CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP006741	Bifidobacterium longum subsp. longum GT15 chromosome, complete genome	4 crisprs	cas3,DEDDh,WYL,casR	0	1	0	0

Cas Category Instructions

Results visualization

1. NZ_CP006741

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP006741_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP006741_1

245316-245684

Orphan

Consensus_repeat	Method
CGATGACCCGTGGAATCAACCGCA	CRISPRCasFinder

6 spacers

The CRISPR arrays of NZ_CP006741_1

>merge|NZ_CP006741|1|245316-245684|CRISPRCasFinder
CGACGATCCATGGAATCAGACGCAGTCTCAGGCCGCGGTCTCACCGGCGTCGCAACCGGCCGAAGCCGACCCGTGGAACCAGCCATATCAGCAGTCTCCTCACGATGATCCGTGGAATCAACCGCAGGGGAACCATGCTCAGGCGGCTCCGCAGCCAGGAGACGACCCGTGGAATCAGCCTCAGTCCCAGACTCCGGCTTCTTCGGTTCCTCAGACAGTGTCGGGCAATATGTCGGGCGATGACCCGTGGAACCAGCCCCAATCGGTTCCGCAGCCGGCTGCCGGCGATGACCCGTGGAATCAACCGCAGGCAGTTCCACAATCGGCTCCGCAGGCCACCCCGCACGGTGACCCGTGGAATCAACCGCA

>NZ_CP006741|1|1|245316-245684|CRISPRCasFinder
CGACGATCCATGGAATCAGACGCA	GTCTCAGGCCGCGGTCTCACCGGCGTCGCAACCGGCCGA
AGCCGACCCGTGGAACCAGCCATA	TCAGCAGTCTCCTCA
CGATGATCCGTGGAATCAACCGCA	GGGGAACCATGCTCAGGCGGCTCCGCAGCCAGG
AGACGACCCGTGGAATCAGCCTCA	GTCCCAGACTCCGGCTTCTTCGGTTCCTCAGACAGTGTCGGGCAATATGTCGGG
CGATGACCCGTGGAACCAGCCCCA	ATCGGTTCCGCAGCCGGCTGCCGG
CGATGACCCGTGGAATCAACCGCA	GGCAGTTCCACAATCGGCTCCGCAGGCCACCCCGCA
CGGTGACCCGTGGAATCAACCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP006741.1\|WP_007051621.1\|245959_246562_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_CP006741.1\|WP_007054686.1\|246558_247692_-\|class-C-sortase	unknown	unknown	gnl\|CDD\|320676
NZ_CP006741.1\|WP_007051614.1\|251690_252785_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|236329
NZ_CP006741.1\|WP_007051613.1\|252952_253573_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP006741.1\|WP_007051616.1\|250222_250987_+\|aspartate-kinase	unknown	unknown	gnl\|CDD\|235843
NZ_CP006741.1\|WP_007051627.1\|239753_240041_+\|DUF4244-domain-containing-protein	unknown	unknown	gnl\|CDD\|379429
NZ_CP006741.1\|WP_038426251.1\|240473_240851_+\|flp-pilus-assembly-TadE/G-like-family-protein	unknown	unknown	gnl\|CDD\|274799
NZ_CP006741.1\|WP_008783736.1\|238866_239469_+\|Flp-pilus-assembly-protein-TadC	unknown	unknown	unknown
NZ_CP006741.1\|WP_007051630.1\|236189_237140_+\|P-loop-NTPase	unknown	unknown	gnl\|CDD\|274798
NZ_CP006741.1\|WP_162010160.1\|248054_248351_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP006741.1\|WP_007054687.1\|248578_249862_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379306
NZ_CP006741.1\|WP_007051624.1\|240899_242030_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237021
NZ_CP006741.1\|WP_007055558.1\|253907_255374_+\|metallophosphoesterase-family-protein	unknown	unknown	gnl\|CDD\|277329
NZ_CP006741.1\|WP_052122971.1\|237146_238214_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	unknown	unknown	gnl\|CDD\|200328
NZ_CP006741.1\|WP_007051615.1\|251042_251609_+\|ACT-domain-containing-protein	unknown	unknown	gnl\|CDD\|235843
NZ_CP006741.1\|WP_032682807.1\|240046_240424_+\|pilus-assembly-protein	unknown	unknown	gnl\|CDD\|377921
NZ_CP006741.1\|WP_007051609.1\|255865_257782_+\|2-isopropylmalate-synthase	unknown	unknown	gnl\|CDD\|235154
NZ_CP006741.1\|WP_038426252.1\|242227_242827_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP006741.1\|WP_007051631.1\|235241_235967_+\|DedA-family-protein	unknown	unknown	gnl\|CDD\|182775
NZ_CP006741.1\|WP_007054679.1\|238213_238870_+\|Flp-pilus-assembly-protein-TadB	unknown	unknown	gnl\|CDD\|227300

Protein	Function_ID	Function_description	E-value
NZ_CP006741.1\|WP_007051621.1\|245959_246562_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	4.73611e-118
NZ_CP006741.1\|WP_007054686.1\|246558_247692_-\|class-C-sortase	gnl\|CDD\|320676	cd05827, Sortase_C, Sortase domain found in class C sortases. Class C sortases are membrane-bound cysteine transpeptidases broadly distributed in Gram-positive bacteria (mainly present in Firmicutes and Actinobacteria). They function as pilin polymerases responsible for the assembly of pili, which are multi-subunit hair-like fibres that extend from the cell surface to promote microbial adhesion and biofilm formation. First, one or more class C sortases form the long thin shaft of the pilus through linking together pilin subunits via isopeptide bonds. The base of the pilus is then anchored to the cell wall by a housekeeping sortase or, in some cases, the class C sortase itself. Depending upon the organism both the number and type of sortase enzymes involved varies, and in some cases, accessory factors appear to be needed. In three-component spaA pilus from Corynebacterium diphtheriae, the prototypical class C sortase (named Cd-SrtA) catalyzes polymerization of the SpaA-type pilus, consisting of the shaft pilin SpaA, tip pilin SpaC and minor pilin SpaB. The pilus shaft is then attached to the cell wall by a housekeeping class E sortase, Cd-SrtF. In the absence of Cd-SrtF, Cd-SrtA attaches the pilus to the cell wall, albeit at a reduced rate. Cd-SrtA can recognize two distinct sorting signals (LPLTG in SpaA and SpaC, and LAFTG in SpaB) and it can employ lysine residues that originate from different proteins (either Lys190 within the pilin motif of SpaA or Lys139 in SpaB). However, Cd-SrtA cannot be able to polymerize the major pilin subunit SpaH, even though it contains LPLTG motif. In two-component pili of prototypical Bacillus cereus, the class C sortase (named Bc-SrtD) cleaves related sorting signals within a major pilin protein BcpA (LPVTG) and a minor tip pilin BcpB (IPNTG), and catalyzes a transpeptidation that joins the threonine residues in each signal to the side-chain of Lys162 in BcpA (located within a pilin motif). Unlike the SpaA pilus in C. diphtheriae, in B. cereus Bc-SrtD is unable to covalently attach the pilus to the cell wall without the help of the housekeeping sortase.	1.19515e-84
NZ_CP006741.1\|WP_007051614.1\|251690_252785_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|236329	PRK08664, PRK08664, aspartate-semialdehyde dehydrogenase; Reviewed.	0
NZ_CP006741.1\|WP_007051616.1\|250222_250987_+\|aspartate-kinase	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	3.11844e-146
NZ_CP006741.1\|WP_007051627.1\|239753_240041_+\|DUF4244-domain-containing-protein	gnl\|CDD\|379429	pfam14029, DUF4244, Protein of unknown function (DUF4244). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.	3.09108e-14
NZ_CP006741.1\|WP_038426251.1\|240473_240851_+\|flp-pilus-assembly-TadE/G-like-family-protein	gnl\|CDD\|274799	TIGR03816, tadE_like_DECH, helicase/secretion neighborhood TadE-like protein. Members of this small, highly hydrophobic protein family occur in a pilus/secretion-like region that usually is next to an uncharacterized DEAH-box helicase, in Actinobacteria. Members show sequence similarity to the TadE-like family described by pfam07811. The function is unknown. [Unknown function, General].	4.39654e-24
NZ_CP006741.1\|WP_007051630.1\|236189_237140_+\|P-loop-NTPase	gnl\|CDD\|274798	TIGR03815, CpaE_hom_Actino, helicase/secretion neighborhood CpaE-like protein. Members of this protein family belong to the MinD/ParA family of P-loop NTPases, and in particular show homology to the CpaE family of pilus assembly proteins (see ). Nearly all members are found, not only in a gene context consistent with pilus biogenesis or a pilus-like secretion apparatus, but also near a DEAD/DEAH-box helicase, suggesting an involvement in DNA transfer activity. The model describes a clade restricted to the Actinobacteria.	9.19902e-11
NZ_CP006741.1\|WP_007054687.1\|248578_249862_+\|ATP-binding-protein	gnl\|CDD\|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	1.02552e-37
NZ_CP006741.1\|WP_007051624.1\|240899_242030_+\|hypothetical-protein	gnl\|CDD\|237021	PRK11914, PRK11914, diacylglycerol kinase; Reviewed.	4.36051e-31
NZ_CP006741.1\|WP_007055558.1\|253907_255374_+\|metallophosphoesterase-family-protein	gnl\|CDD\|277329	cd07383, MPP_Dcr2, Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain. DCR2 phosphatase (Dosage-dependent Cell Cycle Regulator 2) functions together with DCR1 (Gid8) in a common pathway to accelerate initiation of DNA replication in Saccharomyces cerevisiae. Genetic analysis suggests that DCR1 functions upstream of DCR2. DCR2 interacts with and dephosphorylates Sic1, an inhibitor of mitotic cyclin/cyclin-dependent kinase complexes, which may serve to trigger the initiation of cell division. DCR2 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	9.95244e-33
NZ_CP006741.1\|WP_052122971.1\|237146_238214_+\|Flp-pilus-assembly-complex-ATPase-component-TadA	gnl\|CDD\|200328	TIGR03819, heli_sec_ATPase, helicase/secretion neighborhood ATPase. Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.	2.32575e-90
NZ_CP006741.1\|WP_007051615.1\|251042_251609_+\|ACT-domain-containing-protein	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	1.06061e-66
NZ_CP006741.1\|WP_032682807.1\|240046_240424_+\|pilus-assembly-protein	gnl\|CDD\|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	6.63015e-07
NZ_CP006741.1\|WP_007051609.1\|255865_257782_+\|2-isopropylmalate-synthase	gnl\|CDD\|235154	PRK03739, PRK03739, 2-isopropylmalate synthase; Validated.	0
NZ_CP006741.1\|WP_038426252.1\|242227_242827_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.11121e-15
NZ_CP006741.1\|WP_007051631.1\|235241_235967_+\|DedA-family-protein	gnl\|CDD\|182775	PRK10847, PRK10847, DedA family protein.	1.7339e-45
NZ_CP006741.1\|WP_007054679.1\|238213_238870_+\|Flp-pilus-assembly-protein-TadB	gnl\|CDD\|227300	COG4965, TadB, Flp pilus assembly protein TadB [Intracellular trafficking and secretion].	0.00112832

>NZ_CP006741.1|WP_038426252.1|242227_242827_-|TetR/AcrR-family-transcriptional-regulator
MSDTLDEERPTRGDARRDAIVQAARKVCLEKGFSKITVSDIASEVGMTRSLFYHYFEDKEAVADAVLDNVIDEILTTLKQWNQARETGNVNKALDDIVHVLRSLIADESPFSNRMIQDGNAELYIKFIDRAADRIADYIAQTTVRDFEQMHGLPITNVHETFFTLIVGLISLIRSHPNISDRTIKEVMAQTLHIESYVV
>NZ_CP006741.1|WP_007051624.1|240899_242030_+|hypothetical-protein
MSESERNERRRVVAMVGNPTSDKGRGAKVDAQVLGLLEEAGRAHNFDVIDITGTSFDDSLNQARERAHEYDYLVVVGGDGMIALGANAVGCSGKPLGIVATGSGNDFARGLKLPVNRIETAVEGIVGAIVRGSHIDVDMGRVTSLDGGYAVDPSTGEEYEYQESKSAEHPIDRYYAGMLSCGLDASINDRANHSHLPTGTMRYFAAVLVELTHMKRYGYHIKATLADGTTDERDIITPLLTIANSRHIGGGIEVSPYSCFSDGLLDLVWMDHVPNFGECAVAISNAYNGKLLASKVFGWKRIREIEVTRATEGDEPPVLMADGEYIGHLPFRVVAEDCALRVLVPPAVAAREVDSRQEVLNAIARDGRDPVTGQFA
>NZ_CP006741.1|WP_038426251.1|240473_240851_+|flp-pilus-assembly-TadE/G-like-family-protein
MRYEEGSGTMAGAMLVMVVGIALAVAASVGNLMICQNRARSLADLIAFDTAYALWHADIGDPCALAANMAEANGVVLGSCSVRDEDVLVTIKVETMVLVASSVERMARAGPVSCTEGDNYHNNGP
>NZ_CP006741.1|WP_032682807.1|240046_240424_+|pilus-assembly-protein
MKTMTCRWRLARLPPDLCTGSATAEFAIVLPSIIAIAGLILAIGRVVIVSMDCQSAAAAAAREFVVTGDESSARSIAADVAGGKPHVSIAHDGQSTSVTVECSVLPGPLDVTPTRVTGNATAISQ
>NZ_CP006741.1|WP_007051627.1|239753_240041_+|DUF4244-domain-containing-protein
MNTPIPVIVDGQAGIFAHSKARVATLNAKAKERLCLMDARIRTLMAEPEEGAATAEYAVVLVAATGFAAVLVAILKSDAIKTLLTNIIKQALKVG
>NZ_CP006741.1|WP_008783736.1|238866_239469_+|Flp-pilus-assembly-protein-TadC
MSTVWVHAAAGCAAIASWLYKAPSCHDSRLPGEEPAVAHDCGSSWTILILRMSQVSLRQGSSIPRALDMVGKAVGGDCGARMSEVGRSLTRGVPWADAWHAAMAVQHEGAPADSSSGKRTSRTQRDLGLLQSALESSWTHGDMPGVRLESAIEQLDRDERAAIERNAAKLSVKLLMPTGLCFLPAFVLVGVIPAIASFMM
>NZ_CP006741.1|WP_007054679.1|238213_238870_+|Flp-pilus-assembly-protein-TadB
MMWCAVLVALAVLIWPGNKSGRLYRLAYRGRAVDSAAINEPRYAGSPRVGVAQVITSAIARLRGGGTLVEAFEEQSSRRFATQRITVERLITVFEQRRLPDESPAQVLEAARGVTAAAVLSDELGCQAVPCLEAVLTAYRQMRLMQNLRSQACAVPKATVGLLSALPAVTVALGELLGARPLAFLLGSPRGVVCLVLGGCCYAAGLAWMRALLKGSGL
>NZ_CP006741.1|WP_052122971.1|237146_238214_+|Flp-pilus-assembly-complex-ATPase-component-TadA
MAAVITRADKPGAVPRTVFFGLLNDVASDPQVTDLAVTCDGRVWADRGNGMRETVLRVPFRSPQVVREYAVQLCAQLGRRLDDACPIADAASPDGIRVHAVIAPLVPQGAAISIRFPDRTMASLRHLSQLGVFPAAWLPMFVGLVRRHATVLITGGTGVGKTTLLKALLAQCDVNERIVTVEEVRELGELGRGDHVSLVTREANVEGVGAISLTDLVKATLRMRPDRVVLGECRGAEIVDLLRAFNSGHHGGMTTVHADGVNRVPSRLISLGLLAGVSPQALAMLAAGAFDAVVHLERVNGQRRITQIGELRVAHGELAGTPLAVWNGCHPPRYAAEWGHFIERWGIVPGPSGGG
>NZ_CP006741.1|WP_007051630.1|236189_237140_+|P-loop-NTPase
MNSNTTPRVARRITSPAVAPPGIPLPTDDAPIPAHRYYTPPPRPLASCERQRSGEAPALALTTDTSFHNIVTMTSGHGGVGLSVMASMLAWTLARREHSCALIDADFVAGCLDLLLGVEREPGLRFSQVDAPLGRIEGDAMNHELMMWEGVRVLPYDPWSARQPDWWEVQAAIRALAETNDVVIVDAGQGGLIETVPDLRSGMQVIAAELSVMGLARAKSHRSRLDSWGCEAPHIVGVEPRGAPRGRGHVGIGEAQDYLTATVLGPVKPSVNLCGDVLEGLGIRSVTKGSRKAVSLLADLVEQAIRPVSGASCKDR
>NZ_CP006741.1|WP_007051631.1|235241_235967_+|DedA-family-protein
MGFVNFIIELLKDPRAAIAGWIAMGVAPTLGFIFLIVFIETGVVFFPFLPGDSLLFAAGVFAAPDAATGKAALPLFWLLPVVWCAPIIGDQCNYFIGHFFGRRIIQSGKVKALTPERLAKTEGMIEKWGPLAVFLGRFFPFIRTFMPFISGISGMRWSRFTPFSVLGGLCWSTLFTLLGYFFGNIPAVQDHFELVIVLILLVSLAPTIIGLLKAKFGKKKPAKVTDAQLDVMEDGIKNLDK
>NZ_CP006741.1|WP_007051621.1|245959_246562_+|recombination-protein-RecR
MALAYDGAIQRLIDAFGRLPGIGPKGAQRIAFYMLSAPEDEARDLAEAIEEVKAKIRFCDICGNVCESSPCPVCADPRRDRSVICVVEEPKDVMSIERTREYHGLYHVLGGAINPMANVGPADLRIPGLLKRLEGDEVKEVIMALDPNIEGEATTSYLTQLLRPVGVKVTRLASGLPVGSDLEYADEITLGRALAGRREA
>NZ_CP006741.1|WP_007054686.1|246558_247692_-|class-C-sortase
MALLHRRSTSKRASQKMWENNAAMPDDASANDNVSSARPEPAAFVPTPFDEVIDISDLVAERRRLQRNLWAMRIITIVLLIAAIAVACFPLALQFESDRNLAATTATTAKEVAGWPYPQAEDKLTAARAYNKKLAESGQPILGEAVDPFAAAQGGSQASGEDSASKKDKEYQSLLNTGNGVMGTIKVPKQSINLPFYHGTSEEALASGAGHLYGTSLPVGGKSTHSVITGHRGLVEALMFTRLDEVKEGDFFYIEVMGETLGYKVDRISVILPDDTSKLKIVPGEDRVTLMTCTPYGVNTHRLLISGHRVAIPMPAPEPNDVLDARNIALGVGLGILAAGLFIIWLARRHKAARIIRHGAFWPWMRRKGESANDTLA
>NZ_CP006741.1|WP_162010160.1|248054_248351_+|hypothetical-protein
MHKEGICYLDKRGAIAVFVDVGSSSSRWFRRREGRSRVFCFPTKEMNHEERLSKSSFAGLPNVKGAVAEDARITDSPLRSELASVIREKMALSGHLSF
>NZ_CP006741.1|WP_007054687.1|248578_249862_+|ATP-binding-protein
MAVESSEIQRGEYLPRVADGLLTQALQSSGAVQIKGPKWCGKTATAERQSASQVFMQDPDRSATLLALADTKPSLILRGEEPRLIDEWQMAPQLWDAVRFAIDRGRGRGRFILTGSATPQQEPAHSGVGRIARLTMRTMSLFESQESTGVVSLGELFDGNHDVSGFSDFDIENTAFALCRGGWPEAVVESRVNVALRMAADYVEELLDSDINRMDGIKRNKTWMRLIMRSYARNISSQASQSTIAADMQGEPPSEGTLSDYLDALSRACVTEDLPAWNPRLRSKTAVRTSPTRHFSDPSIACAVLHATPEKLLNDFETFGLLFESMCIRDLRVYADALGGDVFHYRDKTGLESDAVIGLHDGRWALIEVKLGEKQVDIAAAHLKKLADRIDQDHEGRPSFLMVLTATAAAYRRDDGVLVVPLATLAP
>NZ_CP006741.1|WP_007051616.1|250222_250987_+|aspartate-kinase
MALIVQKYGGSSVADTESIKRVAKRVVETEKKGNKVAVVVSAMGDTTDDLIDQALSIDSNPPEREMDMLMTAGERISMSLLAMAIHAEGSRAHSFTGQQAGFFTDARYGAAHIKAVRPDRVKNALSLGDIAIVAGFQGINAKGDATTLGRGGSDTSAVALAVALGADICEIYTDVDGIFTADPRIVPSARRIPSIDYESILEMASCGSKVLALRCVEYAQRFNMPLHVRSSFSRRPGTLVVPDGIDPRTLPNLD
>NZ_CP006741.1|WP_007051615.1|251042_251609_+|ACT-domain-containing-protein
MTEEEAKSMGDLFPDLGPEAPVISGIAHDRSEALATVRGVPNEPGMAAKVFTELATAGVNVDMIVQAGASVGTADISFTVPESAVKQVQNTLLDKQEVLGYHSFDVDTNVGKVAVVGVGMKTHAGLAAKFFQALSDEGINVLMISTSEIRIAALVPLDQLNDAVKALHTAYGLDADQIEAVVYGGTGR
>NZ_CP006741.1|WP_007051614.1|251690_252785_-|aspartate-semialdehyde-dehydrogenase
MSEKLKVGILGATGMVGQRFITLLENHPWFEVVTLAASAHSAGKTYAEAVGDRWKMETPMPEYVKNMVVVDGDDAESVASGVDFMFSAVNMPKDQIRAIEERYAKTETPVVSNNSAHRWTPDVPMVVPEINPEHFEVIEHQRKRLGTTRGFIAVKPNCSIQAYTPALAAWKEFEPREVVVSTYQAISGAGKTFKDWPEMVGNIIPFISGEEAKSEKEPLKVFGHVDAAKGEIVPFDGDLKITSQCIRVPVLNGHTATVFLNFGKKATKEELIDRLVNYTSKASELELPHAPKHFIQYLTEDDRPQVKLDVDYEGGMGVSIGRLREDSIFDWKFVGLAHNTLRGAAGGALECAEMLKALGYITKK
>NZ_CP006741.1|WP_007051613.1|252952_253573_+|hypothetical-protein
MSIASVEAQKQLDRIVALGYPDVADISAAAFRSLARPLIGALEHSDLGSNILLVPTRELVSPESLIARTSINRMAGFTTMPPRDIASFLPQDGFMPPEGPFYLVVNPHTGTCYVNREPDVARKLIDSDERLPLTLEEGLAIATQHPEWLLEKNGFNLLGSRSADGRVPSIWMSQNAPRLGAVWPNSRHTWLGNAYCTARRGVSLFR
>NZ_CP006741.1|WP_007055558.1|253907_255374_+|metallophosphoesterase-family-protein
MTNLRFREDGSFRVLQMADIQDGPNVLPDTIRLIREAIRKADPDLVVFTGDQIRGYDPAYIDTFLRRRGEEPGARVRAVTEVEAKLRGIKRRARNRVNNRLLAMKSDGSNPDVQQTASTASTTSTLVYSTTSDPQDVPTTLDELMDETRDKVRRTFAGFLGPVIEAEVPFAATYGNHDFQCGILADEQDGIYREFPGCLNPVDSLEPGTFALPIEASDGSGRVAMSVMMVNSGDYAGKPEENDAQYPAYVVNPRGLDLADSDGYGTPSPEAIDWLGAVQSELGERNGDGKPVPAIAFQHIPPQEFYDCLKEVPAWTPNAVEGARTHAGHCYVLNHEICRPGSRLGEAIGCADENVGEVDALREAGGYFALFCGHDHKNAFVGHAHGIDLGYAPTCGFECYGPKSRYRGIRLFEFHESNPAGYVTRMLTWGDLVGRYSSNEVRVWFEDHCVTGAISMRNELRRPQVFAVLSGAMSLGFMAVIRSLVKKR
>NZ_CP006741.1|WP_007051609.1|255865_257782_+|2-isopropylmalate-synthase
MGQDQSSVFDLAAVAAASNGGNNDPLLPPARFIGDPQKPSRMPYNKYAAYDKQIPFDYPERTWPGKRLQRAPRWCSVDLRDGNQALVNPMDSERKLRFWNLLVSMGFKEIEVGFPSASETDFDFIRMLIERELIPDDVTIVVLTQCREHLIRRTYEALKGAKRAIVHFYNSVSVLQREVVFRKNKEEIKKLATDAAELCKDLENEAKGIDLYYEYSPESFTGTEPEYAVEVCNAVIGVIKPTPEHPMIINLPATVEMTTPNVFADEVEYVSTHLDDRDSVVLSLHPHNDEGMGVAATELAVLAGADRVEGCLLGNGERTGNVDLVTLGLNWLTQGIDPQLDLSNVPEIRKTVEYCNQIKISERHPYAGNFVFTAFSGSHQDAIKKGLEARQVAAERAGADLDSFVWLVPYLPIDPKDIGRTYEAIIRVNSQSGKGGMAYLLKTNHNLDLPKRLQIEFDKIVQNYADTTKKEVKDEDIWRLFKDEYLPVEQSGMTAAGVVVGDTHDASLVPWGRLKLLKVAVSSGEDGSDTVLKARLLDRGVNVGVDAPVEREVSGIGNGPIAAFLNAISNFGVDASIMDYVEHTMSVGTDAMAASYVECQVGEADDAQIVWGVGIDSSITTSALKSIISAINRFQRKR

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Crispr_ID: NZ_CP006741_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP006741_2

1138983-1139066

Orphan

Consensus_repeat	Method
ATTTCGCGGAAACCGTACGATGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP006741_2

>merge|NZ_CP006741|2|1138983-1139066|CRISPRCasFinder
ATTTCGCGGAAACCGTACGATGAGAACGGGTAAGCGTACGTTCTTCACAAAGTTAGGGATTATTTCGCGGAAACCGTACGTTGA

>NZ_CP006741|2|2|1138983-1139066|CRISPRCasFinder
ATTTCGCGGAAACCGTACGATGA	GAACGGGTAAGCGTACGTTCTTCACAAAGTTAGGGATT
ATTTCGCGGAAACCGTACGTTGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP006741.1\|WP_007057286.1\|1127632_1127971_+\|histidine-triad-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|238607
NZ_CP006741.1\|WP_007055521.1\|1144055_1145936_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP006741.1\|WP_010080601.1\|1147424_1148483_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP006741.1\|WP_007052167.1\|1143648_1143909_-\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|178943
NZ_CP006741.1\|WP_007052156.1\|1129154_1129703_+\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|234575
NZ_CP006741.1\|WP_007052153.1\|1126786_1127584_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|367950
NZ_CP006741.1\|WP_007057281.1\|1134783_1135947_+\|NAD(P)-transhydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|240629
NZ_CP006741.1\|WP_007052155.1\|1127989_1129165_+\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|376820
NZ_CP006741.1\|WP_015713550.1\|1145935_1147345_+\|radical-SAM-family-heme-chaperone-HemW	unknown	unknown	gnl\|CDD\|180172
NZ_CP006741.1\|WP_007052163.1\|1139293_1139914_+\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534
NZ_CP006741.1\|WP_038426384.1\|1137827_1138865_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223999
NZ_CP006741.1\|WP_007053366.1\|1135962_1136268_+\|NAD(P)-transhydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|378941
NZ_CP006741.1\|WP_007052173.1\|1150219_1151584_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240548
NZ_CP006741.1\|WP_162473271.1\|1148711_1149842_+\|glycerate-kinase	unknown	unknown	gnl\|CDD\|376844
NZ_CP006741.1\|WP_007052157.1\|1129778_1131212_+\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP006741.1\|WP_014485699.1\|1142608_1143397_+\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NZ_CP006741.1\|WP_038426385.1\|1141461_1142361_+\|nucleotide-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|237065
NZ_CP006741.1\|WP_007053365.1\|1136267_1137692_+\|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta	unknown	unknown	gnl\|CDD\|376743
NZ_CP006741.1\|WP_007052158.1\|1131213_1132278_+\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NZ_CP006741.1\|WP_007052164.1\|1140137_1141265_+\|branched-chain-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|237363

Protein	Function_ID	Function_description	E-value
NZ_CP006741.1\|WP_007057286.1\|1127632_1127971_+\|histidine-triad-nucleotide-binding-protein	gnl\|CDD\|238607	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.	1.22852e-51
NZ_CP006741.1\|WP_007055521.1\|1144055_1145936_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP006741.1\|WP_010080601.1\|1147424_1148483_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.44675e-71
NZ_CP006741.1\|WP_007052167.1\|1143648_1143909_-\|30S-ribosomal-protein-S20	gnl\|CDD\|178943	PRK00239, rpsT, 30S ribosomal protein S20; Reviewed.	4.15757e-23
NZ_CP006741.1\|WP_007052156.1\|1129154_1129703_+\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	5.2441e-69
NZ_CP006741.1\|WP_007052153.1\|1126786_1127584_+\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|367950	pfam04452, Methyltrans_RNA, RNA methyltransferase. RNA methyltransferases modify nucleotides during ribosomal RNA maturation in a site-specific manner. The Escherichia coli member is specific for U1498 methylation.	2.84763e-57
NZ_CP006741.1\|WP_007057281.1\|1134783_1135947_+\|NAD(P)-transhydrogenase-subunit-alpha	gnl\|CDD\|240629	cd05304, Rubrum_tdh, Rubrum transdehydrogenase NAD-binding and catalytic domains. Transhydrogenases found in bacterial and inner mitochondrial membranes link NAD(P)(H)-dependent redox reactions to proton translocation. The energy of the proton electrochemical gradient (delta-p), generated by the respiratory electron transport chain, is consumed by transhydrogenase in NAD(P)+ reduction. Transhydrogenase is likely involved in the regulation of the citric acid cycle. Rubrum transhydrogenase has 3 components, dI, dII, and dIII. dII spans the membrane while dI and dIII protrude on the cytoplasmic/matrix side. DI contains 2 domains in Rossmann-like folds, linked by a long alpha helix, and contains a NAD binding site. Two dI polypeptides (represented in this sub-family) spontaneously form a heterotrimer with dIII in the absence of dII. In the heterotrimer, both dI chains may bind NAD, but only one is well-ordered. dIII also binds a well-ordered NADP, but in a different orientation than a classical Rossmann domain.	2.15048e-156
NZ_CP006741.1\|WP_007052155.1\|1127989_1129165_+\|PhoH-family-protein	gnl\|CDD\|376820	pfam02562, PhoH, PhoH-like protein. PhoH is a cytoplasmic protein and predicted ATPase that is induced by phosphate starvation.	4.24639e-128
NZ_CP006741.1\|WP_015713550.1\|1145935_1147345_+\|radical-SAM-family-heme-chaperone-HemW	gnl\|CDD\|180172	PRK05628, PRK05628, coproporphyrinogen III oxidase; Validated.	5.42796e-147
NZ_CP006741.1\|WP_007052163.1\|1139293_1139914_+\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	1.13839e-60
NZ_CP006741.1\|WP_038426384.1\|1137827_1138865_-\|alpha/beta-hydrolase	gnl\|CDD\|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	1.39998e-16
NZ_CP006741.1\|WP_007053366.1\|1135962_1136268_+\|NAD(P)-transhydrogenase-subunit-alpha	gnl\|CDD\|378941	pfam12769, PNTB_4TM, 4TM region of pyridine nucleotide transhydrogenase, mitoch. PNTB_4TM is the region upstream of family PNTB, pfam02233, that carries four of this transporters transmembrane regions. PNTB is the beta-subunit of pyridine nucleotide transhydrogenase. This family forms part of the Proton-translocating Transhydrogenase (PTH) Family.	6.23278e-31
NZ_CP006741.1\|WP_007052173.1\|1150219_1151584_-\|MATE-family-efflux-transporter	gnl\|CDD\|240548	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.	7.48533e-104
NZ_CP006741.1\|WP_162473271.1\|1148711_1149842_+\|glycerate-kinase	gnl\|CDD\|376844	pfam02595, Gly_kinase, Glycerate kinase family. This is family of Glycerate kinases.	0
NZ_CP006741.1\|WP_007052157.1\|1129778_1131212_+\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	1.59713e-77
NZ_CP006741.1\|WP_014485699.1\|1142608_1143397_+\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	5.86956e-41
NZ_CP006741.1\|WP_038426385.1\|1141461_1142361_+\|nucleotide-pyrophosphohydrolase	gnl\|CDD\|237065	PRK12334, PRK12334, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	5.43225e-57
NZ_CP006741.1\|WP_007053365.1\|1136267_1137692_+\|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta	gnl\|CDD\|376743	pfam02233, PNTB, NAD(P) transhydrogenase beta subunit. This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes. The domain is often found in conjunction with pfam01262. Pyridine nucleotide transhydrogenase catalyzes the reduction of NAD+ to NADPH. A complete loss of activity occurs upon mutation of Gly314 in E. coli.	0
NZ_CP006741.1\|WP_007052158.1\|1131213_1132278_+\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	1.14477e-133
NZ_CP006741.1\|WP_007052164.1\|1140137_1141265_+\|branched-chain-amino-acid-aminotransferase	gnl\|CDD\|237363	PRK13357, PRK13357, branched-chain amino acid aminotransferase; Provisional.	0

>NZ_CP006741.1|WP_038426384.1|1137827_1138865_-|alpha/beta-hydrolase
MTRSDDVINEDGHDVIATHTRVVRGMAAALAAIAATGAGVTAAAANVMFTFALDTKAKRSTFNMPHEETPKGIEFDMSEQLEAARWFEEAKQSVTLRSHDGLKLHGWLLDPDCSDPQPHLYAICCHGYAGEPAEMAKWAHRYAQLGFTVLLPAQRAHELSEGRYVGMGLLESDDLLGWVSLITAADPDARILLHGNSMGAATVMMAAGDARLPRNVIAAISDCGYSSVVSQFTDNAEEMFRLPHSLAALLVKVASHVSKRKAGYRFEDASCVKALRHSTIPMMFIHGGADTFVNPKYLDINYNACASIDREKLLIPGADHTMSASTDPDRYWRRVNSFVKRVFGL
>NZ_CP006741.1|WP_007053365.1|1136267_1137692_+|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta
MTSATVGAIDIVAWFVYLFSAVLFVVGLHFMNSPKTARKGNQISAFGMVVAVLMAFIVLFAKGFVNIVAVVVLVVGILIGAVAGVVSAKKVKMTDMPQLVSVFNTVGGGAAALVALNDILTKEGTPDIVVLITAGLGILIGSVTFTGSLIAAGKLQGIKWVKKLNLPGKGVWNILFAVLSVASLVMLCVQPEQRLLWSILTTVFALCYGLVFVIPIGGADMPVVISVLNACTGTAVAMSGLAIDNVALIVAGALVGSAGVTLSILMAQAMNRPLLSVLAGGFGGGADAAAAGDGPEGTMKETTPDDLAVQLVYAQKVIFVPGFGLAQAQAQRELADLGELLKGHGVEVSYAIHPVAGRMPGHMNVLLAEANVPYEELVDLDEINPQFPQANVALVVGANDVTNPAARRPGTPVSGMPILDVDKSQNVVVMKRGRGMGYAGIQNELYFEDNTQMLFGDAKKSLQSVIAAVKELLA
>NZ_CP006741.1|WP_007053366.1|1135962_1136268_+|NAD(P)-transhydrogenase-subunit-alpha
MPTLVVSITLFVLALLIGIEVIGKVPATLHTPLMSGANSIHGIVIVGVVIVAAEANSPLAYVFIFLAAVLGTMNVVGGYVVTDRMLEMFKSSKNEKKGESK
>NZ_CP006741.1|WP_007057281.1|1134783_1135947_+|NAD(P)-transhydrogenase-subunit-alpha
MAQNPEATVVFGVLNETSETESRVALTPDIVTRLKRSGVSSIIEAGAGIAAEYTDEDYEKAGAKVTSRDEVLAEADALGFVDRPSAETVAKLKAGQWVIGMLGSFTDADYVAALEKAGLVGIAIEKLPRKLSSAQSMDEMTSQNSVMGYKAAITAADAYGSFLPMMTTAAGTIRPAKALVLGAGIAGLQAIGTLKRLGAVVTAYDVRPASQGEVESLGAKFLDLGLDFSKGQGEGGYARALSAEEQAQQQAAVDEKAAGFDIIITTAKVPGRKPPVLLTAAGVKGLKRGAVIVDCAASDLGGNVEGSAVGEQVTEGGVKLIGAPYLASGVATTASNLLSRNVADILVHFVRDGKLGQDLTEELDDALVVAGRAAAPAAAADAEKSEK
>NZ_CP006741.1|WP_007052158.1|1131213_1132278_+|GTPase-Era
MTDQNNSTNDVDDIDVTDASDVAGVAEVDATGETENVTKQDVPYRSGFVAVVGRPNVGKSTLINALIGKQIAIASSRPETTRKAIRGILTADHAQLVLVDTPGIHRPRTLLGQRLNDVVDESLADVDVVAFLLPADQEIGPGDKRILSRLRTDFATKREDGTFKWRIPLIAIVTKIDELGRQQLINKLIEINDFADFSDIVPVSALKHDNLAEVKNVLIEHTPEGPQMYPDDQISEERPEDTIAELVRGAFLETLDDELPHSLAVVVDSIDYPEDNETGQGYDGKAQVNVSIYVERDSQKPIIIGKGASNLTYVKKKLRTPVNRIVGQKAKLDLHVKVAKGWQSDPKQLERLGF
>NZ_CP006741.1|WP_007052157.1|1129778_1131212_+|HlyC/CorC-family-transporter
MEYSSTTPIAITVILVLVAALFVWLSLTMAAAEGAVARVTRASLNNLILEVQTDSEASQFLKMKKIDKIHRVQRLIADRYATAGSCAFFRIACNVLDGVLVSSIASLWGAELWIELLSGFLFAIIVAVVSVLVRPRTAGMAKPVGIMISNSRIVSLATKLTPFARIGGDKSGSKGPGRRSKDSDLSDDEELEKIQLEQGKAAIDRLVESNDFDPEVSEMLRNVLTLSDTLTREIMVPRTDMICMERDSTLSSALKLFSRSGFSRVPVIGEDVDDLIGVAYLKDAVRATAFNPAAMERAVESIVRQPLLVPESKPVDDLFHEMQRSRQHVAVVVDEYGGIAGMVTIEDAIEQIVGELEDEHDRTQRTEPEKIGDNKWKMPARTPIADLEEIFEIDIDEDDVDTVYGLLTKILGRVPIVGASAVTRGLRLTAVDSAGRRKKVSTIVVEPAHVEGGEENNKTHEETDGEPVEGDDTASKE
>NZ_CP006741.1|WP_007052156.1|1129154_1129703_+|rRNA-maturation-RNase-YbeY
MSVDVTNETQWVIDPKVFSDLGIWVLDQMRVSTQSDLTIMFVDPDPIAELHMRWMNLEGPTDVMSFPMDELRPGDGKTVMEGVLGDIVICPWVAAQQAAAAGHSTMQEMLLLTIHGILHLLGYDHVTPEQERQMFGLQRQLLLTFFALRHDANVQATLPAGTPDALALYDAAHGAGRDLDSK
>NZ_CP006741.1|WP_007052155.1|1127989_1129165_+|PhoH-family-protein
MATTTRTITIPPQLDPVAVLGPVDEVIREVERAFPDLTIIVRGNRVAIVSRSKQTEAQAAQAEDLVNTIIQAAYTAPMDADTVRRMLDQNVLKNHVRLEHPGHGPVRDKLAQSTSNERAHARSAGSHDPTYRKPTVPGVITFAAGVPVRAKTAGQVAYVNAIESHTITFGIGPAGTGKTYLAVAKAVRAFQDKQIRRIILTRPAVEAGESLGFLPGTLNDKVDPYLRPLYDALGDMLGADQLKRYMDDGSIEVAPLAYMRGRTLNDAFVILDEAQNTTEQQMKMFLTRLGFNTTMVITGDISQVDLTVPRSGLATIERILGGINDIAFVHLKTEDVVRHQLVGQIVAAYDRHSAIAGDHRDIERKGRRNHTDFDARQQADSTNQSETDDER
>NZ_CP006741.1|WP_007057286.1|1127632_1127971_+|histidine-triad-nucleotide-binding-protein
MSESDDCLFCKIIAGQIPSSKVYEDETTYAFNDINPKAKVHVLVVPKKHYANVAELAAGDPTELAHIVSIAQNIADKEFHGAYRLVFNTGLDAGQTVFHVHAHVMTGEKLDE
>NZ_CP006741.1|WP_007052153.1|1126786_1127584_+|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MTDALFLFDPQVDDVPVNSDELHAGWKLTLPAHIKRHAVQAMRLKAGDSLQLSDGNGLRIQAVMADPEAGLAEVVEVGREPEPLTRLALIQALAKTGHDEQAIDMATQIGVDQVVPWQADRSIAKWKVGRTDKKWNSVLDAATEQSRRAFKPQLEACASSKEVVAICRRACVHGDVVIVLHQDATDTWSGVEEKVAQLVERTLQDGRPRTVSVVVGPEGGISEQEVADFVKAGAVSCVLGRNILRAATAGPVALSLLSRVLGRYE
>NZ_CP006741.1|WP_007052163.1|1139293_1139914_+|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MATTIKLEGEARSEFGKGVARRLRVANKIPATIYAGGEEPAFVTLPMRETTLALRHTNALFTIAFDGNTKMAVVKDVQKNPVKRIIEHVDFLEVKAGEKIDVEVPVFVEGTPKGAAVAFVDIQELKVRADVANLPEKIVVSVEGLTDGTKVFAKDVVLPEGVELDVEDPEESVVTVEVPEDASESTAAPEAAAPAADAAAPAADAK
>NZ_CP006741.1|WP_007052164.1|1140137_1141265_+|branched-chain-amino-acid-aminotransferase
MTENTHHDPAALDKLAEPFTVLPNDNPASDEKRQSLIDKPAFGQVFSDNMTHMTWTKGEGWSDRRVEPYAPLKMDPGASVLHYAQECFEGLKAYRHADGSTWLFRPDANAERFQNSAKRLYLPELPIDDFLGSVAALVKRDANWVPSRREYTLYMRPFMFASEPFLGVRAPQEVDYCVIASPSGPYFPGGVKPVSIWVEDKWFRTGPGGTGFAKCGGNYAASLLGEYKGVENGCEQVCFVDAATKTYLEELGGMNMMAVHKDGHVETPSLTGNILPGVTRRSLIQLLQDKGHDVVETMIALDQLLEDIKSGEVTEVFACGTAAIITPIGRFKSEKFDVTVADGGSGKLTCELRDELLGIQLGEVEDPHNWMWKVC
>NZ_CP006741.1|WP_038426385.1|1141461_1142361_+|nucleotide-pyrophosphohydrolase
MSKMSDMTEYHASAYRLPSGFEHCSKLKPVAEAATALDRVKAVVDVLCSPGGCPWDGKQTNKSLLKNLLEETYEYVDAVETHDRDNMREELGDVLLQSVFQARVCESDTEDPFGIDEVADRLVNKLITRHPHVFAADDAGNSSDSSDAFDADSNDGGEAAQPESPEAVLALWEKMKQQEKHRKSVLEGISRAQGALPRAAKVVSRISKSPNADRLFAAFDEPAAADAQRDDVHPQAANQSESSGDNSAEREKADAYADEILAVVRKARVDGIDIESALRNRLRDVEEKVALIESEINND
>NZ_CP006741.1|WP_014485699.1|1142608_1143397_+|trimeric-intracellular-cation-channel-family-protein
MQVALENNIVFVVIEYLAILCWGLSGGLAAIRKGYDIFTIMLCGWLTALGGGLVRDVMLGALPPVGITDKGYVLTTLFSGIIVVVAHPEITKLKWTMTVIDALGLGLFAVSGTAKALAYGSSGMTAVFLGMFTALAGGLIRDIFIGDVPMIIRDKHLYAVPSFIGCILTVLVWRGVSYGWFDMRSEMLLDVLIVIIVVALRLLSVGFNVTLPGAVERHRVYLPSESRYLKRPVIHPHADTGDTPNTKDEEDKPQDGSRPPQG
>NZ_CP006741.1|WP_007052167.1|1143648_1143909_-|30S-ribosomal-protein-S20
MANIKSQKKRVLTNEKAHLRNVAVKSGLKTAIRATREAIAAGDKAAAEAAYKVAAQKLDKAAGAGVIHKNQAANRKSGLAVAINAL
>NZ_CP006741.1|WP_007055521.1|1144055_1145936_+|elongation-factor-4
MVVQHNQPGSTDQSVIRNFCIIAHIDHGKSTVADRILQLSGIVPEREMRDRFLDRMDIEQERGITIKSQAVRVPWTFDGTEYTLGMIDTPGHVDFTYEVSRALAACEGAVLLVDATQGIEAQTLSNLYMAIDHDLAIIPVLNKIDLPSAEPDKHAEEIAGLIGCEPSDVLRVSGKTGEGVADLLDQIVMDVPAPHGDPEAPARALIFDSVYDSYRGIVTYIRMEDGELHDREKVHMMGIGMTHDPIEIGVISPDMTRTKALGAGEVGYIITGAKDVSQSKVGDTLTSAVRPAAEPLPGYRDPKPMVYAGLFPIDNAQFPELRDALDKLKLNDAALIYTPETSVALGFGFRCGFLGLLHMEIVNERLSREFGLDLIQTAPNVTYDVTAEDGSQHHVTNPSEFPDGKIKKIVEPMVAADIITPKEFIGAVMDLCQDHRGIMGTMEYISTDRVEMHYRIPLAEIVFDFFDQLKSRTKGYASLDYHEDGEQSADLVKVDILIQGEKVDAFSAIVHRDKAYSYGVMMTKKLRSLIPRQQFEIPIQAAIGSRIIARENIRALRKDVLAKCYGGDITRKRKLLEKQKAGKKRMKMLGHVEVPQEAFIAALSTGEDSNDRDTKDKIRAAQKTEG
>NZ_CP006741.1|WP_015713550.1|1145935_1147345_+|radical-SAM-family-heme-chaperone-HemW
MFEVYIHVPFCLRRCGYCDFNTYTATDLGAGASRGNYANMVIREMKLTKQWQLDHGIAEPPVSTVFFGGGTPTILAARDLVAMLDAVRKIWGIAPDAEITTEANPDTVNEYYINELAAGGFTRVSFGMQSAVPHVLKTLDRTHTPANVAAGVNAANKAGLRSSVDLIYGAPGESLDDWRTSVTTAIDLGVNHISAYALTVEPTTKMGRQIAAGTLPKPNDDDEAAKYEIADDLFAAAGLEWYEVSNWARPGYESQHNLGYWRNVDWAGLGPGAHSHYNAVTEADHPQSASLTAPAGGGKSEAIASASADGQANAELGMINAHGNNSQEIHAPAGGGCPADAGLGVVSVSHGLRSWDIAHPRLWGTAINENRVPWADSETITPEENLEELIMLGLRLHEGLDLDRINRAINDAGMSSTPQTLRNVSLDQLAPMVSEGLITVSDNHRVVPTRRGRLLNDSVIEQFFDFVGV
>NZ_CP006741.1|WP_010080601.1|1147424_1148483_-|LacI-family-transcriptional-regulator
MDVAKEAQVSIATASRVLNGSTRKVRNQSYVKVMEAATKLNYRPNAYAQAVAKGTAPNIVLLVSDISDPYFASVSQGVVKAAAERGISVTIGVAATPHEELEAVRKSVSTRPRGIIISESEYTDAPERQALQTELTQYEASGGRAVFVLNRNLPFPAVDVANDVGARAIAKLIVDSGYTRPAILKGDDAHRSSKERLAGVMEVLDEAGITVDPKAVANGKFSRTDGYAAVMQMARSGLLKPGEGALYDGKGIDSIIALNDVMAIGAMTALRANGIEPGREIGVTGFGDIPYSADVFPPLTTVHLPLAEMGQAAVDSILSNRDDGEATGGTANRLIYVQSAPDVVLRGSLPRR
>NZ_CP006741.1|WP_162473271.1|1148711_1149842_+|glycerate-kinase
MTRYLCAPDSFKESLTAMEAARAMAQGIENADHDAEVRCLPMADGGEGTARALVDATGGSMRAVPVHDPLGRPVEGHFGLLADGTTAVVETAEASGLALLEAKERNPLIASSYGTGELMLAAVRSGAKRIIVGLGGSATNDAGAGLLQALGVRLLDGDGNDLKHGGAALADLTTIDIGTMDPALKNVAITAACDVTNPLTGPTGASAVFGPQKGASKDDVATLDAALAHFAQVIDSQLGVAVNDVPGAGAAGGIGAALKGFLNAEFRPGIAIVIEQSGLDAAAQWADVVFTGEGSIDFQTKFGKTPAGVAETAKRHGKPVIAVAGHIGTGIDELHEVGIDAVFGIAPGAASLSELLADAAANVTRTTEQIVRTLQL
>NZ_CP006741.1|WP_007052173.1|1150219_1151584_-|MATE-family-efflux-transporter
MDNELFEKAPIPEAYFSLAMPVVLSMLVTLVYNMVDTYFIAHTGNTDMVAGVSLTAPVFTVMIALGDIFGLGGSSVISRLFGQHRFADGKRLSAFCFYAAIATGLLILVLGLAFRDPMLALLGATDDTWQYASDFYTLIIVGSPFIIVSMTPSNLLRTEGHAVQSMIGSVAGTAVNIVLNPLFIHGFGWGAAGSAGATVIANICTDAYFVWFTLRHSSNLSIDPRTVIDRARRRLAVTAREVGSILAIGIPSAITNLTQSVGIVMINLFLLPYGTDAVAAMGIALKVIMIAVLVFVGFAFGAQPLIGYNYGARNMPRLRGILRFSYLFLSLFALVMTVVLSLSDRLLMGFFIEDATIITLGAGMLRVQLLSLVCVAVVMVTTCTFQSAGKAVGAFVLSISRQGVMLAITLFVGSRLAGYQGVIAAQAIADLLTAIVAVILFVVMLPELRSRKAR

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Crispr_ID: NZ_CP006741_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP006741_3

2037586-2037671

Orphan

Consensus_repeat	Method
GGCCCTGAGCGTGCGGGCGCGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP006741_3

>merge|NZ_CP006741|3|2037586-2037671|CRISPRCasFinder
GGCCCTGAGCGTGCGGGCGCGGAATCGCATTTGAAGCGGCATTGCCGCCATTGGCACCGGCGCCGCCCTGAGCGTGCGGGCGCGGA

>NZ_CP006741|3|3|2037586-2037671|CRISPRCasFinder
GGCCCTGAGCGTGCGGGCGCGGA	ATCGCATTTGAAGCGGCATTGCCGCCATTGGCACCGGCGC
CGCCCTGAGCGTGCGGGCGCGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP006741.1\|WP_004268639.1\|2029674_2029764_-\|AURKAIP1/COX24-domain-containing-protein	unknown	unknown	unknown
NZ_CP006741.1\|WP_007056729.1\|2028823_2029522_+\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NZ_CP006741.1\|WP_008783615.1\|2042096_2043665_-\|alpha-N-arabinofuranosidase	unknown	unknown	gnl\|CDD\|226064
NZ_CP006741.1\|WP_007053050.1\|2047955_2048867_+\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|211337
NZ_CP006741.1\|WP_007055304.1\|2044474_2045275_-\|transglutaminase-family-protein	unknown	unknown	gnl\|CDD\|224224
NZ_CP006741.1\|WP_007053049.1\|2048948_2049491_-\|50S-ribosomal-protein-L17	unknown	unknown	gnl\|CDD\|235522
NZ_CP006741.1\|WP_007053048.1\|2049590_2050586_-\|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl\|CDD\|235359
NZ_CP006741.1\|WP_007055359.1\|2030715_2032254_+\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NZ_CP006741.1\|WP_007053815.1\|2033490_2034654_-\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|235113
NZ_CP006741.1\|WP_003829907.1\|2050666_2051065_-\|30S-ribosomal-protein-S11	unknown	unknown	gnl\|CDD\|180007
NZ_CP006741.1\|WP_081966502.1\|2027802_2028693_+\|ribonuclease-HI	unknown	unknown	gnl\|CDD\|260010
NZ_CP006741.1\|WP_038426544.1\|2045481_2047662_-\|circularly-permuted-type-2-ATP-grasp-protein	unknown	unknown	gnl\|CDD\|379601
NZ_CP006741.1\|WP_007052313.1\|2029955_2030588_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP006741.1\|WP_007053811.1\|2040520_2041564_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP006741.1\|WP_007052308.1\|2034655_2035129_-\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787
NZ_CP006741.1\|WP_007055364.1\|2032268_2033393_-\|FAD-synthase	unknown	unknown	gnl\|CDD\|235536
NZ_CP006741.1\|WP_013582922.1\|2039751_2040480_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP006741.1\|WP_007052318.1\|2024996_2025419_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366911
NZ_CP006741.1\|WP_007055323.1\|2025553_2027170_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|235798
NZ_CP006741.1\|WP_007052305.1\|2038476_2039544_-\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061

Protein	Function_ID	Function_description	E-value
NZ_CP006741.1\|WP_007056729.1\|2028823_2029522_+\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	6.02536e-120
NZ_CP006741.1\|WP_008783615.1\|2042096_2043665_-\|alpha-N-arabinofuranosidase	gnl\|CDD\|226064	COG3534, AbfA, Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism].	0
NZ_CP006741.1\|WP_007053050.1\|2047955_2048867_+\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|211337	cd02570, PseudoU_synth_EcTruA, Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1). Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E. coli TruA makes psi38/39 and/or 40 in tRNA. psi38 and psi39 in tRNAs are highly phylogenetically conserved. P. aeruginosa truA is required for induction of type III secretory genes and may act through modifying tRNAs critical for the expression of type III genes or their regulators.	2.46851e-94
NZ_CP006741.1\|WP_007055304.1\|2044474_2045275_-\|transglutaminase-family-protein	gnl\|CDD\|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	3.46877e-29
NZ_CP006741.1\|WP_007053049.1\|2048948_2049491_-\|50S-ribosomal-protein-L17	gnl\|CDD\|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	1.51666e-56
NZ_CP006741.1\|WP_007053048.1\|2049590_2050586_-\|DNA-directed-RNA-polymerase-subunit-alpha	gnl\|CDD\|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	0
NZ_CP006741.1\|WP_007055359.1\|2030715_2032254_+\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NZ_CP006741.1\|WP_007053815.1\|2033490_2034654_-\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|235113	PRK03287, truB, tRNA pseudouridine synthase B; Provisional.	6.2196e-102
NZ_CP006741.1\|WP_003829907.1\|2050666_2051065_-\|30S-ribosomal-protein-S11	gnl\|CDD\|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	1.00735e-79
NZ_CP006741.1\|WP_081966502.1\|2027802_2028693_+\|ribonuclease-HI	gnl\|CDD\|260010	cd09278, RNase_HI_prokaryote_like, RNase HI family found mainly in prokaryotes. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD), residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Prokaryotic RNase H varies greatly in domain structures and substrate specificities. Prokaryotes and some single-cell eukaryotes do not require RNase H for viability.	1.17319e-61
NZ_CP006741.1\|WP_038426544.1\|2045481_2047662_-\|circularly-permuted-type-2-ATP-grasp-protein	gnl\|CDD\|379601	pfam14403, CP_ATPgrasp_2, Circularly permuted ATP-grasp type 2. Circularly permuted ATP-grasp prototyped by Roseiflexus RoseRS_2616 that is associated in gene neighborhoods with a GCS2-like COOH-NH2 ligase, alpha/beta hydrolase fold peptidase, GAT-II -like amidohydrolase, and M20 peptidase. Members of this family are predicted to be involved in the biosynthesis of small peptides.	0
NZ_CP006741.1\|WP_007053811.1\|2040520_2041564_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.46775e-80
NZ_CP006741.1\|WP_007052308.1\|2034655_2035129_-\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	1.2318e-44
NZ_CP006741.1\|WP_007055364.1\|2032268_2033393_-\|FAD-synthase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	5.18065e-81
NZ_CP006741.1\|WP_007052318.1\|2024996_2025419_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|366911	pfam02082, Rrf2, Transcriptional regulator. This family is related to pfam001022 and other transcription regulation families (personal obs: Yeats C).	1.08161e-20
NZ_CP006741.1\|WP_007055323.1\|2025553_2027170_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|235798	PRK06416, PRK06416, dihydrolipoamide dehydrogenase; Reviewed.	1.47009e-81
NZ_CP006741.1\|WP_007052305.1\|2038476_2039544_-\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	8.02178e-151

>NZ_CP006741.1|WP_007052308.1|2034655_2035129_-|30S-ribosome-binding-factor-RbfA
MAGTNPRAARIAALIQRVVASSIERELHDKRLASITVTEVRVTNDLQIAKVYWTQLGHEGHEEGERKRAQQALDQAKGHLRSLVGHKAGLRLTPQLQFVFDEVPGEAHEIEDILAVAKKRDEELARARATAQYAGDADPYKHDDEPSDDFEDDSDEE
>NZ_CP006741.1|WP_007053815.1|2033490_2034654_-|tRNA-pseudouridine(55)-synthase-TruB
MLHTTPSGLLIIDKPQGVTSFDAVAAVRGALHIKKVGHAGTLDPMATGTLVIAFGHATRLLNAIVAHDKTYEATIRLGLRTTTDDAEGEVLVDDEARSRWQTLSAQLTEGGQSGEPTALPTASWQDLLTRTIATNFTGDIEQVPNTFSAIKINGQRAYDLAREGKDVELKPRPVTISEFTVLDIRSGFVAGEQTAEPLREDANTGAIPALDVDVRISCSSGTYIRALARDLGKELGVGGYLTRLRRTRVGRFALPDDASGLIAPEAMLDTRTHTVTAHTDQKTFTNREGQTVTRNKCVLDTPEGLAGDERRNWLLDHALTMEQAARGAMPALDITPEEASELRFGRRIERTISEPTAAIVPQTHDVAAIIERANAHQAKPVTVFPLA
>NZ_CP006741.1|WP_007055364.1|2032268_2033393_-|FAD-synthase
MDITHLTPDAEGSIEWPSFSNDKKAVVTLGAFDGMHLGHQAVIKRVVELAHQHDAFSVVILFDPRPAFVHGWVISHHGEEPAVQNVDAEALTSVDDRLHRMEQFGVDHVLVVHYTLAFAAMSYIFFLGRLTGKLGMRTLVLGQDAAMGKGREGDVKHIANLAAATGVFELDVVDDRGPGEVRIPRDFKPEAPSEWGEPVDPLANATKAERRAWSKKNQAKAMRAWSSTNVRYLLAHGRIQDANAILGAPHSIEGEVVHGEERGRTIGFPTANLGSDIAGYIPVDGVYAGWLVDGENRWPAAISIGTKPTFSEKTGLNERVVEAYCITEEWIDLYDHKVRVEFVGFLRPQVKFDGPDQLVDELKRNVEETKRLTA
>NZ_CP006741.1|WP_007055359.1|2030715_2032254_+|DNA-repair-protein-RadA
MAKSSVQYVCSECGWNGPKWYGRCPECGQWGTVEEFHEARPAAGSRTAAPGRTSRTQSVTVANNARSAARPITEVGTESVERLGTGFSEFDRVLGGGVVPGSVTLIAGEPGIGKSTLLLQTAGNIARVVAGDSTFRGAGQRSAQQSGRAQGNASNTVPMRGNASSTHANTVLYISGEESQAQVRLRASRINAVEPNLLLASTTDLSTVLGLIEQNKPALAIVDSAQTIVSQEVDGISGGSTQVREVASALIDTAKTLDIPVFLVGHVTKDGSIAGPRTLEHLVDVVCQFEGDSETALRMLRAVKNRFGPTDEVGCFDMSGEGIEEVTDPAGLFLSGDGPDAANAAPVEGTCVTFTLDGHRSLPIEVQALVTTSVLPTPRRAVNGVDPSRIAMLVAVLYRHSKLNLLSNDLYISTIAGGQAKEPGSDLAIVAALASAATSKPIARATCAIGEISLTGQVRPVPRMEYRLREAARLGFTTAVIPPLRKPVHVEGLQLVESNTLSDALDALGVRK
>NZ_CP006741.1|WP_007052313.1|2029955_2030588_-|hypothetical-protein
MTNSENSSTTQSHGKLIAVVVAAAVVIILAVLSAFVWPGWAIQKNDGTSTTTQNSQQKTESSEPTKPTIDATALPDDASELLKAMPGSVLNYARTKADASTTWNSASPLEEYTLTYSTGDAAKDVTLVAAQWSSADNAKTQYDALVAAQTGDESASGNVKVSGNVTGAYVVKADASNSKNAVAIWQNDTVVFQATGTKEAVDRFYQKFPM
>NZ_CP006741.1|WP_004268639.1|2029674_2029764_-|AURKAIP1/COX24-domain-containing-protein
MGSVIKKRRKRMSKKKHRKLLRKTRHQRK
>NZ_CP006741.1|WP_007056729.1|2028823_2029522_+|ribose-5-phosphate-isomerase-RpiA
MDKAQQDALKKAAGIEAAKLVENGMIAGLGTGSTVKFLVDELGRRHQEEGLEFTGVTTSRRTQVQAESYGIKIVDIDDVDHIDVTIDGADEVDKNFNGIKGGGAALLWEKIVATNSNQIVWIVDESKVVDTIGKFPLPVEVIPFGAGQVIKKFEARGYKPVLRLDADGKEVRTDENNFVVDLHLERIDHPQELAEDLINTVGVVEHGLFLNMVDKVIVGDPNGPRVMTNANK
>NZ_CP006741.1|WP_081966502.1|2027802_2028693_+|ribonuclease-HI
MTITVSTDGSALGNPNGPMGWAWADHEQNAGGKPGHKHDDHGYDAGGATNGTNQIGELCAVLEALRAHPGPEPLLIESDSQYAINCSTKWVKGWKKNGWKNSQKKPVKNKELIQAIDREISQRPGPVDFRWVKGHAGNEGNELVDELARTYAGDCRSGARDGYLPIEGWQSLLGSEYAHGTDVPPDVQLVLDGKADAASLRKPAAATDQTDAARPETKSSSPLAAQSTQPVQSTQPVPPAKPSGLTVSGTLTFSPAPKTSPYFNGQPMPIKGSIEIEGYVDGDGNLTITNAPFVRH
>NZ_CP006741.1|WP_007055323.1|2025553_2027170_+|FAD-dependent-oxidoreductase
MSISTPNAISTPSTSPTITTDALIIGFGKGGKTLAAKLSAAGRKVVVAEASADMYGGTCINIGCLPSKSLILSAEQARRDGANSTPETREAAFEAAIKEKRRVTSMLRDKNYHKLADQDNITVITGRAHFTGPHSVEIATAEGPVAVTASKIFINTGATPRIPDIPGIHTTPGVYTSTGLMDLDDMPQRLVIIGSGFIGLEFASMFADFGTAVTVLQHNAEFLPREDADVAAAIRAQLEAQGVKFLFNADTKAIAPAADGGVRLSVAVKGMTRGASQACDSTPAGTGNAHTDITGATDTTTTTSPTSNPTDHATMSHVQTKPSDDGEPRFAEPAEARFCLTTDAVLVATGRTPNVEGLHLEAAGVELTERGAVKVDELLRTTAADIWALGDVNGGPQHTYISLDDYRVVWSQLNGSDRPYTVKDRKHVPSSTFLATPYSRVGLNEREAKAAGLDYVVKRLPVAAVPKAQVMRRPDGLMKAIVERNTGRILGAMLLSVESHEVINIVKLAMDLDAPASTLRDMVFTHPTIAEALNDLFA
>NZ_CP006741.1|WP_007052318.1|2024996_2025419_+|Rrf2-family-transcriptional-regulator
MNGDHSLAVHALVYLDHRATHLPSQILAENICTNAARVRKVMRPLASAGLIATKEGAEGGYALARPAAEITLRAVAEATGTTFVKVNWTPGDVHEDCLVSSSMGAVMNDIYAGLNRTCLEQLEHTTIHDITEQIFSERKG
>NZ_CP006741.1|WP_007052305.1|2038476_2039544_-|transcription-termination/antitermination-protein-NusA
MELDLTGIHKLAAEQGIDPETLDDALAEALRLAYLKTPHAAKHARVELDERSGNFTVWAADEIPVEPTEDNPYPAPKLGEEYDDTPRDFGRLAAATARQVITQLFRRAEDEKVFGAFSGQKGKLITGIIQQDASDPSNVHVAMGDVEAILPRREQVPGERYRHGERIRVYVVNVARGIKGPEIVVSRSHPELVRKLFEREVPELVSGAVSIMAIAREAGARTKIAVKANTDGVNPKGALIGPGGARVRAVMENLGPEKIDIVDYSDDPAKFVAAALSPAVATGVQVISEKNKTAIAFIHDDQLSLAIGKEGQNARLAAKLTGWKIGIESAEAHAKKVAAEKAAQAAAEAAAPEAE
>NZ_CP006741.1|WP_013582922.1|2039751_2040480_+|hypothetical-protein
MTPCEKAMTLANYATHPAEGTPLLEQYATGLAAPLAWIDVAGYCSGRFAEGTLRDAQTKQWMAFLADKFGQSAPEVTPARLDGVTSANVDRSVLDAMAVAEDRAGFAIEVLAARGQTAGATLALSDMHKTAGQQLVALANGNFDDSGAQSSSSGQSDPRQKVYAIDQLLANPTTIADKASGQTVPTAAAIEMDCARAQIKAVTESKSSTESDMLLILAALAAKHAYTAFQLGYPATDAELFE
>NZ_CP006741.1|WP_007053811.1|2040520_2041564_-|LacI-family-transcriptional-regulator
MGNRVTIKDVAREANVSIKTVSNVLNDTGSMRPDTRRRVEEVMRKLGYTVNISARAMRSGGTKLIGLNIFDFSQPFVPFFTDKVIEYAKERHYGVVINTYGSDGEGLVASVDESYRLGAEGWILFVMSPLADEGAVLEQPYPIVTTGDHLAYGKSDWITMPNIESISTVVGRFLDEGAQTVALMGVLPELVDEAVLRRQTEGTQALRAQGYVKAFEERGLSVNWRYVIPAESMNQREGMRVTKAMLDKLPCPDVVVCLNDAIALGAIHELQRCGLHVPDDVQVVGFDNVPEAEYSVPALTTIDPHIDDYAKHAVDMLIDRIEGYSGPARTYTTDFTLVERASTRLAH
>NZ_CP006741.1|WP_008783615.1|2042096_2043665_-|alpha-N-arabinofuranosidase
MSEHSHDNKPGELEESRLVVDNDFEVAPVNDRLFGSFVEHLGRCVYDGIYEPGHPEADEDGFRKDVIELVKELGATTIRYPGGNFVSGYRWEDGVGPRDERPRRLDLAWHSTETNQFGLHEMAKWLEKTGGNELMEAVNLGTRGLEEALDLLEYANIPGGTKLSEERRANGADQPFGIKMWCLGNEMDGPWQTGHKSAEDYGTLAASVAAGMRAIDPNVELVVCGSSSHVMDTFGKWEETVLEKTFDNVNFVSCHAYYHPELQPDGTRDMKSFLASGVDMDGFINDVAAAIDATKARLKSKHDVFISFDEWNVWYLNEEPSKNPEGIGNWPVAPRLLEDVYSAADAVVFGDLMITLLKNADRVHAASLAQLVNVIAPIMTEPGGPAWRQTTFYPFSLTAKLAKGGTVLEPKLASGTYETDKYGEVPTINSVAVRGEDGTISVFVVNRSMEAANDFAIKLPEGFALSAVEAQTLHEDDLLAKNTLEDQNRVVLHPNTTITSDADTGTVRVTLPPVSWTAVHVK
>NZ_CP006741.1|WP_007055304.1|2044474_2045275_-|transglutaminase-family-protein
MKKLVFDYEMRLSFSAPVTDHRFQLRCIPSTGPRQQVIDVEVKIQPETELETTIDSFDSVVMTGFIPEPHDIFSYSVTGIAFVDNAHIHKEAYKPLYRFNSALTIPGPNVEAMIAVCRERLAALPSDATPVQQAAEVMDEVYKAFVYTPGSTTIRTTAEQALAQRKGVCQDYAHVMLSVCRHVGLTARYIAGLLGGEGATHAWVEVYQDGRWVGLDPTHNRLVDDSYITIAHGRDYRDCMLDIGIFSGYNVQQSQWVNASVHEQVA
>NZ_CP006741.1|WP_038426544.1|2045481_2047662_-|circularly-permuted-type-2-ATP-grasp-protein
MIESAARRLAHELVNRREAINRELSRNGVRFGIYKNGEYHDRLFPYDPVPRIIESDEYDELEKGLKQRVNALNAYLKDIYSDKAIIHDGVVPEEYVYTSAGYFPQVNGVTPPGGIFAHIAGEDLVQGEDGRWWVLEDNLRIPSGASYPLFVRDIERRISPRLFRDVRIRDNREYPRLLRKAMDFVSTEGIAVVLTPGRYNSAFFEHAYLAEKTGAALAFPEDLEVVDNKVYFLDYAGKRHRVGVVYRRLSDEFLDPFAFNPDSVIGVPGILSAYRAGNVAIVNAPGNGAADDKAVYYFVPQMIKYYLGEEPILNNAPTYMPMFEADRKEVLNRMGELVIKDVAEAGGYGVVFGSSLDAAAREELANRIKEEPRRFIAQEVIQFRDIDVVDPKTGEMSPRKCDLRAFVVTGKNTHVWYSGLTRYSSVPGQMIVNSSQGGGFKDTWVLAPESGVEHEYGAETQVANLLSQSRHHSLSLVTASKADNLYWLGRYTERAFTTLNQFFPFYDRVMDTDVDAFRPFAHALDLPEDFEDFDGFVNSFLYDGSNPDSVRSAVTSAFNNAVILRPELSSRLLQYVELAMTNITDAAKYAADAEDIYKQRDITDDMLAFWGGIENSPVDPTLKAFIFIGKYLERIDLYTRFGLTMEDLEAPLKKLAAYSMTLDGMPLPSCFADGLSWLVGQLPSRGYQEVADLLKKYLDDYSGRVSALAIKDMGSLSSMNMDAKRP
>NZ_CP006741.1|WP_007053050.1|2047955_2048867_+|tRNA-pseudouridine(38-40)-synthase-TruA
MTRLRIDLAYDGGGFYGWAKQPNLRTVQGTIEDALHKVLRVPTDDAAEPLRLTVAGRTDTGVHASHQVAHLDVSDEVLNRCVGHMTIPVTEALTRRLKAVLPSDIVIHGIAVAPVGFDARFSALERTYVYRVADRSSEVDPRLRGCVLTVDEALDLELMNRAASLTIGLHDFGSFATPNPGGTTIREVKTAYWRRVPITPLVPDEMASHEAYRTPSLESGLVVFTIVADAFARNMVRSLVGSCIKVGSGRKSLEWFAGKMAEPVREGSSGPIAPQGLTLEHIAYPADDQLAARAEAIRAVRTL
>NZ_CP006741.1|WP_007053049.1|2048948_2049491_-|50S-ribosomal-protein-L17
MPTPKKGPRLASSPAHERLMLANMATSLFQNGRITTTLPKAKRLRPLAERLITFAKRGDLHSRRRVMRVIRNKSVVHILFTQIAEQMEQREGGYTRIVKIAPRVGDAAPAAVIELVTEPVAKKAVVKEAEAAAKVAEEEAPAVEAEATEAAEAVEAPVEETAAAEAEAPAEEAADAEKAE
>NZ_CP006741.1|WP_007053048.1|2049590_2050586_-|DNA-directed-RNA-polymerase-subunit-alpha
MLIAQRPTLTEESLNPQRSRFTIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSVRISGALHEFTTLPGVQEDVTEILLNIKGIVLTSEYDEPVVMYLRKSGKGEAVAGDITPPAGVTIANPEQHIATLADDGELEIEFTVERGRGYVPAQMNKQDNDEIGRIPVDSIYSPVLKVSYKVEATRVEQRTDFDKLILDVETKPAISPRDAVASAGSTLVELFGLCRELNAQAEGVEVGPAPVAEETNPEMAVPIEDLNLTQRSYNCLKREGIHTIGELVSHTEQDLLDIRNFGMKSIDEVKEKLQTLGLSLKSSPMAFDTNNLEGGTFFSPEDE
>NZ_CP006741.1|WP_003829907.1|2050666_2051065_-|30S-ribosomal-protein-S11
MAAPKQAARKPRRRDRKSVPVGQAHIKSTFNNTIISITDPSGAVVSWASGGDVGFKGSRKSTPYAAGMAAESAARKAMEHGVKKVDVFVKGPGSGRETAIRSLQSAGLEVGSITDVTPQAHNGVRPPKRRRV

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Crispr_ID: NZ_CP006741_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP006741_4

2191557-2191630

Orphan

Consensus_repeat	Method
AAATGACGAACCGGGACAGCGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP006741_4

>merge|NZ_CP006741|4|2191557-2191630|CRISPRCasFinder
AAATGACGAACCGGGACAGCGAAATCTGTCCCGGTTGTCCCAAAAGAGACGAAATGACGAACCGGGACAGCAGA

>NZ_CP006741|4|4|2191557-2191630|CRISPRCasFinder
AAATGACGAACCGGGACAGCGAA	ATCTGTCCCGGTTGTCCCAAAAGAGACG
AAATGACGAACCGGGACAGCAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP006741.1\|WP_007053060.1\|2179244_2180936_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237045
NZ_CP006741.1\|WP_007053077.1\|2200330_2201596_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP006741.1\|WP_022527887.1\|2190537_2190714_+\|DUF1778-domain-containing-protein	unknown	unknown	unknown
NZ_CP006741.1\|WP_038426568.1\|2195984_2197577_-\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143501
NZ_CP006741.1\|WP_032741682.1\|2181735_2184804_-\|Rne/Rng-family-ribonuclease	unknown	unknown	gnl\|CDD\|273254
NZ_CP006741.1\|WP_007053062.1\|2181275_2181584_-\|50S-ribosomal-protein-L21	unknown	unknown	gnl\|CDD\|235510
NZ_CP006741.1\|WP_007058795.1\|2188993_2190088_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP006741.1\|WP_007055074.1\|2178110_2179244_-\|glutamate-5-kinase	unknown	unknown	gnl\|CDD\|235460
NZ_CP006741.1\|WP_007056295.1\|2204010_2205336_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NZ_CP006741.1\|WP_007056290.1\|2199656_2200322_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP006741.1\|WP_038426566.1\|2191709_2193164_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|178901
NZ_CP006741.1\|WP_007053066.1\|2187548_2188997_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225669
NZ_CP006741.1\|WP_007056294.1\|2202708_2203962_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224090
NZ_CP006741.1\|WP_007053065.1\|2186428_2187373_+\|AEC-family-transporter	unknown	unknown	gnl\|CDD\|223751
NZ_CP006741.1\|WP_007053081.1\|2205584_2206931_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|181958
NZ_CP006741.1\|WP_015713887.1\|2201682_2202615_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP006741.1\|WP_007056289.1\|2194507_2195824_-\|homoserine-dehydrogenase	unknown	unknown	gnl\|CDD\|235783
NZ_CP006741.1\|WP_007053061.1\|2181004_2181253_-\|50S-ribosomal-protein-L27	unknown	unknown	gnl\|CDD\|235464
NZ_CP006741.1\|WP_038426567.1\|2193300_2194413_-\|homoserine-kinase	unknown	unknown	gnl\|CDD\|234920
NZ_CP006741.1\|WP_007053064.1\|2185116_2186322_-\|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl\|CDD\|349899

Protein	Function_ID	Function_description	E-value
NZ_CP006741.1\|WP_007053060.1\|2179244_2180936_-\|GTPase-ObgE	gnl\|CDD\|237045	PRK12296, obgE, GTPase CgtA; Reviewed.	0
NZ_CP006741.1\|WP_007053077.1\|2200330_2201596_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.26608e-49
NZ_CP006741.1\|WP_032741682.1\|2181735_2184804_-\|Rne/Rng-family-ribonuclease	gnl\|CDD\|273254	TIGR00757, Ribonuclease_E/G-like_protein, ribonuclease, Rne/Rng family. This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome. [Transcription, Degradation of RNA].	1.27282e-153
NZ_CP006741.1\|WP_038426568.1\|2195984_2197577_-\|diaminopimelate-decarboxylase	gnl\|CDD\|143501	cd06828, PLPDE_III_DapDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase. Diaminopimelate decarboxylase (DapDC, EC 4.1.1.20) participates in the last step of lysine biosynthesis. It converts meso-2,6-diaminoheptanedioate to L-lysine. It is a fold type III PLP-dependent enzyme that contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. DapDC exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	3.51605e-72
NZ_CP006741.1\|WP_007053081.1\|2205584_2206931_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|181958	PRK09564, PRK09564, coenzyme A disulfide reductase; Reviewed.	4.86961e-92
NZ_CP006741.1\|WP_007053062.1\|2181275_2181584_-\|50S-ribosomal-protein-L21	gnl\|CDD\|235510	PRK05573, rplU, 50S ribosomal protein L21; Validated.	3.48911e-33
NZ_CP006741.1\|WP_007058795.1\|2188993_2190088_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	5.4425e-101
NZ_CP006741.1\|WP_007055074.1\|2178110_2179244_-\|glutamate-5-kinase	gnl\|CDD\|235460	PRK05429, PRK05429, gamma-glutamyl kinase; Provisional.	4.59837e-176
NZ_CP006741.1\|WP_007056295.1\|2204010_2205336_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NZ_CP006741.1\|WP_007056290.1\|2199656_2200322_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	7.0971e-17
NZ_CP006741.1\|WP_038426566.1\|2191709_2193164_-\|NUDIX-domain-containing-protein	gnl\|CDD\|178901	PRK00148, PRK00148, Maf-like protein; Reviewed.	2.17759e-59
NZ_CP006741.1\|WP_007053066.1\|2187548_2188997_-\|hypothetical-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	9.90267e-07
NZ_CP006741.1\|WP_007056294.1\|2202708_2203962_+\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224090	COG1168, MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism].	1.09465e-119
NZ_CP006741.1\|WP_007053065.1\|2186428_2187373_+\|AEC-family-transporter	gnl\|CDD\|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	1.33178e-36
NZ_CP006741.1\|WP_015713887.1\|2201682_2202615_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.80874e-31
NZ_CP006741.1\|WP_007056289.1\|2194507_2195824_-\|homoserine-dehydrogenase	gnl\|CDD\|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	0
NZ_CP006741.1\|WP_007053061.1\|2181004_2181253_-\|50S-ribosomal-protein-L27	gnl\|CDD\|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	3.06993e-50
NZ_CP006741.1\|WP_038426567.1\|2193300_2194413_-\|homoserine-kinase	gnl\|CDD\|234920	PRK01212, PRK01212, homoserine kinase; Provisional.	1.91509e-87
NZ_CP006741.1\|WP_007053064.1\|2185116_2186322_-\|succinyl-diaminopimelate-desuccinylase	gnl\|CDD\|349899	cd05647, M20_DapE_actinobac, M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase. Peptidase M20 family, actinobacterial dapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) subfamily. This group is composed of predominantly actinobacterial DapE proteins. DapE catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelate (L,L-SDAP) to L,L-diaminopimelate and succinate. It has been shown that DapE is essential for cell growth and proliferation. DapEs have been purified from proteobacteria such as Escherichia coli and Haemophilus influenzae, while genes that encode for DapEs have been sequenced from several bacterial sources such as the actinobacteria Corynebacterium glutamicum and Mycobacterium tuberculosis. DapE is a small, dimeric enzyme (41.6 kDa per subunit) that requires 2 atoms of zinc per molecule of polypeptide for full enzymatic activity. All of the amino acids that function as metal binding ligands are strictly conserved in DapE.	0

>NZ_CP006741.1|WP_022527887.1|2190537_2190714_+|DUF1778-domain-containing-protein
MTSLQWALSNLLAAADRDIHEAHIIRLNSKAWNDFTAALNEPMGLRLNELLERDPIWT
>NZ_CP006741.1|WP_007058795.1|2188993_2190088_-|ABC-transporter-ATP-binding-protein
MNTAASQLQQPQPAPGPAAQPQQSQQPQQFQQPASHTQQWAPVIEAHDLVMDYTASMARAQAGHGVTGVIPAGTGAGYASANPAAAGPGAIQAGQPSQPAQPGFAMPTMHTLALNHVNFTLREGETVAVMGPSGSGKSTLLHALAGIIKPTAGTVIFRGADLSRMSDAERTKLRRNDFGFVFQSGQLLPELPAVENIALPMMLDGMPYRTATDTAILWLERMGLRALATHRPGEMSGGQMQRIAIARALAVKPAVVFADEPTGALDQATGREVMGILMAAARDNGSAVVVVTHDPNVASFCGRTVMMQDGRLHQTDANPNSAPAGGGCQPQADWGWPEGAEPPSASLRSAAPAGGSETTAGGAR
>NZ_CP006741.1|WP_007053066.1|2187548_2188997_-|hypothetical-protein
MSTFALWRLFHRPGLRGSAGHTSMLAIIAFAAATTIFLTVLGGVHGFIWRASADHTVACAFDFGACRPDTVAAWKRQISDPTSLAQFSTAYVALAVFACMLLVVPFVALAGSAARLAASRRDARLAALRLAGATTGQVVRLTALDAAGQALIGALIGIAGYCALMPAVMLIPFQEQRFTFEQLWVGPLALVITLAGVAILALISSLVTLRRVAITPLGVTSRTATALPSGTRMVLFVVVVVVAMIVFKNPAMLAQAGQAVMYGVIIGFMLLCFALVNLIGTWVITARAKAKAKRPKDAATMIAMRRILDNPKRAWRNVSGIALAVFIAGITSICGFFGSAAVVDDANDPFTVFIRDIGTGGILTLVFAAVLAAVSSGVMQAGSVYDQAGEYRMLVLEGTDVKTLNRARFIEVLTPLNIVVIVAGGCSMLLMAPLFAASMTEPATLASFFGGLVLCYALVSIGAFASNHVAASLNLTDYRADD
>NZ_CP006741.1|WP_007053065.1|2186428_2187373_+|AEC-family-transporter
MPGLISAMQGFCVIGIVIAVGYVAARMRIGGPSAQMVLNRFSFFVSSPCLMFAILSKEPIFDIFHPSIIVAFFSAVLVGVVFLVLNRMFFHLNAPDATIGALNSLYLNSNNIGLPIATYILGNPALVAPILVMQQAIFTPVGLTVLDVTTKGKVSIKEIAKQPLHQPLLIGSLLGIVVSAISAKSGWFPVPKFIFDPIDMIGDSAVPMILMAFGMSLHGTKPLQQKGDRPAIFTVAVLKNIIMPIIAFLLAYFVMGFRGSELYACVVLAALPTGQNVYNYAARYNVGLTFARDGILMSTMTSPVFIAIIAALLS
>NZ_CP006741.1|WP_007053064.1|2185116_2186322_-|succinyl-diaminopimelate-desuccinylase
MTLELNRTASTAEQLNSLLTQIMENFSVSDHEGPLTDEVEAFLNEQEHLTVRRHGDTVVASTDFGKPSRVILAGHLDTVPVIDNFPPKWLEPGDSLIREEIAHAHPEDRVLWGRGATDMKASDAVMLYLAATLDGRTPETTPKVDLTYVFYDHEEVVAEKNGLRKVVEAHPDWITGDFAIIGEPTNSGIEGGCNGTIRFDVVTHGVAAHSARAWMGENAIHKAADILNRLNAYEPATVNVDGLDYREGLNATLISGGKGTNVIPDECRVHVNYRFAPDKSLAEAKALMMGADAGAELGNGEHVATGGVFEGYGIEMKDESPSARPGLNAPLAQDLVRLVKERTGRDPLAKLGWTDVARFSQLGIPAVNLGAGDPLLAHKHDEQVPESDLTAMAAILTDWLV
>NZ_CP006741.1|WP_032741682.1|2181735_2184804_-|Rne/Rng-family-ribonuclease
MQRAARSIVPTDNREGFVNDGTDNSTVSNADSAAAVNAAPAAASQPAEPVRRRRGGRRVVRGTGAAGASLELQVQERAPLFEAPALPDAGTAADSKSADSSDSDESSDSQDSAERPTRRRSRRAASAVADSDSEDDRPRRSRRTVSADDFDDDDAPRSRRRSVVDDDDYDEDRPVRRRSRSRQSDDDDYEDRPVRSRSRRASMDMDDDDEDRPVRRRSRRAVADTHEDTPDERLFDAVESLPSGHEAVRRGKPMTSLLFQEPVLPAAVDAHDTADTRDDDVDDDERPSRRSRRSRSHDDDDAQPRSRRRDDRDDRGRNAADRDTSRDASRNAAAGDANASANTDHDDFDSDDASDSRRSRRSRRLNAQERRAAAEVEQIEEDLELDDIAYSPIAEEEGDEESDATRTRSRRRRRRGSRGETGANGEHDTAENDAEDTRSRRRDDRDDHDRDRDEDDEEQTVTRRRRRRRGGKNGEGTDDQSQNSEQPLVRRSRKQQYIDEITDVEGSTRLEAKKQRRRDNRRERSRQSQLMEQDFLARRENVDRLMVVREKEHHTQISVVEDNVLVEHYVSDIQEVQTVGNIYLGRVQNVLPSMEAAFVDIGQARNGVLYAGEVNWDAARLEGQPRRIELAFKSGDPVLVQVTKDPIGHKGARLTSQVTLAGRFLVLVPSGGMTGVSRKLSERERSRLKNIVSKIAPKDMGVIIRTAAEGASEDAIVKDLESLVRQWERINAKREEFWHGKRPKLLQGEPDVAIRVVRDIFNDDFSKLIVEGDKVYDRIEEYLDTMAPDLKDKLEKWDPAEHEGKDVFDKWSIDSQLRKGMERQVYLPSGGSIVIDRTEAMTTIDVNTGRFIGKGKSLEETVTRCNLEASEEIARQLRLRDIGGMVMIDYVDMVMPANRDLVLRRLVECLARDRTKHQVAEVTSLGLVQMTRKRIGQGLVEAFSEECPTCKGRGFILHDQPTVSADYDDPYALRGGDPFVKTNKHGRGTAPAPEPAGSSADVKAKLAQIAAAAVAANNTAEE
>NZ_CP006741.1|WP_007053062.1|2181275_2181584_-|50S-ribosomal-protein-L21
MYAIVKAGGHQEKVEVGDVILVNRLDAKKGDTVEFPVSLVVDGDKVTLAAADLAKVSVKAEVVNDEAKGPKISIQKYKNKTGVARRKGHRQKLTIVKITAIA
>NZ_CP006741.1|WP_007053061.1|2181004_2181253_-|50S-ribosomal-protein-L27
MAHKKGASSSRNGRDSNPQYLGVKKFGGEAVVAGNIIVRQRGTNFHPGHNVGMGKDHTLFALTDGSVKFGVRRDRKVVDVIA
>NZ_CP006741.1|WP_007053060.1|2179244_2180936_-|GTPase-ObgE
MSDFVDRVTVHVKGGDGGNGSAGIRREKYKPLAGPNGGNGGDGGSVVFVADRNATSLLDYRFMPHRVAGSGTMGLGDNKDGSKGEDLILPVPCGTVVFEARGEQGKAKHPGAQLADLRHEGDRCVVAQGGAGGLGNIALANKTRRAPGFALLGELGEERDVILELKSIADVALVGFPSAGKSSLIAAMSSAKPKIADYPFTTLVPNLGVVIAGDSRYTIADVPGLIPGASEGKGLGLEFLRHIERTEIIAHVIDCATLEPDRDPMSDYHALENELALYADKLELPLGAIPIPERPRIVILNKIDVPEAKELAEFVRPEFEKLGLKVFEISTASHEGLKELNFALSALVHEMREEVANREQAEEEARVVIKPLETKGRRPRRADEGGSALEFTVERRELGNGEVFFEVRGVKPERWVMQTNFDNDEAVGYLADRLAKLGVEDELRRKGAHPGDEVRIGRGARMVEFDWDPTISAGAEMLDGSNLGARGKDLRLEELDPRTHRRSNAERRAQYHEMMDARAAVRDAMMAERKAGHWADPTVDDDRHDETSLFGHGESSEDGETEE
>NZ_CP006741.1|WP_007055074.1|2178110_2179244_-|glutamate-5-kinase
MSTPSQAEVRRMIAAAGTIVVKVGSSSLTQPSGHLDPDKLDALAAALAQVRLMGGRVVLVSSGAIAAGFGPLGFDSRPVDVATQQATAAVGQGLLMARYETAFGRFGIRVGQILITAEDTIRATQYRNVERTLDRLLDLGVVPIINENDSLASNEIRFGDNDRLSALVANLVRAEALVLLTDVDALYTAPPSQPGSRRVEYVPNVIDALGDIQVSGSGSKVGTGGMVTKLEAARVAAVSGIPTVLTCASNAGPAMMGDPVGTVFAPVKARGSSRRLWIGFAADPRGTIVVDAGAGQAIRGGRASLLAAGALEVHGDFSAGDPVWIDAESGEHLARGLAGFDSEEIPQMLGRNTAQLKRFLGPQYAHPLVHRDNLVLV
>NZ_CP006741.1|WP_038426566.1|2191709_2193164_-|NUDIX-domain-containing-protein
MPIPLILASKSKPRRDVLYSAGICPTIRVSHVDEPAALEAAAREEGVTVDDLSIKQRVMILAAAKAEAVHRAYRDVADTAAAATGDRVIAYPLKAKEIKDSEREAAVEDLREAAAGKPIDYSKAEIATTRDFSGIDMPTVTEPIATAIAGQPGLTEATVGPLILGCDSMFLLGGECYGKPHSEAVARERLKRMSGATGELWTGHCLIDFATGRTVRGASHAKVHFGEFTDDDIERYIVTGEPLEVAGSFTLEGFGGAFIDSIEGDPHGIIGLSLPLARHLAGELGITWTDLWNVGRGELEPESKASGNQHAGILPPVENVHQPGDGWVDCACGRKHWGTNGASGILLARRDPASGKVTHVVMQHRAAWSAEGGTWGIPGGATADGESPIEGALRESYEEANITPEDIEVVGSYREDHGPWAYTTVFAFEKPGHTVEPKANDDESMEICWVPIDDVPNRKLLTAMKTDWPRFAARLDELACAGHR
>NZ_CP006741.1|WP_038426567.1|2193300_2194413_-|homoserine-kinase
MNPICNSVHVRVPATSANLGSGFDTVGLALDYHDELTFTLNDDPNDGIAHVIIHGEGADALPCDETHLVVSTFRRACATFGLGRLGFTLEATNNIPQARGMGSSAEAIVAGIAAAAAFAQTGDLNRPAIFDMAAQIEGHPDNVAPAVFGGLTVSWDFETAEGVGSVAVPGGEPLHGGFHAVNYPVDPSITAAVFVPDYELSTEKARQALPRELPYKDAVYNVSRVGLLPAAMNPVVLAQAAQQGKSGVAAAPAQDADTCACSGGTRESAFADELAAAQAQSNALLFTATQDKLHQPYRGALMPPSTELIALFRSKGYAAAVSGAGPCVLVLHYGNAREAIDQIASEQLASGHWRVLHLPINTAGVEIERR
>NZ_CP006741.1|WP_007056289.1|2194507_2195824_-|homoserine-dehydrogenase
MARNNETPIRVGLLGAGTVGSQTARLIVEQKDELSARIGRPVELTGVACLDPKETEKFPWIDQSIVTTDTLSVATNSDIVIELIGGTTVARKFVLAAIESGASVVTANKALLAKYGPEIYSAAEAKGVDIYFEAAVGGAIPFLRPLRESLVGDKVTSMLGIVNGTTNYILDEMTTKGLQFDDVLKDAQAKGYAEADPTGDIEGYDAANKAAIMATLGFHTSVTIDDVSVEGITKITADDIAAATAEHKVIKLLAVVENGEAGVSARVYPALIDENHPLASVHGSFNAVFVKAEAADDLMFYGRGAGGAPTASAVVGDVVTEARHIAAGCTGPSIPLYKNLPKAPITASKAAFAVRFLIHDKPGVLAAIAAEFAKNGVSINGVNQDLKPTMTDPGYDGEIQQLRVVTHLTDEETLRNTVKAVQALDFVTGDPSILRVLD
>NZ_CP006741.1|WP_038426568.1|2195984_2197577_-|diaminopimelate-decarboxylase
MPISPIWPAATAVNAEGSIEFHGRTAESLLDEFGSPLYLIDTDEVVARARHFVRAAAEAFNTSTTHVSFAGKAFLSKEVVRLVTEAGMFVDTCTMDEMKIALAAGVPGRRLVLHGNNKSDEEIALAIEQGFAKIVIDEPDEPERVAAIARKLGKRARVMLRVTVGVHAGGHEYISTAHEDQKFGVPLLAAGADAAVLDVLNDLKDVTPAATNARISATHSPENGAEKTEKSERELHYDVKYPYDLSHEEVSDTDKALAAAMEAIADGPSIAVLKTILANQDVLELVGAHSHIGSNIHDADAFIHAAKRMMLLRKTLWATDAYILPEIDLGGGYSVAYTDGEDSMDIDVELTRLADAVNSTNRALGMPAPAISFEPGRYIVAPAGVTLYRVGTIKHVHLSDAKDSDGNPIAERVYVSVDGGMSDNIRPALYGADYTARLANRTGSAETMLARVCGMHCESGDIVVHEVQLPADLKRGDILAVPVTGAYGRTMASNYNQALIPAVVAVSESGAHVMLRRQTVDDLLNLDVSE
>NZ_CP006741.1|WP_007056290.1|2199656_2200322_+|TetR/AcrR-family-transcriptional-regulator
MARNAHPEVTRTRILDAAQRLFMAQGYEHTSIQDIVDELGDLSKGAIYHHFKSKEAILEELTNRDNNMQDDFNESVMNRTDLTALEKFRVLWRHSMTKQDHVQIMRAAMPMLSDPVSFAANMQVWSKHLPERFLPLIEAGVKDGSIPTEYPREAAELLSLLPNYWLMPYFYPVTLPEMEHRIRCLATMLDAIGVPIFDDELITVAAKGMMTFAGEPEKGSE
>NZ_CP006741.1|WP_007053077.1|2200330_2201596_+|MFS-transporter
MKPENDIAGTATQRPLLSRDFVLLVAGQGISLFGNVMLRFAMSMWVLDETGSATIFASVLAISIVPTILLSPFGGVLADRVNRRTIMVALDAISAVLVLASAIVFATTGFHIVAIATMQVLLAVLGAFETPTVQAALPQMFRQYGPATMRQGMAVINQVQQLSSLLPSFLGGVLYAMFGIRLMMIIAIASFAGAAALECFIRLSAPDRGDEELPTPLEDLKAGVRFLIKDRPNVFRLLLFAAALNFVLIGYSGVGFPYTIRTVLGFDATVYGIADGLIGVSGVAGAFIAGLFAAKLTMRWLPGLMATLTLAMVPQGIVFLLPVDAWTKLVVLIVFTCGTMVASCFTNLIAVPAIQLSTPEAMAGKVMSMAAAVSMCAQPLGQMVYGWAYDQMPVAIVLFITTALFAVLTVLMVPLAKQFED
>NZ_CP006741.1|WP_015713887.1|2201682_2202615_+|LysR-family-transcriptional-regulator
MATLNPQSLVTLWQIEQYGSFSATAKATGWSQPAISQQIKKLEAQCGSTLVQRTSHGVELTATGSMLARHGEAIADRLERAAREVEDYRHHRFAHLHLVAPPSICSTIAARTVVKLSMFTDIELSLIQMEPPEAIGLISQGKADAAAVFRYSSIPNFLHIGDDLTFQSLGYDPMRLLVRRSSDIAKRFEETGEPVPLSAAKDEHWIAGCPTCRANLVKLATRAGFKPDIRHCTDDYWATQNLVEVGMGVSLVPALDTHINLQGDLVACPIADDFAAREVGIVTRAGDHRPALGSLLEELERTSLKYLSAK
>NZ_CP006741.1|WP_007056294.1|2202708_2203962_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MSMNNIPQSTTLSNTTAGTSCFDANHIDVTTIEDLEQVGSDKWTRYPGCIGAFIAEMDYGLAPCVAEAIEEATERGALGYIPDPWKKEVARSCAAWQRRYGWEVDPTCIRPVPDVLEAFEVFLREIVRAGNSIVVPTPAYMPFLSVPRLYGVEVLEIPMLCAGAGESSGRNDEWLFDFDAIEQAFANGCHAFVLCNPHNPIGKVLTREEMLRLSDLAAKYDVRIFSDEIHAPFVYQGHTHVPFASINRQTAMQAFTSTSASKSFNIPGTKCAQVILTNPDDLELWMRNAEWSEHQTATIGAIATTAAYDGGAAWFEGVMAYIERNIALVNEQMRTRFAKVRYVEPQGTYIAWLDFSPLGIGDPANYFFKKANVALTDGRECGEVGRGCVRMNFAMPYPLLEECFDRMAAALEADGLL
>NZ_CP006741.1|WP_007056295.1|2204010_2205336_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MAENPDDVLHVEGGKPLNGTIKVRGAKNFVSKAMVAALLAPGKSVLKNVPEIRDVHVVSDLLRLHGVDVDVDGANGIVTIDASRVQLADVADVDTLSGSSRIPILFSGPLVHRLGEAFIPALGGCAIGGRPIDFHLETLRKLGATVDKEHKDGIHITAPNGLHGAKIHLPYPSVGATEQTLLAAVLAEGKTELSGAATEPEIMDLVCVLQKMGAIISVDVDRTFRIEGVKELQGYTHTSLTDRIEAASWASAALATHGDIFVKGATQPEMITFLNVFRKVGGKFEVTDKGIRFWHPGGDLKPVAIETDVHPGFMTDWQQPLVVALTQANGLSIVHETVYENRFGFTKPLVEMGATIQLYRECLGSLPCRFRQRNYKHSAVIFGPTPLTGRDIDVPDLRGGFSHLIAALAASGPSDVHGISLIDRGYADFRGKLEALGADFD
>NZ_CP006741.1|WP_007053081.1|2205584_2206931_+|FAD-dependent-oxidoreductase
MTTVAVIGCTHAGTFATTSILAEHPDWTVHVFERNGTLSFLSCGIALWVGDHVSDPKKMFYSSPAALAEAGATMHMRTDVTSVDLDARTLTYRALDEAGDPAEQTLAFDKLVVTTGSRPVIPPIPGIDSPHVLLCKNWDHAIAIKEKAKTAKSAVVIGSGYIGAEIAEQFSVTGVKTTLVDGLDRPLANNFDKTITDQVAAAFEEHGVTLALGQKVVEFRDNDDDTVTVVTEKGEYTAEMAILAVGFLPNTDLLKGKVDMLPNGAIVVDDYMQASAPGVYAAGDSATVFYNPTGQHDYIPLATNAVRQGLLVGRNIETPTVKYMGTQATSAVQLYDLSLAASGLTRAGAERRGLTVRETSLTEDYRPDFMLTTTPVTSILTWDPETRKVKGGQFCSKADISGAANVISMAIQAGFTIDQLANVDFLFQPNFDKPVYYVGAVAMKAAAE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP006741_1	1.5\|245577\|24\|NZ_CP006741\|CRISPRCasFinder	245577-245600	24	NZ_CP047177	Rathayibacter sp. VKM Ac-2759 plasmid unnamed1, complete sequence	98015-98038	3	0.875
NZ_CP006741_1	1.5\|245577\|24\|NZ_CP006741\|CRISPRCasFinder	245577-245600	24	NZ_CP013110	Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence	1789555-1789578	4	0.833

1. spacer 1.5|245577|24|NZ_CP006741|CRISPRCasFinder matches to NZ_CP047177 (Rathayibacter sp. VKM Ac-2759 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.875

atcggttccgcagccggctgccgg	CRISPR spacer
atcggttccgcagcgggcagccgt	Protospacer
************** *** ****

2. spacer 1.5|245577|24|NZ_CP006741|CRISPRCasFinder matches to NZ_CP013110 (Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence) position: , mismatch: 4, identity: 0.833

atcggttccgcagccggctgccgg	CRISPR spacer
gtcggttccgccgccggctgcctc	Protospacer
.********** **********

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage