CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022657	Actinoplanes friuliensis DSM 7358, complete sequence	14 crisprs	cas3,csa3,RT,WYL,DEDDh,Cas9_archaeal,c2c9_V-U4,cas4,csx1,DinG	5	10	0	0

1. NC_022657

CRISPR-Cas detection and classification

Crispr_ID: NC_022657_2

• CRISPR_ID: NC_022657_2
• CRISPR_location: 71483-71568
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_022657_2

Consensus_repeat	Method
GCAGCCGTCTCGGGCCGCGCAAA	CRISPRCasFinder

spacers of NC_022657_2

>2.1|71506|40|NC_022657|CRISPRCasFinder
GCTGGACGCAACCTCAGGCCGACCCTGATCGGCTGCCTGA

CRISPR arrays and Neighbor proteins around NC_022657_2

CRISPR arrays

The CRISPR arrays of NC_022657_2

>merge|NC_022657|2|71483-71568|CRISPRCasFinder
GCAGCCGTCTCGGGCCGCGCAAAGCTGGACGCAACCTCAGGCCGACCCTGATCGGCTGCCTGAGCAGCCGTCTCGGGCCGCGCAAA

>NC_022657|2|2|71483-71568|CRISPRCasFinder
GCAGCCGTCTCGGGCCGCGCAAA	GCTGGACGCAACCTCAGGCCGACCCTGATCGGCTGCCTGA
GCAGCCGTCTCGGGCCGCGCAAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023357298.1|73756_75898_+|(Fe-S)-binding-protein	unknown	unknown	gnl|CDD|223325
NC_022657.1|WP_041840477.1|72317_73127_-|DUF881-domain-containing-protein	unknown	unknown	gnl|CDD|377575
NC_022657.1|WP_041841620.1|69120_69951_-|class-E-sortase	unknown	unknown	gnl|CDD|320679
NC_022657.1|WP_041840478.1|81375_82584_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|376540
NC_022657.1|WP_041840476.1|61924_63424_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl|CDD|223843
NC_022657.1|WP_023357292.1|66312_68106_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl|CDD|270916
NC_022657.1|WP_023357293.1|68165_68816_-|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl|CDD|181107
NC_022657.1|WP_148307827.1|80558_81386_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023357288.1|60464_61892_+|protein-phosphatase-2C-domain-containing-protein	unknown	unknown	gnl|CDD|223704
NC_022657.1|WP_041840475.1|59194_59980_+|DUF3662-and-FHA-domain-containing-protein	unknown	unknown	gnl|CDD|378850
NC_022657.1|WP_023357297.1|73296_73560_+|cell-division-protein-CrgA	unknown	unknown	gnl|CDD|377706
NC_022657.1|WP_023357290.1|63420_64926_+|penicillin-binding-protein-2	unknown	unknown	gnl|CDD|223839
NC_022657.1|WP_023357299.1|75894_76557_-|GPP34-family-phosphoprotein	unknown	unknown	gnl|CDD|377552
NC_022657.1|WP_023357294.1|68824_69109_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023357300.1|76658_77993_+|HlyC/CorC-family-transporter	unknown	unknown	gnl|CDD|224173
NC_022657.1|WP_023357287.1|59985_60468_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|224630
NC_022657.1|WP_023357303.1|80040_80562_+|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|132028
NC_022657.1|WP_023357291.1|64927_66316_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NC_022657.1|WP_023357302.1|79076_79961_+|hypothetical-protein	unknown	unknown	gnl|CDD|214598
NC_022657.1|WP_041841621.1|77985_79011_+|HlyC/CorC-family-transporter	unknown	unknown	gnl|CDD|224173

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023357298.1|73756_75898_+|(Fe-S)-binding-protein	gnl|CDD|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	5.42988e-84
NC_022657.1|WP_041840477.1|72317_73127_-|DUF881-domain-containing-protein	gnl|CDD|377575	pfam05949, DUF881, Bacterial protein of unknown function (DUF881). This family consists of a series of hypothetical bacterial proteins. One of the family members YlxW from Bacillus subtilis is thought to be involved in cell division and sporulation.	1.25994e-50
NC_022657.1|WP_041841620.1|69120_69951_-|class-E-sortase	gnl|CDD|320679	cd05830, Sortase_E, Sortase domain found in the class E family of sortases. Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	7.63306e-63
NC_022657.1|WP_041840478.1|81375_82584_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	1.33064e-06
NC_022657.1|WP_041840476.1|61924_63424_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl|CDD|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	3.08563e-74
NC_022657.1|WP_023357292.1|66312_68106_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.6289e-125
NC_022657.1|WP_023357293.1|68165_68816_-|aminodeoxychorismate/anthranilate-synthase-component-II	gnl|CDD|181107	PRK07765, PRK07765, aminodeoxychorismate/anthranilate synthase component II.	2.79034e-139
NC_022657.1|WP_023357288.1|60464_61892_+|protein-phosphatase-2C-domain-containing-protein	gnl|CDD|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	3.15842e-73
NC_022657.1|WP_041840475.1|59194_59980_+|DUF3662-and-FHA-domain-containing-protein	gnl|CDD|378850	pfam12401, DUF3662, Protein of unknown function (DUF2662). This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with pfam00498.	6.32554e-50
NC_022657.1|WP_023357297.1|73296_73560_+|cell-division-protein-CrgA	gnl|CDD|377706	pfam06781, CrgA, Cell division protein CrgA. CrgA is a trans-membrane (TM) protein, first described in Streptomyces as being required for sporulation through the coordination of several aspects of reproductive growth. In Mtb (Mycobacterium tuberculosis ) CrgA is a central component of the divisome, and consists of 93 residues with two predicted TM helices (TM1: residues 29-51; and TM2: residues 66-88). CrgA facilitates the recruitment of the proteins essential for peptidoglycan synthesis to the divisome and also stabilizes the divisome. Reduced production of CrgA results in elongated cells and reduced growth rate, and loss of CrgA impairs peptidoglycan synthesis. CrgA has homologs in other actinomycetes.	5.42644e-33
NC_022657.1|WP_023357290.1|63420_64926_+|penicillin-binding-protein-2	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	1.17438e-78
NC_022657.1|WP_023357299.1|75894_76557_-|GPP34-family-phosphoprotein	gnl|CDD|377552	pfam05719, GPP34, Golgi phosphoprotein 3 (GPP34). This family consists of several eukaryotic GPP34 like proteins. GPP34 localizes to the Golgi complex and is conserved from yeast to humans. The cytosolic-ally exposed location of GPP34 predict a role for a novel coat protein in Golgi trafficking.	1.3837e-47
NC_022657.1|WP_023357300.1|76658_77993_+|HlyC/CorC-family-transporter	gnl|CDD|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.55185e-129
NC_022657.1|WP_023357287.1|59985_60468_+|FHA-domain-containing-protein	gnl|CDD|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	1.31532e-19
NC_022657.1|WP_023357303.1|80040_80562_+|SigE-family-RNA-polymerase-sigma-factor	gnl|CDD|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	3.81167e-41
NC_022657.1|WP_023357291.1|64927_66316_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.72795e-115
NC_022657.1|WP_023357302.1|79076_79961_+|hypothetical-protein	gnl|CDD|214598	smart00282, LamG, Laminin G domain.	1.13907e-07
NC_022657.1|WP_041841621.1|77985_79011_+|HlyC/CorC-family-transporter	gnl|CDD|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.40837e-65

Protein sequences

>NC_022657.1|WP_041841620.1|69120_69951_-|class-E-sortase
MAAEPDAGAGGDEGDKPRRGEKVVKLRPEQTDEGYKSVYSELTRPTLGSRIRAGVRVSGELMITFGLIVLLFAGYEVFGNSAKVENEQDTLANQLDDQWNDPTVAPSAGPTKAAPAAPGKNLVGRLYIPKLGMEWVVVNGVRPQDIRYAPGHYPDTADPGKVGNFSVAGHRIRKIFWRLDELQPGDVIGVETRTNWYVYKVSRSEVVKPSAVEVVAPVPGKPNAKPTKAMLTLTTCNPKFNNYQRLIVHAELVDTVKRDASQPEAGKPAEMKKTKA
>NC_022657.1|WP_023357294.1|68824_69109_-|hypothetical-protein
MYAWIWRKLPFGLWGKLTGSLAMAAAIGALLWYVVFPWATPLLPFDDVQVGTGTEQGGPAEQDPNAVPGADDPGLGPDEIPYNEHTNDPEPTAS
>NC_022657.1|WP_023357293.1|68165_68816_-|aminodeoxychorismate/anthranilate-synthase-component-II
MRILVIDNYDSFVFNLVQYLGQLGAECEVRRNDEITVADVADFGAAGVLLSPGPGTPERAGIMMDVITAYAGKIPMFGVCLGHQAIGAAFGGTVTRAPELLHGKTSSVQHKGAGVLAGLPDPFTATRYHSLAVLPETLPEELEVTGWTESGVVMAMRHRTLPIEGVQFHPESVLTEGGHTMLANWLASCGLPEALDRAPELAAEVETRRRSAFAGA
>NC_022657.1|WP_023357292.1|66312_68106_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MTAQARLLGGRYQVGELLGYGGMAEVHKGRDLRLGRDVAIKMLRTDLARDATFQERFRREAQNSAALNHPAIVAVYDTGEEVSSAGEKQPFIVMEFVNGRTLKEVLAAEQRLQQRRALEIIADIDAALEFSHRHGIIHRDIKPGNVMITQNGQVKVMDFGIARALASGATTMTQTSAVIGTAQYLSPEQARGESVDARSDVYAAGCVLFELLVGHPPFVGDSPVSVAYQHVREDPKAPSDINREVSPDVDAIVLKALAKNPLNRYQSAQEMRADALRAVSGRPVLATPVMNEAETMAMAGPPMRQQTAMTRTIPAGGPRGPQPPERKTSSWVMAVLAALGVLAVVALGIGLTLANRNDDPETPATAAVPKVTGLSENDARKTLTDAGFTAVTVGDPIETDDCKDRVERQTPEANATTRVDQAVTLQLCSSPAPTKVPTGLVGSTRDAAESALEDAKLKPKFVEKDSSAPEGQVLSVEDEGDEVKRGTTITVTVSRGNLSPVPDVRGKLQDTAIALLEQAGFKDVKVQETNQEGPVGTVVEQTFANQKKSKSTTITITVIVAQEPEPGDSTDPTDPTDPTDGPGAGGDGGGLDGIIGN
>NC_022657.1|WP_023357291.1|64927_66316_+|serine/threonine-protein-kinase
MISPGVTLGGRYRLDERIAGGGMGDVWRGTDEVLGRTVAVKILLPALLDEPGFAERFRGEARTMATINHPGVVDVYDYGSDQQLAFLVMEYVEGDALSRTLSRVGRLTPARTMALVAQAADALQAAHANGIVHRDVKPGNLLVRPNGTLVLTDFGIARSAMVGQLTVAGSVLGTASYISPEQASGAVATAASDVYALGVVAYQCLSGHRPFDGSTPIEIAMKHVRDTPRPLPADIPQAVRAIVDRALAKDPGARWPTASAMAAVARQAASSLTTQVQQPAVNGSSAGRPQSGGPTMTRPQSSGPSMANRPHSGAPTSGPGGHPMSGQGRPPYPPIPRPVSGAQARGAASVPPAQQPYRHPSAPPMQQHQPMQGGKQADGSGGRQVLIVLAVVLALLVLLCAGVISFLLNQGNTNAMGDHGNRSTVVVAGSADQRTSATSYRLTKQAAAPHSLNHATEGRQTL
>NC_022657.1|WP_023357290.1|63420_64926_+|penicillin-binding-protein-2
MNAPLRKAGVVILVLFGMLFANLNWVQAYKADDYRTSDYNGRVRVAEYETPRGVIEAGGEALAQSKATDDTLKYLRVYPEKKVYAPIIGYKPVDNAETGIERSENDFLSGASDKLFADRVSAMFTGDKAGGGNVVLSVKPKAQEVAYKQLTNNERGAKAGSAVAIDPRTGAIQALASFPTFDPNPLVSHDNKVATAAFKDLNADKDKPLLNRALSETYPPGSTFKVIISAAALQDGYEQSTEIPAGQTYTAPGSGAPIKNSEDQTCPGAQVTLKEALTDSCNTGYAQLGVKLGGDKVKKAAQAWGFEQNDLTVGNLQEGTGLPVAASKTGEIKNPDGSTDQAGLAQSSIGQKDVRMTTMEGALMAATVANGGKQMRPYLVQQLLSPDRRPIYNASPQTLRTPVNGQVASDLKDMMVSVVENGTGQRAKIDGYEVGGKTGTAQNAVDADDHGWFIGFAYNDKGEAVSAVCVMLENVPGGHASAEAARIAGLIMKAAAGRGGD
>NC_022657.1|WP_041840476.1|61924_63424_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MTAPAIPAPTPASTGEMPRVPGTKTGRNAELGLLAFAMVIVAAYGATVEANQYDKITPTFWVPAALLSVLFLGLHLVVRFVAPHADPVLIPAVALINGLGVGFLRRLDIAKAISEKQPELGVFAGVGGRQLAWTLVALVLAAVLLLIVRDHKTVSRYAYTLGLVGIVLVMIPAVLPSSISEVNGAKLWIKMGAFSIQPGEFAKLALVSFFAYYLVRKREVLSLASRRFLGIDFPRGRDLGPVVTVWLLSLLVLVFEKDLGTALLYFGLFVVTLYVATERASWLIIGLVMFFGGVYVAYLLGASIGGPFANFYDRATVWLDPFASENYERIGGSYQLVQGLLGLGTGGMFGTGPGAGSPGFVPEVRNDFIFAGMGEEIGLFGLSALLVCYLLIVERGLRAALGVRDSFGKLVAGGLAFTLGLQVFVILGGITGLIPLTGQTTPFLSSGGSSLMANWLLIAMLLRISDAARKPANGGPAASGGPKQPPAQLHGAMTEVIKP
>NC_022657.1|WP_023357288.1|60464_61892_+|protein-phosphatase-2C-domain-containing-protein
MTLTLRYAAQSDRGLIRDGNQDSVYAGPRLLAVADGMGGMAAGDVASNIVIAAMAPLDEDVPGDALVDALRHAVGTANQTLRDTVDANPHLEGMGTTLTAVLFSGSKIGMVHIGDSRAYMLRQGEFSQITKDDTYVQMLVDEGRISPEEASSHPQRSLLTRALDGRDIDPEYSVRQVLKGDRYLICSDGLSGVVSAETIGESMRDIQDAQACCERLVQLALRGGGPDNITVVVADATDADIMEQAPIVGGAAARDRGNSTVADASSAAARAAALQAPPRPAAPENTSYDRDEADQPKRHPVRTSLLVLLLLGVLGGGLYLGWQYTQDQYYVGATEQGQLAIFRGVPGQIAGLDLSSVHETSEARLDDLTTVAQDRVKQGIHADSNPDAQRRLAELTSDEPSNPNLKPICSPSSPAPTVTQPVNPSGAPSAAGKTTSPSRNTPSSAPALAPATTPDAQPSDSAPPVVDPVGCRPVD
>NC_022657.1|WP_023357287.1|59985_60468_+|FHA-domain-containing-protein
MPEFVLTVARFGFLILLWIFVFTVVGVIRKDLFAGVRSKSIVASPRGVGGAVIQGRPAKAKRGKAARQLVVTAGQLAGTRITLGEAQITIGRAEDSTLVITDDFASARHARLVPRDGQWFVEDLGSTNGTYLDRGKVSGPTPVPLGVPIRIGRTSLELRP
>NC_022657.1|WP_041840475.1|59194_59980_+|DUF3662-and-FHA-domain-containing-protein
MSSEPEEEPVSVLQRFEKRLEGLVEGAFAKVFKGVVHPVEILNAMQREAEAHKAILAGGRTLVPNRYVIDLSPYDHSRLAPYAAALAQELAQSQAEFIGEQAWTVYGDVIVEIERGDGLDTGMFRVTAEVYTGGEVAPVQQPAYDAAPAYSPYDQQQQGGYQQHGHNGRNVGLVSGDGRTYPLQMGSTVIGRGDQANLRLPDVGISRRHARLDYDGSQVVLTDLGSTNGTMVNGQRVSAVALNPGDMIQLGTTTLTFRVDG
>NC_022657.1|WP_041840477.1|72317_73127_-|DUF881-domain-containing-protein
MEYTTGAPSWRLVLRRALGGLRPRRPGQRQRGWSIAVPLIGLAAGLLFTTSATTADGTSLRDDRRPQLAQLIADKRTRLDGREKRAADLRAAVDQDAAKLADVDEPVKSARARADAMRGGAGFTALRGPGITVSLNDSPQRITGTGVDAPENDDLVVHQGDVQAVVNALWAGGAEAMSIMDVRVISTSAVRCVGNTLLLHGQVFSPPFKITAIGEPTAMHRALESAEGVQQFRTAVADFGLGYQETVERNVTVRAYDGSSDLRSAEVTE
>NC_022657.1|WP_023357297.1|73296_73560_+|cell-division-protein-CrgA
MPKSQVRKKKVYTPPTDIRPAAAAASKKPSPVWLPITAVALIVFGISWLVVYYLSEQQYPVEAWRYWNLLVGFGCMVASLGILSRWR
>NC_022657.1|WP_023357298.1|73756_75898_+|(Fe-S)-binding-protein
MGTAQIIATVLAAAVTIVAVALAVRAVMQMTAVIRQGKPDPERFGDKGARTKTMLVETAGHTRMLKWGVVGAAHWFVMVAFVVLSLLVLEAYFEVVSPELGLPVIGHWVVFGLATEWIGVLGTIGILVLVAIRQRDKRKKVSRFTGSTMWQAYFVEAIIIAVLICGFLIRGFKVATDHFEYPFWATPVSHGIGALLPDWENGATWTALVKILISMSWLITISLNVTMGVAWHRFLAFFNIYFKRSPKKPAGSGMGALRPMMSQGKPLDFEEADPEKDQFGVAQVEQFTWKGLLDFSTCTECGRCQSQCPAWNTAKPLSPKLMILSLRDHAYAKAPYLLGGGGKDLTGEEKATEAQLAHMDVLALAEGNRPLIGTEEEQGVIDPDVLWSCTTCGACVEQCPVDIEHIDHIVDMRRYQVLIESSFPSEAGVMLRNLENKGNPWGAPQNTREDWTKGLDFEIKRVGEEEFDYLFWVGCAGAFEDRAKKTTRAVATLLHEAGVDFAILGEGETCTGDPARRIGNEFVFQMLAQQNVETLQEAKVKRIVATCPHCFNTLGNEYEQLGLKVEVVHHTQLLAHLVAEGKLTPVQPVDGGVTYHDPCYLGRHNRVFEAPREVLGSAIEGGLTEMPRNSERSFCCGAGGARMWMEEKIGKRINVERTEEALATGAKTIAVGCPFCYTMIGDGVTGKGEQENVEVIDVASVLLRSIKGDKAPA
>NC_022657.1|WP_023357299.1|75894_76557_-|GPP34-family-phosphoprotein
MNLAEEFALLAYGDDGAPDTDTMRLDNGLGGALLLELALTGRVDVEDKKVIVRDGTPTGDPLVDQALERIVADDKQRKPGQWVTKFAKDARKLTLDRLVSQEVLVREQDKVLLVFPRTRYPAPHGGRPIPETEARQRLTAAVTRTEAVEPRTAALCALVAATDLDRKVFRDLDRNLVKTRLKEISQGAWAADAVKKAIEEIQLAIIMTVVAATSATATTS
>NC_022657.1|WP_023357300.1|76658_77993_+|HlyC/CorC-family-transporter
MDGLFLSAVLPLAAFALLTAGNAFFVAAEFGLVTVDRVEIAKQAEAGDRRARTVQNALHELSFQLSGTQLGITLTALLTGYLAEPALSRLFRPAIEPLFGGATETVTHVLSLVFATLVSMLFGELVPKNAALARPMRVALATAAPLRTFSKLFKWLISALNGSANWLVRRLGIEPQEELASARSPEELGLLAAISARAGALPTETATLLRRTIRFGEKRAAKAMTPRVDVVGLKTTASVADLIATSRQTGHTRFPVYESTLDLVVGVVGISDALGVPPERRAATPVSSVAREPVLVPESLDLDKVLAALRAADADLAIVVDEYGGTDGVVTVEDLIEELVGEIADEYDLDFTEAGSVELTAPDGDKTYLVDGLLREDEVAEQTGFRLPEGPYETLAGFLLSRLGHIPVAGESLEDDGWEFTVMEVDRHRIEQVRVVAPPEPADD
>NC_022657.1|WP_041841621.1|77985_79011_+|HlyC/CorC-family-transporter
MTELLVTVVLLLGNALFVGGEFALIASRRTALEPLAATSRRARWALSAMNQIPLMIAGAQLGITICSLGLGAIAEPALAHLVEGPFEAIGMPERAVHPVAFVLALGVVVFLHTVVGEMVPKNITLAGPERSALVLGPFMLAFCTATKPILTAMRWAAKIVLSLWKVEATDAVKTVFTAEELAGMVTQARAEGLLGTEQYARIHAALGLNVRTAADTLQPWSGVTTVADDASPATIEAIATRSGRSRFPVVQRETRRVLGFVHVKDILGYEGAQRRLPIPAEIIRPLAVVPPERTLADLLLTMRRDRRHIVLVSDGRRPLGVIALDDVLHAVVGEPSVRSVV
>NC_022657.1|WP_023357302.1|79076_79961_+|hypothetical-protein
MFDNRRSSRSARPRVSPFGVLVAAAALGAGLLAVTQFTPKPHISPQYVALQPRPSAGVLTGVTSGFAAHQQRGGAGQVGIAAAPVAVRYTFDGGIHQPITDLGGAYALRPLAQNGGTLRLVPQGKGLAVKYPARCTLTRERRCPRAILEGLRDDRLNPGTRPMQYGASVLMTHADLSDGANVFQKGYSVGGVSQFKLQVDHKQGHPSCVIAGRARIYRAEPFMDVADGRWHNLMCARSRNRLTMVVDGVERASVPVPATLSIANAEPLRVGGKGPNKGNDQFAGQIDNVYLTIN
>NC_022657.1|WP_023357303.1|80040_80562_+|SigE-family-RNA-polymerase-sigma-factor
MVRSRRFDGLDTLIAERGNALLGTAVLLTGNRAAGEDLLQAALERLMRSWGRVREDRERYLRRTMYHLAIDQWRHRRRRPEVFLGHEPPGGPDATDALDLRDALIMALAQLSPRQRAVLVLRYWEQLTEPETAAELGCSVGTVKSTASRGLARLRELTSTWDLHHATLNGTGR
>NC_022657.1|WP_148307827.1|80558_81386_+|hypothetical-protein
MTTELEARLTESMHHQVDGLALSTDILDRATRRHQRRTTTIRIGYALGAAGLAGALAAGLSLGGGAAEPPAVVQAAPASMRLANAATASDNISYRIHLKSGSRVGDGAFDPRTASGYFRVPQDDSVTTEIMVNGTRYIGGEPPLGKLPADKGRGEKYGRYGQYPGKHKSLSLFGNGDAVVGAAAPNPAALFKALSQANATTSENPDGTFHFEYATTTGDVALNSDGRIARMTLTTTWRSTAKGRLDTGRFDTTIELSDYGLKVKVKRPADVVPTS
>NC_022657.1|WP_041840478.1|81375_82584_-|helix-turn-helix-transcriptional-regulator
MTPRRSGDTSVGGLIRARRLLRGWSVRYAASRAGVSHATWSRIERGLQAADNRFMVADIAGALECSPADLVSTEVPAPDRVTKAARARVLGLRRALIDIDLSEAPAGAALPMVELSRGVALVDALHQACDYAGAARLLPGLLSDLHTETAGPDRYEALRLLCDATSNASSVLRSLGYPADAFLAAERCRDAADAAGDPVLQGHAAYILARAATACGSYQRGQTIAERAIDDLGRHIARPGGPEALGSLHLVAALASRCRERLDDSREWLDEAAELAQRTGETDTMGMFFGPTNVDIWRMSIEVDDGDPGRVVEIAQRTDPATIPAGVRQVFYYADTARALARIGGRDREAIRFLLTAERIAPQHVHTSAELAETTRALLDRSRRQAGGSELRGLSERMQVSS

Crispr_ID: NC_022657_1

• CRISPR_ID: NC_022657_1
• CRISPR_location: 71084-71242
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_022657_1

Consensus_repeat	Method
GCAGCCGTCTCGGGCCGCGCAAA	CRISPRCasFinder

spacers of NC_022657_1

>1.1|71107|55|NC_022657|CRISPRCasFinder
GCCGGAGGCGGATCGACCGGGATCAGCCGGGCGGGCCGAACCCACCATGGGCTGA
>1.2|71185|34|NC_022657|CRISPRCasFinder
ACCGTTCGCACTCTGCGGTCGCGCAAACTCCGAA

CRISPR arrays and Neighbor proteins around NC_022657_1

CRISPR arrays

The CRISPR arrays of NC_022657_1

>merge|NC_022657|1|71084-71242|CRISPRCasFinder
ACGTCGCCCGCGGGCCGCGCAAAGCCGGAGGCGGATCGACCGGGATCAGCCGGGCGGGCCGAACCCACCATGGGCTGAGCGGCACCTGCAGGCCGCGCAAAACCGTTCGCACTCTGCGGTCGCGCAAACTCCGAAGCGTCCGCGTCAGGCCGCGCGTAA

>NC_022657|1|1|71084-71242|CRISPRCasFinder
ACGTCGCCCGCGGGCCGCGCAAA	GCCGGAGGCGGATCGACCGGGATCAGCCGGGCGGGCCGAACCCACCATGGGCTGA
GCGGCACCTGCAGGCCGCGCAAA	ACCGTTCGCACTCTGCGGTCGCGCAAACTCCGAA
GCGTCCGCGTCAGGCCGCGCGTAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023357298.1|73756_75898_+|(Fe-S)-binding-protein	unknown	unknown	gnl|CDD|223325
NC_022657.1|WP_041840477.1|72317_73127_-|DUF881-domain-containing-protein	unknown	unknown	gnl|CDD|377575
NC_022657.1|WP_041841620.1|69120_69951_-|class-E-sortase	unknown	unknown	gnl|CDD|320679
NC_022657.1|WP_041840478.1|81375_82584_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|376540
NC_022657.1|WP_041840476.1|61924_63424_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl|CDD|223843
NC_022657.1|WP_023357292.1|66312_68106_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl|CDD|270916
NC_022657.1|WP_023357293.1|68165_68816_-|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl|CDD|181107
NC_022657.1|WP_148307827.1|80558_81386_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023357288.1|60464_61892_+|protein-phosphatase-2C-domain-containing-protein	unknown	unknown	gnl|CDD|223704
NC_022657.1|WP_041840475.1|59194_59980_+|DUF3662-and-FHA-domain-containing-protein	unknown	unknown	gnl|CDD|378850
NC_022657.1|WP_023357297.1|73296_73560_+|cell-division-protein-CrgA	unknown	unknown	gnl|CDD|377706
NC_022657.1|WP_023357290.1|63420_64926_+|penicillin-binding-protein-2	unknown	unknown	gnl|CDD|223839
NC_022657.1|WP_023357299.1|75894_76557_-|GPP34-family-phosphoprotein	unknown	unknown	gnl|CDD|377552
NC_022657.1|WP_023357294.1|68824_69109_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023357300.1|76658_77993_+|HlyC/CorC-family-transporter	unknown	unknown	gnl|CDD|224173
NC_022657.1|WP_023357287.1|59985_60468_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|224630
NC_022657.1|WP_023357303.1|80040_80562_+|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|132028
NC_022657.1|WP_023357291.1|64927_66316_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NC_022657.1|WP_023357302.1|79076_79961_+|hypothetical-protein	unknown	unknown	gnl|CDD|214598
NC_022657.1|WP_041841621.1|77985_79011_+|HlyC/CorC-family-transporter	unknown	unknown	gnl|CDD|224173

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023357298.1|73756_75898_+|(Fe-S)-binding-protein	gnl|CDD|223325	COG0247, GlpC, Fe-S oxidoreductase [Energy production and conversion].	5.42988e-84
NC_022657.1|WP_041840477.1|72317_73127_-|DUF881-domain-containing-protein	gnl|CDD|377575	pfam05949, DUF881, Bacterial protein of unknown function (DUF881). This family consists of a series of hypothetical bacterial proteins. One of the family members YlxW from Bacillus subtilis is thought to be involved in cell division and sporulation.	1.25994e-50
NC_022657.1|WP_041841620.1|69120_69951_-|class-E-sortase	gnl|CDD|320679	cd05830, Sortase_E, Sortase domain found in the class E family of sortases. Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	7.63306e-63
NC_022657.1|WP_041840478.1|81375_82584_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	1.33064e-06
NC_022657.1|WP_041840476.1|61924_63424_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl|CDD|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	3.08563e-74
NC_022657.1|WP_023357292.1|66312_68106_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.6289e-125
NC_022657.1|WP_023357293.1|68165_68816_-|aminodeoxychorismate/anthranilate-synthase-component-II	gnl|CDD|181107	PRK07765, PRK07765, aminodeoxychorismate/anthranilate synthase component II.	2.79034e-139
NC_022657.1|WP_023357288.1|60464_61892_+|protein-phosphatase-2C-domain-containing-protein	gnl|CDD|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	3.15842e-73
NC_022657.1|WP_041840475.1|59194_59980_+|DUF3662-and-FHA-domain-containing-protein	gnl|CDD|378850	pfam12401, DUF3662, Protein of unknown function (DUF2662). This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with pfam00498.	6.32554e-50
NC_022657.1|WP_023357297.1|73296_73560_+|cell-division-protein-CrgA	gnl|CDD|377706	pfam06781, CrgA, Cell division protein CrgA. CrgA is a trans-membrane (TM) protein, first described in Streptomyces as being required for sporulation through the coordination of several aspects of reproductive growth. In Mtb (Mycobacterium tuberculosis ) CrgA is a central component of the divisome, and consists of 93 residues with two predicted TM helices (TM1: residues 29-51; and TM2: residues 66-88). CrgA facilitates the recruitment of the proteins essential for peptidoglycan synthesis to the divisome and also stabilizes the divisome. Reduced production of CrgA results in elongated cells and reduced growth rate, and loss of CrgA impairs peptidoglycan synthesis. CrgA has homologs in other actinomycetes.	5.42644e-33
NC_022657.1|WP_023357290.1|63420_64926_+|penicillin-binding-protein-2	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	1.17438e-78
NC_022657.1|WP_023357299.1|75894_76557_-|GPP34-family-phosphoprotein	gnl|CDD|377552	pfam05719, GPP34, Golgi phosphoprotein 3 (GPP34). This family consists of several eukaryotic GPP34 like proteins. GPP34 localizes to the Golgi complex and is conserved from yeast to humans. The cytosolic-ally exposed location of GPP34 predict a role for a novel coat protein in Golgi trafficking.	1.3837e-47
NC_022657.1|WP_023357300.1|76658_77993_+|HlyC/CorC-family-transporter	gnl|CDD|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.55185e-129
NC_022657.1|WP_023357287.1|59985_60468_+|FHA-domain-containing-protein	gnl|CDD|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	1.31532e-19
NC_022657.1|WP_023357303.1|80040_80562_+|SigE-family-RNA-polymerase-sigma-factor	gnl|CDD|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	3.81167e-41
NC_022657.1|WP_023357291.1|64927_66316_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.72795e-115
NC_022657.1|WP_023357302.1|79076_79961_+|hypothetical-protein	gnl|CDD|214598	smart00282, LamG, Laminin G domain.	1.13907e-07
NC_022657.1|WP_041841621.1|77985_79011_+|HlyC/CorC-family-transporter	gnl|CDD|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.40837e-65

Protein sequences

>NC_022657.1|WP_041841620.1|69120_69951_-|class-E-sortase
MAAEPDAGAGGDEGDKPRRGEKVVKLRPEQTDEGYKSVYSELTRPTLGSRIRAGVRVSGELMITFGLIVLLFAGYEVFGNSAKVENEQDTLANQLDDQWNDPTVAPSAGPTKAAPAAPGKNLVGRLYIPKLGMEWVVVNGVRPQDIRYAPGHYPDTADPGKVGNFSVAGHRIRKIFWRLDELQPGDVIGVETRTNWYVYKVSRSEVVKPSAVEVVAPVPGKPNAKPTKAMLTLTTCNPKFNNYQRLIVHAELVDTVKRDASQPEAGKPAEMKKTKA
>NC_022657.1|WP_023357294.1|68824_69109_-|hypothetical-protein
MYAWIWRKLPFGLWGKLTGSLAMAAAIGALLWYVVFPWATPLLPFDDVQVGTGTEQGGPAEQDPNAVPGADDPGLGPDEIPYNEHTNDPEPTAS
>NC_022657.1|WP_023357293.1|68165_68816_-|aminodeoxychorismate/anthranilate-synthase-component-II
MRILVIDNYDSFVFNLVQYLGQLGAECEVRRNDEITVADVADFGAAGVLLSPGPGTPERAGIMMDVITAYAGKIPMFGVCLGHQAIGAAFGGTVTRAPELLHGKTSSVQHKGAGVLAGLPDPFTATRYHSLAVLPETLPEELEVTGWTESGVVMAMRHRTLPIEGVQFHPESVLTEGGHTMLANWLASCGLPEALDRAPELAAEVETRRRSAFAGA
>NC_022657.1|WP_023357292.1|66312_68106_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MTAQARLLGGRYQVGELLGYGGMAEVHKGRDLRLGRDVAIKMLRTDLARDATFQERFRREAQNSAALNHPAIVAVYDTGEEVSSAGEKQPFIVMEFVNGRTLKEVLAAEQRLQQRRALEIIADIDAALEFSHRHGIIHRDIKPGNVMITQNGQVKVMDFGIARALASGATTMTQTSAVIGTAQYLSPEQARGESVDARSDVYAAGCVLFELLVGHPPFVGDSPVSVAYQHVREDPKAPSDINREVSPDVDAIVLKALAKNPLNRYQSAQEMRADALRAVSGRPVLATPVMNEAETMAMAGPPMRQQTAMTRTIPAGGPRGPQPPERKTSSWVMAVLAALGVLAVVALGIGLTLANRNDDPETPATAAVPKVTGLSENDARKTLTDAGFTAVTVGDPIETDDCKDRVERQTPEANATTRVDQAVTLQLCSSPAPTKVPTGLVGSTRDAAESALEDAKLKPKFVEKDSSAPEGQVLSVEDEGDEVKRGTTITVTVSRGNLSPVPDVRGKLQDTAIALLEQAGFKDVKVQETNQEGPVGTVVEQTFANQKKSKSTTITITVIVAQEPEPGDSTDPTDPTDPTDGPGAGGDGGGLDGIIGN
>NC_022657.1|WP_023357291.1|64927_66316_+|serine/threonine-protein-kinase
MISPGVTLGGRYRLDERIAGGGMGDVWRGTDEVLGRTVAVKILLPALLDEPGFAERFRGEARTMATINHPGVVDVYDYGSDQQLAFLVMEYVEGDALSRTLSRVGRLTPARTMALVAQAADALQAAHANGIVHRDVKPGNLLVRPNGTLVLTDFGIARSAMVGQLTVAGSVLGTASYISPEQASGAVATAASDVYALGVVAYQCLSGHRPFDGSTPIEIAMKHVRDTPRPLPADIPQAVRAIVDRALAKDPGARWPTASAMAAVARQAASSLTTQVQQPAVNGSSAGRPQSGGPTMTRPQSSGPSMANRPHSGAPTSGPGGHPMSGQGRPPYPPIPRPVSGAQARGAASVPPAQQPYRHPSAPPMQQHQPMQGGKQADGSGGRQVLIVLAVVLALLVLLCAGVISFLLNQGNTNAMGDHGNRSTVVVAGSADQRTSATSYRLTKQAAAPHSLNHATEGRQTL
>NC_022657.1|WP_023357290.1|63420_64926_+|penicillin-binding-protein-2
MNAPLRKAGVVILVLFGMLFANLNWVQAYKADDYRTSDYNGRVRVAEYETPRGVIEAGGEALAQSKATDDTLKYLRVYPEKKVYAPIIGYKPVDNAETGIERSENDFLSGASDKLFADRVSAMFTGDKAGGGNVVLSVKPKAQEVAYKQLTNNERGAKAGSAVAIDPRTGAIQALASFPTFDPNPLVSHDNKVATAAFKDLNADKDKPLLNRALSETYPPGSTFKVIISAAALQDGYEQSTEIPAGQTYTAPGSGAPIKNSEDQTCPGAQVTLKEALTDSCNTGYAQLGVKLGGDKVKKAAQAWGFEQNDLTVGNLQEGTGLPVAASKTGEIKNPDGSTDQAGLAQSSIGQKDVRMTTMEGALMAATVANGGKQMRPYLVQQLLSPDRRPIYNASPQTLRTPVNGQVASDLKDMMVSVVENGTGQRAKIDGYEVGGKTGTAQNAVDADDHGWFIGFAYNDKGEAVSAVCVMLENVPGGHASAEAARIAGLIMKAAAGRGGD
>NC_022657.1|WP_041840476.1|61924_63424_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MTAPAIPAPTPASTGEMPRVPGTKTGRNAELGLLAFAMVIVAAYGATVEANQYDKITPTFWVPAALLSVLFLGLHLVVRFVAPHADPVLIPAVALINGLGVGFLRRLDIAKAISEKQPELGVFAGVGGRQLAWTLVALVLAAVLLLIVRDHKTVSRYAYTLGLVGIVLVMIPAVLPSSISEVNGAKLWIKMGAFSIQPGEFAKLALVSFFAYYLVRKREVLSLASRRFLGIDFPRGRDLGPVVTVWLLSLLVLVFEKDLGTALLYFGLFVVTLYVATERASWLIIGLVMFFGGVYVAYLLGASIGGPFANFYDRATVWLDPFASENYERIGGSYQLVQGLLGLGTGGMFGTGPGAGSPGFVPEVRNDFIFAGMGEEIGLFGLSALLVCYLLIVERGLRAALGVRDSFGKLVAGGLAFTLGLQVFVILGGITGLIPLTGQTTPFLSSGGSSLMANWLLIAMLLRISDAARKPANGGPAASGGPKQPPAQLHGAMTEVIKP
>NC_022657.1|WP_023357288.1|60464_61892_+|protein-phosphatase-2C-domain-containing-protein
MTLTLRYAAQSDRGLIRDGNQDSVYAGPRLLAVADGMGGMAAGDVASNIVIAAMAPLDEDVPGDALVDALRHAVGTANQTLRDTVDANPHLEGMGTTLTAVLFSGSKIGMVHIGDSRAYMLRQGEFSQITKDDTYVQMLVDEGRISPEEASSHPQRSLLTRALDGRDIDPEYSVRQVLKGDRYLICSDGLSGVVSAETIGESMRDIQDAQACCERLVQLALRGGGPDNITVVVADATDADIMEQAPIVGGAAARDRGNSTVADASSAAARAAALQAPPRPAAPENTSYDRDEADQPKRHPVRTSLLVLLLLGVLGGGLYLGWQYTQDQYYVGATEQGQLAIFRGVPGQIAGLDLSSVHETSEARLDDLTTVAQDRVKQGIHADSNPDAQRRLAELTSDEPSNPNLKPICSPSSPAPTVTQPVNPSGAPSAAGKTTSPSRNTPSSAPALAPATTPDAQPSDSAPPVVDPVGCRPVD
>NC_022657.1|WP_023357287.1|59985_60468_+|FHA-domain-containing-protein
MPEFVLTVARFGFLILLWIFVFTVVGVIRKDLFAGVRSKSIVASPRGVGGAVIQGRPAKAKRGKAARQLVVTAGQLAGTRITLGEAQITIGRAEDSTLVITDDFASARHARLVPRDGQWFVEDLGSTNGTYLDRGKVSGPTPVPLGVPIRIGRTSLELRP
>NC_022657.1|WP_041840475.1|59194_59980_+|DUF3662-and-FHA-domain-containing-protein
MSSEPEEEPVSVLQRFEKRLEGLVEGAFAKVFKGVVHPVEILNAMQREAEAHKAILAGGRTLVPNRYVIDLSPYDHSRLAPYAAALAQELAQSQAEFIGEQAWTVYGDVIVEIERGDGLDTGMFRVTAEVYTGGEVAPVQQPAYDAAPAYSPYDQQQQGGYQQHGHNGRNVGLVSGDGRTYPLQMGSTVIGRGDQANLRLPDVGISRRHARLDYDGSQVVLTDLGSTNGTMVNGQRVSAVALNPGDMIQLGTTTLTFRVDG
>NC_022657.1|WP_041840477.1|72317_73127_-|DUF881-domain-containing-protein
MEYTTGAPSWRLVLRRALGGLRPRRPGQRQRGWSIAVPLIGLAAGLLFTTSATTADGTSLRDDRRPQLAQLIADKRTRLDGREKRAADLRAAVDQDAAKLADVDEPVKSARARADAMRGGAGFTALRGPGITVSLNDSPQRITGTGVDAPENDDLVVHQGDVQAVVNALWAGGAEAMSIMDVRVISTSAVRCVGNTLLLHGQVFSPPFKITAIGEPTAMHRALESAEGVQQFRTAVADFGLGYQETVERNVTVRAYDGSSDLRSAEVTE
>NC_022657.1|WP_023357297.1|73296_73560_+|cell-division-protein-CrgA
MPKSQVRKKKVYTPPTDIRPAAAAASKKPSPVWLPITAVALIVFGISWLVVYYLSEQQYPVEAWRYWNLLVGFGCMVASLGILSRWR
>NC_022657.1|WP_023357298.1|73756_75898_+|(Fe-S)-binding-protein
MGTAQIIATVLAAAVTIVAVALAVRAVMQMTAVIRQGKPDPERFGDKGARTKTMLVETAGHTRMLKWGVVGAAHWFVMVAFVVLSLLVLEAYFEVVSPELGLPVIGHWVVFGLATEWIGVLGTIGILVLVAIRQRDKRKKVSRFTGSTMWQAYFVEAIIIAVLICGFLIRGFKVATDHFEYPFWATPVSHGIGALLPDWENGATWTALVKILISMSWLITISLNVTMGVAWHRFLAFFNIYFKRSPKKPAGSGMGALRPMMSQGKPLDFEEADPEKDQFGVAQVEQFTWKGLLDFSTCTECGRCQSQCPAWNTAKPLSPKLMILSLRDHAYAKAPYLLGGGGKDLTGEEKATEAQLAHMDVLALAEGNRPLIGTEEEQGVIDPDVLWSCTTCGACVEQCPVDIEHIDHIVDMRRYQVLIESSFPSEAGVMLRNLENKGNPWGAPQNTREDWTKGLDFEIKRVGEEEFDYLFWVGCAGAFEDRAKKTTRAVATLLHEAGVDFAILGEGETCTGDPARRIGNEFVFQMLAQQNVETLQEAKVKRIVATCPHCFNTLGNEYEQLGLKVEVVHHTQLLAHLVAEGKLTPVQPVDGGVTYHDPCYLGRHNRVFEAPREVLGSAIEGGLTEMPRNSERSFCCGAGGARMWMEEKIGKRINVERTEEALATGAKTIAVGCPFCYTMIGDGVTGKGEQENVEVIDVASVLLRSIKGDKAPA
>NC_022657.1|WP_023357299.1|75894_76557_-|GPP34-family-phosphoprotein
MNLAEEFALLAYGDDGAPDTDTMRLDNGLGGALLLELALTGRVDVEDKKVIVRDGTPTGDPLVDQALERIVADDKQRKPGQWVTKFAKDARKLTLDRLVSQEVLVREQDKVLLVFPRTRYPAPHGGRPIPETEARQRLTAAVTRTEAVEPRTAALCALVAATDLDRKVFRDLDRNLVKTRLKEISQGAWAADAVKKAIEEIQLAIIMTVVAATSATATTS
>NC_022657.1|WP_023357300.1|76658_77993_+|HlyC/CorC-family-transporter
MDGLFLSAVLPLAAFALLTAGNAFFVAAEFGLVTVDRVEIAKQAEAGDRRARTVQNALHELSFQLSGTQLGITLTALLTGYLAEPALSRLFRPAIEPLFGGATETVTHVLSLVFATLVSMLFGELVPKNAALARPMRVALATAAPLRTFSKLFKWLISALNGSANWLVRRLGIEPQEELASARSPEELGLLAAISARAGALPTETATLLRRTIRFGEKRAAKAMTPRVDVVGLKTTASVADLIATSRQTGHTRFPVYESTLDLVVGVVGISDALGVPPERRAATPVSSVAREPVLVPESLDLDKVLAALRAADADLAIVVDEYGGTDGVVTVEDLIEELVGEIADEYDLDFTEAGSVELTAPDGDKTYLVDGLLREDEVAEQTGFRLPEGPYETLAGFLLSRLGHIPVAGESLEDDGWEFTVMEVDRHRIEQVRVVAPPEPADD
>NC_022657.1|WP_041841621.1|77985_79011_+|HlyC/CorC-family-transporter
MTELLVTVVLLLGNALFVGGEFALIASRRTALEPLAATSRRARWALSAMNQIPLMIAGAQLGITICSLGLGAIAEPALAHLVEGPFEAIGMPERAVHPVAFVLALGVVVFLHTVVGEMVPKNITLAGPERSALVLGPFMLAFCTATKPILTAMRWAAKIVLSLWKVEATDAVKTVFTAEELAGMVTQARAEGLLGTEQYARIHAALGLNVRTAADTLQPWSGVTTVADDASPATIEAIATRSGRSRFPVVQRETRRVLGFVHVKDILGYEGAQRRLPIPAEIIRPLAVVPPERTLADLLLTMRRDRRHIVLVSDGRRPLGVIALDDVLHAVVGEPSVRSVV
>NC_022657.1|WP_023357302.1|79076_79961_+|hypothetical-protein
MFDNRRSSRSARPRVSPFGVLVAAAALGAGLLAVTQFTPKPHISPQYVALQPRPSAGVLTGVTSGFAAHQQRGGAGQVGIAAAPVAVRYTFDGGIHQPITDLGGAYALRPLAQNGGTLRLVPQGKGLAVKYPARCTLTRERRCPRAILEGLRDDRLNPGTRPMQYGASVLMTHADLSDGANVFQKGYSVGGVSQFKLQVDHKQGHPSCVIAGRARIYRAEPFMDVADGRWHNLMCARSRNRLTMVVDGVERASVPVPATLSIANAEPLRVGGKGPNKGNDQFAGQIDNVYLTIN
>NC_022657.1|WP_023357303.1|80040_80562_+|SigE-family-RNA-polymerase-sigma-factor
MVRSRRFDGLDTLIAERGNALLGTAVLLTGNRAAGEDLLQAALERLMRSWGRVREDRERYLRRTMYHLAIDQWRHRRRRPEVFLGHEPPGGPDATDALDLRDALIMALAQLSPRQRAVLVLRYWEQLTEPETAAELGCSVGTVKSTASRGLARLRELTSTWDLHHATLNGTGR
>NC_022657.1|WP_148307827.1|80558_81386_+|hypothetical-protein
MTTELEARLTESMHHQVDGLALSTDILDRATRRHQRRTTTIRIGYALGAAGLAGALAAGLSLGGGAAEPPAVVQAAPASMRLANAATASDNISYRIHLKSGSRVGDGAFDPRTASGYFRVPQDDSVTTEIMVNGTRYIGGEPPLGKLPADKGRGEKYGRYGQYPGKHKSLSLFGNGDAVVGAAAPNPAALFKALSQANATTSENPDGTFHFEYATTTGDVALNSDGRIARMTLTTTWRSTAKGRLDTGRFDTTIELSDYGLKVKVKRPADVVPTS
>NC_022657.1|WP_041840478.1|81375_82584_-|helix-turn-helix-transcriptional-regulator
MTPRRSGDTSVGGLIRARRLLRGWSVRYAASRAGVSHATWSRIERGLQAADNRFMVADIAGALECSPADLVSTEVPAPDRVTKAARARVLGLRRALIDIDLSEAPAGAALPMVELSRGVALVDALHQACDYAGAARLLPGLLSDLHTETAGPDRYEALRLLCDATSNASSVLRSLGYPADAFLAAERCRDAADAAGDPVLQGHAAYILARAATACGSYQRGQTIAERAIDDLGRHIARPGGPEALGSLHLVAALASRCRERLDDSREWLDEAAELAQRTGETDTMGMFFGPTNVDIWRMSIEVDDGDPGRVVEIAQRTDPATIPAGVRQVFYYADTARALARIGGRDREAIRFLLTAERIAPQHVHTSAELAETTRALLDRSRRQAGGSELRGLSERMQVSS

Crispr_ID: NC_022657_3

• CRISPR_ID: NC_022657_3
• CRISPR_location: 249205-249282
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_022657_3

Consensus_repeat	Method
CGAGCTGGAGGAGACCAACCGCGG	CRISPRCasFinder

spacers of NC_022657_3

>3.1|249229|30|NC_022657|CRISPRCasFinder
TGTGATGGCTCTGTACCACCAGCTGTCCGA

CRISPR arrays and Neighbor proteins around NC_022657_3

CRISPR arrays

The CRISPR arrays of NC_022657_3

>merge|NC_022657|3|249205-249282|CRISPRCasFinder
CGAGCTGGAGGAGACCAACCGCGGTGTGATGGCTCTGTACCACCAGCTGTCCGACGAGCTGGAGGAGACCAACCGCGG

>NC_022657|3|3|249205-249282|CRISPRCasFinder
CGAGCTGGAGGAGACCAACCGCGG	TGTGATGGCTCTGTACCACCAGCTGTCCGA
CGAGCTGGAGGAGACCAACCGCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023357482.1|252820_254341_+|FtsX-like-permease-family-protein	unknown	unknown	unknown
NC_022657.1|WP_148307840.1|261549_264591_-|glycosyltransferase	unknown	unknown	gnl|CDD|340831
NC_022657.1|WP_023357469.1|243092_243731_+|CGNR-zinc-finger-domain-containing-protein	unknown	unknown	gnl|CDD|378696
NC_022657.1|WP_041841653.1|257863_258478_-|dihydrofolate-reductase-family-protein	unknown	unknown	gnl|CDD|223340
NC_022657.1|WP_148308244.1|247257_247650_+|anti-sigma-regulatory-factor	unknown	unknown	gnl|CDD|340411
NC_022657.1|WP_023357471.1|244537_244771_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023357487.1|259045_261553_-|glycosyltransferase	unknown	unknown	gnl|CDD|340831
NC_022657.1|WP_052359620.1|254387_256463_-|S9-family-peptidase	unknown	unknown	gnl|CDD|224684
NC_022657.1|WP_023357484.1|256603_257776_+|FAD-binding-oxidoreductase	unknown	unknown	gnl|CDD|223354
NC_022657.1|WP_023357486.1|258519_259083_-|dihydrofolate-reductase	unknown	unknown	gnl|CDD|223340
NC_022657.1|WP_023357473.1|245398_245752_-|anti-sigma-factor-antagonist	unknown	unknown	gnl|CDD|273042
NC_022657.1|WP_023357480.1|251601_252138_+|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NC_022657.1|WP_023357479.1|250017_251568_+|fused-response-regulator/phosphatase	unknown	unknown	gnl|CDD|369272
NC_022657.1|WP_023357472.1|244831_245275_-|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl|CDD|376605
NC_022657.1|WP_023357468.1|241596_242862_-|ThuA-domain-containing-protein	unknown	unknown	gnl|CDD|377643
NC_022657.1|WP_041841652.1|247646_248678_+|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|340411
NC_022657.1|WP_023357470.1|243773_244541_+|zf-HC2-domain-containing-protein	unknown	unknown	gnl|CDD|227947
NC_022657.1|WP_041840503.1|246823_247234_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132912
NC_022657.1|WP_023357474.1|245952_246819_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132912
NC_022657.1|WP_023357481.1|252134_252824_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_148307840.1|261549_264591_-|glycosyltransferase	gnl|CDD|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.22901e-43
NC_022657.1|WP_023357469.1|243092_243731_+|CGNR-zinc-finger-domain-containing-protein	gnl|CDD|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	1.40728e-14
NC_022657.1|WP_041841653.1|257863_258478_-|dihydrofolate-reductase-family-protein	gnl|CDD|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	5.63935e-17
NC_022657.1|WP_148308244.1|247257_247650_+|anti-sigma-regulatory-factor	gnl|CDD|340411	cd16934, HATPase_RsbT-like, Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains. This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.	6.2127e-37
NC_022657.1|WP_023357487.1|259045_261553_-|glycosyltransferase	gnl|CDD|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.8418e-45
NC_022657.1|WP_052359620.1|254387_256463_-|S9-family-peptidase	gnl|CDD|224684	COG1770, PtrB, Protease II [Amino acid transport and metabolism].	0
NC_022657.1|WP_023357484.1|256603_257776_+|FAD-binding-oxidoreductase	gnl|CDD|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	5.18457e-26
NC_022657.1|WP_023357486.1|258519_259083_-|dihydrofolate-reductase	gnl|CDD|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	9.40361e-22
NC_022657.1|WP_023357473.1|245398_245752_-|anti-sigma-factor-antagonist	gnl|CDD|273042	TIGR00377, Anti-sigma_F_factor_antagonist, anti-anti-sigma factor. This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions].	1.08587e-29
NC_022657.1|WP_023357480.1|251601_252138_+|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.55198e-17
NC_022657.1|WP_023357479.1|250017_251568_+|fused-response-regulator/phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	5.12643e-44
NC_022657.1|WP_023357472.1|244831_245275_-|large-conductance-mechanosensitive-channel-protein-MscL	gnl|CDD|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	5.54666e-50
NC_022657.1|WP_023357468.1|241596_242862_-|ThuA-domain-containing-protein	gnl|CDD|377643	pfam06283, ThuA, Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.	1.88956e-38
NC_022657.1|WP_041841652.1|247646_248678_+|SpoIIE-family-protein-phosphatase	gnl|CDD|340411	cd16934, HATPase_RsbT-like, Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains. This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.	3.30924e-27
NC_022657.1|WP_023357470.1|243773_244541_+|zf-HC2-domain-containing-protein	gnl|CDD|227947	COG5660, COG5660, Predicted integral membrane protein [Function unknown].	4.48679e-21
NC_022657.1|WP_041840503.1|246823_247234_+|STAS-domain-containing-protein	gnl|CDD|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	3.84105e-30
NC_022657.1|WP_023357474.1|245952_246819_+|STAS-domain-containing-protein	gnl|CDD|132912	cd07041, STAS_RsbR_RsbS_like, Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation. The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.	6.18177e-43
NC_022657.1|WP_023357481.1|252134_252824_+|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.34022e-93

Protein sequences

>NC_022657.1|WP_041841652.1|247646_248678_+|SpoIIE-family-protein-phosphatase
MSGGAVASLPEGLLDAGVWFRVEAAGTAAAVRRAAERLATELGLPANRIADLSIVAAETAGNLVKHADEGMLLVRPVRVPDRAGVEIVALDRGPGMADIARSLGDGHSTAGTLGIGLGAIVRQASWSDLHSVPGRGTVMSIQVWADEAPPPAWAAGLTRPLTGETVTGDGFAIREADGRRQVLVCDGLGHGHLAHAATQEAVRVFDSTAAAPPAVVVEALHRAIGHTRGAALAVAELDDRAGLVRYAGLGNIAGIVVGADGTRRGMVSLPGIAGHQRRQIREYDYPLLPGAVVIMHTDGIVDRWNATDYPGLITHSPQVIAATVLRDAGTRRDDAGVLVARTP
>NC_022657.1|WP_148308244.1|247257_247650_+|anti-sigma-regulatory-factor
MERIVVRTDQDVVRVRQLVRTLAVAVKLSLVDQTKLVTAASELARNTLVYGGGGTVDVGRVDNGRRLGIKIVFADEGPGIADLSLALTDGYTTGGGLGLGLSGARRLVDEFDIDTRVGQGTTISVIKWCR
>NC_022657.1|WP_041840503.1|246823_247234_+|STAS-domain-containing-protein
MERVPVLKIGDILLVSIQIDMEDQVALQLQEDLADRIVATGCHGVIIDISALDIVDSFVGRTLATIASVSRVLDAETVVVGMRPAVAITLVELGLSLPGIQTALNVELGIEMLARDRDFELPLDEDDAGEAVVSTP
>NC_022657.1|WP_023357474.1|245952_246819_+|STAS-domain-containing-protein
MALSTEEVGRFAGLLESNAEAVITAWTDAVSTLLRGRLSHAELRRQIADLHKGFHAALAGGATDLEGDSAAELRAQLSELSTIRARQGFTATETAVSVFALKDAVLPFFEQGASADATTLRDYVAFSAFIDRAGLFTFDSYVRAREDLISDQAEQLLELSTPVVKLWEGVVAVPLVGTLDSARAQVVMERLLQTLVDTGSPYAIIDITGVPAVDTQVAQHILKTVVAARLMGADCIISGIRPQIAQTIVALGIEFGDIATKASLADALRHVLRKTDAKALGRAGRREG
>NC_022657.1|WP_023357473.1|245398_245752_-|anti-sigma-factor-antagonist
MSLTVQTEQRGDVVVVSVAGELDMATAPQLQDQISDLLEKGRTRLVFDLADVSFCDSTGLSVFVRAKNSTDDAGGVVRLAAPQRGVLRILEVSGLVEVLHTYPTVDEAVTAEEPALD
>NC_022657.1|WP_023357472.1|244831_245275_-|large-conductance-mechanosensitive-channel-protein-MscL
MLKGFKDFIMRGNVVDLAVGIVIGAAFTAVVSGFTKSFLEPLIKWISGGSGVGAGVWEPSEGIQFTYAAFINSVITFILTAAVLYFLVVYPLNRLAERRKRGEEPPPEAPSEEVKLLTEIRDALVRQQVTPGAANDILGRHQEPGQR
>NC_022657.1|WP_023357471.1|244537_244771_-|hypothetical-protein
MEQRKHWWNGRWGRVARKDVYLRTSGDQWYVEQRAGGSDGVSHFFEYDSEEAALDMVRALLVGPDEWRELSVRPPAR
>NC_022657.1|WP_023357470.1|243773_244541_+|zf-HC2-domain-containing-protein
MACERWREMLSAQLDGEDDPADRARVDEHLAGCAGCRQWLERAATVNRLTRTGLVADVPDLSAAILAALPAAPERKRRRLGVGPLYVALAAVGAVQLILGLAQVGGGASSLHVHTGLDATPGHLWHESAAWNVAVGAGFLFIALRRSRPTGLVPMLTAFVGMLLLLSVNDLSAARVDAERLISHGFVILGYLLVVALSRVTRETVRPPGDRSTGGKAWHFVEEEEVADPVLPKLRLVPRGPLTASAADYEERRAA
>NC_022657.1|WP_023357469.1|243092_243731_+|CGNR-zinc-finger-domain-containing-protein
MSWKASARHGVREAPAGLALLQDLLNTRASMSYAPDLLGTPDDAQRWLTDALGTWARVAGLPAPVILLSSTDMRSLRRLRTTFEGVILAGGRSPEPDGALPPADVPVSLVPDADGWVRMVPSGRGIRWLASALWAEALLAQQAGLWPRLKLCHNIDCRAAFFDTSRNNSGVWHDVSTCGNTANLRAFRERKRLMGNSGNQLGGPSVQRPDLH
>NC_022657.1|WP_023357468.1|241596_242862_-|ThuA-domain-containing-protein
MARNLLRRVLVAALGILTAGTIGIAVRPADAAAAAPFKVLAFYNGTWDAAHIDFDKEARDWFPRAGAQYGFTWEATTDWSRLNTGNLAQYKVIMFLDDAPPSGQRAAFQQYMQNGGAWMGFHVSAFTTDANSWSWYYNTFLGSGNFATNTWGPTAETLKIENRNHPSTAGLAATIPSAVSEWYSWSRDLRQNPDIDILASVDTSSFPVGSDPNQQWRSGFYPLIWTNKNYKMLYTNFGHNAMNYETNTRTSSTFASAQQNQWLINGLLWLGGATSTPPNTPSWYALSSKNSGKCVDARAAGTTSGTAIQQYACNGSTAQQYQLAPTSDGYVRINNRGNSAQALDVTNVSTADNAPIQTWAYSGGTNQQWQPVAEADGSYHFVNRNSGKCLDVPAASTADGVQLVQYACNGTAAQSFRLTAQ
>NC_022657.1|WP_023357479.1|250017_251568_+|fused-response-regulator/phosphatase
MTPATVLVVDDSATKRYLLVSWLSRAGFTVVEAETGGEALRRLTEADIDLVVLDVKLPDMNGFEVCERIKTDPVYGVLPVIHVSAHAVDVVDRTQGLNRGADAYLVEPIEPDELIATSQAVLRYYRARQRAETLAARMIRLAETTLAINSASTLTGLLQAAADGAHEIFDGPVIVVAETSDGDGLAAVADGHESAVRPWTVEHQEIAVGSTVRNDDPDLWPGVPWPEGESVAVASARLRSDRSPVSVAVPSSSQNPGFPVLRQLAQAVAAAVEAQRSYDEEHRIAVTLQRSLLQSRLPDVPGLELAVRYEPAGAQTEVGGDFYELTMLDGRLLVAIGDVAGHSLHAATVMAELRHAVRAYAVEGHPPGAVLELVNRFMRAVLPTESATLCLLTLEPDTGRVRLASAGHLPPLLHVDGKARFLAPKGPLLGINAPRPADLEFVLPPGGTLVLYTDGLIERRDADIDVGLSALADCAAEVDRSLDAFCQRLLVDLAGADEQADDIAVVALRRSVTERA
>NC_022657.1|WP_023357480.1|251601_252138_+|PadR-family-transcriptional-regulator
MSTSHVLLGLLSAGPQHGYELKRVHDERLPRAKPLAYGQVYATLGRLERDGFVEQSGQDQEGGPERTSYTLTDAGRARLDEWLAAVEPPAPYVTSDLFAKVVVSLLASGAAAAKEYLVAQRAAHTTRLRELTAVKTATDSSAGDVVAADYAIAHLDADLRWLQTTLLRVADLHREVIA
>NC_022657.1|WP_023357481.1|252134_252824_+|ABC-transporter-ATP-binding-protein
MSPLLTGTGLHRSYGPTPALRGIDVEIGEGEIVAVTGPSGCGKSTLLHCLAGILKVDSGEVRYRDQDISLWTEAARSRLRRTEFGVLFQFGQLVPELTAAENVALPLLLAGSGRREARKAATMWLGRFGVGDLADQVPGKMSGGQQQRCAVARALVTEPKVLFADEPTGALDVLTGEQVLTEIVHVTREQGTSVVLVTHEPQIAAYADREIALRDGALDPSGLGLGIGS
>NC_022657.1|WP_023357482.1|252820_254341_+|FtsX-like-permease-family-protein
MKPSTLGRLAVAGGRTDVLRMSLTAGSSVLAAVVLLAAATVVAVPELGTSDQGSEAWNDYASPLIAEPGLRPGVVITLLLLAVPVLFLAGQSIRFGSPARDRRLAAMRLAGATPGQAVLIAATETAVASLLGSIVGTAVFLVLQQSLNARNGDGLLYLPSDQLPSVVSFLLVLLLVPVLAGLIGAFLLRRVIITPLGVVRRTRSKAPRLWPGVLILVGIFAPIVIRPLGEWLGHTSGGIGGRLVVLVGFAVVLLAVAGVVIGTGWISYTAGRLLHRFGRRPAALLAGRRLMADPWNGSRTMSALLAALVVGGGVVGYRIYMTTQFAANDAANRLNGTEDGYGDGTDFYLNSVDLIRIAVFAGIVVAAAGIMVAVAEGIVSRRRTNASLVAAGVPRKVLGESLAWQTFAPLVPAVLVALTVGISLLRGIATEASAGGGTTCDGTQAQCADPDSPLWKTYREVTLQVPVPFGDLAVLGGGALVLMLLAVGVGLIFLRRSTELDELRIV
>NC_022657.1|WP_052359620.1|254387_256463_-|S9-family-peptidase
MPTTPPAVRQVPAERTFHGDTVTDEFAWLAEKENPDTIAYLEAENAWTKAATAHLSDLQSTVFEEIKGRTQETDLSVPSRKGGYWYYTRTVEGKQYGIQCRVPAAPDEADPPATGDGAPLPGEEVLLDGNELAEGKNFFALGTFDITPDGDRLAYSVDFDGDERFTLKVKDLRTGEVLADEVPDTFYGSAWSADGSTLFYITVDDAWRPNKVWRHIVGQPASDDVVIFEEADERFWVGVELSRSEKFIIIDANSKVTSEVRVIDASAPTAEPALIRERVQGVEYSIEHHGHRFLILHNENAEDFAVAWTSVDNPGEWVELIPHQPGTRLESVDAFQRHIVISQRRDGLTGLRVMADGSTDSYDMEFPEPIYSVGLAGNPEYDTNVVRISYTSMITPDSVYDVDLITRAMVLRKQKPVLGEFNPDDYEQFREWANAADGTKVPISVVARKGVTRDGTAPLLLYGYGSYEISMDPYFSIARLSLLDRGVVYAIAHVRGGGEMGRRWYEEGKMLAKKNTFTDFVAAAEALVASSWTSADRLVARGGSAGGLLMGAIANIAPEAFAGIVAQVPFVDPLTSILDPSLPLTVTEWEEWGNPLENADVYAYMKSYSPYENVAKLKYPAILAVTSLNDTRVLYHEPAKWVARLRAVAPDGSYLLKTEMGAGHGGPSGRYDAWKEEAFVTAWILGTVGLA
>NC_022657.1|WP_023357484.1|256603_257776_+|FAD-binding-oxidoreductase
MVTALPGREPLLRALIDICGPDFAREAGAADMVAGHLPSFVAAPATTHAAMDTLRLAAERGLAVVPRGSGSKIDWGVPPQGIDMVLDTRRLDGIWDHRPEESTAEIGTGTTIRAVQAALALRGQRLAVDPPSAGATLGGILAVNESGPLRHRFGSPAAQVDSIRYVGRDGVAGESDGEEGRPGIAEVDGVILSAKVRLRPLPAARRWVTVPVSTPLQVHNLVAQILAQRAEPSAIEVDLPTPAGRMISQPPGSVAVLLEGTPADATERAEQVAKSLGDAASVTPTAPRWWGRYPFSRGDVALRISVPIADLHSAVYALRDAAGMPVPVRGSAGSGTVHAVLPGTLTPDRVEGILDAVRGVLLARGGRCVVITAPSPISTNIDMAGRRDLF
>NC_022657.1|WP_041841653.1|257863_258478_-|dihydrofolate-reductase-family-protein
MAKTQYYTATSVDGFTADLDNSLDWLFEVDEGTDNPFGAFFSNVGAFAMGAATYEWVLKNDNVIDEPENWHEMYGDVPCWVFTHRDLPVVPDANVFMVSGDVKRVHEAMMVAAQGRNVWLAGGGDLVGEFADADLLDEIILAVAPAMLGSGTPLLPRRLTSQQMVLTNVAQMGQFAYLSYAVGSLAKLGRHLAADAISREHALR
>NC_022657.1|WP_023357486.1|258519_259083_-|dihydrofolate-reductase
MPKTQFYTATSIDGFIADEDNSLDWLFKADSDPGSNPFTAFFAEVGAFAMGATTYEWVLEHDQLDKEPVKWADYYGDVPAWVFTHRDLPRVPGADLTFVQGDVREVHAAMTERAAGKNIWLVGGGELAGAFADAGLLDELILGVAPVTLGGGAPLLPRRLEAARLTLTGVEQRGQFAYLTYAVGRVE
>NC_022657.1|WP_023357487.1|259045_261553_-|glycosyltransferase
MSAQRGTGALLAATAFTGAANYGLSLILVHLLSPGEFSRFAAVSTLLLTVGTVAGAAVPWVLARETALSGRGDPRRRQAIRFGLIASLVLGVVAATAVVFAAASYSGTGLLLGAAAATVLILLCAVGVGVLQGEQSFLRLAGVRVLEVAIRITLAVLAALVGWGSAGVIGAFAVGAGTAALWSLLAVGRDLWAPSTGTVASETWTLARHAGALAAGQAALSLLLSLDVIIGAAVQAGGDGLAGYQALLVLARVPLFLATALATAVFPRLVSTTGTRTFLPTLRTFLILGAAITAAVASVPAALVEVVLPTEYVASLHLLAPLALAGFGGALATLLVAYLQARERLGAAVAVLTVALVAAGCGYPLAAPDPSTLAWASAVAMLGASAGLLTIIKDTRVVLTAVGPLLLGGAAWLVLHSLTGHLVSWLICAAVVGGAAVLLVRPRPRPEGPLRILHLGFEDPARPGAGGGSVRTHEVNRRIVDSGAEVVVMCSRYPGFAEREQDGVRYVPCGIPVPGGHFPSLLSYFAAVLTGLWQMERRFRPDVIVEDFAAPFSSIAVPYLTRTPVVGVVQWLFAADKTAQYHLPFHLVEALGVKAHDKLIAVSEDLAQELRTRNPAAEVHALPNGLEPAAWQGTAAFGRGDHILFLGRLEIAQKGMDLLLDAYAAAAPYLSSDLHLAGDGPDEAVLRERARRLGIEDRVRWLGRVSGAARFDLLARARLVCMPSRYETFGMVAAEALAVGTPVVAFDIPCLRALVQAEVGVPVPAGDVGALTEALISLANDPARCRRLGAAGPPSVRHLDWDTVAADQLAIYRSVVPLWQGVGRAEDAVLHSDQH
>NC_022657.1|WP_148307840.1|261549_264591_-|glycosyltransferase
MSGLYSSNPWRGRHVVICNWRDSGHPMGGGAELYCERVAAELHADGVRVTYLTARAKGQSKREDTTFGTVVRGGGTYTVYLFVLLWLLLHRRTIDGVIDSQNGIPFFTPLALRRRTPVALLIHHVHQDQFLVHFPQPAARVGQFLENQASSWVYGKRAMAAVSPSSRAEIRRRLSLRGPVHLAPCGQEMPPPRHRRPAPVPRIVCVGRLVTQKRFDVLLRAMPELNRRLPGVELHLVGDGEARPELERLAAELGPAARVRFHGRVDDATRDALVDSAWVTASASMGEGWGLSIMEAAAAGVPAVAFSVPGLRDTIRPGETGWLVEPTGDLPTALADTLVEALRTLVEARASQEWSARCVAWAGRFTWAATAAHLSAVLTAEKNRLATIRVERRPGSDNAALIRLPSALLAGADLTTLRVTDLVEIDQDQAALLLTGADEQDGRRVLARIGVDASHPGVRVRLARHRDLLGWRTHPPTRGAAGERATGLAAVPPPRKRAETLARLAMVPAAVFVLALTVRLIAISRAYDIFVDEISYADVARNLATGQGLVLNGGPFHLHPPGFFLVLAGFFDLFGMPADTASLVLHARPVSAVAGAIVCAGTTLLLVRVVRLPIAATAGVLLAVDPFLLRFDSRVMLEAPAMAAAVVGLVLLTVRPRGHRTAVAWGVVCGLLLASAILTKEWYAFVTAVPLVLLCFSVDRVQRRMRLTALATTVLGYASYVLVMASLGMLPEWWSEKVGGLARAAGVHQATGFNQPGAESFTSRIAANLSTFGASYGLIVIGGMVTAALVVARNRRPWQFLFTAGGGSVVTALGVGAFAFIGYAVTLGTLEEQMFYPVMVTSVMIIAAGLDMALRAQARNGFTIRRRLTGAVAVAAAAVALIGDGSIWAGIRTTPDDTYRQLLAWAPRGFPADSTVAATEDVAQFVLSGVRLGQWSDLPALTSNNVDYVVVSTALAERGYGKARPDFVAALDRGAAVVFSAHGRTMGELRVYDVRKLVGTATARTVAVKAVTR

Crispr_ID: NC_022657_4

• CRISPR_ID: NC_022657_4
• CRISPR_location: 379255-379788
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 13 spacers

Consensus repeat of NC_022657_4

Consensus_repeat	Method
GGCGGTTTTGCGGATCAG	CRT

spacers of NC_022657_4

>4.1|379273|24|NC_022657|CRT
TCCGGTTCGGCTCCCGCTCAGCCG
>4.2|379315|24|NC_022657|CRT
CCTGGTTCCGGCCCCGGTGGCCCC
>4.3|379357|24|NC_022657|CRT
TCCGGTCCCGGCCCCGCTCGTCCC
>4.4|379399|18|NC_022657|CRT
CGCGGTTCGGCCCAGTCG
>4.5|379435|24|NC_022657|CRT
TCCGGCTCGGGTTCCGCGCAGCCT
>4.6|379477|18|NC_022657|CRT
CGCGGTTCGGCCCAGTCG
>4.7|379513|24|NC_022657|CRT
TCCGGGTCGGGTTCCGCGCAGCCT
>4.8|379555|18|NC_022657|CRT
CGCGGTTCGGCCCAGTCG
>4.9|379591|24|NC_022657|CRT
TCCGGGTCGGGTTCCGCGCAGCCT
>4.10|379633|18|NC_022657|CRT
CGCGGTTCGGCCCAGTCG
>4.11|379669|24|NC_022657|CRT
TCCGGGTCGGGTTCCGCGCAGCCC
>4.12|379711|18|NC_022657|CRT
CGCGGTTCCGCCCAGTCG
>4.13|379747|24|NC_022657|CRT
CCCGGGTCGGGTTCCGCGCAGCCC

CRISPR arrays and Neighbor proteins around NC_022657_4

CRISPR arrays

The CRISPR arrays of NC_022657_4

>merge|NC_022657|4|379255-379788|CRT
GGCGGCGGTGCCGACCAGTCCGGTTCGGCTCCCGCTCAGCCGGGCGGTTACGCGGACCAGCCTGGTTCCGGCCCCGGTGGCCCCGGTGGTTACGCGGATCAGTCCGGTCCCGGCCCCGCTCGTCCCGGTGGTTTTGCGGACCAGCGCGGTTCGGCCCAGTCGGGCGGTTTTGCGGATCAGTCCGGCTCGGGTTCCGCGCAGCCTGGCGGTTTTGCGGATCAGCGCGGTTCGGCCCAGTCGGGCGGTTTTGCGGATCAGTCCGGGTCGGGTTCCGCGCAGCCTGGCGGTTTTGCGGATCAGCGCGGTTCGGCCCAGTCGGGCGGTTTTGCGGATCAGTCCGGGTCGGGTTCCGCGCAGCCTGGCGGTTTTGCGGATCAGCGCGGTTCGGCCCAGTCGGGCGGTTTTGCGGATCAGTCCGGGTCGGGTTCCGCGCAGCCCGGTGGTTTTGCGGATCAGCGCGGTTCCGCCCAGTCGGGCGGTTTCGCGGATCAGCCCGGGTCGGGTTCCGCGCAGCCCGGTGGTTACGCGGATCAG

>NC_022657|4|1|379255-379788|CRT
GGCGGCGGTGCCGACCAG	TCCGGTTCGGCTCCCGCTCAGCCG
GGCGGTTACGCGGACCAG	CCTGGTTCCGGCCCCGGTGGCCCC
GGTGGTTACGCGGATCAG	TCCGGTCCCGGCCCCGCTCGTCCC
GGTGGTTTTGCGGACCAG	CGCGGTTCGGCCCAGTCG
GGCGGTTTTGCGGATCAG	TCCGGCTCGGGTTCCGCGCAGCCT
GGCGGTTTTGCGGATCAG	CGCGGTTCGGCCCAGTCG
GGCGGTTTTGCGGATCAG	TCCGGGTCGGGTTCCGCGCAGCCT
GGCGGTTTTGCGGATCAG	CGCGGTTCGGCCCAGTCG
GGCGGTTTTGCGGATCAG	TCCGGGTCGGGTTCCGCGCAGCCT
GGCGGTTTTGCGGATCAG	CGCGGTTCGGCCCAGTCG
GGCGGTTTTGCGGATCAG	TCCGGGTCGGGTTCCGCGCAGCCC
GGTGGTTTTGCGGATCAG	CGCGGTTCCGCCCAGTCG
GGCGGTTTCGCGGATCAG	CCCGGGTCGGGTTCCGCGCAGCCC
GGTGGTTACGCGGATCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023357583.1|374117_374570_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379228
NC_022657.1|WP_041840515.1|369641_370847_-|MFS-transporter	unknown	unknown	gnl|CDD|341042
NC_022657.1|WP_023357582.1|373112_374066_-|EamA-family-transporter-RarD	unknown	unknown	gnl|CDD|225510
NC_022657.1|WP_023357594.1|386536_388921_-|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl|CDD|368494
NC_022657.1|WP_023357593.1|386100_386439_-|hypothetical-protein	unknown	unknown	gnl|CDD|369706
NC_022657.1|WP_162181502.1|379830_381663_+|SseB-family-protein	unknown	unknown	gnl|CDD|223021
NC_022657.1|WP_041840519.1|383543_385928_-|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl|CDD|368494
NC_022657.1|WP_023357584.1|374592_374979_-|phage-holin-family-protein	unknown	unknown	gnl|CDD|377198
NC_022657.1|WP_041840516.1|375097_376948_-|type-VII-secretion-protein-EccE	unknown	unknown	gnl|CDD|274857
NC_022657.1|WP_023357579.1|371000_371795_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|224332
NC_022657.1|WP_023357596.1|391374_392118_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023357595.1|389179_391165_-|acetate--CoA-ligase	unknown	unknown	gnl|CDD|234677
NC_022657.1|WP_023357581.1|372389_373100_+|zf-HC2-domain-containing-protein	unknown	unknown	gnl|CDD|227949
NC_022657.1|WP_041840518.1|382028_382949_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_022657.1|WP_023357580.1|371877_372393_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236605
NC_022657.1|WP_023357587.1|377606_377900_+|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NC_022657.1|WP_023357591.1|382966_383428_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NC_022657.1|WP_023357597.1|392200_392680_+|PH-domain-containing-protein	unknown	unknown	unknown
NC_022657.1|WP_023357586.1|377261_377588_+|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NC_022657.1|WP_041840517.1|381659_382025_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023357583.1|374117_374570_-|GNAT-family-N-acetyltransferase	gnl|CDD|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.00866e-12
NC_022657.1|WP_041840515.1|369641_370847_-|MFS-transporter	gnl|CDD|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.17568e-20
NC_022657.1|WP_023357582.1|373112_374066_-|EamA-family-transporter-RarD	gnl|CDD|225510	COG2962, RarD, Predicted permeases [General function prediction only].	1.37104e-92
NC_022657.1|WP_023357594.1|386536_388921_-|M6-family-metalloprotease-domain-containing-protein	gnl|CDD|368494	pfam05547, Peptidase_M6, Immune inhibitor A peptidase M6. The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.	0
NC_022657.1|WP_023357593.1|386100_386439_-|hypothetical-protein	gnl|CDD|369706	pfam08139, LPAM_1, Prokaryotic membrane lipoprotein lipid attachment site. In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognizes a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached.	0.00223559
NC_022657.1|WP_162181502.1|379830_381663_+|SseB-family-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	4.86105e-10
NC_022657.1|WP_041840519.1|383543_385928_-|M6-family-metalloprotease-domain-containing-protein	gnl|CDD|368494	pfam05547, Peptidase_M6, Immune inhibitor A peptidase M6. The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.	0
NC_022657.1|WP_023357584.1|374592_374979_-|phage-holin-family-protein	gnl|CDD|377198	pfam04020, Phage_holin_4_2, Mycobacterial 4 TMS phage holin, superfamily IV. These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.	3.15409e-17
NC_022657.1|WP_041840516.1|375097_376948_-|type-VII-secretion-protein-EccE	gnl|CDD|274857	TIGR03923, T7SS_EccE, type VII secretion protein EccE. This model represents the transmembrane protein EccB of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccE1, EccE2, etc. This model represents a conserved core region, and many members have 200 or more additional C-terminal residues. [Protein fate, Protein and peptide secretion and trafficking].	2.50987e-22
NC_022657.1|WP_023357579.1|371000_371795_+|helix-turn-helix-domain-containing-protein	gnl|CDD|224332	COG1414, IclR, Transcriptional regulator [Transcription].	2.0085e-25
NC_022657.1|WP_023357595.1|389179_391165_-|acetate--CoA-ligase	gnl|CDD|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NC_022657.1|WP_023357581.1|372389_373100_+|zf-HC2-domain-containing-protein	gnl|CDD|227949	COG5662, COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription].	5.91209e-06
NC_022657.1|WP_041840518.1|382028_382949_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.69254e-27
NC_022657.1|WP_023357580.1|371877_372393_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236605	PRK09645, PRK09645, ECF RNA polymerase sigma factor SigL.	3.38027e-69
NC_022657.1|WP_023357587.1|377606_377900_+|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.19068e-12
NC_022657.1|WP_023357591.1|382966_383428_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00071217
NC_022657.1|WP_023357586.1|377261_377588_+|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	5.93626e-11

Protein sequences

>NC_022657.1|WP_023357587.1|377606_377900_+|WXG100-family-type-VII-secretion-target
MNDGLLKVNFSALAQAGADIQKALNELESQLSQLEADARPLVATWEGKAQTAYALRQQQWTQASTDLKGILRDIKVAVDQSATDYATTEGNAEKRFT
>NC_022657.1|WP_023357586.1|377261_377588_+|WXG100-family-type-VII-secretion-target
MSETQAEAAVMAKTATQFEGVNNSLTSMLNKLMNELSVLQTAWVGSGGKAFETVKVQYQNDLSKLNKALADTAEAIKTSGISYTNTDDSAASMVTKSGGGGYSLPLEN
>NC_022657.1|WP_041840516.1|375097_376948_-|type-VII-secretion-protein-EccE
MAGGRSFPELSGAGQQLPKVRTQRVRHGRLFGIRTGQLVSTQVAAAALLVGAINGPITFAAAAFLAVILLAVTWLRLRGRWAFEWLGTGMHFAGRKHAVPVADAPTALLEFVAPGSRIDQAELGGDPAAVIVDGHGLTAVLELGDPNGLLAEETVTLPSPVGLLPPAGAEHPPCRLQLLLIGAPAPSLRAGGGTPANSYRQLTDGRLLGHSRALLAVRVMRAEGWSEEDLRRALSGLVRKLLRRLNPTPARPLGEAAALRVIAELAHDDGIGIAQETWPGLRVGSLTQATFRLRRWPDLRIETSRRLVARMLTLPAAATTVALGAGPRSATGTDTEIDLTVRLAAPDTASLSVATQALRKLLAGERATARRLDGEHLDGLTATLPLGIPSAPGLPGRPSFDAARADLLDDLQLPISSAGLMIGSNRKGEPVIARLFRPEQTRALLVGGVRCAQLVALRAMALGARVVVQTARPQAWEPFVRGAAVPGEAIAVIPPGRAVEVPPGSALHPLLVVVDIGPVGADNRPGAGWQATLVVRDDFSPADADVASRADLLVVQPLRPEEATLVGAALGLGETAKWLTQIRSDMVGVINRRAVRWATLSQTPIEAQLIGPPVRG
>NC_022657.1|WP_023357584.1|374592_374979_-|phage-holin-family-protein
MGILIRLVITAVSLWIATLLIGGIRLTTDSIGGQIGTLLAVAVIFGIVNAVLRPIIKTIGCGLYVLTLGLISLVINGLLFLLVSWIAGQFDLPFHVDDFWPSAVLGALLVGVVSWVLNMLVPDGGDDD
>NC_022657.1|WP_023357583.1|374117_374570_-|GNAT-family-N-acetyltransferase
MLNERRDDGFVLTDDPERVDHDLVHEWIAGTYWATGRPADVMRRATAGSEPVGIYREADGSQVAFARVVTDGVVFAYLCDVFVDPAWRGRGLGRWLVRALRDDLAARGLRRFLLVTRTAQGVYAPLGFTPVDGERWMECDLQATAGGLAR
>NC_022657.1|WP_023357582.1|373112_374066_-|EamA-family-transporter-RarD
MGEERRGYLYGLTAYVLWGFFPIYFKLLAPSPPLEILAHRVIWSVVFISLLLLVLRNWRFLGQLARDRRLLGGITLAGLLIGVNWATYIYGVNSSRVVETALGYFITPLVVVLLGVTVQRERLRAWQWAAVGIGGLAVAVLTVDYGHLPYIALALAASFGSYSLVKKRLGLPPAEGLFVESAVLAVPALVYLGWLNATGGAEFGHVSATHTVLMLFSGIATAVPLLLFAGAANRVPLVGLGILQYVAPILQLAGGVLLFHEPMPAARLAGFGLVWIALIIFTVDGLRSARATKATKGRTAAASAAATAEPTAALPPR
>NC_022657.1|WP_023357581.1|372389_373100_+|zf-HC2-domain-containing-protein
MRCDHEHDDGAYVLGALSPAERAAYERHLATCSFCREAVADIAVLPGLLGRLDPADFEKLLAPDFPSPPPRNRRTSMPELVSAAQTTRRQERRKVRFRVLGSALAAACLALVVGVGAVFWMGRDATPPVVPGPTVAMTPANERVPVTAQINLTGAAGGTKINLVCFYNRGNSESEPYRIRLMAYGPDDESEQLGSWVASPGKEFSMSGVTHFTDGTLSRLALVRNDDKTLLSYDVP
>NC_022657.1|WP_023357580.1|371877_372393_+|sigma-70-family-RNA-polymerase-sigma-factor
MEDQDAELLRALQDEHGEALFAHAVRLSGGDRQRAEDLVQETLLRAWRYPEALDPERGAVRSWLFTTARNLAIDAWRRRSVRVGEVVTDMIPEPPPSADEADRAVEAWTVAEALGRLSTSHREVLVECFYQGRSVAEAAARLGVPPGTVKSRTHYALRSLRMVLDEMGVTG
>NC_022657.1|WP_023357579.1|371000_371795_+|helix-turn-helix-domain-containing-protein
MRDPLAEPSDLIRSVSRALRVLESVGRAPRGLTVKQIARRCELTVATTYHLVRTLAYEGYVIRREDGTYIVGLEIADRYRELVSAFRGPPSVGEALRRAAVETGYSHYLGRFVGGRIAVTASAEGARSPFMDDMAPGFDEGGHATALGKALLATLTADQRARYLRDWGMRAFTPATLTSPEALEADLAAGERRGMQLEMGQFRQGLACAAVNVVSDRDMERRLVLACALPAAEMLTSARVVRAKLTAAARNVAEALSTGDAATA
>NC_022657.1|WP_041840515.1|369641_370847_-|MFS-transporter
MAEPQISSAQTASTSTDAVQPRRAVTGALTTTIACSVPVFLVGGLAVQIGEELRFSPAGLGLAVSAYFGASALASVPAGALVERFGSTTIARAGIALASVSLLTIAVAARSLWTLIAILALGAAANALGQLASNTSLSRHVPVRRQGLSFGVKQAAIPVSTLLAGAAVPVVALTVGWRWAFVLAAVGAAGALWLVPSEKDETKRRQTGGGERATAALIVIGVGATLAAGSANALGTFLVDSAAARGMAPGTAGLALTLGGAVCVIARVFGGWQADRFPSRQIAVIAALLAVGAVGLALMAVAGTVTLVAGVVLGFGFGWAWPGLMNFAVVRLHPQAPAAATSITQTGVYAGGCLGPLGLGALAAAAGYPVMWTVAAIAMVWAAAAMVVGSRMLARHAAAMS
>NC_022657.1|WP_162181502.1|379830_381663_+|SseB-family-protein
MQPTAYAGESGGSSSRPASGLDGASGQPTSPRLGGGSEAGAAGPSSRPTGFAGPSGVSAASAATDDDSDTVTASRDEDQPTSGDAESSPSGVSAQGASSSEVPAAYRSPTIPAREASSGAARPNVPSALDALASRTGGSSALDALGSRGGRGATEMPPLQRPDAKLPTRTPMAQTPPLPAHIPPPVEVDEGPDENDSAPGGLPRRQVTPPSERPPSMAAAAQALAGRAPAAEPPAPAPQPGLAPPVIPGAGGAGRSSTPPVVPAAAARPSVPAPAPAQAPVSAPPVSREPADDDDDFVPANEVERDLYQAVGESSTDSFLSTLLLATVLVPVAHNSRPGSAPGESGFAFRTEEIDDERFLVVFTSRDRLGEHFAEPTRTVGVRFVDLIRNWPDPAWSFAVNPTSAIGAKYPGPQVIALASWAVEAGLGGDPADAPVETGAVTPLPTEQSAQLTTMQKAVPAEQIDYYLERGYDRVAGFVHRAGEVEHLRSPGELFAALGLLYDGSPYQPDAKEAFVLRWPAHRPSLYRIPYGGQSEQALRAMDGWVIERPPFRGNGFAPGEGKDVIAEFKVDSVRLPHGTQLWRMDENGDERMIAMFDCDAPVWRRVGEQ
>NC_022657.1|WP_041840517.1|381659_382025_+|hypothetical-protein
MMRDGYVVTWHGREYDAAPDGENVRIYAPEPGDGFEEARPGRYVRVLEPGEFGDLVYVRTTCSWRGEPFIVLAEADSWLRLEYTGGRAPVAHGLGLEEFDFGVYQGWAPAHEVTDLYEHRV
>NC_022657.1|WP_041840518.1|382028_382949_-|alpha/beta-hydrolase
MSAQVDETCVLTEGPWTHRFVGANGSRFHVVEAGTGPLVLLLHGFPEFWWTWHDMLTRIADAGFRAVAIDLRGYGASDKPPRGYDGYTMAADVTGLIRALGERSAMIVGAGAGGMIGWAAAAFHPKMVSRLVVLGAAHPLRLRAALFADPRGQFSASAGLLRFQVPRYEHVLTKDDAALVGELIERWSSPRWTETPEYAEYVARCREAIQIPQAAFCALEAYRWVFRSALRLQGYRFVKLMQQPLVTPTLQMHGALDTAVLPRTAQGSGRYVIAPYEWRLIEDAGHFIHQEAPDVVTGEVLRWLKA
>NC_022657.1|WP_023357591.1|382966_383428_-|hypothetical-protein
MIAFPRTAPATLLVLGFLTACSGPAVTPGTSVPVTPSGVTPSAAPSSTEPTPVPSGPYNSVPTGAPPSKPAGIPKTPTDNIPAGWTEGTVTRGGTGPCYGLVTFDGVPYAMYSDAGVTLTKGDHIKARLTPAKLRINCGEGTPVAMGAVQHFP
>NC_022657.1|WP_041840519.1|383543_385928_-|M6-family-metalloprotease-domain-containing-protein
MRKVVVGLLGAAMVSSVGIMLPAAAMAAPPVDPAPAQASKKAPVDDLPNPFEDKRRELRQEAVNGILKGTVKTQKRGGSTVAKVGKTRGGGETNRKVAKAGQDQYVEVGREQTDRIFVILAEFGNDRHPNYPDVDSDPATAGPTTFEGPLHNAIPSPDRTKDNSTVWQSDYNQAHYQDLYFGEGKNAESLKTYYETQSSGRYSVDGEVSDWVKVKYNEARYGRDCDITGLCTDTNMWALVTDAANQWVADQKASGRTDAQVKADMASFDQWDRYDFDGDGNFNEPDGYIDHFQIVHAGGDQSDGDPQQGEDAIWAHRWYAYNTSAGVTGPATNKAGGTQIGNTGIWIGDYTVQPENGGLSVFAHEYGHDLGLPDDYDTSGGSNNNSEFWTLMAQSRLSGAGEPLGTRPGDLGAWNKMQLGWLDYETVVAGQKKTLNLGPQEYNTKKAQAAVVVLPDKEVTTDLGAPFAGESQYFSGNDDNLNTTLTKSVDLTAATSASFDLKGRYNIEEGYDYLYFEGSTDGTTWTALNGTVDGAPLGVDGAVPPRPALGGDSGGAWKDISIPLTQYAGKKVQVRLHYITDGGLSAGGFFGDDLTITANGAVVSTDGAEGTPEWTAAGFSVEGSSITAEYDNFYIAGNRTYTSYDKYLKTGPYNFGWATTKPDWVEHFAYQQGLLISYNDTSFADNNVNVHPGGGRNLIIDSHPAPFYNLDGVPWRSRIQLYDAPFGTTKADSFTLHINGKPSYIRGQAAQPTFDDTKKYFYDEIPWAGVKLPAVGVKIKVVEQNGTSLKVKFS
>NC_022657.1|WP_023357593.1|386100_386439_-|hypothetical-protein
MAKILLALLAAILLAGCSEPVQKVQQPVSTPPSTPTDQFQYDDLIVGTVNRGGSGPCYGLVTDDGRQFALYENQGRELIKGVRVQVRAEPSTLRIDCGPGELLQVNALDEMR
>NC_022657.1|WP_023357594.1|386536_388921_-|M6-family-metalloprotease-domain-containing-protein
MRKVVVGLLGAAMVTSVGILVPAGATAAPPVDPAPVAKASGANSAPVDDLPNPLEDKRRALREAAVADVVSGKAKAVKKNGSTVVKVGRTQGSGVSNRAVAKAGEDQYVELGREQTDRIFVILAEFGNDRHPSYPDVDSNPAIPGPTTFEGPLHNKIPAPNRAVDNSTVWQADYAPSHYRDLYFGTGAGKESVKTYYETQSSGRYSVDGKVTDWVKVNYNEARYGRDLCGSNVCNNTWALVRDAANKWVADQQAQGRSDADIAADMKSFDQYDRYDFDGDGDFNEADGYIDHFQIVHAGGDAADGDPQQGEDAIWSHRWYAYGTDQGRTGPSGNLLGGTQIGNTGIWIGDYTIQPENGGLSVFVHEYGHDLGLPDDYDTSGGGDNNNEHWTLMAQSRLNAAGEPLGTRPGDLGAWNKLQLGWLDYETVVAGQSKTLNLGPQEYNTAKAQGVVVVLPDKEVTTELGAPFAGNGQFFSGNADDLNTSMTKDINLAGKTTAAVTLKGRYDIEADYDYLYFEASTDNGATWTRLDGTLNGAALPRDASNTPALTGSSAGAWSDIAIPLNAYAGKALKFRLHYLTDGGVSDGGFFGDDVTVTADGATVSADGAEGASTWALNGFSIVGATSTKEFDNFYIAGHRSYVSYDKYLKTGPYFFGYLPAKPDLVDHYAYQEGLLISYWDTSQVDNNTNVHPGMGRNLIIDSRPAPFYNLEGLPWRARIQVYDAPFSLKKADSFTLHINGKASYIRGQDAQPTFDDTKKYFYAELPNHGVKLPAVGVKMKVVSVDGTTLKVKIS
>NC_022657.1|WP_023357595.1|389179_391165_-|acetate--CoA-ligase
MSETLENLYSETRTFPPPAELAANANVKAEAYDEADENRQWFWEQQAKRLSWAKQWDQVLDWSNAPFAKWFVGGELNIAYNCVDRHVEAGHGDKVAIHWEGEPGDSRTVTYSDLLKSVSQAANTLTELGVTAGDRVAIYLPMIPEAAVAMLACARIGALHSVVFGGFSVDALATRIQDADCKVVITADGGYRRGKPSALKPTVDEAVAQCPSIEHVLVVRRTGEDVTWGDKDLWWHETVEQANDQHVPQAFDAEHPLFILYTSGTTGKPKGILHTTGGYLTQASYTFNAVFDIKPETDVYWCTADIGWVTGHSYIVYGPLSNGATQVMYEGTPDTPHKGRFWEIIDKYKVSLLYTAPTLIRTMMKWGDDIPAKYDLSSLRLLGSVGEPINPEAWMWYREHVGHDNAPIVDTWWQTETGAMMISPLPGVTASKPGSAMTPLPGISADVVNDEAESVPNGGGGFLVLREPWPSMLRGIWGDDQRFIDTYWSRFGKGAGVGDEWIYFAGDGAKKDDDGALWLLGRVDDVMLISGHNISTTEVESALVSHPSVAEAAVVGATDPTTGQAIVAFTIPRGNVDTSGDAGEKLIQELRNHVAKKLGPIAKPRQIMLVAELPKTRSGKIMRRLLKDVAENRSLGDVTTLQDSTVMDLISSGMQESKSED
>NC_022657.1|WP_023357596.1|391374_392118_+|hypothetical-protein
MTSDPLAPLLALADVEPAFTQAREHVDAAMRHRALRRNGGQVAAEVSLRAAVASAALEDHRYDLDEVRAGTVTDPVLQGALRVAEGVGGLVDLWPRAPRQVLARLHVLAARGVVPDDDLGRLTSAADRIDALAGLVAGNDRTPPLLLAAIVHAELITLKPFAGPAGLVARAAARLTLIGRGFDPRGIVGVEAGHLAREPEYTGSAGAYATGTPDGVRSWLRHYASAVSAGADEIAQIGDDVLTPSGT
>NC_022657.1|WP_023357597.1|392200_392680_+|PH-domain-containing-protein
MGDEWTRPYTPGTGRWLVIGWEAIALGLLGWSTVEQFGLAGPGIRVLATAIAALWVIGGWRIREMGVYVGPGGVRIRGLLRSRTMRWEDVAHVRLHRHTRKIGGFQLEGGMTVLIERRDGTMVNTELWAQGIDFHSRPHLFREVYHELRNRHLAAVAPA

Crispr_ID: NC_022657_5

• CRISPR_ID: NC_022657_5
• CRISPR_location: 1247817-1247901
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_022657_5

Consensus_repeat	Method
GGCCTAGCTTTGCGGCAGCGGCG	CRISPRCasFinder

spacers of NC_022657_5

>5.1|1247840|39|NC_022657|CRISPRCasFinder
TGCTGCAGGGCCCGACATCAAGGAAGTTGGGCTTGCGCT

CRISPR arrays and Neighbor proteins around NC_022657_5

CRISPR arrays

The CRISPR arrays of NC_022657_5

>merge|NC_022657|5|1247817-1247901|CRISPRCasFinder
GGCCTAGCTTTGCGGCAGCGGCGTGCTGCAGGGCCCGACATCAAGGAAGTTGGGCTTGCGCTGGCCTAGCTTTGCGGCAGCGGCG

>NC_022657|5|4|1247817-1247901|CRISPRCasFinder
GGCCTAGCTTTGCGGCAGCGGCG	TGCTGCAGGGCCCGACATCAAGGAAGTTGGGCTTGCGCT
GGCCTAGCTTTGCGGCAGCGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023358960.1|1252774_1254298_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143434
NC_022657.1|WP_023358953.1|1245865_1246123_+|WhiB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376791
NC_022657.1|WP_023358957.1|1249130_1249688_-|DUF3455-domain-containing-protein	unknown	unknown	gnl|CDD|314761
NC_022657.1|WP_041840637.1|1254737_1255421_+|endonuclease-V	unknown	unknown	gnl|CDD|377374
NC_022657.1|WP_041841826.1|1248109_1248700_-|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl|CDD|213022
NC_022657.1|WP_023358949.1|1239880_1240885_-|coenzyme-F420-0:L-glutamate-ligase	unknown	unknown	gnl|CDD|183957
NC_022657.1|WP_023358964.1|1256948_1257131_+|Trm112-family-protein	unknown	unknown	gnl|CDD|225391
NC_022657.1|WP_041840635.1|1243045_1245562_+|bifunctional-FO-biosynthesis-protein-CofGH	unknown	unknown	gnl|CDD|236422
NC_022657.1|WP_023358958.1|1249798_1251235_-|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143465
NC_022657.1|WP_023358947.1|1237434_1238550_+|mannose-1-phosphate-guanylyltransferase	unknown	unknown	gnl|CDD|223906
NC_022657.1|WP_041840633.1|1239316_1239877_-|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239646
NC_022657.1|WP_023358955.1|1246859_1247225_+|DUF3499-domain-containing-protein	unknown	unknown	gnl|CDD|378788
NC_022657.1|WP_063749524.1|1241957_1242920_+|hypothetical-protein	unknown	unknown	gnl|CDD|370676
NC_022657.1|WP_023358946.1|1236243_1237389_+|glycosyltransferase-family-4-protein	unknown	unknown	gnl|CDD|340838
NC_022657.1|WP_041840636.1|1254301_1254676_+|DUF779-domain-containing-protein	unknown	unknown	gnl|CDD|377532
NC_022657.1|WP_023358963.1|1255520_1256900_+|phosphomannomutase/phosphoglucomutase	unknown	unknown	gnl|CDD|236557
NC_022657.1|WP_052359331.1|1246155_1246620_-|metallopeptidase-family-protein	unknown	unknown	gnl|CDD|240574
NC_022657.1|WP_023358950.1|1240881_1241841_-|2-phospho-L-lactate-transferase	unknown	unknown	gnl|CDD|237443
NC_022657.1|WP_023358965.1|1257130_1258354_+|SIS-domain-containing-protein	unknown	unknown	gnl|CDD|181536
NC_022657.1|WP_023358959.1|1251327_1252632_+|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|225822

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023358960.1|1252774_1254298_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143434	cd07116, ALDH_ACDHII-AcoD, Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like. Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane. These proteins apparently require RpoN factors for expression.	0
NC_022657.1|WP_023358953.1|1245865_1246123_+|WhiB-family-transcriptional-regulator	gnl|CDD|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	3.95103e-27
NC_022657.1|WP_023358957.1|1249130_1249688_-|DUF3455-domain-containing-protein	gnl|CDD|314761	pfam11937, DUF3455, Protein of unknown function (DUF3455). This family of proteins are functionally uncharacterized. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 174 to 251 amino acids in length.	8.18433e-15
NC_022657.1|WP_041840637.1|1254737_1255421_+|endonuclease-V	gnl|CDD|377374	pfam04493, Endonuclease_5, Endonuclease V. Endonuclease V is specific for single-stranded DNA or for duplex DNA that contains uracil or that is damaged by a variety of agents.	3.81622e-101
NC_022657.1|WP_041841826.1|1248109_1248700_-|polysaccharide-deacetylase-family-protein	gnl|CDD|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	3.22841e-66
NC_022657.1|WP_023358949.1|1239880_1240885_-|coenzyme-F420-0:L-glutamate-ligase	gnl|CDD|183957	PRK13294, PRK13294, F420-0--gamma-glutamyl ligase; Provisional.	2.27793e-110
NC_022657.1|WP_023358964.1|1256948_1257131_+|Trm112-family-protein	gnl|CDD|225391	COG2835, COG2835, Uncharacterized conserved protein [Function unknown].	6.06499e-15
NC_022657.1|WP_041840635.1|1243045_1245562_+|bifunctional-FO-biosynthesis-protein-CofGH	gnl|CDD|236422	PRK09234, fbiC, FO synthase; Reviewed.	0
NC_022657.1|WP_023358958.1|1249798_1251235_-|aldehyde-dehydrogenase-family-protein	gnl|CDD|143465	cd07147, ALDH_F21_RNP123, Aldehyde dehydrogenase family 21A1-like. Aldehyde dehydrogenase ALDH21A1 (gene name RNP123) was first described in the moss Tortula ruralis and is believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and ALDH21A1 expression represents a unique stress tolerance mechanism. So far, of plants, only the bryophyte sequence has been observed, but similar protein sequences from bacteria and archaea are also present in this CD.	0
NC_022657.1|WP_023358947.1|1237434_1238550_+|mannose-1-phosphate-guanylyltransferase	gnl|CDD|223906	COG0836, {ManC}, Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane].	1.07534e-129
NC_022657.1|WP_041840633.1|1239316_1239877_-|NUDIX-hydrolase	gnl|CDD|239646	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	2.75596e-38
NC_022657.1|WP_023358955.1|1246859_1247225_+|DUF3499-domain-containing-protein	gnl|CDD|378788	pfam12005, DUF3499, Protein of unknown function (DUF3499). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.	6.07108e-58
NC_022657.1|WP_063749524.1|1241957_1242920_+|hypothetical-protein	gnl|CDD|370676	pfam09770, PAT1, Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.	8.86005e-12
NC_022657.1|WP_023358946.1|1236243_1237389_+|glycosyltransferase-family-4-protein	gnl|CDD|340838	cd03809, GT4_MtfB-like, glycosyltransferases MtfB, WbpX, and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.	8.81921e-96
NC_022657.1|WP_041840636.1|1254301_1254676_+|DUF779-domain-containing-protein	gnl|CDD|377532	pfam05610, DUF779, Protein of unknown function (DUF779). This family consists of several bacterial proteins of unknown function.	2.79321e-61
NC_022657.1|WP_023358963.1|1255520_1256900_+|phosphomannomutase/phosphoglucomutase	gnl|CDD|236557	PRK09542, manB, phosphomannomutase/phosphoglucomutase; Reviewed.	0
NC_022657.1|WP_052359331.1|1246155_1246620_-|metallopeptidase-family-protein	gnl|CDD|240574	cd12954, MMP_TTHA0227_like_1, Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria. The subfamily includes some uncharacterized bacterial proteins which show high sequence similarity with Thermus thermophilus hypothetical protein TTHA0227. However, they do not contain the conserved HExxH (x could be any amino acid) motif. They may not have any zinc metallo-peptidase activity.	4.12063e-27
NC_022657.1|WP_023358950.1|1240881_1241841_-|2-phospho-L-lactate-transferase	gnl|CDD|237443	PRK13606, PRK13606, LPPG:FO 2-phospho-L-lactate transferase; Provisional.	6.59992e-156
NC_022657.1|WP_023358965.1|1257130_1258354_+|SIS-domain-containing-protein	gnl|CDD|181536	PRK08674, PRK08674, bifunctional phosphoglucose/phosphomannose isomerase; Validated.	8.4428e-46
NC_022657.1|WP_023358959.1|1251327_1252632_+|GAF-domain-containing-protein	gnl|CDD|225822	COG3284, AcoR, Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription].	1.20252e-23

Protein sequences

>NC_022657.1|WP_023358955.1|1246859_1247225_+|DUF3499-domain-containing-protein
MRSPRRCSRNGCPRQAVATLTYVYSDSTAVVGPLAAFAEPHTYDLCEPHARSLTAPRGWELVRHDGDFAPPPPTTDDLVALADAVREAARPAPPPRPEEHDNLPGHQTGRRGHLRVIPPSH
>NC_022657.1|WP_052359331.1|1246155_1246620_-|metallopeptidase-family-protein
MRPGADPGRSARAGGPGRPARRDRHGRGLRGRLVPATVPLARTKAEIFDDLVLDTVESLERRYAKELAGVEFAVEDVPPELNVYDSDVLEDGEVPLARLLPGRPGRQELPPRIVLYRRPLEFRAMDREDLADLVHDVIIEQVANLLGVDPDELS
>NC_022657.1|WP_023358953.1|1245865_1246123_+|WhiB-family-transcriptional-regulator
MEAQVEGVDLLGDAPEWQERALCSQTDPEAFFPEKGGSTREAKRICGRCDVKSECLEYALGHDERFGIWGGLSERERRKLKRRVA
>NC_022657.1|WP_041840635.1|1243045_1245562_+|bifunctional-FO-biosynthesis-protein-CofGH
MADVTEASIRRALKRASDGKAVDADEATALLAAEGPLFDELLAIAGGVRDAGLREAGRPGVVTYSKKVFIPLTRLCRDRCHYCTFATVPHRLPAAFLERDEVLAIAREGAAQGCKEALFTLGDRPEERWPAARQWLDERGYDSTLDYVRACAIAVLEETGLLPHLNPGIMSWAELQRLKPVAPSMGMMLETTATRLWSEPGGPHYGSPDKEPAVRLRVLDDAGRVGVPFTTGILIGIGETPAERVDALFAMRRTAREFGHIQELIIQNFRAKPDTAMRGMPDAELRELAATVAVARVINGPRARIQAPPNLIAGEFALLLRAGIDDWGGVSPVTPDHVNPERPWPQIESLRQHSREAGFELRERLTIYPEYVRRGENWLDPRLAAHVAALSDPETGLAREDAMPVGLPWQEPDDAYAAGGRTDLFASIDTDGRTSDRRGDFDSVYGDWDEVAAHISAEAVAAGAGKVVPRVESDVLAGLKLAAEDPGALLDPANEVKAMALFNADGSALDELARIADDLRREVNGDDVTYVVNRNINFSNVCYVGCRFCAFAQREKDADAYRLSVEQVADRAEEAWKDGATEVCMQGGIDPKMPITAYADLVRAVKSRVPGMHVHAFSPMEIVTGAAKAGVSVRDWLTELHEAGLDTIPGTAAEILDDDVRWVLTKGKLPASAWIDVVTTAHQVGIRSSSTMMYGHVDHPRQWLGHFRVLAGIQDTTGGFTEFVGLPFIHTNAPIYLAGIARPGPTWRENRVVHAMARILLHGRIGNIQCSWVKLGDEGTVAMLNGGCNDLGGTLMEETISRMAGSEHGSARTVAQLKELAASAGRPAAERTTVYGRR
>NC_022657.1|WP_063749524.1|1241957_1242920_+|hypothetical-protein
MTSTPPPQPAGRPVLPVIRPLRDLAAYALVAAPAVWLFVAVIRLIPSGVGQDFLTRVQNSFYSFVNVELVALPIAAVLLATLVQPVHKHAKLITVAALIEYAVAGFFAIVFGFLIGLINIARWSVRVAFEEFLVRTAWLAVFAAAAYAVFLIWRNLYYTPKPKAPQGMYGQPQQQWQQQPPPQYGGQPGYLQPGQPGQPGQPGFGQQPPPGQWGQPQQPYAQPAWGEPTTVQPPVAPPSSAPPAQPVSAQPASGGAPGTPPGPFAPQPGHPQGYGAPSYPPQPPYGQPQPGPADATQAMPPRPADEDRTQIVGEEHPPRQ
>NC_022657.1|WP_023358950.1|1240881_1241841_-|2-phospho-L-lactate-transferase
MRIVVLTGGIGGARFLVGVRAHARRIGAEVTAVVNVGDDVRMHGLQICPDLDSVMYTLGGAADPDRGWGRVGETWVVKEELAKYGAEPSWFGLGDKDTATHLVRTTMLNAGYPLSAVTTALCDRWQPGIKMLPASDDRLETHVVVDVEGERKAIHFQEWWVRYRGDVPTHRFVFVGAETAKPAAGVLEAIGNADVVLVAPSNPVVSIAPILAVQQLKEAVLDGPAPVVGVSPIIGGSPVRGMADRCLATLGVEVSANGVAGLYGARRDNGLLDGWLVDTTDESANIPGVTTRAVPLWMTDEDKTATMVAEALRLAEELR
>NC_022657.1|WP_023358949.1|1239880_1240885_-|coenzyme-F420-0:L-glutamate-ligase
MIDGLEVLPVRGIGDVTAGDDLAALITANAPWLRDGDVLVVTSKIVSKAEGRLVEVPADGPERELARERALASETRRVVARRGPTAIVQTHHGFVMAAAGIDASNVDKTHLVLLPADPDASARALRTALAARGLHVGVVISDTMGRAWRNGLTDVALGAAGIEPFRDHRGEIDPYGNELQLTQMAVIDELAAAGELVKGKCDQVPVAVVRGYPGAGTTETSGAVVLLRDAASDMFSLGTAEAHTAGLVSAATLPDTQPAAPGASTAAIARALATVADVITCAVSSSLTCTPVDLTPSGLMRLGADVHRLRSALAAEGLTSTVTWSDTSAQITVS
>NC_022657.1|WP_041840633.1|1239316_1239877_-|NUDIX-hydrolase
MRATVLYDNAVATLTAWQATSDEADLARKRTLELLTAGPAAMTRAHRPGHVTASTLIVDDQRRVLLCLHGRLGMWMQLGGHCEPTDETLTSAALREATEESGIPGLRLDPDPIDVDIHAVRCGAAPGEPATESLHYDVRFLAVCPPGAIESISEESTALAWFTPDALPSPLAAGVTQQLAPAFARL
>NC_022657.1|WP_023358947.1|1237434_1238550_+|mannose-1-phosphate-guanylyltransferase
MSENPGELYAVVPAGGSGTRLWPLSRAGHPKFLHPLTGTDASLLQATVERLAPLADPSRVLIVTGVAHAAAVARQLTELPAENILVEPSPRDSCAAIALAAAVIARRDPEAIMGSFAADHLIAENDRFINVIRQAMTGARQGLLMTLGITPTRPETGYGYVQCGGPVGDGPVLSVEEFKEKPLYDVAESYVKSGNYLWNAGMFVWRVDVFLSELARQQPQLHAGIARIAQAWDSPSREEVLGEVWQTLPRISVDYAVMEGAATVGRVGTVPGDFGWNDVGDFHTLGEVLTADSGGNVVVGSDVLNTPSVLLRETENLVVVPNSGRLVAALGVRDLIIVDTPDAVLVCPRNRAQEVKSLVDELKSKGDLHYI
>NC_022657.1|WP_023358946.1|1236243_1237389_+|glycosyltransferase-family-4-protein
MTAGSPPRVLVDATSVPADRGGVGRYVDGLLGALGAIGPDRLDLAVVAQRSDAERYSRMLVNAEVIAGPSAVAHRPARLAWEQTGLPLLAQQVGAKVLHSPFYTCPLRAGCPVTVTVHDATFFTEPEHYDNTKRTFFRSAIKTSLRRAARVIVPSKATRDELIRLLDADPTHIDVAYHGVDQTAFHAPTEEEKARVRARLGLTDAGYVAFLGAKEPRKNVPNLIRGWARAVADWPRPPALVIAGGQGHDDDIDRAVAEVPSHLRLLRPGYLRYADLPGFLGGALVACYPSFGEGFGLPILEAMACATPVLTTPRLSLPEVGGDAVAYTTEDPDRIAEDLADLLHDEPRRLTLAKAGFDRAKEFTWAGSAEVHVATWNRVAV
>NC_022657.1|WP_041841826.1|1248109_1248700_-|polysaccharide-deacetylase-family-protein
MKTGDTGVALTFDDGPDPAQTPRMLDLLKKNHVKATFCVVGENAQAFPDLIKRIVDEGHTLCNHTWRHSLTLGKKKPATIKADLQRTNDAIHAAVPDAPIKYMRAPGGNFTDRFVTVASELGMKSIYWQVDPRDWEHPATETDGAHKAKIIHSVKKHVGKGAIVLSHDYAQPDTIEAYEELLPWLKGRYKLVALPR
>NC_022657.1|WP_023358957.1|1249130_1249688_-|DUF3455-domain-containing-protein
MPRTRTRLRALTLAAAATVVAGVGAVTYQASAAELAGGPGPRPHPSASPSPIDPPAGAKRIGSFRVTTGTQTYTCTGGVFTGSSVPEAQLAGPGGRIHHFKGPSWQSTRDGSLVTAKKKDELPRTGAIPELLLEVTSHSGPADGLLAKATYIQRLSTTGGLAPAGACTDGATKAVRYGAVYVFWA
>NC_022657.1|WP_023358958.1|1249798_1251235_-|aldehyde-dehydrogenase-family-protein
MDTTAFYVAGEAVHGDEEVAVTHPYDGRVVGRTTWARDEQVEAAVAAAAAVADRAAALPAHVRAAALDHVSRRIGERREEIAALITAENGKPLKWARIEADRAVSVFRWAAEEARRFAGDLQRLDTDPGGTGRIAVVRRVPRGPVLGISPFNFPLNLVAHKVAPAIAVGAPIVLKPAPATPLTALLLGEILAETDLPAGMFSVLPVPNDRAPALVADPRLPIVSFTGSGPVGAQIRRAAPEKHVTLELGGNAAVLLCADYGSDADLDWAAQRVATFGTYQAGQSCIAVQRVYVHAAHTGFLPRLTEAVAALRTGDPNDPEVEVGPMISEDAAKRVEQWVDEAVAAGATVVAGGKRDGATYPPTVLTGVPAGAKVVAEEVFGPVLVVSEVTDDTAGFAAINNSAYGLQAGVFTHSIQTAFTAHRELKVGGVIVGDVPSYRADQMPYGGVKGSGVGREGVASAMDDYTEPRVMVLTGVDL
>NC_022657.1|WP_023358959.1|1251327_1252632_+|GAF-domain-containing-protein
MSNPWLALTLGADPTERISQVGRAHERFVTGEQAVTQVRSVVADSWRRSAGALVNPDSTAPIELSDGDLEAYRAAHPLARVLPIFRDLLGGLADDGDHMMAVCDAHGRLLWVEGTASVLRGAESMNFVPGARWDEAHAGTNAPGTALAVDHPLQIFATEHFSRGVQRWTCAAAPIHDPATGRLLGAIDVTGGDHLANPHSLALVRATALAAEAYLSAHQPAPEKHAATVSVSGREDAVLSVGGRRLRLGRRHSELLVLLLVHPEGRTGDQLAFDLYADDLNPVTVRAELSRLRRILGPELLDSRPYRLRAELGADFLTVTRLLECGLVAEALAAYDGPLLPSSDAPGIVRLRRLIDSRLRAAVLTGGDPRLIQTWVGAPWGADDLEMWEAYATALPPGSPARPHALNRVVELAGEYGLRPSVSGTPKMTRRLLP
>NC_022657.1|WP_023358960.1|1252774_1254298_+|aldehyde-dehydrogenase-family-protein
MAIYSPPGTDGAVVNYESRYDHWIGGEYVPPAKGQYFENPSPVNGQNFCEIARGTADDVERALDAAHGAADAWGRTSVAERANILNRIADRMEQNLEKLAVAETWENGKPVRETMAADIPLAIDHFRYFAGALRAQEGTLGEIDDDTVAYHFHEPLGVVAQIIPWNFPILMAVWKLAPALAAGNAVVLKPAEQTPASIHYWMSLIADLLPPGVVNIVNGFGVEAGKPLASSNRVAKVAFTGETTTGRLIMQYASENIIPVTLELGGKSPNIFFDDVSAADDDFLDKALEGFSMFALNQGEVCTCPSRALIQQGHYSDFLAAGVKRVENMKQGNPLDTDTQVGAQASNDQLEKILSYFDIGRQEGAKVLIGGARADLGGDLAGGYYVQPTVFEGSNSMRIFQEEIFGPVVSVTSFSDYADAIKTANDTLYGLGAGLWTRDSNTAYRAGRAIKAGRVWTNCYHLYPAHAAFGGYKQSGIGRENHKMMLDHYQQTKNLLVSYSPKAMGFF
>NC_022657.1|WP_041840636.1|1254301_1254676_+|DUF779-domain-containing-protein
MGARVDVTPAAADLMRSLRGQHGPLMFHQSGGCCDGSAPMCYLEGEFRTGASDVLLEELHIDGVDEPISFWMSTSQYQAWKHTHITVDVVPGRGSGFSLEAPEGVRFLIRSRVLTPEEVAALPS
>NC_022657.1|WP_041840637.1|1254737_1255421_+|endonuclease-V
MTGLPLTGFPRTEEEALAVQDALRPRVIGGPGPADPTTVAGLDVAYHEDGDRLAAAIVVLDTRTHEVRDTAVVQGKPSFPYIPGLFAFREIPALLEALEKLTVRPDVLICDGHGLAHPRRFGLACHLGVLTGLPSFGVGKTPLIGTWTPPADRRGARSDLVDAGEVVGAVLRTRQAVKPVFVSVGHRMDLDTACALTLTLTPRFRLPETTRAADRACRDALISTPRT
>NC_022657.1|WP_023358963.1|1255520_1256900_+|phosphomannomutase/phosphoglucomutase
MTDLSQLVKAYDVRGVVPDQLNETVARALGTAFVEMLRESGDAAERIVIAHDMRETGPGLAAAFAAGANSAGATVVHTGLGSTDQLYYASGVLGLPGAMFTASHNPAQYNGIKLCRAGARPVGQDSGLVVMRRYAEGLLDDLAAVGEVPPAIEHVNLLADYARHLRSLVDLSGIRPLKIVVDAGNGMGGYTVPAVLGDQELEALPLEIVPLYFELDGSFPNHEANPLDPANLVDLQAAVREHGADLGLAFDGDADRCFVVDENGDPVSPSAITALVAKRELAKFPGSTVIYNLITSHAVPEIIEENGGLPVRSRVGHSFIKAEMARTNAVFGGEHSAHYYFRDFWFADTGMLAALHVLAALGGQDQPLSLFAAEFERYSASGEINSTVADAAAKVAEVRAAYSGATFDELDGMTVQLADGAWFNLRASNTEPLLRLNVEAAKPDRMAALRDEVLAIVRG
>NC_022657.1|WP_023358964.1|1256948_1257131_+|Trm112-family-protein
MALDPQLLEILACPDTHHAPLDYDAGAQTLTCTECGRVFEVRDDIPVLLLDEATTPGKAS
>NC_022657.1|WP_023358965.1|1257130_1258354_+|SIS-domain-containing-protein
MAGPIEGAAGLTGRRVADESLLEDEKTMLENDPGGMLRATASAGAQVRESAALAAEANLTVLADEGRPRAVVVAGIGTAGLTGSILATVAGPRCPVPVIGHRSAGVPGWVGAADVVIAVSASGRSPEALAAADAAARRGARLVAIGNPDSELQAMAERARAPFIPVPRRAPARASLWGLAVPVLLAARSLGLVKVNEADLAETAARLDADAERCRANAESFTNPAKSLALGLAGSIPIVWGSSPLATVAARRFADTLAANARYPVMAGALGEAGRGRVGLLDGPFGGLAESSRDIFADPDEEEEANTRLRLVVFRDGGLNPEDEADEPVAVEERRADAVQTLAERRGVRCDVVTAEGGSALERLASLVAVPDFASIYLALAHGLDPMAVPAINEMKELSNPMPEGLQ

Crispr_ID: NC_022657_6

• CRISPR_ID: NC_022657_6
• CRISPR_location: 1291739-1291832
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_022657_6

Consensus_repeat	Method
CCCCACGGTGCGGCACGTTGCGC	CRISPRCasFinder

spacers of NC_022657_6

>6.1|1291762|48|NC_022657|CRISPRCasFinder
GTGATGGGTGGTAGCTCATGTTCGCTCCGAGGCCTAGCCTCCGGAAGC

CRISPR arrays and Neighbor proteins around NC_022657_6

CRISPR arrays

The CRISPR arrays of NC_022657_6

>merge|NC_022657|6|1291739-1291832|CRISPRCasFinder
CCCCACGGTGCGGCACGTTGCGCGTGATGGGTGGTAGCTCATGTTCGCTCCGAGGCCTAGCCTCCGGAAGCCCCCACGGTGCGGCGCGTTGCGC

>NC_022657|6|5|1291739-1291832|CRISPRCasFinder
CCCCACGGTGCGGCACGTTGCGC	GTGATGGGTGGTAGCTCATGTTCGCTCCGAGGCCTAGCCTCCGGAAGC
CCCCACGGTGCGGCGCGTTGCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023358988.1|1285687_1286803_+|peptide-chain-release-factor-2	unknown	unknown	gnl|CDD|234799
NC_022657.1|WP_023358989.1|1286964_1287645_+|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl|CDD|225438
NC_022657.1|WP_023358993.1|1290552_1291224_+|cellulose-binding-domain-containing-protein	unknown	unknown	gnl|CDD|366161
NC_022657.1|WP_023359000.1|1296991_1297567_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023359003.1|1300812_1301772_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379258
NC_022657.1|WP_023358986.1|1283200_1284829_+|L-glutamate-gamma-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|143441
NC_022657.1|WP_148308254.1|1288774_1289953_+|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl|CDD|366703
NC_022657.1|WP_023358997.1|1294543_1295233_-|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl|CDD|274303
NC_022657.1|WP_041840642.1|1285105_1285621_+|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NC_022657.1|WP_041841831.1|1282043_1282961_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023358990.1|1287708_1288584_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|225088
NC_022657.1|WP_023358995.1|1292960_1293632_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023358998.1|1295263_1296070_-|S-methyl-5'-thioadenosine-phosphorylase	unknown	unknown	gnl|CDD|236107
NC_022657.1|WP_084298336.1|1293968_1294547_+|LuxR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197715
NC_022657.1|WP_023358999.1|1296195_1296753_+|YqgE/AlgH-family-protein	unknown	unknown	gnl|CDD|234694
NC_022657.1|WP_023358994.1|1292214_1292934_+|hypothetical-protein	unknown	unknown	gnl|CDD|319937
NC_022657.1|WP_023359001.1|1297581_1297875_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023358992.1|1290029_1290506_+|SsrA-binding-protein-SmpB	unknown	unknown	gnl|CDD|235455
NC_022657.1|WP_023359002.1|1297871_1300664_-|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|226418
NC_022657.1|WP_041841830.1|1281565_1282069_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023358988.1|1285687_1286803_+|peptide-chain-release-factor-2	gnl|CDD|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NC_022657.1|WP_023358989.1|1286964_1287645_+|cell-division-ATP-binding-protein-FtsE	gnl|CDD|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	1.36283e-123
NC_022657.1|WP_023358993.1|1290552_1291224_+|cellulose-binding-domain-containing-protein	gnl|CDD|366161	pfam00553, CBM_2, Cellulose binding domain. Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.	2.96796e-11
NC_022657.1|WP_023359003.1|1300812_1301772_-|helix-turn-helix-domain-containing-protein	gnl|CDD|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	1.7627e-06
NC_022657.1|WP_023358986.1|1283200_1284829_+|L-glutamate-gamma-semialdehyde-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
NC_022657.1|WP_148308254.1|1288774_1289953_+|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	2.31304e-38
NC_022657.1|WP_041840642.1|1285105_1285621_+|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	6.32551e-06
NC_022657.1|WP_084298336.1|1293968_1294547_+|LuxR-family-transcriptional-regulator	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	3.75576e-18
NC_022657.1|WP_023358990.1|1287708_1288584_+|ABC-transporter-permease	gnl|CDD|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	1.77569e-61
NC_022657.1|WP_023358997.1|1294543_1295233_-|lytic-transglycosylase-domain-containing-protein	gnl|CDD|274303	TIGR02794, Protein_TolA, TolA protein. TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	0.00776095
NC_022657.1|WP_023358998.1|1295263_1296070_-|S-methyl-5'-thioadenosine-phosphorylase	gnl|CDD|236107	PRK07823, PRK07823, S-methyl-5'-thioadenosine phosphorylase.	6.69503e-167
NC_022657.1|WP_023358999.1|1296195_1296753_+|YqgE/AlgH-family-protein	gnl|CDD|234694	PRK00228, PRK00228, YqgE/AlgH family protein.	4.84304e-58
NC_022657.1|WP_023358994.1|1292214_1292934_+|hypothetical-protein	gnl|CDD|319937	cd08349, BLMA_like, Bleomycin binding protein (BLMA) and similar proteins. BLMA also called Bleomycin resistance protein, confers Bm resistance by directly binding to Bm. Bm is a glycopeptide antibiotic produced naturally by actinomycetes. It is a potent anti-cancer drug, which acts as a strong DNA-cutting agent, thereby causing cell death. BLMA is produced by actinomycetes to protect themselves against their own lethal compound. BLMA has two identically-folded subdomains, with the same alpha/beta fold; these two halves have no sequence similarity. BLMAs are dimers and each dimer binds to two Bm molecules at the Bm-binding pockets formed at the dimer interface; two Bm molecules are bound per dimer. BLMA belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. As for the larger superfamily, this family contains members with or without domain swapping.	3.37804e-19
NC_022657.1|WP_023358992.1|1290029_1290506_+|SsrA-binding-protein-SmpB	gnl|CDD|235455	PRK05422, smpB, SsrA-binding protein SmpB.	2.05942e-89
NC_022657.1|WP_023359002.1|1297871_1300664_-|winged-helix-turn-helix-domain-containing-protein	gnl|CDD|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	2.9449e-41

Protein sequences

>NC_022657.1|WP_023358993.1|1290552_1291224_+|cellulose-binding-domain-containing-protein
MSAKHSTAFPLRRYGFIAGAATLLVVLVAWVAVRAVGPVSQDNRTPLMMQPTIPVGDTSFAPSPSASPSPSLSPSRSPSPRSSPSPSRSRSASASASASVSVSASDSASPKPTPARTTSTPVPASLSARYQVGAGWDRGFVGWVQITNTGQTAATWTVKISYPSRAGVRITNVWNAQRDGSSFTGGPLAPGASASFGFEATKQVRDKISPTACTINGAPCRMS
>NC_022657.1|WP_023358992.1|1290029_1290506_+|SsrA-binding-protein-SmpB
MPREQGRKVVASNRKARHDYAILDTYEAGMVLTGTEVKSLRLGRSSLVDAFGHENNGEIFLHGMHIPEYTQGTWTNHEPRRVRKLLLKRDEIAKLMGKLRDDGVTLVPLSVYFNNGYAKVELGLAKGKKAYDKRQDLASRDAQREINKAMGRRSKGMD
>NC_022657.1|WP_148308254.1|1288774_1289953_+|peptidoglycan-DD-metalloendopeptidase-family-protein
MAAPGAAVAGPDNDAKRAGRAVERAEAILEHATATARNAARRLETATAALPTAQKKVATTRGIVAAASVEAATARRKADAARASYGKVADRFEQAQEQVVEARDRVDEIAAASYMGGNFATLNVLVGARGPQDAMDRLGLVDQVMQKQQEGVDQLLGARRSARTEQDRAGLAKRVAEEAEKEAADKLEAAKDAQVAARRARAAVIELAQSRRQALSVARSQRSAVLAKYEAAKAEEARIQDALRNWDQKTGGSTYLGGKLLMPVHGWKSSDYGTRYDPYYRVWQLHAGTDFAAGGGTPIHAAASGRIIQAGWAGGYGNYTCISHGKKQGRGFSTCYGHQSKILVHVGEYVRRGEVIGRVGTTGASTGFHLHFETRFGGVPKNPLNYLPGCLC
>NC_022657.1|WP_023358990.1|1287708_1288584_+|ABC-transporter-permease
MRFKYVLNEVLVGLWRNVTMTIAMIITMSVSLTMLGASVLMYMQVDQMKSYYYGEIEVSIFLREDVTEAQRAAITQAIDTNGLVQSKTYETRAQAFEKFKVLWRDSPDFVKSVGPDSLPESFRVKLKDPEQYQAFAEQIQGLPGIQDIVDQRELLDKVFKIFNAIQVGALVVAGFMALAALLLVGNTIQVAAYSKRREVAVMKLVGASNWFIQAPFVLEAVVAGLIGAILGFVFIFIGKVVLLDGRLQALTNVLTPIPDGNVWLMLPLLAGVGAGVSAITAWITLRFYLKV
>NC_022657.1|WP_023358989.1|1286964_1287645_+|cell-division-ATP-binding-protein-FtsE
MIQLENVTKTYPKASRPSLDDVSVGIEKGEFVFFIGPSGSGKSTIIKLLLHEVAPSRGKVVVNAKDVTTMRSWKIPHFRRSIGCVFQDFRLLPNRTAYENVAFALEVIGKTKAVARRVVPEVLELVGLGGKEHRYPHELSGGEQQRVAVARAFVNRPLILLADEPTGNLDPDTSIEIMRLLDRINRTGTTVVMVTHDSNIVNQMRRRVIEIESGRIVRDQARGVYG
>NC_022657.1|WP_023358988.1|1285687_1286803_+|peptide-chain-release-factor-2
MSAADFPEQLKALDATLRNIENVLDVDKLRRDRAVLEEQASAPDLWDDQARAQEVNSRLSYLTGEIHRMEKLRQRIDDAELLLEMAQDADDEGSIAEVGDELVSLTKAVEEMEVRTLLSGEYDSREAVVAIRAGAGGVDAADFAEMLMRMYLRWAERHGYPTEVYETSYAEEAGLKSATFAVKVPYAYGTLSVESGTHRLVRISPFDNQGRRQTSFAGVEVMPVVEQTDHIDIPDNELRVDVYRSSGPGGQSVNTTDSAVRLTHIPTGIVVTCQNEKSQLQNKASAMRVLQARLLERKRQEEEAKMAGLKQDTTGSWGDQMRSYVLHPYQMVKDLRTEQETGNPSSVFDGELDEFIEAGIRWRKQTQIAAG
>NC_022657.1|WP_041840642.1|1285105_1285621_+|PadR-family-transcriptional-regulator
MPDSQINPTAAALLGLLHEGPMTGGQLMAAAERRLGPYWSMTRSQVYRELPVLAEMGFVRLGKPGPRSSQPYAITASGKRAFSRWLAESPGRDAIRNPVALRVAFGSQHSGNQLKTLYTGANEYHSEALAMAREQAKEAKKAGDAYGAAALEFAVAYHKAALSWLKVAPAE
>NC_022657.1|WP_023358986.1|1283200_1284829_+|L-glutamate-gamma-semialdehyde-dehydrogenase
MDALLAVPEPRNEPVRSYAPGSPERASLQARLDAMAGERLDLTMTIDGTRTMGGGNTIDVVQPHKHSHVLGVTGNATHADATAAVAAAKRAAPGWRALPFSERAAVFLRAAELLAGGWRDTLNAATILGQSKSVYQAEIDAACELIDFLRFNAAFGEKILGEQPQSSPGVWNRFDHRPLEGFVYAITPFNFTAIAGNLPSAPALMGNTVVWKPSPTQQLSAHFTMRLFEAAGLPPGVINMVTGDGLAVSDVVLADPDLAGIHFTGSTATFRHLWREVGSNIDRYKAYPRLVGETGGKDFVFAHASADVDMLHTALIRGAYEYQGQKCSAASRAYVPRSIWEGGLRDRLAASVSSIRYGDVTDLSTFGGAVIDGRAFAKHASALDRIKNSASCTVLAGGTADDSEGFFVAPTLVESTDPAHEIFTTEYFGPILGVHVYEDGAFETAVAQAEAVSPYALTGSIFATDRTVVDWAAGALRNAAGNFYINDKPTGAVVGQQPFGGARGSGTNDKAGSVLNLHRWVSPRTIKETFEAPTDWRYPHMG
>NC_022657.1|WP_041841831.1|1282043_1282961_-|hypothetical-protein
MLWSARATITGRADVEMEVTSTAYALPGAISASLVAGAAVALAVLAFLTRGGRTPGVTVRFIIATGAGLGLGALGALSIITINTEGWLYAVVGGTVAAAATIGGALAGLRYPRVIAAVCWGAVAVFVVGFVLNYLQDPLLSALGSGDTAASQTGAASWFALLQSVLSGVAGAVVAYRVLRRARRRSGSDVRWPFYALAGAGPGLLLIVGEALTRTAGSRVLELAGKVSELELTVQQMLSGSRLNNGLIVLFVGAFTGMIAVGRTMGSPAAAPAPAPAPASPPVDPDAIEQEARADEPSTATRPAP
>NC_022657.1|WP_041841830.1|1281565_1282069_+|hypothetical-protein
MTDLVRVYVPATVPMLAEMRTTGQLGAGPVVAHAVTPALREWYAEGDEEELEYVAFTRAAQAALQLLRHDPKAPRRRVVVSADVASTALVREDVELGSSTVRLPQPISLKEVASIHLDGLSAAAEIGAAADVVEEALAGDPDAQFTVDGAEDHELEWYAVTELDELL
>NC_022657.1|WP_023358994.1|1292214_1292934_+|hypothetical-protein
MSNEVTVPLLPCGSIDDIENFYGVLGFSTTYKQRKPNAAVGLRREDLHLQFFEIAGFEPEQSYGSCLVLTEDIAGLHRAFAAGMRAAYGKVLVAGVPRMTRPRARKNADGVGGFSVVDPGGNWIRVFQKPDTMSATAPAAAGRLAKALANAVVLADSKGDVGQAARILDSALARPQDDDDPVTHVEVVVYRAELAIALDDRETAVEMLARVERIALNADETGRAAPTFEIAADLAAALR
>NC_022657.1|WP_023358995.1|1292960_1293632_-|hypothetical-protein
MTVSKPVSAAAVVVAIVLGACAAGGGDEPPPPPAPRPKKQTVSKPAQRSAALVLTQNGLPGLELNRQVLDVSTSDMEAAFDNHDFLNAGQTNTCGLAANEDLGVAAITNTDLAVVAFVVERPDTATTEGIRLGSTTDDIIKAYGKNAVYARDVPSRAGGQLIWVTDLDSPDSEPSASSLHYAFETDTTGTVTRLRAGFWPHVAHIDFCSDKATRTKETGWPLT
>NC_022657.1|WP_084298336.1|1293968_1294547_+|LuxR-family-transcriptional-regulator
MHESPLIRHFVRHPGPGVIGVSELVSRREWRENAVYRESLRHLGFGDQLALVFSLNDGNGHAITLGRQGRAFSRREGDLLRLVEPHVRAAVRRSLEAPDAYRVVHTRRQRVRWAVRSGPAIAAAGTAPALTGRELEVLALVAGGLSNQQIGRRLGLAPRTVDKHLENAFGKLGAHSRVEAVVNLRVRMAHVL
>NC_022657.1|WP_023358997.1|1294543_1295233_-|lytic-transglycosylase-domain-containing-protein
MKRLWSRIGIRLASVCLLATGLVGGIYLGQNASAEPGTAAPDVLQAEAADMQLLKLRQGAHAAARAQQRQAEGNAAERATAEARSAAAKGRKLEARAIAVKKAAAARKKALENGGPVPYAGPIPSSCNDYSGSRAIGCALMLDKGFGLDQFPCLDKLWKHESGWNYRAENRSSGAYGIPQALPGKKMSSSGADWKTNPATQIKWGLGYIKGRYNTPCGAWSNFQNNGNY
>NC_022657.1|WP_023358998.1|1295263_1296070_-|S-methyl-5'-thioadenosine-phosphorylase
MNERPPEAEIGVIGGSGLYALLDGATEHQVSTPYGEPSDPITVADVGGRRVAFLPRHGRDHRFPPHKIPYRANLWALRSLGVRQIIAPCAVGGLRPELGPGTFVVPDQLIDRTSGREQTFYDSGAVHVSFADPYCPDGRRAVLAAGETVSPVDGGTMIVVEGPRFSTRAESRWFTSIGGAIVNMTGHPEAVLARELALCYTAIALVTDLDAGVEGDHGVTQEEVFKVFADNTAKLRDVLLDAVGRLPAERTCSCRTALDGIKLPFDLP
>NC_022657.1|WP_023358999.1|1296195_1296753_+|YqgE/AlgH-family-protein
MESMTGQLLVATPTLKDPNFDRTVVLLVAHETGGALGVVLNRATEVPVADVLGNWGELAGDPAVLFEGGPVQPESAICLARTRPQVKKRVSGFHQVSGALGTVDLSADPDRLRDSVAGIRVFAGYSGWSPGQLEEEIAAGSWFVFDALPGDPFVSRPDDLWAMVLRRQGDILAAVAHFPPDVSLN
>NC_022657.1|WP_023359000.1|1296991_1297567_+|hypothetical-protein
MTTSAGSRTRFKASVFLSYPKPFMQRQQAFIERICGYLDDRGFSPRTLGVTDYDLDAPLKAVRRLMLESNGLITVAFRRTYIEKGTGNHRTDLSDRQSYEVDGRWTTSPWSQIEPAMAYQLGLPILILREEGVIPEGMLQRGVAGMYMPEFDLGTSLDDYFGSPEWNDVIFKWEAQVRTVVDRKGSPPKLY
>NC_022657.1|WP_023359001.1|1297581_1297875_-|hypothetical-protein
MKSRLRRLHLDGRVFTWKGEVRHAGTRRFIRVRAWGAGKNSRPLQADLHERPNQTYPYPTADDVRTLVTHALAAGWTPEAHGAAFVLTNVSLPAFTV
>NC_022657.1|WP_023359002.1|1297871_1300664_-|winged-helix-turn-helix-domain-containing-protein
MRFELLGPFRVRTPAGADVPLPPRHRALLAALLVADGHPMSAERLVAEVWPDGAPATAASALQVYVSGLRKAIGDRLRTTQAGYLLDVAGDTVDAREFERLLSSAGDRLVLLDEALALWHGPAFDGVAAGPAVHAAAARLTELLLAARREWGGLALAAGRTGEATAELTGWVAQHPASEPLVALLMLALHRTGRTAEALGVFARTESALADLGTRAGAELATLAEAVRRHDPTLTPPAPGLPGGRNRFIGRRAELDRAITLLGTGRLLTVAGPGGCGKTRISYEMTREVATEYPGGAYVVELAGLAAGSGAEALTAHVAAAVGAREAAGVPIAETLNRHLGSDRALLLLDNCEHVRADVAALVHGLLAACPGVRVVTTSREPLGLPGEIVLPLGGLALPAPGAPAREAARSDAVRLLADRVAAARGGTPLSAAEEPVAAELCRRLDGLPLALELAAARLRALSLTEVVSRLDRRLDLLVGQLPEGRHRTMRAAIDWGHDLLDEPQRIVLRRLSVFAGGFDLASAQQVGADPDGKAPHTGDAVLDPLLQLVDRSLLERTATTDVSRYRMIETIREYAAERLADESTDGESARARSRHAQLWADLLAPPPPVEGPAHAAWLATVGAEYDNIRAALLWTLDGDGDAELGLTIAAAMWWYWWITGRMLEGRSWLGRALEATPAEATPLRGRALRVAASLARNSGDLEAARALGEQGLATFRSLNDRAGVIAALNNLSITAQGQSDFAASLAYGNESLHLAAEDGNARAVAAAQNNTAGTLRCMGRLDEASALFTLALAGFRDITERRGEAAALANLSIVDRRLGRLTASRTGMIESLRLYTELEIAEGQVDAIEGLAQLAILEARPAEGLTLLAVAERERSTLGAPIFTPDEAADRDAAESAARTALTSSDIAAAYRSATATSLTAAVEAALRS
>NC_022657.1|WP_023359003.1|1300812_1301772_-|helix-turn-helix-domain-containing-protein
MKDLAVRLAALDADAGAALRVISYFDSLAEARAGLQPIVRGAAVLADCPARLLDPTRRVRIRVTQTGLADWRQEAPDETWMSVPAGTATLWLERPGPAGPVEAMILERAAGAARAVLDRTRGRAPATDPASVELIVDPSAPPDVRLQAARRLGLTDTGYVIALEGAIRVLSGPLPTLTGRAGIGPTTALLDLPTSWEAARTALRFAADGTEEDPGDQVVHAADLGGLALLATAGDQSALPDVKALEHAASAASWMLTTLHAVAASISLRAAATTLRIHHSTLQDRITHAENLLTWNVRDPQGRLRLQLALALRHLHRHR

Crispr_ID: NC_022657_7

• CRISPR_ID: NC_022657_7
• CRISPR_location: 2066745-2066848
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_022657_7

Consensus_repeat	Method
CGGAAAGGAAGCGGGACAGTCCGACGCAG	CRISPRCasFinder

spacers of NC_022657_7

>7.1|2066774|46|NC_022657|CRISPRCasFinder
GGCAGGGATACCCCGGTGTTGTGGTTGAGGGTGCCGCTGTGCGTAT

CRISPR arrays and Neighbor proteins around NC_022657_7

CRISPR arrays

The CRISPR arrays of NC_022657_7

>merge|NC_022657|7|2066745-2066848|CRISPRCasFinder
CGGAAAGGAAGCGGGACAGTCCGACGCAGGGCAGGGATACCCCGGTGTTGTGGTTGAGGGTGCCGCTGTGCGTATCGGAAAGGAAGCGGGACCGTCCGACGCAG

>NC_022657|7|6|2066745-2066848|CRISPRCasFinder
CGGAAAGGAAGCGGGACAGTCCGACGCAG	GGCAGGGATACCCCGGTGTTGTGGTTGAGGGTGCCGCTGTGCGTAT
CGGAAAGGAAGCGGGACCGTCCGACGCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023359829.1|2058534_2059335_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213231
NC_022657.1|WP_023359861.1|2075273_2076155_+|phosphotransferase	unknown	unknown	gnl|CDD|225213
NC_022657.1|WP_084298354.1|2056616_2057048_+|thioredoxin-family-protein	unknown	unknown	gnl|CDD|239245
NC_022657.1|WP_023359857.1|2073444_2074197_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NC_022657.1|WP_023359847.1|2068126_2068813_+|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl|CDD|226098
NC_022657.1|WP_023359845.1|2067145_2068096_+|ROK-family-glucokinase	unknown	unknown	gnl|CDD|273246
NC_022657.1|WP_041840733.1|2057151_2057703_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236608
NC_022657.1|WP_023359849.1|2068838_2070185_+|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl|CDD|109787
NC_022657.1|WP_023359841.1|2064465_2064918_+|SRPBCC-family-protein	unknown	unknown	gnl|CDD|176861
NC_022657.1|WP_023359827.1|2057699_2058503_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023359831.1|2059331_2060654_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_041841966.1|2062566_2064258_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NC_022657.1|WP_023359853.1|2070949_2072362_-|trehalose-6-phosphate-synthase	unknown	unknown	gnl|CDD|340820
NC_022657.1|WP_041840734.1|2072421_2073276_-|DUF308-domain-containing-protein	unknown	unknown	gnl|CDD|377113
NC_022657.1|WP_023359837.1|2061890_2062559_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NC_022657.1|WP_023359833.1|2060650_2061253_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023359835.1|2061328_2061742_+|DUF4395-domain-containing-protein	unknown	unknown	gnl|CDD|379566
NC_022657.1|WP_023359859.1|2074348_2075041_-|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223736
NC_022657.1|WP_023359851.1|2070181_2070961_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|225176
NC_022657.1|WP_023359863.1|2076171_2076666_+|polyadenylate-specific-3'-exoribonuclease-AS	unknown	unknown	gnl|CDD|374562

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023359829.1|2058534_2059335_+|ABC-transporter-ATP-binding-protein	gnl|CDD|213231	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	9.37446e-98
NC_022657.1|WP_023359861.1|2075273_2076155_+|phosphotransferase	gnl|CDD|225213	COG2334, COG2334, Putative homoserine kinase type II (protein kinase fold) [General function prediction only].	4.58488e-21
NC_022657.1|WP_084298354.1|2056616_2057048_+|thioredoxin-family-protein	gnl|CDD|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	1.79816e-12
NC_022657.1|WP_023359857.1|2073444_2074197_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	9.40172e-54
NC_022657.1|WP_023359845.1|2067145_2068096_+|ROK-family-glucokinase	gnl|CDD|273246	TIGR00744, Glucokinase_Glucose_kinase., ROK family protein (putative glucokinase). This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General].	2.10368e-78
NC_022657.1|WP_041840733.1|2057151_2057703_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236608	PRK09652, PRK09652, RNA polymerase sigma factor RpoE; Provisional.	1.58308e-32
NC_022657.1|WP_023359849.1|2068838_2070185_+|NAD(P)-binding-domain-containing-protein	gnl|CDD|109787	pfam00743, FMO-like, Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.	4.92515e-69
NC_022657.1|WP_023359841.1|2064465_2064918_+|SRPBCC-family-protein	gnl|CDD|176861	cd07819, SRPBCC_2, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	7.74873e-44
NC_022657.1|WP_041841966.1|2062566_2064258_-|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	4.78166e-44
NC_022657.1|WP_023359853.1|2070949_2072362_-|trehalose-6-phosphate-synthase	gnl|CDD|340820	cd03788, GT20_TPS, trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.	0
NC_022657.1|WP_041840734.1|2072421_2073276_-|DUF308-domain-containing-protein	gnl|CDD|377113	pfam03729, DUF308, Short repeat of unknown function (DUF308). Family of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X (#=hydrophobic).	0.000499213
NC_022657.1|WP_023359837.1|2061890_2062559_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.69135e-65
NC_022657.1|WP_023359847.1|2068126_2068813_+|endonuclease/exonuclease/phosphatase-family-protein	gnl|CDD|226098	COG3568, ElsH, Metal-dependent hydrolase [General function prediction only].	5.05776e-25
NC_022657.1|WP_023359835.1|2061328_2061742_+|DUF4395-domain-containing-protein	gnl|CDD|379566	pfam14340, DUF4395, Domain of unknown function (DUF4395). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 142 and 168 amino acids in length. There are two completely conserved C residues that may be functionally important.	6.05998e-35
NC_022657.1|WP_023359859.1|2074348_2075041_-|Crp/Fnr-family-transcriptional-regulator	gnl|CDD|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.10332e-37
NC_022657.1|WP_023359851.1|2070181_2070961_+|alpha/beta-fold-hydrolase	gnl|CDD|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	1.00341e-09
NC_022657.1|WP_023359863.1|2076171_2076666_+|polyadenylate-specific-3'-exoribonuclease-AS	gnl|CDD|374562	pfam16473, DUF5051, 3' exoribonuclease, RNase T-like. This is a highly divergent 3' exoribonuclease family. The proteins constitute a typical RNase fold, where the active site residues form a magnesium catalytic centre. The protein of the solved structure readily cleaves 3' overhangs in a time-dependent manner. It is similar to DEDD-type RNases and is an unusual ATP-binding protein that binds ATP and dATP. It forms a dimer in solution and both protomers in the asymmetric unit bind a magnesium ion through Asp-6 in UniProtKB:P9WJ73.	3.64384e-13

Protein sequences

>NC_022657.1|WP_023359841.1|2064465_2064918_+|SRPBCC-family-protein
MADTSTQSIQVHAPLAQVAAVICDFPRYPEWADAMKKVEVLEEYEDGYAAQVRFVIDAGPLADDYTLDYAYAEDLSRIEWHLVAPSKMQKTLNGSYDLADNSDGTTTVTYMLEVELSIGMLGMFRRKAEKMIMDTALKELKRRVESLAKA
>NC_022657.1|WP_041841966.1|2062566_2064258_-|sensor-histidine-kinase
MPASASVPVRVHPLAVGARLVMLALVAALTLIATHEVGQLRWIALLLVAALPAFFAPDHRIAAPLGRFAEVAITGLAAGSVAVAASTTGTVSAGFGAEAILPYLAVPLLTAALRRRPTEGAALLGVAAVAMVIGGILVGDGDKMITQAGYLAAGGQWLVTGAIVTFAADTMRQLMTPVEDKPQPYAEATRLLTQLRSVARSLPGATLDPGGISEHLLEELRAVAPGHRAAVLSASGGGRLVVLAQTGAERVDWEVTLDADSAIADAWASQQPHTASRSQARSHKGGDASSLVVPLVAGVRTIGLVILEADVASAYPKAVVARVTEVTGPAALRLEAALLFDDVRSLATNEERQRLAREIHDGVAQELVMVGYGIDNATATLPEGAEETAEELATLRGEVTRVITELRLSLFELRSEVDRNGGLAAAIAEYARTLGTSAGLRVHFTFDESTARLPAATEAELLRIAQEAITNARKHAGASNLWVTCTVDPPYAEIEVTDDGKGFADDRPDGRYGLAIMAERAERIRGRLEIRPRHPSGTTVAVVLGTSSRRDSVRDSVSAPEGE
>NC_022657.1|WP_023359837.1|2061890_2062559_-|response-regulator-transcription-factor
MSTSPMPTTRTKVLLVDDHDLIRKGLRHAFERDRQFEVVGEAATAAEAVRQAGALQPDVVIMDLRLPDGSGLEATRALRKNNANMGIVVLTMYAGDDQLFGALEAGASAFVPKTAPADEVVAAARHAASAPSAFTAADLAEAMKRRLAPSGPQLSPREGQVLRLLADGMSVAGIAKQLFVSESTAKTHISKLYEKLGAANRAQALMTALRLGLLEAPDAPKF
>NC_022657.1|WP_023359835.1|2061328_2061742_+|DUF4395-domain-containing-protein
MQLDPRGPRFAAGLTTVVLVVVLTTGWGWLALAQTVVFAITAADPRHGPYAFVYRFLVAPRLGPTTEREDAAPVRFAQLVGFAFLAVASIGYLSGATALGVVSAGFGLLAAFLNAAFGLCLGCEAYLAARRLSAGRA
>NC_022657.1|WP_023359833.1|2060650_2061253_+|hypothetical-protein
MRWLTLYLRSRRVPVALAVVGGITALMWTLWSVFSNTREAGLPLVVLTVLVLVATLTATLAGPDDALERTAALRWPPRRAAHLLGGLAVILVLLYATLLTGARFGPAGLVLRDAAGLLGLTALGSVTIGTAKAWCAPLGWTLIAIMFPQPGEGAGQVLTWQTQAPDNRAAAVTAALLTLSGLIAYAVAGPSRRAPAEAAL
>NC_022657.1|WP_023359831.1|2059331_2060654_+|hypothetical-protein
MSRVLGIELRRSAAAGAGLALLVVGVLLLFFAEGIDFSTGWVQLAMTQRLYLAVLWPLALAAGAFQGRRDHRSNVTELFSTTPRPRMHRTMPTLGAMAISVVCAYLVMGIAGGLWIITTAEYFPVTVFVVTAVGALALIAAAWFGLAIGRLLPSIITAPALGVAGLALLLLIPMATRPRGWLALVFSPIYEMNMPGAYATVPTRVSISQTLWLIGLAVAGVLLFASSGWRVRVAALLPLVAGAALAITVMPHQNRYVTDALDPVAQELVCTEDEPRVCVSRVHSALLGEVTPRAREALQILAKLPGAPTQAHEDTTYYPDSFPPRRTDTVLIPVEADDKGHLADPDTVVPRMLDAAGANGIGCEQPADLVVTRAAGSWISGREPVATYEYEDPSINPAAVQLWEKLRSLPEADAAARVSAVRQAVLACKDVKGLLDRSAG
>NC_022657.1|WP_023359829.1|2058534_2059335_+|ABC-transporter-ATP-binding-protein
MRTVSAAETAPTTHPWAVHAQGLRVRAGRHLAVDGLDLALGTGVHGLLGPNGAGKTTLMRALATVVKPAGGQLTMLGETVDGRADLRRIRRGLGYLPQAFGFYPRFTVREFVEYMAWLKEMPKTAVPGAVQRAIDRVGLTAKANARMKTLSGGMLRRAGIAQAIVNDPEVLLLDEPTVGLDPEQRLDFRELLRDLGVDSCVLVSTHLVEDVVAACTDVVLINEGKLVHQGTPDTLIAQGGQSDAGDSPAERGYSALLRRHRAEGNR
>NC_022657.1|WP_023359827.1|2057699_2058503_+|hypothetical-protein
MTTHPSLAVITRYAEGDERLDDATVWSVEVHLETCVGCRAQLAGAATDDTRLLLERVAAELDGGITAGPAPVRVHRVWNALQRRWLVWALLPWLFMTVAVLGCAYLLELARPDLPSLVLLLAPVAPLPAVAVAWSRRADPAWELIAGAPAAGLTMLLRRTATVLAVLVPALALVGARSGASLALVLLPSLSFTAATIALGAVVGVQRAAIGLGVAWVAAVVLPSFFTTRLPVVLHSESVPVWALVTVALAAFAATRSAGYRRLSSRD
>NC_022657.1|WP_041840733.1|2057151_2057703_+|sigma-70-family-RNA-polymerase-sigma-factor
MRRSQETADEEELVRRTARGDRRAFDELYRRTSPWLAVRLRRRCADEDVVADVLQETYLSVWRAAGSFAGAATQGSAVGWLWTIAANRLVDAFRRRARQAQVPAVPLTAMTAPAAEEEVMAGRVEQNLETALLALPPEMRQVLRAMVLDGLSVRETALLLEVPEGTVKSRARRARIALREALS
>NC_022657.1|WP_084298354.1|2056616_2057048_+|thioredoxin-family-protein
MHHSASASAVPEVVGESTVIAGVPAGTGDGADPSAAGERLDPALLKTLGVGPAPATLLQFSSAFCAPCRALRRVSGEVVALLPDVQHVEVDAESHLDVVRALGIWRTPTLLVLDADGRVSKRATGVPGKAQLIAALGDLLPAR
>NC_022657.1|WP_023359845.1|2067145_2068096_+|ROK-family-glucokinase
MTLTIGVDVGGTKVAGGVVDDLGVVLTQIRRETPADDPAGTRDTIVAVAAELAAAHPEAKAVGIGAAAWIDAAGATVLFAPNLAWRDEPVRDYVAKAVGLPTVLENDANVAAWAEFRYGAARQADDSMVMITVGTGIGGGIVLNGGLWRGANGIAGELGHIQSVNDGHPCGCGRLGCLEQYASGNALVRFARAGARQEPDRAGQLLELAGGDALAITGRMITEAAHGGDGVARDAFAQIGYWLGVAMADLAQAFDPQVLVVGGGVIDAGELLMGPTERTYRDQLAQRGRFPVAEIKAAETGNTAGVLGAADLARRI
>NC_022657.1|WP_023359847.1|2068126_2068813_+|endonuclease/exonuclease/phosphatase-family-protein
MSGVPLRVLSYNVHGLRDDRAALTGLVRDLAPDVVIVQEAPRRFRWRHKCAALASDFGMVVAAGGLPSLGNLLLVSLRVRVHDSWALRYPLTPGRHLRGAAFARCSVHGGRFTVSGSHLATDSVERPDQAARWTEALAAVEGPLIAGGDLNEGPGGGAWRTVADGFSEAAGAASPALTFPATLPRLRLDALFVTPDITVNRYEVVETDEARRASDHLPVLAELTLPSE
>NC_022657.1|WP_023359849.1|2068838_2070185_+|NAD(P)-binding-domain-containing-protein
MQDTPDIADRHDAVCVIGAGGSGLAAIKNLREQGFSVDCYERETSVGGAWNWRHDRSPVYANTHLISSRPLTEFPDFPMPDDWPDYPHHSQLLGYLERYAKHFGLGDSIWFGTEVVAVTPVGDGRWDVTTRSTGGGAERIQRYAAVIVANGHNWSPKPLSVDTSAYRGKVMHASAYKDPAQLRGRKVLVIGGGNTGCDIAVEAAQQATTVWHSTRRGYWYAPKYIFGRPADQVNDKMLQLRLPLRLRQWLYHRTLRLTVGDVTRFGLPAPDHRPYESHPVVNSQLVYYLGHGRITPLPDVARLEGSTVELADGRRIEPDLVITATGYLPRFEFLAPELLDIDEDGKPDLHLHAFARKHPTLAVVGLVQADAGLFPLAHWQSVAVARWLRLRVSDPVRATAVQQKESTRPLRSWTRLRVVPSSRHWFEVSHTSYLRTLEDLLKQMEPVA
>NC_022657.1|WP_023359851.1|2070181_2070961_+|alpha/beta-fold-hydrolase
MSPQLLRFADWTAPVTAVEREVLHALPESPSDESPPVLFVPGLGHGAWAFAEHWLGHTASRGFAAHAVSPRADGSLRAYVHDVVQVAASLPRQAVLVGHGAGALVVSHALARYPARAAVLASPVPAGWAAVGAALRANPLGTLPALFGAAPRLSRKQLFSAGLAEGEAYQERLVRAPARVYRQVLFAKPAAEPVGAPPTLVVGSPDDRVVPRAALDRAAARFGGAPLLFPGMGHDLMLDTDWREPIDAILDWLGKELAS
>NC_022657.1|WP_023359853.1|2070949_2072362_-|trehalose-6-phosphate-synthase
MRQSSLVVVANRLPLDDNAAPDGACEWRRSPGGLASALHAILQQTPATWIGWNGGIDSAPVLPDVGTLRIRPVSLSSEELQGYYEGFANSTLWPLYHDAVEQPVFDRGWWETYRAVNQRFAEAAAELAEPGAAIWIQDYHLQLVPQLLRELRPDVLIGFFLHVPFPPPELFMQLPRRAELLRGMLGADLVGFQRPQAAHNVAQLAVKLFGAEATDDQITLDGRTVRTGAFPVSIDVTEMQALASRPDIVEHAEQLRADLGQPRRVLLSVDRLDYTKGIEHRLTAYSELLRDGRVKVRDTVMVQVAVPSRERVDSYRVLRDRIEGEVGRINGEYGRVGEPAIHYLNQSFDRADLAALYQTADLMVVTPLRDGMNLVAKEYVAARSDNSGALVLSEFAGAAAEFEDAFLVNPHDVDGLKETLLQAMDADPADLQRRMAAMRDQLQRHDILAWARTYLTALDHTGRLAAGLRR
>NC_022657.1|WP_041840734.1|2072421_2073276_-|DUF308-domain-containing-protein
MSAGGARRGRRDNGLDAADYAVAGDVDPRVGEHLLDVLAAGGIAAYLQPSADLNPILRATTFPARPTDRLYVDRTHLATAREHLDKLTGGVGPTPPAPRPDTRTEAGGDQTDVDAEWAKIVAGFHTAVDPTAPPWPAAEGVDPTRAPDLPKNETPDPPRQPGGTLPSAADFSGVSLNRRRTDEPSLLDGLDTFGTGTDDDSDEDDERYTPPPPPPLPHISKYAVAGILGVVLGFVLFLFPWLLPIERNFVTLIGFTAIVGGAVTLVWRLRSGDDDDDFDDGAVV
>NC_022657.1|WP_023359857.1|2073444_2074197_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MFYWLLKYVVLGPVLKCVFRPDVQGLAHVPRSGPVILACNHLSFSDSIFTPLLVKRRVTFVAKAEYFTGKGIKGWLMRQFFVSTGTIPVDRSGGKAARAALDTQLRVLRSGNIAGIYPEGTRSPDGRLYRGKTGVARLALESGAPVVPVALLNTDEIQPTGKLIPKIKRVKIRFGEPLDFTRYAASAGDRFVERAVTDEIMYELMTMTGRPYVDVYAASLKTAIVAPTPTPEGRTQSRTAPVGVEGAEKD
>NC_022657.1|WP_023359859.1|2074348_2075041_-|Crp/Fnr-family-transcriptional-regulator
MDHRLAEQGDALTGVEMFAGLEPDVRQRVIAAAVPRTYRKGQILFVEHDPGDSLIILRRGAIAVFRTAPTGERAVLTVVRPPDVLGEVSLLDALTRSASAEAIEDSQALALSRVAFIDLVHSNPRILDAVMRSVGALIRRLTEQNADHVFLDLPGRVAKTLVRLAGESQAPMITIELNQSQLAEMAGGSRQSVNQAIGSFASRGWLRTEGRRIVVTDVSALRRRAGMADR
>NC_022657.1|WP_023359861.1|2075273_2076155_+|phosphotransferase
MPDDDLLRSTLRDQWHLVPAEISALPGGLLSHGWDVTAGGERFVARLADPASRQPVEAGLAAAEHLRGTGIEAGEPVRTLAGGLTAETSAGALAVLRRAPGRTLDGRDPIDQQFWGDRLGAVHSRLQGFHHPGLRRWNLLDPDAAHLAIEPWLRPAVTDAVAAMTRLTVTDRLTYGVLHGDPAPEIFLVDPATGRAGLLDCGASGTGPLLYDVAAAVVYAGGTETSAELLDGYLAAGPVDEGELHAALPVLLRFRWAVQADWSAQRLVRGDPGGAREALARAREALAEPPTAA
>NC_022657.1|WP_023359863.1|2076171_2076666_+|polyadenylate-specific-3'-exoribonuclease-AS
MAYRYFYDCEFIEDGRIVDLVSIGVVDEFGREFYAVSTQFDDTRAVPWVRRNVLDKLPSPSDPAWRSRERIRDDLYEFLREPVKGRDEQIELWAWYAAYDHVALAQLWGAMPALPREIPRFTKDLRQLWDDLGKPTLPTAQGRHDALVDAKHNLARWNTMKSKA

Crispr_ID: NC_022657_8

• CRISPR_ID: NC_022657_8
• CRISPR_location: 4506924-4507029
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_022657_8

Consensus_repeat	Method
CCATGCAACCAGGCACGACATGGCCT	CRISPRCasFinder

spacers of NC_022657_8

>8.1|4506950|54|NC_022657|CRISPRCasFinder
CGATTTTGATCTTCAAGAAGCTCCGCCCTTTCTCGGCGGGAGCGACGGTCAGAG

CRISPR arrays and Neighbor proteins around NC_022657_8

CRISPR arrays

The CRISPR arrays of NC_022657_8

>merge|NC_022657|8|4506924-4507029|CRISPRCasFinder
CCATGCAACCAGGCACGACATGGCCTCGATTTTGATCTTCAAGAAGCTCCGCCCTTTCTCGGCGGGAGCGACGGTCAGAGCCATGCAACCAGGCACGACATGGCCT

>NC_022657|8|7|4506924-4507029|CRISPRCasFinder
CCATGCAACCAGGCACGACATGGCCT	CGATTTTGATCTTCAAGAAGCTCCGCCCTTTCTCGGCGGGAGCGACGGTCAGAG
CCATGCAACCAGGCACGACATGGCCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023362778.1|4505809_4506505_-|TetR-family-transcriptional-regulator-C-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|224228
NC_022657.1|WP_023362783.1|4509797_4510673_+|5-deoxy-glucuronate-isomerase	unknown	unknown	gnl|CDD|275171
NC_022657.1|WP_023362777.1|4505203_4505347_-|hypothetical-protein	unknown	unknown	gnl|CDD|378795
NC_022657.1|WP_084298404.1|4504419_4505019_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
NC_022657.1|WP_023362786.1|4514044_4514944_+|TIM-barrel-protein	unknown	unknown	gnl|CDD|275172
NC_022657.1|WP_023362775.1|4503696_4504287_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379228
NC_022657.1|WP_023362773.1|4501536_4502184_+|GPP34-family-phosphoprotein	unknown	unknown	gnl|CDD|377552
NC_022657.1|WP_023362787.1|4514967_4515963_+|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|380535
NC_022657.1|WP_023362781.1|4507985_4508939_+|5-dehydro-2-deoxygluconokinase	unknown	unknown	gnl|CDD|275175
NC_022657.1|WP_023362785.1|4512538_4514035_+|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|143404
NC_022657.1|WP_041841021.1|4516033_4517104_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224093
NC_022657.1|WP_023362782.1|4508931_4509801_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023362784.1|4510669_4512523_+|3D-(3,5/4)-trihydroxycyclohexane-1,2-dione-acylhydrolase-(decyclizing)	unknown	unknown	gnl|CDD|275170
NC_022657.1|WP_023362771.1|4498730_4499942_-|DUF1501-domain-containing-protein	unknown	unknown	gnl|CDD|226587
NC_022657.1|WP_063749620.1|4502254_4503700_+|APC-family-permease	unknown	unknown	gnl|CDD|223605
NC_022657.1|WP_023362772.1|4499956_4501210_-|DUF1800-domain-containing-protein	unknown	unknown	gnl|CDD|378055
NC_022657.1|WP_023362789.1|4517106_4517922_+|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224053
NC_022657.1|WP_041842485.1|4497897_4498659_-|dioxygenase	unknown	unknown	gnl|CDD|153375
NC_022657.1|WP_023362780.1|4507050_4507812_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225099
NC_022657.1|WP_023362779.1|4506638_4506878_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023362778.1|4505809_4506505_-|TetR-family-transcriptional-regulator-C-terminal-domain-containing-protein	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.11226e-08
NC_022657.1|WP_023362783.1|4509797_4510673_+|5-deoxy-glucuronate-isomerase	gnl|CDD|275171	TIGR04378, Myo-inositol_catabolism_IolB_domain_protein, 5-deoxy-glucuronate isomerase. Members of this protein family, 5-deoxy-glucuronate isomerase (iolB), represent one of eight enzymes in a pathway converting myo-inositol to acetyl-CoA. [Energy metabolism, Sugars].	1.77321e-115
NC_022657.1|WP_023362777.1|4505203_4505347_-|hypothetical-protein	gnl|CDD|378795	pfam12029, DUF3516, Domain of unknown function (DUF3516). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is typically between 460 to 473 amino acids in length. This domain is found associated with pfam00270, pfam00271.	4.63389e-08
NC_022657.1|WP_084298404.1|4504419_4505019_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	4.49228e-11
NC_022657.1|WP_023362775.1|4503696_4504287_+|GNAT-family-N-acetyltransferase	gnl|CDD|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.50739e-08
NC_022657.1|WP_023362773.1|4501536_4502184_+|GPP34-family-phosphoprotein	gnl|CDD|377552	pfam05719, GPP34, Golgi phosphoprotein 3 (GPP34). This family consists of several eukaryotic GPP34 like proteins. GPP34 localizes to the Golgi complex and is conserved from yeast to humans. The cytosolic-ally exposed location of GPP34 predict a role for a novel coat protein in Golgi trafficking.	1.01096e-27
NC_022657.1|WP_023362787.1|4514967_4515963_+|substrate-binding-domain-containing-protein	gnl|CDD|380535	cd06312, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of uncharacterized ABC-type transport systems. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	1.1011e-91
NC_022657.1|WP_023362781.1|4507985_4508939_+|5-dehydro-2-deoxygluconokinase	gnl|CDD|275175	TIGR04382, myo-inositol_catabolism_protein, 5-dehydro-2-deoxygluconokinase. All members of the seed alignment for this model are translated from the iolC gene of known or putative inositol catabolism operons. Members with characterized function are 5-dehydro-2-deoxygluconokinase, the enzyme catalyzing the fifth step in degradation from myo-inositol or closely related compounds. Note that many members of this family are fusion proteins with an additional C-terminal domain, of unknown function, described by pfam09863. [Energy metabolism, Sugars].	8.99696e-150
NC_022657.1|WP_023362785.1|4512538_4514035_+|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase	gnl|CDD|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0
NC_022657.1|WP_041841021.1|4516033_4517104_+|ABC-transporter-permease	gnl|CDD|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	3.7724e-62
NC_022657.1|WP_023362786.1|4514044_4514944_+|TIM-barrel-protein	gnl|CDD|275172	TIGR04379, myo-inositol_catabolism_protein, myo-inosose-2 dehydratase. Members of this family include the enzyme myo-inosose-2 dehydratase, product of the gene iolE, as found in inositol utilization cassettes in many species. [Energy metabolism, Sugars].	1.27135e-44
NC_022657.1|WP_023362784.1|4510669_4512523_+|3D-(3,5/4)-trihydroxycyclohexane-1,2-dione-acylhydrolase-(decyclizing)	gnl|CDD|275170	TIGR04377, 3D-35/4-trihydroxycyclohexane-12-dione_hydrolase, 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase. Members of this protein family, 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (iolD), represent one of eight enzymes in a pathway converting myo-inositol to acetyl-CoA. IolD hydrolyzes the cyclic molecule 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione to yield 5-deoxy-D-glucuronic acid. TPP is a cofactor. [Energy metabolism, Sugars].	0
NC_022657.1|WP_023362771.1|4498730_4499942_-|DUF1501-domain-containing-protein	gnl|CDD|226587	COG4102, COG4102, Uncharacterized protein conserved in bacteria [Function unknown].	4.26273e-57
NC_022657.1|WP_063749620.1|4502254_4503700_+|APC-family-permease	gnl|CDD|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.45684e-26
NC_022657.1|WP_023362772.1|4499956_4501210_-|DUF1800-domain-containing-protein	gnl|CDD|378055	pfam08811, DUF1800, Protein of unknown function (DUF1800). This is a family of large bacterial proteins of unknown function.	1.95614e-106
NC_022657.1|WP_023362789.1|4517106_4517922_+|sugar-ABC-transporter-ATP-binding-protein	gnl|CDD|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	6.61843e-93
NC_022657.1|WP_041842485.1|4497897_4498659_-|dioxygenase	gnl|CDD|153375	cd07363, 45_DOPA_Dioxygenase, The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine. This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.	8.52062e-98
NC_022657.1|WP_023362780.1|4507050_4507812_-|GntR-family-transcriptional-regulator	gnl|CDD|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	7.80628e-63

Protein sequences

>NC_022657.1|WP_023362779.1|4506638_4506878_+|hypothetical-protein
MDDGWYRLGMLLTLAAGIWEGPIAIIFRAFTDKKPTVLTAANYLPAPWCYLAAVAAAAAAFAVIAALETRRRKATAEPR
>NC_022657.1|WP_023362778.1|4505809_4506505_-|TetR-family-transcriptional-regulator-C-terminal-domain-containing-protein
MCRGPLRVVVRGRRPVYCSRACQARAYRARKNPPAPEAPELSGRRRQIVEAVWRIAAGRGLQMATIREIAAEAGVTPRVVQYHFTDKHHLLVTALQTLHRDNEQHSRRRIAALRDPSDPRVLLRATLEELLPLDEQRRTSLRVLTAYYAWSLTDPALAAVFLHGEHPLEDLVTALITAAGARPSIDPAEEANLLVGGLSGLGLDLLHRRRTRTDVQRTLDHHLNRILSPHP
>NC_022657.1|WP_023362777.1|4505203_4505347_-|hypothetical-protein
MKRTLARAGDDPKKPPEGTIGWGQLTFDRPAGPAYHHPARHLFLGRW
>NC_022657.1|WP_084298404.1|4504419_4505019_+|class-I-SAM-dependent-methyltransferase
MGAESVLDVGCGTGAMLHHAREAGHRGTLAGIDPNSAFLERARRRDDIEWVFGTAAAMPWEQEFELAVMTGHAFQCLIGDGEIRASLAGVRAALHEGGRFVFETRHPQARAWETWTPSHAVEVAGVRVVHQVESVVGDVVTFTETAYATERHVLRFLDLPVLNTLVTQAGFHIDAQYGDWHGGPLTPASTEIITVAVRH
>NC_022657.1|WP_023362775.1|4503696_4504287_+|GNAT-family-N-acetyltransferase
MTPTIRPARESELTDVGRLVALSFDDLEQNRSLVPDPSARLRVMGDFFTMLTVHAPLCGKVDVIDAPDGSLAAAAVWFDRTREMPEIPDYDERLAALAGEWLPNFEALDEVFDKHHPVDPHWHLAFLAVHPSHQSHGLGGALMDSTHEDLGRTPAYLEATNDNNIRLYRRHGYTEMLPFDIRLPDNTPFYRMWRAA
>NC_022657.1|WP_063749620.1|4502254_4503700_+|APC-family-permease
MARDRLGVAAVVFFVMSAAAPLTVVAGVVPTGLAVTGLTAISIAFLAVAIVLAVFAVGYVAMARHIANAGAFYAYIARGIGRPFGVGASWVALLAYNSFQVASYGGFGAIAAPLFADWFGVEIQWWIIALAAWALVAVLGVRDVAVNGKVLATLLVAEIVLVVVFSIADLMAPDFAASSAPVDPSSLVGAGAGALLVMAVTGFVGFEQSVVFSEESRDPRRTVPRATYIAVALIAVLYAFSSWAMISATGGKAVERAGAEGPELFFNLASDRLGSTALHLGHALFLTSLIAAMISFHNIIARYTFSLGREGVLPRAFGRTVPGTGAPKNGSLAQSVLGLVVIGVYAIAGWDPLVQLFFWGGTTGGIGVLLLITVTSAAVVGYFARNPEGEDFWHRLGAPVLGTVLLLVVTYLALTNIEILFGVEPGSTPTWAVPLAYAVLTLAGVTWALILRRTRPGTYQGIGMGARSGFSIRDTATEAHQ
>NC_022657.1|WP_023362773.1|4501536_4502184_+|GPP34-family-phosphoprotein
MATSQLPLADDLYLAAHDNARGRCLLSPATLGLGLAAGLLAELVLWRRLEIQDAGLTVVDERPTAEAATSAVLEQLLREGHHRQVRDWIAFLATGVATELVERRLARAGLVKRHEKRGLLGTKVRFVPTDLTVAGWPGTRIRIAATRGELLDSPDLVLTGLVLATGLDQHVLVTLEAAEREHLFGQLRRRLPVMLQHLVGQAEAAVGDAVMARRA
>NC_022657.1|WP_023362772.1|4499956_4501210_-|DUF1800-domain-containing-protein
MTDRTRVSHLLRRLTFGPTATEVDEAERTGADATLTRVLAPIGRTVGLPGLEAAAKPPEGASREERQKARQQARAQLMTATRWWLSRMVTEPGAAEKLTFFWHGHWATSSQKVRSAPLMLAQQQTFRRYGGGPAGPLVRAMVRDPALILWLDGQKNTRKAPNENLARELMELFTLGVGNYGEADVKAGARVLTGWQVDRAAGTAKLLPRRHDTTEVTLLGSTGRFDVDSYADLLVRHPAHAPFLAQRLWVRYGSDTGPAPQGVAAAAPDGTTAMLRALATDPAFAATAGQLVKQPIEWVIGAVRQLGVEDVPLAALKALGQVPFRPPSVGGWPVGPAWLTTSSTQARLKHGQALTAKAPAAVETLADVAQGDRVEALARLLVVDTWTNRTNTVLQDAAREPRRLLALGLASPEYAVH
>NC_022657.1|WP_023362771.1|4498730_4499942_-|DUF1501-domain-containing-protein
MDTITRRKFLTASGVVAAGALAAGGSAYALRDILATSGQRDPGKILVLVTLYGGNDGLNTVIPYADPAYAAARPGLTYDEGQVLRLEDGFGLNPGLKGLHKLYGEDRLAIVRGVGYPKPDRSHFRSMDIWQTASPERPGTTGWLGRWLDTAGRDPRLAVSFEPVLPPVLAGATSAGATVPGGALTLPQGVTPPVLDGFGTPAAGESPAQARAAACFADLVRVQGLMTDVAAEAEDDDEPEGQATATGGQAPPLDQQLALVTRCVEAGAATRVYSVSLGGFDLHADEKTAQEALLAKLDKPLAAFVERMAGREVVVAVYSEFGRRVHANASDGTDHGTASSVFLLGDGIKGGLYGEAPSLTDLDDGDLKHTTDFRDVYAMLLADVLDADPGRILDGWDGRFDFS
>NC_022657.1|WP_041842485.1|4497897_4498659_-|dioxygenase
MPALFISHGAPPLVDDPTWVAQLKDLTAGLPTPKAILMASAHWESAPLMLGATETVPLVYDFGGFPRHYYEVQYRAPGAPELADRIEKLMPDSERVTRTDRGLDHGAYVPLTVMYPDADVPVLQMSLPTLEPDRLLEIGRRLAPLRDEGVLIVGSGFTTHGLPFLRDWRTDAKAPGWSKEFDAWTAETLARGAVDELADFRNRAPGMPYAHPTIEHMAPMFLTLGASTDPEQSPDQPIDGFWMGLSKRSFQVA
>NC_022657.1|WP_023362780.1|4507050_4507812_-|GntR-family-transcriptional-regulator
MASDLSPPRSPVRPVEVDRTSPVPLYFQVATRLQELIEQGEIGVGARIENEVDLAERLGVSRPTTRRAIQYLVERGMLVRKRGVGTQVVHPKVRRPVELSSLYDDLVTSDRKPRTEVLDLRVIPAPADVAEALELPPGTEVTWIERLRYAGGEPLALMHNAIPLDVIRLEAADLAGHGLYELLRRAGFVPRIATQIIGARSAAAEARTLDEKRGASLLTMTRTAWDASGRALEYGSHLYRASRYSFELNLSAG
>NC_022657.1|WP_023362781.1|4507985_4508939_+|5-dehydro-2-deoxygluconokinase
MPADEVLTMGRIGVDLYPQQIGVSLREVRTFEKFLGGSPTNVAVAAARYGRRSAVISRTGADPFGEFIHDALRGFEVDDRFVTPVEGLPTPVTFCEIFPPDDFPLYFYRFPKAPDLEIFESELDLEAIRRADIFWVTGTGLCQSPSREATLAALRARDKAGITVLDLDYRPIFWESREEARSWVQQALPYVTVAVGNLDECETAVGVREPHAAARALHDAGVDLAVVKQGPLGVLASSRKEEVQVPPVPIEVVNGLGAGDAFGGALCHGLLAGWDLETTMRFCNAAGAIVATRLSCADAMPTESEVRELIGGVSGRA
>NC_022657.1|WP_023362782.1|4508931_4509801_+|hypothetical-protein
MRDVLEIVAARADRPGAIASAAAARRRPAGWRGEHGRMMIIAADHPARGALRAGPDPLAMGNRADLLDRICTALERPGVNGVLGTPDILEDLLLLGALDDKVVIGSMNRGGLAGTSFEIDDRFTAYDGDSLAAAGFEGGKMLLRIDPDDAGTVATLQACGRAVGDLAAHQLMAMVEPFISHRADGRVRNELSPEAMIRAMTVAAGLGTTSAYTWLKVPVVDDMERVMAATTLPALILGGEVSQDADAAYVRWSKALALPTVQGLVIGRSLLYPPGGDVAGAVDRAVSLL
>NC_022657.1|WP_023362783.1|4509797_4510673_+|5-deoxy-glucuronate-isomerase
MTLLRRGTAGSAPFETVVTPESAGWGYSGLRILDLPIGSRVSFGTGDEEMIVLPLTGGCDVTCDDERVTLTGRRSVFSRVTDFAYLPRDSAVTVRAPNGGRFALPAARADRRLPFRYGPADEVPVELRGAGQASRQVNNFCTPDSFDADRLIAVEVLTPGGNWSSYPPHKHDEPGENETALEEIYYFEVAGSPSGSPGTGFQRVYGHTDHPIDICAEVRAGDVVLIPYGWHGPSMAAPGYDLYYLNVMAGPGERKWLFSDDPEHAWIRGTWSQQEIDPRLPLTSTSERKRS
>NC_022657.1|WP_023362784.1|4510669_4512523_+|3D-(3,5/4)-trihydroxycyclohexane-1,2-dione-acylhydrolase-(decyclizing)
MRLTVAQAVVTFLANQWTERDGVEQRTIAGCFGIFGHGNVAGVGQALLQAQRTGSADLPYHLARNEQAMVHAAVGYARMKNRLSTMACTASIGPGSTNMLTGAALATVNRIPVLLLPSDVFATRVASPVLQELEDPRSYDVSVNDAFRPLSRFFDRVWRPEQLPSALLAAMRVLTDPVETGAVTLCLPQDVQAEAFDFPEALFEKRVWHVARPVPEPVAVERAAEVIRSARRPLIVAGGGVIYSEASAELDAFARATGIPVADTQAGKGALSWDHPNSVGGVGSTGTPVANALARDADVVIGIGTRYSDFTTASRTAFAAQDVRFVNVNVASFDAAKQSATPLVADARSGLTSLSAALAGYKSDMSYQADVAAWQRRVDEAYHLGHGPLPAQSEVIGAVNDACGERDVVVQAAGSMPGDLQLLWRARDPKQYHVEYGYSCMGFEIAGALGIKMADPGREVYALVGDGSYLMMAQEIVTAVSDGIKLIIVLVQNHGFASIGALSESLGSQRFGTSYRYRGADDDYDGATLPVDLAANAESLGANVIRCRTIADLTEGLKQARESDRLTVVHIETDPLSPVPSSESWWDVPVSEVSELDSTRDARTAYDAAKRGQRLYL
>NC_022657.1|WP_023362785.1|4512538_4514035_+|CoA-acylating-methylmalonate-semialdehyde-dehydrogenase
MTTIEHWIGGSSTAGAGSRRAPVFNPATGQQQHEVVLADTGDVEAAVAAAKAAFTTWGQASLSARTKIMFNFRELVNANVDRLAELVSDEHGKVLSDAAGEVQRGLEVVEFACGIPQLLKGDYSDQASTGVDVFSFREPLGVCAGITPFNFPVMVPMWMYPVAIACGNTFVLKPSERDPSASNFIADLWRQAGLPDGVFNVVHGDKTAVDALLDHPDVAAVSFVGSTPIARYIHEKASATGKRVQALGGAKNHAIILPDADLEYAANHLSAAAFGSAGERCMAISAAVAVGGAGDPLMDILTRKANDVVVGSGRDPKSEMGPVVTAAARDRIESLIGTGEQQGAKVLVDGRGRRVPGFEEGFFVGPTVIDQVDTSMDVYTEEIFGPVLSVVRSESVEAAIDLINANPYGNGTAIFTNSGEAARRFQRGVHVGMIGINVPIPVPMAYYSFGGWKDSLFGDKHIHGPEGVSFYTRGKVVTSRWPHVEAAHGASMHFPTAS
>NC_022657.1|WP_023362786.1|4514044_4514944_+|TIM-barrel-protein
MAEIRHLQLGSCPDSWGVWFADDPRQTPWPRFLDELAGSGYRWLELGPYGYLPTDPAELRDELAKRDLSCAGGTVAGVGGPHKDFATVLAETRKVAELTAALGAENLIFVPVPGYRDDVTNAYHEPAELSPDGWQALIDNSNTLGRVLAEEYGLKMRFHPHADYHVETQAQTERFLAETDPRYVSLCLDTGHLAYRQADVPAIIRKFPDRIGYVHIKQMDPAIAERAVREDMAFGRAVAMGASVEPPAGLPDIPSVLEALNELDAELFVVVEQDMYPVDFDLPLPIATRTRQYLNSVGL
>NC_022657.1|WP_023362787.1|4514967_4515963_+|substrate-binding-domain-containing-protein
MTLRRTRGARLIALSAVVALGLAACSGGGKEATTDDSGGGANAAGSSGYTIAMITHETPGDTFWDKIKAGAQQAAKDEGVTLKYSNDPDASKQAVLIQNAVDSKVSGIATTLVTPDALAGSVKAATDAKIPVVGFNSGIDQYQQLGALMYFGSDETVAGTAAGKRIADAGGKHPLCVIQAAGSVALEARCAGVKSAVPGTENLQVNGADDGAVVSTLQAKLSQDKSIDYIVTLGAPIAIDALKAMEAASSKAKLITFDLNTEAAQDIQDGKIEFSIDQQPYVQGYMAVSSLYLYLKNGNDVGGGKAVLTGPSFVDKDNIATILPFTKKNTR
>NC_022657.1|WP_041841021.1|4516033_4517104_+|ABC-transporter-permease
MTQVRTTPPPPAEVPTESSNRVTLSLSNRILARPEVGALVAAVIIFIFFLSAAPAFRSAESFFTVLYQSSTIGIVAVGVGLLMIGGEFDLSAGVITITAGLVNSMLCWNYGMNLWVGALVSLAFCLFIGFVNGYLVMKTGIPSFLITLGTFFVLQGANLGVTKLVTGSVSSPDISQIDGFDSLSAIFASSFKIGPVTVWITVIWWFLFVALAAWVLQRTRTGNWIFAVGGNPDSARAVGVPLIRTKIGLFMTVSFFGWFVGMHLLYRFNTLQAGNGVGNEFLYIIAAVVGGTLLTGGYGNAIGVAIGAFIFGMTSLGIVYAGWDPNWFKAFLGVMLLLAVLVNLYVKRMSTARKVG
>NC_022657.1|WP_023362789.1|4517106_4517922_+|sugar-ABC-transporter-ATP-binding-protein
MTDTLASHADRELNKGEPLIEMTGIGKSYGAIRALRGINLRVNAGEVTCVLGDNGAGKSTLIKIMSGLHPHNEGSLKVDGEDLTFSSPRQALDHGIATVYQDLAVVSLMEVWRNFFLGSELTSGRYPLAGLKVKEMRRIADEELRKMGIVVKDINQPIGTLSGGQRQCVAIARAVYFGARVLILDEPTAALGVKQSGVVLKYTAAARDAGLGVVFITHNPHHAYLVGDHFIILKLGGTALDKTRSEVGLDELTTQMAGGDELTELSHELGR

Crispr_ID: NC_022657_9

• CRISPR_ID: NC_022657_9
• CRISPR_location: 7130765-7131352
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 13 spacers

Consensus repeat of NC_022657_9

Consensus_repeat	Method
CAAGGAAGTCGGGCCTACC	CRT

spacers of NC_022657_9

>9.1|7130784|23|NC_022657|CRT
GCAAGCCCGCGCTCGCTCAACAC
>9.2|7130826|23|NC_022657|CRT
AGAGGCCCACGTAGGACCGACAT
>9.3|7130868|22|NC_022657|CRT
CAAGCCCGCACTCACCCAACAC
>9.4|7130909|23|NC_022657|CRT
GAAGGCCCACGTAGGACCGACAT
>9.5|7130951|22|NC_022657|CRT
CAAGCCCGCACTCACCCAACAC
>9.6|7130992|23|NC_022657|CRT
GAAGGCCCACGTAGGACCGACAT
>9.7|7131034|22|NC_022657|CRT
CAAGCCCGCACTCACCCAACAC
>9.8|7131075|23|NC_022657|CRT
GAAGGCCCACGTAGGACCGACAT
>9.9|7131117|22|NC_022657|CRT
CAAGCCCGCACTCACCCAACAC
>9.10|7131158|50|NC_022657|CRT
GCCCAGCACCAGGAATGTCAGGCCTTCCACCAGCCGCACTCGCCAACATC
>9.11|7131227|23|NC_022657|CRT
GGAGGCCTGGGTGGGCCCGATAT
>9.12|7131269|23|NC_022657|CRT
GCCAGCCCGCACTCGCCCAACAT
>9.13|7131311|23|NC_022657|CRT
GCAAGCCCCGATTCACCCGACAT

CRISPR arrays and Neighbor proteins around NC_022657_9

CRISPR arrays

The CRISPR arrays of NC_022657_9

>merge|NC_022657|9|7130765-7131352|CRT
CAAGGAAGTCGGGCCTACCGCAAGCCCGCGCTCGCTCAACACCAGGGATGTCGGGCCTACCAGAGGCCCACGTAGGACCGACATCAGGGAAGTCGGGCCTACCCAAGCCCGCACTCACCCAACACCAAGGAAGTCGGGCCTACCGAAGGCCCACGTAGGACCGACATCAAGGAAGTCGGGCCTACCCAAGCCCGCACTCACCCAACACCAAGGAAGTCGGGCCTACCGAAGGCCCACGTAGGACCGACATCAAGGAAGTCGGGCCTACCCAAGCCCGCACTCACCCAACACCAAGGAAGTCGGGCCTACCGAAGGCCCACGTAGGACCGACATCAAGGAAGTCGGGCCCACCCAAGCCCGCACTCACCCAACACCAAGGAAATCGGACCTACCGCCCAGCACCAGGAATGTCAGGCCTTCCACCAGCCGCACTCGCCAACATCAAGGGAAGTCGGGCCTACTGGAGGCCTGGGTGGGCCCGATATCAAGGAAGTCGGGCCCACCGCCAGCCCGCACTCGCCCAACATCAAGGAAGTCCGGCCTACCGCAAGCCCCGATTCACCCGACATCAAGTAAGTTGGGCCTTTC

>NC_022657|9|2|7130765-7131352|CRT
CAAGGAAGTCGGGCCTACC	GCAAGCCCGCGCTCGCTCAACAC
CAGGGATGTCGGGCCTACC	AGAGGCCCACGTAGGACCGACAT
CAGGGAAGTCGGGCCTACC	CAAGCCCGCACTCACCCAACAC
CAAGGAAGTCGGGCCTACC	GAAGGCCCACGTAGGACCGACAT
CAAGGAAGTCGGGCCTACC	CAAGCCCGCACTCACCCAACAC
CAAGGAAGTCGGGCCTACC	GAAGGCCCACGTAGGACCGACAT
CAAGGAAGTCGGGCCTACC	CAAGCCCGCACTCACCCAACAC
CAAGGAAGTCGGGCCTACC	GAAGGCCCACGTAGGACCGACAT
CAAGGAAGTCGGGCCCACC	CAAGCCCGCACTCACCCAACAC
CAAGGAAATCGGACCTACC	GCCCAGCACCAGGAATGTCAGGCCTTCCACCAGCCGCACTCGCCAACATC
AAGGGAAGTCGGGCCTACT	GGAGGCCTGGGTGGGCCCGATAT
CAAGGAAGTCGGGCCCACC	GCCAGCCCGCACTCGCCCAACAT
CAAGGAAGTCCGGCCTACC	GCAAGCCCCGATTCACCCGACAT
CAAGTAAGTTGGGCCTTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023561150.1|7139989_7141090_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|238527
NC_022657.1|WP_023561140.1|7127253_7128297_-|S1-family-peptidase	unknown	unknown	gnl|CDD|365866
NC_022657.1|WP_169739483.1|7136200_7136974_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224041
NC_022657.1|WP_023561144.1|7133583_7134000_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380340
NC_022657.1|WP_023561152.1|7141616_7142678_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|234821
NC_022657.1|WP_084298477.1|7118314_7119175_-|serine-hydrolase	unknown	unknown	gnl|CDD|379138
NC_022657.1|WP_023561142.1|7131547_7132117_-|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|294013
NC_022657.1|WP_023561143.1|7132476_7133571_-|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|238527
NC_022657.1|WP_041841320.1|7128476_7129733_-|FAD/NAD(P)-binding-protein	unknown	unknown	gnl|CDD|226906
NC_022657.1|WP_023561137.1|7121717_7124789_+|discoidin-domain-containing-protein	unknown	unknown	gnl|CDD|227785
NC_022657.1|WP_023561132.1|7116960_7117737_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|225130
NC_022657.1|WP_023561145.1|7133996_7136204_-|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|239170
NC_022657.1|WP_041841322.1|7138826_7139993_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173838
NC_022657.1|WP_023561151.1|7141100_7141616_+|flavin-reductase	unknown	unknown	gnl|CDD|214900
NC_022657.1|WP_023561136.1|7120148_7121570_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_041841321.1|7136907_7137867_-|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270275
NC_022657.1|WP_023561138.1|7124814_7125798_-|hypothetical-protein	unknown	unknown	gnl|CDD|270622
NC_022657.1|WP_023561139.1|7125983_7127156_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
NC_022657.1|WP_023561133.1|7117733_7118318_+|VTT-domain-containing-protein	unknown	unknown	gnl|CDD|223659
NC_022657.1|WP_023561135.1|7119353_7120112_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023561150.1|7139989_7141090_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|238527	cd01094, Alkanesulfonate_monoxygenase, Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).	2.48049e-89
NC_022657.1|WP_023561140.1|7127253_7128297_-|S1-family-peptidase	gnl|CDD|365866	pfam00089, Trypsin, Trypsin.	9.17257e-09
NC_022657.1|WP_169739483.1|7136200_7136974_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	1.31977e-91
NC_022657.1|WP_023561144.1|7133583_7134000_-|cupin-domain-containing-protein	gnl|CDD|380340	cd02210, cupin_BLR2406-like, Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to BLR2406, a Bradyrhizobium japonicum protein of unknown function with a cupin beta barrel domain. Proteins in this subfamily appear to align closest to RmlC carbohydrate epimerase which is involved in dTDP-L-rhamnose production, and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.69428e-36
NC_022657.1|WP_084298477.1|7118314_7119175_-|serine-hydrolase	gnl|CDD|379138	pfam13354, Beta-lactamase2, Beta-lactamase enzyme family. This family is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.72177e-10
NC_022657.1|WP_023561142.1|7131547_7132117_-|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|294013	cd00383, trans_reg_C, DNA-binding effector domain of two-component system response regulators. Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.	8.82358e-33
NC_022657.1|WP_023561152.1|7141616_7142678_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|234821	PRK00719, PRK00719, alkanesulfonate monooxygenase; Provisional.	1.77974e-156
NC_022657.1|WP_041841320.1|7128476_7129733_-|FAD/NAD(P)-binding-protein	gnl|CDD|226906	COG4529, COG4529, Uncharacterized protein conserved in bacteria [Function unknown].	9.29174e-83
NC_022657.1|WP_023561137.1|7121717_7124789_+|discoidin-domain-containing-protein	gnl|CDD|227785	COG5498, ACF2, Predicted glycosyl hydrolase [Cell envelope biogenesis, outer membrane].	8.07344e-79
NC_022657.1|WP_023561132.1|7116960_7117737_+|MBL-fold-metallo-hydrolase	gnl|CDD|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	8.55594e-33
NC_022657.1|WP_023561145.1|7133996_7136204_-|molybdopterin-dependent-oxidoreductase	gnl|CDD|239170	cd02769, MopB_DMSOR-BSOR-TMAOR, The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its cellular location and oligomerization state are organism-dependent. For example, in Rhodobacter sphaeriodes and Rhodobacter capsulatus, it is an 82-kDa monomeric soluble protein found in the periplasmic space; in E. coli, it is membrane-bound and exists as a heterotrimer. BSOR catalyzes the reduction of biotin sulfixode to biotin, and is unique among Mo enzymes because no additional auxiliary proteins or cofactors are required. TMAOR is similar to DMSOR, but its only natural substrate is TMAO. Members of this CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NC_022657.1|WP_041841322.1|7138826_7139993_+|acyl-CoA-dehydrogenase	gnl|CDD|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	3.90986e-49
NC_022657.1|WP_023561151.1|7141100_7141616_+|flavin-reductase	gnl|CDD|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	1.36821e-43
NC_022657.1|WP_041841321.1|7136907_7137867_-|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	gnl|CDD|270275	cd13557, PBP2_SsuA, Substrate binding domain of sulfonate binding protein, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes the sulfonate binding domains SsuA found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.91172e-54
NC_022657.1|WP_023561138.1|7124814_7125798_-|hypothetical-protein	gnl|CDD|270622	cd00180, PKc, Catalytic domain of Protein Kinases. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.	2.07786e-06
NC_022657.1|WP_023561139.1|7125983_7127156_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.07628e-51
NC_022657.1|WP_023561133.1|7117733_7118318_+|VTT-domain-containing-protein	gnl|CDD|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	3.60311e-16
NC_022657.1|WP_023561143.1|7132476_7133571_-|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|238527	cd01094, Alkanesulfonate_monoxygenase, Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).	1.11472e-91

Protein sequences

>NC_022657.1|WP_041841320.1|7128476_7129733_-|FAD/NAD(P)-binding-protein
MARAVVVVGGGCSGVLVARELLRCSDDDVVLVEPGVPGGGVAYGTAQPWHLLNSRAGAMSADPDDPDHFVRWAGTTPAAFRPREEYGRYLRDVLDEAAREHPGRLQLRRARAAAITPDGTVALDDGSAVTADHVVLATGGPASARQAIVHPHYVNDPWRPGVLEALPADRPVLLIGTGLTAVDVALTLAADGTRTAPIVAVSRRGLLPLTHTTTAAPPAVPSLDDCATLRDVVRAVRHAAGEAGDWRAIVDGLRPYLDELWTALTPGEQDAFLRHLARPWECHRHRMAPPVAARVAELRADGRLEIRAGGVAAWPGLADYAAVINCAGPGRLPGAAGPLVGGLLAAGLARVGPHGLGLDIDPAGRLIGAGGQVQERLWLIGPLRRGARWETTAVPEIRAQARRLVTDLSAGVPVAAAA
>NC_022657.1|WP_023561140.1|7127253_7128297_-|S1-family-peptidase
MRNPGSKLGRPIVGLAAVLLVGSAFASPASAAPSVASDPSFAPSALATKLDSQFGTAAAGSYVDSAGKLVVNVTDAATAKSVTASGATPRYVTHSGAALAAADSTLKATLKTPGTSFGLDPVSNKIVVTADETVTGAKLSAVKAIVAKLGDKATFESVSGTLRTTISGGDAIYAGGGRCSLGFNVRNSAGTNYFLTAGHCTNIASTWTNGSTTLGTRSGTSFPGNDYGIVRYTNTTITKSGAVGSQDITSAGTPAVGATVYRRGSTTGLRSGRVTALNSTVNYAEGSVSGLIRTSVCAEPGDSGGSLYAGTTALGLTSGGSGNCSSGGTTYFQPVTEALNVYGVSVF
>NC_022657.1|WP_023561139.1|7125983_7127156_-|cytochrome-P450
MPPAETPLESQRKIARGDLSPGCPVHAGPDGVWHVQDFSTARAMLRSTETRQAGFGVEHAVKLEGRMRMPVLYRDGPEHREHRRQTAKYFTPKRVETAYRALMNRLADEQCAVLKAKGTADLSQLSFRLAVAVAAEVIGLTESGPGMARRLDRFFEEKDGTRLVRKWKDLRSNANMGLFYWRDVRPAIAARRAAPKDDLISHLLTEGCNNGEILGECVTFAAAGMVTTREFITLSAWHLFTDDNLRRSYTTGDDKERVAILHEILRLEPVVANLARWTTAEIEAGDVTIPAGARLDIGVAAANMDPDAVGADPGAVCPARPKADGVGDAGLSFGDGPHRCPGAYIAIQETDIFLTKLFSLPGLRMVDPPKVGIRAEIASYEITNLKITVN
>NC_022657.1|WP_023561138.1|7124814_7125798_-|hypothetical-protein
MRVERHREAGRLLGELADDALAELVDGAVVLRSGIGGRTALLDLDGIKVFVKRIPLTDLERQPRHVGSTANLFGLPTFYQYGVGSTGFGAWRELATHVKTTGWVVDGVSEHFPLLHHWRVLPATPVAMPDFGDWDGDPAVRRRVAAISEATSSIVLFLEYLPWSLHEWLLIRFDAGDGERAVTLADRQLHAGTELLRERGIVHFDAHPGNVLTDGEQLYFSDFGLALDQEFERTPAEAAFQELHRDWDRYDVERYLVNWLCERLAPDVDRTEVIRSGGAGLPEFAAAVVRRYGPAVLVLNDFYGRLVAGPKTTPFPLEELKSPPRHG
>NC_022657.1|WP_023561137.1|7121717_7124789_+|discoidin-domain-containing-protein
MKSPLPPSRSPGTHRRPRRGRLAGFAAAVVVALGSGALAVAVVGNAEAATIGAGSYTETLPAGAKLPSGCGNISTNPRQYLTPNAPAGPVPTNDWWSSLLFKKGDECNFSQPLFAGPAAYKPVAGGLGISYQTDAAISGSATGLGEYHYPYAQHVVAGVAGLNAGQALVDGWSDWTVTPSWSDGSRTLKATIGHGLPLSYYQVTGGDALLTITGPPTAWQNTGNRIGFSIGGHDYVAYGPAGSTWTLSGSTIRSNLAGKGYFSVAVLPTLASAATADKIALADQYGQYAHNHVTGTKMSYTYNQGAGTVNTTYAFTTTAREGSASGTVIALYPHQWRYLTGSTPLSRTYVSPRGAMKIVLGTNFTTSMKYTGVLPEIPAVGDSSGADLSTITTYLNNELNNPADFKGDDTYWTGKGLGRAARIAEIADQLNLTSVRDNALNVIRTRLTDWFTASAGKSSRVFYYDRNWGTLIGYPASYASDEDLNDHHFHYGYYVAAAATLAKFDPAWAAPGQYGGMVDLLIRDANNYDRNDTRFPYLRDFDIYAGHDWASGHGAFGAGNNQESSSEGQNFANALIQWGQATGNTTVRDAGIWLHTTQAAAINEYWFDVRNENFPANWGHNYSAIVWGSGGAYATWFSGEHAMIVGINMLPMTGGQLYLGDYPASVRSTYAELVRNNGGEPTVWRDMLWQYLALGDPDAALAKFRANSSYTSEEGESKAHTFHWIRNLAALGQVDTGVTANHPLAKVFSKNGAKTYVASNITNAALTVTYSDGKTLSVPAGKTVANGATNWSGGNATGGGTTTPPTTPPTTPPTTPPCNGALLSQGKTATSSSVEAGYPADLAVDGNATTRWSSAFADPQWLQVDLGSAQPLGRVELSWEAAFGKAYQIQTSTNGTTWANAVTVTAGTGGNTSHALSGTARYVRMNGTERGTPYGYSLFKFKVFGSTCGTTPPPPVTTPPTTTPPATTPPATTPPSATAWAINTAYTAGRVVTYNGVSYRCLQAHTSLTGWEPPNVPALWARN
>NC_022657.1|WP_023561136.1|7120148_7121570_+|hypothetical-protein
MARNSNSGWSRPWAAFFALVIVLGGVAVSLGFGVRLRGALERSAEKRIATTSQSLQGSVTNELGRYSDSVRLAAAALSAQSTPTRGGFDKITTAVAAQDLTAVRSITFVVRATPTTVGEVRPYWRARGAEGLDPQPVEGLQEHLFTVFSRGLGDFERPPIGVDQGAAQAEVDVTKLARTGKDVAISDAYVRLADTKLPKAQQRLSFDVVAPVFGDKQAVAGYLVLNVGGNEFVSTTLFRAAGDLLDAQLLTRSGGGSLAEVAAVVQQSVTRSTFRRTQNFEAGQRQWTLRTSAAYTTLLPNAGRTDMAVVIAGSVLAVMFGSLMYLQMSAAKRTEEEISLEVAERVEAYEKGSDRTRLEELVGGLLEAGQVSEVDLRVVVDDAVATVLPEDTTPEITIGELAAVRADVVLLRHLVGTMVTDAVRRTPDGEEPRISIGLDPEVGPERVRLVIESAGTAVGCTLPAVEQMAANPS
>NC_022657.1|WP_023561135.1|7119353_7120112_+|hypothetical-protein
MALLPSPGAFVELSRYAIGQVVETAASVATVPVRVLGLLGQTELLVSRISLLAERAEGLIGRVEGVIDGVDTTLRETKVIMAAAALTVDEASAVALRAAQVVDGAASAVTGASAIVTEAGTVVTKAGKTADDAGGVVVQAKATADEAGALLDGYAPTLRSAAPLAQRFVEELTPEEVTAAIRMVDELPRLRQHLSEDVMPLLGKLDQVGPDLHKLLEVTNDLHLAIIGLPGLKRLRRRGEERAAEEEAANDR
>NC_022657.1|WP_084298477.1|7118314_7119175_-|serine-hydrolase
MQDGGSAGGGGGVLPRSLTFGDDSSPTPKASPTPTGPSPEELAARERAKRVKALDAALKKYAKSSPEFSVAVLDKKTGERYSYRGSEKYDTASIVKVQVLACMLLQAQDDDRDLSSSQLALAKRMIRLSDNNATTSLFVQLGKVSAVSKCNKRLGLKQTVVSSSWGLTRTTVDDQVRLLSELVDTKGPLDKDSRKLAFTLMNTVDDTQDWGVPSVAKSGETTTVKNGWDTRSADGGLWAVNTVGRITADDDVDISVAVLSHNNQSMDGGITLVQKVAKMTRQYLKY
>NC_022657.1|WP_023561133.1|7117733_7118318_+|VTT-domain-containing-protein
MISELGTMGWLALVVAFGAIVPIIPTGAAVSGAAALAFHDHPLLIVLVIAAGAAGAYVGDLVMYAMCRAGGEQLARRLRWLRDEEHLAAVKERLHKSQIPVLLVSRLLPGGRVPVLLAAAFLGLSWRTFVVANAPACALWSVVYAGIGVAGGSIFPEPWEGVVAAIILVLIIGQIVNLISKRRAARQQAEAEAA
>NC_022657.1|WP_023561132.1|7116960_7117737_+|MBL-fold-metallo-hydrolase
MSGTSVTWWGHSTMWLADSGVSLLTDPLLTDRLIHLRRMAGPTPVLDGAPDAVLLSHLHADHFHLPSLRAIPGEPLLIVPRGSVPLVAKGLGSAYARRCVELAPGEETTVGAIKVRAVEAAHDGGRGPWSRLRSAAMGFVVEGEARTWYGGDTGLFDGMSSLGPLDLALVPVGGWGPTLAAHGHLDPADGAEALRRVKAAWAVPVHYGTFWPAGLGRVRPHMFHDPGTEFARHAARTSPDTHVRVLAHGETLSFEPAT
>NC_022657.1|WP_023561142.1|7131547_7132117_-|winged-helix-turn-helix-transcriptional-regulator
MSVLADLLEARPVTARPVPLRRGPGRPRGTRLRSITTPTTSVTVTITLGDPGSEEGARVLAALRDLVVAAGPDANIDLTPLDPRPSPGPGVAGLRLDPRPRTATFDGRPLDLSRLEYELLLFLAQHPRQVFSRSQLLGHVWGHTHTTVRTVDVHVSRLRTKLGNPDIVTTVYGVGYRLADDTSITVADA
>NC_022657.1|WP_023561143.1|7132476_7133571_-|LLM-class-flavin-dependent-oxidoreductase
MPVDFIGLIATQDGSESTPATGPLVNRDYTARIARAHEDSGFDQVLIGYSSAYPDGAQVAAYAAAHTSSLKFLVAHRPGFVAPTLAARTFASLDHFTGGRTTLNIITGGHDTEQRRDGDYLSKDDRYARTDEYLTILRRAWTSTAPFSHEGRFYKFDDFVSQVRPVDGTIPLYFSGSSPAAYRTGVKHADVYMFWGEPLAQTAEQIASVRAAAAAAGRPVPRFSVSFRPILGATDDLAWERAHAILGRIGSVTAPRFFRNRDKDNPANVGSQRLLAAAATQDRHDRALWTATAKASGAAGNSTALVGTPETVAQALLDYHELGVTTFLIRGYDPLDDTIDYGRELIPTVRTEIARRDAADLVTA
>NC_022657.1|WP_023561144.1|7133583_7134000_-|cupin-domain-containing-protein
MTDEFHQKLHHIAPLGLSGDTAQTKGMTRIEAISGKTVGSKDLWMGETHVSAATASDNHHHGESETAIYIVRGNPVFVFYDAEKDEETRLETKPGDYIFVPPWVPHREENPDPDNEAVVVIARTTQEAIVVNLPSLKS
>NC_022657.1|WP_023561145.1|7133996_7136204_-|molybdopterin-dependent-oxidoreductase
MTTTSSSHWGAFRVSGTGTALQVTPRPGDPDPSPLLGNLAGAHRHRSRVARPALRRPRAGRGYDSFEEVSWDTALDHVAAELSRVREQHGDSAIFGGSYGWASAGRFHHAQSQLHRFLALGGGYTASRNSYSLGASLVALPHLVGRRGAHAVIREGTDWPVIAGHTDLIVAFGGIRTANTYVTPGGRAVHDFRGHLRAATARGLRVASVSPLRDDLSPELAGDWLAIRPGTDVAVMFALAHQLAADGHADLAFLDRFTVGGDRFLADVKDRTPAWAAGVSGLSEQSIVDLARRMAAGRTLVTVSWSLQRTPYGEQPLWAGLALAAVLGQIGLPGGGFGHGYGSMGDVGGGALPYGLPTFPQVRNPVADFIPCARVADLLLHPGTEFDYDGERYTYPDTRLVYWAGGNPFHHHQDLSRLRRAFARPETVIVHEPYWTATARHADVVLPVTTTLERDDLGAGRGDTHLIAMQRADEPYAQARDEYDIFAGLAARLGYHDAFTEGRTSGEWVRHLYEGWRVDRGLPGFDDFWSAGEVVLPGRRENTVLFEDFRAGRPLDTPSGRIELSSATVAGFGYEECPGHPVFHEPALSAYPLVLICNQPGTRLHSQQDMGGVSRASKVHDREPLRLHPADAAARGITDGDVARVFNNLGSLLAGVRLTDACAPGVAQLSTGAWFDPSAPDVATCVHGNPNVLTEDLGTSRLAQGCTGQHARVEITRHDGPLPAIRAFDPPLENQ
>NC_022657.1|WP_169739483.1|7136200_7136974_-|ABC-transporter-ATP-binding-protein
MAQRPQGPQRQDQYRRPRGEAVTTAVEAPAVRARTITRRYADRTVLHELDLEIRRGEFVALIGKSGCGKTTLLRTLAGLDRLDGGDLTVPSSSTVVFQEHRLLPWEKVWRNVALNLPRATARSRAQSALEEVGLGDHADVWPVTLSGGEAQRVALARALVREPELLLLDEPFAALDALTRIRMHGLVRDLIARHRPAVLLVTHDVDEAILLADRVLTMRDGRIAADHPVTGPARHRGDPAFVSLRAELLSELGVVEQ
>NC_022657.1|WP_041841321.1|7136907_7137867_-|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein
MTLSRRSLLGAALALPVLAACGDTAAEANGRKKVRLTYGPISVPKTRGVFEKTLNDQGIDVEWVGPFPNHAPTLQAVATDTADFSFGGSSTPADQALLSGNRLKYVAWATATPRLSSILVLPDSGINSVKDLAGKNVAVNKAGLGEFLLVAALEKYGVPRDSVTFTYLNPPDAAPAFGSGKVDAWGIWSGPMELAEVQYGAKRLFTDGDELDKQIDFSTYLVREDYAKKEADTIRKVIAAYKAEADWVNTNQAEAQKIGNEVSKYPQAVVDKLVAQNVQTTWSLITDDGIAQLQAGADWLSDRKVLSGKINIADHAVKL
>NC_022657.1|WP_041841322.1|7138826_7139993_+|acyl-CoA-dehydrogenase
MPTPAADAPALPKPQLSQLVDVTAALAEHAEEHDRTADLPEKGLAIVHTAGLLTLTVGTRHGGPGGGLHDTVRTLTALGQGDPSVALISAMTLFAHAAAASWPADVYAEVLAESARRPTLINALRVEPDLGTPARGGLPATTARRTTDGWELTGHKIFSTGATGLRWMQVWARTDEDPVRTGAFLVRTDSPGITVERTWDHLGLRASRSDDVTFDRVKVPAGATLDLAAPGPPGADPGGLRAWNALGIAAIYLGVARAARDWLVGYLQDRVPTNLGKPLASLPRFQNEVGVIAAQLLAATSLVETTALAVDRGAVLDPAQPNIAKSVATNAAIDSVQRAVALIGNAGLTRHNPLERHLRDVLCGRIHTPQDDVVLASAGRTLLERNPR
>NC_022657.1|WP_023561150.1|7139989_7141090_+|LLM-class-flavin-dependent-oxidoreductase
MTVEFVGMIGTRDVSETRAPSGPPIDLEYVRRFSRVHEEAGFDRVLIGYGSSTPDGTQVAAYAAAHTSQLGLLIAHRPGFVAPTTAARTFATLDQLSGGRVAVHTITGGSDAEQRRDGDYLGKDDRYARTEEYLSVLRRAWTSPEPFSHDGRFYKFEDFSLLAQPAHRIPLYFGGSSEAAYRAGGAVADVYALWGEPLKETAEQIAKVQASAAAAGRDPLGISVSFRPILAATDALAWERAERILATIEESKGGKGSFTGDKTRVLGGPSPENVGSQRLLAAAARSDRHDRALWTATAKASGAQGNSTALVGSPETVAQALLDYVDIGVTTILIRGYDPVDDAVDYGRHLLPLVKQELSHRSLVAA
>NC_022657.1|WP_023561151.1|7141100_7141616_+|flavin-reductase
MTVTPLHQDRAVDADLFRALLRRHAAAVVVITAPGEPPAGFTATSFTSVSLDPPLVSFCLAKSASAWPAVQAASTIAVHVLTQEQEHVARTFATRGIDRFAAHGAWRPGPDGVPLLEGVLATIVCKVAQHVEAGDHTIVLATPELGEHHADTTVTPLVYHDGTYAHLQRSA
>NC_022657.1|WP_023561152.1|7141616_7142678_+|LLM-class-flavin-dependent-oxidoreductase
MQIHWFLPTAGDSHGITSGGQAAATVVTERPPDLGYLAILARAAERLGFTGMLTPTGTFCEDAWITTAALLAETSTLKFLVAFRPGLVSPTLAAQMASTYQRISGGRLLLNVVTGGESTEQRRFGDWLDHDQRYARTAEFLQVLRGAWSGEPFDFTGEHYRIEGATTRLTPDPVPPIFFGGSSPPALRVAAAHADTYLTWGEPPDAVSAKLAAVRALTDRPLTYGIRLHVITRDTAAEAWAAARALLDRVPPQAVEAARERFARTESEGQRRMAELTGGDSLEVSPNLWAGFGLVRPGAGTALVGSHAEVADRIAEYHALGIDHFILSGQPHLEEAYRFGEGVLPLLKLGAAA

Crispr_ID: NC_022657_10

• CRISPR_ID: NC_022657_10
• CRISPR_location: 7287298-7287502
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: csa3

Consensus repeat of NC_022657_10

Consensus_repeat	Method
CCCGCACCCGGTTAGTGAGCGTTTACCAACTC	PILER-CR
CTGGTCGGAGCAGAACACGAGCACCACCACGACCACAACCACCCGCACGAACACC	CRISPRCasFinder

spacers of NC_022657_10

>10.1|7287330|58|NC_022657|PILER-CR
TGGTCGGAGCAGAACACGAGCACCACCACGACCACAACCACCCGCACGAACACCGACT
>10.2|7287420|58|NC_022657|PILER-CR
TGGTCGGAGCAGAACACGAGCACCACCACGACCACGACCACCCGCACGAACACCAGCT
>10.3|7287377|35|NC_022657|CRISPRCasFinder
GACTCCCGCACCCGGTTAGTGAGCGTTTACCAACG

CRISPR arrays and Neighbor proteins around NC_022657_10

CRISPR arrays

The CRISPR arrays of NC_022657_10

>merge|NC_022657|10|7287298-7287502|PILER-CR,CRISPRCasFinder
CCGGTTAGTGAGCGTTTACCAACTCTGGTCGGAGCAGAACACGAGCACCACCACGACCACAACCACCCGCACGAACACCGACTCCCGCACCCGGTTAGTGAGCGTTTACCAACGCTGGTCGGAGCAGAACACGAGCACCACCACGACCACGACCACCCGCACGAACACCAGCTCCCGCACCCGGTTAGTGAGCGTTTACCAACTC

>NC_022657|10|1|7287298-7287502|PILER-CR
CCGGTTAGTGAGCGTTTACCAACTCTGGTCGG	AGCAGAACACGAGCACCACCACGACCACAACCACCCGCACGAACACCGACTCCCGCAC
CCGGTTAGTGAGCGTTTACCAACGCTGGTCGG	AGCAGAACACGAGCACCACCACGACCACGACCACCCGCACGAACACCAGCTCCCGCAC
CCGGTTAGTGAGCGTTTACCAACTC

>NC_022657|10|8|7287322-7287466|CRISPRCasFinder
CTGGTCGGAGCAGAACACGAGCACCACCACGACCACAACCACCCGCACGAACACC	GACTCCCGCACCCGGTTAGTGAGCGTTTACCAACG
CTGGTCGGAGCAGAACACGAGCACCACCACGACCACGACCACCCGCACGAACACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023561277.1|7282479_7283232_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_022657.1|WP_023561275.1|7281746_7282070_+|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
NC_022657.1|WP_158510588.1|7284826_7286125_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NC_022657.1|WP_041841343.1|7300949_7302311_+|alkaline-phosphatase	unknown	unknown	gnl|CDD|236706
NC_022657.1|WP_041841341.1|7277157_7277718_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379883
NC_022657.1|WP_023561274.1|7281125_7281650_-|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NC_022657.1|WP_148308141.1|7282129_7282471_+|SRPBCC-domain-containing-protein	unknown	unknown	gnl|CDD|176903
NC_022657.1|WP_041841342.1|7293897_7295856_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NC_022657.1|WP_023561287.1|7300521_7300848_+|TfoX/Sxy-family-protein	unknown	unknown	gnl|CDD|377438
NC_022657.1|WP_023561285.1|7295912_7298798_-|hypothetical-protein	unknown	unknown	gnl|CDD|197594
NC_022657.1|WP_023561282.1|7291567_7292161_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NC_022657.1|WP_023561278.1|7283251_7284649_-|DUF4331-domain-containing-protein	unknown	unknown	gnl|CDD|379511
NC_022657.1|WP_023561286.1|7299264_7300479_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561281.1|7288368_7291479_+|signal-transduction-protein-with-Nacht-domain	unknown	unknown	gnl|CDD|227922
NC_022657.1|WP_084298225.1|7302351_7303875_-|sugar-transferase	unknown	unknown	gnl|CDD|274398
NC_022657.1|WP_084298224.1|7292164_7293901_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NC_022657.1|WP_023561271.1|7277718_7278225_-|DinB-family-protein	unknown	unknown	gnl|CDD|368218
NC_022657.1|WP_023561272.1|7278232_7280446_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|376899
NC_022657.1|WP_023561273.1|7280442_7281129_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222
NC_022657.1|WP_023561290.1|7304369_7304591_-|ferredoxin	unknown	unknown	gnl|CDD|379198

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_022657.1|WP_023561275.1|7281746_7282070_+|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	9.3e-14	46.6	0.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023561277.1|7282479_7283232_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.48729e-09
NC_022657.1|WP_023561275.1|7281746_7282070_+|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.75152e-13
NC_022657.1|WP_158510588.1|7284826_7286125_+|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	5.36274e-09
NC_022657.1|WP_041841343.1|7300949_7302311_+|alkaline-phosphatase	gnl|CDD|236706	PRK10518, PRK10518, alkaline phosphatase; Provisional.	0
NC_022657.1|WP_041841341.1|7277157_7277718_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	7.71919e-23
NC_022657.1|WP_023561274.1|7281125_7281650_-|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.08872e-13
NC_022657.1|WP_148308141.1|7282129_7282471_+|SRPBCC-domain-containing-protein	gnl|CDD|176903	cd08894, SRPBCC_CalC_Aha1-like_1, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	2.488e-13
NC_022657.1|WP_041841342.1|7293897_7295856_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NC_022657.1|WP_023561287.1|7300521_7300848_+|TfoX/Sxy-family-protein	gnl|CDD|377438	pfam04993, TfoX_N, TfoX N-terminal domain. TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes. This family corresponds to the N-terminal presumed domain of TfoX. The domain is found as an isolated domain in some proteins suggesting this is an autonomous domain.	2.25538e-10
NC_022657.1|WP_023561285.1|7295912_7298798_-|hypothetical-protein	gnl|CDD|197594	smart00237, Calx_beta, Domains in Na-Ca exchangers and integrin-beta4. Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins).	2.70209e-11
NC_022657.1|WP_023561282.1|7291567_7292161_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.36066e-07
NC_022657.1|WP_023561278.1|7283251_7284649_-|DUF4331-domain-containing-protein	gnl|CDD|379511	pfam14224, DUF4331, Domain of unknown function (DUF4331). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 223 and 526 amino acids in length. There is a conserved FPY sequence motif.	0
NC_022657.1|WP_023561281.1|7288368_7291479_+|signal-transduction-protein-with-Nacht-domain	gnl|CDD|227922	COG5635, COG5635, Predicted NTPase (NACHT family) [Signal transduction mechanisms].	1.88762e-08
NC_022657.1|WP_084298225.1|7302351_7303875_-|sugar-transferase	gnl|CDD|274398	TIGR03025, EPS_sugtrans, exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase. Members of this family are generally found near other genes involved in the biosynthesis of a variety of exopolysaccharides. These proteins consist of two fused domains, an N-terminal hydrophobic domain of generally low conservation and a highly conserved C-terminal sugar transferase domain (pfam02397). Characterized and partially characterized members of this subfamily include Salmonella WbaP (originally RfbP), E. coli WcaJ, Methylobacillus EpsB, Xanthomonas GumD, Vibrio CpsA, Erwinia AmsG, Group B Streptococcus CpsE (originally CpsD), and Streptococcus suis Cps2E. Each of these is believed to act in transferring the sugar from, for instance, UDP-glucose or UDP-galactose, to a lipid carrier such as undecaprenyl phosphate as the first (priming) step in the synthesis of an oligosaccharide "block". This function is encoded in the C-terminal domain. The liposaccharide is believed to be subsequently transferred through a "flippase" function from the cytoplasmic to the periplasmic face of the inner membrane by the N-terminal domain. Certain closely related transferase enzymes, such as Sinorhizobium ExoY and Lactococcus EpsD, lack the N-terminal domain and are not found by this model.	4.98775e-143
NC_022657.1|WP_084298224.1|7292164_7293901_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.00922e-162
NC_022657.1|WP_023561271.1|7277718_7278225_-|DinB-family-protein	gnl|CDD|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	1.1623e-42
NC_022657.1|WP_023561272.1|7278232_7280446_-|ABC-transporter-permease	gnl|CDD|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	0.000342531
NC_022657.1|WP_023561273.1|7280442_7281129_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.28818e-95
NC_022657.1|WP_023561290.1|7304369_7304591_-|ferredoxin	gnl|CDD|379198	pfam13459, Fer4_15, 4Fe-4S single cluster domain.	1.82596e-11

Protein sequences

>NC_022657.1|WP_158510588.1|7284826_7286125_+|tetratricopeptide-repeat-protein
MRKRWTRPALVITLAAATLVGAGVALGPLRKPPAETAAPVSPTRDLDAYVTRTSVHLADVPGDWQAWAQLGLAHVQLARITYDPGHYPAAEKALRRSLTVRPQRNAAALTGLGALAAARHNFREAAGFAERAVAADHYSADAYGVLTDAYVELGRYPEATRAVQRMLDLRPDTGSFGRASYLFELRGNLPKANELMRRALDVAVDPADITFALTHLAELAFNAGDLGTATGYLTEGLSRRPGEPALLADRAKVSAARGDLDAALTDLRAATATLPTVDHLVTLADTLEAAGRSRTATDDLVRVSTRLPGAGPSTTDIDLVLFHADRGEGAAAVAQGRALLAARPSVTVETAYAWALHSAGRDREARKHADRGLRLGTRDARAHYYRAMIRLELGDRAGARTDLTQALRINPHFSLRYAPKARAQLADLDGPA
>NC_022657.1|WP_023561278.1|7283251_7284649_-|DUF4331-domain-containing-protein
MRFTEFKRRRGLVIVTAAGVTAACVASLAPVQSIASSHREAPLIASTPSLDNTDLYAFVSPDDANTVTMVASWQPFEEPNGGPNFYPFAEKTAHDINIDNNGDAKPDITYRWMFTTSYQNPNTFLYNTGVVSSLQDKDLNVRQTYKLERITPSGTKTILSSARVAPSFTGKASMPNYESLSNAAVTSAGAGAKSFAGQSDDAFFADLRVFDLLYGGDLTEVGQDTLKGYNVNTIALKVPKSELALKGDATRNPVVGIWSTTSRMGASMHGKPATMNQVSRLGMPLVNEVVIPLGKKNEFNATKADSDAKFLSYVQKPEVPKLIKAIYNIPAPAEPRNDLVEVFLTGVCKACGPVAADLNSQKLNKDVNPKAFAPSEQLRLNMAVPTTATPNRLGVVGGDLAGFPNGRRLSDDVIDITLQAAEGILLPNPPAAVATLGDGVNTNDHAFRSSFPYVSLSNMTTVSKS
>NC_022657.1|WP_023561277.1|7282479_7283232_+|alpha/beta-hydrolase
MPEVISQDGTTIVYDRSGAGPALILIDGAMCHRSAGPMQALATLLTDHFTVYTYDRRGRGESGDTAPYAPEREAEDVQALIAEAGGTAYLYAMSSGGAVALRTPGAAGVVLYEPPFGLGSREYTDRLRELLAAGSNGDAVALFMRNVGVPEPVVTGMRNQPGFASVEAIAPTLAYDDELLTEMPADQGVPLLVVSGSASPESLQKAARMTAEAFPGADHRTLEGQTHDVQPAALAPVLIDFLRNAGAGPR
>NC_022657.1|WP_148308141.1|7282129_7282471_+|SRPBCC-domain-containing-protein
MTQPEHLTHFWGPDGTTTPLENIVVDLRPGGVFETTMVNDADGSAYTMRAVYEVVHRPERLVWLDRGIRTTVTFVDLRDGRTEVVTHQTEAPQASAGFLSSLDRYAGYVAGLT
>NC_022657.1|WP_023561275.1|7281746_7282070_+|winged-helix-turn-helix-transcriptional-regulator
MDELSLVFGALADPTRRTIVERLARGNATVTELAELFAISQQAVSKHLKVLEHAQLISRTRSAQSRPCVLEAERLDAAVGWVAENKQVWADRHDRLEQHLARLRGER
>NC_022657.1|WP_023561274.1|7281125_7281650_-|PadR-family-transcriptional-regulator
MTVPLTLLGLLEREPSHGYDLKRDYDAFFGRGKPLSFGQVYATLSRLARDGKVVISDVEPGEGPDRKRYIITDVGATEVDTWLKEPVAAEPHLQTVLFAKVTLALMLGRNAEAYLDTQRAAHLQRMRELTEIKRNGSLVDALLADHGLFHLEADLRWIELTSVRLESLAKAVRG
>NC_022657.1|WP_023561273.1|7280442_7281129_-|ABC-transporter-ATP-binding-protein
MTEMLLEARDVVLSFGRTQALRGAELRVAAGEILAIMGPSGSGKSTLLHCLAGILVPESGEIHFDGRRIDNLGETGRSALRRDRFGFVFQFGQLVPELSAEENVALPLLLNGVRRTKALAEARPWFDRLGLDGLEERRSGELSGGQAQRVALARGLVARPRVLFADEPTGALDTLTGEQVMDLMVSSAREQGTTVVLVTHEPRVAAYADREVIVRDGRVHALTAEAVA
>NC_022657.1|WP_023561272.1|7278232_7280446_-|ABC-transporter-permease
MIRFGLRLTLAGGREALVRLVVIAVAVALGVGMLLTALAGAGGVTTQNDRYGWANSAFAPGAEDGPDPLWWQTRIDGFDRRTVGRVDLAATGAASPVPPGLPRLPAAGEYFASPELAQLLATTPAAQLGDRFPGRLAGTIGPEALPAPDSLVAVVGYAPEVLSQRPGVSRVGKIQTVAPTSCPQGCWSGIPAAGLQLILAVVAAALIFPLLILIGSATRLAATRREQRFAAMRLVGATPRQVSVVSAVESTVSAFAGTALGFALFFLFRDTLAAIPFTGSPMFPSDLALGPVTVIGVALGVPVAAALVARFALRQVQISPLGVTRRVTPKPPRVWRVIPLLLGLGELAYFIGRRPDTTSGQLLAFLPGILVIMLGLIIAGPWLTMAGARLVARRASRPASLIAARRLADNPRAGFRTVSGLVLALFVTTVAVGVMGSIAAEQNVSREDPSAAGLFTLFRDEDRAPTGDPVPAALTSLPGVRGVAVTRVPPESVPVPHVEIGELGWPYALVSCADVARIPDARQCAPGAEVAWTWPGLDGPPGWQGTWPRADVDAAALTGFKVMAILTVTDGSTPALEEARTVLQNAHPMLYSPYSGVEFQADSARVFNGWKQLANVVILTSLAIAGCSLAVSIAGGLSDRRRPFSLLRLTGVSLGTLRRVVALESVTPLLVAAVVALGSGLLAAQLFLTAQMDSTLSPPSVSFYVIVVAGLATSLAVIASTMPLLRRITGPEAARNE
>NC_022657.1|WP_023561271.1|7277718_7278225_-|DinB-family-protein
MTDDRIGPPLLGGERETVRAFLDYHRATLEMKCAGLSDDELRQRSMPPSTLTLMGLLRHLAEVERTWFRRVINAEDIPLIWSDSGDFQAAYDPAGSTGAEAFTVWREEVEHSRRIEREAESLDVTGYQARWEEKVSLRLVMLHMIHEYARHNGHADFLREGVDGTVGA
>NC_022657.1|WP_041841341.1|7277157_7277718_+|TetR/AcrR-family-transcriptional-regulator
MPDQARRSERSRVAILTAARELLAEAGYAELTIEAIAARAGVGKQTIYRWWRGKGAIILDALMETGDNVEPLPDSGDLRADLVAVVRATVAELADPRLSATTRALTIETLSNDELAEQVRDRVLRPQMEAIKDRLRTGPLRPEINLDQAVELLIGPPYHRWMLRTGPLTDEYADGVVDLALAAFQK
>NC_022657.1|WP_023561281.1|7288368_7291479_+|signal-transduction-protein-with-Nacht-domain
MSGSPYTLETAREILAGQRSPVVKALDKLLGYGILAAGPLGLATGHPWLLAAWQWVDQKNELMVHLDGLVATGRKKLGKATGRRRHELLAATHTALVTAAFFEALQAIAGPATGDLSDDDRRRLVGEPGTDQLFHDAVEQLLAVEIDLPWAGSGFDATVHSSIRPYYMTLAHRTLSWMSNFAAWTERFGTGTGPRPLHAQIVEHAVERYRAEYLALAAEVPEFHIWTVMGEHSAAQNALGRLEELVGGLVAAPRTRADAARDTLAALNRGVLGRPVVEADGLTAVRSPTVDRGYVEPHFRWAVMDRRSQPSREDWWSLQPEGTDLAGFLAAHFASPRAATLPLVVLGHPGAGKSLLTRVCAARLSTDAFTTVRIPLRDAPAGRIYRQVEDVLTETTHGKVEWRQLCEASKKRVRVLLIDGLDELMQATGATESNYLRDVADFQRAELEMDSPVAALVTSRTVVADTATIPQGCLVVKLMDFTDEQIDTWVQRWTEANAVAIREGHVRRIYPGALRTHDELARQPLLLLLLAMLASEQDLPEGATSAGLYRTLLDKFVARELDRPDVTGDDTNPEQKRRDELWKLGVVAFGMVNRGKQFLHEDDLAEDLRGLSSSRSARPPDPARRVIGRFFFVHTSEAEGGAGGRSYEFLHATFADYLIAHHAARLLREAATSWRTSGESQGWNDDLLFALLSHVVLGGSGSQSIDFFWDITDDPEELGPFLEHLVAAAHYRRRDNQFDSYDPSGRTVVQRIAVYTSNLVRLRVVLKQGPVAVAAFCPDDVEVETWWPAQVRLWEAVLSKTELETTIDYLSLDRSGVPTITWESTEGYYEDTLPWLALDRKNVIRSAAARGLLQPHYYEELIAPVGSDIADAAENLGFALRSHFGGPHIEESFVVEDENHPDLTQLRRLEISVMAKFAADFSYADVVRMIDRVDVEAEIPTLDRALLVVQHPRLLMNVPDMNAVRDEYGLINIMFALARLVPDDGREIFEELIETSEANRGIAETPEGRAVASLPPELGRRLIPELAKSILARQYP
>NC_022657.1|WP_023561282.1|7291567_7292161_+|TetR/AcrR-family-transcriptional-regulator
MAPEDRRAALIAATVPLLYEHGLEISTRQIAQAAGVAEGTIFGVFNDKHSLVVAALMEALDPQPTLDAMAAIDAGAGLRERLSAAATLINERFARNARLMTAARSLALSPHSHPDATERMARSRHNLLEGLTEVIAPDAGELRRSPATVARMLLLFCGANTYGPFGDPRSFDGDEIVSLLLDGLLIAPAHRHHHGGA
>NC_022657.1|WP_084298224.1|7292164_7293901_+|ABC-transporter-ATP-binding-protein
MLVRLLRAQLRPYGKSILLVVLFQFVATLATLYLPTLNADIIDNGVVPGDTGYVMQVGLEMLGITLLQIASQVAAVYFGARTAMAVGRDIRAGIFSKVLSYSAREVDSFGAPSLITRTTNDVQQVQMLVLMTFLLMVSAPIMCVGGILLALHQDVPLSSLLLVIVPLLVAVVAAIIVRMRPLFRTMQVRIDKVNRVMREQIAGIRVIRAFVRDDRERVRFGGANEELTDVSLRVGKLMALMFPTVMLLVNISSVAVLWFGGHRIDDGSMQIGALTAFLSYLMQILMAIMMATFMFVMIPRAEVCAERIEEVLDTPSSVEIAEHPVTELSRHGHLELRDVDFHYPGAEAPVLSGINLTARPREITAVIGSTGSGKTTLLNLVPRLFDATGGTVLVDDVDVRALDPALLSKTVGLVPQKPYLFSGTVASNLRYGNPDATDEELWTALEVAQARDFVQRMDGGLDAPIAQGGTNVSGGQRQRLAIARVLVHRPEIYLFDDSFSALDYATDAALRAALTAHIADATVVIVAQRVSTIREADRIIVLDDGHVVGSGTHTELMDANPTYREIVLSQLTEQEAAA
>NC_022657.1|WP_041841342.1|7293897_7295856_+|ABC-transporter-ATP-binding-protein
MTAPARRPAGPPMGGPGRMMAGGMPTEKLQDFKGSTKRLLKMLKPQRMLVALVTLLGIASVTLSVIGPKLLGHATDIIFDGIVGKGLPAGVSKAEIIARLRAEGQTNRADMLASMDVIPGQGIDFTRLQHVLLWVLVIYLFAWVFGVFQGRLTATVVQRVVFRLRNQVEEKLSRLPLSYFDQQPRGEVLSRATNDTDNIAQTLQQTFSQLVTSLLTIIGVLVVMFWISPLLALIALVTVPVSVWLTTAIGKRSQPQFVAQWATTGKLNGHIEEMFTGHSLVKVFGRQNEAAETFRTHNDRLYASSFRAQFISGLIQPAMMFISNVNYVLVAVVGGLRVASGSLSLGDVQAFIQYSRQFSQPLTQVASMANLVQSGVASAERVFALLDAPEQSAEPETSPVTGPVRGRVAFEDVSFRYAPEKPLIDNLSLAVEPGQTVAIVGPTGAGKTTLVNLLMRFYDVTSGRITLDGVDIATMPREELREHMGMVLQDTWLFGGTIYDNIAYGADHPTPESVAAAAEAAHVDRFVRSLPDGMDTVIDDEGSNVSAGEKQLITIARAFLAKPSILILDEATSSVDTRTEVLIQRAMNTLRAGRTSFVIAHRLSTIRDADVILVMESGAIVEQGTHDDLIAANGAYARLYSAQFAQAAVDMD
>NC_022657.1|WP_023561285.1|7295912_7298798_-|hypothetical-protein
MRYSPAHAAKSGSVPFMLRGPKSAKTILSAAVAGVVGLVPAVLIASPAMAAVTYTWTDSTPNATEAQPVTAELTWADSDPLGTAPTTYTWSTAEGTAKAGYDFTPVTGATVTFTNGKANFSVTTLADTVYEGDESFDIVVNNGNVAVATATATINDEDIAPTYTMTANKTTVTEGTDTAVTVTVKLDAASAAPVSIPITTEDGSGANGAKAGSDYTTYSTPVTFAPSETTKQFTVPILNDTTDEDDQTFTIKASAGTGVTGTASPITITIADEDAAPAVKFNSATASIEEGKDLKFPVSLTAPSEKTVTVKYDTSDLTAGAQPNGEGLASAGKDYTAVSAGVVTFAPGDTLKDAVVKTTTDDLDEITPEDFQATLSAPTNATLGMPATSIGKIADPNTTTSPTVTLTPTTVKEGNATASQTFTVKLSKASGKTQVVHWIAGTGLGQTATANADYKSASGDLTFAPGDLEKTFSVDILGDLTDEPDENFTLTLSNKDVASTLSNVSGDLKANTILITDDDDKPTYSVNNVSMAEGNTASVALYTLKLSNPTSTALTFNVTKVDDTAKSAPVGDPLTVFGTDDYSVPVGTVTVPAGQPAGYAFALVNGDGIFEPDEAASLKFTPADVATTGAVTGASATGTLTLTNDDTAPVLNVVPVSGNEDDTVTVKGIVIGQSQAEVSLNVSFEGKSVGGTKAASADDFTNPGAQLVKIPVGTPVGAQIKIADVKLTKDSVAEPAETILVSGFGLSNTGSVKDGAITIAANGTTTPDPDPEEPGEDSITLDSSSDFRLGVGNITLSGKTTPGAKVQPWAQPLDSDAGLVEYGSEVTADSSGNFSFVGKFTKTGYKFAASINDGDLTSDPVTVFLKQDPDLFLRSSSRGQATLSVFGDPRVAGLSVRFLRANSNGTWSTVATGSLDSTGKLSRTLTGLKSGASYLYKVTVYGDGDVGLLTNTSKSARVTIR
>NC_022657.1|WP_023561286.1|7299264_7300479_-|hypothetical-protein
MLRKVTAVVVTLIALVAAGRLATPQDRSGVRPQLAFLRAELDDGAAAEAQKLFPEGYFFLYALYGLARAELGDADEARWALSRLETPAGREPFSASLTPAYGVFYQGWTNWLRGAVLSLRPDPALQRDFETASAALAAAFDASPTPYLAAYPGQAWPVDSTVAIASLSLHDKILPPRYAPTRARWLAGVRDRLDPVTGLLPHTVDVRTGAPTSVARGTSQSIIQRFLVDIDPAFARSQYELFRSQFVVQPLRLGPAVREYPLGTDGPADVDSGPLPLGISLSATAVTMGAAAVQGDSQLARSLANYGELVGVPVETPWTKRYAGGVLPIGDAFVVWSKTARPWVAGPPAPLPRALTWWWRVPFLALLALVTLLAWLQTLRPRSNEPPDRNVTSLRLPKGRRKAV
>NC_022657.1|WP_023561287.1|7300521_7300848_+|TfoX/Sxy-family-protein
MAYDEALAERVRERLGVLPGVSDKRMFGGLAFLTEGNLTVCVTGDDLMVRVGKDTYDQALTLPGVRPVDMSGRPMRGWVVVDGAELDDEVLDGWLDRASVFVRALPPK
>NC_022657.1|WP_041841343.1|7300949_7302311_+|alkaline-phosphatase
MNVLRQLRGRRAAVVLAAAAIVAVPAVALAGDSHPDRTQAAKHAIQGGKARNVILLIGDGMGDSEITITRNYQVGAAGRLAMDKLPLTGAYTTYAVQKENPSLPEYVTDSAASGTGWATGHKTYNGAISVTPDGKPKPTILELAKQAGFRTGDVTTAELQDATPAVLGSHVVNRDCKGPDAMATCAVNDKVNGGAGSIAEQLVQTKPDVLLGGGKQFFDQTVKAGRYQGLTVAQQAQVNGYQIVTDATGLAAAKPGKPILGAFAKNNMDLEWVGPAPTRTGTAPAKCAVNTARTATQPHLVDMTGKAIDVLDKQTRNSRKGFFLQIEGASIDKQDHAANPCGQIGETVAFDAAIKKVLDYQKSHPDTLVVVTADHGHTSQIVEAPTMGYTATLTTHDGANMTISYATSEITGSQQHTGTEVRIAAGGPQAANVLGVTNQTDLFFTMKRALGVR
>NC_022657.1|WP_084298225.1|7302351_7303875_-|sugar-transferase
MTTTETTADNAATGPIPTTSSFAGFTDRDLGVAGVQDHEHADRWAWEARYIKLLLGIDFGATLIATLAAFALRFRGASYANWYLALSVLIPLVWVGLLALSHAYERRLLFVGGEEYQRVLRAGVRLTLVLALASYVANADLARGYLVIALVLTTVFSLAGRFALRKVLHRARRRGDCMHRVLVLGHAIAVSQVTSQLHRRSHHGLQVVGACLPADQLGDAARVVDVPVFGSLAAAANSAAAAGADTVVVLSCPELDGPMLRRLAWDLERDDIDLIVSSALVDTAGDRITVRPVDGLPMMHVEHPRLSGGRRLIKSVFDVSVAALLLVVFAPLFALVALLIRLDTGGPVFFRQVRVGRGGQSFGMYKFRTMHTDAEARLQAMRAENEFSDVLFKIRDDPRVTRSGRILRRYSLDELPQLFNVLLGEMSLVGPRPPLPAEVEQYPQDMRRRLVVKPGMTGLWQVSGRSDLSWEDSIRLDLRYVENWSLTVDLVILMRTAMVVLRGSGAY
>NC_022657.1|WP_023561290.1|7304369_7304591_-|ferredoxin
MSTERLHVDWTACDGRGLCAELLPELLVEDDWGYPVARSGESEPTVPPHLAGPARRAVDRCPALALRLVRSAL

Crispr_ID: NC_022657_11

• CRISPR_ID: NC_022657_11
• CRISPR_location: 7646825-7646920
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_022657_11

Consensus_repeat	Method
AGTGCGCCTCGGCCGGAGCGACGGTCAG	CRISPRCasFinder

spacers of NC_022657_11

>11.1|7646853|40|NC_022657|CRISPRCasFinder
ACCCCAGCGACCACGACATGCCCTGGACTTAGGTCTCAAG

CRISPR arrays and Neighbor proteins around NC_022657_11

CRISPR arrays

The CRISPR arrays of NC_022657_11

>merge|NC_022657|11|7646825-7646920|CRISPRCasFinder
AGTGCGCCTCGGCCGGAGCGACGGTCAGACCCCAGCGACCACGACATGCCCTGGACTTAGGTCTCAAGAGTGCGCCTCGGCCGGAGCCACGGTCAG

>NC_022657|11|9|7646825-7646920|CRISPRCasFinder
AGTGCGCCTCGGCCGGAGCGACGGTCAG	ACCCCAGCGACCACGACATGCCCTGGACTTAGGTCTCAAG
AGTGCGCCTCGGCCGGAGCCACGGTCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_041843150.1|7637903_7639184_+|HlyC/CorC-family-transporter	unknown	unknown	gnl|CDD|224173
NC_022657.1|WP_023561596.1|7648190_7648769_+|hypothetical-protein	unknown	unknown	gnl|CDD|227231
NC_022657.1|WP_148308174.1|7644209_7644422_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561600.1|7651681_7652059_+|DUF3037-domain-containing-protein	unknown	unknown	gnl|CDD|378608
NC_022657.1|WP_023561588.1|7639180_7641487_-|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl|CDD|224471
NC_022657.1|WP_041843149.1|7636603_7637335_+|dethiobiotin-synthase	unknown	unknown	gnl|CDD|234625
NC_022657.1|WP_023561591.1|7643135_7644044_+|YegS/Rv2252/BmrU-family-lipid-kinase	unknown	unknown	gnl|CDD|224513
NC_022657.1|WP_148308336.1|7654853_7656407_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|312032
NC_022657.1|WP_041843152.1|7650929_7651685_+|aminotransferase-class-I-and-II	unknown	unknown	gnl|CDD|270694
NC_022657.1|WP_084298241.1|7637331_7637802_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NC_022657.1|WP_023561593.1|7644532_7645399_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561601.1|7652047_7652407_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561589.1|7641479_7642370_-|carbohydrate-kinase	unknown	unknown	gnl|CDD|238579
NC_022657.1|WP_023561598.1|7650341_7650893_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561590.1|7642508_7643087_+|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|376570
NC_022657.1|WP_023561597.1|7648792_7650289_+|dNTP-triphosphohydrolase	unknown	unknown	gnl|CDD|223310
NC_022657.1|WP_023561595.1|7646940_7648071_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293841
NC_022657.1|WP_041841379.1|7645525_7645783_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561602.1|7652655_7653591_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235713
NC_022657.1|WP_023561603.1|7653701_7654769_+|ATP-dependent-DNA-ligase	unknown	unknown	gnl|CDD|236191

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_041843150.1|7637903_7639184_+|HlyC/CorC-family-transporter	gnl|CDD|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	5.1266e-103
NC_022657.1|WP_023561596.1|7648190_7648769_+|hypothetical-protein	gnl|CDD|227231	COG4894, COG4894, Uncharacterized conserved protein [Function unknown].	2.90562e-06
NC_022657.1|WP_023561600.1|7651681_7652059_+|DUF3037-domain-containing-protein	gnl|CDD|378608	pfam11236, DUF3037, Protein of unknown function (DUF3037). This bacterial family of proteins has no known function.	1.29943e-58
NC_022657.1|WP_023561588.1|7639180_7641487_-|glycoside-hydrolase-family-65-protein	gnl|CDD|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	0
NC_022657.1|WP_041843149.1|7636603_7637335_+|dethiobiotin-synthase	gnl|CDD|234625	PRK00090, bioD, ATP-dependent dethiobiotin synthetase BioD.	9.64865e-57
NC_022657.1|WP_023561591.1|7643135_7644044_+|YegS/Rv2252/BmrU-family-lipid-kinase	gnl|CDD|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	8.64106e-42
NC_022657.1|WP_148308336.1|7654853_7656407_+|alpha/beta-fold-hydrolase	gnl|CDD|312032	pfam08386, Abhydrolase_4, TAP-like protein. This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans. A member of this family is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterized from Propionibacterium freudenreichii.	8.20738e-27
NC_022657.1|WP_041843152.1|7650929_7651685_+|aminotransferase-class-I-and-II	gnl|CDD|270694	cd05124, AFK, Catalytic domain of Actin-Fragmin Kinase. AFK is found in slime molds, ciliates, and flowering plants. It catalyzes the transfer of the gamma-phosphoryl group from ATP specifically to threonine residues in the actin-fragmin complex. The phosphorylation sites are located at a minor contact site for DNase I and at an actin-actin contact site. Fragmin is an actin-binding protein that functions as a regulator of the microfilament system. It interferes with the growth of F-actin by severing actin filaments and capping their ends. The phosphorylation of the actin-fragmin complex inhibits its nucleation activity and results in calcium-dependent capping activity. Thus, AFK plays a role in regulating actin polymerization. The AFK catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.64251e-06
NC_022657.1|WP_084298241.1|7637331_7637802_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.29132e-15
NC_022657.1|WP_023561589.1|7641479_7642370_-|carbohydrate-kinase	gnl|CDD|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	5.2692e-54
NC_022657.1|WP_023561590.1|7642508_7643087_+|GAF-domain-containing-protein	gnl|CDD|376570	pfam01590, GAF, GAF domain. This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.	6.54419e-10
NC_022657.1|WP_023561595.1|7646940_7648071_-|MBL-fold-metallo-hydrolase	gnl|CDD|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	2.76675e-73
NC_022657.1|WP_023561597.1|7648792_7650289_+|dNTP-triphosphohydrolase	gnl|CDD|223310	COG0232, Dgt, dGTP triphosphohydrolase [Nucleotide transport and metabolism].	4.55701e-64
NC_022657.1|WP_023561602.1|7652655_7653591_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|235713	PRK06139, PRK06139, SDR family oxidoreductase.	2.16665e-73
NC_022657.1|WP_023561603.1|7653701_7654769_+|ATP-dependent-DNA-ligase	gnl|CDD|236191	PRK08224, ligC, ATP-dependent DNA ligase; Reviewed.	0

Protein sequences

>NC_022657.1|WP_041841379.1|7645525_7645783_+|hypothetical-protein
MIPAGHDFAAPRHRDTSAWIAVAAVLAEGLRYDGFETCGCARQPKFRPRTSPQIRQRRRLATRRGLPFATLLTTRDPYDTPPPIK
>NC_022657.1|WP_023561593.1|7644532_7645399_+|hypothetical-protein
MMWTARPDEVTALGSMLDRTYAEVAEAGHRPSTLDRPRLLRQLDLWTDHLLPAVAAANAPLRTRRAAGLSVWHTMHASDPDSEQWLRTNVATVPARTLGPQLTRLVDAQLHLIRRLQTIRRAENVRRCELAAIGALCAGLGTDTIRIASAVARSEHAAERRLQTLLDATLSALPAAPGPRTPSPQRITVGTAATLFAGLDVTRLRLLEHTDRTVLHLEAHRPAEARDTLVILVLTDAEDPKPLDIPEDGITLTAAPQLTATADDIDLTLPLTTGEWTVQAAAGTCYTD
>NC_022657.1|WP_148308174.1|7644209_7644422_+|hypothetical-protein
MSVAAVMTAATVIVIGYRLGRAHAAWRDLRSAKRDIPAKRKLAWGHTRPLVWGALFLLGTFVAAAYDAAH
>NC_022657.1|WP_023561591.1|7643135_7644044_+|YegS/Rv2252/BmrU-family-lipid-kinase
MRTPRKIAVVAHQRKTLGGGLDELRRLITDEGVDELDWHEVPKSRKAPKQVRKALAGEPDLLIVWGGDGMVQRSLDALAGTKGGAKVPVGIIPAGTANLLATNLGIPHDLHEAVRIAFHGARHKLDLGILNGEHFAVMAGIGFDGAMIQDADGKLKDRLGKLSYVWTGLRHLDGPAPKAKIKVDGTSWFSDDASCVLVGNVSKVTGGIKAFDDAKPDDGWLDVGVATARNAADWARTMSRMAVGRSENSPFVHMTRARRIDVRLAEPLTYELDGGAREAVKRIRIDVAPAAVKVCVPEERIG
>NC_022657.1|WP_023561590.1|7642508_7643087_+|GAF-domain-containing-protein
MTNSSPVSGQAFEYLDNVSPEEQRRLEAVRRYRLVDQPVEDAYDRIAFVAGAIFDTPIATVSLVEQDRVWLAACQGLSGVREVGKEPGLCASVIAQDDVYVINNAAVDPRTLEHPLVRGELGLRFYAAAPIRTHDGYRLGTVNVIDNRPRDASKRQLTALEHLAAMVSDELELRLMVIRSAAAEQRMRETVH
>NC_022657.1|WP_023561589.1|7641479_7642370_-|carbohydrate-kinase
MKPPVATVVGQLARDLVLSVGAVPDTGAAADATDRREQLGGKGANQAVGLAQLGVVPRLVAVAGEDIIGDVLLDQARRDGIDVTAVVRRPGALTGLIVELLDSDGQWRYVQHLSEEVLLTVRDVERARDVISGADAVLVQLQQPAAAALAAARIGHDAGRLVVLDGVPEEHRDELLAAADVVRADDQEARLLLDGPVTPAAARRLLDDGPRLLALGVEDGNLFVWKDGHVRLPLTGGKPVDTTGGGDAFTAALTASLLRGEDYSLAARWAVAASGATVTHVSGRPSLAGLQVSADG
>NC_022657.1|WP_023561588.1|7639180_7641487_-|glycoside-hydrolase-family-65-protein
MGEIGPAEPWVVREIGLPDELRQAESVFALANGHVGLRGNLDEPEPFGMPGTYLNSLYEHRDLTYPEAGYAFPERTETIIDAPNGKLVTLTVDDEPFDVRTGDLRRHERCLDLRAGTLHREVEWGPVRITSTRLVSFPHPSVAAIRYEVEALDRPVRIRLDSDLLANEEQPEPRDDPRASAVLHAPLRSLSHSDDVLVHRTRRSGITVASSVAHVSEPGEVSAEEDRIRFTLTTVVHPGTPLRLDKFVAYAWGTGDSDDDLAGTAVRDRDEAVRAGFETLLDEQRDYLDDFWDSADVELDGDPEVQQAVRFGLFHVLQAGAQAGPHPIAAKGLTGNGYDGHMLWDTESYVLPVLTYTHPACVGLALRWRHAALPAARERAAELRLAGATYPWRTISGAECSGYWPAGTAALHVNADIADAVLRYAAAAGDDTFVREAGLEILVETARLWCRLAHEDDAGVFHLDGVTGPDEYTALVDDNIYTNLMAQRNLRGAAQYCELFPERARDLGVSADEPRAWQETADNLALPYDNRREVHEQHAGFARLQEWDFASTKDDDYPLMLHYPYLDLYRRQVVKQADLVLAMVLRGDAFTPAEKTRAFEYYEARTVRDSSLSAPAQAVLAAETGYLELAHDYLAEAALLDLRAGGEASGDGLHIAACAGVWMALVQGFGGLRDHDGQLSFAPRLPSHLPRLKFSLRWRYSRLHVTVTPTTVTYAVTDEDLSFHHYGEPVDLKAGTTVTLDLPPVEEKAAPPAPAGRAPARRRDALDR
>NC_022657.1|WP_041843150.1|7637903_7639184_+|HlyC/CorC-family-transporter
MGGQVLLVLVLVLVNAAFSGSEMALVSLRDSQVNKLERQSRRGRVLGRLTRDPNRFLATIQIGITLAGFLASAAAAVSLSKPLVEPLGFLGSAAEPAAIVVVTIVLTFVTLVIGELAPKRIAMQRTEGWALLVARPLDILSTISRPAVWLLSVATNLLVRLAGGDPKAQREEVSTEEIRDMVAAQQDFSVEQRTIISGAFEIADRILREILVPRRDVLTLATGLAAPEALTQLIAGGHSRAPVVGPAGLDDVFGVVHLRDLVGAQGPVDLVARPGLFLPETLRVSDALRQMRLERHQLALVVDERGAIDGIITMEDLVEEIVGEIYDETDRDVQSVVKEADGALLMPGSFPIHDLPDIGFDNSVPDEGDYTTVAGMVLASLGHIPTEPGEVVTLPQFTAEVVEVTGRAITRLRLRALPREEPEDED
>NC_022657.1|WP_084298241.1|7637331_7637802_+|GNAT-family-N-acetyltransferase
MMEISIVAAAPADAGEVLTVQRAAFLAEGALNDSFTLPPLTETLDEVRAAIDDTGLVFLVARQEHRLVGSVRGRVTDGTGHVSRLSIAPDLQGQGLGRRLMTAIEQALAGQVQRFELFTGATSAANLALYHKLGYVDCGWGPGAAAAGITYLEKRV
>NC_022657.1|WP_041843149.1|7636603_7637335_+|dethiobiotin-synthase
MEAGEWRGIVLVTGTDTDVGKTIVTSAIAASAQAAGLRVAVVKPGQTGTAEGGPTDIDRVTHLANPHTTRTLASYPEPLAPLAAAKISGLAPLELYEVVDAVRAEGEKHDLVLVEGAGGLLVPMGVRPSGEAWTVADLATTLGVPTIVVSRAGLGTLNHTALTLEALERRGVAAKVVLGAWPAEPELVHWANLTELVPHLVGALPDGAGGMEPGVFQRSAPGWLTPALYGVLDDWRVWADEVS
>NC_022657.1|WP_023561595.1|7646940_7648071_-|MBL-fold-metallo-hydrolase
MAKQANSRRGRTGAWIALALGAAAVWAARDVPLQMGSRKIGAKADGERGERYRRSPQFADGKFVNTVPAVQPAAAAMPRIVAASLTDRDRRHPSAPIPVIRPEPGDASGLHVTWYGHSSALIEIEGRRVLIDPVWSERCSPSRLTGPKRLHEPPIALRELPPIDAVLISHDHYDHLDMDSIRNLVDLQAAPFLVPLGVGAHLERWGVPATRIIELDWNENATVAGIDFTATAARHFSGRGFTRDETLWSSWVIAGPTRKAFYSGDTGYFPGFAQIGEEHGPFDVTLVQIGAYGDAWPDIHMLPEDGVATHVDVQGGLMIPVHWATFNLALHDWPEPADRAWREAKARDVKLAVPRPGERVDVDNPPAVDGWWQQIA
>NC_022657.1|WP_023561596.1|7648190_7648769_+|hypothetical-protein
MTVDTLQTQQQLIVRQRLRLMVNQYEVHAVGPDGSEAGVLAFAQQKRMAFKEQVTLYTDDTKSTPVLGFKARQRLDLAATYDITDAAGSPIGLFRKNFKESLLRSTWHLEQPGYGEMVGRETNMTVAILRRFVDSLSWLPYHFEFLLNDRPAFSVVKKWGLRDKYVVTIHDPQLDRRLVAAMAVALDALQSR
>NC_022657.1|WP_023561597.1|7648792_7650289_+|dNTP-triphosphohydrolase
MDDPRARRLFGDSLVAPGDLAASPFRVDRDRIVSSPFFARLAGVTQVISPGGAGLLVHNRLTHSLKVAQVGRAIAERLLRDQHFSDVLEKLGGCDPDVVEAAALAHDLGHPPFGHLGERVLDQLARQRLRLRDGFEGNAQSYRIVTSTEIRGEATIGLNLTAATRAAILKYPWTRRTHPAPHPRHLDPPPRGAAAPPDDPDGGSLKFGAYSTEVEDMVEARLPFAGRVADWQQTAEASVMDTADDIAYAIHDLEDVHRVGVLQQGAVAAELMAWQRSSFRDVPDEELALTQRRPGHAIEALRRQLHRKDSWVSNDEAFAAAVEQVRAELVDGLLSAPFDGSLEAEAQVAAFSATWTRRLVESIEATGSPAVRSGHVLLAPVQWHEVQVLKFVQNRFVLARPDLALHQRGQARLLSNLVEALLAWLADPAETERLPRRIHDLVELAEAELPDGTPDRVARARGRAIVDYVAALTDSQAVALMEALSGRTRQLWTDAFVL
>NC_022657.1|WP_023561598.1|7650341_7650893_+|hypothetical-protein
MRYRPPSGARTEPPPADDAAAWITGASPDGWFTEPPEVIVDRDEIIIWGRVPTPELSADATEADRAAAQAGRIHQFREDTRDDRIKVALQVEHRYQRKVSWGVRCGDTQDLFTHLSAPVMTRLRQPERQVLDTLVDAGVARSRSEALAWCVRLVGEHTEDWLTELRSAMTKVEDLRRQGPATA
>NC_022657.1|WP_041843152.1|7650929_7651685_+|aminotransferase-class-I-and-II
MLPEVTAIRYVTPLREGGSLPGIVEADNLGTYVVKFRGAGQGPKALVAEVISGELARRLDLPVPELAVTHLDPIVARAEPDEEVQELIKASAGANLGMDYLPGALGYDPVAHPVEARLASRTLAFDAFVENVDRSWRNPNLLVWHGELWLIDHGATLYFHHNWPRAEKVVHRAYKWDDHVLRPYATELATAGPELAAQLTPQVLEEVIGLVPDEWLEEFDFATADEARAAYLGHLRERAADPSAWLPGAAA
>NC_022657.1|WP_023561600.1|7651681_7652059_+|DUF3037-domain-containing-protein
MRIPYEYAIIRAVPRVERGELINVGVILYCQRLDFMAARTHLHEGRLLALDPNADLDGIRASLKSWEITCAGGADGGAAREMKLGERFRWLVAPRSTILQAGPVHMGLAVDPSAELDRLVELLVR
>NC_022657.1|WP_023561601.1|7652047_7652407_-|hypothetical-protein
MPAACRPAGLPAEPPAADTRLSREAVVYVTQESTPEQRNYIDAAIFRVMAAGPGNFYYDPLSPEFRRAYCGRAPLDPKIGPTLPYLYEVGLSSPGAFPALVNEVQGMPGVVGVRHALPD
>NC_022657.1|WP_023561602.1|7652655_7653591_-|SDR-family-NAD(P)-dependent-oxidoreductase
MVVLTGASSGIGRAAALAFAARGDRLVLAARGLADLEKVAASCGGSPLVVPTDVSVRAEVDELAEAAVDRFGRIDVWVDTAAVMAYGRFEDLPPEVFDQVVTTDLLGSANVARTALRQFRRQNHGTLILCGSLLGHITVPYMSAYSTAKWGQRALSRALRQETRDARDINVCQLVPGSVNTPIYTSAANYAGFVGRPPPPVDTAERMAAAVLKLANKPRRELSVGATNRLIEFGFKTMPPVYDALVGSMITRLGLSRRRVSPQQGNIFTPAPRVEGGPLRLGRGAVAAAAATATVLASTTVVAGVRLWKRS
>NC_022657.1|WP_023561603.1|7653701_7654769_+|ATP-dependent-DNA-ligase
MDLPINPPVKPMLAKPVADIPPGQLYEPKWDGFRSIIFRDGDEVEIGSRNEKPMTRYFPEVVQAVLANFPPRSVIDGEIIVADTARNTLDFEALQQRIHPAASRVKLLSEQTPAGFVAFDLLALGDEDLTTLPFAERRARLEQCLADAKPPVYVTPATDELETAQRWFAEFEGAGLDGLIAKAKDLEYVPDKRVMTKIKHKRTADCVVAGYRVHKSAENRIGSLLLGLFDERDVLVSVGVIGSFPMAVREELFTEMQHLVTTFEGHPWNWAAHEQGERTPRKNEVSRWNNGKDLSFIPLRPERVVEVRYDYMEGLRFRHTAQFERWRPDREPRSCTYEQLERPVRFNLADVLTSR
>NC_022657.1|WP_148308336.1|7654853_7656407_+|alpha/beta-fold-hydrolase
MVLAALVAAVVVTAGCTLPAFAPDDSDSAAPTTSGSKAPPAVPGTQAQWTPCPEVPQDLVGRGASGMSYDCASVAVPRDWNAPQSGETYDVAMIRIRSRTQQDRIGSLLINPGGPGGSGIDTSVYLSFGQALGGLPTAVTDKFDIVGFDPRGVGRSNPVKCISNEDQDATFAAPPDPESDAEFQELVALNKRVAEGCGAKYGAQLPLFSTEQAAHDMDAIRAAVGDPKTTYLGFSYGTLLGATYAQLFPDKVRALVLDGAINPKQDFIAGSESQAKGFERAFTNFTAWCKANAGKCPIAPDGRGAVTDALAKAKASPVKGTDGRSATAGWIFVAVISSLYTESGWQQLAKAVDDLQAGDASGIFELADQYADRKPDGSYSNLFDANLTVNCADTDDAPTVERIRQLQGEWRKKYPLFGATLAVGMLPCTFWPGKKDPYPVGPATGSPPIVVVGTTGDPATPYENTAELAKMLGTGQVLTWEGEGHTAYPSTKCIVDAVDGYLIDLKVPRVGLRCPPQ

Crispr_ID: NC_022657_12

• CRISPR_ID: NC_022657_12
• CRISPR_location: 7729852-7729999
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NC_022657_12

Consensus_repeat	Method
CCAACTTCAAGGAAGTTGGGCC	CRT

spacers of NC_022657_12

>12.1|7729874|20|NC_022657|CRT
CTCGTGAGCGCGTCGAAGCA
>12.2|7729916|20|NC_022657|CRT
TTCAAGGCGTCCACGAGCGG
>12.3|7729958|20|NC_022657|CRT
TTCATGACCGTCTCGAAGCA

CRISPR arrays and Neighbor proteins around NC_022657_12

CRISPR arrays

The CRISPR arrays of NC_022657_12

>merge|NC_022657|12|7729852-7729999|CRT
GCAACTTCAAGGAAGTTGGGCCCTCGTGAGCGCGTCGAAGCACCAACTTCAAGGAAGTTGGGCCTTCAAGGCGTCCACGAGCGGCCAACTTCATGGAAGTTGGGCCTTCATGACCGTCTCGAAGCACCAACTTCAAGCAGGAAGTTGG

>NC_022657|12|3|7729852-7729999|CRT
GCAACTTCAAGGAAGTTGGGCC	CTCGTGAGCGCGTCGAAGCA
CCAACTTCAAGGAAGTTGGGCC	TTCAAGGCGTCCACGAGCGG
CCAACTTCATGGAAGTTGGGCC	TTCATGACCGTCTCGAAGCA
CCAACTTCAAGCAGGAAGTTGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023561670.1|7722760_7725142_+|EAL-domain-containing-protein	unknown	unknown	gnl|CDD|227334
NC_022657.1|WP_023561679.1|7734208_7734907_+|metal-dependent-transcriptional-regulator	unknown	unknown	gnl|CDD|224240
NC_022657.1|WP_052359876.1|7718819_7719506_+|deoxyribose-phosphate-aldolase	unknown	unknown	gnl|CDD|234784
NC_022657.1|WP_023561678.1|7732854_7734039_-|acetoin-utilization-protein-AcuC	unknown	unknown	gnl|CDD|212520
NC_022657.1|WP_023561674.1|7726433_7727219_-|sporulation-protein	unknown	unknown	gnl|CDD|369195
NC_022657.1|WP_023561672.1|7725439_7726027_+|phosphotransferase	unknown	unknown	gnl|CDD|270690
NC_022657.1|WP_023561667.1|7718064_7718790_+|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225099
NC_022657.1|WP_023561676.1|7728581_7728935_+|YrdB-family-protein	unknown	unknown	gnl|CDD|378498
NC_022657.1|WP_052359877.1|7730293_7732792_-|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein	unknown	unknown	gnl|CDD|131764
NC_022657.1|WP_023561681.1|7735538_7735772_-|hypothetical-protein	unknown	unknown	gnl|CDD|379987
NC_022657.1|WP_023561673.1|7726014_7726437_+|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl|CDD|235383
NC_022657.1|WP_023561684.1|7737232_7738447_-|MFS-transporter	unknown	unknown	gnl|CDD|340951
NC_022657.1|WP_023561682.1|7735831_7736287_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561671.1|7725138_7725423_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561683.1|7736308_7737223_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_022657.1|WP_023561685.1|7738511_7739573_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_041843168.1|7727531_7728488_+|RNA-polymerase-sigma-factor-SigB	unknown	unknown	gnl|CDD|181169
NC_022657.1|WP_148308178.1|7719499_7722676_-|ATP-binding-protein	unknown	unknown	gnl|CDD|99707
NC_022657.1|WP_023561686.1|7739636_7740143_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561680.1|7734919_7735474_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023561670.1|7722760_7725142_+|EAL-domain-containing-protein	gnl|CDD|227334	COG5001, COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms].	3.86981e-109
NC_022657.1|WP_023561679.1|7734208_7734907_+|metal-dependent-transcriptional-regulator	gnl|CDD|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	3.1885e-47
NC_022657.1|WP_052359876.1|7718819_7719506_+|deoxyribose-phosphate-aldolase	gnl|CDD|234784	PRK00507, PRK00507, deoxyribose-phosphate aldolase; Provisional.	1.65651e-98
NC_022657.1|WP_023561678.1|7732854_7734039_-|acetoin-utilization-protein-AcuC	gnl|CDD|212520	cd09994, HDAC_AcuC_like, Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes. AcuC (Acetoin utilization protein) is a class I deacetylase found only in bacteria and is involved in post-translational control of the acetyl-coenzyme A synthetase (AcsA). Deacetylase AcuC works in coordination with deacetylase SrtN (class III), possibly to maintain AcsA in active (deacetylated) form and let the cell grow under low concentration of acetate. B. subtilis AcuC is a member of operon acuABC; this operon is repressed by the presence of glucose and does not show induction by acetoin; acetoin is a bacterial fermentation product that can be converted to acetate via the butanediol cycle in absence of other carbon sources. Inactivation of AcuC leads to slower growth and lower cell yield under low-acetate conditions in Bacillus subtilis. In general, Class I histone deacetylases (HDACs) are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase.	1.46837e-155
NC_022657.1|WP_023561674.1|7726433_7727219_-|sporulation-protein	gnl|CDD|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	2.49893e-117
NC_022657.1|WP_023561672.1|7725439_7726027_+|phosphotransferase	gnl|CDD|270690	cd05120, APH_ChoK_like, Aminoglycoside 3'-phosphotransferase and Choline Kinase family. This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	4.60555e-15
NC_022657.1|WP_023561667.1|7718064_7718790_+|GntR-family-transcriptional-regulator	gnl|CDD|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.84232e-60
NC_022657.1|WP_023561676.1|7728581_7728935_+|YrdB-family-protein	gnl|CDD|378498	pfam10823, DUF2568, Protein of unknown function (DUF2568). One member in this family is annotated as yrdB which is part of a four gene operon however currently no function is known.	4.26852e-15
NC_022657.1|WP_052359877.1|7730293_7732792_-|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein	gnl|CDD|131764	TIGR02717, Uncharacterized_protein_MJ0590, acetyl coenzyme A synthetase (ADP forming), alpha domain. Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.	2.96827e-106
NC_022657.1|WP_023561681.1|7735538_7735772_-|hypothetical-protein	gnl|CDD|379987	pfam17653, DUF5522, Family of unknown function (DUF5522). This is a family of unknown function. Family members are found in Bacteria and Eukaryotes. In algae, this family is found on the N-terminal of diphthamide synthase family pfam01902 and is predicted to be a membrane transporter belonging to The ATP-binding Cassette (ABC) family. In nematoda, it is found on the N-terminal side of ribosomal protein family L14 pfam00238. It is also found on the N-temrinal of Cob(I)alamin adenosyltransferase pfam01923 in other eukaryotes. Family members found in homo sapiens have been shown to be highly expressed in 15 high-grade neuroendocrine tumor cell lines and YAP1-positive small-cell lung cancer cell lines as well as being up-regulated in two human Multiple Myloma cell lines in response to selective nuclear export inhibitor KPT-276. The HMM profile of this family reveals 4 highly conserved cysteines.	1.56528e-18
NC_022657.1|WP_023561673.1|7726014_7726437_+|D-tyrosyl-tRNA(Tyr)-deacylase	gnl|CDD|235383	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional.	2.8956e-76
NC_022657.1|WP_023561684.1|7737232_7738447_-|MFS-transporter	gnl|CDD|340951	cd17393, MFS_MosC_like, Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters. The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.23075e-71
NC_022657.1|WP_023561683.1|7736308_7737223_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.84838e-22
NC_022657.1|WP_041843168.1|7727531_7728488_+|RNA-polymerase-sigma-factor-SigB	gnl|CDD|181169	PRK07921, PRK07921, RNA polymerase sigma factor SigB; Reviewed.	7.49183e-170
NC_022657.1|WP_148308178.1|7719499_7722676_-|ATP-binding-protein	gnl|CDD|99707	cd00009, AAA, The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.	0.00991145

Protein sequences

>NC_022657.1|WP_023561676.1|7728581_7728935_+|YrdB-family-protein
MRAINLLLRFVLELCALAALAYAGWQLPGAVWLRLLAAIALPLVAALVWAQWVAPKARRPVADPLRLVPEWVVFGGATVALAVTGHVILAGLLAVLAAANRLALHLLGAPTDDHAPV
>NC_022657.1|WP_041843168.1|7727531_7728488_+|RNA-polymerase-sigma-factor-SigB
MTDGVEPLADLDATDERGVSADLVRAYLNGIGRTRLLTAVEEVTLSKRIEAGLYADEKLPAAGSDLAPLLHIIIAEGRAAKNHLLEANLRLVVSIAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEQVNRMVRARRDLAATLGREPGVAEIAQAMGVPEFQVIELISYDREPVSLDQAVGEDGESALGDFVAAVDHRADPGDTAGRSELRGEVEIVLSTLSERESAVIRLRFGLDDGRQRTLDEVGREFGLSRERIRQIEKVTMSKLRDPQRAGRLEAYAS
>NC_022657.1|WP_023561674.1|7726433_7727219_-|sporulation-protein
MVFKRMMQAMGVGGPSVETVLANPNCRPGGFLEGQVHVMGGDHAVDIEYVAVGLMTRVEVESGDSEYNTDQEFHRQRLTGSFKLDAHARHDIPFRFDVPWETPITEVYGQHLHGMTMGLRTELEVARAVDKGDLDAVAVHPLPAQERILDAFLRLGFRFSRADVERGRVHGVHQTLPFYQEIEFYPPSQYAGRINQLEVTFIPTPHQLQVVLEIDKRGGLFTEGHDSFGRFDVDYHTVDQVDWTAQLNGWLQQSSQRRGFF
>NC_022657.1|WP_023561673.1|7726014_7726437_+|D-tyrosyl-tRNA(Tyr)-deacylase
MRALIQTVSRASVTVDDEVVGKIENGLLVLLGVTHDDTSTIAENLARKVHEMRILDGDASAADTGAPLLVVSQFTLYGDARKGRRPTWSAAAPAEVAEPLVTAFVEALRERGATVETGRFRAHMLVESVNVGPRTVWLET
>NC_022657.1|WP_023561672.1|7725439_7726027_+|phosphotransferase
MTGPLIASGREADVYALDERRVLRRYRREADVTGEVATMRYLAGAGYPVPEVFSASGRDMIMERLDGPTMAQAFAEGSIGVEEGAAQLAGLLSHLHEISPILHLDLHPENVLMTSRGPVVIDWCNARTGDPDLDTGLSALILAQHAPLPVLAAFLRVAPGQPTRLLDEVVRFRDRQLSGTEDLSPAVERLLACAP
>NC_022657.1|WP_023561671.1|7725138_7725423_+|hypothetical-protein
MSDNSDYAPETLDEPSTSRPEKGNDDPGLSSTIAAGTDTDQLINGGPPPRDGGAVTTTGGTAGPNSFRPKARHGEGVANTTTGDATTGSMEPTD
>NC_022657.1|WP_023561670.1|7722760_7725142_+|EAL-domain-containing-protein
MTASDRRRWAGLVLVFLVLLGGAGVSGAATVAVSRAEQRYADQAMNRYSDLVEGAVLDEVRHYGDALQDVAAAINAQTEFTYGDFTGITSYLTSARLPGASSLAFIVTGTDSQVPALQGFWREQGAAGLVLAPQGRGVEHAFVVFSRSFDMRPLRPGIDLNQAVQPFQALVEARRTGQVTMSEAYVLLKDRSLPRAEQQMSFIMTAPVYHGFDADGQPALRGWVLLGVHGRDFLNTTLQVHTQGAVTAVLDDHHGTSDIPLVSVGTTKHGPDTAQKRILEVGGRQWRLTVHPTAQLLGATDRRIVGLTLAATIAITLLLTVLVAILTSARNRAMTRVDQATAALRGDIERRQEVETRLRERESELQRLALHDSLTGLANRTALDSRLTAAVAAGEPIGLLLIDLDGFKPINDVYGHAAGDQVLTEFGRLLSDTVRTGDTVARIGGDEFVVLLADIPDATEAAVAAQRILAAATARPVRLGDDTLPIRASIGVTTARTGDTAKEVQRRADVAMYHAKRAGSHGMAVHDPSMTDRRAADAALGEDIAVALERGQLHVVYQPIVDLEDGRPLAAETLLRWQHPRLGPVPPDQFIPIAERNGAINAIGLWVLDQACRQAVEWDARYVSVNLSPRQLQEPTIVHDVLAVLRRTGLDPERLVLEVTESAIVDENAGIPALRALRSYGIRIAIDDFGTGYSSLHYLTRMPVDILKIDRTFVNELNGTSEGAAVTEAVIRLSQALHLTTIAEGIETEEQAAELRELGCTRGQGYLYARPHPAEELDWNRFATSPSGQPCTP
>NC_022657.1|WP_148308178.1|7719499_7722676_-|ATP-binding-protein
MARGLRYADAVRLLGGASPAIKAADTLLGGALTIATAGGSDAALGLFDAKAEVIRLGHVVAGKVHDSVRGQARHDRSSRLQAAHGILVVSSFFEAVDEIIAATELDPPELTRDDQVLLVAGTPITGDWLRDLLGAPVPVPSAERSAVGLLDDLRDWYLREALHFGTYLQGLAAWERADQRSRRAVQRLLSEVLPAAALRRYEDSRRALAIDVPEFGLWVRRAEDRAVGRSLIELQEVLERTTSARDPDRRRRALAAAYRVELDKPVTGEASPELMIPALGEAYLDPLFRVKAAGPTARPAEHSWWDADIRSDFAAFLAEHLTTPQAAEAPLLLLGQPGAGKSALTRVLAARLPAADYLVVRVALREVPAEAEIQDQIEQAIRTTIGETVAWADLAATADGALPVIMLDGFDELLQATGVHQSDYLQRVARFQEREAVQGRPVAVIVTSRVAVADRARLPDGTLIARLEGFDDARVARWLRTWNSLNPTRAVQPEVVQRYSELCMQPLLLLMLVLYDATTGALREDTTFDTAQLYERLLHRFAEREVRKLHAGEPEPRMAGLVEAELTQLSVVALAMFNRLRQTVTQQDLDADLAALGLTTGRRAESEGFRSSLTAGEEVVGRFFFIQRSEALQDGRQLRTYEFLHATFGEYLVARLVVRTVRGNAARAAADDSPLGPATTDEGVLPGLLSYVPLIARGTVLPFISSMLATSKHEEIRSWLIDVLRVAMIRPEPARGRYQPVDKRVDHMMATYSLNLTLLVIACGKPLPASEIFVHAADPAAWFQGAAQQWLAAVPSGMWSAFAETVSIRKTWAGERRDLVLHRAAGLTPIPVDLLWTFPGIGHLADTSQPGVGLGVDSIDQMNSLLQLMGQEGGDVMLHAVEPLAAELPRSLTTFVVHEAGEVESIARSLTRVWLTSSLDGTTADLVEAYHRAVRAVEGRMWDPNEFDPSLVPAIRVVLRLLTADVTRIPAVTLDEWLLRLVTSPYFTQAHVPDALEFLVAASPIVDIRTMAERVVGKHADGTTKWSPADEIRVFRALRELQRCLPDSELDIRREPDQ
>NC_022657.1|WP_052359876.1|7718819_7719506_+|deoxyribose-phosphate-aldolase
MIDHSLLRPDLTVGEVRQGCELAASRGTKSVCVRPSDVALAVAALHGTGVLVGTVVGFPHGNTLTAIKVAETKALVEAGADEIDMVLDIGRLRSGDAAYVRDDIAAVVQAAGGRCVKVIQENAYLTNDQKVLGCRLVEEAGAQFVKTSTGFAPGGATLADIRLMRATVSPAIEVKAAGGVRTLDTLLELVEAGATRFGATATAAILDDLAARHRGERTSVVAAADGAY
>NC_022657.1|WP_023561667.1|7718064_7718790_+|GntR-family-transcriptional-regulator
MANTPLYVRIERALRARLVTARPGDGVPAESALAEEFGVARMTVRAALNALEADGLIERIQGRGTFVRQRPAPRAAGTLMSFHDQVRSWGRRPSSRLVEGEVRPATAEEAAALQLTAVSPQVVAITRVRLADDVPLAVEYACFPPHLDGLLEADLETGSLHRALHERGVRPTLGSSTLTAQPAGRDGGRLQVPDGEPLLVETRLIVDQHAAPLEYTVSRYVGSRYSLQVAFDVQPPREGDV
>NC_022657.1|WP_052359877.1|7730293_7732792_-|bifunctional-GNAT-family-N-acetyltransferase/acetate--CoA-ligase-family-protein
MRPIRPDDAPAIVEFHSRMSDRTRYLRYFSPYPRIPERDLARFVNVDHRDREAFVIVSGPRIMAVGRYERLGPDAPEAEVAFVVEDAHQGRGIGSVLLEHLAEAAREHGITRFVAEVLPQNAGMLRVFSDFGYQVQRKYADGVVHLEFPIAPTEKSREVQESREQRTEARSISRLLHPRAVAVYGASASGQGIGAALLGHLRDGGYTGTVVPVHRSADRVAGLPAYRSAVAAGVAVDLALVAVPPEGVAEVLADAAAAGAGGLVVVSAGFAEAGAEGARAQRELIDSAHAAGMRVVGPNCLGIANTDPAVRLNATLAPALPAAGRVGFFSQSGALGVALLAEADRRGLGLSSFVSAGNRADVSGNDLLQYWQDDPGTDAVLLYLETFGNPRKFARLARRMSRVKPVVAVASATRPPGLAGDLPGPDTKAVTALFARSGVIRVDTVAELFDVGILLAHQPLPAGRRVAIVGNSSALSGLAVAACRATGLTVADGYPCDISPQAGAHDFADALADAAVDDRVDALVVVFAPPLPGQLPDEDADFAAALGSVALAGEKPTVATFLLGQLPPRVPAYPSVEEAVRALSRVATYADWLRQAPGALPALSGVDPSAPELQGPPTDLLAAYGIKVEPSSSAGSLDEALAAAETLGYPVALKAAGGALRHRIDLGAVRLALADAEDVRAAYSELSQAFGPDVLVQSMVPAGVACTVEVVEDPAFGPVIGFGLGGVASELLGDLAWRAAPLTDRAAAALVDEPRAAPLLHGYRGSAPVDRGALIDLLLRVGRLADEHPQVRALSLNPVLARPDGITVLHASVELGEPGTRPDTGPRRLHTA
>NC_022657.1|WP_023561678.1|7732854_7734039_-|acetoin-utilization-protein-AcuC
MAESTAVVWDEALLAYDMGDHPMDPVRIELTMALARELGVLDRAGVQLLVPEPADDAALIRVHRPDYLEAVRIAPHDPFFRGWGLNTPDNPVFDGMHEASARICGATLAAAEAVWSGAATRAVNVSGGLHHAMAARAAGFCVYNDPAVAIARLLDLGAQRVAYVDIDVHHGDGVQTAFYDDPRVLTVSLHESPAALFPWASGFSTEVGGPGAEGSAVNVALPPGTGDAAWLRAFHAIVPSVLRAFSPQILVTQCGADAHRLDPLADLRLSVDGQRAAYIALRSLADELCDGRWVATGGGGYALVEVVPRAWTHLLAVATGAPLDPATETPPGWRKLAADRRPGTGIPTTLTDGIEPAVERWEPGTTPDPVDKAIMATRRAVFPLHGLDPHDIRD
>NC_022657.1|WP_023561679.1|7734208_7734907_+|metal-dependent-transcriptional-regulator
MNDLVDTTEMYLRTILELEEEGVPPLRARIAERLHQSGPTVSQTVARMERDGLLTVENDRHLLLTEEGRVAAVAVMRKHRLAELLLVNVIGMPYEEAHEEACRWEHVMSDSVERKVYELLNKPTRSPYGNPIPGLEVLGLPAEEPLGSSSTVINSGERNLAFPGLSGSVVVRRICESVQTNAGVLRQLHAAGIDPGATVTVAQERDGVTIDRSGDKIRLPREVASRVFVDAR
>NC_022657.1|WP_023561680.1|7734919_7735474_-|hypothetical-protein
MRSRLFALGAAVALLALAGCTDKEADAATLPPVQIVQQPAASAGGACILWDYAFIEEKLGVKFNVAAADQIDDTSTCVVQTERDDWPYLALSVVESTKADADLFTEELTPKKATKVKGLGKAGYRLISKATGGHGPTVEIGWLSEAAQLQTLRFTFAKEASGDDVKQMSPKLLSLAKAMDTTGG
>NC_022657.1|WP_023561681.1|7735538_7735772_-|hypothetical-protein
MDKRAPRALTEPHPARLSPAHPRRTDILEAHAAALEAGQAGYPDPDTGLFVLTAGFLAKRGTCCGRGCRHCPYVDDA
>NC_022657.1|WP_023561682.1|7735831_7736287_+|hypothetical-protein
MPSKKELVEQIVRLLDIRLLDPLEVLLEGDDAVEALRRLVRVRAARWADQMHDGDDVTAAGAAIRLIATLYPDDRAFDPPVDWWRTPLGAVVARRVGHPAAESVSYATAGAMLGITRQGVHDLVRRGRLPRHPDGGVPSAAVRERLLAQPE
>NC_022657.1|WP_023561683.1|7736308_7737223_+|alpha/beta-hydrolase
MINDRLIDAGQLPIAVRDFGGDQPPLLLLHGAGGNLAMMTTLARALRPRHRVITMDLRGHGRSGDGAWSWDAGLGDIAAVTVQMELDRPAVVGHSFGGMLATLWGQRHPESPGVVNLDGNPTPARPDQLPGFDAGQATAELARLTAAFDSMHAGMGATIPAETLPDLVERQQMAARDMGANEKVWIEGFRRNLVHKDGETTMRPSAETAGSIRSLMAELDLGPVYASTPSPTLAVLATRDIPAQEPFEELYAAYRKFLVEQAAAAAKANPRMRYLQLHDASHAMEIEQPALLASLIGDFLSGGH
>NC_022657.1|WP_023561684.1|7737232_7738447_-|MFS-transporter
MTDAALDRRRLESVKVAVGITFATNGLAYAGWLARAPAVREDLGLSSAGLGLLLLCISVAAIATIPLAGPLVQRFGPARAVLLGSMSVVFGLVGMAGGTLTGSVPLAGAGLVLLGMGNSTWDVAMNVEGADVERRLGRTLMPRFHAGFSLGTVAGAGVSAAAAAAGVAVSTQLFLTAILAAVVMILTVRRFLPHTPVTAEQRSTGRVRDAWREPRTLLIGVIMLGFGFTEGAANDWLAIGLVDGYHATETIGAIGFGFFVTAMTLARLFGGHAIERWGRVTVLRGTAASALLGLLLVVSGISVPFVLLGALLWGAGASLGFPIGMSAAADDPLRAAIRVSVAGSIGYGAFLAGPPLIGLLAEHLGVLRALLVVLVAIGLGLAASGAARPLALGRPAEDEPATRP
>NC_022657.1|WP_023561685.1|7738511_7739573_-|hypothetical-protein
MFRKSGELARACDVVNDVVARRDGSAFEPAMERLVRAIRKARAAELGDAVERLTPALDRVALSGGGALAQVVGAIAEENLSVLPVLVRRAAEAMEEAARFAALHREAIGEPPGSDFEPAIEPTLERVREAAPKMGLTGDEAVALAWTWFSGNDWVQPVLYLAQRKDVRVALPERERLTRVTTASTELLDTASWLLGLLQVLDDEPLIVLHRGTGRGYRVTISGVGDNFQLSTLLAARLMGPEAQGLLPGVPPTKAMIAAASDGEQEIRGGLVGQFNLVGADGQWIWNEGRPADIPVQDGVRVVVLDPLPYSRSWNSGRLYSRMSPTVTVDGPLEPAEAEAWLAKVAPANPTGL
>NC_022657.1|WP_023561686.1|7739636_7740143_+|hypothetical-protein
MTRTYDRRDLIEVYLGSLEQGYGDYYSGATSYNAALKVYYVDLRDALERRFNSRLGVDGDTALRMLFHSTVASLLAIRTPWSGFVDAGLLNKRLEDAGENGERVNAASGRIAELTAQTREAHLEMLDALVVSFTGVRADLTVSEDDLRAEGVECTPPDTSGYDLFEDY

Crispr_ID: NC_022657_13

• CRISPR_ID: NC_022657_13
• CRISPR_location: 7923898-7924008
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NC_022657_13

Consensus_repeat	Method
CCCAACATCGGTGAAGTCGGGCCCTCG	CRISPRCasFinder

spacers of NC_022657_13

>13.1|7923925|57|NC_022657|CRISPRCasFinder
CGCCTCCGACCACACCCCAACATCGCTGAAGTTGGGCCCTCGGACCTCGAGCGACAG

CRISPR arrays and Neighbor proteins around NC_022657_13

CRISPR arrays

The CRISPR arrays of NC_022657_13

>merge|NC_022657|13|7923898-7924008|CRISPRCasFinder
CCCAACATCGGTGAAGTCGGGCCCTCGCGCCTCCGACCACACCCCAACATCGCTGAAGTTGGGCCCTCGGACCTCGAGCGACAGCCCAACATCGCTGAAGTCGGGCCCTCG

>NC_022657|13|10|7923898-7924008|CRISPRCasFinder
CCCAACATCGGTGAAGTCGGGCCCTCG	CGCCTCCGACCACACCCCAACATCGCTGAAGTTGGGCCCTCGGACCTCGAGCGACAG
CCCAACATCGCTGAAGTCGGGCCCTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023561836.1|7916211_7917159_-|30S-ribosomal-protein-S2	unknown	unknown	gnl|CDD|235396
NC_022657.1|WP_041841405.1|7918325_7918685_+|YraN-family-protein	unknown	unknown	gnl|CDD|237119
NC_022657.1|WP_023561851.1|7930112_7930559_-|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|240041
NC_022657.1|WP_084298496.1|7931247_7932150_-|signal-peptidase-I	unknown	unknown	gnl|CDD|274044
NC_022657.1|WP_023561841.1|7921382_7921568_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_041841406.1|7918685_7920218_+|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl|CDD|223679
NC_022657.1|WP_023561835.1|7915306_7916137_-|elongation-factor-Ts	unknown	unknown	gnl|CDD|236491
NC_022657.1|WP_041841408.1|7926235_7927165_+|tyrosine-recombinase-XerC	unknown	unknown	gnl|CDD|234698
NC_022657.1|WP_023561834.1|7914439_7915204_-|UMP-kinase	unknown	unknown	gnl|CDD|234735
NC_022657.1|WP_023561847.1|7927201_7928389_+|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|223594
NC_022657.1|WP_023561849.1|7928971_7929298_-|DUF2469-domain-containing-protein	unknown	unknown	gnl|CDD|313765
NC_022657.1|WP_084298253.1|7928397_7928997_-|M23-family-metallopeptidase	unknown	unknown	gnl|CDD|366703
NC_022657.1|WP_023561837.1|7917475_7918180_-|hypothetical-protein	unknown	unknown	gnl|CDD|165527
NC_022657.1|WP_023561840.1|7920201_7921377_+|DNA-protecting-protein-DprA	unknown	unknown	gnl|CDD|376794
NC_022657.1|WP_052359550.1|7922649_7922934_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561844.1|7924157_7924940_+|IS5/IS1182-family-transposase	unknown	unknown	gnl|CDD|372577
NC_022657.1|WP_023561850.1|7929294_7930113_-|ribonuclease-HII	unknown	unknown	gnl|CDD|234574
NC_022657.1|WP_023561845.1|7925759_7926215_-|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_023561852.1|7930600_7931251_-|signal-peptidase-I	unknown	unknown	gnl|CDD|274044
NC_022657.1|WP_023561843.1|7923147_7923552_+|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|153418

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023561836.1|7916211_7917159_-|30S-ribosomal-protein-S2	gnl|CDD|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	3.00217e-160
NC_022657.1|WP_084298253.1|7928397_7928997_-|M23-family-metallopeptidase	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.41434e-19
NC_022657.1|WP_023561837.1|7917475_7918180_-|hypothetical-protein	gnl|CDD|165527	PHA03269, PHA03269, envelope glycoprotein C; Provisional.	0.00085006
NC_022657.1|WP_084298496.1|7931247_7932150_-|signal-peptidase-I	gnl|CDD|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	2.13473e-43
NC_022657.1|WP_041841406.1|7918685_7920218_+|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl|CDD|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NC_022657.1|WP_023561850.1|7929294_7930113_-|ribonuclease-HII	gnl|CDD|234574	PRK00015, rnhB, ribonuclease HII; Validated.	1.60861e-90
NC_022657.1|WP_023561835.1|7915306_7916137_-|elongation-factor-Ts	gnl|CDD|236491	PRK09377, tsf, elongation factor Ts; Provisional.	1.07075e-123
NC_022657.1|WP_041841408.1|7926235_7927165_+|tyrosine-recombinase-XerC	gnl|CDD|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	4.6188e-126
NC_022657.1|WP_023561834.1|7914439_7915204_-|UMP-kinase	gnl|CDD|234735	PRK00358, pyrH, uridylate kinase; Provisional.	2.93539e-127
NC_022657.1|WP_023561849.1|7928971_7929298_-|DUF2469-domain-containing-protein	gnl|CDD|313765	pfam10611, DUF2469, Protein of unknown function (DUF2469). Member proteins often found in Actinomycetes clustered with signal peptidase and/or RNAse-HII.	5.31392e-63
NC_022657.1|WP_041841405.1|7918325_7918685_+|YraN-family-protein	gnl|CDD|237119	PRK12497, PRK12497, YraN family protein.	4.16867e-45
NC_022657.1|WP_023561840.1|7920201_7921377_+|DNA-protecting-protein-DprA	gnl|CDD|376794	pfam02481, DNA_processg_A, DNA recombination-mediator protein A. The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyze the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation.	5.08728e-75
NC_022657.1|WP_023561847.1|7927201_7928389_+|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl|CDD|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	1.07158e-38
NC_022657.1|WP_023561844.1|7924157_7924940_+|IS5/IS1182-family-transposase	gnl|CDD|372577	pfam13359, DDE_Tnp_4, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	3.22886e-29
NC_022657.1|WP_023561851.1|7930112_7930559_-|NUDIX-domain-containing-protein	gnl|CDD|240041	cd04685, Nudix_Hydrolase_26, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	5.47238e-42
NC_022657.1|WP_023561852.1|7930600_7931251_-|signal-peptidase-I	gnl|CDD|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.31776e-40
NC_022657.1|WP_023561843.1|7923147_7923552_+|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|153418	cd07377, WHTH_GntR, Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators. This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.	1.02651e-22

Protein sequences

>NC_022657.1|WP_023561843.1|7923147_7923552_+|winged-helix-turn-helix-transcriptional-regulator
MIDPSADRAVFRQLADLLRDQITSGDLAPGEPLPSELRLAQEYAISRTTVRQAIGQLRTEGLVTVDRPRGTFVRVPEPTETITLPRGARAAARMPTDAERRHHRLPEGVPVLVITTSDGTTTVHPADRVQLTRP
>NC_022657.1|WP_052359550.1|7922649_7922934_+|hypothetical-protein
MVNPQHLGARPAWDCQACGQPWPCAPAKSEMLVEFRRYPSSLTIYMSSYMAEALNDLSAHGQTPPADLYDRFLAWVRPSLTGVTPVHEITDIQR
>NC_022657.1|WP_023561841.1|7921382_7921568_-|hypothetical-protein
MGAHEIRERLGGVSRQRAYQITSRADFPAPVADLAQGKVWSTDDVEAWMKVHRKEQDDTEG
>NC_022657.1|WP_023561840.1|7920201_7921377_+|DNA-protecting-protein-DprA
MTETPDPGTEADRLARVALTWLGEPGNRTVWQLVQAGGAEATLARLLRGDVPESALRTAVISRSAAGDPRRLAEIALRRTERLGARVVVPSDPEWPTTVDTLATLEVDGGGRINRDVRPPLCLWVRGGWPLDEAFARSVAVVGARAATNYGLHVTNDLAYGLAEREWTVVSGGAFGIDAAAHRAALSAGGLTVAVLACGVDRPYPMGNAAMFEQIADSGVLMSEWPPGSEPLRHRFLIRNRVIAAATAGTVLVEAAARSGAVQTMSRTIALNRRAMVVPGPVTSAMSVGCHELLRKYPETTLVTGLPHVLDEVGKIGEYLAEVPRGRERPHDSLDEESALVLEAVPRRGTAGPEELATKSGLGVRTVLRRLSLLEMAGLVVRRNDGVALVR
>NC_022657.1|WP_041841406.1|7918685_7920218_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MSYARVLCVGLVGVEGHLIEVEADLSPGLPAVVLTGLPDTALHEARDRVRAAVVNSGQTWPNRRITVNLLPATLPKHGSAFDLAIAAALLAGAGELPAAPLEGVVVLGELGLDGAVRPIRGVLPMVAAAVRAGMTRVIVPLGNAREATVVPGVTVRAVDSLHRLVAYVRGEDRLLDPPPALPEPPVGGPDLADVAGQELGRYALEVAAAGGHHLAMLGPPGAGKTMLAERLPSVLPPLDDASALEVTALHSIAGVLPHDGRLVRRPPFQAPHHSASLAALVGGGSGLARPGALSLAHRGVLFLDEAPEFANAALQALRQPLESGRVLLARARGNTEYPARVQMVLAANPCPCANPAGDQFCECTALARRRYLGKLSGPLLDRIDIQIRIQPLSAAQLMTASAPAEGSPEVAVRVAAARSAAAARWSPGGWRVNAEVPGPQLRRPPFRLAARDTAVLRAGLDRGVLSARGFDRILRLAWSIADLDGRDRPTGTDVDEAAQLRMGEAHDRNS
>NC_022657.1|WP_041841405.1|7918325_7918685_+|YraN-family-protein
MTTERKAVGAYGERMAEEHLRAQGLVVLARNWRCADGEIDLILRDGDDVVFCEVKTRRGDRFGTPAEAIGPAKVRRLRRLAAHWLSESPVRPHEIRFDVVAVLPQRRGATVVEHVRAAF
>NC_022657.1|WP_023561837.1|7917475_7918180_-|hypothetical-protein
MEGHRRYAEEPEPSWYTGQRPSDPAAANAYDSGVYERPSGAFRLPEQRPADPYATPAGYSPPDPVTTSGSHALSSSDSGSIRMPVRGPEYPTVRPTSAAAADPPAVSTVTTTTTYGSGVTPESPPPAYNQPTSMVPMASAAPKRPVSALVFAVLTVVLLIPAVLLLVQATFVDDPASRGIVPAVLLTLGLPMTGLGLYTLAGIKTSGRDAWLRPPLVYLPIGLILLLAAGLGVA
>NC_022657.1|WP_023561836.1|7916211_7917159_-|30S-ribosomal-protein-S2
MAVVTMRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLRQTLEYIEKAYAYVRDTVAEGGHILFVGTKKQAQEAIAEHATRVGQPYVNHRWLGGMLTNFQTVYKRLQRMKELEAIGDLTGTAAGYTKKETLQLFREQTKLTKTLGGLRDMTKVPSAIWVVDTKKEHIAVDEARKLGIPVIAVLDTNCDPDEVDFPIPGNDDAIRSAELLTKVIAAAVADGLIKRSGRNRGSDDKPEPGTVAAGEPLPEWERDLYEGADKKAADAEPAAEPAAAPAAPAAAATPGNDATPVVDAVPDNPTAVAEPVAATAE
>NC_022657.1|WP_023561835.1|7915306_7916137_-|elongation-factor-Ts
MANYTAADVKKIRDLTGAGMMDCKKALDESDGDFDKAVEFLRIKGAKDVGKRAGRTAANGIVSHSGKALLELNCETDFVAKTPDFVALGQSLVELGEQNKLADAAALQAASFADGRTVADVVQDFSAKIGEKIVVNRFALLDGTVAVYLHRKAQDLPPQVGVLVEYTGKSDEAGDDDARAVGMQIAAMRPKFLTREEVPAETVESERRIAEETAREEGKPEQALSKIVEGRVNSFFKDYVLLEQPSVTDNKKTVKQVTADSGIQVTRFVRFEVGQE
>NC_022657.1|WP_023561834.1|7914439_7915204_-|UMP-kinase
MTMVTEQAVVVEEVPAHASERPRRVVLKLSGEVFGGGAVGVDPDVVQGIARQIATATRRGVQIAVVVGGGNFFRGAELQKRGMDRNRADYMGMLGTVMNCLALQDFLEKEGIETRVQTAITMAQVAEPYIPLRAIRHLEKGRVVIFGAGAGMPYFSTDTVTAQRALEIHADLVLMSKNGVDGVYTADPRTDPNARKIDHITFASVLQQGLRVADQAAFSLCEENGLPMLVFGAQGDDTIVRAVSGEKIGTLITI
>NC_022657.1|WP_023561844.1|7924157_7924940_+|IS5/IS1182-family-transposase
MLSYPATISLSSQSLNHLTTLIRHHRRQRRSRWRVLAPARQALLALAHLRNGDTYHRLATGFAISTSTAWRYVREAIDLLAATAPDLTTAMTRIRRLCFVILDGTLISIDRVADDKAYYSGKHRRHGMNIQVVADPAGRLIWASPGLPGRTHDLTAARTHGLIDALTTAGVITFADRAYQSVQRPFITPYKKHKGRKVFTAWNKKFNRDHAAIRANGERANATLKQWKILTQIRCSPGRTTPIVQAIQVLHSVETAQHPR
>NC_022657.1|WP_023561845.1|7925759_7926215_-|hypothetical-protein
MVSARVLLTSVLALSACSGPSTSPDPPTASAGFGNAPATSAAFTSPSGNIGCYVDRDGARCDIVKKSWKPPAKPSDCDLAWGSSISLNSSSQQPMFTCAGDTVLGADKILNYGETIQVGDLRCDSTSQRTRCEDTGTGHGFTLAIEQYTIF
>NC_022657.1|WP_041841408.1|7926235_7927165_+|tyrosine-recombinase-XerC
MIGDVSTREVHEALPVALREAVDDFGHHLASVDNRSAHTVRAYVGDVVSLLDHAAQVGCAAPADLDLGVVRGWLAQRMSDGAARTSQARRAAAARTFTAWAHRSGLAPADVGASLASPKAHRDLPSVLRADQAADLVVSTGDAHAVRDRAVLELLYATGVRVSELCGLDVADLDESRRVVRVFGKGAKERVVPYGIPAQKALDEWLRHGRAAVAIKGSGDALFLGARGGRLQQTVVRRIVAAAAQASGLPHTSPHDLRHSAATHLLDGGADLRAVQDLLGHASLSSTQIYTHVSTERLRAAFKQAHPRA
>NC_022657.1|WP_023561847.1|7927201_7928389_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MSVGDPPPAIPGARLLFSLDAATAYLNHGSFGAVPIGVQRAQQRLRDEIDRNPMSFFVHPGLTDRIVHTRRHLAAFLGADPDGSALVPNVTAAVSLVLQSVRLTSGDEVLLTDHGYGANAFAVRRQCRRDGATARTVALPLDATDAEVVSRIRNALRPGKTKLLVVDQITSPTAKVLPVREIAAAAREHDIPVLVDAAHVPGMLDVDVERIGADFWVGNLHKWAFAPRSTALLAVAPAWRRRIEPLIVSWEQESGFPMAVEFQGTIDYTPWLAAPAGLFTLRTLGLDTVRAHNAALAAYGQRVVGESLGLAPTDLPDPGAAEASMRILPLPSGLATTQPEAHALRQMVADKLATEVAINAWGGRGWLRLSAQVYNRPDEFENLAERLPPLLAGLR
>NC_022657.1|WP_084298253.1|7928397_7928997_-|M23-family-metallopeptidase
MRPASAAAELSTGRVAAVPGSEHDAGMHLLLPALLILLGAPALGLPSPGLPASASARPSAGVPLSAFRWPVAGAAVVRRFDPPPQPWLAGHRGVDLAAAPGVPVGASGAGTIVFAGTVAGRGVVSVAHPGGLRTTYEPVTAADLQPGDAVAAGDALGTLEAAHPGCPAAACLHWGLRRGTEYLDPLTLLGLGRVRLRPL
>NC_022657.1|WP_023561849.1|7928971_7929298_-|DUF2469-domain-containing-protein
MSAEDLEKYETEMELQLYREYRDIVRQFSYVVETERRFYLANQVDLHVRNSDGEVYFEVEMHDAWVWDMYRPARFVKNVRVMTFKDVNVEELEKPDISLPDEAGFGGS
>NC_022657.1|WP_023561850.1|7929294_7930113_-|ribonuclease-HII
MLSPPRTVVRREGGLYALERALQRRGFRHVAGADEAGRGACAGPLVAAAAILPEGKRGEIDELADSKLLTAAARERVYAEVVARALAWSVVIIPPAEVDGRGLHVCNLAAMRRALASLTTRPEYVLTDGFPVDGLGAPGLAVWKGDRVAACVAAASVLAKVTRDRLMVELDGRFPDYGFAVHKGYITDEHSAALTRHGPCAEHRFSYVNVAAVSGRGNRPPRARRPANLPADTAEPLMLWPAVEGTVGVASGEQPRPPVPVGEDEAMEGEKR
>NC_022657.1|WP_023561851.1|7930112_7930559_-|NUDIX-domain-containing-protein
MTFIDRRAARVLLIDAAERALLLRGSDPARPGERWWFTPGGGLAEGETPVQGAARELHEETGLKVEPSALGEPVFHEITEFSYNNRQYRQEQDFFLFRVPDWQVDTAGFDDDERRTITEHRWWSAPELDATTEQIFPLGLADLLRRVV
>NC_022657.1|WP_023561852.1|7930600_7931251_-|signal-peptidase-I
MIDEQAEEKRKGSFWRELPILLGVAILVAVLVRAFVLQTFYIPSPSMEHTLNVWDRVLVNKLVYDFRDPRRGEIVVFKAPTDWQSGTEGEDFIKRIIGVGGDHLVCCDDQERLIVNGHSLDEPYIYKDADGKQDPAADEKFDITVPAGRLWVMGDHRSASGDSLEHWEQTEDIQAATIESESIVGRAFTIFWPIGRATWLSVPKGFDGVPNAAPAN
>NC_022657.1|WP_084298496.1|7931247_7932150_-|signal-peptidase-I
MRSVEPMQGYRASSSGRRRGRVIRRKEMPLWQELPLLLVVAFCLAVLIRTFLVQAFYIPSGSMENTLAIKDRVLVNKVVYDMRDPLRGEIVVFRGTDNWAPEQPLDPVSNTFGAKLGRTIGDLVGVSRPGERDFIKRVIGLPGDKVACCDDQGRITVNGEPIDEPYIFENSPLEAPPNPRQCTSRRFAEVTIPAGEMFVMGDHRMVSQDARCQGPVPIDNIIGRAFVVVWPTKHFTSLSVPDNWKAYGEAHPVAAAPAGVYPAREPDPGTVAVMLPFLLSVGVSARSGLWLRLRRRRLRS

Crispr_ID: NC_022657_14

• CRISPR_ID: NC_022657_14
• CRISPR_location: 9328875-9329058
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_022657_14

Consensus_repeat	Method
GCCTCCTGGCAGCGCGACGCCGAG	PILER-CR

spacers of NC_022657_14

>14.1|9328899|60|NC_022657|PILER-CR
CCCGGCCGGCGAACCGACACCGGCTCCTGGCAACGCGAGCCCGACAACGGCGCAGCGCCG
>14.2|9328983|54|NC_022657|PILER-CR
AACGGTGCAGGCGCGGCGCCCTGGCAGCGGGGATCCGAGAACGGCGCGAGCTCA

CRISPR arrays and Neighbor proteins around NC_022657_14

CRISPR arrays

The CRISPR arrays of NC_022657_14

>merge|NC_022657|14|9328875-9329058|PILER-CR
CTCCTGGCAGCGCGACGCCGAGCCCGGCCGGCGAACCGACACCGGCTCCTGGCAACGCGAGCCCGACAACGGCGCAGCGCCGGCGTCCTGGCAGCGCGACGCCGAGAACGGTGCAGGCGCGGCGCCCTGGCAGCGGGGATCCGAGAACGGCGCGAGCTCAGCCCCCTGGCAGCGCGACGCCGAC

>NC_022657|14|2|9328875-9329058|PILER-CR
CTCCTGGCAGCGCGACGCCGAGCC	CGGCCGGCGAACCGACACCGGCTCCTGGCAACGCGAGCCCGACAACGGCGCAGCGCCGGC
GTCCTGGCAGCGCGACGCCGAGAA	CGGTGCAGGCGCGGCGCCCTGGCAGCGGGGATCCGAGAACGGCGCGAGCTCAGC
CCCCTGGCAGCGCGACGCCGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_022657.1|WP_023563148.1|9331269_9331719_-|50S-ribosomal-protein-L9	unknown	unknown	gnl|CDD|234659
NC_022657.1|WP_023563137.1|9313340_9314573_-|hypothetical-protein	unknown	unknown	gnl|CDD|379608
NC_022657.1|WP_023563145.1|9324339_9325080_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_148308357.1|9308757_9310974_+|EAL-domain-containing-protein	unknown	unknown	gnl|CDD|238923
NC_022657.1|WP_023563157.1|9343049_9343517_-|DUF5318-domain-containing-protein	unknown	unknown	gnl|CDD|379953
NC_022657.1|WP_023563152.1|9334373_9335150_+|deoxyribonuclease-IV	unknown	unknown	gnl|CDD|179214
NC_022657.1|WP_041843450.1|9315102_9315438_+|hypothetical-protein	unknown	unknown	unknown
NC_022657.1|WP_041841604.1|9312207_9312618_+|zf-TFIIB-domain-containing-protein	unknown	unknown	gnl|CDD|379195
NC_022657.1|WP_041841605.1|9314687_9315110_+|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl|CDD|376829
NC_022657.1|WP_023563136.1|9312657_9313332_+|maleylpyruvate-isomerase-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|371689
NC_022657.1|WP_023563149.1|9332011_9332578_-|single-stranded-DNA-binding-protein	unknown	unknown	gnl|CDD|236092
NC_022657.1|WP_041841609.1|9340007_9342860_-|transglycosylase-domain-containing-protein	unknown	unknown	gnl|CDD|223815
NC_022657.1|WP_007073789.1|9331733_9331973_-|30S-ribosomal-protein-S18	unknown	unknown	gnl|CDD|178997
NC_022657.1|WP_148308236.1|9333228_9334224_-|hypothetical-protein	unknown	unknown	gnl|CDD|237057
NC_022657.1|WP_023563155.1|9338332_9339877_-|DUF2029-domain-containing-protein	unknown	unknown	gnl|CDD|227937
NC_022657.1|WP_023563150.1|9332647_9332938_-|30S-ribosomal-protein-S6	unknown	unknown	gnl|CDD|179034
NC_022657.1|WP_023563146.1|9325076_9326519_-|replicative-DNA-helicase	unknown	unknown	gnl|CDD|273206
NC_022657.1|WP_041841608.1|9336038_9338213_+|hypothetical-protein	unknown	unknown	gnl|CDD|227904
NC_022657.1|WP_158510598.1|9318896_9324356_+|hypothetical-protein	unknown	unknown	gnl|CDD|373986
NC_022657.1|WP_052359933.1|9310946_9312206_+|DUF2029-domain-containing-protein	unknown	unknown	gnl|CDD|378217

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_022657.1|WP_023563148.1|9331269_9331719_-|50S-ribosomal-protein-L9	gnl|CDD|234659	PRK00137, rplI, 50S ribosomal protein L9; Reviewed.	4.5416e-66
NC_022657.1|WP_023563137.1|9313340_9314573_-|hypothetical-protein	gnl|CDD|379608	pfam14433, SUKH-3, SUKH-3 immunity protein. This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems.	1.07439e-41
NC_022657.1|WP_148308357.1|9308757_9310974_+|EAL-domain-containing-protein	gnl|CDD|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.14242e-91
NC_022657.1|WP_023563157.1|9343049_9343517_-|DUF5318-domain-containing-protein	gnl|CDD|379953	pfam17249, DUF5318, Family of unknown function (DUF5318). This family of unknown function is mostly found in Actinobacteria.	6.0138e-83
NC_022657.1|WP_041841608.1|9336038_9338213_+|hypothetical-protein	gnl|CDD|227904	COG5617, COG5617, Predicted integral membrane protein [Function unknown].	7.18969e-06
NC_022657.1|WP_023563149.1|9332011_9332578_-|single-stranded-DNA-binding-protein	gnl|CDD|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	2.34539e-93
NC_022657.1|WP_041841604.1|9312207_9312618_+|zf-TFIIB-domain-containing-protein	gnl|CDD|379195	pfam13453, zf-TFIIB, Transcription factor zinc-finger.	9.63006e-18
NC_022657.1|WP_041841605.1|9314687_9315110_+|YbaB/EbfC-family-nucleoid-associated-protein	gnl|CDD|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	1.97164e-12
NC_022657.1|WP_023563136.1|9312657_9313332_+|maleylpyruvate-isomerase-N-terminal-domain-containing-protein	gnl|CDD|371689	pfam11716, MDMPI_N, Mycothiol maleylpyruvate isomerase N-terminal domain.	1.75225e-05
NC_022657.1|WP_023563152.1|9334373_9335150_+|deoxyribonuclease-IV	gnl|CDD|179214	PRK01060, PRK01060, endonuclease IV; Provisional.	1.87264e-106
NC_022657.1|WP_007073789.1|9331733_9331973_-|30S-ribosomal-protein-S18	gnl|CDD|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	1.91184e-33
NC_022657.1|WP_148308236.1|9333228_9334224_-|hypothetical-protein	gnl|CDD|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	9.08489e-06
NC_022657.1|WP_023563155.1|9338332_9339877_-|DUF2029-domain-containing-protein	gnl|CDD|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	6.55003e-36
NC_022657.1|WP_023563150.1|9332647_9332938_-|30S-ribosomal-protein-S6	gnl|CDD|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	2.47193e-40
NC_022657.1|WP_023563146.1|9325076_9326519_-|replicative-DNA-helicase	gnl|CDD|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0
NC_022657.1|WP_041841609.1|9340007_9342860_-|transglycosylase-domain-containing-protein	gnl|CDD|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	5.22199e-111
NC_022657.1|WP_158510598.1|9318896_9324356_+|hypothetical-protein	gnl|CDD|373986	pfam15644, Gln_amidase, Papain fold toxin 1, glutamine deamidase. A papain fold toxin domain found in bacterial polymorphic toxin systems. In these systems they might function either as a releasing peptidase or toxin. In Shigella flexneri, UniProtKB:Q8VSD5, this protein is expressed from a plasmid, and delivered into the host via the type III secretion system where it deamidates the glutamine residue at position 100 in ubiquitin-activating enzyme E2, UBC13, to a glutamic acid residue. Invasion of host cells by pathogens normally invokes an acute inflammatory response through activating the TRAF6-mediated signalling pathway. UBC13 helps to activate TRAF6. Thus deamidation of UBC13 results in the dampening of the inflammatory response. The key glutaminase deamidase activity is mediated by a cys-his-glu triad, present in all members of the family.	2.04771e-30
NC_022657.1|WP_052359933.1|9310946_9312206_+|DUF2029-domain-containing-protein	gnl|CDD|378217	pfam09594, GT87, Glycosyltransferase family 87. The enzymes in this family are glycosyltransferases. PimE is involved in phosphatidylinositol mannoside (PIM) synthesis, a major class of glycolipids in all mycobacteria. PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of PIM. The family also includes alpha(1-->3) arabinofuranosyltransferase, invloved in the synthesis of of mycobacterial arabinogalactan.	0.00025947

Protein sequences

>NC_022657.1|WP_023563146.1|9325076_9326519_-|replicative-DNA-helicase
MSITDDARPESRPQSPPGGKGPGGRPPGGGGPPPQTGGFDKSPPQDIAAEQSVLGGMLLSKDAIADVVEILKSHDFYRPMHATVFDTILELYGRGEPADGVTVAAALSDSGDLQRIGGVPYLHTLIESVPTAANASYYARIVSERAVLRRLVEAGTKITQLGYGTGGNGGMDVDDIVDLAQQAVYDVTERRVSEDFAILADMLQPTLDEIEAVGATNGMMTGVPTGFSDLDRLLNGLHAGQLIIVAGRPGLGKSTASMDFARNAAIRANCASAIFSLEMSKIEIVMRLLSAEARVPLHILRSGQLSDDDWTKLARRMGEISEAPIFVDDTPSMNLMEIRAKARRLKQRHNLKLIVVDYLQLMSSPKKTESRQQEVAELSRGLKLLAKEVECPVIAVSQLNRGPEQRTDKRPQLSDLRESGSIEQDADVVILLHRDDYYDKESPRAGEADFIVAKHRNGPTDTVTVAAQLHLSRFVDMAIV
>NC_022657.1|WP_023563145.1|9324339_9325080_+|hypothetical-protein
MVMGGKGSRSSVYVYEYGEAYDDLRTAFFIDERDYNDPELAESALESAEAAMTRAGVIYEVEVTSGIHATRPIGVPTWEAFKQRHFVDGVPLPVRPMQQQLTIPPSWHAMVEAVDTAYHMFRAELMELLAEAMPSGQIAVTWDRGPLRRSPGSVDWSEEKFGFEIRLKAGLVDTSPAEALNSVGTALARRGWALKEPDPEQAEYQASQNLFTVSIRADQTTLMLFGESPLYWSPAEAGSSYVVEAR
>NC_022657.1|WP_158510598.1|9318896_9324356_+|hypothetical-protein
MDDYLRNVRDLRIAYANARRQDAIEAFEGKAESARRRVRSSRRSARVARFLKFDAGLAAFFEANVDLATADAERAESHVAALRDPNWTPPPGSLTEIAPHEWHRTNTDRGHLAPGAISVGNRSMLTGSDHPPSIDGTRQYGSWGGLRAPLAQHQLELENAMPRDANGDPARLADPRSPYFQLLNDGGSTADPTRGINCQDCVLSFFDTYMHGRPRVSAPRTFDAYGVANPQNPLYGEDLGSERVEHATGGRFQSLCPMVDGEDPAAAKQKVDQALTDVSAQLLAGGHGSFAFLVNAWESGAAHAWAAVNQNGQILFVDPQSGVVTESMPPYKHEGRSNGANMVALDALVVDGHGNPMPFLNRPDGLWHPQQTTLAPPPPRPTPIYYSSAYQSTDSAAPTDQPVLAEHPDPDPLPEPAPRPDPTPPTPEPVQPAPPPQPIPSPRRPVDRIAEAFEPKPAPDRIADALASSPDSSSPPKRPEQPSQSALERRSYSEYLERARTTHEQNRRDEYADYLIQTADTYRAKAVELNRQADAALAIGATVEGDHLRAEARLTSTDATDLETKADRVRAGELAPERVDVEPADWIRINNDVGTLASGAVETGDQSALTGNDIPPPIDQSRPYGKRGGLRAPLAVHQLDLEKAMPREADGKVQRLADPRSGEWFGLANDGGPTADPTRGINCVDGVLSLFDTYIHGRPRVSAPRTFDSYAQGNPTRPMGAEDQGLARIETTVQGEFQGLCPYVGGLDPQQAKQAVDTAMTNLQNHLYNAGHGAFAFIVTDSEQGTAHAWAAVNQNGTILFLDPQTGRLSESTPLYSHQGTPNNGNVVSMDAVVVNSHGEPAPLPYHQAGLWSRSSLQPLSAAGHEPTHDGRSESDSRLPTNEPDLVSADGLEVGAGEQVDPPTTEERATDTNGGSQQDQADLPQRIPSRAIELVDRLRSEDLRAEEQQVLESLTRAQQQTLIKAVADARSTAELELIRMRDLASSLPTFEDEERPALVDDQYRVKSVESLARKYQDRATTKKLSFERFLDESNDRVRFSIVVPERGYVETIQEALHSLRRDGYQILDILSFWNDGKGRHNGLNVTMKNSSGFTMELQFPTARSRKLGKDTHHLYEVVRLPSRSAKERVEAFFAILALSKYARMNLHQPPGVDQIEGLVTINTSFGRWTSQNTSLWLHFSEVLNQENRSLAQELNSWTLDVSDLTEMERLNAGDERADISLSGVPGGEGVTRSDQPHRVLDAPPGAAESGGLARDQGGMDLRSSDSGETSVQRRVRGRVDGGRSDDSRIDGPTVPPVGAPESGEAHGDERRGHQDGLGLRPATARVDSGSTIQPDAGPSGDLVAPNKSANDLPSRAIEEETLGGTRSDIGDGPGEDRLSAGPQGRPVGRNHEPDRLPGPAGQAVPSSVVERPADSMDLRSGSRGADALRRQVPGSNPSDRPRESREDLPRKPEHGAALGGDPAEHVRRGREDGLELRPTPPVTPAAETESRGSIDPVELAAAQEGVRVSVAPHSAELADVVVRLLEDHQANDHRLNLTEALVDADRRPRALELLVEVARRAVITEFGTLEQFLSGHPGVGDLFEPVEHQVNTTPDGLSRKKAFEAEARRRDPVRGVGPAPTLAELTLLDDYGIRLRRRVLPAATLEVEELASQLGGDALVSGRSKRSGDLLDKVRRMTSERPNRPARLDYRVGDVIDAVGLRLTVPDMDTLSAALELVKTHFGDRILEIENMYAQPKAQAPSYRVIPVIISIETDGLPCTYELQLTTQRASVAADIEHNTIYKPYVAVNGLQREAVEAAMEEAAALDQLETIERDGHGR
>NC_022657.1|WP_041843450.1|9315102_9315438_+|hypothetical-protein
MPEPELWLDLDRVAGGGRDLAAAGKHLTRQRTGPGAEVAALSAAPPWGTDDIGQTFENNYRPIEQQVLQAWEKLGLYVEGLGDAVVEAVQEATQTDHHSAVRVERTYGKRS
>NC_022657.1|WP_041841605.1|9314687_9315110_+|YbaB/EbfC-family-nucleoid-associated-protein
MADMADRDANHALRARFDDVYGQYNRLRSGMDDVQRRLAELRASADSDDGLIRATVGPRGQLLDLRLDRRIYRDMDAAELSRKIVTTVEQATAKATQQVEQLMADYLPADSGPMQFLKDNNFGSLLRRQDKIMREAGGDA
>NC_022657.1|WP_023563137.1|9313340_9314573_-|hypothetical-protein
MITREDAEEIAASWARGESEVRGYECQPMISEFDLGFVVWTKQPPAVLPIPGDGARTVIDRETGALSTYPGVPAEVIAEMYRTHQPSVAARRRTVDPQVELRRNAKRRASPTTAAHLTVDGHLFIARGAKGDQEINHHPLVAAYLSSLEPARTVRGTDRHAELIVLSDVLHEADRQRDVAITLDEARAWLRTADFESFFVRDQGDPLGGTSARPCESCILTLVDFAVLPWSQLAFTEPFVPYSDNIAQPGRFPDHVAGALADAGWRPMQQVVAEVLADGMIEDVVNVPGKRFQHRVFPAAREAVMAFPGIFCGLRGPGVRRWVRWLNLEPAAAAHSADALGELAAVIGAPLFPIGVEAKGDTIVAIDERGRIFALDQGGEWFLGNTLDEGLLSLLTGDGPAERLRDDGTW
>NC_022657.1|WP_023563136.1|9312657_9313332_+|maleylpyruvate-isomerase-N-terminal-domain-containing-protein
MRLPDVATALEAAYTGLTDVVADLDDLELLLPSGCRGWTICDLLLHVSLDAQRALVAFAVPVDGPADVDFVSYWRSFAGVGDASAASAHAQWVRRTAAAFNQPSGVVQRWTETSAAAVSVAHRADPGSFIGTQEHVLAVPDFTATLVTEAVIHHLDLIVSLPDAPEPPPEAIEIALSTLDGLAAPVGLPAHWSEHETLLKGTGREELTAADRSAVEGLTFPLLG
>NC_022657.1|WP_041841604.1|9312207_9312618_+|zf-TFIIB-domain-containing-protein
MQMTCPKCHGEMRVYERSGVTVDQCTECRGIFLDRGELERLFEAEANFNSRQASSAPRPAQAPQPGGYAAPPPPPPHGGGYASPPPPGYGQPAYPAAPYGAPQPQYGAGHHGHYRQGHHGHYRGRKKKSFLNELFD
>NC_022657.1|WP_052359933.1|9310946_9312206_+|DUF2029-domain-containing-protein
MFSATLARVTLLARLDRARDGLAADAALYALAAIFALVTALTSTLLPHRAWGAWAAWAYLGAFLIVVVQLVLRRPRWRMALTWVTWGGTTILPLIVQSVQRAGGRTDRAQEEVLVVEHMGERLASTGTPYLGPDAIAALPPGEQLLGYAPYQPGMAVFGLPRAAFGDVWWTDSRVWFAVVTAAALIVAARMLTQPVRAVQFATVLPICALTLATGGDDLPVLALALLALACCATDRFGAAGLAVGAAAALKLFAFPIVAVLAVLAIVTGNARRFLPGALGLPVLALLPAFMVDGDAFVENVIRFPLGHGLVTSPAQSPFPGYLISQWIPGGRIVAAALLVAVALAIAVLLTRRPPRTAASAALFCGYGLLAAILLMPTTRFGYLLYPLALLVWAPALSQALSRPTGTTAPRSDAALYRL
>NC_022657.1|WP_148308357.1|9308757_9310974_+|EAL-domain-containing-protein
MFVRDPMKIVFNVAKDTAAATAAVATAYAIGVRPTAALTLEVDDLPLLALGLTLAAVAYAVVDDLLGHTVVAMATRTSWRQSFSRNWDVVATVRLANVGLALLVALVIDLEQLLIVAMIPAVLALQFATKNRIRQRADQEAWQRLASSTDRLNVTELTSVLTAAVTRAPELFSADEAEIELSDTDPPRLIRGSAGGLVYEGRLATAPLRDSPAIEAQLAGPDTEAVGTLRLRFRKPVKLSDSERYKLQTFASSLYTAIRNARAYAELKRINAENAYAAAHDPLTGLANRRELLEQAAEVFKARAADGLCAMLLIDLNHFKEVNDTLGHGAGDQVLREVAKRLEDSAQPGDLVARLGGDEFAVLFTGLPTPAVAAHRAETMLADLERNIEVDGMQLTVEAAGGIAMAPASGGVQELMRRADVAMYQAKRSGQRTATYLHARDTADIGRLMLGGQLSRAVAEHEFVVDFQPIVDLGSGEVVSAEALARWHHPEHGSLSPMQFLETVERSGQLPAFADAVLEQSLTAYGMWREAGFDLPVAVNVSPRSLLDATFPNAVLARLAAHGVKADRLVLELAETLTLSQLEVVDRALSELRDAGVRLALDDFGTGVSSLSVLSRLPVHQLKIDREFVTAVETSSEAAAVIRSTVDLARSLHLTVIAEGVESEPQRHALWELGCVAGQGHLFSRPMRSGRMLAALQRGSGGRPGALASALHTAGSVVRMPHRRSPGHGRSSLPHLPA
>NC_022657.1|WP_023563148.1|9331269_9331719_-|50S-ribosomal-protein-L9
MKIILTQEVSGLGTPGDIVEVKNGYGRNYLLPQGFAIQWTKGAEKQVTVIKRARDAREIRDLGQANEVKGQLEGLKVTLTARSGTGGRLFGSITPAEIVDAVKTAGGPVLDRRRLELPTTIKTTGAYKVQVKLHPEVTASFPVNVVAAK
>NC_022657.1|WP_007073789.1|9331733_9331973_-|30S-ribosomal-protein-S18
MAKAAALRKPKKKVNPLDKDGITYIDYKDTALLRKFISDRGKIRARRVTGVTSQQQRQIARAVKNAREMALLPYTATAR
>NC_022657.1|WP_023563149.1|9332011_9332578_-|single-stranded-DNA-binding-protein
MAGETTITVVGNLTDDPELRFTPSGAAVAKFRIASTPRTMDKQSGEWKDGEPLFLACNVWRDAAEHVAESLQRGARVIVQGRLRQRSYETREGEKRTVYELEVDEIGPSLRYATAKVQKMSRSGGGGGGGFGASGGGGGGNRQPSNGGGGGGGNNSNFDDPWATAAPASGARSGGASSNSSFDDEPPF
>NC_022657.1|WP_023563150.1|9332647_9332938_-|30S-ribosomal-protein-S6
MRHYELMVILDPSLEERTVAPSLDTYLNVIRTAGGSVEKLDVWGRRRLSFEINKKAEGIYAVVDLQATPEAVAELDRQLRLNESILRTKVIRPETR
>NC_022657.1|WP_148308236.1|9333228_9334224_-|hypothetical-protein
MSRQVRHRVTAVALGGFLLGAALLTTGTANADQLEGGARQVVFAGGGVLGLSCKSTPSVESMTVPADGTVRVVNRTGHGAKLLINGTSKGSIPDDGATEVVFRRGTTAVTLDPNCTIADQATPVLVTATPSLTAQPDPMPAPTDTAAAETPSAPSNTPATSDGSGSSLPDSVSPATQPQRPSTSVAGRPSEVRPQTSRVNSVAAQAATTAAQAMPHGGAAPRVKTKATTLRGTGAAVAPAFSGMPPGDEKTILPGVPSLELTPPETQAAPVVPVVPPTDVVAAEPVAAVRPMPESQPIGLLALIAGVSVAGVAVAAIRAIVSQRASRASVA
>NC_022657.1|WP_023563152.1|9334373_9335150_+|deoxyribonuclease-IV
MRIGAHVDPAEPLDAAAARGADAVQFFLADPQGWKSPAARPDAEALKTSDVDVYIHAPYVINVATLNNRIRIPSRKLLLAHARAAAAVGAKGLIVHGGHVNAGDDIAVGFDNWRKTFAYAEKEGGLPLPILIENTAGGDHAIARRFDNLKRLWDAVGEFGAGFCLDTCHAHAGGEELLDIVDRVKSITGRIDLIHANDSKDTFDSGRDRHDNLGNGKIDPELVVAAIRAADAPAIVETPGGVEGQTADIALLREKAGS
>NC_022657.1|WP_041841608.1|9336038_9338213_+|hypothetical-protein
MDPKTSAASSTNPKTGPPTSADPKAGAAIGEDPKAGTATSTDPKAVTATSAGSKVAAAASADPKSGTASTTDPKAAAAAGADLKAGAAGPKAGDPAGAKADPATPGEKNGEDKKATPPGRRRKSKLPSTRPPGAPPDPWTAFAETSERAPGRIRRATRATGRGLIHEYALVVYGSLLLAVLLTWPTLRYPLHTFPQDNWDPSRQAWQVSWAGHILITDPARLWQSNAFFPEAYSFAFGNSLLGYAPAGMIGEGPLAAVLRYNILFVLAHALLAIGGYALIRQLGAGRTGALVGAVAFAYAPWRLAQEGHLDIISAGGIPLALAMLARGHGWSMRYGFRPDRRHAGWAATGWIIATWQVSLGFSLGLPFAYVLGAIFVVVAAAVLVRRLRRRSPRPVLGWRLLVTDGLGLLIFAGVGAMIALPYLRVPDTGPAGTEIKFFSPPLRSLLIGPAESRIWGAPHAVPRESLGWPAEMALLPGFVLYAFALVGLVFSVWRIWQRLILLAAVILGVLLTLGTTFFDGRWTYLPLFGHLPASFGVRIPGRLMVWVTLLLAILAAGAVAEFVRRAEHLAAHRMPPWPGPWLRLATLIPLLLVLVETWNATAHPVVPDQPASMRTVTGPMLVLPTAGLTDQTVMLWSTSRFQQVANGSGGFAPQRQSELRRSVAAFPDAASVQYLRALGITTVLLLRSEVTGTPWERAGDVPVDALGIRREDLDDNSVVFRLN
>NC_022657.1|WP_023563155.1|9338332_9339877_-|DUF2029-domain-containing-protein
MSAPSSPEADRPDLPAESDGFVRGLSQAIGGPLGDHAVRPGPRPGRFWNAQRIILALVCMTLALSWVQKSPCQDGDWQKNVQYTRFCYTDVLALYYAEGLNEGKVPYKDHPVEYPVVTGYFMGALGLPVHALGEKYPDINQGKWFYNINALVLSILAVASAAMMLALRRRRPWDVAIFALSPILLVTATVNWDFLAIGLALFGLYAWARRWPILAGFLLGLGGAAKLWPLFILGPLLVLGLRSKRVPQFLLATGAAIVAWLAVNLPVAILYRDSWDRFFNLNRERPIDWGTSWYIGRYLDSKWNTGVAGDQGPFQWLSDHVPVLNNISYALTFLACAAIGVLCLLAPRRPRLSQVAFLVVAAFLIFSKVWSQQYVLWLLPLIVLARPRWGAIIAWSVAEIGYFTAFYAELLGAGGKPVIPEGTFVLASSLRLITVAILCGLVIREIWRPELDPVRQTYADDPDGGVFDGAPDAGWLSSLRQRLRLEPRPAAVESASESAPPPPPPPPPTPAPVG
>NC_022657.1|WP_041841609.1|9340007_9342860_-|transglycosylase-domain-containing-protein
MNSYGDPQSARARARVPGPSAASTPDDDQSGYDDRQAPDAYRRPAGGRASVGGSVPRGAASVGAAPVGGRASVGAGRASVGAGTGSVGSARVGGRASVGGPEAGPAYGGGGRAAVARAAVRPVSPAVGGPDGPEGPEHGKRGSAGKILNKSAKRRRRTNILTAAAAVLVILLGGGVVGGTYFFDSVSFEEPAAESQTTQLLASDKKTVLASLGQFNRSIVPDASINPLIKLAVVSAEDKGFYKHNGIDMKGIARAAWNNFTGGDTQGASTITQQYAKYATKRKEITYNVKLREAVIARKMEDEYSKDQILGRYLNSVYFGRGAYGIEAAVKAYFGPSRSALTPPGQKGAITAGEAAILASVIKQPEPTATHRGYDPQKSLPDATERWNYTVGNMRELGLPAGNADAGVPAGIAPPTAYPTSWKKFNPEKCLTCNNNTPSAKIVKYVKRELRDMGITDARQNQGGLQILTTIDPKVQEAAEKAANRAKKSSPLHDMAETYKSALVSIDPDNGRVLAYYGGPDAASWDYAGPNYDDTGQKFLGGGRPPGSTFKIYTLIAALSAGYGMDTIWDSTLKKVDGGGKISNSGREGGSLQCPEKACDLETSVEQSYNFTFYWLADALGPEKVIEQAHKAGIQLIGDPETTARYDLNKLSESDLKEKNYGREVGFGQYAITALDHASGVATIANNGVYNKAHFVQRVSERDPKTGKFTAIKGKGEKLKGVEAFTPDVAAAVQNVMQKIPGINGISLDNGRKAIGKTGTWEFTGKGGKSGDNGDAWMVGGTKHLATSVWVGREKVNKKTKQMDLLPIYKPGGKPMNGGSVPGQIWKQFMDAASKAIDAKNDDFLPNSTAFVDPSKQGNGVKPPPPPPEPENPACQGIPLLCQDNGGNGNGDNGGNGNGGNGNGNGNGNGDNGQEQGTPGTFPTFPGGDAGNDTGTGGGENDGDNADDGG
>NC_022657.1|WP_023563157.1|9343049_9343517_-|DUF5318-domain-containing-protein
MRTQRQVVDYSLQKRAVLRDVHNGKVGTLEVCDASPYLKNAARFHGEPTDDRCPVCRRDNLTLVHYIYGDELKQSAGQARKLAELPVLAMTLREFQVFVVEVCQSCAWNHLIEQYLLGRDALNADELDQGGAVASSASGRHRETGSSSQRREGRQ

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022657_4	4.4|379399|18|NC_022657|CRT	379399-379416	18	NC_022657.1	5819494-5819511	1	0.944
NC_022657_4	4.4|379399|18|NC_022657|CRT	379399-379416	18	NC_022657.1	6373643-6373660	1	0.944
NC_022657_4	4.6|379477|18|NC_022657|CRT	379477-379494	18	NC_022657.1	5819494-5819511	1	0.944
NC_022657_4	4.6|379477|18|NC_022657|CRT	379477-379494	18	NC_022657.1	6373643-6373660	1	0.944
NC_022657_4	4.8|379555|18|NC_022657|CRT	379555-379572	18	NC_022657.1	5819494-5819511	1	0.944
NC_022657_4	4.8|379555|18|NC_022657|CRT	379555-379572	18	NC_022657.1	6373643-6373660	1	0.944
NC_022657_4	4.10|379633|18|NC_022657|CRT	379633-379650	18	NC_022657.1	5819494-5819511	1	0.944
NC_022657_4	4.10|379633|18|NC_022657|CRT	379633-379650	18	NC_022657.1	6373643-6373660	1	0.944
NC_022657_12	12.2|7729916|20|NC_022657|CRT	7729916-7729935	20	NC_022657.1	8850763-8850782	2	0.9

1. spacer 4.4|379399|18|NC_022657|CRT matches to position: 5819494-5819511, mismatch: 1, identity: 0.944

cgcggttcggcccagtcg	CRISPR spacer
cgcggttcggcccggtcg	Protospacer
*************.****

2. spacer 4.4|379399|18|NC_022657|CRT matches to position: 6373643-6373660, mismatch: 1, identity: 0.944

cgcggttcggcccagtcg	CRISPR spacer
cgcgggtcggcccagtcg	Protospacer
***** ************

3. spacer 4.6|379477|18|NC_022657|CRT matches to position: 5819494-5819511, mismatch: 1, identity: 0.944

cgcggttcggcccagtcg	CRISPR spacer
cgcggttcggcccggtcg	Protospacer
*************.****

4. spacer 4.6|379477|18|NC_022657|CRT matches to position: 6373643-6373660, mismatch: 1, identity: 0.944

cgcggttcggcccagtcg	CRISPR spacer
cgcgggtcggcccagtcg	Protospacer
***** ************

5. spacer 4.8|379555|18|NC_022657|CRT matches to position: 5819494-5819511, mismatch: 1, identity: 0.944

cgcggttcggcccagtcg	CRISPR spacer
cgcggttcggcccggtcg	Protospacer
*************.****

6. spacer 4.8|379555|18|NC_022657|CRT matches to position: 6373643-6373660, mismatch: 1, identity: 0.944

cgcggttcggcccagtcg	CRISPR spacer
cgcgggtcggcccagtcg	Protospacer
***** ************

7. spacer 4.10|379633|18|NC_022657|CRT matches to position: 5819494-5819511, mismatch: 1, identity: 0.944

cgcggttcggcccagtcg	CRISPR spacer
cgcggttcggcccggtcg	Protospacer
*************.****

8. spacer 4.10|379633|18|NC_022657|CRT matches to position: 6373643-6373660, mismatch: 1, identity: 0.944

cgcggttcggcccagtcg	CRISPR spacer
cgcgggtcggcccagtcg	Protospacer
***** ************

9. spacer 12.2|7729916|20|NC_022657|CRT matches to position: 8850763-8850782, mismatch: 2, identity: 0.9

ttcaaggcgtccacgagcgg	CRISPR spacer
ttcacggcgtcctcgagcgg	Protospacer
**** ******* *******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022657_4	4.1|379273|24|NC_022657|CRT	379273-379296	24	NC_010510	Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence	228960-228983	2	0.917
NC_022657_4	4.2|379315|24|NC_022657|CRT	379315-379338	24	NC_008010	Deinococcus geothermalis DSM 11300 plasmid pDGEO01, complete sequence	429649-429672	2	0.917
NC_022657_9	9.11|7131227|23|NC_022657|CRT	7131227-7131249	23	NZ_CP032520	Cupriavidus oxalaticus strain T2 plasmid unnamed1, complete sequence	428451-428473	2	0.913
NC_022657_4	4.2|379315|24|NC_022657|CRT	379315-379338	24	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	627484-627507	3	0.875
NC_022657_4	4.2|379315|24|NC_022657|CRT	379315-379338	24	MT310854	Streptomyces phage CricKo, complete genome	34791-34814	3	0.875
NC_022657_4	4.2|379315|24|NC_022657|CRT	379315-379338	24	MH155877	Streptomyces phage Rainydai, complete genome	34791-34814	3	0.875
NC_022657_4	4.2|379315|24|NC_022657|CRT	379315-379338	24	MT657340	Streptomyces phage Thiqqums, complete genome	34791-34814	3	0.875
NC_022657_4	4.2|379315|24|NC_022657|CRT	379315-379338	24	MH155880	Streptomyces phage SendItCS, complete genome	34104-34127	3	0.875
NC_022657_4	4.3|379357|24|NC_022657|CRT	379357-379380	24	NZ_CP023550	Rhodobacter sp. CZR27 plasmid unnamed2, complete sequence	102844-102867	3	0.875
NC_022657_4	4.3|379357|24|NC_022657|CRT	379357-379380	24	NZ_CP010826	Thermus aquaticus Y51MC23 plasmid pTA78, complete sequence	72816-72839	3	0.875
NC_022657_4	4.3|379357|24|NC_022657|CRT	379357-379380	24	NC_019331	Arthrobacter sp. J3-40 plasmid pJ340-114, complete sequence	93676-93699	3	0.875
NC_022657_4	4.5|379435|24|NC_022657|CRT	379435-379458	24	KU310944	Pseudomonas phage YMC11/06/C171_PPU_BP, complete genome	13058-13081	3	0.875
NC_022657_4	4.7|379513|24|NC_022657|CRT	379513-379536	24	LT559119	Nonomuraea sp. ATCC 39727 isolate nono1 genome assembly, plasmid: I	6979-7002	3	0.875
NC_022657_4	4.7|379513|24|NC_022657|CRT	379513-379536	24	NZ_LR134449	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 7, complete sequence	58848-58871	3	0.875
NC_022657_4	4.9|379591|24|NC_022657|CRT	379591-379614	24	LT559119	Nonomuraea sp. ATCC 39727 isolate nono1 genome assembly, plasmid: I	6979-7002	3	0.875
NC_022657_4	4.9|379591|24|NC_022657|CRT	379591-379614	24	NZ_LR134449	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 7, complete sequence	58848-58871	3	0.875
NC_022657_4	4.11|379669|24|NC_022657|CRT	379669-379692	24	NZ_LR134449	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 7, complete sequence	58848-58871	3	0.875
NC_022657_4	4.11|379669|24|NC_022657|CRT	379669-379692	24	LT559119	Nonomuraea sp. ATCC 39727 isolate nono1 genome assembly, plasmid: I	6979-7002	3	0.875
NC_022657_9	9.1|7130784|23|NC_022657|CRT	7130784-7130806	23	NZ_CP027301	Serratia marcescens strain SGAir0764 plasmid unnamed_1	61979-62001	3	0.87
NC_022657_3	3.1|249229|30|NC_022657|CRISPRCasFinder	249229-249258	30	NC_016624	Azospirillum lipoferum 4B plasmid AZO_p5, complete sequence	440601-440630	9	0.7
NC_022657_3	3.1|249229|30|NC_022657|CRISPRCasFinder	249229-249258	30	NZ_CP029834	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed4, complete sequence	376754-376783	9	0.7
NC_022657_3	3.1|249229|30|NC_022657|CRISPRCasFinder	249229-249258	30	NZ_CP054620	Azospirillum oryzae strain KACC 14407 plasmid unnamed5, complete sequence	241256-241285	9	0.7

1. spacer 4.1|379273|24|NC_022657|CRT matches to NC_010510 (Methylobacterium radiotolerans JCM 2831 plasmid pMRAD01, complete sequence) position: , mismatch: 2, identity: 0.917

tccggttcggctcccgctcagccg	CRISPR spacer
tccggcgcggctcccgctcagccg	Protospacer
*****. *****************

2. spacer 4.2|379315|24|NC_022657|CRT matches to NC_008010 (Deinococcus geothermalis DSM 11300 plasmid pDGEO01, complete sequence) position: , mismatch: 2, identity: 0.917

cctggttccggccccggtggcccc	CRISPR spacer
cccggttccgcccccggtggcccc	Protospacer
**.******* *************

3. spacer 9.11|7131227|23|NC_022657|CRT matches to NZ_CP032520 (Cupriavidus oxalaticus strain T2 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.913

ggaggcctgggtgggcccgatat	CRISPR spacer
ggcggcctgggtgggcccgagat	Protospacer
** ***************** **

4. spacer 4.2|379315|24|NC_022657|CRT matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 3, identity: 0.875

cctggttccggccccggtggcccc	CRISPR spacer
tctgctcccggccccggtggcccc	Protospacer
.*** *.*****************

5. spacer 4.2|379315|24|NC_022657|CRT matches to MT310854 (Streptomyces phage CricKo, complete genome) position: , mismatch: 3, identity: 0.875

cctggttccggccccggtggcccc	CRISPR spacer
gctggctccggccccgatggcccc	Protospacer
 ****.**********.*******

6. spacer 4.2|379315|24|NC_022657|CRT matches to MH155877 (Streptomyces phage Rainydai, complete genome) position: , mismatch: 3, identity: 0.875

cctggttccggccccggtggcccc	CRISPR spacer
gctggctccggccccgatggcccc	Protospacer
 ****.**********.*******

7. spacer 4.2|379315|24|NC_022657|CRT matches to MT657340 (Streptomyces phage Thiqqums, complete genome) position: , mismatch: 3, identity: 0.875

cctggttccggccccggtggcccc	CRISPR spacer
gctggctccggccccgatggcccc	Protospacer
 ****.**********.*******

8. spacer 4.2|379315|24|NC_022657|CRT matches to MH155880 (Streptomyces phage SendItCS, complete genome) position: , mismatch: 3, identity: 0.875

cctggttccggccccggtggcccc	CRISPR spacer
gctggctccggccccgatggcccc	Protospacer
 ****.**********.*******

9. spacer 4.3|379357|24|NC_022657|CRT matches to NZ_CP023550 (Rhodobacter sp. CZR27 plasmid unnamed2, complete sequence) position: , mismatch: 3, identity: 0.875

tccggtcccggccccgctcgtccc	CRISPR spacer
tccggtccaggtcccgctcgtcca	Protospacer
******** **.*********** 

10. spacer 4.3|379357|24|NC_022657|CRT matches to NZ_CP010826 (Thermus aquaticus Y51MC23 plasmid pTA78, complete sequence) position: , mismatch: 3, identity: 0.875

tccggtcccggccccgctcgtccc	CRISPR spacer
gccgctccctgccccgctcgtccc	Protospacer
 *** **** **************

11. spacer 4.3|379357|24|NC_022657|CRT matches to NC_019331 (Arthrobacter sp. J3-40 plasmid pJ340-114, complete sequence) position: , mismatch: 3, identity: 0.875

tccggtcccggccccgctcgtccc	CRISPR spacer
tccggtccaggccgcgctcgtcca	Protospacer
******** **** ********* 

12. spacer 4.5|379435|24|NC_022657|CRT matches to KU310944 (Pseudomonas phage YMC11/06/C171_PPU_BP, complete genome) position: , mismatch: 3, identity: 0.875

tccggctcgggttccgcgcagcct	CRISPR spacer
tccggctcgggtaccgcgcagctc	Protospacer
************ *********..

13. spacer 4.7|379513|24|NC_022657|CRT matches to LT559119 (Nonomuraea sp. ATCC 39727 isolate nono1 genome assembly, plasmid: I) position: , mismatch: 3, identity: 0.875

tccgggtcgggttccgcgcagcct	CRISPR spacer
tccgggtcgggttcggcgcagaca	Protospacer
************** ****** * 

14. spacer 4.7|379513|24|NC_022657|CRT matches to NZ_LR134449 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 7, complete sequence) position: , mismatch: 3, identity: 0.875

tccgggtcgggttccgcgcagcct	CRISPR spacer
tccgggtcgggttgcgcgccgccg	Protospacer
************* ***** *** 

15. spacer 4.9|379591|24|NC_022657|CRT matches to LT559119 (Nonomuraea sp. ATCC 39727 isolate nono1 genome assembly, plasmid: I) position: , mismatch: 3, identity: 0.875

tccgggtcgggttccgcgcagcct	CRISPR spacer
tccgggtcgggttcggcgcagaca	Protospacer
************** ****** * 

16. spacer 4.9|379591|24|NC_022657|CRT matches to NZ_LR134449 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 7, complete sequence) position: , mismatch: 3, identity: 0.875

tccgggtcgggttccgcgcagcct	CRISPR spacer
tccgggtcgggttgcgcgccgccg	Protospacer
************* ***** *** 

17. spacer 4.11|379669|24|NC_022657|CRT matches to NZ_LR134449 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 7, complete sequence) position: , mismatch: 3, identity: 0.875

tccgggtcgggttccgcgcagccc	CRISPR spacer
tccgggtcgggttgcgcgccgccg	Protospacer
************* ***** *** 

18. spacer 4.11|379669|24|NC_022657|CRT matches to LT559119 (Nonomuraea sp. ATCC 39727 isolate nono1 genome assembly, plasmid: I) position: , mismatch: 3, identity: 0.875

tccgggtcgggttccgcgcagccc	CRISPR spacer
tccgggtcgggttcggcgcagaca	Protospacer
************** ****** * 

19. spacer 9.1|7130784|23|NC_022657|CRT matches to NZ_CP027301 (Serratia marcescens strain SGAir0764 plasmid unnamed_1) position: , mismatch: 3, identity: 0.87

gcaagcccgcgctcgctcaacac	CRISPR spacer
gtaagcccgcgctcgctcaactt	Protospacer
*.******************* .

20. spacer 3.1|249229|30|NC_022657|CRISPRCasFinder matches to NC_016624 (Azospirillum lipoferum 4B plasmid AZO_p5, complete sequence) position: , mismatch: 9, identity: 0.7

tgtgatggctctgtaccaccagctgtccga	CRISPR spacer
cagcggggcgctgtaccaccagccgtccgg	Protospacer
..  . *** *************.*****.

21. spacer 3.1|249229|30|NC_022657|CRISPRCasFinder matches to NZ_CP029834 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed4, complete sequence) position: , mismatch: 9, identity: 0.7

tgtgatggctctgtaccaccagctgtccga	CRISPR spacer
cagcggggcgctgtaccaccagccgtccgg	Protospacer
..  . *** *************.*****.

22. spacer 3.1|249229|30|NC_022657|CRISPRCasFinder matches to NZ_CP054620 (Azospirillum oryzae strain KACC 14407 plasmid unnamed5, complete sequence) position: , mismatch: 9, identity: 0.7

tgtgatggctctgtaccaccagctgtccga	CRISPR spacer
caatggggcgctgtaccaccagccgtccgg	Protospacer
..  . *** *************.*****.