CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP007451	Draconibacterium orientale strain Draconibacterium orientale type strain FH5T chromosome, complete genome	9 crisprs	DEDDh,RT,csa3,cas3,PrimPol,cas9,cas1,cas2,WYL	2	3	1	0

1. NZ_CP007451

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP007451_1

• CRISPR_ID: NZ_CP007451_1
• CRISPR_location: 885975-886106
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP007451_1

Consensus_repeat	Method
AAATGCTTTAATGATTAAATGCTTCAATACAACCTCCACTCTC	CRISPRCasFinder

spacers of NZ_CP007451_1

>1.1|886018|46|NZ_CP007451|CRISPRCasFinder
TGCGAGACTCGGTAGATTCTCGGTGAAACTCTGTGGTAAAATGCGG

CRISPR arrays and Neighbor proteins around NZ_CP007451_1

CRISPR arrays

The CRISPR arrays of NZ_CP007451_1

>merge|NZ_CP007451|1|885975-886106|CRISPRCasFinder
AAATGCTTTAATGATTAAATGCTTCAATACAACCTCCACTCTCTGCGAGACTCGGTAGATTCTCGGTGAAACTCTGTGGTAAAATGCGGAAATGCTTTAATGATTAAATGCTTTAATACAACCTCCACTCTC

>NZ_CP007451|1|1|885975-886106|CRISPRCasFinder
AAATGCTTTAATGATTAAATGCTTCAATACAACCTCCACTCTC	TGCGAGACTCGGTAGATTCTCGGTGAAACTCTGTGGTAAAATGCGG
AAATGCTTTAATGATTAAATGCTTTAATACAACCTCCACTCTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007451.1|WP_038555716.1|882113_882596_-|cytidine-deaminase	unknown	unknown	gnl|CDD|273572
NZ_CP007451.1|WP_038555728.1|887395_888688_+|tyrosine--tRNA-ligase	unknown	unknown	gnl|CDD|235645
NZ_CP007451.1|WP_038555737.1|891303_891699_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038555734.1|889706_891194_+|O-antigen-ligase-family-protein	unknown	unknown	gnl|CDD|377422
NZ_CP007451.1|WP_038563773.1|883045_884608_+|carboxylesterase/lipase-family-protein	unknown	unknown	gnl|CDD|225181
NZ_CP007451.1|WP_038555692.1|877990_878401_+|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|376187
NZ_CP007451.1|WP_038555687.1|874611_876525_-|molecular-chaperone-DnaK	unknown	unknown	gnl|CDD|234715
NZ_CP007451.1|WP_038555731.1|888757_889705_+|hypothetical-protein	unknown	unknown	gnl|CDD|367147
NZ_CP007451.1|WP_168136387.1|876844_877954_+|DUF5009-domain-containing-protein	unknown	unknown	gnl|CDD|226749
NZ_CP007451.1|WP_139178085.1|878482_879829_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_051567584.1|892994_893357_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038555740.1|891765_891966_+|hypothetical-protein	unknown	unknown	gnl|CDD|379987
NZ_CP007451.1|WP_081804755.1|886576_886789_-|hypothetical-protein	unknown	unknown	gnl|CDD|236608
NZ_CP007451.1|WP_038555712.1|880988_881696_+|RluA-family-pseudouridine-synthase	unknown	unknown	gnl|CDD|223638
NZ_CP007451.1|WP_038555743.1|891968_892943_+|methionyl-tRNA-formyltransferase	unknown	unknown	gnl|CDD|234567
NZ_CP007451.1|WP_038555722.1|886218_886584_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038555709.1|879998_880814_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase	unknown	unknown	gnl|CDD|376814
NZ_CP007451.1|WP_038555684.1|873846_874398_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_CP007451.1|WP_051567583.1|886775_887159_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236608
NZ_CP007451.1|WP_051568143.1|885136_885961_+|glucosaminidase-domain-containing-protein	unknown	unknown	gnl|CDD|224619

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP007451.1|WP_038555716.1|882113_882596_-|cytidine-deaminase	gnl|CDD|273572	TIGR01354, Cytidine_deaminase, cytidine deaminase, homotetrameric. This small, homotetrameric zinc metalloprotein is found in humans and most bacteria. A related, homodimeric form with a much larger subunit is found in E. coli and in Arabidopsis. Both types may act on deoxycytidine as well as cytidine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides].	1.43584e-36
NZ_CP007451.1|WP_038555728.1|887395_888688_+|tyrosine--tRNA-ligase	gnl|CDD|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NZ_CP007451.1|WP_038555740.1|891765_891966_+|hypothetical-protein	gnl|CDD|379987	pfam17653, DUF5522, Family of unknown function (DUF5522). This is a family of unknown function. Family members are found in Bacteria and Eukaryotes. In algae, this family is found on the N-terminal of diphthamide synthase family pfam01902 and is predicted to be a membrane transporter belonging to The ATP-binding Cassette (ABC) family. In nematoda, it is found on the N-terminal side of ribosomal protein family L14 pfam00238. It is also found on the N-temrinal of Cob(I)alamin adenosyltransferase pfam01923 in other eukaryotes. Family members found in homo sapiens have been shown to be highly expressed in 15 high-grade neuroendocrine tumor cell lines and YAP1-positive small-cell lung cancer cell lines as well as being up-regulated in two human Multiple Myloma cell lines in response to selective nuclear export inhibitor KPT-276. The HMM profile of this family reveals 4 highly conserved cysteines.	1.72387e-17
NZ_CP007451.1|WP_038555734.1|889706_891194_+|O-antigen-ligase-family-protein	gnl|CDD|377422	pfam04932, Wzy_C, O-Antigen ligase. This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.	1.52618e-11
NZ_CP007451.1|WP_038563773.1|883045_884608_+|carboxylesterase/lipase-family-protein	gnl|CDD|225181	COG2272, PnbA, Carboxylesterase type B [Lipid metabolism].	7.98916e-116
NZ_CP007451.1|WP_038555692.1|877990_878401_+|nucleotidyltransferase-domain-containing-protein	gnl|CDD|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	5.87719e-21
NZ_CP007451.1|WP_038555687.1|874611_876525_-|molecular-chaperone-DnaK	gnl|CDD|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP007451.1|WP_038555731.1|888757_889705_+|hypothetical-protein	gnl|CDD|367147	pfam02706, Wzz, Chain length determinant protein. This family includes proteins involved in lipopolysaccharide (lps) biosynthesis. This family comprises the whole length of chain length determinant protein (or wzz protein) that confers a modal distribution of chain length on the O-antigen component of lps. This region is also found as part of bacterial tyrosine kinases.	1.34999e-05
NZ_CP007451.1|WP_081804755.1|886576_886789_-|hypothetical-protein	gnl|CDD|236608	PRK09652, PRK09652, RNA polymerase sigma factor RpoE; Provisional.	1.24977e-14
NZ_CP007451.1|WP_168136387.1|876844_877954_+|DUF5009-domain-containing-protein	gnl|CDD|226749	COG4299, COG4299, Uncharacterized protein conserved in bacteria [Function unknown].	5.14935e-41
NZ_CP007451.1|WP_038555712.1|880988_881696_+|RluA-family-pseudouridine-synthase	gnl|CDD|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	2.72046e-48
NZ_CP007451.1|WP_038555743.1|891968_892943_+|methionyl-tRNA-formyltransferase	gnl|CDD|234567	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed.	5.47883e-149
NZ_CP007451.1|WP_038555709.1|879998_880814_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase	gnl|CDD|376814	pfam02548, Pantoate_transf, Ketopantoate hydroxymethyltransferase. Ketopantoate hydroxymethyltransferase (EC:2.1.2.11) is the first enzyme in the pantothenate biosynthesis pathway.	8.93392e-160
NZ_CP007451.1|WP_038555684.1|873846_874398_-|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	9.70252e-08
NZ_CP007451.1|WP_051567583.1|886775_887159_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236608	PRK09652, PRK09652, RNA polymerase sigma factor RpoE; Provisional.	9.28796e-25
NZ_CP007451.1|WP_051568143.1|885136_885961_+|glucosaminidase-domain-containing-protein	gnl|CDD|224619	COG1705, FlgJ, Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion].	3.10333e-35

Protein sequences

>NZ_CP007451.1|WP_051568143.1|885136_885961_+|glucosaminidase-domain-containing-protein
MNRSGIPASITMAQGCLESGNGNSELSRKSNNHFGIKCKSSWKGKKVYYDDDRRNECFRSYRSVEDSYIDHSNFLMENPRYASLFLLDPTDYKGWAKGLKKAGYATAHDYDKRLIRIIEENKLHRLDKKMTFSPMGGQTAHNVLDTDKTGALTIKAFNSHKVSKINRVKAVVAQKGDTYEILAQELGLKDWELYKFNDQPPGHRPIPNEVVYIQYKKNKTSKNQLTHRAQEGETMHYISQLYGVKLNPLYRRNNMKKGEQPRLGQVIYLRKKKK
>NZ_CP007451.1|WP_038563773.1|883045_884608_+|carboxylesterase/lipase-family-protein
MKRVVKVIFFFTITAGFCFAACKPKTNNNQQPVIKTTYGEISGSINNSVYAFKGIPYAKAERFMPPQEPDAWDGVRECTEFGPVARQVVPWYPDSVQNEKELFSANVWTQGIGDGKKRPVMLWLHGGGFHTGASNDPMTYGEALAKKGDVVFVSINHRLNILGFLDLSACGEKYAKSANVGVLDIVKALEWIQKNIEQFGGNPADVTILGESGGGGKVGTIMCMPAAKGLFHKAIIQSGTLINTMTKEKSQALGLAVLENLGLTPDEVEKLETIPYKELVKAGNEAIAKTSGPRKPGSPTMFGFAPSADGDVLLQQPFSPGFATISKNIPLMIGSTLNELMPTAYSEKDLTLEAAKERLAKEYGDKTDEYISLFAEAYPDFTPQDLLSVDKTFRPFTIRTADARAQETDAPLYVYFLAWKSGVDNASKGSFHGLDIPLAFNTVDLRADWTGNTEEAWKLADKMSSAWINFVKTGNPNVEGVLPMWEQYTPENGATMYFDNECRIVNNHDRDLMHFIKPLD
>NZ_CP007451.1|WP_038555716.1|882113_882596_-|cytidine-deaminase
MRRKELTIKVCEYDTVGELPEMDQKLLLAAREASKNAYAPYSKFCVGAALLLENGEVITGSNQENADFTDGLCAERVALFYANSAYPNQAVKAIAVTAQNSHGFLELPAQPCGSCRQVLVETEFRYSQPIRIILDGRNYIQVLDGADNLLPFAFKPRDLE
>NZ_CP007451.1|WP_038555712.1|880988_881696_+|RluA-family-pseudouridine-synthase
MEVIYEDNHIIAINKACGDVVQGDKTGDETVLDKVKHYLKVKYNKPGNVYLGLPHRLDRPTSGILILAKTSKVLPRLNKLFQTKDGMRKVYWAVVDKRPPKYTDTLEHYLRKDQEKNRSYAYTEPRSDCKLASLTYRHVASIDNYHLLEVEIHTGRHHQIRVQLRQLNMHIKGDLKYGAPRSNKNKGIHLHARQVELIHPVRKEPLTIVADPPKDPVWDEFMKLFKAGKFSPVEV
>NZ_CP007451.1|WP_038555709.1|879998_880814_+|3-methyl-2-oxobutanoate-hydroxymethyltransferase
MSVHSEVRKVTTHRLSEMKLRGEKISMLTAYDYSMAQLVDEAGVDVILVGDSASNVMAGHETTLPITLNEMIFLGSSVVRAVNRALVVVDLPFGTYQGNSREALHSAIRIMKETAADAVKLEGGEEIIESVKRILSAGIPVMGHLGLMPQSIHKFGTYTVRAKQDAEAEKLISDAKLLEEAGCFALVLEKIPAALGEKVAKELKIPVIGIGAGGGVDGQVLVIHDMLGITQQFSPRFLRRYHNLAAEIKGAVGNYINDVKSQDFPSEKEQY
>NZ_CP007451.1|WP_139178085.1|878482_879829_-|hypothetical-protein
MRKLNSVFPKVYLPLILVFTVFMVHAQEPEINNDVVSFKKRELNWGLILGVSKESEELLSDESRFDEDRTLLNGKFRIENTYWNLLDYKQERLNMRFEVGPYGGYGDWIDSSKVEYITADQDFYGVRTSANIDYSYRYYYDAKSYTVIDVSGWGRYEVFKQNLDGTSTDSLGVTTPVDESDTKDRLRYGLNAKVGWGSGRLSPMNHLMTAHYLLEKYYPGRLFSDYEIAQFAQVIANIKHNRDFKGGHVPEKEMEEVVDFIRSTFVLASPESMGAEWQFSEFDPRYQGNRFEIGPHFKYYNQEPDFLFGGYMQYDNAKYVNVKWNRNLSAALVYNRYTKTDMEYIDEHLVNSNVSRDWATADINLGWSYFPNLKTQFDFGIRYVPGIQLNNFDEVGSLSNNFIPYVAYFTQLNSKSRVKLNAAWRIADGEQFVVPGPEFSLSIYRSKY
>NZ_CP007451.1|WP_038555692.1|877990_878401_+|nucleotidyltransferase-domain-containing-protein
MSTLPENIIIDFLQKHIAGVYAVYLYGSFANGVTTAESDVDLAFLSEAHITNVAKWKIQEKLAAALNKDVDLVNLKDASVVLRKEIVEKGQLLYSSDRYKTESFEMTTLSMYLDLNETRKDILNDYKEKYGRDPSK
>NZ_CP007451.1|WP_168136387.1|876844_877954_+|DUF5009-domain-containing-protein
MTTKSLRTEPQKRLQSLDVLRGFDMFWITGGGALATAISQITGTDWLGEQMHHADWAGFHFEDLIFPLFMFIAGVAIPFSIKAKIEKNVPKKRLALKALKRMVILILLGILYNGVFQNGFANGRIASVLGQIGIGYFFASLIVIYFHSFKSRIYWLAGILAGFGIIQLLIPVPGVGAGVLTPEGCINGYIDQLFLPGRLYGGTFDPEGIMCSLSATGITLMGTIAGNILRNRKTTDWQKIGYMTATGVGLIVLALVFSTFYPIIKKCWTSTFNMLAGGISFLLMALFFLIIDHWKIRSWAFYFRVIGMNSIFVYLFVRIIDMQYITEFFFGWITKPMGNAGSFLMLILGLALIWGLLYYMYKKKIFLRV
>NZ_CP007451.1|WP_038555687.1|874611_876525_-|molecular-chaperone-DnaK
MGKIIGIDLGTTNSCVSVMEGNEPVVIPNSEGKRTTPSIVAFVENGERKVGDPAKRQAITNPTKTIFSIKRFMGETFDQVSKEVARVPYKVVKGDNNTPRVEIDDRKYSPQEISAMTLQKMKKTAEDYLGQEVTEAVVTVPAYFSDSQRQATKEAGEIAGLKVRRIINEPTAASLAYGLDKMDRDMKIAVFDLGGGTFDISILELGDGVFEVKSTDGDTHLGGDDFDQVIIDWLADEFNSEEGIDLRKDPMALQRLKEAAEKAKIELSSSSQTEINLPYIMPVNGIPKHLVKTLSRAKFEQLADTLINATIEPCRKALKNAGMTAGDIDEVILVGGSTRIPAIQNKVKEFFGKEASKGVNPDEVVAIGAAIQGGVLTGEVKDVLLLDVTPLSLGIETMGGVMTKLIESNTTIPTKKSETFTTAADNQPSVEIHVLQGERPIASGNKTIGRFHLDGIPPAPRGVPQVEVTFDIDANGILHVHAKDKATGKSQSIRIEASSGLSDEEINRMKSEAEANAEADKKAKETADKINQADSLIFQTEKQLKEYGDKLPADKKGPIEDALKKLKEAHASKDLAAIDAAMNELNTVFQAASQEMYNASQAQGGAQPGPDAGQQGGAQDQPKDDGEVTDVDFEEVK
>NZ_CP007451.1|WP_038555684.1|873846_874398_-|helix-turn-helix-domain-containing-protein
MVISKIQKNCEVCKEPFIPKTVNSVYCSKTCSDTAYRKRKAEKKKEEQRKALAERIPKDRMYLSVPEAIILFGVAKSTLYRLVRQGRIPAINLGTRLVRIERKAVEQMFPIKKERSTTKKNSKVKLYRLEPEDCYTIGEITQKFGISASSVYKHIRKFSIPIRQIGKYVYAPKTEIDSIYESK
>NZ_CP007451.1|WP_038555722.1|886218_886584_-|hypothetical-protein
MYNENRNFDTDKLLKEAFTSEPEFKLSENFTDDLVKKVEQHFAWQQYLREFAIYLAVILGIMLVTAVLAFVWFDVTVSGWMAFFTQNASLVVGINLLGVFVLFADRVLLRYFMYRAASNAA
>NZ_CP007451.1|WP_081804755.1|886576_886789_-|hypothetical-protein
MQLIESLPVNYRTVITLFHLEEFSYKEIEAITGMPEGTIKSYLSRARIVLKGKIEKVARLEQTNIFVDYV
>NZ_CP007451.1|WP_051567583.1|886775_887159_-|sigma-70-family-RNA-polymerase-sigma-factor
MNDAQLVQQVLNGNNHAFRFLAGKYQRLVMHVVGRIIQQEDEREDICQEVFIKVFKKLKRFRGDSKLSTWIASIACNTAITHYRKQKRRGELSYNEEPNLLLNEQDSGLNQKIIEKEEAKKISTATY
>NZ_CP007451.1|WP_038555728.1|887395_888688_+|tyrosine--tRNA-ligase
MSFVQELKWRGMLHDIMPGTEEQLEKELTAAYVGIDPTADSLHIGHLVSVMMLKHLQIAGHQPIALVGGATGMIGDPSGKSQERNLLDEPTLRHNQECIKAQLAKFLDFESKEENVALLVNNYDWMKEFSFLDFIRDVGKRITVNYMMAKDSVKKRLGEESKSGMSFTEFTYQLVQGYDFYHLYKNNNCRLQMGGSDQWGNITTGTELIRRMDGGEAFALTCPLITKADGTKFGKTESGNVWLDPERTSPYAFFQFWLNTSDEDAERYIKIFTLLSKEEIDTLVAEHKEAPHARALQKKLAEEVTTMVHSREEYDMAVEASQILFGKGTAEQLRKLNESTFLAVFEGVPQFNISKNELAAGINVIDLLAEKTEVFPSKGELRRTIKGNGLSINKEKISDPDLVVNNDFLIGGKYILAQKGKKNYFLIIAE
>NZ_CP007451.1|WP_038555731.1|888757_889705_+|hypothetical-protein
MDNFFDNQRILQLIWKRKFHFVLVGVIAVVLSAIFSGPTFITPKFKSTARLYPTNIWTMSDESETEQMLEILNSNDIKFRMFDSFDLAKVYKVNKDDPQYITYMLAEYNTNVSTGKTEFETAEIKVLDEDPQRASAMCDSIISFFNQKVQELHKAKEKEMLDITGRQLDRKYNELEVYEHKLDSLREKYGIISYGQVDEVTRGYMNALASGRGSAGDTKKIEQLYDNFSKEGSRAFKLENKYNKTIEVIDSLSIVYDSYLTEYEKEITYSHVVEHPFPADKKAYPVRWLIVAFTTLSALFFALLVFLVLDYEKKD
>NZ_CP007451.1|WP_038555734.1|889706_891194_+|O-antigen-ligase-family-protein
MPQKTIIRIALFYLISIGFIALNLWVVVEKHMLYANVLPLVFVVILLAVFSFDKLVFLIAFLAPLSIPLREYLPGIGFDMYIPTEPLLFGLLLLFILKVIQERQFDRKILLHPVSLAVYLNLFWILITSVTSTMPLVSFKFLLMRIWFVVGLYLLTAKIFKDGKNMEKYVWLYVIPLMLVIFYSTYRHLGYGLWDKQAAHFVVSPFYRDHTSYGAATAIYIPFLVMFILSKSYSKNIRLLAAGALAAVTLGFLLSYSRAAWLSIIVAFGVWSIIKLRIRFKPLFITLITIIGLFLAFQSQILMKLEQNSEESSANMMTHISSMSNISSDASNLERINRWSCAVRMFADKPVVGYGPGTYMFKYARYQLSKDRTIISTNSADGGNAHSEYLGPMAESGVLGLATYLLIIILVIYTAVNTYTRLTDYRLRSIVLAALVGLVTYYIHGFLNNFLDTDKISVPFWGFTAMIVAIDILSRKQEKDTEPKQLTESDISDQS
>NZ_CP007451.1|WP_038555737.1|891303_891699_-|hypothetical-protein
MGVEKDYLMRQLMMLFEVIQKILRHRRKGEDEEAEKQIQFFYEYLKIDEDVEKLSVEALIDLLEKDKNLVNEQLEMVAFVLKEQGELADSDDKRLDFFRKSYFILQKVERESISFSIDRQMKIAELSAYLN
>NZ_CP007451.1|WP_038555740.1|891765_891966_+|hypothetical-protein
MGYFDDLFPDRYEDELQEGKDFYMENGYRVMTESYLINRGYCCANGCRHCPYWPKAQKGNTNLRKK
>NZ_CP007451.1|WP_038555743.1|891968_892943_+|methionyl-tRNA-formyltransferase
MQGKDLRIVFMGTPDFAVASLQALVEGGYNVVGVITAPDKPAGRGKKLHQSAVKIYASEKGLNVLQPEKLKNPEFLDELRALETDLQVVVAFRMLPEVVWDMPRLGTFNLHGSLLPQYRGAAPLNWAVINGETKTGVTTFLLAHEIDTGKILFRKEIDIWENDTVGTIHDALMEIGAKLVVQTVDALATGNYKAIPQEELVAEGEEIKHAPKIFKENCKIDWSADADAVRNLIRGLSPYPAAWSTLKHKETGKETATKIFMAMRVEDNKNTPAGTLESDGKNFIKVACTNGWLQITDLQIAGKKRMKVQDFLRGFQQIGDYTFL
>NZ_CP007451.1|WP_051567584.1|892994_893357_-|hypothetical-protein
MMPEVIVTAVVFFATYHIIRLISNHLLKRKLIKAEQYERVGILEEPKVENDESNRYPSLKWGLVALMTGLGFIIIEVMGLFNREMVRGRDAVLPLGILMVCISLGFLIYFFIMNGKAVKK

Crispr_ID: NZ_CP007451_2

• CRISPR_ID: NZ_CP007451_2
• CRISPR_location: 1033006-1033192
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_CP007451_2

Consensus_repeat	Method
CAATCCTGACGNTTNAGATTCAT	CRT

spacers of NZ_CP007451_2

>2.1|1033029|18|NZ_CP007451|CRT
ATTTTGCCCGCAAAATGG
>2.2|1033070|18|NZ_CP007451|CRT
ATTCTGTGCATAAAACGT
>2.3|1033111|18|NZ_CP007451|CRT
GTTTTGTGGGGAAAACAA
>2.4|1033152|18|NZ_CP007451|CRT
ATTTTGTACGTAAAATGG

CRISPR arrays and Neighbor proteins around NZ_CP007451_2

CRISPR arrays

The CRISPR arrays of NZ_CP007451_2

>merge|NZ_CP007451|2|1033006-1033192|CRT
CAATCCTGACGATTCAGATTCATATTTTGCCCGCAAAATGGCAATCCTGACGGTTCAGATTCATATTCTGTGCATAAAACGTCAATCCTGATCATTTTTTTTCACGTTTTGTGGGGAAAACAACAATCCTGACGATTCAGATTTATATTTTGTACGTAAAATGGCAATCCTAACGGTTTAGATTCAT

>NZ_CP007451|2|1|1033006-1033192|CRT
CAATCCTGACGATTCAGATTCAT	ATTTTGCCCGCAAAATGG
CAATCCTGACGGTTCAGATTCAT	ATTCTGTGCATAAAACGT
CAATCCTGATCATTTTTTTTCAC	GTTTTGTGGGGAAAACAA
CAATCCTGACGATTCAGATTTAT	ATTTTGTACGTAAAATGG
CAATCCTAACGGTTTAGATTCAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007451.1|WP_038563831.1|1028914_1029826_-|DMT-family-transporter	unknown	unknown	gnl|CDD|307170
NZ_CP007451.1|WP_038555973.1|1033676_1035365_-|asparagine-synthase-B	unknown	unknown	gnl|CDD|236513
NZ_CP007451.1|WP_038555958.1|1025998_1026787_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_081804759.1|1021238_1024394_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|274948
NZ_CP007451.1|WP_038555997.1|1043621_1047890_-|DNA-directed-RNA-polymerase-subunit-beta'	unknown	unknown	gnl|CDD|234794
NZ_CP007451.1|WP_038556003.1|1051846_1052224_-|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl|CDD|234671
NZ_CP007451.1|WP_051567598.1|1030241_1031339_-|redoxin-domain-containing-protein	unknown	unknown	gnl|CDD|239264
NZ_CP007451.1|WP_038556000.1|1047932_1051742_-|DNA-directed-RNA-polymerase-subunit-beta	unknown	unknown	gnl|CDD|234749
NZ_CP007451.1|WP_038555991.1|1041621_1042497_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl|CDD|238847
NZ_CP007451.1|WP_038555967.1|1031461_1032343_+|patatin-like-phospholipase-family-protein	unknown	unknown	gnl|CDD|132866
NZ_CP007451.1|WP_038555994.1|1043284_1043611_-|DUF3467-domain-containing-protein	unknown	unknown	gnl|CDD|371814
NZ_CP007451.1|WP_038555985.1|1038836_1040546_-|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|173842
NZ_CP007451.1|WP_038555964.1|1027531_1028833_+|hypothetical-protein	unknown	unknown	gnl|CDD|283275
NZ_CP007451.1|WP_038555952.1|1018812_1019892_-|IS110-family-transposase	unknown	unknown	gnl|CDD|376773
NZ_CP007451.1|WP_038555961.1|1026859_1027441_-|peptidylprolyl-isomerase	unknown	unknown	gnl|CDD|365914
NZ_CP007451.1|WP_038555988.1|1040568_1041588_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl|CDD|224936
NZ_CP007451.1|WP_038555976.1|1035949_1036696_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187662
NZ_CP007451.1|WP_139178103.1|1036866_1038285_-|hypothetical-protein	unknown	unknown	gnl|CDD|238885
NZ_CP007451.1|WP_038555970.1|1032335_1032902_+|hypothetical-protein	unknown	unknown	gnl|CDD|179112
NZ_CP007451.1|WP_038555955.1|1024406_1025987_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|185760

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP007451.1|WP_038563831.1|1028914_1029826_-|DMT-family-transporter	gnl|CDD|307170	pfam00892, EamA, EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.	1.87233e-12
NZ_CP007451.1|WP_038555973.1|1033676_1035365_-|asparagine-synthase-B	gnl|CDD|236513	PRK09431, asnB, asparagine synthetase B; Provisional.	0
NZ_CP007451.1|WP_081804759.1|1021238_1024394_+|TonB-dependent-receptor	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP007451.1|WP_038555997.1|1043621_1047890_-|DNA-directed-RNA-polymerase-subunit-beta'	gnl|CDD|234794	PRK00566, PRK00566, DNA-directed RNA polymerase subunit beta'; Provisional.	0
NZ_CP007451.1|WP_038556003.1|1051846_1052224_-|50S-ribosomal-protein-L7/L12	gnl|CDD|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	1.74291e-36
NZ_CP007451.1|WP_051567598.1|1030241_1031339_-|redoxin-domain-containing-protein	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.4256e-31
NZ_CP007451.1|WP_038556000.1|1047932_1051742_-|DNA-directed-RNA-polymerase-subunit-beta	gnl|CDD|234749	PRK00405, rpoB, DNA-directed RNA polymerase subunit beta; Reviewed.	0
NZ_CP007451.1|WP_038555991.1|1041621_1042497_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl|CDD|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	7.60421e-71
NZ_CP007451.1|WP_038555967.1|1031461_1032343_+|patatin-like-phospholipase-family-protein	gnl|CDD|132866	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6. Bacterial patatin-like phospholipase domain containing protein 6. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This group includes YCHK and rssA from Escherichia coli as well as Ylbk from Bacillus amyloliquefaciens.	6.46207e-63
NZ_CP007451.1|WP_038555994.1|1043284_1043611_-|DUF3467-domain-containing-protein	gnl|CDD|371814	pfam11950, DUF3467, Protein of unknown function (DUF3467). This family of proteins are functionally uncharacterized. This protein is found in bacteria, archaea and viruses. Proteins in this family are typically between 101 to 118 amino acids in length.	3.81054e-35
NZ_CP007451.1|WP_038555985.1|1038836_1040546_-|acyl-CoA-dehydrogenase-family-protein	gnl|CDD|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	8.39861e-162
NZ_CP007451.1|WP_038555964.1|1027531_1028833_+|hypothetical-protein	gnl|CDD|283275	pfam05576, Peptidase_S37, PS-10 peptidase S37. These serine proteases have been found in Streptomyces species.	2.42174e-55
NZ_CP007451.1|WP_038555952.1|1018812_1019892_-|IS110-family-transposase	gnl|CDD|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.2869e-24
NZ_CP007451.1|WP_038555961.1|1026859_1027441_-|peptidylprolyl-isomerase	gnl|CDD|365914	pfam00160, Pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyze peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.	1.73297e-37
NZ_CP007451.1|WP_038555988.1|1040568_1041588_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl|CDD|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	6.84856e-104
NZ_CP007451.1|WP_038555976.1|1035949_1036696_+|SDR-family-oxidoreductase	gnl|CDD|187662	cd09761, A3DFK9-like_SDR_c, Clostridium thermocellum A3DFK9-like, a putative carbohydrate or polyalcohol metabolizing SDR, classical (c) SDRs. This subgroup includes a putative carbohydrate or polyalcohol metabolizing SDR (A3DFK9) from Clostridium thermocellum. Its members have a TGXXXGXG classical-SDR glycine-rich NAD-binding motif, and some have a canonical SDR active site tetrad (A3DFK9 lacks the upstream Asn). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.70263e-99
NZ_CP007451.1|WP_139178103.1|1036866_1038285_-|hypothetical-protein	gnl|CDD|238885	cd01902, Ntn_CGH, Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that inhabit the gut. CGH has an N-terminal nucleophilic cysteine, as do other members of the Ntn hydrolase family to which CGH belongs.	8.96132e-17
NZ_CP007451.1|WP_038555970.1|1032335_1032902_+|hypothetical-protein	gnl|CDD|179112	PRK00758, PRK00758, GMP synthase subunit A; Validated.	2.06088e-37
NZ_CP007451.1|WP_038555955.1|1024406_1025987_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	2.0075e-33

Protein sequences

>NZ_CP007451.1|WP_038555970.1|1032335_1032902_+|hypothetical-protein
MAELLVVNNAEPGIREFAEPILQIISDAGSTPAFIEYAECPATNLSAFDGIILSGSPQGDDIVEHHAPYFQWIKYLEKPVLGICAGHHITGYLYGAKLLRSQEPESGDFEVKIVKTDPLFNELPQKFTVRQMHNDSITLPNDFELLLTSSSCKNQLMKHKNKPLYTCQFHPEFYNHRLIRNFIELCKK
>NZ_CP007451.1|WP_038555967.1|1031461_1032343_+|patatin-like-phospholipase-family-protein
MSKNIALVLSGGAARGMAHIGVIEELEARGYNITSIAGTSMGALVGGIYALGKLPEFKEWLISLDRHDMFRMVDFSFGGNGLIKGDKVLAKIQEFVPDALIEDLPIPFSATAVDLKHREEVVFTTGSLFSAIRASIAIPSVFTPITSENAVLVDGGVMNNLPVSNVKRTEGDRLIAVHVNAAIPVPHYFVEKEDSEAKESTYKKWLNEFYDFLHINHPKEKEERFGLLSLIDQALATAMLTQVNHSIEKGKPDVVIRVSRDACGTYDFYKAKELIEMGRYSAIHELDKAKFNG
>NZ_CP007451.1|WP_051567598.1|1030241_1031339_-|redoxin-domain-containing-protein
MRKLLVAIIALALFACSQQQDGYKITVNIEGADGNVMLEQRGASQWIGIDTAVVVDGVAVLEGEVEFPGLYYLSVNGQREKAVLFVENTNITVTGKADSIAGVQVSGSTTHDEFKTINDQIQKISEEYMAIYQEARTASAAGDTAKANELMKQVEDLYASVGEIQEDFVKENPASYVTPLLLSQIQYEKEVDELEALVSNLDAKLDSVPAIIDLKAKIEQLKTVAVGKTAPDFTQNDADGNPVKFSDIYSKNELTLLDFWASWCGPCRQENPNVVATYNKYKDQGFSVFGVSLDRDKDAWLKAIEDDGLTWAHVSDLAYWNNAAAKIYAVNSIPSSLLVDKNGKIIAKNKRGEELGKTVAEFLSK
>NZ_CP007451.1|WP_038563831.1|1028914_1029826_-|DMT-family-transporter
MQNHFGEIAGVLTAVFWTVTALAFESAGKKVGSLAVNLIRLVIAFFLVGAYSWVTRGFFFPSDASMYAWKWLAFSGLVGFVIGDLLLFQSFVLIGARIAMLLMALAPPFAALIGWLLLGEVLSPQSWLGMTVTMTGIIIVILKREKSEENGVKIRKFKSSYPIQGILLALGGAMGQAAGLVISKKGMGDYDAFSATQIRILAGTVGFSILFIFIKRWPRVWAALKNGPAMKRITLGAFFGPFLGVSFSLLAVQHTQAGIAATLMAIVPVLIIGPSILLFKEKVNWKEILGAVITVVGVAMFFL
>NZ_CP007451.1|WP_038555964.1|1027531_1028833_+|hypothetical-protein
MKKLQLLLVLLLLSAVSFSQTTLKVFLERQPEVKSVEQMDCTDFFAAKYKIMVEQPVDHSDPAKGTFLQRVLIADKGIDRPVVFITEGYNGGYSENPNYINELCPILEANQICMDHRYFGESMPEPLNYDYLTVRNAAADHHHIIQLMKKYYSGKWISTGISKGGQTTVYHRWLYPNDVDISVPYVAPLNFGVEDGRHEPFIANTTGTPEGRAKVQAFQLQILKNRETYLPLLEQYCKNQHLNPLLNNDELLDYVVLEFSYGFWQYDNSLDDIPALDAPAKDLFAELVKVSSPMYLASEGVDIFKSFYVQAAHELGYYGYDIEPFKEYLSITSAEGWLNRIYLPELAIKYNKKTAKEVKKFIKKTDAKMLFIYGEWDPWSASAFDVPGKPNFLKIVKPEGSHSTRIGNLPKEQKQQVKETLEDWLDMEVNIEI
>NZ_CP007451.1|WP_038555961.1|1026859_1027441_-|peptidylprolyl-isomerase
MRKAIIFIIPVLLLAFQAATQELPRVEMQTELGIILVEIDTINAPLTATNFLQHVEAGTYKNACFYRVVRLDNQPNNDVKIQVIQGGMYTEPRFETIQPIAHETTEATGLKHLNGTMSMARMEPGTASTEFFICVGDQPELDFGGKRNPDGQGFAAFGQVISGMDVVRKIQQQKDEQQTLVDKVKIKEIKTAF
>NZ_CP007451.1|WP_038555958.1|1025998_1026787_+|hypothetical-protein
MKKIQLALLVFVLSLAACDQDNIGELYETDAYVAFSTEIVPANILTAENNYSVNVQIARSNLNAPTTAQVSLEMNENIEGVFDLESTSVSFAEGEGTAYAKIVPLVDISQIDVSKVYEFNLTLTGDNVSEFYSQTTYRASFLLTFEPVGTGTFSSEFRENEWTVQVEKALEADVYKIIDCYAEGYDIMFSVDAENNVFYATQLTGYIDPDYGMVTLEMPDSEEPDSYYMGEPYRNGNTIYLLGRFTVDAGSYGHWYEVLTLP
>NZ_CP007451.1|WP_038555955.1|1024406_1025987_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKIDKILILLFLVFAGFACQDELDTNPTDSTSGDVLFSDVQKANVALNGIYRAMYVAEEWSANWADEEFGVTAFLLTYDLMGEDMVQNEGGSGWFWFDYMYNVKSDYTHKSGRPYSVWFFYYTLISNANSIIASQEVLTGAPSEINSLIGQAYALRAYAYFSLIRFYQQTYVGNENAPGVPIYTEPTTNISEGSPRGTVADVYTQIDADLQQALALLNPEVAAPRTHSSHIDYYVANGLKAQVALEKQDWASAESAATMAMSGGTTMLSHENLANGFAFNNANAGAVLWGLQIIAEQISDTESLFGHMDASTQSYAENARKCVSSWLYNQMADTDVRKQMWWNGPLEVNEPLGTQLSYNQFKFRFSDPTNALGDYILMRHEEMMLIKAEALCMQNRFGEARTILAELMEERDPNYDISGLTDANTLTVNDANGPTTPLNGSSTLLDEIILQRRIELWGEVGRIFDIKRLKTGFSRDFEGSNHTQKLLSRNTLDPEYPDFVMSIPQSEFDGNKNMDEVSDQNPWADN
>NZ_CP007451.1|WP_081804759.1|1021238_1024394_+|TonB-dependent-receptor
MKKLLLLVVALFCGVGILFAQTKQIRGTVTSSDDGLPIPGVSVAVKGTTSGTTTDLDGNFTLTVPADEILIFSFVGMKREEVPITDATVYNVTLEPDVIGVDEVMVVAYGTAKKESFTGSAGVVDNEMLQKRPVADISKALEGQVAGVQTTSGTGQPGEGAEIVIRGFGSINSSNNPLYVVDGVPFDGNLNSINPGDIESMTILKDASAGALYGSRGANGVVVITTKKGQSKELSVELKATYGFSSRAIKPYETLGTADFIEASFQGYKNALIYTDGVHPDMAGPMAVDALKGSSGIFGANEMYNPYNMPVSELIDPQTGQVNPSAKLLYESDWLDEVTNDNATRQEYQLFINGGSDNSQVYASVAYLKDEGLLKTTDFERISGRIGAELTPKNWFKYGGNVNFSKTETNYLGYDGTTSNSNVWYSAQFMAPIYPVYVQDENGNPILSETGKKQFDYGLTRPSGANPNWNPVATLYEDAYETTADNLSGRFHLNLLGLGLGSSFDGLSFTTNVGFDYINTNQTVYWNPDFGNAANIGGYLDKTIVRSLSYTINQLLRYEKDFGKHSINVLAGHEFYKLTINEMEGSKSGFPYSGIKELAPGSTTSGLTSFEDNYSIESFLSNVTYDFADRYYLSASFRTDGSSRFHKDFRWGNFWSVGGSWRISEESFMEEMTFIDNLKLKASYGKQGNDNIGTYYGWQSLYNLDWANANLNGALLSSLENTSIKWEENNNFNVGVGAVLFDRFDISFEYYRRRTVDMLMEKPMATSLGFDSYWANVGEMLNTGFEFNANLNLISNPNFVWNANFNLTSLTNEIVELDGETDQIVNGNIIQRKGAEINSYYLAQSAGVDAATGAQLYWVYDLDADGKPGDSYLSDDYQKASQNKRISGSRIPDFYGGFGSNFKIYKNFDMSFMTTFSVGGEVYESVYSNLMNPIYIGTNYAANVERAWRKPGDVTDIPRIQNGTGFSRPFTDSQLIDASYFSIKNITVGYTLPKTILQNVGIESVRAYVAVDNLAIFSHLDGMNPQFDFSGTTDFSYTPVRTSLFGIEVKF
>NZ_CP007451.1|WP_038555952.1|1018812_1019892_-|IS110-family-transposase
MQGKVKTISFQGQNIYIGIDAHLKNWTVTAMTENSLTKTISQNPDAGTLYTYLQRTFPGGNYLSAYEAGFCGFSAHRNLEKYGIKSIVVNPADIPTTDKERKQKEDRRDSRKIARSLKNGELTGIHVPDKETEELRSLVRYRKTLVKEISRHKSRIKSHLHCFGIAIPGPLAQASTYWSGKFTQWLEEVQQSTPYGGMVLQSTLATVKHLRAELLKINRKLRELEKEVMYGFKIKLLRSIPGIGLIVAVTLLSELETILRFKNLDKLCSFVGLVPRTNTSGENDKTGKITSRSNKPLRGIIIEAAWIASRNDPALAQCYLELCKRMKPNKAIIKIAKKLLNRIRYVMKNEKEYVHSVVQ
>NZ_CP007451.1|WP_038555973.1|1033676_1035365_-|asparagine-synthase-B
MCGIVGAFDLKVKAEDLRPQVLMMSKKVRHRGPDWSGIYCGEKAIIAHERLSIVDPESGGQPLYSKDGKLILGVNGEIYNHREIRKRYEGKYDFLTKSDCEVILALYNDKKEKFMDEMNGIFAFALYDEVNDAYLIGRDHIGIIPLYQGWDKWGNYYVASELKSLEGFCTKIEEFPPGHYLYSKDGELKKWYVRDWEEFDNVKDNPASVDELSQALEDAVHRQLMSDVPYGVLLSGGLDSSITSALAKKFSAKRIEDGDEKDAWWPQLHSFVIGLEGSPDLAAARKVADHIGTVHHEINYTIQEGLDAIRDVIYHIETYDVTTVRASTPMYMLARVIKSMGIKMVLTGEGADEIFGGYLYFHKAPNAEEFHKESVRKVSRLNKYDCLRANKSLAAWGVEGRVPFLDKEFVDAAMRFNPEAKMAKDGKMEKHCLREGFASYLPEEVAWRQKEQFSDGVGYGWIDTLKQIAEDKVSDEMMENAKYRFPVNPPMNKEEYVYREIYSEHFPSDAAAACVPSEASIACSTAAALEWDASFQGNADPSGRAVNTVHAQGATFKDIKKK
>NZ_CP007451.1|WP_038555976.1|1035949_1036696_+|SDR-family-oxidoreductase
MKKHVIVTGGAQGIGKHLVVDLLNNNYAVSVFEIDEEAIAKFREEFTNETVQVYQVDVSDEKSVEAAVKESEKQHGNIYALVNNAAISINKPLEELSFGEWNKVIGTNLSGAFLCSKYASAFMKPHGGRIINMASTRALQSEPDTEAYSASKGGILALTHALAASLGPQIKVNAISPGWIDVSAAKKSSIAHQEKLTKEDHAQHPAGRVGKAEDIAAMVLFLLKKENDFITGQNFVVDGGMTKKMIYV
>NZ_CP007451.1|WP_139178103.1|1036866_1038285_-|hypothetical-protein
MRIQQAIIALFVTSLFLLLPQHKGVLASSTFKLQKGNTLIYGHNINEGDIGVPGLVFINKRGMFKTGRTWSEIITRGRVNPSSHTWISRYGSVTFNNFGKDFPDGGVNEAGLFIWEMNEEADYPKNDSLPKLNQMNWMQYILDNYSTTEEAIRSATEFEIDGWSCHFFVGDAGGNTAAIAFINGQVVVHTGDEMPVPALFNAPYDRELELSKYFRGFGGEYQPNETDPNVPRFVRTAVMIDNYQKEDDPIDYGFYMLKTLRVFDDPEWSILFDARNRTVHFRTHINPERKTLMMDEIDFSNNEPAQVLNMATAFSGNIRSVFEPYTKSIMQYFISNELLPVLSRDFISHGDLSGKAFTERIVNHTDSYADSTNHFFKGTWESARTVDDDEPLYSINFDVEGSAVAAVIFLDSADEPYNVDNLTMSGNQFCFTFQTKSGKILEVKGTIRDDVMFVNLLGIEKSFGDYTLKRTH
>NZ_CP007451.1|WP_038555985.1|1038836_1040546_-|acyl-CoA-dehydrogenase-family-protein
MANYYTDNSELKFHLNHPLMKEIVRLKEREYTFKDEFDFAPLDYEDAIDSYDRVLEVVGEICGNIVSENAESIDAEGPEVIDGHVKYARGTEENIKALNQAGLMGMSLPYKYEGLNFPIVPYIMAADIVSRADAGFVNIWGLQDCAETINEFASEEQKAKYLPRVCNGDTMAMDLTEPDAGSDLQAVQLKATWNEEKQVWLLNGVKRFITNGDGDISLVLARSEAGTTDGRGLSMYIYDKQSGGVTVRRIEHKMGIIGSPTCELVFKDAPAELVGSRKMGLIKYVMALMNGARLGIAAQSVGVCEAAYREAMAYAKERMQFGKAIIKFPAVFEMLSLMKAKLDASRTLLYETARFVDMYKTYMHISEERKLEKEERDEMKKYQRLADIFTPLVKGMSSEYSNQLAYDAVQIHGGSGFMKDYPVERIYRDARITSIYEGTTQLQVVAAIRGVTTGGYLNQIRAYEAEKVSPTLEYLKRTLIILTADYEEAVKKVTAAGDNEFVDFHARRLVEMAGHIIMSYLLLLDTNREASFLKSTKNYIAFAKAQVKAHAEFIRASELSDVGDYKFEM
>NZ_CP007451.1|WP_038555988.1|1040568_1041588_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MSNVFVYCEIEDGQVADVSQELLTKGRTLANELKCKLEAIAIGSKLDKVGDQIIPYGVDTLYIADDERLFPYQTLPHTSIVVNLFKEQKPQIALMGASSIGRDLGPRVSSALHSGLTADCTSLVIGDHYDKKQDKNYENLLYQIRPAFGGNIIATIINPDCRPQMATVREGVMKKEILDPKYKGKVVKLDVAKYVSDEDFVVEIIERHMEKSKVNVKGAPIVVAGGYGVGSKENFQLLYDLAEVLGGEVGASRAAVDSGLAGHERQIGQTGITVRPKLYIACGISGQIQHRAGMEDSAQIIAINTDPEAPINAIADYVITGDVAEVIPKMIKYYKKNTK
>NZ_CP007451.1|WP_038555991.1|1041621_1042497_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MKAYNIIVLAKQVPDTRNVGKDAMKADGTINRAVLPAIFNPEDLNALEQALRIKDQFPESKINILTMGPGRAADIIREGLYRGVDGGILLTDRAFAGSDTLATSYAIGQALKKMGKIDMIIAGRQAIDGDTAQVGPQVAEKLGMLQITYVEEVLEVKDKTVTVKRRLENGVETAKCPMPLVMTVNGSAPDCRARNAKRIMKFKKARTVTELQKENEDYTALYNEHPDLMIQEWTVNDIETDASQLGLTGSPTKVKTVENVVLQAKDSKVISAADDEIEAMMVELIKSHTIG
>NZ_CP007451.1|WP_038555994.1|1043284_1043611_-|DUF3467-domain-containing-protein
MEDKKHKSQQINIELNEEVAQGTYSNLAVITHSTSEFVVDFVRIMPGIPKANVKSRIILTPEHAKRLLMALQDNIAKFEAQHGPIKNVNSGNDPNLPPMNFGGPTAQA
>NZ_CP007451.1|WP_038555997.1|1043621_1047890_-|DNA-directed-RNA-polymerase-subunit-beta'
MAFKKDNKAKTSFSKVSVSLSSPEEILERSYGEVLKPETINYRTYKPERDGLFCERIFGPVKDYECHCGKYKRIRYKGIVCDRCGVEVTEKKVRRERMGHISLVVPVAHIWYFKSLPNKIGYLLGLPTKKLDTIIYYERYVVIQAGVKHQDGVKELDFLTEEEYLDILDTLPKENQFLDDDDPNKFIAKMGAEALFDILSRLELDDLSFTLRHKANTETSQQRKNEALKRLQVVEAFRASKNLNRPEWMIVRVVPVIPPDLRPLVPLDGGRFATSDLNDLYRRVIIRNNRLKRLIEIKAPEVILRNEKRMLQEAVDSLFDNSRKSNAVKTENNRALKSLSDSLKGKQGRFRQNLLGKRVDYSARSVIVVGPKLRIHECGIPKDMAAELYKPFVIRKLIERGIVKTVKSAKKIVDRKDPVVWEILENVLKGHPVMLNRAPTLHRLSIQAFQPVLIEGKAIQLHPLVCTGFNADFDGDQMAVHLPLGNAAILEAQLLMLASHNLLNPANGAPIQVPSQDMVLGLYYMTKPRKGSRGEGMTFYSAEEVTIAYEEKAIDLHAIIKVKVEDIDENGDYFNHIIETTVGRVLFNEFVPRQAGYVNQILTKKSLRSIITDVFNKSGNAITVKFLDDIKNLGYTMAYRGGLSFNLGDVIIPEDKAEIVGNGYQEVEEVINNYNMGFITNNERYNQVIDIWTHANAKLTNSVMKTISTDRQGFNSIYMMLDSGARGSKEQIRQLCGMRGLMAKPQKSGSTGSQIIENPILANFKEGLSVLEYFISTHGARKGLADTALKTADAGYLTRRLVDVAQDVIISEDDCGTLRGLVASDVKNNEEVVASLFERIVGRTTVHDIFHPLNGELIIKSGDEITEEIAKVIEDSPIETVEIRSVLTCESKVGVCAKCYGRNLATGKKVQKGEATGVIAAQSIGEPGTQLTLRTFHVGGIAGNISAQSTVESKYDGYCEIEELRSVSYKDDEGNDVEVVVSRLAELKIIDKNTKIPLSTHPLPYGCKLYVKNGQEIRKGAMICDWDPFNGVIITEFDGKVEFENLIEGITFREESDEQTGYSERVIIETKDKTKNPTLKIMDDAGEMIRSYNLPVGGHISVDNGQEVKAGKILVKIPRAAGKAGDITGGLPRVTELFEARNPSNPAVVSEVDGEVSLGKIKRGNREIIVTTKNGDVKRYLVPLSKQILVQENDYIRAGIPLSDGATTPSDILAIKGPTAVQEYILNEVQDVYRMQGVKINDKHFEIIIRQMMRKVEIVDPGDTRFLEKQIVDKNEFMSENDWIYNKKVVVDPGDAEGLKAGQIVSSRRLRDENSQLRRKDKKLVESRDAIPATSSQILQGITRAALQTRSWLSAASFQETTKVLNEAAINGKMDYLDGLKENVICGHLIPAGTGLKEYKNLVVGSKSEYDRLVDMRHSDNS
>NZ_CP007451.1|WP_038556000.1|1047932_1051742_-|DNA-directed-RNA-polymerase-subunit-beta
MSVQAKIERINFSSTQTRFDYPDFLEVQVKSFKDFFQLKTTPDKRKGEGLYRVFEENFPISDTRNNFVLEFIDYQVDPPRYSIDECIERGLTFSVPLKAKLKLYCTDPEHEDFDTVVQDVYLGTVPYMTNRGTFIINGAERVIVSQLHRSPGVFFGQSLHANGTKLYSARIIPFKGSWIEFATDINSVMFAYIDRKKKLPVTTLLRAIGYESDKDVLEIFDLADEVKVSKSGLKKVVGRRLAARVLKSWVEDFVDEDTGEVVSIERNEVIIDRETDIEEDHIEEILESGVKTILLHKEDQNQQDFAIIYNTLQKDPCNSEKEAVLHIYRQLRNAEPPDEATARDVIDKLFFSDKRYDLGEVGRYRINKKLGIDVDMENRVLTKVDIIEIIKNLIQLVNSKTDVDDIDHLSNRRVRTVGEQMYNQFGVGLARMARTIRERMNVRDNEVFTPIDLINSKTLSSVINSFFGTNALSQFMDQTNPLAEMTHKRRMSALGPGGLSRERAGFEVRDVHFTHYGRLCPIETPEGPNIGLISSLCVFAKINPLGFISTPYRKVENGIVDLSETGSVYLTAEEEEGKIIAQANAPIAEDGKFVNEKVKARLDGDYPVIDAGEVELMDVGPNQIASVAASLISFLEHDDANRALMGSNMMRQAVPLLRPEAPIVGTGLEANVAKDSGVMICAEGDGVIEFVDAKQIIVRYDMTEEDRFVSFDPEVVTYNLQKYTKTNQGTTVDLKPIVVKGQRVTEGEILTEGYATDKGELALGRNLQVAFMPWQGYNYEDAIVISERIVREDVFTSVHVDEYTLEVRDTKRGVEEFTSDIPNVSEEATRNLDENGLIRVGANVKPGDILIGKITPKGESDPSPEEKLLRAIFGDKAGDVKDASLKASPSLKGVVIDKKLFSRVAKDKKGKATKTLLDQIDEKLEKDISALRIKLEDKLFTLVNGKTSQGVKDYYGTEFIPKGVKFTLKQLQELDYLNIDPSKWTTDKAKNDLIFRLVNNFIMKQKEAESVSRRERYNVTIGDELPAGIIQLAKIYIAKKRKLQIGDKMAGRHGNKGIVSRVVRAEDMPFLADGTPVDIVLNPLGVPSRMNLGQIYETVLGWAGKELGLKFATPIFDGASLDEVSEYTDKAGIPRYGETRLINGETGEPFDQPATVGIIYMLKLGHMVEDKMHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAFGASHILQEILTVKSDDVMGRAKAYEAIVKGEPMPQPGIPESLNVLLHELRGLGLSVRME
>NZ_CP007451.1|WP_038556003.1|1051846_1052224_-|50S-ribosomal-protein-L7/L12
MADLKQLAEELVNLTVKEVNELAGILKDEYGIEPAAAAVAVAGPAAGGGEEAAAEQTEFDVILKAAGGSKLAVVKLVKELTGLGLKEAKAVVDEAPKALKEKVSKDEAEALKAQLEEAGAEVEVK

Crispr_ID: NZ_CP007451_3

• CRISPR_ID: NZ_CP007451_3
• CRISPR_location: 1761539-1761625
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP007451_3

Consensus_repeat	Method
TCATTGGTCACTGGCCATTGGTT	CRISPRCasFinder

spacers of NZ_CP007451_3

>3.1|1761562|41|NZ_CP007451|CRISPRCasFinder
ATTGGTTATTGATTATTGGTTATTGATTATTGTATCTTTCA

CRISPR arrays and Neighbor proteins around NZ_CP007451_3

CRISPR arrays

The CRISPR arrays of NZ_CP007451_3

>merge|NZ_CP007451|3|1761539-1761625|CRISPRCasFinder
CTATTGGTCATTGGTCACTGGCCATTGGTTATTGATTATTGGTTATTGATTATTGTATCTTTCATTATTGGTCACTGGCCATTGGTT

>NZ_CP007451|3|2|1761539-1761625|CRISPRCasFinder
CTATTGGTCATTGGTCACTGGCC	ATTGGTTATTGATTATTGGTTATTGATTATTGTATCTTTCA
TTATTGGTCACTGGCCATTGGTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007451.1|WP_139178053.1|1758739_1759009_-|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl|CDD|376620
NZ_CP007451.1|WP_038557069.1|1757037_1757784_-|metal-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224046
NZ_CP007451.1|WP_038557095.1|1772222_1774061_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|238657
NZ_CP007451.1|WP_038557061.1|1752843_1755150_+|glucosamine-6-phosphate-isomerase	unknown	unknown	gnl|CDD|235005
NZ_CP007451.1|WP_051567687.1|1751528_1752746_+|ROK-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224851
NZ_CP007451.1|WP_081804790.1|1760271_1761465_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|197666
NZ_CP007451.1|WP_038557097.1|1775561_1776413_-|gliding-motility-protein-GldN	unknown	unknown	gnl|CDD|274628
NZ_CP007451.1|WP_081804791.1|1764287_1767926_+|hypothetical-protein	unknown	unknown	gnl|CDD|379155
NZ_CP007451.1|WP_038557087.1|1767877_1769221_+|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|214795
NZ_CP007451.1|WP_038557071.1|1759218_1760196_+|ROK-family-protein	unknown	unknown	gnl|CDD|224851
NZ_CP007451.1|WP_051567686.1|1750233_1751334_-|hypothetical-protein	unknown	unknown	gnl|CDD|213996
NZ_CP007451.1|WP_051567688.1|1757783_1758659_-|zinc-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238500
NZ_CP007451.1|WP_038557089.1|1769309_1771238_+|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|341066
NZ_CP007451.1|WP_038557079.1|1762042_1763092_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038557093.1|1771761_1772163_+|nickel-responsive-transcriptional-regulator-NikR	unknown	unknown	gnl|CDD|179855
NZ_CP007451.1|WP_038557067.1|1756226_1757036_-|metal-ABC-transporter-permease	unknown	unknown	gnl|CDD|224033
NZ_CP007451.1|WP_038557082.1|1763201_1764257_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038557091.1|1771240_1771645_-|OsmC-family-protein	unknown	unknown	gnl|CDD|376823
NZ_CP007451.1|WP_038557063.1|1755163_1755943_+|glucosamine-6-phosphate-deaminase	unknown	unknown	gnl|CDD|179028
NZ_CP007451.1|WP_051567690.1|1774095_1775457_-|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl|CDD|274629

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP007451.1|WP_139178053.1|1758739_1759009_-|membrane-protein-insertion-efficiency-factor-YidD	gnl|CDD|376620	pfam01809, Haemolytic, Haemolytic domain. This domain has haemolytic activity. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	1.90568e-33
NZ_CP007451.1|WP_038557069.1|1757037_1757784_-|metal-ABC-transporter-ATP-binding-protein	gnl|CDD|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	1.26344e-82
NZ_CP007451.1|WP_038557095.1|1772222_1774061_+|TonB-dependent-receptor	gnl|CDD|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	6.47648e-64
NZ_CP007451.1|WP_038557061.1|1752843_1755150_+|glucosamine-6-phosphate-isomerase	gnl|CDD|235005	PRK02122, PRK02122, glucosamine-6-phosphate deaminase-like protein; Validated.	4.79133e-39
NZ_CP007451.1|WP_051567687.1|1751528_1752746_+|ROK-family-transcriptional-regulator	gnl|CDD|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.37553e-50
NZ_CP007451.1|WP_081804790.1|1760271_1761465_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	4.90907e-17
NZ_CP007451.1|WP_038557097.1|1775561_1776413_-|gliding-motility-protein-GldN	gnl|CDD|274628	TIGR03523, hypothetical_protein_P700755_05002, gliding motility associated protien GldN. Members of this protein family are exclusive to the Bacteroidetes phylum (previously Cytophaga-Flavobacteria-Bacteroides). GldN is a protein linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae and Cytophaga hutchinsonii. Knockouts of GldN abolish the gliding phenotype. Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Bacteroidetes with members of this protein also include those which are not believed to express the gliding phenotype, such as Prevotella intermedia and Porphyromonas gingivales.	1.54333e-68
NZ_CP007451.1|WP_038557087.1|1767877_1769221_+|T9SS-type-A-sorting-domain-containing-protein	gnl|CDD|214795	smart00736, CADG, Dystroglycan-type cadherin-like domains. Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions.	4.75118e-08
NZ_CP007451.1|WP_081804791.1|1764287_1767926_+|hypothetical-protein	gnl|CDD|379155	pfam13385, Laminin_G_3, Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	3.42217e-27
NZ_CP007451.1|WP_051567686.1|1750233_1751334_-|hypothetical-protein	gnl|CDD|213996	cd12112, PHP_HisPPase_Chlorobi_like, Polymerase and Histidinol Phosphatase domain of Chlorobi like. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. Chlorobi PHP is uncharacterized protein. HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to produce histidinol. The HisPPase can be classified into two types: the bifunctional Hisppase found in proteobacteria that belongs to the DDDD superfamily and the monofunctional Bacillus subtilis type that is a member of the PHP family. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.	3.54578e-125
NZ_CP007451.1|WP_051567688.1|1757783_1758659_-|zinc-ABC-transporter-substrate-binding-protein	gnl|CDD|238500	cd01018, ZntC, Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. They are comprised of two globular subdomains connected by a long alpha helix and bind their specific ligands in the cleft between these domains. In addition, many of these proteins possess a metal-binding histidine-rich motif (repetitive HDH sequence).	2.03582e-99
NZ_CP007451.1|WP_038557089.1|1769309_1771238_+|T9SS-type-A-sorting-domain-containing-protein	gnl|CDD|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	2.64609e-134
NZ_CP007451.1|WP_038557093.1|1771761_1772163_+|nickel-responsive-transcriptional-regulator-NikR	gnl|CDD|179855	PRK04460, PRK04460, nickel-responsive transcriptional regulator NikR.	2.13831e-40
NZ_CP007451.1|WP_038557067.1|1756226_1757036_-|metal-ABC-transporter-permease	gnl|CDD|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	4.08689e-63
NZ_CP007451.1|WP_038557071.1|1759218_1760196_+|ROK-family-protein	gnl|CDD|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.07762e-62
NZ_CP007451.1|WP_038557091.1|1771240_1771645_-|OsmC-family-protein	gnl|CDD|376823	pfam02566, OsmC, OsmC-like protein. Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation.	1.77225e-15
NZ_CP007451.1|WP_038557063.1|1755163_1755943_+|glucosamine-6-phosphate-deaminase	gnl|CDD|179028	PRK00443, nagB, glucosamine-6-phosphate deaminase; Provisional.	2.89351e-158
NZ_CP007451.1|WP_051567690.1|1774095_1775457_-|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl|CDD|274629	TIGR03525, lipoprotein_putative, gliding motility-associated lipoprotein GldK. Members of this protein family are exclusive to the Bacteroidetes phylum (previously Cytophaga-Flavobacteria-Bacteroides). GldK is a lipoprotein linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae. Knockouts of GldK abolish the gliding phenotype. GldK is homologous to GldJ. There is a GldK homolog in Cytophaga hutchinsonii and several other species that has a different, shorter architecture and is represented by a separate model. Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Bacteroidetes with members of this protein family appear to have all of the genes associated with gliding motility.	3.01984e-118

Protein sequences

>NZ_CP007451.1|WP_081804790.1|1760271_1761465_-|helix-turn-helix-transcriptional-regulator
MLRDLVVYTPMYVTFFWCIVLLIPNSKNNRAKHFLGFFMLAAFLLYLCHAIFFKGLFKAYLWMDPVYTFVSLSVYPLYYWYIKLLSIETAYKWYNLRMLLPAAILFCCSVGAYLLMTSAEQDYYLTSFLLKKQGFQSGSFAVLLQEIFYVSGRIIFIIQVFFFLIHGRNLILRYNSKIANFYSNLNNRTILWVKTLLYSLVLTSGMSIIFTIIGRTQFMDSTVILFIPSSIFSILLFFIGLQGYMQNHTVVDFLVEENMDAEISSNKVFNQDKLKRKLLELFAEQKPYRNMELKITQVSKELSTNRTYVSNLINNEFLCSFSDFVNNYRVDEAKELLADPAYDCRSLESVAELVGFGSLNTFIRVFKQTVGVTPGRYRSKIVQAKKSSPTPPKGKVL
>NZ_CP007451.1|WP_038557071.1|1759218_1760196_+|ROK-family-protein
MKKVAIGVDIGGTNTAIGVVDADGNVMVKDNISTPSHGDIDQYISDLAAAIKELIKSVKLLNENLEVFGIGIGAPNGNYYSGTIEYAPNLSFKGVVRLVELLRAHFPDMEALALTNDANAAAIGEMIYGGAKDMKNFVMFTLGTGVGSGIVVNGDLVYGHDGFAGECGHTTLIPGGRLCGCTALGHLEAYCSAPGMKRTAFELMVQYNATDSILADKSFNELDSKMIYDAAEKGDKIALEVFEKTGAWLGQGLADTVHHLSPEAVFLFGGPTAAGDYIFKPTKKHMEKHLLPIFKEKIKILPSELKPGDAAIVGASALAWKELEK
>NZ_CP007451.1|WP_139178053.1|1758739_1759009_-|membrane-protein-insertion-efficiency-factor-YidD
MRTVGKAILKFLGWILLIPIYIYRYGISPLTPASCRHIPTCSEYAVKAIKIHGPFKGFVLTVRRLSKCHPWGTHGYDPVPPKEPGAKKF
>NZ_CP007451.1|WP_051567688.1|1757783_1758659_-|zinc-ABC-transporter-substrate-binding-protein
MKRTILLLVLATLFASCGNQKKADKSAAADVVTVSILPQKTFVEKIAGDDFEVNLLIPPGSSPAAYTLLPSQLKDISRSAIWFRIGYIGFEHSWADKIEQANTKMKVVNISEGLDLIADKMEQHGDHVHIDGVDPHVWLSPTMVKQMAKVILDELSALKPEKAADYQRNYMRFAEECDQLNSDLKNQLKDYAGRKFIVFHPSLSYFAREYGLEQYSLESGGKEPTPQHLREVVDIAKAEGIKVVYIQSEFDREHARVFADEIGGQIVQVWPLNPEWEENLRSMTQTLIDNF
>NZ_CP007451.1|WP_038557069.1|1757037_1757784_-|metal-ABC-transporter-ATP-binding-protein
MDPLIKIENLSVAYDKVPVLENVNLEIHENDFLGVIGPNGGGKTTLLKAILGLKKPESGKIHFSKEMSGRKKPIGYLPQVRHIDRKFPITVFDVVLSGGIMQNRQNAKSIAKDKAEALLEEMGVIGIRNKAIGELSGGQMQRVFLCRALLSDPKLLILDEPDTFVDNRFEGELYEKLEKLNEELAILLVSHDVGTITSCVKSIACVNKYLHYHPSNVISQEQLANYNCPIQIISHGEIPHTVLKHHHQ
>NZ_CP007451.1|WP_038557067.1|1756226_1757036_-|metal-ABC-transporter-permease
MSAILELFSYDFFQKAFLAAVFASISCGIIGAYIVSRRIVFISGGITHASFGGIGLAFFLGFNPLLGAVLFAVLSALGIQFFTKVAEIREDSSIAIWWSLGMALGIIFVFLTPGYTPNLMSYLFGNILTVTTSELWWMFMLNTVIVLFFAVFLRKILYIAFDEEFARTAGLPVALFNYLIMVLIALTVVLNIRVVGIILILSLLTIPQATANLFTNDFKRLLVYSSLFAFVGTIAGLFISYFLNIPSGAAIIFTLVVIFGLLRLVKSFV
>NZ_CP007451.1|WP_038557063.1|1755163_1755943_+|glucosamine-6-phosphate-deaminase
MKLVIHNNYDELSIWAANHIAERISDFAPTAEKPFVLGLPTGSTPLGTYNALIDLYQQGKVSFKNVVTFNMDEYVGISEDHPESYHSFMFENFFNHIDIPKENINILDGNAADLNAECERYEAKIESYGGIELFMGGMGADGHLAFNIPGSSIQSRTRLVDLNYDTIMANSRFFDNDLNQVPKQALTVGVQTVLDSKEVLVLVNGYKKARALQNVVENGINHMWTLSALQMHPNGIIVCDEDATMELKVGTVKYFKESV
>NZ_CP007451.1|WP_038557061.1|1752843_1755150_+|glucosamine-6-phosphate-isomerase
MKVSFTKVEEAFFEETKSKKVSTRIPYITTESFPKLGLLSALSFLEWASKNPNGVVSLPTGKTAQYFLDFTHLLLDNWNNKKGKDFLEKYGLADVKKPELGELSFVQMGEFFPINPEQHNSLYNYAQKQYIEGLGFKKENALLINSEEIKLAEGKHYSEIFPDFKIDLSLRYREAKTHQEQLQQESIFKIDNWCTAYESKIRKKGGIGFFLSGIGPDGLIAFNTRGSDHFSSTRLTETNFETQAITAADLGGIEVSKNRLVITIGLGTLTFNPDNKAIVYAAGEAIADTIKASLENEPSVTYPATALQKLKNARFYLTEGAAVTLKDSIEAYYTGSPWNHQKTERAVIELCKKINKFGSKLDLEDLKADKYCSMIPDLNENTVQSVIDSILAKLQKGMQKEVNQTYYHTGPHHDDIMLGIMPATNRQSRDASNELHFSVATSGFTAVTNTFLYDLLVETKDLMNQGKIEMINFPDFFKDGYKYKWDKDIYHYLDNIAAQDEEEKRRGVCHRVIRALVSIWKIKNEEELRETIFEILTSLRNTYDGGKNPPKIQKLKGMIREFEEELVWAHYGIMVKNVHHLRLGFYSGESNYDKDILPILEDFRKYKPTVISLAMDPQGSGPDTHYKVLMAIAKAVEDWSKEEDLSKLRIVGYRNVWFKYNPWDVEVIVPVSLNSLATLDKSFSECYITQVNASFPSYQLDGKFSDLTQRVWFDQHKQIQLLLGKNFFYQNESPLLRATHGVIYHRELTVEQFLEEAQKLGKAMENIL
>NZ_CP007451.1|WP_051567687.1|1751528_1752746_+|ROK-family-transcriptional-regulator
MEKLFKTTGNQSQAVELKKIAQKKQILRSIYFNGPLSNSDLARQIKLSTPKINSLLLELIEDQLVTELGRGDSSGGRRPNIYGLIENGFYVVGITINVARTIISIFNSCNQEVSGPHYFPIKMSSDINIFNQVNAELEKVIKDSNIDREKILVAGLELPGLINQKEGINQTYFPEEKDLFSKLQKIFGIPVFISHDAKLRTFAEQYFGLAKGKKNVLMLQADWGLGLGIIINGRLYTGKSGYSGEFGHLPLADNGVLCVCGKQGCLETIVSANAIARQAREGIEQGHSSLIKELVKDDLNKIDISTVIQAANSGDQFAISLFSEVGKWLGRGMAYLIQIFNPELIIIGGQVAVASQFILAPIQQAIHTFSNRDISNETQILFSELGTKAGTMGAAAYALERISKK
>NZ_CP007451.1|WP_051567686.1|1750233_1751334_-|hypothetical-protein
MMKKFGFIIVLLVVSSGLLYAQSRRIINIPNISGYQTLKCDLHMHTVFSDGTVWPTVRIEEAWNEGLDAISITDHIEYRPHSIDVVADHNRSYDLAKPLADQSDILLIKGAEITRSMPPGHFNALFITNANLLELDDVQDAVKEARDQGAFLMWNHPCWDAQQPDSVLWWDEHSYFFENDMLHGIEVYNWEFCPEALDWANEKMLTMLGNSDVHGPMDVNDGHRPLTLVFAKSRTIGGIKEALFDGRTAVYFDNTIVGRSEFLEPLFFQSLEFKKTPLKLKNKESKVVKITNNSDVDYELELVQPGVGFDAPETITLKAHHVSALSLSGNSDEVANSGSLDVYYRVNNLLTGVDDPLVVTFTFRNN
>NZ_CP007451.1|WP_038557079.1|1762042_1763092_+|hypothetical-protein
MKKLYFLPFLFLAITTFAQKQFVVQNGTAQTFDEINAAIEAASAGDTIYLPGGGFSISAQVDKTLHWRGVGHYPDSTSATGFTQILGSPTFSGNCDNSTFEGIFFQSSVTFGSNDNECTGVIIKRCRVNSTLTLRTTTDVSSGYPNLNVQVFESVLAHIDANNGMNIRFEKNLIFGLMYDFYQSSFNHNSFNVNHSSMVRNCKNCQFTNNVFSYHATFDGGTTNCNFENNIFQQSGMPFNSTTSTFTSSGNIYNTGLGLYVSIVGNNYTFDYANDYNLNDITGTAEDGTTGVSIKNSGIDGTDPGVYGTSLPYKEGAVPYAPHIQSANIVNDAVNGELGVQIKVVAQER
>NZ_CP007451.1|WP_038557082.1|1763201_1764257_+|hypothetical-protein
MKKIIILPFLFLATLSWGQAQFVVQNGTKTEVYNNINTAITNAVAGDTLYIPGGGFTITNTTIDKTLHWVGHGHYPSETGATMQTRINSALNFTGNCDNSSFEGIFFTSEVSFGSADNEAENILMKRCRVLSNLSLRTVTTGNPDLNFQISECVLYTLFGNYGINCLIEKSLIFNRIHYFVQSQFSHNSINVSSSNRVIYLCTSCIFVDNVFGYEGGLYNSFSCVINNNVFAGSLPFTPVTDINGNDGFNNIYNVGSANVYSDVSQSVNPYTFAYENDYTLKGGSTGTDQSGASGISISGTATDGTNAGIYGTATPYKTIPYYPHINTANIATQAVNNELGIDINAEAQSR
>NZ_CP007451.1|WP_081804791.1|1764287_1767926_+|hypothetical-protein
MRRLIYLLIWLLLPAWLSAQTNITQVEYWYDSDYATANRQTVSGSSVNYTDLLDVSSFEPGLHTVTFRFQDDRGVWGSVLTKFFTYYPNTSPGINLVTDVEYWFDGNYSTTIETSLTSGASADWNTLLDVTSLNNGLHTVSFRFKDNRGIWGSPLIRFFKKEASTGLQQIVALEYWFNNDYANKKSDSFAATALLNINEMLDVSSLGIGFHFVNFRMKDKSGKWGPVASWFFTKENHETLPQLHQITSLEYWYDGDYSNLQTSSVPTTSIMTLDTDFDVSGLTDGLHYVSTRFRDEAGNWSPAYSKFFAKYPDENGVDLHEITELQYWYNGDYSTVYTGTAPSASQLNLNTLLNATALNDGLHQVSIRFKDESGKWSPAFSRFFAKYPIESAANMHNLVAVEYWIDGDNSGAERTSITPGAEYVLNTQLNVSALADGLHLITYRFQDETGVWSPAYSELFSKYKDEVIATGNKITGYRYWADNQIGSAIETTLATPVKLLDIDKLIDVSSLPGGTHDISFQFRDSSGQWSSAYTEPYTQDYNPRGTITVGTDPACTQSLVTFTAETIDVDSIYWDFGDATAVIGHTTAEEAYHTYSNAGDYSISAILKQNSSGNSSTIYTSITVNQSYGVSVVAPKNLIAYYPLDGDAVDAGTFGHDGTVFEALPTSDRNGNANQAFYFDGINDYIDLGDWENGGAMSFTFWARWDAFNNYSRIIDLGNGSSSNNIIVANYQTGSNIFFSTYNNSTEIKYYTPALTLGQWDYFAATIDDQGEIKVYKNGAFIGNKTNANVPNILTRTAQYIGKSNFSADGYFKGAIDELKIYNKALSAEEIQLDYEGTEGSNLPPVEAEICANEIPYNFGSQLLSASGTYYANFPAVTGCDSIVQLNLTIHPVYASSDMPDPTNLIAYYPFYGNALDESGNGHNGIANGATLVEDRNGNANSAYLFDGNDGIDVPHSDGLNRTGELSVSCWIKPTVLQNAMIFGKSNYTSATNYLLRVQSDGNIQWEYNGFLNTTTKPLQANNWYHIVVTADNPGAHRKVYVNGQLIAETTTSSGPFGSVTNPLTFGYASRGAEYFQGAIDDVRFYNKELTDAEITALFRESDLIVEKEICSTETPYIFGTQQLTTSGIYTETFQSQYGCDSTVTINLLVNPSYSISLTDSRILFAKANCLMSLAANCLFLLALIPKPLLRQVVATAWLHWIFGFIKATISN
>NZ_CP007451.1|WP_038557087.1|1767877_1769221_+|T9SS-type-A-sorting-domain-containing-protein
MVALDLWIHKSYNIKLNESVKQTELPYIFGDQPLYESGDYTNSLFTAFGCDSIITLHLLVEDNIPPVVICNAINVELLTDGTYTLTEADKKAITQETTDNVSAYEDLDIQVSTSVFSCEHLGENTVKVTVSDTAGNEASCQTTISVNIGISPPTINEIPDLTINEDDSVSITLSGISGGNKCETRKVSIEATGSNTNLVEKLSVKYFPLDTVAILDIVLIPDQSGTDIIVVEVTDTLGNITTESFTITVNTVNDPPTLIHAMEDQLMDTGDTLTVSINKLDGNIFSDIDDNSLAYASSMENEAFPDWITESENEDIYNLIFTPSSADTGCFNIIVETSDPAGETVTDTFEICVMSVVGIDKLDRNKFEIKLYPNPSKGTVNIDFTNPPTGEIELLVTDILGGQILYKRYQSNERIVFDLSRHISGSYLVILKINEQRIVRKLILDKK
>NZ_CP007451.1|WP_038557089.1|1769309_1771238_+|T9SS-type-A-sorting-domain-containing-protein
MIRCANILLFLFFGLNAIAQENKLFISDKIALEESRSFRLKSSFIESQNYYLTDFVYQRMVWQVDPAVRYISGKVSTHFKSKTALLNTIEFDLSDSLTVDSVFVGDHSAPFTHQNNKVEIDLPEPLLLNQLDSASIYYHGIPPKSGLGSFETSSHGTEFTPVLWTLSQPYGAREWWPCKQSLADKIDSIDVIVTTPEKYKTASNGILVSEQLNNTTRTMHWKHRFAIATYLVAIAVTDYERYSDYLETENGDSIEILNYVYPEDLEDAKGKTPVTAEIIQLYQNLVGDYPFAAEKYGHAQFGWGGGMEHQTMSFMGNFGYGLIAHELAHQWFGNYITLGSWQDIWLNEGFATYLTGLSYENIETDWWPVWKQVYSDQVKEEPDGSVYVNDTTSVARIFSSRLSYAKGGYLLHMLRWVIGDDAFFQGLKNYFTDPAVANGFARSEYVINHFEQVANTSLTEFFNDWLYGEGYPIYTASFKPGDEEKTLITLSQSTTHESVDFFEMPVPVRLYNAGRTDSLDVRLNHTSNQQQFLVNSGFHVAEAVIDPDLWLISATQEIVGVPAELKTQTIAIFPNPATTEISLRIPSSKEITGIRIFEMNGAEVKHFSVQPDKINISDLAPGIYLVKAELAGGTFQGRFIKH
>NZ_CP007451.1|WP_038557091.1|1771240_1771645_-|OsmC-family-protein
MTTIKTIYLGELRTENEHLQSGNKVITDAPTDNRGKGEYFSPTDLLATALGSCIMTIMGIKARDNGIDIEGTQVDVTKIMASDPRRVAEVVVEFTFPAKNYTNEEKQLVESVAGVSPVPLSLHPDLVQTIKFNW
>NZ_CP007451.1|WP_038557093.1|1771761_1772163_+|nickel-responsive-transcriptional-regulator-NikR
MAVSRFGVSLDEELLEALDKYVEDNAFANRSRAIRHLIEKNLVEEKWKCDNIVAGAVIIVFNHEKKDILKKSAEIQYEHKEFILSSQGFYLNELNYMEIIAVKGPSRKLTEISEQLISLKGIQHGKLVMSKAE
>NZ_CP007451.1|WP_038557095.1|1772222_1774061_+|TonB-dependent-receptor
MRIFIFSFFILLITQGIASAQMHYETNDTIKINEVVVTGTQVQVNRNNVPMAVSVVNRTQIEESDESAILPILNGRVPGLFVTERGVTGFGVAAGSAGQISIRGIGGSPTTGVLMLIDGHPQFMGIMGHPLPDSYVASDVERVEVIRGPASILYGSNAMGGVINIITKKQDTEGFNGNARISYGSYNTQKYMGSVGFKKDKFSVFISANHDQTDGHRPNSDFKITNGYVKLGYQISDHFNASADFSVAAFDASDPGPDTLNASPGETIDILRGYGSLSLRNNFEKASGALKLFYNFGEHEITDGFHSNDHNYGLNLYETFQLFTGNNLTAGLDLMNYGGEAENTLAMGGKGLTFADTTITEIGAYLFSQQSIGEKLIINAGLRYHNHSEYGSVWIPSIGFSNSFSPSTTWKGTISKGFRSPTMRELFMWGPNPNLNPESIWNYETGIIQAFFDRRMQVELTAFLVKGDNLIVNTGQPNGYQNTGEVSNKGIEFSLDASPTKQLTLNATYSYINMKNPVYATPEHHLFVNASYRIKKLLLVANMQHISGLDNDPTPVTNQESYSLLNAKASYSLTKNVKLYVSAENLLSTNYAVNRYYTMPEITVFGGLSLMF
>NZ_CP007451.1|WP_051567690.1|1774095_1775457_-|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MRKAITYLFILALLFASCRNESNKYLKLGKGTSEKWFEPTPYGMVYVPRGAYNLGPNDDQLYAITQNRTVSSEAFWIDDTEITNDEYRQFVYWVRDKKARELLGQTYTDFLITEDKYGAPLEEPKINWDERIEWDDPEYQMAMEELYVPEYERFGYKKEIDTRKLVYEYYWVDYKQAAKRSNAYNYETQRYEGSVVNSDGEVVPIENRSSFLMHESVPVYPDTLCWIRDFAYTYNEPFTIKYFSHVGFDDYPVVGVTWNQARAFCNWRNNLRDFAFSHSAEAPAHEYRLPTESEWEIAARGGMHNTMYPWGSYYTRNVSGCFVANFKPLRGNYVADSPTTTTTMKVGLFDPNPYGVYDMAGNVAEWTSTAFFEAGYEAIDDYNPEIQYNARPDDPAVMKRKVVRGGSWKDIAYFIQSGTRSFEYQDTAKSYIGFRCVRTSFRDDLGGGRSIQE
>NZ_CP007451.1|WP_038557097.1|1775561_1776413_-|gliding-motility-protein-GldN
MKKIVVYIGIVVFALGIMHKSADAQIVNGAYKQNDIYEKKPMPLVPVREADVFWQKTLWRVIDLREKMNIPLYYPTIPIADRSNLISLLLKGIESGQITPYDAQADDDFKIPMSFAQVKARFGAEARTEEKIDFDTGERTQVQVQGEIRPTEIKQYMLKEQWYFDKQTSTLNVRILGICPIREYMREGDTSGQPQRQKVFWIYYPEARPLLATNVVQNPYNEARQQSFDDLFIKRMFNSYIVQESNIYNNREISSYLVGKDAMLESKRIEDEIFNYEQDLWEY

Crispr_ID: NZ_CP007451_4

• CRISPR_ID: NZ_CP007451_4
• CRISPR_location: 2018736-2018903
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP007451_4

Consensus_repeat	Method
TAGCAATACGCGCTTAGCGGTTTCAACCGCTTAGCGCATC	PILER-CR

spacers of NZ_CP007451_4

>4.1|2018776|15|NZ_CP007451|PILER-CR
TCACAAAATAGATGG
>4.2|2018831|68|NZ_CP007451|PILER-CR
CAAAATGATTAACAAGGGATCCGATCCGTATAAGTTGACGTAGATACGGATCGGATCCTTTATTTTGG

CRISPR arrays and Neighbor proteins around NZ_CP007451_4

CRISPR arrays

The CRISPR arrays of NZ_CP007451_4

>merge|NZ_CP007451|4|2018736-2018903|PILER-CR
TAGCAATACGCGCTTAGCGGTTTCAACCGCTTAGCGCATCTCACAAAATAGATGGGCATCCAAAATGATTAACAAGGGATCCGATCCGTATAAGTTGACGTAGATACGGATCGGATCCTTTATTTTGGTAGCAATACGCGCTTAGCGGTTTCAACCGCTTAGCGCATA

>NZ_CP007451|4|1|2018736-2018903|PILER-CR
TAGCAATACGCGCTTAGCGGTTTCAACCGCTTAGCGCATC	TCACAAAATAGATGG
GCATCCAAAATGATTAACAAGGGATCCGATCCGTATAAGT	TGACGTAGATACGGATCGGATCCTTTATTTTGGTAGCAATACGCGCTTAGCGGTTTCAACCGCTTAGC
GCATA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007451.1|WP_038557448.1|2027523_2028033_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_139178004.1|2006893_2007739_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038557446.1|2024875_2025646_+|aminoglycoside-6-adenylyltransferase	unknown	unknown	gnl|CDD|376187
NZ_CP007451.1|WP_038557449.1|2033214_2033658_+|IS200/IS605-family-transposase	unknown	unknown	gnl|CDD|376616
NZ_CP007451.1|WP_038557440.1|2017504_2018410_+|glycyl-radical-enzyme-activating-protein	unknown	unknown	gnl|CDD|274163
NZ_CP007451.1|WP_038564288.1|2009319_2010168_-|aldo/keto-reductase	unknown	unknown	gnl|CDD|381326
NZ_CP007451.1|WP_038557445.1|2023166_2024390_-|MFS-transporter	unknown	unknown	gnl|CDD|340863
NZ_CP007451.1|WP_051567717.1|2010878_2011754_-|glycine-betaine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270357
NZ_CP007451.1|WP_081804947.1|2015075_2017436_+|glycyl-radical-protein	unknown	unknown	gnl|CDD|153086
NZ_CP007451.1|WP_038557447.1|2026140_2027361_+|tetracycline-resistance-MFS-efflux-pump	unknown	unknown	gnl|CDD|340946
NZ_CP007451.1|WP_038557442.1|2020827_2021124_+|TM2-domain-containing-protein	unknown	unknown	gnl|CDD|377473
NZ_CP007451.1|WP_038557438.1|2011766_2012687_-|universal-stress-protein	unknown	unknown	gnl|CDD|238182
NZ_CP007451.1|WP_051567718.1|2012706_2014368_-|BCCT-family-transporter	unknown	unknown	gnl|CDD|376718
NZ_CP007451.1|WP_038557441.1|2019101_2019854_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038557443.1|2021471_2021915_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038557437.1|2010237_2010435_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_051567716.1|2008465_2009065_-|phage-integrase-SAM-like-domain-containing-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038557444.1|2022273_2023161_-|Mph(E)/Mph(G)-family-macrolide-2'-phosphotransferase	unknown	unknown	gnl|CDD|270701
NZ_CP007451.1|WP_051567719.1|2028228_2032956_+|PAS-domain-S-box-protein	unknown	unknown	gnl|CDD|236842
NZ_CP007451.1|WP_051567715.1|2007747_2008380_-|hypothetical-protein	unknown	unknown	gnl|CDD|271185

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP007451.1|WP_038564288.1|2009319_2010168_-|aldo/keto-reductase	gnl|CDD|381326	cd19100, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	8.98478e-95
NZ_CP007451.1|WP_038557440.1|2017504_2018410_+|glycyl-radical-enzyme-activating-protein	gnl|CDD|274163	TIGR02494, PFLE_PFLC, glycyl-radical enzyme activating protein. This subset of the radical-SAM family (pfam04055) includes a number of probable activating proteins acting on different enzymes all requiring an amino-acid-centered radical. The closest relatives to this family are the pyruvate-formate lyase activating enzyme (PflA, 1.97.1.4, TIGR02493) and the anaerobic ribonucleotide reductase activating enzyme (TIGR02491). Included within this subfamily are activators of hydroxyphenyl acetate decarboxylase (HdpA), benzylsuccinate synthase (BssD), gycerol dehydratase (DhaB2) as well as enzymes annotated in E. coli as activators of different isozymes of pyruvate-formate lyase (PFLC and PFLE) however, these appear to lack characterization and may activate enzymes with distinctive functions. Most of the sequence-level variability between these forms is concentrated within an N-terminal domain which follows a conserved group of three cysteines and contains a variable pattern of 0 to 8 additional cysteines.	4.60768e-116
NZ_CP007451.1|WP_038557445.1|2023166_2024390_-|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.33131e-54
NZ_CP007451.1|WP_051567717.1|2010878_2011754_-|glycine-betaine-ABC-transporter-substrate-binding-protein	gnl|CDD|270357	cd13639, PBP2_OpuAC_like, Substrate binding domain of Lactococcus lactis ABC-type transporter OpuA and related proteins; the type 2 periplasmic binding protein fold. This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to betaine compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine and proline betaine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.61404e-97
NZ_CP007451.1|WP_038557442.1|2020827_2021124_+|TM2-domain-containing-protein	gnl|CDD|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	1.36804e-12
NZ_CP007451.1|WP_038557449.1|2033214_2033658_+|IS200/IS605-family-transposase	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	7.69933e-46
NZ_CP007451.1|WP_038557438.1|2011766_2012687_-|universal-stress-protein	gnl|CDD|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	2.49405e-10
NZ_CP007451.1|WP_051567718.1|2012706_2014368_-|BCCT-family-transporter	gnl|CDD|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NZ_CP007451.1|WP_038557444.1|2022273_2023161_-|Mph(E)/Mph(G)-family-macrolide-2'-phosphotransferase	gnl|CDD|270701	cd05152, MPH2', Macrolide 2'-Phosphotransferase. MPH2' catalyzes the transfer of the gamma-phosphoryl group from ATP to the 2'-hydroxyl of macrolide antibiotics such as erythromycin, clarithromycin, and azithromycin, among others. Macrolides penetrate the bacterial cell and bind to ribosomes, where it interrupts protein elongation, leading ultimately to the demise of the bacterium. Phosphorylation of macrolides leads to their inactivation. Based on substrate specificity and amino acid sequence, MPH2' is divided into types I and II, encoded by mphA and mphB genes, respectively. MPH2'I inactivates 14-membered ring macrolides while MPH2'II inactivates both 14- and 16-membered ring macrolides. Enzymatic inactivation of macrolides has been reported as a mechanism for bacterial resistance in clinical samples. MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	6.71318e-120
NZ_CP007451.1|WP_081804947.1|2015075_2017436_+|glycyl-radical-protein	gnl|CDD|153086	cd01677, PFL2_DhaB_BssA, Pyruvate formate lyase 2 and related enzymes. This family includes pyruvate formate lyase 2 (PFL2), B12-independent glycerol dehydratase (DhaB) and the alpha subunit of benzylsuccinate synthase (BssA), all of which have a highly conserved ten-stranded alpha/beta barrel domain, which is similar to those of PFL1 (pyruvate formate lyase 1) and RNR (ribonucleotide reductase). Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. DhaB catalyzes the first step in the conversion of glycerol to 1,3-propanediol while BssA catalyzes the first step in the anaerobic mineralization of both toluene and m-xylene.	0
NZ_CP007451.1|WP_038557447.1|2026140_2027361_+|tetracycline-resistance-MFS-efflux-pump	gnl|CDD|340946	cd17388, MFS_TetA, Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.61313e-146
NZ_CP007451.1|WP_038557446.1|2024875_2025646_+|aminoglycoside-6-adenylyltransferase	gnl|CDD|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	0.000363678
NZ_CP007451.1|WP_051567719.1|2028228_2032956_+|PAS-domain-S-box-protein	gnl|CDD|236842	PRK11091, PRK11091, aerobic respiration control sensor protein ArcB; Provisional.	6.15358e-73
NZ_CP007451.1|WP_051567715.1|2007747_2008380_-|hypothetical-protein	gnl|CDD|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	7.36495e-27

Protein sequences

>NZ_CP007451.1|WP_038557440.1|2017504_2018410_+|glycyl-radical-enzyme-activating-protein
MKSLLFDIKRYAINDGPGIRITLFMKGCPLSCKWCHNPESQSPDVQKLYTESKCIGAQECIKMCPEDALTLTPKGIVTDYQACTLCGICADVCPTKAIEMSGRTYEIDELMQIIERERVHIEQSNGGVTFSGGEPLMNAEFLMQMLDACGERKLHRTVDTCGFADTDTLLEVAKRTELFLFDLKLMDEAKHKKWTGVSNKLILKNLRLLAESGANINIRVPLIRNVNADHNTLSEMAEFIAALPGKKPVVNLLPYHNIAAGKYNKLGSEYNAMNMDEPSEEEQNRAIAIFEKFGIEAEIGG
>NZ_CP007451.1|WP_081804947.1|2015075_2017436_+|glycyl-radical-protein
MNQRIQRLRKLSVETQESLSIERALITTKFYKENYGKYSEPMMRALNFLEICKQKTIYIGDDELIVAERGPVPKSVPTFPELTCHSVEDFHVLNTRDQQQYTISQEDIDTYEREVIPYWQGRTMRERIFSHVPNEWKRAYEAGVFTEFMEQRAPGHTALDGKIYRKGMLDFKKEIKDHINRLDFLNDPEATEKLEELKAMDVSCDAAIVFAERHAELAKGLAKTESDPKRVAELNRIAEVCRRVPANAPRNLWEAIQMYWFVHLGTVTELNGWDAMNPGHFDQHLTPFYEKELAEGTLTRDEAKELISCFWIKVNNHPAPPKVGITARESGTFNDFTNINIGGVKPDGTDGVSEVSYMMLEVIEELHILQPGNSVHIAKVTPDAFLQAAGKLIRQGHGYPSVFNPDVYIQEMVNQGKTLQDASEGGCSGCIEVGAFGKEAYLLTGYLNVPKVLEIILNNGIDPVTGKVAGIETGDPRSFKSFEELYEAFLKQLNFVVDQKIRVSNYIDQMFAKYAPAPFLSVVIEDCISKGKDYYNGGPRYNTNYIQCTGLATVTDSLSVLKKHVFEDKTFAMETILDAVAKNFEGEEVLRQRILNRTPFFGNDDEYADTIAVQVYNDLLAAIEGKPNTKGECFHLNMLSTTCHVYFGLVLGATPNGRFAGKSISDGTSPSHGCDTHGPTNVIRSLGKLDQSKSGGTLLNLRFVPSLLKRDKDVEKLGHLIRSYFSLGGHHIQFNIVDTATLLAAQACPEDYKDLLVRMAGYSDYFNDMNADLQQEVIDRTQNEVL
>NZ_CP007451.1|WP_051567718.1|2012706_2014368_-|BCCT-family-transporter
MAEKENVPHKGEAHLVSSNKYFDVDGPVFWPAAILIVLFIAVTLIVGQPMNKVFSTIQSSISDYGGWFFVISVNIFLFFVLFIAFSKFGKIKLGGSKAKPEFSKGAWFAMLFSAGMGIGILFWSVGEPINHFIHPPSGEARTVEAARMSLEITFLHWGLHAWGIYALVGMSLAFFTFNKKLPLTISSIFYPLLGRKIYGPWGKAINVLAVVSTLFGLATSLGMGVQQVSAGLAHLFNMPDTITSQVILITVITFAATGSVIAGLSGGVKRLSELNMIIAAVFLLFMIIVGPTLFIFDSFIQNLGGYVQKFFELSTWTETYQQSDWQNDWTVFYWAWWISWSPFVGMFIARISRGRTLKEFVLGVLIVPTLITFLWLSTFGGSAMFLELNSIADVAGAVTDNVATSLYVLLEQFPISTVTSTVGVILVTSFFITSSDSGSLVVDSLTAGGKLDAPVPQRIFWALTEGAVAAVLLVGGGLGALQTAAISTGLPFAIILLFLVWSLLKGLRAEHRDLMEVKREKEHKEYLETISRMLQKRGKTQSVPKQQENKDNS
>NZ_CP007451.1|WP_038557438.1|2011766_2012687_-|universal-stress-protein
MYRLNHILVCLDLTEMDDSLIRYAALLANKIKPESITFLHVMRPFDIPKEILEAYPELDEPVPEIIREELQEKINEQCNPSSNIKVKVAVKEGYTMETIVKFSQENHITLTLMGKKMGYEGTGSIVRKLVGIIPSSVLLVSESVHDRIENLLVRMDFSKASEMALQMAFRLKELTGANVACHHTHKLPVGYFPQVDLEKDEKLSKYVEKISIKEFYKFKKQYKHEADEITFSYSVDAENEEDQILYRKALNTGADMIVIGSSLKSGLADILIDTTSEKLAESDKNIPVLIVNDRSKAITFLKRLFQ
>NZ_CP007451.1|WP_051567717.1|2010878_2011754_-|glycine-betaine-ABC-transporter-substrate-binding-protein
MTQYFSKTSALIVLLAIFSSCNTGTKPEDERSLKIVYTDWSESVAITYLSSILLEEHMDYKVTLKMTDVEEAYREVANSEADVFTDAWLPETQKQYFDQHKENLEMLGITYPEARTGLVVPAYSKLQSVADLKNYAHPIVGIDAGAGVMQKAQAAISKYAPGKTLLTLSEEKMVEQLGDSIQRRKDIVVTGWEPHWIFARYNVRFLDDPDNIFGQKENIYTIATKNLEEEHPNAVRFFERMQLTENQLNSLVYEIRVSENPVDGVKKWMEQNEFVVNQWMKNLTKERIKIY
>NZ_CP007451.1|WP_038557437.1|2010237_2010435_-|hypothetical-protein
MNKKVFSYQNNDKYFLPFLAFFSDFAVQNLPLQVFNVSILQKVCYWQAFLYPSEKIVALKAIAII
>NZ_CP007451.1|WP_038564288.1|2009319_2010168_-|aldo/keto-reductase
MPKRKLGKTNEKLSIIGFGGIMLNDNPQEFANELVAKAFDLGVNYFDVAPKYGNAEDRLGPALKPFRKNSFLACKTRRRDAAGAQKDLENSLRKLQTDYFDLYQLHELTTDDEVQTVFGTNGALETLVKAKRDGKIKHIGFSAHSVKAALFALKNFNFDSILFPINFACWNAGNFGPQVFAEAEKQGIGILALKAMALTTFREKEDLIFKNCWYKPIDDEHIMKRALRYTLSKKITAAIPPGEYTLFLKALEFMQDFSPIEEEETQELLALAKNTRPVFMHD
>NZ_CP007451.1|WP_051567716.1|2008465_2009065_-|phage-integrase-SAM-like-domain-containing-protein
MATFKFLIQGKNNPTNIYVRLSLNKGKSIKRKTGYVINPSDWSTTGYPKQTDEDLKRFKNKLEQLKATLGTKLNEATGAGAEIDGTWLEHTIDEINNKKEKTDLDRLVNYCDYFIGSLPIKVQRNGKQGVSEITIKKYKTVKNKLSAFEAKQQKTFFVKDVNKKFRTDFIKYLQEDQKTICKHLRQIPQMCKNNLFRCT
>NZ_CP007451.1|WP_051567715.1|2007747_2008380_-|hypothetical-protein
MDDIAKTPFTREALENAKDWLLIGCFIGQRVSDLLKLKSSNIQDMGGFKMIVLTQQKTGKEVAIPIHDKIKPILEKRNWSFPEPLSAVNFNLHIKDICKLAGIKEPIEGSKMICIDEEAEPKVYRKIKGVYPKWELVSSHICRRSFATNFYADTPTALLINITAHSTEKQFLEYIGKPAKDFSVQLAEYWQKEALKDKKEPHLTVMKEAN
>NZ_CP007451.1|WP_139178004.1|2006893_2007739_-|hypothetical-protein
MKVLDTKKSEEINEKYEASFYRIIDNLYDQDNKLKDFSEMKEKHDNLEPAMLKLFDSSYNDLFYWDFCPINVYEYHYNSRLGQFCNDFPGSSEVDFINIEKRTIKKRFWVRDDEDNISDKSTIVKEDTLHLVLDDFFYPFNISLFQHELALRIFLAQKKKLEFLDRKIEAISNPSINAQSEQEILINLSNSNDAMKVVYLHELGILDFLKEKMHKEMNFSVNNMAQVISAFTSIDVTTAQPYLNPIYSSGVDQKKNPLKPKNIERAWQKLSDLGFSLKKTT
>NZ_CP007451.1|WP_038557441.1|2019101_2019854_-|hypothetical-protein
MNFIVNIPLTRLRHNDYFQYMTDVKGLVTQATPAALNVEEEAVAFDNSFTALDEAINVDKGSVFTEKIQDADHRRDNTWSALNGRVKATLYSPIPEEVEAAKHLERVFNLYGNIRNLSLKEQTAAATNLNNDLKKPKMAVHCQTIGITPWVLAHEAENTAVNDLQNQRDSEKANRNYTKAKEVRVAFDEEYNALVNRINAMVTLRMATPVIENFIIEVNQKIKNLENQLAVRQGHRDSGEEEPSDSPVDE
>NZ_CP007451.1|WP_038557442.1|2020827_2021124_+|TM2-domain-containing-protein
MNKSYLQSKIKSTGTAYLFWFFLGAHYAYLGKWGLQFLYWFTLGGLGIWALIDLFIMSSKVSKINAPIFEEIEKMEKREKDEDHARQMAMMAAVAGNK
>NZ_CP007451.1|WP_038557443.1|2021471_2021915_+|hypothetical-protein
MNQIINFILLGFIGPQEIIILLIIPALSVIPLIFYLLTLQNTFNAISIENRRMQSGEVWLTLIPLFGLVWQFIIVNRLADSLKAEFNAKNITVDEERPGVGIGLAYCILFCCSIIPFVNFLTGVAGIICWIIYWSKINNYKIKLIQS
>NZ_CP007451.1|WP_038557444.1|2022273_2023161_-|Mph(E)/Mph(G)-family-macrolide-2'-phosphotransferase
MKNTDIQKLAERHGLMLSDKMKFNEMGIDFKVGFATDKDENQWLLRIPRRPDLGKQIAKEKLILQLVCKHLTAQVPDWKIANEELVAYPLLDGKPALTYDAETYEVSWNMDKDSPNYIQSLAKILVQLHAIPKEEVVLNGLEVTTPESLRSEISERLRLVKSELGISNDLENRYKKWLDNDTLWPNFTKFIHGDLYAGHILTYADGNVCGIIDWSTARISDISQDFSGHLTVFGEESLKSLISEYEKQGGKIWNMIFEQAVERAAAAPLAYGYFAVETQDEVHINGAKVQLGVQR
>NZ_CP007451.1|WP_038557445.1|2023166_2024390_-|MFS-transporter
MENQKWFNTYIFIWAGQFVSMLTSYAVQFAIVIWLSLEYQSAEVLAYAGIAGILPQAIIGPLAGVYIDRTNRKRIMILSDTFIAVCAIVLIFILNKETVNLVWIYIMLGLRSVGNAFHSPALQALAPLIVPKKELLRVAGINQMLHSICSIGGPALGTVAIAILPISNVLYLDLIGALLAISSLMMVRIPQTIKGSKFSVHTISTEFIDGLHIVSKNRGLSYLFLYAMAITFVIMPAAIMFPLLTTGHYGGGKWEMGLVEIVWGGGMLIGGAVLGLFKVGMSKIVLVNSMYIILGLTFLLSGVFPKEWFIGFVLVTAIGGIGLSVFYACFTAIVQITVKPEMLGRVFSLYYSLAVLPSIIGLLFTGVIAENIGINITFIISGCLAIVIGLLSYGSEKLMQLGNNLKK
>NZ_CP007451.1|WP_038557446.1|2024875_2025646_+|aminoglycoside-6-adenylyltransferase
MIQLQMIDKTKSIAQNDKNISAVFMYGSFTKNEGDKYSDIEFYIFLKDKEKFSAENWVSQIHPLALYFTNEYGSEVAIFENMIRGEFHFLTNDQMEVIKSWDGLVEFSDFDKMILVDKEVLLTNTLKEIKTKVPDRTTNENILWLSQSLLNVLLTTSNLIKRQEFAHAYQSLSNVQKYLLWLIRIETYQTKHWESPTKGLEKDIDPDWYSLFQQTTSELDPTDIKTAFKKTLTLTEKLFDNLGVEAKLKGVLRRIE
>NZ_CP007451.1|WP_038557447.1|2026140_2027361_+|tetracycline-resistance-MFS-efflux-pump
MKSNKNSTLIFIIVVVVIDTAGFGLIFPVLPQLLTNLLHSDISTAAEYGGWLSFAYAAMQFVFAPILGNLSDQYGRRPVLLSSLFGFSIDCVFLAFAPNILWFFVGRTIAGITGASYSVASACVADISTDENRTKNFGIVNAAFGLGFIIGPVIGGTLGQFGTHTPFIVAAILSFINFTFGYFFFPESLNIGTRRIFDWKRANPFGSLKYLSEFPLINTLVLSMIFVSIANHSMESVWAYFTIEKFKWNTSLIGYSLAVIGLLSIVVQLWLVGILVKKLGDRRMALLGLILTMTGFFLFAFTEWQWLLLGALLIYIIGGVQGTAIQSITSSIIPDNEQGELQGSLGSLMGLTTLIAPLLMTSSFSYFTGKNSAIYFPGISFLIAALLTLISLILLIKSFKKHKMKK
>NZ_CP007451.1|WP_038557448.1|2027523_2028033_+|hypothetical-protein
MIKKNVMRVIMLIIAVNLISCDSIKKATEPEDIGMYAFELLKTLSQTTKSDYVNSFLTIEEIRVLGKNEVVVTDSDTRNELTSMPKEEWVEDIEDDYNELKQDGGENGIKWAEIEYLDFVYEMDNEGGIKVCEGELFFKYKEDSYSVDLAAIFDGTEYKLVELDYLEMQ
>NZ_CP007451.1|WP_051567719.1|2028228_2032956_+|PAS-domain-S-box-protein
MSKPGDSSRLNELAELRRQNAELKAIVEKMVAEQKQPVKNLLQCEQKYSLLFEKSAIPTSLSRLPEGVFVDVNEAFEHEFGITKQDALGKTALELGVIPDKDGHRQILEALKESGSVRHQEMVLNFKSGENRYYEININKVDINGEEYLLTTIQNISKYKNAKRKLKESYDLIRIAEEKAKLGGWSVRLKENRIYWSDEVAAILEVPAGYSPLFEDAIKFYAPEWRDKFTEVFNRCAIEGIPYDEEMEVITSTGKRVWIRTIAEAIKNKNGKIVKIQGAFQDITLKKQAEKKLKDSEAKYKAIFESSGTATLIVDSDMAILMANTECLNATGYAPAELIGRKWTDYVAPESLEEMLKKHELRRKNPELVSPKYEVKLLNKTGEKRDVVLKINMIQGTSQSVVSMLDITERKRAEAAFEEYFDNDISSDYVALVSGEIVSCNKTFRDLFGFEKKSDAENFNITNLYKEPADRKQIIHLLTQNRKLENYEVEFVSKDGKTIFALVNAIGIFDKNNKLEKIRGYIVDISEQKRVEKEILKLSRAVEQSPASVIITDLEGNIEYANPKALAVTGYSKEEMIGQNPRILNSGEKQKSKYKQLWETISSGKEWFGEFHSKKQNGELYWESASISPIFNEKQEIINYVAVKEDITERKKIIDDLKAAKEKAEENEKKFLVAFHSSPDISMITNVDTSEILEANDAFERVTGFSKAEIIGNTTADLKLWVNKADREKYFEILLRDKRVIGFESLFRKKSGETFVGLVSGQMIQIQNQNYLLGNIYDITDRKKAETELLKALEKVEESEEKFKNLYESLSISYLILKDGVCIECNEATLPIYGIDSKDEIIGKIPPDFAPEFQPNHKKSSEEAKRHIQAAIEKGEHTFEWITKRINGQEFYSEVSLKSFYHKNELYMQSLVADISERKKNEAELIAAKELSAENELFLSTLINTLPDLVWLKDINGAYLMCNKRFEEFIDLPEHKIIGKTDYDLMEADLADFFSKKDKEAVAAGKSLLNEEHKIFENNKYSAYVETIKTPFYRNGELVGVLGIGRNITERKNAELELRKAKEKVEESESKFKNLYESLSIAYLILEDGVCIECNKAALEIYGVESKDEIIGKSPTEFSPEFQPNNVPSADEAIKQTQIALEKGFHTFEWQAMRKNKELFYNQVSLKKFYYKNKMQMQCLTSDITERKRIENELIAAKEKAEESDRLKSAFLANMSHEIRTPMNGILGFTDLLLDPDLKSEEKEYYINIVHKSGQRMLNTVNDIIEISRIEAGLVEQRNELTDFNNRVEDLVLFFTPEATGKGQKIILEKLLPAEKKNIVTDQIKLDSILTNLIKNAIKYTPHGTITIGCQMKGQMIEFYIKDTGIGIPKHRHEAIFNRFEQADIKDTRVFEGSGLGLAISKSYVEMLGGKIWVESEEGKGSIFYFTLPVTDNAPEKSINDDEISPDNKNAESKTKKLKIIIAEDDAASRKYLTLLTNKFGSEILEAETGNRAIEICRSHSDIDLILMDIQMPGMDGYEATRQIREFNSDVIIIAQTAYALGGDREKSIAAGCNDYISKPIDRTKLENLLQKYFG
>NZ_CP007451.1|WP_038557449.1|2033214_2033658_+|IS200/IS605-family-transposase
MSNFKKLSHVIYRCTYHIVWTPKYRYRILEGLVKEQLLRDIPMLLEWKSCELIEMNIQKDHIHIIVSMPPKMSLSQLMGILKGKTAIKIFKSYPQLKTKPYWGNHFWSRGYCADTIGLDEEKIKKYVKYQEEQERLEEQQRLNFGPL

Crispr_ID: NZ_CP007451_5

• CRISPR_ID: NZ_CP007451_5
• CRISPR_location: 2216528-2216608
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP007451_5

Consensus_repeat	Method
AATGTTCGATCCCGAACTGGCTTT	CRISPRCasFinder

spacers of NZ_CP007451_5

>5.1|2216552|33|NZ_CP007451|CRISPRCasFinder
GGCGTTTATTGAACTGGCATTTCCTTCGAGAAA

CRISPR arrays and Neighbor proteins around NZ_CP007451_5

CRISPR arrays

The CRISPR arrays of NZ_CP007451_5

>merge|NZ_CP007451|5|2216528-2216608|CRISPRCasFinder
AATGTTCGATCCCGAACTGGCTTTGGCGTTTATTGAACTGGCATTTCCTTCGAGAAAAATATTCGATCCCGAACTGGCTTT

>NZ_CP007451|5|3|2216528-2216608|CRISPRCasFinder
AATGTTCGATCCCGAACTGGCTTT	GGCGTTTATTGAACTGGCATTTCCTTCGAGAAA
AATATTCGATCCCGAACTGGCTTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007451.1|WP_038557643.1|2206470_2207409_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP007451.1|WP_038557675.1|2222313_2223720_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP007451.1|WP_051567735.1|2225138_2225429_-|CD225/dispanin-family-protein	unknown	unknown	gnl|CDD|377375
NZ_CP007451.1|WP_074780126.1|2213488_2213761_-|DUF4834-family-protein	unknown	unknown	gnl|CDD|374375
NZ_CP007451.1|WP_051567733.1|2220807_2221761_+|mechanosensitive-ion-channel	unknown	unknown	gnl|CDD|366370
NZ_CP007451.1|WP_038557639.1|2205105_2206416_+|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl|CDD|223749
NZ_CP007451.1|WP_038557663.1|2215456_2216170_-|DUF2807-domain-containing-protein	unknown	unknown	gnl|CDD|371327
NZ_CP007451.1|WP_038557669.1|2219947_2220793_+|mechanosensitive-ion-channel	unknown	unknown	gnl|CDD|225803
NZ_CP007451.1|WP_051568159.1|2218105_2219773_+|PDZ-domain-containing-protein	unknown	unknown	gnl|CDD|223864
NZ_CP007451.1|WP_051567734.1|2224730_2225132_-|DUF2752-domain-containing-protein	unknown	unknown	gnl|CDD|378499
NZ_CP007451.1|WP_038557654.1|2209847_2211239_-|putative-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|225420
NZ_CP007451.1|WP_038557684.1|2228698_2229058_+|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl|CDD|367747
NZ_CP007451.1|WP_038557647.1|2207411_2208704_-|glycosyltransferase-family-4-protein	unknown	unknown	gnl|CDD|340825
NZ_CP007451.1|WP_038557678.1|2223741_2224674_+|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl|CDD|224007
NZ_CP007451.1|WP_038557672.1|2221767_2222196_+|nucleoside-2-deoxyribosyltransferase	unknown	unknown	gnl|CDD|377443
NZ_CP007451.1|WP_038557633.1|2204542_2205109_+|N-acetyltransferase	unknown	unknown	gnl|CDD|100048
NZ_CP007451.1|WP_038557681.1|2225917_2228398_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|379720
NZ_CP007451.1|WP_038557651.1|2208706_2209855_-|glycosyltransferase	unknown	unknown	gnl|CDD|340849
NZ_CP007451.1|WP_038557657.1|2211381_2212917_-|glycine--tRNA-ligase	unknown	unknown	gnl|CDD|235240
NZ_CP007451.1|WP_038557660.1|2213769_2215140_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP007451.1|WP_038557643.1|2206470_2207409_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.39538e-34
NZ_CP007451.1|WP_038557675.1|2222313_2223720_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.61332e-30
NZ_CP007451.1|WP_051567735.1|2225138_2225429_-|CD225/dispanin-family-protein	gnl|CDD|377375	pfam04505, CD225, Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.	1.59383e-21
NZ_CP007451.1|WP_074780126.1|2213488_2213761_-|DUF4834-family-protein	gnl|CDD|374375	pfam16118, DUF4834, Domain of unknown function (DUF4834). This family consists of uncharacterized proteins around 90 residues in length and is mainly found in various Parabacteroides and Bacteroides species. Protein in this family are characterized by a strongly conserved KDEGEYVD motif on the C-terminal and a very divergent N-terminal. The function of this family is unknown.	1.95039e-07
NZ_CP007451.1|WP_051567733.1|2220807_2221761_+|mechanosensitive-ion-channel	gnl|CDD|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	1.23918e-20
NZ_CP007451.1|WP_038557639.1|2205105_2206416_+|nucleotide-sugar-dehydrogenase	gnl|CDD|223749	COG0677, WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_CP007451.1|WP_038557663.1|2215456_2216170_-|DUF2807-domain-containing-protein	gnl|CDD|371327	pfam10988, DUF2807, Putative auto-transporter adhesin, head GIN domain. This bacterial family of proteins shows structural similarity to other pectin lyase families. Although structures from this family align with acetyl-transferases, there is no conservation of catalytic residues found. It is likely that the function is one of cell-adhesion. In Structure 3jx8, it is interesting to note that the sequence of contains several well defined sequence repeats, centred around GSG motifs defining the tight beta turn between the two sheets of the super-helix; there are 8 such repeats in the C-terminal half of the protein, which could be grouped into 4 repeats of two. It seems likely that this family belongs to the superfamily of trimeric auto-transporter adhesins (TAAs), which are important virulence factors in Gram-negative pathogens. In the case of Parabacteroides distasonis, which is a component of the normal distal human gut microbiota, TAA-like complexes probably modulate adherence to the host (information derived from TOPSAN).	2.5465e-44
NZ_CP007451.1|WP_038557669.1|2219947_2220793_+|mechanosensitive-ion-channel	gnl|CDD|225803	COG3264, COG3264, Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane].	6.83839e-59
NZ_CP007451.1|WP_051568159.1|2218105_2219773_+|PDZ-domain-containing-protein	gnl|CDD|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	7.78844e-98
NZ_CP007451.1|WP_051567734.1|2224730_2225132_-|DUF2752-domain-containing-protein	gnl|CDD|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	1.31503e-13
NZ_CP007451.1|WP_038557654.1|2209847_2211239_-|putative-DNA-binding-domain-containing-protein	gnl|CDD|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	1.57564e-80
NZ_CP007451.1|WP_038557684.1|2228698_2229058_+|BlaI/MecI/CopY-family-transcriptional-regulator	gnl|CDD|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	6.40525e-35
NZ_CP007451.1|WP_038557647.1|2207411_2208704_-|glycosyltransferase-family-4-protein	gnl|CDD|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	3.14853e-44
NZ_CP007451.1|WP_038557678.1|2223741_2224674_+|sugar-phosphate-isomerase/epimerase	gnl|CDD|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	4.27963e-24
NZ_CP007451.1|WP_038557672.1|2221767_2222196_+|nucleoside-2-deoxyribosyltransferase	gnl|CDD|377443	pfam05014, Nuc_deoxyrib_tr, Nucleoside 2-deoxyribosyltransferase. Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyzes the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides.	1.03319e-16
NZ_CP007451.1|WP_038557633.1|2204542_2205109_+|N-acetyltransferase	gnl|CDD|100048	cd03358, LbH_WxcM_N_like, WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization and transacetylation reactions of keto-hexoses. It contains an N-terminal LbH domain responsible for the transacetylation function and a C-terminal isomerase domain. The LbH domain contains imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), typical of enzymes with acyltransferase activity.	1.01192e-61
NZ_CP007451.1|WP_038557681.1|2225917_2228398_+|TonB-dependent-receptor	gnl|CDD|379720	pfam14905, OMP_b-brl_3, Outer membrane protein beta-barrel family. This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.	9.62608e-102
NZ_CP007451.1|WP_038557651.1|2208706_2209855_-|glycosyltransferase	gnl|CDD|340849	cd03822, GT4_mannosyltransferase-like, mannosyltransferases of glycosyltransferase family 4 and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.	1.70614e-41
NZ_CP007451.1|WP_038557657.1|2211381_2212917_-|glycine--tRNA-ligase	gnl|CDD|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0

Protein sequences

>NZ_CP007451.1|WP_038557663.1|2215456_2216170_-|DUF2807-domain-containing-protein
MKTFSKFLFLVMIAVTSYGTVLAGNRDETQTRQISGFNAIKVSTGIDLYLTMGNAEEVKVVADDDLINDLITEVEGGTLKIYMKRRNWFNWSSGNETRKVYVTVKELKELSASSGSDVGSTNTLEGESLEVSCSSGSDLEIEVFYKNLSVDTSSGSDARLHGKVKTLRVDASSGSDIKAGSLESVICHANASSGSDITVSVSDELYANASSGSDINYHGNPAIRDIDESSGGDVSQR
>NZ_CP007451.1|WP_038557660.1|2213769_2215140_-|hypothetical-protein
MKNLAVKIGFVLILLTALCKIPATAQSGNPLQFLSEVSQSSQSNPAFHNKTEKLVIGLPVLSGAALHWNANFSADYFFTENFDYSFDNFYTSLGKPGDAVAYATLPLVYLSHRNDKRTLSFSLSERALGWGNFDHEFLKFIDQGLLPYYGQEEEFGPFSFKTQVFRELAFSYAKQVNRKLSVGIRPKVLFGRAFYDIQNLNVIVHTDEDRKVLQVIPEGSYRISGPIDVQYDPLKGKTSIKTDFTAGDYFFKFKNMGAGIDLGFTYQLNKETTVAAAITDIAFTTLNYKAYKNTFVGSIDYTHLYQSSDSAAAYYFEPRAALDALTDSLPYKTTSEAFAQRRYELLPVTLNLMVTHRINDGMTLNFANNFTYYNGDANNYLAGYFNLLLGTRFELSSGLNLYNIKQVMPGFACSYTARGVQLYLATNNIARLVQPSKAKNLNLSFGVNLLFSTEPN
>NZ_CP007451.1|WP_074780126.1|2213488_2213761_-|DUF4834-family-protein
MTLFITLYIVGFLRTLVIIAVIYFGFRFIVRYLFPKIIDKGMKNMQQKMQEQQRQQHPKRPEGEVTVENRRSSNRNNQDNGEYVDFEEVD
>NZ_CP007451.1|WP_038557657.1|2211381_2212917_-|glycine--tRNA-ligase
MAQEDIFKKLVAHCKEYGYVFQSSEIYDGLGAVYDYGQMGVELKNNIKKYWWDSMVLLHENVVGLDSAIFMHPTIWKASGHVDAFNDPLIDNKDSKKRYRADVLIEDQLAKYEEKMNKEVAKAAKRFGDAFDEKQFRETNPRVLANQEKWNTLHTRFSDALNDNNLAGLKQIIEDEGIVCPISGSRNWTDVRQFNLMFATEMGSTAEGASKIFLRPETAQGIFVNYLNVQKTGRMKIPFGIAQIGKAFRNEIVARQFIFRMREFEQMEMQFFVRPGSELDWFEKWKETRMKWHRALGFGDENYRFHEHEKLAHYANAAVDVEYKFPFGFKEVEGIHSRTDFDLSQHEEYSGKKIRYYDPELGESYVPYVVETSIGVDRMFLQVISASYCEEQLEKDTRVVLKLPPVLAPVKLAVMPLVKKDGLPEKAREIIDELKFDFNCQYDEKDSIGKRYRRQDAIGTPFCVTVDHQSAEDNTVTIRYRDTMEQERVAIADLGKIIGEQVSYKTLFGKL
>NZ_CP007451.1|WP_038557654.1|2209847_2211239_-|putative-DNA-binding-domain-containing-protein
MTNDDLKNIIFQGESNTVEYKQSFNKAVIETIVAFSNTDGGKILIGVNNKGIPTGISITEETIQKWLNEIKQTTEPAIIPDTKIIKYNNKTIVVFSVNEFPIKPVSCKGRHYIRKMNSNHILSADEITELRLTSLNYSFDSFEVDTDFEELDKDAIEVFRNKSGNSGRFQLSGNIKHDFARLGLIKNNRLTRASELLFGNHLTNIHLGRFKSETTIIDDLMIRSPLVLAVEEALTFIKKNIRLGFKFGGTGLQRTEHWQYPIPAIRELLLNAIVHRDYSTPTDVIVKIFDESIEITNPGKLMEGLKIEDLYTDNYISRHRNKLLTEAFYLTGDIEKYGTGYKRLREWFSDYPDLQFSVSDLSGYIQAKITLSLANKKNEPANEPVNEPVNEPVNEPVNERQKQIINRIKIDPSITIAKLAIACSAGRETIKRDLKLLRELNIIQRVGSAKTGYWEIVKPKQND
>NZ_CP007451.1|WP_038557651.1|2208706_2209855_-|glycosyltransferase
MTKEKRKIAIVGSAYPLRGGGIATFNERMAKAFIDNGDEVKIYTFSLQYPSILFPGKTQYSEETPPEGLDIEVMVNSINPFNWIKVGRYLKKLAPDLVILRYWIPFMGPCLGTISKIVRKNKKTKVIAITDNVIPHEKKPGDSLLSKYFVKNVDAFITMSKSVLNDLNQFDTTKPRSYTPHPLYDNFGEIIPKATAKEQLGLDAKTNYILFFGFIRDYKGLDILLEAFADNKLRELPAKLLIAGEFYSKPDKYLEIIKKNKLQDYIELRTDFIPNTDVHKYFCASDVVVQPYKTATQSGITQVAYHFNKPMITTNVGGLAELIPNEKVGYVVNSDKQEIADAIYRFYELKKESEFSTNAAEEKKKYSWEVFVEKLIQIYQSL
>NZ_CP007451.1|WP_038557647.1|2207411_2208704_-|glycosyltransferase-family-4-protein
MKKILIITYYWPPSGGGGVMRWLKMSKYLPEQGWQPIIYTPENPDASVNDESLLQEIHPNTTVLKYPIWEPYDIYRFLTGKKKDTKFKAGYVSEASSGNWKSKLSVFIRGNFLIPDPRMFWIRPSIKYLSKYLNENDIDAIVSTGPPHSMHLIALGLKKRFPDIKWIADFRDPWTDIDFYSKLRLTKWADKKHRKLEKKVLTKADSVITVSPGCARDISKIANRKIEIVNNGYDPADFEFAEDKLDKEFTISHFGAFNKDRNPVHLWSILQKLAEEDNSFKANLKIQLIGQTDNTILESIRNCNLYDNVCIIEHLPHKKGLSLLKSSQVLLLPLNNAPNVMGILPGKMYEYLALKRPILAIGPTIADYAKIISETQSGSCHNFNDKTGMEKTIRDYYELFKKNALRVNSNSFQEYSRKNLAKKIIDIATK
>NZ_CP007451.1|WP_038557643.1|2206470_2207409_+|Gfo/Idh/MocA-family-oxidoreductase
MSKRFALIGAAGYIADRHMRAIKETGNDLICATDRFDVMGRIDSYFPEAEFFLEHENFEKYMDDLRMAGNPVDYVSICTPNYMHASHIRFALRNGADVICEKPLVIYPRELDVLKEIEKETGKRVNTVLQLRYHQTILDLKKKVDAGGDKMYDVDLTYMTTRGKWYFKSWKGEMEKSGGVATNIGIHFFDMLTWIFGAVKENVIHVYEADKAAGYLQLEKARVRWFLSLDARDLPAYATERGMRTFRSITVNGDEVEFSGGFTDLHTVTYQNILNGNGFGLDDARESIVLTDYARNTKPVGLKGDYHPLLKG
>NZ_CP007451.1|WP_038557639.1|2205105_2206416_+|nucleotide-sugar-dehydrogenase
MTYKKQILDKVAEKQLLIGVVGLGYVGLPLAVSFAQEGNKVLGFDKAEAKVKKVNAGENFIGDIEDWELEQVAESNYLKATSDFSELKNCDAILICVPTPLDRYKKPDMSYIEAACTEIGRNMKEGTFVSLESTTYPTTTEDFMLPIIERESGLKQGEDFWLAFSPERVDPGNQDFKTKNTPKVLGALTSDGLEIGEAIYKLAIENVHLVSSPRVAEMVKILENTYRLINISLINELALLAGKMDINIWEVIDAAKTKPFGFQAFYPGPGVGGHCIPLDPFYLEHIAKKFNFELSMIHTAGHIDLLMAHRMTLKITSALNRQKKALNGSKVLFLGVAYKPNIDDERESPALKIIDEVVNKGAEVSYHDPYIPEIKTEGDRIFTSTNLSEEILNDADCVVITTHHSVFDAEFIELNSKLVVDLRNVIKEASDKVYKL
>NZ_CP007451.1|WP_038557633.1|2204542_2205109_+|N-acetyltransferase
MERYYAHETAIIDEGARIGEGSKIWHFCHVMGSAEMGKDCILGQNVFVGNKVKLGSNVKVQNNVSLYEGVICEDDVFCGPSMVFTNVINPRSAVERKTEFKPTLVRKGASIGANATIVCGTTLGEYCFIGAGAVITKDVKPFALMVGVPAVQKGWVSRSGAILGADLVCPETGEKYKLAGDNLELVSE
>NZ_CP007451.1|WP_051568159.1|2218105_2219773_+|PDZ-domain-containing-protein
MKKRLLIGITIVAVIGISFFSFTRDEKNFEIAKNLDIYHTLFRELNMFYVDEVNPNDLVKTSIDEMLSSLDPYTNYISEDQMEDFRFMTTGEYAGIGALISKQNDNIIIAEPYEGFPAQKFGIKAGDIILEVSGKDTKDMNTEDVSTLLKGPANKPVTIKLQRPGQKKPFTVDVVRQKISIDAVPYYGMIDQNTAYIRLSNFTTNCSEDVKKAFLELKENNPDGLILDLRGNPGGLLVEAVKIVNLFVPKGEEIVSTRGKVKQWDKVYKATAEPLDTTMKIAVLVNSGSASASEIVSGAIQDLDRGIIVGTRTFGKGLVQTTRDLSYNTKLKVTTAKYYIPSGRCIQALDYSHRNEDGSVGHVPDSLISEFTTKKGRKVYDGGGVVPDVKIEGDKLSSLSIELVTRFLIFDFATKYSNENESIPEPEEFSITDDIYRQFADFVEQSGFNYESASQDDLKELLETAKYEKYYELAKEEFDALAAKIEPDLDKDLAAFRPEISDLLESEIVSRFYYQKGSIRASINDDKGIAKTIEALHSETAYAAYFKPGLVVGMN
>NZ_CP007451.1|WP_038557669.1|2219947_2220793_+|mechanosensitive-ion-channel
MTFKEILNTELYSKGDFTITVYNIFLILIVVLITLIALKIVRRFFKRFINKQEAERRSYWSIYLILRYIVWVIIIVFLLESSGFRVSVLLASITALLVGVGFGIQQLFSDIASGIVLLVERNLQINDVIQLQDGTVGRVIHIGLRTSRLKTRDDIIQVVPNSNFVNDKIINWSHMDYNTRFSVDVGVAYGSDTRLVTQILLDCAAKNNNVSHSPKPFVRFNNFGDSALEFQVFFWVRESFYVENTKSELRYAIDDEFRKNGVQIPFPQHDIHIKSTVEQPK
>NZ_CP007451.1|WP_051567733.1|2220807_2221761_+|mechanosensitive-ion-channel
MKKIIKFIIPFLLLLIAVYFLVFVEKRELVSPDYYNFFKKAGSILLIVSIAWSLMAILRAFKKVILSKFDTSKEDNLRQRKFLTQFNIMESIIYFLIVLIAIGASLMLFEEVRQLGISLFASAGVAGIIIGFAAQKLIATVLAGLQIAITQPIRIDDVVVIENEWGRIEEITLTYVVVKIWDQRRLVVPSTYFFEKPFQNWTRTSAEILGTVFLYTDYHVSFDALRKELTRLLESTPLWDKRVNVLQVTDAKEYGVEIRALVSAKDSPTAWDLRVFIREKMIEFIQKNYPESLPRTRVVFEQGEQKSTTDLLNKTKA
>NZ_CP007451.1|WP_038557672.1|2221767_2222196_+|nucleoside-2-deoxyribosyltransferase
MKIYFAGSIRGGRQDAALYEQIIQYLKSFGEVLTEHVGDPALTSAGDDGPNDQFIHDRDLKWLQSSDVIVAEVTAVSMGVGYEIGRAVEMGKPVLCLFREGPKHNLSAMIAGSKDVVLIHYSDIEELKKPLQGNLFSFKASK
>NZ_CP007451.1|WP_038557675.1|2222313_2223720_+|Gfo/Idh/MocA-family-oxidoreductase
MDSKKSNQLDRRKFLGLSALGLSSLTILPSWTINGVKIAPSDRVTMGFIGLGQQGMNDFRSFSAVPGVEVVAGCDVDSMKTERFKRTVEEWQKGLGLSPRVDKYEQYEELLERKDIDAVEVCTPDHWHALMTIHACQAGKDVYVQKPLSFTIAEAEKMVRVANDTKRIVQVGSQQRSSAEFQKAIALVQSGAIGHIDKVYAKVGDPPAPLDLPEMKVPGNLNFNLWMGPLNDPKIHYHPDLCPPISLDPAEREKLWGAWRWYRETGNGFTADWGAHMFDIAQAAIGMDGSGPAEIIPKGVDGADYLTFKYLNGVVMTEQPYLEDMPAAQGIKFIGDDGWIEVARGYLACSKSELVPDELRGNRPRNLTPEERRKMFEEMQKAQAKGGGSFEISSPHMEDFISCVRSRQKPIAPVEVGASTAITCCLGNMATELQRSVKWNPATHSFGTDKEAWNHRLYDYEYRGSYKL
>NZ_CP007451.1|WP_038557678.1|2223741_2224674_+|sugar-phosphate-isomerase/epimerase
MDKREFLKKMGLLTAGGMVAGSIKPASAAAMVGRGKKEIGLQIYSVMRELNADVPNGLKKIKDIGYSTIELAGYGNRKMGEYSVEEYRKLADDAGLKITGSHVNPPTRDITKDKLGELADFWKKTVEDHVKFGVKTLVQPMMPNVPTHDAVKVVCESFNQAGEIAKSAGIKFGYHNHHMEFGRIVKPEDKDKQRNPWMPVGDVIYDLFLNGTDPDLVFFEMDVYWTVMGANDPLEYFEKYAGRFPVLHIKDRSVLGQSGMMNFKNIFNKAYENGLEGFYVELEGIRDGSMTQFEGVEKCFDFLNEASFVK
>NZ_CP007451.1|WP_051567734.1|2224730_2225132_-|DUF2752-domain-containing-protein
MKQTINSILLLVIIGVAVLFFVVDPAQHEIFPQCLFHSLTGGYCPGCGSQRALHSLLHFDFAGVVGYNFLFLPAALFILYHYLYPLLNKAFGWKLPNLFYKKQTPLIVLAIVIVFWIARNLPWYPFNVLAPVG
>NZ_CP007451.1|WP_051567735.1|2225138_2225429_-|CD225/dispanin-family-protein
MNEQINKPQVPPPNYLVFAILATLFCGKIFGIVAIVFAAQVNSHWNAGNYEAAKSASRNAKIWAWVSFAAGLAWIILFAMLSVFGVLAGIMQGAFN
>NZ_CP007451.1|WP_038557681.1|2225917_2228398_+|TonB-dependent-receptor
MKYLKNVILIALLFIGVNSYALLKNPVIENDPNDDGKGKIVGTIVEKDTETPMEFANIAVYKEADSTLVTGGITNEKGVFEITNLDYGNYYLVANFIGFDEGNVVDIKLDRTNRVHDLGEINLAPSTVAIGEVNVVADKAAVEYKLDKKVVNVSQVISAIGGTAVDVLENTPSVQVDIEGNVSLRGSGNFTVLIDGRPSVLSGSDALRQIPSSAIENIEIITNPSAKYEPDGAAGIINLVMKKNSMNGLNGIVNASVGTGDKYLVDLMLNYRFEKLNLFFGADWRDEINHGKMASERETYYSDTTEYLNMAGDRKWIRGGHRFKGGADFFLGTNTTLTLSGETGTSERGNEGGGRTENFTIPASEQILSISEETSERNNDFYTLNMNFQHKFDDKGHRIEATAFYSDETGTDNEIEGELLADGNFNPTNEYLSNVSTFETEDEQDIRLKLDYTYPFSEDGRFEAGYQGRLESEMETLEFRDYDQATDTWIINENYSSATDFQRDIHAAYSTYSNKVGKLAYMAGLRGELTIREIKNTSAENVSSLNRFDLFPTAHFSYPLAQTADVTASYSRRINRPGGRDLDPTPNYYNRYTIRYGNPDLEPEYTNSYELGFMKRFGETRSFVSVDVFRRVTNNKIDRTQELGEDGIFYLYTDNFDKDYSTGLEVTGNLSYKKWLTVNASVNVYDYKITGELNGESIDRQSTNWGGRMNTTFKFAENSRLQVNAFYRGKSVSAQGESGAMFFTNVSYRQEFMNKKLSATVSVRDPLGTGRFERTSYGDDFNSWFRFEREPRVVMLTLSYKINNFKEERRGEGGGDGGMDMGGGEF
>NZ_CP007451.1|WP_038557684.1|2228698_2229058_+|BlaI/MecI/CopY-family-transcriptional-regulator
MKKLTKKEEELMKILWKLEKAFVKDIVELYPDPKPHYNTISSLVRLLQDKGVIGFKQYGNTYQYFPLISKEEYRRSFMNQVVSDYFDNSYKSAVAFFVKEKNLSDEEIDELVKLIKNKK

Crispr_ID: NZ_CP007451_6

• CRISPR_ID: NZ_CP007451_6
• CRISPR_location: 2905401-2905501
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP007451_6

Consensus_repeat	Method
TCCCGATGTTTCAATCGGGACAGG	CRISPRCasFinder

spacers of NZ_CP007451_6

>6.1|2905425|53|NZ_CP007451|CRISPRCasFinder
CACTTCGCCAAAGGGGGACTAAACAGCCGCGTCCTCTTCTGTAAAAGGAGGTG

CRISPR arrays and Neighbor proteins around NZ_CP007451_6

CRISPR arrays

The CRISPR arrays of NZ_CP007451_6

>merge|NZ_CP007451|6|2905401-2905501|CRISPRCasFinder
TCCCGATGTTTCAATCGGGACAGGCACTTCGCCAAAGGGGGACTAAACAGCCGCGTCCTCTTCTGTAAAAGGAGGTGTCCCGATGTTTCAATCGGGACGGA

>NZ_CP007451|6|4|2905401-2905501|CRISPRCasFinder
TCCCGATGTTTCAATCGGGACAGG	CACTTCGCCAAAGGGGGACTAAACAGCCGCGTCCTCTTCTGTAAAAGGAGGTG
TCCCGATGTTTCAATCGGGACGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007451.1|WP_038558672.1|2897379_2898447_+|3-phosphoserine/phosphohydroxythreonine-transaminase	unknown	unknown	gnl|CDD|235428
NZ_CP007451.1|WP_038564704.1|2907605_2909093_+|altronate-dehydratase	unknown	unknown	gnl|CDD|377287
NZ_CP007451.1|WP_168136466.1|2915170_2916451_-|TldD/PmbA-family-protein	unknown	unknown	gnl|CDD|223389
NZ_CP007451.1|WP_051567844.1|2906024_2907524_+|tagaturonate-reductase	unknown	unknown	gnl|CDD|235147
NZ_CP007451.1|WP_157470801.1|2887793_2888558_+|IS5-family-transposase	unknown	unknown	gnl|CDD|379129
NZ_CP007451.1|WP_038558694.1|2911304_2913632_+|sodium-translocating-pyrophosphatase	unknown	unknown	gnl|CDD|376979
NZ_CP007451.1|WP_038558669.1|2895681_2896767_+|glycine-cleavage-system-aminomethyltransferase-GcvT	unknown	unknown	gnl|CDD|234742
NZ_CP007451.1|WP_038558712.1|2919616_2920741_+|histidinol-phosphate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|223157
NZ_CP007451.1|WP_051567842.1|2895155_2895500_-|Hpt-domain-containing-protein	unknown	unknown	gnl|CDD|366732
NZ_CP007451.1|WP_038558680.1|2899632_2900883_+|DUF1015-domain-containing-protein	unknown	unknown	gnl|CDD|377633
NZ_CP007451.1|WP_038558715.1|2921043_2921901_-|HAD-IIA-family-hydrolase	unknown	unknown	gnl|CDD|319827
NZ_CP007451.1|WP_038558664.1|2892519_2895108_+|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl|CDD|274529
NZ_CP007451.1|WP_038558657.1|2888992_2891695_-|pyruvate,-phosphate-dikinase	unknown	unknown	gnl|CDD|236446
NZ_CP007451.1|WP_038558690.1|2909309_2910977_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|378963
NZ_CP007451.1|WP_038558709.1|2918498_2919515_+|glutamine-synthetase-beta-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|177922
NZ_CP007451.1|WP_038558685.1|2904393_2905044_-|DUF4878-domain-containing-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_051567843.1|2901278_2904254_+|pyruvate,-phosphate-dikinase	unknown	unknown	gnl|CDD|376527
NZ_CP007451.1|WP_038558703.1|2914084_2915098_+|dihydroorotate-dehydrogenase-like-protein	unknown	unknown	gnl|CDD|236051
NZ_CP007451.1|WP_038564706.1|2916567_2918094_-|TldD/PmbA-family-protein	unknown	unknown	gnl|CDD|223389
NZ_CP007451.1|WP_038558676.1|2898517_2899438_+|3-phosphoglycerate-dehydrogenase	unknown	unknown	gnl|CDD|240651

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP007451.1|WP_038564704.1|2907605_2909093_+|altronate-dehydratase	gnl|CDD|377287	pfam04295, GD_AH_C, D-galactarate dehydratase / Altronate hydrolase, C-terminus. Family members include the C termini of D-galactarate dehydratase (EC:4.2.1.42) which is thought to catalyze the reaction D-galactarate = 5-keto-4-deoxy-D-glucarate + H2O, and altronate hydrolase (altronic acid hydratase, EC:4.2.1.7), which catalyzes D-altronate = 2-keto-2-deoxygluconate + H2O. As purified, both enzymes are catalytically inactive in the absence of added Fe2+, Mn2+, and beta-mercaptoethanol. Synergistic activation of altronate hydrolase activity is seen in the presence of both iron and manganese ions, suggesting that the enzyme may have two ion binding sites. Mn2+ appears to be part of the enzyme active centre, but the function of the single bound Fe2+ ion is unknown. The hydratase has no Fe-S core.	0
NZ_CP007451.1|WP_168136466.1|2915170_2916451_-|TldD/PmbA-family-protein	gnl|CDD|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	4.30753e-94
NZ_CP007451.1|WP_051567844.1|2906024_2907524_+|tagaturonate-reductase	gnl|CDD|235147	PRK03643, PRK03643, tagaturonate reductase.	0
NZ_CP007451.1|WP_157470801.1|2887793_2888558_+|IS5-family-transposase	gnl|CDD|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	3.2406e-15
NZ_CP007451.1|WP_038558694.1|2911304_2913632_+|sodium-translocating-pyrophosphatase	gnl|CDD|376979	pfam03030, H_PPase, Inorganic H+ pyrophosphatase. The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists.	0
NZ_CP007451.1|WP_038558669.1|2895681_2896767_+|glycine-cleavage-system-aminomethyltransferase-GcvT	gnl|CDD|234742	PRK00389, gcvT, glycine cleavage system aminomethyltransferase GcvT.	0
NZ_CP007451.1|WP_038558712.1|2919616_2920741_+|histidinol-phosphate-aminotransferase-family-protein	gnl|CDD|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	4.45316e-67
NZ_CP007451.1|WP_051567842.1|2895155_2895500_-|Hpt-domain-containing-protein	gnl|CDD|366732	pfam01627, Hpt, Hpt domain. The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to contain a binding surface for Ssk1p (response regulator receiver domain containing protein pfam00072).	1.02427e-07
NZ_CP007451.1|WP_038564706.1|2916567_2918094_-|TldD/PmbA-family-protein	gnl|CDD|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	3.10614e-130
NZ_CP007451.1|WP_038558680.1|2899632_2900883_+|DUF1015-domain-containing-protein	gnl|CDD|377633	pfam06245, DUF1015, Protein of unknown function (DUF1015). Family of proteins with unknown function found in archaea and bacteria.	0
NZ_CP007451.1|WP_038558715.1|2921043_2921901_-|HAD-IIA-family-hydrolase	gnl|CDD|319827	cd07525, HAD_like, uncharacterized family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.34799e-55
NZ_CP007451.1|WP_038558664.1|2892519_2895108_+|ATP-dependent-chaperone-ClpB	gnl|CDD|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP007451.1|WP_038558657.1|2888992_2891695_-|pyruvate,-phosphate-dikinase	gnl|CDD|236446	PRK09279, PRK09279, pyruvate phosphate dikinase; Provisional.	0
NZ_CP007451.1|WP_038558690.1|2909309_2910977_-|FAD-dependent-oxidoreductase	gnl|CDD|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	7.50497e-137
NZ_CP007451.1|WP_038558709.1|2918498_2919515_+|glutamine-synthetase-beta-grasp-domain-containing-protein	gnl|CDD|177922	PLN02284, PLN02284, glutamine synthetase.	2.48281e-134
NZ_CP007451.1|WP_051567843.1|2901278_2904254_+|pyruvate,-phosphate-dikinase	gnl|CDD|376527	pfam01326, PPDK_N, Pyruvate phosphate dikinase, PEP/pyruvate binding domain. This enzyme catalyzes the reversible conversion of ATP to AMP, pyrophosphate and phosphoenolpyruvate (PEP).	7.1429e-28
NZ_CP007451.1|WP_038558703.1|2914084_2915098_+|dihydroorotate-dehydrogenase-like-protein	gnl|CDD|236051	PRK07565, PRK07565, dihydroorotate dehydrogenase-like protein.	1.33366e-130
NZ_CP007451.1|WP_038558672.1|2897379_2898447_+|3-phosphoserine/phosphohydroxythreonine-transaminase	gnl|CDD|235428	PRK05355, PRK05355, 3-phosphoserine/phosphohydroxythreonine transaminase.	0
NZ_CP007451.1|WP_038558676.1|2898517_2899438_+|3-phosphoglycerate-dehydrogenase	gnl|CDD|240651	cd12174, PGDH_like_3, Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. Many, not all, members of this family are dimeric.	1.13729e-88

Protein sequences

>NZ_CP007451.1|WP_038558685.1|2904393_2905044_-|DUF4878-domain-containing-protein
MKKNLFAIIAIVTLCYCNSNQAEIERIHKEKIEVGKSLKITKLNNILKPLEENLSSQKQKLAKINEWQLGRTQTEKETQLAEQKQLISQIEFMKSRIENEIALSNMFQSFEFQNTPEGTIEQIFQAAKTEDYSKMRYLLDPYGEYDNDAFSICMIEMLPSESQKEMAEQFKNGRIMNNISTNDSTAIIEIAFGPSSNKLEQMHLVKRLNKWYISNF
>NZ_CP007451.1|WP_051567843.1|2901278_2904254_+|pyruvate,-phosphate-dikinase
MDIDNISLSTIYKKRKNDRDIFQELMPTKVKEVLLVATLYDSYSIVREGQFSDKIFGEYLQLNLYAAPRFTSVHTQEEALLILQHRDFDLIIVMAGMDKNTPVKTARAIRNVRPAVPLLLLVNNNADLRFFQAERRKLDFIDRIFVWNGNSNVFMAMIKYIEDKSNVARDTQNGSVRIILLVEDSIQYYSRYLPMLYTTVMTQTQVLVNEDATDELHKILRMRARPKVILVDNYEEAVKFINSYRRYMLCVISDVKFERNGVEDEDAGIDLLKFTQTTRKFPIPLLLQSHDISNAQRAKEVGADFINKNSESLSMDIFNFLYRRLGFGNFVFKGMDGLPIAQAKNLVEFQEKFRDIPEESLQYHGSRNSFSTWLMARGEINLAELLMPIQMSDFDSPEELRQFCLDSFKKIRFERLRGTIVNFDSEFVSSSRFIVRMAKGSLGGKGRGIAFICNFIENIDFAKLIPEMNIRIPSTSIIGALEFDKFIETNNLYDDIYSFNDYSAIRKHFLESEFDDKIRKRLIEYLKKIKRPLAVRSSGLFEDSLLQPFSGVYATYLIPNNHPDLEVRYQHLEMAIKLVYSSIFTESAQAYFDAVNYKIEEEKMAVVIQEVIGHEYNDKYYPTLSGVAQSYNYYPIAYMEPDDGFSVAAVGLGMYVVGGENSFRFCPKYPNLNASSLKDQLRDTQKQFYAIDLSNPDFDLASDGENAAIKKYRIKEAEKDGTLEHSASTYFIENDDLIPGIQGPGPKVIDFANILKYNHLPLADVLQLLLKLFKEAMGSPVEIEYAIDLEPAENGKPTLYLLQIKPLIRIEEQVEVDIEMVDDDKVFMYAEHGMGNGKIKDIYDVVFVDPDKFDKMKTRQMAQDISVLNDWFDEQERPYILIGPGRWGSRDPFTGIPVLWAHISKAKIIVEMGLPDFPLDASLGSHFFHNVTSMNVGYFSVPHNSRTAKLKMEALKEQPVLHETEFIKHVQFEQPLTILMNGRDRRVLIHC
>NZ_CP007451.1|WP_038558680.1|2899632_2900883_+|DUF1015-domain-containing-protein
MAIIKPFKGLRPQKEIVEELACLPYDVMNSEEAAVMAEGKEKSLLRITKAEIECPGVEDIHSETVYNKAVENFKAFQEKGWLQSDAEAKYYIYAQTMNGITQYGIVGAAACADYENGIIKKHELTRPEKEEDRMVLTRYLNANIEPVFFAYKAVAEIDAIVENIVKSKTADYDFTAEDGFGHHFWTIDDAETNVKLEQLFEEKVPFTYVADGHHRTAAAARIGAEKTGQNPNHKGDEEYNYFMAVHFPDNQLQIIDYNRVVTDLNGLSEVDFLAELSKGFDVENMGTEIFKPSALHEFSLYMAGSWYKLTAKEGTYDDSDPIGILDVTILSNQVLDPILDIKDLRTSKRIDFVGGIRGLAELKRRVDSGEMKAAFALYSVSMQQLINIADSGNIMPPKTTWFEPKLRSGLVIHKLD
>NZ_CP007451.1|WP_038558676.1|2898517_2899438_+|3-phosphoglycerate-dehydrogenase
MRKILIATEKPFAPVAVKKISKIFEKAGYELQLLEKYTEKQELLDAVANVEAAIIRSDKFDKEVLNAGKNLKIVVRAGAGYDNVDLDAATVNNIVVMNTPGQNSNAVAELAIGLAIMGLREMYSGKPGGEMRGRTLGLHGFGYVARNVFRIARAMGMKVIVYTRYSKGAAAAIGLKVAKSLEDLYEKSDIVSIHVPARGEHIKSVSSEVLCHLKDGSILVNTARKEVINEPDLVKCMEEKPGIKYMSDLTPDCEAEFEEKFPGRFFFTPKKAGAQTAEANLNAGLAAAQQIVDFFENGDNTHQVNK
>NZ_CP007451.1|WP_038558672.1|2897379_2898447_+|3-phosphoserine/phosphohydroxythreonine-transaminase
MKKHNFYAGPSILPEFTKEKTAEAALNFAGTGLSVMEVSHRSKEFVAVMDEAVALVKELLKVPEGYSVLFLQGGASTQFLMAPYNLMDKKAAYLNTGAWSKKAIKEAKFFGEVVEVASSADTIYNYIPKGYEVPTDVSYFHYTSNNTIYGTQVPTPDVDVPLVADMSSDIFSRPIDVSKYDLIYAGAQKNLGPSGATLVIVKDAALGKVERPIPTMLDYTTHIKAESMFNTPSTLPVFACLQTLIWLKENGGVEAMEQKNIEKAKVLYDEIDRNKLFQCTVLAPEDRSLMNVTFIMTPEYAELEKEFLEFATAKGMLGIKGHRSVGGFRASIYNAMPVESIQALVDAMQEFEKMK
>NZ_CP007451.1|WP_038558669.1|2895681_2896767_+|glycine-cleavage-system-aminomethyltransferase-GcvT
MKTTAFNSIHKKLGAKMVEFAGYEMPIEYSGIKDEHMTVREGVGVFDVSHMGEFWVKGPKALDLVAKIISNDPRVLTQGQAQYSCFPNGKGGIVDDLLVYFYEPEKYMLVVNAANIEKDWNWVVQQNEEIGAELENASDEISQLAIQGPKATEVLQKLTDVNLSEIKFYTFVTDKFAGVDEVIISATGYTGAGGFELYFRNDVAEKIWEAIFEAGAEAGIKPIGLAARDTLRLEMGYCLYGNDIDDTTSPLEAGLGWITKFNNGRKFIDREFLTMQKNEGVTRRLRGFVLTGRGIPRHGYELVNSDGETIGEVTSGTMSPVLNKGIGMGYVAKEYSAFGTGIFVKIRNKVIPAEIVKLPFI
>NZ_CP007451.1|WP_051567842.1|2895155_2895500_-|Hpt-domain-containing-protein
MDNIFQHINPSQLETLAGGDKEFIKEMAEIFLEQINEFVTNMSSFLQEKNWERLAREAHTAKSSAMTFGMDDTGTLLKNIQLECEAGNLNDVPKMVEDAINQLQAATPEVEELL
>NZ_CP007451.1|WP_038558664.1|2892519_2895108_+|ATP-dependent-chaperone-ClpB
MNFNNFTIKSQEAIQQAFQIAQGNNQQAIETGHILRGVLHSAENVTGFLLKKLDVNLTIFTQALDQIILSYPKVSGAEQYLSSGANQALQKALGLAQEMGDQYVSVEHILMALLEVKDNTSRLMKDNGIAKKELKLAVEELRKGSKVDSQTAEDKFNSLNRFAINLNERARSGKLDPVIGRDDEIRRILQILSRRTKNNPILLGEPGTGKTAIAEGLAHRIVRGDVPENLKSKQVFSLDMGALVAGAKYKGEFEERLKAVVNEVVQSNDEVILFIDEIHTLVGAGKGEGAMDAANILKPALARGELRAVGATTLAEYQKYFEKDKALERRFQIVHVNEPDTLSAISILRGIKEKYENHHKVQIKDDAIIASVELSQRYISDRFLPDKAIDLMDEAAAKLRLEIDSVPEELDEIQRRVKQLEIEREAIKRENDTKKLNSLNEEISNLKEEQSQLRAKWQSEKSAIEAIQKKKEEIETYKFEAEQAEREGDYGRVAELRYGKVKEVEAEIEKLQAELEEMKKGENLIKEEVDTEDIAEVVARWTGIPVSKMLQSEREKLLHMEDELHNRVIGQDEAIVAISDAVRRSRAGLQDEKRPIGSFIFLGTTGVGKTELAKALAEYLFNDENMITRIDMSEYQEKFSVTRLIGSPPGYVGYDEGGQLTEAVRHKPYSVVLFDEIEKAHPDVFNVLLQVLDDGRLTDNKGRTVNFKNTIIIMTSNLGSQIIQENYETMNDANEFQVLEQTRNQLLEMLRKTIRPEFLNRIDETIVFTPLSKEAIKEIVRLQFEQIVKRLASSELKIELSEKANEWLSTVGYDPHFGARPVKRVLQRFVLNELSKRILSGKVDKSKPIVIDYENDSLVFSN
>NZ_CP007451.1|WP_038558657.1|2888992_2891695_-|pyruvate,-phosphate-dikinase
MTKHVYTFGAGQAEGKADMKNLLGGKGANLAEMNLIGVPVPPGFTITTEVCTMYNEKGQQATFDLIKPEVEAAVALVEKLTGTEFGSKENPCLMSVRSGARASMPGMMDTVLNLGMNDDAVEGIAKKSGNPRFAWDSYRRFVQMYGDVVMDMKPASKEEHDPFEEIIDQLKEEKDIALDTQFTTEDLQELVNRFKAAVKKVTGKDFPTDPWEQLWGAVAAVFGSWNNPRAIYYRRMEQIPDEWGTAVNVQAMVFGNMGESSATGVAFTRDAATGEDVFNGEYLINAQGEDVVAGIRTPQEITKAGSLKWAALQGISEEERASKFPSLEETMPDLYTQLNETQQKLEDHYSDMQDLEFTIQEGKLWLLQTRNGKRTGAAMVNIAVDMLEEGRIDEKTALQRIDAAKLDELLHPVFDTAAMKAAKVLTKGLPASPGAATGQVVFFADEANKYPEAVLVRVETSPEDLEGMNIAKGILTARGGMTSHAAVVARGMGKCCVSGAGAVKINYKTRIMTIDGKEFKEGDWISLNGSTGEVYDGKVATMDPELSGNFAKIMDLADKFTRMTVRTNADSPADAQVARDFGAQGIGLCRTEHMFFEGERIKAMREMILAKTEVDRRKALDKLLPYQREDFEGILEAMAGYGVTIRLLDPPLHEFVPHEEANQKEMADEMGISVEKVKALVEDLHEFNPMLGHRGCRLGNTYPEITEMQARAIIEAAVNLKQKGVDARPEIMVPLIGTVKELKLQADIIHATAKKVFEEKGAECSYMVGTMIEIPRAAVTADKVAEVAEFFSFGTNDLTQMTFGYSRDDAGKFLPIYIEKGILKNDPFQVLDQEGVGQVVKMGVDRGRSTKPNLKVGICGEHGGEPSSVMFCDSVGMDYVSCSPYRVPIARVAAAQANIK
>NZ_CP007451.1|WP_157470801.1|2887793_2888558_+|IS5-family-transposase
MCPYLKFGNSKNNTKVRDYQVLEAILYRLKTGCQWRQLPMKQFFRCKYNWQSVYFHYQKWCKDGSWDEMWQNILNKYKHLLDLSSIQLDGTHTPTKRGGEAVAYQGRKKAKTSNMLILTDSQGIPLTCSDPIDGNHNDAYNLVPTAKKMIAVLENSGVHTDGLFLNADSGFDTEEFRHYCSETEIIGNIDQNKRNGINSEYLFDDLLYKCRFVVERTNAWLDAFKAILVRFETNATHWKALNLLAFTVILLRKL
>NZ_CP007451.1|WP_051567844.1|2906024_2907524_+|tagaturonate-reductase
MKKLNRTNATETTSYPTRILQFGEGNFLRAFTDWIVDKMNKEIGFNAGVDVVQPLPNGMVDMLNDQDGLYHVYLKGIKNGKPVTEFSLIDCINKGINPYSEFESYKESILNPDLRFVFSNTTEAGISWEDSDTLDMAPQNSFPAKVAAMLYMRYKEFDGDKSKGLIFFACELIDRNGDMLKKFVLQHAEKWNLGNDFISWVNEACCFCSTLVDRIVPGFPKDEIKEIQEELGYEDNLVVVGEYFHLWVIEAPEWVQDEFPAEKAGLEVKFVKDMKRFREQKVQVLNGCHTGSYAVSYLSGIETVRDAYENLEVGSFMKELVYDEVLTVLDGTEKELKKFANKILERFANPFIRHQWQSIALNAMSKWETRNLPSLINFEQKHGMLPQKLVFSLAAMIAYFKGEANGEAYNVQDDEWIVDFYKEAWAECDGRPISIYNLCEKVLSLDKVWKQNLNEIPNLTITVSHYLFLITQVGMKKAVKAVLSEDNPLMQITIDKMSN
>NZ_CP007451.1|WP_038564704.1|2907605_2909093_+|altronate-dehydratase
MADYIKINPTDNVIIALKDFSAGETIEVDGQKLTIVGDVPKGHKIALTAIAENEDIIKYGAPIGHATQDIEAGEYIHVQNLRTNLSGTINYSFDQKLNELAVAERELTFEGYKRSNGKVGIRNELWIVPTVGCVNGQAQQIIDLFKQEVNPTDIDAVEVFKHSYGCSQLGDDHVNTQKALADVINHPNAGGVFVMGLGCENNQIDHLKKFIGDYDESRVRFLASQDVEDEVETGLEILKEIYDVMHTDQREAVPLSELNIGLKCGGSDGFSGITANPLVGAFSDFLVAQGGTTILTEVPEMFGAETLLMERAENKEVFDKTVSLINDFKAYYLQHNLPVYENPSPGNKKGGISTLEDKSLGCTQKGGTATVVDVLKYAEPLKTKGLNLLSAPGNDLVAASALGFSGCQMVLFTTGRGTPFGSFVPTMKISTNSDLFNKKKNWIDFNAGTLLEGKTMDELLEDFVQFIIEVASGKKLNHEKTGFKEIAIFKTGVTL
>NZ_CP007451.1|WP_038558690.1|2909309_2910977_-|FAD-dependent-oxidoreductase
MKTKRLVTFFASFIFLFFSCQNKQEVSLTNADVVIYGGTSAAVTAAVQLAKMNKSVVIVCPDKHPGGLTSGGLGFTDTGNKSVIGGLARGFYQRVYSHYQTEEAWLWEKREEYGNTGQGTPAIDGDKRTMWIFEPHVAEQVFEDFISENNISVFRDRWLDRENGVEKQNGKIVFITMLNGETYKAKLFIDATYEGDLMAAAGINYHVGREANEVYNEQWNGIQTGVLHHGHHFGSMNISPYVVPGDPASGVLPRISTDDPGKKGDGDERIQAYCFRMCLTKVPDNRVPIEQPENYDPAQYELLVRVLNHGWRETFNKFDPIPNHKTDVNNHGPFSFDNIGMNYDYPEATYERRAEIIREHENYQKGLLYFYATDPRIPAEIQTEMQQWGLAKDEFTDNGNWPHQIYVREARRMIGEFVMTENEVLGKSQVPYSIGMGSYTMDSHNTQRFITPEGFVQNEGDIGVHPHQPYQIALGSILPKQEECKNLLVPVTVSSSHIAFGSIRMEPVFMILGQSAALLAGMALEEETPIHQLQYEEIKTKLEAAGQVLEHQEIE
>NZ_CP007451.1|WP_038558694.1|2911304_2913632_+|sodium-translocating-pyrophosphatase
MSSIFIIVPIASVLALVFAWFFFKSMMKNSEGTDRMKEIAQYVREGAMAYLKRQYKVVGIVFVILFILLTIMAYFGVQNPFVPIAFLTGGFFSGLCGFLGMKTATFASARTAHGASKSLNKGLQVAFRSGAVMGLIVVGFALLDIAAWYFFLSEVVFTPEHMANGAEFLGLHFVHGSADYVTNGVINDAGQRVKLIEITVTMLTFGMGASTQALFARVGGGIYTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDVAGMGADLYESYAGSILATAALGAALPVVVLSDTGIDPVKAVTAPMIVAAIGIILSIVGIFMVRTKESATQKNLLNALLIGTGGSSVLILIAMAGMAYLGWVTWGVFWAVIIGLAAGVIIGQATEYFTSDEYKPTKGIAEQAQQGPATTIIDGLAVGMYSTWIPVVTIVLGIMGSFWAAGGAEHFAMGVYGIGFAAVGMLSTLGITLATDAFGPIADNAGGNAEMAELPPEVRERTDALDMLGNTTAATGKGFAIGSAALTAMALISAYMEEIRLWFGKIATAGEGFVTKGSYIFYNDIAPAAQDGMQAIKISTASVKDFTAAYDVTLFNPLFLGGLFLGSMMAFLFSAMTMKAVGRAAGAMVDEVRRQFRDIKGILEGTATPEYAKCVEISTKGAQKEMLVPSLVAIIVPVIVGATMGVAGVIGLLAGGLTAGFTLAVFMNNAGGAWDNAKKYIEKGNYGGKGSEAHHAGVVGDTVGDPFKDTSGPSLNILIKLMTMVSVVMAGLTVTLSLL
>NZ_CP007451.1|WP_038558703.1|2914084_2915098_+|dihydroorotate-dehydrogenase-like-protein
MANLTTTYMGVELKNPLILGASNLVSKPEVIKQIEEAGIGAIVYRSLFEEQIQLESLQMDELLSEYEERNAEMTDLFPGLKHAGPKEHLYNVEKLVKSVDVPVFASLNAIYEPTWVEYAQELEKTGVAGLEINLYAVPGYFEVTGESIEDKQVQIVKAIKQVVKIPVSVKMSLFYTNPLNFIKKVDEAGADGYVLFNRFFQPEIDIEKEEYFYPWELSNPKDHMVGLRYAGLLYGNVEGSVCISRGIYDANDVIKMLLAGADVVQMVSTIYRNSPSVVSDILMDINKWMDDKGYKSLDDFRGKLSRKSMKDPFAYQRAQYVDILTKSEDIFKKYPMV
>NZ_CP007451.1|WP_168136466.1|2915170_2916451_-|TldD/PmbA-family-protein
MNHALENGAQEVSVNISNNQSSSVEVREEKIDKLEQALQSNLSIRLFVDKKYSSHSTSRLNKEDLARFIEEAIEGTKYLSEDEFRTLPDPELYYKGDGPDLGSLDENFGNVDPEEKIKLAFAAEKEILGSNERIISVSSSYYDGLNERVMVNSNGFEGDTANSYFGIYTNVSVKGDGDGRPESGWGETAIKYNELKKRGTGTIALKRALDKIGAKKIESGTMPMIVENRVVSRIFSPLINALDGSAIQQKNSFLIDKLGEKVASDKLTLTDDPFIIGGRGSRLFDGEGMATKKRTVFEKGVLKRYYIDTYYGKKLEMEPNSGATTNLVFETGDKDLDALIASVKKGIFVTGFNGGNSNGSTGDFSYGIEGFLVENGEIVKPVTEMNITGNMKTLWANIGEIGNDVREDSSWRTPSILFNDVDFSGL
>NZ_CP007451.1|WP_038564706.1|2916567_2918094_-|TldD/PmbA-family-protein
MKVDRRDFIKTSGMFAAGSMVLPPFVQSCQNVQISADVKSYLDHFEVTTEMLQKVIATAMSKGGDYADLFFEHKISNSLALEDGKVNRAYSNIDFGVGIRVLKGDQTGFAYSENIALDDMLNAAKMAANIANSSASFTAADYNEKLPANYYKISKKWEDVSVKDKVPFVQKVNDKIFSLDDKVIKVNAGMSDESSYVMFYNSEGRLTYDYRPMISFYAVCIMQDGEQIENAYSARSVRRGFEWLTDDLVDELANEAVEKTNLLFKAGKPKAGEMPVVLGAGGSGILLHEAIGHTFEADFNRKGTSIFSDKLNKKVAENFINIIDDGTLPNDRGAINIDDEGNDVQKTYLVKDGILNSYLHDRISAKYYGVEPTGNGRRESFRHMPLPRMRSTYMENGPHTTEEIFAAVDYGVYVDNFSNGEVKIGAGDFTFFVKSGYIIENGKLTTPIKDINIVGNGPQALADISMAANDYKNDSGTWTCGKDGQSVPVTLGLPTVLVKKMTVGGTNA
>NZ_CP007451.1|WP_038558709.1|2918498_2919515_+|glutamine-synthetase-beta-grasp-domain-containing-protein
MMKSKLEYIWLDGSVPTQQLRAKTRVADNFSGKLEDCPIWSFDGSSTNQAGGGASDLLLKPVFICPDPDRKNAYLVLTEVLNPDGSAHETNGRAHIEEEDEDFWFGFEQEYFLYDPQTRLPLGFPAGGFPLPQGPYYCGVGGSKAFGRAIVEEHFDLCLEAGLNVEGINAEVAAGQWEFQIFAKGAHSAGDQIWMARFLLERTAEKYGVDVEWHPKPLGKDLDWNGSGMHANFSNGLMRTCGDEKVFTAICEEFGKNIKEHIDVYGAYNDQRLTGLHETQSITEFSYGVSDRGASIRIPVGTVEDGWKGRLEDRRPASNGDPYKIGARIIKTVHAAKI
>NZ_CP007451.1|WP_038558712.1|2919616_2920741_+|histidinol-phosphate-aminotransferase-family-protein
MLRKQIEIKRELFDETSHSPSLVDIVGEEQLADVVDFCFIENPYFPGEALLQKLQDKLPEVIKAYPSSNPKLAQQDLAAVVHVNPEYLVLGNGATELITIIQNNFVEDMGIPVPTFSEYIEKVQNQQKVRLFQLPADKQYQLDLEEYADWLVDEEISSALIINPGNPTGQLLSVENITGFLNRMKHLKLVLLDESFIDFAGEEIPTLMPKVEQFQNLVIVRSMSKHCGVPGLRLGYCCTANEYYLRQIRNALPVWNINTLAEYFLTQLKDTDAEYHQARKHVISDVRELHKALAEINGYEVYPTNSNFILLKINFAMSAYDLQMKLLQDFGVYVRDCSNKTGLDDKHIRIASKGREKDQLLIHALKTVAVELSR
>NZ_CP007451.1|WP_038558715.1|2921043_2921901_-|HAD-IIA-family-hydrolase
MRTKSFRSVVKNYRAVFFDAFGVLKNHSGLIEGVGNTFNYLESKGIPYYVLTNDSSRSPEELSNWYQKRGLTTITTDKILSSGMLAMEFFKTKLENGKAVAYLGTKDSAHYLETAGQKTVPISEVDLNNLDHIKSFAFLDDEGFDWNKDIDKTINLLRHKNMTVIVANTDINYPVNKNDISVAIGGLADLVEQILGKKFIRFGKPDAQMFLLAYERAMQDVPNIQRNEILMVGDTLFTDIIGGNKFGLDTVLVLSGNTLPDNAKIKIIGSGIIPTYVCDSAVIEP

Crispr_ID: NZ_CP007451_7

• CRISPR_ID: NZ_CP007451_7
• CRISPR_location: 3906757-3906831
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP007451_7

Consensus_repeat	Method
TGACCTTGCACCTTTGGCGCAAAT	CRISPRCasFinder

spacers of NZ_CP007451_7

>7.1|3906781|27|NZ_CP007451|CRISPRCasFinder
ATGCATAGCCCTGCGGACTATGCTAAA

CRISPR arrays and Neighbor proteins around NZ_CP007451_7

CRISPR arrays

The CRISPR arrays of NZ_CP007451_7

>merge|NZ_CP007451|7|3906757-3906831|CRISPRCasFinder
TGACCTTGCACCTTTGGCGCAAATATGCATAGCCCTGCGGACTATGCTAAATGACCTTGCACCTTTGGCGCAAAT

>NZ_CP007451|7|5|3906757-3906831|CRISPRCasFinder
TGACCTTGCACCTTTGGCGCAAAT	ATGCATAGCCCTGCGGACTATGCTAAA
TGACCTTGCACCTTTGGCGCAAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007451.1|WP_038560859.1|3910846_3912028_-|ATP-binding-protein	unknown	unknown	gnl|CDD|379049
NZ_CP007451.1|WP_051567942.1|3917243_3917603_-|SoxR-reducing-system-RseC-family-protein	unknown	unknown	gnl|CDD|377263
NZ_CP007451.1|WP_038565117.1|3913352_3913955_-|RnfABCDGE-type-electron-transport-complex-subunit-G	unknown	unknown	gnl|CDD|273889
NZ_CP007451.1|WP_038560867.1|3913956_3914934_-|RnfABCDGE-type-electron-transport-complex-subunit-D	unknown	unknown	gnl|CDD|376991
NZ_CP007451.1|WP_074781029.1|3899204_3899771_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_074781026.1|3897570_3898239_+|PorT-family-protein	unknown	unknown	gnl|CDD|372635
NZ_CP007451.1|WP_038560857.1|3907046_3910610_-|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase	unknown	unknown	gnl|CDD|131231
NZ_CP007451.1|WP_081804880.1|3893729_3895454_+|acyltransferase-family-protein	unknown	unknown	gnl|CDD|293786
NZ_CP007451.1|WP_038560836.1|3897320_3897515_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038560870.1|3915037_3916369_-|electron-transport-complex-subunit-RsxC	unknown	unknown	gnl|CDD|273888
NZ_CP007451.1|WP_038560852.1|3902810_3905849_+|glycoside-hydrolase-family-127-protein	unknown	unknown	gnl|CDD|369609
NZ_CP007451.1|WP_038560847.1|3900110_3900827_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038560854.1|3906229_3906682_+|IS200/IS605-family-transposase	unknown	unknown	gnl|CDD|376616
NZ_CP007451.1|WP_038560862.1|3912174_3912747_-|electron-transport-complex-subunit-RsxA	unknown	unknown	gnl|CDD|130998
NZ_CP007451.1|WP_038560841.1|3898800_3899148_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038560834.1|3895798_3896878_+|IS110-family-transposase	unknown	unknown	gnl|CDD|376773
NZ_CP007451.1|WP_038560863.1|3912758_3913343_-|electron-transport-complex-subunit-E	unknown	unknown	gnl|CDD|237091
NZ_CP007451.1|WP_038560873.1|3916375_3917242_-|Fe-S-cluster-domain-containing-protein	unknown	unknown	gnl|CDD|235941
NZ_CP007451.1|WP_174416385.1|3901742_3902060_+|DUF4440-domain-containing-protein	unknown	unknown	gnl|CDD|379639
NZ_CP007451.1|WP_038560881.1|3917941_3919834_-|cation:proton-antiporter	unknown	unknown	gnl|CDD|235131

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP007451.1|WP_038560859.1|3910846_3912028_-|ATP-binding-protein	gnl|CDD|379049	pfam13173, AAA_14, AAA domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	6.83057e-24
NZ_CP007451.1|WP_051567942.1|3917243_3917603_-|SoxR-reducing-system-RseC-family-protein	gnl|CDD|377263	pfam04246, RseC_MucC, Positive regulator of sigma(E), RseC/MucC. This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions). In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteristic of chronic respiratory tract colonisation in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain pfam02424, which is itself involved in thiamine biosynthesis.	4.9833e-20
NZ_CP007451.1|WP_038560867.1|3913956_3914934_-|RnfABCDGE-type-electron-transport-complex-subunit-D	gnl|CDD|376991	pfam03116, NQR2_RnfD_RnfE, NQR2, RnfD, RnfE family. This family of bacterial proteins includes a sodium-translocating NADH-ubiquinone oxidoreductase (i.e. a respiration linked sodium pump). In Vibrio cholerae, it negatively regulates the expression of virulence factors through inhibiting (by an unknown mechanism) the transcription of the transcriptional activator ToxT. The family also includes proteins involved in nitrogen fixation, RnfD and RnfE. The similarity of these proteins to NADH-ubiquinone oxidoreductases was previously noted.	2.08661e-143
NZ_CP007451.1|WP_038560863.1|3912758_3913343_-|electron-transport-complex-subunit-E	gnl|CDD|237091	PRK12405, PRK12405, electron transport complex RsxE subunit; Provisional.	5.22788e-104
NZ_CP007451.1|WP_081804880.1|3893729_3895454_+|acyltransferase-family-protein	gnl|CDD|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	3.15672e-25
NZ_CP007451.1|WP_074781026.1|3897570_3898239_+|PorT-family-protein	gnl|CDD|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	3.79795e-15
NZ_CP007451.1|WP_038560857.1|3907046_3910610_-|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase	gnl|CDD|131231	TIGR02176, pyruvate_flavodoxin/ferrodoxin_oxidoreductase, pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric. This model represents a single chain form of pyruvate:ferredoxin (or flavodoxin) oxidoreductase. This enzyme may transfer electrons to nitrogenase in nitrogen-fixing species. Portions of this protein are homologous to gamma subunit of the four subunit pyruvate:ferredoxin (flavodoxin) oxidoreductase.	0
NZ_CP007451.1|WP_038560834.1|3895798_3896878_+|IS110-family-transposase	gnl|CDD|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.14609e-24
NZ_CP007451.1|WP_038560870.1|3915037_3916369_-|electron-transport-complex-subunit-RsxC	gnl|CDD|273888	TIGR01945, Electron_transport_complex_subunit_C, electron transport complex, RnfABCDGE type, C subunit. The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the C subunit. [Energy metabolism, Electron transport].	0
NZ_CP007451.1|WP_038560852.1|3902810_3905849_+|glycoside-hydrolase-family-127-protein	gnl|CDD|369609	pfam07944, Glyco_hydro_127, Beta-L-arabinofuranosidase, GH127. One member of this family, from Bidobacterium longicum, UniProtKB:E8MGH8, has been characterized as an unusual beta-L-arabinofuranosidase enzyme, EC:3.2.1.185. It rleases l-arabinose from the l-arabinofuranose (Araf)-beta1,2-Araf disaccharide and also transglycosylates 1-alkanols with retention of the anomeric configuration. Terminal beta-l-arabinofuranosyl residues have been found in arabinogalactan proteins from a mumber of different plantt species. beta-l-Arabinofuranosyl linkages with 1-4 arabinofuranosides are also found in the sugar chains of extensin and solanaceous lectins, hydroxyproline (Hyp)2-rich glycoproteins that are widely observed in plant cell wall fractions. The critical residue for catalytic activity is Glu-338, in a ET/SCAS sequence context.	1.01871e-119
NZ_CP007451.1|WP_038560854.1|3906229_3906682_+|IS200/IS605-family-transposase	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	2.54384e-26
NZ_CP007451.1|WP_038560862.1|3912174_3912747_-|electron-transport-complex-subunit-RsxA	gnl|CDD|130998	TIGR01943, Electron_transport_complex_protein_rnfA., electron transport complex, RnfABCDGE type, A subunit. The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the A subunit. [Energy metabolism, Electron transport].	9.4216e-79
NZ_CP007451.1|WP_038565117.1|3913352_3913955_-|RnfABCDGE-type-electron-transport-complex-subunit-G	gnl|CDD|273889	TIGR01947, Electron_transport_complex_subunit_G, electron transport complex, RnfABCDGE type, G subunit. The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the A subunit. [Energy metabolism, Electron transport].	3.97582e-43
NZ_CP007451.1|WP_038560873.1|3916375_3917242_-|Fe-S-cluster-domain-containing-protein	gnl|CDD|235941	PRK07118, PRK07118, Fe-S cluster domain-containing protein.	1.53619e-115
NZ_CP007451.1|WP_174416385.1|3901742_3902060_+|DUF4440-domain-containing-protein	gnl|CDD|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	6.79871e-19
NZ_CP007451.1|WP_038560881.1|3917941_3919834_-|cation:proton-antiporter	gnl|CDD|235131	PRK03562, PRK03562, glutathione-regulated potassium-efflux system protein KefC; Provisional.	0

Protein sequences

>NZ_CP007451.1|WP_038560854.1|3906229_3906682_+|IS200/IS605-family-transposase
MPQSLVKNYVHLTFSTKNRYPLITESIKAELFDYLGGVCKELESQPIIVGGVNDHVHLLFNLSRKIALMSLVEKLKTHSSKWIKGKGAEFADFYWQHGYGAFSVNPKQVEIVREYIQNQEMHHKTRAFKEEYRQFLKEYAVEYDERFVWD
>NZ_CP007451.1|WP_038560852.1|3902810_3905849_+|glycoside-hydrolase-family-127-protein
MKRLKPIVAIILALWAWSTKGVSAQSGDQMLDGIGETGLIARYTLEENAKDWSRNNLHGNIQGSGYEFIDDEMFGKVIALSGDGKTYITIPGELLAGEESLSISAWVYLRSAEGAAPLFDFGKNGKSTFSAAPAGDNGFMAQVGAYNTNSEAAALNKWNHVVVVINVPEKSFATYLNAEKVSEVKDVEVELKQLFDGRKGNDDQFVIGKSLAANNASLDAKLHDFRIYRIPLNGRQIGWINFSALHKEEAEEMMRNRQEAELQEFPETTPQLYNVYLTEVPTIEVETEVGFLPRLPRFVKGVYSNNFDGPEVRVLWPSPEDNSVVQKPGKYTVTGRVAGTAIQPKAIVTVVEHNHDHAAPHRTLEAFNLDEVQLTADLHNHETKFMENRDKFVKGLLVTNPDNFLYMFRNAFGQEQPAGAEPLGVWDSQETKLRGHATGHYLSALAQAYSSAAYDPAIQTGFAQKMEYMVNTLYELSHLSGTPKTAGGESVSDPLAVPPGPGKVDFDSDLSEDGIRTDYWNWGKGFISAYPPDQFIMLEHGAKYGTDNDKVWAPYYTLHKILAGLMDIYEVSGNKKALDIVEGMGDWVHARLSVVPTETLISIWNTYIAGEFGGMNEALARLSRLTNEPRYLETAKLFDNIRVFFGDAEHSHGLAKNVDMFRGLHANQHIPQIMGALEIYRDSKDPEYFDIADNFWNKATGDYMYSIGGVAGARNPANAECFTAQPATLYENGFSVGGQNETCATYNMLKLSRNLFLYNQQAELMDYYERGLYNHILASVDEDSPANTYHVPLRAGSVKQFSNADMDGFTCCNGTALESNTKLQNSIYFRSADNDALYVNLYVPSILKWTDKDITLTQTTAYPKEDHTTLTINGRGKFDLNVRVPHWATKGFFVTVNGKKQEVKAEPGTYLTISRKWKDGDKVELRMPFHFYLEPVMDQQNVASLFYGPVLLAAQEDGPRKEWRKVTLDADDISKSISGDPQKLEFEIDGVVYKPFYETYGRHSVYLDVTLK
>NZ_CP007451.1|WP_174416385.1|3901742_3902060_+|DUF4440-domain-containing-protein
MSDKNVAKLKNLFHENSVFVHMGGSWGKEQEINIIESGGIHYKNAEIHEVSANVIGDTAILLNRITLLAVVGGNEVTNPFMVTEVYKKENDEWKLASLSFTKLLN
>NZ_CP007451.1|WP_038560847.1|3900110_3900827_-|hypothetical-protein
MIQKLNSKSRVTEVDAACMRIIGAYQNTSLSTDVHLAAMFSALEPLSVSLSGSINRITAESNLEEKDEERDEPLRSLFYLVAGFLHHPDATIRAAAEKVNAVIERYGMGITKESYAVESSLVSSMLKDLAQPKLQDAIALLSGCAEIIAALQLAQTAFETARIAYEEEKADDSTQQSASEIKVEVLELVNKKIVVYLRAMEVVDVETFGAFARTVAEIIADNNQAVRKRLSKPEPVEE
>NZ_CP007451.1|WP_074781029.1|3899204_3899771_+|hypothetical-protein
MGLEDFYNLIRRQEEMEKLYAERYEGFSRELPAALTSVVFDYWPEMAENPVKYKPLLFNIGEKYIREIWEEYNNCYSLNRRSGPMADLHPVDTIDKLKLKYEKRCQELKRTYPDAGDEFWDEIIKEDYEREKKDIVFKLAVHEKMKAVFNAHYIDDVMEFESHILRYFERGMYLMCALRYVDEVYSLK
>NZ_CP007451.1|WP_038560841.1|3898800_3899148_+|hypothetical-protein
MNISGNWTYNEDFEYGNSVGEVELTQSGNEVSGVFSFTEAVENNYSIQVTEKVKGTIIDGKLLLESVEVKALQNGREISYLPNTFETHRITENQIIGSTFDSENVCGIFVLERKV
>NZ_CP007451.1|WP_074781026.1|3897570_3898239_+|PorT-family-protein
MKTLVQVLTAILLSTITSTVFAQTIGIKAGYTLSDMLIKEDGEIMNEALNMRSGLHFGPTFEWGIGEGAGIETALLLTTKGIKMNESESFESIAYSINSKVNLWYLDIPVFGKLYTNLNGIKVYGMFGPYIGIGLNGKTKVEETNGTENFSEEWDIVWGANEDDDLKRLGLGLAVGGGIEVSSFVVEFTSHFGLNNISPQADDDVVARNRSFMFSLGYKFRK
>NZ_CP007451.1|WP_038560836.1|3897320_3897515_+|hypothetical-protein
MKNTCSARKEARTLLFKLGCTGAIFAVVNKNFGQRDSEEEKATGPLCGEVLQESHLIHRFFNPT
>NZ_CP007451.1|WP_038560834.1|3895798_3896878_+|IS110-family-transposase
MQGKVKIISFQGQNIYIGIDAHLKNWTVTVMTENSLTKTISQDPDAGTLYTYLQRTFPGGNYLSAYEAGFCGFSAHRNLEKYGIKSIVVNPADIPTTDKERKQKEDRRDSRKIARSLKNGELTGIHVPDKETEELRSLVRYRKTLVKEISRHKSRIKSHLHCFGIAIPGPLAQASTYWSGKFTQWLEEVQQSTPYGGMVLQSTLATVKHLRAELLKINRKLRELEKEVMYGFKIKLLRSIPGIGLIVAVTLLSELETILRFKNLDKLCSFVGLVPRTNTSGENDKTGKITSRSNKPLRGIIIEAAWIASRNDPALAQCYLELCKRMKPNKAIIKIAKKLLNRIRYVMKNEKEYVHSVVQ
>NZ_CP007451.1|WP_081804880.1|3893729_3895454_+|acyltransferase-family-protein
MKIRIYFLDHLRTLMIFLVVVLHSGLVYEHVLQNSWIVVDPVKANSIGMIRLYLDLFIMFTIFFISGYLVPMSLKSKTAIEFIQSKVKRILIPWVIAVFTLIPAYKFIFLYSRGLPQEEWFSYFHFFERAGSDLSFYANNPAQNWLWFLPVLFMFQVIYLALAKTKVLLLKINLKTAVIVMFVVGVVSSVIIAQLGLNGWYDSAILHFQRERLLVYFMSFLLGSLCYKLKVFESTKKNKRLYIIANVVLTFTLGIFTAVALNTFFNIIDPQRNYYFISQFADRVAYYAFGLASQFTLLYIFLYGFRHSLNKRYVLMDELNRNSYSVYIIHTIVLGVVALSLMALPVPPMVKFLMVTILTFGLSNLLIYSWRTIRQREINTKTVATAILSLVIVMAAFTAYPETTNTEEQQTETTETSPAPQSGNSIHAAVIAGDVEAVKAIIASGADLNEKEPAGGSSPLMTACVFGKTEIAQVLIESGADLNVTNNDGSTALHTAAFFCRTEIVKALLNKGIDTSVVNNSGATAAQSVMAPFEAVKGIYEYFARVYEPLGLQLDPNRIEKTRPEIAEMISTNS
>NZ_CP007451.1|WP_038560857.1|3907046_3910610_-|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase
MAKQKKMVTCDGNYAAAYMSYMFSEVACIYPITPSSTMAEYVDEWAAFGKKNMFGRPVRLAEMQSEAGAAGAVHGALQSGALTSTYTASQGLLLMIPNMYKIAGELLPTVFHVSARALAGHALSIFGDHSDVYAARQTGFAMLAAGSVQEEMDLAGVAHLATLKSRVPFLAFFDGFRTSHEIQKIEAIAQEDIVPLVDMEAIQEFRNRALNPENPVTRGTAQNPDIFFQAKESANKFYDAVPDIVADYMDQISEITGRKYRPFTYYGAPDAENIIIAMGSVTETIKETIDYLTAQGKKVGLMSVHLFRPFSAKHFVEALPDSVKRIAVLDRAAEPGSTGEPLFLDVQSQFYGKENAPVIVGGRYGLGSKDTTPSQILSVYENLEMKEPKGNFTIGIVDDVTFKSLPLKEEINMTPEGTYQAKFYGLGSDGTVGANKNSIKIIGDATDKYCQGYFQYDSKKSGGFTCSHLRFGDKPIRSTYLVTTPDFVACHVPAYVNMYDVLKGLKKGGSFLLNSINDAEETKKQLPDAMKKYLAENEINFYIINGTKLGEEIGLGTRTNTIMQSAFFKITEVIPYEMAVEQMKAAIVKSYGKKGEHIVNMNYAAVDAGGKNVVKVDVPAEWAAIVVAEEAAVDADRPEYITKVVDVINAQKGDDLPVSTFAGSEDGQFPLGTAAYEKRGIAVNVPEWQVENCIQCNQCAYVCPHAAIRPFLMTEEEVEAAPAGTETKTATPAKVFGGLNFRIQVSPLDCTGCGNCADVCPSKVKSLVMKPLATQQAEVGRWDYMDQKVTVKETVVDKTKSVKNSQFAQPLFEFSGACAGCGETPYIKLITQLYGERMMVANATGCSSIYGGSAPSTPYCKHKQSGHGPAWANSLFEDNAEYGFGFAEGVSAQRDRIADIMTTALSNGASDAEKEVFGEWLEQKDNAEGSVVASKKVLDAIGASDSQYAKDILSLKQYLVKKSIWVFGGDGWAYDIGYGGLDHVMASGEDVNVLVMDTEVYSNTGGQSSKSTPVGAVAKFAASGKKVRKKDLGAMMMSYGYVYVAQVAMGANQSQYFKALKEAEAYPGPSIIIAYSPCINHGLRSSMGRTQEEEKKAVESGYWHLFRYNPLLEEEGKNPFQLDSKAPEWTKFQDFLNGEVRYTSLKKSFPAEADELFAAAEDNAKWRYASYQRMAAMDYSKPEEGEE
>NZ_CP007451.1|WP_038560859.1|3910846_3912028_-|ATP-binding-protein
MEFFQQVHKSLLQGSKDTIQRELMNNIDWNQRLICIKGFRSVGKTTFLLDYIKTHHPDSNDVLYLNLNNFYFTKRKISSFADEFAKRGGKVLLLDQIQKYPDWSADLRKCLDEIPDLKIIFTSSPVLRITEDNPDLEGMASIYHLEGLSFREYLNHETGSNFRTYTLEEILNNHIEIAQKVVDEIRPLAYFDEYLRHGYFPYYIHDPNFYIDKLLKNINLALEIDVPYINQIEFKYLPKLRKLLHIIASETPFTPNVSKLASSVETSRATIMNYLKYLKHARLINLLYENGGSDDDQMKKPDKVYMQNTNLLNAIAPNNFDKATVRQTFFYNQVGYVCELAKSPVADFCVNGKYKFNVGGRKLKPEKGIYAASDVIEVGEGNKIPLWLFGFLY
>NZ_CP007451.1|WP_038560862.1|3912174_3912747_-|electron-transport-complex-subunit-RsxA
MNYLVIVIGAILVNNIVLMQFLGICPFLGVSKKVSTGIGMTGAVAFVMILATIVTYLIQNYVLEKFGLGFLQTIAFILVIASLVQMVEIILKKVSPPLYQALGIFLPLITTNCAILGVAILTVQNEFNLLEGVIFSTSHAIGFGLALIIFAGIREHLDLQNVPKGLKGTPIALIAAGILAMAFMGFSGLV
>NZ_CP007451.1|WP_038560863.1|3912758_3913343_-|electron-transport-complex-subunit-E
MNQWKNFSKGFLKENPVFVLLLGMCPTLGVTSSAINGLGMGLATTFVLLMSNIVVSLVKNAIPEKVRIPSFIVIIAAFVTVVQLLMQAFVPALYKSLGLFIPLIVVNCIVLGRAEAFASKNNVVSSAIDGLGIGLGFTFALVLLGSIREILGSGKLFNITIYPENYVTLVFVLAPGAFIVLGYLIALINRMKKN
>NZ_CP007451.1|WP_038565117.1|3913352_3913955_-|RnfABCDGE-type-electron-transport-complex-subunit-G
MAKRESSFINMVLTLVLVTGIAAAVLGFVYDFTKGPIEVAKLKAQTEAIKTVLPEFDELGETMVLSPGEGQDSLEFFPAYKNGELVGTAIKTYTKSGFSGFISIMAGIDKDGNFSGYSVLEHAETPGLGSKMGVWFSNPEKPNQYVIGKNPETTNFTVSKDGGDIDAITASTISSRAFLDALTRAYSTYKNNKTTGDSGQ
>NZ_CP007451.1|WP_038560867.1|3913956_3914934_-|RnfABCDGE-type-electron-transport-complex-subunit-D
MSKLLTVSPSPHVHSSESTQKIMLRVVYAMIPAMLWGIYMFGLDAVRVGLISILSCLAIEFLIQKYIMKVKPSITDGSALITGVLLAFNVPVSLPWWIIIIGAIAAMGVGKLSFGGLGSNVFNPALVGRVFLLISFPVQMTSWPATRMMSVDSVSAATPLAVIKEGIKNGIPVSQLQGLPDLSDMAIGFNNGSMGEISAILLIIGGLYMLWKKVITWQTPVSIILTVLVVSGIFWLINPEMYVNPVYHVITGGLMLGAIFMATDMVTSPMTGKGQLIYGVGIGLITISIRMFGAYPEGISFAILIMNAFVPLINMYVKPKRFGGQ
>NZ_CP007451.1|WP_038560870.1|3915037_3916369_-|electron-transport-complex-subunit-RsxC
MLKTFKIGGVHPPENKLSKDKKIEVLPLPKTVFIPVAQHIGAPATPVVKKGDEVKVGQVIAQSSSFVSTNIHSSVSGKVTKVDFSADSSGYPKQGIFIAVDGDEWIEGIDRSEDLVKEISVDGPEIVKKIQEAGIVGLGGATFPTHVKLVPPKGMKAEVLLINGVECEPYLTSDHRLMLEKADEIMVGIQLLMKAMGVDKAVIGIENNKPDAIKLLNEKCSAYKGVSVQPLKVQYPQGGEKQLINAVTGKEVPSGALPIAVGAVVSNVGTAFAVYEAIQKNKPLFERVVTVTGKGLEKPSNFLVRVGTATSELIEAAGGVPENTGKIISGGPMMGRAIASLDVPVTKGTSGLLLIQEEESKREEIQACIRCSRCTSVCPMGLEPYLLMTLGEKQIFDRAENERIMDCIECGSCSYTCPSSRPLLDYIRFGKGKVGAMIRSRKK
>NZ_CP007451.1|WP_038560873.1|3916375_3917242_-|Fe-S-cluster-domain-containing-protein
MSITVVYTIVTLAVIGAAAAVILYFVAQKFKVVEDPRIDDVDEALPGANCGGCGYAGCRAFAEACVKASALGDLNCPVGGNETMNNVASILGLEAVKKDPRVAYIRCNGTCEHRPKTSSFDGATTCAIASSVYSGESGCQYGCLGYGDCYDACDFDAIVMHPETGIPEIIDDKCVACGACVDACPKDLIELRKKMPKNRKVVVSCRNQDKGGVARKACSVACIGCGKCVKECPFDAITMENNLAYIDSDKCKLCRKCVAVCPTGAIIEENFPPRKVKPVEKKETKPVN
>NZ_CP007451.1|WP_051567942.1|3917243_3917603_-|SoxR-reducing-system-RseC-family-protein
MNIVSQSACSTCHAQGACSVSDFQDKEIEVTEYKGNYKIGDEVTILFKQSKGFTALTWGYVVPFFVVLSTLIIALEVTGDELKSGLLSLFILVPYYITLYFFRHLLKKVLKFELEENAE
>NZ_CP007451.1|WP_038560881.1|3917941_3919834_-|cation:proton-antiporter
MHNQEFFLNALIYLGAAVVSVPIAKKLGLGSVLGYLLAGIIIGPFVLRLVGNEAGEVMHFAEFGVVLMLFIIGLELEPKLLWKMRRNIFGLGGLQVLITAGIITGVALLFNFQLNRAVAIGLILALSSTAIVLQTLSEKGLMRNIAGRSAFSVLLFQDMAVIPILALLPLIATLGTPATLSDTSMKSIGQVAQLPGWLQLLIIIGAIVVLVIIGRFAARHIFRLVAETGLHEVFVALALLMVIGIALGMDAIGLSPALGTFIAGVVLADSEYRHELETTIDPFKGLLLGLFFISVGAGINFNLLIENPWVIIGFVLLLIFIKFVVLLILGRIFRLKKGFEFLFAFLLAQASEFAFVLISFSKQNKLFDDKTSGMLLLVVTLSMAISPLLLIFNDKAVSPILARWQNKLEYDEIEEEETPVILAGFGRFGLTVGRILLANGFKVTILDNNPSNVETLRKYGFKLYFGDITRPTMLEKAGIEKARMLILSMAEHENALKVAEIVHKKYPHVKILARANDIFHVFEYLNLNITNTERENFHSAAELGSKALVELGFSKYEAYRAARMFKHHESQVTEELYRHWLEDQGKFIQETRRFEEQVKETLQAEKNYSIHETDCAWDVDSLKDEAQKEE

Crispr_ID: NZ_CP007451_8

• CRISPR_ID: NZ_CP007451_8
• CRISPR_location: 4017666-4017964
• CRISPR_type: TypeII
• Repeat_type: NA
• Spacer_info: 4 spacers
• Cas_protein_info: cas2,cas1,cas9

Consensus repeat of NZ_CP007451_8

Consensus_repeat	Method
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACC	CRISPRCasFinder
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACC	CRT

spacers of NZ_CP007451_8

>8.1|4017702|30|NZ_CP007451|CRISPRCasFinder,CRT
GCTATTGCTGATTATTTCAATCCAACTTAC
>8.2|4017768|29|NZ_CP007451|CRISPRCasFinder,CRT
TACAGGGAAACATTAAAGAGCTGATCCCA
>8.3|4017833|30|NZ_CP007451|CRISPRCasFinder,CRT
ACACCATACTTCCGTAACTGTCGGCTCGGC
>8.4|4017899|30|NZ_CP007451|CRISPRCasFinder,CRT
TGAAACATCATTAATATCGTTATGACAGAA

CRISPR arrays and Neighbor proteins around NZ_CP007451_8

CRISPR arrays

The CRISPR arrays of NZ_CP007451_8

>merge|NZ_CP007451|8|4017666-4017964|CRISPRCasFinder,CRT
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACCGCTATTGCTGATTATTTCAATCCAACTTACGTTGTGGTTTGATGTAAAATTGAAATGATATTCACCTACAGGGAAACATTAAAGAGCTGATCCCAGTTGTGGTTTGATGTAAAATTGAAATGATATTCACCACACCATACTTCCGTAACTGTCGGCTCGGCGTTGTGGTTTGATGTAAAATTGAAATGATATTCACCTGAAACATCATTAATATCGTTATGACAGAAGTTGTGGTTTGATGTAAAATTGGTGAAATTTGTAAT

>NZ_CP007451|8|6|4017666-4017964|CRISPRCasFinder
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACC	GCTATTGCTGATTATTTCAATCCAACTTAC
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACC	TACAGGGAAACATTAAAGAGCTGATCCCA
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACC	ACACCATACTTCCGTAACTGTCGGCTCGGC
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACC	TGAAACATCATTAATATCGTTATGACAGAA
GTTGTGGTTTGATGTAAAATTGGTGAAATTTGTAAT

>NZ_CP007451|8|2|4017666-4017964|CRT
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACC	GCTATTGCTGATTATTTCAATCCAACTTAC
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACC	TACAGGGAAACATTAAAGAGCTGATCCCA
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACC	ACACCATACTTCCGTAACTGTCGGCTCGGC
GTTGTGGTTTGATGTAAAATTGAAATGATATTCACC	TGAAACATCATTAATATCGTTATGACAGAA
GTTGTGGTTTGATGTAAAATTGGTGAAATTTGTAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007451.1|WP_038561132.1|4006910_4007654_-|outer-membrane-lipoprotein-sorting-protein	unknown	unknown	gnl|CDD|319986
NZ_CP007451.1|WP_051567956.1|4011966_4014168_+|hypothetical-protein	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|273840
NZ_CP007451.1|WP_038561190.1|4030075_4030558_+|PaaI-family-thioesterase	unknown	unknown	gnl|CDD|239527
NZ_CP007451.1|WP_038561187.1|4029071_4029890_+|prohibitin-family-protein	unknown	unknown	gnl|CDD|259799
NZ_CP007451.1|WP_038561182.1|4024935_4025472_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP007451.1|WP_051567955.1|4011224_4012001_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_139177988.1|4014360_4014561_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038561147.1|4016153_4017044_+|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|274694
NZ_CP007451.1|WP_038561153.1|4018014_4018971_-|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl|CDD|223088
NZ_CP007451.1|WP_038561141.1|4014757_4015414_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038561162.1|4021707_4022259_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|380339
NZ_CP007451.1|WP_038561179.1|4023247_4024822_-|peptide-chain-release-factor-3	unknown	unknown	gnl|CDD|179105
NZ_CP007451.1|WP_038561135.1|4008081_4009854_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038561150.1|4017107_4017446_+|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|226043
NZ_CP007451.1|WP_038561144.1|4015477_4016101_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038561176.1|4022532_4023105_-|DUF2179-domain-containing-protein	unknown	unknown	gnl|CDD|235234
NZ_CP007451.1|WP_038561185.1|4027793_4028906_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	unknown	unknown	gnl|CDD|336781
NZ_CP007451.1|WP_038561159.1|4019582_4021544_-|DUF4914-family-protein	unknown	unknown	gnl|CDD|379810
NZ_CP007451.1|WP_038561156.1|4019140_4019614_-|AIR-carboxylase-family-protein	unknown	unknown	gnl|CDD|376377
NZ_CP007451.1|WP_157470842.1|4010176_4011106_+|hypothetical-protein	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl|CDD|187774

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP007451.1|WP_051567956.1|4011966_4014168_+|hypothetical-protein	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	3.7e-39	129.5	15.4
NZ_CP007451.1|WP_038561150.1|4017107_4017446_+|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	1.9e-30	100.2	0.0
NZ_CP007451.1|WP_038561147.1|4016153_4017044_+|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	9.3e-85	278.8	0.0
NZ_CP007451.1|WP_157470842.1|4010176_4011106_+|hypothetical-protein	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	1.9e-25	83.7	3.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP007451.1|WP_038561132.1|4006910_4007654_-|outer-membrane-lipoprotein-sorting-protein	gnl|CDD|319986	cd16329, LolA_like, proteins similar to periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB. This family contains uncharacterized proteins similar to the periplasmic molecular chaperone LolA, the outer membrane lipoprotein receptor LolB and the periplasmic protein RseB, all of which have similar unclosed beta-barrel structures that resemble a baseball glove-like scaffold consisting of an 11-stranded antiparallel sheet. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts outer membrane (OM)-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. It is proposed that the LolA/LolB complex forms a tunnel-like structure, where the hydrophobic insides of LolA and LolB are connected, which enables lipoproteins to transfer from LolA to LolB. RseB exerts a crucial role in modulating the stability of RseA, the transmembrane anti-sigma-factor that is degraded during sigma-E-dependent transcription caused by bacterial envelope stress. Its structural similarity to LolA and LolB suggests that RseA may act as a sensor of periplasmic stress with a dual functionality, detecting mislocalized lipoproteins as well as propagating the signal to induce the sigma-E-response.	7.76929e-69
NZ_CP007451.1|WP_051567956.1|4011966_4014168_+|hypothetical-protein	gnl|CDD|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	8.03355e-27
NZ_CP007451.1|WP_038561190.1|4030075_4030558_+|PaaI-family-thioesterase	gnl|CDD|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	3.9953e-24
NZ_CP007451.1|WP_038561187.1|4029071_4029890_+|prohibitin-family-protein	gnl|CDD|259799	cd03401, SPFH_prohibitin, Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model characterizes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of the SPFH (band 7) domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. These microdomains, in addition to being stable scaffolds, may also be dynamic units with their own regulatory functions. Prohibitin is a mitochondrial inner-membrane protein which may act as a chaperone for the stabilization of mitochondrial proteins. Human prohibitin forms a hetero-oligomeric complex with Bap-37 (prohibitin 2, an SPFH domain carrying homolog). This complex may protect non-assembled membrane proteins against proteolysis by the m-AAA protease. Prohibitin and Bap-37 yeast homologs have been implicated in yeast longevity and in the maintenance of mitochondrial morphology.	6.99733e-62
NZ_CP007451.1|WP_038561182.1|4024935_4025472_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.54379e-08
NZ_CP007451.1|WP_038561147.1|4016153_4017044_+|type-II-CRISPR-associated-endonuclease-Cas1	gnl|CDD|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	1.45991e-102
NZ_CP007451.1|WP_157470842.1|4010176_4011106_+|hypothetical-protein	gnl|CDD|187774	cd09643, Csn1, CRISPR/Cas system-associated protein Cas9. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II.	1.25762e-21
NZ_CP007451.1|WP_038561153.1|4018014_4018971_-|threonylcarbamoyl-AMP-synthase	gnl|CDD|223088	COG0009, SUA5, Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis].	4.35724e-73
NZ_CP007451.1|WP_038561162.1|4021707_4022259_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	9.84428e-31
NZ_CP007451.1|WP_038561179.1|4023247_4024822_-|peptide-chain-release-factor-3	gnl|CDD|179105	PRK00741, prfC, peptide chain release factor 3; Provisional.	0
NZ_CP007451.1|WP_038561150.1|4017107_4017446_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	4.62872e-26
NZ_CP007451.1|WP_038561176.1|4022532_4023105_-|DUF2179-domain-containing-protein	gnl|CDD|235234	PRK04164, PRK04164, hypothetical protein; Provisional.	1.63978e-68
NZ_CP007451.1|WP_038561185.1|4027793_4028906_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein	gnl|CDD|336781	pfam07722, Peptidase_C26, Peptidase C26. These peptidases have gamma-glutamyl hydrolase activity; that is they catalyze the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to pfam00117, but contain extensions in four loops and at the C-terminus.	4.24641e-29
NZ_CP007451.1|WP_038561156.1|4019140_4019614_-|AIR-carboxylase-family-protein	gnl|CDD|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	1.45582e-52
NZ_CP007451.1|WP_038561159.1|4019582_4021544_-|DUF4914-family-protein	gnl|CDD|379810	pfam16260, DUF4914, Domain of unknown function (DUF4914). This family consists of uncharacterized proteins around 630 residues in length and is mainly found in various Thermotoga, Thermoanaerobacter and Carboxydibrachium species. The function of this family is unknown.	0

Protein sequences

>NZ_CP007451.1|WP_038561150.1|4017107_4017446_+|CRISPR-associated-endonuclease-Cas2
MQQTRLNAYHIMWLFVFFDLPVTTKKERRLATRFRKDLMKDGFSMMQFSVYNRHCASKESAEVHIKRIKSFIPEHGQVSILTVTDKQYGNIVNVWGNKSSPLPEGPKQLEMF
>NZ_CP007451.1|WP_038561147.1|4016153_4017044_+|type-II-CRISPR-associated-endonuclease-Cas1
MLKRTLFISNPYYLSLKNKQLQVSERGGMLLKSAPVEDIGFLVLDHPQISFSMKLVEELSEYNVATVFCNSKHMPSSMLLPLDAHHIQSELFRAQIAASEPLKKNLWKQTIEAKVKNQAALLDKLGKKSLQLKNIAKTIKSGDSDNREGFAARIYWTALLGKEFIRDRYGAPPNNFLNYGYILLRSAVARSLAGSGLLATLGIHHRNRYNAFCLADDIMEPYRPYVDEIACDLDEKYPGTFALEKEHKAELLQLMTADVKIGDNKRPLMVALSQTTASLARCFAGEQRKIIYPVFG
>NZ_CP007451.1|WP_038561144.1|4015477_4016101_+|hypothetical-protein
MKTILLEYGNFYHIYNRGINGCNLFRENENYEYFLHLYDKYISPVAETFAWVLMRNHFHFLIRIKTVKELNLQGFQNLEGLKGTNRNGVNQQFANLFNAYTKAINKRYHRTGSLFEHPFRRIKVESDAHLKYLVYYIHHNPIHHGFCDHYLDYPWSSYLTIVSPKATKLSRAEVLKWFRDKSNFEKFHLQEEIRKFDELNIRLPGDL
>NZ_CP007451.1|WP_038561141.1|4014757_4015414_+|hypothetical-protein
MNASQMNVDEILFQSGLRINNSLSDPLILNAVSLMGYNQEKLLEGQNLLDEATTLVETQKREYGEVDAAQQVFDNQRTNAHKVYMAVLAISKIAFKGDVQAISTLDLTGRRASTFSGWLNQTRSFYRAILANEAWKTELAKYGQTEAMLTGELAMIDAVATASENKKKEMGDAQNATQERDEKMEELAEWVTDYEVIARIALADKPQLLEKLGIVVKG
>NZ_CP007451.1|WP_139177988.1|4014360_4014561_+|hypothetical-protein
MEKTSAKRHLPRRNTKNRRGMAHYQRETEKTTEEWKKPLRNGKNQREMQGNAVVLHSAPVNCISRW
>NZ_CP007451.1|WP_051567956.1|4011966_4014168_+|hypothetical-protein
MQKKLYHPSAIETYKPAKRGKDGRLYLGSPITSSVRNPMAMRALHQLRLVINELIKNGLIDTNTKINVEMSRGLLNANERTGLKRWQDDREKKRKEYVDRIKEHFSPDYQPSEDEVLKYQLWEEQRRICLYTGKPISIEDFLGADPKFDIEHTIPRSQSYDNSQENKTLCENEFNRKVKRNRIPYELTNHAEIIVRIEHWKEEIEKLEKEIQKAVRQAKGAVDKDQKDKAIQKRHQLSYERNYWQNKYKRFTMEEVPEGFKNSQMVDIGIITKYSRLYLKTVFSKVYTVKGNTVADFRKMWGLQDIYTKKARVNHVHHCIDAVTIACMDKSNYETLAKFYHDWEELYVAGVDQLPPVNKPWPTFTEDVKGVEKEILVSHHTPDVLPKQSKKKLRKRGKIQYNKNGEPIYQQGDSVRGSLHKETFYGAIEREILNKKGETEKQIKYVVRKPLDGLEDSAIKNIVDDRVREIVSHARKEEKEIQKQIDALLKQRRKAEENEEAEIDNKIAELKQQIVELYSLPNKNGAPVPIKKVRVYQTPKGILEIKKHRDCIKKHKANYLTETDDNYIMGIYEYSQNGKIKRKFKAYNNFTASNYLRSDIKKSLSPQGIGAISAMLPNNFINEKGIELKLKAALKIGTLVIMHMPDENLNDLTNWDDLQKRLYKVYGFRGDDGRIKLRFHNEARPDKEQEKPSSSFSLDIIHSKLIISLGNFHALIEGIDFKIDPLGNIKRIN
>NZ_CP007451.1|WP_051567955.1|4011224_4012001_+|hypothetical-protein
MKTTVSGCPVSARFKDLFGADFIDDDFSFVKDSNNRTPKLITDAWHVLYTFDSDKKLKEFALNRLNFTDEQCTTFLKIRLKQDFASLSLKAINKILPYLREGLIYSHAVFLANMEETVPVHIWKNEENRKVIRTAIKEIIENHSDNTTIVNMVNGFITNARRENEVWSEEAKQLYFNDLDRKIKTTFGAKRFENFSEYKKTNLINTAQQLITEFMPKNLGKGEHVKVDRLDEAVLSFLADNFGKENLNAKKVISSLGN
>NZ_CP007451.1|WP_157470842.1|4010176_4011106_+|hypothetical-protein
MAKILGLDLGTNSVGWAVVEKQDGEFSLLDKGVRIFQEGVKIEKGIESSKAAERTEHRSARRLKFRRKLRKVKTLKMLSEYGYCPPLTNEELDLWRYKKIYPQNVSFRNWWHTDEKSEKHPYFFRNLAITQQLDLTNEEDRHKLGRAFYHMAQRRGFLSNRLESTPENETGKVIGSIKELQKKKGDRTLGQYFYEDCYLKGEKIRDQYTHREDDYLDEFKRICAFQHIPEEIQQKLHRAIFYQRPLKSQKGLIGKCVFEPNKPRCAVSRPEFEEYRMLCFINNIKIKTPDDEKLRPLNTEERKNNPTIL
>NZ_CP007451.1|WP_038561135.1|4008081_4009854_+|hypothetical-protein
MKIFEGHSFHIPVLGVGFSMDTPVNVAPFGISSVISLVDDSLMETIREFYCKKFDLPFTAISKKVDDHRAKRITSYLNTMEEVVTQKVESLKASLLNVGGELEKYYDMLPEASELKAKFNNLGFKKSVSEELKKWVNEKLPVGSIDVNIMTKLDQANKKDGEELPIEYNDAHAALRGFANSKLSSSLVLSAGMSPRLYSYIENFKDFFPDITGSMKKKIILKVSDFRSALVQGKMLAAKGLWVSEYRIESGVNCGGHAFPTNGVLLGPILEEFRQNRQKLFDTCVEVYKTALHKKEISQPAEDPEMKITAQGGVGNAEEHNLLLEHYNMDSVGWGSPFMLVPEVVSIDNETMNLLADGKEKDYYYSGLSPLGVPFNSIKGASMSNLRLAMAAEGNAGMPCTKGFLRFNTEFTEQPVCTASRKYQSKKLQELETMNLPEAEYKKAYDKIIERECLCIGLGISMLQSKGIAVKENEKVTVCPGPNLAYFSKISSLKEMVDHIYGRINLLDKGYRPHMFLKELSMYLDIFKERMEAFQKNADDVKEKRNLVKFKSNLMDGIEYYKNFFGEKKKEVVQELEKLIQNYSVLNVEL
>NZ_CP007451.1|WP_038561132.1|4006910_4007654_-|outer-membrane-lipoprotein-sorting-protein
MKRIVLTIATVLLALAVFAQDMTAIIKQADEKFRGESSRSEITMIIERPGWSRTVSMKNWTLGNDYSLIYITAPAKEKGQVFLKRDKEMWNWVPNIERMIKIPPSMMMQSWMGSDFTNDDLVKESQMAKDYSNKLLAEEEVDGYSCYKIELIPHEDAPVVWGKVMMWISKKELHWLKAEFYDEDGYLVNTEILTNIKMMDDREMPTRLEMIPADEEGNKTVMIFDAIEFDVDLKESFFSQQNMKRIR
>NZ_CP007451.1|WP_038561153.1|4018014_4018971_-|threonylcarbamoyl-AMP-synthase
MSSISNDIKLAAQLIGNGELVAFPTETVYGLGADAFNAEAVAKIFATKERPTFNPLIVHIRDISELEKLFVEIDDALLKLAEHFWPGPLTIVAKKQQAVPDIVSAGLDTVAVRMPANQTARELLKLSGKCIAAPSANRFGMLSPTTPEHVQKQLPELKCILNGELPKVGIESTVIELCQGEFKILRPGFITEQDLMKVLPQSKAKEANSPIKSPGLLKSHYSPRKPMYLLGNEPEYSANKKYGFLAFSEVKNPDKYHQIERLSTNADLGEAAANFFEALHRLEDSDVDLIIAEPVPETGIGIAIMDRLNKAVYQYRGK
>NZ_CP007451.1|WP_038561156.1|4019140_4019614_-|AIR-carboxylase-family-protein
MSKVVIIMGSKADLDWANKIVDALNGFKIDSECFIASAHKVPLECYNIIKEQEMHNPVFITIAGMSNALSGFSDAQTNCPVIACPPVGDSFAGADIYSSLRMPSGVAPMVILNPKNAALAAAKIIGLNNDEVRTEVSKFQEAQRQKLIEDNSSIRSN
>NZ_CP007451.1|WP_038561159.1|4019582_4021544_-|DUF4914-family-protein
MKIAFPDFKTKLDKKGVKLPANIEKVLSACQSFTCYNTTEELADAATCGKENNEFAVSYDIEGKGTFTEAIVHRVQNGISVNYTEAYMRRRDPGTMVIGDDKPTGKQRFSEKYNYPFSDIQKETFDWLKENDLAVFFYFAGRQGIGSLGIAIAPANAGFFAMGLSMLQEIVAIDELAENSELKSVIYVAPVFRHTHFDGKQVVVHNRLDDIHELYSYNLYPGPSAKKGLYGVLLTQGEKEEWVTAHCSAVQSISPYDIVTTFMHEGASGGGKSELHQHIVRETDGRVLLGKNSVTGETRYITIPRTCNFLPIADDMAFCHPSFQKKNGKLGIMDAENAWFVRVDSVNQYGDDPVLEKATIHPKKPLLFLNIDTKPESTALIWNHIEDEPGKPCPNPRVVLPRESVENTINGSVSVDVRSFGIRTPKCSKEDPTYGIVGLFHVLPPALAWLWRLVAPRGHKNPSIVGTGAMESEGVGSYWPFATGDRIIHANLLLKQIIETPRTIFSLVPNQNIGVWEVGFKPQLLMREYLTRRGGAKLKDDQIQAARCPLLGYELNYLTIESSKIPSRFLKVYNQVEVGTEGYDAGAEVLQEFFNRELKKFMHKDLFHTGRKIIDACLSNASIEEYNQIIPMDYEYSFNNIEDYEQSSYNNGL
>NZ_CP007451.1|WP_038561162.1|4021707_4022259_-|helix-turn-helix-transcriptional-regulator
MKRLGERIRRKRDALHLKLNDLSKKVGISSSALSQIEKAKAFPSILTLKNIADSLNTTVGELIGENETLLNQPLIKNDEKKFVKKNESGTKLYLLSHHDPHKQMETYELEFAPGSDSKGIMTAHPGQEFCHVTEGKLAILLDGKPYILETGDSFYFNSNITHNAQNIIEGTTRVVWVVTPPNI
>NZ_CP007451.1|WP_038561176.1|4022532_4023105_-|DUF2179-domain-containing-protein
METSFYDSAFFTYGLLPGLIFFSRVMDVTIGTIRIVMVSKGHKLWAPLLGFFEILIWLIAISKIFQNLDNWFCYIAYAAGFACGNYVGLLIEEKLAVGIVKLQIITRKEASKLIENLTAAGYGITHHNAQGANERVSIIHSIIKRSEIKKVETIVKTTNPKAFYSVEDVKFVNEGVFPVHPARFRIRKGK
>NZ_CP007451.1|WP_038561179.1|4023247_4024822_-|peptide-chain-release-factor-3
MSFLEEIQRRRTFGIVSHPDAGKTTLTEKLLLFGGAIRVAGAVKSNKIKKGATSDFMEIERQRGISVATSVMGFEYNGYKVNILDTPGHQDFQEDTFRTLTAVDSVIIVIDAAKGVEPQTEKLMNVCRMRKTPVIVFVNKMDRPAGDPFTLMDEIEDQLKIKVRPLSWPINNGPDFKGVYNIFNRSLKLFTPDIQEIEERIKFEDISDPTLEDHIGEDADVLREELELVEGIYPEFNNEDYLSGELAPVFFGSALYNFGVQELLDSFVKIAPTPQPSETEERVVKPEEKGFTGFVFKIHANIDPNHRSRIAFVKICSGKFERNKMYKNVRLGKSFRISSPTAFMASQKEIVEEAFPGDIIGVPDTGNYIIGDTVTDGEDIHFKGLPSFSPEMFRFVENADPMKSKQLAKGVDQLMDEGVAQLFTSAFNGRKIIGTVGQLQFEVIQYRLEHEYGAKCRFEPLSMHKACWIECNDEKVLTEFKKRKHQKMAKDKLGRDVFMADSAFILQMAQDEFKDIKFHFTSEF
>NZ_CP007451.1|WP_038561182.1|4024935_4025472_+|GNAT-family-N-acetyltransferase
MIFINVDELKFNAYKNDLVNLYINTFSAGKSFQYHSEEETAAYLQAIFDVGYGIFAMEEHEVAGVILVTPLSFDRLLPEEIAQNFDVKRSVYVAEMMVEKSKQRQGIGKRLLTLFLKETDRTQFDHAFIRVWEENEAAVDLYKKMGFEVYATMVQPKMLADKSGTFDFEKIYLHQRLS
>NZ_CP007451.1|WP_038561185.1|4027793_4028906_-|gamma-glutamyl-gamma-aminobutyrate-hydrolase-family-protein
MKKLLLLLFAFLLLGNAFAQHFFDTDFNPRKKYIILCDPTVNHIKTIKYLADNNILKLNKNKVKFVAVYYQGQKTDYTETQNYINENKLENFYLHEITGELNETNLYRENAVTHQLKKVFDNSIGVIFFGGADIPPTIYGEENTKSGVYTPARHYYEATFMFHLLGGYQNESFKPFLAERPDYVVTGFCLGMQTMNVATGGTLIQDIPAEIYKAETPEETVAIGRANMHRNYWQLIGEDSLFMGINLHTIQFTDNPFFGETIKTSKKATPRIYSSHHQAIEKLGKGLEVTCLSPDGKIIEGVTHSTYPHVFAVQFHPEVSALYENMELKIFHPDDEPATYHDILGKSSVKFHKNYWKHISKSFKDVKKPK
>NZ_CP007451.1|WP_038561187.1|4029071_4029890_+|prohibitin-family-protein
MKFNFKSSYLVLGAVILIVLLLFGGRMFKILKPGEKAVIFKPYTTGLDKDNIFGEGFHVIAPWNELEIYNVREQQREETMDVLDKNGLSVNVDVTVRFNPSYSKIGFLHEQFGVNFVNVLVIPEVRSSVRQVAGRYTAEEIYSTKRAEVEQSIITETKKALSANFIDMRALLIRSINLPAQIKGAIENKLQQEQEALAYEFRLKREESEAERRRIEAEGIANYNRIINASLTDNILTQRGIEATTSLAESPNSKVVVIGSGKDGLPIILGNN
>NZ_CP007451.1|WP_038561190.1|4030075_4030558_+|PaaI-family-thioesterase
MKKIKNPWKDPQNIGEYNCFACSPYNSAGLQLEFWEDGEEIITKWKPERSYEGWIGVLHGGIQATLLDEIGGWVVMLKLKTAGVTTDMQVSYLKAVKVSKGEVTIKGKLVSHEGRTAKISASLYDGAGEECAKAELSYFVFPEKIAKARYQYPGIEAFYD

Crispr_ID: NZ_CP007451_9

• CRISPR_ID: NZ_CP007451_9
• CRISPR_location: 4997634-4997731
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP007451_9

Consensus_repeat	Method
CCGCCGCTGCCGCGCGAATCCCTTCGCGTGGT	CRISPRCasFinder

spacers of NZ_CP007451_9

>9.1|4997666|34|NZ_CP007451|CRISPRCasFinder
GATTGAACAAACAACATCCTTTCGTGTGGTTTAG

CRISPR arrays and Neighbor proteins around NZ_CP007451_9

CRISPR arrays

The CRISPR arrays of NZ_CP007451_9

>merge|NZ_CP007451|9|4997634-4997731|CRISPRCasFinder
CCGCCGCTGCCGCGCGAATCCCTTCGCGTGGTGATTGAACAAACAACATCCTTTCGTGTGGTTTAGCCGCCGCTGCCGCGCGAATCCCTTCGCGTGGT

>NZ_CP007451|9|7|4997634-4997731|CRISPRCasFinder
CCGCCGCTGCCGCGCGAATCCCTTCGCGTGGT	GATTGAACAAACAACATCCTTTCGTGTGGTTTAG
CCGCCGCTGCCGCGCGAATCCCTTCGCGTGGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007451.1|WP_038563087.1|4997043_4997484_+|WxcM-like-domain-containing-protein	unknown	unknown	gnl|CDD|380426
NZ_CP007451.1|WP_038565661.1|4992403_4993507_+|glycosyltransferase-family-4-protein	unknown	unknown	gnl|CDD|340837
NZ_CP007451.1|WP_081804926.1|4991868_4992363_+|glycosyltransferase	unknown	unknown	gnl|CDD|340831
NZ_CP007451.1|WP_038563081.1|4994665_4995805_+|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|187571
NZ_CP007451.1|WP_038563105.1|5001734_5002316_+|dTDP-4-dehydrorhamnose-3,5-epimerase	unknown	unknown	gnl|CDD|376414
NZ_CP007451.1|WP_038563096.1|4998941_4999997_+|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl|CDD|187557
NZ_CP007451.1|WP_038563101.1|5001182_5001545_+|endonuclease-domain-containing-protein	unknown	unknown	gnl|CDD|238509
NZ_CP007451.1|WP_168136456.1|4987214_4987871_+|EpsG-family-protein	unknown	unknown	unknown
NZ_CP007451.1|WP_038563078.1|4993530_4994568_+|polysaccharide-biosynthesis-protein	unknown	unknown	gnl|CDD|275003
NZ_CP007451.1|WP_038563117.1|5004728_5005100_+|DUF86-domain-containing-protein	unknown	unknown	gnl|CDD|225236
NZ_CP007451.1|WP_038563098.1|5000209_5001082_+|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl|CDD|130274
NZ_CP007451.1|WP_038563067.1|4990089_4991169_+|CapA-family-protein	unknown	unknown	gnl|CDD|277327
NZ_CP007451.1|WP_038563084.1|4995906_4997037_+|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	unknown	unknown	gnl|CDD|340819
NZ_CP007451.1|WP_038565665.1|5004442_5004739_+|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|224583
NZ_CP007451.1|WP_038563120.1|5005616_5005997_-|HU-family-DNA-binding-protein	unknown	unknown	gnl|CDD|375718
NZ_CP007451.1|WP_038563093.1|4998640_4998922_+|GIY-YIG-nuclease-family-protein	unknown	unknown	gnl|CDD|198396
NZ_CP007451.1|WP_038563090.1|4997795_4998353_+|transposase	unknown	unknown	gnl|CDD|224854
NZ_CP007451.1|WP_038563110.1|5002624_5003809_+|IS4-family-transposase	unknown	unknown	gnl|CDD|376573
NZ_CP007451.1|WP_051568100.1|4987899_4988886_+|hypothetical-protein	unknown	unknown	gnl|CDD|133037
NZ_CP007451.1|WP_081804925.1|4991171_4991546_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP007451.1|WP_038563087.1|4997043_4997484_+|WxcM-like-domain-containing-protein	gnl|CDD|380426	cd20292, cupin_QdtA-like, sugar 3,4-ketoisomerase QdtA and related proteins, cupin domain. This family includes cupin domains of several bacterial proteins homologous to sugar 3,4-ketoisomerases. Thermoanaerobacterium thermosaccharolyticum QdtA catalyzes a key step in the biosynthesis of these sugars, the conversion of thymidine diphosphate (dTDP)-4-keto-6-deoxyglucose to dTDP-3-keto-6-deoxyglucose. In Aneurinibacillus thermoaerophilus, TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (also known as FdtA) is involved in the biosynthesis of dTDP-Fucp3NAc (3-acetamido-3,6-dideoxy-alpha-d-galactose), which is part of the repeating units of the glycan chain in the S-layer. Shewanella denitrificans bifunctional ketoisomerase/N-acetyltransferase (also known as FdtD) is involved in the third and fifth steps in the production of 3-acetamido-3,6-dideoxy-alpha-d-galactose or Fuc3NAc; the C-terminal cupin domain harbors the active site responsible for the isomerization reaction. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.16462e-08
NZ_CP007451.1|WP_038565661.1|4992403_4993507_+|glycosyltransferase-family-4-protein	gnl|CDD|340837	cd03808, GT4_CapM-like, capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.	1.22814e-119
NZ_CP007451.1|WP_081804926.1|4991868_4992363_+|glycosyltransferase	gnl|CDD|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.34333e-11
NZ_CP007451.1|WP_038563081.1|4994665_4995805_+|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|187571	cd05261, CAPF_like_SDR_e, capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs. This subgroup of extended SDRs, includes some members which have been identified as capsular polysaccharide assembling proteins, such as Staphylococcus aureus Cap5F which is involved in the biosynthesis of N-acetyl-l-fucosamine, a constituent of surface polysaccharide structures of S. aureus. This subgroup has the characteristic active site tetrad and NAD-binding motif of extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	7.23548e-70
NZ_CP007451.1|WP_038563105.1|5001734_5002316_+|dTDP-4-dehydrorhamnose-3,5-epimerase	gnl|CDD|376414	pfam00908, dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. This family catalyze the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	5.61994e-111
NZ_CP007451.1|WP_038563096.1|4998941_4999997_+|dTDP-glucose-4,6-dehydratase	gnl|CDD|187557	cd05246, dTDP_GD_SDR_e, dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs. This subgroup contains dTDP-D-glucose 4,6-dehydratase and related proteins, members of the extended-SDR family, with the characteristic Rossmann fold core region, active site tetrad and NAD(P)-binding motif. dTDP-D-glucose 4,6-dehydratase is closely related to other sugar epimerases of the SDR family. dTDP-D-dlucose 4,6,-dehydratase catalyzes the second of four steps in the dTDP-L-rhamnose pathway (the dehydration of dTDP-D-glucose to dTDP-4-keto-6-deoxy-D-glucose) in the synthesis of L-rhamnose, a cell wall component of some pathogenic bacteria. In many gram negative bacteria, L-rhamnose is an important constituent of lipopoylsaccharide O-antigen. The larger N-terminal portion of dTDP-D-Glucose 4,6-dehydratase forms a Rossmann fold NAD-binding domain, while the C-terminus binds the sugar substrate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NZ_CP007451.1|WP_038563101.1|5001182_5001545_+|endonuclease-domain-containing-protein	gnl|CDD|238509	cd01038, Endonuclease_DUF559, Domain of unknown function, appears to be related to a diverse group of endonucleases.	2.94352e-33
NZ_CP007451.1|WP_038563078.1|4993530_4994568_+|polysaccharide-biosynthesis-protein	gnl|CDD|275003	TIGR04130, L-fucosamine_synthetase, UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase. The FnlA enzyme is the first step in the biosynthesis of UDP-FucNAc from UDP-GlcNAc in E. coli (along with FnlB and FnlC). The proteins identified by this model include FnlA homologs in the O-antigen clusters of O4, O25, O26, O29 (Shigella D11), O118, O145 and O172 serotype strains, all of which produce O-antigens containing FucNAc (or the further modified FucNAm). A homolog from Pseudomonas aerugiosa serotype O11, WbjB, also involved in the biosynthesis of UDP-FucNAc has been characterized and is now believed to carry out both the initial 4,6-dehydratase reaction and the subsequent epimerization of the resulting methyl group at C-5. A phylogenetic tree of related sequences shows a distinct clade of enzymes involved in the biosynthesis of UDP-QuiNAc (Qui=qinovosamine). This clade appears to be descendant from the common ancestor of the Pseudomonas and E. coli fucose-biosynthesis enzymes. It has been hypothesized that the first step in the biosynthesis of these two compounds may be the same, and thus that these enzymes all have the same function. At present, lacking sufficient confirmation of this, the current model trusted cutoff only covers the tree segment surrounding the E. coli genes. The clades containing the Pseudomonas and QuiNAc biosynthesis enzymes score above the noise cutoff. Immediately below the noise cutoff are enzymes involved in the biosynthesis of UDP-RhaNAc (Rha=rhamnose), which again may or may not produce the same product.	0
NZ_CP007451.1|WP_038563117.1|5004728_5005100_+|DUF86-domain-containing-protein	gnl|CDD|225236	COG2361, COG2361, Uncharacterized conserved protein [Function unknown].	5.16771e-17
NZ_CP007451.1|WP_038563098.1|5000209_5001082_+|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl|CDD|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	1.65948e-179
NZ_CP007451.1|WP_038563067.1|4990089_4991169_+|CapA-family-protein	gnl|CDD|277327	cd07381, MPP_CapA, CapA and related proteins, metallophosphatase domain. CapA is one of three membrane-associated enzymes in Bacillus anthracis that is required for synthesis of gamma-polyglutamic acid (PGA), a major component of the bacterial capsule. The YwtB and PgsA proteins of Bacillus subtilis are closely related to CapA and are also included in this alignment model. CapA belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	3.04543e-58
NZ_CP007451.1|WP_038563084.1|4995906_4997037_+|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	gnl|CDD|340819	cd03786, GTB_UDP-GlcNAc_2-Epimerase, UDP-N-acetylglucosamine 2-epimerase and similar proteins. Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family (EC 5.1.3.14) are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues (UDP-ManNAc) for use in the biosynthesis of a variety of cell surface polysaccharides; The mammalian enzyme is bifunctional, catalyzing both the inversion of stereochemistry at C-2 and the hydrolysis of the UDP-sugar linkage to generate free ManNAc. It also catalyzes the phosphorylation of ManNAc to generate ManNAc 6-phosphate, a precursor to salic acids. In mammals, sialic acids are found at the termini of oligosaccharides in a large variety of cell surface glycoconjugates and are key mediators of cell-cell recognition events. Mutations in human members of this family have been associated with Sialuria, a rare disease caused by the disorders of sialic acid metabolism. This family belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	2.73814e-147
NZ_CP007451.1|WP_038563120.1|5005616_5005997_-|HU-family-DNA-binding-protein	gnl|CDD|375718	pfam18291, HU-HIG, HU domain fused to wHTH, Ig, or Glycine-rich motif. Rapidly-diverging family of HU domains predominantly observed in the bacteroidetes lineage with a predicted role in recognition and possible interception of the DNA of parasitic elements, a counter-conflict strategy preventing incorporation of these elements into the host genome.	2.47081e-28
NZ_CP007451.1|WP_038563093.1|4998640_4998922_+|GIY-YIG-nuclease-family-protein	gnl|CDD|198396	cd10449, GIY-YIG_SLX1_like, Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs. Structure-specific endonuclease subunit SLX1 is a highly conserved protein from yeast to human, with an N-terminal GIY-YIG endonuclease domain and a C-terminal PHD-type zinc finger postulated to mediate protein-protein or protein-DNA interaction. SLX1 forms active heterodimeric complexes with its SLX4 partner, which has additional roles in the DNA damage response that are distinct from the function of the heterodimeric SLX1-SLX4 nuclease. In yeast, the SLX1-SLX4 complex functions as a 5' flap endonuclease that maintains ribosomal DNA copy number, where SLX1 and SLX4 are shown to be catalytic and regulatory subunits, respectively. This endonuclease introduces single-strand cuts in duplex DNA on the 3' side of junctions with single-strand DNA. In addition to 5' flap endonuclease activity, human SLX1-SLX4 complex has been identified as a Holliday junction resolvase that promotes symmetrical cleavage of static and migrating Holliday junctions. SLX1 also associates with MUS81, EME1, C20orf94, PLK1, and ERCC1. Some eukaryotic SLX1 homologs lack the zinc finger domain, but possess intrinsically unstructured extensions of unknown function. These unstructured segments might be involved in interactions with other proteins.	1.54505e-20
NZ_CP007451.1|WP_038563090.1|4997795_4998353_+|transposase	gnl|CDD|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	7.72717e-05
NZ_CP007451.1|WP_038563110.1|5002624_5003809_+|IS4-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.03494e-07
NZ_CP007451.1|WP_051568100.1|4987899_4988886_+|hypothetical-protein	gnl|CDD|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	8.11815e-40
NZ_CP007451.1|WP_038565665.1|5004442_5004739_+|nucleotidyltransferase-domain-containing-protein	gnl|CDD|224583	COG1669, COG1669, Predicted nucleotidyltransferases [General function prediction only].	4.03719e-15

Protein sequences

>NZ_CP007451.1|WP_038563087.1|4997043_4997484_+|WxcM-like-domain-containing-protein
MNNKQPLLIRGGLYSDERGELSYVNDFDLTNVKRFYVIKHPDKRVVRAWQGHQQEHKYFKCLKGSFVVAWVEIDNFKNPSVKLNAQYEILKASENNVLSVPPGNANGLKALEPGSQIIVFSDYALNESLDDKIRFEKDLWLDWSQF
>NZ_CP007451.1|WP_038563084.1|4995906_4997037_+|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)
MKKLKVLTVVGTRPEIIRLSEVLKKLDQSEAIQHILVHTGQNYDYELNEVFFNDLGLRKPDHFLNAAGGNATTTAGKILINIDPVLEEEKPDAFLVLGDTNSCLCAIAAKKRKVPIFHMEAGNRCFDQRVPEETNRRIVDHISDINLTYSSIAREYLLREGLPADRVIKTGSPMFEVLQANRKQIDESDVLSKLKLEKGNYFVVSAHREENINSTNFDKLVLTLNRVAEKYQFPIIVSTHPRTRNKINEKGTEFNSLIQLMKPLGFHDYNHLQKNAFAVLSDSGTISEESSIMNFRALNIREAHERPEAMEEASVMMVGLNPERILQGLVQLQYQHVDEERNFRPVYDYSMPNVSDKVVRIILAYTDYINQNVWRK
>NZ_CP007451.1|WP_038563081.1|4994665_4995805_+|NAD-dependent-epimerase/dehydratase-family-protein
MSKIKIGITGQAGFVGTHLYNTLGLYPDKYERIPFEDDFFKSEESLQQFVKQCDAIVHLAAMNRHKDPEVIYQTNIKLVNQLIEACEATQSAPHILFSSSTQEERDNLYGKSKQEGRELLEKWAENNNARFTGLVIPNVFGPFGQPYYNSVVATFCHQLTHNENPTIQTDGEINLIYVAELVAEITGQIERPVTDAQSPVTKYFVPNTSQIKVSALLDKLSEFKKNYFEKGIIPNLDEPFERNLFNTFLCYIDHKNFFPFKLKLNTDDRGSFIETVKLNSGGQVSFSTTVPGITRGNHFHTRKAERFAVIKGKAKIELRKIGTGEVYTFELDGSQPSFVDMPIWFTHNITNIGEEELYTIFWINEHYNPEDGDTYFEEV
>NZ_CP007451.1|WP_038563078.1|4993530_4994568_+|polysaccharide-biosynthesis-protein
MFKNKTLLITGGTGSFGNAVLNRFLDTDIKEIRIFSRDEKKQDDMRHRLNNPKVKFYIGDVRDKRSVDGAMMGVDYIFHAAALKQVPSCEFFPTQAVRTNVFGTENVLDSAIQHVVKNVVVLSTDKAAYPINAMGISKAMMEKVAIAKGRALGKDAATTICCTRYGNVMASRGSVIPLWVKQIKEGNDITITDPNMTRFMMTLEDAVDLVLYAFQNGENGDLFVQKAPAATLDVLAEALKGLYKKDTTVRVIGTRHGEKLYETLVTREEMAKHVDRGNYFRIPCDDRDLNYDKYFEEGEEKISKLEDYHSHNTRRLDIKGMQELLLKLPLVRKDVLGEEGFQYPD
>NZ_CP007451.1|WP_038565661.1|4992403_4993507_+|glycosyltransferase-family-4-protein
MRIVISINTAWNIYNFRLGLIKVLLADGHEVYAVSPQDKYVKKLETHGIKHFKVNINHKGTNPFEDIKLVKAYKRIFLKIQPDIILSYTIKPNIYGNLAAQKVGVPVINNVSGLGTLFIKNSFASIVGKFLYHYSFKNSNWVFFQNNTDKELFIQAKLVKGDKVSVLPGSGVNTQKFSIKRKSNSGKRFLFVGRLLKDKGIIEYLKASQNLSKKYPNVNFTMVGELGYANKTAITEIELKNWVKNKQIKYLGKQDDMVKVLAETDVMVLPSYREGLSKSLIEAAAMNLPIVTTDVPGCREVVEHGTNGFLCQVKNADDLQNKMETMINLSQEERLKMGEEGRRIAENKYSEEIVIKLYKDKINELIS
>NZ_CP007451.1|WP_081804926.1|4991868_4992363_+|glycosyltransferase
MDTLYKLKEHDFIFDVYGLTYDQYITVVDYQKDKLNELKDKVIFHGPIENRIARQKIAQSDYSILFRDINKMTKAGFPTKVVESISCGTPVITNNTSDLQNYIFEGENGFVVDLSKPDLHLHKMNEILKMDTMAINKMKQNCAKSELFSYQNFKDKTERFLQKI
>NZ_CP007451.1|WP_081804925.1|4991171_4991546_+|hypothetical-protein
MQKKILYVGNFSFPNGNASGARVLGNGYLFRELGYKTFFIGLDKQLNENSNLPETRNEFEGFAYYNLPYPKGVRGWIAYKQRYIEVAKLIKDLNIDIIILYGSPTISLFGSLLKSFAKKITLKY
>NZ_CP007451.1|WP_038563067.1|4990089_4991169_+|CapA-family-protein
MKIAFLGDIALIGKYDLTQNPNAKSALKDIAEVLKDYDFVIGNLESPLTDKESTMVCKSMHLRSPSININLLKYLNINIVSLANNHTYDFGRKGIEDTVKILTSNGIDYFGIDNKSIDINNAVIRGFVCYSTNAIGYNSTSKNKGVNTLDYKEVIKQVEEDKAAGKTSILSIHWGDEHTNYPRHEHIKFSHLLAKKNDIIISGHHPHVIQGVEKINNSLIAYSQGNFCFDDCEAISGTGMKLTQNDENRESFIFDVSIDENRIINYKTIGIKEINNQIKVASIDSKLTNLSNEIKNIKDPISYQNKRVSQFSDKDFREKKFGKKTFGWYVKRLNYYAIGAYLIGKINKYKYTKQFSKFL
>NZ_CP007451.1|WP_051568100.1|4987899_4988886_+|hypothetical-protein
MQQTNNTIYIAYSCDEAYIHHTGISLISLFENNKGINSIIIYFIEKGVRQESINQLQTICDKYKRKLEVIPFSSICNDLHPSDTGRHIETIYSKLFFSRISNIDKMLYIDSDTIINGSIHELWSIDLSNYCVAGVETYTVKSKERLNLLPEDNFINDGIVLLNLEKLRKNRYDLKFLDFINMFNGNPPLLSEGTINFVCKGSILSLHPKFNLMSGLISIPNTNYTKNKYLSNYYSDEIIDEAIKSPVIIHYLSAFYNRPWDKNCTHPLKNRYLFYKSLSPWRNIPLTNKKLTLRLRFIKYLQNMLPERFFLSLRYISILLKNKFNVRN
>NZ_CP007451.1|WP_168136456.1|4987214_4987871_+|EpsG-family-protein
MRYYVLVFVAFGFHYSAILLFILPLLKRIPINFFSILIIIVIGAFLNTFFLSFINSLSGNNGFFMSLENYGDYNYTIWGLVGIIVLYVLYPFIVMNASTNFLNIKNSLYPFLRFFILIGAFCSLFYIFFRFRNYFTPIFFVFLTEVVHSIFRNKKIKEFRKIISFLILFFFAFMHSYKYFSDTSEKVDSSRWYSLWYPYNSIFDKDTDPTRERLFNEL
>NZ_CP007451.1|WP_038563090.1|4997795_4998353_+|transposase
MSRNYKFHNPDGVYFVSFAVVNWLDVFIRNEYKNIILDSLSFCQRNKGMEIFAWCIMPSHVHLVFRSDKDEVKPEQLLGDFKRFTSNAIIKAIKENPRESRKEILLEHFQKAGALTSNVSKNQFWRHDNRPIELWSNKVIDEKINYIHQNPVEEGLVFRAEDYMYSSAIDYAGEKGLLKNIIVVK
>NZ_CP007451.1|WP_038563093.1|4998640_4998922_+|GIY-YIG-nuclease-family-protein
MKGFYYTYILYSEKDGQNYAGYTHDLNLRFELHCKGNVPSTKYRRPLKLIYFEACLSKEDALKREKYFKTHYGKMFLKNRLKSYFTGFQPETK
>NZ_CP007451.1|WP_038563096.1|4998941_4999997_+|dTDP-glucose-4,6-dehydratase
MKKKILITGGAGFIGSHVVRLFVNNYPNYEIVNLDKLTYAGNLANLADVEDKPNYRFIKGDIVDAAFIQELFETEQFDGVIHLAAESHVDRSIANPTEFVFTNVIGTVNLLNAAKHIWKDNREGKRFYHISTDEVYGSLGKEGFFTEETGYDPHSPYSASKASSDHFVRAYNDTFGLPTVISNCSNNYGSFQFPEKLIPLFINNIRNNKALPVYGKGENVRDWLWVVDHARAIDVIFHKGELGETYNIGGFNEWTNIDLIKVICKKMDKKLGREAGTSEKLITYVKDRAGHDLRYAIDATKIKNELGWEPSLQFEEGIEKTIDWYLANEEWMNNVTSGDYLKYYEAQYQER
>NZ_CP007451.1|WP_038563098.1|5000209_5001082_+|glucose-1-phosphate-thymidylyltransferase-RfbA
MKGIILAGGSGSRLHPITLGTSKQLLPVYDKPMIYYPLSVLMLAGIKDILIITTPDDQSNFMKLLGDGSQWGINLQYTIQPSPDGLAQAFILGKEFIGDDNVCLVLGDNIFYGHGFTSLLKNAVTAVEEEGKASVFGYYVNDPERYGVCTFDGAGNVTTIEEKPEQPKSNYAVVGLYFYTNSVVQVAETIQPSARGELEITTVNQEYLTRNELKVELMGRGYAWLDTGTHESLMEASSFIETIEKRTGLKVACLEEIAYQRGWITKEQLIAQGENLAKNQYGQYLLSLVK
>NZ_CP007451.1|WP_038563101.1|5001182_5001545_+|endonuclease-domain-containing-protein
MELHNRKFYKPIPKHLRNNSTAAEATLWQMLKKRQLNGYKFRRQHSIGNYIVDFFCYELILAIELDGEVHADLNSIARDSERDEQLNNLGVTVLHYENRWVYEYPEIIKQDIIDFGEKKS
>NZ_CP007451.1|WP_038563105.1|5001734_5002316_+|dTDP-4-dehydrorhamnose-3,5-epimerase
MQVINTTIPEVLIFEPKVFGDNRGYFMESFRQKVIEEHIGQVNFVQDNESFSQYGVLRGLHFQRPPHTQGKLVRVLQGEVLDVAVDIRLNSPTYGQHVPVRLSADNKRQLWIPRGFAHGFAVLSPTALFSYKCDNYYAPEFDGGLMWNDPAIGIDWQIPDKDIQLSEKDTQHPLIKDISDFEYAVFSRENVYR
>NZ_CP007451.1|WP_038563110.1|5002624_5003809_+|IS4-family-transposase
MTGKQSKISITELLSLLPDEELNKIARRTKVNYYVKVLDGKSIFCLILYALVECQRNSLRTMEDIFNSAQFKFLFNLDTTQTIRHSSISERLSVINIEFFQQAYELTYNYFSTYYSRLQREQVRLIRVDSSMVAEAANKLIEGMNVGCKKDGKKQIKFTVAFDGDLPCMTKIFTNRKCLSEDTTIPQVVFDYARKDKSAIFTFDRGVGKRETFCRLSQQGTSFVTRINPKAKYKLVRELENGNNRLVGSLELIKELEVQLPKNRKEHWVFPEETFRLTITRHPEDGTEYWFLTNLFEIGVEEVLQYYKKRWDIEVFFRFLKQELNFSHITSTNPNGIAVMMYMTMITAMMVLIYKKLNNIGYKTAVRRISLELNELIIKMIVKHCGGDPSLVFR
>NZ_CP007451.1|WP_038565665.1|5004442_5004739_+|nucleotidyltransferase-domain-containing-protein
MKTRQQYCKLLLDFKQNRGQAYGILKLGIFGSVARKEQHKNSDIDIYYEGAVLSLLQTAALKEELEKLLETSVDIVRFRKSMNKLLKKRIEKEGLYVG
>NZ_CP007451.1|WP_038563117.1|5004728_5005100_+|DUF86-domain-containing-protein
MWDKELVNDLIELIIENLDTVKDRTKDIYCADDFSSNEQGMILLDSTCMKLAAIGESIKSLDKISNKQLLSNYPEVPWKQVMGMRDIIVHHYFDIDAEVILKTIKEDVPFLIKTLRKIYKELE
>NZ_CP007451.1|WP_038563120.1|5005616_5005997_-|HU-family-DNA-binding-protein
MAKLKGIPKRNPQAPEEDPKFYASLVHEERVEIDALATKVSQRCSLRRSDVHGVLVALMDIIPEQLLNGDIVALGELGSFCAAVSSEGVDSVDDLSVTMVRGAKIQYRPTKELKKKLRMLDYTIAS

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP007451_2	2.3|1033111|18|NZ_CP007451|CRT	1033111-1033128	18	NZ_CP007451.1	1032988-1033005	0	1.0
NZ_CP007451_2	2.1|1033029|18|NZ_CP007451|CRT	1033029-1033046	18	NZ_CP007451.1	2253147-2253164	1	0.944

1. spacer 2.3|1033111|18|NZ_CP007451|CRT matches to position: 1032988-1033005, mismatch: 0, identity: 1.0

gttttgtggggaaaacaa	CRISPR spacer
gttttgtggggaaaacaa	Protospacer
******************

2. spacer 2.1|1033029|18|NZ_CP007451|CRT matches to position: 2253147-2253164, mismatch: 1, identity: 0.944

attttgcccgcaaaatgg	CRISPR spacer
attttgcccccaaaatgg	Protospacer
********* ********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	NZ_CP024285	Escherichia albertii strain 2014C-4356 plasmid unnamed3, complete sequence	46032-46072	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	NZ_CP024285	Escherichia albertii strain 2014C-4356 plasmid unnamed3, complete sequence	46039-46079	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	NZ_CP024285	Escherichia albertii strain 2014C-4356 plasmid unnamed3, complete sequence	46046-46086	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	NZ_CP024285	Escherichia albertii strain 2014C-4356 plasmid unnamed3, complete sequence	46053-46093	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	CP031286	Escherichia fergusonii strain 40A plasmid p80_40A, complete sequence	58682-58722	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	CP031286	Escherichia fergusonii strain 40A plasmid p80_40A, complete sequence	58689-58729	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	CP031286	Escherichia fergusonii strain 40A plasmid p80_40A, complete sequence	58696-58736	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	CP031283	Escherichia fergusonii strain 40A plasmid p150_40A, complete sequence	147871-147911	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	CP031283	Escherichia fergusonii strain 40A plasmid p150_40A, complete sequence	147878-147918	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	NZ_CP040808	Escherichia fergusonii strain EFCF056 plasmid pEF03, complete sequence	51018-51058	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	NZ_CP040808	Escherichia fergusonii strain EFCF056 plasmid pEF03, complete sequence	51025-51065	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	NZ_CP040808	Escherichia fergusonii strain EFCF056 plasmid pEF03, complete sequence	51032-51072	6	0.854
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	NZ_CP040808	Escherichia fergusonii strain EFCF056 plasmid pEF03, complete sequence	51039-51079	6	0.854
NZ_CP007451_8	8.4|4017899|30|NZ_CP007451|CRISPRCasFinder,CRT	4017899-4017928	30	NZ_CP023822	Escherichia coli strain 7/2 plasmid p7_2.2, complete sequence	37077-37106	6	0.8
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	NZ_CP024285	Escherichia albertii strain 2014C-4356 plasmid unnamed3, complete sequence	46025-46065	7	0.829
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	CP031286	Escherichia fergusonii strain 40A plasmid p80_40A, complete sequence	58675-58715	7	0.829
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	CP031283	Escherichia fergusonii strain 40A plasmid p150_40A, complete sequence	147864-147904	7	0.829
NZ_CP007451_3	3.1|1761562|41|NZ_CP007451|CRISPRCasFinder	1761562-1761602	41	NZ_CP040808	Escherichia fergusonii strain EFCF056 plasmid pEF03, complete sequence	51011-51051	7	0.829
NZ_CP007451_8	8.1|4017702|30|NZ_CP007451|CRISPRCasFinder,CRT	4017702-4017731	30	MG945498	UNVERIFIED: Microviridae sp. isolate 1641-180101, complete genome	2527-2556	7	0.767
NZ_CP007451_8	8.1|4017702|30|NZ_CP007451|CRISPRCasFinder,CRT	4017702-4017731	30	NZ_CP031644	Bacillus anthracis strain MCCC 1A01412 plasmid p1, complete sequence	56698-56727	8	0.733
NZ_CP007451_8	8.1|4017702|30|NZ_CP007451|CRISPRCasFinder,CRT	4017702-4017731	30	LT614807	Cronobacter phage Pet-CM3-4 genome assembly, chromosome: I	120783-120812	8	0.733
NZ_CP007451_8	8.4|4017899|30|NZ_CP007451|CRISPRCasFinder,CRT	4017899-4017928	30	NC_015417	Clostridium botulinum BKT015925 plasmid p1BKT015925, complete sequence	112811-112840	8	0.733

1. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to NZ_CP024285 (Escherichia albertii strain 2014C-4356 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

2. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to NZ_CP024285 (Escherichia albertii strain 2014C-4356 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

3. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to NZ_CP024285 (Escherichia albertii strain 2014C-4356 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

4. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to NZ_CP024285 (Escherichia albertii strain 2014C-4356 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

5. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to CP031286 (Escherichia fergusonii strain 40A plasmid p80_40A, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

6. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to CP031286 (Escherichia fergusonii strain 40A plasmid p80_40A, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

7. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to CP031286 (Escherichia fergusonii strain 40A plasmid p80_40A, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

8. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to CP031283 (Escherichia fergusonii strain 40A plasmid p150_40A, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

9. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to CP031283 (Escherichia fergusonii strain 40A plasmid p150_40A, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

10. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to NZ_CP040808 (Escherichia fergusonii strain EFCF056 plasmid pEF03, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

11. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to NZ_CP040808 (Escherichia fergusonii strain EFCF056 plasmid pEF03, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

12. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to NZ_CP040808 (Escherichia fergusonii strain EFCF056 plasmid pEF03, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

13. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to NZ_CP040808 (Escherichia fergusonii strain EFCF056 plasmid pEF03, complete sequence) position: , mismatch: 6, identity: 0.854

attggttattgattattggttattgattattgtatctttca-	CRISPR spacer
attgattattgattattgattattgattattg-attattgat	Protospacer
****.*************.************* **. ** * 

14. spacer 8.4|4017899|30|NZ_CP007451|CRISPRCasFinder,CRT matches to NZ_CP023822 (Escherichia coli strain 7/2 plasmid p7_2.2, complete sequence) position: , mismatch: 6, identity: 0.8

tgaaacatcattaatatcgttatgacagaa	CRISPR spacer
agtaacagtattaatatcgttatgacaggt	Protospacer
 * **** .*******************. 

15. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to NZ_CP024285 (Escherichia albertii strain 2014C-4356 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.829

attggttattgattattggttattgattattgtatctttca	CRISPR spacer
attgattattgattattgattattgattattgataatatca	Protospacer
****.*************.*************    * ***

16. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to CP031286 (Escherichia fergusonii strain 40A plasmid p80_40A, complete sequence) position: , mismatch: 7, identity: 0.829

attggttattgattattggttattgattattgtatctttca	CRISPR spacer
attgattattgattattgattattgattattgataatatca	Protospacer
****.*************.*************    * ***

17. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to CP031283 (Escherichia fergusonii strain 40A plasmid p150_40A, complete sequence) position: , mismatch: 7, identity: 0.829

attggttattgattattggttattgattattgtatctttca	CRISPR spacer
attgattattgattattgattattgattattgataatatca	Protospacer
****.*************.*************    * ***

18. spacer 3.1|1761562|41|NZ_CP007451|CRISPRCasFinder matches to NZ_CP040808 (Escherichia fergusonii strain EFCF056 plasmid pEF03, complete sequence) position: , mismatch: 7, identity: 0.829

attggttattgattattggttattgattattgtatctttca	CRISPR spacer
attgattattgattattgattattgattattgataatatca	Protospacer
****.*************.*************    * ***

19. spacer 8.1|4017702|30|NZ_CP007451|CRISPRCasFinder,CRT matches to MG945498 (UNVERIFIED: Microviridae sp. isolate 1641-180101, complete genome) position: , mismatch: 7, identity: 0.767

gctattgctgattatttcaatccaacttac	CRISPR spacer
aaaggtgctgattatttcaatcctatttac	Protospacer
.  . ****************** *.****

20. spacer 8.1|4017702|30|NZ_CP007451|CRISPRCasFinder,CRT matches to NZ_CP031644 (Bacillus anthracis strain MCCC 1A01412 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

gctattgctgattatttcaatccaacttac	CRISPR spacer
aaaattgctgattatttcaatgtaactaca	Protospacer
.  ****************** .****   

21. spacer 8.1|4017702|30|NZ_CP007451|CRISPRCasFinder,CRT matches to LT614807 (Cronobacter phage Pet-CM3-4 genome assembly, chromosome: I) position: , mismatch: 8, identity: 0.733

gctattgctgattatttcaatccaacttac	CRISPR spacer
gtcattgctgattaattcaatccatccagg	Protospacer
*..*********** ********* *. . 

22. spacer 8.4|4017899|30|NZ_CP007451|CRISPRCasFinder,CRT matches to NC_015417 (Clostridium botulinum BKT015925 plasmid p1BKT015925, complete sequence) position: , mismatch: 8, identity: 0.733

tgaaacatcattaatatcgttatgacagaa	CRISPR spacer
tgaaacatcattaatatttttatttacaag	Protospacer
*****************. ****    .*.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	3765973 : 3822474	48	Streptococcus_phage(25.0%)	integrase,transposase	attL 3820079:3820097|attR 3823763:3823781

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP007451|3765973:3822474|DBSCAN-SWA
GATACCTGGCAAGATCTATACAGATCACAAGGAAAAACTTCAGCAAATTAGCTACAACCATACCAGGAAGATTCTTGGAGGTATTGTTAATGTTGTTTTTTACGATGTTACGACTATCTACTTTCAAATAGACGATGAAGATGAAATTCGAAAACGAGGTTTTTCCAAAGAAGGAAGGCATCAAAATCCACAAATAGTTTTAGGACTTCTTGTTGGTCTGGAAGGCTATCCGCTGGCCTATGAGATCCACGAAGGGAACAAGTTTAAAGGCCATACAATACTCCCCATTATTGATGCATTTAAAGCTAAATACAAACTGGATAAGCTAATTGTAATTACCGACACGGGATTGCTCTCATCATCGAATGTAAAAGAGTTGCAGAAAAAAGGTTACGAGTTTATTCTTGGAGCAAGAATAAAAAATGAGAGTACAGCCGTAAAACAAAAAATACTTTCACTGAAGCTAGATGATAAAAACTGGGATTCTTCATTACTATTCTATAAGCGGGCAGATTGATTATATCAAAATCAGTTTGATTTGATTAATACAACTTTAAAGCAAAGAGCAATTAACCTCTATAAAAACTCCTGGAATCTATGGGTACTTAGTGCGGATACGGGAGACAATTTACAGAAAGTGGAGCGCCAGAATTATTATGCCTTTTACTCAGGAGTTGAAATTGAGAAATTTGCGGAGGATTGGAAAACCAGATTTGAGCTTAGTCATGAAACATAGAATGATAATTTTTACTATGACGTATGACGTAGAAAAAATCTCAAACGACCAAAACGAAATCAGGCTTAGGGCAAATTACATAAAAAGTGTTGCTCCCAGGTGGTTGGTTGGTACATTTGGCGGGTGTTTCTCTCAAACATACATGAACATAAAAAGTCAGTATAATATAGATGCCGGTGTGGAGTATGATATTTTTCCAAGGGATTTTCAGTAAAGTTGCTTAATCGATTATTTTAAGTTTATCGTACAGATCAAACCTATATTATCATTTGCTTTACGAGGATAACAAATCGAAATATAAACTAAAAAGTTAAATAATTCTAAAAATGTTGTATATTTAATCCTGTACGTGGTTGTTTGTTAGGTGACTTAGGAATATGGGACAGTTTTATATCTACCCAAATCGAGCAAAGGGTAGTATGAATTATTATGAACTAAAAACACATAATATGGAAAAAACTGTTTACTCGAACATGGTTGATACTTTAGAAGACAAACTTAACAAGTTAAAACAAGAAAACCATGATGTCATTACTCAGGCCGGTATAGCCATAGGTTTATGTCTGATCACTTATTCTGAGCTAAAAACCATCGTTCTTAAGAATGGATTTGAATCAGATAAAGAGGAAATTAATTTCTTCAAGTATATAAAGCCACGTCTTTGTAGTAAAATAACTTTTTACCGAAAGCAGTATATTATCGAATCTCATCGTCCAAAGTCTACGAATACACTGCAAATTGAATTTTTGCTTAAAGAAATTGAGAAGTTGCAACTCTTTTTTGAGGAACACCATGCACTTATTGAGTACTACAGAAGCAGGCAAACCATCTTTGACGATAAATATTTTAAACGAAATATCACAGAACCACTCATGGGTACAAATAATTACGCTTATTTGACAGATCCCCAGTTTTCAACTGTTTATGATGGTATCCTGGCCGATATTCTGGCTTATGAAAGTTTGGAAAAATACCTGGCCAATGAGATTCAAAAGCTACAACATACAGAAGGTAATTCGGGACCGAATGATCATGAATATGTATGGACCGGAAAACTTACCTGGCTCGCAGAGATGATTTATGGCATAGTGGAAACAGGAGTGATTAATAATGGAAATATTTCGGTAAACAAATTAATCCAGCTCTTCAGTAAAATCTTCAGGCTACCCTCCGAAGATATATACAATGCTTACCGATCTGTGTATTCTCGAAAAACAGAACCTTTAATTTTTATTGAGAAAATGCGTGAAGCCCTGCTTAAAAAGATCAATGATAAATATAAATAGGAACAATAAAATTTCATGTAATTATGGATTGGATTATCTTTGCAGCAGATAATGTAAATAATTCTCTCTGACGTGAGAGAACTACAATAATGATATTAGAGCGTTAGCTTTTATTCTTGCAAAAGAAAATCGCCAATTTTTTACACAACAAGGATATAGGTATGACGCCCACGATTCAGCGTGGGCTCAACTTATTTGTTGTGTGGGTGTTTGGCGATACCTATTTTGCAAATGCAGTTCGTAGCCCGCGCTCTTCTTATCTCCCAATTACAGTTGTATTAATAAGGAGATAACATGGCAACTAAAAAAAACAAAGAATTTGCAGATTTGATTGCTCCCTTTACTGCTTGTCCTTTTGAAAAGGTAGAAGTAGATTGTCCGTTTTCAGATTTTGGGAATCACAAAGGTTTGGACGAAATTCTAAAACTCATTGATCAACTTCCTGATGAAAAACTTATATCCTTGCGAGAGCACCATAAAACTTGTCAGGAATGGAAGATTGAAAAAGGGGAAGCAATTGTAAATATCTAACACTTACTTAACCATATAAAAAATACACCTGTATTTAGGTGTTTAATTTTCCGCATAGGAATTTCAATATTTGGCAAAACTCAAATTGTATCATTTAAAAACAATTAGTTATGCCAACAGAAATTGTAACCACTGATGATCTTCGGGAATTCAAACTCGAACTGATCAAAGAAATCAAACAGCTCTTCGCCGCCCATCACGGGCAACCTTCCAAAAAATGGTTAAAATCCTACGAAGTCAGAAAGTTGCTGGGGATCTCACCTGGTACATTACAAAACCTTCGTGTAAATGGCACTTTGGCCTACACGAAAATAGGAGGAGTAATCTTTTATGACAGTGAAGAGATCCAAAAAATGATGATGGAAAACAGAGTCCAAAACCGCTTTGAGTTTGGACGCAGGAAATGAACTATATCAAACATCAAACCGCTTTATTTGAACGGTTTGCTGATGATAACAGGATCACGCCATTTCATATCAGTCTTTATTTTGCACTGTTTCAGCTATGGAATAGAAACCGTTTTCGGAATCCTTTTCCCATTCTAAGGGAAGAGGTAATGCTTTTGGCGCATATCGGTTCTACCAACACCTATGCAAAATGTATAAAACAGCTTCGGGATTGGGGCTATATTGACTATACCTCCTCGGGAAATCTGTATACCGGTTGGAAAGTTTCCTGTATCACTTTTGATACCGGAACTGCGACTAGAACTGATACAGGAAGTGCGACGAGAAGTAATACCGGAACTGCGACTGGAACTGCGACCGGAAGTGATACCAGAAGTGCGACGGTATATAAGGAAGAAAACAATACAAACAGAACAAACAGTACTAAACAGGATCACCATAAAATCGTTAAAAATGGAAAGCAAAAGAAATCCACAGGGCGCTTCCACATCAACAACGACAAAGATTATTCGGAACCCTTATAAAGAAATTGCTCAGTTTAAAGATGGGATGTTCCGGTTTAATTTTACCGAAAGCAGAAACTGGTTGGAAGACCAGGGGAAACAAATCTTTGGTTCGCACTTTTATATCGATCCGCTTGATCATCCATTAATTCATGATCTTTTGATCTATGCCATTGGAGACAAGGAAACAGCAGGAAAACGAAATCTGGATCTGAATAAAGGGATTCTGCTAACCGGGCCGGTCGGATGCGGAAAAACATCGATTATGATGCTCATTCGATATTTCTTTCCTCCCGATAAAAAGTATCGGATAAAATCCACGCGTAAAATTAGTTTTGAATTTGAGAGTGACGGTTTTAAAGTGATAAAACGTTATGCACCGGAATCCGAAGTCAAAAATACCAAATTGCGATCACCCAATTATTGTTTTGATGACCTTGGAATTGAACAGGTACAAAAACACTTTGGGAATGAGTGCGATGTAATGGGAGAGATTCTTCTCAGCCGGTATGATTTGTTTATCTCGGAAAAAGTGATGACACATATTACCACCAATCTATCTGCATCCGAAATTGAACAGCGTTATGGTAATCGTGTTCGTAGCCGGATGCGAGCCATGTTTAATCTGATGGCTTTTAGTAAGGGTAGCGAAGACAAGAGAATTTGAAATGTTGAATATTATCAACTAAATATTTATATTTGTGGAAAATAATCAACATTATGAGGCCAAAGAAAAATATTATCTTTCCAAAACACCTGCAGATAATGGAACGTCTGGGCGAGAATATAAAGCTGGCTCGTAAAAGGAGAAAGCTGACAACGGTTCAGGTAGCAGAGCGTGCCGATATCGACAGAACAACCCTTTACCAGATAGAAAAAGGGAATCCGAAAGTATCAATGGGGGCTTACTTTAACGTGCTAAGAGTTTTAGGTTTGCAGGATGATTTTCTGAAACTGGCTGCCGACGATACTTTGGGTAGAAAATTACAGGACCTGGATTTATTGTAAACCTCCTTCACGAATAAAGAGCTTGAAAATATGGCAACAGCAAAAACAGATATATACGTTTACGCCCACTGGAAAGGGCTTTCGGATCCTCAGTTGATAGGAATCCTTTCTGCCCATGCAGCCAAGGGAAGAAAAGCATTTAGTTTTGAATATACTGCTGCCTGGCTAAAATCGGCGGAATACCGCTTGCTGGATCCGGATATTCAGTTTTATGGCGGTCCGCAATTTCCGAATAACAAGGAAAATTTTGGCCTGTTTCTGGATAGTATGCCGGATACCTGGGGAAGAACATTGATGAAGAGGCGTGCAGCACAGGAAGCTGCTGAAAAAGGGGAGCGGGCAAAAACGTTGTATGAAGTGGATTATTTACTCGGAGTACTGGATGAAAGCCGTATGGGAGCTTTGCGCTTTAAAACCGATCCCAACGGTCCTTTTCTTGATAACAACGAACAGTCCCCAACACCGCCTTGGTCTTCGGTTGCTGAGTTGCAGGAAGCCGCGAGTAATATTGAAAACGAAACCAACAACGATGCGGTAAAGAAATGGCTGGCCATACTAATTGCACCGGGCTCATCACTGGGAGGAGCCCGACCCAAAGCCAATATACTGGATAAAGATCATAACCTTTGGATTGCCAAGTTTCCAGCTAAAAACGATACGATAGATAAAGCGGCCTGGGAATATCTGGCCTGGCAACTGGCTTTAAAAGCAGGGATCAACATGTCAGAATGCAGGATCAGTAAAGTAGCAGGAAAGTACAACACCTTTTTTACCAAACGTTTTGACCGGGAACAGGAACAGCGGATTCATTTTGCCTCTGCCATGACCATGACCGGAAATAACGAAGATACGATCAGGGATAATCCTGCAAGTTACCTTGAAATGGCTGAATTTATTCAAAACCACGGTACCCGTATAAACGAGCATCTGGAACAGCTATGGCGTAGAATTGTATTCAATATCGCAATTTCCAATACGGATGATCACCTGCGTAACCACGGTTTTCTTTTAACTGAAAAAGGCTGGGTATTGTCACCGGCTTATGATATCAATCCCTCGATTGATAAAGATGGCCTGGCCTTAAATATTGACATGGATAACAATGCCCTGGATTATGAGCTGGCAAAAAGTGTAGGCCCGTTTTTCCGGTTGGATAACAAGCAAATGGACCGGATAATTGATGAAGTCACCACTTCGGTAAAGAACTGGCGCAAAATGGCAAAGACTATTGGCATCTCCAACAGTGAACAGGACTTGATGGCCAAAGCATTTCACATTTAATTCATCCCTGCAATTTCTATTGGCTAATTCCTGTGCATCGGCCCATTATTCCGGTGTGCTGAACCAGCTTTGCTCATGATTCGCAGGTTTTCGCTCTCCTGATGATATCCCGGAATGAAAAGCCTCATTGCACCACACAGCAAGAGCCGGAACTCCGGTTCGCTTTGCTCCATTCCTTCCCGTAGTTTCCTTTCACCTGCCCGGATTTTTGGCCACCCACTTTCCACCCCAAAGCAAAAATCCGAAGTCATGTTCCAGTCACGCCATCCCCATTCACAATACTTCCCTGCATTCCAGCACTTGCCTTTAGCCTTCCCGCATAATAACTTTAACAGGTATTGAGGTATTTCTCCCGTGCCGCGGCTCTTTTCCCTGACGGGCTCCGACACTCCCTAAACCCGTTCGCGCACTCACGGGATATGGTTGTTAGTCTCGCCCTTACAGAGAAAAACGCCTTCAGGCACCGCACGGAAAGAGCCCTCTTTTCGTTTCACTTCTGTCCGGCACTTTCCTGAAGCCTGCACACATTATTACTTGACAGTTCATTGTTTTTTAAAGGTTGAAAACAAAAAAAAGACGCCCAAAGATCTCCATCCTCCGCCAATGCCCACGCTCATTAAACCGCAAGGCTAAATAAATGTCCCGTTTTATTGGTTTAAAAGTTTGATTTTGAAAGATTGCAGGGACGGGCCAGCCTTGCCGTTTATCTCCGGATGGCGGTTCCATGGGCTTTCTTCTCTTTTTTTTCTTTTTTTTCTCTTCTTTTGGGGATTATTTTATTTTACCAAATAAAATTAAAACAACCTGTTATTTAGTGTGGTTGAGGTTATTCAGACCTGAAACATACTATTTCAATTAAATTTTATGATATAGAGGGGATTTATTTAACCATATAAAAAATACATGTGTATTTAGGTGTTTTTTTTCTCCAGCCCGACTGCTGAATTTTGCCAACAGTTTCACCTGAAAAAATACGAATCATGTTTGGCTTAAATGAAATTACCTGGAAAGAATTTATTCAGTTTTTAGGATTGCTTCTACTCTTGTGGTACACTGTTTTGCTGTTGTGGTCCTGGTATAAATCGCAGAAGAAGCAAAACGGTTTATTTGAAGATGACCGGGTGGCAGGTGACACTGTGATGACAGGCGTGCAACCGGTAGTCGTTTCAGCCTCCAACTTCCCGTCAAAACTAATTTCATCGATATCCGAAAATTCCATTCCTCTGGAAGTTAGCGTCTATGAAGAGACCGGTGTAAATGATGGAATTCATATCGATTATTTCTTAAATGAGTTAACCGGGAAACTGGAAAAACTGCTTCCCGAAATTCAATACCAACAATAACATTTAATCACAAGAAAGATGAAAAAGAGTATTCACGGTTTTTTCAGCAGGGGCATGGCTATCGTTGCCATGATTGTTTTAGGAGTGTATAATACAATGGCACAAAGTTCTGCCGGGATTGACCAGGCGACCACGGAAGTAAACTCCTATGTGGATCCGGTGGCCAACCTGATCATAGCCATCGGAGCTGTAGTGGGCCTGATCGGCGGTGTCCGGGTATATATCAAGTGGCAGAGTGGAGACCAGGATACCCAAAAGGCCATCATGGGATGGTTTGGTGCCTGCCTCTTCCTGATTCTGGTTGGCGTTGTCATTCGATCATTCTTTGCTTAAGAAATTACTGGTGGGGAGAACCGGACAGTGTGACCAGGTAGTTATTGAGGGACGGTCCTGTATCGTTCCTCAATCTTCCCAAAAATCTAATTCAAATAGAAAAAATGAAATCATACACCATTCAAAAGATCGATACCAACCTCTACATCAAAGGATTCTCCGGGCAGCTGGTTTACCTGGCACTTTACGGAATCCTTGCGACACTCATTCTCTTTGTAATTCTTTATATCGCTGCCGGAACTTTTGTGTCAGTTGCAGTCTGCGTACCTGCCTTTTTTGCCTGGCTGTACCGACTGAACCGGATTCAAAAAAATTATGGTCACCGGGGTTGGCATAAAAAACGGATTGCCCGCCAACTCCCTGAATTTATCACGATCAAACAACGCATTTATCAGTAGTAACATGAGAGTAAAACCAATACAAGTAAGTCTTCCTGTACTGGGTTTTGACGGTGATATTCTGATCTCCAATAACCTGGATATGGGATTCGGACTGCGACTATTTTTACCGGAGTTGTTGTCTTGCAGCACGGAAAAATTATACATGCTTCACGATACCTTTCAGCGGGTAGTAAATATCCTTCCGGAAAATACCCTGCTTCACAAGCAGGATTTCTTTTTCCCCGAAGAATTTTCTTCAAATAGCGATAGGGCATTGAAGAGAAGACCAGGTTTAACCGGAAACTACCTGAGTCATTTTTATGGGAGGAGGTATCTGAAACATGAATGCTACCTATACGTGAGCCTGTTGAATACCGGCCTGTTAAAAAACTACCTGGGATCTTCGCTAATCTTTTCACGCAAAGCCCGGCTGGAGGAAGCCCGTCTGCAGGAAAAGATCCGGGAACTGCAGACCAACCTGGCCTCGATCTTCCGTCAGGCAGGAATAGAAAGTATACCGATAACCAGAGAACAAGCCATGGGGACAGCCTCTGAAATTGGCCTGATTGAACGCTACCTGACATTAAACTTTAGAGAAGGACAGCCTTTATTGGGAGGAATTGATTTTAGAGACCGTTTACGGGTGATGGATCGTTTTGTGGAAATTCTGAGTCTGAGTGACCATTCGCACTTGCCATCAGAAGTACGCCCCACAAGCGGCCATCCCCGCACCGGGCTGCCCGTTTCACTGGTTTATCCGCTGTGCTGGCACCTGCCGTATGCGCATATTACCAACCAGTTTATCTATGTGCCGGGACAACAGGAAGTAAAAGCAGGGCTGGAAGGCGATTATAAAAAGATCTACAGCCTGTCAAAATTTTCCTCAGAGAACAAGATCAATGCCGGACTGATTGAAAATTTTCTGGACACCGTGCAAACCTCGGGAGAGAAGATCGTTAAAACCCACTATAATGTGACACTGCTGGATACTTCGATCTCAAATTTGAAGAAAATCAAAAGCGAAACGGCCACAGCCTTTTCACTGATGAACTGTTTTCCTTACCAGCACACCTTTGATCTTCCGTTTTTATTTTTTGCAGGTTTACCCTTCAGCACTCAATTACCCGAAACAGAACTGTTTTTGACACAGGTGCCGCAAGCCTGCTGTTTGACCAATTATGAGGGCGCAGTCAAGAACTCAGATTCAACATTTACTATTCACCTGTCGGACCGGATGGAAGGCTGCCCGGTAAAAATTGACCTGTCGGATGAACCCATGAAAAAGAACCTGATCCATAACCGCAACAAAATCATTATCGGCGGATCGGGATCCGGAAAATCCTTTTTTACCAATCACCTGCTGCGGCAATATGCCGAAAGTAAAAACTGCCATGTTGTATTGCTGGATGTGGGGCGCAGTTATGAGATCCTGACCCGGTACCTCGATGAACGACTAAAGGAAAAAGGGGGAGCAAAAATGATTGAGTTCTCAGAAACAAATCCCATTTCCTTTAATCCTTTTGTGGTGGATGGTTCACCGGACCTGGAACGCCGGCAAACCATTCTGTCGGTTATTTACACCATCTACAAAGAGCAGCTTACCGAAATGGAAAAGGATGTCATTGCTTTTTCGGTGAATCGCTATTTTGAGACAAAACGTAAAAAGAAACGTTCGTTTAACGATTACTACGAGTTTTGCAAGGACATCATTCCACGGCTTGCCAGGGAAGAATCCATAGAGTTTAACAGCAACGAATTTTTCTTTATCCTCAGTAAATACTACAAGGGAGGAGAATACGATTACCTGCTGAATAAACCCATGCAAACCGATGAGTTTTTCTCTTGTCCCTTTCTGGTATTCGAGCTGGATGCGATAAAAGACCATCCGGTTATTTTTCCGGTGGCCACACTGATTATCATGGATATCTTCCTGCAGAAGATGCGGAAGCTGAAACGCACGCGAAAAGTGATCTGTCTGGAAGAAGCTTGGAAAGCCATTGCCACACCACAAATGGCGGATTATTTAAAGTATTTTTTCAAAACCATCCGAAAATTTTTTGGTGAAGCCATGGTGGTAACACAGGAAGTGGATGATGTGATTTCCTCACCCATAATCCGTGATGCTATTATCAACAATGCCGATACCCGGATTCTGCTGGACATGGGGAAATTCAAAAACAAGTTTGATGAGATCAGTCGCTTTTTGGGATTAAATGCTTTTCAAAAAGAACAAATCCTGTCGATAAATAAAAATCTTCCATCCAACCGAAAATTTAAGGAGGTATTTATCTCGCTTGGAGAATATTCCCGTGTATTTGCCCTGGAAGTTAGCCGGGCTGAATACTACTGTTACACCACCGAACAAACCGAAAAGGAACAAGTGCTGGAACAACTGATCGCAGACCAATCTATTCTTGAGATTTTAAAACAAATGTAAAACCATAAAAACAAAAAGAGCATGAAAAATTTAATCGTATTCATTTTAATTGTCATTCTTGCAGTAGCTGCAAGTGCAAGCAAAGCTCAGACTCCGGTAACGGATGTCGGAGCCGGAATACAACGCGAAGCCCTCTGGACAGAGGAAGAAGGAATTCTCTCAAAAATCAATCTTTACAATGTGCTGATCAAAGCTCTGAACGGAGATATCAAAGGGCTGACCGGAGAAATATTAGGCATCGATCAGAAAATGCTGGAAAGTCTGGAAAAGGTTTCTCTGTTGATCAAAGATTATAAGCGTATAAAGGAAACCAAAGACATCCTTCAGCAGATCATCGCCATTTATACCGACAAAGTGCCTCTATTAGTACAGGACGGAAATTTTACCACCCAACAGGCGGCTGCCATTGTGCAGAGTTTTGACCTGATTCTGGATGATAGTAAAGCATTGGTCACATCGATTTTAAATATCATCGTTAAAGACAACCTGTTTATGATGGATGATAAACAGCGTTACGATGCCATTAACGGAATCTACCTCAGTGTAAAACAACACTACGGAACAATCTGCTACCTGCACAACAAATTGATGTATGCTTCCTATTTGAAAAGCCATGACAGCGGCGATCTGGAAGGTTTTGCCATGTATTACAGTCTGTATCACTAAGCAACTCAGAACAATGAAACGAATAACAATACTGCTTATGATGGTACTGCTGATTCTCACGCTAACAAAAGAGACAAAAGCACAAATCATTGAGATCAAACCCTGGCACGGTTACTATCCGGAGATGGAAGGAACTTATCCGCTGACTTTTATTGCCTTTACCGGCTGGCTGATACCCATTCCTCATGTTTTTGTACGCACCTGGCCAACGCACTATTATGTGGAAGTGGGTGCACTGCCCGTTACCGATGGAGGAGAAATTGCCGGAGAACTAAAAACCGGTCTTTTACGATTGGTCGCGAAGGCCATCGAACGTAGCCAGATGAAAGGCAGACAGGAAGAAACAGAAGGAATAAAAGTCAATACGGACTTTACCCAACAGATAAGTGATAAATTATTTGATGCCCGCTCGGATGAGTTGAATGATATCTATAAGCTGGCAGCACAGTTTATCAAACTCTACCAAAAAGTCAGCAAACTGGGAAGCCTTAACAACTCAGCCCAAATCCATTCGATCTATGAGAAGGAAGCTGATCAGCTATTAATGCAGTTTTTGATGGTGAACTTGTTTCAGACCGATCATGGGCGCAAGCTGGATGCCTTCTCTGTACTCAGTAAAGAGCTTTGGAAACTACTGGGCGAGTTGGATTATACTCACGGCAAACTGCTCTTTTTTAACAGCTTCGAAAGTCAGCCGCTGAGCTATTCCTTTTTAAGCAAATAACAGTTAACTGCAAAACAAATCAGTTATGATATTACAAGTAATTACAACTAATGATTTTTTCGCATTTACCGATACGCTGGTGGACTCCGGTGTCAACCATGCCCGAATTCTTGTAGATATGGCAAGAGCCATTGGAGGTATCGCTGCCTTCTTTTACATCGCTAAACGGATCTATGAGCAACTGATCGCTGATAATCCTGTATCGATTCTGCCATTGTTACGACCTTTTGCATTGGTGCTGGTAATCACTTTCTGGGGACCTTTTGTGAATCTGCTACTTGCACCCACAAAAGGATTGACGCATTTGTCGGAAGCTGTTTATGCCGATAAAAAGCACATCGTAAAAGAGCGGCTGGAAGACAAACAACAATCCATTCTCTCCACAGATTTGCCTTTGTTTTATGAAAACGAAGAAAAGGAAGCTGATCTCTGGGACAAAGGAGTAAACCTGATCCTGACCACCTACAATATTTTTAGCGGAAGGGCGATTCAAAACCAGATCAACTTTTATATCATGGATGCTACCCGGCAACTGTTGGAATCCTTCTTTGAAGTACTGGTTTACCTGATTGCTTTTCTTCGAACGGTGTTCTGTGTGTTGCTGGTGATCTTTGGTCCGCTGGTGTTTGCCCTGTCCATTTTTGATGGTTTTCAGGACAATTACCTGCAGTGGATCGCCCGGTTTATCAATGTCAATCTTTATTTGCCCATAGCCCTGCTGATCCTTTCCATCGTGCAGGAGATCCTGATCTATGTACTGGAAATGGAAATTGCCCAGATCAATGCTATGCTGATCTATGAGCCCAAACTGTTTTTTGTTTCCAACCTGATTGTGCCGGTTTGTGGAATTATCGGAATGGCAATGGTACCCAAAATTTCCTCATGGATCATACATGCTTCAGGAACCAACTCCGGAGGAGGAAGACTGGTACGCACCGCAGCAGTGATGGCAATTACAAAAGGAGCCATGAAATGACAGGTCAATTTTTCATCTAAAAATATACAAGTAAGAAATGCAAAAACAATTTGATATACAACGCAAGTTCCGCTTTATCGTTTATGTGCTGGTGCTGATCAGCCTCTCTCTAATGGGAGTTAGCAGCTACATTTATTACGAGTCGGTGCAACTGGTGGAGCTTTCGAAACAAAAGATCTATGTACTTGACAACGGTAAATCGCTACTGGTGGCTCTTCGGGAAGACATCAGTGAGAACCGCGATGCGGAAGCCCGGGACCATGTTAAACGCTTTCATGAGCTGTTTTTTACCCTTGAACCGGACAAAACCTACATTGAAAACAATGTCAGGGAAGCGCTGTATCTGGCCGACCGGAGTGCCATGGAGCAGTACCAGGCCTTTAAAGAGAATAATCTCTACAACCAGGTGATTGCTTCTGATATCAGCATGACCCTGCAGACCGATTCCATAAAGCTGGACTTTTCTGCCTATCCCTATCACTTTACGTTTACCGGCAGGCAGAAGATTGTCCGTAAATCCAACATTACTATTCGTAGCCTCAAAACTTCCGGCTACCTGAGAAATATCTCTCGGACAGATAATAATCCACATGGTTTCCTGATGGAAAGCTGGCGGATCGATGAGAACAAAGACCTTGAAAGCATACGAAGAAAATCCTTTTAACAGCTGATACAATGAATAATAAAAACAACATTCCAAATCCAAAAGATATCAGCCGTTTTACTCGCTGGGTAAACGAGCTGGACGATAAAGACAAAACACTGGATCCCTTAAAACGAAAAAGCAAATGGATTTTGATTACTGCTTTTTTGTTTGCCCTGTTCGCCATCTCTTTTATCTGGTTCCCGACAGGAAAGGTAAAACCACAGAAAGTGGAAGCACCCCAAGCAGGACCGGTAATCGAAGCACCAACAAACGCTGGCCATTCTGCTTTTGAGCTGCCCGTTGATTCATTTGAAAACCAATTAAAATCATACATCAATGAAGAAAATTTTGATAAATAATGAAGCGCTATTTATCCTTCCACTGGCATTATTGCCCTTTGTGGTTGTGATCTTCTGGGTATTGGGTGGAGGAGGAGTTCAAGAGGAAAAAGAGAAGCTTGCTCAGTCACCGAATAAAGGAATAAACTATGACCTGCCGGATGCCGATAATTCCATAGAGATCTACGATAAAATGGAAGCTTATCAGAAGGAAGAATCACAAGTGGCACAGGTGTCTGAGGTTGACGTAAATGATACAACGAAGCAGGAAGATGTCAGTATTCAGGATACAATGGATCTGGACAACACCATGTTGGATGAAAATGCCAGTCAGAATGAAATTCTTGCTCATATCCGAAATAAAGAAAAACAGGTACAACAGGAACTTCAAGGAGAACCGGAAGTTCGAAAGAGTGGGAAAAAAACATCTCCCCAATACCAGATTAAGCCTATAAAACCTGTAGTTAAGAAACAGGCCGAAACAACAAAATCAGTAACTCCGACAACCGGCATCGGAGAACTGGATGAGATCATCGATGAAAACATCGTGCTTAACCGAAGAAATGATTCACTGAAATATACGCTTCAACAAACTCAGGGACGGTTGCAACAGATCGAGGCCACACAAAACCGGTCCTTTACCCTGGAGAAAAAACGCTCATCCGGATTTAATCCAAAGGAGACACCGAAGCAAGAGCTGATCAAAGCTGAGATCTATGAGACAACAACCGTCCTGAACGGTAACCGGGTAAAACTGCGCCTGCTGGAAGACACCCGGATCAATGCTCAGAAAATACCACGTAACACATTTATCTACGGGATCTGCAAGATCAAAAATGAACGGCTGCTGATTGAGATCACACAACTGCCTGTTGAAAATTCTTTTGTCCCGGTGAAGCTCACGATCTGTGACATGGATGGAATGGAAGGACTTTATGTGCCTGATAATGCCGCACGAAAAGTTTACCAGGAAGTCGGCGCTTCAACCAATACTTCGTCACTGATGGGCGTTACCAACAATCCGCTAACCTATACCGGTATCCGTGCAGCTGATCGGGCTGCCCAAACCATGCTCAAACGGGTACGCCTGAAAAAAGTAACCGTCAAGAAAAACACTCGGATTTATATCATCAATCAAAAATAATCGTCATGAAACAAACAATATTTATCATCGTATTCTTTCTTTTTTCACTGGCAGGATATGCCCAGAATCAAATAGAAATCTGTCAAAACAAAACCACACATCTGATCGCCGAAGAAAAAATTACTTATCTGCAGGTTGGTGATCCTGATAAACTAATTGCCGAAGTAGTTCCCGAGCAGCCGAATATGGTCCGGGTAAAAGCTGTGGATGATTTTGAAGGCGAATCTTCCCTGACAGTGGTCAGTGCCAATCGCTCGTATTCCTTGTTTGTAAAGTATTCTGATGCGAATAAGATTTCGTATCAACTGGAAGATTTTATCGGACAGATTGCCGGAAATATCAATATCGGTCCGGTACCGGAATACCTGCTAAAAGAATTGTGTGGCCAGATTCTCAATGATTGCACCCAATCTCCGATTCGGACGAGAACAAAAAAAGACGGGATTATATTTCGTTTGCGGAATCTTTACCTGAAACAAGATTTGTTGTTTTTTGAGCTGGAGATTACCAACTCCACAAATATTGTTTTGGATTTGGAGGCCATTCACTGGTGGATCGATGACAAAAAGCAGGTAAAAGCCACCAATGTACAGGAATATCAGGTAGAAGAATTGTACCGGCATTATAATTGGGAGCGCATACCTGCAAAAACTACACTGCGGGAGGTTGTCGTATTGCCTAAATTTATTGTTCCCGATAAACGCATCCTAAAAATCGAACTGTTGGAAAAAGCCCTGGGAAATACCGGAAGAAAACTAACGCTGGAGGTGAAGAACAAAAACATCCTAAAAGCTAACTCATTCTAGTATTCTGATCTTCTAATATTCTAATCTTCCAGAAAATGCTCAACGAATCCAGGGAATTACAACGCCTGCACGAAGGTTTCAGGTTCTTTTCTTACCTCTTACTGTTTCTGACTTTATACATTGACCAGTTGGTATGGTTCAGGGAACAGGGACTTTACATTCCTGAATTTTCTATGGTGTTGGAAAAGATTCTTAAAATAGAATTTCTTTCCAATACCCTTTGGGCAAAGACAGTTTGCATAGCTTTTCTGGCTATTACCTGTATTGGAACCAAAGCAAAAAAAGACAGGGACCTGAAAGTTTCTGCCATCGTTTTGCAGGTACTTACTGGCTTGCTGATGTATTGGGGAAGTCTGTTGATTATTGTTACAGTTCCCTTGGGCTACCTACTGTTGTCCTTCTTTGGATTTGTACTGCTGAATATTGGCTTTGACAATATCTCCAAGCTGATCAATGTGAACCTGATGAAAGACCGGTTTAACCTCGAAAATGAAAGCTTTCCCCAGGAACAAGGCTATGAAGAAAATGAGTATTCCATAAATCTTGAAACGGTTTATCAATACCGGAACAAACAGCACGAAGGCTGGATTAATGTGATCAATCCATTTCGGGGAACCATTGTGATCGGTACTCCCGGTTCCGGTAAATCTTATTCCGTAGTCCTCCCTTTTATCAAACAACACCTGGAAAAGGGATTCTGTATGTGTGTTTATGATTTTAAGTTTTCGGACTTATCAGGGGTGGCTTATAATCATTTTCTTAAAGCCCGGAAGAATAAGAACCTGCCCGAGCAAACCCGTTTTTATGTCATTAATTTTGATGATATCCGAAAATCTTATCGCTGTAATCCACTGGCACCGGAACTGATGGAAAGCCCCATTGATGCTTTTGAATCTTCACGCACCGTGCTTTATAACCTGAACCGGGATTGGATTCGTAAGCAGGGAGAATTCTTCTCGGAATCAGCGGTAACCTTCTTTGCTGCAGTGATCTGGTTTCTGAAGAAGTACAAGAACGGGGAATATTGCACCCTGCCACATGCCATTGAATTGCTGCAATTGGAATACGACGATCTGTTTGAGGTGCTTTCGCAGGAAAAGGATGTGGTGAATATCATCAATCCTTTTATTAACGCACACAAGCGGGGAGCTAACGAACAACTGGAAGGACAGCTGGGAAGTTTGAAAATTGCGATCTCCAAAATTATTAGTAAAGAAATCTACTGGATTTGCTCGGGTAATGATTTTTCGCTGGATATTAATAATCCTGAGCGACCGAAGGTTGTTTGTCTGGCAAACAACCCTCTTCGCATTGAAATGTATGGGGCTGTACTCTCTCTCTTTATCACCAGAATGTTGAAAGTGATCAATCGAAAAGACCAACAAAAGACCTCACTGATATTTGATGAACTCCCAACCATTTATTTTCGTGGGCTGGACACGCTGATTGCAACTGCCCGGAGCAATAAAATTTCTACGCTGCTGGGTATTCAAACCATCGATCAGCTGATTCGGGATTACGGAAAAGAGCAGGCAAATGCAATATTAACCAACATCGGAAATGCATTTGCCGGTCAGTCGGTAGGAGAGACAGCCCGGTTTATTCAGAGCCGTATGGGAAAAATATTGCAGGAACGCCAGTCCATAAATATCAACCGGAATACCCAGTCATCAACTTTCTCAACTCAAATGGACTTTTTGGTGCCGGAAGGAAAAATTGCCACTCTGCCGCAAGGATATATGGTGGGGCAGGTGGCCGACAATTTTGGGCAGCAGGTTGGTCAGCGCAATTTTAACTGCCTGATTGATGTGGATACAGACCAAATTGAAAAGGAAGAACGGAATTATAAGGAGATCCCCGAAGTATATAAAATCGATGACCTGCAGGCACTCCTAGAAAACAACCGTACCCGGATCTGTAATGATATCAGGAAAATCCTTTTGGAAATCAGTAAGGACTCAAAATAGTCACCAGTAATTATTCACCTATTAAAATTAATAAGTATGGAACAAAGTACAAGAATTAAAAAAGAAGAGATCCCTTTTGACAAACTGGAAAAAGTGGGCGTAGACAAGGAATTTGTAAACCGCATGGAACCACAGGAACTGAATGCTTTTTTGAATGGCTACCGTTCAGATAAACTGTATACGGTAAATGCTAAGATCAATGACCAGGAATTTCGGATTCCGGCTAAACTACGACTTCAGAAAGGGGAAGATGGTGCAGTTAATGTAAAAGTGCATCCCATTCAGCGCCTGAATATCCCTGAAAAATTTATGGGACACAAGTTTACAGAGGAAGAACGCAATGCGCTGCTCAAGGAAAAGAACCTGGGAAAAACCATTGAACTAAAAGGAATTGATGGGAAAAAGGACAGTTATTACCTGGCCATCGATCCTAAAACCAATGAGTTGATTCCGCTACGTGCCAGCAATATTAAAGTACCAGGGAAAATAAAAGGAGCTACTTTGTCGGAAGAGCAAAAGCAAAAACTAGCCGCCGGTAAAAAAGTATTTCTGGATAAAATGACCGGCCGGAACGGACAAAAATTTGGTGCTACTCTTCAGGTGGATGCAGCCAACCGAAGTATCAACTTTTCTGGTTTTAAACAGGAGAAAAAACTGACAGAAGAACAAAACGAAAAACAGACAAAAACAAAAGGGGCTAAACAAAAAGTTGGTTAGCCTTAATCCGGTTGATTTGAACTTTGAAAGGGGAACAGGAAAACTGTTTCTCTTTCTTCTTGCAAGCCCGAAGTCCTTGCTATAGCTGGTGGGGGAGGGGTTGGCAAGATGTGATTTTGTTTCACAAAATCGCTTGTGCCTGTCCGGCAGGGACTTTTAATCTGGCGATTAAAAGCTTGATTAATTCTGCGAATTAAAGTCTTAACAGTTAAAATTTAAGATAACATGTCACGATACAGAAATCCGAGAGTAAAAAAAACAGAAGCTGTTCGTGTTCGTTTTACTCCCCTGGAAAAGAAATTACTCCGCGATCGTTGTAAAAAAGAAGGCTATAAAAATCTGAGTAACTTTTTTCGGGCCAAAGTTATGCGTCATCGTGAAATTAAAAAGATAGAAGTCTCCTCTGAATTTACCTCCCTGATCAAAAGACTGGATTTTAACCTGAATAAAATTGGTGTGAACCTTAACCAGGTAGCCAAACAGATTAATTCGAAAAAGAACAATGAGCTCACAGCTACCGACCGGCATACACTAGACAAGGTGCAGCAAGAACTAAAGCAGTGTTTTTCTTCCCTTCAGAAATACATGGATATAATCCGGTAAAATCATCTTTAACTTTTCGCCTATGGTAATTGTGATGCATAAGAGTGCTTATACCGAGAACGTGATGATGTATAATGAAAAGAAGGTAAACGAAGGAGTTGCCACGTTCTTTCATTTTAAAAATACCAAGTCGGCTAATCCGTTTAACTACGATGAAAAACACCGGGTAAAAATCTTGCTGGACATTGAAGACGAAAATCCCCGTGCCTGGCATAAGTGTTTTCATGTATCGTTCAATCCATCCAACGAAGATTATAAAATCATGAACGATGGCACCATAAAACAGGAAATAGATAATATGATGGAGCACATGGGCTATGGACATCAACCTTATTTTGTGTACCGTCACGAAGATTTAGAACGTGTTCACTTTCATGTGGTATCAACGCGCATTGATTGTATTACACATCAAAAGATCAAGGACAATTTTGAGCGGCTGAAGATGCAACGCTTTTTACATCAACTGGAAGAGAAATATAATCTGCCGCTGAAAGAAAAGCCTCAGGAGATTAACTTTCGTTTCTCGGTACGCAGCAGAAACATTAAAGAGAACCTGGAAAACTTGTTTAAACACCTGAATGAAAAGGATGAACTCACTACTAAAGATTTGTATGATCAGGCTTTGTTATCTTTTAAGGTAGAGGTTCAAAAATCAGGAAGAGGCCATATTGTTGTGGTTCTGGGCGACGATGGAAAACCGGCTCGCTATCCGATTCGCTTATCGAAGTTTAAAAATAAACCGAAGTTTTATTCCAAAGAAAACAGGTTGGCCGAACAAAAAACGGTTGAAAAACAACAATTACAACAACAGAAGAAGCCAGACATCTCAGAAGTTGATTTAAGATCAGTTGGAGTAGTGGCCAGAGATCTGAACCGCTTGGTGGAACGCAGTAAATGGCATAAAGAAAATCCGAAGACAAAATATAAAACCCGAAAAAAGAAACGAGGAAAACGCTTCTGACTGAAATTTCGGGATGCCCGAAGGCTATTCTCGATTTTTTAAATAAGAACTACTGAATATAAAAGATTAAAAACCACAGATTATGTTGTCAGATTTTTTTAGAATTAACTTACCTTACGGTATTGCAAAAAACAAAAACAACGAGTGGATGGCCTTTAACCGGGAATATTTGCCACTAGGTTTTAATAGTGAGGATATTAAAGGACTTCCGGGATTAAGCTATCTTGATCTTCCTGTTTATACCGGATATGAAAATGTGCCGGATCATTTACTGTTGGAATTAGCAGACGAAGACCATGCTGTTCAGCGCGATAAAAATGGGGAAATAATCCGCTTGTTTCTGTATGACGATGGAACGAATCCGGTTAACCATTCGGAGCGAAGAGAGGATCTATGGCAAAAGTATTTTTGTAAGCTGCAACGGCTTTCGGAATTAAAACGAAATAGTATCTGGAAATATATGTAATGAATAGATGATAGATTAATAAGTACTAACAAATGAAAGAAATAGAAATTAAGGACAAACAAAAATACCTGGATGAGAATTACATTTTTGAGGATATCCCTGAGGTGTCAGACAGAAAAAGGTGTCTTCATTGCGGAGAGATAATAGTAGTAGGGAACTATAAAGTATATGCAAACGAGCAGGGGGATGAATATATTTATTGTCCGAATGCTCCCGAATGCGATGGTACTATCATTGACTGGATGGATGTTTAAGTATAAATTAAAAAGAGCCATTCAATAATGGCTCTTTCAATGTTAACCCCCAAACACACAGATGATCAGACCGATCATCTATTGTAAATATAATTATTTTAAGATTAAGTGTGGTTATTAATACGATCTGAAAAATCTATCGATTGACATTTTCGATTTGAATCACGCTTTTTTTAGATTTTTGCTGGCCAATTACATAGCTGGGGAAGCCTAAGATCAGTGAGTTATAAGGTTGGTAAGATTGCTGGCTTTCGGAAACCCGCTTGCAGTAAGGCTTAGGCCTATTGAGGAGATAAACTACACACAAGTAATTGAACTAGTGTTGTTTTATCTTTTTATATTGTTAACTTTAGGCTTCGAATAAAAACCATAATGCATTGATCACGCACCCGAATATAAGATTTACAGAAAAAGTACGGTTATACCCTCAAAACGGACGGATAACCCAACCTCATAATAAAGTAATAAATCGAAAGATTGGATTACATATTTTAGCTACAAGTGAAAAACAAGAAACCGAACATGGTAACCTGAATATAATATTAGAAAAAGAGGATTAATAATATTGAATCGTTAATTAACGGTTGGCGCAAGAAAAGATTGGTTTTGCACTCCCGTTTCTACGATTCGAGATGGTTAGGGAGGCCAAACTTGTTGCAAACATATTAAATCGTATATGCTGACCTACAAAATTCAAATTACAGAAGAGTGAAATTCCCTAGTTTAATTAGCTATAAAATAAAATTTTGAGTATGTGGAAAGATAGCGAAACAAATGTAGATTTACTTGACTTTGATTACCTTATTGGTATTACTAAAGACATAATTATAAATGATGAACTGTCGCCTTCTAGTATTGGTGTCTATGGCGATTGGGGAAGTGGAAAATCAAGCTTAATTGAGATGACATTAAGCGAACTATCAAAAAATGAAGATTACCTATGTCTCAAATTCAACGGTTGGTTATTTGAAGGGTATGAAGATGCCAAAACAGCCTTAATTGGTACTATATTGGATGAAATCAATGGCAAAAAAACACCCGCAGGCAAAGCGAAAGATGTAATTCAGAGATTATACAAAAACATAGATTTTTTTAAGTTGGCAAGCAAAGGGGCTAAGTATGGTCTTGATTTTCTATTAACAGGTGGAATGGGTACTGTCGCCGATATCACAATACAAAGTATAATTTCAAGAGTTAAAGATAAAGCATCCGATATATCAGAAGGTGATATTAAAGGTGTACTAAGCAAAACATTAAAAAGCGATGAAATACGAAAGAGTTTAAAATCTTTTCATCAAGATTTCGCTGAATTGCTAAAAGAAACGAAAATCAAACGCTTAGTAATCTTCATTGATGAATTAGATCGATGCAATCCAGACACAATTCTAGCCACTTTTGAAGCCATTCGTCTATTCTTATTTGCCGAAGGTACTTCCTTTATTATTGGAGCGGATGAACGACAGGTAATGTATGCAGTTCGTAAAAAATTTCCAGAAACGAAAGGTAATAAGATTGACATTGGAAAAGAATATTTAGAAAAGATTATTCAATATCCTGTGAAGATACCACAACTTGGTATTAAAGAAGTACAGTTTTATATCATGTGTCTTCTTTTAAAATATGAACTAAAAGAGAAACATCTTCCGATTCTAGAATTTATTCAAAAGGAAAGACAGAAAGATTTTTTAAACTTTTCAATGTCGTTCAGCTTAATTGAAGGCAAGTTTCCTCGAGAAGAAGAAAAATTGAAAGAAGTAATTTCTTTAGCCAATCAATTATCTGCAGTCCTTTCTAAAGGCCTAAATGGTAATCCGAGGCATTGTAAACGGTTTTTAAACTCCCTTTCAATGCGTATTACAATGGCGAAAATAAAAGGAATTGATTTAGATAAGAAGGTACTTTCAAAACTTATGCTATTAGAATATTTCAAAGACAATGTATTTAAGGAGCTTGGTGAAATGCAATCAAATGAAAAGGGCTTTCCAGAAGAAATTAAACTCATTGAAGATGATAAATGGGAAACAATCGAAAAGCTAAAACTTTGGAAAGATGATGATTGGTTTACAAATTGGATAAAAGTCGAACCAAAACTAGGGGAAACCAATTTGCAGCCATATTTCTATTTTTCGAGAGAGAGCCTTCAATTAAGAAGTTCATCCGAGATTCAACAACTCAGCACTGAAGCTGAAAATATTTTAACTGGACTATTATCAGGGAGTGATTCTTCAAGAACCGAGGCTCTAAAAAAAGCAAACTTGATAAGTGATTTTGAGGCTGCCCAAGTTTTAAAGGCAATTATTTCTGAAATTGAAATAGCATCAGAAATTTCTGCTGATTTATTTAGGTCATTTATTTCTTGGGGTGGTAGTCGGGTCGAAAATTATACCGAAACTATTGTGTGTTTAAATGCAATACCAAGTATTAATATTAAAGCTTCGTTTATTCCTCGAATAAAAGAGTTTGCTTCAGCTTCAAAAAAAACCGTTGAGATTGATGAACTCCTTGAAAAATGGCAAAAAGATAATCCAAGACTAAAAAGTGCTATTGGAAACGAATTAAACTAAAAATATGGGAACTTCTAGCATCTACACCGGGCCTTCCGGAAATCCATTATTACCCGATGATTTTGATGACAATCAAAATTCCGAATCACAACATGATGGTAATTCTCCAGATCAAGAGAACAGCAATGCAGATGGAGAATCTACTAATGATAATCAAAACAATAATAACGATGAAAATCGTGGTGGAGATCAGGAAGCAAATAGTAGTGAAAGCAACTGGAGCAATGCTAAAAATTTTATGTCAAGGTATGCATCAGGTGCATCTATAAACTACAAAAGAGCTGTTTCAAGTTATGTAAAAGCTCATGGAGGTTCAAAAAGTGCAGCAAAATCTGCATCAAGTGGTATTCGTTCGACTTCAGGATTTGGGCAATTTTTAAGTACTAGTTCGACGCAAGGAATTAGAGAAACATTATCTCAATATAATATTGAGTATGAAGGAAGAACCGCGAAAGAAATACTAACAGAAGTATTAAATCGTATCGCTCCAGTACCTGTAACAAAAGAGGATTCTGTTGCGAGGAAAGCTTTACTTCGATCGATGGAAGAATTATATGAAAAACTGGATGATGAAAACAATGACATATCTACTTTAGAAAAGATTGATAAAGGACTTTTAAATGAAATGATTCCGATACAAGTAGAATCATATATTTACGAACGAATTATTAATGACTTAGGTAGTCGTATTGAATCAAAATCAACCTCCCCAGCTGATGCAATAAGTAAGGAGAAAGAGCTAAAAGAATATATCAATTCAAAAGTAGAAACTACCTTAAATGGTAAAGATTTCTCACTAATTGATTTTAATAATACGATGAATAAAGAGGTAGAAAGTCTTTATGTACAATGTTATAAGGTTATGGAGGATTTACTATGAATCAAATTATTTGCAAATTAAATGATGAAGATAATTTTACCGTTCAAGATTGCCTTTTTAATATTAATCTAAATGATAAAAAACAATATCATTGGACATTTTATCAAACAGTAAGAAGGCTGTCTCAGTTTCCAACCTTTTTTTCTGCGGAAGCACTTGATTTATTTTATATTTCTTTGATGGTATACTATGCTGACCGAAAAGTTCTCAGAAAAGATACATTCGACTCGTGGACTCGAAGTTTTAAGATATACATGCCTGTTTTAGAACTTGATAAATGGAATAACCAAAAAGAATTGCTCGAACAAATGGTATCATTTCTGAGTGGTGATTTGTGGGAGTTTGAATTCAGAAAAAGAGAGCTAAATAATAAAGAATTAAGAGTCAAAAAGTGGGCGCAAAAATCAAAGAAAAATTATAAACCCATAGCATTTTGTATGCTTTCAGGCGGATTGGATTCATTTATTGGTGCAATTGATTTATTAAGTAAAGAAAAAGACATCGCTTTTATTGGACATTATGGTGGAGGTAAAGGAGTTATTGAATATCAAAACAATGTCAAAACAATCCTAAGTGAGAAATTTTCTCTTGCCGACAAGCAATTCTTTAATTTTCACGCAGCACCTGTTGGTGGTATTGAAGATTCAACTAGAACACGCTCATTTATGTTCTTTACGCATGCAATAATTTTAGCTTCTGCTTTAAATGAACAAACTAAACTATATATTCCAGAGAATGGCCTAATTTCACTAAACATACCACTTACGAACACTCGATTAGGAACTAGTAGCACTAGGACAACACATCCATATTATATGGGATTGTTACAAACCCTACTAAATAATTTAGAAATCAAAGTTGAATTAGAGAATCCTTACCAATTCAAAACAAAAGGAGAGATGATAATTGAATGTAATGACTCTGCTTTTTTAAAAGAGAATATTACAAAAACAATGTCATGTTCCCACCCGGACCAAGCTCGCTATGATAAGGCAAAAGCTCCTATACACTGTGGTACTTGTTTGCCTTGTGTAATTCGTAGAGCAGCTATTGAGAAGGCTTATGGGAACGATACTTCATCATATAAGAATGTGAATTTCAATCTAGGAAATAATGCTCTAATTGACCTTAGGTCCTACAAAATTGGAATTTTGGATTTTAAAAATTCTTCATCTAAAGCAATATTTAGAATTCAAGAATCGGGTCCTATTTCATATAAGCAAAATGAGTTTGAAAAACTCTATGTACGTGGAATGAATGAACTAGTTCAGCTATTAGATAAATACGATGGATAGTTACTTATACGATACACATTTTCATTTAGATTTATTCAATTCGATTAACGATGTAGTCAAAGAAATTGAAGAAAATAAGATTTACACCATTGCAGTAAGTAATCTACCTGTACTTTATTCCAAGCTAAAGCAAAATATCTCATCTAAATACATAAGACCCGCATTAGGATTTCATCCTGAATTGCTTTTTCAATACAAACATCATATTCCTCAAATGTGGCCATTATTACATGAAGCAAAATACATTGGGGAAGTAGGTTTAGATTTTAAGACAGGAAAAGATTTCAAAGAACTTCAAGTGTCATTCTTTACTGAACTGATCGAACGATGTAACCAGATTGGTGGAAAAATACTTACGATCCATTCTAGACAAAGTGCAGATGAAATTACGTCGATAATAGGCGCCTCGTTTAACGGCAAAGTAATCATGCATTGGTATTCAGGTAATAAAATGACCTTGAAGCAAGCTATTAAAAATGGATATTTCTTTTCTATAAATTACTCGATGGTTAAATCAAATTCTGGGAAAGAATTAATTAAGATGATTCCATTAGATAAATTATTATTAGAAACTGATGCTCCATTTACTAAGTATGACAAGCAACCTTTTACTCCAAAGGATATAAAGTATATAGTCGAAGAATTATCAATTCTTCTTGGTATTGATAATGTTAGAATGTCCTCAATCCTTTGGTCAAACTTTAAGCGATTAATAGCATGAAATGCTAAACATGTAGAGAAGTAAAAGTCTTAACGTCTTTCGCATTCATCGACTCAGATATCCCAGTTTTAATTCAATCTGAGGTTTTCTGTCCTGCGGAACCTTTAGCCAGTGCATTGCTGGCTCTAGTGCAGAAAAAACCTGGTATTTTGAAGAATGTTTATAGCTTCGAACATATTGTACCGCTTTATTCAGAAGTGATTCGGATGCCAGGATGGCAAATTTATTCAAACCTGTATCATCAATATGATCAAATACAAATTGGCTAAGATCCTCAATTTCTGCAAAGTTTAACCCAGTATTTGCTTTTCTAATATCAATTAAGATGGAATATTCCTTTCTAAAAAATGGATTGCTTTTTAAATCAGTAATTACTCTCTCAACACTTTGCTGATCGAGTAAATTATTATGGGAAACAATTATCAATCCTAAACTTTCAATAATATGAAGATTCTCACTTGAAGACAACATTATTTCTTAATTGGTAATACAGGGATTAAAGTAAGCGATTTTTTATAATTGAATCACTGTAATCAGTAATATTAGGTGGAATATTGCCACTAAATCCTGTCAAAGTTACTTCGCCGTCCGGAAAAGTAAAGGGCGGCTGAAATTGCCTATTTTTGCCAGCCGTCCTTCGGAGCTGTTCAGATTTTATTCGATAGACTCCATAAAACGAATTTACTCATGGCCATTAAAAGTAAAACTTCTTTCCTTTTACGGTAGCTAAAGCAACAAAAGACTATTAATTCAACTAATTTGGAGGAAAATTTGTCCTAATTGTTCCAATTTTAGTTTCATTTTTCTACATTTATTGTTCAAAATACAATACTAATCTTTTACCACCATCACTATGGACTTAACTTTAGTTGCACCCAAAGTTGAATTGGTTTACACACCAGCTGTTAATTATGCTATTCAGCAGAATAAAATTCCATTAGTTCGAAAGATTGTAATAGAAAATACCAGCGATAATGACTGGGGAAACTTAACTGTTACTATTGATTCTGATTCTGAATTTGTACGCAAGTGGGAACAGCATATTCAATATCTACCCAAGGGACAGAGTATTGAGTTGAACGTTGATGGAATTAAGCTTTCTGCTAAATATCTTTCAGAATTAACTGAAAAGTTAGCCGGTGAGTTTAGCTTACAATTGTCAGAAAACAATGGCGAAATAATATTTCAGGAGAATTATTCCGTTGACATATTAGCTTATGACCAATGGAATGGTATAGGAGTTTTGCCCGAAATGTTAGCTGCTTTCGTAACTCCAAATCATCCTCAAATTGCCAGGATTCTTTCAAGTGCATCTAAATTCCTAGAGAATTGGACCGGCGACCCTTCTTTTGATGCTTATCAAAGTCTAAATCCTGACCGGGTTCGAAAACAAATGGCTGCAATATATGAGGCAATAGCTGAGCTTGACATTGTTTACTGTTCACCTCCGGCAAGTTTTGAGAGAGAAGGACAGCGAATCAGGTTGTGTGATACTATTTTCTCGCAGAAATTTGCAACCTGCATCGATATGGCACTTTTATATGCCAGTTGTATTGAAGCAGTTGGTTTGAATCCACTCATAATTGTCATTAAAGGTCATGCGTTTGTTGGTAGTTGGCTGATTGATGAGACATTTGCTGATAGTGTTAATGATGACGTTTCATTAATAAAAAAGCGAACAGCATCAGGAATAAACGAAATTGCCCTGGTCGAATCTACGCTCATGAATGCTGGACAAAACCGGTCTTTTGATGATGCAGTGAATAATGCCAATTATAAATTAGTAAATGAAGATAATTTTATTCTTTTCGTTGATATAAAACGGGCACGCTTTGGGCAAATAAAACCTTTACCTCAAAGAATCAAAACGGAAGAAGGTTGGGAAATTGTTGTTGAACCGGAAAAATCAAGGCCAAATTATGTCCCTGACGATATTTTTGTGGACTCATTAAATATACCTGACACTCAAGGATCTCTAACCAAACAGAAATTATGGGAACGTAAACTACTGGATTTGAGTTTGCGGAATAATCTATTAAACCTTCGGGTTACACAAAGTACGATTCAGCTCATTTCGGTTAGTCTTAATCTGTTCGAAGATGCTTTGGCAGATGGAGCCGAATTTCAGGTTTTACCAAAACCGGAGGAATGGGTAAATCCATTAAGTGTCTCTGGAGTTTATCAATCGGTAAACATGGCTGATCCGGTTGTTGGTTTATTAAAAGATGAGCTTGAACATAAACGCTTACGATCTTATCTTACTGACGGAGAACTTTCAAAAGCACTTACTAAACTATATCGAGCCAGCCGATTGTCGCTGGAAGAAAATGGAGCAAACACACTCTACCTTGCTTTAGGATTTTTAAAGTGGTACCAATCAGATAGAAGTGAACTTCCTCGTTATGCTCCGATATTATTGTTACCTATTGAAATCATTCGTAAATCCGCTCAAAAGGGATATGTAATTCGAAGTAGGGAAGAAGAAACGTTAATGAATATAACGCTTCTCGAAATGCTTCGTCAAGATTTCGAGATTGTGATTGGAGGACTGGATGAATTACCAAAAGATGAAAGCGGGGTAGATGTCAAACGTATCTTCAATATTGTCCGTAAAGGCATTATGTCACAACCTAGATGGGACGTTGAGGAACAAGCTTTTCTTGGTACTTTTTCATTCAGTAAGTTTATCATGTGGAATGATATTCACAATAATGCAGATAAGCTTAAGGAAAATAAAATTGTAGAAAGTCTCATTTCCGGAGCTATATCATGGGATGCAGAAGAATCACTTATCGAAGAAATTGATCTTGACCAACAATATTCGCCTTCAGATGTGGCTTTGCCCATTAGTGCAGATTCTTCCCAGTTGGAAGCAATATGCGCTGCTGTTCAGGATAAAAGTTTTATTCTGCATGGACCTCCAGGAACGGGAAAATCGCAAACAATTACAAATATTATTGCAAATGCCCTTTATCAGGGTAAAAGAGTACTTTTTGTGGCCGAGAAGATGGCGGCACTCTCGGTTGTTCAAAAACGGCTGGCAGATATCGGACTCGATCCTTTCTGCCTGGAACTTCATTCCAATAAGTCCAAAAAGTCAGCTGTGCTGGAACAACTTCAAAAGACAACTGAAGTAATTAAGAAGACTTCACCGGAAGAATTTACAATTGAAGCAGAAAGGTTACATTCACTCAGAACGGACCTGAACAATTACGTTGAATCTTTACATAAAAAACATTCGTGTGGATTCTCTTTGTATGACTGTTTTACCGGATATGCACAATTAAACGGAGCTTCTGATCCCATAATGTTTGAAGGCAGGCAAATTCAAGCTTTGTCGGGAGAAATGTTTGAAGAATGGTGTGAAACGATAGAAGAACTTCAGAATGCCGGATCACTGTGTGGGCATCCCCACAACCATCCTTTATCAGAAATCAATACAACCAACTATAGTCAGTCAATCAAGTCGAACTCACTTGATTTGATTAAAGAATACATAGAATTACTAAGTCAATTTAAAGAAAATAGGGAAGCACTGTGTGTGCTATTAAAAATTGATACGCGCATATCTAAGCGAGATCAGGATCAATCAATAAATATTACTGCGGATCTGGTTACAAAATTACCAGATACTCCACAGGAAATTATGACAGTTGGAAATGTTGAAAGTACACTGGAAGAATTGATTGTTCTTGCAGGTCATGGAAGTAAACGAGACGATTATAAAAAATCTTTATTAAAAGACTTCAATAATCAAGTTTTGCTATATAATGCAGAATCCGGATTATCAGCTTGGAATAGGGCATCTGAAAAATGGTTTTTAGCGAAATGGCTCGAACAGAATAAAATAGTAAAGGCATTAAAGACATTTTCTAAGACCGGGAAGTTAAATAAACACGATATTCCTGAATTATTGCAGTTGGTAATTAATTACAGCCGGGAACAAGAAGTATTAAATAATAATTCTGATACGATTAAAAAGTTGCTGGGATTTTTATGGAAGAACGAAACGTGTAACTGGGAAGTCCTGGTTGAAATATGTAAATCGGTAATTGAAATACACAAACAAACAATTTCAATTACTGCCGATCCTCTCAAAGCCAGGCAAATTCGAGAAAATATTGGATCGGGGCTTTCGGATGGAATCAGAACCTATCTACAGATAAATGAAAAAGTCTTTACAAACTATATTGCTACCCAGCAACAGCTAACCCAAATTGAAGACCAAATTCATGAATTGTTAAAAATCAAATTTGGAACAGAGAATAATACTGAACAGGATTGGATTGACATTTGGCAAAATAAAGCAATCTTATGGAAGGAAAATTTGGATTCGCTAAGGGATTGGACTACCTGGAACCTGGCAGTAGAGAAAGCAAGAAAAAGCGAATTATCTCCAATGGTTTCAGCTTATGAAAAAGGAGAACTCCAAAGCAATGAAGTATTAAATTCGTTCAAGAAATCCGTTTATCGTCAATGTTCAGAATTGATCATATCGGCTGATTCTAATCTGTCATCATTTAATGGAAAATTATTTGAAAATAAAATCAGGAAGTTTAAAGAGAAAAGCAAGTACTTTGAGGAACTCACAAAGGCTGAACTTTATGCAACCTTAGCATCGGGTATACCTTCTTTTGCACGAGGAGCAGCAAATAGCTCAGAGATGGGCATCCTTCAACGAGCTATACGAAGTAAAGGCCGGGGAATGTCTGTCCGTCATCTTTTTGATTTGATTCCAAATTTATTGCCTCGTTTGTGTCCTTGTATGTTGATGAGCCCAATTTCTGTAGCTCAGTATTTTGAAGCAGATCTATCAAGATTTGACCTTGTTGTTTTTGACGAAGCATCTCAGATGCCTACTTGCGAAGCTGTTGGAGCAATTGCCAGGGGCAAGAATGTCGTTGTGGTAGGAGATCCTAAACAAATGCCGCCAACAAGTTTCTTTTCAACAAATAAGTTTGATGAAGAAAATGCTGATAAAGAGGATTTGGAAAGTATTCTGGATGATTGTCTTGCTTTGTCTATCCCATCAAAACACCTTTTATGGCATTATAGGAGTAAGCATGAAAGTTTGATAGCATTTAGTAACTCTAATTATTACGATAATAAGTTGATGACTTTTCCTTCGCCTGATGACTTAGCAAGCAAAGTAAGTTATGTGCATGTGCCGGGGTATTATGACCGGGGGAAAACAAGACAGAATAAGTTCGAAGCTTCCGCAATTGTGGAAGAAGTCCTGAAACGATTATCAGATACTTTATTGTCTCAACGAAGTATTGGTATCGTAACATTTAGCTCTACCCAACAAAATCTAATAGAAGACTTGCTCAATGAAGCATTAAAAAATCAACCGGAGCTAGATGCCATTGCGATGGAATCATCTGAACCAATATTTATCAAGAATTTAGAGAATGTGCAGGGGGATGAACGCGATGTGATCCTGTTTTCGATGGGATACGGGCCGGATAAAGATGGCCACGTAACCTTAAATTTCGGACCACTAAACCGTGAAGGAGGATGGAGAAGATTAAATGTTGCAGTTTCCCGGGCACGGTACGAGATGAAAGTTTATTCCACGCTTCGTTCAGATCAGATTGATATAACCAGAACTGCTTCAGAAGGAGTCGCCGGAATTAAAGCCTTCCTGGAGTATTCAGAGAAAGGAAAGATTGTCCTAACTCAGAAAAATTATGAAAGAAAGGCGAAGCATAACTCATTTGAAAAGCTGGTTGCTGAGGAAATTGAAAAAGCAGGATATACTGTTCATACCGATGTCGGCTGTTCAGGTTATCGCATTGATATTGGTGTTGTAAATCCGGAAAATACCTCTGAATATATTTTGGGAATCTTAACGGATGGAAATAATTACCGGTCGGCAACAACAGCAAAAGATCGGGAAGTAGTTCGAATGGATGTACTAAAGCTCTTGGGATGGAACATTTATAAGCTATGGTCCCCTGATTGGTGGGATAATCCCAAAAGAATAGTACAAGAAATTTTGGATGCCATTCAGAGTGCTCTTAATCCGAAAGAATTAATCCCGGAACCAGAAAGACAGACAGAACCTGAATCGAAATACGAAAAATTTGCTGGTGTTAAACTTCAGGGTATAACCCAACAAGTTATTCAACCAGAGACAAAAGAAGATGAAAAGTACTTGGTTTGTGAACTACCTTATACCTCACTAATTGTTTCTGATGAATTTTTTGATACGCGATATACCAATAGAATTCTTGAACAAATTAATAGTGTAATTGAGAGTGAAGCACCCGTAAGCCAAACTTTATTGTCAAGGAGAATATTGAATGCGTGGGGTATTACAAGGCTTGGTGTAAGACTAAATAGTCATCTTCTGTCCCTGTATAAACGACTAAATCTGAAACAAACCCGGCAGAATGGAAGTGTCTTTTATTGGCGACAAGATCAGGAACCTGAGAATTACGACAAATTCAGAGTTCCTGGTGATGATTCAGATAAACGGAATGCTGATGATCTTCCCAAAGAGGAAATCGTAGCAGGTATCAGGGAAATACTTTATAACCAGATAAGTCTGCCGGAAGAAGACCTGGTTCGTGAAACAGCCCGATTATTTGGCTATGCGCGTTTAGGAGGGAATGTGGAACAAGCCATGAAGCTAGGTATTGAATATGCTTTACAGAAAGGAAAAGTAACCAATAACAACGAACGAATAATATTAACCTAACCAAATTTAAAATGAATTTTGTAGCGATTGACGTAGAAACGGCCCAGGGTAGACGATGGAGTATTTGCCAGATTGGGTTGGCTATTGTCGAAAACGGAGAAATTACCCAAACAATTTCACGGCTTGTACAACCTCCCCGGAATGAGTATTCGGAATGGAATATCAGGGTGCATGGAATTACCCCTGACATGACCTCGAATGCACCATTTTTTAAGGATGTTTGGAACGAAATACAACCATTGGTAGAGGGGAATAAACTTGTTGCACACAATTCATCATTCGATATCAATTGTTTGGAACAGACCCTGGATTTTTATGGGCTCCCAATACCAAATATGGAATGTGACTGTACCTACGCCAGAACCGGAGTAAAACTAAACGAAATTTGTGATGCTTTTGAGATTGAATTCACAAACCATCACAATGCTGTCAGTGATGCTGAAGCGTGTGCTAAAGTTTATCTGAAATTATTAAATGGGCTAGAACCTGATTTTTCAAAAATTGCGCCTCGCATACCTAAATCTGGAAATCCCTTCCAGCAGGAAGGACATGAACGGCTTTGTGGTAATGTTCTAAAACCTGATTTGGAAAATGCCGATAGTAATAGTCCGTTTTACGCTAAGAAGGTTGTATTTACAGGTGTGCTGAACACGATTAAAAGAAAAGAGGCTGCTGCCTTGGTCAAAAAGCTCGGAGCAGACATTGATACGTCGATAACTAAACGAACCAACTTTGTCATCACTGGTTCGGCTCCTGGACCTTCCAAAATGAAGAAGATCGAGCAGTTTAATTCTCAGGGATGCGATATCAGGATTATTTATGAAGAGGAGTTTTTGAAGATGTGTAAACATTAATATTACTCTCAACTTAATTTCCATAAATTATGTACATTAACAAAATAATAGTTCAAAATTTCAGGTTACTGAAAAACTCTATACTTGACTTAGAGAATCAAGAGGATAAAGACCTTTCAATCCTTATCGGTAGAAATAACAGCGGTAAAACATCGTTTATAATGCTCTTTGATAAATTTCTAAAAAAATCATCATCGTTCAATTTTGATGATTTTCCGGTATCATTAAGACAGAGCATTTTTGAAATAAATGAAGAAACTGATATTAATGATATTTCAATTAGGCTTATTATTGAAATAACATATACAGATAAAGATAATCTTGAGAATTTATCTGAATTTATTCTTGACCTAAACCCTTCCGAAAATAAAGTACATATACTGTTTGAATGTAGTATTGATAAAAAAAGACTTCTTAAAGAGATTGAAAGTGTTAAACCTGAAAGCCGTAAGCGGTTTATAAAGAAAAATCTGTGTAATTACATAAACACTAATATATATACGTTTGATACATACGATAACTTAAAAGCTGAAAATAGGAATAAGCTTATCGAGAAAGATAAAAAATCCATTGACAACTTAATTAATTACCAGGTTATCCATGCAAAAAGAAGTGTTGCAAGTTCCGAAGCCGGTGAAAGCTCAAAAAAGGTGCTTTCAAATTTGGCTACAAAATACTATGATAAAAAAACAGAGAATCAACTTTCATCAGACGACCTGGATGTAATTAATACTTCACTTCTTGAAATGGATAAAACCCTTGAAGGAAAGTATGAAGAATTCTTTGATAACTTTTTAAACAAATCAAAGGACTTTCTGGCTATGACCGAATTGAGGGTTGTATCAGACTTAGAATCAAAAGAAATTATATCAAATCACTCCAAAATTGTGTATGGTTCAGAAGATGAATCATTGCCTGAGCATTTAAATGGGCTTGGCTACATGAATATTCTTTATTTACTGTTGCAATTAGAGATTAAGAAAGAATTTTTAATAGAAGGCAATAAAGACATTAATCTACTTTTCGTAGAAGAACCTGAAGCTCACACGCATCCACAAATGCAAACAGTCTTTATCGAAAAAGTAAGGACTATTTTAGAAGATATTCCAGCACTACAAACATTTATTACCACTCACTCATCCCACATTGTTAAGAATAGTAATTTCAAGGATATAAGATATTTCTACAATGACCTAGGCAATAGAATTGTAACAATCAAGAACTTTTATACTGAACTCCAAAAGAAATATGAAAAGGAAGAAGATGAATTTAAATTTCTAAATCAATATTTATCTATTGCCTCTGCGGAGTTATTTTTTGCTGAGAAGATAATCTTTATTGAAGGGCTTACGGAAAAACTACTTCTTCCATATTTTATTCAACAATATGATAAGACCAATACTGATGAAGTTTTGCTGTCATCTCAAAACATATCGCTACTAGAAATTGGAGCAAATGCTAAAGCATTTAGCCACTTTATAGATTTCTTAGGCATAAAGGCTTTAATAATAACTGATATTGACACAACAAAGAAAAATGCAAATGGCAGATATAGTGCAGAACCTGTAAAAAATGCAACACATATTAGCAATGCTACTATAAAGCATTTTTATAAAGCTCCCGATTTTAGCCAAATCAAAGAATGGAGTGATTGGTTTATTAATCTGAAAGAGGATAAACATCACAAAGAAGATTCAAATATAAAATTGTCATTTCAGCTTGAGGAAAAAGGTTATCACGGAAGAAGCTTTGAAGAATCTTTTATTAGCATTAATGTAGATAATTTAAAAGCTAATATTTCAGAAGTTAAAGGGCTTAAAGATGATGCAGACGAAAGTCTAAATTCGATTGATGATATAGATGAATTAACGAAAAGCATTTTAGAGAAAAAATCTGATTTTGCCTCGTCATTACTTTGGTTAGCACTCACTAAAGATGTTGATTGGAATATGCCTTCATACATAAAAAAAGGATTAGTATGGATAGCAAAATAACAGCATTAGAGCAAGTATTTAACTGTATAAGGGAAGAGCAAAATTTTGTTCTTCAAGGTGGTGCTGGTAGTGGTAAGACTGAATCCCTTAAACGTGTAATTGAGCATATATCAAAAAACTATCCTGGAAAAAAAATTGCTTGTATTACACATACCAATTTAGCAGTTGATGAAATTAAGTCTAGGGTTGATGATGATTATACCATCTGTACAATTCACTCTTTCTTAAACGACTTAATAAAAGACTACAAGAAAAATCTTCATGAGGTTATTGGTGAAATCTTCAAACTTAAAAAAGTCGATAATGGAGAGCATAAGGATTATAAAAAGTGCTATGAAAAATATGCTTCAACATTGCATTCTGTGTTGAAAGAAACAGTACCAAAGGTAGTTGGTAAAAGAGAGTACGATAAAGAGCCAGATAGATTCTATAATGAATTAAATGCAAATATTGAGAAGCTTAATTCTGAAATAGAAGTTTTAATAAAAGAAATAGATTTCAATGAGGTAAGGTATAATGAAACAAGATTTGACAGCTTTAGAGATTTGTCATTTGGACATGATAGTCTACTTGTAATGGCATCCTTGCTATTTGACAATTATTCTCTGCTCACAAAAATATTACAAGATAAGTACGACTTTATTTTTGTAGACGAGTACCAGGATACCAACAAGGCAATTGTTGATATTTTCCTGAATAAAATTCCTTCAGATAGTAAAACTATAATTGGGCTTTTTGGTGACTCAATGCAGGGTATTTATGATGATGGAATTGGAGATGTTGAAGAATATATTGCAAATGGATTGCTTAAAAAAGTTGAAAAGGAAGATAATTATAGGTGTTCAGAACAGGTTATTGAATTTATAAATCAACTTCGCGATGATGGCTTAAAACAAGAAGTAGCTTTTAAAACAAAGAATGGCGAAGTAGAAACAAAAATAGATAGACAAGGTGCAGTTAAGCTTTATTATTCCATTTATGACGGCTCAAGAACCGCAAGTGGTAATCCTCAGAATAAAGAGGAATATTTACAACATCTAAATTCAGTAATTAAGCATGTTGATGATAACAATTACGGTTATAAAAAGCTAATGCTTACAAATAAGTCCATAGCCAGCGAAGTAGGCTTTGAAAATCTATATAATGTATTTAATGACAGATATGTTGATGTTAAGGAAGAAATTGAAAAAGATTTAACTAGACTTCAACTTTTAGATTTAGCAGAATTATCCAAAGCGTATTCAACAAAGGATTATAATTTCATTATTACAGAACTGAAAAAAGCTGGATTTCTGATAACTACCATTGAAGATAAAAAGAAAATCAGTTCTATTCTTGATAAAATAGTAGCTTCCGAACATGGAGCAATTGAACTTTTGGAACTTGCTTTTGAAAATAGACTTCTTAAAAAGTCGGATTCATATAGTTCATACATTGATAGAAAAGATTCATTTTTGACTGATATTAAGGATGATGAGTTTTATCCTACTTTTAAAACTTATTATGAAGGTGGACAAAACACATTTACCAAGATGGCGAAAGAAGTCGATGGATTAAACGAAGAAGTATTTAAAGAATTCCAAAGGTTATATAAGAAAGAAAGATTCTACAATGATTTGTTTTCTAGTAAGATAAAGTTTAAAGAGATTTTAAACTACTTCTCTTATTTGAATGAAGAAACAAACTACATAACCATGCACAAGACAAAAGGGTCGGGTATTGAAAATGTTATGGTTGTGTTAGATGAATATTTTTGGTATCAGAAGTATAAGTTTAAAACAATCTTTGATGAAAGTGAAATTGACACTACAAAGAGGTTGTACAATCAAAAGTTATTCTATGTAGCATGTTCAAGAGCTATTGATAACCTAATCTGCATTAGACTTATTGCTCCTGATGAAAAAGATGATTTGTTAGGTTATTTTTCGAACTATGAAGAAATAAAAATATAGGATGAATTAGCTTTACTCATAAAAAATTAGAGAAATTAATCAATAATGAAAATACTCCATACATCCGACTGGCATTTAGGTAAACGGCTCGATGATTTTTCCAGACTAGAAGAACAAGAAGCAGTTTTGCAGGAAATTTGTGAAATTGCGGACAATGAACAAGTCGATGCAGTGCTTGTGGCAGGCGATTTGTTTGATACATTTAATCCACCCACCGAAGCAGTAGATTTACTATACAAAACCTTGAAGCGATTAACCAACAACGGTCGCCGTCCGGTTGTTGCTATAGCAGGTAATCACGATTCGCCCGACCGCATTGAGGCACCCGATCCGCTGGCTCGCGAGTGCGGGATAATTTTTGCCGGATATCCAAATTCCCGTATTGCTTCGTTTGAACTGGAATCAGGTATGAAAGTGTTAAACAGCGAAGATGGTTTCCTGGAAGTACAACTCCCGGAAACTCCAGTGCCTTTGCGAATATTACTTACACCTTATGCCAACGAATACCGCCTGAAAACCTGTCTGGAAGTGGAAAACAGCGAAGACGAATTAAGAGCAGTACTTCAGAAAAAGTGGGAAGCACTGGCAGAACAATACTGTGATGATAAGGGAGTAAACGTGCTGGTTTCACATCTTTTTATGGTCAGAAAAGGAGATGAGTTGCCCGAGGAGCCCGAAGATGAAAAACCCATTTTGCATGTGGGTGGAGCGCAGGCGGTTTATACCGAGAATATTCCTGCGAAAATACAGTACACAGCATTGGGGCATCTTCACCGGATGCATCGCGTCGATAATAATTCCAATCCGGTTTACTACAGCGGCAGTCCGCTGTCATACAGTTTTGCCGAGGCCAATCAGAAAAAGTTCGTTTTGTTGGTTGATGCAGACCCCGGGCAGATTGCGGCAGTCAGAAAAATCGAATTAAACAGCGGAAAGCGATTGTTACGCAAACGTGCAGAAGGAATGGAAGACGCTTTGGATTGGTTGTCCGAAAATCAGGAGGCTTTAGTGGAATTAACGCTGGTAACAGAAACTTATCTGAATGCCACTGACCGCAAGCAGTTAAATAAAGCGCATGCCGGAATAGTTTCGATTATCCCCGAAGTAACAAATCCGGATAGTTCGGTTGGTAACCAGCAAAAACAGATTGATTTGAGCCGTAGTATGGAGGAATTGTTCCACGATTATTTTATGCATGAAAAAGGACAGGAACCGAACGATGATTTGAAGAATTTATTTACTGAAATTTTAGCTGAAGAAGAACAATGATACCCGTACAACTCACCATACAAGGTTTGTATTCCTACCAGGAAAAGCAAACCATCGATTTTACAAAACTAACAGCTGCCAATCTGTTTGGGATTTTCGGAACTGTAGGAAGTGGAAAATCCTCAATTCTGGAAGCCATTACTTTTGCCATTTACGGCCGGACTGACCGGTTAAATCTTTCGGGAGACAATCGTTACTACAACATGATGAACCTGAAATCGAATGAGTTACTCATCGATTTTGTATTTGAAACTGGTAAAGAACAAACGGCCTATCGGGCAACGGTTAAGGGCAAGCGTAACGGGAAAAACTTTGAAGATGTAAAAGCGCTGGACCGGTCGGCTTACCGGAAAAAGGGGAACGAGTGGATTCCCATCGCAACGGCTGACCTGGAACAGGCAATTGGTTTAAGTTACGATAATTTTAAACGTACGATTATCATTCCGCAGGGACAGTTTCAGGAGTTTCTGCAATTGGGAAATAAAGACCGGACTCAAATGATGAAGGAACTTTTTAACCTCGGGAAGTTCGAATTTTATTATAAGGTGACCTCGCTCGAAAGCAAAAATAATGCACAAAAGCAGAATATTGAAGGTCAGTTGCAGCAGTTGGGAAGCGTTGATCCTGAACAATTGAAAGTATTCAAATCTCAATTGGTGCAACTTGAGAATGAACTCAAAAAACAGAATGCAAAACTTACTGAATATCAGAAGACAGAAGAAGATCTTCGGAAACTTCAGGACCTGGCAAAACGAAAATCAGAAGCTGAAAAAGCATTCAAATCCTTGCGGGAACAAGAGCCGGTTTTCAAACAATTAGAGCAGAAAATTTCTCGTTTCGAACAGTGTGTAATTCAGTTTAAACATTTGCTGGATGGATTAAAATTGACAAATGAAAAAGTGCAGGTTCGCGAAAAACAGATTAAGCAGGATGAGGTAAAACAAAAGTTGCAGGAGAGCGAAATCGGAACATTGAACAAGAAAATTGAGGAACTAAATCCTGCTTATGAAAAAAGAGAGGAGTTAAAACAAAAGGCAGAAGAACTTGGCCGATTGATACAAATGAAAACACTGGAGCAAACCATTTCAATAGAAAATGGTCGGCTACAGAAAGGAACTCAGGTTTGCAATGATTATGAAAAAAATCTGGAACAATTAAAGATTCAGAAACAAGAGTTGGAGGCGCTGATTAAATTCTCAAAAGGGAAGATGCCCGATCTGGAACTGTTATCCGCGGTGAAAAACTGGTACACCGAGAAACATCTTCTCGAAAAGGAACTTCCGGCAATTCAAAAGGAGTTGGAAGAAAATCAAAAAACAACTTCAAGTCTGCAAAATTCTGTGGCCAAACTATTGGAAGAAGCCGGTCTTACACAACTGCCGGAAATTGAATATTCCAATATCCTTCAAATCTTAAAGGATAAAACGGGAAAAGCAAAGGAAAAGCAGAAAGCACTGAATGAGCAGGAAAGTCATATACGTGTGAAAGAACAGTTGAAAGCTTATTCCGAAAATATGGAAGATGGAGCGCCATGTCCGCTTTGTGGGTCGGTGCATCACCCCGATGTTTTAAAAACCGAAGACCTGAACGACACGTTGTTGAAGCTTAATGTAGAAAAACAGGCAAACGAAAAGGAACAGGAACAGCTATCAGATTGGATAAGCCGCATAAATCTGCTCAGCAAACAGCAAGAGATGATTCATCAGCAGAAAAACTCTTTGTTGCAAAAACAAAAGGCTCAGCAGGAAAGAATTGAGGCTCATGCAAAGAAATTTACCTGGGAGAAATATCGCGTGGAAACCGAACTGGAAAAGGCGTTTCAGGAAGCAAGGCGTATTCAGGGCGAATTGAAAAAGCAGGATGATTTACTGGAGAAGTTAGGGAAGGATATTGATAAGAAAGGGAATGATTTTAAACGGTTTCAGGTGGAAGTCGATAAGATCAGAACCGTTTTAACAGTGCAGCAAACTGAACTAAAAACGCTGGAAAAGCAACTGCGGTTGATAAAAGCCGAAACTTATCAGGAAGTTAAAATTGAACAGATTGAAATAGAAAAAAGTAAGCTGCAGAAGGAACATAGCCAGTTGGAAAAATCTTTTTCCGAAATAACTCAGCAGATAACGGAGAAAAGCAAACTGCGCGACACCTTATTTGGTTCGGTACAGGCCGGCAAAAAGGAACTGGAGCAGGAAAAACAAAGCCTGCACAAGCTGCGACAGCAAACAAAGGAGCAACTGGAAAAATCGACGTATAATTCCATCGATGAGGTTACGGCGATCTTATCGGAATCGTTTAATCCGGATACTGAAAAACAACGTATAGCTCATTTTAAAGATCAGTTTTTGCAAGCAAAGTCGTTATTGCAACAATTGCAGAAAGACGTCGGCGAACGAATCTATGACCAGGAAACACATCAGAAATTAAATGCAGACATTGCTTTGTTAAAGGAACATCTTGCACGGAAGAACCAGGAGCAGGGAAAAATTGCAGAGCAGCTAAAAAAACTACAAAAAGATTTGGAAAGCCAGGCTGCTCTTCAGAAAGAACTAGAAAAGCTGGAGTTGCGGGCAGAGAATCTGAAAACTATAAAATCGTTGTTCAAAGCCAGTGGATTTGTCAACTACATTTCGTCTGTTTACCTGCAAAACTTATGTAATGCAGCTAATGATCGTTTCTTTCAGCTCACCCGGCAAAAGCTGAGTTTAGAAATCACACCCGACAACAATTTCCAGGTGCGCGATTTTATGAATGGTGGAAAGATCAGAAGTGTAAAAACGCTTTCCGGCGGACAGACATTTCAGGCAGCCATGTCGCTGGCTTTAGCGTTGGCCGATAATATCCAGAAAATTACCGAATCGAAACAAAACTTTTTCTTCCTCGACGAAGGATTTGGTTCCCTGGATAAAGAATCGCTGGGAGTTGTTTTTGATACACTAAAATCGTTGCGAAAAGAAAATCGTATTGTTGGTGTTATTTCACATGTTGAAGAAATGCAGCAGGAAATTGATGTTCACCTTCGAATAGATAATCAAGAGGAGCGTGGAAGCCAAATTTGGACAAGTTGGATGGAGTAATCTAATTAAGATTAAGGGAAAATGTTATTTTTTATACATATTTAGCTTTATTAAGCGGATCCTTCATCTATAAAAAAATTGTTACATTGAAAAAACTAAAAGTATTTATATCAAGTGTTCAGAGTGAGTTTGCCAATGAACGGGCAGAGCTGGCAAGTTATCTAAGGCTTGATCCATTACTTGGAACATTTTTCGAACCTTTTATTTTTGAAGAAGTTCCTGCCAATACTCATTCTCCAGGTAAGGTGTATTTGACAGAAGTAAAGGAATCGGATATTTATATGGGGTTATTAGGAACATTATATGGCTTTGAAGATGAAATGGGTGTTTCGCCAACTGAAAGAGAATATGATCAGGCAAAAGCAGAACATATTCCCAGATGGATTTTTATAAAGGACATTGTTGGAGCAGATCGCCATCCCAAAGAAATTGCCTTAATACGGAAAATTGAGCAGGATGTTTCCAGAAAGAAATTTTCCAATCTTGATTTGCTGAAAAAGGAAGTTTATAATTCAGCAGTTCTGTATTTAAAGCAAACAGGAAAAATTGAAAGCCACGATTTTGACGATTCGTTACATCCTTCTGCTGACATCCAATCATTGGATGAAAATAAAGTAAAAGAGTTTGTCGTTCTAGCGAGAAATAAGCGAAACTTTCCCTTAAAAGATACAGCATCAGTTGATCAAGTGTTGAAACATCTAAGAATGATCAAGAATGGAAAGCTCGTAAACAGTGCTTTACTTGCTTTTGCTCCTGATCCTCAATTGTTTTTTCCATCATCAACTATTAAATGCGCTCATTTTCACGGAGTACAAGTGCAGAAACCAATTCCTGATTACAAAGAGTTTGGCGGAACTGTATTTGAGGTAGCAGATGAAGCTGTAAATTTTGTTCTTTCTAAAATAAACTTATCGACTGGTACCAGGGAAAAAAGTAATCAGGTTGAGACTATTTACGAAATTCCTCGTGCTGTTATCTCTGAAGCAATTATTAATGCAGTAGCTCATCGTGATTACTATAGCAAAGGCAGTATACAAGTTTCGATTTTCAGGGATCGAATTGAAGTAACTAATCCTGGTAATTTGCCCCCAGAGTTGGATATTAATGATCTGAGAGAACCACATAGCTCTTATCCTCATAATCCGTTACTCGCAGGTTGTATGTTTTTGACAGGTGAAATTGAACGCTATGGTACGGGAACTCTTGAAATGTTTAAACTCACAGAAGAAAGAGGATTAAGACCACCACTTATTGTTCTTGATGAAGGTTTTAAGGTGACGATTTGGCGACCTTCAGCTGAAGCCATACATGATGCCGAACATGAAGCCATACATGATGCCGAACATGACAACATACATGACGTATCCGAACTATTTTCGGAGATAGTAGAATTGCCCCATCGTTTAGTATTGGTTTTAAAGGGTGAAATGAGCAGGACTCTGCTGATGGAGATTCTTGAATTGAAGAACAGACCGCACTTTGCAACCAATTATCTTGAACCAGCATTAAAAAAAGGGTTAATTGAAATGACTTTGCCTGAAAAGTCAACTAGTAAAAATCAAAAATATCGATTAACCACCAAAGGATTGGGTTTGAAAGAGAAGTTGGAAGGTAAAATGCGGAAATAACAAATCACTAAATGAACAAGTGAGCTAAAATAAGGATGGCTAAATTTGAAAAGATAGAAGATTTGCTTGGCGAGCTATATCGGTACCGAAAGCTTTTTTCCGGAATGTTTGATAAACGGATGTCTCCAATACAGGAAGAAATGGTCGTTTCGTTGGTTGAGCATGATACAGAGAAGCTGGAAAGACTAGCTGCTTTTGACCTTCTATTTCGAAATCAAGGCCTGATTAGCCTTGAACCTCGTTTGCAGGAATTTTTTGAGGAATTTATGGAAGTTGACGAAACGGTTCATGTTCTGTACATCCAGGAGAATCTTGATCAGATTAAGAAAAATCAATCCTATTATTTGAAAGAGAATCAACCCAGCAAACGAGATCAATATCTGGTCAAAATCAAGAAACACTTGTATCGGATTAACCAAACTACGTTACAAAATATAAAGGCACTTCGAGATAATACTGATGAAACCTATAAAACAGAAACAAATTTTGAGATAAAGAAGGAGAAGTTAACGGATATAAGAAATCAAAGAGATGCACTGGAGGGAGTAATTAAAGCCGTTGAAAGGGTATTGCAGGACGATATATTTTTCAAAACAGCGGCTGATACGGAATTGCAGCTTATCGTCCATCGGTTACGACTGGCCTTGAATGACAGCTTCCATAATCTTATTGAAATTCAGCAACAGATTATTGAATACCTAAACCATATCGAAAAACGGGTACATGTTGTTGAAAAAGTTCTACGATTGAAGATGCTTCGGGATAAACACTACCTGAAAGAACGAACCAATTTTTACTGGATCGTCGGATCCAATCAGGATCTTCCTTTACGGAAGACCGAAGGTTTCCGTACCCGACTATCTATTCAGGATATGTTGAATGAGGAAGAAAAACGGAAGCTGATTTTAAAGGTTAGGGAAAAACAGCAAAACCAGCGACTTTTAGCACAGAATACCGCCGGCAGCATATCTGATGAAGCTTTCAATGATAAAAATGAGATAGACAGTGTTTTCAATTATCATGCATTGAAACGGGTCTTCATGGGGAAAAACCAGGACCTTTTTTCTTTTGTCATGCATCATCAGTTTGCTGAGGAAATCTCCATCAACAAACGTATTCAACTATACTGTCGGCTTGCCTCGCTATTCGAAGCGGATTTTGCTTTCTCGGAGGAAACCGGCCGATTTGAAAACCTCGAGTATGCACTTATTTATCCGGCCTCGAATTCAACAACAACCGATCCCCAAACTACTAACACGATAAACGATCCAGCCTAATGAAAGATTCAAACTACAGAACTGCAGAAATATTTGACATCCTGAGTAAAGGGCAATTTATATGCTCTAATGCGATAAATTCACAACGTCGTTATTTGTATCAATATATTGAAGAGAATATTAATGAATTGGAGCCTAAATTCATAGACATTGGATATCAACTGGAAAATGGGAACAACTACTACTATTTCTCACGACCAAATGAAAGCACCCAGAATGTGGAAAACAAGATAGAAAAGGGTTTGCGCTGGCTCGATATTCTGGCATTCTTTACAACTTTTAGAAAGGACTTGTGCCGAGGGGCGCGTTTCAAGCTTTTCGACATTTTGCAACAGATCGATATCAATATGTCGTTGAAAGAACAGTTAACCGATTTACAAAAACGTACAAATCCCGGCAGAAATTACCAGGAGATGCTCAATGATCTGATTCGAGAAGTGCAAAAGGAAGGCTTTATTGATCTTGAAAATGAAATGGATCAAACCTGGAAGATTCTGGATTCATGGGATTACATGGAAAAGTTAGTAATGGCTGTGAATATTCAAGACGAAGAAATTAATAACCAACCACAGGAATTAAACTGAGATGAAACAATTAAGCCGCATTGTGCTGATTAATAGCGCGACTGTTGATTTTTACGAACTTCAACTGGATGGAAATATTCATTTTATTGGAACACAGGGAACAGGCAAAAGTACATTGCTCCGGGCTATTTTGTTTTTTTACAATGCTGATGCCCGCAAGCTGGGAATTTCGAAAGAGAAGTCGTCTTTTAGTGATTACTATTTTCCTTATGCCGATTCCTATATTGTTTACGAGGTGAGTGAGGAAAACCGAAACTTCTGTGTTTGGTTGTATAAAAAACAAAATCGTTTGTGTTTTCGATTCATTGATGGGTCATACAATCGTGAACTTTTTATCTCTCTGCAGCAGGCATTAACAGAAGGGCAGGTGATCGAAAAGGCCAATCAACAGGGATATAAGGTCCACCGACCAATTCATAACTTTACCGAATACCGTGACATTATTTATGGCGCGAACAAGGGAATGAACCGGTTTCATGTACTTCAAAATCCTGGCTATCAAAATATCCCCAGAACGATTTCAAACATCTTTCTGAACTCCTCGCTTGATGGAGGTTTTATCAAAACGACGATTATAAACTCGTTGAGTGATGATCCATTTGAACTGAATCTGGATGCCAACCGGCACCATATTGAGACAGCCAGAAATGATTACCGTGATGTTTCAGAGTATCTCCTACATGAGAAAAAGGCGCAGAATATAGTGACTCAGTATGAAATGCTTCTTCAAATGGAAGATGGAAAGAAGGAGATGGCGTGGCAAATCGGTGCTTCATATAATTTGGCAAAATATAAGGAGCGTGAATTGGAAGATGATCAGAAAGTGATTGGACAAAAGGTACAAGATCAATCCGGTAAAATTGGAAAGATCGAAGCTGAATTTTTGGTGAATCAACGGCGCATCCAAGACAAACTATCCCTTGTAAAAAGGGATATTGCAAAAGCCAATCAATTGGCAAAAAAACTACGCTGCAAAAAATATCCAGCAAATACTGAATGAACATGCTAAAAAGCCAGAATATGAAACAGAACAATCTCAAATAGAAGCACAACTGTCTTTGCTGACTTCAAATTTAAAAGATGTTGAGAGTCAGTATCAGACTGACAAGCAGCGGCTGGAAACACAATGTCAGCAAATCATTCTGGATTTTGAACGTTCCCTGTCCAAAGAGAAGGAAAATCTCCAAAAGGATTCAGCTGATCTGCTTAATACATTCTATAAGAAAAAGGAGCAGATTACAAAAGACCACAACGGTAAGCTGGACGAACAAAAAGAAGATAAAACGATCGTTGACCAGAAGCTACGTGATATTGACCATCAAATTGAAGGCATACAGAAGAAGCCTTTTTTGAAGGAAGAGGTAGAAATGCAAGTTAAGAAACAACAGGAACTTTCGCATAAAAGGCAAGCCCTCGTTTCGGAAAAATTGGTTGCAGGGATAAAGAAGGAAAACGCGATAAAGGAAGGTGAACAAGAATCCGAGGTTTTCGGTCTGAAGAAAAACAAAGAGAATGAGGTCTTGTCTGAAAGGAAGAAATCACTGGAAAAAGAGATAGAACGATTGCAATCGGAACTGCAGGCTTTATCCGGTTCACTTTTAGAGTTTTTGGACCAAAATAACCCAGACTGGCACCAATCAATTGGAAAAGTAATTTCTCGGGATGTTTTGCTAAAGAGTGATTTAAAGCCTTCAATGAAAGATGGAAATAGTATTTATGGTCTGGATATTTCCCTGGATCAACTTCAACCGCTGGAAATCTCAAAATCAAAACTGGAGGAGAAGTTGGACGCTTTCAATAACCTGTTGAAAGAACAAAACAAGCTCGTTGAACAACATCAACAGAAAGCCCAGGATCAGAAAGATAAACTTCAGAAAAAGTACAACAAGAAAATTTCAGAGCTTAGTCAGGAAATCACTCAAAGCGTCATTCAGGTAGATAAGATTGATATTGACCTTGAAAAATGTGGAATCGCTCTGGAAGAATTAAAGGAGAAAGCTGAAAACCTGAAACGTCAGGAATTGATCAAAAAAGACGAAGAAAAGCACACGCTGAAAGTCGAACAACAGAAAATTCTGGATTTTCAAGAAAAGCTACAACAGCAGTTTCAAAATTCCATCCATGAACTTGAATCAATCAAAAGAGGACAAGAGAAAAAGATCAGCAATCGGTTGTTAGAACTAGATGATAAAATAAAATCAGGGAAAAAAGAGATTACAGAAAAATTCAATGTAAAGATCCAAGCTCTGCAGGAACAACGAAACTCGTTTTTGAAAGAAAAAGGGGTGGATACAACAGAAATTCGGCGATTGGAGGATGAGCAAAAAGCCATAAAAAACAAATTATCAGAAATAGAGAAAAGCTTCCCAACAATAATTGAGTACAAAAAAGATTCGGTAGAATACATTGACCGATTGGACGAGTTCCGTCAAAATCGTAAAACTCAGGAAAATGAATTAGAGCATTTGCAGCAACTCCATACCAATAGAATAAATAAGGAGAAAGCTGAACTGAAATTATTACAAAACCAAAAAGAAGAGCTTACCAAAACAATTGGAGAACTACGGCGCGAGTTAAGCGCTTTTGATCTCTTTAGCAAGAGTCATTTGTTTGACGAACTACAAAACTTTATTGAACACCACGATAATGCAGAGAAGTGGGACTGTGATCAAAATATTCGGAAGTTGCAGGAGTTGGCTCTTGAATATGAAAAGCATGATAAACTATTCACAGAGCGGATTACTGAGTTTTCCGGTTATTTCAGTGAACACAATTGTCTTGGATTTGAACCCAGCTTATCCGGCAGATTGCAATATCGGGCCTTTTCTGAAAATTTGAGAGAGTTTGTTCGCGAACAGAAAATTATAGATTATAAAACAGAAGTGACGCGAAAGTATGCGATGGTATTGATGAATATTGTCAATGAAACCAATGAGTTGCTGCAGAAAGAAGAAGATGTTGCAAAAGTGATAAAACGGATCAATACCGATTTTAAGAAATCGAATTTTGTTGGTGTTGTTAAAAGTATTGAAATGCGCCTTCAAGAAAGTTCCGATAAGATTATTCAACTTTTGAGGAAAATAAGGAAATTCCAATCCGAGAACAACCTAAACTACGGAGAAATCAATTTATTCAACCAGGGAGGTTCGAACAGCAATAATGATGAAGCGGTAAAATTGCTGGAAAGCTTACTTTCGCAAATAGGACAGGCGAAGTCAAAGGTTCTGAAACTGGAAGATGCTTTTGACCTGGAATTTAGGATTCGCGAAAACGAGAACGATACAAATTGGGTCAGCCGTCTGGCAAATGTAGGATCAAACGGAACTGATGTTTTGGTCAAGTCAATGATATACATCAATTTGTTGCATATCTTTAAAAGTAATGGTTCCACCCAAAAAATCGATACTATTTTACATTGTTTGATTGATGAAGTAGGAATTCTACACGATAGTAATGTGACAGGGTTAATTACCTTTGCCAGTGAACGAAACATCCGCCTGATTAACGGATCTCCAAATTCACACAATGAGCAGGATTACAAGCATATCTATATGTTTCGAAAGAATCCAAAGTCTAATAAAACAGGAATTACCAAACTGATTAGTCATGAACTCTAAGCCGCTATCCCTGTCATTTGCCCGTTGTTTGATTCGCATGCAGGATGGTGAGCAACTAAATGCAAGTGAGGTTAAGTCAAAAAACTTACTGAAGCGATTTTGTGAGGATGGAATTATTCAAAAGAGGGCTCTAGGTAACCGCAGATCCGGTTATGTTTGTACAAACGCGGAAGTATTACAAAACTATCTTAGGGTACAGAATGGTATACTTTCGTTGGAAAATTATATTGCAGAATTTGAGAATGATACTTCAGATGGGGAGAGTTCGCTTGGGGCATCCAAATCCACCAAAACTTTTCGTGTTAAAAGTTTGCAGGGGTTTTTTATTAAGGCGATAAATTCAGAAATGAGTATTTCTGGAAAAATAATTCAACCGGAGCCTCAAGGCATCGAGTTGTTTGTTCATCAGCCGGAGCACTTGCAAATTTCTAAGACAGCGCTAGTTGTAGGGATTGAAAATCCGGAGTGTTTTCTGAAATTTGAAAAATTGGCTCACCTTTTCCCCCAGCAAGAACTGGTTATAATCATGCGGTATATGAGCAACAGTCCAAACAGGTGGCTTCAAACTATATCAAACAACTATCTGCATTTTGGCGATTTTGATCCGGCAGGTTTGAGTATCTACATCCATGAATACCGGAGGCATTTGCCCAATCATAGATGTGATTATTTTATAACGCCTAATATTGAACAACTAATTAGTCGATATGGACTATCCGACTTATATGATCAGCAGATACATTTGTTAGAGAATATCGATCGCGAACAGTTCCCTGAGATAGATAAACTATTAGATATCCTCGATACACAAAAGAAGGGGCTTGAACAAGAACGCCTGCTGGCTATCGTCTAAGATTACATTATTTACCACTTAATATTCTTAACTCCAGTAGGTTCATTCCATTCATTTGACGCGAAATTCGTACTGGACCTCTGATTATATCATGTCAGGCTAATTTTACCTTCTCCAACTGCTGTTTTCAATTTAAAACCCTTTCTTCATTAGCTCTGTGGATCTTTTGGTTTTAGATCATTTATAATAAAAATGATCTAATAAAAAATATTGCCCTTAAATCCCGTCAAAGTTACTTCGCCGTCCGGAAAAGTCAATGGCGGCTGAAATTTCCCAATTTTGCCAGCCGTCCTTCGGAGCTGTTCAGTTTTTATTTCGCACACTCATAAAAACTGACATAGCCCCTTGACAAGAATCCATCCGGCTCAATGGCATGCGCCAAAATTTAATGGCGTGCCAGAAGCTGCAAAAAATCCCAAGGGCATGGGTGGATTCAATGAGTAAATTTGATATTTATGAAACAGTAACTAATCTTATTGTAGAACGTCTGGAAGCAGGTGTAATACCATGGCATATGCCGTGGAAAACTGCCAGTGCCATTCCTCGTAACCTGGTTTCTAAAAAGCCTTACCGGGGATTTAATTTTTGGTATCTGCTAAGCTTTGGTTTCGAACGTCCTTATTTCCTCACTTTCAAACAGGTTCAGGATCTTGGTGGAAAGATCAAAAAAGGCTCTTCATCATTTATGATTGTATTCTGGAAAATGGTGGAATACGAAAAGGATGATGAAACCAAAGAAATTCCTATGCTTCGTTATTATCGGGTATTTCATATTGATGATGTAGAAGGTATCGATCCTGACAAAATACCTGAGAACACAGCTCACGATCACGACTTCGATCCGATTGCTTCTTGTGAACAGCTTATCCAGTTTTGGTCCGATTCTCCTGTAATAAAACTTGATCAGAAAAAAGCCTGTTATATTCCATCGTTGGATGAAGTACACATGCCTGGTGCAAGAACTTTCTTTCAAGATGAAGAGTTTTACTCTACGATTTTTCATGAATTGTGTCATAATGCTGCATCAGTGATAATGCCGAATTAATTTTATATGCTTGTGTTTTTGAAGGTTTTTAAACTATTCTATCTGCATAATTTTTACAGGACAAGCTTAAATTGAAACAGGTAAACATTGACAATCTTCTCATTTTACCTCATTATATAGCCTACTAACTTAAAATAATGAGTACAATGAATGAACGATTAAAAGCAGAATCAAGAGAAAGACTTAAAGAAGAGTATCAAATTTATCTTAGACGTCAGCGCGGATTAACAGAAAGAACCATCTACAAATACTGCACATTTGCGGATAGATTCTTGAACTTTACGTTTAAGGACGCTCCTGATGATTTATCAAAAATCACAGGGCGTGACATTGTTAGGTTTCTACAATCCTTGACAGGCCATGTGCGGCCATCACCTGATAAAACAATGTCAACCGGAATGCGCAGTTTTTTCCGGTTTCTATTCCAAAGTGAAAAGATTGAGCTCAACCTGGCTGTTGGAATCCCAAGCGTCGCTAATAAATACGCCCATCGAATTCCTTATCATCTGACACCTGAACAGGTGGAGGAATTGCTTGAAGCGGTTCAGACTAGTAGAAAATCAAATTATGCAAAACGTAACTATGCAATGGTTTTACTCATGGCTCGTCTGGGACTGCGGTCACCTGAAGTTATAGCAATACAGCTTAACGACATTGATTGGCGTAGAGGAGAAATCCTCATTCGGGGGAAAGGGAATTACTACGACAAAATACCGTTATTAGAGGACGTTGGGCAAGCGATCGCTGATTATATTCGTGATGAACGGAAAGGTACATCCCGACATGTATTCGTATCAAGTCATTCTCCATACAAACCATTTAAAGATGCCCAGATCTTGAATTCAATTCTGAAGAAGGCTTTGGAGAAAACGAATATTCCAAGACCGAAGCAATATACTGTTAGCTACATTCTCCGGCACAGTCTTGCCACTAACCTTGTTCGAAAAGGAGCAACACTTGAGGAAATAAGTAATACTTTGCGCCATCGTTCACGCCAAACCACTTTGTTATATGCACGTCAGGACATCAACGGCCTAAGGACTATCGCTCAGTCCTGGCCTCTAAGGAAAGGAGGTGCATCATGAGCCTTTCAATGGAGTTGCAGCATTATTTGGAAATACGGAGGAGTCTTGGATATAATTTGAGTACGACAGAGCGCATCCTTAAACGATTCGTTTCTTTTTTGGAAACGAAAAACGAGCATCATATTACGACTGACATGTTTTTACAGTGGAAACATGTCTTTGGGAAGGCATCCCAAAATACCTGGAATAGGCGATTAGGAATGGTTCGGTTGTTTGCAGCCTGGTTAAATAGTTTGGACCCACTTCATGAAATACCACCCCAATCCCTTATTCATTGTCGTTTTCAGCGGAAACCACCATATATCTATACGGATGATGAAATCAAACGGATTATTGAAACAGCCAGCCTTTTACCATCAAGTAATGGATTACGTGAAATCACCTATCCGACATTCTTTGGTCTTGTATCAGTAACCGGGATGAGAATTAGTGAGGCAATTTCTTTGAATAACAGCGATGTGGATCTGCACAACGGCATTATCATGGTGTACAACGGTAAAAATGGAAAAGAACGGATATTGCCTGTTACAGAGTGTACTAAAGTGTATTTAAAAGAATATAGCAGAAAACGTAACAGGCTTTTAGGAAATACACCTGAACCGTTTTTTGTTTCAGATAAAGGCATTCGTTTGACCGATTGTGCTGTCCGATATAATTTTGCAGTTGTTGGTAAGATTATCGGCCTGCGTACCGAACAACAATACCACAAACATGGAATAGGCCCTCGTATTCATGATCTGCGGCATACGTTTGCTGTCAAAATCATGATAAGCTGGTACAAGGAAGGTAAAAATATTGATCAGGAAATGCTGAAACTGGTCACATATTTAGGGCATAAGAATGTCTCACATACCTATTGGTACATTGAAGCTGTCCCGGAATTATTGGCTTTAGCTTCACAGCGTGTTGAAGAATATGTTCGGAAGGAGGTGAAGGTATGACTACATTAACTCTTTCTGCATTAATCCAGAAATATTTTACTGACCGGCTTTACAACCAGCTTGAAGCCAGTCCTCATACAATCTCCAGCTATCGTGACTCATTTAGATTACTTCTAAGGTTTGCCGGAGAGAAGACTATGAAAACACCAACAAAACTAACAGTTAATGATCTCGATGTAGAAATGATTGTGTCTTTTCTGGACGATATTGAGAGACACCGAAAAAACAGTGCAAGGAGCCGAAATACCCGGCTCGCTGCTATCCGTTCTTTCTTTCGTTATGTCGCAATACATGAGCCTGCCTATATGTATCAATGTCAGAAAATTTTGAACCTGCCGGGAAAGCGATATGTAAAACGTAATGTTGAGTTTCTAAACAGTACGGAAATGCAGGCTTTATTAAATGCACCAGACTGCTCAAAATGGATTGGTTGCCGTGATCATACACTGCTCACAATCGCCTTGCAGACAGGATTAAGGGCATCTGAACTTATTAACCTGCGATGTTGTGATGTAGTTCTCGATACTGGAGCACACGTTCGTTGTGAAGGGAAAGGTCGAAAGCATCGTGCAACACCGCTTAGGCGCGAAACAGTCACAGTCATAAAAAATTGGTTAAAGAGACGGGGTAGCTCTGATTTAGAGCCTCTCTTCCCAACTATTAGAGGAGATAAAATGAGCAGGGATGCTCTTGAGCACCTTGTAAAACGGCATGTGAAAACTGCATCGAAATCGTGTCCTTCGCTGATTGGGAAAAGAGTCAGCCCTCATGTTCTACGTCACAGTACTGCAATGGATTTACTTCATCATGGTATTGATCAGACTGTGATTGCTCTTTGGCTCGGCCATGAGTCTATAGAAACGACACAGATTTATATACATGCTGATATGAAGCTAAAAGAAAAAGCTTTGGCAAGAATGTCGAAACCTGAATTAAGTCCAGCTCGCTATAAACCAGATGATGAATTGCTTCGTTTCCTTGAAAATCTATAAAATTATACCGAATGTTCGTACCGGAAGAGTAATCATTACAATCGGTTACAACTCCGGTGCGGCATTATCACGGATGCAACATTATGAACCTTATGCCGATATCGGCATAATGTGCACTCTACGGGTCATCGTAAACGGTTAAATCGTCACGGAAAGTTTTCTAACCTGAACTTCGCCAGTAAAGATTACTCGCAAGATTATCCTAACTAATATATTATCACAACTTTTGAAGCATACCTTTTAGTTTACAGTATGTTAATACCGTAAAAGTTAGGATAATATTTCTTCAAAAAAGTGAGCGGTCTTTGCTAATTCACATGTGTTTATTCCTTAAGGCCAAGATATTCCAGCAGGTCCTTCTTCTTTCGGATGTTTTTCCACTTTTTACCAGTATTCTTCATAACATTATCTTCAAGCGTTGCCAAAGCCTGATTCTTTTGCTCGGTAGAGACAAAAATATAGCGCATTGTCGTATTTATATTAGCATGCCCCATCAATCTTTGGATGGCTACGATATTGAGATGTTGCTCCAGCCAATGACTGGCCCGTGCATGGCGTAGCTGGTGGCAGTGTAAATTCTCGGGCACTTCGGGATTAATACAATGTGCCTTTTGCGCATATATTTTTAGACGCTTATTTACAGCCTCCTGGGTGAGTTTCTTTTTCCTACCGTCATAATAAACGAAGAATAAAAGATCCCAGGGATTAGGTTTTTTGCCGTGGAACATCTCAATGTAACCCTTTAGGACTTTAGAGACCTCTTTAAGTATTGGTGGTGACCTTCTTTTTGCTCCCTTACCCAGGACTGCAATGTAGTTTTTACCATTTGGCTGATTTAAATGGATGTCAGATATTTTTAAGGATAGCACCTCGTCGATACGAGCCCCAATACTGTAAATCAGGTAGAATAGCGTAAAATCACGTTTCCCGATTTTGGTTTTGAGATTGATGACATTAAAAAGAGTTTTAATGGCCTCTTGTGTTATTTCCACCTGTGCCGGCTTGACATATCGCATCTGCTTAACTTCCCGGGCCTCCATCCATAATTGAATAAAGCGGATATCCTTTTTACTCAAGAACTTAAGGAAGTTCTTTAACCCAGCTAGCCGTTGATTACAAGTGGAGTTGGAGCAACTTCTTTCGCTCTTTAACCACAACATCCATTCCTGGATATTAGCAGTTGAAAAAAAATCACCTGAGAGGTTGCCAAAATTGGCTGACTTGGCATCTTTAAGGAAGATAGCGTACAGGGTAATGGCTTTATGATATGACCGCAGAGTATGAGGACTCAGAGCCCTTATTTCAGGAAGATATATCTTCTCCCACTCACGCATTGCCTTTGCGATGACTAAAGATTCAGTTAGTTTCTTCATAATCAAAAAAGTTTGTAAGATTTGGTAACAGTTCATGAAGAGCTTGTCCTGTCAGTTCTTCTAATTGGTTAAAGAACAAAGGAACAAGTTGATAGTAATAACAGGTACTTTCGATTCTTCGATGCCCCATTGAGTGGCTGAGAAAGAGTAGCTTGTCAAACCACTCCGTACCATCATAATCCCAACTATTAATGTTGGTTACAGCGTAAAAGCTACGTAAGTCATAAGCCCGTGCAGGTTCATTGGATATGGTTTTCCAGATATTTCTAAAGTGATTTGAATGCCATGCAATCCCATGGAAGTTATCATTTCTATCTGGAAAGAATATTTTCCTACCTGGCATAAGTCGTTCCATTGCATCATTATATTGTTTTAACAAGTTCCACATGGTTATATGCAAAGCCACTCTGTGTTGATCAAGACCTTTAGTATGGGCAATATTGATTATGCCATTTGTAAGATCAACATCTTTACATTTGAGCATCCGAGCCTCGTTTGTTCTCATACCGGTACTGTAAAGCAACCGGAAGTATACAGGAACTTGCATTCTTCTAAGCTTAAATATCAATTCGTTTTGGCACCCAACAAGCTTAATTGTAGCGGTGGAATGAAAAAAAGCATTTAATTCACCCTGGTTAAATCCATGAGGAGTATATGTGGATTTTTCGTTAGGCAAGTTTTCCGGTATCAACACATTTGTCCATCCATGTTTATTGGTATATTTTAAGAACTTGCGTATCGGCCTTATCCGTAAATTTCGTGATTTGCATTGTTCAAAAGGCCTTTTGCCGCACCATCCATTGACAATATCATCAGTGAGTATATCTGCGTCTGGTTCAATTGATGCGCAGTATTTGTTAAAGCGTATCAGAGTTTTATGAGTAAATCTTGAAAGATGATTTGATGTTTTCAGGTAAAAGATATATTTATCCATCATCCCAGATACGAACGTTTTAACCAAAGGAAGCTCCGTTTCTGAGACAACCTTCTTCGAACTGGAGATTTGAATTAGTGCCGGTAGCATTAAGGACGTATAGCCACAACTGTTAGTGTACCTTAGAAATTGCCGGATACAACCGGCTCGTGCGTTGTGCGAGAGTTCAGTCTCTCCCGGACGTTTAACACACCATTCATCAACCAACTTCTGCGACATATACAGAATCTTCTTTTTATTCACACAGAAACTGGTAAACGTTCTTAACGGCAGGAAGCTCTGATACCCTAATTTCTTTCCTTTAGATCTATGATAGTCCAAATAGGTATCAGTCAGTTCTTCAATTGTTTTCAT

Protein sequences of DBSCAN-SWA_1

>NZ_CP007451|3765973:3822474|3781552_3783484_+|WP_038560568.1|DBSCAN-SWA
MLNESRELQRLHEGFRFFSYLLLFLTLYIDQLVWFREQGLYIPEFSMVLEKILKIEFLSNTLWAKTVCIAFLAITCIGTKAKKDRDLKVSAIVLQVLTGLLMYWGSLLIIVTVPLGYLLLSFFGFVLLNIGFDNISKLINVNLMKDRFNLENESFPQEQGYEENEYSINLETVYQYRNKQHEGWINVINPFRGTIVIGTPGSGKSYSVVLPFIKQHLEKGFCMCVYDFKFSDLSGVAYNHFLKARKNKNLPEQTRFYVINFDDIRKSYRCNPLAPELMESPIDAFESSRTVLYNLNRDWIRKQGEFFSESAVTFFAAVIWFLKKYKNGEYCTLPHAIELLQLEYDDLFEVLSQEKDVVNIINPFINAHKRGANEQLEGQLGSLKIAISKIISKEIYWICSGNDFSLDINNPERPKVVCLANNPLRIEMYGAVLSLFITRMLKVINRKDQQKTSLIFDELPTIYFRGLDTLIATARSNKISTLLGIQTIDQLIRDYGKEQANAILTNIGNAFAGQSVGETARFIQSRMGKILQERQSININRNTQSSTFSTQMDFLVPEGKIATLPQGYMVGQVADNFGQQVGQRNFNCLIDVDTDQIEKEERNYKEIPEVYKIDDLQALLENNRTRICNDIRKILLEISKDSK
>NZ_CP007451|3765973:3822474|3773802_3776217_+|WP_038560544.1|DBSCAN-SWA
MRVKPIQVSLPVLGFDGDILISNNLDMGFGLRLFLPELLSCSTEKLYMLHDTFQRVVNILPENTLLHKQDFFFPEEFSSNSDRALKRRPGLTGNYLSHFYGRRYLKHECYLYVSLLNTGLLKNYLGSSLIFSRKARLEEARLQEKIRELQTNLASIFRQAGIESIPITREQAMGTASEIGLIERYLTLNFREGQPLLGGIDFRDRLRVMDRFVEILSLSDHSHLPSEVRPTSGHPRTGLPVSLVYPLCWHLPYAHITNQFIYVPGQQEVKAGLEGDYKKIYSLSKFSSENKINAGLIENFLDTVQTSGEKIVKTHYNVTLLDTSISNLKKIKSETATAFSLMNCFPYQHTFDLPFLFFAGLPFSTQLPETELFLTQVPQACCLTNYEGAVKNSDSTFTIHLSDRMEGCPVKIDLSDEPMKKNLIHNRNKIIIGGSGSGKSFFTNHLLRQYAESKNCHVVLLDVGRSYEILTRYLDERLKEKGGAKMIEFSETNPISFNPFVVDGSPDLERRQTILSVIYTIYKEQLTEMEKDVIAFSVNRYFETKRKKKRSFNDYYEFCKDIIPRLAREESIEFNSNEFFFILSKYYKGGEYDYLLNKPMQTDEFFSCPFLVFELDAIKDHPVIFPVATLIIMDIFLQKMRKLKRTRKVICLEEAWKAIATPQMADYLKYFFKTIRKFFGEAMVVTQEVDDVISSPIIRDAIINNADTRILLDMGKFKNKFDEISRFLGLNAFQKEQILSINKNLPSNRKFKEVFISLGEYSRVFALEVSRAEYYCYTTEQTEKEQVLEQLIADQSILEILKQM
>NZ_CP007451|3765973:3822474|3769481_3770102_+|WP_038560523.1|DBSCAN-SWA
MFRFNFTESRNWLEDQGKQIFGSHFYIDPLDHPLIHDLLIYAIGDKETAGKRNLDLNKGILLTGPVGCGKTSIMMLIRYFFPPDKKYRIKSTRKISFEFESDGFKVIKRYAPESEVKNTKLRSPNYCFDDLGIEQVQKHFGNECDVMGEILLSRYDLFISEKVMTHITTNLSASEIEQRYGNRVRSRMRAMFNLMAFSKGSEDKRI
>NZ_CP007451|3765973:3822474|3768635_3768932_+|WP_038560516.1|DBSCAN-SWA
MPTEIVTTDDLREFKLELIKEIKQLFAAHHGQPSKKWLKSYEVRKLLGISPGTLQNLRVNGTLAYTKIGGVIFYDSEEIQKMMMENRVQNRFEFGRRK
>NZ_CP007451|3765973:3822474|3814886_3815750_+|WP_139178156.1|DBSCAN-SWA
MNSKPLSLSFARCLIRMQDGEQLNASEVKSKNLLKRFCEDGIIQKRALGNRRSGYVCTNAEVLQNYLRVQNGILSLENYIAEFENDTSDGESSLGASKSTKTFRVKSLQGFFIKAINSEMSISGKIIQPEPQGIELFVHQPEHLQISKTALVVGIENPECFLKFEKLAHLFPQQELVIIMRYMSNSPNRWLQTISNNYLHFGDFDPAGLSIYIHEYRRHLPNHRCDYFITPNIEQLISRYGLSDLYDQQIHLLENIDREQFPEIDKLLDILDTQKKGLEQERLLAIV
>NZ_CP007451|3765973:3822474|3786263_3786485_+|WP_038560583.1|DBSCAN-SWA
MKEIEIKDKQKYLDENYIFEDIPEVSDRKRCLHCGEIIVVGNYKVYANEQGDEYIYCPNAPECDGTIIDWMDV
>NZ_CP007451|3765973:3822474|3773121_3773400_+|WP_139178024.1|DBSCAN-SWA
MAIVAMIVLGVYNTMAQSSAGIDQATTEVNSYVDPVANLIIAIGAVVGLIGGVRVYIKWQSGDQDTQKAIMGWFGACLFLILVGVVIRSFFA
>NZ_CP007451|3765973:3822474|3817876_3818821_+|WP_038560628.1|integrase|DBSCAN-SWA
MSLSMELQHYLEIRRSLGYNLSTTERILKRFVSFLETKNEHHITTDMFLQWKHVFGKASQNTWNRRLGMVRLFAAWLNSLDPLHEIPPQSLIHCRFQRKPPYIYTDDEIKRIIETASLLPSSNGLREITYPTFFGLVSVTGMRISEAISLNNSDVDLHNGIIMVYNGKNGKERILPVTECTKVYLKEYSRKRNRLLGNTPEPFFVSDKGIRLTDCAVRYNFAVVGKIIGLRTEQQYHKHGIGPRIHDLRHTFAVKIMISWYKEGKNIDQEMLKLVTYLGHKNVSHTYWYIEAVPELLALASQRVEEYVRKEVKV
>NZ_CP007451|3765973:3822474|3777632_3778583_+|WP_038560549.1|DBSCAN-SWA
MILQVITTNDFFAFTDTLVDSGVNHARILVDMARAIGGIAAFFYIAKRIYEQLIADNPVSILPLLRPFALVLVITFWGPFVNLLLAPTKGLTHLSEAVYADKKHIVKERLEDKQQSILSTDLPLFYENEEKEADLWDKGVNLILTTYNIFSGRAIQNQINFYIMDATRQLLESFFEVLVYLIAFLRTVFCVLLVIFGPLVFALSIFDGFQDNYLQWIARFINVNLYLPIALLILSIVQEILIYVLEMEIAQINAMLIYEPKLFFVSNLIVPVCGIIGMAMVPKISSWIIHASGTNSGGGRLVRTAAVMAITKGAMK
>NZ_CP007451|3765973:3822474|3770155_3770443_+|WP_038560525.1|DBSCAN-SWA
MRPKKNIIFPKHLQIMERLGENIKLARKRRKLTTVQVAERADIDRTTLYQIEKGNPKVSMGAYFNVLRVLGLQDDFLKLAADDTLGRKLQDLDLL
>NZ_CP007451|3765973:3822474|3799531_3801496_+|WP_038560603.1|DBSCAN-SWA
MYINKIIVQNFRLLKNSILDLENQEDKDLSILIGRNNSGKTSFIMLFDKFLKKSSSFNFDDFPVSLRQSIFEINEETDINDISIRLIIEITYTDKDNLENLSEFILDLNPSENKVHILFECSIDKKRLLKEIESVKPESRKRFIKKNLCNYINTNIYTFDTYDNLKAENRNKLIEKDKKSIDNLINYQVIHAKRSVASSEAGESSKKVLSNLATKYYDKKTENQLSSDDLDVINTSLLEMDKTLEGKYEEFFDNFLNKSKDFLAMTELRVVSDLESKEIISNHSKIVYGSEDESLPEHLNGLGYMNILYLLLQLEIKKEFLIEGNKDINLLFVEEPEAHTHPQMQTVFIEKVRTILEDIPALQTFITTHSSHIVKNSNFKDIRYFYNDLGNRIVTIKNFYTELQKKYEKEEDEFKFLNQYLSIASAELFFAEKIIFIEGLTEKLLLPYFIQQYDKTNTDEVLLSSQNISLLEIGANAKAFSHFIDFLGIKALIITDIDTTKKNANGRYSAEPVKNATHISNATIKHFYKAPDFSQIKEWSDWFINLKEDKHHKEDSNIKLSFQLEEKGYHGRSFEESFISINVDNLKANISEVKGLKDDADESLNSIDDIDELTKSILEKKSDFASSLLWLALTKDVDWNMPSYIKKGLVWIAK
>NZ_CP007451|3765973:3822474|3789925_3791224_+|WP_038560591.1|DBSCAN-SWA
MNQIICKLNDEDNFTVQDCLFNINLNDKKQYHWTFYQTVRRLSQFPTFFSAEALDLFYISLMVYYADRKVLRKDTFDSWTRSFKIYMPVLELDKWNNQKELLEQMVSFLSGDLWEFEFRKRELNNKELRVKKWAQKSKKNYKPIAFCMLSGGLDSFIGAIDLLSKEKDIAFIGHYGGGKGVIEYQNNVKTILSEKFSLADKQFFNFHAAPVGGIEDSTRTRSFMFFTHAIILASALNEQTKLYIPENGLISLNIPLTNTRLGTSSTRTTHPYYMGLLQTLLNNLEIKVELENPYQFKTKGEMIIECNDSAFLKENITKTMSCSHPDQARYDKAKAPIHCGTCLPCVIRRAAIEKAYGNDTSSYKNVNFNLGNNALIDLRSYKIGILDFKNSSSKAIFRIQESGPISYKQNEFEKLYVRGMNELVQLLDKYDG
>NZ_CP007451|3765973:3822474|3816941_3817880_+|WP_038565067.1|integrase|DBSCAN-SWA
MNERLKAESRERLKEEYQIYLRRQRGLTERTIYKYCTFADRFLNFTFKDAPDDLSKITGRDIVRFLQSLTGHVRPSPDKTMSTGMRSFFRFLFQSEKIELNLAVGIPSVANKYAHRIPYHLTPEQVEELLEAVQTSRKSNYAKRNYAMVLLMARLGLRSPEVIAIQLNDIDWRRGEILIRGKGNYYDKIPLLEDVGQAIADYIRDERKGTSRHVFVSSHSPYKPFKDAQILNSILKKALEKTNIPRPKQYTVSYILRHSLATNLVRKGATLEEISNTLRHRSRQTTLLYARQDINGLRTIAQSWPLRKGGAS
>NZ_CP007451|3765973:3822474|3809454_3810696_+|WP_038560613.1|DBSCAN-SWA
MAKFEKIEDLLGELYRYRKLFSGMFDKRMSPIQEEMVVSLVEHDTEKLERLAAFDLLFRNQGLISLEPRLQEFFEEFMEVDETVHVLYIQENLDQIKKNQSYYLKENQPSKRDQYLVKIKKHLYRINQTTLQNIKALRDNTDETYKTETNFEIKKEKLTDIRNQRDALEGVIKAVERVLQDDIFFKTAADTELQLIVHRLRLALNDSFHNLIEIQQQIIEYLNHIEKRVHVVEKVLRLKMLRDKHYLKERTNFYWIVGSNQDLPLRKTEGFRTRLSIQDMLNEEEKRKLILKVREKQQNQRLLAQNTAGSISDEAFNDKNEIDSVFNYHALKRVFMGKNQDLFSFVMHHQFAEEISINKRIQLYCRLASLFEADFAFSEETGRFENLEYALIYPASNSTTTDPQTTNTINDPA
>NZ_CP007451|3765973:3822474|3789053_3789929_+|WP_038560588.1|DBSCAN-SWA
MGTSSIYTGPSGNPLLPDDFDDNQNSESQHDGNSPDQENSNADGESTNDNQNNNNDENRGGDQEANSSESNWSNAKNFMSRYASGASINYKRAVSSYVKAHGGSKSAAKSASSGIRSTSGFGQFLSTSSTQGIRETLSQYNIEYEGRTAKEILTEVLNRIAPVPVTKEDSVARKALLRSMEELYEKLDDENNDISTLEKIDKGLLNEMIPIQVESYIYERIINDLGSRIESKSTSPADAISKEKELKEYINSKVETTLNGKDFSLIDFNNTMNKEVESLYVQCYKVMEDLL
>NZ_CP007451|3765973:3822474|3791990_3792416_-|WP_038560597.1|DBSCAN-SWA
MLSSSENLHIIESLGLIIVSHNNLLDQQSVERVITDLKSNPFFRKEYSILIDIRKANTGLNFAEIEDLSQFVFDHIDDTGLNKFAILASESLLNKAVQYVRSYKHSSKYQVFSALEPAMHWLKVPQDRKPQIELKLGYLSR
>NZ_CP007451|3765973:3822474|3791216_3791945_+|WP_038560594.1|DBSCAN-SWA
MDSYLYDTHFHLDLFNSINDVVKEIEENKIYTIAVSNLPVLYSKLKQNISSKYIRPALGFHPELLFQYKHHIPQMWPLLHEAKYIGEVGLDFKTGKDFKELQVSFFTELIERCNQIGGKILTIHSRQSADEITSIIGASFNGKVIMHWYSGNKMTLKQAIKNGYFFSINYSMVKSNSGKELIKMIPLDKLLLETDAPFTKYDKQPFTPKDIKYIVEELSILLGIDNVRMSSILWSNFKRLIA
>NZ_CP007451|3765973:3822474|3821169_3822474_-|WP_051567936.1|integrase|DBSCAN-SWA
MKTIEELTDTYLDYHRSKGKKLGYQSFLPLRTFTSFCVNKKKILYMSQKLVDEWCVKRPGETELSHNARAGCIRQFLRYTNSCGYTSLMLPALIQISSSKKVVSETELPLVKTFVSGMMDKYIFYLKTSNHLSRFTHKTLIRFNKYCASIEPDADILTDDIVNGWCGKRPFEQCKSRNLRIRPIRKFLKYTNKHGWTNVLIPENLPNEKSTYTPHGFNQGELNAFFHSTATIKLVGCQNELIFKLRRMQVPVYFRLLYSTGMRTNEARMLKCKDVDLTNGIINIAHTKGLDQHRVALHITMWNLLKQYNDAMERLMPGRKIFFPDRNDNFHGIAWHSNHFRNIWKTISNEPARAYDLRSFYAVTNINSWDYDGTEWFDKLLFLSHSMGHRRIESTCYYYQLVPLFFNQLEELTGQALHELLPNLTNFFDYEETN
>NZ_CP007451|3765973:3822474|3773504_3773798_+|WP_038560542.1|DBSCAN-SWA
MKSYTIQKIDTNLYIKGFSGQLVYLALYGILATLILFVILYIAAGTFVSVAVCVPAFFAWLYRLNRIQKNYGHRGWHKKRIARQLPEFITIKQRIYQ
>NZ_CP007451|3765973:3822474|3811281_3812280_+|WP_038560619.1|DBSCAN-SWA
MKQLSRIVLINSATVDFYELQLDGNIHFIGTQGTGKSTLLRAILFFYNADARKLGISKEKSSFSDYYFPYADSYIVYEVSEENRNFCVWLYKKQNRLCFRFIDGSYNRELFISLQQALTEGQVIEKANQQGYKVHRPIHNFTEYRDIIYGANKGMNRFHVLQNPGYQNIPRTISNIFLNSSLDGGFIKTTIINSLSDDPFELNLDANRHHIETARNDYRDVSEYLLHEKKAQNIVTQYEMLLQMEDGKKEMAWQIGASYNLAKYKERELEDDQKVIGQKVQDQSGKIGKIEAEFLVNQRRIQDKLSLVKRDIAKANQLAKKLRCKKYPANTE
>NZ_CP007451|3765973:3822474|3810695_3811280_+|WP_038560616.1|DBSCAN-SWA
MKDSNYRTAEIFDILSKGQFICSNAINSQRRYLYQYIEENINELEPKFIDIGYQLENGNNYYYFSRPNESTQNVENKIEKGLRWLDILAFFTTFRKDLCRGARFKLFDILQQIDINMSLKEQLTDLQKRTNPGRNYQEMLNDLIREVQKEGFIDLENEMDQTWKILDSWDYMEKLVMAVNIQDEEINNQPQELN
>NZ_CP007451|3765973:3822474|3784426_3784804_+|WP_038560574.1|DBSCAN-SWA
MSRYRNPRVKKTEAVRVRFTPLEKKLLRDRCKKEGYKNLSNFFRAKVMRHREIKKIEVSSEFTSLIKRLDFNLNKIGVNLNQVAKQINSKKNNELTATDRHTLDKVQQELKQCFSSLQKYMDIIR
>NZ_CP007451|3765973:3822474|3816138_3816795_+|WP_168136430.1|DBSCAN-SWA
MACQKLQKIPRAWVDSMSKFDIYETVTNLIVERLEAGVIPWHMPWKTASAIPRNLVSKKPYRGFNFWYLLSFGFERPYFLTFKQVQDLGGKIKKGSSSFMIVFWKMVEYEKDDETKEIPMLRYYRVFHIDDVEGIDPDKIPENTAHDHDFDPIASCEQLIQFWSDSPVIKLDQKKACYIPSLDEVHMPGARTFFQDEEFYSTIFHELCHNAASVIMPN
>NZ_CP007451|3765973:3822474|3779258_3779588_+|WP_038560553.1|DBSCAN-SWA
MNNKNNIPNPKDISRFTRWVNELDDKDKTLDPLKRKSKWILITAFLFALFAISFIWFPTGKVKPQKVEAPQAGPVIEAPTNAGHSAFELPVDSFENQLKSYINEENFDK
>NZ_CP007451|3765973:3822474|3768928_3769456_+|WP_038560519.1|DBSCAN-SWA
MNYIKHQTALFERFADDNRITPFHISLYFALFQLWNRNRFRNPFPILREEVMLLAHIGSTNTYAKCIKQLRDWGYIDYTSSGNLYTGWKVSCITFDTGTATRTDTGSATRSNTGTATGTATGSDTRSATVYKEENNTNRTNSTKQDHHKIVKNGKQKKSTGRFHINNDKDYSEPL
>NZ_CP007451|3765973:3822474|3803493_3804717_+|WP_038560605.1|DBSCAN-SWA
MKILHTSDWHLGKRLDDFSRLEEQEAVLQEICEIADNEQVDAVLVAGDLFDTFNPPTEAVDLLYKTLKRLTNNGRRPVVAIAGNHDSPDRIEAPDPLARECGIIFAGYPNSRIASFELESGMKVLNSEDGFLEVQLPETPVPLRILLTPYANEYRLKTCLEVENSEDELRAVLQKKWEALAEQYCDDKGVNVLVSHLFMVRKGDELPEEPEDEKPILHVGGAQAVYTENIPAKIQYTALGHLHRMHRVDNNSNPVYYSGSPLSYSFAEANQKKFVLLVDADPGQIAAVRKIELNSGKRLLRKRAEGMEDALDWLSENQEALVELTLVTETYLNATDRKQLNKAHAGIVSIIPEVTNPDSSVGNQQKQIDLSRSMEELFHDYFMHEKGQEPNDDLKNLFTEILAEEEQ
>NZ_CP007451|3765973:3822474|3804713_3807791_+|WP_038560607.1|DBSCAN-SWA
MIPVQLTIQGLYSYQEKQTIDFTKLTAANLFGIFGTVGSGKSSILEAITFAIYGRTDRLNLSGDNRYYNMMNLKSNELLIDFVFETGKEQTAYRATVKGKRNGKNFEDVKALDRSAYRKKGNEWIPIATADLEQAIGLSYDNFKRTIIIPQGQFQEFLQLGNKDRTQMMKELFNLGKFEFYYKVTSLESKNNAQKQNIEGQLQQLGSVDPEQLKVFKSQLVQLENELKKQNAKLTEYQKTEEDLRKLQDLAKRKSEAEKAFKSLREQEPVFKQLEQKISRFEQCVIQFKHLLDGLKLTNEKVQVREKQIKQDEVKQKLQESEIGTLNKKIEELNPAYEKREELKQKAEELGRLIQMKTLEQTISIENGRLQKGTQVCNDYEKNLEQLKIQKQELEALIKFSKGKMPDLELLSAVKNWYTEKHLLEKELPAIQKELEENQKTTSSLQNSVAKLLEEAGLTQLPEIEYSNILQILKDKTGKAKEKQKALNEQESHIRVKEQLKAYSENMEDGAPCPLCGSVHHPDVLKTEDLNDTLLKLNVEKQANEKEQEQLSDWISRINLLSKQQEMIHQQKNSLLQKQKAQQERIEAHAKKFTWEKYRVETELEKAFQEARRIQGELKKQDDLLEKLGKDIDKKGNDFKRFQVEVDKIRTVLTVQQTELKTLEKQLRLIKAETYQEVKIEQIEIEKSKLQKEHSQLEKSFSEITQQITEKSKLRDTLFGSVQAGKKELEQEKQSLHKLRQQTKEQLEKSTYNSIDEVTAILSESFNPDTEKQRIAHFKDQFLQAKSLLQQLQKDVGERIYDQETHQKLNADIALLKEHLARKNQEQGKIAEQLKKLQKDLESQAALQKELEKLELRAENLKTIKSLFKASGFVNYISSVYLQNLCNAANDRFFQLTRQKLSLEITPDNNFQVRDFMNGGKIRSVKTLSGGQTFQAAMSLALALADNIQKITESKQNFFFLDEGFGSLDKESLGVVFDTLKSLRKENRIVGVISHVEEMQQEIDVHLRIDNQEERGSQIWTSWME
>NZ_CP007451|3765973:3822474|3776238_3776883_+|WP_038560546.1|DBSCAN-SWA
MKNLIVFILIVILAVAASASKAQTPVTDVGAGIQREALWTEEEGILSKINLYNVLIKALNGDIKGLTGEILGIDQKMLESLEKVSLLIKDYKRIKETKDILQQIIAIYTDKVPLLVQDGNFTTQQAAAIVQSFDLILDDSKALVTSILNIIVKDNLFMMDDKQRYDAINGIYLSVKQHYGTICYLHNKLMYASYLKSHDSGDLEGFAMYYSLYH
>NZ_CP007451|3765973:3822474|3778620_3779247_+|WP_038560551.1|DBSCAN-SWA
MQKQFDIQRKFRFIVYVLVLISLSLMGVSSYIYYESVQLVELSKQKIYVLDNGKSLLVALREDISENRDAEARDHVKRFHELFFTLEPDKTYIENNVREALYLADRSAMEQYQAFKENNLYNQVIASDISMTLQTDSIKLDFSAYPYHFTFTGRQKIVRKSNITIRSLKTSGYLRNISRTDNNPHGFLMESWRIDENKDLESIRRKSF
>NZ_CP007451|3765973:3822474|3801480_3803448_+|WP_038565063.1|DBSCAN-SWA
MDSKITALEQVFNCIREEQNFVLQGGAGSGKTESLKRVIEHISKNYPGKKIACITHTNLAVDEIKSRVDDDYTICTIHSFLNDLIKDYKKNLHEVIGEIFKLKKVDNGEHKDYKKCYEKYASTLHSVLKETVPKVVGKREYDKEPDRFYNELNANIEKLNSEIEVLIKEIDFNEVRYNETRFDSFRDLSFGHDSLLVMASLLFDNYSLLTKILQDKYDFIFVDEYQDTNKAIVDIFLNKIPSDSKTIIGLFGDSMQGIYDDGIGDVEEYIANGLLKKVEKEDNYRCSEQVIEFINQLRDDGLKQEVAFKTKNGEVETKIDRQGAVKLYYSIYDGSRTASGNPQNKEEYLQHLNSVIKHVDDNNYGYKKLMLTNKSIASEVGFENLYNVFNDRYVDVKEEIEKDLTRLQLLDLAELSKAYSTKDYNFIITELKKAGFLITTIEDKKKISSILDKIVASEHGAIELLELAFENRLLKKSDSYSSYIDRKDSFLTDIKDDEFYPTFKTYYEGGQNTFTKMAKEVDGLNEEVFKEFQRLYKKERFYNDLFSSKIKFKEILNYFSYLNEETNYITMHKTKGSGIENVMVVLDEYFWYQKYKFKTIFDESEIDTTKRLYNQKLFYVACSRAIDNLICIRLIAPDEKDDLLGYFSNYEEIKI
>NZ_CP007451|3765973:3822474|3768288_3768525_+|WP_038560513.1|DBSCAN-SWA
MATKKNKEFADLIAPFTACPFEKVEVDCPFSDFGNHKGLDEILKLIDQLPDEKLISLREHHKTCQEWKIEKGEAIVNI
>NZ_CP007451|3765973:3822474|3770473_3771724_+|WP_038560528.1|DBSCAN-SWA
MATAKTDIYVYAHWKGLSDPQLIGILSAHAAKGRKAFSFEYTAAWLKSAEYRLLDPDIQFYGGPQFPNNKENFGLFLDSMPDTWGRTLMKRRAAQEAAEKGERAKTLYEVDYLLGVLDESRMGALRFKTDPNGPFLDNNEQSPTPPWSSVAELQEAASNIENETNNDAVKKWLAILIAPGSSLGGARPKANILDKDHNLWIAKFPAKNDTIDKAAWEYLAWQLALKAGINMSECRISKVAGKYNTFFTKRFDREQEQRIHFASAMTMTGNNEDTIRDNPASYLEMAEFIQNHGTRINEHLEQLWRRIVFNIAISNTDDHLRNHGFLLTEKGWVLSPAYDINPSIDKDGLALNIDMDNNALDYELAKSVGPFFRLDNKQMDRIIDEVTTSVKNWRKMAKTIGISNSEQDLMAKAFHI
>NZ_CP007451|3765973:3822474|3779565_3780711_+|WP_038560555.1|DBSCAN-SWA
MKKILINNEALFILPLALLPFVVVIFWVLGGGGVQEEKEKLAQSPNKGINYDLPDADNSIEIYDKMEAYQKEESQVAQVSEVDVNDTTKQEDVSIQDTMDLDNTMLDENASQNEILAHIRNKEKQVQQELQGEPEVRKSGKKTSPQYQIKPIKPVVKKQAETTKSVTPTTGIGELDEIIDENIVLNRRNDSLKYTLQQTQGRLQQIEATQNRSFTLEKKRSSGFNPKETPKQELIKAEIYETTTVLNGNRVKLRLLEDTRINAQKIPRNTFIYGICKIKNERLLIEITQLPVENSFVPVKLTICDMDGMEGLYVPDNAARKVYQEVGASTNTSSLMGVTNNPLTYTGIRAADRAAQTMLKRVRLKKVTVKKNTRIYIINQK
>NZ_CP007451|3765973:3822474|3812215_3814897_+|WP_038560622.1|DBSCAN-SWA
MQKPINWQKNYAAKNIQQILNEHAKKPEYETEQSQIEAQLSLLTSNLKDVESQYQTDKQRLETQCQQIILDFERSLSKEKENLQKDSADLLNTFYKKKEQITKDHNGKLDEQKEDKTIVDQKLRDIDHQIEGIQKKPFLKEEVEMQVKKQQELSHKRQALVSEKLVAGIKKENAIKEGEQESEVFGLKKNKENEVLSERKKSLEKEIERLQSELQALSGSLLEFLDQNNPDWHQSIGKVISRDVLLKSDLKPSMKDGNSIYGLDISLDQLQPLEISKSKLEEKLDAFNNLLKEQNKLVEQHQQKAQDQKDKLQKKYNKKISELSQEITQSVIQVDKIDIDLEKCGIALEELKEKAENLKRQELIKKDEEKHTLKVEQQKILDFQEKLQQQFQNSIHELESIKRGQEKKISNRLLELDDKIKSGKKEITEKFNVKIQALQEQRNSFLKEKGVDTTEIRRLEDEQKAIKNKLSEIEKSFPTIIEYKKDSVEYIDRLDEFRQNRKTQENELEHLQQLHTNRINKEKAELKLLQNQKEELTKTIGELRRELSAFDLFSKSHLFDELQNFIEHHDNAEKWDCDQNIRKLQELALEYEKHDKLFTERITEFSGYFSEHNCLGFEPSLSGRLQYRAFSENLREFVREQKIIDYKTEVTRKYAMVLMNIVNETNELLQKEEDVAKVIKRINTDFKKSNFVGVVKSIEMRLQESSDKIIQLLRKIRKFQSENNLNYGEINLFNQGGSNSNNDEAVKLLESLLSQIGQAKSKVLKLEDAFDLEFRIRENENDTNWVSRLANVGSNGTDVLVKSMIYINLLHIFKSNGSTQKIDTILHCLIDEVGILHDSNVTGLITFASERNIRLINGSPNSHNEQDYKHIYMFRKNPKSNKTGITKLISHEL
>NZ_CP007451|3765973:3822474|3818817_3819813_+|WP_038560630.1|integrase|DBSCAN-SWA
MTTLTLSALIQKYFTDRLYNQLEASPHTISSYRDSFRLLLRFAGEKTMKTPTKLTVNDLDVEMIVSFLDDIERHRKNSARSRNTRLAAIRSFFRYVAIHEPAYMYQCQKILNLPGKRYVKRNVEFLNSTEMQALLNAPDCSKWIGCRDHTLLTIALQTGLRASELINLRCCDVVLDTGAHVRCEGKGRKHRATPLRRETVTVIKNWLKRRGSSDLEPLFPTIRGDKMSRDALEHLVKRHVKTASKSCPSLIGKRVSPHVLRHSTAMDLLHHGIDQTVIALWLGHESIETTQIYIHADMKLKEKALARMSKPELSPARYKPDDELLRFLENL
>NZ_CP007451|3765973:3822474|3784826_3785765_+|WP_038560577.1|DBSCAN-SWA
MVIVMHKSAYTENVMMYNEKKVNEGVATFFHFKNTKSANPFNYDEKHRVKILLDIEDENPRAWHKCFHVSFNPSNEDYKIMNDGTIKQEIDNMMEHMGYGHQPYFVYRHEDLERVHFHVVSTRIDCITHQKIKDNFERLKMQRFLHQLEEKYNLPLKEKPQEINFRFSVRSRNIKENLENLFKHLNEKDELTTKDLYDQALLSFKVEVQKSGRGHIVVVLGDDGKPARYPIRLSKFKNKPKFYSKENRLAEQKTVEKQQLQQQKKPDISEVDLRSVGVVARDLNRLVERSKWHKENPKTKYKTRKKKRGKRF
>NZ_CP007451|3765973:3822474|3765973_3766489_+|WP_139178023.1|transposase|DBSCAN-SWA
MPGKIYTDHKEKLQQISYNHTRKILGGIVNVVFYDVTTIYFQIDDEDEIRKRGFSKEGRHQNPQIVLGLLVGLEGYPLAYEIHEGNKFKGHTILPIIDAFKAKYKLDKLIVITDTGLLSSSNVKELQKKGYEFILGARIKNESTAVKQKILSLKLDDKNWDSSLLFYKRAD
>NZ_CP007451|3765973:3822474|3776896_3777607_+|WP_038560547.1|DBSCAN-SWA
MKRITILLMMVLLILTLTKETKAQIIEIKPWHGYYPEMEGTYPLTFIAFTGWLIPIPHVFVRTWPTHYYVEVGALPVTDGGEIAGELKTGLLRLVAKAIERSQMKGRQEETEGIKVNTDFTQQISDKLFDARSDELNDIYKLAAQFIKLYQKVSKLGSLNNSAQIHSIYEKEADQLLMQFLMVNLFQTDHGRKLDAFSVLSKELWKLLGELDYTHGKLLFFNSFESQPLSYSFLSK
>NZ_CP007451|3765973:3822474|3820136_3821186_-|WP_038560633.1|integrase|DBSCAN-SWA
MKKLTESLVIAKAMREWEKIYLPEIRALSPHTLRSYHKAITLYAIFLKDAKSANFGNLSGDFFSTANIQEWMLWLKSERSCSNSTCNQRLAGLKNFLKFLSKKDIRFIQLWMEAREVKQMRYVKPAQVEITQEAIKTLFNVINLKTKIGKRDFTLFYLIYSIGARIDEVLSLKISDIHLNQPNGKNYIAVLGKGAKRRSPPILKEVSKVLKGYIEMFHGKKPNPWDLLFFVYYDGRKKKLTQEAVNKRLKIYAQKAHCINPEVPENLHCHQLRHARASHWLEQHLNIVAIQRLMGHANINTTMRYIFVSTEQKNQALATLEDNVMKNTGKKWKNIRKKKDLLEYLGLKE
>NZ_CP007451|3765973:3822474|3780716_3781517_+|WP_038560565.1|DBSCAN-SWA
MKQTIFIIVFFLFSLAGYAQNQIEICQNKTTHLIAEEKITYLQVGDPDKLIAEVVPEQPNMVRVKAVDDFEGESSLTVVSANRSYSLFVKYSDANKISYQLEDFIGQIAGNINIGPVPEYLLKELCGQILNDCTQSPIRTRTKKDGIIFRLRNLYLKQDLLFFELEITNSTNIVLDLEAIHWWIDDKKQVKATNVQEYQVEELYRHYNWERIPAKTTLREVVVLPKFIVPDKRILKIELLEKALGNTGRKLTLEVKNKNILKANSF
>NZ_CP007451|3765973:3822474|3787237_3789049_+|WP_038560586.1|DBSCAN-SWA
MWKDSETNVDLLDFDYLIGITKDIIINDELSPSSIGVYGDWGSGKSSLIEMTLSELSKNEDYLCLKFNGWLFEGYEDAKTALIGTILDEINGKKTPAGKAKDVIQRLYKNIDFFKLASKGAKYGLDFLLTGGMGTVADITIQSIISRVKDKASDISEGDIKGVLSKTLKSDEIRKSLKSFHQDFAELLKETKIKRLVIFIDELDRCNPDTILATFEAIRLFLFAEGTSFIIGADERQVMYAVRKKFPETKGNKIDIGKEYLEKIIQYPVKIPQLGIKEVQFYIMCLLLKYELKEKHLPILEFIQKERQKDFLNFSMSFSLIEGKFPREEEKLKEVISLANQLSAVLSKGLNGNPRHCKRFLNSLSMRITMAKIKGIDLDKKVLSKLMLLEYFKDNVFKELGEMQSNEKGFPEEIKLIEDDKWETIEKLKLWKDDDWFTNWIKVEPKLGETNLQPYFYFSRESLQLRSSSEIQQLSTEAENILTGLLSGSDSSRTEALKKANLISDFEAAQVLKAIISEIEIASEISADLFRSFISWGGSRVENYTETIVCLNAIPSINIKASFIPRIKEFASASKKTVEIDELLEKWQKDNPRLKSAIGNELN
>NZ_CP007451|3765973:3822474|3792798_3798648_+|WP_038560600.1|DBSCAN-SWA
MDLTLVAPKVELVYTPAVNYAIQQNKIPLVRKIVIENTSDNDWGNLTVTIDSDSEFVRKWEQHIQYLPKGQSIELNVDGIKLSAKYLSELTEKLAGEFSLQLSENNGEIIFQENYSVDILAYDQWNGIGVLPEMLAAFVTPNHPQIARILSSASKFLENWTGDPSFDAYQSLNPDRVRKQMAAIYEAIAELDIVYCSPPASFEREGQRIRLCDTIFSQKFATCIDMALLYASCIEAVGLNPLIIVIKGHAFVGSWLIDETFADSVNDDVSLIKKRTASGINEIALVESTLMNAGQNRSFDDAVNNANYKLVNEDNFILFVDIKRARFGQIKPLPQRIKTEEGWEIVVEPEKSRPNYVPDDIFVDSLNIPDTQGSLTKQKLWERKLLDLSLRNNLLNLRVTQSTIQLISVSLNLFEDALADGAEFQVLPKPEEWVNPLSVSGVYQSVNMADPVVGLLKDELEHKRLRSYLTDGELSKALTKLYRASRLSLEENGANTLYLALGFLKWYQSDRSELPRYAPILLLPIEIIRKSAQKGYVIRSREEETLMNITLLEMLRQDFEIVIGGLDELPKDESGVDVKRIFNIVRKGIMSQPRWDVEEQAFLGTFSFSKFIMWNDIHNNADKLKENKIVESLISGAISWDAEESLIEEIDLDQQYSPSDVALPISADSSQLEAICAAVQDKSFILHGPPGTGKSQTITNIIANALYQGKRVLFVAEKMAALSVVQKRLADIGLDPFCLELHSNKSKKSAVLEQLQKTTEVIKKTSPEEFTIEAERLHSLRTDLNNYVESLHKKHSCGFSLYDCFTGYAQLNGASDPIMFEGRQIQALSGEMFEEWCETIEELQNAGSLCGHPHNHPLSEINTTNYSQSIKSNSLDLIKEYIELLSQFKENREALCVLLKIDTRISKRDQDQSINITADLVTKLPDTPQEIMTVGNVESTLEELIVLAGHGSKRDDYKKSLLKDFNNQVLLYNAESGLSAWNRASEKWFLAKWLEQNKIVKALKTFSKTGKLNKHDIPELLQLVINYSREQEVLNNNSDTIKKLLGFLWKNETCNWEVLVEICKSVIEIHKQTISITADPLKARQIRENIGSGLSDGIRTYLQINEKVFTNYIATQQQLTQIEDQIHELLKIKFGTENNTEQDWIDIWQNKAILWKENLDSLRDWTTWNLAVEKARKSELSPMVSAYEKGELQSNEVLNSFKKSVYRQCSELIISADSNLSSFNGKLFENKIRKFKEKSKYFEELTKAELYATLASGIPSFARGAANSSEMGILQRAIRSKGRGMSVRHLFDLIPNLLPRLCPCMLMSPISVAQYFEADLSRFDLVVFDEASQMPTCEAVGAIARGKNVVVVGDPKQMPPTSFFSTNKFDEENADKEDLESILDDCLALSIPSKHLLWHYRSKHESLIAFSNSNYYDNKLMTFPSPDDLASKVSYVHVPGYYDRGKTRQNKFEASAIVEEVLKRLSDTLLSQRSIGIVTFSSTQQNLIEDLLNEALKNQPELDAIAMESSEPIFIKNLENVQGDERDVILFSMGYGPDKDGHVTLNFGPLNREGGWRRLNVAVSRARYEMKVYSTLRSDQIDITRTASEGVAGIKAFLEYSEKGKIVLTQKNYERKAKHNSFEKLVAEEIEKAGYTVHTDVGCSGYRIDIGVVNPENTSEYILGILTDGNNYRSATTAKDREVVRMDVLKLLGWNIYKLWSPDWWDNPKRIVQEILDAIQSALNPKELIPEPERQTEPESKYEKFAGVKLQGITQQVIQPETKEDEKYLVCELPYTSLIVSDEFFDTRYTNRILEQINSVIESEAPVSQTLLSRRILNAWGITRLGVRLNSHLLSLYKRLNLKQTRQNGSVFYWRQDQEPENYDKFRVPGDDSDKRNADDLPKEEIVAGIREILYNQISLPEEDLVRETARLFGYARLGGNVEQAMKLGIEYALQKGKVTNNNERIILT
>NZ_CP007451|3765973:3822474|3772704_3773067_+|WP_038560534.1|DBSCAN-SWA
MFGLNEITWKEFIQFLGLLLLLWYTVLLLWSWYKSQKKQNGLFEDDRVAGDTVMTGVQPVVVSASNFPSKLISSISENSIPLEVSVYEETGVNDGIHIDYFLNELTGKLEKLLPEIQYQQ
>NZ_CP007451|3765973:3822474|3767157_3767994_+|WP_168136429.1|DBSCAN-SWA
MEKTVYSNMVDTLEDKLNKLKQENHDVITQAGIAIGLCLITYSELKTIVLKNGFESDKEEINFFKYIKPRLCSKITFYRKQYIIESHRPKSTNTLQIEFLLKEIEKLQLFFEEHHALIEYYRSRQTIFDDKYFKRNITEPLMGTNNYAYLTDPQFSTVYDGILADILAYESLEKYLANEIQKLQHTEGNSGPNDHEYVWTGKLTWLAEMIYGIVETGVINNGNISVNKLIQLFSKIFRLPSEDIYNAYRSVYSRKTEPLIFIEKMREALLKKINDKYK
>NZ_CP007451|3765973:3822474|3807817_3809419_+|WP_081804874.1|DBSCAN-SWA
MFYTYLALLSGSFIYKKIVTLKKLKVFISSVQSEFANERAELASYLRLDPLLGTFFEPFIFEEVPANTHSPGKVYLTEVKESDIYMGLLGTLYGFEDEMGVSPTEREYDQAKAEHIPRWIFIKDIVGADRHPKEIALIRKIEQDVSRKKFSNLDLLKKEVYNSAVLYLKQTGKIESHDFDDSLHPSADIQSLDENKVKEFVVLARNKRNFPLKDTASVDQVLKHLRMIKNGKLVNSALLAFAPDPQLFFPSSTIKCAHFHGVQVQKPIPDYKEFGGTVFEVADEAVNFVLSKINLSTGTREKSNQVETIYEIPRAVISEAIINAVAHRDYYSKGSIQVSIFRDRIEVTNPGNLPPELDINDLREPHSSYPHNPLLAGCMFLTGEIERYGTGTLEMFKLTEERGLRPPLIVLDEGFKVTIWRPSAEAIHDAEHEAIHDAEHDNIHDVSELFSEIVELPHRLVLVLKGEMSRTLLMEILELKNRPHFATNYLEPALKKGLIEMTLPEKSTSKNQKYRLTTKGLGLKEKLEGKMRK
>NZ_CP007451|3765973:3822474|3798659_3799502_+|WP_074780263.1|DBSCAN-SWA
MNFVAIDVETAQGRRWSICQIGLAIVENGEITQTISRLVQPPRNEYSEWNIRVHGITPDMTSNAPFFKDVWNEIQPLVEGNKLVAHNSSFDINCLEQTLDFYGLPIPNMECDCTYARTGVKLNEICDAFEIEFTNHHNAVSDAEACAKVYLKLLNGLEPDFSKIAPRIPKSGNPFQQEGHERLCGNVLKPDLENADSNSPFYAKKVVFTGVLNTIKRKEAAALVKKLGADIDTSITKRTNFVITGSAPGPSKMKKIEQFNSQGCDIRIIYEEEFLKMCKH
>NZ_CP007451|3765973:3822474|3785847_3786231_+|WP_051567932.1|DBSCAN-SWA
MLSDFFRINLPYGIAKNKNNEWMAFNREYLPLGFNSEDIKGLPGLSYLDLPVYTGYENVPDHLLLELADEDHAVQRDKNGEIIRLFLYDDGTNPVNHSERREDLWQKYFCKLQRLSELKRNSIWKYM
>NZ_CP007451|3765973:3822474|3783520_3784201_+|WP_038560571.1|DBSCAN-SWA
MEQSTRIKKEEIPFDKLEKVGVDKEFVNRMEPQELNAFLNGYRSDKLYTVNAKINDQEFRIPAKLRLQKGEDGAVNVKVHPIQRLNIPEKFMGHKFTEEERNALLKEKNLGKTIELKGIDGKKDSYYLAIDPKTNELIPLRASNIKVPGKIKGATLSEEQKQKLAAGKKVFLDKMTGRNGQKFGATLQVDAANRSINFSGFKQEKKLTEEQNEKQTKTKGAKQKVG

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_139178023.1|3765973_3766489_+|transposase	IS1634 family transposase	NA	NA	NA	NA
WP_168136429.1|3767157_3767994_+	RteC domain-containing protein	NA	NA	NA	NA
WP_038560513.1|3768288_3768525_+	hypothetical protein	NA	NA	NA	NA
WP_038560516.1|3768635_3768932_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_038560519.1|3768928_3769456_+	hypothetical protein	NA	NA	NA	NA
WP_038560523.1|3769481_3770102_+	ATPase	NA	NA	NA	NA
WP_038560525.1|3770155_3770443_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_038560528.1|3770473_3771724_+	type II toxin-antitoxin system HipA family toxin	NA	NA	NA	NA
WP_038560534.1|3772704_3773067_+	hypothetical protein	NA	NA	NA	NA
WP_139178024.1|3773121_3773400_+	DUF4134 family protein	NA	NA	NA	NA
WP_038560542.1|3773504_3773798_+	DUF4133 domain-containing protein	NA	NA	NA	NA
WP_038560544.1|3773802_3776217_+	TraG family conjugative transposon ATPase	NA	NA	NA	NA
WP_038560546.1|3776238_3776883_+	hypothetical protein	NA	NA	NA	NA
WP_038560547.1|3776896_3777607_+	hypothetical protein	NA	NA	NA	NA
WP_038560549.1|3777632_3778583_+	hypothetical protein	NA	NA	NA	NA
WP_038560551.1|3778620_3779247_+	conjugative transposon protein TraK	NA	NA	NA	NA
WP_038560553.1|3779258_3779588_+	hypothetical protein	NA	NA	NA	NA
WP_038560555.1|3779565_3780711_+	conjugative transposon protein TraM	NA	NA	NA	NA
WP_038560565.1|3780716_3781517_+	DUF4138 domain-containing protein	NA	NA	NA	NA
WP_038560568.1|3781552_3783484_+	type IV secretory system conjugative DNA transfer family protein	NA	NA	NA	NA
WP_038560571.1|3783520_3784201_+	DUF3945 domain-containing protein	NA	NA	NA	NA
WP_038560574.1|3784426_3784804_+	plasmid mobilization relaxosome protein MobC	NA	NA	NA	NA
WP_038560577.1|3784826_3785765_+	relaxase/mobilization nuclease domain-containing protein	NA	NA	NA	NA
WP_051567932.1|3785847_3786231_+	hypothetical protein	NA	NA	NA	NA
WP_038560583.1|3786263_3786485_+	hypothetical protein	NA	NA	NA	NA
WP_038560586.1|3787237_3789049_+	hypothetical protein	NA	NA	NA	NA
WP_038560588.1|3789053_3789929_+	hypothetical protein	NA	NA	NA	NA
WP_038560591.1|3789925_3791224_+	hypothetical protein	NA	NA	NA	NA
WP_038560594.1|3791216_3791945_+	TatD family hydrolase	NA	NA	NA	NA
WP_038560597.1|3791990_3792416_-	hypothetical protein	NA	NA	NA	NA
WP_038560600.1|3792798_3798648_+	DUF3320 domain-containing protein	NA	NA	NA	NA
WP_074780263.1|3798659_3799502_+	3'-5' exoribonuclease	A0A1S5SEW3	Streptococcus_phage	3.1e-29	30.5
WP_038560603.1|3799531_3801496_+	ATP-dependent endonuclease	NA	NA	NA	NA
WP_038565063.1|3801480_3803448_+	ATP-dependent helicase	NA	NA	NA	NA
WP_038560605.1|3803493_3804717_+	exonuclease subunit SbcD	NA	NA	NA	NA
WP_038560607.1|3804713_3807791_+	SMC family ATPase	G3MAB6	Bacillus_virus	3.6e-06	27.0
WP_081804874.1|3807817_3809419_+	DUF4062 domain-containing protein	NA	NA	NA	NA
WP_038560613.1|3809454_3810696_+	hypothetical protein	NA	NA	NA	NA
WP_038560616.1|3810695_3811280_+	hypothetical protein	NA	NA	NA	NA
WP_038560619.1|3811281_3812280_+	ATP-binding protein	NA	NA	NA	NA
WP_038560622.1|3812215_3814897_+	ATP-binding protein	NA	NA	NA	NA
WP_139178156.1|3814886_3815750_+	hypothetical protein	NA	NA	NA	NA
WP_168136430.1|3816138_3816795_+	DUF1738 domain-containing protein	A0A1V0EEV1	Caulobacter_phage	4.2e-13	26.2
WP_038565067.1|3816941_3817880_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_038560628.1|3817876_3818821_+|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_038560630.1|3818817_3819813_+|integrase	site-specific integrase	U5JA40	Bacillus_phage	1.2e-06	31.7
3820079:3820097	attL	NA	NA	NA	NA
WP_038560633.1|3820136_3821186_-|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_051567936.1|3821169_3822474_-|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
3823763:3823781	attR	NA	NA	NA	NA