CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP010520	Clostridium botulinum strain NCTC 8266 chromosome, complete genome	6 crisprs	cas3,csa3,DEDDh,WYL,DinG	1	1	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP010520_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010520_1

367470-367567

Orphan

Consensus_repeat	Method
CAATTGTTAATATTATAACAATT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP010520_1

>merge|NZ_CP010520|1|367470-367567|CRISPRCasFinder
CAATTGTTAATATTATAACAATTGGCGACAATTGTTGACATGATAAGACTAATGTAAGCCTTTTATTTTTAAATTCAATTGTTAATATTATAACAATT

>NZ_CP010520|1|1|367470-367567|CRISPRCasFinder
CAATTGTTAATATTATAACAATT	GGCGACAATTGTTGACATGATAAGACTAATGTAAGCCTTTTATTTTTAAATT
CAATTGTTAATATTATAACAATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010520.1\|WP_012449804.1\|355610_357014_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NZ_CP010520.1\|WP_012450450.1\|376634_378050_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP010520.1\|WP_012449595.1\|374252_375737_+\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|274983
NZ_CP010520.1\|WP_003373302.1\|370521_371529_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NZ_CP010520.1\|WP_012450317.1\|375935_376631_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP010520.1\|WP_012450991.1\|372640_373075_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213664
NZ_CP010520.1\|WP_012449470.1\|362932_363514_+\|zinc-dependent-phospholipase-C-family-protein	unknown	unknown	gnl\|CDD\|376406
NZ_CP010520.1\|WP_003371045.1\|368559_369699_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NZ_CP010520.1\|WP_003372943.1\|367696_368479_+\|short-chain-enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|180270
NZ_CP010520.1\|WP_012451188.1\|360162_361377_+\|zinc-chelation-protein-SecC	unknown	unknown	gnl\|CDD\|234966
NZ_CP010520.1\|WP_012450139.1\|359151_359994_+\|patatin-family-protein	unknown	unknown	gnl\|CDD\|132847
NZ_CP010520.1\|WP_012451489.1\|354415_355606_+\|electron-transfer-flavoprotein-subunit-alpha	unknown	unknown	gnl\|CDD\|224936
NZ_CP010520.1\|WP_003370953.1\|366715_367348_+\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|235486
NZ_CP010520.1\|WP_003369662.1\|371632_372481_+\|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|180269
NZ_CP010520.1\|WP_012449787.1\|363638_364004_+\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NZ_CP010520.1\|WP_012451618.1\|361591_362659_+\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|223906
NZ_CP010520.1\|WP_040968257.1\|369716_370499_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|224997
NZ_CP010520.1\|WP_012449992.1\|353524_354313_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|224997
NZ_CP010520.1\|WP_012451791.1\|373164_374091_+\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NZ_CP010520.1\|WP_012450485.1\|364021_366283_+\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319847

Protein	Function_ID	Function_description	E-value
NZ_CP010520.1\|WP_012449804.1\|355610_357014_+\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	8.44699e-132
NZ_CP010520.1\|WP_012450450.1\|376634_378050_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	7.33118e-53
NZ_CP010520.1\|WP_012449595.1\|374252_375737_+\|4Fe-4S-binding-protein	gnl\|CDD\|274983	TIGR04105, hypothetical_protein, [FeFe] hydrogenase, group B1/B3. See for descriptions of different groups.	0
NZ_CP010520.1\|WP_003373302.1\|370521_371529_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	5.95728e-138
NZ_CP010520.1\|WP_012450317.1\|375935_376631_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	5.35095e-75
NZ_CP010520.1\|WP_012450991.1\|372640_373075_+\|hypothetical-protein	gnl\|CDD\|213664	TIGR01909, Uncharacterized_protein_AF_0456, C_GCAxxG_C_C family probable redox protein. This model represents a putative redox-active protein of about 140 residues, with four perfectly conserved Cys residues. It includes a CGAXXG motif. Most members are found within one or two loci of transporter or oxidoreductase genes. A member from Geobacter sulfurreducens, located in a molybdenum transporter operon, has a TAT (twin-arginine translocation) signal sequence for Sec-independent transport across the plasma membrane, a hallmark of bound prosthetic groups such as FeS clusters.	1.20592e-30
NZ_CP010520.1\|WP_012449470.1\|362932_363514_+\|zinc-dependent-phospholipase-C-family-protein	gnl\|CDD\|376406	pfam00882, Zn_dep_PLPC, Zinc dependent phospholipase C.	7.98672e-18
NZ_CP010520.1\|WP_003371045.1\|368559_369699_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
NZ_CP010520.1\|WP_003372943.1\|367696_368479_+\|short-chain-enoyl-CoA-hydratase	gnl\|CDD\|180270	PRK05809, PRK05809, short-chain-enoyl-CoA hydratase.	2.14628e-173
NZ_CP010520.1\|WP_012451188.1\|360162_361377_+\|zinc-chelation-protein-SecC	gnl\|CDD\|234966	PRK01617, PRK01617, hypothetical protein; Provisional.	2.39383e-11
NZ_CP010520.1\|WP_012450139.1\|359151_359994_+\|patatin-family-protein	gnl\|CDD\|132847	cd07208, Pat_hypo_Ecoli_yjju_like, Hypothetical patatin similar to yjju protein of Escherichia coli. Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	5.54826e-106
NZ_CP010520.1\|WP_012451489.1\|354415_355606_+\|electron-transfer-flavoprotein-subunit-alpha	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	1.0431e-117
NZ_CP010520.1\|WP_003370953.1\|366715_367348_+\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|235486	PRK05472, PRK05472, redox-sensing transcriptional repressor Rex; Provisional.	5.84301e-118
NZ_CP010520.1\|WP_003369662.1\|371632_372481_+\|3-hydroxybutyryl-CoA-dehydrogenase	gnl\|CDD\|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	0
NZ_CP010520.1\|WP_012449787.1\|363638_364004_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	7.08396e-22
NZ_CP010520.1\|WP_012451618.1\|361591_362659_+\|NTP-transferase-domain-containing-protein	gnl\|CDD\|223906	COG0836, {ManC}, Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane].	8.1678e-143
NZ_CP010520.1\|WP_040968257.1\|369716_370499_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	3.96179e-88
NZ_CP010520.1\|WP_012449992.1\|353524_354313_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	4.84186e-94
NZ_CP010520.1\|WP_012451791.1\|373164_374091_+\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	4.9617e-51
NZ_CP010520.1\|WP_012450485.1\|364021_366283_+\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319847	cd07548, P-type_ATPase-Cd_Zn_Co_like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell. Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0

>NZ_CP010520.1|WP_003370953.1|366715_367348_+|redox-sensing-transcriptional-repressor-Rex
MDKNKNISMAVIKRLPKYHRYLNELMKNDVDRISSKELGEKIGFTASQIRQDLNCFGDFGQQGYGYNVKELYTQINSILGLDKEYNAVLIGAGNIGQAIANYSRFDKLGIMITAIFDANPKLIGIKIRDIEIRDIDELGSFLKSDSVDIGVICVPKKSAQKVSDELVNGGIRGIWNFAPIDLVVPEDVKVENVHLSESVSTLIYQLHQQR
>NZ_CP010520.1|WP_012450485.1|364021_366283_+|cadmium-translocating-P-type-ATPase
MENEIKLSLKGLDCANCANKIERKVNDMEDVYEADMNFSLGKLTVKLHENKDRDKVFNLIKDIVNKLEPDVIVINEKDNISYNLNTNETNHNNKCNKTCCNHDSCSSHNHEKHHVHSHDNQDNFIETEECEPNSKIKLFDKKKFFYENQIFIIGLILYIIAVLFKENSYLNISIFVLSYILIGGDVLKTAFNNILIGEIFDENFLMTIATIGALAIGEYPEAVGVMMFYKIGELFQGYAVNKSRKSITSLMNIRPEYANVITEYGEKRVSPEEVNIDELIVIKPGERIPLDGIVVEGKGSVDTSALTGESLPREINIDDELLSGSINLSSVIKLKVTKIFSESTVSKILNLVENSSSKKAKTEKFITKFSRLYTPIVVFLAIAVAIIPPIIISGEVFSDWIYRALIFLVISCPCALVISVPLGLFAGIGGASKKGILIKGGNYIEVLKNVDTIVFDKTGTLTKGVFKVTEINSIDMKKEDFLRIVALGESFSTHPIAQSIVKEFNGILEKRYVENYQELSGHGIKAIIEGKNVILGNYKLLEDNNINIEKVEKPGTVVYVVINNKYSGNIVIADEIKEDSIEAINKLKNIGIKKTVMLTGDNKIVANSIGKSIGVDEVKSELLPNDKVLEIEKLISSSTSKGKVMFVGDGINDAPVLARADIGIAMGGIGSDAAIEAADVVLMKDNPTALVDAIKIAKKTNAILWQNIIFALGVKVFVLVLGALGIANMWEAVFADVGVTLIAILNSMRSLKN
>NZ_CP010520.1|WP_012449787.1|363638_364004_+|helix-turn-helix-transcriptional-regulator
MNNETNFVESCKCNIIHEDTVIKVKDSLPQEETLYDLAELFKVFGDSTRIKIICALFESELCVCDMAALLGMTQSAISHQLRTLKSARLVKFRRQGKVIYYSLDDEHIKHIFDEGFKHITE
>NZ_CP010520.1|WP_012449470.1|362932_363514_+|zinc-dependent-phospholipase-C-family-protein
MINTHKLIAENILNNTNSKSIYLINDYRFIWGNIKPDCVLKYKMIKHYFIESIDMIIKKIEKLCSLSLQDVYYKMSVNKFSEELGVICHFICDYFCAPHYYRWEFKNTSQVKNHVMYEKDLAKIAKEFNSNGIITSNIDANNIKEFIYDLQNQYEGSMDFKNDLTYAYYACDSIVNMVLNKVFLNECSLSKVV
>NZ_CP010520.1|WP_012451618.1|361591_362659_+|NTP-transferase-domain-containing-protein
MIYGLILAGGKGSRLYPLSRNSQPKQFLKIINEKSFLVNTVERIKPLIDRENIYVVTNKDYEDKIKEEVQDIKKENIFIEPANKETATCIGLSAVKLLKQDADAVMVVLPSDHYIQGEKEYLDTLSQAVEMANRRRCIVTLGIEPTRPETGYGYIEMGDRSTGNISTYKIARFTEKPNLEVAKDFLLKGTYLWNSGMFVFRADVILREIEKYIPKMHKSLMEIYKYIGEENEEDVVKEQYEIIDGISIDFGVMQKTRKAFVIKCDFNWDDIGSFNALSRFLGKYRSNSISKNVYMEDCESCSVFGEKNLIIGFGIKDLVIVDAGDVILVMDKNKDQEIKHLLNKLSDEDKYNEFL
>NZ_CP010520.1|WP_012451188.1|360162_361377_+|zinc-chelation-protein-SecC
MVKKECSNKDTNNEFIENKETDESAELYDNMMDDLFQKYENKMNKMFVKGVYSFEVSEQLKSLSKEAVYNIAKNLGMSKISTLNKDALIEKVLNEYTEIIANQFIYFEEERFNILKSYLNNDGVKIFDDIDEYELSRTAYFMQQGIIFPSTKDEKAVFLMPKIVQDIITNKDTTEYIDILKRNKEVLDLYRGLNKAYGIVNNKDVTSLLQRYDIENSDEFSINEIIKEAQYYYREYREEKGFFINNNIENWSDLLKDIEKDNKDLEYYNINKNELLDMIGSEWIYKSKFGKSFLKEFTNIFEIKKDMVYQIMDDLSFDIQDNGMDDTINSLLELINANNLELRNHVKGVVTKFLSNIRLWKYRGATINEISGNITEVKPKITIGRNDPCVCGSGKKYKKCCGKN
>NZ_CP010520.1|WP_012450139.1|359151_359994_+|patatin-family-protein
MTGLVLEGGAFRGLFTAGVLDALIDINLEIKYIVGVSAGITNGYSFVSKQRGRNLEVMERFIDHKRYVGYNNLLKCRSIMDMDFVFDEIPNEHCPFDYETFDKFDGKVLAGSVNVNTGEVEYFDKEYLDKKNTILRATCSIPLLFKFININNQLYADGGLVDAIPIKKSISDGNNKNIIVLTRNEGYRKHESKGNKFAYKLYKKKYPKLACVLRDRHIEYNSQIDYCKELESKNEAIVIRPTIEMNVGRFEKNKDKLKEIYNNGYKETMKIKDRLIKFID
>NZ_CP010520.1|WP_012449804.1|355610_357014_+|FAD-binding-protein
MTYKNVEVKDYEYILSIAENDKERVFFGDEINEDYSHDELGGIKKMPDIVVHAISTEEVSKIMKYAYKNSIPVTPRGSGTGLVGAAVPIKGGIVIDLCRMNKILEIDEENLTLTLEPGVLLMEIGKYVEEFDLFYPPDPGEKSATIGGNISTNAGGMRAVKYGVTRDYVRGLEVVMPNGEVVQLGGKVVKNSSGYSLKDLLIGSEGTLGIVTKAILKLLPLPKKSLSLLIPFPTLEKAIDTVPKIIKSKTIPTAIEFMQREAILAAEEFLGKSFPDKSSDAYLLLTFDGNSTEEIEKAYENVANICLEAGAIDVFISDTEERQESIWSARGCFLEAIKALTTEMDEVDVVVPRNKIGEFVKFTHELESKFNIRIKSFGHAGDGNLHIYILKDQLEENVWHEKLELVMKDMYDKSKELKGQVSGEHGIGFAKKPYLKESLSNDVLSVMEGIKLAFDPKNILNPGKIFK
>NZ_CP010520.1|WP_012451489.1|354415_355606_+|electron-transfer-flavoprotein-subunit-alpha
MAKLVVNQEKITNKKELIKICPFGALEINDGKVEINGACKMCKLCVKKGPKGAIEYIEEEVKSIDKDLWKGISVYVDHVNGKIHPVTYELIGKARELAAKINHPVYCVFIGHKVSEEAKELLHYGVNKVFVYDDEELKDFRIEPYAAAFEDFIKNVKPSSILVGATTIGRSLAPRMAARFRTGLTADCTILDIKEDTDLVQIRPAFGGNIMAQIVTPNSRPQLATVRYKVMTAPERTDDVNGEIIKCDIKKDKLKSGINVLEIKEKNTEVGISDAEVIVAAGRGIKSEKDLAMIKEFAELLGAEFACTRPLIESGWVDAKRQIGLSGRTVRPRLIITCGISGAVQFSAGMNNSEHIFAINNDDKAPIFKVAHYGVVGNIYEIIPQLIEKIKMSKEA
>NZ_CP010520.1|WP_012449992.1|353524_354313_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNILVCIKQVPGTSKVEVDPVTGVLKRDGIDSKMNPYDLYALETALRIKENEGGNVKVLSMGPNQALSVIREAYSMGADEGALLSDRKFGGADVLATSYTISQGVRKMGDFELIICGKQTTDGDTAQVGPEMAEYLDIPHVANVERIIEIKEKSIIVEMDMPETLEVVEISYPCLITVDKGIFEPRLPSYRKKIATKDKEISIMSLNDFEDRNEKKYGLNGSPTQVERIFPPEVNDDREMWIGDSSELAEKIEHKLKEFKFI
>NZ_CP010520.1|WP_003372943.1|367696_368479_+|short-chain-enoyl-CoA-hydratase
MELKNVILEKEGHLAIVTINRPKALNALNSETLTDLDTVLENLENDSNIYAVILTGSGEKSFVAGADISEMKDLNEKQGREFGELGNKVFLRLENLDKPVIAAISGFALGGGCELSMACDIRIASEKAKFGQPEAGLGITPGFGGTQRLARIVGLGKAKEMIYTCDIIKAEEAYRIGLVNKVVSLESLMDEAKAMANKIIANAPIAVKLCKDAINRGMQVDIDKAVLIEAEDFGKCFSSEDQTEGMTAFLERREKNFQNK
>NZ_CP010520.1|WP_003371045.1|368559_369699_+|acyl-CoA-dehydrogenase
MNFQLTREQELVQQMVREFAENEVKPIAAEVDETERFPMENVEKMGKIGMMGIPFAKEFGGAGGDVLSYIMTVEELSKVCATTGVIVSAHTSLCASVINEHGTPDQKAKYLPELCQGKKIGAFGLTEPGAGTDAAGQQTTAVLDGDHYVLNGSKIFITNGGVAETFIIFAMTDKSQGTKGISAFIVEKSFPGFSIGKLEDKMGIRGSSTTELVMEDCIVPKENLIGKEGKGFGIAMKTLDGGRIGIAAQALGIAEGAFEEAVNYMKERKQFRRPLSAQQGLQWYIAEMDVKIEAARHLVYKAACKKQNGQPYSVDAARAKLFAAEVAMDVTTKAVQIFGGYGYTKDYPVERMMRDAKITEIYEGTSEVQKMVIAGSILR
>NZ_CP010520.1|WP_040968257.1|369716_370499_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNIVVCVKQVPDTTAVKIDPKTGTLIRDGVPSIMNPEDKHALEGALQLKETLGAKVTVISMGLPMAKATLREALCMGADEAILLTDRALGGADTLATSKALAGVIAKLDYDLVFAGRQAIDGDTAQVGPEIAEHLNIPQVTYVQGVEAKGEGTLLVNRALEDGYEKIEIKTPCLLTAIEELNEARYMNVANIFSTNDNEIKVMSAGDIDVDKAELGLKGSPTKVKKSMTKEVKGAGEVVNKPAKEAVTYVLGKLQEKHYI
>NZ_CP010520.1|WP_003373302.1|370521_371529_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MNIADYRGVWVFAEQREGELQKVSLELLGEGRKIADKLGVELTALLLGNNIENLSKTLAEHGADKVLVADDKNLEHYTTDAYTKVICDLANERKPGILFIGATFIGRDLGPRVAARLSTGLTADCTSLDVEVEDGALLATRPAFGGNLMATIACPEHRPQMATVRPGVFGKVNTDGSNCTVEKVEVKLADSDVRTKVVEIIKAHKDVVDISEAKILVAGGRGMGSKENFTLLQELAEVLDGTVAGSRAAVDNGWLERDYQVGQTGKTVRPSIYIACGISGAIQHVAGMQESDMIIAINKDETAPIMQVADYAIVGDVKKVLPELIAQAKAVKSAE
>NZ_CP010520.1|WP_003369662.1|371632_372481_+|3-hydroxybutyryl-CoA-dehydrogenase
MKKVFVLGAGTMGAGIVQAFAQHGYEVIVRDIKDEFVERGIAGINKGLTKQVAKGRMTEEVKEEILSRISGTTDMKLAADCDLVVEAAIENMKIKREIFAELDEICKPETILASNTSSLSITEVASATKRADKVIGMHFFNPAPVMKLVEIIRGMATSQETFDAIKELTVAIEKNPVEVAEAPGFVVNRILIPMINEGIGILAEGIASVEDIDTAMKYGANHPMGPLALGDLIGLDVCLAIMDVLYNETGDTKYRAHSLLRKYVRAGWLGRKSGKGFYDYSR
>NZ_CP010520.1|WP_012450991.1|372640_373075_+|hypothetical-protein
MLKETAIKYWDDKYDLNCAECLIYASNEEYDLNLSKDALKTMAAFGGGMAIGDVCGVISGAIAVIGIMFTDISGHKSPIVKKMTTEFINKFKNKLGSNNCIELRKEYRKSKKEGTCIVMVETAADILESIVNRDNNFKLDSNKY
>NZ_CP010520.1|WP_012451791.1|373164_374091_+|DNA-3-methyladenine-glycosylase-2-family-protein
MDYKSIETSENGVIIRGVKNFNLKHIFECGQIFRFEEIEDDNFIVIAFGKLIELVQKKDDVFIYNTTEKEFKEIWLNYFDLDRDYSIIKEELSKDELLKQSIEFGSGVRVLNQDPFEMLISFIISARNSIPSIRKTVNKISEQWGNKIEYKGKVYYAFPTIEQIKDAKLDEIKETGASFRSKYLIDTIENVHNSIGNKSNLSENEKELLNKYDLKYIKGLSDDECHAALQEFKGVGAKVADCIMLFSMGKTSAFPVDVWVKRAMMHFYNAEEGSLNKIRVFARNKFGKLSGFAQQYLFYYARENNIKV
>NZ_CP010520.1|WP_012449595.1|374252_375737_+|4Fe-4S-binding-protein
MFKFENQLIKLKHDVLSNIVRLAKEDNINKENLDKIPYEMLPGNEPQYRESVVHEREVLLERLKLASGFIPNGKGTDELVNIEDEKQILYVIKNACDMCPTKKFEVTDACRNCIAHKCQSVCNFGAITYVDGKAYIDPDKCKECGMCKKACPYDAIAEDMRPCKRSCPTGALDINSDKRAMIKQEKCVNCGACMAACPFGALEDRSLLVKIVKELTNNSNIYAVVAPAITGQLGPKTGYGQVKNAIKKLGFTDMVEAACGADAVTVHESNEFVERMENGDPYMTNSCCPGFLSYIEKMMPDQVDRISGTVSPMVAAGRFIKANDKDAKVVFIGPCTAKKSEILRDSIKDAVDYVLTFEELLALFEGFNIDPANFYDIVVDEASIFGRGFGVGGGLTAAIENYIKDKGIDCEFKPVKVSGGAEIKKTMMMAKMGRLPGNFIEGMMCEGGCINGSGKILSPMKAKSSFNKVNQQATMKNVLENSKIDDYKDIDLER
>NZ_CP010520.1|WP_012450317.1|375935_376631_+|response-regulator-transcription-factor
MKILLVDDEESILNLIKMNLIFENYEVITAECGIDAINLFKSESPDLIVLDLMLPDKDGFEVIHEFQSINSEVPIIILSARDQLNNKLLGLQLGADDYITKPFDSRELILRIRAISRRINKAKAIGKNEIKNKTNDIIEKGFIKIIVPERRVFIDDKEVIFTHIEFEIILLMVQNPFKVFTREELLDKIWGYSFVGNTRAVDIHIKRIRQKLIGNEDVIKTIYGVGYRLEV
>NZ_CP010520.1|WP_012450450.1|376634_378050_+|HAMP-domain-containing-histidine-kinase
MNWGIKGKIVIMNIFILIIAILSIYVVTIYTLYSRVINNSIDMLRKESYTSQSFIMKYLETEDDFHVENVLNEMSPFIATYLSNNCKFRVQIYNNSSLIGDSDNYPNISKDDDVVTALKGNKSYIIRRIEESSYILFSSPIYYSDGTIGCIRYVYDLNNENTIITNTILSMVLFAIVAIIFSSMMSNSFSNRIVRPIVSLKNIARKVSFGDFSKKISINSKDEIEDLSNSFNIMSNNIEIMIENLKDEKETQKRFLDNVTHEFKTPLAAILGYSDLLLRVKEKKDIEQCVKYIVQSSNRLLKLVEQLLDLSRLNKNELEVKNENVDIKSIIETAAMMLNPRMNKFGIKLNMNLISKSVYADKEKTEQVILNLLDNAIKYSECTEIDIYMENNEDYEIIYIIDNGQGIPKEDLKNVFENFYTAHKALQKKYGGSGLGLAICKEFMEKQSGKIEISSLNGTTVKLSFKHAISN

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Crispr_ID: NZ_CP010520_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010520_2

1657999-1658287

Orphan

II-B

Consensus_repeat	Method
GATTAACCTTAACATGGGATGTATTTAAAT	PILER-CR
GATTAACCTTAACATGGGATGTATTTAAAT	CRISPRCasFinder
GATTAACCTTAACATGGGATGTATTTAAAT	CRT

4 spacers

WYL

The CRISPR arrays of NZ_CP010520_2

>merge|NZ_CP010520|2|1657999-1658287|PILER-CR,CRISPRCasFinder,CRT
GATTAACCTTAACATGGGATGTATTTAAATTCATCACATACGTTAAATATATTTTTAACTACCTGATTAACCTTAACATGGGATGTATTTAAATACTTTAGTTCTAAATGTTTCGCTTGTTTTGTAGAAGATTAACCTTAACATGGGATGTATTTAAATGCTAATGAGATTCCAAGAGTTAACGATACATCTAAGATTAACCTTAACATGGGATGTATTTAAATACTTATTTGTATGCCTTTATTTGGGATTGTAGATTGATTAACCTTAACATGGGATGTATTTAAAT

>NZ_CP010520|2|1|1657999-1658287|PILER-CR
GATTAACCTTAACATGGGATGTATTTAAAT	TCATCACATACGTTAAATATATTTTTAACTACCT
GATTAACCTTAACATGGGATGTATTTAAAT	ACTTTAGTTCTAAATGTTTCGCTTGTTTTGTAGAA
GATTAACCTTAACATGGGATGTATTTAAAT	GCTAATGAGATTCCAAGAGTTAACGATACATCTAA
GATTAACCTTAACATGGGATGTATTTAAAT	ACTTATTTGTATGCCTTTATTTGGGATTGTAGATT
GATTAACCTTAACATGGGATGTATTTAAAT

>NZ_CP010520|2|2|1657999-1658287|CRISPRCasFinder
GATTAACCTTAACATGGGATGTATTTAAAT	TCATCACATACGTTAAATATATTTTTAACTACCT
GATTAACCTTAACATGGGATGTATTTAAAT	ACTTTAGTTCTAAATGTTTCGCTTGTTTTGTAGAA
GATTAACCTTAACATGGGATGTATTTAAAT	GCTAATGAGATTCCAAGAGTTAACGATACATCTAA
GATTAACCTTAACATGGGATGTATTTAAAT	ACTTATTTGTATGCCTTTATTTGGGATTGTAGATT
GATTAACCTTAACATGGGATGTATTTAAAT

>NZ_CP010520|2|1|1657999-1658287|CRT
GATTAACCTTAACATGGGATGTATTTAAAT	TCATCACATACGTTAAATATATTTTTAACTACCT
GATTAACCTTAACATGGGATGTATTTAAAT	ACTTTAGTTCTAAATGTTTCGCTTGTTTTGTAGAA
GATTAACCTTAACATGGGATGTATTTAAAT	GCTAATGAGATTCCAAGAGTTAACGATACATCTAA
GATTAACCTTAACATGGGATGTATTTAAAT	ACTTATTTGTATGCCTTTATTTGGGATTGTAGATT
GATTAACCTTAACATGGGATGTATTTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010520.1\|WP_012449875.1\|1650749_1652351_+\|alpha-glucosidase	unknown	unknown	gnl\|CDD\|200472
NZ_CP010520.1\|WP_012451653.1\|1654220_1655432_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340893
NZ_CP010520.1\|WP_012450395.1\|1667616_1668891_+\|peptidase-S41	unknown	unknown	gnl\|CDD\|143479
NZ_CP010520.1\|WP_012451898.1\|1668941_1670198_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012451714.1\|1649817_1650735_+\|DUF1861-family-protein	unknown	unknown	gnl\|CDD\|378102
NZ_CP010520.1\|WP_003373473.1\|1646744_1647572_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP010520.1\|WP_012450589.1\|1659144_1660107_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP010520.1\|WP_012451163.1\|1656311_1657076_+\|cell-wall-binding-protein	unknown	unknown	gnl\|CDD\|378179
NZ_CP010520.1\|WP_012449880.1\|1647585_1648674_+\|glycosidase	unknown	unknown	gnl\|CDD\|350124
NZ_CP010520.1\|WP_012422640.1\|1645821_1646718_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP010520.1\|WP_052457629.1\|1665523_1666492_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237050
NZ_CP010520.1\|WP_144311747.1\|1660920_1661625_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273806
NZ_CP010520.1\|WP_012450888.1\|1660207_1660834_+\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153234
NZ_CP010520.1\|WP_012449553.1\|1652528_1653464_+\|mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NZ_CP010520.1\|WP_040968287.1\|1663087_1664311_-\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|235010
NZ_CP010520.1\|WP_012450319.1\|1648742_1649804_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380629
NZ_CP010520.1\|WP_012451202.1\|1664300_1665521_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP010520.1\|WP_012449473.1\|1662288_1662741_+\|ASCH-domain-containing-protein	unknown	unknown	gnl\|CDD\|119345
NZ_CP010520.1\|WP_012449879.1\|1658458_1658866_+\|SMI1/KNR4-family-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012451525.1\|1653474_1654116_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851

Protein	Function_ID	Function_description	E-value
NZ_CP010520.1\|WP_012449875.1\|1650749_1652351_+\|alpha-glucosidase	gnl\|CDD\|200472	cd11333, AmyAc_SI_OligoGlu_DGase, Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins. The sucrose isomerases (SIs) Isomaltulose synthase (EC 5.4.99.11) and Trehalose synthase (EC 5.4.99.16) catalyze the isomerization of sucrose and maltose to produce isomaltulose and trehalulose, respectively. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomaltooligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. Dextran glucosidase (DGase, EC 3.2.1.70) hydrolyzes alpha-1,6-glucosidic linkages at the non-reducing end of panose, isomaltooligosaccharides and dextran to produce alpha-glucose.The common reaction chemistry of the alpha-amylase family enzymes is based on a two-step acid catalytic mechanism that requires two critical carboxylates: one acting as a general acid/base (Glu) and the other as a nucleophile (Asp). Both hydrolysis and transglycosylation proceed via the nucleophilic substitution reaction between the anomeric carbon, C1 and a nucleophile. Both enzymes contain the three catalytic residues (Asp, Glu and Asp) common to the alpha-amylase family as well as two histidine residues which are predicted to be critical to binding the glucose residue adjacent to the scissile bond in the substrates. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP010520.1\|WP_012451653.1\|1654220_1655432_+\|MFS-transporter	gnl\|CDD\|340893	cd17335, MFS_MFSD6, Major facilitator superfamily domain-containing protein 6. Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.48462e-17
NZ_CP010520.1\|WP_012450395.1\|1667616_1668891_+\|peptidase-S41	gnl\|CDD\|143479	cd07563, Peptidase_S41_IRBP, Interphotoreceptor retinoid-binding protein; serine protease family S41. Interphotoreceptor retinoid-binding protein (IRBP) is a homolog of the S41 protease, C-terminal processing peptidase (CTPase) family. It is thought to facilitate the compartmentalization of the visual cycle that requires poorly soluble and potentially toxic retinoids to cross the aqueous subretinal space between the photoreceptors and the retinal pigment epithelium (RPE). IRBP is secreted by photoreceptors into the interphotoreceptor matrix (IPM) where it is rapidly turned over by a combination of RPE and photoreceptor endocytosis. It is the most abundant soluble protein component of the IPM, consisting of homologous modules, each repeat structure arising through the duplication (as in teleost IRBP) or quadruplication (in tetrapods) of an ancient gene, arisen in the early evolution of the vertebrate eye. IRBP has been shown to promote the release of all-trans retinol from photoreceptors and facilitates its delivery to the RPE. Conversely, IRBP can promote the release of 11-cis-retinal from the RPE, prevent its isomerization in the subretinal space, and transfer it to photoreceptors. In vivo evidence implicates IRBP as a retinoid transporter in the visual cycle, suggesting a critical role for IRBP in cone function essential for human vision. IRBP is a dominant autoimmune antigen in the eye; IRBP proteolysis analysis has proven a useful biomarker for autoimmune uveitis (AU) disorders, a major cause of blindness. This family also includes a chlamydia-secreted protein, designated chlamydia protease-like activity factor (CPAF), known to degrade host proteins, enabling Chlamydia to evade host defenses and replicate.	4.1697e-11
NZ_CP010520.1\|WP_012451714.1\|1649817_1650735_+\|DUF1861-family-protein	gnl\|CDD\|378102	pfam08950, DUF1861, Protein of unknown function (DUF1861). This hypothetical protein, found in bacteria and in the eukaryote Leishmania, has no known function.	3.82338e-177
NZ_CP010520.1\|WP_003373473.1\|1646744_1647572_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	7.1594e-53
NZ_CP010520.1\|WP_012450589.1\|1659144_1660107_+\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.46324e-38
NZ_CP010520.1\|WP_012451163.1\|1656311_1657076_+\|cell-wall-binding-protein	gnl\|CDD\|378179	pfam09394, Inhibitor_I42, Chagasin family peptidase inhibitor I42. Chagasin is a cysteine peptidase inhibitor which forms a beta barrel structure.	4.3895e-23
NZ_CP010520.1\|WP_012449880.1\|1647585_1648674_+\|glycosidase	gnl\|CDD\|350124	cd18612, GH130_Lin0857-like, Glycoside hydrolase family 130 such as Listeria innocua beta-1,2-mannobiose phosphorylase. This subfamily contains the glycosyl hydrolase family 130 (GH130), as classified by the carbohydrate-active enzymes database (CAZY), enzymes that are phosphorylases and hydrolases for beta-mannosides, and includes Listeria innocua beta-1,2-mannobiose phosphorylase (Lin0857). hey possess 5-bladed beta-propeller domains similar to families 32, 43, 62, 68, 117 (GH32, GH43, GH62, GH68, GH117). GH130 enzymes are involved in the bacterial utilization of mannans or N-linked glycans. Structure of Lin0857 shows beta-1,2-mannotriose bound in a U-shape, interacting with a phosphate analog at both ends. Lin0857 has a unique dimer structure connected by a loop, with a significant open-close loop displacement observed for substrate entry. A long loop, which is exclusively present in Lin0857, covers the active site to limit the pocket size.	5.16458e-151
NZ_CP010520.1\|WP_012422640.1\|1645821_1646718_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	8.22611e-65
NZ_CP010520.1\|WP_052457629.1\|1665523_1666492_-\|hypothetical-protein	gnl\|CDD\|237050	PRK12305, thrS, threonyl-tRNA synthetase; Reviewed.	3.58249e-108
NZ_CP010520.1\|WP_144311747.1\|1660920_1661625_+\|hypothetical-protein	gnl\|CDD\|273806	TIGR01784, Uncharacterized_protein_pSLT051, conserved hypothetical protein (putative transposase or invertase). Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.	0.00210817
NZ_CP010520.1\|WP_012450888.1\|1660207_1660834_+\|glutamine-amidotransferase	gnl\|CDD\|153234	cd03140, GATase1_PfpI_3, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	2.46997e-76
NZ_CP010520.1\|WP_012449553.1\|1652528_1653464_+\|mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	1.29061e-79
NZ_CP010520.1\|WP_040968287.1\|1663087_1664311_-\|ATP-grasp-domain-containing-protein	gnl\|CDD\|235010	PRK02186, PRK02186, argininosuccinate lyase; Provisional.	6.04606e-36
NZ_CP010520.1\|WP_012450319.1\|1648742_1649804_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|380629	cd19974, PBP1_LacI-like, ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	8.90176e-96
NZ_CP010520.1\|WP_012451202.1\|1664300_1665521_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.02284e-49
NZ_CP010520.1\|WP_012449473.1\|1662288_1662741_+\|ASCH-domain-containing-protein	gnl\|CDD\|119345	cd06553, ASCH_Ef3133_like, ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation.	6.75558e-71
NZ_CP010520.1\|WP_012451525.1\|1653474_1654116_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.47219e-26

>NZ_CP010520.1|WP_012451163.1|1656311_1657076_+|cell-wall-binding-protein
MKKIKKVLVGILGIALSFSFMPKEANASWIKDNNGWWYSQQNYVIGWKQVNNIWYYFDNNGYMKTGWIHDNGRWYYTDLNGAMQTGIVEVNGKVYYLDKNGAMATGKVEINKQTYTFAMSGESIGNKIPQATKAFLSNGVEINPTKVNNTYVTSGKLVEIKLEGNPTTGYNWDYNINTNEVIKEESKDYKSDAAGLNIEGAGGIYTWKFLGIKEGTTKVVFKYSRPWENEVLETKTYIFTVDKDLNIIVEECNI
>NZ_CP010520.1|WP_012451653.1|1654220_1655432_+|MFS-transporter
MKNISFKLNTIRSFSMNLLFNSFGNSVVGTIYVLFLSQVKGFSDKDVSLMVGLIPIITIPSYILWGIIIDKTKKVVLTNKMVIIANIVTLILLIYVDNIYAFFIINLIRTVLLQPGGMVNDEYLLNLVKDNTGSYGSIRTFGTVGYGLGGLVCLLLMDYIEISGLLIIAIMSLASTLLFISKMPEINIDKSLKKGYHKTKFKIEQLDLLKNMKYMRLMIIYVLMNGTLASASSYAIPMIMIKLDAPQNIIGVMPFIMIVFELILLLQNKRLNFPEKRNKYLLIGLILLTIRWITMGVTESYVIIILISIIHGAVAGILLPIQNDMVEKFVPQNQQSTAIMLQTLLSSTIVPSILNIILGFLLEPWGIKSFGIVYLICNVITLFMYIINLLFNRYEEKRVVFDK
>NZ_CP010520.1|WP_012451525.1|1653474_1654116_+|ROK-family-protein
MKYYIGIDIGGTNLRAAILDEECNLVDKLKISNEVEEGPEYNLDKLILEIKERWSDKEIISVGVGCPGPLDIRSGTILVTPNLRTWEYFKLKEYLENKFDLPVFVNNDANVAGYSEAMVGAGKGAEKGNMELQKMLSEWVINVSKAIANIIVTVDPEVIVLGGSVIINNPSYLNKIKEETQKRVFDGIKINIKLAEIGDDTGLIGAGLLGKLK
>NZ_CP010520.1|WP_012449553.1|1652528_1653464_+|mannose-6-phosphate-isomerase
MYPIKFKNIYYEKIWGGRDLAQFRDNLPLGDIGESWDVACHSNSMSIVENGELKGKRFDELIKEYGKDLLGESFENKDFPLLVKLINSREKLSVQVHPNDEYANRVENSLGKTEAWYVVDAKPGACLIVGTKDCNKAVFEKAIKEGKTEDYLNKIQVKKGDCFLINSGLVHAICEGVIIAEIQQNSDITYRIYDYGRPREIHVDKSLDVIDFGLKAMNFSENKLDSYDGYKKGVLCSIEYFTMEKYVVNGEVEESSDINKFFIFTCVDGNGFIKSLHGHDIEVLKGDSILIPAKLGKYVIEGNLTLLKSYI
>NZ_CP010520.1|WP_012449875.1|1650749_1652351_+|alpha-glucosidase
MHKKWWKESVFYEIYMPSFKDGNNDGIGDFKGITSKLEYLSDLGIRGIWLTPFYPSPKVDNGYDISDYYNIDKDYGTLEDFNEFLSKAHSLGIKVIVDIVLNHTSSEHPWFKESRKSKDNEKRDFYIWKKEKPNNWESFFGGEAWEYDELTKEYYYHAFAKEQVDLNWSNPKVYEAMKDVLKYWIDLGVDGFRFDVINFLTIKNDLAQDNPYDEKGEQIHKYDKDQEGIIEIIKTLVKDIREIKEDVFLVGEVGSEDLNELKGYSGKDLLDVVFNFNLGSINEFSAEKIYKEIKNMNDNYDSYQIPTIFFNSHDMGRSISRFNPDGNKNGIEKAMAALLLTSYGVPFMYFGEEIGMKDLVCLDINKMNDIQGVTKYNIEISNGKTQEEALISANKSSRDKSRSPMQWNNSKFYGFSNTMPWINIEDKNDNELVEKQIKEEGSLINLYKDLIKIRYKNDTLLYGKYANLSFDDGVLIMERELNNETIRNVINFGDNEYIENNTEEIIYSNIKVQEKRTLGKFDFIIQRYKTTTN
>NZ_CP010520.1|WP_012451714.1|1649817_1650735_+|DUF1861-family-protein
MKDMKTCEILLAEYLKSESKIYGVEKINFINVGENDVYNISAPFVDNDKTIIAGRVEARDSEHSTVYFFEKNHEVWSPIDSYPTFSLQDPFFTKINNELIVGGVEIFPHPEIEGTLKWRTIFYKGKDVASLQRFFVGPDGMKDLRLVQLLDKRIGILTRPQGEKGGRGRIGFSIINTLEELNIKVIEDSPLLDGLFVDEEWGGANEARPLNETTLGILGHVACFDKDGNRHYYPMTFELNINTLEVKNQKLIAVRKDFKPGQAKRPDLEDVVFSGGLEIKEDKATLYAGISDAEAQFIIIDNPFK
>NZ_CP010520.1|WP_012450319.1|1648742_1649804_+|LacI-family-transcriptional-regulator
MGKVTMKDIAAKLNISINAVSLALNGKPGVSEETKKLVLDVAEKIGYLDRSPKFIQSFASKNICALIKQSHFEDSTFYSKILMSIVEEARKKGYDVITCIVNEDEQNIPSCIESKKVCGIIIISAIDDDYLIKLKEFELPVVLVDHASLLENTDSILTNNKLGSFKITKLLLDKGYTKIGFFGDLEYSLSIKERFFGYQEAIKKFIKFYNKDGITDFINNYSILSDLESYIINQDSEGIQKKISQMDNIPEAFVCSNDNAAIMLITSLKELGYEIPKDISVVGFDDIILSSLVMPKVTTVRVQKELMGKNAVNRLLWRIDHKDAPNEDIVMGVDIVERDSVGRKNIMENEQKN
>NZ_CP010520.1|WP_012449880.1|1647585_1648674_+|glycosidase
MNNKLNVVRSAKNPLIKPSDVKPSREDFKVDGVFNCGVCKYKDEYILLCRVAESVKVENEDEVKIPVVANENGKDVIKIISFNKKIDTEFDYSDSRSLWKLEKKGTRKIAYLTSLSHIRIARSKDGENFEIDDNAFIKPIASEEEWGIEDPRITQIDNKYYINYTSVTRNGAATSLVSTEDFKSYERHGIIFAPENKDVTIFPEKVNGKYLTFNRPVPCAIGAPDMWLAESPDLIHWGKQKHFYGGSDEESWDSGRVGGGAVPFLTEKGWLKIYHAADKEDRYCLGAFLLDKDDPMKILAKTNDPILEPEAVYEKDGFFGNVVFTCGCLFEDGIVKIYYGAADDKICRADIKIEDIFALMDK
>NZ_CP010520.1|WP_003373473.1|1646744_1647572_+|carbohydrate-ABC-transporter-permease
MKTKTKLKGIFVIVATMIILGISLFPYYYMIIQSFTPWDQIDKVMMPDSFTLKSYSYLFGGSGGATAGMWIKSLINSFIVSVPTAIISVVIGLLVGYSVSKMNKFKGEKFIMNTLLFQMFFPVIILLVPRYIISKPLTNTYLGMILPLSVSVWGIFMYINYFKSLPNEVFEAARIDGASELKILCSIGFPVAKSVTTIVFLSTFMTRWSELMWDMLISPKIDMQTLNVLISTQFKPMGNLPGPMYGASVILTIPIIIMFLCFSKHFKEGINFMLK
>NZ_CP010520.1|WP_012422640.1|1645821_1646718_+|sugar-ABC-transporter-permease
MKKKIDALKNSDGFLGWIFNVPYLAYSVVFFLIPLIWAFWLSTTDWNLMSNNKNFIGMDNFISLVNDPRVRAAFMNSFKYLVPIVLLTFAAAMIIALLVHKLPEKLKGITSVLFFIPYLTSGVAISVVVRYFFSYNSALNMFLREKGITIDWFRDPKWAFVIIIGIIVWKMSGYYALFILSALESISDDIHDACKIDGVKGIKKFIKVTLPMIIPTLTTVVVLTAGLAFGIFTEPYLLTGGGPNLATTTWQLEIYNTSFTNFQSGYGAAIAIASAVHIFITIKIITFTMGKVNKKYGM
>NZ_CP010520.1|WP_012449879.1|1658458_1658866_+|SMI1/KNR4-family-protein
MSKLTKYIEDLRKKYGDAIVTKESHYDDMMLLKVPEPLREFYREYESLEMPFGIIDSIEISIRSSEAEPFKSEGWFSFGADRYFSFWLCAYKEDNYGNSIISWDHDIDDEIEAMDNNIIDFLNDMKEEYEEYRKE
>NZ_CP010520.1|WP_012450589.1|1659144_1660107_+|WYL-domain-containing-protein
MPKNDNMLAILWMLNSGTKITAKQISERLEINIRSVYRYMDALCVSGVPIISESGHNGGYSLLNNFIRTPLFFDLEEKKSLLHAAIFAMEAGYPFMEALNSATSKLKMFSNQEQEKVLNRHLVGFEVVSRICDRAVKLILREIEQAVANECSIEIEYCTGYEGHPKHRVVDPYGMLYWNNKWYAIAFCHLRNEIRSFRVDRIVNIISTKNSFKRPEAFSAREFFTKNLLSNVESKVGLCTLVIEGKSEALNDLCAHWFLGYHLIERTECRANFLMDEDSIHTYVPHILLQYGKSIKVLEPNSFKDAMAAILRELMAHYLN
>NZ_CP010520.1|WP_012450888.1|1660207_1660834_+|glutamine-amidotransferase
MKNTVYLYVFDTMADWEIGYLSTEINSGRYYKKGLMPLKIVTVGITKTPITTMGGLKILPEIELKECSVKDTAALILPGGNTWTEAIHAPIIRMAEKYLEKGIVVGAICGATIGLAMGGVLNKRAHTSNDLGYLKMVCPSYDGEKYYKQECVVTDGSLITASGIAPLEFAFHILKILDVFLPQTLDSWYNLYKTQESKYFFELMNSIQ
>NZ_CP010520.1|WP_144311747.1|1660920_1661625_+|hypothetical-protein
MHVEVQSYSSDEAVFGERMFRYFYRIWDKFRYKYKDKSEIVAAAIYTYKGERGKDKKYVYKLPELEKEILTYNFKTIDVEKLSLENISEDNPLKLVFKMAKRLLETKQKDEDIYEAKINLAEELVNYDKVKNNEQIKALVDFLEYLFLIQNSEIEKKYDDYKKKKGGALKMTVDEIRRKHYTQKGKEEGREEGEKIKALEIAKNLLDILDNKTIAIKTGLTEEEIDALRKKEVN
>NZ_CP010520.1|WP_012449473.1|1662288_1662741_+|ASCH-domain-containing-protein
MTEMQMWNEYIKINTNAKEYQSWSFGGNTPKMPNLLAELVLKGIKTATASAYPCYISENAPLPPVGGYNLILNTKGEAICIIETTKVYTIPFNQVKEEHAYKEGEFDRTLISWRKCHSKFFSMELKEIGQEFTEDMLVVCEEFKVVYPKI
>NZ_CP010520.1|WP_040968287.1|1663087_1664311_-|ATP-grasp-domain-containing-protein
MLNKRILFIEPSFYGVNLVKAAKELYCEVVVIVSSDQNPIIYGYEGLYDDLLVCDIKSIDSIYKTIMKSKYYKNFDALIPGYDYVTAATAKVSELLDIKGTSYQATLTARNKDMARDIFLKNNVPSAKYAVITNYTDALKASNLIVLKPTNAAGSQNVSYIKDEDSLLKAFNKISKFKTSYLGFSVRQEYLIEEYLIGPEFSVELFLNEGSIEFAEITEKHTSDLPYFVERLHIFPSSICQEVRDNIIDVAKKAVFFIGIQNGPTHVEIKYTNEGPKIIEVNGRPGGDNITSDLIINSYGINIYKETIKMYLSEPLDMEKKNDIASAIGYILSEKKGKVKTITGLENLPNDKNVTRYQIDVKENYEVNISRSSEERLGYIIITAETSKEAKNKIEKLLKEIKITYFE
>NZ_CP010520.1|WP_012451202.1|1664300_1665521_-|MFS-transporter
MISILTNKNFRNFFVSDIISGFGVGLIMIAENWYVFTQTNSTKYVGFLLAFTVIASFIVSPIAGICADIFNRKNVISITYVVRISFLLVIALVFLMHGFDIRLMYLLSIINGIGWTFYMSTSRSFIQELLPKNLLIKGNSLLEICLQSGMLFSGAIFGIFFEYFGFVNILFINIIVFLISNFIVSRIQYNSIISTIDNEKFFKSFIAGLSYLRKRKVIFVFGIITIIPLAVTMIYNVVLPAYVNEISKNSSIVFGISDMFYGIGGLVSGFGVALIIKKMRNNQIIFLFFIIAISDLLSLYLNTNVFVLYFCSLLLGVSNSTLKIVMNTVLMENVDKQFMGRATAVWTAISLLIQAVGTSTMGIIIDNFGAKYGFLCMALLMFIGVISFVFIYSMINLIKKENSNVK
>NZ_CP010520.1|WP_052457629.1|1665523_1666492_-|hypothetical-protein
MYETTGHYNKYSKDMYPSFYAYDEDYVMRSVTCPNHYAIFLQQERSYKELPLRITEMSTLIRKDRSSELSGLYRTNTFTLNDAHIFCSQDNIELEFLKIIDFIKCVNDKFGISSHVRYRLSFSDFSNDKYIKNESLWKKSENILESILNKSDLDFFISKDKACFYGPKLDVLIENYNGKEYILTTVQLDFILPGKFNVYFINNNFEKEQPVVIHRALPFSIERTIAFLTEYYQGIFPFWLAPEQVVIIPTTLDNIKYSQQIEYHLKEIDIRIECDLRDTRFNKKIKQATLNRTPYIVIVGDKESKSNIYNSNLIFIQQKGVV
>NZ_CP010520.1|WP_012450395.1|1667616_1668891_+|peptidase-S41
MKFNKKGKVIATIVLVIAVVIGIFAFKIFHRVTNSPMIKSEDRNEKFITDIEFLKKELPKKHKNLFFSKSKEEFNDEIDSLINNVSRYSDEEINGELAKIIVSINDSHTNVDIMGSLAYPLSFFQFGDDIYLVDGDSEYKEYWGKKLVSINGYSIENLKEKLEPFISKDNEAISKNQFSVLLKCVEVLKLSGIVKEDNATFTFEGLSNADVMIKPVTMEEYMNIRTLSSDEEFKNRFPISKQNSNDNYWFKYIEEENTVYVKYNSCMEMKEYSFSDFTKDVFNVIDTKNATKLVVDLRDNGGGNSRIFEVFLDEIKKRENTNKVGNLYAIIGRRTFSSAVLNAMSLRNETNATLIGEPTGGKPNHFGEVKTIHLSNINIDVNYSSNYFKTSDEDTDSIYPNVEINLNAESFFNGQDDFLDYVIR
>NZ_CP010520.1|WP_012451898.1|1668941_1670198_+|hypothetical-protein
MLINKILEKFNKSSVTKIDNLIGEDILFKVKNGLGKLTMKFAKDINNDIKAIFYLGNTPLIMCNSEYCPTCSTMIALAKGRDEADDEVVKILSELNNIESLEDSFSKISPILSLLEDGYYVLKEVEFFPTDGEGNFFWNLKMKAKNYMASSYYYAPNYGTIIIEPKFLLPSQGTNSYNKDRVEYYRGKIRNGEKLFGLAIEMRGALGLLIDGHHKATACYLEGKPIRCITIINTFSYKNFNSKEEGISYTDNNIKYSDIKDGDSIKEFYEKKSKNRKSNISYKEVYLKEKYIKSIDIGIPKEEFPDYDTYALSTLASDTSEEKIRDLLNYIGENPLEELEEVFCNLRVNDKKRARELCFSILLLECFQNLWDECVMFLSRYNDEEVQEVFVNLLVEYGFEYGHNKMKHIIDEYFKRLI

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Crispr_ID: NZ_CP010520_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010520_3

1744755-1745511

Orphan

II-B

Consensus_repeat	Method
GATTAACATTAACATGGGATGTATTTAAAT	CRISPRCasFinder
GATTAACATTAACATGGGATGTATTTAAAT	CRT
GATTAACATTAACATGGGATGTATTTAAAT	PILER-CR

11 spacers

The CRISPR arrays of NZ_CP010520_3

>merge|NZ_CP010520|3|1744755-1745511|CRISPRCasFinder,CRT,PILER-CR
GATTAACATTAACATGATATGTATTTAAATGTGGCAACTCTTCCTCAATATTTGTTTTTGCTTCGAGATTAACATTAACATGATATGTATTTAAATTGTTGATTGATTTAGCGGACGAGTTGGGGGACGATAGATTAACATTAACATGGGATGTATTTAAATGCAGCGTGTGCTGGAATACTTAATGTAGCTGGAACAGGATTAACATTAACATGGGATGTATTTAAATTATAGAAGCTTTTAAAAATTCTACTAGTAAAGCTGTGATTAACATTAACATGGGATGTATTTAAATGAAGGTTTTAAATTATTTTCAAGTGCTTTACGATTGATTAACATTAACATGGGATGTATTTAAATTCAAACACTTGGAGTTTTTACAGATACTATAATAATGATTAACATTAACATGGGATGTATTTAAATTAAAGTTACTTCTTGTAAATTTAAGCAACATAAATACGATTAACATTAACATGGGATGTATTTAAATACAAGTCTATAAAGTAATAATTCTTTTGGTTTTCCTGATTAACATTAACATGGGATGTATTTAAATTCATATTGATTAATTCATTCCTGCTATACCCTGTTTGATTAACATTAACATGGGATGTATTTAAATTCTATAAAAGTTTCAAATTTAGACTCTATACCTCTGATTAACATTAACATGGGATGTATTTAAATATCCTAAGTATAGTAGTATAGTCCCCTCTCTAAACAGGATTAACATTAACATGGGATGTATTTAAAT

>NZ_CP010520|3|3|1744755-1745511|CRISPRCasFinder
GATTAACATTAACATGATATGTATTTAAAT	GTGGCAACTCTTCCTCAATATTTGTTTTTGCTTCGA
GATTAACATTAACATGATATGTATTTAAAT	TGTTGATTGATTTAGCGGACGAGTTGGGGGACGATA
GATTAACATTAACATGGGATGTATTTAAAT	GCAGCGTGTGCTGGAATACTTAATGTAGCTGGAACAG
GATTAACATTAACATGGGATGTATTTAAAT	TATAGAAGCTTTTAAAAATTCTACTAGTAAAGCTGT
GATTAACATTAACATGGGATGTATTTAAAT	GAAGGTTTTAAATTATTTTCAAGTGCTTTACGATT
GATTAACATTAACATGGGATGTATTTAAAT	TCAAACACTTGGAGTTTTTACAGATACTATAATAAT
GATTAACATTAACATGGGATGTATTTAAAT	TAAAGTTACTTCTTGTAAATTTAAGCAACATAAATAC
GATTAACATTAACATGGGATGTATTTAAAT	ACAAGTCTATAAAGTAATAATTCTTTTGGTTTTCCT
GATTAACATTAACATGGGATGTATTTAAAT	TCATATTGATTAATTCATTCCTGCTATACCCTGTTT
GATTAACATTAACATGGGATGTATTTAAAT	TCTATAAAAGTTTCAAATTTAGACTCTATACCTCT
GATTAACATTAACATGGGATGTATTTAAAT	ATCCTAAGTATAGTAGTATAGTCCCCTCTCTAAACAG
GATTAACATTAACATGGGATGTATTTAAAT

>NZ_CP010520|3|2|1744755-1745511|CRT
GATTAACATTAACATGATATGTATTTAAAT	GTGGCAACTCTTCCTCAATATTTGTTTTTGCTTCGA
GATTAACATTAACATGATATGTATTTAAAT	TGTTGATTGATTTAGCGGACGAGTTGGGGGACGATA
GATTAACATTAACATGGGATGTATTTAAAT	GCAGCGTGTGCTGGAATACTTAATGTAGCTGGAACAG
GATTAACATTAACATGGGATGTATTTAAAT	TATAGAAGCTTTTAAAAATTCTACTAGTAAAGCTGT
GATTAACATTAACATGGGATGTATTTAAAT	GAAGGTTTTAAATTATTTTCAAGTGCTTTACGATT
GATTAACATTAACATGGGATGTATTTAAAT	TCAAACACTTGGAGTTTTTACAGATACTATAATAAT
GATTAACATTAACATGGGATGTATTTAAAT	TAAAGTTACTTCTTGTAAATTTAAGCAACATAAATAC
GATTAACATTAACATGGGATGTATTTAAAT	ACAAGTCTATAAAGTAATAATTCTTTTGGTTTTCCT
GATTAACATTAACATGGGATGTATTTAAAT	TCATATTGATTAATTCATTCCTGCTATACCCTGTTT
GATTAACATTAACATGGGATGTATTTAAAT	TCTATAAAAGTTTCAAATTTAGACTCTATACCTCT
GATTAACATTAACATGGGATGTATTTAAAT	ATCCTAAGTATAGTAGTATAGTCCCCTCTCTAAACAG
GATTAACATTAACATGGGATGTATTTAAAT

>NZ_CP010520|3|2|1744887-1745511|PILER-CR
GATTAACATTAACATGGGATGTATTTAAAT	GCAGCGTGTGCTGGAATACTTAATGTAGCTGGAACAG
GATTAACATTAACATGGGATGTATTTAAAT	TATAGAAGCTTTTAAAAATTCTACTAGTAAAGCTGT
GATTAACATTAACATGGGATGTATTTAAAT	GAAGGTTTTAAATTATTTTCAAGTGCTTTACGATT
GATTAACATTAACATGGGATGTATTTAAAT	TCAAACACTTGGAGTTTTTACAGATACTATAATAAT
GATTAACATTAACATGGGATGTATTTAAAT	TAAAGTTACTTCTTGTAAATTTAAGCAACATAAATAC
GATTAACATTAACATGGGATGTATTTAAAT	ACAAGTCTATAAAGTAATAATTCTTTTGGTTTTCCT
GATTAACATTAACATGGGATGTATTTAAAT	TCATATTGATTAATTCATTCCTGCTATACCCTGTTT
GATTAACATTAACATGGGATGTATTTAAAT	TCTATAAAAGTTTCAAATTTAGACTCTATACCTCT
GATTAACATTAACATGGGATGTATTTAAAT	ATCCTAAGTATAGTAGTATAGTCCCCTCTCTAAACAG
GATTAACATTAACATGGGATGTATTTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010520.1\|WP_012449910.1\|1741145_1742018_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP010520.1\|WP_012450126.1\|1739776_1741027_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP010520.1\|WP_012451611.1\|1736446_1739050_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376899
NZ_CP010520.1\|WP_012451897.1\|1749665_1750856_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373059
NZ_CP010520.1\|WP_012451649.1\|1733898_1735584_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|372253
NZ_CP010520.1\|WP_012449946.1\|1754293_1755952_+\|hydroxylamine-reductase	unknown	unknown	gnl\|CDD\|235391
NZ_CP010520.1\|WP_012451518.1\|1743892_1744531_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012449424.1\|1739078_1739777_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP010520.1\|WP_012450496.1\|1746667_1747906_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341031
NZ_CP010520.1\|WP_003371960.1\|1743166_1743541_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|377953
NZ_CP010520.1\|WP_012449966.1\|1752756_1753251_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377935
NZ_CP010520.1\|WP_012450238.1\|1756245_1756899_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|319859
NZ_CP010520.1\|WP_012450284.1\|1745594_1746494_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP010520.1\|WP_012451345.1\|1753388_1754123_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP010520.1\|WP_012450056.1\|1751696_1752656_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012451066.1\|1748130_1749339_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|226925
NZ_CP010520.1\|WP_012450151.1\|1742227_1742878_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012451674.1\|1751069_1751534_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012450895.1\|1735766_1736444_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP010520.1\|WP_012450914.1\|1732951_1733884_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
NZ_CP010520.1\|WP_012449424.1\|1739078_1739777_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.69135e-78
NZ_CP010520.1\|WP_012451611.1\|1736446_1739050_+\|ABC-transporter-permease	gnl\|CDD\|376899	pfam02687, FtsX, FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Buchnera aphidicola LolC has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both LolC and Streptococcus cristatus TptD have been shown to require ATP. This region contains three transmembrane helices.	5.49658e-09
NZ_CP010520.1\|WP_012451897.1\|1749665_1750856_+\|hypothetical-protein	gnl\|CDD\|373059	pfam14424, Toxin-deaminase, The BURPS668_1122 family of deaminases. A member of the nucleic acid/nucleotide deaminase superfamily prototyped by Burkholderia BURPS668_1122. Members of this family are found as toxins in polymorphic toxin systems in a wide range of bacteria and in the eukaryote Perkinsus. Members of this family typically possess a DxE catalytic motif in Helix-2 of the core fold instead of the more common C[H]xE motif. The Perkinsus versions are predicted to be inactive.	1.39922e-47
NZ_CP010520.1\|WP_012451649.1\|1733898_1735584_+\|ABC-transporter-permease-subunit	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	7.10265e-15
NZ_CP010520.1\|WP_012449946.1\|1754293_1755952_+\|hydroxylamine-reductase	gnl\|CDD\|235391	PRK05290, PRK05290, hybrid cluster protein; Provisional.	0
NZ_CP010520.1\|WP_012450126.1\|1739776_1741027_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.04124e-43
NZ_CP010520.1\|WP_012450496.1\|1746667_1747906_+\|MFS-transporter	gnl\|CDD\|341031	cd17478, MFS_FsR, Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters. Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.21685e-102
NZ_CP010520.1\|WP_003371960.1\|1743166_1743541_-\|PH-domain-containing-protein	gnl\|CDD\|377953	pfam08000, bPH_1, Bacterial PH domain. This family contains many bacterial hypothetical proteins. The structures of Structure 3hsa and Structure 3dcx show similarities to the PH or pleckstrin homology domain. First evidence of PH-like domains in bacteria suggests role in cell envelope stress response.	1.42096e-45
NZ_CP010520.1\|WP_012450238.1\|1756245_1756899_+\|HAD-family-hydrolase	gnl\|CDD\|319859	cd16423, HAD_BPGM-like, uncharacterized subfamily of beta-phosphoglucomutase-like family, similar to uncharacterized Bacillus subtilis YhcW. This subfamily includes the uncharacterized Bacillus subtilis YhcW. It belongs to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), Saccharomyces cerevisiae phosphatases GPP1 and GPP2 that dephosphorylate DL-glycerol-3-phosphate and DOG1 and DOG2 that dephosphorylate 2-deoxyglucose-6-phosphate, and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.29075e-62
NZ_CP010520.1\|WP_012450284.1\|1745594_1746494_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.10713e-56
NZ_CP010520.1\|WP_012451345.1\|1753388_1754123_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.97141e-09
NZ_CP010520.1\|WP_012451066.1\|1748130_1749339_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|226925	COG4552, Eis, Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only].	9.39755e-52
NZ_CP010520.1\|WP_012449910.1\|1741145_1742018_-\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	5.45996e-15
NZ_CP010520.1\|WP_012449966.1\|1752756_1753251_-\|hypothetical-protein	gnl\|CDD\|377935	pfam07875, Coat_F, Coat F domain. The Coat F proteins, which contribute to the Bacillales spore coat. It occurs multiple times in the genomes it is found in.	1.37763e-17
NZ_CP010520.1\|WP_012450895.1\|1735766_1736444_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	9.09615e-111
NZ_CP010520.1\|WP_012450914.1\|1732951_1733884_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.17086e-95

>NZ_CP010520.1|WP_012451518.1|1743892_1744531_+|hypothetical-protein
MSLFLGKIHFWLFNKILWFEGLENEIIYVAKSEGLDILNLQKEIEDKYGGKLPNKPLDEIIDTSNIHGWLQEKIYSSEGRIAAWTTIIIDNRREAKEKLEEIYTNQGIMAAKEVNEKGFILDSAEDIFNKVNDYILDGMPCDRVNEIINSNENCVKWTRRICVHKEIWDKESGDVEYFYFLRSLWIKAFVNEINTEFDYLEDSKGVKSIRRK
>NZ_CP010520.1|WP_003371960.1|1743166_1743541_-|PH-domain-containing-protein
MIDFNNGALFKLKKTSNDDISKQIEPLLISGEIIISTYKTIRDYVVFTSKRVIAINVQGITGAKKDYTSLPYSKIQAYSIETAGTFDLDSELEMYFSGLGKVKFDFKGSSDIIKIGQIISEFVL
>NZ_CP010520.1|WP_012450151.1|1742227_1742878_+|hypothetical-protein
MNDAYVFKDDNRYGEYCDTVNIGDINVNFKPTEFIEKFIKSSYNIKKVNLNYTVLIGTYNLEDGKKIDYYYKPYITLEKDSEKNYENSVQKISMADMKKASEEAQIRRYDFIADYTYTRSKSNKRRSVVECEENPLLVKIIDNVIYNYERKFMRELNIISFESFFNKIVQEGEIEVKNIYNTYVKIHNTSYYKEKFKKIPSFKISKIGMEYFYSKY
>NZ_CP010520.1|WP_012449910.1|1741145_1742018_-|DMT-family-transporter
MNTYKGISYAILSSVAFGLMPIFASIAYENGSNPTTVIIFRFLLSSISLFIYLLYKKVKIKIERKPMLILLGIGIIAYTVTTQTLFISYNYLGAGLATTLHFIYPAIVCIIGFVFLKEKISKRKLISLLLSGIGVYSLVAFESKSLSAIGIFLALFSGVAYAINLIILGLDCIKSIDNKISTLYMCVGATLGMITYGLFTKSIVLTFNTKMVASYIGISLISTIVSIILLLKAIELIGTSSTSILGTFEPIISIIFGVLILGENLSFELVIGAALILTATIVLAKDTKSE
>NZ_CP010520.1|WP_012450126.1|1739776_1741027_+|HAMP-domain-containing-histidine-kinase
MITLYYKDERVKLSLFILSVFIIQGIIFGVIYFNSILAINKDVITQNSSIIGELYLKDKELALEIIPIITGKKLNNVEIGEKILSDYSYNTALKYNNNPVIGNVTQSTVLLFEILILVTFLILIIGSFIIMNPLYNEIKYLTHRAESIVENKIIHNDKQYSYRGSLDKFILKFNLMEDRIKNSIGLLQEEKINLKNIINDISHQLKTPLTALSMYNDIISDHREMNNEDLDNFINLSKDQLERMEWLVKTLLKYARLESNVVEYNKEMFSIKNTIEESINPLKVKAKNKNQSLILKCEKDIEYYHDRKWVSEAISNIVKNAIEHTENNGKIEINLYETPITITISIKDNGEGIEKEELKKIFNRFYKGETSINPTSIGIGLCLSKSIIKAHDGDITVESYLGKGSIFYITFLKTVL
>NZ_CP010520.1|WP_012449424.1|1739078_1739777_+|response-regulator-transcription-factor
MGNILLVEDDRAVALAVIYSLKKEHFNVEHAINLRSAKNMITDDIDIILLDLMLPDGDGYELCTEIRQSGNDVPIIFMTACDEESNVVLGLDLGADDYVTKPVKMRELISRINAVLRRKGKNKVFEERKIIESEGILLDKGAHLVKKDGNEISLTLNEFKLLQFLMENSPNVLTRNTILEKLWDIEGNYIDANALSVYIKRLREKVEYDSRTPTLIETVRGVGYKWTPKVVK
>NZ_CP010520.1|WP_012451611.1|1736446_1739050_+|ABC-transporter-permease
MKAYSYLANKQFKVNKKRNFSIVLGIILSIILFTTVGYIQSFAREIDIINAKEERGNYEAIFKNISKEDVYTLKNNVLIRTVGIYKKETEDKVKIGSLDKTIEVYALDSESIHNLFKPLIKIIKGRYPVSENEIILNQSVNLELNKYIDDKITIGDKSYVIVGFCDNEKYSNPYVINGITYLEKELFDGDINVAIISKDIKNKLVEIKNIANRIGISMEEVNEERGIIFNKRLFDSYGISVDENTNYIDEYKMGSISLYGIILILSTILTYSSINVSVKERIQQFSSLRCIGATPSKIRILLMKESFLLIVFSLIPGIILGQIVCFIISGVIFNKIIGINTYGILYKVYWNVILTVILLSILNIIISTMIPIIKMGHISPIQGAKTGGEIKSSIKRGNYKIIKKLFGYNAELAYKNIRIGNKNFIITTSALSILLIIFITFTGYYNIIINNYRSERNKNKDVSMTVYRSIPNEFNSLNSLDMLNKHKSDVKHLEVTDEINAHINYSIKALFKDVNLNKWIKTVDSKSNYGESIIYNNGKKYVYSNSVSLLIYDNESINEILPYIEDDINNKNNIKLEDFKENGVIVAYRSILKNGFNPKKEEIFDLNIGENFIMYIDSSNINESVYGKDTNYIDNMKEYINMKFLGSIDGDDLFEGNRHGFSNHLTIIASEDFYDNNKEILSSNNYNVNMEINLKKDLDRELSKDTIGSYANKIGEFYLDNESTFQDSRKSFLALSSIIYTVLFLTIFIGGVTILNNKNISILLRKKELGILLAIGINKKRLKKVLLFEGIIQWFISSSIGILSSYIILRVIYSVLYYSGEADNFRMPIISVLIVISILFIIILLGSYFPVRKLNQMETTELIRNEE
>NZ_CP010520.1|WP_012450895.1|1735766_1736444_+|ABC-transporter-ATP-binding-protein
MNVIRLNGVYKSYGNGENEVKALKNINLDIKKGEFVSIIGASGSGKSTLLHILGGIDRPTEGEIFIEDVNLKNLSENEISLLRLRKVGFVFQFYNLIPVLTVEENIEMPVLLDDGAIDKDYKNELIKLLGLENKLNNLPSELSGGQQQRVAIGRALANRPSIILADEPTGNLDSKTAMDIMELLKYSRKKYNQTLILITHDERIAKMADRVIGIKDGEIAINEVI
>NZ_CP010520.1|WP_012451649.1|1733898_1735584_+|ABC-transporter-permease-subunit
MKLFNLTYNEVVKQFKKTSIKIIIPIILLSAIVLPLGISKINVDSNIKNAMESNLFLLEDVNNSIESLNKDKNQKAQIEKAYLQAEKEYRQLFVDYKIGFDDWKQKEAEEFRYIAYNLVAIELVLNGYRQDVVLESLQGVNPDEVIKYYEMTLENKKEVEIKFIAEKEKLKDIIINNDYMGHTALEIERKEKYIEGNKKIIYEYEKLKAKNPNDEEGKEKLEELKKENNLAIKEIYALEQDLQVLRFRYDKKVDYDKNNWKNNSIKSIEKNLEEFRRTMQTEKEFSSMANQQRIEITYDEYVKNYETQNDKCIEEIKELWYGLENEIPPLNSIRDARSVIDGTYEFYVIFAVIIAIIIGGGIVANEFSKGTIRLLLIRPVSRWKVLLSKLLSVLIISFGIVILGTTILVISSGYVYGFETLKTPLLETINGTITKIDYIQYMIPKLMISVSSLIFITSLVFMISTVARNTALAVAISMVLYLGAAPLTQVLINMKQVWLLKTLIPYINGSFFKIMPFFTEQLSKEYGIQMQYTIGAKQLLLASILMIIVTFVTFTKKDIKN
>NZ_CP010520.1|WP_012450914.1|1732951_1733884_+|ABC-transporter-ATP-binding-protein
MKAVLELKNVSKVMGNTALVEDISFTVNKGEIFGFLGPNGAGKTTTIKMITGLYSISKGEIYIDGKNVKKQFEKALKGVGGIIENPEMYGYLSGKDNLKIYARMHGGITKHRIDEVVNLVKLGNRINDKVSKYSLGMRQRLGVAQALLHRPKLLILDEPTNGLDPMGIKELRETLRELCDKEGLSVMVSSHLLSEMELMCDRFGIIDSGKIIDIKTIDDIKNNESLNIKTYLLEVNDKKKTIRIINSRYPNVVLNEDKEGIKISCEKDELAKINKELVINDISVFGTRVITKTLEDEFMEVTSGSKDQIR
>NZ_CP010520.1|WP_012450284.1|1745594_1746494_-|LysR-family-transcriptional-regulator
MDIRQLRYFLTIAEEGHITAAAKKLNISQPPLSKQLKLLEEELGVTLFNRTSRNLELTDAGILLQNKSSQLLELYKSTINEMKNFNNGIEGTLGIGTVCSSGINVLPQKIKEFCKQYPKIDYEIYEGNSFKIMELLNNGVIDVGFVREPFNLSLYNSFIIKDNLENNLNDYFVTIAKSKFYNSIESNTILINELKDKPLIINRRYDDVIKNACNKAGFEPHIICKNDDIITSLSWAEAGIGISILPLTASNILPNVNLKIKKIIEPSIESYLRLIWPKNKPLSNISCNFIEMFDKNIFN
>NZ_CP010520.1|WP_012450496.1|1746667_1747906_+|MFS-transporter
MNKKFIRLFAAGHLVTDIYQGALPAMLPFLISEKNLSYAAAAFLIFAANASSSIIQPLFGIYADKISLPWALGTGVLLGGIGIGVSGVTSSYNMIFSLVALSGVGIALYHPEGARLTNKFSGENKTTGVSQFAAGGNIGFAVGPIITTVILSILGLKGTILLCIPAIIMGLILLYEARYFSKNENELVNERECIRNKGEVKADQWGAFGRLTLTLLCRSTVFFGLNTFLALYFVHVLNQSEVHGSIALSTLIVVGAVGTLFSGKLADKSGNKKVIILGYSCLVPLLICFLSIKNPIIVTIILIPLGFFLYMPYSPMIALGQKYLPNHVGLASGVTMGLGVTMGGVVSPILGWVSDNYGIHTALCTLIAMPIFAVILARKLPVCNEELENDKMQENVQSNTKKLSNKSLNLQK
>NZ_CP010520.1|WP_012451066.1|1748130_1749339_+|GNAT-family-N-acetyltransferase
MNKKQLKLKSIGIEHLEQYNQLLRYVFQVTEHELNQIGWQDKEIIRAKSPTLKQADVLGWFDGDNVISQVAVYPMKVRIFNCTYDMGGLTGVGTYPEYSNQGLMHKLLYQALYNMKERKQFISYLYPYSIPYYRRKGWEIISDKITYEIQDYQLPKNRQVAGDVRRVPIESDQVKKAYNRFAYLTHGALLRDDLAWNEYWLWDTDDIMAAVYYNENDEPDGYVIYWIADDVFHIKDMIFVNEDARIGLWNFVSAHFSMISKVVGNTFTDEPLAFLLEDADIKETISPYFMARIVDFEHFIEEYPFKPDTIEREWRFTLSDPLLAWNQGTFTLKISNDGKGKVVHSTEKTTDRIDIQTMTTMLLGYKRPDYLHRIGRIVCSSMTVDMLEDAIEQQSPYFSDYF
>NZ_CP010520.1|WP_012451897.1|1749665_1750856_+|hypothetical-protein
MQEKEVLNSLRCNTQSIEEEIQINVLLNKTKRNRIKINNLDEFKDALKKEGYEINEFDEEKFKEDLVKIFQVDSSVIEVLHTYINNPEITYKVYDASDLIDYIKKMILFENEYNRLCEKISSIKKMDIDRVEYEREFSLQDNVEDIIRAIEEIKDDISGIISKEGKTRLENLEREINKEYLYAKDIELLKKMVIIENENVKEEYNIESKIKTISIEIPKKINYEHIVAKKGSVEYHDYLSSNIPRMQRLIKNMHKYMKVDEKEKSTFKINQSKALQDSINIAVATYDNKEFKAISGSNDIKNYCKITPIENATFKSSKVNKLGNLGIGYNRVNDSEKKIFEEIHRQIEKNALKDEGNLILYTKLEPCPSCYYVISQFCKKYPNIKVQVKYSKKYGE
>NZ_CP010520.1|WP_012451674.1|1751069_1751534_+|hypothetical-protein
MRGKHAIGNRPFGNIHLDYIRYKESDKDIRQMYERVKNDYLKNENLDIDLEKAYLNERFISYKGDIGKYYLNVFIISLTAFLGGIFTQYFNRSFMTLAILIAFIIIVVKFFSNIHTKIMFNKEKYEHKYYIICIEALKEIEHEQNSIIELENIN
>NZ_CP010520.1|WP_012450056.1|1751696_1752656_+|hypothetical-protein
MKNKRYLISLIFVIVMIVMAEFTGEKEIIFPEVLSLAVGAWISDKQPWKINKIGLVALMTLSSTFGTCIVRYFSFPLIIKFMIALIFIGLILKLTQTTLVPTISAAILPILLNTETWIYPISVCIMSVIIVLVQYGMEKYGLRECENKQVEETEISKNQRKLETIRLSKIFLVTTILAALAFTSKNMFIIAPPLIVGFIELSNVQSKARNNNKKIFMLFVFASIIGMVSRVFISEYLSLPLWVAGSIATIGIFICFEKLKVTFAPVAAIALLPMLLDIEKVKYFPIQVTLGSIVLIFLAMTIFKEETMEVSSMSTSINS
>NZ_CP010520.1|WP_012449966.1|1752756_1753251_-|hypothetical-protein
MVNLSMKERILLQDEKSHEELCVEKYNKYSNKACDVELKNLFSTLAQKEQQHLDSINQMLSGTVPNVNQGQQANQNQNANQNQTSMQNMNNTANSQLTQNDISNDKMLCQDSLSTEKYVSSTYNTAIFEFKDKNMRQVLNHIQKEEQEHGEQIYNYMSQHGMYN
>NZ_CP010520.1|WP_012451345.1|1753388_1754123_+|hypothetical-protein
MKENLKDKIDNFLNENKINITGGTIKTEEELSLVLNNIAMSDLKKGKFQKSLYFVSKALEFDSKNYYALFIKGLIYRYSKNFNKAIKTFEEYYDLSKDSLSLIHMGFCYAELNDSDNALEFFRKGEQEFTEDEKNKYSSLMYTVYECMGNIYMNRENILEFKENDKFSLNYKLAIKYYKMSLRINKNNHLLLNKLAACYHHFDDEKKALYCYEEAAKVAPEIQEYKGAIEEMKEQGIIADVIEF
>NZ_CP010520.1|WP_012449946.1|1754293_1755952_+|hydroxylamine-reductase
MEQNPMFCYQCEQTAGGKGCTKLGVCGKTPEVANLQDLLIYQCKGISVYAMELIEKGENIDKDIVKFVENSLFTTLTNVNFDAEVHVEMLKESQKIKEELRKKIVNNKEYPEQASYNLSETKDEMLKDSKKAGIMFDQTIDADVRSLRQTIIYGLKGISAYGHQARFLGYYDDQVDNFYFRGLECTTNDNLSVEELIRMTMRTGDMSVAVMKKLDEANTETYKNPIPHKVNVHIKKGPFIIVSGHDLRDLEMLLKQTEGKGINIYTHGEMIPSHGYPGLKKYKHLVGNYGGAWQDQQKEFDGIPGCILMTTNCLMRPRETYKDRIFTTSVVGWDGLKYIKADKDGYKDFTEIIEKALELGGFKESEEPHEILVGFGHHATLSNAETIVNAVKDGEVRHFFLIGGCDGARPGRNYYTEFAKKVPMDCIILTLACGKYRFNKLEFGEVAGLPRLLDVGQCNDAYSAVRIATALADAFDTDVNGLPLSIILSWYEQKAVADLLALLSLGIKGIFVGPTLPAFFSPNVLQYLVDTFNLKLISEPDDDLKTCLQQGV
>NZ_CP010520.1|WP_012450238.1|1756245_1756899_+|HAD-family-hydrolase
MRAFIFDMDGVIIDSEPIHRQVHGEIMNTLGINISKGELALYAGATNEYIFTKLKERYGIKKSVSELMDYKSKLIINKVKEESLEPINGIRELLNALRKNNIKIAIGSSSPRSLIEAVIDKFNLHSAFDCIVSGEEVERSKPYPDVYIEVSKNLGINPEKCIVVEDSHNGVQAAKSAGMKCIGFNNVNSGNQDLSKADVRVDTIRKIDIYNLCKYFE

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Crispr_ID: NZ_CP010520_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010520_4

2216760-2216882

Orphan

Consensus_repeat	Method
GTAACTGCTGCTACTACTGCT	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP010520_4

>merge|NZ_CP010520|4|2216760-2216882|PILER-CR
GTAACTGCTGCTACTACTGCTTCAAGTGGTTCACCTACTCAAGCACAAATTGATGCATCTAAAGCTGCTATTGCTGATCTAAAACTTGCTACTGCTGCTTTAGTAACTGCTGCTACTACTGCT

>NZ_CP010520|4|3|2216760-2216882|PILER-CR
GTAACTGCTGCTACTACTGCT	TCAAGTGGTTCACCTACTCAAGCACAAATTGATGCATCTAAA
GCTGCTATTGCTGATCTAAAA	CTTGCTACTGCTGCTTTAGTAACTGCTGCTAC
TACTGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010520.1\|WP_040968314.1\|2208223_2209342_-\|anti-sigma-factor-domain-containing-protein	unknown	unknown	gnl\|CDD\|378948
NZ_CP010520.1\|WP_012450009.1\|2205862_2207134_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|236967
NZ_CP010520.1\|WP_012451911.1\|2211616_2212894_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275079
NZ_CP010520.1\|WP_012450666.1\|2223506_2225945_-\|DNA-helicase-RecQ	unknown	unknown	gnl\|CDD\|273594
NZ_CP010520.1\|WP_012449593.1\|2218174_2219224_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012451090.1\|2203924_2204386_-\|DUF1097-domain-containing-protein	unknown	unknown	gnl\|CDD\|368942
NZ_CP010520.1\|WP_012450358.1\|2217294_2217903_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237177
NZ_CP010520.1\|WP_012451062.1\|2227197_2227464_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239065
NZ_CP010520.1\|WP_012451478.1\|2210377_2211430_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012450578.1\|2199951_2201034_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|225176
NZ_CP010520.1\|WP_012450492.1\|2227506_2227758_-\|holin	unknown	unknown	gnl\|CDD\|379763
NZ_CP010520.1\|WP_012449590.1\|2219438_2222591_-\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|350770
NZ_CP010520.1\|WP_012450795.1\|2209351_2210014_-\|RNA-polymerase-sigma-factor-SigI	unknown	unknown	gnl\|CDD\|236233
NZ_CP010520.1\|WP_040968315.1\|2229903_2233419_-\|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase	unknown	unknown	gnl\|CDD\|131231
NZ_CP010520.1\|WP_012451722.1\|2204624_2205863_-\|NAD-dependent-dihydropyrimidine-dehydrogenase-subunit-PreA	unknown	unknown	gnl\|CDD\|236237
NZ_CP010520.1\|WP_012451487.1\|2201487_2202036_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP010520.1\|WP_012451473.1\|2228466_2229519_-\|serine-protease	unknown	unknown	gnl\|CDD\|349398
NZ_CP010520.1\|WP_012449484.1\|2202303_2203626_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|182613
NZ_CP010520.1\|WP_012451406.1\|2222797_2223316_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|172773
NZ_CP010520.1\|WP_012450102.1\|2226343_2227141_-\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|119385

Protein	Function_ID	Function_description	E-value
NZ_CP010520.1\|WP_040968314.1\|2208223_2209342_-\|anti-sigma-factor-domain-containing-protein	gnl\|CDD\|378948	pfam12791, RsgI_N, Anti-sigma factor N-terminus. The heat shock genes in B. subtilis can be classified into several groups according to their regulation, and the sigma gene, sigI, of Bacillus subtilis belongs to the group IV heat-shock response genes and has many orthologues in the bacterial phylum Firmicutes. Regulation of sigma factor I is carried out by RsgI from the same operon, and this N-terminal cytoplasmic portion of RsgI ('upstream' of the single transmembrane helix) has been shown to interact directly with Sigma-I.	2.14194e-07
NZ_CP010520.1\|WP_012450009.1\|2205862_2207134_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|236967	PRK11749, PRK11749, dihydropyrimidine dehydrogenase subunit A; Provisional.	8.25491e-156
NZ_CP010520.1\|WP_012451911.1\|2211616_2212894_+\|hypothetical-protein	gnl\|CDD\|275079	TIGR04247, nitrous_oxide_maturation_protein_NosD, nitrous oxide reductase family maturation protein NosD. Members of this family include NosD, a repetitive periplasmic protein required for the maturation of the copper-containing enzyme nitrous-oxide reductase. NosD appears to be part of a complex with NosF (an ABC transporter family ATP-binding protein) and NosY (a six-helix transmembrane protein in the ABC-2 permease family). However, NosDFY-like complexes appear to occur also in species whose copper requiring enzymes are something other than nitrous-oxide reductase.	0.00171066
NZ_CP010520.1\|WP_012451473.1\|2228466_2229519_-\|serine-protease	gnl\|CDD\|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	9.18795e-37
NZ_CP010520.1\|WP_012450666.1\|2223506_2225945_-\|DNA-helicase-RecQ	gnl\|CDD\|273594	TIGR01389, recQ, ATP-dependent DNA helicase RecQ. The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP010520.1\|WP_012451090.1\|2203924_2204386_-\|DUF1097-domain-containing-protein	gnl\|CDD\|368942	pfam06496, DUF1097, Protein of unknown function (DUF1097). This family consists of several bacterial putative membrane proteins.	1.14415e-25
NZ_CP010520.1\|WP_012450358.1\|2217294_2217903_-\|hypothetical-protein	gnl\|CDD\|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	2.71932e-06
NZ_CP010520.1\|WP_012451062.1\|2227197_2227464_-\|hypothetical-protein	gnl\|CDD\|239065	cd02152, OAT, Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in the arginine biosynthetic pathway. Members of this family may experience feedback inhibition by L-arginine. The active enzyme is a heterotetramer of two alpha and two beta chains, where the alpha and beta chains are the result of autocatalytic cleavage. OATs found in the clavulanic acid biosynthesis gene cluster catalyze the fifth step only, and may utilize acetyl acceptors other than glutamate.	0.0022507
NZ_CP010520.1\|WP_012451406.1\|2222797_2223316_-\|molecular-chaperone-DnaJ	gnl\|CDD\|172773	PRK14285, PRK14285, chaperone protein DnaJ; Provisional.	9.64756e-06
NZ_CP010520.1\|WP_012450578.1\|2199951_2201034_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	4.48679e-49
NZ_CP010520.1\|WP_012450492.1\|2227506_2227758_-\|holin	gnl\|CDD\|379763	pfam16079, Phage_holin_5_2, Phage holin family Hol44, in holin superfamily V. Phage_holin_V_2 is a family of small hydrophobic proteins with three transmembrane domains of the Hol44 family. These proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion. Full activity of the endolysin Lys44 from oenophage fOg44 requires sudden ion-nonspecific dissipation of the proton motive force, undertaken by the fOg44 holin during phage-infection.	6.38764e-16
NZ_CP010520.1\|WP_012449590.1\|2219438_2222591_-\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|350770	cd18012, DEXQc_arch_SWI2_SNF2, DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins. Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	1.59054e-101
NZ_CP010520.1\|WP_012450795.1\|2209351_2210014_-\|RNA-polymerase-sigma-factor-SigI	gnl\|CDD\|236233	PRK08311, PRK08311, RNA polymerase sigma factor SigI.	3.73983e-81
NZ_CP010520.1\|WP_040968315.1\|2229903_2233419_-\|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase	gnl\|CDD\|131231	TIGR02176, pyruvate_flavodoxin/ferrodoxin_oxidoreductase, pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric. This model represents a single chain form of pyruvate:ferredoxin (or flavodoxin) oxidoreductase. This enzyme may transfer electrons to nitrogenase in nitrogen-fixing species. Portions of this protein are homologous to gamma subunit of the four subunit pyruvate:ferredoxin (flavodoxin) oxidoreductase.	0
NZ_CP010520.1\|WP_012451722.1\|2204624_2205863_-\|NAD-dependent-dihydropyrimidine-dehydrogenase-subunit-PreA	gnl\|CDD\|236237	PRK08318, PRK08318, NAD-dependent dihydropyrimidine dehydrogenase subunit PreA.	0
NZ_CP010520.1\|WP_012451487.1\|2201487_2202036_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.6682e-11
NZ_CP010520.1\|WP_012449484.1\|2202303_2203626_-\|amino-acid-permease	gnl\|CDD\|182613	PRK10644, PRK10644, arginine/agmatine antiporter.	4.32832e-80
NZ_CP010520.1\|WP_012450102.1\|2226343_2227141_-\|glycoside-hydrolase	gnl\|CDD\|119385	cd06525, GH25_Lyc-like, Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.	6.98653e-100

>NZ_CP010520.1|WP_012451911.1|2211616_2212894_+|hypothetical-protein
MIQNSTDLIKHINIEETISLTPEIYALKSPLIIGNTFEILGNGSTLVGPILICTDIIISDITFSNTDNIIRLTSDCSVVFKNCTFLGNNKNSAIILENHSKSTLSLKNCIFHNFFSAISVNEDNTLDLLQDCLFEFCNVAINNVVKNSIINIHSINNNLMFNSKESIFLNFSESFNIEDYHNFCFELSSRNSFARILGKSSTTVFDTSCFYIDNLKNLSVILKSCPHCSTIFLKEGQYNLTSSLLDDELTIDVPINLIGINSPKLYKSENDFIKYAIIINTSNVRIKNIVIDGGDKYSLRDGIHFEENGATNIKIQNVTISRILRRGVSIWGKKTSNCIIDNCKFSYIKEQCAIYASGTTYIYNSNFKNLRTAINCINKNVILFENNLFENIYCCLLNEIIPFNNIKQKNNTFNFVENLVMLSKY
>NZ_CP010520.1|WP_012451478.1|2210377_2211430_-|hypothetical-protein
MAKVNYINQASFYDQNTDCLKITEAPIIIKAETKVFSYKYVFSEADCNCSENCYPGKGDDVGFTLIFGNYGEETYTPTSTTDPTVIDTLDLSNIYNASLKVMDLCIGKNFKVFDITGVTPGSGQGTEVIHGETEFIGGSVYTLEIRECYENPETGEKCTAAFCLPCHSVFCITMLFQVEFTPCSKLKNGGFCNGTTPSLENWIAIPATGGGTVQAVASYTSSTNVNVTPKDGDCGFALLKTGANEVKSILKQTFEVKAGDVLSFYAFFDLMDIPGWPDEAQVIVIKNSSGNVIDTIVTKNAHYVSTDWEYYSYNVEECGTITFEASVKNVREPILPDGYLAIDAVTITHP
>NZ_CP010520.1|WP_012450795.1|2209351_2210014_-|RNA-polymerase-sigma-factor-SigI
MLECVLEDLNIGQDLDVNQLIEKHMPFIIKSISDVTGKYVSCENDEELSIALLAFCEAVERYEKDKGYFLPFAKLVISSRIKNYLKSQNKHSCSSLDELVEKGIEIQDEYLEEEDNGLLVDDINILKSEIMLYGFTFEDLVEEAPKQRATRENAINLAKQISEVEELTNFMEIKKRLPIKKIVLRFSVTEKVVKRSKKFIISVVIIFKKDLKTLKNWIRK
>NZ_CP010520.1|WP_040968314.1|2208223_2209342_-|anti-sigma-factor-domain-containing-protein
MSKGIIMEIKKEYAIVMNDTGSIECIKIKDGMKLGQKIFYFEEDLVNINQNRSVNKISLFKTFGTFAALFLLIFTFFQPLAFNKAYAVVSLDINPSIQIQVNNKKKIVAVEGINEDGKNIDFSSVNGLEIDKGIDGIKAILVEKDYLNQMGEVLVAFALLDNEEDEKYENQIKDAIQTTFKTENVTYVKGSKEAVEEAKTKGISLGRYEVSLSADETVKSKIDNIPVKEITSLIKDKENCIYWKADDVQNSEKPETNNNLLDDKYSDKPENTLENNTLPKKDKVEEPIKEITPEVQKPVDNNKESEIKKDPEEVPETKPEIVLPPIEEIKPEGNTPSNEESEDKNNEITDNKNNGSENNMTDTGDIEQNLKK
>NZ_CP010520.1|WP_012450009.1|2205862_2207134_-|FAD-dependent-oxidoreductase
MYKNNDMKKNNEESISPVFAIEESSRCLLCHDAPCSQACPIGTNPAKFIRSLRFRNLKGAVETIRENNILGGVCARVCPTKKYCEGACSRTNIDKPIEIAKLQQYLTDYEKVLGLEILNKVEIDKEKVAIIGSGPSGLAAATKLAQLGYNVTVFEKREKLGGWLTYGIPEERLPQTVVNNEIEYIKNIGVEFKTNVNIGKDVTIDSLSKEGYKAFLIACGMQKSKEVKIDGSELDGVINGTDFLAEAKSTGKYKLGNKVIVIGGGDVAIDCAMTAKNLGSEDVKIVYRRTIEKMPAERKSIQEVIDLNIPIFTGIKPSEIIGENGKVLRFKGTGMFDDSNLDIPTENVIFAIGQEQEEVSSIANLDLNNKGIIETKEYATNIDGVFACGDIVEGDKTVVYALKLGKEAAEKVDQYLNEKEGAR
>NZ_CP010520.1|WP_012451722.1|2204624_2205863_-|NAD-dependent-dihydropyrimidine-dehydrogenase-subunit-PreA
MSIIKDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKAFEAGWGGVMFKTIGFFMPNEVSPRFDSLRKEATSFVGFKNMEQISDHPLQQNLDDLRRLKENYPTKIVVASIMGENEKEWEDLAKLVTEAGADMIECNFSCPQMTSHEMGSDVGQNPELVKKYCEATRRGTNLPILAKMTPNIGDMSVPAIASMEGGATGLATINTIKSITGIDINSMTAKPVVNAKSSVSGYSGKAVKPIALRFIYELAKNEKLKGVPISGIGGIETWEDALEFILLGSSNLQVTTSVMQYGYRVVEDMISGLSHFMDENGFEKLEDMVGIAIKNIIPAEDLDREYIVYPEVNEEKCLGCGRCYISCYDGAHQAIKWNSEERKPEVNKDRCVGCHLCALVCPVTAIGKGEIKFKNNGKEREIIL
>NZ_CP010520.1|WP_012451090.1|2203924_2204386_-|DUF1097-domain-containing-protein
MSSLFSLSLTTAILCGAWMIGADAAGLIAWAGFAGCTTFFAAGGKKQGFKSAICTNISGVFWAMLSIKVSAMLGFPQAGVIMTIVTTFFLCIQSKISLLAFIPGAFVGSFSTFAANGDWMSLIPSLLVGAVLGFLCEWTGNLLYEKCGKKEEN
>NZ_CP010520.1|WP_012449484.1|2202303_2203626_-|amino-acid-permease
MENNNLKKEISLFMATMLVCGNMIGSGVFMLPATLAQVSGPLATIIAWIITTIGSILIAISFANLGSKYPATGGAYQYTKEAFGEFTGFLSAWLYWNGSWIGNAAIIVALSSYSASIIPALQNPLASIIYTSSLLWIFTILNIVGVKEAGKIQTFVTVFKIAFFGVFIIAAFLNFDKINLMPLMPDGKGLSTIPLAATSTLWAFVGLESSTVTAGEIRDPEKNVRKSTIYGLIIASIIYILISVGSMGAMSNANLSNSSAPLTDILTNVFGNSIGKGLTIAVVICILGTTIGWLLSTARVSYAAGIDGVFPKFFGKLHPKYGTPINSLIAGSVLVNILLIMNYQKSMVSAFTFITILATLSFLPVYLLTVSAEMMLTFRDEKKFNFKIFMKKSTIPLLAFAYSIWTIYGSGAETVMWGFILMLIGIPFYIYNHYNSKQTS
>NZ_CP010520.1|WP_012451487.1|2201487_2202036_-|GNAT-family-N-acetyltransferase
MFKNLEKIEVRDFKSFFNLLEKSFPNIERRSREGQKEIFDDDLYKVYGVKDNVGNVVGFIATWEFDKFNFIEHFAVDASLRGNGMGTRLLKEYIQNSNKPIYLEVEYPNDDICIRRIDFYKRLGFNLNEFDYLQLPLQIGNELLPLKIMTYPSKVSNDKFIYFRKNVYEKVYKQNSCSNSKF
>NZ_CP010520.1|WP_012450578.1|2199951_2201034_-|alpha/beta-fold-hydrolase
MCKNIKKTIAIFTMMVLMTLCFELPYQQVFAFDKASLESIYVSEENYEEKMKDVVEPYIDNIKETGFVKGQEGIDIYYEMYKLNDSKGNIVISHGFSESLEKYNEIIYYFLNQGYSVFGLEHRGHGRSGSLGIKDKSQINVKDFEHYVLDLKELMDEVVVPNSDGEKVFLFAHSMGGGIGSKFLEEYPEYFDAAVLTSPMLEINTGKVPSSIAKLIANTSVALSFGDKYIAGQGKYDDTYDLKGSDTSSDARCRYYHSIVSGNDELQRGGASYNWLQTSIYATKEITKKDNAAKVEIPVMLMQADKDDFVKPGGQNNFTKYAQDCDKVFYEGSKHGLFRENDKILHDYLNNLFVFYEANL
>NZ_CP010520.1|WP_012450358.1|2217294_2217903_-|hypothetical-protein
MALITFSTPVNDNRNEIYYKSTCARNEKDKQEKRTEQEFYKESDYELMNKLKEKELELKERELDIKEEKIKIKEKEISINQREIDIKENTEKLNGLLIMLNKKENGLKEKEAKIHEMEIKVKESKEILDNLSMSFNKKEDELKEKESNLKQTEVKLSQKEQYLNKVEMNLKQIENKNNYNSNYKQGRNNRRDYYGNNYYDSF
>NZ_CP010520.1|WP_012449593.1|2218174_2219224_-|hypothetical-protein
MAKVNYINQASFHDPGVDCLKITEAPIIIKAETKVFSYKYVFSEADCNCSENCYPGKGDDVGFTLIFGNYGEETYTPTSTTDPTVIDTLDLSNIYNASLKVMDLCIGKNFKVFDITGVTPGSGQGREVIPGETEFIGGSVYTLEIRECYENPETGEKCTAAFCLPCHSVFCITMLFQVEFTPCSKLKNGGFCNGTTPSLENWIAIPATGGGTVQAVASYISSTNVNVTPKDGDCGFALLKTGDAEVKSILKQTFEVKAGDILSFYAFFDLMDIPGWPDEAQVIVIKNSSGNVIDTIVTKNAHYVSTDWEYYYYNVEECGTITFEASVKNGVDNISDGYLAIDAVSITHS
>NZ_CP010520.1|WP_012449590.1|2219438_2222591_-|DEAD/DEAH-box-helicase-family-protein
MKLLDLEFKLLRGLSKISLTRGKNIITDNKLVRLNGKKIEDSYNIYGKIKDDKLKEYNPHLRFNLKNGKVTLAKCECHEEKYDEDLGRMVICEHLVAIILTFFDKIKKQSNKDNIENVKKETVKYILDEKSNKELLDIDVVLNEVKDKNGDYFEANFFIGSKIKYLVNIKEFISNYIKKENFYIAKGFIYSYKKYYFNEDDEELIEFLEEYLSICRLELNTGNIKIFPQNIRRFLSFIQKKKIKFKYNYQNYLCDIKTTDLPISFTFKKIKEDYVLSTKKVFPIPLNKKMNAFLYDRKIYISSIKHLQSYIKFYEDLKEYGKIIFSKDTCIKDINKVIEVLNEISNDINIEQDIIDDLDKLISFKFKLTNIKNHRIIKVKIIRGNLELEYTNDNINSNYIIKRSRKVRNIESEMNKLRFFYNDGDFIFQGNDDEYYEFLKNGINNIKKMGEVNNFKEEKAFTLFDGSFLHYNLKSNNEEHTSFMFSLSDFSSSDLNKLYIGWKEKKSYIKLNDDSFVNLEDEDMTNFFKIVENLNLDIMSENNSYIVENNKLYYLNEKLNSKKYNVNGVEIFKEALNKLENLDDEKIFIPSNLNATLREYQVKGYRWLKNLSKLGFGGILADEMGLGKTIQIISFLLSEPNKKAFVITPTSLIYNWDEEFKKFAPSLKVGIIHGDLKARNKVLDDIEKYDLIITTYGTLRNDYLKYENIKFNYLIIDEAQNISNPKAKVTEVVKGIKANIRFALTGTPIENNLIDLWSLFDFIMPGYLFSKDEFSKKFTNNDEKSKQELRIMINPYILRRLKKDVIKELPNKIEDRFFVEMTKNQKKMYKIYVKDIQDKLKQIDSRNNRITIFAYLTRLRQLCLDPSIIVEDYDGGSGKINVAKELIKKSIKNNHKILLFSQFTSVLHKVCDELKGEQISYLYLDGSTPSKERIRLAHEFNNNEDIKIFLISLKAGGTGLNLTSADMVIHFDPWWNPAIEDQATDRAHRIGQKNVVRVIKLITKESIEEKILLLQEDKKALIEDVITGELKEDGLINKLSRDELLELLKI
>NZ_CP010520.1|WP_012451406.1|2222797_2223316_-|molecular-chaperone-DnaJ
MDPYKVLGLNEGASKDDIKERYQEIIGSYNESDQNEYNQSILKDVNIAYDVLVNGNLYKEVRSLIEKNNFLEAEAKLNVADDKTSAEWNYLQGFIAVQKGWFETALAYLKTSTEIEPNNIEYLDSLNKLQAKVMEFASNYARKNANNKNTNNNNNNMNACGGGGGGGNGGMC
>NZ_CP010520.1|WP_012450666.1|2223506_2225945_-|DNA-helicase-RecQ
MKSKELELLEKYYGYKSFRKGQENIISNIIDGNDVLAIMPTGGGKSICYQVPALIFEGLTIVISPLISLMKDQVDALKDMGINGEFINSSISSAEENRVIDNIRNGQCKILYVAPERLESLNFLNVISECSVSQIAIDEAHCISQWGHDFRTSYTKVSGFIKLLKTRPIITAFTATASEEVREDIIKLLNLNKPKIFITGFDRENLLINVIKSGDKKSYLHNYINNNKESSGVIYAATRKEVDKIHEELSHNGFSITKYHAGLSENDRKQNQEDFIYDRSNIMVATNAFGMGIDKPNIRFVVHYNMPKNIEGYYQEIGRAGRDGEKSECILLFSPQDVQIQKYLIEQSIENIDRKNNQYKKLNEMTDFVYSNECYRKYILDYFGEVYDHNCNNCSNCLNEGELVDKTIDAQKVLSCIYRMKNKFGSGMLVDVLRGSKNKKVIQFNFNELSTYGIMKDYSNDELKNFINTLISHRYISVVNGTYPVLGLNQRSMSVLKSEEKVVFKEFKIEKKAREDNELYSILKEIRKEISVENGVPPYVIFGDATLKEMTVKYPVNKEQMLNISGVGEIKYKKYGEIFENEIKKFIKENNIEISNEINEKEEVKMESIHLDINTNEELFNKLDEIRHEFAKKENTIPKMIISKNSLKEISGRYPINIDELKDISGIGPKKISLYGEKLILAVNDYIAQNNIEIKWVNRKKRKVIIDGEDREDNEIAIDMLKDGKKLNEICDEIEVSISTILGYVTDYIKEFGESNFDLNLEDFYNEEEEDIIGDVCEKIGYEKISAIKKQLPPYIKYETIRAVILKKYFLR
>NZ_CP010520.1|WP_012450102.1|2226343_2227141_-|glycoside-hydrolase
MKGIDISNHNGEIKFASVKSSGVELVYIKATEGTTYQDPMLNQYYNGANSEGLRTGFYHFLVGTSAPESQAQNFYDNIKGKTNDLKPCLDIEKNGFDVMDFALRFIKKFESLSGLPLCIYSYPYFINNNLDSRLAKYPLWVANYGVQTPIPNNVWGDSYVGHQYSETGNVNGINGNVDLDTFYDGILVNKIDKAYVVTQYLPNGYNGDGSFQGVDLNYVLSYMPGVRCYALGDSKGVWIETQMLTMEKCLELKQTLGSWFYDIRQ
>NZ_CP010520.1|WP_012451062.1|2227197_2227464_-|hypothetical-protein
MEKCLNEWNVHRYVRKQDREVLKTALKENVDRTFTPITVCSQIADGTNYMFICASIDNISKLKVELVKIYVYVSKDGKVQLNNIEKCN
>NZ_CP010520.1|WP_012450492.1|2227506_2227758_-|holin
MDFMTYISQNALILIPALYIVGMVIRGTESIPNKFIPFILLIIGIVGAMFLLGFNINGAIQGILVTGVTVYTNQLFKQYNKNE
>NZ_CP010520.1|WP_012451473.1|2228466_2229519_-|serine-protease
MKKAFLRRILGGVVAVATITSLSPLGVSAAGKNNTNNNCATTQCWSKVYGTWFCLGSNGQIQIGNQTTNNNPGCNLQFGWVTCPTQPNKPGDNNGSDNTIVPEVPGDNNGSNDTTVPEVPGDNNGSDDTTVPEVPGDNNGSNDTIVPEVPGDNNGSGNTTVPETPGDNNESENTSKPDNNGNNGTVKPEQPGDTEENLPPTSGDSVNVNGLSKLPEKYSISVQSSAENKILQLMNEKRVQAGLKPLTMDNTLLQVARYKSNHMIQYNYFDHTNPDGTKWVNWLQTIGYKYNTTGENIAYNTYDPVELFNQWWNSQGHRENMMNPSYTKVGVGVVYDKDNNKYMGTQTFSN
>NZ_CP010520.1|WP_040968315.1|2229903_2233419_-|pyruvate:ferredoxin-(flavodoxin)-oxidoreductase
MRRTKTMDGNTAAAHISYGFTEVAAIYPITPSSPMAEHVDEWASQGRKNIFGEPVKMVEMQSEAGAAGAMHGSLQAGALTTTYTASQGLLLMIPNMYKIAGEKLPCVMHVSARALATSSLSIFGDHQDVMAARQTGFAMLAETSVQEVMDLSGVAHLAAIKGKIPFVNFFDGFRTSHEIQKIEVIEQDELAKLVDYNAIDEFRKNSLNPNHPVTRGTAQNPDIYFQTREAVNKAYDDVPSIVEEYMSEITKLTGREYHCFDYYGAKDADRIIISMGSVNDVVEETVDYLNNNKQKVGLVKVRLYRPFSVERLLKVIPKSVKKIAVLDRTKEPGAIGEPLYLDVVRCLYGKKDAPIIVGGRFGLGSKDPTPSHIAAVFDNLISDEPKNQFTIGITDDLTNTSLKLHEDINATPEGTTSCKFWGLGSDGTVGANKSAIKIIGDHTDMYAQGYFDYDSKKSGGITVSHLRFGKELIKSRYLIDKADFIACHNQSYVYKYNVLKGLKKNARFLLNTIWDKDELDEKLPASMKKFIAENDIEFYTINAIKIAQEIGLGGRINMIMQAAFFKITNIIPVEDAVKYLKEAVVNSYGKKGEKVVRMNNDAIEAGVEGVVKIEIPAGWKNSIDEKNEFSKDLPAFIREIVNPMNRLEGDSLPVSTFVKHNLEDGTFMAGTTAYEKRGIAVNVPEWLQDKCIQCNQCSYVCPHATIRPFLLNEEEKSKAPSSIKLIEPKALKSDEKLYYSIGVTPLDCTGCGNCVEVCPAPGKALIMKPQASQHDQIEVWDYTVEKVTNKNPMNKNTVKGSQFEIPLLEYSGACAGCGETPYAKLITQLFGDRMMIANATGCSSIWASGAPATAYTKNQQGHGPAWANSLFEDNAEFGYGMHLGVKAIRERIAHNIEVALNSDLSENTKEVLKDWLDHKDCGEGTRDRSNKVIEVLEKENNELAKVILKDKEFLVNRSQWIFGGDGWSYDIGYGGLDHVIASGENVNIFIFDTEIYSNTGGQASKSTPTAAIAKFAASGKRTKKKDLGMIAMTYGYVYVAQIAMGADKNQTLKAICEAENYDGPSLIIAYAPCISHGIKIGMSNSQEEEKKAVECGYWSLYRYNPTLKGVKNPFSLDSKEPKGNFREFLMGEVRYSSLAKVFPELSEELFKKTEEDAIERYNNYKKLASQE

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Crispr_ID: NZ_CP010520_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010520_5

2684430-2684524

Orphan

Consensus_repeat	Method
AAAAGTTATTTACATATGTTTAGTTCTTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010520_5

>merge|NZ_CP010520|5|2684430-2684524|CRISPRCasFinder
AAAAGTTATTTACATATGTTTAGTTCTTATGTTATTAAACGCAGGAAACAACGACCCTCCTAAGAAAAAGTTATTTACATATGTTTAGTTCTTAT

>NZ_CP010520|5|4|2684430-2684524|CRISPRCasFinder
AAAAGTTATTTACATATGTTTAGTTCTTAT	GTTATTAAACGCAGGAAACAACGACCCTCCTAAGA
AAAAGTTATTTACATATGTTTAGTTCTTAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010520.1\|WP_012451856.1\|2687108_2687795_-\|methionine-synthase	unknown	unknown	unknown
NZ_CP010520.1\|WP_003374514.1\|2692844_2693486_-\|V-type-ATP-synthase-subunit-D	unknown	unknown	gnl\|CDD\|178991
NZ_CP010520.1\|WP_012451634.1\|2684707_2687119_-\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|273959
NZ_CP010520.1\|WP_012450429.1\|2688293_2689172_-\|methylenetetrahydrofolate-reductase-[NAD(P)H]	unknown	unknown	gnl\|CDD\|273212
NZ_CP010520.1\|WP_012451064.1\|2677534_2678449_-\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NZ_CP010520.1\|WP_003369464.1\|2689441_2690392_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NZ_CP010520.1\|WP_012449558.1\|2679086_2679302_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012450205.1\|2687796_2688252_-\|S-ribosylhomocysteine-lyase	unknown	unknown	gnl\|CDD\|179399
NZ_CP010520.1\|WP_012450476.1\|2680877_2683163_-\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|226482
NZ_CP010520.1\|WP_012449949.1\|2675486_2675738_-\|holin	unknown	unknown	gnl\|CDD\|377377
NZ_CP010520.1\|WP_012449927.1\|2674494_2675328_+\|PHP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223686
NZ_CP010520.1\|WP_012449497.1\|2683676_2684222_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012450114.1\|2690749_2692498_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|223808
NZ_CP010520.1\|WP_003373988.1\|2696657_2696969_-\|V-type-ATP-synthase-subunit-F	unknown	unknown	gnl\|CDD\|179293
NZ_CP010520.1\|WP_003371054.1\|2680526_2680778_-\|DUF1292-domain-containing-protein	unknown	unknown	gnl\|CDD\|184235
NZ_CP010520.1\|WP_012449728.1\|2678465_2678654_-\|DUF896-domain-containing-protein	unknown	unknown	gnl\|CDD\|368690
NZ_CP010520.1\|WP_012451502.1\|2680114_2680513_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_003372165.1\|2694861_2696640_-\|V-type-ATP-synthase-subunit-A	unknown	unknown	gnl\|CDD\|235248
NZ_CP010520.1\|WP_012451787.1\|2675966_2677358_-\|aminopeptidase	unknown	unknown	gnl\|CDD\|235018
NZ_CP010520.1\|WP_003370262.1\|2693489_2694869_-\|V-type-ATP-synthase-subunit-B	unknown	unknown	gnl\|CDD\|235251

Protein	Function_ID	Function_description	E-value
NZ_CP010520.1\|WP_003373988.1\|2696657_2696969_-\|V-type-ATP-synthase-subunit-F	gnl\|CDD\|179293	PRK01395, PRK01395, V-type ATP synthase subunit F; Provisional.	3.73495e-60
NZ_CP010520.1\|WP_003374514.1\|2692844_2693486_-\|V-type-ATP-synthase-subunit-D	gnl\|CDD\|178991	PRK00373, PRK00373, V-type ATP synthase subunit D; Reviewed.	9.08503e-97
NZ_CP010520.1\|WP_012451634.1\|2684707_2687119_-\|dihydropteroate-synthase	gnl\|CDD\|273959	TIGR02082, Methionine_synthase, 5-methyltetrahydrofolate--homocysteine methyltransferase. This family represents 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13), one of at least three different enzymes able to convert homocysteine to methionine by transferring a methyl group on to the sulfur atom. It is also called the vitamin B12(or cobalamine)-dependent methionine synthase. Other methionine synthases include 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (MetE, EC 2.1.1.14, the cobalamin-independent methionine synthase) and betaine-homocysteine methyltransferase. [Amino acid biosynthesis, Aspartate family].	2.88753e-153
NZ_CP010520.1\|WP_003369464.1\|2689441_2690392_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	2.31186e-73
NZ_CP010520.1\|WP_012451064.1\|2677534_2678449_-\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.34957e-153
NZ_CP010520.1\|WP_012450205.1\|2687796_2688252_-\|S-ribosylhomocysteine-lyase	gnl\|CDD\|179399	PRK02260, PRK02260, S-ribosylhomocysteine lyase.	7.16039e-79
NZ_CP010520.1\|WP_012451787.1\|2675966_2677358_-\|aminopeptidase	gnl\|CDD\|235018	PRK02256, PRK02256, putative aminopeptidase 1; Provisional.	0
NZ_CP010520.1\|WP_012449949.1\|2675486_2675738_-\|holin	gnl\|CDD\|377377	pfam04531, Phage_holin_1, Bacteriophage holin. This family of holins is found in several staphylococcal and streptococcal bacteriophages. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis.	5.42311e-07
NZ_CP010520.1\|WP_012450429.1\|2688293_2689172_-\|methylenetetrahydrofolate-reductase-[NAD(P)H]	gnl\|CDD\|273212	TIGR00676, 510-methylenetetrahydrofolate_reductase., 5,10-methylenetetrahydrofolate reductase, prokaryotic form. The enzyme activities methylenetetrahydrofolate reductase (EC 1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC 1.7.99.5) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in bacteria, and currently designated 1.7.99.5. This protein is an FAD-containing flavoprotein. [Amino acid biosynthesis, Aspartate family].	6.09798e-121
NZ_CP010520.1\|WP_012450114.1\|2690749_2692498_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|223808	COG0737, UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism].	3.91874e-108
NZ_CP010520.1\|WP_003371054.1\|2680526_2680778_-\|DUF1292-domain-containing-protein	gnl\|CDD\|184235	PRK13678, PRK13678, hypothetical protein; Provisional.	2.61651e-15
NZ_CP010520.1\|WP_012449728.1\|2678465_2678654_-\|DUF896-domain-containing-protein	gnl\|CDD\|368690	pfam05979, DUF896, Bacterial protein of unknown function (DUF896). In B. subtilis, one small SOS response operon under the control of LexA, the yneA operon, is comprised of three genes: yneA, yneB, and ynzC. This family consists of several short, hypothetical bacterial proteins of unknown function. These proteins are mainly found in gram-positive firmicutes. Structures show that the N-terminus is composed of two alpha helices forming a helix-loop-helix motif. The structure of ynzC from B. subtilis forms a trimeric complex. Structural modelling suggests this domain may bind nucleic acids. This family is also known as UPF0291.	5.47468e-11
NZ_CP010520.1\|WP_012449927.1\|2674494_2675328_+\|PHP-domain-containing-protein	gnl\|CDD\|223686	COG0613, COG0613, Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only].	8.27694e-48
NZ_CP010520.1\|WP_003372165.1\|2694861_2696640_-\|V-type-ATP-synthase-subunit-A	gnl\|CDD\|235248	PRK04192, PRK04192, V-type ATP synthase subunit A; Provisional.	0
NZ_CP010520.1\|WP_012450476.1\|2680877_2683163_-\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	2.82203e-160
NZ_CP010520.1\|WP_003370262.1\|2693489_2694869_-\|V-type-ATP-synthase-subunit-B	gnl\|CDD\|235251	PRK04196, PRK04196, V-type ATP synthase subunit B; Provisional.	0

>NZ_CP010520.1|WP_012449497.1|2683676_2684222_-|hypothetical-protein
MNNKIKQMVYAALLTALAIIIPIQFGFLKVVIPPFTATLASHVPMMLAMLISPAVSIVVGIGSALGFLISGMPMVVVFRAATHILVGYVGAKIMIKSRNYMKATIITAPIHGIAEMVVVIPFIGFDLFQLLIVTAVGTIIHHFIDGAIAYSLAKAMSKARKTDIYHVFGEFCEDKDVQAQI
>NZ_CP010520.1|WP_012450476.1|2680877_2683163_-|UvrD-helicase-domain-containing-protein
MKSELLYEEEILEEKRSLILEELNEKRINREKVNEKIRYLSKESKGSYNEEKETTEKIYGVLQKDIDGYEEALETPYFGRVDFTEKFGFEENIYIGKKGITNNMRGEEVVVDWRAPIADLYYSGTGGEAYYKAPAGLIEGKLLLKRKFLFDDGKIKDIFDDSLNELMINGEEGTELVDEFLKINLEESRGKKLKEVVSTIQKEQNEIIRWPKNFPIIVQGSAGSGKTTIALHRLAYLIYRYKDSMKGDDILVLAPNKLFLDYISETLPNLGAEEVQQNTFEELVKSKFKLRGKIYSKDDKLRAIMEEDDDNKRNLIIKSAGFKGSIEFKNMIDKYIALVDSSTREIEDITIDGYVIFEKKEIVKLYLKDLKSYAINKRKDEIKRYLSLKIKEKIDVLLYSIDFRWESKIKNIKNTCEDLIERRKLLVEEYDKRDEIKNHILKNYKKQFNEYFKSWKGIGVSDIYYRFFTDDLFDFIGPENISSELLDFMKEDFLINYENKIIDEDDLAPLLYIRNLLEGIDEKEKFKHIVVDEAQDYSPFQIHLINSFSKGNSLTLVGDLAQGIYYYKGLKCWEDITKDLFQDKATYVQLTQSYRSTVEIIDFAKHTLKAQNLGLKDAKAVLRHGEEPKIIKFDESEKNIYKIIDKIIEKIRELGKISIAIITKDSKQAQKVEKILKNNSAYKFQRIKGKEACFLEDNVIIPSYLTKGLEFDCTIIYNPSKENYQNNILDQRLLYVMLTRALHYEYILKLDSLTHLIEENN
>NZ_CP010520.1|WP_003371054.1|2680526_2680778_-|DUF1292-domain-containing-protein
MEEKEIMSFKDEAGNKVDFEAIARIYLDKTEYLLLSPVDESSDDANIFAFRVDRNKDDKEELNIVEDEKEFEAIKKEYKKLLY
>NZ_CP010520.1|WP_012451502.1|2680114_2680513_-|hypothetical-protein
MKSSEIIEYLEKNGLSEVEEINITDEYILIKFFYDFDKEEIDAAENYANEDCDFDDDSDEWYNDFYMPYLNDIAMDNIESIIEEAMEDLDIEGKYRQIESETRNLGYVKFISVFANSDSEVDLDEVLIDYND
>NZ_CP010520.1|WP_012449558.1|2679086_2679302_+|hypothetical-protein
MKIKDLLKLKRKIIVRKKLLNFLLVWFNPRNTLMIVLSKNLDKHIAKYQKILSLQHRHEKYRLDMVRLAIA
>NZ_CP010520.1|WP_012449728.1|2678465_2678654_-|DUF896-domain-containing-protein
MNIENMKIEEVIEQINLLYKKSKEASLTEEEKELQQKLRKRYIDNVKKNFRAQLEGVELKNK
>NZ_CP010520.1|WP_012451064.1|2677534_2678449_-|HPr-kinase/phosphorylase
MAVSVKRLINDFDLEVLVEGNEDVKIEVNDVNRPGLQLAGFYNYFAPERIQIIGKAEWSFLQDMQIEVRKKRVKKYLSFNITCLIISRGLDPHEEFIKEARKNNIWVLRSKSVTTKLISKITLYLADKLAPETRLHGVLVDVSGIGILITGESGIGKSETALELIKRGHRLITDDAVDIRESDGTLIGSSPKITIGMLEVRGIGIIDVTQLYGLSSVLEEKEIKLIMHFEHWKDDNDYDRLGIDNQYMDILGIPVKKLTVPVRPGRNIAVIIEAAAVNYRYSLMSKISPVDIIENRMSAVSDEA
>NZ_CP010520.1|WP_012451787.1|2675966_2677358_-|aminopeptidase
MKSEKNNKNVWNKYEEKGVKEIFDFCDGYKNFMSICKTERECVKEVIKMAEDNGYKNIDDIIKNGGALKAGDKVYANNKGKTIALFIIGNESMEKGLKILGAHIDSPRLDAKQNPLYEDNEMVLLDTHYYGGIKKYQWVTLPLALHGVVVKKDGSIIDICIGEDESDPVVGVSDLLVHLSGDQLLKKGNKVVEGEDLNVLVGSMPLKGEEKDAVKANILKILKEKYDFEEEDFLSAEIEIVPAGKARDYGLDRSMVMAYGHDDRVCSYTSLMAMFDINECDKTCCCLLVDKEEVGSIGATGMQSKFFENIVAEVLDKVEGFSDIKLRRCLSNSKMLSSDVSAAFDPNYPSVMEKKNSAFFGRGMVFNKYTGARGKSGCNDANAEYMAELRRIMEKHDVSIQTAELGKVDAGGGGTIAYILAQYNMEVIDCGVALLNMHAPWELASKADIYETMRGYRAFLIEA
>NZ_CP010520.1|WP_012449949.1|2675486_2675738_-|holin
MIDKSRFKNYGLWVSIAALIPLILKSFGVEVIQGDYEQIVQAILSILVMLGIVSNPTTDAKWFSDDKALEEPKNVEIDSKDSK
>NZ_CP010520.1|WP_012449927.1|2674494_2675328_+|PHP-domain-containing-protein
MYKMDFHIHTSSSDGLLSPTEVVKRAKENSVSYLAITDHDTLSGLDAGIKCGKELGVTIIPGIELSTQYNNESIHLLGFFKDNNFNNSKLINELDKIKNHRIIRAKEIIKKLKSEFNIIISFDDVLANGKDTIARPHIARAIIDAGYDYDNEYIFQNFIGKDCKAYVPTLKLSTEDGISLLKSYNALVFLAHPKLISNSKIDDFLKMDLDGIEAIYFQNTKVEEEKFINIAIENNLLISCGSDFHGNLKDDKKHGDIGSMTMPSIYLENLLSALNIK
>NZ_CP010520.1|WP_012451634.1|2684707_2687119_-|dihydropteroate-synthase
MGLREFIKDNILVFDGAMGTMLQKEGLKLGENPEIFNIEESEKVKNVHKKYIENGAMVVTTNTFGANELKLDNTKYTVEEIIDAAISIAKGARENKGIYIALDIGPIGELLEPMGTLSFERAYDIFKRQMIQGEKSGADLILIETMTDLYEAKAALLAAKENTKLPVFCTMSFDESGRTFTGCTPESMALTLGGMGADAIGINCSLGPKELLPIVKRIKKATNLPIMTQPNAGLPKLSFGEAIYDIMPEEFKYWVNEFIKEGVSIIGGCCGTNPEFIKELRLLADSNKRLRRENIEFSAVCTPSKVVKIEGVKIIGERINPTGKKLFKEALKNNDIDYILKQAIEQVEAGADILDVNVGLPEINEKEMMKKVVKEIQGIIDTPLQIDSSNIEAVEAGLRTYNGKPIVNSVNGEDEVLEKVLPLVKKYGASVVGLTLDKKGIPATADERFKIAEKIVKKAKEYGIEKHDVFIDCLVLTASAQQAEVKETLKALRKVKEELGVKTLLGVSNISFGLPCRELINETFLAMAIANGLDLPIMNPNSTGMMDVINSYNVLTNIDKGCERYISIYGNREIQSGVRYNSKGENKSDKNEETQSNNSDLRYIVIKGLKDEAEEATKNILESMNELDVVNEILIPSLDEVGLKYEKGEIFLPQLIQCAETVKKSFEVIKKNIVINKSENISKGKIVLATVKGDIHDIGKNIVKVILENYGYEIIDLGKDVPIETVVDAVLKNDIRLVGLSALMTTTLKSMKETIKALKDNGYSGKTFVGGAVLTSEYAKEICADYYAKDAKESVEIAKKILG
>NZ_CP010520.1|WP_012451856.1|2687108_2687795_-|methionine-synthase
MCNTKQLKIPKDEVLRYLGYKKQKLSESMNELIEETIDECRNLIIPKQVYCKYKKHDENDGVYIYKTNLILKGEDIKNHLLYANEVFIIAATVGNKIEQKIRLYEKINLTKALILDACATVAIEEFLDELEEKIRLDARKEDLAITFRYSPGYGDLPLDIQKDIVNVLNADKTIGLTVSSHSLLFPRKSVTAIIGLIPIEKEEKQRGCEVCKNYNNCNFRKEGINCGA
>NZ_CP010520.1|WP_012450205.1|2687796_2688252_-|S-ribosylhomocysteine-lyase
MEKVESFELDHRKVKAPYIRKCCLLDGKCGDKVTKFDIRFLQPNKEEFGTAAMHGLEHLLAHELRAKLEGIIDLSPMGCRTGFYLSIWGDREASEIKEALEYSLEKVLEAKEIPAANDIQCGNYRDLSLFGAKEYAKEALERGFSLNIYGE
>NZ_CP010520.1|WP_012450429.1|2688293_2689172_-|methylenetetrahydrofolate-reductase-[NAD(P)H]
MNIKNLFKDKKVVFSFEIFPPKTTSSIQTIYDTLDDLKGLNPDYMSVTYGAGGSVKNNNTIELSSLIKNKYGIEPVSHLTCINLTKKDVEYYLREFEKNNIENILALRGDVPIGSKITGELNHANELIKYISDNGNFNIAAACYPEGHIEHKGLYREIESMKRKEEAGVSYFISQLFFDNNLYYNFQDEVRAANINLPIEAGIMPVTNKRQIERILSLSGASLPDKFKRIMERYEHNPEALRDAGIAYAVEQIVDLISTGVDGIHLYIMNNPYVAKRISQSIQSILLTVNQI
>NZ_CP010520.1|WP_003369464.1|2689441_2690392_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MQYILAMIVTLLLSLLIMPIVMKLAIKLKFTDKPTKRKQHKKETPLCGGIVLYICFFISFFLFVKDDIKQQIVVFIAATAILLIGLIDDYYKTRFKEFAILPRLIIQLLSAVLVFKAGIAFMGFTNPFTGEFIELSKTIQFLLTITWIFGVTTVINWSDGMDGLAGGISLISAITFLLAAIILKQQVSAETSIILIGSILGFLYYNKFPAKVFMGDSGANFLGFILSVIALDGAFKQATVLSLFIPILALAVPIFDNLFVIFKRFSEGKPVYQADRSQIHFRLEEKGFTPKQVVNYIMIISSVFSAISVILLLIKI
>NZ_CP010520.1|WP_012450114.1|2690749_2692498_-|LysM-peptidoglycan-binding-domain-containing-protein
MKKKILSAMLSLTLVFSLNTTSVWAASKDDSTKITIIHTNDTHSRVLSADGGFGFAKIATIVNETKKENPNTLLVDAGDTLHGKPIVNVSKGENAIKILDAAGYDFMVPGNHDFNYGNERLMELSKLAKNFKMLDANVKKNGKDMLPPYEIVEKGNVKIGIFGLSTPETAYKTNPANVKDVTFEDPIKVSEEMVKELKDKTDVIVALAHVGLDDSSVVTSKQIAEKVKGIDVIIDGHSHTTLNDGLMVNNTLIAQTGEYDQNLGVVELEVKDKKVTEKKAKLLNSKDYKELKEDEKVTDLLNDIQAENDKVFSEVVASNDVLLDGVRGNVRTKETNLGNLTADATREVTKADIAFVNGGTLRTSIEPGDITKGKLAELFPFGSVAQTVKLSGSDIVNALEVSVGAYPTEQGGFLQVSGMTFSFDPTKEKGNRTFDVKVGENPIDLNKEYTVAINDFLSQGGDGYTMLKTTVVGEFATYDDIFAKYLNDNGMKNDISLGRVQVKENGKQVVTNQNNVVTAPVVQTVQTPQEPVKTETVYTVIAGDNLTKIARRNNTTWQTLAQYNNLQNPDLIYVGDQIKIPA
>NZ_CP010520.1|WP_003374514.1|2692844_2693486_-|V-type-ATP-synthase-subunit-D
MAKLNVNPTRMELSKLKKRLTTSTRSHKLLKDKQDELMRQFINLVKYNNKLRKEVEDNLQGSLKDFVMARAVMSSEFLEEAIVYPKEHISVEVGEKNVMSVSVPVMNFKRQLEGDEGSIYPYGFANTSSELDDTLSKLYEILPQLLELAEVEKSCQLMANEIESTRRRVNALEYMTIPQLQETIKYIRMRLDENERSATTRLMKVKSMIEQRG
>NZ_CP010520.1|WP_003370262.1|2693489_2694869_-|V-type-ATP-synthase-subunit-B
MLKEYRTVTEVVGPLMVVEGVEGVKYDELVEIELHTGEKRRGKVLEVNGSKAMVQIFEGSSGINLKGTKAKFLGRPLELGVSEDMLGRVFDGMGRPNDNGPDIIPEKRVDINGEAINPMARDFPSEFIQTGVSAIDGLNTLVRGQKLPVFSAAGLPHAELAAQIARQAKVLNSDSKFAIVFAAIGITFEEAQFFQDEFKRTGAIDRSVLFMNLASDPAIERIATPRMALTCAEYLAYEKGMQVLVIMTDITNYAEALREISAARKEVPGRRGYPGYLYTDLSTLYERAGRLRGKEGSITQIPILTMPEDDKTHPIPDLTGYITEGQIILSRELYKKGIMPPIDVLPSLSRLKDKGIGKGKTREDHADTMNQLFAAYSQGKQAKELSAILGESALSDTDKKLAKFAEAFEDEYVSQGFNTNRTIEETLNLGWKLLKMLPRTELKRIRDEYLEKYMPREEE
>NZ_CP010520.1|WP_003372165.1|2694861_2696640_-|V-type-ATP-synthase-subunit-A
MKTGKIIKVSGPLVVAEGMDEANIYDVCKVGEKGLIGEIIEMRGDKASIQVYEETSGIGPGDPVVTTGEPLSVELGPGLIESMFDGIQRPLDAFMEAAKSSFLTRGVSVPSLNREKKWDFKPTAKVGDEVKSGDVIGTVQETPVVEQRIMIPIGIEGKIKEINAGSFTVTETIAIVETEKGDREVQLMQKWPVRKGRPYSAKINPVEPMLTGQRVIDTFFPVAKGGAAAIPGPFGAGKTVTQHQIAKWGDAEIVVYVGCGERGNEMTDVVNEFPELIDPKTGESLMKRTVLIANTSNMPVAAREASIYTGITIAEYFRDMGYAVSIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRLADYYERAGKVECLGNDGRIGSITAIGAVSPPGGDISEPVSQSTLRIVKVFWGLDAQLAYQRHFPTINWLTSYSLYADTIDKWMNGNVAENWGALRLEAMTILQDEAQLQEIVRLVGIDALSEKDRLKLDVAKSIREDYLQQNGFHEIDTYTSLKKQYKMLSLILGYRKEAERALEAGVYLNDILAMEDLKDRIARSKYIHEDDLEKMDQIVVDLKNAIDNLINKGGVANA
>NZ_CP010520.1|WP_003373988.1|2696657_2696969_-|V-type-ATP-synthase-subunit-F
MFKKIGVVGDKDSVLAFKALGIDVFPVVGNEEAKKTVDKLAKNDYAVVFVTEHVAQGIEETIERYNKEVLPAVILIPSNQGTLNIGMQRISDNVEKAVGVNIL

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Crispr_ID: NZ_CP010520_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP010520_6

3150302-3150385

Orphan

Consensus_repeat	Method
CCAGTTTGCATAGCACCATTTCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP010520_6

>merge|NZ_CP010520|6|3150302-3150385|CRISPRCasFinder
CCAGTTTGCATAGCACCATTTCCTAATAGGTAGTACCAAGCTCCGTTAACATTTTGCCATCCAGTTTGCATAGCACCATTTCCT

>NZ_CP010520|6|5|3150302-3150385|CRISPRCasFinder
CCAGTTTGCATAGCACCATTTCCT	AATAGGTAGTACCAAGCTCCGTTAACATTTTGCCAT
CCAGTTTGCATAGCACCATTTCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP010520.1\|WP_012450059.1\|3133207_3134812_-\|N-acetylmuramoyl-L-alanine-amidase-family-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP010520.1\|WP_012450432.1\|3156613_3157108_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012450307.1\|3135146_3136859_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP010520.1\|WP_012451855.1\|3143083_3145318_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP010520.1\|WP_003373918.1\|3158917_3159766_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133016
NZ_CP010520.1\|WP_003373150.1\|3160806_3161037_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|180828
NZ_CP010520.1\|WP_012450883.1\|3140685_3142500_-\|N-acetylmuramoyl-L-alanine-amidase-family-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP010520.1\|WP_012450702.1\|3137438_3137756_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP010520.1\|WP_012450830.1\|3157941_3158676_-\|phage-protein	unknown	unknown	gnl\|CDD\|370614
NZ_CP010520.1\|WP_012451553.1\|3152532_3154014_+\|DUF2334-domain-containing-protein	unknown	unknown	gnl\|CDD\|200549
NZ_CP010520.1\|WP_012450041.1\|3147639_3149946_-\|surface-protein-PspA	unknown	unknown	gnl\|CDD\|227588
NZ_CP010520.1\|WP_012451415.1\|3132046_3132922_-\|surface-protein-PspC	unknown	unknown	gnl\|CDD\|227588
NZ_CP010520.1\|WP_012451496.1\|3162618_3163977_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238860
NZ_CP010520.1\|WP_012449881.1\|3145578_3147252_-\|choline-binding-protein-A	unknown	unknown	gnl\|CDD\|227588
NZ_CP010520.1\|WP_012450659.1\|3159885_3160719_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP010520.1\|WP_012451436.1\|3161083_3162598_-\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|341253
NZ_CP010520.1\|WP_012449860.1\|3157100_3157616_-\|DUF3990-domain-containing-protein	unknown	unknown	gnl\|CDD\|379042
NZ_CP010520.1\|WP_012451156.1\|3130539_3131886_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP010520.1\|WP_012450441.1\|3138084_3140589_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225461
NZ_CP010520.1\|WP_012450989.1\|3154122_3156162_-\|M13-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341056

Protein	Function_ID	Function_description	E-value
NZ_CP010520.1\|WP_012450059.1\|3133207_3134812_-\|N-acetylmuramoyl-L-alanine-amidase-family-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	2.37413e-33
NZ_CP010520.1\|WP_012450307.1\|3135146_3136859_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	1.94261e-48
NZ_CP010520.1\|WP_012451855.1\|3143083_3145318_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	3.768e-43
NZ_CP010520.1\|WP_003373918.1\|3158917_3159766_-\|glycosyltransferase	gnl\|CDD\|133016	cd02525, Succinoglycan_BP_ExoA, ExoA is involved in the biosynthesis of succinoglycan. Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.	7.14383e-07
NZ_CP010520.1\|WP_012450883.1\|3140685_3142500_-\|N-acetylmuramoyl-L-alanine-amidase-family-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.76902e-39
NZ_CP010520.1\|WP_012450702.1\|3137438_3137756_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.3227e-16
NZ_CP010520.1\|WP_012450830.1\|3157941_3158676_-\|phage-protein	gnl\|CDD\|370614	pfam09681, Phage_rep_org_N, N-terminal phage replisome organizer (Phage_rep_org_N). This entry represents the N-terminal domain of a small family of phage proteins. The protein contains a region of low-complexity sequence that reflects DNA direct repeats able to function as an origin of phage replication. The region is N-terminal to the low-complexity region.	1.78863e-41
NZ_CP010520.1\|WP_012451553.1\|3152532_3154014_+\|DUF2334-domain-containing-protein	gnl\|CDD\|200549	cd10923, CE4_COG5298, Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria. This family corresponds to a group of uncharacterized bacterial proteins with high sequence similarity to the catalytic domain of the six-stranded barrel rhizobial NodB-like proteins, which remove N-linked or O-linked acetyl groups from cell wall polysaccharides and belong to the larger carbohydrate esterase 4 (CE4) superfamily. Some family members contain an additional copper amine oxidase N-terminal domain.	7.57046e-58
NZ_CP010520.1\|WP_012450041.1\|3147639_3149946_-\|surface-protein-PspA	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	5.26306e-29
NZ_CP010520.1\|WP_012451415.1\|3132046_3132922_-\|surface-protein-PspC	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.51793e-18
NZ_CP010520.1\|WP_012451496.1\|3162618_3163977_-\|hypothetical-protein	gnl\|CDD\|238860	cd01822, Lysophospholipase_L1_like, Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity.	0.000166752
NZ_CP010520.1\|WP_012449881.1\|3145578_3147252_-\|choline-binding-protein-A	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	2.22652e-32
NZ_CP010520.1\|WP_003373150.1\|3160806_3161037_-\|acyl-carrier-protein	gnl\|CDD\|180828	PRK07081, PRK07081, acyl carrier protein; Provisional.	0.00753822
NZ_CP010520.1\|WP_012451436.1\|3161083_3162598_-\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|341253	cd05930, A_NRPS, The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.	6.29311e-129
NZ_CP010520.1\|WP_012449860.1\|3157100_3157616_-\|DUF3990-domain-containing-protein	gnl\|CDD\|379042	pfam13151, DUF3990, Protein of unknown function (DUF3990). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	6.40567e-64
NZ_CP010520.1\|WP_012451156.1\|3130539_3131886_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	4.88853e-37
NZ_CP010520.1\|WP_012450441.1\|3138084_3140589_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	1.22852e-17
NZ_CP010520.1\|WP_012450989.1\|3154122_3156162_-\|M13-family-metallopeptidase	gnl\|CDD\|341056	cd08662, M13, Peptidase family M13 includes neprilysin and endothelin-converting enzyme I. The M13 family of metallopeptidases includes neprilysin (neutral endopeptidase, NEP, enkephalinase, CD10, CALLA, EC 3.4.24.11), endothelin-converting enzyme I (ECE-1, EC 3.4.24.71), erythrocyte surface antigen KELL (ECE-3), phosphate-regulating gene on the X chromosome (PHEX), soluble secreted endopeptidase (SEP), and damage-induced neuronal endopeptidase (DINE)/X-converting enzyme (XCE). Proteins in this family fulfill a broad range of physiological roles due to the greater variation in the active site's S2' subsite allowing substrate specificity. NEP is expressed in a variety of tissues including kidney and brain, and is involved in many physiological and pathological processes, including blood pressure and inflammatory response. It degrades a wide array of substrates such as substance P, enkephalins, cholecystokinin, neurotensin and somatostatin. It is an important enzyme in the regulation of amyloid-beta (Abeta) protein that forms amyloid plaques that are associated with Alzeimers disease (AD). ECE-1 catalyzes the final rate-limiting step in the biosynthesis of endothelins via post-translational conversion of the biologically inactive big endothelins. Like NEP, it also hydrolyzes bradykinin, substance P, neurotensin, and Abeta. Endothelin-1 overproduction has been implicated in various diseases including stroke, asthma, hypertension, and cardiac and renal failure. Kell is a homolog of NEP and constitutes a major antigen on human erythrocytes; it preferentially cleaves big endothelin-3 to produce bioactive endothelin-3, but is also known to cleave substance P and neurokinin A. PHEX forms a complex interaction with fibroblast growth factor 23 (FGF23) and matrix extracellular phosphoglycoprotein, causing bone mineralization. A loss-of-function mutation in PHEX disrupts this interaction leading to hypophosphatemic rickets; X-linked hypophosphatemic (XLH) rickets is the most common form of metabolic rickets. ECEL1 is a brain metalloprotease which plays a critical role in the nervous regulation of the respiratory system, while DINE is abundantly expressed in the hypothalamus and its expression responds to nerve injury. A majority of these M13 proteases are prime therapeutic targets for selective inhibition.	0

>NZ_CP010520.1|WP_012450041.1|3147639_3149946_-|surface-protein-PspA
MREFMRHIHFKPIAMILTILFIQVAFILYLPCKDSYIAYADEVLHKDDTEKSYELSENLIGKSTELMSDENVLSNTENNQVDIILKDFNESHIVKESDNTENTESKHDKVQGESNNTTDGDNIIDKDDNASEKPDEGNTDETEQGGSSGNESSGGSDEDVPPEIDNKKQAIVPSINSFAEDMGKNREKLTVSATNINAQGEYTFIILASDKLNVCKHSATNSTLNKWFIPLIELSKGEQKLSYSTDGKNFFELSLDSNNKIPYYMRANITGAPNYTEKERDSILYFKYAEDGGDTAIKIRIHYIPSINANDNNNSGNVSGDILKSVSIYGTERIGSTLRAKIKYNNNTDKPKVSYQWLRCKDKDGEYKEISGADKEEYKLKSNDKGYYLKVKVTVSGEVSENKESNRSEVIKEKLKDNSSSSNSGSSSSNDYNSGIVVDTDKTNDEQMYLNTSYSSKVDKEIFDLTKEYEYEKLILEGSNYVWNFNASDLKNVSQMDDSFDSEIQTKAQRDSEVVINFKHHGVLPGKATVQVNVGDELNGNNRYLYYYNEETNSLELISSNISVKKGKATFTITHCSKYILSANPNSNSNISSSDYNTTIDKSTQNNYVNNVVNSDKTSNESNFNNVDSSSLKWRESMDGKWYLCSNSFIMTGWQKVDNNWYYFNEFGVMQKDWVNSNGKWYYLDNNGCMATGWIKSNNNWYYINSNGEISTGWKEFNKVWYYFNTNGEMQTGWQYIDYRWYYLYPDGSMAYNVEIDGRVLNQNGAAR
>NZ_CP010520.1|WP_012449881.1|3145578_3147252_-|choline-binding-protein-A
MNKRLKRIIAIALTISAFSTIQPTKYINLFTTEAYAASSHISNLILNKTDTSNELKLYRDDEYDVSTEFRTSRNQYYAKTSLRSVNISCDTDSKYETYIFADSNKRSTAFEPDEEVELGKGTTTLYVRTYKEGRFDKNNVKNDVVDEYEIHIERTSSGSSNNSSLYLSSISLDYGKISFSKTKTSYDVDVNSSVDELEIKAKPSDEDYTVRIDGTKVKDSNGYEETVDLKKGKNVIEIAVTDEDDNEKIYTLNVYRGGRDSSSSDSSKEDNKQDPVYLDDLKLNNGDIKLDFNKKVTSYDVKVASTMDSVTIEAEPDDDEYEVTVNGKSVNSKNQRTVDLTLNKKNEIKVKVTNEDDEYRTYTLNITRGTVSSSNDNNNNNNSGTVTPGGTVTPGGGNNNNNSSNNNASAAKNKWVKTSNGNWQYYDENGLVLKNKWFKDTSKNKWYYLDANGDMKTNWLQNNGKWYYLNYDGSMMTGWTKINGFWYYLNTDGTMLVGWYKIGDNWYYSNADGAMRTGWLQEGKTKYYLNENGTMQKGQKTINGVNYNFDASGKLVE
>NZ_CP010520.1|WP_012451855.1|3143083_3145318_-|hypothetical-protein
MKINLKRIISQILIFAVMITGIQLDNIKAASAVELNLGFVVEAGGANLDINKSSSNAYYTDEIDMSVSTINIKSSDTSYYKLEGVTSSSSGVKIASSTTNGVTSYKIAVTKYNDFNATIKVKDLGTQEVKSYNVTFKFKEENADTFKFNKIMIVASGSGGSMTLDLDYNSDGDDYYISGLGDDVDTAKVSIVDENGKAITSGVKITMDGKTGTFKLLGGENEILISRTVNGRTKTFKLVIAKKGSAKLKSLTGITLSPRFDPETTDYTATVPTATDKVILKPTAADNSSTIRINGVLVTSGANSQPISLKEGKNDITIRVTTKDGEVGVYNLEVTRTEAPRSSYLKSLKINSASLSPSFNKQTFDYTATVENKVTAVTVTPTAEYATSTIKVNGKTVVSGGTTGYISLDEGSNEIEIKVTDAKGDTSTYDIVITRRYGKDNVKLSNLKSTEGTLSPKFDPETYLYTVKVDRAIGRTKLVFTAQNDKAVVKINGKEYASAQESDYIDLKIGANLINIEVVAEDKKTTTLYRVSVIRDKIQAINEWVLSGDDWTFYDALGYQVKNKWVKYDNQWYFVNINGYMEKNGWLNESGEWYYLNGDGTMKTGWFKDNGYWYYLQGDGKMKNSGWGYYDKEWYMFGPNGMLETGWKQHKGNWYFLLDNGTMRRGWQYYDLNWYYLNDDGTMKKGWLYDGKNYYYLNNSGVMKTGWQRINGKDYYFDSAGKMKTGFIFLDGKWYNLGQDGSLS
>NZ_CP010520.1|WP_012450883.1|3140685_3142500_-|N-acetylmuramoyl-L-alanine-amidase-family-protein
MIKRMNKLTALLVAATAVASIVPTGVSAADYKRIESKDGTIYNAVAFKDGKFFVDGNVKDGDTDAAYYLNDGKYSELDNIDTGVDVDGIYSDKYLSVDGGDYYIDLETGKVIDEDLVENNLDDLAVSLRKQIKDKVDDRYTTEHDTLKSVKDFTLLEGAKFANAWYGVKYDGNNVYTDIKGNYIDADYNLGKIKVEVTTGSSTKSVTLNNTEDTEKSITDGQKVSAKIADANVIGQDDKNIYRTATIEISAGTDTVAKINNVDVTAKDGKVEFKVIQKISKAQASDDIDGAKYAKTVANYAITNEKGVDATAELADMSFNIVDGKLVAYKTTESNGKTNVTVKTVKFSTERGYTYTEIENADDQDATAFDIDVDGNMWALDGGFVYKFDNADEWTKVYKVDGSMDQMSVYNKDNMVVWNENDEVYSVIGSKDESGETEDSQGWVQAEDGSWTFVKEDGTKATGWLNDNGTWFYLNSNGAMMTGWQNVNGTWYYLNPVSDGTRGAMKTGWINDNGTWYYTNASGAMQTGWQNVNGTWYFMQGSGAMQTGWLNDNGTWYYLQASGAMKTGWLNDNGTWYFLNASGKMLSNTVVDGYKLGANGAWIR
>NZ_CP010520.1|WP_012450441.1|3138084_3140589_-|LuxR-family-transcriptional-regulator
MIINPESLKNINSEYILNRKRIVKKVDSCLSCSNIVYFFAPIGSGKTIAMNYYVQKIKIDVLWFEMERKDNNNINLFNSLFKILNKFNDNKKRIVVLDSFDLISDSQRLEEFITLINKFSQNFKYIFLSRKKIPACFSLFIAKSMIQVVNSKDLCFNKDEINEFYSKNGIMLSQNKINKLIETTRGWPAILSIFLMCLKLQLTSNFESLFVHNEYVNDFIYKNIWKKFNPEIQRFLIILSLCDEIEINQYKEIIGEEDLEDFLEEVMNLHNNNVYVLNPIMRNFLIDRQSELADEEKVDVYKKVGIWYEKSNLNLEAAKYYGKANDYKNEIRNLEKFCSKKIEFKKIEIVEDYIRNLPQDILKNNSTLCATMAFICIIYYKLDEAIKWYENLLNIRDELNEKVKSISKNEDGKIYTTKEFLKYSRILLETEKNIDFIYFHMPHFNNKDMVKKFLEMKIKKPKYNNKFIENISLTFNFPSIINGIIDISSICVNYNEKFKEKKNLISDIYGDYGISLFNLACAEIDYEKENINKCLIKLTSEIIDYKRKAHIDMLFVAYIIFSKSMIVNGYINEAKIHLTTLKEFIKEKEADYLMKNFEAVYARINLLNGKLKEANDWILLYPTETEPRFNLLDMYKYFTKARIYIANGDYIKANTFLQIIYKLNYEYNNTYRIAECCILQSIALFNSKDEQLAFAKMEEALILMQNFDYTRIFADEGEACYKVLNNYIKSKDKDKRLDEKYIKKILLRTREFGAIYPKYLKIFDEFPEIYLTKSEIKILYLINKGMSNIEISEYLNIKKDTVKFHTKNIYSKLNVKNRIQAIKVAKEFGIIKEI
>NZ_CP010520.1|WP_012450702.1|3137438_3137756_-|hypothetical-protein
MDLDYSGWRNLDGKWYFFKDGSMKKGWVQDGYAWYYLNDDGEMQKGWIKDGESEYFTSPRGIMQTGWIDDCGILYYANKNGVIQKGKTTIEGKEYNFSRDGKLNS
>NZ_CP010520.1|WP_012450307.1|3135146_3136859_-|methyl-accepting-chemotaxis-protein
MDFYKNLKVRTKLMGSFCFMAIIVILLGIIVNNSIVKLNNAEKQMYKVNLQAMDKILSIKSNLETINGDILIIMHDKDVNMIEKSKKEIQNKVEENNKHIEEYESLNISDKEKQAWNEFKSDLDKYRTERNILVQNIYEEKYEEAELKYLDISPIRDNMLKSLNTLVKTNHNIAEASNKNNKDTFTKARRNIRLIVIASIFVAIALGLTSSISISKLLDKMKNFSERLASYDFSEPLILGTNNEFGQTADSLNKMQENVRELVKNIMDDSQDISSASEELSATVEELSANAMHINEAVNEIANGMYETSATSQEVTAAVEEVDLSINQLSSKAIQGSNNASEFKEKALVVQNNSKIAIENTEKLYIEKEKRMMKAIEDGRVVDNIRGMADTIANIASQTNLLALNAAIEAARAGEAGKGFAVVADEVRTLAEQSSLAVIGIQDTIVEVNKAFKISINTGTDILKFINDDIQKQFNAYGEAGHQYYNDSDFVSKMSEEISSMSQNVASTIGGVSKAIQNMDTIAQNSNERVDLIKESVNENTRAINEIALAAQGQAELAQKLTEMVQKFKI
>NZ_CP010520.1|WP_012450059.1|3133207_3134812_-|N-acetylmuramoyl-L-alanine-amidase-family-protein
MIKRIKKIMALVLVATSVVAIAPREMFKGNVTAYAATTKEGEWTEANEAQVQAGLKKYLKDNVCNSADEIKLTFMKYVKVDLSKETIEKIVTPIVTKEVTAQITEKVTAGAIAEAKKKQPELAALPDEKIAQMLKPQIDAKVKELVSQILPGKIQETTAQLQSATQQIPVYQYVGVKSDGTVVGMGVIAGGPIAGMLLPQKAIYVDTTKLGTVGNAVLPELIGKLEEAIKNLGGNISGIIGNISGTITGALDDVADSVDKISNSITDLFDDLDDSTDDFFDKINKDEGWDKHDGYVYYYDEDGIKYRGVHEIKGKNYYFNRVDGAMETGWQIVYGKRCYFSPKKGYQLYSQWIKDGDKIYCLDEKGEVRKSQWAQDGANSCYLKADGTVAKGWYSVNRDERYYFNETTGYIETSKWIYDDQEWYYLKDSGVAATDWECINGKWYCFKSTGKMYSGWFRNEGNWYYSDSTGAMQTGWVYHKNKWFYLDDSGKMKKNEWISVNGKWYYFNLNGEMITSSRYIDGIKYHFNSDGSLQ
>NZ_CP010520.1|WP_012451415.1|3132046_3132922_-|surface-protein-PspC
MNKKLKRIIAITLIIGAVSSVLPANYKVFNNEKVYASTKDDYLLKKLSVFEAKSGDEVDLLDNEWKKTNFNKKSKENYCVKVDSNIDSIRIDTSTDAEDYAIYKDDGKKNYKGKDILLYDGITKIYIKTYDSKSDADDDKNVKKEYKLTVKKSLDSNEGISSSDDNDIKNQNNSLSKFDNKVLNNAKRNQWVIVNGLWKYNNYLGDSLKDEWYHDTFNDKWYFLDSYGNMVTGWLNKGEQWYYFDSNGEMVTGWRSINGQWYYFNLLGKMMIERVLDNGKWYYFLPSGEMI
>NZ_CP010520.1|WP_012451156.1|3130539_3131886_-|hypothetical-protein
MNKRLKHIIAATLVVSAFTTITPAKYINLGAINAYASSSSISKDEFDDLVVCKGSSSKELQLYSSSSCKDSDEIDFKFGTKTYYVKISGSTNSVTIDAEVDSDYEAHVFKGNKDEPYDLGEEIKVGSGTTTLYVRIYEDGEFDEDDVEEDVVRTYKICVKNGSSSDDEDDSDSDKVYLKDLTLSDGVINFSKQKTSYDINVNESVNSIKIKAVPKNEDDYTVEIDGDKVDDGDKYKKEVDLKKGKNTIKINIEDDDDNKRTYILNITRGGTSTSGNQSINNNTNNKQDQNTVKPSTPADINKKFDQWVNANGKWQYNDSNGNIIKSKWHSDKSSGKWYYLDENGYMKTGWLKDGELWYYLDDNGAMKTGWLLLGSDWYYLNSNGSMHTGWLQSGSNWYFINRNTGVMKSNGWIVDNGKYYYFSSSGMMLSNVTINGYILGQDGAWIGR
>NZ_CP010520.1|WP_012451553.1|3152532_3154014_+|DUF2334-domain-containing-protein
MNKFFTYILLSLSLISLTGCNDINNSKSQIPENTNNTIENKIMDEDLTSDNLSKNNNLTLIDYSNFKDLGINKDNVTLKINGHDLDFNLPIYLDKNRYYFSLNEIIHNLNGTFTKDEDCLYLNIHDEIYSINLLDNTIHCPNKEFKLKKDLLNSENIYYICFFDLSNMLDLYTRWDKDNKIINCKINSNQYINDTSSKVNNDNYKNNSLNNELEDKNNSTSASSKNTQIGLIRFEDVCVTSQGYDKNYFENLRIIGEYMNEQNIPYHIAWIPRYKNPNFKIDNDPLTKNNFEIAEMVYTLDYLKNNNGIIGLHGYTHQFGNYESAAGFEFGKFEPSTDVFKEKIEKAIETASYLDIPIDFFEVPHYEITPEQNKIAEKYFKILYYPFNDYGVDKADLKMPQLSPYNNSSLYISTPLDYIAEGKENICLDRIKNSDISNMGSVFFHPSLENAFISLNEDSDGYPSFNYADNSILKRLVTILKEKGFKITKVTEL
>NZ_CP010520.1|WP_012450989.1|3154122_3156162_-|M13-family-metallopeptidase
MAKFKKSRLIACALVFSLFMSQATYVKAAEVTNTVNLGNKVVADDVRLQDDFYSVTNKEWLNTAKIDAGEVSNSAFNEAEKALTEQKKEIMKELLANEKNYSKDSDEKKMINLYKNVLNSEARNKQGIEPIKGMLDKIKNIKTLDDIRELNKYDIGNPLINIGCSVDLKDATRYAAYVGSTSLSLGNSDEYVKPTENTARVKGLSENYYKKILTLVGYTEEEAKMKVDNFYKLEYMIAPSIIGKEESTKNPNAIDDEYNVYTLDKLNDVSPNLKIKDLMKDLKIDKANKIILTEPNWLKAMNDIYTEENVPLIKDYIEIRNIAGAAGCLGDDFEKAAQEFSNAYLGSSGETPKDEEAINIVNSALAMPFGKIYVEKYFSKKTKNDVKDMTDEIIKTYEKRIENLDWMSDSTKKSAKEKLNKISVQIGYPEKWEDYSSLKIRSYEEGGSLFENLMNLSKFAEDKQLSVLNERVDKSQFACPPQMVNAFYNPTANSITVPAGILQQQFYDVNASKEHNLGAIGAVIGHEISHAFDNTGAKFDGDGNLNSWWSTEDSKKFEEKTNKVRSFYNNVKLDSGKNVNGDLTVGENIADLGGIACALDILNNMPKADYKVFFESNANVWREISTKEYGELKLQNDVHSPNKVRTNIVLSQFDEFYKTYGIKENDKMYVNPQDRLKIW
>NZ_CP010520.1|WP_012450432.1|3156613_3157108_-|hypothetical-protein
MYNVEHFDNDLYFLCSMIEYVGRETHNKRIDIINKIGFHNLKHEYICACVNHCLPVERVCAEWIENYKIEQGTFDNLATVDGIETPDFWSIGDVYMNLILNTLDYEYKAKDSETNSDHDSLIKHLMEVYNSSLAKVIDDYNNIVFTRSPMYLWDCYIKNEILDF
>NZ_CP010520.1|WP_012449860.1|3157100_3157616_-|DUF3990-domain-containing-protein
MTKFHSTNNSINNTVNNLESIGVYHGSDCIVEKPQIFTKGYYKDFGFGFYVTKIKKQAERWTLKKEPKVVNIYEIDKNYKENLNVKIFSEMTEEWLDFITACRSGKSHDYDIVEGPMADDTIFQFVNMFISKRITREAFWALCKFKYPTHQILFATEKSLNYLKYKGCYYV
>NZ_CP010520.1|WP_012450830.1|3157941_3158676_-|phage-protein
MERKIVKLRVDMYNDTKFKIIDTMEHRDLIHYIWTRLLTLAGKVNLEGKLYLSRSIPYTIETLALEFNRSVKKVELALKVFMDLEMIELGENNVYKVRNFAKHQNIKPKKKEDSNDKKDSNVNIESINVRDNINKKDNIEIQNKDILDKINLNKASATENFLNNKSDVKNKIELKDKSDLDAEFVFSKANDNKKRSKPKIKNKKVSKKNDNEIISSWDDEADDIKICEFTDEPPKGKLIATFKV
>NZ_CP010520.1|WP_003373918.1|3158917_3159766_-|glycosyltransferase
MKISVICPLYNAENYIYNLNNNILTQELDSEQELEILYVLTRSIDKSEDILKKLNCNYCVVEPKKFSHSLTREIMANKVSGDIIVFISQDVKMKNKLWLKNLVTPIISGECEASFSRQICENNSIEKYTREKNYPEESRVVSKKDIEKYGLLTFFYSDASSAVNAKIYRELNAYDGKDMPTNEDMYFAHKLIHAGYRIKYCADSEVYHSHDFTFKQLYNRYYDTGVFFKENSYLMKYKGNESGFTLAKYVFKRALKERNIKVIFSLLPNFGVRYIAMKIGQK
>NZ_CP010520.1|WP_012450659.1|3159885_3160719_+|hypothetical-protein
MEIFFIKYSGIFSLLYLLYTLILTFIISKSLDFINKCHNNNNIYSLNEDDCFVLNNKYNTEKLFYYITYKLYAKKILSKDTLRNKFYINDTSICSLSPIEENVYTVYLNKFAPKNFKSNMINEDIFRNYYNTIYSTLELHGFIKKDTLIRKNKLVFFIGLLLLITPGIYYVFNYYINKTLILKIILVNIIALFIYIILLKNRAYNKLTYKGLNSKVFYKNTCSSIESSIENETYVETMNEFLLDNSWMYFLGVNHIFNDDNDDDSCDDDFDGDDFGD
>NZ_CP010520.1|WP_003373150.1|3160806_3161037_-|acyl-carrier-protein
MEKLISLLEDIRDDVDFKECTTLIEDGILDSFDIIQIVNAIDEEFDVEIPATEIIPENFNSADSLLKMIRRLEEEE
>NZ_CP010520.1|WP_012451436.1|3161083_3162598_-|amino-acid-adenylation-domain-containing-protein
MEKNILIYLEKSKEEFPDKIAFSDNKRKLTYLELVNSSKSIGSFLIEKIGVRKPVVVYMEKGAHNIAAFMGVAYSGGFYVPLDSQMPMERINIILKTLKPEAVIYDGTTEKHLKSMESDCIKISYDEICNTPHNDEKLDSVRKSMIDTDPLYVLFTSGSTGVPKGVIVCHRSVIDYADWVTKTFKLNENTVFGNQTPFYFSMSVLDIFSTIYSGATLHIIPKMLFSFPVKLLEYLNENKVNTIYWVPSALSIVANLGALDAVELPNLKKVLFAGETMPTKQLNIWRKHIPNALYANLFGPTEITDIGVHYIVDREFKDEEPIPIGVPCDNVDAIVVDEDGNLIKESGTVGELLIRGSFLACGYYKNPEKTNEVFIQNPLNNSYPETVYCTGDLVYWNENRELVYASRKDFQIKHMGNRIELGEIENAMNSLDNVDMCCCLYNNQNDQIVAIYTGNLEKKEMAKVLMKKLPRYMLPNVYNQRESMPLNLNGKIDRIQLKKEYLEK
>NZ_CP010520.1|WP_012451496.1|3162618_3163977_-|hypothetical-protein
MHNSKLAWFKTIIFIILLIFINNILIYIISPVNNISRNTILDMYSEKNNIDMVFAGSSYSRRIDPYIMDKELDCNTFNYGFNGQIYIGTYYCLKELFKYHKPKTVVVSTDLNSYIDKEENPKSYMAIISSLKSITNKLEFYFNSANDGSYLNRLLIWPEYHLDSLKDIPSNIKKKNEKSYIDYPDENQSQIYKESYENKKSGYMGKGFLKIDVSNPKNVLKDNKLGKMVIKNTNLNDIKEKNIKYFKKIVDLCKENSAEVIFLQAPIPTHSIFSEKNYFKFDEEISRISKENGVDYYNFNLIKPELFKSKTEYFQDKFHLNATGSEVFSKSFAEFLKLRSSGEDMSKYFYTSEEYFDTINYINNTWFTWKMDKDKIDIKADSFYGNNIKPEYQFILIDSKTGKKEVIRDYDTNPNFTLKKPKLSTYKIRVNAREVGNNVEFSRYYEEGFGKK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP010520_3	3.6\|1745115\|36\|NZ_CP010520\|CRISPRCasFinder,CRT,PILER-CR	1745115-1745150	36	NZ_CP010520.1	961099-961134	0	1.0

1. spacer 3.6|1745115|36|NZ_CP010520|CRISPRCasFinder,CRT,PILER-CR matches to position: 961099-961134, mismatch: 0, identity: 1.0

tcaaacacttggagtttttacagatactataataat	CRISPR spacer
tcaaacacttggagtttttacagatactataataat	Protospacer
************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP010520_2	2.1\|1658029\|34\|NZ_CP010520\|PILER-CR,CRISPRCasFinder,CRT	1658029-1658062	34	NZ_CP047113	Proteus mirabilis strain SCBX1.1 plasmid plas1.1.1, complete sequence	5294-5327	9	0.735
NZ_CP010520_2	2.1\|1658029\|34\|NZ_CP010520\|PILER-CR,CRISPRCasFinder,CRT	1658029-1658062	34	NZ_CP053900	Proteus mirabilis strain YPM35 plasmid pJPM35-2, complete sequence	24237-24270	9	0.735

1. spacer 2.1|1658029|34|NZ_CP010520|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP047113 (Proteus mirabilis strain SCBX1.1 plasmid plas1.1.1, complete sequence) position: , mismatch: 9, identity: 0.735

tcatcacatacgttaaatatatttttaactacct	CRISPR spacer
actttgcatacggtaaaaatatttttaactatga	Protospacer
 * *..****** **** *************.

2. spacer 2.1|1658029|34|NZ_CP010520|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP053900 (Proteus mirabilis strain YPM35 plasmid pJPM35-2, complete sequence) position: , mismatch: 9, identity: 0.735

tcatcacatacgttaaatatatttttaactacct	CRISPR spacer
actttgcatacggtaaaaatatttttaactatga	Protospacer
 * *..****** **** *************.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

438757 : 491916

Clostridium_phage(23.08%)

protease,coat,tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_040968359.1\|438757_439777_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	1.6e-64	40.4
WP_012449851.1\|439779_440784_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_012451030.1\|440947_442135_+\|protease	trypsin-like serine protease	A0A1B1IT49	uncultured_Mediterranean_phage	1.2e-15	26.8
WP_003370889.1\|442298_442718_+	carboxypeptidase regulatory-like domain-containing protein	NA	NA	NA	NA
WP_012449636.1\|443042_444125_+	ethanolamine utilization protein EutH	NA	NA	NA	NA
WP_012451456.1\|444150_445275_+	extracellular solute-binding protein	NA	NA	NA	NA
WP_012450092.1\|445277_446399_-	glycosyltransferase family 4 protein	B6EFC4	Stygiolobus_rod-shaped_virus	1.4e-05	32.3
WP_012449498.1\|446545_447562_+\|coat	CotS family spore coat protein	NA	NA	NA	NA
WP_012449925.1\|447536_448307_+\|coat	spore coat protein	NA	NA	NA	NA
WP_012451906.1\|448395_449448_+\|coat	CotS family spore coat protein	NA	NA	NA	NA
WP_012450868.1\|449641_450784_-	glycosyltransferase family 4 protein	A0A1X9SJR9	Sulfolobus_islandicus_rod-shaped_virus	5.0e-06	31.5
WP_012450479.1\|450893_451895_+\|coat	CotS family spore coat protein	NA	NA	NA	NA
WP_012451365.1\|452219_453083_+	sporulation peptidase YabG	NA	NA	NA	NA
WP_003369318.1\|453270_453513_+	protein veg	NA	NA	NA	NA
WP_012451197.1\|453926_455489_+	DUF3794 domain-containing protein	NA	NA	NA	NA
WP_012449460.1\|455648_456494_+	cyanophycinase	NA	NA	NA	NA
WP_012451943.1\|456465_459084_+	cyanophycin synthetase	NA	NA	NA	NA
WP_012451223.1\|459263_460106_+	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	NA	NA	NA	NA
WP_012450528.1\|460167_460794_+	stage II sporulation protein R	NA	NA	NA	NA
WP_012451190.1\|460831_461824_+	DUF814 domain-containing protein	NA	NA	NA	NA
WP_012450981.1\|461893_462316_+	DUF1934 domain-containing protein	NA	NA	NA	NA
WP_003370410.1\|462550_462850_+	hypothetical protein	NA	NA	NA	NA
WP_012449540.1\|463033_464635_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	1.4e-150	51.4
WP_079990996.1\|465037_466654_+	transcription termination factor Rho	NA	NA	NA	NA
WP_012451175.1\|466702_467809_-	galactosyldiacylglycerol synthase	NA	NA	NA	NA
WP_003374052.1\|467950_468160_-	50S ribosomal protein L31	NA	NA	NA	NA
WP_012449758.1\|468337_468925_+	thymidine kinase	A0A249XXF6	Clostridium_phage	1.5e-51	51.6
WP_012451530.1\|470987_472070_+	peptide chain release factor 1	NA	NA	NA	NA
WP_012449866.1\|472152_472740_+	hypothetical protein	NA	NA	NA	NA
WP_012450655.1\|472758_473808_+	threonylcarbamoyl-AMP synthase	S4VW33	Pandoravirus	3.0e-45	37.0
WP_012451234.1\|473930_474380_+	ribose 5-phosphate isomerase B	NA	NA	NA	NA
WP_003372223.1\|474425_475055_+	uracil phosphoribosyltransferase	NA	NA	NA	NA
WP_012451388.1\|475164_475659_+	cytidine deaminase	A7KUY9	Bacillus_phage	5.5e-10	31.8
WP_012449710.1\|475787_476936_+	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	A0A1V0SAG5	Catovirus	3.1e-27	28.0
WP_003374763.1\|477065_478247_+	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_012450323.1\|479126_479492_+	hypothetical protein	NA	NA	NA	NA
WP_012450700.1\|479493_480174_+	F0F1 ATP synthase subunit A	NA	NA	NA	NA
WP_003369994.1\|480205_480421_+	ATP synthase F0 subunit C	NA	NA	NA	NA
WP_012424573.1\|480471_480951_+	F0F1 ATP synthase subunit B	NA	NA	NA	NA
WP_003373046.1\|480953_481493_+	F0F1 ATP synthase subunit delta	NA	NA	NA	NA
WP_003370679.1\|481503_483018_+	F0F1 ATP synthase subunit alpha	NA	NA	NA	NA
WP_003369206.1\|483058_483910_+	F0F1 ATP synthase subunit gamma	NA	NA	NA	NA
WP_003373604.1\|483925_485317_+	F0F1 ATP synthase subunit beta	NA	NA	NA	NA
WP_003371522.1\|485330_485735_+	ATP synthase F1 subunit epsilon	NA	NA	NA	NA
WP_012450007.1\|485894_486533_+	hypothetical protein	NA	NA	NA	NA
WP_012450874.1\|486590_487853_+	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_012451086.1\|487970_489008_+	stage II sporulation protein D	Q2XU88	Pseudomonas_phage	5.9e-38	38.4
WP_012450551.1\|489166_489892_+	M23 family metallopeptidase	V5R8R0	Arthrobacter_phage	5.5e-06	30.9
WP_003373770.1\|489982_490237_+	sporulation transcriptional regulator SpoIIID	M9Q261	Clostridium_phage	4.8e-18	60.0
WP_003374639.1\|490316_491351_+	rod shape-determining protein	NA	NA	NA	NA
WP_012450000.1\|491394_491916_-\|protease	spore protease YyaC	A0A0A8WIQ6	Clostridium_phage	4.8e-28	37.9

DBSCAN-SWA_2

906887 : 929056

Clostridium_phage(75.0%)

plate,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003370603.1\|906887_908012_+	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	4.2e-37	37.6
WP_012450333.1\|908104_908791_+	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_012450186.1\|908908_909700_+	Nif3-like dinuclear metal center hexameric protein	NA	NA	NA	NA
WP_012450896.1\|909756_909993_+	hypothetical protein	NA	NA	NA	NA
WP_012449952.1\|910478_910940_-	membrane protein	A0A0A7RTX7	Clostridium_phage	1.6e-35	50.7
WP_012449566.1\|910957_911323_-	helix-turn-helix transcriptional regulator	A0A2I7SCV6	Paenibacillus_phage	1.8e-05	49.2
WP_012451074.1\|911577_912087_+	helix-turn-helix domain-containing protein	I2E8Y5	Clostridium_phage	5.3e-32	45.3
WP_012450549.1\|912847_913264_+	hypothetical protein	A0A0A7RTL8	Clostridium_phage	7.7e-05	32.2
WP_012450957.1\|913409_914720_+	hypothetical protein	A0A0A7S087	Clostridium_phage	4.9e-130	54.8
WP_012450094.1\|914738_915206_+\|tail	phage tail tube protein	A0A0A7RVP1	Clostridium_phage	5.2e-58	72.4
WP_012449452.1\|915505_915919_+	hypothetical protein	A0A0A7RTN3	Clostridium_phage	4.4e-45	62.2
WP_012449442.1\|916114_918064_+	hypothetical protein	A0A0A7S0K9	Clostridium_phage	7.7e-63	33.0
WP_012451299.1\|918063_918726_+	LysM peptidoglycan-binding domain-containing protein	A0A0A7RW06	Clostridium_phage	4.9e-70	57.7
WP_012451227.1\|918737_919709_+	hypothetical protein	A0A0A7RTZ4	Clostridium_phage	3.4e-104	56.8
WP_012450668.1\|919712_920042_+	DUF2577 domain-containing protein	A0A0A7RTJ2	Clostridium_phage	6.2e-26	53.8
WP_012451369.1\|920034_920442_+	DUF2634 domain-containing protein	A0A0A7RTH1	Clostridium_phage	3.0e-38	62.5
WP_012450854.1\|920444_921503_+\|plate	baseplate J/gp47 family protein	A0A0A7S0L4	Clostridium_phage	1.1e-90	51.7
WP_040992110.1\|921503_923585_+	hypothetical protein	A0A0A7S1G0	Clostridium_phage	8.4e-76	35.5
WP_012450245.1\|923586_924201_+	YmfQ family protein	A0A0A7RTU9	Clostridium_phage	1.1e-60	57.1
WP_012451725.1\|925032_925368_+	hypothetical protein	NA	NA	NA	NA
WP_012451007.1\|925360_925495_+	XkdX family protein	A0A0A7S0E7	Clostridium_phage	6.5e-06	54.5
WP_012450325.1\|925608_925809_+	UviB-like protein	A0A2H4JAI7	uncultured_Caudovirales_phage	6.5e-18	67.7
WP_012451124.1\|925947_926742_+	glycoside hydrolase	A0A1U9WQS3	Geobacillus_phage	7.7e-38	42.7
WP_012450478.1\|926889_927054_+	hypothetical protein	NA	NA	NA	NA
WP_012451324.1\|927076_927643_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_012450785.1\|928009_929056_+	hypothetical protein	A0A1P8CWN9	Bacillus_phage	9.9e-09	44.2

DBSCAN-SWA_3

1076723 : 1090477

Cyanophage(22.22%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012450048.1\|1076723_1077404_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.1e-31	39.1
WP_003369129.1\|1077554_1077710_+	cytochrome c551	NA	NA	NA	NA
WP_012451322.1\|1077814_1079071_+	chloride channel protein	NA	NA	NA	NA
WP_003369960.1\|1079174_1080065_+	oxidoreductase	A0A1V0SDE7	Indivirus	3.8e-09	26.8
WP_012451813.1\|1080324_1084071_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	7.4e-30	30.9
WP_003371243.1\|1084479_1084959_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.3e-27	45.5
WP_003369697.1\|1084958_1085666_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SLB8	Cyanophage	3.3e-48	45.2
WP_003373905.1\|1085781_1087209_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.3e-54	32.3
WP_012450386.1\|1087218_1088220_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SR00	Cyanophage	1.8e-68	46.6
WP_017826400.1\|1088207_1088822_+	phosphoribosylglycinamide formyltransferase	R9S626	Prochlorococcus_phage	1.6e-22	36.1
WP_012450774.1\|1088971_1090477_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	E3SNU8	Prochlorococcus_phage	4.7e-36	46.0

DBSCAN-SWA_4

1831661 : 1861190

Bacteriophage(28.57%)

plate,capsid,tail,protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012450019.1\|1831661_1832591_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_003374362.1\|1832640_1832874_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_012451165.1\|1832949_1834239_+	hypothetical protein	NA	NA	NA	NA
WP_003370058.1\|1834410_1835016_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	1.7e-13	56.2
WP_012449632.1\|1835191_1835623_+	hypothetical protein	NA	NA	NA	NA
WP_012451613.1\|1835692_1836184_+	hypothetical protein	NA	NA	NA	NA
WP_012450810.1\|1836366_1836897_+	YtxH domain-containing protein	NA	NA	NA	NA
WP_012449529.1\|1837010_1838000_-	tyrosine recombinase XerC	A0A2R2ZHE2	Clostridioides_phage	2.8e-21	28.9
WP_012450588.1\|1838670_1839150_+\|tRNA	Cys-tRNA(Pro) deacylase	NA	NA	NA	NA
WP_012451298.1\|1839472_1840843_-\|tRNA	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	NA	NA	NA	NA
WP_040992117.1\|1841079_1841292_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_144311748.1\|1842644_1842821_-	hypothetical protein	NA	NA	NA	NA
WP_040968293.1\|1842830_1843031_-	UviB-like protein	A0A2H4JAI7	uncultured_Caudovirales_phage	2.0e-19	70.8
WP_012449645.1\|1843104_1844109_-	hypothetical protein	A0A1L2BYA9	Clostridium_phage	9.2e-12	38.5
WP_012450733.1\|1846151_1846349_-	hypothetical protein	NA	NA	NA	NA
WP_040968296.1\|1846361_1846700_-	hypothetical protein	NA	NA	NA	NA
WP_040968297.1\|1846715_1848125_-\|tail	phage tail protein	A0A0A7RTP0	Clostridium_phage	8.3e-59	67.3
WP_012449486.1\|1848124_1848787_-\|tail	phage tail protein I	A0A0C5AJ63	Bacteriophage	1.0e-22	41.1
WP_144311752.1\|1848786_1849893_-	hypothetical protein	A0A059WFM2	Vibrio_phage	1.2e-57	37.0
WP_012450959.1\|1849930_1850251_-	hypothetical protein	NA	NA	NA	NA
WP_012449967.1\|1850253_1850796_-	hypothetical protein	NA	NA	NA	NA
WP_012451795.1\|1850800_1851001_-\|plate	phage baseplate assembly protein V	NA	NA	NA	NA
WP_144311749.1\|1851000_1851924_-	hypothetical protein	H7BVZ1	unidentified_phage	3.3e-32	29.1
WP_040968298.1\|1851924_1852155_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_012449743.1\|1852129_1854328_-	hypothetical protein	A0A218KCH0	Bacillus_phage	2.4e-41	34.3
WP_012451061.1\|1854493_1854817_-	hypothetical protein	NA	NA	NA	NA
WP_012451782.1\|1854886_1855408_-\|tail	phage major tail tube protein	A0A0C5AJ56	Bacteriophage	1.5e-21	37.2
WP_012451286.1\|1855407_1856844_-	hypothetical protein	A0A2K9V2R6	Faecalibacterium_phage	5.1e-80	35.6
WP_012450688.1\|1856856_1857381_-	hypothetical protein	NA	NA	NA	NA
WP_012449968.1\|1857390_1857963_-	hypothetical protein	A0A0C5AEN6	Bacteriophage	1.4e-09	26.8
WP_012451331.1\|1857962_1858274_-	hypothetical protein	NA	NA	NA	NA
WP_012450951.1\|1858263_1858491_-	hypothetical protein	NA	NA	NA	NA
WP_012450276.1\|1858521_1859568_-\|capsid	major capsid protein	A0A0C5ABI0	Bacteriophage	2.6e-86	47.1
WP_012449726.1\|1859583_1859931_-	hypothetical protein	NA	NA	NA	NA
WP_079990991.1\|1859930_1861190_-\|protease	Clp protease ClpP	A0A067ZG37	Vibrio_phage	5.7e-51	36.4

DBSCAN-SWA_5

1873386 : 1879926

Clostridium_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012449837.1\|1873386_1873599_-	hypothetical protein	A0A0A7RUN7	Clostridium_phage	6.2e-19	60.9
WP_012451283.1\|1873717_1873984_-	hypothetical protein	NA	NA	NA	NA
WP_012450636.1\|1874181_1874508_+	hypothetical protein	NA	NA	NA	NA
WP_040968299.1\|1874583_1874769_-	hypothetical protein	NA	NA	NA	NA
WP_012449973.1\|1875198_1876140_-	helix-turn-helix domain-containing protein	A0A1L2BY83	Clostridium_phage	1.1e-64	61.8
WP_012450314.1\|1876252_1877401_-	ParB N-terminal domain-containing protein	A0A1D6Z271	Staphylococcus_phage	3.6e-12	34.2
WP_012450952.1\|1877385_1878141_-	ParA family protein	A0A1X9IGI7	Lactococcus_phage	1.6e-21	29.0
WP_012451023.1\|1878353_1878527_-	hypothetical protein	NA	NA	NA	NA
WP_012451770.1\|1878555_1879032_-	hypothetical protein	A0A2K9V3J3	Faecalibacterium_phage	1.0e-21	40.8
WP_012451011.1\|1879153_1879345_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_012451504.1\|1879521_1879926_+	helix-turn-helix domain-containing protein	A8ATJ9	Listeria_phage	2.7e-10	44.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP010520

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection