CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP007172	Listeria ivanovii WSLC3009 chromosome, complete genome	5 crisprs	DinG,cas3,WYL,DEDDh,csa3	0	2	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP007172_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP007172_1

506867-507153

Orphan

I-A

Consensus_repeat	Method
GTTTTAATTACTTATTGTGAAATGTAAAT	PILER-CR
GTTTTAATTACTTATTGTGAAATGTAAAT	CRISPRCasFinder
GTTTTAATTACTTATTNTGAAATGTAAAT	CRT

4 spacers

The CRISPR arrays of NZ_CP007172_1

>merge|NZ_CP007172|1|506867-507153|PILER-CR,CRISPRCasFinder,CRT
GTTTTAATTACTTATTGTGAAATGTAAATCTGTATAAATTTCATCCGATGAATTTCGACATCGTGTTTTAATTACTTATTGTGAAATGTAAATAAATCGTTGTGAGATAATTATTTCAGATTGAGAATTGTTTTAATTACTTATTGTGAAATGTAAATGTGATAGAAATGTGAGGACTATCCGTTGCCACGCCAGTTTTAATTACTTATTATGAAATGTAAATACATACAAAGCGGTTTGGAAATTTTCTGAACCAACGTTTTAACTACTCATGATGAAAAGTAAAT

>NZ_CP007172|1|1|506867-507089|PILER-CR
GTTTTAATTACTTATTGTGAAATGTAAAT	CTGTATAAATTTCATCCGATGAATTTCGACATCGT
GTTTTAATTACTTATTGTGAAATGTAAAT	AAATCGTTGTGAGATAATTATTTCAGATTGAGAATT
GTTTTAATTACTTATTGTGAAATGTAAAT	GTGATAGAAATGTGAGGACTATCCGTTGCCACGCCA
GTTTTAATTACTTATTATGAAATGTAAAT

>NZ_CP007172|1|1|506867-507153|CRISPRCasFinder
GTTTTAATTACTTATTGTGAAATGTAAAT	CTGTATAAATTTCATCCGATGAATTTCGACATCGT
GTTTTAATTACTTATTGTGAAATGTAAAT	AAATCGTTGTGAGATAATTATTTCAGATTGAGAATT
GTTTTAATTACTTATTGTGAAATGTAAAT	GTGATAGAAATGTGAGGACTATCCGTTGCCACGCCA
GTTTTAATTACTTATTATGAAATGTAAAT	ACATACAAAGCGGTTTGGAAATTTTCTGAACCAAC
GTTTTAACTACTCATGATGAAAAGTAAAT

>NZ_CP007172|1|1|506867-507153|CRT
GTTTTAATTACTTATTGTGAAATGTAAAT	CTGTATAAATTTCATCCGATGAATTTCGACATCGT
GTTTTAATTACTTATTGTGAAATGTAAAT	AAATCGTTGTGAGATAATTATTTCAGATTGAGAATT
GTTTTAATTACTTATTGTGAAATGTAAAT	GTGATAGAAATGTGAGGACTATCCGTTGCCACGCCA
GTTTTAATTACTTATTATGAAATGTAAAT	ACATACAAAGCGGTTTGGAAATTTTCTGAACCAAC
GTTTTAACTACTCATGATGAAAAGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007172.1\|WP_014091929.1\|502896_503943_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_CP007172.1\|WP_003745619.1\|501841_502240_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_003721293.1\|503959_504253_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NZ_CP007172.1\|WP_014091937.1\|512151_512964_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_CP007172.1\|WP_014091940.1\|514601_516041_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_014091939.1\|513795_514605_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223550
NZ_CP007172.1\|WP_014091936.1\|511685_512117_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP007172.1\|WP_003745616.1\|500726_501329_+\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223865
NZ_CP007172.1\|WP_014091931.1\|507231_507819_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239632
NZ_CP007172.1\|WP_014091938.1\|513311_513695_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_014091933.1\|508588_508948_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131113
NZ_CP007172.1\|WP_014091932.1\|507889_508570_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_CP007172.1\|WP_003745629.1\|504267_505539_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CP007172.1\|WP_014091928.1\|502250_502892_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NZ_CP007172.1\|WP_014091930.1\|505676_506612_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_CP007172.1\|WP_014091925.1\|497903_498554_+\|transaldolase	unknown	unknown	gnl\|CDD\|223254
NZ_CP007172.1\|WP_014091935.1\|509783_511595_+\|LapB-repeat-containing-protein	unknown	unknown	gnl\|CDD\|380190
NZ_CP007172.1\|WP_014091934.1\|508954_509413_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP007172.1\|WP_003745617.1\|501356_501824_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129
NZ_CP007172.1\|WP_014091926.1\|498662_500723_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234

Protein	Function_ID	Function_description	E-value
NZ_CP007172.1\|WP_014091929.1\|502896_503943_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	0
NZ_CP007172.1\|WP_003721293.1\|503959_504253_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	3.06007e-27
NZ_CP007172.1\|WP_014091937.1\|512151_512964_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	8.03215e-47
NZ_CP007172.1\|WP_014091939.1\|513795_514605_+\|hypothetical-protein	gnl\|CDD\|223550	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism].	0.00941667
NZ_CP007172.1\|WP_014091936.1\|511685_512117_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	8.50199e-27
NZ_CP007172.1\|WP_003745616.1\|500726_501329_+\|SIS-domain-containing-protein	gnl\|CDD\|223865	COG0794, GutQ, Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane].	2.76623e-74
NZ_CP007172.1\|WP_014091931.1\|507231_507819_+\|hypothetical-protein	gnl\|CDD\|239632	cd03577, NTR_TIMP_like, NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. This group contains domains similar to the TIMP NTR domain, which binds MMPs. Members of this group may or may not function as MMP inhibitors.	0.00090237
NZ_CP007172.1\|WP_014091933.1\|508588_508948_-\|hypothetical-protein	gnl\|CDD\|131113	TIGR02058, lin0512_fam, conserved hypothetical protein. This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N-terminus. [Hypothetical proteins, Conserved].	1.27104e-62
NZ_CP007172.1\|WP_014091932.1\|507889_508570_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	1.59831e-55
NZ_CP007172.1\|WP_003745629.1\|504267_505539_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	1.69818e-176
NZ_CP007172.1\|WP_014091928.1\|502250_502892_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	3.06567e-107
NZ_CP007172.1\|WP_014091930.1\|505676_506612_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	3.51918e-155
NZ_CP007172.1\|WP_014091925.1\|497903_498554_+\|transaldolase	gnl\|CDD\|223254	COG0176, MipB, Transaldolase [Carbohydrate transport and metabolism].	6.02657e-58
NZ_CP007172.1\|WP_014091935.1\|509783_511595_+\|LapB-repeat-containing-protein	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	1.36422e-122
NZ_CP007172.1\|WP_014091934.1\|508954_509413_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	6.60145e-13
NZ_CP007172.1\|WP_003745617.1\|501356_501824_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	5.60445e-35
NZ_CP007172.1\|WP_014091926.1\|498662_500723_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	3.69027e-75

>NZ_CP007172.1|WP_014091930.1|505676_506612_+|ribose-phosphate-pyrophosphokinase
MVRKMKLFSVTSERPLATKIADYLDIPLCEVELQKFSDGEVKINIEESIRGTNAYVVQSMNANVNERLMELLIMVDALKRASVHSINIIMPYYGYARQDRKARSREPITAKLMANLIQRAGADRLITVDLHAAQIQGFFNIPIDHLSAVPLIGDYLIEKYGEEDVVVVAPDHSGVVRARRIADRLDAPIAILNRKPRPHEDEIMSVIGDVKGKVAIVVDDIIDTGVRATTSADVLLEKGAVEVIACATHSVMAGDATERLQNSPIKEIIISDSIDLPEDKQFEKLTTISIGRILGRAIEGVQENRSLHPLF
>NZ_CP007172.1|WP_003745629.1|504267_505539_+|PTS-galactitol-transporter-subunit-IIC
MDIILDFFKYIIGLGVTVMMPIIITILGVIFRKKISVAFKAGLTVGVGFVGLGVITSLMLTTITPVTKALVENYNFKLTATDIGWGVGSSLAWGTEVVPFVFVAIIATNIVMIAFKWTKTMDVDIWNYWQPLFIASALYLTTGSMAIAVFSSIINMAIIFKIADWTQKDVENVLGLEGISLPQIQTTGWALVGYPMNWLIGKIPGVRKINWSTEKVQSRLGIFGEPMLMGLIIGGGLAAIAQMPLSQVLQTGVTIAASLVLIPRMVSLLMDGLTVISEAAHEFMEKRFPGRELFIGLDSAVGIGHPFVLSLGLLMIPITLVLAFILPGNKVLPLADLTALPFYMIFAIVPSKGNLFRGIFTGIVIVIITLYLSGAAAPLMTELAGQIGYNIPKDAVEVTSLAVGTQWYTWIVYYGLHWFGGIL
>NZ_CP007172.1|WP_003721293.1|503959_504253_+|PTS-sugar-transporter-subunit-IIB
MKKKRIYVCCGTGIATSTVISKKVRAVLDEKRIPYEISQCTVQEVASKVSTSKPDIIVSSTTVTGDVGDVPVVIGRSFLTGLKKQETIDEILAILQD
>NZ_CP007172.1|WP_014091929.1|502896_503943_+|galactitol-1-phosphate-5-dehydrogenase
MKALKLYGKRDLRYEEADMPTIENPDEVILKVKTVGICGSDISRYSKLGPYVPGMVWGHEFSGEVIEVGSAVKDITIGDRAAGCPALYCGECEYCKKGEFARCRKLTVIGARHPGAYAEYIKLPAENVVKIPDELDYEAAALVEPSAVVVHGYYHTKLQAGDDVVVVGSGNIGLLAIQWAKIFGARKVIAIDVDDKKLAQAKEVGADVVINSLKEDPLEVVAAHTDDLNADLVVEAAGSPITSAQVFAYAKKGGGVVFLGIPYADVTIERFYFEKIVRSELTVWGSWNAISAPFPGKEWQTTIHFLANKQINIEPMITHRLSLKEGPEVFERIYARNEFFGKVLFFPE
>NZ_CP007172.1|WP_014091928.1|502250_502892_+|ribulose-phosphate-3-epimerase
MAKIVPSVFGADIGRINEQLQVLEKNGIDLLHVDMMDGSFVPNIAFGPDQIKMMKKGTKLQFDVHMMVYEPDRYIPRLVEAGAHMITVHQEATTHLHRTIQLIKSYGVRAGVVLNPGTPPSTLEYVLDDLDCILLMTVNPGLGGQTFFQSSLEKIRKTKAYIGDRPIQIEVDGGVNAELAKECTLAGADLIVVGSYLFEGGIEANLAELAKGV
>NZ_CP007172.1|WP_003745619.1|501841_502240_+|hypothetical-protein
MGNFFASFVNWLIGSPGRFVVQLIENNMLIFMLFAMLYTTTILYAKWTLTYYLPKKMYQLAKMKTWELEELHEAWQTEKKSLPWYILVPSRNEFWVKSAKNAPESTKLLHFSQQKLKLSDKEKLQKIIEIQS
>NZ_CP007172.1|WP_003745617.1|501356_501824_+|PTS-sugar-transporter-subunit-IIA
MDVLEYFKEEMVLFSNEQDKENLLSEMAEQLIQVGAVKPSFKEAVIKREAVFPTGLLTAHAGVAIPHTDSEHVIRPVIAVRILETPVSFIEMASDNEAIEVKVVFMMALKSADEQLDMLQTLIQLIQDEEVMTTLLEAKETTNVLTAIEQFSRNT
>NZ_CP007172.1|WP_003745616.1|500726_501329_+|SIS-domain-containing-protein
MDKQAILENIHSTWREEAEAILRLPEVTNENALIETVEKIANCTGKIVVSGCGTSGVAAKKLVHSFNCIERPAVFLTPSDAVHGTLGVLQQDDILILISKGGNTGELLNLIPACKTKGSTLIGVTENPESVIAKEADIFFPVSVAKEPDPFNMLATASTMTVIASFDAIIVCLMTYMNYTKEQFSVIHPGGAVGNKLLNK
>NZ_CP007172.1|WP_014091926.1|498662_500723_+|BglG-family-transcription-antiterminator
MYLDNRSKTLFQEVIKNPNITNKQLEVKYKLSRYQISYSFQKVNEWLKWKNYPEVKRSKNGKFILEPELTTLFSEKETRDPSVEYLPSENERANLILLMLLTAKEELSLAHFTTKIQVSKNTILRDLKVAQKLLPAETTVTYSRASGYQLAGSEWELRKVLTQVVSSVKEMFRGEHYFLSYSGIEQAQLMEIRRTLEEAEAIMQIKFTYEQIELLPYLLSVMFLRIRDRRLIYTAFQIDEKSLSDTREYHITDILLEKTGPVPEQERLFITLQLLTTNIFSGEILTERLTEDLEKVVLTCLDLFEKKALVSLKNKHILIEKLLLHLKPAYYRIKYQMNLEDNLYEKFNQEFEALNFIVKEAFAPLARFIGHEIPAGEIFFISLFIGSDMIPQNDIYHQQKRAIVLCPSGVTFSKIMENILVKLFPEIHFYPTISVREYAFFKAEVDIVFSSIPLKDAENVFVVQPFISDIEKTQLRQHVLERLFGMSNQLTSMDKIMDIVERNADISDESAIREGIIDILSANTATKENRRVKKVYLHDLITEENIMICDDVKNYQEAIRLASQPLLLQQAITANYVKTMINNHNFYDPYIIIGEDIAIPHAMPNAGVNRLAMSLLVVKNGVYFSETEQVHFIIVIAPVDKEQHIEALYQIVHLAENDTMLANLLKNVTKAKIMQTIDQLIIREDE
>NZ_CP007172.1|WP_014091925.1|497903_498554_+|transaldolase
MHLDSGNLEDIKKIQASSIFKGITTNPSILVKEKCSRKTAITNILQQSNKLVFVQTVGFTYEEILADASALLATFGKERIAIKIPAHEDGIYVIETLKKEDKTIKLLGTAIYSADQAIAAGLAGADFVAPYVNRMSGASINPFKEIAKMRHFFDKQALSTQIMAASFKNAGQVMEAYESGADTVTIPYDIYEQMTNKVLAIEAIHVFNQDATLFES
>NZ_CP007172.1|WP_014091931.1|507231_507819_+|hypothetical-protein
MKKALCPILLLLILLASCSTQDETLSPNTKIHKNSVIRADYKIPQNLAELESDSEDIVQVKLIRNKEIGKGNNSSITEVEIIKNYKGSFEPGDKVDISEPWLLTSGEYQAVENYIALEKGQEYILFLSGGHGTDKVSSITSLGYGKYNKSLQEQKADMNDFNTVGEVQKYDFISGLEAEIIKYQEIKKEMLKTYN
>NZ_CP007172.1|WP_014091932.1|507889_508570_+|type-1-glutamine-amidotransferase
MIIDVLQHVSHEGPGLITKWAKENQHQLRIHCLFSESNHVPTNSEFLIVLGGPMGVNDTAEFPWLKEERNLIKRLINQEKPVFGVCLGAQQIATALESNISINDEKEVGWFPVNRTSTKLPFFPEKLDVFHWHQETFSLPNGATRLFSSEGCVNQGFLYGEKIIGLQFHFEMEKAGIETILQIDEEFITPGKFVQSVAEMRERDVPEDNKQMLEAILDYLVAEKNI
>NZ_CP007172.1|WP_014091933.1|508588_508948_-|hypothetical-protein
MEKLLFIQTGFGVDVHGQDITKAAERAVRNAIFTNSMPGIRSQLPDNRLENMVVNIKLALPCDADELDEEVIRAIIPYGTVTIETMPGGMLTTSGIFLEDKADKNDLMYIVNASVETGY
>NZ_CP007172.1|WP_014091934.1|508954_509413_-|winged-helix-turn-helix-transcriptional-regulator
MNNEQSMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERQLLTIEQGTRDKRQRCIFLTTAGKELENELGAAQRKQMAQIFAESTDTNGIHFTDVMTGYAKNRPGAALIKDFKE
>NZ_CP007172.1|WP_014091935.1|509783_511595_+|LapB-repeat-containing-protein
MKRLFKLLLTLACVVSLTYPTLTAFAEENSSGNSVVNIPDTALKTYLNSQLKQASDADITADQMALIKSVTITGTNYTDLTGLEAAVNLNTLNISNTNITTLNPIRTLTTLNYLNVSGDVITDSFFPDLNQLTNLENISISSKNVTHNVFTKFNKLPKLRFLYAQNSMLITDISGLASLENLETLFLQFDGIDDFRPLNDFASFKNGKLKSLAAYGQNMGRTNPRITLKSGKLNYNATDQTLYLPFSMMPNQLTSFDGTVAPFSKSTSASNTYVGFNDVAVASSRLSITDDGITISGVTKEEFDGLTELEYNARFDFPTGSYPTPPSMTSYTISAGTYDQYFDISHTLDLTADESIGYNQYTLATEGQFLKAIHAETDDGTAVQSNFDQVVDFNTPGEYTVTLNAENSAGLKADPLEVKVTIYAKPIIKADSSISYEQKTTKTAEEFLTETHSSVTENAALTSDFNDVVDLNTPGEYTVTLNAENERGQKADPVQIIVTVTAKADPEQPVPPTKEKPTTEKPADNKSVATKEPTKATEKNKKSEESPSNLTTKENTEPTTKEVTKTTEQKLPKTGDAGLGTWPVAFTSIMMGLMAIILLKKRK
>NZ_CP007172.1|WP_014091936.1|511685_512117_+|universal-stress-protein
MDKYNRILVAIDGSEPAKLAFEKGLELALKLDGVLGIASIVDIRAFSPNVSYDGSLEEKAELELKGNVNEYAEEARAKGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NZ_CP007172.1|WP_014091937.1|512151_512964_-|histidine-phosphatase-family-protein
MKKNILKAMVMFCALLLIAGCGNDSTTSKADTTEKKDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVTSAGKGLKDVDFGAAYSSDSGRAIQTANLILEESAKSSDTKLQTDARFREFNFGSYEGDLNHNMWTDIAKSQGKTLEEWQSAGISPKIFADSVAKLDKTRVKEGENWPAEDYATIQARLKNGITEVAKKESKKGDENVLLVSHGLSIGALLDTIEPGYKLPATGIKNASVTKITYKDGKFKIEDVNDMSYAEKGQE
>NZ_CP007172.1|WP_014091938.1|513311_513695_+|hypothetical-protein
MKKKLLIISGVLIMVLFASVSYVQAGSTYANYSTTVGKFNGNGYTAYQTKKVAGQKANVKSTKTGGYKLNVRTNSAGSNGTWSADFTNSKNIDLSNGHNKGTKTRLHFSNKITTTRDVQASGSWRSN
>NZ_CP007172.1|WP_014091939.1|513795_514605_+|hypothetical-protein
MQSMIKKELKEYITITNILIIIIGSLAPTLYILSQANNQTYLHWLGLYSNSVGSFQALLFPLFIVILTIPKLSTKLSNKFISYVRIRKNIYQYLGATMISNAIIVFVGSFLLVFIPFIITYYIVPIFGLIGYQPESMGLNTVAAINNDIATNDALSFLINVSPLFYAIVYAAWVGFNGILWYIVSWCLLIIKNNIFLALSIPFVVYQIAHFLFSLLGVPQFGSLISIFPFNFEKVPVWNMLLFPMLLIVGVISMLIYIYKNIEKMDSLS
>NZ_CP007172.1|WP_014091940.1|514601_516041_+|hypothetical-protein
MSLAKITNTFINVKNLSIFSIASLYGILALQGSFNQYNMNFAERSVSLLSDPYLFIYFILPIWIMLVSKEILTRKDYQNTIRLKTKQRYNLWLLRKCMLISFSLITVLLISSICISVGGDVKLTWSSHIANYQETGLIVSVLNDLISSPISAILVQLLVYFIFLSTIAYFIITITYKIHTPIFIYCVSLLILIYMMYTFTFAMEPLYMNISSLAFAYRVLGQLSQEIIVYTVILVTCILLNTNKVLRKINDLYMYQKKHIIFLAVILVSYVFLGINGADLSINDYIISTNYGSSNEGYTINSILFYAIIYLGIPYLILLGINEKQQLIYYELIRQKTMNKWIFKNILAALQYSCLYLMVTFLIMIGTSYKNYQELLSIDGEILYQYFINGSLQIFFYSLIILLTYSITGKITYALYLNLGLIILLLPVININHILPIGLNAMGMLEDRTPYQLSLQLLIAILMITMILILVNRKRTIPQ

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Crispr_ID: NZ_CP007172_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP007172_2

516141-516753

Orphan

I-A

Consensus_repeat	Method
GTTTTAATTACTTATTATGAAATGTAAAT	PILER-CR
GTTTTAATTACTTATTATGAAATGTAAAT	CRISPRCasFinder
GTTTTAATTACTTATTATGAAATGTAAAT	CRT

9 spacers

The CRISPR arrays of NZ_CP007172_2

>merge|NZ_CP007172|2|516141-516753|PILER-CR,CRISPRCasFinder,CRT
GTTTTAATTACTTATTATGAAATGTAAATAACGACGAAATGAACAAGTTATATAAAAAACATCCAGGTTTTAATTACTTATTATGAAATGTAAATTCAATTCCCTTGTTCGCTATAAACGGATGGAATAAAGTTTTAATTACTTATTATGAAATGTAAATAGCTTCCTTTTTTTAAGAAATTAGCAACATTTTCAGCGTTTTAATTACTTATTATGAAATGTAAATGGAGGAACAGCGACCGGTTTCGGCTCGGATATTAGTTTTAATTACTTATTATGAAATGTAAATTAGCTTTGCATTTTTTCAGTGATAGAAGTCGCATATGTTTTAATTACTTATTATGAAATGTAAATCCACATATAAAATTACGCCTCCTAATTTTAGTAATGTTTTAATTACTTATTATGAAATGTAAATAACGATATTGGTACAAAAGTAAATTTATCGTTTTTGTTTTAATTACTTATTATGAAATGTAAATAATATCATAGATGCGACTACAACGCCGTCTGACACGGTTTTAATTACTTATTATGAAATGTAAATGTCAAATTGCTCATTGAAATAAAGCGGGTTTGTGATTGTTTTAATTACTTATTATAAAATGTAAAT

>NZ_CP007172|2|2|516141-516753|PILER-CR
GTTTTAATTACTTATTATGAAATGTAAAT	AACGACGAAATGAACAAGTTATATAAAAAACATCCAG
GTTTTAATTACTTATTATGAAATGTAAAT	TCAATTCCCTTGTTCGCTATAAACGGATGGAATAAA
GTTTTAATTACTTATTATGAAATGTAAAT	AGCTTCCTTTTTTTAAGAAATTAGCAACATTTTCAGC
GTTTTAATTACTTATTATGAAATGTAAAT	GGAGGAACAGCGACCGGTTTCGGCTCGGATATTA
GTTTTAATTACTTATTATGAAATGTAAAT	TAGCTTTGCATTTTTTCAGTGATAGAAGTCGCATAT
GTTTTAATTACTTATTATGAAATGTAAAT	CCACATATAAAATTACGCCTCCTAATTTTAGTAAT
GTTTTAATTACTTATTATGAAATGTAAAT	AACGATATTGGTACAAAAGTAAATTTATCGTTTTT
GTTTTAATTACTTATTATGAAATGTAAAT	AATATCATAGATGCGACTACAACGCCGTCTGACACG
GTTTTAATTACTTATTATGAAATGTAAAT	GTCAAATTGCTCATTGAAATAAAGCGGGTTTGTGATT
GTTTTAATTACTTATTATAAAATGTAAAT

>NZ_CP007172|2|2|516141-516753|CRISPRCasFinder
GTTTTAATTACTTATTATGAAATGTAAAT	AACGACGAAATGAACAAGTTATATAAAAAACATCCAG
GTTTTAATTACTTATTATGAAATGTAAAT	TCAATTCCCTTGTTCGCTATAAACGGATGGAATAAA
GTTTTAATTACTTATTATGAAATGTAAAT	AGCTTCCTTTTTTTAAGAAATTAGCAACATTTTCAGC
GTTTTAATTACTTATTATGAAATGTAAAT	GGAGGAACAGCGACCGGTTTCGGCTCGGATATTA
GTTTTAATTACTTATTATGAAATGTAAAT	TAGCTTTGCATTTTTTCAGTGATAGAAGTCGCATAT
GTTTTAATTACTTATTATGAAATGTAAAT	CCACATATAAAATTACGCCTCCTAATTTTAGTAAT
GTTTTAATTACTTATTATGAAATGTAAAT	AACGATATTGGTACAAAAGTAAATTTATCGTTTTT
GTTTTAATTACTTATTATGAAATGTAAAT	AATATCATAGATGCGACTACAACGCCGTCTGACACG
GTTTTAATTACTTATTATGAAATGTAAAT	GTCAAATTGCTCATTGAAATAAAGCGGGTTTGTGATT
GTTTTAATTACTTATTATAAAATGTAAAT

>NZ_CP007172|2|2|516141-516753|CRT
GTTTTAATTACTTATTATGAAATGTAAAT	AACGACGAAATGAACAAGTTATATAAAAAACATCCAG
GTTTTAATTACTTATTATGAAATGTAAAT	TCAATTCCCTTGTTCGCTATAAACGGATGGAATAAA
GTTTTAATTACTTATTATGAAATGTAAAT	AGCTTCCTTTTTTTAAGAAATTAGCAACATTTTCAGC
GTTTTAATTACTTATTATGAAATGTAAAT	GGAGGAACAGCGACCGGTTTCGGCTCGGATATTA
GTTTTAATTACTTATTATGAAATGTAAAT	TAGCTTTGCATTTTTTCAGTGATAGAAGTCGCATAT
GTTTTAATTACTTATTATGAAATGTAAAT	CCACATATAAAATTACGCCTCCTAATTTTAGTAAT
GTTTTAATTACTTATTATGAAATGTAAAT	AACGATATTGGTACAAAAGTAAATTTATCGTTTTT
GTTTTAATTACTTATTATGAAATGTAAAT	AATATCATAGATGCGACTACAACGCCGTCTGACACG
GTTTTAATTACTTATTATGAAATGTAAAT	GTCAAATTGCTCATTGAAATAAAGCGGGTTTGTGATT
GTTTTAATTACTTATTATAAAATGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007172.1\|WP_025279758.1\|525247_526120_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP007172.1\|WP_025279755.1\|517360_518605_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270452
NZ_CP007172.1\|WP_014091937.1\|512151_512964_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_CP007172.1\|WP_014091955.1\|522871_523738_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP007172.1\|WP_014091952.1\|518683_519574_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP007172.1\|WP_014091936.1\|511685_512117_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP007172.1\|WP_014091959.1\|528074_528452_-\|DUF1304-domain-containing-protein	unknown	unknown	gnl\|CDD\|226282
NZ_CP007172.1\|WP_014091958.1\|526241_527990_+\|mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|380413
NZ_CP007172.1\|WP_014091931.1\|507231_507819_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239632
NZ_CP007172.1\|WP_014091938.1\|513311_513695_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_014091933.1\|508588_508948_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131113
NZ_CP007172.1\|WP_014091932.1\|507889_508570_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_CP007172.1\|WP_014091940.1\|514601_516041_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_014091960.1\|528596_530012_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP007172.1\|WP_025279756.1\|520428_522858_+\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|212103
NZ_CP007172.1\|WP_014091935.1\|509783_511595_+\|LapB-repeat-containing-protein	unknown	unknown	gnl\|CDD\|380190
NZ_CP007172.1\|WP_014091934.1\|508954_509413_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP007172.1\|WP_014091953.1\|519576_520413_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP007172.1\|WP_025279757.1\|523715_525149_+\|glycoside-hydrolase-family-125-protein	unknown	unknown	gnl\|CDD\|377716
NZ_CP007172.1\|WP_014091939.1\|513795_514605_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223550

Protein	Function_ID	Function_description	E-value
NZ_CP007172.1\|WP_025279758.1\|525247_526120_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	2.704e-58
NZ_CP007172.1\|WP_025279755.1\|517360_518605_+\|extracellular-solute-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.17611e-40
NZ_CP007172.1\|WP_014091937.1\|512151_512964_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	8.03215e-47
NZ_CP007172.1\|WP_014091955.1\|522871_523738_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.42772e-70
NZ_CP007172.1\|WP_014091952.1\|518683_519574_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.99846e-67
NZ_CP007172.1\|WP_014091958.1\|526241_527990_+\|mannose-6-phosphate-isomerase	gnl\|CDD\|380413	cd07010, cupin_PMI_type_I_N_bac, Phosphomannose isomerase in bacteria and archaea, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in many bacteria (e.g. Bacillus subtilis) and archaea. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily does not contain an alpha helical domain that exists in eukaryotic and some prokaryotic PMIs. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death.	8.54885e-54
NZ_CP007172.1\|WP_014091936.1\|511685_512117_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	8.50199e-27
NZ_CP007172.1\|WP_014091960.1\|528596_530012_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.32843e-82
NZ_CP007172.1\|WP_014091939.1\|513795_514605_+\|hypothetical-protein	gnl\|CDD\|223550	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism].	0.00941667
NZ_CP007172.1\|WP_014091931.1\|507231_507819_+\|hypothetical-protein	gnl\|CDD\|239632	cd03577, NTR_TIMP_like, NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. This group contains domains similar to the TIMP NTR domain, which binds MMPs. Members of this group may or may not function as MMP inhibitors.	0.00090237
NZ_CP007172.1\|WP_014091933.1\|508588_508948_-\|hypothetical-protein	gnl\|CDD\|131113	TIGR02058, lin0512_fam, conserved hypothetical protein. This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N-terminus. [Hypothetical proteins, Conserved].	1.27104e-62
NZ_CP007172.1\|WP_014091932.1\|507889_508570_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	1.59831e-55
NZ_CP007172.1\|WP_014091934.1\|508954_509413_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	6.60145e-13
NZ_CP007172.1\|WP_025279756.1\|520428_522858_+\|glycosyl-hydrolase	gnl\|CDD\|212103	cd10791, GH38N_AMII_like_1, N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38). The subfamily of mainly uncharacterized eukaryotic proteins shows sequence homology with class II alpha-mannosidases (AlphaAMIIs). AlphaAMIIs possess a-1,3, a-1,6, and a-1,2 hydrolytic activity, and catalyze the degradation of N-linked oligosaccharides. The N-terminal catalytic domain of alphaMII adopts a structure consisting of parallel 7-stranded beta/alpha barrel. This subfamily belongs to the GH38 family of retaining glycosyl hydrolases, which employ a two-step mechanism involving the formation of a covalent glycosyl enzyme complex; two carboxylic acids positioned within the active site act in concert: one as a catalytic nucleophile and the other as a general acid/base catalyst.	2.97188e-87
NZ_CP007172.1\|WP_014091959.1\|528074_528452_-\|DUF1304-domain-containing-protein	gnl\|CDD\|226282	COG3759, COG3759, Predicted membrane protein [Function unknown].	2.07373e-40
NZ_CP007172.1\|WP_014091935.1\|509783_511595_+\|LapB-repeat-containing-protein	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	1.36422e-122
NZ_CP007172.1\|WP_025279757.1\|523715_525149_+\|glycoside-hydrolase-family-125-protein	gnl\|CDD\|377716	pfam06824, Glyco_hydro_125, Metal-independent alpha-mannosidase (GH125). This family, which contains bacterial and fungal glycoside hydrolases, is also known as GH125. They function as metal-independent alpha-mannosidases, with specificity for alpha-1,6-linked non-reducing terminal mannose residues. Structurally this family is part of the 6 hairpin glycosidase superfamily.	0
NZ_CP007172.1\|WP_014091953.1\|519576_520413_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.03773e-61

>NZ_CP007172.1|WP_014091940.1|514601_516041_+|hypothetical-protein
MSLAKITNTFINVKNLSIFSIASLYGILALQGSFNQYNMNFAERSVSLLSDPYLFIYFILPIWIMLVSKEILTRKDYQNTIRLKTKQRYNLWLLRKCMLISFSLITVLLISSICISVGGDVKLTWSSHIANYQETGLIVSVLNDLISSPISAILVQLLVYFIFLSTIAYFIITITYKIHTPIFIYCVSLLILIYMMYTFTFAMEPLYMNISSLAFAYRVLGQLSQEIIVYTVILVTCILLNTNKVLRKINDLYMYQKKHIIFLAVILVSYVFLGINGADLSINDYIISTNYGSSNEGYTINSILFYAIIYLGIPYLILLGINEKQQLIYYELIRQKTMNKWIFKNILAALQYSCLYLMVTFLIMIGTSYKNYQELLSIDGEILYQYFINGSLQIFFYSLIILLTYSITGKITYALYLNLGLIILLLPVININHILPIGLNAMGMLEDRTPYQLSLQLLIAILMITMILILVNRKRTIPQ
>NZ_CP007172.1|WP_014091939.1|513795_514605_+|hypothetical-protein
MQSMIKKELKEYITITNILIIIIGSLAPTLYILSQANNQTYLHWLGLYSNSVGSFQALLFPLFIVILTIPKLSTKLSNKFISYVRIRKNIYQYLGATMISNAIIVFVGSFLLVFIPFIITYYIVPIFGLIGYQPESMGLNTVAAINNDIATNDALSFLINVSPLFYAIVYAAWVGFNGILWYIVSWCLLIIKNNIFLALSIPFVVYQIAHFLFSLLGVPQFGSLISIFPFNFEKVPVWNMLLFPMLLIVGVISMLIYIYKNIEKMDSLS
>NZ_CP007172.1|WP_014091938.1|513311_513695_+|hypothetical-protein
MKKKLLIISGVLIMVLFASVSYVQAGSTYANYSTTVGKFNGNGYTAYQTKKVAGQKANVKSTKTGGYKLNVRTNSAGSNGTWSADFTNSKNIDLSNGHNKGTKTRLHFSNKITTTRDVQASGSWRSN
>NZ_CP007172.1|WP_014091937.1|512151_512964_-|histidine-phosphatase-family-protein
MKKNILKAMVMFCALLLIAGCGNDSTTSKADTTEKKDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVTSAGKGLKDVDFGAAYSSDSGRAIQTANLILEESAKSSDTKLQTDARFREFNFGSYEGDLNHNMWTDIAKSQGKTLEEWQSAGISPKIFADSVAKLDKTRVKEGENWPAEDYATIQARLKNGITEVAKKESKKGDENVLLVSHGLSIGALLDTIEPGYKLPATGIKNASVTKITYKDGKFKIEDVNDMSYAEKGQE
>NZ_CP007172.1|WP_014091936.1|511685_512117_+|universal-stress-protein
MDKYNRILVAIDGSEPAKLAFEKGLELALKLDGVLGIASIVDIRAFSPNVSYDGSLEEKAELELKGNVNEYAEEARAKGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NZ_CP007172.1|WP_014091935.1|509783_511595_+|LapB-repeat-containing-protein
MKRLFKLLLTLACVVSLTYPTLTAFAEENSSGNSVVNIPDTALKTYLNSQLKQASDADITADQMALIKSVTITGTNYTDLTGLEAAVNLNTLNISNTNITTLNPIRTLTTLNYLNVSGDVITDSFFPDLNQLTNLENISISSKNVTHNVFTKFNKLPKLRFLYAQNSMLITDISGLASLENLETLFLQFDGIDDFRPLNDFASFKNGKLKSLAAYGQNMGRTNPRITLKSGKLNYNATDQTLYLPFSMMPNQLTSFDGTVAPFSKSTSASNTYVGFNDVAVASSRLSITDDGITISGVTKEEFDGLTELEYNARFDFPTGSYPTPPSMTSYTISAGTYDQYFDISHTLDLTADESIGYNQYTLATEGQFLKAIHAETDDGTAVQSNFDQVVDFNTPGEYTVTLNAENSAGLKADPLEVKVTIYAKPIIKADSSISYEQKTTKTAEEFLTETHSSVTENAALTSDFNDVVDLNTPGEYTVTLNAENERGQKADPVQIIVTVTAKADPEQPVPPTKEKPTTEKPADNKSVATKEPTKATEKNKKSEESPSNLTTKENTEPTTKEVTKTTEQKLPKTGDAGLGTWPVAFTSIMMGLMAIILLKKRK
>NZ_CP007172.1|WP_014091934.1|508954_509413_-|winged-helix-turn-helix-transcriptional-regulator
MNNEQSMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERQLLTIEQGTRDKRQRCIFLTTAGKELENELGAAQRKQMAQIFAESTDTNGIHFTDVMTGYAKNRPGAALIKDFKE
>NZ_CP007172.1|WP_014091933.1|508588_508948_-|hypothetical-protein
MEKLLFIQTGFGVDVHGQDITKAAERAVRNAIFTNSMPGIRSQLPDNRLENMVVNIKLALPCDADELDEEVIRAIIPYGTVTIETMPGGMLTTSGIFLEDKADKNDLMYIVNASVETGY
>NZ_CP007172.1|WP_014091932.1|507889_508570_+|type-1-glutamine-amidotransferase
MIIDVLQHVSHEGPGLITKWAKENQHQLRIHCLFSESNHVPTNSEFLIVLGGPMGVNDTAEFPWLKEERNLIKRLINQEKPVFGVCLGAQQIATALESNISINDEKEVGWFPVNRTSTKLPFFPEKLDVFHWHQETFSLPNGATRLFSSEGCVNQGFLYGEKIIGLQFHFEMEKAGIETILQIDEEFITPGKFVQSVAEMRERDVPEDNKQMLEAILDYLVAEKNI
>NZ_CP007172.1|WP_014091931.1|507231_507819_+|hypothetical-protein
MKKALCPILLLLILLASCSTQDETLSPNTKIHKNSVIRADYKIPQNLAELESDSEDIVQVKLIRNKEIGKGNNSSITEVEIIKNYKGSFEPGDKVDISEPWLLTSGEYQAVENYIALEKGQEYILFLSGGHGTDKVSSITSLGYGKYNKSLQEQKADMNDFNTVGEVQKYDFISGLEAEIIKYQEIKKEMLKTYN
>NZ_CP007172.1|WP_025279755.1|517360_518605_+|extracellular-solute-binding-protein
MKKIVSISCIVAVLMLLASCGSGESSSSKVEFYTDKGGENVGILNSMSEQIEKDGGVGYKTVGYTEVTSYETTVQQSLDSEKAPGLFTWWSGDKLKKLVDNDLVVDLTKEWKEYYEKEGVNPGLADAFTIDGKVYAAPFSVLYNGILYNKHLFDKYDLEVPTTWDEFIKVCDTLKANKIEPIGLKNDPWASFLWFQTLIASYAPDLYVGLTNGDIKYTDPEMKKVMKIWQKMITKGYFGDPVDPASQIKMFSTDKSAMVYEPTVTSATLKKEYNMEPGKDFDVFVAPSMTADQKQVIFFEASPIVVSKESKQSAEAQKVLRSFYKKDVQQIFVDEAGIINTDNTKSSDPVNGSFVKEAADANKYQVMVRYYEATPSEVVTVATDELWKFFYKPTDTVLDDTLNTIQKVADSAFK
>NZ_CP007172.1|WP_014091952.1|518683_519574_+|sugar-ABC-transporter-permease
MSLQAKANLKRGRGLKPYLYIAPAVLFVFCFCILSIIFTLVISFTDWSGLGSFNFVGFDNYVAVFQDKNFLLSCINTLVWVAAGLIIPVVLPLLFAIAIIKSSFATIFKNLFYFPNAVSGVIVGLIMTSLLSMYGLPQLLGMLGFENLDKNWLNIPYVNTGVMIVAGIWQGIGLNMLLFIIGLVNMPTEPIEAAKLEGASGLALYTKIILPLLKPTIIVVVLMSLVNSFKTFDSIWIMTGGGPYRTSETLAVTMYKESFSNNHLGMGSAIAVMLSVIILVISIFYLRKTFNKEGSN
>NZ_CP007172.1|WP_014091953.1|519576_520413_+|carbohydrate-ABC-transporter-permease
MIQQKHAGIGKWTVNIILIILAVIWIFPFLYVIVNAVKSSAEYSTGNFWDLPKSFSIAENWEYLTQQIQLGSGFINSLIYGTLGGGLGIIMAALAAYAIETLKIKHGLLWFFVIYSGTIFPFQVYLIPIFKAYNKVGLYDTQLGMVLIYAALIIPFSVFVLRNFLMGISKEMLESARMDGASDFYIFRKIYMPMARAPLAAVFLFQFTWIWSDLLFGMTLTKSESARPVMAAVSLLGGSTIQKVPPILLAAIIVSIPTIILFILSHRNLEKGFVVTTK
>NZ_CP007172.1|WP_025279756.1|520428_522858_+|glycosyl-hydrolase
MTLSKKWKLYVLHHSHTDIGYTERQEKLKRYHVDFIQQAIDILMEIEDGKRPEWEGFRWVCENYWQVENFLKNSSEENIACFERYVQAGLIDISLNYLNMTELVDDEVLNHKLAQGRSYADHLAVPLDSAMSADINGYSWGYADALANNGIENLFSCIHTHHGMYPHGKKHHGFWWEGPSGERVLTWVSDHYHMGNELCLVPEHGITYLLEDRFNPKAEVADFEVAEERIFNYIEKLDNDVEYDYYFVPIMVSGMSTDNGAPNGRILERVKTWNELHGDQIEIEMITLNHFFDILRDEMNELPVYRGDWNDWWADGVGSTPAVVKHYKDAQRKYHIGKQLAPDFVAADKQYLDDVEYELALYAEHTWGYSSSVTEPWETLVNDLDFRKSSYAIRANQLASLKLDEILAVKGEVTIRPDRDKLFKVINPQATARTDSVCLYIEHWEDVEGSAVDILLQNIEVVDELTGEVLPSQVREIARAKEVEVVLELTALEEKILRIRLKKELQKEPYRYLAVDKINDIMYDGWQEGLRVNAHQVETKYYSMTFDETNGIVAMIDKRDGNSLLRDSLEHPPFVGIYERTATEPNAWEVRHTMGRNRKKINTDRHVSKLRNIQVCESGEVSATVVFTYDLEGTQMYEIHMKVYRDTPKIDITLRLHKDSIWDPENLYISFPFTTGETEELYFDKMGCLVRPGIDQLPGTNQEFYLVQEGAVYVGAEKSVILALKDTPLLVLGELEHHLIELSGQRGAEKNKEPLYVWAMNNFWETNFKVDLAGFYEFRYTLATLQTTRADVAIDACKSYNQGFLSMYV
>NZ_CP007172.1|WP_014091955.1|522871_523738_+|ROK-family-protein
MYRIGIDIGATNMRVALFDSDNQLIAREQVKTEAKLGPVQALGKLVSMVRLVDPERLAIGIGIGAPGPLDVTNGTVLDAPNLPGWHGFPIRDELERLVNVPVFLMNDAKAAALAEAKIGSGVGYDSVQYITVSTGIGGGFICRGELFPGSHGHASELGNMIVDVSSPNSTLENTCSGSALLRQSKQLFGENQTAAELFVQYEANQEEARQVIEQWLHHFSAAVTSIIQVIDPEVFVLGGAVILRHPWLVEKLHPMVTKRVYSTMREDVQLKVASLGDDAGLYGASMFV
>NZ_CP007172.1|WP_025279757.1|523715_525149_+|glycoside-hydrolase-family-125-protein
MEHPCLFSEGNGGILENNTSLDKEMMGEDTYFRLRRITDEILKEAASDNTELATLIDGTIDRILQQVDLSEKLQRMFRKCMLNTITTTLVQKKDDSAFLFTGDIPAMWLRDSGGQLRVFLNLDDASGKLYDVIGAVIRQQFRYIRLDPYTNAFNFGGNGNCWSEIDQSERSNPWSWERKYELDSLCFPVELAYFYWKQTARVDLFDEGFLAAIKELIRVFRVEQHHEACSEYFFIRNNGIEQDSLPNQGRGTKVGYTGMIWSGFRPSDDACEYGYLLPANMFAVVILGYLEEMVVAFYPKEMELLTAITTMKKEVQEGIDKFGIIDHPKYGKIYAYEVDGLGNSNIMDDTGVPSLLSLPYIKYCDADEAIYQNTRRFSLSKDNRYYFEGTAAKGLGSPHTPPEYVWHMGLAIQGLTSIDDAECQELLRLFETTDAGTELTHEGFLADDPTVYTREWFSWSNSIFCEFILKEIGKWKL
>NZ_CP007172.1|WP_025279758.1|525247_526120_+|MurR/RpiR-family-transcriptional-regulator
MKSGIVRLQALAKQSMGSYQDIAKYIVTNAETVKTMHITQLADECFTSPATIVRMCKKLGYKGYTDFKQDLVLNLHKWFFEKQEVYNRGYIYPNKAAIEIGEVITNLTINGMIKSVQFLDSELVTDLAKILYEAERMDFYGCGISNLVAQDFSYRFLRSGKSTSAFADSHIQISQAQQSDASCVAVGISYGGETQEVITALEIAKQLGAYTISFTSEEDNSLAQVADCNITVAQIEHPEGYVAAASRIEMLHVMDIIYSVYISKYDETVAAKISRTRPYFKKKSGDQEQE
>NZ_CP007172.1|WP_014091958.1|526241_527990_+|mannose-6-phosphate-isomerase
MGNNQTRYNHSPTTKVKGDFKTWTGFQAIFSELSHAIAKSSKKKAILVIETYPGVQIETLRCALEKYFEAATILCADDFAMRGQEIQEKFAMLITEDRVFGRMAAIKMEDYYEKAKLELLRKKVATSDDLTIVFGTGASLVADAEVTVYMDVARWEIQQRMRSGEIGNWNDTNLDEDILRKYKRGFFLDWRAADRLKVELFDKINYYVDANELDHPKMVQWSDYCSGLEQMLQGPFRFVPYFDPGVWGGQWMKENLGLDTSVNNFAWAFDGVAEENSLYLQFGTVRIETPAINAVLKYPMELLGELVYSRFGAELPIRFDFLDTIGGQNLSLQVHPNKEYIKKQFGMDYTQEESYYLLDTKDDAVVYLGVKDDVNSEELIGALEDAQSGEVALDAPRYINTFPAKKHDHFLIPSGTVHCSGADSMILEISLCAYIFTFKLWDWGRLGLDGKPRPVHIEHGKKVINWNRSEKWVAENLVNQFVPLIETKTHTKERTGLYKTEQIYTERDWFSDFIDYDNMEKTVNMLNLVEGDKIVVESLEGKFDDFEVHYVETFVIPAQIERFRIRNIGENERVAILRARIM
>NZ_CP007172.1|WP_014091959.1|528074_528452_-|DUF1304-domain-containing-protein
MTILAFMLTFIVMIEHIYIMILEMFFSNTKLAAKTFGVEKELLANKKVQTLFANQGLYNGFLAAGLAWGLFFAGNVYTGTVQIFFLSCVVIAALFGGATSSKGILVKQGLPAVLALVAVLLVVTI
>NZ_CP007172.1|WP_014091960.1|528596_530012_+|multidrug-efflux-MFS-transporter
MQQERTMERKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAAISPTFAILMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGLKYMQNVSVVTKPKIDVLSIILSTLGFGGVVFAFSSAGEHGWGSATVLTAIIVGGISLALFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVIALFFLTRIETDTTALTIIILHSVLMIGISMVMMPAQTNGLNQLPRKLYPDGTAIMNTLQQVSGAIGTAVAITIMTAGQKAYMETAQGAGPEEMVASLTAGIQNAFVFGLIMACIGLVCSLFIRKAK

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Crispr_ID: NZ_CP007172_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP007172_3

786770-787170

Orphan

Consensus_repeat	Method
ACAACCAGCTAACGAATTTAGAT	CRISPRCasFinder

6 spacers

The CRISPR arrays of NZ_CP007172_3

>merge|NZ_CP007172|3|786770-787170|CRISPRCasFinder
ACAATCAGCTAACCAATTTAGATGTCAGCAAAAATATAGCATTATATTTACTTTATTTGGATAATAATCAGCTAACAGATTTAGATGTCAGCAAAAATCTGAATTTAGGAGGGATCTATTGTCGTAACAACCAACTAACGAATCTAGATGTGAGCAAAAATCCAAAGTTATCCACCCTTCAGTGTGAAGATAATCAACTAACGAGTTTAGACCTCAGTAAAAATCCAAAGTTAATGTGGCTTGAATGTGAAAATAATCAGTTAGCAAATCTTGATGTGAGTAATAATCCAGAGGTATTGAATATTTATTGTTATAACAACCAGCTAACGAATTTAGATCTCAGTAGTAATGTGAATTTACAGACTTTTTTTTGTTCTGACAACCAGCTAACGAATTTGGAT

>NZ_CP007172|3|3|786770-787170|CRISPRCasFinder
ACAATCAGCTAACCAATTTAGAT	GTCAGCAAAAATATAGCATTATATTTACTTTATTTGGATA
ATAATCAGCTAACAGATTTAGAT	GTCAGCAAAAATCTGAATTTAGGAGGGATCTATTGTCGTA
ACAACCAACTAACGAATCTAGAT	GTGAGCAAAAATCCAAAGTTATCCACCCTTCAGTGTGAAG
ATAATCAACTAACGAGTTTAGAC	CTCAGTAAAAATCCAAAGTTAATGTGGCTTGAATGTGAAA
ATAATCAGTTAGCAAATCTTGAT	GTGAGTAATAATCCAGAGGTATTGAATATTTATTGTTATA
ACAACCAGCTAACGAATTTAGAT	CTCAGTAGTAATGTGAATTTACAGACTTTTTTTTGTTCTG
ACAACCAGCTAACGAATTTGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007172.1\|WP_014092204.1\|793846_794836_+\|lipoate--protein-ligase	unknown	unknown	gnl\|CDD\|161920
NZ_CP007172.1\|WP_014092207.1\|796509_797499_-\|acryloyl-CoA-reductase	unknown	unknown	gnl\|CDD\|176249
NZ_CP007172.1\|WP_014092201.1\|790689_791310_+\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NZ_CP007172.1\|WP_014092193.1\|779717_780329_+\|SnoaL-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379275
NZ_CP007172.1\|WP_014092203.1\|792969_793842_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP007172.1\|WP_014092192.1\|778951_779632_+\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NZ_CP007172.1\|WP_077913075.1\|783088_783751_+\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273919
NZ_CP007172.1\|WP_014092205.1\|795038_795791_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_014092200.1\|790072_790681_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223477
NZ_CP007172.1\|WP_014092191.1\|777990_778830_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP007172.1\|WP_014092190.1\|777302_777860_+\|DNA-topology-modulation-protein-FlaR	unknown	unknown	gnl\|CDD\|181235
NZ_CP007172.1\|WP_014092194.1\|780448_781231_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP007172.1\|WP_025279798.1\|788220_789108_+\|glyoxalase	unknown	unknown	gnl\|CDD\|319934
NZ_CP007172.1\|WP_014092189.1\|776639_777140_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_014092202.1\|791636_792893_+\|GTPase-HflX	unknown	unknown	gnl\|CDD\|225171
NZ_CP007172.1\|WP_014092199.1\|789107_790073_+\|ring-cleaving-dioxygenase	unknown	unknown	gnl\|CDD\|319935
NZ_CP007172.1\|WP_014092206.1\|795812_796463_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP007172.1\|WP_049793584.1\|782333_783140_+\|PTS-transporter-subunit-EIIB	unknown	unknown	gnl\|CDD\|273919
NZ_CP007172.1\|WP_014092196.1\|784955_785960_+\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|238645
NZ_CP007172.1\|WP_032363853.1\|783917_784121_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376324

Protein	Function_ID	Function_description	E-value
NZ_CP007172.1\|WP_014092204.1\|793846_794836_+\|lipoate--protein-ligase	gnl\|CDD\|161920	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase. One member of this group of proteins is bovine lipoyltransferase, which transfers the lipoyl group from lipoyl-AMP to the specific Lys of lipoate-dependent enzymes. However, it does not first activate lipoic acid with ATP to create lipoyl-AMP and pyrophosphate. Another member of this group, lipoate-protein ligase A from E. coli, catalyzes both the activation and the transfer of lipoate. Homology between the two is full-length, except for the bovine mitochondrial targeting signal, but is strongest toward the N-terminus. [Protein fate, Protein modification and repair].	8.07223e-109
NZ_CP007172.1\|WP_014092207.1\|796509_797499_-\|acryloyl-CoA-reductase	gnl\|CDD\|176249	cd08289, MDR_yhfp_like, Yhfp putative quinone oxidoreductases. yhfp putative quinone oxidoreductases (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
NZ_CP007172.1\|WP_014092201.1\|790689_791310_+\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	2.08714e-32
NZ_CP007172.1\|WP_014092193.1\|779717_780329_+\|SnoaL-like-domain-containing-protein	gnl\|CDD\|379275	pfam13577, SnoaL_4, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	7.84916e-06
NZ_CP007172.1\|WP_014092203.1\|792969_793842_+\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.04131e-68
NZ_CP007172.1\|WP_014092192.1\|778951_779632_+\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.89412e-20
NZ_CP007172.1\|WP_077913075.1\|783088_783751_+\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273919	TIGR01995, beta-glucosides_PTS_EIIBCA, PTS system, beta-glucoside-specific IIABC component. This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.	1.4503e-53
NZ_CP007172.1\|WP_014092200.1\|790072_790681_+\|alpha/beta-hydrolase	gnl\|CDD\|223477	COG0400, COG0400, Predicted esterase [General function prediction only].	1.26042e-67
NZ_CP007172.1\|WP_014092191.1\|777990_778830_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	3.92446e-21
NZ_CP007172.1\|WP_014092190.1\|777302_777860_+\|DNA-topology-modulation-protein-FlaR	gnl\|CDD\|181235	PRK08118, PRK08118, DNA topology modulation protein.	3.58708e-41
NZ_CP007172.1\|WP_014092194.1\|780448_781231_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	8.58101e-48
NZ_CP007172.1\|WP_025279798.1\|788220_789108_+\|glyoxalase	gnl\|CDD\|319934	cd08346, PcpA_N_like, N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins. The N-terminal domain of Sphingobium chlorophenolicum (formerly Sphingomonas chlorophenolica) 2,6-dichloro-p-hydroquinone1,2-dioxygenase (PcpA), and similar proteins. PcpA is a key enzyme in the pentachlorophenol (PCP) degradation pathway, catalyzing the conversion of 2,6-dichloro-p-hydroquinone to 2-chloromaleylacetate. This domain belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	1.58214e-40
NZ_CP007172.1\|WP_014092202.1\|791636_792893_+\|GTPase-HflX	gnl\|CDD\|225171	COG2262, HflX, GTPases [General function prediction only].	1.25376e-170
NZ_CP007172.1\|WP_014092199.1\|789107_790073_+\|ring-cleaving-dioxygenase	gnl\|CDD\|319935	cd08347, PcpA_C_like, C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins. The C-terminal domain of Sphingobium chlorophenolicum (formerly Sphingomonas chlorophenolica) 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins. PcpA is a key enzyme in the pentachlorophenol (PCP) degradation pathway, catalyzing the conversion of 2,6-dichloro-p-hydroquinone to 2-chloromaleylacetate. This domain belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	3.99543e-73
NZ_CP007172.1\|WP_014092206.1\|795812_796463_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.35878e-30
NZ_CP007172.1\|WP_049793584.1\|782333_783140_+\|PTS-transporter-subunit-EIIB	gnl\|CDD\|273919	TIGR01995, beta-glucosides_PTS_EIIBCA, PTS system, beta-glucoside-specific IIABC component. This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.	8.32315e-62
NZ_CP007172.1\|WP_014092196.1\|784955_785960_+\|adenosine-deaminase	gnl\|CDD\|238645	cd01320, ADA, Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.	3.03911e-101
NZ_CP007172.1\|WP_032363853.1\|783917_784121_+\|hypothetical-protein	gnl\|CDD\|376324	pfam00358, PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1.	9.1015e-26

>NZ_CP007172.1|WP_014092196.1|784955_785960_+|adenosine-deaminase
MNEQHIKVIPKVELHCHLDGSIRIETLRKVYEIQGNPLGFSDERLQQMTVAAAHCTLTKYIDCFRLVSSGLHTKEALQLALLDVVEQASLENIIYMEIRLSPLHLRTVTFSMEEVAEALINACQIAEKHYSIKIGLIFCCMRRQLEKSNLAVINLAKKYLGMGVVAIDLAGDEGRYPTKDYQSLFTYASRIGVPYTIHAGETGNLSSVLTALEFGASRIGHGIALAQSQQAMEKAVKQEVLLEMCPVCNIQTGAAQNWQSYPVDTFIRNKLPICFNTDNRTVSNTTLTNEFLQVNQHCFALSEELLLKQAKTALAHSFTDDTTKQVLKKQLIMT
>NZ_CP007172.1|WP_032363853.1|783917_784121_+|hypothetical-protein
MGVGFAVRPTTGTLFSPIAGTVESIFPTNHAITLKSVPGIDVLVHIGLETVELGGAGILLEVKKGDR
>NZ_CP007172.1|WP_077913075.1|783088_783751_+|PTS-transporter-subunit-EIIC
MQKIIPKSLHFTFVPFLTLIIGVPATILVFGPLANIASSIISSAILGLFGFSPIVTALFVGILYTPLVILGLHWPLVAIGINNLATAGTDYLLPMIFTAPLAQMAVVFAVYLKTKNPDVKKICVPAMVSDFFCIIEPSIYGVTLPVKRRFVYTCIGTAVGALIIAVAGVHNFASTIGVLGIGGFINPQTGDVSYVIVVALASLATMLIAFLLAFFTFKEA
>NZ_CP007172.1|WP_049793584.1|782333_783140_+|PTS-transporter-subunit-EIIB
MGKYDKLNAFIIENVGGDSNITALTHCVTRLRFTLKDESLVNRDALINHEEIMTAQAANGQYQVVVGMQVGDIYQEMLPKLSISNHKEETGTNDSSNKDKKTLLNRFIDTITKIITPTLGVMIGCSLILGVQSLLVATKVVSPGDGAFVILNAVGYALFTFFPVILGYTSAKTFNSDPFIGMIVGAALVFPNLLTDLVDSEAIYQLFSGTIFQTNIYSDFLGIPIIFPANGYTSTVIPIIFSMFFYQNGNILSKKLFLNHCISPLFHF
>NZ_CP007172.1|WP_014092194.1|780448_781231_+|DeoR/GlpR-transcriptional-regulator
MGKVESRRNKIIEILNENSILSLANLAESLNVTTETIRNDLKSEQLAGKVVQAHGSVAIAHTTIARDVPYSFRKEVNSKSKSKIADQACKLVSPGQVIAIEHNSISVMLIHMLGQYPQLLNNITIITNSFSIMHYVQEKKLELPIIFLGGTFSLNQENAFGSMTVHQMKELKADISFISPGAIDEDLEITAYKEQDADLQKAIMKNSQKNILLIENSKYPSIAMWKVNHATDYDTIITEVDFTKEQLETLAKAQIDILNI
>NZ_CP007172.1|WP_014092193.1|779717_780329_+|SnoaL-like-domain-containing-protein
MLLTRNLPYTEETMRAKADILELVQFERFCRDNALWDAMETCFMKDSSVKISWYQGTGHGFIEASKKMTNPAPHKIYNTQIWINGDRAVAIMQATIQTRSIINGVEMELNSDAKLVTRVERIDGSWYIKAFEGVYEKDSLTPVVPSENANVPAELLANFRKSYACLALSLTLNGYEIDNSLPGIDRPEQVAEFFKEADEWLIQ
>NZ_CP007172.1|WP_014092192.1|778951_779632_+|Crp/Fnr-family-transcriptional-regulator
MDIRTELQKSQLCEDFTDNQLTELMTQITVREKHYKNNEILFYTKEATKIFILVNGNVAIAKNTISGKRILGKSVSERGEITGEIYYFSHRNPFWDYAIALEPTTVLEISGIEKEKLQQLDLTLQNRLLVNLLKSVTRKFEYIGEKVRITSEDSVRAKISNYLLGLQQEDGSIELTETREEIADYLDITRPSLSRELGRMQKENIIQIEGNKVIILDVVIFDAFIE
>NZ_CP007172.1|WP_014092191.1|777990_778830_+|alpha/beta-fold-hydrolase
MSILKLEGANLSYQKVGQGPVLIFIPGANGTGDIFLPLAAELQEHFTVVTVDRRAYGKSGVTEALPERASLAHDDYRVKRDAADIAALAKEVSDEPVYILGSSSGSIVAMHVLRDYPAVVKKIAFHEPPINTFLPDAKKWQDSNEEIVQTAINKNMAEAMQLFGKTLHIAPIDAVSMSKPAVSTEDAIEEDPVTKQMKYWFQYEIRQYTSSDISVADFEPYIEKITLLNGTDSKGSFPQDVNKYLSEQTGLEIVDIPGGHLGYIQKPAGFAEVLLEMWS
>NZ_CP007172.1|WP_014092190.1|777302_777860_+|DNA-topology-modulation-protein-FlaR
MNQFNDLQSKLKNKQRILVIGPNGAGKSTFSSKLGKYLSMEVYHLDKIFWKKDWEHLSELEFKLKIAEILNSEQPYIIDGDYLSSLKDRLAYADLVIWIKIPVSICLINIMKRRFKYLFAKRPDMAEGCDEKLKLSFLMYAAKYNKRSGIPTKELLENDYKGETYIIESYRVYKEYCKALGIVAG
>NZ_CP007172.1|WP_014092189.1|776639_777140_+|hypothetical-protein
MKKPVKISLIIVGIAVVIFAGVMLSYRFLKSMDVTETAEVNKSATGSHVLLATQGSKFKDSVIDQVKEEMEGKNVHISIIDTTKLDKVKADDYDKVVLFTTVQSDDIPENVTTFMNDNKDKNIHIAVTADSGNWDDQPNDVDAISEASKSENKQDFVDDLTHAILK
>NZ_CP007172.1|WP_025279798.1|788220_789108_+|glyoxalase
MIQGIHHVSALTKSFTENHHFYAEVLGLRLVKNTVNQDNIKMRHLFYGDYAGTPGTLLTFFEIPKIGSSYQESTYFGNITLGIPKDTTNYWEKRLNDYAVPFKKAAKTLSLHDPDQMGIILTEITETISHPTIHTDIPSAQQIVRILGADYHVPSPTETSPFFTNYFGLDSQNGVLVDSNQMSFTRLYKTGSEKKSRTGRGTIDHIAYTVKTKEAVDKLHEIALQNKLKIEEFVDREYFKSLYIKEPSGLRIEFASAEPGFTLDEPLETLGEKLALPSFLEEKRTEIETYFGGKE
>NZ_CP007172.1|WP_014092199.1|789107_790073_+|ring-cleaving-dioxygenase
MMKDLKGIHHVTAMTSSAEKNYAFFTEVLGMRLVKKTVNQDDIHTYHLFFADDKGSAGTDMTFFDFPNLPKGRHGTDSISRVSFRVPTDGALEYWQDRFNQLEVPHGEIQTLFGQKYLTFQDFDDQQLQLVSDEKDSGVAPGTPWKNGPVPEKYAIYGLGPVFLTVVSLTNMDAILQSILGFRKVTEENGLHLYEVGEGGNGAQVVVEERTDIPAAMQGYGGVHHVAFRVEDHDELQKWIERMNTIEAPNSGYVNRFYFESLYVPVSERILFEFATDGPGFASDEPYETLGEKLALPPFLEPKRAEIEKMVRPINTKRTEK
>NZ_CP007172.1|WP_014092200.1|790072_790681_+|alpha/beta-hydrolase
MEHLFIPGKNKELAPLLLLHGTGGDEKSLVEVAEFIASDAPVLSLRGEIKEGGANRFFKRFHDGSLDLVDLESKTKDLIATTRELAEKYQLDFEKIIAVGYSNGANIAANALLQAENSFHKAILFHAMPAGNGQPAFSIDHRSVFLSAGLNDPLITAKASEQLVEILEKRGAKVETVWTAAGHSLTMEELEEAKKWYHKNEK
>NZ_CP007172.1|WP_014092201.1|790689_791310_+|flavin-reductase-family-protein
MTSFKSADLTQKENYKFLTGSIIPRPIAFVTTLAEDGVTVNAAPFSFFNIVSSDPAIISIAVQRVEGEQKDTARNAAFTKELNIHIVSEEMVEEINKTAARLAPDVSEVADTNFHLANVPGMKTPKIAEAAIVLTAKLDRLVLVTNDAGKVVTDLLLARVLTYEFNDNVFDKEKEYILPEALAPVARLAGNDYSKLGEVFRLIRPN
>NZ_CP007172.1|WP_014092202.1|791636_792893_+|GTPase-HflX
MEKKVLIVGVSQKQKDFDYSMEELANLAAANNMEVVGELRQNIDRENRATYVGKGKVDEVKGLAEMQDASLVIFNDELSPSQIRNLEEALELDVMDRTGLILAIFANRAKTKEAQLQVEIAKLQYELPRIFGQGEDMDQQSGKGGLSNRGSGEKKIETDRRTIKHQIRHLQKELAMLVDDREVRRRKRKKNEIPVVSLVGYTNAGKSTTMNGLVRAYSETADKQVFEKDMLFATLETSVREIVLPDNKQFLLTDTVGFVSKLPHQLVKAFRSTLEEARDADLLIHVVDYSDPHYKTMMQTTEETLKAVGVEDVPVIYAYNKADLLEDEIYPKQTENTIVFSAREQPSLEFLTEVIKKELFSGYEKSEFLIPFEAGQVVAYLNDHAKVLETEYLENGTKMVAEVSPVDLQKLKAYQVEQ
>NZ_CP007172.1|WP_014092203.1|792969_793842_+|metallophosphoesterase
MKKTGWGILGAVVAFTGYAYWSTKHLTLTNYEIVSDKIPKEWNEARFVQLSDLHSASFGLYNNPLLSMVNEIAPDAVFLTGDILDGDESPVVAMALVRKLAKKFPTFYVSGNHEGRSAFYEDFKADIEAHQVTVLENERYFLKKDGAAIMVAGVQDPRFFKEDWVESELSKSEWEEEALTASLDEATSNLSADYFTILLAHRPEFWSLYQAYPVDLVLSGHAHGGQFRLPLTEGLFAPGQGFLPKWTAGIHRAAGKALIVSRGLGNVTKIPRLFNDPEVIQITLKAKGES
>NZ_CP007172.1|WP_014092204.1|793846_794836_+|lipoate--protein-ligase
MIYLDNEDVLDQAYNFAMEEYALRFLDENETYFMFYRMKPTIIVGKNQNTLEEINQTFVEQHDVDVLRRLSGGGAVYNDEGNLSFSMITKDDGNSFQNFARFTEPVIHALQNLGMNAKLSGRNDIEIDGKKISGNAQFATKGRLYSHGTLLFDVDLSMLESALKVDPEKYLSKGVKSVRSRVTTIREHLTKDMDIQTFKQVLLESIFKTTDIPRYKFTETDKMGIEKLRIERYRNWDWTYGKSPKASMKRKKRFPAGTIEFQLELNKGQIKEAIIYGDFFGTEDVTELADRMIGCRYDRESIRKILQSIDAKDYFGHIEKEAIVDMLFE
>NZ_CP007172.1|WP_014092205.1|795038_795791_+|hypothetical-protein
MAIKKLNDFYFKKLGNWNLIHSFMKGFWRTFFLLVLLLIVGDIVVIELMDSRFFIPAILLSLLCIPLFYYILIYTRAKKFIRVRYQLRNFSELTMMRRYLLFAYLEKSGFSTRDDLEKLLRFIHSEMAEEKKNDKPLNSVVGVFVATFLAILGGSFLFLVDNVVERLIAAVLIIVFAIILYAAGTFMMRVVRSKSEINKRKEHELTKEIIAIQTAMLVSENTSYHPFLAMEKKVSENDFLKEIITSRSFL
>NZ_CP007172.1|WP_014092206.1|795812_796463_+|GntR-family-transcriptional-regulator
MTTKRKETRESVCYREIKKKIRNGELKPGDRLIENTLSKQLDISRTPIRKAIGMLAADGYVEYNDFRGAFVKDSIINKERYFEMTEILGLFLKQAIHKIRTKKISFNKLKATSKLAEIKCQEEQSDPAVYFDYEKWFVQDLLTYLKNNYYLKISEDFFSNIKEFGDEEVIKIAQNASVKTIDNIQNFIDALDVHDYDRCLKIIDDMIDAHVLVAYR
>NZ_CP007172.1|WP_014092207.1|796509_797499_-|acryloyl-CoA-reductase
MKSFQALFIEKESETTSLQFREISLDTLPENEVTIEVHYSGINYKDGLAVLPDGKIVSEYPFVPGIDASGIVVETKTKRFQVGDEVIVTSYDFGVSYFGGYSEYIRVPAEWVVPLPAGLSLKEAMILGTAGFTAALSVDALEFSGVTPDAGKIAVSGGTGGVGSLSSAILSKRNYQVVASSSKADAKEFLQKFGVSEVVSREAFQPEKIRALDKQLFAGAIDCVGGKPLAYLLTAVQYGGAVTTCGMSAGGKLDTTVFPFILRGIQLFGIDSVLCPMPKRERIWRRLATDFQLANLEELATEIPFSELPNALHQVMNGGITGRYLVKIK

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Crispr_ID: NZ_CP007172_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP007172_4

2761864-2762043

Orphan

Consensus_repeat	Method
TATTATTACTAAGGTCTA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP007172_4

>merge|NZ_CP007172|4|2761864-2762043|PILER-CR
TATTATTCCTAAGGTCTAACCTCGTTAAATCTGCACTGGCACTAACATCTATACTAGTAAGATAATTATCAGCAAAATCAAGTGTCCTTAAGTCCGGATTATTACTAAGGTCTAGGTGACCAGTCAAGCTACCGTATTCTCCAAAAAAAGTAACTAGCTTAGTATTTTTACTAAGGTCTA

>NZ_CP007172|4|3|2761864-2762043|PILER-CR
TATTATTCCTAAGGTCTA	ACCTCGTTAAATCTGCACTGGCACTAACATCTATACTAGTAAGATAATTATCAGCAAAATCAAGTGTCCTTAAGTCCG
GATTATTACTAAGGTCTA	GGTGACCAGTCAAGCTACCGTATTCTCCAAAAAAAGTAACTAGCTTAG
TATTTTTACTAAGGTCTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007172.1\|WP_014093844.1\|2766220_2766661_-\|ribose-5-phosphate-isomerase-B	unknown	unknown	gnl\|CDD\|376799
NZ_CP007172.1\|WP_014093833.1\|2748286_2749036_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_003753951.1\|2751185_2752373_-\|elongation-factor-Tu	unknown	unknown	gnl\|CDD\|234596
NZ_CP007172.1\|WP_003749772.1\|2770310_2770592_-\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NZ_CP007172.1\|WP_003753956.1\|2754635_2755106_-\|30S-ribosomal-protein-S7	unknown	unknown	gnl\|CDD\|235398
NZ_CP007172.1\|WP_014093842.1\|2762847_2763492_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|238244
NZ_CP007172.1\|WP_014093846.1\|2767888_2768941_-\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_CP007172.1\|WP_014093839.1\|2758648_2759128_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP007172.1\|WP_014093847.1\|2768977_2770249_-\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CP007172.1\|WP_095075147.1\|2759175_2760747_+\|leucine-rich-repeat-protein	unknown	unknown	gnl\|CDD\|372554
NZ_CP007172.1\|WP_025280113.1\|2763488_2765504_-\|transketolase	unknown	unknown	gnl\|CDD\|223100
NZ_CP007172.1\|WP_014093843.1\|2765537_2766212_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NZ_CP007172.1\|WP_014093845.1\|2766855_2767887_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176219
NZ_CP007172.1\|WP_014093848.1\|2770648_2771113_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
NZ_CP007172.1\|WP_014093838.1\|2757236_2758634_-\|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl\|CDD\|234897
NZ_CP007172.1\|WP_003720973.1\|2755136_2755550_-\|30S-ribosomal-protein-S12	unknown	unknown	gnl\|CDD\|235355
NZ_CP007172.1\|WP_014093837.1\|2752482_2754570_-\|elongation-factor-G	unknown	unknown	gnl\|CDD\|234569
NZ_CP007172.1\|WP_014093849.1\|2771146_2773216_-\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP007172.1\|WP_014093836.1\|2750584_2750992_-\|DUF2712-domain-containing-protein	unknown	unknown	gnl\|CDD\|371299
NZ_CP007172.1\|WP_014093835.1\|2749733_2750519_-\|membrane-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP007172.1\|WP_014093844.1\|2766220_2766661_-\|ribose-5-phosphate-isomerase-B	gnl\|CDD\|376799	pfam02502, LacAB_rpiB, Ribose/Galactose Isomerase. This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).	1.54989e-77
NZ_CP007172.1\|WP_003753951.1\|2751185_2752373_-\|elongation-factor-Tu	gnl\|CDD\|234596	PRK00049, PRK00049, elongation factor Tu; Reviewed.	0
NZ_CP007172.1\|WP_003753956.1\|2754635_2755106_-\|30S-ribosomal-protein-S7	gnl\|CDD\|235398	PRK05302, PRK05302, 30S ribosomal protein S7; Validated.	2.46604e-105
NZ_CP007172.1\|WP_014093842.1\|2762847_2763492_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|238244	cd00429, RPE, Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose phosphate pathway. In the Calvin cycle Ru5P is phosphorylated by phosphoribulose kinase to ribulose-1,5-bisphosphate, which in turn is used by RubisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase) to incorporate CO2 as the central step in carbohydrate synthesis.	5.40743e-114
NZ_CP007172.1\|WP_014093846.1\|2767888_2768941_-\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	2.63141e-179
NZ_CP007172.1\|WP_014093839.1\|2758648_2759128_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.58876e-10
NZ_CP007172.1\|WP_014093847.1\|2768977_2770249_-\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	0
NZ_CP007172.1\|WP_095075147.1\|2759175_2760747_+\|leucine-rich-repeat-protein	gnl\|CDD\|372554	pfam13306, LRR_5, Leucine rich repeats (6 copies). This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.	5.13143e-25
NZ_CP007172.1\|WP_025280113.1\|2763488_2765504_-\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NZ_CP007172.1\|WP_014093836.1\|2750584_2750992_-\|DUF2712-domain-containing-protein	gnl\|CDD\|371299	pfam10916, DUF2712, Protein of unknown function (DUF2712). This family of proteins with unknown function appear to be restricted to Bacillales.	0.00251634
NZ_CP007172.1\|WP_014093845.1\|2766855_2767887_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176219	cd08258, Zn_ADH4, Alcohol dehydrogenases of the MDR family. This group shares the zinc coordination sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of an beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	4.44593e-172
NZ_CP007172.1\|WP_014093848.1\|2770648_2771113_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	3.26718e-36
NZ_CP007172.1\|WP_014093838.1\|2757236_2758634_-\|deoxyguanosinetriphosphate-triphosphohydrolase	gnl\|CDD\|234897	PRK01096, PRK01096, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NZ_CP007172.1\|WP_003749772.1\|2770310_2770592_-\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	5.75607e-36
NZ_CP007172.1\|WP_014093837.1\|2752482_2754570_-\|elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
NZ_CP007172.1\|WP_014093849.1\|2771146_2773216_-\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	2.63899e-86
NZ_CP007172.1\|WP_014093843.1\|2765537_2766212_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	3.2019e-93
NZ_CP007172.1\|WP_003720973.1\|2755136_2755550_-\|30S-ribosomal-protein-S12	gnl\|CDD\|235355	PRK05163, rpsL, 30S ribosomal protein S12; Validated.	8.80596e-88

>NZ_CP007172.1|WP_095075147.1|2759175_2760747_+|leucine-rich-repeat-protein
MYQTKKALTLVLSFQKFRNLSRGKNDRNLKLGGVIQLIKKIVWASFSLVLVLFSFPVVSTAATSGDFEYTVNGNEATITDYTGTITDVTIPATIGANNEYTVTSIGNGAFYSKGLTAVTIPDSVKTIGDGAFTINSLQQLVLPNSVQSIGINSFSVNQLETISLSTSLENIPRFAFLANKLKSVEIPANVTSIDASAFENNYITDITIQNPNIQLAYQAFAAQTILSKLIVPSDNTLPLKNYIHFNDASSQLTMDNLTVTDLADGVTYDSTKNALVFTAEPLESTFSLYTGTNRYDSYYDISEYGPSGKPIILFEYTKPVIATYKDETGTELASSTRIDGSIGDAYTSTPKTIDGFTLKETTGNPTGQFTNTTQNISYIYEKDPIQNGTVTVTYQDESGNSLVQDTTLTGEVGSTYQTESKNITGYQLTKVDGNESGTFSSNQTIVTYVYEKITSDENNSNGPGETTNNNSTNAEDADSPSTTTQMKASNSTLPKTSDSSDNFLFAVGGLLTALAMGILFFRR
>NZ_CP007172.1|WP_014093839.1|2758648_2759128_-|GNAT-family-N-acetyltransferase
MSKLTFRNATEFDSALILHYILELAKHEGIGQDVVATEAGLRDTLFNQKVAEVIIAEYEDQSVGFALFFHNYSTLLGKKGLYLEDLYIIPEMRGKGFGTQFFKYLSKLALSRDCGRFEWWCLNENKSGMDFYNKIGAEKMAEWTVHRLSKIEMEKLSNL
>NZ_CP007172.1|WP_014093838.1|2757236_2758634_-|deoxyguanosinetriphosphate-triphosphohydrolase
MKWDKLLNDKRRRESGVTRSKNTDVRSAFENDFQRIVMSASFRRLQDKTQVFPLEKSDFVRTRLTHSMEVSTIAKSMGNMVTHTIQEEKLDEDFTKDHADKIPEILACAGLLHDMGNPPFGHFGEESIREWFRDNLATITYKNKSLAEILTPQMKEDFYYFEGNAQVLRVVSKLHYLFDQYGLNLTFATINAVIKYPVSSLKINKNQIKSKKLGYFYADESLFNEITTATEALDNRHPLTYLLEVADDIAYLNADLEDGVKKGIVNITQILRGFEEIEEHNKVTAACYNELKKKSERYEGQEESFIVQQWLASNVRGQLINRSLEVFYANYEAIMAGTFNDSLIDASEAEQLVQILQSLSFTYIYQDKGIVESEIAGNEIISKLLETFIPAVIYYDSETPERQTAKDKRLLTLISDNYLGCYRKNAEGESETMKLYLRLLLVTDFICGMTDSYAKDLYQRLNGLS
>NZ_CP007172.1|WP_003720973.1|2755136_2755550_-|30S-ribosomal-protein-S12
MPTINQLVRKPRQSKIKKSTSPALNKGLNSFKRELTDVNSPQKRGVCTRVGTMTPKKPNSALRKYARVRLSNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTAGVENRGQSRSKYGTKKPKK
>NZ_CP007172.1|WP_003753956.1|2754635_2755106_-|30S-ribosomal-protein-S7
MPRKGPVTKRDVLPDPIYNSKLVTRLINKMMVDGKRGKSQAILYSAFDIIAQETGKDPMEVFEQAMKNIMPLLEVKARRVGGANYQVPIEVRADRRSTLGLRWLVNYARLRGEKTMEVRVAREIMDAANNTGASVKKREDTHKMADANRAFAHYRW
>NZ_CP007172.1|WP_014093837.1|2752482_2754570_-|elongation-factor-G
MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATTYGVPRVVFVNKMDKIGADFLYSVGTLHERLAANAHPIQLPIGAEDTFEGIIDLIEMNALYYEDDLGNDPHIKEIPADLKELADEYRGKLVEAVAELDEELMMKYLEGEEITKEELKAGIRKGTLNVEFYPVVCGTAFKNKGVQPMLDAVLDYLPAPTDVPAINGVLPDGEEAARHADDSEPFSSLAFKVMTDPYVGRLTFFRVYSGTLNSGSYVQNSTKGKRERVGRILQMHANHREEISIVYAGDIAAAVGLKDTTTGDTLCDEKDQIILESMEFPEPVIQVAIEPKSKADQDKMGQALAKLAEEDPTFRAETDQETGQTLISGMGELHLDILVDRMRREFRVEANVGDPQVSYRETFRKSAQVEGKFVRQSGGRGQYGHVWIEFGPNEEGKGFEFENAIVGGVVPREYIPAVQAGLEGALDNGVLAGYPLIDIKAKLYDGSYHDVDSNEMAFKVAASMALRNAAKKCDPVILEPMMAVEVVIPEEYLGDIMGNITSRRGRVDGMEARGNAQVVRAFVPLANMFGYATHLRSGTQGRGVYTMQFDHYEEVPKSIAEEIIKANGGNNKED
>NZ_CP007172.1|WP_003753951.1|2751185_2752373_-|elongation-factor-Tu
MAKEKFDRSKPHVNIGTIGHVDHGKTTLTAAITTVLAKKGFADAQAYDQIDGAPEERERGITISTAHVEYQTDTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPYIVVFMNKCDMVDDEELLELVEMEIRDLLTEYEFPGDDIPVIKGSALKALQGEADWEAKIDELMEAVDSYIPTPERDTDKPFMMPVEDVFSITGRGTVATGRVERGQVKVGDEVEVIGIEEESKKVVVTGVEMFRKLLDYAEAGDNIGALLRGVAREDIQRGQVLAKPGSITPHTNFKAETYVLTKEEGGRHTPFFNNYRPQFYFRTTDVTGIVTLPEGTEMVMPGDNIELAVELIAPIAIEDGTKFSIREGGRTVGAGVVSNISK
>NZ_CP007172.1|WP_014093836.1|2750584_2750992_-|DUF2712-domain-containing-protein
MKKKLVVLGLAGAMFLSGMGILNVSAANYSDTKFSFTLGRLGGNDYTSARQKQNTTASYVKLNSIGKGTMDAWILKSNGASVRSREVTVSQGKSKKIANYAYEDYGKCNVKLAAETSKLQIVRVSATGLWSPDSI
>NZ_CP007172.1|WP_014093835.1|2749733_2750519_-|membrane-protein
MNQFLKIEFKRVFKNKSFLLALALGMFIVIIQQITVARYYSPTEENVFIYLTGYNTTGLGTNLYYLLLPCLVALAGADLLGEDRRTGLDIFSRIRGTDKQYYFSKSIVAFVAGGVAFCLPLIVELFLLMLVYPSVPFDYFASEVPVTYEEMFGNVFYNSPITYEVIFLVIGFVYSGLFALLGILVSFFSSSKYVVLLSPLAIYYGIWIVFSLGGYPEVSPFGFLTPKQAYPLNFQVIWIEFLLLFVVAIIGIAWSVKNEKS
>NZ_CP007172.1|WP_014093833.1|2748286_2749036_-|hypothetical-protein
MWLFFKREILWFLQVNQLKIVGLSLLLILTVIVDVLNTKNGSGTIADAFLGFLQQENRTDNPIASNLNWIIIQSLPVFLFGSYFYTELFMLEEFVTIRFNNRKLAYFSKILLIITVMLVYYLTFFGLVILVSFLYGITFNLQPVLLYEGLNLSLFQIGFCFFVGGIVLISMQLLLSVIIKPFFAIIVALVMIIINCFVTNYWIIGSTSNIAKFVDVNNWFVISIQLIYLLLATIIGVIIYQKTDLYKLN
>NZ_CP007172.1|WP_014093842.1|2762847_2763492_-|ribulose-phosphate-3-epimerase
MTFVAPSLLAADYMNMANSIKEAELAGADYLHIDVMDGHFVPNLTFGIDMVAQIAKTATIPLDVHLMLANPENYIEKFANAGAHIISVHIEATPHIHRVIQQIKQAGCKAGVVLNPGTPANALDSILGDVDLVLQMTVNPGFGGQSFIPTTVENLRYLDNWRRNHRANYVIEVDGGINEASAERCKQAGVDILVAGSYFFRSQEKTACIQILKS
>NZ_CP007172.1|WP_025280113.1|2763488_2765504_-|transketolase
MKKTLDRQAVDTIRSLSIDMIEKANSGHPGMPMGAAPMAYMLFAKHLVFNPANPEWFNRDRFVLSAGHGSALLYSMLHLFGYDVKMEDLKAFRQLDSLTPGHPEFGWTAGVDATSGPLGQGIGMAAGMALAESHLAAQYNQPNYPIVDHYTYAICGDGDLMEGVASETASLAGHLGLGKLIVLYDSNDICLDGDLSATFSENAADRFRAYGWQVLRVEDGNNLAAIQEKIVQAKLETSKPTLIEVKTVIGYGAPTKSGSSASHGAPLGEKEARGAKEHYDWTEEPFTVPTEVRDYLRNYKARGEKLEGAWNTMLTNYKKEFPELASQLDRVLAGEVAADWNTNLPTFEAGASAPTRSASGKMINAIAAELPELFGGSADLGCSNKTFIDASPAYSIADPAGKNIWFGVREFAMGAMLNGMALHSGLRVFGATFFVFSDYVRPAMRMAALMQLPVTYVFTHDSIAVGEDGPTHEPIEHLASLRAMPGLTVIRPADAKETRAAWELAATNTDGPIALVLSRQDLPVLENDQAEVDAGVEKGAYVVAPASNVKPDAIIIATGSEVSLAIEAKHELAKRELDVSVVSLSSWERFEKTSDDYKESILPKEVTARFAIEAGTTFGWKEFIGAEGDMLGIDHFGASAPAKDLFNAYGFTPENVADRVESVIAKAGVRV
>NZ_CP007172.1|WP_014093843.1|2765537_2766212_-|ribulose-phosphate-3-epimerase
MRKIAASIMCADQLHLGDELKRLESAGVELLHCDVMDGVYVNNLALGPEYLEIVRNNTEIPLDIHLATITPLKYIDMFGPVKPEYISFHAEVADDVTEVIRKIRSYNVKPSIAINPETPIEAIYPYLNDVEMVLMMTVNPGFAGQKFQTNVLQKLRDLKAKLAGKVHVPLIEVDGNINKETVGLMRDCLPDIYVLGTSALFHDRDKTSYSERLVHIWSDVEKHV
>NZ_CP007172.1|WP_014093844.1|2766220_2766661_-|ribose-5-phosphate-isomerase-B
MKLTIGCDHGGRRLKDAIVKHLREKNIEVVDIGTYTDDSVDFPSYAEEVANQVVSGQSELGILCCGTGIGMSIAANKVDGIRAAVVSDTFSARATREHNNSNVLCLGERVIGEGLALLIVDTWLEATFAGDRHKRRLDKITELERK
>NZ_CP007172.1|WP_014093845.1|2766855_2767887_-|zinc-binding-dehydrogenase
MKAVVKTNPGYDQMELKDVEEPQAYGDKVKIKVAFTGICGSDIHTFKGEYKNPTTPVTLGHEFSGVVVEVGPDVTSIKVGDRVTSETTFETCEECIYCKERDYNLCSNRRGIGTQANGSFAEFVLSREESCHVLDERISLEAAALTEPLACCVHSALEKTTIRPDDTVLVFGPGPIGLLLAQVVKAQGATVIMAGITKDSDRLLLARELGIDRIVDTLKEDLAEVVFGMTDGYGAERVFDCSGAVPAVNQGLPLTKKKGDFVQVGLFAEKKNAIDEESIIQREIAYIGSRSQKPSSWILALDLLANGKINTDKMITKVYGLDDWREAFEAVMAGNEIKVLVKS
>NZ_CP007172.1|WP_014093846.1|2767888_2768941_-|galactitol-1-phosphate-5-dehydrogenase
MRAAVLYENNVIKAEQIDEAICGKDEVRVEVKAVGICGSDIHKMQTRWKYPLPAVMGHEFAGVITEVGSEVENRAIGDRVAGIPLEPCMECNYCKAGDFSLCDNYRMVGSHFHGGFAENVVMKADNVISIGDLDFEEGAMIEPLAVSMHGVLGIEPRLGDTAIVFGIGTIGILVVQCLLLAGVKDIIAVDISDKKLADAKEFGCRYTINPKNEDLKERTLAYTNGLGADIALECAGSKITQEQCLLVTKKKGKVGFLGIAYADVLLHEEAFENIFRRELTLKGFWNSYSAPFPGEEWRTSIEFVKQGRIKLKPLISHRYKLEETKEAFEMILSREHDYNKVMILPQKGDD
>NZ_CP007172.1|WP_014093847.1|2768977_2770249_-|PTS-galactitol-transporter-subunit-IIC
MDTLLAGVQYVLNLGPTVILPIMIFFIALIFRVPAKKALRSAITIGIGFVGINLVISLLSSNLGPAAQQMVERFGLNLTIIDAGWPAAAAASWASPVAAILIPICLAVNLALIFFKVTKTLDIDIWNYWHFIAAGATGYIVTGGNWWFAILCAIIYEVAVLWMADRTQPMVEEFYGLKGISLPTGSTAAFGFIGIPVGWLIAKIPGIKNIHVDPETIQKRFGIFGEPMMMGLILGIAIGLLAGYDVGAVAQLGMSMGAVMFLMPRMVKILMEGLIPISESAREFMKSRFKGRELYIGLDAALSIGHPANISTGLILVPITLFLAVIIPGNKVLPFGDLATIPFYVSFVVASRKGNILHSVLAGTVVIALALLMATDFGLVHTEMMKGVYEFPKGATQVSTLDMGGNFFNWVILKFSQAWAAIF
>NZ_CP007172.1|WP_003749772.1|2770310_2770592_-|PTS-sugar-transporter-subunit-IIB
MGQFKILVACGAGIATSTVVTDRVERLVKEHNVDAEVKQIKISEAASMQDGADLIVSTTILPTTYKIPAIIATSYITGMGMEELDEEILAHLK
>NZ_CP007172.1|WP_014093848.1|2770648_2771113_-|PTS-sugar-transporter-subunit-IIA
MDLVQFLKKGMVWVQSDIDKQEDLFQMVAESGKSEGYVTDDFLTRLTDREQTFPTGLKLDGYGVALPHTDPECVTEQFIAVITVKDGIPFKLMEDAGQTVEANLIFVLGLNEPHSQLAVLQQLMGTIQDKDNVTALLRAKDEAEVKQILETITV
>NZ_CP007172.1|WP_014093849.1|2771146_2773216_-|BglG-family-transcription-antiterminator
MYLDERSNSLLKELLRHPDTSSINLQAKFGLTRRQVDYSFQKINNWLEEQTYPKIHRAANGRFIVEPDLFQIIGEEDGEKTDWYIPSEKERASLIILMLTTGSEELSLNHFISELEVSKNTVLRDLKLVQKTLDKFNLEVKYSRMRGYLIDGDEWNQRTALIYAAEHIIESFGGEEYLQDFMQVEEARIKELREKLEQVEHHLNLHFIDNKMQILPYILEAVFRRMKKGQTITTSFLIDYNELSDTREYGAAEILIEEEPNMPEAERMYITLQLLTSNVLPKQYLKSEETHKLRLALEQVLSEFEKKACIQLVDKESLLEKLFAHIKPAYYRIKYHLTTDYSILDKIDQEFQAVHYIVKESLVPLERFIGSKVPENESIFITLFIGGHLIESTEKLQTRLKAVVVCPNGLSISRLMEKTLRSLFPEIFFYQAMSIREFEQTKVGYDIVFSAVPLSTDKKFFLINQLMDGKERLELRRRVMRSVYLVDEVNISVDQLMKTISKFADIKDAARLEKVLADYLMPVPEETTSTSSTKSSLADLLEGTRITRKKSVENWHEAIHHAASPLLSAGVVEERYVAEMKRQYPAPIMNIILRNTIAIPHAETEKGVKSLGMSLLYLEEGLPVEGGKNLHFIVVIAAVDKNAHFTALLQLMELSENKKVLKKLADAGNTEEMHQIIKNFTDLETKKTM

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Crispr_ID: NZ_CP007172_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP007172_5

2844079-2844191

Orphan

Consensus_repeat	Method
AACGCGAGGATTTAATCCTTCGTGGAAGTTTCAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP007172_5

>merge|NZ_CP007172|5|2844079-2844191|CRISPRCasFinder
AACGCGAGGATTTAATCCTTCGTGGAAGTTTCAAAACGTTCTTTGTTTTGATTTACTTCTTCAATATAGATCCGAGTAACGCGAGGATTTAATCCTTCGTGGAAGTTTCAAAA

>NZ_CP007172|5|4|2844079-2844191|CRISPRCasFinder
AACGCGAGGATTTAATCCTTCGTGGAAGTTTCAAAA	CGTTCTTTGTTTTGATTTACTTCTTCAATATAGATCCGAGT
AACGCGAGGATTTAATCCTTCGTGGAAGTTTCAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007172.1\|WP_003754047.1\|2841888_2842206_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NZ_CP007172.1\|WP_014093915.1\|2845294_2846659_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NZ_CP007172.1\|WP_014093913.1\|2844733_2844937_-\|DUF3188-domain-containing-protein	unknown	unknown	gnl\|CDD\|371501
NZ_CP007172.1\|WP_014093910.1\|2841183_2841780_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP007172.1\|WP_003754045.1\|2840926_2841169_-\|YaaL-family-protein	unknown	unknown	gnl\|CDD\|378478
NZ_CP007172.1\|WP_032363920.1\|2835992_2838035_-\|alpha-xylosidase	unknown	unknown	gnl\|CDD\|269879
NZ_CP007172.1\|WP_014093912.1\|2844272_2844737_-\|DUF3284-domain-containing-protein	unknown	unknown	gnl\|CDD\|378692
NZ_CP007172.1\|WP_014093922.1\|2851887_2852823_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NZ_CP007172.1\|WP_025280133.1\|2842235_2843969_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NZ_CP007172.1\|WP_014093917.1\|2847419_2847893_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_014093921.1\|2850902_2851844_-\|GW-domain-containing-glycosaminoglycan-binding-protein	unknown	unknown	gnl\|CDD\|226309
NZ_CP007172.1\|WP_014093918.1\|2847928_2848570_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_014093907.1\|2838277_2839630_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NZ_CP007172.1\|WP_014093923.1\|2852965_2854705_-\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|227320
NZ_CP007172.1\|WP_025280135.1\|2849275_2850790_-\|gluconokinase	unknown	unknown	gnl\|CDD\|212659
NZ_CP007172.1\|WP_014093905.1\|2833845_2835255_-\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NZ_CP007172.1\|WP_014093909.1\|2840106_2840826_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP007172.1\|WP_014093906.1\|2835251_2835989_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223635
NZ_CP007172.1\|WP_025280134.1\|2844939_2845161_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007172.1\|WP_014093908.1\|2839655_2839952_-\|transcription-antiterminator	unknown	unknown	gnl\|CDD\|99906

Protein	Function_ID	Function_description	E-value
NZ_CP007172.1\|WP_003754047.1\|2841888_2842206_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	1.23532e-40
NZ_CP007172.1\|WP_014093915.1\|2845294_2846659_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	4.26294e-160
NZ_CP007172.1\|WP_014093913.1\|2844733_2844937_-\|DUF3188-domain-containing-protein	gnl\|CDD\|371501	pfam11384, DUF3188, Protein of unknown function (DUF3188). This bacterial family of proteins has no known function.	1.88527e-10
NZ_CP007172.1\|WP_014093910.1\|2841183_2841780_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	1.8956e-130
NZ_CP007172.1\|WP_003754045.1\|2840926_2841169_-\|YaaL-family-protein	gnl\|CDD\|378478	pfam10704, DUF2508, Protein of unknown function (DUF2508). This family is conserved in Firmicutes. Several members are annotated as being the protein YaaL. The function is not known.	1.87825e-14
NZ_CP007172.1\|WP_032363920.1\|2835992_2838035_-\|alpha-xylosidase	gnl\|CDD\|269879	cd06593, GH31_xylosidase_YicI, alpha-xylosidase YicI-like. YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a homohexamer (a trimer of dimers). All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. The YicI family corresponds to subgroup 4 in the Ernst et al classification of GH31 enzymes.	1.34199e-156
NZ_CP007172.1\|WP_014093912.1\|2844272_2844737_-\|DUF3284-domain-containing-protein	gnl\|CDD\|378692	pfam11687, DUF3284, Domain of unknown function (DUF3284). This family of proteins with unknown function appears to be restricted to Firmicutes.	6.21397e-28
NZ_CP007172.1\|WP_014093922.1\|2851887_2852823_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	3.5553e-05
NZ_CP007172.1\|WP_025280133.1\|2842235_2843969_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_CP007172.1\|WP_014093921.1\|2850902_2851844_-\|GW-domain-containing-glycosaminoglycan-binding-protein	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	1.00275e-93
NZ_CP007172.1\|WP_014093907.1\|2838277_2839630_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	1.52776e-76
NZ_CP007172.1\|WP_014093923.1\|2852965_2854705_-\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|227320	COG4987, CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
NZ_CP007172.1\|WP_025280135.1\|2849275_2850790_-\|gluconokinase	gnl\|CDD\|212659	cd07770, FGGY_GntK, Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of a group of gluconate kinases (GntK, also known as gluconokinase; EC 2.7.1.12) encoded by the gntK gene, which catalyzes the ATP-dependent phosphorylation of D-gluconate and produce 6-phospho-D-gluconate and ADP. The presence of Mg2+ might be required for catalytic activity. The prototypical member of this subfamily is GntK from Lactobacillus acidophilus. Unlike Escherichia coli GntK, which belongs to the superfamily of P-loop containing nucleoside triphosphate hydrolases, members in this subfamily are homologous to glycerol kinase, xylulose kinase, and rhamnulokinase from Escherichia coli. They have been classified as members of the FGGY family of carbohydrate kinases, which contain two large domains separated by a deep cleft that forms the active site. This model spans both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Some uncharacterized homologous sequences are also included in this subfamily. The Lactobacillus gnt operon contains a single gntK gene. The gnt operons of some bacteria, such as Corynebacterium glutamicum, have two gntK genes. For example, the C. glutamicum gnt operon has both a gluconate kinase gntV gene (also known as gntK) and a second hypothetical gntK gene (also known as gntK2). Both gluconate kinases encoded by these genes belong to this family, however the protein encoded by C. glutamicum gntV is not included in this model as it is truncated in the C-terminal domain.	0
NZ_CP007172.1\|WP_014093905.1\|2833845_2835255_-\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	0
NZ_CP007172.1\|WP_014093909.1\|2840106_2840826_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	8.11967e-70
NZ_CP007172.1\|WP_014093906.1\|2835251_2835989_-\|HAD-family-phosphatase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	6.72242e-33
NZ_CP007172.1\|WP_014093908.1\|2839655_2839952_-\|transcription-antiterminator	gnl\|CDD\|99906	cd05564, PTS_IIB_chitobiose_lichenan, PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	1.79037e-26

>NZ_CP007172.1|WP_025280133.1|2842235_2843969_-|DNA-polymerase-III-subunit-gamma/tau
MAYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAKAINCEHGHDGEPCNECDICKGTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKYKVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPHKLPLTIISRVQRFDFKRITTQDIIGRLEFILKEEKTPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVDDALEITGSIAQGLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPNLEETLERALIDDEFVSLAKRANSFKIYEFVKILNTAQQQMRFSNHPGIYVEVALVQLTQAGQTVGESAAPVEVASGDVSALKQQMEQLQLELQTLKKQIASGAGVAPTEKPAQNRGGSKKQINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAASLDTFVLKFKHEIHCQMAMDNPNFVETITSSIAKLTQVNYTFIGIPEDQWAEVRENFLHSHGGNGDSEEGANPEARKPAEDPFVLEATKLVGEDLLEIKD
>NZ_CP007172.1|WP_003754047.1|2841888_2842206_-|YbaB/EbfC-family-nucleoid-associated-protein
MRGMGNMQGMMKQMQKMQKEMAKAQADLEVQEFTGTAGGGMVTVKATGKRVITDVVINEEVVDPEDIEMLQDLVLAATNDVLKQIEDTTSQTMGKFTQGLNLPGM
>NZ_CP007172.1|WP_014093910.1|2841183_2841780_-|recombination-protein-RecR
MHYPEPITKLMDSFMKLPGIGPKSAARLAFYVLDMKEDDVLDFAKALVDAKRNLSFCSVCGHITDKDPCYICADTSRDRSIICVVQESKDVIAMEKMRDFHGLYHVLHGTISPMDGIGPEDINIPDLLKRLQDDTIEEVILATNPNVEGEATAMYISRLLKPSGIKITRIAHGLPVGGDLEYADEVTLSKAMEGRREV
>NZ_CP007172.1|WP_003754045.1|2840926_2841169_-|YaaL-family-protein
MESRSNKFGRKKEKKIGKLHKSYDAYLMELIEVTQENWHKQKVLLRKSFEYDPNLEYEEKKAEARYFYLFKEARKRQLKK
>NZ_CP007172.1|WP_014093909.1|2840106_2840826_-|GntR-family-transcriptional-regulator
MSTKILKYETIAFDLRKKILSGFYKQNDQLPLEKEMCEEYDTSRITVKKAMDQLVLEGLVVKRRGAGTFVKDVENPDADVLQSMQFMGFSEENKHRNVSSDILKFEIINPDESTLNKLRISELDFVYHIIRVRKIDKKPHAIEECFMPINLISGLRMDIVASSIYTYIESVLGFSIQSAHKTVSAMMPTEFEKEYLKIADVSPILNIEQVAYLDNGQPFEYSNTKYRADKYEFHAINIR
>NZ_CP007172.1|WP_014093908.1|2839655_2839952_-|transcription-antiterminator
MKISLFCNAGMSTSLVASKLKKAYLERGITYDVEAFDFSALQEEADETDVIILGPQIAWAFDDVTKDYPDKKVIQLTMAEFGSMDGEKVLERVEKELN
>NZ_CP007172.1|WP_014093907.1|2838277_2839630_-|PTS-sugar-transporter-subunit-IIC
MASEKLNKFQMKLTKIMGKIAGNKLLLSLRDTFIMAAAPLMIAGFAIMISSVFLDPTGIIFGNSGLHLGSLISGSEKAFLVSDFANNLRTLQGYFNLFINGTMAINALLVVAGFAFFGSRRFFPKNKEPIVVTFYALAGFFITLPWTVTTLDTKGKEVTINGIVNSNFIGQQGIFTGLIVSGITIYVFNKLIQKNVTFKMPDTVPPAVAKSFESLVPGVVTLAIFVIVAGVLNGVFDTSLPEALLWLLQKPALAVAATPLFAVVAIVSTPILQWFGIHGTSVWGPIFGLTWNINDNENIMGTAQHLYSTLFMNFTVVSSGALTLAPIIAIIIFSKRADNKKIAKLAIAPGIFNVSEPVTYGLPIVLNPILFIPYLLSWVIPFFLGQLLTEIGLIPIITNNVPWTVPPILSGLLYSGSIMGALYQALVIVIVVILYMPFVRVANNLANKLD
>NZ_CP007172.1|WP_032363920.1|2835992_2838035_-|alpha-xylosidase
MEGAFEMEPFYLTEKAAVRRAPILNAEADKFVITSGKLTINIAKEPFRIEIKNENKVVFSTSIKKISRQYVTPGLGHRINANGYREAFLSWDVANDEKFYGLGEKFSSVEKSATRSTSYAMDACATNTTDLAYKAHPILLSTSGYGLLLTTAKRTHWDVGDFCFVSGTVLVEGPVLRGHIFVGDTLKDLIAEETELQGHSEMIEPWTLGVWYSRCAYMNKEELYGVKDKLGELELPFDVLNIDVHWGKNYWYEKFWVDCCDFEWGEDKFPEPTKMFAELMEQNVACSLWMNPYLPPGTAVYEEAVEKGYLVKTTEGGLAHIKRRQVSEIGIPDLTNPEAYSWWKEKVKDLLRLGIRVLKPDYTDRIPEDALFFNGYTGKDMHNAYIYLYIKACYDATQEIHGTSLVWKRPGFLGTGKFAGTWSGDVESSFEGLKYTIRGGLSVGFTGESYWSSDIAGFKGEKPTPELYIRWSQVGMLCSLARYHGTTEREPWFYGEQAVNIVRDYSELRYSLVPYMLEMATEAEDRGLPMMRHLALEFQNDAFVHAIDDEFLLGEDILVAPILEAGATKRDIYLPAGAWYDRKTGEGYPGRSTITVDVTLEDMPIFIREGAVIPQFKRKLQHLKDFETEAVEICVYGKAKKMQGTLVSENRVRYAYTILADGSISTDYPGEVTLRQVYEA
>NZ_CP007172.1|WP_014093906.1|2835251_2835989_-|HAD-family-phosphatase
MTKKLFVTDLDGTLVTRNNEIELADLHAIRSWQQQGNLWAVATGRKWDSVVELLQRYDLAADALILENGALILASSGEVIWQKNIQTETAKQVTNFDLSLVEEVCLVTSFNQATPQQLLNLASFKETQAISAITLRYATADLAEEYVNQVEALITDAVFRNMNYIDIAPNGCSKGAAVKFLMERFMLTKNEVSVIGDSFNDISMFEVSSHPFTLEHAEKAMHEQGALVVKNVHEAINKVRLEWDF
>NZ_CP007172.1|WP_014093905.1|2833845_2835255_-|glycoside-hydrolase-family-1-protein
MTKQIEFPKGFYWGSAASATQTEGAAHEGGKGENIWDYWYKTQPKRFYEKVGPEKASEFYDNFRSAIKLLSQTGHNSFRPSISWSRMFPNGFGEVNPEAVRFYNEVIDALIEEGVEPIMNLYHFDMPLAMQEIGGFENKEVVEHYVAYATTCFRLFGDRVKRWFTFNEPIVPVEGGYLYDFHYPNKVDPKAAAQVAFNTLLASAKAIEAYHKISDGKIGIVLNLTPSYPRSDNPADMEAARIADIFCNKSFLDPAVLGKFPEGLKEILARHDCLPVYSEEELAIIERNTIDFLGVNYYQPRRVCARDTLPNPDAPFMPEFYFQNYEMPGRRMNVYKNWEIYEQALYDVAINIRDNYGNIEWMVSENGMGVKDERRFAKGDYIEDDYRIEFFEDHLYWLNKGILEGSNCIGYHVWTFIDNWSWMNAYCNRYGLVSLNLATGNRTIKKSGEWFKALHDNNGFSYEGVLPYE
>NZ_CP007172.1|WP_014093912.1|2844272_2844737_-|DUF3284-domain-containing-protein
MNVTQKLYISQKECFDTIVSSAIYDVKNATGKTVQRHKLEGHKYQRTMSNGALATTKIVQVKPYELYQFETSSRVNTHTTTYTIKSTSETTCEVTYNELIETEKTLNKMNNIIVGFMFGFFRKKRVKNLLKSIELSVINESKKKQEKSAAKSEQ
>NZ_CP007172.1|WP_014093913.1|2844733_2844937_-|DUF3188-domain-containing-protein
MKIVNALFIISIGLIIIMFSPAYGKDGMASVPILVTGLVVVLIGCLFIVLKLRKDKKEKNKKESIEK
>NZ_CP007172.1|WP_025280134.1|2844939_2845161_-|hypothetical-protein
MIILNCPMKRDYITELLETHDKDGITFKKISEQGMKLTFETNIEDEEKAAKIAKETIKATEIGSVLYFQVSVG
>NZ_CP007172.1|WP_014093915.1|2845294_2846659_-|PTS-sugar-transporter-subunit-IIC
MNGLTAFLEKYFVPVAAKIGSQKHLVALRDAFISTMPITMAGSIAVLLNAFFRDFPTDWGWTGFVSAMQPLIEVNGYVYNGTLAIVSIIFAFSLGYNLSKVYEVDRLAGGLVSLAAFVMNLTVTVSLDAVKAAIAASNANFDVNTLPKEFAGIYGFFSLSQVNGTGLFTAMIFGFISTIIYAKLMRRNIIIKMPDTVPPAVSKAFAAIIPALVALYVVGIIDWAFFKVTNMDVITWISKTIQEPLLSLSQGYGAVLLVTFLVQLLWFFGIHGPNVLAPVLESLWGTAQLQNISAAQEGVKLPFEWVRGSFDAYVWMGGSGGTLVLIIALLMFSKRADARTVAKLSLAPGIFNINEPIMFGLPIVLNTIYLIPFIIAPMIMVTIAYFATTLGLVGPVKIAVVWVMPPLLNSFLATGGDWMAPVISLINMVVAFLIWVPFVITANRVGVPEEEMKA
>NZ_CP007172.1|WP_014093917.1|2847419_2847893_+|hypothetical-protein
MNQDLRLPQNNKEGLLYGVIICSITAFLMTTFNTYLQIRIVNADFLLTIVKLFPLFFIVAMLLENFIISHFSRKMVTKYMDASDSFNAYILFSVLFTVLGMSFCMTFIGDFIGHGFVIEEGLLSRFFSIWPRNFAIVLFIELIIAQPLARNVMSILH
>NZ_CP007172.1|WP_014093918.1|2847928_2848570_-|hypothetical-protein
MQQLKTKKKWLPALIVAVLVGVLVILAIMFGFFQRQEVFDKYDVAYEIDGKLYEVFPISTTDIGVDKKSDDKHFYFRVNSYYNIDYLFRLAYKQYEINEPSTNKYYSGLIDYSVADNAYVTQKDIYMTKDESYATYDFFDKTGKKIYTYNPEETSTDDYIVRIKPTILQGYKKSDIGSYDDYLDITALFKDKLGMDVKVRIDDDKKMVIFSIK
>NZ_CP007172.1|WP_025280135.1|2849275_2850790_-|gluconokinase
MTSESYIMGVDIGTSSTKAVLFNEQGEVIYREAAHYELVTDETGKAEESPTEIFEAVITSIRRVMNKIDKADLRGISFSSAMYSLILAKSNGELLTECITWADGRSSEALENVKRDNYLFQLYETTGTPIHPMSPFAKICWLKEAEPELFNRAEKFVDIKAYILYRFFDVWVMDESLASGTGLYNISEHDWEFEAIEIVKLTPDFLPKVVPETYQLSGIKTEYAEMMGIPTSVPFIVGGSDGALANIGIQATGQSDVTITVGTSGAVRKLTTEFQVDSRGRTFCYGAGDGYFIAGGAVNNGGKVVEWGLNQFGSESEIKNRDFASFIAHIDEVDPGAAGLLFQPYLLGERAPFWTNDIRGGFVGLTINHTKAHFIRAILEGIAFNLAEVYEAVSAPDDIIYVTGGISAHEGWCKLLADILDREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKQTSPIKATYYPSKNTERYTELRLIFKQVSTQLLSSYSQLNSWQKKFENNS
>NZ_CP007172.1|WP_014093921.1|2850902_2851844_-|GW-domain-containing-glycosaminoglycan-binding-protein
MKKLLSGLIIVVMISLLGNSFTAEAATYDKIIYDKAVNLKGVVNQSKRNDGIRSKMYNVSSDSKLLGYAKKYDKKTLIITREGKTSRGAKWYYVKLGNTNIGWIDALAFKNVGKPTIADTVPALWNSKKAIITTKPKSTSATTYLFQRNSAGNWYEVRDFTSHIGKWGFDPNFSEKSSGTPVGVYRTGLAFGQKGNPGTKLTFKAITNRSYWISNSNDKAYNTWQERSSSSSADEKMKIPQYKYGMEVKYNSKRIKGKGSAVFYHIDSPHYNYTLGCVAQSEANTKEVLKFADKNTLIVLGEESRIKTFSVIN
>NZ_CP007172.1|WP_014093922.1|2851887_2852823_-|LPXTG-cell-wall-anchor-domain-containing-protein
MKKFRGLVFTALFTCLIIPFSLAANAETNETGNNQPNIEEKTTNSTENTVPEVDSKTTEPAKDATTTKTLQTTIDITDSPEVYTYEQNSEISLTDFTKTLSKHTGTELTNYRLADGSELTTKAAGMKEVTLLGDTKDGDTTAVKLNYLVKAPVSTLTVTNLNFDLETKIFSGKTKPFASVYMSSPEDENFGEGRVEADKDGNFYASWATTPKKITAYAFDDTGNFSEEVTYTVPAKKENAAVVKAPADVKKIENNHSVKSVTTTASEASKKVADPESDLPDTGDQGVEWIFVVAGVIVILIAIVLLRKRKK
>NZ_CP007172.1|WP_014093923.1|2852965_2854705_-|thiol-reductant-ABC-exporter-subunit-CydC
MRKSSWIIPYIKENRGLFLLVIFLGTLTFASAGALMFTSGHLISKSSLMPESIMAVYVATVGVRAFGIMRSVSRYVERLMSHSLVLRILEKMRVRLYRLLEPQALLLKSRYKTGDILGLLAGDIEHLQNFYLTTMLPAIVSLVLYAGVVIALGVFSVPFAMLFVFLIGMLVLVLPWVSLLYARGKNAYLKQGRNGLYQKFTDAVFGISDWKFSGREKTFITNYEKDEAAMLHTENKQFHFVNWRDFFSQLVVGFMVIAMVYWSTAESRDGAFSGTMIAAFVLAIMALAEAFVPVSSAISDKSLYQDSLSRLDKVEDPTLPNFDEEMKEMERIDTQEVILKAENLTFAYDEKSPKILNGFDFTLQQGEKVAIIGRSGTGKSTFLKLVQGALLPTDGKLTMNGVEVEKLRPEIPKLTSMLNQKAHLFSTSVLNNIRLGNQGASDEEVYEAAKKVQLHDFIMRMPDGYHTQMSEMGERFSGGERGRIALARILLQNTPIVILDEPTVGLDPITERDLLATIFETLADKSLIWVTHHLVGAEKMDRVLFLEEGKTLMEGPHAELMAAEPRYKRLYQLDRPIEL

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP007172_2	2.3\|516301\|37\|NZ_CP007172\|PILER-CR,CRISPRCasFinder,CRT	516301-516337	37	NZ_CP030151	Bacillus velezensis strain DSYZ plasmid pDSYZ, complete sequence	46249-46285	4	0.892
NZ_CP007172_2	2.3\|516301\|37\|NZ_CP007172\|PILER-CR,CRISPRCasFinder,CRT	516301-516337	37	NZ_CP026611	Bacillus velezensis strain CGMCC 11640 plasmid unnamed, complete sequence	22656-22692	4	0.892
NZ_CP007172_1	1.1\|506896\|35\|NZ_CP007172\|PILER-CR,CRISPRCasFinder,CRT	506896-506930	35	KY971610	Pseudomonas phage PspYZU05, complete genome	103571-103605	11	0.686

1. spacer 2.3|516301|37|NZ_CP007172|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030151 (Bacillus velezensis strain DSYZ plasmid pDSYZ, complete sequence) position: , mismatch: 4, identity: 0.892

agcttcctttttttaagaaattagcaacattttcagc	CRISPR spacer
tactgcctttatttaagaaattagcaacattttcagc	Protospacer
 .** ***** **************************

2. spacer 2.3|516301|37|NZ_CP007172|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026611 (Bacillus velezensis strain CGMCC 11640 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.892

agcttcctttttttaagaaattagcaacattttcagc	CRISPR spacer
tactgcctttatttaagaaattagcaacattttcagc	Protospacer
 .** ***** **************************

3. spacer 1.1|506896|35|NZ_CP007172|PILER-CR,CRISPRCasFinder,CRT matches to KY971610 (Pseudomonas phage PspYZU05, complete genome) position: , mismatch: 11, identity: 0.686

ctgtataaatttcatccgatgaatttcgacatcgt	CRISPR spacer
atgtagaaatttcatcagatgaattttattctatg	Protospacer
 **** ********** *********.. . *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

172887 : 176072

Listeria_phage(50.0%)

holin

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014091672.1\|172887_173340_-	ImmA/IrrE family metallo-endopeptidase	A0A059T7S0	Listeria_phage	4.7e-32	49.3
WP_014091673.1\|173345_173681_-	helix-turn-helix transcriptional regulator	A0A2H4JAR9	uncultured_Caudovirales_phage	3.1e-20	51.5
WP_014091674.1\|173904_174333_+	hypothetical protein	A8ATZ8	Listeria_phage	2.3e-12	45.9
WP_014091675.1\|174344_174764_+	hypothetical protein	A8ASQ1	Listeria_phage	5.5e-19	38.6
WP_014091676.1\|174940_175363_+\|holin	holin family protein	Q2I8E7	Bacillus_phage	5.6e-27	45.6
WP_077905816.1\|175394_176072_+	N-acetylmuramoyl-L-alanine amidase	A0A0N9SGH1	Paenibacillus_phage	1.2e-26	41.5

DBSCAN-SWA_2

1315930 : 1371467

Bacillus_virus(17.65%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014092665.1\|1315930_1317070_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_014092666.1\|1317151_1317547_-	helix-turn-helix transcriptional regulator	A9D9J6	Lactobacillus_prophage	3.0e-14	55.9
WP_014092667.1\|1317697_1317913_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_025279905.1\|1318066_1318600_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_014092669.1\|1318614_1319283_+	hypothetical protein	NA	NA	NA	NA
WP_014092670.1\|1319705_1320644_+	hypothetical protein	NA	NA	NA	NA
WP_014092671.1\|1320759_1322043_+	trigger factor	NA	NA	NA	NA
WP_003719537.1\|1322229_1323489_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.0e-145	63.2
WP_014092672.1\|1323606_1324173_+	type I signal peptidase SipX	NA	NA	NA	NA
WP_014092673.1\|1324207_1324777_+	type I signal peptidase SipY	NA	NA	NA	NA
WP_014092674.1\|1324879_1325422_+	type I signal peptidase SipZ	NA	NA	NA	NA
WP_025279906.1\|1325431_1326295_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_014092675.1\|1326291_1327077_+	ribonuclease HII	G9E3X7	Emiliania_huxleyi_virus	3.8e-29	42.3
WP_014092676.1\|1327210_1328071_+	DNA-protecting protein DprA	NA	NA	NA	NA
WP_014092677.1\|1328340_1330419_+	type I DNA topoisomerase	A0A1V0SB35	Catovirus	6.0e-106	37.2
WP_014092678.1\|1330483_1331788_+\|tRNA	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	NA	NA	NA	NA
WP_014092679.1\|1332073_1332976_+	tyrosine recombinase XerC	A0A2H4PCY2	Mycobacterium_phage	2.0e-13	28.1
WP_014092680.1\|1332996_1333536_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_014092681.1\|1333549_1334959_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A191ZC11	Erwinia_phage	4.9e-43	28.2
WP_014092682.1\|1334979_1335759_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_014092683.1\|1335857_1336277_+	acyl-CoA thioesterase	NA	NA	NA	NA
WP_014092684.1\|1336298_1336619_+	hypothetical protein	NA	NA	NA	NA
WP_014092685.1\|1336611_1337484_+	aldose 1-epimerase family protein	NA	NA	NA	NA
WP_025279907.1\|1337526_1338123_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_025279908.1\|1338280_1338688_+	CoA-binding protein	NA	NA	NA	NA
WP_014092686.1\|1338867_1340835_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	9.6e-122	42.2
WP_014092687.1\|1340831_1343291_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	1.5e-100	32.3
WP_025279909.1\|1343372_1343840_+	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_014092689.1\|1343969_1345829_-	acetyltransferase	B5WZU0	Pseudomonas_phage	2.2e-43	31.9
WP_014092690.1\|1346038_1346746_+	glycerophosphodiester phosphodiesterase	A0A0S2MYI4	Enterococcus_phage	3.2e-11	38.7
WP_025279910.1\|1346967_1348644_+	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_014092692.1\|1348769_1349687_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_003719566.1\|1349801_1350035_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_095075141.1\|1350141_1351386_+	GTPase HflX	NA	NA	NA	NA
WP_014092693.1\|1351357_1352584_+	methionine gamma-lyase family protein	NA	NA	NA	NA
WP_003719570.1\|1352785_1353154_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_014092694.1\|1353224_1354559_+	type I glutamate--ammonia ligase	A0A1V0SJ53	Klosneuvirus	3.5e-06	25.8
WP_025279912.1\|1354752_1356048_+	arsenic transporter	A0A2H4PQU3	Staphylococcus_phage	1.7e-146	62.6
WP_014092696.1\|1356086_1356608_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014092697.1\|1356637_1357252_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	9.3e-15	62.1
WP_014092698.1\|1357406_1357736_+	cell division suppressor protein YneA	NA	NA	NA	NA
WP_014092699.1\|1357833_1358061_+	DUF896 domain-containing protein	NA	NA	NA	NA
WP_014092700.1\|1358207_1360202_+	transketolase	NA	NA	NA	NA
WP_003723442.1\|1360423_1360663_+	YneF family protein	NA	NA	NA	NA
WP_014092701.1\|1360721_1361525_-	DUF2785 domain-containing protein	NA	NA	NA	NA
WP_014092702.1\|1362291_1362798_-	ParB-like nuclease domain-containing protein	A0A220GKT8	Streptococcus_phage	2.1e-52	63.0
WP_025279913.1\|1362807_1364112_-	DUF3440 domain-containing protein	A0A220GKF8	Streptococcus_phage	6.4e-130	50.7
WP_014092704.1\|1364101_1365301_-	DEAD/DEAH box helicase	L0P6E9	Lactobacillus_phage	1.1e-88	46.1
WP_014092705.1\|1365284_1365659_-	hypothetical protein	NA	NA	NA	NA
WP_003723449.1\|1365960_1366689_+	UMP kinase	NA	NA	NA	NA
WP_014092706.1\|1366688_1367246_+	ribosome recycling factor	NA	NA	NA	NA
WP_014092707.1\|1367473_1368232_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	1.1e-22	42.6
WP_014092708.1\|1368245_1369034_+	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_014092709.1\|1369048_1370191_+	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_025279914.1\|1370204_1371467_+\|protease	RIP metalloprotease RseP	NA	NA	NA	NA

DBSCAN-SWA_3

1894107 : 1902418

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014093121.1\|1894107_1894701_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.4e-28	38.6
WP_025279996.1\|1894697_1895747_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.7e-64	44.7
WP_014093123.1\|1895762_1897190_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.1e-53	34.2
WP_014093124.1\|1897174_1899394_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.2e-157	41.1
WP_014093125.1\|1899386_1900070_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_014093126.1\|1900073_1900319_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_014093127.1\|1900330_1901044_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D8KNF0	Synechococcus_phage	2.0e-40	38.3
WP_014093128.1\|1901125_1902418_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	5.5e-17	32.6

DBSCAN-SWA_4

2060022 : 2068011

Faustovirus(14.29%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014093266.1\|2060022_2061108_-	histidinol-phosphate transaminase	A0A1X7BZP2	Faustovirus	5.5e-18	25.7
WP_014093267.1\|2061107_2061482_-	chorismate mutase	NA	NA	NA	NA
WP_014093268.1\|2061478_2062576_-	3-dehydroquinate synthase	E5ERI4	Ostreococcus_lucimarinus_virus	4.4e-23	29.3
WP_014093269.1\|2062578_2063745_-	chorismate synthase	A0A291AU41	Pandoravirus	5.4e-48	39.2
WP_014093270.1\|2063950_2064394_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	6.9e-28	45.8
WP_014093271.1\|2064413_2065379_-	heptaprenyl diphosphate synthase component II	A0A1V0SE37	Indivirus	1.1e-06	20.9
WP_014093272.1\|2065389_2066103_-	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_014093273.1\|2066125_2066893_-	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_014093274.1\|2066951_2067521_-	GTP cyclohydrolase I FolE	E7DN69	Pneumococcus_phage	1.2e-40	47.2
WP_003720260.1\|2067735_2068011_-	HU family DNA-binding protein	A7KV42	Bacillus_phage	2.0e-25	69.7

DBSCAN-SWA_5

2569891 : 2577750

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025280087.1\|2569891_2570863_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	1.2e-51	39.4
WP_014093687.1\|2570870_2571839_-	YvcK family protein	A1IMD5	Streptococcus_phage	9.7e-67	42.7
WP_014093688.1\|2571840_2572716_-	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	4.1e-08	28.8
WP_014093689.1\|2572824_2574555_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	2.0e-171	52.6
WP_014093690.1\|2574600_2575671_-	galactose mutarotase	NA	NA	NA	NA
WP_014093691.1\|2575689_2576673_-	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	2.0e-51	37.2
WP_014093692.1\|2576790_2577750_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	7.5e-88	54.1

DBSCAN-SWA_6

2891396 : 2901611

Tupanvirus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014093960.1\|2891396_2893550_-	DNA topoisomerase III	A0A1X9I6W8	Streptococcus_phage	2.8e-42	33.8
WP_014093961.1\|2893596_2895372_-	DNA helicase RecQ	A0A2K9L3P7	Tupanvirus	1.2e-78	36.9
WP_014093962.1\|2895693_2897160_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	6.7e-96	40.0
WP_014093963.1\|2897442_2897973_-	ADP-ribose-binding protein	A0A0K1L687	Scale_drop_disease_virus	6.3e-28	47.3
WP_025280141.1\|2898030_2899644_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	1.7e-47	28.4
WP_095075148.1\|2899822_2900140_+	hypothetical protein	NA	NA	NA	NA
WP_014093964.1\|2900156_2901611_+	glycoside hydrolase family 1 protein	A0A0B5JD41	Pandoravirus	1.6e-49	29.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP007172

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection