CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP009278	Sphingobacterium sp. ML3W chromosome, complete genome	5 crisprs	cas3,WYL,c2c10_CAS-V-U3,PD-DExK,DEDDh,csa3,RT,DinG	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP009278_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009278_1

1210928-1211034

Orphan

Consensus_repeat	Method
GATAATCATCCATACTTATCTATAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009278_1

>merge|NZ_CP009278|1|1210928-1211034|CRISPRCasFinder
GATAATCATCCATACTTATCTATAGTAGAACAATAAGTATCTATACTATATATAAGGAGCGATTGAACATTCTGTTCTATTGATAATCATCCATACTTATCTATAGT

>NZ_CP009278|1|1|1210928-1211034|CRISPRCasFinder
GATAATCATCCATACTTATCTATAGT	AGAACAATAAGTATCTATACTATATATAAGGAGCGATTGAACATTCTGTTCTATT
GATAATCATCCATACTTATCTATAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009278.1\|WP_038702164.1\|1229148_1230624_+\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|234967
NZ_CP009278.1\|WP_038696436.1\|1200806_1202183_+\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236430
NZ_CP009278.1\|WP_144243398.1\|1204801_1205677_-\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|224394
NZ_CP009278.1\|WP_038696451.1\|1217319_1219458_+\|cytochrome-c-oxidase,-cbb3-type-subunit-I	unknown	unknown	gnl\|CDD\|184703
NZ_CP009278.1\|WP_038696447.1\|1207980_1208466_-\|DUF2271-domain-containing-protein	unknown	unknown	gnl\|CDD\|378361
NZ_CP009278.1\|WP_038696434.1\|1200388_1200802_+\|lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|240659
NZ_CP009278.1\|WP_038696430.1\|1197933_1199124_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP009278.1\|WP_038696445.1\|1205790_1207974_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|99798
NZ_CP009278.1\|WP_038696432.1\|1199130_1200192_+\|response-regulator	unknown	unknown	gnl\|CDD\|381104
NZ_CP009278.1\|WP_038696467.1\|1227730_1228891_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP009278.1\|WP_038696449.1\|1208470_1209979_-\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|222980
NZ_CP009278.1\|WP_038696459.1\|1221961_1222384_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377555
NZ_CP009278.1\|WP_038696465.1\|1224540_1227696_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP009278.1\|WP_038696455.1\|1219666_1220536_+\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|129864
NZ_CP009278.1\|WP_038696463.1\|1223076_1224531_-\|efflux-transporter-outer-membrane-subunit	unknown	unknown	gnl\|CDD\|273830
NZ_CP009278.1\|WP_038696453.1\|1219472_1219664_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038696461.1\|1222385_1223084_+\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|372587
NZ_CP009278.1\|WP_038696438.1\|1202192_1204580_+\|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl\|CDD\|319851
NZ_CP009278.1\|WP_038696441.1\|1204605_1204782_+\|cbb3-type-cytochrome-oxidase-assembly-protein-CcoS	unknown	unknown	gnl\|CDD\|377073
NZ_CP009278.1\|WP_038696457.1\|1220547_1221930_+\|cytochrome-c-oxidase-accessory-protein-CcoG	unknown	unknown	gnl\|CDD\|274278

Protein	Function_ID	Function_description	E-value
NZ_CP009278.1\|WP_038702164.1\|1229148_1230624_+\|cardiolipin-synthase	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	8.83658e-128
NZ_CP009278.1\|WP_038696436.1\|1200806_1202183_+\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236430	PRK09249, PRK09249, coproporphyrinogen dehydrogenase.	0
NZ_CP009278.1\|WP_144243398.1\|1204801_1205677_-\|FAD:protein-FMN-transferase	gnl\|CDD\|224394	COG1477, ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism].	1.52731e-90
NZ_CP009278.1\|WP_038696451.1\|1217319_1219458_+\|cytochrome-c-oxidase,-cbb3-type-subunit-I	gnl\|CDD\|184703	PRK14485, PRK14485, putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional.	0
NZ_CP009278.1\|WP_038696447.1\|1207980_1208466_-\|DUF2271-domain-containing-protein	gnl\|CDD\|378361	pfam10029, DUF2271, Predicted periplasmic protein (DUF2271). This domain, found in various hypothetical bacterial proteins and misannotated lysozyme proteins, it has no known function.	2.59375e-43
NZ_CP009278.1\|WP_038696434.1\|1200388_1200802_+\|lactate-dehydrogenase	gnl\|CDD\|240659	cd12183, LDH_like_2, D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains. D-Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate, and is a member of the 2-hydroxyacid dehydrogenase family. LDH is homologous to D-2-hydroxyisocaproic acid dehydrogenase (D-HicDH) and shares the 2-domain structure of formate dehydrogenase. D-2-hydroxyisocaproate dehydrogenase-like (HicDH) proteins are NAD-dependent members of the hydroxycarboxylate dehydrogenase family, and share the Rossmann fold typical of many NAD binding proteins. HicDH from Lactobacillus casei forms a monomer and catalyzes the reaction R-CO-COO(-) + NADH + H+ to R-COH-COO(-) + NAD+. D-HicDH, like the structurally distinct L-HicDH, exhibits low side-chain R specificity, accepting a wide range of 2-oxocarboxylic acid side chains. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain.	1.70179e-20
NZ_CP009278.1\|WP_038696430.1\|1197933_1199124_+\|PAS-domain-S-box-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.47495e-44
NZ_CP009278.1\|WP_038696445.1\|1205790_1207974_-\|FAD-binding-oxidoreductase	gnl\|CDD\|99798	cd06201, SiR_like2, Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ gene) are of the cytochrome p450 (CyPor) family having FAD and FMN as prosthetic groups and utilizing NADPH. Cypor (including cyt -450 reductase, nitric oxide synthase, and methionine synthase reductase) are ferredoxin reductase (FNR)-like proteins with an additional N-terminal FMN domain and a connecting sub-domain inserted within the flavin binding portion of the FNR-like domain. The connecting domain orients the N-terminal FMN domain with the C-terminal FNR domain. NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via FAD and FMN. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	2.95831e-61
NZ_CP009278.1\|WP_038696432.1\|1199130_1200192_+\|response-regulator	gnl\|CDD\|381104	cd17552, REC_RR468-like, phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains. Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	7.18075e-35
NZ_CP009278.1\|WP_038696467.1\|1227730_1228891_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	9.17611e-64
NZ_CP009278.1\|WP_038696449.1\|1208470_1209979_-\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|222980	PHA03095, PHA03095, ankyrin-like protein; Provisional.	4.86372e-18
NZ_CP009278.1\|WP_038696459.1\|1221961_1222384_+\|hypothetical-protein	gnl\|CDD\|377555	pfam05751, FixH, FixH. This family consists of several Rhizobium FixH like proteins. It has been suggested that suggested that the four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG.	7.0291e-21
NZ_CP009278.1\|WP_038696465.1\|1224540_1227696_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP009278.1\|WP_038696455.1\|1219666_1220536_+\|c-type-cytochrome	gnl\|CDD\|129864	TIGR00782, di-heme_cytochrome_cp, cytochrome c oxidase, cbb3-type, subunit III. This model describes a di-heme subunit of approximately 26 kDa of the cbb3 type copper and heme-containing cytochrome oxidase. [Energy metabolism, Electron transport].	1.26673e-28
NZ_CP009278.1\|WP_038696463.1\|1223076_1224531_-\|efflux-transporter-outer-membrane-subunit	gnl\|CDD\|273830	TIGR01845, Outer_membrane_protein_OprM, efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family. Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins].	5.22771e-69
NZ_CP009278.1\|WP_038696457.1\|1220547_1221930_+\|cytochrome-c-oxidase-accessory-protein-CcoG	gnl\|CDD\|274278	TIGR02745, iron-sulfur_cluster-binding_protein, cytochrome c oxidase accessory protein FixG. Member of this ferredoxin-like protein family are found exclusively in species with an operon encoding the cbb3 type of cytochrome c oxidase (cco-cbb3), and near the cco-cbb3 operon in about half the cases. The cco-cbb3 is found in a variety of proteobacteria and almost nowhere else, and is associated with oxygen use under microaerobic conditions. Some (but not all) of these proteobacteria are also nitrogen-fixing, hence the gene symbol fixG. FixG was shown essential for functional cco-cbb3 expression in Bradyrhizobium japonicum.	6.69834e-127
NZ_CP009278.1\|WP_038696461.1\|1222385_1223084_+\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|372587	pfam13386, DsbD_2, Cytochrome C biogenesis protein transmembrane region.	2.61554e-34
NZ_CP009278.1\|WP_038696438.1\|1202192_1204580_+\|HAD-IC-family-P-type-ATPase	gnl\|CDD\|319851	cd07553, P-type_ATPase_HM, P-type heavy metal-transporting ATPase; uncharacterized subfamily. Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	7.42788e-152
NZ_CP009278.1\|WP_038696441.1\|1204605_1204782_+\|cbb3-type-cytochrome-oxidase-assembly-protein-CcoS	gnl\|CDD\|377073	pfam03597, FixS, Cytochrome oxidase maturation protein cbb3-type.	1.17661e-18

>NZ_CP009278.1|WP_038696449.1|1208470_1209979_-|ankyrin-repeat-domain-containing-protein
MKKIFLAALLFSALYGKAQNNNTLMNADFWKGAPTLAAVKTEISKGNSPSKPNAASFDPVTMAILNKAPNDVIQFLIEQEGNSVTKKTHHSRSYLHWAVSTGNIELVKYLIAHGSDVNYQDSHGYPIAAYAASTGNKNTAIYDLLFEAGVNPKQKYEDGATLLLLAVASDDDLKVTDYFISKGLSVTERDNFDRTAADYAAKLGNIGIIEKLIARGVKPTNEALFFATQGSKQITNGIETYKYLVETLHLDPKATNKDGATILQALVRRPNIEIINYFLDKNVDVNKADKEGNTVLMIASAGKDAKLVELLLSKTNNINAINDKGESALTRAITSGPSEIASLLLKNGADIKILNKDGNNLAYYWLNSYTETAPQGSRAAQGGNQQGNNFEEKLTLLKDNGLTVTDLQKNKSSLLHLAVAKENLNLIKRVASMGTDINAQDNDGMSPLHKAALIAKDDTILQELISIGAKKDLMTSFDETAYDLAKDNEFLTKNNVSIDFLK
>NZ_CP009278.1|WP_038696447.1|1207980_1208466_-|DUF2271-domain-containing-protein
MKISLKYILLISVITLFSANSFAQTSKFKCMIQMNSYEGEGAYVIISLINPKGAYEKTLSVLGPDKQWYNTLKEWHKFQTKSNGKLSAITGASVGGGDRAMRTIEIDDAKLNKGYKLRFESAVEEQKYHVTDVEIPLTVESLAERANGKGYIRFVKLSKVQ
>NZ_CP009278.1|WP_038696445.1|1205790_1207974_-|FAD-binding-oxidoreductase
MTLSIWRYAHLALAVVSSLFLLILSLTGIILAIDAVNEKTQAYQVENSSSINLAQSITGLRKVYPEIIEIAVDHNQFVSIDALDEEGNTIKAYINPITGAVLGEIKPKSQFIQWTTALHRSLFLHETGRIIVGIVSFLLLLISISGIALILKRQQGIKNFCAKINRDFFAQYFHVVSGRLFLIPVLIIALTGTYLFMARMDLMKRPNEEIKHKLIGGTENKKIEEFRIFQENTFADLEKIDFPFMDDDPEEYYTLKFKDRVVTVNQFNGDIISEVKYPYTAALEKLSLDIHTGRTNVIWAIILGLASLNIVFFIYSGFVITFKRTKTKVKNKYKADQAEIIILVGSENGSTLFYANQIHKQLLGDDKRSFLTSMNQYGKYPNAQHLIIFTSTYGIGTAPTNASNFEELVLKFPQNKHVHYSVVGFGSRVYPDYCAYAAQIDEILEKQNWTTRFLALHKINDKSIPEFTNWIHHWSEKSCIALATAPSLYQAKVDGIRKLKVIKKTGEDHATFTVLLKPQSKLKFESGDLLAIYPAHDNRERFYSIGQNNGMIQLEVKLHENGLGSNFLYQLAENDIIRARVMRNPDFHFPKVPAVIMIANGTGIAPFLGMIRNNKNTAIHLYAGFRYDNSLTQRYQDFAREQIANNHLNTFHFAYSREQKSQYVMDLIKQDVLLFLAHLESGGVIMICGSLRMQRDVEQVIEEITLLHKDRALSHYKESNQILTDCY
>NZ_CP009278.1|WP_144243398.1|1204801_1205677_-|FAD:protein-FMN-transferase
MGSVFEITVVDHDSTTAHHHIDLVIAEVSRIENLISEWRPESQISEVNRNAGIKPVRVDREVFNLTKRAIAYAQLSNGAFDISIIALDKIWQFDGSMTALPSEEVIRKSVEKVGYNHIILDSINSSIYLALPGMKIGFGSIGKGYAADMGRTLMQAKSVKAGIVNASGDIATWGLQPNNKPWLIGIKNPFKSYKTIKILKMKESAVATSGSYEKYAEIDNKRYAHIINPKTGIPATGLTSVTIYGPSAEFANALSTSIMVLGQKEGVKLVKRFPDYDYLFITDKGKVLKSN
>NZ_CP009278.1|WP_038696441.1|1204605_1204782_+|cbb3-type-cytochrome-oxidase-assembly-protein-CcoS
MSIIFMLIGCSVFLALIFLGAFFWANKTGQHDDTYTPSVRILFDDDLEEIEPKQVLKK
>NZ_CP009278.1|WP_038696438.1|1202192_1204580_+|HAD-IC-family-P-type-ATPase
MVEIKDIQVNQSCFHCGDALLSSDYRYDDHDFCCLGCQTVYQILHDNNLKSYYRYNQHPGKSNKGEIANLAYLDEPVIADKLIDFKGEQITIVTFYIPVIHCSSCIWLLENLYKINPNVLSSQVDFMKKQASITFKHQDLSLRNLVALLISIGYEPKVTLQDIVKEGKKANSNPLIAKIAVAGFCFGNSMMLSFPEYFGLASFEKSYSLFFGYANLLFAIPVLCYSASDYFKSAFLSIRQKRLNLDVPLALGIFILFVRTAYDVITQSGAGFADTLCSLVFFILIGKWIQEKTYHHISFERDYRSYFPVAVTTIVDGKEKAIQLADLQIGDRILVRNNEIIPADALLLNGEACIDFSFVTGESKPVAKTLGEVIYAGGRQTAKAIELEVVKSVSQSYLTRLWNNENYKHYDKPFQTFIGYISKYFTIVLLLIAVSATVFWMIDQDGNKAWGAFTAVLIIACPCALALSSPFTLAAALSVFDRNKFYAKNAATVEQMATVDTVVFDKTGTISSPMVNGIAFEGFLTAEEKRLVYSSCRNSSHPLSREIVKWMEDIEAVPVNSYQESVGEGSVTHIGRAIVKIGSARFVGASKTIGEESHVFVSINGEVKGCFSMEQSWRPGLSGVIHNLKKYDLHLISGDNDHKKDVLKDLFPPTAQLMFNQSPLNKLEIINLIQENGRHICMLGDGLNDAGALKAAALGIAVSDDINNFSPGCDAILDGASFEKLPQFFDFSKDVVRVIHLSFGISLFYNVIGLSFAVQGQMSPLFAAILMPISTVTIISFTSLLTHWYAKRRGL
>NZ_CP009278.1|WP_038696436.1|1200806_1202183_+|oxygen-independent-coproporphyrinogen-III-oxidase
MIDNTSESRLQALIEKYNVAAPRYTSYPTVPFWDNDHFSPDEWSTRVYHSYQKSKDAGISLYIHLPFCESLCTYCGCNTRITKNHRVEIPYITSLLKEWGMYTAILKDGAPLISEIHLGGGTPTFFAPEHLAKLINGIKAQAQIAKDASFSFEAHPGNTTYEHLAVLYQLGFRRLSLGIQDFDPLVQFTINRKQEVADVQRVMREARTLGYTSINFDLIYGLPKQNLATITDTLKASLKLNPDRISFYSYAHVPWIKPGQRHYTEEDLPRGEEKLALYTAGKKLIQEAGYEDVGMDHFARIGDELFLAFQQERLHRNFMGYADRYRPLLIGLGVSSISDSWDGFAQNAKSVEEYQKLLAQNEIPVVKGHLLDPEDLVIRRYILDLMCKGKTKFVSGFPFNEAILNRLEVMILEGLVTEEEDIITISPLGKSFLRNVCMQFDLKLQQSKGEKKLFSQAI
>NZ_CP009278.1|WP_038696434.1|1200388_1200802_+|lactate-dehydrogenase
MKVVVYSIQTHEKELLAVANGKMHDLTLIANGLNEETKVYASGKDVVVISGADILKSSMIQTLKSMGVARIMTRTLGTDHIDLVEAGNLDIQVANTPFEDQSPKGIAEQTIRNLNLWGAGKCVGTACCCLKDCPVKS
>NZ_CP009278.1|WP_038696432.1|1199130_1200192_+|response-regulator
MEKKTILIIEDNSDIREGATEILELTGQYHVIAAENGRSGVELATTHLPDLILCDIMMPELDGYGVLYILSKNEETAHIPFIFMTAKAERSDMRKAMELGADDYLTKPFDDVELLNAIDVRFKKRGQIGEAITIKNSLYLSSEEQDFLLKELVDKSRVKVFKKKQPIYEQGDSPVFVYFVISGTVRNFLCYEDGRELSTDMQLAGTYLGYEAMLLNEKYSDNVETVDKSEIALISKEDFFELMYRKPLIAGKFIKLLTGNIRGKEEQLLGFAYGTVRKRIANALISVVEKSMDLGNDDECVIQISREGIATIAGTANETVSRILSDFRDEDLIAKEKSAIRIISVKKLRNIKQ
>NZ_CP009278.1|WP_038696430.1|1197933_1199124_+|PAS-domain-S-box-protein
MDSAKLLEAIIDHAIDGIITIDNRGIIESINPAASSLFGYTGEEVIGNNVSMLMPEPYHSEHDSYISNYKSTGHKKIIGIGREVLGRKKDGTTFPFRLAVSEVWYKRRNIFTGFIHDLTREKLAENRLKRHAVELEQKVSERTKDLIMLVSELEKTKAEVSKSLEKEKELGQLKSRFVSMASHEFRTPLSSVQLSAALIDKYIEKPDFASVLKHTNKIKGSVQLLTSILNDFLSLEKLEAGVVTVDKKMINVVELAEEITEEMQLICKKNQHIIYQHTGAVGIFMLDANLLKNAVVNLISNAIKYSGEDTFIEFNTIVDADTCIIKVRDNGIGIPVEEQVNLFEPFFRAHNTGNIPGTGLGLNIVKRYVHLMEGTLEYKSAINEGAFFKMIFTQEK
>NZ_CP009278.1|WP_038696451.1|1217319_1219458_+|cytochrome-c-oxidase,-cbb3-type-subunit-I
MQLEQFNYDNKIVRNFGIATIIWGIVGMSIGLLIATQLVWPAMNFGIQFSTFGRIRPVHTNAIIFAFVGNAIFMGVYYSLQRVLRARMFSDLLGKIHFWGWQLVIVASAITLPLGLTTSHEYAEMEWPIDLGITLIWVVFGVNMFGTIIKRRERHMYVAVWFYIATFVTVAVLHIVNSIQLPVSGWKSYYVYSGVQDALVQWWYGHNAVAFFLTTPFLGMMYYFLPKMANRPVYSYKLSILHFWSLIFIYIWAGPHHLLYTALPGWVQSLGVAFSIMLIAPSWGGMINGLLTLRGAWDKVRTEPVLKFMVVALTCYGMATFEGPMLSLKQVNAIAHFTDWIVAHVHVGALGWNGFMTFAILYWLIPRIYRTELYSKKLASAHFWIGTLGILFYAIPMYWAAVVQGLMWKEFTPEGVLKYPNFLATTLEIIPMHMMRAFGGALYLGGAILMTYNLVKTMRQGKLLADEPAQAPALLPLTTNEKSTHRRLERKPVMFMVLALIAILIGGVVEMIPTFTISSNIPTIASVKPYTALEIQGRDLYIREGCVNCHTQSIRPFRSETARYGEYSKAGEYVYDHPFLWGSKRTGPDLHRIGGKYPNKWHFDHLLDPTITSPGSIMPVYPWLIDQELDNSLLTAKLKAMRTLGVPYSDQEIAHAQADLDKQAQAIVDDLKKNQVNVLANREIIAMIAYLQRLGTDIKAEPKQDEIVDEQN
>NZ_CP009278.1|WP_038696453.1|1219472_1219664_+|hypothetical-protein
MFKQITNLNGSELYLIASLWIFLVFFIIVGIMLFRMNKEHISYMKDIPFQEDDNNNSQSSDSL
>NZ_CP009278.1|WP_038696455.1|1219666_1220536_+|c-type-cytochrome
MGLFLNTTISNVETWTLGSGSVYQDILIIVFVVTMIVLLISALTVNKAMRSILRMTMPHILEEEKSVKIRRKESRKSFWNNLLGLRPISEEKDLMIDHEYDGITELDNPIPIWFNALFYSSMAFAVVYLLIYHVFSWGMNQDQEYVQEMGKAEIARQEYLAQAANLVDESNVIYDASQVAAGSAIFQANCVACHGGAGEGSIGPNLVDRYWLHGGEVKDIFKTVKYGIPDKGMVPWEQTLTPAQIAEVSSYIISIRDTKPANPKEPQGIEVTYVSADESPAGVDSTIVR
>NZ_CP009278.1|WP_038696457.1|1220547_1221930_+|cytochrome-c-oxidase-accessory-protein-CcoG
MKTGVANSPSNPAMSTKRKWVYAKKPAGDLYKLRQWVGYGLLLFLFTAPFIKIGGAPMLMFNIIERKFSIMGSIFYPQDLYIFVFGMLIVMVCVVLFTVVFGRIWCGWACPQTIFMELIFRKIEYWIEGDWQQQKKLNAGPDTHQKIFKKVLKHSLFLLISFFIANIFLSYIVGVDALYKIITDPIELHFGGLFAIFIFTLVFYGVFAHVREIVCTTICPYGRLQGVLLDDQSITVAYDHRRGEPRGKHKVALTQTKGDCIDCQLCVHVCPTGIDIRNGLQMECVSCTACIDACDAVMDKIGKPKKLIGFYAMGEIEGTIEKRNHTRAIAYSIVLIALISVFVLLISTRSDVGATLLRAKGSSYQLRDDGMISNLYAIELTNKSGDEMPFTLIPADKKLHIQVVNPMQSLAKDGHASLSFFLLINKDEVKKYKEDVKVEIYSGDRKVKTLNTTFIAPPGM
>NZ_CP009278.1|WP_038696459.1|1221961_1222384_+|hypothetical-protein
MNWGNKIFISLGVFMLGIILTGIYMVSRDSDSLEDMDYYEQGLNYNQIYDKKINAIDQHAKPSLKVDRDTLYIKFVKPENKGKLLFKRPSDRSKDLELPFETRANVYQLPLSSFKKGAWKLEIIWSNGGMEFLTDHQVHL
>NZ_CP009278.1|WP_038696461.1|1222385_1223084_+|sulfite-exporter-TauE/SafE-family-protein
MSYQYFAFFMGLFGSIHCAVMCGPLLLAIQGSQKISWHMAINKLLYQLGRLLTYGLYGIVLGAIGAIATIQGWQQGASILTGVLLFTIGAFQIFQIRYKLFIKLQGRLVQPIAKLMSCWLNRPGGSFVAGVLNGILPCGMLYMAAAAAMNTESSLSSFFFMIMFGLGTLPLLLVFSFFGNVVRTYFRVNFSRWLPFLYLLMGIWFLLRGANLDIPYLSPLLHVDGAMDCNFT
>NZ_CP009278.1|WP_038696463.1|1223076_1224531_-|efflux-transporter-outer-membrane-subunit
MKNINRHICLLAAILLLFSACKVGQRYQAPNYNLPDNYRLDSNGTDTLENLAYVNWREFFTDSSLVKLIDAGLSNNYDMRTAILNIQIANRQLNQAKAGYLPELDAKIAGVNQQWRSNNFYSSPSSKIYDGKEANNNLFRYQSQYMSELNLSWEIDIWGKISSQKEEALANYLGTAEAKNAIQTSLIANIATGYFNLLKLDAQIEVALRNVQLNDSTLRMIQLQFDAGEITSLAIQQTQSQRLLAASLVPQLEQEIQIQENALLELTGSMPDKIERGKSLKYLIDESKISLGSPLNLIRNRPDIREAEFDLIAANAQINIKQSLRYPSLTLGGTLGVNSMLPENWFNIPGSLLGSALGNLTMPIFKNKKLKTDYEVAKLESEKAEIALQKTVLRSVNEVSNSFTSLSKLKEQLVLAEARVDNSHLAVKNASLLFKSGYATYLEVITAQSNALTSELNLVSIKQSQLDSFVELYKSLGGGWSATK
>NZ_CP009278.1|WP_038696465.1|1224540_1227696_-|efflux-RND-transporter-permease-subunit
MLKTFVNKPVLATVVSMLLVVLGAVGLKMLPVSRFPEIAPPSVVVSLSYPGANAETVAKSVLLPIEEAINGVEDMTYIRSTASNSGSGSVQVFFKTGINPDIASVNVQTRISKAIGSIPSEVNEAGITVMPRQSGVIMTINLFSDTKESMFDETFLQAYSQINIIRPLLRVDGIAQVSRVGARDYSMRMWLNPEKLAVFNLIPDDVIAAIKDQNFEIAPGKFGETSDEVFETVIKHKGRFSQPEEFENIVVKTNKDGSILYLRDLARIEFGSSNLGSDNKVNGNPGLTLNITQTSGSNAHDIDIEVRKVLEELSKTFPEGIKYEVSYSVRDQIDSSISQVKHTLFEAFILVFIIVFIFLQDFRSTLIPAIAIPVSLIGTFFFLNLFGFSLNVLTMFALVLSIGIVVDDAIVVVEAIHLKMHETGMKAREATLSTMSEISGAILSITLVMAAVFIPVGFMEGPAGIFYRQFAYTLATAILISAVTALTLSPALCALILKAPEHGEESTQPEKNKFTAYKKRFFTAFNTSFDSLTSRYILGVKYLIRNKKIAITGLVVISGLGFALLLLAPKSFIPTEDDSFVTYSLAMQPGASLARTTEVLRRADNILQKRNPDISGMTTISGYNALDGSTSPAYAVGYINLKSYDKREKIKNIEHFMDTIRQDLSVINEATFNVFPRPTVQGFGDFAGIQLVLEDKLGGEILDFSTIADNFINEINQLPEVKSAYTSFKANFPQYEVDIDAVKAKSLGVDIKSLMSTIRAYYGRVQAGDFSRFGRQYRVYIQADYDYRTDPESFKSIFVRNKNNEMVPISTLLTLKKVVGPETITRYNLYNAITINANPNEGYSTGDAMNAIEKLAIEKLPGNYDYEWTGMSLEEAESGSQTVLIFIMSIVFVYFLLSAQYESYILPWAVLLSIPVGLVGVYATILMVGLENNIYVQVGVIMLIGLLAKNAILIIEFAVQERNKGLSIYDSAIAGAKLRLRPILMTSFAFVAGLIPLMWSSGPSAQGNHSISFGAAGGMLFGVILGIFIIPVLYVIFKTLDERLKNKFKTN
>NZ_CP009278.1|WP_038696467.1|1227730_1228891_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MNKISLFTLALCSSGILFFSCNSGKTKELDKKNNAIALPIYSIDTSSANTIKDYIGTIEGKVNVEIRPQVEGVLEEIYVDEGDFVEAGQKLFKINASAYDEIFNNMVATENVAKAKLQNARLEIERLRPLVENEVISEVRLKSAQSEFDVAKASLQQASAAVRSADINKQFTTIKAPVSGYIGRIPKRVGNLATKNDAQSLTVLSDVQEVYVYFSMSESDFLYFTKKQAKQDLQDSIHTPSGKIRKLAFPEVSLVLADGEAYSQKGKVDAVNGQVNRTTGAISLRATFPNMQNILRTGSTGTLKFVETQKGVIQIPQVSTSELQDKTFVYVVDKNNTVHRRAIKIEGKSNSNYIISEGLAVGERILLSGFDKISEGATIIPIDKTQ
>NZ_CP009278.1|WP_038702164.1|1229148_1230624_+|cardiolipin-synthase
MSQIDIDWNQLWQWLLNWYWLPLFILYFGVISTILIENRNPTKTISWVMVIVFLPFIGLILYYLFGQKFRKVRRLQHINREQHPKLMAAWEESLIRMDEQLETIYKRIGTLSRVFDYLKNQKLAFFSLNNRVELFINGEEKFPVLLRRLREAKHSIHMEYYIFELDNIGTQVLDILEEKAKSGVQVRLILDSFGSPDVIKHLSKHPPSYQFVAFLPVNFTSLANGNYRNHRKIVVIDCQYGFVGGINISDRYINHPHQRDYWRDTSMSVEGIAVNNLQIQFWNSWNQTEAEPFLLSEEYLNFNIEHMPEKAAVSFSSSDPGSLGPFNMEAIILAINEAKESIQLCTPYFIPSEQLSTALEIAVSSGVKVALMLPEKSDSYIVQHASFSFLKPLLQRGVQVYLYNKGFIHAKTICIDGQLAFVGTVNLDMRSFYINYEIASVVSDESYCKRLEHQFEIDKETSDLITLYTWAHRKKWKRGIDSLCRLLAPLL

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Crispr_ID: NZ_CP009278_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009278_2

2282632-2282760

Orphan

Consensus_repeat	Method
TCTTTTCAAAAACCCCTAGCTCCGAAGAGCTAGAGGAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009278_2

>merge|NZ_CP009278|2|2282632-2282760|CRISPRCasFinder
TCTTTTCAAAAACCCCTAGCTCCGAAGAGCTAGAGGAGTCAGCCAATCATCTCAATCGCATATAACCAATCTATTATAATCCATATCTTATCTTTTCAAAAACCCCTAGCTCCGAAGAGCTAGTGGAGT

>NZ_CP009278|2|2|2282632-2282760|CRISPRCasFinder
TCTTTTCAAAAACCCCTAGCTCCGAAGAGCTAGAGGAGT	CAGCCAATCATCTCAATCGCATATAACCAATCTATTATAATCCATATCTTA
TCTTTTCAAAAACCCCTAGCTCCGAAGAGCTAGTGGAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009278.1\|WP_038697890.1\|2276071_2279416_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_CP009278.1\|WP_038697879.1\|2265725_2268863_+\|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl\|CDD\|223683
NZ_CP009278.1\|WP_038697909.1\|2288041_2288488_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038697911.1\|2288913_2289240_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038697888.1\|2275275_2275974_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038697894.1\|2280810_2282064_+\|redoxin-family-protein	unknown	unknown	gnl\|CDD\|239264
NZ_CP009278.1\|WP_038697886.1\|2273667_2274288_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_158500280.1\|2282867_2283755_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NZ_CP009278.1\|WP_038697884.1\|2272865_2273126_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP009278.1\|WP_038697906.1\|2286721_2287393_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038697913.1\|2289779_2290733_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NZ_CP009278.1\|WP_038697902.1\|2284821_2285823_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_144243296.1\|2283966_2284356_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038697881.1\|2268925_2272750_-\|ATP-binding-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038697914.1\|2290732_2291302_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_144243297.1\|2287748_2288030_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038697892.1\|2279426_2280785_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|185760
NZ_CP009278.1\|WP_051959847.1\|2273375_2273633_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP009278.1\|WP_038697896.1\|2282142_2282370_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038697904.1\|2285921_2286293_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133390

Protein	Function_ID	Function_description	E-value
NZ_CP009278.1\|WP_038697890.1\|2276071_2279416_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	1.57746e-129
NZ_CP009278.1\|WP_038697879.1\|2265725_2268863_+\|type-I-restriction-endonuclease-subunit-R	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	8.5131e-124
NZ_CP009278.1\|WP_038697913.1\|2289779_2290733_-\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	2.35778e-17
NZ_CP009278.1\|WP_038697894.1\|2280810_2282064_+\|redoxin-family-protein	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	2.31778e-13
NZ_CP009278.1\|WP_158500280.1\|2282867_2283755_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.11653e-17
NZ_CP009278.1\|WP_038697884.1\|2272865_2273126_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.32284e-09
NZ_CP009278.1\|WP_038697892.1\|2279426_2280785_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	6.90046e-30
NZ_CP009278.1\|WP_051959847.1\|2273375_2273633_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	7.07213e-09
NZ_CP009278.1\|WP_038697904.1\|2285921_2286293_+\|hypothetical-protein	gnl\|CDD\|133390	cd04762, HTH_MerR-trunc, Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins. Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.	0.00479606

>NZ_CP009278.1|WP_038697896.1|2282142_2282370_-|hypothetical-protein
MALFALTGLNPSNPAHYTYITGTPPVCANPTQQMCTLQADNDGSGLPIITPALKDEMINSLQNQVNGPNVSLKSR
>NZ_CP009278.1|WP_038697894.1|2280810_2282064_+|redoxin-family-protein
MKYLKLIALQICLLMLCSTSHAQTDQKVDLSKALKIGDTFILPTTVKLTRGLNNTIDWKKLNDKVVILDFFDTSCGTCIQTMPKLQKLQDKLKDKLQIISVGWQDKATLEKLFENNEFLKENKVNLPVIYSDVYLKERFPHQGVPHVVFLYKGIVQAITSSKLITEDYILELYDKGTIDLPLKDDFGKGNLMASSKNGLQIKGMVTLSGYQNGVPFESFKRQKDSINDLQKTSFYNVSIYSAVLSTWAKIQKADFIPRPERLLLKVKEPNRYRDTANIGDVWYAQHAISYERLDAIQRTDSAQAKVVLQDLHSFLGIRTYKMMKSIQCLILKPCPIIPYTGKAPLNGLTFEGSSVLAVMTDMGRQFPPVLDLVKSKVVIKLGDYNNLEELNEQLATYGIVAEIGMGEQEVLVIEEME
>NZ_CP009278.1|WP_038697892.1|2279426_2280785_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKTNNLTVGIWTMLLFCGCSNFLEEKPDIKMVIPKTLNDAELLLNNYSAMNTGYPLFGEWGADEYYLTDENFDGALNFEQQNTYSWLDEPNNDIMQWQRPYKVVYNANQVLEIIDNLGTIGSDKKSKNLSGIAHFYRAFAFQQMLEVFAPAYQAGTAMTDLGIPLRLDPGIDEPSTRASVQQSFDQVIKDYKTAVWQLPLQEAIKGRPFRASAYAGLARTYLYMGNYQQAYLYADSSLHIHANLMDFNTLNASADLPIDRFNVEVLFAAITGTSGPMSLNNGLVDSTLYRSYADNDLRKTLFFRKNLFPQNTYGFKGNYDKALATIFVGLTSSEMYLVKAEAAARIGKVTEALSTLNTLLKKRQDENQFIPVTEMSPNLLLPLILKERQKELVFRGRRWSDLKRLNLDPRFQKTLKKVVKGKEYTLSPNSIKYAFRLPEPVVIIGKIPQNLR
>NZ_CP009278.1|WP_038697890.1|2276071_2279416_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKSKIEYINKLWKYLQTLLKPGGENLLVISKMLMLILILPFPMVGIVHDVHAANKADVQVDYVLKGTVISAVDGKPLEGVSIKVEAEKGRSSTKKDGTYSLNVEHRKGLVKFSYVGYKSQELNYTVGVSLSVKLIPEENKLEEVEVVSTGFQKIPKERATGSFEFVDNKLFNRKVSTDFVSRLEDVVPGITASKVYNNRGGYLNINVRGMSTMRSERWPLVVVDGVPYETYYQVAGMGAFNNLNPNDIESVTVLKDAAASSIWGAQSGNGVIVVTTKKGKFTQAMQISFNANVSIKAKPDLYYYPQIKTSDYIDMQQFLFDKGKFNGQFNTWYYNPEPAVRLMEDRRTGAISEAEFNEKIVKLKAMDARDDFLKYIYRNAVKQQYNFQLQTGSEKANTLFSVGYDKNLNDVVTSSYQRLNLKSNSQFKPIKNMLVDIGLLYTESKNISSSVPVGYNLLGKGLQNYPYMKLADENGEPAVVEANSISNIYRDTVAGGRLLDWTYRPLKELYDSRETQKVRELFTNFNMNYTFDFGLSLNMQYAYQRSMNPSEVWRGVGSFYQRDAINAVASYNADAVTWNLPIGDNLNIFNWDSYTHQSRATAEYNKKWKDRHEISVFAGMEVRKTHKTLTTSQYQGFDPETGAFKPAPYGVAVPYFNGAFGTFYMRDYNQYQLFRNNFVSYFANASYTYVNKYILSGSFRKDASNLFGVKSNDRGQPFWSVGCAWVFSREPFLENGPFSLLKLRSTYGYNGNVNNSVSANPIMSIENEVNYINSQKYGMIMTPPNPRLRWERVAITNLGLDFAMKGNWLSGSMEYYEKNAKDLIAPDRIDPSTGFTSMMVNSANIKTKGWDISINTIPVVSKNWTWNSNLVFSYARTKVLKAYVQNEIGQDYISTGLANVMTPIEGRDLFSLLTYKWAGLDPETGAPRASLNGEISKDYSAITNTNVKDLEYQGSTIPLYTGSFRNSIRYKTIELSWNISYQLGHMFLRDSYNNHLLVNSSVGHKDYALRWKKSGDELITDVPAVTYPANSIASNVFIGSSALLESGSQIKLRDIQLTVDLPFASNFKLKNCKVYGYVQNVGTIWRANKWGIDSEYGFNIPDPMMTALGFSFTL
>NZ_CP009278.1|WP_038697888.1|2275275_2275974_+|hypothetical-protein
MQKSCTGESYALSQEKEMFSYLSKKKVPVIKKPIMITLLPERSFKKRMPYEGRHADALKSLAKGRPKERYYSFLNPSKELKSSYSAVVRDDRSDVLRITLAHMAIYECYLFAFGLPANFPTEQIIVYGYERAKYIPCKICPDSEKHLYNYELTVPANTEREEYRQRMLNDLNEHFQLDVRVEKLSIVKDSRQIMTKRGESVELIWQEQPTMIMKTKQVRVAASAENRLAANI
>NZ_CP009278.1|WP_038697886.1|2273667_2274288_-|hypothetical-protein
MNIPNSFIKNVSIARKHINLSEEDLDNLLREVGLIYSGIETMAKKSVSIELAYHLSKIFNKNIEYFICDNFTPLDLEYVNTKTQNYIKQNKKTNKDPKLITKFINAYVIIYIRDFAKGTKFTNTDIIPNLPPILNLETSIDWSSGLLKGLVKNTKTYRKSPDDIDPKNRGEVIYVLEDQVPDSIIEKAIKKVDAEWLIQQYEKSDK
>NZ_CP009278.1|WP_051959847.1|2273375_2273633_-|helix-turn-helix-transcriptional-regulator
MIEDIHSDLFKTIGSNLKNKRIELKLSQQVLADKIPKMDRAKISDMENGKEDFVFSKLLKLCDALELTLTEVTKKGSDKISSEQN
>NZ_CP009278.1|WP_038697884.1|2272865_2273126_-|GNAT-family-N-acetyltransferase
MKINHFFAIITIDTNEFAGAIALWLIDLENEYAKLGYEMLPEFQGKALMDSALKLILNHSTTLNINHIEAKMHRVNLKLRKLAERN
>NZ_CP009278.1|WP_038697881.1|2268925_2272750_-|ATP-binding-protein
MASNQGTVTTTEPEFSESNSNKQKNIRPSNVIKKLKYLKSWLNREWRAFYHFFTQIPLKIKIGISKTLIRIGERLSKSTRLLDAYLTQHSFNPNFENYEDLAPIDYADDERKYTNMLLWSLKNPKVTNVAITGPYGSGKSSVIRTFQKRHPEFRSVNVSLASFDENKDDDGEWRNKVELSVLQQLIYHEKSNSLPDSRFAKIRTISWYNRLAGTIFLGTLILSYLYITKTDYFNKLKFIDVKTKSILDVVFPTLLIFGSMYLLYKLYRTIRNLRFTKLSVVSADAEISDGEIRSVFNKHLDEIIYFFESTRIKLVVIEDLDRFNDTEIFTKLREINILINNSKQVKHRVTFIYAVRDNIFENNDRTKFFEVIIPVIPIISVSNAGDALSSKLSSIIPDKPISQELSKAVSLYIQDMRMLLNITNEFNLYSKQLSNDLNHEKLLSLIIFKNLHPEDFSDLHRGKGMIIKVIDKKRKYITEQKEKNNKDIAALQNDIKVIQSIKIKDISELRSLYLYKAISKLPHNGFLDFDGKKNPSNFIEDETFIWWHDGGKPLAYLISGYNTTAQHRLDFSFNQIEDEVDPHNNYSEREKQINLFHDEGINKIRANIEILKKETAVTTGKSLKEIMDSGGKFEFPEDSHISPILIYLMSNGYIDEYYHPYISHFIEGSLSEKDMSFVMSVLNRQPLPHDHELTNIGLIHKEWISIGQYSNTAILNFDLLNWLLQQESCEEEISLFIGLLRKNENILFIDDYRKLNKNQSELIRTLGNYWPEVWDYLYDESLYGDEILAQYASLIIQYLPLEKISMDINKNKKFSKFMSIIPNLYEREYMENTQDTLVQVIDELNVKFDDLRLLDKLPTALKATYQSNSYTINSQNLKYVIQNFGEYETFPKEAWESAQLTTILSSAATNLKNYIDDNLETYLNILNKNDLNIKESEDTIIMVLKNKDADIEMVKNFIRKQESLLSSIEDVPEIYWDFLLEEQRIVPTWLNVQKYLFYHGELEDTLTTYLNEPSVYATLKKIPFDLTAHSDSDDEINISHEILYRNELTIESYSSLLEPLPLNPDQIEIDKLSEEKINYLIDKSLINFASNTFSEIQSKYPKLISLYVEKHLDLFFESLSDLSIEDEAFVRMIQSPNISQENKANLIQHILTNYSMENHELGQIIVAFLSEYQSWPMQIDYAETTGLLKGAFSTSVRIRALTPVVTKLSREVYKEIESTFSEPYNQISQNDTRQRSFRNFTGLKPFVHNVQKLFSDHLGTIKDGKEKVTIYYKK
>NZ_CP009278.1|WP_038697879.1|2265725_2268863_+|type-I-restriction-endonuclease-subunit-R
MKYTESQLEQAFISLLETEGYQYINGKKLVRTSNQDVLMKDDLRAFFLARYPDLEEIELESLINELAFQSASNLYESNKYICKLLADGLIFKRNNPAKKDLHIRYIDIDTVSNNTFKIVNQLEILGSELRIPDLILYINGIPVVVFEFKTAIEEEITIHDAFKQLTIRYRRDIPELMKYNVFCVISDGINNKSGTIFSPYEFYYGWNKITGDEKKALTGIETTTSIVHGMLNQNRLVDIIHHFVLFPDTSKNELKILTRYPQYYASNKLYQNILKHRKPEGDGKGGTYFGATGCGKSYTMLYLSRLLMRSTDFASPTIIIISDRTDLDDQLSKDFTNAKKFIGDENIINIESRADLRDRLRGIESGGVYLTTVQKFAEDADILSDRTNIICISDEAHRSQVNLDLKVKIDEEKGVTKSYGFAKYLHDSLPNATYVGFTGTPIDKTLEVFGDVIDQYTMFESVNDEITVRLVYEGRAAKVNLDYNKVQEIEQYYENAVAEGASEYHVEASQKAIAKMEVVLGDKDRIKAIAKDFINHYENRIEEKATVAGKAMFVCASRGIAYKLYQEILALRPEWGEETLTEGLTDREQKEIKPIERVKMIMTRNKDDEKDLWDLLGSKEDRKELDRQFKQVKSNFKIAIVVDMWLTGFDVPFLDTIYIDKPLQTHNLIQTISRVNRKYQGKDRGLVVDYIGIKKNLNHALGLFNNQTTDDDFEDLSQAEIIVRDQVDLLRQFFHQFDTTNYFEGLPVARLQCLNKASELVLQTEESEKFFVNVTKKLKSAYNLVSGSELFTYNEVDEIHFYFAVKSIVVKLTKGEAPDTAQMNAKVARLVEEAIISEGVEEIFKLDDNKANAIDLFNDKFIEKISNLELPNTKIKILERLLKETINDFKKINKVKGQDFSERLQSIINRYNERSERDILDYDGIQADTAEQMLDLIIKLRSEMDSFQDLGIDYEEKAFYDILDLICKQYGFEFDNEKMLELAREIKKIVDNAAKYPDWADRDDIKAQLKMDIIVKLHQFGYPPITQDDVYKNVLEQAENFKKNR
>NZ_CP009278.1|WP_158500280.1|2282867_2283755_-|helix-turn-helix-domain-containing-protein
MGNTTLQEDILPTIGGTVYCYDFQVEHRIQVHIKVNESFIQLYHMMEITGQAKLTQHGSAIDFALLNRRGVYLYTPADHYTVQLDKGRYLVYGFCFDPEVQIGKNSQLKTILKPLLDAYYHHGQHLVASIPFRAEENTRAKHLDIFEMLQEGKSSQAICFSKTLDDVFEISIKKLIPTFEMHHPSRIFIDSARDMIVQHFATKDEDIAIKQIAINLQCSSDYLHNLHTRHYGISLISYKQGIRLKKAKRLLEQNEKVAYVAICCGFKDQTSFCRFFKRETKRTPIAYQRDYTTKI
>NZ_CP009278.1|WP_144243296.1|2283966_2284356_-|hypothetical-protein
MKQNLDNAGVAALQDHVLALLASDLLLETNLLRTDLQLYVDSRFDLSSSQQQQLQTMSPSFSTSLGQAIANSWEQGVRVDFYKEEKDEDKVPDPKEMTVFGLDPTVANDSQSAQTYAHPLMIRIRYNYK
>NZ_CP009278.1|WP_038697902.1|2284821_2285823_+|hypothetical-protein
MNFNNQTAIRQKQILYFTILFVFPIFFNLMGYDFKWNEIKILSAPFLLLSMAMLFIMLVAVVWISYVRHYFGDSLKEHGNFEKQWRIRVAYYSAALLPFLVFFTVLLLIWIWRYDRFWDIWKMYAIWRYPQLIVVLGIFSYVLIKNSTWALAILKGPSTVDRAVAEDKQAHAEEKVLPQVSLQLNELYDHILNVLGATIGPIYRDMIYVRFFDIVGILTRKSGYQLILSDGSMIDCPNILKKIIDLHLGHWMVKISDNYTINMLLVDWPDYSKGLQLIMKEPTLDGLREKLSEAEIEKMFKIGTGIRTREIKNFLEKKEQLTLQGWDTWVPLR
>NZ_CP009278.1|WP_038697904.1|2285921_2286293_+|hypothetical-protein
MKTIMTVPPELVWNRTLVSHTSGTCTSVNFVLAALKGDSTLLMDEKLDHIVRLLEGEKDELLGWMSSKDCCDYVAISDRTLYRKIKEGWINVAYLENKLRYFRKQDVLNLYIRYHQKTPKYMP
>NZ_CP009278.1|WP_038697906.1|2286721_2287393_+|hypothetical-protein
MVEYFKKNKMGTIRNGANGRFLGKAGSVIGSSWKGIDYIKGLSKKRTKPSTEEQRIQQARFYAISKFLMPIAPILRLGFGQVNADRMTPTNAALQLNIAQAVIGTYPSFELDYSKILISSGSFIGGGATAASVNSGVLTVDWDFALSTLYNSKADDQVIILLYQPTVDEFMTAPTPPLRAEGTVDITIPDHLLGDKGHVWVFFANRKGTKVSRSSYLGELDLV
>NZ_CP009278.1|WP_144243297.1|2287748_2288030_+|hypothetical-protein
MRKVIREGAAVMLSWEKGHNPDLGASWDDVLIFCAYDIAGASAAINEEGVIRQDGRLTMELPSGLHGRPVHLFLVVHDRDGVVYSSSVYLGLF
>NZ_CP009278.1|WP_038697909.1|2288041_2288488_+|hypothetical-protein
MLLKIMRVEQGNNSTLSEIYLNNQFICYGLEDIPREKKIPGSTCIPIGTYRLGFNRDGGMNGNYYDRFPKLHRGMIEIQGVPNFSHVYIHIGNTHRQTAGCLLVGTRYVFEHGDYRIEQSVTAYKRLYALLTELMVVREVFVQVMVTE
>NZ_CP009278.1|WP_038697911.1|2288913_2289240_+|hypothetical-protein
MKKILIKINRVLQVVLMAPIKLPAKALNILKYIALGLGVVETVLEDKDEKESGAPPDEAGQLRAKEDGLPVSDMEDVSSSNVFSNEIDNVIDLNKEFTTGKEAIDETE
>NZ_CP009278.1|WP_038697913.1|2289779_2290733_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MPTNYLHHHKDFKSLILIVSEQKGIDPILIEKDYWIMHCLFALKQAGYVFELKGGTSLSKAFKIIDRFSEDIDIHIHPPVDLEINENPKNYKPSNSKKRLNFYNNLAKDIKIDGIIDIIRDTSFDDLQYYRSGGIRLIYSSLFKAAPGIKEGVLLEVGFDNINPNKPIDITSWVYDTAKKTQVKFIDNNAVAIPCYDMRYTFVEKLQTIATKFRVMQQTNTMQVNFMRQYYDVYKLLQQTEIQNFIGSNEYYTHKERRFPAIDFAIPMNENQAFLIHDKQIEEQLDKLYINSNALYYNGQPDFKIMVEYIKSYLDLL
>NZ_CP009278.1|WP_038697914.1|2290732_2291302_-|hypothetical-protein
MYKLDDLRKKLRKGKVYRREDLAHWSKSVDRHLVELLEEGKLKKLAQGLYYVPNQSAFGSTPPDEDEVIKKYLKGDDYLLTSPNYYNTLGLGTTQLYNRKRVYNHKKHEDVQLGNKIYEFRRKSKFPKKLSQEYLVVDLLNNLKNMAEDQGMILHNLKNNIANWDKLDLKKQVQRYGSINTRKIFEQIM

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Crispr_ID: NZ_CP009278_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009278_3

4967235-4967305

Orphan

Consensus_repeat	Method
ACGATCAGTCTAACTTACTCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009278_3

>merge|NZ_CP009278|3|4967235-4967305|CRISPRCasFinder
ACGATCAGTCTAACTTACTCACCAAATAACCTGACGAGTAACACAGTGACGATTAGTCTAACTTACTCACC

>NZ_CP009278|3|3|4967235-4967305|CRISPRCasFinder
ACGATCAGTCTAACTTACTCACC	AAATAACCTGACGAGTAACACAGTG
ACGATTAGTCTAACTTACTCACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009278.1\|WP_038701469.1\|4958559_4962300_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_CP009278.1\|WP_038701465.1\|4953546_4954272_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_051960168.1\|4958191_4958440_+\|DUF4974-domain-containing-protein	unknown	unknown	gnl\|CDD\|379829
NZ_CP009278.1\|WP_081918452.1\|4973106_4973280_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|379098
NZ_CP009278.1\|WP_144243376.1\|4955757_4956012_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038701479.1\|4971822_4972137_+\|transposase	unknown	unknown	gnl\|CDD\|225511
NZ_CP009278.1\|WP_144243378.1\|4972121_4972646_+\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP009278.1\|WP_038701475.1\|4968120_4968651_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_158500330.1\|4974034_4974244_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275209
NZ_CP009278.1\|WP_038701473.1\|4967617_4968007_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038701471.1\|4962311_4963772_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|185760
NZ_CP009278.1\|WP_081918454.1\|4974632_4975049_-\|Fur-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223806
NZ_CP009278.1\|WP_051960165.1\|4956482_4957115_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|274376
NZ_CP009278.1\|WP_051960167.1\|4957237_4958134_+\|FecR-domain-containing-protein	unknown	unknown	gnl\|CDD\|377406
NZ_CP009278.1\|WP_051960173.1\|4965818_4966976_+\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
NZ_CP009278.1\|WP_081918451.1\|4963762_4965808_+\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|366374
NZ_CP009278.1\|WP_051960181.1\|4975460_4976705_+\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|223597
NZ_CP009278.1\|WP_051960177.1\|4972672_4973044_+\|transposase	unknown	unknown	unknown
NZ_CP009278.1\|WP_038703156.1\|4954268_4955288_+\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl\|CDD\|378065
NZ_CP009278.1\|WP_158500329.1\|4969977_4970388_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP009278.1\|WP_038701469.1\|4958559_4962300_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	1.16422e-131
NZ_CP009278.1\|WP_051960168.1\|4958191_4958440_+\|DUF4974-domain-containing-protein	gnl\|CDD\|379829	pfam16344, DUF4974, Domain of unknown function (DUF4974). This family consists of uncharacterized proteins around 340 residues in length and is mainly found in various Bacteroides and Parabacterodies species. The function of this protein is unknown.	1.14318e-15
NZ_CP009278.1\|WP_081918452.1\|4973106_4973280_+\|IS3-family-transposase	gnl\|CDD\|379098	pfam13276, HTH_21, HTH-like domain. This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.	1.00458e-05
NZ_CP009278.1\|WP_038701479.1\|4971822_4972137_+\|transposase	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.84158e-09
NZ_CP009278.1\|WP_144243378.1\|4972121_4972646_+\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.6714e-32
NZ_CP009278.1\|WP_158500330.1\|4974034_4974244_+\|hypothetical-protein	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	4.95595e-10
NZ_CP009278.1\|WP_038701471.1\|4962311_4963772_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	8.59356e-23
NZ_CP009278.1\|WP_051960165.1\|4956482_4957115_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	2.73585e-39
NZ_CP009278.1\|WP_051960167.1\|4957237_4958134_+\|FecR-domain-containing-protein	gnl\|CDD\|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	8.4876e-21
NZ_CP009278.1\|WP_051960173.1\|4965818_4966976_+\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	8.16645e-33
NZ_CP009278.1\|WP_081918451.1\|4963762_4965808_+\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|366374	pfam00930, DPPIV_N, Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.	4.99835e-72
NZ_CP009278.1\|WP_051960181.1\|4975460_4976705_+\|GTP-binding-protein	gnl\|CDD\|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	2.73083e-114
NZ_CP009278.1\|WP_038703156.1\|4954268_4955288_+\|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl\|CDD\|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	1.57882e-27
NZ_CP009278.1\|WP_081918454.1\|4974632_4975049_-\|Fur-family-transcriptional-regulator	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	6.76202e-14

>NZ_CP009278.1|WP_051960173.1|4965818_4966976_+|TlpA-family-protein-disulfide-reductase
MKFLSSILLLVFSITIAYGQDSAVIKGHISRLNDHNISIQYKEDGKRKKIVVPCTAGEFEVTLSVAHALEVNIYPEKYFDNAVQIKGSKSYLIAPPLLLFVAPGDVITVEGDAMQLWTATTTGGQFSKQLAQFNKSFVPLTTAIFNLSSKQQNWKNQDLQDSIKKVREEIRGLASDKKRIVMDYITAYPDNLFSLNLFTQRMGGLSTDKVNDIYNQFPVDLQQSFYGTAVKDFMTKNENAALGKEMIPFSGKSLTGEAIHSSDFRGKYLLLDFWGSWCQPCRKSHPHLLALYNKYKSQGFEIVGIAQERGSDPISSWKKAIKEDDINWIHLLNNQQKEKQDLVSEYHVSAFPTKILIDPTGKIIWKGIGNAGNELDSKLAELFGE
>NZ_CP009278.1|WP_081918451.1|4963762_4965808_+|prolyl-oligopeptidase-family-serine-peptidase
MAIKHIRSRFGLCLCLVLFGMFAKGQIRLDTTVVKALPHILGWKDNEHYIQSKYIGKQQHLTVIASKTGKVTAEDSTTNSNTRSTAEPEPLKIKGAILPLLSPDKKWIAYLKNNNLYARNVETDQEIQFTNDGTSTWMNGYASWVYYEEILKRDSHYRSFWWSPDSRYIAFYRFDDSKVPTMLLHNPIGQHGRTEITHYPKAGDPNPTVTLGIASLEEQCVRWSDLESAKDHYLGTPFWRPDSKGLLVQWMPRRQNQLRLLDVNPTTGDYTSIYQEQQETWVDWIKKIYWTNEGFFLIRDFSGWEQIYQYAHDGRLKNIVTSGKNWDTQILRIDSGEKVIYFTSSAENAIRTYLYKVRWDSREQKRLTFGDYTHNKILLSPKGDKFITQYSNASTPTRIGLVDSRSGKVIDIADSKAAQFDTTRIRKKEILWLRTEEGMMLPASVSWPKQMVKGRKYPVTIRIYGGPKYSTVTDSWSTPMINSNDDQAIRVVFEHRGSGHNGKSGLNYLYGNLGKWEIQDYISWVKKLKENPFVDPDRIFINGGSYGGYLTALALTLGAEHFNYGIADYPVTDWKLYDSHYTERYMGLPKDNPDGYRYGSVMTHVDRYQSYGPAMLLIEHGVMDDNVHIQQSYQLVDLLQRKNKKFELMIYPTERHGWKGPKIPFTGSVKEAFQQKYIFNK
>NZ_CP009278.1|WP_038701471.1|4962311_4963772_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKLKNSIYSCIVVVLLTSCNKWLDLQPTGKILLDSAEEYGMLFDNITTYDIADIAYISDENWLNAQNVSSVWGAPNLATANFLFLTEYDRSLNASGNSGTNGTSMYQTLYQRITKIANTIIYEKDNMSGTTAEKASVIAESKMLRAFAYFILINTYAKPYDKATAATDGGVALKLDPLIETQPSLAKSTVAEVYQQIETDINDAIPELNINAKTPYRFNKAAAYALKAKVHLFKKEYDACIAAALQSYKLNHQTYDLVNLIDASNNKPSTPIYATGEENLFFATTGTSYTYIGEEMIYLYRNGLLANGQSNAVKDVRLDLYKQPASTIKDYKHMRAWEPNAKEFSVNNVGLTTTEVMLMLAECYARKGEYERTKQYLKPYLQSRYKNYDHNSFTLPSSEENVVNFVLAERRKELVRGINRFLDLRRLNTEVAYQKTVSRRFPADPVATPNVPQQDFVLPVKSPLYILPFPSKVLENDPRLTSNSWQ
>NZ_CP009278.1|WP_038701469.1|4958559_4962300_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKLKDISVVGWKLAPPIGGALPKTKLAMKLTAVFLLSGTLLVHANAFSQKVSLHQKNSSLKTVFDALKKQTKYQFFYEPEVLNKAIPISLHIKDSEFKEVLDECFRGQPMSYSIIGNTVVVKLKPKAEQRNAIIQEMVVSGRTVNTKGEPLSGITILEKGTRNATASDDNGHFTLKKVKVDATLLFSSVGMLSKEVGVNNNQNMGTITLEPKVILGEEIIIEVNTGYQTLSRERSTGAYDIIDKSKIEKRIFTNVTEILEGQAAGVSAYKGAPVVRGISTFSSNIGNDPLLVIDGLPTERNLDDINVTDIETITVLKDAAASSIYGVRAANGVVVITTKGGNLTDQNKTAVQFTSDWRRIENPSLADYHYASTKGIIDYQLATYKRNADKANQSELDYLTNNLKGIGQAGSTSNSINYYSPLQMTRLQYLNAEISKKDYDNALSEWAKNDYRQEYMDLAWQTPFRQSYNLSINSSGKSQSTFASLNYIKDGQQNRFEKNQYIKGYIKSTQVLNEWFSFDIGSDIQYNGRQNISSVYGNLNLLEPYTAILDENGDKIYRDYVDIIGMQGGLHVNPKILSAINGQPQFESYRFNILDELKDNQTNQNNYTIRSFARLNFNLGKGFRFSTSGEYEFGKANMEEFRSRDSYFYRFLRNKFATKDPANSIIPIGGRMQMEETSRNSWVWRNQLDYNRSFGNDHQVTATGGLELREININIPTNALYYGYDPIALTYTQLNNYDIYHVGYRNSYIYNNATGLPDAVLDGNNIKIADSDMYPSLSAVKNRYVGLYAVSGYTYKGKYSATGSVRVDQTNLFGTDPKYRYRSLWSAGLKWNIAKEGFMHALNWVDILDFRASYGLTGNVDQTTTPFLVASLSNQSSYTAQSIPYASISSAPNPMLRWEKTTSYNVGFDYSLLKGKLSGKLDLYYKNSEDLLGSKEVHFTSGYTTQRVNSGAMRNTGFEITVGSPWFKNKEWVVSSTLLFAYNKNKITKTYYNPTQASHLAISGYLVNGMPYDALYAYRYGGITSGGTEYQNGVPIIERADGTTMHHFQEDGTLLLDGSSSMSPQDLTYMGTKTPLVNASLIQNIRYKNFELSAMFLYYGGHKMYRPSFAFNSTDGNEDWVAKSWTPENTSSTVPKAPIYYEPNISVVNLGSLAGMYIRSTENVVKGDFIRLRNISLSYHLPQVFPHSLKIERVKITGQINNPWIWSAAGKSIDAEIQSSASNTASLSNWALPTAKSYFIRLDIIF
>NZ_CP009278.1|WP_051960168.1|4958191_4958440_+|DUF4974-domain-containing-protein
MDAATIAAWKEGIFSFNNTDIREVLRQLSRWYNIQVVFRGKVPDRKFSGGFERQANLEQVIQILKESNINCIVKDNKLVIYD
>NZ_CP009278.1|WP_051960167.1|4957237_4958134_+|FecR-domain-containing-protein
MDVENLYFKFLAGTCSDAELRLLLEHFESEEQRSTLASKITATLQESTEISDPALKKRVDKLLVQTDSYFEALLQESKQPPLDRSNTSVGTFRYWKYYAAAAALIVCAITGILFWQHYHLAENRNATTLELKKFSPGTDKAILTLADGKQIILLPSGQDTISKGRSINMLNGRDGLTVTAQSKEDNPILTAFNTLSTPNGTQYKLQLADGTKVWLNAGSSLKFPSVFKGKTRQVELTGEAYFEVAHRADCPFSVTLPKLKVEVLGTHFNVKAYPNESNIETTLLQGAVKVSTKDRAVL
>NZ_CP009278.1|WP_051960165.1|4956482_4957115_+|RNA-polymerase-sigma-70-factor
MPKISLLRGKGSPHVTYPINENDLLQRLIDGDHAAFETIYHHYKQQLAVNLLKLLKDDDLATDALQDLFTRVWKNRSSIDINQSFKAYLYRIAKNLVIDYYRKAAHDKTLYDLLLQSTDWYSPIEEQLIKKENKEIFESLLNKLPPQQRRAFELHKLKGKSYKEIVEIMGITPTTINKHIYQASQSIKEQVLKSPHLFRAILIPVILAYL
>NZ_CP009278.1|WP_144243376.1|4955757_4956012_+|hypothetical-protein
MPASQVTPQVKLLIVTLTDDRSRKELQSQLNLSDREYFRLHFLQPAIELGFIGMTIPNKPKSSNQKYFLTEMGKEIRNQLLNET
>NZ_CP009278.1|WP_038703156.1|4954268_4955288_+|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MKLHNDIKLFRQSIDFTAQQMGILPIYVEKDYWVTYALHLIFQDSIGTETVFKGGTALSKCFGLIERFSEDIDLVVLKQEGEGANQLKNKLKKITNLVGTKLTEVNEEGITHKVGMLRKIAYSYPKTTTGKYGQVRENIIVEATWLGRYEPFHKTTISSYIFKMMESTGQYQLAEQHHLLPFEVQVLHVNRTICEKIMSLVRFSYGEHPITDLRNKIRHTYDLHQLLQVPEILEFFESSKFEEMLLLVGEDDVASFKNNNQWLELHPKEAKIFRETEETWKELENTYTNEFGNLVYGALPNSEAVLDSLIGIRERMKNVKWDIIIPNLPKPADKDKGEG
>NZ_CP009278.1|WP_038701465.1|4953546_4954272_+|hypothetical-protein
MKTTEYIANTIDRLPKGYVFTYTDFITEVNKKQAVIKALNRMAVSGKIAKLAKGKYYKPENTPFGNLEPSQFQVVKDLLEDDGKTIGYLTGYSIYNQLGLTSQVSNTIQIGRNEIRPVLQRDRYIIKFIKQKNTITKENIPLLQLLDAIRYIKKIPDSDASSACLRFITLLKNLSEKEINTLVRLSQKYPPATRALLGALLEEIGVMQFQEVLQKSLNPITKYKRSGVDRVLKASEKWNLL
>NZ_CP009278.1|WP_038701473.1|4967617_4968007_-|hypothetical-protein
MHFLFFLKSFIFIQDETINTNFDSYIYEVSGGAINMGVIEIIKKQEREAGMSAGLAAGIEKGLEERAKIAAEKKRIAAEKHALELKLQTLLEEAHEQACESARKMLARGTGKEEISEILGLSLAEIEKL
>NZ_CP009278.1|WP_038701475.1|4968120_4968651_-|hypothetical-protein
MNSGQTNLGGLPRKQNDELLKGVFEENFQDFLQFMYPNAKEIFDFDRGFSFKNKELFKIIPDRERSDGKRIADLLAKVYLKDGTEKWIMVHTEIEGGNSSDFAHRIYQYHYRIRDKFDVPVETIAVFTGDRKQRRPCEYLELGIHTSIHSSICRIKFLTTRRPNFSIVTISLLILL
>NZ_CP009278.1|WP_158500329.1|4969977_4970388_+|hypothetical-protein
MFIIDIRWIFKILFNLAIIIIIGRLFYAPYEPKLQGTNLVYILPCIGLLSSYLYLAVWFGWKKGFKILCYVAGYFLFTGYFALRDSLPKWLDYTITVAILSLIGYGCYRIIKFLINLVKNLKMRFEAYRMRNKNRR
>NZ_CP009278.1|WP_038701479.1|4971822_4972137_+|transposase
MSRERKVYTKEFKLMSVELSNTRNDLTALSKELDITPSLLYRWRKEYSSKPDTSFPGNGKVILTEAEQEVARLKKELRETQMERDILKKAVSIFSKSYGKYSGS
>NZ_CP009278.1|WP_144243378.1|4972121_4972646_+|IS3-family-transposase
MFGFIKNHSRIFSIGKMCSVFNVSRGGYYTWLKRVPSRRSIENQMLEQEILEAFQNSKYRYGSPRITRALNKKRIKVSRPRVAKIMKRNHLRSIVKKKFKVTTDSSHKFTVPANKLDRNFKPDTLGAAWVSDITYIRTKQGWLYLTTVIDLGDRKVIGWALSATGSATFEWTSS
>NZ_CP009278.1|WP_051960177.1|4972672_4973044_+|transposase
MSQERKTYPKEFKLMSVELSNTRTDLSALAKELDISPAMLYRCGKVILSAAEQELSLLKKELRETQMEHGILNYLDTGYTGGCGTSQKRLSAFSARETTNIRVHKGSLQNIFSCEDVFSIKSE
>NZ_CP009278.1|WP_081918452.1|4973106_4973280_+|IS3-family-transposase
MKPRFLQAFENSKKKYGSPRITLELHKKAISVSRPRVTRIMKKAKLRSIEKYSEEKI
>NZ_CP009278.1|WP_158500330.1|4974034_4974244_+|hypothetical-protein
MSFSPAVSQKKLTLMRTKLKNHPVIKGCYSVSLEEYAKNINPVIQGWINYYGKFRKSSLNSFIGISMIS
>NZ_CP009278.1|WP_081918454.1|4974632_4975049_-|Fur-family-transcriptional-regulator
MKNTLAKTEIFNLISNASVALSHSEIEKSLVGLCNRVTIYRVLERLEEEGHIHKFINIDGHLKFADCRNCKDHLHHNHAHFSCVECGTVTCLEKVEPIYKMPAQYQVQKLNFTLSGICPSWNCNNKVDIRLSCNILFV
>NZ_CP009278.1|WP_051960181.1|4975460_4976705_+|GTP-binding-protein
MQGQSLIPKSEQFVGNRKLPVTVLSGFLGAGKTTLLNHILHNKDGLKVAVIVNDMSEVNVDVRLVENENTLSRTEEKLVEMSNGCICCTLREDLMVEVEKLAEEGRFDYLLIESTGISEPIPIAQTFSYVDEENGIDLSRFSYIDTMVTVVDCFNFFKDFGTNQLLQDRDLTDIEGDYRTIVNLLIDQIEFANVIILNKTDLVDKDTLGVLKASIRKLNPEAKLINSEFSKVDPKEILNTKLFNFEDAQTSAGWQKELEAESHTPETEEYGITSFVFRNQKPFHPERFWSYLNTDYPNGIIRAKGLFWLASRPNNALNFSQSGGSSRLESAGVWWCSMPYSERINYTPFLENEDIIEERWSKQWGDRLNELVFIGQHIDKETVIVDLEKCLLQIDEQYLFDENFKFEDPFPKDI

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Crispr_ID: NZ_CP009278_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009278_4

5146180-5146329

Orphan

Consensus_repeat	Method
TAGTAGTAACACAGTAACAACAGTGACGCAGTAACATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009278_4

>merge|NZ_CP009278|4|5146180-5146329|CRISPRCasFinder
TAGTAGTAACACAGTAACAATAGTGACGTAGTAACACTAGTAGTAACACAGTAACAACAGTGACGCAGTAACATTAGTAGTAACGTAGTAACAATTAGTGACGTAGTAACATTAGTAGTAACACAGTAACAACAGTGACGTAGTAACATT

>NZ_CP009278|4|4|5146180-5146329|CRISPRCasFinder
TAGTAGTAACACAGTAACAATAGTGACGTAGTAACACT	AGTAGTAACACAGTAACAACAGTGACGCAGTAACATTAGTAGTAACGTAGTAACAATTAGTGACGTAGTAACAT
TAGTAGTAACACAGTAACAACAGTGACGTAGTAACATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009278.1\|WP_038701719.1\|5137639_5138149_-\|HAD-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|319769
NZ_CP009278.1\|WP_038701717.1\|5136194_5137643_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240533
NZ_CP009278.1\|WP_038701729.1\|5145550_5146111_-\|dTDP-4-dehydrorhamnose-3,5-epimerase	unknown	unknown	gnl\|CDD\|376414
NZ_CP009278.1\|WP_038701737.1\|5152563_5152833_+\|PqqD-family-protein	unknown	unknown	gnl\|CDD\|377508
NZ_CP009278.1\|WP_038701727.1\|5144694_5145564_-\|dTDP-4-dehydrorhamnose-reductase	unknown	unknown	gnl\|CDD\|367904
NZ_CP009278.1\|WP_038701723.1\|5141032_5143549_-\|capsule-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224512
NZ_CP009278.1\|WP_038701731.1\|5146355_5147417_-\|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|224013
NZ_CP009278.1\|WP_038701739.1\|5154501_5155419_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275080
NZ_CP009278.1\|WP_038701725.1\|5143583_5144444_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl\|CDD\|130274
NZ_CP009278.1\|WP_038701735.1\|5149747_5150173_-\|adenylyltransferase/cytidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|173922
NZ_CP009278.1\|WP_051960211.1\|5139206_5139944_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133011
NZ_CP009278.1\|WP_038701736.1\|5151127_5152033_+\|DUF5106-domain-containing-protein	unknown	unknown	gnl\|CDD\|375005
NZ_CP009278.1\|WP_038701734.1\|5148523_5149522_-\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|223906
NZ_CP009278.1\|WP_038701733.1\|5147569_5148046_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038701721.1\|5139950_5141021_-\|LPS-biosynthesis-protein	unknown	unknown	gnl\|CDD\|367147
NZ_CP009278.1\|WP_038701738.1\|5152857_5154489_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP009278.1\|WP_051960213.1\|5152046_5152499_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119396
NZ_CP009278.1\|WP_038703212.1\|5138157_5139201_-\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|274655
NZ_CP009278.1\|WP_038703214.1\|5150272_5150695_-\|adenylyltransferase/cytidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|140329
NZ_CP009278.1\|WP_038701715.1\|5135313_5136195_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP009278.1\|WP_038701719.1\|5137639_5138149_-\|HAD-hydrolase-family-protein	gnl\|CDD\|319769	cd01630, HAD_KDO-like, haloacid dehalogenase-like (HAD) hydrolase, similar to Escherichia coli 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) phosphatase KdsC, and rainbow trout N-acylneuraminate cytidylyltransferase. KDO 8-P phosphatase catalyzes the hydrolysis of KDO 8-P to KDO (3-deoxy-D-manno-octulosonate) and inorganic phosphate and is the last enzyme in the KDO biosynthetic pathway. KDO is an 8-carbon sugar that links the lipid A and polysaccharide moieties of the lipopolysaccharide region in Gram-negative bacteria. An interruption in KDO biosynthesis leads to the accumulation of lipid A precursors and subsequent arrest in cell growth. The KDO biosynthesis pathway involves five sequential enzymatic reactions. This family also includes rainbow trout CMP-sialic acid synthetase which effectively converts both deaminoneuraminic acid (KDN, 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) and N-acetylneuraminic acid (Neu5Ac) to CMP-KDN and CMP-Neu5Ac, respectively. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.93066e-57
NZ_CP009278.1\|WP_038701717.1\|5136194_5137643_-\|hypothetical-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	3.66855e-10
NZ_CP009278.1\|WP_038701729.1\|5145550_5146111_-\|dTDP-4-dehydrorhamnose-3,5-epimerase	gnl\|CDD\|376414	pfam00908, dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. This family catalyze the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	2.65282e-95
NZ_CP009278.1\|WP_038701737.1\|5152563_5152833_+\|PqqD-family-protein	gnl\|CDD\|377508	pfam05402, PqqD, Coenzyme PQQ synthesis protein D (PqqD). This family contains several bacterial coenzyme PQQ synthesis protein D (PqqD) sequences. This protein is required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis.	2.2387e-12
NZ_CP009278.1\|WP_038701727.1\|5144694_5145564_-\|dTDP-4-dehydrorhamnose-reductase	gnl\|CDD\|367904	pfam04321, RmlD_sub_bind, RmlD substrate binding domain. L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesized by four different enzymes the final one of which is RmlD. The RmlD substrate binding domain is responsible for binding a sugar nucleotide.	5.80073e-115
NZ_CP009278.1\|WP_038701723.1\|5141032_5143549_-\|capsule-biosynthesis-protein	gnl\|CDD\|224512	COG1596, Wza, Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis].	4.93324e-22
NZ_CP009278.1\|WP_038701731.1\|5146355_5147417_-\|dTDP-glucose-4,6-dehydratase	gnl\|CDD\|224013	COG1088, RfbB, dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane].	0
NZ_CP009278.1\|WP_038701739.1\|5154501_5155419_+\|hypothetical-protein	gnl\|CDD\|275080	TIGR04249, SCM_chp_ScmC, SynChlorMet cassette protein ScmC. A biosynthesis cassette found in Syntrophobacter fumaroxidans MPOB, Chlorobium limicola DSM 245, Methanocella paludicola SANAE, and delta proteobacterium NaphS2 contains two PqqE-like radical SAM/SPASM domain proteins, a PqqD homolog, and a conserved hypothetical protein. These components suggest modification of a ribosomally produced peptide precursor, but the precursor has not been identified. Members of this family are designated ScmC.	0.000401207
NZ_CP009278.1\|WP_038701725.1\|5143583_5144444_-\|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl\|CDD\|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	2.07399e-174
NZ_CP009278.1\|WP_038701735.1\|5149747_5150173_-\|adenylyltransferase/cytidyltransferase-family-protein	gnl\|CDD\|173922	cd02171, G3P_Cytidylyltransferase, glycerol-3-phosphate cytidylyltransferase. Glycerol-3-phosphate cytidylyltransferase,(CDP-glycerol pyrophosphorylase). Glycerol-3-phosphate cytidyltransferase acts in pathways of teichoic acid biosynthesis. Teichoic acids are substituted polymers, linked by phosphodiester bonds, of glycerol, ribitol, etc. An example is poly(glycerol phosphate), the major teichoic acid of the Bacillus subtilis cell wall. Most, but not all, species encoding proteins in this family are Gram-positive bacteria. A closely related protein assigned a different function experimentally is a human ethanolamine-phosphate cytidylyltransferase.	1.54123e-17
NZ_CP009278.1\|WP_051960211.1\|5139206_5139944_-\|hypothetical-protein	gnl\|CDD\|133011	cd02518, GT2_SpsF, SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat. Spore coat polysaccharide biosynthesis protein F (spsF) is a glycosyltransferase implicated in the synthesis of the spore coat in a variety of bacteria challenged by stress as starvation. The spsF gene is expressed in the late stage of coat development responsible for a terminal step in coat formation that involves the glycosylation of the coat. SpsF gene mutation resulted in spores that appeared normal. But, the spores tended to aggregate and had abnormal adsorption properties, indicating a surface alteration.	6.4107e-55
NZ_CP009278.1\|WP_038701736.1\|5151127_5152033_+\|DUF5106-domain-containing-protein	gnl\|CDD\|375005	pfam17127, DUF5106, Domain of unknown function (DUF5106). This domain, found in Bacteroidetes proteins, is frequently associated with a putative thiol-disulfide oxidoreductase domain, pfam13905. The function of this domain is not known.	2.70508e-33
NZ_CP009278.1\|WP_038701734.1\|5148523_5149522_-\|NTP-transferase-domain-containing-protein	gnl\|CDD\|223906	COG0836, {ManC}, Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane].	6.92532e-119
NZ_CP009278.1\|WP_038701721.1\|5139950_5141021_-\|LPS-biosynthesis-protein	gnl\|CDD\|367147	pfam02706, Wzz, Chain length determinant protein. This family includes proteins involved in lipopolysaccharide (lps) biosynthesis. This family comprises the whole length of chain length determinant protein (or wzz protein) that confers a modal distribution of chain length on the O-antigen component of lps. This region is also found as part of bacterial tyrosine kinases.	5.41616e-06
NZ_CP009278.1\|WP_038701738.1\|5152857_5154489_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.7194e-89
NZ_CP009278.1\|WP_051960213.1\|5152046_5152499_+\|hypothetical-protein	gnl\|CDD\|119396	cd06462, Peptidase_S24_S26, The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases.	1.13514e-06
NZ_CP009278.1\|WP_038703212.1\|5138157_5139201_-\|shikimate-dehydrogenase	gnl\|CDD\|274655	TIGR03569, ORF_8_similar_to_NeuB_family, N-acetylneuraminate synthase. This family is a subset of the pfam03102 and is believed to include only authentic NeuB N-acetylneuraminate (sialic acid) synthase enzymes. The majority of the genes identified by this model are observed adjacent to both the NeuA and NeuC genes which together effect the biosynthesis of CMP-N-acetylneuraminate from UDP-N-acetylglucosamine.	2.76493e-83
NZ_CP009278.1\|WP_038703214.1\|5150272_5150695_-\|adenylyltransferase/cytidyltransferase-family-protein	gnl\|CDD\|140329	PTZ00308, PTZ00308, ethanolamine-phosphate cytidylyltransferase; Provisional.	1.25587e-16

>NZ_CP009278.1|WP_038701729.1|5145550_5146111_-|dTDP-4-dehydrorhamnose-3,5-epimerase
MKSIETKLKGCFILEPTVYEDERGYFFEAYNEEKFAQILGNKPHFVQDNQSQSQYGVVRGLHMQAGDHAQAKLVRVMEGKVIDVAVDVRPGSETYGQSVAVELSAENKRQLYVPRGFLHGFSVLSETAVFFYKCDNQYHQASEDGVFPLDQEFDIDWGVPEADMILSQKDQTAQTFASFKEKHDIG
>NZ_CP009278.1|WP_038701727.1|5144694_5145564_-|dTDP-4-dehydrorhamnose-reductase
MTSVNQNQRILVTGATGQLGNELKVILEQDLSKECYFLDRKQLPLDQIMLIQDILAMYQPDVIVHAGAYTAVDLAESEPVLADQVNHLATDEIAQYCRLHGKQLIAISTDYVFDGNSSTPLTEDAAVSPINVYGETKLKGEQAIQKWCPEAIIIRTSWVYATHGKNFVKTMLRLMSERDSISVINDQIGSPTSAHDLAKAIVTIITSDKWEGGLYHYSNEGEISWYDFAVAIRELKQLDCDIKAIPSTAYPTPAKRPHYSLLDKTKIKTVYGVEVPFWRDSLAACLDSL
>NZ_CP009278.1|WP_038701725.1|5143583_5144444_-|glucose-1-phosphate-thymidylyltransferase-RfbA
MKGIILAGGSGTRLHPMTLAVSKQLMPVYDKPMIYYPLSTLMLAGIHEILIISTPQDLPQFQRLLGDGSQLGCRFEYIEQPSPDGLAQAFILGEEFIGDDKVALILGDNIFHGSGMSHLLQSCVDVEGGMVFAYQVNDPERYGVVEFDANKVAVSIEEKPLSPKSNFAIPGLYFYDNDVVEIAKQIKPSPRGELEITDINKVYLERGKLKVSVFDRGTAWLDTGTIQSLMQAAQFVQVIEERQGMKIGAIEEVAYRMGYIDKDQLLKVADPLRKSGYGEYLRLLIK
>NZ_CP009278.1|WP_038701723.1|5141032_5143549_-|capsule-biosynthesis-protein
MKRLLLWIFVIGLMSSVQAQTNPTNIKVDDLSDAQIEQYVKQAALMGYGESQLDGFARAQGVSAVEAQKLKDRLQKIKRTKQTPKQLQDNRISNSTTGRQVNGGSEQDTLRSNNNQDSLLIDEKKLKIFGSDLFKNNAITFEPNLRMATPSSYIIGPDDEILLDISGDNEASYKLPVSADGTIKVEYVGAINVSGLSIAAAKSKIQQRLSSTYSAIRSGMTHVDVNIGNIRTIRITLTGATTKPGTYSLPSLATVFNALYAAGGPSETGTYRQIQVIRNNQVVTTIDLYDFLANGIQSGNVRLQDQDIIHIPVYGSRVQFEGEVKRPAIFETVSGESLLDLVKYAGGFSEDAYTAKIKVLQKTDKERSVKDIYADQFADYSPKAGDQFIIEPILERFANRVSVLGAVFRPGLYGMEPGMTLKQLLEQADGVREDAFLERGIINRLRADNTAELINFNVREILAGTVEDIPLKREDKIEIASIFDLRDEYKFTVQGEVRLPGDFPFASNATLGDLIQKAGGLNEAAKNARIEIARRLNNREVGDTTSSQTILVDINGGIVSDLNIALQPYDVISVLGDAGFRTQRQVKIEGEVLYPGIYTISREDERISDIIKRAGGLTSYAYTEGASLKRTGLSKLKAEEKKEKERLKKEMRKNSDENQDTEDGEFDNEDGLTSSNPNAKNNALAKVSQQQGVSAPDIEPSDLVGIELNKILANPDQRGDLLVLDGDIITVPKELETVKVMGEVLNPNNVVYVKGKNLKYYVNQAGGFTDNALKKRVFVQYANGAVKGKDGGYPEVKPGAEIVVPKRAPREKISSQAWIGIGTGVASTLAIIISLFKN
>NZ_CP009278.1|WP_038701721.1|5139950_5141021_-|LPS-biosynthesis-protein
MNKTNEISLKELILIIKDWISFLLKKWFLFIISILVGASIGFLYSKFKAPSFTATTTFVLESGEAGGGGGLAQYAGIASMVGVDLGGSGGGIFQGDNLLELYKSRKMIQAALLASSDSDKNHLLIDLLLMENGKLNRWEKQNSDLVNIEFHLIKQKNSLLQRKKDSVLMEAVADINNKYLSVSKPDKKLSIIKVDVTSKNEVFSKEFNNALVKKVNDFYVQTKTKKSLNNIAILQHKTDSVRSVMNGNISTAAVILDATPNLNPTRQAQRLVPTQRSQFSAETNKAILGQLVQNLELSKMALLKEAPLIEEIDSPIYPLKIERVGALKGIVFGAALSSLFMFFLLVIYRIYKTALN
>NZ_CP009278.1|WP_051960211.1|5139206_5139944_-|hypothetical-protein
MIGIIIQARLGSTRFPKKILKKFGSETILSFLINRLLVLNIPIVVATTDNIVDDELCEYLILNNISFYRGSEDNVLQRFIETANSYDFDKIIRICSDSPFIDVDKMIDLIKTSENIDFDYLSYSYQSLPTVLCHFGVFTEIVKRSALIKLNDTYNLPDYCEHVTFGLYKNPDNFNIRLLALPESYSKYEKIRLSLDTESDYLNLLEVEKALGNDFNSSFENIAEYIINDNKLIASMELNIINNKK
>NZ_CP009278.1|WP_038703212.1|5138157_5139201_-|shikimate-dehydrogenase
MSKEVYVIGEIGQNHNGSVDLAKLIIDLACRPVEEDLFNLQLKPMNAVKLTKRDLKQELSKSQMNAAYNSPYSFGATYGVHREVLELNDEEHFEIYKYAKAKGIDFVETLCAVGCLSLLRYFEPDYLKVASRDLTNLPLLEALAETKIPIIVSTGMAGKKELDDAITVIAKYHSNLSILHCVSQYPTHPKNVNLNTIKFLKNNYKDYRVGYSDHTIGISTPLAAVAMGAEIIEKHITIDRRMKGTDQAGSLGPDGVNRMVRDIRMLERSLGIEDIFIDSDVSGAKNKLERSIATKRLMKKGEVIKEEDLQMLSPGDGIKWADREELLGRELNCDIPADEVIYKTFVL
>NZ_CP009278.1|WP_038701719.1|5137639_5138149_-|HAD-hydrolase-family-protein
MKLPKLIATDIDGVWTDGGMYYDQLGNEWKKFNTLDSAGVLFAKYMEIPVVIITGEDTAIVKRRAEKLKIEHLYMGVKNKLEVLQSICDSLDIHLDDVAYIGDDLNDMEVLQHVGFSSCPSSASFYIQELCDHICKSRGGDGVFREFVEHIIGVEQLKKIVHNIKLNIQ
>NZ_CP009278.1|WP_038701717.1|5136194_5137643_-|hypothetical-protein
MIGIFKKLNSSLIFILSKYMIYGLQFLNAFFIAFKLGPYYLGVWGFANLVFQYFDQLNLGISHSVNVICSTTKEKKKYISLVVGNSMFLLFLLSIVAIITYSILVIEYDLGSKYQISKYLLVSIIVFSTAYFNSLLTNVVRVYGAINQITIAQAIFPITTSVLLFLFKEERLLDLLLMCYAIVNLFILFFLYLSLPIRISFNLSLRLQKSVLRLALPLFFYNTFFYLIFISTRTFVSSYYSVEDFGYFTFTFSLANIIVLLSESFSFLIWPKLINRFKQFSIDASKQLLVKIRTIYLIFSHLCFYIALLLYPLLSVYFGQFNDTYQSFSLSLVVVTLLSNSFGLQGFLIAKGAQNFLALTSLFSLILNIALGFILIYYYQVTYYNVLIATSIAYLTFNFVLAIKVCKFLFLPEDRLLNVLRIGFDISILVPFFIAVIIIIMDLHFLMILIPLFAFFVLNIKKMLFSIRNIKMLFQNPDIFNI
>NZ_CP009278.1|WP_038701715.1|5135313_5136195_-|hypothetical-protein
MRKNYYLVTTPLQYCNAINISTEGINILIFLSDFEGANTLFDRIRNSTYWDSTYSFSTYNQAFEFINRNVSIEDYLYIDSDYGMRTALKLRKIKTKEIFVYEEGTGTYRSDLISATHPNKILVMLLKFFGVSEYFGGSRFVKGLYMYDVAKHEKLVPDFHKTRLRFRRSFLDNLELIKMDLISKEQRDFYKKLVAGRDVHLYLTNWNYNIKIDKILTDNRNEMKNENALYLLKPHPRLINSEFEFVYDSILSNSALVEILLIDFKKFSKSLTVYHEGSSALLYLTDINQKRID
>NZ_CP009278.1|WP_038701731.1|5146355_5147417_-|dTDP-glucose-4,6-dehydratase
MNRTIIITGGAGFIGSHVVRNFVNKYPEYHIINLDALTYAGNLENLRDIEEKPNYTFVKEDITDAAAMIRVFEQYQPDGVIHLAAESHVDRSIADPTAFVMTNVIGTMNLLNAARAIWEGQFEGKRFHHVSTDEVYGALGDTGLFTEETAYDPHSPYSASKASSDHFVRAYHDTYGLPIVLTNCSNNYGPNHFPEKLIPLCIHNILTNQPLPIYGDGKYTRDWLYVVDHAVAIDLVFHEGKNGGSYNVGGFNEWQNIDLVKELCKQVDEKLGRPTGTAEALITFVKDRPGHDLRYAIDANKINKELGWYPSVTFEEGLSKTIDWFLDNQEWLDNVTSGDYQKYYEEQYKEVKK
>NZ_CP009278.1|WP_038701733.1|5147569_5148046_-|hypothetical-protein
MLILVLIIFLFIGCYYFWAARQRNQRFANHGQMSVSYLFQERPGQYSGDRSIKSGVLVIHSRSHDEKLKHATIKHVHLQHPDLRIHLEQSLALPFQHDEVSKPEVSVRYKVIKNDIDTVDLTGVNTTIAGKLHFVSGASKTFKVTVPISGLYQEQGQN
>NZ_CP009278.1|WP_038701734.1|5148523_5149522_-|NTP-transferase-domain-containing-protein
MSDIIHVILSGGVGSRLWPLSRKSYPKQYLSLFKEGSLFEMTVKRNQGFCNQVIVVGNKDNNQLSRQVMESSGVDYIDIVESTPRNTAAAIAFAAFAANPDDILVVTPSDHVIVGEDAYNQAIEEAIVKANQGYIVTFGIQATKPETGYGYIEFEGDQVVSFREKPNKETAEDFIERGNFLWNSGMFCFRADTLLHELQQFEPRVYATALAAWQHKKDGILDEALSKEIPSISIDYAVMERSKKIRVVATDFTWSDLGSFESMYDYLKETGHPTDENGNMVIGTDIFSAFVGLKNTILVYTNDAFLVLQKESSQDVKKIYNTLERHQSKLID
>NZ_CP009278.1|WP_038701735.1|5149747_5150173_-|adenylyltransferase/cytidyltransferase-family-protein
MKIGITFGVFDLLHAGHIMMLEEARRNCDHLIVGLNTDPSEVSPDKAKPTQTVVERYIQLEGCRYVDEIIPYETEQDLTDIIKALPIQVRIIGEEYRDMEFTGKKYCIEEGIEIYYNKRSHRFSSEGLRKVVAAKEAEKIG
>NZ_CP009278.1|WP_038703214.1|5150272_5150695_-|adenylyltransferase/cytidyltransferase-family-protein
MRVGITFSAFDLLHAGHIKMLEDARRQCDYLICGLQTDPTLDRPEKNKPTQTVVERYIQLKGCKYVDQIVPYATEQDLEDVLRSFKVDVRIVGDEYRERDFTGRQYCEESGIALYFNSRDHRFSSSGLRRIVAEHEVEKG
>NZ_CP009278.1|WP_038701736.1|5151127_5152033_+|DUF5106-domain-containing-protein
MKCTTFKIWFFLGAITLLSVSCNQHSKSEKQNADNDIKKEHYTAADSAVLTYWDKFDMADTVKIKDPNMGEQKLADFIAALNTVSDTVADHAIANMLDGTKASKVGFDHFIKLYEHYLYDGNSPMRNDVRYESVLRYLIQTDRLSDLEKEAYRPIYKLVQRNKLGKKAEEFDFERSDGQVQKLSDVKAKYTLLLFYDTECTHCKETLDLLKDTPQLVQLFEQKQVQVLAIEPWGDRPKWKGYQSHLADNWINGFDRESTIQHERLYDLKASPTLYLLDENKNVLLKDTQLQELIQYLIRLI
>NZ_CP009278.1|WP_051960213.1|5152046_5152499_+|hypothetical-protein
MKKTESMTISNALYFEEVQRLLEEGKEVCIRVKGNSMLPFIKSGDRVLLVAYQGEPLPKGANILAKHEGNYIFHRYVGKKGDKYLLAGDGNLVLHEYIAEKDILALATRHYPTSGDETIAIDKPLYRFRGMAWYYMRIIRKIITVLKRRF
>NZ_CP009278.1|WP_038701737.1|5152563_5152833_+|PqqD-family-protein
MKLRADLVLRTIGSDHMIVDPGQEMVDLSTVYTLNDTAAWLWEQLQGIDFTIASIVELLCQQYEVTEQQALADAETLIKDFEKQGLLEK
>NZ_CP009278.1|WP_038701738.1|5152857_5154489_+|ABC-transporter-ATP-binding-protein
MSNNNLRHHTRWAWSISKGYRARLLFYFILELFAIALSLLFVFLSKKAVDIATATTADISLTWILIGIVGSVLLGLGIRAYTGWLNERIKMMLTLELQRNMLDAQMLSVWKLIKNWHTGDIQIRIQTDCEEVANLIAKSLLSFILTAIQLLASLGFLWYMDPMLALMILAISPLFLFSKIYFQKMRKLSQEVKGEESNFSNVLQENLRFRLLIRAMGIFPKRRKKLTDSQQELFALKMKQLNFSTYTQSVMKLSLNAGYLLTFIWGIYRLHSGQISFGTMTAFLQLVARIQSPILALITFIPGFVRFRVSADRLLELKDGEIEPLVEQKRLNKISALQIQNLSFRYEDKWVLDQFNLNLKAGEPTAIVGPSGKGKTTLIRLLLSLIKPEKGEILLTDRDGIHVLTAAHRINFAYIPQGNSLLSGTIRENLLLHVKDGGHIAIEKALRIACAEFVLELPDGVDTVVGESGMGLSEGQAQRIAIARALMHDGDIWLFDEVTSALDRKTADLLIQRLLEYGHDKLCLFVTHDLSLVDKCKHHIYLD
>NZ_CP009278.1|WP_038701739.1|5154501_5155419_+|hypothetical-protein
MTLKNPIEISQNYYKIADLIVKINYPDTLNLENLLPSFRVFQIDNTNEKPALSILLSTDKAPATADMGILRSDESIAWGDRFCFYEREDSFLTTIVNDQGNEQWCMRSERNFSQSTIYIPSSTEGECSSVIWWMLMMVFGQAALLHDTIMIHASVINCNGQGIAFLGKSGTGKSTHSRLWLKHIPNTDLLNDDNPAIRISPDGIHIYGTPWSGKTHCYKNEKINLKAFVRLQQAPSNLFKWQSGVSSFITVLPSCTAIRWNKDLFATMNSTLEKVVSQVPVGLLQCLPDEAAAQLCYNRIFNKPE

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Crispr_ID: NZ_CP009278_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009278_5

5156975-5157059

Orphan

Consensus_repeat	Method
TAATCTGTTCTTTAATGGTCATTCATGC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP009278_5

>merge|NZ_CP009278|5|5156975-5157059|CRISPRCasFinder
TAATCTGTTCTTTAATGGTCATTCATGCGATCACGAACTGCGTACCTTATCAATTTTTAATCTGTTCTTTAATGGTCATTCATGC

>NZ_CP009278|5|5|5156975-5157059|CRISPRCasFinder
TAATCTGTTCTTTAATGGTCATTCATGC	GATCACGAACTGCGTACCTTATCAATTTT
TAATCTGTTCTTTAATGGTCATTCATGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009278.1\|WP_038701747.1\|5166809_5167547_-\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|366780
NZ_CP009278.1\|WP_038701743.1\|5160684_5161992_-\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NZ_CP009278.1\|WP_038701737.1\|5152563_5152833_+\|PqqD-family-protein	unknown	unknown	gnl\|CDD\|377508
NZ_CP009278.1\|WP_051960213.1\|5152046_5152499_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119396
NZ_CP009278.1\|WP_038701738.1\|5152857_5154489_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP009278.1\|WP_038701745.1\|5163952_5165377_-\|arylsulfatase	unknown	unknown	gnl\|CDD\|293764
NZ_CP009278.1\|WP_038701735.1\|5149747_5150173_-\|adenylyltransferase/cytidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|173922
NZ_CP009278.1\|WP_038701736.1\|5151127_5152033_+\|DUF5106-domain-containing-protein	unknown	unknown	gnl\|CDD\|375005
NZ_CP009278.1\|WP_038701742.1\|5160005_5160533_-\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NZ_CP009278.1\|WP_038701734.1\|5148523_5149522_-\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|223906
NZ_CP009278.1\|WP_158500339.1\|5155454_5156969_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|143477
NZ_CP009278.1\|WP_038701733.1\|5147569_5148046_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009278.1\|WP_038701739.1\|5154501_5155419_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275080
NZ_CP009278.1\|WP_038703216.1\|5169971_5171681_-\|glycoside-hydrolase-family-3	unknown	unknown	gnl\|CDD\|366376
NZ_CP009278.1\|WP_038694773.1\|5157323_5158499_+\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|372999
NZ_CP009278.1\|WP_144243388.1\|5165646_5166750_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP009278.1\|WP_144243389.1\|5167771_5169892_+\|carboxy-terminal-processing-peptidase	unknown	unknown	gnl\|CDD\|236873
NZ_CP009278.1\|WP_038701744.1\|5162213_5163791_+\|DUF3843-family-protein	unknown	unknown	gnl\|CDD\|315605
NZ_CP009278.1\|WP_038703214.1\|5150272_5150695_-\|adenylyltransferase/cytidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|140329
NZ_CP009278.1\|WP_144243387.1\|5158912_5159449_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP009278.1\|WP_038701747.1\|5166809_5167547_-\|dienelactone-hydrolase-family-protein	gnl\|CDD\|366780	pfam01738, DLH, Dienelactone hydrolase family.	7.5256e-35
NZ_CP009278.1\|WP_038694773.1\|5157323_5158499_+\|IS4-family-transposase	gnl\|CDD\|372999	pfam14294, DUF4372, Domain of unknown function (DUF4372). This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with pfam01609. There is a single completely conserved residue G that may be functionally important.	3.47898e-22
NZ_CP009278.1\|WP_038701737.1\|5152563_5152833_+\|PqqD-family-protein	gnl\|CDD\|377508	pfam05402, PqqD, Coenzyme PQQ synthesis protein D (PqqD). This family contains several bacterial coenzyme PQQ synthesis protein D (PqqD) sequences. This protein is required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis.	2.2387e-12
NZ_CP009278.1\|WP_051960213.1\|5152046_5152499_+\|hypothetical-protein	gnl\|CDD\|119396	cd06462, Peptidase_S24_S26, The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases.	1.13514e-06
NZ_CP009278.1\|WP_038701743.1\|5160684_5161992_-\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NZ_CP009278.1\|WP_038701738.1\|5152857_5154489_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.7194e-89
NZ_CP009278.1\|WP_038701745.1\|5163952_5165377_-\|arylsulfatase	gnl\|CDD\|293764	cd16145, ARS_like, uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	0
NZ_CP009278.1\|WP_038701735.1\|5149747_5150173_-\|adenylyltransferase/cytidyltransferase-family-protein	gnl\|CDD\|173922	cd02171, G3P_Cytidylyltransferase, glycerol-3-phosphate cytidylyltransferase. Glycerol-3-phosphate cytidylyltransferase,(CDP-glycerol pyrophosphorylase). Glycerol-3-phosphate cytidyltransferase acts in pathways of teichoic acid biosynthesis. Teichoic acids are substituted polymers, linked by phosphodiester bonds, of glycerol, ribitol, etc. An example is poly(glycerol phosphate), the major teichoic acid of the Bacillus subtilis cell wall. Most, but not all, species encoding proteins in this family are Gram-positive bacteria. A closely related protein assigned a different function experimentally is a human ethanolamine-phosphate cytidylyltransferase.	1.54123e-17
NZ_CP009278.1\|WP_038701736.1\|5151127_5152033_+\|DUF5106-domain-containing-protein	gnl\|CDD\|375005	pfam17127, DUF5106, Domain of unknown function (DUF5106). This domain, found in Bacteroidetes proteins, is frequently associated with a putative thiol-disulfide oxidoreductase domain, pfam13905. The function of this domain is not known.	2.70508e-33
NZ_CP009278.1\|WP_038701734.1\|5148523_5149522_-\|NTP-transferase-domain-containing-protein	gnl\|CDD\|223906	COG0836, {ManC}, Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane].	6.92532e-119
NZ_CP009278.1\|WP_158500339.1\|5155454_5156969_-\|hypothetical-protein	gnl\|CDD\|143477	cd07561, Peptidase_S41_CPP_like, C-terminal processing peptidase-like; serine protease family S41. Bacterial protease homologs of the S41 family related to C-terminal processing peptidase (CPP). CPP-1 is believed to be important for the degradation of incorrectly synthesized proteins as well as protection from thermal and osmotic stresses. CPP is synthesized with an extension on its carboxyl-terminus and specifically recognizes a C-terminal tripeptide, but cleaves at variable distance from the C-terminus. The CPP active site consists of a serine/lysine catalytic dyad. Conservation of these residues is seen in the CPP-like proteins of this group. CPP proteins contain a PDZ domain that promotes protein-protein interactions and is important for substrate recognition however, most of CPP-like proteins only have an internal fragment or lack the PDZ domain.	5.90972e-47
NZ_CP009278.1\|WP_038701739.1\|5154501_5155419_+\|hypothetical-protein	gnl\|CDD\|275080	TIGR04249, SCM_chp_ScmC, SynChlorMet cassette protein ScmC. A biosynthesis cassette found in Syntrophobacter fumaroxidans MPOB, Chlorobium limicola DSM 245, Methanocella paludicola SANAE, and delta proteobacterium NaphS2 contains two PqqE-like radical SAM/SPASM domain proteins, a PqqD homolog, and a conserved hypothetical protein. These components suggest modification of a ribosomally produced peptide precursor, but the precursor has not been identified. Members of this family are designated ScmC.	0.000401207
NZ_CP009278.1\|WP_038703216.1\|5169971_5171681_-\|glycoside-hydrolase-family-3	gnl\|CDD\|366376	pfam00933, Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain.	5.78493e-78
NZ_CP009278.1\|WP_038701742.1\|5160005_5160533_-\|3'-5'-exonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	3.9626e-72
NZ_CP009278.1\|WP_144243388.1\|5165646_5166750_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.00395403
NZ_CP009278.1\|WP_144243389.1\|5167771_5169892_+\|carboxy-terminal-processing-peptidase	gnl\|CDD\|236873	PRK11186, PRK11186, carboxy terminal-processing peptidase.	0
NZ_CP009278.1\|WP_038701744.1\|5162213_5163791_+\|DUF3843-family-protein	gnl\|CDD\|315605	pfam12954, DUF3843, Protein of unknown function (DUF3843). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	3.8165e-38
NZ_CP009278.1\|WP_038703214.1\|5150272_5150695_-\|adenylyltransferase/cytidyltransferase-family-protein	gnl\|CDD\|140329	PTZ00308, PTZ00308, ethanolamine-phosphate cytidylyltransferase; Provisional.	1.25587e-16

>NZ_CP009278.1|WP_158500339.1|5155454_5156969_-|hypothetical-protein
MKNTKLFPQQLIAKGVVFFLVALFFVSCKKSNPEPEPEPPPVERDANAMIRDSVYYYYKLYSLWADDYIPSYENPFEFTDKYRSAQSVLTALKGMTPAYPNYRDYGGVYDRFSFMEGLSGYDIGAQAKVKMDRADGYGLYFDMGTVDSKIAQPIIYFVEGGSPADNAGLKRSDIVLSINGESDYAVEIDCEGNDGCKAVDPSALGKIRSRLNSALEGGTLAIKVQHEDKTISNEELTYRTYTIDPIYKDSVYHYSSKNVGYLALSSFEEIENNNFNQVKVDGVFQKFEEQHIEDLVVDLRYNTGGYVDAAVYIANKIGGTKTDKKLMVTYKANAYMERAQKGPNGMFKDTYFSGGSSLNLRKVYFLVSETTASAAEMLINVLKPYFDVQVIATGTRTYGKPVGFFEQIIENKISFWPASFQLKNADGFSEYWDGLAADKSNVTDYIFLDSGNTAETMLETALEDAVPGSSVRASARRSARPDKGRVLQGNSINQLPEKGLLKSR
>NZ_CP009278.1|WP_038701739.1|5154501_5155419_+|hypothetical-protein
MTLKNPIEISQNYYKIADLIVKINYPDTLNLENLLPSFRVFQIDNTNEKPALSILLSTDKAPATADMGILRSDESIAWGDRFCFYEREDSFLTTIVNDQGNEQWCMRSERNFSQSTIYIPSSTEGECSSVIWWMLMMVFGQAALLHDTIMIHASVINCNGQGIAFLGKSGTGKSTHSRLWLKHIPNTDLLNDDNPAIRISPDGIHIYGTPWSGKTHCYKNEKINLKAFVRLQQAPSNLFKWQSGVSSFITVLPSCTAIRWNKDLFATMNSTLEKVVSQVPVGLLQCLPDEAAAQLCYNRIFNKPE
>NZ_CP009278.1|WP_038701738.1|5152857_5154489_+|ABC-transporter-ATP-binding-protein
MSNNNLRHHTRWAWSISKGYRARLLFYFILELFAIALSLLFVFLSKKAVDIATATTADISLTWILIGIVGSVLLGLGIRAYTGWLNERIKMMLTLELQRNMLDAQMLSVWKLIKNWHTGDIQIRIQTDCEEVANLIAKSLLSFILTAIQLLASLGFLWYMDPMLALMILAISPLFLFSKIYFQKMRKLSQEVKGEESNFSNVLQENLRFRLLIRAMGIFPKRRKKLTDSQQELFALKMKQLNFSTYTQSVMKLSLNAGYLLTFIWGIYRLHSGQISFGTMTAFLQLVARIQSPILALITFIPGFVRFRVSADRLLELKDGEIEPLVEQKRLNKISALQIQNLSFRYEDKWVLDQFNLNLKAGEPTAIVGPSGKGKTTLIRLLLSLIKPEKGEILLTDRDGIHVLTAAHRINFAYIPQGNSLLSGTIRENLLLHVKDGGHIAIEKALRIACAEFVLELPDGVDTVVGESGMGLSEGQAQRIAIARALMHDGDIWLFDEVTSALDRKTADLLIQRLLEYGHDKLCLFVTHDLSLVDKCKHHIYLD
>NZ_CP009278.1|WP_038701737.1|5152563_5152833_+|PqqD-family-protein
MKLRADLVLRTIGSDHMIVDPGQEMVDLSTVYTLNDTAAWLWEQLQGIDFTIASIVELLCQQYEVTEQQALADAETLIKDFEKQGLLEK
>NZ_CP009278.1|WP_051960213.1|5152046_5152499_+|hypothetical-protein
MKKTESMTISNALYFEEVQRLLEEGKEVCIRVKGNSMLPFIKSGDRVLLVAYQGEPLPKGANILAKHEGNYIFHRYVGKKGDKYLLAGDGNLVLHEYIAEKDILALATRHYPTSGDETIAIDKPLYRFRGMAWYYMRIIRKIITVLKRRF
>NZ_CP009278.1|WP_038701736.1|5151127_5152033_+|DUF5106-domain-containing-protein
MKCTTFKIWFFLGAITLLSVSCNQHSKSEKQNADNDIKKEHYTAADSAVLTYWDKFDMADTVKIKDPNMGEQKLADFIAALNTVSDTVADHAIANMLDGTKASKVGFDHFIKLYEHYLYDGNSPMRNDVRYESVLRYLIQTDRLSDLEKEAYRPIYKLVQRNKLGKKAEEFDFERSDGQVQKLSDVKAKYTLLLFYDTECTHCKETLDLLKDTPQLVQLFEQKQVQVLAIEPWGDRPKWKGYQSHLADNWINGFDRESTIQHERLYDLKASPTLYLLDENKNVLLKDTQLQELIQYLIRLI
>NZ_CP009278.1|WP_038703214.1|5150272_5150695_-|adenylyltransferase/cytidyltransferase-family-protein
MRVGITFSAFDLLHAGHIKMLEDARRQCDYLICGLQTDPTLDRPEKNKPTQTVVERYIQLKGCKYVDQIVPYATEQDLEDVLRSFKVDVRIVGDEYRERDFTGRQYCEESGIALYFNSRDHRFSSSGLRRIVAEHEVEKG
>NZ_CP009278.1|WP_038701735.1|5149747_5150173_-|adenylyltransferase/cytidyltransferase-family-protein
MKIGITFGVFDLLHAGHIMMLEEARRNCDHLIVGLNTDPSEVSPDKAKPTQTVVERYIQLEGCRYVDEIIPYETEQDLTDIIKALPIQVRIIGEEYRDMEFTGKKYCIEEGIEIYYNKRSHRFSSEGLRKVVAAKEAEKIG
>NZ_CP009278.1|WP_038701734.1|5148523_5149522_-|NTP-transferase-domain-containing-protein
MSDIIHVILSGGVGSRLWPLSRKSYPKQYLSLFKEGSLFEMTVKRNQGFCNQVIVVGNKDNNQLSRQVMESSGVDYIDIVESTPRNTAAAIAFAAFAANPDDILVVTPSDHVIVGEDAYNQAIEEAIVKANQGYIVTFGIQATKPETGYGYIEFEGDQVVSFREKPNKETAEDFIERGNFLWNSGMFCFRADTLLHELQQFEPRVYATALAAWQHKKDGILDEALSKEIPSISIDYAVMERSKKIRVVATDFTWSDLGSFESMYDYLKETGHPTDENGNMVIGTDIFSAFVGLKNTILVYTNDAFLVLQKESSQDVKKIYNTLERHQSKLID
>NZ_CP009278.1|WP_038701733.1|5147569_5148046_-|hypothetical-protein
MLILVLIIFLFIGCYYFWAARQRNQRFANHGQMSVSYLFQERPGQYSGDRSIKSGVLVIHSRSHDEKLKHATIKHVHLQHPDLRIHLEQSLALPFQHDEVSKPEVSVRYKVIKNDIDTVDLTGVNTTIAGKLHFVSGASKTFKVTVPISGLYQEQGQN
>NZ_CP009278.1|WP_038694773.1|5157323_5158499_+|IS4-family-transposase
MVNLNVFSQILSLIDRELFKVLVAKHKSDKHCKGINSWTHLASMLFCHFSSADSVRDISNGLRSTTGNLNHLGVGRAPSKSNISYINKHRTHELFKDLYFSLLDKLWQKDTHLRKDLTQLKRKVYLMDASIIPLCLSVFDWAKFRSTKGAVKLHTVLDYDGCLPVFMQITDGKVHESQRAGSYSFSKGSVVVVDRGYVDYNWLGDLDSRGCYFVTRSKTNMKYNVIKSYQSEALLEKGIIKDEIIELSGPSADRYNSKPLRLIHFWDSSTDNQYHFLTNNIQWKASLVANIYKQRWQIEIFFKHLKQRLKISSFVGTSENAVMIQIWTSLIGILLLKYLQKKAKYDWNLSNLVGFIRMNIFVKINIWQWIDDPFIRPPVKGKNGQLQIFSD
>NZ_CP009278.1|WP_144243387.1|5158912_5159449_-|hypothetical-protein
MFYIYLLLGIVFVFSILYYRKNVRLSHQFKERATLRAQYRFQHMENVEHESGKSKNGALILTVERLNFDTRNIVIKEVTLDHSCYHISLDQLIMISFPADSVTAYEASVRFRVRGSLSKAGVLSDRQALISGYITSDLSGRIPFRLRVPVEKFEAEDAPVDAQVSASKGDLGRQPNFG
>NZ_CP009278.1|WP_038701742.1|5160005_5160533_-|3'-5'-exonuclease
MKSDLTFTAIDFETATGHQNSACAVGIVTVESGIITNEFYSLIQPPRNEYMWQTTRVHGIKPRDTAHSPTFKELFPTIQSLLANKLMIAHNELFDRNVLRKTMLHYGLAYDELQLAEMWECTYKIYRNKGFKPARLNACCEVLGIDLNHHEALSDARACAELYLRHPFVETLIEG
>NZ_CP009278.1|WP_038701743.1|5160684_5161992_-|replication-associated-recombination-protein-A
MATRIPLAERMRPKKLEDYVGQQHIVGHDAVLYHAIQQKNIPSMLLWGPPGVGKTSLALLMAKELGRPFFSLSAIQAGVKDIREVIEKAEKLMHINQEQPMMNFKQEQPILFIDEIHRFSKSQQDSLLGAVERGLVTLIGATTENPSFEVISALLSRCQVYVLEHLSSVDLIGLVERSLHEDEFLKEQSIEIEEYEAILRLSGGDARKLLNVLELVSNAAVLHHEPITNAFVLKQVQQNMAIYDKTGEQHYDIISAFIKSIRGSDPNAAIYWLARMIEGGEDPSFIARRLLISASEDIGNANPNALLLANNCFQAVNVIGWPESRIILAQTVTYLASSPKSNASYEAINKAIGVVKQTGDLSVPLHLRNAPTKLMKQLNYGAEYKYSHAYPGNFVTQEFLPDAISGTTFYDPGKNPQEDKLRQSLRDKWKEKYRY
>NZ_CP009278.1|WP_038701744.1|5162213_5163791_+|DUF3843-family-protein
MKKNRIYIQDWLGQHPYQGRSDADSYYLQVANEINNALSTLWFDEEETDALIRPEIIKTLSIYLTCYLEDVVSGTKLFEAFRLEHQALYSKMLPYFDDQELTDYYSEDINPQDVLVLTWLFFSERNPHLFLDKDGRLIALVTDLAYAVLEEHYEVAPENTLLQQEYTLPADANYLQVRNFSEKVIATNYITGGYYYNSLMQHMDIADLGRYQHDPAYLNQMTFRVRDNHFIFFRLHLLALKSCEFVSAMLGTAHPQYENTRAIGNRIDSFFEYEKVTHDQLQLKHLSTGELFLVNLNSIQNFKEPAAGQLFYMEIVPWKDAWNLSGMMSAIEADQIDLTTDPETTQTYLVEALRGKRTQIEKTEQQIAEVKALFSKKHNDLLAFMSEVDMNDYIHELTNTYREQKGLALVDKQDSSDASKDKSVTAFYNPKFGLEFFGGIAELFPLEQNPFFVKNENEPINYAQNLLQLLVQKFFSVGLVEHYYALYEKEINEQFFYPLDRNTLDFLLRFYKSETYHSLPLLMIK
>NZ_CP009278.1|WP_038701745.1|5163952_5165377_-|arylsulfatase
MKKTALFALFLALSGATLAQKKDKRPNIILIMADDLGYGDLGAYGQKIIETKHLDALAKEGIRFDNFYAGTSVCAPSRSALMTGQHTGHTPIRGNKEIEPEGQQPLADSVQTMAMLLQQAGYATGAFGKWGLGMVDTYGSPNQKGFEEFYGYNCQRQSHRYYPTHLWHNKERIHLEGNGLLAKGQYAPALIQEKTLAFIEDNKDQPFFLYVPTVLPHAELSGPDDEFYEQYANKFEEKAHKGNDYGPNATIPGYASVAKPRATYASMVSRMDAQVGQIVAKLKALDLLENTLIIFTSDNGAHREGGADPDFFNSSGGLRGYKRDLYEGGVKTPFIVYWKGKIAPGTTSDYLGAFWDVMPTLAEIAQADKPRNTDGLSFVPTLLGNAKKQKKHDHLYWEFHEDGGRQAVRKGDWKLILQKVKSGNPIPELFNLKQDPKEERNLAASNPKKAEELRKLIAQSHVENADFPLLKTEK
>NZ_CP009278.1|WP_144243388.1|5165646_5166750_+|hypothetical-protein
MKFWEISFLSTAFLLILGLTAFSQELSKDYTGSITQYNSNFSGIGPKVYFLPPPKSKTEQLIDLYESNDRKDFAKKIIAELRYNMLLQELKNLKDNGPGQHLKIPTDTSAWQELIARAKNQFDHVYTYSLLNAAGLAAVEQHLTDQGTAYLQEAIAIAAKEKDQQDLPTLLHNLAAVQLYTKAYEKAAHTAQEILTRLNKSKNYSEQADAWMQFAMANSGMKNYNVAEPNIIRKAIPLYNKAKNFEGKIIAWQQLAQVYYEQNKYTQAQWFLLQAQQLAKNKNYTADLAEIEYVLASSKLLDNNINIAKKEFLTALILARNEKNKHLELAVLDKLGEVYITLKEYEEAENTYQDFSNLKAELKKDTD
>NZ_CP009278.1|WP_038701747.1|5166809_5167547_-|dienelactone-hydrolase-family-protein
MKNLIMTILCFCVTESSFAQLKTINYKDGDQKLTGLLNSDAGAGAPGVLILPAWMGIDDEATQAAAQLSKSGYMTFVADIYGEGNKPSNAAEAGKQAGKYKNDFQAYQRRIRLALEELVRAGASPGRLAVMGYCFGGTGALEAARGDLEVQGVISIHGNLGKGSRPDGPLNTKILVLHGAADPHVSNEEIANFRTEVESAHADWQMIYYADAKHAFTNPESPDFQPLAAQRSWKHLQVFLEEILK
>NZ_CP009278.1|WP_144243389.1|5167771_5169892_+|carboxy-terminal-processing-peptidase
MFKKLIFTLFVISIVSCGSKPRVNLSEVEGGLKPSAQHEVIAKEVAGLLESTSYKKVQLNDSISNIVFDNLIKSLDQGKNYLLQSDIDEFQQYRNTLGQDFRKGDLSAPFHIFNVYAKRYLERIQYALTQVDVKQDFTIDESYLPSREKLGWFKSVTEADTQWKHRVKYDLLNLEMTTVNKTDSTANKQKETLRKRYTNLISQGKKINANDAFQLMITALTDAVDPHTSYFNPSFAQAFNEGMANTFEGIGARLMIDNEMVTIMEIIPGGPIFKDKSLAIDDKIIGVAQGKDGEFEDIIGWRLDAAVAKIKGPAGTIVRLKILPAGQQISAHPKIVSLTREKIVLAEESAKKEILNVKGADGKNYRVGVINIPKFYMDFEAYRKRDPNYKSTTRDVRLLLDTLKQEKVDAVMIDLRFNGGGSLPEAIDLTGLFIDKGPVVQVRDIRNAVDVEEDKNAGVSWDGPLGVMINRFSASASEIFAGAIQDYGRGVILGSQSYGKGTVQSAVDMARVISPTSKLLLKAQNEKDPDTPNGAPEYGQINITLGKFYRVNGSSTQHKGVSPDVAFPTQYSAEKFGESSEPSALPWDQIKSSNYTKVADLTAINKTLEQEHEERMKTSTEYKFLLEDIATFEKRDEETKIPLQLDKFKKERDDFQKKNRDRVNALLKQRGLPLWEEGKPQPKMEFDFVQDESAKVMTDLIIQEKK
>NZ_CP009278.1|WP_038703216.1|5169971_5171681_-|glycoside-hydrolase-family-3
MMIKKFALAVVTLASTISFSQAQDKKDFVQYINTPHTWVDSVFNTLTPKERIAQLFLVRAHTNLGQRYIDSVAQVVHDEQLGGLVVFQGGPERHVAMFNNYQQLSKVPLLITFDGEWGLGMRLPDSTLSYPYQMTLGAIQNDQLIHQMGQEVAKDFHRIGMHFNFAPVVDINNNPKNPVIGFRSFGDNKENVARKAKAYMDGMMDGGIISSLKHFPGHGDTDVDSHHDLPQLTFSKERLEDLEMFPFKALIKDGAPAIMVAHMNIPSLDPTPNIPSSISKPIVTGILRDQLGFRGLIVTDAMDMNGVKKFFPNGEADVMAIIAGHDLLEVSENSKRAIDLVLKAIQEGRINQADVDARVKKVLASKLWLGLDQYKAVNPQNLYAELNRPSAKQLIDQLSEASVTVLKSTAKIKAFKPSEKTAILNIGLQAPSTFQNIMATALSNETQYYIAADATEAELAPIIKEAKKNKQIILAIHDTRSRPRPEVAASDAVKSLVKKLAKKSIVTFFTNPYAIDGFAGVQKSKTIIVAYQNDDFMQRAVAQTILGQNIPSGKLPVTINKYFRYGDGK

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

20732 : 68690

Streptococcus_phage(25.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_038694773.1\|20732_21908_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_038694775.1\|22414_23584_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_158500250.1\|24102_24258_-	hypothetical protein	NA	NA	NA	NA
WP_158500251.1\|24762_24924_+	hypothetical protein	NA	NA	NA	NA
WP_144243229.1\|25292_26663_-	hypothetical protein	NA	NA	NA	NA
WP_038694781.1\|26773_27691_-	hypothetical protein	NA	NA	NA	NA
WP_038694783.1\|27729_29292_-	hypothetical protein	NA	NA	NA	NA
WP_038694785.1\|29327_32759_-	TonB-dependent receptor	NA	NA	NA	NA
WP_038694787.1\|32877_33888_-	DUF4974 domain-containing protein	NA	NA	NA	NA
WP_038694789.1\|34216_34804_-	RNA polymerase sigma-70 factor	NA	NA	NA	NA
WP_051959697.1\|34944_36207_+\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_081918269.1\|36358_36796_+	ATP-binding protein	NA	NA	NA	NA
WP_144243230.1\|36792_36990_-	hypothetical protein	NA	NA	NA	NA
WP_038694793.1\|37198_37579_+	Fur family transcriptional regulator	NA	NA	NA	NA
WP_038694795.1\|37854_38700_+	tetracycline regulation of excision, RteC	NA	NA	NA	NA
WP_038694796.1\|38951_39305_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_038694798.1\|39316_39622_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_038694800.1\|39710_41186_+	DUF3945 domain-containing protein	NA	NA	NA	NA
WP_038694802.1\|41205_43293_+	type IA DNA topoisomerase	A0A1X9I6W8	Streptococcus_phage	8.6e-36	28.5
WP_038694804.1\|43292_44207_+	ORF6N domain-containing protein	NA	NA	NA	NA
WP_038701898.1\|44245_45478_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.2e-59	58.3
WP_038694806.1\|45549_46374_-	tetracycline regulation of excision, RteC	NA	NA	NA	NA
WP_081918270.1\|46765_49288_-	serine hydrolase	A0A2H4JAN9	uncultured_Caudovirales_phage	4.2e-13	28.8
WP_081918271.1\|49868_50951_-	DUF2931 family protein	NA	NA	NA	NA
WP_038694808.1\|51053_52067_-	hypothetical protein	NA	NA	NA	NA
WP_038694810.1\|52075_52654_-	hypothetical protein	NA	NA	NA	NA
WP_038694773.1\|52861_54037_+\|transposase	IS4 family transposase	NA	NA	NA	NA
WP_038694812.1\|54310_56311_+	TraM recognition domain-containing protein	NA	NA	NA	NA
WP_038694813.1\|56796_57690_+	hypothetical protein	NA	NA	NA	NA
WP_038694815.1\|57893_58187_+	hypothetical protein	NA	NA	NA	NA
WP_038694817.1\|58292_59018_+	response regulator transcription factor	NA	NA	NA	NA
WP_158500252.1\|59127_60921_+	hypothetical protein	Q9EYF3	Enterobacteria_phage	3.1e-10	28.7
WP_038694821.1\|61161_61728_+	hypothetical protein	NA	NA	NA	NA
WP_144243231.1\|61735_62020_+	hypothetical protein	NA	NA	NA	NA
WP_038694823.1\|62113_63352_+	serine hydrolase	NA	NA	NA	NA
WP_038694825.1\|63520_64282_+	hypothetical protein	NA	NA	NA	NA
WP_038694827.1\|64295_64895_+	hypothetical protein	NA	NA	NA	NA
WP_144243232.1\|64905_65136_+	hypothetical protein	NA	NA	NA	NA
WP_038694831.1\|65132_66290_+	hypothetical protein	NA	NA	NA	NA
WP_144243233.1\|66282_66672_+	carboxypeptidase regulatory-like domain-containing protein	NA	NA	NA	NA
WP_144243234.1\|66742_67243_+	hypothetical protein	NA	NA	NA	NA
WP_038694773.1\|67514_68690_-\|transposase	IS4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

4971822 : 4995888

Bacillus_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_038701479.1\|4971822_4972137_+\|transposase	transposase	NA	NA	NA	NA
WP_144243378.1\|4972121_4972646_+\|transposase	IS3 family transposase	A0A1P8CWQ3	Bacillus_phage	1.5e-21	40.3
WP_051960177.1\|4972672_4973044_+\|transposase	transposase	NA	NA	NA	NA
WP_081918452.1\|4973106_4973280_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_158500330.1\|4974034_4974244_+	hypothetical protein	NA	NA	NA	NA
WP_081918454.1\|4974632_4975049_-	Fur family transcriptional regulator	NA	NA	NA	NA
WP_051960181.1\|4975460_4976705_+	GTP-binding protein	NA	NA	NA	NA
WP_038701481.1\|4976768_4979129_+	TonB-dependent receptor	NA	NA	NA	NA
WP_051960184.1\|4979154_4981371_+	TonB-dependent siderophore receptor	NA	NA	NA	NA
WP_038701483.1\|4981479_4982181_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.1e-27	31.9
WP_038701485.1\|4982189_4983602_+	DUF3526 domain-containing protein	NA	NA	NA	NA
WP_038701487.1\|4983598_4984912_+	DUF3526 domain-containing protein	NA	NA	NA	NA
WP_038701489.1\|4985476_4986055_+	hypothetical protein	NA	NA	NA	NA
WP_038701493.1\|4987067_4987952_-	hypothetical protein	NA	NA	NA	NA
WP_038701495.1\|4987962_4990032_-	TonB-dependent receptor	NA	NA	NA	NA
WP_038701497.1\|4990049_4990664_-	hypothetical protein	NA	NA	NA	NA
WP_038701501.1\|4992373_4992688_-\|transposase	transposase	NA	NA	NA	NA
WP_038701503.1\|4992719_4992917_-	DUF4172 domain-containing protein	NA	NA	NA	NA
WP_038701505.1\|4993133_4993355_+	hypothetical protein	NA	NA	NA	NA
WP_038701508.1\|4993734_4994313_+	outer membrane beta-barrel protein	NA	NA	NA	NA
WP_038694773.1\|4994712_4995888_+\|transposase	IS4 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

5143583 : 5150695

Escherichia_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_038701725.1\|5143583_5144444_-	glucose-1-phosphate thymidylyltransferase RfbA	H9NC64	Sphingomonas_phage	1.7e-102	65.0
WP_038701727.1\|5144694_5145564_-	dTDP-4-dehydrorhamnose reductase	NA	NA	NA	NA
WP_038701729.1\|5145550_5146111_-	dTDP-4-dehydrorhamnose 3,5-epimerase	A0A1D7XFA9	Escherichia_phage	1.3e-34	43.7
WP_038701731.1\|5146355_5147417_-	dTDP-glucose 4,6-dehydratase	A0A291LAD7	Escherichia_phage	8.9e-90	50.9
WP_038701733.1\|5147569_5148046_-	hypothetical protein	NA	NA	NA	NA
WP_038701734.1\|5148523_5149522_-	NTP transferase domain-containing protein	A0A1V0SH58	Hokovirus	7.0e-28	27.9
WP_038701735.1\|5149747_5150173_-	adenylyltransferase/cytidyltransferase family protein	A0A218MN49	uncultured_virus	4.7e-34	50.0
WP_038703214.1\|5150272_5150695_-	adenylyltransferase/cytidyltransferase family protein	A0A218MN49	uncultured_virus	7.0e-38	52.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP009278

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection