CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP008810	Campylobacter fetus subsp. venerealis 97/608	2 crisprs	cas4,c2c9_V-U4,cas14j,DEDDh,cas6,csx23,cas10,csm3gr7,csx10gr5,csx19	2	4	3
NZ_CP008812	Campylobacter fetus subsp. venerealis 97/608 plasmid pCFV97608-2, complete sequence	0 crisprs	c2c9_V-U4,cas14j	0	0	3
NZ_CP008811	Campylobacter fetus subsp. venerealis 97/608 plasmid pCFV97608-1, complete sequence	0 crisprs	c2c9_V-U4,cas14j	0	0	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP008810_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP008810_1

688725-690400

Orphan

Consensus_repeat	Method
GTTTGCTAATGACAATGTTTGTGTTGAAAC	PILER-CR
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CRISPRCasFinder
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CRT

25 spacers

The CRISPR arrays of NZ_CP008810_1

>merge|NZ_CP008810|1|688725-690400|PILER-CR,CRISPRCasFinder,CRT
GTTTGCTAATGACAATGTTTGTGTTGAAACCCGTAAGCTACATTGTAAGCTAAGTCTTCAAAGACTGTTTGCTAATGACAATGTTTGTGTTGAAACTATAAAGGGACCTACGAACTAAGCTAGAACCCTTTTGTTTGCTAATGACAATGTTTGTGTTGAAACGTGTAAGCAAGATGGCAAGAGACTATCTCCTGTTGTGTTTGCTAATGACAATGTTTGTGTTGAAACCGGGGAGCAACGTTAGCAATCTCATTTCCGTCCATGTTTGCTAATGACAATGTTTGTGTTGAAACTGGGGATTCGATGAAATTTTTAACTATATAGCATTCGTTTGCTAATGACAATGTTTGTGTTGAAACTTTTTATAAGGCTCATTTTTGAAGATATTATGCTGCGTTTGCTAATGACAATGTTTGTGTTGAAACCGGGGAGCAACGTTAGCAATCTCATTTCCGTCCATGTTTGCTAATGACAATGTTTGTGTTGAAACTGGGGATTCGATGAAATTTTTAACTATATAGCATTCGTTTGCTAATGACAATGTTTGTGTTGAAACTTTTTATAAGGCTCATTTTTGAAGATATTATGCTGCGTTTGCTAATGACAATGTTTGTGTTGAAACTCCAGAGCTAATAAGGGATTTAGAGCAGCTAAAAACTGTTTGCTAATGACAATGTTTGTGTTGAAACCGCAAAAAGAGTTGAAATATATAGATAATAGGTTAAGTTTGCTAATGACAATGTTTGTGTTGAAACAATCCAACTTAACAAAAATGTTATATAAAATCACCGTTTGCTAATGACAATGTTTGTGTTGAAACTAAACTATTTCGTTATCCTGGTTGATACCGCTTAAAGTTTGCTAATGACAATGTTTGTGTTGAAACATGAGTTTAAATTTGATAGATCTGAAAAGATTATTCGTTTGCTAATGACAATGTTTGTGTTGAAACCTTGATACTTTTTGCTTGATTAGCTTTGCATTTTTAGTTTGCTAATGACAATGTTTGTGTTGAAACTCCCCGTTATCTACCTCTGGCGCCATGCTCTCTCCGGTTTGCTAATGACAATGTTTGTGTTGAAACCCTTCTGCGATATATTTGATGAAAAAACAGAAAGGGTTTGCTAATGACAATGTTTGTGTTGAAACTTTGAAGTGCACGACGCTATAACTAGAACACGGATCGTTTGCTAATGACAATGTTTGTGTTGAAACATTAAAGCCGAATTACTCCCATTTTTTTTGACTTGGGTTTGCTAATGACAATGTTTGTGTTGAAACTGTATGTTGGTAGCTTTTATGGTTACTTTACATAACGTTTGCTAATGACAATGTTTGTGTTGAAACAATCCAACTTAACAAAAATGTTATATAAAATCACCGTTTGCTAATGACAATGTTTGTGTTGAAACTAAGCAAGGCTTATAAGCTCTTTACAATGCATTTTTGTTTGCTAATGACAATGTTTGTGTTGAAACAGAACTGTTTTAACCTCACTTCCATCAATCTCTTTTGTTTGCTAATGACAATGTTTGTGTTTAAACCAGTATGCCATTTGATTCTAGTTCGCCTATAGCTCTGTTTGCTAATGACAATGTTTGTGTTGAAACCATCCTCCTTTTAATTTATTACATTTAAACAATTTAGTTTGCTAATGACAATGTTTGTGTTGAAAC

>NZ_CP008810|1|1|688725-690400|PILER-CR
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CCGTAAGCTACATTGTAAGCTAAGTCTTCAAAGACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TATAAAGGGACCTACGAACTAAGCTAGAACCCTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	GTGTAAGCAAGATGGCAAGAGACTATCTCCTGTTGT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TCCAGAGCTAATAAGGGATTTAGAGCAGCTAAAAACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CGCAAAAAGAGTTGAAATATATAGATAATAGGTTAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC	AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TAAACTATTTCGTTATCCTGGTTGATACCGCTTAAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC	ATGAGTTTAAATTTGATAGATCTGAAAAGATTATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CTTGATACTTTTTGCTTGATTAGCTTTGCATTTTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TCCCCGTTATCTACCTCTGGCGCCATGCTCTCTCCG
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CCTTCTGCGATATATTTGATGAAAAAACAGAAAGG
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TTTGAAGTGCACGACGCTATAACTAGAACACGGATC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	ATTAAAGCCGAATTACTCCCATTTTTTTTGACTTGG
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TGTATGTTGGTAGCTTTTATGGTTACTTTACATAAC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TAAGCAAGGCTTATAAGCTCTTTACAATGCATTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	AGAACTGTTTTAACCTCACTTCCATCAATCTCTTTT
GTTTGCTAATGACAATGTTTGTGTTTAAAC	CAGTATGCCATTTGATTCTAGTTCGCCTATAGCTCT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CATCCTCCTTTTAATTTATTACATTTAAACAATTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC

>NZ_CP008810|1|1|688725-690400|CRISPRCasFinder
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CCGTAAGCTACATTGTAAGCTAAGTCTTCAAAGACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TATAAAGGGACCTACGAACTAAGCTAGAACCCTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	GTGTAAGCAAGATGGCAAGAGACTATCTCCTGTTGT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TCCAGAGCTAATAAGGGATTTAGAGCAGCTAAAAACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CGCAAAAAGAGTTGAAATATATAGATAATAGGTTAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC	AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TAAACTATTTCGTTATCCTGGTTGATACCGCTTAAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC	ATGAGTTTAAATTTGATAGATCTGAAAAGATTATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CTTGATACTTTTTGCTTGATTAGCTTTGCATTTTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TCCCCGTTATCTACCTCTGGCGCCATGCTCTCTCCG
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CCTTCTGCGATATATTTGATGAAAAAACAGAAAGG
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TTTGAAGTGCACGACGCTATAACTAGAACACGGATC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	ATTAAAGCCGAATTACTCCCATTTTTTTTGACTTGG
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TGTATGTTGGTAGCTTTTATGGTTACTTTACATAAC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TAAGCAAGGCTTATAAGCTCTTTACAATGCATTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	AGAACTGTTTTAACCTCACTTCCATCAATCTCTTTT
GTTTGCTAATGACAATGTTTGTGTTTAAAC	CAGTATGCCATTTGATTCTAGTTCGCCTATAGCTCT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CATCCTCCTTTTAATTTATTACATTTAAACAATTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC

>NZ_CP008810|1|1|688725-690400|CRT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CCGTAAGCTACATTGTAAGCTAAGTCTTCAAAGACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TATAAAGGGACCTACGAACTAAGCTAGAACCCTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	GTGTAAGCAAGATGGCAAGAGACTATCTCCTGTTGT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CGGGGAGCAACGTTAGCAATCTCATTTCCGTCCAT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TGGGGATTCGATGAAATTTTTAACTATATAGCATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TTTTTATAAGGCTCATTTTTGAAGATATTATGCTGC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TCCAGAGCTAATAAGGGATTTAGAGCAGCTAAAAACT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CGCAAAAAGAGTTGAAATATATAGATAATAGGTTAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC	AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TAAACTATTTCGTTATCCTGGTTGATACCGCTTAAA
GTTTGCTAATGACAATGTTTGTGTTGAAAC	ATGAGTTTAAATTTGATAGATCTGAAAAGATTATTC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CTTGATACTTTTTGCTTGATTAGCTTTGCATTTTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TCCCCGTTATCTACCTCTGGCGCCATGCTCTCTCCG
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CCTTCTGCGATATATTTGATGAAAAAACAGAAAGG
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TTTGAAGTGCACGACGCTATAACTAGAACACGGATC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	ATTAAAGCCGAATTACTCCCATTTTTTTTGACTTGG
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TGTATGTTGGTAGCTTTTATGGTTACTTTACATAAC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	AATCCAACTTAACAAAAATGTTATATAAAATCACC
GTTTGCTAATGACAATGTTTGTGTTGAAAC	TAAGCAAGGCTTATAAGCTCTTTACAATGCATTTTT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	AGAACTGTTTTAACCTCACTTCCATCAATCTCTTTT
GTTTGCTAATGACAATGTTTGTGTTTAAAC	CAGTATGCCATTTGATTCTAGTTCGCCTATAGCTCT
GTTTGCTAATGACAATGTTTGTGTTGAAAC	CATCCTCCTTTTAATTTATTACATTTAAACAATTTA
GTTTGCTAATGACAATGTTTGTGTTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP008810.1\|WP_002849050.1\|686153_686930_+\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_CP008810.1\|WP_025370330.1\|690410_691178_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213641
NZ_CP008810.1\|WP_002849060.1\|691511_691718_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008810.1\|WP_024305374.1\|681906_683829_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP008810.1\|WP_046037358.1\|698153_699635_+\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|223383
NZ_CP008810.1\|WP_011731911.1\|696325_697099_+\|pyridoxine-5'-phosphate-synthase	unknown	unknown	gnl\|CDD\|235380
NZ_CP008810.1\|WP_002849039.1\|678136_679480_+\|3-deoxy-7-phosphoheptulonate-synthase-class-II	unknown	unknown	gnl\|CDD\|366662
NZ_CP008810.1\|WP_011731891.1\|687432_688170_+\|YaaA-family-protein	unknown	unknown	gnl\|CDD\|377151
NZ_CP008810.1\|WP_002849081.1\|697095_698019_+\|4-hydroxythreonine-4-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|179681
NZ_CP008810.1\|WP_002849067.1\|691153_691471_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008810.1\|WP_002849077.1\|694683_695400_+\|arginyltransferase	unknown	unknown	gnl\|CDD\|234939
NZ_CP008810.1\|WP_002849042.1\|679641_680865_-\|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143398
NZ_CP008810.1\|WP_038452375.1\|693008_694454_+\|acetyl-CoA-carboxylase-subunit-A	unknown	unknown	gnl\|CDD\|169452
NZ_CP008810.1\|WP_002849052.1\|686929_687436_+\|HIT-domain-containing-protein	unknown	unknown	gnl\|CDD\|238606
NZ_CP008810.1\|WP_002849076.1\|694460_694697_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008810.1\|WP_011731910.1\|695456_696281_+\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|236352
NZ_CP008810.1\|WP_010403934.1\|683825_684521_+\|methyltransferase	unknown	unknown	gnl\|CDD\|226608
NZ_CP008810.1\|WP_002849046.1\|684514_684886_+\|YkgJ-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|223799
NZ_CP008810.1\|WP_024305373.1\|684861_686157_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP008810.1\|WP_002849044.1\|680943_681897_+\|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|379355

Protein	Function_ID	Function_description	E-value
NZ_CP008810.1\|WP_002849050.1\|686153_686930_+\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	6.08927e-122
NZ_CP008810.1\|WP_025370330.1\|690410_691178_+\|hypothetical-protein	gnl\|CDD\|213641	TIGR01641, Uncharacterized_protein_MJ0329, phage putative head morphogenesis protein, SPP1 gp7 family. This model describes a region of about 110 amino acids found exclusively in phage-related proteins, internally or toward the C-terminus. One member, gp7 of phage SPP1, appears involved in head morphogenesis. [Mobile and extrachromosomal element functions, Prophage functions].	0.000442902
NZ_CP008810.1\|WP_011731910.1\|695456_696281_+\|adenylosuccinate-lyase	gnl\|CDD\|236352	PRK08937, PRK08937, adenylosuccinate lyase; Provisional.	2.29446e-18
NZ_CP008810.1\|WP_024305374.1\|681906_683829_+\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	9.18393e-08
NZ_CP008810.1\|WP_046037358.1\|698153_699635_+\|inorganic-phosphate-transporter	gnl\|CDD\|223383	COG0306, PitA, Phosphate/sulphate permeases [Inorganic ion transport and metabolism].	1.16118e-49
NZ_CP008810.1\|WP_011731911.1\|696325_697099_+\|pyridoxine-5'-phosphate-synthase	gnl\|CDD\|235380	PRK05265, PRK05265, pyridoxine 5'-phosphate synthase; Provisional.	9.13382e-114
NZ_CP008810.1\|WP_002849039.1\|678136_679480_+\|3-deoxy-7-phosphoheptulonate-synthase-class-II	gnl\|CDD\|366662	pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.	0
NZ_CP008810.1\|WP_011731891.1\|687432_688170_+\|YaaA-family-protein	gnl\|CDD\|377151	pfam03883, H2O2_YaaD, Peroxide stress protein YaaA. YaaA is a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause. The molecular mechanism of action is not known.	3.02596e-45
NZ_CP008810.1\|WP_002849081.1\|697095_698019_+\|4-hydroxythreonine-4-phosphate-dehydrogenase	gnl\|CDD\|179681	PRK03946, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional.	0
NZ_CP008810.1\|WP_002849077.1\|694683_695400_+\|arginyltransferase	gnl\|CDD\|234939	PRK01305, PRK01305, arginyl-tRNA-protein transferase; Provisional.	7.00248e-89
NZ_CP008810.1\|WP_002849042.1\|679641_680865_-\|glutamate-5-semialdehyde-dehydrogenase	gnl\|CDD\|143398	cd07079, ALDH_F18-19_ProA-GPR, Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19. Gamma-glutamyl phosphate reductase (GPR), a L-proline biosynthetic pathway (PBP) enzyme that catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The glutamate route of the PBP involves two enzymatic steps catalyzed by gamma-glutamyl kinase (GK, EC 2.7.2.11) and GPR (EC 1.2.1.41). These enzymes are fused into the bifunctional enzyme, ProA or delta(1)-pyrroline-5-carboxylate synthetase (P5CS) in plants and animals, whereas they are separate enzymes in bacteria and yeast. In humans, the P5CS (ALDH18A1), an inner mitochondrial membrane enzyme, is essential to the de novo synthesis of the amino acids proline and arginine. Tomato (Lycopersicon esculentum) has both the prokaryotic-like polycistronic operons encoding GK and GPR (PRO1, ALDH19) and the full-length, bifunctional P5CS (PRO2, ALDH18B1).	0
NZ_CP008810.1\|WP_038452375.1\|693008_694454_+\|acetyl-CoA-carboxylase-subunit-A	gnl\|CDD\|169452	PRK08463, PRK08463, acetyl-CoA carboxylase subunit A; Validated.	0
NZ_CP008810.1\|WP_002849052.1\|686929_687436_+\|HIT-domain-containing-protein	gnl\|CDD\|238606	cd01275, FHIT, FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.	3.923e-47
NZ_CP008810.1\|WP_010403934.1\|683825_684521_+\|methyltransferase	gnl\|CDD\|226608	COG4123, COG4123, Predicted O-methyltransferase [General function prediction only].	5.72991e-53
NZ_CP008810.1\|WP_002849046.1\|684514_684886_+\|YkgJ-family-cysteine-cluster-protein	gnl\|CDD\|223799	COG0727, COG0727, Predicted Fe-S-cluster oxidoreductase [General function prediction only].	1.65843e-13
NZ_CP008810.1\|WP_024305373.1\|684861_686157_+\|hypothetical-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	9.35572e-08
NZ_CP008810.1\|WP_002849044.1\|680943_681897_+\|NAD(P)-binding-domain-containing-protein	gnl\|CDD\|379355	pfam13738, Pyr_redox_3, Pyridine nucleotide-disulphide oxidoreductase.	1.83609e-57

>NZ_CP008810.1|WP_011731891.1|687432_688170_+|YaaA-family-protein
MKILFSPSESKMSGGSRDASVNFSWVFPNLNDKRLEILEMYNSFLKKANKNELQALFGLKKDNELEYYSSDLFSRPLMKAILRYNGVAYEHLNYRNLDERSRKMIDENTIIFSNLYGVILAKDMIFDYKLKQGESIGGFRTEVFYKKYFSGVLDDFLDSDILDLRAGFYEKFYSLTKPYTTIKFLKNGKVVSHFAKAYRGIVLRCIALNQISSLDEFYNMQIPNLKINKIIKNRLKTEIVVDIIG
>NZ_CP008810.1|WP_002849052.1|686929_687436_+|HIT-domain-containing-protein
MEHEFSPWRAEYFKTRKDDGVTDHSCVFCDIAENIQNDEENFVLFRAKNCFAVMNRYPYTLGEFMIIPYIHTDNIENLDKNIWSEMSDLVQLGVGVLKESLNANGVNIGMNLGSAAGAGIAEHIHYHLVPRWSRDTNFITTIAYTRVHGVPFLDQYHTLKKAFQKIFK
>NZ_CP008810.1|WP_002849050.1|686153_686930_+|indole-3-glycerol-phosphate-synthase-TrpC
MILDEIISKTKINLENIKENLPLCRLENALTNSYIPRDVKQVLKQKNSINIIAEIKKASPSKGVIKEDFDPLKIAFEYEKAGVSAFSILTEPFYFQGSLEYIALVRRYTNTPILRKDFIVDIYQIAEARLYGADFILLIAKALDKFYLKTLFEYAKSLNLEVLMEIHDETDLEKALFVDADIIGINHRNLQTFDMDMELCIKLIPLIPSGKIIVAESGLYNNSELINLKKQGADAFLIGEHFMRQESIYNAVKDMKGE
>NZ_CP008810.1|WP_024305373.1|684861_686157_+|hypothetical-protein
MYWCRAALIFTLFLAGCADKQSVGAKKNETFFKYSDINTTIDLEAMKGFYLLGDAKSKDALEVFYMLYKTTKKPIFLKEALKIAFVIKDDRLDELITDAREILNADYDVIRIEIGYYILKSQIKDAKDLALNLIQKESDNSINHSILATIYLFNDEPIRALKEFKKAYEIEGSEENLLKLVDMLDNKLDRTNEAIRYLNNWIGENGCSKPVCFTLLNIYSAKGELDLMIEVYIKLYEAYEESDFLNRALEILLYKKDVISAKELLEKYSFNEPILMEIYAELKEFQKAYNVAQDLYNRSQNPEYMARMAIYKYEQSSKNISKFELDMVVKLFEGSVYALNSPIYFNYYGYLLIDYEIDLKKGLDIAKKAYILDPNSPYIIDSIAWGYFKLGECKEAKMWMDKIQSDTKFMKEDEAKAHKTAIDKCFNKGTK
>NZ_CP008810.1|WP_002849046.1|684514_684886_+|YkgJ-family-cysteine-cluster-protein
MLKEFGFDYCFDSSKCEVCGAKCCTGDSGYIWISEAEMESLSSHLKLSLPEFKKLFTYRVGVRFSLKEKEYNGAYACLFFDENNKNCSVYEFRPKQCRTFPFWDYFKKHFNELEKECIGVERL
>NZ_CP008810.1|WP_010403934.1|683825_684521_+|methyltransferase
MKLFQLKEGYRYNSDTLFLYDFISKNQIFGNVLDVGCGCGILGLLLKRDFINLNLSSIDIQEINSTITQLNADVNNLVAAVICDDFSKFKSEIKFDFIVSNPPFYNSQITKSENEHISISRYSSSLDPLSFFKSVNANLKPQGVLYFCYDARRVGEILPILSSLKLKLTKLRFVHSRISESSKLALFEAKKSSKSICGIYPPLIIFDENEFSGEVKEIFKKSDTKSEIYEC
>NZ_CP008810.1|WP_024305374.1|681906_683829_+|hypothetical-protein
MKFRKFAQILFLVGTIFFILGCETKDEKALNQDKLKFSDLSMAEQDRYISKDELDKLGSYLTLLNNRNIDINSDEIPSGSVDELRDKIAELIQKNRLLFADNEELAKKNLEIITKLREQNSLRESENKLISAKYLDSMNEVEKQHYKNINDLTKKINEVQKENIQSIKSYEQKIIGLENKIDELEKELSKKDINFNEKVSSATKDQLEKNKELSQKNSYLLEQTQVLKKQVDTLSKELDSKLADKKTQIDTLNQTILTKDNKINDLLASHTNEIIELQNKHSKALYDIKNELDRQKNDYFGELNLKNSELAKLNNDFKEYKLKKDEELKNAENRVLINYKKIETQRLNAIKSDYERIIFEQNRTIAAFEGKMINLELKFKKDLEAKDANYVNTLENLKQKALFLKNDEDRLRAEFDKNITSLKSQITLKNIQISELDSKIKELENEKNDIKKIQNYEILNNMITKLNAQNEELKNYAKKALDEAKKMVLEAENKAKEQNDKLKNYYEELIKNIKNQDNQPVLSDINVDSKRFLSEISCLSLDKSAKLDKDCENKLNDMIKKYGKSRIYEIKAVISDFKFLGDDKVGELKNVNLLNLKSTKDMLNAASKAINSKIKDPMLAYSKDVLLEQSGYGFVIKVYE
>NZ_CP008810.1|WP_002849044.1|680943_681897_+|NAD(P)-binding-domain-containing-protein
MENIYDVVVIGGGPFGIATVVEAKYNGFKNVLLLEKGDNHSQTIRKFYKDGKRVDKVYKGLDSQTHGNVEFFDGTKESTLNYFDNLLDNGKIDAVFNIEVESVKKDGDIFNIVTSKNTYKSKNVMIGIGRMGKPNKPEYKIPPSLTQIVNFNLNSCNCGENILVIGGGNSAAEYAIELSKCNTVTLCYRKEKFTRLNEINEAQVFEYFNDKKLNLKLGIDVIGLDNENGKVKVNFSNNSSEIYDRIIYAIGGSTPVDFLQKCGIELNKDGEPIVDEHLQTNTPRLFVGGDIASKNGGSIVVALNDAHTVIDYIIKSK
>NZ_CP008810.1|WP_002849042.1|679641_680865_-|glutamate-5-semialdehyde-dehydrogenase
MEKLLNNLKNSSKSLSILTQTQRENLIINIANEIMSAKDEILSANKIDLDLAQDLSSALKDRLKLTSKSIENLCNSIKNIANLKDVIGVIKDGWQTKSGLKIEKITIPLGNIATIYESRPNVTAEVAALCIKSANGCALKGGKEAKNTNLAIIKAIHKALQKCGLDKNCVVYLDIDRNEVKKLINMDKYLDLIVPRGGENLVKFVSQNATIPVLKHDKGLCHIYVDEFADLDKALSICVNAKCSRPGVCNAAETILVHEEVANEFIPNLKKSLDEFNVIIFGCKKTAKIIDCELANEQNYSTEYLDFKLNLKIVKNLEESLEHISEFSSGHSEAVISESYSICERFLSLVDSACVYANASTRFSDGGEFGFGAEIGISTNKLHARGPVGLNELTTYKYIIRANGQIR
>NZ_CP008810.1|WP_002849039.1|678136_679480_+|3-deoxy-7-phosphoheptulonate-synthase-class-II
MSKWNRDSWRDYNILQQPHYPDKNELKNAEDKLKSLPPLVFAGEVRNLKDELKNVTLGKSFLLQGGDCAESFSNFSANGIRDMFKIMLQMAIVLTFAGGCPVVKVGRVAGQFAKPRSSDFEDIDGVKLPSYRGDIINGFDFTEEARIPDPKRMIDAYYQSASTLNLLRAFSRGGLANLNEVHRWNLGFIKKAELDNKFEKLADELTGALKFMEACGVTTQNTPTLSETKLYTSHEALLLPYEEALTRVDSLTNEWYDCSAHMLWIGERTRGINDAHVHFLSGIKNPIGCKIGPDGKPGDIISLAGKLNPDNEPGRLNIIIRMGADKIEDRLPAILNYVKKEGLNILWSIDPMHGNTIKASSGFKTREFNNVMREVKSFFEIHRACGTIAGGVHLEMTGQDVTECVGGAFNVTEDSLGNRYETQCDPRLNADQALELAFLIADLVKKR
>NZ_CP008810.1|WP_025370330.1|690410_691178_+|hypothetical-protein
MAETLKEKFKGVLSANTSYFEGVSDHIISQAQNIARVNQSSKYGVKHYKVLARIDSRTSDICRSMNGRIIPASHIEAQSNNIQNAKDINEKKAAAIWRNEPFLGKILPSNFGLPPYHFRCRTELVPVWINEEEIDGVKMKNTSPLSKDEVVKHIDKTGVERYANKKTFNHSISSNKRKISSSDSVKALNSILKIAPHKDYQNRSVAISQNGYFMIFNGDYLYNIFKPSRNLEKYFKDSAVLNKVEIIKWKFSIFA
>NZ_CP008810.1|WP_002849067.1|691153_691471_+|hypothetical-protein
MEIFNICLAHGWAIESVKNGNFGENAKYDLFAQFDVFYGQIAWIYDICTPSDETIKECEKIAIFKQMCEFNVYISDDNDEGWTKKVNFTGTFIDALEYIKANFGK
>NZ_CP008810.1|WP_002849060.1|691511_691718_+|hypothetical-protein
MTIIEAFNKTKTLQNQNRNAVVKIVKKNYSGYDVQIEPVELTVIKNSLEMISQNANSFMANVNAKYGK
>NZ_CP008810.1|WP_038452375.1|693008_694454_+|acetyl-CoA-carboxylase-subunit-A
MIHKILIANRGEIAVRIVRACKDLHIKNVAIYTEPDRECLHVKVADEAYQIGKDPIKGYLDSKRIVEVAKACGADAIHPGYGFLSENYEFSKEVEDAGLIFIGPNSDIIRKMGNKNIARFLMKKNGIPVVPGTEKLNSETIEAIKNYAVRIGYPVILKASGGGGGRGIRVVWKEDELESSYESCKREAKAFFNNDEVFMEKYIEKPRHIEFQILGDNYGNLIHLCERDCSIQRRHQKVIEIAPCPTISEDLRKRMGVAAVAAAKAVGYTNAGTIEFLLDDYNNFYFMEMNTRIQVEHGVTEEITGVDLISRQIRIAAGEILDIEQNEVRPQGVSIEARITAENVWKNFAPSPGRITGYFPALGPGVRVDSHMYQDYVIPPFYDSLVAKLIVKGTSYDLAVSKLERALDEFKIEGVRTTLPFLLAISKRRHFRRGFFDTSYIEERLQDILENTQDHHQENKEEVIAAIAAAIKKVKEDRAKK
>NZ_CP008810.1|WP_002849076.1|694460_694697_+|hypothetical-protein
MNDFFDSLKNIKNELVKEQKSQEIKVPKKPKPNPNRDEFKDIFAEPNEIEMPDAKEHRLKDEFLEFIKHSDVKKLERD
>NZ_CP008810.1|WP_002849077.1|694683_695400_+|arginyltransferase
MREIDFCTLDTLCPYLEDRNSRTMYRYVSQCSFDYNSNLVKHGYRRFGSYFSKPICDGCDECKSIRIDAFNFKFTKSHRRIINKNSNTKIVVSKPYISQRHIDLYEKYHKFMHEKRGWEYYNLDFRRYYSVYVEGAGDFGYEIDYFVNDELVCVDLVDIVDDGISSIYCYWDIDFAHLSLGKFSLLNQITIALKNDLRWIYLGFYVKDCASLAYKGEYKPYETLKTYCDIDEKPIWEF
>NZ_CP008810.1|WP_011731910.1|695456_696281_+|adenylosuccinate-lyase
MQITQTLESITITTDDCDLFLNLSNKIRQSFANAIGNRDKVIIFYNENELVQRKYFLKLIGKIYANSVGKGIDFLLTHHKNIKLVYKKPNSLQILINVDVKFENSRVVLDLKNSEELFTKYLIRGLGDTRHEYFESKNILVISPKTTEDVELLDNILNFREHLKYIVNFNYDKKAYDEFKKRAKILTSKAYIRRFSMLANLLEEHFETLGCKATDDFETVRTNYLNLTKVYHPDKHAGKPNEVQKSYIDKFQKIGLAYEALKPYFKEQKSFISA
>NZ_CP008810.1|WP_011731911.1|696325_697099_+|pyridoxine-5'-phosphate-synthase
MKLGVNIDHVAVLREARAVNDPQIIHAMFEAVSGGADQITIHLREDRRHINEDDVKNIINLSPIPVNLECSINSEIIDIVCELKPHRATIVPEKREELTTEGGLSLDSLNLKNVISKLNDNDIKVSLFINPKKNDVIMSKELGATCVELHTGAYANTFLMLNSNLNHTKYKIDNLNLKRGELEILLNSELTRIKEAANISTNLGLEVAAGHGLNYQNVTAISSIKDIFELNIGQSIVAKSVFVGLKNAVKEMMELVK
>NZ_CP008810.1|WP_002849081.1|697095_698019_+|4-hydroxythreonine-4-phosphate-dehydrogenase
MSLPKIAISVGDINGVGIEIALKSHDEIKNICSPIYFINNELLNSAANILKFTVPNDFEIFECGSSFNIKPGRVSKKSGKFSFVSFENAILYTQNKRAQALVTMPINKESWKKAGVPYVGHTDALGKYFGKNAIMMLGCEELFVALYTDHLALKDVSAKIKAKNLALFLVDFYNSSKFENIGVLGFNPHASDNETIGGKEEKEIIKAIKSANNRLKKEVFTGPLVSDAAFTKSSLKRCNRLVSMYHDVGLAPLKALYFDKSINVSLNLPIVRTSVDHGTAFDIAYKGKAETKSYIEAIKFAIKLCDY
>NZ_CP008810.1|WP_046037358.1|698153_699635_+|inorganic-phosphate-transporter
MWGYNYIPSNHLLLFILASIFGLFMAFNIGGNDVANSFGTSVGAKTLTLKQALIIAAVFELSGAVFAGAEVTNTIRSGIVSLPRGDVNPMVFVIIMISALFSSGAWLFIATKKGLPVSTTHSIVGGIVGAGMMMGFIYYNGSKTFDMVQWGEIGRIALSWVISPVMGGVMAYLIFGYIKSKIIIPSSRIQSEIKSLKRARKTYKDQYIKELSNKSEAEQIKELRRIAIIDEDECEGENCDFRDKIKAMKEQEKNIDGMVFMRTHIPMVAGVAAMIIAGSMLFKGLKHMDFNLSIIQTIWIIFVIGIAAYLASFAIVNLMKKDNPQKGINRIFGWFQIFTASSFAFSHGANDIANAVGPFAAILDVLKNNTINETTPIPGIAMATFGIALVVGLWFLGKEVIATVGTKLAEILPTTGFSAELAASIVILIATKMGLPISSTHVLIGAVLGIGVYNRNANWGMLKPIGLAWIITLPISMIGSAIGFLVIKNIMGL

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Crispr_ID: NZ_CP008810_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP008810_2

1860940-1861074

TypeV

Consensus_repeat	Method
TATTTTCTATATTATTTCCTAGATCATCATAAATGATAAAAT	CRISPRCasFinder

1 spacers

c2c9_V-U4

The CRISPR arrays of NZ_CP008810_2

>merge|NZ_CP008810|2|1860940-1861074|CRISPRCasFinder
TATTTTCTATATTATTTCCTAGATCATCATAAATGATAAAATCATCATTAAAACTAAAAAAATTTCTTTTGTTATCAACTATTTCTTTTTCAATATTTTCTATATTATTTCCTAGATCATCATAAATGATAAAAT

>NZ_CP008810|2|2|1860940-1861074|CRISPRCasFinder
TATTTTCTATATTATTTCCTAGATCATCATAAATGATAAAAT	CATCATTAAAACTAAAAAAATTTCTTTTGTTATCAACTATTTCTTTTTCAA
TATTTTCTATATTATTTCCTAGATCATCATAAATGATAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP008810.1\|WP_035148343.1\|1856137_1856785_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|222854
NZ_CP008810.1\|WP_002850902.1\|1868411_1868846_-\|plasmid-mobilization-relaxosome-protein-MobC	unknown	unknown	gnl\|CDD\|368576
NZ_CP008810.1\|WP_002850914.1\|1864912_1865188_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008810.1\|WP_002850916.1\|1863664_1864864_-\|type-IV-secretion-system-protein	unknown	unknown	gnl\|CDD\|377390
NZ_CP008810.1\|WP_024305491.1\|1857255_1857534_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008810.1\|WP_024305357.1\|1855334_1855901_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008810.1\|WP_038452395.1\|1857580_1858579_-\|restriction-endonuclease-EcoRI-subunit-M	unknown	unknown	gnl\|CDD\|372662
NZ_CP008810.1\|WP_024305370.1\|1853252_1853495_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008810.1\|WP_002850907.1\|1866499_1868419_-\|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	unknown	unknown	gnl\|CDD\|226036
NZ_CP008810.1\|WP_002850910.1\|1866135_1866312_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008810.1\|WP_002850892.1\|1850104_1850665_+\|DUF86-domain-containing-protein	unknown	unknown	gnl\|CDD\|366864
NZ_CP008810.1\|WP_002850920.1\|1861136_1863077_-\|type-IA-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|223624
NZ_CP008810.1\|WP_002850911.1\|1865248_1866076_-\|DUF1738-domain-containing-protein	unknown	unknown	gnl\|CDD\|377992
NZ_CP008810.1\|WP_002850926.1\|1870413_1871052_-\|IS607-like-element-ISCfe1-family-transposase	unknown	unknown	gnl\|CDD\|239738
NZ_CP008810.1\|WP_158004709.1\|1855094_1855247_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008810.1\|WP_002850893.1\|1852924_1853239_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP008810.1\|WP_002850918.1\|1863058_1863646_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379235
NZ_CP008810.1\|WP_171819451.1\|1869134_1870427_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	c2c9_V-U4	-	gnl\|CDD\|223747
NZ_CP008810.1\|WP_002850891.1\|1849782_1850112_+\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393
NZ_CP008810.1\|WP_024305369.1\|1850684_1852313_-\|relaxase	unknown	unknown	gnl\|CDD\|226362

Protein	Function_ID	Function_description	E-value
NZ_CP008810.1\|WP_035148343.1\|1856137_1856785_-\|AAA-family-ATPase	gnl\|CDD\|222854	PHA02518, PHA02518, ParA-like protein; Provisional.	1.7133e-39
NZ_CP008810.1\|WP_002850902.1\|1868411_1868846_-\|plasmid-mobilization-relaxosome-protein-MobC	gnl\|CDD\|368576	pfam05713, MobC, Bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region. The absence of MobC has several different effects on oriT DNA. Site- and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency of mobilisation. The localized DNA strand separation required for this nicking is less affected, but becomes more sensitive to the level of active DNA gyrase in the cell. In addition, strand separation is not efficiently extended through the region containing the nick site. These effects suggest a model in which MobC acts as a molecular wedge for the relaxosome-induced melting of oriT DNA. The effect of MobC on strand separation may be partially complemented by the helical distortion induced by supercoiling. However, MobC extends the melted region through the nick site, thus providing the single-stranded substrate required for cleavage by MobA.	0.00151096
NZ_CP008810.1\|WP_002850891.1\|1849782_1850112_+\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	3.52331e-10
NZ_CP008810.1\|WP_002850907.1\|1866499_1868419_-\|type-IV-secretory-system-conjugative-DNA-transfer-family-protein	gnl\|CDD\|226036	COG3505, VirD4, Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion].	1.18638e-62
NZ_CP008810.1\|WP_002850926.1\|1870413_1871052_-\|IS607-like-element-ISCfe1-family-transposase	gnl\|CDD\|239738	cd03769, SR_IS607_transposase_like, Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.	2.71254e-63
NZ_CP008810.1\|WP_002850892.1\|1850104_1850665_+\|DUF86-domain-containing-protein	gnl\|CDD\|366864	pfam01934, DUF86, Protein of unknown function DUF86. The function of members of this family is unknown.	0.000223926
NZ_CP008810.1\|WP_002850920.1\|1861136_1863077_-\|type-IA-DNA-topoisomerase	gnl\|CDD\|223624	COG0550, TopA, Topoisomerase IA [DNA replication, recombination, and repair].	1.1352e-137
NZ_CP008810.1\|WP_002850911.1\|1865248_1866076_-\|DUF1738-domain-containing-protein	gnl\|CDD\|377992	pfam08401, DUF1738, Domain of unknown function (DUF1738). This region is found in a number of bacterial hypothetical proteins. Some members are annotated as being similar to replication primases, and in fact this region is often found together with the Toprim domain (pfam01751).	0.00766572
NZ_CP008810.1\|WP_038452395.1\|1857580_1858579_-\|restriction-endonuclease-EcoRI-subunit-M	gnl\|CDD\|372662	pfam13651, EcoRI_methylase, Adenine-specific methyltransferase EcoRI. This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease.	2.80198e-91
NZ_CP008810.1\|WP_002850918.1\|1863058_1863646_-\|AAA-family-ATPase	gnl\|CDD\|379235	pfam13521, AAA_28, AAA domain.	1.73817e-08
NZ_CP008810.1\|WP_171819451.1\|1869134_1870427_-\|IS200/IS605-family-element-transposase-accessory-protein-TnpB	gnl\|CDD\|223747	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.67719e-44
NZ_CP008810.1\|WP_002850916.1\|1863664_1864864_-\|type-IV-secretion-system-protein	gnl\|CDD\|377390	pfam04610, TrbL, TrbL/VirB6 plasmid conjugal transfer protein.	0.000267097
NZ_CP008810.1\|WP_024305369.1\|1850684_1852313_-\|relaxase	gnl\|CDD\|226362	COG3843, VirD2, Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion].	6.73554e-05

>NZ_CP008810.1|WP_038452395.1|1857580_1858579_-|restriction-endonuclease-EcoRI-subunit-M
MNHKNQLNQETNWMSNKEKKPNIYFMKAKYEIDDEFYTSYHEIKKELDDYKSHFKGKIVVCPCNDSRKSNFYRYFSLNFKALELKKLITTTFDISDPNSKGTKIEITNDSASETELQGRGDFRSDEVKEIIAQGDIIVTNPPFSLFRDLIDIVESYNKKFLIVGGTYSITYKKIFELYEKGKIWLRNHQVCIFTRPNGTKKRFSNISWFTNLKSIKHLEPIKLTKRYKNNEHKYPEYDNYKVIEVTSYKDIPIDYYGIIGVPLTFFLRHNPAQFNILGCDFQIKEKYPELVKWDYKENNTKSAVLNGQEMFTRIIVQRKSGLMPRIRLQNQL
>NZ_CP008810.1|WP_024305491.1|1857255_1857534_-|hypothetical-protein
MKFEELEFSGLPDNFLCQKVCEIYKITNKELSDKLGIEIEVLNSLQDNDVRLPKSAKVALELMHIIDIWYNTDLIFKERVVKDETKQEIKTI
>NZ_CP008810.1|WP_035148343.1|1856137_1856785_-|AAA-family-ATPase
MIVSICNEKGGSGKSTLATNIAINQSLSKNELPLLIDTDPQKSIATFLNIRNEENNPKVFDFTYKYGENLKEFLQNYNSNKDVIIDTGGRDSREMRIAIALSDMVIIPTIPSQFDVSVLDKMVNIIKMAKEQNEKLVAYIVINRASTNPFLYKKIESLRNFIEELEQDYIKLSQTIIYERERYKVATQLGLGVVEMKDGNKAEQEIRDLCNEICT
>NZ_CP008810.1|WP_024305357.1|1855334_1855901_-|hypothetical-protein
MNFKKTTNSIENLDAFIDGADTQKDTSIDKKVSVVTKISKELSNKIKLKYPKMPLTKYIEQALMVKIPHINEDILLTICQQAEWFNTSIADFVRYKMGLMEAPEPNELNKNEEKLENKILYVSNDNKKIIKRNAENIGLSLYRYSEIKIKVTYELKDIFTFEELMQFKAEAINYDLELDEYIAMRIRG
>NZ_CP008810.1|WP_158004709.1|1855094_1855247_+|hypothetical-protein
MIEESNKTIEQIARESLHSLEMTFENFAIFGVCSLMIIGIVTALILSSTR
>NZ_CP008810.1|WP_024305370.1|1853252_1853495_+|hypothetical-protein
MVVTDCYMDLTKKTKIMGLTTTSLLIIFVVGFVAWFILILYSLAVVAVLYCFFFVLEFFDEDIYEIIGSKMKISQNKFYA
>NZ_CP008810.1|WP_002850893.1|1852924_1853239_+|hypothetical-protein
MKKILKNFKKLYWLLACSPVFLFGAGGQNVLKTLEQNVNQQITEAGGSFASVLNTIVLVIGILWIIVLMLGALFNVEAIKNHIKFVIIASIVLGVTYGLTAAAM
>NZ_CP008810.1|WP_024305369.1|1850684_1852313_-|relaxase
MSSIDWDKYFDDLKAIRAGRTKFIKSEHKNISFGSGKGFFGAGINFSKNNFTKQSVIKMISNLPKTSIKKCIDYALKNSLDGYAINEKGERVGSDEVMSAWSKDFGTNKNSKDAWHLMFSINEPCNDKSSLYALQDAVKDILGRNFQGHKYAMVLHTHQNNPHMHVVLNKKNNFTGKKIHFDSRLEIREFFDDARDAFAYALSARGLKYENKNFLDKDLKSEFNKIKSNIKLEVDSYTAKDKINDYYDKMQDKNKAKYDATTKHIEIMNDELEKLKKANKELLNLFLQYSKKRNKKAFKLAKELKESNKIIKQESLKILSEIKKVNKLSFDATRLNEMKLANYKDRSNALTLLENFSYNYNKLYPKNKGASKADFENYKKVKRTIAILRDRKDDDAKKYFDDSLIVTRMLGRNESLFKLGKKLEILDKNLYILEHSELGIDEAKEYKKRLNDNKEFISDVCDKRFDYVATKLLKSENIKGDEFLFKEYFCGVALLNKEPNEKLLKIKKEVDLMAKFNKNHSIKREKVKNRASLEVKQDLGRE
>NZ_CP008810.1|WP_002850892.1|1850104_1850665_+|DUF86-domain-containing-protein
MSNKIIYRLELAIEKIDQVFEVCKPKGITAALKDELLTKPAIMKHIDVVYQQFDKLEKAQEYHVLDKFSKDDLKGIRNIRNWSSHDYDNIQNEIIENVIRTNLPKLKQNLQKVLEETKKELCKDLEKNIDYFIKKQDILMPEAKTDLAKTIEKEYKRLQESGVELDKSYSDKIKNIIKENSKENQR
>NZ_CP008810.1|WP_002850891.1|1849782_1850112_+|nucleotidyltransferase-domain-containing-protein
MSSSVLAQKDILSYLSELKPSLQKDGIKEIGLFGSYAKGYADENSDIDIVVLADKKSFLDRLNAFKALEYLSDLKEKITNKFHKSVDICDFYSEEKMKNNKIVKGAIYV
>NZ_CP008810.1|WP_002850920.1|1861136_1863077_-|type-IA-DNA-topoisomerase
MQNTIIIIESPNKCDKIEHITGAKVYATKGHFKELTNQIVADYQSYEPIFDFKGESKSRINAMFNDCKGKDVIIATDPDREGYGIGYMVYDTIKNIAKSVKRAEFHEITESGIKKGLESAVPFASSNLKEFDSFKARAVGDKLVGFIMSPTYINKLNDKNISVGRVQTPALALIVKRELEIKAFNENKANAKIDYKIKAKLRTRDGIEFNALNDNIFVSKDEANAKISDLNGFNAKVYQIDTKETQIKPKLPFRTSQLQEIANKKLLFSPDKTMSIAQKLFEKGLITYHRTDSNSLSNEFIDEVGAKFGDEEWYEKREYKAGAQSQAEAHEAIRITHVHNFISIDEMALTDDDKRLYELIYLNSIQSQAKNAINENTIYDIDIKTLSFKTKTSKCIYKGFKGALKEEIEDDEDKDKEILEISLNLKQGDEVELMGFELQEVKKQPPQHYKESNFISLLEKEGIGRPSTYATFLPTLLKREYVTIETKGKNNNIVATNKGIKFIENIKQDDDWITQSEFTKQMESVLDEISSGKVSYLDFIKPLHEKMGFKELNNSQTNPPSEKQLEWAKNIAQNLKISLPNGIENSWKICSDFIEKNKDKVVTPPTDKQIELAKKLSKDKGMALPKDYDTNLKICKEFIDKAIKKK
>NZ_CP008810.1|WP_002850918.1|1863058_1863646_-|AAA-family-ATPase
MNKLVINIYGSPGAGKSTLAKNLKKYMREKRIDVGLISEFATELIENNQKEKLKDQPYVTKGQMLNITRVLKKHDIAISDSPIELGKFYCDPRDEQRTNELIKKCKNMYKSINFFLKLDEQAKQDYTMERRVHTYAQSKKLQEEMLSSLILNDKTSIIIYRSTPIKEIFKMIEKSKQWNKHQNQNKGLELCKTQS
>NZ_CP008810.1|WP_002850916.1|1863664_1864864_-|type-IV-secretion-system-protein
MAQTQVAKDLLTDSNWINKTQNIIQENVMSLFEKFYQGAHDLVYSTATTTIVILIVSLWLLNRLKNGYPTRNEIFVAVKYIIQLCFIFAILSSFDAYQGVLYALTIPENVIITILSSIFEGRDFGAIVTESANRVDNIRALMWNYGTTEYLKTQAWSFLGISFNGVMDYLGAGIITALSMIPFWIFYIVFFLLLVGITIVIFFSKFMAFLILSTLPLVIPFLIIPRFLPYLWSWYKLYLSYAIIAPLAFIALNLAINPILELENYQNYISELFVKQFEYLITGSITCISALFLLKKIPSWINAVLGTQMESGSGGVVGGVVAGAVASKTLLGGLARKATGGSFVGGALSSLGAASGANVAGQIASASIGAGANVAKDIGRGIGKTYEAYKKFKGGYVAP
>NZ_CP008810.1|WP_002850914.1|1864912_1865188_-|hypothetical-protein
MLNEFLNFLGFNKAVCKKQLHTDNTDIKENVEMQEYIVEMQSPDFKEETTTETVIKDGKKIEIQKIKTTEPLNNGKTLITTKIYKKDITRM
>NZ_CP008810.1|WP_002850911.1|1865248_1866076_-|DUF1738-domain-containing-protein
MEQVRKSWEQMDNAEKKESFDKYMKFKLFEAHKTGKADWQKDMSKEEVDNTMPYNAKTGNTYSRETNMLLRAEMAIKGYDKAQFVTMEQGNAMGGVLKLKHDEQTGEVVKTKNGKDARVDGVKMLYIADHELRPKLDKDGKEVTAVVKDKDGNVKYDQETGQPMTYVVKEKIPIKPRLETKTLYHVSQFDGLDESKIKDRDLTAVTHYREQSKNQDFEVKISYGKTLGISGNLEKQLDNLTLAQIKGVDYYNPAVKVEMTKQKAQTKEQNKGMER
>NZ_CP008810.1|WP_002850910.1|1866135_1866312_-|hypothetical-protein
MTYQEKLEQEKAYKEYEKHLAEQFAQSEDGEFEISDSECKGLEYLKQAHQEIGSTDKN
>NZ_CP008810.1|WP_002850907.1|1866499_1868419_-|type-IV-secretory-system-conjugative-DNA-transfer-family-protein
MDDTQKFSTKKWIIIFISSLIMGVLAYLAMVKVIFNPDLVNVPAVAIKILNNIGSPMLKLKAYVALFALVAPFLVVVAWWLMPYFSDNENYGSARFATPDDFKKMSINYKNGLVLGCLNIDSENPKFLRATRPLATLVVAPPGSGKTAGMIIPNLLSIPNSSVTLDIKGELYQKTAGYRQKYFKNEIQLFSPFSWDNTLFFNPFDYSIVKDMEYIRIKKLADQIANTIFVAEKEKENDHWVLSAKTLFVFFAEYFMQKNKHTTLGELAQAPKADYFDYLDEKFGEEAMKEIDEDNPEAPRERDYDVDTFKIWLKQTANDTSIDESTRNQARAYAKAAENEFASIKSTYDTFMKVFSHPQVASATSKMSFAFEDLREKRISMYVVIQTEDMEILAPLIRIFIETLFKKLMSGKENSDPDKFIYCFLDEFVRFGKMPFLLEAPALCRSYGLLPVFVTQAYEQIKKYYGEDDMNIVKNNSGYHVIFGMNSEKDAKDTSELIGDYTNIKISKSQGNMDLFKSNISKSKEAKRLVTAQDLKNQDSNDIYILVSKFFKMPIKAKVPYWFKIVQFKGANEIEVKAIAQKEQTNTHKPQDTNILQNSPATAQQNSQKTNESKVEVADMDKQQRDELLKALKIKVDRE
>NZ_CP008810.1|WP_002850902.1|1868411_1868846_-|plasmid-mobilization-relaxosome-protein-MobC
MKKTRHHIYLTEADDRILRKLSDKQNQSRSAIVRKLLQTQKYKDNLKEIETNNRIIGGYLKEFSHIGTNINQIAYHLNANITDHEEAKTDFEKNIVKLMQIIKELNEKIDTLKIKINVPHIKTPSNIKERDRMEEYEIKRKENG
>NZ_CP008810.1|WP_171819451.1|1869134_1870427_-|IS200/IS605-family-element-transposase-accessory-protein-TnpB
MSKTNQSNLISISHKIELKPNNKAITHFKKAFGCSRLAYNWGLAKWQEYYKQGVKKSYLDLKKEFNAIKKEQFPFVYDVSKYATQQPFLNLNLAFNKFFRDLKQGKLSYPKFKKKKENFGSYYIGGDQIIIKNEKYLKIPNFGLVKIREKLRFNGKINSVTISQKANKFYASFSMQISHDEYNKTHKIKNLNNQSIGIDLGIKEFVCLSNGLMIKAPKPLNKLTRLLVKRQRRLSKKQHAKTKQEAINGVKKSNNYLKESKKLAKLHSKIANIRSDFLHKLSSIIIKNFDYIGLESLNVKGMIKNHKLAKSLVDVSFYEFNRQLEYKANYMQKEIHRVDKFYPSSKTCCVCGNIKQDLTLKDRIYKCKSCGNIIDRDLNASINLHKFVNETVGIVNSEFTPMDLTALLDDLAINQIVTSKVEVGIQQKFY
>NZ_CP008810.1|WP_002850926.1|1870413_1871052_-|IS607-like-element-ISCfe1-family-transposase
MSKLLSIGQASKALGVTIQTLRNWDKKGLLKPDELTRGGERRYKLETLKNINKNIVFKNDNLKTIAYARVSSNDQKDDLIRQVQVLELYCSKQGFNYEIIQDLGSGMNYYKKGLTRLLNLILDGEVKRLVLTHKDRLLRFGAELVFAICEAKEVEVIIINKGEENVKFEEELAKDVLEIITVFSARLYGSRSKKNKKLIDEMKEVVNNNVKN

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP008810_1	1.10\|689347\|37\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689347-689383	37	NZ_CP008810.1	732716-732752	1	0.973
NZ_CP008810_1	1.10\|689347\|37\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689347-689383	37	NZ_CP008810.1	1295560-1295596	1	0.973
NZ_CP008810_1	1.11\|689414\|36\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689414-689449	36	NZ_CP008810.1	729705-729740	2	0.944
NZ_CP008810_1	1.11\|689414\|36\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689414-689449	36	NZ_CP008810.1	1298573-1298608	2	0.944

1. spacer 1.10|689347|37|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to position: 732716-732752, mismatch: 1, identity: 0.973

tccagagctaataagggatttagagcagctaaaaact	CRISPR spacer
tccagagctaataagggatttagagcagctaaagact	Protospacer
*********************************.***

2. spacer 1.10|689347|37|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to position: 1295560-1295596, mismatch: 1, identity: 0.973

tccagagctaataagggatttagagcagctaaaaact	CRISPR spacer
tccagagctaataagggatttagagcagctaaagact	Protospacer
*********************************.***

3. spacer 1.11|689414|36|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to position: 729705-729740, mismatch: 2, identity: 0.944

cgcaaaaagagttgaaatatatagataataggttaa	CRISPR spacer
cgcaaaaagaattaaaatatatagataataggttaa	Protospacer
**********.**.**********************

4. spacer 1.11|689414|36|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to position: 1298573-1298608, mismatch: 2, identity: 0.944

cgcaaaaagagttgaaatatatagataataggttaa	CRISPR spacer
cgcaaaaagaattaaaatatatagataataggttaa	Protospacer
**********.**.**********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP008810_1	1.10\|689347\|37\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689347-689383	37	NZ_CP007000	Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence	37229-37265	2	0.946
NZ_CP008810_1	1.10\|689347\|37\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689347-689383	37	NZ_CP014569	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence	34209-34245	2	0.946
NZ_CP008810_1	1.11\|689414\|36\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689414-689449	36	NZ_CP014569	Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence	8545-8580	2	0.944
NZ_CP008810_1	1.11\|689414\|36\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689414-689449	36	NZ_CP007000	Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence	79920-79955	2	0.944
NZ_CP008810_1	1.25\|690335\|36\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	690335-690370	36	NZ_CP034117	Staphylococcus epidermidis strain CDC121 plasmid pSTA482, complete sequence	6189-6224	7	0.806
NZ_CP008810_1	1.11\|689414\|36\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689414-689449	36	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	42976-43011	9	0.75
NZ_CP008810_1	1.17\|689809\|35\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689809-689843	35	MK573636	Escherichia phage vB_EcoM_PHB13, partial genome	114101-114135	10	0.714
NZ_CP008810_1	1.17\|689809\|35\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689809-689843	35	MT764208	Escherichia phage JEP8, complete genome	35159-35193	10	0.714
NZ_CP008810_1	1.17\|689809\|35\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689809-689843	35	MT478991	Escherichia phage vB_EcoM_011D4, complete genome	71742-71776	10	0.714
NZ_CP008810_1	1.17\|689809\|35\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689809-689843	35	NC_009821	Enterobacteria phage Phi1, complete genome	121045-121079	10	0.714
NZ_CP008810_1	1.17\|689809\|35\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689809-689843	35	NC_025425	Enterobacteria phage GEC-3S complete genome	120585-120619	10	0.714
NZ_CP008810_1	1.17\|689809\|35\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689809-689843	35	NC_041936	Escherichia phage ECD7, complete genome	123453-123487	10	0.714
NZ_CP008810_1	1.17\|689809\|35\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689809-689843	35	MK327935	Escherichia phage vB_EcoM_G2494, complete genome	123386-123420	10	0.714
NZ_CP008810_1	1.17\|689809\|35\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689809-689843	35	MK962753	Shigella phage JK32, complete genome	133835-133869	10	0.714
NZ_CP008810_1	1.17\|689809\|35\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	689809-689843	35	NZ_MK275621	Clostridium perfringens strain JXJA17 plasmid p3, complete sequence	46854-46888	11	0.686
NZ_CP008810_1	1.25\|690335\|36\|NZ_CP008810\|PILER-CR,CRISPRCasFinder,CRT	690335-690370	36	KJ018209	Shewanella sp. phage 1/4, complete genome	128607-128642	11	0.694

1. spacer 1.10|689347|37|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007000 (Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence) position: , mismatch: 2, identity: 0.946

tccagagctaataagggatttagagcagctaaaaact	CRISPR spacer
tccggagctaataagggatttagagcagctaaagact	Protospacer
***.*****************************.***

2. spacer 1.10|689347|37|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014569 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence) position: , mismatch: 2, identity: 0.946

tccagagctaataagggatttagagcagctaaaaact	CRISPR spacer
tccggagctaataagggatttagagcagctaaagact	Protospacer
***.*****************************.***

3. spacer 1.11|689414|36|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014569 (Campylobacter fetus subsp. venerealis strain 01/165 plasmid mp1, complete sequence) position: , mismatch: 2, identity: 0.944

cgcaaaaagagttgaaatatatagataataggttaa	CRISPR spacer
cgcaaaaagaattaaaatatatagataataggttaa	Protospacer
**********.**.**********************

4. spacer 1.11|689414|36|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP007000 (Campylobacter fetus subsp. venerealis cfvi03/293 plasmid pCfviMP1, complete sequence) position: , mismatch: 2, identity: 0.944

cgcaaaaagagttgaaatatatagataataggttaa	CRISPR spacer
cgcaaaaagaattaaaatatatagataataggttaa	Protospacer
**********.**.**********************

5. spacer 1.25|690335|36|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034117 (Staphylococcus epidermidis strain CDC121 plasmid pSTA482, complete sequence) position: , mismatch: 7, identity: 0.806

catcctccttttaatttattacatttaaacaattta	CRISPR spacer
aatcctcctttgaattcattacatttaaaacatatc	Protospacer
 ********** ****.************  ** *

6. spacer 1.11|689414|36|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 9, identity: 0.75

cgcaaaaagagttgaaatatatagataataggttaa	CRISPR spacer
tagcaaaatatttgaaatatatagataatagcggaa	Protospacer
..  **** * ********************   **

7. spacer 1.17|689809|35|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to MK573636 (Escherichia phage vB_EcoM_PHB13, partial genome) position: , mismatch: 10, identity: 0.714

ccttctgcgatatatttgatgaaaaaacagaaagg	CRISPR spacer
cgatctgcgatatattcgatgaaaagaccgctcat	Protospacer
*  *************.********.** *   .

8. spacer 1.17|689809|35|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to MT764208 (Escherichia phage JEP8, complete genome) position: , mismatch: 10, identity: 0.714

ccttctgcgatatatttgatgaaaaaacagaaagg	CRISPR spacer
cgatctgcgatatattcgatgaaaagaccgctcat	Protospacer
*  *************.********.** *   .

9. spacer 1.17|689809|35|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to MT478991 (Escherichia phage vB_EcoM_011D4, complete genome) position: , mismatch: 10, identity: 0.714

ccttctgcgatatatttgatgaaaaaacagaaagg	CRISPR spacer
cgatctgcgatatattcgatgaaaagaccgctcat	Protospacer
*  *************.********.** *   .

10. spacer 1.17|689809|35|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to NC_009821 (Enterobacteria phage Phi1, complete genome) position: , mismatch: 10, identity: 0.714

ccttctgcgatatatttgatgaaaaaacagaaagg	CRISPR spacer
cgatctgcgatatattcgatgaaaagaccgctcat	Protospacer
*  *************.********.** *   .

11. spacer 1.17|689809|35|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to NC_025425 (Enterobacteria phage GEC-3S complete genome) position: , mismatch: 10, identity: 0.714

ccttctgcgatatatttgatgaaaaaacagaaagg	CRISPR spacer
cgatctgcgatatattcgatgaaaagaccgctcat	Protospacer
*  *************.********.** *   .

12. spacer 1.17|689809|35|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to NC_041936 (Escherichia phage ECD7, complete genome) position: , mismatch: 10, identity: 0.714

ccttctgcgatatatttgatgaaaaaacagaaagg	CRISPR spacer
cgatctgcgatatattcgatgaaaagaccgctcat	Protospacer
*  *************.********.** *   .

13. spacer 1.17|689809|35|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to MK327935 (Escherichia phage vB_EcoM_G2494, complete genome) position: , mismatch: 10, identity: 0.714

ccttctgcgatatatttgatgaaaaaacagaaagg	CRISPR spacer
cgatctgcgatatattcgatgaaaagaccgctcat	Protospacer
*  *************.********.** *   .

14. spacer 1.17|689809|35|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to MK962753 (Shigella phage JK32, complete genome) position: , mismatch: 10, identity: 0.714

ccttctgcgatatatttgatgaaaaaacagaaagg	CRISPR spacer
cgatctgcgatatattcgatgaaaagaccgctcat	Protospacer
*  *************.********.** *   .

15. spacer 1.17|689809|35|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to NZ_MK275621 (Clostridium perfringens strain JXJA17 plasmid p3, complete sequence) position: , mismatch: 11, identity: 0.686

ccttctgcgatatatttgatgaaaaaacagaaagg	CRISPR spacer
aaaataaagatatatttgataaaaaaatagaaatg	Protospacer
    . . ************.******.***** *

16. spacer 1.25|690335|36|NZ_CP008810|PILER-CR,CRISPRCasFinder,CRT matches to KJ018209 (Shewanella sp. phage 1/4, complete genome) position: , mismatch: 11, identity: 0.694

catcctccttttaatttattacatttaaacaattta	CRISPR spacer
ggctattattttaattcattacatttaaacacttct	Protospacer
 ... *. ********.************** **.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

456490 : 509389

Helicobacter_phage(40.0%)

integrase,portal,transposase

attL 456014:456031|attR 479582:479599

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
456014:456031	attL	NA	NA	NA	NA
WP_171819451.1\|456490_457783_-\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1S5RFS3	Helicobacter_phage	6.5e-119	55.9
WP_002850926.1\|457769_458408_-\|transposase	IS607-like element ISCfe1 family transposase	A0A1S5RGS9	Helicobacter_phage	2.9e-96	85.6
WP_038452362.1\|458471_459215_-	tape measure protein	V9QL83	Rhizobium_phage	4.7e-21	51.3
WP_158004714.1\|459392_459566_-	hypothetical protein	NA	NA	NA	NA
WP_002848799.1\|459691_460189_-	hypothetical protein	NA	NA	NA	NA
WP_002848800.1\|460199_461126_-	hypothetical protein	NA	NA	NA	NA
WP_035148494.1\|461127_461334_-	hypothetical protein	NA	NA	NA	NA
WP_035148490.1\|461330_461648_-	hypothetical protein	NA	NA	NA	NA
WP_035148488.1\|461657_461951_-	hypothetical protein	NA	NA	NA	NA
WP_002848806.1\|461952_462288_-	hypothetical protein	NA	NA	NA	NA
WP_038452363.1\|462299_463211_-	hypothetical protein	NA	NA	NA	NA
WP_167497333.1\|463210_463966_-	hypothetical protein	NA	NA	NA	NA
WP_038452364.1\|464285_465362_+\|portal	phage portal protein	NA	NA	NA	NA
WP_038452365.1\|465452_467024_+	hypothetical protein	A0A1B0T6F0	Thiobacimonas_phage	2.4e-38	31.9
WP_035148032.1\|467188_467626_+	HK97 gp10 family phage protein	A0A0F6WEN4	Mycobacterium_phage	4.4e-11	35.6
WP_002848719.1\|467683_468019_-	hypothetical protein	NA	NA	NA	NA
WP_035148030.1\|468030_468366_-	hypothetical protein	NA	NA	NA	NA
WP_038452366.1\|468362_469598_-	hypothetical protein	NA	NA	NA	NA
WP_002848725.1\|469587_469794_-	hypothetical protein	NA	NA	NA	NA
WP_051936711.1\|469797_470226_-	hypothetical protein	NA	NA	NA	NA
WP_002848729.1\|470182_470656_-	hypothetical protein	NA	NA	NA	NA
WP_002848731.1\|470715_470922_-	hypothetical protein	NA	NA	NA	NA
WP_035148325.1\|470979_471393_-	hypothetical protein	NA	NA	NA	NA
WP_035148323.1\|471486_471759_-	hypothetical protein	NA	NA	NA	NA
WP_141070520.1\|471772_471991_-	hypothetical protein	NA	NA	NA	NA
WP_002848749.1\|471974_472220_-	hypothetical protein	NA	NA	NA	NA
WP_158004716.1\|472212_472362_-	hypothetical protein	NA	NA	NA	NA
WP_050981936.1\|472358_472679_-	hypothetical protein	NA	NA	NA	NA
WP_050981937.1\|472698_473304_-	AAA family ATPase	A0A2D1GNS0	Pseudomonas_phage	2.6e-17	33.7
WP_038452367.1\|473720_476471_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_002848751.1\|476472_476634_-	hypothetical protein	NA	NA	NA	NA
WP_025370430.1\|476879_477662_+	LexA family transcriptional regulator	F1C5C2	Cronobacter_phage	4.1e-07	31.0
WP_035147980.1\|477760_479209_+	hypothetical protein	NA	NA	NA	NA
WP_002848683.1\|484271_485573_-	TolC family protein	NA	NA	NA	NA
479582:479599	attR	NA	NA	NA	NA
WP_002848685.1\|485562_486846_-	HlyD family type I secretion periplasmic adaptor subunit	NA	NA	NA	NA
WP_002848686.1\|486845_488597_-	type I secretion system permease/ATPase	A0A2H4UU96	Bodo_saltans_virus	1.8e-18	24.1
WP_002848689.1\|488583_489726_-	SapC family protein	NA	NA	NA	NA
WP_046037123.1\|490214_493043_+	hypothetical protein	NA	NA	NA	NA
WP_052040944.1\|493786_497158_-	hypothetical protein	NA	NA	NA	NA
WP_010398810.1\|497390_497663_-	type II toxin-antitoxin system YafQ family toxin	NA	NA	NA	NA
WP_010398813.1\|497655_497904_-	hypothetical protein	NA	NA	NA	NA
WP_038452370.1\|498149_500915_-	hypothetical protein	NA	NA	NA	NA
WP_002848691.1\|501219_502608_-	ATP-binding protein	NA	NA	NA	NA
WP_035170624.1\|506880_507762_+	hypothetical protein	NA	NA	NA	NA
WP_035171449.1\|507855_508311_+\|transposase	IS200/IS605 family transposase	G9CU69	Helicobacter_phage	3.3e-65	80.3
WP_038452371.1\|508288_509389_+\|transposase	transposase	G9CU70	Helicobacter_phage	1.7e-99	52.9

DBSCAN-SWA_2

842636 : 857922

Diachasmimorpha_longicaudata_entomopoxvirus(22.22%)

tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_024305216.1\|842636_843884_-	insulinase family protein	L7RBE7	Acanthamoeba_polyphaga_moumouvirus	9.3e-38	29.9
WP_002849228.1\|843884_844943_-	quinone-dependent dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_011731955.1\|844994_846713_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.7e-59	30.1
WP_024305217.1\|846709_848089_-\|tRNA	cysteine--tRNA ligase	A0A1V0SAQ2	Catovirus	7.6e-49	32.1
WP_011731957.1\|848072_849473_-	murein biosynthesis integral membrane protein MurJ	NA	NA	NA	NA
WP_038452386.1\|849830_850136_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	1.9e-08	36.3
WP_010404250.1\|850227_850683_+\|transposase	IS200/IS605 family transposase	G9CU69	Helicobacter_phage	1.7e-66	82.3
WP_010404252.1\|850660_851761_+\|transposase	transposase	G9CU70	Helicobacter_phage	1.3e-99	52.1
WP_052040946.1\|851834_853214_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	8.4e-40	34.7
WP_002849230.1\|853420_853573_+	EexN family lipoprotein	NA	NA	NA	NA
WP_024305219.1\|854272_854839_+	molybdopterin-guanine dinucleotide biosynthesis protein MobB	NA	NA	NA	NA
WP_011731960.1\|854822_855683_+	class 1 fructose-bisphosphatase	A0A1V0SKX4	Klosneuvirus	6.2e-25	33.5
WP_167497348.1\|855819_856005_+	hypothetical protein	NA	NA	NA	NA
WP_002849239.1\|856023_857922_+\|tRNA	methionine--tRNA ligase	A0A1V0SEZ7	Hokovirus	2.8e-86	33.8

DBSCAN-SWA_3

1491761 : 1503011

Cronobacter_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002850239.1\|1491761_1492763_+	glycosyltransferase family 2 protein	F1C5B0	Cronobacter_phage	4.8e-61	41.5
WP_011732184.1\|1492767_1494285_+	glucosyltransferase domain-containing protein	F1C5A9	Cronobacter_phage	2.3e-06	24.9
WP_029662383.1\|1494285_1494666_+	GtrA family protein	NA	NA	NA	NA
WP_002850245.1\|1494666_1495659_-	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	4.6e-56	41.1
WP_002850250.1\|1495721_1499579_-	restriction endonuclease subunit S	E3T4D5	Cafeteria_roenbergensis_virus	1.3e-10	29.8
WP_002850252.1\|1499657_1499900_-	hypothetical protein	NA	NA	NA	NA
WP_002850254.1\|1499910_1500675_-	DNA ligase	A0A1X9VNU1	Mimivirus	1.7e-34	34.0
WP_002850256.1\|1500725_1501784_-	NAD-dependent epimerase	A0A2K9L4U8	Tupanvirus	7.2e-31	29.1
WP_011732189.1\|1501793_1503011_-	nucleotide sugar dehydrogenase	M1HWZ1	Paramecium_bursaria_Chlorella_virus	1.3e-28	28.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP008811

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

14103 : 27434

Megavirus(16.67%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_040126343.1\|14103_16035_+	type IA DNA topoisomerase	L7Y5M3	Megavirus	1.1e-50	28.3
WP_035148389.1\|16048_16459_+	hypothetical protein	NA	NA	NA	NA
WP_040126344.1\|16508_16949_+	hypothetical protein	NA	NA	NA	NA
WP_040126345.1\|16976_17390_+	single-stranded DNA-binding protein	D5LH30	Escherichia_phage	3.7e-15	46.1
WP_052040953.1\|17390_17888_+	lytic transglycosylase domain-containing protein	A0A0K2QQJ4	Ralstonia_phage	1.3e-06	35.6
WP_040126346.1\|17884_18907_+	toprim domain-containing protein	NA	NA	NA	NA
WP_052040954.1\|19015_23902_+	Eco57I restriction-modification methylase domain-containing protein	I3PUW5	Vibrio_phage	4.8e-223	36.1
WP_052040955.1\|23888_24071_+	hypothetical protein	A0A0R6PEW9	Moraxella_phage	2.3e-06	51.0
WP_052040956.1\|24072_24963_+	hypothetical protein	NA	NA	NA	NA
WP_040126347.1\|25022_25280_-	hypothetical protein	NA	NA	NA	NA
WP_040126348.1\|25269_25833_-	hypothetical protein	NA	NA	NA	NA
WP_052040957.1\|26244_26742_+	Abi family protein	NA	NA	NA	NA
WP_040126349.1\|26795_27434_+\|transposase	IS607 family transposase	A0A1S5RGS9	Helicobacter_phage	5.0e-96	85.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP008812

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 11461

Helicobacter_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002851014.1\|0_741_+	hypothetical protein	NA	NA	NA	NA
WP_080582792.1\|1066_1930_+	P-type conjugative transfer protein TrbJ	NA	NA	NA	NA
WP_002851017.1\|1976_2240_+	EexN family lipoprotein	NA	NA	NA	NA
WP_134853945.1\|2157_3426_+	P-type conjugative transfer protein TrbL	NA	NA	NA	NA
WP_002851021.1\|3589_4273_+	conjugal transfer protein TrbF	NA	NA	NA	NA
WP_040126357.1\|4291_5206_+	P-type conjugative transfer protein TrbG	NA	NA	NA	NA
WP_002851027.1\|5206_5644_+	hypothetical protein	NA	NA	NA	NA
WP_035169384.1\|5653_6871_+	conjugal transfer protein TrbI	NA	NA	NA	NA
WP_080738667.1\|6867_7659_+	lytic transglycosylase domain-containing protein	NA	NA	NA	NA
WP_040126358.1\|7655_8036_+	single-stranded DNA-binding protein	F8TUL2	EBPR_podovirus	1.7e-06	34.7
WP_002850926.1\|8099_8738_+\|transposase	IS607-like element ISCfe1 family transposase	A0A1S5RGS9	Helicobacter_phage	2.9e-96	85.6
WP_171819451.1\|8724_10017_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	A0A1S5RFS3	Helicobacter_phage	6.5e-119	55.9
WP_080723873.1\|10012_11461_+	toprim domain-containing protein	H9C0J7	Bdellovibrio_phage	2.1e-17	28.0

DBSCAN-SWA_2

15327 : 18420

Helicobacter_phage(66.67%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010404252.1\|15327_16428_-\|transposase	transposase	G9CU70	Helicobacter_phage	1.3e-99	52.1
WP_010404250.1\|16405_16861_-\|transposase	IS200/IS605 family transposase	G9CU69	Helicobacter_phage	1.7e-66	82.3
WP_051945896.1\|16964_17255_+	S26 family signal peptidase	NA	NA	NA	NA
WP_002850989.1\|17251_17623_+	hypothetical protein	NA	NA	NA	NA
WP_002850991.1\|17733_18420_+	AAA family ATPase	A0A222YXS3	Escherichia_phage	3.8e-25	30.8

DBSCAN-SWA_3

23689 : 25223

Helicobacter_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_010404252.1\|23689_24790_-\|transposase	transposase	G9CU70	Helicobacter_phage	1.3e-99	52.1
WP_010404250.1\|24767_25223_-\|transposase	IS200/IS605 family transposase	G9CU69	Helicobacter_phage	1.7e-66	82.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP008810

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP008811

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. NZ_CP008812

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection