CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP009755	Curtobacterium sp. MR_MD2014 chromosome, complete genome	10 crisprs	DEDDh,cas3,RT,WYL,csa3	1	4	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP009755_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009755_1

137257-137337

Orphan

Consensus_repeat	Method
CCGAGCACGACGCAGCCGAACACGAGCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009755_1

>merge|NZ_CP009755|1|137257-137337|CRISPRCasFinder
CCGAGCACGAACCAGCCGAGCACGACGCAGCCGAACACGAGCCCCTCGCGCCCGAGCACGAGCCCGTCGCGCCCGAGCACG

>NZ_CP009755|1|1|137257-137337|CRISPRCasFinder
CCGAGCACGAACCAGCCGAGCACGACGCAG	CCGAACACGAGCCCCTCGCGC
CCGAGCACGAGCCCGTCGCGCCCGAGCACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009755.1\|WP_066657594.1\|133370_134381_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381300
NZ_CP009755.1\|WP_066651411.1\|144709_145231_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225937
NZ_CP009755.1\|WP_066657597.1\|143644_144202_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|238269
NZ_CP009755.1\|WP_066657592.1\|131442_132438_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187575
NZ_CP009755.1\|WP_066651406.1\|143282_143672_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NZ_CP009755.1\|WP_066651400.1\|137997_138489_-\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|376376
NZ_CP009755.1\|WP_066651391.1\|127864_128236_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066651387.1\|127006_127837_-\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|376405
NZ_CP009755.1\|WP_066651398.1\|135081_136365_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|366703
NZ_CP009755.1\|WP_144411410.1\|126227_126944_-\|DUF2071-domain-containing-protein	unknown	unknown	gnl\|CDD\|378271
NZ_CP009755.1\|WP_066657599.1\|142494_143286_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NZ_CP009755.1\|WP_066651385.1\|124874_126146_-\|phosphatidylserine-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|378885
NZ_CP009755.1\|WP_144411187.1\|132496_133162_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066651402.1\|138540_139560_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|238950
NZ_CP009755.1\|WP_066651393.1\|129020_129908_+\|N-dimethylarginine-dimethylaminohydrolase	unknown	unknown	gnl\|CDD\|224747
NZ_CP009755.1\|WP_031272831.1\|139569_140121_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP009755.1\|WP_081984531.1\|145240_147004_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225962
NZ_CP009755.1\|WP_066651404.1\|140286_142275_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	unknown	unknown	gnl\|CDD\|273520
NZ_CP009755.1\|WP_066651410.1\|144198_144687_+\|DUF3180-domain-containing-protein	unknown	unknown	gnl\|CDD\|378650
NZ_CP009755.1\|WP_058729711.1\|128347_128785_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439

Protein	Function_ID	Function_description	E-value
NZ_CP009755.1\|WP_066657594.1\|133370_134381_+\|aldo/keto-reductase	gnl\|CDD\|381300	cd19074, Aldo_ket_red_shaker-like, Shaker potassium channel beta subunit family and similar proteins. This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.	8.58795e-165
NZ_CP009755.1\|WP_066651411.1\|144709_145231_+\|PH-domain-containing-protein	gnl\|CDD\|225937	COG3402, COG3402, Uncharacterized conserved protein [Function unknown].	3.93179e-22
NZ_CP009755.1\|WP_066657597.1\|143644_144202_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|238269	cd00483, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.	7.53184e-50
NZ_CP009755.1\|WP_066651402.1\|138540_139560_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	5.23405e-53
NZ_CP009755.1\|WP_066651400.1\|137997_138489_-\|inorganic-diphosphatase	gnl\|CDD\|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	1.47128e-82
NZ_CP009755.1\|WP_144411410.1\|126227_126944_-\|DUF2071-domain-containing-protein	gnl\|CDD\|378271	pfam09844, DUF2071, Uncharacterized conserved protein (COG2071). This conserved protein (similar to YgjF), found in various prokaryotes, has no known function.	6.12027e-65
NZ_CP009755.1\|WP_066651387.1\|127006_127837_-\|nitroreductase-family-protein	gnl\|CDD\|376405	pfam00881, Nitroreductase, Nitroreductase family. The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	1.62906e-23
NZ_CP009755.1\|WP_066651398.1\|135081_136365_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	9.12108e-38
NZ_CP009755.1\|WP_066651404.1\|140286_142275_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP009755.1\|WP_066657599.1\|142494_143286_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	1.45281e-104
NZ_CP009755.1\|WP_066651385.1\|124874_126146_-\|phosphatidylserine-decarboxylase-family-protein	gnl\|CDD\|378885	pfam12588, PSDC, Phophatidylserine decarboxylase. This domain family is found in bacteria and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam02666. Phosphatidylserine decarboxylase (PSD) is an important enzyme in the synthesis of phosphatidylethanolamine in both prokaryotes and eukaryotes.	6.80403e-48
NZ_CP009755.1\|WP_066651406.1\|143282_143672_+\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	1.80501e-40
NZ_CP009755.1\|WP_081984531.1\|145240_147004_+\|PH-domain-containing-protein	gnl\|CDD\|225962	COG3428, COG3428, Predicted membrane protein [Function unknown].	6.56195e-30
NZ_CP009755.1\|WP_066651393.1\|129020_129908_+\|N-dimethylarginine-dimethylaminohydrolase	gnl\|CDD\|224747	COG1834, COG1834, N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism].	2.2978e-71
NZ_CP009755.1\|WP_066657592.1\|131442_132438_-\|SDR-family-oxidoreductase	gnl\|CDD\|187575	cd05265, SDR_a1, atypical (a) SDRs, subgroup 1. Atypical SDRs in this subgroup are poorly defined and have been identified putatively as isoflavones reductase, sugar dehydratase, mRNA binding protein etc. Atypical SDRs are distinct from classical SDRs. Members of this subgroup retain the canonical active site triad (though not the upstream Asn found in most SDRs) but have an unusual putative glycine-rich NAD(P)-binding motif, GGXXXXG, in the usual location. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.50671e-84
NZ_CP009755.1\|WP_031272831.1\|139569_140121_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	5.69781e-84
NZ_CP009755.1\|WP_066651410.1\|144198_144687_+\|DUF3180-domain-containing-protein	gnl\|CDD\|378650	pfam11377, DUF3180, Protein of unknown function (DUF3180). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	1.07767e-19
NZ_CP009755.1\|WP_058729711.1\|128347_128785_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.39913e-25

>NZ_CP009755.1|WP_066651398.1|135081_136365_+|peptidoglycan-DD-metalloendopeptidase-family-protein
MSPAPHRIPRPRSRRRVIAAAVAVVLSAGALAAVGPVSAASAAGYPSWSDVEQAKASKDAQQAKVTEIKALLQDLTAKASAAQQESEAAGTAYQTAQTKYDAATLEQQTLQHQADDADRTAKRSEEQAGQLAAQLGRASANDVTTDILTHPSDSGDLLYELGAMSKLTEQADGIYSQASQDRGVAQGLADRAEQAKEALGTLADAAQAKMQAAQDAADRAQTAVDAQADNKARLEAQLTLLTTNAKDVEAEYDKGVAAEKAREAARAAAAAKAAEQAAATGQGGSGGGAPNSSGWVRPAGGYQTSPYGYRVDPYTHYRALHAGVDLAPACYAPIYAAHAGTVTFAANGGGYGNEVVLDNGGGISTAYGHIVDGGILVSVGQHVEAGQQIAKIGSTGWSTGCHLHFETRVNGSAVDPVPFMAARGISV
>NZ_CP009755.1|WP_066657594.1|133370_134381_+|aldo/keto-reductase
MEYRYLGNSGLKVSEITYGNWLTHASQVENDAAIACVRAALDVGISTFDTADVYANTGAETVLGEALKGERRQSLEIATKVFGPTGPKGHNDTGLSRKHILESIDGSLERLQTDYVDLYQAHRFDHETPLEETMQAFADVVRQGKVLYVGVSEWTADQLRAGAELAKDLGFQLISNQPQYSALWRVIEGEVVPASKELGISQIVWSPIAQGVLTGKYQPGQPLPEGSRATDDKGGAKMIERFMNDETLSAVQELKPIADELSLSMAQLAVAWVLQNENVASAIIGASRPEQVHDNAGAAGVQIPAELMSRIDDALGSVVERDPAKTNDSSPKTREA
>NZ_CP009755.1|WP_144411187.1|132496_133162_-|hypothetical-protein
MEGRQVTRDDALVEVLTRERLASYERSAGRVAGALRLYEWNMRAAAAVTELTGVVEVVARNAMDTELRRWARSRRREATWFDVAPLDGPGRRDLAKARARATRGGRRPEVHGRVLAELSFGFWRYLVESRYLTSLWTPALHRAFPCGPADVLTRQRQVRARMQQLHFVRNRAAHHEPIHQRDLHRDLDDALELLGWIHPAAAEWAADVTSLSAVLDARPSG
>NZ_CP009755.1|WP_066657592.1|131442_132438_-|SDR-family-oxidoreductase
MSGPSVLFIGGSGIISAACVREAVEQGYDVTVLNRGATDKRPIPDAVTRLQADVSDRTALEAAIGDQHWDVVIDFVAFTPDQVQRDIEVFTGRTNQYVFISSASAYQTPATHLPITESTPLKNPFWQYSRDKIACEDLLTKAYREDDFPMTIIRPSHTYDETLVPFSGGWTVLGRMRAGKPIVVTGDGSSLWTITHARDFAVGFVGLLDRAEAIGEAFHITGDEAPTWDRIAHELAAAAGVEDLQLVHVPADAIDALDADWGASLLGDKANTSVFDNTKVQTLVPEFAQTTSIRQGAREIVAWFDADPSRQVTDEHLDGLMDQLVERWQVR
>NZ_CP009755.1|WP_066651393.1|129020_129908_+|N-dimethylarginine-dimethylaminohydrolase
MSNTATEPQAAPARVATKRTILMCKPTHYTVSYRINPWMHPEEPTDTSKAVEQWQSLVDVYEQLGFDISYIEPIEGLPDMVYAANGGFVLDGVAYGAKFQYPERQPEGPAYMDWFRSAGLTVAEPEETNEGEGDFLLIGDTIFAGTGFRSDSTSHEELARIYGREVVTLKLINPSFYHLDTAIAVLDPEPDATGRSNIAYLESAFDEPSLAILRERFSDAVIATEEDAAILGLNSYSDGYNVVIASRATTFAEQLREKGYNPIGVDLSELLLGGGGVKCCTLDLHPVGTGTSVAR
>NZ_CP009755.1|WP_058729711.1|128347_128785_-|Lrp/AsnC-family-transcriptional-regulator
MDTLDHRILDQLRENARAGYGDIGSVVGLSASAVKRRVDRLVADGVIQGFTIKVDPAVEDRGTEAWVELYCRGTVSPDELRTLLDTVPEVVDAGTVTGSADAVVHMRSRDLPALELALDRVRLAPQVDHTRSAIVLSKLVSRESA
>NZ_CP009755.1|WP_066651391.1|127864_128236_-|hypothetical-protein
MGIGRTAGRRGATPTRPPAARRLVAAAAAAYVANCLWGTAVAVRVIRTEKLRVVHHGLFVVTATLTGVAATTPAWTRDRSALFLLPALVPLALAPRTNPRSGAHWRVAVAAAPSYLGALLARR
>NZ_CP009755.1|WP_066651387.1|127006_127837_-|nitroreductase-family-protein
MELFEAIRRRRTTNGAFLPDPVSEEHQRLLMELAGRAPSQLNSQPWRFVIVEERDTIDRIADISGRSMTQTMAEGSFFTRYRPYFRFSQAEMDERRDGMLFDKLPGPLKPFTKQVFTKRGQLLMNTLRVPQTLGEENRKLVAGSPLLLGVMLDRDEYRKEARNAFYSVFSMGAAMENVWLATTELGLGIQFVSFPMEVEEAWAEVERLLAVPPELELMAVYRIGYLPPERRRPAIDWVSNERKRPSQYVFRGTCATPQQGWDDAPDAARATDGTVS
>NZ_CP009755.1|WP_144411410.1|126227_126944_-|DUF2071-domain-containing-protein
MRGTPWISQDWLDVVFVHWRVDVSAVAPLLPAGAHPDTMAPDGTDDGATTWVGLIGFRFTDTRFPPLGGLGRASSVGDFVEVNVRVYTCDDQGRRGVAFLSLDAGKLLPTIGARVATGLPYWWAHAAIRKTDGRVGYAMRRHGTHLRSTFDVRVGDAVDEPTPLETFLTARWGMHVRRVGATRYWPNEHESWPLHRASLVSLRDDLVAAAGLPFGLSGLEPDSVLYSPGVTTRFGRGR
>NZ_CP009755.1|WP_066651385.1|124874_126146_-|phosphatidylserine-decarboxylase-family-protein
MTGASQQQDVRRRAGWLPQDQSGLEAWLRGRRERHQERDPDRALHPAVSALRDLVEGDPVLRMHAHQMIEQVPAGREYQDRHLESFGELLELVDEVITTAPEYSDEQMVMTPLDGVLDWTKATPAGFAFYRDPRVNDALRTILQGWCDFLSSDKSLEVLVDAPSGWCSDAARRAVGMDRFEHDADAEHWGFGSWNDFFTRRFRDGERPVAAPDDDAVVVSPCEATPYRIASRVHRLDAFWAKAEPYSVEELLAGDETADLFVDGTVWQAFLSALEYHRWHSPVAGTVLRAWVEPGTYYSEASSQGTDAAEPQLSQGYLAHVATRAIVLIDADDPAIGMIAVVFIGMSDVSSCVIGEGISDGAHVGKGDELGYFQFGGSSVCVLFGPDVVESFSLGALPQAPEEESAVLPVRSHLATALRRSSD
>NZ_CP009755.1|WP_066651400.1|137997_138489_-|inorganic-diphosphatase
MTAYDVVVEIPKGSRNKYEVDHETGRVYLDRVLFTSFVYPTDYGFFENTLADDGDPVDALLLLEYPVFPGVGVKVRPVGVFKMSDEAGNDAKVLVVPAKDPRWQHIQDISDVDEQTKAEIAHFFERYKDLEPNKWVKADGWGDAAEAEAIVQAGQAAYVPAGH
>NZ_CP009755.1|WP_066651402.1|138540_139560_+|tRNA-lysidine(34)-synthetase-TilS
MNTPRPRLDPAVAATRLAVRTLLAQARDEGLLHRGDLVTVALSGGADSLALAAATAFEAPKQDLRAGAVVVDHALQAGSEAVASRASRTAASVGLDPVTVRRVAVGTDGGPEGAAREARHAAVAEVAADTGSPLVLFGHTLDDQAETVLLGLLRGSGPDALSGMPPLARRATGPAYGRPLLGVRRHTTRQAAVAAGLVPWDDPQNDDPAYARVRVRSTLMPALERELGAGVPEALARTAEQLREDAAALDHFAEEMAEDLAEHSEAGISLSVPELLANPPALRQRLVRLAVEGEFGVTLSRTQTLEVCRLVTDWRGQGPVDLPGVRASREGERIAFAAR
>NZ_CP009755.1|WP_031272831.1|139569_140121_+|hypoxanthine-phosphoribosyltransferase
MELSDVQADLSEVLFTPEQIDEKLAELAAVVDRDYAGKDPLLVGVLKGAVMVMADFSRHLKMQARMDWMAVSSYGSGTKSSGVVRILKDLDTDLHGRDVIIVEDIIDSGLTLSWLKQNLESRGAASVEIVALLRKPEAAKVEVDVKYAGFEIPDAFVVGYGLDFDERYRNLRGIGVLAPHVYS
>NZ_CP009755.1|WP_066651404.1|140286_142275_+|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein
MNFKRIFRGPYLYVLIALVGIFIGWSVIAQSGTQQIDTQKGLEQLADGKVSSVVVNSTEQRVDLTLKDGNAKEQFYYSTPRGEEVVSAVNDANLPDGYNDVVNQGNWFLSLLGIILPFLIIGALFWFLLSSAQGGGSKVMQFGKSRAKMNNKENPQVTFADVAGSDEAIEELHEIKEFLQEPAKFQAVGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKQNAPAIVFIDEIDAVGRHRGAGIGGGNDEREQTLNQLLVEMDGFDGKTNVILIAATNRPDVLDPALLRPGRFDRQIGVDAPSLQGRKQILEVHAKGKPLAASVDLELLARKTPGFTGADLANVLNEAALLTARSNAQLIDNRALDEAVDRVMAGPQRRTRIMSDQEKLITAYHEGGHALAAAAMRHTDPVTKITILPRGRALGYTMVLPLEDKYSVTRNELLDQLTYAMGGRVAEEIVFHDPTTGASNDIEKATSTARKMVTEYGMSRAVGSVKLGSGSSEPFVGREMGGSSGRDYSENIAETVDAETRALLEAAHDEAYQVLNDNRDILDRLAGELLDKETLDAPELVEIFKDVRKLPERPQWLSSDRRPVSNLPAIEFPGKAASTAAEQGDTESSSKPRRRPFGNPGIAPA
>NZ_CP009755.1|WP_066657599.1|142494_143286_+|dihydropteroate-synthase
MGILNVTPDSFSDGGLHLAVDAAIAHARDLVRAGADLVDVGGESTRPGAERVPVAVEQQRVLPVVRQLVSEGIAVSVDTMNASTAERAVEAGAAIVNDVSGGLADDDMARVVRDTGAGFVVMHWRGHSDRMHRNAEYAHAVEEVRREVELRVAELIVLGIREEQVVIDPGLGFAKHGAQNWEILAGYERFASIGLPVLVAASRKRFLDGVGSAAGAPPRDRDLATAAISLLAAERGAWGVRVHDPAPTRAVLDVWDAWRAARS
>NZ_CP009755.1|WP_066651406.1|143282_143672_+|dihydroneopterin-aldolase
MRDTIRLTGVRARGNHGVFDHERADGQDFVVDVAVEVDARVSSGSDDLADTVHYGVVAEQVVAEIEGGPVDLIETLAERIASAVLTHRAALAVEVTVHKPQAPITVPFSDVSITIRRTRGGSVSHEEEE
>NZ_CP009755.1|WP_066657597.1|143644_144202_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MGVPRGRRVSRAVIALGANLGDRGSTLRAAAQAIAAVPGIRPVASSHEVESVALTLDGLDDSKPRYRNGVVVVETDLAPHDLLDALHRIEDDHGRTREVRWGDRTLDLDVIAVDDLLIDSGTLTVPHPRAGERAFVLAPWLDADPDAVLPGAGRVADLLDGLGDDTERVDEPRLFDAVPGSGSAA
>NZ_CP009755.1|WP_066651410.1|144198_144687_+|DUF3180-domain-containing-protein
MNPTRASTLISVAVVAVVAGFALDAVLASRQAPTLLLSTPLGVTLALIGVAVVAMARPVRRHARDGATRQHPVDPLYATRVVVLAKASSLAGALFGAFAAGLLLYLLTRSALPPLGSVLPNAVAVGGGLVLVVCALVAERMCMAPPPGDDDDDLPRGGTTAN
>NZ_CP009755.1|WP_066651411.1|144709_145231_+|PH-domain-containing-protein
MPLERLDEPGLGLTGTTWTRVSPKLVWTELVSTIVVGVVVTAGCVLFAVLFGGFGGAAGTVWSCVAIVVALVALVTAVLTPRRVRAIGYALRDDDLVLRRGLMWQRFTAVPYGRMQLVDVNRGPLDRILGLSELKFVTAAAATNVRIPGIPAADADELRDRLVELAESRRAGL
>NZ_CP009755.1|WP_081984531.1|145240_147004_+|PH-domain-containing-protein
MTFRPGPPPPAPPRRGDAAAAAPLTDGEWHRLHPLTPLLKGGIFLIVILGYVLNNLRDQLLEFFVPGGAPQDDGDPVRYVWEHGAVGWVLLGVVVLLLVLLGLFTVSWRMHEFRVTGDVVEVRSGVLFRSHRKARLDRIQGINISRPVVPRIFGTAKLEIAQAGNDANVQLAYLGARAADDLRQRILVLASGAQDDEETARRDSNGVLQDRVGELFSPELDPAAVHATRIVKVHPGRLIASMLLSGTTVFFVVVIVAMIVSIAITGEYGILIGLFPVVIGAGGYTVRKFSRSLQYTIAETRDGIRIGFGLVSTSNETLPPGRIHAVSVAQPLLWRPFGWWDVRINRATNAGNGASNNQQVSSIVLPVGRAEDVREVLDIILPGLVGTAVAGPTASREELREGSSEAVNVVDDSLTTTGDRGGFVHSPRRGAWLRPFSFRRNGYRFVQGAVLLRLGAVWRSLVIVPLPRVQSVKVEQGPLERVLRLATAHVHTVSGPVSARIGALDALDAQRLWSESAHRAVEAAAVDTTHRWRAREARRTPATHAPDGQVVATAADAAPTGTWRADGGTQAVPPGRWSDVPPPGALR

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Crispr_ID: NZ_CP009755_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009755_2

494854-494945

Orphan

Consensus_repeat	Method
GCACGGACGACGGCGCTGCCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009755_2

>merge|NZ_CP009755|2|494854-494945|CRISPRCasFinder
GCACGGACGACGGCGCTGCCGGCGGTGCAGGACGACGACCGGGGCGACCGCGAACACCGCGACGACGATGCACGGACGACGGCGGTGCCGGC

>NZ_CP009755|2|2|494854-494945|CRISPRCasFinder
GCACGGACGACGGCGCTGCCGGC	GGTGCAGGACGACGACCGGGGCGACCGCGAACACCGCGACGACGAT
GCACGGACGACGGCGGTGCCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009755.1\|WP_066652014.1\|485286_485910_+\|phosphoribosylanthranilate-isomerase	unknown	unknown	gnl\|CDD\|238237
NZ_CP009755.1\|WP_066652010.1\|483765_483969_-\|DUF2945-domain-containing-protein	unknown	unknown	gnl\|CDD\|378576
NZ_CP009755.1\|WP_066652016.1\|486001_486760_-\|HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319784
NZ_CP009755.1\|WP_066652018.1\|486870_487464_-\|nitroreductase	unknown	unknown	gnl\|CDD\|380315
NZ_CP009755.1\|WP_081984594.1\|482987_483761_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP009755.1\|WP_066652028.1\|496335_497289_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381307
NZ_CP009755.1\|WP_066652030.1\|497380_498025_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224331
NZ_CP009755.1\|WP_066652042.1\|504897_505794_+\|UbiA-family-prenyltransferase	unknown	unknown	gnl\|CDD\|172161
NZ_CP009755.1\|WP_066652022.1\|491442_493131_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_144411218.1\|503992_504868_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|377115
NZ_CP009755.1\|WP_066652024.1\|493207_493759_+\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NZ_CP009755.1\|WP_066652044.1\|505790_507242_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
NZ_CP009755.1\|WP_066652032.1\|500241_500931_-\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NZ_CP009755.1\|WP_058730132.1\|507261_508059_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_CP009755.1\|WP_066652019.1\|487638_488562_+\|AEC-family-transporter	unknown	unknown	gnl\|CDD\|223751
NZ_CP009755.1\|WP_066657681.1\|498428_499670_+\|sodium:proton-exchanger	unknown	unknown	gnl\|CDD\|223604
NZ_CP009755.1\|WP_066652046.1\|508197_508944_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367243
NZ_CP009755.1\|WP_066652012.1\|484169_485222_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP009755.1\|WP_066652040.1\|500953_501835_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP009755.1\|WP_066652020.1\|488929_489766_-\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197320

Protein	Function_ID	Function_description	E-value
NZ_CP009755.1\|WP_066652014.1\|485286_485910_+\|phosphoribosylanthranilate-isomerase	gnl\|CDD\|238237	cd00405, PRAI, Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric, monofunctional and thermolabile, but in some thermophile organisms PRAI is dimeric for reasons of stability and in others it is fused to other components of the tryptophan biosynthesis pathway to form multifunctional enzymes.	5.93661e-72
NZ_CP009755.1\|WP_066652010.1\|483765_483969_-\|DUF2945-domain-containing-protein	gnl\|CDD\|378576	pfam11160, DUF2945, Protein of unknown function (DUF2945). This family of proteins has no known function.	5.50032e-16
NZ_CP009755.1\|WP_066652016.1\|486001_486760_-\|HAD-IIB-family-hydrolase	gnl\|CDD\|319784	cd02585, HAD_PMM, phosphomannomutase, similar to human PMM1 and PMM2, Saccharomyces Sec53p, and Arabidopsis thaliana PMM. PMM catalyzes the interconversion of mannose-6-phosphate (M6P) to mannose-1-phosphate (M1P); the conversion of M6P to M1P is an essential step in mannose activation and the biosynthesis of glycoconjugates in all eukaryotes. M1P is the substrate for the synthesis of GDP-mannose, which is an intermediate for protein glycosylation, protein sorting and secretion, and maintaining a functional endomembrane system in eukaryotic cells. Proteins in this family contains a conserved phosphorylated motif DxDx(T/V) shared with some other phosphotransferases. This family contains two human homologs, PMM1 and PMM2; PMM2 deficiency causes congenital disorder of glycosylation type I-a, also known as Jaeken syndrome. PMM1 can also act as glucose-1,6-bisphosphatase in the brain after stimulation with inosine monophosphate; PMM2 on the other hand, is insensitive to IMP and demonstrates low glucose-1,6-bisphosphatase activity. Arabidopsis thaliana PMM converted M1P into M6P and glucose-1-phosphate into glucose-6-phosphate, with the latter reaction being less efficient. Arabidopsis thaliana and Nicotiana benthamian PPMs are involved in ascorbic acid biosynthesis. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.76807e-43
NZ_CP009755.1\|WP_066652018.1\|486870_487464_-\|nitroreductase	gnl\|CDD\|380315	cd02138, TdsD-like, nitroreductase similar to Burkholderia pseudomallei TdsD. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.	1.53547e-70
NZ_CP009755.1\|WP_081984594.1\|482987_483761_+\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.52637e-46
NZ_CP009755.1\|WP_066652028.1\|496335_497289_-\|aldo/keto-reductase	gnl\|CDD\|381307	cd19081, AKR_AKR9C1, AKR9C family of aldo-keto reductase (AKR). Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).	1.69059e-148
NZ_CP009755.1\|WP_066652044.1\|505790_507242_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	8.79915e-51
NZ_CP009755.1\|WP_066652042.1\|504897_505794_+\|UbiA-family-prenyltransferase	gnl\|CDD\|172161	PRK13595, ubiA, prenyltransferase; Provisional.	2.40474e-130
NZ_CP009755.1\|WP_066652030.1\|497380_498025_+\|hypothetical-protein	gnl\|CDD\|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	5.31295e-05
NZ_CP009755.1\|WP_144411218.1\|503992_504868_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|377115	pfam03734, YkuD, L,D-transpeptidase catalytic domain. This family of proteins are found in a range of bacteria. It has been shown that this domain can act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. This gives bacteria resistance to beta-lactam antibiotics that inhibit PBPs which usually carry out the cross-linking reaction. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue. Several members of this family contain peptidoglycan binding domains. The molecular structure of YkuD protein shows this domain has a novel tertiary fold consisting of a beta-sandwich with two mixed sheets, one containing five strands and the other, six strands. The two beta-sheets form a cradle capped by an alpha-helix. This family was formerly called the ErfK/YbiS/YcfS/YnhG family, but is now named after the first protein of known structure.	3.54196e-14
NZ_CP009755.1\|WP_066652024.1\|493207_493759_+\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	1.11819e-68
NZ_CP009755.1\|WP_066652032.1\|500241_500931_-\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	8.32577e-46
NZ_CP009755.1\|WP_058730132.1\|507261_508059_-\|HAD-family-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.04269e-119
NZ_CP009755.1\|WP_066652019.1\|487638_488562_+\|AEC-family-transporter	gnl\|CDD\|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	2.25021e-39
NZ_CP009755.1\|WP_066657681.1\|498428_499670_+\|sodium:proton-exchanger	gnl\|CDD\|223604	COG0530, ECM27, Ca2+/Na+ antiporter [Inorganic ion transport and metabolism].	7.89469e-16
NZ_CP009755.1\|WP_066652046.1\|508197_508944_+\|hypothetical-protein	gnl\|CDD\|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	1.09297e-10
NZ_CP009755.1\|WP_066652012.1\|484169_485222_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.65666e-86
NZ_CP009755.1\|WP_066652040.1\|500953_501835_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	8.7331e-12
NZ_CP009755.1\|WP_066652020.1\|488929_489766_-\|exodeoxyribonuclease-III	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	2.67138e-113

>NZ_CP009755.1|WP_066652024.1|493207_493759_+|orotate-phosphoribosyltransferase
MTDTRDQLIQHISADAVFHGDFTLTSGKQASYYIDLRKVSLDHRVAPLIGQVMTDLLQQVPDVDAVGGLTMGADPIASAVLHQAAARGLSYDAFVVRKEPKDHGRGRQVEGPDVRGKRVVVLEDTSTTGGSPLKAAEALEREGAIIAAVAVVVDRDTGAKERIEAAGYPYFAAIGLADLGLSA
>NZ_CP009755.1|WP_066652022.1|491442_493131_-|hypothetical-protein
MSPVAPGPSGRAAVPEPVAIAPAGPPSRRRWVASGQEALGAAVALALAVIALGHVLVTERVALLWYDGDSVLLPLVERSIRLGQPFEWAMSPALFFFPELPVYLLCSLVTATPQQALALNGVLVLLAVYALVRAAANELMPAARRSARIAVSAVALGFVTAIVLTEYTATATSLELGSLLLTTTYYYGAVLAMLGTAVLVLRAVRTGRASVVVLVVTGLVAACTTASNPLYVPWSAAPVVVTLVLLSLARRVPWRPTGWMSAVLVAGSVVGYLLRIPLAPFVSLDPSTYVHPEQAGRTLAFFAALTDDRAGSARGDAELLLLFAGVVLAVGGTVWAWRVRTARTVLVATVLPLVTVVAVSVGVVVAGSETPRYLEPIVTAPLLALVAVAELVRSAVRRTRVHRPRRGVQLAAAIAAAVVLLGGAAVAPTTVSTVATARYAPADCLDRWADGRQVTGVGQFWTVRPLAAYASDDVELLQVRDTFETYPWLVDLGAYRDARPTFVVIGANDVWTTAVEDSLGAPATITHCTGFDVYDYAGTVGAAVLQRDVVGSADAIRRERGF
>NZ_CP009755.1|WP_066652020.1|488929_489766_-|exodeoxyribonuclease-III
MRVATWNVNSVRTRVGRIVDWLVREDVDVLGMQEIKCKPEQFPVEAFEAAGYQVEAHGLNQWNGVAFASRLPMEDVTRDFPGQPGFLKGHEGPDLPVEARAMGVTVDGVRLWSLYVPNGRELGDPHYTYKLDWLAQLADRTTEWLDAEPDTPLALMGDWNVAPLDQDVWDLRVFEGATHVSEPERAAFREFETRGLQDVVRPLVPEGYTYWDYKSLRFPRNEGMRIDFVLGSQAFADVTVGATIHRDERKGDAPSDHVPVSVDLDLETSLDDDRPMIF
>NZ_CP009755.1|WP_066652019.1|487638_488562_+|AEC-family-transporter
MGGVLTGFAIIGAIIAAGYVVGRVRLLGPHAQFVMSRLAFFVLMPCLLFHTIATAHIESLLSPMLWVSLVSAVTVGLVAVAVFRLVLRRSVATTTVGALASGYVNANNIGLPVAVYVLGQATAVVPVILLQLVVLAPLALTVLDAATAGGGGWRSRVVGPFRNPIIIASLVGLVCSALRLELPAPVLEPFSLVGAAAVPVVLLSFGMSLHGATPLRDRATRPDVLVASALKLLVMPAVAYVVARFVFGLDDQDVFVLTTLGALPAAQNVFNYAQRYQAAVPVARDVVLVSTIGAVPVLVVIAALLHP
>NZ_CP009755.1|WP_066652018.1|486870_487464_-|nitroreductase
MTSTPDTLSRSTDSSQPLVPLLEERWSPRSYDDTATMTDAQLDAVLEAARWAASAMNHQPRRFVAGRRGTDTFAKINDNLLGFNAAWAFRASALVVGILETTTEDGDERPFAQYDLGQSLTALTVQAHAEGLHVHQMAGIDAEGLRAAFDLPERFLPYTVTAIGTVADPSQLDEKAAEREVAPRTRLPLDEVVLVKE
>NZ_CP009755.1|WP_066652016.1|486001_486760_-|HAD-IIB-family-hydrolase
MTTPRLVAFDLDDTLAPSKSPLDPRMLETFAALLATVPVAVISGGNFQQFEQQLVHPLREREGLVLDDLHLLPTCGTAYYRWSGSDWALQYAEDLTDDEKARALAAVESQAKAAGYWESETWGEILEDRGSQITFSALGQSAPVDVKKRWDPTGEKKDHLRRLVQAELPDLEVRSGGSTSVDITRKGIDKAYGMRRLAELTGIPLDDMLFVGDRLDPEGNDYPVKALGVPCHAVEGWEDTDAFLTELIPTLR
>NZ_CP009755.1|WP_066652014.1|485286_485910_+|phosphoribosylanthranilate-isomerase
MTDQRWIKICGLSTPETVDAAVDAGADAVGFVFAAGSPRTVTADLAKELVERVPDGIDAVGVFRDQPIDEVVGIASEVGLTTLQLHGRESASDFARARDAGFFTIRAVSADDYLRETAEQRAAFDHDLLLLDAAVPGSGTLVDPATLADRVDEAWILAGGLTPANVVAAVQALDPDGVDVSSGVESERGVKDAAKIRSFVEAVRSIP
>NZ_CP009755.1|WP_066652012.1|484169_485222_+|serine/threonine-protein-kinase
MTLVDSARADTVLSGRYRLVKLIGTGGMGSVYEARDEHTYRLVAVKLFATPDSMTTADRVRQEREIRLLSMLSHPGLVPLYDAGTHEFEDGPHRFIVMELIADTTLLRRLAGGALHNYEVADLGAQLADALAYVHSRGIVHRDVKPANILINDEGASGFVRSVKLTDFGVAHFVDGSRLTNDGTIIGTAAYLSPEQVAGEPIGFATDVYSLGLVLLESLTGKQEYSGTLIEAALARLRNDPQVPAEVGVEWKDLLAKMTHRDPAKRPTAVAVANALRGGSTQITGPVPLGPDRTKHKRDHKLHRAAHKHAKRGTFTAVRRWRRRNVLVGSFATFGVLAACAAAYVAGTLH
>NZ_CP009755.1|WP_066652010.1|483765_483969_-|DUF2945-domain-containing-protein
MALSKGDEVHWNTSQGKTTGKLVEKKTKNFTFDGQDFKPTDDDPYWIIESEKSGNKAAHKESALTKK
>NZ_CP009755.1|WP_081984594.1|482987_483761_+|DedA-family-protein
MTTALTLPPTLPATTTAAGSRPEGTEDLGGLSGFVLQLIDALGEWGVALMLFVETVFPPIPSEVILPLAGFLAGAGQMNLVLVLVLATLGSYLGALVLYWLGAVIGFERTVRLLGRLPLVDEDDFRKAADWFHRHGKSAVFFGRFVPIVRSLISLPAGADRMHLVPFSVFTIIASGIWNSALVLLGAAFGTQYDKVEQYTEWIDRVLYVAIAVVVVTFVVRRIRRVRAERAEQRAAAQDGATTGAARGRRRATPAND
>NZ_CP009755.1|WP_066652028.1|496335_497289_-|aldo/keto-reductase
MPRIGTSDLHVFPLALGGNVFGWTADEQTSHRVLDAYTSAGGDFVDTADVYSAWAPGNEGGESERVIGSWLRASGKRDDVVVATKVSQHPQYSGLSASNVAAAARASLERLGTDRIDLYYAHFDDQDTPLEETVRAFDQLVQEGLVRYTAISNYSRPRAEEWIRIAKENGLALPVAIQPHYNLVTREPYESDIAPLAASEGLGVVPYFALAAGFLTGKYRTKDDFAGKDREGQVSGYFSDEGLAVVDALSRIAEAHEAEIASVALAWLQAQPDVVAPIASARNTEQLPALLASADLELGAEELRTLDEASARVPAAS
>NZ_CP009755.1|WP_066652030.1|497380_498025_+|hypothetical-protein
MTTLADDLTDPRSSVRLRAVMAAGTEARPSDLEVLVERCAVEPDLQVREALTWALVRLPAETVVPRLTHELHRPEAQARSQALHTLSKIRDGSVYPEVADRLGDDDPGVRRTAWRAAVLLAPAEEGPALARRLARELGQGDRETRLALSRALVSLGEDVVAPVLADASERRGEAVCAHVDETGRLLADPDAGSALALERARREMALGRGKRASG
>NZ_CP009755.1|WP_066657681.1|498428_499670_+|sodium:proton-exchanger
MGRSAWGRIAICIVIALPAVVFRVTGSAPNPVVDLLVFGGAVVAASFLLAWAAEAAQKDISGALAIAILALIAVLPEYAVDLYYAFRSGYDPSYEQFAAANMTGSNRLLLGFGWPLVVVISLLVARRYVRAGTLPRSATTVLQLQQSSRLDIGFLALLAVVAFLIPLMGSIPLWFGFVLLAAFVAYLWRASQAPDDGGDEEMVGMAGNIASMPQRARRWTIVALFLVAAAVILSSAEPFADALVESGSALGIDSYFLVQWLAPLATEAPEFIVAALFALRGMGGAAIGTLIASKVNQWSLLVGSLPIAHVLGGGTTGGLPLDGRQVEEFVLTASQTVLGVAIIIALRFHRWSAIALVALFAVQFVVTDTSGRWVLSGVHVVAALVVLWINRKDIVPTLRAPFRRAGAAGAPAA
>NZ_CP009755.1|WP_066652032.1|500241_500931_-|metal-dependent-transcriptional-regulator
MRLPSLSVMAEDYVKLVWKSTERGGEGLATRDIAAALGVSASTVSGNLRKLDRDGLIEHTPYYGVVLTPLGQQVAVAMVRRHRLIETYLVQRLGYSWDEVHTEAEALEHAVSETFLERVDADLGHPTHDPHGDPIPATDGSVPSSAGTLLGSVEPGACGVVDRVSDDDPALLRYFDELGVALGTHLRVERVRDYAGVIAVSRRAPDGEESLVDLPAAAASAIWLAPDAD
>NZ_CP009755.1|WP_066652040.1|500953_501835_+|CPBP-family-intramembrane-metalloprotease
MTTTAPARRRRWPVPPSLLLGLAPLVAFAAVSAWRSRPSDDYSTLGQTVEGVLGALVVPEGIAVLVLCVYVTALGWWPIATADRRRTALRWTLTAPALIAAVCVARLPLVEWGAQPVRYFLLLAVGVLFVGVFEELLTRGVLLVGLRRRLPEFGVWIASCVLFGLLHFLNVLAGAEVGATVVQVVFAASFGSTLYLARRLTGNLLAPVLLHAFWDFGSIAVSATVPTQDLVRMVPVGLLGLFAFAVLALGVVAGGLVAWRDDRGHRLLRRWRSVPPVGAPAVQGDEPRLPSAV
>NZ_CP009755.1|WP_144411218.1|503992_504868_+|L,D-transpeptidase-family-protein
MPYPKTWTTVGIAAVVVAAAAIAVPVLTGATGGDAVPAAADRTPTATARTVPSVPDVAAAALAALPEARYSAVVDGLLPVDRTVSSAEVFHLRTDAPLFGSDRQHPVARFAATDFLGQPTTVVGLRHEGDWELVLTPARRELPSAADGHAAAQTAAWVPRTALVQQVTPTSHVVISTADQTVSIESSSGRVTRSFPAGVGTSDTPTPTGVTGYLEQRYVDPSQGTGDQAIQLTSLHSSAADEPYGGSDGGLIGLHWNAAASGAVSHGCVRLSAEGVAALDALPLGTLVTVE
>NZ_CP009755.1|WP_066652042.1|504897_505794_+|UbiA-family-prenyltransferase
MTDGTGQLPRTLRSGAGATVRRLVHVSRPVLWINTIGSGLVAVWLTGALFDLRALPILIWLTLPFNLLIYGVNDVFDQDTDATNPRKGSIEGARIRQSEVRLIVWAVAVVNVPFLVAFLLTLPPLANAAILLYAVVFVCYSAPPVRFKARPYLDSLSNAAYALPLVIVPFALEEEPTWPAALGLMAWSVAKHAFDAVQDIVEDRDAGITTTAVRLGPRGTALWSGAWWVVSTVLFAVVSIPVAAVNLLIAGILVVCLLRAPSPETGHRLYRLSVAFPYIAGSFAGVLLLVSIVLGGAR
>NZ_CP009755.1|WP_066652044.1|505790_507242_+|FAD-dependent-oxidoreductase
MSRVVVVGGGIGGLTAAALLARAGHRVTLLEASDRLGGKSRRIQLGADRIDTGPSLVTFPAVWDELLRRLGGRSGEDGHLDLVRMPEVGRYFHRGEETALPVAPDHPWYPAWRRFADLHAPLADDVTRLLLADPLDRSALPAVRRLLSVYGSRLTTRAYLDGLAWLPDGLREIIAIHTLNAGVSPARTPALYASMPAIMAETGAWVPRGGVYEVVLALQRLAEAAGVEVRTGEAVTRIARGGVTTEAAHHPADLVVSALDADRLAALTGPAGPSAMSAMSALPRPRSRPRPRPRALSCSAVALYGVLREELPEGLATHSVVLPTKPDALHRSLEAGDEPADTMVFVNHYRAGELSPNPHGTVGVLLTAPADGAHYEIDHPFVRREVDRVSAALGLDRPITDLLDDHVVLDPQYYGTGGEPHGALYGAARPPWQSGPFHRPSYNDRWRPWLWRVGASVHPGGGIPAVVGGAMIATERLLRANPV
>NZ_CP009755.1|WP_058730132.1|507261_508059_-|HAD-family-hydrolase
MATRDEVECWLTDMDGVLVHENQALPGAPELIQQWLDEGTEFLVLTNNSIFTPRDLSARLRWSGLEVPEERIWTSALATADFCRSQMPGGSAFVIGEAGMTTALHEAGFIMTETAPDYVVVGETRNYSFEAITKAVRLIRDGARFIVTNPDATGPSAEGVLPATGAIAAMIEKATGKQPYVVGKPNPMMFRSAMNRIGAHSENTGMIGDRMDTDVQAGIEAGLHTVLVMTGISDQAEIDRYPFRPSEVIAGVHELVRAEPIEVEL
>NZ_CP009755.1|WP_066652046.1|508197_508944_+|hypothetical-protein
MLVDPGSPTAQPRTTTDGRTGAGAADAPTGTTPAADTAAAPRRRRGRPNVLSRQQVVDAATAIANEEGLDRLSFRALGAKLGVAPMTVHRTIGGLDDLHAELVRRTVDEFTATFVWPDDWRSVVHVFACTFRDLMRTHPLVLESHSQRAPLASTESDAVVAKVVGALQQAGLPEREAMYAFFVVYDFVVGHAGVQVGRGDSEAGRPERHRVVGEILGEHSYDDRFALGLEIITAGIEARVRTHGTTAS

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Crispr_ID: NZ_CP009755_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009755_3

1004018-1004100

Orphan

Consensus_repeat	Method
CGTGCCGCCAGCGCGAGTCTCGGC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP009755_3

>merge|NZ_CP009755|3|1004018-1004100|CRISPRCasFinder
CGTGCCGCCAGCGCGAGTCTCGGCCCCGCGGACACGTTCGCGTCTTCGGAGCCGCGAAACCGTCCGCCAGCGCGAGTCTCGGC

>NZ_CP009755|3|3|1004018-1004100|CRISPRCasFinder
CGTGCCGCCAGCGCGAGTCTCGGC	CCCGCGGACACGTTCGCGTCTTCGGAGCCGCGAAA
CCGTCCGCCAGCGCGAGTCTCGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009755.1\|WP_058727630.1\|995212_995533_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226391
NZ_CP009755.1\|WP_066653053.1\|1012670_1012994_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066657902.1\|999152_999656_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235825
NZ_CP009755.1\|WP_066653026.1\|999725_1001141_-\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_CP009755.1\|WP_066653039.1\|1008412_1009651_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341027
NZ_CP009755.1\|WP_066653011.1\|990224_992672_-\|malto-oligosyltrehalose-synthase	unknown	unknown	gnl\|CDD\|237740
NZ_CP009755.1\|WP_066653055.1\|1013110_1013638_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|237597
NZ_CP009755.1\|WP_066653047.1\|1010478_1010739_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP009755.1\|WP_066653050.1\|1011331_1012501_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP009755.1\|WP_081984720.1\|1002666_1003989_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173852
NZ_CP009755.1\|WP_081985239.1\|998311_999022_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NZ_CP009755.1\|WP_081985238.1\|996548_998219_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP009755.1\|WP_066653044.1\|1010158_1010449_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066653041.1\|1009647_1010097_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP009755.1\|WP_066653008.1\|988473_990228_-\|malto-oligosyltrehalose-trehalohydrolase	unknown	unknown	gnl\|CDD\|274114
NZ_CP009755.1\|WP_081984718.1\|995718_996468_+\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|227065
NZ_CP009755.1\|WP_066653028.1\|1001242_1002670_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274819
NZ_CP009755.1\|WP_066653030.1\|1004140_1004485_-\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240572
NZ_CP009755.1\|WP_066653033.1\|1004529_1006629_-\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NZ_CP009755.1\|WP_066653036.1\|1006885_1007524_-\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429

Protein	Function_ID	Function_description	E-value
NZ_CP009755.1\|WP_058727630.1\|995212_995533_+\|hypothetical-protein	gnl\|CDD\|226391	COG3874, COG3874, Uncharacterized conserved protein [Function unknown].	4.53463e-07
NZ_CP009755.1\|WP_066657902.1\|999152_999656_+\|hypothetical-protein	gnl\|CDD\|235825	PRK06547, PRK06547, hypothetical protein; Provisional.	1.67476e-48
NZ_CP009755.1\|WP_066653026.1\|999725_1001141_-\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.82892e-159
NZ_CP009755.1\|WP_066653039.1\|1008412_1009651_-\|MFS-transporter	gnl\|CDD\|341027	cd17474, MFS_YfmO_like, Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.19147e-78
NZ_CP009755.1\|WP_066653011.1\|990224_992672_-\|malto-oligosyltrehalose-synthase	gnl\|CDD\|237740	PRK14511, PRK14511, malto-oligosyltrehalose synthase.	0
NZ_CP009755.1\|WP_066653055.1\|1013110_1013638_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|237597	PRK14054, PRK14054, peptide-methionine (S)-S-oxide reductase.	7.74959e-84
NZ_CP009755.1\|WP_066653047.1\|1010478_1010739_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	1.03196e-09
NZ_CP009755.1\|WP_066653050.1\|1011331_1012501_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.51079e-05
NZ_CP009755.1\|WP_081984720.1\|1002666_1003989_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173852	cd01163, DszC, Dibenzothiophene (DBT) desulfurization enzyme C. DszC is a flavin reductase dependent enzyme, which catalyzes the first two steps of DBT desulfurization in mesophilic bacteria. DszC converts DBT to DBT-sulfoxide, which is then converted to DBT-sulfone. Bacteria with this enzyme are candidates for the removal of organic sulfur compounds from fossil fuels, which pollute the environment. An equivalent enzyme tdsC, is found in thermophilic bacteria. This alignment also contains a closely related uncharacterized subgroup.	9.95804e-126
NZ_CP009755.1\|WP_081985239.1\|998311_999022_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	9.03235e-24
NZ_CP009755.1\|WP_081985238.1\|996548_998219_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	1.00835e-67
NZ_CP009755.1\|WP_066653041.1\|1009647_1010097_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	9.07775e-13
NZ_CP009755.1\|WP_066653008.1\|988473_990228_-\|malto-oligosyltrehalose-trehalohydrolase	gnl\|CDD\|274114	TIGR02402, Malto-oligosyltrehalose_trehalohydrolase, malto-oligosyltrehalose trehalohydrolase. Members of this family are the trehalose biosynthetic enzyme malto-oligosyltrehalose trehalohydrolase, formally known as 4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase (EC 3.2.1.141). It is the TreZ protein of the TreYZ pathway for trehalose biosynthesis, and alternative to the OtsAB system. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP009755.1\|WP_081984718.1\|995718_996468_+\|ECF-transporter-S-component	gnl\|CDD\|227065	COG4721, COG4721, ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism].	3.59622e-39
NZ_CP009755.1\|WP_066653028.1\|1001242_1002670_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP009755.1\|WP_066653030.1\|1004140_1004485_-\|metallopeptidase-family-protein	gnl\|CDD\|240572	cd12952, MMP_ACEL2062, Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein. The subfamily includes an uncharacterized protein from Acidothermus cellulolyticus (ACEL2062) and its homologs from bacteria. Although its biological role remains unclear, ACEL2062 contains a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets and a HExxHxxGxxD/S (x could be any amino acid) motif. It may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD motif.	1.59962e-38
NZ_CP009755.1\|WP_066653033.1\|1004529_1006629_-\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	2.1674e-64
NZ_CP009755.1\|WP_066653036.1\|1006885_1007524_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	4.0717e-105

>NZ_CP009755.1|WP_081984720.1|1002666_1003989_+|acyl-CoA-dehydrogenase
MTDATTSTGGAPGLPSDRPDDVPASAGGAPCLPADRLAVLRARFAPVVEAIREGAVARELASGTPGDRDLPHAEVRALADAGFGRLRVPEERGGFGVTLVELAHLVADLAAADSNIAHLWRGHFGYTELVLLRPDSPARDEWLQRIVGGAIVGNATSERTGTTLADISTTVAPDDSGTWRLDGRKFYSTGTLYADWIYLAADRDGERVTFAVPTGAPGVTGVDDWDGFGQRLTASGTTVFDGVAVDPAVVSAYRDAPLSHIQAFYQLYLLAVLAGIGQAVVDDAVAFVRPRTRTYIHANAAVPGEDPQVLAVLGRLSAGAFTARSLVVAAAGLLDGVVATNEPGVGVDHALLDAAENAVYQAQVEVGPRVLQAATELFEVGGASAADRTRALDRHWRNARVVASHNPAVYKERLVGEYVLHGRGPVDAWERYHEVGPTRF
>NZ_CP009755.1|WP_066653028.1|1001242_1002670_+|LLM-class-flavin-dependent-oxidoreductase
MSDAPTRPLRFAAFVMNTTSHIQHGLWRHPDARQADFDDVTLWTDLARTLERGKFDAMFFADVVGTYGPARGDYATNLREGLQIPSNDPSVLLSALAVSTEHLGLAFTSSVIQAHPFDFARKVSTLDHITRGRIGWNVVTSALDSAARNFGADRLEEHDERYAWAEEYLEVCAKLWEGSWEDGAVLKDPVRGYADPELVHRIDHHGKRYDVQGPHLSAPSPQRTPVLFQAGSSPAGRAFAARNAEAQFILTSNRDATEQLIRETRDLAAAVGRRREDIAFFLGLTFVTGSTEAEAKAKEAEIDEYLAADGFLVHSNLGFDPDTGEPLDPATPLSEVRTQAGQSHLQWLREAAGDREPTIADLARLSAKLRARVVGTPEQIADELAAWQRVGVDGVNVINWTLPGSYEEFVDHIAPTLQERGLMQSEYREGTLREKLFGHAQLPDSHPARRWRGAFSGGAAGTGADEARDAVEVTA
>NZ_CP009755.1|WP_066653026.1|999725_1001141_-|MHS-family-MFS-transporter
MPTQTTAAAPPVRPPSPSTNATRRRVALASFVGTTVEYYDFYLYATASALVFAPTFFPSVTPAVGVIASFATYGVGFVARPLGGIVAGHLGDRIGRKKLLVASLVLMGIASTLIGVIPSAATIGVGAVVALVVLRLLQGVAAGAEWGGSALLSVEHAPTRHRGLFGAFTQMGSAGGMLLATGVFTLVRTLLGNEAFLAWGWRLPFLFSAVIVAVGLVIRLGVQDAPVFQALRASGGVERFPVWQAVRRHPRSILVTAGLRLVQPALYSILTTYSLTYLGAKRGEEGSAAGLQAVLVISAVSLVSTPFWGWLSDRVGRRPLAIGSAIGIGVLIWPFFAFLDAGPLVLLPFVALIGMSVFHDSIYGPQAAWFAEQFPTGRRYSGMSLGYQIGSIFSVGLTPLLAAVFVEVGGGSPWILCAYLGVYAVLSVVAAVFAVDPVRDGRRADARAAGAGAGAGAGDGAGAGAGGPVSG
>NZ_CP009755.1|WP_066657902.1|999152_999656_+|hypothetical-protein
MAAAAAGAAAATGRRLVVLVDGRSGTGKTTLGDAVAARLGARVVHLDDVYPGWDGLRAAADAVVSDVLGTPSGYRRWDWERSEPAEWVSIESHVPLVVEGCGALSRGSAPHATLRVWLEADDDVRRDRAIGRDGEVFAREWERWAAQERAFIAAEAPAELADLVLRT
>NZ_CP009755.1|WP_081985239.1|998311_999022_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MLGVLALGLCLVTSLDVVSAAVALALELLLLPVLRIPPRTLLLRASPVLVAVPLTALSIALYGRPSGREWFDLGFVHVTDGSLTLALATALRVLAVGLPAVVLFVGVDPTDLADGLAQLLRLPARFVLGALAAVRMTTLLGEDWRQLARARRARGLADHGRLRRGASMAFALLVLALRRATTLAVAMESRGFGAPGPRTWARQARFAGPEWAMVAVLVGIGVASIGVAVAAGTWRA
>NZ_CP009755.1|WP_081985238.1|996548_998219_+|ABC-transporter-ATP-binding-protein
MRGLDLVVEPGDRVAVVGPSGAGKSTVLRAVAAVLADEPDPDDDTAAAVQGSVLVDGADPRAVRGRVGLVMQDPEAHTVMSRIGDDVAFGCENTGVPRAETWERVRHALGVVGLDLPLDRSTSRLSGGQRQRLALAGVLAMRPGVLVLDEPCANLDPEGVAQVHDAVRALLDTSGATMLVVEHRIGTWLDLVDRLVLLEPGGGVVADGTPASVLAEHGPALTAAGVWVPGAEPARGSSRAGGGRPVAPSTGAGRPVAPSTERAGGSAPGAPVAGGAFRPRDEETALLEARGLATARGGILGRAGGTRVGSGIDLGVRRGRVLAVTGPNGVGKSTLGLTLAGLLRPSGGTLLATPDLAGDAGEAPIRWTSRQLAVRIGSVFQDPGHQFVARSVREELGAGPRALGLSDADARVEELLDAFGLRHLADANPFTLSGGEQRRLAIGAVVASRPPVVVLDEPTSGQDRATWQAVVDLLGALAEAGTALVVVTHDRDLVRALDADEVVLAADGARAVPPAGTAVPPDGRSGPSAGPGAPSAGPDAPSTGPGGPRPTTEVHR
>NZ_CP009755.1|WP_081984718.1|995718_996468_+|ECF-transporter-S-component
MPASTQSAAPSTTVRRSLRWRVVDIVVASVLAVAIGVVFKLWEFGYEPISAVAALVLPGTQALFGGVWLLAGPLVAIVVRKPGAALYAEMVAASVEALLGTQWGWLTLEAGLVQGLGAEVVLALFLYRAYRLPVVVLAGAAAGLALGINDTVLWYPGLDAAFKTVYVVSAVVSGAVIAGLGSWLLVRALAATGVLSSFAAGREHARRTHATTPQESSAPTGATVPLDGAQSGTATPAAEQAERGSRAAR
>NZ_CP009755.1|WP_058727630.1|995212_995533_+|hypothetical-protein
MANIVSQIADKVRPVGVSTNYGEPVEVGDQTLIPVSIGWFGFGAGGDDENGGGGGGGASIPVGAYVRRPGQDLQFEPNLISLLAVSIPTIWVTGKALSKVIRALKK
>NZ_CP009755.1|WP_066653011.1|990224_992672_-|malto-oligosyltrehalose-synthase
MSARRVPTSTYRLQVTADFDLDAARGVVDHIRTLGADWVYLSPVLQAEPGSQHGYDVVDHSHVDTERGGDAALRALAEAAHAAGLGVLVDIVPNHVGVATPEANPWWWSLLESGQGSPVAWAFDVDWQAGDGRIRIPVLDDRLLDAVELRDGRLYVGETAYPAAEGTVQDGDDVAAVHARQHYEFVHWKRADHDLNYRRFFAVNTLAAIRVEEPEVFASSHATIGGWFRDGLVDGLRIDHPDGLYDPAGYLQDLHDLTGGAYTLVEKILEPGEQLPSSWPVDGTTGYDALAVVDRVFVDPAGEPALTAASGAEPADWQQLTHDTRRGIADGILGSEVRRLARLLAPVAPDVPEDRVVDAVAEIVASFEVYRTYLPEGVHHLIDALERAAEARPDLDDVIDRIAPALVDPGHAAAVRLQQTSGMVMAKGVEDTAFYRTSRLTTLSEVGADPSLFAVSVEDFHQAQRDRQGSWPHTMTTLTTHDTKRSEDTRARISVLAELGSEWADALARLRSLAPLDDAVMADLLWQAIVGARPASRDRLHAYAEKASREAGDSTTWTEPDEAFEEQMHALVDASFDDPQVVAVLDELDQVINAAGWSNGLAQKLVQLTMPGVPDVYQGTEGWDRSLVDPDNRRPVDYAELRHVLAGLDGPEDDGPERLPAVGLDGAVKTLVVSRALRLRRDHPELFTRYLGLEATGSAADHVLAFDRGGAVTVATRLPVGLERVGGWGDTLVHPVPLDRVDLLTGRRFPASRGIALAELLTDLPVALLVPADLADAGAAAASSSTSTTTPAASGSDGTAVSDQQAEIEILEGHA
>NZ_CP009755.1|WP_066653008.1|988473_990228_-|malto-oligosyltrehalose-trehalohydrolase
MTVPARYAVWAPNPERVRLVVDDVEYALTRGDDDWWSTDEVAPVVGARYGFRIDDDEDVRPDPRSRYQPDGVHGTSEVVDPERFAWTDEAWTGRPARGGVIYEMHIGTYTPEGTLDAAAAKLDHLVELGVEFVELLPVNAVNGEWNWGYDGVGWFAVHHPYGGPDAYDRFVDTAHALGLGVIQDVVYNHLGPSGNYLPLYGPYLLQGLGNTWGDSVNVEHPEVRRYVLDNVRMWFRDHHVDGLRLDAVHAIRDTTRPHVLQVMASETESYSEFVGRPLSLIAESDLNDPVMFRPQEASGYGLTGQWSDDFHHAVHVALTGETNGYYADFAPLSALAKVLEHGFFHDGTWSSFRGKRHGRPIDRGTSPATALVVANQNHDQIGNRAAGDRLAASLDDESLVIAAALTLLGPFTPMLFMGEEFAATTPWQFFTSHPEKALGEITAKGRIAEFAEHGWDESVVPDPQDPTTFSNSKLDWADVTSERGARILRAYRVLVALRRTEQAFVDHRYEANAVRFDGDDRWLVLTRGLLGPDAAPVHVVVNFADDAAEVSVPDATGEELYRFGEASVDAGVVRFASRGVVVLR
>NZ_CP009755.1|WP_066653030.1|1004140_1004485_-|metallopeptidase-family-protein
MEMSADEFEQLVTDELDRLPDEMVDGLDNVVFVVEDEPEDGSDLFGYYDGVAATERGQYGFGELPDRIVVFRKQHLEECDTVEELRDEVHTTLVHEIGHFYGIDDARLHELGWA
>NZ_CP009755.1|WP_066653033.1|1004529_1006629_-|acyltransferase
MTSANKRRPDIEGLRGIAVLMVLLEHTFATPVGGFLGVDVFFVISGFVVGRGLLNEGATHGQIRIIDFFRRRARRLAPTALLVVGLTMAVSALFLRGSRREQTLFDGLAGLLGTANWRFITSDASYFDGASAPSPFRHLWSLGVEEQCYFLLPLALLLVIRRRRLGLFVITAVVVASFAAAVATTAPQPVFAFYSTVTRLWQLGTGVGLALVAHRLEGLGPAPARAPRRTAVMAVSGLLLLVASALLIRPDVGVPFPAGLAPAAGTAMIIAAGCGAPTMVTKLLGARPLVLVGERSYALYMWHWPVLVLAPAVLGTEPVVALAIAVAAAVLSHAFVERPIRRRGSAKSQPTLAHGHRSARLEQSAGAVVALAIIATVTTASAVTRYEATAPPAPEPSAVDPSEPGPATVETERRRAVEQGLSLRSWPDSLQPQLDELRGHDYLPALEQDTRFEQVARCAEPGQNHTVEQCTLGDGSRSLMIVGDSTAEFLTPAFRWMTEHRSGWKLIAGARYGCPFSTLELAHGDTDCSKAREEVVAHIAQASPDVLVVMNVLGPLQLHGTDVPESDRAAGVIARIDEVRAAVGSVAIVGPNVPGPKWDDCGSALIGPEACTGTTQRWRPSISADQDAARRSHIPYIDPTALWCAGGRCPAVIDDRAVSFDGTHATFEAAEDVAPALEDALVSAGVLPPQDGSTGGAAG
>NZ_CP009755.1|WP_066653036.1|1006885_1007524_-|oligoribonuclease
MATANDRLVWIDCEMTGLDVEVDQLVEVAVVVTDFDLVPVHPGFDIVIKPDQSALDNMNEFVTNMHATSGLAEAIPDGVSLADAEYQVLEYILQHVPAEGSAPLAGNTIGTDRAFLSKYMPRVDGHLHYRSVDVSSIKELCRRWFPRVYFNAPEKHGGHRALADILESIRELEYYRRAGFIPEPGPTTEDVRAVAAEVVEKWEPRLGQPTAE
>NZ_CP009755.1|WP_066653039.1|1008412_1009651_-|MFS-transporter
MNAHAPAASGSILKQSSAVWAIAFACVVAFMGIGLVDPILPAIATSLHATAAQTELLFTSYLAVTGVAMFFTSWVSSRIGAKNTLLIGLALIVVFSVLAATSGSVWNIIGFRAGWGLGNALFISTALATIVGAASGGTASAIILYEAALGLGIAVGPLVGGLLGSVSWRGPFFGVTTLMAIAFIAVVALLKTSGLEKPTPTKLSAPFRALGQPALAALAVTALFYNIGFFVLLAYTPFPLGFGALGIGFTFFGWGVGLAITSVWVAPMLTARMRRTTVLKIALPLLALDLFAAAVVVTSQAGLIICVVIGGLVLGVLNTVLTECVMEATDLPRSVASSAYSAVRFIGGAIAPPVATLLADSFSPSAAYVFAGVSVAVAFVVVVLTTKVLRRVDDGAEPERVEAEAISAGEMV
>NZ_CP009755.1|WP_066653041.1|1009647_1010097_-|MarR-family-transcriptional-regulator
MESSRAQALETLIISVNRLVRAAAQASGDATSAAVWRTLGILETEQPLRLGELAAASRVAQPTMTRIVAGMLTDGLLSRTVDPDDSRGQLIELTDAGRERLATWRATIADSVGPVFADLDDDDWDVLRDAAAIIASRTTTNPTRTEIHA
>NZ_CP009755.1|WP_066653044.1|1010158_1010449_+|hypothetical-protein
MSDITIHEGDEYTAIFHGGPFDGTTDTRTATSDAVDDEVTVYADVEGLQTAFAYKATKTRQVLDQTSVEYEYDAADSDPVDDLQDRGDRSGEFDRE
>NZ_CP009755.1|WP_066653047.1|1010478_1010739_+|thioredoxin-family-protein
MQLDLWTSAFCAPCAAARRVSGEAAALVPGLRVTERDVAAHPDTAEDLGIRSTPTIIVRRDDGAEVFRSPGVPSRDQLLVAVAKAL
>NZ_CP009755.1|WP_066653050.1|1011331_1012501_-|hypothetical-protein
MDWWNDLTDWTASDEGWRVLSGAIIPFVAIVVAGVIAALIGRAATKRVVALHDRESRNAAVAGVVTAARKASRWGALGHEERAYADHLAEDADVRLRLLPVSGAPLAADWVQHEIADIKRNSSTFTSQADQSLGELRDRLLEWNGKPGRAKKLFKADLERWKFDSPDPDADLIARQQDWNAGQQQQRSAEADASTAPSRPTPTTTSFRPAPQQSPVGSPAAGTSASRTSGPTAAATVDQDATTPIDDVRGAADNRTRPYGDRETVQLDGTPVRPPLGSPIASARPGNGTTPSARNDLGSRSDDSSDSGEVDVTDRGGDARSDDRPTSAPRVASPTSADAHVNRAATSATGLDRPGAANATPGAREDDDASPYTQPISASELRRRAAEDD
>NZ_CP009755.1|WP_066653053.1|1012670_1012994_-|hypothetical-protein
MVSRTVEATKTTTNQQEAPVQTSTEPAFRIRSTPVARSRGDLRVLDVRDDLSRVTRTNGEIVGYVDRVDVAGGTAYRARRYVAVERRFVELPNVWSADDAVDCLRWG
>NZ_CP009755.1|WP_066653055.1|1013110_1013638_+|peptide-methionine-(S)-S-oxide-reductase-MsrA
MTTFVLAGGCFWCLDAVYRTLQGVQDVVSGYTGGVVEDPTYEAVCTGATGHAEAVAVTFDESVIPADVVLDVFFTLHDPRQLNRQGADVGTQYRSAMFPADDEQRALFEHAVQRAADIWDGGIVTTIEPLGTFFRAEEHHQDFFAKNPGQGYCLAVALPKVNKVRKAYSQYILAS

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Crispr_ID: NZ_CP009755_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009755_4

1124658-1124738

Orphan

Consensus_repeat	Method
CGGAGGGCGCCGCTGATGGGCATCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009755_4

>merge|NZ_CP009755|4|1124658-1124738|CRISPRCasFinder
CGGAGGGCGCCGCTGATGGGCATCGCCACTGACTCGCGCAGCTTCGCATCCCTGGGCGGAGGGCGCCGCTGATGGGCATCG

>NZ_CP009755|4|4|1124658-1124738|CRISPRCasFinder
CGGAGGGCGCCGCTGATGGGCATCG	CCACTGACTCGCGCAGCTTCGCATCCCTGGG
CGGAGGGCGCCGCTGATGGGCATCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009755.1\|WP_066653214.1\|1116303_1117503_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|238634
NZ_CP009755.1\|WP_066653225.1\|1119852_1121277_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NZ_CP009755.1\|WP_066653211.1\|1114960_1116193_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP009755.1\|WP_066653249.1\|1135779_1136226_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_CP009755.1\|WP_066653220.1\|1119002_1119509_+\|8-oxo-dGTP-diphosphatase	unknown	unknown	gnl\|CDD\|239519
NZ_CP009755.1\|WP_066657947.1\|1121611_1123300_-\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|223104
NZ_CP009755.1\|WP_066653209.1\|1111152_1112685_+\|CYTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|143620
NZ_CP009755.1\|WP_066653216.1\|1117641_1118532_-\|aminodeoxychorismate-lyase	unknown	unknown	gnl\|CDD\|236114
NZ_CP009755.1\|WP_066653239.1\|1129905_1130742_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381358
NZ_CP009755.1\|WP_081984748.1\|1134575_1135676_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376532
NZ_CP009755.1\|WP_066657945.1\|1112792_1114964_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224684
NZ_CP009755.1\|WP_066653246.1\|1133438_1134491_-\|M4-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341060
NZ_CP009755.1\|WP_066653218.1\|1118567_1118918_-\|tryptophan-synthase-subunit-alpha	unknown	unknown	unknown
NZ_CP009755.1\|WP_066653235.1\|1125151_1126636_+\|aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|237031
NZ_CP009755.1\|WP_066653223.1\|1119505_1119805_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_058728797.1\|1129534_1129906_+\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|223619
NZ_CP009755.1\|WP_066653237.1\|1126739_1127828_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP009755.1\|WP_081984746.1\|1128004_1129321_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|236700
NZ_CP009755.1\|WP_066653244.1\|1133142_1133421_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066653241.1\|1130906_1133153_+\|ATP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|226482

Protein	Function_ID	Function_description	E-value
NZ_CP009755.1\|WP_066653214.1\|1116303_1117503_+\|amidohydrolase	gnl\|CDD\|238634	cd01309, Met_dep_hydrolase_C, Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	2.45494e-132
NZ_CP009755.1\|WP_066653225.1\|1119852_1121277_-\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	1.14921e-12
NZ_CP009755.1\|WP_066653211.1\|1114960_1116193_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	5.65538e-27
NZ_CP009755.1\|WP_066653249.1\|1135779_1136226_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	4.99971e-10
NZ_CP009755.1\|WP_066653220.1\|1119002_1119509_+\|8-oxo-dGTP-diphosphatase	gnl\|CDD\|239519	cd03427, MTH1, MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the incorporation of such oxygen radicals during replication. This is an important step in the repair mechanism in genomic and mitochondrial DNA. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for activity, and contain the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as a metal binding and catalytic site. MTH1 is predominantly localized in the cytoplasm and mitochondria. Structurally, this enzyme adopts a similar fold to MutT despite low sequence similarity outside the conserved nudix motif. The most distinctive structural difference between MutT and MTH1 is the presence of a beta-hairpin, which is absent in MutT. This results in a much deeper and narrower substrate binding pocket. Mechanistically, MTH1 contains dual specificity for nucleotides that contain 2-OH-adenine bases and those that contain 8-oxo-guanine bases.	5.07556e-33
NZ_CP009755.1\|WP_066657947.1\|1121611_1123300_-\|sodium:proton-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	5.15694e-73
NZ_CP009755.1\|WP_066653209.1\|1111152_1112685_+\|CYTH-domain-containing-protein	gnl\|CDD\|143620	cd07374, CYTH-like_Pase, CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases. CYTH-like superfamily enzymes hydrolyze triphosphate-containing substrates and require metal cations as cofactors. They have a unique active site located at the center of an eight-stranded antiparallel beta barrel tunnel (the triphosphate tunnel). The name CYTH originated from the gene designation for bacterial class IV adenylyl cyclases (CyaB), and from thiamine triphosphatase. Class IV adenylate cyclases catalyze the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. Thiamine triphosphatase is a soluble cytosolic enzyme which converts thiamine triphosphate to thiamine diphosphate. This domain superfamily also contains RNA triphosphatases, membrane-associated polyphosphate polymerases, tripolyphosphatases, nucleoside triphosphatases, nucleoside tetraphosphatases and other proteins with unknown functions.	3.06491e-30
NZ_CP009755.1\|WP_066653216.1\|1117641_1118532_-\|aminodeoxychorismate-lyase	gnl\|CDD\|236114	PRK07849, PRK07849, aminodeoxychorismate lyase.	1.15342e-109
NZ_CP009755.1\|WP_066653239.1\|1129905_1130742_+\|aldo/keto-reductase	gnl\|CDD\|381358	cd19132, AKR_AKR5D1_E1, AKR5D and AKR5E families of aldo-keto reductase (AKR). 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).	6.90956e-154
NZ_CP009755.1\|WP_081984748.1\|1134575_1135676_-\|hypothetical-protein	gnl\|CDD\|376532	pfam01341, Glyco_hydro_6, Glycosyl hydrolases family 6.	7.71853e-50
NZ_CP009755.1\|WP_081984746.1\|1128004_1129321_-\|MFS-transporter	gnl\|CDD\|236700	PRK10489, PRK10489, enterobactin transporter EntS.	5.06012e-49
NZ_CP009755.1\|WP_066653246.1\|1133438_1134491_-\|M4-family-metallopeptidase	gnl\|CDD\|341060	cd09597, M4_TLP, Peptidase M4 family including thermolysin, protealysin, aureolysin, and neutral protease. This peptidase M4 family includes several endopeptidases such as thermolysin (EC 3.4.24.27), aureolysin (the extracellular metalloproteinase from Staphylococcus aureus), neutral protease from Bacillus cereus, protealysin, and bacillolysin (EC 3.4.24.28). Typically, the M4 peptidases consist of a presequence (signal sequence), a propeptide sequence, and a peptidase unit. The presequence is cleaved off during export while the propeptide has inhibitory and chaperone functions and facilitates folding. The propeptide remains attached until the peptidase is secreted and can be safely activated. All peptidases in this family bind a single catalytic zinc ion which is tetrahedrally co-ordinated by three amino acid ligands and a water molecule that forms the nucleophile on activation during catalysis. The active site is found between two sub-domains; the N-terminal domain contains the HEXXH zinc-binding motif while the helical C-terminal domain, which is unique for the family, carries the third zinc ligand. These peptidases are secreted eubacterial endopeptidases from Gram-positive or Gram-negative sources that degrade extracellular proteins and peptides for bacterial nutrition. They are selectively inhibited by Steptomyces metalloproteinase inhibitor (SMPI) as well as by phosphoramidon from Streptomyces tanashiensis. A large number of these enzymes are implicated as key factors in the pathogenesis of various diseases, including gastritis, peptic ulcer, gastric carcinoma, cholera and several types of bacterial infections, and are therefore important drug targets. Some enzymes of the family can function at extremes of temperatures, while some function in organic solvents, thus rendering them novel targets for biotechnological applications. Thermolysin is widely used as a nonspecific protease to obtain fragments for peptide sequencing. It has also been used in production of the artificial sweetener aspartame.	5.25078e-117
NZ_CP009755.1\|WP_066653235.1\|1125151_1126636_+\|aspartate-ammonia-lyase	gnl\|CDD\|237031	PRK12273, aspA, aspartate ammonia-lyase; Provisional.	0
NZ_CP009755.1\|WP_058728797.1\|1129534_1129906_+\|peptidylprolyl-isomerase	gnl\|CDD\|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	1.78507e-40
NZ_CP009755.1\|WP_066657945.1\|1112792_1114964_-\|S9-family-peptidase	gnl\|CDD\|224684	COG1770, PtrB, Protease II [Amino acid transport and metabolism].	0
NZ_CP009755.1\|WP_066653237.1\|1126739_1127828_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	6.77623e-49
NZ_CP009755.1\|WP_066653241.1\|1130906_1133153_+\|ATP-binding-domain-containing-protein	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	1.89482e-82

>NZ_CP009755.1|WP_066657947.1|1121611_1123300_-|sodium:proton-antiporter
MDTAELLILLIGSLAVTGFARAKGLPAPLLVTAVALAVSFLPGLPEIEIDSEVILTVVLPPLLYSAALDVSWQSFRQSIKQIRRLGIFLVIVTALAVALAAYIIIPDMDWPAAILLGAVVAPPDAVSAAAIGRKLGLPRRVMTVLSGESLINDAASLTLVRVFTLIAAGTSLTIWQDLGIFGLAIGVGLAVGIVLGVAVHWIRMRINDPVVETIMSILLPFVAYVLAEHLSGSGVIAVVTAGLYIGYNSPKEGYATRLQERPLWTSADVILEGFVFALIGLQLKTVVQDLVESDRSLTQTLTAAAVVLVVVILVRPLFVFESYARNRFNGRWLRPLRVRLSRGHPSLRWLRGSAEPKLNWRELTVISWTGMRGVVTLAAAVSVVGNSVDVKAQDTIFVIAFVVTVGTLLLQGLTLPFVIRALKVQDPAEGEADVRSEMRLNQRTTEAAIALLERRRSAWSEQYGDQAVDSVVSRLKARLERQAETFRRDAEEEEDEERNAPLRLRGAQIQDIRRELLDRRREIVLEEREKGNLDEEVMRRVLVTLDAEELAMDSAQASRSRS
>NZ_CP009755.1|WP_066653225.1|1119852_1121277_-|ABC-transporter-permease
MRQAPVPEPQRISRYRRWYGTLHPSLQLIGLQLWMPLFFIVGFCLCYVFAFHAPHPHGVPVALVGSDPTLVAAVGKALPGEYVFHTYESLARAKQDVLAGTMAVAYDPSANEVFKASAHQFQVASLVPATLTSVLTGIGVAAPTVTELAPLPAYDEYGTVAMYVMLAWCIGGYMVAMFIGIMGGPLRHRTRMTVIVVGGLVISLITNTLAGPVVGAIHGHWIGLVLIAWGWIVAIGLAVNGLSYFVGRFIAAPAMICFVFLSMPSSGGAYPKWFMPEPFAWLNHVVVGSSMVDMIKHEIYGVGPGFGRGLVTMGCYAAAGLVLMFFGKQWWERRRIAAIVNNRTTMFQDAQTANREFLGKQRDAELERHGLTSTETGTLSVLRDDDWEDERVAGDVFTGGRDGLEQETTPTGRIPVVRQADRSGPARPGGAATGPRTRPVPRVDASGRRPAPAGSRTTRTGAPDERQHGRHAER
>NZ_CP009755.1|WP_066653223.1|1119505_1119805_-|hypothetical-protein
MHPRTAWHRVLVTAVVAFLVLAAALYAASVFLAPADGRNTAGLFVGWAMFAVLGAIAAGIVDFFVRPLGGRSGDADVLAAAEEARTGSTRVQQGRAGAR
>NZ_CP009755.1|WP_066653220.1|1119002_1119509_+|8-oxo-dGTP-diphosphatase
MTERDETKSQHAPVVVVYLLRDGPDGPEVLLGEKRRGLGAGRLVGPGGKREPGEPPVAAAVREVAEEVGLRLESDDLEARGTLDYRFPFRPSWSQRSDVFVCRRWQGTPSGSDELEPRWVPVDAVPYDAMWDDARYWLPGVLAGGTVTARFTFAEDNATVSGFSGEGV
>NZ_CP009755.1|WP_066653218.1|1118567_1118918_-|tryptophan-synthase-subunit-alpha
MAEPRRTGRSLEVLRAEAAEEISMIVEHRSRAGEDPWEFMPTLPTVDEQVVLILRADAVELDAAIGQRSVHWAGHPASGQGTELGEEYHRLRRIALQHPELTPAVWKLMGALPGRD
>NZ_CP009755.1|WP_066653216.1|1117641_1118532_-|aminodeoxychorismate-lyase
MTDTVLAVLNQPSRDAAPHDPEADAYTWAKPLEEHLQVQDLGAIRGDGVFETITVVDGRPQALEPHLARFVRSAAMLDLPTPDVDAWRQAIEAVCARLDPVHEAFAKTVMTRGVEGSGRPTGWVYAAPSGDQTPARTAGIAVVTLDRGYRHDVERTSPWLLQGAKTLSYAVNMAALREAERRGADDALFVSTDGYVLEGTRANLVMSVDGRFVTPRTDIGILAGTTQADVFRFAEGEGIATSYELVTLADLEASDALWLLSSVRQAAPIRSVNGVAREMDLPMTERINDFLLSRDA
>NZ_CP009755.1|WP_066653214.1|1116303_1117503_+|amidohydrolase
MRNSFVVTGAHVVPVTAPPFDGGAVVVEDGRITAVGPDVAPPPGLPVVDAAGAWLVPGFVESHGHVGIHEEANGWAGNDTNEMTDPNQAAVRAIDAVDIDDEGFRDALSGGITSIVVKPGSGNPIGGQTVAIKTWGGRTIDEQLISDAVSVKSALGENPKRVYGDKGRTPSTRLGVAKVVREAFVAAQDYRAARAAAAAKGEPFTRDLTNETLVRVLDGELAWDQHVHRHDDLATALRLADEFGYRLVVNHGTEAHKIADLLAERDVPVIYGPLFTSRSKVELRDRGIPNVVALAAAGVRVAITTDAPVVPIAMLVDQATAAVKEGLPWQTALEALTTNPAAFLGFGDRVGRIAPGFDADLVLWDGDPLAATSRATRVWIEGTSVYEWADGTGVTTPRW
>NZ_CP009755.1|WP_066653211.1|1114960_1116193_-|Fic-family-protein
MSRPRPPWPAHDTVVRPWRSATRGDRTVRQTATVTASVPPCIADAHWEPDGATAALLDRSLTALRALDEDGGAGPLHRLLTRTEAVATSRIEHEDATAEDVARALVGVRANTSASVMVQAGDALERLVRAAGAGHLDETALLDAHRGLLRGDPVDGPHAGRYRTVQNWIGGGRTPRDADHVPPPPEFVPSLMADLFAFLARDDLHPVAQAAIAHAQFESIHPFTDGNGRTGRALVAAVLRHRGATRTASPPVSSVLVAERTRYFQHLTQYREGHVDAWVRDVAIAVGAGSDEALVTGLLLDEVAADRAATTCAAGPHAVLGRALDQDAVLTEDHAEELLRRAIARGDVSGTAETLLETTVTDLCRAGVLRPVTARRRRRAWIAPAVAAELDAFAERVRAGVEARAHRVAW
>NZ_CP009755.1|WP_066657945.1|1112792_1114964_-|S9-family-peptidase
MSSEHAQATPPTAAKRPVTRTHHGIEFVDDYEWMRDKESPETLAHLEAENAWTEAQTEHLTGLRDRIFAEVKNRVQETDLSVPVRMGDWWYFTRTAEGSQYGVHCRAPITGPDDWTPPAVDEGATALPGEQVVLDGNALAEGHDFFSLGSYDISDDGTRLLYGVDVEGDERYTLHVRDLTTGTDLGDEIPDTGSGATFDPSGRYVFYPTVDESWRPDRIWRHTVGSATGDDVVVFEESDDRYWVGVGVTRSSQYIVIELGSKITSEALVLDAADPTGEFRVVWPRREGVEYEIEHAIVGGSDRFLVLHNDGAENFELVDVPADDPTSEHDRRVVVAHHTERRIESVDAFAGHLALEYRAEALPRVAVIPIEGDGYGDAHEVPFDEALFSAGLGGNPEWEQPTLRIGYTSFVTPSEVSDLDLATGEVTVLKRQPVLGGYDPADYVQERDWATAPDGTQVPISLVWRRDAVDADGPAPLHLYGYGSYEHSIDPGFSVMRLSLLDRGVVFAVAHVRGGGEMGRHWYEDGKTLTKKNTFTDFVAVAEHLIESGRTSADRLVAEGGSAGGLLMGAVANLAPERFAGILAAVPFVDALTSILDPDLPLTVIEWDEWGDPLHDAEVYRYMSEYSPYENVRDDVQYPRILAVTSINDTRVLYVEPAKWTAKLREVGAPVLLKTEMAAGHGGVSGRYDSWRERAFELAWLLEVLGLADVNPAAASAEPIAAG
>NZ_CP009755.1|WP_066653209.1|1111152_1112685_+|CYTH-domain-containing-protein
MTDTHLEIERTYDMPEGDDLPDLIGVGSIARTERQEPFGLDATYWDTERYDLVASRVTVRRRTGGPDAGWHIKRAASDTVRHEQHFALTDDPDTVPDEVLAALFAERRGRGLRPVVRITTTRAVVRLLDEDDDQVAELADDRVVAQRLDDHAPATPRTWREVEVEVAEGVDEQVAHELFAALDGRFADIDAHPAAVTSKLARGLEGAPAARLRTAEKPEKHTAARALTKRLRKLRSTLLALEGQLRAGAETDLRETARTSLDIAAVLGSYRPAFPATPATDRAAEAADALAAVTARAALADYLVERLPHASTPAQDLLVDAMTRERVLAATRERRAVAVGEVTAFLHSERYLELLDALDDAVERPAPTAWALRSPKHVAQDVSAVEKPRVRDLVRNAVGDDDESVGPVDREAADRAATETAWRAATRARAAMDVLGDDAFPHALWKRIGDAADVLTERVRSLHALDVLRVHSGIAERGGEGTFGYGVLAGDRVRLAEDSYDQAVQALNRV
>NZ_CP009755.1|WP_066653235.1|1125151_1126636_+|aspartate-ammonia-lyase
MTGNEAARTRTETDSLGSLEVPADAYWGINTLRALENFPITSVPIAVYPDLVEALATVKQAAARANKAIGVLDAERADAIDQAAQEVRDGSLRDQFVVDVVQGGAGTSTNMNTNEVLANRALEILGREKGDYAYLHPIDHVNRSQSTNDTYPTSIKLAMILGVRRLTEQLELLSDAFAERGRAFQDVLKVGRTQLQDAVPMTLGQEFTGFAHTIQEDVLLLRTVSPLLAETNLGATAIGTGITADPQYRDEVRRQLQVASGLDIVTAPDLIEATSDAGAFMTLSGTVKRSAAKLSKICNDLRLLASGPQAGLGEITLPARQAGSSIMPGKVNPVIPEVVNQIAFAVAGADTTVTMAAEGGQLQLNAFEPIITHSILQSLQWMASGCATLRVNCVTGIEANEAKLAAQVDTNVGVVTALTPYIGYAAAASIAHTALTTSTPIATLVTAAGLMDEDQVQRVLSPARLSGIELATGAIPIVTEEMLDAEAERVARER
>NZ_CP009755.1|WP_066653237.1|1126739_1127828_-|YihY/virulence-factor-BrkB-family-protein
MPDSASRDLQRTGVRAVVRRTYHSVIRHRVVDAAASLTFFALLTVFPAALAVVSALSVVDRQGDSLTDIIQVLGFIVRPETAQHLEGPLRQLLTLDNPWVGFSIGLVLTLWSLSGYATAFGRAMNTAYEVEEGRRIWKFRSMMLLVTLLVMVGGAIAIVILLGTPTISAAIVRQLGWAPWIDDLWNVAKWPVLAVVLVVMVAVLYYATPNVKTPQLRWVSAGAAFAIVTWAVATLGFSIYVETVGGSGNRAYGWLGGAILLLVYLYISNFVLVVGGELDSEVIRMRQLLAGIEADESIRLPLRDVTRNFTLARWRDQDIAAAHRVRLAAQQRAEDEHEEPSPTEEHLRAMSHQVRVGEPPLP
>NZ_CP009755.1|WP_081984746.1|1128004_1129321_-|MFS-transporter
MTRPDTEPRRRLLADLTPLRRSPAFARLWAGTAIAGIGTQMTTVAVGLEVYEITRSTFAVALVGVIALVPMIVAGLYGGMLADAFDRRLVALVSAIIAWAAVALIATHAWLGLHSVALLYVLATVNAVAATVSNASRSAIVPRLVGTDLLPAASALGGIASGFQVTVGPAIAGVLIASVGFAPTYTIDVVLFTFAFLGVFTLPRMAAEHDALRPGLRSLVEGARFLRRSRNITMTFVLDIVAMTFGQPRVLFPAIGALVIGGGSITVGTLTAAYAVGALLSSVFSGPLGHVRRQGEAVGWAITAYGAAIAAFGVVIAVAHLLGGRSGEAFGVEILPALGLAALFLAAAGGADNVSSVFRNTILQAASPDGMRGRLQGIFIVVVTGGPRLGDLYAGLVVAAGIAYPPIIGGVLIIGLVALLLRLVPSFRRYDALDPHAN
>NZ_CP009755.1|WP_058728797.1|1129534_1129906_+|peptidylprolyl-isomerase
MTDLNSKPEFDAPEGPAPTELVITDIVEGDGDVAQPGSTVKVHYAGVEYESGEEFDSSWNRGEPIDFPLAALVRGWQEGIPGMKVGGRRKLTVPPELAYGPAGGGHFLSGKTLIFIIDLLGVR
>NZ_CP009755.1|WP_066653239.1|1129905_1130742_+|aldo/keto-reductase
MQVGAPTIELNDGHRFPELGLGTYGLNGDEGTAAVGAAITSGYRLLDTALNYGNEDAVGRAVRESEVDREDLVVTSKLPGRHHGYDEAHRSIDETLGNLGLDRVDLYLIHWPNPSVGKFVDTWKAFVDLRDSGKVRSIGVSNFTPEHLKAIIDATGVAPAVNQVELHPYFPQAELRKVHAEYGIVTESWSPLAKQSELLTEQPVLDAAAAHGVTPGQVVLRWHVQLGAVPVPKSGDADRQRENLDVFGFALTDDEVRAISGLERGRLWDGDPDTHEEM
>NZ_CP009755.1|WP_066653241.1|1130906_1133153_+|ATP-binding-domain-containing-protein
MSEPTETDRERSYVDGLFTRLDELTAEAEQRLAETRRQAVGGNHQSRSERDAYARLYEDTIATLDRVGDRLVFGRLEVSEPESPDDTFRYIGRVGLRDVEHRPLLLDWRVPGASAFYQATAAHPMGMRARRHLTLEGRTVVNVEDEVFDATLYDDERTHLQGEGALLAAVTAERTGRMTDIVATIQGEQDRIIRSALEGVLIVQGGPGTGKTAVALHRAAYLLYTHRDRLRGSGVLMVGPSPAFLTYIEQVLPSLGETGVVMASLGSLYPGVHATMHDHGDVAAVKGSAQMASLLRRAVRSRQVVPTESVVLDVEGERLTVPPQLVADALKRAQDRGKPHNVARVTFNKIALDAMTRLLADQLRARGTTVDEADEKVLREDIRSSYDARVLLNTAWLPLPPEKFLEDLYARPNWLASLTPDWTPARRALLRRPRGAGFTIEDVPLLDEAAELLGPFDPTGGAAKRAAKASRNRDIENARQAIENMGVEGIVSAEQVAGSFAEGGDPRTTAERAAEDREWTYGHIVVDEAQELSPMQWRVLARRNPLRSFTIVGDMAQGSSPAAARTWDDVVGALARRRRGRAPVVPLDHRIAELTVNYRTPRSIVQAAGAFADAAGLAVTRTEAVRDGDPVDRVSVPRAALLDTVAEHVDAERERIGSGTIGVIVPEAELTAVRERLARTDADVRGLGSPRPGSVTVLTGADAKGLEFDGVLLVDPDRVGADAARAAAAVYVAMTRPTRRLVVVDVID
>NZ_CP009755.1|WP_066653244.1|1133142_1133421_-|hypothetical-protein
MQIVVRRSGGFAGLSRGWRIDTDSCDDPDAWDDLVGALPREAPARRRQAVPDDFTWTVSVARTTVTIPGSQLDGAWAALVARVRDEGEPISR
>NZ_CP009755.1|WP_066653246.1|1133438_1134491_-|M4-family-metallopeptidase
MTATRRHSVVPPYLLRAVAAASEHPRAASAARTALAEMDVVTAPKHEHRVRPQGISGSVDRSPQRTVTDARGTTTLPGTVVRREGDPDSGDAAVDEAYAGLGATHAFWLDVFGRVSIDGAGLPLDATVHYGQDYDNAYWDGRRMVFGDGDDEVFRRFTVALDVIGHELAHGVTQYTADLTYQGQSGALNESVSDVFGSLVAQYAAGQTADQATWLIGEGLFTDAVHGVALRSMRAPGTAYDDPVLGKDPQPATMADYVETTEDSGGVHLNSGIPNHAFFLAATTIGGYAWEGAGAVWWDALTSPETTEDIDFAGFARVTVDAAAARFGQGSTEHAAVEDAWRSVGVLTGP
>NZ_CP009755.1|WP_081984748.1|1134575_1135676_-|hypothetical-protein
MPEQGTRGRTRGSGRRQWAVLAVGAVVAVAVGGLVLSTVSGSDDGPDGTGTPGATTTRSNGVEPGRAIAERESAAAAFPGGLAHQPDQDGQAARRAAEARADGERATAEQIDVIADQPVATWLTNPSESVTRQVVRRVVRGAEQQHRTPVFVLYAIPDRDCGSYSAGGTAEDAYLPWVRSAVRAMAGSHAVVLVEPDSIAQIHVCERLGRERLRLLDRAVDELAGHGLTVYLDGGNEDRVPVTEMARWLRAAGVDRTQGFATNVSNFYRVDTERAYADRLADAIGGDPHFVIDVSRNGQGWRGTWCNPEGAGLGQAPHVTAGSTRLDALLWVKTPGLSDGTCNGGPAAGQWWESYALALVEHRQRD
>NZ_CP009755.1|WP_066653249.1|1135779_1136226_+|VanZ-family-protein
MFRKLLLLALTAGYAWVIWRMTLTPRVFTHAQDELVLHVIGWLQQLPHGAWFTYDRVEFLANIGMFVPVGMIAALWLPRRWWLLGAVVAVVLSVGIELAQARFLPYRVADPRDVLSNGLGGLLGATLVGLVRSLLPVPRRQRLRARPA

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Crispr_ID: NZ_CP009755_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009755_5

1347794-1347878

Orphan

Consensus_repeat	Method
TGCGCGCTCGACGGCCGGCCCAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009755_5

>merge|NZ_CP009755|5|1347794-1347878|CRISPRCasFinder
TGCGCGCTCGACGGCCGGCCCAGCGCGAAGCCGGTCCGGGACCTCGACCGTGACAGATGTTGCACGCTCGACGGCCGGCCCAGCG

>NZ_CP009755|5|5|1347794-1347878|CRISPRCasFinder
TGCGCGCTCGACGGCCGGCCCAGCG	CGAAGCCGGTCCGGGACCTCGACCGTGACAGATGT
TGCACGCTCGACGGCCGGCCCAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009755.1\|WP_066653698.1\|1345269_1345749_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NZ_CP009755.1\|WP_144411431.1\|1357140_1358484_+\|3-deoxy-7-phosphoheptulonate-synthase-class-II	unknown	unknown	gnl\|CDD\|366662
NZ_CP009755.1\|WP_066653699.1\|1345748_1346453_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133378
NZ_CP009755.1\|WP_066658035.1\|1358734_1360777_-\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP009755.1\|WP_066653693.1\|1341045_1343481_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|379305
NZ_CP009755.1\|WP_066653691.1\|1339430_1340411_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182463
NZ_CP009755.1\|WP_066653706.1\|1355235_1356189_+\|ROK-family-glucokinase	unknown	unknown	gnl\|CDD\|273246
NZ_CP009755.1\|WP_066653732.1\|1362317_1362683_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375793
NZ_CP009755.1\|WP_066653688.1\|1335413_1336571_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_058729211.1\|1347939_1348752_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113
NZ_CP009755.1\|WP_066658027.1\|1335016_1335238_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066653690.1\|1338381_1339434_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182464
NZ_CP009755.1\|WP_066653695.1\|1343480_1345079_+\|glycosyl-hydrolase-family-18	unknown	unknown	gnl\|CDD\|119360
NZ_CP009755.1\|WP_081984785.1\|1336665_1338192_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP009755.1\|WP_141718808.1\|1346688_1347213_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133380
NZ_CP009755.1\|WP_081984787.1\|1353154_1355068_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NZ_CP009755.1\|WP_066653701.1\|1352224_1352728_+\|peptide-deformylase	unknown	unknown	gnl\|CDD\|234668
NZ_CP009755.1\|WP_066653700.1\|1348812_1352223_+\|pyruvate-carboxylase	unknown	unknown	gnl\|CDD\|237263
NZ_CP009755.1\|WP_066653708.1\|1356230_1356953_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|153251
NZ_CP009755.1\|WP_066658038.1\|1360889_1362098_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|182727

Protein	Function_ID	Function_description	E-value
NZ_CP009755.1\|WP_066653698.1\|1345269_1345749_+\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	5.49568e-20
NZ_CP009755.1\|WP_144411431.1\|1357140_1358484_+\|3-deoxy-7-phosphoheptulonate-synthase-class-II	gnl\|CDD\|366662	pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.	0
NZ_CP009755.1\|WP_066653699.1\|1345748_1346453_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.6285e-15
NZ_CP009755.1\|WP_066658035.1\|1358734_1360777_-\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.43484e-118
NZ_CP009755.1\|WP_066653693.1\|1341045_1343481_+\|glycosyltransferase	gnl\|CDD\|379305	pfam13632, Glyco_trans_2_3, Glycosyl transferase family group 2. Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.	2.6604e-26
NZ_CP009755.1\|WP_066653691.1\|1339430_1340411_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182463	PRK10440, PRK10440, iron-enterobactin ABC transporter permease.	3.02448e-62
NZ_CP009755.1\|WP_066653706.1\|1355235_1356189_+\|ROK-family-glucokinase	gnl\|CDD\|273246	TIGR00744, Glucokinase_Glucose_kinase., ROK family protein (putative glucokinase). This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General].	8.08476e-75
NZ_CP009755.1\|WP_066653732.1\|1362317_1362683_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375793	pfam18367, Rv2175c_C, Rv2175c C-terminal domain of unknown function. This is the C-terminal domain of unknown function found in actinomycetes such as M. tuberculosis Rv2175c. Rv2175c has a DNA binding activity and possesses a winged helix-turn-helix fold, furthermore it is identified as a substrate of the PknL kinase.	7.49699e-19
NZ_CP009755.1\|WP_058729211.1\|1347939_1348752_-\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	1.33472e-42
NZ_CP009755.1\|WP_066658038.1\|1360889_1362098_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|182727	PRK10783, mltD, membrane-bound lytic murein transglycosylase D; Provisional.	7.04531e-14
NZ_CP009755.1\|WP_066653690.1\|1338381_1339434_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	9.86004e-82
NZ_CP009755.1\|WP_066653695.1\|1343480_1345079_+\|glycosyl-hydrolase-family-18	gnl\|CDD\|119360	cd06543, GH18_PF-ChiA-like, PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in archaea but also in eukaryotes and prokaryotes. PF-ChiA exhibits hydrolytic activity toward both colloidal and crystalline (beta/alpha) chitins at high temperature.	1.05545e-109
NZ_CP009755.1\|WP_081984785.1\|1336665_1338192_-\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.51369e-45
NZ_CP009755.1\|WP_141718808.1\|1346688_1347213_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133380	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators. Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	8.85509e-16
NZ_CP009755.1\|WP_081984787.1\|1353154_1355068_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NZ_CP009755.1\|WP_066653701.1\|1352224_1352728_+\|peptide-deformylase	gnl\|CDD\|234668	PRK00150, def, peptide deformylase; Reviewed.	1.9841e-51
NZ_CP009755.1\|WP_066653700.1\|1348812_1352223_+\|pyruvate-carboxylase	gnl\|CDD\|237263	PRK12999, PRK12999, pyruvate carboxylase; Reviewed.	0
NZ_CP009755.1\|WP_066653708.1\|1356230_1356953_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	6.98796e-51

>NZ_CP009755.1|WP_141718808.1|1346688_1347213_+|MerR-family-transcriptional-regulator
MTRYDLGLLFTDGLPEHDEQNGYRGTVAARAAGISYRQLDYWARTELVQPTIRGAAGSGSQRLYGFRDILVLKLVKRLLDTGISLQQIRTAVNQLRESGVSDLAQTTLMSDGASVYLCTSDDEVIDLVSRGQGVFGIAVGKVLREVESSLVELDATPAADPADELAARRANRAS
>NZ_CP009755.1|WP_066653699.1|1345748_1346453_+|MerR-family-transcriptional-regulator
MAARSAAARAGAAVPDLLTIGQVIARLKPDFPDLSSSKLRFLEERELVTPIRTASGYRKFSAADVERLRIVLGLQRDHYLPLKVIKDYLADLDAGREPVLPGGGDAPRPSILGRERRYTRDETVRAAGASPMLLTDAVSASLLPAADTYGDDAVAVLKALVELQRTGIEPRHLRTMRGVVEREVGLIESALMPVSRRGDATSRAKATELAREIAGQLEVVRSNLIRTAIGRLDA
>NZ_CP009755.1|WP_066653698.1|1345269_1345749_+|FHA-domain-containing-protein
MPEPVVPQPGGQKTPEQRLVDTTLTFSMDMGAALTAESGVSTEEREAINALPSGSALLVVRRGPNVGARFLLDSDVTTAGRHPAADIFLDDVTVSRKHAQFLRHGTAFSVKDNGSLNGTYFDGVRIDEALLTDGAEVQVGKFRLTFYASRVDLARLATA
>NZ_CP009755.1|WP_066653695.1|1343480_1345079_+|glycosyl-hydrolase-family-18
MSTTRRLSPVRVTIAVVVAAAVAVAGYAGFDRWHSAQATERQPAWFAAYTDVTATPVFAFEDVKSAKGRNVMLSFVVADHDDACSPTWGSYYSLQGAADQLDLDRRVARLQQQHGEVGVSFGGLANDELATTCTKASDLLGAYRQVVQRYDLSTVDFDVEGDDLTNRAAGERRAKAVAALQDERRAAGHPLAVWLTLPAAPSGLTSDGTTAVAQFLAAGVDLAGVNAMTMDYGEAKGSSQSMYSASVQALQEVQRQLGVLYQRAGTPLGDGTLWHKVGATPMIGQNDVRDEVFSLSDARKLNAWARDRGLGRMSMWSLNRDTTCGSNYVNLSTVSNSCSGVDQDGLLFADVLGKGFGGGIVAAASDVTEAEPSATEQPTDDPKTSPYPVWDQDASYLEGTKVVWHRNVYEAKWWTSGDLPDDPVLSAYETPWQIIGPVLPGEKPVEPLTLPDGTYAAWSGTKQYDTGARVLFHGIPYQSKWWNTGDSPEASTSDPDGSPWVRLKDAEVRRILDGLASGEPAPTATATATPAP
>NZ_CP009755.1|WP_066653693.1|1341045_1343481_+|glycosyltransferase
MPDPSAGAPTRRRQWGAERRTRPLDTLHARPSDRKLVSGRVAIILTVAFWLAYVVYTVIRQFLDYGTESFRFTTEAISYLVVVTFLTFSALMHLVARQGAMERFASHVRVPRAELDRHFASGHEAPMTVLVPSYAEEPDVVATTLWSAALQEYPSLRVVLLVDDAPFPTDPATLDKLERTRAVADRIQAQLEVPSRRFQEALFSAEVEADAAPFASTHALRTLVEHHRWADAWLRRNAREHEVADHVDRFFHDQVLVGLADEFRLTAEALEAAIADAVALGQDFSEVTSARALELQRRLAWTFTAELTTFERKRYVNLSDEANKAMNLNAYIGLMGGAYAFDETASGTVLRTVDDADAADLVVPASDYLLTLDADSVLLRDYCLRLVYFLEQPENARVAVTQTPYSSFRGAATRIERLAGATTDIQHILHQGMSRYDATFWVGANAVIRTQALRDIEEVETVGGFEVKRYVQDRTVIEDTESSVDLGMHGWTLVNYPERLSYSATPPDFGSLVVQRRRWANGGLLILPKYVRQVRERRARGERVGLVEMALRVNYMASITWASFGLVFLLAYPYDSRLLSPMVLLAALPYFWLLSSDLRYCGYKRTDVFRIYGFNLILTPVNVAGVLKSIQQALTAKKIPFARTPKVRDRTASPALYVLAPYAIVAFSVFTFVRDYGAQNWGNAVFAAFNALLATYAIVAYIGVWNSVVDVWLWATRWMYYDPSARAARRAARRTARAAARADRRRGRRRGGVRPVPEPVLEDWHAVLYFGHGGGNLPVRHDADVVGAAGARATASAQADATGPRQERSAA
>NZ_CP009755.1|WP_066653691.1|1339430_1340411_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTAVRRELAVLGAVVVLLVALVLVGLGVGEIPLSPLQVAGALVGHGDTVSDFVVGQLRGPRVAGAVLVGAALGAAGGIVQSVVRNPIASPDVIGITSGASASGLTAIVLFGASGGVLFGSVVVGALLVSVVIAALSWRRGITGNRVVLVGIGVAAICLSITGWMLTAGSVQQAGTALLWLSGSLNAVDRTLVGILAVAVVLLLAAALAQSRRLTVLALGDEVAAALGLRPDRAKSLLLLTAVGLTAGAVATAGPVAFVALMAAPIGRRLVGNGRVALGVVAAVGAVVTLASDLLAQFAIPGNALPVGVVTGVVGAPYLLWLLARGR
>NZ_CP009755.1|WP_066653690.1|1338381_1339434_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MRASSPVTPAVRPRPAPASRSRLVGAALLAVAALVVAVALSVAFGSRPIPLGTVLDVVLHPHRDDEVGLIVLGNRVPRTVVGLLAGAALGVAGAVMQGVTRNPLADPSILGINAGAALAVVVGIAVFGISGTAAYLPFAFVGAGLAALLVYGIAAVARRGLSPVGLALAGAVVAAALSSVTTAVLVSSQSLLDQLRFWQVGALAGKDLGTAGVVAVPVLVGLVVAAGLGRSLNTLALGDELAASLGQRVVLVRIVGGVVTVLLAGSAVAAAGPIAFVGLAVPHAVRRLSGPDQRWTILLSALVAPALLLVADVIGRVVAYPGELQVGIVTALIGAPVFIWLVRSRVVTGL
>NZ_CP009755.1|WP_081984785.1|1336665_1338192_-|PDZ-domain-containing-protein
MNENPADDQRATDRPGWEAPHADRDTLRPAYAFDGSGPWLYGTDGSGPYAYTPDGRGPYLLGSAALGGPTDPRPGTASTSTAAAGATAGSTPWGWTSGAAAANHPGAKRPRRLGLVIGSGVAALAIIGAAGGTALGLSSQGTTTTSSQSQGTTTLPGGGSGTSGGTNGFTVPGYGNGSGSDGSSGSGSGTGTGTGTGTQTAATPATAAQTKGVVTIDTVMNYDTSSQAAGTGMVLTSDGFVLTNNHVVQGATSIAVTDETTGKQYRAEVVGTDATHDVAVLKLQDASGLSTVTLDDDGEPSTGDAVTDVGNAEGTGNLVAAAGTVTALDQDIQVQSESGTGTESLQGLIEVAAQIVPGDSGGPVLDSEGEVVGMATAASSGSAEVTGYAIPITTAKAIADKILAGESSDTVTIGLPAFLGVEVGSTATTQTTAGVPVAGTVDGSGAAAAGLVAGDTITSLDGTAVTSNDALTSAIRSHAVGDRVQVGYTDASGTAHTVTVTLTAGPAA
>NZ_CP009755.1|WP_066653688.1|1335413_1336571_+|hypothetical-protein
MAVPVPLGTEDRTSRLTLRRPDRWHREDSPQADLRLTGDDVVLTVRSRPSERTVAEEHTSLLERLPGSVEGLRLIGCDPWTTAGAPARLVEYVRPDEDGDVAGAHLLFVTGRHRVDLTVERPLTRMLATDDLVSTVLESVRATEPAPSRPQRELEALPVAAPVPQLDGTHLGPDALTTLRSLAGRRWDPMLLRSPAGRELVQTGLVGRLGTLPETTQELLAPWADDTRPVTLEQRLPDGRTTRLQAWSETVVDGTDETGGTVARLPVERVVGLAAGRLGIRPSWTFPFRTGSLHANLLARRTGAADTAPDLPVAVAEADPRLARFWAAPWTVSSIRRPGRPAPVVVVHAEGIGFARVGRTEAGETAFRSDSPANVYRSVVRALLG
>NZ_CP009755.1|WP_066658027.1|1335016_1335238_+|hypothetical-protein
MALGVLRAASPGDRLVVRARVGDGARDALGTLSARTVDTVTIETRRGHVDVPLADVVAAKHVPPPPTPRTRRP
>NZ_CP009755.1|WP_058729211.1|1347939_1348752_-|ParA-family-protein
MHVLSVSSLKGGVGKTTVTLGLTSAAFAKGLRTLVVDLDPQSDVSTGLDIDISGHLNVADVLENPKEKIVRQAIAPSGWTKGSQGKVDVLVGSPSAINFDGPHPSIRDIWKLEEALANVEQDYELVLIDCAPSLNALTRTAWAASDRVTVVTEPGLFSVAAADRALRAIEEIRRGLSPRLQPLGIIVNRARVQSLEHQFRIKELRDMFGPLVLSPQLPERTSLQQAQGAAKPLHVWPGESAQEMAKNFDQLLERIMRTGKIGPYAEGGAA
>NZ_CP009755.1|WP_066653700.1|1348812_1352223_+|pyruvate-carboxylase
MFSKILVANRGEIAIRAFRAAYELGARTVAVYPYEDRGSLHRLKADEAYVIGEPGHPVRAYLDVSEIIRVARESGADAIYPGYGFLSENPELAAAAAAAGITFIGPGEHVLEMAGNKVTAKEHAIAAGVPVLASTPPSRDVDELLAGADAVGFPVFAKAVAGGGGRGMRRVETKAELREALEAAMREADSAFGDPTMFLEQAVLRPRHIEVQILADATGTDDGTIHLFERDCSVQRRHQKVVEIAPAPDLDPAIAAALHRDAVAFARSIGYVNAGTVEFLLDTEGERAGQHVFIEMNPRIQVEHTVTEEVTDVDLVQSQMRIAAGETLADLGLAQDTVAVHGAALQTRITTEDPTQGFRPDTGRITTYRSPGGAGVRLDGGTVATGAQISPHFDSMLAKMTCRGRDFPAAVARAKRALAEFRIRGVSTNIPFLQAVLDDPDFARGDVSTQFIEERPQLFGGHVSKDRGTKVLGWLADVTVNKPNGERRPQTVEPVEKLPAVDLSAAPPSGQRDLLLQVGPAEWARRLRAQTALAVTETTMRDAHQSLLATRVRTKDLVAVAPHVARLTPQLLSVEAWGGATYDVALRFLGEDPWERLAALRGAIPNIPVQMLLRGRNTVGYTPYPTEVTDAFVAEAAASGVDVFRVFDALNDVSQLRPALEAVLATGTAVAEAALCYSGDLLDPAEDLYTLDYYLRLAEQMVEAGAHVIGIKDMAGLLRAGAAERLVGALRERFDQPVHVHTHDTAGGQLATLLAASRAGADAVDVAAAPMAGTTSQPSMSALVAALAHTERDTGLDLTAVGALEPYWEAVRRAYAPFESGLPGPTGRVYQHEIPGGQLSNLRQQAIALGLGDRFEQVEDWYAAANRILGRPTKVTPSSKVVGDLALQLAAVGADPDDFEQNPQQYDIPDSVIGFMAGELGDLPGGWPEPFRSKVLEGREVHVGTTPVPEAERAALATAGPERQQALNRLLFPQPTRQFAAVREQYGDLSVLPTLDYLYGLRPGQEHVVPLGRGVELLVGLEAIGEVDERGVRTVMTTLNGQLRPVAVRDRSVEVATKVAEQADPSDPKHVAAPFSGVVTLKVAVGDVVRAGQPVASIEAMKMEAAITAPVSGTVGRLAIPVTQQVDAGDLLVVLQ
>NZ_CP009755.1|WP_066653701.1|1352224_1352728_+|peptide-deformylase
MTVRPIRLFGDPVLRSPADPIAPDALGSPGVRDLVQDLLDTVREPGRAGVAAPQIGVGLRAFSYNVDGEVGYVLNPEVVEVRGEVELMDEGCLSVPGLSYPTPRHPWARVRGVDVDGAEVVLEGTGLMAEALQHEVDHLDGTVYVMTLAPEVRRAALRDVRAQSWFH
>NZ_CP009755.1|WP_081984787.1|1353154_1355068_-|long-chain-fatty-acid--CoA-ligase
MLAVTSHRRGVLVSHRPTRESTVNDQRQPAPNSAPDHGSAARLLSDRARRTPDRPILAQRHGDTWTTVSAADTLARVRGIAKGFVAAGLAPGAHVAVLSRTRMEWTLVDFAVWTAGLVSVPVYETSSPDQVRWILSDSETVAIVVEQEEHARRVASIAPDLPHLGQHWTIDGGGLDDLVRLGETVTDAELDARTADVHGHDDATIIYTSGTTGRPKGCVLRHDNFTGTVEGATEAMPEVVADGSSTLLFIPMAHVFARFIAVMSISTGVLVGHEPDTRDLMRAVSTFKPTFLLAVPRVFEKIYNSAEQKADLGGKGRIFRAAADVAVAHSEAVAAGRVPLGLKLRFALFDKLVYAKLRDAIGGRVQYAISGSAPLSPRLSHFFRSIGVHILEGYGLTETTAPATVNRARELRIGTVGRALPGVEVRIAEDGEILIRGVDVFDRYWHNDEATAKAFSDGWFRTGDLGRLDADGVLTVTGRAKELIVTASGKNVAPAPLEDGIREHPLVGQVVVVGEGKPFVAALVTLDREMLPGWCEARGITPALTPREAAYDERVHVAVQEAVDTANQRVSRAESVRSFTIVDTELTEASGHLTPKLTIKRAVVLRDFAADVEHIYSGSKVQTTATPVVASRRRGRA
>NZ_CP009755.1|WP_066653706.1|1355235_1356189_+|ROK-family-glucokinase
MHAIGIDIGGTKIAGAVVSELGEILAEDRVATNAADPDAMLDDVVTMVTRLRAAHDVGAVGVAAPGFIDASQSIVYYTPNIRWRNEPLRQKLQERLGDLHITVDNDANAAGWAEFRFGAGRLVSDMTMLTIGTGVGGAIVTEDRLFRGGFGTGGEIGHLRIVPNGLPCGCGARGCIEQYGSGRALQRMANDVADAGGIGSALADAREQNGGQLDGAIVGDLILADDPGALAALRRLGRHLGEACASLSAVLDPQLFVFGGGVASAGDRLLEPIKQAYLNNLPARGYHPEPDFVIAELVNDAGVVGAADLARIHARTA
>NZ_CP009755.1|WP_066653708.1|1356230_1356953_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MTYWLLKNFLLGPLILTLFRPWVVGREHVPAKGPVIFASNHISFIDSVILPAVLDRRISFLAKSDYFTGRGLKGWATKTFFNAIGQLPIDRSGGKASEASLHTGLQVLARGEQLGIYPEGTRSPDGKLYRGRTGIARMILEGRVTVVPVAMVGTREVQQIGQKFPKFKRVGVVFGRPLDFSRFEGFETDRFILRSVTDEVMHELAGLSRQEYVDVYATSVKERASSAREQVMKDRRTPTA
>NZ_CP009755.1|WP_144411431.1|1357140_1358484_+|3-deoxy-7-phosphoheptulonate-synthase-class-II
MIEGLDHWRTLPIKQQPTWPDRAAAEAASAEIATLPPLVFAGEVDKLRDRLAAAAQGRAFLLQGGDCAETFAGATADSIRDRVKTILQMAVVLTYGASTPVIKMGRMAGQFAKPRSSDFETRGDVTLPAYRGDIVNGYDFTPESRQADPRRLVQGYHTAASTLNLVRAFTQGGFADLRQVHSWNKGFASNPANARYEHLAKEIDRAIRFMDACGADFEALKHTEFYASHEGLLMDYERPMTRIDSRSGLAYDTSGHFIWIGERTRDLDGAHVDFLSRVRNPIGVKLGPTTTVDDMKALVDTLDPEREPGRLTFITRMGAGRIRDELPKLLEAIKGMDANPLWVTDPMHGNGLTTPTGYKTRRFDDVVDEVLGFFEAHRQVGTYPGGMHVELTGDDVTECLGGSEQIDEATLATRYESLCDPRLNHMQSLELAFLVAEELSAHPYQRP
>NZ_CP009755.1|WP_066658035.1|1358734_1360777_-|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MTTNAATDPMIGRMIDQRYRVRSRIARGGMATVYLATDVRLERRVAIKIMHGHLADDQAFRERFIQEARSAARLSHPNLVGVYDQGAEDDTAYIVMEYIPGITLRDLLQEHRALTPEQATDILRAVLAGLASAHRAGIVHRDLKPENVLLADDGRIKLGDFGLARATTANTATGAALLGTIAYLSPELVTRGAADSRSDIYALGIMLYEMLTGEQPYKGDQPMQIAYQHANDTVPVPSAAEPGVPPELDDLVAWATARDPADRPRDAREMLDHMSGNQQRATGQYRTAVLRPENATAILPAGSASPSSADASGRWDGPEQDDATRVIADTTGGAPAAPARRGAPGPRRTGTQPGTLSPAAQRLADKSVKRRKRGWILLAVVVVLAIIAGVVGWALGPGPWGNVRIPEVAGKSVAQARQLLQAQGLQPTAETDSRYDAVVAKGQVSTTKPAAEREVRKGTPVRIVVSDGPRMIALPAIVGQPLSTVTAALDDDFQLQDDQYEFSADAPEDTVIAAKGLGTDGQTVDLSSVGEYAERGPVTLTVSLGAVPDVTGKTLDGATAALDAVGLVVGAQQERYSDDVPKGQVISSSVEDSPAVQGSAVDLVLSKGPTPITLPDVAGKTIDEATSTLENLGLDVKVPDCTNVLCRFYDWKSALPVTATDPVQGSTVYRGDTITLSYEQ
>NZ_CP009755.1|WP_066658038.1|1360889_1362098_-|LysM-peptidoglycan-binding-domain-containing-protein
MPIVLAGTIAVTAGLTGPVAHAEPRHDDAAKKRHVDEDRNVGQRPVFGTAVARPSTTTVTTVAAVSKAPTTYTVRQGDTVSGIAARFGLSAQEVLVRNGLGWNTIIHPGQTLHLSSTPAAPAAAPATSSTSGSYHVKSGDTVSGIAARVGVSTSAILAANNLSQRSLIYPGQTLTIPRAGTAPAAKPAPAVSTAPAAPARASSVKIVAGDTIGAIAAKHGVSVKALLAANGLSYTSTIYAGKTLVLPAATSKPTTTPTGGAVTTAVGSVNGVELTGEQRRNAATIVSVGRTLGVPDRGIVIALAAALQESSLRNLSHGDRDSVGLFQQRPSQGWGTAAALQDPATAAELFFVGNPGKTRGLLGVRGWSSMALTDAAQAVQVSAYPNEYAKWEQTARALLASL
>NZ_CP009755.1|WP_066653732.1|1362317_1362683_+|helix-turn-helix-domain-containing-protein
MGRVSDGPTDDTTLSERWLTVPDLVDLLGVSPGRIHRLFEQKTLLAARVGGVLRVPSEFFDGSEPMPELRGTLIVLGDNGFSDDEAVRWMLSEEPALRTSPIAALRAGRKAEVRRVAQSLL

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Crispr_ID: NZ_CP009755_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009755_6

1825673-1825783

Orphan

Consensus_repeat	Method
GCGACATTCCCGTCGTCGTACGACAGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009755_6

>merge|NZ_CP009755|6|1825673-1825783|CRISPRCasFinder
GCGACATTCCCGTCGTCGTACGACAGCGGCATCGTCGCAGGGCGCACGCGCATCGTGCAGCCCACGTCGCCGGCGGACAGCCGCGACATCCCCGTCGTCGTACGACAGCGG

>NZ_CP009755|6|6|1825673-1825783|CRISPRCasFinder
GCGACATTCCCGTCGTCGTACGACAGCGG	CATCGTCGCAGGGCGCACGCGCATCGTGCAGCCCACGTCGCCGGCGGACAGCC
GCGACATCCCCGTCGTCGTACGACAGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009755.1\|WP_081984869.1\|1816229_1817189_+\|SURF1-family-protein	unknown	unknown	gnl\|CDD\|119401
NZ_CP009755.1\|WP_022902786.1\|1819890_1820220_-\|metal-sulfur-cluster-assembly-factor	unknown	unknown	gnl\|CDD\|225062
NZ_CP009755.1\|WP_066654406.1\|1820219_1820987_-\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_CP009755.1\|WP_066654425.1\|1834485_1834845_-\|RNA-polymerase-binding-protein-RbpA	unknown	unknown	gnl\|CDD\|379162
NZ_CP009755.1\|WP_066654423.1\|1833420_1834191_+\|6-phosphogluconolactonase	unknown	unknown	gnl\|CDD\|376480
NZ_CP009755.1\|WP_066654415.1\|1827280_1829374_+\|transketolase	unknown	unknown	gnl\|CDD\|223100
NZ_CP009755.1\|WP_081984874.1\|1824379_1825366_+\|heme-A-synthase	unknown	unknown	gnl\|CDD\|224528
NZ_CP009755.1\|WP_066654411.1\|1825962_1826907_-\|protoheme-IX-farnesyltransferase	unknown	unknown	gnl\|CDD\|235293
NZ_CP009755.1\|WP_058727797.1\|1834848_1835100_-\|preprotein-translocase-subunit-SecG	unknown	unknown	gnl\|CDD\|235881
NZ_CP009755.1\|WP_066654421.1\|1832369_1833314_+\|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA	unknown	unknown	gnl\|CDD\|378404
NZ_CP009755.1\|WP_066654402.1\|1819038_1819638_+\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|376871
NZ_CP009755.1\|WP_066654410.1\|1822710_1824129_-\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_CP009755.1\|WP_066654426.1\|1835220_1836000_-\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NZ_CP009755.1\|WP_066654419.1\|1830834_1832373_+\|glucose-6-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|235579
NZ_CP009755.1\|WP_066654427.1\|1836043_1837261_-\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NZ_CP009755.1\|WP_066654400.1\|1817323_1818922_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP009755.1\|WP_066654417.1\|1829530_1830643_+\|transaldolase	unknown	unknown	gnl\|CDD\|235117
NZ_CP009755.1\|WP_081984867.1\|1815433_1815925_+\|DUF3099-domain-containing-protein	unknown	unknown	gnl\|CDD\|378630
NZ_CP009755.1\|WP_081984872.1\|1821375_1822710_-\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|376550
NZ_CP009755.1\|WP_081984870.1\|1821049_1821376_-\|non-heme-iron-oxygenase-ferredoxin-subunit	unknown	unknown	gnl\|CDD\|239604

Protein	Function_ID	Function_description	E-value
NZ_CP009755.1\|WP_081984869.1\|1816229_1817189_+\|SURF1-family-protein	gnl\|CDD\|119401	cd06662, SURF1, SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.	4.37345e-47
NZ_CP009755.1\|WP_022902786.1\|1819890_1820220_-\|metal-sulfur-cluster-assembly-factor	gnl\|CDD\|225062	COG2151, PaaD, Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only].	9.32254e-31
NZ_CP009755.1\|WP_066654406.1\|1820219_1820987_-\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	4.38185e-139
NZ_CP009755.1\|WP_066654425.1\|1834485_1834845_-\|RNA-polymerase-binding-protein-RbpA	gnl\|CDD\|379162	pfam13397, RbpA, RNA polymerase-binding protein. RbpA is a family bacterial RNA polymerase-binding proteins. RbpA acts as a transcription factor by binding to the sigma subunit of RNA polymerase.	7.36515e-43
NZ_CP009755.1\|WP_066654423.1\|1833420_1834191_+\|6-phosphogluconolactonase	gnl\|CDD\|376480	pfam01182, Glucosamine_iso, Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase.	2.90325e-82
NZ_CP009755.1\|WP_066654415.1\|1827280_1829374_+\|transketolase	gnl\|CDD\|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NZ_CP009755.1\|WP_081984874.1\|1824379_1825366_+\|heme-A-synthase	gnl\|CDD\|224528	COG1612, CtaA, Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones].	6.32141e-27
NZ_CP009755.1\|WP_066654411.1\|1825962_1826907_-\|protoheme-IX-farnesyltransferase	gnl\|CDD\|235293	PRK04375, PRK04375, protoheme IX farnesyltransferase; Provisional.	3.59117e-143
NZ_CP009755.1\|WP_058727797.1\|1834848_1835100_-\|preprotein-translocase-subunit-SecG	gnl\|CDD\|235881	PRK06870, secG, preprotein translocase subunit SecG; Reviewed.	1.46044e-10
NZ_CP009755.1\|WP_066654421.1\|1832369_1833314_+\|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA	gnl\|CDD\|378404	pfam10128, OpcA_G6PD_assem, Glucose-6-phosphate dehydrogenase subunit. Members of this family are found in various prokaryotic OpcA and glucose-6-phosphate dehydrogenase proteins. The exact function of the domain is, as yet, unknown.	6.65482e-89
NZ_CP009755.1\|WP_066654402.1\|1819038_1819638_+\|biotin-transporter-BioY	gnl\|CDD\|376871	pfam02632, BioY, BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes.	3.08552e-31
NZ_CP009755.1\|WP_066654410.1\|1822710_1824129_-\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP009755.1\|WP_066654426.1\|1835220_1836000_-\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	4.43379e-121
NZ_CP009755.1\|WP_066654419.1\|1830834_1832373_+\|glucose-6-phosphate-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0
NZ_CP009755.1\|WP_066654427.1\|1836043_1837261_-\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NZ_CP009755.1\|WP_066654400.1\|1817323_1818922_-\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.60096e-172
NZ_CP009755.1\|WP_066654417.1\|1829530_1830643_+\|transaldolase	gnl\|CDD\|235117	PRK03343, PRK03343, transaldolase; Validated.	0
NZ_CP009755.1\|WP_081984867.1\|1815433_1815925_+\|DUF3099-domain-containing-protein	gnl\|CDD\|378630	pfam11298, DUF3099, Protein of unknown function (DUF3099). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	2.92559e-23
NZ_CP009755.1\|WP_081984872.1\|1821375_1822710_-\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|376550	pfam01458, UPF0051, Uncharacterized protein family (UPF0051).	1.33454e-83
NZ_CP009755.1\|WP_081984870.1\|1821049_1821376_-\|non-heme-iron-oxygenase-ferredoxin-subunit	gnl\|CDD\|239604	cd03528, Rieske_RO_ferredoxin, Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable microorganisms to tolerate and even exclusively utilize aromatic compounds for growth. ROs consist of two or three components: reductase, oxygenase, and ferredoxin (in some cases) components. The ferredoxin component contains either a plant-type or Rieske-type [2Fe-2S] cluster. The Rieske ferredoxin component in this family carries an electron from the RO reductase component to the terminal RO oxygenase component. BPDO degrades biphenyls and polychlorinated biphenyls. BPDO ferredoxin (BphF) has structural features consistent with a minimal and perhaps archetypical Rieske protein in that the insertions that give other Rieske proteins unique structural features are missing. CARDO catalyzes dihydroxylation at the C1 and C9a positions of carbazole. Rieske ferredoxins are found as subunits of membrane oxidase complexes, cis-dihydrodiol-forming aromatic dioxygenases, bacterial assimilatory nitrite reductases, and arsenite oxidase. Rieske ferredoxins are also found as soluble electron carriers in bacterial dioxygenase and monooxygenase complexes.	4.87711e-38

>NZ_CP009755.1|WP_081984874.1|1824379_1825366_+|heme-A-synthase
MTRVGPTVEQGVRPGTRTPRWWSLPRAVDPRVIWLAWASFVVEVVLIGTGGLVRLTASGLGCPTWPKCTAESLVSTPEMGIHGVIEFGNRLLTFVLVVVAVAMFLAVVRMRRTRPELFWLAFAQGIAIPVQAVIGGLSVLTNLNPFVVGLHFVVSTTLVTVTATLVYRSMNGPRTAVRLVPGWYTGLVRGTVVAVVVTVLVGILTTGSGPHAGASEAVDGGRLHRTGFDPQLMEHLHAIPAYALFALTLALVVGAVVLRLSSRWALVLLVVEFVQIAVGLTQARTGLPVGLVGTHMVLAGLLVGAVTVVVLSTRGSAGRQAARERITA
>NZ_CP009755.1|WP_066654410.1|1822710_1824129_-|Fe-S-cluster-assembly-protein-SufB
MSDVLIDRPELEGLGQYEFGWSDSDTAGASARRGLSDEVVSDISARKNEPEWMHKLRLKALTLFDRKPMPSWGADLSDIDFDNIKYFVKSTEKQAQTWEELPEDIRNTYERLGIPEAERQRLVAGVAAQYESEVVYHQIREDLEQQGVIFMDTDTALREHPEFFEEYFGSVIPAGDNKFAALNTAVWSGGSFVYVPKGVHVEIPLQAYFRINTENMGQFERTLIIADEDSYVHYIEGCTAPIYKSDSLHSAVVEIIVKKNARVRYTTIQNWSSNVYNLVTKRAIAHEGATMEWIDGNIGSKVTMKYPSIYLAGEHAKGETLSVAFAGPGQHQDAGAKMIHMAPYTTSSIVSKSIARGGGRAGYRGEVRVDPAAHHAANTVRCDALLVDTVSRSDTYPAIDIRVDDVQLGHEATVSRVSEEQLFYLMSRGMPEDEAMAMIVRGFIEPIARELPMEYALELNKLIEMSMEGSVG
>NZ_CP009755.1|WP_081984872.1|1821375_1822710_-|Fe-S-cluster-assembly-protein-SufD
MSNTSTNPTPTDGATPAPRIDQPVEPSAVAQGQQAPSARSTQGTDQHGARAHSDGGWDAKVPVQTRSERPQSGDLDAFPPVTGREVNWKFAPLAKLQPLLEGGLDGSAYPFLARQTEGADVEWGRSDDPVVGTAGLPEDRAAAAAWTARDAVLKVTVKATEAHESISITRSDFGTQARAAHTVITAEQHAQGIVVIDNRGSALLSENVEIVVRDGARLTVVSLQDWDDDAVHVSTQFAEVGRDAFLKHVVVSLGGDVVRVNPSTHLGAQGADTEMYGVYFADAGQYIEQQVYVNHDAPNTRGRVNYKGALQGEGAHTVWIGDVLIGRAGDGTDSYEQNRNLVLTDGTRADSIPNLEIETGNIEGAGHASATGRFDDEQLFYLQARGIPEEEARRLVVLGFLVEVIQKIGAPELEERLIAAVEQELADGRTAVAAAEPEAEQADA
>NZ_CP009755.1|WP_081984870.1|1821049_1821376_-|non-heme-iron-oxygenase-ferredoxin-subunit
MAEKVCAESEIAVDSPMRVVVDGTAVAIVKDSAGAVHAIGDTCTHGDISLAEGFVEGDTLECWAHGSRFSLATGKPQNFPAYEPVPVFRVEVRDGDVYVDVHDPVPVD
>NZ_CP009755.1|WP_066654406.1|1820219_1820987_-|Fe-S-cluster-assembly-ATPase-SufC
MSTLEIRDLQVSIDTDQGTKEILKGVDLTINEGEIHAIMGPNGSGKSTLAYTIAGHPRYNVTGGSITLDGEDVLAMSVDERARAGMFLAMQYPVEIPGVTVSNFLRTAKTAIDGEAPALRGWVKDLRQSMADLKMDSSFAERNVNEGFSGGEKKRHEIMQLELLKPKFAVLDETDSGLDVDALKIVSEGVNRAKAATGLGVLLITHYTRILRYIKPDFVHVFVAGKVAEQGGPELAERLENEGYDRYVQAAAAGN
>NZ_CP009755.1|WP_022902786.1|1819890_1820220_-|metal-sulfur-cluster-assembly-factor
MITALSPEKFDEVVEGLKEVQDPELGVNIVDLGLIYDLAMDDEANALVISMTLTSAGCPLTDVIEGDTANALDGIVDAFRINWVWMPPWGPERITDDGREMMRALGFSI
>NZ_CP009755.1|WP_066654402.1|1819038_1819638_+|biotin-transporter-BioY
MTNATGFARRAVLADRLRTSGLATDAALVAGGALFTAAMAQLQVPMWPVPITGQTLAVVLVGATLGARRGMLSLLVYAVAGLAGAPFFAEFSGGLAALASPSFGYVIGFVPAAGLVGWLARRNWDRKVGRATVAMLLATAVPFVTGLPWLAVVLGQLGAPNDLQSVLAAGLYPFIVGGVAKALIAAGVLPLAWKLVGRR
>NZ_CP009755.1|WP_066654400.1|1817323_1818922_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MLAVHDLEIRVGARLLMEHVSFRVEKGDKIGLVGRNGAGKTTMTKALAGESQPTDGKIERSGEIGYLPQDPRSGNPEDTARKRILDARGLGELVEGIRQATLDMASDDADVAEKAMRRYSRLDDQFNALGGYAAEAEAASIASNLKLPDRILDQQLKTLSGGQRRRIELARILFSDAETMILDEPTNHLDADSVVWLREHLKTYPGGVIIISHDVELVDEVVNRVFYLDANRQTIDVYNMGWKLYQRQRVADEERRRKERAGAEKKAATLKDQAARFGAKASKAAAAHQMVARADKLLAGLEDERVADRVAKIRFPTPAPCGRTPLMAEGLSKSYGSLEIFAGVDLAIDRGSRVVILGFNGAGKTTLLRILAGADRPDTGEILPGHGLRIGYYAQEHENIDVNRTVIENMVSASTDLNETEARRVLGSFLFTGDDGYKKAGVLSGGEKTRLSLAMIVVSGANVLLLDEPTNNLDPASREEILNALAGFEGAVVLVSHDAGAVDALNPERVLLLPDGTEDHWNKDYAELIELA
>NZ_CP009755.1|WP_081984869.1|1816229_1817189_+|SURF1-family-protein
MTDEFDPSARYGRKHAAKLQRDAAPGSVHADTTDGPTVGWRFVRSRRWLGYFAIAVAFAIICTLFGMWQWDRRNEAVRQNEQIAQNYDHTPVPLDQALPRASSWTDDQQWLRVEVTGRYDVDDQLLVRNRVHNGQPGFEVLTPLVTADGRAFVVDRGWVPTGNRQDAPDSVPAPPSGQVTVIARLQQSEPRIPGRTDPSHTDQVQSVTLADVAGKVDAPIWTGAYGQLASESPAPAEARPLGWDRPSADTGLHLSYFIQWFLFAAGGFGFLAYVMVQEYRNLNQDDPEERERALERQRRKDAKPRSDDEVEDELLGAHR
>NZ_CP009755.1|WP_081984867.1|1815433_1815925_+|DUF3099-domain-containing-protein
MEEHRMKSTQRRFHATHTHSGSTQSITSLPDSPELDRAHRLSKYVWQMGVRVVCFIGAVLVWTTWHTWLAVIPIVLAAVIPWVAVILANAGNHAESDIVAPAGAIELYDAVDPRLREQQEDARAEAYRAEQERLREQAQHAQEEWQRNGDRSRVWSAKSRTRR
>NZ_CP009755.1|WP_066654411.1|1825962_1826907_-|protoheme-IX-farnesyltransferase
MTATATRPDTDRPRSTLSRKVRAYVSLTKPRVMELLLVTTAPTMFLAERGVPDLWLVFWTMLGGAMSAGSASAFNCYIDRDIDRLMKRTSQRPLVTGELSDKEALVFSWTLAVLSTAVLGFLVNWLAAALSVVAILIYVCVYTLWLKRRTPQNIVWGGSAGCMPVLIGWAGVTGSLTWAPIILFMVIFLWTPPHYWPLSMKYRDDYDAADVPMLAVVRGRTVVGLQVVLYAWATLVCSLLLIPVAHMGPLYTVVALAGGIWFVVESHRLYSRAIQHVEQVQPMRVFHSSITYLTLLFIAVGIDPLLPQVFTFTI
>NZ_CP009755.1|WP_066654415.1|1827280_1829374_+|transketolase
MAEFTWDAIDRKAVDTARVLAADAVEAAGNGHPGTAMSLAPVAHLLFQKVMRRDPSDSTWIGRDRFILSAGHASILQYVQFYLHGYGLELEDLQHLRKWGSKTPGHPEYGHTDGVEITTGPLGQGLASAVGFGYAQRFERGLFDPETADGESPFDHFTYVIAGDGDMQEGVTNEAASLAGRQQLGRLVVFYDSNQISIEDDTDIAFSEDVAARYEALGWHVQHVDWKKTGEYSEDVEELHRAVEAAKAETTKPSLIVLKTIIGWPSPTKQNSGKIHGSALGADELKGLKEVLGFDADKTFHVDPEVLEYTRGAITKGQAEHAEWTKIFDAWAAANPEKKAMLDRINAGELPEGLEEALPVFSTEKAVSTRAASGKVINAIAPLMPEFWGGSADLAESNLTTIEGAKSFGPAEASTKTWSTDPYGRVLHFGIREHAMGSILSGIVLHGNTRPFGGTFLIFSDYMRPAVRLAALMKAPAIYVWTHDSIALGEDGPTHQPIEQITALRAIPGLDVVRPADANEVSYAWLEMLKHKDRPAGIALSRQNLPVFERGEGDASGETLASAKNVAKGAYVLAEAPNGTPDVILIATGSEVQIAVDAREQLKGEGINARVVSAPSLEWFFEQSESYREQVLPKAVTARVSVEAGIAMSWRDIVGDKGRSVSIEHFGASADYQRLFAEFGFTTEHVVAAAKESIAAS
>NZ_CP009755.1|WP_066654417.1|1829530_1830643_+|transaldolase
MAENTPTAALSEVGVSIWLDDLSRELLETGKLTELIEQKNVVGVTTNPTIFASALAKGERYDSQVKELAAKGTDVTEAIFEITTQDVANASDVFKPIYDETKGFDGRVSIEVEPGLAHDTQKTIEQAKFLFEKVGRENVLIKIPATLEGLEAITEVIGAGISVNVTLIFSLERYRAVIDAYLGGLEKAKAAGHDLSKIHSVASFFVSRVDSEIDKRLDAAGTDEAKALKSKAGIANAQLAYQVWTEQFATERALGLLESGANTQRPLWASTGVKDPSLPDTLYVTELAAPNTVNTMPGKTLDATFDHGEIHGDAIAGSFDDAQQVMDQIAAAGVDYDDVVALLEKEGVDKFNVSWGELVDTVKTALENSK
>NZ_CP009755.1|WP_066654419.1|1830834_1832373_+|glucose-6-phosphate-dehydrogenase
MSPVAITPEHNPLRLPTDRRLNRIAGPSTLIIFGVTGDLSRKKLMPAVYDLANRGLLPPGFALVGFARRDWEDQDFSQLVHDAVRDHSRTPFDEAVWKQLEQGIRFVQGSFDDPEAFLELKRTVDELDAERGTLGNHAFYLSIPPKMFPVVTEQLKVSGLTEKREGSWSRVVVEKPFGSDLRTARELNAIVESVFAPDDVFRIDHYLGKETVQNLLTLRFANQMYEPIWNSNYVDHVQITMAEDIGVAGRAAYYDGIGAARDVIQNHLLQLLALTAMEEPVSFKAADLRAEKEKVLSAVRLPEDLATATARGQYDGGWQGGEKVLGFLEEAGMDPESTTETYAAIKLDIATRRWQGVPFYLRAGKRLGRRVTEIAIVFKRVPEDVYGNTQAPLGQNALVIRVQPDEGVTLRFGSKVPGVGTQVRDVTMDFGYGHAFTEASPEAYERLILDVLLGDPPLFPRHQEVELSWKILDPIEEFWATQGQPEQYRPGTWGPASADALLARDGRTWRRP
>NZ_CP009755.1|WP_066654421.1|1832369_1833314_+|glucose-6-phosphate-dehydrogenase-assembly-protein-OpcA
MKIDLPNTTVSKIQKKLVHIREEGGAVALGRVLTLIISTALGHEEEAISAANQASREHPMRVIIVSKNDGDTKSPGRLDAQIRVGSDAGASEVIVLRAYGETATDEESLVTGLLLSDAPVVAWWPQAAPEQPAASALGRIAQRRITDAAAQKDPNSAIEALGKSYVPGDTDFAWTRLTLWRNQLAAALDQPPYEPVTGVEVSGASDSPSTILLAAWLQLQLQVPVSVVTSPRATGSSGIHGVKLERASGTIDLERSLVDVATLSMPGQPTHDLSLPRRNLRDCLAEELRRLDADVLFGDVVKHGVPQLRESIAG
>NZ_CP009755.1|WP_066654423.1|1833420_1834191_+|6-phosphogluconolactonase
MTNERRVLVHPDKQSLGASVAARFITKIIDVLDEQERADIAISGGSVSTLVLAAIGQSPARESVDWSKVHVWWVDERWVAEGDADRNVTGTQTDFFEHVDIPQANIHPMAPSDAGLSIDEAAAQYERELQEAAPVGAVAPRFDITLLGVGPDGHTASLFPEFPQLAVTDRAVLTVDDSPKPPAQRLTLSFPVINASQRVWVILSGAEKASVLGLALAGAAVDEVPVGGVQGRKRTVFFVDQDAAREVPENLIASTY
>NZ_CP009755.1|WP_066654425.1|1834485_1834845_-|RNA-polymerase-binding-protein-RbpA
MATGGSAIRGSRVGAGPMGEQDRGVQAERVAVSYWDALGNEVVRYFSATLPDDEIPETVDSPSTGLPAGRDKENPPVVAKTEPYKTHLAYVKERRTEEEAAQLLEDALQQLRQRRGTAK
>NZ_CP009755.1|WP_058727797.1|1834848_1835100_-|preprotein-translocase-subunit-SecG
MAILSVVLQVLLAITSLLLTLLILLHKGRGGGLSDMFGGGVTSNLGASGVAERNLNRITVILGLVWIVSIIVLGLINKFTAGS
>NZ_CP009755.1|WP_066654426.1|1835220_1836000_-|triose-phosphate-isomerase
MNRRPFIAGNWKMNLDHLQAIATVQKLAWTLKDARHDHDDVEVAVFPPFTDLRSVQTLISADKLEIRFGAQDLSQYDSGAHTGDVSGAFLAALDAQYVIVGHSERRTLHGETDEVVAAKTAAAVKHGLVPVVCVGETGEEREQRGAGVVPVEQLKVVLEAVKPSEIVVAYEPVWAIGSGQAATAEQAQEDCAALRRGIAEAWGDDLAASTRVLYGGSVKSGNIAGFLREPDIDGALVGGASLDVQEFAAIARFRQHVGL
>NZ_CP009755.1|WP_066654427.1|1836043_1837261_-|phosphoglycerate-kinase
MSLRTLEDLGDLAGKRVVVRCDLNVPLKDGTITDDGRVRASLGTLNTLVNAGARVIVISHLGRPDGTPAQEYSLAPVAQRLSELLGKEVTFVGETVGDEATAAAEALGDGDVLLLENLRFNPEETSKDASARTAFAERIAALGDAFVSDGFGVVHRKQASVYELAAALPSAAGSLIESELTVLERLTKDPQRPYTVVLGGSKVSDKLGVIEHLLPQVDTLCIGGGMLFTFLAAQGHGVAKSLLEQDQLDTVRAYLAKADELGVTIDLPTDVVVASGFAADADHETVAADAIESSSFGTDGIGLDIGPETAARFASAVSGSKTVFWNGPMGVFEFPAFAAGTKTVAQALTEVDGLGVVGGGDSAAAVRSLGFSDDRFGHISTGGGASLEFLEGKSLPGLEALGWSR

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Crispr_ID: NZ_CP009755_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009755_7

1998161-1998260

Orphan

Consensus_repeat	Method
CGCTGTCGTACGACGACCACGGTGTCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009755_7

>merge|NZ_CP009755|7|1998161-1998260|CRISPRCasFinder
CGCTGTCGTACGACGACCACGGTGTCGCTCGGCCCGACAGCCGCGACCGGGCTCCGGTCAGGACGACAGATGCGCTGTCGTACGACGACCACGATGTCGC

>NZ_CP009755|7|7|1998161-1998260|CRISPRCasFinder
CGCTGTCGTACGACGACCACGGTGTCGC	TCGGCCCGACAGCCGCGACCGGGCTCCGGTCAGGACGACAGATG
CGCTGTCGTACGACGACCACGATGTCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009755.1\|WP_066654668.1\|1992893_1994414_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173859
NZ_CP009755.1\|WP_066654676.1\|1999811_2000726_-\|NmrA-family-NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|187569
NZ_CP009755.1\|WP_066654662.1\|1989502_1989859_+\|Fe-S-oxidoreductase	unknown	unknown	unknown
NZ_CP009755.1\|WP_066654660.1\|1988096_1989500_+\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224169
NZ_CP009755.1\|WP_066658332.1\|1990062_1990836_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP009755.1\|WP_066654680.1\|2001805_2003197_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP009755.1\|WP_081984906.1\|1995479_1996460_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP009755.1\|WP_081984908.1\|2006095_2007037_-\|3-hydroxyacyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|224170
NZ_CP009755.1\|WP_066654678.1\|2000847_2001819_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP009755.1\|WP_066654673.1\|1996456_1997269_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP009755.1\|WP_066654675.1\|1998360_1999800_-\|amidase	unknown	unknown	gnl\|CDD\|223232
NZ_CP009755.1\|WP_066654687.1\|2005398_2005995_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|376808
NZ_CP009755.1\|WP_081985301.1\|2003858_2004668_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|223156
NZ_CP009755.1\|WP_066658334.1\|1997310_1998048_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213224
NZ_CP009755.1\|WP_066654666.1\|1991888_1992833_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|274729
NZ_CP009755.1\|WP_066654664.1\|1990898_1991828_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NZ_CP009755.1\|WP_066654670.1\|1994529_1995483_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP009755.1\|WP_066654686.1\|2004700_2005402_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NZ_CP009755.1\|WP_066654682.1\|2003193_2003862_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP009755.1\|WP_066654692.1\|2007035_2007788_+\|acetoacetate-decarboxylase	unknown	unknown	gnl\|CDD\|179402

Protein	Function_ID	Function_description	E-value
NZ_CP009755.1\|WP_066654668.1\|1992893_1994414_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173859	cd08494, PBP2_NikA_DppA_OppA_like_6, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP009755.1\|WP_066654670.1\|1994529_1995483_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.51601e-93
NZ_CP009755.1\|WP_066654660.1\|1988096_1989500_+\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224169	COG1249, Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion].	4.01445e-106
NZ_CP009755.1\|WP_066658332.1\|1990062_1990836_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.5331e-125
NZ_CP009755.1\|WP_066654680.1\|2001805_2003197_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	5.27104e-25
NZ_CP009755.1\|WP_081984906.1\|1995479_1996460_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.32203e-69
NZ_CP009755.1\|WP_081984908.1\|2006095_2007037_-\|3-hydroxyacyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|224170	COG1250, FadB, 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism].	7.63282e-66
NZ_CP009755.1\|WP_066654678.1\|2000847_2001819_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	9.18972e-08
NZ_CP009755.1\|WP_066654673.1\|1996456_1997269_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.74325e-108
NZ_CP009755.1\|WP_066654675.1\|1998360_1999800_-\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	8.98466e-114
NZ_CP009755.1\|WP_066654687.1\|2005398_2005995_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|376808	pfam02525, Flavodoxin_2, Flavodoxin-like fold. This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.	8.33162e-40
NZ_CP009755.1\|WP_081985301.1\|2003858_2004668_-\|ornithine-carbamoyltransferase	gnl\|CDD\|223156	COG0078, ArgF, Ornithine carbamoyltransferase [Amino acid transport and metabolism].	2.80776e-72
NZ_CP009755.1\|WP_066658334.1\|1997310_1998048_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213224	cd03257, ABC_NikE_OppD_transporters, ATP-binding cassette domain of nickel/oligopeptides specific transporters. The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.	3.16735e-92
NZ_CP009755.1\|WP_066654666.1\|1991888_1992833_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|274729	TIGR03695, menH_SHCHC, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	3.52946e-19
NZ_CP009755.1\|WP_066654664.1\|1990898_1991828_-\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.80022e-78
NZ_CP009755.1\|WP_066654676.1\|1999811_2000726_-\|NmrA-family-NAD(P)-binding-protein	gnl\|CDD\|187569	cd05259, PCBER_SDR_a, phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs. PCBER and pinoresinol-lariciresinol reductases are NADPH-dependent aromatic alcohol reductases, and are atypical members of the SDR family. Other proteins in this subgroup are identified as eugenol synthase. These proteins contain an N-terminus characteristic of NAD(P)-binding proteins and a small C-terminal domain presumed to be involved in substrate binding, but they do not have the conserved active site Tyr residue typically found in SDRs. Numerous other members have unknown functions. The glycine rich NADP-binding motif in this subgroup is of 2 forms: GXGXXG and G[GA]XGXXG; it tends to be atypical compared with the forms generally seen in classical or extended SDRs. The usual SDR active site tetrad is not present, but a critical active site Lys at the usual SDR position has been identified in various members, though other charged and polar residues are found at this position in this subgroup. Atypical SDR-related proteins retain the Rossmann fold of the SDRs, but have limited sequence identity and generally lack the catalytic properties of the archetypical members. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.40984e-47
NZ_CP009755.1\|WP_066654686.1\|2004700_2005402_-\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	2.08569e-36
NZ_CP009755.1\|WP_066654682.1\|2003193_2003862_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.75712e-67
NZ_CP009755.1\|WP_066654692.1\|2007035_2007788_+\|acetoacetate-decarboxylase	gnl\|CDD\|179402	PRK02265, PRK02265, acetoacetate decarboxylase; Provisional.	4.16217e-126

>NZ_CP009755.1|WP_066658334.1|1997310_1998048_+|ABC-transporter-ATP-binding-protein
MPRRGPFEPGPVRTAVDGVDLTVASGARLGIVGESGSGKSTLVRLLAGLEAPTAGSVTAGGRPVVASASAAAMRWFRRETGVVFQDPYASLDPRMRVGAIVAEPLRALQLPGDHRALVASVLERVDLPADAADRYPHEFSGGQRQRIAIARAVVHSPRILLGDEPMSALDVVVRARVIDLFRSLADDLGLTLVLVSHDIGVVQRLCDTVAVLSEGRIVEQGPVSLLDDPRHPVTRALVAAAPTLP
>NZ_CP009755.1|WP_066654673.1|1996456_1997269_+|ABC-transporter-ATP-binding-protein
MSDHPTGRDGLEVTGLTVRIAGRTVLDDVTFTVPPGRRVGVIGASGSGKSMTSLALMGLQPTGAEVTGSIRLDGTELVGMRDRDLARHRGSGIGMVFQEPATALDPLRRVGAQVAEPLRLHRGLDRRAAATAAVALADAVGLPDPAALLRQYPHQLSGGQRQRICIAMAMAGSPAYLVADEPTTALDVTTEARILELFERLSTERGTGMLFVTHDLAVLARIADTAVVLDHGRVVEQASVRSLLDAPQHPATAALVDAARATARRTGGPA
>NZ_CP009755.1|WP_081984906.1|1995479_1996460_+|ABC-transporter-permease
MIRRLLARPTGCFAVVVLTLLVVLAAVSLVWTPQDPFRADPFQQWAAPSPAHWFGTDAAGRDIASYLLAGARTTVLVAIGSGVVASLVGIVLTAIGSLTTRWVREGTAVLLDILVAFPTLLTAMLLTAVFGGSLGVVVVSVGLSFGVTIARVARGEIRRIARSDYVVAARASGVGPLGVLTRHLVPNAAPLFTVQLSLAMATAVLAEAGLSYLGYGAGSDTASWGNLLADLQTYIGVHPWSATWPGAAIALVVAALSLLGDAVRDATDPRLTTGDRAVTGSPTATGTPAGDDPAPGEPTDDDPATGAPGADRRAPGGTTTTPGVTA
>NZ_CP009755.1|WP_066654670.1|1994529_1995483_+|ABC-transporter-permease
MTRFLVGRLLLLVVGLLVASIIVFATLRVLPGDVAQIVAGTQSTPAQVEQLRQQLGLDRPVVVQYLDWIGGVLRGDLGRSLVTNGAVGPEIAQKLAVTLPLAGMSLVAALVLGVPLGVLAAVLRRRAGGAVIGFVAQAVAAVPVVWAGMLLIALFAVTLHWLPTQGFPLDGWDEPGRAFSSLVLPALTIGAVEGAVILRFTRSATLTVLDADHVRTAAAIGLTRTRALLRHGLPSVALTVLAVLGVQIAGLLVGAVVVEQLFSLPGVGRMLVTDVGRRDVTKVQSELLVLTSLVLVVGFAVDVVHRALDPRQREVGE
>NZ_CP009755.1|WP_066654668.1|1992893_1994414_+|ABC-transporter-substrate-binding-protein
MSPLLPRRGGRAARVALAATAVAVASALTLTACSGSDSSSGGDDATVRVGLVLEPTSLDIRTQSGAALDQVLIDNVYQGLVGRTADGEIRDVLASKHEVSSDGKTYTFTLRDGTTFQDGKPVTAADVVWSLQQAKDNSSYVDSAKLAGVSSISSPSDGVVELQLEAPDSDLLFNLTGRAGLVLEQAATNDLSDSANGTGPYEVSAWKQGDSLTFSRNDDYWGTEPKVAKIVFRYITDPSTAVNAMANGDLDVLNPVDGTLQGQLQGNPDIELHRGKTTDKYTLAFNDAQAPFTDERVRRAIRQAIDPKALIKAIGGTGVEQGGPIPELDPGYEDLTDIDAYDPDNAKKLLAEAGKTDLDLTLTYANVYPATIGDVLKSQLADVGITLKVERVDFATWLDQVFTKKDFQLSVVDHVEARDFGNWANPDYYFGYDNREVQRLYAESIAATSQTEKEQALRKAARIVSEDAAGEWLYTATEITAVRKGVTGFPVDGGNSRLDLAGLAVR
>NZ_CP009755.1|WP_066654666.1|1991888_1992833_+|alpha/beta-fold-hydrolase
MHEPDDEFSDLAALAAASGVTEPLRASRQVVRTDDGRETAAIRWDTADGREARITYLHGLGIDAHSFDQTAIAVGQPAVALDLPGHGRSSWRDDADYGASATAPQVLAALDALGVPPGVVVGHSLGAILAARLAATSPERVTGLVLVDMSPDFAQRAVDRIARALEDETPFASLDEVVDRAVEARVGDDRAVLLREARHTTRLGEDGRLVRRHHFPHLPSGRTASVGRFADAWPDLEALAVPVLLVRGDRGYVSPKLHAGFTERLPDAEVVTVTARHAVQNQAPLELASAIRAWGARHRLLHEVQQPSSGPERR
>NZ_CP009755.1|WP_066654664.1|1990898_1991828_-|siderophore-interacting-protein
MPYSYLVAARYRVFSVRVAAVSALTPSFVRVTLTGDALADFSAVGLDQRIKVVLPIPGHGFTDLPDGDDWYGAWRALPDAERNPLRTYTVRSFRPDARELDIDFVAHGDTGPASRWVSACRVGDELRIVGPAVPSSPAELPSGAAEFAPGSATRILLAGDETAAPAICAILEALDVATVGHVFIEVPTDADRLPVTAPAGVEVRWIARNGASHGVRMTDQVHAWAAEVTTGAASVAEPVRGAVDLADVDVDEQVLWDVPAALDERPVYAWIAGEAGCVKELRRHLVRGVGLDRRQVAFMGYWRHGKAEH
>NZ_CP009755.1|WP_066658332.1|1990062_1990836_-|ABC-transporter-ATP-binding-protein
MGARGLTLAYDDRTVVSSLDVDVPDGELTVIVGPNACGKSTLLKAFARTLRPSAGTVFLDGTPIDSLRPKAVARRVGMLPQTPVAPEGITVRDLVSRGRFPHQDLLHPSSGSDRTAVQAALEQTDTVSLADRSVGELSGGQRQRVWIAMVLAQETDIVLLDEPTTFLDIAHQYDVLELASALHAAGRTVVAVLHDLNQAARYATHLVAMRDGAIVAQGTPAAVLTSELVEDVFGLPCVVVPDPETGTPLVVPRRRVA
>NZ_CP009755.1|WP_066654662.1|1989502_1989859_+|Fe-S-oxidoreductase
MRNPLLDSPVSRAGWVFATAVGLAVGVPFSTGRIRVEDGLIVCTGLPRWAFRRGGTCVGSVYLTRDNDGPRVLRHERVHVTQWRRYGMLMPLLYALAGRDAARNRFEVEAGLEDGGYR
>NZ_CP009755.1|WP_066654660.1|1988096_1989500_+|NAD(P)/FAD-dependent-oxidoreductase
MTDYDLIVIGAGAVGENVADYAHKRGLSVAVVEAELVGGECSYWACMPSKALLRSGHAVAAAKRVDGAAQAVTGHVDAAKVLARRNSFTSDYQDDSQVAWLESADIALIRGHARITGEKTIEVGGETHTARAAVAVVTGSLHQLPDVSGLADAQPWGTREGTSAQQVPESLLVIGGGVAGSELATAWASLGSKVTLVARHGLLGGMEPFAGELVADAMRELGIDVRTGVSPTRVDRDEHGLVTTTLDDGTTVVTSEVLAATGRKAHTADLGLDSVGLTPGDWLQVDDTMLVQGTDWLYAVGDVNHRALLTHQGKYQARAAGEAIAARAQGRPVHAEPWGAHVATADHAAVPQVTFTDPEVASIGLTETAAREQGIDVRAVEYDLGAIAGSALQADGYTGRAKMVVDESRGVVVGVTFVGQDVAEMLHAATVAVVGEVPVDRLWHAVPAYPTMNEVWLRLLETYGRPE
>NZ_CP009755.1|WP_066654675.1|1998360_1999800_-|amidase
MFELHHLSAQELWDWIRRGDATALEVTEHYLARIERLDPSLGAFVAVTADSAREHAARLGTLLPTSRPLWGLPTADKDLYDRAGVPTRHGSAALPVTPATADHPLVAALAAAGTVSLGKTTSPEFGMSSSSETRIGTTRNPYDTTRAPGGSSSGTAVAVAAGLVPAAVGTDGGGSVRIPAAATGLVGLKPSRGRVPSMPGRSGLGGLSVAGPITRNVADAGMLLDALVAPTGLPEPSPYALVTPDVGDGPFTAAAVRGEGRFVVGVLDGSPWDDTVDVVVDPAARAAVDTAVRVLGEVGHGVEDVAMPRLPYADAFRVAWESGAAGLPRVPGIDLSALTPLVSWLVERGRALTATQVLDAMTTLDAFSAGLIRTFAPYDAVLTPTLALTPRPLGWYGDDPEEDFRRQCAYSPWTSMANVSGLPAITLPVGVTDDDHPDGAGLPMGVQLIGRPGGERVLLAIGAQLERRLRWQRRHPATW
>NZ_CP009755.1|WP_066654676.1|1999811_2000726_-|NmrA-family-NAD(P)-binding-protein
MTSTTVLVAGATGDLGSRIVDALLAADPDVRIRALSRSATGPAADRLTARSDRVSVVSAAYDDHDGLVTALAGVDVVVSAVSGTRSVVVDAQTALLAAAVDAGVPRFVPSDYSADYRAITPGTNRNFELRREFAATLDAAPIRATSVLNGAFTDMLSGQAPMILFDRRTVLYWSSPDQVLDFTTKDDTAWVTARVALDPDAPRVVEVAGDRVTARRVADTLSRLTGTRFRTQWAGTSGTLSAMARVGRRLSRADDAEPFPAWQGMQYFVSMFSGEAELHHVANDRYGPHDWTTVRDVLAVHLQA
>NZ_CP009755.1|WP_066654678.1|2000847_2001819_+|CPBP-family-intramembrane-metalloprotease
MTNTTEVRPGAGTAAPRATGVRGVVSRHPLASFATLALGLSWLAWVPYILSPHGLGVWDLHFPEFLGTAQFTGILPGALLGPLGGAFVVTALADGRPGLRRWVGRLWRWRVSWYWYALALVGVPALIVLTGLPFSGGNVQAPTALALLALVPGLVVQLFTTGLSEEPGWRDFALPRLQDRFGPLGAAAVLGPLWALWHMPLYLSDWGGWPDAHWSEPVVFALFTITFNVVMTWVFNRTGESLPIALLLHVGVNNTISTLWADMYPGMTAGTMMHGLTIVSTVAAAVLLVATRGRLGYDRRPGGTDHLSASASARLVGSNDGTR
>NZ_CP009755.1|WP_066654680.1|2001805_2003197_+|sensor-histidine-kinase
MAPAEASAARVAADPRTAREVDGGRRLRRADVLVAVATAVVSLALLLGLPYLDAVDPDTIGHPLSAPEVGSADWTAVALGLLVQSAVLLAARRLPRAVLLAVAAVPVLVVAVTSGGDLFGLTALPVVVAVVLAALRVPLTRLWPSVVGAAALVSAGTAGNWIELNGALSGRSLADALGDALPQGVTQAIGAVGLPVVVALVVRSRREVRAARDAEVAARTAEASAAVREQDARVDAAVSRERAAMARELHDIAAHHLSGIALMSAVIDRQIDTDPTAAHEGVRQVREQSTAVLEDLRRLVGLLRDDAPAERAVETVAGIVDLVERARYRSDVRLEVLRGAHEVAEGVGPLAQLAAYRTAQEALANAALHAPGAVVTVTLDDRAVDHLELTVENAAPAVSAPSADAPAGPGEPTPEGPGAGGNGLRGMRERADLVGARLQTGTTPDGGWVVTLRLGRETPEVTR
>NZ_CP009755.1|WP_066654682.1|2003193_2003862_+|response-regulator-transcription-factor
MIRVLVADDQPLVRAGVSALLAAEPDVEVVGVAADGGEALTLARSTRPDVAVLDIRMPVRNGIEVARELCAPDADPAVPVLVLTTFDLDDLVFGALEAGASGFLLKDAEPDVIVGAVRQVAAGNGTIDQSLTRRVLREFVSRRSLQPVTGDRASELLTARERDVLLLLAQGMSNEEIAEALVVEVSTVKSHLARMLPKLGVRSRLQAVVWAYQNRVVAVPEG
>NZ_CP009755.1|WP_081985301.1|2003858_2004668_-|ornithine-carbamoyltransferase
MRLDDWTTDDTDAVFALARAYEQGTGPVLDGAAAVFFPPTSLRTRASFERGAALAGLQPIVFPPESLDKDEAHEDVARYLADFVDVLVVRHRDLSVLEALAAADAVPVVNAMTSVNHPCEVLADLWALTRGRAVGSLRVRFVGADGNIARAWAEASRLFGFDLLQCCPEGLGAPDVVWTEDLAGAMADADVVVTDGPGRHAAALEPYRVTADVLALAPDGVRFAPCPPFVRGREVSADAIASPAFVGHGAKRALLPVQQAVLAHCLAGA
>NZ_CP009755.1|WP_066654686.1|2004700_2005402_-|HAD-family-hydrolase
MTLDVRAVVFDLDGTLFDHAGAAARAVDDLLGALGVAATDRLRAAWAEAEERHFERWRRGEVDFAEQRRARLVEVLPLAGLRPPHDPHELDLLFGRYLAAYRGAWRPFPGSAPLLRAVRDADRPVGVLTNGTEEQQRDKLAATGLSDLVDVVCTSERIGVAKPDRRAFEQVADELGVPAAACLFVGDDPQRDVAGARAAGMRAVLVDPARDGGAAVRSSVLSALHGASGTGRR
>NZ_CP009755.1|WP_066654687.1|2005398_2005995_-|NAD(P)H-dependent-oxidoreductase
MSTLIVTAHPDPDSLTLAVAHRLEAALDAAGAGPVTVADLAAEGFDPRFTAADRHTYRTGTDPAPDVAAEQARLDGIDHLVLVFPVWWWSVPALLKGWLDRVFVNGWAFGVGEDGRIDRRLGRLTVHLLPIAGDDAGVYERHGYEQALRTQLEHGLVDFCGAARGATAFVHESEHEDTTVRERAVAAAVGRVVDAVRG
>NZ_CP009755.1|WP_081984908.1|2006095_2007037_-|3-hydroxyacyl-CoA-dehydrogenase-family-protein
MRISFGTWIRSVSNTNCTELDREQEPVPYQPPRDTADRPVTVIGGGTLGRRIALMFASGGAEVRIHDLSEEVRAAAVAYVEETLPGIVAARDGATAGTVRGEADLEAAVVDAWLVVEAVPERLDLKTPLFGRLDALVAADTILATNSSSYASRLVIDEVAHPERVLNVHFYMPPQQNAVDLMSDGQTDPAVIDLLLEALPRYGVHPFLARRESTGFIFNRIWAAIKREALAVVADGVSTPEDVDAMWQVNSGAPAGPFRMMDQVGLDVVLDIEEHYAAEDPRLPEGPRRLLREHVDAGRLGVKTGQGFYRYDD
>NZ_CP009755.1|WP_066654692.1|2007035_2007788_+|acetoacetate-decarboxylase
MRADDVLQHLTTPLAAPVYPLRPTRFTGREYFNVVYRTDPDALRAVVPEPLEVTEPLVRFEVMKMGEVDGYGPYVESGQAIQVEHEGERGEYLHAMYLDNAAATLAGRELSAYPKVLGTPALRVDQGALVGTLDRGTERVATATMAYEWEPLAHDAALAEITVPTFMVKLVPDLRTQRHLVADLVRTEITDVKVEQAWTGPARLQLFAHALAPMADLPVLEVVRASHILTDLTLAPVRTVHDYLADRHSA

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Crispr_ID: NZ_CP009755_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009755_8

2887833-2887921

Orphan

Consensus_repeat	Method
CGGGCGGGAACACCCCGACCGCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009755_8

>merge|NZ_CP009755|8|2887833-2887921|CRISPRCasFinder
CGGGCGGGAACACCCCGACCGCTCCCACCGGCACCCCCTCAGGGAGCCCGACCGGCGGAGCGGCACCGGGCGGGAACACCCCGACCGGT

>NZ_CP009755|8|8|2887833-2887921|CRISPRCasFinder
CGGGCGGGAACACCCCGACCGCT	CCCACCGGCACCCCCTCAGGGAGCCCGACCGGCGGAGCGGCAC
CGGGCGGGAACACCCCGACCGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009755.1\|WP_081985067.1\|2889344_2890070_+\|GrpB-family-protein	unknown	unknown	gnl\|CDD\|377252
NZ_CP009755.1\|WP_066656282.1\|2890604_2890922_+\|ArsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|316153
NZ_CP009755.1\|WP_066656281.1\|2890176_2890608_+\|chemotaxis-protein-CheY	unknown	unknown	unknown
NZ_CP009755.1\|WP_081985071.1\|2893719_2894121_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|379263
NZ_CP009755.1\|WP_144411370.1\|2880550_2880841_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_144411373.1\|2894580_2896602_-\|RNA-directed-DNA-polymerase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|238824
NZ_CP009755.1\|WP_066656261.1\|2882342_2882903_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP009755.1\|WP_081985064.1\|2881162_2881825_+\|RES-domain-containing-protein	unknown	unknown	gnl\|CDD\|378053
NZ_CP009755.1\|WP_144411371.1\|2888362_2889328_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224513
NZ_CP009755.1\|WP_066656289.1\|2893195_2893825_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP009755.1\|WP_066656268.1\|2885269_2885848_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223508
NZ_CP009755.1\|WP_158407770.1\|2891014_2892013_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004
NZ_CP009755.1\|WP_066656266.1\|2883846_2885118_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NZ_CP009755.1\|WP_158407771.1\|2892208_2892823_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066656263.1\|2883065_2883473_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_081985066.1\|2881902_2882346_+\|SdpI-family-protein	unknown	unknown	gnl\|CDD\|379303
NZ_CP009755.1\|WP_066656258.1\|2880882_2881308_+\|PRC-barrel-domain-containing-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_158407772.1\|2896594_2897845_-\|hypothetical-protein	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|238824
NZ_CP009755.1\|WP_144411369.1\|2879556_2880042_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066656234.1\|2878593_2878920_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP009755.1\|WP_081985067.1\|2889344_2890070_+\|GrpB-family-protein	gnl\|CDD\|377252	pfam04229, GrpB, GrpB protein. This family has been suggested to belong to the nucleotidyltransferase superfamily. It occurs at the C-terminus of dephospho-CoA kinase (CoaE) in a number of cases, where it plays a role in the proper folding of the enzyme.	1.87189e-45
NZ_CP009755.1\|WP_066656282.1\|2890604_2890922_+\|ArsR-family-transcriptional-regulator	gnl\|CDD\|316153	pfam13601, HTH_34, Winged helix DNA-binding domain.	2.89289e-26
NZ_CP009755.1\|WP_066656261.1\|2882342_2882903_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	3.33858e-17
NZ_CP009755.1\|WP_081985064.1\|2881162_2881825_+\|RES-domain-containing-protein	gnl\|CDD\|378053	pfam08808, RES, RES domain. This presumed domain contains 3 highly conserved polar groups that could form an active site. These are an arginine, glutamate and serine, hence the RES domain. The domain is found widely distributed in bacteria. The domain is about 150 residues in length.	1.03676e-08
NZ_CP009755.1\|WP_144411371.1\|2888362_2889328_+\|transcriptional-regulator	gnl\|CDD\|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	5.00408e-43
NZ_CP009755.1\|WP_066656289.1\|2893195_2893825_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.3061e-07
NZ_CP009755.1\|WP_066656268.1\|2885269_2885848_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223508	COG0431, COG0431, Predicted flavoprotein [General function prediction only].	3.1358e-20
NZ_CP009755.1\|WP_158407770.1\|2891014_2892013_+\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	2.44304e-20
NZ_CP009755.1\|WP_081985066.1\|2881902_2882346_+\|SdpI-family-protein	gnl\|CDD\|379303	pfam13630, SdpI, SdpI/YfhL protein family. This family of proteins includes the SdpI and YfhL proteins from B. subtilis. The SdpI protein is a multipass integral membrane protein that protects toxin-producing cells from being killed. Killing is mediated by the exported toxic protein SdpC an extracellular protein that induces the synthesis of an immunity protein.	1.74321e-07
NZ_CP009755.1\|WP_144411373.1\|2894580_2896602_-\|RNA-directed-DNA-polymerase	gnl\|CDD\|238824	cd01646, RT_Bac_retron_I, RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA branches out from a small ssRNA molecule via a 2'-5'phosphodiester linkage. Bacterial retron RTs produce cDNA corresponding to only a small portion of the retron genome.	1.31095e-34
NZ_CP009755.1\|WP_066656266.1\|2883846_2885118_+\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.31604e-35
NZ_CP009755.1\|WP_081985071.1\|2893719_2894121_+\|SDR-family-oxidoreductase	gnl\|CDD\|379263	pfam13561, adh_short_C2, Enoyl-(Acyl carrier protein) reductase.	1.01649e-22
NZ_CP009755.1\|WP_158407772.1\|2896594_2897845_-\|hypothetical-protein	gnl\|CDD\|238824	cd01646, RT_Bac_retron_I, RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA branches out from a small ssRNA molecule via a 2'-5'phosphodiester linkage. Bacterial retron RTs produce cDNA corresponding to only a small portion of the retron genome.	1.27439e-19

>NZ_CP009755.1|WP_066656268.1|2885269_2885848_+|NAD(P)H-dependent-oxidoreductase
MTPLRLPVISCSLDPVSTSRRLAERSASLLRANGHGSEVVDLATAPLPAFDNDQVFDSDAFGALHDVIRESDGVVLAFPIYNWAPSSAVKSLIEATGATGEGRRAAWFDKVVTFVCAAGLPHSYMATGALAQSLMLDFKCVVNPYTAYIAERDWEAGTLSVDRAARLEKTMTVHAELAGLLRDRTSLSDWEV
>NZ_CP009755.1|WP_066656266.1|2883846_2885118_+|MFS-transporter
MRFTPARLRAPLASLHEHRFVTFAVLTDTIGAGLTLPLTIVYFTITTDVSLAVIGVLSTVASLVALPIGLVGGVLTDRFGARASMVLNNLLSAAGFTLYLSAHDPVVIFAAIFLANASERLYWTSWTAYVHDLAAGRPFERWFAFLEATKAAALGAGAIVAAVTLAHGHQDGLRWLVLANVVTSVAAAVVFATQRTGHRAPQAAAPTGAGPADASGLLRAFVADRSMRLIALGQFLIGPAMLLPNVAFAVLFIERWGVSPAVAPVQFAIATGLCALFQTSVTRWVAGRRRGTLIALGAVLTAATTAPLIVLPPLHGPAAWSYVVVVAVVLAAADMISLPAANAVMAAAPHPRIRGRAIGVFQTASSIGMALFPLTLGLLDSRMPWLLWLIATGVFLGAAWAWHGAVRDLPQRVQGTEPTDIDG
>NZ_CP009755.1|WP_066656263.1|2883065_2883473_+|hypothetical-protein
MDHKDTRSGLPYDSWPESEVDDQRTIAQVNSSRKAFRITARTGFIIAPAMFLLPLVYPLLGLGWHFLPIICMTAAWAVLVSACSFAAMTTTEPAGHPWVHQVWAVPAAVLAMFPGGIAAFALYGSVVATVYQRTK
>NZ_CP009755.1|WP_066656261.1|2882342_2882903_+|histidine-phosphatase-family-protein
MMLCTWVSHPEVTVDPTVRIQDWGLSPVGRARAAHIATLFPQPLRIVSSSERKALDTAGIIAGQWGSEFEVDEDLGEMDRSATGYLDPREFEPTVDAFFAEPHRSARGWERAIDAQSRVERAVRRIAAQTPERGIAFIAHGGVGALLLASLRREPISRALDQPAMGSSFAFDPQDWTALSSWEHVG
>NZ_CP009755.1|WP_081985066.1|2881902_2882346_+|SdpI-family-protein
MDGAVVFPMALEIGAAALVTWLTWRAANGSLPRNSLAGVRTSVTMSSEAAWRIGHRAALRPTIVSGLLVTAWCAISIGVPALHTPAAVLVAAGLLVGGALLSIPAAHRAVRRALPEAGGDGSHPDGSPATPSPVSSERDTDDADTVG
>NZ_CP009755.1|WP_081985064.1|2881162_2881825_+|RES-domain-containing-protein
MPSASTSGCPRQARRPATWATRTRTSTRPVPVRRALTTPRARERRRRREPHQDALVSDDRDIFAPEVRGTFFRAVDPRFRASAIAGSRSAGRYSRADEPTLYLSSSVEGVEAALVAHPDTRATEPMIVEVDVVASRIVDLRDRAARSEAVVDLEDATAPWQQVVADGGVPASWQVRDRLVALGADGLIDPSRKRPGLWHLVLFRWNTDGAPQVRVRTEAG
>NZ_CP009755.1|WP_066656258.1|2880882_2881308_+|PRC-barrel-domain-containing-protein
MITKAKIHEIENAPVKDRDGASVGKVAQVFPSAEDGSAAFISVATGLLGGHTVLVPVEDATFDGNDLHVGYLKSAIKDAPSPGAGNTVTDTQADAVRKHFGLSPAGKATGDMGDPHENLDQAGTGPAGADDTEGAGATPPA
>NZ_CP009755.1|WP_144411370.1|2880550_2880841_+|hypothetical-protein
MRDNGARGAAYLLTEMREQRAGDPADDVATVERLWKDKGLSTERHESGGTDPTQGVRGTGGPATSIDFLADERGYSLDAVSVCTAGNAEELQRNGE
>NZ_CP009755.1|WP_144411369.1|2879556_2880042_+|hypothetical-protein
MNRPSARSEPRATDAKAAWDDLNERIESTQLMVPGEWEASDSGASACGTSGAQWGITRLGPGASADDRTRIIARIETAWKDNGWEPTRSTFGGDAPGLQLRYPAGGVFDDGFFVEIGITEYGSSIQAQTPCAQGDVNVLNDEQYAYEHQDTTRLPSAGPSS
>NZ_CP009755.1|WP_066656234.1|2878593_2878920_-|hypothetical-protein
MNRKTIVALASGFVALGAIVALAAPAEADSYSETSAMAQAVEAGSSQTAAAEASPRGVGGVAKALWAGFKAAHAPRAAGNVARMASVLGYAADTPQGSSEAEKAYFDR
>NZ_CP009755.1|WP_144411371.1|2888362_2889328_+|transcriptional-regulator
MQDPSRQRTAAVVINPVKTDPTRLRTLVDAEASRNGWAPTRWFETAADDDGRAAAREAAESKPDVVLVAGGDGTLRVVAEELRGTGVPVALLPSGTGNLFARNLGLTRNDVDSAVHDAFTGADRPIDVGLAELTDVDGSTTTHAFLVMAGVGLDASMAADTNAWVKKRFGWVAYSDPIARSIVGNRQIPVRYDIDGAPTRTMHAHTIIVGNCGTLTAGVLLLPRAEPDDGILDAVAFRPNGWFGWTKIGSTLTLNRFFSRTGFGRLFARLLPRSRVLPTTRARRLRLAFDEPEQVQLDGDPFGRVVAVTLSTHPHGLTLRA
>NZ_CP009755.1|WP_081985067.1|2889344_2890070_+|GrpB-family-protein
MVTRRPCERRAHTTTGQCSRPSPDIPRPADASRVHDVAVATHPLWRPFTADGNAARQSQRVAFRQVDPGSLQDHDPRWADAFARVRDLVAGALGADHTIAHVGSTAVPGMIAKPVIDADLLVPDLGDERTWLPELEAVGFRLVFRDVIAGDPHRQLTLGDPNTNLHVWQPGAAEPQRHRLFVEWLRSHPEDRQVYADAKAAAVNAGNGLRYNDAKAAVVHEIYERAFASDPHHAHDAQPRP
>NZ_CP009755.1|WP_066656281.1|2890176_2890608_+|chemotaxis-protein-CheY
MDNQNSISPAEARTLLDTADRLSRRAHESTRWPYVTFILALGMVTSFGTLGMGLTTGSAFGLTYVGTLAAFFALIVFFAVSIRGRAAFARSRRWTIYIASWFVTYGAAIAVVAWAHGSVLWSGITSGAILAVTMACASYEARR
>NZ_CP009755.1|WP_066656282.1|2890604_2890922_+|ArsR-family-transcriptional-regulator
MTSTNQAPVHPRHRLDGHLLNPVRFSIMAALDRATTLGFREVRDAVEVTDSALSKQVALLETAGYVAVGKAFTGKTPRTSLTVTREGRTAWRAHLAALQEIADPS
>NZ_CP009755.1|WP_158407770.1|2891014_2892013_+|HD-domain-containing-protein
MHREAVDTLGNDGVYFDPLWRIEVRLTATEQRLLRTWPVRRLAFIAHAGAASITTVQTYSRLEHSLGVLALVAHFAPEHQPARTAALLHDVGHLPFSHTLEGLAGLDHHDLTRQRITALFATDAALAGDAETIIALDDGSIPSPLTASHGGLKLDHLDSFLRSGQAHGRTRSAPHELLRRLHLSDGAVDADPVDAVELADLAISEALAQRSAANLVPVAVVRGLVSRLFDTGALEPTELAGMTDDELWSVLLSSAATRADAASLRRHPQRWQLRHHSDDSCGEPFSHVVRRSYLDLPRSGGRTTSDPRVAALQEDLPMWVSAKRSDDRTHVA
>NZ_CP009755.1|WP_158407771.1|2892208_2892823_-|hypothetical-protein
MSKGDGTAVVEYTAPNETTLGSALRIPGLDHDAVNRAAGRPRAVLAGDGAVHVEGEGEVVAKHPAGIATSIAVLTLLMTGCAVTAQPEPEDYTGTWVLEGADGDRATEFTVSADRTYTARNIPIDLACRTGNAATGPPGCANGEDSASFSGRWKVADGDSPGIRFYFDGQLVRQGYATNGALGFYSGSLDVPRPDYLFVRSSSA
>NZ_CP009755.1|WP_066656289.1|2893195_2893825_-|TetR/AcrR-family-transcriptional-regulator
MPRPRKFDEAEVVERARRTFAESGFDGTSLDDLLAATGLGRQSQYNTFGGKKELFMRAFLSDTADAVEVVQSVLRSAEHPIARIRTQLVSAAVEHGAAQGPPSLLLRAAVELSARDPEVAATVTEAFDTIRAGYTACIVDAQAAGEVEAAADAEALGTYFCAVIEGMGAIGRVGTSRAALLQVGIASLAALPITPLGAEHLGTADGPWD
>NZ_CP009755.1|WP_081985071.1|2893719_2894121_+|SDR-family-oxidoreductase
MPAGRRATCRRTRTPRTCAGRARPLRPRRTCAVGACTWAAELAPRGVWINTVVPGPTGTPGLAGPATGSPDAMLQQMASGLPFCRLLRPEEVAATVLFLVSDQSSGMTGSELLIDGGSSIACASFPGQYRRHD
>NZ_CP009755.1|WP_144411373.1|2894580_2896602_-|RNA-directed-DNA-polymerase
MSKSRRGIKHGPGRVVLSDTLPFELPVGFDNSAWYSFLNLAKFEWDADGYKFRADKDGLHELVLKIVFGGVAEVSVASAERLEVRFFKRPSPTVPFQFVINTRNGRGRLLSVPHPAIQLRIARFYDKYRALILHHSRRSNFSLRAPSRVARYTTVRDSLFAADRDRSTRETVEVRDRESRALHSYFVYREVASLHRFYESRSYREAEKHYSMLTRLDLSRCFDSIYTHSIAWALHEREVVKRSVASHKMTFAGEFDALMQLMNDNETNGILIGPEVSRIFAEMILQGADRSLERVLRSREVVHGRDYQVLRYVDDYFIFHNDPAVERVIVSELENELRPYKMNLNSAKEERLSAPYISPMSSAKRALNRAISRQLPLPATDSNIVTGEYVVRNLLHEFKTVVLQSGLSAADLANYSTAVVELRLEEVLRAAAHGADPELSALSSATSAHLLALVSGSMEFLFYVYGSTPLVSGAVKLARAVAMVRRFMSEWNFPYSSRLLVDELIGRECSRLLRRMKLEAGVESVYLLDVLAELPRDFDLSEAEFRHVTGGLSFEANTGELALLEVFGVLRYAGPRAHLQPFVLASERWLKTRAAELQKLQRPSSELVLLVLDAIASPWVDDAVKGHLLRLFVPKASNSKAVELAALQEGWFGRWRWDDLYAELRLKRVHEVY
>NZ_CP009755.1|WP_158407772.1|2896594_2897845_-|hypothetical-protein
MLTTWDDALRLAIEKRNHLRAQIRRAERLTNVSITSALELAHKESEDVATKELDRFLDEVRGQVQSRLEANDRWVLTEGITLNGKRTWHTDRKMNAASYFEERIAERALRSSFDISSPSRAHVSDALKTVLTDGSPKFVYRTDIRGCFESIPHAGLLEMLEANRELPRRVVKQVRNLLSDYSAIVGSAVGLPRGVGISSVLTEVYLSALDRQIEEQLLPAFWCRYVDDIVVVTSAERGRDASKVIKSAVKNLSLALNASKTISFASGTPRTFTFLGYQYSWPSGSLLVQMSSKRSKRMRLRLERAFDAYSSSTSPARGDLLIKRVRFLTRNVRLSNNKRNALTGIYFSNSQLDTPSRQLQALDRRLSALTKQRVSEPGIFQLIHQESFAGGFVSKRFLVLTPEEMTRVTAIWIDLE

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Crispr_ID: NZ_CP009755_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009755_9

3009769-3009968

Orphan

Consensus_repeat	Method
GCCGCTGTCGCACGACGACGGTGATGTCGCACGA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP009755_9

>merge|NZ_CP009755|9|3009769-3009968|CRISPRCasFinder
GGCGCTGTCGTACGACGCGGCCGCTGTCGCACGACGACGGTGATGTCGCACGAATCGACCTCGCTCGAGCCGGATCGGCCGAAACGACACCGCCGCTGTCGCACGACGACGGTGATGTCGCACGACCCCACCCCTACTCCCGATGCACGGGACGTCCCGCGCCGAAGCACCTGTCGATCGACCCGCGCGATGTCGGCCGA

>NZ_CP009755|9|9|3009769-3009968|CRISPRCasFinder
GGCGCTGTCGTACGACGCGGCCGCTGTCGCACGA	CGACGGTGATGTCGCACGAATCGACCTCGCTCGAGCCGGATCGGCCGAAACGACACC
GCCGCTGTCGCACGACGACGGTGATGTCGCACGA	CCCCACCCCTACTCCCGATGCACGGGACGTCCCGCGCCGAA
GCACCTGTCGATCGACCCGCGCGATGTCGGCCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009755.1\|WP_066656496.1\|3004596_3005097_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066656492.1\|3004151_3004427_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NZ_CP009755.1\|WP_066656515.1\|3013437_3014274_-\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NZ_CP009755.1\|WP_066656508.1\|3006813_3007641_-\|ammonia-dependent-NAD(+)-synthetase	unknown	unknown	gnl\|CDD\|234831
NZ_CP009755.1\|WP_066656529.1\|3019332_3019710_-\|cold-shock-domain-containing-protein	unknown	unknown	gnl\|CDD\|239905
NZ_CP009755.1\|WP_066656505.1\|3005129_3006578_-\|flotillin-family-protein	unknown	unknown	gnl\|CDD\|259798
NZ_CP009755.1\|WP_066656486.1\|3001912_3003628_-\|adenosylhomocysteinase	unknown	unknown	gnl\|CDD\|235488
NZ_CP009755.1\|WP_066656516.1\|3014490_3014985_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|224321
NZ_CP009755.1\|WP_066658729.1\|3000518_3001868_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238637
NZ_CP009755.1\|WP_066656523.1\|3016600_3017296_-\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NZ_CP009755.1\|WP_066656513.1\|3010154_3011594_-\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|235434
NZ_CP009755.1\|WP_081985333.1\|2999997_3000495_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|377622
NZ_CP009755.1\|WP_144411381.1\|3011740_3012064_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066656511.1\|3008537_3009674_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP009755.1\|WP_066656519.1\|3015362_3016310_-\|C40-family-peptidase	unknown	unknown	gnl\|CDD\|366353
NZ_CP009755.1\|WP_158407773.1\|3007717_3007885_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066656489.1\|3003762_3004026_+\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|239274
NZ_CP009755.1\|WP_066656526.1\|3017461_3018580_+\|phosphoserine-transaminase	unknown	unknown	gnl\|CDD\|130433
NZ_CP009755.1\|WP_081985101.1\|3018649_3019333_-\|DUF3027-domain-containing-protein	unknown	unknown	gnl\|CDD\|378605
NZ_CP009755.1\|WP_066658732.1\|3012323_3013427_-\|epoxide-hydrolase	unknown	unknown	gnl\|CDD\|377658

Protein	Function_ID	Function_description	E-value
NZ_CP009755.1\|WP_066656492.1\|3004151_3004427_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	2.73975e-09
NZ_CP009755.1\|WP_066656515.1\|3013437_3014274_-\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	7.0168e-14
NZ_CP009755.1\|WP_066656508.1\|3006813_3007641_-\|ammonia-dependent-NAD(+)-synthetase	gnl\|CDD\|234831	PRK00768, nadE, ammonia-dependent NAD(+) synthetase.	4.5524e-168
NZ_CP009755.1\|WP_066656529.1\|3019332_3019710_-\|cold-shock-domain-containing-protein	gnl\|CDD\|239905	cd04458, CSP_CDS, Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. CSP expression is up-regulated by an abrupt drop in growth temperature. CSP's are also expressed under normal condition at lower level. The function of cold-shock proteins is not fully understood. They preferentially bind poly-pyrimidine region of single-stranded RNA and DNA. CSP's are thought to bind mRNA and regulate ribosomal translation, mRNA degradation, and the rate of transcription termination. The human Y-box protein, which contains a CSD, regulates transcription and translation of genes that contain the Y-box sequence in their promoters. This specific ssDNA-binding properties of CSD are required for the binding of Y-box protein to the promoter's Y-box sequence, thereby regulating transcription.	1.4695e-20
NZ_CP009755.1\|WP_066656505.1\|3005129_3006578_-\|flotillin-family-protein	gnl\|CDD\|259798	cd03399, SPFH_flotillin, Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. The flotillin (reggie) like proteins are lipid raft-associated. Individual proteins of this SPFH family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. In addition, microdomains formed from flotillin proteins may be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and interact with a variety of proteins. They may play a role in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and in cancer invasion, and metastasis.	1.88211e-33
NZ_CP009755.1\|WP_066656486.1\|3001912_3003628_-\|adenosylhomocysteinase	gnl\|CDD\|235488	PRK05476, PRK05476, S-adenosyl-L-homocysteine hydrolase; Provisional.	1.2879e-108
NZ_CP009755.1\|WP_066656516.1\|3014490_3014985_-\|HNH-endonuclease	gnl\|CDD\|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	9.55064e-19
NZ_CP009755.1\|WP_066658729.1\|3000518_3001868_-\|amidohydrolase-family-protein	gnl\|CDD\|238637	cd01312, Met_dep_hydrolase_D, Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	6.23736e-77
NZ_CP009755.1\|WP_066656523.1\|3016600_3017296_-\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	5.48051e-43
NZ_CP009755.1\|WP_066656513.1\|3010154_3011594_-\|argininosuccinate-synthase	gnl\|CDD\|235434	PRK05370, PRK05370, argininosuccinate synthase; Validated.	0
NZ_CP009755.1\|WP_081985333.1\|2999997_3000495_-\|cupin-domain-containing-protein	gnl\|CDD\|377622	pfam06172, Cupin_5, Cupin superfamily (DUF985). Family of uncharacterized proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.	6.57195e-50
NZ_CP009755.1\|WP_066656511.1\|3008537_3009674_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	6.89383e-56
NZ_CP009755.1\|WP_066656519.1\|3015362_3016310_-\|C40-family-peptidase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	4.67738e-30
NZ_CP009755.1\|WP_066656489.1\|3003762_3004026_+\|glutaredoxin-family-protein	gnl\|CDD\|239274	cd02976, NrdH, NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase activity that is dependent on TRX reductase, not glutathione (GSH). It is part of the NrdHIEF operon, where NrdEF codes for class Ib ribonucleotide reductase (RNR-Ib), an efficient enzyme at low oxygen levels. Under these conditions when GSH is mostly conjugated to spermidine, NrdH can still function and act as a hydrogen donor for RNR-Ib. It has been suggested that the NrdHEF system may be the oldest RNR reducing system, capable of functioning in a microaerophilic environment, where GSH was not yet available. NrdH from Corynebacterium ammoniagenes can form domain-swapped dimers, although it is unknown if this happens in vivo. Domain-swapped dimerization, which results in the blocking of the TRX reductase binding site, could be a mechanism for regulating the oxidation state of the protein.	1.68236e-18
NZ_CP009755.1\|WP_066656526.1\|3017461_3018580_+\|phosphoserine-transaminase	gnl\|CDD\|130433	TIGR01366, Putative_phosphoserine_aminotransferase_PSAT., phosphoserine aminotransferase, putative. This model represents a putative variant form of the serine biosynthesis enzyme phosphoserine aminotransferase, as found in Mycobacterium tuberculosis and related high-GC Gram-positive bacteria. [Amino acid biosynthesis, Serine family].	0
NZ_CP009755.1\|WP_081985101.1\|3018649_3019333_-\|DUF3027-domain-containing-protein	gnl\|CDD\|378605	pfam11228, DUF3027, Protein of unknown function (DUF3027). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.24938e-20
NZ_CP009755.1\|WP_066658732.1\|3012323_3013427_-\|epoxide-hydrolase	gnl\|CDD\|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	3.5807e-34

>NZ_CP009755.1|WP_066656511.1|3008537_3009674_+|AI-2E-family-transporter
MPLFGNHPATSDATPGPLARKWTDGFGSLATRCLQVIVVLVIAIGIVYAAATLSVVTIPVLLALIIASAMHPVVSWLRRHKVPSVLATLAVLLGVLVVLGLVAWLIVVAVISQWPDLQKSAISGFQQLQDTVAHLPFSISDQQVDQVVNGVQDFLTSSQFGSGALAGASATANFLTGLVLMIVVLFFFLKDGPAIWEFLLRPFTGARYERARRVGDRVVQTLGGYVRGTASVAAVDAIGIGVGLAIVGVPLALPLAVVVFITAFIPIVGATAAGILAALVALVANGPVAALIVVGIVVLVNQLEGNLLQPVLMGKTLKLHGLVILIGLTAGTVLAGITGAIISVPLLAAAWGAVQVWGGPDRPAEPWRQKRPETAERR
>NZ_CP009755.1|WP_158407773.1|3007717_3007885_-|hypothetical-protein
MHDHDTHPFDRHVGPPHVERFRLTRTDEMLRVVCTCAIGADHDNTIRHPAAPTVA
>NZ_CP009755.1|WP_066656508.1|3006813_3007641_-|ammonia-dependent-NAD(+)-synthetase
MRELQATIAADLDVQPTIDPEQEVARRVAFLRDYLTTTGAKGFVLAVSGGQDSTLAGRLTQLAVESLRAEGREAEFVTVRMPYRVQADEDDAQLALQFIAADPGIVVNIEHGVDGVVQDTAASGVALSDFVKGNVKARMRMVAQYAVAGQRGLLVVGTDHAAEAVTGFFTKYGDGGVDLTPLTGLTKSQGRQLLEHLGAPARLYEKAPTADLLDDLPGQTDEANLGLTYVEIDAYLQGHDVPDEVAEAIESRYRATEHKRRVPATPFDSWWQQGA
>NZ_CP009755.1|WP_066656505.1|3005129_3006578_-|flotillin-family-protein
MEVLLALGAVPLVIVGIIVLAVIALVYAKLVYRNAGADEAIIITGKRSRKVKNPDGTETVESGIKVVLGAGVLVRPFFERVAKISLSSRAIDINVNAQDSRGVTIDVEAVALVKVGEADASIRAAAQRFLGQEKKIDDFAREVLSGSLRASIGATDVSTIIRNRDQLTVAVLDVAKDALHSQGLDVDSFEIKGISDRNDYISDLGRAERARVRLEAENAEAQADREAREARATADQAIAEAENTLAIRRAALQLDADRASAEAAAAGPLAQARASQGVVEQEQITAQKRAELRRAELESEVSAVAEANARKTRVEAEAAAAAQVETARAQAEARRISAEAVAAEAQAEAAARKLAADASRAEGEAAADAIRAKGQAEADATKAQADALAQHSEAVLRVKALETLPSIARELAAPMGNIDKLTVVSSDGAGALSKSVVSQFSEVDALLGTTAGFTLSDIVKSTTTGQAAARAVAREQDAAPVD
>NZ_CP009755.1|WP_066656496.1|3004596_3005097_+|hypothetical-protein
MTDENERPRPEDDAARLGLVVVGEAAALHAGDDASLDASEANIRETVDSMVDEPLTPRQEEVMERLAAAGGTLTAGLSGALAAKTGGQVEDVLEGAARSVVWQQRLAAERDALQGRPQESTDGDPVTDGDPVTDGDPATDSDPVEDQREDAGGQQRHRDDDGRDRG
>NZ_CP009755.1|WP_066656492.1|3004151_3004427_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MLGLIISLIIIGLIAGALARLIIPGKQHMSILMTIVLGIIGSFVGGFLGFLIFQHDPMDGFFQPAGIIGSIIGAVIVLFLYTRFAGRGARR
>NZ_CP009755.1|WP_066656489.1|3003762_3004026_+|glutaredoxin-family-protein
MTDATFDKVTMFGADWCRDCRRSKALLDRLGVDYDYVDVEADLSAADRAEAISGRKNIPVVVLPNGKHFVEPSDTELQAELESSGAV
>NZ_CP009755.1|WP_066656486.1|3001912_3003628_-|adenosylhomocysteinase
MPQRPDPERAAWAAAAVRRFAAATNLLVAGRTVRVLGGDPRDAAALVALLTGLGARTAADPAPADHEPVDDEPIDQLWCLGDPDESTAAVERETDRPRGATLVVVDAGRYAPAVDEDAFGPVAPARPGVLAVPTLSDDVFLVSTGREPEDDPAAEDRIRWARRSMPVARAVAAELRDGGLLRGTRIGVAMVLEPKTAVLSLLLRDAGAEVVVYAHADETDDAVADVLRRAGMPVHADSTASLAEQHRLALAMLDTRPHVLLDDGSHLIRLAHQERPELLPTMLGAAEETTSGLRPLRVMAERGELGIPVVAVNDARAKTCFDNRFGTGQSTVFATLDLVDPLPSAVHRVRPGGTAVVAGFGPVGEGVAQVLVALGFRVTVAEVDPVRALQARFAGHAVAPFVDAVRDADLVVSASGVADTVDHTVLRACAVGAVVSVAGGVDDEVALSAAASAGAVRTAVAQHVERLTWPDGHQVLVLAGGNGVNTSAAEGNPVEIMDLSFAVQLGALRMLLERGDELPRAVVPVDPAVDEATARVALAAWGSRVAPPVRIAEQPADRERDVRTHRFGTPR
>NZ_CP009755.1|WP_066658729.1|3000518_3001868_-|amidohydrolase-family-protein
MTAPPIADGAVAVQDGRILHVGDRSWVVDQLDAAGRTCTERRWRGALLPGLVNAHTHLQYTGMSGVGQRQYAGFEDWAAAFNVDYALPHDWRAEASAGAVASIAAGVTSIADVVTDIEAADVLEQHRLGGIAYWEVMDWENAAWESHGRDQVLDELARIPTTPGAGLSPHAPYSLDVAPLLELPDIVRQRGLRLHLHLGEAAFEGERVSLGPVPGLEGVDGVGHTADWHLANVPSFRAMRALGFGASATAFVDRLGVLGPDCHIAHGVYVTASDRALLRARGTTVALCPRSNAVIGLDPPPVADYLREGSPIAIGTDSLSSSPSLDPMADVTALHRIARAQGYAHRDLHERLLAAATLGGAHAMGTAVGPDRVGHLAVGARADLAVFDVDARTVPDALAELVEDGAGRAVATIVRGVVRATDGTVHPLDPETAPTRGPVPHHVRPQEER
>NZ_CP009755.1|WP_081985333.1|2999997_3000495_-|cupin-domain-containing-protein
MVARRTVGGELIEWLDVPQRAAALGMEPHPEGGWYVRTWTSPSTVETPAGERPAATLIHFLLPPGEASAWHRVTSDEIWMWHGPDTVVLELGGSGDRPEPGDRITLGPDAGRHRLHDAQAFVRGGVWQRTLPGDGEVLLSCMVSPGFSFDDFTMAGDTDGDAATA
>NZ_CP009755.1|WP_066656513.1|3010154_3011594_-|argininosuccinate-synthase
MSKVLSSLPVGERVGIAFSGGLDTSCAVAWMREKGAVPCTYTADIGQYDEPDIDAVPGRAKEYGAEIARIVDAKSALVEEGLVALQTGAFHIRSGGKTYFNTTPLGRAVTGTMLVRAMKEDGVDIWGDGSTYKGNDIERFYRYGLMANPRLRVYKPWLDTEFVEELGGRKEMSEWLVARGFPYRDSTEKAYSTDANIWGATHEAKSLEELSSGLDIVEPIMGVAAWRDDVVVATEEVSVRFEAGRPVAINGVEYADAVALVYEANAIGGRHGLGASDQIENRIIEAKSRGIYEAPGMALLHIAYERLLNAIHNEDTVAAYHNEGRRLGRLMYEGRWLDPQSLMLRESLQRWVASAVTGEVTLRLRRGDDYTILDTTGPALSYHPDKLSMERVGDAAFGPDDRIGQLTMRNLDIADSRSRLEQYAAAGLIGGATGELVGELQSGEAEEILGGAVVSSEDEALGRATDAASEGAAFDSGTD
>NZ_CP009755.1|WP_144411381.1|3011740_3012064_-|hypothetical-protein
MTSIDNHRQTIAAAVFQVRLGDFKASEVALTAAIEDVVRSVLAGHAPAGAASAEFRASAEKHFVFFTSDRSSLEYDDENLMWQLEADIEHLLGQEMYGRLRGASVAL
>NZ_CP009755.1|WP_066658732.1|3012323_3013427_-|epoxide-hydrolase
MSETPVIDDATIGDLRVRLRATRWPDAPAGTGWSLGVDVDELRSLVEYWADGFDFDGHREQLAALPSERHVVDGVRVHVLHARSGRPDALPLLLAHGWPDSGWRYRKVLPMLVEAGFDVVVPDMPGYGFSDAPPRVLDAREVAGMWATLMTDLGYDRFAASGGDIGTHVVRYLALDHPDRVVAVHRIDGGLAWPGIDTTELSPAERAFVQETERWRTAEGAYAVMHRTKPQTAAVGLTDSPAGLAAWIVEKLRSWSDCCGDLWSVYTQDEVLALLTEYWATATIGSSMRMYHANAAIPAAQLRRRVEVPSGFSVFPGDIVRAPREWLERTTNLVHHHELDRGGHFAPFEQPELFVDEVCAFLEPYRR
>NZ_CP009755.1|WP_066656515.1|3013437_3014274_-|pentapeptide-repeat-containing-protein
MTSSSFPGPDRADLRADCGSCAALCCAAFGFTRSADFPVDKAPGDPCRNLADDFSCTVHESLRPRGYRGCTVFDCAGAGQRVTGQLYGGVDRHQRQDVRVEMFAVFRVVRQLHDLLWYLAEGAVRRFQPEASAALVERIEDAIGQGPTVVLGLDLVGLHEEVRAVLVEVSAEVRGGYATVLPAVLSPGADLMGRRFHGVSLCGADLRGAYLIGADLSGADLDGVDLLGADLRGARVHGADLSGSLFLTQMQVNAAQGDERTRLPVDVVRPSHWGSGGA
>NZ_CP009755.1|WP_066656516.1|3014490_3014985_-|HNH-endonuclease
MRTLVLNAGYEPLAVISDRRALVLVMNQKAAVIAADLDHPVSGSSASFDRPSVIILTRYVRIPHARLVPVSRRGVLRRDANRCAYCDRHATTIDHVQPRSRGGQDSWENLVACCLACNNTKGDRTPQEMGWRLRFRPKAPHGASWVVRGIERPQSEWDEYLVAA
>NZ_CP009755.1|WP_066656519.1|3015362_3016310_-|C40-family-peptidase
MTQTGSAADDQTPANPTNTANDAPLTRRAARQTEAPARRITPVRDAPLPGGRRAAQAARAAETAKASSSARKRRFLAPVVLTVAAGMFGTVAVAPAFAATQQTGSTAADAQRQVRTTQAQQFSVSDAVALAGTSRDGYGATAQSTLDAEAAQKAAAEQAAAAQAQAAATQAARAQTAKQYSSYSGPSANEIATTAAAANTPFSLPAVVATAKQYIGTPYVFGGADPSGFDCSGYIMYVYAQYGISLPHSVPLQDAAGTTIPESQAQPGDVVIFNDGSHDGFYMGNGMIMDAPKPGGSVSIRPIWTSSYHIVRFGI
>NZ_CP009755.1|WP_066656523.1|3016600_3017296_-|metal-dependent-transcriptional-regulator
MTDLVDTTEMYLRTILDLEEEGIVPLRARISERLGHSGPTVSQTIARMERDGLVVVSGDRHLELTGEGRSRATHVMRKHRLAERLLADVIGLDWAFVHDEACRWEHVMSEQVEVRLLEMLGNPTESPYGNPIPGLAEIGGPTAGQFLDGVQNIVAATDGTDAVAVGVVRRLGEPVQFEPELLHQLRTAGVMPGRVARVQRAGAYVAVRVDGEDAGIELPTEVAQHVYIERD
>NZ_CP009755.1|WP_066656526.1|3017461_3018580_+|phosphoserine-transaminase
MADIVIPAELLPTDGRFGCGPSKIRGAQLESLVTRGATILGTSHRQKPVKDLVGSVRRGLADLFQLPDGYEVVLGNGGSTAFWDAAAFGLVERRAENLSFGEFGSKFAKATDTPWLETPHVVEAPGGSLAALEPVEGVDVYAYPHNETSTGVMAPVVRAAGDDGALTVVDATSAAGGAAFDVAATDVYYFAPQKNFASDGGLWLALFSPAAIERVERIAASDRYIPEFLSLQNAVDNSRLDQTLNTPALATLLLLDDQVDWINQSGGLAWADTRTKTSSSTIYDWAEASDHATPFVTDPAHRSQVVATIDLDESIDAKAVAATLRANGIVDTEPYRKLGRNQLRVATFTAIDPDDVAKLVRAIDFVIGELRG
>NZ_CP009755.1|WP_081985101.1|3018649_3019333_-|DUF3027-domain-containing-protein
MVDHTELARKALLEVTPESTVGQPVGTVDEGDGVVSVLFSNRMPGYPGWRWTVSIAQVEGDEPTVLEVELMPGDGSLVAPDWVPWADRMAEYRAGQADEDVDDESDDEDDDESDEDDDLDDAEESDYDDPDDDEADDDASDDDDDEFEDDEDDLAESDDDELDGVDVDAADDDSDDDAADDVAEDPAPVRSRGSRRRASRVRPTDPDQDLELDRLDPSETDPERHGA
>NZ_CP009755.1|WP_066656529.1|3019332_3019710_-|cold-shock-domain-containing-protein
MPTGKVKFYDDQKGFGFITGDDGEPVFLHASSLPDGVTSVKAGTRLEYGVVQGKKGSQALSVRLLEPAPSLAKMSRRSADDMAVIVEDLVKELDRVSGDLRHGRYPKNGERLAAILRHVADQLDA

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Crispr_ID: NZ_CP009755_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP009755_10

3132609-3132685

Orphan

Consensus_repeat	Method
CGGACGGGAGGCGCGGGGCGGACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP009755_10

>merge|NZ_CP009755|10|3132609-3132685|CRISPRCasFinder
CGGACGGGAGGCGCGGGGCGGACCGTCACCGTGCCTCCCGGTCGACGGACGACCGGACGGGAGGCGCGGGGCGGGCC

>NZ_CP009755|10|10|3132609-3132685|CRISPRCasFinder
CGGACGGGAGGCGCGGGGCGGACC	GTCACCGTGCCTCCCGGTCGACGGACGAC
CGGACGGGAGGCGCGGGGCGGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP009755.1\|WP_066656827.1\|3128474_3129317_-\|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223461
NZ_CP009755.1\|WP_066656825.1\|3126749_3128114_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270453
NZ_CP009755.1\|WP_144411386.1\|3132168_3132597_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066656843.1\|3137331_3139155_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP009755.1\|WP_066656841.1\|3134958_3135381_-\|DUF805-domain-containing-protein	unknown	unknown	gnl\|CDD\|377540
NZ_CP009755.1\|WP_066658760.1\|3135412_3137206_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP009755.1\|WP_066656821.1\|3120227_3121187_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP009755.1\|WP_066656823.1\|3121603_3124732_-\|alpha-mannosidase	unknown	unknown	gnl\|CDD\|223460
NZ_CP009755.1\|WP_066656817.1\|3118471_3119356_-\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576
NZ_CP009755.1\|WP_066656846.1\|3139754_3141413_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_CP009755.1\|WP_066656819.1\|3119345_3120086_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP009755.1\|WP_081985112.1\|3125695_3126646_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP009755.1\|WP_066656848.1\|3141409_3142003_-\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|235544
NZ_CP009755.1\|WP_066656829.1\|3129455_3132008_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376421
NZ_CP009755.1\|WP_066656850.1\|3142013_3142850_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NZ_CP009755.1\|WP_066656837.1\|3134111_3134567_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP009755.1\|WP_081985110.1\|3124793_3125693_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP009755.1\|WP_066656834.1\|3132762_3134013_-\|ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
NZ_CP009755.1\|WP_066656839.1\|3134573_3134954_+\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|226219
NZ_CP009755.1\|WP_081985116.1\|3142950_3143919_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|226674

Protein	Function_ID	Function_description	E-value
NZ_CP009755.1\|WP_066656827.1\|3128474_3129317_-\|PhzF-family-phenazine-biosynthesis-protein	gnl\|CDD\|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	2.67731e-59
NZ_CP009755.1\|WP_066656825.1\|3126749_3128114_-\|extracellular-solute-binding-protein	gnl\|CDD\|270453	cd14750, PBP2_TMBP, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose; possesses type 2 periplasmic binding fold. This group represents the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.67906e-86
NZ_CP009755.1\|WP_066656841.1\|3134958_3135381_-\|DUF805-domain-containing-protein	gnl\|CDD\|377540	pfam05656, DUF805, Protein of unknown function (DUF805). This family consists of several bacterial proteins of unknown function.	1.35783e-20
NZ_CP009755.1\|WP_066658760.1\|3135412_3137206_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.88385e-163
NZ_CP009755.1\|WP_066656843.1\|3137331_3139155_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.25006e-145
NZ_CP009755.1\|WP_066656823.1\|3121603_3124732_-\|alpha-mannosidase	gnl\|CDD\|223460	COG0383, AMS1, Alpha-mannosidase [Carbohydrate transport and metabolism].	1.3058e-146
NZ_CP009755.1\|WP_081985112.1\|3125695_3126646_-\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	3.59478e-71
NZ_CP009755.1\|WP_066656817.1\|3118471_3119356_-\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	3.82776e-55
NZ_CP009755.1\|WP_066656846.1\|3139754_3141413_-\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_CP009755.1\|WP_066656819.1\|3119345_3120086_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.29193e-36
NZ_CP009755.1\|WP_066656837.1\|3134111_3134567_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.44364e-10
NZ_CP009755.1\|WP_066656848.1\|3141409_3142003_-\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	2.49702e-84
NZ_CP009755.1\|WP_066656829.1\|3129455_3132008_-\|hypothetical-protein	gnl\|CDD\|376421	pfam00932, LTD, Lamin Tail Domain. The lamin-tail domain (LTD), which has an immunoglobulin (Ig) fold, is found in Nuclear Lamins, Chlo1887 from Chloroflexus, and several bacterial proteins where it occurs with membrane associated hydrolases of the metallo-beta-lactamase,synaptojanin, and calcineurin-like phosphoesterase superfamilies.	5.78129e-15
NZ_CP009755.1\|WP_066656850.1\|3142013_3142850_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	2.36933e-49
NZ_CP009755.1\|WP_066656839.1\|3134573_3134954_+\|DNA-binding-protein	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	4.62001e-18
NZ_CP009755.1\|WP_081985110.1\|3124793_3125693_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.6583e-61
NZ_CP009755.1\|WP_066656834.1\|3132762_3134013_-\|ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.62718e-40
NZ_CP009755.1\|WP_081985116.1\|3142950_3143919_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	1.67809e-86

>NZ_CP009755.1|WP_144411386.1|3132168_3132597_+|hypothetical-protein
MTDDTSNTALQSMIERAGQITAEEAEALDVVWKADEQIVVPEASASLAIQGGADGRMVTNADLLAAWKHALDAAGEAGRVDEIEAAQEAGKAVKHGGAHLRDRAGAEEAVRSAVLATGVRDLLTDEEYDTLTAAWRRVFGAA
>NZ_CP009755.1|WP_066656829.1|3129455_3132008_-|hypothetical-protein
MHTPALRLGAGLATGIALAAGVLTATPAVAAVGDDDPTVGARVTTGPAAGLAINEVESNADDTDWVELVNTSSAAIDLSGWRFLDSDSSHTAYTLPQGSTIAAGGYLVVDQETTTRSGFDFGLGGADSVRLYDASGTLTLRYAWTTHAAVTYGSCPDGSGTLVDTTASTKGGPNDCSSPVRINEVESQGGTPGDWVELTNVGTTTVDLGGYVLRDGEDDHAWTVPAGTTVAPGGFTVLDEAQAGADADTAPGAGAETGTGTGAGAGFGFGLGKADRVRLSDARGVLVDEYSWTAHAATTYGRNPDGTGAFAETAEPTKGSTNRFAGVVTAEAWPGGPDETVLDAEDTFTGDLSGLDWTSSASSQDGQLWAVQNGDGLLYHLVPDGRGGWAPTNTAGVDLRYADGTGTPDAEGVTVTADDPGAVYVSTERDNDVSKVSRPAVLRFATTDGSESVLRATDEWDLAADFPGLGANAGLEGVTWVPDAWLTSRGFVDQHTGATYAPAAYPGHGEGLFLVGVEGTASVYAYALMDDGSSQRVATIAAPFSLVAEVQFDPTLDALWVVCDEACSGRTALFDVQDGAFTLATLYEAPANADRTLANEGFAISGRCVDGARATFYADDNDTNGASLRAGTYPCDAVEEPGDGDGDGGAPAPGDGETPAPGGGETPAPGDGGDSTPAPGTGGSSPAPVPTTPGPTTPGPTAPGPAAPAAPVAPDVSALVDGNRASVSAPSNVRAGSSLTIDVGTRYAGQRVAVWLFSEPRLLGTPVVAADGAVTVAVPADVPAGQHRIAVVAFDGTVLGWTGITIDPATGSLAFTGAELGGGIAAALLLLAAGAGVLVARRRRTVGSPA
>NZ_CP009755.1|WP_066656827.1|3128474_3129317_-|PhzF-family-phenazine-biosynthesis-protein
MRSEVLRYTAFAAEPGGGNPAGIVLDAEGMTDDEMLAVAQEVAYPETAFVVARTPDGARVRYFSPAAEVPFCGHATVATAVVLAEREGTGARVFSTAAGDIAVDATTAPDGSVQVAMTSVEPSTRPIDPVRWERLAAVLGLVDGDVAEGFPVLESSAGNRHPVVVLADVELFHQFRFDPAALAALKREYGWEGTVTVLHRTGPLEFEARNLFPAGRITEDPATGSAAASTGAYLRAVGAVSPGARVVIRQGRHVGRPSVLLVDVPESGGITVTGGATPIA
>NZ_CP009755.1|WP_066656825.1|3126749_3128114_-|extracellular-solute-binding-protein
MKRRTRIIAGLAAVAAAAVGLAGCSSSGSASSDTIKIAYQKFGAFQQLDAQMKVVKQEYEKANPGKKVELVPIQAQEDDYATKLALMNRAPATAPDVIYEDTFRIKADADAGYLLPIDQYTEKWDEWDQFYDNAKQAGEGEDGKIYGVPMGTDTRALWYNKDIFEKVGLPVPWEPKTWDDVLAAAKTIKEQDPDVIPFNIYSGKAQGEASTMQGFEMLLYGADGDGNTLYQDGKWVVGSKQFEDSLQFIEDVYQGDLGPTPQQALDTNIGTTITQTWLPEGKLAIDLDGSWQSGTWLETGTAPWKEWNDVMGQAPFPTQNGQEPGYNSMSGGWTLSVGAKSKDPQAAFDFITMFLDKDGSIKYDAENSQIAVRKDVAEDPEYTGANPTFEFFSGLVEHTNFRPATSEYAQVSNAIQVAMESVMTGQQSPSEAAAVYDKAVEGVVGKDGTVAAGQ
>NZ_CP009755.1|WP_081985112.1|3125695_3126646_-|sugar-ABC-transporter-permease
MSSTPLAPTLSAPGAPKRTEPPVPRKRRPLRNATRVVPLLPAVVLLVIFLLGPVISSFYGSFTNAALTGVDAANQQFVGFQNYVELFQDPDFPKSVVLTIVFLLASAVVGQNVLGLGLALLMRSANKVVRAVVGTFVVAAWVLPEIVASFAAYAFFHDEGTLNSFLASIGISGPNWLYTYPMIAVILANVWRGTAFSMLVYSAAVQEVPEEITESAEVDGATGWQRLVYITLPVIRRSISTNLMLTTLQTLSVFTLIFVMTGGGPGTNSSTLPILAYQEAFQFSQLGFGTAIATILLVVGAVFSIIYIKALKPEVD
>NZ_CP009755.1|WP_081985110.1|3124793_3125693_-|carbohydrate-ABC-transporter-permease
MALTADRPVSDTTRSVTAPGALHMTSPRGRTLRWVSNIVLLVIAVCFAVPLLWLVLASVDAQASLSVKIPSQFTLDNFTQVLTPELSFIPLANSLLLSGGTAVVTVVAALLAAYPLSRYKMRVNKPFLYSILFGTGLPITAMMVPVYALFVSLNLIDNIYGCIFFLAATSLPMAIWMAKNFMDSVPISLEEAAWTDGASMFTTLTRIVVPLMRPGIAVVFIFVFIQAWGNFFVPFVLLLSPDKVPAAVSIFNFFGQNGAVAYGQLAAFSIVYSVPVIALYVLVSRGLGGGNALAGGIKG
>NZ_CP009755.1|WP_066656823.1|3121603_3124732_-|alpha-mannosidase
MHHDEPLVEARIARLVRDRIDPAVHRRSAPVTVDAWQVPDEPVPFAEAVAAEYTPFRVGDAWGARPWGTTWFRVRGTVPDDFGVDPGTTVELRVDLGFSKRQPGFQAEGLAWRTDGSTIKGIEPRNDTVPVEVGPGGTFEVYVEAAANPDIGGDDFQGATPLGSKTTAGTEPIYRLRALELVERDDTVWELQQDVWVLRGLMAELPTDGTRGADILRGLERAADALDPDDVAGSAAATREVLAPLLAVGAAGSAGRAVAVGHAHIDSAWLWPVRETIRKCARTFSNVLDLMDQDPDFTFACSSAQQYAWIRDGYPSIWARIKQRVAEGRWIPVGGMWVESDTNLPGGEALARQFVAGKRLFLEEFGIDTPEAWLPDSFGYTGALPQIVRAAGSKWFVTQKPSWNETNVIPHTSFHWEGIDGSRVLTHLPPADTYNSDVSAADLHRGERGNKERGVANTSMLLYGFGDGGGGPTREMVAAARRQHDLDGSPRVDLGTPAQVFEELERVLPEPAVWSGEMYLEFHRGTYTSQIRTKQGNRRSEHLLREAELWAATAAVRLGAEYPYDELESVWHTVLLQQFHDILPGSSIAWVYENAEAEYARVAEVLEDLIGASTTALASGGAPALAGVGASATAFAGDGGAPLDAPRGPGAAGTGGSAEGGTVVRFNASPVAAGGVTALGGSAASATEAVPPVRSGDCFVLDTGVVTATVDAEGHVVSFVDHATGRDAIAPGAAAAQYTVFRDTPNQWEAWDIDRAYQRSGTVLAAASVEVVGDALVVTRPFGSSSVTTRYSAVAGQPELHVETEVEWHEQQKLLKLAFPLDVRASVASSEIQFGHIDRPTHQNTSWDMARFETAAHRWVHVAEPGFGVAVANDSTYGHDITRSTRADGGTTTLVRESLLRAPTFPDPHADQGHHVFRTVLRVGESVLDAADSGYRLNLPVRSVPGSGSADVSPLVVVSSPQVLVEAVKLAEDRSGDVVVRLYEASGGRASDVGVSFGFDVASVEAVDLLERPLGSGTWAAGEPVVLTLRPFEIVTLRVRRA
>NZ_CP009755.1|WP_066656821.1|3120227_3121187_-|hypothetical-protein
MERPLPILRAGPAREIACDPTTLRRRARSSGADRLIRVGPNAYVEGARWDAAGPRQRYVTRVHARLGRIGTAAVASHVSAAAVLGLPALGGWQVPVHATVPETMYRGRTRDLVLHTRPVRGDELLAADGIRVTTVPRTVVDIAMQDDLRTAVVVADAAVRAGTGAAELLAAVDPRARGHRRAEHVLGLADGRAGSVAESFARVVFLELGLPGPVLQQEFVVGGRRFTVDFWFPDQGVVVEIDGRAKYTQERYLAGRSPTEVFLDEKRRHEQLLTVPGVRTIVRLEWRDLFDPDGLVRRFRAAGLPCPVRPSRSARPGAA
>NZ_CP009755.1|WP_066656819.1|3119345_3120086_-|histidine-phosphatase-family-protein
MAVTEIWLVRHGESTANVAAARAEAEGADVIEVDHRDADVPLSPLGEEQSRALGQELADRGVDDVPVALWVSPYRRAQQTIGIALEAGGLTEPPKRVDERLRDRELGVLDLLTRDGVRNRYPDEERRREWLGKYYHRPAGGESWADVMLRLRTVLTDVDRLEGTERLLVAAHDAVVMLAVAVCLDLDEHALMAFAEDHTVANASLTRLHRDGPGAPWTLEEFSAVGHLDDDEVTEHSGRKDDARVD
>NZ_CP009755.1|WP_066656817.1|3118471_3119356_-|NAD(P)H-hydrate-dehydratase
MSTDQEPAAPQHITPNVLREWALPDPGAGKYGRGQVLVVGGAAHTPGAAMLSALAALRVGAGRLSLAVGSSVANQVAVAVPESGVVPLAEDDGGHVAVGAIDAVLDTAGAADAVLVGPGLDEPDGARDLVAGIADAVGPDTFVVLDAFALGVAADVEDRLRPLRGRLVLTPNSGEAERLLGRDCGDDDVADAREIAERYGAVVALSDVIAAPDGRAWVKGTGSGGLGTSGSGDVLSGVVVGLLARGAEPAQAVAWASYVHAAAGDRLAVQVGPLGYLASELLTEIPRVLVELGG
>NZ_CP009755.1|WP_066656834.1|3132762_3134013_-|ROK-family-transcriptional-regulator
MAEHRRGANLPSIGGFNRTVVLDAVRRSPDGLSRVELAASTGLSAQTVSNVTRFLIEAGMIVESGTVVAGRGKPRTILRLEATSRYAVGVHVDPAVVTYVLLDLAGSVVAETTTSTPSADDPAEVVRTIATAVDGLVADAGVAAESVLGVGIASPGPIDVDAGVVLDPPFLPRWRDVPLRDALAEATGFPVLLEKDVTAAVVGEMFLAGESSARNFAFVYFGTGFGVGLVVDHEPVRGTGSNAGDAGHIMVDQGALAGTPDGSGPRGEVGAAVAPARLVEVARDRGLRLPGAARADDVTAVQRAWDSLGEAIASGDEVASGLAADAGTVMGRAVVVIVNLLDVDRVVFGGPFWSRIAPVALPAARAAITGSPLLVPKHPIAVVDSGRGADVAAVGAACLVLDAALSPRASALLIRR
>NZ_CP009755.1|WP_066656837.1|3134111_3134567_+|GNAT-family-N-acetyltransferase
MTDLRLEALSASTAAAANSLTLKPGQEQFVQPTTYGVAESDVKPSSAWTRVVLDGDRVVGMIIGTFDEDNNEEELRSAIWRVNVAADAQGRGVGRFAVHGLADEARSRGFERLTVVYEPGGHGGPEAFFRALGFEVVRETQYGDHYAVLAL
>NZ_CP009755.1|WP_066656839.1|3134573_3134954_+|DNA-binding-protein
MDGAESGPEPDSGAEPDFGAAVAEVVRLIPAGHVMTYGDVAAVLGSRAARAVGTVMAREGADLPWWRVVRAGGLPPVRHEARALEHYRAEGTPLVERSSAASGSSAWRIDVRRARWSPATDADDPF
>NZ_CP009755.1|WP_066656841.1|3134958_3135381_-|DUF805-domain-containing-protein
MSNDSVQPGGVALRDPFYGAPFAEAVRRFWRKYTVFTGRASRSEAWWWWLTSFVIGLVLQLVPQVFTPGTPVLENPVGSYLFVLWGLATLIGSLALGARRLHDANLSGFWQFLHVVVGIGSLVLLVMFLLPPNPKGSRFD
>NZ_CP009755.1|WP_066658760.1|3135412_3137206_-|ABC-transporter-ATP-binding-protein
MRGEEREDFSKAESKRLRRRSLALLGSLAAPLKARLVLLGVVVVVSTAGTVAGPALIAWGIDNALPRVMDQNDWVPAFGVVATYIVVAVLGAVLTAWYTVLAARISQAILFDLRKRVFLHTQRLSLEFHETYTSGRIISRQTSDLDSIRELLDSGLNQLIQGVLYMVFTGIALVLLDPTSGLVLAVSLVPLWFLIRWFQTNSQTLFRATRVTSARVIVHFVETMTGIRAVQAFRKESRNRDEYGGYVEDYRVANTKVFNLFGTFDPVLVLIGNATLAAVVIVGGFRIVGGSLEVGALLAVALYAKRFFDPAQELAMFYNGYQSASAAMEKISGVLEERPSVPDPAKPVRLPDATGAMDFDDVEFAYNAEKVVLPEFDLHIPAGQTIALVGSTGAGKSTLAKLMARFYDPSKGSVRLDGVDLRDIDPKDMRRAIVMVTQEAYLFSGSVADNIALGKPGATRDEIVRAAKAVGADAFIEALPDGYDTDVNKRGGRVSAGQRQLLSFARAFIADPKVLILDEATASLDIPSERLVQEGLETLLADRTAVIIAHRLSTVAIAHRVLVMEYGRIVEDGTPDDLIAGTGRFAQLHAAWRDSLV
>NZ_CP009755.1|WP_066656843.1|3137331_3139155_-|ABC-transporter-ATP-binding-protein
MSTTPDQATPSTDRPSTLRAIGRIWPYVRPYRWRLFGGMAAAMGASLVALVIPYVLQWLVDGPLSSRDAALIWPAGLGVLALGALEAFFIASRRRLVMRPSTRIETSMRNALYAKLQDLPVAFHDRWESGQLLSRSVSDLSLIRRWLAFGVVLLVVNIVTIAVGFVVLFTFGWLLGLIFLVASIPLWINGLLFERKYSVVARRSQDQVGDLATSVEQSVHGIRVLKAFGRGRFKLDEFSEQAEALRGTEIEKAKAIASIWLWLLLVPDVAFALCLLAGIWLASQGELTVGQLFAFFATATVLRFPIESIGFFLSMTFDTRTAVDRFFEVMDSENTIQDPASPRTIDEPHGALSFNAVHFRYQDATDEYPDLVDGVELQLHPGETMALVGLTGSGKTTLLSLVPRLYDVTGGSITIDGVDVRDLTRADLRRHVGVAFEDATLFSTSVRDNVLLGRPDLEGAEAERIMREALDIAQASFVDDLPEGVDTRVGEEGLSLSGGQRQRLALARAIAARPSVLVLDDPLSALDVDTEARVEAGLRRVLADTTSLIVAHRPSTVTLADRVALMEGGRITAVGTHSELMATNEHYRYVISSLDEDDAPAREEAMA
>NZ_CP009755.1|WP_066656846.1|3139754_3141413_-|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MSVHAADPSLYRHRDVVPVRRALISVSDKSGLLELAGALADAGVELVSTGSTAQTIRDAGYAVTDVSSVTGFPESLDGRVKTLHPAVHAGLLADLRLESHEQQLAELGIAAFELVVVNLYPFVETVASGAEAATVVENVDIGGPAMVRASAKNHPNVAIVVSPSSYAEVVEAVRAGGTTLELRKRLAAQAFAHTASYDAAVASYFATDVVGQDAAHVAAQAAAPTVTGDLETPGSFDETLRLEAGLTATLRYGENAHQAAALYTTSGGAGIAQATQLHGKEMSYNNYVDADAAVRAAYDFDTPAVAIIKHANPCGIATAPADAVDPIASAHAAAHACDPLSAFGGVIAANRPVTKQMAETVRDIFTEVVVAPAFDPEALEILSQKKNIRLLTLPADFALATREVKQVSGGFLVQDADRFTAFDQSTWTLVSGEPADAATLADLAFAWKASRAVKSNAILLADQGASVGVGMGQVNRVDSCHLAVDRAGERARGSVAASDAFFPFADGLQVLLDAGVRAVAQPGGSVRDDEVIAAAQAAGVTMYFTGERHFFH
>NZ_CP009755.1|WP_066656848.1|3141409_3142003_-|phosphoribosylglycinamide-formyltransferase
MLELVVLISGTGSNLRALLEATTDAEYPARVVAIGADRDAEGLALGEEFGVPTFSVPFSRFASRDEWGAELAAQIRPWSPDLLVLSGLMRLLPHAVVSEFAPAIINTHPAYLPEFPGAHGVRDALAAGVDQTGASVIQVDDGVDTGPILAQERIPVLPDDSESTLHDRIKPVERRLLIQTILDIANGTTDLKGTPSA
>NZ_CP009755.1|WP_066656850.1|3142013_3142850_-|helix-turn-helix-domain-containing-protein
MPSSSADLALGAYLRAIRGRLSPEALGLPSGGLRRVAGLRREEVAVLGGLSVDYYTRLEQGREISPGSAVLDGIADGLELEGDERDHLFTLAGLVPPPRRSRAPGSVSPALGQLLDSWSAHPAFVIDPAHDVLAANALARGVHAPFARFDNLVRMTFTDPVARDFHVDWSRTADSTVASLRAATAEHGADPGLLAVVAEVRGRSDEFEERWSAQRVQRKAVTTKRFVHGEVGGLEFDAHTFAVQGSPGLQLVVYGCAPGSATAQALPLLAIGGAVVRR
>NZ_CP009755.1|WP_081985116.1|3142950_3143919_+|SDR-family-NAD(P)-dependent-oxidoreductase
MNDDTPTTPHPYLGLWVTEDGRVRHELRTGGRYVEARGDREAAYTGGYEVAGAHVEYRDDTGFTADGDFRDDVLHHGGMVLRRRKIVLVTGASSGIGRATALRLASAGHPVVLGARRVDRLESLVTEIEGAGGQALAVPTDVTDLASTQAFADAATARFGRIDVVVANAGVMPLSPLSSGLVEQWDQMIDVNVRGLLHSIAATLPTMLAQGAGHFVTMASIGAHSVTETAAVYCGTKYAARAITEGLRLESPRGIRVTTISPGVTESELASTITDATAAAAMEAYRADSVSADAIARAVEYAVAERPDVDVNEIVVRPAAQR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP009755_1	1.1\|137287\|21\|NZ_CP009755\|CRISPRCasFinder	137287-137307	21	NZ_CP009755.1	2473657-2473677	2	0.905

1. spacer 1.1|137287|21|NZ_CP009755|CRISPRCasFinder matches to position: 2473657-2473677, mismatch: 2, identity: 0.905

ccgaacacgagcccctcgcgc	CRISPR spacer
ccgaagacgagcccctcgagc	Protospacer
***** ************ **

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP009755_1	1.1\|137287\|21\|NZ_CP009755\|CRISPRCasFinder	137287-137307	21	NZ_CP006369	Aureimonas sp. AU20 plasmid pAU20b, complete sequence	349834-349854	1	0.952
NZ_CP009755_5	5.1\|1347819\|35\|NZ_CP009755\|CRISPRCasFinder	1347819-1347853	35	MH045568	Microbacterium phage Kieran, complete genome	40743-40777	7	0.8
NZ_CP009755_5	5.1\|1347819\|35\|NZ_CP009755\|CRISPRCasFinder	1347819-1347853	35	MN062717	Microbacterium phage Sharkboy, complete genome	41274-41308	7	0.8
NZ_CP009755_5	5.1\|1347819\|35\|NZ_CP009755\|CRISPRCasFinder	1347819-1347853	35	NC_042099	Microbacterium phage Dismas, complete genome	40919-40953	7	0.8
NZ_CP009755_10	10.1\|3132633\|29\|NZ_CP009755\|CRISPRCasFinder	3132633-3132661	29	MH536815	Streptomyces phage Crosby, complete genome	34626-34654	7	0.759
NZ_CP009755_4	4.1\|1124683\|31\|NZ_CP009755\|CRISPRCasFinder	1124683-1124713	31	NC_021911	Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1f, complete sequence	825995-826025	8	0.742
NZ_CP009755_5	5.1\|1347819\|35\|NZ_CP009755\|CRISPRCasFinder	1347819-1347853	35	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	718077-718111	11	0.686

1. spacer 1.1|137287|21|NZ_CP009755|CRISPRCasFinder matches to NZ_CP006369 (Aureimonas sp. AU20 plasmid pAU20b, complete sequence) position: , mismatch: 1, identity: 0.952

ccgaacacgagcccctcgcgc	CRISPR spacer
ccgaccacgagcccctcgcgc	Protospacer
**** ****************

2. spacer 5.1|1347819|35|NZ_CP009755|CRISPRCasFinder matches to MH045568 (Microbacterium phage Kieran, complete genome) position: , mismatch: 7, identity: 0.8

cgaagccggtccgggacctcgaccgtgacagatgt-	CRISPR spacer
gggagccggtcctagacctcgaccgtgac-gacgcg	Protospacer
 *.********* .*************** **.*.

3. spacer 5.1|1347819|35|NZ_CP009755|CRISPRCasFinder matches to MN062717 (Microbacterium phage Sharkboy, complete genome) position: , mismatch: 7, identity: 0.8

cgaagccggtccgggacctcgaccgtgacagatgt-	CRISPR spacer
gggagccggtcctagacctcgaccgtgac-gacgcg	Protospacer
 *.********* .*************** **.*.

4. spacer 5.1|1347819|35|NZ_CP009755|CRISPRCasFinder matches to NC_042099 (Microbacterium phage Dismas, complete genome) position: , mismatch: 7, identity: 0.8

cgaagccggtccgggacctcgaccgtgacagatgt-	CRISPR spacer
gggagccggtcctagacctcgaccgtgac-gacgcg	Protospacer
 *.********* .*************** **.*.

5. spacer 10.1|3132633|29|NZ_CP009755|CRISPRCasFinder matches to MH536815 (Streptomyces phage Crosby, complete genome) position: , mismatch: 7, identity: 0.759

gtcaccgtgcctcccggtcgacggacgac	CRISPR spacer
gtcaccgtgcctcccggtagaacgggacc	Protospacer
****************** **  *. . *

6. spacer 4.1|1124683|31|NZ_CP009755|CRISPRCasFinder matches to NC_021911 (Rhizobium etli bv. mimosae str. Mim1 plasmid pRetMIM1f, complete sequence) position: , mismatch: 8, identity: 0.742

ccactgactcgcgcagcttcgcatccctggg	CRISPR spacer
cgatcacctcgcgcaacttcgcagccctggc	Protospacer
* *... ********.******* ******

7. spacer 5.1|1347819|35|NZ_CP009755|CRISPRCasFinder matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 11, identity: 0.686

cgaagccggtccgggacctcgaccgtgacagatgt	CRISPR spacer
aagggccggttcggcacctcgaccgtgacggtcag	Protospacer
 ...******.*** **************.* ..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2894580 : 2908347

Mycobacterium_phage(37.5%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_144411373.1\|2894580_2896602_-	RNA-directed DNA polymerase	Q2P9X6	Enterobacteria_phage	4.4e-13	32.7
WP_158407772.1\|2896594_2897845_-	hypothetical protein	NA	NA	NA	NA
WP_058725585.1\|2898017_2899019_-	class 1b ribonucleoside-diphosphate reductase subunit beta	R4TBI6	Mycobacterium_phage	1.1e-153	83.0
WP_066656294.1\|2899113_2901219_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	2.8e-204	50.8
WP_066656296.1\|2901236_2901653_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J6X7	uncultured_Caudovirales_phage	3.0e-17	44.0
WP_058727719.1\|2901765_2901999_-	glutaredoxin-like protein NrdH	V5UN81	Mycobacterium_phage	2.0e-18	59.2
WP_066656297.1\|2902411_2903617_+	MFS transporter	NA	NA	NA	NA
WP_066656298.1\|2903665_2904484_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	2.6e-57	41.5
WP_144411374.1\|2905167_2906658_-	MFS transporter	A0A0M3UL24	Mycobacterium_phage	3.4e-55	33.4
WP_066656302.1\|2906752_2907382_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_144411375.1\|2907378_2908347_-	NAD(P)/FAD-dependent oxidoreductase	A0A1V0SIN1	Klosneuvirus	2.1e-13	25.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP009755

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection