CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_022780	Pediococcus pentosaceus SL4, complete sequence	3 crisprs	cas9,cas1,cas2,csn2,cas3,DEDDh,WYL,DinG,csa3	1	6	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022780_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022780_1

480897-481526

TypeII

Consensus_repeat	Method
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	PILER-CR
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	CRISPRCasFinder
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	CRT

9 spacers

csn2,cas2,cas1,cas9,cas3

The CRISPR arrays of NC_022780_1

>merge|NC_022780|1|480897-481526|PILER-CR,CRISPRCasFinder,CRT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACATAATACAATAATAGTAAATTCCACTGTATGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACTGAAGCTGTTCAAAATGCGCATTATGGAGTGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACTAAAATTAGCATTACCAGTTGTCGCCATAAGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACTACGTTTGATATATCCTAACTCTGCAGCTTGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACTTCAATTGTCACTGCAGCAACAGGAGTGTGGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACAATAAAAAAACCTCCATCCGAAGACAGAGGGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACAAAAGAACAACTGAGTAGCCTCCCAGGGCTGTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTACTAAATTTCGTCATTAAGCTTCCTCCAGTTCGTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTACTGCGACCATCGCTATACATAAGCATATTTGGTTTCAGAAGAGTGTTAAATCAGTAAGCCTAAAATT

>NC_022780|1|1|480897-481460|PILER-CR
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	ATAATACAATAATAGTAAATTCCACTGTAT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TGAAGCTGTTCAAAATGCGCATTATGGAGT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TAAAATTAGCATTACCAGTTGTCGCCATAA
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TACGTTTGATATATCCTAACTCTGCAGCTT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TTCAATTGTCACTGCAGCAACAGGAGTGTG
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	AATAAAAAAACCTCCATCCGAAGACAGAGG
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	AAAAGAACAACTGAGTAGCCTCCCAGGGCT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TAAATTTCGTCATTAAGCTTCCTCCAGTTC
GTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTAC

>NC_022780|1|1|480897-481526|CRISPRCasFinder
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	ATAATACAATAATAGTAAATTCCACTGTAT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TGAAGCTGTTCAAAATGCGCATTATGGAGT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TAAAATTAGCATTACCAGTTGTCGCCATAA
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TACGTTTGATATATCCTAACTCTGCAGCTT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TTCAATTGTCACTGCAGCAACAGGAGTGTG
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	AATAAAAAAACCTCCATCCGAAGACAGAGG
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	AAAAGAACAACTGAGTAGCCTCCCAGGGCT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TAAATTTCGTCATTAAGCTTCCTCCAGTTC
GTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTAC	TGCGACCATCGCTATACATAAGCATATTTG
GTTTCAGAAGAGTGTTAAATCAGTAAGCCTAAAATT

>NC_022780|1|1|480897-481526|CRT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	ATAATACAATAATAGTAAATTCCACTGTAT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TGAAGCTGTTCAAAATGCGCATTATGGAGT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TAAAATTAGCATTACCAGTTGTCGCCATAA
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TACGTTTGATATATCCTAACTCTGCAGCTT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TTCAATTGTCACTGCAGCAACAGGAGTGTG
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	AATAAAAAAACCTCCATCCGAAGACAGAGG
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	AAAAGAACAACTGAGTAGCCTCCCAGGGCT
GTTTCAGAAGAGTGTTAAATCAATAAGTTCAAGTAC	TAAATTTCGTCATTAAGCTTCCTCCAGTTC
GTTTCAGAAGAATGTTAAATCAATAAGTTCAAGTAC	TGCGACCATCGCTATACATAAGCATATTTG
GTTTCAGAAGAGTGTTAAATCAGTAAGCCTAAAATT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022780.1\|WP_023440045.1\|488612_489932_+\|DEAD/DEAH-box-helicase-family-protein	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|226583
NC_022780.1\|WP_002834462.1\|491448_493809_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NC_022780.1\|WP_023440034.1\|468198_468513_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379262
NC_022780.1\|WP_023440040.1\|479007_479916_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NC_022780.1\|WP_023440039.1\|474759_478800_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	mkCas0193_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
NC_022780.1\|WP_023440033.1\|467643_468036_-\|hypothetical-protein	unknown	unknown	unknown
NC_022780.1\|WP_023440043.1\|481658_482309_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NC_022780.1\|WP_002834470.1\|482805_484425_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NC_022780.1\|WP_002834471.1\|482493_482778_+\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NC_022780.1\|WP_023440041.1\|479893_480199_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
NC_022780.1\|WP_023440047.1\|490733_491288_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NC_022780.1\|WP_023440042.1\|480195_480867_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
NC_022780.1\|WP_023440038.1\|473941_474568_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370635
NC_022780.1\|WP_023440036.1\|469909_471310_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_022780.1\|WP_023440037.1\|471358_473893_+\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341064
NC_022780.1\|WP_011673068.1\|486751_487912_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NC_022780.1\|WP_023440035.1\|469120_469777_+\|hypothetical-protein	unknown	unknown	unknown
NC_022780.1\|WP_023440046.1\|490171_490603_+\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NC_022780.1\|WP_023440044.1\|487926_488580_-\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|376491
NC_022780.1\|WP_002834469.1\|484768_486601_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|372624

Protein	Function_ID	Function_description	E-value
NC_022780.1\|WP_023440045.1\|488612_489932_+\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|226583	COG4098, comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair].	1.9192e-162
NC_022780.1\|WP_023440038.1\|473941_474568_-\|hypothetical-protein	gnl\|CDD\|370635	pfam09726, Macoilin, Macoilin family. The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.	4.3651e-05
NC_022780.1\|WP_023440040.1\|479007_479916_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	3.20317e-98
NC_022780.1\|WP_023440039.1\|474759_478800_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	1.83214e-138
NC_022780.1\|WP_002834462.1\|491448_493809_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NC_022780.1\|WP_023440043.1\|481658_482309_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	6.39146e-10
NC_022780.1\|WP_002834470.1\|482805_484425_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NC_022780.1\|WP_002834471.1\|482493_482778_+\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	1.22914e-44
NC_022780.1\|WP_023440041.1\|479893_480199_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.01836e-28
NC_022780.1\|WP_023440047.1\|490733_491288_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.65368e-37
NC_022780.1\|WP_023440042.1\|480195_480867_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	4.78551e-79
NC_022780.1\|WP_023440034.1\|468198_468513_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	8.84106e-08
NC_022780.1\|WP_023440036.1\|469909_471310_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.4214e-50
NC_022780.1\|WP_023440037.1\|471358_473893_+\|M1-family-metallopeptidase	gnl\|CDD\|341064	cd09601, M1_APN-Q_like, Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1). This M1 peptidase family includes eukaryotic and bacterial members: the catalytic domains of aminopeptidase N (APN), aminopeptidase Q (APQ, laeverin), endoplasmic reticulum aminopeptidase 1 (ERAP1) as well as tricorn interacting factor F3. Aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease, preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is considered a marker of differentiation since it is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. ERAP1, also known as endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP), adipocyte derived leucine aminopeptidase (A-LAP), or aminopeptidase regulating tumor necrosis factor receptor I (THFRI) shedding (ARTS-1), associates with the closely related ER aminopeptidase ERAP2, for the final trimming of peptides within the ER for presentation by MHC class I molecules. ERAP1 is associated with ankylosing spondylitis (AS), an inflammatory arthritis that predominantly affects the spine. ERAP1 also aids in the shedding of membrane-bound cytokine receptors. The tricorn interacting factor F3, together with factors F1 and F2, degrades the tricorn protease products, producing free amino acids, thus completing the proteasomal degradation pathway. F3 is homologous to F2, but not F1, and shows a strong preference for glutamate in the P1' position. APQ, also known as laeverin, is specifically expressed in human embryo-derived extravillous trophoblasts (EVTs) that invade the uterus during early placentation. It cleaves the N-terminal amino acid of various peptides such as angiotensin III, endokinin C, and kisspeptin-10, all expressed in the placenta in large quantities. APN is a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs are also putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	0
NC_022780.1\|WP_011673068.1\|486751_487912_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	1.04782e-84
NC_022780.1\|WP_023440046.1\|490171_490603_+\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	1.64527e-30
NC_022780.1\|WP_023440044.1\|487926_488580_-\|YigZ-family-protein	gnl\|CDD\|376491	pfam01205, UPF0029, Uncharacterized protein family UPF0029.	2.22012e-58
NC_022780.1\|WP_002834469.1\|484768_486601_+\|APC-family-permease	gnl\|CDD\|372624	pfam13520, AA_permease_2, Amino acid permease.	4.77235e-28

>NC_022780.1|WP_023440042.1|480195_480867_+|type-II-A-CRISPR-associated-protein-Csn2
MKITYKTHDNLEIKPGQISILGTNSPTVYTDIIQGLQDENEKISIVDENYNALEIAHAIDWIGDVGTQNLVLTKYLRQIEKLFLQSVTDEQQNKIHDEINRIFNIVSEQLFLLDLPIEVNFDFDLKKLFKYCGIRFDPILISKPYGIIETIIKIHETSNLDSCIVLTNVAHYLTSVEFEELSQLVKETNQKILLIEFTEIEEQNFYRNAEFYYIDTDFIDWHN
>NC_022780.1|WP_023440041.1|479893_480199_+|CRISPR-associated-endonuclease-Cas2
MRLMIMFDLPVETAKQRKQYRQFRKSLINEGFLMIQYSVYVRVCVTKKSATLMENRIKTFLPENGTIQALTLTEKQYNDMHFLVGDRVEDVRNNSDRTVIL
>NC_022780.1|WP_023440040.1|479007_479916_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRSIIITQHAKLAYSSRTMIVQTNDGINQIPIDDISLLLISTTQAVITTALISELSKKNVKIIFTDDTHKPISETYGCYPNHRSAELLREQLNWEIGRSQVLWTKVVASKLINQINVLKLQNVKTSSLEDELNKLELNDITNREAVIARKYFPLLFEDGFSRRNNGSVINTALNYGYSILLSTINQEIVSNGYLTYIGIHHDNEENQFNLASDLMEPFRPIVDFWLANKKFNEFTPDVKYGLVELLSLEIKYNGKNTLLRNAITVHVRNCLKYLSNEEQNIKIEMELLDEVPNHAINDNV
>NC_022780.1|WP_023440039.1|474759_478800_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MEKVPYNIGLDIGTSSIGFAATDNLNKPIRAKGKTVIGVRLFEEGKTAADRRGFRTTRRRLSRRKWRLRLLDEIFDKEMAKVDNTFFARLKESNLSPKDANKKYLGSLLFPEKKDFKFYEDYPTIYHLRYALMHEKRQFDIREVYLAMHHIIKYRGNFLNSAPMNSFKTQDFDFVAKFEKLNELFESIDAEHETKFDIENISKFRDIMLNQDIRKLDRKKQAAKILILDSTDKTAKKINNKIATAVANSALGYKFALDAILKLDVEESKDWSISLNDEEIDSILDNLTSDLDAERIEIIEILRDLYSHIALNEIVPNGQSLSKSMMDKYDKHHADLDVLKKVISNMDDRKKAKSLKNIYNQYVGKTNDKVLDKDEFYKQIQKNLDESEDAMKIVNEIELDQFMPKQRTSQNGVIPHQLHQKELDEIIENQKQYYPFLAEPNPNEKRKPHAQFKLDELIAFKIPYYVGPLITKEEQQAQSGAKFAWMKRKQDGVITPWNFDEKVDRMASANEFIRRMTTKDTYLLGEDVLPDESLIYQKFKVLNELNNVKVNDKKLTVSDKQDIFNDLFKKQKTVSVSKLQKYFVTEKHYLTEPTIKGLSDTKKFSNSLSTYIDFEKIFGNEILADQNKQNDLEKIIEWSTIFEDRKIFEDKLHEIEWLTEKQIKAVRRYRGWGRLSKKLLVDLRNNEGKSILDELWRTNDNFMQIQAREEFAKSIVEANQKLMNLGGAASVQNTVESTLEDAYTSPQNKKAIRQVIKVVEDIVKAVGYAPEKITIEFTRGADKNPRRTQNRQKQIMEVYKTAAKEIVDATLKGQLENEEKLTDKLYLYFTQLGKDIYSGETINIDQLNNYDIDHILPQAFIKDDSLDNRVLTSRDLNNGKSDSVPVKQFGANMKSFWMRLQAHGLISKRKLNNLMTDPDSIGKYTMQGFVRRQLVETSQVIKLTANILGAIYGENTDIVEIPAKLTHQMREKFNLYKVREVNDYHHAFDAYLTTFVGNYLFKRYPKLRPYFVYGDFKMTDNALKGMRRFNFLHDLKDDEVLVDNETGEVLWEGQKSIEELKKIYGYKFMLTTHEAYTQHGPMFKQTVYSSDTPGKLIKIKNNKPTEIYGGYTSNTDAYMAIVRIKARKGDTYKVVGVPRKEGDALSRIKLLDESKYHENLKNILAINLNKSLNKFDVVLDKVKYRQVIYDGTDHLMLGSSKYKYSTKQLVLSDQSMKILSSTGEFSDEELIKVFDEIMYIVNKNFSLYDTRGFRDKLNNARENFIKLPNKTLFEKGKLKQHSKLEILKQILIGLHANAGRGDLKDIGVNNFGAMVVTAGVTLSPDATIVYQSPTGLFERKVKLSDL
>NC_022780.1|WP_023440038.1|473941_474568_-|hypothetical-protein
MKKIASIALLALVPLTLASCGSGNQKSGSQSSNATSKTEKVSEKASSKASSKKDQEASSSSKASSDSSSSAKDDQTSSSVASASSSTSKASNSAISSSSKSESNHNSSNKTNSNNLSRADLTAAEQQNNHQPLADETIQTSEAAINLVKAKYGDKGWKVAYSSVGKSSPIYFHVTSDHDGSYYVYANGVVQNAGGDLSDHASEIQNIK
>NC_022780.1|WP_023440037.1|471358_473893_+|M1-family-metallopeptidase
MAKITRLYDLFQPEHYDIFLDISRETKHFRGKTVIQGIAQQTEIALHQKDLEVKSVYVNDEKTPFEIDSANEVIRLQLSQAGNVTLTVEYEAELTDSMMGIYPSYYEVDGVQKQLVGTQFETTFARQAFPGIDEPEAKATFDLAIKYDEHDGETILSNMPEIKAVDGIHYFDTTVKMSTYLIAFAFGDLQSKMTKTTSGVQVGVFATKAHQAQELDFALDIAKRSIEFYEEFYHTAYPLPHSWQLALPDFSAGAMENWGLVTYREAYLLLDPKNTALEIKQLVATVIAHELAHQWFGDLVTMQWWDDLWLNESFANMMEYVAIDAIEPDWHIWEMFQTSDVPAALQRDATDGVQSVHVQVQNPAEIDALFDGAIVYAKGARMLVMVRALIGDEALRTGLKQYFNNHQYGNAKGADLWAALGEAAGIDVGAIMHSWLEQPGYPVVNVEVVDGQLTISQQQFFIGEGQNAGRQWQIPLKGNYEVVPQILDQPTLSLGDYQQLRNENGQPFRLNVGNESHFIVHYSKDLLADILGALDQLGAIDQLQILQDLRLLAEGNQISYAEIVPLLEKFADSSSAVVNDVLYRLAGDLKKFVQPDSEEEANLQKLFNQLSAKQVQRLGWKPRTAESNDDQLTRPYVLGAALYAKNPEAILAAHELFEQNQNQLSNLSADIRSYVLSNEVKNFNNERLFKQLMEQYRQSTDPSYKADLSRALTATTDGKQIKAIIEKFEDASTIKPQDLRAWFRGLLANAKGQQLTWDWIRNDWKWLEDTVGGDMEFNTFITVIANIFRTPARLEEFKAFFEPKLQTPGLTREITMDIKVIEGRVKLIQAEKAAVNTAIEKIIA
>NC_022780.1|WP_023440036.1|469909_471310_+|MFS-transporter
MQESSTKKSNPMVVVAIVALMSFMGVLTETSMNVTFPALMQEFKVSLSTVQWVTAGYLLMAALVMLTSAYMKRRFTNRQLFVAAAILFGLGDVICGAALNFWVLLVGRLIQAGCVGLCTPLMVNIILEVVPQHKLGTYIGLANLIILTAPAMGPTFGGAVVAFASWRMIFWGTLPIALILMVLGSKKIKQYTPTQKQYAFDWTRFILLGLALVALIVGLNNLGSGAYISFIVLLLLSIGLITLFVKKSKNATKALFSLDVFKNKAFLFSFLPYIMLQFANVGINFLLPNYVQDVFQATSLIGGLILLPGSLLNGFGQPVYGWMLDNFGGKLPLYMGDILFTLALASLALWGPHMGVLGITIAYLIFAIGRSMAFGNSVAYGLKHINQELQNDANALYNTGQQVAGAIGTTILALMMGSVHHPGYTRAQNISAGSGWAFILLVILGLIILGFFHRLVNLDKQIKQTN
>NC_022780.1|WP_023440035.1|469120_469777_+|hypothetical-protein
MGIRIDITGKKFGKLVAKYPSGKAKNGNTKWHCVCECGQEKDVELQHLKSGGTKSCGNCSRMKYDLQGKRFARLTVLGRADKVSSNGNIYWLCRCICGKMIEADSYRLRTGNVKSCGCLRKEKAAQTIRKNAATAEQIGNSNAFKDRNGNPVQAVNIGARNTSGVIGVSFDHPSQKWVARMMHKGDLVLNATFLDFEEAVEARRRVEHKYLKNLSRTN
>NC_022780.1|WP_023440034.1|468198_468513_+|helix-turn-helix-transcriptional-regulator
MVKRFQFIRKNRKRKNLTIEQLAEKADVSIDLVARLERGEREDVSISKLESILHTLDLELGDVFKHSKLDKKSDEFVRKFLKLDAETREKYTDIFLSIIDLKNE
>NC_022780.1|WP_023440033.1|467643_468036_-|hypothetical-protein
MSNILISLLTLIAILFCWKSLYQNPARQIAGRKFYITKEYPTTYANAVDNLDRATIQFKKDGSIKYEVINDYSNDKWTINGHKVEMGNIADPDRTYIDLNDERQIDGHTFYEIKFEDDINIFQYFLVSEN
>NC_022780.1|WP_023440043.1|481658_482309_-|CPBP-family-intramembrane-metalloprotease
MKISKSSILTLITYLIIFLLPSILNVFINLGAGFIWVETVDYLIGALLLIFISSKTNEINHIESNRKSFLYAIAWGIIGTALVILLQFVISYITIIFGSNPTSQNTATLVTLAKTNPFFILAITVGAPIMEELVFRKVLFGNLSAMFGADSTLGFTVMAIISSLAFAFMHNDSHIFLYAAIGLLFCWLYKKTGRIQTSMIAHILMNSVVILPLVIK
>NC_022780.1|WP_002834471.1|482493_482778_+|co-chaperone-GroES
MLKPLGDRVILEAKDEEEQTVGGIVLASNAKEKSQTGKIIAVGNGTVLDNGQTVPMNVKVGDTVVYDKYAGTEVSYEDKKYLVVHEKDLVAVVE
>NC_022780.1|WP_002834470.1|482805_484425_+|chaperonin-GroEL
MAKEIKFSEDARTKMLKGVDKLADTVKSTIGPKGRNVVLEQSYGSPTITNDGVTIAKAIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVNEGMKNVTAGANPVGIRRGIEKATSKAVEALHKMSHEVKTKDDIAQIASISSANPEVGKLIANAMEKVGNDGVITIEESRGVDTTLDVVEGMQFDRGYMSQYMVTDNDKMEANLDNPYILITDKKIGNIQDILPVLQSVVEQSRSLLIIADDITGEALPTLVLNKMRGTFNVVAVKAPGFGDRRKEQLEDIAILTGGTVITDDLGLNLKDVTIEQLGQSNKVTVTKDDTTIVEGAGSQEQIAERVGIIKQQISETTSDFDKEKLQERLAKLSGGVAVIRVGAATETELKEKKYRIEDALNATRAAVEEGFVPGGGTALANVISDLEDVEAEGDEATGVNIVRRALEEPVRQIAENAGEEGSVIVTKLKGQKPGVGYNAANDEWVDMVEAGIVDPTKVTRSALQNAASVSALLLTTEAVVADLPEDNPAPAAPAPGMGGMM
>NC_022780.1|WP_002834469.1|484768_486601_+|APC-family-permease
MFSYLKRILIGKPLKTLDESGQALTKFKALALLSSDALSSIAYGTEEILSVLIVLSAAATWYSIPIAGIVLVLLFAITVSYRQIIKAYPSGGGAYVVASKNWGTSAGLVAGGSLLVDYMLTVAVSVTSGTEAITSAIPALQKYHIAIAVLIVLGIMALNLRGLRESASFLTIPVYLFIVVISLMIVVGLYNIATGQVAYHAASAVGSAVPGMTFVIFLRALSSGSSSLTGVEAISNAVPNFKKPRRKNAAGTLAIMSLILASFFAGITFLAYYSGITPSSSQTVLSQIGVTIFGHGIFYYILQLSTALILAVAANTGFSAFPMLAYNLAKDKFMPHAYMDRGDRLGYSNGIISLAAGAIVLILIFGGQTGLLIPLYAIGVFVPFTLSQSGMIVHWKREGGKKWMINASANLLGALLSAVLVICLLFLHFSNVWPYFIVMPLLLRMFYKIRKHYDEVADQLRVIEKGKVNLHDYDGSTVIVLVSNVTQVTSGAINYARSIGDYVIAMHVSFDANPEKEHKTAMEFKAEYPDVRFIDIHSSYRSITNPTLRFCDVIARRAAERNYTTTVLVPQFVPRKPWQNILHNQTGLRLRASLNSRENIIVSTYNYHLK
>NC_022780.1|WP_011673068.1|486751_487912_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MRFEIIVSLFATMIISAILTPFVRRISFKVGAIDKPTARRVNKVPMPTMGGLAIFIAFNFSLFFLLRNQIPNPQFYGIFFGECIILVTGIIDDIFELRPIQKMIGILLAALAVYLFANVRMTTLTFPFIGIVNFGWFSLPITLLWIAAITNAINLLDGLDGLATGVTIIALFTTGFTGLFFLPSTNIYIVIMIFTLVAAEIGFLPYNFFPARIYLGDTGALFIGFMISIFSLSGLKNATFITILIPVMILGVPLTDTVYAILRRLLNKESISHADKRHLHHRLMQMGLTHRQTVLVIYGISLIFSFIALLYPVSTLWGSVLLTIGILIGIEIFVEAIGLVGENRTPMLNWIRKLVRSNTSKVDSNEFKEENTLKDKVRTRSERHKK
>NC_022780.1|WP_023440044.1|487926_488580_-|YigZ-family-protein
MKPILSVKENFKIEQDIKKSRFITRIIPIQSEEEANQLLTEIRTTEAKANHNCFAYILGDQQDIQRASDDGEPSGTAGAPILEVLKRENLTNVLIVVTRYFGGIKLGAGGLIRAYGSSTSLAVNNAALIQLVDQELLSIKLDYQNNDQLVYYLEQHHLNQLETEYTTQVTTTISISKEQLEPLKKELIGLFSGNVAFKDLGTERVQIPYQKNEDDND
>NC_022780.1|WP_023440045.1|488612_489932_+|DEAD/DEAH-box-helicase-family-protein
MKEIEKQKYYGRLVLQPINAVPTDALDCRPAIVMKGNQIHCQRCGAITSSRDGALPDHQFYCRKCINLGRVSTLVQLATIPEPNNFVANQSYLEWPGKLTAPQARCSKAIINSIDQQQNRLLWAVTGAGKTEMIFPGINHALQKQKRICVASPRIDVVLELFPRFQEAFPQAKIALLHGRSPAPYEYTQFVLCTTHQLLRFYHAFDVLIIDEVDSFPYAMNPELHYATKQARKLQGSTIYLTATPDGKLLQQSRQAKLATSYLTRRFHGHPLPEIKVVSGQNWMKKLRKGRLPSPLSRFIKEQIQAQRQFLIFVPKIEVLPKVLEALQQAFPTVKVLTVHAADPERVAKVQMMRKQEIDALITTTILERGVTFPGIDVAVLGADDAVFSMTALVQIAGRVGRSPQRPKGTVLFICPMLNRNIKRAQAQIKFMNRKASEC
>NC_022780.1|WP_023440046.1|490171_490603_+|ComF-family-protein
MRNFFQHYKFQGDYLLRKVFQDQFVNFIQKILKENELIVPIPVDESTMTSRGFNQVTGLMEGLDWKDVLINQRSNDSLHQFQRSRRERLQQDSSFILKSGCDISGEHILLVDDIYTTGATLRQARTTLLRNGATQARSVTLCR
>NC_022780.1|WP_023440047.1|490733_491288_+|ribosome-associated-translation-inhibitor-RaiA
MLDFNVRGENIEVTEAIRDYVEKRIGKIEKYFEQGANPKAHVNLKVYQDKTAKVEVTIPLPYLVLRAEETSPDLYASVDLVTDKLERQLRKYKTKINRKSRETGYKGVEIPSGDIVENEEETSQFDIVRTKQVSLKPMGSEEAILQMDMLGHNFFIYEDAESGSVDIVYRRRDGRYGLIESAND
>NC_022780.1|WP_002834462.1|491448_493809_+|preprotein-translocase-subunit-SecA
MANILKKWVESDARELKRLGKKADKIEALKEEMEQLNDEKLKAKTTEFKERLQNGETLDDILVEAFAVAREAAKRVLGLFPFRVQLIGGMVLHGGNIAEMKTGEGKTLTATLPVYLNALGGKGVHVVTVNEYLAERDSSEMGELYKWLGLTVGVNSSEMTPDQKREAYNCDITYSTNSEIGFDYLRDNMVVYKEDMVQRPLNFALIDEVDSILIDEARTPLIISGQTEPTVTLYERADRYVKTLADGDYTIDWESKSISLTENGIRRAENFFKTDNLYDVENSALNHHIDQALRANYIMTKDKDYVVSDGEVLIVDSFTGRVMEGRRFSDGLHQAIEAKEHVEIQDGAKTMANITYQNLFRMYRKLSGMTGTARTEAEEFREIYNMEVTTIPTNRPVARDDRPDLLYPTLESKFKAVVKEIRDLHIKGQPVLVGTVAVETSEYLSRLLDREGIPHVVLNAKNHAREAEIVTNAGQKGAVTIATNMAGRGTDIKLGPGVVELGGLAVIGTERHESRRIDNQLRGRSGRQGDVGMSQFYLSLEDDLMIRFGSERIKDLLSRMKIADEDAVIRSGLISRQVESAQKRVEGNNYDARKNVLQYDDVMRAQREVIYAERQQVIMEETSLKDVLMPMVDRTIDRVVDAHTQKTQKNFDLETIVEFARTALVSDKDIHQADVEGMSAKEIKDYLKQLADQMYIEKEKALYDPAQILEFEKVVILRVVDQHWTDHIDAMDQLRQSVGLRGYGQLNPLVEYQQEGYRMFNEMITDIEYETTRLFMKSEIRQNLQR

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Crispr_ID: NC_022780_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022780_2

687444-687549

Orphan

Consensus_repeat	Method
TTAGCTCAGTTGGGAGAGCATCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022780_2

>merge|NC_022780|2|687444-687549|CRISPRCasFinder
TTAGCTCAGTTGGGAGAGCATCTGCCTTACAAGCAGGAGGTCACAGGTTCGAGCCCTGTATCCCCCATTATATTTTGAGCCGTTAGCTCAGTTGGTAGAGCATCTG

>NC_022780|2|2|687444-687549|CRISPRCasFinder
TTAGCTCAGTTGGGAGAGCATCTG	CCTTACAAGCAGGAGGTCACAGGTTCGAGCCCTGTATCCCCCATTATATTTTGAGCCG
TTAGCTCAGTTGGTAGAGCATCTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022780.1\|WP_023440213.1\|678733_679909_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340844
NC_022780.1\|WP_002833902.1\|675807_676074_+\|phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
NC_022780.1\|WP_002833906.1\|671787_672633_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
NC_022780.1\|WP_023440212.1\|677870_678644_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NC_022780.1\|WP_002833905.1\|672632_672995_+\|DUF1634-domain-containing-protein	unknown	unknown	gnl\|CDD\|377927
NC_022780.1\|WP_023440221.1\|700834_701554_+\|16S-rRNA-pseudouridine(516)-synthase	unknown	unknown	gnl\|CDD\|211327
NC_022780.1\|WP_002833742.1\|692208_693399_+\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NC_022780.1\|WP_029257840.1\|673049_675269_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NC_022780.1\|WP_002833901.1\|676073_677798_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NC_022780.1\|WP_002833897.1\|680988_682023_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103
NC_022780.1\|WP_023440219.1\|695542_696175_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NC_022780.1\|WP_023440222.1\|701576_702416_-\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576
NC_022780.1\|WP_023440218.1\|694986_695550_-\|rRNA-methyltransferase	unknown	unknown	gnl\|CDD\|377744
NC_022780.1\|WP_002833746.1\|696519_698937_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NC_022780.1\|WP_023440217.1\|693473_694940_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_022780.1\|WP_023440216.1\|691304_692036_-\|hypothetical-protein	unknown	unknown	unknown
NC_022780.1\|WP_023440220.1\|699140_700826_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NC_022780.1\|WP_023440214.1\|679958_680975_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NC_022780.1\|WP_023440215.1\|689501_691235_+\|pyruvate-oxidase	unknown	unknown	gnl\|CDD\|213733
NC_022780.1\|WP_023440211.1\|675473_675662_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022780.1\|WP_023440213.1\|678733_679909_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340844	cd03817, GT4_UGDG-like, UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.	7.6672e-136
NC_022780.1\|WP_002833902.1\|675807_676074_+\|phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	1.69391e-54
NC_022780.1\|WP_002833906.1\|671787_672633_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.61547e-34
NC_022780.1\|WP_023440212.1\|677870_678644_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.60194e-23
NC_022780.1\|WP_002833905.1\|672632_672995_+\|DUF1634-domain-containing-protein	gnl\|CDD\|377927	pfam07843, DUF1634, Protein of unknown function (DUF1634). This family contains many hypothetical bacterial and archaeal proteins. A few members of this family are annotated as being putative transmembrane proteins, and the region in question in fact contains many hydrophobic residues.	1.23608e-28
NC_022780.1\|WP_023440221.1\|700834_701554_+\|16S-rRNA-pseudouridine(516)-synthase	gnl\|CDD\|211327	cd02553, PseudoU_synth_RsuA, Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.	3.42886e-87
NC_022780.1\|WP_002833742.1\|692208_693399_+\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NC_022780.1\|WP_029257840.1\|673049_675269_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NC_022780.1\|WP_002833901.1\|676073_677798_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NC_022780.1\|WP_002833897.1\|680988_682023_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	8.50457e-33
NC_022780.1\|WP_023440219.1\|695542_696175_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.3233e-52
NC_022780.1\|WP_023440222.1\|701576_702416_-\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	1.95428e-76
NC_022780.1\|WP_023440218.1\|694986_695550_-\|rRNA-methyltransferase	gnl\|CDD\|377744	pfam06962, rRNA_methylase, Putative rRNA methylase. This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.	6.94849e-74
NC_022780.1\|WP_002833746.1\|696519_698937_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NC_022780.1\|WP_023440217.1\|693473_694940_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.58197e-64
NC_022780.1\|WP_023440220.1\|699140_700826_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.71664e-136
NC_022780.1\|WP_023440214.1\|679958_680975_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.73524e-32
NC_022780.1\|WP_023440215.1\|689501_691235_+\|pyruvate-oxidase	gnl\|CDD\|213733	TIGR02720, Pyruvate_oxidase, pyruvate oxidase. Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an enzyme with FAD and TPP as cofactors that catalyzes the reaction pyruvate + phosphate + O2 + H2O = acetyl phosphate + CO2 + H2O2. It should not be confused with pyruvate dehydrogenase [cytochrome] (EC 1.2.2.2) as in E. coli PoxB, although the E. coli enzyme is closely homologous and has pyruvate oxidase as an alternate name. [Energy metabolism, Aerobic].	0

>NC_022780.1|WP_002833897.1|680988_682023_+|flippase-like-domain-containing-protein
MSRRNKVVLAVMILAGIIIFGFSLRNVNLNQMARDVVHLNMWWLLVALGCIVLYLGLEAVATKMLIQSNGDRLSWRDAIRIPLIEQLFNGITPFSSGGQPAQLVALMQNGIEGGRASSVLLMKFVVFQSMVVINFIFSLLIGFQYLEEKIRFLSWFVLFGFLIHLAVIIGLLMIMYWHNFTKRLISAIFIPIKHFVSKERYTTWKVTLNEKVDSFYQESVRMKSQWRLLAKVALVTFLQLLFYYLIPYFILLALGKSDVNIVMVTCLHVLIFMVISLFPIPGGAGGAEYGFSVIFAQFVGNNSKLVLAMMIWRILTYYFGMFAGMVATVVKPHKVNRVKVVKNE
>NC_022780.1|WP_023440214.1|679958_680975_+|glycosyltransferase-family-4-protein
MPIKVNMFSSASKVKGQGVGSAYEELIRLLKTHFPKQIDVSINKFTKADISHYHTIDPNFYLSTFSKKRGIKVGYVHFLPETIEGSLNIPQPFRSIFYKYIISFYKRMDHIVVVNPTFIDKLVAYGISRDIITYIPNFVRKNEFYRFTEANRDAVRERLEVNNRFTVLGIGQVQERKGVKDFIKLAENNPDKYFIWAGGFSFGRLTDGYADLKQVVDNPPRNLKFTGIVDRNALVEYYNAADLFLLPSYNELFPMSVLEAFSCGVPVMLRDLELYHSIIKGYYIPTQDYEHMNTQLKLVSEDKERLNKFKQLSDEASEEYSEDHLADIWLDFYSSLTK
>NC_022780.1|WP_023440213.1|678733_679909_+|glycosyltransferase-family-4-protein
MNIGLFTDTYFPQVSGVATSIKTLRDQLEKQGHQVYIFTTTDPKVDTNVYERNIFRFTSVPFVSFTDRRIAVSGFIRAAQLAKELNLDIVHTQTEFSLGWMGKFVAKSLKIPLIHTYHTMYEDYLHYVANGKLLKPYHVKQMTRAFCYHIDGIVAPSERVLDTIEGYGINVPIRVIPTGVNLEQYQKPNKRKQWREKLGYDESSPILLSLSRLAHEKNIQEVIDSFPAILKEVPNAQLLIVGDGPARASLENQVHDLHLEDSVQFTGEINNDHVYGFYQLADLFVSASDTESQGLTYIEALASNLKVVAKSGPYTDELLDDISLGKVFNTEDQLVAAIKDYIEHPDAYNDPAPREKKLYEISADYFGKQVVDYYSSAISTHTDLELDEDSE
>NC_022780.1|WP_023440212.1|677870_678644_+|alpha/beta-hydrolase
MKLKLKSGAQIFFEDEGQGTPILFLTGFGGNTEIWSGQVNFFLQRGYRVIRLDYLNHGQSDRVDGELQIGDLADEVLQLVDYLQLKEPIGIGNSMGAAVLWNIINLRGWGFLSKAIFVDQSPKMLNDQQWHLGFKNLAEDNFDEVMNEPIVRPAYKHIDDFVFKNSKAIDSAYPFSQPQNRTLVKGHAKKDWRFVLEQATKPVLFIMGEKSPFFDSTKTAELSALNANITVNVMKNVGHIPMAEDPAEFNRLVLQFV
>NC_022780.1|WP_002833901.1|676073_677798_+|phosphoenolpyruvate--protein-phosphotransferase
MAGTLKGIAASDGIAIAKAYLMVDPDLSFEKKNITDVDAEIKRLHDALEKSKEELSLIKAKAAENLGAEEAEVFEAHLTILSDPELIGNIEDKIKNDTINAEEATKEVTDNFISMFEAMTDNAYMQERAADIRDVTKRLMSHLLGVELPNPALIDSEVVIVAHDLTPSDTAQLDRRYVKGFITDIGGRTSHSAIMSRTLEIPAVVGSEKATTSVKQGEMMIVDGLTGDAIIAPTDDEIKAYQQKGEEFKAQKAEWEKLKNEKTVSKDGVHFDLAANIGTPDDLQGVLDNGGEAVGLFRSEFLYMNASELPSEDEQFEAYKKVVEGMNGKQVVVRTMDIGGDKELPYLPLPEEMNPFLGYRAIRISLDRTDLFRTQLRALLRASAFGKLAIMFPMIATVAEFKKARAIYDDERQKMVDAGQEVGEIQVGMMMEIPAAAMIADKLAKYVDFFSIGTNDLIQYSFAADRGNEKVSYLYQPYNPSLLRLIKQTIDASHAEGKWTGMCGEMAGDQIAVPILMGLGLDEFSMSATSILKTRSLMKKLTTDDMKKLAEKAVTEAETNEDVIKLVQETVDNI
>NC_022780.1|WP_002833902.1|675807_676074_+|phosphocarrier-protein-HPr
MEKRDFHVIAETGIHARPATLLVQSASKFNSDIQLTYKDKSVNLKSIMGVMSLGVGQGADVTISADGDDEADAIAALEDTMKKEGLSD
>NC_022780.1|WP_023440211.1|675473_675662_+|hypothetical-protein
MRDYLQLLNDLKDGSIKELKITAEEFQDFQPRFMEFPERKQVIGKADRGGVVVYHFERIKDK
>NC_022780.1|WP_029257840.1|673049_675269_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MLCQNCQKNEASIHLYTNVNGQRTEVNLCQNCYQLLKNQRNNNINRNGGARMAQDPFGFGNLDDIFRAMQGGNMGQPENLYGQQVPPTQPGGGNGSGGNPNNRGNGGSLLSQYGLNLTDLAKQGKIDPVIGRDSEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQRIVEGSVPQKLVNKQIVRLDVVSLVQGTGIRGQFEQRMQQLMKEVQANKDMVVFIDEIHEIVGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEEEAIKILKGIQKKYEDYHHVHYTDDAIEAAVKLSKRYIQDRFLPDKAIDLLDEAGSKKNLTINIADPETIQKKIDEAEAQKKAALQSEDYEKAAYYRDQVSKLEKNKDGATSSEEQPTVTEEDMEKIIETKTDIPVGDLQKQEQEQLQNLSENLKDHVIGQDEAVDKISRAIRRNRIGLNGTGRPIGSFLFVGPTGVGKTELAKQLAQQLFGSKDSMIRFDMSEYMEPHSISKLIGSPPGYVGYEEAGQLTEQVRRHPYSLVLLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGTGDVQADVGFGAAAQGKTHSVLDKLGNYFKPEFLNRFDDIVEFQALTKENLMQIVDLMIADVNSMLATQGLHVDVTKPVEERLVDLGYNPKMGARPLRRVIQEQIEDRIADFYLDHPAEKQLNAKIKDDQIEITGAPKKD
>NC_022780.1|WP_002833905.1|672632_672995_+|DUF1634-domain-containing-protein
MNAKKQEMQHVELVIGRVLQVGVYISALVILLGIGLWLFKNGSGYSGALPTRITPIFHGVLAFKPYAVLMFGIFLLILTPVLRVIVSIYAFAKEGDRLYVVITTIVLVILIIGMAIGYRG
>NC_022780.1|WP_002833906.1|671787_672633_+|sulfite-exporter-TauE/SafE-family-protein
MASHLIILLLVGLMAGIFGAILGIGGGMIITPVLTVAMGLDIKYAIGASIIAVIATSSGATIAYLKDEMLNLRVAMFLEIATTVGAIVGAIMTGIFNSTVLFVLFGSFLVFSSWNMYRKLRRGGGEEGSTKNDRLANQLNLNGSYYDKALKKNVDYQVENVPGGSAVMFGAGLASGLLGIGSGAFKVMAMDNIMKMPLKPSSATSNLMMGVTAAASAMVYFFNGSIHADIAGPLAIGILFGAQLGSRIMQHLQPRWIRMIFIPVLLYMGLQMILKGFGVNI
>NC_022780.1|WP_023440215.1|689501_691235_+|pyruvate-oxidase
MTEKINASDAMIKVLESWGVHNVYGLPGGSFDSTMNALYNRKSTINYVQVRHEEVGALAAVGEAKVTGKLGVTFGSAGPGAVHLLNGLYDAKHDHMPVLALVGQVPTTLMNTDYFQELNENPIFTDVAVYNRTVMTAEQMPHVVDEAIRQAYKYSGVAVVTIPKDLGWQPIEDNYVSSANLYQAPILPEPDVKQVDEALEILSNAKHPVMYIGQGTRGAGSDIIALSEKLHIPIVTSALAKGIVPDSYKANMGSAGRVATKPGVEVLQAADAVMFVGSDFPFQPYFVAPDAKYIQVDIDASKFGRRHVVDLAILADSHKFLKVMLEKAETTAESKWYKAALENKKNWEEWKNSFVGQQDTPLNVENVFAKINALATDDAIFQVDVGNVTIDGMRFLKADQAQRFTTSGWYATMGYALPAAIGAQAEYPDRQVWSISGDGGYAMVMQDVLTQVKYHMPIINVILTNESLGFIEAEQDDSKQPHSGVDLIDADYGTSAQALGAEGFEVRIYDELEQAFEKAKDRKGPVVIDVKITNLRPLPVEQLLLDKETQDPEAVEQFVKKYHAESLIPFRKLLEEA
>NC_022780.1|WP_023440216.1|691304_692036_-|hypothetical-protein
MNKINLPKFNYPIEKKSYLPAINALLLSVVPWYLSSHFSSEIFSKHLSIQILFFLATFMVNFLTIDRLTNKTNLRLMAPLAIIPILTFIILLFSENTYVALLGLLSFVPFLTTFLPFEQKNGVGLLTFSLSVGTLAPLAFFYIRNGFVTSILLKMGLLLSLMIIVILFAIFIKTSFKFAIFALALTLIITIFAFILLKSWTALIYPILAVFSWFIPKLHLPRNFTLLVLIALIGLASFFITIN
>NC_022780.1|WP_002833742.1|692208_693399_+|methionine-adenosyltransferase
MSERHLFTSESVSEGHPDKIADQISDSILDELLKNDPDARVACETTVTTGLVVVVGEISTTAYIDIQKVVRKTIKDIGYVGGEYGFDGENCAVIVAIDEQSPDIAQGVDDSLETREGHEDRLNQIGAGDQGLMFGYATNETEELMPLPIMLSHHLMQRIAKLRKEQVISYLRPDAKAEVTVEYDDNDHPVRVDTVVLSTQHDPDVTLEQIRQDVIEQVIKAVIPATLLDENTNFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGAARHGGGAFSGKDATKVDRSASYAARYIAKNIVAAKLAERVEVQIAYAIGVAEPVSVMVDTFGTGTVSEEKLTQAVRKIFDLRPAGIIEMLDLKRPIYKQTAAYGHFGRTDVELPWEKTDKVEALNDFFKN
>NC_022780.1|WP_023440217.1|693473_694940_+|MFS-transporter
MEKKQTNVVVVTVAIFVATFMSAIEGTIVSTAMPTIVGDLHGVSLMNWVISIFLLTNAIFTPIYGKLSDIFGRKRVFIFGIIIFLIGSMLSGMAHSMGFLILWRALQGIGAGSIMPVSNTIIADIYPIEKRAKVMGLNGSAWGIASIIAPLLGGFIVDNLSWHWIFFINLPIGIITIFLIQFFLKEEVSVHSKKIDYLGSFWLMVALLGLMYGFQLMGESSFSWITLVISFVIFIVGAGLFIRQEKRAEDPIIFLDLFNNRTFVIQNVATMLVSGLLIGFEVYLPSWTQGILGVPASLAGFAVTPSSILWIFGSFLAGRMIVKLKANQILTISLSILAVGSLLLALVPASTPFLAFFFIAAILGVGFGITITSTLVISQQLVTKDRIGVATSFNTLAKTLGQTIMMSVFGIIMNGTMNAGVKANPKINMDMMNKVINPQTAKTLPETLLPTLRNVLYQALHNIYIGCFILIVVALIINAFDRRSKENI
>NC_022780.1|WP_023440218.1|694986_695550_-|rRNA-methyltransferase
MLDNAMQYSHQLLTEIVQPGDVVIDATMGNGNDTLFLSELVQSTGRVFSFDVQKVALEQTRALFEHQHQPLTNVELIHASHDQIDHYVTEPITGAIFNLGYLPGGDKSIITHPASTISAVQQSLNQLKIGGRIILVCYYGHPGGQEELQQLLSFVAELDQHHYSCLRYEFINQINNPPILLCIERKK
>NC_022780.1|WP_023440219.1|695542_696175_-|phosphatase-PAP2-family-protein
MHSRKYTHLLINILPTLLFILIVSLVIFKPSWVHAYDNSISSLVQSVRTPGFNQVVSIYTQLGNSIPYIIISLIVCLILFLKHLKKAALFLACNIVLGNGLNHLIKQIIQRQRPEFRLISIGGYSFPSGHSVAAMVLFGSLIFITFQVVHHQLKRNLLALIYLILMLGIGLSRIYLNVHFPTDVTAGFLLGLIVLQFTTYLFYGRKIKNA
>NC_022780.1|WP_002833746.1|696519_698937_+|leucine--tRNA-ligase
MAYNHKDIEQKWQQFWSDNETFKTVEDADKPKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRMKRMQGYKVLHPMGWDAFGLPAEQYAMKTGNNPRDFTAKNIQNFKRQIQSLGFSYDWSREVNTTDPAYYKWTQWIFEQLYKKGLAYEKETLVNWAPDLMGGTVVANEEVVDGKTERGGFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSVGASVFFNVEDSEKQIEVFTTRPDTLFGATYLVISPEHDLVDQITTPESKAAVEEYKKAVATKSDLERTDLNKDKTGVFTGAYAVNPVNGKKIPVWISDYVLASYGTGAVMAVPAHDGRDYEFAKKFKIDMVPVYEGGNLEDGVLDSEGGLINSGFLDGMDKQTAIDTMISWLEEHGVGHKKVNYRLRDWVFSRQRYWGEPIPVIHWEDGETTLIPEDELPLRLPAATDIRPSGTGESPLANLDDWVNVVDENGRKGRRETNTMPQWAGSSWYFLRYVDPKNDQKIADEDLLKEWLPVDLYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTLRLYEMFMGPLTESVAWSEDGLNGSRKWIDRVWRLMIDDENQLRDHIVTENDGSLDMIYNQTVKKVTDDYENMRFNTAISQMMVFVNEAYKADKLPAVYMEGLVKMLAPIIPHVAEELWSLLGHEGGISYAEWPTYDESKLVEATVQVILQVNGKVRSKITVDKDIAKEELEKLALADAKIQQWTADKTVRKVIVIPNKIVNIVVG
>NC_022780.1|WP_023440220.1|699140_700826_+|polysaccharide-biosynthesis-protein
MDKQSEMDNSESLYMGSQPLRDNSGKSSSKAKMLEGSAWMTAGSIFSRILGAIYIIPWVIWFGVYSDQANALFTKGYNIYSFFLIAAIAGIPSAISKQVSHYNAINEFALGQRLYKRGLLLSVGTGIICAAILYFGAPFLKDGDPNVITVLHALAWAVLVIPTMSLTRGFFQGYQEMGPSAVSQFIEQLARVIYMLTTAYFIMGKSGQGDWVYGVSQSTFAAFIGALGGLLVLGIYFIKYRKRLSYLSQHSANELVVSTSTLYKEIIAQAVPFIIIGSAITIFQLIDQYTFFRIMNAVSDYSTAILNNMYAIFAFNANKLVMIVISLASAMAVTSVPILSEAKTRGDRAEISRQVTDSILLFAFLMIPAALGMAAVAQPAYTLFYHLSDVGTAILQFNSYVAIVLGLFTVISAIMQGIGENVLAVKYFCVGMIVKFIFQFPMVALFSAVGSLISTAIGFMVVNWLILRHINLEYGLDYRRINTFIGKIITYAFGTFLIAMVVTNGLYIVMDPASKAQSLLVIAAAVVLGGAFYLYFVLKSRLADEIVGARAAGLRRMLKIS
>NC_022780.1|WP_023440221.1|700834_701554_+|16S-rRNA-pseudouridine(516)-synthase
MRVDKFLHDMNMGTRTQIRKMIKDKLIFVNDTVVKTGRVKVDPVIDEVRLKDQVIEYQQYFYFMMNKPLGVLTATEDRKQKTVMDLFNKVDLRSDLFPVGRLDKDTQGLLLITNNGQLAHDLLAPERHVDKTYEAVVTGKITVQAVEEFQKGITLKDGTTLKPAQLIIEHYSELDDQTVVKVVLKEGKYHQVRRMFGSLGEKVVTLRRTSFGPLELDVGLLPGTYRELTDDEINRLVEG
>NC_022780.1|WP_023440222.1|701576_702416_-|NAD(P)H-hydrate-dehydratase
MLKINQDGLNDLWPVRSNDSHKGSYGRILIVAGNDQYGGAGILSSSAAVYAGGGLVTLATDKSNFTAVRSTLAEVMLLDFLDFDALKAALKKSTGVVIGPGLGTNATSLKILKFVLDHVQPQTPLVIDGSAIDLIATHQIQVDHPQTIFTPHQMEWQRLSGIKIADQAPMLNQRAVDHLKAIVVLKHYETEIYAPHTDFRQIMAGNPGMATGGSGDALTGVIIALVNQVDSLALGVTLGTFLHSYTADQIYQKEAVVLPHRLIRRLPFTLKQLQKNKLL

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Crispr_ID: NC_022780_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022780_3

1712969-1713081

Orphan

Consensus_repeat	Method
TGACTTCCTGAATCTAACTGTTGAACGCC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NC_022780_3

>merge|NC_022780|3|1712969-1713081|CRISPRCasFinder
TGACTTCCTGAATCTAACTGTTGAACGCCGCTAATCAAGGTTCCTGTGCTTCCATTTAGAGTTTGAAGTCCGCTATTCAATGTGTGACTTCCTGAATCTAATTGTTGAACGCC

>NC_022780|3|3|1712969-1713081|CRISPRCasFinder
TGACTTCCTGAATCTAACTGTTGAACGCC	GCTAATCAAGGTTCCTGTGCTTCCATTTAGAGTTTGAAGTCCGCTATTCAATGTG
TGACTTCCTGAATCTAATTGTTGAACGCC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022780.1\|WP_011673877.1\|1715535_1715856_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NC_022780.1\|WP_002834191.1\|1708870_1709584_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NC_022780.1\|WP_023440868.1\|1725503_1726934_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NC_022780.1\|WP_023440857.1\|1709619_1710273_-\|nitroreductase	unknown	unknown	gnl\|CDD\|380313
NC_022780.1\|WP_023440866.1\|1722898_1723624_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|376350
NC_022780.1\|WP_023440855.1\|1707328_1708711_-\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NC_022780.1\|WP_011673875.1\|1711297_1711933_-\|DUF4767-domain-containing-protein	unknown	unknown	gnl\|CDD\|374270
NC_022780.1\|WP_023440854.1\|1705970_1707314_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NC_022780.1\|WP_002834184.1\|1702590_1703571_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NC_022780.1\|WP_023440852.1\|1703573_1704692_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|213783
NC_022780.1\|WP_023440862.1\|1717536_1718376_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|236841
NC_022780.1\|WP_023440858.1\|1710355_1711033_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|376540
NC_022780.1\|WP_080668937.1\|1715947_1716493_-\|DUF1836-domain-containing-protein	unknown	unknown	gnl\|CDD\|378076
NC_022780.1\|WP_023440863.1\|1718795_1720601_-\|DUF2207-domain-containing-protein	unknown	unknown	gnl\|CDD\|378333
NC_022780.1\|WP_002834264.1\|1720743_1721856_-\|low-temperature-requirement-protein-A	unknown	unknown	gnl\|CDD\|377704
NC_022780.1\|WP_023440851.1\|1701284_1702598_-\|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
NC_022780.1\|WP_023440867.1\|1723620_1724823_-\|GGDEF-domain-containing-protein	unknown	unknown	gnl\|CDD\|143635
NC_022780.1\|WP_023440861.1\|1716470_1717334_-\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NC_022780.1\|WP_023440853.1\|1704703_1705690_-\|lipoate--protein-ligase	unknown	unknown	gnl\|CDD\|161920
NC_022780.1\|WP_023440864.1\|1722009_1722846_+\|manganese-catalase	unknown	unknown	gnl\|CDD\|252986

Protein	Function_ID	Function_description	E-value
NC_022780.1\|WP_011673877.1\|1715535_1715856_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	8.63436e-15
NC_022780.1\|WP_002834191.1\|1708870_1709584_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	7.53435e-55
NC_022780.1\|WP_023440868.1\|1725503_1726934_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.67072e-61
NC_022780.1\|WP_023440857.1\|1709619_1710273_-\|nitroreductase	gnl\|CDD\|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	1.09e-37
NC_022780.1\|WP_023440866.1\|1722898_1723624_-\|EAL-domain-containing-protein	gnl\|CDD\|376350	pfam00563, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.	2.08096e-21
NC_022780.1\|WP_023440855.1\|1707328_1708711_-\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	3.38333e-173
NC_022780.1\|WP_011673875.1\|1711297_1711933_-\|DUF4767-domain-containing-protein	gnl\|CDD\|374270	pfam15983, DUF4767, Domain of unknown function (DUF4767). This domain family is found in bacteria, and is approximately 140 amino acids in length. There is a single completely conserved residue Q that may be functionally important.	4.49139e-48
NC_022780.1\|WP_023440854.1\|1705970_1707314_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	4.22992e-117
NC_022780.1\|WP_002834184.1\|1702590_1703571_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	2.88289e-177
NC_022780.1\|WP_023440852.1\|1703573_1704692_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl\|CDD\|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	1.57227e-159
NC_022780.1\|WP_023440862.1\|1717536_1718376_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|236841	PRK11088, rrmA, 23S rRNA methyltransferase A; Provisional.	4.94669e-40
NC_022780.1\|WP_023440858.1\|1710355_1711033_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	2.34907e-15
NC_022780.1\|WP_080668937.1\|1715947_1716493_-\|DUF1836-domain-containing-protein	gnl\|CDD\|378076	pfam08876, DUF1836, Domain of unknown function (DUF1836). This family of proteins are functionally uncharacterized.	1.90432e-35
NC_022780.1\|WP_023440863.1\|1718795_1720601_-\|DUF2207-domain-containing-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	4.11179e-114
NC_022780.1\|WP_002834264.1\|1720743_1721856_-\|low-temperature-requirement-protein-A	gnl\|CDD\|377704	pfam06772, LtrA, Bacterial low temperature requirement A protein (LtrA). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes.	1.87144e-45
NC_022780.1\|WP_023440851.1\|1701284_1702598_-\|2-oxo-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	1.72148e-159
NC_022780.1\|WP_023440867.1\|1723620_1724823_-\|GGDEF-domain-containing-protein	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	9.43646e-50
NC_022780.1\|WP_023440861.1\|1716470_1717334_-\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	3.39083e-94
NC_022780.1\|WP_023440853.1\|1704703_1705690_-\|lipoate--protein-ligase	gnl\|CDD\|161920	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase. One member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus. [Protein fate, Protein modification and repair].	3.42561e-88
NC_022780.1\|WP_023440864.1\|1722009_1722846_+\|manganese-catalase	gnl\|CDD\|252986	pfam05067, Mn_catalase, Manganese containing catalase. Catalases are important antioxidant metalloenzymes that catalyze disproportionation of hydrogen peroxide, forming dioxygen and water. Two families of catalases are known, one having a heme cofactor, and this family that is a structurally distinct family containing non-heme manganese.	2.41801e-119

>NC_022780.1|WP_011673875.1|1711297_1711933_-|DUF4767-domain-containing-protein
MRHMKKPEKRSFGSINSVVWVILALIVVIAGYKFFYPNHVTNTTSSSDRSSSTKVIKVEEGKSSSSKAQSSSKKTKKTEKKIWTDKQDSELAAFISSWQQTMGQTYTGTNANASVSFGGVSFPDYLSKGQIYVNQQEVSMQWTRSEKADSEYKVVAVYTGDQYMYLFTFHNGQPEVLVTSQSASNGMNFKVTENADLVAEFQKVAAENTDK
>NC_022780.1|WP_023440858.1|1710355_1711033_-|helix-turn-helix-domain-containing-protein
MQFFKMLKARRKQLDITQKELADKLYVTRQAVSRWENNLGYPNLDVLIRISEILELSLDELLKGKEEVDVVNKISKDVRSKKMYKRISIIVSTILAALVAFLFLFGYGRYTQNNMIDRFNPFLATKYGYGVLPEKYKVSKVDTFISDNPFGDGEWLRFETGQYAKQDKWVVVAHKGSYVSSVRNISDKEIPPTLRTQVGTEYFKYNKKAMGPRISKKLNWLPFNS
>NC_022780.1|WP_023440857.1|1709619_1710273_-|nitroreductase
MEVKQAIQKRHSVRHFTDQKIDSKQLKEMIGIAQKAPSWVNSQPQKVYVAQGETLEAIRKQQQELAITGAKINSDIPPMSRKLWSEQAQKNMAEWSHGIPAVLGDNWQETLGKEASQLYNAQAVVYLTLPKGYTPWSLFDLGAFSQNILLVTTEQGIDSIVAYNFVKYPQILREELKIPDDEEIIVGIGLGFEDEQVQVNRITSKRMDTESILKIKK
>NC_022780.1|WP_002834191.1|1708870_1709584_+|GntR-family-transcriptional-regulator
MYKYEKISQAIRKQIIEQKIKPGALLPDQNQLAKEFNTTRITIGKALQSLIIEGLIYSKRGAGTFVRKDAHLNDEFTNDVDKPLGTTSTHPHSKVTSKYIHLTARIANEVEKKNLLLEDGETVYVIKRTRFIEGKAYSYEQTIMPTKIATITEEVLKKSIYQYLEHEYHLELAGSHRQITARKVSEEDAKFLGEKLGDPILVISQTSYLVDGTPFEFSESRFPYQSSAVSADVNLLE
>NC_022780.1|WP_023440855.1|1707328_1708711_-|glycoside-hydrolase-family-1-protein
MKGKLPDNFLWGNSTSSMQTEGGVHEGGKGPSVYDTYEATETTSNWDVAIDNYHHYEEDLDLMANQGMNCYRFQISWSRINPTGDGDFNEEGIQYYDRLINDLLKRGIKPMICLYHFDMPLHLAEKYNGFMSRHVVDAFVRFGKKMVDCFSDRVKLWVTFNEQNLYSQTEAFHIAGYLKGDQTDEELQLIAHHVMTAHAQIANYVHETSDAQIGGMLAYVESYPKNCRPRDVYVARQIDEFLNRNLLEVWVHGHYSTEVTQYIKNHHFDIDFTEQDQIAFEKLKSDFISFSYYASNVVDSTKISQGTMPNRYLDYGGVENPYLKATDWGWNIDPLGFRDVITKTYNEYGIPMFPIENGIGYREIFDGTEIQDDYRIEYHRDHIQAMIDAVVEDGVPVLGYLGWGLIDIPSSSGNMEKRYGMVYVNRGNHELRDMKRVPKKSYKWFKKVIETNGNDLENDL
>NC_022780.1|WP_023440854.1|1705970_1707314_-|PTS-sugar-transporter-subunit-IIC
MGSSNKESVNDKMQNSKFIAKFTEISVKVGNWVYLRSLRDAFAVILPMFIVAGIGVLLNNVVFTWFLSGDMLTKFQVIGNAIVNGTLNVAGILVAPMIGYSLARNKGFNNPIAAAAMSLASIFILMPGSIQLGTVASAGAKMATVTGGLSYLNTGTQGMFGGIFVGLIATGLFIKLASIKKLQIHLGENVPPAVSASFSVLIPAILLMSFFAIIAALLAGFFNTDLINLIKTWIQEPLRGFNTSIVGYCVIYTLANFLFGLGIHQTVLSGALLDPLVLVNMNENMTAYAHHQAIPNIITTSFVSNYTLIGGSGSTIALIIAILIFSKVKSSRQIAGLSLAPGIFNINEPMIFGFPIVFNLPLIIPFVLFPVVGSLMGYFATLWGWVSRTVVLVPWTTPPLIGPYLSTAGDWRAVILQILIIVVGVFLYLPFLKISERVSEIQAEENL
>NC_022780.1|WP_023440853.1|1704703_1705690_-|lipoate--protein-ligase
MRYVTYMGTDAYTNIATDTWLLNNLNAKEPVFALWQNNNAIIVGQNQNTFGEVNQDFVDEHQIEVVRRVTGGGAVYHDLGNLNFTLFVPIESAANVDFKKFSEPVLRALHTLGIDAEASGRNDLLVNGKKISGVAQRYAKGYLMHHGTLLFDSNVDTMVRSLNVADEKFISKAAKSVRSRVGMIKDAAPKGLTLQDFWDAVQYELTDHGKDQEIVLTPQQKQEIIQLTANKFSTWDWNYGRSPEFNFKNHAKYDGGIIDVQVQAEGGTIRDINFTGDFLGLRDWREIKDQFIGLPFETAEIKTVFERNHEGRYFGNITDDELIKLFEA
>NC_022780.1|WP_023440852.1|1703573_1704692_-|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MAVKDDNKQVLDFNLQMEKQTDSFPMLQVLNNDGEIVDEDALKEAGLNEDQLVELMKQMVFSRVLHERSTKLAKQGRLGFYAPTIGEEASQIASNYAFEKGDWLFPGYRDIPQLVMKGWPIYKAFLWSRGHYEGNKFDDVNGWMPQIIIGAQYVEATGAALGLKMRKQPNVAYAYTGDGGTSQGDFYEGMNFAGAYNAPAVFFSQNNEYAISTPRKLQTKAPHLAAKGWAAGLPSLVVDGMDPIAMYLASKKARQWAVDGNGPVFIETITNRLGAHSMSGDDPLRYRTQEEIDEWTKKEPLIRFRKYLEGLGLWSEEIENDWTEVVNEQIDDGVKQADGIDKQKISDFIEQTLEVPGQAAQEQINKFRGEGK
>NC_022780.1|WP_002834184.1|1702590_1703571_-|alpha-ketoacid-dehydrogenase-subunit-beta
MAQKTYIQAITEAQDLALANDENVVIFGEDVGKNGGVFRATDGLQAKYGEDRVFNTPLAESGIGGMAIGMTTQNYRPIMEIQFFGFVYEVMDSLAGQMARGRFRFHGTRTFPIVVRSPYGGGTKTPEMHADSLEGLVAQTPGLRVVMPATPADAKGLLLSAVESNDPVIFLENLRLYRSIRGDVPEGYYTTPLDKANVIREGKDVSIITYGGMVHTSLAAAEELAKDGIDAEVVDLRTVSPLDLDTIGESVEKTGRVVVAQEAQRQAGIGAMVMSEISERFIMSLKAPIGRVAAPDSVYPFALAENEWLPKADDIIEKVKEVVNFD
>NC_022780.1|WP_023440851.1|1701284_1702598_-|2-oxo-acid-dehydrogenase-subunit-E2
MTEIFKMPDIGEGMAEGEIANWLVKVGDTIKEEDAVAEVQNDKLLQEILSPYGGKITKLFVEAGTVVKVGEPLIEFDGDGSGAGAESEAPKETPASTEPEPESSAPVNQTAPEVTKVGAEYTSNGQLLAMPSVREYARKNDIDLTQVPATGRHGHITMADVENFKASPASAPTASPALAASVPETESEKAPSAPVTPAAPAEVKAGRVPLSPVRKVIAKTLTNQVQTIPHVTIMDEVEVSKLMDLRNQFKEQAKQKGYKLTYMPFIAKALAGAAHKYPELSAMVDIEKQEIVYYEDTNVSFAVDTDNGLFVPNVKNVKSKSIMEVAQEIDDMAIRGRAGDLKPNELKGGTVTITNIGSESGSGFFTPIINPGESAILGIGRIRKTPVVNEDGELAVGNTLKLSLSFDHRLIDGALAQKIMNELKALLSNPAYMLMEV
>NC_022780.1|WP_011673877.1|1715535_1715856_-|winged-helix-turn-helix-transcriptional-regulator
MVKNNAALAAFKKNIPLLDALSDERRQQIMITLGESDAGLTVSELTKLIGLSQPAVSHHIKQLKDLNLVSVRKVGTSNIYQLTIKDALAQVQELIDILRKDKKLLR
>NC_022780.1|WP_080668937.1|1715947_1716493_-|DUF1836-domain-containing-protein
MVYKLLNKVIEGDQMDSKQLENFAKMSLPKWDELPNIELHLDQVIDLANNYLRPLEVDLLTPTMMHNYLKQAVIIRPQGKLYGRVQLAAVIIIGCLKSILSLYEIKRGFEAELKLTSSRRAYNNFVNAFNEEVQRISQHGPRNLWNELLAETAVVSLQHSAIISMLTKKMAKDLLSDLEEK
>NC_022780.1|WP_023440861.1|1716470_1717334_-|DegV-family-protein
MLKQKIAVLVDSCSDVPAEIANREYFEMIPMGVFFGEEEYQDRVNIEPDEFYQKLAKANPLPTTASPKGELITKALDNLSKRGFTKIIAVCISSGLSGTAQQVKIYAKNYPQLQIEVIDTKNIGIASGFAAVRASEVIEEGWEFDQIIEEVQRVANQTKVFFYVPTLKYLIAGGRIGRVAGLVGSIINLKPIISCDDEGIYYPVAKAHGEKKALKKMLQLVDDTLKNAQKFNLAVVHGLNEGLMNQISTEFKNKYPNMGKFYNGDISPALGVHTGPGLIGIGVQIIK
>NC_022780.1|WP_023440862.1|1717536_1718376_+|methyltransferase-domain-containing-protein
MNKIELATQFIQRHLHQFQCPICKSNFNEVQSGTLICNNQHSFNIAKKGSLFFLNNPVNTEYTNEMLTYRNQFLTAGFFNPMLEEVINNISGDLILDAGCGEGTTTKWMASHFDGDFVGLDISKPAINIAGFGIAPQPYPLFMVGDLAQLPFADQGLTSIVNILSPANYQEFDRTLATHGELIKVIPGNHYLSELRQLVYPDGEHATYDNAPVKNHFIEHYEHVEFSKISYKFPLDDKLFTALFNMTPLTWQAQDRKEAILQDGLKEITAEFEIGVVRK
>NC_022780.1|WP_023440863.1|1718795_1720601_-|DUF2207-domain-containing-protein
MKFFTKRTFLLLVTMLTFDIFWNVKTVKADYEISQFRMQINVNKDGSANINQSVLYDFDDDYHGVYLTQDLRGTAGAELEGITVSNNKGTQNQVPINNSGENLTAKVESSKKQMKIKVYNAVSSDDQTKITYHYRINGVVTNYKDTAEINWKVIGSGWDVPLEDAQVTIKLPGKNVKGLHAWSHGEAAGYTTVDKAKGKATLDIGDNPENTFVEAHMVFPTALTPDNKKIVNQNHLAAVKKQEYQLVKRENEAQARARRIAAYAKITSAMISVLILIGMMGWLKKHGYHQYDIPTPMEHSFDVPSISPAEAEALFNKSKADTKGVSAEMLVLAAEGKLKFKQIPYGKRGKETTEIERQGKFNMSFVDRCLDRIGDGQQVTIKQINDYAKKDKKNNVATWYKEWQSEVDANLARFKDTYNISYRHGLLGLAITTPILAFIVGIIGRFGEVTNLYWIGGIVLTLIIEAWVLATWDKVSMYNEAGLQQYNQIRGFKQMMKDIAHFNTAEIGDLILWEQILPYATAFGLAERVAKKLKTDFGTQLNENVPFYAYYYGINGMHAGIANSISTSISHSVSASSSGSSGGFSGGSSGGFGGGSGGGAF
>NC_022780.1|WP_002834264.1|1720743_1721856_-|low-temperature-requirement-protein-A
MKNELLKKVSMIELFYDLVFVYMISQVTGLIHHLQNGVISPSALSIFTLVVIVSINSWMVQTVFNNRYGKSQWSNVILSFVDMAIVLYMSNAFSDTFDRHLIGFFIAAGLLSLTLAIQYLLVFVQTKNEYDRNIAMAFMRILFFRTACLLAGGVLAGRWGTTIALFGIITSWIIPAFTGKHTQKHPIIFSHLLERLTALIIIMFGETIVGISKYFTQNTFSIQSIMIFIIVVSLFFTYIVEFDHLIEEQRTHETGNLLIYLHYFILFGLSLVTVALDFIHESEANAIFSITCLYVGIALFYIGIVIASYYNKTTLKLENYVVVAFIVVTLMGYFTSMCFATFSIIAGVTALTTLINAVVITLSLVRRYER
>NC_022780.1|WP_023440864.1|1722009_1722846_+|manganese-catalase
MFKHQKELQFETKPDRPDPIVAKYLQELIGGQYGEMSVAMQYLFQGWSCRGEEKYKDMIMDIATEEIGHVEMLATMVARLLEDAPIADQQAAMQANPTVGAIISGMNPQHAIVAGLGPRPADSVGNPWSGAYIIASGNLLADFRANLNAESQGRLQVARIYEMIDDQGVKDLLSVLLARDSYHQNLWASAVKELEEKEDSMLVPTTFPRDKERKDIAYDFYNFSQGDESSTGPWASGEALDGEGEYHWYDEPKVEGSAPNLKPVSPKMYGTPENKSKI
>NC_022780.1|WP_023440866.1|1722898_1723624_-|EAL-domain-containing-protein
MSELEQKLEGICFYEQPIFLIDAAEKEEKKVIGSELLLRKTGGENRFPAMLYKEYMRDDASNLVFCTWLVKNIIEIINDNPGIQYSFNLDPQQLLYDSTFEAMKGLIPYCDRVMIEVTESIPSNRDIDQYFNYSVRDQIKRIHEMGFSVAVGDVSSGMNSFNAVREYTQDIDRLKLSLIQLRNVEEGMITVTISLWKALAANTGIDLVIEGIDSLEVSKWLLENGLEKQQGYYFATPRKLK
>NC_022780.1|WP_023440867.1|1723620_1724823_-|GGDEF-domain-containing-protein
MENTVMNTIIYWAKGFFSFNTVVIAAITVGVLFMLAAGTYVVEMNMDKTKTSSTLIEELLWGVGLTIAMVFLQNVFTHLYSTIASSELGWEYSTAQFVVLFYCLYIVHRKVVLWFNIILPMYVYGLGIVRGQIGFDIAPILAILVIILISYTIYQQNDTLIDENVKYYSTLIMFGLAWWFVLKDIHHLTIVDIMCLTLEFLIAMSIVHFGNKKVRMIMKQYLNLMQEVDTDALTGVYNRNSFNKVVEGVFEFYSNNDAPLTMVMFDIDHFKQFNDQYGHQVGDKVLRLVADRFSYELVDRKAHGQLFRVGGEEFAIIFRGRTADDCEKIVRAIRDDLVKETIRVNNHDRVGIKVSIGISQLRDDDFDFQTFYKRVDDYLYQSKRNKRNSITVEGKVASLN
>NC_022780.1|WP_023440868.1|1725503_1726934_+|MFS-transporter
MESTSFVNNPEIQKHRWWILIAVCSFTFMSTLDGSIINIALPVMSSTMHVPMNKAEWVVSIYLIVICTLLLLFGKLGDAHGKIRVFKVGTMLFTIGSLLCGFNTGLTFLLIARIIQAVGAAMTMSTNNGIITEVFPAQERGRALGMIGSFVALGSIAGPGIGGLILAHFNWGYIFWINVPIGLLAILVGHKILPKDVIMTHQKIDKPGTILFAITMITLFVGISMGQEVGFTQPLILTMLFVALIALGTFLYVELHVETPILALYIFKNMRFTLSIICAFLIFITGFFFNVISPFYLENTLGLPANYAGYTLMIYPLINVVTAPVAGAISDKIGSEKLTFVGLLIILTAQLGYIVTNLATPLWLFMIFIGLNGLGNGIFQAPNNALVMGSVEPKDLGIAGGINSLARNLGMVVGISFATTVLFSAMSHIAGHSVTSVVPGHPEIFIAGMHVAFTVSFGVCLIATLITGYRLLHRQK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NC_022780_1	1.6\|481263\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481263-481292	30	NC_022780.1	562684-562713	2	0.933

1. spacer 1.6|481263|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to position: 562684-562713, mismatch: 2, identity: 0.933

aataaaaaaacctccatccgaagacagagg	CRISPR spacer
aacaaaaaaacctccatccgaagatagagg	Protospacer
**.*********************.*****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022780_1	1.1\|480933\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	480933-480962	30	MG592473	Vibrio phage 1.101.O._10N.261.45.C6, partial genome	82299-82328	6	0.8
NC_022780_1	1.4\|481131\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481131-481160	30	NC_007105	Bacillus cereus E33L plasmid pE33L54, complete sequence	47448-47477	6	0.8
NC_022780_1	1.4\|481131\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481131-481160	30	NZ_CP040339	Bacillus luti strain FJ plasmid unnamed3, complete sequence	38950-38979	6	0.8
NC_022780_1	1.4\|481131\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481131-481160	30	NZ_CP009966	Bacillus cereus E33L plasmid pBCO_2, complete sequence	48017-48046	6	0.8
NC_022780_1	1.2\|480999\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	480999-481028	30	NZ_CP050186	Bacillus thuringiensis strain HER1410 plasmid pLUSID3, complete sequence	27956-27985	7	0.767
NC_022780_1	1.7\|481329\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481329-481358	30	NC_011738	Gloeothece citriformis PCC 7424 plasmid pP742401, complete sequence	150710-150739	7	0.767
NC_022780_1	1.8\|481395\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481395-481424	30	NZ_CP012940	Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence	135867-135896	8	0.733
NC_022780_1	1.8\|481395\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481395-481424	30	NZ_CP012944	Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence	47763-47792	8	0.733
NC_022780_1	1.8\|481395\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481395-481424	30	NZ_CP051295	Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence	135611-135640	8	0.733
NC_022780_1	1.8\|481395\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481395-481424	30	NC_017575	Ralstonia solanacearum Po82 megaplasmid, complete sequence	1884402-1884431	8	0.733
NC_022780_1	1.8\|481395\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481395-481424	30	NZ_CP026308	Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence	1884346-1884375	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP041590	Acinetobacter baumannii strain J9 plasmid pJ9-3, complete sequence	73256-73285	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	CP033569	Acinetobacter pittii strain 2014N21-145 plasmid p2014N21-145-1, complete sequence	95389-95418	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP033130	Acinetobacter wuhouensis strain WCHAW010062 plasmid pOXA23_010062, complete sequence	203986-204015	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	CP033531	Acinetobacter pittii strain 2014S07-126 plasmid p2014S07-126-1, complete sequence	182790-182819	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP042557	Acinetobacter baumannii strain E47 plasmid pE47_001, complete sequence	322669-322698	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP010351	Acinetobacter johnsonii XBB1 plasmid pXBB1-9, complete sequence	12848-12877	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP029396	Acinetobacter defluvii strain WCHA30 plasmid pOXA58_010030, complete sequence	235199-235228	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP048828	Acinetobacter baumannii strain ABF9692 plasmid pABF9692, complete sequence	99261-99290	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP032285	Acinetobacter sp. WCHA55 plasmid pOXA58_010055, complete sequence	369421-369450	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP042365	Acinetobacter pittii strain C54 plasmid pC54_001, complete sequence	232229-232258	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_MK134375	Acinetobacter baumannii strain 34AB plasmid p34AB, complete sequence	155693-155722	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP038010	Acinetobacter haemolyticus strain TJR01 plasmid pAHTJR1, complete sequence	285078-285107	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP043053	Acinetobacter pittii strain AP43 plasmid pAP43-OXA58-NDM1, complete sequence	201107-201136	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_MH220287	Acinetobacter ursingii strain RIVM0061 plasmid pRIVM0061_IMP-4_171109_B01, complete sequence	234319-234348	8	0.733
NC_022780_1	1.9\|481461\|30\|NC_022780\|CRISPRCasFinder,CRT	481461-481490	30	NZ_CP043309	Acinetobacter johnsonii strain Acsw19 plasmid pAcsw19-2, complete sequence	67010-67039	8	0.733
NC_022780_1	1.8\|481395\|30\|NC_022780\|PILER-CR,CRISPRCasFinder,CRT	481395-481424	30	NZ_CP021355	Rhodococcus sp. S2-17 plasmid pRB98, complete sequence	486229-486258	9	0.7

1. spacer 1.1|480933|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to MG592473 (Vibrio phage 1.101.O._10N.261.45.C6, partial genome) position: , mismatch: 6, identity: 0.8

ataatacaataatagtaaattccactgtat	CRISPR spacer
ctaatacaaaaatagtaaattcctcttgac	Protospacer
 ******** ************* **  *.

2. spacer 1.4|481131|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NC_007105 (Bacillus cereus E33L plasmid pE33L54, complete sequence) position: , mismatch: 6, identity: 0.8

tacgtttga--tatatcctaactctgcagctt	CRISPR spacer
--aagttgacttatatcctaactctacagctt	Protospacer
   . ****  **************.******

3. spacer 1.4|481131|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040339 (Bacillus luti strain FJ plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.8

tacgtttga--tatatcctaactctgcagctt	CRISPR spacer
--aagttgacttatatcctaactctacagctt	Protospacer
   . ****  **************.******

4. spacer 1.4|481131|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP009966 (Bacillus cereus E33L plasmid pBCO_2, complete sequence) position: , mismatch: 6, identity: 0.8

tacgtttga--tatatcctaactctgcagctt	CRISPR spacer
--aagttgacttatatcctaactctacagctt	Protospacer
   . ****  **************.******

5. spacer 1.2|480999|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP050186 (Bacillus thuringiensis strain HER1410 plasmid pLUSID3, complete sequence) position: , mismatch: 7, identity: 0.767

tgaagctgttcaaaatgcgcattatggagt	CRISPR spacer
tgaagctgttgaaaatgcggatttacaaat	Protospacer
********** ******** ***   .*.*

6. spacer 1.7|481329|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NC_011738 (Gloeothece citriformis PCC 7424 plasmid pP742401, complete sequence) position: , mismatch: 7, identity: 0.767

aaaagaacaactgagtagcctcccagggct	CRISPR spacer
taaagaacaactgaggagcatcccaactca	Protospacer
 ************** *** *****.  *

7. spacer 1.8|481395|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012940 (Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

taaatttcgtcattaagcttcctccagttc	CRISPR spacer
gtgaacgcgtcattccgcttcctccagttc	Protospacer
  .* . *******  **************

8. spacer 1.8|481395|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012944 (Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

taaatttcgtcattaagcttcctccagttc	CRISPR spacer
gtgaacgcgtcattccgcttcctccagttc	Protospacer
  .* . *******  **************

9. spacer 1.8|481395|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP051295 (Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.733

taaatttcgtcattaagcttcctccagttc	CRISPR spacer
gtgaacgcgtcattccgcttcctccagttc	Protospacer
  .* . *******  **************

10. spacer 1.8|481395|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NC_017575 (Ralstonia solanacearum Po82 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.733

taaatttcgtcattaagcttcctccagttc	CRISPR spacer
gtgaacgcgtcattccgcttcctccagttc	Protospacer
  .* . *******  **************

11. spacer 1.8|481395|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026308 (Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

taaatttcgtcattaagcttcctccagttc	CRISPR spacer
gtgaacgcgtcattccgcttcctccagttc	Protospacer
  .* . *******  **************

12. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP041590 (Acinetobacter baumannii strain J9 plasmid pJ9-3, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

13. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to CP033569 (Acinetobacter pittii strain 2014N21-145 plasmid p2014N21-145-1, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

14. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP033130 (Acinetobacter wuhouensis strain WCHAW010062 plasmid pOXA23_010062, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

15. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to CP033531 (Acinetobacter pittii strain 2014S07-126 plasmid p2014S07-126-1, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

16. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP042557 (Acinetobacter baumannii strain E47 plasmid pE47_001, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

17. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP010351 (Acinetobacter johnsonii XBB1 plasmid pXBB1-9, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

18. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP029396 (Acinetobacter defluvii strain WCHA30 plasmid pOXA58_010030, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

19. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP048828 (Acinetobacter baumannii strain ABF9692 plasmid pABF9692, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

20. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP032285 (Acinetobacter sp. WCHA55 plasmid pOXA58_010055, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

21. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP042365 (Acinetobacter pittii strain C54 plasmid pC54_001, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

22. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_MK134375 (Acinetobacter baumannii strain 34AB plasmid p34AB, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

23. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP038010 (Acinetobacter haemolyticus strain TJR01 plasmid pAHTJR1, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

24. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP043053 (Acinetobacter pittii strain AP43 plasmid pAP43-OXA58-NDM1, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

25. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_MH220287 (Acinetobacter ursingii strain RIVM0061 plasmid pRIVM0061_IMP-4_171109_B01, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

26. spacer 1.9|481461|30|NC_022780|CRISPRCasFinder,CRT matches to NZ_CP043309 (Acinetobacter johnsonii strain Acsw19 plasmid pAcsw19-2, complete sequence) position: , mismatch: 8, identity: 0.733

tgcgaccatcgctatacataagcatatttg	CRISPR spacer
aacttccatccctatacataagcataggta	Protospacer
 .*  ***** ***************  *.

27. spacer 1.8|481395|30|NC_022780|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021355 (Rhodococcus sp. S2-17 plasmid pRB98, complete sequence) position: , mismatch: 9, identity: 0.7

taaatttcgtcattaagcttcctccagttc	CRISPR spacer
cgcacccgctcatcaagcttcctccagttc	Protospacer
.. *...  ****.****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

493890 : 557195

Lactobacillus_phage(47.62%)

protease,head,capsid,holin,tail,terminase,portal,integrase

attL 494093:494109|attR 532714:532730

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_132981263.1\|493890_495006_+	peptide chain release factor 2	B5LLF2	Mycobacterium_phage	1.9e-05	47.1
494093:494109	attL	NA	NA	NA	NA
WP_002834460.1\|495017_495722_+	response regulator transcription factor	W8CYM9	Bacillus_phage	6.9e-38	37.3
WP_002834459.1\|495693_497079_+	two-component sensor histidine kinase	W8CYF6	Bacillus_phage	6.3e-27	33.3
WP_002834458.1\|497240_498122_+	phosphate ABC transporter substrate-binding protein PstS family protein	H6WG65	Cyanophage	9.3e-08	25.9
WP_011673073.1\|498121_499030_+	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
WP_002834456.1\|499030_499918_+	phosphate ABC transporter permease PstA	NA	NA	NA	NA
WP_011673074.1\|499935_500736_+	phosphate ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	3.4e-09	42.0
WP_023440049.1\|500749_501508_+	phosphate ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.7e-18	30.5
WP_002834093.1\|501519_502203_+	phosphate signaling complex protein PhoU	NA	NA	NA	NA
WP_041525485.1\|502340_502655_+	PspC domain-containing protein	NA	NA	NA	NA
WP_002834091.1\|502671_503028_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_002834090.1\|503045_503984_+	HPr kinase/phosphorylase	NA	NA	NA	NA
WP_023440052.1\|503995_504832_+	prolipoprotein diacylglyceryl transferase	NA	NA	NA	NA
WP_002834087.1\|504913_505930_+	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_023440053.1\|505953_506835_+	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	2.4e-72	50.9
WP_023440054.1\|506965_507892_+	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	3.7e-84	50.8
WP_023440055.1\|508048_509773_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	7.2e-182	54.6
WP_023440056.1\|509928_510558_+	HD domain-containing protein	NA	NA	NA	NA
WP_023440057.1\|510694_512698_+	excinuclease ABC subunit UvrB	NA	NA	NA	NA
WP_023440058.1\|512710_515554_+	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	1.9e-304	54.9
WP_002834080.1\|515652_516540_+	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	1.1e-11	33.1
WP_023440059.1\|516536_517538_+	YvcK family protein	A1IMD5	Streptococcus_phage	3.9e-95	56.7
WP_002834077.1\|517550_518480_+	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	4.0e-54	39.4
WP_023440060.1\|518656_521491_+	N-acetylmuramidase	A0A0N7IR99	Lactobacillus_phage	6.2e-37	47.4
WP_002834074.1\|521575_521848_+	hypothetical protein	NA	NA	NA	NA
WP_002834073.1\|521894_522488_-	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	1.6e-56	54.3
WP_023440061.1\|522842_523976_-\|integrase	site-specific integrase	E9LUS1	Lactobacillus_phage	1.5e-87	46.9
WP_023440062.1\|524276_525173_-	hypothetical protein	Q4ZE81	Staphylococcus_phage	9.7e-13	32.5
WP_023440063.1\|525253_525559_-	hypothetical protein	D2KRD5	Lactobacillus_phage	1.9e-16	50.0
WP_023440064.1\|525571_525913_-	helix-turn-helix transcriptional regulator	Q8W5Y0	Listeria_phage	6.1e-16	44.0
WP_023440065.1\|526181_526373_+	hypothetical protein	NA	NA	NA	NA
WP_023440066.1\|526373_526814_+	hypothetical protein	NA	NA	NA	NA
WP_023440070.1\|526959_527169_-	hypothetical protein	NA	NA	NA	NA
WP_023440071.1\|527227_528010_+	hypothetical protein	A0A1Q1PVU2	Staphylococcus_phage	3.2e-84	58.9
WP_023440072.1\|528062_528263_+	hypothetical protein	NA	NA	NA	NA
WP_023440073.1\|528384_528726_+	DUF771 domain-containing protein	NA	NA	NA	NA
WP_023440075.1\|528823_529045_+	hypothetical protein	NA	NA	NA	NA
WP_023440076.1\|529041_529323_-	hypothetical protein	NA	NA	NA	NA
WP_023440079.1\|529576_530209_+	hypothetical protein	NA	NA	NA	NA
WP_023440080.1\|530223_530622_+	single-stranded DNA-binding protein	D6PSU2	Lactobacillus_phage	8.9e-35	54.5
WP_023440081.1\|530644_531388_+	DNA replication protein	A7DYC7	Streptococcus_phage	9.4e-70	54.9
WP_023440082.1\|531368_532187_+	ATP-binding protein	O03914	Lactobacillus_phage	7.2e-63	49.6
WP_023440083.1\|532303_532714_+	RusA family crossover junction endodeoxyribonuclease	A0A0P0IXM5	Lactobacillus_phage	9.2e-43	60.3
WP_023440085.1\|532710_532929_+	hypothetical protein	NA	NA	NA	NA
532714:532730	attR	NA	NA	NA	NA
WP_023440087.1\|533176_533548_+	hypothetical protein	NA	NA	NA	NA
WP_023440088.1\|533547_533898_+	hypothetical protein	O03921	Lactobacillus_phage	5.4e-28	57.8
WP_023440089.1\|533937_534402_+	hypothetical protein	NA	NA	NA	NA
WP_023440090.1\|534426_534720_+	hypothetical protein	NA	NA	NA	NA
WP_023440091.1\|534720_535281_+	DUF1642 domain-containing protein	A0A1S5SB02	Streptococcus_phage	4.6e-13	42.9
WP_023440093.1\|535273_535672_+	hypothetical protein	NA	NA	NA	NA
WP_023440094.1\|535665_535935_+	hypothetical protein	A0A2K9VD68	Lactobacillus_phage	7.6e-22	61.6
WP_023440095.1\|535935_536229_+	hypothetical protein	NA	NA	NA	NA
WP_023440096.1\|536231_536429_+	hypothetical protein	NA	NA	NA	NA
WP_023440097.1\|536428_536596_+	hypothetical protein	NA	NA	NA	NA
WP_023440098.1\|536601_536988_+	hypothetical protein	NA	NA	NA	NA
WP_023440099.1\|537061_537505_+	DNA-directed RNA polymerase sigma-70 factor	O03925	Lactobacillus_phage	4.8e-13	34.8
WP_023440100.1\|538162_538618_+	HNH endonuclease	B8R694	Lactobacillus_phage	1.3e-24	38.3
WP_023440101.1\|538614_538902_+	hypothetical protein	NA	NA	NA	NA
WP_023440102.1\|538904_539237_+	hypothetical protein	NA	NA	NA	NA
WP_023440103.1\|539414_539879_+\|terminase	phage terminase small subunit P27 family	E9LUP8	Lactobacillus_phage	7.7e-38	52.7
WP_023440104.1\|539878_541753_+\|terminase	terminase large subunit	A0A0M7RDK9	Lactobacillus_phage	8.0e-142	41.4
WP_023440106.1\|541953_543066_+\|portal	phage portal protein	Q9AZM4	Lactococcus_phage	3.0e-64	37.4
WP_041525489.1\|543049_543640_+\|head,protease	HK97 family phage prohead protease	B8R651	Lactobacillus_phage	3.8e-42	47.6
WP_080668941.1\|543764_544964_+\|capsid	phage major capsid protein	D2KRA9	Lactobacillus_phage	5.4e-83	57.4
WP_023440109.1\|545044_545515_+	Ig domain-containing protein	A0A0M9JJ52	Lactobacillus_phage	7.9e-06	37.6
WP_080668931.1\|545831_546191_+\|head	phage head closure protein	A0A2P0ZLF0	Lactobacillus_phage	2.2e-16	40.4
WP_041525454.1\|546210_546606_+\|tail	phage tail protein	A0A286QQY0	Streptococcus_phage	6.6e-30	55.4
WP_023440113.1\|546605_546995_+	DUF806 family protein	A0A2P0ZLF4	Lactobacillus_phage	6.1e-12	29.5
WP_023440114.1\|546994_547603_+\|tail	tail protein	Q9AZL7	Lactococcus_phage	1.4e-34	41.0
WP_023440115.1\|547736_548150_+	hypothetical protein	NA	NA	NA	NA
WP_023440116.1\|548358_552888_+	peptidoglycan DD-metalloendopeptidase family protein	E9LUR1	Lactobacillus_phage	1.9e-80	33.0
WP_023440117.1\|552889_554659_+	hypothetical protein	U3PDQ7	Lactobacillus_phage	6.2e-19	24.1
WP_023440118.1\|554675_557195_+	hypothetical protein	A0A2P0ZLF8	Lactobacillus_phage	7.1e-85	31.0

DBSCAN-SWA_2

870544 : 876899

Megavirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011673326.1\|870544_872404_+	molecular chaperone DnaK	A0A2P1EIW2	Megavirus	5.3e-138	47.2
WP_002833625.1\|872500_873625_+	molecular chaperone DnaJ	A0A0P0YNN4	Yellowstone_lake_phycodnavirus	1.3e-22	33.2
WP_002833626.1\|873729_873957_-	DUF378 domain-containing protein	NA	NA	NA	NA
WP_023440321.1\|874085_874556_-	tryptophan-rich sensory protein	NA	NA	NA	NA
WP_023440323.1\|874792_875275_+	QueT transporter family protein	E7DN70	Pneumococcus_phage	1.7e-11	35.7
WP_023440324.1\|875291_875513_+	DUF2829 domain-containing protein	G3MBC9	Bacillus_virus	2.3e-08	34.4
WP_023440325.1\|875513_876254_+	3-oxoacyl-ACP reductase	Q06VL0	Trichoplusia_ni_ascovirus	4.1e-17	30.5
WP_002833631.1\|876377_876899_+	DUF4373 domain-containing protein	A0A0P0HRQ2	Lactobacillus_phage	4.0e-43	57.1

DBSCAN-SWA_3

937621 : 999988

Lactobacillus_phage(66.67%)

protease,head,capsid,holin,tail,portal,terminase,integrase

attL 938174:938191|attR 1000941:1000958

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_029257957.1\|937621_939037_-\|protease	ATP-dependent protease ATPase subunit HslU	A0A1B2IEP8	Erwinia_phage	3.9e-32	25.2
938174:938191	attL	NA	NA	NA	NA
WP_023440367.1\|939037_939592_-\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_023440368.1\|939610_940516_-	tyrosine recombinase XerC	A0A1I9SC88	Mycobacterium_phage	6.6e-17	29.7
WP_023440369.1\|940588_942661_-	type I DNA topoisomerase	A0A1V0SCS0	Indivirus	3.8e-92	34.8
WP_023440370.1\|942970_943630_-	beta-phosphoglucomutase	NA	NA	NA	NA
WP_023440371.1\|943645_945898_-	glycoside hydrolase family 65 protein	NA	NA	NA	NA
WP_023440372.1\|945923_947267_-	SLC45 family MFS transporter	NA	NA	NA	NA
WP_023440373.1\|947410_948364_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_023440375.1\|948461_949322_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	3.3e-26	33.6
WP_023440376.1\|949362_950130_-	ribonuclease HII	E3T5H8	Cafeteria_roenbergensis_virus	2.9e-26	42.6
WP_023440377.1\|950116_950980_-	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_023440378.1\|951329_953444_-\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	2.6e-117	39.3
WP_023440379.1\|953727_955773_-	hypothetical protein	NA	NA	NA	NA
WP_023440380.1\|955759_956098_-	hypothetical protein	NA	NA	NA	NA
WP_023440381.1\|956099_957158_-	DUF916 and DUF3324 domain-containing protein	NA	NA	NA	NA
WP_002833104.1\|957144_957798_-	WxL domain-containing protein	NA	NA	NA	NA
WP_023440382.1\|957954_958746_-	hypothetical protein	NA	NA	NA	NA
WP_011673390.1\|959977_960220_-	hypothetical protein	NA	NA	NA	NA
WP_023440384.1\|960337_960715_-\|holin	holin	A0A2K9VCG4	Lactobacillus_phage	3.7e-22	78.8
WP_023440385.1\|960724_960988_-\|holin	holin	E9LUR9	Lactobacillus_phage	7.2e-33	86.2
WP_023440386.1\|960987_962151_-	LysM peptidoglycan-binding domain-containing protein	D6PSS2	Lactobacillus_phage	2.7e-31	39.6
WP_023440388.1\|962162_962522_-	hypothetical protein	A0A2P0ZLF6	Lactobacillus_phage	1.4e-42	73.9
WP_023440390.1\|962670_962916_-	hypothetical protein	NA	NA	NA	NA
WP_023440392.1\|964847_967223_-	hypothetical protein	E9LUR3	Lactobacillus_phage	0.0e+00	68.9
WP_023440393.1\|967287_969054_-\|tail	phage tail protein	E9LUR2	Lactobacillus_phage	2.6e-219	62.7
WP_023440394.1\|969117_973662_-	peptidoglycan DD-metalloendopeptidase family protein	A0A2P0ZLG0	Lactobacillus_phage	0.0e+00	58.6
WP_023440395.1\|973693_973879_-	hypothetical protein	NA	NA	NA	NA
WP_023440396.1\|973923_974298_-	hypothetical protein	A0A2P0ZLH4	Lactobacillus_phage	6.6e-56	92.7
WP_023440397.1\|974368_975046_-\|tail	phage tail protein	A0A2P0ZLH1	Lactobacillus_phage	9.0e-112	94.0
WP_023440398.1\|975061_975442_-	DUF806 family protein	A0A2P0ZLF4	Lactobacillus_phage	1.6e-57	88.1
WP_023440399.1\|975441_975849_-	hypothetical protein	A0A2P0ZLE6	Lactobacillus_phage	1.9e-64	90.9
WP_023440400.1\|975851_976199_-\|head	phage head closure protein	A0A2P0ZLF0	Lactobacillus_phage	1.0e-42	72.2
WP_023440401.1\|976188_976521_-\|head,tail	phage gp6-like head-tail connector protein	E9LUQ4	Lactobacillus_phage	1.7e-42	81.5
WP_023440402.1\|976593_977823_-\|capsid	phage major capsid protein	E9LUQ3	Lactobacillus_phage	1.1e-205	90.9
WP_023440403.1\|977822_978578_-\|protease	Clp protease ClpP	E9LUQ2	Lactobacillus_phage	1.3e-122	92.0
WP_023440404.1\|978555_979719_-\|portal	phage portal protein	E9LUQ1	Lactobacillus_phage	4.2e-210	94.0
WP_011673412.1\|979721_979916_-	DUF1056 family protein	E9LUQ0	Lactobacillus_phage	4.8e-26	96.9
WP_023440405.1\|981806_982265_-\|terminase	phage terminase small subunit P27 family	E9LUP8	Lactobacillus_phage	5.8e-78	94.1
WP_080668942.1\|982463_982931_-	HNH endonuclease	E9LUP7	Lactobacillus_phage	1.1e-81	93.5
WP_023440407.1\|983172_984324_-	ImmA/IrrE family metallo-endopeptidase	A0A0A7RTT7	Clostridium_phage	3.3e-29	30.7
WP_023440408.1\|984354_985125_-	hypothetical protein	NA	NA	NA	NA
WP_023440409.1\|985818_986205_-	hypothetical protein	NA	NA	NA	NA
WP_023440410.1\|986226_986385_-	hypothetical protein	NA	NA	NA	NA
WP_023440411.1\|986407_986878_-	hypothetical protein	NA	NA	NA	NA
WP_051347449.1\|986932_987277_-	hypothetical protein	A0A2K9VCF6	Lactobacillus_phage	4.0e-23	54.5
WP_023440413.1\|987463_987631_-	hypothetical protein	NA	NA	NA	NA
WP_023440415.1\|987667_988132_-	hypothetical protein	NA	NA	NA	NA
WP_023440416.1\|988150_988522_-	hypothetical protein	NA	NA	NA	NA
WP_023440418.1\|988754_988973_-	hypothetical protein	NA	NA	NA	NA
WP_023440419.1\|988977_989379_-	RusA family crossover junction endodeoxyribonuclease	A8YQM5	Lactobacillus_phage	6.4e-33	52.9
WP_023440421.1\|990250_990649_-	single-stranded DNA-binding protein	D6PSU2	Lactobacillus_phage	6.8e-35	55.3
WP_023440079.1\|990663_991296_-	hypothetical protein	NA	NA	NA	NA
WP_041525463.1\|991482_991677_-	helix-turn-helix transcriptional regulator	A0A1X9I6I3	Streptococcus_phage	2.0e-08	51.6
WP_023440424.1\|991812_992622_+	hypothetical protein	NA	NA	NA	NA
WP_023440427.1\|992917_993127_-	hypothetical protein	NA	NA	NA	NA
WP_132981239.1\|993471_993675_+	hypothetical protein	NA	NA	NA	NA
WP_023440429.1\|993699_993903_-	DUF2829 domain-containing protein	A0A0N9SKI8	Staphylococcus_phage	5.2e-07	40.8
WP_023440430.1\|993950_994154_-	DUF2829 domain-containing protein	NA	NA	NA	NA
WP_023440431.1\|994199_994985_-	hypothetical protein	A0A1Q1PVU2	Staphylococcus_phage	1.5e-81	57.0
WP_023440432.1\|995044_995245_+	hypothetical protein	NA	NA	NA	NA
WP_023440435.1\|995446_995638_-	hypothetical protein	NA	NA	NA	NA
WP_023440437.1\|995653_995863_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_023440438.1\|996119_996467_+	helix-turn-helix transcriptional regulator	A0A1S7FZ25	Listeria_phage	1.4e-07	40.3
WP_023440439.1\|996475_996883_+	ImmA/IrrE family metallo-endopeptidase	A0A0M7RF74	Lactobacillus_phage	8.9e-06	32.3
WP_023440440.1\|996944_997538_+	DUF4352 domain-containing protein	A0A0P0IXE0	Lactobacillus_phage	2.3e-34	61.7
WP_023440441.1\|997776_997974_+	hypothetical protein	NA	NA	NA	NA
WP_051347451.1\|998113_998509_-	DUF2335 domain-containing protein	NA	NA	NA	NA
WP_023440443.1\|998555_998738_-	hypothetical protein	NA	NA	NA	NA
WP_023440444.1\|998914_999988_+\|integrase	site-specific integrase	Q9ZXG6	Leuconostoc_phage	1.2e-44	36.7
1000941:1000958	attR	NA	NA	NA	NA

DBSCAN-SWA_4

1026244 : 1035862

Staphylococcus_phage(37.5%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023440466.1\|1026244_1027090_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	1.0e-16	35.2
WP_023440467.1\|1027326_1028064_-	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.3e-34	40.4
WP_023440468.1\|1028060_1029512_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_132981240.1\|1029633_1030110_-	dihydrofolate reductase	A0A0N9S8H6	Staphylococcus_phage	2.2e-24	38.8
WP_011673474.1\|1030147_1031098_-	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	3.4e-117	62.7
WP_023440471.1\|1031110_1032988_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	5.0e-51	30.5
WP_041525465.1\|1032990_1034199_-\|tRNA	CCA tRNA nucleotidyltransferase	G3MAR3	Bacillus_virus	8.4e-36	29.8
WP_023440473.1\|1034452_1035337_+	YitT family protein	M1Q1P6	Streptococcus_phage	2.0e-50	37.8
WP_002833201.1\|1035391_1035862_-	nucleoside deoxyribosyltransferase	A0A1G5S9Z4	Enterococcus_phage	3.8e-16	40.1

DBSCAN-SWA_5

1398038 : 1406602

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023440668.1\|1398038_1398620_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.7e-22	34.7
WP_023440670.1\|1398616_1399666_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D8KLC2	Synechococcus_phage	3.1e-58	40.2
WP_023440671.1\|1399665_1401135_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.1e-56	33.3
WP_023440672.1\|1401119_1403327_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.1e-147	40.8
WP_023440673.1\|1403344_1404019_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_023440674.1\|1404021_1404276_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_023440675.1\|1404268_1404997_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SLB8	Cyanophage	8.1e-42	43.4
WP_023440676.1\|1404996_1406136_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_011673684.1\|1406119_1406602_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.6e-20	42.9

DBSCAN-SWA_6

1415431 : 1424298

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023440679.1\|1415431_1416448_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	5.6e-33	30.6
WP_002833272.1\|1416447_1416783_-	hypothetical protein	NA	NA	NA	NA
WP_023440680.1\|1416798_1417428_-	dTMP kinase	M1PSC7	Streptococcus_phage	3.3e-52	52.7
WP_023440681.1\|1417592_1418192_-	recombination protein RecR	NA	NA	NA	NA
WP_002833269.1\|1418218_1418533_-	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_023440682.1\|1418548_1420294_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	2.8e-56	48.4
WP_023440683.1\|1420505_1420991_-	nucleoside deaminase	A0A2H4PQS8	Staphylococcus_phage	1.4e-05	31.6
WP_023440684.1\|1420983_1421589_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_011673696.1\|1421800_1422031_+	glutaredoxin-like protein NrdH	A0A0M7REK7	Lactobacillus_phage	8.0e-12	48.1
WP_023440685.1\|1422132_1424298_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	3.3e-248	59.8

DBSCAN-SWA_7

1644863 : 1655709

Bacillus_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023440813.1\|1644863_1646039_+	class I SAM-dependent methyltransferase	A0A2K9L4K8	Tupanvirus	6.3e-44	33.3
WP_002834110.1\|1646180_1646513_-	AzlD domain-containing protein	NA	NA	NA	NA
WP_002834111.1\|1646533_1647322_-	branched-chain amino acid ABC transporter	NA	NA	NA	NA
WP_023440814.1\|1647453_1648710_-	D-alanyl-D-alanine carboxypeptidase	B6DZZ7	Stx2-converting_phage	3.5e-08	24.0
WP_023440815.1\|1648890_1650027_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	3.7e-25	25.8
WP_002834114.1\|1650038_1650728_-	response regulator transcription factor	W8CYM9	Bacillus_phage	5.7e-37	37.3
WP_023440816.1\|1650810_1651308_-	methylated-DNA--[protein]-cysteine S-methyltransferase	A0A2P1EI66	Megavirus	2.9e-14	38.1
WP_011673831.1\|1651438_1652581_-	guanosine monophosphate reductase	A0A1V0SHK8	Klosneuvirus	2.4e-64	34.0
WP_023440817.1\|1652602_1653307_-	DUF1129 domain-containing protein	NA	NA	NA	NA
WP_002834120.1\|1653335_1654442_-	redox-regulated ATPase YchF	NA	NA	NA	NA
WP_002834122.1\|1654658_1654844_-	DUF951 domain-containing protein	NA	NA	NA	NA
WP_023440818.1\|1654857_1655709_-	ParB/RepB/Spo0J family partition protein	S5VTK0	Leptospira_phage	2.1e-12	34.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022780

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection