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Overview of predicted results

Overview of the results

Contig_ID Contig_def CRISPR array number Contig Signature genes Self targeting spacer number Target MGE spacer number Prophage number Anti-CRISPR protein number
NZ_CP008855 Bacillus sp. X1(2014) strain X1 chromosome, complete genome 2 crisprs RT,DinG,cas3,DEDDh,csa3,cas5,cas8c,cas7,cas4,cas1,cas2 0 10 4 0

Results visualization

1. NZ_CP008855
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CRISPR_ID CRISPR_location CRISPR_type Repeat_type Spacer_info Cas_protein_info CRISPR-Cas_info
NZ_CP008855_1 2706271-2707495 TypeI I-C
18 spacers
cas2,cas1,cas4,cas7,cas8c,cas5,cas3

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CRISPR_ID CRISPR_location CRISPR_type Repeat_type Spacer_info Cas_protein_info CRISPR-Cas_info
NZ_CP008855_2 2708873-2711303 TypeI I-C
36 spacers
cas2,cas1,cas4,cas7,cas8c,cas5,cas3

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CRISPR_ID Spacer_Info Spacer_region Spacer_length Hit_ID Protospacer_location Mismatch Identity
CRISPR_ID Spacer_Info Spacer_region Spacer_length Hit_phage_ID Hit_phage_def Protospacer_location Mismatch Identity
NZ_CP008855_2 2.33|2711038|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2711038-2711072 35 NZ_CP035407 Bacillus subtilis strain SRCM103612 plasmid unnamed1 31204-31238 6 0.829
NZ_CP008855_2 2.6|2709237|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709237-2709271 35 NZ_CP035021 Lactobacillus plantarum strain 13_3 plasmid plsm_LP12_3_pA 1095-1129 7 0.8
NZ_CP008855_2 2.6|2709237|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709237-2709271 35 NZ_CP035021 Lactobacillus plantarum strain 13_3 plasmid plsm_LP12_3_pA 71900-71934 7 0.8
NZ_CP008855_2 2.7|2709304|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709304-2709338 35 NZ_CP035021 Lactobacillus plantarum strain 13_3 plasmid plsm_LP12_3_pA 1095-1129 7 0.8
NZ_CP008855_2 2.7|2709304|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709304-2709338 35 NZ_CP035021 Lactobacillus plantarum strain 13_3 plasmid plsm_LP12_3_pA 71900-71934 7 0.8
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 MK568540 Vibrio phage ValB1 HC, complete genome 3669-3702 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 KP671755 Vibrio phage ValKK3, complete genome 56639-56672 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 MT135026 Vibrio phage V09, complete genome 23716-23749 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 MT612989 Vibrio phage vB_ValM_R11Z, complete genome 23368-23401 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 MT612988 Vibrio phage vB_ValM_R10Z, complete genome 23380-23413 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 NC_021529 Vibrio phage nt-1, complete genome 241208-241241 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 KT919973 Vibrio phage phi-ST2, complete genome 247455-247488 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 MN794232 Vibrio phage VH1_2019, complete genome 75750-75783 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 NC_005083 Vibrio phage KVP40, complete genome 75507-75540 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 JN849462 Vibriophage phi-pp2, complete genome 76873-76906 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 NC_023568 Vibrio phage VH7D, complete genome 10185-10218 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 AY283928 Bacteriophage KVP40, complete genome 75507-75540 8 0.765
NZ_CP008855_1 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706502-2706535 34 MT135025 Vibrio phage V07, complete genome 124357-124390 8 0.765
NZ_CP008855_1 1.11|2706966|35|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706966-2707000 35 NZ_CP048789 Roseobacter ponti strain DSM 106830 plasmid p1, complete sequence 9763-9797 8 0.771
NZ_CP008855_1 1.15|2707231|33|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2707231-2707263 33 NZ_CP023738 Methylosinus trichosporium OB3b plasmid pOB3b1, complete sequence 191579-191611 8 0.758
NZ_CP008855_2 2.4|2709105|34|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709105-2709138 34 NZ_CP035001 Rhizobium acidisoli strain FH23 plasmid pRapFH23c, complete sequence 425909-425942 8 0.765
NZ_CP008855_2 2.6|2709237|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709237-2709271 35 MK327928 Escherichia phage vB_EcoM_G2133, complete genome 163290-163324 8 0.771
NZ_CP008855_2 2.6|2709237|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709237-2709271 35 KT895374 Bacillus phage vB_BpuM-BpSp, complete genome 126777-126811 8 0.771
NZ_CP008855_2 2.7|2709304|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709304-2709338 35 MK327928 Escherichia phage vB_EcoM_G2133, complete genome 163290-163324 8 0.771
NZ_CP008855_2 2.7|2709304|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709304-2709338 35 KT895374 Bacillus phage vB_BpuM-BpSp, complete genome 126777-126811 8 0.771
NZ_CP008855_2 2.26|2710568|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2710568-2710602 35 KT878766 Staphylococcus phage P1105, complete genome 28164-28198 8 0.771
NZ_CP008855_2 2.26|2710568|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2710568-2710602 35 NC_025460 Staphylococcus phage phiSa119, complete genome 3375-3409 8 0.771
NZ_CP008855_1 1.10|2706901|33|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT 2706901-2706933 33 MN850651 Escherichia phage moskry, complete genome 75554-75586 9 0.727
NZ_CP008855_2 2.4|2709105|34|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709105-2709138 34 NZ_CP034999 Rhizobium acidisoli strain FH23 plasmid pRapFH23a, complete sequence 240952-240985 9 0.735
NZ_CP008855_2 2.6|2709237|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709237-2709271 35 MK504443 Lactobacillus phage 521B, complete genome 9114-9148 9 0.743
NZ_CP008855_2 2.7|2709304|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709304-2709338 35 MK504443 Lactobacillus phage 521B, complete genome 9114-9148 9 0.743
NZ_CP008855_2 2.26|2710568|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2710568-2710602 35 NC_007065 Staphylococcus phage X2, complete genome 30113-30147 9 0.743
NZ_CP008855_2 2.26|2710568|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2710568-2710602 35 AY954968 Bacteriophage X2, complete genome 30113-30147 9 0.743
NZ_CP008855_2 2.10|2709503|34|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder 2709503-2709536 34 NZ_CP038854 Pantoea vagans strain LMG 24199 plasmid unnamed1, complete sequence 85050-85083 10 0.706

1. spacer 2.33|2711038|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP035407 (Bacillus subtilis strain SRCM103612 plasmid unnamed1) position: , mismatch: 6, identity: 0.829

accaataactaagaaagtagtacaatgacatcatt-	CRISPR spacer
accaatcgctaagaaagtagtacaatggt-tcatat	Protospacer
****** .*******************.. ****  

2. spacer 2.6|2709237|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP035021 (Lactobacillus plantarum strain 13_3 plasmid plsm_LP12_3_pA) position: , mismatch: 7, identity: 0.8

atcaatccctttcttatttaaaattttttatttcc	CRISPR spacer
ttagttccctttcttattttaatttttttatttct	Protospacer
 * . ************** ** ***********.

3. spacer 2.6|2709237|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP035021 (Lactobacillus plantarum strain 13_3 plasmid plsm_LP12_3_pA) position: , mismatch: 7, identity: 0.8

atcaatccctttcttatttaaaattttttatttcc	CRISPR spacer
ttagttccctttcttattttaatttttttatttct	Protospacer
 * . ************** ** ***********.

4. spacer 2.7|2709304|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP035021 (Lactobacillus plantarum strain 13_3 plasmid plsm_LP12_3_pA) position: , mismatch: 7, identity: 0.8

atcaatccctttcttatttaaaattttttatttcc	CRISPR spacer
ttagttccctttcttattttaatttttttatttct	Protospacer
 * . ************** ** ***********.

5. spacer 2.7|2709304|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP035021 (Lactobacillus plantarum strain 13_3 plasmid plsm_LP12_3_pA) position: , mismatch: 7, identity: 0.8

atcaatccctttcttatttaaaattttttatttcc	CRISPR spacer
ttagttccctttcttattttaatttttttatttct	Protospacer
 * . ************** ** ***********.

6. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to MK568540 (Vibrio phage ValB1 HC, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

7. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to KP671755 (Vibrio phage ValKK3, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

8. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to MT135026 (Vibrio phage V09, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

9. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to MT612989 (Vibrio phage vB_ValM_R11Z, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

10. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to MT612988 (Vibrio phage vB_ValM_R10Z, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

11. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to NC_021529 (Vibrio phage nt-1, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

12. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to KT919973 (Vibrio phage phi-ST2, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

13. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to MN794232 (Vibrio phage VH1_2019, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

14. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to NC_005083 (Vibrio phage KVP40, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

15. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to JN849462 (Vibriophage phi-pp2, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

16. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to NC_023568 (Vibrio phage VH7D, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

17. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to AY283928 (Bacteriophage KVP40, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

18. spacer 1.4|2706502|34|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to MT135025 (Vibrio phage V07, complete genome) position: , mismatch: 8, identity: 0.765

cctcctatttgttgatcgctgatatatgggcatt	CRISPR spacer
actcctatttgttgatcgctgttttatcagcgca	Protospacer
 ******************** * *** .**.. 

19. spacer 1.11|2706966|35|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP048789 (Roseobacter ponti strain DSM 106830 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.771

acgccgtccggccattcgacctgccgcaacgctac	CRISPR spacer
aggcctgagagccattcgacctgccacaacgccac	Protospacer
* ***    .***************.******.**

20. spacer 1.15|2707231|33|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023738 (Methylosinus trichosporium OB3b plasmid pOB3b1, complete sequence) position: , mismatch: 8, identity: 0.758

atcagtctcgcccgcctgagtgattgcaaaaat	CRISPR spacer
atcgacctcgcccgcgtgagcgattgcaaattg	Protospacer
***...********* ****.*********   

21. spacer 2.4|2709105|34|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP035001 (Rhizobium acidisoli strain FH23 plasmid pRapFH23c, complete sequence) position: , mismatch: 8, identity: 0.765

ctgcaaatggtgccgaccaatcagacggaaaact	CRISPR spacer
ccgccgatggtgccgaccaatcggccggaacgcg	Protospacer
*.** .****************.* ***** .* 

22. spacer 2.6|2709237|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to MK327928 (Escherichia phage vB_EcoM_G2133, complete genome) position: , mismatch: 8, identity: 0.771

atcaatccctttcttatttaaaattttttatttcc	CRISPR spacer
ggctctcccttttttatttaaaatttttttttcac	Protospacer
. *  *******.**************** **. *

23. spacer 2.6|2709237|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to KT895374 (Bacillus phage vB_BpuM-BpSp, complete genome) position: , mismatch: 8, identity: 0.771

--atcaatccctttcttatttaaaattttttatttcc	CRISPR spacer
ggtttaa--actttcatatttaaaagtttttatttca	Protospacer
   *.**   ***** ********* ********** 

24. spacer 2.7|2709304|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to MK327928 (Escherichia phage vB_EcoM_G2133, complete genome) position: , mismatch: 8, identity: 0.771

atcaatccctttcttatttaaaattttttatttcc	CRISPR spacer
ggctctcccttttttatttaaaatttttttttcac	Protospacer
. *  *******.**************** **. *

25. spacer 2.7|2709304|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to KT895374 (Bacillus phage vB_BpuM-BpSp, complete genome) position: , mismatch: 8, identity: 0.771

--atcaatccctttcttatttaaaattttttatttcc	CRISPR spacer
ggtttaa--actttcatatttaaaagtttttatttca	Protospacer
   *.**   ***** ********* ********** 

26. spacer 2.26|2710568|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to KT878766 (Staphylococcus phage P1105, complete genome) position: , mismatch: 8, identity: 0.771

ataaattggaaaagtttttttatagtaaaaccaac	CRISPR spacer
gttaattggaaaagttattttatagttaaaggaga	Protospacer
.* ************* ********* ***  *. 

27. spacer 2.26|2710568|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to NC_025460 (Staphylococcus phage phiSa119, complete genome) position: , mismatch: 8, identity: 0.771

ataaattggaaaagtttttttatagtaaaaccaac	CRISPR spacer
gttaattggaaaagttattttatagttaaaggaga	Protospacer
.* ************* ********* ***  *. 

28. spacer 1.10|2706901|33|NZ_CP008855|PILER-CR,CRISPRCasFinder,CRT matches to MN850651 (Escherichia phage moskry, complete genome) position: , mismatch: 9, identity: 0.727

cccacatatcatcaccgtcctataagtaataaa	CRISPR spacer
taaggtgatcaccaccctcctataagtaataaa	Protospacer
.  .   ****.**** ****************

29. spacer 2.4|2709105|34|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP034999 (Rhizobium acidisoli strain FH23 plasmid pRapFH23a, complete sequence) position: , mismatch: 9, identity: 0.735

ctgcaaatggtgccgaccaatcagacggaaaact	CRISPR spacer
ccgccgatggtgccgaccaatcggccggaacggg	Protospacer
*.** .****************.* ***** .  

30. spacer 2.6|2709237|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to MK504443 (Lactobacillus phage 521B, complete genome) position: , mismatch: 9, identity: 0.743

atcaatccctttcttatttaaaattttttatttcc	CRISPR spacer
tttaatccctttcttatttagaatttctttgattt	Protospacer
 *.*****************.*****.**   *..

31. spacer 2.7|2709304|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to MK504443 (Lactobacillus phage 521B, complete genome) position: , mismatch: 9, identity: 0.743

atcaatccctttcttatttaaaattttttatttcc	CRISPR spacer
tttaatccctttcttatttagaatttctttgattt	Protospacer
 *.*****************.*****.**   *..

32. spacer 2.26|2710568|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to NC_007065 (Staphylococcus phage X2, complete genome) position: , mismatch: 9, identity: 0.743

ataaattggaaaagtttttttatagtaaaaccaac	CRISPR spacer
gttagttggaaaagttattttatagttaaaggaga	Protospacer
.* *.*********** ********* ***  *. 

33. spacer 2.26|2710568|35|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to AY954968 (Bacteriophage X2, complete genome) position: , mismatch: 9, identity: 0.743

ataaattggaaaagtttttttatagtaaaaccaac	CRISPR spacer
gttagttggaaaagttattttatagttaaaggaga	Protospacer
.* *.*********** ********* ***  *. 

34. spacer 2.10|2709503|34|NZ_CP008855|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP038854 (Pantoea vagans strain LMG 24199 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.706

ttacgtacaacttcgattacaaacgtttcatcac	CRISPR spacer
ttacgtacaagttcgattaaaaacagacgctggc	Protospacer
********** ******** ****.  .  * .*

Region Region Position Protein_number Hit_taxonomy Key_proteins Att_site Prophage annotation
DBSCAN-SWA_1 5696 : 15109 10 Staphylococcus_phage(50.0%) NA NA
DBSCAN-SWA_2 1630415 : 1674661 39 Bacillus_phage(40.0%) transposase,protease NA
DBSCAN-SWA_3 2230571 : 2240477 9 Synechococcus_phage(42.86%) NA NA
DBSCAN-SWA_4 2749047 : 2805743 55 Bacillus_phage(33.33%) transposase,integrase,tRNA attL 2782138:2782195|attR 2793468:2793525
Acr ID Acr position Acr size Homology with known anti Neighbor HTH/AcRanker Neighbor Aca In prophage Protospacer in prophage