501723|38|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTTGGCTTACTACTTATAGCAGTTCCAACAGTTATTAC
>4.29|1501791|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
AAAGCTTCGGCATATAAAAGTTGGAGCTTTATACTG
>4.30|1501857|34|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTAAGCAGTTTAAGCCATTGTATCGAGTAGACTG
>4.31|1501921|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GTTGGTGGAGAAAAGGAACCTCTATTACTAGAAAA
>4.32|1501986|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TGATAACTTAATAAAAAATATAGAGTTAAAAAAAGG
>4.33|1502052|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GGTGCTAAAGATACTGGATTAGGAATAATTACATCA
>4.34|1502118|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GCCCACTATTTTGTGTATAATTTATTACTCCAAACA
>4.35|1502184|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TACATTCTCTACTACAGAATAATCGAATTTTACCTG
>4.36|1502250|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
ATAATGGATAAGATAATATTATATTAGTCATTTTTT
>4.37|1502316|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
ATTGGTTAGGCTCAAAATTCCTAGCGTTTTGTCCTT
>4.38|1502382|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTTGCACAACTTCGTTAAAACATAATTTAGCGAAGT
>4.39|1502448|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
AAATGAAAACATATGTTTTACACCTTATCAAGTTGG
>4.40|1502514|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
AATAATAGCAGTAATTTTATTAATTACAGGCATATA
>4.41|1502580|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
ATGTATAAATAAAGAAACAAACCAAATTGTAGAATA
>4.42|1502646|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GCAGCTCCAGGAGCAAAAACCAAAGGTACTATTCGC

CRISPR arrays and Neighbor proteins around NC_022592_4

CRISPR arrays

The CRISPR arrays of NC_022592_4

>merge|NC_022592|4|1499908-1502711|CRISPRCasFinder,CRT,PILER-CR
ATTTAAAAACATTTCATATTATGGTTCAATAATTCCTTTATAATGTATTATTTACAATTATTATTTATTTAATCACATCTCATGTTGAAGTTCAACTTATAGCTCCAGACGAGGAAAATGCCAGAGATTATTAATTTAAATACATCCCATGTTAAGGTTCAATTAAAAAATAGACCATATACTTCTTTAAAAGATTTTCAATTTAAATACATCCCATGTTAAGGTTCAACCAACTATAGAGCCACTTGGAAGGGTAATTAAGTTATTTAAATACATCTCATGTTGAGGTTCAACTTGAAATACTTGATATGTATCCTAATGATGGAAGTTTATTTAAATACATCTCATGTTGAGGTTCAACTTATAAATAGAAACTTCACAAAAGATCCTAAATCCACATTTAAATACATCTCATGTTGAGGTTCAACTTTAATTTTCGCCAATTCTACATTACTATATTTCAATTTAAATACATCTCATGTTGAGGTTCAACTTTATTGTTTACTTTATCAGTATTTGCATTGACTTATTTAAATACATCTCATGTTGAGGTTCAACTATGGAAGAAATAAGACTTTTAACAGCAAATGAAATATTTAAATACATCTCATGTTGAGGTTCAACCGTCACAAAAGAAGAAATAGAAAAAATTGTAGATGAAATTTAAATACATCTCATGTTGAGGTTCAACGCAGATACAAAGAAGAAGGATTCCCTTGGGCAAGAAATTTAAATACATCTCATGTTGAGGTTCAACAAAATCAAATAAACCTATTGAATGGATAATCTCCCAGATTTAAATACATCTCATGTTGAGGTTCAACATCATTATTGAAAGCTCTTATCCTTTATTCGATTTAATTTAAATACATCTCATGTTGAGGTTCAACATGCCGTGCAATCAGACTGGATGGTCTACTATTTAATTTAAATACATCTCATGTTGAGGTTCAACAAACATTTCTTAGATGCTATATCTGGTTATGTAAGATTTAAATACATCTCATGTTGAGGTTCAACTTTTAGGTACTGGTATTATTTTTGCTCCATATTATTGATTTAAATACATCTCATGTTGAGGTTCAACAGTCTAGGCTTCAGCAATTTTAAGAAGGTAAAAAAAATTTAAATACATCTCATGTTGAGGTTCAACGGAGGCAGTAAATGATCTTGGACATACGCCTGTAAGATTTAAATACATCTCATGTTGAGGTTCAACTAGGACAAGGTAGAGATATGGATTTTTCTGCTTACAAAATTTAAATACATCTCATGTTGAGGTTCAACTGAAAAAGAAGGAGATAACCCAACTCAAAATAGTAAGATTTAAATACATCTCATGTTGAGGTTCAACTTAATATCTCATCTATCATATTATACTTCCTTTCCAATTTAAATACATCTCATGTTGAGGTTCAACTTAAATAATTAGTATAAAAATGGAGGAATGTATAAAATTTAAATACATCTCATGTTGAGGTTCAACTATTGGCCAAACTTTAAATATACATCTGCAATGTCATTTAAATACATCTCATGTTGAGGTTCAACCTCTATAGCAGTTCAATTTCATCCTGATCTAATCCCATTTAAATACATCTCATGTTGAGGTTCAACTAGACCACAATTAAATGCAATGTTAGAATTTGCTCGATTTAAATACATCTCATGTTGAGGTTCAACTTTTAAAGATAGTATAACTAAGCAACAAAATGATTAATTTAAATACATCTCATGTTGAGGTTCAACCGATAAAAGACACACTCAAAACTGTATGGGATGCTAATTTAAATACATCTCATGTTGAGGTTCAACTTTGGCTTACTACTTATAGCAGTTCCAACAGTTATTACATTTAAATACATCTCATGTTGAGGTTCAACAAAGCTTCGGCATATAAAAGTTGGAGCTTTATACTGATTTAAATACATCTCATGTTGAGGTTCAACTTAAGCAGTTTAAGCCATTGTATCGAGTAGACTGATTTAAATACATCTCATGTTGAGGTTCAACGTTGGTGGAGAAAAGGAACCTCTATTACTAGAAAAATTTAAATACATCTCATGTTGAGGTTCAACTGATAACTTAATAAAAAATATAGAGTTAAAAAAAGGATTTAAATACATCTCATGTTGAGGTTCAACGGTGCTAAAGATACTGGATTAGGAATAATTACATCAATTTAAATACATCTCATGTTGAGGTTCAACGCCCACTATTTTGTGTATAATTTATTACTCCAAACAATTTAAATACATCTCATGTTGAGGTTCAACTACATTCTCTACTACAGAATAATCGAATTTTACCTGATTTAAATACATCTCATGTTGAGGTTCAACATAATGGATAAGATAATATTATATTAGTCATTTTTTATTTAAATACATCTCATGTTGAGGTTCAACATTGGTTAGGCTCAAAATTCCTAGCGTTTTGTCCTTATTTAAATACATCTCATGTTGAGGTTCAACTTTGCACAACTTCGTTAAAACATAATTTAGCGAAGTATTTAAATACATCTCATGTTGAGGTTCAACAAATGAAAACATATGTTTTACACCTTATCAAGTTGGATTTAAATACATCTCATGTTGAGGTTCAACAATAATAGCAGTAATTTTATTAATTACAGGCATATAATTTAAATACATCTCATGTTGAGGTTCAACATGTATAAATAAAGAAACAAACCAAATTGTAGAATAATTTAAATACATCTCATGTTGAGGTTCAACGCAGCTCCAGGAGCAAAAACCAAAGGTACTATTCGCATTTAAATACATCTCATGTTGAGGTTCAAC

>NC_022592|4|3|1499908-1502711|CRISPRCasFinder
ATTTAAAAACATTTCATATTATGGTTCAAT	AATTCCTTTATAATGTATTATTTACAATTATTATTT
ATTTAATCACATCTCATGTTGAAGTTCAAC	TTATAGCTCCAGACGAGGAAAATGCCAGAGATTATTA
ATTTAAATACATCCCATGTTAAGGTTCAAT	TAAAAAATAGACCATATACTTCTTTAAAAGATTTTCA
ATTTAAATACATCCCATGTTAAGGTTCAAC	CAACTATAGAGCCACTTGGAAGGGTAATTAAGTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTGAAATACTTGATATGTATCCTAATGATGGAAGTTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTATAAATAGAAACTTCACAAAAGATCCTAAATCCAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTAATTTTCGCCAATTCTACATTACTATATTTCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTATTGTTTACTTTATCAGTATTTGCATTGACTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TATGGAAGAAATAAGACTTTTAACAGCAAATGAAAT
ATTTAAATACATCTCATGTTGAGGTTCAAC	CGTCACAAAAGAAGAAATAGAAAAAATTGTAGATGAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCAGATACAAAGAAGAAGGATTCCCTTGGGCAAGAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAAATCAAATAAACCTATTGAATGGATAATCTCCCAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATCATTATTGAAAGCTCTTATCCTTTATTCGATTTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATGCCGTGCAATCAGACTGGATGGTCTACTATTTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAACATTTCTTAGATGCTATATCTGGTTATGTAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTTAGGTACTGGTATTATTTTTGCTCCATATTATTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	AGTCTAGGCTTCAGCAATTTTAAGAAGGTAAAAAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGAGGCAGTAAATGATCTTGGACATACGCCTGTAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TAGGACAAGGTAGAGATATGGATTTTTCTGCTTACAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TGAAAAAGAAGGAGATAACCCAACTCAAAATAGTAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAATATCTCATCTATCATATTATACTTCCTTTCCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAAATAATTAGTATAAAAATGGAGGAATGTATAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TATTGGCCAAACTTTAAATATACATCTGCAATGTC
ATTTAAATACATCTCATGTTGAGGTTCAAC	CTCTATAGCAGTTCAATTTCATCCTGATCTAATCCC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TAGACCACAATTAAATGCAATGTTAGAATTTGCTCG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTTAAAGATAGTATAACTAAGCAACAAAATGATTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	CGATAAAAGACACACTCAAAACTGTATGGGATGCTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTGGCTTACTACTTATAGCAGTTCCAACAGTTATTAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAAGCTTCGGCATATAAAAGTTGGAGCTTTATACTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAAGCAGTTTAAGCCATTGTATCGAGTAGACTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	GTTGGTGGAGAAAAGGAACCTCTATTACTAGAAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TGATAACTTAATAAAAAATATAGAGTTAAAAAAAGG
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGTGCTAAAGATACTGGATTAGGAATAATTACATCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCCCACTATTTTGTGTATAATTTATTACTCCAAACA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TACATTCTCTACTACAGAATAATCGAATTTTACCTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATAATGGATAAGATAATATTATATTAGTCATTTTTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATTGGTTAGGCTCAAAATTCCTAGCGTTTTGTCCTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTGCACAACTTCGTTAAAACATAATTTAGCGAAGT
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAATGAAAACATATGTTTTACACCTTATCAAGTTGG
ATTTAAATACATCTCATGTTGAGGTTCAAC	AATAATAGCAGTAATTTTATTAATTACAGGCATATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATGTATAAATAAAGAAACAAACCAAATTGTAGAATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCAGCTCCAGGAGCAAAAACCAAAGGTACTATTCGC
ATTTAAATACATCTCATGTTGAGGTTCAAC

>NC_022592|4|2|1499908-1502711|CRT
ATTTAAAAACATTTCATATTATGGTTCAAT	AATTCCTTTATAATGTATTATTTACAATTATTATTT
ATTTAATCACATCTCATGTTGAAGTTCAAC	TTATAGCTCCAGACGAGGAAAATGCCAGAGATTATTA
ATTTAAATACATCCCATGTTAAGGTTCAAT	TAAAAAATAGACCATATACTTCTTTAAAAGATTTTCA
ATTTAAATACATCCCATGTTAAGGTTCAAC	CAACTATAGAGCCACTTGGAAGGGTAATTAAGTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTGAAATACTTGATATGTATCCTAATGATGGAAGTTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTATAAATAGAAACTTCACAAAAGATCCTAAATCCAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTAATTTTCGCCAATTCTACATTACTATATTTCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTATTGTTTACTTTATCAGTATTTGCATTGACTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TATGGAAGAAATAAGACTTTTAACAGCAAATGAAAT
ATTTAAATACATCTCATGTTGAGGTTCAAC	CGTCACAAAAGAAGAAATAGAAAAAATTGTAGATGAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCAGATACAAAGAAGAAGGATTCCCTTGGGCAAGAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAAATCAAATAAACCTATTGAATGGATAATCTCCCAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATCATTATTGAAAGCTCTTATCCTTTATTCGATTTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATGCCGTGCAATCAGACTGGATGGTCTACTATTTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAACATTTCTTAGATGCTATATCTGGTTATGTAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTTAGGTACTGGTATTATTTTTGCTCCATATTATTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	AGTCTAGGCTTCAGCAATTTTAAGAAGGTAAAAAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGAGGCAGTAAATGATCTTGGACATACGCCTGTAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TAGGACAAGGTAGAGATATGGATTTTTCTGCTTACAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TGAAAAAGAAGGAGATAACCCAACTCAAAATAGTAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAATATCTCATCTATCATATTATACTTCCTTTCCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAAATAATTAGTATAAAAATGGAGGAATGTATAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TATTGGCCAAACTTTAAATATACATCTGCAATGTC
ATTTAAATACATCTCATGTTGAGGTTCAAC	CTCTATAGCAGTTCAATTTCATCCTGATCTAATCCC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TAGACCACAATTAAATGCAATGTTAGAATTTGCTCG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTTAAAGATAGTATAACTAAGCAACAAAATGATTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	CGATAAAAGACACACTCAAAACTGTATGGGATGCTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTGGCTTACTACTTATAGCAGTTCCAACAGTTATTAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAAGCTTCGGCATATAAAAGTTGGAGCTTTATACTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAAGCAGTTTAAGCCATTGTATCGAGTAGACTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	GTTGGTGGAGAAAAGGAACCTCTATTACTAGAAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TGATAACTTAATAAAAAATATAGAGTTAAAAAAAGG
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGTGCTAAAGATACTGGATTAGGAATAATTACATCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCCCACTATTTTGTGTATAATTTATTACTCCAAACA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TACATTCTCTACTACAGAATAATCGAATTTTACCTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATAATGGATAAGATAATATTATATTAGTCATTTTTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATTGGTTAGGCTCAAAATTCCTAGCGTTTTGTCCTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTGCACAACTTCGTTAAAACATAATTTAGCGAAGT
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAATGAAAACATATGTTTTACACCTTATCAAGTTGG
ATTTAAATACATCTCATGTTGAGGTTCAAC	AATAATAGCAGTAATTTTATTAATTACAGGCATATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATGTATAAATAAAGAAACAAACCAAATTGTAGAATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCAGCTCCAGGAGCAAAAACCAAAGGTACTATTCGC
ATTTAAATACATCTCATGTTGAGGTTCAAC

>NC_022592|4|3|1500172-1502711|PILER-CR
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTGAAATACTTGATATGTATCCTAATGATGGAAGTTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTATAAATAGAAACTTCACAAAAGATCCTAAATCCAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTAATTTTCGCCAATTCTACATTACTATATTTCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTATTGTTTACTTTATCAGTATTTGCATTGACTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TATGGAAGAAATAAGACTTTTAACAGCAAATGAAAT
ATTTAAATACATCTCATGTTGAGGTTCAAC	CGTCACAAAAGAAGAAATAGAAAAAATTGTAGATGAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCAGATACAAAGAAGAAGGATTCCCTTGGGCAAGAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAAATCAAATAAACCTATTGAATGGATAATCTCCCAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATCATTATTGAAAGCTCTTATCCTTTATTCGATTTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATGCCGTGCAATCAGACTGGATGGTCTACTATTTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAACATTTCTTAGATGCTATATCTGGTTATGTAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTTAGGTACTGGTATTATTTTTGCTCCATATTATTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	AGTCTAGGCTTCAGCAATTTTAAGAAGGTAAAAAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGAGGCAGTAAATGATCTTGGACATACGCCTGTAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TAGGACAAGGTAGAGATATGGATTTTTCTGCTTACAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TGAAAAAGAAGGAGATAACCCAACTCAAAATAGTAAG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAATATCTCATCTATCATATTATACTTCCTTTCCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAAATAATTAGTATAAAAATGGAGGAATGTATAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TATTGGCCAAACTTTAAATATACATCTGCAATGTC
ATTTAAATACATCTCATGTTGAGGTTCAAC	CTCTATAGCAGTTCAATTTCATCCTGATCTAATCCC
ATTTAAATACATCTCATGTTGAGGTTCAAC	TAGACCACAATTAAATGCAATGTTAGAATTTGCTCG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTTAAAGATAGTATAACTAAGCAACAAAATGATTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	CGATAAAAGACACACTCAAAACTGTATGGGATGCTA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTGGCTTACTACTTATAGCAGTTCCAACAGTTATTAC
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAAGCTTCGGCATATAAAAGTTGGAGCTTTATACTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTAAGCAGTTTAAGCCATTGTATCGAGTAGACTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	GTTGGTGGAGAAAAGGAACCTCTATTACTAGAAAA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TGATAACTTAATAAAAAATATAGAGTTAAAAAAAGG
ATTTAAATACATCTCATGTTGAGGTTCAAC	GGTGCTAAAGATACTGGATTAGGAATAATTACATCA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCCCACTATTTTGTGTATAATTTATTACTCCAAACA
ATTTAAATACATCTCATGTTGAGGTTCAAC	TACATTCTCTACTACAGAATAATCGAATTTTACCTG
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATAATGGATAAGATAATATTATATTAGTCATTTTTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATTGGTTAGGCTCAAAATTCCTAGCGTTTTGTCCTT
ATTTAAATACATCTCATGTTGAGGTTCAAC	TTTGCACAACTTCGTTAAAACATAATTTAGCGAAGT
ATTTAAATACATCTCATGTTGAGGTTCAAC	AAATGAAAACATATGTTTTACACCTTATCAAGTTGG
ATTTAAATACATCTCATGTTGAGGTTCAAC	AATAATAGCAGTAATTTTATTAATTACAGGCATATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	ATGTATAAATAAAGAAACAAACCAAATTGTAGAATA
ATTTAAATACATCTCATGTTGAGGTTCAAC	GCAGCTCCAGGAGCAAAAACCAAAGGTACTATTCGC
ATTTAAATACATCTCATGTTGAGGTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_022592.1|WP_023162220.1|1487419_1488226_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293799
NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl|CDD|188234
NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|350688
NC_022592.1|WP_023162234.1|1506959_1507358_+|polyketide-cyclase/dehydrase	unknown	unknown	gnl|CDD|176866
NC_022592.1|WP_158212035.1|1488450_1488678_-|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_013240126.1|1509131_1510010_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
NC_022592.1|WP_023162236.1|1507906_1508449_-|nitroreductase-family-protein	unknown	unknown	gnl|CDD|380316
NC_022592.1|WP_029169904.1|1507372_1507879_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|379082
NC_022592.1|WP_029169905.1|1511755_1512193_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_022592.1|WP_023162232.1|1503835_1504351_-|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_022592.1|WP_013240129.1|1512633_1513203_+|energy-coupling-factor-transporter-S-component-ThiW	unknown	unknown	gnl|CDD|370540
NC_022592.1|WP_013240127.1|1510165_1511620_+|MFS-transporter	unknown	unknown	gnl|CDD|129794
NC_022592.1|WP_013240125.1|1508652_1509117_+|DUF1648-domain-containing-protein	unknown	unknown	gnl|CDD|377929
NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl|CDD|131641
NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_022592.1|WP_023162231.1|1503044_1503806_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	7.7e-45	147.7	9.7
NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	5.4e-30	99.5	0.3
NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein	cas6	cd09652_cas6_CAS-I:CAS-III	6.8e-12	40.9	3.1
NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	2e-175	579.7	63.4
NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	4.7e-125	411.7	10.9
NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	1.4e-37	124.2	7.8
NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-50	166.6	5.5
NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.1e-24	81.2	0.7

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.24266e-48
NC_022592.1|WP_023162220.1|1487419_1488226_-|MBL-fold-metallo-hydrolase	gnl|CDD|293799	cd07713, DHPS-like_MBL-fold, Methanocaldococcus jannaschii dihydropteroate synthase, Thermoanaerobacter tengcongensis Tflp, and related proteins; MBL-fold metallo hydrolase domain. This subgroup includes Methanocaldococcus jannaschii 7,8-dihydropterin-6-methyl-4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate synthase (EC 2.5.1.15), a folate biosynthetic enzyme also known as dihydropteroate synthase and 7,8 dihydropteroate synthase. Thermoanaerobacter tengcongensis Tflp is a ferredoxin-like member. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	6.69226e-101
NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein	gnl|CDD|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	9.63104e-18
NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.06183e-148
NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	2.30789e-29
NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.26285e-22
NC_022592.1|WP_013240126.1|1509131_1510010_-|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.46729e-31
NC_022592.1|WP_023162236.1|1507906_1508449_-|nitroreductase-family-protein	gnl|CDD|380316	cd02139, nitroreductase, nitroreductase family protein. A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.	7.342e-71
NC_022592.1|WP_029169904.1|1507372_1507879_-|AAA-family-ATPase	gnl|CDD|379082	pfam13238, AAA_18, AAA domain.	6.07121e-15
NC_022592.1|WP_029169905.1|1511755_1512193_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.11944e-11
NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.87503e-50
NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	4.92532e-07
NC_022592.1|WP_013240129.1|1512633_1513203_+|energy-coupling-factor-transporter-S-component-ThiW	gnl|CDD|370540	pfam09512, ThiW, Thiamine-precursor transporter protein (ThiW). Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.	6.31826e-48
NC_022592.1|WP_013240127.1|1510165_1511620_+|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.51889e-61
NC_022592.1|WP_013240125.1|1508652_1509117_+|DUF1648-domain-containing-protein	gnl|CDD|377929	pfam07853, DUF1648, Protein of unknown function (DUF1648). Members of this family are hypothetical proteins expressed by either bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues.	0.000118441
NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5	gnl|CDD|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.18725e-44
NC_022592.1|WP_023162234.1|1506959_1507358_+|polyketide-cyclase/dehydrase	gnl|CDD|176866	cd07824, SRPBCC_6, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	5.90696e-05
NC_022592.1|WP_023162231.1|1503044_1503806_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.0633e-13

Protein sequences

>NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein
MEINQINIKVYILENISIEQALEDLSKLMDKSFYENEDMKNFHEENMMKNYCFNSLYPLDVKTKMYKEGGIYNFQLRCIGSKLKNHFLKFLSNEYTSKIKVLVCQSKNIPKRPMDRIYSITPVIVKMPGSEKTEYWRNEYTEEEFFEYIRTTSIKKYEVLTGEAVDKNLKLFNYAKIDNKKPIAASFKDKRILGDKVTLNLETNSDAQNIAYMLLGTGLADMSPRGYGFVNYQYIK
>NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein
MINEICKIFSSEYGKKGDALIVDNYTLSPGDYVEFTLEDSGDRVEIFSVDKKTDKSQDDYRKFAKMDCISGLISMNKPVDPTKVIHSNNMYTFYVKKENLDPSKGKLNVEIIDKYYDILKNPKDKYKNKKKSLELYLKFEKEQGKPDGELIDKIRDWIKQNIYKIASRKSLDKTYLKLFYNTDSKNYERESQRYIIPNIYNSTDYNVKIGDKVYGLPDFNIGLNSKKPYLENKTRKSKLPVLVDSSTISMEKKLFDYFMNYAQEKKNYIYAGSDIDAVDYKENKKDDFKGYFLRINKGKEAEIADYDTITEYRYKLKRSIEVLPIINGGAGKDFELFLGVLNNLGEVKSRISEVFFNKYLENNFFTEAKSINLNDARVKECLLKYRYGLYTWFYKGEDFLASTFWNSMTLYLLCNSINQGNINKAVNQFNLRHAVLYYFNNEKGGKSMDAVVKSVRKSIDEKINIKEDPEYKVEAENDEEYYFCIGQLLKYFYSLNKSGNKSYSFINPFLNAKSSEFIKEKLRKLFIKYDYAIQSSFRFNNMYYMVSSYNTEGKVDQDIIIAGFLCPNLIYKKSEKENQNEEAN
>NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7
MNRVYGVIGIKSIMANWNADFSGYPKTISDGSIFGSDKALKYSIKKYWEDRGEKILYIKSFKTDKGKIRPRSLEERYNQVFDTTLTKKDESTVILKNLFSALDVKSFGATFAEEGNNISLTGAVQIGQGFNVYEDSNAEEQQILSPFRSDKKPKEGKEAEEANQSTLGTKIVSDEAHYMYPFYINPTSYRDYVDMKVTEGYTEEDYKKFKEGALLGATALNTNAKAGCENEFALFVETDEETYLPNLTQFMKFEKRKDKEILTLNLEEILQGIEDDIKKIEIYYNDYKLKLNNIPKGAVLFNIFTRKEV
>NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5
MKVVRFKLSGKTAFFKKPDVNTYCCFTYGNIHKIALLGIMGSVLGFRGYNEQSRNFKKNVYPEFYEKLKNAKVAVVTINKHGYISKKVQEFNNSVGYASRESGGNLIVKQQWLQNPKWMIYVKIDNITDEFSNMIRKNKAKFIPYLGTNDHFADITKVSELEVHKEDDVDKVDSIFETKYFKIDKYQDEEEDTDTAWKYTEYLPVALDKDLNQYQFSDFTETNMAVDSFNESVDVYRDEELDKNLYFF
>NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3
MYFDDVELFNPEFFISNLDNMYAHRDRTDKTRREKLTDHINLTYKYFEFICSEKDLDNVFNNLQKDILEDRCEDVICLWKEMLANTIYMHDIGKINPAFQYANMLNKLYKDNSAGEKNHSLLGSYIYVSYFNGRINKIKKRYDRYYLKYFMYLNSYIISRHHGFLGSIEGYGEKLKNFSENYKKETYYPDLNMDVLGERVIYKSFCNSQEYIKDCFLANSKLDFTLYIYSKLLFSILTAADYYATSQFMNGEKVDDMGIMDDELKKRFSRDVEDYDILKSIRSYEKNPVIDGKYSNINQLRSKITLESEKSYLKNRNKNIYYLEAPTGAGKTITSINLVRHMLNSNEKINKLFYVFPFNTLVEQTESAFIKIFKNDSKIRESISVINSITPIKTVDKDYEVESDLDSGRKTDYEKSLLNRIFINYPFVITTHVNLFNSLFGTSRKEVFPLINLCNSIIILDEIQSYKNEIWKEIINFLDSYSELLNIKVIIMSATLPRLNKLVEGNSNDFIYLIEDRNKYFKNPYFKSRVKFEMLDLGDEEEQFEKLSRDIQAESRDNGKILIEFIFKKRADRFFDYMNKNFENKYGHEIKIMTADDNKIDRGKIVKMARDKEKKIILIATQIVEAGIDIDMDLGYKNISILDAEEQFMGRVNRSCLKKGRVKFFKIDDCRVIYKGDVRREKELTLIQSEIQKLLGEKDFEKYYEKVIEKIKLKKQESNDHGYEAFTKKLDSMNFKAVQDYMKLIDEDQNKYTVFISREIKLGNNDVIYGDDIWKEYKDVLMDKSMGYAEKKVKLSKITPNLGYFIYKVKEIPTEYSDMLGDIYYISDGEKYIRDGRFNQEIFIGEAPDEANLFM
>NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4
MKINGTLINYYFHCKRQFWLHANRINMEYTNEDVKIGKVIHELKAEGNKNAEICIDNVKIDKITKDYLVEIKKSDADVEAVKWQVLFYLSILKNKGIYREGKIEFQEKNKQDKKIIYVSLTEENEMKLKELNLEMEKLLEKDMPPKVGKVKGCKKCAYYEYCYI
>NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MASGTKYLMSMGELKRKDNSVLFHNEKGNFYLPIESTREIYCMNEITVNSKFLDFAAKAGIVIHFFNYYGYYSGSFYPKESLVSGKVTIKQVEAFLNNRNYIAKSFVWGIGENICQILYHYYRHDKKEVEPTINWIKEKVPEYLEDGNLGIKQVLRVEGEIWQRFYENFKYILPEDFIMNKRVKRPPDNPINALISFGNSILYSKTVSQIYNTHLNQTISYLHEPSEGRFSLSLDLSEVFKPVIVYRTIFELVNTKQIQVNKHFDKKYNYCLLNEEGKKIFVQAIEQRFESVFDHKKLKRKISYKTAIRLDGYKLIKYVVEGEEFKPFSLKNMM
>NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2
MGKNFNFNYAFVFYDVNEKRVNKVFKVCKKYFHHHQNSVFRGAITTSKMIKLKSELNKIIKDKDFVTIIKLMNDSCFEEDTLGINENNTEDLIL
>NC_022592.1|WP_158212035.1|1488450_1488678_-|hypothetical-protein
MCDGGASNGSDRIKKQQMYYHKNSYLKFRIILTANISIYRENNAAEKPGERKVAAEICYFTETLKSTANTEREHL
>NC_022592.1|WP_023162220.1|1487419_1488226_-|MBL-fold-metallo-hydrolase
MKLKVLVDNNTYIDRYYFGEPAVSYYIEDEDTKILFDTGYSDIFLKNSAALGVDLKNIDIIAVSHGHNDHTGGLKYYFQKNCKNKISILAHPDAFKEKIDGDLKICSSILEEELKEKCNLILSKEPKKVSKHITFLGEIPRTNDFENKKPIGKQVSGKALVDDYVMDDTALVYKSQKGIYVITGCSHSGICNIVEYAKKVCSDNRVLGIIGGFHLFQVNSGVRKTIEYLRKSDVKELYPCHCTSFAVKAEIHKYLPIKEVGVGLEINW
>NC_022592.1|WP_023162231.1|1503044_1503806_-|CPBP-family-intramembrane-metalloprotease
MVVDGLVNAFINITLFIIVIMLVKKIESIRNKDYTPVYWISLKKHDIKLFVIGIIVALLYKLAVGSIGIIGGTMELIVNGPGMAKFIIFTLASSFGFLGVALFEEGLYRGYVMQVAFRKLPKVLAIVLQALVFGLVHYSNYSKQPHTWIRIIDAILIGVIFGVIVIKTKSLMFTVGTHLFYDATEQMLFLDNPYKFTRFICFQNTNYLSSSLFYTEFIELSMLSILTVVLIFLFRKNLFYDKSFSTNLRSKGA
>NC_022592.1|WP_023162232.1|1503835_1504351_-|hypothetical-protein
MIKKLHGYLINLSIFKFILITSIIPFFISYIASLVIKNYVRQFPNDILKVNNSLITNVSFTINGIFIAPLVETFIFVIIISIFLYYSYSQTIQIIAVIVAAICFGIPHFFNTNDMIWGLYWAIQAGIKGLILGYAFMVYFFKSKRIDVAGFVVFLIHSINNLLGIIISLIF
>NC_022592.1|WP_023162234.1|1506959_1507358_+|polyketide-cyclase/dehydrase
MKESTITTTFKSDIKKVWDVVTNNNKYEWRSDLSKIDVSEDGNSFTEYTKNNFPTKFNITLKKPYERYEFDMTNKNMKGHWIGTFSPANNGTQIEFAEKVSVNNPIMNLFAGLYLKKQQSLYIADLKKELGE
>NC_022592.1|WP_029169904.1|1507372_1507879_-|AAA-family-ATPase
MKNLIFINGTMGVGKTATSKELQKLLPKCVFLDGDWCWNMSPFIVTDETKSMVIDNITYMLNNFISCSEYENIIFCWVMHMQSILDDVLSRINKRGCKVYKFSLICSEKSLIERITKDIENGTRTEDVIDRSVPRLNNYLKMDTDKIDVDEISAKDAAEIIYKRVIAT
>NC_022592.1|WP_023162236.1|1507906_1508449_-|nitroreductase-family-protein
MIEEISTRRSIRKYIDREVENEKILQLIEGARLAPSGSNTQPWHFIVVKSESNRQKISQVCHNQKWMLSAPVFIACVADIRCRIDEKIAVSLDENSPEEELKQIIRDTSISVEHILLGADNLGLGTCWVGWFVQNEIRPILNIPDDKYVVGIVTLGYADEKPKPRPRKKLEEIIHYESWK
>NC_022592.1|WP_013240125.1|1508652_1509117_+|DUF1648-domain-containing-protein
MKIKKNKFDIMVNLLSLLCLVGTVVVLTILWKTIPAKIPGHYNAAGTIDKVTDKNSLIVLLLVGWIIFIGISIVEKFPQIWNTGIQVTEQNKEKVYRILKNMIGTVKLLIASVFSYLTLQSTTGKNLSPLFLPIFLILLFGSIVFFIFQLVKEK
>NC_022592.1|WP_013240126.1|1509131_1510010_-|AraC-family-transcriptional-regulator
MNKSKINYYYKDMPDKNFFVDIFEVKVNKLGATFEENWHEHLQFFYFIQGSALIRCNYKSIHVKAGDFIIVNSNELHYCESLCDNLIYYIIRVDLSFLFSSQMDSCQTKFMVPLAKNLILFKNLVRNDKDILNCADKIIEEYFSKRLGYELAVKAYIYEVIVLLLRKYVEKVLTAGQFNCRVDNLNRLKNIFLYINENFTEKITLDEISEMAHISKEHFCRTFKQITGRSLTNYINNLRIQKADSLLQETDLNITEIALNCGFSDVNYFSRIYKKVKNVSPLNFRKNFCSNL
>NC_022592.1|WP_013240127.1|1510165_1511620_+|MFS-transporter
MEYKNKYGILLVVISMTFMSCLVSNIVNVALPVMSRKLSVPMVSIEWVVASYIISICSTILVFGRLGDVIGKMKVFKFGMVVFTIASFTCGISTSFTELIIFRIIQGIGASAYMANNQGIITQVFPRNERGKALGILASSVALGTLIGSPAGGFITYYLSWNYIFFVNVPIGVIAFIAALKVLPHSKTQNKEINSELDVKGSTFIFLSMVLLFGSLIQGQKVGYNNPIIITIFIVSILFVVVFIVLENKIEKPLIQMKIFKNNVFSLSLFCAFISFVCLNASIIIIPFYLQDAMKLNSSITGLIMMIQPLVMAVISPFSGNLSDKIGSKLLSFLGLLLMSISFIFLSFLNQYSSITKIIIYIVVLGLGQSLFQPSNNSLIMSTVPKNELGIAGSVNSLVRNLGQIIGIILSTSLLYSFMSIKIGYRITDYVTGRDDIFVYGMKYVYIVLTIVCAFGALLTAFRMHNKKSIQTNQSPADIHGKNF
>NC_022592.1|WP_029169905.1|1511755_1512193_+|GNAT-family-N-acetyltransferase
MVTITRITYDDLNDLSNLYEELLGKKTNLQKFKDKFTLINSNKNYILIGAKDSDNTLVGSLLGIICQDLGGECKPFMVVENVIVKNNCRRMGIGKTLMTFIESFARKKDCYFTMLVSAFKRKDAHKFYESIGYNNDVVKGFKKYL
>NC_022592.1|WP_013240129.1|1512633_1513203_+|energy-coupling-factor-transporter-S-component-ThiW
MERNSKLLKKLMLAMMVAMGVVISPILRIEGMCPMSSVINITCAVFFGPWYALLCAVCIGIIRMFLMGIPPLALTGAVFGAFLAGFLYRISKNTLIFAVLGEVIGTGIIGAVVSSPIMTYFWGKKGLSLMFYIPLFFTATIIGGTIAFIFLGTLSKNGMLIKIQKDLGVKVYDKSTDTDKQPIANKTQC

Crispr_ID: NC_022592_5

• CRISPR_ID: NC_022592_5
• CRISPR_location: 1504480-1506686
• CRISPR_type: TypeI-B
• Repeat_type: II-B
• Spacer_info: 33 spacers
• Cas_protein_info: cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2

Consensus repeat of NC_022592_5

Consensus_repeat	Method
ATTTAAATACATCTTATGTTGAGGTTCAAC	CRISPRCasFinder
ATTTAAATACATCTTATGTTGAGGTTCAAC	CRT
ATTTAAATACATCTTATGTTGAGGTTCAAC	PILER-CR

spacers of NC_022592_5

>5.1|1504510|36|NC_022592|CRISPRCasFinder,CRT
AGTAGCTAATGATCAAATATTAACATTCCAATTACT
>5.2|1504576|37|NC_022592|CRISPRCasFinder,CRT
AGGTGGTTATTTTCAAAATAGTTATCAAGCCACACCG
>5.3|1504643|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TATATCAACTCTCCCCACTTTTGGGGAACGTACTCT
>5.4|1504709|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GATGATTATAAAGTATGTTTGCTAACAGCTATAGCGT
>5.5|1504776|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR
ATTTGTACTTGGCTCTGCTATCTTGAATATTAATTTA
>5.6|1504843|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TAATTATATATATTCTGATTGGGTTTATATAAATTC
>5.7|1504909|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
AAGAGTTGATACTTTACTTATAGATTACTTAGGTGC
>5.8|1504975|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GGGCATTAAATATAAAAAGAAATATATTCCATGAAT
>5.9|1505041|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TCTATTACCTTAAGAAAATTAAGTCCACTAGCATTA
>5.10|1505107|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR
CTATCCCAGCAATTAATATCTCTATTAATATCTCTCA
>5.11|1505174|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
ATTGCTCACCCATTTTAAATAGTAATTCCCAAAAA
>5.12|1505239|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GTGGTTACTTGGGATACACCAAGGCGGCTAACAAA
>5.13|1505304|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GGAAATATATCTTCTCCTAGATCTCTGTACTTATTT
>5.14|1505370|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
ATATTAGGCTGTTTAAAAGATACCTTACAGTTAAAT
>5.15|1505436|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GCTGCAGAAAGAAAAAAGTGAGATGGAAGAAAAAAA
>5.16|1505502|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TATATACGTAAATAATTTAAGTGGAACAACAACATC
>5.17|1505568|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
CAACAACTTTCTCATGCAGGGGCCATATCAAAAGA
>5.18|1505633|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
AAAAGAAAATGAAAATAAAGTTCCAAGTGCAACCAT
>5.19|1505699|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
CTTCCACGCACTATGTAACACATTTTTGCTTTAGAG
>5.20|1505765|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
CATAACCATAGATCAGTGCAATAAATTGTTTTTTAC
>5.21|1505831|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTGCCTTATTAGCGAATACAATAGAATTAGAAATTA
>5.22|1505897|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
ATGGCTTTTGTTGCTGCTATGTGTGCAGGAGGTAC
>5.23|1505962|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTGAGAAGGAGTATAAAATTGCTAATAAGCAGATGA
>5.24|1506028|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GTATAGATACTACATGCATTAAGCATATAGATGTATT
>5.25|1506095|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TTTGACAGCAACAAGAGAAAGAATTTCACATATATT
>5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
AAATACATTTTATAAATTATTAAAAGAATATGAGG
>5.27|1506226|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GAAGCTATAGAAGAATTAAAGGATCTATAAGAGAAA
>5.28|1506292|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GAGGTATTTAAATTGTTAAAAGGTATAGATATATA
>5.29|1506357|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
ATCAACTCCTAAAATATTCATAAATTTTATACCTCC
>5.30|1506423|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
AAGGCGGATCCACAAATATTAAATCAGCCTCTTTCA
>5.31|1506489|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TATTTGTTATTGGAGTGTATGTAGCAACAAAGACAA
>5.32|1506555|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
GTATGATAGTGTGACAGGTGCTATTATATTAGACAC
>5.33|1506621|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR
TAACGGAAAAGGATGGGAGCACGTAAGTATAACACA

CRISPR arrays and Neighbor proteins around NC_022592_5

CRISPR arrays

The CRISPR arrays of NC_022592_5

>merge|NC_022592|5|1504480-1506686|CRISPRCasFinder,CRT,PILER-CR
AATTAGATACATCTCATGTTAAGGTTCAACAGTAGCTAATGATCAAATATTAACATTCCAATTACTATTTAAATACATCCTATGTTAAGGTTCAACAGGTGGTTATTTTCAAAATAGTTATCAAGCCACACCGATTTAAATACATCTTATGTTGAGGTTCAACTATATCAACTCTCCCCACTTTTGGGGAACGTACTCTATTTAAATACATCTTATGTTGAGGTTCAACGATGATTATAAAGTATGTTTGCTAACAGCTATAGCGTATTTAAATACATCTTATGTTGAGGTTCAACATTTGTACTTGGCTCTGCTATCTTGAATATTAATTTAATTTAAATACATCTTATGTTGAGGTTCAACTAATTATATATATTCTGATTGGGTTTATATAAATTCATTTAAATACATCTTATGTTGAGGTTCAACAAGAGTTGATACTTTACTTATAGATTACTTAGGTGCATTTAAATACATCTTATGTTGAGGTTCAACGGGCATTAAATATAAAAAGAAATATATTCCATGAATATTTAAATACATCTTATGTTGAGGTTCAACTCTATTACCTTAAGAAAATTAAGTCCACTAGCATTAATTTAAATACATCTTATGTTGAGGTTCAACCTATCCCAGCAATTAATATCTCTATTAATATCTCTCAATTTAAATACATCTTATGTTGAGGTTCAACATTGCTCACCCATTTTAAATAGTAATTCCCAAAAAATTTAAATACATCTTATGTTGAGGTTCAACGTGGTTACTTGGGATACACCAAGGCGGCTAACAAAATTTAAATACATCTTATGTTGAGGTTCAACGGAAATATATCTTCTCCTAGATCTCTGTACTTATTTATTTAAATACATCTTATGTTGAGGTTCAACATATTAGGCTGTTTAAAAGATACCTTACAGTTAAATATTTAAATACATCTTATGTTGAGGTTCAACGCTGCAGAAAGAAAAAAGTGAGATGGAAGAAAAAAAATTTAAATACATCTTATGTTGAGGTTCAACTATATACGTAAATAATTTAAGTGGAACAACAACATCATTTAAATACATCTTATGTTGAGGTTCAACCAACAACTTTCTCATGCAGGGGCCATATCAAAAGAATTTAAATACATCTTATGTTGAGGTTCAACAAAAGAAAATGAAAATAAAGTTCCAAGTGCAACCATATTTAAATACATCTTATGTTGAGGTTCAACCTTCCACGCACTATGTAACACATTTTTGCTTTAGAGATTTAAATACATCTTATGTTGAGGTTCAACCATAACCATAGATCAGTGCAATAAATTGTTTTTTACATTTAAATACATCTTATGTTGAGGTTCAACTTGCCTTATTAGCGAATACAATAGAATTAGAAATTAATTTAAATACATCTTATGTTGAGGTTCAACATGGCTTTTGTTGCTGCTATGTGTGCAGGAGGTACATTTAAATACATCTTATGTTGAGGTTCAACTTGAGAAGGAGTATAAAATTGCTAATAAGCAGATGAATTTAAATACATCTTATGTTGAGGTTCAACGTATAGATACTACATGCATTAAGCATATAGATGTATTATTTAAATACATCTTATGTTGAGGTTCAACTTTGACAGCAACAAGAGAAAGAATTTCACATATATTATTTAAATACATCTTATGTTGAGGTTCAACAAATACATTTTATAAATTATTAAAAGAATATGAGGATTTAAATACATCTTATGTTGAGGTTCAACGAAGCTATAGAAGAATTAAAGGATCTATAAGAGAAAATTTAAATACATCTTATGTTGAGGTTCAACGAGGTATTTAAATTGTTAAAAGGTATAGATATATAATTTAAATACATCTTATGTTGAGGTTCAACATCAACTCCTAAAATATTCATAAATTTTATACCTCCATTTAAATACATCTTATGTTGAGGTTCAACAAGGCGGATCCACAAATATTAAATCAGCCTCTTTCAATTTAAATACATCTTATGTTGAGGTTCAACTATTTGTTATTGGAGTGTATGTAGCAACAAAGACAAATTTAAATACATCTTATGTTGAGGTTCAACGTATGATAGTGTGACAGGTGCTATTATATTAGACACATTTAAATACATCTTATGTTGAGGTTCAACTAACGGAAAAGGATGGGAGCACGTAAGTATAACACAATTTAAATACATCTTATGTTGAGGTTCAAC

>NC_022592|5|4|1504480-1506686|CRISPRCasFinder
AATTAGATACATCTCATGTTAAGGTTCAAC	AGTAGCTAATGATCAAATATTAACATTCCAATTACT
ATTTAAATACATCCTATGTTAAGGTTCAAC	AGGTGGTTATTTTCAAAATAGTTATCAAGCCACACCG
ATTTAAATACATCTTATGTTGAGGTTCAAC	TATATCAACTCTCCCCACTTTTGGGGAACGTACTCT
ATTTAAATACATCTTATGTTGAGGTTCAAC	GATGATTATAAAGTATGTTTGCTAACAGCTATAGCGT
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATTTGTACTTGGCTCTGCTATCTTGAATATTAATTTA
ATTTAAATACATCTTATGTTGAGGTTCAAC	TAATTATATATATTCTGATTGGGTTTATATAAATTC
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAGAGTTGATACTTTACTTATAGATTACTTAGGTGC
ATTTAAATACATCTTATGTTGAGGTTCAAC	GGGCATTAAATATAAAAAGAAATATATTCCATGAAT
ATTTAAATACATCTTATGTTGAGGTTCAAC	TCTATTACCTTAAGAAAATTAAGTCCACTAGCATTA
ATTTAAATACATCTTATGTTGAGGTTCAAC	CTATCCCAGCAATTAATATCTCTATTAATATCTCTCA
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATTGCTCACCCATTTTAAATAGTAATTCCCAAAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GTGGTTACTTGGGATACACCAAGGCGGCTAACAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GGAAATATATCTTCTCCTAGATCTCTGTACTTATTT
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATATTAGGCTGTTTAAAAGATACCTTACAGTTAAAT
ATTTAAATACATCTTATGTTGAGGTTCAAC	GCTGCAGAAAGAAAAAAGTGAGATGGAAGAAAAAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	TATATACGTAAATAATTTAAGTGGAACAACAACATC
ATTTAAATACATCTTATGTTGAGGTTCAAC	CAACAACTTTCTCATGCAGGGGCCATATCAAAAGA
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAAAGAAAATGAAAATAAAGTTCCAAGTGCAACCAT
ATTTAAATACATCTTATGTTGAGGTTCAAC	CTTCCACGCACTATGTAACACATTTTTGCTTTAGAG
ATTTAAATACATCTTATGTTGAGGTTCAAC	CATAACCATAGATCAGTGCAATAAATTGTTTTTTAC
ATTTAAATACATCTTATGTTGAGGTTCAAC	TTGCCTTATTAGCGAATACAATAGAATTAGAAATTA
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATGGCTTTTGTTGCTGCTATGTGTGCAGGAGGTAC
ATTTAAATACATCTTATGTTGAGGTTCAAC	TTGAGAAGGAGTATAAAATTGCTAATAAGCAGATGA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GTATAGATACTACATGCATTAAGCATATAGATGTATT
ATTTAAATACATCTTATGTTGAGGTTCAAC	TTTGACAGCAACAAGAGAAAGAATTTCACATATATT
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAATACATTTTATAAATTATTAAAAGAATATGAGG
ATTTAAATACATCTTATGTTGAGGTTCAAC	GAAGCTATAGAAGAATTAAAGGATCTATAAGAGAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GAGGTATTTAAATTGTTAAAAGGTATAGATATATA
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATCAACTCCTAAAATATTCATAAATTTTATACCTCC
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAGGCGGATCCACAAATATTAAATCAGCCTCTTTCA
ATTTAAATACATCTTATGTTGAGGTTCAAC	TATTTGTTATTGGAGTGTATGTAGCAACAAAGACAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GTATGATAGTGTGACAGGTGCTATTATATTAGACAC
ATTTAAATACATCTTATGTTGAGGTTCAAC	TAACGGAAAAGGATGGGAGCACGTAAGTATAACACA
ATTTAAATACATCTTATGTTGAGGTTCAAC

>NC_022592|5|3|1504480-1506686|CRT
AATTAGATACATCTCATGTTAAGGTTCAAC	AGTAGCTAATGATCAAATATTAACATTCCAATTACT
ATTTAAATACATCCTATGTTAAGGTTCAAC	AGGTGGTTATTTTCAAAATAGTTATCAAGCCACACCG
ATTTAAATACATCTTATGTTGAGGTTCAAC	TATATCAACTCTCCCCACTTTTGGGGAACGTACTCT
ATTTAAATACATCTTATGTTGAGGTTCAAC	GATGATTATAAAGTATGTTTGCTAACAGCTATAGCGT
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATTTGTACTTGGCTCTGCTATCTTGAATATTAATTTA
ATTTAAATACATCTTATGTTGAGGTTCAAC	TAATTATATATATTCTGATTGGGTTTATATAAATTC
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAGAGTTGATACTTTACTTATAGATTACTTAGGTGC
ATTTAAATACATCTTATGTTGAGGTTCAAC	GGGCATTAAATATAAAAAGAAATATATTCCATGAAT
ATTTAAATACATCTTATGTTGAGGTTCAAC	TCTATTACCTTAAGAAAATTAAGTCCACTAGCATTA
ATTTAAATACATCTTATGTTGAGGTTCAAC	CTATCCCAGCAATTAATATCTCTATTAATATCTCTCA
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATTGCTCACCCATTTTAAATAGTAATTCCCAAAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GTGGTTACTTGGGATACACCAAGGCGGCTAACAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GGAAATATATCTTCTCCTAGATCTCTGTACTTATTT
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATATTAGGCTGTTTAAAAGATACCTTACAGTTAAAT
ATTTAAATACATCTTATGTTGAGGTTCAAC	GCTGCAGAAAGAAAAAAGTGAGATGGAAGAAAAAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	TATATACGTAAATAATTTAAGTGGAACAACAACATC
ATTTAAATACATCTTATGTTGAGGTTCAAC	CAACAACTTTCTCATGCAGGGGCCATATCAAAAGA
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAAAGAAAATGAAAATAAAGTTCCAAGTGCAACCAT
ATTTAAATACATCTTATGTTGAGGTTCAAC	CTTCCACGCACTATGTAACACATTTTTGCTTTAGAG
ATTTAAATACATCTTATGTTGAGGTTCAAC	CATAACCATAGATCAGTGCAATAAATTGTTTTTTAC
ATTTAAATACATCTTATGTTGAGGTTCAAC	TTGCCTTATTAGCGAATACAATAGAATTAGAAATTA
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATGGCTTTTGTTGCTGCTATGTGTGCAGGAGGTAC
ATTTAAATACATCTTATGTTGAGGTTCAAC	TTGAGAAGGAGTATAAAATTGCTAATAAGCAGATGA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GTATAGATACTACATGCATTAAGCATATAGATGTATT
ATTTAAATACATCTTATGTTGAGGTTCAAC	TTTGACAGCAACAAGAGAAAGAATTTCACATATATT
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAATACATTTTATAAATTATTAAAAGAATATGAGG
ATTTAAATACATCTTATGTTGAGGTTCAAC	GAAGCTATAGAAGAATTAAAGGATCTATAAGAGAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GAGGTATTTAAATTGTTAAAAGGTATAGATATATA
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATCAACTCCTAAAATATTCATAAATTTTATACCTCC
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAGGCGGATCCACAAATATTAAATCAGCCTCTTTCA
ATTTAAATACATCTTATGTTGAGGTTCAAC	TATTTGTTATTGGAGTGTATGTAGCAACAAAGACAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GTATGATAGTGTGACAGGTGCTATTATATTAGACAC
ATTTAAATACATCTTATGTTGAGGTTCAAC	TAACGGAAAAGGATGGGAGCACGTAAGTATAACACA
ATTTAAATACATCTTATGTTGAGGTTCAAC

>NC_022592|5|4|1504613-1506686|PILER-CR
ATTTAAATACATCTTATGTTGAGGTTCAAC	TATATCAACTCTCCCCACTTTTGGGGAACGTACTCT
ATTTAAATACATCTTATGTTGAGGTTCAAC	GATGATTATAAAGTATGTTTGCTAACAGCTATAGCGT
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATTTGTACTTGGCTCTGCTATCTTGAATATTAATTTA
ATTTAAATACATCTTATGTTGAGGTTCAAC	TAATTATATATATTCTGATTGGGTTTATATAAATTC
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAGAGTTGATACTTTACTTATAGATTACTTAGGTGC
ATTTAAATACATCTTATGTTGAGGTTCAAC	GGGCATTAAATATAAAAAGAAATATATTCCATGAAT
ATTTAAATACATCTTATGTTGAGGTTCAAC	TCTATTACCTTAAGAAAATTAAGTCCACTAGCATTA
ATTTAAATACATCTTATGTTGAGGTTCAAC	CTATCCCAGCAATTAATATCTCTATTAATATCTCTCA
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATTGCTCACCCATTTTAAATAGTAATTCCCAAAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GTGGTTACTTGGGATACACCAAGGCGGCTAACAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GGAAATATATCTTCTCCTAGATCTCTGTACTTATTT
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATATTAGGCTGTTTAAAAGATACCTTACAGTTAAAT
ATTTAAATACATCTTATGTTGAGGTTCAAC	GCTGCAGAAAGAAAAAAGTGAGATGGAAGAAAAAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	TATATACGTAAATAATTTAAGTGGAACAACAACATC
ATTTAAATACATCTTATGTTGAGGTTCAAC	CAACAACTTTCTCATGCAGGGGCCATATCAAAAGA
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAAAGAAAATGAAAATAAAGTTCCAAGTGCAACCAT
ATTTAAATACATCTTATGTTGAGGTTCAAC	CTTCCACGCACTATGTAACACATTTTTGCTTTAGAG
ATTTAAATACATCTTATGTTGAGGTTCAAC	CATAACCATAGATCAGTGCAATAAATTGTTTTTTAC
ATTTAAATACATCTTATGTTGAGGTTCAAC	TTGCCTTATTAGCGAATACAATAGAATTAGAAATTA
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATGGCTTTTGTTGCTGCTATGTGTGCAGGAGGTAC
ATTTAAATACATCTTATGTTGAGGTTCAAC	TTGAGAAGGAGTATAAAATTGCTAATAAGCAGATGA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GTATAGATACTACATGCATTAAGCATATAGATGTATT
ATTTAAATACATCTTATGTTGAGGTTCAAC	TTTGACAGCAACAAGAGAAAGAATTTCACATATATT
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAATACATTTTATAAATTATTAAAAGAATATGAGG
ATTTAAATACATCTTATGTTGAGGTTCAAC	GAAGCTATAGAAGAATTAAAGGATCTATAAGAGAAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GAGGTATTTAAATTGTTAAAAGGTATAGATATATA
ATTTAAATACATCTTATGTTGAGGTTCAAC	ATCAACTCCTAAAATATTCATAAATTTTATACCTCC
ATTTAAATACATCTTATGTTGAGGTTCAAC	AAGGCGGATCCACAAATATTAAATCAGCCTCTTTCA
ATTTAAATACATCTTATGTTGAGGTTCAAC	TATTTGTTATTGGAGTGTATGTAGCAACAAAGACAA
ATTTAAATACATCTTATGTTGAGGTTCAAC	GTATGATAGTGTGACAGGTGCTATTATATTAGACAC
ATTTAAATACATCTTATGTTGAGGTTCAAC	TAACGGAAAAGGATGGGAGCACGTAAGTATAACACA
ATTTAAATACATCTTATGTTGAGGTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl|CDD|188234
NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl|CDD|187853
NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl|CDD|350688
NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_022592.1|WP_013240126.1|1509131_1510010_-|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
NC_022592.1|WP_023162236.1|1507906_1508449_-|nitroreductase-family-protein	unknown	unknown	gnl|CDD|380316
NC_022592.1|WP_029169904.1|1507372_1507879_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|379082
NC_022592.1|WP_029169905.1|1511755_1512193_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl|CDD|366863
NC_022592.1|WP_023162232.1|1503835_1504351_-|hypothetical-protein	unknown	unknown	unknown
NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_022592.1|WP_013240129.1|1512633_1513203_+|energy-coupling-factor-transporter-S-component-ThiW	unknown	unknown	gnl|CDD|370540
NC_022592.1|WP_013240131.1|1514025_1515441_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197716
NC_022592.1|WP_013240127.1|1510165_1511620_+|MFS-transporter	unknown	unknown	gnl|CDD|129794
NC_022592.1|WP_013240125.1|1508652_1509117_+|DUF1648-domain-containing-protein	unknown	unknown	gnl|CDD|377929
NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl|CDD|131641
NC_022592.1|WP_029169906.1|1513180_1513978_+|hydroxyethylthiazole-kinase	unknown	unknown	gnl|CDD|238575
NC_022592.1|WP_023162234.1|1506959_1507358_+|polyketide-cyclase/dehydrase	unknown	unknown	gnl|CDD|176866
NC_022592.1|WP_023162231.1|1503044_1503806_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	7.7e-45	147.7	9.7
NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	5.4e-30	99.5	0.3
NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein	cas6	cd09652_cas6_CAS-I:CAS-III	6.8e-12	40.9	3.1
NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	2e-175	579.7	63.4
NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	4.7e-125	411.7	10.9
NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	1.4e-37	124.2	7.8
NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	1.6e-50	166.6	5.5
NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.1e-24	81.2	0.7

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.24266e-48
NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein	gnl|CDD|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	9.63104e-18
NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl|CDD|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	5.06183e-148
NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	2.30789e-29
NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	5.26285e-22
NC_022592.1|WP_013240126.1|1509131_1510010_-|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	9.46729e-31
NC_022592.1|WP_023162236.1|1507906_1508449_-|nitroreductase-family-protein	gnl|CDD|380316	cd02139, nitroreductase, nitroreductase family protein. A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.	7.342e-71
NC_022592.1|WP_029169904.1|1507372_1507879_-|AAA-family-ATPase	gnl|CDD|379082	pfam13238, AAA_18, AAA domain.	6.07121e-15
NC_022592.1|WP_029169905.1|1511755_1512193_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.11944e-11
NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4	gnl|CDD|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.87503e-50
NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	4.92532e-07
NC_022592.1|WP_013240129.1|1512633_1513203_+|energy-coupling-factor-transporter-S-component-ThiW	gnl|CDD|370540	pfam09512, ThiW, Thiamine-precursor transporter protein (ThiW). Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.	6.31826e-48
NC_022592.1|WP_013240131.1|1514025_1515441_-|MerR-family-transcriptional-regulator	gnl|CDD|197716	smart00422, HTH_MERR, helix_turn_helix, mercury resistance.	1.60945e-19
NC_022592.1|WP_013240127.1|1510165_1511620_+|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.51889e-61
NC_022592.1|WP_013240125.1|1508652_1509117_+|DUF1648-domain-containing-protein	gnl|CDD|377929	pfam07853, DUF1648, Protein of unknown function (DUF1648). Members of this family are hypothetical proteins expressed by either bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues.	0.000118441
NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5	gnl|CDD|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.18725e-44
NC_022592.1|WP_029169906.1|1513180_1513978_+|hydroxyethylthiazole-kinase	gnl|CDD|238575	cd01170, THZ_kinase, 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine and 1-deoxy-D-xylulose-5-phosphate.	8.54678e-94
NC_022592.1|WP_023162234.1|1506959_1507358_+|polyketide-cyclase/dehydrase	gnl|CDD|176866	cd07824, SRPBCC_6, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	5.90696e-05
NC_022592.1|WP_023162231.1|1503044_1503806_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.0633e-13

Protein sequences

>NC_022592.1|WP_023162232.1|1503835_1504351_-|hypothetical-protein
MIKKLHGYLINLSIFKFILITSIIPFFISYIASLVIKNYVRQFPNDILKVNNSLITNVSFTINGIFIAPLVETFIFVIIISIFLYYSYSQTIQIIAVIVAAICFGIPHFFNTNDMIWGLYWAIQAGIKGLILGYAFMVYFFKSKRIDVAGFVVFLIHSINNLLGIIISLIF
>NC_022592.1|WP_023162231.1|1503044_1503806_-|CPBP-family-intramembrane-metalloprotease
MVVDGLVNAFINITLFIIVIMLVKKIESIRNKDYTPVYWISLKKHDIKLFVIGIIVALLYKLAVGSIGIIGGTMELIVNGPGMAKFIIFTLASSFGFLGVALFEEGLYRGYVMQVAFRKLPKVLAIVLQALVFGLVHYSNYSKQPHTWIRIIDAILIGVIFGVIVIKTKSLMFTVGTHLFYDATEQMLFLDNPYKFTRFICFQNTNYLSSSLFYTEFIELSMLSILTVVLIFLFRKNLFYDKSFSTNLRSKGA
>NC_022592.1|WP_023162228.1|1498779_1499490_-|CRISPR-associated-protein
MEINQINIKVYILENISIEQALEDLSKLMDKSFYENEDMKNFHEENMMKNYCFNSLYPLDVKTKMYKEGGIYNFQLRCIGSKLKNHFLKFLSNEYTSKIKVLVCQSKNIPKRPMDRIYSITPVIVKMPGSEKTEYWRNEYTEEEFFEYIRTTSIKKYEVLTGEAVDKNLKLFNYAKIDNKKPIAASFKDKRILGDKVTLNLETNSDAQNIAYMLLGTGLADMSPRGYGFVNYQYIK
>NC_022592.1|WP_023162227.1|1497006_1498761_-|hypothetical-protein
MINEICKIFSSEYGKKGDALIVDNYTLSPGDYVEFTLEDSGDRVEIFSVDKKTDKSQDDYRKFAKMDCISGLISMNKPVDPTKVIHSNNMYTFYVKKENLDPSKGKLNVEIIDKYYDILKNPKDKYKNKKKSLELYLKFEKEQGKPDGELIDKIRDWIKQNIYKIASRKSLDKTYLKLFYNTDSKNYERESQRYIIPNIYNSTDYNVKIGDKVYGLPDFNIGLNSKKPYLENKTRKSKLPVLVDSSTISMEKKLFDYFMNYAQEKKNYIYAGSDIDAVDYKENKKDDFKGYFLRINKGKEAEIADYDTITEYRYKLKRSIEVLPIINGGAGKDFELFLGVLNNLGEVKSRISEVFFNKYLENNFFTEAKSINLNDARVKECLLKYRYGLYTWFYKGEDFLASTFWNSMTLYLLCNSINQGNINKAVNQFNLRHAVLYYFNNEKGGKSMDAVVKSVRKSIDEKINIKEDPEYKVEAENDEEYYFCIGQLLKYFYSLNKSGNKSYSFINPFLNAKSSEFIKEKLRKLFIKYDYAIQSSFRFNNMYYMVSSYNTEGKVDQDIIIAGFLCPNLIYKKSEKENQNEEAN
>NC_022592.1|WP_023162226.1|1496076_1497006_-|type-I-CRISPR-associated-protein-Cas7
MNRVYGVIGIKSIMANWNADFSGYPKTISDGSIFGSDKALKYSIKKYWEDRGEKILYIKSFKTDKGKIRPRSLEERYNQVFDTTLTKKDESTVILKNLFSALDVKSFGATFAEEGNNISLTGAVQIGQGFNVYEDSNAEEQQILSPFRSDKKPKEGKEAEEANQSTLGTKIVSDEAHYMYPFYINPTSYRDYVDMKVTEGYTEEDYKKFKEGALLGATALNTNAKAGCENEFALFVETDEETYLPNLTQFMKFEKRKDKEILTLNLEEILQGIEDDIKKIEIYYNDYKLKLNNIPKGAVLFNIFTRKEV
>NC_022592.1|WP_023162225.1|1495326_1496073_-|type-I-B-CRISPR-associated-protein-Cas5
MKVVRFKLSGKTAFFKKPDVNTYCCFTYGNIHKIALLGIMGSVLGFRGYNEQSRNFKKNVYPEFYEKLKNAKVAVVTINKHGYISKKVQEFNNSVGYASRESGGNLIVKQQWLQNPKWMIYVKIDNITDEFSNMIRKNKAKFIPYLGTNDHFADITKVSELEVHKEDDVDKVDSIFETKYFKIDKYQDEEEDTDTAWKYTEYLPVALDKDLNQYQFSDFTETNMAVDSFNESVDVYRDEELDKNLYFF
>NC_022592.1|WP_023162224.1|1492746_1495314_-|CRISPR-associated-helicase/endonuclease-Cas3
MYFDDVELFNPEFFISNLDNMYAHRDRTDKTRREKLTDHINLTYKYFEFICSEKDLDNVFNNLQKDILEDRCEDVICLWKEMLANTIYMHDIGKINPAFQYANMLNKLYKDNSAGEKNHSLLGSYIYVSYFNGRINKIKKRYDRYYLKYFMYLNSYIISRHHGFLGSIEGYGEKLKNFSENYKKETYYPDLNMDVLGERVIYKSFCNSQEYIKDCFLANSKLDFTLYIYSKLLFSILTAADYYATSQFMNGEKVDDMGIMDDELKKRFSRDVEDYDILKSIRSYEKNPVIDGKYSNINQLRSKITLESEKSYLKNRNKNIYYLEAPTGAGKTITSINLVRHMLNSNEKINKLFYVFPFNTLVEQTESAFIKIFKNDSKIRESISVINSITPIKTVDKDYEVESDLDSGRKTDYEKSLLNRIFINYPFVITTHVNLFNSLFGTSRKEVFPLINLCNSIIILDEIQSYKNEIWKEIINFLDSYSELLNIKVIIMSATLPRLNKLVEGNSNDFIYLIEDRNKYFKNPYFKSRVKFEMLDLGDEEEQFEKLSRDIQAESRDNGKILIEFIFKKRADRFFDYMNKNFENKYGHEIKIMTADDNKIDRGKIVKMARDKEKKIILIATQIVEAGIDIDMDLGYKNISILDAEEQFMGRVNRSCLKKGRVKFFKIDDCRVIYKGDVRREKELTLIQSEIQKLLGEKDFEKYYEKVIEKIKLKKQESNDHGYEAFTKKLDSMNFKAVQDYMKLIDEDQNKYTVFISREIKLGNNDVIYGDDIWKEYKDVLMDKSMGYAEKKVKLSKITPNLGYFIYKVKEIPTEYSDMLGDIYYISDGEKYIRDGRFNQEIFIGEAPDEANLFM
>NC_022592.1|WP_023162223.1|1492233_1492728_-|CRISPR-associated-protein-Cas4
MKINGTLINYYFHCKRQFWLHANRINMEYTNEDVKIGKVIHELKAEGNKNAEICIDNVKIDKITKDYLVEIKKSDADVEAVKWQVLFYLSILKNKGIYREGKIEFQEKNKQDKKIIYVSLTEENEMKLKELNLEMEKLLEKDMPPKVGKVKGCKKCAYYEYCYI
>NC_022592.1|WP_023162222.1|1491211_1492216_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MASGTKYLMSMGELKRKDNSVLFHNEKGNFYLPIESTREIYCMNEITVNSKFLDFAAKAGIVIHFFNYYGYYSGSFYPKESLVSGKVTIKQVEAFLNNRNYIAKSFVWGIGENICQILYHYYRHDKKEVEPTINWIKEKVPEYLEDGNLGIKQVLRVEGEIWQRFYENFKYILPEDFIMNKRVKRPPDNPINALISFGNSILYSKTVSQIYNTHLNQTISYLHEPSEGRFSLSLDLSEVFKPVIVYRTIFELVNTKQIQVNKHFDKKYNYCLLNEEGKKIFVQAIEQRFESVFDHKKLKRKISYKTAIRLDGYKLIKYVVEGEEFKPFSLKNMM
>NC_022592.1|WP_023162221.1|1490910_1491195_-|CRISPR-associated-endonuclease-Cas2
MGKNFNFNYAFVFYDVNEKRVNKVFKVCKKYFHHHQNSVFRGAITTSKMIKLKSELNKIIKDKDFVTIIKLMNDSCFEEDTLGINENNTEDLIL
>NC_022592.1|WP_023162234.1|1506959_1507358_+|polyketide-cyclase/dehydrase
MKESTITTTFKSDIKKVWDVVTNNNKYEWRSDLSKIDVSEDGNSFTEYTKNNFPTKFNITLKKPYERYEFDMTNKNMKGHWIGTFSPANNGTQIEFAEKVSVNNPIMNLFAGLYLKKQQSLYIADLKKELGE
>NC_022592.1|WP_029169904.1|1507372_1507879_-|AAA-family-ATPase
MKNLIFINGTMGVGKTATSKELQKLLPKCVFLDGDWCWNMSPFIVTDETKSMVIDNITYMLNNFISCSEYENIIFCWVMHMQSILDDVLSRINKRGCKVYKFSLICSEKSLIERITKDIENGTRTEDVIDRSVPRLNNYLKMDTDKIDVDEISAKDAAEIIYKRVIAT
>NC_022592.1|WP_023162236.1|1507906_1508449_-|nitroreductase-family-protein
MIEEISTRRSIRKYIDREVENEKILQLIEGARLAPSGSNTQPWHFIVVKSESNRQKISQVCHNQKWMLSAPVFIACVADIRCRIDEKIAVSLDENSPEEELKQIIRDTSISVEHILLGADNLGLGTCWVGWFVQNEIRPILNIPDDKYVVGIVTLGYADEKPKPRPRKKLEEIIHYESWK
>NC_022592.1|WP_013240125.1|1508652_1509117_+|DUF1648-domain-containing-protein
MKIKKNKFDIMVNLLSLLCLVGTVVVLTILWKTIPAKIPGHYNAAGTIDKVTDKNSLIVLLLVGWIIFIGISIVEKFPQIWNTGIQVTEQNKEKVYRILKNMIGTVKLLIASVFSYLTLQSTTGKNLSPLFLPIFLILLFGSIVFFIFQLVKEK
>NC_022592.1|WP_013240126.1|1509131_1510010_-|AraC-family-transcriptional-regulator
MNKSKINYYYKDMPDKNFFVDIFEVKVNKLGATFEENWHEHLQFFYFIQGSALIRCNYKSIHVKAGDFIIVNSNELHYCESLCDNLIYYIIRVDLSFLFSSQMDSCQTKFMVPLAKNLILFKNLVRNDKDILNCADKIIEEYFSKRLGYELAVKAYIYEVIVLLLRKYVEKVLTAGQFNCRVDNLNRLKNIFLYINENFTEKITLDEISEMAHISKEHFCRTFKQITGRSLTNYINNLRIQKADSLLQETDLNITEIALNCGFSDVNYFSRIYKKVKNVSPLNFRKNFCSNL
>NC_022592.1|WP_013240127.1|1510165_1511620_+|MFS-transporter
MEYKNKYGILLVVISMTFMSCLVSNIVNVALPVMSRKLSVPMVSIEWVVASYIISICSTILVFGRLGDVIGKMKVFKFGMVVFTIASFTCGISTSFTELIIFRIIQGIGASAYMANNQGIITQVFPRNERGKALGILASSVALGTLIGSPAGGFITYYLSWNYIFFVNVPIGVIAFIAALKVLPHSKTQNKEINSELDVKGSTFIFLSMVLLFGSLIQGQKVGYNNPIIITIFIVSILFVVVFIVLENKIEKPLIQMKIFKNNVFSLSLFCAFISFVCLNASIIIIPFYLQDAMKLNSSITGLIMMIQPLVMAVISPFSGNLSDKIGSKLLSFLGLLLMSISFIFLSFLNQYSSITKIIIYIVVLGLGQSLFQPSNNSLIMSTVPKNELGIAGSVNSLVRNLGQIIGIILSTSLLYSFMSIKIGYRITDYVTGRDDIFVYGMKYVYIVLTIVCAFGALLTAFRMHNKKSIQTNQSPADIHGKNF
>NC_022592.1|WP_029169905.1|1511755_1512193_+|GNAT-family-N-acetyltransferase
MVTITRITYDDLNDLSNLYEELLGKKTNLQKFKDKFTLINSNKNYILIGAKDSDNTLVGSLLGIICQDLGGECKPFMVVENVIVKNNCRRMGIGKTLMTFIESFARKKDCYFTMLVSAFKRKDAHKFYESIGYNNDVVKGFKKYL
>NC_022592.1|WP_013240129.1|1512633_1513203_+|energy-coupling-factor-transporter-S-component-ThiW
MERNSKLLKKLMLAMMVAMGVVISPILRIEGMCPMSSVINITCAVFFGPWYALLCAVCIGIIRMFLMGIPPLALTGAVFGAFLAGFLYRISKNTLIFAVLGEVIGTGIIGAVVSSPIMTYFWGKKGLSLMFYIPLFFTATIIGGTIAFIFLGTLSKNGMLIKIQKDLGVKVYDKSTDTDKQPIANKTQC
>NC_022592.1|WP_029169906.1|1513180_1513978_+|hydroxyethylthiazole-kinase
MQIKRNVKIKKPLIHYITNPISINDCANAMLAIGAKPIMAEHPLEVSEITSASNALGVNLGNITDVRMKSMLISGKTAFKERIPQVIDLVGVGCSKLRFNYAKKFISQCHPDVIKGNLSEIRALCGIESNAKGIDAGECDKITEDNFDENIEIVKKLSLRTNSVIAATGAVDVITNGSKTYLIKNGCEMLSMVTGTGCMVTALIASYISSLDIFGATILAVSLMGICGELSHHVTGIGSFRTNLIDNLFTISDNTIINKIKCELK
>NC_022592.1|WP_013240131.1|1514025_1515441_-|MerR-family-transcriptional-regulator
MKISEVMEITSLTKKAINYYEENGLISPSVNKENNYRDYTKKDIEKLKQISVLRNFDIPVKKIKEILVNPKEMEKIFTEHLNKIKAQILNMERSKEIFQLCINDISFPSSDIGKVTDDMMLLKRSLDMSEREKEGYMKRELIRIFPGFFGRYICLKYSNYLDEPIDSREKENAWIHLVKTLDDSHELKVNKEILENMELDEIDWNLLEEIIKNRDKDFYSMNEEDIQNYVDNLYDAELTETDLKLLEQFVSYTSSKDNIKYMNDLLKLIDEDLKVLSSKYKKFQENLSSVNCKMKKVYTENSKVSANEIENNMGIITLPEMTFVGCEYKKIIPPGKTPKLIENFRKRIDEISNVINPGDIYTINGIDSLPQYEKPKTLIHKLSFSFIVGVQVSKAEQIPKDMQVFTIPSHKHAWYTTSESKNLKSFMKNEIPLITFISQAHKIVEFPVLTLYSSDCKDTRESAVYNYMPVE

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022592_1	1.2|646251|16|NC_022592|PILER-CR	646251-646266	16	NC_022592.1	646322-646337	0	1.0

1. spacer 1.2|646251|16|NC_022592|PILER-CR matches to position: 646322-646337, mismatch: 0, identity: 1.0

tttctcctttcagtcg	CRISPR spacer
tttctcctttcagtcg	Protospacer
****************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP029456	Bacillus cereus strain FORC087 plasmid pFORC087.2, complete sequence	77180-77214	3	0.914
NC_022592_3	3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT	1489676-1489710	35	MK250016	Prevotella phage Lak-A1, complete genome	116442-116476	6	0.829
NC_022592_3	3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT	1489676-1489710	35	MK250019	Prevotella phage Lak-A2, complete genome	39568-39602	6	0.829
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP015353	Bacillus thuringiensis strain MYBT18246 plasmid p120510, complete sequence	64114-64148	6	0.829
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP015353	Bacillus thuringiensis strain MYBT18246 plasmid p120510, complete sequence	51909-51943	6	0.829
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NC_022877	Bacillus thuringiensis YBT-1518 plasmid pBMB0232, complete sequence	14520-14554	6	0.829
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP015356	Bacillus thuringiensis strain MYBT18246 plasmid p101287, complete sequence	57426-57460	6	0.829
NC_022592_3	3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT	1489676-1489710	35	MN698244	Pelagibacter phage HTVC106P, complete genome	13948-13982	7	0.8
NC_022592_4	4.22|1501328|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1501328-1501363	36	LN846931	Carnobacterium maltaromaticum strain LMA28 megaplasmid, complete genome	50135-50170	7	0.806
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP024657	Bacillus cereus strain MLY1 plasmid pMLY1.1, complete sequence	86822-86856	7	0.8
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP015253	Bacillus thuringiensis Bt18247 plasmid p113275, complete sequence	74478-74512	7	0.8
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP012100	Bacillus thuringiensis strain HS18-1 plasmid pHS18-1, complete sequence	32516-32550	7	0.8
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	KY593455	Yersinia phage fHe-Yen9-01, complete genome	19853-19887	7	0.8
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP040803	Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence	59822-59856	7	0.8
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NC_010576	Lactococcus phage 1706, complete genome	26850-26884	7	0.8
NC_022592_3	3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT	1489676-1489710	35	MF360958	Salicola phage SCTP-2, complete genome	138522-138556	8	0.771
NC_022592_3	3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT	1489676-1489710	35	NZ_CP024792	Nostoc flagelliforme CCNUN1 plasmid pNFSY07, complete sequence	299718-299752	8	0.771
NC_022592_4	4.25|1501525|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1501525-1501560	36	NZ_CP028161	Lactococcus lactis subsp. lactis strain 14B4 plasmid p14B4, complete sequence	39837-39872	8	0.778
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP015354	Bacillus thuringiensis strain MYBT18246 plasmid p120416, complete sequence	101863-101897	8	0.771
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP015354	Bacillus thuringiensis strain MYBT18246 plasmid p120416, complete sequence	39882-39916	8	0.771
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	CP016197	Bacillus thuringiensis serovar coreanensis strain ST7 plasmid pST7-3, complete sequence	29990-30024	8	0.771
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	CP016198	Bacillus thuringiensis serovar coreanensis strain ST7 plasmid pST7-4, complete sequence	672-706	8	0.771
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NZ_CP021437	Bacillus thuringiensis strain C15 plasmid pBMB240, complete sequence	9574-9608	8	0.771
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	MT074141	Bacteroides phage DAC22, complete genome	152119-152153	8	0.771
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	MT074146	Bacteroides phage SJC03, complete genome	139326-139360	8	0.771
NC_022592_5	5.29|1506357|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506357-1506392	36	MN693405	Marine virus AFVG_25M416, complete genome	30906-30941	8	0.778
NC_022592_5	5.29|1506357|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506357-1506392	36	MN693333	Marine virus AFVG_25M417, complete genome	30870-30905	8	0.778
NC_022592_5	5.29|1506357|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506357-1506392	36	MN693092	Marine virus AFVG_25M37, complete genome	29256-29291	8	0.778
NC_022592_3	3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT	1489676-1489710	35	AP013501	Uncultured Mediterranean phage uvMED DNA, complete genome, group G19, isolate: uvMED-CGR-U-MedDCM-OCT-S24-C60	24173-24207	9	0.743
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	NZ_CP046711	Nostoc sp. ATCC 53789 plasmid pNsp_h, complete sequence	37603-37639	9	0.757
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MT774402	CrAssphage cr7_1, complete genome	12772-12808	9	0.757
NC_022592_5	5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1506161-1506195	35	NC_022875	Bacillus thuringiensis YBT-1518 plasmid pBMB0230, complete sequence	38171-38205	9	0.743
NC_022592_4	4.1|1499938|36|NC_022592|CRISPRCasFinder,CRT	1499938-1499973	36	NZ_CP035175	Lactobacillus plantarum strain SRCM103426 plasmid unnamed1	180390-180425	10	0.722
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	NZ_CP011154	Bacillus cereus strain CMCC P0011 plasmid pRML05, complete sequence	192263-192299	10	0.73
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	NZ_CP011152	Bacillus cereus strain CMCC P0021 plasmid pRML04, complete sequence	354616-354652	10	0.73
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MT074142	Bacteroides phage DAC23, complete genome	9760-9796	10	0.73
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MT074139	Bacteroides phage DAC19, complete genome	10923-10959	10	0.73
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	AP014321	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S33-C32, *** SEQUENCING IN PROGRESS ***	14548-14584	10	0.73
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MT074140	Bacteroides phage DAC20, complete genome	10923-10959	10	0.73
NC_022592_4	4.41|1502580|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1502580-1502615	36	NZ_CP020080	Vibrio campbellii strain 20130629003S01 plasmid pVCGX3, complete sequence	74283-74318	10	0.722
NC_022592_4	4.41|1502580|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1502580-1502615	36	NZ_CP019296	Vibrio campbellii strain LMB29 plasmid pLMB143, complete sequence	26511-26546	10	0.722
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MT074137	Bacteroides phage DAC16, complete genome	9380-9416	11	0.703
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MT074141	Bacteroides phage DAC22, complete genome	10924-10960	11	0.703
NC_022592_4	4.32|1501986|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1501986-1502021	36	NZ_CP012100	Bacillus thuringiensis strain HS18-1 plasmid pHS18-1, complete sequence	503189-503224	11	0.694
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	KM216423	Staphylococcus phage P108, complete genome	97272-97308	12	0.676
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MT786458	Staphylococcus phage vB_SauH_SAP1, complete genome	27760-27796	13	0.649
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MG557618	Staphylococcus phage HSA30, complete genome	116520-116556	13	0.649
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	KY779849	Staphylococcus phage qdsa002, complete genome	21780-21816	13	0.649
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MF001365	Staphylococcus phage SA3, partial genome	132814-132850	13	0.649
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MH159197	Staphylococcus phage VB_SavM_JYL01, complete genome	132652-132688	13	0.649
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MN304941	Staphylococcus phage vB_SauH_IME522, complete genome	20985-21021	13	0.649
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MK250904	Staphylococcus phage VB-SavM-JYL02, complete genome	131224-131260	13	0.649
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	MT554104	Staphylococcus phage ESa1, complete genome	18907-18943	13	0.649
NC_022592_4	4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR	1500532-1500568	37	NC_019448	Staphylococcus phage GH15, complete genome	17644-17680	13	0.649

1. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP029456 (Bacillus cereus strain FORC087 plasmid pFORC087.2, complete sequence) position: , mismatch: 3, identity: 0.914

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
aaatacattttataaaataataaaagaatatgaga	Protospacer
**************** ** **************.

2. spacer 3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT matches to MK250016 (Prevotella phage Lak-A1, complete genome) position: , mismatch: 6, identity: 0.829

aattaaatcttctatttctttatctg-tattgttta	CRISPR spacer
atttaaatctcctattactttatctgttgctgttt-	Protospacer
* ********.***** ********* *..***** 

3. spacer 3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT matches to MK250019 (Prevotella phage Lak-A2, complete genome) position: , mismatch: 6, identity: 0.829

aattaaatcttctatttctttatctg-tattgttta	CRISPR spacer
atttaaatctcctattactttatctgttgctgttt-	Protospacer
* ********.***** ********* *..***** 

4. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP015353 (Bacillus thuringiensis strain MYBT18246 plasmid p120510, complete sequence) position: , mismatch: 6, identity: 0.829

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttataaattagtaaaagaatatgagg	Protospacer
   * * ************ ***************

5. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP015353 (Bacillus thuringiensis strain MYBT18246 plasmid p120510, complete sequence) position: , mismatch: 6, identity: 0.829

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttataaattagtaaaagaatatgagg	Protospacer
   * * ************ ***************

6. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NC_022877 (Bacillus thuringiensis YBT-1518 plasmid pBMB0232, complete sequence) position: , mismatch: 6, identity: 0.829

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttataaattagtaaaagaatatgagg	Protospacer
   * * ************ ***************

7. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP015356 (Bacillus thuringiensis strain MYBT18246 plasmid p101287, complete sequence) position: , mismatch: 6, identity: 0.829

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttataaattagtaaaagaatatgagg	Protospacer
   * * ************ ***************

8. spacer 3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT matches to MN698244 (Pelagibacter phage HTVC106P, complete genome) position: , mismatch: 7, identity: 0.8

aattaaatcttctatttctttatctgtattgttta	CRISPR spacer
aattaaattttctttttctttatctgttaattttt	Protospacer
********.**** *************    *** 

9. spacer 4.22|1501328|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to LN846931 (Carnobacterium maltaromaticum strain LMA28 megaplasmid, complete genome) position: , mismatch: 7, identity: 0.806

ttaaataattagtataaaaatggaggaatgtataaa	CRISPR spacer
ttaaataattagtataaaaacggagggattaggata	Protospacer
********************.*****.**  . * *

10. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP024657 (Bacillus cereus strain MLY1 plasmid pMLY1.1, complete sequence) position: , mismatch: 7, identity: 0.8

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttataaattagtcaaagaatatgagg	Protospacer
   * * ************ * *************

11. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP015253 (Bacillus thuringiensis Bt18247 plasmid p113275, complete sequence) position: , mismatch: 7, identity: 0.8

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttataaattagtcaaagaatatgagg	Protospacer
   * * ************ * *************

12. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP012100 (Bacillus thuringiensis strain HS18-1 plasmid pHS18-1, complete sequence) position: , mismatch: 7, identity: 0.8

aaatacattttataaattattaaaa-gaatatgagg	CRISPR spacer
aaatgcattttatagattattaaaaggggtatgcc-	Protospacer
****.*********.********** *..****   

13. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to KY593455 (Yersinia phage fHe-Yen9-01, complete genome) position: , mismatch: 7, identity: 0.8

-aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
tcaatg-gttttctaaatttttaaaagaatatgacg	Protospacer
  ***. .**** ****** ************** *

14. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP040803 (Streptococcus salivarius strain LAB813 plasmid pSAL813, complete sequence) position: , mismatch: 7, identity: 0.8

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
aaaactaattaataaagtattaaaagaatatgaag	Protospacer
***  .* ** ***** ****************.*

15. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NC_010576 (Lactococcus phage 1706, complete genome) position: , mismatch: 7, identity: 0.8

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
agatctatatgataaattattaaaagaatataatg	Protospacer
*.** .** * ********************.* *

16. spacer 3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT matches to MF360958 (Salicola phage SCTP-2, complete genome) position: , mismatch: 8, identity: 0.771

aattaaatcttctatttctttatctgtattgttta	CRISPR spacer
aattaaatcttgtatttcattatctgctatttgaa	Protospacer
*********** ****** *******.  * *  *

17. spacer 3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024792 (Nostoc flagelliforme CCNUN1 plasmid pNFSY07, complete sequence) position: , mismatch: 8, identity: 0.771

aattaaatcttctatttctttatctgtattgttta------	CRISPR spacer
aattaaatcttctatttgtttgtct------tttaacagta	Protospacer
***************** ***.***      ****      

18. spacer 4.25|1501525|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP028161 (Lactococcus lactis subsp. lactis strain 14B4 plasmid p14B4, complete sequence) position: , mismatch: 8, identity: 0.778

tagaccacaattaaatgcaatgttagaatttgctcg	CRISPR spacer
gcgaccacaattaaaagcaatgctagaatatatccg	Protospacer
  ************* ******.****** *...**

19. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP015354 (Bacillus thuringiensis strain MYBT18246 plasmid p120416, complete sequence) position: , mismatch: 8, identity: 0.771

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttataaactagtaaaagaatatgaag	Protospacer
   * * *********.** *************.*

20. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP015354 (Bacillus thuringiensis strain MYBT18246 plasmid p120416, complete sequence) position: , mismatch: 8, identity: 0.771

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttataaactagtaaaagaatatgaag	Protospacer
   * * *********.** *************.*

21. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to CP016197 (Bacillus thuringiensis serovar coreanensis strain ST7 plasmid pST7-3, complete sequence) position: , mismatch: 8, identity: 0.771

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttacaaattagtaaaagaatatgaag	Protospacer
   * * *****.****** *************.*

22. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to CP016198 (Bacillus thuringiensis serovar coreanensis strain ST7 plasmid pST7-4, complete sequence) position: , mismatch: 8, identity: 0.771

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttacaaattagtaaaagaatatgaag	Protospacer
   * * *****.****** *************.*

23. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP021437 (Bacillus thuringiensis strain C15 plasmid pBMB240, complete sequence) position: , mismatch: 8, identity: 0.771

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttttataaactagtaaaagaatatgaag	Protospacer
   * * *********.** *************.*

24. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MT074141 (Bacteroides phage DAC22, complete genome) position: , mismatch: 8, identity: 0.771

---aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
tttagata---tttataaattagtagaagaatatgaaa	Protospacer
   *.***   *********** **.**********..

25. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MT074146 (Bacteroides phage SJC03, complete genome) position: , mismatch: 8, identity: 0.771

---aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
tttagata---tttataaattagtagaagaatatgaaa	Protospacer
   *.***   *********** **.**********..

26. spacer 5.29|1506357|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MN693405 (Marine virus AFVG_25M416, complete genome) position: , mismatch: 8, identity: 0.778

atcaactcctaaaatattcataaattttatacctcc	CRISPR spacer
aataacttcttaaatattcataaattttatccttta	Protospacer
* .****.** ******************* *.*. 

27. spacer 5.29|1506357|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MN693333 (Marine virus AFVG_25M417, complete genome) position: , mismatch: 8, identity: 0.778

atcaactcctaaaatattcataaattttatacctcc	CRISPR spacer
aataacttcttaaatattcataaattttatccttaa	Protospacer
* .****.** ******************* *.*  

28. spacer 5.29|1506357|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MN693092 (Marine virus AFVG_25M37, complete genome) position: , mismatch: 8, identity: 0.778

atcaactcctaaaatattcataaattttatacctcc	CRISPR spacer
aataacttcttaaatattcataaattttatccttaa	Protospacer
* .****.** ******************* *.*  

29. spacer 3.6|1489676|35|NC_022592|PILER-CR,CRISPRCasFinder,CRT matches to AP013501 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G19, isolate: uvMED-CGR-U-MedDCM-OCT-S24-C60) position: , mismatch: 9, identity: 0.743

aattaaatcttctatttctttatctgtattgttta	CRISPR spacer
ttgtaaaccttctatttctttacctgtattaacaa	Protospacer
   ****.**************.*******. . *

30. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046711 (Nostoc sp. ATCC 53789 plasmid pNsp_h, complete sequence) position: , mismatch: 9, identity: 0.757

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
aaaatttaaagaagaaataaaaaaaattgtagatgat	Protospacer
 .   . ************.**************** 

31. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MT774402 (CrAssphage cr7_1, complete genome) position: , mismatch: 9, identity: 0.757

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
ccataccattgaagaactagaaaacattgtagatgag	Protospacer
*  .** *  ****** ******* ***********.

32. spacer 5.26|1506161|35|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NC_022875 (Bacillus thuringiensis YBT-1518 plasmid pBMB0230, complete sequence) position: , mismatch: 9, identity: 0.743

aaatacattttataaattattaaaagaatatgagg	CRISPR spacer
ttcttctttctataaattagtaaaagaatatgaaa	Protospacer
   * * **.********* *************..

33. spacer 4.1|1499938|36|NC_022592|CRISPRCasFinder,CRT matches to NZ_CP035175 (Lactobacillus plantarum strain SRCM103426 plasmid unnamed1) position: , mismatch: 10, identity: 0.722

aattcctttataatgtattatttacaattattattt	CRISPR spacer
taaaaataagtaatttattatttataattattattt	Protospacer
 *    *  .**** *********.***********

34. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP011154 (Bacillus cereus strain CMCC P0011 plasmid pRML05, complete sequence) position: , mismatch: 10, identity: 0.73

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
tttcacaaaagaagaaattgataaaattaaaacagat	Protospacer
. **************** ** ******. *.  ** 

35. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP011152 (Bacillus cereus strain CMCC P0021 plasmid pRML04, complete sequence) position: , mismatch: 10, identity: 0.73

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
tttcacaaaagaagaaattgataaaattaaaacagat	Protospacer
. **************** ** ******. *.  ** 

36. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MT074142 (Bacteroides phage DAC23, complete genome) position: , mismatch: 10, identity: 0.73

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
tttgtttaaagaagaaataaaaagaattgtagaaaaa	Protospacer
. *  . ************.***.********* .**

37. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MT074139 (Bacteroides phage DAC19, complete genome) position: , mismatch: 10, identity: 0.73

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
tttatttaaagaagaaataaaaaagattgtagaaaaa	Protospacer
. *  . ************.****.******** .**

38. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to AP014321 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S33-C32, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 10, identity: 0.73

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
tggacaattagaagatatagaacaaattgtagatgta	Protospacer
.*    *  ****** ****** ************ *

39. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MT074140 (Bacteroides phage DAC20, complete genome) position: , mismatch: 10, identity: 0.73

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
tttatttaaagaagaaataaaaaagattgtagaaaaa	Protospacer
. *  . ************.****.******** .**

40. spacer 4.41|1502580|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP020080 (Vibrio campbellii strain 20130629003S01 plasmid pVCGX3, complete sequence) position: , mismatch: 10, identity: 0.722

atgtataaataaagaaacaaaccaaattgtagaata	CRISPR spacer
ctttatacataaataaacaaaccaaattggtagtaa	Protospacer
 * **** ***** ***************  ..  *

41. spacer 4.41|1502580|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP019296 (Vibrio campbellii strain LMB29 plasmid pLMB143, complete sequence) position: , mismatch: 10, identity: 0.722

atgtataaataaagaaacaaaccaaattgtagaata	CRISPR spacer
ctttatacataaataaacaaaccaaattggtagtaa	Protospacer
 * **** ***** ***************  ..  *

42. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MT074137 (Bacteroides phage DAC16, complete genome) position: , mismatch: 11, identity: 0.703

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
tttatttaaagaagaaataaaaaagattgtagaaaag	Protospacer
. *  . ************.****.******** .*.

43. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MT074141 (Bacteroides phage DAC22, complete genome) position: , mismatch: 11, identity: 0.703

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
tttatttaaagaagaaataaaaaagattgtagaaaag	Protospacer
. *  . ************.****.******** .*.

44. spacer 4.32|1501986|36|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP012100 (Bacillus thuringiensis strain HS18-1 plasmid pHS18-1, complete sequence) position: , mismatch: 11, identity: 0.694

tgataacttaataaaaaatatagagttaaaaaaagg	CRISPR spacer
caaacttcctataaaaaatatacagttaaaaatagg	Protospacer
..*   ... ************ ********* ***

45. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to KM216423 (Staphylococcus phage P108, complete genome) position: , mismatch: 12, identity: 0.676

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
acaagcaaaagaagaaatagagaaaattataaaaatt	Protospacer
    .****************.******.**.* .  

46. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MT786458 (Staphylococcus phage vB_SauH_SAP1, complete genome) position: , mismatch: 13, identity: 0.649

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
acaagcaaaagaagaaatagagaaaattataagaatt	Protospacer
    .****************.******.**.. .  

47. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MG557618 (Staphylococcus phage HSA30, complete genome) position: , mismatch: 13, identity: 0.649

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
acaagcaaaagaagaaatagagaaaattataagaatt	Protospacer
    .****************.******.**.. .  

48. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to KY779849 (Staphylococcus phage qdsa002, complete genome) position: , mismatch: 13, identity: 0.649

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
acaagcaaaagaagaaatagagaaaattataagaatt	Protospacer
    .****************.******.**.. .  

49. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MF001365 (Staphylococcus phage SA3, partial genome) position: , mismatch: 13, identity: 0.649

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
acaagcaaaagaagaaatagagaaaattataagaatt	Protospacer
    .****************.******.**.. .  

50. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MH159197 (Staphylococcus phage VB_SavM_JYL01, complete genome) position: , mismatch: 13, identity: 0.649

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
acaagcaaaagaagaaatagagaaaattataagaatt	Protospacer
    .****************.******.**.. .  

51. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MN304941 (Staphylococcus phage vB_SauH_IME522, complete genome) position: , mismatch: 13, identity: 0.649

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
acaagcaaaagaagaaatagagaaaattataagaatt	Protospacer
    .****************.******.**.. .  

52. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MK250904 (Staphylococcus phage VB-SavM-JYL02, complete genome) position: , mismatch: 13, identity: 0.649

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
acaagcaaaagaagaaatagagaaaattataagaatt	Protospacer
    .****************.******.**.. .  

53. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to MT554104 (Staphylococcus phage ESa1, complete genome) position: , mismatch: 13, identity: 0.649

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
acaagcaaaagaagaaatagagaaaattataagaatt	Protospacer
    .****************.******.**.. .  

54. spacer 4.10|1500532|37|NC_022592|CRISPRCasFinder,CRT,PILER-CR matches to NC_019448 (Staphylococcus phage GH15, complete genome) position: , mismatch: 13, identity: 0.649

cgtcacaaaagaagaaatagaaaaaattgtagatgaa	CRISPR spacer
acaagcaaaagaagaaatagagaaaattataagaatt	Protospacer
    .****************.******.**.. .  

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	3471472 : 3478800	8	uncultured_Mediterranean_phage(50.0%)	tRNA	NA
DBSCAN-SWA_2	4038285 : 4066447	37	Clostridium_phage(50.0%)	capsid,protease,tail,head,portal,integrase,terminase	attL 4029867:4029883|attR 4065242:4065258

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_022592|3471472:3478800|DBSCAN-SWA
TTTGGATGGACTTTTATTAGGTTATGAAGAAACCTTAGAGAAGAAACACATGAGTAAAAATACAATGGATGCCTATGTAAGGGACATAACCAGATTTTATAATTTTATAAAAGATAGGGAAGAGAATCTAGAAAATGTAGAAGTTGTATCTATAATGGCATATGTACAATATCTTCAAAAAGAAGGGAGAGCTATCTCATCTATAGTAAGAAATATAGTATCCTTGAGAAACTTTTATAAGTATTTGATGCTGAAAGGTGTTTTAAATGAAAATCCCGTTTTGTATTATCAAATTCCAAAGGTTGAACATAAAGTTCCTAAGATATTAACTATAGAAGAAGTAGACAAGCTTTTAGAAGCACCAAATTTAGATACTAATAAAGGAATAAGAGATAAGGCTATGCTAGAGGTTATGTATGCTGCAGGAATGAAGGTAATGGAGCTTTTAAGCTTAACTATATATGATATAGATTTAAAGCTTTCTTATGTAAGGTGTAGAAGCTTAAAAGAAGAGGAACGAATAGTGCCTATAGGTTCTGTGGCTGTAAAGTATTTGAAAAATTATTTGAATATAAGGCATAAATTAAATATATATAATTTAGATGTTTTGTTTCTCAATTTAAGGGGAGTGCAAATGAGCCGTCAGGGGTTTTGGAAAATAGTAAAATATTATGCAAAAGAGGCAAATATAGATAAAAACATAAATGCTTTTACGTTGAGGCATTCTTTTGCAGTGCATTTACTTCAAAATGGAGCGGATATTAAATCTGTACAGGAACTTTTGGGACATAAGGAGTTATCTGCTACTCAGATATACTCTTCAGTAATAAAAAGAAATAAAATTGCACAAGTATATAAAAAGTCTCATCCCAGGGCATAGAAAATATTTAAAAGTTAATGAAAAAAATAAAGGATTTGATGTTAAAGTCAATTTTAACATCAAATCCTTTATTTTTATGTGATAATTTTCTTGACTTAAGGAAAGAATACATCTCAAAGGAGGAGAGAAATAAAATGAGGAAAAAGCAAGGAGCTTTTAAAATAGTAAGCAATATATTAATTTTATTTTTTATTACAGTGTTGTGGTTACCAGTTGTTAATGCAGAACCTTTAAGTGAATCAAATAAAAAAGAGATGAATAGTACAGAATCAGGTTTAAATATAAATGCTAGGTCGGCATTGCTTATGGAACCTGCAAGTGGAAAAGTAATTTTTGAGAAGAGTTCTCATGAAAAATTAGAACCTGCTTCAGTTACGAAAATAATGACTATGCTTTTAACTATGGAAGCAGTGGACTCAGGAAGAATATCATTGTCAGATAAGGTAACCGTAAGTGAAAATGCAAAAAAGATGGGCGGAAGTTCGATGTTATTAGATACTGGAGAAGTTAGAAGTGTGGAAGATTTAATAAAGGGAATAGGAATAGCTTCAGGAAACGATGCAGCAGTTGCTATGGCAGAATATTTAGGAGGAAGTGAAGATCAATTTGTACAGCTTATGAATAAAAGAGCAGCAGAACTTGGAATGAAAGATACAAGTTTTAAAAATTGCACAGGACTTAGTGAAGATGGACATTTAACTACAGCCTATGATATAGCATTAATGTCTAGAGAGTTACTTAAGCATACAAGGATACTGAAATATACAGGAACATATATGGAGACAATATCAGAAGGCAGAAAAAGTCCTATAGAGTTAGTAAACCATAATAAATTAGTAAGATTTTTTAAAGGGTGTGATGGATTAAAAACTGGGTTTACCAGTTCTGCTAAGTACTGTATATCTGCAACTGCAACTAGAGATGGTGCAAGAATGTTGGCTGTAATAATGGGCTCTCCTACATATAAGGTGAGGAATAAAGATGCATCTATGATGATGAATTATGGATTTTCCAAGTACTTTGGAAAGAATATTTTAAAAAAGGGAGCTGATGTAGAAAAGATTCCTCTAAATAAAGCAGGAGATAGATTTTTTATTGCTAAAGCTTCAGAAGATTTAAAGGTGGTAGTTGAAAAGGGAAAAGAAAGTAAAATTACTTATAAGTGTGTAATAGATAAAAATAAAAAGCAATACAAAAAAGGCGAAAAAGTTGGGTATTGTGATGTATATGTAAATGGAGAGGCTTTAGGAAAAGTTAACTTATATAGCGACAGGGATGTAAAAAAGTTAGGCATATTTGGGAACTTTAAAGATAGTTTAAAAAATATTTTACAGAAAGGGCAATAGTTTATATATTTTTAATATATAATGTATAATGAAAACAGGAAATTCGATTGGGTTATTGGATTTTTAAAACTCGTTGAATTTCCTGTTGATTTGTTTAAGGCATTTGAAGGAAAATAACAAGCCAAAGATGCCTAAAGCGCAGGAAAGGAAAGAAAGACATGAATATTTTAAAGGCGTTTACTATAGAGCAAATACAAATTATAAATTTAATAAAAGCTATATGTAAAAGTAATGGTATAAAGGCTTATATAGTAGGAGGGGCCGTTAGAGATGCGTTCCTTGGAAATAAAGTAAAAGATATTGATATATGTATAGACAAAAATCCTAATTTTATTATAGGCAAATTGAATGGAATTAAATGCTTTCAGTATTATGATAAATTCCAAACAGCTTCTTTGTTATTTCAAAATGAGGTAAATATAGACTTAATAAGGTGTAGAAAAGAATACTATGCTAGAGATGGTGAACTTCCTATAATTGATCCGTCTAACATATACAATGATTTGAGAAGAAGAGATTTTACGGCTAATGCATTGGCTTATGATATAGTAACAGGAAGTTTAATAGATATTTATGGTGGATTGGAAGATATAAAAAATAAAAGCCTACAAAAGATACATTTAAATAGTTATAGAGAAGATCCTACTAGAATATTCAGAGCAGTAAAGTATGCAGTAAGGTATGGCTTTGATTTAAAAGATAAGGATGAAATAATTAATTGTGTGAATGAAGGCGTGTTTAATTTGATAAGCAATGATAGAATAGTAAAAGAAATATACCACTTATGTGAGGAAAAAATGTGGATAAAAAATATTTTAATGTGTGGTAATTTGAAGATTTTTAATGTTAACAGAGAAAAATTAGAAATAGGAAACGAAAACTACAATAATACAGATAAAAGAATTTTAAGATTATTTTATGCGCTTGAAGACAAAAAGTGCGCTCATATATTAGGTGAAAATTCAGTCTTGGATAGCAAGCTAAAAGTTTCGATAAAAAATTTTACAGAAAATTATCAAAAAATAGCCAGCCTAATTCTAAATGCTATGGATAATTATGAATTGTATAAAATATTAAAGGGCATAAATGATTATGGGCTTATACTTTTAAAATGGAATGACAAACTTAAGTATAAGATTTATAATTATGTTCATAATATGTATCATTATAAATCGTCTTTAAATGGAAAATTCATAAGTTCTATTGGAATACAAAATGGAAAAGCTATAGGAGAAGTTTTAAATTACATGACAAAGATTGAATTAAATTCTATGATAAAGTATGGAAAAAAATATTTAGTAAAAAATTTAGGAGAGATTATTTAGATGTCTTTAAATATAAAAATAGAAAATTTTGAGGGTCCTTTTGATCTGCTTCTTCACCTTATAAAAAAAAATAAAATGAACATATATGATATAAAAATATATGAGATTACGGAACAATATCTTCAGTACGTAAATAATATGAGAGACATGGACTTAGATGTGGCCTCTGAGTTTATAGTTATAGCAGCATCACTTATAGAAATAAAATCAAAAATGCTTTTACCTAAAACTCAGTTAAATGAAGATGATAATGAGGATGAAAAAGATCCTAGAAAAGAATTAGTAGACAAGCTTCTTCAATATAAAAAATTTAAAGCAGTAGCTGCATTTTTGAAAAAGAGAGAAATAGGCTTAGAAAAAATGTTTGGAAAAAAACCAGAGATAATTGAACAAGTGAATATGGGTACAAGTCCTGAACAATTTTTAAAGGGAATTACTATGTTAGATTTGTATCGGGTTTACAGTCATCTTATGGATAGCTATGTAAATAAACTTAACAACGGAAATGTCATGGGCAGGGAAATATCCTTAGATAAGTTTAAATTACAGGATAAGATGTTATATATACGAGAAATTATTCAAACTAAGCCTCAAATTAGGTTTTCTGTTGTTTTAAAAAAATGTTCTTTTAAAATAGAGAAGGTCGTAACTTTTATTGCACTTTTAGAACTTATAAAACTTAAAATAGTATCCGTAATGCAGTATGAAAATTTTGATGAAATCTATGTGGAAAGGATAATTGAAAATGAGAAATAATAATGAGAAAAGTACTAACAGCGAAATTGCTCAAGAAAAGGATTTAACAAAAGATGAATATTTTTCCATAATAGAATCATTATTGTTTGTATCTGGCGAACCTCTTACTCTTAAGCAAATTGCTTCAATAATAAAACTCAGTAGTAAACGTACAAAGGATTTACTTAAGGATATGACAGTTAAGTACAGACAGAAATCTAGAGGAATAAAAATTTTAAACAATGAGGATAAGTACAGTTTAGTTACTAAAACGGAAAATAGTTATTACGTTGAAGAATTACTTGGGAATAACTCAAGACAATCCCTATCTCAAGCATCATTGGAAACCTTAGCTATTATTGCTTATAAACAGCCTATAACTAGAATAGATATAGATGAAATAAGGGGAGTAAAAAGTGATAGGGCAATATCAACTTTGGTTGAAAGAAAACTGATAAAAGAAAATGGAAGATTGAGTGTGCCTGGGAGACCCATATTATATGGTACTACGGAAGAGTTCTTAAAATATTTTGGGCTTGAAAATATAAATGAAATTCCGAGTATTGAGGAATTTCATCTTGATTAATTTAGGTATATTCAAAAAATTATAGTGTATTATGTAAGTGAAGAAGAGGAATGACTATTCTTCTTCTTCCTTTTTTTCTTCTTCTTTCTTTTTATCAGAGTTATGTTTGGATTTTGGAGACTTAGAATTCATCATTCCTCTTATTACATCCATTACCTGTGGAATTGAATCTACTATCTTATCATAGGTGTTATTTTGATCTAAAGATAAAAGTCTTATAGAGTCACCTTTTGTGACTAAAAAAGCCACAGGTTTTACCGTAACTCCAGCTCCTGACCCACCACCAAAAGGATATTCTGGATTAGGTGATTCTTCATGGCTTACGTCGAATTCGCTTCCTCCAGATGCAAATCCAAAGGATACCCTTGAAATTGGTATTATAAGAGAACCGTCTTTTGATTCTACAGCATCGCCTACTATGGTATTTACATCTATCATATCTTTTAAATTTTCCATAGTGCTTTTTAATAAATTTTCTATAGGATGGTTATCCATAAAAATTCCTCCTTTACTATTCATTCTTAACTTAAAAATATGCATAGATTATAGTTTTTTTACACTTTTAGCTGTGCTTAAATAGTTTTATATACATATAAATAATTTTAGCTAAACTAATGTAAATTATACTTGATATTTCTAAATTAAAATAAAAACTGTTAAAAACAGGTTTTACGTGTAATTCTTTTTTCTTCACTACAAAAATATTTTTGATTAGAGCAAATATAAAAGTGCTTAATGTTGGTATAAGCCCATAGGTTATGGCAGTATAGGCTGCATCATCTAACCCATAAATGAGTTTTACCTTAATTTTTATATGGGGTTTAAATTTTAATTTTTTAAGGGATTTCAAATTTACTTTGAAATTATTTATGAGGAATGAGGACTTTTTCTTTCTTTCAAGAGGGGGTTTATTATCTTTTAAATTAAATTTGTTTATAACATTTAAATTATAAATTTTTAGTGAGAAGGCTTTATTGATATAGTTTATTTTTATTTTAAGAGGTATAGGAATAAATACCAAAACAAATAATATTAAGATAAATAAAATAAGTAATTTAATCAATATTTAAATCCCCCCATTTAAAAGGTTTTATTATTATAATTATTACCTTAATAGTGAATTATATACTAATTTAGAATGAGTTTTACTAGTAATATATTTGTTTTAGGGAAAAGTATTTAGTATAGCTAAGAGTTAAGAAGCGAGAGCTGAGAGTTATGGATGATTTTCTTAAGTTCTAAATTTAAGATTTTTGTACTGTAGAGAAAAAAATCCTCATTCACTATCTACTCTCCATTATCCACTTTTCACTTAATAATCTATTGAGAGGAAGGAGATAAACTATATAAATTATGAAATTTAAAAAGAGTTTATCATATATAGTAATAACATTTATACTTTTTAATATTTGCAGCTATACTGTGTTTGCAGATGATAAAAATTCATCTTTTCGAGAACCTAATATAAATGCACGCTGTGCTATAGCTATGGATAGTAAATCAAAAGTAATTATGTATCAAAAAAATGCTTCTGAATTAGTACCGATGGCAAGTACGACTAAAATAATGACAGTACTAGTTGCAATAAAATATGGAAAATTAGATGAAAAAGTACAAATATCATCTAGATCAGCAGGGATAAGGGGGTCTGTGGTAGGCTATAAAAAAGGAGAAAGCATAACTTTAAAGGAACTTTTATATGGACTTATGTTGAGGTCAGGAAATGATGCAGCTATAGCTATTTCAGAAGGTGTAAGTGGAAGTGTAGAAGAATTTGTGAAACTTATGAATGAATATGCTAGTGAAATAGGTGTAATAAACACTCATTTTAAGACACCTCATGGACTCGACAAAGAAGAACATTACACCACGGCGTATGACCTTGCAGTACTTACATCTATAGCTAAAAACAACACACTATTTAATGAAATCGTTAGTTCGAAAGATGTGGATGGACCACAAAATGGATTTACAAGAAGCTATCACAATATCAATAAAATTCTTTGGAAAATTCCAGATGCAAATGGTGTTAAGACAGGTTATACGGGTAAGGCAGGAAAATGTTTAGTTACATCTACAAAAGTTCAAGGAAATGATGTTATAATAGTAGTTTTAAATTGCCCTAGAAGATGGGAAGAAACAGAAAAAATATATAAATATGTTGATAAAAATTTTAAGTTTAACAAGTTATTTTCTAAAGGAGATAAAGCTCTTGAGTTAAGAGTAAACAAAAAGGATTTAAAGTTAGAATGTGAAGATGATGTTATAGTGCCTATAAAAAATGGATTCAAGTGCAGTGTTAAAATTATAAAACCTCAAAGAATAAAATATTCGGTTAACAAGGGTGATAGAATAGGAATGCTTTGTATATATGAAGGGGATAAAAAGATATATAGTACGTCCCTTAGAGCTTCCAATAGCATAAAAGTGAAAAAATTCATCAAATGGATATTTTAA

Protein sequences of DBSCAN-SWA_1

>NC_022592|3471472:3478800|3476397_3476838_-|WP_013237796.1|DBSCAN-SWA
MDNHPIENLLKSTMENLKDMIDVNTIVGDAVESKDGSLIIPISRVSFGFASGGSEFDVSHEESPNPEYPFGGGSGAGVTVKPVAFLVTKGDSIRLLSLDQNNTYDKIVDSIPQVMDVIRGMMNSKSPKSKHNSDKKKEEEKKEEEE
>NC_022592|3471472:3478800|3475022_3475778_+|WP_013237794.1|DBSCAN-SWA
MSLNIKIENFEGPFDLLLHLIKKNKMNIYDIKIYEITEQYLQYVNNMRDMDLDVASEFIVIAASLIEIKSKMLLPKTQLNEDDNEDEKDPRKELVDKLLQYKKFKAVAAFLKKREIGLEKMFGKKPEIIEQVNMGTSPEQFLKGITMLDLYRVYSHLMDSYVNKLNNGNVMGREISLDKFKLQDKMLYIREIIQTKPQIRFSVVLKKCSFKIEKVVTFIALLELIKLKIVSVMQYENFDEIYVERIIENEK
>NC_022592|3471472:3478800|3475767_3476343_+|WP_013237795.1|DBSCAN-SWA
MRNNNEKSTNSEIAQEKDLTKDEYFSIIESLLFVSGEPLTLKQIASIIKLSSKRTKDLLKDMTVKYRQKSRGIKILNNEDKYSLVTKTENSYYVEELLGNNSRQSLSQASLETLAIIAYKQPITRIDIDEIRGVKSDRAISTLVERKLIKENGRLSVPGRPILYGTTEEFLKYFGLENINEIPSIEEFHLD
>NC_022592|3471472:3478800|3471472_3472351_+|WP_013237791.1|DBSCAN-SWA
MDGLLLGYEETLEKKHMSKNTMDAYVRDITRFYNFIKDREENLENVEVVSIMAYVQYLQKEGRAISSIVRNIVSLRNFYKYLMLKGVLNENPVLYYQIPKVEHKVPKILTIEEVDKLLEAPNLDTNKGIRDKAMLEVMYAAGMKVMELLSLTIYDIDLKLSYVRCRSLKEEERIVPIGSVAVKYLKNYLNIRHKLNIYNLDVLFLNLRGVQMSRQGFWKIVKYYAKEANIDKNINAFTLRHSFAVHLLQNGADIKSVQELLGHKELSATQIYSSVIKRNKIAQVYKKSHPRA
>NC_022592|3471472:3478800|3476905_3477406_-|WP_013237797.1|DBSCAN-SWA
MIKLLILFILILFVLVFIPIPLKIKINYINKAFSLKIYNLNVINKFNLKDNKPPLERKKKSSFLINNFKVNLKSLKKLKFKPHIKIKVKLIYGLDDAAYTAITYGLIPTLSTFIFALIKNIFVVKKKELHVKPVFNSFYFNLEISSIIYISLAKIIYMYIKLFKHS
>NC_022592|3471472:3478800|3472485_3473697_+|WP_029170125.1|DBSCAN-SWA
MRKKQGAFKIVSNILILFFITVLWLPVVNAEPLSESNKKEMNSTESGLNINARSALLMEPASGKVIFEKSSHEKLEPASVTKIMTMLLTMEAVDSGRISLSDKVTVSENAKKMGGSSMLLDTGEVRSVEDLIKGIGIASGNDAAVAMAEYLGGSEDQFVQLMNKRAAELGMKDTSFKNCTGLSEDGHLTTAYDIALMSRELLKHTRILKYTGTYMETISEGRKSPIELVNHNKLVRFFKGCDGLKTGFTSSAKYCISATATRDGARMLAVIMGSPTYKVRNKDASMMMNYGFSKYFGKNILKKGADVEKIPLNKAGDRFFIAKASEDLKVVVEKGKESKITYKCVIDKNKKQYKKGEKVGYCDVYVNGEALGKVNLYSDRDVKKLGIFGNFKDSLKNILQKGQ
>NC_022592|3471472:3478800|3473855_3475022_+|WP_013237793.1|tRNA|DBSCAN-SWA
MNILKAFTIEQIQIINLIKAICKSNGIKAYIVGGAVRDAFLGNKVKDIDICIDKNPNFIIGKLNGIKCFQYYDKFQTASLLFQNEVNIDLIRCRKEYYARDGELPIIDPSNIYNDLRRRDFTANALAYDIVTGSLIDIYGGLEDIKNKSLQKIHLNSYREDPTRIFRAVKYAVRYGFDLKDKDEIINCVNEGVFNLISNDRIVKEIYHLCEEKMWIKNILMCGNLKIFNVNREKLEIGNENYNNTDKRILRLFYALEDKKCAHILGENSVLDSKLKVSIKNFTENYQKIASLILNAMDNYELYKILKGINDYGLILLKWNDKLKYKIYNYVHNMYHYKSSLNGKFISSIGIQNGKAIGEVLNYMTKIELNSMIKYGKKYLVKNLGEII
>NC_022592|3471472:3478800|3477696_3478800_+|WP_013237798.1|DBSCAN-SWA
MKFKKSLSYIVITFILFNICSYTVFADDKNSSFREPNINARCAIAMDSKSKVIMYQKNASELVPMASTTKIMTVLVAIKYGKLDEKVQISSRSAGIRGSVVGYKKGESITLKELLYGLMLRSGNDAAIAISEGVSGSVEEFVKLMNEYASEIGVINTHFKTPHGLDKEEHYTTAYDLAVLTSIAKNNTLFNEIVSSKDVDGPQNGFTRSYHNINKILWKIPDANGVKTGYTGKAGKCLVTSTKVQGNDVIIVVLNCPRRWEETEKIYKYVDKNFKFNKLFSKGDKALELRVNKKDLKLECEDDVIVPIKNGFKCSVKIIKPQRIKYSVNKGDRIGMLCIYEGDKKIYSTSLRASNSIKVKKFIKWIF

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013237791.1|3471472_3472351_+	tyrosine recombinase XerD	A0A1B1IQT7	uncultured_Mediterranean_phage	4.7e-12	26.3
WP_029170125.1|3472485_3473697_+	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	7.4e-32	32.0
WP_013237793.1|3473855_3475022_+|tRNA	CCA tRNA nucleotidyltransferase	A0A219YCT8	Aeromonas_phage	6.1e-23	35.9
WP_013237794.1|3475022_3475778_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	4.1e-12	28.2
WP_013237795.1|3475767_3476343_+	segregation/condensation protein B	A0A1B1IVT7	uncultured_Mediterranean_phage	6.9e-20	36.0
WP_013237796.1|3476397_3476838_-	GerW family sporulation protein	NA	NA	NA	NA
WP_013237797.1|3476905_3477406_-	DUF2953 domain-containing protein	NA	NA	NA	NA
WP_013237798.1|3477696_3478800_+	D-alanyl-D-alanine carboxypeptidase	A0A1P8VVG5	Erythrobacter_phage	1.2e-07	29.9

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NC_022592|4038285:4066447|DBSCAN-SWA
AATGGCTAAATTAAAGTTAAAAAACATTAAAAAAACAACAAATAAAAATATAAGGGAAATATATAAAGATTATTTAGAATATTGCATAAGTATAGGTCAAAGGGAAATGACAATCAAATCTAAACAAAGATATGGAACATATGTACTAAATAAAGTTGTTAATTTAGAAGATAAAATAGAAACATTAACAAAAGATAAAATAGAAAATTATGTGAATAAAATGCGTAGAGAAGGATATAAAGGGAATACTTATCAATCTTTTGTAATAAAAACGAGAGCTTTTTTAACTTATTGTTTTAATCAGAATTATTTAAAAAAATTTGATGTTAAAATACCAAATATTTTATTAGAAAAAAAGCAAATTTATATGGAAGAAGAAATATTAAAATTATTAAAAAAACCTAATATAAATGATTGCTTAGTAGGGGATTTTAGGTCATGGGCTGAAATAAGCTTTCTATTAGGTACAGGATGCAGGGCAGAGACTTTATTAAATGTACATGTAGAAGATATAGATTTTAACACAGATAGTATATTATTTAGGCATATGAAAACAAAAAGGCAAATCACAGTACCATTGTCTAATACTTTAAAAGTAACGTTAATAGAATATATACAGAGAACAGGGTTAAAAAAAGAAGATTACTTATTTCCTCTATTAAATGGGGAAAAAATGAGCTATGATACTTGTCATCAAAATTTGCTTAATTACTTTAAACATAGAAAAATAAAATTTCATGGTGTTAATACATTTAGGAATACCTTTGCTACTATGTTCATTAAGAACGGCGGCGATATCTACCGATTAAAAATTATATTAGGTCATTCTGAGATAAAAACCACAGAAAGATATATAAACTTGTTACCACTACAAGTAAAAAACGATATACAAAAGTTCAATCCTCTTGATGTTCTTTCTAAGAAAAACATAAGAATGTCTGTTAAAAGGGGAGGTAGACGATAATGATTAATTATACTATTATAGATAATTCTACTATCACTTACAATATTTCCGATAATGCTTATAGAATTTATAATTTTCTTTTATCTATGTGCTACAATAAAGATCATTGTTATCCTAGTCAAAAATATATATCTGAAAGGCTCTGTAAAAGCGTTAGAACGGTACAGAGAGGTATACAAGAATGCTTTAAAGCAGGATTAATTTTACGAATAAAAAGAAGAGGAAGTATATCTAACGTATATACGTTACTAAAAACATCGACGTCTAATGTTGTAAATACAGTAAAAACTACTATAGATAAGGTTAAGAAAAGCTATACTAAAAAGAAAAGCCTATTCAATGATTTTCCTCAACGTAAGTATGATTATAAAGAACTAGAACAACAATTGCTAGGAAATGCAGTATATGATCCTAAAAAATTAGAATAAATCAAAAAAGTAAAAGTCCCTTAAATATCATAGCAGGATATTCAAAGAACTAATACTAAAAAAACGAAAATCAAATATTTATCATGTTACTTATATTATAAACTATTTTTTTGAAAATATCAAAATTTTGGTTTATTAAATTCGCACTTTTTTTAATCTTAAAGAATAAGATTTATTTGTGCTACCTAAAATTATTAATAAAAATTACTATTTGTAATATGCAATTATATTTTTATAATTATTAATTGTAAATTAGAGATAGTAATTTTATTTTTTGTAAAAATTAGTATATAATTATGTTAATACGACAGTATTGTAGTTTTAAATATGAAATATGTAATATAACAGATACGCAACCGTTCCTATACAAAGAAATAAAGCTTAAGAATTAATAACTTAATATATAATATGATGGAGTAGAAATTATGGTTAAAAATAGATTAAAAGAAATTAGAATGAAAGAATATATGATGAATCAGAAAGAATTTTGTGAAAAAGTATTAAATATAAGTAGATATACGTATAATCCTATAGAAGGAAATAAGGTTCAAGGAAATATTGAAACAGCAATGAATATAGCTAAAGCTTTAAAAAGAAAAGTTGAAGATATTTGGTATTTTGATAATGAGGCTAAGTAAAGCCTTATTTTTTTATATTTTTGTGTGTATATGGAAACTTTGTTTTTATATGAAAATTTTGTGTGTGGACATGCAATATTTAAAATATCCCACATATACTTATATTGTAGAGTAAGAAAGGTATATGTAGGAGGTATAAAAAATGGTACAAAAGATTATTAGACTATTATTAACAAAGGTTATTCCTTCACCAACAGGTAGTAGGTATGTTGAGGATATTCTGTATAACCAAAGGGTTTATCCTATTTATTCAGAAGTCCAACAAAGACTTACTTATTGCTTAAAAAACAAACTAATCAATCGTGATGAATTAATGACTTTTAAGTATATGCTAAATAAGTATATTAGAAATTCTTATGCCTATAAGGATAAGAAGTGGAAAAATGATGCTCATGAAATATTTACAAAACTTAAAAGTCATTATATCAAAACAAAAGAAATGAAAAGGCTATTGAAATATGTTAATCAATTTTATATTGATATTCCAGAGCCAATACAGAAATTTAAAACAGTATCTTATTTAAAAGTAATTAAGTAAGCATATCAAAGCTTATAATCCATGAGGAAGAACATTAATTTATATATTGCTTACCATAGCTTTATTTTGTTCTTTCTCAAAATCTCTACATAGTATAAACAATTTCAGGGAGGTTTATTCGATGCTAGAAATTTTAGATTATTATTTATTTTATTCAGATCGATTATTAATTAATTTTCTTATACAGCATATATCAGCACAACAATTTTTTATGGGAACATTATTTGTTTCATTAGCAATGGATTGTACTTTAGAAAATAGTAATAAAAAGAAGAAGGTAAGTAAATAATGTTTGTAGAAATGGGTTTAATTGGTGGAGGTTGGTATTGTTACGATAGGATAAAAAATAAAGATATATATTATGTAAAAAGTAAAATTAAAAAAATGTTTGAAAAGAATAATATTGATTATTACCCTATTTATAAAGTTAATCGTAAATTACCTTGGGGATATGAAGTGCTAATAACATTAGGTGAACATGGATTTAATAAATTAAATAATTTACAAGATGAAATACAAACTTCTATAGGCTATCCAATTACTATAGAACAAAGTTTAAATTATGAGTTAGGAATTATAAAAGTAATTGTAAATCCACCTAACACAGAGACAATATTTGCACCAGTTAAAGTAAAACCTTATGAAATATTTGTATCTTTGAATAATACTAATCAAAATCTTATCGTTAATCTACAAAAATTCCCTCATGTCTTGGTTAGTGGGCAAACTGGTTGTGGCAAAACCGAAGAAATTAGATCTATTCTTACTAATTCAATTTATTTTCATACTGCAAGAGATTTAAATTTATATTTTGCAGATTTAAGTGATATGTGTGATTTTGATATATTTAAGAATTGCAAGCAGACAAAAGCTTATGTAAAGAATATTGAAGATTCAACCAAATTATTTGAATATTTAATGCACATATATACTAAAAGACTTCAAATATTCGAGAAAAATAATTGTAAAAATATACAAGAATATAATAGTAGATTTTATGGTAAAAGAATGGCTTATAATTTTATCGTACTAGATGAATTTGCAGATTACTTTCCAACGACAAAGTTAGATAAGAATTATAAACAGAAGGTATTGTGTTACAACTATTTAAAGGAATTTGCACGTAAGTTTAGGAAAGTAGGTAGCTTTCTAATTTGTGGAATACAAAGACCAGATACAACAGTTCTTGATCCAAATTTAAGAAGCTGCTTATGTACAAAAATAGGATTCTCACAAAATTCAGATGCTTCAAGTTTAACTGTATGTGACACCGCAGAATTAACCAATATAGAGAATAGAAAAGGTTTATTAATGTATGGTAATAAGAGAGAATGGTTTTATAGTTTAGCTATAGATGATAATTTAATAAAAGAAAATATTAAAAATAGCATACTTGAGAATAGAGGCTCTTATACAGATTACAATAAATTTTTAAATACAAATAATAATGCAGTACCAATGAAAACCAAAAAATGTGAAAAGGATGATAATCCAGGTATTAAGAAAGATAGACCTAAAACTAAAACAAAGTTAAAGGTGAAAAAGAATGTTAAGTAAGCATAAAAGGGAAATATTAAATTTTATACAAGAGGAAGGAAGCATAACTATTCGCCAATGTGCTAAAATTATATATCATGGACGGAAATATGGCTATGATATGTCAAGGAAAACACTAAGAAGTTTATATCAAGATAAAGCAATTGCCCGTTATAGATATAATATGACCGCAGAAACAATTTATTATATTAACCAACGTTAGGTATTCACGCACTCAAATTACTTGATGTATATGCAGAATTTATTGATTTAGGTTGTACAATTGAAACTTTTAAAAAGAAATATAGAATTTATACTAATGGTAAAAAATATAGAGAAATTGATGCACTATTAGAATTAAATTATCAGGAATATTTTATACCACTAATTATTGAAATAGATTATTCGCACATGACTTCAATTCAAAAATTACAAGAGATATATGAGAGCAATCACTTCCAACAATTATATTTGAAAAAGTTGGGTGAGGAAATATATCCAATAGTTATAATTGTTAGACCAGTTACAACTAATTCGTTAGTTGAAGATCATACTTTTTCAATTTTATACTCAGATTTTGAGTTATCCAATTTGGCAAAAGTTTTAAATAATTAAGTTGCCACAAGTTCGGGTTGTCACTCTCACTATTACACTTCATTTCATTATTCTATTGTCTTGTAAGAATCCCATAAAATCAATAAGTTAAAGTATAAGAAAGTACCTATATAGTAGTAATTACTAAGGTACTTTTTTTAGGTATTATATTTAGTATAAAATAAATAGAATTTACCCATAATGTTTAATAAGAGGTGGTAAAATGTTTTTAGTAGATATATTATTTTTTATTATAGATAACTTTACTTTAATATTGATTGGTATTGGATTAATAATAATAATATATAGTTGGATTACCATATTTGTAAATAAGGATTATGAGTTTATAGCAGATTACAGTAGAAAGTATAAAAATAGAGTTTTAACTATAAAGGATTTAGATAAAATTAAACATGAAATTGAATATATGGAAGGTAGACAATTTGAGAGATTTTCTGAATGGCTATTTAAAAATATAGGCAAATATAAAAAGGTTACTCTAACGCCAGCAGCGAATGATGAAGGCAGAGATTTAATTTTAATTGATGATGACGATAACACTATATTTGTTGAGTGCAAAAGGTATACAGAAAATGCAACAGTTACAGAAGATTTTATGATTGGTAGAGAGATATGCCAAAAGTTAGTTGGAGCAATGGTTGCAGATACTATAAAGCGAGGAATTATAATTACTACAGGAAATATACATCAAAATGCATGGGATTATATAGTTAAATTAGAGAAGAATAGTGATATTAGAATAGAAATTATAACGTTAGATGATATTATGAGAATGATTAAAAAAATAAACAGTCCAGAAGTTTTAAATGTTGTTGGGGCTTGAATATTAAATTAATAGTAGAAAGACTAGGAAACTAAATTCTGGTCTTTTTTTATTAATCAAAGTCTTCGTGGTGATCAATGACTCAAAAAGTAGAAGAAGGTTCAACACGTGATATAATAGCAGACAAAGCATAACTATATTTTTACCAATTTTTATAATCAAATCATAAATCCTAAATAATAATATACATTATATAACTAAAACATACAAATTATGTTGAGAAAAATGTTAAAATGTATTACAATCATTTATAAATATATTTTAAATTGTAGGCAATACAAAATACGGAGGATGTAATATAAATGGAAAATTCTCAAAAAGAACTAATGAAAGATTTTGTGATAAAAAATAAATTTTCATGTTATAACGATGATATAAAAGATATGGCAATCAGAAAATTACAAAACGAAATGAAAAAGGAATTTTTTGATGATATTATTGATTATAAAATACACAATATAAAAGATATAATGACAATATTTTTCAAATTTAATAATAATTTAGGTGTAAATTTACATTGTAATAGAATAATATATGATACATTAAGAACACATATCACATTTAGATATGAAATTGTATGCTATTGCGATAAAAAAAATCCTATATATAGTGAAGTTATAAGAACTTTTGAATATATGAAAATAGAAAGGATAAATGAAATATTTGAATTTATTAAAAGTTTACGAATATATTTTTTTGATATCGATCATCGTAAGTATAAGTATGATGGTTATGGTCATTTTGAAAGAAAGAAAAAGGATATGGTTAAATACATTGATAAATCTATAGAAGAAATTCTTATGTATGGGGTAGTAAAAAATATTAACTAAAGATAAGAAAAGGAATTAAATATGTTTAATGATAAGATGAGGTTAATTAACGAGACTGTTTTTATAGATACTATTAAAAAAACTAGTATGTGTCTAAAGAAATCTAATGATATTTTAGAAAACTTAAAAGATGGAGTTACTAATAATGAGTATTATAATGCTTTATATATTTTAGATAAAACATGTAAAATTTTAGAAAATTTATCAGAAATGAATTTTAAAGAAGCAAAGCTGTATACTAAATTGATGTTACATAAAAGTGGAAATGAAGAGATTGAAAACAAAGTTGAAGACGATAATATTAAACAATTTTCTAAAGAATGAATTGAAGAAAACGCAGCAGGATTATCATTAGTCCTCTGCCTTTTTTGTCTAAAGTGAATAAATTTTTATAATAATTCAAATTATTTAGTATTTAATAGAGGAATTTCCTTCTACATTGTAGAATATTTACAAAAGAAGGGAGATGTTATCTATGATAATTAATCTAAAAAATATATCAGAGAAAAATATAAAAAATCTGTTGATTAATGGAGATAAAATTGTTAGAAATATAAACCGAATTAGTAAAAATACAAAAAATATTATTAAATTAAATGGAGCAACCTATGCTAAATTAAATATAGATATAAAATCATATGGATCTATATTTAATTTTTTAAATCAAAATTATAAAATGAATGAATATTATACTGATGAATTTATAAAGTATTTTATAAAATTTATGTTTGTAAATTTTAATGATGTATATTATGTAGTTTATGGCAATATAAGTGATCCAATAGATATTAAAGAATCAAAATTAATGCTAACTGGTATGTACTTAAACAAGTTATATTTAACTCTAACAGGACATGTATTTATTGAAGAACCAGACTTTGATATGAAAGTAATTTTAACTTATACTGATAATAAACTTTTAATAGATAAATTTGACAACTGGGGTATAAACCTTATTGATTAAACTAAGAAAAAGGTAGAAGAATATTTATTCTTTTACCTTTTCTTCATTATCTTTAATTATTTCCATTACATCTGAAAGATCACATTTTAAAACTTCACATATTATCTCAAGTAGAGAAAATTTTATGGAATCAGTGTTATTTGCAGCAAGTTTTTTTAAATTAGCATAATTGCATTTGCATTCCTTACTTAACCAATAGATTGTTTTCCCTTGTTTTTTTAGCTGTTCATTTATTTTAATATGTATCATAATAATTGCTCCCGTAAGTAGTATTTCTAACTGTATTATATACCTTTGAGCAATAGTGGTCAAGAAAAATAAAAAAAGTATATTTTTCAAATATAGTGCTTGACCGATAGTGCTTGAGGCAGTATAATAAGATTATAGAAAACAAACATAATTAAAACAAAGTTTTCTATTAATGTAATTTATAGCTTATACAAGGGTGGCAACCTAATAATTGGATGGGGGATAATTATGGTATACTATCATTTTACACCAATTGATAACTTACCAAGTATTTTAAAATCTAGAACATTAGTTAATAAAAGTAATGGAGTGTTTGTGTGTGATAGTTTCGAGGACTTATGTAAATTTGTAACAATTTATCGTAATCTTAATGGATATAAACTAGATGATTTGGCATATATTAGCTTTGAAACGGATATGGAACTAGAGGAAAGTTTTGATCATGACAAAGAATTTTTTAATGGTGCTAGAGCCTATTATAGTTTGGATGATATAGAAATGGAAAATATATGCGTAAGTTTGTTTTCATAGAAATGAAATATAAAAAAAGCACCTAACAACCCACAAGGAAAATGTTAAGCACTAACTCCAATTAGATTATAACATAATCCTTATGGAAATCAAATAGTAGGAGGCTAAAACATGAGCAACGTATTAGAAATTAAGCAGCAACAATTACAGGAGAAAATAGGACAAATAGTTCCTTGGGATTATGTGCCTAAAGAAAATATTGAGCACGTATTTACAGTGTATATAAGTGGCAATATGCCTATAAAAATTAAATCGTCACTAACTTACAAACAATTTTGTAAAATATGTTAATTAAAAATTAAGAGGAGGATTTTATTATGGAAATGACAAATATAAAAAATTATAGTTCAGAGGATGAGGAAAGACAGATTTTTAATAGTATAGTAAAAAATGCAGTTGAAAGAAACTTAGGTGAAATTAAGGGACAAGATGTAATACTTCATTACAGTGGCGATATGGATTGTATCTTAAATATAGAGAATACACACGTTGCTACAGTTGCTTGTAAAGATAGAAAGATACATTATATCAGACTTTATGGAGATAACGAACAAGAGGTTGACATAGATGTTGATAAGATCAATTCTATTCAGAACGAAATTGACATGATAGATTTTTATATGCAAAATAACAATTTGATAACTATTGAGTTACAATAAAAGTATAATTTTATCTACAATTTTTAGACAACACAAATAAGGCTATAATAATGTAAAAAAACTAGCATTTATTACCTATAACCATATAATTTAAAATATTAGCAAAATATGATAAAAAATGAATTTGTATGAATTTTAAAAACTTGCTATTATATAAGGTACAGGAAGAACTCAACTCTTTTTGTACCTGATAGTAATTAAAAAAAATGTTCTTTGATAATTCAATATAAAATATATTTTTTATTTACAAATATTATTATAATCTTTAATTTTTTAAAAGTCAACAAGTTCGCATAAATTTTTATTTAACGAACTTGTTAAGTAAAATTACCACTTTACCGTCGTTTTTTGATTTTATAAAATAGCTACAATTGTTGATACATCTATGATTACAGGTTTCACTATCTTGGGATATATGGAGAGTAAAAAATAAAAATAGGGGGAATTTTATGATTAAGTATGTAAATAGGACAAGCAAAAAATTAAGACAAAAGGTATTAGATAAGGCACTAAAGGAAGAAATGGAATATTTAAGAAAGAGGTGTTTTCCTTGGCAAAAACAACCGTTCTTATATAATCCAGTAGTAGTTCATGAAAAAGTATTTTTACCAGACAAAGAAGAAGGTAACACATTAGGCTTATATAAATACAATGAGAAGGAAAATAAGCATTATGTTTATGTAGATAAAGCACATGTTTGGGGAGTACATAAAATGCCTGTAAGTTATTTAAGACAGTATTATTACAAAGAAGTTAGAGGAATTTTAAGACATGAATTAATCCATTGCTTTTGTCAGGAAAACTGGAATTATAAGTACATATCTTTTATTAAAAATATGGAACGAGACGCATCACCAATATTTCTTGCAATATTATATTTTTGTGATGGATATACAGGGCATAATTGTACAAAAGGATGGATGCAAACAGAGTTATATAAGAAGATAAAACAAAAGTATTTTAAAAATTATAAACAATTAGAAAAATATCTGGAAGATATGTTATGGAAATTTGCAATTCAGATTAATAAAATAAAAGAATTTACAAACGAGAAAAATTTTAAACTTGGTTTAGATGCTAATTATACAAAAATTTCTAATGAATTTGAGTTTGCACCTAGGAATAATGGACTAACTAAATTTTCTGAAATTAATTTTCAAGATATATTTTTTTCAAAATATAATAAAGATTTAAAAAATAGAAGAACAATTAAAAATGTAAGTAGGATATGGGAAATTGGTTGCAATGTAGATCCAAATAGACTCATAGAACTTTACAATAGAAAGCAATATTGTGAAGCTACATATTATAATACTAAAAAACGTCTAATAGTTCCAAATGCACAGATAACAAAACCAGAAAAGATTATAAATATAAAAGAAAATAAAAATTTTTAAGGGGGGAGTGATGATTATTTGAACATAAAAAGTATAAAAGTTGGACAAGTGATAAAAAATTATAAAGAGTTGTGTTTACTTATGGAAGAAAAAGTTTCTGCTGGAGATACGAAAAAGAAACAACTAAAAGAATGGGCTAGATATTTTAAGTGGCATAAAGAAGGTCAGAAATTTATTATTGATGAAATCTACAAAGATCCTTTACCTAAACAAGATAGAAGAAAAAATAATAGCCATAGCAAGTACATAGAAGAAATTAAGGATATTTTAACATACTATATACATGGACAAATACAAAGAACTGGAAATAATGTTGTGACATTATCTATTAGCGAACTAATTAATATATGTGGCTTTGCTAATAATACATACTCATTAAGTACATATAAAAAGAAAGAATTAAGTGACATATTACATATTGAATTAGTAGCAATATATAATTTTTATTCTTCTACTAGGACAGAATTTAAAAGAATTATAGAACGTGCATTAAAAAATTTGAAAAGTAGAAGTGTATTAATATATCAAGATACTTTCATAGTTGCCAATGTAGACAAAGGACATAATAAAGTAGATAAAAGACCTGCGACAGATGAAGAATATAATCTGATATTAGATACTCAAAATGAAATGCTAAAACATTACAACATGGAAAGCTTTAAAGATTTATTTTTGGCTGGTAAAAAAGTATATAAAAGTTTTATGAATGATGTAAATAAAGAATTAGAATGGGATTTTTATTATCCTGCATATAAGATAATATGTGGTAAAAATGCAGTAAAAAGAGAATACAAAAAAATAATAGATAAGAAAAAACAGTTGAATGATAAATCTATAGAAAGATGTAAAAATTTATTTAAAATAGTAGATGATAATTCCAATGAAAATAAATTGATAAATAATCTCATTTCATTTAAAAACTATAATCCTAATATTGATGATTTAATTCAAATCCAATACCAAAAAAATAAACATGAATATTTTAAAAAGTTAAATGAAGAAAATTATAGGATAAGTAAAATTGAAGAGGATTATAAAAATAAAGATGATGTTTCTTTATCTGATTTAAGTAAATATAAATATAAAACTAAAAGACATAACGATCATGAAGAATATTGGAGTTATCTACTAAATGAAATTGATACATATAATATCCAAAATTAAAAAGTTGAATGTTTTCAAACGCTAATTAAAAGGGTATTTAATATACCGTCAATCTTATTCAACTTTTCAATACAACATATATACATAAAAAATCTAATAACCATTAATTATGATTGGATTTGCGACCCGTAGGGGAAAAGCAAATACATATCATAATTATGAGGGACTTTTAAATTGTGTAGTGTAACGGAACAATTTAATAAGTACCGAACCTCTTATATATTAAGTTTAATTATAATAGTAAATTTGTTGTCAAAGACATTTTCAATTTATTAAATTTGTTCCGTTCCCTTTTGGGTCACTCACAAATATTAATAAATTGAGAGTTGGATTTTTAAAATATAAAAAATAAAATTGGGGGAATAAAATTATGTTAAATAAACAAGTAAGAATGTATTGTGTAAAATTAAATTTAGTTAGAACTGAAGAAGAGAAATATATGTGTTTGCAGAGAATAAGAATGGAACAAATACGATTTTTCTTGAAAAAACACATGTCTAATATTGTAAGAAGAGAATTAGAAGTTAAAAACTGGACGGAAGAATGTAGTAAATTATTTAAAGAAAAAATAAATGAAAATAAATATTATACATATATAGAATCTAAATTACGTGAAATTAAAAAAGATATACATAAATTATATGTAGCTAATAAAGATTTAGATAGAAGTGTTAAAAGTAAAGATATAAAAACAAAAGATATAATTGCAATAGGTGATAATAATCTTGTACGAGTGTTAGGACTTAATTTAGGAAGCTTTACAGATCAAATTATTACAGTTAAAGTTGGCGATATGGATAATATCATTGTAGAAAAAATAGTTAAAGATGGTTTAACTATAGATAAACAACATTATATTTTCTTTACAGCAGGAGCAGGACAAACAAGACAGAAAAAATTTATGATGATAAAAAATGATGAGGCTCTAAAAGATGTAATGTTAACTTTAATGAATGGACTTACTATAGAAGAAATTAATAAAAAGGGTGGAATGAATATATCAAAATTTCTAGCATATTTGAGTTTAAATAATTCTGGTTCTACTGTATGGGAAAATTTTGATATAGATAGATGTATAGTTGTTGCAGATTTTGAGACAATGGTGTCTGCTAAAGTAGATTATATTAGTAGGAAAACAGAGAAAGTAGAATATAGAGATAAGCTAGATAGAAAAAGAACTAAAGATGTTGCTAACTGGACAATAGATAAAAATAAGACAATGGATGTTCCAATACCACATTTTGATGGATTGGGTATTATGTTACCAAGTATAGCACAAAAAAATACCCAAGTTAGATTACCCTGGATAAAAGGATTGCTTACACCATTTAATTATATTGAATATATTAAAGAAAAAAGCTATGATACAAAAATTACAGATATTTATGGACAAGAGTATGACATTATAGAAGATAATATACAGATTATTTTTACAAAGAGCCAGTTCAAACTTACAAAGTATTATAACGATTGGCAGGAATATAAAGATAATTTTCACAAATATAATTGTACAGCTAATATTTGTATGCAAGATGAAGAAAAATCTGATAAATATAAAGATATGCAAATTAACTACCAAATGTTGCAGCAATTAATCAATATATCAGATAAACAAATAGAATTATTATGTAAAGACTTTAAAAGTTTAATTAGAAAGGTACATACTGATAGAAAATCTCAATTAGAATTTTTAAGTGCAACAAAGAAGAACGAACATAGAAATTATTTTCAAGAAGCATTAAGAATATATCCAGAAATGTTAAAATCTGCTTATGTTAATAAAAAAATAAGTAAGACAATTACAAAAGCTAAAAATGATGCTTGTTGTGGTAAGATAAAGATTAAAAATAGTAAGAGAATATTTATACTTAGTGATCCTATAGCATTTGTAGATTGGTTATTCGGGCATATAGAAGTTCCAGAAGGCTACCTAAAAGATGGAGAAGTGTATTGTAACTTGTATAAAAATGATGTTAAATTAGATGTTTTAAGAAGTCCAAGTTTGAGTTTTGAACATGTTATAAGAAAAAATGTAAGAGCAACTAAAGGAAAATATAAATGGTTTATCACCAATGGAATTTATACAAGTACCCATGATGTTATCTCAAAAACTTTGGCTTTTGATTGTGATGGAGACGAAGCTTTGGTTCTTAGTACGGATTGGATCATTTCTTTAGCTGAAGAAATGATTGATATTTATGATATACATCCTATATATTTTGAAATGGGTAAAGCTCCAGCAACACAGATTAATAAAGACAATATAGTTAAAAGTTTAATATTTGTATATAAAAAAAGTAATATAGGTAAGATTAGTAATACATTGACGAGAATGTGGAATTCTGAAAATCCAATGGATGATTATGAGATAATGCAAAAGCTATGTGCTTATAATAATGATATTATAGATTCCGCAAAAACTTTGTTTCTTCCGAAATTACCATCAGATGTTAATGAATTTATTAAAAATGATAAGTATCCGTATTTCTTCCAATATGCAAAAAATAAAAAAGAATTACAGTGTAAACCTATGAGTAATAGTGTAATGGATAGAATTTGTAAGAATATAGAAAACATAGAAAATACAAAATTTGATTATTCAAAAGGATTTGGAATATTTAGAGTAAAAACATTAATGTTTAATCAGGATAACATCGAAGTTAATAAGGATGTAATTATTAAATATTTAGAGATAGAAAAAGATACGACTGATAAAATTGATGAATATTCTAAAGAATTTACTAATGAAGATGAAGAAGACATGAAGAAAACAGATTTTAAAGAAATATTTTATGGTTATGCAAGAAAAGAATTTGAAACTTGGGGAAAAGAAAACAATATAGATATACTAAATATAGTAGATACTTTAATTAAATATACTTACAAAACGAATGATTTAAAAATGAGTTTTCTTTGGAATGTTTTTGGACAAGAGATTCTCAATAATATAAATATAAATATTAATAAACCTTTAGATAATGGATATTTAATGTGTGAGGACTGCGGAAAAAGGGTAAAAAGAGAAACAAATAATCAGAAAAGATGTCCTAAATGTGCTAAACAGAAAAGTCATAAAAAAGTTAAAGGGGATTCTAAACAAGTCTCTTAATCCTTATAAATACAACGTTTAAAGGTAATTAATAACAAAAAATATTTTTATATAAATTGCTATAAATGGGATAAATACTAGGATTAGAGCATATTTACAAATTCCTAAGATGGAATAGAGATAGAGTGAGAACTCGTAATAAATCAGTAAGGGAATGAACTTACACTAGGGTAGAATAATATAATTCTACCCTTAAAAATATGCTATAGTTTGTAATGTAGTAAGTATACAAATACACGTCCCATCCCAAAGGAAATGTTCATATAGGGAGCTGGTTACTCCCTATTATATTATTTTTTAATGCTTAAAAATATGTATACATAATTATTATATCATATATATGATAATTTGTAAATATAAAAATAAAAATTGGAGGAGAAATATGCTTAAACTTAAAAAAAAAAAAGAAAATTGAAGTTAAAAGAAAGTGCGGATTAATTGGGAGAAGCCCACACGATCCTGACGATTTATTTTGGGATGAATATGGAGTATATAAAAAAGTATATGTAAATAAATTTGATAAAAATAGGGGGAATGAATAATGACTAATTGCAAAAAAATGTCAAATTTAAATGAGTATATAATTAGAAATTTACATATGGAAGTAATGGATTCAAATATTGTTCCTGTAAAGGATGAGATTGCAGCATGGAAAGACGCTAAACAGGATGAAAATGTAATTAAAAATTTGGAAAAGTATATAGGATATAATTGCTTATATGCTATAGATACATTAAACGGACTTTTCAAACAAGGATGTGTAATTATAGATGATGATATGAAATATATTGGATTTGTAGAAACTGTTTAATTTTTTTATTTAAAAATGGTTAACTTTTTACAAATACAATATAACATATAAAAAAATTAATGTCAATAAAAAATTTTAAAATATGATGATTCTTTTTTAAAGAAAACAGAAAAAATGAAAAACATCACATAATTTAATTAAGTAAATAAAAAATTGGAGGAGTTAATATATGTTAATAAAGCAAGGTAAAATAAATAAATGTGGAATCTATGGAATTAAGACAAACCAAGGCAAAATTTTATATGTGGGTGGAGCTAAAGAATGTAATGATGCTTATAGTAGACATAGGACTAATTTAATAAATGGTGCATATTGTGAAACCAATAAGGATGAACTACAAACAATTTTTAATACTGAACAAGATGATTTAATATTCTATGTTATTGAAGAATGTAAAGAAAATGAATTAGATAAAGAAGAAACTAAATATATAGAATTATATTCTAAGACTATCATAAATTCAGATATGAAGGGTAAAAGAAGGAAAAATAAATCCACACCAGAGGAAACAAAACATAGGAGACAAGCCAATGAGGGGGAAAATAATCCTCACAATACAAAACTATCTGAAGAAGATGTTTTTGATATATTGGATATGCTTAAAAATGGTGTGAATAGAGATATAATTGAAAACAAATATGATATTTGCAAGGGATATACATATAGAATTGGTTGTGACCGATGGGTAAAAACATATAACAAATGGAAAATAAAAAAAGAAGCATCTACTGCAATAGATACTTCAAATATTTGTACATCTGCAAATGTACAATTCGTTTCTTATAACTAATCATAATTATAACATATAACAAATGAAGATATACATAAGGGAGCAATTTTTTATTGCTCCCTACTTGATTTTTTTGTAATAGGAGGATTTAAAAAGATGGAAGAAGATAGGAAGAAGCATATAAGAACTAAGTCTCTAAATGCAATTACATATATTTTATATAAAAATCCATTACAAGACTTAGAATTTTGGAAAGATGAAAGCAACGGACAAATATTATTTCAAGTTTCAAATAGTCCAGAAAATTTGAGTGCTTATTTAGATTATAAGAAAGCTGTAAGATATGATTATATTCTCAAAGTAGATTTAATACTATATAACAATATTTTGCGAAGTGTGAAATATGCCACAAAAGAATATAGAAATAATTAAACTGAGAGGAAATGTTTTAATGTTTATTTTAATTTTTTATACAAAAATGTTGACAAAATTATATGATAGTTATAATATAAGTATACATAAAGATATATATTAACGTAGAGTTACTATATATCTTTATGTAGAAAATCAAGAGCCGACTAATTTCTTGATTAAAATTAATTAATATATTAAAGTTGTTAAAATTATATAAGTTATTATACTGAAAATTATATATGAATTTATAATTTCTGTGGAAGAGAAATTATAAATTATTGTAATATTATTACAGCAACTATTTTATTATAAATGTGATAATTGTTAAGATAGCTACTATAATTGTTAAGATATTGGCAATTATAGTTAAGTTTATTTTTTTCATACTATCATCACCTTTCTATAAGAAAATGTTCCAGTATGAATGCTTATTAATTTTAACAACAATTATGTTATACTATATTTTCTAAAAAATCAAGTTACGTTAATATTTATATTTTAGTAATCATATTAATCTTTCTAGTATTAATATATTGTGGAACTTATAAAACTATAGGTTCTTTTTTTATGAGTAATTATATTTTTAATATACCAGTACTATCCTTAGGTATTATTCTATAATATGCTTAACAAAGAAAAATATTTTCTATTAATTAGGAGTTTAATTCCTAAGTTTTATTATTGAATTGTCTCCTGAAAAATATTCTATTTAATATCTTTTAAATGCTATTCCTCAAATTAATGCACTATATGCATTGTTCTCATTTATAATTATATTATAACCTATCTCAAAGATGTATCTCAATTAATTTAGCTTTATGATAGCATATATACTATTATTAATCAATTTACGATAATTAATATATTTTAATATATTTTGCGATTAAAATATATTAATTATAATATAACGATGTTTTTCAATAAATACAAAAAATAATATAATTATTAAGATTTGTAGTATAATAAAGACATATAAGAGAGATAATGGAGATGGTTATATGGGATTTAGATTTAGAAAATCAATTAAGATTTTACCTGGAGTTAAATTAAATATTGGTAAAAAGGGCATAAACTCTGTTTCTGTAGGTGGACATGGATTTACTAAAAATATAAGTAAAAATGGAACTAGAACTACTGTAGGAATACCTGGTAGTGGAATTAGTTATACAGACTATAAAAAGAAAGATACTAAAAAACAACCCAAAAAGAAAGATGGACTAGATTTTTCTCAAAAAGTAGCAGGAAAAATAGTTAATGCTGAATTGAATTTTCAAGAAGTGCCTTTTGAAATGGAAAAGATACCATTCTTTAGTAAAGCAATGAAGGTTGAATTAGCAGCAACTATATTATTTTGCTTACTTGGAATTGTTCAAATTGCTATGATTGTTTTTGCAATGCCATTTTTATTAGCATTATTGTTTAGCATGATATTTAATAAGAGAGCTAAAGCAAATACAGCACAGTTTTATGGTATCAAGAATTATAAGCTTAGTAAATGGCAGGAATGCGTAGATTATTGTAATAAAAGCCTAAAATTAGTTTATAATGAGAGTACAGAAAAACTTAGAAATTTAGCACAAGAAAAGATTGACACTGGATTCAAAAATAAGCAATTTAGTGATAAAGAAATAAAAGATATATTAGATAAGGCTTAAATAGTAGCCTTATTTTTTTTATGTAAAAGTAGGTGATTATATGATATGGATTAATATTTGGTTTACAATATGGCTTTTATATTTAGTTTATCAAAATAGGAATTTTTATATTGAATTAATAAATAACTGTTGTAAAAGACATGGTTATAGTAATTTAATAGATTTTATTTTAGGACGAAAAAGTCCATATTTAATATTTAATAAGAAGAATAGAAAATGAGTAGATCACTTGATTCAAACAAATTAAAAAATAGAAAATTTATATCAATTTCTTCAAAAGAAGCATTAAAAGAAGTAATCCCTATAGATTGGAGTGAAGATGTATTAACTGGTAAGAAAAAAGTTATTGTAAACAAATTAGAAGGAATGGTGATTAATGATGAATATAAATGATTTAGAAAGAGTTAGTTATAAAATAAAGGATTATAATGATTTACTTGAATATTATAAAAATATGGGTGAGTTTATTAATACACATGGAAATATATTTACAATAGAGGAACAGATTAATTTCTTAAAAGATTACAATAAATTTGTAGATGAATTTAATAAGTTTACTAAAGATTATCAACTGGAATTATATGTAATGTATTTAATTGGAGGGATGATTTAAATGGAAATAAAAATAAATATTGATGCTGGAGAAGTATTGGAAGTGTTGGAGAATATAAAGAATGAAATTAAAAGTTTGGAAGATATGAAAGTAGAAACTAAAAAGAATGATGACTTAGATTATACATGTAATATAAAGATGGATGCTATTAATCCAAATGAATTATTAGCGCCAATAGGAAGAGAACTGACTAAGAAAATTTTAAAAGAACTGAATGAATAGATATGGCATTGAAGAAACTATGCAGTGGATGTGGTAAGATCATAGACTACAATCTTAAAAGATGTGAGGAATGTGAGAAGAAATACAAAGTAGATAAGGCAGAGAAGAACAGGACATATGATAAGAATGTAAGGCAATTAAGAGATAGGAAGTATACATCATTCTATCATTCAAAGGAATGGATTAAGACAGTAGATATAGTTAAAAGTAAGTGTAAAGGACTAGATATATATAGTTACTATATACTTAATAAGATCGAGTATGGTAACATATGTCATCATATAAGACCATTAAAGATAGATGGTTGGGATGATAGATGTAATGTATGTAGGATAGTGTATCTTACTTATAGTAACCATAAGTTAGTACATGGTATGCTGAATGATAACTATGAAGATACAGTACATATGATGATTGGTTTGGTAGATAGATGGAAGAGAGAATATGAAGGTATATTAAGGGATACTGGTATATAGTCTTAATATTAATACTAGTTTTATTGTATTAATATATGCTATATATTTTTTTTACAAAGGTTAAAGAAGTCAAAGTATATATGGTAGGGGTATGAGAAAAGTTTCGACAAATTTCACATTGACCGCATCCCAACTTTCCGTCAAACAAATTTCCGAAATGACAAGTTAAAATCAAATAACAATCATTATCAATTAGAAAGAGGAGGTGTTTATAATGGCATTATCTGCAAAACCTGTAGATTTACAAAGGTCACATTTAACAAAACAAGAAATTACAGAGAGAAAAGAAGAGGAGCAAAAATTAAAAGGTAATAATAATAAAGTTTATAAAGCACCTTCTTATCTTTCTAAGGAAGAAAAGAAATTATATAAATTCATAGTAAAAGAATTAGAAGCCAGTAATATATTAAATAATTTAGATATAACTATTTTAGAAACAACAGTAGATGCAATAGTAAAGATGAAAGAATGTAAAAAAATATTAGATGAGCATGGACTAGTGACACCTAAAGAAGATGGCACGTTGAGTAGAAATCCTGCAAGTTTAATTTACAAAGATTATGTGAATATATTTAATAAGTGTTGCAATGAGTTAGGTCTTTCTCCATCTTCAAGGGCAAAATTAAGCGTAATAAATGTTAATGCAAAATCTACAAAAGAAGATCCAGTTTTACAAGCTCTAAGAGATGATGATAAATGATTCTATTAGATAAAGCCTTACAATATTGTAAAGATGTAATGGAAGGTAAAGAAATTACAACATGGGAAGTTAAAAGACAATGTGAAATATTCTTAGAAGATTATAATACTAATCAATATAGAGAAGATTTTAAATATTATGCAGATGAAAAACAACTTAAAAAAATAAATAATTTATTGAAATTATTGAATTACGCTACGGGATTTGTAGCTGGAAAACAAGTATTAAAATATTTAGTTGGTTTCCAATGCTTTTTAGTATGTGGTGTATTTTTGTTCAGATATAAAGATAATCCACATAAATTTATGCATAATGACATAACTCTCTTCATGAGTCGTAAAAATGCAAAAACAAATTTGGTGGCTATTATATTTATATTGCTTATGCTAACAGAACAAAACTATTCAGAATTTTATTCTATATGTTTAACAAGGGAACTTGCAGCAGAATTAAGAAAGGCAATGGTACAAGTATTAGAAGCAAGTCCTTTAATATTAAAACATTTTACAATTAGTAAAACATTCACTGGAAAAATAGAATGTAAATTAACACATAACTTTTTTCAGCCGAGAACTTCAGAACCAGGTAAGAACAATTCTGTACGACCTTCAGCAATGGTAGGAGATGAATTTGCTAATTTTCAGAATGCAGATAATTTTAACGCATTGCGAGGTGGAATGAAGAATGTTATCAATCCTGTAGTTTTCCGTACCACAACAGCATATGCAATAACTAATTCTATTATGGAAGAAGAAATTGATTATATTAGAAAAGTATTTAATGGTGTTGTAGATGATGAAAGACAATTTGCACTGCTATATTATGCAGAAGAAAAACATTTATGGGATGATACGGGTATATATCAGAGTAATCCACTAAGGATTAAAGAAAATTATAATATTATTAGAGATAATAGGAAGAAAGCATTATTAAAACCAACAGAAAAGATTGAATATATAACTAAAGATATGAATAATTTTCTACAAAATGCTAGTGAACATACATATTTAGACGTGAAAGAATGGAAAAAACATTCTGTTCCTAAGATAGATTTGAAGGGTAAAGAGGTTGTTGTAGGTGGAGATTTTGCAATTTCATTAGATTTAAATGGTATATCTATAATGTATAAGGAAAATGGTAAGTATTATTTAATGTCTAAAGGATTTTTACCCAAAGATACATTACCTGAACGTAGAGAAAAAATTGATTATGTACAGTATGAACAAGATGGATATTGTGAATTAATGGAAGGTAGAATTGCTGATTATAACAGAATAGAGGAATATATAAGAAACATTGAGCCTATGTATAATTGTAAAATTAAATGCATAGTATCTGATCCTTATAATGCCTTGCAGATGATGAACAATCTAGCAAAAAATTATGATGTAATTTTATTAAAACAATCTTTTAGTGCTTTAAGTCCAAGCATCAAAAATTTTAGAGATAGTGTTTATAATGGGGAAATAGTTTATCAGGAAAATAAGTTGTTAGATTATTGTGTCAGTAATGCTGTAGAGCATAGAGCAAAAATTACAGAAGATATTTTGCTCGCAAAAGAAGATAAAAATAAAAACAGAATAGATTTACTTATGAGTTCAATTTTTGCTTATAGTCAATTATGGATGGTAGAAGATAAAATAGAACTTACAGATGAGTATATTAAAAGTTTTTATTCTTAAAGTGGGGAGTGAATATGAAATATATAGCTATAATAAATAGAATTAAAGCAAAAAAAGCAACAATAAACAACTATATACATAATAAATTTAATAAAATAAAGCAGTTTATAAGCCAAAATATAGAAGATATATTAATATTTTTAGGCTTATTTTTTATTTTATATGCTACTTTTCTAATAAATTATATAGCATTTTTATATATTTTAGGCTTTATTTTATTAGGAATTGGTGTATTTTTAATAAAATTTCCTAAGAAATGATAGAGGAGGGAGGTGAAAATATAGAATATGGGATTATTTAAAAGTAGATTACAGAGTAAAGATATAAAAGATACAACATATGGTTTATCTGATCCTGGATTATTAAGTTTATTGGGAATAGATAGTGCTACAATAAATTCAGACAAGTTGGGAGAGATAGTATTCTTTACATGCCTACAAACTCTATCTAATTCTGTTAGTAAATTACCAATATATTTATATTCTTATAATGCTATAAAAGGAAAAGAGAGAATTATAGATAATAATTTAAATTACATTTTAAATATAGAACCAAATGAATACATGAGTGCAAGTACATTCTGGTCTTGTGTAGAATTAAACCGTAATTTTTATGGCAATTGTTATGTGTATGTTAACAGAGATAATAAAGGTAATATAAATTTTTTATGGATACTTGATACCGAAAATGTAACTGTTTGGAGAGATAGTGCAGGATTATTTGGACAGCAAAATGCCATGTGGTATGTTTGGTATGATAAAAATAATAGTGGTAAAAAGTATCTTTTTAGTGCAGATGAAATATTACATTATAAAACAGCCATAACATGGGATGGAATAATAGGAATGGCTGTAAAAGACATATTATCACAGCAAATAGACACACAAAAATATGGAGAAGGATATATTAATAACCTTTATAAGAACAATATGTTTGGGGATAAAGTTTTACTCCAATATACAGGAGATTTAGGAACAAAAGCTAAAGATACTTTAGTGAAGGAGACAGAAAAATATTGTAATTCTAATGGAACAAGGTTTTTGCCAATTCCTGCAACTATAGAAGCAAAGACATTATCAATGAAATTATCAGAAGCTGAATTCTCTACTATAAATAACACAAATGCTTTAAGAATTGCAGCAGCGTTTGGATTAAATCCAAATACCATCAATGATTATGGTAAGTCTTCCTATGCTAATTCCGTTAGTCAGCAAACAGATTTTTATGTTAATACATTATCTCCTATTTTAAATATGTATAAGCAAGAGAATACCAGAAAATTATTATTATTTAAAGATAAAATGAATGGAAATTTTCTTGAACATTACACTAAGGAAATATTTAAATTAGATCCAACAGCACAAATGGATTATTTAACAAAAGGTGTAAACAACATGATTATCAGACCAAATGAAGCTAGAGAAGAATTAGGTTATAGTTGGGCAGACAATGGTGACACATTAATAGGCAATGGAAACTTGGTTACATTGGATAATATAATAAGTGGTAAAACTAATACTCAACCAAGTAATGATACCAATATAGATAATAATTCCAATGATGATGGAGGTGAACAAAATAATAATGAGAAATAAAAAATTTTATGAATTTAAAAATGTAGGAAATGAAAGTTTAGACATTATGGTATATGGAGAAATAGTTTCTGGTGGACAAGATAGTAAATGGGATAGTACAGATGTATGTTTCCAAGATTTTAAGGATACTTTAGATAATTTAGGTAATACAAAAACTGTAAATTTATATATTAATAGCGTAGGGGGAAGTGTAATAACTACACAGGGAATTATTGCTATGTTACAAAGAGTAAAAGACAAAGGTGTGGTAGTTAATAGTTATATAGATGGACTTGGAGCCTCTTGTGCAAGTTTTCTTCCAATGATTTCTGATAATATATATGCTTATAATTCTAGTATTCTCATGATACATAAACCGATGAATATTGTAATGGGAAACGCTGATGATATGCAATCTCAAATTGATATACTAAATAAATTTGAAGATTCTGTAATGTTGCCTTTATATATGAGCAAAGCCAAAGATGGAGTTACAGATGAACAAATAAAAGATATGTTAAGCAAAGAAACATGGATGGATGCAACAGAAATGAGTAACATATTTGATATTACTATCTTAGAAGATGACAAAGACTTGACAGCCTGTATAAATGATGAAAGTATCCTTGATAATTATAAAAATATACCTAAATCTCTAAAAGATATATTAATGAAAGAATCTAAAGTAATTGAAAAAGTAAAAGATAAAGCTGAAGAGGAGAGACTAAAACAAATACAAGATAATAAAGATAAAGAAAAACAGGAGCTAGAATTATTAAAAGCAAAATTGTTATTAGAACTAGAGTGATAGTTCTTTTTTATGTCCAAAAATAAAAAATAAAATTAAAAGCGAGGTAAATTATATATGAAAAAATCAGACGAATTGAAAAAAGAATTACAAGAATTAAAGGATTCCGCAGAAAAATTAACTGTAGCAAAGGAAATAACAGATAAAATTGAAGAAATTAAAGCAGTAAAAGCTAAGATAACTTTAGCAGAAATGGAAGAAGCTGAAGCTAAAGCAGAAGCAGAAAGTAAGACTAAGGATGTTGAAGATAAAACTAAAAAAACTGAATTGAAAGATAAAAATTTAGGATTAATAGTTGCCAAGGCTATTGCAGGAAAAGAAATGACAGATGCAGAAGCTAAAGCATTTAAAGAAATTAGAAATACTGTAATCGAGGGAGATAGAACAAAGGGTGGAGTAGTAATTACACCAGATGTTTCTACAAAAATAATAGAATATCAGGATGCCACTAGAAATTTTGACATAAGACCATACATAAATGTAGAGCCAGTTGGAACTATGACAGGAACTAGACCAATAGCTAATAATATTCCACAAGCAGCAGGTTTTCCATCTTTAGATGAAGATGCAGAAATACAAGAAATGTATGAGCCAACATTTGAAGATATGAGTTATACAGTTCGTAAATATGGTGGATTTATACCTTTGACTTCAGAATTATTGGAGGATTCCGCAGAAAACATTCTAGCATTTATAACAAAATGGTTAGGTGAAAATGAGTTAAATACATATGCATACCAGATATTTAATGGAACAGGTGTAAAATCTGCACAAGGAATTATGACAGAAGCAAAAGTAGGTGGAGCATTAGAGAGTAGATTAGAAAGTATAAATACAGCACCAGATATTAAGAAATTCAAACATATATTTAATGTAGATTTAGAAAGTGTCAGCAATGATAATTTAGTGATATTTACAAATTGTGAAGGTTACGATTATTTAGATTCATTGGAAGATGCACAAGGACATAGTTATTTACAGCCAGATGCAACAAAACAATCTGGATTTACTTTTCTTGGTAGGGAAATTGTAAAAGTTCCTAAGAAATTCCTTGCAGATGTAGTAACAGGTACAGGAGAAACAGCAGTAACACAAGTACCATTTATTATGGGATCTTTAACGGATTTATATACTATGTTTGATAGAAAAGTAATGTCTTTAGAATCATCTAATGTAGGTGGAGATGCTTGGAGAAAAGATAGAACAGAAGTTAAAGGTGTATTCAGATTTGATGGTAAACTTCTTAATAAAAATGCAATTAAAGTATTATTAGCTAAATTAGCTTAAAAAACTTTAATAAATAAGGGTAATTTATAAGACTTAATAGGTCTTTTTTTATTGCTCTTATTTATTTAGGAATAAAAAGGATGGTGATGTAATTGATAGTAAGTTTAGCAGAAGCAAAAGAATGGCTAACAGTAGATTATGATGATAAAGACAACGATATACAGCTATTATGTGATTCCGCAGAAGCTTATTTATTTAATGCAACTGGAATAACTTTCGATAATACTAATCCTTTAGCAAAATTATATTGTAGAGTACTTATAACAGACTGGTTCGATAATAATGGACTAATGACAGATAAAGTTAGCGAAAAAGCTAGATTTTCATTACAATCTATTATGCTACAATTGCAATACTCTTATACCGTAGATACTACTACCACTACTACGGGGGTATAACATGAGCAATTTAACAAGTAAATTAAAAAATAAACTAGATTTATATGGTAAAACAGGTACTAGAGATAAATTAGGAGCTAAAGTACCTACATATGGCAAGATTAAACCTATATTTTGCCAAATAATACCTGCTAGTTTAACAGGAAATACGCAAAGAACAGTGGCAGATACAGAGTATGCAAATGTAACTCATACATTAAGATGTAGAAAATTAAGCATAAAAAATTTATCTATAGATATGTATTTTAAAGATAAAGATGGTTTGAGATATAATATTTTATATTTTCAACCAGATTATCAAGATAACCAGTTTTGGGAAGTAATGTTGGAAATTAAGTATGAATAAGAGGTGATATTGTATGGAAGATGGTTTTGACACACATGAATTAGATGAATTTAGTAAATCTTTACTTGATTTAGCTGAACAAAAACTACCTAAAGAGTCAAAAAAATACCTAAAAAAAGAAGCCAATAAATTAAAAACAAAGATGAAAAAGAAAGCAAAAGAAGTTGGTATACCCGATAAAGGTAATACAAATTTTTATAATAAATTTAAAGCTGGAAAAGTTTATAACTATCAGGGTGAAATGAGCGTAAGGGCATTTAATTCTAGTCCAATAGCACACCTTTTGGAGAATGGACATAAGCAAATAGGACATAAGCCAGATAAAAAGGATACTGGGAAATTTGTAAAAGGTTATGCTTATACAGAAAAAGCTTATCAAGATTTTAAAGAATCTTACTATTCTGACACAGAGGACTGGATAGATAAGATGTTAAAGGAAAAGGGATTATGATTACAGTTGCAGACGTGGTAACACAAATAAATACAATGCTTACAACAAAATTTCCTAGCACAAATATAACTTTTACAGATAATCCAGATGGACACGAAAGAGCTGCTTTTTATACAACAATTTTAAGTAATGCAAGTAACCAGCTATCAGATAGAAGGACACAAAAGAAAATAGGAATAAAAATATATTATTTTCCAAGTGATGAATATGATTATTTAGAAGAATTATGTAATATACAAAATGATATTGATGAATTATTTTGTCAGGGGTTTCCGTTACAAGACATTTATATAAATCTTGATGAGGACGGGATTGATTACAATATTACAGATGGAATATTACAAATATTATTTTATGTAAATTATTATATCGAAAGAGATACAGAAGAGGATAATTTGGATTATATCGAAAATATCGAAGATGAAGAAAATTATAAATAGAAAGGATTTGATATAGATGGCAATAACAAAGCCAGTTATAGATATACAATTTAAGGTATTAGCAAATACTTTTGTCGAAAGAAGTTCAAACAAAAAAGTTATTTTGATAATAAAAGATGATACAAATAAAGCTTTTAGTAAAAAAATATATACACAATTATCTGATGTAATAGCAGATAATGCATTATACACCATAGATAATTTAAACGCTCTTAAAGATTGCTTTAAGAAAAATATAAATCAGTTAACAGTAATAAGAATAGATGATGATGGAGCAATTGCAGACGCATTAGCAATAGCAGGAAGTTGTGAAACACAAAGTTATATAGGAGTGTATTCTAGTACAGCAGCAGATCACACCGCCTTGTCTGCATGGATAAAAACACAAGAAGCATCTAAGAAATATTACAATGCAATATGTTACAATTTAACAACCTCCGCAGATAGTAGGCATGTGATTAATTTTATAAATTCTAAAGTGAAATTTCTAGATTCTACAAGAGGAGAAGTAACAGGAGATAAATATATTCCAAGTTTATTGAGTTCAATAGCTGGAAGGAATGTAGAAACAGATGGTGTAACCTATGATATAATGGACGATTTGGAAAGTGTTACAGAAGTTGCAGATGTAGATACAGCAACAACTAATGGACAACTTGTATTATTCAATGATGGTGATAAAGTTAGAATATTAGTTGGTATAAATAATAAAACTACAGTTGGGACAGATGAAATAGAAGATATGAAACTTATTGAATATTCTGAAGCAATGGATATGATTTATTATGATGTTTACAATACATATAAAGATTTTTATCTATCTAAGTTTAAAAACTCCAATGATAATAGAGAAATTTTTGTAGATGCTGTTAATACTTATTATGGAGATTTAGAGGATTTAGACATTTTGAATCCTGATTTTGATAATATATGTACACAAAATGTAGGTACAATGAGGAATTATTTGAAACAAAATACTTCTTTAATTGTAGATAATATGACAGATGCACAAGTTAAACAGCAAAATTTTAGAAGAAATATATTTACAAGCTCTAATTTAGAAATATTAGAAAGTATGACAAATTTGTCGATGGAAAATATACTTAACTAA

Protein sequences of DBSCAN-SWA_2

>NC_022592|4038285:4066447|4058346_4060032_+|WP_023163403.1|terminase|DBSCAN-SWA
MILLDKALQYCKDVMEGKEITTWEVKRQCEIFLEDYNTNQYREDFKYYADEKQLKKINNLLKLLNYATGFVAGKQVLKYLVGFQCFLVCGVFLFRYKDNPHKFMHNDITLFMSRKNAKTNLVAIIFILLMLTEQNYSEFYSICLTRELAAELRKAMVQVLEASPLILKHFTISKTFTGKIECKLTHNFFQPRTSEPGKNNSVRPSAMVGDEFANFQNADNFNALRGGMKNVINPVVFRTTTAYAITNSIMEEEIDYIRKVFNGVVDDERQFALLYYAEEKHLWDDTGIYQSNPLRIKENYNIIRDNRKKALLKPTEKIEYITKDMNNFLQNASEHTYLDVKEWKKHSVPKIDLKGKEVVVGGDFAISLDLNGISIMYKENGKYYLMSKGFLPKDTLPERREKIDYVQYEQDGYCELMEGRIADYNRIEEYIRNIEPMYNCKIKCIVSDPYNALQMMNNLAKNYDVILLKQSFSALSPSIKNFRDSVYNGEIVYQENKLLDYCVSNAVEHRAKITEDILLAKEDKNKNRIDLLMSSIFAYSQLWMVEDKIELTDEYIKSFYS
>NC_022592|4038285:4066447|4046717_4047059_+|WP_023163389.1|DBSCAN-SWA
MEMTNIKNYSSEDEERQIFNSIVKNAVERNLGEIKGQDVILHYSGDMDCILNIENTHVATVACKDRKIHYIRLYGDNEQEVDIDVDKINSIQNEIDMIDFYMQNNNLITIELQ
>NC_022592|4038285:4066447|4057864_4058350_+|WP_023163402.1|terminase|DBSCAN-SWA
MALSAKPVDLQRSHLTKQEITERKEEEQKLKGNNNKVYKAPSYLSKEEKKLYKFIVKELEASNILNNLDITILETTVDAIVKMKECKKILDEHGLVTPKEDGTLSRNPASLIYKDYVNIFNKCCNELGLSPSSRAKLSVINVNAKSTKEDPVLQALRDDDK
>NC_022592|4038285:4066447|4055682_4056339_+|WP_023163396.1|DBSCAN-SWA
MGFRFRKSIKILPGVKLNIGKKGINSVSVGGHGFTKNISKNGTRTTVGIPGSGISYTDYKKKDTKKQPKKKDGLDFSQKVAGKIVNAELNFQEVPFEMEKIPFFSKAMKVELAATILFCLLGIVQIAMIVFAMPFLLALLFSMIFNKRAKANTAQFYGIKNYKLSKWQECVDYCNKSLKLVYNESTEKLRNLAQEKIDTGFKNKQFSDKEIKDILDKA
>NC_022592|4038285:4066447|4049990_4052729_+|WP_023163392.1|DBSCAN-SWA
MLNKQVRMYCVKLNLVRTEEEKYMCLQRIRMEQIRFFLKKHMSNIVRRELEVKNWTEECSKLFKEKINENKYYTYIESKLREIKKDIHKLYVANKDLDRSVKSKDIKTKDIIAIGDNNLVRVLGLNLGSFTDQIITVKVGDMDNIIVEKIVKDGLTIDKQHYIFFTAGAGQTRQKKFMMIKNDEALKDVMLTLMNGLTIEEINKKGGMNISKFLAYLSLNNSGSTVWENFDIDRCIVVADFETMVSAKVDYISRKTEKVEYRDKLDRKRTKDVANWTIDKNKTMDVPIPHFDGLGIMLPSIAQKNTQVRLPWIKGLLTPFNYIEYIKEKSYDTKITDIYGQEYDIIEDNIQIIFTKSQFKLTKYYNDWQEYKDNFHKYNCTANICMQDEEKSDKYKDMQINYQMLQQLINISDKQIELLCKDFKSLIRKVHTDRKSQLEFLSATKKNEHRNYFQEALRIYPEMLKSAYVNKKISKTITKAKNDACCGKIKIKNSKRIFILSDPIAFVDWLFGHIEVPEGYLKDGEVYCNLYKNDVKLDVLRSPSLSFEHVIRKNVRATKGKYKWFITNGIYTSTHDVISKTLAFDCDGDEALVLSTDWIISLAEEMIDIYDIHPIYFEMGKAPATQINKDNIVKSLIFVYKKSNIGKISNTLTRMWNSENPMDDYEIMQKLCAYNNDIIDSAKTLFLPKLPSDVNEFIKNDKYPYFFQYAKNKKELQCKPMSNSVMDRICKNIENIENTKFDYSKGFGIFRVKTLMFNQDNIEVNKDVIIKYLEIEKDTTDKIDEYSKEFTNEDEEDMKKTDFKEIFYGYARKEFETWGKENNIDILNIVDTLIKYTYKTNDLKMSFLWNVFGQEILNNINININKPLDNGYLMCEDCGKRVKRETNNQKRCPKCAKQKSHKKVKGDSKQVS
>NC_022592|4038285:4066447|4040973_4041141_+|WP_023163379.1|DBSCAN-SWA
MLEILDYYLFYSDRLLINFLIQHISAQQFFMGTLFVSLAMDCTLENSNKKKKVSK
>NC_022592|4038285:4066447|4065352_4066447_+|WP_023163412.1|DBSCAN-SWA
MAITKPVIDIQFKVLANTFVERSSNKKVILIIKDDTNKAFSKKIYTQLSDVIADNALYTIDNLNALKDCFKKNINQLTVIRIDDDGAIADALAIAGSCETQSYIGVYSSTAADHTALSAWIKTQEASKKYYNAICYNLTTSADSRHVINFINSKVKFLDSTRGEVTGDKYIPSLLSSIAGRNVETDGVTYDIMDDLESVTEVADVDTATTNGQLVLFNDGDKVRILVGINNKTTVGTDEIEDMKLIEYSEAMDMIYYDVYNTYKDFYLSKFKNSNDNREIFVDAVNTYYGDLEDLDILNPDFDNICTQNVGTMRNYLKQNTSLIVDNMTDAQVKQQNFRRNIFTSSNLEILESMTNLSMENILN
>NC_022592|4038285:4066447|4061616_4062414_+|WP_023163406.1|protease|DBSCAN-SWA
MRNKKFYEFKNVGNESLDIMVYGEIVSGGQDSKWDSTDVCFQDFKDTLDNLGNTKTVNLYINSVGGSVITTQGIIAMLQRVKDKGVVVNSYIDGLGASCASFLPMISDNIYAYNSSILMIHKPMNIVMGNADDMQSQIDILNKFEDSVMLPLYMSKAKDGVTDEQIKDMLSKETWMDATEMSNIFDITILEDDKDLTACINDESILDNYKNIPKSLKDILMKESKVIEKVKDKAEEERLKQIQDNKDKEKQELELLKAKLLLELE
>NC_022592|4038285:4066447|4060106_4060292_+|WP_029702297.1|DBSCAN-SWA
MHNKFNKIKQFISQNIEDILIFLGLFFILYATFLINYIAFLYILGFILLGIGVFLIKFPKK
>NC_022592|4038285:4066447|4039247_4039676_+|WP_023163376.1|DBSCAN-SWA
MINYTIIDNSTITYNISDNAYRIYNFLLSMCYNKDHCYPSQKYISERLCKSVRTVQRGIQECFKAGLILRIKRRGSISNVYTLLKTSTSNVVNTVKTTIDKVKKSYTKKKSLFNDFPQRKYDYKELEQQLLGNAVYDPKKLE
>NC_022592|4038285:4066447|4053270_4053540_+|WP_023163393.1|DBSCAN-SWA
MTNCKKMSNLNEYIIRNLHMEVMDSNIVPVKDEIAAWKDAKQDENVIKNLEKYIGYNCLYAIDTLNGLFKQGCVIIDDDMKYIGFVETV
>NC_022592|4038285:4066447|4064100_4064445_+|WP_023163409.1|head,tail|DBSCAN-SWA
MSNLTSKLKNKLDLYGKTGTRDKLGAKVPTYGKIKPIFCQIIPASLTGNTQRTVADTEYANVTHTLRCRKLSIKNLSIDMYFKDKDGLRYNILYFQPDYQDNQFWEVMLEIKYE
>NC_022592|4038285:4066447|4045131_4045620_+|WP_023163385.1|DBSCAN-SWA
MIINLKNISEKNIKNLLINGDKIVRNINRISKNTKNIIKLNGATYAKLNIDIKSYGSIFNFLNQNYKMNEYYTDEFIKYFIKFMFVNFNDVYYVVYGNISDPIDIKESKLMLTGMYLNKLYLTLTGHVFIEEPDFDMKVILTYTDNKLLIDKFDNWGINLID
>NC_022592|4038285:4066447|4040456_4040852_+|WP_023163378.1|DBSCAN-SWA
MVQKIIRLLLTKVIPSPTGSRYVEDILYNQRVYPIYSEVQQRLTYCLKNKLINRDELMTFKYMLNKYIRNSYAYKDKKWKNDAHEIFTKLKSHYIKTKEMKRLLKYVNQFYIDIPEPIQKFKTVSYLKVIK
>NC_022592|4038285:4066447|4056715_4056952_+|WP_023163399.1|DBSCAN-SWA
MMNINDLERVSYKIKDYNDLLEYYKNMGEFINTHGNIFTIEEQINFLKDYNKFVDEFNKFTKDYQLELYVMYLIGGMI
>NC_022592|4038285:4066447|4056952_4057174_+|WP_023163400.1|DBSCAN-SWA
MEIKINIDAGEVLEVLENIKNEIKSLEDMKVETKKNDDLDYTCNIKMDAINPNELLAPIGRELTKKILKELNE
>NC_022592|4038285:4066447|4062471_4063701_+|WP_023163407.1|capsid|DBSCAN-SWA
MKKSDELKKELQELKDSAEKLTVAKEITDKIEEIKAVKAKITLAEMEEAEAKAEAESKTKDVEDKTKKTELKDKNLGLIVAKAIAGKEMTDAEAKAFKEIRNTVIEGDRTKGGVVITPDVSTKIIEYQDATRNFDIRPYINVEPVGTMTGTRPIANNIPQAAGFPSLDEDAEIQEMYEPTFEDMSYTVRKYGGFIPLTSELLEDSAENILAFITKWLGENELNTYAYQIFNGTGVKSAQGIMTEAKVGGALESRLESINTAPDIKKFKHIFNVDLESVSNDNLVIFTNCEGYDYLDSLEDAQGHSYLQPDATKQSGFTFLGREIVKVPKKFLADVVTGTGETAVTQVPFIMGSLTDLYTMFDRKVMSLESSNVGGDAWRKDRTEVKGVFRFDGKLLNKNAIKVLLAKLA
>NC_022592|4038285:4066447|4042859_4043003_+|WP_158212040.1|DBSCAN-SWA
MKKLGEEIYPIVIIVRPVTTNSLVEDHTFSILYSDFELSNLAKVLNN
>NC_022592|4038285:4066447|4057176_4057650_+|WP_023163401.1|DBSCAN-SWA
MALKKLCSGCGKIIDYNLKRCEECEKKYKVDKAEKNRTYDKNVRQLRDRKYTSFYHSKEWIKTVDIVKSKCKGLDIYSYYILNKIEYGNICHHIRPLKIDGWDDRCNVCRIVYLTYSNHKLVHGMLNDNYEDTVHMMIGLVDRWKREYEGILRDTGI
>NC_022592|4038285:4066447|4044128_4044656_+|WP_023163383.1|DBSCAN-SWA
MENSQKELMKDFVIKNKFSCYNDDIKDMAIRKLQNEMKKEFFDDIIDYKIHNIKDIMTIFFKFNNNLGVNLHCNRIIYDTLRTHITFRYEIVCYCDKKNPIYSEVIRTFEYMKIERINEIFEFIKSLRIYFFDIDHRKYKYDGYGHFERKKKDMVKYIDKSIEEILMYGVVKNIN
>NC_022592|4038285:4066447|4047508_4048456_+|WP_023163390.1|DBSCAN-SWA
MIKYVNRTSKKLRQKVLDKALKEEMEYLRKRCFPWQKQPFLYNPVVVHEKVFLPDKEEGNTLGLYKYNEKENKHYVYVDKAHVWGVHKMPVSYLRQYYYKEVRGILRHELIHCFCQENWNYKYISFIKNMERDASPIFLAILYFCDGYTGHNCTKGWMQTELYKKIKQKYFKNYKQLEKYLEDMLWKFAIQINKIKEFTNEKNFKLGLDANYTKISNEFEFAPRNNGLTKFSEINFQDIFFSKYNKDLKNRRTIKNVSRIWEIGCNVDPNRLIELYNRKQYCEATYYNTKKRLIVPNAQITKPEKIINIKENKNF
>NC_022592|4038285:4066447|4041140_4042409_+|WP_023163380.1|DBSCAN-SWA
MFVEMGLIGGGWYCYDRIKNKDIYYVKSKIKKMFEKNNIDYYPIYKVNRKLPWGYEVLITLGEHGFNKLNNLQDEIQTSIGYPITIEQSLNYELGIIKVIVNPPNTETIFAPVKVKPYEIFVSLNNTNQNLIVNLQKFPHVLVSGQTGCGKTEEIRSILTNSIYFHTARDLNLYFADLSDMCDFDIFKNCKQTKAYVKNIEDSTKLFEYLMHIYTKRLQIFEKNNCKNIQEYNSRFYGKRMAYNFIVLDEFADYFPTTKLDKNYKQKVLCYNYLKEFARKFRKVGSFLICGIQRPDTTVLDPNLRSCLCTKIGFSQNSDASSLTVCDTAELTNIENRKGLLMYGNKREWFYSLAIDDNLIKENIKNSILENRGSYTDYNKFLNTNNNAVPMKTKKCEKDDNPGIKKDRPKTKTKLKVKKNVK
>NC_022592|4038285:4066447|4040101_4040314_+|WP_023163377.1|DBSCAN-SWA
MVKNRLKEIRMKEYMMNQKEFCEKVLNISRYTYNPIEGNKVQGNIETAMNIAKALKRKVEDIWYFDNEAK
>NC_022592|4038285:4066447|4054426_4054702_+|WP_023163395.1|DBSCAN-SWA
MEEDRKKHIRTKSLNAITYILYKNPLQDLEFWKDESNGQILFQVSNSPENLSAYLDYKKAVRYDYILKVDLILYNNILRSVKYATKEYRNN
>NC_022592|4038285:4066447|4044677_4044980_+|WP_023163384.1|DBSCAN-SWA
MFNDKMRLINETVFIDTIKKTSMCLKKSNDILENLKDGVTNNEYYNALYILDKTCKILENLSEMNFKEAKLYTKLMLHKSGNEEIENKVEDDNIKQFSKE
>NC_022592|4038285:4066447|4063793_4064099_+|WP_023163408.1|head,tail|DBSCAN-SWA
MIVSLAEAKEWLTVDYDDKDNDIQLLCDSAEAYLFNATGITFDNTNPLAKLYCRVLITDWFDNNGLMTDKVSEKARFSLQSIMLQLQYSYTVDTTTTTTGV
>NC_022592|4038285:4066447|4038285_4039248_+|WP_023163375.1|integrase|DBSCAN-SWA
MAKLKLKNIKKTTNKNIREIYKDYLEYCISIGQREMTIKSKQRYGTYVLNKVVNLEDKIETLTKDKIENYVNKMRREGYKGNTYQSFVIKTRAFLTYCFNQNYLKKFDVKIPNILLEKKQIYMEEEILKLLKKPNINDCLVGDFRSWAEISFLLGTGCRAETLLNVHVEDIDFNTDSILFRHMKTKRQITVPLSNTLKVTLIEYIQRTGLKKEDYLFPLLNGEKMSYDTCHQNLLNYFKHRKIKFHGVNTFRNTFATMFIKNGGDIYRLKIILGHSEIKTTERYINLLPLQVKNDIQKFNPLDVLSKKNIRMSVKRGGRR
>NC_022592|4038285:4066447|4046097_4046400_+|WP_023163387.1|DBSCAN-SWA
MVYYHFTPIDNLPSILKSRTLVNKSNGVFVCDSFEDLCKFVTIYRNLNGYKLDDLAYISFETDMELEESFDHDKEFFNGARAYYSLDDIEMENICVSLFS
>NC_022592|4038285:4066447|4053709_4054330_+|WP_023163394.1|DBSCAN-SWA
MLIKQGKINKCGIYGIKTNQGKILYVGGAKECNDAYSRHRTNLINGAYCETNKDELQTIFNTEQDDLIFYVIEECKENELDKEETKYIELYSKTIINSDMKGKRRKNKSTPEETKHRRQANEGENNPHNTKLSEEDVFDILDMLKNGVNRDIIENKYDICKGYTYRIGCDRWVKTYNKWKIKKEASTAIDTSNICTSANVQFVSYN
>NC_022592|4038285:4066447|4064892_4065336_+|WP_023163411.1|DBSCAN-SWA
MITVADVVTQINTMLTTKFPSTNITFTDNPDGHERAAFYTTILSNASNQLSDRRTQKKIGIKIYYFPSDEYDYLEELCNIQNDIDELFCQGFPLQDIYINLDEDGIDYNITDGILQILFYVNYYIERDTEEDNLDYIENIEDEENYK
>NC_022592|4038285:4066447|4048474_4049620_+|WP_023163391.1|DBSCAN-SWA
MNIKSIKVGQVIKNYKELCLLMEEKVSAGDTKKKQLKEWARYFKWHKEGQKFIIDEIYKDPLPKQDRRKNNSHSKYIEEIKDILTYYIHGQIQRTGNNVVTLSISELINICGFANNTYSLSTYKKKELSDILHIELVAIYNFYSSTRTEFKRIIERALKNLKSRSVLIYQDTFIVANVDKGHNKVDKRPATDEEYNLILDTQNEMLKHYNMESFKDLFLAGKKVYKSFMNDVNKELEWDFYYPAYKIICGKNAVKREYKKIIDKKKQLNDKSIERCKNLFKIVDDNSNENKLINNLISFKNYNPNIDDLIQIQYQKNKHEYFKKLNEENYRISKIEEDYKNKDDVSLSDLSKYKYKTKRHNDHEEYWSYLLNEIDTYNIQN
>NC_022592|4038285:4066447|4060319_4061627_+|WP_023163405.1|portal|DBSCAN-SWA
MGLFKSRLQSKDIKDTTYGLSDPGLLSLLGIDSATINSDKLGEIVFFTCLQTLSNSVSKLPIYLYSYNAIKGKERIIDNNLNYILNIEPNEYMSASTFWSCVELNRNFYGNCYVYVNRDNKGNINFLWILDTENVTVWRDSAGLFGQQNAMWYVWYDKNNSGKKYLFSADEILHYKTAITWDGIIGMAVKDILSQQIDTQKYGEGYINNLYKNNMFGDKVLLQYTGDLGTKAKDTLVKETEKYCNSNGTRFLPIPATIEAKTLSMKLSEAEFSTINNTNALRIAAAFGLNPNTINDYGKSSYANSVSQQTDFYVNTLSPILNMYKQENTRKLLLFKDKMNGNFLEHYTKEIFKLDPTAQMDYLTKGVNNMIIRPNEAREELGYSWADNGDTLIGNGNLVTLDNIISGKTNTQPSNDTNIDNNSNDDGGEQNNNEK
>NC_022592|4038285:4066447|4043205_4043826_+|WP_023163382.1|DBSCAN-SWA
MFLVDILFFIIDNFTLILIGIGLIIIIYSWITIFVNKDYEFIADYSRKYKNRVLTIKDLDKIKHEIEYMEGRQFERFSEWLFKNIGKYKKVTLTPAANDEGRDLILIDDDDNTIFVECKRYTENATVTEDFMIGREICQKLVGAMVADTIKRGIIITTGNIHQNAWDYIVKLEKNSDIRIEIITLDDIMRMIKKINSPEVLNVVGA
>NC_022592|4038285:4066447|4056555_4056732_+|WP_023163398.1|DBSCAN-SWA
MSRSLDSNKLKNRKFISISSKEALKEVIPIDWSEDVLTGKKKVIVNKLEGMVINDEYK
>NC_022592|4038285:4066447|4046511_4046691_+|WP_023163388.1|DBSCAN-SWA
MSNVLEIKQQQLQEKIGQIVPWDYVPKENIEHVFTVYISGNMPIKIKSSLTYKQFCKIC
>NC_022592|4038285:4066447|4045644_4045869_-|WP_023163386.1|DBSCAN-SWA
MIHIKINEQLKKQGKTIYWLSKECKCNYANLKKLAANNTDSIKFSLLEIICEVLKCDLSDVMEIIKDNEEKVKE
>NC_022592|4038285:4066447|4064458_4064896_+|WP_023163410.1|DBSCAN-SWA
MEDGFDTHELDEFSKSLLDLAEQKLPKESKKYLKKEANKLKTKMKKKAKEVGIPDKGNTNFYNKFKAGKVYNYQGEMSVRAFNSSPIAHLLENGHKQIGHKPDKKDTGKFVKGYAYTEKAYQDFKESYYSDTEDWIDKMLKEKGL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
4029867:4029883	attL	NA	NA	NA	NA
WP_023163375.1|4038285_4039248_+|integrase	site-specific integrase	A0A1L4BKH1	Thermus_phage	5.4e-09	23.7
WP_023163376.1|4039247_4039676_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_023163377.1|4040101_4040314_+	transcriptional regulator	A0A2H4J765	uncultured_Caudovirales_phage	7.1e-15	65.2
WP_023163378.1|4040456_4040852_+	hypothetical protein	NA	NA	NA	NA
WP_023163379.1|4040973_4041141_+	hypothetical protein	NA	NA	NA	NA
WP_023163380.1|4041140_4042409_+	cell division FtsK/SpoIIIE	NA	NA	NA	NA
WP_158212040.1|4042859_4043003_+	hypothetical protein	NA	NA	NA	NA
WP_023163382.1|4043205_4043826_+	restriction endonuclease	NA	NA	NA	NA
WP_023163383.1|4044128_4044656_+	hypothetical protein	NA	NA	NA	NA
WP_023163384.1|4044677_4044980_+	hypothetical protein	NA	NA	NA	NA
WP_023163385.1|4045131_4045620_+	hypothetical protein	NA	NA	NA	NA
WP_023163386.1|4045644_4045869_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_023163387.1|4046097_4046400_+	hypothetical protein	NA	NA	NA	NA
WP_023163388.1|4046511_4046691_+	hypothetical protein	NA	NA	NA	NA
WP_023163389.1|4046717_4047059_+	hypothetical protein	NA	NA	NA	NA
WP_023163390.1|4047508_4048456_+	hypothetical protein	NA	NA	NA	NA
WP_023163391.1|4048474_4049620_+	hypothetical protein	NA	NA	NA	NA
WP_023163392.1|4049990_4052729_+	RNA-dependent RNA polymerase	O64076	Bacillus_phage	3.6e-127	35.3
WP_023163393.1|4053270_4053540_+	hypothetical protein	NA	NA	NA	NA
WP_023163394.1|4053709_4054330_+	Excinuclease ABC C subunit domain protein	NA	NA	NA	NA
WP_023163395.1|4054426_4054702_+	hypothetical protein	NA	NA	NA	NA
WP_023163396.1|4055682_4056339_+	DUF4236 domain-containing protein	NA	NA	NA	NA
WP_023163398.1|4056555_4056732_+	hypothetical protein	NA	NA	NA	NA
WP_023163399.1|4056715_4056952_+	hypothetical protein	NA	NA	NA	NA
WP_023163400.1|4056952_4057174_+	hypothetical protein	NA	NA	NA	NA
WP_023163401.1|4057176_4057650_+	hypothetical protein	NA	NA	NA	NA
WP_023163402.1|4057864_4058350_+|terminase	phage terminase small subunit P27 family	A0A0A7RUQ4	Clostridium_phage	7.6e-20	41.0
WP_023163403.1|4058346_4060032_+|terminase	terminase	A0A0A7RUM0	Clostridium_phage	2.8e-202	61.4
WP_029702297.1|4060106_4060292_+	hypothetical protein	NA	NA	NA	NA
WP_023163405.1|4060319_4061627_+|portal	phage portal protein	A6M949	Geobacillus_virus	2.0e-75	40.3
WP_023163406.1|4061616_4062414_+|protease	Clp protease ClpP	A0A0A7RUD3	Clostridium_phage	2.0e-78	60.4
WP_023163407.1|4062471_4063701_+|capsid	phage major capsid protein	A0A2I7SBY4	Paenibacillus_phage	3.7e-31	32.1
WP_023163408.1|4063793_4064099_+|head,tail	phage gp6-like head-tail connector protein	A0A0A7RWM0	Clostridium_phage	8.7e-22	55.8
WP_023163409.1|4064100_4064445_+|head,tail	head-tail adaptor protein	NA	NA	NA	NA
WP_023163410.1|4064458_4064896_+	HK97 gp10 family phage protein	NA	NA	NA	NA
WP_023163411.1|4064892_4065336_+	hypothetical protein	NA	NA	NA	NA
4065242:4065258	attR	NA	NA	NA	NA
WP_023163412.1|4065352_4066447_+	hypothetical protein	A0A090D804	Clostridium_phage	2.2e-22	27.6