CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP007648	Ligilactobacillus salivarius strain JCM1046 plasmid pMP1046B, complete sequence	0 crisprs	cas14k,cas14j,c2c9_V-U4	0	0	2	0
NZ_CP007649	Ligilactobacillus salivarius strain JCM1046 plasmid pLMP1046, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP007650	Ligilactobacillus salivarius strain JCM1046 plasmid pCTN1046, complete sequence	1 crisprs	NA	0	1	1	0
NZ_CP007646	Ligilactobacillus salivarius strain JCM1046 chromosome, complete genome	2 crisprs	cas14k,DEDDh,cas3,DinG,cas6,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,cas1,cas2,csm6,csa3,Cas14u_CAS-V	3	3	8	1
NZ_CP007647	Ligilactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence	1 crisprs	Cas14u_CAS-V,cas14j	1	1	3	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

44482 : 102139

Lactobacillus_phage(33.33%)

transposase,tail,integrase,holin

attL 64280:64299|attR 101567:101586

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044005825.1\|44482_45739_+\|transposase	transposase	A0A288TXV8	Enterococcus_phage	1.7e-55	36.9
WP_044005905.1\|47004_47721_+	deoxynucleoside kinase	A0A2K9VCW4	Lactobacillus_phage	3.4e-77	61.2
WP_044005826.1\|47729_47951_+	hypothetical protein	NA	NA	NA	NA
WP_052399089.1\|48086_48593_+	nucleoside 2-deoxyribosyltransferase	A0A2K9VD79	Lactobacillus_phage	2.6e-31	45.8
WP_044005827.1\|48711_48993_+	hypothetical protein	NA	NA	NA	NA
WP_044005828.1\|48997_49381_+	hypothetical protein	NA	NA	NA	NA
WP_044005829.1\|49681_50239_+\|integrase	tyrosine-type recombinase/integrase	D2XR58	Bacillus_phage	5.4e-30	43.6
WP_044005830.1\|50990_51329_+	hypothetical protein	NA	NA	NA	NA
WP_044005831.1\|51617_52283_-	thymidine kinase	A0A1W6JMX7	Lactococcus_phage	5.6e-50	54.8
WP_044005833.1\|52282_52627_-	hypothetical protein	NA	NA	NA	NA
WP_172399980.1\|52651_52795_-	hypothetical protein	A0A0A7NQQ0	Lactobacillus_phage	3.1e-06	57.8
WP_044005834.1\|52886_53195_-	hypothetical protein	NA	NA	NA	NA
WP_044005835.1\|53194_53713_-	hypothetical protein	NA	NA	NA	NA
WP_052399080.1\|54035_54590_-	MazG-like family protein	K4JW89	Streptococcus_phage	5.1e-20	35.3
WP_044005836.1\|54593_54998_-	hypothetical protein	NA	NA	NA	NA
WP_044005837.1\|54984_55653_-	N-6 DNA methylase	L0P368	Streptococcus_phage	3.0e-51	47.6
WP_052399081.1\|55872_56385_-	phosphatidylglycerophosphatase A	A0A2K9VCI2	Lactobacillus_phage	9.7e-34	43.2
WP_044005838.1\|56769_57054_-	hypothetical protein	NA	NA	NA	NA
WP_044005839.1\|57214_57712_-	hypothetical protein	NA	NA	NA	NA
WP_044005840.1\|57711_57993_-	hypothetical protein	K4I1W7	Lactobacillus_phage	7.5e-20	58.8
WP_044005841.1\|57994_58345_-	hypothetical protein	NA	NA	NA	NA
WP_044005842.1\|58346_58727_-	hypothetical protein	NA	NA	NA	NA
WP_044005843.1\|58740_59181_-	hypothetical protein	NA	NA	NA	NA
WP_148305462.1\|59180_59666_-	adenine-specific DNA methylase	A0A2H4IZ57	uncultured_Caudovirales_phage	5.7e-60	68.2
WP_148305463.1\|59703_59958_-	hypothetical protein	NA	NA	NA	NA
WP_044005846.1\|59950_60232_-	hypothetical protein	NA	NA	NA	NA
WP_044005847.1\|60228_60603_-	hypothetical protein	NA	NA	NA	NA
WP_052399082.1\|60832_61378_-	sugar-phospahte nucleotidyltransferase	A0MN47	Thermus_phage	2.0e-37	44.1
WP_044005850.1\|61579_62734_-\|transposase	transposase	C1KFS0	Lactobacillus_virus	1.5e-95	47.3
WP_080739404.1\|63544_64210_-	site-specific DNA-methyltransferase	A0A2P0ZL38	Lactobacillus_phage	1.1e-72	63.0
64280:64299	attL	NA	NA	NA	NA
WP_044005852.1\|64290_64647_-	hypothetical protein	NA	NA	NA	NA
WP_044005853.1\|64651_65305_-	hypothetical protein	NA	NA	NA	NA
WP_044005854.1\|65317_65854_-	hypothetical protein	NA	NA	NA	NA
WP_044005855.1\|65850_66372_-	hypothetical protein	NA	NA	NA	NA
WP_044005856.1\|66358_66895_-	hypothetical protein	NA	NA	NA	NA
WP_044005857.1\|66881_67409_-	hypothetical protein	NA	NA	NA	NA
WP_044005858.1\|67412_67889_-	DUF1064 domain-containing protein	A0A1I9KKZ1	Lactobacillus_phage	1.0e-32	46.8
WP_148305464.1\|69847_70315_-	hypothetical protein	NA	NA	NA	NA
WP_044005861.1\|70316_73658_-	DNA polymerase III subunit alpha	A0A218KC91	Bacillus_phage	2.5e-202	37.1
WP_044005862.1\|73647_74262_-	hypothetical protein	NA	NA	NA	NA
WP_158423237.1\|74285_75413_-	PD-(D/E)XK nuclease family protein	Q332G6	Clostridium_botulinum_C_phage	5.5e-29	28.4
WP_052399084.1\|75480_76557_-	hypothetical protein	Q332G7	Clostridium_botulinum_C_phage	1.6e-30	31.3
WP_044005865.1\|76664_77138_-	hypothetical protein	NA	NA	NA	NA
WP_191980120.1\|77223_78465_-	LysM peptidoglycan-binding domain-containing protein	A0A0S2MYF3	Enterococcus_phage	3.0e-89	47.9
WP_052399085.1\|78577_80941_-	hypothetical protein	A0A0A7NNI1	Lactobacillus_phage	1.3e-80	44.6
WP_044005866.1\|81038_81719_-	hypothetical protein	A0A0U4IPJ0	Arthrobacter_phage	4.6e-07	28.1
WP_044005867.1\|81731_83030_-	hypothetical protein	NA	NA	NA	NA
WP_044005868.1\|83079_83478_-	hypothetical protein	NA	NA	NA	NA
WP_044005869.1\|83485_84187_-	hypothetical protein	A0A0H3V0Q5	Geobacillus_virus	2.2e-28	32.8
WP_044005913.1\|84326_86465_-	hypothetical protein	NA	NA	NA	NA
WP_044005870.1\|86503_87523_-	hypothetical protein	NA	NA	NA	NA
WP_044005914.1\|87526_88654_-	hypothetical protein	NA	NA	NA	NA
WP_044005871.1\|88808_97553_-\|tail	phage tail tape measure protein	A0A0K2FL55	Brevibacillus_phage	1.0e-18	22.8
WP_044005872.1\|97491_98133_-	hypothetical protein	NA	NA	NA	NA
WP_191980121.1\|98225_98777_-	hypothetical protein	NA	NA	NA	NA
WP_044005874.1\|98900_99938_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_080739409.1\|100022_100235_-	type II toxin-antitoxin system RelB/DinJ family antitoxin	NA	NA	NA	NA
WP_044005875.1\|100307_100790_-	hypothetical protein	NA	NA	NA	NA
WP_044005876.1\|100805_101558_-	hypothetical protein	NA	NA	NA	NA
WP_044005877.1\|101698_102139_-\|holin	phage holin family protein	D9ZNF2	Clostridium_phage	1.5e-11	36.6
101567:101586	attR	NA	NA	NA	NA

DBSCAN-SWA_2

116028 : 124121

Bacillus_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044005888.1\|116028_117021_-	hypothetical protein	A0A218KCB5	Bacillus_phage	1.6e-40	32.1
WP_044005889.1\|117044_117491_-	hypothetical protein	NA	NA	NA	NA
WP_044005890.1\|117511_119110_-	hypothetical protein	A0A0K2FMA5	Brevibacillus_phage	2.7e-29	35.0
WP_044005891.1\|119131_120619_-	hypothetical protein	A0A2R2ZGH0	Clostridioides_phage	2.0e-34	27.9
WP_052399091.1\|120631_122068_-	hypothetical protein	A0A1P8CWR6	Bacillus_phage	5.2e-93	42.1
WP_044005892.1\|122441_122651_-	hypothetical protein	A0A0N9ST81	Staphylococcus_phage	7.0e-07	46.3
WP_044005893.1\|122634_123423_-	hypothetical protein	A0A0A8WEC3	Clostridium_phage	2.1e-11	26.1
WP_158423239.1\|123412_123559_-	hypothetical protein	NA	NA	NA	NA
WP_044005895.1\|123842_124121_-	HU family DNA-binding protein	A0A075E147	Dickeya_phage	1.2e-06	37.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP007650

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP007650_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP007650_1

30865-30943

Orphan

Consensus_repeat	Method
CCGGTTGGCAGGCAACGGAAAAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP007650_1

>merge|NZ_CP007650|1|30865-30943|CRISPRCasFinder
CCGGTTGGCAGGCAACGGAAAAACCTGTGATTTTATGATAATCATCTTAGATTATCCGGTTGGCAAGCAACGGAAAAAC

>NZ_CP007650|1|1|30865-30943|CRISPRCasFinder
CCGGTTGGCAGGCAACGGAAAAAC	CTGTGATTTTATGATAATCATCTTAGATTAT
CCGGTTGGCAAGCAACGGAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007650.1\|WP_044006038.1\|21792_22827_-\|replication-initiation-factor-domain-containing-protein	unknown	unknown	gnl\|CDD\|367101
NZ_CP007650.1\|WP_044006035.1\|19539_20862_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225962
NZ_CP007650.1\|WP_158423245.1\|21047_21623_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|212030
NZ_CP007650.1\|WP_003710985.1\|23626_24142_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007650.1\|WP_003711239.1\|32267_32570_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007650.1\|WP_044006034.1\|19115_19559_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225962
NZ_CP007650.1\|WP_044006033.1\|18834_19119_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007650.1\|WP_003711243.1\|28685_29894_-\|RepB-family-plasmid-replication-initiator-protein	unknown	unknown	gnl\|CDD\|376444
NZ_CP007650.1\|WP_155762323.1\|24157_24322_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007650.1\|WP_157664651.1\|27955_28099_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007650.1\|WP_003711240.1\|31523_32021_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225288
NZ_CP007650.1\|WP_003711238.1\|32583_33153_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP007650.1\|WP_044006037.1\|31003_31519_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376232
NZ_CP007650.1\|WP_003710983.1\|24367_24643_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP007650.1\|WP_044006038.1\|21792_22827_-\|replication-initiation-factor-domain-containing-protein	gnl\|CDD\|367101	pfam02486, Rep_trans, Replication initiation factor. Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family, including myelin transcription factor 2 and cerebrin-50.	1.64153e-38
NZ_CP007650.1\|WP_044006035.1\|19539_20862_+\|PH-domain-containing-protein	gnl\|CDD\|225962	COG3428, COG3428, Predicted membrane protein [Function unknown].	0.000429439
NZ_CP007650.1\|WP_003711243.1\|28685_29894_-\|RepB-family-plasmid-replication-initiator-protein	gnl\|CDD\|376444	pfam01051, Rep_3, Initiator Replication protein. This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.	1.43253e-44
NZ_CP007650.1\|WP_158423245.1\|21047_21623_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|212030	cd00118, LysM, Lysin Motif is a small domain involved in binding peptidoglycan. LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.	4.94582e-14
NZ_CP007650.1\|WP_003711238.1\|32583_33153_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	6.4742e-46
NZ_CP007650.1\|WP_003711240.1\|31523_32021_-\|hypothetical-protein	gnl\|CDD\|225288	COG2433, COG2433, Uncharacterized conserved protein [Function unknown].	0.000901216
NZ_CP007650.1\|WP_044006037.1\|31003_31519_-\|hypothetical-protein	gnl\|CDD\|376232	pfam18813, PBECR4, phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease4. A predicted endoRNase of the Barnase-EndoU-ColicinE5/D-RelE like nuclease fold found in polyvalent proteins of phages and conjugative elements. The predicted active site contains a conserved histidine residue.	8.1647e-15
NZ_CP007650.1\|WP_044006034.1\|19115_19559_+\|PH-domain-containing-protein	gnl\|CDD\|225962	COG3428, COG3428, Predicted membrane protein [Function unknown].	0.00022765

>NZ_CP007650.1|WP_003711243.1|28685_29894_-|RepB-family-plasmid-replication-initiator-protein
MDLQNKKVVQSNTLIKAIAKMDALPLKLFELAVANVDTKEKDPEVELEKDLIRTFLPRTNALRHDYLQTIMTNLMDKSTFTVKYTKENGKKKTEIFAPFSKIEFSEDESTVKLSFSNKIMPYITELKKNFTQYRIEDLRHFTSSNTITIYKVLMMYYNQYTNYIANGKRTKEELESFLNPVIDVSELKALTVQGKKSYDRFSDLKKRVIEPAIKEINEHTEFNITYDTIRVGRKIAKIQFHISNNSTEKLIGELTAEKKLSLSDVQNSPYTALLLGAMIVNFADANNESLMMSLGENVYPKYDVFVNKHSLDDLQKHLKYVKDHMNSKPNELDKYLIKALDDFEKNKGKYAKRDKSKLKQKEKLPDWAKDDTAQKNILTEKGIQRSKEIDELLEKINKDTSD
>NZ_CP007650.1|WP_157664651.1|27955_28099_+|hypothetical-protein
MKFVIILIIVPNKHVKRFAKLVALAVIRTGKIAIKKAIERLVSWLND
>NZ_CP007650.1|WP_003710983.1|24367_24643_-|hypothetical-protein
MKEQSDNDAKVGQLKKDIAELSDGFTPEYHIPSLPSEEVQRLKANFTRERYNQLLSELEQMKKEKKISFTDYSDIRFRLNQINGELKDQGK
>NZ_CP007650.1|WP_155762323.1|24157_24322_+|hypothetical-protein
MKYFWIKTFFGFLVVVALSVNYYLQSGHTWIFALAVIIELVEIPLLYYYEKKKH
>NZ_CP007650.1|WP_003710985.1|23626_24142_+|hypothetical-protein
MKVSTKFVSFVVAFLAFICVSFATTSVKADTYSTNKEVVVNTLLDNGYTYNQAITIASSMDISSTETLVGVDILPRTERSVAYTSSQILSKSDVRQIFNNINNVNLASSILGGIIGAKNPILGTVIGLGGFQNPNFKNAITQAYYQGKRVKIVYKSGASMSLNTVSYYVIN
>NZ_CP007650.1|WP_044006038.1|21792_22827_-|replication-initiation-factor-domain-containing-protein
MKQTLQTSIDWLEFTIFQLSYEDVIERILQLKIEDFADLSKGKFGYNAQTKWGNGNLFILFNQVDDEPCINHMGVHVILSGTGCRAYESQKSLYTLINVLVALENQAKLSRIDLAIDDFKDELIKFSRIRKAALRSEFTSRWNKWDELNSRSTGDGKLLGQTMYFGSQTSDIFCRIYDKALEQKRKVKDKDKEIPEKWTRLEIVYRKERAKMLALHMIECSNVGLVIRRTLQQYIRFVQRPKNSKDSNKSRWKTAKWWERLLENVEPLKLTIKKQDKTVDEMIKWLDKQIGPTLATVVTALDGEINWLYKLISNGNTRLKNKHQQAIFQYKQEKEKEHKGDENG
>NZ_CP007650.1|WP_158423245.1|21047_21623_-|LysM-peptidoglycan-binding-domain-containing-protein
MLYHFKHKADFKTKDEAIREAWHFGEYLHNMNLNDETALVLDVSSMMIDNDTIENIKAFHSVIMDFGYKRTGLQFRTENLQTNFDNCTYGNLWAINYYACNAGIDGVGTWRFTNDWHGLNVKMSYDFLGYYTEILGNQGIQLDLSNTYTVRPGDTLWLVAYQHGISVEELLKINGLTYDSTLRVGQKLQVA
>NZ_CP007650.1|WP_044006035.1|19539_20862_+|PH-domain-containing-protein
MKYRQSKKYFLLEFTSLLVASIWSYPFFKVLLLIFKNFKLALGILIIGYILSIFRIILGYFTTYFVVKDNNLYIHYGTIIIRTLHISTDNVSLIISNTRIENNFYHKLFNTKGLTIFFSGSEEEENEITFSAISPRVLNILLAFLSQNSIKKDQLYAQKSQIRDLTEKISFSTIFKTSILSSNYILIYLFLSDLLEFLNIHKSAKDYISNSLVVNLVSIVILMTLSILVQYFKYGNFTLKENDNEFIIKNGFIIRDINKIHKDNIKGIEIKSSLNMRFFKTINISAILSNENQGKSYSQNFLFPLTSLKNKNFIIQKHFPEISEDLLKNKNSIGIFRVILFLFSIIVLYMVLHTFNISWQLSLIVIYLSERHVSNILFTKVMIHGDFCKITKGFLNKKEYLLPINLIASKSQKIIGKIVVKSLTFNIQKGIKTTFINLEK
>NZ_CP007650.1|WP_044006034.1|19115_19559_+|PH-domain-containing-protein
MILTVNRKYIIYKNFLVFFGDLIIYLISSYLLYRFNFYNSYTISGFSIFAIVVFILEVISNYNYYKTAKVTITKETVHLDKGKFFKTSCSIPIKKVYIILEQQNIFMHIFGLKEVKFRTLARDISLEGVTETINLTKSDYLYEVQTI
>NZ_CP007650.1|WP_044006033.1|18834_19119_+|hypothetical-protein
MNQLLSNPLTYIIIGMIIQHAITPHIKWRYSIAVLPILVTIFGIYSALSHKISYIGVLGYFTIAIIFFLMAYTSKEELRKKKQDKLAKERFKSK
>NZ_CP007650.1|WP_044006037.1|31003_31519_-|hypothetical-protein
MAISKIDFDKLKKGFELYDNYFKNYEYTYLYRVGNEDKTLVVRFSKANFQHLTGLSYYRGPKKFYEDLADNRIDINNLNYDKNGFSRLKLSVIENLEMLIGDMARVSESGKFRHLSYDSLIRSNKAILAIACKGLKSFSIPISLLALRQEKIHITAYNVLEIKRQNLIQEN
>NZ_CP007650.1|WP_003711240.1|31523_32021_-|hypothetical-protein
MEYTRKKIAEEAQVSPQKVFRYIKAHNVEPTKRVGRTDYFSEDDAHEMLTFFAEEKKEREVNQTSSDDSISKDEYITTLKAQVQDLQKRLDSKEDEVSELHRLLSQEQQLARTEQSKRLELEATNTKLIEANTDVLNEKDTKIQELEKKLLEEKNKGFWSRLFGR
>NZ_CP007650.1|WP_003711239.1|32267_32570_-|hypothetical-protein
MTKLDKLMEDNQLTASPLFSNQGIMPELIDRAMKDSNLSYTSKGILLDLVRFNQSGATSNKFDPDILYAINNSKLDDKELIKNALSELEKGGYLTPLSSK
>NZ_CP007650.1|WP_003711238.1|32583_33153_-|recombinase-family-protein
MIFGYARVSTPQQSLDEQIEKLRRAGAEKIYYEKFTGRTNKRPEFQKLKKRLLPGDELIVTRLDRLGRKTSETTKFLDECFKRDITVNVLNMGRLDDSAGGKLMRNVVLAFAEFERDMIVTRTQEGKKYAKLHNKNYREGRPKRVITPKYRMIYEYKTSGHSYTETAKAFEISKSTIQRIVKQVESEEQ

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP007650_1	1.1\|30889\|31\|NZ_CP007650\|CRISPRCasFinder	30889-30919	31	NZ_CP007650	Lactobacillus salivarius strain JCM1046 plasmid pCTN1046, complete sequence	30889-30919	0	1.0
NZ_CP007650_1	1.1\|30889\|31\|NZ_CP007650\|CRISPRCasFinder	30889-30919	31	NZ_CP017110	Lactobacillus salivarius strain CICC23174 plasmid pLS_3, complete sequence	19081-19111	0	1.0
NZ_CP007650_1	1.1\|30889\|31\|NZ_CP007650\|CRISPRCasFinder	30889-30919	31	NZ_CP017473	Enterobacter cloacae strain M12X01451 plasmid pM12X01451, complete sequence	163103-163133	7	0.774
NZ_CP007650_1	1.1\|30889\|31\|NZ_CP007650\|CRISPRCasFinder	30889-30919	31	NC_014633	Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence	435689-435719	10	0.677

1. spacer 1.1|30889|31|NZ_CP007650|CRISPRCasFinder matches to NZ_CP007650 (Lactobacillus salivarius strain JCM1046 plasmid pCTN1046, complete sequence) position: , mismatch: 0, identity: 1.0

ctgtgattttatgataatcatcttagattat	CRISPR spacer
ctgtgattttatgataatcatcttagattat	Protospacer
*******************************

2. spacer 1.1|30889|31|NZ_CP007650|CRISPRCasFinder matches to NZ_CP017110 (Lactobacillus salivarius strain CICC23174 plasmid pLS_3, complete sequence) position: , mismatch: 0, identity: 1.0

ctgtgattttatgataatcatcttagattat	CRISPR spacer
ctgtgattttatgataatcatcttagattat	Protospacer
*******************************

3. spacer 1.1|30889|31|NZ_CP007650|CRISPRCasFinder matches to NZ_CP017473 (Enterobacter cloacae strain M12X01451 plasmid pM12X01451, complete sequence) position: , mismatch: 7, identity: 0.774

ctgtgattttatgataatcatcttagattat	CRISPR spacer
atgtgattttatcataatcatctttttgtaa	Protospacer
 *********** ***********    **

4. spacer 1.1|30889|31|NZ_CP007650|CRISPRCasFinder matches to NC_014633 (Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence) position: , mismatch: 10, identity: 0.677

ctgtgattttatgataatcatcttagattat	CRISPR spacer
aagtgattttatgaaaatcatcgtaagagga	Protospacer
  ************ ******* **..  .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

431 : 17209

Streptococcus_phage(100.0%)

integrase

attL 11487:11501|attR 18995:19009

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000813488.1\|431_1817_+	DNA translocase FtsK	A0A1S5SFB5	Streptococcus_phage	1.1e-265	100.0
WP_000879507.1\|1819_1972_+	hypothetical protein	NA	NA	NA	NA
WP_000398284.1\|1994_3200_+	replication initiation factor domain-containing protein	A0A1S5SEX3	Streptococcus_phage	2.8e-233	100.0
WP_001009056.1\|3242_3464_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000342539.1\|3580_4078_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_000506270.1\|4052_4559_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	8.6e-91	100.0
WP_000331160.1\|4542_6990_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	100.0
WP_000804748.1\|6992_9170_+	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	100.0
WP_000769868.1\|9166_10168_+	lysozyme family protein	A0A1S5SEZ8	Streptococcus_phage	5.0e-191	100.0
WP_001224318.1\|10164_11097_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	3.1e-171	99.4
WP_001791010.1\|11341_11458_+	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_002371500.1\|11473_13393_+	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	99.2
11487:11501	attL	NA	NA	NA	NA
WP_000336323.1\|13511_13679_+	cysteine-rich KTR domain-containing protein	D0R0F6	Streptococcus_phage	1.6e-14	68.0
WP_001227347.1\|13738_14092_-	helix-turn-helix domain-containing protein	A0A1S5SFA6	Streptococcus_phage	1.3e-58	100.0
WP_000804885.1\|14596_15019_+	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_000857133.1\|15015_15246_+	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000814511.1\|15706_15910_+	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_044006028.1\|15991_17209_+\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW7	Streptococcus_phage	8.3e-233	99.8
18995:19009	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP007646

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP007646_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP007646_1

810173-812140

TypeIII

Consensus_repeat	Method
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	PILER-CR
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CRISPRCasFinder
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CRT

26 spacers

cas2,cas1,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,csm6,DEDDh

The CRISPR arrays of NZ_CP007646_1

>merge|NZ_CP007646|1|810173-812140|PILER-CR,CRISPRCasFinder,CRT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAACTTTCTTTTCCATAATCTGTATAAGTCAACACTTCCTGTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACAACGGTACTAAAAAAGCATTTAGTTTTCCTGAAGTTGATAGTAAGAACATATCTCCGAATATAGGAGACGAAAACCCAATTCCTTCAACTCCATAAATTAAAATTTTCATTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACAGCTTCAATTTTGAAACATGTAATAATATTTAGTTTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACCTAGACTACCTAGTATTAAGTTGTCAAAGAGCGTACTTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACAACACTATTGAACACTCTAAAAGAGTCATCCATCTTATCAGTAAGAACATATCTCCGAATATAGGAGACGAAAACACCTTGGTGGTGTTGATGGTTTAGTTCACGTTTCTGAGTAAGAACATATCTCCGAATATAGGAGACGAAAACCTTCCAAAACTTTGATACGTTTACCTACTGCCTCAGTGATAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTTGAAACATAATTTAATATTAAGTTTTTTTAGAACATTTTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTTGAAGTAGATTAAATTATTAAGTTTTCATAGAACGTGTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACAAAACTTATCACTTAAATGTACTTTTTAAGTACATTTTTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACCTCAATTTTATTGACGTACTCAGTACCGCTTTTACAGTAAGAACATATCTCCGAATATAGGAGACGAAAACCCGAAGCGGGATATAACAATACATTTACACTCTTAAGAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTCATTGAAACTCTTAACAAACTTTTTCATAATTTTATAGTAAGAACATATCTCCGAATATAGGAGACGAAAACGCATAAGATTTTCTTGTCTATTTTTTTAACCCATTCTTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACCGGGGGATACTTCCAAACATATTTAAAAATTGACTAATTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTTCATTTATTGAACATCTTTATTTAATCATATGCTCTTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACACCAAATCTTCTTCTGTTAGTTCCCAAGCCTCTTTACCAGTAAGAACATATCTCCGAATATAGGAGACGAAAACGCTCCACTTGAAGCTTATCGCACTCAAGCCAAGCAATTTAGTAAGAACATATCTCCGAATATAGGAGACGAAAACGGTTCATCTACTTGTTTGAATGATTTTACCAATTTCAAGTAAGAACATATCTCCGAATATAGGAGACGAAAACACCCCATGAGGTTAGTTGCATAGTATTTATACCCCCACCCCCAGTAAGAACATATCTCCGAGTATAGGAGACGAAAACTCTATCTTCTGGCATAAAGATTTCATAACCTACCAGTAAGAACATATCTCCGAATATAGGAGACGAAAACATCAAGCTCATAATTGAAATTGTTGTAAAAATTAATGCCAGTAAGAACATATCTCCGAATATAGGAGACGAAAACTTCGTTCATTAGGTTTATCAATCTTTCATCAAATTTCATTTTAGTAAGAACATATCTTCGAATATAGGAGACGAAAACTTACCACCAGAAAAAGCAACTAAGATATTATCAAATTCATTAGTAAGAACATATCTCCGAATGTAGGAGACGAAAACCCTGCTGTTGTTAGTTCGATCATTTTTCTTCATCCTTTCGAGTAAGAACATATCTCCGAATATAGGAGCTTGAATC

>NZ_CP007646|1|1|810173-812064|PILER-CR
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTTCTTTTCCATAATCTGTATAAGTCAACACTTCCTGT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AACGGTACTAAAAAAGCATTTAGTTTTCCTGAAGTTGAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CCAATTCCTTCAACTCCATAAATTAAAATTTTCATT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AGCTTCAATTTTGAAACATGTAATAATATTTAGTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CTAGACTACCTAGTATTAAGTTGTCAAAGAGCGTACTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AACACTATTGAACACTCTAAAAGAGTCATCCATCTTATC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACCTTGGTGGTGTTGATGGTTTAGTTCACGTTTCTG
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CTTCCAAAACTTTGATACGTTTACCTACTGCCTCAGTGAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTGAAACATAATTTAATATTAAGTTTTTTTAGAACATTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTGAAGTAGATTAAATTATTAAGTTTTCATAGAACGTGT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AAAACTTATCACTTAAATGTACTTTTTAAGTACATTTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CTCAATTTTATTGACGTACTCAGTACCGCTTTTAC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CCGAAGCGGGATATAACAATACATTTACACTCTTAAG
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TCATTGAAACTCTTAACAAACTTTTTCATAATTTTAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GCATAAGATTTTCTTGTCTATTTTTTTAACCCATTCTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CGGGGGATACTTCCAAACATATTTAAAAATTGACTAATT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTCATTTATTGAACATCTTTATTTAATCATATGCTCTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACCAAATCTTCTTCTGTTAGTTCCCAAGCCTCTTTACC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GCTCCACTTGAAGCTTATCGCACTCAAGCCAAGCAATTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GGTTCATCTACTTGTTTGAATGATTTTACCAATTTCA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACCCCATGAGGTTAGTTGCATAGTATTTATACCCCCACCCCC
AGTAAGAACATATCTCCGAGTATAGGAGACGAAAAC	TCTATCTTCTGGCATAAAGATTTCATAACCTACC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ATCAAGCTCATAATTGAAATTGTTGTAAAAATTAATGCC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTCGTTCATTAGGTTTATCAATCTTTCATCAAATTTCATTTT
AGTAAGAACATATCTTCGAATATAGGAGACGAAAAC	TTACCACCAGAAAAAGCAACTAAGATATTATCAAATTCATT
AGTAAGAACATATCTCCGAATGTAGGAGACGAAAAC

>NZ_CP007646|1|1|810173-812140|CRISPRCasFinder
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTTCTTTTCCATAATCTGTATAAGTCAACACTTCCTGT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AACGGTACTAAAAAAGCATTTAGTTTTCCTGAAGTTGAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CCAATTCCTTCAACTCCATAAATTAAAATTTTCATT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AGCTTCAATTTTGAAACATGTAATAATATTTAGTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CTAGACTACCTAGTATTAAGTTGTCAAAGAGCGTACTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AACACTATTGAACACTCTAAAAGAGTCATCCATCTTATC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACCTTGGTGGTGTTGATGGTTTAGTTCACGTTTCTG
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CTTCCAAAACTTTGATACGTTTACCTACTGCCTCAGTGAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTGAAACATAATTTAATATTAAGTTTTTTTAGAACATTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTGAAGTAGATTAAATTATTAAGTTTTCATAGAACGTGT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AAAACTTATCACTTAAATGTACTTTTTAAGTACATTTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CTCAATTTTATTGACGTACTCAGTACCGCTTTTAC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CCGAAGCGGGATATAACAATACATTTACACTCTTAAG
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TCATTGAAACTCTTAACAAACTTTTTCATAATTTTAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GCATAAGATTTTCTTGTCTATTTTTTTAACCCATTCTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CGGGGGATACTTCCAAACATATTTAAAAATTGACTAATT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTCATTTATTGAACATCTTTATTTAATCATATGCTCTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACCAAATCTTCTTCTGTTAGTTCCCAAGCCTCTTTACC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GCTCCACTTGAAGCTTATCGCACTCAAGCCAAGCAATTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GGTTCATCTACTTGTTTGAATGATTTTACCAATTTCA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACCCCATGAGGTTAGTTGCATAGTATTTATACCCCCACCCCC
AGTAAGAACATATCTCCGAGTATAGGAGACGAAAAC	TCTATCTTCTGGCATAAAGATTTCATAACCTACC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ATCAAGCTCATAATTGAAATTGTTGTAAAAATTAATGCC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTCGTTCATTAGGTTTATCAATCTTTCATCAAATTTCATTTT
AGTAAGAACATATCTTCGAATATAGGAGACGAAAAC	TTACCACCAGAAAAAGCAACTAAGATATTATCAAATTCATT
AGTAAGAACATATCTCCGAATGTAGGAGACGAAAAC	CCTGCTGTTGTTAGTTCGATCATTTTTCTTCATCCTTTCG
AGTAAGAACATATCTCCGAATATAGGAGCTTGAATC

>NZ_CP007646|1|1|810173-812140|CRT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTTCTTTTCCATAATCTGTATAAGTCAACACTTCCTGT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AACGGTACTAAAAAAGCATTTAGTTTTCCTGAAGTTGAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CCAATTCCTTCAACTCCATAAATTAAAATTTTCATT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AGCTTCAATTTTGAAACATGTAATAATATTTAGTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CTAGACTACCTAGTATTAAGTTGTCAAAGAGCGTACTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AACACTATTGAACACTCTAAAAGAGTCATCCATCTTATC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACCTTGGTGGTGTTGATGGTTTAGTTCACGTTTCTG
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CTTCCAAAACTTTGATACGTTTACCTACTGCCTCAGTGAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTGAAACATAATTTAATATTAAGTTTTTTTAGAACATTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTGAAGTAGATTAAATTATTAAGTTTTCATAGAACGTGT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	AAAACTTATCACTTAAATGTACTTTTTAAGTACATTTTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CTCAATTTTATTGACGTACTCAGTACCGCTTTTAC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CCGAAGCGGGATATAACAATACATTTACACTCTTAAG
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TCATTGAAACTCTTAACAAACTTTTTCATAATTTTAT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GCATAAGATTTTCTTGTCTATTTTTTTAACCCATTCTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	CGGGGGATACTTCCAAACATATTTAAAAATTGACTAATT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTCATTTATTGAACATCTTTATTTAATCATATGCTCTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACCAAATCTTCTTCTGTTAGTTCCCAAGCCTCTTTACC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GCTCCACTTGAAGCTTATCGCACTCAAGCCAAGCAATTT
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	GGTTCATCTACTTGTTTGAATGATTTTACCAATTTCA
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ACCCCATGAGGTTAGTTGCATAGTATTTATACCCCCACCCCC
AGTAAGAACATATCTCCGAGTATAGGAGACGAAAAC	TCTATCTTCTGGCATAAAGATTTCATAACCTACC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	ATCAAGCTCATAATTGAAATTGTTGTAAAAATTAATGCC
AGTAAGAACATATCTCCGAATATAGGAGACGAAAAC	TTCGTTCATTAGGTTTATCAATCTTTCATCAAATTTCATTTT
AGTAAGAACATATCTTCGAATATAGGAGACGAAAAC	TTACCACCAGAAAAAGCAACTAAGATATTATCAAATTCATT
AGTAAGAACATATCTCCGAATGTAGGAGACGAAAAC	CCTGCTGTTGTTAGTTCGATCATTTTTCTTCATCCTTTCG
AGTAAGAACATATCTCCGAATATAGGAGCTTGAATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007646.1\|WP_051454391.1\|807787_808780_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl\|CDD\|187793
NZ_CP007646.1\|WP_049176028.1\|805739_806180_+\|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	gnl\|CDD\|367635
NZ_CP007646.1\|WP_158423223.1\|802691_803426_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
NZ_CP007646.1\|WP_034983394.1\|812221_813457_+\|CRISPR-associated-protein-Csm6	csm6	cd09699_csm6_CAS-III-A	gnl\|CDD\|187830
NZ_CP007646.1\|WP_014568359.1\|813611_814268_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP007646.1\|WP_034982461.1\|814283_814952_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP007646.1\|WP_052399049.1\|818979_819582_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007646.1\|WP_034983391.1\|806868_807771_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	csm4gr5	COG1567_csm4gr5_CAS-III-A	gnl\|CDD\|380071
NZ_CP007646.1\|WP_003704026.1\|809715_810021_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09638_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|273699
NZ_CP007646.1\|WP_034983389.1\|799628_801032_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CP007646.1\|WP_034983397.1\|803458_805738_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
NZ_CP007646.1\|WP_003702074.1\|806199_806865_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
NZ_CP007646.1\|WP_034982467.1\|820783_820981_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179979
NZ_CP007646.1\|WP_044004860.1\|798200_799511_+\|FADH(2)-oxidizing-methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))--methyltransferase-TrmFO	unknown	unknown	gnl\|CDD\|235416
NZ_CP007646.1\|WP_143455587.1\|822152_822764_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007646.1\|WP_051454353.1\|819633_820782_-\|NINE-protein	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
NZ_CP007646.1\|WP_044004868.1\|821596_822127_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|379617
NZ_CP007646.1\|WP_034982525.1\|820986_821550_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NZ_CP007646.1\|WP_044004866.1\|814944_817419_+\|ATP-dependent-RecD-like-DNA-helicase	unknown	unknown	gnl\|CDD\|273632
NZ_CP007646.1\|WP_044004863.1\|808804_809713_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694

Protein	Function_ID	Function_description	E-value
NZ_CP007646.1\|WP_051454391.1\|807787_808780_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl\|CDD\|187793	cd09662, Csm5_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	3.49222e-17
NZ_CP007646.1\|WP_049176028.1\|805739_806180_+\|type-III-A-CRISPR-associated-protein-Csm2	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	3.09541e-16
NZ_CP007646.1\|WP_158423223.1\|802691_803426_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	4.35624e-11
NZ_CP007646.1\|WP_034983394.1\|812221_813457_+\|CRISPR-associated-protein-Csm6	gnl\|CDD\|187830	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems.	1.5722e-49
NZ_CP007646.1\|WP_014568359.1\|813611_814268_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	3.46717e-67
NZ_CP007646.1\|WP_034982461.1\|814283_814952_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	4.89269e-09
NZ_CP007646.1\|WP_034983391.1\|806868_807771_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm4	gnl\|CDD\|380071	pfam17953, Csm4_C, CRISPR Csm4 C-terminal domain. Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci play a pivotal role in the prokaryotic host defense system against invading genetic materials. The CRISPR loci are transcribed to produce CRISPR RNAs (crRNAs), which form interference complexes with CRISPR-associated (Cas) proteins to target the invading nucleic acid for degradation. The interference complex of the type III-A CRISPR-Cas system is composed of five Cas proteins (Csm1-Csm5) and a crRNA, and targets invading DNA. This entry represents the C-terminal domain found in Csm4. Csm4 structurally resembles Cmr3, a component of the type III-B CRISPR-Cas interference complex. Studies indicate that Csm3-Csm4 complex binds single-stranded RNA in a non-sequence-specific manner. Structural analysis show, Csm3 and Csm4 have one and two ferredoxin-like folds (also known as an RRM-like fold), respectively. The long beta-hairpin inserted into the C-terminal ferredoxin-like fold of Csm4, is well-conserved in the Cmr3 structure. The corresponding beta-hairpin of Cmr3 binds the D1 domain of Cmr2, as observed in the Cmr2-Cmr3 complex structure. Furthermore, it is suggested that the hairpin of Csm4 is responsible for the interaction with Csm1 (ortholog of Cmr2).	2.24935e-30
NZ_CP007646.1\|WP_003704026.1\|809715_810021_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|273699	TIGR01573, cas2, CRISPR-associated endonuclease Cas2. This model describes most members of the family of Cas2, one of the first four protein families found to mark prokaryotic genomes that contain multiple CRISPR elements. CRISPR systems protect against invasive nucleic acid sequences, including phage. Cas2 proteins have been characterized as either endoribonuclease (for ssRNA) or endodeoxyribonuclease (for dsDNA), depending on the system to which the Cas2 belongs. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats. The cas genes usually are found near the repeats. A distinct branch of the Cas2 family shows a very low level of sequence identity and is modeled by TIGR01873 instead of by this model (TIGR01573).	1.56102e-16
NZ_CP007646.1\|WP_034983389.1\|799628_801032_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	4.42117e-70
NZ_CP007646.1\|WP_034983397.1\|803458_805738_+\|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	0
NZ_CP007646.1\|WP_003702074.1\|806199_806865_+\|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	2.31534e-86
NZ_CP007646.1\|WP_034982467.1\|820783_820981_-\|hypothetical-protein	gnl\|CDD\|179979	PRK05257, PRK05257, malate:quinone oxidoreductase; Validated.	0.00929885
NZ_CP007646.1\|WP_044004860.1\|798200_799511_+\|FADH(2)-oxidizing-methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))--methyltransferase-TrmFO	gnl\|CDD\|235416	PRK05335, PRK05335, tRNA (uracil-5-)-methyltransferase Gid; Reviewed.	0
NZ_CP007646.1\|WP_051454353.1\|819633_820782_-\|NINE-protein	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	8.34993e-38
NZ_CP007646.1\|WP_044004868.1\|821596_822127_-\|PH-domain-containing-protein	gnl\|CDD\|379617	pfam14470, bPH_3, Bacterial PH domain. Proteins in this family are distantly related to PH domains.	5.48384e-17
NZ_CP007646.1\|WP_034982525.1\|820986_821550_-\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	1.04479e-05
NZ_CP007646.1\|WP_044004866.1\|814944_817419_+\|ATP-dependent-RecD-like-DNA-helicase	gnl\|CDD\|273632	TIGR01448, recD_rel, helicase, putative, RecD/TraA family. This model describes a family similar to RecD, the exodeoxyribonuclease V alpha chain of TIGR01447. Members of this family, however, are not found in a context of RecB and RecC and are longer by about 200 amino acids at the amino end. Chlamydia muridarum has both a member of this family and a RecD. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP007646.1\|WP_044004863.1\|808804_809713_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	1.69843e-87

>NZ_CP007646.1|WP_003704026.1|809715_810021_+|CRISPR-associated-endonuclease-Cas2
MMLLVCFDLPRDTKENRKEATKYHKKLVELGFTMKQFSVYEREVRQNSTRDRVIKVLKDRLPKSGAITLYLLPNEVNDSQITILGSESIKKTVRKPQFIVL
>NZ_CP007646.1|WP_044004863.1|808804_809713_+|type-II-CRISPR-associated-endonuclease-Cas1
MRDIIYIENKHFVGITKDSFKLKNVVDETERYFPFDEVDYLIFDSHSSFISERVITTCVENNIGLIFCDKTHTPQLLMTSIYGQNERFKRQSKQLAMSKKTKGRIWQKIIKTKINNQADCLKYIVKNDEVSDIVRSIGKTVTEGDKNNHEAYAARVYFSNLFGKSFKRGRYDDIINSSLNYGYAILRSAIRKELVIYGLEPSWGIHHVSTENPFNLSDDIIEVYRPFLDALVVELLNNNESEELDIELKKEIIKVLFEKCVVDNKVYSLLDAIKVTIKSFVSCVDKNSATGLKLPTFIEEGR
>NZ_CP007646.1|WP_051454391.1|807787_808780_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MLKRQDYEFVLYTLAPVHIGSGVKVTSKESIQENGEYYFPEMDKLYLFLEKNHPESLPAFEQYLLDSGSKTNKRKSRLIDFLNDQKIKERDFGGFKIKQNNLVERLNEVSLFARDGLGRRYIPGSSLKGAIRTILESEYFRGKQISWGAKSGQQFDDIFNNIRVGDSNTIGESNFSIVQKWDYARNKDPKPMPIYRESLQPLKKITFNISAVGEEAISLIDNLENIAEKHYLYYRKFFLDNNFDKKYIQNNIKAPIYLGAGSGIWTKTNIRQMDDEKINAIRRKQYVKMRMKDKGVMKLTKYPTNVNSKIVKTKNFYEIGKCNFEVKKKS
>NZ_CP007646.1|WP_034983391.1|806868_807771_+|type-III-A-CRISPR-associated-RAMP-protein-Csm4
MEVQAYKLDFQTVHFGNGNLNESIGSFNASRLYSALFLESLKLNVDKEFLDLSKSDNFFLSDSFPLKDGEFYLPKPIGYPKMPLISESTKEMQRNAKKSKKLQYIKYTDIEDYVKGNCDIGKLEGISSFFSKSTVVTKKGIDPYEVGITNFKTSLYILTIKHELLDMLMNSLQYSGIGGKRSSGYGRFTIEKLDIPNEFSKNIVINDSEYGVYMTLNTSIPNNDELDVVLPTAEYLLEKSSGFAYSTASKSLLRKQDLYKFVVGSTLTKTYSGNIFDVRPDGFPHPVWNYAKGLFYKLPY
>NZ_CP007646.1|WP_003702074.1|806199_806865_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MLNKLKIEGTIKVESGLHIGGSTEFAAIGAIDSPVIKDSLTNLPIIPGSSLKGKMRTLLAKAYNDAPLVSGTSANNDDYRIKRLFGATTQNADGQLIIGRLIFRDSILSNREELAQLGAKSYTETKFENTIDRFTAVATPRQIERVIRGSKFDFELIYDVEKESEVEEDIQLVKTGLELLENDYLGGSGSRGYGKVKFENLSIKPVLGNYDVKGLDAILEG
>NZ_CP007646.1|WP_049176028.1|805739_806180_+|type-III-A-CRISPR-associated-protein-Csm2
MYNKRKPQGNYDKIVNQKFSLKFTDESYVNEAKDVIEIFKEENFKVNRDTLTNTQLRNLLAMTSAVYDEARNNGFDSVNEKIAYLKVQFIYQSGRNTAVKAFIEVAQLVELVDMIRDFKELDDLLRFCHYMEALIAYFKYYGGSDK
>NZ_CP007646.1|WP_034983397.1|803458_805738_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MNSLFYGSALHDVGKIVQRSTNERITHSRIGVNYLKKFTDNIDILHQVNYHHVKEINGAKLENDDLAFITYIADNIASGTDRRKIETDTKRQWDSKTNLEDIFDRFGENSTRRYIVPSMLSEDTSKIFPVKDKVEFNSSEYTKIVTRITNTLSVINFAPDYQQSVLNLIEATASFIPSSTNVQESVDVSLYDHMRLTAGIACAIYLYLEEKQEYNYKNTLYNNSQNFYRQNAFKLVSFDISGIQKFLYTITTSGAHKQLRSRSFYLDMISETIVDSLLSKLDLSRANVIYSGGGRAYLVLPNTKSADKAIKEVEKEFNQFFIDKFNIQLYVSFGSSIFTANDLMDKKDNEKIYNSIFREVSHQISERKLSRYDVSTIKQLNMGGKKVGRECIICHSVDNLVEGENKCQLCFSLENFSSDLQKEKYFVVDDEVSGLQIGPNMYIHKVSEEDIKSGKVNGKIYTKNEFVTGADQSIRLMMGDYSYLHNNEFGKYSDRDWTKVDSSSSPVGIKRIAALRCDVDDLGYGFIGGFKEQDSGKYNTFSRIATFSRRMSIFFKTYINSFAKDKRLTIVYSGGDDVFILGAWDEVIEFAIDLRQKFISWTDGKLTLSAGIGMFDSKTPINVIARETGTLEDAAKDNDKNSIALFDIKYTFNFDYFIDNVYNSKLSYIKEFFENQPEQGKTFIYRLLDLIYNRDTKDRISFARIAYTLAKAEESIPKEKRKEFIDFKSKMLNWFEDEKEILSTELALMLYIYQIRKDR
>NZ_CP007646.1|WP_158423223.1|802691_803426_+|CRISPR-associated-endoribonuclease-Cas6
MKKVTFICNKKQKFSYHLGPQFHGWLMENISEEAADYLHESKINCYSISVSNDDKNVYFTINLLNEVAEKIFSYLVLDKEIDKIVLNNSIQKEFLVLNKQIEELTAKQLTRNFYEGISSREVVVDIMSPISFKVQGDYYFFPDLELMFRNLMQKYNATFENTNIVDNDLLQEILENSKIVSYKVQSSYYPIHKAFVPGTIGRIKIRFKGNQTLTNYTQMLLNFGVFSGIGVKTGMGMGHISIAK
>NZ_CP007646.1|WP_034983389.1|799628_801032_+|PTS-galactitol-transporter-subunit-IIC
MLETLNNFFTIFGASIIVPIIIFIIALFLHVKFSKAIMSAFYAGVGLTGFNWVIAEFTPIVTKIVRQMVNNTGIKLPVVDIGWQAGSLASFGSSVGITFFVFGLIFELIIFALGITKVFMASNLWNNFGFMIWGTLAYYVTHNFWLSLSLSFFMLLYTLVIAEIQADRWSEYFEIKNATVASLHNIEQTIPAILLDPLWNLLGFNKVKLTPKVFKDRLGVFGEPTSLGVILGIIIGILGNLNNLTDIDAWGEILKFAIQLAAVMTIFPLITDVFAKAFIPLADAIDSRQKEEMKEKTHPKRWFLGIDDGVGYGEPATIISGMILIPIMVLLAFVLPGNRTLPVVDLIALPFMVESIVAITRGNILKIIANGIIWFSLGLYASSWLGSVYTEAVSNYGATIPTGIVLITSFNLMARPLNAVVFAAFISQNPFWIGLCLVTYLVLLFLLRRYRSQIWSYLRKMSEKNIN
>NZ_CP007646.1|WP_044004860.1|798200_799511_+|FADH(2)-oxidizing-methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))--methyltransferase-TrmFO
MTASVNVIGAGLAGSEAAWQIANQGVKVRLYEMRPQKLTPAHHTENFAELVCTNSLRANRLTNAAGLLKEEMRTFNSIIMESADKHSVPAGGALAVDRETFSKEVTEKLHNHPNVGIINEEIDEIPEGLTVIATGPLTSDALAKDITKFTGSDGLFFFDAAAPILEKSSLDMDKVYLKSRYDKGEAAYLNAPMTKDEFYNFYNELIKAETAELHDFEDDKFFEGCMPIEEIASRGAQTMLYGPLKPVGLEDPRTGKEPFAVVQLRQDNAAGDLYNIVGFQTHLKWSEQKRVFSMIPGLENARFVRYGVMHRNTFLCSPEVMQATYQTKKRPDLFFAGQMTGVEGYVESAASGLYAGLNAARIAQGKDPVIFPEETMMGAMAHYITHASVKNFQPINANFGIVPKLQERIRNKQERNLKISERAIDRIKKFKNLNFD
>NZ_CP007646.1|WP_034983394.1|812221_813457_+|CRISPR-associated-protein-Csm6
MTTLISCIGDTDPIRNRHDGALLHLARVFRPEKILLIYSERALLKENNILLALNSIEGYNPVIKKDERFISNSEVFIFDKMYEILNNIVLKYSRDDEDLILNLSSGTPQMKSALFTINRLNDINVRAYQVITPSHSSNEGIGHDNNLGINYLISTNLDNRKDFKKRILEDKAEKFQKTLIKRTMKDLLNNFDYESLYNLSIRHRVLSKSKMKKVISSLQDLTEAVKYQKLLKVVSQTKYSEKEKKLINSYLIILLQANRELVSEVLIRSKNIGEYACELYLEKNYPDLILWDKGRPYLNSINYPDIEDKLLNNEDIHYRKEQYLNIHFYIQILKELNENKELIENLLKLSGYNQQRNKVAHGLSEIPSSQVKVQKIVNLCYQVIGKCIDLKEDWSKFYDQFNNDISTILDE
>NZ_CP007646.1|WP_014568359.1|813611_814268_+|histidine-phosphatase-family-protein
MTRFFFVRHGKTEWNLEGRYQGAHGDSPLLPQSLEEIKQLSEYLKTYRFAKIYSSPIKRALVTAQKIKENLPYNVRLEADAAFSEFNLGKMEGMKFTEVAEKYPAELDAFRNHPDKYDPTTIEGESFPELFARMTPKIRDIVKRYPNDDILIVSHGAALCAEIRYLQGIPLEKIRAKGGLANTSTTILQTVDDNQKFKCLVWNKTDYLKRDLDATDVV
>NZ_CP007646.1|WP_034982461.1|814283_814952_+|tetratricopeptide-repeat-protein
MDKNIKNKAEELIKDLIQKIDNNPYDAQAYYNLGVALNDAHSAEQAEELFKKALNIFANSKEKSSLMHYGLGNVYYTNSMYDKAIVEFKKVQSEKLKQDSMLMMAQAYYAQENYPQAMIYALTVSENTKHNVDAISLLASCFMATGDLTNARKYYLKALEYDKDNVEVLFQLGVIELSLSGEAGKYFDRVKNLDNEYYKKMQQRLADVQRFLMTQKKGKSDE
>NZ_CP007646.1|WP_044004866.1|814944_817419_+|ATP-dependent-RecD-like-DNA-helicase
MSEELDLFAQEDNGKYLIGTVNAVYFEASDSFYKVLQVLIKETNFDWDDQRITVTGSFANIQTDSLYRFEGNVVEHQRYGKQFQSESYQLELPSTKDGVIAYLSSDEFVGIGKKTAEKIVKKLGVDAIDALNNDMDKLEELGLSEKQKDSIKKVLKENYGIDKIIIELNSLGFTSTMAGRIYNNYTNSTLEIIHEDPYRLSVDIDGISFTKADQIAQQFGFASDSPGRIRGAIFQSLYDLTYATGNTYVELKPLVTETLKLLESNRNEAIDPQLVADQLIKLAEEDKIKSDDNKVYSRTFFNAEWNIAENLYRLLKSGNSDLPNNDALLDKLLIKAEDQLGIDYDSEQKRAIKDAIKSPVFLLTGGPGTGKTTIINGIVAVYALLNDIDLDIGKYDKDNPFPILLAAPTGRAAKRMAESTGLPASTIHRMLGINAHDDKLPEDIQELEGALLIVDETSMVDTLIMDLLLNSIPSHMQVIFVGDRNQLPSVQPGQVFSDLLVSDTLPKKELTKIYRQGEGSSIINLAHSIKNGELPADFTKAQSDRAFIPCEAGQLTSAVEQVVKAALNKGNSKEDIQVLAPMYRGNAGINRLNTILQELLNPAKPRQKEVIFNEQVFRIGDRVLHLVNDPENNVFNGDIGKIVGINIPKTKKDKKGEQIIVDFDGNEVTFDKKDWINLTLAYCMSIHKSQGSEFPIVVLAMLPQYQRMFARNLLYTGITRAKQKLVLLGNVSSFRQSAEIISLNRKTGLLKRIRMEFGVEGKPVEKTDNEEVAVNNNKEQDSIVEEQDEPFIYNDGILTMDIIVNNKVDAMIGMDDITPYDFMG
>NZ_CP007646.1|WP_052399049.1|818979_819582_-|hypothetical-protein
MESVIPKILGIFISLGIAYLIFKWNKKNKQSKIYYTIACMFLIGGLYMPFAKTVSPEQEAAESSKAESSSTSEVSKNVQKHSEKSSENSDNTNTRNELDTAVNFINNKSNSMKASIAEDNKAIILTVDDSVSNVALNANKSEENQDNWIKFTGEINNLTKNMLVGKYNVKVPFIVESTDGTKLMESKHGFTVYDIMDHEQ
>NZ_CP007646.1|WP_051454353.1|819633_820782_-|NINE-protein
MKKIKDLIEKNFIKSKNIWLAYLLAIFLGTFGLHRFYLKKNGLKMLLITVLTLGVGVIITYPMLILDLIRIPSWVEECNENNLTPPTEKNIQTNKSSKHINNTVTSTSLNESMSISTSLNESLSESLSTSNSLSDSLSASTFLSDSLSSSTSLNNSLSTNIEETNSSNIDKPRNSQVISYDFKPKLQPVMEFEPKTKTKKKSTRTKTNSSETIKISRLRKLRDDYVVVDIETTGLSPGEDKIIQLSAIKYIDNKEIAVFNEYINPHTKLSDFIINLTGISQDVVDHGKELNDIKDDFISFYGDLPLVGHYINGFDIKFLIANNLVIKNVATIDTLPLARKLDLENAKLPTVKKFLGINNNSHDSLDDCYTTNALYQFAKENF
>NZ_CP007646.1|WP_034982467.1|820783_820981_-|hypothetical-protein
MRGYIRKPSLKKSFKAATTAKYKRRLKKKLIPGYGTRTAGWLHPKRKLYNKVYHRTSKSLWDLFK
>NZ_CP007646.1|WP_034982525.1|820986_821550_-|hypothetical-protein
MKFITTTLLFMSLLGACSNSNSSSKTSSESYKSSSLKAKKAKESSKKKAESIKKAKEESKRKAESKKKASESKRKESESKASSESASIAESQSRASESESIAKAGSESLASAQENQSSDTNYDNNGNNSNFQNTDMNTADTGKIVGNVNSHIYHVPGQHGYNMNSANAVYFNSEQDAINAGYRKALR
>NZ_CP007646.1|WP_044004868.1|821596_822127_-|PH-domain-containing-protein
MDLETIIKQLEKANVTDTFGTKKEIKALPEIINDDETILYATSGFFKGNTVLIVCTDNRILFIDKGLIYGVKSYEIPLDMVNGVSYSIGLVFGKVSVVNGAITNEIDNIEKKTVSILADTIKKAANNYKNKLKQSTISTNANINTTDPDSITQLLNVNSEILHELRAIRHLLEKDS
>NZ_CP007646.1|WP_143455587.1|822152_822764_-|hypothetical-protein
MKKFNVITISLLSLSLLGACSNSNSNDKSSSSSIKSEKKATSSKAASSSISPTSSKEELKAAISTPMTKENYQNLEDELLEAANVDDIHDHSATMQGKLNKFNVRANNILKQKISKKDLHKEKKFLTSSDYQKFKEYSNNLDDYLSALYDYAVKYQSNTPVINDDKTSQSTKDDYQKELDQFKSKFDNAKEKWSSSYDSIMNS

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Crispr_ID: NZ_CP007646_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP007646_2

1762360-1762460

TypeI-A

Consensus_repeat	Method
ACCAACAACTCGGGTAGTGATAA	CRISPRCasFinder

1 spacers

Cas14u_CAS-V

The CRISPR arrays of NZ_CP007646_2

>merge|NZ_CP007646|2|1762360-1762460|CRISPRCasFinder
ACTAACAATTCTGACAGTAATAACAGTAATATCCCTACTGATAATGGTAATGTAGATACTGGAAACAGTGATAATAATGCCAACAACTCAGGTAGTGACAA

>NZ_CP007646|2|2|1762360-1762460|CRISPRCasFinder
ACTAACAATTCTGACAGTAATAA	CAGTAATATCCCTACTGATAATGGTAATGTAGATACTGGAAACAGTGATAATAAT
GCCAACAACTCAGGTAGTGACAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007646.1\|WP_044005525.1\|1774261_1775482_-\|transposase	Cas14u_CAS-V	-	gnl\|CDD\|223747
NZ_CP007646.1\|WP_034982402.1\|1769705_1770470_-\|iron-export-ABC-transporter-permease-subunit-FetB	unknown	unknown	gnl\|CDD\|377092
NZ_CP007646.1\|WP_044005523.1\|1772760_1773255_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239312
NZ_CP007646.1\|WP_044005515.1\|1760795_1761353_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP007646.1\|WP_034982411.1\|1759769_1760291_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP007646.1\|WP_003700992.1\|1758928_1759429_+\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|377783
NZ_CP007646.1\|WP_044005513.1\|1754406_1756308_+\|peptidase-M13	unknown	unknown	gnl\|CDD\|226118
NZ_CP007646.1\|WP_044005518.1\|1766245_1766725_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319968
NZ_CP007646.1\|WP_034982418.1\|1752749_1753364_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP007646.1\|WP_003700975.1\|1771252_1772479_-\|OFA-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340911
NZ_CP007646.1\|WP_034982409.1\|1761626_1761833_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182727
NZ_CP007646.1\|WP_003700998.1\|1753718_1754276_+\|energy-coupled-thiamine-transporter-ThiT	unknown	unknown	gnl\|CDD\|370542
NZ_CP007646.1\|WP_044005522.1\|1770450_1771104_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|182331
NZ_CP007646.1\|WP_044005521.1\|1769274_1769592_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|334619
NZ_CP007646.1\|WP_044005520.1\|1767869_1769159_+\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|376574
NZ_CP007646.1\|WP_003709363.1\|1773314_1773839_-\|DUF308-domain-containing-protein	unknown	unknown	gnl\|CDD\|225786
NZ_CP007646.1\|WP_044005519.1\|1766753_1767593_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381383
NZ_CP007646.1\|WP_003700996.1\|1756436_1757282_+\|D-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|238799
NZ_CP007646.1\|WP_034982413.1\|1758093_1758939_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180840
NZ_CP007646.1\|WP_044005514.1\|1757320_1757914_-\|SdpI-family-protein	unknown	unknown	gnl\|CDD\|227945

Protein	Function_ID	Function_description	E-value
NZ_CP007646.1\|WP_044005525.1\|1774261_1775482_-\|transposase	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	3.58048e-18
NZ_CP007646.1\|WP_034982402.1\|1769705_1770470_-\|iron-export-ABC-transporter-permease-subunit-FetB	gnl\|CDD\|377092	pfam03649, UPF0014, Uncharacterized protein family (UPF0014).	2.76696e-89
NZ_CP007646.1\|WP_044005523.1\|1772760_1773255_+\|peroxiredoxin	gnl\|CDD\|239312	cd03014, PRX_Atyp2cys, Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a bacterial periplasmic peroxidase which differs from other PRXs in that it shows substrate specificity toward alkyl hydroperoxides over hydrogen peroxide. As with all other PRXs, the peroxidatic cysteine (N-terminal) of Tpx is oxidized into a sulfenic acid intermediate upon reaction with peroxides. Tpx is able to resolve this intermediate by forming an intramolecular disulfide bond with a conserved C-terminal cysteine (the resolving cysteine), which can then be reduced by thioredoxin. This differs from the typical 2-cys PRX which resolves the oxidized cysteine by forming an intermolecular disulfide bond with the resolving cysteine from the other subunit of the homodimer. Atypical 2-cys PRX homodimers have a loop-based interface (A-type for alternate), in contrast with the B-type interface of typical 2-cys and 1-cys PRXs.	2.58753e-56
NZ_CP007646.1\|WP_044005515.1\|1760795_1761353_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.35232e-11
NZ_CP007646.1\|WP_034982411.1\|1759769_1760291_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.17123e-07
NZ_CP007646.1\|WP_003700992.1\|1758928_1759429_+\|ECF-transporter-S-component	gnl\|CDD\|377783	pfam07155, ECF-ribofla_trS, ECF-type riboflavin transporter, S component. This family is the substrate-binding component (S component) of the energy coupling-factor (ECF)-type riboflavin transporter. It is a transmembrane protein which binds riboflavin, and is responsible for riboflavin-uptake by cells.	6.29669e-33
NZ_CP007646.1\|WP_044005513.1\|1754406_1756308_+\|peptidase-M13	gnl\|CDD\|226118	COG3590, PepO, Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP007646.1\|WP_044005518.1\|1766245_1766725_-\|VOC-family-protein	gnl\|CDD\|319968	cd16361, VOC_ShValD_like, vicinal oxygen chelate (VOC) family protein similar to Streptomyces hygroscopicus ValD protein. This subfamily of vicinal oxygen chelate (VOC) family protein includes Streptomyces hygroscopicus ValD protein and similar proteins. ValD protein functions in validamycin biosynthetic pathway. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	9.00241e-19
NZ_CP007646.1\|WP_034982418.1\|1752749_1753364_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.17923e-05
NZ_CP007646.1\|WP_003700975.1\|1771252_1772479_-\|OFA-family-MFS-transporter	gnl\|CDD\|340911	cd17353, MFS_OFA_like, Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.32447e-116
NZ_CP007646.1\|WP_034982409.1\|1761626_1761833_+\|hypothetical-protein	gnl\|CDD\|182727	PRK10783, mltD, membrane-bound lytic murein transglycosylase D; Provisional.	0.00167171
NZ_CP007646.1\|WP_003700998.1\|1753718_1754276_+\|energy-coupled-thiamine-transporter-ThiT	gnl\|CDD\|370542	pfam09515, Thia_YuaJ, Thiamine transporter protein (Thia_YuaJ). Members of this protein family have been assigned as thiamine transporters by a phylogenetic analysis of families of genes regulated by the THI element, a broadly conserved RNA secondary structure element through which thiamine pyrophosphate (TPP) levels can regulate transcription of many genes related to thiamine transport, salvage, and de novo biosynthesis. Species with this protein always lack the ThiBPQ ABC transporter. In some species (e.g. Streptococcus mutans and Streptococcus pyogenes), yuaJ is the only THI-regulated gene. Evidence from Bacillus cereus indicates thiamine uptake is coupled to proton translocation.	3.86715e-63
NZ_CP007646.1\|WP_044005522.1\|1770450_1771104_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|182331	PRK10247, PRK10247, putative ABC transporter ATP-binding protein YbbL; Provisional.	5.9123e-83
NZ_CP007646.1\|WP_044005521.1\|1769274_1769592_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|334619	pfam01638, HxlR, HxlR-like helix-turn-helix. HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.	1.69039e-39
NZ_CP007646.1\|WP_044005520.1\|1767869_1769159_+\|ISL3-family-transposase	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	3.05431e-69
NZ_CP007646.1\|WP_003709363.1\|1773314_1773839_-\|DUF308-domain-containing-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	7.66331e-13
NZ_CP007646.1\|WP_044005519.1\|1766753_1767593_-\|aldo/keto-reductase	gnl\|CDD\|381383	cd19157, AKR_AKR5G1-3, AKR5G family of aldo-keto reductase (AKR). Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.	2.8605e-148
NZ_CP007646.1\|WP_003700996.1\|1756436_1757282_+\|D-amino-acid-aminotransferase	gnl\|CDD\|238799	cd01558, D-AAT_like, D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.	1.6323e-96
NZ_CP007646.1\|WP_034982413.1\|1758093_1758939_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180840	PRK07105, PRK07105, pyridoxamine kinase; Validated.	3.13518e-58
NZ_CP007646.1\|WP_044005514.1\|1757320_1757914_-\|SdpI-family-protein	gnl\|CDD\|227945	COG5658, COG5658, Predicted integral membrane protein [Function unknown].	1.87795e-10

>NZ_CP007646.1|WP_034982409.1|1761626_1761833_+|hypothetical-protein
MTILLFGLGVIALSNVEVQASSWHANSPAEIAKRISSNDRTFTFERGDTFWGISQVLNINYQTLMEWI
>NZ_CP007646.1|WP_044005515.1|1760795_1761353_+|TetR/AcrR-family-transcriptional-regulator
MGNIRKTDSKKRILKAFIEILNTDGFNKMTVSKITSLAHINRGTFYLNYIDKFDLLEEIEQEIFTKIKTILLEKETIDIIFSDEKILAVISYLQSNAALITALINSDLKNSIQEQLANLLKNIFTENNANINNPKIAQPYASNIIFGSISTIFITWIKNNMQESPEELLNIINSYRKLTPIDIFP
>NZ_CP007646.1|WP_034982411.1|1759769_1760291_-|GNAT-family-N-acetyltransferase
MAVIYTRKATIDDLNKIMSIVEDARELFKNDKIPQWQGSYPDEKRFKEDINNEEAYVLIVDDEVAGIGVLTTERQENYDAIEEGSWKRDDDDYAAIHRAAISSKFRGMHLSNYLFSGLITIGVQKGYKDFRIDTHPGNERMKGLSEKFGFEKRGIIYVDEKIEPIRYAYELNL
>NZ_CP007646.1|WP_003700992.1|1758928_1759429_+|ECF-transporter-S-component
MKTNNLVNTHQLTLLAVIVAANVAIARVFLIPIPMTHGNVNLCDTGIFLAAWLFGSKKGGVVGGLSGFLLDLISGYPQYMVFSLIVHGLEGFIVGKLTEDKKISAKSLIVSLIAGVLFMVLGYLVSDSLLYKFSTGIIAVPMNVIQGLVGALVAVPLFWRLRKLVK
>NZ_CP007646.1|WP_034982413.1|1758093_1758939_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MENKQLLVAEDLSAVGDLSLTVATPILQCQNIPVAVLPTSVLSTQSEGFGTPAILPTENWIKSTFNHWSKEQLDFSGILIGYFNNQVVGQELLHFIESHSLDLVVIDPAFADDGAFYPGLDDNHLATIKELLQHATVTTPNLTEAKFLTGLTELDNSYESLSKLLLAMKKLIHPGGNVVITDIVFENKHGCVYEQDGEVTFCSYPQLPGHFYGSGDVFSALLTSFLWHGKDFHQAVKKTTKLTFNALMETATSHRERRYGINLSRLLQLLILENEGENYEN
>NZ_CP007646.1|WP_044005514.1|1757320_1757914_-|SdpI-family-protein
MKVIKNNILVIIMILMVLISIAVYDILPTRLPIHFTLTGTVDGTAPKLGGISFMPVMELILWLISSFGIKDINLKKVIDGIGIILFLAQLAIIGVALKPTANINMINAVALSCMIIIIALMTRNNKINRYIGIRTTRIMSSDKIWKKTNTFASNLLLVVGSIGFVLAIFLNSVSFIIIIVLLLIAIVASIVYSHYIK
>NZ_CP007646.1|WP_003700996.1|1756436_1757282_+|D-amino-acid-aminotransferase
MKQVGYYNGTIADLNELKVPATDRALYFGDGCYDATTFKNNVAFALEDHLDRFYNSCRLLEIDFPLNRDELKEKLYAVIDANEVDTGILYWQTSRGSGLRNHIFPEDSQPNLLIFTAPYGLVPFDTEYKLISREDTRFLHCNIKTLNLLPNVIASQKANESHCQEVVFHRGDRVTECAHSNILILKDGVLCSPPRDNLILPGITLKHLLQLAKENNIPTSEAPFTMDDLRNADEVIVSSSACLGIRAVELDGQPVGGKDGKTLKILQDAYAKKYNAETVSR
>NZ_CP007646.1|WP_044005513.1|1754406_1756308_+|peptidase-M13
MVNNELIKDDLYMAVNGDWLKTAKIPADKAATGGFYDLADDIEKTLMEDFANFMTSEATSDDRYLNEFIKYYRLVSNFEKRNADGFKPAKQYFDKITSLKDINDWQEKLYDLTMMGLPNPFPLYVEPDMKDTQHYALYASVPSLILPDKTYYKENHPQAEALLSVYRQMVLALFERAGYDNDFAQATLEKALAFDKSLAPVQKDSTERADYAKSYNKYSFEDYTAFSKRVDLGAFAKKLIGQTPDQVIVDEPKYYEALETLINPDTFENFKSWLLVKTLISVSTLLDDNTRVLAGTYSRALSGSKEAMKAQKAAFYLATGQFSQVVGLYYAHKYFGAKAKADVHHMVEKMIDVYKNRLASNDWLSDDTRQKAIVKLNTLGINVGYPDKLDPLYTKLVVDEDADLVTNDLNFTQISLKEHYDRWGKDVDRSRWEMPAHMVNAYYNPSFNIIVFPAAILQAPFYSLDQSSSENFGGIGAVIAHEISHAFDNNGAQFDEFGNLHNWWTDEDLKHFQGLAQDMIAEFDGLETEAGKVNGKLVVSENIADAGGLSCALEAAKSEPDVDLKAFFINWARIWRMKSSIERQKLLLSIDVHAPHVLRANVQPKNLADFYTTFEITSDDKMYLAPEKRVNIW
>NZ_CP007646.1|WP_003700998.1|1753718_1754276_+|energy-coupled-thiamine-transporter-ThiT
MYKEKLLILLEGALMAAIATVLSAVVPTVEWFDISLGIIPIVIFSIRRGLKAGLLSGLLWGLLPILIGRASILTVTQGILEYPVANMVVGLAGIYSNQIKQALSNNNWHVIFSRSLLAVFIAVFAKYFCHFIAGIIFWGSYAPKGMSPVLYSLFVNGGSFLFNLVLAGIVVVALERKADRIFALS
>NZ_CP007646.1|WP_034982418.1|1752749_1753364_-|TetR/AcrR-family-transcriptional-regulator
MKKTELKLESGLVKALENESFNQLTVAELVAAAGISRRSFYIYYKDKYEFLYDIRSRILKGIKQAMEADRKVIEQFEVRRLQTDEEKYLSTHDEFYKLAVFINENSDMVRTLFSRNATIDFYRDFMDLLKEEITIRNSFHKITYGTMIPTRYAEGIFAGEIISTIRIWVSNHNKESMESIDEFLDILGKIQIISPYHLFRPIKE
>NZ_CP007646.1|WP_044005518.1|1766245_1766725_-|VOC-family-protein
MNNGFLLVNHVGITVSNLEKSIEFYETLTGKKISNKDEIGGKRMAQTQGLDDTLIRYANLHLDNINMDILEYVEPKSTKANYSNEQISAMHLCFEVDDIETVVARMKEIGIEPEGEPIYFEKSDGLKAGFGTGVVYFKDPDGTNLELIAPKGPFQRERN
>NZ_CP007646.1|WP_044005519.1|1766753_1767593_-|aldo/keto-reductase
MIKSLSDRVELNNGTKIPGLELGVFQIPEDQTAEVVKNGIINGYRLIDTAAIYGNEKGTGIGIKEGIKVTGLKREDLFITSKVWNNHLTYDETIAAFNESLAKLDLDYLDLYLIHWPGQDAFEESWKALETLYAEGKIKAIGISNFEIHHLEKLKTFAKVVPVINQIELHPKLAQKELREYAANMDMKIQAWSPLMQGQLLKNEVILDIAKKHNKSAAQVILRWDIQQDILLNVKSVHTDRMIINASVFDFELDDEDMDRINMLNEDLRVGPNPDQFDF
>NZ_CP007646.1|WP_044005520.1|1767869_1769159_+|ISL3-family-transposase
MDNNIKLLLGITDPNLTIDPKYQYTSYIEEKIIKNSKALLCHLYLSYPMYCPNCKTLMLHNGTKVVNNVHLSSAGKKLVLSIRKQKYLCPECKKTATAKFKDTNYHDHFSNAVKAKLVRDLSLSRPMCEIAADSFTSSNTIIRSLESVENNFKVNRNWLPSHLSLDDFKSGKRFSSSGMSMCLINAVNHRIIDIIPERNNKFLRNYFIQYSYKARLSVMTITVDLYAPYRSLIKELFPNAFIIADKFHVVTQAYTAMNKIRIKVMKEYGAGTHEYRALKRFWKLFLKNQDNVDYHRYYPRINFKYAELSDSEVLDRLFDMSSELKTAYEYYQLLLQMYRKNSCQLLNLLTDTSSWNLPPEMRQALKTIKKHKVEIENSFVLPKLTNGPIEGVNNHIKVIKRIAYGYNNFKHFRLRILISLKNNVIFFST
>NZ_CP007646.1|WP_044005521.1|1769274_1769592_+|winged-helix-turn-helix-transcriptional-regulator
MDVIGGKWKPIILYNLRHQSLRTSELKKLIPNISQKMLTQQLRELEAADIINRKVYNQVPPKIEYSLSDYGQSLSTVLSDLCTWGEMHVDMLKKRGEDVELVYYD
>NZ_CP007646.1|WP_034982402.1|1769705_1770470_-|iron-export-ABC-transporter-permease-subunit-FetB
MSQLSVNNLSLALAFALVLVAVYISNREKLGLTKDIFYSISRAIVQLVIVGYILKYIFNVNNVVLTAAMSFFIVLNAAYNAHKRNPNDHKSYFNSLLAIFVSTYVTMGVLVASGSIRFIPSQIVPISGMIASNSMVAIGLCYRNLNTLFKNQRQQVLEKLALGASMKQASLPLLHASIKTAMQPTIDSAKTVGLVSLPGMMSGLIFAGVDPVRAIKYQIMVTFMLLSATSLGSIIAGYRTYKDYYNEKLQLRIK
>NZ_CP007646.1|WP_044005522.1|1770450_1771104_-|ATP-binding-cassette-domain-containing-protein
MAILSLQNVGYKVDTNEILKNINLDVNEYEFITITGPSGGGKSTLLKIIATLLTATTGEIFFDGKNQDEYAITEYRQQVSYCFQQPSLFGETVFDNLSFPYEIRQKEFDEKSAIEALKSVNLPETYLHKDINSLSGGERQRVALLRNTMFLPKVLLLDEVTVGLDARSIEIVHEFIDKIWKQGVTILQITHHEGEIKQANKIIWVEEGMIKDVTTKR
>NZ_CP007646.1|WP_003700975.1|1771252_1772479_-|OFA-family-MFS-transporter
MRSNRYVVALAGVIFHLMIGSVYAWSVYAKPIASQTSWSESAISFAFSLAIFFLGMSAAFMGRLVEKFGPTVTGTISALLFGTGIILTGVSIHLNQLWMLYLSYGVIGGLGLGSGYVTPVSTIIKWFPDKRGLATGLAIMGFGFAALLTSPIAQRLMSVVGLETTFYILGAFYMIVMLIAAQFIKRPKEGDVPEVAVAKGNKVSLGAQLTANQALKTKAFYSLWFMLFINITCGIGLVSAASPMAQEMTAMNAGAAAVMVGIIGLFNGFGRLIWATLSDYIGRPLTFSLIFIVDIIMLATLLIFHVPMVFVVALCLLMSCYGAGFSVIPAYLGDVFGTKELGAIHGYILTAWAMAGMVGPVLLSYTHQMLHSYATTIITFIIVDMVALFVSFWVQRDILRIKKQVFEK
>NZ_CP007646.1|WP_044005523.1|1772760_1773255_+|peroxiredoxin
MKITRHNEPLSTNGTPVDVNGVFPEFTVQNANGENVSSSDLLKKVTFISVVPDINTRVCSISTKKFNQDVDKYSNIAFYTVSTNTIDEQANWCAAEGVKNMQLLSDKAFDFGKNTGLYVADNDTDARSIWVLDNDGKVLYRELVIEQTNEPDYESVLQFLDSLA
>NZ_CP007646.1|WP_003709363.1|1773314_1773839_-|DUF308-domain-containing-protein
MYSENKRNFDVFSLVIGILLIFLGGYSLYRPDTTLAFISIMIGIIAIIKGIYELWFRRGISFWLGEKSGWLLAMGILDIILGCIFIFKIAVGASFIAIIFAIWFIFDALTQLATANFFKRLNKGYYWIIVVLSILSLIMGVMLLFNPILSALTIVWIISIYLITIGILKIIQAF
>NZ_CP007646.1|WP_044005525.1|1774261_1775482_-|transposase
MKTVITAKVRLYPNQEQVAQFKAVTKEYQRLCNLVSQWYFDNDCKVNRKKFNKEMYHYLRAESKEINSAMVQSTYRTVEARYKTVETQLKQRPYRYQDQNTGEWYHEKRDLSWLHKAVKFSRPQADYVRNINYSFVEQGSKISMNVLGQRIKVAFNGNYLNFFDPNYKLGTAKLVQLKKHWFLHIPVTIETDDWEKEHNQHIIGLDRGLRQIVTSYDEKGKTSFKNGKAIAYKRREYAYLRSQLQSKGTKSAKRKLKRLSQKENRWISDVNHCLSKTLVDTYGQNSLFVLEDLSGVTFEKTNSNKNQTRELHSWAFYDLQTKLAYKARKSQSQVLIVSAKYTSQRCPKCGQIRKENRNYRIHRYDCVFCGFKTNDDRIGAMNLYELGKQYISGIENPKFELTNVTD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Identity
NZ_CP007646_1	1.7\|810651\|36\|NZ_CP007646\|PILER-CR,CRISPRCasFinder,CRT	810651-810686	36	NZ_CP007646.1	912588-912623	1.0
NZ_CP007646_1	1.12\|811025\|35\|NZ_CP007646\|PILER-CR,CRISPRCasFinder,CRT	811025-811059	35	NZ_CP007648.1	7650-7684	1.0
NZ_CP007646_1	1.18\|811465\|38\|NZ_CP007646\|PILER-CR,CRISPRCasFinder,CRT	811465-811502	38	NZ_CP007648.1	23466-23503	1.0

1. spacer 1.7|810651|36|NZ_CP007646|PILER-CR,CRISPRCasFinder,CRT matches to position: 912588-912623, mismatch: 0, identity: 1.0

accttggtggtgttgatggtttagttcacgtttctg	CRISPR spacer
accttggtggtgttgatggtttagttcacgtttctg	Protospacer
************************************

2. spacer 1.12|811025|35|NZ_CP007646|PILER-CR,CRISPRCasFinder,CRT matches to position: 7650-7684, mismatch: 0, identity: 1.0

ctcaattttattgacgtactcagtaccgcttttac	CRISPR spacer
ctcaattttattgacgtactcagtaccgcttttac	Protospacer
***********************************

3. spacer 1.18|811465|38|NZ_CP007646|PILER-CR,CRISPRCasFinder,CRT matches to position: 23466-23503, mismatch: 0, identity: 1.0

accaaatcttcttctgttagttcccaagcctctttacc	CRISPR spacer
accaaatcttcttctgttagttcccaagcctctttacc	Protospacer
**************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP007646_1	1.12\|811025\|35\|NZ_CP007646\|PILER-CR,CRISPRCasFinder,CRT	811025-811059	35	NZ_CP007648	Lactobacillus salivarius strain JCM1046 plasmid pMP1046B, complete sequence	7650-7684	0	1.0
NZ_CP007646_1	1.18\|811465\|38\|NZ_CP007646\|PILER-CR,CRISPRCasFinder,CRT	811465-811502	38	NZ_CP007648	Lactobacillus salivarius strain JCM1046 plasmid pMP1046B, complete sequence	23466-23503	0	1.0
NZ_CP007646_1	1.22\|811765\|34\|NZ_CP007646\|PILER-CR,CRISPRCasFinder,CRT	811765-811798	34	AP014358	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S39-C94, * SEQUENCING IN PROGRESS *	536-569	8	0.765

1. spacer 1.12|811025|35|NZ_CP007646|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007648 (Lactobacillus salivarius strain JCM1046 plasmid pMP1046B, complete sequence) position: , mismatch: 0, identity: 1.0

ctcaattttattgacgtactcagtaccgcttttac	CRISPR spacer
ctcaattttattgacgtactcagtaccgcttttac	Protospacer
***********************************

2. spacer 1.18|811465|38|NZ_CP007646|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007648 (Lactobacillus salivarius strain JCM1046 plasmid pMP1046B, complete sequence) position: , mismatch: 0, identity: 1.0

accaaatcttcttctgttagttcccaagcctctttacc	CRISPR spacer
accaaatcttcttctgttagttcccaagcctctttacc	Protospacer
**************************************

3. spacer 1.22|811765|34|NZ_CP007646|PILER-CR,CRISPRCasFinder,CRT matches to AP014358 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S39-C94, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.765

tctatcttctggcataaagatttcataacctacc	CRISPR spacer
tgtgttttctggcataaagacttcataaccatta	Protospacer
* *.*.**************.*********  .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

6461 : 17133

Bacillus_virus(16.67%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044004249.1\|6461_9014_+	DNA gyrase subunit A	G3M9Z5	Bacillus_virus	6.9e-112	36.9
WP_003703382.1\|9232_9523_+	30S ribosomal protein S6	NA	NA	NA	NA
WP_003708930.1\|9563_10115_+	single-stranded DNA-binding protein	A8ATZ7	Listeria_phage	1.1e-43	53.8
WP_003701427.1\|10136_10373_+	30S ribosomal protein S18	NA	NA	NA	NA
WP_044004256.1\|10562_11852_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	4.8e-45	30.0
WP_044004258.1\|11937_12801_-	NAD(P)-dependent oxidoreductase	A0A077SLF7	Escherichia_phage	3.2e-21	26.8
WP_044004260.1\|12948_13962_+	glycosyltransferase	NA	NA	NA	NA
WP_044005558.1\|14189_14972_+	M23 family metallopeptidase	A0A7K9	Microcystis_virus	2.6e-06	37.5
WP_044004262.1\|15210_17133_+	asparagine synthase (glutamine-hydrolyzing)	R4TIC1	Phaeocystis_globosa_virus	3.9e-27	27.3

DBSCAN-SWA_2

27908 : 103289

Bacillus_phage(27.27%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044004280.1\|27908_29198_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	9.0e-44	29.7
WP_034982753.1\|29439_30786_+	threonine/serine exporter family protein	NA	NA	NA	NA
WP_003707363.1\|30800_31361_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_003702035.1\|31559_32474_+	EamA family transporter	NA	NA	NA	NA
WP_034982754.1\|32642_34445_-	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	6.3e-136	43.0
WP_044004286.1\|34798_35716_+	cysteine synthase family protein	C3U2M1	Lactococcus_phage	9.2e-59	40.9
WP_034982756.1\|35731_36874_+	PLP-dependent transferase	A0A0B5JD48	Pandoravirus	1.3e-17	26.4
WP_044004288.1\|37029_38139_+	iron-containing alcohol dehydrogenase family protein	NA	NA	NA	NA
WP_044004290.1\|38223_38658_+	peptide-methionine (R)-S-oxide reductase MsrB	NA	NA	NA	NA
WP_034982758.1\|38772_39069_+	type II toxin-antitoxin system RelB/DinJ family antitoxin	NA	NA	NA	NA
WP_003701461.1\|39174_39375_+	type II toxin-antitoxin system YafQ family toxin	NA	NA	NA	NA
WP_044004295.1\|39464_40856_-	L,D-transpeptidase family protein	NA	NA	NA	NA
WP_003705682.1\|41053_41503_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_044004299.1\|41514_43248_+	ABC transporter ATP-binding protein	F2Y352	Organic_Lake_phycodnavirus	6.0e-19	28.5
WP_034982761.1\|43240_45022_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.3e-50	28.2
WP_044004301.1\|45141_45441_+	hypothetical protein	NA	NA	NA	NA
WP_148305433.1\|45522_45873_+	hypothetical protein	NA	NA	NA	NA
WP_034982765.1\|45889_47674_+	DUF87 domain-containing protein	NA	NA	NA	NA
WP_044004305.1\|49296_49926_-	zinc ribbon domain-containing protein	NA	NA	NA	NA
WP_003701471.1\|50047_50875_+	sugar-phosphatase	NA	NA	NA	NA
WP_003701473.1\|51047_51758_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.1e-43	40.8
WP_172412479.1\|51768_53652_+	cell wall metabolism sensor histidine kinase WalK	W8CYF6	Bacillus_phage	1.1e-37	35.4
WP_044004313.1\|53641_54979_+	hypothetical protein	NA	NA	NA	NA
WP_044004315.1\|54990_55791_+	two-component system regulatory protein YycI	NA	NA	NA	NA
WP_003702729.1\|55862_56213_+	MmcQ/YjbR family DNA-binding protein	NA	NA	NA	NA
WP_034982774.1\|56285_57089_+	MBL fold metallo-hydrolase	A0A2I7SDH3	Paenibacillus_phage	7.3e-36	34.9
WP_044004318.1\|57187_58492_+	trypsin-like peptidase domain-containing protein	A0A1B1IT49	uncultured_Mediterranean_phage	4.3e-17	30.8
WP_044004321.1\|58856_59336_+	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	NA	NA	NA	NA
WP_044004323.1\|59589_60981_-	MFS transporter	NA	NA	NA	NA
WP_172400030.1\|61135_62263_-	endonuclease	NA	NA	NA	NA
WP_034982777.1\|62408_63638_+	accessory Sec system protein translocase subunit SecY2	NA	NA	NA	NA
WP_044004325.1\|63661_65263_+	accessory Sec system protein Asp1	NA	NA	NA	NA
WP_034982779.1\|65255_66812_+	accessory Sec system protein Asp2	NA	NA	NA	NA
WP_080739298.1\|66801_67725_+	accessory Sec system protein Asp3	NA	NA	NA	NA
WP_034982780.1\|67737_70089_+	accessory Sec system translocase SecA2	NA	NA	NA	NA
WP_170102506.1\|70108_70273_+	hypothetical protein	NA	NA	NA	NA
WP_080739299.1\|73537_73876_+	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_148305434.1\|73983_74745_-\|transposase	IS3 family transposase	A0A0C5AC89	Paenibacillus_phage	4.1e-52	45.9
WP_044004331.1\|74935_75568_-	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	7.8e-33	40.5
WP_034982086.1\|75738_77238_+	accessory Sec system glycosyltransferase GtfA	NA	NA	NA	NA
WP_044004336.1\|77376_78285_+	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	1.7e-09	40.4
WP_034982237.1\|78320_79646_+	accessory Sec system glycosylation chaperone GtfB	NA	NA	NA	NA
WP_080739364.1\|79838_80747_+	nucleotide sugar synthetase	NA	NA	NA	NA
WP_044004339.1\|82900_83905_+	nucleotide sugar synthetase	NA	NA	NA	NA
WP_034982096.1\|83922_84831_+	glycosyltransferase family 2 protein	K7Z8A5	Megavirus	2.8e-07	33.0
WP_080739300.1\|84827_85847_+	sugar transferase	NA	NA	NA	NA
WP_044004342.1\|85875_86748_+	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	4.1e-08	36.0
WP_034998092.1\|88334_88853_+\|transposase	transposase	A0A1B1P776	Bacillus_phage	1.0e-14	36.5
WP_034982102.1\|92365_93688_+	MATE family efflux transporter	NA	NA	NA	NA
WP_034982104.1\|93736_95218_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2I4R674	Erysipelothrix_phage	1.5e-31	26.7
WP_034982106.1\|95583_96168_+	peptidylprolyl isomerase	A0A076FI46	Aureococcus_anophage	2.2e-26	43.5
WP_034982108.1\|96318_97038_+	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	A0A2I7RZT1	Vibrio_phage	6.0e-05	26.2
WP_034982110.1\|97090_98449_-	glutamate--cysteine ligase	NA	NA	NA	NA
WP_003703180.1\|98650_98881_+	hypothetical protein	NA	NA	NA	NA
WP_044004346.1\|99006_101115_+\|protease	ATP-dependent Clp protease ATP-binding subunit	K4FB40	Cronobacter_phage	5.1e-121	38.9
WP_034982115.1\|101326_101803_+	universal stress protein	NA	NA	NA	NA
WP_148305435.1\|101871_102816_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.2e-40	37.8
WP_034983678.1\|102770_103289_-\|transposase	transposase	A0A1B1P776	Bacillus_phage	2.3e-14	35.8

DBSCAN-SWA_3

712753 : 721526

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011475856.1\|712753_713236_+	pantetheine-phosphate adenylyltransferase	A0A1B1IVQ3	uncultured_Mediterranean_phage	1.6e-22	41.1
WP_003700035.1\|713232_714267_+	PDZ domain-containing protein	NA	NA	NA	NA
WP_014568323.1\|714579_715293_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	6.3e-39	37.8
WP_003703354.1\|715311_715560_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_044004813.1\|715559_716234_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_044004815.1\|716235_718461_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.0e-143	40.0
WP_044004817.1\|718436_719888_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.3e-63	35.4
WP_034982877.1\|719888_720926_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	2.6e-62	42.3
WP_003700046.1\|720938_721526_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	1.1e-25	36.9

DBSCAN-SWA_4

726449 : 788629

Streptococcus_phage(23.81%)

transposase,integrase,tRNA

attL 751145:751164|attR 797346:797365

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080739321.1\|726449_727868_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.4e-42	38.5
WP_158423221.1\|728025_728178_+	hypothetical protein	NA	NA	NA	NA
WP_052399043.1\|728236_728983_+	DUF805 domain-containing protein	D6PSS5	Lactobacillus_phage	2.5e-06	29.1
WP_044004823.1\|729079_729448_+	hypothetical protein	NA	NA	NA	NA
WP_044004825.1\|729882_731616_+	hypothetical protein	NA	NA	NA	NA
WP_052399044.1\|732315_732675_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_044004827.1\|732945_733383_+	hypothetical protein	NA	NA	NA	NA
WP_052399045.1\|734609_735053_+	hypothetical protein	U3PCM7	Lactobacillus_phage	2.1e-08	29.9
WP_052399046.1\|735062_735734_+\|integrase	site-specific integrase	S5MBZ0	Brevibacillus_phage	1.1e-29	33.3
WP_003700053.1\|736234_737728_-	cardiolipin synthase	NA	NA	NA	NA
WP_003700054.1\|737840_738728_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_003700056.1\|738980_739190_-	hypothetical protein	NA	NA	NA	NA
WP_011475862.1\|740351_742043_+\|tRNA	arginine--tRNA ligase	A0A2I2L3K1	Orpheovirus	6.6e-79	32.9
WP_003700061.1\|742154_742844_+	helix-hairpin-helix domain-containing protein	NA	NA	NA	NA
WP_003706127.1\|742887_743364_+	ComE operon protein 2	A7KUY9	Bacillus_phage	1.5e-33	55.0
WP_003700067.1\|745648_746671_+	DNA polymerase III subunit delta	NA	NA	NA	NA
WP_003700069.1\|746689_747736_-	type 2 isopentenyl-diphosphate Delta-isomerase	NA	NA	NA	NA
WP_003700070.1\|747751_748819_-	phosphomevalonate kinase	NA	NA	NA	NA
WP_034983138.1\|748843_749812_-	diphosphomevalonate decarboxylase	NA	NA	NA	NA
WP_034983140.1\|749824_750769_-	mevalonate kinase	NA	NA	NA	NA
WP_044004834.1\|751016_753806_+	DEAD/DEAH box helicase family protein	A0A1X9I5C8	Streptococcus_phage	1.2e-85	28.3
751145:751164	attL	NA	NA	NA	NA
WP_044005594.1\|753938_754433_+	DUF5590 domain-containing protein	NA	NA	NA	NA
WP_034983144.1\|754450_755632_+	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_003700078.1\|755644_756946_+\|tRNA	asparagine--tRNA ligase	A0A2K9L2U8	Tupanvirus	7.4e-54	29.6
WP_003706143.1\|757053_757761_+	DnaD domain protein	A0A0N7AE27	Bacillus_phage	1.4e-11	37.8
WP_034983146.1\|757775_758417_+	endonuclease III	NA	NA	NA	NA
WP_003706147.1\|758472_758991_+	peptide-methionine (S)-S-oxide reductase MsrA	NA	NA	NA	NA
WP_003710005.1\|759014_759887_+	YitT family protein	NA	NA	NA	NA
WP_011475868.1\|759957_760965_+	sugar transferase	NA	NA	NA	NA
WP_011475869.1\|760961_761753_+	glycosyl transferase	A0A2K9L4Z6	Tupanvirus	6.4e-08	35.2
WP_011475870.1\|761739_762687_+	glycosyltransferase	R9S8I6	Prochlorococcus_phage	3.8e-07	34.0
WP_011475871.1\|762702_762888_+	hypothetical protein	NA	NA	NA	NA
WP_003703786.1\|762890_763076_+	hypothetical protein	NA	NA	NA	NA
WP_003703800.1\|763178_763991_-	kinase/pyrophosphorylase	NA	NA	NA	NA
WP_003694124.1\|764241_764427_+	30S ribosomal protein S21	NA	NA	NA	NA
WP_003706153.1\|764445_764889_+	GatB/YqeY domain-containing protein	A0A292GL36	Xanthomonas_phage	7.2e-17	37.7
WP_011475873.1\|764990_765134_+	hypothetical protein	NA	NA	NA	NA
WP_011475874.1\|765214_766045_-\|integrase	site-specific integrase	NA	NA	NA	NA
WP_034983150.1\|766049_766946_-	YitT family protein	M1Q1P6	Streptococcus_phage	5.1e-54	37.3
WP_011475876.1\|767121_767910_+	4-hydroxy-tetrahydrodipicolinate reductase	NA	NA	NA	NA
WP_014568347.1\|767906_769121_+\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	6.7e-49	34.8
WP_011475878.1\|769117_771025_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	4.7e-57	31.3
WP_003700096.1\|771042_771999_+	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	2.0e-117	61.5
WP_014568348.1\|772016_772520_+	dihydrofolate reductase	G3MBI7	Bacillus_virus	2.2e-30	44.6
WP_014568349.1\|772696_773557_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.4e-56	42.4
WP_003700099.1\|773558_774020_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_034983153.1\|774023_774980_+	aldo/keto reductase	NA	NA	NA	NA
WP_034983154.1\|775771_776701_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_003700105.1\|776705_777305_+	YpmS family protein	NA	NA	NA	NA
WP_003703777.1\|777316_777544_+	YozE family protein	NA	NA	NA	NA
WP_003700107.1\|777602_778460_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_158423222.1\|779705_779942_-\|transposase	transposase	A0A1X9I619	Streptococcus_phage	1.5e-13	50.7
WP_051454400.1\|779931_780630_-\|transposase	transposase	A0A1X9I619	Streptococcus_phage	2.1e-55	50.0
WP_044004856.1\|787339_788629_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	4.0e-44	29.5
797346:797365	attR	NA	NA	NA	NA

DBSCAN-SWA_5

814944 : 823683

Brevibacillus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044004866.1\|814944_817419_+	ATP-dependent RecD-like DNA helicase	A0A0K2FLP8	Brevibacillus_phage	9.4e-58	27.9
WP_052399049.1\|818979_819582_-	hypothetical protein	NA	NA	NA	NA
WP_051454353.1\|819633_820782_-	NINE protein	A0A0A8WJ41	Clostridium_phage	2.9e-17	30.7
WP_034982467.1\|820783_820981_-	hypothetical protein	Q9T1Z0	Lactococcus_phage	1.1e-14	64.5
WP_034982525.1\|820986_821550_-	hypothetical protein	NA	NA	NA	NA
WP_044004868.1\|821596_822127_-	PH domain-containing protein	A0A0F6N4L7	Staphylococcus_phage	1.4e-27	45.5
WP_143455587.1\|822152_822764_-	hypothetical protein	NA	NA	NA	NA
WP_034982470.1\|822818_823244_-	ImmA/IrrE family metallo-endopeptidase	Q9T201	Bacillus_phage	1.7e-07	36.7
WP_034982471.1\|823257_823683_-	helix-turn-helix domain-containing protein	A0A2P1JU09	Anoxybacillus_phage	4.4e-24	43.3

DBSCAN-SWA_6

1184125 : 1243377

Bacillus_phage(27.27%)

transposase,holin,bacteriocin,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003700632.1\|1184125_1184479_-\|holin	phage holin family protein	NA	NA	NA	NA
WP_003700633.1\|1184482_1184821_-	PspC domain-containing protein	NA	NA	NA	NA
WP_034982336.1\|1184833_1186219_-	two-component sensor histidine kinase	W8CYF6	Bacillus_phage	5.1e-29	32.5
WP_003706545.1\|1186218_1186920_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.1e-35	37.6
WP_034982335.1\|1186935_1188063_-	PDZ domain-containing protein	NA	NA	NA	NA
WP_044005048.1\|1188212_1188731_+\|transposase	transposase	A0A1B1P776	Bacillus_phage	6.6e-14	35.8
WP_080739335.1\|1188733_1188994_+	hypothetical protein	NA	NA	NA	NA
WP_044005049.1\|1189013_1189631_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	3.8e-32	40.6
WP_099450942.1\|1189737_1190869_-	peptide chain release factor 2	NA	NA	NA	NA
WP_003700639.1\|1190943_1193307_-	preprotein translocase subunit SecA	NA	NA	NA	NA
WP_034983102.1\|1193430_1194609_-	MFS transporter	NA	NA	NA	NA
WP_003700641.1\|1194732_1195287_-	ribosome-associated translation inhibitor RaiA	NA	NA	NA	NA
WP_003700642.1\|1195466_1196153_-	ComF family protein	NA	NA	NA	NA
WP_034983089.1\|1196149_1197487_-	DEAD/DEAH box helicase family protein	A0A1X9I5S6	Streptococcus_phage	1.7e-77	41.1
WP_003700645.1\|1197566_1198658_-	undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase	NA	NA	NA	NA
WP_003700646.1\|1198808_1200638_-	APC family permease	NA	NA	NA	NA
WP_034983088.1\|1200821_1203224_-	cation-translocating P-type ATPase	A0A218MNH6	uncultured_virus	4.9e-19	22.9
WP_003700648.1\|1203419_1205042_-	chaperonin GroEL	A0A219YK78	uncultured_virus	1.6e-159	56.4
WP_003706535.1\|1205071_1205356_-	co-chaperone GroES	A0A221S422	uncultured_virus	7.3e-15	47.8
WP_034983087.1\|1205551_1206181_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_003710514.1\|1206284_1206926_-	redox-sensing transcriptional repressor Rex	NA	NA	NA	NA
WP_034983086.1\|1207099_1209049_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L0W2	Tupanvirus	3.7e-49	29.4
WP_003706528.1\|1210168_1210675_-	ribosomal protein S18-alanine N-acetyltransferase	NA	NA	NA	NA
WP_011476225.1\|1210679_1211411_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_034983085.1\|1211562_1212543_+	asparaginase	NA	NA	NA	NA
WP_044005051.1\|1212716_1214006_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	6.2e-45	30.0
WP_003700659.1\|1214874_1215756_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	6.5e-78	62.0
WP_003700660.1\|1215755_1216100_-	DNA replication initiation control protein YabA	NA	NA	NA	NA
WP_003700662.1\|1216114_1217107_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	2.6e-35	30.9
WP_003700663.1\|1217141_1217768_-	dTMP kinase	M1PSC7	Streptococcus_phage	6.9e-50	51.0
WP_011476227.1\|1217887_1218127_-	YaaL family protein	NA	NA	NA	NA
WP_003700665.1\|1218140_1218740_-	recombination protein RecR	NA	NA	NA	NA
WP_080739336.1\|1218766_1219081_-	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_034983631.1\|1219098_1220838_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	6.6e-58	38.9
WP_044005603.1\|1221044_1221512_-	nucleoside deaminase	NA	NA	NA	NA
WP_003700669.1\|1221558_1222170_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_003700670.1\|1222372_1222603_+	glutaredoxin-like protein NrdH	X2KRY7	Enterococcus_phage	2.7e-12	40.3
WP_003700671.1\|1222599_1222983_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	R4JF54	Bacillus_phage	5.8e-15	38.7
WP_003700672.1\|1222963_1225135_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	3.5e-266	63.9
WP_003700673.1\|1225152_1226133_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A096XT60	Enterococcus_phage	4.3e-123	66.5
WP_011476230.1\|1226206_1228780_-	bifunctional lysylphosphatidylglycerol flippase/synthetase MprF	NA	NA	NA	NA
WP_003700675.1\|1228865_1229327_-	hypothetical protein	NA	NA	NA	NA
WP_003702605.1\|1229421_1229790_-	50S ribosomal protein L7/L12	NA	NA	NA	NA
WP_003700677.1\|1229861_1230365_-	50S ribosomal protein L10	NA	NA	NA	NA
WP_003700678.1\|1230609_1231302_-	50S ribosomal protein L1	NA	NA	NA	NA
WP_003700679.1\|1231404_1231830_-	50S ribosomal protein L11	NA	NA	NA	NA
WP_003702631.1\|1231952_1232513_-	transcription termination/antitermination protein NusG	F5B3X4	Synechococcus_phage	7.4e-11	28.4
WP_003700681.1\|1232627_1232795_-	preprotein translocase subunit SecE	NA	NA	NA	NA
WP_003700682.1\|1232814_1232967_-	50S ribosomal protein L33	NA	NA	NA	NA
WP_044005052.1\|1233563_1234310_-	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_003700685.1\|1234309_1234717_-	Mini-ribonuclease 3	NA	NA	NA	NA
WP_003702615.1\|1234709_1236122_-\|tRNA	cysteine--tRNA ligase	A0A2K9V966	Bandra_megavirus	4.3e-55	29.9
WP_003700687.1\|1236273_1237761_-\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_044005053.1\|1237891_1239004_-	PIN/TRAM domain-containing protein	NA	NA	NA	NA
WP_044005055.1\|1239029_1240403_-	DNA repair protein RadA	NA	NA	NA	NA
WP_003700690.1\|1240420_1240957_-	dUTP diphosphatase	J9PV85	Bacillus_phage	1.0e-41	51.4
WP_003702618.1\|1241112_1241391_+	N-acetyltransferase	NA	NA	NA	NA
WP_044005058.1\|1241479_1242814_+	C1 family peptidase	R4TV59	Phaeocystis_globosa_virus	5.2e-71	34.0
WP_003702606.1\|1243017_1243377_+\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA

DBSCAN-SWA_7

1289667 : 1341470

Streptococcus_phage(38.46%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044005086.1\|1289667_1290957_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	2.8e-45	30.5
WP_044005088.1\|1291104_1292928_-	glycoside hydrolase family 13 protein	NA	NA	NA	NA
WP_044005090.1\|1292908_1295332_-	glycogen/starch/alpha-glucan phosphorylase	Q8B3H5	Iris_mild_mosaic_virus	1.2e-12	42.5
WP_044005092.1\|1295360_1296791_-	glycogen synthase GlgA	NA	NA	NA	NA
WP_044005094.1\|1296790_1297963_-	glucose-1-phosphate adenylyltransferase subunit GlgD	NA	NA	NA	NA
WP_044005096.1\|1297952_1299095_-	glucose-1-phosphate adenylyltransferase	H9NC64	Sphingomonas_phage	9.5e-13	26.7
WP_044005098.1\|1299195_1301145_-	1,4-alpha-glucan branching protein GlgB	NA	NA	NA	NA
WP_044005100.1\|1301349_1303113_-	alpha-glycosidase	NA	NA	NA	NA
WP_044005102.1\|1303152_1304262_-	hypothetical protein	NA	NA	NA	NA
WP_044005104.1\|1304351_1305686_-	NADP-specific glutamate dehydrogenase	NA	NA	NA	NA
WP_044005106.1\|1305872_1307246_-	NAD-dependent succinate-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_044005108.1\|1307424_1307907_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_003703026.1\|1307924_1308239_-	hypothetical protein	NA	NA	NA	NA
WP_044005110.1\|1308919_1310209_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	3.6e-45	30.0
WP_003705188.1\|1310347_1311715_-	magnesium transporter	NA	NA	NA	NA
WP_044005112.1\|1311732_1312620_-	RluA family pseudouridine synthase	A0A2H4UV25	Bodo_saltans_virus	1.9e-05	26.5
WP_003703056.1\|1312609_1313416_-	NAD kinase	NA	NA	NA	NA
WP_044005115.1\|1313436_1314081_-	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_044005117.1\|1314181_1316257_-	DNA topoisomerase III	A0A1X9I6W8	Streptococcus_phage	1.2e-34	30.6
WP_044005119.1\|1316331_1316868_+	sugar O-acetyltransferase	NA	NA	NA	NA
WP_044005120.1\|1316959_1318249_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	3.6e-45	30.0
WP_044005122.1\|1318428_1319763_-	purine permease	Q9KX94	Enterobacteria_phage	1.9e-28	26.7
WP_044005124.1\|1319765_1320344_-	xanthine phosphoribosyltransferase	NA	NA	NA	NA
WP_044005126.1\|1320552_1321209_-	glycoside hydrolase family 73 protein	A0A0K2CP65	Brevibacillus_phage	4.6e-28	46.8
WP_044005128.1\|1321241_1321838_-	ECF transporter S component	NA	NA	NA	NA
WP_044005130.1\|1322257_1323883_-	NAD-dependent malic enzyme	NA	NA	NA	NA
WP_044005132.1\|1324025_1324907_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_004563791.1\|1324972_1325407_-	winged helix DNA-binding protein	NA	NA	NA	NA
WP_044005134.1\|1325743_1326277_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_044005136.1\|1326304_1326748_-	universal stress protein	NA	NA	NA	NA
WP_004564271.1\|1326870_1327308_-	CopY/TcrY family copper transport repressor	NA	NA	NA	NA
WP_044005139.1\|1328758_1329964_+	DUF1002 domain-containing protein	NA	NA	NA	NA
WP_044005141.1\|1329975_1330584_+	DedA family protein	NA	NA	NA	NA
WP_044005143.1\|1330648_1331845_-	acetate kinase	NA	NA	NA	NA
WP_044005145.1\|1331926_1332496_-	acetyltransferase	NA	NA	NA	NA
WP_044005147.1\|1332603_1334025_-	anion permease	NA	NA	NA	NA
WP_044005149.1\|1334117_1335503_-	flavocytochrome c	A0A2P0ZL82	Lactobacillus_phage	1.7e-56	32.9
WP_044005151.1\|1335522_1336905_-	class II fumarate hydratase	NA	NA	NA	NA
WP_003703609.1\|1337199_1337493_+	YbaN family protein	NA	NA	NA	NA
WP_143456852.1\|1337561_1338506_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.2e-40	37.8
WP_044005007.1\|1338460_1338979_-\|transposase	transposase	A0A1B1P776	Bacillus_phage	6.6e-14	35.8
WP_080739338.1\|1340558_1341470_-\|transposase	transposase	A0A1S5SBP9	Streptococcus_phage	7.1e-19	27.4

DBSCAN-SWA_8

1357370 : 1420221

Erysipelothrix_phage(65.52%)

transposase,tail,holin,integrase,terminase,tRNA,capsid,portal,head,protease

attL 1383375:1383390|attR 1425882:1425897

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044005161.1\|1357370_1358660_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	2.8e-45	30.2
WP_044005165.1\|1359473_1360652_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_044005167.1\|1360664_1362752_-	SAM-dependent DNA methyltransferase	A0A220A2U5	Liberibacter_phage	2.4e-22	22.7
WP_044005169.1\|1363042_1363372_-	hypothetical protein	NA	NA	NA	NA
WP_087448619.1\|1363456_1364314_-	Mrr restriction system protein	NA	NA	NA	NA
WP_180707232.1\|1364655_1364817_+	hypothetical protein	NA	NA	NA	NA
WP_044005171.1\|1365016_1366291_-	hypothetical protein	NA	NA	NA	NA
WP_044005173.1\|1366406_1367594_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_044005175.1\|1367597_1369226_-	SAM-dependent DNA methyltransferase	A0A2H4PQP4	Staphylococcus_phage	1.3e-28	27.5
WP_044005177.1\|1369231_1372306_-	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	1.0e-24	24.5
WP_044005179.1\|1372338_1372560_-	helix-turn-helix transcriptional regulator	A0A2K5B263	Erysipelothrix_phage	6.1e-17	67.2
WP_044005181.1\|1372573_1375189_-	helicase	NA	NA	NA	NA
WP_080739378.1\|1375193_1376153_-	DUF1837 domain-containing protein	NA	NA	NA	NA
WP_148305438.1\|1376882_1377410_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_044005185.1\|1377514_1377712_+	hypothetical protein	A0A2I4R673	Erysipelothrix_phage	1.7e-07	40.4
WP_044005187.1\|1377698_1378031_+	hypothetical protein	NA	NA	NA	NA
WP_044005189.1\|1378014_1379157_+	DUF2800 domain-containing protein	A0A2K5B2A8	Erysipelothrix_phage	3.3e-114	55.1
WP_044005191.1\|1379158_1379710_+	DUF2815 family protein	A0A2K5B2A9	Erysipelothrix_phage	2.2e-71	72.1
WP_044005193.1\|1379760_1381695_+	DNA polymerase	A0A2K5B2B0	Erysipelothrix_phage	1.7e-224	58.5
WP_044005609.1\|1381789_1382188_+	hypothetical protein	A0A2K5B270	Erysipelothrix_phage	8.4e-17	37.3
WP_044005195.1\|1382190_1384440_+	primase C-terminal domain-containing protein	E4ZFK6	Streptococcus_phage	2.0e-211	48.8
1383375:1383390	attL	NA	NA	NA	NA
WP_044005197.1\|1384634_1384937_+	VRR-NUC domain-containing protein	A0A2K5B272	Erysipelothrix_phage	1.9e-21	56.7
WP_044005199.1\|1384896_1386279_+	DEAD/DEAH box helicase	A0A2K5B273	Erysipelothrix_phage	1.3e-154	65.9
WP_044005201.1\|1386247_1386718_+	hypothetical protein	NA	NA	NA	NA
WP_044005203.1\|1386852_1387230_+	HNH endonuclease	A0A2K5B276	Erysipelothrix_phage	1.8e-32	53.8
WP_044005205.1\|1387346_1387889_+\|terminase	terminase	A0A2K5B277	Erysipelothrix_phage	1.3e-57	59.0
WP_044005207.1\|1387888_1389118_+	DNA modification methylase	A0A2I4R670	Erysipelothrix_phage	5.2e-150	62.9
WP_044005209.1\|1389189_1389822_+	hypothetical protein	A0A2K5B280	Erysipelothrix_phage	4.3e-39	40.4
WP_044005211.1\|1389814_1390021_+	DUF5049 domain-containing protein	NA	NA	NA	NA
WP_044005213.1\|1390083_1391685_+\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	1.8e-251	78.8
WP_191980114.1\|1391712_1391874_+	hypothetical protein	NA	NA	NA	NA
WP_044005215.1\|1392235_1393492_+\|portal	phage portal protein	Q6DMU2	Streptococcus_phage	4.1e-150	62.1
WP_044005217.1\|1393488_1394151_+\|protease	Clp protease ClpP	A0A2K5B288	Erysipelothrix_phage	1.2e-55	56.9
WP_044005219.1\|1394171_1395350_+\|capsid	phage major capsid protein	A0A2I4R671	Erysipelothrix_phage	2.0e-130	59.7
WP_003672647.1\|1395361_1395640_+\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_044005226.1\|1395640_1396021_+\|head	phage head closure protein	NA	NA	NA	NA
WP_003672651.1\|1396010_1396433_+\|holin	phage holin family protein	A0A2K5B2A2	Erysipelothrix_phage	1.5e-40	65.8
WP_003672653.1\|1396530_1396719_+	hypothetical protein	NA	NA	NA	NA
WP_044005229.1\|1396781_1398332_+	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	3.7e-84	34.7
WP_044005231.1\|1398318_1398723_+	recombinase	NA	NA	NA	NA
WP_044005233.1\|1398709_1400296_+	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	1.5e-125	47.3
WP_044005235.1\|1400539_1401913_-	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	2.5e-124	49.6
WP_003705249.1\|1401993_1403013_-	diacylglycerol kinase	A0A1V0SBJ0	Catovirus	1.5e-17	29.0
WP_003702437.1\|1403045_1404479_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_034982969.1\|1404478_1405942_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_003702422.1\|1405944_1406244_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_034982968.1\|1406395_1407541_-	CamS family sex pheromone protein	NA	NA	NA	NA
WP_034982967.1\|1407537_1409556_-	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	4.4e-106	34.9
WP_044005610.1\|1409572_1411795_-	DNA helicase PcrA	A7KV33	Bacillus_phage	2.9e-135	42.3
WP_034982965.1\|1411914_1413054_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
WP_034983499.1\|1418988_1420221_-\|integrase	site-specific integrase	H7BUX8	unidentified_phage	7.7e-85	41.1
1425882:1425897	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_CP007646.1|WP_044005211.1|1389814_1390021_+|DUF5049-domain-containing-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP007646.1|WP_044005211.1|1389814_1390021_+|DUF5049-domain-containing-protein

1389814_1390021_+

68 aa aa

1357370-1420221

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP007647_1	Orphan	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	1358706-1358750	2

1. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to NZ_CP007646 position: 1358706-1358750, mismatch: 2

attaaaattttggcatcagtcctttttgacaaagaacctttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaacccatataa	Protospacer
**************************************. *****

4. NZ_CP007647

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP007647_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP007647_1

216880-216994

Orphan

Consensus_repeat	Method
TTGAGGCAATGTAGTACCTATCTTTCCCATTAATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP007647_1

>merge|NZ_CP007647|1|216880-216994|CRISPRCasFinder
TTGAGGCAATGTAGTACCTATCTTTCCCATTAATTATTAAAATTTTGGCATCAGTCCTTTTTGACAAAGAACCTTTATAATTGAGGCAATGTAGTACCTATCTTTCCCATTAATT

>NZ_CP007647|1|1|216880-216994|CRISPRCasFinder
TTGAGGCAATGTAGTACCTATCTTTCCCATTAATT	ATTAAAATTTTGGCATCAGTCCTTTTTGACAAAGAACCTTTATAA
TTGAGGCAATGTAGTACCTATCTTTCCCATTAATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP007647.1\|WP_034982939.1\|212811_215178_+\|phosphoketolase-family-protein	unknown	unknown	gnl\|CDD\|235379
NZ_CP007647.1\|WP_044005752.1\|215499_216789_+\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|376574
NZ_CP007647.1\|WP_044005750.1\|204294_206286_-\|transketolase	unknown	unknown	gnl\|CDD\|223100
NZ_CP007647.1\|WP_003699362.1\|211887_212688_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP007647.1\|WP_034982935.1\|218526_218931_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP007647.1\|WP_034982942.1\|209624_210896_-\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_CP007647.1\|WP_044005751.1\|208561_209611_-\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_CP007647.1\|WP_034982945.1\|207465_208539_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176219
NZ_CP007647.1\|WP_034982940.1\|211253_211706_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129
NZ_CP007647.1\|WP_034982936.1\|217954_218473_-\|transposase	unknown	unknown	gnl\|CDD\|225511
NZ_CP007647.1\|WP_003703452.1\|206303_206957_-\|fructose-6-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234947
NZ_CP007647.1\|WP_034982941.1\|210922_211219_-\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908

Protein	Function_ID	Function_description	E-value
NZ_CP007647.1\|WP_034982945.1\|207465_208539_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176219	cd08258, Zn_ADH4, Alcohol dehydrogenases of the MDR family. This group shares the zinc coordination sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of an beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	2.54743e-147
NZ_CP007647.1\|WP_034982939.1\|212811_215178_+\|phosphoketolase-family-protein	gnl\|CDD\|235379	PRK05261, PRK05261, phosphoketolase.	0
NZ_CP007647.1\|WP_034982940.1\|211253_211706_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	2.62021e-31
NZ_CP007647.1\|WP_003699362.1\|211887_212688_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.79742e-72
NZ_CP007647.1\|WP_034982941.1\|210922_211219_-\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	5.16558e-35
NZ_CP007647.1\|WP_003703452.1\|206303_206957_-\|fructose-6-phosphate-aldolase	gnl\|CDD\|234947	PRK01362, PRK01362, fructose-6-phosphate aldolase.	9.35284e-140
NZ_CP007647.1\|WP_034982942.1\|209624_210896_-\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	7.81594e-167
NZ_CP007647.1\|WP_034982936.1\|217954_218473_-\|transposase	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	3.22357e-07
NZ_CP007647.1\|WP_044005751.1\|208561_209611_-\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	9.25653e-162
NZ_CP007647.1\|WP_044005752.1\|215499_216789_+\|ISL3-family-transposase	gnl\|CDD\|376574	pfam01610, DDE_Tnp_ISL3, Transposase. Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204, IS1001, IS1096 and IS1165.	3.4558e-71
NZ_CP007647.1\|WP_044005750.1\|204294_206286_-\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0

>NZ_CP007647.1|WP_044005752.1|215499_216789_+|ISL3-family-transposase
MDNNIKLLLGITDPNLTIDPKYQYTSYIEEKIIKNSKALLCHLYLSYPMYCPNCKTLMLHNGTKVVNNVHLSSTGKKLVLSIRKQKYLCPECKKTATAKFKDTNYHDHFSNAVKAKLVRDLSLSRPMCEIAADSFTSSNTIIRSLESVENNFKVNRNWLPSHLSLDDFKSGKRFSSSGMSMCLINVVNHRIIDIIPERNNKFLRNYFIQYSYKARLSVMTITVDLYAPYRSLIKELFPNAFIIADKFHVVTQAYTAMNKIRIRVMKEYGAGTHEYRALKRFWKLLLKNQDNVDYHRYYPRINFKYAELSDSEVLDRLFDMSSELKTAYEYYQLLLQMYRKNSCQLLNLLTDISSWNLPPEMRQALKTIKKHKAEIENSFVLPKLTNGPIEGVNNHIKVIKRIAYGYNNFKHFRLRILILLKNNLIFFST
>NZ_CP007647.1|WP_034982939.1|212811_215178_+|phosphoketolase-family-protein
MTINYSSKEYLELVDRYWRAADYVSVGQLYLKDNPLLDRPLVPTDVKVHPIGHWGTISGQNFIYAHLNRVINKYDLNMFYIEGPGHGGQVMVSNSYLDGSYTETYPEITQDKAGMQKLFKRFSFPGGVASHADPKTPGSIHEGGELGYSLLHGAGAILDNPNLIAATVIGDGEAETGPLATSWQVNKFINPINDGTVLPILDLNGFKISNPTVLSRMSHEELTSYFKGLGWNPHFVEGTDPKELHVKMADELDSIIEEIMAIRENAVKNNDESRPAWPMLVFRAPKGWGGPKEWDGDMIEGSFRAHQIPIPVDQNHTEHLDSLVSWLKSYKPEELFDEKGALLDDIKAIIPDKDHRMASNPVTNGGKLSKPLILPDPADFEFKTDHGTEDGSDMTELGKYIKAVFELNKDNKNFRGWGPDESLSNKLSAVFEETNRQWLEPIHEGSDALLAPHGRMIDSMLSEHMDEGMLEAYTLTGRHGFFASYESFLRVVDSMLTQHFKWLRNSHEETPWREDVPSLNIISTSTAFQQDHNGYSHQDPGIVTHLAEKKTKYIREYFPADANTLIAAFDKSLQTKQVINLIVASKHPRLQWYSAVEAKELVNNGLKIIDWASNVPEGEEPDVVFASAGSEPNLESLAAISILRKQAPSLKIRYVNVVDLLKLKKDDPRGLSDAEFDAYFTKDKPVIFAFHGYVDILKDIFFDRHNHNLHLHGYKEEGDITTPFDMRVRNELDRFHLVKDALEVVPGVSEKYATVLQDMDLLLQKHHDYIRSEGDDIEEVRTWKWDLD
>NZ_CP007647.1|WP_003699362.1|211887_212688_+|DeoR/GlpR-transcriptional-regulator
MDMLERHAEILKQVKEKGTVKISELSKELNTSRETIRKDIYILDKKQKLSSIRGGATFLKKGIEETRYGQRTVLDVIEKKEIAKLALNYIKDGNTIFLDYGTSVVELAKAIESSPLHDITVITNSLNVVDIFRYSTKNSLILLGGGLRSEEGSLSGPLTLTNIDNLYCNVGFFGCSGLSIQSGITNHYFSEVEVSKKMLSHSMNKVLLADHDKFNQIALYKTADVSELDVIITDKKTPLDIINKYKHIGIPVINSSSKIKLSTLKD
>NZ_CP007647.1|WP_034982940.1|211253_211706_-|PTS-sugar-transporter-subunit-IIA
MNIKDFLHDELIFTKTSFKNTTELFKEVAKIAEEKGYANSLFLEKIIKREETFPTGLQLENNGVAIPHTDADTIEKEFVAVITLENEGVPFKRMDDPNEEVEAKVVFVLGLNQPHQQLEMLQSLMAFIQDNKKLKQLETAQTVNDVKEVF
>NZ_CP007647.1|WP_034982941.1|210922_211219_-|PTS-sugar-transporter-subunit-IIB
MKKLNVLVACGAGIATSTVVMSKLEKLFEENNIDVELHQIKIAEAASKQKDADMLISTTILPTEYDIPAIKAMGFLTGIGVDKLQDEIIETAKKLQAE
>NZ_CP007647.1|WP_034982942.1|209624_210896_-|PTS-galactitol-transporter-subunit-IIC
MKVVGDVVQYILNMGASVMLPIMIFIIALIFRVKASKALRSALTIGIGMVGINLVINLLTTNIGPAAQAMVKRFGFHLTVIDVGWPSAAAGAWGQPISSILIPILLVTNLVLLITGITKTLDIDIWNYWHMVAAGSVAYIVTQSWIFSIISAILYMIFCLLIADWTAKDVQEFYGLEGISFPTGSSDAFGLLGIPISWVVSKIPGLGKIDVDAETIQKKFGIFGEPMMMGIIIGIVIGILAGYDVAGVLTLGINMGAVMMLMPRMVKLLMEGLMPISEAARELLQKRTGGKREILLGMDAALSTGAPATLAVGLLLVPITLFIAVILPGNKVLPFGDLATIPFYVSLIVARRRGNIINSVITGAIVITIALFMATNFTDVHTQMLEGVVKFPAGAAKVSSLDMGGNFLNWILLKLAEVWNAIF
>NZ_CP007647.1|WP_044005751.1|208561_209611_-|galactitol-1-phosphate-5-dehydrogenase
MKVAELVDLNKFNLVEKDLPTPSNNEVRVKVMAAGTCGSDSHKMKAGWKYGFPAVMGHEFSGIIDAVGGDVENIEVGERVAVAPFIPCFECEYCQSGMFQMCENYAMVGQTQPGGFEQYVCVPARNVLSIGNLSFTEGALIEPMAVAMHAVMGINPEIGDTAAVFGLGAIGDLVIRLLKAAGVVNIIGIDIDDKKLEKGLEEGCSYVINSVKESLEEKVAEYTNGQGVDITMECAGSKITEEQSLLITKRRGKVGFVGIAYSDVMLHKDAFENIFRHELTVKGFWNSYSAPFPGKEWTTSIKMVKNGSVKIKDLVTHKFELDEIQDAFNMIVSRSESYNKVMFYPNGIE
>NZ_CP007647.1|WP_034982945.1|207465_208539_-|zinc-binding-dehydrogenase
MNIPTKMKAVVKSEAGYDNMSLQEIPVPEVKGKQVLMKVAYTGICGTDIHTFKGEYANAVTPLVLGHEFSGKVVAVGDEVTKVKPGDRVTSETTFDTCGECVYCKNKEYNLCENRSGIGTKANGSMANYVLTREESVHVLPDNVSYKLAAMSEPLASCVHAMYQKTPFTLHDTVLIIGPGPMGLLSLQIAKEIGAFTIVSGITKDSDRLEIAKELGADIVVDTQKEDLAKIVMEATNGVGVTKVYDCSGATPAVNAALPLLKKGGTFQQVGLFAKPLNELDERTIIQHEITYVGSRSQNPYDWPIAIHLEAKGAINEDKMVTKVFDLDHWREAFEAMMAGKELKVLIASNPDDETLN
>NZ_CP007647.1|WP_003703452.1|206303_206957_-|fructose-6-phosphate-aldolase
MKFFLDTANTDDIRKYAELGLVDGVTTNPTIVAREGRNFESVIKEITTIVDGPVSAEVTANEADKMIEQARALAKWADNIVVKIPMTEAGLKAVSVLSKEGIKTNVTLVFSVAQGLMAAKAGATFISPFVGRLDDIGSDGVKLIKDLRTVLDNYGLKSEIIAASIRGVQHVEAVALAGSDIATIPAGVFGKMFKHPLTDNGLASFEKDWAEFEASQK
>NZ_CP007647.1|WP_044005750.1|204294_206286_-|transketolase
MYDQVDQLGVNTLRTLSIDAIQRANSGHPGLPMGAAPMAYVLWTRHLKINPKTHMNWVNRDRFVLSAGHGSALLYSLAHLAGYDVSMDDLKNFREWKSNTPGHPEYGCTDGVEATTGPLGQGISMAVGMAMAEAHLGKKFNREGYPVMDHYTYALIGDGDLMEGVASEAASLAGHLKLGKLIALYDSNGISLDGKTSASFTENVGARFEAYGWQYILVEDGFNLEEIDKAIVQAKAESDKPTIIEIKTTIGYGSENQGTHKVHGSPLGEEGVAHAKEVYNWNYPPFTVPEEVSQRFKECLQDKGVKAENKWNEMFEAYKKEYSDLAQKFSDGFSNKVPNTLGDILPQYGEDDSIATRAASQKAINALAKEVSSLWGGAADLASSNKTVIAGEGDFQPESYEGRNIWFGVREFGMACAMNGIMLHGGTRVFGSTFFVFSDYLKAAIRLSAIQKLPVIYVLTHDSVAVGKDGPTHEPIEQLASLRTIPNVQVFRPADGNETSAAWKVALETLDKPTILVLSRQNLDTLPISKEKVFDGVEKGGYVVQGAENEADGILIATGSEVGLALKAKEELQKKGKDVSVVSLPSWERFEAQSEEYKNTVIPPELKKRMTIEAGTTYGWAKYAGDHGVMIGIDEFGMSAPSDIVLRELGMSVENIVDKYLEK
>NZ_CP007647.1|WP_034982936.1|217954_218473_-|transposase
MTKYTQKFKLDLIQEYLDTGCSQRCLENKYSLPKDTLKKWWTVYNLKGPEGLKLRHFKRKFTVDFKLRVINYYLNNDVSMSKVAASHNLLCSQISIWLKLFMEGGSEALKPKKKGKPSKMSKMTKKDVRKILKKESDEIAALKSELRQVKMERDILKKSLALFGPSKPRRKQ
>NZ_CP007647.1|WP_034982935.1|218526_218931_-|hypothetical-protein
MTAESIISMLKEISDNGNKKYPVTDFGGVFIFRITFFDKIPNDVANKLIDLNLPDEVIELLSCTNGLNLFEDEFQGMELGGSVCKIYSGQEILNRYQESIDKDLIPILLFRDYGEMCINIRHYKQEKDYLTYPG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NZ_CP007646.1	1626085-1626129	1	0.978
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NZ_CP007646.1	1358706-1358750	2	0.956

1. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to position: 1626085-1626129, mismatch: 1, identity: 0.978

attaaaattttggcatcagtcctttttgacaaagaacctttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaacctttaaaa	Protospacer
****************************************** **

2. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to position: 1358706-1358750, mismatch: 2, identity: 0.956

attaaaattttggcatcagtcctttttgacaaagaacctttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaacccatataa	Protospacer
**************************************. *****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NZ_CP007647	Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence	216915-216959	0	1.0
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NZ_CP007647	Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence	216835-216879	1	0.978
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NZ_CP007647	Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence	68306-68350	4	0.911
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NZ_CP007647	Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence	202716-202760	4	0.911
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NZ_CP007647	Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence	13493-13537	4	0.911
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NZ_CP007647	Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence	164028-164072	4	0.911
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NZ_CP020859	Lactobacillus salivarius strain ZLS006 plasmid unnamed1, complete sequence	69581-69625	4	0.911
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NZ_CP020859	Lactobacillus salivarius strain ZLS006 plasmid unnamed1, complete sequence	138981-139025	4	0.911
NZ_CP007647_1	1.1\|216915\|45\|NZ_CP007647\|CRISPRCasFinder	216915-216959	45	NC_007930	Lactobacillus salivarius UCC118 plasmid pMP118, complete sequence	165030-165074	4	0.911

1. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to NZ_CP007647 (Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence) position: , mismatch: 0, identity: 1.0

attaaaattttggcatcagtcctttttgacaaagaacctttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaacctttataa	Protospacer
*********************************************

2. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to NZ_CP007647 (Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence) position: , mismatch: 1, identity: 0.978

attaaaattttggcatcagtcctttttgacaaagaacctttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaacctttatat	Protospacer
********************************************

3. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to NZ_CP007647 (Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence) position: , mismatch: 4, identity: 0.911

attaaaattttggcatcagtcctttttgacaaagaacctttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaaccctttttt	Protospacer
**************************************.** *

4. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to NZ_CP007647 (Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence) position: , mismatch: 4, identity: 0.911

attaaaattttggcatcagtcctttttgacaaagaacctttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaacctagaaat	Protospacer
***************************************  * *

5. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to NZ_CP007647 (Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence) position: , mismatch: 4, identity: 0.911

attaaaattttggcatcagtcctttttgacaaagaacc----tttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaaccagctttt----	Protospacer
**************************************    ***

6. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to NZ_CP007647 (Lactobacillus salivarius strain JCM1046 plasmid pMP1046A, complete sequence) position: , mismatch: 4, identity: 0.911

attaaaattttggcatcagtcctttttgacaaagaacc----tttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaaccaagtttt----	Protospacer
**************************************    ***

7. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to NZ_CP020859 (Lactobacillus salivarius strain ZLS006 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.911

attaaaattttggcatcagtcctttttgacaaagaacctttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaaccaaactaa	Protospacer
**************************************    ***

8. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to NZ_CP020859 (Lactobacillus salivarius strain ZLS006 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.911

attaaaattttggcatcagtcctttttgacaaagaacctttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaaccaaaaaaa	Protospacer
**************************************   * **

9. spacer 1.1|216915|45|NZ_CP007647|CRISPRCasFinder matches to NC_007930 (Lactobacillus salivarius UCC118 plasmid pMP118, complete sequence) position: , mismatch: 4, identity: 0.911

attaaaattttggcatcagtcctttttgacaaagaacc----tttataa	CRISPR spacer
attaaaattttggcatcagtcctttttgacaaagaaccaaatttt----	Protospacer
**************************************    ***

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

5301 : 14446

Enterococcus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003699336.1\|5301_6114_+	AAA family ATPase	F0PIG8	Enterococcus_phage	8.6e-85	61.0
WP_003699335.1\|6113_6449_+	DUF5388 domain-containing protein	F0PIG7	Enterococcus_phage	1.3e-07	34.2
WP_034983710.1\|6908_8126_+\|transposase	transposase	A0A0P0IJS6	Lactobacillus_phage	3.3e-120	55.3
WP_034983803.1\|8746_11281_-	M1 family metallopeptidase	A0A0P0IY26	Acinetobacter_phage	3.3e-66	26.5
WP_044005673.1\|12158_13448_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	8.1e-45	30.0
WP_044005674.1\|13591_14446_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	4.5e-52	39.9

DBSCAN-SWA_2

71391 : 82550

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080739395.1\|71391_72234_+	DegV family protein	A0A1X9I5J4	Streptococcus_phage	5.5e-42	35.0
WP_044005705.1\|72421_72856_+	N-acetyltransferase	A0A1X9I6I8	Streptococcus_phage	3.1e-33	50.0
WP_003699254.1\|73948_74224_-	HU family DNA-binding protein	A0A0H3UZA0	Geobacillus_virus	4.1e-23	62.9
WP_044005706.1\|74528_79121_+	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	5.2e-17	31.2
WP_003703258.1\|79249_79609_+	hypothetical protein	NA	NA	NA	NA
WP_003706971.1\|79624_80437_+	SPFH domain-containing protein	S4VT23	Pandoravirus	1.1e-15	29.7
WP_034983646.1\|80771_81467_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_003706982.1\|81977_82550_+	DNA starvation/stationary phase protection protein	A0A0A7RTZ1	Clostridium_phage	3.9e-23	42.6

DBSCAN-SWA_3

119030 : 178577

Paramecium_bursaria_Chlorella_virus(20.0%)

capsid,bacteriocin,transposase,integrase

attL 144970:144986|attR 181456:181472

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_044005722.1\|119030_120428_+\|transposase	ISLre2 family transposase	NA	NA	NA	NA
WP_034982226.1\|121123_121348_+	hypothetical protein	NA	NA	NA	NA
WP_032494132.1\|121439_122414_+	choloylglycine hydrolase family protein	M1HWD6	Paramecium_bursaria_Chlorella_virus	8.6e-23	31.8
WP_044005723.1\|122535_123333_-	tyrosine-protein phosphatase	NA	NA	NA	NA
WP_044005724.1\|123405_124011_-	response regulator transcription factor	NA	NA	NA	NA
WP_044005725.1\|124013_125123_-	sensor histidine kinase	NA	NA	NA	NA
WP_034982221.1\|125131_125872_-	ABC transporter permease	NA	NA	NA	NA
WP_044005726.1\|125874_126750_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.4e-19	28.7
WP_044005727.1\|126986_127670_+	ribose-5-phosphate isomerase RpiA	NA	NA	NA	NA
WP_034982218.1\|127686_128334_+	ribulose-phosphate 3-epimerase	NA	NA	NA	NA
WP_034982250.1\|128403_128928_+	hypothetical protein	NA	NA	NA	NA
WP_003702995.1\|129435_129738_+	hypothetical protein	NA	NA	NA	NA
WP_034982162.1\|129995_130874_+	patatin family protein	NA	NA	NA	NA
WP_003708477.1\|130959_131796_-	pyruvate formate lyase-activating protein	NA	NA	NA	NA
WP_044005728.1\|131822_134090_-	formate C-acetyltransferase	A0A2P0VNR5	Tetraselmis_virus	2.8e-173	42.2
WP_080739397.1\|134401_134986_-	VIT1/CCC1 transporter family protein	NA	NA	NA	NA
WP_174633258.1\|135178_136603_-	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
WP_003706789.1\|136574_137024_-	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
WP_034982157.1\|137020_138247_-	cysteine desulfurase	Q2XUY6	environmental_halophage	2.4e-110	47.6
WP_034982156.1\|138230_139484_-	Fe-S cluster assembly protein SufD	NA	NA	NA	NA
WP_034982154.1\|139496_140276_-	Fe-S cluster assembly ATPase SufC	A0A285PWH2	Cedratvirus	1.3e-08	28.3
WP_044005729.1\|140537_142172_-	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_044005762.1\|142625_143783_-	chloride transporter	NA	NA	NA	NA
WP_044005730.1\|143976_144249_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
144970:144986	attL	NA	NA	NA	NA
WP_004564415.1\|145088_146138_-	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_044005731.1\|146344_147340_+	D-2-hydroxyacid dehydrogenase	M1H502	Paramecium_bursaria_Chlorella_virus	1.1e-44	38.4
WP_044005732.1\|147400_148081_-	fructose-6-phosphate aldolase	A0A0E3EPH4	Synechococcus_phage	1.5e-21	30.9
WP_044005733.1\|148147_148528_-	PTS glucitol/sorbitol transporter subunit IIA	NA	NA	NA	NA
WP_044005734.1\|148564_149590_-	PTS glucitol/sorbitol transporter subunit IIB	NA	NA	NA	NA
WP_003699442.1\|149606_150149_-	PTS glucitol/sorbitol transporter subunit IIC	NA	NA	NA	NA
WP_003699440.1\|150160_150658_-	transcriptional regulator GutM	NA	NA	NA	NA
WP_044005735.1\|150658_152518_-	HTH domain-containing protein	NA	NA	NA	NA
WP_044005736.1\|152533_153337_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_044005737.1\|153638_154001_-	hypothetical protein	A0A1S5RCP6	Lactobacillus_phage	1.1e-10	44.9
WP_080739399.1\|155017_155866_-\|capsid	minor capsid protein	U3PFU0	Lactobacillus_phage	1.7e-30	46.4
WP_044005739.1\|155966_156863_-	nitronate monooxygenase	NA	NA	NA	NA
WP_034982116.1\|156965_159623_-	bifunctional acetaldehyde-CoA/alcohol dehydrogenase	NA	NA	NA	NA
WP_044005740.1\|162693_163983_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	3.6e-45	30.0
WP_044005741.1\|164400_166371_-	fructose-bisphosphatase class III	NA	NA	NA	NA
WP_034983677.1\|166715_167537_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_148305456.1\|168342_169011_-	hypothetical protein	NA	NA	NA	NA
WP_044005743.1\|169086_169419_-	hypothetical protein	NA	NA	NA	NA
WP_143453799.1\|169423_169921_-	hypothetical protein	NA	NA	NA	NA
WP_034983622.1\|170397_170802_-	PIN domain-containing protein	NA	NA	NA	NA
WP_034983620.1\|170801_171023_-	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_044005744.1\|171465_172614_-	HlyD family efflux transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_034983617.1\|174998_175196_-	hypothetical protein	NA	NA	NA	NA
WP_034983616.1\|175440_175680_-	hypothetical protein	NA	NA	NA	NA
WP_034983615.1\|175716_176511_-	response regulator transcription factor	NA	NA	NA	NA
WP_034983613.1\|176524_177817_-	GHKL domain-containing protein	NA	NA	NA	NA
WP_034983611.1\|177818_177938_-\|bacteriocin	bacteriocin	NA	NA	NA	NA
WP_034983610.1\|178370_178577_-\|bacteriocin	Blp family class II bacteriocin	NA	NA	NA	NA
181456:181472	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP007648

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP007650

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP007646

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

4. NZ_CP007647

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection