CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP008758	Burkholderia pseudomallei strain 1106a chromosome 1, complete sequence	1 crisprs	cas3,DEDDh,csa3,DinG	0	0	4	0
NZ_CP008759	Burkholderia pseudomallei strain 1106a chromosome 2, complete sequence	1 crisprs	cas3,csa3,DinG	0	0	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP008758_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP008758_1

3791944-3792023

Orphan

Consensus_repeat	Method
ACGGAATGGGCCCCGGCATGATG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP008758_1

>merge|NZ_CP008758|1|3791944-3792023|CRISPRCasFinder
ACGGAATGGGCCCCGGCATGATGGGCGGCGGCTACGGGCGCGGAATGATGGGCGGCTACGGAATGGGGCCCGGCATGATG

>NZ_CP008758|1|1|3791944-3792023|CRISPRCasFinder
ACGGAATGGGCCCCGGCATGATG	GGCGGCGGCTACGGGCGCGGAATGATGGGCGGCT
ACGGAATGGGGCCCGGCATGATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP008758.1\|WP_011854010.1\|3789502_3790597_-\|polyamine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270377
NZ_CP008758.1\|WP_004524603.1\|3801646_3802207_-\|spermidine-N1-acetyltransferase	unknown	unknown	gnl\|CDD\|237916
NZ_CP008758.1\|WP_004190110.1\|3797930_3799025_-\|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada	unknown	unknown	gnl\|CDD\|185333
NZ_CP008758.1\|WP_004535409.1\|3795220_3796834_-\|glutamate--cysteine-ligase	unknown	unknown	gnl\|CDD\|235001
NZ_CP008758.1\|WP_004535730.1\|3796992_3797934_-\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NZ_CP008758.1\|WP_004531075.1\|3793758_3795207_+\|RNA-polymerase-sigma-factor-RpoD/SigA	unknown	unknown	gnl\|CDD\|274108
NZ_CP008758.1\|WP_004536330.1\|3786874_3787339_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008758.1\|WP_004524602.1\|3802368_3802539_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008758.1\|WP_004535786.1\|3785384_3786476_-\|phage-portal-protein	unknown	unknown	gnl\|CDD\|222860
NZ_CP008758.1\|WP_009961942.1\|3783358_3783532_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008758.1\|WP_004536377.1\|3790739_3791708_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
NZ_CP008758.1\|WP_004536432.1\|3800813_3801161_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008758.1\|WP_004535322.1\|3787475_3788351_-\|N-carbamoylputrescine-amidase	unknown	unknown	gnl\|CDD\|274553
NZ_CP008758.1\|WP_004535781.1\|3783535_3784360_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371744
NZ_CP008758.1\|WP_004202809.1\|3784984_3785341_+\|putative-addiction-module-antidote-protein	unknown	unknown	gnl\|CDD\|188241
NZ_CP008758.1\|WP_004536006.1\|3788361_3789474_-\|histone-deacetylase	unknown	unknown	gnl\|CDD\|212521
NZ_CP008758.1\|WP_004200732.1\|3782529_3782934_-\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP008758.1\|WP_004197761.1\|3799426_3799843_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319916
NZ_CP008758.1\|WP_004197759.1\|3800039_3800594_-\|YaeQ-family-protein	unknown	unknown	gnl\|CDD\|377782
NZ_CP008758.1\|WP_004525837.1\|3792947_3793496_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP008758.1\|WP_004524603.1\|3801646_3802207_-\|spermidine-N1-acetyltransferase	gnl\|CDD\|237916	PRK15130, PRK15130, spermidine N1-acetyltransferase; Provisional.	7.47948e-86
NZ_CP008758.1\|WP_004190110.1\|3797930_3799025_-\|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada	gnl\|CDD\|185333	PRK15435, PRK15435, bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada.	2.28522e-121
NZ_CP008758.1\|WP_004535409.1\|3795220_3796834_-\|glutamate--cysteine-ligase	gnl\|CDD\|235001	PRK02107, PRK02107, glutamate--cysteine ligase; Provisional.	0
NZ_CP008758.1\|WP_004535730.1\|3796992_3797934_-\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	9.65357e-54
NZ_CP008758.1\|WP_004200732.1\|3782529_3782934_-\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	4.3525e-28
NZ_CP008758.1\|WP_004197761.1\|3799426_3799843_+\|VOC-family-protein	gnl\|CDD\|319916	cd07253, GLOD5, Human glyoxalase domain-containing protein 5 and similar proteins. Uncharacterized subfamily of VOC family contains human glyoxalase domain-containing protein 5 and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.46868e-30
NZ_CP008758.1\|WP_004535786.1\|3785384_3786476_-\|phage-portal-protein	gnl\|CDD\|222860	PHA02536, Q, portal vertex protein; Provisional.	0
NZ_CP008758.1\|WP_004536377.1\|3790739_3791708_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.03052e-69
NZ_CP008758.1\|WP_004535322.1\|3787475_3788351_-\|N-carbamoylputrescine-amidase	gnl\|CDD\|274553	TIGR03381, putative_carbon-nitrogen_hydrolase, N-carbamoylputrescine amidase. Members of this family are N-carbamoylputrescine amidase (3.5.1.53). Bacterial genes are designated AguB. The AguAB pathway replaces SpeB for conversion of agmatine to putrescine in two steps rather than one. [Central intermediary metabolism, Polyamine biosynthesis].	0
NZ_CP008758.1\|WP_004535781.1\|3783535_3784360_+\|hypothetical-protein	gnl\|CDD\|371744	pfam11820, DUF3339, Protein of unknown function (DUF3339). This family of proteins are functionally uncharacterized. This family is found in eukaryotes. Proteins in this family are about 70 amino acids in length.	0.00799298
NZ_CP008758.1\|WP_004202809.1\|3784984_3785341_+\|putative-addiction-module-antidote-protein	gnl\|CDD\|188241	TIGR02684, conserved_hypothetical_protein, probable addiction module antidote protein. Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the downstream member of a gene pair. It is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, are located often with prophage regions, but also both in integrated plasmid regions and in housekeeping gene regions. Analysis suggests that the gene pair may serve as an addiction module. [Mobile and extrachromosomal element functions, Other].	6.66352e-41
NZ_CP008758.1\|WP_011854010.1\|3789502_3790597_-\|polyamine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270377	cd13659, PBP2_PotF, The periplasmic substrate-binding component of an ABC putrescine transport system and related proteins; contains the type 2 periplasmic-binding fold. This group represents the periplasmic substrate-binding domain that serves as the primary polyamine receptor of ABC-type putrescine-preferential transporter from gram-negative bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.39312e-149
NZ_CP008758.1\|WP_004531075.1\|3793758_3795207_+\|RNA-polymerase-sigma-factor-RpoD/SigA	gnl\|CDD\|274108	TIGR02393, RNA_polymerase_sigma_factor_RpoD, RNA polymerase sigma factor RpoD, C-terminal domain. This model represents the well-conserved C-terminal region of the major, essential sigma factor of most bacteria. Members of this clade show considerable variability in domain architecture and molecular weight, as well as in nomenclature: RpoD in E. coli and other Proteobacteria, SigA in Bacillus subtilis and many other Gram-positive bacteria, HrdB in Streptomyces, MysA in Mycobacterium smegmatis, etc. [Transcription, Transcription factors].	2.83254e-88
NZ_CP008758.1\|WP_004197759.1\|3800039_3800594_-\|YaeQ-family-protein	gnl\|CDD\|377782	pfam07152, YaeQ, YaeQ protein. This family consists of several hypothetical bacterial proteins of around 180 residues in length which are often known as YaeQ. YaeQ is homologous to RfaH, a specialized transcription elongation protein. YaeQ is known to compensate for loss of RfaH function.	3.23549e-104
NZ_CP008758.1\|WP_004536006.1\|3788361_3789474_-\|histone-deacetylase	gnl\|CDD\|212521	cd09996, HDAC_classII_1, Histone deacetylases and histone-like deacetylases, classII. This subfamily includes bacterial as well as eukaryotic Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. Included in this family is a bacterial HDAC-like amidohydrolase (Bordetella/Alcaligenes species FB18817, denoted as FB188 HDAH) shown to be most similar in sequence and function to class II HDAC6 domain 3 or b (HDAC6b). FB188 HDAH is able to remove the acetyl moiety from acetylated histones, and can be inhibited by common HDAC inhibitors such as SAHA (suberoylanilide hydroxamic acid) as well as class II-specific but not class I specific inhibitors.	5.49698e-171

>NZ_CP008758.1|WP_004536377.1|3790739_3791708_+|LysR-family-transcriptional-regulator
MRRIDLLSALETFVCAVEEGSLSQAARRLAKTPSAVTKAIAGLEATLGVQLLERTTRRLALTESGRLYLATATDVLRRLADGARQLSERDDEPRGLLRVTAAHSFGHAILAPLCAPFAQAFPRVRIELSLSDHYVDIVGEGFDLALRMGNYDLPSQIVKPIGSNRGLPCASPGYLARRGRPTAPADLAQHDCVIYRHPTLANTWTFERGGVRARLEPKGPLVTDDYGLALAAALDGAGVLPCPQWSVVDALEAGRLVPLLIDWRFESASFGEDRICAAYPSSRRGSTKIRRLVERVQARLADSEARVAHVLGDALCADLARR
>NZ_CP008758.1|WP_011854010.1|3789502_3790597_-|polyamine-ABC-transporter-substrate-binding-protein
MKRIAWLAAVLASLACAAARAADGNVLNIYNWAEYFAPDTIAGFEKETGIKVRLDVYDSNEALQTKLTTGNSGYDLVFPSNDFLARQIQAGLYRKLDKSRLPNLTNLDPAIVARAAEVDPGNQYSVPYMQGTFGLGLNVAKVKQALGGPLPANTLELIFNPAYAAKLERCGIAFNDAGSEVFPLALRYIGRDPNTTDPRDYEAALDMMKKIRPTIRQFIATPVMNDLATGDVCVVTGYSGAVLVAARRAAEAKNGQQIVYSLPSAGAPFWFDSMAIPKGAAHADHALRFIDYILRPDVVAKISNKVMYPNPNRVATPLVDRRLTANPAIYPDAATMRTLWVKRPMPPQAIRMQTRYWTRFKTGY
>NZ_CP008758.1|WP_004536006.1|3788361_3789474_-|histone-deacetylase
MIPTGLLFDPAFLSHRQGDLVYVVPHGTLNLGEHFDSSLRLAYTKQLLDAVGMTERLTRVAFARATDEQLLRVHRPEYLRQLAEACAVAGEQVVRLGDDAAGSASTEDVARLAAGAACAAVDAVMTGPLRQAYALIRPSGHHAGADFAMGYCYYNNVAIAARHAQAAHGVERVAIVDWDVHHGNGTQQTFYDDPSVLFVSLHEAANFPVDGGEARETGGGAGAGYNANVPLPSGTGDAGYRHAFDELVLPLVEAFAPQLILVSAGQDANAFDPLGRMRVQRDGFRHMARALRQAAGGACGGRIVMLQEGGYSLPYLPIATLGVLEGLVGWNAPFDDPHQFVQYPLGEGERAAVKAARAALAPYWPTLHRS
>NZ_CP008758.1|WP_004535322.1|3787475_3788351_-|N-carbamoylputrescine-amidase
MRKTTVAVTQMACDWNVDANLSRAERLVRDAAARGAQIVLLQELFETPYFCIDQHPAHLALAQPYEGHPWLMRFASLARELGVVLPVSFFERAGQTQFNSVAIFDADGRALGIYRKTHIPDGPGYTEKYYFTPGDTGFRVWDTAYGRIGVGICWDQWFPECARAMALAGAELLLYPSAIGSEPHDASIDSRAHWRNAQRGHAAANLMPVAASNRVGVERGASGEIVFYGSSFIAGADGEMIVECDRHDEAIATAEFDLDALAYRRRGWGVFRDRRPECYRALSEGAADRVR
>NZ_CP008758.1|WP_004536330.1|3786874_3787339_+|hypothetical-protein
MEFRPIKESDLGSTYDIRFPVTENRILPHQIHLLERDRVLEQLRSGFGVLAIEGDAAVGYCTAAGLGGPGKRSWRTAPKHCHAGPRRLRERAALAAAAPMAARSRPRGCVTCKAPSAERRSPSETSCASARTGRRAPFGRFSAFAAHRQAGRRH
>NZ_CP008758.1|WP_004535786.1|3785384_3786476_-|phage-portal-protein
MSSWRRRASTTAPSACSNVTSSAATTLRNRPRQIRAPARAEVFTFDDPTPVMNRAEILDYVECWSNGEWFEPPVSFAGLAKSFRASTHHSSALFFKANVLASTFRPHRWLSRHAFERWALDFLTFGNGYLERRRNMVGGTLRLEPALAKYVRRKADFNGFVYVNGWQERHEFEPDSVFQLVRPDINQEVYGLPEYLSSLHSAWLNESSTLFRRKYYENGSHAGFILYMTDAAQKQDDVDNMRDALKNAKGPGNFRNVFMYAPGGKKDGIQLIPVSEVAAKDEFFNIKNVTRDDLLAAHRVPPQLLGIVPSNSGGFGTPDTAARVFGRNEIRPLQARFAELNDWLGDEVVTFDDYEIPPVPVAA
>NZ_CP008758.1|WP_004202809.1|3784984_3785341_+|putative-addiction-module-antidote-protein
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIMKVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA
>NZ_CP008758.1|WP_004535781.1|3783535_3784360_+|hypothetical-protein
MNVAFPAVFLFLLLSPGILFHRHYQPREVRAADMSPFGTTVVTVAIASLIFNAATMAVAIHWFRYEFHLGQMVRLLVDGRLATNDPDLASLFGRLDRYPTEPLLFFLAANLLAGATAALWRVLVLWLRLDHPSFPYYTHLRPPAPWHYLFSGVDVVDFTPDAVVVAALVPLKESTYIFTGLLRDYELTDKGELERIVISQAARRRLEDDRKHDNSTSRLSPENFERFYWIEGDTLVLRASEFTTLNIKFLVLEPLNEASQEKNLHASRHRNQSA
>NZ_CP008758.1|WP_009961942.1|3783358_3783532_+|hypothetical-protein
MKVVLTDKVRTLQKDVQGARELRDFIASAKLNETKEIKVTAEQGKQLKFRAKLVPQG
>NZ_CP008758.1|WP_004200732.1|3782529_3782934_-|PaaI-family-thioesterase
MDENTVRDLLDRLLAPWVRSLSLTPVSISEESVTLRLPFSGEFRHSGGVICGQVFMAAADTAMVVAISAALGEFRPMTTVALNTHFMRPVRKGDVLVTARVLRMGRNLVFGEIELFDEDGKMAVHATSTYALVS
>NZ_CP008758.1|WP_004525837.1|3792947_3793496_+|hypothetical-protein
MEEAYARRALLLHLGSVLQILSRLEGAPDNQSIEALLAANGMLADVPLVEYVVQDMTVREFSARALRAFCLWPQLLLEDPLDCAALALPVRKHLFAGNDAGWKAYAATLREVSPGFDTARSYAAEPHEAEFDLADERDAETGDGPVERDDEADDDGRLRERAAASVESATPAGAPVRRESYE
>NZ_CP008758.1|WP_004531075.1|3793758_3795207_+|RNA-polymerase-sigma-factor-RpoD/SigA
MKVSARELRYEQGIDRLLELAGARDDTEYADVADEFASAPSSAFAHDLGEPDSLDHQASDESAGAGSFGDKPTRPAHGDTDVDTDWRDDDAPPSGSNDAAPVDTTASTDPLALFVRRMHAVPLLTHAQEIALAAEIEAGREQVLQALAEALDRLDLASLPADPALGRARAALQRARARGDEGARAFARARTAAYAALAAHGWPSAEVDAVRRAMRRLPTSPEKSDAGAQRAFADGEARISAATARMAEANLRLVLSIARKYASRGLDLADLLQEGNLGLLRAIEKFEHRRGFKFSTYATWWIRQAISRAIADRARTIRVPVHVGDEARRVRKAADRIERRSGVSASLAELSEATGLPAERLRAVLTLPREPRSLNAPLGDDDQAEFGDIVEDTSTPSLFDALAHGQMCDVVTSLLKTMSAQEADILRRRFGIGGDEPWSYEQIAARAGVSREQVRRIEKRALQTLRVTAEACNAHDFLDVQP
>NZ_CP008758.1|WP_004535409.1|3795220_3796834_-|glutamate--cysteine-ligase
MPNNMTSRQTDLLQQRLAVLSTSPTREQLPDGLRGIEKESLRVTRDGMIAFTPHPRALGSALTHPSLTTDYSEALVELITPAERDAATTLERLDELHRYVYASLGDEMLWTDSMPGLLPADDEIPIADYGTSNIGRLKTVYRRGLAYRYGRTMQCIAGIHYNYSLSEEVWRRLHAEEGSTAGIVDYQSERYLALIRNFRRTSWLLMYLFGASPALDAGFLRGRAHKLDTFDAATLYRPHATSLRMSDLGYSNTTAQAALQADYNTLSGYLDALSKAVSEPYPPYEAIGTHRDGEWIQINTNVLQIENEFYSTIRPKRVTYSGERPLHALASRGVQYIEVRCLDIDPFEPTGIALDTARFLDAYLLVCALDESAPLTCDAYRESNANFGRVTMEGRKPGLELTRDGAAVPMRAWADEIFAQIEAAGRVLDDIRGDDTHARAIAAQRAKLDDPELTSSARVLRAMRENGQSFLEFARAQSAAHAAYFHGRPLDEAATRDARALAERSLAEQAELEGKNAGSFDAFVAAYRAYTLNRFSV
>NZ_CP008758.1|WP_004535730.1|3796992_3797934_-|DNA-3-methyladenine-glycosylase-2-family-protein
MSAAVEPAAVRPDSVVLELPFKSPYDWPRVLRFFAGRAIPGVEAVGDGAYRRTVDHHGAIGTLTVRKHPRKRCLVALVEGDAARHADAAFAARLSTMFDLQADPAAIGAHLARDAWFAPLVGAAPGLRVPGAWSGFELIVRAIVGQQVSVKAATTIVGRLVERAGERLAPHAPGAIGWRFPEPAALAACDVSRIGMPGKRAAALQGVARAVASGDVPLDAYASDPAGVRAALLALPGIGPWTVEYVAMRAWRDADAWPATDLVLMQAIVARDPALDRPASQRLRADAWRPWRAYAAMHLWNEIADRAGSARGG
>NZ_CP008758.1|WP_004190110.1|3797930_3799025_-|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada
MKQPPYPTDDARWAALVARDVDADGAFCYAVKTTGVFCRPSCASRLPRRENVSFFADTGAARAAGYRPCKRCRPEGLPRELDIVNRACAVLDAHRQDRFTLAQLSDAVHVSPFHLQRLFKRVVGVSPRQYQAAQRGAALRDALQSGAAVTRAAVDAGFNSPSRLYESVPRELGMSPSAFRRKGAGLKIDYATADTRLGVVLVAATSKGICKIAFGDAAAPLVDELRTGFANAQIAESPERIAPFIAQIDAYLNGTRRRFELPLDLAATEFQQRVWDALRRIPYGETRSYTQIAEALGAPRAVRAVASACASNPVALAIPCHRVVQKGGSLAGYRWGLPRKAALLDAEAQRAAGESVESAVDHAA
>NZ_CP008758.1|WP_004197761.1|3799426_3799843_+|VOC-family-protein
MKFHIHEIDHVVLRAADLAAMTRFYCDVLGCHVEKEQRELGLVQLRAGRSLIDLLAVGAPIDRAGSGAPGKGRNMDHLCLRVEPFDAAALRTHLAAHGARPGDEARRYGADGYGPSLYLFDPEGNMVELKGPPEAVAP
>NZ_CP008758.1|WP_004197759.1|3800039_3800594_-|YaeQ-family-protein
MALKSTIYKAELQIADMDRHYYADHSLTVARHPSETDERMMVRIAAFALFAHERLEFCKGLSDTDEPDLWQKDLTGAIEVWIDVGQPDERRIAKASGRAGRVNVIAYGGRTSDIWWQGARGKVERLRNVQVTTLADGVAAALGGLAERTMRLQCTIQDGAAWLSSATHDPVAIEWTTLKAREDA
>NZ_CP008758.1|WP_004536432.1|3800813_3801161_-|hypothetical-protein
MLKRTGLFLALAGGIVAFSVAQANGDASLKPQQEIQLTKNAWGCLSKDNLDSVLNHERDGKAQAKQQYFDDYRCLSVPEGQRFRVVSVDKGDVQFVSAENSDQQGLWTDARFIKQ
>NZ_CP008758.1|WP_004524603.1|3801646_3802207_-|spermidine-N1-acetyltransferase
MQIQNEQHTLALRPLERQDLRFVHELNNDAKIMRYWFEEPYETFTELSQLYDQHVHDQRERRFVAFDSDGELVGLVELIELDYIHRRGEFQIIIAPNRQGRGFATRATRLAVEYAFKVLNLRKLYLIVDKSNVAAIRVYEKCGFKHEAELIEEFFGNGQYHNALRMCIFQRDYFAAQPGAELHARE
>NZ_CP008758.1|WP_004524602.1|3802368_3802539_+|hypothetical-protein
MIEQVILGVFLVLPLLIVAVLYSDELWQEHRLQHPRDEHTPHIDWRHPWRILRRGH

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

305112 : 359115

Burkholderia_phage(26.32%)

plate,protease,transposase,integrase

attL 298301:298316|attR 335616:335631

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
298301:298316	attL	NA	NA	NA	NA
WP_004527881.1\|305112_305634_+\|protease	ClpXP protease specificity-enhancing factor	A0A1S5R3H3	Pseudomonas_phage	1.9e-21	51.0
WP_004536243.1\|305926_306757_+\|integrase	integrase arm-type DNA-binding domain-containing protein	B7SYF8	Stenotrophomonas_phage	1.7e-64	46.1
WP_009961431.1\|306906_308001_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_128972320.1\|308569_309187_+	hypothetical protein	NA	NA	NA	NA
WP_004536087.1\|309438_309651_+	AlpA family phage regulatory protein	A0A1V0E8E5	Vibrio_phage	1.8e-05	44.4
WP_004535788.1\|309660_311199_+	AAA family ATPase	NA	NA	NA	NA
WP_004535698.1\|311274_312420_+	hypothetical protein	NA	NA	NA	NA
WP_004535440.1\|312538_313624_+	inovirus-type Gp2 protein	NA	NA	NA	NA
WP_139341953.1\|314094_314694_+	hypothetical protein	NA	NA	NA	NA
WP_011854127.1\|315728_316124_+	DUF3775 domain-containing protein	NA	NA	NA	NA
WP_139341952.1\|316434_316989_+	hypothetical protein	NA	NA	NA	NA
WP_004536123.1\|317200_317857_-	hypothetical protein	NA	NA	NA	NA
WP_156605919.1\|317927_319691_-	hypothetical protein	A0A1L7N0M1	Ralstonia_phage	1.0e-50	31.6
WP_038745064.1\|319793_320147_-	hypothetical protein	NA	NA	NA	NA
WP_004536221.1\|320212_320470_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_004536016.1\|320479_320779_-	hypothetical protein	NA	NA	NA	NA
WP_004535673.1\|320906_321713_-	DUF4942 domain-containing protein	NA	NA	NA	NA
WP_009961431.1\|321866_322961_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_038709540.1\|323133_324222_-	hypothetical protein	NA	NA	NA	NA
WP_011854126.1\|324218_325151_-	hypothetical protein	NA	NA	NA	NA
WP_004535666.1\|325179_325413_-	hypothetical protein	NA	NA	NA	NA
WP_038709538.1\|325468_326464_-	YqaJ viral recombinase family protein	A6XMH8	Bacillus_virus	1.5e-51	39.1
WP_011854124.1\|326540_327509_-	DUF932 domain-containing protein	A0A0H4INH5	Stenotrophomonas_phage	3.8e-55	41.1
WP_154233053.1\|328518_328716_+	helix-turn-helix domain-containing protein	A0A1B1IUF9	uncultured_Mediterranean_phage	3.2e-17	60.7
WP_004535870.1\|328767_329817_+	DNA cytosine methyltransferase	A0A0R6PG08	Moraxella_phage	8.5e-109	55.8
WP_085962466.1\|329888_330299_+	very short patch repair endonuclease	V5UTF4	Oenococcus_phage	1.1e-11	42.6
WP_011854122.1\|330325_333463_+	DEAD/DEAH box helicase	A0A1B1IUI1	uncultured_Mediterranean_phage	1.3e-101	29.8
WP_038709532.1\|333459_334098_+	restriction endonuclease	NA	NA	NA	NA
WP_004535468.1\|334091_338477_+	hypothetical protein	A0A1B1IUC6	uncultured_Mediterranean_phage	1.1e-48	25.1
335616:335631	attR	NA	NA	NA	NA
WP_004536266.1\|338492_341624_+	DEAD/DEAH box helicase	A0A2H4J643	uncultured_Caudovirales_phage	1.6e-41	24.2
WP_004536371.1\|341620_343246_+	hypothetical protein	NA	NA	NA	NA
WP_004536073.1\|343242_347241_+	helicase	NA	NA	NA	NA
WP_004535816.1\|347243_349115_+	DUF1998 domain-containing protein	NA	NA	NA	NA
WP_038709528.1\|349116_349878_+	phospholipase	NA	NA	NA	NA
WP_038709525.1\|349874_351551_+	hypothetical protein	NA	NA	NA	NA
WP_038709523.1\|351642_352761_-	DUF3396 domain-containing protein	E5E3X7	Burkholderia_phage	6.4e-123	57.3
WP_038743760.1\|352766_353540_-	nuclease	A4JWV4	Burkholderia_virus	4.6e-43	43.3
WP_004535952.1\|353542_354073_-	PAAR domain-containing protein	A4JWV5	Burkholderia_virus	2.4e-51	60.0
WP_004525642.1\|354922_356143_+\|transposase	ISL3-like element ISBma1 family transposase	A9YX10	Burkholderia_phage	2.7e-239	99.8
WP_004521944.1\|356429_356756_+\|plate	baseplate assembly protein	K4NZR5	Burkholderia_phage	3.6e-50	96.2
WP_004535913.1\|357244_357661_+	DNA methylase	K4NZW3	Burkholderia_phage	7.1e-59	85.5
WP_111952238.1\|358055_358646_+	hypothetical protein	NA	NA	NA	NA
WP_004527840.1\|358749_359115_-	phage virion morphogenesis protein	K4NZQ8	Burkholderia_phage	2.5e-52	88.4

DBSCAN-SWA_2

1042249 : 1051106

Bacillus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004522358.1\|1042249_1043650_+	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	1.9e-79	38.5
WP_009921652.1\|1043681_1044605_+	D-glycero-beta-D-manno-heptose-7-phosphate kinase	A0A2H4N7X4	Lake_Baikal_phage	1.3e-15	27.1
WP_004190173.1\|1044663_1045656_+	ADP-glyceromanno-heptose 6-epimerase	R9S880	Prochlorococcus_phage	9.1e-28	30.9
WP_004189725.1\|1045727_1046045_+	helix-hairpin-helix domain-containing protein	NA	NA	NA	NA
WP_004550116.1\|1046386_1047289_+	cysteine synthase CysM	A0A1X9I5F1	Streptococcus_phage	3.3e-53	39.9
WP_004535581.1\|1047515_1048823_-	lytic murein transglycosylase B	NA	NA	NA	NA
WP_004188957.1\|1049001_1049925_+	histone deacetylase family protein	A0A2K9KZC4	Tupanvirus	8.4e-44	36.5
WP_004535490.1\|1050263_1051106_-	alpha/beta hydrolase	A7XCB7	Tanapox_virus	1.4e-16	26.6

DBSCAN-SWA_3

1571323 : 1579518

Burkholderia_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004535518.1\|1571323_1571587_+	hypothetical protein	Q8W6S4	Burkholderia_virus	5.0e-26	85.5
WP_076804731.1\|1571570_1571756_+	hypothetical protein	Q8W6S4	Burkholderia_virus	4.4e-21	85.2
WP_004534826.1\|1571776_1572502_-	immunity 52 family protein	A4PE26	Ralstonia_virus	1.7e-31	43.5
WP_038763587.1\|1572508_1573111_-	hypothetical protein	NA	NA	NA	NA
WP_004527237.1\|1573452_1573959_-	DUF4123 domain-containing protein	A4PE24	Ralstonia_virus	5.1e-19	40.1
WP_004527236.1\|1573955_1574381_-	PAAR domain-containing protein	A4JWV5	Burkholderia_virus	3.8e-15	49.4
WP_009937072.1\|1574661_1575057_-	hypothetical protein	NA	NA	NA	NA
WP_004531416.1\|1575310_1575538_+	hypothetical protein	Q8W6S4	Burkholderia_virus	3.8e-22	75.8
WP_004527234.1\|1575573_1575807_-	immunity 52 family protein	A4PE26	Ralstonia_virus	4.3e-13	60.6
WP_004550288.1\|1575882_1576344_-	avidin	NA	NA	NA	NA
WP_004527233.1\|1577281_1577464_+	hypothetical protein	NA	NA	NA	NA
WP_004193371.1\|1577590_1578214_-	phospholipase D family protein	NA	NA	NA	NA
WP_004527232.1\|1578408_1579518_-	class II histone deacetylase	A0A2K9L2T7	Tupanvirus	3.1e-37	31.6

DBSCAN-SWA_4

2979014 : 2989969

Agrobacterium_phage(16.67%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004196461.1\|2979014_2981315_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	5.1e-167	42.1
WP_004194131.1\|2981311_2981626_-\|protease	ATP-dependent Clp protease adapter ClpS	A0A218MMY6	uncultured_virus	4.4e-13	44.6
WP_004196460.1\|2982158_2982362_+	cold-shock protein	A0A2H4N7Y6	Lake_Baikal_phage	6.8e-23	81.8
WP_004536101.1\|2982491_2984102_-	multicopper oxidase family protein	NA	NA	NA	NA
WP_004189626.1\|2984114_2984297_+	hypothetical protein	NA	NA	NA	NA
WP_004189552.1\|2984269_2985529_-	NADP-dependent isocitrate dehydrogenase	Q77Z09	Phage_21	5.2e-12	63.0
WP_004189780.1\|2985796_2986375_+	pseudouridine synthase	NA	NA	NA	NA
WP_071810810.1\|2986637_2986856_+	hypothetical protein	NA	NA	NA	NA
WP_004530837.1\|2987047_2987557_+	DUF192 domain-containing protein	A0A1B1IUW8	uncultured_Mediterranean_phage	5.5e-13	41.2
WP_004197486.1\|2987854_2989969_+	elongation factor G	E4ZFJ7	Streptococcus_phage	5.8e-56	26.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP008759

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP008759_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP008759_1

1402853-1402945

Orphan

Consensus_repeat	Method
TCGCCGCCGCGCGCGACGACGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP008759_1

>merge|NZ_CP008759|1|1402853-1402945|CRISPRCasFinder
TCGCCGCCGCGCGCGACGACGCGCTGAAGGACGCGCTCGCGCAGGCCGCCGCCGAGCGCGAGCGGCTGATCGCCGCCGCGCGCGCCGACGCGC

>NZ_CP008759|1|1|1402853-1402945|CRISPRCasFinder
TCGCCGCCGCGCGCGACGACGCGC	TGAAGGACGCGCTCGCGCAGGCCGCCGCCGAGCGCGAGCGGCTGA
TCGCCGCCGCGCGCGCCGACGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP008759.1\|WP_004537128.1\|1407574_1408090_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008759.1\|WP_004188221.1\|1400439_1400895_+\|F0F1-ATP-synthase-subunit-epsilon	unknown	unknown	gnl\|CDD\|184057
NZ_CP008759.1\|WP_004524993.1\|1413085_1414210_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NZ_CP008759.1\|WP_004524989.1\|1408147_1408657_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008759.1\|WP_004529174.1\|1411100_1412936_-\|response-regulator	unknown	unknown	gnl\|CDD\|237425
NZ_CP008759.1\|WP_004188840.1\|1396709_1398503_-\|polyhydroxyalkanoic-acid-synthase	unknown	unknown	gnl\|CDD\|213656
NZ_CP008759.1\|WP_004187346.1\|1401687_1402389_+\|F0F1-ATP-synthase-subunit-A	unknown	unknown	gnl\|CDD\|237383
NZ_CP008759.1\|WP_004524995.1\|1417409_1418483_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|235136
NZ_CP008759.1\|WP_004187193.1\|1402385_1402634_+\|F0F1-ATP-synthase-subunit-C	unknown	unknown	gnl\|CDD\|184067
NZ_CP008759.1\|WP_004524980.1\|1395295_1396699_-\|bifunctional-enoyl-CoA-hydratase/phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|236180
NZ_CP008759.1\|WP_004529180.1\|1405377_1406226_+\|F0F1-ATP-synthase-subunit-gamma	unknown	unknown	gnl\|CDD\|376304
NZ_CP008759.1\|WP_004529187.1\|1391402_1392050_+\|BON-domain-containing-protein	unknown	unknown	gnl\|CDD\|225379
NZ_CP008759.1\|WP_004198321.1\|1406484_1407510_+\|alcohol-dehydrogenase-AdhP	unknown	unknown	gnl\|CDD\|176257
NZ_CP008759.1\|WP_004524985.1\|1401382_1401691_+\|membrane-protein	unknown	unknown	gnl\|CDD\|274462
NZ_CP008759.1\|WP_004536508.1\|1392064_1393393_+\|1-phosphofructokinase-family-hexose-kinase	unknown	unknown	gnl\|CDD\|238570
NZ_CP008759.1\|WP_004529183.1\|1398863_1400450_+\|F0F1-ATP-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|183615
NZ_CP008759.1\|WP_004530238.1\|1403380_1405381_+\|F0F1-ATP-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|183987
NZ_CP008759.1\|WP_004529184.1\|1394120_1395299_-\|acetate/propionate-family-kinase	unknown	unknown	gnl\|CDD\|235922
NZ_CP008759.1\|WP_004537465.1\|1414212_1417413_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP008759.1\|WP_004524990.1\|1409197_1410763_+\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|185008

Protein	Function_ID	Function_description	E-value
NZ_CP008759.1\|WP_004188221.1\|1400439_1400895_+\|F0F1-ATP-synthase-subunit-epsilon	gnl\|CDD\|184057	PRK13447, PRK13447, F0F1 ATP synthase subunit epsilon; Provisional.	4.44077e-63
NZ_CP008759.1\|WP_004524993.1\|1413085_1414210_-\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	3.93708e-26
NZ_CP008759.1\|WP_004529174.1\|1411100_1412936_-\|response-regulator	gnl\|CDD\|237425	PRK13557, PRK13557, histidine kinase; Provisional.	4.08999e-132
NZ_CP008759.1\|WP_004188840.1\|1396709_1398503_-\|polyhydroxyalkanoic-acid-synthase	gnl\|CDD\|213656	TIGR01838, Poly-beta-hydroxybutyrate_polymerase, poly(R)-hydroxyalkanoic acid synthase, class I. This model represents the class I subfamily of poly(R)-hydroxyalkanoate synthases, which polymerizes hydroxyacyl-CoAs with three to five carbons in the hydroxyacyl backbone into aliphatic esters termed poly(R)-hydroxyalkanoic acids. These polymers accumulate as carbon and energy storage inclusions in many species and can amount to 90 percent of the dry weight of cell. [Fatty acid and phospholipid metabolism, Biosynthesis].	6.3979e-179
NZ_CP008759.1\|WP_004187346.1\|1401687_1402389_+\|F0F1-ATP-synthase-subunit-A	gnl\|CDD\|237383	PRK13421, PRK13421, F0F1 ATP synthase subunit A; Provisional.	1.54059e-122
NZ_CP008759.1\|WP_004524995.1\|1417409_1418483_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|235136	PRK03598, PRK03598, putative efflux pump membrane fusion protein; Provisional.	1.83012e-39
NZ_CP008759.1\|WP_004187193.1\|1402385_1402634_+\|F0F1-ATP-synthase-subunit-C	gnl\|CDD\|184067	PRK13468, PRK13468, F0F1 ATP synthase subunit C; Provisional.	4.45015e-37
NZ_CP008759.1\|WP_004524980.1\|1395295_1396699_-\|bifunctional-enoyl-CoA-hydratase/phosphate-acetyltransferase	gnl\|CDD\|236180	PRK08190, PRK08190, bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated.	0
NZ_CP008759.1\|WP_004529180.1\|1405377_1406226_+\|F0F1-ATP-synthase-subunit-gamma	gnl\|CDD\|376304	pfam00231, ATP-synt, ATP synthase.	1.01746e-33
NZ_CP008759.1\|WP_004529187.1\|1391402_1392050_+\|BON-domain-containing-protein	gnl\|CDD\|225379	COG2823, OsmY, Predicted periplasmic or secreted lipoprotein [General function prediction only].	4.08279e-23
NZ_CP008759.1\|WP_004198321.1\|1406484_1407510_+\|alcohol-dehydrogenase-AdhP	gnl\|CDD\|176257	cd08297, CAD3, Cinnamyl alcohol dehydrogenases (CAD). These alcohol dehydrogenases are related to the cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Cinnamyl alcohol dehydrogenases (CAD) reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NZ_CP008759.1\|WP_004524985.1\|1401382_1401691_+\|membrane-protein	gnl\|CDD\|274462	TIGR03165, F1F0_chp_2, F1/F0 ATPase, Methanosarcina type, subunit 2. Members of this protein family are uncharacterized, highly hydrophobic proteins encoded in the middle of apparent F1/F0 ATPase operons. We note, however, that this protein is both broadly and sparsely distributed. It is found in about only about two percent of microbial genomes sequenced, with the first ten examples found coming from the Euryarchaeota, Chlorobia, Betaproteobacteria, Deltaproteobacteria, and Planctomycetes. In most of these species, surrounding operon appears to represent a second F1/F0 ATPase system, and the member proteins belong to subfamilies with the same phylogenetic distribution as the current protein family.	4.12229e-10
NZ_CP008759.1\|WP_004536508.1\|1392064_1393393_+\|1-phosphofructokinase-family-hexose-kinase	gnl\|CDD\|238570	cd01164, FruK_PfkB_like, 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose 6-phosphate pathway, which responsible for breakdown of the galactose moiety during lactose metabolism by bacteria such as L. lactis.	1.30521e-109
NZ_CP008759.1\|WP_004529183.1\|1398863_1400450_+\|F0F1-ATP-synthase-subunit-beta	gnl\|CDD\|183615	PRK12597, PRK12597, F0F1 ATP synthase subunit beta; Provisional.	0
NZ_CP008759.1\|WP_004530238.1\|1403380_1405381_+\|F0F1-ATP-synthase-subunit-alpha	gnl\|CDD\|183987	PRK13343, PRK13343, F0F1 ATP synthase subunit alpha; Provisional.	0
NZ_CP008759.1\|WP_004529184.1\|1394120_1395299_-\|acetate/propionate-family-kinase	gnl\|CDD\|235922	PRK07058, PRK07058, acetate/propionate family kinase.	0
NZ_CP008759.1\|WP_004537465.1\|1414212_1417413_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.91562e-92
NZ_CP008759.1\|WP_004524990.1\|1409197_1410763_+\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|185008	PRK15048, PRK15048, methyl-accepting chemotaxis protein II; Provisional.	2.47951e-79

>NZ_CP008759.1|WP_004187193.1|1402385_1402634_+|F0F1-ATP-synthase-subunit-C
MNNLIEVVSIAAAALAVSFGAIGPALAEGRAVGAAMDAIARQPDASGTVSRTLFVGLAMIETMAIYCLVVALLLLFANPFVK
>NZ_CP008759.1|WP_004187346.1|1401687_1402389_+|F0F1-ATP-synthase-subunit-A
MNASPLSTVPLFSVGPVGISAPVLATWAIMAVLVALALVARRRLSVDAPSRLQSVLELFVATVDAQIADTMQTPPARYRALIGTIFVLVFCANGASLVPGVEPPTAHLETDAALALVVLAATLYYGVRARGVRGYLATFAEPTWVMIPLNVVEQLTRTFSLIVRLFGNVMSGVFVIGIVLSLAGLFVPIPLMALDLLTGTVQAYIFMVLSMVFIGAAVSGDETSAPRRGQENT
>NZ_CP008759.1|WP_004524985.1|1401382_1401691_+|membrane-protein
MIEMWETARASFDGIAAAIGLALGFVAGACHFVSLGWNSRLFVAGRAGVALALQLARVALAVAVLVVLARAGFGMLVAGSAGFFAARAIAVRRAAALTGARR
>NZ_CP008759.1|WP_004188221.1|1400439_1400895_+|F0F1-ATP-synthase-subunit-epsilon
MGAELRVTIATPARVCVDDLPIVSLRAEDASGAFGIRAGHVDFVTLLRASVVRWRTADGATHYAALDGGVLRVTRGARIEIACRDAVLGESLAELEAVVRGVRATQLDEKRRARVDETRLHAQAVRRLLTYLRPEHAKDGVHAPLKPETLE
>NZ_CP008759.1|WP_004529183.1|1398863_1400450_+|F0F1-ATP-synthase-subunit-beta
MADPQATNGTGAACAERDASDVGDARDEGAGRVVAVRGAVIDVAFDGGALPALNEALTIPVDGAAPILAEVHAHLSDAAVRALALGPTGGLRRGAAVRATGGPIRVPVGDAVLGRLLSVTGAPGDDGAALAADVERRPIHRGAPLLAEQKSANALFATGIKVIDLLAPLAQGGKAAMFGGAGVGKTVLVMELIHAMVERYRGISVFAGIGERSREGHEMLLDMRGSGVLGRTVLVYGQMNEPPGARWRVPLTALAIAEYFRDERAQNVLLLMDNVFRFVQAGAEVSGLLGRLPSRVGYQPTLASEVAALQERIASVEGAAVTAIEAVYVPADDFTDPAVTAIAAHVDSMVVLSRAMAAEGMYPAIDPVASSSILLDPLVVGEAHVEVAIEVRRVIEHYRELQDVIALLGIDELGADDRRLVGRARRLQRFLTQPFAVTEAFTGQAGASVEIADTIAGCRAILRGDCDDWRESSLYMVGTLDDARRKEAAAREADARREAAAAASGAGPGTTSDPASGSAEPQGARHGR
>NZ_CP008759.1|WP_004188840.1|1396709_1398503_-|polyhydroxyalkanoic-acid-synthase
MDTRHAPESGAPDAPLPAHPPASYAPESPYRIFDLAKEASVAKLTSGLSPASLQLALADWLIHLAAAPGKRAELATLALRHAALLGQYLLEAATGRTPAAPAQPSPGDRRFRAGAWQLEPYRFWHQSFLLAEQWWRAATRDVPGVSPHHEDVVAFSARQMLDTFAPANYVATNPEIAQRTALTGGANLAQGVWNYLDDVRRLITKQPPAGAEQFELGRNLATTPGRVVFRNHLIELLQYSPTTPDVYAQPVLIVPAWIMKYYILDLSAHNSLIRYLVGEGHTVFCISWRNVDASDRDLSLDDYRKLGVMDALDTIGAIVPGEKIHATGYCLGGTLLSIAAAAMANTGDDRLASITLLAAQTDFAEPGELQLFIDDSEIHFLESMMWERGYLGAHQMAGSFQLLMSNDLIWSRVIHDYLLGERTPMIDLMAWNADSTRMPYRMHSEYLRHLFLDNDLATNRYVIDGQTVSVHNIRAPFFVVGTEHDHIAPWRSVYKIHYLSGSDVTFVLTAGGHNAGIVSEPGHAKRHYRMKMTAAAAPSISPDEWLAGATDFEGSWWPAWHAWLARHSSPQRVAPPPLGKPGAHTLGDAPGTYVFQK
>NZ_CP008759.1|WP_004524980.1|1395295_1396699_-|bifunctional-enoyl-CoA-hydratase/phosphate-acetyltransferase
MDREILQNRPFDSLAIGDSASLVRTASRDDIDLFAAMSGDVNPAHLDAAFAAHDLFGHVVVHGMWTGALVSAVLGTKLPGPGTIYLDQTLEFRHPVAPGDTITATVTVAEKRPEKRIVLLDTRCTNQDGHVVLRGTATVIAPDTPITWERVPGPEVAVRRHDRYETFVRDAREQPPLRTAIVHPCSPDALRAAIDARDANLIEPILIGPQAKIRAIADAAGVDLAGVPIEAVEHSHAAAARAVEMGGAGEVAALMKGSLHTDELLAAVIGPASRLRTERRISHVYAMDVPAYPKPLLITDAAINIAPTLEQKRDICQNAVDLLHVLGVERPRVAVLAAVETVNPKMPSTLDAAALTVMAARGQIAGAIVDGPLAFDNAVSAVAAMSKGIASPVAGDADVLLVPDLEAGNMLAKQLMYFAGADAAGLVLGARLPIILTSRADSLRVRIASAALAKLVAERTRAGALAS
>NZ_CP008759.1|WP_004529184.1|1394120_1395299_-|acetate/propionate-family-kinase
MSEPLLLTFNAGSSTLKIGLYSVANGEPAPLGRGKIDFNRAPLQFEYANGGEAHAVPLAAPVTDDLHAVLDEALGWIDAHLSVHELVSVGHRVVHGGDTFDGPVRIDERTLDAIAALVPLAPLHQPQSVRLIRALRHLRPHLPQVASFDTAFHRTQSDLVRRFALPRALFDAGIKRYGFHGLSYRYVAGRLRERHPSIARGKVVAAHLGSGASLCALDAGVSRDTSMGFSTLDGIPMATRCGALDAGVVLHLQKTLGRTLDDVEQMLYHRSGLLGVSGVSGDARALLADPSAGARDALELFAFRIAGETARLAATLGGLDALVFTAGIGEHQPQTRAAVCERLRWLGVELDAHANARNAETVSRDGSRVAVLVVPTDEEQVIARDAASVLHA
>NZ_CP008759.1|WP_004536508.1|1392064_1393393_+|1-phosphofructokinase-family-hexose-kinase
MRGACASRAMFDTGGKRQAASGKRQAASGKRQAASGKRQAASGKRQAASGKQQAASSKQQAASSKQQAASSKQQAASSSRSSPGLMVRRRIERKHCGACPPRSTREPRTRASRCVVFPSRIPTLKPNVTMPEIVTLTPNPAIDVATCVERVTDTRKLRCGPARRDPGGGGINVARVLTRLGADCSAVYLAGGGTGLALRGLLADEGVRAHGIDIAGETRENFSVLETSTGREFRFVLPGPALAAHEWPRCVEALGRLADASRYLVMSGSLPPGMPDDCYARLARRASARGVRTVVDTSGPALAAALDAGVYLVKPSLGELRALTGLPLEDDGARLAAARAIVAGGRAQIVALTLGDAGALVVSRDDAVRLPGVKVAVRSAIGAGDSFVAGLVAALNRGANVADAARHALAAASASLLSTGTALGTKEDIARIYRELPGMIDA
>NZ_CP008759.1|WP_004529187.1|1391402_1392050_+|BON-domain-containing-protein
MKSDAALKQDVEQELYWDPSLDARQIDVSVRDRIVTLRGFVPSWAQKYAAQKAAQRVAGARALVLELKVLPSEAPRDDEVLAAAIVSALAWQEALAGQEIHVDVDEGCVTLTGEVAFGYQRQAAETVVSRMRGVIGVVNRIDVRSRDAGATVRERVADALARRAQREAAHIEVDERDGIVTLTGTVDSLIERRAACGAAWSVKGVREVIDHLSVA
>NZ_CP008759.1|WP_004530238.1|1403380_1405381_+|F0F1-ATP-synthase-subunit-alpha
MTPTPDAPAAADADAATGAGWLARRRGALARVALAPVAQAIGRVERVADGIAFVSGLEDTMLNEVLRFEGGVTGFAHTLDEDLISVVLLDPDAGVRAQTAVARTGAVLEVPAGPQLLGRVVDPLGRPLDGGAPLDAAHTLPIERAAPAIIERDLVSEPLDTGVLIVDALFTIGRGQRELIIGDRATGKTSLAIDAIVNQRHSDVICVYVAIGQRASAVRRVIDAVRRYGAPERCVFVVAPAACAPGLQWIAPFAGFSIAEYFRDRGQHALVVVDDLTKHAATHRELALLTREPPGREAYPGDIFYVHARLLERAAKLSAALGGGSLSALPIAETDAGNLAAYIPTNLISITDGQIVLDSALFAANQRPAVDVGLSVSRVGGKAQHPALRAASGRLRLDYAQFLELEAFTRFGGLTDARLRAQITRGERIRALITQPRFRALRTLDEVVLLKALAAGALDAMSPDLVAPLRERLPAWLDARIAALTPALAPPRDWLADDAALDALAESVGELIERIAADAARRATAGMPAEDAAGDIGGAFGGEQARGDADRDADHGANREVSREVSPEASREVSREVSCEVSHEADRDAAADAARVAGRAPGRAEPDRAAPRAMPDGPPRAQADGDRASASRPRPDARGDAARTAPSPQGGADANVDAEAEARHKR
>NZ_CP008759.1|WP_004529180.1|1405377_1406226_+|F0F1-ATP-synthase-subunit-gamma
MSDKLAAIEARTDTARQLQTVIGAMQGVAAARAHEAQQRLPGIRASAATVGAAIGDALSAGARSGDTAAGARAAPRARLVVVLCSEQGFVGAYNAQLIEHATRPEPSVSREYMMVGSRGAMLADAGGVPLVWRTPMAARADDVVHLANRITDALYAHLAKRGAQPVSIVHAMPGGAARLEATERRLLPFDYARFDTAPRAQPPLVHLPPATLLAELAQAYVFVELCEAAMLAFAAENEARTRAMIAARESVERALGDLLQAYRIARQDEITADIVELAASGL
>NZ_CP008759.1|WP_004198321.1|1406484_1407510_+|alcohol-dehydrogenase-AdhP
MAQYMKAAVVHAFGEPLRIEEVPVPTPGAGQILVNVKASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGFVAAVGEGVRHVKEGDRVGVPWLYTACGHCEYCQTGWETLCHEQQNTGYSVNGSYAEYVLADPNYVGHLPSNVAFDEIAPILCAGVTVYKGIRVTDTRPGQWIAISGIGGLGHVAVQYAKAMGLHVVAVDVAPQKLELARKLGATFVVDASKDDPAAVIQKEIGGVHGVLVTAVSRGAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESLDFAAEGLVRAHIHRDKLEHINGVFSALREGKVDGRIVLTGQ
>NZ_CP008759.1|WP_004537128.1|1407574_1408090_+|hypothetical-protein
MRRAMRGAGRASPSRARRYENVSKEPNTHREARAPVHRYRLQVRNMNGECRTYELRLSSLDDGYTLEIDEWLNFPDMHPGDVTPVHVSRPVQFAVPAHEFYRRRRAFRTELIESVAAALRAGEVVRMRDSPDEYPGGHAGNPWVNWIRADLRANPGGRPPPVGDDMQDLIH
>NZ_CP008759.1|WP_004524989.1|1408147_1408657_-|hypothetical-protein
MRRIYFLLPDADTARAIVDELLLKRIEWRHIHVVANDRVPLENLPEASIAQSSDLLPALARGTAAGGVTGALAGLAAIAFPPAGLTIAGGAVVAFAIAGAGFGAWVGTMIGVSVPNTRLKHFEDAVDNGELLMMIDVHRDRVEEIEALVKQHHPNAHLEGTDPTIPAFP
>NZ_CP008759.1|WP_004524990.1|1409197_1410763_+|methyl-accepting-chemotaxis-protein
MPTLSFRQKLWLPLVISLIALLLVSISSAWLSYQTRMEERRNDLTNVAHVGLSIVREYAALAQRGVLTDAQARKEALERLRSVRYGSDGYFIVIDSSPRMIMHPIKPDTVGKDLRHVADADGRHHYLTFASVAQSPQGGFVDYVFAHPNAHPAKAVDKLGYVIRYAPWDWIISTGAYIDDIQAAFAKSLCLSAGVFALLAALLALSVVYTNRGIERMIGGDPRIAAHMAGVIASGDLATPFATRREDRSSLMFAISQMRDALANAVAQIRASAGYVATTAGEIADSNMDLSSHTECQATALQQAASSMQRLTERVRDTADRARAASELAGSAARITDRGGDMVVRVVAAMNDIRAESRKMVDIIGVIEGIAFQTNILALNAAVEAARAGNEGRGFAVVASEVRVLAQRSASAAKDIRALIGRAAERVGNGAELVEATGATIGEAQHAICRVTGIVQDIAAAATDQSQGLEQINAAVSQMDSVTRRNATLVEHAAIAAQSLNEQSRCLQDAVAAFRTEALGC
>NZ_CP008759.1|WP_004529174.1|1411100_1412936_-|response-regulator
MHVEVFAQHPSCPGWHGEMARRIRAFDWSATELGPLERWPASLVAAVRTVLASPVPLVMLWGASGYMLYNDAYAAFAGGRHPYLLGQPVELGWPEVADFNRNVMRTCLAGGALSYRDKALVLLRNGRPEEVWMDLYYSPLAGDDGAPAGVLAVVVETTERVLAARHRDRAKAALHETNAELRRLTETLEQRVADAITERASIEEQLRQAQKMEAIGSLTGGIAHDFNNVLQVVSSNLQMLSAELGEDARAQRRIASAANAVARGAQLASHLLAFARRQPLAPAVLEPRGLIDGMREMLHRALGESVHVDADLRDDVWNVLADRHQFENALLNLAINARDAMRGEGTLKITACNIVLEAGRHARRNGLPPGEYVAFDIADNGVGMTPDILERVFEPFFTTKPDGQGTGLGLSMVFGFVKQSGGHTSIESAPGRGTTVRLLLPRCREAPAGEPAAQRRLPAEGGRETILVVEDDADVRLAVVDMLAQLGYKVITASDGEAGLLALESGAPIDLLFTDVIMPGRIKGGELARRAAQRVPPVPVLFTSGYTRDEIFHAGRLDPGVMLLGKPYRRDELAHKVRSVLDAHASARRAHGARHAQADPRAKTAAARVQR
>NZ_CP008759.1|WP_004524993.1|1413085_1414210_-|ABC-transporter-permease
MRRLAIVYRLGVKELWSLVRDPILLVLIAYTFTASIYSAATARPDTLHMAPIAIIDEDASPLSARIASAFFPPQFALPRMVTLAEADRGMDAGDFTFALDIPPNFQRDVLAGRPAQIQLNVDATRMSQAFTGNGYVQQIVSGEIDDFARRYRANTAPPVDIAMHMRFNPNLDQTWFGSLMEVINNVTLLSMVLTGAALIREREHGTIEHLLVMPVTPGEIMLAKVWSMGLVVACAAAFSLAFVVRGALHVPIEGSVALFVIGMAIHLFATTSMGIFLATLVRSMPQFGMLLVLVLLPLQLLSGSLTPRESMPFAVQNIMLAAPTTHFVEIGQAILYRGAGIETVWRQFLILAVIGTALFLLSLKRFRKTIGQMA
>NZ_CP008759.1|WP_004537465.1|1414212_1417413_-|ATP-binding-cassette-domain-containing-protein
MSAPSVVRFSDVSLRYGKTVALERITLEIPAGLTIGLIGPDGVGKSSLLALAAGARALQTGAVDALGGDMRSRRHRERVCRRIAYMPQGLGKNLYPTLSVEENLQFFARLFGHDADERRRRIDALTRSTGLFAFLSRPAGKLSGGMKQKLGLCCALIHDPDLLILDEPTTGVDPLARAQFWDLIARIRSERPAMSVIVATAYMDEAQRFDWLIAMDAGRVLATGAPAELLARTGCDSLEAAFIALLPEDERRGHKPVTLEPLRADAQTGTAIEARGLTMRFGDFTAVDHVSFRIRRGEIFGFLGSNGCGKSTTMKMLTGLLPATEGTAQLFGKTVDPKDINTRRRVGYMSQAFSLYSELTVRQNLVLHARLFGVPAAEIDARVDEMARRFGLADIYDMLPDSLPLGMRQRLSLAVAMVHKPELLILDEPTSGVDPVARDSFWQLMIDLARRDRVTIFISTHFMNEAQRCDRISLMHAGRVLASDAPAALVRARGAATLEEAFIGYLVDASAQEAQGGAGERPGAGERAAGESVAGRGAASDGDADGAHARPAAYANGAAQHRAPDADAAGTDVAAETGARDDARTAHAAGHSAGNDVRATVGSEVGSEVGSEAGLAAGAESGSEHAREPAADAGAAIDVEPGASAESATAAVAPARHAESAATSPRAGNAPAGTPFAAAPPSHAAPAEPPHRAFSAQRALSYMWREMLELRRDPVRATLALIGSLVLMCVIGIGISLDVEDLTYAVLDRDQTELSHDYALNLSGSRYFVERPPIADYAALDRRMRDGELSLAIEIPPNFARDVERGAPAQIGMWIDGAMPQRAETIRGYAIGMHTMWLADKARHRLGVTLAPRAEVVTRYRYNPDVKSLPAMIPAVMPLLLLMLPAMLTALAVVRERELGSILNLYVTPVTRTEFLIGKQVPYVVLAMLNFLLMTMLARIAFDVPVKGSFMTLLLAVLIFNVVATGIGLLASTFTRSQVAAIVMTIIGTMIPTVQFAGLLTPLSSLEGTGRLIGLVYPATYMLSISRGVFNKALSLHELYSQFWPLAACVPVILGATILLLKKQER
>NZ_CP008759.1|WP_004524995.1|1417409_1418483_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MIQVTRKQIVAAAAVVVVALGAYYGWTLLRHQGPGDGFASGNGRIEATEIDVATKLPGRIDAILVDEGDFVKAGQPLANMQIQVLRAQYDEATAQRQRALNTAAGVQSQVAQRKSDKAAAQAMVVLRESELDAAERRLARSQTLSREGASSLQELDDDRARARSAQAAVSAAAAQVAAAQAAIEATEAQLVAAHSAVTAADATVARVQADIDDSQLASPRDGRVQYRVAQPGEVLPAGGKVLNLVDLSDVYMTFFLPETVVGRVALGADARIILDAAPNYVIPATVSFVSSTAQFTPKTVETANERQKLMFRVKARIDRELLQKHLKLVKTGLPGVAWVRVDPSKPWPAQLMVKVPQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

136702 : 204458

Aeromonas_phage(25.0%)

holin,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004530063.1\|136702_137653_-\|holin	choline ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_004186852.1\|137920_138865_+	GlxA family transcriptional regulator	NA	NA	NA	NA
WP_004536787.1\|139336_141040_+	peptidase	NA	NA	NA	NA
WP_004536719.1\|141157_142384_+	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
WP_004200640.1\|142438_143581_-	porin	NA	NA	NA	NA
WP_004530058.1\|143808_144846_-\|holin	choline ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_004537371.1\|144842_146396_-\|holin	choline-sulfatase	NA	NA	NA	NA
WP_011857652.1\|146558_147437_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_004186920.1\|147580_148456_+	formyltetrahydrofolate deformylase	NA	NA	NA	NA
WP_004530057.1\|148542_150198_-	APC family permease	NA	NA	NA	NA
WP_004186918.1\|150378_151242_-	glycine betaine ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_004530056.1\|151351_152497_-	hybrid-cluster NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_004523139.1\|152517_153786_-	aromatic ring-hydroxylating dioxygenase subunit alpha	NA	NA	NA	NA
WP_004530055.1\|153810_154596_-	drug:proton antiporter	NA	NA	NA	NA
WP_004536839.1\|154592_155765_-	electron transfer flavoprotein subunit alpha/FixB family protein	NA	NA	NA	NA
WP_004536637.1\|155769_157695_-	(Fe-S)-binding protein	NA	NA	NA	NA
WP_004186960.1\|157697_159761_-	NADH:flavin oxidoreductase	NA	NA	NA	NA
WP_004186987.1\|159821_160355_-	4-vinyl reductase	NA	NA	NA	NA
WP_004535113.1\|160505_161477_-	membrane dipeptidase	NA	NA	NA	NA
WP_004523136.1\|161549_162824_-	serine hydroxymethyltransferase	A0A219Y950	Aeromonas_phage	5.3e-105	54.1
WP_009933096.1\|162835_163087_-	hypothetical protein	NA	NA	NA	NA
WP_004198247.1\|163256_164282_+	GlxA family transcriptional regulator	NA	NA	NA	NA
WP_004523135.1\|164459_165659_-	formaldehyde dehydrogenase, glutathione-independent	A0A2K9L7I1	Tupanvirus	8.4e-12	27.2
WP_004523134.1\|166098_167115_-	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_004537403.1\|167384_168869_+	glycoside hydrolase family 68 protein	NA	NA	NA	NA
WP_004536832.1\|169001_170666_+	glycoside hydrolase family 32 protein	F8WPR5	Bacillus_phage	7.0e-57	31.6
WP_025988348.1\|171188_172442_-	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_004532078.1\|173180_174764_-	efflux transporter outer membrane subunit	NA	NA	NA	NA
WP_004536569.1\|174760_174943_-	hypothetical protein	NA	NA	NA	NA
WP_004535065.1\|175068_176064_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_004542407.1\|176316_177900_-	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
WP_004524287.1\|177896_179216_-	glycosyltransferase	NA	NA	NA	NA
WP_011857649.1\|179105_179408_+	hypothetical protein	NA	NA	NA	NA
WP_004528661.1\|179449_180349_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_004536812.1\|180899_181175_-	hypothetical protein	NA	NA	NA	NA
WP_004190471.1\|181495_181921_-	hypothetical protein	NA	NA	NA	NA
WP_004190863.1\|181943_182303_-	hypothetical protein	NA	NA	NA	NA
WP_004525554.1\|182361_185865_-	type VI secretion system membrane subunit TssM	NA	NA	NA	NA
WP_004525553.1\|185861_187520_-	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_004525552.1\|187602_188964_-\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_004530042.1\|188960_189554_-	type VI secretion lipoprotein TssJ	NA	NA	NA	NA
WP_004190606.1\|189559_189949_-	DUF4150 domain-containing protein	NA	NA	NA	NA
WP_004530790.1\|189991_190708_-	DUF3540 domain-containing protein	NA	NA	NA	NA
WP_004525550.1\|190710_191781_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_004537649.1\|191780_193997_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_004190563.1\|194000_196289_-	type VI secretion system tip protein VgrG	NA	NA	NA	NA
WP_004536618.1\|196454_198746_-	type VI secretion system tip protein VgrG	NA	NA	NA	NA
WP_004525547.1\|198736_201607_-	type VI secretion system ATPase TssH	A0A2I7REQ1	Vibrio_phage	2.4e-60	27.2
WP_004190851.1\|201609_202599_-\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_004196180.1\|202595_204458_-\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA

DBSCAN-SWA_2

368106 : 371753

Burkholderia_virus(85.71%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004525420.1\|368106_368391_-	BrnA antitoxin family protein	K4NZP3	Burkholderia_phage	1.4e-10	50.0
WP_009939402.1\|368374_368548_-	BrnT family toxin	NA	NA	NA	NA
WP_004537565.1\|369215_369491_+	bacteriophage protein Gp49	Q6JIH4	Burkholderia_virus	5.2e-42	95.6
WP_004552958.1\|369770_369947_+	hypothetical protein	Q6JIH7	Burkholderia_virus	2.3e-27	100.0
WP_009946438.1\|369975_370323_+	hypothetical protein	Q6JIH8	Burkholderia_virus	3.8e-58	100.0
WP_004549687.1\|370370_370589_+	hypothetical protein	Q6JIH9	Burkholderia_virus	5.7e-36	100.0
WP_009946442.1\|370763_371354_-	hypothetical protein	A4JX33	Burkholderia_virus	1.3e-101	96.9
WP_004529911.1\|371444_371753_+	hypothetical protein	Q6JII2	Burkholderia_virus	1.2e-50	100.0

DBSCAN-SWA_3

1200746 : 1266509

Ralstonia_phage(22.22%)

transposase,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004533421.1\|1200746_1202150_+\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_004190689.1\|1202165_1203482_+	DotU family type VI secretion system protein	NA	NA	NA	NA
WP_004524806.1\|1203484_1207114_+	type VI secretion system membrane subunit TssM	NA	NA	NA	NA
WP_004537697.1\|1207095_1208079_+	type VI secretion system-associated protein TagF	NA	NA	NA	NA
WP_004529325.1\|1208063_1208291_-	hypothetical protein	NA	NA	NA	NA
WP_011857734.1\|1208289_1210875_+	serine/threonine protein kinase	M1I231	Acanthocystis_turfacea_Chlorella_virus	5.0e-09	26.6
WP_004529323.1\|1210927_1212007_+	type VI secretion system protein TssA	NA	NA	NA	NA
WP_004524810.1\|1212069_1212648_+	type VI secretion system contractile sheath small subunit	NA	NA	NA	NA
WP_004190849.1\|1212640_1214149_+	type VI secretion system contractile sheath large subunit	NA	NA	NA	NA
WP_004190698.1\|1214208_1214700_+	type VI secretion system tube protein Hcp	NA	NA	NA	NA
WP_009935240.1\|1214718_1215267_+\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA
WP_004524812.1\|1215271_1217143_+\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_004537556.1\|1217139_1218585_+\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_004533146.1\|1218597_1221264_+	type VI secretion system ATPase TssH	K4FB40	Cronobacter_phage	5.2e-78	30.6
WP_004203275.1\|1221260_1223465_+	type VI secretion system tip protein VgrG	A0A077K8Q4	Ralstonia_phage	9.6e-46	29.9
WP_011857733.1\|1223480_1224191_+	hypothetical protein	NA	NA	NA	NA
WP_011857730.1\|1224150_1225410_+	DUF746 domain-containing protein	NA	NA	NA	NA
WP_004524822.1\|1226141_1226882_-	hypothetical protein	NA	NA	NA	NA
WP_004536893.1\|1228223_1229378_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_004557920.1\|1231150_1231789_+	hypothetical protein	NA	NA	NA	NA
WP_004524825.1\|1231831_1233076_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	7.1e-22	32.8
WP_004536997.1\|1233111_1234353_+	extracellular solute-binding protein	NA	NA	NA	NA
WP_004524828.1\|1234415_1235339_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_004524829.1\|1235339_1236191_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_004555376.1\|1236195_1238367_+	alpha-galactosidase	NA	NA	NA	NA
WP_014920210.1\|1238607_1240641_+	hypothetical protein	NA	NA	NA	NA
WP_004533334.1\|1241073_1241481_+\|transposase	transposase	A0A0P0ZCV4	Stx2-converting_phage	4.6e-10	34.9
WP_004524834.1\|1241477_1241825_+	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZBY2	Stx2-converting_phage	1.6e-40	72.9
WP_009935223.1\|1242936_1243383_+	hypothetical protein	NA	NA	NA	NA
WP_004533410.1\|1243799_1246004_+	type VI secretion system tip protein VgrG	A0A077K8Q4	Ralstonia_phage	4.9e-42	27.7
WP_004524859.1\|1246019_1247288_+	hypothetical protein	NA	NA	NA	NA
WP_004536961.1\|1247274_1251933_+	type IV secretion protein Rhs	A0A2H4JFP5	uncultured_Caudovirales_phage	8.3e-23	34.9
WP_004533385.1\|1252524_1252788_+	putative Immunity protein 75	NA	NA	NA	NA
WP_071811406.1\|1252788_1252986_+	hypothetical protein	NA	NA	NA	NA
WP_004536495.1\|1253137_1262563_+	hemagglutinin repeat-containing protein	NA	NA	NA	NA
WP_004533256.1\|1263005_1264766_+	ShlB/FhaC/HecB family hemolysin secretion/activation protein	NA	NA	NA	NA
WP_004533207.1\|1264984_1265359_+	DUF746 domain-containing protein	NA	NA	NA	NA
WP_101662898.1\|1265389_1266509_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	1.8e-48	39.1

DBSCAN-SWA_4

1970493 : 1999046

Acinetobacter_phage(33.33%)

plate,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_122780457.1\|1970493_1971006_-\|transposase	transposase	NA	NA	NA	NA
WP_009959103.1\|1971394_1971682_+\|transposase	transposase	NA	NA	NA	NA
WP_004551886.1\|1971766_1972210_+	CesT family type III secretion system chaperone	NA	NA	NA	NA
WP_162474617.1\|1972241_1973771_+	type III secretion system effector BopC	NA	NA	NA	NA
WP_004528803.1\|1974831_1975464_-	GTP cyclohydrolase I	A0A0P0HSD2	Acinetobacter_phage	9.9e-20	30.6
WP_004536825.1\|1975720_1975966_+	hypothetical protein	NA	NA	NA	NA
WP_160447233.1\|1975925_1977149_-	Ig-like domain-containing protein	NA	NA	NA	NA
WP_011857709.1\|1977873_1981878_-	type VI secretion system membrane subunit TssM-5	NA	NA	NA	NA
WP_004184888.1\|1981889_1982555_-	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_004536933.1\|1982551_1983949_-\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_004200965.1\|1983981_1984779_-	type VI secretion system lipoprotein TssJ	NA	NA	NA	NA
WP_004200966.1\|1984788_1985181_-	DUF4150 domain-containing protein	NA	NA	NA	NA
WP_004537525.1\|1985209_1985965_-	DUF3540 domain-containing protein	NA	NA	NA	NA
WP_004536499.1\|1985961_1987026_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_004537240.1\|1987043_1989677_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
WP_004533112.1\|1989702_1992726_-	type VI secretion system tip protein VgrG	A0A077K8Q4	Ralstonia_phage	4.6e-22	24.6
WP_004536540.1\|1992752_1995809_-	AAA family ATPase	A0A223W0B1	Agrobacterium_phage	3.5e-78	29.5
WP_004533373.1\|1995795_1996818_-\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_004200971.1\|1996805_1998548_-\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_004530572.1\|1998584_1999046_-\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP008758

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP008759

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection