CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NC_022878	Enterococcus mundtii QU 25, complete genome	4 crisprs	cas14j,cas9,cas1,cas2,csn2,csa3,RT,DinG,cas3,DEDDh	1	8
NC_022883	Enterococcus mundtii QU 25 plasmid pQY082, complete sequence	0 crisprs	RT	0	0
NC_022880	Enterococcus mundtii QU 25 plasmid pQY039, complete sequence	0 crisprs	RT	0	0
NC_022884	Enterococcus mundtii QU 25 plasmid pQY024, complete sequence	0 crisprs	NA	0	0
NC_022879	Enterococcus mundtii QU 25 plasmid pQY182, complete sequence	1 crisprs	c2c10_CAS-V-U3,RT	1	0
NC_022881	Enterococcus mundtii QU 25 plasmid pQY003, complete sequence	0 crisprs	NA	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NC_022878_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022878_1

334157-334245

TypeII

Consensus_repeat	Method
GGTTTTAGAGCTATGTTGAATTG	CRISPRCasFinder

1 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NC_022878_1

>merge|NC_022878|1|334157-334245|CRISPRCasFinder
GGTTTTAGAGCTATGTTGAATTGAATGCTTCCAAAACAACATACTTCATTAATGATCCTAAAAAGTCGTTTTAGAGCTATGTTGAATTG

>NC_022878|1|1|334157-334245|CRISPRCasFinder
GGTTTTAGAGCTATGTTGAATTG	AATGCTTCCAAAACAACATACTTCATTAATGATCCTAAAAAGT
CGTTTTAGAGCTATGTTGAATTG

Protein	Signature genes	Signature genes Name	Protein_function
NC_022878.1\|WP_023519014.1\|323368_324502_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176243
NC_022878.1\|WP_148294486.1\|324789_325593_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_023519017.1\|328237_332230_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
NC_022878.1\|WP_023519026.1\|347301_347754_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NC_022878.1\|WP_010734358.1\|343455_344751_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|376574
NC_022878.1\|WP_023519023.1\|339157_340612_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|163525
NC_022878.1\|WP_010736477.1\|327428_327557_-\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_023519018.1\|332208_333075_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NC_022878.1\|WP_010736481.1\|323014_323341_-\|YrhK-family-protein	unknown	unknown	gnl\|CDD\|372928
NC_022878.1\|WP_023519022.1\|337294_339130_+\|tyrosine-decarboxylase	unknown	unknown	gnl\|CDD\|163523
NC_022878.1\|WP_023519016.1\|325687_327382_-\|oleate-hydratase	unknown	unknown	gnl\|CDD\|237575
NC_022878.1\|WP_175401355.1\|322534_322993_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|173926
NC_022878.1\|WP_010736474.1\|334419_334782_+\|DUF1622-domain-containing-protein	unknown	unknown	gnl\|CDD\|377914
NC_022878.1\|WP_019724648.1\|334781_335138_+\|DUF1622-domain-containing-protein	unknown	unknown	gnl\|CDD\|377914
NC_022878.1\|WP_023519019.1\|333071_333416_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NC_022878.1\|WP_023519025.1\|346633_347233_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240029
NC_022878.1\|WP_041684361.1\|333405_334071_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd09758_csn2_CAS-II-A	gnl\|CDD\|213408
NC_022878.1\|WP_023519024.1\|340765_343315_+\|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl\|CDD\|319775
NC_022878.1\|WP_010736466.1\|345074_346517_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375760
NC_022878.1\|WP_023519021.1\|335365_336796_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022878.1\|WP_023519014.1\|323368_324502_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176243	cd08283, FDH_like_1, Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1. Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	2.94903e-175
NC_022878.1\|WP_023519022.1\|337294_339130_+\|tyrosine-decarboxylase	gnl\|CDD\|163523	TIGR03811, tyrosine_decarboxylase, tyrosine decarboxylase, Enterococcus type. This model represents tyrosine decarboxylases in the family of the Enterococcus faecalis enzyme Tdc. These enzymes often are encoded next to tyrosine/tyramine antiporter, together comprising a system in which tyrosine decarboxylation can protect against exposure to acid conditions. This clade differs from the archaeal tyrosine decarboxylases associated with methanofuran biosynthesis. [Cellular processes, Adaptations to atypical conditions].	0
NC_022878.1\|WP_023519017.1\|328237_332230_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	0
NC_022878.1\|WP_023519026.1\|347301_347754_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.7267e-20
NC_022878.1\|WP_010734358.1\|343455_344751_-\|ISL3-family-transposase	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	6.13503e-67
NC_022878.1\|WP_023519023.1\|339157_340612_+\|amino-acid-permease	gnl\|CDD\|163525	TIGR03813, put_Glu_GABA_T, putative glutamate/gamma-aminobutyrate antiporter. Members of this protein family are putative putative glutamate/gamma-aminobutyrate antiporters. Each member of the seed alignment is found adjacent to a glutamate decarboxylase, which converts glutamate (Glu) to gamma-aminobutyrate (GABA). However, the majority belong to genome contexts with a glutaminase (converts Gln to Glu) as well as the decarboxylase that converts Glu to GABA. The specificity of the transporter remains uncertain.	2.61194e-50
NC_022878.1\|WP_023519018.1\|332208_333075_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.53259e-118
NC_022878.1\|WP_010736481.1\|323014_323341_-\|YrhK-family-protein	gnl\|CDD\|372928	pfam14145, YrhK, YrhK-like protein. The YrhK-like protein family includes the B. subtilis YrhK protein, which is functionally uncharacterized. Its expression is under the control of the motility sigma factor sigma-D. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length.	3.01323e-13
NC_022878.1\|WP_023519016.1\|325687_327382_-\|oleate-hydratase	gnl\|CDD\|237575	PRK13977, PRK13977, myosin-cross-reactive antigen; Provisional.	0
NC_022878.1\|WP_175401355.1\|322534_322993_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	9.46857e-10
NC_022878.1\|WP_010736474.1\|334419_334782_+\|DUF1622-domain-containing-protein	gnl\|CDD\|377914	pfam07784, DUF1622, Protein of unknown function (DUF1622). This is a family of 14 highly conserved sequences, from hypothetical proteins expressed by both bacterial and archaeal species.	1.1401e-18
NC_022878.1\|WP_019724648.1\|334781_335138_+\|DUF1622-domain-containing-protein	gnl\|CDD\|377914	pfam07784, DUF1622, Protein of unknown function (DUF1622). This is a family of 14 highly conserved sequences, from hypothetical proteins expressed by both bacterial and archaeal species.	4.26891e-23
NC_022878.1\|WP_023519019.1\|333071_333416_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	7.60262e-43
NC_022878.1\|WP_023519025.1\|346633_347233_+\|NUDIX-hydrolase	gnl\|CDD\|240029	cd04672, Nudix_Hydrolase_14, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.06e-65
NC_022878.1\|WP_041684361.1\|333405_334071_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	4.02793e-105
NC_022878.1\|WP_023519024.1\|340765_343315_+\|HAD-IC-family-P-type-ATPase	gnl\|CDD\|319775	cd02080, P-type_ATPase_cation, P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase. This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NC_022878.1\|WP_010736466.1\|345074_346517_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375760	pfam18333, ssDNA_DBD, Non-canonical single-stranded DNA-binding domain. This domain is found in ThermoDBP, a non-canonical single-stranded DNA-binding protein in Thermoproteales. Single-stranded DNA-binding proteins are needed for DNA metabolism, sequestering and protecting transiently formed ssDNA during DNA replication and recombination, detecting DNA damage and recruiting repair proteins. The outer edge of the ssDNA-binding cleft, formed by this domain, has a strongly positive electrostatic surface potential because of the conserved basic residues R49, K54, R65, R80, R86, R90, K97, and R112.	2.76138e-24

>NC_022878.1|WP_041684361.1|333405_334071_+|type-II-A-CRISPR-associated-protein-Csn2
MNLNFSLLDQPMKFEHANFFIIEDVTVFAKMIQQLYTYKENGEVKLFNERHETIKESELMMITDILGFDINSAATLKLIYSDLERQLNEKPEVKSMITKLTDTISELIEYELLDHEMDLESDEITILELFKALGVKIETTSDTIYEKIIEILQVFKYLTKKKLLIFINVCSYLTLKEIEEIRSYISLCNMDVLFIEPRKIAGITQTILDNDYFLIDGSMVE
>NC_022878.1|WP_023519019.1|333071_333416_+|CRISPR-associated-endonuclease-Cas2
MSYRYMRMILMFDMPTETVDDRKAYRRFRKFLISEGFIMHQFSVYSKLLLNNTANQVMIGRLKGNNPKKGLITILTVTEKQFGRMIYLTGEKDQSIGNLDDRVIFLGEEFNDES
>NC_022878.1|WP_023519018.1|332208_333075_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRTLVINTHSKLTYTNNHLIFRNAERTEKIHLSEIDVLLLETTDITITTMLLKRLVDEKVLVLFCDDKRLPTAKLQPFYSRHDSSLQLTRQIEWKKDDKASVWTEIITQKINNQQRFLEKRLFTEKAEAIAQLTASLQLLDPTNREGHAARIYFQTLFGNKFTREADNAINAGLDYGYTLLMSLFAREIVKNGCMTQFGLKHANQFNDFNLASDLMEPFRPLVDQIVYEVREKEFPIIKRRLFDLFLTNYSYEKKEMFLTNIVADYTKKVIKALNKEAKGVPHFGI
>NC_022878.1|WP_023519017.1|328237_332230_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MEKEYTIGLDIGTNSVGWAVLTDDYRLVARKMSIQGDSNRKKIKKNFWGARLFEEGKTAQFRRIKRTNRRRIARRRQRVLALQDIFAEEIHKKDPNFFARLEEGDRVEADKRFAKFPVFATLSEEKNYHRQYPTIYHLRHDLANSKEQADIRLVYLAIAHCLKYRGHFLFEGELDTENTSVTENYQQFLQAYQQFFPEPIGDLDDAVPILTERLSKAKRVEKVLAYYPSEKSTGNFAQFLKLMVGNQANFKKTFDLEEEMKLNFTRDCYEEDLNELLEKTSDDYAELFLKAKGVYDAILLSQILSKSDDETKAKLSANMKLRFEEHQRDLKQLKELVRRDLPKKYDDFFKNRSKNGYAGYVKGKATQEDFYKFLRTELAGLEESQSIMEKIDLEIYLLKQRTFANGVIPHQIHLVEMREIMDRQKRFYPFLKGAQGKIEKLLTFRIPYYVGPLAQEGQSPFAWIKRKSPSQITPWNFAEVVDKENSAIEFIERMTNQDTYLPKEKVLPKQSLIYQRFMIFNELTKVSYTDERGKSHYFSSEQKRKIFNELFKQHPRVTEKQLRKFLELNEQIDSTEIKGIETSFNASYSTYHDLLKLSDQMDTLLDDPDMTTMFEEIIKILTIFEDREMIREQLKPYETVLGLPAIKKLAKKHYTGWGRLSEKMIQGMREKQSRKTILDYLIDDDDFPCNRNRNFMQLINDDHLSFKETIANELIMSDSNVLLDQVKAIPGSPAVKKGIWQSIKIVEEIIGIIGKAPKNIVIEMARENQRTSRSRPRLKALEEALKNIDSPLLKDYPTDNQALQKDRLYLYYLQNGKDMYTGEPLEIHRLSEYDIDHIIPRSFIVDNSLDNKVLVSSKVNRGKLDNAPDPLVVKRMRSHWEKLHQAKLISDKKLANLTKQNLTEADKARFIQRQLVETRQITKHVANLLHQHFNLPEEVSATEKTSIITLKSTLTSQFRQMFDIYKVREINHHHHAHDAYLNGVVAMTLLKKYPKLAPEFVYGSYIKGDINQINKATAKKEFYSNIMKFFESEEIICDEQGEVIWNKKRDLSTIKKTIGAHQVNIVKKVEKQKGGFYKETINSKANPEKLIPRKASLDPLKYGGYGSPLVAYTVIFIFEKGKQKKVTKGIEGITVMEQLRFEQDPREFLKTKGYEGVKQWLILPKYILFEAQGGYRRMIASHQETQKANSLILPENLVTLLYHARHYDEINHKVSFDYVNAHKEGFNDIFDFISDFGVRYILAPQHLEKIKVAYEKNKEVDLKEMIDAILSLLKFTLFGASVEFKFFDIKILKRYKSLTDIWEATIIYQSVTGLYERRVEVRKLWDGERL
>NC_022878.1|WP_010736477.1|327428_327557_-|hypothetical-protein
MSKKWLKVGIGLGLVAIGAVYLGKKTGLLEDDRHLYDEFESI
>NC_022878.1|WP_023519016.1|325687_327382_-|oleate-hydratase
MQKKKAIMIGAGIANMAAAVYLIQEGKWRGDQITFYSLDDHGSNDGAPVDTVTDEYWNKNHPLENQKGYVARGGRMLNYRTYVDLMDLLSRIPSATEPGMTAEEDTRDFDAKHPTFDKARLLEGGKGIVDGGKLGFNNKDRVLLTKLIAMPDSEEEKLDNVTIAEYFKDDPHFFETNFWFMWETTFAFRTRSSAQELRRYMHQMIYEFTQIEHLVGVNRTRYNQYESIMLPLINYLKEQGCKIILNRRVVDWEFKETAMQDEITVTGLKMINTKTQEEEHVVVDGDTGVLFTNGSITDSATLGDYETPAEENMDYGAASSLWKKASEKFYNLGNPDKFFADRDASEWVSFTLTTKNHVLLNEITRITTQEPGNALNSFISTTPITPLGQKDVNMSIVVHHQPHFTSQKPNETVIWGYFLYPRRRGEFVDKEYIKMNGKEMLEELLGQLSKVDPGPVNIREKETEIYDSVINNIPVYMPYASALFNNRAKSDRPKVIPKHSTNLAFTGEFVEQPYQMIFTEQSAVRSGEIAAFHFTGIPMSRLVKTPRYDKDIPTLMRAAKKMFD
>NC_022878.1|WP_148294486.1|324789_325593_+|hypothetical-protein
MCTVWLFFLSIGGLFYTSLANEGFMNEQIKQANYIQKVTKEINGRVQSYHQEARVTPEVLADSISEELVKNNIEHFVKETYRDKQPSLIQETELEEHIKETIHTYKTEHEINIEEGIAGEELALHMIGGIFERSVQPSYLHLFIRGINDLSHQVLHYAWGIVSVSLLILAGFIYFNPGSIRSRIKKFACSLMGAGLISLAFAATLYYAQILQTEEQMESLQGLMRIYLTNFTLIVLLIGGSEIVVGGFAWLLAKRENKKRTVGQNQK
>NC_022878.1|WP_023519014.1|323368_324502_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MKAVTWQGKQKMEIRNVDDPKILAPTDAIIRITATAICGSDLHLYHHGESVMEKGYVVGHEPMGIVEEVGSEVKKLKKGQRVVIPFNISCGHCHFCTNHMESQCDNSNQEELYGGLFGFGKLNGNHWGGQAEYLRVPFADSTSFIVPDNDLPDEKVLFLSDILPTAYWSVANAGVKKDDTVVVLGSGPVGLFAQKFAVMAGAKRVIAVDPVKHRLDKAVRYNQIETYLLDDVNQAGDDLYELAHGGADVIIDCVGMDGLEPTKEKAKNLVSLQSGTISPIQMAAKAVKKFGTVQITGVYMTPASSYPLQEFFMRNIDVKHGQAPVVHLMPKIYDMIAEGLFDPTQIITHSMPLEEAARAYEIFDKKEDKNIKVVLKP
>NC_022878.1|WP_010736481.1|323014_323341_-|YrhK-family-protein
MPRIKRNTHDVEIGKEEDIEIRGRRFRLYFQNRYTLISLAVDLLTGIFYVLGSIALLTKIPDYYSNYLYLAGAIFLTTRPILRIVRNVFIYDEKKQRREQAKKEKHEI
>NC_022878.1|WP_175401355.1|322534_322993_+|GNAT-family-N-acetyltransferase
MYQWIKLNEHPELLEETASWFSSKWGIPAEVYAESIRTGIIEKESIPQWYVILDEKGAIVGGAGVIENDFHDRPDLAPNLCTLYVEPEHRNQGLAKWILEQTREEMHRLGFKKLYLMTDHTSFYERYDCSFLTMVKEEGGTTARLYQITTTT
>NC_022878.1|WP_010736474.1|334419_334782_+|DUF1622-domain-containing-protein
MFSETLVHLLEWVTAILNIFSILVLLVGIFLVLKNLMLERPLIKDYATRNRRNADIRKLLASYILLSLEVLIVADLIESVIKPTWTDILKLALIIIIRTIISYFLNLEIASHVSHERREV
>NC_022878.1|WP_019724648.1|334781_335138_+|DUF1622-domain-containing-protein
MEISWMTLLYPYLEWLVLILDIFAIVVLLWGGFLSIKDFLKDSLNPSFKQNERIHQNNGIKKMLGGYILLSLEILISAGIIESIIKPTLQDIFQLAALVVIRTIISYFLNKEIGPADV
>NC_022878.1|WP_023519021.1|335365_336796_-|hypothetical-protein
MIEHYLEKNLLRQLFLCGQFYVNKEVHLPTTATLLHVCQTTLLNDIKSLSRELSDQIIYQSKEKETYSLYFAPTTSRFQLMQRLSRPSLFLKTCLLYLEDEPDYIQLTELEFVSVSKAYALKKQVLDYFQACDIAIEHHSPHFTDIERRLVLLNVSYRTGTLPDLSLPCSFDVQAQEFIQAVTKKSGRIYDRDTQEILQTGFLISLFYQKDAPLSIDQSFIDEIKKRPIYHFVLAAWEESPFKQFFQPNEFYFILILFNLCDYGFDSYEAIEQDFAQLHQVFIENNPETKQLIQQFEQHFDHAFLGNKAFERALIRILRSAWKNYQLFLPEKFHLLTDEQRELFEEVKRIVSDWSHALPYQLKINPNCLRSFVIELTGILRLDKQKLTVRIVTNSDIKYLIYREALEAVTTCDISVEPMIYKQLSKEAIDFVAASSNRLLCERTLYTPVALSMEQIIPISVETVEQAIILLVKSSS
>NC_022878.1|WP_023519022.1|337294_339130_+|tyrosine-decarboxylase
MKDMDIKAVFIGDKAENGQVYKMLLNKMVDEHLGWRENYLPADLPAISEADKSTTSYLATRQHMMEVLDEVSERMRAGSIPWHSAGRYWGQMNAETLMPALLAYHFAMLWNPNNVALESSMATSQMEAEIGEDFAKLFSMPNGWGHLTADGSIANLEGLWYARCIKSIPLAVKETYPEKVKDLSDWELLNLSVEEILEMIETFTDEELDRVKAASSRSGKHIQELGKWLVPQTKHYSWMKALDICGVGLDQMIAIPVDDCYRMDVQVLEKTIRELAIQHIPILGVVAVVGTTEEGQVDRVDQIVELREKLKDEGIYFYLHVDAAYGGYARCLFMNEAYEFVPYASLAEFYEEHHVFHHEVKIERSVYEGFKAISEAESVTVDPHKMGYVPYAAGGITIKHKSMRNIISYFAPYVFEKSVKAPDMLGAYILEGSKAGATAAAVWTAHRVLPLNVTGYGQLIGASIEAAQRFREFLDQLSFTVNGKTIEVYPLNHPDFNMVDWAFKVQGCTDLKEINRLNEEMFDVSSYMEGDVYAERFITSHTTFTQADYGDSPVAFVESMGVPKEEWQKEQQVTLLRAAIMTPYLTDDNIFAYYTEAIKHAMEEKLREVLA
>NC_022878.1|WP_023519023.1|339157_340612_+|amino-acid-permease
MTDSKSTKQLSTLTFIGMTCALVASVRNIPDVAATGWTMLFYMLVAVLFYAFPISLISGEFAGMFPQKGGPELWVSQSLGRKWGFVVSWLLWVQMFPGMVMVASALAPLFGNMVNNVPLGLNSKFTLLVILVVYWIITLLNLKFDMAKIGGKIGVWLGLYVPLALMLLLGAAAWIKIGIMPNGTLGKFSWDLLVPDPSTAKSFVYFAPIMFIFTGIEMSSVYITRLAHPVKTYIRGIFAALVFLFVVNTLNALVVANVVPKGQMELNNIAQSISIDCQILGLSHMIVNLFSLLVFVGVAVQLSAWASGPAKTVTESARKGAYPPRFNFWKTNEFDVSKAVILTQSIIISVFALFYLLIPGVNQAFLMLVNATTVIYCIVYLIMGVAFLRFRKTNPTIPRPFRIGKKEGNGNLGAWLVVLVLFAAIVFSVGLTLKAGTWINFVAVALISGILFVAPLCIEKIRKPSWEQEIKNKLSEQKSTKQSE
>NC_022878.1|WP_023519024.1|340765_343315_+|HAD-IC-family-P-type-ATPase
MTWYKETAEETMNKLKTTKDGLSNQERTSRLEIQGRNEIEVKKKVSPLRKFLKHFTDLLMIILMVASVLKFLTGDYIEGSIILLVVIINSFVGYWQERKAEESLNGLKSLMSQDAVVLSEGVKKSIPATEIVQGDIVSLTAGDVVPADIRLVETYGLMIEEAALTGESDAVEKISEPLVDELGAGDQLNMAFSGTLVQAGSALGVVVETGNTTEIGKINQALQSVQQQTTPLVRKIHQLNKQIFRGIVFLSLFLIFFTSFRYGLEWNFLFSTIIALIVSMIPEGLPAVLTMILSLGVNEMAQEQAIIKGLPSVETLGSMTVICSDKTGTLTKNEMTVVETMTEDETRLLEIMKNCQEVQTKEDQVVETLSGNPTELALLRYTAEQNLPLKTSLAKLPFSSSYKYMATLHEEQDHAVVFVKGAPEVLLSRSSLSQSEQQQWINQASQLAKKGQRVLGFAYKQMPIEQELDHAQLQQLTFVGIAGIIDPPKESAIQAVRECQQAGISVKMITGDHKDTAQAIADQIGLKHTSNVLEGIDIDRLSDQDLAKKVSKVDVFARTTPEHKLRIVEALQKNGEIVGMTGDGVNDAPALKRADVGIAMGIKGSEVSKQAADMVLGDDNFHTIAKAVKEGRRILDNLQKTISFFLPTSLAQGLVIIWALLANQPLPLTPIQILWVNMVTTITLSYALGFEQASKDTMSRPPRDPNQGILTKYNVFRIFYVSLLIIIPAYWLAMQFEGQALQQTVLLQNIVAAQAVYMINCREQVDASLNKGFFQNKFLFISLGILFVLQTGVIYLPFAQQVIETTSLSFAQHLPILVNVLLLFTIVEVEKRISKTWIKRKEREAFAGN
>NC_022878.1|WP_010734358.1|343455_344751_-|ISL3-family-transposase
MNDSIKKMLRIIEKDLMITEVSYETLQKKKTLVVDAVLSPTPRACRSCGSTVVDGNGKAIIVKNGKKETIVRFEQYNHMPLVMRLKKQRYTCKNCRTHWTAQSYFVQSRHSIANHVRYKIASLLTEKVSLSFIAKSCQVSLTTVIRTLKEFKSYLPKQSKKILPRVLMVDEFRSHASIEDKMSFICADGETGKLIDVLPTRKLPRLTSYFLKCTNPEEVEFLVTDMNAAYFQLTKRVLPNAKIVIDRFHIVKHMNQAFNELRIREMNELRKAGQKSQAEKLKKNWRFLLKNRANINHYEYKTWKSFRAPKYPFLTEAMMIDRLLEFSTPLKEAYPFFHELVEAFRDKDPDLFFSLLAELPETLDDSFREKLQNLLTYEEGITNAMIYPYSNGKIEAKNTHIKTMKRVSYGFKSFENMRIRIFLINQLIKVR
>NC_022878.1|WP_010736466.1|345074_346517_-|helix-turn-helix-domain-containing-protein
MYSLMHQIITEKDLQRQVTLIELLLNHPKITVNELAEETNTTERTIFSDLQVIRSQLPDGWLIDSDQSGIRLLNQKNLLANDLWELFLKQSVSVQLIKELLFTKECSTTNFLAVNGLSYETLKRHTRKVNRQLLRYGLQIKLTKYTSTMSGSENAIRLFYHRLLMPFTHNNYFFEDYSIHESHYFRFLKRLKQTPFSVETEEIFGICWFFINTIRVKANCRIKDSFFKPEDTLYSTYATELTELYELEGVYLQKDELIFAFFCFLESWNYNNQYQEPVADILQSYPFSGKIKQFVQDLADTLHLEKLNETKLADNLILLLLKYHESPILIEQLNLQYHYFLEEYEQQYPQLYPFKQELLEQLKQELPIQEDEYFLRLLSFLIQQAILSVRPNKLNLYFFFQGEPSWKAFLQQELNDYFGKRVQLIPVELSQLSDITFHKNDLFVSNTPLDQVPIPIIYISTIPTKNELDQLTELTFRSYL
>NC_022878.1|WP_023519025.1|346633_347233_+|NUDIX-hydrolase
MATKIEQYKRLLAIAEAGLFYGKDPFDEERYQELKSIALSLLSNGEKEIEEQLAFILDQNEGYPTPKVDVRAFIKQENKILLVEDSHTKEWALPGGFAEIGYSPKENIGKEVKEETGLTVTVDQLLAIFDTNTRKDIPQAFQYYKVIFGCSIIGGSFITNNETSNSAFFALDDLPILSQKRTTEEQLAILAKGNLPYFE
>NC_022878.1|WP_023519026.1|347301_347754_+|MarR-family-transcriptional-regulator
MAEIIREIGAIARALDSISNIEFKEVALTRGQYLYLVRICENPGIIQEKIAEMLKVDRTTTARALKKLESNGLIRRVTDEQNKKNKRCYPTAQGEALYPMIIREHHYSTKVALAGLSEEEIQQLERLLTHVRKNISEDWNFVKKGNKRLY

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Crispr_ID: NC_022878_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022878_2

663418-663535

TypeV

Consensus_repeat	Method
CAGTACGCCCCACCCCACAAGAACAGAAAACCAA	CRISPRCasFinder

1 spacers

cas14j

The CRISPR arrays of NC_022878_2

>merge|NC_022878|2|663418-663535|CRISPRCasFinder
CAGTACGCCCCACCCCACAAGAACAGAAAACCAACCTGTGGCTTTAAATCTTGTTGTGGAAACGACTAAACAACCAGAAGGAATCAGTACGCCCCACCCCACAAGGACAGAAAACCAA

>NC_022878|2|2|663418-663535|CRISPRCasFinder
CAGTACGCCCCACCCCACAAGAACAGAAAACCAA	CCTGTGGCTTTAAATCTTGTTGTGGAAACGACTAAACAACCAGAAGGAAT
CAGTACGCCCCACCCCACAAGGACAGAAAACCAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022878.1\|WP_019722498.1\|657533_658616_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NC_022878.1\|WP_010736142.1\|670932_672942_+\|methionine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237028
NC_022878.1\|WP_023519223.1\|677637_678522_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl\|CDD\|234708
NC_022878.1\|WP_051377631.1\|650363_650774_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_019722499.1\|656484_657528_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NC_022878.1\|WP_023519217.1\|659556_660564_+\|helix-turn-helix-domain-containing-protein	cas14j	-	gnl\|CDD\|223747
NC_022878.1\|WP_010736137.1\|677075_677645_+\|ribonuclease-M5	unknown	unknown	gnl\|CDD\|273019
NC_022878.1\|WP_023519221.1\|674085_674679_-\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_010736151.1\|658590_659544_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224048
NC_022878.1\|WP_010736144.1\|669463_670285_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|223979
NC_022878.1\|WP_010736158.1\|651323_652397_+\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|237717
NC_022878.1\|WP_023519222.1\|676306_677083_+\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|223162
NC_022878.1\|WP_010736139.1\|674847_676170_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|273332
NC_022878.1\|WP_019722490.1\|678773_679400_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_023519215.1\|652482_653025_+\|aminoglycoside-N-acetyltransferase-AAC(6')-Ii	unknown	unknown	gnl\|CDD\|366181
NC_022878.1\|WP_010736155.1\|655117_655462_-\|DUF3899-domain-containing-protein	unknown	unknown	gnl\|CDD\|372441
NC_022878.1\|WP_010736156.1\|653357_655025_+\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173869
NC_022878.1\|WP_023519216.1\|655542_656484_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NC_022878.1\|WP_010736145.1\|668886_669339_+\|IS200/IS605-family-transposase	unknown	unknown	gnl\|CDD\|376616
NC_022878.1\|WP_023519220.1\|673282_674044_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718

Protein	Function_ID	Function_description	E-value
NC_022878.1\|WP_019722498.1\|657533_658616_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	0
NC_022878.1\|WP_010736142.1\|670932_672942_+\|methionine--tRNA-ligase	gnl\|CDD\|237028	PRK12267, PRK12267, methionyl-tRNA synthetase; Reviewed.	0
NC_022878.1\|WP_023519223.1\|677637_678522_+\|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl\|CDD\|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	9.42887e-147
NC_022878.1\|WP_019722499.1\|656484_657528_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.48337e-92
NC_022878.1\|WP_023519217.1\|659556_660564_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.16706e-22
NC_022878.1\|WP_010736137.1\|677075_677645_+\|ribonuclease-M5	gnl\|CDD\|273019	TIGR00334, Ribonuclease_M5, ribonuclease M5. This family of orthologous proteins shows a weak but significant similarity to the central region of the DnaG-type DNA primase. The region of similarity is termed the Toprim (topoisomerase-primase) domain and is also shared by RecR, OLD family nucleases, and type IA and II topoisomerases. [Transcription, RNA processing].	2.51277e-56
NC_022878.1\|WP_010736151.1\|658590_659544_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	3.18777e-127
NC_022878.1\|WP_010736144.1\|669463_670285_-\|NUDIX-hydrolase	gnl\|CDD\|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	1.79715e-29
NC_022878.1\|WP_010736158.1\|651323_652397_+\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|237717	PRK14455, PRK14455, ribosomal RNA large subunit methyltransferase N; Provisional.	0
NC_022878.1\|WP_023519222.1\|676306_677083_+\|TatD-family-hydrolase	gnl\|CDD\|223162	COG0084, TatD, Mg-dependent DNase [DNA replication, recombination, and repair].	2.92124e-121
NC_022878.1\|WP_010736139.1\|674847_676170_+\|amino-acid-permease	gnl\|CDD\|273332	TIGR00911, High-affinity_methionine_permease, L-type amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.14964e-64
NC_022878.1\|WP_023519215.1\|652482_653025_+\|aminoglycoside-N-acetyltransferase-AAC(6')-Ii	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.619e-10
NC_022878.1\|WP_010736155.1\|655117_655462_-\|DUF3899-domain-containing-protein	gnl\|CDD\|372441	pfam13038, DUF3899, Domain of unknown function (DUF3899). Putative Tryptophanyl-tRNA synthetase.	0.000129088
NC_022878.1\|WP_010736156.1\|653357_655025_+\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173869	cd08504, PBP2_OppA, The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding component of an ATP-binding cassette (ABC)-type oligopeptide transport system comprised of 5 subunits. The transport system OppABCDEF contains two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NC_022878.1\|WP_023519216.1\|655542_656484_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.94998e-111
NC_022878.1\|WP_010736145.1\|668886_669339_+\|IS200/IS605-family-transposase	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	1.08792e-44
NC_022878.1\|WP_023519220.1\|673282_674044_+\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	3.25461e-21

>NC_022878.1|WP_023519217.1|659556_660564_+|helix-turn-helix-domain-containing-protein
MLKAFKFRIYPTDSQKQWLIQTFGCVRFTYNHLLKARQAYYLETQAIDYTLTPASLKKQYPFLKEVDSLALANAQLNLDRAFRNYFKGRASFPKLKNKKSIWQSYTTNNQKGTIYLEETYLKLPKLKEKIRIHAHRPIEGTIRSATISSRYNEIFYVSLLCEVPQKTMKASNKWIGIAYDPDRLVEMSTPLDITIPKFKQVDQQLLRAKRKLVIKGRSAQHRRTRVERVKNYQKQKRKIKDLYLKQKFQREDYLEQISGTVIRHYDYLFVESISADCPEGDFSIQDWHKLLAKLQYKSQWYSKKLVLIDMKEQTDPSTNKKSLELVEIGKQVLFE
>NC_022878.1|WP_010736151.1|658590_659544_+|ABC-transporter-ATP-binding-protein
MNKKLLEVKGLKQYFNVGKKNEVHAVNDISFHIYEGETFGLVGESGSGKSTTGRTIIRLNEPTGGEILFDGQDVTKLKGKQAMTKFRHEVQMIFQDPYASLNPRMKVRDIIAEGIDVNGLAKSPEERAEKVNELLKTVGLNPSHGTRYPHEFSGGQRQRIGIARALAVNPKFIICDEPISALDVSIQAQVVNLLQDLQKEQGLTYLFIAHDLSMVKHISDRIGVMHNGLLLEMGTSEEIYNHGVHPYTESLLSAIPLPDPDHERQRRRIKYQPEPDDGQIRTLREIAPEHFVYATEQEVAYYAKKLKRQKEALLVAN
>NC_022878.1|WP_019722498.1|657533_658616_+|ABC-transporter-ATP-binding-protein
MTKILEVKNLQISFDTYAGKVQAIRGVDFHLNKGETLAIVGESGSGKSVTTRSIMRLLSSNASIDSGEILFKGQNIVDKTEKEMQKIRGKEIAMIFQDPMTSLDPTMTIGKQVAESLRKHNKVSKKEGQKAALELLNLVGIPEAEKRIHSYPHQFSGGQRQRIVIAIALICYPEILIADEPTTALDVTIQAQILELLKKIQSKIDTSIIFITHDLGVVANVADRVAVMYGGKIIEVGTSEEIFYNPQHPYTWGLLGSMPTLESGNDRLYAIPGSPPDLLNPPKGDAFYPRNEFALKIDAEQAPPFFELSPTHQAATWLLAPQAPKVTPPEEIQRRWAIFQEKQKAHGQGGLNNEQKTARG
>NC_022878.1|WP_019722499.1|656484_657528_+|ABC-transporter-permease
MELIPKRYETIAEIPADEFLPLQKNTEEEREKIEAPSLNFIQDSWRRLKKNKAAVISMGLLIVIIFISIITIFVSPHDPTAQNVDYINLPPRIPGINIDGLNGKAMVAGELVDKYAQANVPADVNYFLGTDGLGRDVLSRLFMGTRISLLIAFIAALLDVTIGVAYGLISGLLGGRVDNAMQRFLEVLSGIPNLVVMILMLVVFEPGIFSIVAAMAITNWIPMARIVRAQTLKLKDQEYVLAGMTLGESKWKIAFKHILPNISSVIIIQMMFSIPSAIFFEAFLSFIGLGLTPPSASLGTMLSDGYKTFLYLPYLLWIPAATLSVIMIGFNLLADGLRDAFDPKMKE
>NC_022878.1|WP_023519216.1|655542_656484_+|ABC-transporter-permease
MNSYIKYVLKRVFFMVITLWLIATITFFLMQLLPGTPYTNQERLSPETIEMLNKQVGLDKPVIVQYGIYLSNLLQGDFGISFQFKNQPVANLLAGRVGPSLQLGLQAIIFGTFFGTILGTISAMKQNTWVDTSSTLVAILGRSIPNFVFAVLLQYIFAIQFRVLPIAKWDGFMYTILPTIALAMSPLADSARFIRTEMVEVLHSDYVELARAKGLSRWEIAFKHGLRNSLIPLMTLLGPLAVALMTGSLVVENIFAIPGIGEQFVKSITTNDYPTIMAVTILYSFMLILVILVVDLLYGLVDPRIRVSEGSRS
>NC_022878.1|WP_010736155.1|655117_655462_-|DUF3899-domain-containing-protein
MKKKYRPYLFAGLVIVLVLLKNALTDQLTLLQLSNDLFLCALPFLIIGGFLWVFSSGFFDHFQRSFHLARTRNRKEKPEFTSLSSVSYGMYTFWLIIAGILLVFSIVFALISLV
>NC_022878.1|WP_010736156.1|653357_655025_+|peptide-ABC-transporter-substrate-binding-protein
MKKNLTFGVVALCGLVLAGCYGGSSADTSGSGSSSSGSADGGGVFNLVVPQEMPSADLSVATDTISFTALNNVYEGIYRLDEDSKPQPAGASELAEVSEDGLTYKVKLREDAKWSNGEPVTAADYVYGWQRTVDPATASEYAYLFAPVENAEAITAGDKDKSELGIKAVGDYELEIKLAKQTPYFQYLLAFPSFFPQSQAVVEEHGDAYASSSDNAVYNGPFTLADFDGPGTDTEWTYKKNEEYWDKDAVKLSEIKVSVVKESSTALNLFKDGQADDVILSGELAQQNANDPAYTSVKEARTSYIEFNQREDDSPFKNVNLRKAISYSINREALVKQVMGDGSVVSTGLIPADMTKNPETNEDFAAEAGELVSYDQDKAKEYWEKAKSELGIDSLEFELMASDDDSTKKVIEYIQNSIQENLDGVKVKPTPVPFSVRLDRSSSGDFDTVLGGWGADYADPSSFTDLFVTGNSYNRGQWSNADYDKAVEASASKDAGDEQARWADLQEANKIIAEDMGVAPVYQKAEGHLVNPKVKGIVHHAAGASWDYKWTYIEE
>NC_022878.1|WP_023519215.1|652482_653025_+|aminoglycoside-N-acetyltransferase-AAC(6')-Ii
MIISEFDRRNIGLKDQLADLLRLTWPKDYGEQPMKEVEQLLAMDRIAVSAVEQDRLVGFIGAIPQYGMTGWEIHPLVVETSYRKQYIGSRLVAYVEKEIASKGGVMVYLGTDDTDGDTSLSHTDLFDHPLDKLKSIETFNKHPYTFYEKMGYQVVGAIPDANGLNQPDIILAKRLGEINQ
>NC_022878.1|WP_010736158.1|651323_652397_+|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MEKQSIYGLTNKELTAWFLEHGEKKFRASQVWEWLYQKRVTSFEEMTNLSKSLIEKLSENFEINPLKQVIVQEASDGTVKYLFELPDKNMIETVLMRQEYGLSVCVTTQVGCNIGCTFCASGLLTKNRDLTAGEIVAQIMMVQHYFDERQLGERVSHVVVMGIGEPFDNYDNVMDFLHIINDAKGLAIGARHITVSTSGLANKIKEFAENGLQVNLAISLHAPNNEVRTSMMRINRRFPIEKLMEAVDEYLEKTNRRITFEYIMLNQVNDRPEHAQQLADLLKDKKKLTYVNLIPYNPVSEHDQYSRSPKADVLKFYDVLKKNGINCVIRKEHGTDIDAACGQLRSKQMKKEKTVAK
>NC_022878.1|WP_051377631.1|650363_650774_+|hypothetical-protein
MANSEFQRGNQEVPEEIKKWNWGAFSLNIIWGIGNKTYLPLLCLIPLFNFVWVFICGFKGNEGAWRDGNYTDVETFKQVQKTWSRAGIAMFIIQIVIILLYLVFVVFILSSLWYIRDSFIRDSYNYDPYIYDGYYY
>NC_022878.1|WP_010736145.1|668886_669339_+|IS200/IS605-family-transposase
MSNNDKSLAHTRWNCKYHIVFIPKYRRKVIYGKLRVSIGQILRKLCEMKDVEIIGAHAMPDHIHMLVRIPPKISISSFMGYLKGRSATLIHEKHANLKYKYGNKSFWSKGYYVSTVGLNQKTIEKYIREQEADDRIRDSISKQEYVDPFK
>NC_022878.1|WP_010736144.1|669463_670285_-|NUDIX-hydrolase
MEHFHSKEEEKTYYEQEASETDFLSWYQDQERPEYEKPSLTVDIVLLCYNKEEDQLKVLLIQRKSHPYRNSWALPGGFVQKNESTGASVLRETKEETGVIISEENIEQLHTFSTPNRDPRGWVVTVSYLAFIGEEPLIAGDDAKEVQWFSLERNANKLHLSSGDVAITLDLTTSESSGKDTLAFDHSEIIVKAFNRVVNKMEHEPQVLQVLGKDFTITEARKVFAKFLGIDFKMIDHSNFKKAMLQYFDEIGERPVGIGRPSKIYQLKPGHTE
>NC_022878.1|WP_010736142.1|670932_672942_+|methionine--tRNA-ligase
MAEKETFYITTPIYYPSGKLHIGNSYTTIACDAVARYKRLMGFDVFYLTGVDEHGQKIEKKAEELGVEPQEYVDKMAADVKKLWKTLDISYDKFIRTTDDYHKAAVQKIFDRLLEQGDIYLGEYEGWYSVSDEEFFTETQLAEVYKDEDGKVIGGKAPSGHEVELVKEESYFFRMSKYADRLLEYYEEHPEFIQPESRKNEMINNFIKPGLEDLAVSRTTFSWGINVKNDPKHVVYVWIDALSNYITALGYGSEDDQLFQKYWPADVHMVGKEIVRFHTIYWPIMLMALDIPLPKKVFGHGWLLMKDGKMSKSKGNVVYPEMLVERYGLDALRYYLLRAVPFGSDGVFTPEDFVSRVNYDLANDLGNLLNRTIAMINKYCDGMVPDYASLVTPFDSELSTTAANVVGRYHDAMEKMEFNTALAEIWVLISRANKYIDETEPWVLAKDEEKKKELESVMIHLAESLRITAILLQPIMTETPTKIFNQLGLDAETMNLEGLHFGEFPSGTKVVAKGTPIFPRLELEEEIAYIQAKMSEGTQTNEDSVKWDPEETELVSTKEKQIKFDVFEKVELKVAEVINCQKVEGADKLLQFRLDAGDDQDRQILSGIAEFYPDPSELIGKKLVIVANLKPRKMRGLISQGMILSAEAADGSLQVIEAPKGMPNGSEVG
>NC_022878.1|WP_023519220.1|673282_674044_+|Fic-family-protein
MNVAELDLVTRFVLEKKANLHGGIYHLTQVEMAYNSNRIEGSRISEKQTALIFENNILPPAESGEATKLDDIKETENHFKGFDYVIDHIEEPLSNDFIKELHRILKRGTTDENNPLTPVGEFKLVQNMIGFGYDEVETIASEEVTEKMTELLAHYENSKKQSLVEIADFHVKYERIHPFADGNGRMGRLMMFKECLRHNIMPFVIKVVHREFYYRGLSNWGTENGYLLDTLGMSQDMYEQFLKKMKFTGSVHQ
>NC_022878.1|WP_023519221.1|674085_674679_-|hypothetical-protein
MDFQSIDPKLASYLKDKGTTFFPQKEQKQSKLHWLLLILFGWLTIATLTQQLLLMASFLLIAALIKGPGMLLWGIVYSFLVGLFPPIAFLLSVIFLLLNVQTIVKNWRVTMVGIFFYGYPLTMNALRHLTDWDTRWFFAISLLLGLVILHSLLTKIYVRYGNSRLIAWYILCIPFSIVAALLPTKVKQRLKLKKVGR
>NC_022878.1|WP_010736139.1|674847_676170_+|amino-acid-permease
MKGKLKREINLFGALSTVMGTVIGAGVFFKTAAVVASTQSTSLTLLAWLLGGFLTICAGLTVAELATAIPETGGAVKYIEAAYGKLPSFLLGWAQSLIYFPANIAALSIIFATQLINLLQLSPDYLLVIAIITALSITGLNLLGTKVGAYVQSITLVVKLIPIAVIIIWGLLTPGQGTVQLFPVEAGQGVSWAEGLSGALLATLFAYDGWLGVGAMAGEMKRPEKDLPKAIILGLSFVTFVYLLINFVFLKTLPIDQIAGNLNASSDASAVIFGELGGKIVTIGILISVYGALNGYTLTGIRVPYAMALENELPFSNQLTKLSKKFTVPYVPALFQLAIACIMMSLGSFDFLTDMLIFVMWLFSLLIFIGVFILRKKAPEMPRPYKVPLYPVIPIIAILGAIFILGMTLITQTNLALIGILVTLLGVPVFYYKKRQTESN
>NC_022878.1|WP_023519222.1|676306_677083_+|TatD-family-hydrolase
MIFDSHTHLNAEQFNDDIPETIQRAEELGVTKMAVVGFDTPTIEKSLMLSQDYPNIYSIIGWHPTEAGSYTKEIENKLQEQLTLPKVVALGEIGLDYYWMEDPKEVQDKIFRRQIAIAKEMRLPISIHTRDALEDTYKVLKEEDIRDIGGIMHSFSGDYEWAQRFLDLGMHISFSGVVTFKKALDVQEAATNVPMDRLLVETDAPYLAPVPYRGKRNEPGYTRYTVEKIAELRQLPMEEVAAQTWKNAHHLFGLSEHD
>NC_022878.1|WP_010736137.1|677075_677645_+|ribonuclease-M5
MTKLKIQEIIVVEGKDDTRRLQEVVEADTIETIGSAINEEILMQIEHAQETRGIIIFTDPDFSGEKIRKTIMEVVPQAKHAFLPRNQAVPKKKGSLGVEHASDEAILEALKKVVTPVDDETQVPEITRQMLVAYGLIAGAHAKEKREMLGDELRIGYTNGKQLEKRLNMFRITLTEFKQAMKKVEDHYE
>NC_022878.1|WP_023519223.1|677637_678522_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MSEYRDIATPTRTKEILLKHGFSFKKSLGQNFLTEPNILRKIIETGQIDQQTNVIEVGPGIGALTEQIARHAKQVVAFEIDDRLIPVLADTLSPYPNVTVIHQDILKTDLAEAVNTQFNERLPLKVVANLPYYITTPIMMHFLESEVVVDEMIVMMQKEVADRISAKPGTKAYGSLSIAVQYYMEASLAFIVPKTVFVPQPNVDSAILKLTRRAIPAVSVTDEKAFFRLTKAAFQQRRKTLWNNLQHAYGKDEETKSWLTASLTEAGIDPKRRGETLSLEEFAALSNAMEHLKK
>NC_022878.1|WP_019722490.1|678773_679400_+|hypothetical-protein
MKTNSVRKLTISALLIGMGVLIPMIMPKIVIPPASFTLASHVPLFIAMFFSPGVAVAVALGTTFGFFLTTPVIIALRALSHLVFALIGAWYLQKKPGIVLKDGQFTLMNWRFQGFNLLIGVIHSIIEMLVVSVFFFIGNMPETYYAEGYFYTVFILMGIGGLIHSLVDYNIAYFIAGTLSKFFDVPVFTAAKKQQKKEIVQGTIKKVV

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Crispr_ID: NC_022878_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022878_3

821457-821531

Orphan

Consensus_repeat	Method
GGAGTAAATCAAATGAAAGTAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022878_3

>merge|NC_022878|3|821457-821531|CRISPRCasFinder
GGAGTAAATCAAATGAAAGTAAATGAAGCGTTAGAGTTATTGCGATGGATGCGGAGTAAATCAAATGAAACTAAA

>NC_022878|3|3|821457-821531|CRISPRCasFinder
GGAGTAAATCAAATGAAAGTAAA	TGAAGCGTTAGAGTTATTGCGATGGATGC
GGAGTAAATCAAATGAAACTAAA

Protein	Signature genes	Signature genes Name	Protein_function
NC_022878.1\|WP_023519307.1\|819935_820511_+\|DUF1642-domain-containing-protein	unknown	unknown	gnl\|CDD\|369557
NC_022878.1\|WP_023519305.1\|818655_819714_+\|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl\|CDD\|273211
NC_022878.1\|WP_023519317.1\|824679_825144_+\|phage-terminase-small-subunit-P27-family	unknown	unknown	gnl\|CDD\|377461
NC_022878.1\|WP_023519306.1\|819727_819943_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_023519318.1\|825182_826925_+\|terminase-large-subunit	unknown	unknown	gnl\|CDD\|226974
NC_022878.1\|WP_023519313.1\|822497_823568_+\|DUF4062-domain-containing-protein	unknown	unknown	gnl\|CDD\|379095
NC_022878.1\|WP_023519310.1\|821071_821269_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_041684392.1\|828337_828955_+\|HK97-family-phage-prohead-protease	unknown	unknown	gnl\|CDD\|309640
NC_022878.1\|WP_023519304.1\|818263_818659_+\|YopX-superfamily-protein	unknown	unknown	gnl\|CDD\|370597
NC_022878.1\|WP_023519308.1\|820507_820729_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_051377632.1\|823951_824194_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_023519301.1\|817745_817934_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_023519300.1\|817173_817746_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_023519316.1\|824180_824522_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|366837
NC_022878.1\|WP_023519322.1\|829012_830227_+\|phage-major-capsid-protein	unknown	unknown	gnl\|CDD\|273690
NC_022878.1\|WP_023519302.1\|817944_818139_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_023519309.1\|820725_821082_+\|hypothetical-protein	unknown	unknown	unknown
NC_022878.1\|WP_023519312.1\|821813_822290_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180707
NC_022878.1\|WP_023519320.1\|827136_828399_+\|phage-portal-protein	unknown	unknown	gnl\|CDD\|273677
NC_022878.1\|WP_023519323.1\|830244_830538_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_022878.1\|WP_023519304.1\|818263_818659_+\|YopX-superfamily-protein	gnl\|CDD\|370597	pfam09643, YopX, YopX protein. YopX is a protein that is largely helical, with three identical chains probably complexing into a twelve-chain structure.	8.60409e-17
NC_022878.1\|WP_023519307.1\|819935_820511_+\|DUF1642-domain-containing-protein	gnl\|CDD\|369557	pfam07852, DUF1642, Protein of unknown function (DUF1642). The sequences making up this family are derived from various hypothetical phage and prophage proteins. The region in question is approximately 140 amino acids long.	2.06041e-30
NC_022878.1\|WP_023519305.1\|818655_819714_+\|DNA-(cytosine-5-)-methyltransferase	gnl\|CDD\|273211	TIGR00675, Modification_methylase, DNA-methyltransferase (dcm). All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	4.3328e-94
NC_022878.1\|WP_023519317.1\|824679_825144_+\|phage-terminase-small-subunit-P27-family	gnl\|CDD\|377461	pfam05119, Terminase_4, Phage terminase, small subunit.	1.82904e-24
NC_022878.1\|WP_023519316.1\|824180_824522_+\|HNH-endonuclease	gnl\|CDD\|366837	pfam01844, HNH, HNH endonuclease. His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.	1.72154e-07
NC_022878.1\|WP_023519322.1\|829012_830227_+\|phage-major-capsid-protein	gnl\|CDD\|273690	TIGR01554, prophage_Lp3_protein_18, phage major capsid protein, HK97 family. This model family represents the major capsid protein component of the heads (capsids) of bacteriophage HK97, phi-105, P27, and related phage. This model represents one of several analogous families lacking detectable sequence similarity. The gene encoding this component is typically located in an operon encoding the small and large terminase subunits, the portal protein and the prohead or maturation protease. [Mobile and extrachromosomal element functions, Prophage functions].	5.31455e-45
NC_022878.1\|WP_023519318.1\|825182_826925_+\|terminase-large-subunit	gnl\|CDD\|226974	COG4626, COG4626, Phage terminase-like protein, large subunit [General function prediction only].	3.65697e-84
NC_022878.1\|WP_023519320.1\|827136_828399_+\|phage-portal-protein	gnl\|CDD\|273677	TIGR01537, portal_protein, phage portal protein, HK97 family. This model represents one of several distantly related families of phage portal protein. This protein forms a hole, or portal, that enables DNA passage during packaging and ejection. It also forms the junction between the phage head (capsid) and the tail proteins. It functions as a dodecamer of a single polypeptide of average mol. wt. of 40-90 KDa. [Mobile and extrachromosomal element functions, Prophage functions].	8.28553e-70
NC_022878.1\|WP_023519312.1\|821813_822290_+\|hypothetical-protein	gnl\|CDD\|180707	PRK06811, PRK06811, RNA polymerase factor sigma-70; Validated.	2.86695e-06
NC_022878.1\|WP_041684392.1\|828337_828955_+\|HK97-family-phage-prohead-protease	gnl\|CDD\|309640	pfam04586, Peptidase_S78, Caudovirus prohead serine protease. Family of Caudovirus prohead serine proteases also found in a number of bacteria possibly as the result of horizontal transfer.	7.39266e-47
NC_022878.1\|WP_023519313.1\|822497_823568_+\|DUF4062-domain-containing-protein	gnl\|CDD\|379095	pfam13271, DUF4062, Domain of unknown function (DUF4062). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.	1.06242e-34

>NC_022878.1|WP_023519310.1|821071_821269_+|hypothetical-protein
MNYKVGWWKKGEQYRYCLGMGLDGLVYYRTKRQALGNSRCITGIHPDFDKWFKKAEYVGLELEEA
>NC_022878.1|WP_023519309.1|820725_821082_+|hypothetical-protein
MSELVKEIERQLGNDMIEEGNMTAYDVLEIIKNFKQPKLNENQQNLIIWMKENECETNDPLESISDLFLNGTPSKYFPDSPLSCLEAAYQSLNNQQKMELVSEYLKQYSEQEENSNEL
>NC_022878.1|WP_023519308.1|820507_820729_+|hypothetical-protein
MNIENTALPESGYLEKVINVERLQNGNFQVMVRAFPTRKRKVQTIKMEFSQNGFNALVGSLMAMAQAEEVAEG
>NC_022878.1|WP_023519307.1|819935_820511_+|DUF1642-domain-containing-protein
MNKQELIDKLASLVGSMEDFKGITAFHDGKYAGLEHALELIQQLDEPQKPVVPKFVAEWLEKMRKQLVSYHFESGARFMMFIGIDYHQRRGLLTLNEKVRRWLEKDGNEVKLSNAIDYGYEVEQEPLYYVYFPEITASAGIGEAYLMKTRNGVELADNNDFDDMKFTEQEIKTIDERYWAFAVPVEEVMEG
>NC_022878.1|WP_023519306.1|819727_819943_+|hypothetical-protein
MNLKILQKKSLGRETEAMLLSVEDGEVYQVSICITRIEKPYYANQLYRIFAKLDEAQEFYNKLCEMREQDE
>NC_022878.1|WP_023519305.1|818655_819714_+|DNA-(cytosine-5-)-methyltransferase
MRFLDLFAGIGGFRLGMEFAGHECIGFCEIDKFARASYKAIHDTEGEVEMHDITTVSDEFVRGIGSVDVICGGFPCQAFSIAGKRKGFEDTRGTLFFEIARFASILRPRYLFLENVKGLLNHEGGATFETIIRALDELGYDVEWQVLNSKDYVPQNRERVFIIGHLRGERTRKVFPFSGNDEPLVELQRQQSSVNIITARYGDASGVGSYVIESKQQKQVAIPVLTPDRLEKRQNGRRFKNDGDEMFTLTAQDRHGIMVAGKLPGNHDQNSRVYNSGGIAPTLSTMQGGGQEPKIWIDYQIRKLTPRECWRLQGFPDWAFDRAKQVNSDSQLYKQAGNSVTVPVIADIAKRL
>NC_022878.1|WP_023519304.1|818263_818659_+|YopX-superfamily-protein
MIPKFRALNIKTGFWFDEQELVFCDGKWFHNWRSFEDEFPLNMRDCVVMQSTGLKDKNGVEIFERDIIKNSNGLTGYVTYLQQEAGFVVVLKKSDYRLGHRNTGESYAEATNHEVIGNIYENPELLEEVKK
>NC_022878.1|WP_023519302.1|817944_818139_+|hypothetical-protein
MIQVAGIRTGKIYFTGKNKSEASQWLLKTFTNNKKLRKHYSNEFLKDDQIMPEPMILTTKEISK
>NC_022878.1|WP_023519301.1|817745_817934_+|hypothetical-protein
MRLKEYNIILENAKFTWTDEEIEHARLLFSQGVKPSVVAEIMDQKIIDVSLLLIHLINEKMI
>NC_022878.1|WP_023519300.1|817173_817746_+|hypothetical-protein
MTKQVNFRPELKKVTSKSNGNTEVLLVVSNGSLRGSTENLTEFLGSTVTVVIQPETIEYTVPVNKQTKKPNIEYVVHADGTTEIKKEEQTSLDVGDDVEEVENVKILVSKETIDEFIKKATTLQLPENVTVNIRDVLIRLEEGDNLNEIAADHELSETALIDQIELARQHFAPFADSWSKSKDDIIFPEE
>NC_022878.1|WP_023519312.1|821813_822290_+|hypothetical-protein
MRFQWLKDYQELDEQILYLKWNLNKSKLELTRWVSGDLASVRIEKNSRSSSLEENIQKIENELSLLQEQKEEILLIIDSFSGIDNQIIKMKYVDDMKLEDIAEELRYSESHIRKRHSEIRKTMKFLDEYELRQEERLKQENEIEYYNSEDCEQQLSLF
>NC_022878.1|WP_023519313.1|822497_823568_+|DUF4062-domain-containing-protein
MEKKYQIFISSTYLDLKEERQKVVEAVLSAGHIPAGMELFHAGDETQKELIEEWINDSDIYVLILGGRYGSLDSDGQSYTEWEYDKAKELNKPRFSLVLTKEYLDNKVHAGLINGTDLEYNTQNLVDFRDKVKSKIVSEINNIEQIEAEVFKAINRISSKQSENLEGWIKGSWLSEIERLKKENADLSSQLVSRQSEVIDMQKELSATKDNYVGEYNFSYVKKVLANKKIKSDILNEKLQELEEKKSSEGLSIEEQKSYEELSKFKSEELSALEYILKNKNKLLTDGLILYSNIVHDIFSSEIISVWNQLSLIDKVRIKPQVGSFLGNMYDKVTLNENGKKFISMIEIEQSNNAKA
>NC_022878.1|WP_051377632.1|823951_824194_+|hypothetical-protein
MDKIAETFSSIISAYGLSVMETCSLAYYLVDKALNTPQNKLMLQEKFFIDTDKLGVDGKLTIMKAMLSVYSKEVYGNDKT
>NC_022878.1|WP_023519316.1|824180_824522_+|HNH-endonuclease
MTRPKKLTFIDGKRVLIDYATRQDEYRADNKDRWRYQKEIKRFYNSAAWRKLSKQVLNEHYYVCRNCGNDAVLTDHIIPVKVDWDKRLDINNLQPLCEACHSIKTKKDREIFG
>NC_022878.1|WP_023519317.1|824679_825144_+|phage-terminase-small-subunit-P27-family
MGRKISLLDNNKKHLTKEEKASRKTAEKLSGDGFVAMQVTPPNHMNPIAKQEYKRVIEDIQKLPLRNLDRAILENYCVWYSIFKEASKKLNEHGSFIKKNDGTYEENPVIKTMEKATKNIKSTASELGLTVDSRLRLYLPKKEENKKTIFDKYG
>NC_022878.1|WP_023519318.1|825182_826925_+|terminase-large-subunit
MIDYQRIPNKLRDDTYAYAVLIVERKIISCKKVYDACIRHLKDLLKIPKLSWKYNYDPVEAAKAIEFLEMLPDVKTGKTYPLADFQRFIIGSIYGWRSKNNRTIRRFKKAFISVARKNGKTILIAGIVLYEFLFAKNPALSRQIFCTANDKKQASIAFDMARKQLDALRSKYPDIRKATKRVREFLKNLRDESYITVLSKETGAIDGFEPYIGVFDEYGASKTDEMMELIESGQGQLDNPLILIISTANFNLNVPMYRVEYPRMKDILEETLEDEEQFIYIAEQESIKELEQPEMYIKSNPILSVSALHEKMMTNLKKRWKAGKEKGTTIKIMVKNFNMWSQSSDEAYLSADHWKKALIDKPDIKGKKVWFGIDVGRTSDLFSISWVVHMGDYFYVDSFSFIATKYGLATKEKRDGISYTNLQMKNECKITDLESGVIDYDETYEWLEQFIYENDLDVQCIAFDPHQYGHILTLIEKNHPEWLQAEVRQTSLVLNMPTKQFRDDVINLKIRHSGNELLTAAIYNAITKVDNNGMRIDKNKNSNKIDPIDALLDAYAMCYTEFQSGGYWTDEKILGGDFGF
>NC_022878.1|WP_023519320.1|827136_828399_+|phage-portal-protein
MAFFQALGSKEAQIDALIYDSQTTSQSYTGIKALKNSDVLTAVMIIAGDIARFPIIKQDLDGRITQDEDLNYLMNVKSTKEATAHAWKFAMVVNAILCGNAYSRILRDPKTKKALEFEFYPPSAVSIVEGDDYTSRSYIFYPLQGNREIRCDPEDVIHWKFFSSDAVYGRSPLLSLRNEISLQESGISTLLKFFRDGFSSGILTMKGSQLSGEARKSVRQEFEISREGATGGSPIVMDSTMEYTPLEIDTNVLSLINSNNYSTAQIAKCLRVPAHKLAITNPNQSVKQLNDDYILNDLPYYFNAITSEFQLKLLEQKERKKFILNFDTRSVTGLMPEDVMRLYNGGLVTGDQALNLMGISASGDPDMQRRKFSLNYVWSDLAEKYQLDQNNKRKRKGDDYDEQSGDSSENDQTRIEKVGE
>NC_022878.1|WP_041684392.1|828337_828955_+|HK97-family-phage-prohead-protease
MNKAEIRQRTTKLELRKLENEVEVIEGYALKFDRWSDTLGWYYPFREKLEPGCLDEADTNNVVALFNHDQSQILGRTGANLELNIDNIGLKFRIIPTNTTLSKDLIENIRSGVINQCSFAFTIPDQEGAESWRENKETGIYERLVHKIDHLYDVSVVTTPAYPDTEAVVGERSKQMVEELHKHPRKHEARRMLFDLEKEELLKIL
>NC_022878.1|WP_023519322.1|829012_830227_+|phage-major-capsid-protein
MFEEKIKELRDKIIAGEAEQEQLATEMRSLLEGDASEEKIKEAKAKKVKRDLAKAELTELRETLALYEEQKKGNSKKVEGGTRGTSQDQEYREALNTFIRTKGAQTDGLTMIEKDEALVPERFWRANDSAVDGIIKEDTKAVTSEEISYIPAREIQTVVNLKLFARIHKAKKGSGKYPILKRATTRMYSVEELEKNPKLTKPDFDHVDWSVVTYRGAIPLSQESIDDADVDLVNLVAENNTEISLNTTNYAMSEVFKKFPKKTISGLDDIKKIYNVDLDPAYRKVFVASQSFYNFLDTIKDGNGRYMLQDSILSASGKTFGGYPFFVVGDELLGEAGQANAFLGDPKRGILFADRKQLAVRWANHEIHGQYLQAVLRFDVQIADKKAGFFLSYDGGKAEEVPKP
>NC_022878.1|WP_023519323.1|830244_830538_+|hypothetical-protein
MKIRILKNVRLDFEGKVKEYPSSNQVLQIDDQLALEKDYLARYKKYPKHIEIVEEPKIKVNEQKNEGKQTEGIKASSKTESNKKGNKKRKTNKDVTE

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Crispr_ID: NC_022878_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022878_4

1932713-1932795

Orphan

Consensus_repeat	Method
CCTGGATCAGTAGTTTCTCCGCCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_022878_4

>merge|NC_022878|4|1932713-1932795|CRISPRCasFinder
CCTGGATCAGTAGTTTCTCCGCCACCGGCGCCGGGATCTACCTCTGGCGTAGTTGTTCCTGGATCAGTAGTTTCTCCGCCACC

>NC_022878|4|4|1932713-1932795|CRISPRCasFinder
CCTGGATCAGTAGTTTCTCCGCCACC	GGCGCCGGGATCTACCTCTGGCGTAGTTGTT
CCTGGATCAGTAGTTTCTCCGCCACC

Protein	Signature genes	Signature genes Name	Protein_function
NC_022878.1\|WP_023519955.1\|1922077_1923280_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226669
NC_022878.1\|WP_023519958.1\|1927398_1928847_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|225519
NC_022878.1\|WP_023519966.1\|1941466_1942267_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|180439
NC_022878.1\|WP_023519969.1\|1944625_1945438_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|223428
NC_022878.1\|WP_019723990.1\|1938554_1939109_-\|PTS-glucitol/sorbitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|367578
NC_022878.1\|WP_023519963.1\|1937531_1938539_-\|PTS-glucitol/sorbitol-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|129905
NC_022878.1\|WP_023519959.1\|1928839_1930426_+\|response-regulator	unknown	unknown	gnl\|CDD\|227095
NC_022878.1\|WP_041684245.1\|1939587_1941450_-\|HTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|226234
NC_022878.1\|WP_023519970.1\|1945434_1946247_+\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|236477
NC_022878.1\|WP_023519961.1\|1934509_1935961_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|181958
NC_022878.1\|WP_010735034.1\|1921741_1922065_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99906
NC_022878.1\|WP_010735032.1\|1923279_1924812_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|184134
NC_022878.1\|WP_080674328.1\|1931532_1931841_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NC_022878.1\|WP_023519956.1\|1925106_1926198_-\|sugar-binding-protein	unknown	unknown	gnl\|CDD\|380649
NC_022878.1\|WP_023519954.1\|1920476_1921565_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380483
NC_022878.1\|WP_010735021.1\|1937158_1937515_-\|PTS-glucitol/sorbitol-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|367683
NC_022878.1\|WP_010735018.1\|1939108_1939591_-\|transcriptional-regulator-GutM	unknown	unknown	gnl\|CDD\|369138
NC_022878.1\|WP_010735027.1\|1930538_1931195_+\|YitT-family-protein	unknown	unknown	gnl\|CDD\|376838
NC_022878.1\|WP_023519957.1\|1926424_1927390_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380532
NC_022878.1\|WP_023519962.1\|1936416_1937121_-\|fructose-6-phosphate-aldolase	unknown	unknown	gnl\|CDD\|183656

Protein	Function_ID	Function_description	E-value
NC_022878.1\|WP_023519955.1\|1922077_1923280_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	4.44485e-141
NC_022878.1\|WP_023519958.1\|1927398_1928847_+\|sensor-histidine-kinase	gnl\|CDD\|225519	COG2972, COG2972, Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms].	1.70946e-47
NC_022878.1\|WP_023519966.1\|1941466_1942267_-\|SDR-family-oxidoreductase	gnl\|CDD\|180439	PRK06171, PRK06171, sorbitol-6-phosphate 2-dehydrogenase; Provisional.	5.74824e-172
NC_022878.1\|WP_023519969.1\|1944625_1945438_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|223428	COG0351, ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme metabolism].	4.75129e-128
NC_022878.1\|WP_019723990.1\|1938554_1939109_-\|PTS-glucitol/sorbitol-transporter-subunit-IIC	gnl\|CDD\|367578	pfam03608, EII-GUT, PTS system enzyme II sorbitol-specific factor.	1.52987e-97
NC_022878.1\|WP_023519963.1\|1937531_1938539_-\|PTS-glucitol/sorbitol-transporter-subunit-IIB	gnl\|CDD\|129905	TIGR00825, EIIBC-GUT, PTS system, glucitol/sorbitol-specific, IIBC component. Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Gut family consists only of glucitol-specific permeases, but these occur both in Gram-negative and Gram-positive bacteria.E. coli consists of IIA protein, a IIC protein and a IIBC protein. This family is specific for the IIBC component. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS].	1.48666e-152
NC_022878.1\|WP_023519959.1\|1928839_1930426_+\|response-regulator	gnl\|CDD\|227095	COG4753, COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms].	1.33345e-61
NC_022878.1\|WP_041684245.1\|1939587_1941450_-\|HTH-domain-containing-protein	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	1.55953e-18
NC_022878.1\|WP_023519970.1\|1945434_1946247_+\|hydroxyethylthiazole-kinase	gnl\|CDD\|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	5.56306e-119
NC_022878.1\|WP_023519961.1\|1934509_1935961_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|181958	PRK09564, PRK09564, coenzyme A disulfide reductase; Reviewed.	1.47582e-70
NC_022878.1\|WP_010735034.1\|1921741_1922065_-\|hypothetical-protein	gnl\|CDD\|99906	cd05564, PTS_IIB_chitobiose_lichenan, PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	4.6904e-23
NC_022878.1\|WP_010735032.1\|1923279_1924812_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|184134	PRK13549, PRK13549, xylose transporter ATP-binding subunit; Provisional.	0
NC_022878.1\|WP_080674328.1\|1931532_1931841_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	1.9808e-06
NC_022878.1\|WP_023519956.1\|1925106_1926198_-\|sugar-binding-protein	gnl\|CDD\|380649	cd19994, PBP1_ChvE, periplasmic sugar binding protein ChvE that interacts with a bacterial two-component signaling system. Periplasmic aldose-monosaccharides binding protein ChvE that belongs to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	2.34439e-155
NC_022878.1\|WP_023519954.1\|1920476_1921565_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|380483	cd01541, PBP1_AraR, ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of AraR is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	2.16944e-118
NC_022878.1\|WP_010735021.1\|1937158_1937515_-\|PTS-glucitol/sorbitol-transporter-subunit-IIA	gnl\|CDD\|367683	pfam03829, PTSIIA_gutA, PTS system glucitol/sorbitol-specific IIA component.	1.66178e-51
NC_022878.1\|WP_010735018.1\|1939108_1939591_-\|transcriptional-regulator-GutM	gnl\|CDD\|369138	pfam06923, GutM, Glucitol operon activator protein (GutM). This family consists of several glucitol operon activator (GutM) proteins. Expression of the glucitol (gut) operon in Escherichia coli is regulated by an unusual, complex system which consists of an activator (encoded by the gutM gene) and a repressor (encoded by the gutR gene) in addition to the cAMP-CRP complex (CRP, cAMP receptor protein). Synthesis of the mRNA, which initiates at the promoter specific to the gutR gene, occurs within the gutM gene. Expressional control of the gut operon appears to occur as a consequence of the antagonistic action of the products of the autogenously regulated gutM and gutR genes.	5.47267e-46
NC_022878.1\|WP_010735027.1\|1930538_1931195_+\|YitT-family-protein	gnl\|CDD\|376838	pfam02588, YitT_membrane, Uncharacterized 5xTM membrane BCR, YitT family COG1284. This is probably a bacterial ABC transporter permease (personal obs:Yeats C).	1.05138e-22
NC_022878.1\|WP_023519957.1\|1926424_1927390_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380532	cd06309, PBP1_galactofuranose_YtfQ-like, periplasmic binding domain of ABC-type galactofuranose YtfQ-like transport systems. Periplasmic binding domain of ABC-type YtfQ-like transport systems. The YtfQ protein from Escherichia coli is up-regulated under glucose-limited conditions and shares homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily. Members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes; however their ligand specificity is not determined experimentally.	1.88917e-112
NC_022878.1\|WP_023519962.1\|1936416_1937121_-\|fructose-6-phosphate-aldolase	gnl\|CDD\|183656	PRK12656, PRK12656, fructose-6-phosphate aldolase; Reviewed.	1.88793e-120

>NC_022878.1|WP_080674328.1|1931532_1931841_-|LPXTG-cell-wall-anchor-domain-containing-protein
MVRTQVLSDNSSNDGLSSNNQTTNTQGTSDSEDVSGKQLPKTGSTSGIFGKFVGGILVAFAGFFGLFKRKRRELQKDEDRVERVIKEEDEEQENKEENKDKK
>NC_022878.1|WP_010735027.1|1930538_1931195_+|YitT-family-protein
MKAEIKKLPVIIVGIISITVGLNMFLLPHQIASAGVGSIGFLLEMVLLIDRTLIVWAINLAMLCLAFIFLERAVFFKTLIGSLIFPIILAYTPALVITQHFPIALVAGSFLFSLGIFILYQIGASNGGVTVPPLIFKKYFGIEHALGVLLTNTVIIALNLVILGIRQAVISAISIYLISFFMKKLLQFQTQFLAIKPIDLVNESSPILDEQPNKNLAE
>NC_022878.1|WP_023519959.1|1928839_1930426_+|response-regulator
MYKIFIAEDEHLIRESLKRMITEFSTFLPLGSIEDASDGELALSMIAEQKPDILLTDIRMPFMNGIELANEVKKLLPDIQIIFISGYDEFTYAKAAIQLQVAEYLLKPIKPNELQKSLEQIIQKLEADSLLKQSKETNGYSLEVQKNFYLNALFNNQLLLSEAIEEGRKLEREIAGNKYMVLLIANHTNKFFSDYDIFHEKMAELFDHDKQILFSSLSSRFIKLLIFDPNEDLLQKKANQVALLSHKTLGHTTDDLVIAIGYPVKRISEIPHSYQTAVHLLSYLKIDPKIKILSYLDYEKKLGNYGQSFDLKESIRLLRKSEISSFVEKLVKQTNQHADPLLVRHLIINELNELVTIRQNQTNQVVSFTTTEEIPNILSERPLFIQYLEQMIYFLKEMVLENHMNQYKEVLEQSITYIENHYFEPELSLKEVANHVHLSSSHFSTIFSQGIGQTFIDYLTEQRLSMARRLLRETNSKLSVIASEVGYNDPNYFSSIFKRKEKISPKEYRKMKKNRTHSLQENNYLVNK
>NC_022878.1|WP_023519958.1|1927398_1928847_+|sensor-histidine-kinase
MKKNESIKVLLRHTSWLMLSLAITPLIISIALYTHYLFSYEKSIHNISIANQIASNVEETIIEEALGLTYGQITPEEFQKSNQINRIKEEISAIKVSTQNSQELATLNIVLRSLDNVSDYLDKIIANIHQKETFAENQALMLHVESAVKLAHDILQDFVKIEIDTASVKSEEVRSSLVILSTIEAVIIALIFLMTRKFNTKMMYQIQQPMDEMIKMADALAEGHLNHRIKTPQNNELKKLSNSMNDMADNLVILLEENALKQYNLAQSEVRTLQAQIIPHFIYNSLDAILVLAEMGQIEKVKEMTYSLSDFFRISLSQGKDWIPVEQEIRHCDNYLKILQIRYGDQLSYQLTIDPKVNNHPILKMILQPLIENAVYHGTKLVRRPGKIIVKAYIDQEEFIHFWIIDNGKGITETKLEEINQELADGLDTNFHKGYGLFNVNKRLLLYYGTDASIKITSRIDHGTVIHVVVPTKNIDRNEANV
>NC_022878.1|WP_023519957.1|1926424_1927390_+|ABC-transporter-substrate-binding-protein
MKNKSFFILAAFCLLLTGCAFNSTEPTKNELTIGFSQAGTESNWRKVQNQSIKEALEKQNFQVLHRNSYSDPKQQIQDVMTFIAYQVDMIVLSPIEETGWDSVLEEAKEANIPVIIVDRNITTEKQDLYLTHIGSSFKAQGSRAGLYVTNHYQQKTQESIQVFEIRGSENTSPTRLRSDGFLETIGRDPRIHVRQVITGDYIRLKAKEQFSKAIDEGKLQGIDVIYSHNDEMTLGALDAIKEKKLEKNFVIVSIDAQKEMIDQLKKGKVNCVVECNPFMGELVANTVKRYFEKKAIPQDIYVSDTVFSDQNDFSTIPPRGY
>NC_022878.1|WP_023519956.1|1925106_1926198_-|sugar-binding-protein
MKRVGKNWLVAIVFLLMSVTVFAGCSNGSAAGDEKGFVGISMPTKSAERWIADGDNMVKQLEEKGYKTDLQYGEDKVENQVAQIENMITKGVDTLVIASIDGSALTDVLEKAHQADIKVIAYDRLLMNSEYVDYYATFDNFGVGVLQASYIEDKLDLKDGAGPFTIELFGGSPDDNNALINYNGVMSILQPYIDSKQLNVSSGQTKFNQIATLRWDGSTAQARMDNLLSANYTDDQLDAVLSPYDPISLGIISSLKGVGYGSADKPLPVITGQDATIAGVKSIIAGEQTQTIFKDTRVLADNTVEMIEAINNDKEVPVNDEETYDNGVKVIPTYLANPVSVDKENYKQELIDTEYYSESDLGQ
>NC_022878.1|WP_010735032.1|1923279_1924812_-|ATP-binding-cassette-domain-containing-protein
MADYILEMKEIIKEFSGVRALNNVNLRIKRGEIHALCGENGAGKSTLMNVLSGLYPYGSYSGEIMYDGEVCQFKNLRDSEAKGIVIIHQELALSPYLSIKENIFLGNEQTKHGVIDWNLTERKTENLLKTVGLKIDPNTLVSQIGVGHQQLVEIAKAFSKNVRLLILDEPTAALNEEESANLLALIKEFRNQGITSIIISHKLNEIVAVADRITILRDGQTIETLENTAISEERIIKGMVGRDLTNRYPDRHPDIGEVYFEVKDWTVHHPLTTDRIINDHIDFSIRRGEIVGIAGLMGAGRTEFAMSIFGRSYGSNLSGKIFKDGKELVIKDVSQAIDHGLAYVSEDRKSVGLNLLMDIRENTTIASLKKISRSGILDQEKEVIEAENFRKKMRTKATNVFQNVGSLSGGNQQKVVLAKWLMTEPEILFLDEPTRGIDVGAKYEIYTIIEEMAALGKCVCIISSELPEIIGMCDRIYTMNEGKMTGEVLREEANQELLMNLMTKEEEAVG
>NC_022878.1|WP_023519955.1|1922077_1923280_-|sugar-ABC-transporter-permease
MENVTKKSQEKKAWNVKEKILDIFSKYSMVIILVALLIAFQLMTGGIFLRPLNITNIVLQNSHILILAAGMLLVVLLGYVDLSVGSVMAFVGAMAGMLMVNNNISPWLAVPLCLLVGGVIGAWQGFWVAYVGIPAFIVTLAGLLMFRGLTQVVLGGQSLAPFPGGFQKISTGYLPDIFGVPGMHLLTLILGVVLAVSLVFAQWRARARRKENLFEVPSMNAFLIKAALTIVLVLGLSYIFASYQGFPVILIILGVIVGIYGFLTNRTVAGRQIYATGGNLKAAQLSGIKTKKITFWVFVNMGVMAALAGLILAARLNAATPQAGTSLELDAMASVYFGGASTSGGIGTITGAIVGGLVMGVLNNGMSIMGVGVDWQQAIKGLILLLAVVLDIYNKKRKIS
>NC_022878.1|WP_010735034.1|1921741_1922065_-|hypothetical-protein
METTEEKRILLICTAGITSGLLVKNIQNAANEKGVPLHVYSAPAIVAEQAIQNQQIDGLMIGPQSEYEVERLKDFLTVKAVPYKLIRKEDYESFDGESVLADILQFF
>NC_022878.1|WP_023519954.1|1920476_1921565_-|GntR-family-transcriptional-regulator
MDKTKYQMIADEIKDKIIDQIFKLNEPIPPELQLQKDYQVSRHTVRQAIGLLVNEGYLRKEKGSGTYVDDTYKKTSQSRKNQKTIGVITTYLSDYIFPSIIRGIEKALSEQGYSLLLASTNNDHQQEKNCLEKMLQFGVDGLIVEPTKSNEYNPNLALYVRLREQGIPMVMINAVYEELAVASICVDDVKVGFKGTEYLIQQGHQRLLFITKIDDLQGKYRMKGFIQACEAYGIQFSPEDIITYTTDSRGKLGEKVLLQLKESASTGIICYNDQVASQLLDEVIAKGYQVPQQLSIIGNDDSSLSQMGAVKLTTLTHPKERMGKDAAEWIIHTIQTGNQGENIVYEPSLVIRDSVSATKNGE
>NC_022878.1|WP_023519961.1|1934509_1935961_-|FAD-dependent-oxidoreductase
MRIIIVGGNHAGIAAALRIREEYPDDEVIVFEKKDEITFVSQTIPLFLMGHQDIHSQANYATPHEIIAQGVDLRIQKEVTNIDAKKKTLNFRNVLSQHEHEITYDRLIMAAGSYPNLPPTGGKLNETLFLLKERKDAEAIEKFISEAHHAVVIGAGLVGVEIARILAQRKMKVTLIQSNARILDKYLDENAAIEVEKQLEEEGIQLLLGTRVTSYHTIDKKIWSRPKIEVETSSDLTIRADGVFVSVGFRPNSFLLAGQVETGDRGAIVVDKYMYTTDDSILAIGDCSTTYMDLTKENIYNPHASDAFRQGLIAAVNIHEKKQEVAMTTGTYKFNMDGFTIANTGITLNQARKFGYDAEEVHYQNRYLERGGQLVHESIVKYSPIEKGRKNHYSSIYLVYEKKTKKILGLQVLGTVDISQYVNIISLAIQKNVTVPEIEFTDFFYEHGYKNPLGFTKILASLVREKERESGRDGKEERSNEIK
>NC_022878.1|WP_023519962.1|1936416_1937121_-|fructose-6-phosphate-aldolase
MEFMLDTINIEKISYYQSILPLSGVTSNASIIKKEGKIDLFAHLKEIKKLIGKASLHVQVVGETTEEILTDAQVIMDHLGKDIFIKVPVNEPGLAAIKQLKAKGAYVTATAIYSEMQGYLAIAAGADYVAPYYNRMENLNIDAVAIIKALAMEIERTQSQSKILAASFKNVAQVNHACRQGAHSITASPDIFAQVFGMPSIHKAVTDFRKDWEETFGVKDVKALAATGAISLTK
>NC_022878.1|WP_010735021.1|1937158_1937515_-|PTS-glucitol/sorbitol-transporter-subunit-IIA
MSVYSTKVTSIGAEATLFKEEKLVILFGKDAPDMLSAYCYHIELQPIHGEIKVGQQLFVDETSYRITSVGSLVNDNLKELGHITIKFDGAVTPELPGTLYVEGKEIVEIGIKTKISIK
>NC_022878.1|WP_023519963.1|1937531_1938539_-|PTS-glucitol/sorbitol-transporter-subunit-IIB
MSYHSIRIVRGTGGFGGPLVITPTEEKHKFIYITGGGEKPAIVDKIAELTGMEAVNGFKTSIPDNEIALAIVDCGGTLRCGIYPKKGIPTINVVPTGKSGPLAQYITEDISVSAVGINQITLTTEEGTVGQSDNIENKRVAAREYKYDTSKKITEQKAEQQNFIAKIGMGAGKVVATFNQSAREGVQTMINTVIPFMAFVSLLIGIIQGSGIGNFFANIMAPLAGNIWGLMIIGFICSLPFLSPLLGPGAVISQVIGTLIGVEIGKGNIPPQLALPALFAINTQNACDFIPVGLGLEEAEAETVEVGVPSVLYSRFLNGVPRVLVAWIASFGMYS
>NC_022878.1|WP_019723990.1|1938554_1939109_-|PTS-glucitol/sorbitol-transporter-subunit-IIC
MEYITKFAEGFIGLFETGAETFISWMTGIVPVVLILMVAMNTLIAFLGEERVTKVAKLSTKNPVTRYLILPFLSAFMLGNPMSFTMARFLPEYYKPSYYASQAQFCHTSNGVFPHINPGELFVWLGIAQGITTLGLNSMELAVRYMFVGILMNFIGGWVTDFTTAYVCKQQGVTLSKTVETATE
>NC_022878.1|WP_010735018.1|1939108_1939591_-|transcriptional-regulator-GutM
MNFIYIFGAFALVAYGLQVIFGMKQIKHFNQIYLEMRRKGKVAIGRRSGKIKAGTIVMFAVDQKGIIIDARKMQGVTVLAKFRLLPQYIGTDIHYIDNYHPLVRTENKLVQQAMANAREIYLRVELGNYQEESLPSPLTMLGIQFSLWKKQYLSKKRSVE
>NC_022878.1|WP_041684245.1|1939587_1941450_-|HTH-domain-containing-protein
MTVVNRWYQILQLLVTHKEMRIGSLKQQLNTSTQTVKTSIESLNEELIGIAEIVQHKNDFHIEIENFEKFDLIMNGSLRRKSDFNSCSKRVFFIVKKLIEQKDFLLIDDLSEALGVSRSTVVKDLRVMKKLISSFNVEVIGTPNRGLRMRGEELDLRLLHLHYVQEYFAERPLSERTQDFVEHLVQKFNLPKNQGLLLKKTISITMKRLLKGNILVDLPNEYMDLMTSHPAFVELIHHLEYEYSITLSQTEQAFLSFPLNISAIAGMDKSTIDEQKIEQLFQQMIETIHQNLLVEFDETFLVHEIKEHFIYMLNRLIFRIELQDLFYGEIESQYPLAYELAKIGLQQIGEQLQRVVPTVEISYIAFYFELALRKQTSNNEHKEIAIVCNTGKGTALIIRRQLERVLGPQIIMVHFSEEEYQQEDLDQYFAVFTTIPLKNVKKHTPIIRLINLFNETWLQEEWRKAEKLRAANVHHLKLDFEILNEKKPYKQNLDHMLESLESKGLVDQEFKEQLFIREKLRSTIFEYGIAFPHAINKKSAEIILSVGIFRKGISTINGQVQVVLLLAIPQDLTMEKEKELLKLYDQLFAVIGDPEFRSELCRLDDLVGLQNWMIRKGVIT
>NC_022878.1|WP_023519966.1|1941466_1942267_-|SDR-family-oxidoreductase
MTNWLNIERKTIIVTGGSSGIGKSIVESLLEQHVNVANFDIKDSTLKHQRLLFVKTNITLRQEVEAGVAKVKDHFGTIDGLVNNAGINIPRLLVDKKQAHGRYELSEEVFDKIIAINQKGLYLMTQAVSRILVAKGEGVIINMSSESGLEGSEGQSAYAATKAAVNSFTRSWAKELGKSNVRVIGIAPGIMEETGLRTLSYEEALAYTRGITIEELRAGYAKTSTIPLGRSGKLKEVADLVSYYLSDRSSYITGVTTNVAGGKTRG
>NC_022878.1|WP_023519969.1|1944625_1945438_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MKKVLSIAGSDCSGGAGIQADLKTFAAHGVYGMSVITSVVAENTARVISYQDIAPTIINEQMTAVFEDIYPDAVKIGMLSCADTMLAVASSLQEWQPKNIVLDPVMYAKNGDALMEPEAIDTLIKNVLPLATLITPNIPEAEKIADRSITSLEEMERAAKAIYETCHAAVLIKGGHRTGEATDILYDGKNIYSYTSERIVTKNTHGTGCTFSSAIASQLALGVPLDQAISKAKKYITTAIAHSLELGEGHGPTNHFYSLYRNGLKEEQSQ
>NC_022878.1|WP_023519970.1|1945434_1946247_+|hydroxyethylthiazole-kinase
MNTFLKTAVETVRMKNPLVHHITNYVTVNDCANVTLAIGGSPIMADDALEVAEITAMSQALVLNMGTLNERTVASMLSAGQTANEKGIPIIFDPVGAGASQFRNQTAKTIIENLKCAVIRGNISEIRFLAGIASTTKGVDASADDASSIEEAQRIADQLATAHKCIVVITGATDVISDGRRKILVHNGCPEMSRITGTGCMLTSLIASFCGGSPEHLFHAATTAVLTMGIAGELALEQTAGTGSFRIALIDEISRIDRETLLLRGNYFEK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022878_3	3.1\|821480\|29\|NC_022878\|CRISPRCasFinder	821480-821508	29	NZ_CP022523	Pseudoalteromonas sp. NC201 plasmid pNC201, complete sequence	257055-257083	7	0.759

1. spacer 3.1|821480|29|NC_022878|CRISPRCasFinder matches to NZ_CP022523 (Pseudoalteromonas sp. NC201 plasmid pNC201, complete sequence) position: , mismatch: 7, identity: 0.759

tgaagcgttagagttattgcgatggatgc	CRISPR spacer
ttgatgaatagaattattgcgatggatgc	Protospacer
* .*  . ****.****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

806635 : 852594

Streptococcus_phage(27.27%)

holin,capsid,head,integrase,plate,portal,tail,terminase,protease

attL 806547:806564|attR 845198:845215

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
806547:806564	attL	NA	NA	NA	NA
WP_023519281.1\|806635_807763_-\|integrase	site-specific integrase	Q9AZR0	Lactococcus_phage	4.0e-96	45.7
WP_023519282.1\|807877_808522_-	hypothetical protein	NA	NA	NA	NA
WP_023519283.1\|808612_809452_-	helix-turn-helix domain-containing protein	A0A2H4J386	uncultured_Caudovirales_phage	1.4e-34	51.3
WP_023519284.1\|809624_809858_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_023519285.1\|809918_810668_+	antA/AntB antirepressor family protein	A0A2D1GPQ2	Lactobacillus_phage	3.9e-55	48.4
WP_023519286.1\|810681_810996_+	DUF771 domain-containing protein	U3PBP3	Staphylococcus_phage	5.4e-11	39.4
WP_023519287.1\|811008_811176_+	hypothetical protein	NA	NA	NA	NA
WP_023519288.1\|811273_811609_+	hypothetical protein	NA	NA	NA	NA
WP_023519289.1\|811605_811830_+	hypothetical protein	NA	NA	NA	NA
WP_023519290.1\|811841_812195_+	hypothetical protein	NA	NA	NA	NA
WP_023519291.1\|812187_812379_+	hypothetical protein	NA	NA	NA	NA
WP_023519292.1\|812381_813404_+	recombinase RecT	A0A1X9I5N6	Streptococcus_phage	2.1e-56	49.4
WP_193363094.1\|813387_814182_+	PD-(D/E)XK nuclease-like domain-containing protein	J7KGZ1	Streptococcus_phage	3.2e-60	52.2
WP_023519294.1\|814199_814991_+	hypothetical protein	Q6J1V6	Lactobacillus_phage	2.7e-43	45.6
WP_023519295.1\|814990_815839_+	ATP-binding protein	A0A2D1GQF9	Lysinibacillus_phage	5.4e-21	30.6
WP_023519296.1\|815835_816078_+	hypothetical protein	NA	NA	NA	NA
WP_023519298.1\|816220_816667_+	DUF1064 domain-containing protein	A0A2H4J891	uncultured_Caudovirales_phage	1.8e-12	35.5
WP_023519299.1\|816687_817122_-	hypothetical protein	NA	NA	NA	NA
WP_023519300.1\|817173_817746_+	hypothetical protein	NA	NA	NA	NA
WP_023519301.1\|817745_817934_+	hypothetical protein	NA	NA	NA	NA
WP_023519302.1\|817944_818139_+	hypothetical protein	NA	NA	NA	NA
WP_023519304.1\|818263_818659_+	YopX superfamily protein	D2IZL0	Enterococcus_phage	7.3e-13	39.7
WP_023519305.1\|818655_819714_+	DNA (cytosine-5-)-methyltransferase	A0A1X9I6Y5	Streptococcus_phage	1.6e-139	66.9
WP_023519306.1\|819727_819943_+	hypothetical protein	NA	NA	NA	NA
WP_023519307.1\|819935_820511_+	DUF1642 domain-containing protein	A8E2L2	Enterococcus_phage	2.6e-19	39.5
WP_023519308.1\|820507_820729_+	hypothetical protein	NA	NA	NA	NA
WP_023519309.1\|820725_821082_+	hypothetical protein	NA	NA	NA	NA
WP_023519310.1\|821071_821269_+	hypothetical protein	NA	NA	NA	NA
WP_023519311.1\|821268_821463_+	hypothetical protein	D2IYV2	Enterococcus_phage	4.5e-08	47.1
WP_023519312.1\|821813_822290_+	hypothetical protein	A0A2H4JFW6	uncultured_Caudovirales_phage	6.3e-27	50.4
WP_023519313.1\|822497_823568_+	DUF4062 domain-containing protein	NA	NA	NA	NA
WP_051377632.1\|823951_824194_+	hypothetical protein	NA	NA	NA	NA
WP_023519316.1\|824180_824522_+	HNH endonuclease	J7KH36	Streptococcus_phage	1.1e-28	53.3
WP_023519317.1\|824679_825144_+\|terminase	phage terminase small subunit P27 family	J7KC46	Streptococcus_phage	5.9e-46	57.1
WP_023519318.1\|825182_826925_+\|terminase	terminase large subunit	A0A2H4JBN3	uncultured_Caudovirales_phage	1.1e-209	63.0
WP_023519320.1\|827136_828399_+\|portal	phage portal protein	A0A2H4JGQ4	uncultured_Caudovirales_phage	9.8e-128	57.7
WP_041684392.1\|828337_828955_+\|head,protease	HK97 family phage prohead protease	U5U3W0	Lactobacillus_phage	2.8e-51	51.7
WP_023519322.1\|829012_830227_+\|capsid	phage major capsid protein	A0A2H4J9X8	uncultured_Caudovirales_phage	1.6e-98	50.4
WP_023519323.1\|830244_830538_+	hypothetical protein	NA	NA	NA	NA
WP_023519324.1\|830524_830878_+\|head,tail	phage gp6-like head-tail connector protein	A0A2H4J9W3	uncultured_Caudovirales_phage	3.2e-20	58.0
WP_023519325.1\|830864_831200_+\|head	phage head closure protein	M1PFA2	Streptococcus_phage	1.6e-08	32.8
WP_023519326.1\|831196_831562_+	HK97 gp10 family phage protein	M1PKN1	Streptococcus_phage	1.1e-26	52.4
WP_023519327.1\|831558_831975_+	hypothetical protein	M1Q110	Streptococcus_phage	3.6e-26	46.5
WP_023519328.1\|832015_832594_+\|tail	major tail protein	A0A0D4DCZ2	Staphylococcus_phage	3.1e-12	30.6
WP_023519329.1\|832664_832991_+	hypothetical protein	NA	NA	NA	NA
WP_023519330.1\|833008_833173_+	hypothetical protein	NA	NA	NA	NA
WP_051377633.1\|833271_837780_+\|tail	phage tail tape measure protein	J7KDT4	Streptococcus_phage	1.9e-85	34.2
WP_023519332.1\|837776_838598_+\|tail	phage tail family protein	Q9T1A6	Listeria_phage	1.8e-50	40.4
WP_023519333.1\|838606_839635_+\|tail	phage tail protein	A0A0B5D0G3	Listeria_phage	2.1e-80	44.0
WP_023519334.1\|839634_840681_+	hypothetical protein	Q9T1A4	Listeria_phage	1.0e-21	27.1
WP_023519335.1\|840681_842868_+\|plate	phage baseplate upper protein	A0A096XSZ6	Enterococcus_phage	1.1e-86	47.0
WP_023519336.1\|842880_843228_+	hypothetical protein	NA	NA	NA	NA
WP_023519337.1\|843220_843349_+	XkdX family protein	NA	NA	NA	NA
WP_023519338.1\|843359_843593_+	hypothetical protein	NA	NA	NA	NA
WP_023519339.1\|843594_843852_+\|holin	holin	A0A0U4JE55	Bacillus_phage	2.1e-05	41.8
WP_023519340.1\|843920_844814_+	N-acetylmuramoyl-L-alanine amidase	A0A142F1N7	Bacillus_phage	3.8e-41	54.5
WP_023519341.1\|845324_845630_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
845198:845215	attR	NA	NA	NA	NA
WP_010736021.1\|845681_846014_-	hypothetical protein	NA	NA	NA	NA
WP_010736020.1\|846387_846738_+	hypothetical protein	NA	NA	NA	NA
WP_023519342.1\|846822_847359_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_010736018.1\|847505_848111_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_010736017.1\|848394_848754_+	DUF1304 domain-containing protein	NA	NA	NA	NA
WP_023519344.1\|848878_850513_+	SulP family inorganic anion transporter	A0A2H4J153	uncultured_Caudovirales_phage	3.7e-26	26.9
WP_023519345.1\|850595_850970_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_010736014.1\|851040_851685_-	uracil-DNA glycosylase	NA	NA	NA	NA
WP_019723824.1\|851912_852221_+	50S ribosomal protein L21	NA	NA	NA	NA
WP_010736012.1\|852249_852594_+\|protease	ribosomal-processing cysteine protease Prp	NA	NA	NA	NA

DBSCAN-SWA_2

1220299 : 1229331

Gordonia_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023519514.1\|1220299_1221595_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	2.5e-17	32.0
WP_010735685.1\|1221735_1222113_-	hypothetical protein	NA	NA	NA	NA
WP_010735684.1\|1222369_1223101_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4SM18	Cyanophage	2.1e-45	41.8
WP_010735683.1\|1223104_1223359_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_023519515.1\|1223360_1224035_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_023519516.1\|1224035_1226258_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.5e-150	41.5
WP_010735680.1\|1226242_1227682_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.4e-53	33.7
WP_023519517.1\|1227712_1228756_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	3.7e-64	43.9
WP_023519518.1\|1228752_1229331_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.6e-27	37.0

DBSCAN-SWA_3

1511146 : 1520514

Bacillus_phage(37.5%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080674324.1\|1511146_1512295_-	isochorismate synthase	A0A0B5J984	Pandoravirus	2.6e-10	26.4
WP_023519697.1\|1512485_1513970_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	8.4e-62	32.0
WP_010735416.1\|1513944_1514760_-	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
WP_023519698.1\|1515199_1515487_-\|transposase	transposase	A0A1X9I5Z0	Streptococcus_phage	3.1e-05	38.6
WP_010735415.1\|1515767_1516769_-	amidase	A0A142F1N7	Bacillus_phage	3.7e-37	52.7
WP_080674325.1\|1516891_1517776_-	N-acetylmuramoyl-L-alanine amidase	A0A142F1N7	Bacillus_phage	2.4e-40	58.3
WP_010735413.1\|1517821_1518094_-	hypothetical protein	A0A0U4JE55	Bacillus_phage	4.9e-08	43.0
WP_023519700.1\|1518095_1518329_-	hypothetical protein	NA	NA	NA	NA
WP_023519701.1\|1518616_1519030_-	ArpU family transcriptional regulator	C9E2P5	Enterococcus_phage	1.5e-32	57.1
WP_023519702.1\|1519671_1519932_-	hypothetical protein	NA	NA	NA	NA
WP_023519703.1\|1520067_1520514_+	helix-turn-helix transcriptional regulator	S4V691	Staphylococcus_phage	2.9e-10	34.8

DBSCAN-SWA_4

1832145 : 1840615

Streptococcus_phage(42.86%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010735121.1\|1832145_1832742_+	TVP38/TMEM64 family protein	M1Q152	Streptococcus_phage	1.8e-31	39.1
WP_010735118.1\|1835240_1835390_+	hypothetical protein	NA	NA	NA	NA
WP_023519900.1\|1835532_1835922_-\|holin	phage holin family protein	A0A097BY69	Enterococcus_phage	4.6e-20	39.1
WP_010735116.1\|1836238_1836601_+	helix-turn-helix transcriptional regulator	A0A1S5SDR1	Streptococcus_phage	5.3e-18	38.7
WP_019722947.1\|1836607_1837036_+	ImmA/IrrE family metallo-endopeptidase	I3VYZ2	Thermoanaerobacterium_phage	6.9e-09	32.1
WP_010735114.1\|1837152_1838217_+	type I restriction enzyme HsdR N-terminal domain-containing protein	A0A1S5SAB0	Streptococcus_phage	6.4e-112	57.4
WP_010735111.1\|1838776_1838974_-	cold-shock protein	Q9AZD3	Lactococcus_phage	8.6e-23	75.4
WP_023519901.1\|1839187_1839580_-	hypothetical protein	NA	NA	NA	NA
WP_010735112.1\|1839785_1840244_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_010735111.1\|1840417_1840615_-	cold-shock protein	Q9AZD3	Lactococcus_phage	8.6e-23	75.4

DBSCAN-SWA_5

2333100 : 2357318

Enterococcus_phage(33.33%)

holin,capsid,plate,tail,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023520190.1\|2333100_2333745_+	lytic polysaccharide monooxygenase	A0A0K1Y848	Apis_mellifera_filamentous_virus	8.0e-17	31.2
WP_023520191.1\|2333944_2334787_+	toll/interleukin-1 receptor domain-containing protein	A0A097BYB4	Enterococcus_phage	1.8e-64	66.1
WP_023520192.1\|2334775_2335012_-	hypothetical protein	A0A097BYC7	Enterococcus_phage	9.3e-16	52.6
WP_023520193.1\|2335067_2335961_-	N-acetylmuramoyl-L-alanine amidase	A0A142F1N7	Bacillus_phage	9.0e-43	55.1
WP_023520194.1\|2336029_2336287_-\|holin	holin	A0A0U4JE55	Bacillus_phage	6.2e-05	40.5
WP_023520195.1\|2336288_2336522_-	hypothetical protein	NA	NA	NA	NA
WP_023520196.1\|2336532_2336661_-	XkdX family protein	NA	NA	NA	NA
WP_023520197.1\|2336653_2337001_-	hypothetical protein	NA	NA	NA	NA
WP_023520198.1\|2337013_2339200_-\|plate	phage baseplate upper protein	A0A0C5K8Z4	Enterococcus_phage	3.5e-104	55.0
WP_023520199.1\|2339200_2340247_-	hypothetical protein	NA	NA	NA	NA
WP_023520200.1\|2340246_2341275_-\|tail	phage tail protein	A0A0B5D0G3	Listeria_phage	9.6e-81	44.0
WP_023520201.1\|2341283_2342114_-\|tail	phage tail family protein	Q9T1A6	Listeria_phage	3.7e-59	42.5
WP_023520202.1\|2342106_2347362_-	tape measure protein	A0A0S2MYN1	Enterococcus_phage	1.2e-38	23.8
WP_010733994.1\|2347354_2347924_-	bacteriophage Gp15 family protein	Q5YA62	Bacillus_phage	4.8e-42	48.4
WP_023520203.1\|2347932_2348394_-	hypothetical protein	Q5YA63	Bacillus_phage	5.5e-12	38.0
WP_158411071.1\|2348421_2348520_-	hypothetical protein	NA	NA	NA	NA
WP_010733992.1\|2348537_2349014_-	hypothetical protein	NA	NA	NA	NA
WP_010733991.1\|2349024_2349402_-\|capsid	minor capsid protein	Q5YA65	Bacillus_phage	2.0e-12	32.8
WP_023520205.1\|2349401_2349764_-\|capsid	minor capsid protein	A0A1S5SEB7	Streptococcus_phage	8.7e-13	35.0
WP_023520206.1\|2349763_2350099_-\|capsid	minor capsid protein	NA	NA	NA	NA
WP_023520207.1\|2350095_2350551_-	hypothetical protein	NA	NA	NA	NA
WP_023520208.1\|2350577_2350742_-	hypothetical protein	NA	NA	NA	NA
WP_010733986.1\|2350738_2351626_-	hypothetical protein	U3PDP8	Lactobacillus_phage	1.2e-66	46.9
WP_010733985.1\|2351639_2352230_-	phage scaffolding protein	D2J060	Enterococcus_phage	2.1e-16	36.5
WP_023520209.1\|2352463_2353612_-\|capsid	phage minor capsid protein	O03929	Lactobacillus_phage	4.4e-58	37.4
WP_023520212.1\|2355169_2356456_-\|terminase	PBSX family phage terminase large subunit	I1TLD6	Bacillus_phage	6.3e-130	55.4
WP_023520213.1\|2356439_2357318_-\|terminase	terminase small subunit	D2IYW0	Enterococcus_phage	1.5e-79	64.3

DBSCAN-SWA_6

2367070 : 2373664

Enterococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_023520235.1\|2367070_2368033_-	phage replisome organizer N-terminal domain-containing protein	A0A2H4J2I9	uncultured_Caudovirales_phage	5.7e-35	56.1
WP_023520236.1\|2368051_2368738_-	hypothetical protein	C9E2N1	Enterococcus_phage	1.1e-88	68.6
WP_010733950.1\|2370264_2370453_-	hypothetical protein	D2IZW5	Enterococcus_phage	1.3e-07	58.6
WP_023520241.1\|2370641_2370911_+	hypothetical protein	NA	NA	NA	NA
WP_023520242.1\|2370907_2371306_-	hypothetical protein	NA	NA	NA	NA
WP_023520243.1\|2371317_2372073_-	phage antirepressor	A0A1Q1PVU2	Staphylococcus_phage	4.6e-80	58.0
WP_023520244.1\|2372090_2372399_-	DUF771 domain-containing protein	NA	NA	NA	NA
WP_023520245.1\|2372402_2372606_-	hypothetical protein	NA	NA	NA	NA
WP_023520246.1\|2372911_2373250_+	helix-turn-helix transcriptional regulator	Q7Y4M0	Streptococcus_phage	6.9e-20	49.5
WP_023520247.1\|2373259_2373664_+	ImmA/IrrE family metallo-endopeptidase	D2IZV8	Enterococcus_phage	7.7e-10	35.6

DBSCAN-SWA_7

2411276 : 2418363

Staphylococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010734606.1\|2411276_2411855_+	DUF4352 domain-containing protein	A8ASM1	Listeria_phage	5.9e-19	38.4
WP_023520269.1\|2412102_2412564_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.3e-37	58.7
WP_023520270.1\|2412582_2413758_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	8.6e-102	50.0
WP_023520271.1\|2413754_2414375_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	7.9e-30	37.7
WP_023520272.1\|2414359_2415433_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	6.1e-46	32.3
WP_010736620.1\|2416233_2416476_+	hypothetical protein	NA	NA	NA	NA
WP_010736621.1\|2416575_2417205_-	uracil phosphoribosyltransferase	NA	NA	NA	NA
WP_010736622.1\|2417421_2418363_-	alpha/beta hydrolase	A0A167RJ59	Powai_lake_megavirus	3.1e-70	42.6

DBSCAN-SWA_8

2548025 : 2620211

Enterococcus_phage(33.33%)

tRNA,capsid,transposase,integrase,plate,portal,tail,terminase

attL 2556843:2556862|attR 2597575:2597594

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010734358.1\|2548025_2549321_+\|transposase	ISL3 family transposase	A0A2D1GQC1	Lysinibacillus_phage	2.1e-08	21.2
WP_010734294.1\|2549419_2550556_-	AI-2E family transporter	NA	NA	NA	NA
WP_010734293.1\|2550663_2551377_-	MgtC/SapB family protein	G3MA03	Bacillus_virus	7.2e-19	44.4
WP_023520342.1\|2551518_2552220_-	glucosamine-6-phosphate deaminase	NA	NA	NA	NA
WP_023520343.1\|2552439_2553654_-	MFS transporter	NA	NA	NA	NA
WP_023520344.1\|2553734_2554412_-	TVP38/TMEM64 family protein	NA	NA	NA	NA
WP_023520345.1\|2555026_2555377_-	hypothetical protein	NA	NA	NA	NA
WP_010734287.1\|2555500_2555695_-	hypothetical protein	NA	NA	NA	NA
WP_010734286.1\|2556255_2556513_+	hypothetical protein	NA	NA	NA	NA
2556843:2556862	attL	NA	NA	NA	NA
WP_023520346.1\|2557382_2557706_-	hypothetical protein	NA	NA	NA	NA
WP_023520347.1\|2558029_2558395_+	hypothetical protein	NA	NA	NA	NA
WP_023520348.1\|2558983_2559577_-	hypothetical protein	NA	NA	NA	NA
WP_023520349.1\|2559566_2560919_-	ATP-binding protein	V9QJ85	Oenococcus_phage	1.8e-74	36.7
WP_023520350.1\|2561038_2561932_-	N-acetylmuramoyl-L-alanine amidase	A0A142F1N7	Bacillus_phage	2.6e-42	55.7
WP_023520351.1\|2562000_2562258_-	hypothetical protein	A0A0U4JE55	Bacillus_phage	1.6e-05	43.0
WP_023520352.1\|2562259_2562493_-	hypothetical protein	NA	NA	NA	NA
WP_023520353.1\|2562525_2564145_-\|plate	BppU family phage baseplate upper protein	A0A096XSZ6	Enterococcus_phage	4.5e-85	48.6
WP_023520354.1\|2564205_2566005_-\|plate	BppU family phage baseplate upper protein	NA	NA	NA	NA
WP_023520355.1\|2566008_2568336_-\|tail	phage tail protein	A0A1G5SAE0	Enterococcus_phage	3.8e-101	40.4
WP_023520356.1\|2568332_2569088_-\|tail	phage tail component protein	A0A1G5SCA8	Enterococcus_phage	1.4e-36	33.1
WP_023520357.1\|2569080_2574003_-	tape measure protein	A0A0S2MYN1	Enterococcus_phage	7.5e-22	20.9
WP_023520358.1\|2573989_2574571_-	bacteriophage Gp15 family protein	A0A1S5SAD5	Streptococcus_phage	1.1e-20	36.9
WP_041684299.1\|2574575_2574971_-	hypothetical protein	NA	NA	NA	NA
WP_023520360.1\|2575010_2575529_-	hypothetical protein	A0A1S5SEC5	Streptococcus_phage	5.2e-35	54.3
WP_023520361.1\|2575529_2575928_-\|capsid	minor capsid protein	NA	NA	NA	NA
WP_023520362.1\|2575927_2576293_-\|capsid	minor capsid protein	B3GW08	Streptococcus_phage	6.1e-14	39.1
WP_023520363.1\|2576292_2576628_-\|capsid	minor capsid protein	NA	NA	NA	NA
WP_023520364.1\|2576624_2577080_-	hypothetical protein	NA	NA	NA	NA
WP_023520365.1\|2577110_2578220_-\|capsid	phage major capsid protein	Q9T1B7	Listeria_phage	9.3e-114	70.4
WP_023520367.1\|2579103_2580252_-\|capsid	phage minor capsid protein	O03929	Lactobacillus_phage	2.7e-55	37.7
WP_023520368.1\|2580256_2581822_-\|portal	phage portal protein	Q5YA75	Bacillus_phage	2.6e-114	44.6
WP_023520369.1\|2581833_2583150_-\|terminase	PBSX family phage terminase large subunit	Q5YA76	Bacillus_phage	1.1e-169	65.0
WP_023520370.1\|2583146_2583857_-	hypothetical protein	D6PSW8	Lactobacillus_phage	1.6e-39	49.5
WP_023520371.1\|2583897_2584176_-	hypothetical protein	A0A1X9I661	Streptococcus_phage	1.9e-12	44.3
WP_023520372.1\|2584204_2584387_-	hypothetical protein	NA	NA	NA	NA
WP_041684301.1\|2584916_2585333_-	autolysin	C9E2P5	Enterococcus_phage	1.3e-47	69.6
WP_023520375.1\|2585417_2585705_-	hypothetical protein	NA	NA	NA	NA
WP_023520376.1\|2585701_2586004_-	hypothetical protein	NA	NA	NA	NA
WP_023520377.1\|2586000_2586222_-	hypothetical protein	NA	NA	NA	NA
WP_080674333.1\|2586218_2586830_-	DUF1642 domain-containing protein	D2IYV1	Enterococcus_phage	3.3e-12	54.4
WP_023520379.1\|2586918_2588208_-	DNA (cytosine-5-)-methyltransferase	A0A1S5SDI9	Streptococcus_phage	1.1e-131	56.1
WP_023520380.1\|2588210_2588558_-	YopX superfamily protein	D2IZL0	Enterococcus_phage	3.3e-33	61.2
WP_023520381.1\|2588554_2588857_-	hypothetical protein	NA	NA	NA	NA
WP_023520382.1\|2588849_2589014_-	hypothetical protein	NA	NA	NA	NA
WP_148294501.1\|2589003_2589291_-	hypothetical protein	NA	NA	NA	NA
WP_023520384.1\|2589309_2590032_-	helix-turn-helix domain-containing protein	F8J194	Lactobacillus_virus	9.2e-30	59.1
WP_023520385.1\|2590035_2590722_-	hypothetical protein	C9E2N1	Enterococcus_phage	3.7e-89	69.1
WP_023520386.1\|2590754_2591639_-	DUF1351 domain-containing protein	A0A0S2MYB3	Enterococcus_phage	6.6e-30	35.3
WP_023520387.1\|2591639_2592332_-	ERF family protein	A0A0S2MYH3	Enterococcus_phage	1.6e-42	41.3
WP_041684528.1\|2592910_2593126_-	hypothetical protein	NA	NA	NA	NA
WP_023520391.1\|2593192_2593420_-	hypothetical protein	NA	NA	NA	NA
WP_023520392.1\|2593431_2594157_-	ORF6C domain-containing protein	A0A1P8BKT1	Lactococcus_phage	4.7e-42	51.7
WP_023520393.1\|2594223_2594508_-	hypothetical protein	NA	NA	NA	NA
WP_023520394.1\|2594507_2594702_-	helix-turn-helix transcriptional regulator	D2IZW2	Enterococcus_phage	2.9e-07	42.9
WP_023520395.1\|2594805_2595009_+	hypothetical protein	NA	NA	NA	NA
WP_023520396.1\|2595005_2595212_-	hypothetical protein	NA	NA	NA	NA
WP_023520397.1\|2595515_2595863_+	helix-turn-helix transcriptional regulator	A0A126GGL0	Streptococcus_phage	6.8e-23	45.7
WP_023520398.1\|2595871_2596303_+	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_023520399.1\|2596360_2597500_+\|integrase	site-specific integrase	A0A1S5S7K9	Streptococcus_phage	2.0e-71	39.4
WP_010734285.1\|2597579_2597948_-	50S ribosomal protein L7/L12	NA	NA	NA	NA
2597575:2597594	attR	NA	NA	NA	NA
WP_010734284.1\|2598006_2598510_-	50S ribosomal protein L10	NA	NA	NA	NA
WP_010734283.1\|2598885_2599575_-	50S ribosomal protein L1	NA	NA	NA	NA
WP_010734282.1\|2599676_2600099_-	50S ribosomal protein L11	NA	NA	NA	NA
WP_010734281.1\|2600419_2601088_+	L-serine ammonia-lyase, iron-sulfur-dependent, subunit beta	NA	NA	NA	NA
WP_023520400.1\|2601103_2601976_+	L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha	NA	NA	NA	NA
WP_023520401.1\|2602089_2603400_-	amidohydrolase	NA	NA	NA	NA
WP_023520402.1\|2603396_2605121_-	amidohydrolase family protein	NA	NA	NA	NA
WP_023520403.1\|2605230_2606292_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_023520404.1\|2606314_2607355_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.0e-29	37.4
WP_010734275.1\|2607416_2608196_-	ABC transporter permease	NA	NA	NA	NA
WP_023520405.1\|2608188_2609025_-	ABC transporter permease	NA	NA	NA	NA
WP_051093532.1\|2609368_2610277_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_010734272.1\|2610339_2610885_-	transcription termination/antitermination protein NusG	NA	NA	NA	NA
WP_010734271.1\|2611256_2611418_+	hypothetical protein	NA	NA	NA	NA
WP_010734269.1\|2612565_2612736_-	preprotein translocase subunit SecE	NA	NA	NA	NA
WP_005878997.1\|2612753_2612906_-	50S ribosomal protein L33	NA	NA	NA	NA
WP_010734268.1\|2613064_2613709_+	CBS domain-containing protein	NA	NA	NA	NA
WP_019722317.1\|2613833_2614337_-	QueT transporter family protein	E7DN70	Pneumococcus_phage	1.7e-06	32.6
WP_023520408.1\|2615039_2616044_+	YegS/Rv2252/BmrU family lipid kinase	NA	NA	NA	NA
WP_010734265.1\|2616162_2618709_-	ATP-dependent RecD-like DNA helicase	A0A1P8DII4	Virus_Rctr197k	7.7e-39	34.6
WP_010734264.1\|2618727_2619381_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_010734263.1\|2619707_2620211_-\|tRNA	tRNA (cytidine(34)-2'-O)-methyltransferase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_022879

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NC_022879_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_022879_1

76794-76894

TypeV-U3

Consensus_repeat	Method
GTTTTAGAACCATATAAAACAGCATGGTTCTCAAAT	CRISPRCasFinder

1 spacers

c2c10_CAS-V-U3

The CRISPR arrays of NC_022879_1

>merge|NC_022879|1|76794-76894|CRISPRCasFinder
GTTTTAGAACCATATAAAACAGCATGGTTCTCAAATTTTTGTTTGCCTTTATTTTTGATGTTCGCGTTTTAGAACCATACAAAACAGCATGGTTCTCAAAT

>NC_022879|1|1|76794-76894|CRISPRCasFinder
GTTTTAGAACCATATAAAACAGCATGGTTCTCAAAT	TTTTGTTTGCCTTTATTTTTGATGTTCGC
GTTTTAGAACCATACAAAACAGCATGGTTCTCAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NC_022879.1\|WP_023520663.1\|70875_72378_+\|relaxase/mobilization-nuclease-domain-containing-protein	unknown	unknown	gnl\|CDD\|367497
NC_022879.1\|WP_023520677.1\|86231_86867_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NC_022879.1\|WP_023520660.1\|68311_69985_+\|hypothetical-protein	unknown	unknown	unknown
NC_022879.1\|WP_023520659.1\|64363_68296_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376215
NC_022879.1\|WP_023520674.1\|82981_84265_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|182121
NC_022879.1\|WP_041684689.1\|77628_77904_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NC_022879.1\|WP_023520671.1\|77928_78735_+\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
NC_022879.1\|WP_023520678.1\|87385_88720_+\|hypothetical-protein	unknown	unknown	unknown
NC_022879.1\|WP_023520673.1\|79911_82920_+\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
NC_022879.1\|WP_080674337.1\|73045_73855_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|376885
NC_022879.1\|WP_023520662.1\|70487_70874_+\|plasmid-mobilization-relaxosome-protein-MobC	unknown	unknown	gnl\|CDD\|368576
NC_022879.1\|WP_023520679.1\|89458_89827_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NC_022879.1\|WP_023520676.1\|85812_86163_+\|hypothetical-protein	unknown	unknown	unknown
NC_022879.1\|WP_023520675.1\|84314_85793_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|368260
NC_022879.1\|WP_041684687.1\|75512_76685_+\|hypothetical-protein	c2c10_CAS-V-U3	-	unknown
NC_022879.1\|WP_023520668.1\|74908_75121_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350588
NC_022879.1\|WP_023520665.1\|72666_73053_+\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	unknown	unknown	gnl\|CDD\|374224
NC_022879.1\|WP_023520672.1\|78826_79867_+\|DUF916-and-DUF3324-domain-containing-protein	unknown	unknown	gnl\|CDD\|371730
NC_022879.1\|WP_023520661.1\|69968_70250_+\|hypothetical-protein	unknown	unknown	unknown
NC_022879.1\|WP_023520664.1\|72443_72632_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942

Protein	Function_ID	Function_description	E-value
NC_022879.1\|WP_023520663.1\|70875_72378_+\|relaxase/mobilization-nuclease-domain-containing-protein	gnl\|CDD\|367497	pfam03432, Relaxase, Relaxase/Mobilisation nuclease domain. Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation. The relaxase, in conjunction with several auxiliary proteins, forms the relaxation complex or relaxosome. Relaxases nick duplex DNA in a specific manner by catalyzing trans-esterification.	1.01023e-28
NC_022879.1\|WP_023520677.1\|86231_86867_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	1.26882e-34
NC_022879.1\|WP_023520659.1\|64363_68296_+\|hypothetical-protein	gnl\|CDD\|376215	pfam18796, LPD1, Large polyvalent protein-associated domain 1. This is an alpha helical domain with a conserved ExxARxxE motif that is found in polyvalent proteins of both conjugative elements and phages and prophages.	6.15701e-09
NC_022879.1\|WP_023520674.1\|82981_84265_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|182121	PRK09863, PRK09863, putative frv operon regulatory protein; Provisional.	3.29882e-05
NC_022879.1\|WP_041684689.1\|77628_77904_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	0.000227285
NC_022879.1\|WP_023520672.1\|78826_79867_+\|DUF916-and-DUF3324-domain-containing-protein	gnl\|CDD\|371730	pfam11797, DUF3324, Protein of unknown function C-terminal (DUF3324). This family consists of several hypothetical bacterial proteins of unknown function.	2.4585e-67
NC_022879.1\|WP_023520673.1\|79911_82920_+\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	1.0725e-38
NC_022879.1\|WP_080674337.1\|73045_73855_+\|Fic-family-protein	gnl\|CDD\|376885	pfam02661, Fic, Fic/DOC family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.	0.00734042
NC_022879.1\|WP_023520662.1\|70487_70874_+\|plasmid-mobilization-relaxosome-protein-MobC	gnl\|CDD\|368576	pfam05713, MobC, Bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region. The absence of MobC has several different effects on oriT DNA. Site- and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency of mobilisation. The localized DNA strand separation required for this nicking is less affected, but becomes more sensitive to the level of active DNA gyrase in the cell. In addition, strand separation is not efficiently extended through the region containing the nick site. These effects suggest a model in which MobC acts as a molecular wedge for the relaxosome-induced melting of oriT DNA. The effect of MobC on strand separation may be partially complemented by the helical distortion induced by supercoiling. However, MobC extends the melted region through the nick site, thus providing the single-stranded substrate required for cleavage by MobA.	6.79658e-05
NC_022879.1\|WP_023520679.1\|89458_89827_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	0.00238251
NC_022879.1\|WP_023520675.1\|84314_85793_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|368260	pfam05043, Mga, Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins. This is presumably a DNA-binding domain.	7.43977e-07
NC_022879.1\|WP_023520671.1\|77928_78735_+\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	2.32011e-64
NC_022879.1\|WP_023520668.1\|74908_75121_+\|hypothetical-protein	gnl\|CDD\|350588	cd18513, BACK_KLHL3, BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3). KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.	0.00159092
NC_022879.1\|WP_023520665.1\|72666_73053_+\|type-II-toxin-antitoxin-system-HicB-family-antitoxin	gnl\|CDD\|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	5.81658e-10
NC_022879.1\|WP_023520664.1\|72443_72632_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	9.81476e-06

>NC_022879.1|WP_041684687.1|75512_76685_+|hypothetical-protein
MTKKIEVSIDGSQEEKNSFYDFFWKNSREYVKALNMVYKQLMFEELLKDAIKEMDQGYAEREKSIQDRIEKLGYNDPIDQKKLDKTKAELSKLRNEKNKEAREILTQAIGLKSQTRTRDVAKKMDFDYSDFIDSANMKASKDFGNDFIGIVSGQRTPRIYKNKNKYGLLPFRGRDIKIHKADKFYISLPKGFRFKVNLGSKPRKARDVASVLQYIAKGDYKLNQSNLIYDGRKLFFNLTFSFEKSYNELEFNEGTELIVNFVDLCSGECLVNNQTVISFGDSQYIRNFKSKIKAIKSKEQSRGIFSKGGHGRKRKLNQDRWEAIKSRESNFVKTYNNQCSAKIVKTAIRNKAQVICIAEPDKDYGEWAYYQLKEQLVNKGKRYGIEVKSI
>NC_022879.1|WP_023520668.1|74908_75121_+|hypothetical-protein
MAVWQIQLKERGAYGLISLSDVLCRKEMPDLFSLDQIIAIIGAAAVVITAIAKASDSVLAWLKFKKEQKK
>NC_022879.1|WP_080674337.1|73045_73855_+|Fic-family-protein
MSDNGGGQPMDTTALAKFIQSLGSLNNYGSSVYQTKKALDLKSTKPLRQNRDDIAIFVDSLKGINAIKEKGFSVDGIIEVNKQFDSPSEEQPKLPGHLRNSYYNEDDRIAIVLDQASQEHYFPKEIISRNDLQEIVDQFEQSERTEKDAWWVFARLAKLQAFQDGNKRTALISANAAYGTLDSENYLMVPFHDIKRLEFTFNLMSFYRAKDHLEEEQAFEGLYRTLPSKKERELYLRQPIEERNVGQDLSTFRVKSELRSTEKDNEPEL
>NC_022879.1|WP_023520665.1|72666_73053_+|type-II-toxin-antitoxin-system-HicB-family-antitoxin
MKKVYPAIFEKDPVGYGIYFPDIEGAVTQSEDIAQGLELAADALGIMLGDLVEKNMPLPTPTAINALSVNPETEFATLISVDLNDYLKDVQLDKKTIKIPHWLNVRATNEGINFSKTMTEALAQKLNV
>NC_022879.1|WP_023520664.1|72443_72632_+|type-II-toxin-antitoxin-system-HicA-family-toxin
MPMTIREAEKLLKDAGFVEVKGGKGSHRKFIKKNFPRPVILTSHSKELSRRVEDSVRKAVGK
>NC_022879.1|WP_023520663.1|70875_72378_+|relaxase/mobilization-nuclease-domain-containing-protein
MPTTKTLTIKQERYLKEAIRYILDPEKTKNQTLTSGHKVNAVNNAFFEMNLTRTLAQRVRGKMNKKKTEEVIARHIVQSFDPEDNLTPEEVHEIGRQTALEFLGEDYEFVIATHVDKEHLHNHIIFNTTSCVDLTKFRWQRGTAAHLRNYSDKVADYHGAMILDTPKRNSHKKYQEYRRKNAYRVELKERLNFLLTHSTSWDDFLVKARLLNIDVDPNHNSEEYGKVINYKLLDLPQKRPARDYTINKKQRIYNEENIIERVSKNKPEAVFNAMDIAKKYVEQKAEKESFPDLIFVIEPWQIQRDTMTGIYVEIAYGRYETGVVKVPDYMLEKLEDGRYEAHFNYKDIFYFWSDEKGQKNKFVKGASLANYLSGESGLFPKRKNSAIQNVREMVTALNILSTSQVSSDQLPHVLGKDFYDNYEIVQAARATLDDKLFRANEKLKYDPSNLEQIEKVKSLHGEKKELEKQVKLLEKQLKTYDAALSILTEKAVSDSVDLDK
>NC_022879.1|WP_023520662.1|70487_70874_+|plasmid-mobilization-relaxosome-protein-MobC
MRKKELFRSEFVQVYLTKEEKKRIKENMETSGLKTMTNYVRIMALNGLVVKIDFTTLRESLAETGQYVSELNMIGNNINQIAHKLNQTDIVETEDIQYLVSEFAKMQHNYVRSQDILLQEIQKLTRSE
>NC_022879.1|WP_023520661.1|69968_70250_+|hypothetical-protein
MIKLIKKRPLCQYYLWKVCQRFERDESQELILPPVKAVIGQLQSERRNLEKVEKESIALHISSLALLEEILKNESEQSFRKLISDLEEFGKGH
>NC_022879.1|WP_023520660.1|68311_69985_+|hypothetical-protein
MPTLFPDNYEIANIVKRKKLARNLKLKNELSALDIALHAHDIFDYLTGHGVEKLNSAFVSLFQYAAEALGVPYEIIEEAFFTQTPLSEEELFAVSYLFNPNAKIIDKQDLPIVPITIDFYSMCLSLFDELPASFWKDYVKAEALLPETKLDAYDLEKLLQAFVQQVWLKTKESIGKTEGNKIEKARQMFLAYFYRNDQKFYRKETQDMLLGLLENKIAEQVEEAFVIDDHFQKLLDEGASNSICSYVIDHLTDWTDEKNYLRFLRSIPKTKNLSLMNQLLLLYQRAEAVESKEVHDWIRENRTLKNNAEPVFLFGGNQQKVNSETGEILKEKQTLLTQTTHAPIVPYFEKTETQGKEETKKIETSPKEVFAILEKITNRTIVFEEREESILEDHTIRIKSNQGEEQTLADLIICLLEKEKRSVDDIIRFENESIASIVMIVFGFNPLPLNLSLLTQLRSMNNGKVKLQQLFADLIVRSDTFLQKIAAHMYEKETEPVRPTLEEEIRRARELQSRAMENVATDKANKKEERSEEEYNLADTLEKLKGNSESSEDDKTD
>NC_022879.1|WP_023520659.1|64363_68296_+|hypothetical-protein
MENQLTSLLKKKYGTTTSSPLVFTEKDTLYTAFRKLADNIYKNGTWTQEDELRAVDTFIRNRDGYPVGKEDATFHDWNGQPWSTEVKVRPIDVVESSFLRSEAEGKKIYSATAIRRKINGSEEHVKSVDVLLDPKNKSGTKHGDFYYFSSSNSTDPSYYALGSMNRAIGYDKLQRDILKEFDDTVQELKFDRRDLERLLERLSIASYTGKKNAHLFQKNPHGELTNTFLATLPRDEREKYLDNPSKMKSMLENNEVQGEERQWLEEQVAANWGDLSNDPTNPVKVNLDKSPYLLKEGNRTTYLYPETIQNARKQNELISFVEEYIQSTYDIFLQREYEKDIDKQTRASAWQTKKNINKDTRKIMESTSLNKYFQFVEIDNDVDLTLFSQFEKEMARMHDILPKTGDKLPELRLRKLGNHKALGLYVPNKNTIAIDFRDTNDEIGGVGIQSFVHEYGHALDYGTDNGRLLSMREDFKPIVTRYRENLSLNGKGSYVAEKAGYYTAPTEVFARAFELYVNEAGLNSIFLKSKETYATNIEYALFDQNMHDKLTTFFDSAFPNLKTAVLESNKEQIDVEQGTRSDQELLKTQVDTKIESIKSVKFIHENEELNVGDALETCELTLIDKASAIQKQEEAIHLYMNAIPQTDTMEQITAILKDSLEEMKEQSEETLFLFDGSELADYSTDLNEMLTMITERAVFNDVYGNSFQEVLLEVNGQAEQAHQNISAHAQALIDSKAVMPGEKNPTLYFVKGLKTVALELQETGDFLPSEKYKPQTETEKEVIGALLRKNEVGDIKVRRNHNNKIGNQPVERVQGVNDMAEVQVLEERKSKKYIELGNKIETLKKERIDFRYQSNWEKVSETDWELRKLNLAVETLDKNTIEPILSEIAEFEIDIAGLESIDRSNVNLEQYNSILERINRSKGYIKELKEMKDDYSNFYQQGLEEEIKSSPQGSNSLPKEEQQEQDQSSSIVSSNEQLQPSNHSFIQEINVSFDETKQEVDAFLKQVGYKGEQFGSMADIENILATHLKQVETIVKQSIEAVDALSVPTENQIQEETAKVKRTIGQILSDFKENLKQYVRTQKNNTVYQVTNTMDDIRLGLKNSFNRKLLSINGLLKKLSNTIDRKFVIEEKRNQAPLAKKMQEVQKKDSQELAQKEQEKVSESPVVSENQSTTVEPETQPTINTAESVSDQNKQHSEEPTLQNEPKLSDEGNIPVIAEEAEQSTAESTVTEAEKNQADKKMNNIELQQLKRIEDLSNQLGLNASAKQTETIKDLTQTQKSDLIRSMEVAVEEKNKSVSVKETETELEVG
>NC_022879.1|WP_041684689.1|77628_77904_+|LPXTG-cell-wall-anchor-domain-containing-protein
MSLIIAIQFPLQVYGTQVQSVESEGSIGFTGTYEPIGPPDPPPSTSPQKPGGTLPKTNMTGSSLGLWIGSFLVAGVLLVVGNKKRKETQEN
>NC_022879.1|WP_023520671.1|77928_78735_+|WxL-domain-containing-protein
MKFIRLATVAALSTTIFAGGVQVFAEDADQESKEVRKTTTTGQVTFTPNIEDTVVEPDPEGPEVTIPPIPGTGPLTIATVPTMNFGTKVISTADEHYNMIAEMQQKAGTTGEENMIPYVSMAQVQDTRGTNEGWELSVSLSEFQAKTDTLNSVLKGAKITLFDPSLRYSVNDANQEPTIHTSGLELIPSEEAVPVMTAANQKGGGTSSVVWGDHDALAKQVEDGVDVVENKAIQLFVPGSTAKDAVTYTSTLTWELELTPDNEEPDAV
>NC_022879.1|WP_023520672.1|78826_79867_+|DUF916-and-DUF3324-domain-containing-protein
MIHKQTIQKSLWLLIALFFFLPQAVQAEETSLNTYVTPLFPESQVDESKGYYELLLPPGQKETLRLEVGNSSSEPINVQVTPHTAYTNTLGNVEYGKDVEEADPSLIHSLDELMTPSEVIALAGNETKVIEIPLQMPKDAFEGYLAGGLRIAEVKEEEDSDAPGGEGVAIKNEFAHVVGVVVSNTRDSVQPELELLDVFADQLNYRNVISATLQNFTPTFVNQLAVEATVKRVGENEVLYKAEKEMMQMAPNSNFNFPISLEGDRFRSGNYVLELTATSGENEWSWTREFTIEAEEARKLNREDVMIDSGVNWWMIGSIILLILMLGLVLYLMWQKKRARESEKEV
>NC_022879.1|WP_023520673.1|79911_82920_+|WxL-domain-containing-protein
MKNKLCYLLSVISIGLLFIQVLIFPVASVSLSSVNAIDIQENQTELDGFSEEVLPNIPKLKEIEDLPLSFSTIDSTIVGKAGENIILSFHANKKINEATVKLPEEARIVEEDMPVGVTIEESKEANYWVIHSEKMQETFTFPVVFEEEGSYEAAIDEAKVQIYIQSMETISPDEQGETNVDKDESTEAEESKENKDTATGDQVEIDKAVSYISPEEGVAEVTNWTDFGQALGTPSITTIEVTKDFEVPTNSTVPGFITGVGSNPSGGAQFVYLTPANSSRKLVVNGNGHHIDFGSVSLVPMGATHNAQSPWDITFNDATIYSGNWWGFWSVQQGLSLAQQQISRIALKDVSVVGNQMLAPYYTHVDLYGKIDNHVVASYSSPFRTNFAVYTPNSINIESRSLTIKEDAVVNFSTLNSGNVVIGVGNQSGSLTLEKNATFNLESNGTLASANANAQTGSSIDIANGNLIMDEGSTINIDTTRNFAALTLRSTTSTLEVNDGAKFNIESTNHSFTGNGSNRNLVSMNAGSSLLVGSDAELNINAEGRGSASSSIIYVAGAANFKIAKDGSMDIKSDSNSINQNLLFFASANSIFEFSDAKKVNLERTNQISGSVTNGLINITGSTGQLDIDVQSVKQWNRDNFTEEPDYFWTPIFNLILRYNTINPTITNVSSIFQETMTSFNEAFTTRNVQRILFEKIPDVEITIDPLTEDALEVNSYTITGKASPHSVIRFSGDPAIPDGEIPSPNFSETDKYHVTADENGDYLYELPKDSLFTEGNEVTAYAYLNGKSATASTVVEKSRRPPNPKDPMNPEIEVDPENKPELEEDQGLLSIDFASRFTFGQQAISTRTKRYYAQPQRLLNPDGTVNEAEERPNYIQISDRRPEEERHGWQLAVTQNSQFTDLQENELRGARLFLTNQQLESMHGSEEPMLYNQDGVTLIPGEKTKLLTALDGQGAGTWIYRFGDGESASESVALEVPPTANPRASTYETTLTWELSVVPDN
>NC_022879.1|WP_023520674.1|82981_84265_+|helix-turn-helix-domain-containing-protein
MHILFDHLVMADKTKRWLLLLATLEEEEHVTAQTLAKQTGFGRRTIIEDIKAIKDYFGERIHLIGDEKGYHFSFLNPKEYYEKKQALLNEEKLFLFVDQLAAGKCLDNQQWMAYLDVSSASFQRMKRQLQTLLTTYYGIKIESKTNQLWGEEAGIRQFLYDFYFTLPLYPRFLSEHIQDLHQEKVAIQDGPWHLDQTLFNQWLKLAKQRVDQGHCLQEQVAHKQAQTTLIQALDQQVSVVLPGPEKAALFLLSLDESQFLNPLTQQAFTRTFSPASEYELPMHETEGLTYGFFETLLFLMEAFFQLPTLEAPEQVPYVNSEKPSPLEVLMKRFLAEKKKYSQTIYVSYQLVGPRALTRWIKQEVEMILKKSGLQVVEADQMNPLELVRHVQIVNQPQARNARETIELPYVPSKEKIEEVLSAFSESR
>NC_022879.1|WP_023520675.1|84314_85793_+|helix-turn-helix-domain-containing-protein
MREFQMAFITSAEVKRWMQVLSVMEQERRFTIGELSERLAISQRTLIKDIQTFKNHFGTSIELRSNYSGYYFEERNRRDYQEKKEQLLENEVLFEIVGNVFWGKDFTVADLAHQHSYAESTLRRFLSRIRPVLAEYELTLAFNPVNFLGEEANIRKFFFDFYYSSEQTPYTIRPPEDLHTLVLNELSGKLGKYELGTGITISAFYYQLYIAMVRVHQNHFVSLPEWLKVSIYQEKDFQLLYSLQERIKDEYEIYLSKEEFAWIHLSIISKRTIHRVDQEQTFNQRFNRWKDLQFIVSDYLSDPFFEQWDTDTLEPFMTSFFLSHLMNEAVSPVLNKELEEIHWMVKKSDKQIYEAHKQFLLKHARVLSFSAQYFEDIVVSFTAYMNLLFHYYQPVKKVLFLLEGDYLVVQSIRMQARVLLGEYHKLLFMPLQELTPEHLNDAYVDLIVTNYRPYLLDYALGTDYVLMGSIPTAQDWARVKHQLNPLIDHETF
>NC_022879.1|WP_023520676.1|85812_86163_+|hypothetical-protein
MPTFFTKEAYLEGFQSTFEEAEKRASEDLKVYLNTQIQRLETLVSQICQENFWELLPEILGIDAKMSLVVDLIDFDHCSDVEILRIVESDYLIYFKELCGYNRSMDPKHSMIFNVV
>NC_022879.1|WP_023520677.1|86231_86867_-|recombinase-family-protein
MKIAYIRVSSIDQNEQRQIEEMKKYGAEKIFIEKQSGATITHRPIFQDALGFVLEQDIFIVEAIDRLGRNYDEIINSVNYLKKKNVQLIITSLPIMAEAIGNPLLDKFIKDLIIQILAMIAEQERTESKRRLAQGIKIAKANGVYKGRPKLYSADTKDPQRRLVYKSIVEDLDNGVAISRIAKDYNITRQTVYRIKNEINNKNTYIKTNNH
>NC_022879.1|WP_023520678.1|87385_88720_+|hypothetical-protein
MISNKEEKKLIAEIDKKRTEYMKSKRYGKDICELFLQNFNFKGNTLDKLDVQKEIFPLVKQAIESYPEELQHRNIDLIKSSLDRSYYASQNATLLSHYTDQLINHNDDSFLVVPTGFKTKTGAHEVSCIIKKVGEEIQVEIFDKAGASPPERFEKSNENFNNYGKNYIVSNYFYKIDNTPDGINSMAKAIASGFTDRGFEPSDIKYQPLHFLSKIANSEYYGRNVTSSQYIQGNCLMKEVVASLKSVLSEKSSPGQLIFSTDKQGRTDSLNGILTEVACFRLEKMGYGTDISNYLREQYKMYCYLKDDRNKYPEDIKVMRKIENGKILNKHFTNSIPEFKRVASYNIEASFYNNKKKNLLSRFKKFIKLEGTKVRANQLTKEEITVIRSNVNDIRKNLEKDKEKINRNFNNIKEKALTMSMFIEPNVSRGSVRNSSVKSHNVRD
>NC_022879.1|WP_023520679.1|89458_89827_+|LPXTG-cell-wall-anchor-domain-containing-protein
MERKNRYILSIGMLLIHVYAPLVVHGTEIRSVETEGTIGFTGLYEIPGTPEPAPEGAIKQDLPKEIAQHPSMVNHSISRRLPKTNESQKRIWSTSGLLLVSTILGFWFWRHKKKKTNKESRI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	NC_022879	Enterococcus mundtii QU 25 plasmid pQY182, complete sequence	76830-76858	0	1.0
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	MK047642	Phage NG55, complete genome	14604-14632	6	0.793
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	NZ_CP016482	Synechococcus sp. PCC 7117 plasmid unnamed5, complete sequence	189235-189263	7	0.759
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	MH972261	Staphylococcus phage Pike, complete genome	16586-16614	7	0.759
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	MH972263	Staphylococcus phage JBug18, complete genome	16666-16694	7	0.759
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	NC_047813	Staphylococcus phage Andhra, complete genome	16675-16703	7	0.759
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	MK774614	Aeromonas phage CF8, complete genome	15694-15722	7	0.759
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	NC_047814	Staphylococcus phage St 134, complete genome	16511-16539	7	0.759
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	MH972262	Staphylococcus phage Pontiff, complete genome	16576-16604	7	0.759
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	NC_010480	Synechococcus sp. PCC 7002 plasmid pAQ6, complete sequence	112830-112858	7	0.759
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	NZ_CP016476	Synechococcus sp. PCC 7003 plasmid unnamed2, complete sequence	50512-50540	7	0.759
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	NZ_CP018030	Alteromonas mediterranea strain RG65 plasmid MRG65-300, complete sequence	97520-97548	7	0.759
NC_022879_1	1.1\|76830\|29\|NC_022879\|CRISPRCasFinder	76830-76858	29	MN855708	Bacteriophage sp. isolate 30, complete genome	1769-1797	7	0.759

1. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to NC_022879 (Enterococcus mundtii QU 25 plasmid pQY182, complete sequence) position: , mismatch: 0, identity: 1.0

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
ttttgtttgcctttatttttgatgttcgc	Protospacer
*****************************

2. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to MK047642 (Phage NG55, complete genome) position: , mismatch: 6, identity: 0.793

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
ctttgtttgcctttattttttatgtggta	Protospacer
.******************* ****

3. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to NZ_CP016482 (Synechococcus sp. PCC 7117 plasmid unnamed5, complete sequence) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
ttttgtttgactttatttttgaggaatct	Protospacer
********* ************ *  . .

4. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to MH972261 (Staphylococcus phage Pike, complete genome) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
aattgtttgcgtttatttttgatattaat	Protospacer
  ******** ************.** ..

5. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to MH972263 (Staphylococcus phage JBug18, complete genome) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
aattgtttgcgtttatttttgatattaat	Protospacer
  ******** ************.** ..

6. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to NC_047813 (Staphylococcus phage Andhra, complete genome) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
aattgtttgcatttatttttgatattaat	Protospacer
  ******** ************.** ..

7. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to MK774614 (Aeromonas phage CF8, complete genome) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
cgttggttgcatttatttttgatgttgca	Protospacer
. *** **** ***************

8. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to NC_047814 (Staphylococcus phage St 134, complete genome) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
aattgtttgcgtttatttttgatattaat	Protospacer
  ******** ************.** ..

9. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to MH972262 (Staphylococcus phage Pontiff, complete genome) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
aattgtttgcgtttatttttgatattaat	Protospacer
  ******** ************.** ..

10. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to NC_010480 (Synechococcus sp. PCC 7002 plasmid pAQ6, complete sequence) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
ttttgtttgactttatttttgaggaatct	Protospacer
********* ************ *  . .

11. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to NZ_CP016476 (Synechococcus sp. PCC 7003 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
ttttgtttgactttatttttgaggaatct	Protospacer
********* ************ *  . .

12. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to NZ_CP018030 (Alteromonas mediterranea strain RG65 plasmid MRG65-300, complete sequence) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
ttttgtttgattttatttttgatatctaa	Protospacer
********* .************.*...

13. spacer 1.1|76830|29|NC_022879|CRISPRCasFinder matches to MN855708 (Bacteriophage sp. isolate 30, complete genome) position: , mismatch: 7, identity: 0.759

ttttgtttgcctttatttttgatgttcgc	CRISPR spacer
atttgtttacctttatttttgaagctata	Protospacer
 *******.************* *.*

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_022878

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_022879

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection