CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022600	Gloeobacter kilaueensis JS1, complete sequence	9 crisprs	WYL,Cas14c_CAS-V-F,c2c9_V-U4,cas3,Cas14u_CAS-V,cas4,cas10d,csc2gr7,csc1gr5,cas6,cas1,cas2,csa3,DinG,2OG_CAS,csx3,cas10,csm3gr7,csx19,csm6,cas3HD,Cas9_archaeal,cmr3gr5,cmr4gr7,cmr5gr11,csx1,csx18	1	8	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022600_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022600_1

1267717-1267798

Orphan

Consensus_repeat	Method
CTGGACCGGCAGGACCACCTCGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022600_1

>merge|NC_022600|1|1267717-1267798|CRISPRCasFinder
CTGGACCGGCAGGACCACCTCGGCGAGGGTGCGGGCCGCCGCGCCGCTTATCGCTCCCTGGACCGGCAGGACCACCTCGCGG

>NC_022600|1|1|1267717-1267798|CRISPRCasFinder
CTGGACCGGCAGGACCACCTCGGCG	AGGGTGCGGGCCGCCGCGCCGCTTATCGCTCC
CTGGACCGGCAGGACCACCTCGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022600.1\|WP_023172573.1\|1259660_1260230_+\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023172576.1\|1262514_1263060_-\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238496
NC_022600.1\|WP_023172575.1\|1261785_1262424_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NC_022600.1\|WP_023172589.1\|1276311_1276755_-\|DUF4079-domain-containing-protein	unknown	unknown	gnl\|CDD\|372553
NC_022600.1\|WP_023172586.1\|1273901_1274702_-\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851
NC_022600.1\|WP_023172577.1\|1263129_1264509_-\|phosphomethylpyrimidine-synthase-ThiC	unknown	unknown	gnl\|CDD\|237359
NC_022600.1\|WP_023172579.1\|1266537_1266900_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237019
NC_022600.1\|WP_023172584.1\|1271432_1272119_+\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023172574.1\|1260226_1261717_+\|type-II-and-III-secretion-system-protein	unknown	unknown	gnl\|CDD\|224367
NC_022600.1\|WP_023172572.1\|1258974_1259640_+\|type-4a-pilus-biogenesis-protein-PilO	unknown	unknown	unknown
NC_022600.1\|WP_023172585.1\|1272115_1273777_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023172570.1\|1257211_1258978_+\|type-IV-pilus-assembly-protein-PilM	unknown	unknown	gnl\|CDD\|227306
NC_022600.1\|WP_187293896.1\|1275757_1276165_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023172582.1\|1269243_1269837_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NC_022600.1\|WP_023172568.1\|1256362_1257190_+\|A24-family-peptidase	unknown	unknown	gnl\|CDD\|377700
NC_022600.1\|WP_144080332.1\|1269919_1271440_+\|SagB-family-peptide-dehydrogenase	unknown	unknown	gnl\|CDD\|380318
NC_022600.1\|WP_023172590.1\|1276803_1278156_-\|Ig-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379073
NC_022600.1\|WP_051382928.1\|1264733_1266185_+\|NADP-dependent-phosphogluconate-dehydrogenase	unknown	unknown	gnl\|CDD\|236453
NC_022600.1\|WP_023172581.1\|1268183_1269107_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_022600.1\|WP_023172587.1\|1274870_1275752_+\|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl\|CDD\|213022

Protein	Function_ID	Function_description	E-value
NC_022600.1\|WP_023172576.1\|1262514_1263060_-\|cysteine-hydrolase	gnl\|CDD\|238496	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.	1.03086e-58
NC_022600.1\|WP_023172575.1\|1261785_1262424_+\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	2.10104e-27
NC_022600.1\|WP_023172589.1\|1276311_1276755_-\|DUF4079-domain-containing-protein	gnl\|CDD\|372553	pfam13301, DUF4079, Protein of unknown function (DUF4079). This is an uncharacterized family of proteins.	1.89561e-25
NC_022600.1\|WP_023172577.1\|1263129_1264509_-\|phosphomethylpyrimidine-synthase-ThiC	gnl\|CDD\|237359	PRK13352, PRK13352, phosphomethylpyrimidine synthase ThiC.	0
NC_022600.1\|WP_144080332.1\|1269919_1271440_+\|SagB-family-peptide-dehydrogenase	gnl\|CDD\|380318	cd02142, McbC_SagB-like_oxidoreductase, oxidase similar to the microcin B17 processing protein McbC. This family is the oxidase domain of NRPS (non-ribosomal peptide synthetase) and other systems that modify polypeptides by cyclizing a thioester to form a ring. These include EpoB, part of the epothilone biosynthesis pathway; TubD, part of the tubulysin biosynthesis pathway, MtsD, part of the myxothiozol biosynthesis pathway; IndC, part of the indigoidine biosynthesis pathway and TfxB, part of the trifitoxin processing pathway. All are FMN-dependent and oxidize the product of the cyclization of thioesters in short polypeptides.	9.05686e-48
NC_022600.1\|WP_023172570.1\|1257211_1258978_+\|type-IV-pilus-assembly-protein-PilM	gnl\|CDD\|227306	COG4972, PilM, Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion].	7.02839e-68
NC_022600.1\|WP_023172574.1\|1260226_1261717_+\|type-II-and-III-secretion-system-protein	gnl\|CDD\|224367	COG1450, PulD, Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion].	1.41355e-42
NC_022600.1\|WP_023172586.1\|1273901_1274702_-\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	7.51907e-95
NC_022600.1\|WP_023172582.1\|1269243_1269837_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	2.19787e-34
NC_022600.1\|WP_023172568.1\|1256362_1257190_+\|A24-family-peptidase	gnl\|CDD\|377700	pfam06750, DiS_P_DiS, Bacterial Peptidase A24 N-terminal domain. This family is found at the N-terminus of the pre-pilin peptidases (pfam01478). It's function has not been specifically determined; however some of the family have been characterized as bifunctional, and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and two almost fully conserved disulphide bridges - hence the name DiS-P-DiS. The cysteines have been shown to be essential to the overall function of the enzyme in, but their role was incorrectly ascribed.	1.27598e-40
NC_022600.1\|WP_023172579.1\|1266537_1266900_+\|hypothetical-protein	gnl\|CDD\|237019	PRK11907, PRK11907, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	0.000140227
NC_022600.1\|WP_023172590.1\|1276803_1278156_-\|Ig-like-domain-containing-protein	gnl\|CDD\|379073	pfam13205, Big_5, Bacterial Ig-like domain.	0.000837
NC_022600.1\|WP_051382928.1\|1264733_1266185_+\|NADP-dependent-phosphogluconate-dehydrogenase	gnl\|CDD\|236453	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase.	0
NC_022600.1\|WP_023172581.1\|1268183_1269107_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	7.85886e-100
NC_022600.1\|WP_023172587.1\|1274870_1275752_+\|polysaccharide-deacetylase-family-protein	gnl\|CDD\|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	3.4989e-72

>NC_022600.1|WP_023172579.1|1266537_1266900_+|hypothetical-protein
METRNPQTRNRTESTSSSFSGAAIALAIVALLAVGLVAVFVFNGQSRSTSTSTTTSITTPAPAPSANPPSVTIQTPSAPSRSESSEAPASDTSNSGATDSGNSPSDPSGSGSANSSTQPQ
>NC_022600.1|WP_051382928.1|1264733_1266185_+|NADP-dependent-phosphogluconate-dehydrogenase
METSLRPSGTQAAHEKPSIGLVGLAVMGENLALNIANKGFGISVYNRTAAKTKELAEGRAQGKSLYPTYTIEEFVASMARPRKIIILVKAGAPVDAVIDQLKPLLEKDDVIIDGGNSLFTDTEKRSTQIEALGLRYVGMGVSGGEEGALKGPSLMPGGPRTAYDDLAPILSRIAAQVDDGPCVTYIGPRGAGHYVKMVHNGIEYGDMQLIAEAYDLLKQTLHLEAAELHDIFSEWNEGELKSFLIEITADIFTKLDPETGKPLVELILDKAGQKGTGKWTSQNAYDLGVPIPTINAAVESRILSAYKTERVAASKILSGPERPAFTGDKKQFIKAVRDALYSAKICSYAQGMALLKAASQEFKYELNLSECARIWKGGCIIRAVFLDKIKNAFLRDPALTNLLIDPDFSGDILDRQANWRSVVQTAAQLGIPAYATAASLAYYDAYRSAQLPLNLTQAQRDYFGAHTYERIDKEGVFHTEWLQ
>NC_022600.1|WP_023172577.1|1263129_1264509_-|phosphomethylpyrimidine-synthase-ThiC
MLRTDWIARRHGQQNVSQMHFARRGVLTEEMVYVARRENLDPELVRAEVARGRLIIPANINHPNLEPMGIGIAARCKVNANIGASPNASCLHEEVAKLDLAVKYGADTVMDLSTGGGDLDAIRSAIIQASPVPIGTVPMYQALESVHGSVEKLSAEDILTVIEKHAQQGVDYMTIHAGILIEHLPLVKGRITGIVSRGGGILARWMLAHHKQNPLYTHFDDICEIFKKYDVSFSLGDSLRPGCQHDASDAAQFAELKTLGELTRRAWEHDVQVMVEGPGHVPMHQIEMNVRRQMQECSEAPFYVLGPLVTDIAPGYDHITSAIGAAMAGWYGTAMLCYVTPKEHLGLPGPEDVRTGLIAYKIAAHAADIARGRPGARERDDELSRARYNFDWNRQFALALDPERAREYHDETLPADIYKSAEFCSMCGPKFCPMQTKIDSEVLDELERTLKPQPVTAQE
>NC_022600.1|WP_023172576.1|1262514_1263060_-|cysteine-hydrolase
MLKINTALVLIDVQVGFDDPVWGERNNPDAEQHIGELLTHWRRAGRPVIHVQHLSTLADSPLRPDRSGNAFKPEALPLPDEALFQKSVNSAFIGTDLQGYLKRQRVTGIVLVGLTTDHCVSTTARMGANLGFAVTVVEDAVATFERSFRGKHYPAGLIHETALASLAVEFAEVVAAAELLL
>NC_022600.1|WP_023172575.1|1261785_1262424_+|Uma2-family-endonuclease
MKTPAFLESTWVQADWDRFLVLANDPALQQAKCYYNCGWMRFEMSPVGPAHAAANSLIAQIISLYAYTHSIGLVSYINVSLRRPGLQEAQPDLAYYLSEQSPLPDWSNSPIDLRTTAVPALVVEVSATTLQDDLAAKRQLYGRLGVREYWVVDTAGKQVLLFAAVGDGGILQAQEESAVLPGLTSDLLAQALRLGTDEGDTAAIRFILEREG
>NC_022600.1|WP_023172574.1|1260226_1261717_+|type-II-and-III-secretion-system-protein
MKKLLYPASFVAALLLSAQARGAPPEQLRVRAVAPPAGDLAIEEIPPGRLLELGAGERITLLLKDAPVREVLQILARRAGCNIVFGSAAGAERISMDVQKESLEDTFNFALRLGHLQATRVGRTILVDAQIPADLLHNQIRTFRINQADAAQVAAMLGSLGAQINGSSFSASAEPPTSNPPASPAGTPTRQGPLTGELVVAVDARTNSLTAVGTPRALRLAQAQITRLDVRQRQVMIALKLVDVNLNNVSDLGFRIGGSGGNFQLGTVGGTGNLGNPYLSAGGITGTGGAGNTFIFNTLSALAQAMALRLDAAIQEGSARVLASPQIVVQAGESFRQPAAARVEITDDVVVGATTSSDRTTGLSNTTVKLDKVGVILDISVFHIDDNGYIDVALKPQVSSVIDAQRDAANNLVTLLTRRNLDIQRVRLRDGETFVIGGVLREIDRQIVQKVPILGDLPLLGPLFRFQNTQNERREVALTVTPHILNEGSADVQEKP
>NC_022600.1|WP_023172573.1|1259660_1260230_+|hypothetical-protein
MLPTPLISRGEPLRPGNYSLWIALFAVLAVAVAGFVYSLQPSPEEPAAPGVQGEPEPPPAEHPAHRLVPHSQTRSGLIPLLPLPTRPLPGGVTDPFLSPTPKPPQLSTAPPIPIYRPVPRPVRPGAPRIVGIIGGGDLCAIVLWGERFLTVHPGDRVGDLRVRSISPARSSVTFDRGGRLLIGVLETRP
>NC_022600.1|WP_023172572.1|1258974_1259640_+|type-4a-pilus-biogenesis-protein-PilO
MSSTTRLFGIELDRRGISLLVGLGGMLVVGLIAAQITIPQYNRIADLDSQLYQKNLEQKSKQIELEQAPKLTAERARSARLLAAVTSLIPPADKLPSLLVDTTRLVRANRAELRQFTPNPTRAIPEAAGAANIQANSARIRLNGSFAEILALMRDIERLEALVRIENVTIKAAEDKSGTPAQVQVPLPGTPPVQPLTAEFDLTAYVLGKGAAPPPPAKSDR
>NC_022600.1|WP_023172570.1|1257211_1258978_+|type-IV-pilus-assembly-protein-PilM
MTSVLASLFGNREGLGIEVTPEQTTIAQLENSGGRLRLRHLLSAATPAGAIVDGRVEDPRAVAATIQDLMATARLKARPVATAIPAREAVIRLFNLPADLQGAELRAVVLNQEAELYLPYPREEAYVDFQPLEAFVDPGGVRRQEILLVAAQYSVVNSYTEAIRRAGLEVAAVDIASFALTRALQGELQRFSPEEAVALVVLQADSTEINILFRGICQFSRTVSLGTWELRQLLERSKLLKPAGAAERQYAQEEALRRVLLDLAEEIRRSLDFYQAQGEGVPRVAQVLLAGSGADIPRLDQFLSQRLLLPVSRVDPLSALALPAQSVGEPYRAGVGAALGLGARSLKFPEKQPSAIFVPEINFLKDTAVAAASNGYVPALNTATEGIASIDPLLIAAAVPLVSLAVVAALSLIINAQVSSKEATLAELDGKITLLDRQLADVRQLKSDIEAERRRVEAVVDLFDLSRPWSAVLEDLRRRVPKGLWIESLESSHTKTGDTINIQGEALRFEEVAAFQLTLKDSPFIADAQLEDADKKDAKDARPATVAYKMQVRLNARKLRELMTALEQTGSAGLLEKLRRVQQEKLVR
>NC_022600.1|WP_023172568.1|1256362_1257190_+|A24-family-peptidase
MRGPFFLLAIGYWAILGAAAGSFANVVADRLPAGRSLLWPPSHCAQCGRVLRPLENVPVLGWLWLRGRCRSCGAAIPVRYAIVEALGALLFGLLAWHLGARFTPVSMVQTAFWGSFLTLLLALSLIDLDRLELPGELTSAGIVLGLGFRTFFPIWATGSWPAGPPGLVDALYGLILGIGLFDIVSYLGEKMLGKEAMGGGDAVLAAMIGVWLGWKLLLVALFVGFCLGAVGGILGLATGHLKRDEPLPFGPFLALGGVGGLLFGQSWLTGYLSLF
>NC_022600.1|WP_023172581.1|1268183_1269107_-|ABC-transporter-ATP-binding-protein
MLLEVCNLYRRYGEREAVAGLSFGVESGEIFGLLGPNGAGKSSTLGMIAGLIRPDAGSIRVAGIAGERARERIGFVPQALALYPALTACENLTFWGEIYGLKRHQLQERIRAVLDLVGLSERSQEPVARFSGGMQRRLNLAIGLIHQPQLLLLDEPTVGVDPQSRNRIFEGIEQLNREGLSILYTSHQLGEVEQLCHRVAVLDRGRIIAQGSPAELVARSGQGLVVLGVSAPLEEQLARLVVLPDVLNVQQAPGQVTIATARPQQVLAPVLEVLNKAGLAVQSVQLVEPSLEAVFLQLTGRSLRDEP
>NC_022600.1|WP_023172582.1|1269243_1269837_+|M23-family-metallopeptidase
MLRRWLLCAVLAASTAAGALASENSDRAQLALWRQVSFPLDNFTRISSHFGWRGSPTGGRRGEFHSGLDMPAPTGSYIRAWADGQVSDLSYDSRCGWHIVVVSGDWKSVFCHLSGVAVQQGQNVQAGQIVAAVGSTGRSTGPHLHWTLRYQGKLVNPELVIQAMALAWQGGAVPTVAPAADVPVEAQQDAVPGEQEP
>NC_022600.1|WP_144080332.1|1269919_1271440_+|SagB-family-peptide-dehydrogenase
MVYSQRSGSIPFCIFYHQKTKYSPEGLARRNHSIDWSHPPATSKGYRSGTVYDLKPYLSDTEKVQSNGLLDRLSRLLYLTYGVTAVVPYPDGPFYMRAAPSAGGLYPAEVYLLSRGLPELPAGAYNYLVPAHTLVHFWSGEGWQGLSDACFDHPALKQAQIAIVISAVFQRSAWRYEDRAYRRIFLDSGHLLGNLELAAALEAYRVRLITGFADDALNGLLFLPPSEEEALAVAALVEADAPDHPPGRQALPSPVHGNYPPVPEGQLLDYLHRVSKIDARPPTSPPAVVQADKYNFPFCLKVSTQSGPLDWDAKLEETILRRRSTRRYTGEDLNFAELAWLLDFTYQPQHYAAQGFDPAPEFAHLELLSTFVAVLGVQGLEAGCYYYAPQAQELRQIRFKNFRPEIHHLCLGQDLGRDSAAVVFHTADLAAATALYGERAYRTLHLDSGHLGQRLNLAAIRLGLGVSGIGGFFDDQVNEVLGIPEQEAVLYITTLGRPARSATADG
>NC_022600.1|WP_023172584.1|1271432_1272119_+|hypothetical-protein
MGDLRLAAVCLAMLLGAAGAAWADETVQPPAAKPMSREDLQRGSPTLRRWISDPPDLLNDIENGQAFPTRLGIGLVFTPSRSGEAAYTVSLQDVVLGGTRLSFSGDFTRSGTSNQAWGAEARYYVAPLGSYLNVAPQVGYRNIVIDGTTRNGLEAGAKFLFALAPRAADIAVSQSWVLPDRGGSIGRTVLEVGYTLSPVLRLTAVVQWINSSLRSDTSFGVNFELIGF
>NC_022600.1|WP_023172585.1|1272115_1273777_-|hypothetical-protein
MLIKSYLPVATVAIGTLSAVVFQASSVQPFTTLHHGHLYPAVPVTANRSGVFWRPLPAYAAVGKIGKLVAAADKQSAPPPQLVRTIASGSRTSFQFALTNADRSARLSVRGLPAEARYRFVINSNQATLYVWTTPWTPGGQSTLIIGGSTAAGAIKPVSATLITQSVPVSAAYGIWTPTVWDTCSVDIHNSYSVVGPDGKLYPTWHPPVDPATGCTFGHEHGMDPSGFSAYDLTGGVPFGLANEALDAYAPTTGSTDMRHEDHVGHKISYVENVASSTVRGNTCSILTHVHQGTHSADAFSNNLHEVSYYARCSDGTQFAVDVLASFGVGGQFLKGCDHATPVTTVPPVPADSPSGPIQSQRDIPELSCVQKFILVPNGQTSQFSTNDANHTFGGLYESWAATIKITALNQKSALVFLTPSFPVINPSRYYNPSFTNGLGRSIDICSMVESNGDAVHGTTPCSLVAPGTTYDNPASPFNGAHRVVAQFGQLKVNNPTGPTVWYTDPYGGNGQTTPFTGSIEQFISANANATGQSFGIDDMDVNFSATGVHSPN
>NC_022600.1|WP_023172586.1|1273901_1274702_-|glutamate-racemase
MVLGVFDSGVGGLTVLQQIIRQMPGTAVLYFADTARLPYGGRTTGEICRYVREILHWFESEGVDRVLMACNTSSALALPVVRHEFDISIDGLIDAGAEAALAAGGERIGVIATAATVASRAYSRAIRERSRRAQVWEVACPAFVPLIEGGQWMSDQMRIVARQYLEPLLKQRIDALIYGCTHYPYLAPIFEEFIPASIQRIDPAVAAVARLKATGQPPQECTDQAHYRFCVSGDPEQFAHAASAWLGYRPAVCAVNLPTLPVGLRG
>NC_022600.1|WP_023172587.1|1274870_1275752_+|polysaccharide-deacetylase-family-protein
MRNLPRSFVLALLSLFMLGAALYLSRFTPPAPASPATPPAVLLPPIPAVASLPEPPPAASVTNPPVPASFQGKIFKQGHLKRGEKVVALTFDDGPWPDSTRQVLAILRRNQITATFFCIGRHIQEHPELLKEVAVAGQVLGNHTWNHLYRPLSTARAAGEIDRTEALIKKITGVETRLFRPPGGVLGNGQVAYARRRDYAVVLWSVDSGDSHRHPTAAGMIRRVLAGVRPGGVVLLHDGGGLHPTVHALPQIIAGLKAKGYRFVTVPELMAMQVQQQAPPAIKVPLPATSAGQ
>NC_022600.1|WP_187293896.1|1275757_1276165_-|hypothetical-protein
MARELKVVDREFFRRLTVEALRTAIRSRLSDRVEEASRRGEDLQDPATWLDLVLIDAVVRLENIDGSSFRVAVLVTTRDRHALNELGLVKSQNFRAVRSALGIDRHWVLLLDSVAPPAQEQLVDALYEQIDQSGE
>NC_022600.1|WP_023172589.1|1276311_1276755_-|DUF4079-domain-containing-protein
MPWTTWLHPLLMLLVVFPAGFAAAALGLQLQQVRTERGARRKVSPKQARERHIAVGVVFLVAVAVVATIGGFVGVHLAKPVDTSWHGIGALSVVILLIISTALVTLKPLKRLRQARFIHSILNGTVIALLVLQFLSGGWIVRQLLRG
>NC_022600.1|WP_023172590.1|1276803_1278156_-|Ig-like-domain-containing-protein
MRGRWQRALGATILAGGLIGLTAPEARAQPLVPMLVAQAVPQIDTFSAEPVNDLSPGTELIFTVEGSPGSKATISIAGVTTKLPMREIESGTYEARYTIKRRDKITGTTAIRATLRKGKRTATARLSAPLLDTAQSGSPSGSGGGNTTVSIDRFAIDPPVDRLEPGTELVFKLNGTPQARASFTIAGVVTNQAMSEVSPGAYEGRYTIRRNDNFPPGVAITATLESQGQTARYRLQQGLINDDQPPTVQNPSPANNGVASSLRPLISAVFDDGRGSGVDPKSVRIRFDGQDVTSDATITANFFNYQPPRNLAQGTYRVEVDLKDLSGNPGGSSWQFQINRQAAVPQPQQLLLQVTSPANNSQVPAGAVTVRGKSSPGATIAVNVQATTSLVGLFGVNQQVLDQTIQADAQGNFSFQFRSPISAAGTRYEINLTANKNGQSRQQKLILIQQ

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Crispr_ID: NC_022600_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022600_2

2066878-2070197

TypeI-D

Consensus_repeat	Method
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	PILER-CR
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CRISPRCasFinder
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CRT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	PILER-CR
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	PILER-CR

45 spacers

cas2,cas1,cas4,cas6,csc1gr5,csc2gr7,cas10d,cas3,WYL

The CRISPR arrays of NC_022600_2

>merge|NC_022600|2|2066878-2070197|PILER-CR,CRISPRCasFinder,CRT,PILER-CR,PILER-CR
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTTATCCCCCTGGGCGGACAGTAAGGCCGTCTGGGAATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACAGTGACTTCAGTAAAATAACGGTAGGGAGTATCGTTAATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCATTGATCGGAGGTAATCGCTTCCCGGTATACCAGCATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACAGGATGCTCCCAGACGTTAGCGCCTATTTCCAATCTATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACACGTAGCCAAATCTTAATCCTTCAAAATCAACGAATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACACCAGCCCGGATCGACAGCATATCGCCTACCAGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACGAGAACTGATTCGGCTGCTTTGAGACGAGTTTTCATATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACGACAGGAATACTGCGGTGTATCGGCTGCGGGAGCATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTTGTCTTTTAATGTGACCGGATCGCGGGAATAAAAATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCCCGTAAAAAAATCAACTTGCGTATCGTCGTACAGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTCGTAGGCCAAGCCCTGGCCCATGCTGCGGCTGCGGCGCTATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCCGGTAAACAAACCACCCCGCCCGCCAACCGCACATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCGCAGCGTCAGCGCGGACAATAGATTGTCTTTTCTCATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACAACCAACGGTTACGGGCAGCAGCGCTAAGGCCAGGGTATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACGTAGTAGCTGCGGATCAACCGCCCTTGATAGGGAAGAAATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCGTTGGCCCCAGCACGCCTGGTTTCTTGGCAGACGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACGTAAAGCTTGAGCACGCCAGCTACGGCAGACAGGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCAGCGGCAGCTTTGCCGGTGGCGGTTTCTTTAATAGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACGCGCAGCGGGCCGTAGATAAACTGCTCTTCGAGGCATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCAGGTTCACGCTAAAGCACCGATCGCGGCGGTCGCCGCCGTGGCAAATCGGGCACATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACGGGGGCATCGAACATTTCGTGCAGCGCCCAGAGCGCGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACACGATCAACCCCGCCGAAGAATGGCTACCTGTACCATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTGCAGGTCGGCGGTAATTGGCATCAGCGCAACCAGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTTGGCACAACACACCAGGAGTAACAAGAATGCGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACGAGCGGGTGAGACGCTGGACGCGGTGGCGGGCTTCCATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACGCGCTGCCATCGCTGCCGAGCGCAAAGCTCGCAAATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCAGCTTGCTCGACCTGGGCAATGCGCTGGTCGAGGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCAGATGTGGGCACGGTGCGCCTCCTGGGGTAATTATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCACTGCGCCCGCTTCCACCCCAGCTGCTGCAGCAGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACAGGCTGAAAAGAATCGAGGATGGGATGCGGGTGCCATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACATGAGCACTGCGCCGACGTTGTTGCTGGAAGGAACAAGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACACTGCTTATCGCCTGCGGAGCGCGTCTCTTGGGCATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACAGAAGCTGGTTTGCCGATTGGGATATTTCGGGAACATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTAAAAGTTTGATCGCGCTTCCGGTGGAGTAGCGCCATATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTGAAGTTATCACAAAATCTGGGTTTAACACCGCTGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTGGGTAGTAGCGGTTTGGCGGGTGGCGAAATTGTAATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTCGGAAGCGATTATCTTCGAGACTTTAGCGGAAGCTTCCGAAGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTTGATGAGATGCCAGCCTACCGCCGTAAATCGAATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCGTGCCCAACGGCACCGGGGATATGGACTGGATAGAATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTAGGAGGCGTCGCGCTTTCCTATTTGCACAATATCAAATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACATTTTCGACGCAATTGATCATTCGTTTTCCAATAGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACGCCCTACCCTTTCACAATTGGCGACACTTTCGACATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCTAAGCACTGCCCGTGCAGGCCGGGGGCAGGATCATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACAGGTAGAGAACTCAAGATCTCCTCGAAGGCGAACGATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACAGACGCACATCCTCAGCAGAAGGATCAGTGATGCCGCATCGAAACGACCACCATCCCTGCAAAGGGATTGGCTA

>NC_022600|2|1|2066878-2067635|PILER-CR
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTATCCCCCTGGGCGGACAGTAAGGCCGTCTGGGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGTGACTTCAGTAAAATAACGGTAGGGAGTATCGTTA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CATTGATCGGAGGTAATCGCTTCCCGGTATACCAGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGATGCTCCCAGACGTTAGCGCCTATTTCCAATCT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACGTAGCCAAATCTTAATCCTTCAAAATCAACGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACCAGCCCGGATCGACAGCATATCGCCTACCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GAGAACTGATTCGGCTGCTTTGAGACGAGTTTTCAT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GACAGGAATACTGCGGTGTATCGGCTGCGGGAGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGTCTTTTAATGTGACCGGATCGCGGGAATAAAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CCCGTAAAAAAATCAACTTGCGTATCGTCGTACAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTCGTAGGCCAAGCCCTGGCCCATGCTGCGGCTGCGGCGCTATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCCGGTAAACAAACCACCCCGCCCGCCAACCGCACATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGCAGCGTCAGCGCGGACAATAGATTGTCTTTTCTC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AACCAACGGTTACGGGCAGCAGCGCTAAGGCCAGGGT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GTAGTAGCTGCGGATCAACCGCCCTTGATAGGGAAGAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGTTGGCCCCAGCACGCCTGGTTTCTTGGCAGACG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GTAAAGCTTGAGCACGCCAGCTACGGCAGACAGG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGCGGCAGCTTTGCCGGTGGCGGTTTCTTTAATAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCGCAGCGGGCCGTAGATAAACTGCTCTTCGAGGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCAGGTTCACGCTAAAGCACCGATCGCGGCGGTCGCCGCCGTGGCAAATCGGGCACATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GGGGGCATCGAACATTTCGTGCAGCGCCCAGAGCGCG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACGATCAACCCCGCCGAAGAATGGCTACCTGTACC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGCAGGTCGGCGGTAATTGGCATCAGCGCAACCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGGCACAACACACCAGGAGTAACAAGAATGCG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GAGCGGGTGAGACGCTGGACGCGGTGGCGGGCTTCC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCGCTGCCATCGCTGCCGAGCGCAAAGCTCGCAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGCTTGCTCGACCTGGGCAATGCGCTGGTCGAGG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGATGTGGGCACGGTGCGCCTCCTGGGGTAATT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CACTGCGCCCGCTTCCACCCCAGCTGCTGCAGCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGCTGAAAAGAATCGAGGATGGGATGCGGGTGCC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ATGAGCACTGCGCCGACGTTGTTGCTGGAAGGAACAAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACTGCTTATCGCCTGCGGAGCGCGTCTCTTGGGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGAAGCTGGTTTGCCGATTGGGATATTTCGGGAAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TAAAAGTTTGATCGCGCTTCCGGTGGAGTAGCGCCAT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGAAGTTATCACAAAATCTGGGTTTAACACCGCTG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGGGTAGTAGCGGTTTGGCGGGTGGCGAAATTGTA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TCGGAAGCGATTATCTTCGAGACTTTAGCGGAAGCTTCCGAAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGATGAGATGCCAGCCTACCGCCGTAAATCGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGTGCCCAACGGCACCGGGGATATGGACTGGATAGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TAGGAGGCGTCGCGCTTTCCTATTTGCACAATATCAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ATTTTCGACGCAATTGATCATTCGTTTTCCAATAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCCCTACCCTTTCACAATTGGCGACACTTTCGAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CTAAGCACTGCCCGTGCAGGCCGGGGGCAGGATC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGTAGAGAACTCAAGATCTCCTCGAAGGCGAACG


>NC_022600|2|2|2066878-2070197|CRISPRCasFinder
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTATCCCCCTGGGCGGACAGTAAGGCCGTCTGGGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGTGACTTCAGTAAAATAACGGTAGGGAGTATCGTTA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CATTGATCGGAGGTAATCGCTTCCCGGTATACCAGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGATGCTCCCAGACGTTAGCGCCTATTTCCAATCT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACGTAGCCAAATCTTAATCCTTCAAAATCAACGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACCAGCCCGGATCGACAGCATATCGCCTACCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GAGAACTGATTCGGCTGCTTTGAGACGAGTTTTCAT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GACAGGAATACTGCGGTGTATCGGCTGCGGGAGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGTCTTTTAATGTGACCGGATCGCGGGAATAAAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CCCGTAAAAAAATCAACTTGCGTATCGTCGTACAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TCGTAGGCCAAGCCCTGGCCCATGCTGCGGCTGCGGCGCT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CCGGTAAACAAACCACCCCGCCCGCCAACCGCAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGCAGCGTCAGCGCGGACAATAGATTGTCTTTTCTC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AACCAACGGTTACGGGCAGCAGCGCTAAGGCCAGGGT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GTAGTAGCTGCGGATCAACCGCCCTTGATAGGGAAGAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGTTGGCCCCAGCACGCCTGGTTTCTTGGCAGACG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GTAAAGCTTGAGCACGCCAGCTACGGCAGACAGG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGCGGCAGCTTTGCCGGTGGCGGTTTCTTTAATAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCGCAGCGGGCCGTAGATAAACTGCTCTTCGAGGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGGTTCACGCTAAAGCACCGATCGCGGCGGTCGCCGCCGTGGCAAATCGGGCAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GGGGGCATCGAACATTTCGTGCAGCGCCCAGAGCGCG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACGATCAACCCCGCCGAAGAATGGCTACCTGTACC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGCAGGTCGGCGGTAATTGGCATCAGCGCAACCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGGCACAACACACCAGGAGTAACAAGAATGCG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GAGCGGGTGAGACGCTGGACGCGGTGGCGGGCTTCC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCGCTGCCATCGCTGCCGAGCGCAAAGCTCGCAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGCTTGCTCGACCTGGGCAATGCGCTGGTCGAGG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGATGTGGGCACGGTGCGCCTCCTGGGGTAATT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CACTGCGCCCGCTTCCACCCCAGCTGCTGCAGCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGCTGAAAAGAATCGAGGATGGGATGCGGGTGCC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ATGAGCACTGCGCCGACGTTGTTGCTGGAAGGAACAAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACTGCTTATCGCCTGCGGAGCGCGTCTCTTGGGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGAAGCTGGTTTGCCGATTGGGATATTTCGGGAAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TAAAAGTTTGATCGCGCTTCCGGTGGAGTAGCGCCAT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGAAGTTATCACAAAATCTGGGTTTAACACCGCTG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGGGTAGTAGCGGTTTGGCGGGTGGCGAAATTGTA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TCGGAAGCGATTATCTTCGAGACTTTAGCGGAAGCTTCCGAAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGATGAGATGCCAGCCTACCGCCGTAAATCGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGTGCCCAACGGCACCGGGGATATGGACTGGATAGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TAGGAGGCGTCGCGCTTTCCTATTTGCACAATATCAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ATTTTCGACGCAATTGATCATTCGTTTTCCAATAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCCCTACCCTTTCACAATTGGCGACACTTTCGAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CTAAGCACTGCCCGTGCAGGCCGGGGGCAGGATC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGTAGAGAACTCAAGATCTCCTCGAAGGCGAACG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGACGCACATCCTCAGCAGAAGGATCAGTGATGCCGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGGCTA

>NC_022600|2|1|2066878-2070197|CRT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTATCCCCCTGGGCGGACAGTAAGGCCGTCTGGGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGTGACTTCAGTAAAATAACGGTAGGGAGTATCGTTA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CATTGATCGGAGGTAATCGCTTCCCGGTATACCAGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGATGCTCCCAGACGTTAGCGCCTATTTCCAATCT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACGTAGCCAAATCTTAATCCTTCAAAATCAACGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACCAGCCCGGATCGACAGCATATCGCCTACCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GAGAACTGATTCGGCTGCTTTGAGACGAGTTTTCAT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GACAGGAATACTGCGGTGTATCGGCTGCGGGAGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGTCTTTTAATGTGACCGGATCGCGGGAATAAAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CCCGTAAAAAAATCAACTTGCGTATCGTCGTACAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TCGTAGGCCAAGCCCTGGCCCATGCTGCGGCTGCGGCGCT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CCGGTAAACAAACCACCCCGCCCGCCAACCGCAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGCAGCGTCAGCGCGGACAATAGATTGTCTTTTCTC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AACCAACGGTTACGGGCAGCAGCGCTAAGGCCAGGGT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GTAGTAGCTGCGGATCAACCGCCCTTGATAGGGAAGAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGTTGGCCCCAGCACGCCTGGTTTCTTGGCAGACG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GTAAAGCTTGAGCACGCCAGCTACGGCAGACAGG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGCGGCAGCTTTGCCGGTGGCGGTTTCTTTAATAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCGCAGCGGGCCGTAGATAAACTGCTCTTCGAGGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGGTTCACGCTAAAGCACCGATCGCGGCGGTCGCCGCCGTGGCAAATCGGGCAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GGGGGCATCGAACATTTCGTGCAGCGCCCAGAGCGCG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACGATCAACCCCGCCGAAGAATGGCTACCTGTACC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGCAGGTCGGCGGTAATTGGCATCAGCGCAACCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGGCACAACACACCAGGAGTAACAAGAATGCG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GAGCGGGTGAGACGCTGGACGCGGTGGCGGGCTTCC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCGCTGCCATCGCTGCCGAGCGCAAAGCTCGCAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGCTTGCTCGACCTGGGCAATGCGCTGGTCGAGG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGATGTGGGCACGGTGCGCCTCCTGGGGTAATT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CACTGCGCCCGCTTCCACCCCAGCTGCTGCAGCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGCTGAAAAGAATCGAGGATGGGATGCGGGTGCC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ATGAGCACTGCGCCGACGTTGTTGCTGGAAGGAACAAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACTGCTTATCGCCTGCGGAGCGCGTCTCTTGGGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGAAGCTGGTTTGCCGATTGGGATATTTCGGGAAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TAAAAGTTTGATCGCGCTTCCGGTGGAGTAGCGCCAT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGAAGTTATCACAAAATCTGGGTTTAACACCGCTG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGGGTAGTAGCGGTTTGGCGGGTGGCGAAATTGTA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TCGGAAGCGATTATCTTCGAGACTTTAGCGGAAGCTTCCGAAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGATGAGATGCCAGCCTACCGCCGTAAATCGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGTGCCCAACGGCACCGGGGATATGGACTGGATAGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TAGGAGGCGTCGCGCTTTCCTATTTGCACAATATCAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ATTTTCGACGCAATTGATCATTCGTTTTCCAATAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCCCTACCCTTTCACAATTGGCGACACTTTCGAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CTAAGCACTGCCCGTGCAGGCCGGGGGCAGGATC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGTAGAGAACTCAAGATCTCCTCGAAGGCGAACG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGACGCACATCCTCAGCAGAAGGATCAGTGATGCCGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGGCTA

>NC_022600|2|2|2067747-2068293|PILER-CR
	TTATCCCCCTGGGCGGACAGTAAGGCCGTCTGGGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGTGACTTCAGTAAAATAACGGTAGGGAGTATCGTTA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CATTGATCGGAGGTAATCGCTTCCCGGTATACCAGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGATGCTCCCAGACGTTAGCGCCTATTTCCAATCT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACGTAGCCAAATCTTAATCCTTCAAAATCAACGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACCAGCCCGGATCGACAGCATATCGCCTACCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GAGAACTGATTCGGCTGCTTTGAGACGAGTTTTCAT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GACAGGAATACTGCGGTGTATCGGCTGCGGGAGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGTCTTTTAATGTGACCGGATCGCGGGAATAAAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CCCGTAAAAAAATCAACTTGCGTATCGTCGTACAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTCGTAGGCCAAGCCCTGGCCCATGCTGCGGCTGCGGCGCTATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCCGGTAAACAAACCACCCCGCCCGCCAACCGCACATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGCAGCGTCAGCGCGGACAATAGATTGTCTTTTCTC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AACCAACGGTTACGGGCAGCAGCGCTAAGGCCAGGGT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GTAGTAGCTGCGGATCAACCGCCCTTGATAGGGAAGAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGTTGGCCCCAGCACGCCTGGTTTCTTGGCAGACG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GTAAAGCTTGAGCACGCCAGCTACGGCAGACAGG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGCGGCAGCTTTGCCGGTGGCGGTTTCTTTAATAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCGCAGCGGGCCGTAGATAAACTGCTCTTCGAGGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCAGGTTCACGCTAAAGCACCGATCGCGGCGGTCGCCGCCGTGGCAAATCGGGCACATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GGGGGCATCGAACATTTCGTGCAGCGCCCAGAGCGCG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACGATCAACCCCGCCGAAGAATGGCTACCTGTACC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGCAGGTCGGCGGTAATTGGCATCAGCGCAACCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGGCACAACACACCAGGAGTAACAAGAATGCG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GAGCGGGTGAGACGCTGGACGCGGTGGCGGGCTTCC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCGCTGCCATCGCTGCCGAGCGCAAAGCTCGCAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGCTTGCTCGACCTGGGCAATGCGCTGGTCGAGG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGATGTGGGCACGGTGCGCCTCCTGGGGTAATT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CACTGCGCCCGCTTCCACCCCAGCTGCTGCAGCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGCTGAAAAGAATCGAGGATGGGATGCGGGTGCC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ATGAGCACTGCGCCGACGTTGTTGCTGGAAGGAACAAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACTGCTTATCGCCTGCGGAGCGCGTCTCTTGGGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGAAGCTGGTTTGCCGATTGGGATATTTCGGGAAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TAAAAGTTTGATCGCGCTTCCGGTGGAGTAGCGCCAT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGAAGTTATCACAAAATCTGGGTTTAACACCGCTG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGGGTAGTAGCGGTTTGGCGGGTGGCGAAATTGTA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TCGGAAGCGATTATCTTCGAGACTTTAGCGGAAGCTTCCGAAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGATGAGATGCCAGCCTACCGCCGTAAATCGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGTGCCCAACGGCACCGGGGATATGGACTGGATAGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TAGGAGGCGTCGCGCTTTCCTATTTGCACAATATCAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ATTTTCGACGCAATTGATCATTCGTTTTCCAATAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCCCTACCCTTTCACAATTGGCGACACTTTCGAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CTAAGCACTGCCCGTGCAGGCCGGGGGCAGGATC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGTAGAGAACTCAAGATCTCCTCGAAGGCGAACG


>NC_022600|2|3|2068349-2070123|PILER-CR
	TTATCCCCCTGGGCGGACAGTAAGGCCGTCTGGGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGTGACTTCAGTAAAATAACGGTAGGGAGTATCGTTA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CATTGATCGGAGGTAATCGCTTCCCGGTATACCAGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGATGCTCCCAGACGTTAGCGCCTATTTCCAATCT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACGTAGCCAAATCTTAATCCTTCAAAATCAACGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACCAGCCCGGATCGACAGCATATCGCCTACCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GAGAACTGATTCGGCTGCTTTGAGACGAGTTTTCAT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GACAGGAATACTGCGGTGTATCGGCTGCGGGAGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGTCTTTTAATGTGACCGGATCGCGGGAATAAAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CCCGTAAAAAAATCAACTTGCGTATCGTCGTACAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACTCGTAGGCCAAGCCCTGGCCCATGCTGCGGCTGCGGCGCTATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCCGGTAAACAAACCACCCCGCCCGCCAACCGCACATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGCAGCGTCAGCGCGGACAATAGATTGTCTTTTCTC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AACCAACGGTTACGGGCAGCAGCGCTAAGGCCAGGGT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GTAGTAGCTGCGGATCAACCGCCCTTGATAGGGAAGAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGTTGGCCCCAGCACGCCTGGTTTCTTGGCAGACG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GTAAAGCTTGAGCACGCCAGCTACGGCAGACAGG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGCGGCAGCTTTGCCGGTGGCGGTTTCTTTAATAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCGCAGCGGGCCGTAGATAAACTGCTCTTCGAGGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAACCAGGTTCACGCTAAAGCACCGATCGCGGCGGTCGCCGCCGTGGCAAATCGGGCACATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GGGGGCATCGAACATTTCGTGCAGCGCCCAGAGCGCG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACGATCAACCCCGCCGAAGAATGGCTACCTGTACC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGCAGGTCGGCGGTAATTGGCATCAGCGCAACCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGGCACAACACACCAGGAGTAACAAGAATGCG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GAGCGGGTGAGACGCTGGACGCGGTGGCGGGCTTCC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCGCTGCCATCGCTGCCGAGCGCAAAGCTCGCAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGCTTGCTCGACCTGGGCAATGCGCTGGTCGAGG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CAGATGTGGGCACGGTGCGCCTCCTGGGGTAATT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CACTGCGCCCGCTTCCACCCCAGCTGCTGCAGCAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGCTGAAAAGAATCGAGGATGGGATGCGGGTGCC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ATGAGCACTGCGCCGACGTTGTTGCTGGAAGGAACAAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ACTGCTTATCGCCTGCGGAGCGCGTCTCTTGGGC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGAAGCTGGTTTGCCGATTGGGATATTTCGGGAAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TAAAAGTTTGATCGCGCTTCCGGTGGAGTAGCGCCAT
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGAAGTTATCACAAAATCTGGGTTTAACACCGCTG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TGGGTAGTAGCGGTTTGGCGGGTGGCGAAATTGTA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TCGGAAGCGATTATCTTCGAGACTTTAGCGGAAGCTTCCGAAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TTGATGAGATGCCAGCCTACCGCCGTAAATCGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CGTGCCCAACGGCACCGGGGATATGGACTGGATAGA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	TAGGAGGCGTCGCGCTTTCCTATTTGCACAATATCAA
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	ATTTTCGACGCAATTGATCATTCGTTTTCCAATAG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	GCCCTACCCTTTCACAATTGGCGACACTTTCGAC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	CTAAGCACTGCCCGTGCAGGCCGGGGGCAGGATC
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC	AGGTAGAGAACTCAAGATCTCCTCGAAGGCGAACG
ATCGAAACGACCACCATCCCTGCAAAGGGATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022600.1\|WP_023173346.1\|2081236_2081836_+\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023173335.1\|2065336_2066341_+\|type-I-D-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|376633
NC_022600.1\|WP_023173341.1\|2074196_2075498_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NC_022600.1\|WP_023173328.1\|2055497_2056352_-\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_022600.1\|WP_023173348.1\|2082526_2084701_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NC_022600.1\|WP_023173332.1\|2063173_2063884_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	csc1gr5	cd09711_csc1gr5_CAS-I-D	gnl\|CDD\|187842
NC_022600.1\|WP_023173327.1\|2054822_2055488_+\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|224331
NC_022600.1\|WP_023173336.1\|2066344_2066620_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_022600.1\|WP_023173345.1\|2079989_2081156_+\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|225412
NC_022600.1\|WP_041243855.1\|2076744_2078049_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|225118
NC_022600.1\|WP_023173330.1\|2058857_2062139_+\|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	cas10d	cd09712_cas10d_CAS-I-D	gnl\|CDD\|274469
NC_022600.1\|WP_023173342.1\|2075531_2076623_-\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	unknown	unknown	gnl\|CDD\|340818
NC_022600.1\|WP_041244601.1\|2082004_2082520_+\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|376760
NC_022600.1\|WP_023173333.1\|2063915_2064740_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG5551_cas6_CAS-III	gnl\|CDD\|227838
NC_022600.1\|WP_041244599.1\|2064739_2065333_+\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|187768
NC_022600.1\|WP_023173344.1\|2078116_2079700_+\|Na+/solute-symporter	unknown	unknown	gnl\|CDD\|271371
NC_022600.1\|WP_023173329.1\|2056445_2058626_+\|type-I-D-CRISPR-associated-helicase-Cas3'	cas3	cd09710_cas3_CAS-I-D	gnl\|CDD\|187841
NC_022600.1\|WP_023173339.1\|2071694_2072603_-\|prohibitin-family-protein	unknown	unknown	gnl\|CDD\|259799
NC_022600.1\|WP_023173331.1\|2062164_2063172_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	csc2gr7	cd09709_csc2gr7_CAS-I-D	gnl\|CDD\|375747
NC_022600.1\|WP_023173340.1\|2072991_2074131_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|226614

Protein	Function_ID	Function_description	E-value
NC_022600.1\|WP_023173335.1\|2065336_2066341_+\|type-I-D-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	1.801e-132
NC_022600.1\|WP_023173341.1\|2074196_2075498_+\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	3.22505e-99
NC_022600.1\|WP_023173328.1\|2055497_2056352_-\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	1.874e-06
NC_022600.1\|WP_023173348.1\|2082526_2084701_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	8.99994e-121
NC_022600.1\|WP_023173332.1\|2063173_2063884_+\|type-I-D-CRISPR-associated-protein-Cas5/Csc1	gnl\|CDD\|187842	cd09711, Csc1_I-D, CRISPR/Cas system-associated protein Csc1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; predicted Cas5 ortholog; also known as CasA/Cse1 family.	1.39536e-64
NC_022600.1\|WP_023173327.1\|2054822_2055488_+\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	5.29647e-22
NC_022600.1\|WP_023173336.1\|2066344_2066620_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.89197e-37
NC_022600.1\|WP_023173345.1\|2079989_2081156_+\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|225412	COG2856, COG2856, Predicted Zn peptidase [Amino acid transport and metabolism].	3.58366e-15
NC_022600.1\|WP_041243855.1\|2076744_2078049_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|225118	COG2208, RsbU, Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription].	4.20112e-79
NC_022600.1\|WP_023173330.1\|2058857_2062139_+\|type-I-D-CRISPR-associated-protein-Cas10d/Csc3	gnl\|CDD\|274469	TIGR03174, cas_Csc3, CRISPR type I-D/CYANO-associated protein Csc3/Cas10d. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family is a CRISPR-associated (Cas) family strictly associated with the Cyano subtype of CRISPR/Cas locus, found in several species of Cyanobacteria and several archaeal species. This family is designated Csc3 for CRISPR/Cas Subtype Cyano protein 3, as it is often the third gene upstream of the core cas genes, cas3-cas4-cas1-cas2.	0
NC_022600.1\|WP_023173342.1\|2075531_2076623_-\|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase	gnl\|CDD\|340818	cd03785, GT28_MurG, undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	6.0358e-127
NC_022600.1\|WP_041244601.1\|2082004_2082520_+\|MgtC/SapB-family-protein	gnl\|CDD\|376760	pfam02308, MgtC, MgtC family. The MgtC protein is found in an operon with the Mg2+ transporter protein MgtB. The function of MgtC and its homologs is not known.	6.28079e-37
NC_022600.1\|WP_023173333.1\|2063915_2064740_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|227838	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.65869e-39
NC_022600.1\|WP_041244599.1\|2064739_2065333_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|187768	cd09637, Cas4_I-A_I-B_I-C_I-D_II-B, CRISPR/Cas system-associated protein Cas4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster.	1.32854e-43
NC_022600.1\|WP_023173344.1\|2078116_2079700_+\|Na+/solute-symporter	gnl\|CDD\|271371	cd11477, SLC5sbd_u1, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	1.28076e-120
NC_022600.1\|WP_023173329.1\|2056445_2058626_+\|type-I-D-CRISPR-associated-helicase-Cas3'	gnl\|CDD\|187841	cd09710, Cas3_I-D, CRISPR/Cas system-associated protein Cas3; Distinct diverged subfamily of Cas3 helicase domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Diverged DNA helicase Cas3'; signature gene for Type I and subtype I-D.	1.10838e-114
NC_022600.1\|WP_023173339.1\|2071694_2072603_-\|prohibitin-family-protein	gnl\|CDD\|259799	cd03401, SPFH_prohibitin, Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model characterizes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of the SPFH (band 7) domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. These microdomains, in addition to being stable scaffolds, may also be dynamic units with their own regulatory functions. Prohibitin is a mitochondrial inner-membrane protein which may act as a chaperone for the stabilization of mitochondrial proteins. Human prohibitin forms a hetero-oligomeric complex with Bap-37 (prohibitin 2, an SPFH domain carrying homolog). This complex may protect non-assembled membrane proteins against proteolysis by the m-AAA protease. Prohibitin and Bap-37 yeast homologs have been implicated in yeast longevity and in the maintenance of mitochondrial morphology.	2.67699e-44
NC_022600.1\|WP_023173331.1\|2062164_2063172_+\|type-I-D-CRISPR-associated-protein-Cas7/Csc2	gnl\|CDD\|375747	pfam18320, Csc2, Csc2 Crispr. The Csc2 Crispr family of proteins forms a core RNA recognition motif-like domain, flanked by three peripheral insertion domains: a lid domain, a Zinc-binding domain and a helical domain. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	1.70956e-180
NC_022600.1\|WP_023173340.1\|2072991_2074131_+\|FUSC-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	1.60614e-21

>NC_022600.1|WP_023173336.1|2066344_2066620_+|CRISPR-associated-endonuclease-Cas2
MFVLVSYDIPNDKRRTKIHNALKSYGEWVQFSVFECDLDDTNYARLRARLSALIKPEEDSIRFYFLCRTCSPKIERIGGKPPTDDSIFFAG
>NC_022600.1|WP_023173335.1|2065336_2066341_+|type-I-D-CRISPR-associated-endonuclease-Cas1
MGTVYVNQEDAFLGRSDERLKITHERRTLLEVPLLRIDGIVVLGRAHFSPALMGELLERRIPMSFLSPTGRYLGRVEPELSKNIFVRSAQWRASEQPERTLHLARAFVRGKLKNCRNDLMRAQREHPELNVQKAIESIQQNIDALPRTENVDSVRGLEGAGSASYFAVFEQLIRVKGFSFTHRNRRPPLDPVNALLSFGYSLLRHDIQSALNIVGFDPYLGFLHTQRYGRPSLALDLMEEFRPLVVDAMILGCLNKSVLQPTDFESEPLSGAVSLNAEARKQFLRQYEQKKQSRFRHLVLEKQCTYQEAFEIQARLLSKYLLGETHQYPPLILK
>NC_022600.1|WP_041244599.1|2064739_2065333_+|CRISPR-associated-protein-Cas4
MADEQYVPIAALNQYAYCPHRCWRMFCAGGFTDNAATIEGSDLHRRVHTVGSGNRDEVQQWRGIWLRSEQYGLIGKADLIEYRENLYCPVEYKRGAQSDWDNDALQLCGQALCLEEMTGSTVPVGFIYSTRLHRREAVPLVGPVRMQTVETIAAVREMLTSGAMPPAIYSKRCEGCSLLEQCRPKLAAKVAKYQEEN
>NC_022600.1|WP_023173333.1|2063915_2064740_+|CRISPR-associated-endoribonuclease-Cas6
MPYSLVVNLLPREPIQPGYLEGRHLHALFLSMVNAVAPDLATHLHSDTRDKAFALSPLQTRSPDEALQTFHTRPIPAGTSCWWRIGLLDEALFSQLTQLWLNLNPRHAWHLGAANLEIASILATAQSPQPWANSQTYSALFESASAEERYLSLRFCTPTCFRQNDYDTALPTAELVFGSLLKRWQKYSPIAIPWEVIELVRRQVFPCRFAVETRRVADQRSKFIGCIGTITYEILGQVSPDLIRQINALADFALYAGVGRKTTMGMGMARRIRS
>NC_022600.1|WP_023173332.1|2063173_2063884_+|type-I-D-CRISPR-associated-protein-Cas5/Csc1
MVFVHRYCFELHDSLYFATREIGRLYETEPILHNYALCYALGLVDSDRHGTRVPEAQGYRYFSAEQVPHYAVHLEALNRAGIYVTPARTLQHTTVLNTWKYGDNRYRVEMGKTQKNIPSFGRAKEVAPGSTFEFFLIASKPLDLPRWIRLGKWLSKAELTLVNVRPLEPARSETEFVCAAPLNPLDVMFSHSVLSYDTVNMPPVSLIRNVRLRGIALDCDGIKLPGRMQFRFSAPA
>NC_022600.1|WP_023173331.1|2062164_2063172_+|type-I-D-CRISPR-associated-protein-Cas7/Csc2
MALLSTLDPKYFHSAIPYKPMGKYVHFLTVRITESYPLFQTDGELNKARVRAGIQDDTPISRLAMFKRKQSTPERLVGRELLRRYEIPGAEKCEYNVEFSMNTPDCILYGFAIGDSGSEKSKVVVDTAYSITAFDGSHERFTLNAPYENGTMASKGEPGTKAGEVTSRINSQDHIKPQVFFPSIVTLKDPTEAGFLYVFNNLLRTRHYGAQTTRTGKLRNELIGVSFSDGEILSNLRWTQAIYDAMKANDTLTDPLNEDEVIQAAARTITELLAKECVVHTDLIAEAFAPVLAEVRQLTGSEAGIRRLLEQADREAKEYNKNHIKQKATKAAKES
>NC_022600.1|WP_023173330.1|2058857_2062139_+|type-I-D-CRISPR-associated-protein-Cas10d/Csc3
MNFGDENEELYDESEEEDEEESLEFDAPGSEPSAAEALALRLLQGAIRAQNPDDRCMADFAEYVLPNLLRVTVGATAKGGEFFDNLDVQGIKIRRDNAADQSLATHLLNGIFPANLIEQRLEQMDTTIRRCVSERERRIVLAAFVLHDFEKFPDVTDQARGLPLEGQRQIVAEKIVQLGLDRFLDPENPDTWRTYLDDLLAIAFNTQRRWGTNWNFGAGGLRPVLPSRTLRQLTELTCLADSLASIVKHPWDAGHTKFKELLHELCEGQLVLTYHAITENRGVLTNILNNVLIDIHPAPHYTPLLYLPTGVIYLATKDAPPIDAADLPERVIERIKKLCAGELRRRQTGFGRDGKGMKFAEYYTLFFEDAGLMGVALDAVLKMMDPSKNKKPVSAARSENLKRFQSQKVLPEGFDFDFGDDTRIDQLAEFCDLVSRKIWGERRNKIEEACKKDKKLPAPEPVDLVAEICREWQLEECLPALKHIGRINESLRENNLKGNTGGVPYEWYYLAAQYLKHHPGIENVRSVCEGVIAYAARRLQPILERYPLPDGWDDLRAWVANTVVLPAQQRERELPQGTFLDELNRYQAAKKPGRGRQLICSISHSAYTVSEQMESAVLFTPQVYTNKQMLGGSNAKRNISSIAATEMMLRQILMSNTGAVGKRFEDGKYRYLYLYPTYYFTPETNRFLQKAYRAMAETRFTFKLRNHFVRKNFTADFSKANYQSVDAFLLDPELERSKDRTFKLAYPDDQPLTFYFMALPPGRDPTDTESWIMPAWLGLTLPLILDVKAVVSESPIPPFLDGSEFEETVFLDGAPQAIRSLVRNDSFRLNHLLGRNPKEPRQPPALTALTAAYAIHLDVFARQGDPKWNRLPELAFDLDTSPLYVFSYLKKWVRDQGVEAPSIDRIRLYAYSFYPCFDPEVSYIPDSEEFIVPETSPLNRPKTLTELYRRFYRAEKRYNASSRSVLRPLDDAASVVMLADPALRSDELVVLVAGGVGKLMDRVRASTAEGRWVIRDREAERLAILEFARYFVEDVFVKTFDSDRARLDGRQLNLLRDACEFLYRLEEDRELAAKPQPPGPDEPASPDESAPAA
>NC_022600.1|WP_023173329.1|2056445_2058626_+|type-I-D-CRISPR-associated-helicase-Cas3'
MPDTLLLKPVFSRPASTLPARIQLPPGWQRLAWHQAETLRALDDPEVDVIVNTAMTGDGKSLAAYLGVLTRDRTTIGMYPTNELARDQEGQVRGYIQQFAPSWEPRLVRVSGPELEVYAREAEIKKGAALSSLSAQREVLLTNPDIFHYLHRGAYIYDKDSSDRLWQRIDNDFELFIFDEFHVFGPPQVAAVINTLLLLRYTMGRKKFMFLSATPDPQLIERLRLAGFNVREIDPKAADCYRSPADDTEAQALTEQGWRRVSRGLELEFIRLEPSPRASEAWLRENASRILEYFLTYPGSRGAIILNSIASVKRLLPHFQAIFIAAGLTVRENTGLTGAAGRRESLEADLVLGTSTIDVGVDFKINFLVFESSDAGNFIQRLGRLGRHDGHESANGFAPFQHFKAIALAPNFFVERLFDTPEAPFSGGGTFDRFFLNEQIRAHYRQINEFSGYYKTWGAIQSLKIAYELGHTTIKAQYAEAKVAFSDACQQVFGVALSPLFGRVKGWEREWHELSGQKGNPIFDVATSFRGAGDLQCGLYDPTETHQADRFKTYGLPGVLANLQVEAWTKAEFLAALEEAEQRSGRPIARGAFKYCLAFFRLIGYREERLNWKFVYSGDIDELLQKSTAQVVRGLEVWQPENPDIREINKRLRQEGLVCFVVERPVLEVRNRLRLPMHFQIYPLADERSLYDANAPCSIAFGQSALLLDTLSARLPSPATSWIAGG
>NC_022600.1|WP_023173328.1|2055497_2056352_-|WYL-domain-containing-protein
MKRKQQTITLSLGNTDKARLENLAVELGVLWGERPNITQLVKNIAQRQLLVAHNADWSEERIGALVKAADLLLDVGEADAAQALGHLLLERGEVTGPLRDRLAERFQGVQASWRGIIDRYIRQTQPFRLLYQDAAERAWQLTVRYARIRFREKRLYLEIWSEECEGNREIPGLTHNWSLRLDRLQGVEVLPAPGKWRVGPDKIEVEMHLYEGLAHAYVPRPEDAVYRWLEREPVRQVVRRVDSTFWFLREIYPYGPDCLIVGPESVRARAIERFQQTCRRYTTS
>NC_022600.1|WP_023173327.1|2054822_2055488_+|HEAT-repeat-domain-containing-protein
MAASIEELRQQLASDVASDRIAAALDLRFVRSAEAAALLRQAAQDAVPLVRVYAAVGLARQDLDQAFETLVILLKSDPDGSVRAEAAGSLGLLRDRQAFEPLVDAYENDGDWIVRYSAIVALGQLAEPRSFAVFSAALDSPIEMIRDGAIGALGELGDRRAVERLLPLVGHPEAEVRRRVAVALGKIGDPASQSALGFLAKDDDPKVAEAAQSAMQALERP
>NC_022600.1|WP_023173339.1|2071694_2072603_-|prohibitin-family-protein
MQFLKGEKLAIQPIVPIVAGVVIAVLLVLNTWTTVQPGYVGIVFDKITHDVRVGLLEPGWVFINPLTESIQQYPVTIQTYSMVQKSSEGQVAGDDSIKIQSNEGQQLNLDAVIQYQVNKSEAARLYEEWGGASIETIEDRVVRQYTRSEVPQIAARYGWEEITSSRRSEIIQKIAARLSEEFQKRHLVLVSFAIREVHLPAVLQQALNQKIEAQQQAEKQRYTLQQTEIQAEQAKVEAQGKAAAILIRAKAQADANSLLSRSLTPELLRSQQIEKWNGILPSVTGSGALPILDLEQRGEAKK
>NC_022600.1|WP_023173340.1|2072991_2074131_+|FUSC-family-protein
MRILKQQLSAATVKIAFKAGVAALLAYLGAQGLGLRSPLWATISAVIVMQANLGSSFGASWQRLVGTAVGVLVGIVLVSLGGHNILLLGAGTTLTVLLCAVLGVYESFRIATVTFVLVALLGGTEPWSFGLHRFLDVAFGLLVALGVTVGLWPPRARRDLRHTLAALLEADARLYQRLVENYLSASNDSGSVLEARGAIKASLATARTLVGDIGREPPAAEDPALTSLLVVVERLQEDLFTLDRGIADSTGDGLQNHLRTELENLAQITVTTFTTLAAALREPQAVAHPAQLSQAVQAVDERFGELRRARVPSQYSADELLRFTSFLFSVQQVALELDNLAAEITGLTSAGQPGGWPARLLRPYRSAGVPLRSGRTHEN
>NC_022600.1|WP_023173341.1|2074196_2075498_+|amidohydrolase-family-protein
MRAVLLRLLVVVHFFILSFQAAQAETGSYLIKPAAVFDGVSEVLHPGWVVLVEGNRIAAAGPEQSVRPPASTRTIVLAGTTLLPGLIDLHSHLFLHPYNEALWVDQVLKEPPALRVARATVHARATLMAGFTTLRDLGTEGAGYADVGLKQAIEQGIIPGPQLVVVTRAIVATGAYEPKGFSPDFAVPQGAQEADGASLPRVVREQIGKGADWIKVYADYRWGPNGRTEPTFSVDELKLIVQTAASSGRSTAAHATSAAGMQRASEAGFTTIEHGDEGTAAVFDQMARQKIALCPTLAASEAVERYRGYRPGTDAEPEALVRKRASFQAALKAGVTICNGSDVGVFSHGDNARELELMVAYGMTPAQALLSATSVNARLLNQSAQIGAIKAGLLADLVAVQGDPTRDIGALRRVVFVMKNGQIYRSPAAGDRE
>NC_022600.1|WP_023173342.1|2075531_2076623_-|undecaprenyldiphospho-muramoylpentapeptide-beta-N-acetylglucosaminyltransferase
MNKPRLLIAASGTGGHIFPALAVAAQLSGEFEIAWLGVPDRLETKLVPERYRLHTVRLQGLNRRPGPQWLSAASQLLGAYRFARRLLKAEGFSGVFTTGGYIAAPAVLAARALGLPAVGHESNALPGKVTRTLARWMACLGLGFAEAAEYIPGIRSRWVGTPVREEFLRSPNPLLEIDVPPEAPLIVVLGGSQGARAINQLVVECAPGWLARGWQIVHVSGAGEFEAVRSRAPVHPAYHLYPFWEKMAPLLARADLAISRAGAATLSELLVSGTPAVLIPFPYAAEDHQRINAEVLVRSGAALHLPQATLNGPLLDRTVAALFADADILPRMARSARALAVPDAASRTADLVRECLGLRTPVG
>NC_022600.1|WP_041243855.1|2076744_2078049_+|SpoIIE-family-protein-phosphatase
MSTSPLPKIPAEPGQSPPSLTLMELASQLSREQRKIQDLLSSLGFALRSLSNLNQLLELIPLMAARVTDAEAGAVVLFAEDNQLGLVKLYCPDANWQPSLEALLEPLRELHADQAAAIEAKLASDPWVVAQNTSILVKSALRGRLYVFSRVANYHWTEGRQKLLRLVADQTAVAVENDTLNKELQRKEKLDRELEIGSEIQAQLLPRSCPRIEGIRLAARCLSADKVGGDYYDFIPIIHTNRWGIVIGDVMGKGVPAGLLMTMTRGMLRAEVLRKDPPALILEHLNHVMYADLENSNRFVTLFYSEYDPTTRTLHYSNAAHNPPLYWSAHTQEVHLLDTQGMLIGLEPGSLYQQQSQQLNAGDVVIYYTDGFTDAADRDSHRFGEQGLNQAVRWAVTHCESPEQILEYLFEQLRQFCPNGHCGDDMTLIVLKAE
>NC_022600.1|WP_023173344.1|2078116_2079700_+|Na+/solute-symporter
MQLNGLDWAIIGIYVAMLLSIGWSLRKFAQQGLENYFLGGRNLPGWLNGLSYASTCLNADVAPFYCGLAVATGLYAGWFYIARFGWALLIGGVLFAVFWRRLKIFTAPEFYELRFQGWGASWMRGWIAFRSAFIAIVAWTGAGLLGMTKVITPIFGIGRVETMLAVVPVILVYLYFSGYLGVVITDAIQSLFILLGSTALLIAVLVDFGGPTGLGSAIAQHFPQAMSSLPPAHDKFVSLFAVVAFTFGTSVGYGGDACPLGGAMEGQRILSSRDGREASRMYLWTELALFLFLLTLTLPALGAMVIWPGLRDGSIDQELAYGMLIHKYIPSGLLGLVLVSVVASLMSTVSSNLNFGAQVAINDIYRRYLRPDKSEAHYLKMGKLVSLLILVLSFSVVFGVNQLLDIAVFMIGLSAAELPANWAQWWWWRFNTRARLAASIGGPVIYLLVRYVLLPQQDFAVWILAAMALTTALWVSVALLTPPDDEAILERFYARAQPLGWWGPIARRLRTVSTSAGEQPQVLIQEE
>NC_022600.1|WP_023173345.1|2079989_2081156_+|ImmA/IrrE-family-metallo-endopeptidase
MNTRVHFAERLRSAREFARMSQTEAAAAIGLTSAALSQYEAGKRRVDALILEQLARLYAVPVGYFFGQAVSTPDWETALRDLSKTLSPAGRTGIARLIEKIRLLLELLRLTGAPRPKPPHHPFDALAEKEIAQKQIAVFAERVRRHYDLGVAPILNIRAWLEAEGYQVFALSLGQDPDDLSGFFFWHPELGPVVVVNADQSYSRWPFTLAHELAHSLFHYDRPAVLCRQVDQRPLERFADQFASSFLVPQEALLIRLQALNTAHIDTPEQIVHLSRYFGVSYKAMLRCLEQGDYLGRAPAALSDGVKPIVLARALGYGPTKLEFGTRPIPIEETLPRLFIELAYRAVREEKLSLRGAADRLGISDIELEERLFLEDAQSPEEGCAEMV
>NC_022600.1|WP_023173346.1|2081236_2081836_+|hypothetical-protein
MSFAHHQGIAILLTALGVERACFPAEVYNCDEDTRPLEAQDEDLSEFARGIRFAKRKAKEEPPGRELQYSTWLRNFEQLQPLMDAGTLFIEPLLLKELPRRQQFIEDYGLGRGESACLVLAERYRQLPGIFLSSDEAASKVAAKISLLHLSLVDVLLGWARTTRPDVELMEELVAGMQAARFGLKADIIQRLRSLSSEL
>NC_022600.1|WP_041244601.1|2082004_2082520_+|MgtC/SapB-family-protein
MALSEIIFRLGAAVLAGSAIGLNRNLRGKSAGLRTHALVCLGSALITLAGIELSGADTGAVLRVVQGVITGIGFLGAGVILRSQKAKRVLGLTTAATIWLAACFGIACGAGEWTLVLVALVLTLVVLVLGGPFERLIDGVILRVTGQKVVRTDTQPAGTQPSTDTADVQSR
>NC_022600.1|WP_023173348.1|2082526_2084701_-|S9-family-peptidase
MNTRLLGRTALALSAALFFLSALPPLFAAPPRRAITEKDLLKFNWIADPRLSPDGSQVVFVRVNVDEKKDTYTTSLWAVSTGNGALRQLSNGPRDTAPRWSPDGRSLVFLRSLDKDSKPAPPQLYFLSLEGGEARALSDLPKGVSEPAWSPDGRHIAFVSSTTAKDLEKKKAQKEDQDDKESDVRVVKEALYRINGAGYIDFDRPDHLWTVELSDQSSLPVPKQLTAGDFAENNPAWSPDGRSIYFSSDRTYESYYQPPNQDVYAVSAAGGPIQRVADIDGPIGDFAISPDGRRIAFVGFLNARPTRSYNQPDLFVASLEANATARNLTADYDYDIGDGLTADQHPPRGGGATDPIWSGDGREIVLVSVERGRANLKRFDVATGKISELTTGNQEVLSYSATPDGSKIALTLSTPASIGDLFWITNGSKPKPLTRLNQELFSQLDLGEPEEITYTSFDGKPIQAWVQKPPGFDPSKKYPLILNIHGGPHAAYGTTFFHEMQWMAARGYVVLYPNPRGSTSYGQDFGNIIQYHYPGDDAKDLLAGVDLLIARGYIDPDRLGVTGGSGGGILTNWIVGHTDRFKAAVSQRSISDWRDFWYTADFTLFTPFWFRGAPWQEEADFKARSPISFVENIKTPLMLIEGESDLRTPPAAGGEQLFRALKYLKRPTVMVRFPGETHELSRSGKPSHRIERLQHIVGWFDRYLLDKPMPIYDPPGTAATRDIR

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Crispr_ID: NC_022600_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022600_3

2486198-2486962

TypeIII

Consensus_repeat	Method
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCGAAC	CRISPRCasFinder
GTTTCCGTCCCCTCGCGGGGATTAGNGTCCACTC	CRT
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCGAAC	PILER-CR

9 spacers

csm6,csm3gr7,csx19,cas10,csx3,WYL,c2c9_V-U4

The CRISPR arrays of NC_022600_3

>merge|NC_022600|3|2486198-2486962|CRISPRCasFinder,CRT,PILER-CR
GTATCCATCCCCTCGCGGGGATTAGATCCACTCGAACTTCACATCCAGCAGCACCACCCGGCCCTGCTGGGCTACGACCGTGCAGCACACAACCGGGCGTATCCGTCCCCTCGCGGGGATTAGGTCCACTCGAACGAAAGACAATGACCAACTCCAGCAGCAAGTTATCGAAGTTTCCGTCCCCTCGCGGGGATGTAGGTCCACTCAAACCGCAATGGCTGAACGACTGTTGCACAAACAGCTGGTCGAGGCTGCGCGCGGTGTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCAAACTTTGGCATTCAATATAATTTTCGCTATTCTGAATGGCGAGTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCAAACTTCTTCGTGCTGAAAAGGAGTGCTTGTCTGATGATCTGGCGAGTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCAAACATGGTGAATGCGCCATTGTCCGACGCTGAAGCGTTGATGTGTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCGAACGCGGTGAAGTTGTTCGAATCCGGCAACGCCTGCCAGGTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCGAACGAGGGTCGCCTCCGGGCCTTTCTGGAAGAATGGGACATCAAGTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCGAACACCCACAACGGCGATCAGTTGCCCGTGCGCTACCTGGGCGGCAAACGTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCGAAC

>NC_022600|3|3|2486198-2486962|CRISPRCasFinder
GTATCCATCCCCTCGCGGGGATTAGATCCACTCGAAC	TTCACATCCAGCAGCACCACCCGGCCCTGCTGGGCTACGACCGTGCAGCACACAACCGGGC
GTATCCGTCCCCTCGCGGGGATTAGGTCCACTCGAAC	GAAAGACAATGACCAACTCCAGCAGCAAGTTATCGAA
GTTTCCGTCCCCTCGCGGGGATGTAGGTCCACTCAAA	CCGCAATGGCTGAACGACTGTTGCACAAACAGCTGGTCGAGGCTGCGCGCGGT
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCAAAC	TTTGGCATTCAATATAATTTTCGCTATTCTGAATGGCGA
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCAAAC	TTCTTCGTGCTGAAAAGGAGTGCTTGTCTGATGATCTGGCGA
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCAAAC	ATGGTGAATGCGCCATTGTCCGACGCTGAAGCGTTGATGT
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCGAAC	GCGGTGAAGTTGTTCGAATCCGGCAACGCCTGCCAG
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCGAAC	GAGGGTCGCCTCCGGGCCTTTCTGGAAGAATGGGACATCAA
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCGAAC	ACCCACAACGGCGATCAGTTGCCCGTGCGCTACCTGGGCGGCAAAC
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTCGAAC

>NC_022600|3|2|2486198-2486958|CRT
GTATCCATCCCCTCGCGGGGATTAGATCCACTC	GAACTTCACATCCAGCAGCACCACCCGGCCCTGCTGGGCTACGACCGTGCAGCACACAACCGGGC
GTATCCGTCCCCTCGCGGGGATTAGGTCCACTC	GAACGAAAGACAATGACCAACTCCAGCAGCAAGTTATCGAA
GTTTCCGTCCCCTCGCGGGGATGTAGGTCCACT	CAAACCGCAATGGCTGAACGACTGTTGCACAAACAGCTGGTCGAGGCTGCGCGCGGT
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTC	AAACTTTGGCATTCAATATAATTTTCGCTATTCTGAATGGCGA
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTC	AAACTTCTTCGTGCTGAAAAGGAGTGCTTGTCTGATGATCTGGCGA
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTC	AAACATGGTGAATGCGCCATTGTCCGACGCTGAAGCGTTGATGT
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTC	GAACGCGGTGAAGTTGTTCGAATCCGGCAACGCCTGCCAG
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTC	GAACGAGGGTCGCCTCCGGGCCTTTCTGGAAGAATGGGACATCAA
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTC	GAACACCCACAACGGCGATCAGTTGCCCGTGCGCTACCTGGGCGGCAAAC
GTTTCCGTCCCCTCGCGGGGATTAGGTCCACTC

>NC_022600|3|4|2486296-2486962|PILER-CR
GTATCCGTCCCCTCGCGGGGATTAGGTCCACTCGAACG	AAAGACAATGACCAACTCCAGCAGCAAGTTATCGAAG
TTTCCGTCCCCTCGCGGGGATGTAGGTCCACTCAAACC	GCAATGGCTGAACGACTGTTGCACAAACAGCTGGTCGAGGCTGCGCGCGGTG
TTTCCGTCCCCTCGCGGGGATTAGGTCCACTCAAACTT	TGGCATTCAATATAATTTTCGCTATTCTGAATGGCGAGT
TTCCGTCCCCTCGCGGGGATTAGGTCCACTCAAACTTC	TTCGTGCTGAAAAGGAGTGCTTGTCTGATGATCTGGCGAGTT
TCCGTCCCCTCGCGGGGATTAGGTCCACTCAAACATGG	TGAATGCGCCATTGTCCGACGCTGAAGCGTTGATGTGTTT
CCGTCCCCTCGCGGGGATTAGGTCCACTCGAACGCGGT	GAAGTTGTTCGAATCCGGCAACGCCTGCCAGGTTTC
CGTCCCCTCGCGGGGATTAGGTCCACTCGAACGAGGGT	CGCCTCCGGGCCTTTCTGGAAGAATGGGACATCAAGTTTCC
GTCCCCTCGCGGGGATTAGGTCCACTCGAACACCCACA	ACGGCGATCAGTTGCCCGTGCGCTACCTGGGCGGCAAACGTTTCCG
TCCCCTCGCGGGGATTAGGTCCACTCGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022600.1\|WP_023173787.1\|2492234_2493719_-\|TldD/PmbA-family-protein	unknown	unknown	gnl\|CDD\|223389
NC_022600.1\|WP_023173789.1\|2494137_2495433_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|180954
NC_022600.1\|WP_041243907.1\|2474380_2475316_+\|CRISPR-associated-protein-Csx3	csx3	mkCas0115_csx3_CAS-I:CAS-III	gnl\|CDD\|370583
NC_022600.1\|WP_023173786.1\|2491758_2492223_-\|RpiB/LacA/LacB-family-sugar-phosphate-isomerase	unknown	unknown	gnl\|CDD\|376799
NC_022600.1\|WP_023173783.1\|2487467_2490146_+\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341064
NC_022600.1\|WP_023173781.1\|2485304_2486153_+\|DUF1186-domain-containing-protein	unknown	unknown	unknown
NC_022600.1\|WP_023173785.1\|2490385_2491666_-\|transposase	c2c9_V-U4	-	gnl\|CDD\|223747
NC_022600.1\|WP_023173791.1\|2496348_2496549_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023173769.1\|2472889_2474278_-\|TIGR03985-family-CRISPR-associated-protein	WYL	mkCas0075_WYL_CAS-I:CAS-III	gnl\|CDD\|274901
NC_022600.1\|WP_023173772.1\|2475409_2477155_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|187811
NC_022600.1\|WP_023173775.1\|2479674_2481189_+\|hypothetical-protein	csm3gr7	cd09726_csm3gr7_CAS-III-D	gnl\|CDD\|187857
NC_022600.1\|WP_023173793.1\|2497152_2497512_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|180986
NC_022600.1\|WP_081705227.1\|2472448_2472832_+\|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl\|CDD\|198403
NC_022600.1\|WP_023173792.1\|2496682_2497135_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|223702
NC_022600.1\|WP_023173777.1\|2481185_2481755_+\|hypothetical-protein	csx19	cls001376_csx19_CAS-III-D	gnl\|CDD\|274900
NC_022600.1\|WP_023173788.1\|2493928_2494072_+\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023173779.1\|2481751_2483884_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NC_022600.1\|WP_023173780.1\|2483998_2485111_+\|putative-CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
NC_022600.1\|WP_051382797.1\|2495504_2496293_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|130358
NC_022600.1\|WP_051382795.1\|2477174_2479685_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187857

Protein	Function_ID	Function_description	E-value
NC_022600.1\|WP_023173787.1\|2492234_2493719_-\|TldD/PmbA-family-protein	gnl\|CDD\|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	3.30958e-99
NC_022600.1\|WP_041243907.1\|2474380_2475316_+\|CRISPR-associated-protein-Csx3	gnl\|CDD\|370583	pfam09620, Cas_csx3, CRISPR-associated protein (Cas_csx3). This entry is encoded in CRISPR-associated (cas) gene clusters, near CRISPR repeats, in the genomes of several different thermophiles: Archaeoglobus fulgidus (archaeal), Aquifex aeolicus (Aquificae), Dictyoglomus thermophilum (Dictyoglomi), and a thermophilic Synechococcus (Cyanobacteria). It is not yet assigned to a specific CRISPR/cas subtype (hence the x designation csx3).	5.29342e-33
NC_022600.1\|WP_023173786.1\|2491758_2492223_-\|RpiB/LacA/LacB-family-sugar-phosphate-isomerase	gnl\|CDD\|376799	pfam02502, LacAB_rpiB, Ribose/Galactose Isomerase. This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).	1.28071e-41
NC_022600.1\|WP_023173783.1\|2487467_2490146_+\|M1-family-metallopeptidase	gnl\|CDD\|341064	cd09601, M1_APN-Q_like, Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1). This M1 peptidase family includes eukaryotic and bacterial members: the catalytic domains of aminopeptidase N (APN), aminopeptidase Q (APQ, laeverin), endoplasmic reticulum aminopeptidase 1 (ERAP1) as well as tricorn interacting factor F3. Aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease, preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is considered a marker of differentiation since it is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. ERAP1, also known as endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP), adipocyte derived leucine aminopeptidase (A-LAP), or aminopeptidase regulating tumor necrosis factor receptor I (THFRI) shedding (ARTS-1), associates with the closely related ER aminopeptidase ERAP2, for the final trimming of peptides within the ER for presentation by MHC class I molecules. ERAP1 is associated with ankylosing spondylitis (AS), an inflammatory arthritis that predominantly affects the spine. ERAP1 also aids in the shedding of membrane-bound cytokine receptors. The tricorn interacting factor F3, together with factors F1 and F2, degrades the tricorn protease products, producing free amino acids, thus completing the proteasomal degradation pathway. F3 is homologous to F2, but not F1, and shows a strong preference for glutamate in the P1' position. APQ, also known as laeverin, is specifically expressed in human embryo-derived extravillous trophoblasts (EVTs) that invade the uterus during early placentation. It cleaves the N-terminal amino acid of various peptides such as angiotensin III, endokinin C, and kisspeptin-10, all expressed in the placenta in large quantities. APN is a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs are also putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	0
NC_022600.1\|WP_023173789.1\|2494137_2495433_+\|adenylosuccinate-lyase	gnl\|CDD\|180954	PRK07380, PRK07380, adenylosuccinate lyase; Provisional.	0
NC_022600.1\|WP_023173785.1\|2490385_2491666_-\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.19281e-34
NC_022600.1\|WP_023173769.1\|2472889_2474278_-\|TIGR03985-family-CRISPR-associated-protein	gnl\|CDD\|274901	TIGR03985, hypothetical_protein_sll7078, CRISPR-associated protein, TIGR03985 family. Members of this protein family belong to CRISPR-associated (Cas) gene clusters. The majority of members are Cyanobacterial.	3.62221e-109
NC_022600.1\|WP_023173772.1\|2475409_2477155_+\|hypothetical-protein	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	8.94422e-05
NC_022600.1\|WP_023173775.1\|2479674_2481189_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	4.60802e-18
NC_022600.1\|WP_023173793.1\|2497152_2497512_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|180986	PRK07459, PRK07459, single-stranded DNA-binding protein; Provisional.	1.18223e-64
NC_022600.1\|WP_081705227.1\|2472448_2472832_+\|GIY-YIG-nuclease-family-protein	gnl\|CDD\|198403	cd10456, GIY-YIG_UPF0213, The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1. This family contains a group of uncharacterized proteins found mainly in bacteria and several in dsDNA viruses. Although their function roles have not been recognized, these proteins show significant sequence similarities with the N-terminal GIY-YIG endonuclease domain of structure-specific endonuclease subunit SLX1, which binds another structure-specific endonuclease subunit SLX4 to form an active heterodimeric SLX1-SLX4 complex. This complex functions as a 5' flap endonuclease in yeast, and has also been identified as a Holliday junction resolvase in human.	3.93079e-28
NC_022600.1\|WP_023173777.1\|2481185_2481755_+\|hypothetical-protein	gnl\|CDD\|274900	TIGR03984, hypothetical_protein_FrEUN1fDRAFT_5778, CRISPR-associated protein, TIGR03984 family. Members of this protein family are found exclusively in CRISPR-containing organisms, in operon contexts with RAMP (repeat-associated mystery protein) proteins also linked to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats).	3.66946e-26
NC_022600.1\|WP_023173792.1\|2496682_2497135_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|223702	COG0629, Ssb, Single-stranded DNA-binding protein [DNA replication, recombination, and repair].	1.56835e-18
NC_022600.1\|WP_023173779.1\|2481751_2483884_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	2.20623e-101
NC_022600.1\|WP_023173780.1\|2483998_2485111_+\|putative-CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	7.3793e-43
NC_022600.1\|WP_051382797.1\|2495504_2496293_+\|ABC-transporter-permease	gnl\|CDD\|130358	TIGR01291, Nodulation_protein_J, ABC-2 type transporter, NodJ family. Nearly all members of this subfamily are NodJ which, together with NodI (TIGR01288), acts to export a variety of modified carbohydrate molecules as signals to plant hosts to establish root nodules. The seed alignment includes a highly divergent member from Azorhizobium caulinodans that is, nonetheless, associated with nodulation. This model is designated as subfamily in part because not all sequences derived from the last common ancestral sequence of Rhizobium sp. and Azorhizobium caulinodans NodJ are necessarily nodulation proteins. [Cellular processes, Other, Transport and binding proteins, Other].	2.57373e-34
NC_022600.1\|WP_051382795.1\|2477174_2479685_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	1.69179e-15

>NC_022600.1|WP_023173781.1|2485304_2486153_+|DUF1186-domain-containing-protein
MAETDEDLKGLGGRGEGYSAVVAQLLRLETPEAMEGLPDGDYRALGLGEAHVDELRAFAREYAPLRLDSKNWNSPEYWAAAHAWRALTQIDIEAAVETMLDLLPRLADDEWLHSDFLEVAQRIGPAQLPRLRAFLEEEANAPASDAVTTAQTLIAEQHPEARDEVVAALVQILERAKTNSEWLNAVLIDGLIRLKAVEAADVIERAYAADAVDPIFVGDWEDVQVELGLKDRPPSGQSSPLLPRVSNRSHLEPSGTSKKSVSASRRQMQKQSRKQNRKSKRK
>NC_022600.1|WP_023173780.1|2483998_2485111_+|putative-CRISPR-associated-protein
MKDTLICTVGTSLLGNLKRAADQKLQNAYTSENWPEVLSLLKKLSVDAKICGAEINSTAAIVSRNYLDHCQRLILLYSDTPDGENVGKLLQSYFDSSKELAFKEVSARPLKGLTDRDVRSFQNKGLLSLVQEISELVRKYGLESVLINATGGYKAQISFAGMIGQAFDIPVFYLFENFSEIIELPPQPIALDLSLWLENYAAFEQIEEAEGELTFLEDLPLDIQQQVPALMFNLTPEGGKHFIELTAMGYLFHERCRLQFQRQETTLLNRIPQTDLLPERKRIDLRDDHGNDLLMKISKKLCQSPYVIEVVNSLPWNPKATKPIRRTTHNGLIDFVMVHTDRGLGVCLRTTGRTRVETNTIAAHLADRYG
>NC_022600.1|WP_023173779.1|2481751_2483884_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MTHSRFHNPYNFVPAPPRRLGDRHLGDAIPPSHHRLHPDRYSGRIAVTLTTVTPLLLLDTARVSENDQTKHKTYPLRLGADGRPYLPPTSLKGMLRSAYEAVTNSRLSVFFGHDKRLAYRMPARDGLSLVPVRIEGNQIQILLGTNNNLPALHNGHWQIPNSVMYAAWLPRYDTSTGEVSAATAVGFAGMQHGDLAGAWLEEIERLPRSPRQRPFKYWRVRKLVRAGENLGRAPQPSRPSRYHVPTGRPMREQKGYVCLTGGTGNPPKHNIDGKHDERLFFSTADPLPVAPLTADLKTQWRELIRNYQSIHAEERRQNRSGPPALAHSHWSRQVVGGESETELKTGTLCYAAVDRDHEGRYGVYALYPVMISRALYDAAPIDLLDASLHPATALQELSPAERVFGWVNQDGTGSYRGNLRIGPVTCTADDAAERFAIPGVPLAILGQPKPQQIRFYVAEDVAGRALQANTPKEDGYMHPYERIKRSLRGRKVYPHHANLSQNYWNSPTQDRTQRELQEYRRPENGTEPRDDQNRSILGWVKPERQFRFDIDITNLSEVELGALLWLLDLPERHYHRLGGGKPLGFGSVRLSIDWSGTDLRTGTGWSEYYADLLAQTTSSLAATTGPVAAFKKAVASTYGNSQPFERVRFIAAFLRSAQGYGDGLPIYYPRITPHANPAGESYRWFTANEDPKRRKSLPDLADGPHGLNLP
>NC_022600.1|WP_023173777.1|2481185_2481755_+|hypothetical-protein
MSERVLHGRTSNNLSLAEALTNCAAPLTGAIALLYSSNACTFARFEDGLLIDAGGDIDLTPVFEARVFNEACELRWLNTHDGQGRAVLLSETQQNGLEEDIMPLHFLEALPGTYLLWGEQIDSDLATGWSRVGRSRMGAIAIPLAPLPKGACVYLQVREYLGEIGDHGNVAVVEECLTGLSLKPPGATA
>NC_022600.1|WP_023173775.1|2479674_2481189_+|hypothetical-protein
MARKVKTRVRLEGELVARTALHVGGMGGDADVDLALAVNGNGTHYIPGTSLAGVLRSWFEHFDGGTDHFWGPRTSRERPEEGHASLVIVEDAPINGRVETEIRNGVGIDRQTGTAATGIKYDRGVLPRGTRIPLRVTIDFTDEATWEAASDSWFALLEALKRGQVRFGAGKTRGLGRVQLDAPSVKVQQLSTRAGMLAALKDGGESVSFETLPAPAKHSTRPWLTFTVHWRPLGPLMVKSGVDGLAVDMLPLVSAVGLDAVRFCLPGSAIKGTLRSWCERLVCTLLDRPEVQERNSGSRFLAQVEQPLVKHLFGSANTYRAAGVLSVDDCYAINQIAADQWNAIETATSDGSLQSALRTSGLDGRLQQSYHVAIDRWTGGAADSMLFTVLEPHALTWEPLRFDLDLDSKRLDGSLQFPILALLLLMLRDLGKNRIPLGFAALRGMGAVAVERVEIEGSGLPTELSGLQEATLVVGDFAALDYKLLTTLQTAWKNWIDQQSEEAP
>NC_022600.1|WP_051382795.1|2477174_2479685_+|hypothetical-protein
MSRKNKRKNRQNQGNSATRSNSSPASQARSQANSPPGGGSAERPSPTLPIDFVLKVKMLSDWHVGAGYGRPGDIDRLVRRDHEDLPFLPAKTLTGIWRDGCELVACGLDDGNKNGPWSRWVEYLFGDQPALAEQASGLAPVGAALSVRPARLDPALRRVLTERRALLEGLTFVKPGVAIDAATGTAKDDFLRFEEMVRQGAVLQAECSLNAIASKKGREVALALLAAGAKMVERLGGKRRRGNGRCEFTLHHPETEGWLAVLESTEDPGPPPEPMPWPPADGTAADEPTSGGSWQRLVLNIEARTPLVIAARTVGNVVETLDYIPGTLLLPIVSRRLQQLGVPLGAAIVRGDLVVTPATLAVNKERGQPVPNALFERKGSKGFEQEGNLFNRFEENIGGQLKGCRAGYLGRTDAAHLPVLGKISLRLQTHNTVADDRQRPDESVGGVYSYEAIPAGTRFLAELRLRTELAERLKAKQANWSTLLGGTERVGQAKKDDYGQIQISCAGKFTPFPARSEQPSQAPSTLTVWLLSDLLLRDERLRPSTTVETLRSALEAELGVKLLVEGESAFTRQRRTESWHTRWNLPRPSLAGLQAGSCVRFSIKDGQIRLEDLTRLEAGGLGERRAEGYGQLSFDDPLLSTKLSELTALQEQASESPKNKLALINAQNHDLYAYARQIEQEVWRANLRRVVLAVAASPEKRKDLLGFSLEDQGGKPPSSQLGALRSVLVACARNNLELFNQWRSRLENSSNHRERWPECSLERLSELVNDPARIWQVLSGPESEGRLSLEELVCTSDGLNRLKNELRFEAVRMLVDACIRAHRREVEQQEETPHGS
>NC_022600.1|WP_023173772.1|2475409_2477155_+|hypothetical-protein
MYLTLLETSGNQNYIFSTNKLKENFGASELTYLAGTRWVLEAVAEAGGPALWSDDPARLRRNLLDSSLNRAIESSESVAVEVIVATSGKALLLTQTPQTAKALVRETTARALREAPGLDLFGVSRQFDWDRDLLGEVNRCVHRAFEAERASHPGPMLRSLRLPVIDECATSGLPANIRVLNPQDRFEPISRSSHAKAGAGPGAFKRIERLLRNAPEGSRLPDNLRVLEDRFDRLEWLGVVHADGNGLGEIFLRFHKHIEACTAGDNRRYVEQLRRFSLALDRCTEQAFLEAASILAPDLAPDRRDRFLPLVPLVLGGDDLTVICDGRQALEFTHKFLCAFEDYTASERLGDDLYRGIVPELAKKALGQPRLSACAGVAIVKRHFPFSLAYDLAADLIKEAKKVKSKIHQPGKPTEPWPSSALDFHVLYDSSAVKLDDIRGRLAVDKGKTVLHSRPFVVTPRELLEGATGFDWAEQHRIECLKDRIAALNKPGAVNKPSEDGRRALPNSQMHQLRSGLFLGYEQADARFRLIYHRYAKQGLSKFNQSGDEQVPSLFRVESDGVRSTALLDALDAAAFYGASS
>NC_022600.1|WP_041243907.1|2474380_2475316_+|CRISPR-associated-protein-Csx3
MDLQAATFDLSVPRHWHGLHLQVLEIRLLRPDRRLEPEDLPRLLLPEPVHGVGLVISGRGPLWLYGHLVHRYHSAAWIAIYDPRLGAVVVESHVPGAYLGQVLPFEAMPPNIPRPHPPVLAPAVLVVGPPDSGKSVLAHALFQVLLTECPEVFLQRANWDGEGNYLLELGPETTPIRTNAFAAANKGTMSAGFFGYHAEAILHLRRQKALVIVDVGGMVQPEKQPLLEACSHYLIVSSRPEAVEAWHTFCRDRGNLVPVAVVHSTLNPSEIIHQRTPFLELTCGPLRRGTPVPIPAMLLDRLRSLLFPSHS
>NC_022600.1|WP_023173769.1|2472889_2474278_-|TIGR03985-family-CRISPR-associated-protein
MFFEYAPDAAVLDALAGGQLAGRMLRAVRLWWILRLLYGDGNHGSAPGNLFNAPRLMKCLYAPGHDWGERRTSDGTSCPGCLCTLSLEALLHRFDADLPVETWCLEVSRRTGLAPELLRRYLKKRPFAIVARSLRDDLQHLCRLGWLQRDGASGLYRRRLVEEFPRLLPEEQSAVPAVYRRSVAQALQTVQFAYPQLYALVNEWQGDDDTDRRIFVEFDYILSEEDAERVDDYQEQLRGWWEAGDLRPVTFAYTLSTDRKVQICVYPVCLHYVRRAKYLSAYGLGPEGHIGWHNYRLDRIASTTLKPLDWADPQVPVALHSCRQDGNLPTPAYVRKALNEAWGFNFYLPAALLLLRFPADYAARWLANTHRHPTFGPIPYAQLPSLIRRHYSDSREQQPMLALVARRPTSDAYYKALVRLGDTNLTLRLREWRPHGEVLAPLALRRQMAEEVRLELHHYADL
>NC_022600.1|WP_081705227.1|2472448_2472832_+|GIY-YIG-nuclease-family-protein
MDHHSQGRDEVQSQFATAGDRLATTDEPIAQVTVYLVRCRNGALYCGQTSDLARRLELHASGKGARFVRMAGFASLAAAWPVEDRSAALRLEAAVKRLGKATKEALVIDPGATVLLAAKLGIRLVNN
>NC_022600.1|WP_023173783.1|2487467_2490146_+|M1-family-metallopeptidase
MLSRPLVYLLAGLAWALSLVGPVRAEPKFAFENTPGQLPKEVVPQSYAIAITPDPKSLTFRGSETITVKVRKATRTITLNALNLQITNVRLDDQTDGTISIDPDRQTASFDFPQDIPAGIHKLALDFAGRANLQAEGLYYVRYQTNEGGKVMFGTQMEPTDARRMFPLWDEPVFRASFQLSVTLPQSMSAVSNMPVEREEPLGSGLKTVRFAPTPPMASYLVVLCAGEFESLKDTVDGIDISVVTTKGKKETGRYALEVLKQILPYYNDYFGVKYPLPKLDMIAVPGGFSGAMENWGGITYNEAILLFDPAHSTQQTREAIYGVVAHEVAHQWFGDLVTMAWWDNLWLNEGFASWMSAKATDHFNPDWQIWLRSSGSKNTAMLFDARRTTHPIQQPVTNPAEAASAFDEITYQKGQAVLRMFESYLGEDRFRAGIRAYMAAHQFANTTTADLWEALGQASGQPVSSIAAGWTEQPGFPLLSVEGNCHASRYNLTLNQSRFTINDPKAQPLLWQIPITYGQGLPADNQNYLLAAKTGALMSASCRLPLKFNLGDTGYYRVRYAPTLFKALKQRFTQLPAADRVNLLSDSWAAVQANQARASDYLALVNVAKGDSELAVWQQILGSLNEIDRLEIGRPGRIPFQGYARTLLEPVYRRVGWDAAPGEAGTTSLLRTSVLTALGRFKDESVIREAQRRFQVFLKAPDSLPPNLRPAVFNTVGRYADSGTYEALLTLGRKTTSTEEKRLYYGALAGALDPKLAQRTLALALSDELEPNLATNLVQTVAERGEQPELAWEFAQKHYQPLLEKLAFFRRYRYLPNLVANFSDAEFAQQLEDFARAHLPADAQAEVRKGVESVRASASIKQKQLTNIDRYACDQSKTPGQRTPQVCVGVE
>NC_022600.1|WP_023173785.1|2490385_2491666_-|transposase
MLLAYQYKLLPTYEQRCRMDKWLDMLRHQYNYLLAERFDWYERNRCSINACPLLCHLPKLKEPPNYYSQKRSLVPLKQEREWYKDIHAHVLQDMVKRVELAFARYLKGDSKANRSGKPRFKGKGRYRTFTFPQLSAQPFMGNRIALPKLGKVKLTQHRPIPDGFFIKTASVTKKPDGWYVQLVLEDVSVPDAPSINIVPTEANSMGVDAGLEYFVACSDGFTNESPKFLRKAEEKLAKLQVKFALRKKGSKACRKLGQRIGRLHQTIARTRRQWHFETAGELLDRADVLFVEDLKVSNLSCRCKPKQDEEGRFLANGQSAKSGLNKSFADAGVARFLNEILPYKAEKAGKQVIKVNPAGTSQHCAKCLKRVPKQLSDRWHSCPHCGVELSRDVNSGMLIKKVGLGVRLTIKRESRKAGEARALSVG
>NC_022600.1|WP_023173786.1|2491758_2492223_-|RpiB/LacA/LacB-family-sugar-phosphate-isomerase
MKIAVGSDEKNYLTDALVQELEGRGHELLLIGPLAGTGDAWPAVGEAVGEAVGSGRSALGIVCCYTGTGVSIAANKVTGVRAALCGDAQTAAGARRWNDANVLALSLRTTTPDLLREILDAWFGTDCPASERVYVEQIRAIEEARNQSVRSLHL
>NC_022600.1|WP_023173787.1|2492234_2493719_-|TldD/PmbA-family-protein
MVQLAPLTQLDLAQLAVDLIYKAGCEYGDVRFASYRNQRLTASDRSLAELSDRTSSGFGVRVLWRGAWGFAASHRRTPEEVKRVVDLAVLTAQASRTTLKQPAQLVTAPVQQGHYTTPIRQDPFEVTVEEKARLLLELNERLLSFAHQGIRKARSFLRLGREEKLFINSEGTRIQQTLYRSYPGFSCTAVAEGDAQERSYERPPLNIGYEHVDAADLFSQVERVANEAIEKVRAPRASQGGRTHLILKPSHLFLTIHESVGHPTELDRVYGYEANFAGTSFATTDKLGHLRYAAPWVNFRADRTQPGGRATCGWDDEGVPAQEWLVVRDGLLVDYLTDRETAHRLGRPQSNGCAFADSWASVPMVRIPNLGLVPGAAEGSHTATLAQMIADTEAGILIDGIGSYSIDQQRRNFQFGGDAFWKIEKGKIVHMLKDVTYSAMTTDFWNSVDAIGPESECEQWGTDICGKGEPMQVAQMSHACVPVRVRNIEVGGPA
>NC_022600.1|WP_023173788.1|2493928_2494072_+|hypothetical-protein
MKSVEERSFDIEELKQYFFADRQPVEEFDLEAMRRHFDALLQRGAAR
>NC_022600.1|WP_023173789.1|2494137_2495433_+|adenylosuccinate-lyase
MIERYTLPEMGALWTEEQKYRNWLKVELAACEALAERGEIPPDAWEEIRSKAGFDLEHIAQIEAEVHHDVIAFLTSLGEKVGPASRFIHLGLTSSDVLDTALGLQMTQALDLIALRLADLVAVVRQRAGEHRDTVMIGRTHGIHAEPITFGFKLAGWLAELLRHAERLDALRPRIAVGKLSGAVGTYANIDPAIEARACQLLGLSPDAASTQVISRDRHAEFVQALALLAASIERFAVEIRNLQRTDVLEVEEYFARGQKGSSAMPHKRNPITAEQLTGLARLIRSNALAALENMPLWHERDISHSSVERVILPDSTILAHYMLVKFTALVERLQVYPDNMLANLNRYGGVVFSQRVLLALVGKGLSREHAYRIVQSNAHRAWNQMDGDFRALIAADSEVGQYLSEAELAQCFEPAHHLKHLPVVFERLSV
>NC_022600.1|WP_051382797.1|2495504_2496293_+|ABC-transporter-permease
MAKFAAGAISPWGVYSVWRRHAGVYRVTWLSNLLPPMTEPMLYLFAFGAGLGPMIGSFVYLEKTVTYPQFLGPGMIAVAVLFQSFFEGAYSSFVRLSFQKTWQALLTAPLSFTDVFLGDWLWAATKGVIGGLVTGLVVIAFGLYPPSALLFSLPILVLAALLFGACGLVTAGIVRTIDQVNLPTFLFILPMFTLCGTYFPRTNLPQAARWLAEALPLSAIVDFLRWPIGLQNYWPWQLGWLLVLGALAVSWAWRAIYRRIYL
>NC_022600.1|WP_023173791.1|2496348_2496549_-|hypothetical-protein
MNSYPSVSPFRLEFLLHLLITGGLLLTGLLAARQVQSLPLNTSRYSVDQTPVFDLPEVIVRPTHRR
>NC_022600.1|WP_023173792.1|2496682_2497135_-|single-stranded-DNA-binding-protein
MNTIALQGKLHSAPELRHTQDGLAQASALLSFAALKTDEADYTLRLVLFGNAAEEFCANFHQGDALIVEGRLQSEARPRPDGTKERVIELIARRCHALTPASTRPATAAPVPAPAQKTAAPSASRPTAARRPGNAPARPAVAVADDDIPF
>NC_022600.1|WP_023173793.1|2497152_2497512_-|single-stranded-DNA-binding-protein
MALLNQVNLVGRAGRDPEIRYFETGTVLCTLTLAVDRLRRKGTDEQPDWFDLEIWGKTAEIAGEYVRKGSLLGITGALTFSRWTDKTTQERRERPVIKVDQLELLGSRERRSGDSESFS

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Crispr_ID: NC_022600_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022600_4

2600618-2602373

Unclear

Consensus_repeat	Method
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CRISPRCasFinder
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CRT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	PILER-CR

24 spacers

cas3HD,cas6,WYL

The CRISPR arrays of NC_022600_4

>merge|NC_022600|4|2600618-2602373|CRISPRCasFinder,CRT,PILER-CR
GAGGTCTAATCAGTGACTCCTTTCGGAGTTGAGCACGAGAGTCCGACGGATGATTTTGCTGCACCTTCTTCGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACATTCACGCTCCTGCAAAGTATTGCCTGGGCCAACTGGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACCGGCCACCATCGACGCCATCGGATCTGCGACGGTGAGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACCAAACCAAGTACATGCTCAGACTCGGAAAACATGCTGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACCTCAGTGAATTGCTCATGATCTATCGAGGTCATGACGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACGCTTTTGCTGGAGTTTCGCACCTCGCTAACAATCCGAGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACGTTTTATTCCCGACGATTTATTATCAGCAATTAATGGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACAATTTGATCAAATCGCGGAATATCTGCAATACTTGATGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACTAGTAGTCCCGTCCGAACTCGACCGGCCCAGAGTAGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACACATTGGCCGCGCCGCTGTCCGCCGGCTCAGCGCTGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACATCCGCTTGTCCTGCGCCTCGACGAGCGTAGTCAGCTGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACTTTATTACAATCCGTATTCAAGTGCTACCGCTTAGGAGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACAGAACCAATCCGGCGGGTCTGAGATTTCCGATCGCACGATTCAATCAGTGGCTCCTTTCGGAGTTGAGCACTTTGGAGAGTAGAGATGCGCATTCCGAACGACTCGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACCAGATTGTTCTGCTCGAAACCGAGGAGCACCTTCGGGGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACAGCCACTGCCCGATTTCCCAATCCGACCACTCGCGGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACCCCAGACCGTGAGCATCTGGCGGGAGTACACGTTGGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACGGGTGGAAGCGGGCGCAGTGGACAACCTGGGCAAAGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACTTGCCAGTGTTGGTTTTTTCGGGCGTAAAGAGCACGTGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACGTGATAATACGGCGCAGGTTACGCGGCTTCTACTCGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACAGAACCAATCCGGCGGGTCTGAGATTTCCGATCGCACGATTCAATCAGTGGCTCCTTTCGGAGTTGAGCACTAGTGCTCTGGCGCGGAGTAGTCGAAAAGCGTGCGGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACTGCTTCTTGCAGACATTCCGGGGTTAGGAGAAAATCGCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCACCAGGAGACTGCAATCGCCGATCTTGATCGGGGGTGCGATTCAATCAGTGACTCTGATCAGGCAGGATGCC

>NC_022600|4|4|2600618-2602373|CRISPRCasFinder
GAGGTCTAATCAGTGACTCCTTTCGGAGTTGAGCAC	GAGAGTCCGACGGATGATTTTGCTGCACCTTCTTC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	ATTCACGCTCCTGCAAAGTATTGCCTGGGCCAACTG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CGGCCACCATCGACGCCATCGGATCTGCGACGGTGA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CAAACCAAGTACATGCTCAGACTCGGAAAACATGCT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CTCAGTGAATTGCTCATGATCTATCGAGGTCATGAC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GCTTTTGCTGGAGTTTCGCACCTCGCTAACAATCCGA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GTTTTATTCCCGACGATTTATTATCAGCAATTAATG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AATTTGATCAAATCGCGGAATATCTGCAATACTTGAT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TAGTAGTCCCGTCCGAACTCGACCGGCCCAGAGTA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	ACATTGGCCGCGCCGCTGTCCGCCGGCTCAGCGCT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	ATCCGCTTGTCCTGCGCCTCGACGAGCGTAGTCAGCT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TTTATTACAATCCGTATTCAAGTGCTACCGCTTAGGA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AGAACCAATCCGGCGGGTCTGAGATTTCCGATCGC
ACGATTCAATCAGTGGCTCCTTTCGGAGTTGAGCAC	TTTGGAGAGTAGAGATGCGCATTCCGAACGACTC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CAGATTGTTCTGCTCGAAACCGAGGAGCACCTTCGGG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AGCCACTGCCCGATTTCCCAATCCGACCACTCGCG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CCCAGACCGTGAGCATCTGGCGGGAGTACACGTTG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GGGTGGAAGCGGGCGCAGTGGACAACCTGGGCAAA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TTGCCAGTGTTGGTTTTTTCGGGCGTAAAGAGCACGT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GTGATAATACGGCGCAGGTTACGCGGCTTCTACTC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AGAACCAATCCGGCGGGTCTGAGATTTCCGATCGC
ACGATTCAATCAGTGGCTCCTTTCGGAGTTGAGCAC	TAGTGCTCTGGCGCGGAGTAGTCGAAAAGCGTGCG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TGCTTCTTGCAGACATTCCGGGGTTAGGAGAAAATC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CAGGAGACTGCAATCGCCGATCTTGATCGGGGGT
GCGATTCAATCAGTGACTCTGATCAGGCAGGATGCC

>NC_022600|4|3|2600618-2602373|CRT
GAGGTCTAATCAGTGACTCCTTTCGGAGTTGAGCAC	GAGAGTCCGACGGATGATTTTGCTGCACCTTCTTC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	ATTCACGCTCCTGCAAAGTATTGCCTGGGCCAACTG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CGGCCACCATCGACGCCATCGGATCTGCGACGGTGA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CAAACCAAGTACATGCTCAGACTCGGAAAACATGCT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CTCAGTGAATTGCTCATGATCTATCGAGGTCATGAC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GCTTTTGCTGGAGTTTCGCACCTCGCTAACAATCCGA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GTTTTATTCCCGACGATTTATTATCAGCAATTAATG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AATTTGATCAAATCGCGGAATATCTGCAATACTTGAT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TAGTAGTCCCGTCCGAACTCGACCGGCCCAGAGTA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	ACATTGGCCGCGCCGCTGTCCGCCGGCTCAGCGCT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	ATCCGCTTGTCCTGCGCCTCGACGAGCGTAGTCAGCT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TTTATTACAATCCGTATTCAAGTGCTACCGCTTAGGA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AGAACCAATCCGGCGGGTCTGAGATTTCCGATCGC
ACGATTCAATCAGTGGCTCCTTTCGGAGTTGAGCAC	TTTGGAGAGTAGAGATGCGCATTCCGAACGACTC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CAGATTGTTCTGCTCGAAACCGAGGAGCACCTTCGGG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AGCCACTGCCCGATTTCCCAATCCGACCACTCGCG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CCCAGACCGTGAGCATCTGGCGGGAGTACACGTTG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GGGTGGAAGCGGGCGCAGTGGACAACCTGGGCAAA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TTGCCAGTGTTGGTTTTTTCGGGCGTAAAGAGCACGT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GTGATAATACGGCGCAGGTTACGCGGCTTCTACTC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AGAACCAATCCGGCGGGTCTGAGATTTCCGATCGC
ACGATTCAATCAGTGGCTCCTTTCGGAGTTGAGCAC	TAGTGCTCTGGCGCGGAGTAGTCGAAAAGCGTGCG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TGCTTCTTGCAGACATTCCGGGGTTAGGAGAAAATC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CAGGAGACTGCAATCGCCGATCTTGATCGGGGGT
GCGATTCAATCAGTGACTCTGATCAGGCAGGATGCC

>NC_022600|4|5|2600689-2602303|PILER-CR
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	ATTCACGCTCCTGCAAAGTATTGCCTGGGCCAACTG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CGGCCACCATCGACGCCATCGGATCTGCGACGGTGA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CAAACCAAGTACATGCTCAGACTCGGAAAACATGCT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CTCAGTGAATTGCTCATGATCTATCGAGGTCATGAC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GCTTTTGCTGGAGTTTCGCACCTCGCTAACAATCCGA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GTTTTATTCCCGACGATTTATTATCAGCAATTAATG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AATTTGATCAAATCGCGGAATATCTGCAATACTTGAT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TAGTAGTCCCGTCCGAACTCGACCGGCCCAGAGTA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	ACATTGGCCGCGCCGCTGTCCGCCGGCTCAGCGCT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	ATCCGCTTGTCCTGCGCCTCGACGAGCGTAGTCAGCT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TTTATTACAATCCGTATTCAAGTGCTACCGCTTAGGA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AGAACCAATCCGGCGGGTCTGAGATTTCCGATCGC
ACGATTCAATCAGTGGCTCCTTTCGGAGTTGAGCAC	TTTGGAGAGTAGAGATGCGCATTCCGAACGACTC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CAGATTGTTCTGCTCGAAACCGAGGAGCACCTTCGGG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AGCCACTGCCCGATTTCCCAATCCGACCACTCGCG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	CCCAGACCGTGAGCATCTGGCGGGAGTACACGTTG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GGGTGGAAGCGGGCGCAGTGGACAACCTGGGCAAA
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TTGCCAGTGTTGGTTTTTTCGGGCGTAAAGAGCACGT
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	GTGATAATACGGCGCAGGTTACGCGGCTTCTACTC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	AGAACCAATCCGGCGGGTCTGAGATTTCCGATCGC
ACGATTCAATCAGTGGCTCCTTTCGGAGTTGAGCAC	TAGTGCTCTGGCGCGGAGTAGTCGAAAAGCGTGCG
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC	TGCTTCTTGCAGACATTCCGGGGTTAGGAGAAAATC
GCGATTCAATCAGTGACTCCTTTCGGAGTTGAGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022600.1\|WP_023173896.1\|2615569_2616721_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|376559
NC_022600.1\|WP_023173884.1\|2597275_2598025_+\|ATP-dependent-RNA-helicase	cas3HD	cd09641_cas3HD_CAS-I	gnl\|CDD\|193608
NC_022600.1\|WP_023173888.1\|2606517_2607588_+\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|236435
NC_022600.1\|WP_023173889.1\|2607616_2608597_+\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NC_022600.1\|WP_023173880.1\|2594257_2595247_+\|transcriptional-regulator	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
NC_022600.1\|WP_023173876.1\|2588932_2589850_+\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NC_022600.1\|WP_023173878.1\|2590715_2591927_+\|RNA-polymerase-sigma-factor-RpoD	unknown	unknown	gnl\|CDD\|236012
NC_022600.1\|WP_023173886.1\|2602698_2602932_+\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023173890.1\|2608605_2610357_-\|DUF1565-domain-containing-protein	unknown	unknown	gnl\|CDD\|284923
NC_022600.1\|WP_023173877.1\|2589855_2590410_+\|DUF2808-domain-containing-protein	unknown	unknown	gnl\|CDD\|371328
NC_022600.1\|WP_023173893.1\|2611818_2612775_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|274129
NC_022600.1\|WP_023173895.1\|2614953_2615553_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341392
NC_022600.1\|WP_144080304.1\|2598044_2599174_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|366234
NC_022600.1\|WP_023173881.1\|2595243_2595849_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NC_022600.1\|WP_023173882.1\|2595859_2596429_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NC_022600.1\|WP_023173894.1\|2612781_2614896_-\|IPT/TIG-domain-containing-protein	unknown	unknown	gnl\|CDD\|238050
NC_022600.1\|WP_023173879.1\|2591930_2594261_+\|O-antigen-ligase-family-protein	unknown	unknown	gnl\|CDD\|377422
NC_022600.1\|WP_023173883.1\|2596640_2597279_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NC_022600.1\|WP_023173887.1\|2603072_2606342_-\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
NC_022600.1\|WP_144080383.1\|2611481_2611814_+\|thiamine-biosynthesis-protein-ThiS	unknown	unknown	gnl\|CDD\|180978

Protein	Function_ID	Function_description	E-value
NC_022600.1\|WP_023173896.1\|2615569_2616721_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|376559	pfam01520, Amidase_3, N-acetylmuramoyl-L-alanine amidase. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls.	3.9674e-37
NC_022600.1\|WP_023173884.1\|2597275_2598025_+\|ATP-dependent-RNA-helicase	gnl\|CDD\|193608	cd09641, Cas3''_I, CRISPR/Cas system-associated protein Cas3''. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; HD-like nuclease, specifically digesting double-stranded oligonucleotides and preferably cleaving at G:C pairs; signature gene for Type I.	4.3974e-08
NC_022600.1\|WP_023173888.1\|2606517_2607588_+\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|236435	PRK09261, PRK09261, phospho-2-dehydro-3-deoxyheptonate aldolase; Validated.	0
NC_022600.1\|WP_023173889.1\|2607616_2608597_+\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	0
NC_022600.1\|WP_023173880.1\|2594257_2595247_+\|transcriptional-regulator	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	2.9368e-43
NC_022600.1\|WP_023173894.1\|2612781_2614896_-\|IPT/TIG-domain-containing-protein	gnl\|CDD\|238050	cd00102, IPT, Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.	0.000132525
NC_022600.1\|WP_023173878.1\|2590715_2591927_+\|RNA-polymerase-sigma-factor-RpoD	gnl\|CDD\|236012	PRK07406, PRK07406, RNA polymerase sigma factor RpoD; Validated.	0
NC_022600.1\|WP_023173876.1\|2588932_2589850_+\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	3.28322e-77
NC_022600.1\|WP_023173890.1\|2608605_2610357_-\|DUF1565-domain-containing-protein	gnl\|CDD\|284923	pfam07602, DUF1565, Protein of unknown function (DUF1565). These proteins share a region of homology in their N termini, and are found in several phylogenetically diverse bacteria and in the archaeon Methanosarcina acetivorans. Some of these proteins also contain characterized domains such as pfam00395 and pfam03422.	1.35737e-56
NC_022600.1\|WP_023173877.1\|2589855_2590410_+\|DUF2808-domain-containing-protein	gnl\|CDD\|371328	pfam10989, DUF2808, Protein of unknown function (DUF2808). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	6.64115e-39
NC_022600.1\|WP_023173893.1\|2611818_2612775_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|274129	TIGR02432, tRNAIle-lysidine_synthase, tRNA(Ile)-lysidine synthetase, N-terminal domain. The only examples in which the wobble position of a tRNA must discriminate between G and A of mRNA are AUA (Ile) vs. AUG (Met) and UGA (stop) vs. UGG (Trp). In all bacteria, the wobble position of the tRNA(Ile) recognizing AUA is lysidine, a lysine derivative of cytidine. This family describes a protein domain found, apparently, in all bacteria in a single copy. Eukaryotic sequences appear to be organellar. The domain archictecture of this protein family is variable; some, including characterized proteins of E. coli and B. subtilis known to be tRNA(Ile)-lysidine synthetase, include a conserved 50-residue domain that many other members lack. This protein belongs to the ATP-binding PP-loop family ( pfam01171). It appears in the literature and protein databases as TilS, YacA, and putative cell cycle protein MesJ (a misnomer). [Protein synthesis, tRNA and rRNA base modification].	2.77621e-71
NC_022600.1\|WP_023173895.1\|2614953_2615553_-\|hypothetical-protein	gnl\|CDD\|341392	cd04629, CBS_pair_bac, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	0.00462134
NC_022600.1\|WP_144080304.1\|2598044_2599174_-\|IS3-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	1.01308e-27
NC_022600.1\|WP_023173881.1\|2595243_2595849_+\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	2.23688e-40
NC_022600.1\|WP_023173882.1\|2595859_2596429_+\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	7.63016e-35
NC_022600.1\|WP_023173879.1\|2591930_2594261_+\|O-antigen-ligase-family-protein	gnl\|CDD\|377422	pfam04932, Wzy_C, O-Antigen ligase. This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.	7.49208e-17
NC_022600.1\|WP_023173883.1\|2596640_2597279_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	1.03991e-86
NC_022600.1\|WP_023173887.1\|2603072_2606342_-\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NC_022600.1\|WP_144080383.1\|2611481_2611814_+\|thiamine-biosynthesis-protein-ThiS	gnl\|CDD\|180978	PRK07440, PRK07440, thiamine biosynthesis protein ThiS.	1.79196e-29

>NC_022600.1|WP_144080304.1|2598044_2599174_-|IS3-family-transposase
MKKSRFTTEQIIAILGEGQAGANVAELCRRHGISEQTYYRWKAKYGGMEISEAQRLKDLEAENRKLKQIVADQALDLHALKAVLFKKILTPAAKRQAAAYLQADLQVSQRRACRLLGLHRSTARLVGHRTEDPVLLARLKQLAAERPRYGYRRLTLLLRREGRLVNAKKIYRLCTKEGLLVRPKKRKPRFRPSGRPEAPALERPNQLWSLDFVEDALADGRKLRTLTIIDVYSRECPQIEVDTSLPSARVVRVLETLAAQRQLPERLLVDNGPEFVCRALAEWATRRGVLIAFTRPGKPTDKPHIESFNGKFRDECLNAHYFLSVPDARRIVEAWRLDYNHYRPHSALAGATPMEFLQQVNAIAAPLSPQRHPPVR
>NC_022600.1|WP_023173884.1|2597275_2598025_+|ATP-dependent-RNA-helicase
MKRLLAKSFQKDKFPSPPDYALLLQHSRDVAQAGRTLARTVGAPLLAACGLPQELLPALETTLILCGWLQDLGKANSHFQTMVSSAPEVIQLLRHETVSGILAKLVPEFQDWLAPLGNETVHVAVWGAVGHHRKFDEETSPKQAPQAMTVLLSHPDFNSILQEMAQDLGLGQPPSFQKDLVISRSLKEKGDLGALEVCQELTTLFEDEEEAFASAARRQFVALVKALGTAADVAASAIDLAPNNDPLRM
>NC_022600.1|WP_023173883.1|2596640_2597279_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MTVVELDFGISGSSLPADHGYPLFSALSESVPEIHEADWLGIHTLPGVRDGHGSITLPSSSKLRLRLPMEKIPIVYPLAGKKICVGDYTLRLGIPQIRLLAPAQTLWSRLVVLKLADSKGQTAEPESFLAGVQRQLEALSIAGKPSLEKATQKPGLDAFARRVLRIKGVTITGYGIYVSGLSDEDSLKLQIAGIGGRRRMGCGLFVPVGGQS
>NC_022600.1|WP_023173882.1|2595859_2596429_+|Uma2-family-endonuclease
MSTGEIPQDLTPQQFLEWEEQQSERYEYFDGKIYHRTGITVAHNTVCLNLGCEINSYLRGKPGWVFMSAMKLQVTEDGPFFYPDVVVTCDERDEGRDILQYPCLVAEALWPNTEAFDRGDKFAQYRRIPTLQEYVLIDCGQQSVESFRRDNSSPNTWICHFYRPGSVVTFDSIGLRLPIDTIYEKVRFQ
>NC_022600.1|WP_023173881.1|2595243_2595849_+|Uma2-family-endonuclease
MSPLLESPAQTPIRFKLQPVLRLNDDQLFDLCQLNRDLRIERSAEGELLIMSPTGSEAGARNSSLTGQLWFWNRTLGLGRTFDSSAGFVLPDGAMRSPDAAWIRRERWDALSAEQRQKFAPLPPDFVAELRSPSDLIADLKAKMQAYIDNGVTLGWLIDPQTRQVWIYRPNLPPELLQSPLSLSDPLLPGFVLDLGDIFTE
>NC_022600.1|WP_023173880.1|2594257_2595247_+|transcriptional-regulator
MKKNPSPRHFERLLKLDGLIREGRPYTAAQLAEKLDVSVRTVQSDLDFLRDRYEAPLENSRTQGFFYRDPKWRLPLVPLSQGELFALVLGSRMLEAAAGAAYSQELQSAIDQLTKRMSDQTWADLQTIVDERFQFGAGGLLDLNPEFWKLLVEASSKQQQVEMMYYTASTNQLTTRKFDPYLMYVYRGTNPYTIGFCHNRQGIRVFRVDRIRQLRLCPEHFERETDFQPQRYLDTVFQIEAGGQPQPIAIHFSAKVAPFIRERRWHHTQQIEAHSDGSLTLRMSVPGLSEVKRWVLGYGEDAVVEGPLELVEMIRTAVARMAASYPPSP
>NC_022600.1|WP_023173879.1|2591930_2594261_+|O-antigen-ligase-family-protein
MSGKWLWAHLDLGLLAVAYALLLVLRNSYTEIAGWPWCLALQGCLLVGAIMALRSGRPLGQPFDALAGVSIAAVAVSAALSPDPERSWGYAAMVTGYFAVLYGLVGRWPRDRSLLPWLGAAGALFSLAGLYQFWQWIFLPQWQAGKPLNRLINNIYPLGHHNFNSGLLSLLLPVILALVFERRGPERGFWFVCLLIGLAMLFSTQSRGGWLGVLVGCVLVCLLSVRLSRRNGLLLAVALPVVLLVAVFSTTFASFKPKFFFEGRDISTEQRLIFWQTGVRLWQDHPLFGVGPGVTGFVFPGYRTDTDPWMARTAQQLHNTPVHLLAETGLAGLLAYMGWLAGCSWMLWRCLGQARPIVAALAGALAGYAVSSLTDFQLENPAISLTLIALVAELVRLAPPPAWQPPSWLRLIGGGVFLVWTAFWLRSDWGSYQAAIAFAHQNDPAAFEGAITQARRIDPDQPYYPLVQAQVLLDAARKLSPRDPRRAGWILQASEAADRAAALLPTDPYALTVAGWLHYYRGQWAWASRLFDQALAQDPTTTATLQLGAGLALLAQHRTEAALPHLVAEIVLFPDQWIDERWQTGPLGRLAPRVARNALALYNQLLSRYPGEHDALYQQAMLLLWLNQPLQALRKLDAMPVRQGVEPGNVPVALRLAWRVAPYQALGVRIQALWKLSRFEEAREALSSLDRLSPASAACLRDALIENQSVAKERFYLVNGQDYFLLRRIGGPVLQFPEPVHSETWASMDCVTFGYDGRNWRLPQAQKLISTPVLQR
>NC_022600.1|WP_023173878.1|2590715_2591927_+|RNA-polymerase-sigma-factor-RpoD
MTQANNVLDALQQPTIELEALALMAEEDDPYAGQAPDAADLADAAAASRPSRKRSRAQRTHYTEDSIRVYLQEIGRIRLLRADEEIELARQIADLLGLERLRARMSAPEMAGSVEVVELLTDEELLEENLLASSDVTESEQELRRWAEVADVPYEQFRERVAIGRRAKDKMVQSNLRLVVSIAKKYMNRGLSFQDLIQEGSLGLIRAAEKFDHEKGYKFSTYATWWIRQAITRAIADQSRTIRLPVHLYETISRIKKTTKLLSQELGRKPSEEEIATRMEMTIEKLRFIAKSAQLPISLETPIGKEEDSRLGDFIEADGETPEDKVAKNLLREDLEAVLNTLSPRERDVLRLRYGLDDGRMKTLEEIGQLFNVTRERIRQIEAKALRKLRHPNRNSVLKEYIR
>NC_022600.1|WP_023173877.1|2589855_2590410_+|DUF2808-domain-containing-protein
MKAFWICLSLLLSVAPATAIQLSDGESAFNGPLRLLRAAVTQNTVENFPVYYQFAIEAPAKLDEPLARIDIALPTEAGPYFGLYLPNPNQVRAFIPTDPYAQKPQEAARTLPIEATVNQSLISVRFLEPVAPGSVVTVEWGPVRNPSLDGNYLFSLTAFPPGPAPRGMYIGIGRIVIRSGGKDG
>NC_022600.1|WP_023173876.1|2588932_2589850_+|cation-transporter
MPFTATDTTAKKVQAVLWLTLVGNLLVLVIKAVLGFMSGSLSLLSDALHSLTDSGSNLVGLWAMANASPTPDREHPYGHQKFETIGALAIVAFLVFACIEILKNAVERIGSGTSPVAVTGWTLVGMIAVLAVNLATTLYERRQGEILNSEVLRADAEHTLSDVWVSVLVLVGLVGTWLGWRWLDMVLAFPVAAVVLFSAWRVLRRNLPLLVDERALDVQAIVDVACRVAGVVSCHDVASRGAPGRGLFIEMHMIVEPETIVEAHRITDAVEAALAEAFGPVRVTIHLEPAVVLNDPEHHRHLPEN
>NC_022600.1|WP_023173886.1|2602698_2602932_+|hypothetical-protein
MEGTATKKTVSDLEYDLLTVLKEKACAVTAYDTYIRDAQKVGSQPCVELFQKLQQQDNQCAEELRQHLTQVMQKGRM
>NC_022600.1|WP_023173887.1|2603072_2606342_-|carbamoyl-phosphate-synthase-large-subunit
MPRRTDIHKILLIGAGPIVIGQACEFDYSGTQACKALREEGYEIVLVNSNPATIMTDPATADRTYIEPVTAEIVARIIERERPDALLPTMGGQTALNVTVELAESGVLERYGVELIGAKLEAIKKAEDRELFKQAMGRLGLAVPRSGFAHSIEEAQAVAEEIGSFPLILRPSFTLGGTGGGIAYNREEFERMIKVGLDASPISQVLVEESALGWKEYELEVMRDLADNVVIICSIENFDPMGVHTGDSITVAPAQTLTDKEYQRLRDASIKVIREIGVETGGSNIQFAVHPEDGRVIVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDEITNEITRQTPASFEPTIDYVVTKIPRWAFEKFPGTEPVLTTAMRSVGEVMAIGRTFNESLQKALRSLEIKRSGFGADRIEENPDAETLKSQLRTATPDRIFQIRQALVAGFSVEQIHDLTAIDPWFLDKLAELVAFEQNWQHRDLLQVSAAELREAKHLGYSDAQLAFLTGTSEQAVRAIRQELGILPVFKTVDTCAAEFEAFTPYHYSSYAQENEIGPSDRPKVMILGGGPNRIGQGIEFDYCCCHACFALSEDGFETIMVNSNPETVSTDYDTSDRLYFEPLTREDVLNIFETEQPVGVIVQFGGQTPLNLAVPLEKAGVPIWGTSPDSIDMAEDRERFEQLCQALGVRQPANGMARSGSDATAVAGRIGYPVVVRPSYVLGGRAMEIVYTDDELAHYMTHAVQVEPDHPILIDKFLEDAIEVDVDAICDREGQVVIGGIMEHIEQAGIHSGDSACVLPTRTLSLEVLAVIRDWTARLARALKVVGLMNVQYAVKRTVTGEEEVYVLEANPRASRTVPFVAKATGVPLAKIAARVMAGRTLSELGFTAEVIPRHIAVKEAVLPFEKFGGTDTILGPEMRSTGEVMGIDTDFGRAFAKAQLGAGQRLPVRGTLFVSVTDRDKAAVVPIVREMIELGFRVIATEGTQRYLCSQGLAVEQVLKIHEGRPHIGDLLKNQQVQLVFNTPSGSEAQTDAQVIRRTALAQKIPVITTLAGARACAAAIASLQQGTLTVKSLQEYHAADASPTAARDPVG
>NC_022600.1|WP_023173888.1|2606517_2607588_+|3-deoxy-7-phosphoheptulonate-synthase
MNFHTDDLRIRWTEVVVSPARLHEELPLSETAAWTVYSSRKDLKEILDGNDDRLLVVVGPCSIHDPQAAREYAHRLKGLRETLAEDLLIVMRVYFEKPRTTVGWKGLLNDPHIDSSFRINEGLRLGRHLLLDLAELGVPAGTEFLDLMTPQYLSDLVSWGAIGARTTESQAHRELASGLSCPIGFKNGTSGNLQIAVDAVVSATHPHVFLGHSKEGQSAIFATVGNPDCHIILRGGRGTTNYSAEHVEQASGQLLKVGLPARVMIDCSHANSGKDYTRQPLVCRDIASQIAGGEKRIFGIMIESHLLAGRQDICPGEPLTHGQSITDACIGWEETELLLKELAQAVRARRARCLKS
>NC_022600.1|WP_023173889.1|2607616_2608597_+|quinolinate-synthase-NadA
MIATLPPRALIDPSLDLFEEIERLKHKLNAVILAHYYQEPDIQDVADYIGDSLGLSRQAAQTNADVIVFAGVHFMAETAKILSPQKQVLLPDLAAGCSLADNCPPDRFAEFIQAHPGHLVISYVNCSAAVKALSDIICTSANAASIVEQIPADQPIIFAPDRNLGRYVSQQTGRDMVLWQGTCIVHETFSERKLIGLKTRHPGAEVIAHPECEPQVLRHADFIGSTTALLNYAGKSTGEAFIVVTEAGILHQMQKAHPHKTFIPAPPQNNCACNECPFMRLNTLEKLYLCMRDRTPEITLDETIRQRALRPIERMLEMSPPVPGGG
>NC_022600.1|WP_023173890.1|2608605_2610357_-|DUF1565-domain-containing-protein
MKFSAKMVRSLTGWTLALSLLGPGASITRMVQAEPESSQELSAVHVDPINGNDSAGDGTKQNPFKTISRAAKAVPARGVLQLAEGEYSEASGEQFPLRLDGLELVGNESTKGEGIKIVGGGKHTSPTFASQDVTIVIGKGVTIRGVTISNPNNRGYGLWIESVSPVISDNSFIGSAHDGIFISGTSSAKINHNTFSQNIADGLTAADLSTPTIENNVFENTGFAINVTGKSRPRILGNIVRNNMDGVVIEGRAEPVLRNNTIANNKRSGVVVILLANADLGNESEAGNNTFADNGKADVNNVTKPAIPIVALGNKWLKPLLAGQVTAEAEIVALAAQNLPTQTDSFWVLVNESKPSRLSSIKGLALKPKSQSYQGKSYLQVGTFTTQDNADRLVQQLNEKGFKAIIVPAARPASKNVTTSAANKPVAPKAEPVAAIAATGAAKPVAKTAGPDTKVVAPPTTTRASEPVAKAAPKPEAPVPAKAPKAAEPAKSVLQSATSEPLAATTAKSATAYRVLVTGSSDADLPRLKELVSKVLPQTHDGKPAYQVGVFASEDNANHLVQLLSDKGFRAILVPSSLPGGAT
>NC_022600.1|WP_144080383.1|2611481_2611814_+|thiamine-biosynthesis-protein-ThiS
MRPTCSRSSPPGPIASPSCVRSWRQKIRPERRRIFWRNWTVEADKTIRLNGDERAVAAGTTVLAMLEQFKLEPRLLVIERNGDILHRQDWQKTIVQSGDRFEIVTVVGGG
>NC_022600.1|WP_023173893.1|2611818_2612775_+|tRNA-lysidine(34)-synthetase-TilS
MPADDEAAYRFRAALPLLPPGARLLVAVSGGQDSLCLLKLLFDAAPIQKWSLHVGHLDHRWRPDSERTAQQVGRLCWSWGIPFHLAIAKEVPHSEAAARAWRYSWLEQVALGLGLERVLTAHTLSDRAETLLFNLLRGSGGTGLASLDWQRPLGRLQLIRPLLDISRAQTAAFCEKHDLPVCIDASNFDLTYRRNRIRLELLPYLREHFNPQIEAALVQTAEVLRAESDCLEALAAPLYASLIDNQQLNRRQLALLPLALQRRVARHWLATVLQRAPNFDQTRAVLACLSAVNHTRTAPLAQGLLIEVRGEWLALVPS
>NC_022600.1|WP_023173894.1|2612781_2614896_-|IPT/TIG-domain-containing-protein
MGLLLGAVRLPAQAPIASFQAEALALQNTSLQALFSQIVRDARTRVLNTVATVTWPILPVEEDLSLRLRKLDAIRIPNQAFIQSNRDFSTDLIKSDTGAAQIYRWLNGTEELDPDSQDGYLKFLIENGMGTDLGEAAAVALDRQRVLEILKDYGGARLTIQVGSLQPTVLTNLVWEFTPYQGSLPGGKTYYRFGVRIVAENIGIVLDPKNGAEQTLKLTETLLADPNLPPVRLKDSTVTSRQKLRSEAIAEAAGAGQANPLLVLVNLLAPQLSERVATGPLNSERLSLITGLLVSSAGSRNLTGINVYLGDGSDPVANPGIAAGIAPSDASLYAGPSVSLGNNILVLSVGALFSGTQGEGTRFAGTASVDLSRLLFGKPDPAQSARQIDVAPQQIAGLYTSARLLAGTRLVVLKAGPALLAQLQPNPAAREVKINALSSAASVSTSIDSAGYIFFRSEQPTGTYSVRFCEPANPRNCLPAKPVELTDENRDQVLTLLPAAQTGGGTIPVVPTNPPRPSAPTLSIVSFTPAQGTPGAGFVTVATAGPALVRGTQVFFGGVPAPRVTIVRRTQLTADIPIGARSGPIEVRLPSGASTFSSTRFEVLATRPPIVPPPPVPVEGPQIVSIVPTHGVAGETSVTITVAGENLRRGTQVFFNGKAATGVNIVRRTELTADVPPDARSGPIEIILPSGRKLRSTVNFTVER
>NC_022600.1|WP_023173895.1|2614953_2615553_-|hypothetical-protein
MVLIRRLAFDGIPESGLSSACALGGFAPDGSTVLVASALGLVFREVQAGFERLRGAKVVLAGDPGGQLGTIDRIQTLLGPTVVAGAAVLIKLVEGSATGAILKLGDLAPVREALPVRLLSAGAGRTAIVARASSLFRPVSAALGGSDVLGFDIETTDGADFEEQDSGAPVVDENNALVGMLVYGSGPVAHCVTASSLFF
>NC_022600.1|WP_023173896.1|2615569_2616721_-|N-acetylmuramoyl-L-alanine-amidase
MNSLLRDLVNLYAALTIEFPQLKAVTLAQWLLESGRATSALAQDHYNFGGIKWREEMQPYATKVSYDASDGRGDYCDFGNLEDFIRGYWFFIDRPPYAGWRSHTATGQEFIEFIGPIYAPAPSTPSYAQKVLNLLSEAAGLLDDAPLGDDASDGPVVVSPPAGTAKSGVIVLDPGHGGTANVGGSSANNATSFSGILEKQMTLDLARRVQQALGDLAAAGGHDLKVFLTRSSDVNIGIQARARTAKAKNADLFLSLHFNAFNGQSSGTEAFIRSRPRNVNYDADLQFATRVQSAVLRSLRTHRPATRDRGVKVDTTSGPGGLGVLNDPDLGNTEGDARCRACLVETEFIDVKEVDDLLNRNPAAPAVRRDLALAIATALIDAL

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Crispr_ID: NC_022600_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022600_5

2971001-2971103

Orphan

Consensus_repeat	Method
ATCGACGACGAACTGGCCGCTCTCAAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022600_5

>merge|NC_022600|5|2971001-2971103|CRISPRCasFinder
ATCGACGACGAACTGGCCGCTCTCAAGCAAAAGCTCAAGGGCAGCACTGACATCAAAGATGCTGAATTTGAAGTGATCGACGACGAACTGGCCGCCCTCAAGC

>NC_022600|5|5|2971001-2971103|CRISPRCasFinder
ATCGACGACGAACTGGCCGCTCTCAAGC	AAAAGCTCAAGGGCAGCACTGACATCAAAGATGCTGAATTTGAAGTG
ATCGACGACGAACTGGCCGCCCTCAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022600.1\|WP_023174274.1\|2969900_2970338_-\|DUF2780-domain-containing-protein	unknown	unknown	gnl\|CDD\|378553
NC_022600.1\|WP_051382824.1\|2965866_2967141_+\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340817
NC_022600.1\|WP_023174277.1\|2971189_2972158_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|177093
NC_022600.1\|WP_023174286.1\|2981984_2982995_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381326
NC_022600.1\|WP_023174272.1\|2965080_2965653_+\|sugar-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100047
NC_022600.1\|WP_051382825.1\|2980093_2981797_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|274455
NC_022600.1\|WP_023174287.1\|2983084_2983750_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023174278.1\|2972254_2974507_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_022600.1\|WP_023174279.1\|2974585_2974852_+\|type-II-toxin-antitoxin-system-ParD-family-antitoxin	unknown	unknown	gnl\|CDD\|274227
NC_022600.1\|WP_023174275.1\|2970438_2970738_+\|DUF2470-domain-containing-protein	unknown	unknown	gnl\|CDD\|378456
NC_022600.1\|WP_023174283.1\|2979748_2980072_-\|metal-sensing-transcriptional-repressor	unknown	unknown	gnl\|CDD\|197393
NC_022600.1\|WP_023174271.1\|2964710_2965094_+\|SgcJ/EcaC-family-oxidoreductase	unknown	unknown	gnl\|CDD\|274053
NC_022600.1\|WP_023171280.1\|2967218_2968247_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_022600.1\|WP_023174268.1\|2963066_2963588_+\|DUF2231-domain-containing-protein	unknown	unknown	gnl\|CDD\|226695
NC_022600.1\|WP_023174273.1\|2968587_2969856_+\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NC_022600.1\|WP_023174282.1\|2978465_2979752_+\|homoserine-dehydrogenase	unknown	unknown	gnl\|CDD\|235783
NC_022600.1\|WP_041244777.1\|2963632_2964643_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235935
NC_022600.1\|WP_023174281.1\|2975214_2977962_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_022600.1\|WP_051382823.1\|2965649_2965889_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340817
NC_022600.1\|WP_023174280.1\|2974851_2975085_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|368240

Protein	Function_ID	Function_description	E-value
NC_022600.1\|WP_023174274.1\|2969900_2970338_-\|DUF2780-domain-containing-protein	gnl\|CDD\|378553	pfam11075, DUF2780, Protein of unknown function VcgC/VcgE (DUF2780). This is a bacterial family of uncharacterized proteins.	1.58349e-05
NC_022600.1\|WP_051382824.1\|2965866_2967141_+\|glycosyltransferase-family-1-protein	gnl\|CDD\|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	1.22728e-40
NC_022600.1\|WP_023174277.1\|2971189_2972158_+\|NAD(P)H-binding-protein	gnl\|CDD\|177093	CHL00194, ycf39, Ycf39; Provisional.	1.23537e-83
NC_022600.1\|WP_023174286.1\|2981984_2982995_+\|aldo/keto-reductase	gnl\|CDD\|381326	cd19100, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	1.43336e-102
NC_022600.1\|WP_023174272.1\|2965080_2965653_+\|sugar-O-acetyltransferase	gnl\|CDD\|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	8.77895e-99
NC_022600.1\|WP_051382825.1\|2980093_2981797_-\|GTPase-HflX	gnl\|CDD\|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	0
NC_022600.1\|WP_023174278.1\|2972254_2974507_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	5.45784e-62
NC_022600.1\|WP_023174279.1\|2974585_2974852_+\|type-II-toxin-antitoxin-system-ParD-family-antitoxin	gnl\|CDD\|274227	TIGR02606, Antitoxin_ParD, putative addiction module antidote protein, CC2985 family. This bacterial protein family has a very similar seed alignment to that of pfam03693 but is a more stringent model with higher cutoff scores. Proteins that score above the trusted cutoff to this model almost invariably are found adjacent to a ParE family protein (pfam05016), where ParE is the killing partner of an addiction module for plasmid stabilization. Members of this family, therefore, are putative addiction module antidote proteins. Some are encoded on plasmids or in prophage regions, but others appear chromosomal. A genome may contain several identical copies, such as the four in Magnetococcus sp. MC-1. This family is named for one member, CC2985 of Caulobacter crescentus CB15. [Cellular processes, Other, Mobile and extrachromosomal element functions, Plasmid functions].	3.29654e-16
NC_022600.1\|WP_023174275.1\|2970438_2970738_+\|DUF2470-domain-containing-protein	gnl\|CDD\|378456	pfam10615, DUF2470, Protein of unknown function (DUF2470). This family is a putative haem-iron utilisation family, as many members are annotated as being pyridoxamine 5'-phosphate oxidase-related, FMN-binding; however this could not be confirmed.	8.8062e-25
NC_022600.1\|WP_023174283.1\|2979748_2980072_-\|metal-sensing-transcriptional-repressor	gnl\|CDD\|197393	cd10158, CsoR-like_DUF156_1, Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156. Uncharacterized family 1, belonging to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes CsoRs (copper-sensitive operon repressors). CsoRs form homotetramers (dimer of dimers). In Mycobacterium tuberculosis CsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family; however, a conserved Tyr and a Glu residue that facilitates allosteric regulation of DNA binding for CsoRs are poorly conserved.	4.21427e-35
NC_022600.1\|WP_023174271.1\|2964710_2965094_+\|SgcJ/EcaC-family-oxidoreductase	gnl\|CDD\|274053	TIGR02246, hypothetical_protein, conserved hypothetical protein. This family consists of uncharacterized proteins found in a number of genera and species, including Streptomyces, Xanthomonas, Oceanobacillus iheyensis, Caulobacter crescentus CB15, and Xylella fastidiosa. The function is unknown.	1.0933e-21
NC_022600.1\|WP_023171280.1\|2967218_2968247_+\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	4.42886e-28
NC_022600.1\|WP_023174268.1\|2963066_2963588_+\|DUF2231-domain-containing-protein	gnl\|CDD\|226695	COG4244, COG4244, Predicted membrane protein [Function unknown].	2.93633e-33
NC_022600.1\|WP_023174273.1\|2968587_2969856_+\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NC_022600.1\|WP_023174282.1\|2978465_2979752_+\|homoserine-dehydrogenase	gnl\|CDD\|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	0
NC_022600.1\|WP_041244777.1\|2963632_2964643_+\|SDR-family-oxidoreductase	gnl\|CDD\|235935	PRK07109, PRK07109, short chain dehydrogenase; Provisional.	5.5436e-139
NC_022600.1\|WP_023174281.1\|2975214_2977962_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	5.85927e-41
NC_022600.1\|WP_051382823.1\|2965649_2965889_+\|glycosyltransferase	gnl\|CDD\|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	2.27472e-08
NC_022600.1\|WP_023174280.1\|2974851_2975085_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	3.56547e-09

>NC_022600.1|WP_023174275.1|2970438_2970738_+|DUF2470-domain-containing-protein
MAEVFTPEVSERICQHMNADHADAVALYARAFALEDSRPIEAARMLAIDPLGMDLLVTLRDAHLPVRIPFDPPLKDAEDAHHTLIDMVKTARARLAKTP
>NC_022600.1|WP_023174274.1|2969900_2970338_-|DUF2780-domain-containing-protein
MVSGTGNASSPGAQLIAQLAERLGIPHDLAAAAAGVALQFLSRQLEAGTFNEILDHIPLARTWLGQAVQGEQQAQATNPLAGLLGQVAGSLGGNLGSTAQLLAQLNQVGLSPETIGQFLPTFAGLLQQHLPPHLAEPAAQKLQTS
>NC_022600.1|WP_023174273.1|2968587_2969856_+|phosphopyruvate-hydratase
MSTVIEQVRAREILDSRGRPTLEAEVVLRGGATGWAAVPSGASTGSFEAHELRDGDKARYGGKGTLQAVSNILTVLAPEIVGLDALDQVGLDRRLIAIDGTPNKSRLGANALLGVSLATAHAASAALGLPLFRYLGGPLATVLPVPCFNVVNGGAHADNNVDIQEFMIVPVGAPSFREALRYGAEVFATLRGVLHDQKLGTGIGDEGGFAPDLKSNQEALDLLVQAIEKAGYRPGADIAIALDVAATELYKDGQYHFEQQALSAAEFIAALAKWVDSYPIVSIEDGLAEDDWEGWQQLTERLGGRVQLVGDDLFVTNRSRLQKGIDLGVANAILIKVNQIGTLTETLETIALAGRHRYRSMMSHRSGETEDVTIADLAVATRCGQIKTGSLARSERVAKYNQLLRIEEKLGDSAEYLGQRAF
>NC_022600.1|WP_023171280.1|2967218_2968247_+|IS110-family-transposase
MQRDGSQNDYQLFVGIDVAALTVTAAWLLTHAKPTAAITLPQTPEGHCQLAERLLAVCPTAAEVLVVIEATGSYWMRLATFLALKGFAVSVVNPAQSHYFARALLKRSKSDALDAQTLAQLAAALQPGLWQPPPEIYYQLQQRLQHRDALLQQRQQLHNQLHALRQFPLVVAAVQASLEQLSHTFDEQIAQMEAQLEALLAQDSLWHQAATKLRTIKGIGSVTAGWVLVSTLNFGCCATVEAAVAYAGLAPRSHRSGTSLHRPERIGHAGNARLRTALYMASLSAIRCNQQIKSFYQRLRAAGKPAKVALCAAARKLLHIAWAVVKTDTPFDAEHGRLVCLQ
>NC_022600.1|WP_051382824.1|2965866_2967141_+|glycosyltransferase-family-1-protein
MDLRGGTEYVVRSIFLPHLEQNYEQLLTVSQGADLIVSHTLAYAVPLVAEKLGLPWLSVYLQPAGIFSSYDPPALPAAPVLTAARGFGRWPYRAILALGKLASRSWIVPIEALRSRLGLPPSPRHPMVEPYSPYGSLAWFSRLLAVPQPDWPPRTTITGFPFYDKQTAEQAGLDPALEAFLARGEPPVVFTLGSAAVFDPGTFYEQSLIAVRRTGLRAVLLVGEEGMSALSKTTTERIYVGAYAPYSALMPRALLNVHQGGIGTTAQALRSGRPMLVVPFSHDQPDNAERVTKLGVARMIPRSAYTAQKAEAALQSLSTDQRFAQRAQSVAAQLRSEDGVTAACRAIESVCLTPPIPPAAAPARLPDCPRLSPLQPSYSEPPLVYCYWFQGSGEDCAPPCGFDRVEEIVPRYQGPAKLNRIEWH
>NC_022600.1|WP_051382823.1|2965649_2965889_+|glycosyltransferase
MKYRIVLVTYGSLGDLHSYLAVAIGLRERGHDVLLATSANYRLKVEGEGVAFHPLPPDIRSAGAGSGGTAAIDGSAGRH
>NC_022600.1|WP_023174272.1|2965080_2965653_+|sugar-O-acetyltransferase
MGATEREKMLAGELYRASDRQLVALRERARALFGLYNATGADETARRQALLGELFGKVGPTAEIEPPFFCDYGSQIEAGDRLYLNTGCVILDCCPVRLGENVLCGPNVHIYTATHPTDPRLRWEGYECALPVEIGDNVWLGGGAIVCPGVTIGSNAVIGAGSVVVKNIPANVVAVGNPCRVVRQLDSEPP
>NC_022600.1|WP_023174271.1|2964710_2965094_+|SgcJ/EcaC-family-oxidoreductase
MEAKAVQAIVERAATAWMTGDAAAFASLFTADGECIVPGNRWVGQKAIAAALAEFAAGHTNVKISVRQIVADGDHAVVEWSWEDTETATGKRTVADDAIAVDFVRGQIRRWREYIDAQTPSRANGSN
>NC_022600.1|WP_041244777.1|2963632_2964643_+|SDR-family-oxidoreductase
MRLKPLAQQVVVVFGASSGIGRETALRLAQKDAKLVVAARTESALVSLVETIRAQGGQAVYQLADAARIDEVQAVAERAIVEYGRLDTWVQVAGTAVIGPFLETTAAEFERVVQVNLLGQVYGAMAALPHLKRQGGALIHISSVEARRSMPLQSAYAASKHGIEGFLDSLRLELEHDRLLVSVTNILPGVINTPFYNKALTKLGVKPSSVPPFYQPGLVADAILFAAEHPVRELIVGDAGRVLDYLQRLSPALTDRLLQLVGFKFQYTDQIEGESAPNNLFEPIEGDNRTEGDYRQLTIPSFFDWLDRYPGAKWALGGAAVAAVALLAAGQSRRGE
>NC_022600.1|WP_023174268.1|2963066_2963588_+|DUF2231-domain-containing-protein
MGRHPNIPPIVESRESDYRDSGVESSVAIAGHPLHPAIVTFPIAFLVAAFGSDLGYYLTRDPFWARASLWLLGAGLITGLIAALTGMSDFLRVKRVQARTAGWLHMSLNVVALGLTVVNFWARLGDSAAAVLPFGIVASAIVAALLGASGWFGGELSFRHKIGVIGDHDERVP
>NC_022600.1|WP_023174277.1|2971189_2972158_+|NAD(P)H-binding-protein
MKILVVGATGNLGRQIVRRAIDEGHTVRCLVRNREKAQFLEQWGAQLFGGDLREPESFGPLLAEVEAVILAASALANRDARDKTNNIENVDDRGMRAFIDAMQGLPIERVVYTSLLRADEFAGIKMMAIKRAVEAHLERSGLPYTILRLAPFMQGLIPEYALPILEKKPVRVPRTPSPIAYLSTLDAAAFAVAACTAGGAKNATVEVSGPELWQTDAIIKLCDDLANHKQVPKVSLLSDGQKRLNAFLARMLNPNLIDLLQFSEAFATGKPYAADMEAAGAIFDIPATALTRVDPFLREYFAIIKRRLREKNYQEPKIKLPF
>NC_022600.1|WP_023174278.1|2972254_2974507_+|TonB-dependent-receptor
MRWVAVVFLLLAIEGEAVLAEPGLVLTRRALAKQEADIQTVAQALEPGNPTSPAGGISLDEVVVTANRRPTAIKETTSTVYVVDRKEIERKDAVNVGEAIRGVPGVQANVFGAGADVHNNFFVRGLPNLGVGVLVDGRLITSINQEHFDLADLPVYNVERIEVLTGSGTTLYGSNAAGGIINVITRKPTGPLEGDIKVEFGSYGFSNYILNYGGKLDKFGFHLGYRQFDASNDYYYQVQRPTGLFTGFRPNGDVHQKFYDLNLSYDFDDRNRLRFDGYLRGGDRGLAPFSIIDPSRPLVNDEGEPQFELTRLNTQSHGLALTYDADLGQGNDSHLQVTAAIDRNLVVERETFDPTDLGEYTDVSIFNFSIRHDWQFNPSNNLTYGFDYIREFGRSGENAAGGLFNFDTGASRPALFALYTWKVASNLIMTVGARETIPDNLQAKGLNRALTSSFDPSAGIRWQITPTLALRANYARIYRIPNFNDLFGRTTHIGNPFLEPETGNSYDVGLDWQTGNTSLLRLTYFRQEVDNLTDYLLVRNACNLNGNAPDCNDDPASNAERFRVNYPRIDVSGWELAYNWQISPVLNVFATGTVTDSRIIQAPNPATIDAQLQQLGIINNSDEGTFRVDVAERNALVQTQYPLVPFLTTRFGLNYESPTGFAASLFVNLSGGRSVDVNHVGPFDTTHPARLPPGSLLPGYTTLDLSLRVPIARTIVLNAFIDNLLGTYYERSYGNAAPGFNFRVGLSTSF
>NC_022600.1|WP_023174279.1|2974585_2974852_+|type-II-toxin-antitoxin-system-ParD-family-antitoxin
MPTSVALGEHFEAFIKAQLASGRYNNASEVVRAGLRLLEEQEKLEELRRAELRAAVQEGIDSGPGRSVEAVIAELRARRSAQRDQRQV
>NC_022600.1|WP_023174280.1|2974851_2975085_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MQVVLSKRAELDLEEITSFIALDDPAAAERFEDKLLEHTRAIGLAPLAYRARPDLGANIRSCAHGRYLIFSPLIQAR
>NC_022600.1|WP_023174281.1|2975214_2977962_-|TonB-dependent-receptor
MSKNIQLMSCPGSVLAVAVLLAGSLSLVGAGRALAEPVVPDGYRLARSSEEATPHLRDLLREASGTGAADLQNIPSAWQWTQPLEPKLSQKRPADLPEPPAATAAGPDEDQSNFLDEVSVTATRRPTRARDSTQSVNIVKREDFQAQGAVTVSDALLLIPGFNNSTPALGGQSNLSANFLRGFPDTEYVVLRDGVRLGSPFNGRSDVSAIVLDDLERIEVITGGSTLRYGSGSVGGVINLITETPKGRPRLTVSYEYGSYSFNRTVAKFSGGDDIFAYNLIFTGIAAQNNYPFGFTLPRTPQFYGPNDVARNPGCNSDNAADFDAFGTCLNGGFPDGTSLYGYLKPEVGPPLKVQGINNESHVGNDNYMAKLIYKPTTNNKLSFRFNQHNLLIDDRSPGYFDYNACGIIAGPTATKNGTYNFDRFLPVDISGREQRCPLQTYLPVTASSTLALPYSYSNSYNGRISFKPGFSYPSAEQAQGEDAFFRQRSSSESEFTFSWDWDINSSQSLNTYFLYYRQALHFYRDPLYFYNSDLLGGIAANGSTASGAGELLIGANLLRPYVVGQRYEVQSSYNVQLSPGQILSAGVNYVQDKLDYQENVRGDNNELLSYFNKGFSTSRLSVFVVDDIIFSKLLTTNVGLRYTNSDQFGSILTPAAGVRVNLSDNLSLRGNYSQVFNSASLLNLYVTTGTYGQNTGLPNPSLKPETGITYDIGVDWSPARNLAFKLTYFDTYVDNKFNNQTFFNPNFAPGNGEPVTISQTINLGSYRGSGIEFSGDWQFADQWRLRVVWTNVDARPYGNYSDDIDSVTYPNYKEFQDYNLPFNSVIAALTYTNKGLSATLLGRYDDGKYRFRGDNSSRVPSWLTLDLNLEIPITTAFTMTASVFNITDTQYEYLDANPAPGTTFRLGGRFTLGG
>NC_022600.1|WP_023174282.1|2978465_2979752_+|homoserine-dehydrogenase
MAGTLRLALIGLGTVGSSVLAILNDVAGLDLRLGAVQVVAAAVRDLTKARNGPLPPLYEDALALACRPDIDVVVEVMGGVELPYQLLKAALKAGKHVITANKALLARHGEELFALARTQNRQLRYEAAVGGGIPLLQPIEQCLGANHIQAVTAIINGTTNYILTQMATRQIAYEEALAEAQSLGYAEADPRADVEGNDAQEKLTLLAALAFRTPLPDLAAVYREGITAVALPDVMNAQQLGFAIKLLAIATRTADGRLDLRVHPTLVPLDHPLSRVDGAYNAVLIQAEPVGSIMFYGPGAGGGPTASAVVSDIINILADAPTGAIPPASEAAPLHYLPITAVQTRFYIRLRALDQPGVIGHIGQIFGQHAVSLASIVQKNPRGAAAELVIITHDVPEARLRAALAELRASAVVQEFCTAIRVLPEGKR
>NC_022600.1|WP_023174283.1|2979748_2980072_-|metal-sensing-transcriptional-repressor
MSSELQPTALPIESAVHHHHDPAHIKVLVDRLARIEGHVRGISNMVREDRPCPEVLVQISAVRAALTQVARLILKEHLSDCIVHAVNNGGGLAEIQALNQAIDRFLD
>NC_022600.1|WP_051382825.1|2980093_2981797_-|GTPase-HflX
MDKIYGSHKGLKPAQLRQLSRLYSLPFPLNRFLSIEFGERLAALSAELETPLCVYANRRGQVVRVGVGTPKETQFSIDELPRQGTERLSGLRCIATQFDMQGPNRGALTALALQRLDALVILDVAVEGFRRRSAAPSGFVQRAQIANLVPDPLARWVVSTPQSLSQVAAQDFDVFLEDLEDEFRRTATARAVESDRERVLLVDFFSTRTSQRAMEEELSELVQLVTSAGGEVLKVFYQRRAQPDPSTLIGQGKLEEVALSVQDLGANLVVCGRELTPTQGRNLEQAVGVRVVDRNELILDIFARRARSHEGKLQVELAQLQYLLPRLTGRGGALSRLGGGIGTRGPGETKLETDRRIIRRRIAKLQLEVNALQAHRARLRARRQRKEVPVFALVGYTNAGKSTLLNTLTDADALVADQLFATLDPTTRRLELPTGDPVLLTDTVGFIHDLPPQLIDAFRATLEEVTEADALLHVVDLSNPAWMNHIQAVQRILESLPIATGPQLLVFNKVDRVSPELRSFAEQEYPLALFISAQKGWGFLSLRQALLRWVRSLTDLPLAESSIDGEP
>NC_022600.1|WP_023174286.1|2981984_2982995_+|aldo/keto-reductase
MGSSRRQFLITTSGTLAAGIAAGTGSTVQAAGQTKSGEMLYRTLGRTGEKVSAIGLGGHHIGRPKDEQEGVRIVRAAIDRGITFMDNCWDYHEGGSELRMGKALQGGYRQKVFLMTKIDGRTREAAARQIDESLRRLQTDRIDLLQHHEVLRLEDPDRIFAAGGAMEAVLAAQKAGKVRYIGFTGHKDPLVHLRMLEVAAQNNFRFDTVQMPLNVMDAHFRSFEAQVLPKLVADQIGVLGMKSMGDSHVLKSNTVRPIECLHYALNLPTSVVITGIDSMQLLDQAFEAARTFEPLNPDQVSALLARTREAALRGRFELYKTTPQFDTTAQKPQYLG
>NC_022600.1|WP_023174287.1|2983084_2983750_-|hypothetical-protein
MPTFVVRLLLGLVWIAFGIYAFFLAPAETQTPQQLVQSLTALALGQGEPLVVSLFNLMGLIPLLYLFLLIPDGHGQKLPAWPFGLAAFAVGAFALLPYLILRQPHHNWPTRKPAGWLVRIFDSRWLVLLTAVGIGWFFYNGLTHGDWAAFAAQWHASRFVHVMSLDFVVSTALLPVLIPDDLYRRNSKQIWPLWLAAAVPLVGPIAYLLWRPSLFPREGLD

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Crispr_ID: NC_022600_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022600_6

2987556-2987629

Orphan

Consensus_repeat	Method
CCCCCACCTGGCCCCAAAAGGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022600_6

>merge|NC_022600|6|2987556-2987629|CRISPRCasFinder
CCCCCACCTGGCCCCAAAAGGGGCCTGCCCCCCGCTCTCCTCCTCCTGCCCCCCGACCTGGCCCCAAAAGGGGC

>NC_022600|6|6|2987556-2987629|CRISPRCasFinder
CCCCCACCTGGCCCCAAAAGGGGC	CTGCCCCCCGCTCTCCTCCTCCTGCC
CCCCGACCTGGCCCCAAAAGGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022600.1\|WP_023174301.1\|2996882_2997764_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|215031
NC_022600.1\|WP_023174296.1\|2991377_2991899_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NC_022600.1\|WP_023174299.1\|2993467_2995894_-\|sucrose-synthase	unknown	unknown	gnl\|CDD\|274149
NC_022600.1\|WP_023174300.1\|2995994_2996876_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NC_022600.1\|WP_023174287.1\|2983084_2983750_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023174282.1\|2978465_2979752_+\|homoserine-dehydrogenase	unknown	unknown	gnl\|CDD\|235783
NC_022600.1\|WP_023174297.1\|2991921_2992974_+\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225807
NC_022600.1\|WP_023174281.1\|2975214_2977962_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NC_022600.1\|WP_041243954.1\|2992974_2993430_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_051382825.1\|2980093_2981797_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|274455
NC_022600.1\|WP_144080396.1\|2984064_2984355_+\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023174294.1\|2991102_2991381_+\|DUF1778-domain-containing-protein	unknown	unknown	gnl\|CDD\|370057
NC_022600.1\|WP_023174289.1\|2984430_2986233_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NC_022600.1\|WP_023174293.1\|2989438_2990917_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NC_022600.1\|WP_023174291.1\|2987182_2987320_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023174292.1\|2989235_2989430_+\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023174286.1\|2981984_2982995_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381326
NC_022600.1\|WP_023174283.1\|2979748_2980072_-\|metal-sensing-transcriptional-repressor	unknown	unknown	gnl\|CDD\|197393
NC_022600.1\|WP_023171280.1\|2987713_2988742_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376564
NC_022600.1\|WP_023174290.1\|2986235_2987156_-\|HPr-kinase	unknown	unknown	gnl\|CDD\|275150

Protein	Function_ID	Function_description	E-value
NC_022600.1\|WP_023174301.1\|2996882_2997764_-\|AAA-family-ATPase	gnl\|CDD\|215031	PLN00020, PLN00020, ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional.	1.25544e-127
NC_022600.1\|WP_023174296.1\|2991377_2991899_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	0.00611996
NC_022600.1\|WP_023174281.1\|2975214_2977962_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	5.85927e-41
NC_022600.1\|WP_023174299.1\|2993467_2995894_-\|sucrose-synthase	gnl\|CDD\|274149	TIGR02470, Sucrose_synthase_1, sucrose synthase. This model represents sucrose synthase, an enzyme that, despite its name, generally uses rather produces sucrose. Sucrose plus UDP (or ADP) becomes D-fructose plus UDP-glucose (or ADP-glucose), which is then available for cell wall (or starch) biosynthesis. The enzyme is homologous to sucrose phosphate synthase, which catalyzes the penultimate step in sucrose synthesis. Sucrose synthase is found, so far, exclusively in plants and cyanobacteria. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NC_022600.1\|WP_023174300.1\|2995994_2996876_+\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	4.9183e-46
NC_022600.1\|WP_023174289.1\|2984430_2986233_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	8.3893e-108
NC_022600.1\|WP_023174282.1\|2978465_2979752_+\|homoserine-dehydrogenase	gnl\|CDD\|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	0
NC_022600.1\|WP_023174297.1\|2991921_2992974_+\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	2.46006e-74
NC_022600.1\|WP_023174293.1\|2989438_2990917_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NC_022600.1\|WP_051382825.1\|2980093_2981797_-\|GTPase-HflX	gnl\|CDD\|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	0
NC_022600.1\|WP_023174294.1\|2991102_2991381_+\|DUF1778-domain-containing-protein	gnl\|CDD\|370057	pfam08681, DUF1778, Protein of unknown function (DUF1778). This is a family of uncharacterized proteins. The structure of one of the hypothetical proteins in this family has been solved and it forms a helix structure which may form interactions with DNA.	1.20579e-20
NC_022600.1\|WP_023174286.1\|2981984_2982995_+\|aldo/keto-reductase	gnl\|CDD\|381326	cd19100, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	1.43336e-102
NC_022600.1\|WP_023174283.1\|2979748_2980072_-\|metal-sensing-transcriptional-repressor	gnl\|CDD\|197393	cd10158, CsoR-like_DUF156_1, Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156. Uncharacterized family 1, belonging to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes CsoRs (copper-sensitive operon repressors). CsoRs form homotetramers (dimer of dimers). In Mycobacterium tuberculosis CsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family; however, a conserved Tyr and a Glu residue that facilitates allosteric regulation of DNA binding for CsoRs are poorly conserved.	4.21427e-35
NC_022600.1\|WP_023171280.1\|2987713_2988742_-\|IS110-family-transposase	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	4.42886e-28
NC_022600.1\|WP_023174290.1\|2986235_2987156_-\|HPr-kinase	gnl\|CDD\|275150	TIGR04355, HPr_serine_kinase_domain-containing_protein, HprK-related kinase B. Members of this protein family resemble (and often are misannotated as) HprK, the serine kinase/phosphatase of the phosphocarrier protein HPr. However, members do not occur with an HPr homolog, but instead as part of a distinctive gene cassette of unknown function.	2.71652e-06

>NC_022600.1|WP_023174291.1|2987182_2987320_-|hypothetical-protein
MKSSQKRAYIAPQVKPLGNLTAMTAAYPPLHPECYPGGFGSHSVC
>NC_022600.1|WP_023174290.1|2986235_2987156_-|HPr-kinase
MAMLKANRASSVLDTLAEIAYRELQPALKAEQVCLRSVDALPVALDGRGLSEEIFAGERGGRRWLAWSETVGVWIDEDGQRVEILLVNPEAGQCESSLLNFMTASVLGTCLLLQGRVAVHANAVAFKEGAMAFVGHAGRGKSTLSAYCLSQGAALVSDDVLSVDRQMQAIPGYARLKLFAHTAESLGLVAGTTDYKLHLHPTRLGGQVQNQPVPLKAIYLLEQSDGDRIESRTVPPAQAVFELIAHSYYARYFAVTHPGLLAAYAELVARVPVEQLFYPRQFARLPDVFAFLRTRTWQRSAPGVHS
>NC_022600.1|WP_023174289.1|2984430_2986233_-|ABC-transporter-ATP-binding-protein
MAQQNRLQIRQVLQLGRALRLVWQSSPGWTSANLVLLVVQAVLPVASLYLTKLLVDGVSSGLLLPDKSSALATVLPLLGLLGLTALAAAACRALSGWVSEAQTQVVTDYLHGIVHRKAAAVDFAYYENARYYDTLHRALQEAPFRPARIIAGLVQLGQSVFSLLAVALLLLTLHWGTALLLLAAVLPGTLVRLRYAETLFRWQRLRTPRERRAWYFNGMLTGDSHAKEIRLFDLAEAFEQRYCELRAELRRERLQLASKQALADFATQAGAAVAILACLGYIALRTLQGGLTLGDLFMYFQAFQRAQTYLQEALGSLVRLYEDNLFLSYLYEFLDLPNHVAEPAEPVSLPLPLQSGIRFENVSFCYPDSKESALDHIDLTIAPGQIVAFVGENGSGKTTLVKLLCRLYDPSAGRITVDGIDLRDLSLRTWRQTVSAIFQDFARYHLSAAENIAPAHAEESEPIARAAQASGAHEVIAQLRDGYQTLLGRWFDQGEELSVGQWQKVALARAFWRDCPVLILDEPTSAIDAAAEDEIFEKFQLLAARRTTVLISHRLSTVKLADRIYVLAQGRIVEQGSHDELIARQGTYARLFELQAQHYR
>NC_022600.1|WP_144080396.1|2984064_2984355_+|hypothetical-protein
MLFIKIDTGVFLFLFDIEPVMVGDYSLQVINGEPNFERTFLTAPQIKRTACDLVAQVASGQQIELPVLLGEWEPNAEINGNWQQDLNANRLPQVAG
>NC_022600.1|WP_023174287.1|2983084_2983750_-|hypothetical-protein
MPTFVVRLLLGLVWIAFGIYAFFLAPAETQTPQQLVQSLTALALGQGEPLVVSLFNLMGLIPLLYLFLLIPDGHGQKLPAWPFGLAAFAVGAFALLPYLILRQPHHNWPTRKPAGWLVRIFDSRWLVLLTAVGIGWFFYNGLTHGDWAAFAAQWHASRFVHVMSLDFVVSTALLPVLIPDDLYRRNSKQIWPLWLAAAVPLVGPIAYLLWRPSLFPREGLD
>NC_022600.1|WP_023174286.1|2981984_2982995_+|aldo/keto-reductase
MGSSRRQFLITTSGTLAAGIAAGTGSTVQAAGQTKSGEMLYRTLGRTGEKVSAIGLGGHHIGRPKDEQEGVRIVRAAIDRGITFMDNCWDYHEGGSELRMGKALQGGYRQKVFLMTKIDGRTREAAARQIDESLRRLQTDRIDLLQHHEVLRLEDPDRIFAAGGAMEAVLAAQKAGKVRYIGFTGHKDPLVHLRMLEVAAQNNFRFDTVQMPLNVMDAHFRSFEAQVLPKLVADQIGVLGMKSMGDSHVLKSNTVRPIECLHYALNLPTSVVITGIDSMQLLDQAFEAARTFEPLNPDQVSALLARTREAALRGRFELYKTTPQFDTTAQKPQYLG
>NC_022600.1|WP_051382825.1|2980093_2981797_-|GTPase-HflX
MDKIYGSHKGLKPAQLRQLSRLYSLPFPLNRFLSIEFGERLAALSAELETPLCVYANRRGQVVRVGVGTPKETQFSIDELPRQGTERLSGLRCIATQFDMQGPNRGALTALALQRLDALVILDVAVEGFRRRSAAPSGFVQRAQIANLVPDPLARWVVSTPQSLSQVAAQDFDVFLEDLEDEFRRTATARAVESDRERVLLVDFFSTRTSQRAMEEELSELVQLVTSAGGEVLKVFYQRRAQPDPSTLIGQGKLEEVALSVQDLGANLVVCGRELTPTQGRNLEQAVGVRVVDRNELILDIFARRARSHEGKLQVELAQLQYLLPRLTGRGGALSRLGGGIGTRGPGETKLETDRRIIRRRIAKLQLEVNALQAHRARLRARRQRKEVPVFALVGYTNAGKSTLLNTLTDADALVADQLFATLDPTTRRLELPTGDPVLLTDTVGFIHDLPPQLIDAFRATLEEVTEADALLHVVDLSNPAWMNHIQAVQRILESLPIATGPQLLVFNKVDRVSPELRSFAEQEYPLALFISAQKGWGFLSLRQALLRWVRSLTDLPLAESSIDGEP
>NC_022600.1|WP_023174283.1|2979748_2980072_-|metal-sensing-transcriptional-repressor
MSSELQPTALPIESAVHHHHDPAHIKVLVDRLARIEGHVRGISNMVREDRPCPEVLVQISAVRAALTQVARLILKEHLSDCIVHAVNNGGGLAEIQALNQAIDRFLD
>NC_022600.1|WP_023174282.1|2978465_2979752_+|homoserine-dehydrogenase
MAGTLRLALIGLGTVGSSVLAILNDVAGLDLRLGAVQVVAAAVRDLTKARNGPLPPLYEDALALACRPDIDVVVEVMGGVELPYQLLKAALKAGKHVITANKALLARHGEELFALARTQNRQLRYEAAVGGGIPLLQPIEQCLGANHIQAVTAIINGTTNYILTQMATRQIAYEEALAEAQSLGYAEADPRADVEGNDAQEKLTLLAALAFRTPLPDLAAVYREGITAVALPDVMNAQQLGFAIKLLAIATRTADGRLDLRVHPTLVPLDHPLSRVDGAYNAVLIQAEPVGSIMFYGPGAGGGPTASAVVSDIINILADAPTGAIPPASEAAPLHYLPITAVQTRFYIRLRALDQPGVIGHIGQIFGQHAVSLASIVQKNPRGAAAELVIITHDVPEARLRAALAELRASAVVQEFCTAIRVLPEGKR
>NC_022600.1|WP_023174281.1|2975214_2977962_-|TonB-dependent-receptor
MSKNIQLMSCPGSVLAVAVLLAGSLSLVGAGRALAEPVVPDGYRLARSSEEATPHLRDLLREASGTGAADLQNIPSAWQWTQPLEPKLSQKRPADLPEPPAATAAGPDEDQSNFLDEVSVTATRRPTRARDSTQSVNIVKREDFQAQGAVTVSDALLLIPGFNNSTPALGGQSNLSANFLRGFPDTEYVVLRDGVRLGSPFNGRSDVSAIVLDDLERIEVITGGSTLRYGSGSVGGVINLITETPKGRPRLTVSYEYGSYSFNRTVAKFSGGDDIFAYNLIFTGIAAQNNYPFGFTLPRTPQFYGPNDVARNPGCNSDNAADFDAFGTCLNGGFPDGTSLYGYLKPEVGPPLKVQGINNESHVGNDNYMAKLIYKPTTNNKLSFRFNQHNLLIDDRSPGYFDYNACGIIAGPTATKNGTYNFDRFLPVDISGREQRCPLQTYLPVTASSTLALPYSYSNSYNGRISFKPGFSYPSAEQAQGEDAFFRQRSSSESEFTFSWDWDINSSQSLNTYFLYYRQALHFYRDPLYFYNSDLLGGIAANGSTASGAGELLIGANLLRPYVVGQRYEVQSSYNVQLSPGQILSAGVNYVQDKLDYQENVRGDNNELLSYFNKGFSTSRLSVFVVDDIIFSKLLTTNVGLRYTNSDQFGSILTPAAGVRVNLSDNLSLRGNYSQVFNSASLLNLYVTTGTYGQNTGLPNPSLKPETGITYDIGVDWSPARNLAFKLTYFDTYVDNKFNNQTFFNPNFAPGNGEPVTISQTINLGSYRGSGIEFSGDWQFADQWRLRVVWTNVDARPYGNYSDDIDSVTYPNYKEFQDYNLPFNSVIAALTYTNKGLSATLLGRYDDGKYRFRGDNSSRVPSWLTLDLNLEIPITTAFTMTASVFNITDTQYEYLDANPAPGTTFRLGGRFTLGG
>NC_022600.1|WP_023171280.1|2987713_2988742_-|IS110-family-transposase
MQRDGSQNDYQLFVGIDVAALTVTAAWLLTHAKPTAAITLPQTPEGHCQLAERLLAVCPTAAEVLVVIEATGSYWMRLATFLALKGFAVSVVNPAQSHYFARALLKRSKSDALDAQTLAQLAAALQPGLWQPPPEIYYQLQQRLQHRDALLQQRQQLHNQLHALRQFPLVVAAVQASLEQLSHTFDEQIAQMEAQLEALLAQDSLWHQAATKLRTIKGIGSVTAGWVLVSTLNFGCCATVEAAVAYAGLAPRSHRSGTSLHRPERIGHAGNARLRTALYMASLSAIRCNQQIKSFYQRLRAAGKPAKVALCAAARKLLHIAWAVVKTDTPFDAEHGRLVCLQ
>NC_022600.1|WP_023174292.1|2989235_2989430_+|hypothetical-protein
MSQQTYKNIEGYRNFWLAATPVIDGAVRTIGLHRTLPPLYKTAKVIGVLNIAIPTLILAVIEEV
>NC_022600.1|WP_023174293.1|2989438_2990917_-|sugar-ABC-transporter-ATP-binding-protein
MALLQIENVTRRFGPVTVLDGVDFEVEAGEMHALVGENGAGKSTLMKILCGALAADSGTIRWQGAPVRLDSPRAARAQGIAMIHQELALVPELSVAENICLGEAQSWWRPVDFAQIEVTARRLLERLGQAIDPCALVRQLSLPQQQMVETARALRQRTRLLILDEPTASLSAQQTAQLFAVLRRIRDDGTAIIYISHRLEEIFELCDRVTVLRNGKRVHSASVGSLTPGAVVQHMVGRTLEASTPHQRPVAQRPVLAVRHLRTGPLKDVHLELRAGEIVGLMGVAGSGRSRLVRTLFGAQAAEGGTIHLGERPVKLRSPAEAIALGIGLLGEDRKRHGLIPERVVRENMALGTLKNHSRMGMIAQDRERRACGELAGQLRLAPCCQEMAIRTLSGGNQQKALLGRWLLAGCRVLLLDEPTRGVDVEAKAEIYSLIRTLAAGGTAILLVSSDLPELVQVAERLLVLQGGRIVSEQSPPYDVKHILSLALGVRS
>NC_022600.1|WP_023174294.1|2991102_2991381_+|DUF1778-domain-containing-protein
MSRAAINDNGRMSFRVRPEQKAILMRAAAIKKTGLTDFVLQNALQAAERVIEAAERVQLSERDSLRVLDLLENPPAPNAKLRAAAAALPPLR
>NC_022600.1|WP_023174296.1|2991377_2991899_+|GNAT-family-N-acetyltransferase
MTPAWHEEAIARHHDRKAFDCGDQDLNNFLRHSARQSHDRGGAKTFLAIGDSDGSILGFYSVAPAELAYARTPEVVRRGLAKHAVPGFRLARLAVHVDVQKKGLGGQLLLAAGRRCLRTAAEVGGVVLLIDAKSPPAASWYAGFGAVALEDAPLTLMLPLETIEISLRAAEKL
>NC_022600.1|WP_023174297.1|2991921_2992974_+|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein
MTTRQNFLLYGANGYTGGLIARKATEGGLRPVLAGRSQAVARLGAELGLEYRIFNLEDRAALDRALEEVVAVLHCAGPFVRTSGLMVAACLRTGTHYLDITGEVAVFEAAMARHEQAQRAGVMLMPGVGCDVVPTDCLAAYLAAQLPEADSLVLALQILNVVSRGTALTIVEGPYEGGLVRRDGILTPVPAGYKTRSFDFGAGAEEATTIPWGDLNTAFWQTGIPNIEAYLVLPPAARFLLFAGQWLGGVLRSEPVRNLQKQFIASGPPGPTEAERRAGVCRFWGEVTKEGRSVQARLRTVEGYTLTALTALLIAQKVLSGQFQPGFRTPAQVYGADLILEVEGSLREDL
>NC_022600.1|WP_041243954.1|2992974_2993430_-|hypothetical-protein
MSLLPWPEIAWSVVLSDLGLLVVCPLLTLLFISNPLTRNPILLGVVLPLLCGVVAGVAVRLCFDKLFKEQILDNGVGWALVLGVALTVYPMGLALGTALEAVPNLFNLPAPAAEFSRNLGKLLQISRILFDLVFVVGGAMGMFWRAIRIGR
>NC_022600.1|WP_023174299.1|2993467_2995894_-|sucrose-synthase
MSELLQMVIDSDERADLRQFIGLLYQQEKRYLLRSDILQIFSEYCASVGKEANFYNHSLLARLIYFTQEFIVENESLCLVIRPVVARQEVVRINREDLRVEPMTIQAYLDLCDQTAGRFRPQDGDVLELDFQPFYDFSPSIRDPKNIGRGVQFLNRYLSSKLFQDPGQWLQTLFQFLRLHRYNGTQLLINERIQTQQQLSTQLKRVLALVSSRRPDEPYANFRFDMQSLGFEPGWGNTAARVRESLELLDALIDSPDHEILESLISRIPMLFRVVLVSSHGWFGQEGVLGRPDTGGQVVYVLDQARSLEKQLQEDHALAGLETTPKVIILTRLIANNDGTRSNQRLEKVYGTDNAWILRVPFREFNPSVTQNWISRFEIWPYLESFALDSERELLAELGGRPDLIVGNYSDGNLVAFLLARRLKVTQCNIAHALEKSKYALSNLHWQELDEQYHFSLQYTADLIAMNAANFIISSTYQEIAGTPDSMGQYESYRHFTMPELYHVVSGIDLFNPKFNVVPPGVNENIYFPYTRTEERTPGDRERLEQLLFSLEDSEQVFGHLADPTKRPLFSMARLDRIKNLTGLAECFAKSPELQERANLILVAGKLRAEDSTDREEIAEINRLYEIVDRYQLAGKIRWLGVRLAKVDSGEIYRVVADRQGIFVQPALFEAFGLTILESMISGLPTFATRFGGPLEIIQDGVNGFLINPNAQEEMAASIVEFLSKCDANPDYWQQISSRGIQRVYSTYTWKIHTTRLLSLARIYGFWNYGSQENREDLLRYIEMLFYLLYKPGAQKLLERHALQVAIE
>NC_022600.1|WP_023174300.1|2995994_2996876_+|metallophosphoesterase
MLSRRRLLVSGLIATGGATLALPAWARVEADSLKFETVPIPIVGLEAPLRVAQLSDIHWDHRSVPWNSIEQAIDYINAAEVDLVALTGDFVTYDPAPIFELAPALGRLRARHGLFAVLGNHDNAHPRGARTIKKALAREQIVLIENRWTAVASLAVGGTGDLWHGPFEPERVLMPLRGRRPLLLLSHNPDGFWRLGEQRLDLQLSGHTHGGQVRLPGVGPVLALKNRLGDRLRRYLPELGDSLQKHAIIRTNSWAGLYGQGKNCLYVSRGMGRFKRLSIGCPPEVTIIDLIPA
>NC_022600.1|WP_023174301.1|2996882_2997764_-|AAA-family-ATPase
MTDYFLPERFRDKVALHIARNFAQLPRVQVPLLLGVHGPKGQGKSFMVERSLEDLGANTIHIASAELESPDAGEPSRLIRLRYREAAELVRVRGRVAVLVIHDIDAGAGYWRDSIQYTVNTQMVNAALMAIADNPTNVQLPGSYDAKPLPRIPIVVTGNDFSKLYAPLTREGRMDKFYWEPTPAELSGILQGMFADDPQMSRFDLERLQERFARQPVDFFAAIRARAYDEQLLRQIKAWGLENISLHLVNHGGQPPVFERLRLTLDHCLRWGDQLLAEQQALHTGLVEAYMHQ

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Crispr_ID: NC_022600_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022600_7

4271404-4272947

TypeIII

Consensus_repeat	Method
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CRISPRCasFinder
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CRT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	PILER-CR

19 spacers

csx1,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cas2,cas1,csx18

The CRISPR arrays of NC_022600_7

>merge|NC_022600|7|4271404-4272947|CRISPRCasFinder,CRT,PILER-CR
GCTTCCAATCTAATCGTTCGCTGAGGGACGTCGAACCTCCTGCACAGTGATCGGTATGTTGGATCTAGAGTGCCAGGTACTCACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACACGCCCGGTAACACGCCCGGTAGCCCATCGGTAATCATTCAAAATCTCTACGTCACCACGTTTCCAATCTAATCGTCCGCTGAGAGACGTCGAACACTTCCTGGCCCTCGGAGACGCCCAGGCGCAGACCGGTTAACCCGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACACCCGCCACTCTCACGTGGACTGCCCTCGGCTCCCGAAAGTTTTTATGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTCGCATTTACATTACTGCTTGCGTAGTGGGTGGCATCACCTTTGGTGTGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAGATTGTTCGCGCCGATATCGATCGTGCCAACAGCACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTGGCTCTGCTTACGACCAGCGTGATGAAGACCAGAAAGCAGTTGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACATCCGTGCCGATTTGTTATTGTTGTCCGTATTCGACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAAGTTCGATTAAATGACTCAATAGTATACCGAATAGCTCCGGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACGATGGGGGCGGAGGGGCGTTTTGGTTCCCCGGCTTTTCCGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTTCATGTCTTCTAACAGCACTGCGGGAGAAGGAGTCTAATTGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTTTCACTAGGTCTGGAGTTCAAATGGACATCGTCATCGTATTCCTCACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAGAGTAGCGAGCAGGAAAACGCCTCAGATACTTAGATGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCGGCGGCGTCATTTGGAAGAAGAGGGTGACTTAATGGACAAGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACGAGCGCTATTACCAATGGCGGGTTAAAAACAATCTGCATGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACACAGTGGCCTTACTGAGTGGAGGGGAAAGCTCCCGCCGATCGCGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCATTCGTTTATAAGTATTGGGTGATCTTCAACTAGTGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACATGAGTTGGTGGCGGCACGGAAACGGAAATAGTCAGATCCTCATCCCTGACTAGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTCAAGTATCTTCATTACGACCGCATGGACCAGCTCACCAAGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACA

>NC_022600|7|7|4271404-4272947|CRISPRCasFinder
GCTTCCAATCTAATCGTTCGCTGAGGGACGTCGAAC	CTCCTGCACAGTGATCGGTATGTTGGATCTAGAGTGCCAGGTACTCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACGCCCGGTAACACGCCCGGTAGCCCATCGGTAATCATTCAAAATCTCTACGTCACCAC
GTTTCCAATCTAATCGTCCGCTGAGAGACGTCGAAC	ACTTCCTGGCCCTCGGAGACGCCCAGGCGCAGACCGGTTAACCC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACCCGCCACTCTCACGTGGACTGCCCTCGGCTCCCGAAAGTTTTTAT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TCGCATTTACATTACTGCTTGCGTAGTGGGTGGCATCACCTTTGGTGT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGATTGTTCGCGCCGATATCGATCGTGCCAACAGCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TGGCTCTGCTTACGACCAGCGTGATGAAGACCAGAAAGCAGTT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ATCCGTGCCGATTTGTTATTGTTGTCCGTATTCGAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AAGTTCGATTAAATGACTCAATAGTATACCGAATAGCTCCGG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GATGGGGGCGGAGGGGCGTTTTGGTTCCCCGGCTTTTCC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTCATGTCTTCTAACAGCACTGCGGGAGAAGGAGTCTAATT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTTCACTAGGTCTGGAGTTCAAATGGACATCGTCATCGTATTCCTCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGAGTAGCGAGCAGGAAAACGCCTCAGATACTTAGAT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CGGCGGCGTCATTTGGAAGAAGAGGGTGACTTAATGGACAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GAGCGCTATTACCAATGGCGGGTTAAAAACAATCTGCAT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACAGTGGCCTTACTGAGTGGAGGGGAAAGCTCCCGCCGATCGC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CATTCGTTTATAAGTATTGGGTGATCTTCAACTAGTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ATGAGTTGGTGGCGGCACGGAAACGGAAATAGTCAGATCCTCATCCCTGACTAG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TCAAGTATCTTCATTACGACCGCATGGACCAGCTCACCAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACA

>NC_022600|7|4|4271404-4272946|CRT
GCTTCCAATCTAATCGTTCGCTGAGGGACGTCGAAC	CTCCTGCACAGTGATCGGTATGTTGGATCTAGAGTGCCAGGTACTCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACGCCCGGTAACACGCCCGGTAGCCCATCGGTAATCATTCAAAATCTCTACGTCACCAC
GTTTCCAATCTAATCGTCCGCTGAGAGACGTCGAAC	ACTTCCTGGCCCTCGGAGACGCCCAGGCGCAGACCGGTTAACCC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACCCGCCACTCTCACGTGGACTGCCCTCGGCTCCCGAAAGTTTTTAT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TCGCATTTACATTACTGCTTGCGTAGTGGGTGGCATCACCTTTGGTGT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGATTGTTCGCGCCGATATCGATCGTGCCAACAGCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TGGCTCTGCTTACGACCAGCGTGATGAAGACCAGAAAGCAGTT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ATCCGTGCCGATTTGTTATTGTTGTCCGTATTCGAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AAGTTCGATTAAATGACTCAATAGTATACCGAATAGCTCCGG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GATGGGGGCGGAGGGGCGTTTTGGTTCCCCGGCTTTTCC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTCATGTCTTCTAACAGCACTGCGGGAGAAGGAGTCTAATT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTTCACTAGGTCTGGAGTTCAAATGGACATCGTCATCGTATTCCTCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGAGTAGCGAGCAGGAAAACGCCTCAGATACTTAGAT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CGGCGGCGTCATTTGGAAGAAGAGGGTGACTTAATGGACAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GAGCGCTATTACCAATGGCGGGTTAAAAACAATCTGCAT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACAGTGGCCTTACTGAGTGGAGGGGAAAGCTCCCGCCGATCGC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CATTCGTTTATAAGTATTGGGTGATCTTCAACTAGTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ATGAGTTGGTGGCGGCACGGAAACGGAAATAGTCAGATCCTCATCCCTGACTAG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TCAAGTATCTTCATTACGACCGCATGGACCAGCTCACCAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC

>NC_022600|7|6|4271406-4272870|PILER-CR
TTCCAATCTAATCGTTCGCTGAGGGACGTCGAACCT	CCTGCACAGTGATCGGTATGTTGGATCTAGAGTGCCAGGTACTCACGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAC	GCCCGGTAACACGCCCGGTAGCCCATCGGTAATCATTCAAAATCTCTACGTCACCACGT
TTCCAATCTAATCGTCCGCTGAGAGACGTCGAACAC	TTCCTGGCCCTCGGAGACGCCCAGGCGCAGACCGGTTAACCCGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAC	CCGCCACTCTCACGTGGACTGCCCTCGGCTCCCGAAAGTTTTTATGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTC	GCATTTACATTACTGCTTGCGTAGTGGGTGGCATCACCTTTGGTGTGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAG	ATTGTTCGCGCCGATATCGATCGTGCCAACAGCACGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTG	GCTCTGCTTACGACCAGCGTGATGAAGACCAGAAAGCAGTTGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAT	CCGTGCCGATTTGTTATTGTTGTCCGTATTCGACGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAA	GTTCGATTAAATGACTCAATAGTATACCGAATAGCTCCGGGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACGA	TGGGGGCGGAGGGGCGTTTTGGTTCCCCGGCTTTTCCGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTT	CATGTCTTCTAACAGCACTGCGGGAGAAGGAGTCTAATTGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTT	TCACTAGGTCTGGAGTTCAAATGGACATCGTCATCGTATTCCTCACGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAG	AGTAGCGAGCAGGAAAACGCCTCAGATACTTAGATGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCG	GCGGCGTCATTTGGAAGAAGAGGGTGACTTAATGGACAAGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACGA	GCGCTATTACCAATGGCGGGTTAAAAACAATCTGCATGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAC	AGTGGCCTTACTGAGTGGAGGGGAAAGCTCCCGCCGATCGCGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCA	TTCGTTTATAAGTATTGGGTGATCTTCAACTAGTGGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAT	GAGTTGGTGGCGGCACGGAAACGGAAATAGTCAGATCCTCATCCCTGACTAGGT
TTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022600.1\|WP_023175636.1\|4259682_4260672_-\|DUF1517-domain-containing-protein	unknown	unknown	gnl\|CDD\|369378
NC_022600.1\|WP_081705323.1\|4278471_4279017_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NC_022600.1\|WP_041244093.1\|4279514_4279910_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023175645.1\|4275126_4275402_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_022600.1\|WP_023175641.1\|4266809_4267607_+\|hypothetical-protein	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NC_022600.1\|WP_023175647.1\|4276391_4276616_-\|hypothetical-protein	csx18	cls000006_csx18_CAS-I:CAS-III	gnl\|CDD\|371663
NC_022600.1\|WP_023175652.1\|4280003_4280726_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NC_022600.1\|WP_023175651.1\|4279083_4279518_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NC_022600.1\|WP_023175648.1\|4276636_4277896_-\|hypothetical-protein	csx1	mkCas0109_csx1_CAS-III	gnl\|CDD\|312974
NC_022600.1\|WP_023175638.1\|4262187_4264029_+\|HipA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377920
NC_022600.1\|WP_023175653.1\|4280764_4281823_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_022600.1\|WP_023175643.1\|4268016_4269678_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377130
NC_022600.1\|WP_023175642.1\|4267610_4268024_+\|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	unknown
NC_022600.1\|WP_041244091.1\|4264341_4265835_+\|hypothetical-protein	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
NC_022600.1\|WP_023175649.1\|4278082_4278358_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|368240
NC_022600.1\|WP_023175635.1\|4259202_4259529_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023175644.1\|4269684_4271235_+\|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	unknown
NC_022600.1\|WP_023175646.1\|4275403_4276399_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|376633
NC_022600.1\|WP_023175640.1\|4265819_4266806_+\|hypothetical-protein	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NC_022600.1\|WP_041244090.1\|4260837_4262052_+\|acetylornithine-transaminase	unknown	unknown	gnl\|CDD\|235056

Protein	Function_ID	Function_description	E-value
NC_022600.1\|WP_023175636.1\|4259682_4260672_-\|DUF1517-domain-containing-protein	gnl\|CDD\|369378	pfam07466, DUF1517, Protein of unknown function (DUF1517). This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.	1.88456e-79
NC_022600.1\|WP_081705323.1\|4278471_4279017_+\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	3.15272e-09
NC_022600.1\|WP_023175645.1\|4275126_4275402_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.61705e-29
NC_022600.1\|WP_023175641.1\|4266809_4267607_+\|hypothetical-protein	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	4.92348e-23
NC_022600.1\|WP_023175647.1\|4276391_4276616_-\|hypothetical-protein	gnl\|CDD\|371663	pfam11674, DUF3270, Protein of unknown function (DUF3270). This family of proteins with unknown function appears to be restricted to Streptococcus.	0.00978937
NC_022600.1\|WP_023175652.1\|4280003_4280726_-\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	1.85145e-19
NC_022600.1\|WP_023175651.1\|4279083_4279518_-\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	3.75999e-10
NC_022600.1\|WP_023175648.1\|4276636_4277896_-\|hypothetical-protein	gnl\|CDD\|312974	pfam09659, Cas_Csm6, CRISPR-associated protein (Cas_Csm6). Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	3.62155e-09
NC_022600.1\|WP_023175638.1\|4262187_4264029_+\|HipA-domain-containing-protein	gnl\|CDD\|377920	pfam07804, HipA_C, HipA-like C-terminal domain. The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.	7.04056e-47
NC_022600.1\|WP_023175653.1\|4280764_4281823_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_022600.1\|WP_023175643.1\|4268016_4269678_+\|hypothetical-protein	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	1.91418e-05
NC_022600.1\|WP_041244090.1\|4260837_4262052_+\|acetylornithine-transaminase	gnl\|CDD\|235056	PRK02627, PRK02627, acetylornithine aminotransferase; Provisional.	0
NC_022600.1\|WP_041244091.1\|4264341_4265835_+\|hypothetical-protein	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	2.48955e-12
NC_022600.1\|WP_023175649.1\|4278082_4278358_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	8.99625e-09
NC_022600.1\|WP_023175640.1\|4265819_4266806_+\|hypothetical-protein	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	5.87688e-07
NC_022600.1\|WP_023175646.1\|4275403_4276399_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	9.76132e-105

>NC_022600.1|WP_023175644.1|4269684_4271235_+|hypothetical-protein
MSLWIVTVGSSDVQLSSRSNWYTLFEKVRSELECEEFSPQEVESEAAERRYVVPGRVLGLVYGTSSKHEDLVFPLLDAYTSRLLPLQPPSKVVFLLTDQSNLALERRLPQSPYWQDTCTLAPLLAAYIHRRLNLEPQMLILTPPKGGRGIDHWDATLKLVGEQLMQLTTKLHEPVYVSHQAGTPALSSAVQFMSLSQFGEQVRFLVVNRFDSGEPVECIESSRYLRGIRAQEARRLVVDGIPGAALNLLTVSDSEATFRHPELVKLVNFFNLRSTGTGREKDFDLDQVAQRLFEALELISIFFHQRNYLTGITLLAAAHELFLKAAVIRALTTRSEIVIRGNSLLLNQLIEWNEYGLRLKKSELLIRFGLPDDKDGKNWGGLKEGIDKCLNYPKPALNRRFFDANANLLPWLKALRADFVSWPLLNWICDDKRSTEQDLRNQLMHNLRGIEEEDVVRYLLAGKQAEIGESPASTYRVKILEPFLAALELVGSVDKDAVLLDHRLNETAKHLVHYSL
>NC_022600.1|WP_023175643.1|4268016_4269678_+|hypothetical-protein
MDSNKVPQLFRAQVEGRCQLQNPRTDDAQRWAYEWIAKADRRAPAFSRTVRQRRYRITWRFVTNGGQDDGVIRPVLGARGWPYYPGSSMKGAFRSACRQAAPDKVIRYCGGSDGQGGWRPGILRFHGGYPANADWQQRERLVDLVHPQEGVQVEASSSRHSAFALFSLYRPELRFALSSNKPLEDVEWTEIWSIWEKALSHGIGSRVSAGYGRVVREQDGERELLVADPLVSVHLTGQGQASYLLTKASPRPAEFRPNMFKAALRGHTRRLFGGFVDEATAEELTYELWGGIQGKAKAGLLGVVFNGEAELGTHGRGSFAVPTYTVKDGWLRVVQTRDIPDERCHELIKLVARLMQFSLLLGGFGKSWRRVDHRLFYPQYYTDSNKPLIGCHWKLSEKKLHPVYVTINDLQDVGKAIEKIRNQCHRWIMSHPNIKLREKPCHWREAWHADKVQVWGRVASDKADSRAVSWFHGPYQNQATIKGSELTGRLGAIGRIWHRMYPRVIREADHLVAKPEFVELLTLFPDSSQQTQRFINFLATPQSGFTKLWPFEE
>NC_022600.1|WP_023175642.1|4267610_4268024_+|hypothetical-protein
MSWQSYQLDRAAQELVLRHRDKGVLNQSYKMRQAAAFGLERFWGEHVRLMKEDATAAGYWKQTWDSLVTILKKAGLELPNHTIKDPKKTQDIQAMADELWKLSPQKQRVALAVLVQFCDCLIWWTQRYKTGKEKSDG
>NC_022600.1|WP_023175641.1|4266809_4267607_+|hypothetical-protein
MYSRAYGVIEALAPLHVGASAGEESGNLNLIFRDQFTQTGIVPGSSIRGRLRAEMRQAGEQDEQEWYGRGTDAGRTDGMSESAVKFEYASLIWLPVFCPGQPIVWVSCPRLLARYQRIAGMQGELPRPYTGSKDLQGIDGKDVLFFNLGFLTLKRKEDLSAWFPERRARPAVVVEDSDMAVIHDMALYRQSRVKLHDEVKVVDGGAFFNVEALPEETLLVFPVAIKPTTNGKTWQPFSDGMSAEIYLGGLESIGFGHCRVTIYGV
>NC_022600.1|WP_023175640.1|4265819_4266806_+|hypothetical-protein
MFQYVITVEPLGLLYGSAGAFLSPANLVGRAGRRFPPDAPTLSGLYYNGASEALRRELGEKLHLAGPFWAEQEDPLNFYVPIPWTRVVGEDSSDEWTIADHHWQRTDPDLKPAYRWQPINSWKAPLRNLQKNQARKDPWQFVPALHPHLKDDERCVPEQDGLFLENAAQMCPGTCLVYLASHPLSAGWYRFGGESHVVQIGCRDLPERSKAMALLAEPIDRAFALLTPGIWGSNRFSLRHPQHPDFPKPVLMLTEKPVPFRYRIAEQLGRGRYAVPAGSVYVLSQPLDQPWRDWNSDWFPREGHSYKRWGCGLALPLEIEGLQTLQGV
>NC_022600.1|WP_041244091.1|4264341_4265835_+|hypothetical-protein
MSALYTVFTFAPVQGFIEKSRKLRDLYGASIILSYLTFRLTEKAEAAEGVQVISPGMPNVQEGMPNRIVLSGVVTVEEYQKAFFENWRRMLREVRDWIERQLPAYEYCWRDEWQHWGNHAWEFFWGQGASVPEAVNDLEARKLARSWTGINWTGESSSLSGTDAIAWPGLGRVVDVRSRKLNQEKQQIQLFYSELAKRLDPQGEGKFLAENEQLSIPELTKRLVTRHDLARSLGMTELEAGFTDLAREQDKGTWTGWLMGDGDKIGNYLKDLARSEDGGALRHFSEAMREWGRSFARDFAQEKLGRVIYAGGDDFLAVFYRPQKKLLPGEVIDWLCNFPKIWRQHGQKVTVSAGFVWAAPRVPQRDVLQHCREAEQLSKAAGRDRLTLRVVFNSGQYVQWTCPWEYLKTLMERRNQVDWTRLYKDLAELQARHAFEENHESADPRVALALFDIYFPRQGEYLNAHRTLVHKDKFSGQAINSWISDLIRVGWHLCSNT
>NC_022600.1|WP_023175638.1|4262187_4264029_+|HipA-domain-containing-protein
MALYLIGLNLDSPTAHYRAERGYLVQLLRGIYVDATDDVDAVVLQHAVRIAKYLYPNTYLSAASAILLGPTADGRLFLSGRRKQRTRIRTLEIIQNQAPAYPSVAPTLVKDSLGEISVDVSAIRQSLLEAFRRRSEQSASIDPAMKQALVERLVSEYGSPSKAADAVWALARENQWYREGEEAEQWLLRQPPIVVSNAETGITFHITWHGVPLGRLRNDGFEWRWLLEKVDLISPVRDTVPGQLPPFISSLLPEGWTEEVLQTDDEREVLLGGRRYLSNIAIVDDLAKLASLPVDVLDGRLARWMQEGRFVGAYAGPGRGHIAKGFEWAVAELYRDRDTPRLSGVQIKAPMYLNALGQLLDARGRPFTHILKPAGAAGFEATPIVEWTALELAKRMEFVVPAHALVEMPEQLPPALVVERFDIRCGLEDNQQLYCQEDFCSLLNISSAKKYGSTIEQVAKTLRSVSTEPEADLLLLWRRALFAWLIADGDMHLKNLAVLRIAVPGERSFLSVRLAPVYDTLTTRVFPGMAQDRMALKLNGKNDRLQASDFLTLARTIGIKVSTAEQALAQMTSKLASAVRDICLPALAYYGPQGLEKFTQLQQIVETRCKKMA
>NC_022600.1|WP_041244090.1|4260837_4262052_+|acetylornithine-transaminase
MKTVETVRQAFEEHVMHTYARFPVVFERGEGCYLEDSEGRRYLDFVAGIATCALGHAHPVLGAAIAEQARTLIHVSNLYYTRQQGELARWLTDNSVADQVFFCNSGAEANEGAIKLARKYGRTVLGIAEPQIISTHLSFHGRTLATVTATGQPKYQKHFHPLVPGFVHVPYNDFDALRAQVTDATCAVLIEPIQGEGGVMPGDVDFFRKLRRFCSEQRILLILDEVQTGMGRTGKLWGYEHLGIEPDIFTLAKALGGGVPIGALCAKAEFSLFEPGDHASTFGGNPLACAAGLAVCQTLEAEALVENARVRGEQLAAGLKRIAERFGSLVRLSRGRGLMQGLVLVAPRAAEVVRLAMDEGLLLVSAGPEVVRLVPPLIVSAIEIDEALAILEGVLARLPVTVTA
>NC_022600.1|WP_023175636.1|4259682_4260672_-|DUF1517-domain-containing-protein
MARITSLMRGVLAGGLALGLLLSGTGSFQSSDVAWARGSSGGRIGGGSFRSAPRSYAPAPRYAPGGGYGGGYYSPGPVVPVPVPIPFGGGYGYGYGYGGGFGLSSIFVIVIVVGAGLFFLRFIRRNAAGVGDYGGYDGEPIDSGKIDVFRLQVALLATAKQLQRDLIRLAEQSDTSTPEGLTRLNQEVTLALLRNPEYWVYAKSDAQELPRLQAESQFNRLALAERTKYTDEVVSKTGSTGLVQKKFDGENPDEVAEYIVVTLLVATEDGAPRLLNVRSSDDLRQALTILGSLSSEQIVAVEVVWSPADENDTLTSDELLTQYTDLVRL
>NC_022600.1|WP_023175635.1|4259202_4259529_-|hypothetical-protein
MPTNNPKISAYVPQYVFDRFKQYEKEQGLSMSQAVADILIRYFELTPARRPAAPPAIPAEVVERIASLERKVELLEKIAIPAPASLNSPLTFTSEAAGPDDADPAPSK
>NC_022600.1|WP_023175645.1|4275126_4275402_-|CRISPR-associated-endonuclease-Cas2
MLWVVAYDIPVTKRRNKIAKLLEGYGKRVQYSVFECDLEESQFSELRNRLLKLLKLPDDSLRYYPIAANMTRKIVILGGDGLYEKPDHFAV
>NC_022600.1|WP_023175646.1|4275403_4276399_-|CRISPR-associated-endonuclease-Cas1
MSSLYLLEQGIWVGKDGEQLAIHRKREVVRQIPLPLIDRIFVFGRIHLSIEVLRTCLRRRIPLALLSRQGWLYGTLSPPQQGRLHLRRAQQRVQEESERSLRLAQSLVEAKIHNQRVLLQRLNRRRPIAENEFAVDVLRYLESRVPQTSNIAALLGNEGAAAAQFYPAYGRQLQDSEFRLVERIRRPPTNPANAVLSFGYSLLWNHVRAVVELHGCDPYLGHLHVPRDDHLALISDLIEPFRTPIIDSLVLTMVNRRMFTSEDFEYANGACFLADSGRRKFVTQFQQIMGETIQLPNGRDGVRWKLIDQGVENYKTALQNPELPFNVYRIR
>NC_022600.1|WP_023175647.1|4276391_4276616_-|hypothetical-protein
MNSARLLFFRNVAVASVNTAVTLVILLIAPLGLAAVLTCTVAVGLSSLIIGLCADQVARWLFSDGGLAVRAPRE
>NC_022600.1|WP_023175648.1|4276636_4277896_-|hypothetical-protein
MVSVVVSFVGKQDPSSERPGYPTNQEGSLVTLTRYLQGQGLTVGGVVLLYTADQVERMELCREWLVQDLYLEAATVMALPVNEVLSTDPIDIQAAITEARRGIELASMALCAADRIELNASSGTPAMKSAWNLLQAAGYVPNARVWQVRDPTQMSVAQARVFESDTSYLRDEFDAKVLARQIADFNYAGALDSLAQSHLETPQLTGLLRFGRFRLAFDFNRAHAALADVDSPLRNELMREITPLRQRRPPVLLRELYFNALVRFATCEYSDFLGRVFRFQEAVMQLVVEERCGLTLLNRNHWQVIDQIDGGKLRKYLDGYRLPGGGRLQLNSDFNRRILEAILEYFNQDILLLHLRVINSYGDLRNRCIVAHGYEGLSEIRGSEHLTQTMGKILLEIGIISGKHPFEVLNSHILRILRM
>NC_022600.1|WP_023175649.1|4278082_4278358_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MEVRWTDKSLVDLNRLHAFLRPTNPQAAARVVRSLIAAAKRLEQFPQLGTALPEFAPRNVRRLIVADYEMRYELKDDALFILRVWRAREDR
>NC_022600.1|WP_081705323.1|4278471_4279017_+|Uma2-family-endonuclease
MAALFLFDKIRQRLPDIPPVVPDGFLSLEVERVFDEDLRLSYVLWEELKVPTLVLKVVSKTRNKEYRQKKALYAELGVPYYVIYAPRRRRKEHLEIYRLVEEPYVLLPGQPAWIEELGLGIGRERGTYEGVTREWLYWYDRDGKRYATPEERLAQAEEQVERNRERIRALEQKLRESGIEP
>NC_022600.1|WP_023175651.1|4279083_4279518_-|HNH-endonuclease
MSSGYISEELRERVRQHAQDRCGYCLSPQKYVLGRLEIEHIIPLAYGGTNEEENLWLSCRLCNSYKGTQVRARDPITGRSTKLFNPRTQRWSRHFRWSPDGTRVIGYTVCGRATVIALQMNNLIAVTVRQQWELAGWHPPVDLP
>NC_022600.1|WP_041244093.1|4279514_4279910_-|hypothetical-protein
MTTRITLDVPDEIYRRAQDLAQVSGREVREVLSEALALSLAPVSPAPESGDFTAAEKLSDEQVLALCELQLPEQQDQHLSELLNRQQAGMLGEFERLELAGLMQIYQFQLLRKAQALREAVQRRLLPPLSP
>NC_022600.1|WP_023175652.1|4280003_4280726_-|Uma2-family-endonuclease
MYQPNPAADVIWPPTDLWSDEPPMESDWHRKQMQVLIESLESHWRDRQNFYCSGNLTIYYSLTQRKSEDFRGPDFFVVLGCERRERRSWTVWEEGGRLPNVIVEILSESTAEIDRGLKKQIYQDVLRVPEYFWFDPQSQELCGFHLVEGQYEPLEVSESGRLWSGQLELFFGVPEDRLRLLTADGTVIPTPMERALEAEQQVLQEQQRAVQAEQQVVQERQRAERLAQRLRELGLDPDAL
>NC_022600.1|WP_023175653.1|4280764_4281823_-|tRNA-2-thiouridine(34)-synthase-MnmA
MTAGIKLAAALSGGVDSSVAAALVRQQGYRVLGITLWLMRGKGSCCSDGMKDAARVCEQLGIAHHIVDVREQFEETIVDFLVTGYQQGVTPLPCSRCNKELKFGLLLDYARHKLGIDRLATGHYARNGFDPETDRHWLARAVDRAKDQSYFLYDLSQEQLASAVFPLGELTKDQTRAIAAELGLSVAHKPESMDLCLVEAAGSMRNFLDNHIDTRRGEIVDTAGKILGEHDGAHHYTVGQRRGLGVAAAQPLYVVAIDAANNRVVVGGREEALTHECIARQVNWVSIAEPTAPIQAMVQVRYRAQPVEATIIPLPENRVRIVFTDAPQFAICPGQAAVWYGGDRVLGGGIIA

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Crispr_ID: NC_022600_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022600_8

4273038-4274931

TypeIII

Consensus_repeat	Method
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CRISPRCasFinder
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	PILER-CR
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CRT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	PILER-CR
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CRT

22 spacers

csx1,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cas2,cas1,csx18

The CRISPR arrays of NC_022600_8

>merge|NC_022600|8|4273038-4274931|CRISPRCasFinder,PILER-CR,CRT,PILER-CR,CRT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAGGCTTATACCGTAACTGGGCTTTATGACGAAGTGCAGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCCGCGCCGAAGCTAAGAGTCGCTACGAGCTCCAGCAGTCTCGTATGACAAACACCCCAGCTTCCAACCCCTCGGTCACGAGTGGCCGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAGGCGTTGATATCGCCGAAGATCGTGGCAAAGCTCTTGCTGTTAAAGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCCGTCCTCCTGTCTTTGGTGGTCTACTTCACCACCTTTTGTCGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAGGTCTGGTCGCGGTAAAGCAATAACGAAAGTAATTCGGAAGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACACCCAGCTGGGCGGCGGCGGAGCGCAGGTATCGATGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCTTACTAATGACCCAGCATAGTTCCGGTGGACAGGGCTCGTTTTGACTCGTTTCCAATCTAATCGTCCGCTCAGGGACGTCGAACGCGTACGTGATTGGGCTGATAGTCTAGTAGCGCGGTTGAGACAGCCGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTTGTTGGCAAGCCCGTCAAGCCTTACACGCCGATGCAGGCGCTGCTTGACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCTGACAGCCACGACCCACCTGACTATACCTACAGCGCGGTGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACGCTGGGGTGCTAAGGGCACGTTCAAGACTGTTGACAACGACGCTGAGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACACCGCCTGCTTGCAGACAACGGCAACGTTCTCACTACCGGTTGACGCACCAATGGCCGACCAAAAGACTACCGACCTTGCAACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCAGCAGCAGCTGATAGATAGCTGGCTTGCGGACTTGCGCAGTGTCTGGAACCACGGCCTAGCTCTGCTGCTGGAGCACGAGAGTTTCAGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCTCAACCGCCGCCAGCTCGCCGTCCCCCATCTCCTCACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTCTATGAAGTTGTCCACCAATTCAACCAACTCAATACGAGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCGACAACACTGGCGTTACCGAGTCGATTTTGCCGTTCAAGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCAACTTCGTGCACAACAGTGCGCGTCACGTAGCGGTTAACAAACCGCTCGAGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACACGCTGAAATTGCATCAGTTTTGATGCCAATCGAATTGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCAACTTGATTGATACGCCCCTCAGCAACGCTTGTACGGTGCAGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACAAGCTTGAAGAACGACATCATCAGCTACTTTCAGAGCGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACTTTTGCACTTTGACAAGATCGTAAGCGGCTGATAAGTTATTAGTTTGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACGGTCCTATCCCAGAAGCTGGTCCCTATGTGCGCAAAGCGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC

>NC_022600|8|8|4273038-4274931|CRISPRCasFinder
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGGCTTATACCGTAACTGGGCTTTATGACGAAGTGCAG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CCGCGCCGAAGCTAAGAGTCGCTACGAGCTCCAGCAGTCTCGTATGACAAACACCCCAGCTTCCAACCCCTCGGTCACGAGTGGCCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGGCGTTGATATCGCCGAAGATCGTGGCAAAGCTCTTGCTGTTAAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CCGTCCTCCTGTCTTTGGTGGTCTACTTCACCACCTTTTGTCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGGTCTGGTCGCGGTAAAGCAATAACGAAAGTAATTCGGAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACCCAGCTGGGCGGCGGCGGAGCGCAGGTATCGATG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTTACTAATGACCCAGCATAGTTCCGGTGGACAGGGCTCGTTTTGACTC
GTTTCCAATCTAATCGTCCGCTCAGGGACGTCGAAC	GCGTACGTGATTGGGCTGATAGTCTAGTAGCGCGGTTGAGACAGCCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTGTTGGCAAGCCCGTCAAGCCTTACACGCCGATGCAGGCGCTGCTTGAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTGACAGCCACGACCCACCTGACTATACCTACAGCGCGGTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GCTGGGGTGCTAAGGGCACGTTCAAGACTGTTGACAACGACGCTGAG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACCGCCTGCTTGCAGACAACGGCAACGTTCTCACTACCGGTTGACGCACCAATGGCCGACCAAAAGACTACCGACCTTGCAAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAGCAGCAGCTGATAGATAGCTGGCTTGCGGACTTGCGCAGTGTCTGGAACCACGGCCTAGCTCTGCTGCTGGAGCACGAGAGTTTCAG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTCAACCGCCGCCAGCTCGCCGTCCCCCATCTCCTCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TCTATGAAGTTGTCCACCAATTCAACCAACTCAATACGA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CGACAACACTGGCGTTACCGAGTCGATTTTGCCGTTCAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAACTTCGTGCACAACAGTGCGCGTCACGTAGCGGTTAACAAACCGCTCGA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACGCTGAAATTGCATCAGTTTTGATGCCAATCGAATTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAACTTGATTGATACGCCCCTCAGCAACGCTTGTACGGTGCA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AAGCTTGAAGAACGACATCATCAGCTACTTTCAGAGCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTTTGCACTTTGACAAGATCGTAAGCGGCTGATAAGTTATTAGTTT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GGTCCTATCCCAGAAGCTGGTCCCTATGTGCGCAAAGC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC

>NC_022600|8|7|4273235-4273911|PILER-CR
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGGCGTTGATATCGCCGAAGATCGTGGCAAAGCTCTTGCTGTTAAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CCGTCCTCCTGTCTTTGGTGGTCTACTTCACCACCTTTTGTCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGGTCTGGTCGCGGTAAAGCAATAACGAAAGTAATTCGGAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACCCAGCTGGGCGGCGGCGGAGCGCAGGTATCGATG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTTACTAATGACCCAGCATAGTTCCGGTGGACAGGGCTCGTTTTGACTC
GTTTCCAATCTAATCGTCCGCTCAGGGACGTCGAAC	GCGTACGTGATTGGGCTGATAGTCTAGTAGCGCGGTTGAGACAGCCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTGTTGGCAAGCCCGTCAAGCCTTACACGCCGATGCAGGCGCTGCTTGAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTGACAGCCACGACCCACCTGACTATACCTACAGCGCGGTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACGCTGGGGTGCTAAGGGCACGTTCAAGACTGTTGACAACGACGCTGAGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACACCGCCTGCTTGCAGACAACGGCAACGTTCTCACTACCGGTTGACGCACCAATGGCCGACCAAAAGACTACCGACCTTGCAACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCAGCAGCAGCTGATAGATAGCTGGCTTGCGGACTTGCGCAGTGTCTGGAACCACGGCCTAGCTCTGCTGCTGGAGCACGAGAGTTTCAGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTCAACCGCCGCCAGCTCGCCGTCCCCCATCTCCTCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TCTATGAAGTTGTCCACCAATTCAACCAACTCAATACGA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CGACAACACTGGCGTTACCGAGTCGATTTTGCCGTTCAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAACTTCGTGCACAACAGTGCGCGTCACGTAGCGGTTAACAAACCGCTCGA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACGCTGAAATTGCATCAGTTTTGATGCCAATCGAATTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAACTTGATTGATACGCCCCTCAGCAACGCTTGTACGGTGCA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AAGCTTGAAGAACGACATCATCAGCTACTTTCAGAGCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTTTGCACTTTGACAAGATCGTAAGCGGCTGATAAGTTATTAGTTT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GGTCCTATCCCAGAAGCTGGTCCCTATGTGCGCAAAGC


>NC_022600|8|5|4273235-4273994|CRT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGGCGTTGATATCGCCGAAGATCGTGGCAAAGCTCTTGCTGTTAAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CCGTCCTCCTGTCTTTGGTGGTCTACTTCACCACCTTTTGTCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGGTCTGGTCGCGGTAAAGCAATAACGAAAGTAATTCGGAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACCCAGCTGGGCGGCGGCGGAGCGCAGGTATCGATG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTTACTAATGACCCAGCATAGTTCCGGTGGACAGGGCTCGTTTTGACTC
GTTTCCAATCTAATCGTCCGCTCAGGGACGTCGAAC	GCGTACGTGATTGGGCTGATAGTCTAGTAGCGCGGTTGAGACAGCCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTGTTGGCAAGCCCGTCAAGCCTTACACGCCGATGCAGGCGCTGCTTGAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTGACAGCCACGACCCACCTGACTATACCTACAGCGCGGTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GCTGGGGTGCTAAGGGCACGTTCAAGACTGTTGACAACGACGCTGAG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACACCGCCTGCTTGCAGACAACGGCAACGTTCTCACTACCGGTTGACGCACCAATGGCCGACCAAAAGACTACCGACCTTGCAACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCAGCAGCAGCTGATAGATAGCTGGCTTGCGGACTTGCGCAGTGTCTGGAACCACGGCCTAGCTCTGCTGCTGGAGCACGAGAGTTTCAGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTCAACCGCCGCCAGCTCGCCGTCCCCCATCTCCTCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TCTATGAAGTTGTCCACCAATTCAACCAACTCAATACGA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CGACAACACTGGCGTTACCGAGTCGATTTTGCCGTTCAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAACTTCGTGCACAACAGTGCGCGTCACGTAGCGGTTAACAAACCGCTCGA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACGCTGAAATTGCATCAGTTTTGATGCCAATCGAATTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAACTTGATTGATACGCCCCTCAGCAACGCTTGTACGGTGCA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AAGCTTGAAGAACGACATCATCAGCTACTTTCAGAGCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTTTGCACTTTGACAAGATCGTAAGCGGCTGATAAGTTATTAGTTT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GGTCCTATCCCAGAAGCTGGTCCCTATGTGCGCAAAGC


>NC_022600|8|8|4274203-4274931|PILER-CR
	AGGCGTTGATATCGCCGAAGATCGTGGCAAAGCTCTTGCTGTTAAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CCGTCCTCCTGTCTTTGGTGGTCTACTTCACCACCTTTTGTCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGGTCTGGTCGCGGTAAAGCAATAACGAAAGTAATTCGGAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACCCAGCTGGGCGGCGGCGGAGCGCAGGTATCGATG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTTACTAATGACCCAGCATAGTTCCGGTGGACAGGGCTCGTTTTGACTC
GTTTCCAATCTAATCGTCCGCTCAGGGACGTCGAAC	GCGTACGTGATTGGGCTGATAGTCTAGTAGCGCGGTTGAGACAGCCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTGTTGGCAAGCCCGTCAAGCCTTACACGCCGATGCAGGCGCTGCTTGAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTGACAGCCACGACCCACCTGACTATACCTACAGCGCGGTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACGCTGGGGTGCTAAGGGCACGTTCAAGACTGTTGACAACGACGCTGAGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACACCGCCTGCTTGCAGACAACGGCAACGTTCTCACTACCGGTTGACGCACCAATGGCCGACCAAAAGACTACCGACCTTGCAACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCAGCAGCAGCTGATAGATAGCTGGCTTGCGGACTTGCGCAGTGTCTGGAACCACGGCCTAGCTCTGCTGCTGGAGCACGAGAGTTTCAGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTCAACCGCCGCCAGCTCGCCGTCCCCCATCTCCTCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TCTATGAAGTTGTCCACCAATTCAACCAACTCAATACGA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CGACAACACTGGCGTTACCGAGTCGATTTTGCCGTTCAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAACTTCGTGCACAACAGTGCGCGTCACGTAGCGGTTAACAAACCGCTCGA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACGCTGAAATTGCATCAGTTTTGATGCCAATCGAATTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAACTTGATTGATACGCCCCTCAGCAACGCTTGTACGGTGCA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AAGCTTGAAGAACGACATCATCAGCTACTTTCAGAGCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTTTGCACTTTGACAAGATCGTAAGCGGCTGATAAGTTATTAGTTT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GGTCCTATCCCAGAAGCTGGTCCCTATGTGCGCAAAGC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC

>NC_022600|8|6|4274203-4274931|CRT
	AGGCGTTGATATCGCCGAAGATCGTGGCAAAGCTCTTGCTGTTAAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CCGTCCTCCTGTCTTTGGTGGTCTACTTCACCACCTTTTGTCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AGGTCTGGTCGCGGTAAAGCAATAACGAAAGTAATTCGGAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACCCAGCTGGGCGGCGGCGGAGCGCAGGTATCGATG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTTACTAATGACCCAGCATAGTTCCGGTGGACAGGGCTCGTTTTGACTC
GTTTCCAATCTAATCGTCCGCTCAGGGACGTCGAAC	GCGTACGTGATTGGGCTGATAGTCTAGTAGCGCGGTTGAGACAGCCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTGTTGGCAAGCCCGTCAAGCCTTACACGCCGATGCAGGCGCTGCTTGAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTGACAGCCACGACCCACCTGACTATACCTACAGCGCGGTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GCTGGGGTGCTAAGGGCACGTTCAAGACTGTTGACAACGACGCTGAG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACACCGCCTGCTTGCAGACAACGGCAACGTTCTCACTACCGGTTGACGCACCAATGGCCGACCAAAAGACTACCGACCTTGCAACGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAACCAGCAGCAGCTGATAGATAGCTGGCTTGCGGACTTGCGCAGTGTCTGGAACCACGGCCTAGCTCTGCTGCTGGAGCACGAGAGTTTCAGGTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CTCAACCGCCGCCAGCTCGCCGTCCCCCATCTCCTCAC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TCTATGAAGTTGTCCACCAATTCAACCAACTCAATACGA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CGACAACACTGGCGTTACCGAGTCGATTTTGCCGTTCAA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAACTTCGTGCACAACAGTGCGCGTCACGTAGCGGTTAACAAACCGCTCGA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	ACGCTGAAATTGCATCAGTTTTGATGCCAATCGAATTG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	CAACTTGATTGATACGCCCCTCAGCAACGCTTGTACGGTGCA
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	AAGCTTGAAGAACGACATCATCAGCTACTTTCAGAGCG
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	TTTTGCACTTTGACAAGATCGTAAGCGGCTGATAAGTTATTAGTTT
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC	GGTCCTATCCCAGAAGCTGGTCCCTATGTGCGCAAAGC
GTTTCCAATCTAATCGTCCGCTGAGGGACGTCGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022600.1\|WP_023175636.1\|4259682_4260672_-\|DUF1517-domain-containing-protein	unknown	unknown	gnl\|CDD\|369378
NC_022600.1\|WP_081705323.1\|4278471_4279017_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NC_022600.1\|WP_041244093.1\|4279514_4279910_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023175645.1\|4275126_4275402_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NC_022600.1\|WP_023175641.1\|4266809_4267607_+\|hypothetical-protein	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl\|CDD\|274210
NC_022600.1\|WP_023175647.1\|4276391_4276616_-\|hypothetical-protein	csx18	cls000006_csx18_CAS-I:CAS-III	gnl\|CDD\|371663
NC_022600.1\|WP_023175652.1\|4280003_4280726_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NC_022600.1\|WP_023175651.1\|4279083_4279518_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NC_022600.1\|WP_023175648.1\|4276636_4277896_-\|hypothetical-protein	csx1	mkCas0109_csx1_CAS-III	gnl\|CDD\|312974
NC_022600.1\|WP_023175638.1\|4262187_4264029_+\|HipA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377920
NC_022600.1\|WP_023175653.1\|4280764_4281823_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NC_022600.1\|WP_023175643.1\|4268016_4269678_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377130
NC_022600.1\|WP_023175642.1\|4267610_4268024_+\|hypothetical-protein	cmr5gr11	mkCas0065_cmr5gr11_CAS-III-B	unknown
NC_022600.1\|WP_041244091.1\|4264341_4265835_+\|hypothetical-protein	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
NC_022600.1\|WP_023175649.1\|4278082_4278358_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|368240
NC_022600.1\|WP_023175635.1\|4259202_4259529_-\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023175644.1\|4269684_4271235_+\|hypothetical-protein	csx1	mkCas0108_csx1_CAS-III	unknown
NC_022600.1\|WP_023175646.1\|4275403_4276399_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|376633
NC_022600.1\|WP_023175640.1\|4265819_4266806_+\|hypothetical-protein	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
NC_022600.1\|WP_041244090.1\|4260837_4262052_+\|acetylornithine-transaminase	unknown	unknown	gnl\|CDD\|235056

Protein	Function_ID	Function_description	E-value
NC_022600.1\|WP_023175636.1\|4259682_4260672_-\|DUF1517-domain-containing-protein	gnl\|CDD\|369378	pfam07466, DUF1517, Protein of unknown function (DUF1517). This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.	1.88456e-79
NC_022600.1\|WP_081705323.1\|4278471_4279017_+\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	3.15272e-09
NC_022600.1\|WP_023175645.1\|4275126_4275402_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.61705e-29
NC_022600.1\|WP_023175641.1\|4266809_4267607_+\|hypothetical-protein	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	4.92348e-23
NC_022600.1\|WP_023175647.1\|4276391_4276616_-\|hypothetical-protein	gnl\|CDD\|371663	pfam11674, DUF3270, Protein of unknown function (DUF3270). This family of proteins with unknown function appears to be restricted to Streptococcus.	0.00978937
NC_022600.1\|WP_023175652.1\|4280003_4280726_-\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	1.85145e-19
NC_022600.1\|WP_023175651.1\|4279083_4279518_-\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	3.75999e-10
NC_022600.1\|WP_023175648.1\|4276636_4277896_-\|hypothetical-protein	gnl\|CDD\|312974	pfam09659, Cas_Csm6, CRISPR-associated protein (Cas_Csm6). Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	3.62155e-09
NC_022600.1\|WP_023175638.1\|4262187_4264029_+\|HipA-domain-containing-protein	gnl\|CDD\|377920	pfam07804, HipA_C, HipA-like C-terminal domain. The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.	7.04056e-47
NC_022600.1\|WP_023175653.1\|4280764_4281823_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NC_022600.1\|WP_023175643.1\|4268016_4269678_+\|hypothetical-protein	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	1.91418e-05
NC_022600.1\|WP_041244090.1\|4260837_4262052_+\|acetylornithine-transaminase	gnl\|CDD\|235056	PRK02627, PRK02627, acetylornithine aminotransferase; Provisional.	0
NC_022600.1\|WP_041244091.1\|4264341_4265835_+\|hypothetical-protein	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	2.48955e-12
NC_022600.1\|WP_023175649.1\|4278082_4278358_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	8.99625e-09
NC_022600.1\|WP_023175640.1\|4265819_4266806_+\|hypothetical-protein	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	5.87688e-07
NC_022600.1\|WP_023175646.1\|4275403_4276399_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|376633	pfam01867, Cas_Cas1, CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.	9.76132e-105

>NC_022600.1|WP_023175644.1|4269684_4271235_+|hypothetical-protein
MSLWIVTVGSSDVQLSSRSNWYTLFEKVRSELECEEFSPQEVESEAAERRYVVPGRVLGLVYGTSSKHEDLVFPLLDAYTSRLLPLQPPSKVVFLLTDQSNLALERRLPQSPYWQDTCTLAPLLAAYIHRRLNLEPQMLILTPPKGGRGIDHWDATLKLVGEQLMQLTTKLHEPVYVSHQAGTPALSSAVQFMSLSQFGEQVRFLVVNRFDSGEPVECIESSRYLRGIRAQEARRLVVDGIPGAALNLLTVSDSEATFRHPELVKLVNFFNLRSTGTGREKDFDLDQVAQRLFEALELISIFFHQRNYLTGITLLAAAHELFLKAAVIRALTTRSEIVIRGNSLLLNQLIEWNEYGLRLKKSELLIRFGLPDDKDGKNWGGLKEGIDKCLNYPKPALNRRFFDANANLLPWLKALRADFVSWPLLNWICDDKRSTEQDLRNQLMHNLRGIEEEDVVRYLLAGKQAEIGESPASTYRVKILEPFLAALELVGSVDKDAVLLDHRLNETAKHLVHYSL
>NC_022600.1|WP_023175643.1|4268016_4269678_+|hypothetical-protein
MDSNKVPQLFRAQVEGRCQLQNPRTDDAQRWAYEWIAKADRRAPAFSRTVRQRRYRITWRFVTNGGQDDGVIRPVLGARGWPYYPGSSMKGAFRSACRQAAPDKVIRYCGGSDGQGGWRPGILRFHGGYPANADWQQRERLVDLVHPQEGVQVEASSSRHSAFALFSLYRPELRFALSSNKPLEDVEWTEIWSIWEKALSHGIGSRVSAGYGRVVREQDGERELLVADPLVSVHLTGQGQASYLLTKASPRPAEFRPNMFKAALRGHTRRLFGGFVDEATAEELTYELWGGIQGKAKAGLLGVVFNGEAELGTHGRGSFAVPTYTVKDGWLRVVQTRDIPDERCHELIKLVARLMQFSLLLGGFGKSWRRVDHRLFYPQYYTDSNKPLIGCHWKLSEKKLHPVYVTINDLQDVGKAIEKIRNQCHRWIMSHPNIKLREKPCHWREAWHADKVQVWGRVASDKADSRAVSWFHGPYQNQATIKGSELTGRLGAIGRIWHRMYPRVIREADHLVAKPEFVELLTLFPDSSQQTQRFINFLATPQSGFTKLWPFEE
>NC_022600.1|WP_023175642.1|4267610_4268024_+|hypothetical-protein
MSWQSYQLDRAAQELVLRHRDKGVLNQSYKMRQAAAFGLERFWGEHVRLMKEDATAAGYWKQTWDSLVTILKKAGLELPNHTIKDPKKTQDIQAMADELWKLSPQKQRVALAVLVQFCDCLIWWTQRYKTGKEKSDG
>NC_022600.1|WP_023175641.1|4266809_4267607_+|hypothetical-protein
MYSRAYGVIEALAPLHVGASAGEESGNLNLIFRDQFTQTGIVPGSSIRGRLRAEMRQAGEQDEQEWYGRGTDAGRTDGMSESAVKFEYASLIWLPVFCPGQPIVWVSCPRLLARYQRIAGMQGELPRPYTGSKDLQGIDGKDVLFFNLGFLTLKRKEDLSAWFPERRARPAVVVEDSDMAVIHDMALYRQSRVKLHDEVKVVDGGAFFNVEALPEETLLVFPVAIKPTTNGKTWQPFSDGMSAEIYLGGLESIGFGHCRVTIYGV
>NC_022600.1|WP_023175640.1|4265819_4266806_+|hypothetical-protein
MFQYVITVEPLGLLYGSAGAFLSPANLVGRAGRRFPPDAPTLSGLYYNGASEALRRELGEKLHLAGPFWAEQEDPLNFYVPIPWTRVVGEDSSDEWTIADHHWQRTDPDLKPAYRWQPINSWKAPLRNLQKNQARKDPWQFVPALHPHLKDDERCVPEQDGLFLENAAQMCPGTCLVYLASHPLSAGWYRFGGESHVVQIGCRDLPERSKAMALLAEPIDRAFALLTPGIWGSNRFSLRHPQHPDFPKPVLMLTEKPVPFRYRIAEQLGRGRYAVPAGSVYVLSQPLDQPWRDWNSDWFPREGHSYKRWGCGLALPLEIEGLQTLQGV
>NC_022600.1|WP_041244091.1|4264341_4265835_+|hypothetical-protein
MSALYTVFTFAPVQGFIEKSRKLRDLYGASIILSYLTFRLTEKAEAAEGVQVISPGMPNVQEGMPNRIVLSGVVTVEEYQKAFFENWRRMLREVRDWIERQLPAYEYCWRDEWQHWGNHAWEFFWGQGASVPEAVNDLEARKLARSWTGINWTGESSSLSGTDAIAWPGLGRVVDVRSRKLNQEKQQIQLFYSELAKRLDPQGEGKFLAENEQLSIPELTKRLVTRHDLARSLGMTELEAGFTDLAREQDKGTWTGWLMGDGDKIGNYLKDLARSEDGGALRHFSEAMREWGRSFARDFAQEKLGRVIYAGGDDFLAVFYRPQKKLLPGEVIDWLCNFPKIWRQHGQKVTVSAGFVWAAPRVPQRDVLQHCREAEQLSKAAGRDRLTLRVVFNSGQYVQWTCPWEYLKTLMERRNQVDWTRLYKDLAELQARHAFEENHESADPRVALALFDIYFPRQGEYLNAHRTLVHKDKFSGQAINSWISDLIRVGWHLCSNT
>NC_022600.1|WP_023175638.1|4262187_4264029_+|HipA-domain-containing-protein
MALYLIGLNLDSPTAHYRAERGYLVQLLRGIYVDATDDVDAVVLQHAVRIAKYLYPNTYLSAASAILLGPTADGRLFLSGRRKQRTRIRTLEIIQNQAPAYPSVAPTLVKDSLGEISVDVSAIRQSLLEAFRRRSEQSASIDPAMKQALVERLVSEYGSPSKAADAVWALARENQWYREGEEAEQWLLRQPPIVVSNAETGITFHITWHGVPLGRLRNDGFEWRWLLEKVDLISPVRDTVPGQLPPFISSLLPEGWTEEVLQTDDEREVLLGGRRYLSNIAIVDDLAKLASLPVDVLDGRLARWMQEGRFVGAYAGPGRGHIAKGFEWAVAELYRDRDTPRLSGVQIKAPMYLNALGQLLDARGRPFTHILKPAGAAGFEATPIVEWTALELAKRMEFVVPAHALVEMPEQLPPALVVERFDIRCGLEDNQQLYCQEDFCSLLNISSAKKYGSTIEQVAKTLRSVSTEPEADLLLLWRRALFAWLIADGDMHLKNLAVLRIAVPGERSFLSVRLAPVYDTLTTRVFPGMAQDRMALKLNGKNDRLQASDFLTLARTIGIKVSTAEQALAQMTSKLASAVRDICLPALAYYGPQGLEKFTQLQQIVETRCKKMA
>NC_022600.1|WP_041244090.1|4260837_4262052_+|acetylornithine-transaminase
MKTVETVRQAFEEHVMHTYARFPVVFERGEGCYLEDSEGRRYLDFVAGIATCALGHAHPVLGAAIAEQARTLIHVSNLYYTRQQGELARWLTDNSVADQVFFCNSGAEANEGAIKLARKYGRTVLGIAEPQIISTHLSFHGRTLATVTATGQPKYQKHFHPLVPGFVHVPYNDFDALRAQVTDATCAVLIEPIQGEGGVMPGDVDFFRKLRRFCSEQRILLILDEVQTGMGRTGKLWGYEHLGIEPDIFTLAKALGGGVPIGALCAKAEFSLFEPGDHASTFGGNPLACAAGLAVCQTLEAEALVENARVRGEQLAAGLKRIAERFGSLVRLSRGRGLMQGLVLVAPRAAEVVRLAMDEGLLLVSAGPEVVRLVPPLIVSAIEIDEALAILEGVLARLPVTVTA
>NC_022600.1|WP_023175636.1|4259682_4260672_-|DUF1517-domain-containing-protein
MARITSLMRGVLAGGLALGLLLSGTGSFQSSDVAWARGSSGGRIGGGSFRSAPRSYAPAPRYAPGGGYGGGYYSPGPVVPVPVPIPFGGGYGYGYGYGGGFGLSSIFVIVIVVGAGLFFLRFIRRNAAGVGDYGGYDGEPIDSGKIDVFRLQVALLATAKQLQRDLIRLAEQSDTSTPEGLTRLNQEVTLALLRNPEYWVYAKSDAQELPRLQAESQFNRLALAERTKYTDEVVSKTGSTGLVQKKFDGENPDEVAEYIVVTLLVATEDGAPRLLNVRSSDDLRQALTILGSLSSEQIVAVEVVWSPADENDTLTSDELLTQYTDLVRL
>NC_022600.1|WP_023175635.1|4259202_4259529_-|hypothetical-protein
MPTNNPKISAYVPQYVFDRFKQYEKEQGLSMSQAVADILIRYFELTPARRPAAPPAIPAEVVERIASLERKVELLEKIAIPAPASLNSPLTFTSEAAGPDDADPAPSK
>NC_022600.1|WP_023175645.1|4275126_4275402_-|CRISPR-associated-endonuclease-Cas2
MLWVVAYDIPVTKRRNKIAKLLEGYGKRVQYSVFECDLEESQFSELRNRLLKLLKLPDDSLRYYPIAANMTRKIVILGGDGLYEKPDHFAV
>NC_022600.1|WP_023175646.1|4275403_4276399_-|CRISPR-associated-endonuclease-Cas1
MSSLYLLEQGIWVGKDGEQLAIHRKREVVRQIPLPLIDRIFVFGRIHLSIEVLRTCLRRRIPLALLSRQGWLYGTLSPPQQGRLHLRRAQQRVQEESERSLRLAQSLVEAKIHNQRVLLQRLNRRRPIAENEFAVDVLRYLESRVPQTSNIAALLGNEGAAAAQFYPAYGRQLQDSEFRLVERIRRPPTNPANAVLSFGYSLLWNHVRAVVELHGCDPYLGHLHVPRDDHLALISDLIEPFRTPIIDSLVLTMVNRRMFTSEDFEYANGACFLADSGRRKFVTQFQQIMGETIQLPNGRDGVRWKLIDQGVENYKTALQNPELPFNVYRIR
>NC_022600.1|WP_023175647.1|4276391_4276616_-|hypothetical-protein
MNSARLLFFRNVAVASVNTAVTLVILLIAPLGLAAVLTCTVAVGLSSLIIGLCADQVARWLFSDGGLAVRAPRE
>NC_022600.1|WP_023175648.1|4276636_4277896_-|hypothetical-protein
MVSVVVSFVGKQDPSSERPGYPTNQEGSLVTLTRYLQGQGLTVGGVVLLYTADQVERMELCREWLVQDLYLEAATVMALPVNEVLSTDPIDIQAAITEARRGIELASMALCAADRIELNASSGTPAMKSAWNLLQAAGYVPNARVWQVRDPTQMSVAQARVFESDTSYLRDEFDAKVLARQIADFNYAGALDSLAQSHLETPQLTGLLRFGRFRLAFDFNRAHAALADVDSPLRNELMREITPLRQRRPPVLLRELYFNALVRFATCEYSDFLGRVFRFQEAVMQLVVEERCGLTLLNRNHWQVIDQIDGGKLRKYLDGYRLPGGGRLQLNSDFNRRILEAILEYFNQDILLLHLRVINSYGDLRNRCIVAHGYEGLSEIRGSEHLTQTMGKILLEIGIISGKHPFEVLNSHILRILRM
>NC_022600.1|WP_023175649.1|4278082_4278358_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MEVRWTDKSLVDLNRLHAFLRPTNPQAAARVVRSLIAAAKRLEQFPQLGTALPEFAPRNVRRLIVADYEMRYELKDDALFILRVWRAREDR
>NC_022600.1|WP_081705323.1|4278471_4279017_+|Uma2-family-endonuclease
MAALFLFDKIRQRLPDIPPVVPDGFLSLEVERVFDEDLRLSYVLWEELKVPTLVLKVVSKTRNKEYRQKKALYAELGVPYYVIYAPRRRRKEHLEIYRLVEEPYVLLPGQPAWIEELGLGIGRERGTYEGVTREWLYWYDRDGKRYATPEERLAQAEEQVERNRERIRALEQKLRESGIEP
>NC_022600.1|WP_023175651.1|4279083_4279518_-|HNH-endonuclease
MSSGYISEELRERVRQHAQDRCGYCLSPQKYVLGRLEIEHIIPLAYGGTNEEENLWLSCRLCNSYKGTQVRARDPITGRSTKLFNPRTQRWSRHFRWSPDGTRVIGYTVCGRATVIALQMNNLIAVTVRQQWELAGWHPPVDLP
>NC_022600.1|WP_041244093.1|4279514_4279910_-|hypothetical-protein
MTTRITLDVPDEIYRRAQDLAQVSGREVREVLSEALALSLAPVSPAPESGDFTAAEKLSDEQVLALCELQLPEQQDQHLSELLNRQQAGMLGEFERLELAGLMQIYQFQLLRKAQALREAVQRRLLPPLSP
>NC_022600.1|WP_023175652.1|4280003_4280726_-|Uma2-family-endonuclease
MYQPNPAADVIWPPTDLWSDEPPMESDWHRKQMQVLIESLESHWRDRQNFYCSGNLTIYYSLTQRKSEDFRGPDFFVVLGCERRERRSWTVWEEGGRLPNVIVEILSESTAEIDRGLKKQIYQDVLRVPEYFWFDPQSQELCGFHLVEGQYEPLEVSESGRLWSGQLELFFGVPEDRLRLLTADGTVIPTPMERALEAEQQVLQEQQRAVQAEQQVVQERQRAERLAQRLRELGLDPDAL
>NC_022600.1|WP_023175653.1|4280764_4281823_-|tRNA-2-thiouridine(34)-synthase-MnmA
MTAGIKLAAALSGGVDSSVAAALVRQQGYRVLGITLWLMRGKGSCCSDGMKDAARVCEQLGIAHHIVDVREQFEETIVDFLVTGYQQGVTPLPCSRCNKELKFGLLLDYARHKLGIDRLATGHYARNGFDPETDRHWLARAVDRAKDQSYFLYDLSQEQLASAVFPLGELTKDQTRAIAAELGLSVAHKPESMDLCLVEAAGSMRNFLDNHIDTRRGEIVDTAGKILGEHDGAHHYTVGQRRGLGVAAAQPLYVVAIDAANNRVVVGGREEALTHECIARQVNWVSIAEPTAPIQAMVQVRYRAQPVEATIIPLPENRVRIVFTDAPQFAICPGQAAVWYGGDRVLGGGIIA

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Crispr_ID: NC_022600_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022600_9

4330803-4330988

Orphan

Consensus_repeat	Method
GAATCCACCGTCGTCGTCTTGCCGTTCGGGCCGGT	PILER-CR
ACCGTCGTCGTCTTGCCGTTCGGGCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_022600_9

>merge|NC_022600|9|4330803-4330988|PILER-CR,CRISPRCasFinder
TTGCCCTTCGGGCCGGTCACGGAGCTGTCGCGGGTGAAGCCGCCTTCCGGATTGCGGGTGAGGGTCGAATCGACCGTCGTCGTCTTGCCGTTCGGGCCGGTGATCGTCTTGTCTTTAGTAAAACTGCCGTCGGTGTTTTTGGTCACCGAGGAGTCCACCGTCGTCGTCTTGCCGTTCGGGCCCGTA

>NC_022600|9|9|4330803-4330988|PILER-CR
TTGCCCTTCGGGCCGGTCACGGAGCTGTCGCGGGTG	AAGCCGCCTTCCGGATTGCGGGTGAGGGTCGAATCGACCGTCGTCGTCT
TGCCGTTCGGGCCGGTGATCGTCTTGTCTTTAGTAA	AACTGCCGTCGGTGTTTTTGGTCACCGAGGAGTCCACCGTCGTCGTCTT
GCCGTTCGGGCCCGTA

>NC_022600|9|9|4330875-4330984|CRISPRCasFinder
ACCGTCGTCGTCTTGCCGTTCGGGCC	GGTGATCGTCTTGTCTTTAGTAAAACTGCCGTCGGTGTTTTTGGTCACCGAGGAGTCC
ACCGTCGTCGTCTTGCCGTTCGGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022600.1\|WP_081705326.1\|4328137_4328530_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|368240
NC_022600.1\|WP_023175693.1\|4324410_4325166_+\|sucrose-phosphate-phosphatase	unknown	unknown	gnl\|CDD\|368291
NC_022600.1\|WP_187293848.1\|4329493_4330612_-\|retroviral-like-aspartic-protease-family-protein	unknown	unknown	gnl\|CDD\|133150
NC_022600.1\|WP_023175695.1\|4325625_4326066_+\|DUF488-domain-containing-protein	unknown	unknown	gnl\|CDD\|377317
NC_022600.1\|WP_023175711.1\|4336139_4337021_-\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|235107
NC_022600.1\|WP_023175692.1\|4323162_4324407_+\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340830
NC_022600.1\|WP_023175697.1\|4326099_4326792_+\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_023175702.1\|4328550_4329468_-\|histone-deacetylase	unknown	unknown	gnl\|CDD\|212518
NC_022600.1\|WP_023175700.1\|4327884_4328160_+\|trifunctional-transcriptional-regulator/proline-dehydrogenase/pyrroline-5-carboxylate-dehydrogenase	unknown	unknown	gnl\|CDD\|226420
NC_022600.1\|WP_023175706.1\|4331572_4333306_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_022600.1\|WP_023175715.1\|4342533_4342911_+\|hypothetical-protein	unknown	unknown	unknown
NC_022600.1\|WP_144080527.1\|4326794_4327448_-\|DNA/RNA-non-specific-endonuclease	unknown	unknown	gnl\|CDD\|224777
NC_022600.1\|WP_023175708.1\|4333414_4334320_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|178419
NC_022600.1\|WP_187293849.1\|4338161_4341512_-\|response-regulator	unknown	unknown	gnl\|CDD\|236848
NC_022600.1\|WP_023175712.1\|4337017_4338031_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NC_022600.1\|WP_023175694.1\|4325231_4325621_+\|DUF4326-domain-containing-protein	unknown	unknown	gnl\|CDD\|372965
NC_022600.1\|WP_023175709.1\|4334305_4336093_-\|ribonuclease-J	unknown	unknown	gnl\|CDD\|223668
NC_022600.1\|WP_023175714.1\|4341544_4342360_-\|chemotaxis-protein-CheR	unknown	unknown	gnl\|CDD\|224271
NC_022600.1\|WP_023175717.1\|4343996_4344701_-\|DUF2490-domain-containing-protein	unknown	unknown	gnl\|CDD\|378471
NC_022600.1\|WP_023175716.1\|4342951_4343968_+\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|184688

Protein	Function_ID	Function_description	E-value
NC_022600.1\|WP_081705326.1\|4328137_4328530_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	2.00956e-12
NC_022600.1\|WP_023175693.1\|4324410_4325166_+\|sucrose-phosphate-phosphatase	gnl\|CDD\|368291	pfam05116, S6PP, Sucrose-6F-phosphate phosphohydrolase. This family consists of Sucrose-6F-phosphate phosphohydrolase proteins found in plants and cyanobacteria. Sucrose-6(F)-phosphate phosphohydrolase catalyzes the final step in the pathway of sucrose biosynthesis.	2.92347e-89
NC_022600.1\|WP_187293848.1\|4329493_4330612_-\|retroviral-like-aspartic-protease-family-protein	gnl\|CDD\|133150	cd05483, retropepsin_like_bacteria, Bacterial aspartate proteases, retropepsin-like protease family. This family of bacteria aspartate proteases is a subfamily of retropepsin-like protease family, which includes enzymes from retrovirus and retrotransposons. While fungal and mammalian pepsin-like aspartate proteases are bilobal proteins with structurally related N- and C-termini, this family of bacteria aspartate proteases is half as long as their fungal and mammalian counterparts. The monomers are structurally related to one lobe of the pepsin molecule and function as homodimers. The active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. In aspartate peptidases, Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate proteases is classified by MEROPS as the peptidase family A2 (retropepsin family, clan AA), subfamily A2A.	6.96522e-17
NC_022600.1\|WP_023175695.1\|4325625_4326066_+\|DUF488-domain-containing-protein	gnl\|CDD\|377317	pfam04343, DUF488, Protein of unknown function, DUF488. This family includes several proteins of uncharacterized function.	2.2009e-21
NC_022600.1\|WP_023175711.1\|4336139_4337021_-\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	2.45863e-164
NC_022600.1\|WP_023175692.1\|4323162_4324407_+\|glycosyltransferase-family-1-protein	gnl\|CDD\|340830	cd03800, GT4_sucrose_synthase, sucrose-phosphate synthase and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.	6.00075e-173
NC_022600.1\|WP_023175702.1\|4328550_4329468_-\|histone-deacetylase	gnl\|CDD\|212518	cd09992, HDAC_classII, Histone deacetylases and histone-like deacetylases, classII. Class II histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. This group includes animal HDAC4,5,6,7,8,9,10, fungal HOS3 and HDA1, plant HDA5 and HDA15 as well as other eukaryotes, archaeal and bacterial histone-like deacetylases. Eukaryotic deacetylases mostly use histones (H2, H3, H4) as substrates for deacetylation; however, non-histone substrates are known (for example, tubulin). Substrates for prokaryotic histone-like deacetylases are not known. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Interaction partners of class II deacetylases include 14-3-3 proteins, MEF2 family of transcriptional factors, CtBP, calmodulin (CaM), SMRT, N-CoR, BCL6, HP1alpha and SUMO. Histone deacetylases play a role in the regulation of cell cycle, cell differentiation and survival. Class II mammalian HDACs are differentially inhibited by structurally diverse compounds with known antitumor activities, thus presenting them as potential drug targets for human diseases resulting from aberrant acetylation.	4.65245e-141
NC_022600.1\|WP_023175700.1\|4327884_4328160_+\|trifunctional-transcriptional-regulator/proline-dehydrogenase/pyrroline-5-carboxylate-dehydrogenase	gnl\|CDD\|226420	COG3905, COG3905, Predicted transcriptional regulator [Transcription].	6.06079e-11
NC_022600.1\|WP_023175706.1\|4331572_4333306_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	6.30345e-05
NC_022600.1\|WP_144080527.1\|4326794_4327448_-\|DNA/RNA-non-specific-endonuclease	gnl\|CDD\|224777	COG1864, NUC1, DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism].	2.37702e-71
NC_022600.1\|WP_023175708.1\|4333414_4334320_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|178419	PLN02824, PLN02824, hydrolase, alpha/beta fold family protein.	1.00755e-91
NC_022600.1\|WP_187293849.1\|4338161_4341512_-\|response-regulator	gnl\|CDD\|236848	PRK11107, PRK11107, hybrid sensory histidine kinase BarA; Provisional.	2.39688e-60
NC_022600.1\|WP_023175712.1\|4337017_4338031_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	4.03093e-180
NC_022600.1\|WP_023175694.1\|4325231_4325621_+\|DUF4326-domain-containing-protein	gnl\|CDD\|372965	pfam14216, DUF4326, Domain of unknown function (DUF4326). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 100 and 162 amino acids in length. There are two completely conserved residues (P and C) that may be functionally important.	2.95994e-25
NC_022600.1\|WP_023175709.1\|4334305_4336093_-\|ribonuclease-J	gnl\|CDD\|223668	COG0595, COG0595, mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair].	0
NC_022600.1\|WP_023175714.1\|4341544_4342360_-\|chemotaxis-protein-CheR	gnl\|CDD\|224271	COG1352, CheR, Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms].	8.69516e-52
NC_022600.1\|WP_023175717.1\|4343996_4344701_-\|DUF2490-domain-containing-protein	gnl\|CDD\|378471	pfam10677, DUF2490, Protein of unknown function (DUF2490). This is a bacterial family of uncharacterized proteins. They appear to belong to the outer membrane beta barrel superfamily.	1.52004e-40
NC_022600.1\|WP_023175716.1\|4342951_4343968_+\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|184688	PRK14457, PRK14457, 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN.	0

>NC_022600.1|WP_187293848.1|4329493_4330612_-|retroviral-like-aspartic-protease-family-protein
MFALAGVHSPVRAQSDLGAALFAQIQQCLVKKLPNLQRAKSEALSAASQQCFFNVVVLDERGARRIDANERTLAVLQTSGVRLPVRSGEGEATVPLGKLLLRSQSTGVYTVAVTIAGRKQDFLLDTGADSTIISAALARQLRLPSSPVPIPGEVFSQGVIGHSRRSGRVEASAYYLPVLGVGTARLQQLMAVSLPLAYIPGQKAGILGLNAISAFDMVIDPRIPELRLLRPSAPPAGAIPLTGQSGLLTAAVTIAGAGPFRFALDTGAGVSLLSKNLARQLALDTTPSRTVNLLGFGGSQGGQLVTLPGLSLGPVSLANVQAVVLATPLLDQTGLDGLVGQNFLNHFRQHWRFAPPNPLGIVPEGTLELERQ
>NC_022600.1|WP_023175702.1|4328550_4329468_-|histone-deacetylase
MNTLPVIYTERFLEHDTGPWHPERPERLVAVVEHLRAAPFSSRLIWREPRAASPEQLGWIHDASLIKTVEAASKKGGGALDPDTIVSPLSFDVALLAAGGWLDGVDAVLSNNEPAWVLARPPGHHAERDRAMGFCLFSNAALAAHYALRVHHLERVAVLDWDVHHGNGTQQLCWSEPRLAYVSLHQSPQYPGTGHTGETGGSGNVLNVPLPAGSDRSTYQRAFTKQIWPFLERFEAQLLIVSAGFDAHSADPLAEMCLQASDYGEFARQCLNYTRRVLFGLEGGYDLDALAASVLAVTEACLQPI
>NC_022600.1|WP_081705326.1|4328137_4328530_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MSSRAPNSPELSNRGERLIFRGLKRRAFVNNSQNDRSGIVWLPEAVEDTGRLINFLQEKNPEAAVRAAQALQKGTNTLSTFPELGHSMNDGTERREFFIPFGAGSYVLRYIISEQTLVIVRVWHSRENRK
>NC_022600.1|WP_023175700.1|4327884_4328160_+|trifunctional-transcriptional-regulator/proline-dehydrogenase/pyrroline-5-carboxylate-dehydrogenase
MSKIVNTGVKLDETLHNRLKQLGVLKARTPHWLMRTAIEEYVEREEAYEREKQEDVERWQRYQTLNHAIPHEQVSAWLGSIGTGNEQPCPK
>NC_022600.1|WP_144080527.1|4326794_4327448_-|DNA/RNA-non-specific-endonuclease
MLKPQYALSYNATKGIPNWVSWQLNRSWLGTSDRQNDFRPDRSLPPGYGRIAPSDYTGSGYDRGHQCPSADRTRSIQDNSATFLMTNMIPQAPDLNRGPWEKLESYSRTLASEGKELYIVAGVAGTQGTIGGRVSVPASSWKVIVVLDRPGLGLAGINKNTRVIAVLMPNQAGIKQSSWRRFRVSVDQIEKETGYELLSSLPEDVQAVIEGQSDRSR
>NC_022600.1|WP_023175697.1|4326099_4326792_+|hypothetical-protein
MPRFEILCLANSRKYQARCIAGLRYDRQGWLRPIGTAEKGALTVEECSYPDGSEPKILDRISVELIDVCPEWHQPENWTAVAGSFRCVSSPDGKVRLDRLQRRLEPGPELLGSQTNHIEQAHFSAANPAQSSLALVLPEQIFWYWKLTGKGKRQVRVRFRLAQARYDLAVTDPAWEERCSVIEEPDTLYTNEDIGYCPDANSRLLFTVSLGQPYNGHYYKLVAAVFAVPV
>NC_022600.1|WP_023175695.1|4325625_4326066_+|DUF488-domain-containing-protein
MSTVYTIGFTKRSAASFFNTLRSIGIKRLLDVRLSNTSQLAAFAKKDDLAFFLEAICKAEYRHEPLLAPTAQMLTAYRSGKCNWEDYQRRFLALMHQRQVEKRIDPTVFDLPTVLLCSEFTAEHCHRRLALEYLQQCWESLLIKHL
>NC_022600.1|WP_023175694.1|4325231_4325621_+|DUF4326-domain-containing-protein
MQIRVINKHYEPVAGEYIGRPSVLGNPFVLGQDGNRQEVIEKYRRWLWQKLKQGGPVLDELCRLQQLAYQRELVLVCWCKRPDREVACHGDVLKQAIEWLDRRERGVSEPGVQAQLPNAVAQQLSLLEL
>NC_022600.1|WP_023175693.1|4324410_4325166_+|sucrose-phosphate-phosphatase
MATGKWLIVTDLDDTLVGPCPEDREALRQLNRHLQPPEIVLVYATGRSPASAQALIAEAGLLAPAALISGVGTAISYEQSPEQADQDWWQRLKVNWDMALIDKIALGHADSLIPQPAGEQNPFKRSFFLAPEQAKTVISTLRAQLAAAGIEAQIVYSSDRDLDILPIGAGKGQAVRHLQERWGFTASTTVVCGDSGNDQGLFETGSLGIAVGNARAELVRWLDINEHLPIYRARQRCAAGLLEGLQHWQVL
>NC_022600.1|WP_023175692.1|4323162_4324407_+|glycosyltransferase-family-1-protein
MYGRIALVSVNGDPSAVIGAEEAGGQNVYVREVGRHLASLGYEVDMFTRRIDKTQPEIVEEAPNCRTIRLAAGPLEFVRRDDLHTYIPHFIESLTPYVKRRGYTAIHTHYWHSGIVGLAMGDRFGVPVVHTYHSLGAIKYMNVAEVPPSAQLRLSGERRILEQADRVVATSPQEAEHMRSYVSHKGLIDIIPCGVDVSHFSRVDRAQARQELGFDENEKVVLYVGRFDKRKGIETLVRAVAQMSEPVRLVIGGGYTSDRGDGQEFERIRSIVDEVGIADRTRFAGRIDQADLPAYYTAADVCVVPSHYEPFGLVAIEAMACGTPVVASAVGGLCYSVVDGQTGLLVPPHDADRFAAAIGRIIANPNLRSELSRASVQRIHSHFTWAGVSRRLGRLFEHLAARKLKVRAASQSVA
>NC_022600.1|WP_023175706.1|4331572_4333306_-|tetratricopeptide-repeat-protein
MSDEHFERIIAQARTARSPAAIAHLLKPVLFEMAPEFEIFLERLVATTPSESSAARTLRLIARVWRELQSANERELQLRQFIRELASAGTEEWPALLVNGMDPNGRLALSDDEWQKVAALLEKREGLPVELAVSLRQSLAVYLRIEANLLDWLYTGNSTLGFTRTGPWGSWAALLPVGTARTLLEALDRGESARDFLAAESLDALGWIELTVLLRRIERHLVRSFEQRYPNLPATSRVAVLASTFLTFAIFWADFAQALVRQSALSEASFQNALQILRAFASQPYFPLYGGLLAIFDGPYLRAALTYMGEPLRLGSTPIEKAKLLNLLGYTARLLGDYPRSLALHREALEALEGESDPRVRVANLINQGSTQLRLREFAAASELFERALVYARQVGDRTGQAHALANLGNAYSLALQFEEVLDPERYELAAAYLQQGLEASRQAKERPAEMVALTGLGALQLFLNRAEEALPLLEQSLQLASGLGDLWWEGTARAALAEALVNLDRPLLAVGQAAIAMLTLDRVGSIDWRQPASLLVVLRTRLGDDFNQALQAAKLGEGALGRVEALLRLYLEPRSS
>NC_022600.1|WP_023175708.1|4333414_4334320_+|alpha/beta-fold-hydrolase
MLADLKPTSTVESFWQWRAHRICYWQAGPGDTDEAPVVLLHGFGGCVGHWRKNIGELATGRRVYALDWLGFGASDKPDVRYSIDLWQEQLIDFCEQVVGTPAVLVGNSIGALVALSTTAHRPERVAATALLNCAGGLTHRPEELPLLVRPIMGAMQVVLRIPGLAERFFDYARSKHNIRNTLRQVYGNGEAVSDELVEMLYRPSTDPGAAKVFVSVLTAEAGPTPEELLPLVRTPLLILWGEKDPWTPIARGRTFSDYAPQARFVALPGLGHCPHDEDALRVNAILKEWLASIDSGALRGE
>NC_022600.1|WP_023175709.1|4334305_4336093_-|ribonuclease-J
MAENLNTHTTSPLKIIPLGGLGEIGKNTWIFQYNDEIMLLDGGLSFPTEEMHGVNLVLPNIDWLIENQDKVMGMVVTHGHEDHIGGIPYHLQRLRIPVIYGPRLALALLGDKLKEAELLNRTELVSVGPRSTVRVGKYFLVEYLQNTHSIADSYTLAIHTPVGVVIHTGDFKFDHTPVDGRKFDYQKLAEHGEKGVLCLISDSTNAEVPGFTPSERSVYPNLERYIKEAPGRVIVTTFASSVHRINMLLEIAQKTGRTVSVVGHSMLNMIAKAKSLGLLADFPESLLQPVPVTNGLPPEQVLVLTTGSQGEPMSALTRISKGEHRQVKIKTGDTVIFSANPIPGNTISVVRVVDRLMQLGANVIYGKERGIHVSGHGAIEDQKLMLALTRPRFFFPCHGEYRMIRRHAQTAREMGVPAENIVLTENGDVVGLTPEAIRIVDKIPAGIDLVDASRSSMVNDNVLKERQRLAEDGFVAVAIALTPQATFAARPQIAVKAVARSAETRNLEDVIRTALVRAQERFGEFRLPGEAGEPEQYDWMAIRQLLERTVKQVIREMLQSYPLIQVLLQTPQVDSAAVLPSLPPVRGEAEALLAP
>NC_022600.1|WP_023175711.1|4336139_4337021_-|4-hydroxy-tetrahydrodipicolinate-synthase
MSFGRVLTAMITPFDGEGNVNYALTEKLADYLVTHGSDTLVVCGTTGESPTLSWQEEYELFKVVQQAVAGRGKVVAGTGSNSTHEAIDATRKAASLGLDGSLQVCPYYNKPNQEGLYAHFRAIAAATELPVILYNIPGRTGVNLAPETVARLAAVDNIVAIKEASGSLDQVSEVRLRTPLDFVIYSGDDSLTLPMLAVGATGVVSIASHIAGEAIQRMIRAFEEGRTAEAVRTHLQLFPLFRGLFWDTNPIPVKLALSLRGWDVSALRLPLTTGSDSLRERLETLLRQLQLLD
>NC_022600.1|WP_023175712.1|4337017_4338031_-|aspartate-semialdehyde-dehydrogenase
MTDTYRVAVLGATGAVGTEMVHLLEQRRFPLASLKLLASERSVGRQIAFAGEAVPVEPLTPGAIKDIDIVLGATEADLSRQYARTIVEAGAVFIDNSSAFRLDPDVPLVVPEVNLADLKHHAGIVANPNCSTILLVVALWPLHRRHAIRRVVVSTYQAASGAGAAGMSELLRQSRQILADEEFTCEVFPHPIAFNLFPHDSAIGADHYCAEERKLIYETRRIFHDDTLRIAVTCVRVPVLRAHSEAVNIEFAEPFALEEALAALSAAPGVHLVEDWQRNHFPMPIEASGKDPVLVGRIRQDLSCDHALDLWLSGDQLRKGAALNAVQIAEALAGGGL
>NC_022600.1|WP_187293849.1|4338161_4341512_-|response-regulator
MSRSKTGKQTSIVRRLLITLGILLGIVLIVSGIGQLLIVSQIGDLKQSYRQSRELSIQLGSILEGMTNQETGIRGYVIARDEVFLRPFYEGRAEYLHSLESTRQLIVPLTTRFDDEAMRKQLLMRLDAVEQAAEDWYDYVRSNILEPVRQGQAESALDAVRNRQGKLRFDRVRSAVASLQQQNTILFQRIEAQIGERQGRIELLSFGLLAIAGVVGGTVAWRLTRELREPLAALEQTALALGEGNFAARVPAEALQGKDELAVLAGTFNQMAERLGRQNLALRERDILDGLRQLDLILVEEIELGRLGERLLAGLGELTDSQLGALYLVEDGQLVLQVGRGLDSPALRLQPGEGMIGLAASRREPVFVERPGSEEPLALNTPAGALPLRSLSAWPLISNQQLVGVLFLAGLDPLTPQARNLLGSVAGRLAIALLNSRSVRAIEETRARLAATFEQMSDGVAITDSTGDPLVINPAGRRILGLKPDEPIDSGWQKRIELLSAGGEKLTAEELPVQRAVRFGSTIRSDLMLRVAGMTPLLVSVSASPLKDERGVVYGVVTVFRDVTVEREREARLAEQARELEELNSTLKITNEELEMQRNELEAVNEEIEQQRLQIEEQNRELLEADRQKNAFLASMSHELRTPLNAILGFSQLLMRNSLLKDQPQLMLQLERIYQNGRIQLRLVNDILDLAKIKAGKIELQYQPVALEAFIREIYASLESLAVQKNLKVAIAVSPSLQAVRTDPQQLRTIVTNLLSNAFKYTERGEVSVRVRELPDRHFEIVVRDTGIGIAAEQQGKVFDEFSRLEGAAVRQAGTGLGLAICKRLVNLMGGQIELASVVGEGSTFTVRLPDGPPPAASRPPRTSPPKVLIIEDDLQVQQLIATRLAERPYRLLFAPDSIEGIQIARIEQPDAIVLDPALPSMDLWKVLFELRTDPATMSTPILLQSVVGEQGLAIPLGLADFLTRPVGQESLLAVLRSRRVQPEGEAILVVDDIADNREYLAACLRDEGYRVVLAASGPEALDYLENHVPQLVILDLMMPQMDGFEVLSRLRSLPGGKHLPVIILSAMDLTDEQRRTLLAQQTEQILKKGAQSIDELLALLDETLKRRLDAMAASE
>NC_022600.1|WP_023175714.1|4341544_4342360_-|chemotaxis-protein-CheR
MITLVSADSGRQDADFSDRDWECFVYWLAGISPVDLFAFKLHQLERRLAIRREVAGFERWSDYRQFLQKHPQNLERLLQSLTISVSSFFRDPVCWQALETDLKTGSAPLRAWSVGCAGGQELYSLAICLDRIGRLEGSHLLGSDCSKEAIDQAQKAEYLISRNEPLSSSLLPYMRWLDQGRFCLDERLRQTATFRCEDLFRRTIHGRWDLILCRNLLIYLNGTAQVRLLRRLSQSLPIGGILFIGRSEWIARPQSLGLHPVSRCIYRKVEI
>NC_022600.1|WP_023175715.1|4342533_4342911_+|hypothetical-protein
MSAPWWPFLVLVPAAGLYFYFKLTVKDLASGENWLALVKDGLASGSAFVLVGVTFFFAYREGLGHWLGLILVLWSLTYWASALISYQNLQTIRGGGRVDSPFKRRAQATTRTNRQQRRTGGRRRP
>NC_022600.1|WP_023175716.1|4342951_4343968_+|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MVTPLLGQDAEALRLWVESEGQPAYRAQQLHRWLYQRGLRSLMEVTDWPKPWREKLQDVPVGRSHLLRESIAPDGTIKFLLVAADNEAIETVGIPGPGRLTVCVSSQVGCPMACCFCATGKSGFARDLGVHEIVDQVLTVQERFEQRVSHVVFMGMGEPLLNLDAVVRSLTVLNRDIGIGQRQMTISTVGVPGRIAELATYKLQATLAVSLHAPNQELRAQLIPTARRYPLDQLIADCRNYVQSTGRRLSFEYTLLSGVNDELKHARQLAGLLRGFQAHVNLIPYNPIEGGEFARPDNERVQRFAQELARHKLVASVRRTRGLEESAACGQLRRQQVP
>NC_022600.1|WP_023175717.1|4343996_4344701_-|DUF2490-domain-containing-protein
MRWLWLTMVGVALAALPAQAQVQPGLVEDFQTWTRFGLRGRFAGTPHRWGVEVENRLRNGSREERQFLVRPFVTLGVSDRFSVNLGWAHFFTWPTQGNDIQVETRLFQDYIYTFPVERLSIGQRIRVEERWFEGASDVSLRVRYRLQFQHPLDAERRWLANLSDELFWNLNTPRNAPVGGYEQNRVIASIIHKLTPELSVEIGYQGNFNNRPAPRADQFDHDLLLYFTYDLAGR

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022600_6	6.1\|2987580\|26\|NC_022600\|CRISPRCasFinder	2987580-2987605	26	NC_022600.1	510798-510823	0	1.0
NC_022600_6	6.1\|2987580\|26\|NC_022600\|CRISPRCasFinder	2987580-2987605	26	NC_022600.1	3280570-3280595	0	1.0
NC_022600_6	6.1\|2987580\|26\|NC_022600\|CRISPRCasFinder	2987580-2987605	26	NC_022600.1	1167284-1167309	0	1.0
NC_022600_6	6.1\|2987580\|26\|NC_022600\|CRISPRCasFinder	2987580-2987605	26	NC_022600.1	1347656-1347681	0	1.0
NC_022600_6	6.1\|2987580\|26\|NC_022600\|CRISPRCasFinder	2987580-2987605	26	NC_022600.1	3999506-3999531	0	1.0
NC_022600_6	6.1\|2987580\|26\|NC_022600\|CRISPRCasFinder	2987580-2987605	26	NC_022600.1	2175847-2175872	1	0.962
NC_022600_6	6.1\|2987580\|26\|NC_022600\|CRISPRCasFinder	2987580-2987605	26	NC_022600.1	2968338-2968363	1	0.962

1. spacer 6.1|2987580|26|NC_022600|CRISPRCasFinder matches to position: 510798-510823, mismatch: 0, identity: 1.0

ctgccccccgctctcctcctcctgcc	CRISPR spacer
ctgccccccgctctcctcctcctgcc	Protospacer
**************************

2. spacer 6.1|2987580|26|NC_022600|CRISPRCasFinder matches to position: 3280570-3280595, mismatch: 0, identity: 1.0

ctgccccccgctctcctcctcctgcc	CRISPR spacer
ctgccccccgctctcctcctcctgcc	Protospacer
**************************

3. spacer 6.1|2987580|26|NC_022600|CRISPRCasFinder matches to position: 1167284-1167309, mismatch: 0, identity: 1.0

ctgccccccgctctcctcctcctgcc	CRISPR spacer
ctgccccccgctctcctcctcctgcc	Protospacer
**************************

4. spacer 6.1|2987580|26|NC_022600|CRISPRCasFinder matches to position: 1347656-1347681, mismatch: 0, identity: 1.0

ctgccccccgctctcctcctcctgcc	CRISPR spacer
ctgccccccgctctcctcctcctgcc	Protospacer
**************************

5. spacer 6.1|2987580|26|NC_022600|CRISPRCasFinder matches to position: 3999506-3999531, mismatch: 0, identity: 1.0

ctgccccccgctctcctcctcctgcc	CRISPR spacer
ctgccccccgctctcctcctcctgcc	Protospacer
**************************

6. spacer 6.1|2987580|26|NC_022600|CRISPRCasFinder matches to position: 2175847-2175872, mismatch: 1, identity: 0.962

ctgccccccgctctcctcctcctgcc	CRISPR spacer
ctgccccccactctcctcctcctgcc	Protospacer
*********.****************

7. spacer 6.1|2987580|26|NC_022600|CRISPRCasFinder matches to position: 2968338-2968363, mismatch: 1, identity: 0.962

ctgccccccgctctcctcctcctgcc	CRISPR spacer
ctgccccccactctcctcctcctgcc	Protospacer
*********.****************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022600_1	1.1\|1267742\|32\|NC_022600\|CRISPRCasFinder	1267742-1267773	32	NZ_CP022762	Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence	577649-577680	7	0.781
NC_022600_1	1.1\|1267742\|32\|NC_022600\|CRISPRCasFinder	1267742-1267773	32	NZ_CP014703	Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence	576764-576795	7	0.781
NC_022600_1	1.1\|1267742\|32\|NC_022600\|CRISPRCasFinder	1267742-1267773	32	NZ_CP022771	Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence	577637-577668	7	0.781
NC_022600_1	1.1\|1267742\|32\|NC_022600\|CRISPRCasFinder	1267742-1267773	32	NZ_CP022777	Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence	577656-577687	7	0.781
NC_022600_1	1.1\|1267742\|32\|NC_022600\|CRISPRCasFinder	1267742-1267773	32	NZ_CP022799	Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence	577634-577665	7	0.781
NC_022600_2	2.33\|2069251\|35\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2069251-2069285	35	MN812204	Flavobacterium phage vB_FspM_lotta8-2, complete genome	24984-25018	7	0.8
NC_022600_2	2.33\|2069251\|35\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2069251-2069285	35	NC_048829	Flavobacterium phage vB_FspM_lotta8-1, complete genome	25109-25143	7	0.8
NC_022600_1	1.1\|1267742\|32\|NC_022600\|CRISPRCasFinder	1267742-1267773	32	NC_002679	Mesorhizobium japonicum MAFF 303099 plasmid pMLa, complete sequence	250383-250414	8	0.75
NC_022600_1	1.1\|1267742\|32\|NC_022600\|CRISPRCasFinder	1267742-1267773	32	NC_015952	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI02, complete sequence	67751-67782	8	0.75
NC_022600_1	1.1\|1267742\|32\|NC_022600\|CRISPRCasFinder	1267742-1267773	32	NZ_HG938354	Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence	291704-291735	8	0.75
NC_022600_2	2.26\|2068747\|34\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2068747-2068780	34	NZ_CP040096	Pantoea sp. SO10 plasmid unnamed1, complete sequence	601679-601712	8	0.765
NC_022600_2	2.32\|2069180\|34\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2069180-2069213	34	NZ_CP013110	Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence	1590653-1590686	8	0.765
NC_022600_1	1.1\|1267742\|32\|NC_022600\|CRISPRCasFinder	1267742-1267773	32	NZ_LR134466	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 24, complete sequence	57854-57885	9	0.719
NC_022600_2	2.26\|2068747\|34\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2068747-2068780	34	NC_014841	Pantoea sp. At-9b plasmid pPAT9B04, complete sequence	310814-310847	9	0.735
NC_022600_2	2.26\|2068747\|34\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2068747-2068780	34	NZ_CP017105	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence	541367-541400	9	0.735
NC_022600_2	2.26\|2068747\|34\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2068747-2068780	34	NZ_CP017244	Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence	1612119-1612152	9	0.735
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MG944220	Mycobacterium phage Ruotula, complete genome	11970-12006	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MH371110	Mycobacterium phage Magnar, complete genome	11435-11471	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MH576959	Mycobacterium phage Pita2, complete genome	12192-12228	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MH576974	Mycobacterium phage Sibs6, complete genome	11987-12023	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MK359299	Mycobacterium phage Petp2012, complete genome	12660-12696	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MG920060	Mycobacterium phage Bob3, complete genome	11274-11310	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MG925351	Mycobacterium phage MPlant7149, complete genome	11288-11324	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MK820638	Mycobacterium phage HermioneGrange, complete genome	11434-11470	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	KT438500	Mycobacterium phage Pari, complete genome	11927-11963	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MN617845	Mycobacterium phage BaconJack, complete genome	11745-11781	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MT639654	Mycobacterium phage Jerm2, complete genome	11934-11970	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	JF937103	Mycobacterium virus Museum, complete genome	11776-11812	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MH576971	Mycobacterium phage Arlo, complete genome	11327-11363	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	KT818595	Mycobacterium phage Pepe, complete genome	12183-12219	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	KT259047	Mycobacterium phage Rufus, complete genome	11850-11886	9	0.757
NC_022600_4	4.11\|2601373\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601373-2601409	37	MH450130	Mycobacterium phage Rohr, complete genome	11967-12003	9	0.757
NC_022600_1	1.1\|1267742\|32\|NC_022600\|CRISPRCasFinder	1267742-1267773	32	NZ_CP022418	Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-3, complete sequence	105058-105089	10	0.688
NC_022600_2	2.26\|2068747\|34\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2068747-2068780	34	NC_023284	Streptomyces sp. F2 plasmid pFRL4, complete sequence	118998-119031	10	0.706
NC_022600_4	4.10\|2601302\|35\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601302-2601336	35	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	145123-145157	10	0.714
NC_022600_2	2.27\|2068818\|35\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2068818-2068852	35	CP027480	Pseudomonas koreensis strain P19E3 plasmid p3, complete sequence	98859-98893	11	0.686
NC_022600_4	4.15\|2601660\|37\|NC_022600\|CRISPRCasFinder,CRT,PILER-CR	2601660-2601696	37	NZ_CP048421	Sphingomonas insulae strain KCTC 12872 plasmid unnamed3, complete sequence	155794-155830	11	0.703

1. spacer 1.1|1267742|32|NC_022600|CRISPRCasFinder matches to NZ_CP022762 (Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.781

agggtgcgggccgccgcgccgcttatcgctcc	CRISPR spacer
agcgtgccggccgccgcgccgctggtgccgcc	Protospacer
** **** *************** .*  * **

2. spacer 1.1|1267742|32|NC_022600|CRISPRCasFinder matches to NZ_CP014703 (Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence) position: , mismatch: 7, identity: 0.781

agggtgcgggccgccgcgccgcttatcgctcc	CRISPR spacer
agcgtgccggccgccgcgccgctggtgccgcc	Protospacer
** **** *************** .*  * **

3. spacer 1.1|1267742|32|NC_022600|CRISPRCasFinder matches to NZ_CP022771 (Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.781

agggtgcgggccgccgcgccgcttatcgctcc	CRISPR spacer
agcgtgccggccgccgcgccgctggtgccgcc	Protospacer
** **** *************** .*  * **

4. spacer 1.1|1267742|32|NC_022600|CRISPRCasFinder matches to NZ_CP022777 (Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.781

agggtgcgggccgccgcgccgcttatcgctcc	CRISPR spacer
agcgtgccggccgccgcgccgctggtgccgcc	Protospacer
** **** *************** .*  * **

5. spacer 1.1|1267742|32|NC_022600|CRISPRCasFinder matches to NZ_CP022799 (Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.781

agggtgcgggccgccgcgccgcttatcgctcc	CRISPR spacer
agcgtgccggccgccgcgccgctggtgccgcc	Protospacer
** **** *************** .*  * **

6. spacer 2.33|2069251|35|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MN812204 (Flavobacterium phage vB_FspM_lotta8-2, complete genome) position: , mismatch: 7, identity: 0.8

---agaagctggtttgccgattgggatatttcgggaac	CRISPR spacer
atttcaagc---tttgccgattgggttacttcgggaac	Protospacer
     ****   ************* **.*********

7. spacer 2.33|2069251|35|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to NC_048829 (Flavobacterium phage vB_FspM_lotta8-1, complete genome) position: , mismatch: 7, identity: 0.8

---agaagctggtttgccgattgggatatttcgggaac	CRISPR spacer
atttcaagc---tttgccgattgggttacttcgggaac	Protospacer
     ****   ************* **.*********

8. spacer 1.1|1267742|32|NC_022600|CRISPRCasFinder matches to NC_002679 (Mesorhizobium japonicum MAFF 303099 plasmid pMLa, complete sequence) position: , mismatch: 8, identity: 0.75

agggtgcgggccgccgcgccgcttatcgctcc	CRISPR spacer
ctgatcgcggcggccgcgccgctgatcgctcc	Protospacer
  *.*   *** *********** ********

9. spacer 1.1|1267742|32|NC_022600|CRISPRCasFinder matches to NC_015952 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI02, complete sequence) position: , mismatch: 8, identity: 0.75

agggtgcgggccgccgcgccgcttatcgctcc	CRISPR spacer
agggagcgggccgccgcgcggctcgcctccgc	Protospacer
**** ************** ***...* *. *

10. spacer 1.1|1267742|32|NC_022600|CRISPRCasFinder matches to NZ_HG938354 (Neorhizobium galegae bv. orientalis str. HAMBI 540 plasmid pHAMBI540a, complete sequence) position: , mismatch: 8, identity: 0.75

agggtgcgggccgccgcgccgcttatcgctcc	CRISPR spacer
agggtgcgggcctctgcgccgctgccggccgc	Protospacer
************ *.********  . **. *

11. spacer 2.26|2068747|34|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP040096 (Pantoea sp. SO10 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.765

gcgctgccatcgctgccgagcgcaaagctcgcaa---	CRISPR spacer
ccgccgccatcgctgcccagcgcaa---tcggacaca	Protospacer
 ***.************ *******   *** *

12. spacer 2.32|2069180|34|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP013110 (Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence) position: , mismatch: 8, identity: 0.765

actgcttatcgcctgcggagcgcgtctcttgggc	CRISPR spacer
gtggctgcgcgcctgcggagcgcgtctgttcggc	Protospacer
.. ***   ****************** ** ***

13. spacer 1.1|1267742|32|NC_022600|CRISPRCasFinder matches to NZ_LR134466 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 24, complete sequence) position: , mismatch: 9, identity: 0.719

agggtgcgggccgccgcgccgcttatcgctcc	CRISPR spacer
ctgctgcgcgccgccgcgccgctgatccacgc	Protospacer
  * **** ************** ***  . *

14. spacer 2.26|2068747|34|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to NC_014841 (Pantoea sp. At-9b plasmid pPAT9B04, complete sequence) position: , mismatch: 9, identity: 0.735

gcgctgccatcgctgccgagcgcaaagctcgcaa	CRISPR spacer
aggctgccatcggtgccgagggcaaaacaggtca	Protospacer
. ********** ******* *****.*  *. *

15. spacer 2.26|2068747|34|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017105 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence) position: , mismatch: 9, identity: 0.735

gcgctgccatcgctgccgagcgcaaagctcgcaa	CRISPR spacer
ccggccgtatcggtgccgagcgcgaagctcgcca	Protospacer
 ** .  .**** **********.******** *

16. spacer 2.26|2068747|34|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017244 (Rhizobium etli 8C-3 plasmid pRsp8C3c, complete sequence) position: , mismatch: 9, identity: 0.735

gcgctgccatcgctgccgagcgcaaagctcgcaa	CRISPR spacer
ccggccgtatcggtgccgagcgcgaagctcgcca	Protospacer
 ** .  .**** **********.******** *

17. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MG944220 (Mycobacterium phage Ruotula, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

18. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MH371110 (Mycobacterium phage Magnar, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

19. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MH576959 (Mycobacterium phage Pita2, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

20. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MH576974 (Mycobacterium phage Sibs6, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

21. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MK359299 (Mycobacterium phage Petp2012, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

22. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MG920060 (Mycobacterium phage Bob3, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

23. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MG925351 (Mycobacterium phage MPlant7149, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

24. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MK820638 (Mycobacterium phage HermioneGrange, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

25. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to KT438500 (Mycobacterium phage Pari, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

26. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MN617845 (Mycobacterium phage BaconJack, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

27. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MT639654 (Mycobacterium phage Jerm2, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

28. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to JF937103 (Mycobacterium virus Museum, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

29. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MH576971 (Mycobacterium phage Arlo, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

30. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to KT818595 (Mycobacterium phage Pepe, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

31. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to KT259047 (Mycobacterium phage Rufus, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

32. spacer 4.11|2601373|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to MH450130 (Mycobacterium phage Rohr, complete genome) position: , mismatch: 9, identity: 0.757

atccgcttgtcctgcgcctcgacgagcgtagtcagct	CRISPR spacer
gctcgctcgtcctgcgcctcggcgagcgtatcccgat	Protospacer
...****.*************.******** .* * *

33. spacer 1.1|1267742|32|NC_022600|CRISPRCasFinder matches to NZ_CP022418 (Sulfitobacter pseudonitzschiae strain SMR1 plasmid pSMR1-3, complete sequence) position: , mismatch: 10, identity: 0.688

agggtgcgggccgccgcgccgcttatcgctcc	CRISPR spacer
gctttgcgggccgccgcgccgcgtttctttga	Protospacer
.   ****************** * ** .*

34. spacer 2.26|2068747|34|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to NC_023284 (Streptomyces sp. F2 plasmid pFRL4, complete sequence) position: , mismatch: 10, identity: 0.706

gcgctgccatcgctgccgagcgcaaagctcgcaa	CRISPR spacer
actctgccgtcgctgccgatcgcaaagggtgagg	Protospacer
.* *****.********** *******  .* ..

35. spacer 4.10|2601302|35|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 10, identity: 0.714

acattggccgcgccgctgtccgccggctcagcgct	CRISPR spacer
ccgctgtcggcgccgctgtccgccggctcgaccag	Protospacer
 *..** * ********************..*

36. spacer 2.27|2068818|35|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to CP027480 (Pseudomonas koreensis strain P19E3 plasmid p3, complete sequence) position: , mismatch: 11, identity: 0.686

cagcttgctcgacctgggcaatgcgctggtcgagg	CRISPR spacer
taatcggctcgacctgggtaattcgctggtctgtt	Protospacer
.*... ************.*** ******** .

37. spacer 4.15|2601660|37|NC_022600|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP048421 (Sphingomonas insulae strain KCTC 12872 plasmid unnamed3, complete sequence) position: , mismatch: 11, identity: 0.703

cagattgttctgctcgaaaccgaggagcaccttcggg	CRISPR spacer
gacgcggcgctgctcgaaaccgaggagcagctccgcc	Protospacer
 * .. *. ******************** **.**

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

409780 : 448626

Planktothrix_phage(22.22%)

tail,transposase,terminase,integrase,protease

attL 410096:410113|attR 434078:434095

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023171643.1\|409780_410206_+\|protease	Zn-dependent protease	NA	NA	NA	NA
410096:410113	attL	NA	NA	NA	NA
WP_041244230.1\|410257_411442_+	chorismate synthase	A0A291AU41	Pandoravirus	1.6e-39	34.2
WP_023171645.1\|411496_412357_+	dienelactone hydrolase family protein	NA	NA	NA	NA
WP_023171646.1\|412353_413442_-	sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC	G9BWD6	Planktothrix_phage	6.5e-27	36.4
WP_023171647.1\|413509_414016_+	hypothetical protein	NA	NA	NA	NA
WP_023171648.1\|414016_415270_+	bifunctional tetrahydrofolate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_023171649.1\|415496_416627_+\|integrase	tyrosine-type recombinase/integrase	G9BWC1	Planktothrix_phage	2.8e-73	41.5
WP_023171650.1\|417294_417573_+	hypothetical protein	NA	NA	NA	NA
WP_144080292.1\|417799_419935_+	AAA family ATPase	A0A1B1INT2	uncultured_Mediterranean_phage	2.4e-17	31.1
WP_023171652.1\|419906_420356_+	hypothetical protein	NA	NA	NA	NA
WP_023171654.1\|420352_420748_+	hypothetical protein	NA	NA	NA	NA
WP_023171655.1\|420744_420993_+	hypothetical protein	NA	NA	NA	NA
WP_023171657.1\|421302_421812_+	hypothetical protein	NA	NA	NA	NA
WP_023171658.1\|421808_423176_+\|terminase	phage terminase large subunit	M4SS86	Cyanophage	2.0e-86	42.6
WP_023171659.1\|423180_426441_+\|tail	phage tail tape measure protein	M4QFE1	Prochlorococcus_phage	9.3e-21	30.0
WP_023171660.1\|426474_427056_+	hypothetical protein	NA	NA	NA	NA
WP_023171662.1\|427414_427780_-	hypothetical protein	NA	NA	NA	NA
WP_041243658.1\|427776_428019_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_023171664.1\|428162_428579_+	SWIM zinc finger family protein	NA	NA	NA	NA
WP_023171665.1\|428591_428945_+	hypothetical protein	NA	NA	NA	NA
WP_023171666.1\|428941_429208_+	hypothetical protein	NA	NA	NA	NA
WP_023171667.1\|429263_429512_+	hypothetical protein	NA	NA	NA	NA
WP_023171668.1\|429643_430246_+	hypothetical protein	NA	NA	NA	NA
WP_144080293.1\|430891_431098_+	hypothetical protein	NA	NA	NA	NA
WP_144080294.1\|431259_431481_+	hypothetical protein	NA	NA	NA	NA
WP_023171669.1\|431521_434590_-	efflux RND transporter permease subunit	NA	NA	NA	NA
434078:434095	attR	NA	NA	NA	NA
WP_023171670.1\|434586_435855_-	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_051382605.1\|436023_436701_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_023171673.1\|436710_437838_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_023171674.1\|437847_438903_-	tetraprenyl-beta-curcumene synthase family protein	NA	NA	NA	NA
WP_023171675.1\|439034_439835_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_023171676.1\|439910_440528_-	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_023171678.1\|440812_440956_+	hypothetical protein	NA	NA	NA	NA
WP_023171679.1\|441034_442498_+	YdiU family protein	A0A075BSJ0	Microcystis_phage	1.5e-151	59.5
WP_023171680.1\|442481_442826_+	DUF4864 domain-containing protein	NA	NA	NA	NA
WP_023171681.1\|442822_443281_-	cupin domain-containing protein	NA	NA	NA	NA
WP_023171682.1\|443606_444854_+\|tail	tail fiber domain-containing protein	A0A2H4UUJ5	Bodo_saltans_virus	1.2e-16	40.9
WP_023171683.1\|444861_447186_-	TonB-dependent receptor	A0A0P0I887	Acinetobacter_phage	6.2e-11	35.3
WP_023171280.1\|447597_448626_+\|transposase	IS110 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

2884835 : 2939437

Bacillus_virus(14.29%)

plate,tail,transposase,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023171280.1\|2884835_2885864_+\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_023174195.1\|2886146_2886920_-	ABC transporter permease	NA	NA	NA	NA
WP_023174196.1\|2886919_2887765_-	ABC transporter permease	NA	NA	NA	NA
WP_023174197.1\|2887761_2888871_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.9e-27	38.6
WP_023174198.1\|2888867_2890244_-	protein phosphatase 2C domain-containing protein	NA	NA	NA	NA
WP_023174199.1\|2890248_2891220_-	FHA domain-containing protein	NA	NA	NA	NA
WP_023174200.1\|2891224_2893276_-	hypothetical protein	NA	NA	NA	NA
WP_023174201.1\|2893272_2895516_-	WD40 repeat domain-containing protein	NA	NA	NA	NA
WP_023174202.1\|2895583_2896207_-	hypothetical protein	NA	NA	NA	NA
WP_023174204.1\|2896400_2897618_-	DUF4159 domain-containing protein	NA	NA	NA	NA
WP_187293932.1\|2897614_2899117_-\|tail	phage tail protein	NA	NA	NA	NA
WP_023174206.1\|2899175_2901374_-\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_023174207.1\|2901380_2901803_-	GPW/gp25 family protein	M4SKQ1	Cyanophage	4.0e-09	35.2
WP_023174208.1\|2901887_2903444_-	alkaline phosphatase D family protein	NA	NA	NA	NA
WP_023174211.1\|2904310_2905684_-	B12-binding domain-containing radical SAM protein	NA	NA	NA	NA
WP_023174212.1\|2905769_2907140_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	NA	NA	NA	NA
WP_041243943.1\|2907300_2909238_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_023174215.1\|2909241_2910276_+	aromatic ring-hydroxylating dioxygenase subunit alpha	NA	NA	NA	NA
WP_023174216.1\|2910321_2911101_+	SAM-dependent chlorinase/fluorinase	NA	NA	NA	NA
WP_023174217.1\|2911097_2911541_-	RrF2 family transcriptional regulator	NA	NA	NA	NA
WP_023174219.1\|2911637_2912285_+	cytochrome b6	NA	NA	NA	NA
WP_023174220.1\|2912321_2912801_+	cytochrome b6-f complex subunit IV	NA	NA	NA	NA
WP_023174221.1\|2912993_2914832_+\|protease	ATP-dependent zinc metalloprotease FtsH	E5EQ50	Micromonas_sp._RCC1109_virus	3.4e-129	46.2
WP_023174222.1\|2914900_2916598_-	TolC family protein	NA	NA	NA	NA
WP_023174223.1\|2916862_2917267_+	hypothetical protein	NA	NA	NA	NA
WP_187293814.1\|2917304_2917961_-	SIMPL domain-containing protein	NA	NA	NA	NA
WP_023174225.1\|2918055_2918529_-	putative molybdenum carrier protein	NA	NA	NA	NA
WP_023174226.1\|2918528_2919527_-	hypothetical protein	NA	NA	NA	NA
WP_023174227.1\|2919523_2920612_-	2OG-Fe(II) oxygenase	NA	NA	NA	NA
WP_023174228.1\|2920625_2923517_-	protein kinase	A0A1C9C556	Heterosigma_akashiwo_virus	1.2e-19	30.6
WP_041244771.1\|2923520_2924084_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_023174230.1\|2924516_2925851_+	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_023174231.1\|2925969_2926668_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.6e-34	40.5
WP_023174232.1\|2926679_2926892_-	RNA chaperone Hfq	NA	NA	NA	NA
WP_023174233.1\|2926903_2928277_-	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	5.6e-36	27.8
WP_023174234.1\|2928316_2930401_-	polyphosphate kinase 1	NA	NA	NA	NA
WP_023174236.1\|2930588_2931719_+\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_023174237.1\|2932365_2932818_+	SRPBCC family protein	NA	NA	NA	NA
WP_023174238.1\|2932818_2933313_-	FKBP-type peptidyl-prolyl cis-trans isomerase	NA	NA	NA	NA
WP_023174239.1\|2933408_2933876_+	SRPBCC family protein	NA	NA	NA	NA
WP_023174241.1\|2933885_2934437_+	redoxin domain-containing protein	NA	NA	NA	NA
WP_023174242.1\|2934433_2934709_-	MoaD/ThiS family protein	NA	NA	NA	NA
WP_023174244.1\|2934753_2936046_-	threonine synthase	NA	NA	NA	NA
WP_023174245.1\|2936173_2936683_+	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_023174246.1\|2936971_2939437_+\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	5.2e-125	39.4

DBSCAN-SWA_3

3471131 : 3518352

Pandoravirus(50.0%)

tail,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023174823.1\|3471131_3471902_+\|protease	M48 family metalloprotease	NA	NA	NA	NA
WP_023174825.1\|3471898_3472390_+	DUF2127 domain-containing protein	NA	NA	NA	NA
WP_023174826.1\|3472465_3473071_+	hypothetical protein	NA	NA	NA	NA
WP_023174827.1\|3473122_3473407_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_071824824.1\|3474552_3475344_+	fatty acid desaturase	NA	NA	NA	NA
WP_041244896.1\|3475358_3476450_-	saccharopine dehydrogenase NADP-binding domain-containing protein	NA	NA	NA	NA
WP_023174831.1\|3476748_3477609_+	hypothetical protein	NA	NA	NA	NA
WP_023174832.1\|3477620_3478349_-	sulfite exporter TauE/SafE family protein	NA	NA	NA	NA
WP_023174833.1\|3478359_3478899_-	thioredoxin family protein	NA	NA	NA	NA
WP_081705281.1\|3479155_3480478_+	serine/threonine protein kinase	M1PCM5	Moumouvirus	7.4e-17	31.5
WP_023174835.1\|3480360_3481857_-	anthranilate synthase component I	S4VNU7	Pandoravirus	2.5e-37	37.9
WP_023174836.1\|3481911_3482181_+	hypothetical protein	NA	NA	NA	NA
WP_023174837.1\|3482248_3482887_-	hypothetical protein	NA	NA	NA	NA
WP_041244007.1\|3483081_3484182_-	magnesium chelatase ATPase subunit I	NA	NA	NA	NA
WP_023174840.1\|3484229_3485771_-\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_023174841.1\|3485862_3486987_+	geranylgeranyl reductase family protein	NA	NA	NA	NA
WP_023174842.1\|3487003_3487771_+	hypothetical protein	NA	NA	NA	NA
WP_023174843.1\|3487886_3488234_+	nucleotidyltransferase family protein	NA	NA	NA	NA
WP_023174844.1\|3488220_3488529_+	DUF86 domain-containing protein	NA	NA	NA	NA
WP_023174845.1\|3488631_3489171_-	HNH endonuclease	NA	NA	NA	NA
WP_023174846.1\|3489174_3489573_-	DUF393 domain-containing protein	NA	NA	NA	NA
WP_041244008.1\|3489706_3490381_+	DUF1995 family protein	NA	NA	NA	NA
WP_023174848.1\|3490377_3491295_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_023174849.1\|3491399_3491987_+	DUF4142 domain-containing protein	NA	NA	NA	NA
WP_023174850.1\|3492035_3492851_-	DUF4239 domain-containing protein	NA	NA	NA	NA
WP_023174851.1\|3493113_3496221_+	efflux RND transporter permease subunit	NA	NA	NA	NA
WP_023174852.1\|3496350_3498192_+	alkaline phosphatase family protein	NA	NA	NA	NA
WP_023174853.1\|3498195_3498831_-	Uma2 family endonuclease	NA	NA	NA	NA
WP_023174854.1\|3499018_3500044_+	sulfonate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_023174855.1\|3500057_3501155_+	FMNH2-dependent alkanesulfonate monooxygenase	NA	NA	NA	NA
WP_023174856.1\|3501187_3503812_+	TonB-dependent receptor	NA	NA	NA	NA
WP_023174857.1\|3504036_3504360_+	hypothetical protein	NA	NA	NA	NA
WP_023174858.1\|3504427_3505705_-	MFS transporter	NA	NA	NA	NA
WP_023174859.1\|3506008_3507121_-	sorbosone dehydrogenase family protein	NA	NA	NA	NA
WP_023174860.1\|3507148_3507643_-	type II 3-dehydroquinate dehydratase	NA	NA	NA	NA
WP_023174863.1\|3507780_3509058_-	competence/damage-inducible protein A	NA	NA	NA	NA
WP_023174864.1\|3509135_3509573_+	hypothetical protein	NA	NA	NA	NA
WP_041244009.1\|3509576_3510611_-	TIGR03032 family protein	NA	NA	NA	NA
WP_023174866.1\|3510721_3511855_+	hypothetical protein	NA	NA	NA	NA
WP_023174867.1\|3511856_3513035_-	LL-diaminopimelate aminotransferase	NA	NA	NA	NA
WP_081705382.1\|3513072_3513882_-	serine/threonine protein kinase	A0A0B5J6A8	Pandoravirus	2.0e-12	29.9
WP_187293940.1\|3514008_3514191_-	hypothetical protein	NA	NA	NA	NA
WP_023174871.1\|3514265_3514640_-	hypothetical protein	NA	NA	NA	NA
WP_041244904.1\|3514722_3515037_-	hypothetical protein	NA	NA	NA	NA
WP_023174873.1\|3515048_3515564_-\|tail	phage tail protein	NA	NA	NA	NA
WP_023174875.1\|3515581_3516076_-\|tail	phage tail protein	NA	NA	NA	NA
WP_023174876.1\|3516112_3516577_-\|tail	phage tail protein	NA	NA	NA	NA
WP_023174877.1\|3516678_3518352_-\|tail	phage tail sheath family protein	H6WFT7	Cyanophage	4.8e-21	30.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022600

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection