CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NC_022606	Carnobacterium inhibens subsp. gilichinskyi, complete sequence	1 crisprs	cas3,RT,DEDDh,DinG,csa3	0	3
NC_022601	Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR12, complete sequence	0 crisprs	csa3	0	0
NC_022602	Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR47, complete sequence	0 crisprs	NA	0	0
NC_022603	Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR64, complete sequence	2 crisprs	NA	2	0
NC_022607	Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR15, complete sequence	0 crisprs	csa3	0	0
NC_022608	Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR9, complete sequence	0 crisprs	NA	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022606_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022606_1

1509000-1509077

Orphan

Consensus_repeat	Method
CGACATTTTTGAAGCTCACTCTTTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022606_1

>merge|NC_022606|1|1509000-1509077|CRISPRCasFinder
CGACATTTTTGAAGCTCACTCTTTCGCGAATGTTCCCTTGACGTAATAGTGGCGATATTTTTGAAGCTCACTCTTTCG

>NC_022606|1|1|1509000-1509077|CRISPRCasFinder
CGACATTTTTGAAGCTCACTCTTTCG	CGAATGTTCCCTTGACGTAATAGTGG
CGATATTTTTGAAGCTCACTCTTTCG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022606.1\|WP_043945695.1\|1520576_1522823_-\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
NC_022606.1\|WP_023178513.1\|1515388_1516129_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|182555
NC_022606.1\|WP_023178497.1\|1507186_1507573_-\|hypothetical-protein	unknown	unknown	unknown
NC_022606.1\|WP_023178506.1\|1510940_1511996_-\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|237282
NC_022606.1\|WP_023178503.1\|1508508_1508904_+\|hypothetical-protein	unknown	unknown	unknown
NC_022606.1\|WP_023178483.1\|1502618_1503041_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|226134
NC_022606.1\|WP_023178491.1\|1505423_1506506_-\|LD-carboxypeptidase	unknown	unknown	gnl\|CDD\|132883
NC_022606.1\|WP_023178501.1\|1508159_1508417_+\|hypothetical-protein	unknown	unknown	unknown
NC_022606.1\|WP_023178499.1\|1507595_1507751_-\|hypothetical-protein	unknown	unknown	unknown
NC_022606.1\|WP_023178519.1\|1517728_1519750_-\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NC_022606.1\|WP_023178509.1\|1513472_1514927_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NC_022606.1\|WP_023178522.1\|1523047_1523698_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NC_022606.1\|WP_023178511.1\|1514928_1515234_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NC_022606.1\|WP_023178495.1\|1506898_1507090_-\|hypothetical-protein	unknown	unknown	unknown
NC_022606.1\|WP_023178504.1\|1509197_1510574_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NC_022606.1\|WP_023178489.1\|1504594_1505314_-\|16S-rRNA-pseudouridine(516)-synthase	unknown	unknown	gnl\|CDD\|211327
NC_022606.1\|WP_023178487.1\|1504195_1504477_-\|DUF503-domain-containing-protein	unknown	unknown	gnl\|CDD\|377364
NC_022606.1\|WP_023178517.1\|1516617_1517724_-\|CamS-family-sex-pheromone-protein	unknown	unknown	gnl\|CDD\|377863
NC_022606.1\|WP_023178507.1\|1512026_1513457_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NC_022606.1\|WP_023178485.1\|1503309_1504149_+\|glycosyltransferase-family-8-protein	unknown	unknown	gnl\|CDD\|133037

Protein	Function_ID	Function_description	E-value
NC_022606.1\|WP_043945695.1\|1520576_1522823_-\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_022606.1\|WP_023178513.1\|1515388_1516129_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|182555	PRK10566, PRK10566, esterase; Provisional.	1.42286e-43
NC_022606.1\|WP_023178485.1\|1503309_1504149_+\|glycosyltransferase-family-8-protein	gnl\|CDD\|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	2.94711e-83
NC_022606.1\|WP_023178506.1\|1510940_1511996_-\|diacylglycerol-kinase	gnl\|CDD\|237282	PRK13055, PRK13055, putative lipid kinase; Reviewed.	0
NC_022606.1\|WP_023178489.1\|1504594_1505314_-\|16S-rRNA-pseudouridine(516)-synthase	gnl\|CDD\|211327	cd02553, PseudoU_synth_RsuA, Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.	5.49213e-84
NC_022606.1\|WP_023178483.1\|1502618_1503041_-\|VOC-family-protein	gnl\|CDD\|226134	COG3607, COG3607, Predicted lactoylglutathione lyase [General function prediction only].	1.88694e-47
NC_022606.1\|WP_023178491.1\|1505423_1506506_-\|LD-carboxypeptidase	gnl\|CDD\|132883	cd07062, Peptidase_S66_mccF_like, Microcin C7 self-immunity protein determines resistance to exogenous microcin C7. Microcin C7 self-immunity protein (mccF): MccF, a homolog of the LD-carboxypeptidase family, mediates resistance against exogenously added microcin C7 (MccC7), a ribosomally-encoded peptide antibiotic that contains a phosphoramidate linkage to adenosine monophosphate at its C-terminus. The plasmid-encoded mccF gene is transcribed in the opposite direction to the other five genes (mccA-E) and is required for the full expression of immunity but not for production. The catalytic triad residues (Ser, His, Glu) of LD-carboxypeptidase are also conserved in MccF, strongly suggesting that MccF shares the hydrolytic activity with LD-carboxypeptidases. Substrates of MccF have not been deduced, but could likely be microcin C7 precursors. The possible role of MccF is to defend producer cells against exogenous microcin from re-entering after having been exported. It is suggested that MccF is involved in microcin degradation or sequestration in the periplasm.	9.13669e-119
NC_022606.1\|WP_023178511.1\|1514928_1515234_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	8.81921e-30
NC_022606.1\|WP_023178509.1\|1513472_1514927_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NC_022606.1\|WP_023178522.1\|1523047_1523698_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	3.62225e-19
NC_022606.1\|WP_023178519.1\|1517728_1519750_-\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NC_022606.1\|WP_023178504.1\|1509197_1510574_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	4.1985e-176
NC_022606.1\|WP_023178487.1\|1504195_1504477_-\|DUF503-domain-containing-protein	gnl\|CDD\|377364	pfam04456, DUF503, Protein of unknown function (DUF503). Family of hypothetical bacterial proteins.	5.17226e-29
NC_022606.1\|WP_023178517.1\|1516617_1517724_-\|CamS-family-sex-pheromone-protein	gnl\|CDD\|377863	pfam07537, CamS, CamS sex pheromone cAM373 precursor. This family includes CamS, from which Staphylococcus aureus sex pheromone staph-cAM373 is processed.	6.04273e-141
NC_022606.1\|WP_023178507.1\|1512026_1513457_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0

>NC_022606.1|WP_023178503.1|1508508_1508904_+|hypothetical-protein
MKKRQLLNPLLVLLFPAFTIVFIPMFINYALTFTARTYNIQAFWFISLSWVLVGFAMAMIAYRLTVYSDKSDTFTKWISIIWTVILIVLLAGFHIGYSYSIYATLHLYGTFFVELTTGFYLSLTAIVHIRK
>NC_022606.1|WP_023178501.1|1508159_1508417_+|hypothetical-protein
MKNYKRRTFFLILINSYFTYIFLSGSYESDVNPLIFIFAVATGLYDLKQNKEDYPDFYLFARCFLLFLFSVGLIIDLITFAKIIL
>NC_022606.1|WP_023178499.1|1507595_1507751_-|hypothetical-protein
MKKITKSTSYQLLSTIVFCMAIFAIVHQKIAIGYLLIFIGYCLLRKSDFEK
>NC_022606.1|WP_023178497.1|1507186_1507573_-|hypothetical-protein
MKKLLIIPFCLVILMGCGIKKDTNIQEIDPVSSIEPISDWPGEVTVVSEVSELTYAIFNSVSSTAKAEIYEDGDKLTISFTDTALLEETEDKSTPLYYKIEVDPEYQHEYLIVLVNGEDAVLNSLILQ
>NC_022606.1|WP_023178495.1|1506898_1507090_-|hypothetical-protein
MTIRKKKFLALFIWMVIIFAFDSLSNHYSFLNPLRPFGFPVYLMGVMFTKDYINKKELKEQKL
>NC_022606.1|WP_023178491.1|1505423_1506506_-|LD-carboxypeptidase
MIKPFALKNGDRVAIVSLSRGILGEETCAHQLELGEKRLESLGLKPVFMPNALKGLDYLSDHPEARAQDLKDAFQDPTIKGIIAAIGGDDTYRLLPYLLEDENFITNVQENPKLFTGFSDTTINHLMFYKLGMVSFYGPSFITDIAELANGLLPYTKEFLQDYLEGYEQREIRSSKLWYEERTDFSKQALGQDRMQHDETHGYEVLQGTGIVSGPLLGGCVESLYDILVGELYPDEAEICKKYQLFPSLNEWEGKIVFLETSEEKPAPDILKKMLETLKETGIFSVVNGLIIGKPQDEVYYEEYKTIYSEVIDDVELPILYNVNFGHAYPRCALPYGTKATIDLDEKMIFIDESPFQTVE
>NC_022606.1|WP_023178489.1|1504594_1505314_-|16S-rRNA-pseudouridine(516)-synthase
MRLDKLLFETGFGSRRTVKRLIKSKQVEVNGKTILVDNLNVDPELQEVKVAGERIHYQPHVYYMLHKPNGVVSAVTDDNNQTVIDLIDPSQRVAGLFPVGRLDKDTEGLLLLTNNGQLGYQLLIPKKEVTKSYEAIVNERVTSEDQAAFAKGIVFDGGIKCKPAKLTILSSNNNESRVLLEISEGKFHQVKKMFLSVGKKVTYLKRLSMGPLELDETLPVGSYRPLYLEELIALRPYFK
>NC_022606.1|WP_023178487.1|1504195_1504477_-|DUF503-domain-containing-protein
MVILGMKVSFLIYNSYSLKDKRNVLKSIIKKTHNKFNVSISEVGAHDTLNQGVLGIAVVSNNRKLCQQTLDLVLKEIEDNGEVEIHSIEREEL
>NC_022606.1|WP_023178485.1|1503309_1504149_+|glycosyltransferase-family-8-protein
MIDPEITIVSATDDGFVPHLATLFLSILKTKKDETKINFYVIDDNISLTSKDSLNRMINEYNASISYLQIDTVKFEDMVESDRIPTTAYFRIAIPNYFKHTDIKRVIYLDCDIIAKEDIEDIWNIDLGDNLLAAVEDAGFHARLDAMEIDAESNTYFNSGMMIIDIEKWRAEKISEQVLKFATENSDELRFHDQDALNAILHDRWLVLHPRWNAQAYIITKEKKHPTKIGNLEYTEARNEPALIHYSGHVKPWQSESDHPFRDEYLNVRAETPFPMEED
>NC_022606.1|WP_023178483.1|1502618_1503041_-|VOC-family-protein
MAVGVQSIFMNLPVKDLTKSIEFFKALGFDFDEQFKDDKGASLIITESIYVMLLTEEFFSSFTHQKITDTSMENEVITALQVESKDAVDELVNKAIENGAEDKTTKLSEEEEAMMYYRRFKDLDGHLWEVMYMDMSAMGA
>NC_022606.1|WP_023178504.1|1509197_1510574_-|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MKADKVVPVKKNEKHTVKIEDLTHEGMGVARIQGYSLFIENALPGEQVEVKIHKTGKSFGYAKVLNRLNSSEDRVVIQDENYTRVGITPLQHMRYPAQLNFKKQQVINSMQRIAKLPEVPVYDTIGMANPSGYRNKAQIPVRKINDKLTTGFFRKNSHEVIPMENFYIQDPKIDETIIAVRDIMREYGVKPYNENENTGNLRHIIVRRGYYTGEIMIVLVTRTAKLFPTSKIIPDILEAIPEVVSIVQNVNPKHTNVILGDDAIVLYGEDKYRDTLLGNTFEISHRSFYQVNPQQTEKLYQTVLDFAELTGEETVIDAYSGIGTIALTLAKNAKHVYGIEIIEPAVENAKANAELNNIENVTFEAGAAEEVMVQWSEEGRTADLLVVDPPRKGLEKEFTEAVIAMQPTKMVYVSCNPATLARDLALLTEGGYTVKKVQPVDLFPQTTHVESVALLVRN
>NC_022606.1|WP_023178506.1|1510940_1511996_-|diacylglycerol-kinase
MRARVIYNPTSGREIVKKHLVEIFQIYEEAGYETSAYATTPEPNSARNEAERAAKAGFELIVAAGGDGTINEVVNGIAGLEKRPKLAIIPAGTTNDYARALHIPRNNLVEAAKIIQKEQSFFMDVGEAVMGEDLSYFINIGGGGMLTELTYDVPSQLKSVFGYLAYFVKGAEMLPRMKPIPMHIEYDDGIFEGEATMFLVALTNSIGGFEQIAPDALLDDGKFTLIIVKTSNLADMMYLVAQVLNGGKHITNSKILYKKTSKIFARPGNTSKMMINLDGEYGGDAPVTFTNLHQHIEIIASTDDIQKAVDKKDENAENVEDAFIKEVEELTNTDINGDGGIHSSKKEAHEK
>NC_022606.1|WP_023178507.1|1512026_1513457_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MNFETVIGLEVHVELKTDSKMFSPAPAHFGAEPNTNTNVIDWGYPGVLPVINKGAIEFGMKAAMALNCEISQDTKFDRKNYFYPDNPKAYQISQFDQPIGHDGWIEIEVDGKKKKIRIERVHLEEDAGKNTHGTDGYSYVDLNRQGTPLIEIVSEADMRSPEEAYAYLEAIKQIVQYTGVSDVKMEEGSMRCDANISIRPIGQEKFGTKTELKNLNSFNFVRRGLAFEEKRQEKVLLSGGVIQQETRRYDEATGDTLLMRVKEGSSDYRYFPEPDLPNIVIDEAWIERVKATIPEMPKDRRIRYINELGLPEYDAMVLTATKEMSDFFEGTLANGADAKQASNWLMGEVSAYLNSEKLELHETKLTPENLSGMIKLIADGTISSKMAKKVFRELILNGGDAQGVVEANGWVQLSDPAKLLPIINDILDKNAQSIEDFKNGKDRAVGFLVGQIMKATKGQANPGIVNKLLNDELSKR
>NC_022606.1|WP_023178509.1|1513472_1514927_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MKIADYSVEELHELLVKKEVTAQEVVKAVFERINETEEKIGAFITLTEEEALEQARKVDEEGIDPTNILSGIPIGIKDNIVTEGTRTTAASKILEDFVPIYDATVTKKVKEANMISVGKLNMDEFAMGGSTETSYYKLTHNPWNLDKVPGGSSGGSAAAVAAGQIPVSLGTDTGGSIRQPAAFNGIVGMKPTYGRVSRFGLIAFGSSLDQIGPFTRTVKDNALVLNAISGHDVNDSMSYEGEVPDFASDIEAGVKGMKIGVPTEYLNEKGLEEGVKEAVLKAIETFKSLGATVEEVSLPHSKYGVPAYYIIASSEASSNLQRFDGVRYGYRSPEAKTLEEVFVKSRTEGFGMEVKRRIMLGTFSLSSGFYDAHFKKAGQTRTLIRQDFDNVFKEYDLILGPTTPTTAFGIGEQIDDPIAMYLSDILTVPVNLAGVPAISIPCGFSNDLPVGLQLIGKHFDEQTIYKAAYAFEQATDFHKEKPNL
>NC_022606.1|WP_023178511.1|1514928_1515234_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MAITEEDVKHVAKLAKLEISDKGIAHFTEQMDAIIDMVEHLDELDTENVPVMVHGLRTYNVMREDKAVQGTDRDLLFKNVKEEKDGLIKVPAIMDNGEAGA
>NC_022606.1|WP_023178513.1|1515388_1516129_+|alpha/beta-fold-hydrolase
MEITIRKRTLGTIPLLEVVPRKQRNDLLPLIIYYHGWQSSKELNLTQARYLAHQGFRVLLPDAMNHGARKQPVSKIPSLTFWQSIQSNLFEFGFIIDYFRKIGFVDDVIGVGGTSMGGITTCALLTHHPEIKAAACLMGSPKLLAYQERIVEHAERLNRYLPQDYYELLNWIPNYDLSLHPETLKGRPLFIWHGKQDQIVPYQHVADFAEEQKDLSNIHFTDEDEVHLVKTNTMREVTSFFVNELM
>NC_022606.1|WP_023178517.1|1516617_1517724_-|CamS-family-sex-pheromone-protein
MNKKAIALMAACAFLLSACQSDEPETKETESVGEETETTSQLSGDYYSAIITDGTYKTSLNRGVTLGLNSTVNLKAFETGLMELSQEHFSPDSYYFQEGQYITTETTNNWLNRVSEDNPDGLNPEDNGKVEPDERNPIYLNSLLEQDYMVQTDDGFKLGGISIGLAMNSVDYYKKVQFGAESETKISQDKLVEEGKKMADKIVQHLRETEGVGDIPIVVGIFEQSTKDNLAGGVYITQAQSDDGSTSLTDWETINQKKVIFPTSGESNELSSFENFKAEIESFFPNLSGVTAEALYTDDQIMNMKVSINTQFYGESEIIAFTQHVSEKASSYLLPNIPIEITIKSINGTEAFLAREAGETQFYTHVFD
>NC_022606.1|WP_023178519.1|1517728_1519750_-|NAD-dependent-DNA-ligase-LigA
MPTQDFESAKQRVFDLRTLLDKYSYEYYVKDNPSIPDSDYDKLYHELVALEEEFPDLVSNDSPTQRVGGTILPGFEKVVHEAPMLSLGNAFNEGDLLDFDRRIKKLTDQPFTYICELKIDGLAVSLKYENGKLVRAATRGDGSVGENVTQNVRTIKSVPLRLKQPYSIEVRGECYMPKDSFIKLNQEREENGEAIFANPRNAAAGGLRNLDPKQTAKRNLNTFLYTVGDFGELTAASQEDALNQLDGLGLRTNHDRRVFQTIEEVWQYTQEFQEKRSDLPYEIDGIVIKVNEFEVQEKVGFTVKAPRWAIAYKFPAEEAHTIIRDIEWSVGRTGVVTPTAIMDPVQLAGTTVQRASLHNEDLIHERDIRLLDTVVVHKAGDIIPEVTRVVLDERPSDSQPYEIPTHCPACDSELIHLEEEVALRCMNPKCPAQITEGLSHFVSRNAMNIDGLGIKVLLQMFEKEMVHDVADLYTLTFNQLVTLDKIKEKSANNLLTAIDASRSNSLERLLFGLGIRHVGAKAAKLIAERFETIEAVQQAEKEAIISIEGIGEIIAESVVAYFSLPEVTELIQELKSSQVNMTYLGKKKEEVATVDSYFNGKTVVLTGKLTHFTREEAKERIENLGGNVTGSVSKKTDFIVAGEEAGSKLTKAESLNIPIWDEVQLLETLEGEE
>NC_022606.1|WP_043945695.1|1520576_1522823_-|DNA-helicase-PcrA
MVLRDDLLNGMNPRQKDAVVCTQGPLLIMAGAGSGKTRVLTHRIAYLIEEKNVNPWNILAITFTNKAAKEMKERVTRLMKEGGSDVWVSTFHSMCVRILRRDIDRIGYTRAFTISDPSEQQTLMKRILKERNIDPKKYNPRAILGEISNAKNELQTPEDYRKEAASFFEKIVADCYDDYQRELRRNQSVDFDDLIMLTIRLFKESPETLEYYQNKFHYIHVDEYQDTNEAQYTLVNLLAERFKNLCVVGDADQSIYGWRGANMENILNFEKDYPDANTVLLEQNYRSTKLILQAANDVIGNNSNRKVKKLWTDNHDGEKITYYRGQSEGDESRYVISKIQEEMKESNYNYGDFAVLYRTNAQSRVIEDSLLKSNIPYKMVGGHKFYDRKEIRDVLAYLRLIANPEDNMSFERIVNVPKRGIGPGTIEKLRASSNQYEWSLLETALNVSITPISGKAANELEGFAFMMKDLRQMQEFVPVTELVQEVLKRSGYQKALESERTIESETRLENIQEFLTVTQQFEKENTEDKTLLTFLTDLALVSDLDNLEEEPQSEVTLMTLHAAKGLEFPIVFLIGLEEGIFPLSRSMMEEDQLEEERRLAYVGITRAEKKLYITNAYSRVLYGRTQSNSASRFINEITDEVLELGNQQNINTPFSRSTTSSMQRNQATRATSQVYKAPVTSKTSSGADKLGWNVGDKAVHKKWGVGTVVKVTGTANDLQLDIAFKEQGIKRLLAAFAPIEKQGAENDA
>NC_022606.1|WP_023178522.1|1523047_1523698_-|GntR-family-transcriptional-regulator
MSKPKKLVETVYQYSKDQILTKQWLPQTHITEIGLSKKLGISRTPIRQAFLRLEEEGYIAIEPNKGIRICENQISLQGFQERLEFMELVLIDYLHFLQIKEIQFDATTLEEIVDRLKKQAYVREFEVFSSIEFEYWKSLYRYAKNTYTTSLFMEMIRSINGQTNEEIKGFLQISQATKVKHFNNILSLLKSNNYALARKEVRILINQLSLIAIQGI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

303048 : 310626

Streptococcus_phage(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023176852.1\|303048_303930_+	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	7.7e-79	52.6
WP_023176853.1\|304070_304502_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_023176854.1\|304607_305567_+	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	7.1e-86	51.9
WP_023176855.1\|305764_307492_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	5.2e-196	57.9
WP_023176856.1\|307736_308624_+	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.7e-12	34.7
WP_023176857.1\|308620_309637_+	YvcK family protein	A1IMD5	Streptococcus_phage	1.2e-99	56.2
WP_023176858.1\|309669_310626_+	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	3.6e-50	36.4

DBSCAN-SWA_2

780755 : 788138

Lactococcus_phage(66.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023177450.1\|780755_783401_+\|tRNA	valine--tRNA ligase	A0A1V0S951	Catovirus	5.7e-162	42.5
WP_023177452.1\|783597_784902_+	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_023177453.1\|784920_785589_+	HAD family phosphatase	M1I5S4	Acanthocystis_turfacea_Chlorella_virus	4.0e-11	30.7
WP_169727079.1\|785668_786346_+	DNA repair protein RadC	NA	NA	NA	NA
WP_013710476.1\|786504_786705_+	cold-shock protein	Q9AZD3	Lactococcus_phage	9.0e-20	71.2
WP_013710476.1\|787068_787269_+	cold-shock protein	Q9AZD3	Lactococcus_phage	9.0e-20	71.2
WP_023177455.1\|787521_787722_+	cold-shock protein	Q9AZD3	Lactococcus_phage	4.1e-20	71.2
WP_023177456.1\|787937_788138_+	cold-shock protein	Q9AZD3	Lactococcus_phage	2.0e-19	69.7

DBSCAN-SWA_3

1182283 : 1191324

Erwinia_phage(16.67%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_043945637.1\|1182283_1183705_-\|protease	ATP-dependent protease ATPase subunit HslU	A0A191ZC11	Erwinia_phage	1.8e-45	28.1
WP_023178012.1\|1183720_1184260_-\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_023178013.1\|1184289_1185189_-	tyrosine recombinase XerC	A0A0K2CP59	Brevibacillus_phage	1.0e-33	30.9
WP_023178015.1\|1185408_1187487_-	type I DNA topoisomerase	A0A1V0SB35	Catovirus	2.4e-99	35.5
WP_023178016.1\|1187763_1188633_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	4.2e-29	42.2
WP_023178018.1\|1188775_1189288_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	6.7e-27	38.1
WP_144080632.1\|1189311_1191324_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	2.6e-58	28.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_022603

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_022603_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022603_1

23729-23805

Orphan

Consensus_repeat	Method
GACGAAGATAGTGATACCAGTATGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022603_1

>merge|NC_022603|1|23729-23805|CRISPRCasFinder
GACGAAGATAGTGATACCAGTATGAGCAATGAAAGTATGGAGATGGGACAGGACGAAGATAGTGATACTAGTATGAG

>NC_022603|1|1|23729-23805|CRISPRCasFinder
GACGAAGATAGTGATACCAGTATGAG	CAATGAAAGTATGGAGATGGGACAG
GACGAAGATAGTGATACTAGTATGAG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022603.1\|WP_023176465.1\|36500_37919_+\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NC_022603.1\|WP_023176461.1\|31382_32894_-\|SIR2-family-protein	unknown	unknown	gnl\|CDD\|238697
NC_022603.1\|WP_023176406.1\|25325_26840_-\|IS21-family-transposase	unknown	unknown	gnl\|CDD\|226950
NC_022603.1\|WP_023176462.1\|33011_33617_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NC_022603.1\|WP_007723259.1\|19727_19925_-\|hypothetical-protein	unknown	unknown	unknown
NC_022603.1\|WP_144080661.1\|29303_30785_-\|multicopper-oxidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|236810
NC_022603.1\|WP_023176463.1\|33935_34922_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NC_022603.1\|WP_023176407.1\|24610_25333_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|224401
NC_022603.1\|WP_007723239.1\|18454_18745_+\|hypothetical-protein	unknown	unknown	unknown
NC_022603.1\|WP_007723268.1\|22844_23078_+\|amino-acid-acetyltransferase	unknown	unknown	gnl\|CDD\|225993
NC_022603.1\|WP_023176464.1\|35140_36472_+\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NC_022603.1\|WP_023176458.1\|27178_28573_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NC_022603.1\|WP_023176455.1\|20494_21853_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|366703
NC_022603.1\|WP_007723246.1\|19058_19706_-\|TIGR01906-family-membrane-protein	unknown	unknown	gnl\|CDD\|377811
NC_022603.1\|WP_007723231.1\|15366_15630_+\|hypothetical-protein	unknown	unknown	unknown
NC_022603.1\|WP_023176459.1\|28556_29258_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NC_022603.1\|WP_007723234.1\|15725_15932_+\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219
NC_022603.1\|WP_023176453.1\|12858_15321_+\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NC_022603.1\|WP_023176454.1\|16070_18245_+\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319850
NC_022603.1\|WP_023176456.1\|21957_22842_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527

Protein	Function_ID	Function_description	E-value
NC_022603.1\|WP_023176465.1\|36500_37919_+\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	1.32267e-173
NC_022603.1\|WP_023176406.1\|25325_26840_-\|IS21-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	3.50199e-31
NC_022603.1\|WP_023176462.1\|33011_33617_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	1.10936e-45
NC_022603.1\|WP_144080661.1\|29303_30785_-\|multicopper-oxidase-domain-containing-protein	gnl\|CDD\|236810	PRK10965, PRK10965, multicopper oxidase; Provisional.	2.27877e-143
NC_022603.1\|WP_023176463.1\|33935_34922_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.73665e-21
NC_022603.1\|WP_023176407.1\|24610_25333_-\|ATP-binding-protein	gnl\|CDD\|224401	COG1484, DnaC, DNA replication protein [DNA replication, recombination, and repair].	4.95913e-56
NC_022603.1\|WP_023176461.1\|31382_32894_-\|SIR2-family-protein	gnl\|CDD\|238697	cd01406, SIR2-like, Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.	6.84953e-23
NC_022603.1\|WP_007723268.1\|22844_23078_+\|amino-acid-acetyltransferase	gnl\|CDD\|225993	COG3462, COG3462, Predicted membrane protein [Function unknown].	7.65856e-08
NC_022603.1\|WP_023176464.1\|35140_36472_+\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	5.1484e-111
NC_022603.1\|WP_023176458.1\|27178_28573_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.81067e-56
NC_022603.1\|WP_023176455.1\|20494_21853_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	4.85564e-42
NC_022603.1\|WP_007723246.1\|19058_19706_-\|TIGR01906-family-membrane-protein	gnl\|CDD\|377811	pfam07314, DUF1461, Protein of unknown function (DUF1461). This family contains a number of hypothetical bacterial proteins of unknown function approximately 200 residues long. These are possibly integral membrane proteins.	2.33311e-52
NC_022603.1\|WP_023176459.1\|28556_29258_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.54055e-90
NC_022603.1\|WP_007723234.1\|15725_15932_+\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	1.095e-11
NC_022603.1\|WP_023176453.1\|12858_15321_+\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_022603.1\|WP_023176454.1\|16070_18245_+\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319850	cd07552, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase. Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_022603.1\|WP_023176456.1\|21957_22842_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	2.96198e-119

>NC_022603.1|WP_007723268.1|22844_23078_+|amino-acid-acetyltransferase
MSECLNFFNRGGMGTMMFMGIFWILLLVVVVFLIGKLFFNQPNQSSNRETPLEILQKEYAKGNISEEDYLERKKHLQ
>NC_022603.1|WP_023176456.1|21957_22842_+|prolipoprotein-diacylglyceryl-transferase
MNGLLGKIDPIAISVGPFRVYWYGIIIAVAIFVAISLATREAKKRGLKEDTIIDIALWAIPIGFVGARLYYVLFEWDYYLQNPGEIIAIWNGGIAIYGGLIAGGLTVYWYTKKKGISLALLLDILAPSVLLAQSIGRWGNFMNQEAHGGPVSRQFLENLYLPEFIIEQMNINGTYYHPTFLYESLWSLLGFVIIIILRNRKQLLRQGEVALSYVLWYSTGRFFIEGMRTDSLWIGDFLRVSQALSLVLFIGSILIWYLRRQDYPSKPYYLEGMTDLRTSKNLESDEKFNKEKEE
>NC_022603.1|WP_023176455.1|20494_21853_+|peptidoglycan-DD-metalloendopeptidase-family-protein
MQKRLLAGVFVAALMINSSYLPLTVNAETTEQLEQKKQELETQSTQINSDIQEKEDQLGSLETEKETLTEDVKQLQLKIDGFVLQLQKEEKNLEESKWKIEKLQTEINSLKELILQREKKLKSQARAVQTDGNVSNLVDVVFSSGTFTDLVGRIGIVNQLVTANKEIVIVQENDKNLLEKNEKKAEEEKLTIETLKSGIEINKSNLVAQKSELDDKITKVAAAYDMTALEKTAFVKEQQAVAAQTSMLSDELEEKRERIIEEEKTKQAAAQKAAEDSAGEIMSEEFEEESLVVNKQDSSISSNNSSLAGSENPSSNEIPLEASNSDFIRPSNGYTTSPFGYRIHPITGERKLHGGIDFAGGGQIVAAKSGTVLVAGYHSSWGYYVKIDHGNGFQTLYAHMKAGSLLISPGQLVSQGQQIGTMGTTGASTGVHLHFEVYDNNTRVDPAPYLAL
>NC_022603.1|WP_007723259.1|19727_19925_-|hypothetical-protein
METILFFIIMIVGHGLMMFMMPGMHGGHGKKHNHGEKSSDDVELLKTENEELKEELHAVKSKLNR
>NC_022603.1|WP_007723246.1|19058_19706_-|TIGR01906-family-membrane-protein
MKSTVIYLLGFFCLFFFILSVSIAITINFTPLYTFDITYLNMADEIGMTKEVILKNYGVLINYLNFPWITELKMSDFPSSEKGLFHFFEVKKLFLLDYVTLVISGIGSILFLNYLKIKKGMWKLVRFFQWGSIIPPLLIVTLFINFDTLFVLFHKIFFNNDAWLFNPSTDPIILALPEAFFMHSFILAFGVIEFLFIIGYFISKKQWVKYEKKTP
>NC_022603.1|WP_007723239.1|18454_18745_+|hypothetical-protein
MTISIKVDEAVQEWMKKKGRTIITVSLRATRTCCVGAEDVDISYKNPQNNNYMLTQHNGLFIYLDKGLPLRKNELHLSMMGKSIFSSIHIEGLMVQ
>NC_022603.1|WP_023176454.1|16070_18245_+|cadmium-translocating-P-type-ATPase
MNDKKGKQPDHEHIDHSKMDHSKMDHSKMDHSKMDHSKMDHSKMDHSKMDHSKMDHSKMDHSKMAHDDHEGHAGNSGHEHHHHGSFKAIFLKSLPLGIVVMLLTPMMGISLPFQISFLYSDILAAVLSTILIIYGGKPFYMGAIDEFKQKDPGMMSLITLGIGVSYLYSVYAVIARYVTGEHMMDFFFEFASLLLIMLLGHWIEMKALGEAGNAQKSLAELVPKDAYVVLEDDAVESRPVSQLQVGDVIRVQAGENIPADGVIQRGQSRVNEALLTGESKPIEKNAGDQVIGGSTNQEGVLYIEVQETGDKSFISQVQTLVAQAQSQPSRAENLAKKVASSLFYVAIAVALIAFIVWLFITDVQTAIIFTVTTLVIACPHALGLAIPLVVSRSTSLGASHGLLVKDREALELATKADVMILDKTGTLTSGEFKVLNAESLSKDYSKEEVLALMSGIEGGSSHPIAQSIVGFAEKQKVKPINFDSINVVSGAGVEGEANGRRYELISQKAFGQKVDFEIPKGSTVSLLVEEGEAIGAVALGDELKSTSKELMEVLKARGIKPIMATGDNEKAAQGVAEELGIDYKANQSPQDKYDLVESLKKEGKTVIMVGDGVNDSPSLALADVGVAIGAGTQVALDSADVVLVRSDPGDIESFIELANKTTRKMKQNLIWGAGYNFIAIPIAAGILAPIGITLAPAFGAVLMSISTVIVAINAMTLRLEKKAV
>NC_022603.1|WP_007723234.1|15725_15932_+|heavy-metal-associated-domain-containing-protein
MKREVLVEGMKCEGCANTVQERFEAIEGVESVAIDLVNKKAVLESQSDIDKDKLVSALSDTKYSVING
>NC_022603.1|WP_007723231.1|15366_15630_+|hypothetical-protein
MKTGLIIEGIECEKCSDTIEKKIISKSTVEKVFNSLHKKIVFVHRQKSSSQLDFLTSLSDTPYLLGRVIESIDCHCCKEIRYNFQLG
>NC_022603.1|WP_023176453.1|12858_15321_+|copper-translocating-P-type-ATPase
MENKVFSIEGMTCASCAQTIEKATSKLPGVKAANVNLATEKMTIQFDELSLTEADIQKAVTDAGYAAKPNTLQKTFNIEGMTCSSCAQTIEKATQKLAGVNNSAVNLATEKMTVQYDPTVLNVSDITKVVTDAGYEAHEEVDSAAAVDLDREKKQQHIKEMWHRFLMSAIFTLPLLYIAMGHMLGLSLPEIVDPMMSPITFSLTQLILTLPVMYYGRSFFTVGFKTLFKGHPNMDSLVALGTSAAFVYSLFGTYMIYVGDISFTMVLYYESAAVILTLITLGKYFEAVSKGKTSEAIKKLMGLAPKTARVLRNDQEMEIAIDEVQVEDIIVVRPGEKLPVDGIVMEGNTSIDESMLTGESMPVEKKPSDNVIGASINKNGSFQYKATKVGKDTALSQIIKLVEDAQGSKAPIAKLADQISGIFVPIVIVLAVLAGLAWFFLGQESWIFALTITISVLVIACPCALGLATPTAIMVGTGKGAENGVLIKSGGALETTHKIGTIIFDKTGTITEGKPKVTDIVTTNGLSETDLLILAASAEKGSEHPLGEAIMNGAKERNLALIKTESFKAIPGLGIEVIINGQHLLLGNKKLMTESRISLEKLAAASDKLADQGKTPMYIAKDGNIAGIIAVADTVKENSLKAIEKLHRMGIEVAMITGDNKRTAEAIAKQVGIDRVMSEVLPEDKANEVKKLQAEGKKVAMVGDGINDAPALAQADTGIAIGSGTDVAMESADIVLMRSDLMDVPTAVELSKATIKNIKENLFWAFAYNILGIPVAMGLLYLFGGPLLSPIIAAAAMSFSSVSVLINALRLKRFKPSSVK
>NC_022603.1|WP_023176407.1|24610_25333_-|ATP-binding-protein
MHDDILNYAKRLKLSWIPQHYQEVEAQSQQEFLLKLVEAEVTQREEKKLNQLLKQSTLPTVNGETFIWNDIQLPSGMTKDFLLQGDFLEHKTNLIFYGGVGTGKTFLSTLIGLTIIRTQAKKVKFYTVASLVNALLEANNNGNLGKLMKQLSKLDLLILDELGYIPLHKQGGELLFQVISMCYETRSIIITTNLQFGQWNHVFGDQILTEAVVDRLIHHSHLLIFNGESHRYKQSILNSK
>NC_022603.1|WP_023176406.1|25325_26840_-|IS21-family-transposase
MLTVTEINYIREQVNLKDETYATIGRKMGIDARTIKKYADMEDFNLPKPHKQTRTARVMDSVKPVIDKWLIEDFKKKKKYRRTAKRIHQLLLEQYEFTGSDRTIRDYVSKRKKELLNTGQSSAIPLTAKPGMAQIDFGEAPFYYKNTYTTLSYLVLSFPYSNTFWFQVLEAQNKEAFLEGMKRIFHHMGGVPKAIRFDNLSPAVKKIRPHGKRDLTEEFERFTAHYGFQLEFCNPARGNEKGHVEAMVKYVRNNFLLPEVHTHDLRSLNQECWVLAENDRKRIHYQKQLPISELYSADKEAFLLLPEKEFDCVRYEEVKADKYGYVHFDTNLYSSSPRFALEKVLLKISYEHITVFSLDYKEIVQHNRLYGYKEKSMDWQPYLSLVSKRPTALKYTSFYDQLPDAWQSYFSQCTVEEKKESLQLLSTILKDNHMEIAIQALLQASENGHPSAESIKQIFYQLVNGRGVRAIAQLPQHTPSMPTITRGLGQYDKLFKPMEDENHA
>NC_022603.1|WP_023176458.1|27178_28573_-|HAMP-domain-containing-histidine-kinase
MNRTIKWQFIFSFVSISFIIIGAFSIMTLSLMDNHFAKYVAERQESEIGEYTTSLERIYEENEGWPNTADFESIGLESLHNLIILKVYDNEKNLLWDPASSDELGNKQKMQDNASYMDKIMGEMEHDYVEKTVPLFNGEQKIGEALISYMGPTAYSEHDALFIADMKNNLIIVAIVALILSIFFAALVAKKISGPIVRVKDFTREIAKGDYTSLSPEKTDIKELDELISSVNALSVQLENQQDIRNQLSSDIAHEIRTPLTTLKGSLEAMIDGIWEITDDRLQSCYDEVNRITRLIGSIDKINEIESHQDSLNKTSFDLYALAENISSNFEALFVKKNIYYALNGDPLFITADKDKISQVITNLLSNAVKFTPPEGIITLKISNEKNQALLTIADTGEGIHPKEINRIFERFYMSDLSRNSFLGGQGIGLSIVKSIIKAHHGNITVKSDYGKGSTFTVILPVKR
>NC_022603.1|WP_023176459.1|28556_29258_-|response-regulator-transcription-factor
MKILIVDDEPKILDIVEAYLTIKRFQVFRASNGTEAMEKFELVQPNLIVLDLMLPDISGTVICQKIRKTSDVPIIMLTAKSTENDILNGLQIGADDYIVKPFSPKELVARVETVLRRSDSSVVTETKWSFDKGNLVIYPENKQVFKNQKEVILTPTEFELLTLLASYPKKIFSREQLLENVKGLEFDVLDRIIDSHIKNLRQKIEDNTRQPYFILTVYGMGYRFGGKKDESYN
>NC_022603.1|WP_144080661.1|29303_30785_-|multicopper-oxidase-domain-containing-protein
MILLIVVSITLILIYNKTNFSLNDDNEEQIGMFNNETNSMMGNGQMESNNSIDIINNSQVQNKLKLPQLLESDQETSTDVFYTITTQSGTTAFKDGSLTETYGYNGSYLGPIIRIHKGQNVHLTTINKLKENTSFHWHGLKIPSNVDGGPHSPIKPNGTATVDFTVMQEAATLWFHPHPEGRTGEQVYNGLAGLIYVEDENSDSLDLPKDYGMNDFPIIVQDRFFDEDNQFNYQDIRNVDGTQGDTLLVNGTINPYIEVKNEQIRLRLVNGSNARNYQFNLSSKEKFYQIASDGGFLNEPVQMDTLQLVPGERAEIVVDLSDYKNGTIVQLMDGNAEVLSIKVVEEINSEVGSLPKTLNAISNDFDKVSVPDKKITFSGMGNMVAINGKQFDMDRMDLQAKTGTTEIWEINNLNDMMGGMIHPFHLHGVQFKVLDRNGKIPPANEQGWKDTIALYPGEKVQIEVEFSKKGIFMYHCHILEHEDNGMMGQIIVE
>NC_022603.1|WP_023176461.1|31382_32894_-|SIR2-family-protein
MNINEFISSFKNHPVLFIGTGFSLRYLENSYSWDNLLKKVSINLFETGEEYYNIKSRCEENGKYNYEKIATILEAQFNDFLEKNRNGKFKYINDIFFENMENDLNISRFKIYISELLNELNYKDNMHDELVQLKKVKKNIGSIITTNYDKLIEDIFDFIPLVGNDILLSNPYGAVYKIHGSISEPRNIIITVDDYLEFSKSYELIRAQLLSLFIHNPIIFLGYSISDKNIKDILKTIFSYVRPNTEQAKKIRDNFLLVEYEKDSTNLQVIEHDIDIEDFSTLRINKFKTDNYLELYKGLSKLQLPVSAMDIRKVQNVMKEITSGGEIEVKITEDIDSMNNSDKILVIGSSKSVSYDFMNAPELMDKYFNIIEEENAQILQPIDKIRIQSNQYFPMFGFEKINPSINSAEKLKEQQVIKINEELERIDIGEDTFYDSIDDILKCDQLGYVKMMRIIFWSVYHNKISIDNLEEYLKIYNNKDKTSYRKLLCLYDWKKHSVYVHCS
>NC_022603.1|WP_023176462.1|33011_33617_-|recombinase-family-protein
MRIAYARVSTDKQELYRQLDALEKVGYDKLIQEKFTGTQKKRAGLDSLFNTVRLGDTVIIESISRLGRKTLDILSTVEELKDQGVEVISLKENLDTSTPTGQAMFQMMAVIAQLERDLTVQRVNEGLASAKARGVTLGRPTMDKQKVQDALRLYDSGHYSVKDIIRITGISQGSLYRKIKERESKKIIAQIDEITELKKNI
>NC_022603.1|WP_023176463.1|33935_34922_-|helix-turn-helix-transcriptional-regulator
MKSSELAEYLESQEHIQEWINIKNVLPTLLKGNFNGENVYEFNYVLDTNKKIIDSNIGVTQQPYDSIIPYHTHNYVEIIYVYNGNCSVVIEDKIFQLHQGELIFIDKNTIHKVKQINKNDIVINFALKKDYFSPSFLSRLSNHSIVSNFLIKSLVNQQSANSYLLFRQSRDVDIEMIMSNILCEYYSKQIYTHEIIESYLIILFSILIRSNTISNQPSGTKRNDTSIISFLNYIEENYQNCNLKKIADTFGFHPNYISYLLKTYTGKTFSELLKLQRVHQATILLTNTNLSISEISEEVGYSSVSFFYKKFAEVYKISPKNYRNKFSL
>NC_022603.1|WP_023176464.1|35140_36472_+|PTS-sugar-transporter-subunit-IIC
MDRFLSFMESKFIPVATKISSNRVIQAVSRGSISLMPIIIVGAIFSLIGSINILAYQEFLINTGLIQFLDFIPSVTIDAIGLYMVFFVGYQGAKNFGKADMATSAGILSLVSFLVLIPLTTVMEEGAFQPLVTLNMDYIGSRGAFTAILTGLIVSKIHQIIIDKNWTLKMGEGVPPQVSNSFTDIIPSFLILTIFALIRWLFSVTPYESATGFIYEMLQTPLQSLTSSLPAFIILIFVSQLLWFFGIHGSYTILPILMPIWIGYIQENMAAYQAGQEIPHLFNIALYDLTTIGGAGATLGFVIVMAIFAKSQQYKSFSKLVLVPGIFNINEPLIFGLPIILNPFVFIPFVFTPIIILILGYVAILLGIMPAPIGLFIPASTPVIFSGIIQGSWKIAVFQVFSVLLSIGIYYPFFKLMDKQALEREQIVAETKTDNVTTDNVIN
>NC_022603.1|WP_023176465.1|36500_37919_+|glycoside-hydrolase-family-1-protein
MTNVKFPTDFLWGVSSSAFQIEGASTEDGKGLSTVDTRKVKEGIADTAIASDHYHHWKEDISLLAEMGVKTYRFSISWTRIFPSGEGEVNQKGLQFYDNLIDELLAYNIEPLVTMYHFDLPQNLVDKYQGWLSRETIDCYEKYAEVLFTHYGDRVKNWISINEELMVMYSQDFNGIRNLDEKQYKKAVFQMMYHMSLAEKKAFKLCHELVTDGKIGPANAFQNIYPATSDPLDVEAAMNAEEFLSYMLLDLSVKGKFPENTLRYLQKENLAPETLPEDEEILKNNKPDYICFNYYASLCAEVYTGLADDHMPPFFRSNMYRIVPNQTKSLSEWMVFGIDPVGMRISMRKLYNRYELPLMITENGYADSEELSDTFEINDEKRIGYLQLHLLECSKAIDEGIPLLGYSAWSFLDSLSGREGFSKRYGLVYVNRTDDDTKDLKRYKKKSFYWYQNAIKQNEFIVDEGKKNYDNK

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Crispr_ID: NC_022603_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022603_2

47116-47311

Orphan

Consensus_repeat	Method
TGTAGACGTATCTACAAATCTACAAATCTACATGTAGACGTATCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022603_2

>merge|NC_022603|2|47116-47311|CRISPRCasFinder
CGTTATTTAAAAAACACGTCTACAAATCTACATGTAGACGTATCTACAAATCTACAAATCTACATGTAGACGTATCTACAAATCTACAAATCTACATGTAGACGTATCTACTAACAAGATCCCTTTTAGGACAACGGTTTCAATACTTTTGTAGACGTATCTACAAATCTACAAATCTACATGTAGACGTATCTAC

>NC_022603|2|2|47116-47311|CRISPRCasFinder
CGTTATTTAAAAAACACGTCTACAAATCTACATGTAGACGTATCTAC	AAATCTACAAATCTACATGTAGACGTATCTACAAATCTACAAATCTACATGTAGACGTATCTACTAACAAGATCCCTTTTAGGACAACGGTTTCAATACTTT
TGTAGACGTATCTACAAATCTACAAATCTACATGTAGACGTATCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022603.1\|WP_052326534.1\|49898_50141_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NC_022603.1\|WP_023176471.1\|43294_44596_-\|M20-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349880
NC_022603.1\|WP_035020774.1\|52900_53239_+\|hypothetical-protein	unknown	unknown	unknown
NC_022603.1\|WP_023176465.1\|36500_37919_+\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NC_022603.1\|WP_023176482.1\|54777_56640_+\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319774
NC_022603.1\|WP_023176466.1\|37905_39597_+\|beta-N-acetylglucosaminidase	unknown	unknown	gnl\|CDD\|366376
NC_022603.1\|WP_023176474.1\|46208_47033_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379293
NC_022603.1\|WP_023176469.1\|41917_42682_+\|ChbG/HpnK-family-deacetylase	unknown	unknown	gnl\|CDD\|212116
NC_022603.1\|WP_023176483.1\|57024_57576_+\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271192
NC_022603.1\|WP_023176479.1\|51208_51781_+\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|153102
NC_022603.1\|WP_023176476.1\|48918_49668_+\|hypothetical-protein	unknown	unknown	unknown
NC_022603.1\|WP_023176467.1\|39589_40252_+\|beta-phosphoglucomutase	unknown	unknown	gnl\|CDD\|213672
NC_022603.1\|WP_023176473.1\|45771_46140_-\|hypothetical-protein	unknown	unknown	unknown
NC_022603.1\|WP_144080658.1\|42888_43068_+\|hypothetical-protein	unknown	unknown	unknown
NC_022603.1\|WP_023176480.1\|52054_52672_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NC_022603.1\|WP_003109035.1\|53223_54078_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NC_022603.1\|WP_023176468.1\|40577_41864_+\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NC_022603.1\|WP_043946074.1\|50166_50532_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|377579
NC_022603.1\|WP_003125439.1\|54224_54458_+\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NC_022603.1\|WP_023176472.1\|44938_45664_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718

Protein	Function_ID	Function_description	E-value
NC_022603.1\|WP_052326534.1\|49898_50141_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.77296e-09
NC_022603.1\|WP_023176471.1\|43294_44596_-\|M20-family-metallo-hydrolase	gnl\|CDD\|349880	cd03884, M20_bAS, M20 Peptidase beta-alanine synthase, an amidohydrolase. Peptidase M20 family, beta-alanine synthase (bAS; N-carbamoyl-beta-alanine amidohydrolase and beta-ureidopropionase; EC 3.5.1.6) subfamily. bAS is an amidohydrolase and is the final enzyme in the pyrimidine catabolic pathway, which is involved in the regulation of the cellular pyrimidine pool. bAS catalyzes the irreversible hydrolysis of the N-carbamylated beta-amino acids to beta-alanine or aminoisobutyrate with the release of carbon dioxide and ammonia. Also included in this subfamily is allantoate amidohydrolase (allantoate deiminase), which catalyzes the conversion of allantoate to (S)-ureidoglycolate, one of the crucial alternate steps in purine metabolism. It is possible that these two enzymes arose from the same ancestral peptidase that evolved into two structurally related enzymes with distinct catalytic properties and biochemical roles within the cell. Downstream enzyme (S)-ureidoglycolate amidohydrolase (UAH) is homologous in structure and sequence with AAH and catalyzes the conversion of (S)-ureidoglycolate into glyoxylate, releasing two molecules of ammonia as by-products. Yeast requires beta-alanine as a precursor of pantothenate and coenzyme A biosynthesis, but generates it mostly via degradation of spermine. Disorders in pyrimidine degradation and beta-alanine metabolism caused by beta-ureidopropionase deficiency (UPB1 gene) in humans are normally associated with neurological disorders.	0
NC_022603.1\|WP_023176483.1\|57024_57576_+\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271192	cd01192, INT_C_like_3, Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain. Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	4.86958e-49
NC_022603.1\|WP_023176465.1\|36500_37919_+\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	1.32267e-173
NC_022603.1\|WP_023176482.1\|54777_56640_+\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|319774	cd02079, P-type_ATPase_HM, P-type heavy metal-transporting ATPase. Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_022603.1\|WP_023176466.1\|37905_39597_+\|beta-N-acetylglucosaminidase	gnl\|CDD\|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	2.57776e-56
NC_022603.1\|WP_023176474.1\|46208_47033_-\|AAA-family-ATPase	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	4.25907e-48
NC_022603.1\|WP_023176469.1\|41917_42682_+\|ChbG/HpnK-family-deacetylase	gnl\|CDD\|212116	cd10805, YdjC_like_1, uncharacterized YdjC-like family proteins from bacteria. The subfamily contains many hypothetical proteins, and belongs to the YdjC-like family of uncharacterized proteins from bacteria. The YdjC-family is represented by an uncharacterised protein YdjC (also known as ChbG) encoded by the chb (N,N'-diacetylchitobiose, also called [GlcNAc]2) or cel operon in Escherichia coli, which encodes enzymes involved in growth on an N,N'-diacetylchitobiose carbon source. The molecular function of this subfamily is unclear.	4.48563e-104
NC_022603.1\|WP_023176479.1\|51208_51781_+\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|153102	cd01043, DPS, DPS protein, ferritin-like diiron-binding domain. DPS (DNA Protecting protein under Starved conditions) domain is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. Some DPS proteins nonspecifically bind DNA, protecting it from cleavage caused by reactive oxygen species such as the hydroxyl radicals produced during oxidation of Fe(II) by hydrogen peroxide. These proteins assemble into dodecameric structures, some form DPS-DNA co-crystalline complexes, and possess iron and H2O2 detoxification capabilities. Expression of DPS is induced by oxidative or nutritional stress, including metal ion starvation. Members of the DPS family are homopolymers formed by 12 four-helix bundle subunits that assemble with 23 symmetry into a hollow shell. The DPS ferroxidase site is unusual in that it is not located in a four-helix bundle as in ferritin, but is shared by 2-fold symmetry-related subunits providing the iron ligands. Many DPS sequences (e.g., E. coli) display an N-terminal extension of variable length that contains two or three positively charged lysine residues that extends into the solvent and is thought to play an important role in the stabilization of the complex with DNA. DPS Listeria Flp, Bacillus anthracis Dlp-1 and Dlp-2, and Helicobacter pylori HP-NAP which lack the N-terminal extension, do not bind DNA. DPS proteins from Helicobacter pylori, Treponema pallidum, and Borrelia burgdorferi are highly immunogenic.	6.68192e-44
NC_022603.1\|WP_023176467.1\|39589_40252_+\|beta-phosphoglucomutase	gnl\|CDD\|213672	TIGR01990, bPGM, beta-phosphoglucomutase. This model represents the beta-phosphoglucomutase enzyme which catalyzes the interconverison of beta-D-glucose-1-phosphate and beta-D-glucose-6-phosphate. The 6-phosphate is capable of non-enzymatic anomerization (alpha <-> beta) while the 1-phosphate is not. A separate enzyme is responsible for the isomerization of the alpha anomers. Beta-D-glucose-1-phosphate results from the phosphorylysis of maltose (2.4.1.8), trehalose (2.4.1.64) or trehalose-6-phosphate (2.4.1.216). Alternatively, these reactions can be run in the synthetic direction to create the disaccharides. All sequenced genomes which contain a member of this family also appear to contain at least one putative maltose or trehalose phosphorylase. Three species, Lactococcus, Enterococcus and Neisseria appear to contain a pair of paralogous beta-PGM's. Beta-phosphoglucomutase is a member of the haloacid dehalogenase superfamily of hydrolase enzymes. These enzymes are characterized by a series of three catalytic motifs positioned within an alpha-beta (Rossman) fold. beta-PGM contains an inserted alpha helical domain in between the first and second conserved motifs and thus is a member of subfamily IA of the superfamily. The third catalytic motif comes in three variants, the third of which, containing a conserved DD or ED, is the only one found here as well as in several other related enzymes (TIGR01509). The enzyme from L. lactis has been extensively characterized including a remarkable crystal structure which traps the pentacoordinate transition state. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	9.64028e-85
NC_022603.1\|WP_043946074.1\|50166_50532_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|377579	pfam05973, Gp49, Phage derived protein Gp49-like (DUF891). This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.	4.5177e-26
NC_022603.1\|WP_023176480.1\|52054_52672_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	9.14072e-42
NC_022603.1\|WP_003109035.1\|53223_54078_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.57522e-111
NC_022603.1\|WP_023176468.1\|40577_41864_+\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	3.61243e-104
NC_022603.1\|WP_003125439.1\|54224_54458_+\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	3.66086e-10
NC_022603.1\|WP_023176472.1\|44938_45664_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	2.77095e-28

>NC_022603.1|WP_023176474.1|46208_47033_-|AAA-family-ATPase
MAKVITYGNFKGGTGKTTNSAMMAYMLSKLGYKTLLADLDPQANATSLYLHTKQRITNNIVTFDKTLMSAIADEDLSDIIIEIKDNLYLLPSFADFTSFPLFLEKKFPNSQLKRVTFLKGLIEKIKDDYDFILIDVPPTLSTYTDSALLASDYTIIVLQTQERSLVGAEAYVGYLQELVDNYDANFDILGVLPVLLKNNSKVDEATLATAKEKFGEENLFKNLVKNMERLKRYDIVGIVDSDLDNKYDIHDKRVMALYKKVTEEMLSRLKEFDS
>NC_022603.1|WP_023176473.1|45771_46140_-|hypothetical-protein
MADSLLNKNKNKGKRNLLERKEEVKPKEAFNRSSLFTVDESQQDQFDKKKEPIQKSSKGKTTTIRCAADTSHRLNAIITSFSLNSVNELLEILLDNYEASLTQDERREIKTLQEVYQRKSIK
>NC_022603.1|WP_023176472.1|44938_45664_-|Fic-family-protein
MNKFFKSITSDYFEDILVRLAHHSAGIEGNTISLPATVSIIVNGTLPISSGATVREFYEIENHKQAFDHMINHLINEETLSTTIIKEIHADLTDRLQYDKGQFKKNENMILGAEFQTSSPSETPLFVSQLIDNLNYRLSISKDREAKLMAILDTHIQFERIHPFSDGNGRTGRMMMNYSLLQEGFPPLIIEKDTKAQYVEILATQDVDSFVTFAKSILDKETKRMIAFQNMDQEKIKEIEE
>NC_022603.1|WP_023176471.1|43294_44596_-|M20-family-metallo-hydrolase
MSQKTIFNLKEKLLETYDVSFDYNGISGKRLAERLGALSKIGLTEQNGSYRTGFSFEEKEAKELVMKWMKESGLSVHQDGAGNVFGRLEGKRPDVPAILSGSHVDSVPNGGHFDGPLGVLSALEVAEAWRETEFTPEKPFEVVIFSDEEGSRFHGGLNGSEAFMGSGDLDEKIKKKDTNGESFEKVLQDVGLSLESYSNAKRDLDDIETFIEIHIEQGKRLEKEELPCGIVTGIAGPHWLEYTFQGEAGHAGNTPMNDRKDALLAASEFIVKLTQIPQQINDTAVATVGKLHVEPNGVNVIPGKVTLYVDSRDIYEESRDTLVNRIIQLGEEIGISHKLSVTYKETLKSPPVPISEDRQELLEEAMKVNGIRPYRLPSGAGHDAMVLGAQIPIVMLFVKSKDGISHNPGEWSDLNDCIQTIHVLKTYIEKLQY
>NC_022603.1|WP_144080658.1|42888_43068_+|hypothetical-protein
MMIIFGVIKEIIVNHYNNGTLQSRKEFLDRLLEKNMEETAISISEYELLKETIDDLSTK
>NC_022603.1|WP_023176469.1|41917_42682_+|ChbG/HpnK-family-deacetylase
MRLLMRADDLGFCEAINYGIHKTVEQKNITCVGLMPNAEAAEHGYNLIKEYDISLGQHTNICLGKPVSNPKYIPSLVDENGVFYRSKDINSRKFDTIDLKECEIEVEAQLKRFVEITGKYPDYFEGHAVFSEIFFQALRNVAKKYNLFFCNPMDPNWQKENNVFLPKMYKLDNNNCYDPEKYLEELTHNLLKNKNSILIFHPGYLDQYVLENSSFTKIRTLELDFLCSDYLKKWKKNNHVQFINFKELKLIKAT
>NC_022603.1|WP_023176468.1|40577_41864_+|PTS-sugar-transporter-subunit-IIC
MNIITNFIENYVTPIGIKMANNKIVNVISTGLTMTLPLIILGAIFTLLSSLQIGPYQQFVTSTGLKPLFSLIGKFTVDMLSIYVAFTTAYTYLRNTKDMETGAISAGLISILSFFIMTPLTTIMINDNLVEVLSFDFLGSKGLFTALLTGVLVGYVYVFVVKHNWTIKMPESVPEFVANSFNALIPAFILSFVFLTINGLFNIFTQATFGEWLYDILSAPLSALSGNLATHLLLTFLASLFWFFGLHGGQITGPFIMILFMQAGMQNQVAYAAGQSLPNILTIGLGGLVSLGGIGCTIGLAINLLLFSKSSQYKSLGKLTIIPSIFGINEPLIFGMPMILNPIMAIPFFITPQIINILTYVVMKLGLVGLPRLAMFTPGTPLLLDGMLMSGLSGVFWQIIMIVLSVAMYYPFFKVADNKLYTAEMEII
>NC_022603.1|WP_023176467.1|39589_40252_+|beta-phosphoglucomutase
MIKGIIFDLDGVITDTAQLHYNAWKKLAEELEIFFDYKFNETLKGVSRMDSLDKILIYGKKQNDYSTAEKEVLAEKKNNHYIQELNKLNSESILPGIKGVLMYLKEQNLLIALASASKNAPIILKKLELYEKFDVIIDPATLKEGKPNPEIYLNAVEVLGLQNSEVIGIEDAVVGVKAVNSANILSVGVGDKMVLKEANVVISTTKELLNCIKRIQREQL
>NC_022603.1|WP_023176466.1|37905_39597_+|beta-N-acetylglucosaminidase
MIISSKLNLTSTPFNLNEEEIVNVHNIVADMSLDEKVKHLFAPITFSTDPEFLKKWVQKYQPSTVTFRPSAKADLQNAYRILQENSKIPLLLAGNLEDGGNGLALEGTYYGKPMQIAATDNTFYSEALGEIAGTEAAVLGANWSFGPIVDIDLNWRNPITNLRTFGSDVERVKRMSLAYKKGFEKSGGILAAKHFPGDGTDERDQHLHVTFNHLTVDEWWETYGSVYQELIEDGIQSIMVGHIAFPAYSKKKGVHAKQIKPATLAPELLQDLLRDELAFNGLIVTDATPMVGFASAEARETALPKAIAAGCDMILFNRNYDEDILFMHQGIKDGLVSEERITEAVIRIIATKMTMGLFNKKKIVPGPKALEEIGTVENKNKARDLAKESVTLVRDRDTLLPLTKGKRIFVVPIDLPKDSEIVNQFISGLRSQGAMIEHQTPEKFDFSWADKSLKELREKYDYAIYLSAKQPRSNQTQVRLNWLPFLALNTPWFLHEVPSLFISFGNPYHLIDVPYISTYINAYADNQETIEETVEKLMGNDTFRGKSPIDPYCGNREEIHLYD
>NC_022603.1|WP_023176465.1|36500_37919_+|glycoside-hydrolase-family-1-protein
MTNVKFPTDFLWGVSSSAFQIEGASTEDGKGLSTVDTRKVKEGIADTAIASDHYHHWKEDISLLAEMGVKTYRFSISWTRIFPSGEGEVNQKGLQFYDNLIDELLAYNIEPLVTMYHFDLPQNLVDKYQGWLSRETIDCYEKYAEVLFTHYGDRVKNWISINEELMVMYSQDFNGIRNLDEKQYKKAVFQMMYHMSLAEKKAFKLCHELVTDGKIGPANAFQNIYPATSDPLDVEAAMNAEEFLSYMLLDLSVKGKFPENTLRYLQKENLAPETLPEDEEILKNNKPDYICFNYYASLCAEVYTGLADDHMPPFFRSNMYRIVPNQTKSLSEWMVFGIDPVGMRISMRKLYNRYELPLMITENGYADSEELSDTFEINDEKRIGYLQLHLLECSKAIDEGIPLLGYSAWSFLDSLSGREGFSKRYGLVYVNRTDDDTKDLKRYKKKSFYWYQNAIKQNEFIVDEGKKNYDNK
>NC_022603.1|WP_023176476.1|48918_49668_+|hypothetical-protein
MILKEVVTNYLFNDEIIQTIANYWKKHYYQEEEVTVGNIKEKLVKLREELDRVDTTDAASRCGYSLTAKWIEDAFTDEIVIDIFCTFNEDGKHYSVDYLSFEEMLHYNVIFPLDIPKIDFLSELLWEITFEGFTEESKTKSRRELENRIQESDEVQKSMADVKAFIVFFKEKCSTDKRISIIDHFQPLTDSVVEDWSDIFDETEDESSEVSFWSNVAVQKQDEQLLEEFLQVFKDEYDSFVDQKAQKKL
>NC_022603.1|WP_052326534.1|49898_50141_-|helix-turn-helix-transcriptional-regulator
MENPEFAEAWKETEASYQAATILLRIREEKQLTQSELATLTGKKQSYISRVEKGTQNISVQTLSNIVESVGGKLKLEVVV
>NC_022603.1|WP_043946074.1|50166_50532_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MKKYNFDIYEKENGETPFLDYLDSLDVKSRAKVLRAITIVEDFGVHSPPGYIDHLDDGIYEIRVKFSSNIFRCLYFHFTNNKYIITHGFTKKTQKTPAREITKSKEYRKDYLERKGEKDGK
>NC_022603.1|WP_023176479.1|51208_51781_+|DNA-starvation/stationary-phase-protection-protein
MTENKATQERTPQERLQEEQEHKEHVHHTKINAAAISDHLLGNMHTLHVKLHQYHWYVNGANFFTLHEKFEELYNQNEEWFDKLAERLIISGHKPASTTAEFEKYSMLSEDAINKYAKAEDMVENIIEDFRSTRELTIRAIRLVQDEGDDALEDTLIAFKNDLDKNIWMLQAFIGKEALEDDDAFDEDED
>NC_022603.1|WP_023176480.1|52054_52672_+|Crp/Fnr-family-transcriptional-regulator
MDRIAGKAHTNHYQKGEFLFRSQEKDDALYIVNRGKVRIYRLSDSGKEQLVRILNPGDFTGEWTLFNPDAVHEEYAEATRDTSVCMIQQQDVQEFLKEYPAISLKLLGEMSQRLESSERQTAQVAVESVITRLVLFLAENVEPEMGNSPTITLPMAKKDIASYLGTTPETISRKFGELEDEGLIQQLSGKRIKIQDLDDLLLYSE
>NC_022603.1|WP_035020774.1|52900_53239_+|hypothetical-protein
MHYFWVIVAIMLSAAGAFFVVPFTKNTIGGEAKTSNVVEADRLAMEKEEEVVKGAGVIGHGKVAYYEASDQGDKSVFTVWFPWSLAGILFSITMTRMTRKIEEMEQIEWNSY
>NC_022603.1|WP_003109035.1|53223_54078_+|prolipoprotein-diacylglyceryl-transferase
MEFVLGVLNPHAVEIGSVVIHWYGVIIAAGILAALQLSTKEAKKKGLEEDTIIDMALWAIPIGLLGARLYYVLFELGYYLQNPGQILAIWNGGIAIYGGLIAGGGTLYWYAKKKGTSLALVLDILAPNVLLAQSIGRWGNFMNQEAHGGPVTRQFLENLYLPEFIIEQMNINGTYYHPTFLYESLWSLLGFVLIVTIRNRKQLLRQGEVALSYVLWYSVGRFFIEGMRTDSLWIGEWIRVSQALSLALFIGAIVVWFIRRQDYPPISYYSDGNKGQKKTIKMVN
>NC_022603.1|WP_003125439.1|54224_54458_+|heavy-metal-associated-domain-containing-protein
MEKAILQLETLSCPSCMQKIEGALKSVNGIDKDSIKVLFNSSKVKTNFDSAVTSIEEIQKAIENVGYPVLKAKVKAA
>NC_022603.1|WP_023176482.1|54777_56640_+|heavy-metal-translocating-P-type-ATPase
MQQYILSKKNVITVISGLLIALGFFSHFVLENVGLSEWSLIIASVFGITPIAIQAFQAMKVKVISIDVLVSIAAIGALFIQNYEESAIVTFLFLFGHYLEQRTLNQTRSAIKELTEMAPESALKQMDNGEFEEVEVDDVDEGDILLVKTGAKVPVDGTVLTGEGHINEASITGEAVPVNKLADAEVFAGTILENGTIQIRADRVGEDTTFGKIIELVEEAQDSKSEAERFIDRFSKYYTPAVLVLAIVVWAFSQNIELAITILVLGCPGALVIGVPVSNVAGIGNGARNGVLLKGSEVIQDFSNVDTIVFDKTGTLTVGNPTVAATELYEKDSAETLGYLASVERESDHPLAKAVLNQIGETNFYPVEGTEVVKGGGIVSSIAGHRVAVGNVALMEKEKVTLSKKVQKDVKRFEQQGNSLVLTAVDGELKVLMGIRDQVRPGVKANLQELKDLGVKNLVVLSGDNQGTVDVVAGELGLTEAHGHMLPEDKSAYIGKLQQRGQIVAFVGDGVNDSPSLALADIGIAMGSGTDVAIETSDVVLMNSNFSNLPHALGIVKATANNMKQNIAISIGVVLVLLTSVFFSEWMNMSIGMLVHEGSILVVIFNAMRLMKYKLKGRKE
>NC_022603.1|WP_023176483.1|57024_57576_+|tyrosine-type-recombinase/integrase
MAYNVQPLRTQQEINDFLFCLRRNKNADRDVFLFLIGINSGLRMSDIVKLKKKDLISSKNPRIIEKKTGKTRILYLSSLQDLIQDYTKDLAPEDYLFPSTKGGHVEVNTVYQMFQKVAKLLGRDDIGTHTLRKTFGYHYYKKTKDVATLMEIFGHSSEKITKRYIGINEDEISETLLNFRLGF

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022603_1	1.1\|23755\|25\|NC_022603\|CRISPRCasFinder	23755-23779	25	NC_022603	Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR64, complete sequence	23755-23779	0	1.0
NC_022603_1	1.1\|23755\|25\|NC_022603\|CRISPRCasFinder	23755-23779	25	NC_020208	Enterococcus faecium ATCC 8459 = NRRL B-2354 plasmid pNB2354_1, complete sequence	6855-6879	0	1.0
NC_022603_1	1.1\|23755\|25\|NC_022603\|CRISPRCasFinder	23755-23779	25	NC_022603	Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR64, complete sequence	23704-23728	3	0.88
NC_022603_1	1.1\|23755\|25\|NC_022603\|CRISPRCasFinder	23755-23779	25	NC_020208	Enterococcus faecium ATCC 8459 = NRRL B-2354 plasmid pNB2354_1, complete sequence	6906-6930	3	0.88
NC_022603_2	2.1\|47163\|102\|NC_022603\|CRISPRCasFinder	47163-47264	102	NC_022603	Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR64, complete sequence	47163-47264	42	0.588

1. spacer 1.1|23755|25|NC_022603|CRISPRCasFinder matches to NC_022603 (Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR64, complete sequence) position: , mismatch: 0, identity: 1.0

caatgaaagtatggagatgggacag	CRISPR spacer
caatgaaagtatggagatgggacag	Protospacer
*************************

2. spacer 1.1|23755|25|NC_022603|CRISPRCasFinder matches to NC_020208 (Enterococcus faecium ATCC 8459 = NRRL B-2354 plasmid pNB2354_1, complete sequence) position: , mismatch: 0, identity: 1.0

caatgaaagtatggagatgggacag	CRISPR spacer
caatgaaagtatggagatgggacag	Protospacer
*************************

3. spacer 1.1|23755|25|NC_022603|CRISPRCasFinder matches to NC_022603 (Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR64, complete sequence) position: , mismatch: 3, identity: 0.88

caatgaaagtatggagatgggacag	CRISPR spacer
taatgaaagtatggagatggaacac	Protospacer
.*******************.***

4. spacer 1.1|23755|25|NC_022603|CRISPRCasFinder matches to NC_020208 (Enterococcus faecium ATCC 8459 = NRRL B-2354 plasmid pNB2354_1, complete sequence) position: , mismatch: 3, identity: 0.88

caatgaaagtatggagatgggacag	CRISPR spacer
taatgaaagtatggagatggaacac	Protospacer
.*******************.***

5. spacer 2.1|47163|102|NC_022603|CRISPRCasFinder matches to NC_022603 (Carnobacterium inhibens subsp. gilichinskyi plasmid pWNCR64, complete sequence) position: , mismatch: 42, identity: 0.588

aaatctacaaatctacatgtagacgtatctacaaatctacaaatctacatgtagacgtat	CRISPR spacer
aaatctacaaatctacatgtagacgtatctacaaatctacaaatctacatgtagacgtat	Protospacer
************************************************************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022606

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_022603

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection