CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP049749	Rhodococcus fascians A21d2 plasmid pA21d2, complete sequence	0 crisprs	NA	0	0
NZ_CP049750	Rhodococcus fascians A21d2 plasmid unnamed1	0 crisprs	DEDDh	0	0
NZ_CP049748	Rhodococcus fascians A21d2 chromosome, complete genome	8 crisprs	csa3,WYL,cas3,cas4,DEDDh,DinG	1	2
NZ_CP049751	Rhodococcus fascians A21d2 plasmid unnamed2, complete sequence	0 crisprs	NA	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP049748_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049748_1

371229-371326

Orphan

Consensus_repeat	Method
GTGCAATGGTCCATTCACCCGGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049748_1

>merge|NZ_CP049748|1|371229-371326|CRISPRCasFinder
GTGCAATGGTCCATTCACCCGGACCGACCGGGCCACCCGCACCGCGTCGATGGCACTTTGCACACGTCTCGGCGGTGCAATGGTCCATTCACGCGGAC

>NZ_CP049748|1|1|371229-371326|CRISPRCasFinder
GTGCAATGGTCCATTCACCCGGAC	CGACCGGGCCACCCGCACCGCGTCGATGGCACTTTGCACACGTCTCGGCG
GTGCAATGGTCCATTCACGCGGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049748.1\|WP_080734479.1\|373671_374829_+\|PPE-domain-containing-protein	unknown	unknown	gnl\|CDD\|366325
NZ_CP049748.1\|WP_032401435.1\|375687_376353_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP049748.1\|WP_037152406.1\|374825_375650_+\|ESX-secretion-associated-protein-EspG	unknown	unknown	gnl\|CDD\|379414
NZ_CP049748.1\|WP_080734486.1\|369376_369709_+\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240572
NZ_CP049748.1\|WP_037152410.1\|373256_373568_+\|PE-family-protein	unknown	unknown	gnl\|CDD\|376422
NZ_CP049748.1\|WP_037152786.1\|366589_367843_-\|serine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235461
NZ_CP049748.1\|WP_037152416.1\|371332_372136_-\|CbtA-family-protein	unknown	unknown	gnl\|CDD\|378192
NZ_CP049748.1\|WP_037152783.1\|367854_368247_-\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NZ_CP049748.1\|WP_037152795.1\|362874_364329_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP049748.1\|WP_037152789.1\|365666_366545_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_037152401.1\|377291_378014_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_155292656.1\|361422_362067_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP049748.1\|WP_037152780.1\|368271_369363_+\|septum-formation-family-protein	unknown	unknown	gnl\|CDD\|379393
NZ_CP049748.1\|WP_037152413.1\|372603_373170_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP049748.1\|WP_032381051.1\|378131_378902_+\|DUF2470-domain-containing-protein	unknown	unknown	gnl\|CDD\|378456
NZ_CP049748.1\|WP_037152791.1\|364824_365565_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP049748.1\|WP_037152403.1\|376349_377282_-\|prephenate-dehydratase	unknown	unknown	gnl\|CDD\|237013
NZ_CP049748.1\|WP_052058601.1\|362194_362878_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP049748.1\|WP_037152793.1\|364329_364815_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP049748.1\|WP_032381168.1\|372126_372321_-\|CbtB-domain-containing-protein	unknown	unknown	gnl\|CDD\|370526

Protein	Function_ID	Function_description	E-value
NZ_CP049748.1\|WP_032401435.1\|375687_376353_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.87382e-41
NZ_CP049748.1\|WP_037152406.1\|374825_375650_+\|ESX-secretion-associated-protein-EspG	gnl\|CDD\|379414	pfam14011, ESX-1_EspG, EspG family. This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis. These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread. Proteins in this family are typically between 254 and 295 amino acids in length.	1.2137e-32
NZ_CP049748.1\|WP_080734486.1\|369376_369709_+\|metallopeptidase-family-protein	gnl\|CDD\|240572	cd12952, MMP_ACEL2062, Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein. The subfamily includes an uncharacterized protein from Acidothermus cellulolyticus (ACEL2062) and its homologs from bacteria. Although its biological role remains unclear, ACEL2062 contains a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets and a HExxHxxGxxD/S (x could be any amino acid) motif. It may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD motif.	4.08109e-36
NZ_CP049748.1\|WP_037152410.1\|373256_373568_+\|PE-family-protein	gnl\|CDD\|376422	pfam00934, PE, PE family. This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	1.84418e-08
NZ_CP049748.1\|WP_037152786.1\|366589_367843_-\|serine--tRNA-ligase	gnl\|CDD\|235461	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional.	0
NZ_CP049748.1\|WP_037152416.1\|371332_372136_-\|CbtA-family-protein	gnl\|CDD\|378192	pfam09490, CbtA, Probable cobalt transporter subunit (CbtA). This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of five transmembrane segments, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization with a small protein (CbtB) having a single additional transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site.	4.71597e-58
NZ_CP049748.1\|WP_037152783.1\|367854_368247_-\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	5.90865e-20
NZ_CP049748.1\|WP_037152795.1\|362874_364329_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.80158e-49
NZ_CP049748.1\|WP_080734479.1\|373671_374829_+\|PPE-domain-containing-protein	gnl\|CDD\|366325	pfam00823, PPE, PPE family. This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis.	2.51586e-14
NZ_CP049748.1\|WP_155292656.1\|361422_362067_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.75308e-06
NZ_CP049748.1\|WP_037152780.1\|368271_369363_+\|septum-formation-family-protein	gnl\|CDD\|379393	pfam13845, Septum_form, Septum formation. This domain is found in a protein which is predicted to play a role in septum formation during cell division.	1.63788e-94
NZ_CP049748.1\|WP_037152413.1\|372603_373170_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.157e-28
NZ_CP049748.1\|WP_032381051.1\|378131_378902_+\|DUF2470-domain-containing-protein	gnl\|CDD\|378456	pfam10615, DUF2470, Protein of unknown function (DUF2470). This family is a putative haem-iron utilisation family, as many members are annotated as being pyridoxamine 5'-phosphate oxidase-related, FMN-binding; however this could not be confirmed.	5.67049e-07
NZ_CP049748.1\|WP_037152791.1\|364824_365565_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	7.64071e-53
NZ_CP049748.1\|WP_037152403.1\|376349_377282_-\|prephenate-dehydratase	gnl\|CDD\|237013	PRK11898, PRK11898, prephenate dehydratase; Provisional.	1.43556e-113
NZ_CP049748.1\|WP_052058601.1\|362194_362878_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.28801e-64
NZ_CP049748.1\|WP_037152793.1\|364329_364815_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	5.75432e-19
NZ_CP049748.1\|WP_032381168.1\|372126_372321_-\|CbtB-domain-containing-protein	gnl\|CDD\|370526	pfam09489, CbtB, Probable cobalt transporter subunit (CbtB). This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization with a protein (CbtA) predicted to have five additional transmembrane segments.	4.39707e-08

>NZ_CP049748.1|WP_080734486.1|369376_369709_+|metallopeptidase-family-protein
MTRVDFEEAVSDALDTLPRELTDFMNNVVVLVEEEHPTEDILGLYEGIALTERYEYSGHLPDVITIYRKPILEMVDDETEARREIAITVAHEIGHHFGIDDERLHQLGFG
>NZ_CP049748.1|WP_037152780.1|368271_369363_+|septum-formation-family-protein
MEAMSANETDPPESRNRRTLSATTARRGLAMVAVGAVLAAGATAFLSDGFSAPEKITTHSAASGPVTDGPVSASSFGAADPGTCLQWTPTDDPETDRQDLAEVSCADPHRFEVARDIDMSVYPGVEFGPGSQYPGSIRFGQLRDEHCTAAVDDYVGAKFDPNGLFGVGLMFPSQAGWAKGERTLRCGVQMPSNTGALLEMTGSILEQDQSKVWPTGTCIGINQNVPADPVDCSAPHAFEVSSVINLTQQFPGGHPSEGDQDAYLEGTCTDAVNGYLGSDTALRDKTLTLFWDTIDVASWLAGSRQVTCSVGKELDSGGFATIVGSAKGDILINGAAPVPPPSAPDGRALPTPLPGAAPITTGG
>NZ_CP049748.1|WP_037152783.1|367854_368247_-|ankyrin-repeat-domain-containing-protein
MSDPTGDDDLSELAGRLFTMARTGDAAGLTSYVDAGVPVNLHNESGDTLVMLAAYHGHADAVRVLVERGADVNKPNDKGQTPLAGAVFKGEDDVVRVLVDGGADPHGGHPSAIDAATMFGREDYLGLLGK
>NZ_CP049748.1|WP_037152786.1|366589_367843_-|serine--tRNA-ligase
MIDLKFLRENPDAVRASQRTRGEDPALVDALLDADASRRAAVLAGDQLRAEQKALGKKVGKASAEDRPALLAGASELAAKVKAAQAAEAEADAALDTAHRAISNIVQDGTPAGGEDDFVLLETVGDIPEFDFEPKDHLELGESLNLIDMERGAKVSGSRFYFMTGYGALLQQGLLQLAAQKAVKNGFTMMIPPVLVRPEIMSGTGFLGAHADEIYRLEADDLYLVGTSEVALAGYHSGEIIDLADGPKRYAGWSSCFRREAGSYGKDTRGIIRVHQFDKIEMFSYIKPEDAAAEHQKLLEYEKEMLAAVELPYRVIDTAGGDLGSSAARKFDCEAWVPTQKAYRELTSTSNCTTFQARRLGVRYRDESGKPQIAATLNGTLATTRWIVAILENHQQADGTVRVPEALVPFVGTDVLR
>NZ_CP049748.1|WP_037152789.1|365666_366545_+|hypothetical-protein
MKNRAAPPRRSRVGRTALPLIATIALVGACDSAVGIPSDQAASPSNAVESTADESTTQESPSTTATTPMPPPIPPGPPVGEAPGNPAAAAALRPFVNDLTGGGIGVVTAKCWTVPPTDIPTMYVDTGAILAAVAAPAVDGQYAVTWTGPTATVAIKRSEITSGYACPTVYPTGTAPVFDAADAAYSVDRYLGRIAGIPVNRDDVEERYPLVCESRGTWDPNGTGSPTAPPLAQDPAILPSITSFDPDSVFVTAQNGIYTQVNADIIDASGAYQNRTFVLTVGGEGYCIGDIA
>NZ_CP049748.1|WP_037152791.1|364824_365565_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MEPVYRSVIGIARTVFAFEGLKFEVEGEEHIPATGGAVIAVNHTGYMDFTYAGLPPRRVKRYIRFMAKKEVFDNKISGPIMRALRHIPVDRGAGAESYKSAVESLRNGELVGVYPEATISRSFEIKEFKSGAARMAIEAGVPIIPTVIWGAQRVWTKGYPKRLGRTNTPISIAVGEPIAPVGPPNELTDKLRAVMQKMLLELQENYHHEPGAYWVPARLGGSAPTLEEADKLDAQDLAARAAKRAE
>NZ_CP049748.1|WP_037152793.1|364329_364815_-|GNAT-family-N-acetyltransferase
MNLRGERVVLRPVAAEDVPELRRILHTPEVYMRWGDEDADENWPFDDPEAVRMIVELDGAARGLIQYSEEPDPMYRHASIDIFLDPAVHGRGVGKDAVGTLVRYLTVDLGHHRLVIDPAADNAIAIACYSAVGFEPVGIMRKYEKGPDGWHDSLLMDLIVE
>NZ_CP049748.1|WP_037152795.1|362874_364329_+|HAMP-domain-containing-histidine-kinase
MKRTPTPSLRMRVVATVVVLFAVLLVIVGSSVDVVLGQQLRRDLEARLSDRSTRAVELVESGVGSEDLVQALQGDAIRVRVTAADGTVYGAPGGEPPAQDDRPAGPNPPSGPSNAPTPPGPPDPPAPPSDSLEITKPLPDGSTLSLLGDTTAIADVRRQLRILMLGAGAVTLLLAAAALTFAVRRALSPLDSMTSVARRITNGDRGRRLLPTKPNTDLGRTASAVDEMLDALEDAERREASAARTAKLAEEDMRRFLADAAHELRTPVAGISALAQSLQRDAEQRPDRVARWSELLVGESARASRLVSDMLDSVRAENTSDLELTDSDLADLTRRTVERAALLTPHIRFDIDAAQPVPVRVDVGRIEQILSNVLDNASRFTPRGGSITVAVNSVGNEAVVTVDDEGPGVPEADRERIFERLVRLNSARDRSSGGVGLGLSIARTLARAHNGELVCAAGPTGARFRLSLPGLTGRSAGSTPANGR
>NZ_CP049748.1|WP_052058601.1|362194_362878_+|response-regulator-transcription-factor
MTYSSAPRVMVVEDSLPIREALVAAFEDAGFTAASLPDGDDFETTMAGFRPDVVILDVMLPGARDGFALIDVVRQSTDAGIIMVTAKDQLADRLRGLSDGADDYVVKPFQLDEVVARAKSVLRRRGRSSDAVQVGDLLVDEPAGVVTRAGQVLDLTATELRLATFLVAQRGRTVSKTSILESVWGYGAYDGNLVEVHISALRRKMEAHGPRLIHTVRGLGYALRAPQ
>NZ_CP049748.1|WP_155292656.1|361422_362067_-|hypothetical-protein
MNDQTQPIPAASNPEPAPSAEADPTRANKPKRWKGRVPLAATAAAGLAVGALVTAAVFAATGPDVSPGVSTVASSSALGQRTDGGGGSDASTTPAAPESTDGSTAPAPADGATPPAPGDGATPPAPPAGGPGKGGPAEGGPGKGGPGAGGAVCAPEDGATPPAPPAEGDGATPPAPPAAPADGATPPAPADGATPPAPADGATPPAPPAAPSGS
>NZ_CP049748.1|WP_037152416.1|371332_372136_-|CbtA-family-protein
MPLTDTTHRPTLQGTFVQLLLRGLLAGLVAGLLAGAVAYVVGEPHIDSAIAIEEAAGTDAHHADADAAPAAHSHGDEEALVSRDGQRVGLFLATGLAGLALGAIFASALHYARRFSSLPGSILALVGAGAGWLAIEAVPFFKYPANPPAVGDPETITQRTWLWLASVILGLLAVGVGIYVAKVVASQNSVAVRVGAPIVAFLLIVGIGYALLPGINEVGADFPATLLWEFRLSSLATQATLWLALGLGFAFLTDRAVRPVRREAVAA
>NZ_CP049748.1|WP_032381168.1|372126_372321_-|CbtB-domain-containing-protein
MAITHSPSNTTESAALAVIVAATILLAFVVLYLVGFDQGAISRSGMYMHELMHDGRHLLGLPCH
>NZ_CP049748.1|WP_037152413.1|372603_373170_+|histidine-phosphatase-family-protein
MPASVTRLILVSHARTAAMRTGRFPGDEPLDDSGVRDLAAVTDIPRADRVLSGPESRSMATAQIFGTDISFEPALADIAYGRWSGLEMTDLPDADAMAWLSDPAFVPPGGESLVALFSRVQKWLEDVGSTPGRTLVVTSPAVIRAVVVLVLEAPVRSFWRVDVSPLSRTSVSRRGGAWTIGAVAEKSI
>NZ_CP049748.1|WP_037152410.1|373256_373568_+|PE-family-protein
MTVIKVDPVALQLAASELDAVAARLQAAVTTTAIPVRPLPPGTDEVSLLTERFFGTAADTFGPAAAQGISELHRAAEELRKQAADYVATDDDTAGGLPGLPGI
>NZ_CP049748.1|WP_080734479.1|373671_374829_+|PPE-domain-containing-protein
MVWLPRTATGNSTRLLGPGPVPLHVAGGAWGSVAAAFTEASASIAAVTAALTAGWEGDSALLAQAALARFATWTGATALKAAALSVEAPAAGTTYGVALATMPSLVEIGVVQAAKVTAASTGGALNGSYEAAEVADRLLDIRAALVMEGFELVNSHRIVKTTFDHPPAIVSDSGSGLGKFANAVMTSPVQAAIGGLMAATQNPGVAAAAGQIGSAATSIASTGVSTVATAASNIGSTALSGGSGVGGGHGFASNGSASLAVGPASTRPVSFGAGGAGLGGFGGVGMPGSAPSPAGGGSTLFGPGQSGPANAFGAPTAADGGLAQRGTGTAGAPASGARGQAEDDEHETPDYLKQFEHFADGRTVAPSVIGADPALPVPDTSGNGR
>NZ_CP049748.1|WP_037152406.1|374825_375650_+|ESX-secretion-associated-protein-EspG
MIDLGTVPVGHALPNAALGVDEMDFLVDELSIAELPVVLDVFPRFDDATARDRALGRGRDALDNVGLITGGRVHEDLQQWMRVLEQPHWYVSARVFDVESDEPAPTTRICVASDDRITVSAVRRENVVTIRVIHGDPARDLAVTIGPATPFDPGIVNAPTALLAQALDAAPSDVGATASRLSRIGIADDRASALASVMATCAGRTEITAVAPRHGTRHVAGRPVALFDTRAGRIVATSTLAADGTSWSSLTGATDRKVTAALTELIESAREHRV
>NZ_CP049748.1|WP_032401435.1|375687_376353_-|histidine-phosphatase-family-protein
MMGKLILVRHGQTKANVAKMLDTAPPGAELTELGHQQAESYARTWVGHPPAVLVSSIALRAKQTAGYIERATGVPLVVTEGIQETYAGDLEDRDDPAAHKEFTEVFHRWHTGDLAATVPGGDSGHSVLERYVPVLDALRAQYLGDDTAGDVVVVSHGAAIRLVAAVLAGVDGTFAADNHLDNTQTVELLPLPGGGWACGKWGTFLPPFEGQGSEKADNPIS
>NZ_CP049748.1|WP_037152403.1|376349_377282_-|prephenate-dehydratase
MPRIAYFGPSGTFTEMALAQFEKLGTIAAAGLDGAVERVTAASPPAALEAVRSGNADAAVVPIESSIEGAVPPTLDALSEGRRLQIVAETEIEVAFTILGGPGVTLDSARTISAYPIALNQVRQWLQATMPGAAVQSASSNAGAAEDVAAGMVDAAVSTRLAGERLSLPTLADGIIDVEGARTRFVLVTPPRPVAPRTGADRTAVVLEPPNDPGTLPAALAEFGIRNIDLTFIESRPTRSQFGTYRFFVDCAGHVEDPLVAEALTAFHRKMPLRFLGSWPIATGTGGSVPPPIDEHVQWLDDIRAGRGDL
>NZ_CP049748.1|WP_037152401.1|377291_378014_-|hypothetical-protein
MPIPLTLGVPHRPDPNALVHGLLLPICSDSVELNAAPQGAEYGPPVVRASTLLAMTDTADLGRIVVHLDIDPDELRASRTGGYEVVRFDVDAPAEHLADALALRLPSPLVVFPVFDAIDVAETAEAVVFAHRTPGISVADTPRRIADVLAVVSHADVGLVARADTGDDVLAILAATVASLRGDDISAALAAPNVAALRALIPEAAEAVREVLLGIEIADAVVARERLVEVGLIASRTSTT
>NZ_CP049748.1|WP_032381051.1|378131_378902_+|DUF2470-domain-containing-protein
MLGATTTTGPSTAERVRSACMRAEGAALAIDGSDPVVTSLHHLRPNGEMILAVPTDSLDDANTWQSSRAGIPAVLELTDHAPLALREPVRSLVWLRGDLRPVPESLMRPMAGAVAAEHPHAALLDVGHTTSLMRLIVSSAVVADSTGAEPVDVESLLAAEPDPFWEMETSWLEHLDSDHPDLLAQLSRRLPPSLRQGRIRPLGIDRYGIRLRIESDCGDNDVRLGFAEPVDDVLSLSRALRVLAGCPFLNGLRARG

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Crispr_ID: NZ_CP049748_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049748_2

560341-560595

Orphan

Consensus_repeat	Method
CAGGGCTACGACGCCCAGGGCTAC	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP049748_2

>merge|NZ_CP049748|2|560341-560595|CRISPRCasFinder
AACGGCTACGACGCCCAGGCCTACGCGCCTGCCGATTACGATCCGCGCTACGACCAGCAGCAGCCGTACAACGGTCAGGGCTACGACGAGCAGCAGTACGCCGAGCAGGGTCAGGCATACAGCGCGGCAGGCGGCCAGGACCAGGGTTACGACCCGCACGCCTACGGCAATGCCAACGGTCAGGACCAGGGCTACGACGCCCAGGGCTACAACTCGCAAGGCTATGACGCACAGGGGTACAACGCGCAGGGGTAC

>NZ_CP049748|2|2|560341-560595|CRISPRCasFinder
AACGGCTACGACGCCCAGGCCTAC	GCGCCTGCCGATTACGATCCGCGCTACGACCAGCAG
CAGCCGTACAACGGTCAGGGCTAC	GACGAGCAGCAGTACGCCGAGCAGGGTCAGGCATACAGCGCGGCAGGCGGCCAGGAC
CAGGGTTACGACCCGCACGCCTAC	GGCAATGCCAACGGTCAGGAC
CAGGGCTACGACGCCCAGGGCTAC	AACTCGCAAGGCTATGACGCA
CAGGGGTACAACGCGCAGGGGTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049748.1\|WP_032378772.1\|564668_566153_+\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|223839
NZ_CP049748.1\|WP_032378775.1\|561314_561779_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NZ_CP049748.1\|WP_037152158.1\|567532_569470_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP049748.1\|WP_032401647.1\|548486_549995_+\|phage-infection-protein	unknown	unknown	gnl\|CDD\|224428
NZ_CP049748.1\|WP_032401652.1\|561775_563218_+\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_CP049748.1\|WP_032378773.1\|563214_564672_+\|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl\|CDD\|223843
NZ_CP049748.1\|WP_037152596.1\|569478_570120_-\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|181107
NZ_CP049748.1\|WP_032378768.1\|571079_571343_+\|cell-division-protein-CrgA	unknown	unknown	gnl\|CDD\|178907
NZ_CP049748.1\|WP_037152156.1\|570133_570877_-\|DUF881-domain-containing-protein	unknown	unknown	gnl\|CDD\|377575
NZ_CP049748.1\|WP_094608943.1\|546868_547780_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176125
NZ_CP049748.1\|WP_032378780.1\|550324_551851_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NZ_CP049748.1\|WP_032378781.1\|549929_550226_-\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NZ_CP049748.1\|WP_032401649.1\|552935_554387_-\|glutamate-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|237213
NZ_CP049748.1\|WP_032401650.1\|554379_558969_-\|glutamate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236968
NZ_CP049748.1\|WP_032378779.1\|551829_552732_-\|cutinase-family-protein	unknown	unknown	gnl\|CDD\|366455
NZ_CP049748.1\|WP_052058543.1\|545079_545571_+\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|379388
NZ_CP049748.1\|WP_032401646.1\|547784_548399_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP049748.1\|WP_052058589.1\|545556_546786_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_CP049748.1\|WP_052058542.1\|571379_571865_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|371225
NZ_CP049748.1\|WP_032378771.1\|566159_567536_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916

Protein	Function_ID	Function_description	E-value
NZ_CP049748.1\|WP_032378772.1\|564668_566153_+\|penicillin-binding-protein-2	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	7.58139e-99
NZ_CP049748.1\|WP_032378775.1\|561314_561779_+\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	6.28884e-24
NZ_CP049748.1\|WP_037152158.1\|567532_569470_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.29533e-129
NZ_CP049748.1\|WP_032401647.1\|548486_549995_+\|phage-infection-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	1.26712e-12
NZ_CP049748.1\|WP_032401652.1\|561775_563218_+\|serine/threonine-protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	1.87072e-76
NZ_CP049748.1\|WP_032378773.1\|563214_564672_+\|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl\|CDD\|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	2.09639e-87
NZ_CP049748.1\|WP_037152596.1\|569478_570120_-\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|181107	PRK07765, PRK07765, aminodeoxychorismate/anthranilate synthase component II.	2.2411e-141
NZ_CP049748.1\|WP_032378768.1\|571079_571343_+\|cell-division-protein-CrgA	gnl\|CDD\|178907	PRK00159, PRK00159, putative septation inhibitor protein; Reviewed.	8.81934e-50
NZ_CP049748.1\|WP_037152156.1\|570133_570877_-\|DUF881-domain-containing-protein	gnl\|CDD\|377575	pfam05949, DUF881, Bacterial protein of unknown function (DUF881). This family consists of a series of hypothetical bacterial proteins. One of the family members YlxW from Bacillus subtilis is thought to be involved in cell division and sporulation.	4.02958e-49
NZ_CP049748.1\|WP_094608943.1\|546868_547780_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.37029e-68
NZ_CP049748.1\|WP_032378780.1\|550324_551851_+\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	5.89662e-93
NZ_CP049748.1\|WP_032378781.1\|549929_550226_-\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	4.16847e-27
NZ_CP049748.1\|WP_032401649.1\|552935_554387_-\|glutamate-synthase-subunit-beta	gnl\|CDD\|237213	PRK12810, gltD, glutamate synthase subunit beta; Reviewed.	0
NZ_CP049748.1\|WP_032401650.1\|554379_558969_-\|glutamate-synthase-large-subunit	gnl\|CDD\|236968	PRK11750, gltB, glutamate synthase subunit alpha; Provisional.	0
NZ_CP049748.1\|WP_032378779.1\|551829_552732_-\|cutinase-family-protein	gnl\|CDD\|366455	pfam01083, Cutinase, Cutinase.	3.40766e-07
NZ_CP049748.1\|WP_052058543.1\|545079_545571_+\|DUF4190-domain-containing-protein	gnl\|CDD\|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	3.72091e-24
NZ_CP049748.1\|WP_032401646.1\|547784_548399_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	5.61221e-35
NZ_CP049748.1\|WP_052058589.1\|545556_546786_-\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.80433e-64
NZ_CP049748.1\|WP_052058542.1\|571379_571865_+\|PH-domain-containing-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	4.78619e-06
NZ_CP049748.1\|WP_032378771.1\|566159_567536_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.16518e-115

>NZ_CP049748.1|WP_032401650.1|554379_558969_-|glutamate-synthase-large-subunit
MKHTPGPQGLYDPVNEHDSCGVAFVVDMHGRRSRDIVEKAITALVNLEHRGAAGSEPNTGDGAGILIQVPDAFFRAVVDFELPAPGAYATGVAFLPQGRSDAARACEGVERIVESEGLTVLGWREVPTDDSSLGALARDAMPTFRQLFLAAPDASVTDLDLERRAFVIRKRVEHELGEEGAGKDGPGRETVYFPSLSSQTFVYKGMLTTPQLKGFYLDLQDERVESALGLVHSRFSTNTFPSWPLAHPFRRVAHNGEINTATGNENWMRAREALITSDVFGGSEALEKIFPVVTHGASDTARFDEVLELLHLGGRSLPHAVLMMIPEAWERHESMDPARRAFYKYHSSLMEPWDGPASVCFTDGTVIGAVLDRNGLRPSRLWVTDDGLVVMASEVGVLDIDPSKVVRKVRLQPGRMFLVDTAQGRIVSDDEIKDELAAEHPYQQWLDEGLTSIDDLPERPHVHMPHDRVLIRQQIFGYTTEELNVLVSPMAKSGAEAIGSMGTDTPIAVLSARPRMLFDYFSQLFAQVTNPPLDAIREEIVTSLGGTIGPEGDLLNPDAESCKQIVLPQPILHNDDLAKLVHINDEGTQEELRSVVVRGLYPVAEGGEGLRKSLEAIRAQVSAAISGGARIIVLSDRESSEKLAPIPSLLLTSAVHHHLVREKTRTKVGLIIESGDAREVHHMALLIGFGAAAVNPYMAFESIEDMIERGALTGIEFDKAVGNYIKAAGKGVLKVMSKMGISTLASYTGAQLFQVIGLSQELVDEYFTGLNSHLGGIDLDQVADDVAARHAVAYLDNRQERAHRELETGGEYQWRREGEYHLFNPDTVFKLQHSTRTGQYDVFKEYTKMVDDQSERLASLRGLFRFKTEERQAISIDEVEPASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGGRSNSGEGGEDVSRFTPDENGDWRRSAVKQVASGRFGVTSHYLTNCTDIQIKMAQGAKPGEGGQLPAHKVYPWVAEVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANPEARIHVKLVSEVGVGTVAAGVSKAHADVVLISGHDGGTGATPLTSVKHAGGPWELGLAETQQTLLLNGLRDRIVVQVDGQLKTGRDVMVAALLGGEEFGFATAPLVVSGCIMMRVCHLDTCPVGVATQNPLLRKRFAGKPEFVENFFMFIAEEVRELMAELGFRTLDEAVGQVGLLDTTAAKEHWKASKLDLSPILEEVESAFMNQNLYNTGVQDHGLDKALDQQLIAASRNALDKGEKVVFESKITNVNRTVGTMLGHEVTKAYGGVGLPDDTIDITFTGSAGNSFGAFVPSGMTLRLQGDANDFVGKGLSGGHLVLRPSLSAPKGFVAEDNIIGGNVFLFGATSGEALIRGVVGERFAVRNSGAEAVVEGVGDHGCEYMTGGKVVILGTTGRNFGAGMSGGVAFIFDPNKTFEANLNTELVDIDELEGDEFTWLKDIVTRHQEQTGSEVAERILADWSQQVNHFVKVMPRDYKKVLLAISEAEKNGADVDEAIMEAARG
>NZ_CP049748.1|WP_032401649.1|552935_554387_-|glutamate-synthase-subunit-beta
MGDPQGFLKNTVREVPKRRPVDLRLMDWKEVYEDFSKDTLRTQASRCMDCGIPFCHNGCPLGNLIPEWNDLVFKDRWRDSIDRLHATNNFPEFTGRLCPAPCEASCVLGINQDPVTIKQVEVEIIDKAFEEGWVTPVYPTHLTGKTVAVVGSGPAGLAAAQQLTRAGHTVTVFERADRIGGLLRYGIPEFKMEKRHIDRRLAQMEAEGTVFRTNVDVGVDISADELREQFDAVVLSGGATAWRDLPIEGRELDGIYQAMEFLPHANRVQQGDFAAPPVSAEGKKVVIIGGGDTGADCLGTSHRQGAESVHQFEIMARPPEERATSTPWPTYPLMYRVASAHEEGGERVFSVNTERFVGEDGKVTALEACEVEFKAGKFEKVEGSEFTLEADLVLLAMGFVGPDKGGLLTDLGVDFNQRGNVERTNEWVTNVPGVFVAGDMGRGQSLIVWAIAEGRSCAAAVDTFLQGATALPSPIVPTQAPQR
>NZ_CP049748.1|WP_032378779.1|551829_552732_-|cutinase-family-protein
MSVKKICAGVGVAAAVASGLVVGASPAAADPGDCPSMYVVAIPGTWETSSGAAPKPGMLTDVTDRLGDDIRTDYVSYPATAFPWEGEVYGQSRAAAVTNAGGMLKAMADRCGATKLGIIGYSQGADAAGDLAAAIGTGVGVVPADKVVAVGLISDPKRSDTDALVGPAVVGTGVGGPRVGGFGYVSPVVRTFCAVGDLYCSTPKDDYVARLAGFLAVSSNPAPDVADQYSQEAQSLIADLAAAGGLPVLQGQLTDQANEQRSREIEAFYRSGIHQEYQSYDVDNGQSATRWLARYLSDAV
>NZ_CP049748.1|WP_032378780.1|550324_551851_+|MFS-transporter
MSHRTTEQRATKKDWLGLAVLVVPILVVSMDMSVLYLALPFMTADLEPTSNQTLWILDIYGFLLAGLLITMGSLGDRIGRRTLLMIGAVVFGAASLAATFSTSPEMLLVARALLGIGGATIAPSTLSLIRNMFHDPAQRKEAIGLWTAGFAGGAAVGPVIGGVLLEHFWWGSVFLINIPIMVVLFVAAPLLVPEFKDSDPGRFDPISVILAISSMLSIVYAIKHGAQEGIDAATITTAVLGLALGTVFVIRQRKAANPLIDVTLFAERAFSAAVVVQFLVIFAMTGFSLFASQYLQLVVGLGPLEAGLWLLIPAVAAAAGAVLAPTLSKVIRTGTIIAGGLLFIAFGCAAMVFVAADSGLPLLLTGMALLTFGIGAASTLNSDIVLTAAAPEKAGAASALSETGAELGGAVGIAILGTIGSTVYRHRMEDVIPVGTPAEIADPARETIGGAIAVADYLPEPFGSQLTAVANSSFIDGFNLAAGWSAGLMAVSAVAVFVLLRRQTASER
>NZ_CP049748.1|WP_032378781.1|549929_550226_-|antibiotic-biosynthesis-monooxygenase
MSNDLQVVATIIAKPDAIDAVRDGLSALVAETRKEEGNISYELFESAVEPGTFVTVELWKSQEDLDGHMQTPHLQQALSEFGAHLAAPPAIHPLRPVG
>NZ_CP049748.1|WP_032401647.1|548486_549995_+|phage-infection-protein
MGELRIFRRPAVALTALAFPLVAVGAFALGTGYDLGGESATETTTVAADTEQAPASEQASADPLAAARTSLNSASLPITFLSSGIGQLTAGGTQLNDGVGQLADGITQAHDGTIQLADGFGQYRDGIGQLGDGASQISGGVDQVVDQLAGFGALQADFTAKLAATADQVDRFPHPGSDAISGEIRGVIDTLNTQAFGPDTLAQLQTLKGGAQQLSTELNDPNSQFLGATAQLGDATVQLRDGLGQLDDGGQQLKAGTDQLVTSVKPVEGIVNGIATNVRDASAALPQGAAAATDGATADQNVAATSTSTGTGATPYLIAALVALGALGCVSLVRVLGRDTKPRWLAVGAAVAAVGISAAFAFAFATDAAIGPVIGAGVFLIVSAAAYLAAAGAIQRVLGAVVGQIVNVVALAVQVVVCGFAYASTAPIWGDLAAFMPMSYTAAGARIIASGEMSGTGWLAIGATVALLAVSALVYVSARGDSADGPERVDSGRGREMGTELA
>NZ_CP049748.1|WP_032401646.1|547784_548399_+|histidine-phosphatase-family-protein
MQLVLVRHALPQRSETSADPALAELGVEQSRRVPDAVARFPISRVVASSQLRAVQTAQPLADRLGLTVEPDERLTEYDRDFGGYVPIETAKTEFREAFDRIKAGHLPEQVDEHAFRQRVLAGVADIVSAGRHNDTVALFAHGGVINILLQDILHTPKVLGFPIDYCSVTRILFSRSGARSVSSVNETEHVWDLLPRNRQSTETS
>NZ_CP049748.1|WP_094608943.1|546868_547780_+|LysR-family-transcriptional-regulator
MRRETIELLPLLPTLVAVADTEHITDAAHVLGVPQPTVSRQVARASAILGVDIVERRGRGIVLTSAGRVLIPYLQRALSDLDAGIDAMTEHDARARGRIAVAFQNTLGEDVVPALIRQFRVDHPAVTFDLDQGARARCLERLADGVSDLAFVSLSAEHTDANSFQLYDERLMLVVPSDHRFASRRTVDLADTADENYIAMGHGFGMRSICDELWADAGFSPRIAFEGQDTHTVRGLVGAGLGIAILPRIRAHGGEGGTVDIGLTQPAARRRIGMVWNPRADLPRQVASFRAMVQRSGRTLVIR
>NZ_CP049748.1|WP_052058589.1|545556_546786_-|MFS-transporter
MTTTRTDVLEWEGHPRGSREYRRLVLALLFAGVATFAQLYSVQGILPLIAANLDITPSQSSLAVGLATVGVAVSVIPWSVAADRVGRVRAMTASILVATTLGLLVPLSPSLEVLLVVRFFEGAALGGLPAIAIAYLSEEVHRSHTALAAATYVSGTTLGGLLGRIVAGPVAEYTNWRIGTLTVSFIAALAAALFVWLAPKPRTTLAHSEIRDLPSRLWVNLREPGMLALYGQGFLLMGGFVAIYNFLGFRLEAVPFGLPQSLISLIFVAYLSGTVSSRVGGKLATKHGRSAVLAGATATMIVGVALTMASNLAVILIGLVILTMGFFAAHAIASGWTGQRAVHGRAQATSLYNLFYYGGSSIVGWLGGVVFQSLGWNALALFVIALAVVAGIWAACLGGRLARPVSVGR
>NZ_CP049748.1|WP_052058543.1|545079_545571_+|DUF4190-domain-containing-protein
MVNPQTEGSDPFDASDKDQPYPGQQQYPPYQNPQYQNPQYQNPEFQNPQYVNTQYQNPQYPNPQYGNAPYAGGGYQTPAPTNTLAIVSLVLAILGLTFLPLIASVCAVVCGHLSRGQIKRTGEGGSGFATAGLVVGYVSIALFVIVVGAIILFAVAASTSSTY
>NZ_CP049748.1|WP_032378775.1|561314_561779_+|FHA-domain-containing-protein
MQGLILQLTRAGFLLLLWFFVWAVLRTLRSDIYAAAGMRVPARYTGGSKVLPSFNKQKVAKYLVVTQGGLAGTRISLGTQPVLIGRADDSTLVLTDDYSSTRHARLSPRGGDWYVEDLGSTNGTYLDRAKVTTAVRVPLGTPVRVGKTVIELRP
>NZ_CP049748.1|WP_032401652.1|561775_563218_+|serine/threonine-protein-phosphatase
MTLVLRYAARSDRGLVRSNNEDSVYAGARLLALADGMGGHAAGEVASQLMIAALAHLDDDEPGEDLLGKLEAATREGNASIADQVEDEPELDGMGTTLTAILFAGKRIGLVHIGDSRAYMLRDGSLTQITRDDTFVQSLVDEGRITAEQAHTHPQRSLIMRALTGNEIEPTLTVREVRAGDRYLLCSDGLSDVVSDETIENTMNEGETGPCADRLIELALRSGGPDNVTVVVADVIDLDYGQSHPILGGAASTEDEEDAPPPNTAAGRAAAMRPPRSTPKRVTTPVVTPEKKSHKLRWTLIALTLVVLAAIGALVANSIIRGNYYVGADNSKVTVLRGLPGSVLGYSLQSVELTGCLDGDGAVTLTAPDAEPADCVPFEIDDLLPAAREQVTAGLPSGSLDDARGQVQRLASGDLLPVCETEPAVTTTTPEPTPTTIIPPPGVPLPPTAEPVPEAAPTTTAVPTPTVPQVPGQNCRTGTR
>NZ_CP049748.1|WP_032378773.1|563214_564672_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MSSPTSAGGSFPSPPGGFAPAPIQSNRRGVELLLLGAAVLITTISLVLVEASQEQTITWDLAKYALAYLALMTVAHLAVRRFAPHADPLLLPIVALLNGLGLVLIHRLDLADQQQAQYLGNPIPSPDANQQVLWTTLAIAGFVALLVLLRDYRTLARYGYTVGLAGLILLAIPAMLPSAFSEVNGSKIWIRLPGFSIQPGEFAKILLLIFFASLLVAKRELFTVAGKHVLGMDFPRARDLGPILVVWVVSVAVLVFEKDLGTSLLIFGTVLVMIYIATERVGWLIIGFGLLIVGFLFAYQVFGHVKIRTDTWLHPFDDYNDTGYQIVQSMFSFATGGLAGTGLGSGRPSQVPFAKTDFIIATVGEELGLIGLTAVLILYLLFIIRGMRTALAVRDSFGKLLAAGLSFTIAIQLFVVVGGVTKLIPLTGLTTPYLSYGGSSLLANYLLLALLIKISDAAREPATPKKKPAPAAPIADAPTEMVKRP
>NZ_CP049748.1|WP_032378772.1|564668_566153_+|penicillin-binding-protein-2
MNTPLRRVSIAVMVMVVALLANATYLQVIKADDLRTDPRNSRVLLDEYSRQRGQISAGGQVLASSVATDDRYKYLRTYPQNSISPASPQANAPITGYYSMLYSSNGLERAEDPVLNGSDDRLFGGRLFDLISGRDPRGGNVVTTIDPVVQQVAYDQLTAKGYTGSVVALDPATGNILAMASTPSYDPNLLASHDGSTTTTAWENLSNDPNKPMVNRAISQTYPPGSTFKVITTAAALEAGATPDTQLTAASNITLPGTSTTLENYNGSTCGGGQTASLREAFARSCNTAFVELGIDTGVDKMRDAAAAFGIGEDTSIPLPVADSTIGPIDDDAALGQSSIGQRDVALTPLQDAVIAATVANGGVRMAPNLVQQLQSPDLSDLSSYQPKSMGEAISSDTAATLTDLMIGSENNTSGEGKIPGVQIASKTGTAEHGSDPRNTPPHAWYIGFAPANDPKVAIAVIVEDGGDRALAATGGSVAAPIGRAVIAAALQGR
>NZ_CP049748.1|WP_032378771.1|566159_567536_+|serine/threonine-protein-kinase
MPLSNGAVIAQRYRLLRLIATGGMGQVWEAMDNRLDRRVAVKVLKAEFSEDPEFLQRFRFEARTTAQLNYPGIAGVYDYGETRDGAGESLAYLVMELVNGEPLNAVLGRMSRLPLGHALDMLEQTGRALQIAHTAGVVHRDVKPGNILITPTGQVKITDFGIAKAVDASPVTKTGMVMGTAQYIAPEQALGEEATSASDVYSLGVVGYEVLAGTRPFVGDGALTVAMKHVREQPAPMPVDLPPAVRELIEITMVKDPATRYANGGEFADAVAAVRAGRRPPAPGNSRGSGTGRVMMPGVVPSPQPPPPSSTQMMPTSQREYRGPATGTAAAAVPEPTGMSSAQKALAWGGGALLLLAILIGGYVLLTGGRDDTQTPFVPPTTTTQPVTTTRTTTEPTTTTTEETTTEETTTTTTTTTTEPTTTTTSPTTTSEEPTQTTTTTPRPLFENPFQQEPQGQR
>NZ_CP049748.1|WP_037152158.1|567532_569470_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MTTPRTLSSRYELGEILGFGGMSEVHLARDTRLDRDVAIKVLRADLARDPTFYLRFRREAQNAAALNHPAIVAVYDTGEAETEAGPLPFIVMEYVDGDTLRDIVRAEGPMPPRRAMEVIADVCAALDFSHRNGIVHRDVKPANIMINNAGAVKVMDFGIARAIADSSSPMTQTAAVIGTAQYLSPEQARGEQVDARSDVYSLGCVLFEILTGEPPFKGDSPVAVAYQHVREDPQLPSLVNDTVPRELDSIILKAMAKNPANRYQSAAEMRTDLVRVLGGQRPSAPMVMNDEDRTTILGSVDSRQADFSGRDKPAAAAEASRPSRHAGPDDERQSRRGLKIGLVSVAAVIVVAIVGAFLWSLGPGADPKTVTVPTVVGLAADEAQRQLEDVGLRVTIQEKPDASVPEGSAIGTNPAAGSQTESPGAISLDVSSGPQQVQVPRLTGRTQQQASDALNEVGLELDPTIARAPSTPENLDKVVEQNPSSGVSMNANSQVRITLGSGPAQVRMPNVVGQLVDVAQPNVEGAGLRVQVQNIDSSQPVGQVVSTDPAGGTNVAENTVVTLRVSNGDKIPMPDLSGLTEAQALTALESAGWTGTASNLSTSRQSTLDPLMVGRIVNQTQPAGSEISKTDTISVSIGALGIPTG
>NZ_CP049748.1|WP_037152596.1|569478_570120_-|aminodeoxychorismate/anthranilate-synthase-component-II
MRILVVDNYDSFVFNLVQYLGQLNVDVEVWRNDDERLTDRDAVAAQFDGILLSPGPGTPQRAGATMDLVSAAARAKTPLLGVCLGHQAIGAVFGATVEKAPELLHGKTSLVHHSGVGVLEGMNDPFTATRYHSLTVRADTIPAELEVIGRTESGLVMAMRHTELPIHGVQFHPESILTEGGHRMLANWLAVCGMPADSGLVAKLEAQVSEAFA
>NZ_CP049748.1|WP_037152156.1|570133_570877_-|DUF881-domain-containing-protein
MTRRSTRADTRWWVLAVAVCAVVGLLLGTTRHISDGTELRSGDTTRLADLVDAARGSSEDAQRSRDALEQQVDTIQQRTASGDTDVADALARIDSLADAAGREAASGAGLTVTMADASRGPDGAYASDASPNDLVVHQVDVQSVLNALWAGGASAIAMQDQRLVASSAPRCIGNTLLLGGRTYSPPYVMTAIGDQDRLRAALKNEPGVRLYEQYALRYGLRYDVETSSDVSVPAYTESVRMRYAQPR
>NZ_CP049748.1|WP_032378768.1|571079_571343_+|cell-division-protein-CrgA
MPKSKVRKKNDYTINPANRTPVKVNAGPSPVWYVVLMLGFMLVGLLWLIVYYLAADDIAFIGNLGAYNFLIGFGFMVVGLVMTMRWR
>NZ_CP049748.1|WP_052058542.1|571379_571865_+|PH-domain-containing-protein
MWINPVDNFSNDPQGVYEERWATPVVAIAALVVGGFALGIGAVLSSTDAAGTFLVGLAAVGMWVIAALAAAQRPRLAITRDGSLTMKRLGGIRTYSRADIVRVKIVRYPRLGRRVPMLELDIRPPGEDDDRLIIFGRWDLGTDPRDVFDALDTHGLVPPNS

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Crispr_ID: NZ_CP049748_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049748_3

918081-918167

Orphan

Consensus_repeat	Method
CGCGGGGCATCGCTGCGTGAATG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049748_3

>merge|NZ_CP049748|3|918081-918167|CRISPRCasFinder
CGCGGGGCATCGCTGCGTGAATGGGCCATTGCATCGCCGAGACGTGTGGAGTGGTTCATTCACGCGCGGGGCATCGCTGCGTGAATG

>NZ_CP049748|3|3|918081-918167|CRISPRCasFinder
CGCGGGGCATCGCTGCGTGAATG	GGCCATTGCATCGCCGAGACGTGTGGAGTGGTTCATTCACG
CGCGGGGCATCGCTGCGTGAATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049748.1\|WP_032402140.1\|914321_914978_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_032402143.1\|909367_910795_-\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|153251
NZ_CP049748.1\|WP_037151727.1\|915870_918030_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NZ_CP049748.1\|WP_037151734.1\|905174_906446_+\|MSMEG_0569-family-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274942
NZ_CP049748.1\|WP_037151712.1\|927014_928100_+\|DNA-polymerase-domain-containing-protein	unknown	unknown	gnl\|CDD\|240135
NZ_CP049748.1\|WP_032402859.1\|925255_925858_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_080734426.1\|915063_915735_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP049748.1\|WP_037151725.1\|920201_921203_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|184853
NZ_CP049748.1\|WP_032402142.1\|910791_913089_-\|glycerol-3-phosphate-1-O-acyltransferase	unknown	unknown	gnl\|CDD\|179567
NZ_CP049748.1\|WP_037151732.1\|907300_908362_+\|MSMEG_0565-family-glycosyltransferase	unknown	unknown	gnl\|CDD\|274943
NZ_CP049748.1\|WP_037151716.1\|922945_923824_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP049748.1\|WP_032402847.1\|918252_919980_-\|dihydroxy-acid-dehydratase	unknown	unknown	gnl\|CDD\|234861
NZ_CP049748.1\|WP_032378544.1\|908343_909375_-\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NZ_CP049748.1\|WP_037151714.1\|923825_925259_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP049748.1\|WP_037151719.1\|922077_922896_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378988
NZ_CP049748.1\|WP_037151722.1\|921199_922081_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP049748.1\|WP_037151709.1\|928185_930042_-\|Na+/H+-antiporter-NhaA	unknown	unknown	gnl\|CDD\|377746
NZ_CP049748.1\|WP_037151729.1\|913526_914255_+\|translation-initiation-factor	unknown	unknown	gnl\|CDD\|184918
NZ_CP049748.1\|WP_032402858.1\|925962_927012_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|236191
NZ_CP049748.1\|WP_032402146.1\|906452_907304_+\|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|143587

Protein	Function_ID	Function_description	E-value
NZ_CP049748.1\|WP_032402143.1\|909367_910795_-\|HAD-IB-family-hydrolase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	8.65135e-53
NZ_CP049748.1\|WP_037151727.1\|915870_918030_+\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	1.74325e-61
NZ_CP049748.1\|WP_037151734.1\|905174_906446_+\|MSMEG_0569-family-flavin-dependent-oxidoreductase	gnl\|CDD\|274942	TIGR04046, predicted_flavoprotein_involved_in_K+_transport, flavin-dependent oxidoreductase, MSMEG_0569 family. Members of this protein family belong to a conserved seven-gene biosynthetic cluster found sparsely in Cyanobacteria, Proteobacteria, and Actinobacteria. Distant homologies to characterized proteins suggest that members are enzymes dependent on a flavinoid cofactor.	0
NZ_CP049748.1\|WP_037151712.1\|927014_928100_+\|DNA-polymerase-domain-containing-protein	gnl\|CDD\|240135	cd04865, LigD_Pol_like_2, LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The Pol domains of PaeLigD and Mycobacterium tuberculosis (Mt)LigD are stimulated by manganese, are error-prone, and prefer adding rNTPs to dNTPs in vitro; however PaeLigD and MtLigD belong to other subgroups, proteins in this subgroup await functional characterization.	1.25196e-121
NZ_CP049748.1\|WP_080734426.1\|915063_915735_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.72787e-05
NZ_CP049748.1\|WP_037151725.1\|920201_921203_+\|hypothetical-protein	gnl\|CDD\|184853	PRK14851, PRK14851, hypothetical protein; Provisional.	7.61926e-12
NZ_CP049748.1\|WP_032402142.1\|910791_913089_-\|glycerol-3-phosphate-1-O-acyltransferase	gnl\|CDD\|179567	PRK03355, PRK03355, glycerol-3-phosphate 1-O-acyltransferase.	0
NZ_CP049748.1\|WP_037151732.1\|907300_908362_+\|MSMEG_0565-family-glycosyltransferase	gnl\|CDD\|274943	TIGR04047, MSMEG_0565_glyc, glycosyltransferase, MSMEG_0565 family. A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity].	8.54637e-147
NZ_CP049748.1\|WP_037151716.1\|922945_923824_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	5.8281e-23
NZ_CP049748.1\|WP_032402847.1\|918252_919980_-\|dihydroxy-acid-dehydratase	gnl\|CDD\|234861	PRK00911, PRK00911, dihydroxy-acid dehydratase; Provisional.	0
NZ_CP049748.1\|WP_032378544.1\|908343_909375_-\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	3.37752e-30
NZ_CP049748.1\|WP_037151714.1\|923825_925259_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.26086e-72
NZ_CP049748.1\|WP_037151719.1\|922077_922896_+\|hypothetical-protein	gnl\|CDD\|378988	pfam12900, Pyridox_ox_2, Pyridoxamine 5'-phosphate oxidase. Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyzes the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.	0.00494222
NZ_CP049748.1\|WP_037151722.1\|921199_922081_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	2.33883e-22
NZ_CP049748.1\|WP_037151709.1\|928185_930042_-\|Na+/H+-antiporter-NhaA	gnl\|CDD\|377746	pfam06965, Na_H_antiport_1, Na+/H+ antiporter 1. This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyze the exchange of H+ for Na+ in a manner that is highly dependent on the pH.	2.05052e-172
NZ_CP049748.1\|WP_037151729.1\|913526_914255_+\|translation-initiation-factor	gnl\|CDD\|184918	PRK14954, PRK14954, DNA polymerase III subunits gamma and tau; Provisional.	1.28841e-05
NZ_CP049748.1\|WP_032402858.1\|925962_927012_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|236191	PRK08224, ligC, ATP-dependent DNA ligase; Reviewed.	0
NZ_CP049748.1\|WP_032402146.1\|906452_907304_+\|carbon-nitrogen-hydrolase-family-protein	gnl\|CDD\|143587	cd07197, nitrilase, Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes. This superfamily (also known as the C-N hydrolase superfamily) contains hydrolases that break carbon-nitrogen bonds; it includes nitrilases, cyanide dihydratases, aliphatic amidases, N-terminal amidases, beta-ureidopropionases, biotinidases, pantotheinase, N-carbamyl-D-amino acid amidohydrolases, the glutaminase domain of glutamine-dependent NAD+ synthetase, apolipoprotein N-acyltransferases, and N-carbamoylputrescine amidohydrolases, among others. These enzymes depend on a Glu-Lys-Cys catalytic triad, and work through a thiol acylenzyme intermediate. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. These oligomers include dimers, tetramers, hexamers, octamers, tetradecamers, octadecamers, as well as variable length helical arrangements and homo-oligomeric spirals. These proteins have roles in vitamin and co-enzyme metabolism, in detoxifying small molecules, in the synthesis of signaling molecules, and in the post-translational modification of proteins. They are used industrially, as biocatalysts in the fine chemical and pharmaceutical industry, in cyanide remediation, and in the treatment of toxic effluent. This superfamily has been classified previously in the literature, based on global and structure-based sequence analysis, into thirteen different enzyme classes (referred to as 1-13). This hierarchy includes those thirteen classes and a few additional subfamilies. A putative distant relative, the plasmid-borne TraB family, has not been included in the hierarchy.	1.15262e-61

>NZ_CP049748.1|WP_037151727.1|915870_918030_+|MFS-transporter
MTLLAMTPVQDMHKPYSRRWSALVVLCLSLLIVVMANTSLLVAAPSMTLDLSLTSSDLQWVIDGYTVPYASLMLLCGVIGDRYSRRGALILGLIIFVAGSIAGALTDATLGVILARIVMGVAAAIVMPATLSLLVATFPKRERATAVTVWAATSGLAIAAGPLLAGWLLESFTWHSTFLINVPIALAAIVGAVVLVPPSRAVDPGAIDWVGGLLSVLAVSTVVYAIIEGMHFGWTVGPLYFALVGLLSIVGFVGWEMRHPNPLLDVRMFSSRILSGATLAVLVFFLVTFGAIYFVAQYLQFALGYGPVSTGVHLLPLAGAVFVGSGITMWLTPKLGPRITVTAGMVVGTLSVVSLIGIDPTATYSDFLPVLTLLGLAIGLSVSPCTDAIMGEFPDSKLGVGGGLNDTALELGGSLGIAVLGSVLAASYRQGIEGFLQTFPGKQPNGQYTGQAAEGLAASQDSLAGAVIVSDIIRAQNAFLSGFADNLQANAVAAFGDAVTHTSLVAAVVFGVGTVIVALLIPSRSAALATSSERIPFEPIVPFVVPPAKDGAADREVAELEQLLERPSAAKVEKPSARHALRAAEEDTPKVVPKTVPTRTVAEPALVDAELERPSIYQLASKVYELDASVARQARVDAKSGERVTIHQLALSNLARTRRVEAEEALDAALELSDLSVAPAPEPVQPAAPLQTFYQRASKQHANCTEFKERSSSMWAMPL
>NZ_CP049748.1|WP_080734426.1|915063_915735_-|TetR/AcrR-family-transcriptional-regulator
MRKTTESTSTARGAAAPPVQRRDARSNRARILDVAQRVLADNPDATINDVAAAAGVVRRTVYAHFASREALIDGIALEAADSISAALGRVPAADESAVTVFVRQTLALTRVGDQYRLLLAVARTDLGHNGIHNLLGPMREAAAAVIRRGQREGVFSSYQAAEVLILNIEAIALSILDATNAGLLTDPAGAATTSSLVLLGIAPEDAERIVADVRASDSSARAR
>NZ_CP049748.1|WP_032402140.1|914321_914978_+|hypothetical-protein
MFKKFMLVVVGAAAIVASVGVGTASAAAPAALGGGSGIIVGGQAECTLTTIGNDRSGNLVGFTAGHCGRAGDSIVPEYDTSLGEVGRIAFSNPEYDYAVIEFQRDKVAPISRVGNVTISQVGPPTAFPNIVCKEGRTTGNTCGLAYGDILQSQETWAQLCVVEGDSGSPVVVGNTLVGMVNAYLGVACFGPEVGTNFDAILRNVDQGNGLGAGFVPAP
>NZ_CP049748.1|WP_037151729.1|913526_914255_+|translation-initiation-factor
MPPRGRAVNDSLTPENLTTLAAALAEGRRATVYLREPNPSLGLSDGTSAKVISIDGTTVTISPKGVNDELPYEAEELRITRNAATPPAPAKRVPAKKVAPPVSAAPARAEAVAAKPTTGPARAKAVVEQPKAVVEPPRAQPQQQAPRRGKKAPGGVSVTIHAGADNDWSVTVTQGAKRPTKAQPVSPESVSRAVRELGDPIARDAVEAVISHAREEAARRVAELSRQLEEARTTLAALEQDV
>NZ_CP049748.1|WP_032402142.1|910791_913089_-|glycerol-3-phosphate-1-O-acyltransferase
MYHLDADEQSLSDGPHVYLLDAKSTLEVQALNQWIDATTPDGEPRPPSVVLSGEARTSLAESVRGYADDPLLIPLRVTLSDRKNGILHRIFAPRGRSKPTQVWQRWVANDDPDHSAVLVGEPATLRDLQDRFERGGGTSLSSFILRQASLALDKAERGVIGSEYKIPRFVVEDMTEQKKFHDGITALADEVGQDRDAVDKRVNDILGEMVATETRRAVEMWGTLGAYFSRAYKVDVDRDQLQKVRELNKNYPLVFLPNHRSYLDPLVLRPALLAEGLPLNHVMGGINVGFWPLGPIAKRSGVVLIQRKFSDAIYKWTLRQYMSFLLSKRFNLEWYIEGGRSRTGKLRPPRFGLLTYLVDALESSDAEDVYLVPTSITYDRLHEVGAMAEESHGAKKQAEGIRMAIGYIRAQGTLRGNVYLNFGEPMSVASIVAENTDKRVAVQKIALGVSHAINDATPVTPAALVTMALLGIEDRALNVNEMWAIIAPLARYIKRRNLPTAGGVDIADVDVVRSAVVAQVNANVVKRFDDGPEPLFYLAQDKHLVAAFFRNNAIHFFVMRAIGELVVLPTSGDSAPLTQESLWQSALQLRDLLKFEFFFGDKKDFGQRLESEVDLIDPDWRTKISDPDYAAHQLQSQDLHLAHRVLQPIFEAYQVVADQLMLLPQSGEFDKPKFIAECLGAAQARRLRQQLDHSESISGELFDTALQLAENRDLVDSGSDGVARRRRDFALEIDEWARKVRTIRDMAHQMLRAVEPISAPEENNS
>NZ_CP049748.1|WP_032402143.1|909367_910795_-|HAD-IB-family-hydrolase
MTEFDDRLIAIAAAPPGRDTVAFFDLDGTLINGFSARAVFLERLKTLDVTVKELWEISSAVVEMRMRNSPVDNLMGKAVRGLEGRREDDLMEQAYTLFRNEIAPMIYPQARALVEAHRHAGHRLVMATSATPYQALPVQQDMMFEELLCTTPVVTDGILTGELVGDSLWGPRKAQAAIDYAEREGIALAGCFAYSNGGEDVPLLEAVGRPVALNPDPDLARYAAKKKWPALTLESPKRGTDITSAVRSTAALGSVLASASIGLGLGILTRSRRTGANITSTIAPDIALTLAGVKLDVTGTENAWSARPAVFMFNHQSTADSIIVTSILRRDITAVAKRELERDPRFALLGRIFDVAYVDRGDPSQAREAMRPAIDKLHSGISVAIAPEGTRMPTSRLGRFKKGGFHLAMQAGVPIVPIVIHNAGDVMWKKDFTVHSGTVKVTVGEPIPTTDWEPDKIDEYVDDVRSYFDRTLGYA
>NZ_CP049748.1|WP_032378544.1|908343_909375_-|adenylate/guanylate-cyclase-domain-containing-protein
MPENQINSVVQTEIERNLLGGEPKYNRADIVEKSGIPLERVIALWIGMGFPIHTDTEALVYTDADLEALKLITALTAQKVIKPEMEVAIARTLGQSMSRLAEWQVGVVNSHILERIIDSDEDKNDIDAIRRNARAIAAETVPTLEALQGYTWRRHLAAAAGRSIAAPDDATDSPTMAVGFADMVGYTSLTRRLDIGELTTLLEEFESLATNIIARGRGSVIKNVGDEVMFSAQTPEDAAHIALDLQDAFDEQEDMPDLRVGLAWGPVLARYGDLYGSVVNIAARLTSSANPGTTLVDTVMTEELRHDSEFYLKSIRSLRVKGFHKLKPHALRRNKRGGHKSEE
>NZ_CP049748.1|WP_037151732.1|907300_908362_+|MSMEG_0565-family-glycosyltransferase
MKIALLTYSSKPRGGVVHTLALAEALARSGQDVSVWSLGRGGDSEFFRTVDPAVTVRMVPFPQRENESVGQRILRSIDVLRQAFTPDRYDIVHAQDCISANAVGRCIRTIHHLDEFTTPELAACHERAITAPYARICVSAAVASDVRRGWGLEPTVIPNGVDAERFTAAAQSGRTHWRDKLGRYVLAVGGIEPRKGTLDLLDAFAGLSERNVQLVFAGGETLFDYRDYRAEFDRRAAELGIEPVILGTVDDDELPHLVAQSAVLPFFSTKEGFGLAAMEALAASIPVVARDLPVLREVFGDSVTYASSVEAMSSELDRALHEPRDPLPGLALARSLTWDEAARRHLGFYSSLL
>NZ_CP049748.1|WP_032402146.1|906452_907304_+|carbon-nitrogen-hydrolase-family-protein
MAPIKIGALAAHFGRDVDRAVLKITTIMSSAAREGIDLLVLPDASLGGYIDSLSNPDPAELPPTLDPDGPELAAIIAAAGDMTVCIGYTELSKGLRYNAAACLTGDGILGSHRKVHQPLGESLAYAAGDRFEAFDTPVGRMGMLIDYDKTFPESARALALDGARIIAALSAWPASVTDRASSLPNDRQSRLFDLYDAARAAENQVVLVSSNQTGVMGSLRFLGQAKIVGPGGDVLAKTWSKGGLAVHEIDVDAEVDRARRGLHHLAERRVDAYPNLLQEKPDQ
>NZ_CP049748.1|WP_037151734.1|905174_906446_+|MSMEG_0569-family-flavin-dependent-oxidoreductase
MTTNGGTEHHSVIVIGGGQAGLSISWHLTQRGIEHVVLERDTIAHEWKDSRWDNFTLVTPNWQCALPGYSYDGDDPDGFMQRDEVYAFVRRYAESFDAPVREHVSVDQALQSADGGFDLQTSAGPMHADQIVVAVGGYHIPTIPRFAEKLPRDVVQIHSSEYRGSHQFPDGDVLVVGTGQSGAQIAEDLHLDGRRVHLVAGTAPRVARFYRGRDCVAWLHDMGVYDVSIEDQPGGVGKRENTNHYVTGRDGGRDIDLRAFATEGMQLYGRLLGVEDGVLQFAPTLEASLDAADRVAESIKDNIDAYIEREGISAPTEERYVPVWRPEAETTELDLATSDVTAVVWSVGFRTDYRWLKVGAFDGEGHPTHNRGVTSVSGLYFLGLPWQHTWGSGRFASVARDAAFLADQIGLEISAAQPQSQMV
>NZ_CP049748.1|WP_032402847.1|918252_919980_-|dihydroxy-acid-dehydratase
MTTPQNPSEKQSPDIDVKPRSRDVTDGLEKTAARGMLRAVGMGDDDWVKSQIGVASSWNEITPCNLSLERLAKEVKKGVHAAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVISAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAGSTLPGFATLSDGSEHQVTIIDAFEAVGACSRGLMSRADVDTIERAICPGEGACGGMYTANTMASAAEAMGMSLPGSASPPAPDRRRDGFAHASGEAVVDLLRRGIRTSDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAHEAQVELTLADFTRVGAKVPHLADVKPFGKHVMTDVDAIGGVPVVMKALLDAGLMHGDCMTVTGKTVAQNLAHIAPPDPDGKVLRALDKPIHPTGGITILEGSLAPGGAVVKSAGFDSDVFVGTARVFERERAAMDALENGTITAGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCVGHVAPEAVDGGPIAFVRDGDQIRLDVGKGTLDLLVDAAELESRAQGWAPLPPRYTRGVLAKYSKLVGSASNGAVLI
>NZ_CP049748.1|WP_037151725.1|920201_921203_+|hypothetical-protein
MNDQPDTAVVEMLVELACRAPSVHNSQPWRWTYSSRGLDLYTDSSRLLGVIDPTERQMVLSCGAALDHLEKAAAAFRWTTEIDLLPTPGAPDHLAHVRFVHDAHPRSHEFDLLAAINRRHSDRRAFGPVPSNRILTRYLRQAQYGTEMTVLSAESKQTLAKASTLSASVRKYDATYQAEIRWWAGHSFRSGGIPPEALTNRAEASRVQVGRQFPEPHRVARTVTTEPVEDESTVVLLGTASDERLDWLQCGRAMSAFLLAATADGLATCPLTHLTEQSGSRHLVESLAPRNSLAQLLIRVGTPMIGSPPPRTPRHAVASVLSAPARTPNRRQS
>NZ_CP049748.1|WP_037151722.1|921199_922081_+|universal-stress-protein
MILAAHQKIVVGVDGSPNSVSAALWAATIAERLGSPMHIAGAVQQPAFYLGESASVIPRDVWDEQRHTAERVVTDVAAAVLARHPNSAVTTSVEETSACAMMVELSRTARMLVVGNSGSGPIVSALFGSTTQEISNAAQCPVIVWREGAETVDAPILVGIDGSATSEVAVGQAFELASLFGVSLIAALAWNSLSQGAALSLPGSPDPMEIEREQRMLMSECLAGWAEKYPDVSVEHIVQQGNPAHLLVDLSKRAGLVVVGSHGRGVVARALFGSTSSNLTRHAHCPVMICRDR
>NZ_CP049748.1|WP_037151719.1|922077_922896_+|hypothetical-protein
MTNRTVPNSMHSGERRRILDSATAHRLARQATVARLIGHDHFGPTIDIVSIVWVGTRVYFYADGRSRLGRSVLDSAVVLEVDAEDGARTTDSTVVIHGIARAVVDVRLEVLEELLPRPHSDGPPMHRLVEVSPTSVSGVELARCPIADEKDRPGRRDTCPSGPVRVDSDSITVEITTEPRPRKFPVTTAAIDGVVRAVMIAEYGPASGVSPDGHLLRTAVLDRWPGARVLERRSAGERGADPRGYESFYVELEPSGCRTDIDLVEVSALFGR
>NZ_CP049748.1|WP_037151716.1|922945_923824_+|universal-stress-protein
MSNSTARTLPIVVGIDGSAEAEAAARWAATYADKVHATVRLVHAVPEGDWYGSAAFVDGGALERDLRIIGRKHLTRAACAMHDAAPEVSVDIVTVDGTIASYLSNADAELIVLGSRKSSALRDLTLGSNTLRVVTHAHCPVLLVRGGGESVDPARPIVVGVDGSEQSDRALSAALEFAHTVGAPVVAANYWGFAAQPGLGTGFEGIDWVSVRAHEKHWLDAHVEKMHEKYPEVTLTTVSTQSSPTRGLRAMSASASMLVVGSRGRGVLRGAILGSVSQNLVHHADCSVLIVR
>NZ_CP049748.1|WP_037151714.1|923825_925259_-|MFS-transporter
MTAEGIALSSARGRWIVATTVLGSALAMLDATVVNIALPAIGRDLGAGVTGLQWTLSGYTLALASLILLGGSLGDRLGRRRVFIWGTVWFAAASVLCGLAPNIEVLIAARLLQGVGAALLTPGSLALISASIKAEDRGAAIGLWSGLGGVASAIGPLLGGWLVDAVGWRAVFLINIPLAVVVVSVAAKHVPESRDPHASGRLDVPGAVTVAAALGLLTYGLIESHTVALVLGVVAVGVFVVIERRSHDPLVPPSLFASRVFLAANLVTFAVYAALGGVFFLLVLQLQFAVGYSPIAAGVSTLPITALMLVLSARAGRLAGRIGPRIPMTVGPLLSALGLLLMLRIGPGSSYVADILPAVVVFGLGLSALVAPLTAAVLGAVSTDRAGIASGVNNAVARTSQLLAVAALPALAGIAGSDYSAPEVFSAGFHTAMLLCAGLLLIGAVIAAVLIRGTGDTSNCPPHCDMASPPMAPRRSA
>NZ_CP049748.1|WP_032402859.1|925255_925858_-|hypothetical-protein
MASSNRSVRALVLALTACTALILAGCASEVSGTAVAISGATIAPTTTSAPRTTAAPTPEIDDGGSVDIDVEIGECVNLGGTVDEATIANATCGSPESNYVVFAKTPTSAECPADADQYYYETYFDIEQGALCLDIDWVVGGCMDIVGEFAQRVDCATPGADTRRVVTILQGTSSVDDCPDPALYGYEKDTRNFVVCVERL
>NZ_CP049748.1|WP_032402858.1|925962_927012_+|ATP-dependent-DNA-ligase
MDLPLAVPVAPMLAKAAKVVPAQPEDGPPVWSYEPKWDGFRAIVFRDGDEVVLGSRGGKDLARYFPELVEAVKAELPEKIVVDGEIVVPREKNGSTRLDWESLSERIHPAASRVTMLAEKTPAQFIGFDLLAVGNEDLTSEPFSTRRARLLDAVGTGGPSCFVTSATDDAAVAEDWFERFEGAGLDGVVAKKLDGLYLPNKREMVKIKHARTADCVLIGYRIHKSGNGIGSLLLGLYDGDDLRMIGGASAFTDKRRLELLEELEPLRLGEDVTYDGEATRWNSSNDRNWIPVRIERVIEVAYDQMEGARLRHVARFLRWRPDREPRSCAYDQLEVPVRYDVADVIAGGR
>NZ_CP049748.1|WP_037151712.1|927014_928100_+|DNA-polymerase-domain-containing-protein
MAAKTPPAFVQVGEREVRVSSPDRVIYEATESTPDITKLQVCEYFAAVGEPLMRAIGDRPTAMERWPDGYREGMRLALGPQDKEGDGFYQKRLPKGAPEWIETVKIAFPSKRTAEELCPSEPAALVWAAQMGTLTFHPWPVRRPEVDHPDELRLDLDPQPGTTFADALRVADVTRELLEELGLRGYPKTSGNRGIHIYVRIEPEYTFEQVRHAAIGLGRELERRDDGVTTNWWKEERGERIFIDYNQNNRDRTIASAWSLRARPGAPVSTPMTWSQLADVTDPREFNLVTVPELVQDGDPWADMDSQAYSLEPLLHLWETLPGGELNFPPDYPKMPGEPPRVQPSKKVAEHWDAEGNRTES
>NZ_CP049748.1|WP_037151709.1|928185_930042_-|Na+/H+-antiporter-NhaA
MADQITPTNRPMARFVERISRARGERNSETLAAGFLLAATLIALIWANSPLGETYQSFWHTELSVTVGEHGISLDLAHWVNDGLMALFFFVVGLEVKREFAMGELTDRSRAAIPIVAALAGLAAPALLFLAFNPSGPAAQAWGVVISTDTAFLLGALAVLGPKKAARLRIFLLTLAVADDVGALAIIAFFYTDDLDVVPLVLAFIGLGLIFLLRRLEVWRGVGYFVVALFTWVAMYESGVHPTLAGVMIALILPVYPPRRSEVERASDLTRAFRQSPNPEYARAARLGLDQAVSVNERLMRLYQPYTAFIIVPIFALANAGVVLSSDTLKAASTSTLTWGIIAGLVLGKLVGITGASAIFAKLRPSALAPGLTLSHIAGGAAMSGIGFTISLFIIDLALDDPLLADEARVGVLAASVIAALLGWILFRIDAKIHPPKAEASLRILRPVSAKRDHIRGPVDAPLTIVEYADFECPFCSKATGSVAEVRKHFGDDLRYVYRHLPLDDYHPHARYAAYASEAAAAQGKFWEMADVLFRNSDALEPDDIDGYARELGLDMDRFEDDIRTGDYVVRVEDDELDATSSDVGGTPTFYLGRGDKNLTRHVGPYDAATLIRELESM

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Crispr_ID: NZ_CP049748_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049748_4

3413993-3414066

Orphan

Consensus_repeat	Method
CCGGGTGCGCCGCCTTGGGGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049748_4

>merge|NZ_CP049748|4|3413993-3414066|CRISPRCasFinder
CCGGGTGCGCCGCCTTGGGGTGGATAGTTTCCGGGCGGTGGGGGATATCCACCGGGTGCGCCGCCCTGGGGTGG

>NZ_CP049748|4|4|3413993-3414066|CRISPRCasFinder
CCGGGTGCGCCGCCTTGGGGTGG	ATAGTTTCCGGGCGGTGGGGGATATCCA
CCGGGTGCGCCGCCCTGGGGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049748.1\|WP_032403343.1\|3420689_3421589_+\|transglutaminase-family-protein	unknown	unknown	gnl\|CDD\|224224
NZ_CP049748.1\|WP_155292655.1\|3411730_3412909_-\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_CP049748.1\|WP_037150545.1\|3421744_3422914_+\|kinase	unknown	unknown	gnl\|CDD\|223584
NZ_CP049748.1\|WP_037153202.1\|3407132_3407603_-\|DUF3237-family-protein	unknown	unknown	gnl\|CDD\|179149
NZ_CP049748.1\|WP_032377794.1\|3427088_3427649_+\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|234639
NZ_CP049748.1\|WP_037153196.1\|3405221_3406493_+\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234586
NZ_CP049748.1\|WP_037153193.1\|3404526_3405219_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NZ_CP049748.1\|WP_032377781.1\|3403471_3404335_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|238194
NZ_CP049748.1\|WP_037153199.1\|3406482_3407121_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_037150548.1\|3417996_3420690_+\|circularly-permuted-type-2-ATP-grasp-protein	unknown	unknown	gnl\|CDD\|379601
NZ_CP049748.1\|WP_037150536.1\|3429083_3429896_+\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|234703
NZ_CP049748.1\|WP_032403345.1\|3422987_3424370_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NZ_CP049748.1\|WP_037153209.1\|3409853_3411659_+\|aspartate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234775
NZ_CP049748.1\|WP_037153206.1\|3408768_3409683_-\|membrane-protein	unknown	unknown	gnl\|CDD\|225203
NZ_CP049748.1\|WP_032403341.1\|3414481_3417871_+\|transglutaminase-family-protein	unknown	unknown	gnl\|CDD\|378297
NZ_CP049748.1\|WP_080734377.1\|3430018_3430591_+\|prepilin-peptidase	unknown	unknown	gnl\|CDD\|224900
NZ_CP049748.1\|WP_037150542.1\|3424413_3427083_+\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NZ_CP049748.1\|WP_037153205.1\|3407730_3408759_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275263
NZ_CP049748.1\|WP_052058630.1\|3402674_3403475_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223725
NZ_CP049748.1\|WP_037150539.1\|3427645_3429082_+\|aminodeoxychorismate-lyase	unknown	unknown	gnl\|CDD\|224475

Protein	Function_ID	Function_description	E-value
NZ_CP049748.1\|WP_032403343.1\|3420689_3421589_+\|transglutaminase-family-protein	gnl\|CDD\|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	1.32661e-51
NZ_CP049748.1\|WP_155292655.1\|3411730_3412909_-\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	2.14418e-102
NZ_CP049748.1\|WP_037150545.1\|3421744_3422914_+\|kinase	gnl\|CDD\|223584	COG0510, ycfN, Thiamine kinase and related kinases [Coenzyme transport and metabolism].	0.000116113
NZ_CP049748.1\|WP_037153202.1\|3407132_3407603_-\|DUF3237-family-protein	gnl\|CDD\|179149	PRK00872, PRK00872, hypothetical protein; Provisional.	3.47744e-26
NZ_CP049748.1\|WP_032377794.1\|3427088_3427649_+\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|234639	PRK00109, PRK00109, Holliday junction resolvase RuvX.	2.46177e-54
NZ_CP049748.1\|WP_037153196.1\|3405221_3406493_+\|histidine--tRNA-ligase	gnl\|CDD\|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	0
NZ_CP049748.1\|WP_037153193.1\|3404526_3405219_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	3.56834e-70
NZ_CP049748.1\|WP_032377781.1\|3403471_3404335_-\|peptidylprolyl-isomerase	gnl\|CDD\|238194	cd00317, cyclophilin, cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug cyclosporin (CsA). Immunosuppression in vertebrates is believed to be the result of the cyclophilin A-cyclosporin protein drug complex binding to and inhibiting the protein-phosphatase calcineurin. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. Cyclophilins are a diverse family in terms of function and have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. This group contains human cyclophilin 40, a co-chaperone of the hsp90 chaperone system; human cyclophilin A, a chaperone in the HIV-1 infectious process and; human cyclophilin H, a component of the U4/U6 snRNP, whose isomerization or chaperoning activities may play a role in RNA splicing. .	1.43412e-45
NZ_CP049748.1\|WP_037150548.1\|3417996_3420690_+\|circularly-permuted-type-2-ATP-grasp-protein	gnl\|CDD\|379601	pfam14403, CP_ATPgrasp_2, Circularly permuted ATP-grasp type 2. Circularly permuted ATP-grasp prototyped by Roseiflexus RoseRS_2616 that is associated in gene neighborhoods with a GCS2-like COOH-NH2 ligase, alpha/beta hydrolase fold peptidase, GAT-II -like amidohydrolase, and M20 peptidase. Members of this family are predicted to be involved in the biosynthesis of small peptides.	2.09472e-165
NZ_CP049748.1\|WP_037150536.1\|3429083_3429896_+\|shikimate-dehydrogenase	gnl\|CDD\|234703	PRK00258, aroE, shikimate 5-dehydrogenase; Reviewed.	2.15323e-89
NZ_CP049748.1\|WP_032403345.1\|3422987_3424370_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NZ_CP049748.1\|WP_037153209.1\|3409853_3411659_+\|aspartate--tRNA-ligase	gnl\|CDD\|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP049748.1\|WP_037153206.1\|3408768_3409683_-\|membrane-protein	gnl\|CDD\|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	2.91334e-99
NZ_CP049748.1\|WP_032403341.1\|3414481_3417871_+\|transglutaminase-family-protein	gnl\|CDD\|378297	pfam09899, DUF2126, Putative amidoligase enzyme (DUF2126). Members of this family of bacterial domains are predominantly found in transglutaminase and transglutaminase-like proteins. Their exact function is, as yet, unknown, but they are likely to act as amidoligase enzymes Protein in this family are found in conserved gene neighborhoods encoding a glutamine amidotransferase-like thiol peptidase (in proteobacteria) or an Aig2 family cyclotransferase protein (in firmicutes).	0
NZ_CP049748.1\|WP_080734377.1\|3430018_3430591_+\|prepilin-peptidase	gnl\|CDD\|224900	COG1989, PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	1.37875e-06
NZ_CP049748.1\|WP_037150542.1\|3424413_3427083_+\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NZ_CP049748.1\|WP_037153205.1\|3407730_3408759_+\|radical-SAM-protein	gnl\|CDD\|275263	TIGR04470, hypothetical_protein_ALIPUT_00462, radical SAM mobile pair protein B. Members of this family are the downstream member (B) of a pair of tandem-encoded radical SAM enzymes. Most of these radical SAM gene pairs have an additional upstream regulatory gene in the MarR family. Examples of high sequence identity (over 96 percent) from cassettes in several Treponema species of the oral cavity to those in multiple Firmicutes in the gut microbiome suggest recent lateral gene transfer, as might be expected for antibiotic resistance genes. The function is unknown.	5.07761e-16
NZ_CP049748.1\|WP_052058630.1\|3402674_3403475_-\|peptidylprolyl-isomerase	gnl\|CDD\|223725	COG0652, PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones].	2.65014e-48
NZ_CP049748.1\|WP_037150539.1\|3427645_3429082_+\|aminodeoxychorismate-lyase	gnl\|CDD\|224475	COG1559, COG1559, Aminodeoxychorismate lyase [Coenzyme transport and metabolism].	1.66501e-81

>NZ_CP049748.1|WP_155292655.1|3411730_3412909_-|IS30-family-transposase
MSRREAAREVGVHLRTAQDWDGGIRKIGGARLHPDGRRIDYKTGMTTFVTAAQRPSLARIESTLHPRYLTVTDREHIADLRRAGCSLREIGRRLGRAASTVKREIDTYGIANEYHPHRAHRLWAISRARPKPAKLAAQGSLRSYVAGKLALQWSPEQICHALVVDFPDDKAMRVSTETIYQAIYVQSRGGLRREVAAALRTGRTRRVQHRSPEQRTSRFVDAMVMISERPADVADRSVPGHWEGDLIVGTRSESAIVTLVERSTRYLLLGHLPGGHTAEEVRDVLVPLIGSLPTHLRGSLTWDQGCEMAAHKQFSVATGVPVYFCDPHSPWQRGSNENTNGLLRQYFPKGTDLSVYSATDLENVAHRLNSRPRKTLGWKTPAERLRDLLTGI
>NZ_CP049748.1|WP_037153209.1|3409853_3411659_+|aspartate--tRNA-ligase
MLRTHLAGSLRPEHVDRTVTLTGWVARRRDHGGVIFIDLRDASGVSQVVFREGAALEQAHRLRAEYVVKVTGKVEGRPEGNANYEIPTGAIEVEASEIEVLSEAAPLPFQLDDQPGEEARLKYRYLDLRREGPGRAIRLRSHVNAAARSVLAHHEFVEVETPTLTRSTPEGARDFLVPARLQPGSFYALPQSPQLFKQLLMVGGIERYYQIARCYRDEDFRADRQPEFTQLDVEMSFVTQDDVILLAEEILASLWKLVGHHFTAPIPRITYAEAMRRYGSDKPDLRFDIELVECTDFFSETTFRVFQAPYVGAVVMPGGASQPRKQLDRWQEFAKQRGHKGLAYVLVGEDGTLGGPVAKNLTDAERDGLAAHVGANNGDAIFFSAGPVKASRGLLGAVRGEIARKLDLIDPKAWAFVWVVDAPLFEPTSDATASGDVAVGSGAWTAVHHAFTSPKPESMETFDTDPGSALAYAYDIVCNGNEIGGGSIRIHRKDIQERVFAIMGIGKEEAQEKFGFLLDAFSYGAPPHGGIAFGWDRITALLAGVDSIREVIAFPKSGGGIDPLTDAPAPITPQQRKESGVDFKPEKKEESPASAETVVDA
>NZ_CP049748.1|WP_037153206.1|3408768_3409683_-|membrane-protein
MTFREGSQSEPGRVSVGGGGGGGRGKLAIGGGAGGLVVIVLALLFGGDPGAILNQISGGDSSAGQNDSGSSGTLDCDVTEANSNVDCRVDFTVASLDTVWESQLQSQTGVAYVQPAVNLFSGATNTGCGNATSAVGPFYCPADSTAYFDTSFFQVLVDQFGSSGGPLAQEYVVAHEIGHHIQNQLGDIGRAQADPQGPESGGVKVELQADCYAGIWAHYAAETVDPKTGVPFLEPLTTTDINDALSAASSVGDDRIQQASTGRVNPEGWTHGSSAQRQAWFTAGYETGQVAACDTFSARDLNNP
>NZ_CP049748.1|WP_037153205.1|3407730_3408759_+|radical-SAM-protein
MRWAGQTLEAADDGALPGLERSGLVRSVQTPEFEGITFHEVLCKSALNEVPGESQVPFSWTVNPMRGCSHACRYCFARPTHEYLDLDSGNDFDSQIVVKTNVAAVLRKELARRSWKREPVALGTNTDPYQRAEGRYRLMPGIIRVLTESGTPFSILTKGTLLRRDLPLLTLAAQQVDVHVSISLAIHDPDLQKQLEPGTPSPRARLDLIRAVRDAGLDCGVLVAPVIPFLTDGAKHLDGLISALADAGATSVTALPMHLRSSTKDWYMSWLVKEHPALVRRYRQLYGHGAYVTPEYKQWLRGRIDPLLETYGFAVEQTRSLPANEPAEPREPATSGPALTLF
>NZ_CP049748.1|WP_037153202.1|3407132_3407603_-|DUF3237-family-protein
MTAPNTPTLEPILRLGLTLGPAIEIGPVPEGDRVVTTVLGGAAPGPDIEGTLAARSTVVSVTRPDGCTEFSSDLVLELATGGYLSLNYRGVQFGPAEVIDALDDPDREVDPATYYFRGTLRVSTAVPKFTYLNRALVVTSGSRSAEAVVLDAFLVT
>NZ_CP049748.1|WP_037153199.1|3406482_3407121_+|hypothetical-protein
MADNPRPASGPVALDLVSVEFLAPRLRKIIVGSAAIGIVLAVVLALFVPVWVAVLVGVVIGGPAVLSGWLGLRRRVWLDGPQLCARGLRTRRLRMPEVVTAELTIRTAGIDQISLRLYDGRTRVVLPLALYTSGGGRELPILALRTLADSLWTTELVPAAAVASVLVDQLRAEARDAGLDERPLYRAIELVRSKGRTPHATLTDREVAQLLR
>NZ_CP049748.1|WP_037153196.1|3405221_3406493_+|histidine--tRNA-ligase
MSKPTTFSAPKGIPDYFPPNSAEFVAVREGLLDAARNAGYGHIELPIFEDTGLFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVMRAVIEHGLDRGALPVKLAYAGPFFRYERPQAGRYRQLQQVGVEAIGIDDPALDAEVIAVADAGFRALGLTGFRLEITSLGDDTCRPQYRELLQQFLFALPLGEDTRRRAEINPLRVLDDKRPEVREMTADAPLMLDHLSDSAKEHFDEVLAYLDVMNVPYLVNPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMEQLGGQALSGIGFGLGVDRTVLALAAEGKTAGATSRCQVFGIPMGAAAKLAIVDIAAQLRERGIAVDMAYGNRGIKGAMKAADRSGARYALVLGDQELSAESVVVKDLSNGEQDTVALADVVDALGVHLGR
>NZ_CP049748.1|WP_037153193.1|3404526_3405219_+|MBL-fold-metallo-hydrolase
MLVTGFPAGMFQTNCYILAQDDASECVVVDPGQDAADPLIDFLTRSSLTPTAVLLTHGHLDHTWSVEPICEKYGIAAYIAPEDRYMLSDPIKGTGPALAAVLGDIEFREPAEVIELADGKQLDLAGIEFSVVHTPGHTQGSVVFLARADGPDGAVPLALTGDTLFAGSIGRTDLPGGDHEQLLRSIATRLLPLGDDTVVLPGHGGQSSIGQERASNPFLVGLGDPEQGKL
>NZ_CP049748.1|WP_032377781.1|3403471_3404335_-|peptidylprolyl-isomerase
MPSNEQRREAAKRKLERQLVRRAERARRRKQLTIAGSILGVVAVVAVVSVVYVVTRGDDDASTAQESTTSAPADSLIAAGRSEPLPETVNCSYPAAAQPAAKENTPPRTDNVPTSDEPLSYSMTTNQGNIGLTLNNPESPCTVNSFVSLANQGYFDGTTCHRLTTGAGLQVLQCGDPTGTGSGGPGYQFADEFPTDTFAEGDPAAQTPIAYPRGTLAMANAGPGTNGSQFFLVYGDSELPPAYTAFGTIDETGLATLDAIAAKGVQGGASDGAPAEPVDITNMLSDL
>NZ_CP049748.1|WP_052058630.1|3402674_3403475_-|peptidylprolyl-isomerase
MNRTSVLLTGLSATALVLAGCSSSAEPAAQPAAATSSTTSSAPAATTTQRPALDLSRFGALPAVPQPTTDTVSCAYPAETPAAKEVDPPPVDNVDVYGTVDVALATSQGPIDITLDRTQAPCTVNSVVSLVQQGYFDGSPCHRLTTSPGLEVLQCGDPSGSGRGGPGYSFANEYPTTTYTGDPAQAENPVVYPRGTLAMANAGPDTNGSQFFLVYADSVLPPQYTVFGTISESGLATLDAIAAGGVTGGSEDGAPANPVILESATA
>NZ_CP049748.1|WP_032403341.1|3414481_3417871_+|transglutaminase-family-protein
MGIKVALEHRTSYQFDRTVKIFPHEIRLRPAPHSRTPIEAYSLKIEPAEHFVNWQQDVFGNFLARVVFPERTDHLSITVGLVADMASINPLDFFVEEWAEHFGFAYEEHDLPDLEPYLRPVDEDKAGSGPGPVVSAWVEKLQAAVVERGESLRTIDFLVMANQAVMGDVGYSVRMEPGVQTPDLTLTSAVGSCRDSAWLLVSVLRQMGLAARFVSGYLVQLSSDVKSLDGPSGPVEDFTDLHAWTEVYLPGAGWVGMDPTSGLFAGEGHIPLSATPHPSTAAAISGATSKCKAELDFSNTVVRVHEDPRTTLPYTADQWESIKVTAAKIDKRMHDQDIRLTVGGEPTFVAIENQEAPEWNTTADGPHKRKLASVLAERLRTIYAPDGLVQRSQGKWYPGEPLPRWQVGLFWRTDGQALWHDSDLIADPWLAEDLRPEPVDNSASQELIDELVKALGLPASQARPAYEDPLVKLLDLVRQPYGDPPADDDDLEPGADSANARKQLLERLDASTDEPAAFVLPISRTEDGSGWESSDWKLRRGRIVLLEGDSPAGLRLPLRAISWDGGPVENPSDPTAPTPDLPIRQLTQQPPRAVNPAESRYAQLVNETSGVGGTAVTALVAEVRDGVLHVFMPPMDRLDDFVDLVSRVEHAASTIDTPVVIEGYGPPSDPRIQTLTVTPDPGVIEVNVQPTSSWAEQNELMERLYLEARKSRLSTEGFDNDGTTRGTGGGNHITLGGVTPVDSPVLRRPDLLVSLLTHWQRHPSLSYLFSGRFIGTTSQAPRADEGREESLYELEVAFSEIRRLTDGDRSASPWVVDRALRHLLTDITGNTHRAEFCIDKLYSPDSTRGRLGLLELRGFEMPPHHQMAMVQSLLVRSMVSRFWDTPLQAPLIRHGANLHGRYMLPHFVINDIGRVVEDLREHGIEFDTSWLDPFTEFRFPRIGTTVVGDAEIELRGAIEPWNTLGEESTSSGTARYVDSSVERIQVQVAGADAGRYLLTCNGVPVPLLRTDRQDVQVAGVRYRAWQPPSALHPTIEVQSPLRFDLVEMQTGRAVGGCSYHVVHPGGRSYDGPPVNSVEAEARRNGRFEEGGFTSGKVDVARLLEMHARQAIDVSAPGMLDLRRTGVHTP
>NZ_CP049748.1|WP_037150548.1|3417996_3420690_+|circularly-permuted-type-2-ATP-grasp-protein
MVPVDTALSGAGRNEPVTGGAGRSEEVSSGAGSAWLAYRGRREAVIGRADRFDEMLDPDDNIRPHWAGLIDGMREAGSGAMQTLQSRVSRLVDDHGITYNPIPSGGSEAVPSAVRWGLDSVPLVVAADEWDRLEAGLVQRSMLLDAVLADIYGAQETVRRGLIPPELIFGNPGYLRAAHAITIPGPHQLFMHAADVARGSDGRFQVVADRTQAPSGVGYALADRRVMSRAMPELFQESNPRPLSTFARAVRLALRDAAPASAEDPVVVVLSPGSHSETAFDQAYLATVLGFPLVENADLVVRDGCLWMRSLGKLRRVDVVLRRVDAEFADPLDLRPDSHLGVVGLVEALRRGAVSVVNTLGSGVLENSALVPLLPALSRALLDEDLVLDSVATYWGGDPDQLSHIGNRLRSLVLRSTTSRRTVVGHDLTDAGARDLWDRIVAEPWKWTGQEVPEFSVAPVGSSIGGGAGEQLAVAPAQVGMRLFTVAQRGGYTPMRGGLGQVVITAPVTDPLITVASKDVWVKSLERVTPADSAPHTPPATVEELPQYAASNVDVVSSPRVLGDLFWFGRYTERAEDMTRLLIAARERNQDYRSMPWLEGSESLPILLEAVTKVSRTGPGFLDEKTRADAIVELRSLMLSAARLGSLAQSVDRMQQAARAVRDQLSNDTWAVLNRIDTALEELAESPVNNGAQLAASQSSVLRGLLAVSGLASESMVRDAGWYLMDAGKRIERGLQLTALLSATLSHALTPSTEQAVIDSVLSAAESSVIYRRRNSGRARPAAVAQLLLFDEGNPRALVYQLDRLRDDLGSLPDASGTSRPEQLVEQMRVRLRRVDPGDLESVDANGRRVDLIELVDGIHDSLEELSRVVLATHMSLPGGTQPLWGSSNIRTANGVQ
>NZ_CP049748.1|WP_032403343.1|3420689_3421589_+|transglutaminase-family-protein
MSRRYRIKHITTYTYSDRVSSSYGRGFLAPRDMDGQHCTEKSVTVEPAPTDQSFGVDVYGNEDVYFHVTHDHEKLVVTADSLVEVYPRPVDETTSWPATAPWESARMTLFDPTVPADSARASAVEFALDLPTPEITDEVRAYAAPSFRPGRPLADVIVDLTHRIFTDFRYLSGSTTVSTTVVDVLSARSGVCQDFARLAIACLRSQGLAARYVSGYLATEPPPGKERMIGVDATHAWAAVWMPNDRWLAFDPTNDQLVDERYATVAWGRDYADVPPLRGVIYTEAEESTISVSVDVAPQ
>NZ_CP049748.1|WP_037150545.1|3421744_3422914_+|kinase
MTATLADPVSEVVAAAQRLLAKRTGAPVTLIDPVNLGGSGQAIVLRVKVSENPFQLPRTLVLKQVRDVAGESELHTELADIAGSSAFLREAASYQFANALATDSRPGPELHAYDLDARLLVLSDLGDASPITTLLRNSDEAAVTNSLMAMAQALGRMHAATVGREDDFAALLRRVGQPDTTDGISAQIPDALTEVPELLAGLPGVGPTPDSLLDRVSRSGRLFAHGTFRAFSPSDLCPDNIIVNDEGVRFLDYEWGGFRDATLDITYALASFPGCLCSFELTHEREQAMIDAWRSEVVGIWPALADDTALASKILDARLIWVWLTTYWFLPDDHTRIAAARAHHLSVPRSQALVSRWAVLADSAERAGETGIAEYAASVATALRAKWER
>NZ_CP049748.1|WP_032403345.1|3422987_3424370_+|replication-associated-recombination-protein-A
MSGSDVSSSDDPGDGLFDTPAPPETTIEESRPTSTYVRPDAPLAVRMRPTTLDEVVGQSHLLAPGAPLRRLVEGSGASSVMLYGPPGTGKTTLASLISGATGRKFEALSALSAGVKEVRNVIELARRRLLSGEQTVLFIDEVHRFSKTQQDALLAAVENRIVLLVAATTENPSFSVVSPLLSRSLVLQLQPLGTEDIELLLTRAANDPRGLDGAVTIAEDAMDHLVRLAAGDARRALTALEAAAGAATDGTLDLATVEASVDKAAVRYDRDGDQHYDVISAFIKSIRGSDVDAALHYLARMITAGEDARFIARRLVVHASEDIGMADPTALQTATAAANAVQMIGMPEARLALAQATIHLATAPKSGAVIAALGAAMADVAAGKSGSVPPHLRDGHYKGAQGLGNAVGYRYPHSSPGGVLGQQYPPDELVGVNYYEPTEHGAEREIATRVGKLRRIIRGR
>NZ_CP049748.1|WP_037150542.1|3424413_3427083_+|alanine--tRNA-ligase
MQTHEIRRRFLDHFVKAGHTEVPSASLILDDPNLLFVNAGMVPFVPFFLGQQTPPYKTATSVQKCVRTLDIENVGITTRHNTFFQMAGNFSFGDYFKRDAIRHAWSLLTDSVEDGGYGFDPERIWATAYLDDDEAIELWKEIAGLPDERIQRRGMADNYWSMGIPGPCGPCSEIYYDRGPEFGAEGGPEADEDRYIEIWNLVFMQNERGKGISKDDFEILGPLPKQNIDTGMGVERVAFLLQGVDNVYETDLVRPVIAKAEELSGRAYGANHDDDVRFRVIADHARTAALLISDGVNPGNDGRGYVLRRLLRRIVRSARLLGAPDETMAQFVTVVRDTMAESYPNLVTDFDRILTVAVGEETAFLKTLTSGSRLFEGAAEAVKASGAKKIGGAEAFALHDTYGFPIDLTLEMAAEAGLSVDEDGFRSLMAEQRNRAKDDARARKHAHADLTVYKDFVDGSPTEFTGFDELGSEATVLALISNGVRVPTAVAGESIEVILDRSPLYAESGGQIADIGTITAPGLEVKVNDVQKIAKKVWTHKSVVESGQITEGDTVHVDVDHAWRKGATQGHSGTHMVHAALRQVLGPNATQAGSLNKPGYLRFDFSWQGALSEAQRDDIENVANDAVGSDFAVNTLVTDLDSAKKMGAMALFGENYGDEVRVVEIGGPFSMELCGGTHVQHSSQIGPVTILGESSVGSGVRRVEAFVGLDSYRYLAKERALLAGIASSLKVPSEEVPARIETLVERLRVAEKELDAVKAAAVLASAGEFVGKAERFGDVRAVVAQAPDGVGGNDLRTLVTDIRGRLGADAAVVVLFGTVGGKVPFVVSTNKAAQDAGVAAGDLVAAFGPSIGGRGGGKPELAQGSGSDVAGIAAGIDAARARLSELTSR
>NZ_CP049748.1|WP_032377794.1|3427088_3427649_+|Holliday-junction-resolvase-RuvX
MANLGRGPDRPGVDDPGRGRRIGIDVGSVRIGIASSDPDGVLATPVETVPRSKIKGPDAPDVVRVAEIVAEYEAVEIVIGLPRTLRGERGSAVDAAERFGRSLHRRLGDVPIRMADERLTTVSASRALRDSGVRAKNQRSVIDQAAAVAILQGWLDERRAVSTRGAADRAVSDHAGTNSGSTEVDE
>NZ_CP049748.1|WP_037150539.1|3427645_3429082_+|aminodeoxychorismate-lyase
MNNHGSFDRDRRHARSDEAHTDPIGYRVDEGSDFDRRMNGRPRPPQRHEPHPTPAPGADRERDRTARSDSERGAEPREVGRSRAASRRDRAASTRKRRGRIVALALGLVLIVAVAGGGYFAVSKFGNRTTPNADFAAGSSGDGVVIQVHPNDTAQQIGTEAADKGVVASSGAFLEAAIANNAITSVQPGFYLLTSNVPASRAVSELVDPASRVGNMVISEGRQLHDARDVNTGAVKKGIYTLISEASCVDRTGSGTPACVSYDDLNAAGAVDDPAALGVPAWATDRVEGVPDRDRQLEGLIAAGTWDFDPSAAPADILKQLVSESATRYEDTGILTAGTNSGLTPYDTLVAASLVERESLPQDFSKVARVILNRLAVPQKLEFDSTVNYSLDTTEVATTDADRARVTPWNTYASEGLPATPISSPSIGAVQAVEAPADGDWLYFVTINQAGETLFTRSYEEHLANIAKVEPGFLDSGR
>NZ_CP049748.1|WP_037150536.1|3429083_3429896_+|shikimate-dehydrogenase
MRAAVLGSPVEHSKSPLLHRAAYRALGLDGWTYDRIECTGEQLPGKLDGFGPEWVGVSVTMPGKVAALNYAGERTERAVLAGSANTLVRTASGWRADCTDVDGIVGALRGAGVVDLSGSSVTVVGAGGTSRPAIVALAGLGAAAVTVVARSADRASDTLRCAVSAGLRAEFADMTDPRLAAIASASAVLVSTVPAAGAAHIATALAHARLVLDAIYDPWPTPLAAAVEQAGGTVVGGLAMLLEQAYGQVEQFTGEPAPRAVMRAALATAE
>NZ_CP049748.1|WP_080734377.1|3430018_3430591_+|prepilin-peptidase
MFGLCAASVIGAVAGVAMRFGLVRWDPRFLPLLSAVGTGWVWWRFGETTYWVPLCVLTWWFVALSAIDLRRRRLPNELTIPGAIVVTTMLVSVGSARALLGGVLLFAIYLVVHLLAPSAFGAGDVKLAWSVGSIAALGGGEGWVIAALSAPLATAVVGSIVAAVGHSRARIPHGPSMCAATLLASAACLT

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Crispr_ID: NZ_CP049748_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049748_5

3865829-3866172

Orphan

Consensus_repeat	Method
CAGAAGCGCGGGTCCAAGCTCGCCGA	CRISPRCasFinder

5 spacers

The CRISPR arrays of NZ_CP049748_5

>merge|NZ_CP049748|5|3865829-3866172|CRISPRCasFinder
CAGAAGCGCGGGTCCAAGCTCGCCGAACTCGCCGCCGACCGCGGCAGCGACCTGGCCGACGAGGCCCAGAAGCGCGGGTCCAAGCTCGCCGACAAGGCAGCGCACCGCGGAACCGACCTGGCCGAACTCGCGCAGAAGCGTGGATCGAAGCTCGTCGACGTTGCCGCGGATCGTCGCGTCGAACTGGCCGACGTCGCGCAGAAGCGGGCATCCAAGCTCGCCGATCTGGCCGCTGAGAAGGGCTCCGTCCTCGCCGACGAGGCTCAGAAGCGCGGAGTCACGTGGGCCGATCTGGCGTCCGATCGCGTGGAGACACTCGGCAAGCGCGCTCGCAAGCGCGCCGA

>NZ_CP049748|5|5|3865829-3866172|CRISPRCasFinder
CAGAAGCGCGGGTCCAAGCTCGCCGA	ACTCGCCGCCGACCGCGGCAGCGACCTGGCCGACGAGGCC
CAGAAGCGCGGGTCCAAGCTCGCCGA	CAAGGCAGCGCACCGCGGAACCGACCTGGCCGAACTCGCG
CAGAAGCGTGGATCGAAGCTCGTCGA	CGTTGCCGCGGATCGTCGCGTCGAACTGGCCGACGTCGCG
CAGAAGCGGGCATCCAAGCTCGCCGA	TCTGGCCGCTGAGAAGGGCTCCGTCCTCGCCGACGAGGCT
CAGAAGCGCGGAGTCACGTGGGCCGA	TCTGGCGTCCGATCGCGTGGAGACACTC
GGCAAGCGCGCTCGCAAGCGCGCCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049748.1\|WP_037150749.1\|3864273_3864963_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NZ_CP049748.1\|WP_032404014.1\|3872321_3873179_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|372253
NZ_CP049748.1\|WP_037150753.1\|3869463_3872325_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224054
NZ_CP049748.1\|WP_032404019.1\|3856726_3857794_-\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780
NZ_CP049748.1\|WP_032404077.1\|3860616_3861003_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368530
NZ_CP049748.1\|WP_032378966.1\|3874116_3876279_-\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NZ_CP049748.1\|WP_037151175.1\|3861082_3864013_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP049748.1\|WP_037150744.1\|3854184_3856671_-\|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234804
NZ_CP049748.1\|WP_037150747.1\|3857867_3858674_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NZ_CP049748.1\|WP_037150755.1\|3876357_3876903_+\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|225188
NZ_CP049748.1\|WP_027497255.1\|3878638_3880117_-\|30S-ribosomal-protein-S1	unknown	unknown	gnl\|CDD\|236126
NZ_CP049748.1\|WP_032378969.1\|3878266_3878476_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_032378962.1\|3868828_3869281_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP049748.1\|WP_037150742.1\|3853563_3854115_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224755
NZ_CP049748.1\|WP_037150751.1\|3866435_3868757_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226482
NZ_CP049748.1\|WP_037150754.1\|3873185_3874052_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_008715923.1\|3859188_3859383_-\|50S-ribosomal-protein-L35	unknown	unknown	gnl\|CDD\|234676
NZ_CP049748.1\|WP_032378959.1\|3858712_3859102_-\|50S-ribosomal-protein-L20	unknown	unknown	gnl\|CDD\|179959
NZ_CP049748.1\|WP_032379505.1\|3859499_3860216_-\|translation-initiation-factor-IF-3	unknown	unknown	gnl\|CDD\|234582
NZ_CP049748.1\|WP_037150758.1\|3876919_3878137_-\|dephospho-CoA-kinase	unknown	unknown	gnl\|CDD\|179560

Protein	Function_ID	Function_description	E-value
NZ_CP049748.1\|WP_037150749.1\|3864273_3864963_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	3.24468e-40
NZ_CP049748.1\|WP_032404014.1\|3872321_3873179_+\|ABC-transporter-permease-subunit	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	1.48944e-05
NZ_CP049748.1\|WP_037150753.1\|3869463_3872325_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.97292e-83
NZ_CP049748.1\|WP_032404019.1\|3856726_3857794_-\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NZ_CP049748.1\|WP_032404077.1\|3860616_3861003_+\|hypothetical-protein	gnl\|CDD\|368530	pfam05626, DUF790, Protein of unknown function (DUF790). This family consists of several hypothetical archaeal proteins of unknown function.	0.00903052
NZ_CP049748.1\|WP_032378966.1\|3874116_3876279_-\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP049748.1\|WP_037151175.1\|3861082_3864013_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP049748.1\|WP_037150744.1\|3854184_3856671_-\|phenylalanine--tRNA-ligase-subunit-beta	gnl\|CDD\|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	0
NZ_CP049748.1\|WP_037150747.1\|3857867_3858674_-\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	1.52629e-65
NZ_CP049748.1\|WP_037150755.1\|3876357_3876903_+\|DUF402-domain-containing-protein	gnl\|CDD\|225188	COG2306, COG2306, Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only].	1.60982e-34
NZ_CP049748.1\|WP_027497255.1\|3878638_3880117_-\|30S-ribosomal-protein-S1	gnl\|CDD\|236126	PRK07899, rpsA, 30S ribosomal protein S1; Reviewed.	0
NZ_CP049748.1\|WP_032378962.1\|3868828_3869281_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	2.41666e-25
NZ_CP049748.1\|WP_037150742.1\|3853563_3854115_-\|hypothetical-protein	gnl\|CDD\|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	0.00994872
NZ_CP049748.1\|WP_037150751.1\|3866435_3868757_+\|AAA-family-ATPase	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	1.1262e-116
NZ_CP049748.1\|WP_008715923.1\|3859188_3859383_-\|50S-ribosomal-protein-L35	gnl\|CDD\|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	2.50481e-22
NZ_CP049748.1\|WP_032378959.1\|3858712_3859102_-\|50S-ribosomal-protein-L20	gnl\|CDD\|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	5.4955e-58
NZ_CP049748.1\|WP_032379505.1\|3859499_3860216_-\|translation-initiation-factor-IF-3	gnl\|CDD\|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	2.5176e-97
NZ_CP049748.1\|WP_037150758.1\|3876919_3878137_-\|dephospho-CoA-kinase	gnl\|CDD\|179560	PRK03333, coaE, dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional.	0

>NZ_CP049748.1|WP_037150749.1|3864273_3864963_+|MBL-fold-metallo-hydrolase
MDEHLMVIDDNYTGVVSQGSQPQRRTIPGATITKMSVGPMDNNTYLVVCSATGHSVLIDAANEAERISLLIDENAPTLSLIVTTHQHADHWQALADIAGGTDSPTAAHALDAEPLPVAPDRLLADRDMVTVGELTFDVVHLTGHTPGSIALALTDTDGTRTHLFTGDSLFPGGVGKTGSPEDFTHLLDDVTAKLFDRFGDDTVVYPGHGKDTTLGAERPHLAEWRERGW
>NZ_CP049748.1|WP_037151175.1|3861082_3864013_-|excinuclease-ABC-subunit-UvrA
MADRLIVRGAREHNLRGVDIDLPRDALIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTITEVYDYLRLLYARAGTAHCPVCGEQIAKQTPQQIVDQVLDMEEGLKFQVLAPVVRTRKGEFVDLFDSLNTQGYSRVRVDGVVHQLTSPPVLKKQEKHDIEVVVDRLTVKSSSKQRLTDSVETALRLADGIVVLDFVDRDENAPDRERRFSEKLACPNGHPLSIDDLEPRSFSFNSPYGACPDCVGLGVRKEVDPELVVPDGDLSLADGAIAPWSMGQTSEYFGRLLSGLADAMGFDLNAPWNKLPAKVKRAVLEGSDHQVHVKYKNRYGRTRSYYAEFEGVMPFLHRRLEQTESEQMKERYDGYMRDVPCPTCNGARLRPEILSVTIAAGDFGPKSIAEVCELSIADTANFLNSLTLGRREEAIAGQVLKEVQARLGFLLDVGLEYLSLARTAGSLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIDTLTRLRDLGNTLIVVEHDEDTIRTSDWIVDIGPLAGEHGGRVVHSGSYEDLLTNEESLTGAYLSGRMEIPLPDTRRVVDKKRLVTVVGAREHNLRGIDVSFPLGVLTSVTGVSGSGKSTLVNDILATVMANKLNGARQVPGRHTRINGLDQLDKLVRVDQSPIGRTPRSNAATYTGVFDKIRTLFAATTEAKVRGYQPGRFSFNVKGGRCEACSGDGTLKIEMNFLPDVYVPCEVCEGARYNRETLEVHYKGKTIAEVLDMPIEEAADFFEAITSIHRYLKTLVEVGLGYVRLGQPATTLSGGEAQRVKLAAELQKRSTGRTVYILDEPTTGLHFEDIRKLLGVVNGLVDKGNTVIVIEHNLDVIKVSDWVIDMGPEGGSGGGMVVAQGDPEAVAAVPESYTGKFLQEALTRESVVSQPVKAAPKKRRPRKVAAAR
>NZ_CP049748.1|WP_032404077.1|3860616_3861003_+|hypothetical-protein
MTSSPTPADGDPAGVDPVGTEPEVRELAEVPAVEVISRAAVMLMSSAAEKLGLSEPDPAESPYLDLDEARRVITALAGLVTASVEYLGPHAGPIRDGLQALQRAFREASAHPDEPGKGPGEKYTGPVH
>NZ_CP049748.1|WP_032379505.1|3859499_3860216_-|translation-initiation-factor-IF-3
MCQWQAVGLHTTPHYLGGPISTETRINDRIRVPEVRLVGPGGEQVGIVRVEDALRLALEADLDLVEVAPDARPPVCKIMDYGKFKYEAAQKARESRKNQTLTVIKEQKLRPKIDAHDYETKKRNVVRFLEAGSKVKVTIMFRGREQSRPELGFRLLQRLGADVAELGFVETSAKQDGRNMTMVLAPHKGAKTRVKAQESAAAPPAQRAPAPAPEQPADAAPAAEAPAAAAPATPAQTN
>NZ_CP049748.1|WP_008715923.1|3859188_3859383_-|50S-ribosomal-protein-L35
MPKQKTHSGAKKRFKVSGSGKILRQKAGRRHLLEHKPTKVTRRLDGVAVVKKADVPRIKRLLGI
>NZ_CP049748.1|WP_032378959.1|3858712_3859102_-|50S-ribosomal-protein-L20
MARVKRAVNAQKKRRSILEASKGYRGQRSRLYTKAKEQQLHSLTYAYRDRRARKGDFRKLWITRINAAARANDITYNRFVQGLKAAGVEVDRKILAELAVSDAAAFASLVAIAKAALPADVNAPAGEAA
>NZ_CP049748.1|WP_037150747.1|3857867_3858674_-|RNA-methyltransferase
MDSLTERTPRVVSAVKLARAAERKKTGQFLAEGFNAVSEAAKSGLVRELFFTSDAFDRHHALILSIEAGGARVFPITDRAAKALSDTVTPQGLVAVTGLVDVSLGRALADGPRLVAVPVEVAEPGNAGTVIRVADAAGADSVVLLGDSVDPHNGKCVRASAGSVFHLPIARERSIESGIEALRSAGLSIVATAADGEVDLDDADELLGRPTAWLFGNEAHGLPESVARDADHRIRIPIHGRAESLNLATAAAICLYASARAQRRSETS
>NZ_CP049748.1|WP_032404019.1|3856726_3857794_-|phenylalanine--tRNA-ligase-subunit-alpha
MAKKDVGPEPVDPSVLEESALGSAVDSAEQAFADATNLDALTKVKIDHVGGKAPLALAQRALGAIPGEQKADAGKRVKAARDRVQKAFDERRAILSAERDAAILVAETIDVTLPTGRAPVGARHPITIIAEQVADVFVGMGWEVEEGPEVETEHFNFDALNFLPDHPARTMQDTFHIAPEGSRQVLRTHTSPVQVRSMLSRELPIYVVCPGRTFRTDELDTTHTPVFHQVEGLAIDKGLTMAHLRGTLDAFAKALFGNDTRTRMRPNYFPFTEPSAEVDVWFPKKKGGAGWVEWGGCGMVNPKVLQASGIDPEVYTGFAFGMGLERTLQFRNDIPDMRDIVEGDIRFTLPFGVRA
>NZ_CP049748.1|WP_037150744.1|3854184_3856671_-|phenylalanine--tRNA-ligase-subunit-beta
MRVPQSWLTEVLHAGTPDWAVSPEELDAGFVRVGFEVEELESLDNVTGPLVVGRVSSIEELTEFKKPIRFCLVDVGADEPQEIVCGARNFAEGDLIVAALPGSVLPGGFAIASRKTYGRNSNGMICSTLELGLGRDHSGILVLPADTAAPGDDAKEVLGLKDSVIELNVTPDRGYAFSVRGLARELACSFDLPYVDPARTTPTEVTGEAWSVTVESNSGASRFALRKIVGIDPAATTPWWMQRRLLLAGVRPISVAVDVTNYVLHELGQPLHAFDAAKLNGDLVVRRANAGEKLTTLDGVERSLDPEDVVIADGSGAISLAGVMGGESTEVDDATTEVVLEAASFDPLAVFRTGRRHKLSSEASKRFERTVDSALPVAALDRAAQLLVEIAGGRIEPVLTDIGEAAEYPAVTMDFDLPDRIAGVQYPNGTAARRLTQIGCRVDVSVDDAGHGQLTVTPPSWRPDLVQRADLVEEVLRLEGLEKIPSVLPSAPGGRGLTAEQKRRRAVGKALAFSGYVEVLPPVFLPKGVFDTWGLDKDDPRRATTSVLNPLEADRPELATTVLPGLLEMLSRNIARGQRDVSLFGIAQVVLRHDATAAVDALPVDRRPTDDQIAMLRGSLPAQPVHVGVVLTGQRELSGPWGPGRAADAADAFAAVRTVAEAAGVHVDLRAAQHLPWHPGRCAEVLLDGEVVGYAGELHPAVLERAGLPPRTCAVELSLSALPVVESLPAPEVSPYPAVLQDVAVVVDASVPAASVEAALTIGGGDLLESIRLFDVYEGEQVGEGRKSLAFALRFRGTDGTLTEDQATAARDAAVDAAAKAVGAELRS
>NZ_CP049748.1|WP_037150742.1|3853563_3854115_-|hypothetical-protein
MSESGADGTASDLQVVHDVLAAVAGRQRLAPLAAAATALAAELGTVEPEPTGPDRGTPPGTVPDVDVPQVTRPRIDQPLGDPPPGAPLGGTVPGIIDAELVDDVPVGADGGYTGDAVGGFTESGVPTWDGVRDKVDHRSGTAVGAEELDRESRAGRDLDKQWNDRQEAGRKKLDEIRKSMGGS
>NZ_CP049748.1|WP_037150751.1|3866435_3868757_+|AAA-family-ATPase
MPDDGHTSSGSDIPIEEDLEQAHLTRLYTQLDALREYAANRLRAVLLETGGTPQARSERESFNQMYTEDIAKYDAAENGLCFGRIDLDPDSLDPKVDDRPERYIGRVGILDDKNDYETLLLDWRAPMARPFYLATPAAPENVLRRRHIRTRGRRVTSIADEFLDLNSARSSSDAAVAGGVASEGALLSALDAARTGQMNDIVETIQSEQDAIIRSQHRSVLVVQGGPGTGKTAVALHRAAYLLYTYRQQLGKSGVLIIGPNATFLDYIGQVLPSLGETGVLLSTIGDLYPGVRAQREDSALATEVKGRLSMVDVLTRAVRDRQEVPAQPRRLKFDTYDITLDRKIVTRARGRARSSRRPHNLARPLFVSSVIDQLANQLAAKLGQNLVDGSSLLSADDIADMRDEMREDQDVMAAVDELWPDLSPQQVLHDLFASPEKIASAAPELDAEERDSLSRRGRGFSAADAPLLDELAELLGVDDAAEREQAQRQWRGQIADAQGALDILTGSAPQDLEDELDPEILMAYDLIDADQLARRQNSGQRLTTAERAAGDRTWTYGHVIVDEAQELSTMAWRMVMRRIPNRWMTLVGDTAQTGDPAGTSSWSSVLEPYVAQRWKRTELTVNYRTPSEIMVVAHDVLAAIDPEQSEPRSIRSTGVTPWALQVLEADLFTAVEKRVAEHPRPGLSAVLVPAGRVSDLRHLASDVVTVSSVKDAKGLEFDSVLIVEPSAIVAESPKGMNDLYVALTRATQRLGVVHVDPLPKELSALQPFEPEA
>NZ_CP049748.1|WP_032378962.1|3868828_3869281_-|universal-stress-protein
MSAYRTVVVGTDGSESSLRAVEKAAALAGDADATLVIACAYYPADPKDTSAAADALREDAYQITGSAPTREILRTAREHATKAGAKNIEEKAIVGAPVESLLALVDEVKGDLLVVGNRGLNSLTGRLLGSVPSDAARKSTCDVLIVHTVR
>NZ_CP049748.1|WP_037150753.1|3869463_3872325_+|alpha/beta-fold-hydrolase
MPIPRPPLSRRAMTVGAAVIAVLAVAALAFVLLPQDSSADTSTRDARITLPDSPGSTGTVDIDARLYAPAVTPAPTVLLAHGFGGSKDSVDGEARDLAARGYTVLAYSARGFGDSTGSISINDPDREVADARGLIDWLAEQPEVELDAPGDPHIGVAGGSYGGALALSAGGTDPRIDSIAAAITWNDLGQALFPNYGVTSTEGREALGDTVTPAAAEYGGPGVLKRGWAGVFFGAGAASTPPGDGDDSGDAGTETSGTGEGASACGRFSPEFCDAYAQSAVTGIPSQQLLDLLTAHSPVAVASNITAPTLLVQGTQDTLFGLDQADATARQIAAAGGNVTVRWFDGGHDAGGTDGTSDRAIADFFDTTLRDNDTASGGQPFVYSTQRAADERGGDRNRRMTAPDYPGLAADSDATRTESVTFTPKAENQSIIRPPGASPSAISSVPGLGSVLSTLGSTGAGAALTADLPGQSATFTSDPVDSSVTITGVPRVNLRVASLASPGQAVLFAKLYDVAPNGTRTLPGGAVSAIRLPDTEGIDPVDVTVALPGISYTVQQGHHLELSVSTTDQAYAVPLEPAQFSVAMTDNTIALPTVPAEESANSTVPVAPLIGIGVVLLAVAGAIVAGVVRTRRRAVAEVDESLIDTPLVITDLAKTYSNGFRAVDGVSFEVKQGQVLGLLGPNGAGKTTTLRMLMGLITPTGGDIRVFGHKVTPGAPVLSRLGSFVEGSGFLPHLTGTQNLRLYWEATGRPIEDAHLEEALEIADLGTAIERKVKSYSQGMRQRLAIAQAMLGLPDLMVLDEPTNGLDPPQIRTMRDVLINYAKTGRTVLVSSHLLAEVEQTCTHVVVMNRGSVISSGTVRELTAAGGQTEIRVDDATRARSVLGASGHDGAVIVDDGTVTVDLTDADSAVVIRELVTAGVSVRGFSQSTRLEDVFLDLVHRDTPRSDTSKDRS
>NZ_CP049748.1|WP_032404014.1|3872321_3873179_+|ABC-transporter-permease-subunit
MSTAHADGRAAGYTGGSTLPFRTELRRQLGRRRTQLAIGFLALLPVILAIAFTVGSSSADSDAGGLIELGTRGGMNFTVFALFMSVGFLLIVVVALFFGDSVASEASWSSLRYLLAIPVPRSRLLTQKALVSATLSSAAIVVLVGVSLLIGTVMYGAESLITPLGEGLSYGTSLVRLLIAVAYIGINLLWVAGLAMLLSVLTDAPLGAVGGAVMTSILMQILDQITALGSLRNYLPGHYANSWIDAFGTSIDWNDMVVGSFSAITYAAVFGLIAWRRFATKDITS
>NZ_CP049748.1|WP_037150754.1|3873185_3874052_-|hypothetical-protein
MDATTAGRTSRALELIHSMTYFLPETQDALVAAGLPPRACYFAGRAAPLGRVGAGVVTATFYNFNRELVAPLIPAAWDIASPDEIMAIRYETLDAAFGRLLGPEVLTSADMAEAADLASIAARGIPGDDGRPLYAAYSELDWPTAPHLVLWHALTLIREYRGDGHIAALQAAGLSGLEALITHTATGYGFEKEFARKRRGWSTEQWDGAVASLADRELLSSDGALTQDGKDLRTLVEDITNDLAVAPWAALGEDGAARLVSLATPWRESIVGQGVIPDGVFGPAIKKN
>NZ_CP049748.1|WP_032378966.1|3874116_3876279_-|excinuclease-ABC-subunit-UvrB
MAFASEHPVVAHSEHRPVGAIERTGPAFEVVSEHVPAGDQPTAIAELERRIKADEKDVVLLGATGTGKSATTAWLIEKLQRPTLVMAPNKTLAAQLANELRDMLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATASLLSRRDVVVVASVSCIYGLGTPQSYVDRSIELEVNVEVQRDALLRLLVDVQYTRNDMAFTRGSFRVRGDTVEIIPSYEELAIRIEFFGDEIEALYYLHPLTGDIVRQVDSVRIFPATHYVAGPERMERAVKDIEAELEARLAELEGKGKLLEAQRLRMRTQYDLEMIKQVGFCSGIENYSRHIDGRGAGTAPATLIDYFPEDFLLVIDESHVTVPQIGAMYEGDMSRKRNLVDFGFRLPSATDNRPLTWEEFTQRIGQTVYLSATPGKYELGQTGGEFVEQVIRPTGLVDPQVVIKPTKGQIDDLVHQIRERAEKDERVLVTTLTKKMSEDLTDYLLELGIRVRYLHSDIDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSGTSLIQTIGRAARNVSGEVHMYADKMTDSMTYAIEETERRREKQIAYNKERGVDPQPLRKKIADILDQVYQEAEDTDNVVEIGGSGRNASRGRRAQGEAGRSVSSGVYEGQDVSSMPRAELADLIKNMTDQMMNAARELKFELAGRLRDEIQDLKKELRGMDAAGLK
>NZ_CP049748.1|WP_037150755.1|3876357_3876903_+|DUF402-domain-containing-protein
MVAHTSAGAHAVVHAPKHETFDLVAKTNVDPKGFVRVVDEYRVEPWGLYMARPSDHAHFDYLESWLLPALGLRASVFHYLPAHARDQDYYVDIGEYTAGSTRWTSVDHYLDLSVRTGRDYDLLDVDELFDARVAQHLDTPTAELALARSITAIEGLTRHDYDLNAWLASVGMPTEWNGKPT
>NZ_CP049748.1|WP_037150758.1|3876919_3878137_-|dephospho-CoA-kinase
MLRLGLTGGIGAGKSTVAKVLTELGGVLVDSDVLAREVVEPGTLGLQQLTDTFGADILAPDGSLDRPALAAVAFGNEESRKKLNGIVHPLVGQRTAEIIDGASSDAIVVQDIPLLVEGSMGPFFHLVVVVWVDAEERVRRLTGQRNMPEADARARIAAQATDDARRAAADVWIDNTGAPGSVDEQVRLLWNERLIPFERNIREGIVARTHPEQVTADPAWELQARRIIGRLALACADEAVRIDHVGSTAVPGLDAKDVIDIQITVRSLDDADAVGDRLRLAGFPGVETSNFDDPKPAYGMGGEADPAVWGKRFHGNADPGRPANVHIRVDGWPNQTFALLFRDWLREDSSVATEYSGIKRRASEVAAGIKDYRAAIEAYENAKAPWFDVAYRRAWQWAEQTNWTA
>NZ_CP049748.1|WP_032378969.1|3878266_3878476_+|hypothetical-protein
MRSNQIQPGRHRLGMDAGVHCVLIPEVASALADHRRNWFTNLLTPARHSFASMRKRTESVGQWSPATAA
>NZ_CP049748.1|WP_027497255.1|3878638_3880117_-|30S-ribosomal-protein-S1
MPSTTTSPQVAVNDIGSAEDFLAAIDATIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTEGVIPSRELSIKHDVDPNEVVSVGDEIEALVLTKEDKEGRLILSKKRAQYERAWGTIEELKEKDEAVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYVGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLHQLQKGQVRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGTEVTVEVLDVDLDRERVSLSLKATQEDPWRQFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVGVGDDALVKVIDIDLERRRISLSLKQANEDYAEEFDPSKYGMADSYDEGGNYIFPEGFDSETNEWLEGYEKQREEWEGRYAEAERRHKMHTAQMEKTAKDEAAEAANTNYSSESGQAPADAEGDAPAASAPASTGGSLASDAQLAALREKLSGNA

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Crispr_ID: NZ_CP049748_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049748_6

4783509-4783595

Orphan

Consensus_repeat	Method
AATGGACCCTTGCATACGTCTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049748_6

>merge|NZ_CP049748|6|4783509-4783595|CRISPRCasFinder
AATGGACCCTTGCATACGTCTGAAGAGTGCAATGGTTCATTCACGCGCACCCCGGACACGAGTGAATGGACCCCTGCATACGTCTGA

>NZ_CP049748|6|6|4783509-4783595|CRISPRCasFinder
AATGGACCCTTGCATACGTCTGA	AGAGTGCAATGGTTCATTCACGCGCACCCCGGACACGAGTG
AATGGACCCCTGCATACGTCTGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049748.1\|WP_080734507.1\|4779625_4783432_+\|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit	unknown	unknown	gnl\|CDD\|237030
NZ_CP049748.1\|WP_037153360.1\|4788802_4789777_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270324
NZ_CP049748.1\|WP_032403036.1\|4790924_4791590_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP049748.1\|WP_037153351.1\|4783665_4784316_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP049748.1\|WP_032403040.1\|4785953_4786787_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187593
NZ_CP049748.1\|WP_037153363.1\|4789776_4790928_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224050
NZ_CP049748.1\|WP_037153347.1\|4771998_4772718_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_037153357.1\|4786799_4787753_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|369561
NZ_CP049748.1\|WP_037153354.1\|4784385_4785957_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224983
NZ_CP049748.1\|WP_037153799.1\|4792385_4793546_-\|NADP-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|223358
NZ_CP049748.1\|WP_032403832.1\|4770142_4770886_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|378940
NZ_CP049748.1\|WP_080734506.1\|4768794_4769472_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP049748.1\|WP_052058640.1\|4770952_4771969_+\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|223512
NZ_CP049748.1\|WP_165430254.1\|4775786_4779515_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP049748.1\|WP_037153793.1\|4773711_4774788_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP049748.1\|WP_032403035.1\|4791586_4792279_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224095
NZ_CP049748.1\|WP_052058642.1\|4787708_4788596_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270324
NZ_CP049748.1\|WP_032403829.1\|4774784_4775555_+\|ABC-transporter-permease-subunit	unknown	unknown	unknown
NZ_CP049748.1\|WP_008714360.1\|4769765_4769969_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP049748.1\|WP_052058641.1\|4772761_4773601_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274681

Protein	Function_ID	Function_description	E-value
NZ_CP049748.1\|WP_080734507.1\|4779625_4783432_+\|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0
NZ_CP049748.1\|WP_032403036.1\|4790924_4791590_+\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	1.21506e-44
NZ_CP049748.1\|WP_037153351.1\|4783665_4784316_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.47015e-10
NZ_CP049748.1\|WP_037153360.1\|4788802_4789777_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.59349e-117
NZ_CP049748.1\|WP_037153363.1\|4789776_4790928_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	1.57786e-132
NZ_CP049748.1\|WP_037153357.1\|4786799_4787753_+\|alpha/beta-hydrolase	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	3.74945e-53
NZ_CP049748.1\|WP_037153354.1\|4784385_4785957_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	1.27106e-107
NZ_CP049748.1\|WP_037153799.1\|4792385_4793546_-\|NADP-dependent-malic-enzyme	gnl\|CDD\|223358	COG0281, SfcA, Malic enzyme [Energy production and conversion].	8.21773e-165
NZ_CP049748.1\|WP_032403832.1\|4770142_4770886_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|378940	pfam12746, GNAT_acetyltran, GNAT acetyltransferase. Many of the members are annotated s being Zwittermicin A resistance proteins, whereas others are listed as being GNAT acetyltransferases. The family has similarities to the GNAT acetyltransferase family.	0.000151497
NZ_CP049748.1\|WP_080734506.1\|4768794_4769472_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.82948e-10
NZ_CP049748.1\|WP_052058640.1\|4770952_4771969_+\|glutathione-S-transferase	gnl\|CDD\|223512	COG0435, ECM4, Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	7.64272e-144
NZ_CP049748.1\|WP_165430254.1\|4775786_4779515_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	7.48721e-149
NZ_CP049748.1\|WP_037153793.1\|4773711_4774788_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	8.8254e-88
NZ_CP049748.1\|WP_032403035.1\|4791586_4792279_+\|ABC-transporter-permease	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	1.25986e-57
NZ_CP049748.1\|WP_052058642.1\|4787708_4788596_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.31613e-50
NZ_CP049748.1\|WP_032403040.1\|4785953_4786787_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187593	cd05332, 11beta-HSD1_like_SDR_c, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs. Human 11beta_HSD1 catalyzes the NADP(H)-dependent interconversion of cortisone and cortisol. This subgroup also includes human dehydrogenase/reductase SDR family member 7C (DHRS7C) and DHRS7B. These proteins have the GxxxGxG nucleotide binding motif and S-Y-K catalytic triad characteristic of the SDRs, but have an atypical C-terminal domain that contributes to homodimerization contacts. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.58985e-58
NZ_CP049748.1\|WP_008714360.1\|4769765_4769969_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	5.54795e-34
NZ_CP049748.1\|WP_052058641.1\|4772761_4773601_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274681	TIGR03620, F420_MSMEG_4141, probable F420-dependent oxidoreductase, MSMEG_4141 family. Members of this protein family, related to F420-dependent oxidoreductases within the larger family of a bacterial luciferase (an FMN-dependent enzyme), occurs only within the small subset of species that synthesize F420. Most such proteins are from members of the Actinobacteria, but at least one species, Sphingomonas wittichii, belongs to the Alphaproteobacteria. [Unknown function, Enzymes of unknown specificity].	9.28468e-126

>NZ_CP049748.1|WP_080734507.1|4779625_4783432_+|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit
MSSSSTTQFGQNQWLVDEMYQRFKQDPSSVDASWHEFLTGYDPEAVTDETAGSSNGASGNGNGAASNGSSAKSAPPAAPAPPAKPAASAPQKDSTPKADAPKAAPKAAAPKAEPAKPAAAAQPAEKKAAPAKSAPAAAEFGEESSKILRGAAAAVAKNMSASLQIPTATSVRAIPAKLMVDNRLVINNHLARTRGGKISFTHLLGYAIVQAVKAFPNMNRHFAEVDGKPNAVTPAAINLGLAIDLPGKDGNRSLVVAAIKNTQDFTFTQFYNAYEDIVRRARDGKLTGEDFQGVTISLTNPGGIGTVHSVPRLMNGQGAIIGAGAMEYPAEFQGASDERLAEFGVGKLMTLTSTYDHRIIQGAESGDFLKTIHNLLISDEFYDELFHSLKIPYEPIRWRKDLPEGTVDKNTRVLELIAAYRNRGHLMADTDPLQFTKDKFRMHPDLDVISHDLTLWDLDREFKVGGFHGRDKMKLRDVLSVLRDSYCRHVGVEYTHILETEQVSWLQERVEAKHVKPTVAQQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAEAVIPMMDSVIDQSAEYALDEVVIGMPHRGRLNVLANIVGKPYSKIFTEFEGNMNPAAAHGSGDVKYHLGAEGTYIQMFGDNDIKVSLTANPSHLEAVDPVLEGLVRAKQDLLDKGTGQGGYSVLPLMLHGDAAFAGQGVVAETLNLSDLRGYRTGGTVHIVVNNQVGFTTSPEFSRSSEYCTDVAKMIAAPIFHVNGDDPEACAWVAQLAVDFRQKFHKDVVIDMICYRRRGHNEGDDPSMTQPAMYDVIDTKRSVRKSYTESLIGRGDISLKEAEDALRDYQGQLERVFNEVRELEKYTPEPSESVELDQQLPAKLTTAVDKAVLHRIGDAHLDVPDGFNVHPRVKPVLEKRREMAHEGKVDWAFGELLALGSLVDEGRNIRFSGQDTRRGTFTQRHSVIIDRKTGAEYTPLQNIGSDNPGKFMVYDSALSEFAAVGFEYGYSVGNPDALVMWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVLLLPHGHEGQGPDHTSGRIERFLTLCAEGSMTVALPSTPANYFHLLRRHARDGIRRPLIVFTPKSMLRNKAAVSNIEDFTDGKFHSVFDEPTYDTGTGDRSAVKRVLMVSGKLYYELLARKQKDNREDVAIVRVEQLYPVPVRRIREALESYPNATEFRWVQEEPANQGAWPFFGLALPELMPEKLVGIKRISRRAMSAPSSGSSKVHAVEQLEIIDEAFKAVGED
>NZ_CP049748.1|WP_165430254.1|4775786_4779515_+|ABC-transporter-ATP-binding-protein
MLHRRTALGALGVTMIAAVIDISFPLLTRVAIDDATAGKGDVILTVAVAIALLGLVRFACQFGRRMLAGRLSIDVQHDLRLDLLASLQRLDGRKQDEIRTGQVVSRSITDLQLVQGLLAMVPLSAGAILQFVLALVVMAYLSPLLTVVAILIVPAVSIVVYRMRPTLFAATWSAQQRAADLAQHVEETVTGVRVVKGFGQEARAVDRIEQLGRTLFAERMRSAKINSRFAPSMATIPQLGLVGVIALGGYLALQGHITIGTFLAFATYVATLSAVTRTVSSVVIMAQLSRAAVERVYEVVDTEPSDPEPARPLPLPDGPLGVRIREVTFGFEPERDVLTDLSLTISPGETVAVVGHAGSGKTALALLLPRFYRPAEGHIELTSDGTSIDIDDLDSTSLREAVSLVFDEPFLFSDTIAANIALGRPDATADDIERAARLAQASTFIDALPEGYDSLVGERGLTLSGGQRQRIALARALLVEPRILILDDATSAVDAETEAAIFDALRGIRTRATLVLAHRRSTLTLADRVAVLDNGRIIDTGTVDELDRRCPLFRALLAGGDDEPGTEPAHDPIEQPTAETLWPETAPESSAEPNSVAAPGGGGGHGTAMAGAFGSLAPTPAISAAVAALPPATEDPGASGSDLRRPDPGFRLSRLLGPVRMLLAAVVVLLALDSLASIAFPSLVRYAVDSGVARGDSNTLWIATSIGVVLAAASWFVVCWTTVITARAGERVLFGLRVRSYAHIQRLGLDYYERELSGRIMTRMTTDVDALSSFIQTGASTAVVSVLTVVGIAAALLVTDLTLGLVALAVVPPLAVATVIFRRISSAAYSTSRERISIVNADFQENVTGLRAAQAYRREEYAASRFAERSDRYRSSRMRSQTAISVFFPLITLLSDIALAVVVFVGAHQIATGTTTAGTLVAFVLYLGLLFGPIQQLSQVFDGYQQARVGVGRIGDLLRTTSSIETATTANTTALPGGRLRADIDLVDVGFRYAGAHSDALSEVSLTIPAGTTVALVGRTGAGKSTVVKLLARFYDPTSGSVRVGGNDLRDYRLSDYRQRLGVVPQEAHLFTGTVASNIAYGRPDASRADIENAARSVGALTTIAALRGGMNQPVGERGQGLSAGQRQLIALARAELVDPDLLLLDEATATLDPATERTVLAASNAVVRTRTAVVVAHRLATAARADLIVVVDGGRIVETGRHSDLRAQGGFYARLWTAAETNRGNNSIVQGVIDNEADGYR
>NZ_CP049748.1|WP_032403829.1|4774784_4775555_+|ABC-transporter-permease-subunit
MNALLTSEIRKVTTLKFWWALAIAPIVVGIFASVITSVIANQLGPYEEDLDISGGVASIGLYVAAGAAILFAGIFGAVNAGTEFRHKTITTSFLTARGRDGVIAAKLIVTALFGLGYGLVVLLASLICLLIFNDRTVMLDGPFIGVVASCLLAVVLWSIIGAGLGLLLKSPTWAAIVLVAWLPFGEGLLSLILFGVGLGPVATVLPSNLTLPTMAATQLDDAGDLASWPWAPLGLALWAAILTGGGWFLARTRDID
>NZ_CP049748.1|WP_037153793.1|4773711_4774788_+|ATP-binding-cassette-domain-containing-protein
MTSYSGAALEAQALTKQFGTVRAVSDLSFVVPRGTVTGFLGPNGSGKTTTLRMLLGLVAPTSGIGLVNGAPFGAATHPAHTVGAVLDSLSMHPKRSAAHHLKIYTAAIGVPDSRALDVLHLVGLGDAAHRPAGGFSLGMRQRLTLATALLGDPEILVLDEPANGLDPEGIAWLRDFLKAFAASGRTVLISSHILREIEQTVDNLVIVSAGSLMYQGSIAQLRSTRPSRVLVAASDPATLAIALASNGLNDTQLLPDGRIGVAGTDAATITRIAATADVTVFGTTAEHVDLEQVFLSMTAGQYTAAPVGQNPYGPPPGQPQGYAPPPNYGPPPGYGPPPGYGPPPPEYGPPQNWNGGRR
>NZ_CP049748.1|WP_052058641.1|4772761_4773601_+|LLM-class-F420-dependent-oxidoreductase
MTSTPELGKYGVWRLHSAFTPELSRAIESFGYGTIWLGGSPPADLTTTEEILDATETVVVATGIVNIWSDAAADVAQSYHRLEKKHPGRFLLGIGAGHPEATQEYTKPYDALVAYLDELDTAGVPVERRVLAALGPKVLALAADRTAGAHPYLTTPEHTREAREALGPNKILAPEHKVVLESDPQKARAIGRPPVNNPYLHLRNYTNNLNRLGYSDDEIGDGGSDRLIDALVAHGTADAIAARLKEHLAAGASHVTLHSLPDDADPLETYRDIAAALLR
>NZ_CP049748.1|WP_037153347.1|4771998_4772718_+|hypothetical-protein
MAGKKDDAQVEVSNGGRLERALVNILDNASRLQGPAVDKYVAHVRRAHPYDTPAQIIERLEKRFLLAVTGSGSAVGGAAAVPGIGTAASLAAVGAETAFFIESSALLTLSVASVHGIPVENHQQRRALVLSVALGESGMQIVQRTVGKTAKNWGPLITSRIPGGAMTSMNKSLVKKFITKYLAKRSALLVGKMLPAGIGAAIGGAGNRAVGKGVIKNAREAFGPPPARFPENRIIEPDE
>NZ_CP049748.1|WP_052058640.1|4770952_4771969_+|glutathione-S-transferase
MADDAAYVEPGKEFKRDTNYIPTRITADGRDGYPVEPGRYRLIAARACPWAHRSIIVRRLLGLEDVLSLGIPGPTHDPRSWNFQEEPGGIDSVLKIERLQDAYFARFPDYERGITVPAIVDVPTGEVVTNDYPQITLDLSTEWTQYHRDGAPDLYPEALRGEIDEVADLVFEDVNNGVYRCGFAGSQEAYDKAYDRLFARLDWLVERLSTQRYLVGDHITEADVRLFTTLVRFDPVYHGHFKCNRSKLSEMPVLWNYARDLFQTPGFGDTVDFDHIKRHYYEVHRDINPSGIVPKGPDLQGWLEPHGRESLGGSPFGDGTAPPPPKPDELVPATHWVH
>NZ_CP049748.1|WP_032403832.1|4770142_4770886_+|GNAT-family-N-acetyltransferase
MDFPLFDAGRFDSHKLDIVRLAWCRQLGLDDTALDTDADRVEHLVSTDNVTVLSLAGTTVIAGPSWAVDASRSITGRPGADRTWMSSLLGDRSAHYEIGTHSLAYGSDIGHSIDVHDPLISHDAVHVRNLAAKCDDADVAEAFGESVSRNWFTLLGDDRPADSAHSLASAGYSEEQLILADMRVLTDPIHRRRGHAQVVGRLATNDAIDEGLIPQWRSRPENSIARRLAARLGYTELGVCHTAVVRA
>NZ_CP049748.1|WP_008714360.1|4769765_4769969_-|cold-shock-protein
MTQGSVKWFNGEKGFGFIEQDGGGPDVFVHYSEIQGSGFKSLDEGQRVEFEVGQGQKGPQATGVRAI
>NZ_CP049748.1|WP_080734506.1|4768794_4769472_-|PadR-family-transcriptional-regulator
MRGDAVNLLGVSVLALLSEAPMHPYEMYQLLLERKEDRIVKIRPGSLYHAVARLHGQELIAEVGTDRGGNRPERTTYEITPAGRQVLVDRLAEILRSPVREYPQFTLGLSEMHNLPASEAIALLRARIEDLAREIEELSGFQRLARERKTSEIYWAGIDYTYHMLAAEVKWLTSYIDRLDSGELEWPHAISAQHTTLTDRHRPHDPDTSGHCHTTPTPRGTRRTL
>NZ_CP049748.1|WP_037153351.1|4783665_4784316_-|TetR/AcrR-family-transcriptional-regulator
MAFVNSPGATTKRTRLSPEQRRAQLIELGTEMLADRPLEQISVEDIADQAGVSRGLLFHYFSSKQEFHLEIVREASRSMIERTAPDPDLEPFEILRDSIANYVDYVTEKRDTFISLLRGTASGDPLMREVFEQTRTTMAERTLVQLAGLDMDVTPTIDLAVRGWIAFVEEATITWLRDPHISRDELIDLNVNALPAVALAPSMISALLGADSDADA
>NZ_CP049748.1|WP_037153354.1|4784385_4785957_+|NAD(P)/FAD-dependent-oxidoreductase
MSLPVTDTSDRATSPRHVDTLIIGSGFAGLGAAIKLTKAGKKDFVVIERGHDVGGTWRDNTYPGAACDVPSHLYSYSFALNPDWTRSFSTQPEIQKYIAGVARKYGVMDKHVFGTDVTSARWNAETNRWDVETTSGNYTAKIVVSAVGALCEPNLPDIKGIHDFEGDVFHSAQWNHDVSLAGKRVAVIGTGASAIQIVPAIAGQVKHLDVYQRTAPWILPRADRPYTKLERFAFKHVPGFQRLSRAGIYAMRETQVVGLAKAPAFMKPLQWASENHLRTQIKDKALRAKVTPNFRIGCKRMLISNAYYPALAQSNVDLVTDGIAGVRKGSIVTKDGTERPIDALVVATGFHVTDSPAYQGITGKDGRTLAETFDDGGQQGYKGAAVANFPNMFFLVGPNTGLGHTSMVFMIESQINYLVDALNTIDKHDIGTIEVRKDVQDEYNVTLQDQLSKSVWMNGGCASWYLDKHGNNTTLWPGFTFEFRRMTKQFDLDAYRSVASADLSSGSSADTGTGNNTDKVAAR
>NZ_CP049748.1|WP_032403040.1|4785953_4786787_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSTFTGKVAVVTGAGSGIGRALALELAGRGAKLALSDVDTAGLDETVRRVEALGAEVKSDFLDVSQRETVLDYAEAVVAHFGKVNQIYNNAGIAYHGDVDKSSFKDIERIVDVDFWGVVNGTKAFLPHIQASGDGHIINISSLFGLLAIPSQSAYNAAKFAVRGFSESLRMEMLISKAPVKVTVVHPGGIKTAIARNATVAENYDQADFAKFFDTKLAKTTPLDAAKTILKGVEKGKGRVLIGSDAIALDLLQRITGSRYQGLIVAVSRRALPRTKK
>NZ_CP049748.1|WP_037153357.1|4786799_4787753_+|alpha/beta-hydrolase
MKAFYVPLPIVAAALKPFYRLALNPRFSFRTQRMILEAGAPLQTLPHGTVAQKLTLAGRKAERVTVGATERDTAILYLHGGAYTIGSINTHRSLAAHLARESASAVYVLDYRLAPENPYPAGLDDAVAAFRELVRLHGFTPDRIAIAGDSAGGGLTVATARRLVDDGTSPAALGLISPWVDPGARDAPKDRDLVVNTGWSYSSADAYLGAGDPLDQGFAPLLGNLDGLPPIVMHVGTDEVLYAQITAFADKLRLSGAELEHVEYKKLWHVAHLQASILREAAEAVQHMGAYLGRKVRASTNDASQVVLTEPAASDIA
>NZ_CP049748.1|WP_052058642.1|4787708_4788596_-|ABC-transporter-substrate-binding-protein
MRSSVLATAVVVSIAGLLGGCSTAESADPAGEPIVVGSGSTDISRLLAQIYAGGLRSTGVDVEVKDGLGDRANYLAALDRGEVSMVPDLTGDLLRTFDTLAGATEAEDVFTELNRSLPAGLSVGDYATAEDRLAIAVAPDSASDDGETVTDFLRRGESTVGLVDGQVDPMDVVSVSRSSPTFTGASFTDFTPYFDGQASVDGLNAGEVGALAIRTASFGPLAKDLTTLPDDEHVYPAQNVVPLYRNGVLSESALRSFSVVAGELTTADLADMIGEVRSGVASGDVAGRWLGEHNL
>NZ_CP049748.1|WP_037153360.1|4788802_4789777_+|ABC-transporter-substrate-binding-protein
MTTSRITRAFSAPKAVAAVAALALSVTALTACGGNSDPLSSGGGETNSDTNSIIIGSANFPESETVANIYAEALRANGFEVSTKLNIGSREAYIPAVRDGSIDMIPDYTGNLLQYLDESATATSSEDVLAALPAALGDDLTVTAQAPGEDKDAVVVTRQTATARNLTTIGDLAPFSSDVTFAGTPEFQERVGGLPGLRDKYGLDISAGNYIPISDGGGPATVEALVSGQVVAADIFTTSPAIAQNDLVVLEDPENNFAAQNIIPVLRTAKQSDKLTQVLDAVSAQITTDELIALNTSVSGDEKVEPAAAAAAWVKDKGLDQPVS
>NZ_CP049748.1|WP_037153363.1|4789776_4790928_+|ATP-binding-cassette-domain-containing-protein
MITFEHVNKTYQDGTTAVDSLDLVIEPHSFTVFVGPSGCGKTTSMRMINRMITPTSGVITVDGRNIADTDAVKLRRGIGYVIQSAGLLPHRTVVDNVATVPVLNGESRRAARKAALDVLERVGLDPAFASRYPAQLSGGQQQRVGVARALAADPPILLMDEPFSAVDPVVREELQTEMLRLQADLKKTIVFVTHDIDEAVRLGDHIAVFGPQGRLQQYDKPETVLAAPATPFVAGFVGRDRGYRGLSFRSAQSVTMHPIHTAVQDEVSSLRLDQGQWVLVVDSQRRPLGWIDASGVEKVRDGRSIDESTAAGGSLFLEGGDLRQALDSAISSPSGIGVAVDSSGAAVGSVDGAEILENLAAQRKSEDSERNRHHFLTAGDTDQ
>NZ_CP049748.1|WP_032403036.1|4790924_4791590_+|ABC-transporter-permease
MTWLFDNFDVVLGYTKTHLYLSLVPLFVGLLIAIPLGTVIRNTRWVRRITLTVASIAFTLPSLALFVTIPAVVGLPVLDPLNVVIALAVYSTALLVRAVPEALDSVPFAVVDSAEAMGYSTLRRAVTVELPLALPVLIANIRVVAVTNISLVSVGSVIGIGGLGQLFTQGYQRDYPDQIFAGIISIVFLALVFDAALFLLGRRLTPWTRLGTGSSKKKARA
>NZ_CP049748.1|WP_032403035.1|4791586_4792279_+|ABC-transporter-permease
MNLFSEAFSYILDGGNWSGPTGIGARLIEHMWYSLLAVLLSAVIAVPIGLLIGHLRRGEAVIVGLVNALRSLPTLGILVFLVLVIGLGLVPPIIALVLLGIPPLLAGTYSGIANVDANVVDAARAMGMTETQVLLRVEIPNALPLILGGLRNTTLQIIATATIAAYVNLGGLGRYIFDGLALYDYQRVLVGAILVAVLTLVVDGLLALAVWTSVPGTGRLRRMPTGLAKV
>NZ_CP049748.1|WP_037153799.1|4792385_4793546_-|NADP-dependent-malic-enzyme
MPAAITDEEIFAGHLGGKLSVELAAPLETQRDLSIAYTPGVAQVSRAIAADPALAKRYTWTDRLVAVISDGSAVLGLGDIGPRASLPVMEGKAALFKKFAGLDSIPIVLDTNDVDEIVETIVRLRHSFGAVNLEDISAPRCFEIERRVIEALECPVMHDDQHGTAIVVLAALNGAAKVQGRSTSELKVVVSGAGAAGVACANMLLLAGIPDVVVLDSKGIVSSDRHDLTSVKTDLAARTNPRALSGGVAEALAGADVFLGLSAGKVDEGCIASMAPESIVFALSNPDPEIHPEVARKYAAIVATGRSDFPNQINNVLAFPGVFKGALDAGARRITEGMKLAAAEAILSVLGDELAADKIVPSPLDPRVAPAVADAVAAAARAEGVA

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Crispr_ID: NZ_CP049748_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049748_7

5177080-5177168

Orphan

Consensus_repeat	Method
GCCTTCTTGGCCGGAGCCGGGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP049748_7

>merge|NZ_CP049748|7|5177080-5177168|CRISPRCasFinder
GTCTTCTTCGCCGGAGCCTTCTTGGCCGGAGCCGGGGTGGCCTTCTTCGCAGCCGGTGCCGGTGCCGTCTTCTTGGCCGGAGCCGGGGT

>NZ_CP049748|7|7|5177080-5177168|CRISPRCasFinder
GTCTTCTTCGCCGGAGCCTTCTT	GGCCGGAGCCGGGGTGGCCTTCTTCGCAGCCGGTGCCGGTGCC
GTCTTCTTGGCCGGAGCCGGGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049748.1\|WP_032380350.1\|5170361_5170865_+\|DUF2505-domain-containing-protein	unknown	unknown	gnl\|CDD\|378476
NZ_CP049748.1\|WP_032380348.1\|5171650_5172238_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227645
NZ_CP049748.1\|WP_032401832.1\|5180522_5181068_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153228
NZ_CP049748.1\|WP_052058179.1\|5179739_5180477_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP049748.1\|WP_037148739.1\|5184675_5184951_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_052058177.1\|5177850_5178318_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_CP049748.1\|WP_080730773.1\|5178391_5179657_-\|DUF445-family-protein	unknown	unknown	gnl\|CDD\|225347
NZ_CP049748.1\|WP_032401830.1\|5182615_5183473_+\|polyphosphate-kinase-2-family-protein	unknown	unknown	gnl\|CDD\|274737
NZ_CP049748.1\|WP_037148731.1\|5173156_5173816_-\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|234784
NZ_CP049748.1\|WP_080730774.1\|5172381_5173095_+\|DUF2993-domain-containing-protein	unknown	unknown	gnl\|CDD\|378597
NZ_CP049748.1\|WP_080734301.1\|5170869_5171643_+\|SAM-dependent-methyltransferase	unknown	unknown	unknown
NZ_CP049748.1\|WP_032380785.1\|5182120_5182582_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_CP049748.1\|WP_032401827.1\|5185016_5185892_-\|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|181133
NZ_CP049748.1\|WP_037148738.1\|5181084_5182074_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP049748.1\|WP_037148734.1\|5173866_5174709_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|225136
NZ_CP049748.1\|WP_032401836.1\|5174722_5175607_+\|formyltetrahydrofolate-deformylase	unknown	unknown	gnl\|CDD\|235676
NZ_CP049748.1\|WP_032401840.1\|5169840_5170350_+\|DUF2505-domain-containing-protein	unknown	unknown	gnl\|CDD\|378476
NZ_CP049748.1\|WP_032401834.1\|5176709_5177003_-\|DUF2516-family-protein	unknown	unknown	gnl\|CDD\|378483
NZ_CP049748.1\|WP_032401829.1\|5183538_5184579_-\|NAD(P)-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176186
NZ_CP049748.1\|WP_037148737.1\|5175603_5176629_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669

Protein	Function_ID	Function_description	E-value
NZ_CP049748.1\|WP_032380350.1\|5170361_5170865_+\|DUF2505-domain-containing-protein	gnl\|CDD\|378476	pfam10698, DUF2505, Protein of unknown function (DUF2505). Members of this family are all Actinobacteria. The function is not known.	7.70168e-51
NZ_CP049748.1\|WP_032380348.1\|5171650_5172238_-\|hypothetical-protein	gnl\|CDD\|227645	COG5340, COG5340, Predicted transcriptional regulator [Transcription].	5.56552e-05
NZ_CP049748.1\|WP_032401832.1\|5180522_5181068_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153228	cd03134, GATase1_PfpI_like, A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus. This group includes proteins similar to PfpI from P. furiosus. and PH1704 from Pyrococcus horikoshii. These enzymes are ATP-independent intracellular proteases and may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For PH1704, it is believed that this Cys together with a different His in one monomer and Glu (from an adjacent monomer) forms a different catalytic triad from the typical GATase1domain. PfpI is homooligomeric. Protease activity is only found for oligomeric forms of PH1704.	3.62553e-80
NZ_CP049748.1\|WP_052058179.1\|5179739_5180477_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.63792e-11
NZ_CP049748.1\|WP_052058177.1\|5177850_5178318_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.47372e-13
NZ_CP049748.1\|WP_080730773.1\|5178391_5179657_-\|DUF445-family-protein	gnl\|CDD\|225347	COG2733, COG2733, Predicted membrane protein [Function unknown].	6.18063e-146
NZ_CP049748.1\|WP_032401830.1\|5182615_5183473_+\|polyphosphate-kinase-2-family-protein	gnl\|CDD\|274737	TIGR03709, PPK2_rel_1, polyphosphate:nucleotide phosphotransferase, PPK2 family. Members of this protein family belong to the polyphosphate kinase 2 (PPK2) family, which is not related in sequence to PPK1. While PPK1 tends to act in the biosynthesis of polyphosphate, or poly(P), members of the PPK2 family tend to use the terminal phosphate of poly(P) to regenerate ATP or GTP from the corresponding nucleoside diphosphate, or ADP from AMP as is the case with polyphosphate:AMP phosphotransferase (PAP). Members of this protein family most likely transfer the terminal phosphate between poly(P) and some nucleotide, but it is not clear which. [Central intermediary metabolism, Phosphorus compounds].	4.13672e-142
NZ_CP049748.1\|WP_037148731.1\|5173156_5173816_-\|deoxyribose-phosphate-aldolase	gnl\|CDD\|234784	PRK00507, PRK00507, deoxyribose-phosphate aldolase; Provisional.	2.00027e-100
NZ_CP049748.1\|WP_080730774.1\|5172381_5173095_+\|DUF2993-domain-containing-protein	gnl\|CDD\|378597	pfam11209, DUF2993, Protein of unknown function (DUF2993). This family of proteins with unknown function appears to be restricted to Cyanobacteria.	3.0574e-12
NZ_CP049748.1\|WP_032401834.1\|5176709_5177003_-\|DUF2516-family-protein	gnl\|CDD\|378483	pfam10724, DUF2516, Protein of unknown function (DUF2516). This family is conserved in Actinobacteria. The function is not known.	5.60707e-25
NZ_CP049748.1\|WP_032380785.1\|5182120_5182582_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	1.48812e-29
NZ_CP049748.1\|WP_032401827.1\|5185016_5185892_-\|3-hydroxybutyryl-CoA-dehydrogenase	gnl\|CDD\|181133	PRK07819, PRK07819, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	7.50823e-180
NZ_CP049748.1\|WP_037148738.1\|5181084_5182074_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	4.35212e-52
NZ_CP049748.1\|WP_037148734.1\|5173866_5174709_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|225136	COG2226, UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism].	2.59836e-18
NZ_CP049748.1\|WP_032401836.1\|5174722_5175607_+\|formyltetrahydrofolate-deformylase	gnl\|CDD\|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	6.36932e-177
NZ_CP049748.1\|WP_032401840.1\|5169840_5170350_+\|DUF2505-domain-containing-protein	gnl\|CDD\|378476	pfam10698, DUF2505, Protein of unknown function (DUF2505). Members of this family are all Actinobacteria. The function is not known.	2.23324e-56
NZ_CP049748.1\|WP_032401829.1\|5183538_5184579_-\|NAD(P)-dependent-alcohol-dehydrogenase	gnl\|CDD\|176186	cd05283, CAD1, Cinnamyl alcohol dehydrogenases (CAD). Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH- dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0
NZ_CP049748.1\|WP_037148737.1\|5175603_5176629_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.00544e-33

>NZ_CP049748.1|WP_032401834.1|5176709_5177003_-|DUF2516-family-protein
MSIAGSFSYYILTFLQILGVVGAGFAIFHALRQRADAFPAVDKLTKTAWLAILFVGLLLILVSGVIGFLGIIGVVAVCVYLVDVRPKIDSIQRGPRW
>NZ_CP049748.1|WP_037148737.1|5175603_5176629_-|alpha/beta-hydrolase
MVSRKVVERVLFGIGGSAAAASVGAFVVRRRRLHSFTKTTDVRPDELLQHPTIEPHITEVVTDDGAHLHVRSYGDADAEPIVFSHGWTCSADYWFPQINALAGRYRVIAYDQRGHGRSDVGTRPLSPDVLADDLAAVLAATVVEDNKAVLVGHSMGGMSIMAWAGNYPEQVDRLVSAVLLASTATDSLVRETTVIPLPQRFPRVPAPVGRAVLSSALPLRPSPVTRQAIKYISMAPGATAAEVAFCEKIVLECAPRTRGIWGAAISDLDIREALANMSVPTSVLVGSADRLTPPVHARKLARALDDHDHLSRLIVIPGIGHMSSVEAIDEFNTEVVRLRNL
>NZ_CP049748.1|WP_032401836.1|5174722_5175607_+|formyltetrahydrofolate-deformylase
MSSSVSEDRRYVLSLGCPDKTGIVARISTFLAEVGGWIVEAAYHADPDTGWFFTRQAVRASSVDMSIDDLRARFAEVAAELGPETEWALHDSGEPKRVVLLVSKEAHCLHDLLGRAAGGELPAQISAVIGNHKSLEPIAAAHGTPFHHVEFAKDPAERGPAFEKVRSLVDSYDPHAVVLARFMQVLPESLCAHWAGRAINIHHSFLPSFVGARPYHQAFARGVKLIGATCHYVTAELDAGPIIEQDVIRVDHSDEVTDMVRQGRDIEKLVLSRGLRWHLEDRVLVHGRKTVVFS
>NZ_CP049748.1|WP_037148734.1|5173866_5174709_+|class-I-SAM-dependent-methyltransferase
MTAASLAATFNATSREFDAVTPQVWGPAGQSLAFALELAPGDVVLDVCSGTGASAIPAAAAVGPDGIVHAIDLADDLLEVGRVKATDRALRNIDFVVADATEWQPPSTVPVAGYDALACSYGIFFLPDPEQDFARLVSLVRPGGRVGLTVWRKGSVREYSGAFFDVIGRHWPPSAGPAPDPTAEVDDHPIRRMETADLLGAWLTAAGTSDVRVVELSNHVPATQSFVWDFVLGSALRGALTPFDDGTRTQIRAEFSALLTERGIDSIDLGTLVATGVRTP
>NZ_CP049748.1|WP_037148731.1|5173156_5173816_-|deoxyribose-phosphate-aldolase
MDDMTLTRAALAGMVDHTLLKPEATTADVTALIEEGRELGVLAVCVSPSMLPIRAEGMLTAVVAGFPSGKHHSLIKGSEARLAVQQGADEVDMVIDVGAAIAGDYNAVLADIVTVREGIGNAVLKVIIESAALSDEAIVEVCRAAETAGANFVKTSTGFHPAGGASVEAVRLMAETVGGRLGVKASGGIRTTEAALAMIDAGATRLGLSGTRAVLDGLG
>NZ_CP049748.1|WP_080730774.1|5172381_5173095_+|DUF2993-domain-containing-protein
MIAVSVVVVLLVAVIGGELFVRQQIKSCLAGQLESELGSQVEVGLGLKPVLLSLVDKKVSSVTVDSDDARFGPAEGMVVHAEARDLNLTQSADSGGTIGSSSADISWSTDGITRTLQSQGIGAIVSGVTSDASAGTLEFAVGALAKLTVKPQVADGRVDFQTVDASILGLGIPTDLVDSVVGVLTDSLQAYPLDMTPTSLTVTDSGIELTLEGGQYTIPATQQNQNQQTPEGCSLVA
>NZ_CP049748.1|WP_032380348.1|5171650_5172238_-|hypothetical-protein
MGTTGPSVQELHSLATRQDGYFTAEQAGELGFDSAMVRVNLATNTWTRVERNLFRLGQWPHSELEVFAMWCAWFGGEAVISHQSAAELHGFGHLHPQFVHLCAFGDLRLSDTRLAVHRLRLEPRDVESAGTFNITTPVRTVLDLAAGGISQLTLDEVVCDAVAIGRVDPQALYSEAGSSTDRVAERVELALSACT
>NZ_CP049748.1|WP_080734301.1|5170869_5171643_+|SAM-dependent-methyltransferase
MSKPEGVITRGTTGINRLRRSDRWLMHDADVRRVLRESPDPLVVDLGYGAMPNTTLELAGRLRTVRPDLRVTGLEIDPARVVPGSDGVEFARGGFELAGLRPNLVRAFNVLRQYPEDAVPAAWQRIQSRLAPGGLLVDGTCDELGRRCAWVLLDAEGPRSLTLAWDPFDVEMPSDIAERLPKVLIHRNIEGELIHDLLQRADRAWSVSAPLAPFGPRLRWRAALKILAEQGLPITLPRRRMRDNVLTVPWATVAPAW
>NZ_CP049748.1|WP_032380350.1|5170361_5170865_+|DUF2505-domain-containing-protein
MARRMNYSARFTHSTQQVYAALSSRDHWDARIEEMRKYSENELKSFEVSDAGIDIVMHHVIPRTELPDIAQTVMKKDMVITRNVHFDAYEEVTAGHYDASIPAGPGSLKGTTSLFPTNGGSTLRTSSEAKVFLPFIGGKLEQLMLVNLIDLWRGEGEVTADWLEKNA
>NZ_CP049748.1|WP_032401840.1|5169840_5170350_+|DUF2505-domain-containing-protein
MPRPIEHSSTVPASADKVHAALTSEQYWKDRIEQIGGPGASLKSVTVGDGTIDVVMTQSVPEEELPSAVTAFKKGDLIIERTESWGPFDGTHAAGTFGATVEGAPARITGTTTLDGKGDTTTVALAGTTEVKVPIFGGKIESMISEQVLSLIDNEQDFTGNWIAAQANS
>NZ_CP049748.1|WP_052058177.1|5177850_5178318_-|helix-turn-helix-transcriptional-regulator
MAENEGDLVAKATEATQVVAEAGDLVASVVTTAAQDIGSYIRSQREAAQVSMRQLASRAGVSNPYLSQIERGLRNPSAEVLAQIAKGLRVSSEVLYVRAGILEARPHGPVREALLGDEHITERQKQVLIEIYDSFCRENESTQEPEPDEQETPDV
>NZ_CP049748.1|WP_080730773.1|5178391_5179657_-|DUF445-family-protein
MQLMNFDDDTKRRDLRKMKTVATGFLVFASIVYLFCRWQESTGAGAWVGYVRAASEAGMVGALADWFAVTALFKHPLGIPIPHTALIKKKKDQLGASLSSFVGSNFLAPEVVSEKVASAQVPLRLGTWLAQPDNAERVAAEAATVLHGVVDVLNDEDITAVIDSTIVRRLADPQWGPPIGRILDELLRENRQLPLIDMLAERAHQWALGSQEMIDRVVARDSPNWSPKFVDTLLGEKVYKELVEFTWKIRSNPEHDVRLAANKFLIDYANDLQHDPTTIEKAEKLKAQIMGREEITGLAAATWKVAKRLITESVDDPTSTLRTKIKENTVNFGIRLRDDDELRGKADGWLLGGARYIAANYADEITTIIGDTVARWDAEEASKKIELQVGRDLQFIRINGTVVGSIAGLAIYTISDLIFGH
>NZ_CP049748.1|WP_052058179.1|5179739_5180477_+|TetR/AcrR-family-transcriptional-regulator
MARNTTEAKLGESEPNEEKPKAEKPDGRKRRWREHKIARREELVDGTLAAIRLRGREIGMDEIASEIGISKTVLYRYFTDKNDLTSATMSRYVETTLAPRIYSAISHELDEYELTRVVVTAYVETVATDPEVYLYVMANNAGNNRDVVAESERMIAELLSTVLGERLRQREMDSGGSVPWAFAIVGAVQLATHWWISNKSMSADDLIDYLCMMMWGGIHGVAMADGSPAKFKSQPHPLVDEPNES
>NZ_CP049748.1|WP_032401832.1|5180522_5181068_+|type-1-glutamine-amidotransferase
MTTDTLTGRRIAILATDGVEQVELVQPREAVENAGATVTLVSLDHGDIQAMESDVHAADTFTVDRVVADVSADDFDALILPGGTTNPDQLRVDAEAVAFVRDLVAAGKPVGVICHGAWTLVEADVLKGRTLTSYPSIRTDIRNAGGTVVDEEVVVDGNLVSSRNPDDLPAFCAKIVEHFAA
>NZ_CP049748.1|WP_037148738.1|5181084_5182074_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MRISRSLALPAAALAFALTLTACSSDAGDGDSADPSEAGGIVVTDMFGDVEVPANPQRVVALGWSDAETALALGVQPVGASDWLGVGGNGLGPWVDESYDTDPTIVGTFDVDMESVAALAPDLILWTRSTNDKAVYDQLSDIAPTVAAPPGTDVAYGTTWDGQTDIVAQALGKVDEGKKLVDDTKALFDDTVSANPEFANKTVAVGTLYSGQIGAYVRGDTRVDFLESLDLTNTPAVQNLAEPGAFSIELSEENVAALDADLTVMFPIGTGPEVITDNPSIQGLPSARDGRLVVLGDQNLSNAFSAASVAGTRYALENAVPLFAAPLKG
>NZ_CP049748.1|WP_032380785.1|5182120_5182582_-|PPOX-class-F420-dependent-oxidoreductase
MAPTIAKAESATREQLLEFVSPRHHHTLITRKRDDGLQVSPVSAGVDSEGRIVIATYPERAKVLNIRRNSAVTVLVHSDDWNGDYVQVDGTAEIIDLPDAVEPLVEYFRSIAGEHSDWDEYRAAMVKQGKSLIRIVIDTWGPIAAGGFPPGRV
>NZ_CP049748.1|WP_032401830.1|5182615_5183473_+|polyphosphate-kinase-2-family-protein
MADKSKLWTQSPVDVLRASASPRVEDIDFTATPGFDGKKAHGNDVLEERGAVLAALQEKLYAHGRTGDSRSVLLVLQGMDTAGKGGMVKHVIGMVDPQGVDLASFGVPTQEEKQHHYLWRIRKALPRAGRIGVFDRSHYEDVLVVAVHDLVPREVWEQRFDEINAFEKELTDEGTIVVKVALFVSADEQKKRLQERLDRPDKYWKYNPGDVTERGFLPQYRTAYQRVLDRTDTDHAPWYVVPADRKWYSRLAVTEILIDALEQLDLDWPAPDFDVELEKKRLAES
>NZ_CP049748.1|WP_032401829.1|5183538_5184579_-|NAD(P)-dependent-alcohol-dehydrogenase
MTSATAYQATAPDAPLEKATIERRALGPNDILIDVKFAGICHSDIHTARNEWGGTTYPVVPGHEIAGIVAEVGTDVTSRKVGDRVGVGCFVDSCGECEACKDGDEQYCTKGVVQTYNSTTYEGEFTNGGYSTQIVVTEKFVLGIPEGVELDVAAPLLCAGITLYSPLKHWGAGPDKKVAIIGMGGLGHIGVKIAHAMGAHVTVLSQTDAKEADGKAYGADEYYATKDTSALKDLQGKFDLILNTVSANLPMGKYLGLLARNGTLVELGVPEKPLEVPAFNLLANRRSFAGSMVGGIAETQEMLDFCAEHHIGAEIEVIPAEKINEAYDRVVKSDVRYRFVIDAATF
>NZ_CP049748.1|WP_037148739.1|5184675_5184951_-|hypothetical-protein
MSKSKKSNGLVTKAFGIGLAATGAAHFVVPEAFEGITKLPFPEDTRTWISRNGATELAVGIAIAYPKTRKIGLVGLGAYGLWLGANIAKNG
>NZ_CP049748.1|WP_032401827.1|5185016_5185892_-|3-hydroxybutyryl-CoA-dehydrogenase
MTVERVGIVGAGQMGAGIAEVCARAHVDVLVYEQTRELATAGRSRILQSLDRGVSSGKITEREREQAACSLRFTSDLADFADRQLVVEAVLEDEKVKADIFAELDAVVIDPGAVLASNTSSIPITTLGSATTAPDRIVGLHFFNPVPVLPLVELVTTDATSEAVADRAERFAGDILGKQVVRSADRSGFVVNALLVPYLLSAIRMVESGFATKEDVDKATVLGLAHPMGPLALADLIGLDTVKAIADSMHSEFAEPLFAAPSLLLRMVEAGQVGKKSGAGFYRYENGRVAK

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Crispr_ID: NZ_CP049748_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP049748_8

5390493-5390660

Orphan

Consensus_repeat	Method
TGGCCGTACTGCGGTTGGCCGTACTGC	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP049748_8

>merge|NZ_CP049748|8|5390493-5390660|CRISPRCasFinder
CCGAACTGCTGGGGTTGGCCGAACTGCCGAGTCTCGTAACCCGGGGCCTGGCCGTACTGCGGTTGGCCGTACTGCTGAGTCTGGCCGTACTGCGGTTGGCCGTACTGCGGTTGGCCGTACTGCGGTTGGCCGTACTGCGGTTGGCCGTACTGCGGTTGGCCGTACTGC

>NZ_CP049748|8|8|5390493-5390660|CRISPRCasFinder
CCGAACTGCTGGGGTTGGCCGAACTGC	CGAGTCTCGTAACCCGGGGCC
TGGCCGTACTGCGGTTGGCCGTACTGC	TGAGTCTGGCCGTACTGCGGT
TGGCCGTACTGCGGTTGGCCGTACTGC	GGTTGGCCGTACTGCGGT
TGGCCGTACTGCGGTTGGCCGTACTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP049748.1\|WP_094738244.1\|5385121_5386966_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NZ_CP049748.1\|WP_037148963.1\|5391032_5393579_-\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NZ_CP049748.1\|WP_052058227.1\|5383162_5383624_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP049748.1\|WP_037148965.1\|5393779_5394943_+\|flavoprotein	unknown	unknown	gnl\|CDD\|99784
NZ_CP049748.1\|WP_037148967.1\|5402349_5402985_+\|5,6-dimethylbenzimidazole-synthase	unknown	unknown	gnl\|CDD\|380321
NZ_CP049748.1\|WP_037148961.1\|5386952_5387561_+\|class-F-sortase	unknown	unknown	gnl\|CDD\|320678
NZ_CP049748.1\|WP_155292546.1\|5398724_5399924_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|179663
NZ_CP049748.1\|WP_037148953.1\|5381712_5382351_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377946
NZ_CP049748.1\|WP_032401529.1\|5383620_5384847_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NZ_CP049748.1\|WP_037149264.1\|5395923_5396343_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376540
NZ_CP049748.1\|WP_032401518.1\|5396654_5397230_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP049748.1\|WP_094691067.1\|5382482_5383082_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_037148966.1\|5397326_5398724_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|365848
NZ_CP049748.1\|WP_037149262.1\|5388871_5389879_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP049748.1\|WP_032380171.1\|5396356_5396632_-\|DUF2277-domain-containing-protein	unknown	unknown	gnl\|CDD\|378364
NZ_CP049748.1\|WP_141215841.1\|5394960_5395632_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236873
NZ_CP049748.1\|WP_080734324.1\|5400043_5402353_+\|bifunctional-diguanylate-cyclase/phosphodiesterase	unknown	unknown	gnl\|CDD\|238923
NZ_CP049748.1\|WP_032401525.1\|5388235_5388814_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377192
NZ_CP049748.1\|WP_032380183.1\|5381292_5381745_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP049748.1\|WP_037149261.1\|5387581_5388130_-\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771

Protein	Function_ID	Function_description	E-value
NZ_CP049748.1\|WP_094738244.1\|5385121_5386966_+\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	1.22763e-13
NZ_CP049748.1\|WP_037148963.1\|5391032_5393579_-\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP049748.1\|WP_037148965.1\|5393779_5394943_+\|flavoprotein	gnl\|CDD\|99784	cd06187, O2ase_reductase_like, The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD/NADH domain and/or discrete) to the oxygenase. Dioxygenases add both atoms of oxygen to the substrate, while mono-oxygenases (aka mixed oxygenases) add one atom to the substrate and one atom to water. In dioxygenases, Class I enzymes are 2 component, containing a reductase with Rieske type [2Fe-2S] redox centers and an oxygenase. Class II are 3 component, having discrete flavin and ferredoxin proteins and an oxygenase. Class III have 2 [2Fe-2S] centers, one fused to the flavin domain and the other separate.	3.90536e-97
NZ_CP049748.1\|WP_037148967.1\|5402349_5402985_+\|5,6-dimethylbenzimidazole-synthase	gnl\|CDD\|380321	cd02145, BluB, 5,6-dimethylbenzimidazole synthase. BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.	2.71858e-66
NZ_CP049748.1\|WP_037148961.1\|5386952_5387561_+\|class-F-sortase	gnl\|CDD\|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	3.36325e-15
NZ_CP049748.1\|WP_155292546.1\|5398724_5399924_-\|DNA-polymerase-IV	gnl\|CDD\|179663	PRK03858, PRK03858, DNA polymerase IV; Validated.	0
NZ_CP049748.1\|WP_037148953.1\|5381712_5382351_-\|hypothetical-protein	gnl\|CDD\|377946	pfam07947, YhhN, YhhN family. The members of this family are similar to the hypothetical protein yhhN expressed by E. coli. Many are annotated as possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues. A human member of this family, formerly known as TMEM86B, is a lysoplasmalogenase that catalyzes the hydrolysis of the vinyl ether bond of lysoplasmalogen. Putative conserved active site residues have been proposed for the YhhN family.	5.99163e-13
NZ_CP049748.1\|WP_032401529.1\|5383620_5384847_+\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.86601e-97
NZ_CP049748.1\|WP_037149264.1\|5395923_5396343_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	3.30299e-05
NZ_CP049748.1\|WP_032401518.1\|5396654_5397230_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.61463e-12
NZ_CP049748.1\|WP_037148966.1\|5397326_5398724_+\|cytochrome-P450	gnl\|CDD\|365848	pfam00067, p450, Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.	4.86428e-79
NZ_CP049748.1\|WP_037149262.1\|5388871_5389879_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	2.25767e-06
NZ_CP049748.1\|WP_032380171.1\|5396356_5396632_-\|DUF2277-domain-containing-protein	gnl\|CDD\|378364	pfam10041, DUF2277, Uncharacterized conserved protein (DUF2277). Members of this family of hypothetical bacterial proteins have no known function.	3.51182e-32
NZ_CP049748.1\|WP_141215841.1\|5394960_5395632_-\|hypothetical-protein	gnl\|CDD\|236873	PRK11186, PRK11186, carboxy terminal-processing peptidase.	0.0015334
NZ_CP049748.1\|WP_080734324.1\|5400043_5402353_+\|bifunctional-diguanylate-cyclase/phosphodiesterase	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	8.57615e-95
NZ_CP049748.1\|WP_032401525.1\|5388235_5388814_-\|hypothetical-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	2.04636e-10
NZ_CP049748.1\|WP_052058227.1\|5383162_5383624_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	6.55896e-09
NZ_CP049748.1\|WP_037149261.1\|5387581_5388130_-\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	9.681e-67

>NZ_CP049748.1|WP_037149262.1|5388871_5389879_-|hypothetical-protein
MWFGLAAIALVGAVALLYIDRSKRDQSGRLRQMWAKAQGYEYRPHDEELVTRFSRAALSKPEFDVALGVVTGVRRGEEFVLFDVEETGTIVAVQRSVGSDVDIDLRPRSTPPPRDGDMELLGSIGPRVVFATDVDIARRVCDQRMAAFTESVPENLQLLWSEKDWTLGSLPLGSSGRDWDAAIDAVARLSGMLHVLPPVRGSAVYGARAGEPGRDRGDPGRPLVKEARPQQAQPQPRVAEPTRSEPRVRPPQAARPQVARPEISRPQEPRPQEPRPQEPRDHEPRPQEPGRRPRPPRPDAAGPQAVRSANPSRSVPRPPASRPIPFDSERRRNQP
>NZ_CP049748.1|WP_032401525.1|5388235_5388814_-|hypothetical-protein
MTVFVVVAIVVVVVLLLVGYVASTVRRLGRYSEQTEQSLRLVDVELERRHQQLVPFIEAADASGLSADAVRQLGGARSWSRAVRDRDLGPSAQAAAENALSAAFHAVLAEADAGRNVLGNWAFQGPAGELAVTERRIAGAVRVYNDTAYRLSQAIGTFPSSIVAKSRSLTAPEPFVETRDVLDEQLSDQVAA
>NZ_CP049748.1|WP_037149261.1|5387581_5388130_-|orotate-phosphoribosyltransferase
MAESAANSDRQELADLVKELAVVHGKVTLSSGKEADYYVDLRRATLHHRAGALIGSLMRDLVSDWDFVSVGGLTMGADPVAMSIMHAQGRPIDAFVVRKAAKAHGMQRQIEGPDIVGKRVLVVEDTTTTGNSPLTAVKALRDAGATVVGVATVVDRATGADEVIAAEGLEYRSLLGLADLDL
>NZ_CP049748.1|WP_037148961.1|5386952_5387561_+|class-F-sortase
MPPRSTRWLWTAILTFVLLVSGCASDEVGIAAPDRSPVQSQISVAAPAGDVAPAQPEYIELRSSDGTTYLSSPIHPDPLYRGGESGQVLNPVDELPAWWAESGMPGTSTEQTVVVAGHNYSKRDAPFKALRVVTPGDTVVLRTASGTLEYAVESVGPLPKGSLLADNELRRSVPGRLILANCDVQGGEPTDDNFVVVAQLVR
>NZ_CP049748.1|WP_094738244.1|5385121_5386966_+|hypothetical-protein
MSQKSIARSKKARLAAAGAAMALSLSIAAPGIASAQTPTPESPAVEQPATEGSTESGAPTAEEGATVDGSGTASVEGQIQAPAPAVTPEDAAAAAAAAAAVPAPAAPSDIRPMPQITGGVVFNDDGTATVNVDIIPQLSDAEKQAITDAEAASKLAAEASAAAQVRLDTAKAADTAASSDATKAEVAAAEADVKAKAAAAEAKKAGVASQAASAAVTAAKNDAAELKTTADEAQAAADQAAADAAAAEKIAADLEAAAVSGDPEATAAAEAARADATAKAELAATAKAEADASNKAVEDSVAALQESFKNFNLAKVIAATRAAAATAAKSLALHVEAQTAAAVAAMAEQNAKNLEAAAEAAAGEDTASEQAAAEARDKADAAKTDSDAKAAAAAAAQAALDEAPSDADIAALQAEADKAAQALTDANAAAAAADADLQTKTDAAAAAKVKATDAATALTAAQAEATTAKANSDAKAKAEADLKAEAAELAASGPKFSWTINLGSVVREDVPVTEVDENTVVVDKTGVSLVGVKNEDGSFTVADYFTTDENGVVSVAGDLPPVDLALGDSSNEASGGSDSSSNTPVILAGVGVVVVAAAGGAFYLRRRNSSDATS
>NZ_CP049748.1|WP_032401529.1|5383620_5384847_+|MFS-transporter
MTTSTSPDSLLKQPRAVWAVAFASVIAFMGIGLVDPILKPIGEQLDASPSQVSLLFTSYMLVTGVAMLITGVVSSRFGPKRTLLVGLAIIVVFAALAGTSGSVGEIIGFRAGWGLGNALFIATALSTIVGAASGGVARAIILYEAALGIGIATGPLVGGVLGGFSWRGPFFGVAALMAVAFILLIVMLPDTPKPAHTTSILDPFRALRHRGLLTVGITALLYNYGFFTLLAYTPFPLDMGTYSIGFIFFGWGLCLAVASVFIAPKLQRAFGTLNMMMLALLLFAVDLAVMAMFTENKTVLIVGTVVAGLFLGVNNTLITETVMISAPVERSTASAAYSFVRFTGGAAAPYLAGKLGESNMHVPFWVGAACTALAIVVLATGRKVLAHVDDHEPAPHSIDEARAVTVGD
>NZ_CP049748.1|WP_052058227.1|5383162_5383624_+|winged-helix-turn-helix-transcriptional-regulator
MSHSDEDIRDLLSQLVTSSSRFVRLAARFGSDEWPRAWMRALSLLEEYQPLRISTFAELDRCSQPSATALLAKLSNADLVTRRSDPDDSRAVLVEMTEAGHRWLADGRRHLVDGLVPYLSDLDPEQIQKLTDGLGELRSILEPVDHGMRGTLS
>NZ_CP049748.1|WP_094691067.1|5382482_5383082_+|hypothetical-protein
MRRKLTGQARSAHTDFSGYPNPLLRDCDVRQARIKHWVTALLIVMIPVSLWLGLSAHADQQQRLENQSSSIHQVTATTTATAETTSVASTEFGSSGAAAATAVDSRWVYRGVEHTGRVSVDTGSPAGTTTEIWVDNSGNLSLRPLTSADVVAASIFNAVGSWVLVAVVLIGFYHVMCFRYDGRRNAEWDRDIADLLSRH
>NZ_CP049748.1|WP_037148953.1|5381712_5382351_-|hypothetical-protein
MTVDRVRRARGAALVAGAVTVVGAWTGSTPLQRIAKPLIVPALATGLDPARDRVLLAGLAAATAGDVLLIDPDDDSALEWGARAFAVMQGSYACLLLRRGARPAPIDAIPRYAGWAAAAVLLARRQPAVASTLSAYGAVLATTSTLSAVSPARGGDRRLMIGGALFTASDALIVFRRLFLSEERHRRTAEAIILSTYVAAQVLLVEALRSGQ
>NZ_CP049748.1|WP_032380183.1|5381292_5381745_+|hypothetical-protein
MNNTRIVRAVVVVTVVYAVVLAIWIGWLNPRTPPGTLPYQLAALVAGFGAALGLAMMIAGRPTREQKELIEHGVEGWATVDAIRRIDHDTAELDLEFTVPGSSSYFGKIVYDIPESDTARFEPGTVIAVRVDPAHRERVLLLPRPQSLDE
>NZ_CP049748.1|WP_037148963.1|5391032_5393579_-|ATP-dependent-chaperone-ClpB
MDSFTPTTKSQAALSAALQAASAAGNPDIRPAHLLVALLDQTDGIATPLLKAVGVDPATVRREAQNLVDRLPSASGSTTTPQLGRETLAAITAAQHLATELDDEFVSTEHLMVGLATGDSDVAKLLTGHGAGPNDLRDAFQAVRGSARVTSADPENTYQALEKYSTDLTALAREGKLDPVIGRDTEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRVVAGDVPESLRGKTVVSLDLGSMVAGAKFRGEFEERLKAVLDDIKNSAGQVITFIDELHTIVGAGATGESAMDAGNMIKPMLARGELRLVGATTLEEYRKYIEKDAALERRFQQVYVGEPSVEDTVGILRGLKERYEVHHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAASRLRMEIDSRPVEIDEVERAVRRLEIEEMALAKETDDASKARLDKLRQELADLQEKLAGLSTRWQNEKNAIDSVRVLKEELENLRGESDRAERDGDLGKAAELRYGRIPTLEKELAVKTEASPAQGDVMLKEEVGPDDVADVVAAWTGIPAGRMLEGETAKLLRMEDELGKRVVGQKDAVQAVSDAVRRARAGVADPNRPTGSFLFLGPTGVGKTELAKALAEFLFDDERAMVRIDMSEYSEKHAVARLVGAPPGYVGYEAGGQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLAVLDEGRLTDGQGRTVDFRNTILILTSNLGAGGTKEQVLDAVRRSFKPEFVNRLDDVVVFDALSEDQLESIVDIQLGFLTKRLAARRLTLEVSSPAKMWLAARGYDPLYGARPLRRLIQQAIGDQLAKLLLAGDVHDGDVVSVNASPDGERLILG
>NZ_CP049748.1|WP_037148965.1|5393779_5394943_+|flavoprotein
MLVARTISLVRTGFKSVVASPDGPARLSRSFYAHLFAEYPDFRSLFPASMDSLREHFVLALGYVFEHLDDTDRVEPFLEQLGRDHRKHGISGAHFRAGSSALISAFRTFAGTEMWTDEVETAWHDALTVVSNAMAAAADNDELPPYWSATVVEHQRLLDDLAVVRLKTDGEIPYFPGQYVSVQIPQRPKLWRYLSPAIPSNPYGEIEFHVRRVSGGWVSPAMVTETRVGDRWSISPPLGGMHVDRAIHEDVLMIAGGTGLAPLRAQVMEMAQRSNNPRVHLFVSGTYPCDLYDLDTLWQLSLSNPWLTVVPVTEELEDPWWYSGPARELPWGMHHRLHGAVGKVVTRFGSWADRQIQICGSPSMVRTTLYALRKVGTPMEHVQHDPF
>NZ_CP049748.1|WP_141215841.1|5394960_5395632_-|hypothetical-protein
MADRRRRTFDSRDGDAEVVEPLLRAVLSYAPRDESPPPHPSEGITLRAENGSGCIRLELAIAGDLGTGIPGPFGSRFYECGSYEVIVPQRDPHDGALLMIHLLAPQAPHRFEFTTSMPPLWSLRLEHDGSVSVLDEVGIAVIFIGRPWAFDGDLQPVHVHYTIENGLLVQNVGVTPDTGYPILIDPDPDAIITGDGRLVTEAWTPRLVVGGVVEDVPPKSLSS
>NZ_CP049748.1|WP_037149264.1|5395923_5396343_+|helix-turn-helix-transcriptional-regulator
MSADFAARLNHLFSTIHPAGRKPHTNAEVADALALRGHQISKPYISQLRSGQRANPSADTVTALAAFFKVKPDYFFDNIYAAKVDHDLELLGRLQGYGLRRLAARAFDLSEESQNLLSSMAEKLRVSEGLPAVPPDSTR
>NZ_CP049748.1|WP_032380171.1|5396356_5396632_-|DUF2277-domain-containing-protein
MCRNITTLRGLEPHATDEEVEAAARQYVRKISGVQKTSDATRDAFELAVAEVTATTHRLLDALPDRRQPPPTVPPLRRPEVQARIAAKAGA
>NZ_CP049748.1|WP_032401518.1|5396654_5397230_-|TetR/AcrR-family-transcriptional-regulator
MTTPRKRMTPAQRRAQLLEIGSALFAERPYEDVWIEEVADLAGVSRGLMYHYFPSKREFFVEIVRTESERNLDVTAPDTSLPVLEQVAAGLDAYIAYSDEHAHGLRAVNRGALLGDHRINDILTREFAVQQERILAALPPAFADDEMVRTALRGWIAFVRAVCLDWVERRTLDREQVRELCLRALSGLLEV
>NZ_CP049748.1|WP_037148966.1|5397326_5398724_+|cytochrome-P450
MSTQFAVRNGSLPHPPYRLPVLGDVVGVDPRTPIQDSTVLAGRLGPMFEREILGRRFVFASGADVVGELCDEKRFEKFLPPGVENLRDIGADGLFTAYNHEPNWQRAHDLLRPAFTAGAMRGYHEIMVDVADDLIEHWEGRSRSGADTDVSSDMTKLTLETIGRTGFSYSFGSFARAEPHPFVAAMVGALTYNQRRSLLSIPAFAKPLFAKSDRRYAHNKQYLADVLADVVRTRRRSNEDFSDLLQIMMDAAKDADNPNALSEANIGYQILTFLIAGHETTSGALSFALYYLANHPEVFERARAEVDEVWGTGKPQFGQVPKLRYVRRVLDESLRLWPTVPAFGRGARADTVIGDDYRMAAGDWAVVLVTALHRDPVWGDRPSDFDPDNFLPDRIKARPAHVYKPFGTGERACIGRQFAIHEAVLVLGTILQRFDLQADPSYRLKVQERLTMMPEGFRVRLTVRT
>NZ_CP049748.1|WP_155292546.1|5398724_5399924_-|DNA-polymerase-IV
MASIMHADLDSFYASVEQRDDPRLRGKPVIVGGGVVLAASYEAKAFGVRTAMSGGQARAVCPQAIVVPPRMEAYSQASKDVFDVFHDTTPLVEGISIDEAFLDVGGLQKIAGSATEIGQRLRQEVAEQVGLPITVGIATTKFLAKVASAFAKPDGLLLVPPGGELEFLHPLNIERLWGVGKVTAEKLHVLDIRTVGDIAAYGERSLASVLGKGAGAHLYALAMGRDPRRVQPGKSRSSIGAQRALGRGRHDAAEVEASLIGLVDRVTHRMRAAERTGRTVMLRLRFADFTRATRSHTLDRATADTRDILDAALELLHDAAPLIAEKGITLVGVTVSSIDKGGAEQLELQFDAPQVRKPPEASALDRALDGVHKKFGSTSLTRGVLLGRDPGISVPLLPD
>NZ_CP049748.1|WP_080734324.1|5400043_5402353_+|bifunctional-diguanylate-cyclase/phosphodiesterase
MSSDRRERLERIVTAWWRWYAALGVLGCVAYFAVPSIAAAQSIFVLVGASAVAATVIGTRMHRPTNRTAWLTIALGTGLWVVGDIVFEWIDVTRGSVPEPSLADAFYLVAYPIYGFGLFLLVRHKWRASERGHVANSAIVMVAFGLLTWVFAVQPTLGNDGISGTAGLVDVAYPAMDIFLLGLLAHFVGSRQWRTLSYRLLTTAVLLLVVTDIVNNFSIVSEPSSERSLIDVGWTMSYVLIGVAALHPSMRRITSPNIEPEAHLMASFTTPTVVVLTAATLTAPTVMFIEVIRDEPIAQWGWAVLLCASALVILVIYRITDLLRLLHTQTVRLRAAADTDHLTGLANLRALEHRIWQNAGDTTLLTVDIDRFKEINDTFGRGLGDQVLVAVADRLRGVGDDSIMLARLAGDEFALCGTADSMDPTALAHEIQRRFAAPFDVGTMTLLIEASVGVAFSLTIAEGEDEDTPDRLVQRADLAVQAAKATQSRVAFYDRSMDRDTSAQLIMLGELTTALESDQLELLYQPQVDLESMTVVGVEALLRWHHPNGMLLAPSAFLPTAERTGLIRPLTSYVLTRALAQRSLWAMDGLDLQMAVNISTRNLFDDTLIAQVRTALREFHCPAERLTLEVTETSAMTDPVGATEMLSILHAMGVQVAIDDYGTGYSSLAYIERLPVQELKMDRTFVGGMAHDPAHAAIVRSTVELARTLGLSVTAEGVEDEMTMTALRELRCGRAQGYHLGRPTSSDLLPALVAELNTRLKTVTGERIP
>NZ_CP049748.1|WP_037148967.1|5402349_5402985_+|5,6-dimethylbenzimidazole-synthase
MTEAALSVYAAIRSRRDVRAEFDGTVVDDDTLRRILGAAHQAPSVGNTQPWDFVVVRKPDTLSAFAAHVAGCRQDFADKLDAERRKTFDPIRIEGIETSGTGVVVTYDPNRGGRHVLGRDTVDDTGLFSAVLAIENLWLAAIAENVGVGWVSFYDEAYLTELLDIPAPVRPIAWLCVGPVESFQEVPDLERFGWRSRRPLDDAMHFEQYRR

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP049748_5	5.1\|3865855\|40\|NZ_CP049748\|CRISPRCasFinder	3865855-3865894	40	NZ_LR134456	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence	110251-110290	9	0.775

1. spacer 5.1|3865855|40|NZ_CP049748|CRISPRCasFinder matches to NZ_LR134456 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 14, complete sequence) position: , mismatch: 9, identity: 0.775

actcgccgccgaccgcggcagcgacctggccgacgaggcc-	CRISPR spacer
gctcgccgccgaccgcggcatcgatctgg-cggcgttcctc	Protospacer
.******************* ***.**** **.**   *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1506787 : 1563566

Mycobacterium_phage(30.0%)

integrase,transposase

attL 1546532:1546549|attR 1568461:1568478

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_037146834.1\|1506787_1507954_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_094684325.1\|1508046_1509066_+	recombinase	NA	NA	NA	NA
WP_037146831.1\|1509201_1510227_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_037146828.1\|1510336_1510657_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_037146827.1\|1510681_1512070_+	cytochrome P450	NA	NA	NA	NA
WP_037146826.1\|1512066_1513275_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_037147416.1\|1513344_1514085_+	transglutaminase domain-containing protein	NA	NA	NA	NA
WP_037146825.1\|1514479_1515316_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_037146824.1\|1515362_1516427_+	BtrH N-terminal domain-containing protein	NA	NA	NA	NA
WP_008720413.1\|1516872_1517427_+	PaaI family thioesterase	NA	NA	NA	NA
WP_080734183.1\|1517443_1518937_-	MFS transporter	NA	NA	NA	NA
WP_037147412.1\|1519123_1519828_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_037146818.1\|1520075_1520630_+	recombinase family protein	A0A0F7LA37	Escherichia_phage	2.8e-42	51.4
WP_037146812.1\|1520644_1521577_-	GIY-YIG nuclease family protein	NA	NA	NA	NA
WP_037147410.1\|1521576_1526502_-	DEAD/DEAH box helicase	A0A2H4UTW8	Bodo_saltans_virus	3.8e-34	24.7
WP_080734182.1\|1526718_1527387_-	hypothetical protein	A0A2K9V3H4	Faecalibacterium_phage	4.8e-33	40.1
WP_052057730.1\|1527468_1528110_-	hypothetical protein	NA	NA	NA	NA
WP_052057729.1\|1528273_1528783_-	hypothetical protein	NA	NA	NA	NA
WP_037146810.1\|1529337_1529574_+	hypothetical protein	S5YMP4	Mycobacterium_phage	1.1e-08	47.7
WP_037146805.1\|1529622_1529922_+	hypothetical protein	NA	NA	NA	NA
WP_037146804.1\|1529978_1530308_+	hypothetical protein	NA	NA	NA	NA
WP_155292480.1\|1530304_1530478_+	hypothetical protein	NA	NA	NA	NA
WP_155292655.1\|1530778_1531957_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	9.4e-40	33.8
WP_052058739.1\|1532348_1532957_+	hypothetical protein	NA	NA	NA	NA
WP_037154365.1\|1533155_1533461_+	hypothetical protein	NA	NA	NA	NA
WP_114332301.1\|1533766_1534987_-	cold shock domain-containing protein	NA	NA	NA	NA
WP_094684224.1\|1535193_1535466_-	hypothetical protein	NA	NA	NA	NA
WP_155292690.1\|1535804_1536068_-	hypothetical protein	NA	NA	NA	NA
WP_037154353.1\|1536703_1536931_+	hypothetical protein	NA	NA	NA	NA
WP_155289412.1\|1536906_1537506_-	hypothetical protein	NA	NA	NA	NA
WP_032364201.1\|1538303_1538654_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_080732888.1\|1538667_1539666_-\|integrase	tyrosine-type recombinase/integrase	S5W9T9	Leptospira_phage	1.2e-11	23.5
WP_032364250.1\|1539993_1540224_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_032364202.1\|1540257_1542426_+	heavy metal translocating P-type ATPase	A0A218MNH6	uncultured_virus	1.4e-65	32.7
WP_032364203.1\|1542530_1543157_-	DUF305 domain-containing protein	NA	NA	NA	NA
WP_032364204.1\|1543242_1543662_-	hypothetical protein	NA	NA	NA	NA
WP_141216797.1\|1543713_1544931_-	MFS transporter	NA	NA	NA	NA
WP_032364206.1\|1544994_1545579_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_080732887.1\|1545754_1547059_+	MFS transporter	A0A0M3UL24	Mycobacterium_phage	7.2e-49	37.6
1546532:1546549	attL	NA	NA	NA	NA
WP_052053408.1\|1547083_1547548_-	VOC family protein	NA	NA	NA	NA
WP_032364207.1\|1547695_1548019_-	hypothetical protein	NA	NA	NA	NA
WP_052058737.1\|1548763_1549939_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_080734543.1\|1549889_1552388_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_037154346.1\|1552398_1553919_-	hypothetical protein	NA	NA	NA	NA
WP_052058735.1\|1554137_1554788_-	hypothetical protein	NA	NA	NA	NA
WP_032401325.1\|1555799_1556036_+	hypothetical protein	S5YMP4	Mycobacterium_phage	1.3e-09	49.2
WP_032401326.1\|1556081_1556381_+	hypothetical protein	NA	NA	NA	NA
WP_032393544.1\|1556455_1556785_+	hypothetical protein	NA	NA	NA	NA
WP_155288773.1\|1556781_1556946_+	hypothetical protein	NA	NA	NA	NA
WP_155292689.1\|1557206_1557371_+	hypothetical protein	NA	NA	NA	NA
WP_080734552.1\|1557382_1557694_-	hypothetical protein	NA	NA	NA	NA
WP_037154337.1\|1558463_1558751_+	hypothetical protein	NA	NA	NA	NA
WP_080734542.1\|1558850_1559453_+	ParB N-terminal domain-containing protein	NA	NA	NA	NA
WP_037154334.1\|1560607_1560793_-	hypothetical protein	NA	NA	NA	NA
WP_037154332.1\|1560931_1561300_-	Lsr2 family protein	A0A160DEV0	Gordonia_phage	1.1e-18	41.0
WP_080734540.1\|1561387_1562317_-	hypothetical protein	NA	NA	NA	NA
WP_094653340.1\|1562627_1563566_+\|integrase	site-specific integrase	NA	NA	NA	NA
1568461:1568478	attR	NA	NA	NA	NA

DBSCAN-SWA_2

3396607 : 3405219

Indivirus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_032403331.1\|3396607_3397789_+	protein translocase subunit SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.0e-22	30.4
WP_032403332.1\|3397815_3399519_+	peptide-binding protein	NA	NA	NA	NA
WP_032403333.1\|3399515_3400055_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	4.2e-19	38.3
WP_032403654.1\|3400273_3402607_+	RelA/SpoT family protein	A0A2I2L310	Orpheovirus	3.0e-13	39.3
WP_052058630.1\|3402674_3403475_-	peptidylprolyl isomerase	A0A1V0SCU1	Indivirus	1.3e-05	30.3
WP_032377781.1\|3403471_3404335_-	peptidylprolyl isomerase	A0A1V0SCU1	Indivirus	5.5e-05	30.8
WP_037153193.1\|3404526_3405219_+	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	3.7e-20	30.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP049748

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection