CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP004078	Paenibacillus sabinae T27 chromosome, complete genome	9 crisprs	csa3,c2c10_CAS-V-U3,WYL,cas4,csx1,DEDDh,TnpB_regular.1,cas14j,cas3,DinG,cas14k	0	1	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP004078_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP004078_1

134141-134248

Orphan

Consensus_repeat	Method
GGTCGGGGGTTCGATCCCCTCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP004078_1

>merge|NZ_CP004078|1|134141-134248|CRISPRCasFinder
GGTCGGGGGTTCGATCCCCTCCGCCGCTACCATACATACGGAGGCTTAGCTCAGCTGGGAGAGCATCTGCCTTACAAGCAGAGGGTCGGGGGTTCGATCCCCTCAGCC

>NZ_CP004078|1|1|134141-134248|CRISPRCasFinder
GGTCGGGGGTTCGATCCCCTCCGCC	GCTACCATACATACGGAGGCTTAGCTCAGCTGGGAGAGCATCTGCCTTACAAGCAGAG
GGTCGGGGGTTCGATCCCCTCAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP004078.1\|WP_025332672.1\|140092_140581_+\|acyltransferase	unknown	unknown	gnl\|CDD\|100053
NZ_CP004078.1\|WP_025332657.1\|118607_119462_+\|class-II-fructose-1,6-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|169068
NZ_CP004078.1\|WP_025332661.1\|124197_124395_+\|50S-ribosomal-protein-L31	unknown	unknown	gnl\|CDD\|376487
NZ_CP004078.1\|WP_025332664.1\|127147_127747_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP004078.1\|WP_025332662.1\|124989_126741_+\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NZ_CP004078.1\|WP_025332673.1\|140692_141868_+\|acyltransferase	unknown	unknown	gnl\|CDD\|376607
NZ_CP004078.1\|WP_025332674.1\|142472_143624_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380491
NZ_CP004078.1\|WP_025332675.1\|143620_144439_+\|carbon-phosphorus-lyase	unknown	unknown	gnl\|CDD\|293837
NZ_CP004078.1\|WP_025332660.1\|122787_124065_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|100105
NZ_CP004078.1\|WP_025332659.1\|121410_122766_+\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|236490
NZ_CP004078.1\|WP_025332663.1\|126795_127107_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NZ_CP004078.1\|WP_025332676.1\|144468_145593_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270269
NZ_CP004078.1\|WP_025332671.1\|139442_140096_+\|pyrophosphatase-PpaX	unknown	unknown	gnl\|CDD\|237336
NZ_CP004078.1\|WP_025332669.1\|137450_138389_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NZ_CP004078.1\|WP_025332666.1\|128235_128502_+\|pro-sigmaK-processing-inhibitor-BofA-family-protein	unknown	unknown	gnl\|CDD\|377835
NZ_CP004078.1\|WP_025332668.1\|136085_137207_+\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	unknown	unknown	gnl\|CDD\|236947
NZ_CP004078.1\|WP_025332658.1\|119697_120951_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|183779
NZ_CP004078.1\|WP_025332667.1\|134885_135983_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NZ_CP004078.1\|WP_025332665.1\|127954_128206_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025332670.1\|138401_139439_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527

Protein	Function_ID	Function_description	E-value
NZ_CP004078.1\|WP_025332672.1\|140092_140581_+\|acyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	5.54381e-32
NZ_CP004078.1\|WP_025332657.1\|118607_119462_+\|class-II-fructose-1,6-bisphosphate-aldolase	gnl\|CDD\|169068	PRK07709, PRK07709, fructose-bisphosphate aldolase; Provisional.	1.29217e-166
NZ_CP004078.1\|WP_025332661.1\|124197_124395_+\|50S-ribosomal-protein-L31	gnl\|CDD\|376487	pfam01197, Ribosomal_L31, Ribosomal protein L31.	2.03658e-35
NZ_CP004078.1\|WP_025332664.1\|127147_127747_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	3.59744e-126
NZ_CP004078.1\|WP_025332662.1\|124989_126741_+\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_CP004078.1\|WP_025332673.1\|140692_141868_+\|acyltransferase	gnl\|CDD\|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	1.09365e-18
NZ_CP004078.1\|WP_025332674.1\|142472_143624_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|380491	cd06267, PBP1_LacI_sugar_binding-like, ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. Ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. In most cases, ligands are monosaccharide including lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the domain sugar binding changes the DNA binding activity of the repressor domain.	4.21401e-66
NZ_CP004078.1\|WP_025332675.1\|143620_144439_+\|carbon-phosphorus-lyase	gnl\|CDD\|293837	cd16279, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry. Some members of this subgroup are named as octanoyltransferase (also known as lipoate-protein ligase B).	3.37495e-23
NZ_CP004078.1\|WP_025332660.1\|122787_124065_+\|radical-SAM-protein	gnl\|CDD\|100105	cd01335, Radical_SAM, Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. Mechanistically, they share the transfer of a single electron from the iron-sulfur cluster to SAM, which leads to its reductive cleavage to methionine and a 5'-deoxyadenosyl radical, which, in turn, abstracts a hydrogen from the appropriately positioned carbon atom. Depending on the enzyme, SAM is consumed during this process or it is restored and reused. Radical SAM enzymes catalyze steps in metabolism, DNA repair, the biosynthesis of vitamins and coenzymes, and the biosynthesis of many antibiotics. Examples are biotin synthase (BioB), lipoyl synthase (LipA), pyruvate formate-lyase (PFL), coproporphyrinogen oxidase (HemN), lysine 2,3-aminomutase (LAM), anaerobic ribonucleotide reductase (ARR), and MoaA, an enzyme of the biosynthesis of molybdopterin.	6.17106e-12
NZ_CP004078.1\|WP_025332659.1\|121410_122766_+\|transcription-termination-factor-Rho	gnl\|CDD\|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	0
NZ_CP004078.1\|WP_025332663.1\|126795_127107_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	2.36608e-44
NZ_CP004078.1\|WP_025332676.1\|144468_145593_+\|extracellular-solute-binding-protein	gnl\|CDD\|270269	cd13551, PBP2_Fbp_like_5, Substrate binding domain of an uncharacterized ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. This periplasmic domain (Fbp) has high affinity for ferric iron and serves as the primary receptor for transport. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.88682e-125
NZ_CP004078.1\|WP_025332669.1\|137450_138389_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.72612e-169
NZ_CP004078.1\|WP_025332666.1\|128235_128502_+\|pro-sigmaK-processing-inhibitor-BofA-family-protein	gnl\|CDD\|377835	pfam07441, BofA, SigmaK-factor processing regulatory protein BofA. This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein.	0.000272506
NZ_CP004078.1\|WP_025332668.1\|136085_137207_+\|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC	gnl\|CDD\|236947	PRK11650, ugpC, sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC.	3.8271e-180
NZ_CP004078.1\|WP_025332658.1\|119697_120951_+\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|183779	PRK12830, PRK12830, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed.	0
NZ_CP004078.1\|WP_025332667.1\|134885_135983_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	7.82594e-16
NZ_CP004078.1\|WP_025332671.1\|139442_140096_+\|pyrophosphatase-PpaX	gnl\|CDD\|237336	PRK13288, PRK13288, pyrophosphatase PpaX; Provisional.	6.52409e-82
NZ_CP004078.1\|WP_025332670.1\|138401_139439_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.12265e-106

>NZ_CP004078.1|WP_025332666.1|128235_128502_+|pro-sigmaK-processing-inhibitor-BofA-family-protein
MKIVASGILILSAVLLVAVVFKKRLGWGWLGLFGSHLILAAIGLYIVDFTHLAGGVYIPLNPATIGTVSVLGLPGVAMLVGLKITLFG
>NZ_CP004078.1|WP_025332665.1|127954_128206_+|hypothetical-protein
MGWLNGLRRQNGKEQEEAQEEHWDVFTEVRKAHMEWERAHLMFDEAVGQDQIDYAIFILEAAERKYQIHLKHAKRIGLNRDRL
>NZ_CP004078.1|WP_025332664.1|127147_127747_+|recombination-protein-RecR
MYYPEPLAKLIDAFTRLPGIGPKTAARLAFHVLNMKEDEVIDFAKALVSVKRNLHYCSVCCNITDTDPCRICQDKTRDASVICVVQDSKDLVAMERTKEFNGFYHVLQGAISPMEGVGPDDIRLKELLTRLSDERVQELILATNPNIEGEATAMYISRLVRPFEVKVTRIAHGLPVGGDLEYADEVTLSKALEGRRELF
>NZ_CP004078.1|WP_025332663.1|126795_127107_+|YbaB/EbfC-family-nucleoid-associated-protein
MNNMNQMMKQVKKMQEQMLKAQEELGSKTVEGSSGGGVVTVQVNGHKKVLSIEIKPEAVDPEDVEMLQDLVLTAVNDALAKAEELASSDMGKFTGGMKIPGLF
>NZ_CP004078.1|WP_025332662.1|124989_126741_+|DNA-polymerase-III-subunit-gamma/tau
MEHIALYRAWRPQAFQDMVGQQHIIQTLQNAIREQRVSHAYLFSGPRGTGKTSAAKVLAKAVNCERGPGPEPCNECPSCLRIASGAVMDVQEIDAASNRGVEEIRDLRDKVKYAPTEVRRKVYIIDEVHMLTTEAFNALLKTLEEPPAHVMFILATTEPHKLPATIISRCQRFDFRRVSLEEQTARLRVICEKEGISAEDDALQYIARLSDGGMRDALSVLDQISSFTDGHVTYQQVLGMTGGIPAEQFARLAKAILESDMGGLLELVEQLMHEGKSADKCLENLLYYFRDLLMIKMVPGSASLTDRVLNPAEFQDMAQAFSRDRLFEIVDTLNRYLSEMKYATHPQTLFEVALMKLCSPKESNDTPVTQARLSGASPADQGELDVLKRQIAALEKKLEQALQSGGIAANGRESGAPKPAAGRSSSAPRISSVSKLPPQMDKFIAGKDSGDFGAVYKQWGQVLQSVKEEKVTVHAWFVDGEPVSVTDDAVLVAFKNTIHRETTEKPANKQVIERVLETRLGKPYRLVTVMLRDWSEASVNSPKPPDQEELRLEHEHEAGEAPKEPWIDEAIQLFGEDLVVIKD
>NZ_CP004078.1|WP_025332661.1|124197_124395_+|50S-ribosomal-protein-L31
MQTAIQPKYNLVTVTCACGNTFEAGSVKQELRVEICSACHPFFTGKQKFLDAGGRVDRFKKKYGI
>NZ_CP004078.1|WP_025332660.1|122787_124065_+|radical-SAM-protein
MHLVYADGQGNVYDHPELHGLARSGDMIVELLEEELIPLPEGATLSLLPNTRAVGMNPATGEMLRLPEGSQAVGALLPQGYTRLCLPGYVKTDKSYKLPLFGYTAVVWKDGGFYVAAEKTDDPFKWNPLNCDRAAVRSGVAALTAKYPENRLYGHLSNCALGYECLTSSNTFLSRWEGGVPVSYSCNAGCFGCISEQPDDSGFVSPQTRMNFRPRVDEIVQVMLEHLKTPESIISFGQGCEGEPSTQAKLIIEAIREVRSITDMGYININTNAGLSDHIRGIVDAGLDLMRVSTISALDDHYNAYYKPRGYSLASVEKSLKYASSQGVYASINYLVFPGVTDREEEVEAMVEFVRRTGLKLIQMRNLNIDPESYLELIPPPQGEVLGMKTMLDIFREELPEVVIGSYTHVPPTGEARTKRAIARL
>NZ_CP004078.1|WP_025332659.1|121410_122766_+|transcription-termination-factor-Rho
MDLQISDLEEMKLTELYKLAKKYQIPYYGQMKKRELIFAILRAQAEQSGLMFMEGVLEILPEGYGFLRPINYLPSAEDIYISASQIRKFDLRTGDLVSGKCRTPKENERYFGLLQVNAVNGENPATAAERLHFPALTPLYPQDKLSLEATPTHLSTRIMDLLAPVGLGQRGLIVAPPKAGKTLLLKEIANSISSNNPEIELFVLLIDERPEEVTDMQRSVKGEVIASTFDELPENHIKVAELVLQRALRLVEHKKDVVILLDSITRLARAYNLVVPPSGRTLSGGIDPAAFHRPKRFFGSARNVEEGGSLTILATALIDTGSRMDDIIYEEFKGTGNMELHLDRKLAERRIFPAIDIRRSGTRREEVLLSKEELDTIWTIRKNMNDSYDFVENFIKKLRNTKTNAEFLASFDTSENKESASGTANSGGTSNSGASARRPMRAKAASVTTTT
>NZ_CP004078.1|WP_025332658.1|119697_120951_+|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MEKLMIGGGRPLQGMVTISGAKNSAIALIPAAILAESEVVLDNLPSLSDVAVYSEILQELGAKVVWSDSQMRIDPSQIISIPMPNGPVKKLRASYYMMGALLGRFKEATIGLPGGCNFEPRPIDQHIKGFEALGATVTNEHGAIHLYAKELRGAKIYLDVSSVGATINIMLAASRAKGSTIIENAAKEPEIIDVATLLNSMGAIIKGAGTETIRIEGVPEMHGCRHSIIPDRIQAGTYMIAAAATRGNVLIDNVIPKHLEALTAKLLEMGVEVEELDESIRVIGKAVYEPADVKALVYPGFATDLQSPMTTMLTQAKGVSVLSDFVYSNRFKHVPELLRMGAKIRVEGRSAIIEGNKLNAAKVRAADLRAGAALVIAGLTVEDGITEVTGVEYIDRGYDNLVPNLRELGAEVWREEE
>NZ_CP004078.1|WP_025332657.1|118607_119462_+|class-II-fructose-1,6-bisphosphate-aldolase
MPLVSMTDMLNKALAGKYAVGQYNINNLEWTQAILGAAEEEKSPVILGVSEGAARHMGGFNTVVKMVEGLIQDMNITVPVTIHLDHGSSFEKCKAAIDAGFTSVMIDGSHHPIEENIEMTKQVVNYAHSKGASVEAEVGTVGGQEDDVIGGIMYAKLEECVAIVKETGVDALAPALGSVHGPYLGEPNLGFKEMEEVRDAVKIPLVLHGGTGIPKHDIDKAISLGTSKINVNTENQIAFAKVVREVLAAKPDAYDPRTFIAPGREAIKQTVIGKIREFGSNNKA
>NZ_CP004078.1|WP_025332667.1|134885_135983_+|helix-turn-helix-domain-containing-protein
MDTETLRQKMEHLTGKKSGIKQFGRQQSASLFRVEPKAVQQSVLFEGSVWIPLYESEGRITALSIETEGLSEMEQQLAQFAAENYAAALRASGFKEEGEAEARQLGAWLNTQLERNLDDGEISDEIALKSRLFTDMVPFLLVGENTHSSDIAYRSLLKLIRSYFDNTTLLIPLQTKEWLILARKDLLTGTEEKDEQEESDDEELLAQACMGLHELIASEWVGVFHVSVSSSIIPLKGLAGVVTLLRETISLGRIFEVGEYIHLPWALQLERLVNSIPDGRRRQLLAQFGDYTTVLSDKEMLVTLETFFQMDCNVSETAKKLYIHRNTLLYRLDKIKQETGADVRSFGDAAIVKLTMLLYKVTKRK
>NZ_CP004078.1|WP_025332668.1|136085_137207_+|sn-glycerol-3-phosphate-ABC-transporter-ATP-binding-protein-UgpC
MAGVRLEHVFKKYPGSDKATVIDVNLDIKDKEFLVLVGPSGCGKSTTLRMIAGLEEISEGKLFIGDRVVNDVAPKDRDIAMVFQSYALYPHMSVYQNMAFGLKLRKVKKDEIDRKVREAAKILDIEHLLERKPKALSGGQRQRVALGRAIVRDPQVFLMDEPLSNLDAKLRGQMRAEITKLVKRLETTCIYVTHDQTEAMTMGDRIVVMQDGIIQQAASPEELYNNPKNLFVAGFIGSPTMNFISGTLSEVSGAVRFTADNLDVEVPGGKAQLLRSKGYIGKEVVMGVRPEDIHEEPVFLEASPNTIFSALVDVTENLGHEMLLYLSGIGKDSVIARVDGRSTTREGSKAKLAIDMNKVHLFDKQSELNILLG
>NZ_CP004078.1|WP_025332669.1|137450_138389_+|HPr-kinase/phosphorylase
MAKKVKVSELVQHFQLEVISGQEGLKRLITVDDLNRPGLEMAGYFEYYPEDRVQLMGKTELAFFSMLPAEERISRIRGICHDETPCIVITRGLDVPQELIDVSNEKGLPVLRSSMATTIFSSRLTSFLEGRLAPTATIHGVLCDVYGVGMLITGSSGIGKSETALELVKRGHRLIADDAVEIRQTSDNQLHGTAPELIRHLLEIRGVGIINVMTLFGAGAIRNHKRITLVVKLEAWQQDKQYDRLGLDEETTRIIDTDVPLVTIPVRPGRNLAVIIEVAAMNYRLKQMGFNAALQFTHKLTATISEDMDDLD
>NZ_CP004078.1|WP_025332670.1|138401_139439_+|prolipoprotein-diacylglyceryl-transferase
MFPLALDPIAFSIGALKVHWYGLILGLGALTGLFLVIREGRRFGIPQEFFMDLLLLGVPSAIIGARIYYVAFTWDEYKNNFVDVFKIWNGGIAIYGALIGAIICAIIYFRYKGYPFWRIADICAPGLLAGQMIGRWGNFVNQEAYGGPVHETFLRNSLHLPDFIVNQMYIEKDLAYHHPTFLYESLWSLVGIVLLMVLRRQRVIRAGELFLSYFIWYSIGRFFIEGLRTDSLAFKGSDALASFINGLWSPMKGLGFEAGYLNPNYGNIRTSQLLALLIVIAAILLIIIRRMTGAAKAHYSDPIVSTKQQAADPVLTEQEGKPEHNAPAPPSAHNHPPLEEEKKEH
>NZ_CP004078.1|WP_025332671.1|139442_140096_+|pyrophosphatase-PpaX
MIEGILFDLDGTIVNTNELIISSFMYALEQHSQPALTREQMIPHMGTSLLDQLRAFTSLQDVTALEASYRLFQNEHHDELIRSFPNVNETLEGLRSRGIKLGVVTTKIRPTTIRALEMFDLLQYMDTIVTLNDVTNLKPHPEPVLTGVNNLGLSPEKTLMVGDSVVDIQSAKAAGVRAAGVAWSLKGEDTLRKYEPDYILQDMADLYEIVGEGTAGR
>NZ_CP004078.1|WP_025332672.1|140092_140581_+|acyltransferase
MSRKITRYPVEGPNSLWHIYRTVSPLKGVKNFIFIQIARYCPILPLKNWIYRRVLGMKVGKHTAFGLMAMVDVFFPELITVGDNSIIGYNTTILAHEYLIWEYRLGEVVIGENVMIGANTTILPGVTIGDGAIVAAGSVVHKDVPAGAFVGGNPLRELKKSQ
>NZ_CP004078.1|WP_025332673.1|140692_141868_+|acyltransferase
MGQKERIPQLDIFRAISIFAVVAIHATSRTLAETLNTPLFHPFLFINKFSQFAVPSFVFLSGFVLFYNYIDRPLTGRTLGKFYSRRLIYILVPYAIFTLLYFVLRLYAGNQWSLPPQEMAAKIAKYALTGTAYTHLYYVIIIIQFYVLFPLLLWALQKSRRLAAWAPLIGLALQWGFVVLNKYMVNHGYWHVSKGSLAITYFSYFLLGAAIAVFYSSLKPWLIPWEDRKRRGPWLLWAVLWVAWLAAGIAHVELWNRNYTQKTVINSFWFEGAANAHALLSCLLLFQLSFLLFGAGRRLGSRLLISAGVCSFGIYLVHPAMLFFYRKIEFHGGYLAYVLAIAGGWLASLVLSWIIVALAFRFIRPAWILFGSAPGRPARQMQKVRQEHNGV
>NZ_CP004078.1|WP_025332674.1|142472_143624_+|GntR-family-transcriptional-regulator
MRSAGARTQLYLQVADKAWEIICSRKLQPHDPVPSEGELAKLYGVSRMTGKLALEHLAEQGLIYRLPRRGSFLAGKREETVDADAASAEQAVAAAARTAGKQIALILPHLSEYTSRIIAAVESEVRKHDFDLILQISKDKDDEDRGLQKLAASGVGGVILFPQGRKTCSDQVLRLKLEQLPLVIIDRIFREVQIDCVYHDHYRGSYEMAQYLIGKGHREIGYTSNMSENITSREERYQGYIQALLDHGIPVRNEYIHFRSVPCDPGRINESDPEQEQFIARSPQMTAVMCGDDHVAATTLFTALHMGIPVPDKLSIVGFSDIQLSALTPVPLTTVRQDTERLARSAVDLLMKRVNRSKEKQLTIKIQTAITERKSVLDRGVLL
>NZ_CP004078.1|WP_025332675.1|143620_144439_+|carbon-phosphorus-lyase
MKIHFLGTAAAEGFPNAFCRCEFCIKARELGGRNIRTRSSAIIDDTIKFDYSPDSYMQALRDGLDFGAIEHLLVTHTHSDHLNAYDLECRRAGIAHGLEHPLHIYGNDCVMHQVRTAIGRFEGERFAFHRLHPFRTFTMGEARVTPLLADHDRMETCLLYVVEKGGKKLLYGHDSGWYPEPTWEWLREQELDGAILDCTHGYTGNSRDCNHMGVETVLETQREFRLHRIIKPEGTIVVTHFSHNSRLLYDDFDAIFRPVGIITAYDGLIINL
>NZ_CP004078.1|WP_025332676.1|144468_145593_+|extracellular-solute-binding-protein
MKKVLKMACIAILCLAATACGNGSNGGNGGNGAAGGTTRPSDAAAASAAPENTASANDKLIVYTNANSDGRGEWLIAEAGKAGFDIELVGAGGADLTNRLIAEKNNPTADVVYGLNNMLYENLKKENILARYVPKWAGEVEEGLSDPEGYYHALVKQAILLGYNPEAFTPETAPKDWTELYQNDAYKGKYEAPTLLGQMTPRLVVAGILTRYTDPSGDLGISEEGWNAVRQLYDNGVPAVEGEDFYANLASGKTPLGAVVSGTLAKKEDQYKVKAGIVSPEIGVPVIVEQAAIVNGTKKQATAERFVDWLGSAEVQGAFAAQFKAMPANKQAAEQADPAIKALYSTLKTQPLDWAFLADHIDQWVEKIELQIMK

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP004078_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP004078_2

286209-286413

Orphan

Consensus_repeat	Method
GGCCGGTTCCCCGGCCCCGCCCGCCGTGCCGCCGGTGCGCCCATGGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP004078_2

>merge|NZ_CP004078|2|286209-286413|CRISPRCasFinder
GGCCGGTTCCCCGGCCCCGCCCGCCGCGCCGCTGACGCGCCCATGGCGGTCTACGCCGCCGCCATGCCCGCTGCGGCCGGCCGATTCGCCGGCCCCGCCCGCCGCGTCGCCGGTGCGCCCATGGCGGTCTGCGCCGCCGCCATAACTGCCGCGGCTGGCCGGTTCCCCGGCCCCGCCCGCCGTGCCGCCGGTGCGCCCATGGCGG

>NZ_CP004078|2|2|286209-286413|CRISPRCasFinder
GGCCGGTTCCCCGGCCCCGCCCGCCGCGCCGCTGACGCGCCCATGGCGG	TCTACGCCGCCGCCATGCCCGCTGCGGCCGGCCGATTCGCCGGCCCCGCCCGCCGCGTCGCCGGTGCGCCCATGGCGGTCTGCGCCGCCGCCATAACTGCCGCGGCT
GGCCGGTTCCCCGGCCCCGCCCGCCGTGCCGCCGGTGCGCCCATGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP004078.1\|WP_025332796.1\|289884_290490_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|235811
NZ_CP004078.1\|WP_025332800.1\|293328_294018_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP004078.1\|WP_025332802.1\|296121_296541_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025332788.1\|280763_281807_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP004078.1\|WP_025332803.1\|296544_296742_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224393
NZ_CP004078.1\|WP_025332784.1\|276774_277170_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|173926
NZ_CP004078.1\|WP_038596344.1\|279223_280489_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340891
NZ_CP004078.1\|WP_144240447.1\|284922_285138_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025332785.1\|277430_278672_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377924
NZ_CP004078.1\|WP_025332793.1\|285424_285661_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_038595461.1\|294010_295099_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP004078.1\|WP_025332790.1\|282705_283251_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP004078.1\|WP_025332786.1\|278702_279194_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025332791.1\|283285_284734_+\|aryl-sulfate-sulfotransferase	unknown	unknown	gnl\|CDD\|368677
NZ_CP004078.1\|WP_025332799.1\|292199_293219_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380632
NZ_CP004078.1\|WP_025332797.1\|290458_291178_+\|YhfC-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|337619
NZ_CP004078.1\|WP_025332798.1\|291272_292073_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025332789.1\|282019_282418_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025332795.1\|288920_289730_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP004078.1\|WP_025332801.1\|295205_296030_+\|D-Ala-D-Ala-carboxypeptidase-VanY	unknown	unknown	gnl\|CDD\|350624

Protein	Function_ID	Function_description	E-value
NZ_CP004078.1\|WP_025332788.1\|280763_281807_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	2.17317e-32
NZ_CP004078.1\|WP_025332803.1\|296544_296742_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	2.41643e-25
NZ_CP004078.1\|WP_025332796.1\|289884_290490_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|235811	PRK06474, PRK06474, hypothetical protein; Provisional.	7.46061e-41
NZ_CP004078.1\|WP_025332800.1\|293328_294018_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.99013e-89
NZ_CP004078.1\|WP_025332784.1\|276774_277170_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	1.54885e-12
NZ_CP004078.1\|WP_038596344.1\|279223_280489_-\|MFS-transporter	gnl\|CDD\|340891	cd17333, MFS_FucP_MFSD4_like, Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins. This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.29912e-27
NZ_CP004078.1\|WP_038595461.1\|294010_295099_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.05416e-46
NZ_CP004078.1\|WP_025332790.1\|282705_283251_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.40723e-14
NZ_CP004078.1\|WP_025332785.1\|277430_278672_+\|hypothetical-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	2.04489e-08
NZ_CP004078.1\|WP_025332791.1\|283285_284734_+\|aryl-sulfate-sulfotransferase	gnl\|CDD\|368677	pfam05935, Arylsulfotrans, Arylsulfotransferase (ASST). This family consists of several bacterial Arylsulfotransferase proteins. Arylsulfotransferase (ASST) transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate.	4.55633e-24
NZ_CP004078.1\|WP_025332799.1\|292199_293219_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|380632	cd19977, PBP1_EndR-like, periplasmic ligand-binding domain of putative repressor of the endoglucanase operon and its close homologs. This group includes the ligand-binding domain of putative repressor of the endoglucanase operon from Paenibacillus polymyxa and its close homologs from other bacteria. This group belongs to the LacI-GalR family repressors and are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding.	2.18839e-118
NZ_CP004078.1\|WP_025332797.1\|290458_291178_+\|YhfC-family-intramembrane-metalloprotease	gnl\|CDD\|337619	pfam10086, DUF2324, Putative membrane peptidase family (DUF2324). This domain, found in various hypothetical bacterial proteins, has no known function. This family appears to be related to the prenyl protease 2 family pfam02517, suggesting this family may be peptidases.	6.3538e-07
NZ_CP004078.1\|WP_025332795.1\|288920_289730_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.2237e-33
NZ_CP004078.1\|WP_025332801.1\|295205_296030_+\|D-Ala-D-Ala-carboxypeptidase-VanY	gnl\|CDD\|350624	cd14852, LD-carboxypeptidase, L,D-carboxypeptidase DacB and LdcB, and related proteins. This L,D-carboxypeptidase family includes LdcB LD-Carboxypeptidase from Streptococcus pneumoniae, Bacillus anthracis, and Bacillus subtilis, and L,D-carboxypeptidase DacB from Streptococcus pneumonia and Lactococcus lactis. These enzymes are active against cell-wall-derived tetrapeptides and synthetic tetrapeptides lacking the sugar moiety but are inactive against tetrapeptides terminating in L-alanine. L,D-carboxypeptidase DacB plays a key role in the remodeling of S. pneumoniae peptidoglycan during cell division. It adopts a zinc-dependent carboxypeptidase fold and acts as an L,D-carboxypeptidase towards the tetrapeptide L-Ala-D-iGln-L-Lys-D-Ala of the peptidoglycan stem. This family also includes vanY D-Ala-D-Ala carboxypeptidase which is vancomycin-inducible and penicillin-resistant. VanY hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors; it is insensitive to beta-lactams. All these enzymes belong to the MEROPS family M15 subfamily B.	2.95031e-57

>NZ_CP004078.1|WP_025332793.1|285424_285661_+|hypothetical-protein
MEPTAQDVAEWMVKEIRFTGTLYQADAIDYVKRNFGEQFVFVNENGNASLSKEVKKAFRKLHRGRIAWDRDGFLWAWT
>NZ_CP004078.1|WP_144240447.1|284922_285138_+|hypothetical-protein
MFPDNLNAKDDSEWVEAPRSEDAPQEQRGRSERIAEESRQGSSLNFFNAFVALGTTVSVIMLFVWLMNLIR
>NZ_CP004078.1|WP_025332791.1|283285_284734_+|aryl-sulfate-sulfotransferase
MGFPTVYPTGATVYNPSKAWSGYTVYQAGDEGVVLIDMNGREVHLWRGLIGFPAKALPGGYVLGSTGRRDPKFGIQDNVDLVQVDWDGNIVWRYNGYEHIEDPGYEPTWYARQHHDYQREGNPVGYYAPGLEPEVSRGTTLILAHKNVNNPAISDKQLLDDVIIEVDWEGNVTWEWKASDHFDELGFDESARNVLFRDPNTRSFGHLGGGVGDWLHVNSASYVGPNRFYDEGDERFHPDNVIWDAREANIIAITDRRTGSIVWRLGPDYSLPEVKHIGWIIGQHHAHIIPKGLPGEGNLLVFDNGGWGGYGLPNPASPFGQKNAIRDHSRVLEINPVTLEIEWQYTGAEAGFSVPTDSYKFYSPYISSAQRLPNGNTLITEGSNGRLFEVTKDHEIVWEYVSPYTDRRNTNMVYRSYRLPYEWVPQLAKPEEIAIEPIDAAQFRVPGAAPKGSDSVVNVAAALPFVEGAACVATSDEARRRA
>NZ_CP004078.1|WP_025332790.1|282705_283251_+|MarR-family-transcriptional-regulator
MENRDWDVLEEADWLFRKMVRRFVKERDRINVEGIALPGMMILHKIIREGDQRLSDLAEQLDLTSGAITALCDKLDTAGYTIRRRKSGDRRTVLLGITDKGREMFERNRSVGTRCISLLFEGFEREELAAQNQAFKKVIGNLEGFSEAILDLAKQNAGTPAQGSPERKPARVTTQTRYLTY
>NZ_CP004078.1|WP_025332789.1|282019_282418_-|hypothetical-protein
MNITRNIKRVVIVGTMIVAISFGGNAWASKSVSSSPVAKLSLSAAAAGRDDLLETLNRPSGEELYYALFEGKSLADIAEANGADVQQVIDLQTEQLTKQLDERLASGSITKEQYEAYSEEVQEIISRSVDPD
>NZ_CP004078.1|WP_025332788.1|280763_281807_+|AI-2E-family-transporter
MEWFKHFFADLTVRRFGILLLVCLLLYGIRDMLNLVLLTFLIAYIMNSFQVLLSRRIGRYVRVNSKVIIIILYVVMISTLVTALVHYLPKIFVQVRQLTNFLIALTPENIPQNEIVQYLFKTVKGLNYEKYMTNGLDYITTIGNWGTTFVLSIILSFVFILEKNRIVAFTSRMKQSKVAWFYNELEYFGNKFALSFGKVIEAQILIAMFNTIFTVIGLIILGFPYLFALGVMIFLLSLIPVAGFLISLIPLCIIGYNIGGLVMVIYVLAMIAVLHFIEGYFLNPKLMSSKMNLPMFYTFIVLLFSEHYLGVWGLILGIPIFVFVLDILEIKRANAEAELPADPLKKR
>NZ_CP004078.1|WP_038596344.1|279223_280489_-|MFS-transporter
MPKETAQTKTFPASPKRIYILQLLTVFIGFLIFGFSENIKGPAIPRIQLEMGLDEMRIGLLLSLNSLGYLLACSFTAYLIRRIGIKAVCLLSFGSMVLSGVLIFLSRSYPALSSSFFLMYIGNGMLEIGLAVLAARIFIRNTGTMMNLAHFFYGLSSTVAPMIASGLMTLSIGGRAIDWRDVYLLILLLAILPMIPAVAGKFPSSGISGDERLPLKVLAADPVIWMLVATLSFGVISEMAVGGWLVNFLEKAYGWDGTAAAGMLSVFFLCFTFARLFLGPITDKIGFTLSLIIFSALSGLLTFAAIAAGEPGAFLFAAAGIGIAPIYPTVMALIAKRYGEGSDTAITFIVTLMGVSSVIGNYLIGAIITGIKDMVTASRGAGEGLLAGLQAGYAFIGLCALLCALFAVPLYVYLKRRGELL
>NZ_CP004078.1|WP_025332786.1|278702_279194_-|hypothetical-protein
MRKWFLSGFAGLLAAVILTSCAKNDVTGIQESSGPSPSSTPVQKESSEFFKAGVFVNVGDSSEPLLNQEIKSRLKTVLTSMANKDAEAFRSVFTDDRSGSAQLYLLNRDYAFNQLGTVRQDYANRIEVQVIGKVMQDAVITDQYLYFYFVKNAKGHWYLGAID
>NZ_CP004078.1|WP_025332785.1|277430_278672_+|hypothetical-protein
MTVKKVPKPAVWLVLFAFLAEAVVIPVRDVKVSAAGAEPIVPAASALTAFGAVSSTDAVRFDLIKHEMRINLSGGEASLDGKAVKAATPIKRNDRLYVPLRALGESGAVSSVAWNSAKRQVRVVSRREELNFRIGSTRVYDGQGKALPAENFTIPAPLLIGGTAYVPVCSLTLFGLTAGAENGQLFWRWSEKKAQVLQPYWETGEDEAVFTVLYAKELYAPGAGSSIGSGAWNSSRNIVGKDIYLDGSLYNRIQLSVPLEPGINPVAISSIGMAAAGIRIRRNVSDPSVIPVNITEDGKEFLTLESPASGYLKLKSGDSFTISGKVINPPNLAIGKLTVTIQRYVPDAEDVRKDFTTVSTKEIPVKNGTFSGSVTLPRSGSYRICVNGLTYTTFPGHGPASVTWANLSAEVAE
>NZ_CP004078.1|WP_025332784.1|276774_277170_-|GNAT-family-N-acetyltransferase
MNPITIRKAESDDVAGLSELFVDFNGKESNLTAMKKQLEVISANPDYYVAVAYDGDRVIGTAMGIACYDLVGDCNSFLLIENVVVLPKYQGQGVGKLLMQALEDFGEINHCKYVILVSESKRESSLEHSPT
>NZ_CP004078.1|WP_025332795.1|288920_289730_-|alpha/beta-hydrolase
MQYYIETEPGVKLFVEDIGSGIPVVLLHGWPLDHRMFEYQVTHLPKYGYRCISIDFRGYGQSDNPWEGYTYDRMADDVRAVLDTLRLSDVRLAGFSMGGAVALHYAARHRGCRLSQLLLLAAAAPKFARGADYPYGMPVTAINQLLAGVYTDRPQAVASFGENFFAKPVSPAFREWFQSLCVTPSNHGTAGGVMMLRDEDLRPDLPLIQVPTVIFHGVLDQICPFEFARLMHQGIRGSQLLAFEHSGHAVFYDELELFNQRLIQVLGGR
>NZ_CP004078.1|WP_025332796.1|289884_290490_+|helix-turn-helix-domain-containing-protein
MAQSKADLILHPIRMRIIQALVNGRRRTTQQLVKELEDIPQATMYRHLNKLLKAGVLEVAEENKVRGAVEKVYYLSQGGEDATPADTTERAAGEHMAFFLKFASSLIGDFSAYVQQEKYDMRQDGVSIRQVQLYLTDEEYAQLLEDMRRPMQKYAGNESGEGRRRRMISTIVIPGALSGLTGGADEGEEQNDVGRANEEGN
>NZ_CP004078.1|WP_025332797.1|290458_291178_+|YhfC-family-intramembrane-metalloprotease
MLAEQMKKETSVENPANDPFAGLTGRTLKFVPLYLLVPVLYGVLFRAAGIPLQWKVFGLGALGWLAALFLRGPLAALVRGLPQERAKLIVGGSSGVLEEGVRLALLSLLAASFPQALSLGQGWAAIEVLFVIVNTLVILSLVKRTDEKAMQAKEILQAQGNLQASPLWGILERIWASAFHIGAALIIAHTPWTAALMIPLHSGFNLGAVRLAKAAPLPVVSLYAAAFGLLTLAAGLLLW
>NZ_CP004078.1|WP_025332798.1|291272_292073_+|hypothetical-protein
MSRTLEGPAIDVLIPAIEKDLATLPHVVDAVRKQVRHPIRSVMIVAPRKERILDFCRRKACTFVDENTVLPITKKDINYRSRTWERSGWLFQQLLKLGGDKLCTADYFLVIDADTVLIAPHRFRTGGKTIFYCRNWSQPEYFTTYRKLMGRKAVRPSSFVTHYMLFERSRLSRMKREIEAKHGVPWYTAIMRSMNRTRQFAFSEFETYGNYLYAKNPGGMVLKKARNKSLSMSGSNLSTAAAAKYARIYRSLSFHKRKGYSRTSKP
>NZ_CP004078.1|WP_025332799.1|292199_293219_+|substrate-binding-domain-containing-protein
MVRATIGDVAARAGVSKSTVSQYLNKRYQHMGAETRAKIEEAIKALDYQPNVLARGLKQKRTSTLGVIVANIMHRLSTEICRGIEDYCQEQDINVILCNSDEDGEKEKKYAEMLQAKQVDGMILLPTGKNGSLYKKLARHRYPILFMDRKVDSVKADTIVVNNRESVYEAVSHLKERGHRRIALATAPLTISTRTERTEGFRQAMSDHGLEYGRYIINAEISSLRRRFRELFDGPEPPTALIAGNDLVLLEALAFVKERQLRVPEDLALVAFDNIEFAHLLTPTLTTISQPSIEMGRRAAERIISRIRSEEDLTPEEYVFKCELAVRQSSEMKRSKSTS
>NZ_CP004078.1|WP_025332800.1|293328_294018_+|response-regulator-transcription-factor
MDRITILIADDDPEIAELIALHLKKEGYRPIKAADGEEAVNAVKSRRIDLAILDIMMPGLDGYEVTRQIRERYLFPIIFLSAKTSDLDKITGLVMGADDYMTKPFNPMELMARVNTQLRRSRLLSPSAAANNRQVEAGGLIIDPDKHSVTLYGNPVKLTPKEFDILYLLAAHPRQVFSADHIFRQVWGDGYYEGGNTVMVHVRTLRKKLGEEPNRWIKTIWGVGYIFNG
>NZ_CP004078.1|WP_038595461.1|294010_295099_+|HAMP-domain-containing-histidine-kinase
MARRFLSFRSKMILLLGFSMLLSGVVTFLLYKVLQYYYYENARAGDSLSRFRLMIRNVGDLNFFLIFFVPLAILVFFFLTKPYAVYFNEISAGIHRLASGDFKDRVQISSNDEFEKIAQDINLAGEKLQQAVERGDFAESSKDQLILNLAHDLRTPLTSVLGYLDFILRDRQLTADQVQHFASIAFTKSRRLEKLINELFEIAGMNHGKLAIQKKPLELSELLRQLNEELYPIFENHHLTARLSVPPKVNILGDGELLARVFENILTNAARYGRDGQFIDISCTHDEEAAIVQIVNYGDPIPEEERPYIFDALYSGDRSRTHQGGSTGLGLFIAKNIVEQHKGTISVQSDIIRTLFEVRLPK
>NZ_CP004078.1|WP_025332801.1|295205_296030_+|D-Ala-D-Ala-carboxypeptidase-VanY
MKKWFLALALLLLTSCEQGREIVIRETNDHAGNIPVKVTEEQVYQGDLLLVNKEYSLHKVGIQPDIVNLYGYKELTQGYALLDHTIRLSQRVAREFSVMIGAAEGDGVRHFMISSGYRSLDEQDRLYQEKGADYALPSGHSEHNLGLSLDIGSTEMEMNRAAEGKWLEKNAWKYGFILRYPKDKTDITGIQYEPWHFRYVGLPHSLIMKDKNFTLEEYLDYLKTKRTISIETGGKSYEISYVPIAKDTVIYILEGRRYSLSGDNIGGVIVTTSR
>NZ_CP004078.1|WP_025332802.1|296121_296541_-|hypothetical-protein
MKNGSAVRNAGALALGILLLAAGLLEVGDMARNISGVCAGLGAGLIGMSISNLFIIRYYAKHPALKKQHEIEAGDERSVSINNLSKAKAFDITIRAMMLIPFVLILADSPLWLTLAVVAFYVFSYSIRYYYIVKYSKVM
>NZ_CP004078.1|WP_025332803.1|296544_296742_-|helix-turn-helix-transcriptional-regulator
MKNRLEEIRKQHGIKQEELAEALAVSRQTIGSLENGRYNPSIILAFKIARYFKLSIEEIFIYEEE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP004078_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP004078_3

2836963-2837054

Orphan

Consensus_repeat	Method
GAGTTTTGTACGGAGTTGAACCTTGATGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP004078_3

>merge|NZ_CP004078|3|2836963-2837054|CRISPRCasFinder
GAGTTTTGTACGGAGTTGAACCTTGATGTACCGCTCACAAAACTTGGCGGATGCTTTCGAAGCGAGTTTTGTACGAAGTTGAACCTTGATGT

>NZ_CP004078|3|3|2836963-2837054|CRISPRCasFinder
GAGTTTTGTACGGAGTTGAACCTTGATGT	ACCGCTCACAAAACTTGGCGGATGCTTTCGAAGC
GAGTTTTGTACGAAGTTGAACCTTGATGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP004078.1\|WP_013308297.1\|2847901_2848264_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380355
NZ_CP004078.1\|WP_025335011.1\|2835966_2836335_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|223672
NZ_CP004078.1\|WP_051529766.1\|2834297_2835941_+\|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl\|CDD\|223107
NZ_CP004078.1\|WP_025335012.1\|2836549_2836891_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025335016.1\|2844283_2844871_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP004078.1\|WP_025335020.1\|2848489_2849353_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176133
NZ_CP004078.1\|WP_025335009.1\|2833413_2833716_-\|Dabb-family-protein	unknown	unknown	gnl\|CDD\|214884
NZ_CP004078.1\|WP_025335019.1\|2847125_2847683_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379082
NZ_CP004078.1\|WP_025335015.1\|2839883_2844095_+\|sulfite-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|239155
NZ_CP004078.1\|WP_025335021.1\|2849814_2850645_-\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|179310
NZ_CP004078.1\|WP_025335008.1\|2831286_2832762_-\|YdiU-family-protein	unknown	unknown	gnl\|CDD\|234583
NZ_CP004078.1\|WP_025335005.1\|2828187_2829447_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025335003.1\|2826453_2827026_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP004078.1\|WP_025335018.1\|2846474_2846894_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133384
NZ_CP004078.1\|WP_025335014.1\|2838616_2839849_+\|NarK/NasA-family-nitrate-transporter	unknown	unknown	gnl\|CDD\|225133
NZ_CP004078.1\|WP_025335007.1\|2830328_2831108_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP004078.1\|WP_025335004.1\|2827050_2827986_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025335017.1\|2845160_2846354_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP004078.1\|WP_025335013.1\|2837084_2838077_+\|3-oxoacyl-ACP-synthase	unknown	unknown	gnl\|CDD\|238426
NZ_CP004078.1\|WP_025335006.1\|2829520_2830336_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|272905

Protein	Function_ID	Function_description	E-value
NZ_CP004078.1\|WP_013308297.1\|2847901_2848264_-\|cupin-domain-containing-protein	gnl\|CDD\|380355	cd02226, cupin_YdbB-like, Bacillus subtilis YdbB and related proteins, cupin domain. This family includes bacterial proteins homologous to YdbB, a Bacillus subtilis protein of unknown function. It also includes protein Nmb1881 From Neisseria meningitidis, also of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.56256e-49
NZ_CP004078.1\|WP_025335006.1\|2829520_2830336_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|272905	TIGR00099, Uncharacterized_protein_MCAP_0867, Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily. This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity].	2.80661e-51
NZ_CP004078.1\|WP_025335011.1\|2835966_2836335_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|223672	COG0599, COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown].	1.93681e-14
NZ_CP004078.1\|WP_051529766.1\|2834297_2835941_+\|thiamine-pyrophosphate-binding-protein	gnl\|CDD\|223107	COG0028, IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism].	1.68476e-143
NZ_CP004078.1\|WP_025335020.1\|2848489_2849353_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176133	cd08442, PBP2_YofA_SoxR_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold. YofA is a LysR-like transcriptional regulator of cell growth in Bacillus subtillis. YofA controls cell viability and the formation of constrictions during cell division. YofaA positively regulates expression of the cell division gene ftsW, and thus is essential for cell viability during stationary-phase growth of Bacillus substilis. YofA shows significant homology to SoxR from Arthrobacter sp. TE1826. SoxR is a negative regulator for the sarcosine oxidase gene soxA. Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine, which is involved in the metabolism of creatine and choline. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.70039e-66
NZ_CP004078.1\|WP_025335009.1\|2833413_2833716_-\|Dabb-family-protein	gnl\|CDD\|214884	smart00886, Dabb, Stress responsive A/B Barrel Domain. The function of this domain is unknown, but it is upregulated in response to salt stress in Populus balsamifera (balsam poplar). It is also found at the C-terminus of a fructose 1,6-bisphosphate aldolase from Hydrogenophilus thermoluteolus.It is found in the pA01 plasmid, which encodes genes for molybdopterin uptake and degradation of plant alkaloid nicotine. The structure of one has been solved and the domain forms an alpha-beta barrel dimer. Although there is a clear duplication within the domain it is not obviously detectable in the sequence.	1.41473e-24
NZ_CP004078.1\|WP_025335019.1\|2847125_2847683_-\|AAA-family-ATPase	gnl\|CDD\|379082	pfam13238, AAA_18, AAA domain.	3.0157e-05
NZ_CP004078.1\|WP_025335014.1\|2838616_2839849_+\|NarK/NasA-family-nitrate-transporter	gnl\|CDD\|225133	COG2223, NarK, Nitrate/nitrite transporter [Inorganic ion transport and metabolism].	2.07163e-103
NZ_CP004078.1\|WP_025335021.1\|2849814_2850645_-\|membrane-protein-insertase-YidC	gnl\|CDD\|179310	PRK01622, PRK01622, membrane protein insertase YidC.	1.19416e-95
NZ_CP004078.1\|WP_025335008.1\|2831286_2832762_-\|YdiU-family-protein	gnl\|CDD\|234583	PRK00029, PRK00029, YdiU family protein.	0
NZ_CP004078.1\|WP_025335003.1\|2826453_2827026_-\|hypothetical-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	0.00486823
NZ_CP004078.1\|WP_025335018.1\|2846474_2846894_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133384	cd01109, HTH_YyaN, Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB. Putative helix-turn-helix (HTH) MerR-like transcription regulators of Bacillus subtilis, YyaN and YraB, and related proteins; N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.54574e-42
NZ_CP004078.1\|WP_025335015.1\|2839883_2844095_+\|sulfite-reductase-subunit-alpha	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NZ_CP004078.1\|WP_025335007.1\|2830328_2831108_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	3.97257e-88
NZ_CP004078.1\|WP_025335017.1\|2845160_2846354_-\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	2.6456e-79
NZ_CP004078.1\|WP_025335013.1\|2837084_2838077_+\|3-oxoacyl-ACP-synthase	gnl\|CDD\|238426	cd00830, KAS_III, Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.	8.29841e-62
NZ_CP004078.1\|WP_025335016.1\|2844283_2844871_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.14701e-07

>NZ_CP004078.1|WP_025335012.1|2836549_2836891_+|hypothetical-protein
MGKFILKTDSAKKIVNIELEGTFTEEDGLKSIQAYQETINPITPSEYLLDIDCRKLNVTAPDVVPLLEGCFLMFKKDGFDKVKLTLESNPVLKMQLARLGRKAGLENLDIISL
>NZ_CP004078.1|WP_025335011.1|2835966_2836335_+|carboxymuconolactone-decarboxylase-family-protein
MIDNINSGLKHFSNLSGDYGAKALAPIKEHFPELAEYIMGNAYGDVFQRTTIAADWKEIVVISALISMGQFDQLGVHYVMALSVGMTVDQIKGILLHLVPCVGAPRVITAFNVLLATLEEIQ
>NZ_CP004078.1|WP_051529766.1|2834297_2835941_+|thiamine-pyrophosphate-binding-protein
MDLLKTVADYMAEALRNLGVKHSFGIIGKSICPIVLKMVDYGIEFIPGRHESSSGFEASGYALKTGNLAVAFGTSGPGGTNLITAAAHAKANNLPVLFITGHQSIKELGIPQCQDSSSYLADLAEMFRPATLFSKLVERGDHFSTIFNHAISVALSGKRGPVHLCIPFDVQTELLEECRIVYPERETLVDYAKVNRVINAINHSKKPLIIAGKGVNRSGAHEELVQLAETFNIPVVTTPGGKGAIVWDHPLYHGPVGVGGCKHGDDLMNHSDLYIVLGSRLSDMTICNLKAENHPETLIQFDIDPTFVGKILNSHTIAVGGDVRDNLSLILQSVDSSAITERDTETAAHYKEELPVLSKLSLASVMSTMSDLIPSNNTVFVDDGSHGFNAVKWYNVKKPGSFVFDAYFACMGNAIGMAIGAKVASPEETIFCITGDGCFMMLGTEINTAVCKNIPVIFIVVNNMQLDMALKGMEKTTGRIDGTLFEVPMDAVKFAESLGATGFRCETQEQFAAAISEAIALNRVAVIELLTDRDEVPPTAHRVLNLN
>NZ_CP004078.1|WP_025335009.1|2833413_2833716_-|Dabb-family-protein
MYEHLVVFKFNDGLTPAKQQELLDQLLALRDRIPGITDLSAGVNVTEETDNIHGYTLGLRVTFKDLESLRSYGPHPIHQEFVKSLDGLLENVVVVDYPKI
>NZ_CP004078.1|WP_025335008.1|2831286_2832762_-|YdiU-family-protein
MTERAGIPEAGWNFDNSYARLPKSFFSRQDLNPVNSPKLIVLNRPLAASLGLNAEALQSSDGAAVFAGSRIPEGAEPLAQAYAGHQFGHFTMLGDGRALLLGEQITPGGERFDIQLKGSGRTPYSRRGDGRAALGPMLREFIISEAMHALGIPTTRSLAVVTTGESIMRETVLPGAVLTRVAASHLRVGTFQFAASRGSAGDLKALADYTLQRHYPEVETGGNRYLALLREVIKRQATLIAKWQLVGFIHGVMNTDNMALSGETIDYGPCAFMDTYDPATVFSSIDLHGRYAYGNQPPIAAWNLARFAETLLPLLHEDEDEAVKIAEDAISDFSTMFQWNWLAGMRAKLGLFNEEPEDEALIDDLLDMMHKARADYTNTFRALTLEQPQDTLLSGAAEYAEWHERWQKRLDRQEEPKASSHQLMRSSNPAVIPRNHRVEEALEAAVNQGDLSVMERLLGVLSNPYADSPEQAEYAAPPEETACPYRTFCGT
>NZ_CP004078.1|WP_025335007.1|2830328_2831108_-|DeoR/GlpR-transcriptional-regulator
MFQEERISAITDYLNQHQRIDIKEICQQFDVSRDTARRDLLKMEELGLVLRTHGGAVLPPQKNKEVYEYKERLSRESSEKREIGLYAASLVKEGDCILMDASTTVQYAAENITSEHIVVVTNSIDIADVLSRRKTIRTYLLGGELNHQHRFLYGQSTIEKLADYQVDKLFLGACGITSDGLTYPYEEDGVVKREMIKRAKQVIVLADHTKFDDPMFFRIAGLDVIDLLITDRKPSEEMMEKLKEFQVELLTVSEEDNDD
>NZ_CP004078.1|WP_025335006.1|2829520_2830336_-|Cof-type-HAD-IIB-family-hydrolase
MIKLIVSDLDGTLLNHSLRITDSDWDAVKLAFHEGYEFCIASGRMHSEIKLLMQEFHGRYFTVSQNGATIYKKDKELVSDYFFEPEVSSELHQFSSRNPHFVSFIHCTDDSFYTENRSEETLPYESRILTACSDRRDLADALKNGAIKSCKYSFFGEIDKLILLKDELQDQFEGRIESFISASDCLDVMPLNVSKGAGLSFIMQELGLSRNEVACIGDSFNDLSMFALTDHSFAMKGGHSDVKKKAAHVTNSVAEAIEQIINYNRTFEARR
>NZ_CP004078.1|WP_025335005.1|2828187_2829447_+|hypothetical-protein
MASRIEPLIKEYKSDLESVYHTWFLHSSDRLKAFRTIKSGLNDVIQAIESRTFGNDFKGSPLEFVLAAICEQKQVFEGAAHAFYWKPKMRIPDIYENDEHQLAFGRFLKSVSQTTQEKTVLTEIMSLDRLQIKGLGPAVANILYFLHPTLFPPFNTAIVNGFNLLLGRKIKLGSWPAYLEMRAELLSMNEDHRSAFSKDLGAIAGFMFEIGSGRIIMEENAENYLRTEDAKREKTKLKRHLDVSNDIKENNEHSEMQYHLARLGHALGYKVWIAQNDHKRKWDRNVLGELSLPSLPPLNVPKPVADTISFIDVIWLDDRNRIMSAFEVEKSTSIYSGILRLHDLQLSLGSYDSKLCLICPDSREKEVRAQLFRPSLQQESVQRISYILFSDLRSDCDAMCKYGSSSEVLDRISKICGNL
>NZ_CP004078.1|WP_025335004.1|2827050_2827986_-|hypothetical-protein
MKTIRSIIGFVLIVIILSSLGYIGWFASKSGLLSWNNSGTTAAETNAHSQHAAMQQSGTASSAAENPIEELKKKVSSANQSVKQMADLMSDYPYMVPASAATYSNNESGGTGGQAGTGNPVQVQNFKRGIYLLSESVYLVHQLDQMVEAQSALTDSPAPTYQMVVYRYNLLVQSQAALNSVYIKLNQAKDVFLSNVSDAQGADYIGTSDLRQTNKAIYQMAQTVMEMEGLNRWVNQEIEQTVVQAQNLSAAEASNTVSDASQRFSIKGIPMPGLLTTISVLFIVLLTVGVIGMIRSLAVSRPEPANTEDNI
>NZ_CP004078.1|WP_025335003.1|2826453_2827026_-|hypothetical-protein
MMDMDMSGSVQGSVNMGTYGGTGNVISGILSTVTQLLLVALVISLVVAFAVWLKNAYFKESYNKGKQVINNDPLLKTIVVLAATFIGVIIVLYLLGILVNGGFQSNRIGLVSAWSVAGILTFFVKLLTILFVVALIAFLYSYVKQNINRTPAASSSGAVITTGDEIKANRVEENAHNAKAGSDETEKNKD
>NZ_CP004078.1|WP_025335013.1|2837084_2838077_+|3-oxoacyl-ACP-synthase
MAGIRIKDIDIYHPNKRIGNDFFIQHFDEKGIDIRGLLAALGRENRYSIDNEEENSLTMAFEAASNVLEKTGLTGADIDLIAYASQTPEYIFPTNSLMIHRLINGASHTICIDSNANCAGMTAAFEQVSRQMMANPRIRRALVIGSDHVAPHADKNDPVYYANFGDAAAAVILERDENSVGFIDSIYQTDTCVYGNSMFPAEGLSNVGRTGVGAGEFNVKFIPFDDSICVDAASESINTLLSNNEIAPESIKVACFSQLSLPNIKAVSGKTGIDSDAAVYIGDEFGYTSTSSPFIALHRAVTTGLLERGDKLLFWTVGAGWQNVAFVMEY
>NZ_CP004078.1|WP_025335014.1|2838616_2839849_+|NarK/NasA-family-nitrate-transporter
MEAKGFRKAGHSPSLLSAFLYFDVSFMIWVLCGALSLYITKDFGLSDTQKATMVAIPILGGSVFRIPMGILADRIGCKKAGLAGMGLTLIPLLWGWLGGTSLQQIHIIGFMLGFAGASFAVSLSLASRWYPPQYQGLAMGIAGAGNSGTALATFFGPQIAQAYGWHNVFGLAMIPLILVMIVYAILVKDAPNAPAPKPLKNYLSVFKHADTWWFSMFYAITFGGFVGFANYASIFFYDVYGDNAHPGGLTKIQVGYLVTITVIAGSFFRPLGGWIADRIGGMRLLVILYSVISVCAFAIATMPSSFLVMLLYTSVMMACLGMGNGSVFQIIPQRFSSEIGVITGIVGAAGGLGGYLLPKYILGPLKQSTGSQVTGFLVVGSIVLLTTLIFYAVTRSWRKTWAKAESGVNF
>NZ_CP004078.1|WP_025335015.1|2839883_2844095_+|sulfite-reductase-subunit-alpha
MTTTKVKSVCPYCGVGCGIVLEVSGNHVVKLTGDKTHPANFGRLCTKGSTAALAITESGRMEYAYIRQERKAPPVKAGINEAITGTAKRLRAILDEHGPDALSFYVSGQMSLEAQYLINKLAKGFIRTNNIESNSRLCMASAGSGYKLSLGADGPPGSYQDMDNTDLFFVIGANMADCHPILFLRLMDRVKAGAKLIVVDPRRTATAEKAHLFMQIRPGTDLALLNGLLHLLVKNGHTDPDFISEFTSGFEHMPEFLEDYTPDKVAEITGIPESDIRQAAEWIGKAPNWMTCWTMGLNQSTHGTWHTNAICNLHLATGAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVLSEADRRFIEEMWKVPQGTLRSEVGTGTVSMFESMKSGDIKACWIICTNPVATVPNRQNVIAGLEAAELVITQDAFLDTETNRFADILLPGALWAEGEGVMINSERNLTLMRKAVDPPGEALPDWQIIAWVACEMGYSEAFSYASSDEVYREIQQAWNPKTGYDIRGASYDRLRETPVQWPCPPDGASDRNPIRYLSDEAVGTTALKEPADSSAPRILFPTESGKGIFWARPYMPPTELPDGEYPFVLNTGRLQHQWHTLTKTGKVPTLNKLNPGPFIEIHPEDAAMLDIKDQDPVEIRSKRGQAILPALVSDRVRRGNCFSPFHWNDVFGTNLAVNNVTNDSVDSLSLQPEIKYCSVSLGKAAVHPSAGQDKQPNEIETRYQPDAVTVNPKEALYMAQLDTLENVLGLQSPKAVTLDLHEQAYLSGFITSLRAGDSQSASGIPVLPPAAPIEPLKRHWVDGLLAGMFSRSPLQGEQTISSLEAAAAAGPEAAGGLPVTILWASQTGNAEGAAIYCAKKLQESGSNVRLVNMNQYSVPDLAGERFVLFIASTFGAGDPPDNGASFFQSLQADNASRLTKLRYAVLALGDSSYDQFCGFGRNLDTRLAELGAERLMDCMHCDTDYEEQVDTWLDTASVILSEYADGPEGPLSSAGAASVTVQAAGSGTSPLAAEPAGYHRNRPIQSRILFNRRLNKEDSEKETRHYAFDLRNTGLRYEAGDALGVWPTNCPELVAELLRTLNLEPSTPVTVKGQGELPIGKALLHHFEIARIHPEMLRFIRDLSLSERLNELLQSENQTTLKDWLWGRQLIDVLKEFPVSISAAEFTGRLKPLQPRLYSISSSPKANPDEVHITVSTLRYDYMGNPRKGVCSTFLADLATMDTEIPIFIQKNGHFCPPTNPDAPMIMVGPGTGIAPFRGFLQERRATGAKGKNWLIFGEQREDCDFYFRDELEAFMKEGFLHRLDTAFSRDQADKIYVQHRMLEHGAELWAWLQEGAHFYVCGDATQMAKEVDEALRAVIQQHGGMSADEAKHYVHEMSLGKRYQRDVY
>NZ_CP004078.1|WP_025335016.1|2844283_2844871_+|TetR/AcrR-family-transcriptional-regulator
MARSKEFDTTLVLHKAMEVFGHYGYEGTSLQNLLDGLGIARQSLYDTYGTKRDLFVSAVKYYVNDKSAAVISYLERSDSAKQAIADIFHEIVAVLQDEHRRNECFILYSAIDQIPHDPEIAAFFKLDMERLERAFYDALVRAREQGELSERHDDLLGLARYLYHSRYALTQAAKMTGNPQVLDQIAAFTLSALDK
>NZ_CP004078.1|WP_025335017.1|2845160_2846354_-|MFS-transporter
MQTNKSFFTFLIALGVFGIVNTEFGVVGILPQISERFQISASQAGLLVSMFALIIALSGPFMTLLFSGINRKKILSGVLAVFAISNLISAFAPTFTALLLSRLLPAVLHPVYFSVAFAAAASSVPKEQSTNAVAKVFMGLTVGMVLGIPVTSFIGDQFSLEAAFLFSSGINTLALFGIAAFVPSLPVQGKLTYGRQLRILAKPQLWLNVTTACFILAALYSVYSYFAEYLKTVTGMNGETVSFMLVLFGVSGIIGNLQTAKYLSKDMVKTTVFYPIVLVGMYLLIFCLGRYSIPMIAIVLVWGAVFTGGLIISQTWLTSEAREAPEFANSLFVSFANLGVTLGTALGGWFLSHMGTHQITWSGILFLLIAFLCIGLKIKLFDLKEDKDLFVKKSPNQ
>NZ_CP004078.1|WP_025335018.1|2846474_2846894_-|MerR-family-transcriptional-regulator
MNNSLTIRQVAALTGLSVHTLRYYEQIGLLTSIDRNEHGHRCFTSEDVTWIEFINRLKATGMTLTNMLEIAELKRKGDPTLTARRILLEEHYSEVQKALMELQTNLHLLAEKITTYKELENRHALKQKLNEQPTDRSAE
>NZ_CP004078.1|WP_025335019.1|2847125_2847683_-|AAA-family-ATPase
MKFVLIFGPQAVGKMTVGHELEKITDLKLFHNHMTIELLAPYFGFSREMWGLVNKFRQDIFEAAAISDIYGMIFTYVWGFDLQDDWDYVEKICKIFEDKGAEVYFVELEADLEERIERNKTPHRLEHKPTKRDIARSEQDLKRTMEQHRLNSLDGEIKKEKYIRINNTKITAREVAEIIKNRFAL
>NZ_CP004078.1|WP_013308297.1|2847901_2848264_-|cupin-domain-containing-protein
MISKVNVQDKFLQIIDYWNPRIGGELNDSYVKMAKIKGEFIWHHHDHEDEMFFVWKGRLLIRLRDGEIAVNEGEFVIIPKGVEHQPIAEEEVHLLLIEPKTTLNTGNVVNERTVSIPQRI
>NZ_CP004078.1|WP_025335020.1|2848489_2849353_+|LysR-family-transcriptional-regulator
MDIRSLEVFKAVAIEQSITKAAEKLNYVQSNVTARIQRLEQELGVPLLYRYHKKVSLTPAGRELLPHVNKLLYDFEEAIEAVKLSSAPRGTLRIGAMESTASTRLPLIFTQYHKKFPPVELSLYMAPTVDQVSTILKYKVDGAFVDGPILHPEIVEYPVFEESLVLITSYSPEPFQLELILHEPLLSSFAHCIYLGRWQRWLEDNGYAPMKVMEYGTLEGVLKCVENGLGVTVLPISMVESRMQGRLNCHPLPEPYRTVPTVFIRRRDSYMTSALSRFMELVGITNL
>NZ_CP004078.1|WP_025335021.1|2849814_2850645_-|membrane-protein-insertase-YidC
MKKILLLQKWAKPILVMLIGVIPIILLSGCSTASQSNSINADSSGIFNHFFIYPFSILIKFFANAFHGNYGLSIVLMTFIIRLAIMPLMMNQTKKQMDMKEKMAVLQPELTALKEKYKNDVSTDAKKQQQVEMMQLYQKHQFNPLNMGCLPMLLQWPITLAFYYAIRRTPEIAAHDFLWFSLGKTDMILPLIAAAVYYVQFRVSQSVSAQYQQNQNNQMAFIGLLSPIMMGVFSFEMPAALPLYWAVGGIFIIVQTIILNKIYTKPNGESKTYLPM

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Crispr_ID: NZ_CP004078_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP004078_4

3422897-3422984

Orphan

Consensus_repeat	Method
ACAATGGCCGATCCGTTTCAAAAGCGGTA	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NZ_CP004078_4

>merge|NZ_CP004078|4|3422897-3422984|CRISPRCasFinder
ACAATGGCCGATCCGTTTCAAAAGCGGTAAAGCTAAACCGAGTGATTGACCTATGTTGCACAATGGCCAATCCGTTTCAAAAGCGGTA

>NZ_CP004078|4|4|3422897-3422984|CRISPRCasFinder
ACAATGGCCGATCCGTTTCAAAAGCGGTA	AAGCTAAACCGAGTGATTGACCTATGTTGC
ACAATGGCCAATCCGTTTCAAAAGCGGTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP004078.1\|WP_025335546.1\|3427142_3428033_-\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|376824
NZ_CP004078.1\|WP_025335538.1\|3418615_3419149_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_084266661.1\|3419430_3420138_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP004078.1\|WP_025335542.1\|3422005_3422656_-\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|235486
NZ_CP004078.1\|WP_025335552.1\|3433233_3433653_-\|methylglyoxal-synthase	unknown	unknown	gnl\|CDD\|179969
NZ_CP004078.1\|WP_025335540.1\|3420202_3420721_-\|DUF5590-domain-containing-protein	unknown	unknown	gnl\|CDD\|227656
NZ_CP004078.1\|WP_025335543.1\|3423031_3425890_-\|ATP-dependent-DNA-helicase-DinG	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|236148
NZ_CP004078.1\|WP_025335536.1\|3416112_3416985_-\|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|180269
NZ_CP004078.1\|WP_025335549.1\|3430053_3431292_-\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|237339
NZ_CP004078.1\|WP_025335535.1\|3414910_3416116_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP004078.1\|WP_025335547.1\|3428032_3428902_-\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl\|CDD\|376814
NZ_CP004078.1\|WP_025335541.1\|3420717_3422016_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|238623
NZ_CP004078.1\|WP_025335550.1\|3431312_3432467_-\|N-acetyl-alpha-D-glucosaminyl-L-malate-synthase-BshA	unknown	unknown	gnl\|CDD\|274914
NZ_CP004078.1\|WP_025335551.1\|3432532_3433237_-\|bacillithiol-biosynthesis-deacetylase-BshB1	unknown	unknown	gnl\|CDD\|274915
NZ_CP004078.1\|WP_025335545.1\|3426766_3427150_-\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|376751
NZ_CP004078.1\|WP_025335548.1\|3429234_3430026_-\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|223417
NZ_CP004078.1\|WP_025335534.1\|3413411_3414707_-\|asparagine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235176
NZ_CP004078.1\|WP_025335537.1\|3417120_3418623_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|273520
NZ_CP004078.1\|WP_025335533.1\|3412655_3413393_-\|DnaD-domain-protein	unknown	unknown	gnl\|CDD\|226445
NZ_CP004078.1\|WP_025335544.1\|3426006_3426648_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809

Protein	Function_ID	Function_description	E-value
NZ_CP004078.1\|WP_025335546.1\|3427142_3428033_-\|pantoate--beta-alanine-ligase	gnl\|CDD\|376824	pfam02569, Pantoate_ligase, Pantoate-beta-alanine ligase. Pantoate-beta-alanine ligase, also know as pantothenate synthase, (EC:6.3.2.1) catalyzes the formation of pantothenate from pantoate and alanine.	2.20248e-155
NZ_CP004078.1\|WP_025335550.1\|3431312_3432467_-\|N-acetyl-alpha-D-glucosaminyl-L-malate-synthase-BshA	gnl\|CDD\|274914	TIGR03999, thiol_BshA, N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA. Members of this protein family are BshA, a glycosyltransferase required for bacillithiol biosynthesis. This enzyme combines UDP-GlcNAc and L-malate to form N-acetyl-alpha-D-glucosaminyl L-malate synthase. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	0
NZ_CP004078.1\|WP_084266661.1\|3419430_3420138_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.20058e-11
NZ_CP004078.1\|WP_025335542.1\|3422005_3422656_-\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|235486	PRK05472, PRK05472, redox-sensing transcriptional repressor Rex; Provisional.	1.12545e-111
NZ_CP004078.1\|WP_025335552.1\|3433233_3433653_-\|methylglyoxal-synthase	gnl\|CDD\|179969	PRK05234, mgsA, methylglyoxal synthase; Validated.	2.62273e-77
NZ_CP004078.1\|WP_025335540.1\|3420202_3420721_-\|DUF5590-domain-containing-protein	gnl\|CDD\|227656	COG5353, COG5353, Uncharacterized protein conserved in bacteria [Function unknown].	4.07559e-14
NZ_CP004078.1\|WP_025335543.1\|3423031_3425890_-\|ATP-dependent-DNA-helicase-DinG	gnl\|CDD\|236148	PRK08074, PRK08074, bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated.	0
NZ_CP004078.1\|WP_025335536.1\|3416112_3416985_-\|NAD(P)-binding-domain-containing-protein	gnl\|CDD\|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	4.92788e-108
NZ_CP004078.1\|WP_025335549.1\|3430053_3431292_-\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|237339	PRK13299, PRK13299, tRNA CCA-pyrophosphorylase; Provisional.	1.4305e-119
NZ_CP004078.1\|WP_025335535.1\|3414910_3416116_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP004078.1\|WP_025335547.1\|3428032_3428902_-\|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl\|CDD\|376814	pfam02548, Pantoate_transf, Ketopantoate hydroxymethyltransferase. Ketopantoate hydroxymethyltransferase (EC:2.1.2.11) is the first enzyme in the pantothenate biosynthesis pathway.	1.04823e-160
NZ_CP004078.1\|WP_025335541.1\|3420717_3422016_-\|amidohydrolase	gnl\|CDD\|238623	cd01298, ATZ_TRZ_like, TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are catalyzed by atrazine chlorohydrolase (AtzA), hydroxyatrazine ethylaminohydrolase (AtzB), and N-isopropylammelide N-isopropylaminohydrolase (AtzC). All three enzymes belong to the superfamily of metal dependent hydrolases. AtzA and AtzB, beside other related enzymes are represented in this CD.	0
NZ_CP004078.1\|WP_025335551.1\|3432532_3433237_-\|bacillithiol-biosynthesis-deacetylase-BshB1	gnl\|CDD\|274915	TIGR04001, thiol_BshB1, bacillithiol biosynthesis deacetylase BshB1. Members of this protein family are BshB1 (YpjG), an enzyme of bacillithiol biosynthesis; either BshB1 or BshB2 (YojG) must be present, and often both are present. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	6.66201e-99
NZ_CP004078.1\|WP_025335545.1\|3426766_3427150_-\|aspartate-1-decarboxylase	gnl\|CDD\|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	9.00038e-85
NZ_CP004078.1\|WP_025335548.1\|3429234_3430026_-\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|223417	COG0340, BirA, Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism].	2.15802e-84
NZ_CP004078.1\|WP_025335534.1\|3413411_3414707_-\|asparagine--tRNA-ligase	gnl\|CDD\|235176	PRK03932, asnC, asparaginyl-tRNA synthetase; Validated.	0
NZ_CP004078.1\|WP_025335537.1\|3417120_3418623_-\|AAA-family-ATPase	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	6.45993e-144
NZ_CP004078.1\|WP_025335533.1\|3412655_3413393_-\|DnaD-domain-protein	gnl\|CDD\|226445	COG3935, DnaD, Putative primosome component and related proteins [DNA replication, recombination, and repair].	8.48271e-36
NZ_CP004078.1\|WP_025335544.1\|3426006_3426648_-\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	7.1252e-06

>NZ_CP004078.1|WP_025335542.1|3422005_3422656_-|redox-sensing-transcriptional-repressor-Rex
MKSDKISEAVVRRLPVYLRFLNELHRREIATVSSQELGQRLDLNPAQIRKDLAYFGDFGRKGIGYDVPYLIEKIRHILKLDQPINVALVGAGNLGHALSNYNIYLKDTMKITAVFDSYPPKVGTKINTLTVQPMEELAQTVRDQGIRIGIITVPDQEAQNVADILIESGIEAILNFAPVILKTPSEVRVHAADFTTDLQSLAYYLHEGKEEEADGQ
>NZ_CP004078.1|WP_025335541.1|3420717_3422016_-|amidohydrolase
MGNKWIIRGGKFAVPGSDKPVIDGYMVIDNDLITYIGEEPPVLEEDIPSFDGSRLLFLPGLVNTHGHAAMSLLRGYGDDLALQVWLQEKMWPMEGKFTGDDVYWGTALSVLEMLKGGTTTFLDMYDHMGRVAEVTEASGIRAVLMRGVIGLCPPEVQDQKLAEAVAFAKEWHGKANGRITAMMSPHSPYTCPPDYIEKFVQAAHDLDLPIHTHMSETRREVEQNVTDYGLRPVAHLEKLGVFTRPSLVAHGVHLTDEEIEILARHQVGVAHNPGSNLKLASGVARVPELLKAGVTVSLGTDGPASNNNLDMFEEMRLAALIHKGVSGDPTAVPAAEALLMGTEYGAKSVFLNQVGRLAPGMKADFIAIDIDQPHLLPHTDLISHSVYSASAKDVEHVWVDGKQVVQHGKCLTLDEEEIRRKAQEAFEDLLKR
>NZ_CP004078.1|WP_025335540.1|3420202_3420721_-|DUF5590-domain-containing-protein
MRKRRKWGLYGAFLALLLLFGFYQFFAYVLKDTWSERKEAEAIATSRAALTEIDRTQKSIWDENAIYWVLTGKNKAGTDMMVWVRFTTDGKPVQGDSAVHAEELSQGTSEKRMRKIIASSLPGIQIKRLLPGAYNGEYAWQLFYKEGDRYYYRFYRFSDGEQIGDGYSLPNR
>NZ_CP004078.1|WP_084266661.1|3419430_3420138_+|alpha/beta-hydrolase
MAVIAARLSQRFGVVESFQTRLSIHELILELKKDIEDFGSGPVSLVGYSWGAWLSFIFAASFPDLVRKLILVGSAPFEQQYAKDLRATRLARLNEQDRQRIHELEAVLQKPKSNQNELLRQYGKLIEKADVFNPLPSDDDDVEIDLNIFQHIWKEASELRSSGELLKLGYQIVCPVTAIHGIHDPHPYAGVIQPLSAVLKDFRYHLLEHCGHTPWKERIAKDHFYDLLFAELSEK
>NZ_CP004078.1|WP_025335538.1|3418615_3419149_-|hypothetical-protein
MKIRLIPTLLTALLSAALLFGGWFLYRQFAVQEPLEKIVSSYKGVNASHISINRNAVTLKLDLQPGTKLRELVQYINNEGESLIGSRTVNLDVVQHSNQTLDEYWDKAMFSVAEAMESRKYTIIPEKLKELSTQYKNVTATTEIDGNNVYVSLTDGKESKFIILPREPEKMGVWNNA
>NZ_CP004078.1|WP_025335537.1|3417120_3418623_-|AAA-family-ATPase
MPKWTKEVLIGFVPVLLIFLAFLGLNVVPIIVAAAMVGALLTITHLRGGIAVGASTEKKRKKNGPAKLTFEEIGGQDNAKQELREALDFLIRHEEISKFGIRPLKGILLTGPPGTGKTLMAKAAAHYTNSVFVAASGSEFVEMYVGVGAGRIRDLFKDARTRAAKENKESAIIFIDEIDVIGGKREGGQQREYDQTLNQLLTEMDGIYNSDTPRILLIAATNRKEMLDPALLRPGRFDRHIQVDMPDKKGRKSILELHAKNKPLHPDTDLDKIAEEAYGFSGAQLESVMNEAAIYMMRDNLTQVEHRHLAMAIDKVMMGEKTDRETNQEEKKRVAIHELGHAIMAEGLRPGSVSQVTLTPRGQALGYVRHNPQQEQYLYTKEYLEEQIMIALGGAAAEEIYYGGRSTGSRGDFDQALGIVEMMMKSGLTSLGIAKLEMVTTEELMKENSKILDELMERTRTLLENKRNVFDFSLDILMKEEVLSGEQFRCQFRDSVLLPA
>NZ_CP004078.1|WP_025335536.1|3416112_3416985_-|NAD(P)-binding-domain-containing-protein
MNFKKIGVIGGGTMGQGIAEMLAAKGLDVLLVEKTPEKLDYSYNMIETSLDKQLEKWAITQAEKKLILGRIQKVTHFAELSACDMVIETIIEDLEEKKKVFNQLDQVCPNNIILASNTSTLSLTELASSTMYPERVIGMHFIYPVAKVDIVEIVRGLKTSDSTFEHTKAFVDDVVEKKGVMIYESPGFVTSRLICLFINEAMHVLQEGVASPEDIDDAMRIGYQFQYGPLEMADRFGLDSVLAALERMFREFGELKYRPSTILKKMVRAGQLGMKSGEGFFKYDKDGDRI
>NZ_CP004078.1|WP_025335535.1|3414910_3416116_-|acetate-kinase
MKVLVINAGSSSLKYQLYDMTDESVLAKGLVERIGMDSSILTHKPTGKQEVTEVSEILEHTTAIRKVLANLTDKEHGVIDSISEINAVGHRVVHGGETFKASALVDGAAKSEIRRLFDLAPLHNPAAVMGITASEVNMPGVPQVVVFDTAFHQTMPEKAYMYAIPRVLYNKYKVRRYGAHGTSHDFVSKAAAEYLGRPLEDLKIITCHIGNGASVTAVKGGVSVDTSMGMTPLEGLMMGTRSGDIDPAVVPYVMNKEELTPGEASSMLNKHSGLLAISGTSSDMRDIIDGYEKGEPNSTLAFEMYEYRLRKYIGSYAAAMDGVDVIVFTAGVGENASLLREKVLSNLTFLGIELDKEANKVRSGDPRRISASGSKVEVLVVPTNEELVIARDTLRIVQEQA
>NZ_CP004078.1|WP_025335534.1|3413411_3414707_-|asparagine--tRNA-ligase
MANKTVIKGVKDHVGESVVIGCWVNNKRSSGKIQFLQLRDGTGYIQGVVVKSEVEEEVWDAAKSLTQESSLYVTGVIREEPRSQSGYEMTVTGIEVLHLTENYPITPKEHGVDFLMDHRHLWLRSSKQRAILVIRAEIIRAIQEYFDINDFTLVDPPILTPTSAEGTTNLFHTKYFDEDAYLTQSGQLYMEAAAMALGRVYSFGPTFRAEKSKTRRHLIEFWMIEPEMAFTEHEESLRVQEEFITHVVQSVLKNCRTELEAIGRDISKLENIKAPFPRITYDDAIKFLNDHGFDIPWGEDFGAPHETAIAEEYDKPVFITNYPAGIKAFYMKPDPNRPEVVLCADMIAPEGYGEIIGGSQRIDDPALLEERFKEHELSLDTYKWYMDLRTYGSVPHSGFGLGLERTVAWICGLDHVRETIPFPRMLYRLYP
>NZ_CP004078.1|WP_025335533.1|3412655_3413393_-|DnaD-domain-protein
MDGKEKTSWSEGLSFGLQSGMAVIPYALLTAYRKLDLTGSETMLLIHLLSFRQVEGKDFPSLEELQAVTGRSASVIAGELQKLIKEGFLNIEAGSDDGKGLHYERYDFSGLYDKLGSYLFSQRSSAAPKAGSPSFQSDTRSSGAEKGGKMPSGIVPAEEDRPSLFVVFEKEFGRPLSPMECETISGWLDQDRYPEELILLALKESVFAGKVYFRYIDRILLEWSRNRVKNAQDVKAYSQRFRGGS
>NZ_CP004078.1|WP_025335543.1|3423031_3425890_-|ATP-dependent-DNA-helicase-DinG
MKFAVLDFETTGTQSVGEIIQVGLAIIEEDRSISRVYGSYVKPGGPIPPFITGLTGITDNDVQDAPELEEMMMELVPLLNDVVLVGHNVAFDFHFLQNALDRCGYLPFQGRILDTIDFLKICFPSLTSYQLGAVSSHFGIVHERPHQADSDALATAHVLLKCLDELYSLPLLTAQRLTELFAGEDSDMSWFFDGLLGEREMESFQPESELQFYRQLALAAGDWTDLPPPREDGDNPAEQLSFEDYMEEVLKRLRSILPQYESRQAQEIMFAEVIQALEQEKHLLIEAGTGTGKSLGYLLPAIYQSVRTGQKVMVSTHTINLQDQLRERDIPLLTETVPFPFKAAVFKGRGHYLCLRKFEHKINKKDFVSPREDTLTAAQMIVWLTQTESGDDEELNMSSRGGDFWETVASDTDSCLGRACPWFRKCYYHRAKHEAGNADVVITNHSKLFADVKAGHQLLPAYEYLVIDEAHQLEEVAGKHLGMNMKHFTVSHTLNRLYKDSRNGQLPALRQILQSSGSEQASEWSGVIDRVYPDLLTVKESWDLLSEKLFTLIPERADTAAGEAGQLVHRLLPAKKPKGWEELASLENTLNLSLSDAIRKGEKMLSEMRDQDGQSSADSLVTDIGGLFKDLAEIREQVHFFMGMNNENVVYWLEANGNYRSKSLQLYAVPVDVSAQLKELFFDKKKSIVLTSATLSVDKSFQYMIDNLGLNEAQEEGRLSTIQLPSPFRYRDQALLVIPRDFPSVKGTVGDARFVDMLVQSLAEAAVTTKGRMLVLFTSYKMLRQVFDPLKEALASEEITVLGQGVEGGSRSKLLRRFQDNSASVLLGTSSFWEGVDIPGDALTCLAIVRLPFQPPNHPLAEAKAELLQAQKKNPFMKLSVPQAVIRFKQGFGRLVRTAQDRGIVIVYDTRVIESYYGKYFLYSLPGPKMEHMTTEQMVPRIAEWLQHDGAS
>NZ_CP004078.1|WP_025335544.1|3426006_3426648_-|hypothetical-protein
MFQQMFAEMNVMLSDIAKQWPGAQGIRRQELLSKYRMLRKLSDEALDEWLAFAEALSMFRQHTDLSEETETEPAGSEAPGIEMENFARGQGYYKLLMYPKCIEQFSTVILHYPDNLAARLYLAMSHLHLGKAGEAWEHLEHMLPLVQSRKLKAHLYNAMGCIAAAGRRFGEAKELFNLALKYDPSFQEPGLNLEICRRGRGELQIGSELASLL
>NZ_CP004078.1|WP_025335545.1|3426766_3427150_-|aspartate-1-decarboxylase
MFRHMMKSKIHRATVTEANLNYVGSITIDEDLMEAADLLENEKVQIVDNNNGSRLETYVIPGPRGSGVICLNGAAARLVQPGDTVIIISYAMLSHEELGHHKPTVVFVDENNRPVKLDNKELHATIA
>NZ_CP004078.1|WP_025335546.1|3427142_3428033_-|pantoate--beta-alanine-ligase
MRVVRTVEQLREAVGFMRGAGQGPVGLVPTMGYLHDGHASLLRRAGEMCGTVVMSIFVNPIQFGPNEDFEAYPRDERRDLELAEREGADIVFIPAVEEMYPREIRSKIVVSSLTTRLCGASRPGHFDGVTTVVAKLFNMVQPDYAYFGLKDAQQVAVLRQMVDDLNMNVKIVPCPIVREADGLALSSRNVYLSAEERLQALVLSRSLREAHSAVEEGRAATTDEVRELLKSTISSSPLADIDYAEILTFPQLEPLEGNFPLVETDGEIIMALAVRFGRTRLIDNMIFTPKEVAALV
>NZ_CP004078.1|WP_025335547.1|3428032_3428902_-|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MAEKQALNIVKMKKMKAEGVPLSMLTAYDYPSARLAEEAGVDMILVGDSLGNVVLGYDSTLPVTIDDMVYHTRAVARGAEHTFIVADLPFMTYHGSIDESLRNVRRLMQEGHAHAVKMEGGLEICGTVSTIVSAGVPVLGHIGLTPQSVNTIGGYRVQGKDARDAQRLMDEAKALEKAGAFGIVLELVTEEVAEAITRELSIPTIGIGAGRYCDGQVLVYHDVLKYASPYREKRFVKTYADVGGIIREALGEYVKDVKQRAFPAANHAFGADEGVLESLYGAAGKGARS
>NZ_CP004078.1|WP_025335548.1|3429234_3430026_-|biotin--[acetyl-CoA-carboxylase]-ligase
MSTKKMRAAEADGLRDPDWAGRLHRMDTVVSTQEEAKRLAESGAPEGTAVMAEEQTGGRGRMGRKWHSPKGKGIWMSVVLRPSIPLQSTPQLTLLAGVAVCTAIRKITGVEAGIKWPNDLLAGGRKVCGILIESNVGPGGLQYAIAGIGISANLSEEDYPAELKEIATSLLIEGGVPVDRVKLAEEVLRELKTHYELYLEQGFGPIARLWEEQSVTLGRRIGRRTQQGWLEGTAIGLGEDGELLLRDDNGMVTSVCSGEIVLI
>NZ_CP004078.1|WP_025335549.1|3430053_3431292_-|CCA-tRNA-nucleotidyltransferase
MNWKMADPLMAEAAGRIMVRLTEAGHEAYWVGGCIRDELLGRPVNDMDITTSARPESVMSLFPKCVPTGLQHGTVTVLEAGFPFEVTTYRTESGYADHRRPETVVFVKDVKEDLRRRDFTINAICMGLDGALIDPFGGAEDLRGRLIRCVGTAEERFDEDALRMLRCVRFASTLDFRVAKNTWRGLLRRRDGLAHIAVERVFAELTRIVEGPRPFSGLGMLARSGLLARGKAPFPWTGEQLAAAAASLAPIGELESALLRWALLLHALGTPAGEAEGVLRAWTFPGATRRGVAQVLRFREAWTAAAEAGPEDGPADFRRRFLAAVLAFGADAAEGWLTLLAALPGGGPGAGLVPMARRWLRKMPVRGLADLAVTGGDLAAALNKRPGPWLGQLLQQLLLAAAAGDGPTTGRP
>NZ_CP004078.1|WP_025335550.1|3431312_3432467_-|N-acetyl-alpha-D-glucosaminyl-L-malate-synthase-BshA
MDRLLKIGITCYPSLGGSGVVATELGKLLAEKGHEVHFITHSIPFRLGTFQKNIFYHEVEVNDYYVFRYPPYDLALATKMAQVAKMEKLDLLHVHYAVPHAVCAFLAKQMVGGDGVKVVTTLHGTDITVLGQDESLRDLIRLGINESDAVTAVSQDLINETRRVLDISREIDLTYNFVDKRVYYPRDVSDLRGDFASPDEKILMHISNFRPVKRVGDVVDIFDKVAKKIPSRLLLVGEGPELPKIQAKIAEMGLEDKVRFLGKQDEIAQVISLADVLLLPSEKESFGLVALEAMACGVPTIGSQAGGIPELVLHGETGFLAPIGDTAAMAEYAVRLLTDEALARNIRKACLERAREDFCNDAITDQYESIYYRVLDRKTANTVC
>NZ_CP004078.1|WP_025335551.1|3432532_3433237_-|bacillithiol-biosynthesis-deacetylase-BshB1
MKLDILVFGAHADDAEIGMAGTIAKHTAAGLKVGLCDLTAAEMSSNGTPKIRKEEAARAASALGVSSRTNLGLPDRGLRLTEDQIWAVTAEIRRSSPDIVFAPYWEDRHPDHVACGTLVEEAVFNAKLRRYMPALKAVPAPQLYFYFINDLGRTDLVVDVSETYQAKESALSAYRSQFQKTPGEDVVATPLNDGYIERVRSRDMLLGQRRGFSLAEGFATKVPYAVDWFKRKKQ
>NZ_CP004078.1|WP_025335552.1|3433233_3433653_-|methylglyoxal-synthase
MKIAFIAHDRKKDEMVNFVTAYEHVFQGHEMYSTGTTGQRIMEATQLKINRFMSGPLGGDQQIGALVAQDELDLIIFLRDPLMAQPHEPDISALLRLCDVYGIPVATNIATAEILVKAIDRGDFAWRDLVHKYKPGVDE

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Crispr_ID: NZ_CP004078_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP004078_5

3816772-3816886

Orphan

Consensus_repeat	Method
GCGGCGGGCTCCTTCTACTCCGTGCGAGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP004078_5

>merge|NZ_CP004078|5|3816772-3816886|CRISPRCasFinder
GCGGCGGGCTCCTTCTACTCCGTGCGAGCAATCGCTCGCGGCTTCGCCGCAACGCTTACGCTTGCGCGAATACGAGCGCGTTCCCGCGGCGGGGTCCTTCTACTCCGTGCGAGCA

>NZ_CP004078|5|5|3816772-3816886|CRISPRCasFinder
GCGGCGGGCTCCTTCTACTCCGTGCGAGCA	ATCGCTCGCGGCTTCGCCGCAACGCTTACGCTTGCGCGAATACGAGCGCGTTCCC
GCGGCGGGGTCCTTCTACTCCGTGCGAGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP004078.1\|WP_025335918.1\|3820892_3821864_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224616
NZ_CP004078.1\|WP_025335914.1\|3817092_3817512_-\|cytidine-deaminase	unknown	unknown	gnl\|CDD\|180142
NZ_CP004078.1\|WP_084266555.1\|3815323_3815467_-\|YqzL-family-protein	unknown	unknown	gnl\|CDD\|379412
NZ_CP004078.1\|WP_025335906.1\|3806437_3807262_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_193373903.1\|3808524_3810360_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NZ_CP004078.1\|WP_025335913.1\|3815571_3816465_-\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NZ_CP004078.1\|WP_144240532.1\|3814235_3814484_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025335907.1\|3807353_3808484_-\|RNA-polymerase-sigma-factor-RpoD	unknown	unknown	gnl\|CDD\|236413
NZ_CP004078.1\|WP_025335922.1\|3824231_3825230_-\|flotillin-like-protein-FloA	unknown	unknown	gnl\|CDD\|237462
NZ_CP004078.1\|WP_025335909.1\|3810384_3810864_-\|YaiI/YqxD-family-protein	unknown	unknown	gnl\|CDD\|178882
NZ_CP004078.1\|WP_025335921.1\|3823603_3824200_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025335923.1\|3825293_3826679_-\|nodulation-protein-NfeD	unknown	unknown	gnl\|CDD\|223961
NZ_CP004078.1\|WP_025335917.1\|3818616_3820878_-\|HDIG-domain-containing-protein	unknown	unknown	gnl\|CDD\|224397
NZ_CP004078.1\|WP_025335910.1\|3811080_3813156_-\|glycine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234925
NZ_CP004078.1\|WP_025335911.1\|3813148_3814036_-\|glycine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|236473
NZ_CP004078.1\|WP_025335916.1\|3818125_3818620_-\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|376735
NZ_CP004078.1\|WP_025335915.1\|3817730_3818126_-\|diacylglycerol-kinase-family-protein	unknown	unknown	gnl\|CDD\|260134
NZ_CP004078.1\|WP_025335912.1\|3814531_3815287_-\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|273175
NZ_CP004078.1\|WP_025335919.1\|3821870_3823061_-\|sporulation-protein-YqfD	unknown	unknown	gnl\|CDD\|377731
NZ_CP004078.1\|WP_025335920.1\|3823057_3823351_-\|sporulation-protein-YqfC	unknown	unknown	gnl\|CDD\|131903

Protein	Function_ID	Function_description	E-value
NZ_CP004078.1\|WP_025335918.1\|3820892_3821864_-\|PhoH-family-protein	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	1.79011e-142
NZ_CP004078.1\|WP_025335914.1\|3817092_3817512_-\|cytidine-deaminase	gnl\|CDD\|180142	PRK05578, PRK05578, cytidine deaminase; Validated.	7.43016e-61
NZ_CP004078.1\|WP_084266555.1\|3815323_3815467_-\|YqzL-family-protein	gnl\|CDD\|379412	pfam14006, YqzL, YqzL-like protein. The YqzL-like protein family includes the B. subtilis YqzL protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.	2.27475e-08
NZ_CP004078.1\|WP_025335911.1\|3813148_3814036_-\|glycine--tRNA-ligase-subunit-alpha	gnl\|CDD\|236473	PRK09348, glyQ, glycyl-tRNA synthetase subunit alpha; Validated.	0
NZ_CP004078.1\|WP_193373903.1\|3808524_3810360_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_CP004078.1\|WP_025335913.1\|3815571_3816465_-\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	0
NZ_CP004078.1\|WP_025335907.1\|3807353_3808484_-\|RNA-polymerase-sigma-factor-RpoD	gnl\|CDD\|236413	PRK09210, PRK09210, RNA polymerase sigma factor RpoD; Validated.	0
NZ_CP004078.1\|WP_025335922.1\|3824231_3825230_-\|flotillin-like-protein-FloA	gnl\|CDD\|237462	PRK13665, PRK13665, hypothetical protein; Provisional.	0
NZ_CP004078.1\|WP_025335915.1\|3817730_3818126_-\|diacylglycerol-kinase-family-protein	gnl\|CDD\|260134	cd14265, UDPK_IM_like, Integral membrane undecaprenol kinase and similar enzymes. This mostly bacterial family of homo-trimeric integral membrane enzymes, the products of the dgkA gene, catalyzes the ATP-dependent phosphorylation of undecaprenol to undecaprenyl phosphate. C55-isoprenyl (undecaprenyl) pyroposphate acts as a scaffold for the assembly of peptidoglycan components; undecaprenol kinase (UDPK) is involved in recycling undecaprenyl units for re-use in the peptidoglycan biosynthesis. UDPK does not participate in the de-novo biosynthesis of undecaprenyl phosphate. Gram-positive bacteria have a large pool of free undecaprenol, in contrast to gram-negative bacteria. UDPK may also play a role in a stress-induced pathway that affects the function of ribosomes. In Streptococcus mutans, UDPK has been shown to be required for biofilm formation, such as in the case of smooth surface dental caries. Members of the UDPK family have low activity as diacylglycerol kinases (DAGK), and many of them are annotated as DAGKs.	5.57854e-46
NZ_CP004078.1\|WP_025335923.1\|3825293_3826679_-\|nodulation-protein-NfeD	gnl\|CDD\|223961	COG1030, NfeD, Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones].	2.75209e-77
NZ_CP004078.1\|WP_025335917.1\|3818616_3820878_-\|HDIG-domain-containing-protein	gnl\|CDD\|224397	COG1480, COG1480, Predicted membrane-associated HD superfamily hydrolase [General function prediction only].	0
NZ_CP004078.1\|WP_025335910.1\|3811080_3813156_-\|glycine--tRNA-ligase-subunit-beta	gnl\|CDD\|234925	PRK01233, glyS, glycyl-tRNA synthetase subunit beta; Validated.	0
NZ_CP004078.1\|WP_025335909.1\|3810384_3810864_-\|YaiI/YqxD-family-protein	gnl\|CDD\|178882	PRK00124, PRK00124, YaiI/YqxD family protein.	2.09971e-49
NZ_CP004078.1\|WP_025335916.1\|3818125_3818620_-\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|376735	pfam02130, UPF0054, Uncharacterized protein family UPF0054.	1.83349e-55
NZ_CP004078.1\|WP_025335912.1\|3814531_3815287_-\|DNA-repair-protein-RecO	gnl\|CDD\|273175	TIGR00613, DNA_repair_protein_RecO, DNA repair protein RecO. All proteins in this family for which functions are known are DNA binding proteins that are involved in the initiation of recombination or recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	1.40657e-79
NZ_CP004078.1\|WP_025335919.1\|3821870_3823061_-\|sporulation-protein-YqfD	gnl\|CDD\|377731	pfam06898, YqfD, Putative stage IV sporulation protein YqfD. This family consists of several putative bacterial stage IV sporulation (SpoIV) proteins. YqfD of Bacillus subtilis is known to be essential for efficient sporulation although its exact function is unknown.	3.08474e-132
NZ_CP004078.1\|WP_025335920.1\|3823057_3823351_-\|sporulation-protein-YqfC	gnl\|CDD\|131903	TIGR02856, Uncharacterized_protein_YqfC, sporulation protein YqfC. This small protein, designated YqfC in Bacillus subtilis, is both restricted to and universal in sporulating species of the Firmcutes, such as Bacillus subtilis and Clostridium perfringens. It is part of the sigma(E)-controlled regulon, and its mutation leads to a sporulation defect. [Cellular processes, Sporulation and germination].	3.36353e-20

>NZ_CP004078.1|WP_025335913.1|3815571_3816465_-|GTPase-Era
MSYKSGFVAIIGRPNVGKSTLMNQVIGQKIAIMSDKPQTTRNKIHGVYTTNDSQIVFLDTPGIHKRQSKLGDYMNQTAMSTLGEVEAVLFLIDAAEGLGGGDRFIAEQLQGVKTPVILVMNKIDKLEPEALLPLITEYSKLHDFAEIVPISAKVGSNVNTLLDQLQKYLPEGPQYYPDDQVTDHPEQFVIAELIREKILHLTREEVPHSIAVAIEDMRAEPNGVVHISAVIFVERDSQKGIIIGKQGAMLKEVGRRARTDIENLLGSKTFLELWVKVKKDWRNQERVLRDLGFHKDQ
>NZ_CP004078.1|WP_084266555.1|3815323_3815467_-|YqzL-family-protein
MRDFSWKYFAMTGDVDAYLLYREAGESMVTADDTAAEEEQVYDEEAN
>NZ_CP004078.1|WP_025335912.1|3814531_3815287_-|DNA-repair-protein-RecO
MLHRVEGIVIRSMDYGEGNAIITLCTENAGKVGVLVRGAKKVKSRHAALIQPFTVGQYVFFRNNNGLGTLNSGEIINSHYPIREDLIKAAYGSYACELLDRVLHDEETGSFWFRQLSACLDALEEGKEPGIIINVFEMKILQAAGYGPQLDSCVACGREKPDDEMRLSPRLGGILCRSCRHNDPPAMEVSPRALKLLRLFAALDLTRLGNVDVRESTRAELKSIMRAFMDTQLGLRLKSQNFLDQLDKYNI
>NZ_CP004078.1|WP_144240532.1|3814235_3814484_-|hypothetical-protein
MMSCLKANDEKAAAGRTGTHVERESNERLLGIASRGRWEPGAAALMKRHPGVRRRQREKWISQISGSSREGRNQVGWNRGSI
>NZ_CP004078.1|WP_025335911.1|3813148_3814036_-|glycine--tRNA-ligase-subunit-alpha
MNFQQMILTLNEFWSNQNCIIVQPYDTEKGAGTMNPMTFLRSLGPEPWKVAYVEPSRRPSDGRYGENPNRLYQHHQYQVIIKPSPDNIQEIYLDSLQALGIDPLQHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGIETSPVSVEITYGMERLASYIQEKENVFELEWVDGLTYGDVFHQPEVEHSTYTFEVSDVSMLFGLFNTYEAEARRAMDRHLVFPAYDYVLKCSHTFNLLDARGAISVTERTGFITRVRNLARQVAATYVEEREKLGFPLLKKEGVQLG
>NZ_CP004078.1|WP_025335910.1|3811080_3813156_-|glycine--tRNA-ligase-subunit-beta
MAKDLLFEIGLEEIPARFIRAAMEQLQDRMTKWLDASRLEHGEVKSYATPRRLAVLVKGVAEKQADVSEEVKGPSRKIALDAAGEWSKAALGFARSQGVSPEQFTFKEVGGVEYIYATKSSEGVDTYSLLAEGLTGIVSAMTFPKNMRWGAYDFKFVRPIRWLVALYGSDIVDFEITGVRTGNVSRGHRFLGQEAVIAQASDYVEGLRSQHVIADVEEREALILEQINKLAADKNWTIAIKEDLLEEVLFLVETPTVLFGTFDPAYLNIPQEVLITSMREHQRYFPVLDAEGKLLPYFVTVRNGNAEHLETIAKGNEKVLRARLSDAKFFYEEDQKLKIEDALAKLETIVYHEELGSVADKVRRIRQIADSLAAKLQTAREVSAKVSRAADICKFDLVTLMVYEFPELQGTMGEDYARKAGEDELVAKAIFEHYQPRFAGDAIPSTEPGAIVSIADKIDTIVGCFSIGIIPTGSQDPYALRRQTAGIVQIVLERKLPVGLNDIFEIAVQVHENTRNLKLSVDELRTNLYEFFGLRVKRLLSDNVRYDVVDAVMAAGYDDIVAVVARSRALADAVDSKDNFKNTVESFNRVSNLAAKATGAALDSALLNEAAESALHETWQSLRTPYQKALEADDAGQALTLLAGLSDAITAFFDSVMVMAEDEQVRANRLALLAGIDADLKSFADFGKLVW
>NZ_CP004078.1|WP_025335909.1|3810384_3810864_-|YaiI/YqxD-family-protein
MNSTDARGRTIVVDADACPVKKETADIARVSGVPVMMVSSYAHELRGGEGVDVIHVDNSDQSADLYIANHVKSGDIVLTGDYGLAALVLAKGCHVLSFRGQTYDETNMDMMLEGRHARAKERRRGHHTKGPKPFTAEDRNFFQHKLTKLLNLLQENVQL
>NZ_CP004078.1|WP_193373903.1|3808524_3810360_-|DNA-primase
MKVVVVASGHGNIPEEVIESVLAKHDIVDTVGKVVHLTKRGKYLWGLCPFHSESTPSFTVTPDRGVFHCFGCGMGGNAIKFRMEIEGLSFPEAVKIMAEESDIPMPEGAGGIQSAHNPEIDRLLQAYEWSAKFYHYLLKNTEHGKAAMDYLRSRKFSDKMIDQFQIGFAPDRWDTLLQFLERRQFDLAEMERGGLLSARSEGKGYIDRFRGRIIFPIANRAGKVVAFAGRILGEGQPKYLNSPESKLFNKSRILYNLHQSKASIRKTRQLVLFEGYGDVISAWESGVHNGVATMGTSLTENHASMIKALADEVVIAYDGDRAGQAAALKALSMLEAVDLRVKVAVIPGGMDPDEFVSQYGGERFREQIIESAVSTVKFKLIYLKKNHILLEEDGKIAYVKEALPIIASLHSSTEREVYLKEIAAELELSYESLKQDCNLLRASMQKNIPEGDNNDKRWNNGRHKKGQVQARALLPAYHAAERSLLSLMFQDSDAAAYVNEHLGEDFNIDDHAAIAAYLYAYYAQGKPPDISRFLSSLQDDRLEKIAASISMMESPPDWSPQVLDDYIREVRKYPVQRMMDKKREEMIEAEKAGDFLRAAQIASEIIALDRQ
>NZ_CP004078.1|WP_025335907.1|3807353_3808484_-|RNA-polymerase-sigma-factor-RpoD
MANDQHTELETEFTLDQVKDQLIESGKKRSSLNIKDIMEKLSPFDQDPEQMDEFYEQLSDLGIEVVNDNDEEVTLRPNDESESGDGDDFSFDDDLSLPPGIKINDPVRMYLKEIGRVPLLSADDEVELAMRIKNGDEEAKRRLAEANLRLVVSIAKRYVGRGMLFLDLIQEGNMGLIKAVEKFDHNKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRVSRQLLQELGREPAPEEIAAEMELSVEKVREIMKIAQEPVSLETPIGEEDDSHLGDFIEDQEALAPADAAAYELLKEQLEDVLDTLTEREENVLRLRFGLDDGRTRTLEEVGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE
>NZ_CP004078.1|WP_025335906.1|3806437_3807262_-|hypothetical-protein
MNVEKRDIILKEIQYWRRTKLLTEQYCDFLTNLYSDEGAVPNRNPITLQNLQQGNIKIWMFAFGIISLILLIGFYFSVFPWGLQLATAVSLLVVCYGYAGLLRNRMPVIGLSLAGIGSFLTLGFGLWMIFLHNLEDGLSIPIFVGVCGLLWIILGFTLRIGLLHFGGYGALCLLYAGFAGRVRPEAGVWELQLLWLPLCVLMIWLSWLLYHRVKGVSGVYFGVGTLLWLMPEIDSLLLRRDYPAWLSLLLIGKIAAELTLLFLFRKKWIAWVAT
>NZ_CP004078.1|WP_025335914.1|3817092_3817512_-|cytidine-deaminase
MDSITLLQEAIKARAKAYIPYSRFGVGAALLDQDGHVHHGCNIENAAYSVTNCAERTALFSAMAQGHKRGTFKALAVVGDTELPITPCGACRQVIVELCEPDMKIILGNMKGDIRETTVRELLPGAFGPDELKQGQAPE
>NZ_CP004078.1|WP_025335915.1|3817730_3818126_-|diacylglycerol-kinase-family-protein
MPKNTAAGPKRFWKSFWYAAQGIRQAFRSEQNMRVHTGFAVLVLLLAALFRVPPGDWMLLLLAITLVLAAELINTAIESVVDLVSPELHPLAKAAKDTAAGAVFLTAAFAVISGIYVFYRPVMDWIAGFMS
>NZ_CP004078.1|WP_025335916.1|3818125_3818620_-|rRNA-maturation-RNase-YbeY
MSLELVWNNEQEEMEIDDRLISLLEDILQKAGIQEGVDSGEVDLTFVDNKRIHELNREYRGIDRPTDVLSFALNESGEDEPEIVYEVDEDEQGGIPDMLGDIIISVTRAKEQAEEYGHSLERELGFLFVHGFLHLLGYDHQDEASEAEMMGKQEQVLSQVGLTR
>NZ_CP004078.1|WP_025335917.1|3818616_3820878_-|HDIG-domain-containing-protein
MASKQPSKFSGFSYNVSGWKYSAVTRYALFLLLGILVYFSLSPDLLPKRYDIKEGTNSAKEIVAPMQILDKKATLKAQEQAAENVQPKYQIIPLRSENLVTSLLDRIDRLNQDDTISQSDKTSIYREEIPQRVNDFILNFVLSSRGSGAYSDNLLNEMQKVIRQQAYSIPEETYIKIPRLTSQDIIEMKPVARDIVSRLMNDQISDANAARAKVAEQVSISSLSQRTAREVVQELARAAITANKFYDEDATKEAEVQARENTPPVYIEQGEVLVAKGQRITPELYQLLDENGLLRSNVNYWPQLGLLMLAGILSVGLLMFIRQSGASGSSGFKYNNSQLLMLVIVFLITIISLRLAAFLQTDTRPFMGFLAPVAIGAMLVALLLDITLAYFCSILFAALASIILNVQQNTIFDFNFGFFALVVSFVAVFATHRAGQRTTLLKGGIMVCLFGSLTVFMLHLLGGGDWQQIHTLYAIGFAFAGGLLTVVLVIGLMPFFESTFGILSALKLVELSNPNHPLLRKLLTETPGTYHHSVMVGNLSEAAAEAIGADGLLCRVGSYYHDIGKTKRPFYFIENQNNMENPHDSIEPKLSKSIIVAHARDGVEMLKEYKLPKPIRDIAEQHHGTTFLHYFYHKALRQAEEKGIEPDFTEDDFRYPGPKAQSKESAVIGIADSVEAAVRSLRSPTVNQVETMIEKIIKSRLDDHQFDECDLTLKELDIIARTLKETVMGIFHSRIEYPEEAKKPKKEEGAVNA
>NZ_CP004078.1|WP_025335918.1|3820892_3821864_-|PhoH-family-protein
MSDKTASISISLQNAGEALALFGPQDGFLKLIEREIPARIDSREAELTVHGGEREVDMLAQLFQSLLSLVRNGYILSERDVQYAVELAKDFRADQLLDLFKGEITTTFRGKPIRVKTIGQKHYVTTIKKRDIVFGIGPAGTGKTYLAVVLAVAALKEGSVKRIILTRPAVEAGESLGFLPGDLQEKVDPYLRPLYDALYDVMGPDQVAKALERGLIEIAPLAYMRGRTLDDSFIILDEAQNTTPEQMKMFLTRLGFGSKMVITGDVTQIDLPRGKKSGLIEANTILSSVEEIGFVYFAEQDVVRHSLVQKIIVAYERSAENLE
>NZ_CP004078.1|WP_025335919.1|3821870_3823061_-|sporulation-protein-YqfD
MKEPPLSWLRGAVELHITGDRTEGFINAVTEAGIVIWNVKATGKGVSLRLLLDDFYALRPLLKQTGCRMHITGRIGLPFVAARLWKRKFFATGLLLFGIVLVMLSSLVWTVRVEGNDRLASEDVLDAARKEGIYPYQWIWRMDSPDKLSKHLAARLPGVSWIGIERNGTFVKIQIVEAKLPEAKPLNSPRHLISRTDAVITDIYAEQGRPVVQRNARVKKGEILISGIIGDEANMQAVVAKGEVKGLVWHEYNIEVPLEKKHTAYTGERKDSTYLVLGSWAVQLWGYGKSSFTASRTLTELDPLTWRGTRLPFGWMTEKEMEVKETRETVTPEAAKKEGLARAAADIAARYGSDSVIKSQKILHEKKENGKVYMKVLFEVEERITEELPIVYNRGE
>NZ_CP004078.1|WP_025335920.1|3823057_3823351_-|sporulation-protein-YqfC
MTRIGRSLRGWTNGMLDLPQDLLSDMPRITLIGNKEMVIENHKGVLNFSPGQLTIKLAKGSLEIAGEGLVITSILGRELAVEGVIGEIRYKESGEKR
>NZ_CP004078.1|WP_025335921.1|3823603_3824200_-|hypothetical-protein
MSWIYVIAVIIFALVSQFNKTSKNKNRKGPRGAMPPFGSGPGEGPLRRQGSGLPDRGGKAESQGSGFPVPVPSAQQAERTDEGREPGMAPAFPEPALFPTPDYETGEGASLEQPEEEDGVEVRQERMRRELERIHRALDRISGDMDSGGIGQDSSARSASAASASKLPSLDGDPRSGLVWAEILGPPRSRRSMNSRRP
>NZ_CP004078.1|WP_025335922.1|3824231_3825230_-|flotillin-like-protein-FloA
MEASLITVLLIAVVVIIVLSVFLSFFPVMLWISALASGVRISIITLVAMRLRRVTPSRIVNPLIKATKAGLGLNINQLESHYLAGGNVDRVVNALIAAQRADIPLEFTRAAAIDLAGRDVLQAVQMSVNPRVIETPTVAAVARDGIEVKVKARVTVRANIDRLVGGAGEETIIARVGEGIVTTVGSSNSHKDVLENPDSISRTVLQKGLDAGTAFEILSIDIADVDVGKNIGAYLQTEQAEADKRIAQAKAEERRAMAVAQEQEMKARVVEMKALVVESESKVPLAMAEALRAGQIGVMDYMNLKNIEADTQMRGSIGKMGDQDNDGSKSGK
>NZ_CP004078.1|WP_025335923.1|3825293_3826679_-|nodulation-protein-NfeD
MEGKTVTGLRKITLTVCALFLLLFVPLGAALAAGSPGSPPAGSGPQKGPVFILPVDQAIERGLESFLKRGFEEAGKYGASLIVLEIDTPGGRVDSAEQIGSMVRESKIPTLAFIKGDAASAGSYIALNAKKIVMKPGSMIGSASLVDSNGKKVDDAKLVSFWKSKMAGAAALNGRDPDIAAGMTDINLVVDKPELGVNKSKGEIIALTSEGALKAGYSDATRNTPEEAAAWLGYSTDDVFRVQHTGAEKLSQFLTHPAVMTILLFIGIAGVVIELLVPGFGVPGIVGTLAFVLYFFGNYVAGFAGAETWLLFIVGLVLMVLELFVPSFGILGVLGSVSLIAGVVRAAYSFTHALFSLGIAFAAALVVIICFVIAFKERGIWNRFILSDSLSKEAGFIPASEKPELLGQRGISITPLRPSGTALIAEQRLDVVTEGGFIGVNTPVIVVKVEGGRIVVKETQE

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Crispr_ID: NZ_CP004078_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP004078_6

3995921-3996029

Orphan

Consensus_repeat	Method
CAATCCGCAATCCGTACCTTGAAAACAGCTAATCGGCAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP004078_6

>merge|NZ_CP004078|6|3995921-3996029|CRISPRCasFinder
CAATCCGCAATCCGTACCTTGAAAACAGCTAATCGGCAATGGGGAATCAGGAATCGGCGATCCAATCCCCAATTCGCAATCCGTACCTTGAAAACAGCTAATCGGCAAT

>NZ_CP004078|6|6|3995921-3996029|CRISPRCasFinder
CAATCCGCAATCCGTACCTTGAAAACAGCTAATCGGCAAT	GGGGAATCAGGAATCGGCGATCCAATCCC
CAATTCGCAATCCGTACCTTGAAAACAGCTAATCGGCAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP004078.1\|WP_025336045.1\|3987075_3987930_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP004078.1\|WP_025336053.1\|3997129_3998527_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226657
NZ_CP004078.1\|WP_051529881.1\|4001563_4002445_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP004078.1\|WP_025336051.1\|3992634_3995358_-\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582
NZ_CP004078.1\|WP_025336043.1\|3984722_3985505_-\|(S)-acetoin-forming-diacetyl-reductase	unknown	unknown	gnl\|CDD\|181518
NZ_CP004078.1\|WP_025336052.1\|3996297_3996978_-\|DUF559-domain-containing-protein	unknown	unknown	gnl\|CDD\|225408
NZ_CP004078.1\|WP_144240536.1\|3983284_3984634_-\|SPOR-domain-containing-protein	unknown	unknown	gnl\|CDD\|335993
NZ_CP004078.1\|WP_025336050.1\|3991252_3992629_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl\|CDD\|223362
NZ_CP004078.1\|WP_025336044.1\|3985804_3986965_-\|epoxide-hydrolase	unknown	unknown	gnl\|CDD\|377658
NZ_CP004078.1\|WP_025336060.1\|4005017_4006004_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381302
NZ_CP004078.1\|WP_025336056.1\|4000667_4001153_+\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NZ_CP004078.1\|WP_025336058.1\|4002504_4003806_-\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NZ_CP004078.1\|WP_025336059.1\|4003940_4004942_-\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450
NZ_CP004078.1\|WP_025336041.1\|3982907_3983153_-\|DUF4321-domain-containing-protein	unknown	unknown	gnl\|CDD\|379506
NZ_CP004078.1\|WP_025336061.1\|4006233_4007223_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275263
NZ_CP004078.1\|WP_025336048.1\|3988512_3989694_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP004078.1\|WP_025336055.1\|3999089_4000427_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|274346
NZ_CP004078.1\|WP_025336049.1\|3989859_3991245_-\|UDP-N-acetylmuramate--L-alanine-ligase	unknown	unknown	gnl\|CDD\|234757
NZ_CP004078.1\|WP_025336054.1\|3998543_3998939_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224639
NZ_CP004078.1\|WP_025336040.1\|3982156_3982876_-\|Maf-family-protein	unknown	unknown	gnl\|CDD\|376812

Protein	Function_ID	Function_description	E-value
NZ_CP004078.1\|WP_025336045.1\|3987075_3987930_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	4.67755e-20
NZ_CP004078.1\|WP_025336053.1\|3997129_3998527_-\|hypothetical-protein	gnl\|CDD\|226657	COG4194, COG4194, Predicted membrane protein [General function prediction only].	7.85594e-12
NZ_CP004078.1\|WP_051529881.1\|4001563_4002445_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.78719e-77
NZ_CP004078.1\|WP_025336051.1\|3992634_3995358_-\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
NZ_CP004078.1\|WP_025336043.1\|3984722_3985505_-\|(S)-acetoin-forming-diacetyl-reductase	gnl\|CDD\|181518	PRK08643, PRK08643, (S)-acetoin forming diacetyl reductase.	1.25288e-136
NZ_CP004078.1\|WP_025336052.1\|3996297_3996978_-\|DUF559-domain-containing-protein	gnl\|CDD\|225408	COG2852, COG2852, Very-short-patch-repair endonuclease [Replication, recombination, and repair].	0.00014577
NZ_CP004078.1\|WP_144240536.1\|3983284_3984634_-\|SPOR-domain-containing-protein	gnl\|CDD\|335993	pfam05036, SPOR, Sporulation related domain. This 70 residue domain is composed of two 35 residue repeats found in proteins involved in sporulation and cell division such as FtsN, DedD, and CwlM. This domain is involved in binding peptidoglycan. Two tandem repeats fold into a pseudo-2-fold symmetric single-domain structure containing numerous contacts between the repeats. FtsN is an essential cell division protein with a simple bitopic topology, a short N-terminal cytoplasmic segment fused to a large carboxy periplasmic domain through a single transmembrane domain. These repeats lay at the periplasmic C-terminus. FtsN localizes to the septum ring complex.	0.00158386
NZ_CP004078.1\|WP_025336050.1\|3991252_3992629_-\|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl\|CDD\|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	8.32888e-147
NZ_CP004078.1\|WP_025336044.1\|3985804_3986965_-\|epoxide-hydrolase	gnl\|CDD\|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	9.86997e-54
NZ_CP004078.1\|WP_025336060.1\|4005017_4006004_-\|aldo/keto-reductase	gnl\|CDD\|381302	cd19076, AKR_AKR13A_13D, AKR13A and AKR13D families of aldo-keto reductase (AKR). Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.	0
NZ_CP004078.1\|WP_025336056.1\|4000667_4001153_+\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	1.97584e-63
NZ_CP004078.1\|WP_025336058.1\|4002504_4003806_-\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NZ_CP004078.1\|WP_025336059.1\|4003940_4004942_-\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NZ_CP004078.1\|WP_025336041.1\|3982907_3983153_-\|DUF4321-domain-containing-protein	gnl\|CDD\|379506	pfam14209, DUF4321, Domain of unknown function (DUF4321). This family of proteins is functionally uncharacterized. It is found in bacteria, and is approximately 50 amino acids in length.	6.88576e-06
NZ_CP004078.1\|WP_025336061.1\|4006233_4007223_-\|radical-SAM-protein	gnl\|CDD\|275263	TIGR04470, hypothetical_protein_ALIPUT_00462, radical SAM mobile pair protein B. Members of this family are the downstream member (B) of a pair of tandem-encoded radical SAM enzymes. Most of these radical SAM gene pairs have an additional upstream regulatory gene in the MarR family. Examples of high sequence identity (over 96 percent) from cassettes in several Treponema species of the oral cavity to those in multiple Firmicutes in the gut microbiome suggest recent lateral gene transfer, as might be expected for antibiotic resistance genes. The function is unknown.	4.89218e-32
NZ_CP004078.1\|WP_025336048.1\|3988512_3989694_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.82503e-53
NZ_CP004078.1\|WP_025336055.1\|3999089_4000427_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|274346	TIGR02907, Stage_VI_sporulation_protein_D, stage VI sporulation protein D. SpoVID, the stage VI sporulation protein D, is restricted to endospore-forming members of the bacteria, all of which are found among the Firmicutes. It is widely distributed but not quite universal in this group. Between well-conserved N-terminal and C-terminal domains is a poorly conserved, low-complexity region of variable length, rich enough in glutamic acid to cause spurious BLAST search results unless a filter is used. The seed alignment for this model was trimmed, in effect, by choosing member sequences in which these regions are relatively short. SpoVID is involved in spore coat assembly by the mother cell compartment late in the process of sporulation. [Cellular processes, Sporulation and germination].	5.58527e-09
NZ_CP004078.1\|WP_025336049.1\|3989859_3991245_-\|UDP-N-acetylmuramate--L-alanine-ligase	gnl\|CDD\|234757	PRK00421, murC, UDP-N-acetylmuramate--L-alanine ligase; Provisional.	0
NZ_CP004078.1\|WP_025336054.1\|3998543_3998939_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	1.13299e-25
NZ_CP004078.1\|WP_025336040.1\|3982156_3982876_-\|Maf-family-protein	gnl\|CDD\|376812	pfam02545, Maf, Maf-like protein. Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and archaea.	1.96605e-83

>NZ_CP004078.1|WP_025336051.1|3992634_3995358_-|valine--tRNA-ligase
MAEQDQLTPAQQPELEGNGGSPAEGAAKNDMPTTYDPKAAEQKWYPYWAEGGYFKAGQRPDAKPYTIVIPPPNVTGMLHIGHALDFTLQDILIRTKRMQGYDTLWLPGTDHAGIATQTKVEQKLRAQNISRYDLGREKFLEQVWAWKDQYAATIHEQWAKMGLSLDYSRERFTLDEGLSKAVREVFVKLYEKGLIYRGKRIINWDPAARTALSDIEVEYKEVNGHLYHLRYPLKDGSGFITVATTRPETMLGDTAVAVHPEDERYKDMIGKTLILPIIGREIPVIADEYVEKEFGSGAVKITPAHDPNDFEVGQRHNLPQIVVMDESGTMNAEAGPYKGQDRSECRKNIVADLKEQGVLISIEDHVHQVGHSERSGAVVEPYLSTQWFVAMQPLAEAAIKAQKDGSGVNFVPDRFEKIYLHWIENVRDWCISRQLWWGHRIPAWYSESTGEMVVARDEEEARRISGLSDLKQDEDVLDTWFSSGLWPFSTLGWPDDSADMQRYYPTDVLVTGYDIIYFWVARMIFTALEFTGEKPFSDVLIHGLVRDAEGRKMSKSLGNGVDPLEVIEKYGADAMRFMISTGSTPGQDLRFRWEKVEQARNFANKIWNASRFALMNLEGVSFEDIDISGKLGTADRWILHRLNETSRDISRLINAYDFGETGRLLYNFIWDDLCDWYIEFAKLSLYGSDTEAKSSTQSVLAYVLDRTLRLIHPFMPYISEEIWQHLPHEGETITLAAWPQYDAALENPDAVAEMNLLMDMIRAVRNIRAEVNVPMSKKVELIVKAGSEETLAIIERNNAYISRFANTSSFEAGLNPEAPEKVMSAVITGAELLLPLSGLIDIEQEIARLEKEVQTLNSEVERVEKKLGNPGFVAKAPAKVIEEERAKQADYSAKREKVLARIAELRG
>NZ_CP004078.1|WP_025336050.1|3991252_3992629_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MEEMNGAGSAAPLQSYTAAVDWINGLIPFGIRPGLERIERLMERLGHPHRRLKFIHVAGTNGKGSTCAFLTSVLRQCGYSVGTFTSPYITKFTNRFQYNGEDIPEETLTAIANRLHPLVEEIAETPLGSPTMFEVTTALAILYYAEECYPDVVVWETGLGGRMDVTNIVTPIVSVITNVGYDHTDVLGDTLEKIAYEKAGIIKPGVPVVSSVSQPEAVSVLKDKAASCKSTLYLAGEQFTYESKGTWEGVQTFAFKGPFRSLDIGIAMKGEHQLANAAGAMMALEVLRQYMAFILEDEDVLAGFRHTFWAGRLEEIPGSPRIVLDGAHNPEGAQSLASSLPKFYQYRKLNLMMGMLSNKHHESYFKHILPIVDTLILTEPDFRKKMDAEHLQLIAESLRENYAKDHLQIIVEHDWGKALQLLKSMTEEDDLAVVSGTLYLIADVRSALLRQPDSEKGW
>NZ_CP004078.1|WP_025336049.1|3989859_3991245_-|UDP-N-acetylmuramate--L-alanine-ligase
MDTTERVHFIGIGGYGMSAIARVMLEMGYTVTGSDVAAQELTEKLIAKGAKVYIGHTAEQVKGADLVVYSTALSKDNVERVEAERLNIPILHRSQMLGRLLNERKGVAVAGAHGKTTTSSMIALVMEECGVDPTYIIGGEIMNVGTNAKAGQGEFVVAEADESDGSFLQYHPWLAIVTNIEADHLENYGGDFERLKSAYVQFMSQLREDGTAIVCADDETVTSLLPKIKANVTTYGIRSAADYTATDIALGDRQVTFTMNHGATALGRVELSVPGLHNVYNAMATIIACLKAGIPFAAIASAIVKFNGAKRRFQVLGEADDILVIDDYAHHPTEIQATISAAKATGKRIIAVFQPQRYTRTFFLLDAFSRAFGEADEVIITDIYSPAGEKQIEGVSSAKLVELIIQNSNPGARHLPTKEDVLADLKDRLAPGDLVITMGAGDIYKVGYVLADNLRKRGASK
>NZ_CP004078.1|WP_025336048.1|3988512_3989694_-|diguanylate-cyclase
MDFQLDIRTMLITLILGNMFMVLLIFAYRFRSPYDQANSSFAVSKWLQAAGWLLVLIRDNLPGPHLILLSNALILGGVGLEIIALLMMAGEFRAGARRYYVIITTLSVLSFGLIYFFHNSDNLRIASASLSAVLFVGFPAYRFTTSKEGSPLQTVMGLVYSVLASILLARAFSALFSERDMNIFSPGLAQHLYYIGMFLIMILGTVGFVLLSRERSYDELKRMANVDELTGILNRRAFIVQAQLAAAAAAERREPISFLLIDIDHFKRVNDNYGHVAGDSALRNFAATVELLLGPRDLFGRYGGEEFAILLLGAGEEESDRKAEQLRQAVMNSRIEGHNLQYTISIGVITVIPDNKPQLDLLYKLSDAALYKAKDEGRNRVVRSRPPEGLVRR
>NZ_CP004078.1|WP_025336045.1|3987075_3987930_+|helix-turn-helix-transcriptional-regulator
MPQWDRHKKRIVNIEFVAVEELKLLPYPERSTLVFITSGSIKGMLNQRPITISAPGILCLTEDDQMQVMEKNYVSAQSFSFHAEFLNTIRLTETEAHFPAAPRIQTGLSLFERGCTHHGVPRISEKAYPLLFEWFFIMGTEVQAQSDDLWVCRIKKYLIQIMGLLEELNQSREHSPVEAVLDYIHTNYARKISLKDLTACAHLNRMTLNKLFQERCGKTAIGYLQSHRLKVASELLTHTDMSLSDIAQATGFEYDTYLIKQFNAKKGMSPTMYRRSSRQFAVIQ
>NZ_CP004078.1|WP_025336044.1|3985804_3986965_-|epoxide-hydrolase
MTVERFRIHVSDNILDDLKERLHRVRWPDQLEGSGWERGTDLYELQSLVSYWRDQYDWRAQEAELNRFSQYRCTIDGIDVHFVHERGKGPNPIPIILTHGWPDSYLRYHKIISLLTDPESHGGRPEDAFDVIVPSLPGFGFSGRPTQPGFNNLTVSEMWVKLMTSVLGYSRFVAAGGDIGSGVTRNLAANHPELLYGIHLTDVGIIRDLLSAHNEDALTEEERQYKISASRWIAQEGGYMSLQSTKPQTLAYGLSDSPAGLAGWILEKFRAWSDCKGNLLQKFSEDDLLTAIMIYWVTNTIGSSTRIYYENSHTLPPLGRIEVPAGIAIFPADIALPPKSWIMRNLNVTRWSEMPSGGHFTAMEEPERMADDIRAFCRPFRAENNQ
>NZ_CP004078.1|WP_025336043.1|3984722_3985505_-|(S)-acetoin-forming-diacetyl-reductase
MSRVDGKVALVTGGGQGIGRAIALRLSQDGFAVAVVDLNENNANKVAGEIEAAGGRSIALKADVSNRDEVFAAVEETAAKLGGFDVIVNNAGIAPVKMIEEVTLDDLDKVFHINVASVVWGIQAATAKLKELGHGGKIVNASSQAGHVGNASLSVYSASKFAVRSLTQTAAQELAKYGITVNAYCPGIVQTPMWGSIDKQITSSKGEEQGEATKEFGSKITLGRLSTPEDVAAFVSFLAGPDSDYMTGQSPLIDGGMVFK
>NZ_CP004078.1|WP_144240536.1|3983284_3984634_-|SPOR-domain-containing-protein
MSNGRMTFRFDAGKDKLKELQPESVPEQTKTEQQAEIYSLDEARRMAGSSRQGIAPDPMHPRGHFQDREYRLEELEQAYYDNKKTFGGSPNRNDRNVRDDRDDGNLDGRGSDSTVDSELLRESFLRSRRIGDWREGQTGTEGSYADFDYGSPAYSEDDGPSARGPFPELEEEPLNDGGGYYTTRRPSSWWKFPASVAGAIGIGLMLGYAALTFIGGVNSGDSANKASSNSAAGQHTSGNAVNAPAIPVQVAAQSYYLLQYGVFSTPEGAAQAKQELLNAGLAAGIDPEDGNRVYAGLSSDREQAKLLGGKLEAQGIDLYVKEVTLPGESRLVFNGDGETVAQYFEASRALLGELSSLSAALLGGGPAADMTKVSDLHLQWTEAAKALEAGLTPNERGVAKELEKSVSRGVSAMSEYGKSKADGLLWEVQSSMLEMLSGQKRLMAAMEQG
>NZ_CP004078.1|WP_025336041.1|3982907_3983153_-|DUF4321-domain-containing-protein
MKKKNVGTLLLFLILGWLAGSWIARLLQPVKALSFLTKSTLIKWSPQADLDIISYDITIRLKLCLLSLAGIIIAVWLYRRK
>NZ_CP004078.1|WP_025336040.1|3982156_3982876_-|Maf-family-protein
MNDNSIPSIILASGSPRRRELLSLLGLPLEVIPSEADESFPPEWAPERIVSELALRKAEAVIPLAGKRDAVIVGSDTIVVLDGRVLGKPANEKESREMLSALQGRSHKVYTGLACIRLWEREVNAALRLEELGTRGGETIKLGDLGQFSILSESPAGTPAVMAGYTESRVTFRPMSGEEIGGYIRTGEPLDKAGSYGIQGIGSVFIEKIEGDFYSVMGLPLNLLYQMLLRYSISPFNIG
>NZ_CP004078.1|WP_025336052.1|3996297_3996978_-|DUF559-domain-containing-protein
MNVEEAHAAFIQLHLRSRTGERKGRLERGHREAEKLFCCNVWWPLLGDFNHLHPEYEVLDWRGLSYFCDFAWITPFARLIIEIKGFGPHVTDMDRKKYCNELNREAFLTAMGFQVISFAYDDVAHHPERTITLLRMVLSRFQPQSSPDNLHSVAEREIVRLACMLARPLRPIDVEAHLGINHRTAVRMLQTLCGKGWFNAVTGATGKHVVRYELQRGAVNQLMQKT
>NZ_CP004078.1|WP_025336053.1|3997129_3998527_-|hypothetical-protein
MTFVLILLPVCLIFLLVVQLSYGTRPNITGGVIIFGIGIPEYASQAEELKSLRASFHRSNTFFIIIGALAILPLFALSRYFSLVYMYWWIWMGIVLWAGYRLFSKYHRAAARIKRAHEWSIGERHVVRADTTLIFLKKKMSISPIWFIAPFLIALAVMFYAWRSSSEFGIVMGAQATGMTLLFFLLSLAFRRMRTKVYSDDSTINEGLNRAQRRYWSMLFLAIAMLDAVFAAAATLSGLDTLAHFGAVWHTLIAIQAVAPLAVAWYTDRKMNEWSRRLVEAGGQPFYTDDDEYWINGITYHNPNDRSMLVPKRAGLGLTLNMAMRGSKVLIGVIFTLVFMFIAGLGIFLVREDWMVPRLMVGTDGIVHVQSPSYGYSFSLDQIRELRLENELPEGMRTNGVATDTYARGHFRLKGWGNTRAYIFKHSPPYIVIRLAEEYIVYNDRNANDTRQTFEEIRGKLPITH
>NZ_CP004078.1|WP_025336054.1|3998543_3998939_-|GntR-family-transcriptional-regulator
MIITLDFKSETPIYVQLRNAVVVAIGRGDLQDGEKLPTIRQLAEELGINAMTVNKAFTTLKNEGFITIDRRHGATVTKPEGGNAEYKEKLEQELTLVISEASLKGVGRKEFLDTCADIFAALAAGQRPIAE
>NZ_CP004078.1|WP_025336055.1|3999089_4000427_-|LysM-peptidoglycan-binding-domain-containing-protein
MFDQSHGLRFDIYERIHLSQDLPGISELEEVELLPDIQVIQREDRAELRGQLLLTGLYRSEDDRTHRLDHAIPVEITVPLARVSSLEEIGVEIENFDIDLLTMRSVNITGVLSLRGIGGSEPVPAWQSEEFTVAYSPEEGDRAIAGKSDAPADVAEGLYENSLWTYGEGSAEDAALEREQIEALGADQAFPGITQEEDSDELPNLNLEEDRYAEIHSENGQPFIAKQETEPSGQWKSPASWSHFAQGGANAGGSSLAGDRKSASKTEDITDTDDEESTDLADASAPVSFDSLAATGSGPAEEQPAPEADSLPETPLSPEEKPDLKIALGSKKDTGQQTKEHLSFSSLLSSGKNRSENEEAAAEKTVSSTAAVTPSESSDDSEWKSRFMRTKDGEQAFRKVRLCIVQREETLDSIAEKYQLSARELVLYNRLSGQTVEEGQVIYIP
>NZ_CP004078.1|WP_025336056.1|4000667_4001153_+|transcription-elongation-factor-GreA
MANKEDEIILTPEGYAQLDEELKELKTVKRKELAERLKVAISYGDLKENSEYHSAKDDQAFMETRIKQLENMMKYARVVSADSLDVTSVSVGSLVVLNDIEFSEKVEYRIVSPAEADVDQNKISYESPLGKELLGKKSGSVIKVDAPAGVIEYELLEIRLA
>NZ_CP004078.1|WP_051529881.1|4001563_4002445_-|RluA-family-pseudouridine-synthase
MPGRSVTSAEDKGEAIDRWLKETVRMPDKLLARLRREDGIQWRGDRLRLALFPPREPGIEPVWQELEVLHEDDFCLVVHKPAGMAVHPDGSGSGVTLDHAVAAHYAASGENCAVRHIHRLDKDTTGPVLYAKNEFAQAILDGAMREKTISRRYAAIVQGEVAKSLTVIDQPIGRDRHHAGRRRVSPGGQPAVTRIVGREVWQGASLLHIELETGRTHQIRVHLSHLGHPLYGDGLYGGPKAPEAEGARPLLRQALHGEALRFAHPWTGEELDIADPWPDDMLGLRHVLGGSSS
>NZ_CP004078.1|WP_025336058.1|4002504_4003806_-|glutamate-1-semialdehyde-2,1-aminomutase
MGKESLARREEASRAAFEEAKNYIPGGVNSPVRAFKSVGLTPIYVERGEGSRIYDIDGNSFIDYVCSWGPLIMGHAHPEVVKVLQETAVRGTSFGAPTLIETEMAKTVVERVESVDIVRMVNSGTEATMSAIRLARGYTGRSKIVKFEGSYHGHGDSLLIKAGSGVATLGLPDSPGVPEGIAANTIAVPYNDLESVKLAFERFGNDIAAIIVEPIAGNMGVVPPAPGFLEGLRKVTTGYGALLIFDEVMTGFRVNRGCAQGLFGIKPDLTCFGKVIGGGLPVGAYGGSREIMEQIAPSGPIYQAGTLSGNPLAMAAGLTTLKLLTPEVYDRLETLGARLETGLKVNAEEAGVPLTVNRVGSMVCPFFTEGPVTNYDTAKASDVNRFRAYFGQMLEQGISVPPSQFEGMFISAAHSEQDIDDTIEAHRAALKLL
>NZ_CP004078.1|WP_025336059.1|4003940_4004942_-|porphobilinogen-synthase
MSFPITRHRRLRSSAGIRGMVRETVLNPLDLIQPIFVTYGNGIKNEIGSMPGVYHFSLDTLKEEVDEIVSLGIPAVLLFGIPETKDAVGSSGFDEYGIVQEATRLIKQWYPELLVIADTCLCEFTDHGHCGMVHTHTVDGVVHGDVLNDASLELLTRTAVSQAKAGADIIAPSNMMDGFVQAIRAGLDEAGFQHVPIMSYSVKYASAFYGPFREAADSAPQFGDRKTYQMDPANVREAIREAESDVLEGADMLMVKPALAYMDVIRVIREQFDLPLVAYNVSGEYSMVKAAARQGWINEKAIVLELLTGLKRAGADTIITYHAKDAVRWLRGE
>NZ_CP004078.1|WP_025336060.1|4005017_4006004_-|aldo/keto-reductase
MKKRELGKSGLEVSALGLGCMGMSEFYGSLDEEESIRTIHRAIELGGTFLDTADMYGVGRNEELVGRAIKGQRNNVILATKFGNVRAADGTPLGINGRPEYVKQACDASLRRLGVDHIDLYYQHRVDPNTPIEETVGAMADLVQAGKVRYLGLSEASPRTIDKAHAVHPIAALQTEYSLWSREVEDEILPFCREKGIGFVAYSPLGRGFLTGQIKSFDDLEENDYRRFAPRFQGDNFRKNLDLVDRIHEIAKEKSCSSSQLALAWLLSQGDDIVPIPGTKRRSYLEENIGALDITLDEDDLRRIEEAAPQGAAAGFRYPEASMKTIDR
>NZ_CP004078.1|WP_025336061.1|4006233_4007223_-|radical-SAM-protein
MPKTYEPVTTKTGMTRVKEERMPFGWSVNPYRGCAHGCSFCYARGFQGFIDKKADDEFQNHIMLKTNAAEALEEQLSRLARRHRHDLEAMRKELGEVVIGTATDPYQPVEGRTELTRKCLMVLAKYGIRTSVTTRSPLILRDQDLLEQMRSLTVNISINTLNDRLARRLEPGSPLPSKRLDTLQKLAERGIATSVFIAPILPLLTDDLEGLEALFAASAQRGAESVMTSLLRLSPDVKGWYFRTLQEQFPDVLERYRRMYADGSYAEAVYRENMSRLLDELHRKYASRFRAAPEWSLPRGANGAGEEPGRPGLAEIAGEPPVEQLSFPF

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Crispr_ID: NZ_CP004078_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP004078_7

4788911-4788985

Orphan

Consensus_repeat	Method
ATAAACCGGAGGTTTTCCCGTTTA	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP004078_7

>merge|NZ_CP004078|7|4788911-4788985|CRISPRCasFinder
ATAAACCGGAGGTTTTCCCGTTTATTGAGCGAATCATCTATTTCCCCAAAAATAAACCGGAGGTTTTCCCGTTCA

>NZ_CP004078|7|7|4788911-4788985|CRISPRCasFinder
ATAAACCGGAGGTTTTCCCGTTTA	TTGAGCGAATCATCTATTTCCCCAAAA
ATAAACCGGAGGTTTTCCCGTTCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP004078.1\|WP_025336755.1\|4802343_4803228_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP004078.1\|WP_025336744.1\|4787720_4788362_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025336750.1\|4794377_4795328_-\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP004078.1\|WP_025336743.1\|4786349_4787573_+\|AGE-family-epimerase/isomerase	unknown	unknown	gnl\|CDD\|225493
NZ_CP004078.1\|WP_025336737.1\|4776218_4776428_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025336735.1\|4773023_4774943_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377924
NZ_CP004078.1\|WP_025336741.1\|4784272_4785052_+\|flagellar-motor-protein	unknown	unknown	gnl\|CDD\|181654
NZ_CP004078.1\|WP_025336742.1\|4785048_4785924_+\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|235887
NZ_CP004078.1\|WP_025336740.1\|4782098_4784090_-\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NZ_CP004078.1\|WP_025336749.1\|4792791_4794252_+\|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPB	unknown	unknown	gnl\|CDD\|235292
NZ_CP004078.1\|WP_025336738.1\|4776901_4778536_+\|ferredoxin--nitrite-reductase	unknown	unknown	gnl\|CDD\|236572
NZ_CP004078.1\|WP_025336751.1\|4795502_4795988_+\|DinB-family-protein	unknown	unknown	gnl\|CDD\|378981
NZ_CP004078.1\|WP_025336739.1\|4778674_4781548_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP004078.1\|WP_025336754.1\|4799110_4802131_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP004078.1\|WP_025336736.1\|4774970_4776056_-\|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP004078.1\|WP_025336746.1\|4789072_4789465_-\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NZ_CP004078.1\|WP_025336753.1\|4797121_4798918_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NZ_CP004078.1\|WP_025336748.1\|4791442_4792795_+\|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPA	unknown	unknown	gnl\|CDD\|234769
NZ_CP004078.1\|WP_025336747.1\|4790248_4791352_+\|glycine-cleavage-system-aminomethyltransferase-GcvT	unknown	unknown	gnl\|CDD\|234742
NZ_CP004078.1\|WP_025336752.1\|4796032_4796845_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NZ_CP004078.1\|WP_025336755.1\|4802343_4803228_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	8.14897e-52
NZ_CP004078.1\|WP_025336750.1\|4794377_4795328_-\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	7.28961e-69
NZ_CP004078.1\|WP_025336743.1\|4786349_4787573_+\|AGE-family-epimerase/isomerase	gnl\|CDD\|225493	COG2942, COG2942, N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism].	5.68635e-108
NZ_CP004078.1\|WP_025336748.1\|4791442_4792795_+\|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPA	gnl\|CDD\|234769	PRK00451, PRK00451, aminomethyl-transferring glycine dehydrogenase subunit GcvPA.	0
NZ_CP004078.1\|WP_025336735.1\|4773023_4774943_-\|hypothetical-protein	gnl\|CDD\|377924	pfam07833, Cu_amine_oxidN1, Copper amine oxidase N-terminal domain. Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.	2.63069e-14
NZ_CP004078.1\|WP_025336741.1\|4784272_4785052_+\|flagellar-motor-protein	gnl\|CDD\|181654	PRK09109, motC, flagellar motor protein; Reviewed.	1.02425e-90
NZ_CP004078.1\|WP_025336742.1\|4785048_4785924_+\|OmpA-family-protein	gnl\|CDD\|235887	PRK06925, PRK06925, flagellar motor protein MotB.	2.9674e-58
NZ_CP004078.1\|WP_025336740.1\|4782098_4784090_-\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP004078.1\|WP_025336749.1\|4792791_4794252_+\|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPB	gnl\|CDD\|235292	PRK04366, PRK04366, aminomethyl-transferring glycine dehydrogenase subunit GcvPB.	0
NZ_CP004078.1\|WP_025336738.1\|4776901_4778536_+\|ferredoxin--nitrite-reductase	gnl\|CDD\|236572	PRK09566, nirA, ferredoxin-nitrite reductase; Reviewed.	3.19811e-170
NZ_CP004078.1\|WP_025336751.1\|4795502_4795988_+\|DinB-family-protein	gnl\|CDD\|378981	pfam12867, DinB_2, DinB superfamily. The DinB family are an uncharacterized family of potential enzymes. The structure of these proteins is composed of a four helix bundle.	9.19666e-10
NZ_CP004078.1\|WP_025336739.1\|4778674_4781548_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP004078.1\|WP_025336754.1\|4799110_4802131_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP004078.1\|WP_025336736.1\|4774970_4776056_-\|trypsin-like-peptidase-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.66042e-54
NZ_CP004078.1\|WP_025336746.1\|4789072_4789465_-\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	1.16769e-62
NZ_CP004078.1\|WP_025336753.1\|4797121_4798918_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	8.11965e-109
NZ_CP004078.1\|WP_025336747.1\|4790248_4791352_+\|glycine-cleavage-system-aminomethyltransferase-GcvT	gnl\|CDD\|234742	PRK00389, gcvT, glycine cleavage system aminomethyltransferase GcvT.	0
NZ_CP004078.1\|WP_025336752.1\|4796032_4796845_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	9.2568e-29

>NZ_CP004078.1|WP_025336744.1|4787720_4788362_+|hypothetical-protein
MASLVRALRDPNRWRTTLYTVGLPLVSLAFHAVFLMFLMIFGGFVFFFGVSPHLFWDVPSGMPTGWRLSVIRSYLLAFGALYALVWCGYWWILRALNDGKIRAFPLHVLAAWLPLLAGVYFADPVNNPNAMIPTPVAEITFTMSTALMTTSLFPFYSAAVYWLVFSPSIRRPRKIGRLLGLWILFAAACLFLEPFFWHLAPSIYEGIAGFPTR
>NZ_CP004078.1|WP_025336743.1|4786349_4787573_+|AGE-family-epimerase/isomerase
MNDSPITRPDFADPSFLKRHILDTVRFYAPRCIDHVNGGYINCFLDDGTVCDYETKHLVGMTRFIYTFSAALLVGGPEKYRGAVEHGLRFLRECQWDHEHGGYFWTLKGRNPVDKRKLAYGNAFALLAASTALKAGIPTARAVIGEVYEVLEKHFWNEQDGLYADEASRDWSDVSPYRGQNANMHLTEAMMAAYEATGEKRYLDRAYTLAHSVMFKLLPLSGQLIWEHYTADWGIDWNYNKGNNKDEFRPYGYIFGHSIEWAKLLLLLNRVCPQAWLVPQAERLFREAVDKGLDRQHGGIFYSMSPEDGRIIDSDKRYWVMAETIGAAALLAEGTGQPEYRKFYEDIFGYCWTHFVDHTYGAWYQLLDASNRKYNSIKSPPPKTDYHPITNCITAISVWETAAGKSF
>NZ_CP004078.1|WP_025336742.1|4785048_4785924_+|OmpA-family-protein
MRQRGQRIRRRESREHRDRWMITYADLITLLLIFFVVLYAMSSLDQEKYGSVIASLQRSFQTGSGILDGGSGVLNGGNGLKNGQNSTGSGSTGLSSPSPASSAGASAGTGDGSGQVGATPSAEASPSPRELAFRRQEAKLAELMNVITRYVKDNQLGDQIFVADKPQGIAITLSDRFLFDVGKADLKPAAFPALRQLSGLFRGIGATVSIEGHTDNTPVLPSSRYKDNWELSGARALSVLRFFLDEESLSPGQFQYAGYADTRPAADNTMESGRQKNRRVEIIVLRQLQEE
>NZ_CP004078.1|WP_025336741.1|4784272_4785052_+|flagellar-motor-protein
MDITSIIGIIAGLAALIGGFFWEGGRVSGLLQWNAALIVFGGTIAAVMISFPARTLRDVPAAVKMAFGLSRTRLDEQAEELVEMAQISRRSGVLSLESRAEAHPDPFTREGLQLIVDGTDPGQVRQILELEMDAAELKAERYAKIFEAAGGYAPTMGIIGTVMGLIRVLGNLTDPSHLGPSIAVAFTATLYGVASANLLLLPIASKIKARSQLRLHGMEMLLVGILSVQNGDHPLLVRKKLASFLQDGTAENATVGVQP
>NZ_CP004078.1|WP_025336740.1|4782098_4784090_-|excinuclease-ABC-subunit-UvrB
MNDIVVSTKTFQLESEYTPQGDQPRAIGELVEGLSAGMKHQTLLGATGTGKTFTIAQMIAKVNRPTLVIAHNKTLAAQLASEFKEFFPQNSVDYFVSYYDYYQPEAYIPSSDTYIEKDSSINEEIDKLRHSATSSLFERRDVIIVASVSCIYGLGSPQEYGSLLLSLRVGMEKPRNQILSRLVDIQYQRNDINFVRGTFRVRGDVVEIFPASQGEHAIRVELFGDEIERITEIDVLTGELIGEREHVAIFPASHFVTQEETMRLALVNIERELEERLAVLRDAGKLLEAQRLEQRTRYDIEMMKEVGFCSGIENYSGPLTFRERGATPYTLLDYFPDDMLIVIDESHVTLPQIRAMYNGDQARKTVLVEHGFRLPSALDNRPLRFEEFEEKVKQIVYVSATPGPYELEKCDTMVEQIIRPTGLLDPIIEVRPTEGQIDDLIGEIRERLDRDERVLITTLTKKMSEDLTDYLKEIGIKVRYLHSDIKTLERIAILRDLRLGTFHVLVGINLLREGLDLPEVSLVAILDADKEGFLRSERSLIQTIGRAARNSEGKVLMYGDHITESMDKAITETQRRRSIQIAYNEQHGITPQTIRKRVRDVIEATKVAESKADYLTGAGGKMSKKERQSLMQRLEAEMKEAAKNLQFERAAELRDALLELRAE
>NZ_CP004078.1|WP_025336739.1|4778674_4781548_-|excinuclease-ABC-subunit-UvrA
MANENIVIKGARAHNLKNIDVTIPRDRFVVLTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMEKPDVDSIDGLSPAISIDQKTTSRNPRSTVGTVTEIYDYLRLLFARVGHPHCPDHGIEITSQTVEQMVDRIMQYPEKTRLQILAPVISGRKGEHKSLFADISKQGFVRVRVDGELRDLSEDIELEKNKKHTIEVVVDRIVIKDDIESRLSDSIETALKLSGGKILVDIIGQEELLFSSNFACPICGFSMEELAPRMFSFNSPFGACPECDGLGAQMVVDPDLLVPEPEKSIEDGAFLAWTGSTSNYYPQFLKSVCEHFHIPQDVPVSELSPEHMNKLLNGTGSEKIRFRYENDFGQRKEALVPFEGIIPNLQRRYRETASDGIREFIEGFMSAKPCPVCKGKRLKREILGVTVGGKNIADVTDLSIGDGQRFFGELSLNEKEAAIANLILKEISSRLGFLVNVGLDYLTLSRSAGTLSGGEAQRIRLATQIGSSLMGVLYILDEPSIGLHQRDNDRLISTLAHMRDLGNTLIVVEHDEDTMLASDYIIDIGPGAGIHGGRVIAQGTPEEIMNDPNSLTGEYLSGRKFIPVTSKRRETDGRWLEIRGAKENNLKNVNVKIPLGVFTAVTGVSGSGKSSLVNEILYKSLARELNKAVKVRPGQHKEIRGLDLLDKVIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAKTNEAKIRGYQKGRFSFNVKGGRCEACRGDGIIKIEMHFLPDVYVPCEVCKGKRYNRETLEVKYKGKNISDVLEMTVEDGTEFFQNIPKIHRKLQTLLDVGLGYIKLGQPGTTLSGGEAQRVKLASELYRRSTGKTLYILDEPTTGLHVDDIGRLLEVLHRLVESGESVLVIEHNLDVIKTADHIIDMGPEGGSGGGTVVATGTPEKIIEVPESYTGKYLKPILHRDRERTEALTLQAAEAN
>NZ_CP004078.1|WP_025336738.1|4776901_4778536_+|ferredoxin--nitrite-reductase
MAYEPIWTKEPDKLSKFELVKLEKDGLDVIRTIIEKYALEGYDSIPADDLDLFKWAGVYQQKPKNGHFMMRVRINSGIMTSAQARTLADISRLYGRELVDITTRQAIQFHWLTVENFPDIFKRLDAAGLYSFEACGDCPRTIVGNPLAGIDKDELLDTKALVDEVNSFFMLNRDFSNLPRKLKMSISANPYNNAHAEINDLAFTPAVKEIDGEEFIGFHVMVGGGLSAKPHLAQKLDIFVRPDEVLKVATGVATIFRDYGYREKRHHARLKFLMADWGAEKFKDKLVELIGELPARGEDKTIGWQAAYFYGVQPQPQQGLNYVGLNVPVGRLNADELTQLADLADAYGDGHIRTTMSQNAILSGVPDDKVDELLAAPLLKRLAPAPKPFISRTVACTGNEFCSLALVETKKRAVAIAEFLDERLALDENVRFHLIGCPNACGQKQIADIGLQGALLKTPEGMVEAYDIAIGGTLGGGAQGPAAKFAQPLKGRVKADEVAGVIEQLLLFYKSERAAGEGFHAFAERVGLPAFQDKLSSILAAPAS
>NZ_CP004078.1|WP_025336737.1|4776218_4776428_-|hypothetical-protein
MLLAEAATATASRFHTFDVFMILFTVLIATGVIRLLRAPQKNKFAIAFGVVSLLVFLISDYAMVKYWLS
>NZ_CP004078.1|WP_025336736.1|4774970_4776056_-|trypsin-like-peptidase-domain-containing-protein
MRNQASRLLLCGLAVGLALSLSVPVSAAAASVNPSSKKAVLQAADPVPQIYARVSPSVVGIIGKAQGGKNTGLDNRYNLVHGSGVILTSGGWIVTNAHVIQSMQKATVVTSDGKSYSVTDYYADELSDIAILKINAAHLKSASLAGASSVKVGEKVVAIGAPLSFALRNSATVGVVSGSGRVVDASYRLLQSDAAINPGNSGGPLVDMNGKVIGIVSMKYSAVGVDNTGFAIPAETVRYIIKQLFTYGEVRRPSLGLELQQSWSSIVGLPAEDPLTVTKAVSAAARKADIAEGDELYSIDGHRVTSAVDINELFKSYRPGQTVQLLMQSGGDIVQRKLVLGEGDPIVGTDDGGSADDETEE
>NZ_CP004078.1|WP_025336735.1|4773023_4774943_-|hypothetical-protein
MNKMCLKVLHAALAALIILAMLPVNDAGAAEKEKLMLTLKVGSKQAKANGQSIVIPPPFSENGSVLVPLGVFKKAFGSGVSLAKDNVVKVTFGPHTGAMTIGGTTAWRDGQKVKLAAPPRMVNGVLMVPLRFAAGVIGAKVSAGSGGSIVVALPAANSANSGDGSLPEGGIDSEAGKTKVGNSYEEWSMQYPAGLIIGDSGGEEGVSSFMSADNAYYLEVHVTTQEAASDADDLLDQLVRSSEDGGEVVLDREVFPKAAIPYARIVSKDPSGALWEGRAYYANGRLYKLYLTDDRAENYKDFAKYAGLLNSFRPSFDEKDRSIRDLSTVLNGMRSAGSDDYGISLEVPAGWSLDNRHLVYESKDGSYLKLNISSAPPASTLDSWEEELRQKDAELFVQEAYSEQKITDAEISGVPARVRKVRYNDGGGWMTVYQTLLLKNGYRYYTEYAAAGQDEDQAKFAAVLASLKIDFDTVKENFGRLEQDDYPSLKNKTVTKTSKIYGYSIDMPRLWTPYQGVFDMQSVDYRFTGGRFQIAVLPEGSMEYTVNQLKEFYRNAAGDPQGPFIEQERETTFAGVPAVEVTVRQTKNGIPSHIRVFVFSREDIVYTLTATLGDANATEVQQAMLDRTFQSFRFTDEGK
>NZ_CP004078.1|WP_025336746.1|4789072_4789465_-|glycine-cleavage-system-protein-GcvH
MSEVLDNLRYSEEHEWAQQGEGQIVRVGITDHAQHLLGDIVFVEFPEIGTAVSAGDSVGSIESVKTVSELYSPISGTVTRVNEALEDSPELLNGQPYGEGWIYEVEIEGDYASATAGLLDAAAYRELVGE
>NZ_CP004078.1|WP_025336747.1|4790248_4791352_+|glycine-cleavage-system-aminomethyltransferase-GcvT
MSALKRTPFFAFYSAYPESRSIDFGGWELPVQFAGIQKEHEAVRSRAGLFDVSHMGEFMVTGSGAEAYLQRMTTNDVGRLADGQAQYSLLCYPDGGTVDDLLVYRLGEGRYMLVVNASNIGKDFQWLQDHLPESGVELTDRSEETLLLAVQGPHAERIISEVTDVPLADLKPFHFVERAAVCGVEVLLSRTGYTGEDGFELYAPVDAAAALWNGLLEAGSAHGLMPAGLGARDTLRFEAKLPLYGQELSQDISPLEAGLGFFVKLDKADFIGREALLAQKEQGVPRRLVGIEMIDRGIPRSHYPVYAGGQQIGEITTGTQSPTLKRNLGLALVDARYGEIGTELEVEIRGKRLKAAVVKAPFYKKSR
>NZ_CP004078.1|WP_025336748.1|4791442_4792795_+|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPA
MKHRYLPMTEQDRSEMLAEIGIQSVEELFADIPEAVRYKGRLPMSEALDEYALLRHMKRLSDKNADFDSHISFLGAGLYDHHVPVVINHVISRSEFYTAYTPYQPEISQGELQAIFEFQSYICELTGMKVANASMYDGATALSEAAVLASGATKRKKIVVSSAVHPEARQVLKTSAAGLGLEIAEVGCTDGVTDLALLAQAIDGDTAAVLVQYPNFFGCIENLAAIEKLTHDAKALLVVSANPLALGVLETPGKLGADIVVGDAQPLGINASLGGPTCGYFAVAEHLMRRIPGRIVGQTVDRSGKRGFVLTLQAREQHIRREKATSNICSNQALLALCASVYLSVMGKEGVREVGGLNIRKSHYAAARLGAIQGVKVAFGSPFFNEFVLKLPEGSDPGAVNAKLLKEGFLGGYDLGKDYPELAGHMLIAVTEKRSKSEIDEFASALEGCL
>NZ_CP004078.1|WP_025336749.1|4792791_4794252_+|aminomethyl-transferring-glycine-dehydrogenase-subunit-GcvPB
MKPEQSLIFELSRPGRAAYSLPECDVPAEEGLDTLIPAELLRSEPAVLPEVSEVDVIRHYTALSRRNFGVDNGFYPLGSCTMKYNPKINEDVARFPGFAKIHPYQPEESIQGALELMHTLQSDLAALTGMDAVSLQPAAGAHGEWTGLMMIRAYHEARGEVRTKVIVPDSSHGTNPASASAAGLTTVTIPSNEQGMVDLEALKQAVGSDTAALMLTNPSTLGLFETQIVEIARIVHEAGGLLYYDGANSNAIMGITRPGDMGFDVVHLNLHKTMSTPHGGGGPGAGPVGVKAKLAPFLPGPTVAKTEDGGFKLQAGGPQSIGRVKAYYGNFGILVRAYTYIRTYGPDGLREVSENAVLNANYMLSRLAPHFEVPYPGICKHEFVLSGKNLKPYGIRTLDVAKRLLDFGYHPPTVYFPLNVEECIMIEPTETESKETLDGFIDTMIRIVQESKETPEIVLNAPHTTEISRLDETQAARKPVLNCSCG
>NZ_CP004078.1|WP_025336750.1|4794377_4795328_-|YafY-family-transcriptional-regulator
MPKSKRLLELMLTVNRKRKFTVKELAQEFGVSPRTILRDLQELGELGVPLYSEVGPHGGYQVLNERILPPIAFTEEEAVALFFACHALRHYSFIPFETEASSALGKFYHYMSGDVRDRIDQMKNRVDFVIPVRQAESPFLSALLEAAVMQKVLRIGYKSQENVTVRDIQPIGIYASSGLWYCPAYCFLRGGVRLFRCDRIISVEEGDPEIKPLDLRSIHLDNWEDSFSDKSRYARCRVQLSEEGVRVCEAELGRRGLLQVREDGTGWIDGDIPIGEIPYFARLFIGLGSDAEVAEPLELIDCMRVKLKELLAKYDA
>NZ_CP004078.1|WP_025336751.1|4795502_4795988_+|DinB-family-protein
MQAIIEMKGLLLHELEHIVRTSSKLIAKISPEHWDYRPRENMRSLLELAQHLVSVPSVDLLILQEQGQPDIRRTEEEINEARTAEKLSAWMDKGFQDLKAYMEGLSEEDFLHKATKPFYLEQGSVQAKWLIEIVTHAQHHRAQLFNYLKELGYEVNMFDLY
>NZ_CP004078.1|WP_025336752.1|4796032_4796845_+|alpha/beta-hydrolase
MTDPIPNNHDSVSYHRKSFEGPDTVLSYIDFGGGGPPLVALHGHMNEGLFARHLAERFAREYRVIALDQRGHGESGRPASFDNDRYVADALALLDHLGIDHAVLLGHSLGGVVAYRLAARRPERVRALIIEDIGAAVDDDLGFAAEWPRRMPTREALIAVLGRLGPAFAYSMRQYEDGWGLPFVPEDMIRSQRKLNGNHWDDWLATDCPALLLHGMRSNCLSYGQAEEMARRRPNTKLVHLDAGHTIHFDAPDRYLEEIEQFLTETGAHS
>NZ_CP004078.1|WP_025336753.1|4797121_4798918_+|EAL-domain-containing-protein
MLRKNNNKGTHNSTWLRRSSYEEIRPQHLNTQSFSPLWGASRIAGIYFIIGCLWILLTDKAVSALTSNADLIATINMVKGWFFVFMTALLIFVLILETLKRIRKVEEDLEVSYKNLMNTHENLESAYEEITATEEELRQQYDQLIENQRKLSDSEEKMQHLAYHDLLTDLPNKLNLYENGANLLAGSRGSAALMFVDIDNFKYINDTMGHGFGDRLIVEASKKLLSIVGDHGVIYRFGGDEFIILLHSLTDKGEAGMMASRILAGLKEAVDIDNSLVHISTSVGISLYPDHGSDIMELVKRADIAMYKAKEAGKGNFIVFDNPLNDTFAERMNIEKQLYTAMERNEFDLYYQPQVDLALNKVTGLEALLRWNSPELGPVSPFKFIKVAEDSHLIIPLGSWVLRKACAFLKKLHEQGFEHLTMSINISMLQLLQTDFNEVVLDTLHSSGLEPDYLELEITESILIQSYEHVGTKLNELREKNIKIALDDFGTGYSSLSYLTHLPISTLKIDKSFIDSIPAETNQAILLEQMLMIGKRMNMCVIAEGVERAEQLAYLQEQGCDKIQGYLFSKPLAAKEVERLLAGWECSGLFFSKSTETC
>NZ_CP004078.1|WP_025336754.1|4799110_4802131_-|efflux-RND-transporter-permease-subunit
MTWLTKWAFGNKAAAGLLIVMALVVGVMSYSSLPMEFMPEADNPQVTITALGPGQDAHSMEEKVTKPIEAAVSTVKGKTGMTSTSGDSFTKVDLNFDSKTNMKDAAQEVQKAVDSLQFPQGVMKPFVLQLNTSMIPVSQVTLAFDQGITKENLKLAETTIIPELQKIEGVANVALYGKTAPQVTVKLDPRLMAEKKVSVQQITGLLQGRTVSASIGEQTLGGQTGSVSVVSSIDSIDTLKKLPVSPGVTLQDIATVQEKSDQESVSRSNGKDVLFAVVTKEANANAVAVGNKVRDAVDSINKDVKGTEAAVVFSTSDMVVDSVNSMMREVLLGALFATIVILLFLRNLRATLVTAVSIPLSLAVTLYLLDISGITLNIITLGGVAVAVGRLVDDSIVVIENIYRRLQKESFSVDMMISATKEVARAITSSTVATVAVFLPMGLLRGGLQAFLLPFALTVTYSLLTSLVVALTVVPLLSSVLLRNTSMKEHDPSKGFQRFLKWNLNHKWVSLSLGLIILVSSIAAYMNMPKGALDASDASFVSVEMKYPNDTPVAEVLDQGKRLEQDLMKLPQAETVLMQSGNSADSAKWGSVSSATVVNFTVALKKNVDGQAFIDAVRGMQKTFDGATLTANEASIMGSATTSEYVDIAGEDLSKVTAAAGQVMDKVKTIDGIQKISSNMEDTKPVFAFNVNPAQVNAQEISMQLAAVLNPIPIGEMQLNGSPASVVLSPLAEPKSQADLQNITLMTSTGPKPLSQLASLEVREEPAMLYRKEGKPYVRITAEVDPKKVSEIGASIKKETDSVKLPEGVTIISGGASADQAGDFKDLGMTALISIGLVYLIMVITFKTLRAPLAIMFSLPLAAIGAVVGLLVSGVTPDFTAVFGALMLIGIVVTNAIVLIDRVKQNEAHMSIRDAILEAAGTRMRPILMTAIATICAMLPLLFGHSEQGSIVSQSLAIVVVGGLTAATVLTLIIVPAVYELFYFRKSAKQRKKALKPAAYPAAGTN
>NZ_CP004078.1|WP_025336755.1|4802343_4803228_-|LysR-family-transcriptional-regulator
MSLLKYEVFQTIVDLGSLARAAETLGLTQSAISHALSSLEDELGCVLMIRNRTGVRLTANGERVLKHVRNMLGCHEQLKQEVAAIHGIEAGMIRIGTFSSISINWLPGIMRRFREEHPRIEIRLVNGDFEEIEDGLKNGTIDLGFMSLPALGNFEIIPLREDRMVCIVPEEHQLSGMERITFAQMEQESFIMPTPGCDQDVRRVLQKLPCQPRVQFLAGDDYAIIAMVENGLGISIISEMILKSRGSRVAMLELEIPCSRSLGIVVPSRKQASPAAHKFIELARRWVEEWRLPS

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Crispr_ID: NZ_CP004078_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP004078_8

4812651-4812739

Orphan

Consensus_repeat	Method
CTTTCGGCTGAACAAACGGCTATTGAACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP004078_8

>merge|NZ_CP004078|8|4812651-4812739|CRISPRCasFinder
CTTTCGGCTGAACAAACGGCTATTGAACCCCTTGTTCCCTCGGCGGGCTCCCCCGGCCAGCTTTCGACTGAACAAACGGCTATTGAACC

>NZ_CP004078|8|8|4812651-4812739|CRISPRCasFinder
CTTTCGGCTGAACAAACGGCTATTGAACC	CCTTGTTCCCTCGGCGGGCTCCCCCGGCCAG
CTTTCGACTGAACAAACGGCTATTGAACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP004078.1\|WP_025336755.1\|4802343_4803228_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP004078.1\|WP_025336762.1\|4814980_4816447_-\|S41-family-peptidase	unknown	unknown	gnl\|CDD\|223864
NZ_CP004078.1\|WP_025336763.1\|4816565_4817879_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP004078.1\|WP_025336764.1\|4817926_4818841_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225088
NZ_CP004078.1\|WP_084266674.1\|4813330_4814701_-\|serine-protease	unknown	unknown	gnl\|CDD\|214570
NZ_CP004078.1\|WP_025336757.1\|4807519_4808692_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NZ_CP004078.1\|WP_025336769.1\|4822869_4824501_-\|pilus-assembly-protein-PilM	unknown	unknown	gnl\|CDD\|227306
NZ_CP004078.1\|WP_144240568.1\|4821931_4822111_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_025336766.1\|4819802_4821230_+\|VanW-family-protein	unknown	unknown	gnl\|CDD\|377286
NZ_CP004078.1\|WP_025336758.1\|4808706_4809642_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP004078.1\|WP_025336767.1\|4821480_4821900_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341373
NZ_CP004078.1\|WP_025336752.1\|4796032_4796845_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP004078.1\|WP_025336754.1\|4799110_4802131_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP004078.1\|WP_025336760.1\|4811171_4811816_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP004078.1\|WP_025336756.1\|4803398_4804322_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP004078.1\|WP_038596217.1\|4806303_4807527_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NZ_CP004078.1\|WP_025336765.1\|4818830_4819517_-\|cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438
NZ_CP004078.1\|WP_025336753.1\|4797121_4798918_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NZ_CP004078.1\|WP_025336768.1\|4822220_4822886_-\|type-4a-pilus-biogenesis-protein-PilO	unknown	unknown	gnl\|CDD\|377391
NZ_CP004078.1\|WP_025336759.1\|4809869_4811126_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951

Protein	Function_ID	Function_description	E-value
NZ_CP004078.1\|WP_025336755.1\|4802343_4803228_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	8.14897e-52
NZ_CP004078.1\|WP_025336762.1\|4814980_4816447_-\|S41-family-peptidase	gnl\|CDD\|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	1.14154e-119
NZ_CP004078.1\|WP_025336763.1\|4816565_4817879_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	2.39083e-44
NZ_CP004078.1\|WP_025336764.1\|4817926_4818841_-\|ABC-transporter-permease	gnl\|CDD\|225088	COG2177, FtsX, Cell division protein [Cell division and chromosome partitioning].	3.75794e-85
NZ_CP004078.1\|WP_084266674.1\|4813330_4814701_-\|serine-protease	gnl\|CDD\|214570	smart00228, PDZ, Domain present in PSD-95, Dlg, and ZO-1/2. Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides; others appear to bind internal (non-C-terminal) polypeptides. Different PDZs possess different binding specificities.	1.23745e-07
NZ_CP004078.1\|WP_025336757.1\|4807519_4808692_-\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	9.58171e-26
NZ_CP004078.1\|WP_025336769.1\|4822869_4824501_-\|pilus-assembly-protein-PilM	gnl\|CDD\|227306	COG4972, PilM, Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion].	7.6885e-20
NZ_CP004078.1\|WP_025336766.1\|4819802_4821230_+\|VanW-family-protein	gnl\|CDD\|377286	pfam04294, VanW, VanW like protein. Family members include vancomycin resistance protein W (VanW). Genes encoding members of this family have been found in vancomycin resistance gene clusters vanB and vanG. The function of VanW is unknown.	3.13638e-62
NZ_CP004078.1\|WP_025336758.1\|4808706_4809642_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	7.19991e-108
NZ_CP004078.1\|WP_025336767.1\|4821480_4821900_+\|hypothetical-protein	gnl\|CDD\|341373	cd04598, CBS_pair_GGDEF_EAL, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and is thought to be involved in regulating cell surface adhesiveness in bacteria. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	2.6584e-13
NZ_CP004078.1\|WP_025336752.1\|4796032_4796845_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	9.2568e-29
NZ_CP004078.1\|WP_025336754.1\|4799110_4802131_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP004078.1\|WP_025336760.1\|4811171_4811816_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.04129e-75
NZ_CP004078.1\|WP_025336756.1\|4803398_4804322_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.73975e-15
NZ_CP004078.1\|WP_038596217.1\|4806303_4807527_-\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	2.16548e-22
NZ_CP004078.1\|WP_025336765.1\|4818830_4819517_-\|cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	9.98885e-134
NZ_CP004078.1\|WP_025336753.1\|4797121_4798918_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	8.11965e-109
NZ_CP004078.1\|WP_025336768.1\|4822220_4822886_-\|type-4a-pilus-biogenesis-protein-PilO	gnl\|CDD\|377391	pfam04612, T2SSM, Type II secretion system (T2SS), protein M. This family of membrane proteins consists of Type II secretion system protein M sequences from several Gram-negative (diderm) bacteria. The precise function of these proteins is unknown, though in Vibrio cholerae, the T2SM (EpsM) protein interacts with the T2SL (EpsL) protein, and also forms homodimers.	3.92617e-05
NZ_CP004078.1\|WP_025336759.1\|4809869_4811126_+\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.94778e-34

>NZ_CP004078.1|WP_025336760.1|4811171_4811816_+|response-regulator-transcription-factor
MIKVVIVDDDSFIRESLKVLVGMDPDIEVTGAAADGGEALRLLESGTEANVVLMDIRMPGVDGVEGTRLIKRGFPQAAVLMLTTFDDDEYIIEALKGGASGYLLKNIPPDRIIQGIKTVHEGNMLIHPDIARKLAGFLQPAAAETASCSLDSYGLTKTELSVVAAIAEGYSNKEIAAELFLSEGTVKNYITEILSKLGLRDRTQIAIFYLKNQR
>NZ_CP004078.1|WP_025336759.1|4809869_4811126_+|histidine-kinase
MTKELKLLRYGLIAVPAFLSMYVQEYISYDRFTLHLLILLLLAALGARLPARFTAAMTAAEMLYASWLCFRYGSLMALPSLSALLVYSRFRPRPLPFVFAGIHLAALNAAVMEASPLIRAWVNLVFLLAAALAAQLHSAGRGKEETLHLYDELRKKHFELDEARSRLLQFAAQVENAAQAEERVRISRQLHDDIGHRLIRVKMMMEAALHTLPSAPEAGMTMMDQVRDQLAGCMDDLRFAVRRIGGKPQLEGAYALDRLLEETGRDTGIETSYTVEGTPYPLYPSLQVVLYKNAREAITNGLRHGLATSVGIKLRYSPSEVTMEISNNGRADMVECGNEMAESSGGNRGEGDNRDDGNRSERLAGGNREFRLAGGGGGMGFRGMEERTRLVGGTLQVRSAYPFTVITTLPVYKQSEII
>NZ_CP004078.1|WP_025336758.1|4808706_4809642_-|ABC-transporter-ATP-binding-protein
MALAQLTDVVKRYESNLTVDHVNLSIKEGEIFGLLGPNGAGKSTTISMLCGLLKSDGGSIVIDGISVSKQPLEAKKRIGLVPQDLALYENMTAQENATFFGKLYGLRGGLLKERVQEALEFTGLADRAKDKPSTFSGGMKRRLNIACAIMHRPKLIIMDEPTVGIDPQSRNHILESVKALNKLGSTVIYTSHYMEEVEAICDRVAIMDKGHIIACGTEQELRERVAHEEKIVIQAGNITPGLIQELKQHPRVTRVEADGEKVELYLPSSQGELQDILFIFAKHGGVIQALQIEEPDLETLFLSLTGRTLRD
>NZ_CP004078.1|WP_025336757.1|4807519_4808692_-|ABC-transporter-permease
MTNIWTIAAYELRRLFRSRTMLINLFLLPILLIFLLGSALSGVVGTGKDQTIDPLRVGIVDAAASPSERSQMVGSFLKSPEIAKLIIPEAAGSREAAESGVRSGEYAYAVIIPAGFDRDVQSGKEAKLEYILGKDRSDNMVAATVFDNFLSRINYTQAAALTLGPQVIPAMAQPGQGGPSAVLGKLNEGGNSYTASQYYAAAMLLMFLLLSGQTVISSLFSEKDNHTLFRIGSMPVKGSEIFVGKMLGIGLVTVLQGAVIIFATHFLFGVYWGNRPWLLALVCLLMILASLTLSVIISMFVQTAASARSISSGLTVVMTFISGGMAPLPDSFVNTGGAFSINYWGLRSVLRMMLETPLSQISGNVAMLSLICLVLLGLAFFSYRKVGYHA
>NZ_CP004078.1|WP_038596217.1|4806303_4807527_-|ABC-transporter-permease
MHNIMTIAWNLAKRMIGSRRGLIAYILMPGVIVSLIIWMTGGPGNHKTNVLYSNLDQGSAGVHVIAELEKTGEYNLIEKKSEDELRAGVLNEEGSAGLEVPAGYTASLLAGQTPPIHIYELKTTETSITLKMKAGEIGDRLRELALAVGAAGTGTGSAAGTAETPVAAKTADATVSTAPAREAKLSSILLLAEQHRVGGVKTDYNLYPRQSLDTVTGFMLMFLMAMVTSSVSVIMDDRRQRTMMRIFSAPVRSYEIAIGNFLGSFTVGVIQIAVVLLVGRYVLNYDYELPMYIYFLVLAAFMLVSMGLASTVAGLIRNPNNAGMLNALILTPTCMLGGCFWPISIMPDFMQKAANFVPQKWAIQAADLAATGSGWSELWLPFAVLGLMAAVLLAIGSAILRPNEAAI
>NZ_CP004078.1|WP_025336756.1|4803398_4804322_+|DMT-family-transporter
MKQRNADLLMMLVTLSWGSSYLFMKNGLNSVSPFNLVALRFLLAFILCGAIWFKRLRLADKRTLGYSLVLGFLLFAVSASVIFGLRSTSTSHAGFLASLTVIFVPALSVVVLNQKPGARLIAGACVTMTGIGLLTLSGPMSVKPGDLLCILAALLYAVHILVTGAAAKVADPLNLGILQLGFAGGLGLLFSFLFESPQVPVTLEGWISVLMLSVVCSAAGYIIQSIAQKYTTPTHTGLIFALEPVFAAAFAYVFADEHLSVRGYIGAALILSGLFIAEMQRGRTSPKGMKSATTSKPPGMAFKSAKN
>NZ_CP004078.1|WP_025336755.1|4802343_4803228_-|LysR-family-transcriptional-regulator
MSLLKYEVFQTIVDLGSLARAAETLGLTQSAISHALSSLEDELGCVLMIRNRTGVRLTANGERVLKHVRNMLGCHEQLKQEVAAIHGIEAGMIRIGTFSSISINWLPGIMRRFREEHPRIEIRLVNGDFEEIEDGLKNGTIDLGFMSLPALGNFEIIPLREDRMVCIVPEEHQLSGMERITFAQMEQESFIMPTPGCDQDVRRVLQKLPCQPRVQFLAGDDYAIIAMVENGLGISIISEMILKSRGSRVAMLELEIPCSRSLGIVVPSRKQASPAAHKFIELARRWVEEWRLPS
>NZ_CP004078.1|WP_025336754.1|4799110_4802131_-|efflux-RND-transporter-permease-subunit
MTWLTKWAFGNKAAAGLLIVMALVVGVMSYSSLPMEFMPEADNPQVTITALGPGQDAHSMEEKVTKPIEAAVSTVKGKTGMTSTSGDSFTKVDLNFDSKTNMKDAAQEVQKAVDSLQFPQGVMKPFVLQLNTSMIPVSQVTLAFDQGITKENLKLAETTIIPELQKIEGVANVALYGKTAPQVTVKLDPRLMAEKKVSVQQITGLLQGRTVSASIGEQTLGGQTGSVSVVSSIDSIDTLKKLPVSPGVTLQDIATVQEKSDQESVSRSNGKDVLFAVVTKEANANAVAVGNKVRDAVDSINKDVKGTEAAVVFSTSDMVVDSVNSMMREVLLGALFATIVILLFLRNLRATLVTAVSIPLSLAVTLYLLDISGITLNIITLGGVAVAVGRLVDDSIVVIENIYRRLQKESFSVDMMISATKEVARAITSSTVATVAVFLPMGLLRGGLQAFLLPFALTVTYSLLTSLVVALTVVPLLSSVLLRNTSMKEHDPSKGFQRFLKWNLNHKWVSLSLGLIILVSSIAAYMNMPKGALDASDASFVSVEMKYPNDTPVAEVLDQGKRLEQDLMKLPQAETVLMQSGNSADSAKWGSVSSATVVNFTVALKKNVDGQAFIDAVRGMQKTFDGATLTANEASIMGSATTSEYVDIAGEDLSKVTAAAGQVMDKVKTIDGIQKISSNMEDTKPVFAFNVNPAQVNAQEISMQLAAVLNPIPIGEMQLNGSPASVVLSPLAEPKSQADLQNITLMTSTGPKPLSQLASLEVREEPAMLYRKEGKPYVRITAEVDPKKVSEIGASIKKETDSVKLPEGVTIISGGASADQAGDFKDLGMTALISIGLVYLIMVITFKTLRAPLAIMFSLPLAAIGAVVGLLVSGVTPDFTAVFGALMLIGIVVTNAIVLIDRVKQNEAHMSIRDAILEAAGTRMRPILMTAIATICAMLPLLFGHSEQGSIVSQSLAIVVVGGLTAATVLTLIIVPAVYELFYFRKSAKQRKKALKPAAYPAAGTN
>NZ_CP004078.1|WP_025336753.1|4797121_4798918_+|EAL-domain-containing-protein
MLRKNNNKGTHNSTWLRRSSYEEIRPQHLNTQSFSPLWGASRIAGIYFIIGCLWILLTDKAVSALTSNADLIATINMVKGWFFVFMTALLIFVLILETLKRIRKVEEDLEVSYKNLMNTHENLESAYEEITATEEELRQQYDQLIENQRKLSDSEEKMQHLAYHDLLTDLPNKLNLYENGANLLAGSRGSAALMFVDIDNFKYINDTMGHGFGDRLIVEASKKLLSIVGDHGVIYRFGGDEFIILLHSLTDKGEAGMMASRILAGLKEAVDIDNSLVHISTSVGISLYPDHGSDIMELVKRADIAMYKAKEAGKGNFIVFDNPLNDTFAERMNIEKQLYTAMERNEFDLYYQPQVDLALNKVTGLEALLRWNSPELGPVSPFKFIKVAEDSHLIIPLGSWVLRKACAFLKKLHEQGFEHLTMSINISMLQLLQTDFNEVVLDTLHSSGLEPDYLELEITESILIQSYEHVGTKLNELREKNIKIALDDFGTGYSSLSYLTHLPISTLKIDKSFIDSIPAETNQAILLEQMLMIGKRMNMCVIAEGVERAEQLAYLQEQGCDKIQGYLFSKPLAAKEVERLLAGWECSGLFFSKSTETC
>NZ_CP004078.1|WP_025336752.1|4796032_4796845_+|alpha/beta-hydrolase
MTDPIPNNHDSVSYHRKSFEGPDTVLSYIDFGGGGPPLVALHGHMNEGLFARHLAERFAREYRVIALDQRGHGESGRPASFDNDRYVADALALLDHLGIDHAVLLGHSLGGVVAYRLAARRPERVRALIIEDIGAAVDDDLGFAAEWPRRMPTREALIAVLGRLGPAFAYSMRQYEDGWGLPFVPEDMIRSQRKLNGNHWDDWLATDCPALLLHGMRSNCLSYGQAEEMARRRPNTKLVHLDAGHTIHFDAPDRYLEEIEQFLTETGAHS
>NZ_CP004078.1|WP_084266674.1|4813330_4814701_-|serine-protease
MLELLASLGNAALHMLMQPFYYIALLFIAFYYRRQTLLERKLIHVKMHSWGSEVWRAVWSGLAAGVLVSAAAVLLGVSVTGAAVVCIWVVSAVLVIFRVRYFCFAYSIGLLGILQFILSFFPDFQPGGLGGEAAAAIRGMDIPALLALAAILHLAEALLARWQGPALATPLFLEGKRGRVVGGYRMEAFWPLPLFLLVPAGAGAGDLPWQTLLGGGFGLVSLPVIIGFSQLTTGMLPQRKAARASGWLLLYGAVLLGLALAAAWYSPLTLPAALAALLLHEGLVWYGALEERRRSPYFVHPPHGLKVLAVLPGSPAHELGILPGEVLLKVNGEALTGRALQLHEALRRSPAFCKLEVQNAAGESKYLQRAIYDGDHHLLGVILAPQPDEDTTAPEKPAGILGIALMKTGARRRQSGGSELLPREAAAAQETAAAPAPAPGAAGVLPGPGGAESAKG
>NZ_CP004078.1|WP_025336762.1|4814980_4816447_-|S41-family-peptidase
MLKKSTAIFMVIAALLCGSLLTLAVTGSLLSGQAAGESLATAPSIGTGLKQSEAKKLGTTLGLIESNYYQNVDRTKLIDGAVNGMMEALGDPYSNYMAKETAEKFEESIEGSFTGIGAEVSSDNGKVVVVSPIKGSPAERAGVQAKDIIVSVNGQSLEGMDLNDAVAKIRGPKGSTAVLVIQRNGSAEPLTLRIVRDDVKLETVYSSMEQGGIGVIEITQFSLNTADRFKEELDKLEKKGLKGLVIDVRNDPGGVLPVVIDIAEQFVPNGKTIVQVENKEKQRELTTSKGSGKDYPVTVLMNKGSASASEILAGALQQSAGAKLIGENSFGKGTVQTSFDKQLGDGSLLKITIAKWLTPNGSWIHGKGIKPDIAVAQPDYFSVSPIDKSRPLQYNMNNADVKSAQTMLDGLGYKPGRKDGYFDAGTREAVRKFQSAAKLKATGIIDAKTADALEAALIKAIRKPANDNQRNRGIEEIRKEIGAKAAKS
>NZ_CP004078.1|WP_025336763.1|4816565_4817879_-|M23-family-metallopeptidase
MKKIAAGLAVLLLSAVMFQPSEGYAKKTSVAEIEKQLKALQQDVQDAKAQQEKASAQGQQAQHYKNKTNQNLQYVLGQIAQVKGEMTQISSKIASTEESLKTTAAELDAAQERVDSRQKLIESRVRLMYTDGAVSYLDVLLSSTSFSDFLDRADSLKLIVDQDQDLLDQHKRDEATVTAKKKELEGQYAQAKQLYGDLESQRSVLKEKEAEKQQLIAYYDKAIEDAEDISQEQNAKLVQLASQRAALEDQKDKIKAEEAARRAAAAKAEAARRAAAEAAKRAAAAASSGSSDDDHGGDDSGGTYASGSGPLLLPVGNARISSPYGYRIHPVTGERKLHTGVDFAVPQGTDIHAAESGTVIVAEWWSGYGYCVVIDHGGGMWTLYGHIREGGIKVSVGDKVERGQTIAESGATGRVTGPHLHFEVRIDGKPVEPMDYL
>NZ_CP004078.1|WP_025336764.1|4817926_4818841_-|ABC-transporter-permease
MSFKTFLRHVREGFKNVFRNGWMSVASITSIVVSLLVLGVFILLVLNVNSLADKADSQVQITVHLTLETKKALRDTLQNEIGNMPEVSKVEFISKEQGLAELRKDLGPDADSILEGFDKDNNPLNDAFRVEVVEPTTVPFVAKKIEALNDTHPEKPIYKVKYGQGAIETLFKITRTVRNIGFVFVAGLGLVSMFLISNTIRVTILARRKEIGIMKLVGATNAFIRWPFFVEGALIGLLGSLVTVGVLYAGYTGLNSSMKGDPLMGWNLLPFNDIWMQLCGLLIGLGILIGIWGSTVSIRKFLKV
>NZ_CP004078.1|WP_025336765.1|4818830_4819517_-|cell-division-ATP-binding-protein-FtsE
MIEMQDIWKTYPNGTHALQGVSVKIDRNEFVYVVGPSGAGKSTFMKLIYREETPTKGQISVGGFNIGKLKPRKIPYVRRNIGVVFQDFRLLPKLTAFENVAFAMEVIEAPKKQIKKRVNEVLDLVGLRSKANREPSQLSGGEQQRIAIARAIVNNPSVIVADEPTGNLDPETSWGIMQLLDEINFRGTTIVMATHNRDIVNKMRKRVLAIEHGQIVRDQLRGEYGYEF
>NZ_CP004078.1|WP_025336766.1|4819802_4821230_+|VanW-family-protein
MKKLHGVLIAFISLILAVSLVYGGLYLYAGQLSVPKGTSLAGWKVGGMKMAEARKELERKLQSLHTVPVTLTAGGEAKIRLTLKEAGVSYNADSFLSGLDRLTDGGLLDRVKARYGFRKVWSLQADWDSTLLKRSLSPQWESATFGDPVNATRRITESDGIVYTPGSTAQRVDWNGLEEAMRAALPGSFSQAEAARSTGIVIGLPLKTVQPDVTLDSLQEQGVTRKITEFSTSLGSSGPGRIYNVESAAKAVNDTLLPPGGIFDYGKAIEKAVSTTGFREAPVIVNGKLQPGVGGGICQVSSTLYNAALRTGLEIVERRNHSLPVSYLPKGQDATFAQGSINFRFRNNTGRYLLIRSEVRGRTLTVKFFGTFPQNVSYTVESKTVDILPPGSRTVPDASLPRGASRTLQRGKAGYVVETYLTRMVDGIAVERKRLSRDIYRPQKALVAVGQGSGGLFTPEPTERPLVEDGIRKVN
>NZ_CP004078.1|WP_025336767.1|4821480_4821900_+|hypothetical-protein
MMTTKTALTASKLAEIIRPVPVVLDRRTCRQALRTMFEHPESKCLVLCNAVGEPVGLLMSEKFLLAATGRGETDSFYKEPVMKLAHVRPLIVDISSAPRKVLAMALGRNPMDWNDAIIVTDGGKLAGVVYVSDLHALRP
>NZ_CP004078.1|WP_144240568.1|4821931_4822111_-|hypothetical-protein
MMAWNPGTINNLTATSIIPLVVMPREVLEEVSSQLGRFNITGRNAEEGKRGWGKSESLR
>NZ_CP004078.1|WP_025336768.1|4822220_4822886_-|type-4a-pilus-biogenesis-protein-PilO
MEQINKYRSPIVLGVLILFLMLLAFYLLGLQPASRKISEQEAQLAQLNEQNQLLQTQIDKLQSSSPGAEEEEALLAQLPRGDNSEQLILDLRAIGTMTSARLKDISFTAGNVNPIQEMTGASTAAYPTVKAFKMTAIVEGDYTSIRNWMKALQMLPRIINVDSFVFQRASAKNPGAAQTMNSILTATVSFTAYYEEADQGKDGDKNTWTQSGSDQTALAGQ
>NZ_CP004078.1|WP_025336769.1|4822869_4824501_-|pilus-assembly-protein-PilM
MLGLSTPAAGLAIEQTGIRYISLKNKKSWEVRKKRFLPLPQGMIVANQVAESEALLDLVKQWVKKEGLRGSRIALSIPPSQIIIRKMTIPSANDKQVGQLVKLEVETGLHLPFDNPVYDYVVTEVDEDQSHLLVFAAPRKPIQEYIDILEKAGLRVTSVEIAATALARSLSTGKGESFEETMLINMEQSMLDVYMFRSGNPVFIRTINLMDLSQSVPQDNAASVSDWYMAEAAASSEEAHKQLSPEQVVEITAEILRMLNFYQYSLHDGSTRIKNVLIAGAPDARRQLFEELHQSLTEQDVSMIGLEQLAASANVPDSGLNDYRVAVGAALRGSGFLTIDLYPREDREAMLFPYIATALAGIWLLGTIGTGIYYVAEQGRISNNIEQIQGAQDRGTMLQAELAKLNGDGGQLNRKAAVGEILKYKMNIVSVLNELASGLPQGSALRNINYTYRTSIDLTVKVPRMEDASIYLARLRQMSFTVDASIQKLTEGDTGAGPVSAALTKSYTAIYKVNLTPNKPKEDADGTNGQENQGEEAGSGTNQ

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Crispr_ID: NZ_CP004078_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP004078_9

5010254-5010345

TypeV-U3

Consensus_repeat	Method
AAAAGTTTTGACAGCATCTGCTTTCAGT	CRISPRCasFinder

1 spacers

c2c10_CAS-V-U3

The CRISPR arrays of NZ_CP004078_9

>merge|NZ_CP004078|9|5010254-5010345|CRISPRCasFinder
AAAAGTTTTGACAGCATCTGCTTTCAGTCTGTACTTCGCAAAACTTGCTTCGGAAGCGTAGACCAAAAGTTTTGACAGCATCTGCTTTCAGT

>NZ_CP004078|9|9|5010254-5010345|CRISPRCasFinder
AAAAGTTTTGACAGCATCTGCTTTCAGT	CTGTACTTCGCAAAACTTGCTTCGGAAGCGTAGACC
AAAAGTTTTGACAGCATCTGCTTTCAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP004078.1\|WP_025336929.1\|5017124_5018237_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173817
NZ_CP004078.1\|WP_025336933.1\|5021340_5022693_-\|IS200/IS605-family-accessory-protein-TnpB-related-protein	c2c10_CAS-V-U3	-	gnl\|CDD\|223747
NZ_CP004078.1\|WP_025336924.1\|5010441_5011206_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224007
NZ_CP004078.1\|WP_025336917.1\|5002469_5003456_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223787
NZ_CP004078.1\|WP_025336916.1\|5001313_5001937_-\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NZ_CP004078.1\|WP_193373935.1\|5003472_5004294_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NZ_CP004078.1\|WP_025336934.1\|5023202_5024057_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270315
NZ_CP004078.1\|WP_025336921.1\|5006138_5007830_-\|dihydroxy-acid-dehydratase	unknown	unknown	gnl\|CDD\|376416
NZ_CP004078.1\|WP_025336931.1\|5019614_5020028_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP004078.1\|WP_084266597.1\|5014449_5016366_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NZ_CP004078.1\|WP_025336919.1\|5004461_5005127_-\|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase	unknown	unknown	gnl\|CDD\|180618
NZ_CP004078.1\|WP_025336915.1\|5000368_5001277_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381312
NZ_CP004078.1\|WP_025336922.1\|5007993_5009271_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NZ_CP004078.1\|WP_025336923.1\|5009289_5010240_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|238571
NZ_CP004078.1\|WP_025336926.1\|5012611_5013115_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP004078.1\|WP_025336920.1\|5005185_5006151_-\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240649
NZ_CP004078.1\|WP_025336925.1\|5011438_5012497_-\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380506
NZ_CP004078.1\|WP_025336927.1\|5013252_5014113_-\|transglutaminase-family-protein	unknown	unknown	gnl\|CDD\|224224
NZ_CP004078.1\|WP_025336928.1\|5016362_5017112_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP004078.1\|WP_158442615.1\|4999575_4999749_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP004078.1\|WP_025336929.1\|5017124_5018237_-\|S8-family-serine-peptidase	gnl\|CDD\|173817	cd07492, Peptidases_S8_8, Peptidase S8 family domain, uncharacterized subfamily 8. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	3.88979e-36
NZ_CP004078.1\|WP_025336933.1\|5021340_5022693_-\|IS200/IS605-family-accessory-protein-TnpB-related-protein	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	8.69687e-10
NZ_CP004078.1\|WP_025336924.1\|5010441_5011206_-\|hypothetical-protein	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	0.00462883
NZ_CP004078.1\|WP_025336917.1\|5002469_5003456_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	2.13003e-30
NZ_CP004078.1\|WP_025336916.1\|5001313_5001937_-\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	2.54471e-27
NZ_CP004078.1\|WP_193373935.1\|5003472_5004294_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	1.66617e-66
NZ_CP004078.1\|WP_025336934.1\|5023202_5024057_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270315	cd13597, PBP2_lipoprotein_Tp32, The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold. This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.	5.9927e-112
NZ_CP004078.1\|WP_025336921.1\|5006138_5007830_-\|dihydroxy-acid-dehydratase	gnl\|CDD\|376416	pfam00920, ILVD_EDD, Dehydratase family.	0
NZ_CP004078.1\|WP_084266597.1\|5014449_5016366_-\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	4.33824e-05
NZ_CP004078.1\|WP_025336919.1\|5004461_5005127_-\|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase	gnl\|CDD\|180618	PRK06552, PRK06552, keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional.	4.25752e-102
NZ_CP004078.1\|WP_025336915.1\|5000368_5001277_-\|aldo/keto-reductase	gnl\|CDD\|381312	cd19086, AKR_AKR11C1, AKR11C family of aldo-keto reductase (AKR). Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.	2.23679e-116
NZ_CP004078.1\|WP_025336922.1\|5007993_5009271_-\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.95562e-90
NZ_CP004078.1\|WP_025336923.1\|5009289_5010240_-\|sugar-kinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	8.77582e-106
NZ_CP004078.1\|WP_025336926.1\|5012611_5013115_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	2.65833e-15
NZ_CP004078.1\|WP_025336920.1\|5005185_5006151_-\|phosphoglycerate-dehydrogenase	gnl\|CDD\|240649	cd12172, PGDH_like_2, Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.	1.3318e-150
NZ_CP004078.1\|WP_025336925.1\|5011438_5012497_-\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380506	cd06283, PBP1_RegR_EndR_KdgR-like, ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR. Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR, all of which are members of the LacI-GalR family of bacterial transcription regulators. RegR regulates bacterial competence and the expression of virulence factors, including hyaluronidase. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	2.13603e-110
NZ_CP004078.1\|WP_025336927.1\|5013252_5014113_-\|transglutaminase-family-protein	gnl\|CDD\|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	3.99321e-44
NZ_CP004078.1\|WP_025336928.1\|5016362_5017112_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	2.16318e-96

>NZ_CP004078.1|WP_025336923.1|5009289_5010240_-|sugar-kinase
MKSCDVVTFGEAMAMFIADRPGELHQIEKFTKALAGAETNVSIGLARLGFGMRWISKIGNDAFGKFIVEALRKENVDVDAVFVDDRYPTGFQMKSKVLDGDPQVQYFRKGSAASTICPGDVDMSFFTSAKHLHLTGIPAAISSCARELSFEAIKAMRAEGRSISFDVNLRPKLWGSEAEMIETVNALAVQADWVLPGMGEGKLLTGYSNHRDIAAYYLDRGVQLVAVKLGPEGAYYRTPTEEGIVEGFKVQAVDTVGAGDGFAVGLISGLLDGLSVSEAVRRGNAIGALAVTAEGDSEGLPTRGQLSAFMEASVII
>NZ_CP004078.1|WP_025336922.1|5007993_5009271_-|MFS-transporter
MENKLLAPSRWLKLIPVIFFTYSLAYLDRANYSFGSASGMADDLHITPSASSLLGALFFLGYFFFQIPGATYAAKRSAKKLVFFCLILWGSCAAATGLVNDIRVLYVIRFTLGVVESAVMPAMLVFLSNWFTKSERSRANTFLILGNPVTVLWMSIVSGYLVHGLGWRHMFIIEGLPSVIWAFFWWKLVKDKPAEAKWLSDAEKKDLEQALLEEQKGMKEVKNYREAFKNPKVIMLSIQYFFWSIGVYGFVMWLPSIIKESSGMGIVNAGWLSSVPYLAAIIGMLGVSYYADRTMNRKGAVWVCLLVGAIAFYGSYLIGASNFWLSYSLLVIAGGAMYAPYGPFFAIIPELLPKNVSGGAMALINSFGALGSFAGSYVVGYLNGSTGSPDASFIFMSLALVVSVVMTIVVKTPKGNAPDGEKLAA
>NZ_CP004078.1|WP_025336921.1|5006138_5007830_-|dihydroxy-acid-dehydratase
MSNRISTISPFTRAILKAHLCSCGVDYSKMDKPVIAVANSWNEIVPGHVHLRQLADRVKAGIEAAGGLALEFNTIAVCDGIAQGHEGMKYSLPSREIVADSVETMVKAHGIFDGMVVLSSCDKIVPGMLMAAARLNLPGLVVLGGVMPNHIKPKESKAARRAFLDGKLDEKGLVEVTNQYYPGPGACPFLGTANTMQGLSEALGMAMPNTSWMQALSDEQLDAAEAAGRQAVELVKKGITPSQIMTREAFENAISVLLAMGGSLNACLHLPAIAHELGIELPMTLFDDISRRVPFLAGVTPNNQEYTTNDLQRAGGMKALMKELGGLLHTGALTVTGDIVENNIADAEVLDRDVIRTLEEPLDKEGGVAVLVGNLAADGALIKQSAVAPELRSFTGPAKVFNSEEAFSDAYEAGLIEEGDAVVIRYEGPKGGPGMRELHRCTEILGKFKRAALVTDGRFSGATSGLSIGYASPEAAEGGTIALVQDGDLIEIDIATRKLQLHVSDEELAKRAKHLEEFKVEASKLLRLYAQHASSASKGGVRVVSEGNSESQVSKEEVTVCQK
>NZ_CP004078.1|WP_025336920.1|5005185_5006151_-|phosphoglycerate-dehydrogenase
MPKVVALPRSFSRSEEAKEMLLQAGFEVIWNTEGRPLKEAELIEVIKGADALITGIDEVTAKVLEAGAPTLKVVAKYGVGYDNIDVEAANRLGIPVTITPGAPTRSVAELALTLMLSVSRHIPQMNVGVRDGGWNRITGTELGDKVLGVVGLGAIGAEVVKRAVAFDMKVIAYDAFVRQDMIDKYGVQYVTLEELYAQSDYITLHAPALPETVGMINKESLAQMKKSAILINTARGDLVVEQDLYEALSSGQIAGAGLDTFVQEPPATLDIVGLPNVVTSPHVGSNTVEAGYRMAKMAAEEAIRAVNGEAPKFPVKVPVNK
>NZ_CP004078.1|WP_025336919.1|5004461_5005127_-|bifunctional-2-keto-4-hydroxyglutarate-aldolase/2-keto-3-deoxy-6-phosphogluconate-aldolase
MKKLRIINQIHEGGVVAVLRGDSPEEVVEMAKQSIAGGIKIIEVTLTVPFALRAIEKLAAEYSSSAPADSDKYAVIGAGTVLDPETARAAILSGSEFIVGPSLNPETVKLCNRYRVPIMPGVMTAKEIQEALDLGVDVVKLFPGNLYSPSMIKAFKGPLPQANVMPTGGVNLENLKDWIKAGAFAVGIGSDLTTDAIREKDYSLVAKKSAQYIEAFKAAIK
>NZ_CP004078.1|WP_193373935.1|5003472_5004294_+|ABC-transporter-permease
MYYYYGGDFAVVKVLRSIWNSIYKLLSIILFLALWEIIARLHLVNTVFFPPFTKVVVALWQLTVSGVLVENLFISLRRSLTGFILGLAFSIPLGLLIGWYRGFERFIDPLFQTFRNLSVLALLPIFILFFGIGETSRVAVIFWAVLWAVLLNTIAGVKSTDLSLIKAARSMGISKLSLFTKVVLPGALPSIFTGIRLSATTSVLVLIAAEMLGANTGLGYQLYFFQANVKPPETFAIVIVLALLGLAVNYSLAALEKRTFRYREELPDTGKTF
>NZ_CP004078.1|WP_025336917.1|5002469_5003456_+|ABC-transporter-substrate-binding-protein
MIRRFAFVLLISVLLIISAGCGNDNSAASGKPDSDGLFPIRVATQTGFNEITIADELGYFKEEGIKIEDTGVLGKGVTEYQLIAQGINDAFISGHPPNVAQARLAGLKMLAVAPGMVDNKDFPHVRYLVQDSSPIHSLNDIIGKKVAISNVAPCTDGYLKYYLSQQHLSGDINWTTLPSPGQQEQSLEQGLVDVTTSHPPFAGIALKQKGIRQIATSWDILHSPGAGLSVRGFSEDFIKQHPDVVKGFTRALAKVRPWINSHQEEAKRIVAKQLKLEPEDLSVFWYDEDKDINQDYIKQWFDISEQIGLWKKGDIQPADIFTNEYAPQ
>NZ_CP004078.1|WP_025336916.1|5001313_5001937_-|TVP38/TMEM64-family-protein
MYALDVISWLTEENLRGMLERYRSLGPFPGIVLTFMKSFVPPLPTLLIVGLNAAVYGLWPGFLYSWIGLVAGCLATFLIIRKIASQRFLRKWAQRPKVARGMEWVRRSGFSYVFLLSLFPVGPFVVINLAAGLAGMRLRSYLLALAAGKAIMVFAVSYIGSDAGRFIRNPAEVLYVLLFVLLSLWGVKSIEGYFSRLSHSGGRRRKP
>NZ_CP004078.1|WP_025336915.1|5000368_5001277_-|aldo/keto-reductase
MKYRKLGSTGLNVSVIGVGTWQFGGEWGKDFTQDEVDAMLDKAGELGINLIDTAECYGDHLSEKFIGSYLSRRKREDWIVATKFGHHFSGHLKREQLWSADNVLKQLDDSLRALQTEYIDLYQFHSGTDADFDNDKLWNMLDAQKRAGKIRHLGVSISTANDGVHQTSSAPEIGAEAIQVVYNRLERQPEEKLFPLCKEHNLGVLARVPLASGYLSGKYKADAVFQAGDVRANHDAKKREEQLRLVAEIAANEVPAGLNMAQWALGWCLQHPAVTSVIPGCKNVEQVVSNAQAADLDIVAKG
>NZ_CP004078.1|WP_158442615.1|4999575_4999749_+|hypothetical-protein
MLCRWPGGGERQGLAAGGKATADAGPAARAEHQQGADAVQVLRQEGRPSAYAACGAA
>NZ_CP004078.1|WP_025336924.1|5010441_5011206_-|hypothetical-protein
MTQVFTTTASLGPLAADGGQELCVPVAIAAGCAGIEIRRELFREETPRLDDLSDLIRKGQLVSVYSAPIELWKADGSLNVEKLDVVIPEALSIGAVWLKTSLGHYKSGVSDLEGLKKYWNSLVSDSDALELTVENDQTLHGGNVAKLRKFFEDCQEAGLFIQMTFDIGNWNFTEEEAMKAAAELNKYVGYIHLKHVEKIDGKLVTLGLPEDKDSLWRSILDLLPRDVPRTIEFPVEGEDVEGVLRKYVSMISEA
>NZ_CP004078.1|WP_025336925.1|5011438_5012497_-|LacI-family-DNA-binding-transcriptional-regulator
MDSINQPPRPPQKATIADVAKAAGVSKTTISRYLSGDYKSISDATLQRIKQSVKELRYRPSRLARGLRQDRSYSIGMIFADISNPFSTSVLKGAEDVCTKQGYSMIVCNTDNDPEKEKNYIAMMHAQRVDGLIIHPTGQNLENLRELSEDQIPIVLIDRRIPGLKVDTVGTDNEQAMIEATGHFLDQGFERIGFFSQPIQRVSSRIERAQTFVRILSAAGHPSVDDIYEYEPRIQGQFDEQLDRFIAETQGQYRMIFAVNVVTQLKLINALQKRGLRIPEDVGFAGVDDSEWAPVVGSGLTTIAQPTFEIGNKAMERILERIAGDNGPEQHFALSANLITRGSTPSRNAKIL
>NZ_CP004078.1|WP_025336926.1|5012611_5013115_+|GNAT-family-N-acetyltransferase
MRIHSNILSLRKTEEKDLEFVLAAERSEDNRPFIGQWTAEQHRAALHDAGMLHLVIETDMGEPAGYVIVTGLQNANLSVCIQRIVIERKGRGYGKEMLPLLIRWLFRSTPVHRLWLDVREHNVRARHLYETVGFVYEGTLRDCVMTENGFESEHILSILRPEYEAGR
>NZ_CP004078.1|WP_025336927.1|5013252_5014113_-|transglutaminase-family-protein
MNYEIVHTNTFTYETQVDQSLNTIRLKPLTDEVQRLLMYRAEITPASLTQEYTDLWGNQVETFFIPEKHNLLEVKTTSVVSIQRGSFIYEIQYSKRMQDIFHSQQFRQHYLSFLNETDYTLLLPEQLSEVNRGLGEMDNPVQYALRVMRYVYETFTYCGEVTSVNTLARQAFELKKGVCQDLAHVMIGILRACRIPARYVSGYLYVGEDSALKGDAATHAWVEVMVPGIGWVGLDPTNNVEALDNHIRVGTGRDYADVSPLQGVYRGGSSTLDVGVSVTLLEHPGE
>NZ_CP004078.1|WP_084266597.1|5014449_5016366_-|FtsX-like-permease-family-protein
MKTIAFKMFRANMQQYRLFILCNLASVAISYSFIAIAANKPFKDPTIVDSMVSSNIYAPTALVVLFSCLFIPYTHSVFMKVRSKEYGILLTLGMTESEARIQVLIENMVLCVLFLLSGLGVGTLLSLFFWGMIRYGIGIHGIQIKVSLVAYKVTALYVGGVFLLSLAFNLLSMLKSTILEKIKYTDKTESGGRAKVWLCAAGVGLTVASFAVMVLFYHIHSNIWFVSLLVCVLGSVLIFFNGGALIDYYKLKRPQSYLRQLFLLSDIKYYYRKNRTIFFVTSWIFFAILFFMMFSLITYPNFTHNAVTYHPYHMVYTEITGSYRPLGDKDVRQIAESHGNRVIREDSVKFVRNELYTIFDVADIDKLLAKRYSVQRGSVLYVYPYDVKDGYEHVTDGKLADLRIDSPEGARSFSIQDSVMDPLFGQINSISDRILLVNTQDYSWFTTHSDSYKIGGFLHAYNFADWRHSKDIVEEVAKKLHKQNGGDPLDRFYQVSSRTAAYRTAHQSSNFLTFVVLYACLLLYFSAIAMIHFKLKMESMSDNRRYRSLHRIGLLEDELKTMVDRKIRVIFGVPFAYAAVLTIAYSYYTNSSYGYGLIGLACGALTVSAFLLLHAAVYRRYSQSSSRQATAGISQFKG
>NZ_CP004078.1|WP_025336928.1|5016362_5017112_-|ABC-transporter-ATP-binding-protein
MNALEMRQVSKKYWIHTNRNTMVLNNIDIVLGKNEFVGIMGTSGSGKTTLLNVASGIDKCDGGDIFIGGQNICAMKKNELSLFRRNHIGMVFQDFNLLSSLTVRENIMVPLILDKNTEKLEGDDVERLAKMLDIGSILDQYPYEISGGQQQRAAICRAIINDPEILFADEPTGNLDSQSSKRVLSYFELIHQTREASILMVTHDPFSARHCQRVIFLQDGSVLGEISRQSSDKESFMNRILDVLQRGHI
>NZ_CP004078.1|WP_025336929.1|5017124_5018237_-|S8-family-serine-peptidase
MNVALIDNGVAINNYTRKYVSSFLEMNESFMEFVEQTSHVDPASHGSVCAGIIRNSTDRVNLHSLKILDKNLSASAAKLIKALEWCQKNRIDIINLSLGTTNSKDFIEIRRCIKQLVSNGIIIVAAINNRGTYTIPASMPEVIGVCSHNSDDIKIIEDSIIGIDVAACSNHWISLDYDKGIHTPYCNSFAVPAVTGLLCQWLGRRESNNEVHFAETLEKVVRSKQQSVAGFSDESMVKLSLTSKIFRDFADAKIRKKVPLIEISCKNEDLSELNRLFYNDNLFPVALSGDTSIENFKKKKLYHIIQSLSSFFDCDLFFLHYLPTQLSRKDIFLRVDESGIHLTCKRRFQKLEMSLQSLKEAYQTILDLLT
>NZ_CP004078.1|WP_025336931.1|5019614_5020028_+|hypothetical-protein
MCYEQREGKRVYLGTRAWTDKKLKRPIRAVYHVIERTMEADGQLLLTPRIEAQVFFTTLTCSPWQVLQLYGDHATSEQFHSELKTDLNLECLPSRTFATNDLVQYAGLIAYSLLRAIGQISLQEPDAPVRMRCITDG
>NZ_CP004078.1|WP_025336933.1|5021340_5022693_-|IS200/IS605-family-accessory-protein-TnpB-related-protein
MKVVKTLKHPITSHHRMLDATLHVYQEALSFLITVIQEQFMALKSLSTQAVVTAVERLTHRTRHNPDPLYTEFDQRFYKFPSYFRRSAIAEAFGIVKSHHSRFELWQAERQHAQQEGKRFSKKPPILQAQHQAFPCLYKGNMFIRTSHTTANIKVFHQGDWVWLPITFKGQDLFKRNVWSMKECSPTLVRTGKRYALHIAYEGDVKLTQTEPSKQRVCAVDLGLTNSAVCSVMDASGTVLARTFINQAKEKDRMRQITGKLKQAQRQSGIGTKPNFWRRINGLQTHIVHDTAHQILAFAQKHRADVIVMEYLGKMRLPKGTWGAKRFRAKLQFWAKRCIQTKVTEMAHFLGMRVSMVNPANTSALAFDGSGFVQRNTKRDVAVFTTGKMYHADLNASYNIGARYVLRNIQKSTSEMRWLSLEAKDPSLAKRTYWTLASLIRVQQALRLQT
>NZ_CP004078.1|WP_025336934.1|5023202_5024057_-|ABC-transporter-substrate-binding-protein
MARKRNIWFAAVIVATGILAGCGSQNGNGEAAAPQASTAASEAPKEVTIKVGASAVPHAEILEFIKPKLKEEGVNLEVVTLDDDGQLNPALQEKQIDANYFQHVPYLDSVKGEKGYDFVVTAKVHVEPIGFYSEKLKSKDEIPHGAKIGIPNNPSNEYRALVLLQQQGFIKLKDGITTYEATPKDIVDNPHNLEFVEADAATLPRSLPDLDGAIINTNLVLEAKIDPKSALFREDANSPYANVVVVRKGDENREEIKKLDEALTSPEVKKFIEDKYGVAVVPAF

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	900668-900725	6	0.897
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	1553592-1553649	7	0.879
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	2547776-2547833	7	0.879
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP054613	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence	1583788-1583845	8	0.862
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP016544	Planococcus donghaensis strain DSM 22276 plasmid pPD76, complete sequence	7380-7437	9	0.845
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP033045	Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence	484370-484427	10	0.828
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP033045	Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence	485380-485437	10	0.828
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	CP031730	Stenotrophomonas rhizophila strain GA1 plasmid unnamed1, complete sequence	312640-312697	10	0.828
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NC_004604	Bacillus megaterium QM B1551 plasmid pBM400, complete sequence	47657-47714	15	0.741
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP041068	Bacillus megaterium strain KNU-01 plasmid pKNU_01_4, complete sequence	37432-37489	15	0.741
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	CP041516	Bacillus aryabhattai strain KNU10 plasmid unnamed, complete sequence	16631-16688	15	0.741
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP024037	Bacillus aryabhattai strain K13 plasmid unnamed2	9191-9248	16	0.724
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP026740	Bacillus megaterium strain YC4-R4 plasmid unnamed4	69536-69593	16	0.724
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP010587	Bacillus megaterium Q3 plasmid p1, complete sequence	2068-2125	16	0.724
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NZ_CP023319	Bacillus megaterium strain A plasmid p2, complete sequence	553-610	16	0.724
NZ_CP004078_1	1.1\|134166\|58\|NZ_CP004078\|CRISPRCasFinder	134166-134223	58	NC_017139	Bacillus megaterium WSH-002 plasmid WSH-002_p1, complete sequence	90-147	16	0.724

1. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.897

-gctaccatacatacggaggcttagctcagctgggagagcatctgccttacaagcagag	CRISPR spacer
aagtcgcttaca-acggaggcttagctcagctgggagagcatctgccttacaagcagag	Protospacer
 . *  * **** **********************************************

2. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 7, identity: 0.879

---gctaccatacatacggaggcttagctcagctgggagagcatctgccttacaagcaga	CRISPR spacer
cgggtcaccat---tatggaggcttagctcagctgggagagcatctgccttacaagcaga	Protospacer
   *..*****   **.*******************************************

3. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 7, identity: 0.879

---gctaccatacatacggaggcttagctcagctgggagagcatctgccttacaagcaga	CRISPR spacer
cgggtcaccat---tatggaggcttagctcagctgggagagcatctgccttacaagcaga	Protospacer
   *..*****   **.*******************************************

4. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP054613 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.862

---gctaccatacatacggaggcttagctcagctgggagagcatctgccttacaagcaga	CRISPR spacer
cgggtcaccat---catggaggcttagctcagctgggagagcatctgccttacaagcaga	Protospacer
   *..*****   .*.*******************************************

5. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP016544 (Planococcus donghaensis strain DSM 22276 plasmid pPD76, complete sequence) position: , mismatch: 9, identity: 0.845

---gctaccatacatacggaggcttagctcagctgggagagcatctgccttacaagcaga	CRISPR spacer
ggggtcaccat---tttggaggattagctcagctgggagagcatctgccttacaagcaga	Protospacer
   *..*****   * .***** *************************************

6. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP033045 (Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.828

----gctaccatacatacggaggcttagctcagctgggagagcatctgccttacaagcag	CRISPR spacer
aggggtcac----catatggaggattagctcagctgggagagcatctgccttacaagcag	Protospacer
    *..**    ****.***** ************************************

7. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP033045 (Bacillus foraminis strain Bac44 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.828

gctaccatacatacggaggcttagctcagctgggagagcatctgccttacaagcagag	CRISPR spacer
ggggtcaccaaaatggaggattagctcagctgggagagcatctgccttacaagcagag	Protospacer
*  ..**.  * *.***** **************************************

8. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to CP031730 (Stenotrophomonas rhizophila strain GA1 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.828

gctaccatacatacggaggcttagctcagctgggagagcatctgccttacaagcagag	CRISPR spacer
acacctgtttctatggaggattagctcagctgggagagcatctgccttacaagcagag	Protospacer
.*  *..* . **.***** **************************************

9. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NC_004604 (Bacillus megaterium QM B1551 plasmid pBM400, complete sequence) position: , mismatch: 15, identity: 0.741

gctaccataca------tacggaggcttagctcagctgggagagcatctgccttacaagc	CRISPR spacer
------atatagatttttttggaggattagctcagctgggagagcacctgccttacaagc	Protospacer
      ***.*      * .***** ********************.*************

10. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP041068 (Bacillus megaterium strain KNU-01 plasmid pKNU_01_4, complete sequence) position: , mismatch: 15, identity: 0.741

gctaccataca------tacggaggcttagctcagctgggagagcatctgccttacaagc	CRISPR spacer
------atatagatttttttggaggattagctcagctgggagagcacctgccttacaagc	Protospacer
      ***.*      * .***** ********************.*************

11. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to CP041516 (Bacillus aryabhattai strain KNU10 plasmid unnamed, complete sequence) position: , mismatch: 15, identity: 0.741

gctaccataca------tacggaggcttagctcagctgggagagcatctgccttacaagc	CRISPR spacer
------atatagatttttttggaggattagctcagctgggagagcacctgccttacaagc	Protospacer
      ***.*      * .***** ********************.*************

12. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP024037 (Bacillus aryabhattai strain K13 plasmid unnamed2) position: , mismatch: 16, identity: 0.724

gctaccatacata-------cggaggcttagctcagctgggagagcatctgccttacaag	CRISPR spacer
-------tatatagattctttggaggattagctcagctgggagagcacctgccttacaag	Protospacer
       **.***       .***** ********************.************

13. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP026740 (Bacillus megaterium strain YC4-R4 plasmid unnamed4) position: , mismatch: 16, identity: 0.724

gctaccatacata-------cggaggcttagctcagctgggagagcatctgccttacaag	CRISPR spacer
-------tatatagattctttggaggattagctcagctgggagagcacctgccttacaag	Protospacer
       **.***       .***** ********************.************

14. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP010587 (Bacillus megaterium Q3 plasmid p1, complete sequence) position: , mismatch: 16, identity: 0.724

gctaccatacata-------cggaggcttagctcagctgggagagcatctgccttacaag	CRISPR spacer
-------tatatagattctttggaggattagctcagctgggagagcacctgccttacaag	Protospacer
       **.***       .***** ********************.************

15. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NZ_CP023319 (Bacillus megaterium strain A plasmid p2, complete sequence) position: , mismatch: 16, identity: 0.724

gctaccatacata-------cggaggcttagctcagctgggagagcatctgccttacaag	CRISPR spacer
-------tatatagattctttggaggattagctcagctgggagagcacctgccttacaag	Protospacer
       **.***       .***** ********************.************

16. spacer 1.1|134166|58|NZ_CP004078|CRISPRCasFinder matches to NC_017139 (Bacillus megaterium WSH-002 plasmid WSH-002_p1, complete sequence) position: , mismatch: 16, identity: 0.724

gctaccatacata-------cggaggcttagctcagctgggagagcatctgccttacaag	CRISPR spacer
-------tatatagattctttggaggattagctcagctgggagagcacctgccttacaag	Protospacer
       **.***       .***** ********************.************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

405562 : 414454

Bacillus_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025332900.1\|405562_406240_+	response regulator transcription factor	W8CYM9	Bacillus_phage	4.4e-58	50.2
WP_025332901.1\|406232_407555_+	HAMP domain-containing sensor histidine kinase	W8CYF6	Bacillus_phage	6.6e-66	47.9
WP_025332902.1\|407642_408674_-	ribonucleotide-diphosphate reductase subunit beta	A0A127AVZ3	Bacillus_phage	5.3e-87	45.5
WP_025332903.1\|408915_411249_-	ribonucleoside-diphosphate reductase subunit alpha	A0A0Y0AS84	Bacillus_phage	9.9e-259	62.1
WP_158442547.1\|411698_411860_-	hypothetical protein	NA	NA	NA	NA
WP_025332904.1\|411953_412472_-	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A1B1IXI7	Citrobacter_phage	6.6e-30	41.4
WP_025332905.1\|412468_414454_-	anaerobic ribonucleoside triphosphate reductase	A0A2R2ZH54	Clostridioides_phage	2.3e-131	40.0

DBSCAN-SWA_2

677469 : 688469

Mollivirus(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025333140.1\|677469_678765_+	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	7.4e-22	26.9
WP_025333141.1\|678792_679686_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	1.1e-43	34.2
WP_025333142.1\|679769_680015_+	phosphoribosylformylglycinamidine synthase subunit PurS	A0A0E3FJ99	Synechococcus_phage	2.6e-08	40.3
WP_025333143.1\|680020_680710_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_025333144.1\|680687_682934_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	3.1e-164	43.7
WP_025333145.1\|682918_684415_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.6e-52	34.0
WP_025333146.1\|684988_686032_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	7.2e-68	44.6
WP_025333147.1\|686031_686646_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.8e-24	35.4
WP_025333148.1\|686921_688469_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	4.3e-77	52.0

DBSCAN-SWA_3

1323617 : 1338528

Paenibacillus_phage(33.33%)

integrase

attL 1322216:1322230|attR 1333913:1333927

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1322216:1322230	attL	NA	NA	NA	NA
WP_025333671.1\|1323617_1324745_+	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	6.5e-22	29.1
WP_025333672.1\|1324787_1325687_+	formyltetrahydrofolate deformylase	NA	NA	NA	NA
WP_025333673.1\|1325814_1327035_-\|integrase	site-specific integrase	A0A0C5AN64	Paenibacillus_phage	1.3e-132	57.4
WP_158442558.1\|1327147_1328287_-	trypsin-like peptidase domain-containing protein	A0A1B1IRD3	uncultured_Mediterranean_phage	3.5e-07	32.0
WP_025333674.1\|1328452_1328788_+	hypothetical protein	NA	NA	NA	NA
WP_025333675.1\|1329040_1329253_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_025333676.1\|1329495_1329882_-	helix-turn-helix domain-containing protein	A0A0A8WFG2	Clostridium_phage	1.9e-10	40.0
WP_025333677.1\|1330003_1330267_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_025333678.1\|1330279_1330999_+	phage antirepressor KilAC domain-containing protein	R9VWW9	Paenibacillus_phage	7.7e-69	57.0
WP_025333679.1\|1331097_1331364_+	DNA-binding protein	A0A0C5AN65	Paenibacillus_phage	2.3e-10	49.3
WP_025333680.1\|1331377_1331611_+	hypothetical protein	NA	NA	NA	NA
WP_025333681.1\|1331600_1331789_+	hypothetical protein	NA	NA	NA	NA
WP_158442559.1\|1331835_1331994_+	hypothetical protein	NA	NA	NA	NA
WP_158442560.1\|1331981_1332173_+	hypothetical protein	NA	NA	NA	NA
WP_158442561.1\|1332219_1332387_+	hypothetical protein	NA	NA	NA	NA
WP_025333683.1\|1332376_1332706_+	hypothetical protein	NA	NA	NA	NA
WP_158442562.1\|1332692_1332863_+	hypothetical protein	NA	NA	NA	NA
WP_158442563.1\|1332900_1333047_+	hypothetical protein	NA	NA	NA	NA
WP_084266634.1\|1333285_1333891_+	ERF family protein	A0A0K2CNN6	Brevibacillus_phage	7.4e-57	59.7
WP_025333686.1\|1333891_1334302_+	single-stranded DNA-binding protein	A0A0K2CNI9	Brevibacillus_phage	2.1e-26	46.3
1333913:1333927	attR	NA	NA	NA	NA
WP_025333687.1\|1334314_1334698_+	hypothetical protein	A0A0K2CYI4	Paenibacillus_phage	9.2e-21	39.8
WP_051529729.1\|1334700_1335117_+	hypothetical protein	NA	NA	NA	NA
WP_025333689.1\|1335309_1335528_+	zinc-finger domain-containing protein	NA	NA	NA	NA
WP_025333690.1\|1335524_1335749_+	DUF3310 domain-containing protein	A0A291LBF7	Klebsiella_phage	5.4e-21	63.9
WP_025333691.1\|1335745_1335940_+	hypothetical protein	NA	NA	NA	NA
WP_025333692.1\|1335936_1336155_-	helix-turn-helix transcriptional regulator	A0A0K2CNL9	Brevibacillus_phage	1.6e-09	46.9
WP_158442564.1\|1336292_1336442_+	hypothetical protein	NA	NA	NA	NA
WP_025333693.1\|1336445_1337261_+	DUF4373 domain-containing protein	NA	NA	NA	NA
WP_025333694.1\|1337226_1338528_+	AAA family ATPase	A0A2H4J268	uncultured_Caudovirales_phage	7.1e-89	40.9

DBSCAN-SWA_4

3501090 : 3510855

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025335628.1\|3501090_3502299_-	D-alanyl-D-alanine carboxypeptidase	A0A1P8VVG5	Erythrobacter_phage	4.8e-07	33.3
WP_025335629.1\|3502610_3503102_-	GerW family sporulation protein	NA	NA	NA	NA
WP_025335630.1\|3503193_3503907_-	DUF2953 domain-containing protein	NA	NA	NA	NA
WP_025335631.1\|3504103_3504709_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	1.2e-14	33.7
WP_025335632.1\|3504677_3505469_-	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	3.7e-08	36.9
WP_025335633.1\|3505813_3506278_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.5e-44	58.7
WP_025335634.1\|3506358_3507612_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	7.5e-120	53.5
WP_025335635.1\|3507648_3508326_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	3.3e-37	42.3
WP_025335636.1\|3508344_3509445_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	2.4e-53	35.6
WP_025335637.1\|3509982_3510855_-	AraC family transcriptional regulator	A0A1B0RXG1	Streptococcus_phage	8.3e-25	42.1

DBSCAN-SWA_5

3930041 : 3941075

Tupanvirus(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025335998.1\|3930041_3931304_-\|tRNA	histidine--tRNA ligase	A0A2K9L0H9	Tupanvirus	1.3e-18	26.5
WP_025335999.1\|3932058_3932490_-	hypothetical protein	NA	NA	NA	NA
WP_025336000.1\|3932524_3933049_-	type 1 glutamine amidotransferase	A0A0N7KVR4	Yellowstone_lake_phycodnavirus	2.2e-20	39.4
WP_158442602.1\|3933158_3933311_-	hypothetical protein	NA	NA	NA	NA
WP_025336001.1\|3933478_3933922_-\|tRNA	D-tyrosyl-tRNA(Tyr) deacylase	NA	NA	NA	NA
WP_025336002.1\|3933941_3936119_-	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	J9Q7H7	Salmonella_phage	3.1e-12	40.9
WP_025336003.1\|3936428_3937745_+	uracil permease	Q9KX94	Enterobacteria_phage	5.7e-70	39.4
WP_025336004.1\|3937992_3938511_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.8e-26	43.0
WP_025336005.1\|3938663_3941075_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	7.2e-87	34.4

DBSCAN-SWA_6

4428270 : 4474044

uncultured_Caudovirales_phage(33.33%)

tail,terminase,portal,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025335161.1\|4428270_4429449_-\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	1.7e-33	31.3
WP_025336420.1\|4429716_4430961_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_025336421.1\|4431006_4432578_-	response regulator	NA	NA	NA	NA
WP_025336422.1\|4432604_4434395_-	sensor histidine kinase	NA	NA	NA	NA
WP_051529797.1\|4434484_4436284_-	glycoside hydrolase family 66 protein	G4U401	Lactobacillus_phage	3.6e-59	28.9
WP_144240631.1\|4436947_4439470_+	DUF4968 domain-containing protein	NA	NA	NA	NA
WP_158442610.1\|4439600_4440437_+	hypothetical protein	NA	NA	NA	NA
WP_025336426.1\|4440479_4442051_+	alpha-glucosidase C-terminal domain-containing protein	NA	NA	NA	NA
WP_025336427.1\|4442158_4443049_-	nitrogenase iron protein	NA	NA	NA	NA
WP_025336428.1\|4443123_4443591_-	hypothetical protein	NA	NA	NA	NA
WP_025336429.1\|4443860_4445156_-	hypothetical protein	NA	NA	NA	NA
WP_025336430.1\|4445159_4446506_-	hypothetical protein	NA	NA	NA	NA
WP_025336431.1\|4446996_4447362_+	hypothetical protein	NA	NA	NA	NA
WP_025336432.1\|4447559_4448192_+	hypothetical protein	A0A218KCL9	Bacillus_phage	6.6e-08	50.8
WP_025336433.1\|4448303_4449230_+	hypothetical protein	NA	NA	NA	NA
WP_025336434.1\|4449304_4449487_-	hypothetical protein	NA	NA	NA	NA
WP_025336435.1\|4449491_4450289_-	M15 family metallopeptidase	A0A127AWA8	Bacillus_phage	7.8e-38	64.1
WP_025336436.1\|4450290_4450602_-	hypothetical protein	NA	NA	NA	NA
WP_025336437.1\|4450601_4450808_-	hypothetical protein	NA	NA	NA	NA
WP_038597487.1\|4450828_4452985_-\|tail	phage tail protein	NA	NA	NA	NA
WP_025336439.1\|4453008_4453530_-\|tail	phage tail family protein	NA	NA	NA	NA
WP_025336440.1\|4453642_4455535_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_025336441.1\|4455556_4455955_-	hypothetical protein	H6BJ44	Methylophilales_phage	5.8e-26	49.1
WP_025336442.1\|4456034_4456580_-\|tail	phage tail family protein	NA	NA	NA	NA
WP_144240557.1\|4456576_4457329_-	hypothetical protein	E0YIZ1	Lactococcus_phage	4.0e-44	38.3
WP_025336444.1\|4457800_4462093_-\|tail	phage tail tape measure protein	Q9G097	Lactococcus_phage	2.5e-66	38.8
WP_025336445.1\|4462129_4462354_-	hypothetical protein	NA	NA	NA	NA
WP_025336446.1\|4462431_4462875_-	hypothetical protein	NA	NA	NA	NA
WP_025336447.1\|4462931_4463462_-	hypothetical protein	NA	NA	NA	NA
WP_025336448.1\|4463527_4463908_-	hypothetical protein	NA	NA	NA	NA
WP_025336449.1\|4463876_4464308_-	hypothetical protein	A0A0N9SJT1	Paenibacillus_phage	7.4e-11	40.5
WP_025336450.1\|4464307_4464628_-	hypothetical protein	NA	NA	NA	NA
WP_025336451.1\|4464642_4465041_-	hypothetical protein	NA	NA	NA	NA
WP_025336452.1\|4465056_4465275_-	hypothetical protein	NA	NA	NA	NA
WP_025336453.1\|4465292_4466381_-	DUF5309 family protein	A0A2H4J2M3	uncultured_Caudovirales_phage	4.7e-118	62.9
WP_193373907.1\|4466477_4467179_-	scaffolding protein	A0A2H4IZP8	uncultured_Caudovirales_phage	3.3e-24	49.4
WP_025336455.1\|4467272_4468430_-	hypothetical protein	NA	NA	NA	NA
WP_025336456.1\|4468386_4469268_-	type IV secretion protein Rhs	A0A0N9SJR1	Paenibacillus_phage	2.3e-67	50.6
WP_051529887.1\|4469267_4470668_-\|portal	portal protein	A0A2H4J180	uncultured_Caudovirales_phage	5.6e-124	50.1
WP_025336458.1\|4470882_4472637_-\|terminase	phage terminase large subunit	A0A2H4J484	uncultured_Caudovirales_phage	1.2e-237	68.3
WP_025336459.1\|4472655_4473096_-	hypothetical protein	A0A2H4J6Z8	uncultured_Caudovirales_phage	1.2e-27	48.9
WP_025336460.1\|4473492_4474044_+	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	6.6e-36	48.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP004078

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection